Patent Publication Number: US-2010120045-A1

Title: Genetic variants useful for risk assessments of coronary artery disease and myocardial infarction

Description:
BACKGROUND OF THE INVENTION 
     Epidemiology and Etiology 
     Cardiovascular diseases continue to be the principal cause of death in developed countries (Bonow, R O et al.,  Circulation  106:1602-05 (2002)). The costs of these diseases are high both in terms of morbidity and mortality, as well as in terms of the financial burden on health care systems. The major complications of coronary artery disease, i.e. Myocardial Infarction (MI) and Acute Coronary Syndrome (ACS), are the leading causes of hospital admissions in industrialized countries. Of all deaths caused by cardiovascular diseases, more than half are attributed to heart attack (myocardial infarction (MI)). The cost of the disease is high both in terms of morbidity and mortality, as well as in terms of the financial burden on the health care systems. According to the NHLBI&#39;s ARIC study (Thom, T et al.,  Circulation  113:e85-151 (2006)), the annual rate of first heart attack (MI or coronary heart disease (CHD) death) per 1000 individuals for ages 65-74 are 19.2 and 6.8, in European American men and women, respectively. For the same age group, the rates are 21.6 and 8.6, in African American men and women respectively. In the older age groups these numbers are much higher with the lifetime risk after the age of 40 of developing heart attack being 49% for men and 32% for women. 
     Myocardial infarction generally occurs when there is an abrupt decrease in coronary blood flow following a thrombotic occlusion of a coronary artery previously damaged by atherosclerosis (i.e. in subjects with coronary artery disease). In most cases, infarction occurs when an atherosclerotic plaque fissures, ruptures or ulcerates and when conditions favor thrombogenesis. In rare cases, infarction may be due to coronary artery occlusion caused by coronary emboli, congenital abnormalities, coronary spasm, and a wide variety of systemic, particularly inflammatory diseases. Medical risk factors for MI include cigarette smoking, diabetes, hypertension and serum total cholesterol levels &gt;200 mg/dL, elevated serum LDL cholesterol, and low serum HDL cholesterol. Event rates in individuals without a prior history of cardiovascular disease are about 1%. In individuals who have had a first MI or ACS, the risk of a repeat MI within the next year is 10-14%, despite maximal medical management including angioplasty and stent placement. 
     Atherosclerosis can affect vascular beds in many large and medium arteries. Myocardial infarction and unstable angina (acute coronary syndrome (ACS)) stem from coronary artery atherosclerosis (coronary artery disease), while ischemic stroke most frequently is a consequence of carotid or cerebral artery atherosclerosis. Limb ischemia caused by peripheral arterial occlusive disease (PAOD) may occur as a consequence of iliac, femoral and popliteal artery atherosclerosis. The atherosclerotic diseases remain common despite the wide-spread use of medications that inhibit thrombosis (aspirin) or treat medical risk factors such as elevated cholesterol levels in blood (statins), diabetes, or hypertension (diuretics and antihypertensives). 
     Atherosclerotic disease is initiated by the accumulation of lipids within the artery wall, and in particular, the accumulation of low-density lipoprotein (LDL) cholesterol. The trapped LDL becomes oxidized and internalized by macrophages. This causes the formation of atherosclerotic lesions containing accumulations of cholesterol-engorged macrophages, referred to as “foam cells”. As disease progresses, smooth muscle cells proliferate and grow into the artery wall forming a “fibrous cap” of extracellular matrix enclosing a lipid-rich, necrotic core. Present in the arterial walls of most people throughout their lifetimes, fibrous atherosclerotic plaques are relatively stable. Such fibrous lesions cause extensive remodeling of the arterial wall, outwardly displacing the external, elastic membrane, without reduction in luminal diameter or serious impact on delivery of oxygen to the heart. Accordingly, patients can develop large, fibrous atherosclerotic lesions without luminal narrowing until late in the disease process. However, the coronary arterial lumen can become gradually narrowed over time and in some cases compromise blood flow to the heart, especially under high demand states such as exercise. This can result in reversible ischemia causing chest pain relieved by rest called stable angina. 
     In contrast to the relative stability of fibrous atherosclerotic lesions, the culprit lesions associated with myocardial infarction and unstable angina (each of which are part of the acute coronary syndrome) are characterized by a thin fibrous cap, a large lipid core, and infiltration of inflammatory cells such as T-lymphocytes and monocyte/macrophages. Non-invasive imaging techniques have shown that most MI&#39;s occur at sites with low- or intermediate-grade stenoses, indicating that coronary artery occlusion is due most frequently to rupture of culprit lesions with consequent formation of a thrombus or blood clot and not solely due to luminal narrowing by stenosis. Plaque rupture may be due to erosion or uneven thinning of the fibrous cap, usually at the margins of the lesion where macrophages enter, accumulate, and become activated by a local inflammatory process. Thinning of the fibrous cap may result from degradation of the extracellular matrix by proteases released from activated macrophages. These changes producing plaque instability and risk of MI may be augmented by production of tissue-factor procoagulant and other factors increasing the likelihood of thrombosis. 
     In acute coronary syndrome, the culprit lesion showing rupture or erosion with local thrombosis typically is treated by angioplasty or by balloon dilation and placement of a stent to maintain luminal patency. Patients experiencing ACS are at high risk for a second coronary event due to the multi-vessel nature of coronary artery disease with event rates approaching 10-14% within 12 months after the first incident. 
     The emerging view of MI is as an inflammatory disease of the arterial vessel wall on preexisting chronic atherosclerotic lesions, sometimes triggering rupture of culprit lesions and leading to local thrombosis and subsequent myocardial infarction. The process that triggers and sustains arterial wall inflammation leading to plaque instability is unknown, however, it results in the release into the circulation of tumor necrosis factor alpha and interleukin-6. These and other cytokines or biological mediators released from the damaged vessel wall stimulate an inflammatory response in the liver causing elevation in several non-specific general inflammatory markers including C-reactive protein. Although not specific to atherosclerosis, elevated C-reactive protein (CRP) and serum amyloid A appear to predict risk for MI, perhaps as surrogates for vessel wall inflammation. Many general inflammatory markers predict risk of coronary heart disease, although these markers are not specific to atherosclerosis. For example, Stein (Stein, S.,  Am J Cardiol,  87 (suppl):21A-26A (2001)) discusses the use of any one of the following serum inflammatory markers as surrogates for predicting risk of coronary heart disease including C-reactive protein (CRP), serum amyloid A, fibrinogen, interleukin-6, tissue necrosis factor-alpha, soluble vascular cell adhesion molecules (sVCAM), soluble intervascular adhesion molecules (sICAM), E-selectin, matrix metalloprotease type-1, matrix metalloprotease type-2, matrix metalloprotease type-3, and matrix metalloprotease type-9. Elevation in one more of these serum inflammatory markers is not specific to coronary heart disease but also occurs with age or in association with cerebrovascular disease, peripheral vascular disease, non-insulin dependent diabetes, osteoarthritis, bacterial infection, and sepsis. Elevated CRP or other serum inflammatory markers is also prognostic for increased risk of a second myocardial infarct in patients with a previous myocardial infarct (Retterstol, L. et al.,  Atheroscler.,  160: 433-440 (2002)). 
     Although classical risk factors such as smoking, hyperlipidemia, hypertension, and diabetes are associated with many cases of coronary heart disease (CHD) and MI, many patients do not have involvement of these risk factors. In fact, many patients who exhibit one or more of these risk factors do not develop MI. Family history has long been recognized as one of the major risk factors. Although some of the familial clustering of MI reflects the genetic contribution to the other conventional risk factors, a large number of studies have suggested that there are significant genetic susceptibility factors, beyond those of the known risk factors (Friedlander Y, et al.,  Br. Heart J.  1985; 53:382-7, Shea S. et al.,  J. Am. Coll. Cardiol.  1984; 4:793-801, and Hopkins P. N., et al.,  Am. J. Cardiol.  1988; 62:703-7). Major genetic susceptibility factors have only been identified for the rare Mendelian forms of hyperlipidemia such as a familial hypercholesterolemia. 
     Genetic Risk Factors 
     Genetic risk of disease is conferred by subtle differences in genes among individuals in a population. Genes differ between individuals most frequently due to single nucleotide polymorphisms (SNP), although other variations are also important. SNPs are located on average every 1000 base pairs in the human genome. Accordingly, a typical human gene containing 250,000 base pairs may contain 250 different SNPs. Only a minor number of SNPs are located in exons and alter the amino acid sequence of the protein encoded by the gene. Most SNPs have no effect on gene function, while others may alter transcription, splicing, translation, or stability of the mRNA encoded by the gene. Additional genetic polymorphisms in the human genome are caused by insertions, deletions, translocations, or inversions of either short or long stretches of DNA. Genetic polymorphisms conferring disease risk may therefore directly alter the amino acid sequence of proteins, may increase the amount of protein produced from the gene, or may decrease the amount of protein produced by the gene. 
     As genetic polymorphisms conferring risk of disease are uncovered, genetic testing for such risk factors is becoming important for clinical medicine. Examples are apolipoprotein E testing to identify genetic carriers of the ApoE4 polymorphism in dementia patients for the differential diagnosis of Alzheimer&#39;s disease, and of Factor V Leiden testing for predisposition to deep venous thrombosis. More importantly, in the treatment of cancer, diagnosis of genetic variants in tumor cells is used for the selection of the most appropriate treatment regime for the individual patient. In breast cancer, genetic variation in estrogen receptor expression or heregulin type 2 (Her2) receptor tyrosine kinase expression determine if anti-estrogenic drugs (tamoxifen) or anti-Her2 antibody (Herceptin) will be incorporated into the treatment plan. In chronic myeloid leukemia (CML) diagnosis of the Philadelphia chromosome genetic translocation fusing the genes encoding the Bcr and Abl receptor tyrosine kinases indicates that Gleevec (STI571), a specific inhibitor of the Bcr-Abl kinase should be used for treatment of the cancer. For CML patients with such a genetic alteration, inhibition of the Bcr-Abl kinase leads to rapid elimination of the tumor cells and remission from leukemia. 
     The familial clustering of CAD and MI has long been recognized and family history is considered one of the major risk factors for MI. Evidence for a genetic contribution to MI has been provided by both twin and family studies. These studies have estimated the heritability of MI to be 0.26 in males and 0.60 in females (Jorde, L. et al.  Medical Genetics  3 rd  ed. St. Louis: Mosby (2003)) and that the concordance rates for monzygotic vs. dizygotic twins is 0.39 vs. 0.26 for males and 0.44 vs. 0.14 for females. A longitudinal study of 21,004 Swedish twins showed that the relative hazard of death from CAD when one twin died of an early-onset CAD (defined as before age of 55 for males and 65 for females), compared to the hazard ratio when one&#39;s twin did not die of early-onset CAD, was 8.1 and 3.8 for male monozygotic and dizygotic twins, respectively (Marenberg, Me.,  N Engl J Med  330:1041-46 (1994)). The corresponding relative hazard for female twins was 15 for monozygotic twins and 2.6 for dizygotic twins. 
     Family studies have consistently demonstrated that having a first degree relative with premature CAD death increases the risk of developing CAD (Schildkraut, 3M et al  Am J Cardiol  64:555-59 (1989); Slack, 3 &amp; Evans, K A,  J Med Genet  3:239-57 (1966)), although the reported increase in risk has varied between studies. The mechanisms/processes by which the family history contributes to MI are currently not well defined. Some of the familial clustering of MI may reflect the familial aggregation to the other conventional risk factors. However, a large number of studies, including the Reykjavik Cohort Study, have suggested that there are significant genetic susceptibility factors, beyond those of the known risk factors (Friedlander, Y.,  Br Heart J  53:382-87 (1985); Shea, S.,  J Am Coll Cardiol  4:793-801 (1984); Andresdottir, M B,  Eur Heart J  23:1655-63 (2002)). The Reykjavik Cohort Study in Iceland examined the relationship between the history of MI in first-degree relatives and the risk of developing CHD (MI or coronary revascularization) in a large prospective study. Compared with subjects without a family history, the hazard ratio of CHD was 1.75 (95% CI: 1.59-1.92) for men and 1.83 (1.60-2.11) for women, with one or more first-degree relatives with MI, and after adjusting for the conventional risk factors, it was 1.66 (1.51-1.82) and 1.64 (1.43-1.89) for men and women, respectively (Andresdottir, M B,  Eur Heart J  23:1655-63 (2002)). 
     Case-control association studies have suggested the involvement of specific genetic susceptibility variants for MI. The majority of those studies have focused on variants in selected candidate genes (the candidate gene approach), genes that might be involved in the pathogenesis of the disease, or in the development of the intermediate phenotype (e.g. known risk factors). In most cases SNPs that change amino acids or are in promoter regions of genes, have been tested for association. Two studies have tested variants within multiple candidate genes for association with MI. In one, association of C1019T polymorphism in the connexin 37 gene to MI in men and 4G-668-5G polymorphism in the plasminogen-activator-inhibitor type 1 gene and the 5A-1171/6A polymorphism in the stromelysin-1 gene in women Was reported (Yamada, Y. et al  N Engl J Med  347:1916-23 (2002)). Another study examining 72 SNPs in 62 candidate genes in individuals with premature MI and controls from the US, showed that three variants in genes encoding thrombosponding-4, thrombospondin-2, and thrombospondin-1, associated with premature MI (Topol, E J, et al  Circulation  104:2641-44 (2001). A more recent study tested 11,053 SNPs in 6,891 genes for association to MI in a group of European-Americans (Shiffman, d., et al  Am J Hum Genet  77:596-605 (2005)). The SNPs tested were primarily selected as variants likely to affect protein function or expression. MI associated variants in four novel genes (KIAA0992, ROS1, TAS2R50, and OR13G1) were identified through this effort. Importantly, variants identified as associated to MI in the above studies remain to be validated in replication studies. Their involvement in the etiology of MI therefore remains uncertain. 
     Recently, genetic susceptibility variants for CAD and MI were identified on chromosome 9, within a region that contains the CDKN2A and CDKN2B genes (Helgadottir, A. et al,  Science  316:1491-93 (2007); McPherson, R. et al,  Science  316:1488-91 (2007); The Wellcome Trust Case Control Consortium,  Nature  447:661-78 (2007); Samani, N J et al,  N Engl J Med  357:443-53 (2007)). Follow-up investigations have shown that the variants, which are all located within a region of high linkage disequilibrium (LD), also contribute to risk of intracranial aneurysm and abdominal aortic aneurysm (Helgadottir, A. et al,  Nature Genet  40:217-24 (2008)), showing that these variants not only contribute to MI and CAD, but also to cardiovascular disease in general. 
     Cardiovascular disease remains the most important cause or morbidity and mortality and there is a large unmet medical need for its prevention. Identifying the key pathways involved in MI and CAD may facilitate development of new therapeutics and diagnostics. Identification of genetic risk factors for MI and CAD may offer clinical practitioners valuable diagnostic and prognostic tools. Genetic variants that are found to be an important key to the presentation of clinical symptoms in MI may also facilitate drug development, through the identification of novel drug targets. 
     There is thus an unmet need for identification of additional genetic variants that confer susceptibility of CAD and MI. The present invention provides such variants. 
     SUMMARY OF THE INVENTION 
     The present invention relates to methods of risk assessment, diagnosis and/or prognosis of coronary artery disease (CAD) and myocardial infarction (MI). Certain genetic variants have been found to be associated with risk of CAD and/or MI. The invention thus relates to methods of assessing increased susceptibility to CAD and/or MI, as well as methods of assessing a decreased susceptibility to CAD and/or MI, or determine a protection against CAD and/or MI. The methods of the invention relate to the evaluation of certain polymorphic markers, as described herein, that have been found to be useful in disease prediction and management, through their association with susceptibility of coronary artery disease and myocardial infarction. 
     In one aspect, the invention relates to a method for determining a susceptibility to coronary artery disease or myocardial infarction in a human individual, comprising determining the presence or absence of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual or in a genotype dataset derived from the individual, wherein the at least one polymorphic marker is selected from the polymorphic markers set forth in Table 4, and markers in linkage disequilibrium therewith, and wherein the presence of the at least one allele is indicative of a susceptibility to coronary artery disease or myocardial infarction. The method may in one embodiment relate to determination of the presence or absence of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual. In another embodiment, the method relates to determination of the presence or absence of at least one allele of at least one polymorphic marker in a genotype dataset derived from the individual. The genotype dataset can be derived from the individual in the sense that the information that it contains (genotype information) relates to a particular nucleic acid sample as a template from a single individual, for whom genetic information is derived. 
     In another aspect, the present invention relates to a method of determining a susceptibility to coronary artery disease or myocardial infarction in a human individual, comprising determining the presence or absence of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual, wherein the at least one polymorphic marker is selected from rs11751605 (SEQ ID NO:1), and markers in linkage disequilibrium therewith, wherein determination of the presence or absence of the at least one allele is indicative of a susceptibility to coronary artery disease or myocardial infarction. In one embodiment, the at least one polymorphic marker is selected from the markers set forth in Table 5, and markers in linkage disequilibrium therewith. 
     In an alternative aspect, the invention relates to a method of diagnosing a susceptibility to coronary artery disease or myocardial infarction in a human individual, the method comprising determining the presence or absence of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual, or in a genotype dataset derived from the individual, wherein the at least one polymorphic marker is selected from rs11751605 (SEQ ID NO:1), and markers in linkage disequilibrium therewith, wherein the presence of the at least one allele is indicative of a susceptibility to coronary artery disease or myocardial infarction. 
     In another aspect, the invention relates to a method of determining a susceptibility to coronary artery disease or myocardial infarction in a human individual, comprising determining whether at least one at-risk allele in at least one polymorphic marker is present in a genotype dataset derived from the individual, wherein the at least one polymorphic marker is selected from the markers set forth in Table 4, and markers in linkage disequilibrium therewith, and wherein determination of the presence of the at least one at-risk allele is indicative of increased susceptibility to coronary artery disease or myocardial infarction in the individual. 
     The genotype dataset comprises in one embodiment information about marker identity, and the allelic status of the individual, i.e. information about the identity of the two alleles carried by the individual for the marker. The genotype dataset may comprise allelic information about one or more marker, including two or more markers, three or more markers, five or more markers, one hundred or more markers, etc. In some embodiments, the genotype dataset comprises genotype information from a whole-genome assessment of the individual including hundreds of thousands of markers, or even one million or more markers. 
     In certain embodiments, the at least one polymorphic marker is selected from the markers set forth in Table 4. In certain other embodiments, the at least one polymorphic marker is associated with the Lipoprotein (a) gene. In certain other embodiments, the at least one polymorphic marker is selected from rs11751605, rs6076623, rs1412444, rs2163612, rs1029396, rs2243547, rs12534186, rs12134779, rs7158073, rs254850, rs2417821, rs7661204, rs4921437, rs832540, rs324594, rs1741318, rs9902941, rs7709212, rs2946534, rs6556861, rs8050136, rs3751812, rs4769613, rs2243548, rs12459084, rs2074464, rs2244871, rs270654, rs854787, rs7944761, rs4779984, rs6502622, rs3183702, rs1433048, rs4925119, rs2476601, rs870347, rs334198, rs854813, rs7753765, rs4925114, rs270661, rs953861, rs10045431, rs8003722, rs2297538, rs12329252, rs3748744, rs4704400, rs3102526, rs2110209, rs1870843 and rs3134517. 
     In one embodiment, the method of determining a susceptibility, or diagnosing a susceptibility of, coronary artery disease or myocardial infarction, further comprises assessing the frequency of at least one haplotype in the individual. In one such embodiment, the at least one haplotype is selected from haplotypes that are in linkage disequilibrium with at least one marker as set forth in Table 4. In another embodiment, the at least one haplotype is selected from the haplotypes that are in linkage disequilibrium with rs11751605 (SEQ ID NO:1). 
     In certain embodiments of the invention, determination of the presence of at least one at-risk allele of at least one polymorphic Marker in a nucleic acid sample from the individual is indicative of an increased susceptibility to coronary artery disease or myocardial infarction. In one embodiment, the increased susceptibility is characterized by a relative risk (RR) or odds ratio (OR) of at least 1.15. In another embodiment, the increased susceptibility is characterized by a relative risk (RR) or odds ratio (OR) of at least 1.20. 
     In some embodiments, the presence of allele C in rs11751605, allele T in rs6076623, allele A in rs1412444, allele G in rs2163612 or allele G in rs1029396 is indicative of increased susceptibility of coronary artery disease or myocardial infarction in the individual. 
     In some other embodiments, the presence of at least one protective allele in a nucleic acid sample from the individual is indicative of a decreased susceptibility of coronary artery disease or myocardial infarction. In another embodiment, the absence of at least one at-risk allele in a nucleic acid sample from the individual is indicative of a decreased susceptibility of coronary artery disease or myocardial infarction. 
     Another aspect of the invention relates to a method of assessing a susceptibility to coronary artery disease or myocardial infarction in a human individual, comprising screening a nucleic acid from the individual for at least one polymorphic marker or haplotype in the genomic segment with the sequence as set forth in any one of SEQ ID NO:1-172 that correlates with increased occurrence of coronary artery disease or myocardial infarction in a human population, wherein the presence of an at-risk marker allele in the at least one polymorphism or an at-risk haplotype in the nucleic acid identifies the individual as having elevated susceptibility to coronary artery disease or myocardial infarction, and wherein the absence of the at least one at-risk marker allele or at-risk haplotype in the nucleic acid identifies the individual as not having the elevated susceptibility. 
     In one such embodiment, the at least one polymorphic marker or haplotype comprises at least one polymorphic marker selected from the markers set forth in Table 4, and polymorphic markers in linkage disequilibrium therewith. 
     Certain embodiments of the invention further comprise a step of screening the nucleic acid for the presence of at least one at-risk genetic variant for a coronary artery disease or myocardial infarction not associated with, i.e. not in linkage disequilibrium with, any one of the markers set forth in Table 4. Such additional genetic variants can in specific embodiments include any variant that has been identified as a susceptibility or risk variant for coronary artery disease or myocardial infarction. 
     In another aspect of the present invention, the presence of the marker or haplotype found to be associated with coronary artery disease or myocardial infarction, and as such useful for determining a susceptibility to coronary artery disease or myocardial infarction, is indicative of a different response rate of the subject to a particular treatment modality for coronary artery disease or myocardial infarction. 
     In another aspect, the invention relates to a method of identification of a marker for use in assessing susceptibility to coronary artery disease or myocardial infarction in human individuals, the method comprising:
         identifying at least one polymorphic marker in linkage disequilibrium with at least one of the markers set forth in Table 4;   determining the genotype status of a sample of individuals diagnosed with, or having a susceptibility to, coronary artery disease or myocardial infarction; and   determining the genotype status of a sample of control individuals;
 
wherein a significant difference in frequency of at least one allele in at least one polymorphism in individuals diagnosed with, or having a susceptibility to, coronary artery disease or myocardial infarction, as compared with the frequency of the at least one allele in the control sample is indicative of the at least one polymorphism being useful for assessing susceptibility to coronary artery disease or myocardial infarction.
       

     In one embodiment, “significant” is determined by statistical means, e.g. the difference is statistically significant. In one such embodiment, statistical significance is characterized by a P-value of less than 0.05. In other embodiments, the statistical significance is characterized a P-value of less than 0.01, less than 0.001, less than 0.0001, less than 0.00001, less than 0.000001, less than 0.0000001, less than 0.0000000001, or less than 0.00000001. 
     In one embodiment, an increase in frequency of the at least one allele in the at least one polymorphism in individuals diagnosed with, or having a susceptibility to, coronary artery disease or myocardial infarction, as compared with the frequency of the at least one allele in the control sample, is indicative of the at least one polymorphism being useful for assessing increased susceptibility to coronary artery disease or myocardial infarction. In another embodiment, a decrease in frequency of the at least one allele in the at least one polymorphism in individuals diagnosed with, or having a susceptibility to, a coronary artery disease or myocardial infarction, as compared with the frequency of the at least one allele in the control sample is indicative of the at least one polymorphism being useful for assessing decreased susceptibility to, or protection against, the coronary artery disease or myocardial infarction. 
     Another aspect of the invention relates to a method of genotyping a nucleic acid sample obtained from a human individual, comprising determining the presence or absence of at least one allele of at least one polymorphic marker in the sample, wherein the at least one marker is selected from the markers set forth in Table 4, and markers in linkage disequilibrium therewith, and wherein determination of the presence or absence of the at least one allele of the at least one polymorphic marker is predictive of a susceptibility of coronary artery disease or myocardial infarction. 
     In one embodiment, genotyping comprises amplifying a segment of a nucleic acid that comprises the at least one polymorphic marker by Polymerase Chain Reaction (PCR), using a nucleotide primer pair flanking the at least one polymorphic marker. In another embodiment, genotyping is performed using a process selected from allele-specific probe hybridization, allele-specific primer extension, allele-specific amplification, nucleic acid sequencing, 5′-exonuclease digestion, molecular beacon assay, oligonucleotide ligation assay, size analysis, and single-stranded conformation analysis. In one particular embodiment, the process comprises allele-specific probe hybridization. In another embodiment, the process comprises DNA sequencing. In a preferred embodiment, the method comprises:
         1) contacting copies of the nucleic acid with a detection oligonucleotide probe and an enhancer oligonucleotide probe under conditions for specific hybridization of the oligonucleotide probe with the nucleic acid;
           wherein   a) the detection oligonucleotide probe is from 5-100 nucleotides in length and specifically hybridizes to a first segment of the nucleic add whose nucleotide sequence is given by any one of SEQ ID NO:1-172 that comprises at least one polymorphic site;   b) the detection oligonucleotide probe comprises a detectable label at its 3′ terminus and a quenching moiety at its 5′ terminus;   c) the enhancer oligonucleotide is from 5-100 nucleotides in length and is complementary to a second segment of the nucleotide sequence that is 5′ relative to the oligonucleotide probe, such that the enhancer oligonucleotide is located 3′ relative to the detection oligonucleotide probe when both oligonucleotides are hybridized to the nucleic acid; and   d) a single base gap exists between the first segment and the second segment, such that when the oligonucleotide probe and the enhancer oligonucleotide probe are both hybridized to the nucleic acid, a single base gap exists between the oligonucleotides;   
           2) treating the nucleic acid with an endonuclease that will cleave the detectable label from the 3′ terminus of the detection probe to release free detectable label when the detection probe is hybridized to the nucleic acid; and   3) measuring free detectable label, wherein the presence of the free detectable label indicates that the detection probe specifically hybridizes to the first segment of the nucleic acid, and indicates the sequence of the polymorphic site as the complement of the detection probe.       

     In a particular embodiment, the copies of the nucleic acid are provided by amplification by Polymerase Chain Reaction (PCR). In another embodiment, the susceptibility determined is increased susceptibility. In another embodiment, the susceptibility determined is decreased susceptibility. 
     Another aspect of the invention relates to a method of assessing an individual for probability of response to a therapeutic agent for preventing and/or ameliorating symptoms associated with coronary artery disease or myocardial infarction, comprising: determining the presence or absence of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual, wherein the at least one polymorphic marker is selected from the markers set forth in Table 4, and markers in linkage disequilibrium therewith, wherein determination of the presence of the at least one allele of the at least one marker is indicative of a probability of a positive response to coronary artery disease or myocardial infarction therapeutic agent. In one embodiment, the at least one polymorphic marker is selected from marker rs11751605, rs6076623, rs1412444, rs2163612 and rs1029396, and markers in linkage disequilibrium therewith. In one embodiment, the therapeutic agent is selected from beta blockers, anticoagulation agents, including heparin and/or low molecular weigh heparin, antiplatelet agents, such as clopidogrel, aspirin, beta blockers, including metoprolol and carvedilol, ACE inhibitors, Statins, Aldosterone antagonists, including eplerenone, leukotriene synthesis inhibitors, the agents set forth in Agent Table I, Agent Table II, (R)-(+)-alpha-cyclopentyl-4-(2-quinolinylmethoxy)-Benzeneacetic acid, atreleuton, and 4-{(S)-2-[4-(4-Chloro-phenoxy)-phenoxymethyl]-pyrrolidin-1-yl}-butyramide, also known as DG-051. Other embodiments may include any one or a combination of the therapeutic agents described herein to be useful for therapeutic intervention of coronary artery disease or myocardial infarction. 
     Yet another aspect of the invention relates to a method of predicting prognosis of an individual diagnosed with coronary artery disease or myocardial infarction, the method comprising determining the presence or absence of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual, wherein the at least one polymorphic marker is selected from the group consisting of the markers set forth in Table 3, and markers in linkage disequilibrium therewith, wherein determination of the presence of the at least one allele is indicative of a worse prognosis of coronary artery disease or myocardial infarction in the individual. The prognosis may in certain embodiment relate to susceptibility of recurrent MI events, recurrent stroke events, or susceptibility to other complications relating to coronary artery disease or myocardial infarction. 
     A further aspect of the invention relates to a method of monitoring progress of a treatment of an individual undergoing treatment for coronary artery disease or myocardial infarction, the method comprising determining the presence or absence of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual, wherein the at least one polymorphic marker is selected from the group consisting of the markers set forth in Table 3, and markers in linkage disequilibrium therewith, wherein determination of the presence of the at least one allele is indicative of the treatment outcome of the individual. The treatment may in certain embodiments be surgical treatment. In other embodiments, the treatment is by administration of a therapeutic agent, optionally including lifestyle changes or alterations in environmental exposure to risk factors for coronary artery disease or myocardial infarction, as described further herein. 
     In one embodiment, the method further comprises assessing at least one biomarker in a sample from the individual. The biomarker is in certain embodiments a cardiac marker or an inflammatory marker. In one embodiment, the at least one biomarker is selected from creatin kinase, troponin, glycogen phosphorylase, C-reactive protein (CRP), serum amyloid A, fibrinogen, interleukin-6, tissue necrosis factor-alpha, soluble vascular cell adhesion molecules (sVCAM), soluble intervascular adhesion molecules (sICAM), E-selectin, matrix metalloprotease type-1, matrix metalloprotease type-2, matrix metalloprotease type-3, matrix metalloprotease type-9, serum sCD40L, leukotrienes, leukotriene metabolites, interleukin-6, tissue necrosis factor-alpha, myeloperoxidase (MPO), and N-tyrosine. In one embodiment, the leukotriene is selected from LTB4, LTC4, LTD4 and LTE4. In another embodiment, the method further comprises analyzing non-genetic information to make risk assessment, diagnosis, or prognosis of the individual. The non-genetic information is in one embodiment selected from age, gender, ethnicity, socioeconomic status, previous disease diagnosis, medical history of subject, family history of coronary artery disease or myocardial infarction, biochemical measurements, and clinical measurements. In a particular preferred embodiment, a further step comprising calculating overall risk is employed. 
     Another aspect of the invention relates to analyzing a sample comprising genomic DNA from a human individual or a genotype dataset derived from a human individual for the presence or absence of at least one at-risk allele of at least one at-risk variant for coronary artery disease or myocardial infarction not in linkage disequilibrium with any one of the markers set forth in Table 4. Thus, the variants described herein to be associated with coronary artery disease or myocardial infarction may be combined with other genetic variants for coronary artery disease or myocardial infarction, that are not genetically related (i.e., not in linkage disequilibrium with) the markers described herein. Such analysis may be undertaken in combination with any of the methods described herein. Furthermore any two markers herein, or any other combination of markers and/or haplotypes described herein to be associated with coronary artery disease or myocardial infarction may be combined to assess an increased susceptibility to coronary artery disease or myocardial infarction. 
     In some embodiments of the methods of the invention, non-genetic information is analyzed, to make risk assessment, diagnosis, or prognosis of the individual. The non-genetic information is in certain embodiments selected from age, gender, ethnicity, socioeconomic status, previous disease diagnosis, medical history of subject, family history of coronary artery disease or myocardial infarction, biochemical measurements, and clinical measurements. Combined genetic factors and/or combinations of genetic and non-genetic factors may be analyzed by known methods, to generate a combined risk. 
     The invention also relates to a kit for assessing susceptibility to a coronary artery disease or myocardial infarction in a human individual, the kit comprising reagents for selectively detecting the presence or absence of at least one allele of at least one polymorphic marker in the genome of the individual, wherein the polymorphic marker is selected from the markers set forth in Table 3, and markers in linkage disequilibrium therewith, and wherein the presence of the at least one allele is indicative of a susceptibility to a coronary artery disease or myocardial infarctions. 
     In one embodiment, the reagents comprise at least one contiguous oligonucleotide that hybridizes to a fragment of the genome of the individual comprising the at least one polymorphic marker, a buffer and a detectable label. In one embodiment, the reagents comprise at least one pair of oligonucleotides that hybridize to opposite strands of a genomic nucleic acid segment obtained from the subject, wherein each oligonucleotide primer pair is designed to selectively amplify a fragment of the genome of the individual that includes one polymorphic marker, and wherein the fragment is at least 30 base pairs in size. In a particular embodiment the at least one oligonucleotide is completely complementary to the genome of the individual. In another embodiment, the at least one oligonucleotide can comprise at least one mismatch to the genome of the individual. In one embodiment, the oligonucleotide is about 18 to about 50 nucleotides in length. In another embodiment, the oligonucleotide is 20-30 nucleotides in length. 
     In one preferred embodiment, the kit comprises: 
     a detection oligonucleotide probe that is from 5-100 nucleotides in length; an enhancer oligonucleotide probe that is from 5-100 nucleotides in length; and an endonuclease enzyme;
 
wherein the detection oligonucleotide probe specifically hybridizes to a first segment of the nucleic acid whose nucleotide sequence is given by any one of SEQ ID NO:1-172 that comprises at least one polymorphic site; and wherein the detection oligonucleotide probe comprises a detectable label at its 3′ terminus and a quenching moiety at its 5′ terminus; wherein the enhancer oligonucleotide is from 5-100 nucleotides in length and is complementary to a second segment of the nucleotide sequence that is 5′ relative to the oligonucleotide probe, such that the enhancer oligonucleotide is located 3′ relative to the detection oligonucleotide probe when both oligonucleotides are hybridized to the nucleic acid; wherein a single base gap exists between the first segment and the second segment, such that when the oligonucleotide probe and the enhancer oligonucleotide probe are both hybridized to the nucleic acid, a single base gap exists between the oligonucleotides; and wherein treating the nucleic acid with the endonuclease will cleave the detectable label from the 3′ terminus of the detection probe to release free detectable label when the detection probe is hybridized to the nucleic acid.
 
     A further aspect of the invention relates to the use of an oligonucleotide probe in the manufacture of a diagnostic reagent for diagnosing and/or assessing susceptibility to coronary artery disease or myocardial infarction in a human individual, wherein the probe hybridizes to a segment of a nucleic acid whose nucleotide sequence is given by any one of SEQ ID NO:1-172 that comprises at least one polymorphic site, wherein the fragment is 15-500 nucleotides in length. In one embodiment, the polymorphic site is selected from the polymorphic markers rs11751605, rs6076623, rs1412444, rs2163612 and rs1029396, and markers in linkage disequilibrium therewith 
     Yet another aspect of the invention relates to a computer-readable medium on which is stored: an identifier for at least one polymorphic marker; an indicator of the frequency of at least one allele of said at least one polymorphic marker in a plurality of individuals diagnosed with a coronary artery disease or myocardial infarction; and an indicator of the frequency of the least one allele of said at least one polymorphic markers in a plurality of reference individuals; wherein the at least one polymorphic marker is selected from the polymorphic markers set forth in Table 4, and markers in linkage disequilibrium therewith. In one embodiment, the at least one polymorphic marker is selected from rs11751605, rs6076623, rs1412444, rs2163612, rs1029396, and markers in linkage disequilibrium therewith. 
     Another aspect relates to an apparatus for determining a genetic indicator for coronary artery disease or myocardial infarction in a human individual, comprising: a computer readable memory; and a routine stored on the computer readable memory; wherein the routine is adapted to be executed on a processor to analyze marker and/or haplotype information for at least one human individual with respect to at least one polymorphic marker selected from the markers set forth in Table 4, and markers in linkage disequilibrium therewith, and generate an output based on the marker or haplotype information, wherein the output comprises a risk measure of the at least one marker or haplotype as a genetic indicator of coronary artery disease or myocardial infarction for the human individual. 
     In one embodiment, the routine further comprises an indicator of the frequency of at least one allele of at least one polymorphic marker or at least one haplotype in a plurality of individuals diagnosed with coronary artery disease or myocardial infarction, and an indicator of the frequency of at the least one allele of at least one polymorphic marker or at least one haplotype in a plurality of reference individuals, and wherein a risk measure is based on a comparison of the at least one marker and/or haplotype status for the human individual to the indicator of the frequency of the at least one marker and/or haplotype information for the plurality of individuals diagnosed with coronary artery disease or myocardial infarction. 
     The present invention, as described herein, may be reduced to practice using any one, or a combination of, the polymorphic markers described herein as being useful for the determination of a susceptibility to coronary artery disease or myocardial infarction. This includes markers that are shown herein to be associated with coronary artery disease or myocardial infarction, but also includes markers that are in linkage disequilibrium with such variants. In one embodiment, the at least one marker is selected from the markers set forth in Table 3. In another embodiment, the at least one marker is selected from the markers set forth in Table 4. In another embodiment, the at least one marker is selected from rs11751605 (SEQ ID NO:1), rs6076623 (SEQ ID NO:2), rs1412444 (SEQ ID NO:3), rs2163612 (SEQ ID NO:4), rs1029396 (SEQ ID NO:5), rs2243547 (SEQ ID NO:6), rs12534186 (SEQ ID NO:7), rs12134779 (SEQ ID NO:8), rs7158073 (SEQ ID NO:9), rs254850 (SEQ ID NO:10), rs2417821 (SEQ ID NO:11), rs7661204 (SEQ ID NO:12), rs4921437 (SEQ ID NO:13), rs832540 (SEQ ID NO:14), rs324594 (SEQ ID NO:15), rs1741318 (SEQ ID NO:16), rs9902941 (SEQ ID NO:17), rs7709212 (SEQ ID NO:18), rs2946534 (SEQ ID NO:19), rs6556861 (SEQ ID NO:20), rs8050136 (SEQ ID NO:21), rs3751812 (SEQ ID NO:22), rs4769613 (SEQ ID NO:23), rs2243548 (SEQ ID NO:24), rs12459084 (SEQ ID NO:25), rs2074464 (SEQ ID NO:26), rs2244871 (SEQ ID NO:27), rs270654 (SEQ ID NO:28), rs854787 (SEQ ID NO:29), rs7944761 (SEQ ID NO:30), rs4779984 (SEQ ID NO:31), rs6502622 (SEQ ID NO:32), rs3183702 (SEQ ID NO:33), rs1433048 (SEQ ID NO:34), rs4925119 (SEQ ID NO:35), rs2476601 (SEQ ID NO:36), rs870347 (SEQ ID NO:37), rs334198 (SEQ ID NO:38), rs854813 (SEQ ID NO:39), rs7753765 (SEQ ID NO:40), rs4925114 (SEQ ID NO:41), rs270661 (SEQ ID NO:42), rs953861 (SEQ ID NO:43), rs10045431 (SEQ ID NO:44), rs8003722 (SEQ ID NO:45), rs2297538 (SEQ ID NO:46), rs12329252 (SEQ ID NO:47), rs3748744 (SEQ ID NO:48), rs4704400 (SEQ ID NO:49), rs3102526 (SEQ ID NO:50), rs2110209 (SEQ ID NO:51), rs1870843 (SEQ ID NO:52) and rs3134517 (SEQ ID NO:53). In another embodiment, the at least one marker is selected from rs11751605 (SEQ ID NO:1), rs6076623 (SEQ ID NO:2), rs1412444 (SEQ ID NO:3), rs2163612 (SEQ ID NO:4), rs1029396 (SEQ ID NO:5). In another embodiment, the at least one marker is selected from rs11751605 (SEQ ID NO:1), rs6076623 (SEQ ID NO:2), rs1412444 (SEQ ID NO:3), rs2163612 (SEQ ID NO:4), rs1029396 (SEQ ID NO:5), rs2243547 (SEQ ID NO:6), rs12534186 (SEQ ID NO:7), rs12134779 (SEQ ID NO:8), rs7158073 (SEQ ID NO:9). In another embodiment, the at least one marker is rs11751605 (SEQ ID NO:1). In another embodiment, the at least one marker is rs6076623 (SEQ ID NO:2). In another embodiment, the at least one marker is rs1412444 (SEQ ID NO:3). In another embodiment, the at least one marker is rs2163612 (SEQ ID NO:4). In another embodiment, the at least one marker is rs1029396 (SEQ ID NO:5). In these embodiments, the at least one marker may optionally be selected from markers in linkage disequilibrium with the at least one marker. 
     The present invention relates to methods, uses, apparatus or kits useful for detecting or determining a susceptibility to myocardial infarction or coronary artery disease. It is however contemplated that the variants described herein to be correlated with risk of developing myocardial infarction or coronary artery disease may also be risk variants for other cardiovascular diseases. This includes Stroke, Peripheral Artery Disease, Restenosis, Intracranial Aneurysm and Aorta Abdominal Aneurysm. The Restenosis phenotype may for example be Coronary In-stent Restenosis. The In-stent Restenosis may further be either Restenosis following Bare Metal Stent (BMS) placement, or Restenosis following placement of a Drug Eluting Stent (DES). 
     Variants (markers and/or haplotypes comprising polymorphic markers) in linkage disequilibrium with the markers and haplotypes of the present invention are also useful for the methods and kits of the invention. The invention therefore also pertains to markers in linkage disequilibrium with the markers and haplotypes of the invention. In certain embodiments of the methods, uses, apparatus or kits of the invention, linkage disequilibrium is characterized by specific cutoff values for a quantitative measure of linkage disequilibrium. In one such embodiment, linkage disequilibrium is characterized by specific numerical values, or ranges of numerical values, for r 2 . In another such embodiment, linkage disequilibrium is characterized by specific numerical values, or ranges of numerical values, for |D′|. In yet another embodiment, linkage disequilibrium is characterized by specific numerical values for r 2  and |D′|, or ranges thereof. In one preferred embodiment, linkage disequilibrium is characterized by values for r 2  of greater than 0.1. In another preferred embodiment, linkage disequilibrium is characterized by values for r 2  of greater than 0.2. Other cutoff values for r 2  are also possible, including, but not limited to, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 0.95, 0.96, 0.97, 0.98, 0.99. In another preferred embodiment, linkage disequilibrium is characterized by values for |D′| of greater than 0.5. In another preferred embodiment, linkage disequilibrium is characterized by values for |D′| of greater than 0.8. Other cutoff values for |D′| are also possible, including, but not limited to, 0.2, 0.3, 0.4, 0.6, 0.7, 0.8, 0.9, 0.95, 0.96, 0.97, 0.98 and 0.99. In certain embodiments, linkage disequilibrium is characterized by numeric cutoff values for either |D′| and r 2 . In one such embodiment linkage disequilibrium is characterized by numerical values for either |D′| of greater than 0.8 and r 2  of greater than 0.2, or both. 
     In certain other embodiments of the methods, uses, apparatus or kits of the invention, the individual is of a specific human ancestry. In one embodiment, the ancestry is selected from black African ancestry, Caucasian ancestry and Chinese ancestry. In another embodiment, the ancestry is black African ancestry. In another embodiment, the ancestry is African American ancestry. In another embodiment, the ancestry is European ancestry. In another embodiment, the ancestry is Caucasian ancestry. The ancestry is in certain embodiment self-reported by the individual who undergoes genetic analysis or genotyping. In other embodiments, the ancestry is determined by genetic determination comprising detecting at least one allele of at least one polymorphic marker in a nucleic acid sample from the individual, wherein the presence or absence of the allele is indicative of the ancestry of the individual. 
     In other particular other embodiments of the methods, uses, apparatus or kits of the invention, the presence of at least one at-risk variant, i.e. an at-risk allele in at least one polymorphic marker or an at-risk haplotype, is indicative of an early onset of coronary artery disease or myocardial infarction. Early onset is in some embodiments categorized as onset before age 75. In other embodiments, early onset is categorized as onset before age 70, before age 65, before age 60, before age 55, before age 50, before age 45, or before age 40. Other values for categorization of age at onset are also contemplated, including, but not limited to, all integer values of age, and such age categories are also within scope of the invention. In certain embodiments, the age at onset is below 50 for males and/or below 60 for females. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     Definitions 
     Unless otherwise indicated, nucleic acid sequences are written left to right in a 5′ to 3′ orientation. Numeric ranges recited within the specification are inclusive of the numbers defining the range and include each integer or any non-integer fraction within the defined range. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by the ordinary person skilled in the art to which the invention pertains. 
     The following terms shall, in the present context, have the meaning as indicated: 
     A “polymorphic marker”, sometime referred to as a “marker”, as described herein, refers to a genomic polymorphic site. Each polymorphic marker has at least two sequence variations characteristic of particular alleles at the polymorphic site. Thus, genetic association to a polymorphic marker implies that there is association to at least one specific allele of that particular polymorphic marker. The marker can comprise any allele of any variant type found in the genome, including SNPs, microsatellites, insertions, deletions, duplications and translocations. 
     An “allele” refers to the nucleotide sequence of a given locus (position) on a chromosome. A polymorphic marker allele thus refers to the composition (i.e., sequence) of the marker on a chromosome. Genomic DNA from an individual contains two alleles (e.g., allele-specific sequences) for any given polymorphic marker, representative of each copy of the marker on each chromosome. Sequence codes for nucleotides used herein are: A=1, C=2, G=3, T=4. For microsatellite alleles, the CEPH sample (Centre d′Etudes du Polymorphisme Humain, genomics repository, CEPH sample 1347-02) is used as a reference, the shorter allele of each microsatellite in this sample is set as 0 and all other alleles in other samples are numbered in relation to this reference. Thus, e.g., allele 1 is 1 by longer than the shorter allele in the CEPH sample, allele 2 is 2 by longer than the shorter allele in the CEPH sample, allele 3 is 3 by longer than the lower allele in the CEPH sample, etc., and allele −1 is 1 by shorter than the shorter allele in the CEPH sample, allele −2 is 2 by shorter than the shorter allele in the CEPH sample, etc. 
     Sequence conucleotide ambiguity as described herein is as proposed by IUPAC-IUB. These codes are compatible with the codes used by the EMBL, GenBank, and PIR databases. 
     
       
         
           
               
               
             
               
                   
               
               
                 IUB code 
                 Meaning 
               
               
                   
               
             
            
               
                 A 
                 Adenosine 
               
               
                 C 
                 Cytidine 
               
               
                 G 
                 Guanine 
               
               
                 T 
                 Thymidine 
               
               
                 R 
                 G or A 
               
               
                 Y 
                 T or C 
               
               
                 K 
                 G or T 
               
               
                 M 
                 A or C 
               
               
                 S 
                 G or C 
               
               
                 W 
                 A or T 
               
               
                 B 
                 C G or T 
               
               
                 D 
                 A G or T 
               
               
                 H 
                 A C or T 
               
               
                 V 
                 A C or G 
               
               
                 N 
                 A C G or T (Any base) 
               
               
                   
               
            
           
         
       
     
     A nucleotide position at which more than one sequence is possible in a population (either a natural population or a synthetic population, e.g., a library of synthetic molecules) is referred to herein as a “polymorphic site”. 
     A “Single Nucleotide Polymorphism” or “SNP” is a DNA sequence variation occurring when a single nucleotide at a specific location in the genome differs between members of a species or between paired chromosomes in an individual. Most SNP polymorphisms have two alleles. Each individual is in this instance either homozygous for one allele of the polymorphism (i.e. both chromosomal copies of the individual have the same nucleotide at the SNP location), or the individual is heterozygous (i.e. the two sister chromosomes of the individual contain different nucleotides). The SNP nomenclature as reported herein refers to the official Reference SNP (rs) ID identification tag as assigned to each unique SNP by the National Center for Biotechnological Information (NCBI). 
     A “variant”, as described herein, refers to a segment of DNA that differs from the reference DNA. A “marker” or a “polymorphic marker”, as defined herein, is a variant. Alleles that differ from the reference are referred to as “variant” alleles. 
     A “microsatellite” is a polymorphic marker that has multiple small repeats of bases that are 2-8 nucleotides in length (such as CA repeats) at a particular site, in which the number of repeat lengths varies in the general population. An “indel” is a common form of polymorphism comprising a small insertion or deletion that is typically only a few nucleotides long. 
     A “haplotype,” as described herein, refers to a segment of genomic DNA that is characterized by a specific combination of alleles arranged along the segment. For diploid organisms such as humans, a haplotype comprises one member of the pair of alleles for each polymorphic marker or locus. In a certain embodiment, the haplotype can comprise two or more alleles, three or more alleles, four or more alleles, or five or more alleles. 
     The term “susceptibility”, as described herein, refers to the proneness of an individual towards the development of a certain state (e.g., a certain trait, phenotype or disease), or towards being less able to resist a particular state than the average individual. The term encompasses both increased susceptibility and decreased susceptibility. Thus, particular polymorphic markers and/or haplotypes of the invention may be characteristic of increased susceptibility (i.e., increased risk) of coronary artery disease and myocardial infarction, as characterized by a relative risk (RR) or odds ratio (OR) of greater than one for the particular allele or haplotype. Alternatively, the markers and/or haplotypes of the invention are characteristic of decreased susceptibility (i.e., decreased risk) of coronary artery disease and myocardial infarction, as characterized by a relative risk of less than one. 
     The term “and/or” shall in the present context be understood to indicate that either or both of the items connected by it are involved. In other words, the term herein shall be taken to mean “one or the other or both”. 
     The term “look-up table”, as described herein, is a table that correlates one form of data to another form, or one or more forms of data to a predicted outcome to which the data is relevant, such as phenotype or trait. For example, a look-up table can comprise a correlation between allelic data for at least one polymorphic marker and a particular trait or phenotype, such as a particular disease diagnosis, that an individual who comprises the particular allelic data is likely to display, or is more likely to display than individuals who do not comprise the particular allelic data. Look-up tables can be multidimensional, i.e. they can contain information about multiple alleles for single markers simultaneously, or the can contain information about multiple markers, and they may also comprise other factors, such as particulars about diseases diagnoses, racial information, biomarkers, biochemical measurements, therapeutic methods or drugs, etc. 
     A “computer-readable medium”, is an information storage medium that can be accessed by a computer using a commercially available or custom-made interface. Exemplary compute-readable media include memory (e.g., RAM, ROM, flash memory, etc.), optical storage media (e.g., CD-ROM), magnetic storage media (e.g., computer hard drives, floppy disks, etc.), punch cards, or other commercially available media. Information may be transferred between a system of interest and a medium, between computers, or between computers and the computer-readable medium for storage or access of stored information. Such transmission can be electrical, or by other available methods, such as IR links, wireless connections, etc. 
     A “nucleic acid sample”, as described herein, refers to a sample obtained from an individuals that contains nucleic acid. In certain embodiments, i.e. the detection of specific polymorphic markers and/or haplotypes, the nucleic acid sample comprises genomic DNA. Such a nucleic acid sample can be obtained from any source that contains genomic DNA, including as a blood sample, sample of amniotic fluid, sample of cerebrospinal fluid, or tissue sample from skin, muscle, buccal or conjunctival mucosa, placenta, gastrointestinal tract or other organs. 
     The term “CAD and/or MI therapeutic agent”, as described herein, refers to an agent that can be used to ameliorate or prevent symptoms associated with coronary artery disease or myocardial infarction. Such agents can for example be statins, beta blockers, calcium channel blockers, cardiac glycosides, antihypertensive agents, diuretics, agents acting on the renin-angiotensin system, and aspirin, or other therapeutic agents as described herein. 
     The term “CAD and/or MI-associated nucleic acid”, as described herein, refers to a nucleic acid that has been found to be associated to coronary artery disease and myocardial infarction. This includes, but is not limited to, the markers and haplotypes described herein and markers and haplotypes in linkage disequilibrium (LD) therewith. 
     The term “early onset”, as described herein, refers to onset of a disease that is lower than is typically observed. Fore example, in certain embodiments as applied to the MI phenotype, “early onset” can be defined as a MI event before the age of 50 for males and before the age of 60 for females. However, the term can be defined using other age cutoffs, as is deemed appropriate by the skilled person, and should in the present context be taken to mean age of onset of the disease that is lower than one would typically observe, and consequently considered early. 
     Association of Genetic Variants to Coronary Artery Disease and Myocardial Infarction 
     Through a genome-wide association search for variants contributing to increased risk of developing coronary artery disease (CAD) and myocardial infarction (MI), a number of SNP variants have been found to be associated with MI and CAD. These variants, (see Table 1), and variants in linkage disequilibrium with the identified variants, can be used to assess risk of developing CAD or MI in an individual, by determining the genotype of the individual for the individual variants. Haplotypes comprising the variants of the present invention, or haplotypes in LD with the variants of the invention, can also be used to assess risk of developing CAD or MI. 
     The genome-wide scan was expanded to a larger discovery cohort and the analysis repeated (Table 3). Most of the SNPs showing association in the discovery sample were investigated in six replication cohorts, from Durham (NC), Atlanta (GA), Philadelphia (PA), and Johns Hopkins (MD) in the United States, from Italy and from the Wellcome Trust Case Control Consortium (WTCCC). As shown in Table 4, several variants show evidence for association in the replication samples, in particular markers rs11751605, rs6076623, rs1412444, rs2163612 and rs1029396. These markers are therefore particularly useful in the methods, uses, apparatus and kits described further herein. The association of marker rs11751605 is particularly significant; the overall P-value of association for this marker to CAD is 1.16×10 −8 , which is genome-wide significant after correcting for the number of tests performed (Bonferroni correction gives 0.05/300,000˜1.7×10 −7 ). 
     Markers in linkage disequilibrium with any one of rs11751605, rs6076623, rs1412444, rs2163612 and rs1029396 are also useful in the methods, uses, kits and apparatus of the invention. Markers in LD with rs11751605 are particularly useful. Surrogate markers for rs11751605, based on r 2  values in the Hapmap Caucasian CEU sample of greater than 0.2). 
     The marker rs11751605 is located on Chromosome 6, near the 5′ end of the Lipoprotein(a) gene (also called Lp(a)). The Lp(a) gene encodes a lipoprotein in a subclass consisting of an LDL-like particle and the specific apolipoprotein(a) [apo(a)], which is covalently bound to the apoB of the LDL-like particle. 
     Apo(a) proteins vary in size due to a size polymorphism [KIV-2 VNTR], which is caused by a variable number of so called kringle IV repeats in the LPA gene. These variable apo(a) sizes are known as “apo(a) isoforms”. There is a general inverse correlation between the size of the apo(a) isoform and the Lp(a) plasma concentration 
     Lp(a) concentrations are highly heritable and vary over one thousandfold between individuals, from &lt;0.2 to &gt;200 mg/dL. Lp(a) plasma concentrations is mainly controlled by the apolipoprotein(a) gene (LPA) located on chromosome 6q26-27. However, the apo(a) size polymorphism does not explain all the interindividual variation in Lp(a) levels in plasma. For alleles with identical number of K IV repeats, the Lp(a) level can vary by a factor of 200. Additional polymorphisms (independent from the K IV size polymorphism) in the gene have been shown to affect the Lp(a) concentration (Human Molecular Genetics, 2001, 10: 815-824). Therefore, the genetic determination of Lp(a) levels is highly complex and currently not fully understood. 
     Lipoprotein structure is similar to plasminogen and tPA (tissue plasminogen activator) and it has been shown to affect (reduce) fibrinolysis and (increase) thrombogenesis. In addition, the LDL cholesterol content of Lp-a contributes to atherosclerosis. 
     High Lp(a) in blood has been shown to be a risk factor for coronary heart disease (CHD), cerebrovascular disease (CVD), atherosclerosis, thrombosis, and stroke. However, few reported studies have investigated the association between genetic variants that affect Lp(a) concentration and coronary artery disease. The frequency of small apo(a) isoforms has been shown to be higher in patients with myocardial infarction compared with healthy controls (Atheroslerosis 144:323-333 (1999)) and another study has shown the isoforms to be higher in those with advanced atherosclerosis of the carotid arteries compared to those without advanced atherosclerosis (Circulation 100:1154-1160 (1999)). 
     A recent study reported that a single nucleotide polymorphism (rs3798220) in the coding sequence of the LPA gene associated with severe coronary artery disease and Lp(a) levels (Arterioscler Thromb Vasc Biol 27:2030-2036 (2007)). The rs11751605 marker is however not correlated with rs3798220. In a sample of over 5000 Icelanders genotyped for both markers, the at-risk allele of rs3798220 does not lie on the haplotype background of the risk allele rs11751605 (r 2 =0.002). In other words, the at-risk allele of rs3798220 and the at-risk allele of rs11751605 reside on different chromosomal backgrounds, and they are thus not inherited together. As a consequence, these signals are unrelated. The allelic frequency of rs11751605 allele C (the at-risk allele) is 11%, the frequency of rs3798220 allele C (the reported at-risk allele) is 1.5%, whereas their joint frequency is zero. 
     Thus, the association observed for rs11751605 is clearly not due to, or correlated to, rs3798220. Moreover, the rs3798220 C allele found to associate with Lp(a) levels is very rare (1.5%), whereas the at-risk C allele of rs11751605 is relatively common (11%), thus explaining a higher proportion of the risk conferred by the variant for MI and CAD susceptibility. It is at present not known if the rs11751605 marker correlates with Lp(a) levels in plasma. 
     It is important to note that correlation of a certain disease (MI or CAD, for example) to certain biological risk factors (biomarkers or related traits) does not, in general translate into association of the disease to markers in the gene encoding the biomarker. Moreover, genetic risk for a confounding trait or disease, or a known risk factor for a disease, does not necessarily translate into shared genetic effects. Many such examples are known from diseases such as type 2 diabetes, LDL cholesterol and obesity, which all have observable effects on the risk of CAD. For example, the strongest genetic risk factor for type II diabetes (in the TCF7L2 gene) does not show any association with MI. The markers rs693 and rs562338, located within the ApoB locus, have been shown to strongly correlate with LDL cholesterol levels (Nature Genet. 40:161-9 (2008)), yet these markers do not show any association with CAD. In addition, genetic markers within the FTO gene that have been shown to associate with obesity are not associated with CAD. 
     Thus, even in light of the prior knowledge of the correlation of Lp(a) levels with risk of CAD and MI, and the identification of genetic variants within the Lp(a) gene with Lp(a) levels, it would by no means have been obvious that genetic variants within the gene confer risk of MI or CAD. If this were the case, such a genetic relationship would presumably have been established much earlier. The present finding of an association between rs11751605 and risk of CAD and MI is thus very surprising. 
     Assessment for Markers and Haplotypes 
     The genomic sequence within populations is not identical when individuals are compared. Rather, the genome exhibits sequence variability between individuals at many locations in the genome. Such variations in sequence are commonly referred to as polymorphisms, and there are many such sites within each genome. For example, the human genome exhibits sequence variations which occur on average every 500 base pairs. The most common sequence variant consists of base variations at a single base position in the genome, and such sequence variants, or polymorphisms, are commonly called Single Nucleotide Polymorphisms (“SNPs”). These SNPs are believed to have occurred in a single mutational event, and therefore there are usually two possible alleles possible at each SNPsite; the original allele and the mutated allele. Due to natural genetic drift and possibly also selective pressure, the original mutation has resulted in a polymorphism characterized by a particular frequency of its alleles in any given population. Many other types of sequence variants are found in the human genome, including microsatellites, insertions, deletions, inversions and copy number variations. A polymorphic microsatellite has multiple small repeats of bases (such as CA repeats, TG on the complimentary strand) at a particular site in which the number of repeat lengths varies in the general population. In general terms, each version of the sequence with respect to the polymorphic site represents a specific allele of the polymorphic site. These sequence variants can all be referred to as polymorphisms, occurring at specific polymorphic sites characteristic of the sequence variant in question. In general terms, polymorphisms can comprise any number of specific alleles. Thus in one embodiment of the invention, the polymorphism is characterized by the presence of two or more alleles in any given population. In another embodiment, the polymorphism is characterized by the presence of three or more alleles. In other embodiments, the polymorphism is characterized by four or more alleles, five or more alleles, six or more alleles, seven or more alleles, nine or more alleles, or ten or more alleles. All such polymorphisms can be utilized in the methods and kits of the present invention, and are thus within the scope of the invention. 
     In some instances, reference is made to different alleles at a polymorphic site without choosing a reference allele. Alternatively, a reference sequence can be referred to for a particular polymorphic site. The reference allele is sometimes referred to as the “wild-type” allele and it usually is chosen as either the first sequenced allele or as the allele from a “non-affected” individual (e.g., an individual that does not display a trait or disease phenotype). Alleles for SNP markers as referred to herein refer to the bases A, C, G or T as they occur at the polymorphic site in the SNP assay employed. The allele codes for SNPs used herein are as follows: 1=A, 2=C, 3=G, 4=T. The person skilled in the art will however realise that by assaying or reading the opposite DNA strand, the complementary allele can in each case be measured. Thus, for a polymorphic site (polymorphic marker) containing an A/G polymorphism, the assay employed may either measure the percentage or ratio of the two bases possible, i.e. A and G. Alternatively, by designing an assay that determines the opposite strand on the DNA template, the percentage or ratio of the complementary bases T/C can be measured. Quantitatively (for example, in terms of relative risk), identical results would be obtained from measurement of either DNA strand (+strand or −strand). 
     Typically, a reference sequence is referred to for a particular sequence. Alleles that differ from the reference are referred to as “variant” alleles. A variant sequence, as used herein, refers to a sequence that differs from the reference sequence but is otherwise substantially similar. Alleles at the polymorphic genetic markers that make up the haplotypes described herein are variants. Additional variants can include changes that affect a polypeptide. Sequence differences, when compared to a reference nucleotide sequence, can include the insertion or deletion of a single nucleotide, or of more than one nucleotide, resulting in a frame shift; the change of at least one nucleotide, resulting in a change in the encoded amino acid; the change of at least one nucleotide, resulting in the generation of a premature stop codon; the deletion of several nucleotides, resulting in a deletion of one or more amino acids encoded by the nucleotides; the insertion of one or several nucleotides, such as by unequal recombination or gene conversion, resulting in an interruption of the coding sequence of a reading frame; duplication of all or a part of a sequence; transposition; or a rearrangement of a nucleotide sequence, as described in detail herein. Such sequence changes alter the polypeptide encoded by the nucleic acid. For example, if the change in the nucleic acid sequence causes a frame shift, the frame shift can result in a change in the encoded amino acids, and/or can result in the generation of a premature stop codon, causing generation of a truncated polypeptide. Alternatively, a polymorphism associated with coronary artery disease and myocardial infarction or a susceptibility to coronary artery disease and myocardial infarction can be a synonymous change in one or more nucleotides (i.e., a change that does not result in a change in the amino acid sequence). Such a polymorphism can, for example, alter splice sites, affect the stability or transport of mRNA, or otherwise affect the transcription or translation of an encoded polypeptide. It can also alter DNA to increase the possibility that structural changes, such as amplifications or deletions, occur at the somatic level. The polypeptide encoded by the reference nucleotide sequence is the “reference” polypeptide with a particular reference amino acid sequence, and polypeptides encoded by variant alleles are referred to as “variant” polypeptides with variant amino acid sequences. 
     A haplotype refers to a segment of DNA that is characterized by a specific combination of alleles arranged along the segment. For diploid organisms such as humans, a haplotype comprises one member of the pair of alleles for each polymorphic marker or locus. In a certain embodiment, the haplotype can comprise two or more alleles, three or more alleles, four or more alleles, or five or more alleles, each allele corresponding to a specific polymorphic marker along the segment. Haplotypes can comprise a combination of various polymorphic markers, e.g., SNPs and microsatellites, having particular alleles at the polymorphic sites. The haplotypes thus comprise a combination of alleles at various genetic markers. 
     Detecting specific polymorphic markers and/or haplotypes can be accomplished by methods known in the art for detecting sequences at polymorphic sites. For example, standard techniques for genotyping for the presence of SNPs and/or microsatellite markers can be used, such as fluorescence-based techniques (e.g., Chen, X. et al.,  Genome Res.  9(5): 492-98 (1999); Kutyavin et al.,  Nucleic Acid Res.  34:e128 (2006)), utilizing PCR, LCR, Nested PCR and other techniques for nucleic acid amplification. Specific methodologies available for SNP genotyping include, but are not limited to, TaqMan genotyping assays and SNPlex platforms (Applied Biosystems), mass spectrometry (e.g., MassARRAY system from Sequenom), minisequencing methods, real-time PCR, Bio-Plex system (BioRad), CEQ and SNPstream systems (Beckman), Molecular Inversion Probe array technology (e.g., Affymetrix GeneChip), and BeadArray Technologies (e.g., Illumina GoldenGate and Infinium assays). By these or other methods available to the person skilled in the art, one or more alleles at polymorphic markers, including microsatellites, SNPs or other types of polymorphic markers, can be identified. 
     In certain methods described herein, an individual who is at an increased susceptibility (i.e., at risk) for Coronary Artery Disease and myocardial infarction is an individual in whom at least one specific allele at one or more polymorphic marker or haplotype conferring increased susceptibility for Coronary Artery Disease and myocardial infarction is identified (i.e., at-risk marker alleles or haplotypes). In one aspect, the at-risk marker or haplotype is one that confers a significant increased risk (or susceptibility) of coronary artery disease and myocardial infarction. In one embodiment, significance associated with a marker or haplotype is measured by a relative risk (RR). In another embodiment, significance associated with a marker or haplotype is measured by an odds ratio (OR). In a further embodiment, the significance is measured by a percentage. In one embodiment, a significant increased risk is measured as a risk (relative risk and/or odds ratio) of at least 1.2, including but not limited to: at least 1.2, at least 1.3, at least 1.4, at least 1.5, at least 1.6, at least 1.7, 1.8, at least 1.9, at least 2.0, at least 2.5, at least 3.0, at least 4.0, and at least 5.0. In a particular embodiment, a risk (relative risk and/or odds ratio) of at least 1.2 is significant. In another particular embodiment, a risk of at least 1.3 is significant. In yet another embodiment, a risk of at least 1.4 is significant. In a further embodiment, a relative risk of at least 1.5 is significant. In another further embodiment, a significant increase in risk is at least 1.7 is significant. However, other cutoffs are also contemplated, e.g., at least 1.15, 1.25, 1.35, and so on, and such cutoffs are also within scope of the present invention. In other embodiments, a significant increase in risk is at least about 20%, including but not limited to about 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 100%, 150%, 200%, 300%, and 500%. In one particular embodiment, a significant increase in risk is at least 20%. In other embodiments, a significant increase in risk is at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90% and at least 100%. Other cutoffs or ranges as deemed suitable by the person skilled in the art to characterize the invention are however also contemplated, and those are also within scope of the present invention. In certain embodiments, a significant increase in risk is characterized by a p-value, such as a p-value of less than 0.05, less than 0.01, less than 0.001, less than 0.0001, less than 0.00001, less than 0.000001, less than 0.0000001, less than 0.00000001, or less than 0.000000001. 
     An at-risk polymorphic marker or haplotype of the present invention is one where at least one allele of at least one marker or haplotype is more frequently present in an individual at risk for the disease or trait (affected), compared to the frequency of its presence in a comparison group (control), and wherein the presence of the marker or haplotype is indicative of susceptibility to coronary artery disease and/or myocardial infarction. The control group may in one embodiment be a population sample, i.e. a random sample from the general population. In another embodiment, the control group is represented by a group of individuals who are disease-free. Such disease-free control may in one embodiment be characterized by the absence of one or more specific disease-associated symptoms. In another embodiment, the disease-free control group is characterized by the absence of one or more disease-specific risk factors. Such risk factors are in one embodiment at least one environmental risk factor. Representative environmental factors are natural products, minerals or other chemicals which are known to affect, or contemplated to affect, the risk of developing the specific disease or trait. Other environmental risk factors are risk factors related to lifestyle, including but not limited to food and drink habits, geographical location of main habitat, and occupational risk factors. In another embodiment, the risk factors comprise at least one additional genetic risk factor. 
     As an example of a simple test for correlation would be a Fisher-exact test on a two by two table. Given a cohort of chromosomes, the two by two table is constructed out of the number of chromosomes that include both of the markers or haplotypes, one of the markers or haplotypes but not the other and neither of the markers or haplotypes. Other statistical tests of association known to the skilled person are also contemplated and are also within scope of the invention. 
     In other embodiments of the invention, an individual who is at a decreased susceptibility (i.e., at a decreased risk) for coronary artery disease and/or myocardial infarction is an individual in whom at least one specific allele at one or more polymorphic marker or haplotype conferring decreased susceptibility for coronary artery disease and myocardial infarction is identified. The marker alleles and/or haplotypes conferring decreased risk are also said to be protective. In one aspect, the protective marker or haplotype is one that confers a significant decreased risk (or susceptibility) of coronary artery disease and myocardial infarction. In one embodiment, significant decreased risk is measured as a relative risk (or odds ratio) of less than 0.9, including but not limited to less than 0.9, less than 0.8, less than 0.7, less than 0.6, less than 0.5, less than 0.4, less than 0.3, less than 0.2 and less than 0.1. In one particular embodiment, significant decreased risk is less than 0.7. In another embodiment, significant decreased risk is less than 0.5. In yet another embodiment, significant decreased risk is less than 0.3. In another embodiment, the decrease in risk (or susceptibility) is at least 20%, including but not limited to at least 25%, at least 30%, at least 35%, at least 40%, at least 45%, at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95% and at least 98%. In one particular embodiment, a significant decrease in risk is at least about 30%. In another embodiment, a significant decrease in risk is at least about 50%. In another embodiment, the decrease in risk is at least about 70%. Other cutoffs or ranges as deemed suitable by the person skilled in the art to characterize the invention are however also contemplated, and those are also within scope of the present invention. 
     The person skilled in the art will appreciate that for markers with two alleles present in the population being studied (such as SNPs), and wherein one allele is found in increased frequency in a group of individuals with a trait or disease in the population, compared with controls, the other allele of the marker will be found in decreased frequency in the group of individuals with the trait or disease, compared with controls. In such a case, one allele of the marker (the one found in increased frequency in individuals with the trait or disease) will be the at-risk allele, while the other allele will be a protective allele. 
     A genetic variant associated with a disease or a trait (e.g. CAD or MI) can be used alone to predict the risk of the disease for a given genotype. For a biallelic marker, such as a SNP, there are 3 possible genotypes: homozygote for the at risk variant, heterozygote, and non carrier of the at risk variant. Risk associated with variants at multiple loci can be used to estimate overall risk. For multiple SNP variants, there are k possible genotypes k=3 n ×2 p ; where n is the number autosomal loci and p the number of gonosomal (sex chromosomal) loci. Overall risk assessment calculations usually assume that the relative risks of different genetic variants multiply, i.e. the overall risk (e.g., RR or OR) associated with a particular genotype combination is the product of the risk values for the genotype at each locus. If the risk presented is the relative risk for a person, or a specific genotype for a person, compared to a reference population with matched gender and ethnicity, then the combined risk—is the product of the locus specific risk values—and which also corresponds to an overall risk estimate compared with the population. If the risk for a person is based on a comparison to non-carriers of the at risk allele, then the combined risk corresponds to an estimate that compares the person with a given combination of genotypes at all loci to a group of individuals who do not carry risk variants at any of those loci. The group of non-carriers of any at risk variant has the lowest estimated risk and has a combined risk, compared with itself (i.e., non-carriers) of 1.0, but has an overall risk, compare with the population, of less than 1.0. It should be noted that the group of non-carriers can potentially be very small, especially for large number of loci, and in that case, its relevance is correspondingly small. 
     The multiplicative model is a parsimonious model that usually fits the data of complex traits reasonably well. Deviations from multiplicity have been rarely described in the context of common variants for common diseases, and if reported are usually only suggestive since very large sample sizes are usually required to be able to demonstrate statistical interactions between loci. 
     By way of an example, let us consider a total of eight variants that have been described to associate with prostate cancer (Gudmundsson, J., et al.,  Nat Genet  39:631-7 (2007), Gudmundsson, J., et al.,  Nat Genet  39:977-83 (2007); Yeager, M., et al,  Nat Genet  39:645-49 (2007), Amundadottir, L., et al.,  Nat Genet  38:652-8 (2006); Haiman, C. A., et al.,  Nat Genet  39:638-44 (2007)). Seven of these loci are on autosomes, and the remaining locus is on chromosome X. The total number of theoretical genotypic combinations is then 3 7 ×2 1 =4374. Some of those genotypic classes are very rare, but are still possible, and should be considered for overall risk assessment. It is likely that the multiplicative model applied in the case of multiple genetic variant will also be valid in conjugation with non-genetic risk variants assuming that the genetic variant does not clearly correlate with the “environmental” factor. In other words, genetic and non-genetic at-risk variants can be assessed under the multiplicative model to estimate combined risk, assuming that the non-genetic and genetic risk factors do not interact. 
     Using the same quantitative approach, the combined or overall risk associated with a plurality of variants associated with CAD and MI may be assessed. In certain such embodiments, the markers described herein are assessed together with at least one marker in linkage disequilibrium with the CDKN2A and/or CDKN2A genes, such as rs10811650, rs10116277, rs1333040, rs10738607, rs4977574, rs6475608, D9S1870, rs2383207, rs1333045, rs1333046, rs10757278 or rs1333048. In a preferred embodiment, the markers described herein are assessed in combination with rs10757278. 
     Linkage Disequilibrium 
     The natural phenomenon of recombination, which occurs on average once for each chromosomal pair during each meiotic event, represents one way in which nature provides variations in sequence (and biological function by consequence). It has been discovered that recombination does not occur randomly in the genome; rather, there are large variations in the frequency of recombination rates, resulting in small regions of high recombination frequency (also called recombination hotspots) and larger regions of low recombination frequency, which are commonly referred to as Linkage Disequilibrium (LD) blocks (Myers, S. et al.,  Biochem Soc Trans  34:526-530 (2006); Jeffreys, A. J., et al.,  Nature Genet  29:217-222 (2001); May, C. A., et al.,  Nature Genet  31:272-275 (2002)). 
     Linkage Disequilibrium (LD) refers to a non-random assortment of two genetic elements. For example, if a particular genetic element (e.g., “alleles” of a polymorphic marker) occurs in a population at a frequency of 0.50 (50%) and another occurs at a frequency of 0.50 (50%), then the predicted occurrence of a person&#39;s having both elements is 0.25 (25%), assuming a random distribution of the elements. However, if it is discovered that the two elements occur together at a frequency higher than 0.25, then the elements are said to be in linkage disequilibrium since they tend to be inherited together at a higher rate than what their independent allele frequencies would predict. Roughly speaking, LD is generally correlated with the frequency of recombination events between the two elements. Allele frequencies can be determined in a population by genotyping individuals in a population and determining the occurrence of each allele in the population. For populations of diploids, e.g., human populations, individuals will typically have two alleles for each genetic element (e.g., a marker or gene). 
     Many different measures have been proposed for assessing the strength of linkage disequilibrium (LD). Most capture the strength of association between pairs of biallelic sites. Two important pairwise measures of LD are r 2  (sometimes denoted Δ 2 ) and |D′|. Both measures range from 0 (no disequilibrium) to 1 (‘complete’ disequilibrium), but their interpretation is slightly different. |D′| is defined in such a way that it is equal to 1 if just two or three of the possible haplotypes are present, and it is &lt;1 if all four possible haplotypes are present. So, a value of |D′| that is &lt;1 indicates that historical recombination may have occurred between two sites (recurrent mutation can also cause |D′| to be &lt;1, but for single nucleotide polymorphisms (SNPs) this is usually regarded as being less likely than recombination). The measure r 2  represents the statistical correlation between two sites, and takes the value of 1 if only two haplotypes are present. 
     The r 2  measure is arguably the most relevant measure for association mapping, because there is a simple inverse relationship between r 2  and the sample size required to detect association between susceptibility loci and SNPs. These measures are defined for pairs of sites, but for some applications a determination of how strong LD is across an entire region that contains many polymorphic sites might be desirable (e.g., testing whether the strength of LD differs significantly among loci or across populations, or whether there is more or less LD in a region than predicted under a particular model). Measuring LD across a region is not straightforward, but one approach is to use the measure r, which was developed in population genetics. Roughly speaking, r measures how much recombination would be required under a particular population model to generate the LD that is seen in the data. This type of method can potentially also provide a statistically rigorous approach to the problem of determining whether LD data provide evidence for the presence of recombination hotspots. For the methods described herein, a significant r 2  value can be at least 0.1 such as at least 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9, 0.91, 0.92, 0.93, 0.94, 0.95, 0.96, 0.97, 0.98, or at least 0.99. In one preferred embodiment, the significant r 2  value can be at least 0.2. Alternatively, linkage disequilibrium as described herein, refers to linkage disequilibrium characterized by values of |D′| of at least 0.2, such as 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.85, 0.9, 0.95, 0.96, 0.97, 0.98, or at least 0.99. Thus, linkage disequilibrium represents a correlation between alleles of distinct markers. It is measured by correlation coefficient or |D′| (r 2  up to 1.0 and |D′| up to 1.0). In certain embodiments, linkage disequilibrium is defined in terms of values for both the r 2  and |D′| measures. In one such embodiment, a significant linkage disequilibrium is defined as r 2 &gt;0.1 and |D′|&gt;0.8. In another embodiment, a significant linkage disequilibrium is defined as r 2 &gt;0.2 and |D′|&gt;0.9. Other combinations and permutations of values of r 2  and |D′| for determining linkage disequilibrium are also contemplated, and are also within the scope of the invention. Linkage disequilibrium can be determined in a single human population, as defined herein, or it can be determined in a collection of samples comprising individuals from more than one human population. In one embodiment of the invention, LD is determined in a sample from one or more of the HapMap populations (caucasian, african, japanese, chinese), as defined (http://www.hapmap.org). In one such embodiment, LD is determined in the Caucasian CEU population of the HapMap samples. In another embodiment, LD is determined in the African YRI population. In yet another embodiment, LD is determined in samples from the Icelandic population. 
     If all polymorphisms in the genome were independent at the population level (i.e., no LD), then every single one of them would need to be investigated in association studies, to assess all the different polymorphic states. However, due to linkage disequilibrium between polymorphisms, tightly linked polymorphisms are strongly correlated, which reduces the number of polymorphisms that need to be investigated in an association study to observe a significant association. Another consequence of LD is that many polymorphisms may give an association signal due to the fact that these polymorphisms are strongly correlated. 
     Genomic LD maps have been generated across the genome, and such LD maps have been proposed to serve as framework for mapping disease-genes (Risch, N. &amp; Merkiangas, K,  Science  273:1516-1517 (1996); Maniatis, N., et al.,  Proc Natl Acad Sci USA  99:2228-2233 (2002); Reich, D E et al,  Nature  411:199-204 (2001)). 
     It is now established that many portions of the human genome can be broken into series of discrete haplotype blocks containing a few common haplotypes; for these blocks, linkage disequilibrium data provides little evidence indicating recombination (see, e.g., Wall., J. D. and Pritchard, J. K.,  Nature Reviews Genetics  4:587-597 (2003); Daly, M. et al.,  Nature Genet.  29:229-232 (2001); Gabriel, S. B. et al.,  Science  296:2225-2229 (2002); Patil, N. et al.,  Science  294:1719-1723 (2001); Dawson, E. et al.,  Nature  418:544-548 (2002); Phillips, M. S. et al.,  Nature Genet.  33:382-387 (2003)). 
     There are two main methods for defining these haplotype blocks: blocks can be defined as regions of DNA that have limited haplotype diversity (see, e.g., Daly, M. et al.,  Nature Genet.  29:229-232 (2001); Patil, N. et al.,  Science  294:1719-1723 (2001); Dawson, E. et al.,  Nature  418:544-548 (2002); Zhang, K. et al.,  Proc. Natl. Acad. Sci. USA  99:7335-7339 (2002)), or as regions between transition zones having extensive historical recombination, identified using linkage disequilibrium (see, e.g., Gabriel, S. B. et al.,  Science  296:2225-2229 (2002); Phillips, M. S. et al.,  Nature Genet.  33:382-387 (2003); Wang, N. et al.,  Am. J. Hum. Genet.  71:1227-1234 (2002); Stumpf, M. P., and Goldstein, D. B.,  Curr. Biol.  13:1-8 (2003)). More recently, a fine-scale map of recombination rates and corresponding hotspots across the human genome has been generated (Myers, S., et al.,  Science  310:321-32324 (2005); Myers, S. et al.,  Biochem Soc Trans  34:526530 (2006)). The map reveals the enormous variation in recombination across the genome, with recombination rates as high as 10-60 cM/Mb in hotspots, while closer to 0 in intervening regions, which thus represent regions of limited haplotype diversity and high LD. The map can therefore be used to define haplotype blocks/LD blocks as regions flanked by recombination hotspots. As used herein, the terms “haplotype block” or “LD block” includes blocks defined by any of the above described characteristics, or other alternative methods used by the person skilled in the art to define such regions. 
     Haplotype blocks (LD blocks) can be used to map associations between phenotype and haplotype status, using single markers or haplotypes comprising a plurality of markers. The main haplotypes can be identified in each haplotype block, and then a set of “tagging” SNPs or markers (the smallest set of SNPs or markers needed to distinguish among the haplotypes) can then be identified. These tagging SNPs or markers can then be used in assessment of samples from groups of individuals, in order to identify association between phenotype and haplotype. If desired, neighboring haplotype blocks can be assessed concurrently, as there may also exist linkage disequilibrium among the haplotype blocks. 
     It has thus become apparent that for any given observed association to a polymorphic marker in the genome, it is likely that additional markers in the genome also show association. This is a natural consequence of the uneven distribution of LD across the genome, as observed by the large variation in recombination rates. The markers used to detect association thus in a sense represent “tags” for a genomic region (i.e., a haplotype block or LD block) that is associating with a given disease or trait, and as such are useful for use in the methods and kits of the present invention. One or more causative (functional) variants or mutations may reside within the region found to be associating to the disease or trait. Such variants may confer a higher relative risk (RR) or odds ratio (OR) than observed for the tagging markers used to detect the association. The present invention thus refers to the markers used for detecting association to the disease, as described herein, as well as markers in linkage disequilibrium with the markers. Thus, in certain embodiments of the invention, markers that are in LD with the markers and/or haplotypes of the invention, as described herein, may be used as surrogate markers. The surrogate markers have in one embodiment relative risk (RR) and/or odds ratio (OR) values smaller than for the markers or haplotypes initially found to be associating with the disease, as described herein. In other embodiments, the surrogate markers have RR or OR values greater than those initially determined for the markers initially found to be associating with the disease, as described herein. An example of such an embodiment would be a rare, or relatively rare (such as &lt;10% allelic population frequency) variant in LD with a more common variant (&gt;10% population frequency) initially found to be associating with the disease, such as the variants described herein. Identifying and using such markers for detecting the association discovered by the inventors as described herein can be performed by routine methods well known to the person skilled in the art, and are therefore within the scope of the present invention. 
     Determination of Haplotype Frequency 
     The frequencies of haplotypes in patient and control groups can be estimated using an expectation-maximization algorithm (Dempster A. et al.,  J. R. Stat. Soc. B,  39:1-38 (1977)). An implementation of this algorithm that can handle missing genotypes and uncertainty with the phase can be used. Under the null hypothesis, the patients and the controls are assumed to have identical frequencies. Using a likelihood approach, an alternative hypothesis is tested, where a candidate at-risk-haplotype, which can include the markers described herein, is allowed to have a higher frequency in patients than controls, while the ratios of the frequencies of other haplotypes are assumed to be the same in both groups. Likelihoods are maximized separately under both hypotheses and a corresponding 1-df likelihood ratio statistic is used to evaluate the statistical significance. 
     To look for at-risk and protective markers and haplotypes within a linkage region, for example, association of all possible combinations of genotyped markers is studied, provided those markers span a practical region. The combined patient and control groups can be randomly divided into two sets, equal in size to the original group of patients and controls. The marker and haplotype analysis is then repeated and the most significant p-value registered is determined. This randomization scheme can be repeated, for example, over 100 times to construct an empirical distribution of p-values. In a preferred embodiment, a p-value of &lt;0.05 is indicative of an significant marker and/or haplotype association. 
     Haplotype Analysis 
     One general approach to haplotype analysis involves using likelihood-based inference applied to NEsted MOdels (Gretarsdottir S., et al.,  Nat. Genet.  35:131-38 (2003)). The method is implemented in the program NEMO, which allows for many polymorphic markers, SNPs and microsatellites. The method and software are specifically designed for case-control studies where the purpose is to identify haplotype groups that confer different risks. It is also a tool for studying LD structures. In NEMO, maximum likelihood estimates, likelihood ratios and p-values are calculated directly, with the aid of the EM algorithm, for the observed data treating it as a missing-data problem. 
     Even though likelihood ratio tests based on likelihoods computed directly for the observed data, which have captured the information loss due to uncertainty in phase and missing genotypes, can be relied on to give valid p-values, it would still be of interest to know how much information had been lost due to the information being incomplete. The information measure for haplotype analysis is described in Nicolae and Kong (Technical Report 537, Department of Statistics, University of Statistics, University of Chicago;  Biometrics,  60(2):368-75 (2004)) as a natural extension of information measures defined for linkage analysis, and is implemented in NEMO. 
     For single marker association to a disease, the Fisher exact test can be used to calculate two-sided p-values for each individual allele. Usually, all p-values are presented unadjusted for multiple comparisons unless specifically indicated. The presented frequencies (for microsatellites, SNPs and haplotypes) are allelic frequencies as opposed to carrier frequencies. To minimize any bias due the relatedness of the patients who were recruited as families for the linkage analysis, first and second-degree relatives can be eliminated from the patient list. Furthermore, the test can be repeated for association correcting for any remaining relatedness among the patients, by extending a variance adjustment procedure described in Risch, N. &amp; Teng, J. ( Genome Res.,  8:1273-1288 (1998)), DNA pooling (ibid) for sibships so that it can be applied to general familial relationships, and present both adjusted and unadjusted p-values for comparison. The differences are in general very small as expected. To assess the significance of single-marker association corrected for multiple testing we can carry out a randomization test using the same genotype data. Cohorts of patients and controls can be randomized and the association analysis redone multiple times (e.g., up to 500,000 times) and the p-value is the fraction of replications that produced a p-value for some marker allele that is lower than or equal to the p-value we observed using the original patient and control cohorts. Alternatively, a test of association is done in one or several additional case-control cohorts in replication analyses. For tests of single markers, a replication sample analysis only needs to fulfill nominal statistical significance of P&lt;0.05 (two-sided testing; P&lt;0.1 may in fact be more appropriate since a single predefined effect of a single marker is being tested). If many markers are tested in a replication effort, a correction for the number of markers tested in the replication analysis is performed. Alternatively, the results of replication in several case-control cohorts can be combined to provide an overall assessment of the underlying effect, and this may be the most appropriate way of testing the validity of the initially discovered association signal. Deficiencies in individual case-control comparisons, for example due to recruitment bias or population can be neutralized by combined analysis of several case-control studies. The most common method for performing such analysis is the Mantel Haenszel model, which allows different population frequencies for alleles, haplotypes and genotypes but assumes a common relative risk (Mantel, N. &amp; Haenszel, W.,  J Natl Cancer Inst  22:719 (1959)). 
     For both single-marker and haplotype analyses, relative risk (RR) and the population attributable risk (PAR) can be calculated assuming a multiplicative model (haplotype relative risk model) (Terwilliger, J. D. &amp; Ott,  J., Hum. Hered.  42:337-46 (1992) and Falk, C. T. &amp; Rubinstein, P,  Ann. Hum. Genet.  51 (Pt 3):227-33 (1987)), i.e., that the risks of the two alleles/haplotypes a person carries multiply. For example, if RR is the risk of A relative to a, then the risk of a person homozygote AA will be RR times that of a heterozygote Aa and RR 2  times that of a homozygote aa. The multiplicative model has a nice property that simplifies analysis and computations—haplotypes are independent, i.e., in Hardy-Weinberg equilibrium, within the affected population as well as within the control population. As a consequence, haplotype counts of the affected and controls each have multinomial distributions, but with different haplotype frequencies under the alternative hypothesis. Specifically, for two haplotypes, h i  and h j , risk(h i )/risk(h j )=(f i /p i )/(f j /p j ), where f and p denote, respectively, frequencies in the affected population and in the control population. While there is some power loss if the true model is not multiplicative, the loss tends to be mild except for extreme cases. Most importantly, p-values are always valid since they are computed with respect to null hypothesis. 
     Linkage Disequilibrium Using NEMO 
     LD between pairs of markers can be calculated using the standard definition of D′ and r 2  (Lewontin, R.,  Genetics  49:49-67 (1964); Hill, W. G. &amp; Robertson, A.  Theor. Appl. Genet.  22:226-231 (1968)). Using NEMO, frequencies of the two marker allele combinations are estimated by maximum likelihood and deviation from linkage equilibrium is evaluated by a likelihood ratio test. The definitions of D′ and r 2  are extended to include microsatellites by averaging over the values for all possible allele combination of the two markers weighted by the marginal allele probabilities. When plotting all marker combination to elucidate the LD structure in a particular region, we plot D′ in the upper left corner and the p-value in the lower right corner. In the LD plots the markers can be plotted equidistant rather than according to their physical location, if desired. 
     Risk Assessment and Diagnostics 
     Within any given population, there is an absolute risk of developing a disease or trait, defined as the chance of a person developing the specific disease or trait over a specified time-period. For example, a woman&#39;s lifetime absolute risk of breast cancer is one in nine. That is to say, one woman in every nine will develop breast cancer at some point in their lives. Risk is typically measured by looking at very large numbers of people, rather than at a particular individual. Risk is often presented in terms of Absolute Risk (AR) and Relative Risk (RR). Relative Risk is used to compare risks associating with two variants or the risks of two different groups of people. For example, it can be used to compare a group of people with a certain genotype with another group having a different genotype. For a disease, a relative risk of 2 means that one group has twice the chance of developing a disease as the other group. The Risk presented is usually the relative risk for a person, or a specific genotype of a person, compared to the population with matched gender and ethnicity. Risks of two individuals of the same gender and ethnicity could be compared in a simple manner. For example, if, compared to the population, the first individual has relative risk 1.5 and the second has relative risk 0.5, then the risk of the first individual compared to the second individual is 1.5/0.5=3. 
     In certain embodiments, marker and haplotype analysis involves defining a candidate susceptibility region or locus based on “haplotype blocks” (also called “LD blocks”). It is now established that many portions of the human genome can be broken into series of discrete haplotype blocks containing a few common haplotypes; for these blocks, linkage disequilibrium data provides little evidence indicating recombination (see, e.g., Wall., J. D. and Pritchard, J. K.,  Nature Reviews Genetics  4:587-597 (2003); Daly, M. et al.,  Nature Genet.  29:229-232 (2001); Gabriel, S. B. et al.,  Science  296:2225-2229 (2002); Patil, N. et al.,  Science  294:1719-1723 (2001); Dawson, E. et al.,  Nature  418:544-548 (2002); Phillips, M. S. et al.,  Nature Genet.  33:382-387 (2003)). 
     There are two main methods for defining these haplotype blocks: blocks can be defined as regions of DNA that have limited haplotype diversity (see, e.g., Daly, M. et al.,  Nature Genet.  29:229-232 (2001); Patil, N. et al.,  Science  294:1719-1723 (2001); Dawson, E. et al.,  Nature  418:544-548 (2002); Zhang, K. et al.,  Proc. Natl. Acad. Sci. USA  99:7335-7339 (2002)), or as regions between transition zones having extensive historical recombination, identified using linkage disequilibrium (see, e.g., Gabriel, S. B. et al.,  Science  296:2225-2229 (2002); Phillips, M. S. et al.,  Nature Genet.  33:382-387 (2003); Wang, N. et al.,  Am. J. Hum. Genet.  71:1227-1234 (2002); Stumpf, M. P., and Goldstein, D. B.,  Curr. Biol.  13:1-8 (2003)). As used herein, the terms “haplotype block” or “LD block” includes blocks defined by either characteristic. 
     Representative methods for identification of haplotype blocks are set forth, for example, in U.S. Published Patent Application Nos. 20030099964, 20030170665, 20040023237 and 20040146870. Haplotype blocks can be used readily to map associations between phenotype and haplotype status. The main haplotypes can be identified in each haplotype block, and then a set of “tagging” SNPs or markers (the smallest set of SNPs or markers needed to distinguish among the haplotypes) can then be identified. These tagging SNPs or markers can then be used in assessment of samples from groups of individuals, in order to identify association between phenotype and haplotype. If desired, neighboring haplotype blocks can be assessed concurrently, as there may also exist linkage disequilibrium among the haplotype blocks. 
     As described herein, certain markers and haplotypes comprising such markers are found to be useful for risk assessment of cardiovascular disease, including coronary artery disease and myocardial infarction. Risk assessment can involve the use of the markers and variants for diagnosing a susceptibility to cardiovascular disease, including coronary artery disease and myocardial infarction. Particular alleles of polymorphic markers and haplotypes are found more frequently in individuals with cardiovascular disease, including coronary artery disease and myocardial infarction than in individuals without diagnosis of cardiovascular disease, including coronary artery disease and myocardial infarction. Therefore, these marker alleles and haplotypes have predictive value for detecting cardiovascular disease, including coronary artery disease and myocardial infarction, or a susceptibility to coronary artery disease and myocardial infarction, in an individual. Tagging markers within haplotype blocks or LD blocks comprising at-risk markers, such as the markers of the present invention, can be used as surrogates for other markers within the haplotype block or LD block. Markers with values of r 2  equal to 1 are perfect surrogates for the at-risk variants, i.e. genotypes for one marker perfectly predicts genotypes for the other. Markers with smaller values of r 2  than 1 can also be surrogates for the at-risk variant, or alternatively represent variants with relative risk values as high or possibly even higher than the at-risk variant. The at-risk variant identified may therefore not be the functional variant itself, but is in this instance in linkage disequilibrium with the true functional variant. The present invention encompasses the assessment of such surrogate markers for the markers as disclosed herein. Such markers are annotated, mapped and listed in public databases, as well known to the skilled person, or can alternatively be readily identified by sequencing the region or a part of the region identified by the markers of the present invention in a group of individuals, and identify polymorphisms in the resulting group of sequences. As a consequence, the person skilled in the art can readily and without undue experimentation genotype surrogate markers in linkage disequilibrium with the markers and/or haplotypes as described herein. The tagging or surrogate markers in LD with the at-risk variants detected also have predictive value for detecting association to CAD and/or MI, or a susceptibility to CAD and/or MI, in an individual. These tagging or surrogate markers that are in LD with the markers of the present invention can also include other markers that distinguish among haplotypes in associated genomic regions, as these similarly have predictive value for detecting susceptibility to CAD and MI. 
     The present invention can in certain embodiments be practiced by assessing a sample comprising genomic DNA from an individual for the presence of variants described herein to be associated with the cardiovascular diseases CAD and MI. Such assessment includes steps of detecting the presence or absence of at least one allele of at least one polymorphic marker, using methods well known to the skilled person and further described herein, and based on the outcome of such assessment, determine whether the individual from whom the sample is derived is at increased or decreased risk (increased or decreased susceptibility) of CAD and/or MI. Alternatively, the invention can be practiced utilizing a dataset comprising information about the genotype status of at least one polymorphic marker described herein to be associated with CAD and/or MI (or markers in linkage disequilibrium with at least one marker shown herein to be associated with CAD and/or MI). In other words, a dataset containing information about such genetic status, for example in the form of genotype counts at a certain polymorphic marker, or a plurality of markers (e.g., an indication of the presence or absence of certain at-risk alleles), or actual genotypes for one or more markers, can be queried for the presence or absence of certain at-risk alleles at certain polymorphic markers shown by the present inventors to be associated with CAD and/or MI. A positive result for a variant (e.g., marker allele) associated with CAD and/or MI, as shown herein, is indicative of the individual from which the dataset is derived is at increased susceptibility (increased risk) of CAD and/or MI. 
     In certain embodiments of the invention, a polymorphic marker is correlated to CAD and/or MI by referencing genotype data for the polymorphic marker to a look-up table that comprises correlations between at least one allele of the polymorphism and CAD and/or MI. In some embodiments, the table comprises a correlation for one polymorphism. In other embodiments, the table comprises a correlation for a plurality of polymorphisms. In both scenarios, by referencing to a look-up table that gives an indication of a correlation between a marker and CAD and/or MI, a risk for CAD and/or MI, or a susceptibility to CAD and/or MI, can be identified in the individual from whom the sample is derived. In some embodiments, the correlation is reported as a statistical measure. The statistical measure may be reported as a risk measure, such as a relative risk (RR), an absolute risk (AR) or an odds ratio (OR). 
     The markers and haplotypes of the invention, e.g., the markers presented in Table 4, may be useful for risk assessment and diagnostic purposes for coronary artery disease and myocardial infarction, either alone or in combination. Thus, even in the cases where the increase in risk by individual markers is relatively modest, i.e. on the order of 10-30%, the association may have significant implications. Thus, relatively common variants may have significant contribution to the overall risk (Population Attributable Risk is high), or combination of markers can be used to define groups of individual who, based on the combined risk of the markers, is at significant combined risk of developing CAD and/or MI. Thus, in one embodiment of the invention, a plurality of variants (markers and/or haplotypes) is used for overall risk assessment. In such embodiments, the genotype status of a plurality of markers and/or haplotypes is determined in an individual, and the status of the individual compared with the population frequency of the associated variants, or the frequency of the variants in clinically healthy subjects, such as age-matched and sex-matched subjects. Methods known in the art, such as multivariate analyses or joint risk analyses, may subsequently be used to determine the overall risk conferred based on the genotype status at the multiple loci. Assessment of risk based on such analysis may subsequently be used in the methods and kits of the invention, as described herein. 
     As described in the above, the haplotype block structure of the human genome has the effect that a large number of variants (markers and/or haplotypes) in linkage disequilibrium with the variant originally associated with a disease or trait may be used as surrogate markers for assessing association to the disease or trait. The number of such surrogate markers will depend on factors such as the historical recombination rate in the region, the mutational frequency in the region (i.e., the number of polymorphic sites or markers in the region), and the extent of LD (size of the LD block) in the region. These markers are usually located within the physical boundaries of the LD block or haplotype block in question as defined using the methods described herein, or by other methods known to the person skilled in the art. However, sometimes marker and haplotype association is found to extend beyond the physical boundaries of the haplotype block as defined. Such markers and/or haplotypes may in those cases be also used as surrogate markers and/or haplotypes for the markers and/or haplotypes physically residing within the haplotype block as defined. As a consequence, markers and haplotypes in LD (typically characterized by r 2  greater than 0.1, such as r 2  greater than 0.2, including r 2  greater than 0.3, also including r 2  greater than 0.4) with the markers and haplotypes of the present invention are also within the scope of the invention, even if they are physically located beyond the boundaries of the haplotype block as defined. This includes markers that are described herein (e.g., Table 4), but may also include other markers that are in strong LD (characterized by r 2  greater than 0.1 or 0.2 and/or |D′|&gt;0.8) with one or more of the markers listed in Table 4. 
     For the SNP markers described herein, the opposite allele to the allele found to be in excess in patients (at-risk allele) is found in decreased frequency in coronary artery disease and myocardial infarction. These markers and haplotypes in LD and/or comprising such markers, are thus protective for coronary artery disease and myocardial infarction, i.e. they confer a decreased risk or susceptibility of individuals carrying these markers and/or haplotypes developing coronary artery disease and myocardial infarction. 
     Certain variants of the present invention, including certain haplotypes comprise, in some cases, a combination of various genetic markers, e.g., SNPs and microsatellites. Detecting haplotypes can be accomplished by methods known in the art and/or described herein for detecting sequences at polymorphic sites. Furthermore, correlation between certain haplotypes or sets of markers and disease phenotype can be verified using standard techniques. A representative example of a simple test for correlation would be a Fisher-exact test on a two by two table. 
     In specific embodiments, a marker allele or haplotype associated with coronary artery disease and myocardial infarction (e.g., marker alleles as listed in Table 4) is one in which the marker allele or haplotype is more frequently present in an individual at risk for coronary artery disease and/or myocardial infarction (affected), compared to the frequency of its presence in a healthy individual (control), wherein the presence of the marker allele or haplotype is indicative of coronary artery disease and/or myocardial infarction or a susceptibility to coronary artery disease and/or myocardial infarction. In other embodiments, at-risk markers in linkage disequilibrium with one or more markers found to be associated with coronary artery disease and/or myocardial infarction (e.g., marker alleles as listed in Table 4) are tagging markers that are more frequently present in an individual at risk for coronary artery disease and/or myocardial infarction (affected), compared to the frequency of their presence in a healthy individuals (controls), wherein the presence of the tagging markers is indicative of increased susceptibility to coronary artery disease and/or myocardial infarction. In a further embodiment, at-risk markers alleles (i.e. conferring increased susceptibility) in linkage disequilibrium with one or more markers found to be associated with coronary artery disease and/or myocardial infarction (e.g., marker alleles as listed in Table 4), are markers comprising one or more allele that is more frequently present in an individual at risk for coronary artery disease and/or myocardial infarction, compared to the frequency of their presence in a healthy individual (control), wherein the presence of the markers is indicative of increased susceptibility to coronary artery disease and/or myocardial infarction. 
     Utility of Genetic Testing 
     The person skilled in the art will appreciate and understand that the variants described herein in general do not, by themselves, provide an absolute identification of individuals who will develop coronary artery disease or myocardial infarction. The variants described herein do however indicate increased and/or decreased likelihood that individuals carrying the at-risk or protective variants of the invention will develop CAD or MI, or develop symptoms associated with these diseases. This information is however extremely valuable in itself, as outlined in more detail in the below, as it can be used to, for example, initiate preventive measures at an early stage, perform regular physical and/or mental exams to monitor the progress and/or appearance of symptoms, or to schedule exams at a regular interval to identify early symptoms, so as to be able to apply treatment at an early stage. 
     The knowledge about a genetic variant that confers a risk of developing cardiovascular disease, including coronary artery disease and myocardial infarction, offers the opportunity to apply a genetic test to distinguish between individuals with increased risk of developing the disease (i.e. carriers of the at-risk variant) and those with decreased risk of developing the disease (i.e. carriers of the protective variant). The core values of genetic testing, for individuals belonging to both of the above mentioned groups, are the possibilities of being able to diagnose disease, or a predisposition to disease, at an early stage and provide information to the clinician about prognosis/aggressiveness of disease in order to be able to apply the most appropriate treatment. 
     Individuals with a family history of CAD and/or MI and carriers of at-risk variants may benefit from genetic testing since the knowledge of the presence of a genetic risk factor, or evidence for increased risk of being a carrier of one or more risk factors, may provide increased incentive for implementing a healthier lifestyle (e.g., lose weight, increase exercise, give um smoking, reduce stress, etc.), by avoiding or minimizing known environmental risk factors for these cardiovascular diseases. Genetic testing of patients may furthermore give valuable information about the primary cause of the disease and can aid the clinician in selecting the best treatment options and medication for each individual. 
     The present invention can be thus be used for risk assessment for coronary artery disease and/or myocardial infarction, including diagnosing whether an individual is at risk for developing myocardial infarction and/or coronary artery disease. The polymorphic markers of the present invention can be used alone or in combination, as well as in combination with other factors, including known biomarkers, for risk assessment of an individual for coronary artery disease and/or myocardial infarction. Many factors known to affect the predisposition of individual towards developing risk of developing cardiovascular disease, including coronary artery disease and/or myocardial infarction, are known to the person skilled in the art and can be utilized in such assessment. These include, but are not limited to, age, gender, smoking status, physical activity, waist-to-hip circumference ratio, family history of Cardiovascular Disease (e.g., MI and/or CAD), previously diagnosed cardiovascular disease, obesity, diagnosis of Diabetes mellitus, stress, depression, elevated heart rate, hypertriglyceridemia, low HDL cholesterol, hypertension, elevated blood pressure, cholesterol levels, HDL cholesterol, LDL cholesterol, triglycerides, apolipoprotein AI and B levels, fibrinogen, ferritin, C-reactive protein and leukotriene levels. Methods known in the art can be used for such assessment, including multivariate analyses or logistic regression, as described further herein. 
     Methods 
     Methods for risk management and risk assessment of CAD and MI are described herein and are encompassed by the invention. The invention also encompasses methods of assessing an individual for probability of response to a therapeutic agent for a CAD and/or MI, methods for predicting the effectiveness of a therapeutic agent for CAD and/or MI, nucleic acids, polypeptides and antibodies and computer-implemented functions useful in such methods. Kits for assaying a sample from a subject to detect susceptibility to cardiovascular disease are also encompassed by the invention. 
     Diagnostic and Screening Methods 
     In certain embodiments, the present invention pertains to methods of diagnosing, or aiding in the diagnosis of coronary artery disease (CAD) and/or myocardial infarction (MI) or a susceptibility to CAD and/or MI, by detecting particular alleles at genetic markers that appear more frequently in individuals diagnosed with CAD and MI or individuals who are susceptible to CAD and MI. In a particular embodiment, the invention is a method of diagnosing a susceptibility to CAD and/or MI by detecting at least one allele of at least one polymorphic marker (e.g., the markers described herein). The present invention describes methods whereby detection of particular alleles of particular markers or haplotypes is indicative of a susceptibility to CAD and MI. Such prognostic or predictive assays can also be used to determine prophylactic treatment of a subject prior to the onset of symptoms of cardiovascular disease, including coronary artery disease and myocardial infarction. The present invention pertains in some embodiments to methods of clinical applications of diagnosis, e.g., diagnosis performed by a medical professional. In other embodiments, the invention pertains to methods of diagnosis or determination of a susceptibility performed by a layman. The layman can be the customer of a genotyping service. The layman may also be a genotype service provider, who performs genotype analysis on a DNA sample from an individual, in order to provide service related to genetic risk factors for particular traits or diseases, based on the genotype status of the individual (i.e., the customer). A third party who provides service to individuals can be one who provides a guidance or teaching as to how to relate or interpret genotype information to calculate or estimate genetic risk. In one embodiment, the third party may receive a sample containing genomic DNA from a customer, send the sample, or DNA isolated from the sample, to a genotype service provider, and present the customer with the genotype data and/or an interpretation of the genotype data, such as by calculating disease risk for specific markers. The customer may access his/her genotype information, including results of any risk calculations, via a secure we interface. Alternatively, the customer may receive disease risk information by other means, such as by regular mail. Recent technological advances in genotyping technologies, including high-throughput genotyping of SNP markers, such as Molecular Inversion Probe array technology (e.g., Affymetrix GeneChip), and BeadArray Technologies (e.g., Illumina GoldenGate and Infinium assays) have made it possible for individuals to have their own genome assessed for up to one million SNPs simultaneously, at relatively little cost. The resulting genotype information, made available to the individual can be compared to information from the public literature about disease or trait risk associated with various SNPs. The diagnostic application of disease-associated alleles as described herein, can thus for example be performed by the individual, through analysis of his/her genotype data, by a health professional based on results of a clinical test, or by a third party. In other words, the diagnosis or determination of a susceptibility of genetic risk can be made by health professionals, genetic counselors, third parties providing such service or by the layman, based on information about the genotype status of an individual and knowledge about the risk conferred by particular genetic risk factors (e.g., particular SNPs). In the present context, the term “diagnosing”, “diagnose a susceptibility” and “determine a susceptibility” is meant to refer to any available diagnostic method, including those mentioned above. 
     In certain embodiments, a sample containing genomic DNA from an individual is collected. Such sample can for example be a buccal swab, a saliva sample, a blood sample, or other suitable samples containing genomic DNA, as described further herein. The genomic DNA is then analyzed using any common technique available to the skilled person, such as high-throughput array technologies. Results from such genotyping are stored in a convenient data storage unit, such as a data carrier, including computer databases, data storage disks, or by other convenient data storage means. In certain embodiments, the computer database is an object database, a relational database or a post-relational database. The genotype data is subsequently analyzed for the presence of certain variants known to be susceptibility variants for a particular human conditions, such as the genetic variants described herein. Genotype data can be retrieved from the data storage unit using any convenient data query method. Calculating risk conferred by a particular genotype for the individual is based on comparing the genotype to previously determined risk (expressed as a relative risk (RR) or and odds ratio (OR), for example) for the genotype, for example for an heterozygous carrier of an at-risk variant for a particular disease or trait (such as CAD and/or MI). Risk presented can be the relative risk for a person, or a specific genotype of a person, compared to the population with matched gender and ethnicity. The average population risk can be expressed as a weighted average of the risks of different genotypes, using results from a reference population, and the appropriate calculations to calculate the risk of a genotype group relative to the population can then be performed. Alternatively, the risk for an individual is based on a comparison of particular genotypes, for example heterozygous carriers of an at-risk allele of a marker compared with non-carriers of the at-risk allele. Using the population average may in certain embodiments be more convenient, since it provides a measure which is easy to interpret for the user, i.e. a measure that gives the risk for the individual, based on his/her genotype, compared with the average in the population. 
     Overall risk for multiple risk variants can be performed using standard methodology. For example, assuming a multiplicative model, i.e. assuming that the risk of individual risk variants multiply to establish the overall effect, allows for a straight-forward calculation of the overall risk for multiple markers. 
     In addition, in certain other embodiments, the present invention pertains to methods of diagnosing, or aiding in the diagnosis of, a decreased susceptibility to cardiovascular disease, in particular CAD and/or MI, by detecting particular genetic marker alleles or haplotypes that appear less frequently in individuals diagnosed with CAD and/or MI than in individual not diagnosed with these diseases, or in the general population. 
     As described and exemplified herein, particular marker alleles or haplotypes (e.g. the markers as set forth in Table 4 and markers in linkage disequilibrium therewith) are associated with risk of coronary artery disease and/or myocardial infarction. In one embodiment, the marker allele or haplotype is one that confers a significant risk or susceptibility to coronary artery disease and/or myocardial infarction. In another embodiment, the invention relates to a method of diagnosing a susceptibility to CAD and/or MI in a human individual, the method comprising determining the presence or absence of at least one allele of at least one polymorphic marker in a nucleic acid sample obtained from the individual, wherein the at least one polymorphic marker is selected from the group consisting of the polymorphic markers listed in Table 4, and markers in linkage disequilibrium therewith. In another embodiment, the invention pertains to methods of diagnosing a susceptibility to CAD and/or MI in a human individual, by screening for at least one marker allele or haplotype as listed in Table 4 or markers in linkage disequilibrium therewith. In another embodiment, the marker allele or haplotype is more frequently present in a subject having, or who is susceptible to, CAD and/or MI (affected), as compared to the frequency of its presence in a healthy subject (control, such as population controls). In certain embodiments, the significance of association of the at least one marker allele or haplotype is characterized by a p value &lt;0.05. In other embodiments, the significance of association is characterized by smaller p-values, such as &lt;0.01, &lt;0.001, &lt;0.0001, &lt;0.00001, &lt;0.000001, &lt;0.0000001, &lt;0.00000001 or &lt;0.000000001. 
     In these embodiments, the presence of the at least one marker allele or haplotype is indicative of a susceptibility to coronary artery disease and/or myocardial infarction. These diagnostic methods involve detecting the presence or absence of at least one marker allele or haplotype that is associated with coronary artery disease and/or myocardial infarction. The haplotypes described herein include combinations of alleles at various genetic markers (e.g., SNPs, microsatellites). The detection of the particular genetic marker alleles that make up the particular haplotypes can be performed by a variety of methods described herein and/or known in the art. For example, genetic markers can be detected at the nucleic acid level (e.g., by direct nucleotide sequencing or by other means known to the skilled in the art) or at the amino acid level if the genetic marker affects the coding sequence of a protein encoded by a coronary artery disease and/or myocardial infarction-associated nucleic acid (e.g., by protein sequencing or by immunoassays using antibodies that recognize such a protein). The marker alleles or haplotypes of the present invention correspond to fragments of a genomic DNA sequence associated with coronary artery disease and/or myocardial infarction. Such fragments encompass the DNA sequence of the polymorphic marker or haplotype in question, but may also include DNA segments in strong LD (linkage disequilibrium) with the marker or haplotype. 
     In one embodiment, diagnosis of a susceptibility to CAD and/or MI can be accomplished using hybridization methods, including, but not limited to, hybridization to a microarray, Southern analysis, Northern analysis, and/or in situ hybridizations (see Current Protocols in Molecular Biology, Ausubel, F. et al., eds., John Wiley &amp; Sons, including all supplements). The presence of a specific marker allele can be indicated by sequence-specific hybridization of a nucleic acid probe specific for the particular allele. The presence of more than one specific marker allele or a specific haplotype can be indicated by using several sequence-specific nucleic acid probes, each being specific for a particular allele. In one embodiment, a haplotype can be indicated by a single nucleic acid probe that is specific for the specific haplotype (i.e., hybridizes specifically to a DNA strand comprising the specific marker alleles characteristic of the haplotype). A sequence-specific probe can be directed to hybridize to genomic DNA, RNA, or cDNA. A “nucleic acid probe”, as used herein, can be a DNA probe or an RNA probe that hybridizes to a complementary sequence. One of skill in the art would know how to design such a probe so that sequence specific hybridization will occur only if a particular allele is present in a genomic sequence from a test sample. Other methods of using hybridization probes in allele-specific detection methods include methods of single base extension of nucleotide probes flanking a single base polymorphic sites. Such methods are well known to the skilled artisan. 
     To determine a susceptibility or diagnose a susceptibility, a hybridization sample is formed by contacting the test sample containing an nucleic acid associated with CAD and/or MI, such as a genomic DNA sample, with at least one nucleic acid probe. A non-limiting example of a probe for detecting mRNA or genomic DNA is a labeled nucleic acid probe that is capable of hybridizing to mRNA or genomic DNA sequences described herein. The nucleic acid probe can be, for example, a full-length nucleic acid molecule, or a portion thereof, such as an oligonucleotide of at least 15, 30, 50, 100, 250 or 500 nucleotides in length that is sufficient to specifically hybridize under stringent conditions to appropriate mRNA or genomic DNA. For example, the nucleic acid probe can comprise all or a portion of the nucleotide sequence of any one of SEQ ID NO:1-172, as set forth herein, or the probe can be the complementary sequence of such a sequence. Other suitable probes for use in the diagnostic assays of the invention are described herein. Hybridization can be performed by methods well known to the person skilled in the art (see, e.g., Current Protocols in Molecular Biology, Ausubel, F. et al., eds., John Wiley &amp; Sons, including all supplements). In one embodiment, hybridization refers to specific hybridization, i.e., hybridization with no mismatches (exact hybridization). In one embodiment, the hybridization conditions for specific hybridization are high stringency. 
     Specific hybridization, if present, is detected using standard methods. If specific hybridization occurs between the nucleic acid probe and the nucleic acid in the test sample, then the sample contains the allele that is complementary to the nucleotide that is present in the nucleic acid probe. The process can be repeated for any markers of the present invention, or markers that make up a haplotype of the present invention, or multiple probes can be used concurrently to detect more than one marker alleles at a time. It is also possible to design a single probe containing more than one marker alleles of a particular haplotype (e.g., a probe containing alleles complementary to 2, 3, 4, 5 or all of the markers that make up a particular haplotype). Detection of the particular markers of the haplotype in the sample is indicative that the source of the sample has the particular haplotype (e.g., a haplotype) and therefore is susceptible to CAD and/or MI. 
     In one preferred embodiment, a method utilizing a detection oligonucleotide probe comprising a fluorescent moiety or group at its 3′ terminus and a quencher at its 5′ terminus, and an enhancer oligonucleotide, is employed, as described by Kutyavin et al. ( Nucleic Acid Res.  34:e128 (2006)). The fluorescent moiety can be Gig Harbor Green or Yakima Yellow, or other suitable fluorescent moieties. The detection probe is designed to hybridize to a short nucleotide sequence that includes the SNP polymorphism to be detected. Preferably, the SNP is anywhere from the terminal residue to −6 residues from the 3′ end of the detection probe. The enhancer is a short oligonucleotide probe which hybridizes to the DNA template 3′ relative to the detection probe. The probes are designed such that a single nucleotide gap exists between the detection probe and the enhancer nucleotide probe when both are bound to the template. The gap creates a synthetic abasic site that is recognized by an endonuclease, such as Endonuclease IV. The enzyme cleaves the dye off the fully complementary detection probe, but cannot cleave a detection probe containing a mismatch. Thus, by measuring the fluorescence of the released fluorescent moiety, assessment of the presence of a particular allele defined by nucleotide sequence of the detection probe can be performed. 
     The detection probe can be of any suitable size, although preferably the probe is relatively short. In one embodiment, the probe is from 5-100 nucleotides in length. In another embodiment, the probe is from 10-50 nucleotides in length, and in another embodiment, the probe is from 12-30 nucleotides in length. Other lengths of the probe are possible and within scope of the skill of the average person skilled in the art. 
     In a preferred embodiment, the DNA template containing the SNP polymorphism is amplified by Polymerase Chain Reaction (PCR) prior to detection. In such an embodiment, the amplified DNA serves as the template for the detection probe and the enhancer probe. 
     Certain embodiments of the detection probe, the enhancer probe, and/or the primers used for amplification of the template by PCR include the use of modified bases, including modified A and modified G. The use of modified bases can be useful for adjusting the melting temperature of the nucleotide molecule (probe and/or primer) to the template DNA, for example for increasing the melting temperature in regions containing a low percentage of G or C bases, in which modified A with the capability of forming three hydrogen bonds to its complementary T can be used, or for decreasing the melting temperature in regions containing a high percentage of G or C bases, for example by using modified G bases that form only two hydrogen bonds to their complementary C base in a double stranded DNA molecule. In a preferred embodiment, modified bases are used in the design of the detection nucleotide probe. Any modified base known to the skilled person can be selected in these methods, and the selection of suitable bases is well within the scope of the skilled person based on the teachings herein and known bases available from commercial sources as known to the skilled person. 
     In another hybridization method, Northern analysis (see Current Protocols in Molecular Biology, Ausubel, F. et al., eds., John Wiley &amp; Sons, supra) is used to identify the presence of a polymorphism associated with CAD and/or MI. For Northern analysis, a test sample of RNA is obtained from the subject by appropriate means. As described herein, specific hybridization of a nucleic acid probe to RNA from the subject is indicative of a particular allele complementary to the probe. For representative examples of use of nucleic acid probes, see, for example, U.S. Pat. Nos. 5,288,611 and 4,851,330. 
     Additionally, or alternatively, a peptide nucleic acid (PNA) probe can be used in addition to, or instead of, a nucleic acid probe in the hybridization methods described herein. A PNA is a DNA mimic having a peptide-like, inorganic backbone, such as N-(2-aminoethyl)glycine units, with an organic base (A, G, C, T or U) attached to the glycine nitrogen via a methylene carbonyl linker (see, for example, Nielsen, P., et al.,  Bioconjug. Chem.  5:3-7 (1994)). The PNA probe can be designed to specifically hybridize to a molecule in a sample suspected of containing one or more of the marker alleles or haplotypes that are associated with CAD and/or MI. Hybridization of the PNA probe is thus diagnostic for a susceptibility of CAD and/or MI. 
     In one embodiment of the invention, a test sample containing genomic DNA obtained from the subject is collected and the polymerase chain reaction (PCR) is used to amplify a fragment comprising one or more markers or haplotypes of the present invention. As described herein, identification of a particular marker allele or haplotype associated with CAD and/MI, can be accomplished using a variety of methods (e.g., sequence analysis, analysis by restriction digestion, specific hybridization, single stranded conformation polymorphism assays (SSCP), electrophoretic analysis, etc.). In another embodiment, diagnosis is accomplished by expression analysis using quantitative PCR (kinetic thermal cycling). This technique can, for example, utilize commercially available technologies, such as TaqMan® (Applied Biosystems, Foster City, Calif.). The technique can assess the presence of an alteration in the expression or composition of a polypeptide or splicing variant(s) that is encoded by a nucleic acid associated with CAD and/or MI, as described herein. Further, the expression of the variant(s) can be quantified as physically or functionally different. 
     In another embodiment of the methods of the invention, analysis by restriction digestion can be used to detect a particular allele if the allele results in the creation or elimination of a restriction site relative to a reference sequence. Restriction fragment length polymorphism (RFLP) analysis can be conducted, e.g., as described in Current Protocols in Molecular Biology, supra. The digestion pattern of the relevant DNA fragment indicates the presence or absence of the particular allele in the sample. 
     Sequence analysis can also be used to detect specific alleles or haplotypes associated with CAD and/or MI (e.g. the polymorphic markers of Table 4 and markers in linkage disequilibrium therewith). Therefore, in one embodiment, determination of the presence or absence of a particular marker alleles or haplotypes comprises sequence analysis of a test sample of DNA or RNA obtained from a subject or individual. PCR or other appropriate methods can be used to amplify a portion of a nucleic acid template, and the presence of a specific allele can then be detected directly by sequencing the polymorphic site (or multiple polymorphic sites in a haplotype) of the genomic DNA in the sample. 
     In another embodiment, arrays of oligonucleotide probes that are complementary to target nucleic acid sequence segments from a subject, can be used to identify polymorphisms in a nucleic acid associated with CAD and/or MI (e.g. the polymorphic markers of Table 4 and markers in linkage disequilibrium therewith). For example, an oligonucleotide array can be used. Oligonucleotide arrays typically comprise a plurality of different oligonucleotide probes that are coupled to a surface of a substrate in different known locations. These arrays can generally be produced using mechanical synthesis methods or light directed synthesis methods that incorporate a combination of photolithographic methods and solid phase oligonucleotide synthesis methods, or by other methods known to the person skilled in the art (see, e.g., Fodor, S. et al.,  Science,  251:767-773 (1991); Pirrung et al., U.S. Pat. No. 5,143,854 (see also published PCT Application No. WO 90/15070); and Fodor. S. et al., published PCT Application No. WO 92/10092 and U.S. Pat. No. 5,424,186, the entire teachings of each of which are incorporated by reference herein). Techniques for the synthesis of these arrays using mechanical synthesis methods are described in, e.g., U.S. Pat. No. 5,384,261; the entire teachings of which are incorporated by reference herein. In another example, linear arrays can be utilized. Additional descriptions of use of oligonucleotide arrays for detection of polymorphisms can be found, for example, in U.S. Pat. Nos. 5,858,659 and 5,837,832, the entire teachings of both of which are incorporated by reference herein. 
     Other methods of nucleic acid analysis that are available to those skilled in the art can be used to detect a particular allele at a polymorphic site associated with CAD and/or MI (e.g. the polymorphic markers of Table 4 and markers in linkage disequilibrium therewith). Representative methods include, for example, direct manual sequencing (Church and Gilbert,  Proc. Natl. Acad. Sci. USA,  81: 1991-1995 (1988); Sanger, F., et al.,  Proc. Natl. Acad. Sci. USA,  74:5463-5467 (1977); Beavis, et al., U.S. Pat. No. 5,288,644); automated fluorescent sequencing; single-stranded conformation polymorphism assays (SSCP); clamped denaturing gel electrophoresis (CDGE); denaturing gradient gel electrophoresis (DGGE) (Sheffield, V., et al.,  Proc. Natl. Acad. Sci. USA,  86:232-236 (1989)), mobility shift analysis (Orita, M., et al.,  Proc. Natl. Acad. Sci. USA,  86:2766-2770 (1989)), restriction enzyme analysis (Flavell, R., et al.,  Cell,  15:25-41 (1978); Geever, R., et al.,  Proc. Natl. Acad. Sci. USA,  78:5081-5085 (1981)); heteroduplex analysis; chemical mismatch cleavage (CMC) (Cotton, R., et al.,  Proc. Natl. Acad. Sci. USA,  85:4397-4401 (1985)); RNase protection assays (Myers, R., et al.,  Science,  230:1242-1246 (1985); use of polypeptides that recognize nucleotide mismatches, such as  E. coli  mutS protein; and allele-specific PCR. 
     In another embodiment of the invention, diagnosis of CAD and/or MI or a susceptibility to CAD and/or MI can be made by examining expression and/or composition of a polypeptide encoded by a nucleic acid associated with these diseases, in those instances where the genetic marker(s) or haplotype(s) of the present invention result in a change in the composition or expression of the polypeptide. Thus, diagnosis or determination of a susceptibility can be made by examining expression and/or composition of one of these polypeptides, or another polypeptide encoded by a nucleic acid associated with CAD and/or MI, in those instances where the genetic marker or haplotype of the present invention results in a change in the composition or expression of the polypeptide. The haplotypes and markers of the present invention that show association to CAD and MI may play a role through their effect on one or more of these nearby genes (e.g., the Lp(a) gene). Possible mechanisms affecting these genes include, e.g., effects on transcription, effects on RNA splicing, alterations in relative amounts of alternative splice forms of mRNA, effects on RNA stability, effects on transport from the nucleus to cytoplasm, and effects on the efficiency and accuracy of translation. 
     Thus, in another embodiment, the variants (markers or haplotypes) of the invention showing association to CAD and/or MI affect the expression of a nearby gene, such as the Lp(a) gene. It is well known that regulatory element affecting gene expression may be located far away, even as far as tenths or hundreds of kilobases away, from the promoter region of a gene. By assaying for the presence or absence of at least one allele of at least one polymorphic marker of the present invention, it is thus possible to assess the expression level of such nearby genes. It is thus contemplated that the detection of the markers or haplotypes of the present invention can be used for assessing expression of genes associated with (in LD with) the associated markers. 
     A variety of methods can be used for detecting protein expression levels, including enzyme linked immunosorbent assays (ELISA), Western blots, immunoprecipitations and immunofluorescence. A test sample from a subject is assessed for the presence of an alteration in the expression and/or an alteration in composition of the polypeptide encoded by a nucleic acid associated with CAD and/or MI. An alteration in expression of a polypeptide encoded by a nucleic acid associated with CAD and/or MI can be, for example, an alteration in the quantitative polypeptide expression (i.e., the amount of polypeptide produced). An alteration in the composition of a polypeptide encoded by a nucleic acid associated with CAD and/or MI is an alteration in the qualitative polypeptide expression (e.g., expression of a mutant polypeptide or of a different splicing variant). In one embodiment, diagnosis of a susceptibility to CAD and/or MI is made by detecting a particular splicing variant encoded by a nucleic acid associated with these diseases, or a particular pattern of splicing variants. 
     Both such alterations (quantitative and qualitative) can also be present. An “alteration” in the polypeptide expression or composition, as used herein, refers to an alteration in expression or composition in a test sample, as compared to the expression or composition of the polypeptide in a control sample. A control sample is a sample that corresponds to the test sample (e.g., is from the same type of cells), and is from a subject who is not affected by, and/or who does not have a susceptibility to, CAD and/or MI. In one embodiment, the control sample is from a subject that does not possess a marker allele or haplotype associated with CAD and/or MI, as described herein. Similarly, the presence of one or more different splicing variants in the test sample, or the presence of significantly different amounts of different splicing variants in the test sample, as compared with the control sample, can be indicative of a susceptibility to CAD and/or MI. An alteration in the expression or composition of the polypeptide in the test sample, as compared with the control sample, can be indicative of a specific allele in the instance where the allele alters a splice site relative to the reference in the control sample. Various means of examining expression or composition of a polypeptide encoded by a nucleic acid are known to the person skilled in the art and can be used, including spectroscopy, colorimetry, electrophoresis, isoelectric focusing, and immunoassays (e.g., David et al., U.S. Pat. No. 4,376,110) such as immunoblotting (see, e.g., Current Protocols in Molecular Biology, particularly chapter 10, supra). 
     For example, in one embodiment, an antibody (e.g., an antibody with a detectable label) that is capable of binding to a polypeptide encoded by a nucleic acid associated with CAD and/or MI can be used. Antibodies can be polyclonal or monoclonal. An intact antibody, or a fragment thereof (e.g., Fv, Fab, Fab′, F(ab′) 2 ) can be used. The term “labeled”, with regard to the probe or antibody, is intended to encompass direct labeling of the probe or antibody by coupling (i.e., physically linking) a detectable substance to the probe or antibody, as well as indirect labeling of the probe or antibody by reactivity with another reagent that is directly labeled. Examples of indirect labeling include detection of a primary antibody using a labeled secondary antibody (e.g., a fluorescently-labeled secondary antibody) and end-labeling of a DNA probe with biotin such that it can be detected with fluorescently-labeled streptavidin. 
     In one embodiment of this method, the level or amount of polypeptide encoded by a nucleic acid associated with CAD and/or MI in a test sample is compared with the level or amount of the polypeptide in a control sample. A level or amount of the polypeptide in the test sample that is higher or lower than the level or amount of the polypeptide in the control sample, such that the difference is statistically significant, is indicative of an alteration in the expression of the polypeptide encoded by the nucleic acid, and is diagnostic for a particular allele or haplotype responsible for causing the difference in expression. Alternatively, the composition of the polypeptide in a test sample is compared with the composition of the polypeptide in a control sample. In another embodiment, both the level or amount and the composition of the polypeptide can be assessed in the test sample and in the control sample. 
     In another embodiment, the diagnosis of a susceptibility to CAD and/or MI is made by detecting at least one marker or haplotypes of the present invention (e.g., associated alleles of the markers listed in Table 4, and markers in linkage disequilibrium therewith), in combination with an additional protein-based, RNA-based or DNA-based assay. 
     Kits 
     Kits useful in the methods of the invention comprise components useful in any of the methods described herein, including for example, primers for nucleic acid amplification, hybridization probes, restriction enzymes (e.g., for RFLP analysis), allele-specific oligonucleotides, antibodies that bind to an altered polypeptide encoded by a nucleic acid of the invention as described herein (e.g., a genomic segment comprising at least one polymorphic marker and/or haplotype of the present invention) or to a non-altered (native) polypeptide encoded by a nucleic acid of the invention as described herein, means for amplification of a nucleic acid templates, means for analyzing the nucleic acid sequence of a nucleic acids, means for analyzing the amino acid sequence of a polypeptide encoded by a nucleic acid associated with CAD and/or MI, etc. The kits can for example include necessary buffers, nucleic acid primers for amplifying nucleic acids of the invention (e.g., a nucleic acid segment comprising one or more of the polymorphic markers as described herein), and reagents for allele-specific detection of the fragments amplified using such primers and necessary enzymes (e.g., DNA polymerase). Additionally, kits can provide reagents for assays to be used in combination with the methods of the present invention, e.g., reagents for use with other diagnostic assays for CAD and/or MI. 
     In one embodiment, the invention is a kit for assaying a sample from a subject to detect a susceptibility to coronary artery disease and/or myocardial infarction in a subject, wherein the kit comprises reagents necessary for selectively detecting at least one allele of at least one polymorphism of the present invention in the genome of the individual. In a particular embodiment, the reagents comprise at least one contiguous oligonucleotide that hybridizes to a fragment of the genome of the individual comprising at least one polymorphism of the present invention. In another embodiment, the reagents comprise at least one pair of oligonucleotides that hybridize to opposite strands of a genomic segment obtained from a subject, wherein each oligonucleotide primer pair is designed to selectively amplify a fragment of the genome of the individual that includes one polymorphism, wherein the polymorphism is selected from the group consisting of the polymorphisms as defined in and polymorphic markers in linkage disequilibrium therewith. In yet another embodiment the fragment is at least 20 base pairs in size. Such oligonucleotides or nucleic acids (e.g., oligonucleotide primers) can be designed using portions of the nucleic acids flanking polymorphisms (e.g., SNPs or microsatellites) that are indicative of coronary artery disease and myocardial infarction. In another embodiment, the kit comprises one or more labeled nucleic acids capable of detecting one or more specific polymorphic markers or haplotypes associated with coronary artery disease and/or myocardial infarction, and reagents for detection of the label. Suitable labels include, e.g., a radioisotope, a fluorescent label, an enzyme label, an enzyme co-factor label, a magnetic label, a spin label, an epitope label. 
     In particular embodiments, the polymorphic marker or haplotype to be detected by the reagents of the kit comprises one or more markers, two or more markers, three or more markers, four or more markers or five or more markers selected from the group consisting of the markers in Table 3. In another embodiment, the marker or haplotype to be detected comprises the markers listed in Table 4, and markers in linkage disequilibrium therewith. In another embodiment, the marker or haplotype to be detected is selected from marker rs11751605, rs6076623, rs1412444, rs2163612, rs1029396, rs2243547, rs12534186, rs12134779 and rs7158073. In another embodiment, the marker or haplotype to be detected is selected from marker rs11751605, rs6076623, rs1412444, rs2163612 and rs1029396. In another embodiment, the marker or haplotype to be detected is marker rs11751605. In such embodiments, the presence of the marker or haplotype is indicative of a susceptibility (increased susceptibility or decreased susceptibility) to cardiovascular disease, including coronary artery disease and myocardial infarction. 
     In one preferred embodiment, the kit for detecting the markers of the invention comprises a detection oligonucleotide probe, that hybridizes to a segment of template DNA containing a SNP polymorphisms to be detected, an enhancer oligonucleotide probe and an endonuclease. As explained in the above, the detection oligonucleotide probe comprises a fluorescent moiety or group at its 3′ terminus and a quencher at its 5′ terminus, and an enhancer oligonucleotide, is employed, as described by Kutyavin et al. ( Nucleic Acid Res.  34:e128 (2006)). The fluorescent moiety can be Gig Harbor Green or Yakima Yellow, or other suitable fluorescent moieties. The detection probe is designed to hybridize to a short nucleotide sequence that includes the SNP polymorphism to be detected. Preferably, the SNP is anywhere from the terminal residue to −6 residues from the 3′ end of the detection probe. The enhancer is a short oligonucleotide probe which hybridizes to the DNA template 3′ relative to the detection probe. The probes are designed such that a single nucleotide gap exists between the detection probe and the enhancer nucleotide probe when both are bound to the template. The gap creates a synthetic abasic site that is recognized by an endonuclease, such as Endonuclease IV. The enzyme cleaves the dye off the fully complementary detection probe, but cannot cleave a detection probe containing a mismatch. Thus, by measuring the fluorescence of the released fluorescent moiety, assessment of the presence of a particular allele defined by nucleotide sequence of the detection probe can be performed. 
     The detection probe can be of any suitable size, although preferably the probe is relatively short. In one embodiment, the probe is from 5-100 nucleotides in length. In another embodiment, the probe is from 10-50 nucleotides in length, and in another embodiment, the probe is from 12-30 nucleotides in length. Other lengths of the probe are possible and within scope of the skill of the average person skilled in the art. 
     In a preferred embodiment, the DNA template containing the SNP polymorphism is amplified by Polymerase Chain Reaction (PCR) prior to detection, and primers for such amplification are included in the reagent kit. In such an embodiment, the amplified DNA serves as the template for the detection probe and the enhancer probe. 
     In one embodiment, the DNA template is amplified by means of Whole Genome Amplification (WGA) methods, prior to assessment for the presence of specific polymorphic markers as described herein. Standard methods well known to the skilled person for performing WGA may be utilized, and are within scope of the invention. In one such embodiment, reagents for performing WGA are included in the reagent kit. 
     Certain embodiments of the detection probe, the enhancer probe, and/or the primers used for amplification of the template by PCR include the use of modified bases, including modified A and modified G. The use of modified bases can be useful for adjusting the melting temperature of the nucleotide molecule (probe and/or primer) to the template DNA, for example for increasing the melting temperature in regions containing a low percentage of G or C bases, in which modified A with the capability of forming three hydrogen bonds to its complementary T can be used, or for decreasing the melting temperature in regions containing a high percentage of G or C bases, for example by using modified G bases that form only two hydrogen bonds to their complementary C base in a double stranded DNA molecule. In a preferred embodiment, modified bases are used in the design of the detection nucleotide probe. Any modified base known to the skilled person can be selected in these methods, and the selection of suitable bases is well within the scope of the skilled person based on the teachings herein and known bases available from commercial sources as known to the skilled person. 
     In one of such embodiments, the presence of the marker or haplotype is indicative of a susceptibility (increased susceptibility or decreased susceptibility) to CAD and/or MI. In another embodiment, the presence of the marker or haplotype is indicative of response to a therapeutic agent for a cardiovascular disease, such as CAD and MI. In another embodiment, the presence of the marker or haplotype is indicative of prognosis of MI and/or CAD. In yet another embodiment, the presence of the marker or haplotype is indicative of progress of treatment of CAD and/or MI. Such treatment may include intervention by surgery, medication or by other means (e.g., lifestyle changes). 
     In a further aspect of the present invention, a pharmaceutical pack (kit) is provided, the pack comprising a therapeutic agent and a set of instructions for administration of the therapeutic agent to humans diagnostically tested for one or more variants of the present invention, as disclosed herein. The therapeutic agent can be a small molecule drug, an antibody, a peptide, an antisense or RNAi molecule, or other therapeutic molecules. In one embodiment, an individual identified as a carrier of at least one variant of the present invention is instructed to take a prescribed dose of the therapeutic agent. In one such embodiment, an individual identified as a homozygous carrier of at least one variant of the present invention is instructed to take a prescribed dose of the therapeutic agent. In another embodiment, an individual identified as a non-carrier of at least one variant of the present invention is instructed to take a prescribed dose of the therapeutic agent. 
     In certain embodiments, the kit further comprises a set of instructions for using the reagents comprising the kit. 
     Therapeutic Agents 
     Variants of the present invention (e.g., the markers and/or haplotypes of the invention as described herein, e.g., the markers listed in Table 3 and 4) can be used to identify novel therapeutic targets for coronary artery disease or myocardial infarction, or other cardiovascular disease. For example, genes containing, or in linkage disequilibrium with, variants (markers and/or haplotypes) associated with cardiovascular disease, or their products (e.g., Lipoprotein(a) gene and its gene product), as well as genes or their products that are directly or indirectly regulated by or interact with these genes or their products, can be targeted for the development of therapeutic agents to treat cardiovascular disease, or prevent or delay onset of symptoms associated with cardiovascular disease. Therapeutic agents may comprise one or more of, for example, small non-protein and non-nucleic acid molecules, proteins, peptides, protein fragments, nucleic acids (DNA, RNA), PNA (peptide nucleic acids), or their derivatives or mimetics which can modulate the function and/or levels of the target genes or their gene products. 
     The nucleic acids and/or variants of the invention, or nucleic acids comprising their complementary sequence, may be used as antisense constructs to control gene expression in cells, tissues or organs. The methodology associated with antisense techniques is well known to the skilled artisan, and is described and reviewed in  AntisenseDrug Technology: Principles, Strategies, and Applications , Crooke, ed., Marcel Dekker Inc., New York (2001). In general, antisense nucleic acid molecules are designed to be complementary to a region of mRNA expressed by a gene, so that the antisense molecule hybridizes to the mRNA, thus blocking translation of the mRNA into protein. Several classes of antisense oligonucleotide are known to those skilled in the art, including cleavers and blockers. The former bind to target RNA sites, activate intracellular nucleases (e.g., RnaseH or Rnase L), that cleave the target RNA. Blockers bind to target RNA, inhibit protein translation by steric hindrance of the ribosomes. Examples of blockers include nucleic acids, morpholino compounds, locked nucleic acids and methylphosphonates (Thompson,  Drug Discovery Today,  7:912-917 (2002)). Antisense oligonucleotides are useful directly as therapeutic agents, and are also useful for determining and validating gene function, for example by gene knock-out or gene knock-down experiments. Antisense technology is further described in Lavery et al.,  Curr. Opin. Drug Discov. Devel.  6:561-569 (2003), Stephens et al.,  Curr. Opin. Mol. Ther.  5:118-122 (2003), Kurreck,  Eur. J. Biochem.  270:1628-44 (2003), Dias et al.,  Mol. Cancer Ter.  1:347-55 (2002), Chen,  Methods Mol. Med.  75:621-636 (2003), Wang et al.,  Curr. Cancer Drug Targets  1:177-96 (2001), and Bennett,  Antisense Nucleic Acid Drug. Dev.  12:215-24 (2002) 
     The variants described herein can be used for the selection and design of antisense reagents that are specific for particular variants. Using information about the variants described herein, antisense oligonucleotides or other antisense molecules that specifically target mRNA molecules that contain one or more variants of the invention can be designed. In this manner, expression of mRNA molecules that contain one or more variant of the present invention (markers and/or haplotypes) can be inhibited or blocked. In one embodiment, the antisense molecules are designed to specifically bind a particular allelic form (i.e., one or several variants (alleles and/or haplotypes)) of the target nucleic acid, thereby inhibiting translation of a product originating from this specific allele or haplotype, but which do not bind other or alternate variants at the specific polymorphic sites of the target nucleic acid molecule. 
     As antisense molecules can be used to inactivate mRNA so as to inhibit gene expression, and thus protein expression, the molecules can be used to treat a disease or disorder, such as a cardiovascular disease. The methodology can involve cleavage by means of ribozymes containing nucleotide sequences complementary to one or more regions in the mRNA that attenuate the ability of the mRNA to be translated. Such mRNA regions include, for example, protein-coding regions, in particular protein-coding regions corresponding to catalytic activity, substrate and/or ligand binding sites, or other functional domains of a protein. 
     The phenomenon of RNA interference (RNAi) has been actively studied for the last decade, since its original discovery in  C. elegans  (Fire et al.,  Nature  391:806-11 (1998)), and in recent years its potential use in treatment of human disease has been actively pursued (reviewed in Kim &amp; Rossi,  Nature Rev. Genet.  8:173-204 (2007)). RNA interference (RNAi), also called gene silencing, is based on using double-stranded RNA molecules (dsRNA) to turn off specific genes. In the cell, cytoplasmic double-stranded RNA molecules (dsRNA) are processed by cellular complexes into small interfering RNA (siRNA). The siRNA guide the targeting of a protein-RNA complex to specific sites on a target mRNA, leading to cleavage of the mRNA (Thompson,  Drug Discovery Today,  7:912-917 (2002)). The siRNA molecules are typically about 20, 21, 22 or 23 nucleotides in length. Thus, one aspect of the invention relates to isolated nucleic acid molecules, and the use of those molecules for RNA interference, i.e. as small interfering RNA molecules (siRNA). In one embodiment, the isolated nucleic acid molecules are 18-26 nucleotides in length, preferably 19-25 nucleotides in length, more preferably 20-24 nucleotides in length, and more preferably 21, 22 or 23 nucleotides in length. 
     Another pathway for RNAi-mediated gene silencing originates in endogenously encoded primary microRNA (pri-miRNA) transcripts, which are processed in the cell to generate precursor miRNA (pre-miRNA). These miRNA molecules are exported from the nucleus to the cytoplasm, where they undergo processing to generate mature miRNA molecules (miRNA), which direct translational inhibition by recognizing target sites in the 3′ untranslated regions of mRNAs, and subsequent mRNA degradation by processing P-bodies (reviewed in Kim &amp; Rossi,  Nature Rev. Genet.  8:173-204 (2007)). 
     Clinical applications of RNAi include the incorporation of synthetic siRNA duplexes, which preferably are approximately 20-23 nucleotides in size, and preferably have 3′ overlaps of 2 nucleotides. Knockdown of gene expression is established by sequence-specific design for the target mRNA. Several commercial sites for optimal design and synthesis of such molecules are known to those skilled in the art. 
     Other applications provide longer siRNA molecules (typically 25-30 nucleotides in length, preferably about 27 nucleotides), as well as small hairpin RNAs (shRNAs; typically about 29 nucleotides in length). The latter are naturally expressed, as described in Amarzguioui et al. ( FEBS Lett.  579:5974-81 (2005)). Chemically synthetic siRNAs and shRNAs are substrates for in vivo processing, and in some cases provide more potent gene-silencing than shorter designs (Kim et al.,  Nature Biotechnol.  23:222-226 (2005); Siolas et al.,  Nature Biotechnol.  23:227-231 (2005)). In general siRNAs provide for transient silencing of gene expression, because their intracellular concentration is diluted by subsequent cell divisions. By contrast, expressed shRNAs mediate long-term, stable knockdown of target transcripts, for as long as transcription of the shRNA takes place (Marques et al.,  Nature Biotechnol.  23:559-565 (2006); Brummelkamp et al.,  Science  296: 550-553 (2002)). 
     Since RNAi molecules, including siRNA, miRNA and shRNA, act in a sequence-dependent manner, the variants of the present invention (e.g., the markers and haplotypes set forth in Tables 3, 4 and 5) can be used to design RNAi reagents that recognize specific nucleic acid molecules comprising specific alleles and/or haplotypes (e.g., the alleles and/or haplotypes of the present invention), while not recognizing nucleic acid molecules comprising other alleles or haplotypes. These RNAi reagents can thus recognize and destroy the target nucleic acid molecules. As with antisense reagents, RNAi reagents can be useful as therapeutic agents (i.e., for turning off disease-associated genes or disease-associated gene variants), but may also be useful for characterizing and validating gene function (e.g., by gene knock-out or gene knock-down experiments). 
     Delivery of RNAi may be performed by a range of methodologies known to those skilled in the art. Methods utilizing non-viral delivery include cholesterol, stable nucleic acid-lipid particle (SNALP), heavy-chain antibody fragment (Fab), aptamers and nanoparticles. Viral delivery methods include use of lentivirus, adenovirus and adeno-associated virus. The siRNA molecules are in some embodiments chemically modified to increase their stability. This can include modifications at the 2′ position of the ribose, including 2′-O-methylpurines and 2′-fluoropyrimidines, which provide resistance to Rnase activity. Other chemical modifications are possible and known to those skilled in the art. 
     The following references provide a further summary of RNAi, and possibilities for targeting specific genes using RNAi: Kim &amp; Rossi,  Nat. Rev. Genet.  8:173-184 (2007), Chen &amp; Rajewsky,  Nat. Rev. Genet.  8: 93-103 (2007), Reynolds, et al.,  Nat. Biotechnol.  22:326-330 (2004), Chi et al.,  Proc. Natl. Acad. Sci. USA  100:6343-6346 (2003), Vickers et al.,  J. Biol. Chem.  278:7108-7118 (2003), Agami,  Curr. Opin. Chem. Biol.  6:829-834 (2002), Lavery, et al.,  Curr. Opin. Drug Discov. Devel.  6:561-569 (2003), Shi,  Trends Genet.  19:9-12 (2003), Shuey et al.,  Drug Discov. Today  7:1040-46 (2002), McManus et al.,  Nat. Rev. Genet.  3:737-747 (2002), Xia et al.,  Nat. Biotechnol.  20:1006-10 (2002), Plasterk et al.,  curr. Opin. Genet. Dev.  10:562-7 (2000), Bosher et al.,  Nat. Cell Biol.  2:E31-6 (2000), and Hunter,  Curr. Biol.  9:R440-442 (1999). 
     A genetic defect leading to increased predisposition or risk for development of a cardiovascular disease, or a defect causing the disease, may be corrected permanently by administering to a subject carrying the defect a nucleic acid fragment that incorporates a repair sequence that supplies the normal/wild-type nucleotide(s) at the site of the genetic defect. Such site-specific repair sequence may concompass an RNA/DNA oligonucleotide that operates to promote endogenous repair of a subject&#39;s genomic DNA. The administration of the repair sequence may be performed by an appropriate vehicle, such as a complex with polyethelenimine, encapsulated in anionic liposomes, a viral vector such as an adenovirus vector, or other pharmaceutical compositions suitable for promoting intracellular uptake of the adminstered nucleic acid. The genetic defect may then be overcome, since the chimeric oligonucleotides induce the incorporation of the normal sequence into the genome of the subject, leading to expression of the normal/wild-type gene product. The replacement is propagated, thus rendering a permanent repair and alleviation of the symptoms associated with the disease or condition. 
     The present invention provides methods for identifying compounds or agents that can be used to treat cardiovascular diseases, such as coronary artery disease and myocardial infarction. Thus, the variants of the invention are useful as targets for the identification and/or development of therapeutic agents. In certain embodiments, such methods include assaying the ability of an agent or compound to modulate the activity and/or expression of a nucleic acid that includes at least one of the variants (markers and/or haplotypes) of the present invention, or the encoded product of the nucleic acid (e.g., the Lp(a) gene). This in turn can be used to identify agents or compounds that inhibit or alter the undesired activity or expression of the encoded nucleic acid product. Assays for performing such experiments can be performed in cell-based systems or in cell-free systems, as known to the skilled person. Cell-based systems include cells naturally expressing the nucleic acid molecules of interest, or recombinant cells that have been genetically modified so as to express a certain desired nucleic acid molecule. 
     Variant gene expression in a patient can be assessed by expression of a variant-containing nucleic acid sequence (for example, a gene containing at least one variant of the present invention, which can be transcribed into RNA containing the at least one variant, and in turn translated into protein), or by altered expression of a normal/wild-type nucleic acid sequence due to variants affecting the level or pattern of expression of the normal transcripts, for example variants in the regulatory or control region of the gene. Assays for gene expression include direct nucleic acid assays (mRNA), assays for expressed protein levels, or assays of collateral compounds involved in a pathway, for example a signal pathway. Furthermore, the expression of genes that are up- or down-regulated in response to the signal pathway can also be assayed. One embodiment includes operably linking a reporter gene, such as luciferase, to the regulatory region of the gene(s) of interest. 
     Modulators of gene expression can in one embodiment be identified when a cell is contacted with a candidate compound or agent, and the expression of mRNA is determined. The expression level of mRNA in the presence of the candidate compound or agent is compared to the expression level in the absence of the compound or agent. Based on this comparison, candidate compounds or agents for treating cardiovascular disease can be identified as those modulating the gene expression of the variant gene. When expression of mRNA or the encoded protein is statistically significantly greater in the presence of the candidate compound or agent than in its absence, then the candidate compound or agent is identified as a stimulator or up-regulator of expression of the nucleic acid. When nucleic acid expression or protein level is statistically significantly less in the presence of the candidate compound or agent than in its absence, then the candidate compound is identified as an inhibitor or down-regulator of the nucleic acid expression. 
     The invention further provides methods of treatment using a compound identified through drug (compound and/or agent) screening as a gene modulator (i.e. stimulator and/or inhibitor of gene expression). 
     Methods of Assessing Probability of Response to Therapeutic Agents and Methods, Methods of Monitoring Treatment Progress and Methods for Treating Cardiovascular Disease 
     As is known in the art, individuals can have differential responses to a particular therapy (e.g., a therapeutic agent or therapeutic method). Pharmacogenomics addresses the issue of how genetic variations (e.g., the variants (markers and/or haplotypes) of the present invention) affect drug response, due to altered drug disposition and/or abnormal or altered action of the drug. Thus, the basis of the differential response may be genetically determined in part. Clinical outcomes due to genetic variations affecting drug response may result in toxicity of the drug in certain individuals (e.g., carriers or non-carriers of the genetic variants of the present invention), or therapeutic failure of the drug. Therefore, the variants of the present invention may determine the manner in which a therapeutic agent and/or method acts on the body, or the way in which the body metabolizes the therapeutic agent. 
     Accordingly, in one embodiment, the presence of a particular allele of a polymorphic marker, or the presence of a haplotype as described herein is indicative of a different response rate to a particular treatment modality for coronary artery disease or myocardial infarction. This means that a patient diagnosed with coronary artery disease or myocardial infarction, or at risk for coronary artery disease or myocardial infarction, and carrying a certain allele at a polymorphic or haplotype of the present invention (e.g., the at-risk alleles and/or haplotypes of the invention) would respond better to, or worse to, a specific therapeutic, drug and/or other therapy used to treating these diseases. Therefore, the presence or absence of the marker allele or haplotype could aid in deciding what treatment is appropriate for the patient. For example, for a newly diagnosed patient, the presence of a marker or haplotype of the present invention may be assessed (e.g., through testing DNA derived from a blood sample or other sample containing genomic DNA, as described herein). If the patient is positive for a marker allele or haplotype at (that is, at least one specific allele of the marker, or haplotype, is present), then the physician recommends one particular therapy (e.g., one particular therapeutic agent or a combination of therapeutic agents), while if the patient is negative for the at least one allele of a marker, or a haplotype, then a different course of therapy may be recommended (which may include recommending that no immediate therapy, other than serial monitoring for progression of the disease, be performed). Thus, the patient&#39;s carrier status could be used to help determine whether a particular treatment modality should be administered. The value lies within the possibilities of being able to diagnose the disease at an early stage and provide information to the clinician about prognosis/aggressiveness of the disease in order to be able to apply the most appropriate treatment. 
     As one example, the application of a genetic test can identify subjects who are at high risk of developing restenosis after coronary stent procedure. While it is know that some treatment methods for coronary artery disease, such as introducing drug-eluting stents and brachytherapy, are associated with decreased risk of in-stent restenosis, the use of these methods are restricted because of number of reasons, including economical reasons. Identification of individuals within the group of those undergoing coronary stent procedure who are carriers of particular genetic risk variants will allow targeting of those individuals that would benefit most from therapy associated with decreased risk of in-stent restenosis. 
     The present invention also relates to methods of monitoring effectiveness of a treatment for coronary artery disease and/or myocardial infarction. This can be done based on the genotype and/or haplotype status of the markers and haplotypes of the present invention, or by monitoring expression of genes that are associated with the variants (markers and haplotypes) of the present invention (e.g., the Lp(a) gene). The risk gene mRNA or the encoded polypeptide can be measured in a tissue sample (e.g., a peripheral blood sample, or a biopsy sample). Expression levels and/or mRNA levels can thus be determined before and during treatment to monitor its effectiveness. Alternatively, or concomitantly, the genotype and/or haplotype status of at least one risk variant for coronary artery disease or myocardial infarction as presented herein is determined before and during treatment to monitor its effectiveness. 
     The treatment modules of coronary artery disease and/or myocardial infarction to which the invention pertains includes, but is not limited to, methods of treatment for coronary artery disease or myocardial infarction or a susceptibility to coronary artery disease or myocardial infarction; methods of phophylaxis therapy for coronary artery disease or myocardial infarction; methods of treatment for acute coronary syndrome (e.g., unstable angina, non-ST-elevation myocardial infarction (NSTEMI) or ST-elevation myocardial infarction (STEMI)); methods for reducing risk of coronary artery disease and/or myocardial infarction; methods for decreasing risk of a second myocardial infarction; methods of treatment for atherosclerosis, such as for patients requiring treatment (e.g., angioplasty, stents, revascularization procedure) to restore blood flow in arteries (e.g., coronary, carotid, and/or femoral arteries); and/or methods for decreasing leukotriene synthesis (e.g., for treatment of coronary artery disease or myocardial infarction). 
     Treatment of coronary artery disease and myocardial infarction (MI) may be categorized as (i) preventive treatment and (ii) disease management. The main goal of the latter is to minimize damage to the heart and prevent further complications. The first line of disease management typically includes one or more of administration of oxygen, aspirin, glyceryl nitrate (nitroglycerin) and analgesia, such as morphine or related drugs. Once diagnosis of MI is made, additional therapy may include beta blockers, anticoagulation agents, including heparin and/or low molecular weigh heparin, and possibly also antiplatelet agents, such as clopidogrel. Secondary prevention, i.e. the management of risk of a recurrent MI, typically includes one or more of the following: Antiplatelet drug therapy, including aspirin and/or clopidogrel, beta blocker therapy, including metoprolol and carvedilol, ACE inhibitor therapy, Statin therapy, Aldosterone antagonist therapy, including eplerenone. Further, non-therapeutic administration of food supplements such as omega-3 fatty acids may be beneficial. 
     New preventive therapy for coronary artery disease and/or myocardial infarction, includes agents that act on the formation and/or rupture of plaques, and also includes phosphodiesterase inhibitors. Such therapeutic agents are useful in the methods of the invention, as described herein. This includes, but is not limited to, agents that target the leukotriene synthesis pathway. The leukotriene synthesis inhibitor can be any agent that inhibits or antagonizes a member of the leukotriene synthesis pathway (e.g., FLAP, 5-LO, LTC4S, LTA4H, and LTB4DH). For example, the leukotriene synthesis inhibitor can be an agent that inhibits or antagonizes FLAP polypeptide activity (e.g., a FLAP inhibitor) and/or FLAP nucleic acid expression (e.g., a FLAP nucleic acid antagonist). In another embodiment, the leukotriene synthesis inhibitor is an agent that inhibits or antagonizes polypeptide activity and/or nucleic acid expression of another member of the leukotriene biosynthetic pathway (e.g., LTC4S, LTA4H) or that increases breakdown of leukotrienes (e.g., LTB4DH). In preferred embodiments, the agent alters activity and/or nucleic acid expression of FLAP, LTA4H or of 5-LO. Preferred agents include those set forth in the Agent Table I herein. In another embodiment, preferred agents can be: 1-((4-chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(2-quinolinylmethoxy)-1H-Indole-2-propanoic acid otherwise known as MK-0591, (R)-(+)-alpha-cyclopentyl-4-(2-quinolinylmethoxy)-Benzeneacetic acid, otherwise known as BAY-x-1005, 3-(3-(1,1-dimethylethylthio-5-(quinoline-2-ylmethoxy)-1-(4-chloromethylphenyl)indole-2-yl)-2,2-dimethylpropionaldehyde oxime-O-2-acetic acid otherwise known as A-81834; or can be zileuton, atreleuton, 6-((3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4yl)phenoxy)methyl)-1-methyl-2(1H)-quinlolinone otherwise known as ZD-2138, 1-((4-chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(2-quinolinylmethoxy)-1H-Indole-2-propanoic acid otherwise known as MK-886, 4-(3-(4-(2-Methyl-imidazol-1-yl)-phenylsulfanyl)-phenyl)-tetrahydro-pyran-4-carboxylic acid amide otherwise known as CJ-13610. Additional agents include those described in Penning et al.,  Med Chem.  2002 45(16):3482-90, Penning,  Curr Pharm Des.  2001, 7(3):163-79 and Penning et al.,  J Med Chem.  2000 43(4):721-35. In another embodiment, the agent alters metabolism or activity of a leukotriene (e.g., LTA4, LTB4, LTC4, LTD4, LTE4, Cys LT1, Cys LT2), such as leukotriene antagonists or antibodies to leukotrienes, as well as agents which alter activity of a leukotriene receptor (e.g., BLT1, BLT2, CysLTR1, and CysLTR2). 
     In other preferred embodiments, the agent alters activity and/or nucleic acid expression of LTA4H. Preferred agents include those set forth in the Agent Table II; but also include the following agents: 1-[2-[4-(phenylmethyl)phenoxy]ethyl]-2-methyl-4-tetrazolylpieridine; 1-[2-[4-(4-oxazolyl)phenoxy)phenoxy]ethyl]pyrrolidine; 3-[methyl[3-[4-(2-thienylmethyl)phenoxy]propyl]amino]propionic acid; methyl 3-[methyl[3-[4-(2-thienylmethyl)phenoxy]propyl]amino]propionate; 3-[methyl[3-[4-(3-thienylmethyl)phenoxy]propyl]amino]propionic acid; methyl-3-[methyl[3-4-(3-thienylmethyl)phenoxy]propyl]amino]propionate; 3-[methyl[3-[4-(4-fluorophenoxy)phenoxy]propyl]amino]propionic acid; 3-[methyl[3-[4-(4-biphenyloxy)phenoxy]propyl]amino]propionic acid; N-[3-[[3-[4-(phenylmethyl)phenoxy]propyl]methylamino]propionyl]benzenesulfonamide; 1-[2-[4-(phenylmethyl)phenoxy]ethyl]-2-methyl-4-(1H-tetrazol-5-yl)piperidine; 1-[2-[4-(phenylmethyl)phenoxy]ethyl]-4-(1H-tetrazol-5-yl)piperidine. In another embodiment, preferred agents can be: ethyl-1-[2-[4-(phenylmethyl)phenoxy]ethyl]-4-piperidine-carboxylate, otherwise known as SC-56938; [4-[5-(3-Phenyl-propyl)thiophen-2-yl]butoxy]acetic acid, otherwise known as RP64966; (R)—S-[[4-(dimethylamino)phenyl]methyl]-N-(3-mercapto-2methyl-1-oxopropyl-L-cycteine, otherwise known as SA6541. In one preferred embodiment, the therapeutic agent is 4-{(S)-2-[4-(4-Chloro-phenoxy)-phenoxymethyl]-pyrrolidin-1-yl}-butyramide, also known as DG-051. 
     The agents for treating or preventing coronary artery disease and/or myocardial infarction can be adminstered alone, or in combination with a statin. Statins include, but are not limited to, the agents rovuvastatin, fluvastatin, atorvastatin, lovastatin (also known as mevolin), simvastatin, pravastatin, pitavastatin, mevastatin, crevastatin, ML-236A, ML-236B, MBV-530A and MB-530B. 
     All agents listed in the above and in Agent Table I and Agent Table II also include their optically pure enantiomers, salts, chemical derivatives, and analogues. 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 AGENT TABLE I 
               
               
                   
               
               
                   
                   
                   
                   
                   
                 Date Patent  
                   
               
               
                   
                   
                   
                   
                   
                 Issued/ 
                   
               
               
                   
                 Product_Name 
                   
                   
                   
                 Application 
                   
               
               
                   
                 (Code) 
                 Structure 
                 Chemical Name 
                 Patent Ref 
                 Published 
                 MOA 
               
               
                   
               
             
            
               
                 Abbott 
                 atreleuton (ABT-761)  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (R)-(+)-N-[3[5-[(4- fluorophenyl)methyl]-2thienyl]- 1 methyl-2-propynyl]-N- hydroxurea 
                 U.S. Pat. No. 5,288,751, U.S. Pat. No. 5,288,743, U.S. Pat. No. 5,616,596  
                 Feb. 22, 1994 Apr. 1, 1997 
                 5-LPO inhibitor 
               
               
                   
               
               
                 Abbott 
                 A-81834 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-(3-(1,1-dimethylethylthio-5- 3-(quinoline-2-ylmethoxy)-1-(4- chloromethylphenyl)indo1e-2-yl) 2,2-dirnethylpropionaldehyde  oxime-0-2-acetic acid 
                 WO9203132, U.S. Pat. No. 5,459,150 
                 Mar. 5, 1992, Oct. 17, 1995 
                 FLAP Inhibitor 
               
               
                   
               
               
                 Abbott 
                 A-86886 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-(3-(1,1-dirnethylethylthlo-5- (pyridin-2-ylmathoxy)-1-(4- chloromethylphenyl)indole-2-yl)- 2,2-dimethylpropionaldehyde oxime-0-2-acetic acid 
                 W052031 32, U.S. Pat. No. 5,459,150 
                 Mar. 5,1992, Oct. 17, 1995 
                 5-LP0 Inhibitor 
               
               
                   
               
               
                 Abbott 
                 A-93178 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
                   
                   
                 FLAP inhibitor 
               
               
                   
               
               
                 AstraZeneca 
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
                 EP 623514 
                 Sep. 11, 1994 
                 9-LPO inhibitor 
               
               
                   
               
               
                 AstraZenaca 
                 ZD2138 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-((3-f1uoro-5- (tetrahydro-4-methoxy-2H- pyran-4yl)phenoxy)methyl) 1-methyl-2(1H)-quinlolinone (alternatively NH can be N-methyl) 
                 EP 466452 
                   
                 5-LPO inhibitor 
               
               
                   
               
               
                 Bayer 
                 BAY-X-1005 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (R)-(+)-alpha-cyclopentyl 4-(2-quinolinylmethoxy)- Benzeneacetic acid 
                 U.S. Pat. No. 4,970,215 EP 344519, DE 19880531 
                   
                 FLAP Inhibitor 
               
               
                   
               
               
                 Merck 
                 MK-0591 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 1-((4-chlorophenyl)methyl)-3- ((1,1-dimethylethyl)thio)alpha, alpha-dimethyl-5-(2-quinolinylmethoxy)-1H-Indole-2-propanoic acid 
                 EP 419049, U.S. Pat. No. 19,890,822 
                   
                 FLAP Inhibitor 
               
               
                   
               
               
                 Merck 
                 MK-866 
                   
                 (3(3-)-4-chlorobenzyl)-3-t-butyl- thio-5-isopropylindol-2-yl]2,2- dimethyl-propionic acid 
                   
                   
                 5-LPO inhibitor 
               
               
                   
               
               
                 Merck 
                 MK-886 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 1-((4- chlorophenyl)methyl)-3- ((1,1dimethylethyl)thio)- alpha, alpha-dimethyl-5-(2-quinolinylmethoxy)-1H- Indole-2-propanoic acid 
                 EP 419049, U.S. Pat. No. 19,890,822 
                   
                 5-LPO inhibitor 
               
               
                   
               
               
                 Pfizer 
                 CJ-13610 
                   
                 4-(3-(4-(2-Methyl-imidazol-1-yl)- phenylsulfanyl)-phenyl)-tetrahydro-pyran-4- carboxylic acid amide 
                   
                   
                 5-LPO inhibitor 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                 AGENT TABLE II 
               
               
                   
               
               
                   
                 Compound 
                   
                   
               
               
                 Target 
                 ID 
                 Chemical Name 
                 Patent/Reference 
               
               
                   
               
             
            
               
                 LTA4H 
                 SC-57461A 
                 3-[methyl[3-[4- 
                 Penning, T.D. et. al. Bioorg Med. 
               
               
                 Inhibitor 
                   
                 (phenylmethyl)phenoxy]- 
                 Chem. Letters (2003), 13, 1137-1139. 
               
               
                   
                   
                 propyl]amino]propionic 
                 ibid, (2002), 12, 3383-3386 
               
               
                   
                   
                 acid 
               
               
                 LTA4H 
                 SC-56938 
                 Ethyl-1-[2-[4- 
                 Penning, T.D. et. al. Bioorg Med. 
               
               
                 Inhibitor 
                   
                 (phenylmethyl)phenoxy]ethyl]- 
                 Chem. Letters (2003), 13, 1137-1139. 
               
               
                   
                   
                 4-piperidine- 
                 ibid, (2002), 12, 3383-3386. 
               
               
                   
                   
                 carboxylate 
                 U.S. Pat. No. 6,506,87 6A1 
               
               
                 LTA4H 
                 RP 64966 
                 [4-[5-(3-Phenyl- 
                 WO9627585 
               
               
                 Inhibitor 
                   
                 propyl)thiophen-2- 
               
               
                   
                   
                 yl]butoxy]acetic acid 
               
               
                 LTA4H 
                 SA 6541 
                 (R)—S-[[4- 
                 WO9809943 
               
               
                 Inhibitor 
                   
                 (dimethylamino)phenyl]methyl]- 
               
               
                   
                   
                 N-(3-mercapto- 
               
               
                   
                   
                 2methyl-1-oxopropyl-L- 
               
               
                   
                   
                 cycteine 
               
               
                 LTA4H 
                 SA-9499/ 
                 (R)-3-(4-Dimethylamino- 
               
               
                 Inhibitor 
                 SA-6541 
                 benzylsulfanyl)-2-((R)-3- 
               
               
                   
                   
                 mercapto-2-methyl- 
               
               
                   
                   
                 propionylamino)-propionic 
               
               
                   
                   
                 acid 
               
               
                 LTB4 
                 Amelubant/ 
                 Carbamic acid,((4-((3-((4- 
                 U.S. Pat. No. 6,576,669 
               
               
                 Receptor 
                 BIIL-284 
                 (1-(4-hydroxyphenyl)-1- 
               
               
                 Antagonist 
                   
                 methylethyl)phenoxy)methyl)phenyl)methoxy)- 
               
               
                   
                   
                 phenyl)iminomethyl)ethyl ester 
               
               
                 LTB4 
                 BIRZ-227 
                 5-Chloro-2-[3-(4- 
                 Journal of Organic Chemistry 
               
               
                 Receptor 
                   
                 methoxy-phenyl)-2- 
                 1998, 63: 2(326-330). 
               
               
                 Antagonist 
                   
                 pyridin-2-yl-pyrrolidin-1- 
               
               
                   
                   
                 yl]-benzooxazole 
               
               
                 LTB4 
                 CP 195543 
                 2-[(3S,4R)-3,4-dihydro-4- 
                 Process: WO 98/11085 1998, priority 
               
               
                 Receptor 
                   
                 hydroxy-3- 
                 US 60/26372 1996; J. 
               
               
                 Antagonist 
                   
                 (phenylmethyl)-2H-1- 
                 Pharamacology and Expert. Therapy, 
               
               
                   
                   
                 benzopyran-7-yl]-4- 
                 1998, 285: 946-54 
               
               
                   
                   
                 (trifluoromethyl)benzoic 
               
               
                   
                   
                 acid 
               
               
                 LTB4 
                 Ebselen 
                 2-Phenyl- 
                 Journal of Cerebral Blood Flow and 
               
               
                 Receptor 
                   
                 benzo[d]isoselenazol-3- 
                 Metabolism 1995, July 2-6 (S162); 
               
               
                 Antagonist 
                   
                 one 
                 Drugs of the Future 1995, 20: 10 
               
               
                   
                   
                   
                 (1057) 
               
               
                 LTB4 
                 LTB 019; 
                 4-[5-(4-Carbamimidoyl- 
                 ACS Meeting 1994, 207th: San Diego 
               
               
                 Receptor 
                 CGS- 
                 phenoxy)-pentyloxy]-N,N- 
                 (MEDI 003); International Congress 
               
               
                 Antagonist 
                 25019C 
                 diisopropyl-3-methoxy- 
                 of the Inflammation Research 
               
               
                   
                   
                 benzamide maleate 
                 Association 1994, 7th: White Haven 
               
               
                   
                   
                   
                 (Abs W23) 
               
               
                 LTB4 
                 LY 210073 
                 5-(2-Carboxy-ethyl)-6-[6- 
                 J Med Chem 1993 36 (12) 1726-1734 
               
               
                 Receptor 
                   
                 (4-methoxy-phenyl)-hex- 
               
               
                 Antagonist 
                   
                 5-enyloxy]-9-oxo-9H- 
               
               
                   
                   
                 xanthene-2-carboxylic 
               
               
                   
                   
                 acid 
               
               
                 LTB4 
                 LY 213024 
                 5-(3-carboxybenzoyl)-2- 
                 J Med Chem 1993 36 (12) 1726-1734 
               
               
                 Receptor 
                   
                 (decyloxy)benzenepropanoic 
               
               
                 Antagonist 
                   
                 acid 
               
               
                 LTB4 
                 LY 255283 
                 1-[5-ethyl-2-hydroxy-4- 
                 EP 276064 B 1990, priority US 2479 
               
               
                 Receptor 
                   
                 [[6-methyl-6-(1H- 
                 1987 
               
               
                 Antagonist 
                   
                 tetrazol-5- 
               
               
                   
                   
                 yl)heptyl]oxy]phenyl]ethanone 
               
               
                 LTB4 
                 LY 264086 
                 7-carboxy-3-(decyloxy)-9- 
                 U.S. Pat. No. 4,996,230 1991, priority US 481413 
               
               
                 Receptor 
                   
                 oxo-9H-xanthene-4- 
                 1990 
               
               
                 Antagonist 
                   
                 propanoic acid 
               
               
                 LTB4 
                 LY 292728 
                 7-carboxy-3-[3-[(5-ethyl- 
                 EP 743064 A 1996, priority US 
               
               
                 Receptor 
                   
                 4′-fluoro-2-hydroxy[1,1′- 
                 443179 1995 
               
               
                 Antagonist 
                   
                 biphenyl]-4-yl)oxy]propoxy]- 
               
               
                   
                   
                 9-oxo-9H- 
               
               
                   
                   
                 xanthene-4-propanoic acid 
               
               
                   
                   
                 disodium salt 
               
               
                 LTB4 
                 LY-293111 
                 Benzoic acid,2-(3-(3-((5- 
                 Proceedings of the American Society 
               
               
                 Receptor 
                 (VML-295) 
                 ethyl-4′-fluoro-2- 
                 for Clinical Oncology 2002, 21: 1 
               
               
                 Antagonist 
                   
                 hydroxy(1,1′-biphenyl)-4- 
                 (Abs 343) [LY-293111 for Cancer] 
               
               
                   
                   
                 yl)oxy)propoxy)-2- 
                 SCRIP World Pharmaceutical News 
               
               
                   
                   
                 propylphenoxy)- 
                 1997, 2272 (13) [for VML-295] 
               
               
                 LTB4 
                 ONO 4057; 
                 (E)-2-(4-carboxybutoxy)- 
                 EP 405116 A 1991 
               
               
                 Receptor 
                 LB 457 
                 6-[[6-(4-methoxyphenyl)- 
               
               
                 Antagonist 
                   
                 5- 
               
               
                   
                   
                 hexenyl]oxy]benzenepropanoic 
               
               
                   
                   
                 acid 
               
               
                 LTB4 
                 PF 10042 
                 1-[5-hydroxy-5-[8-(1- 
                 EP 422329 B 1995, priority US 
               
               
                 Receptor 
                   
                 hydroxy-2-phenylethyl)-2- 
                 409630 1989 
               
               
                 Antagonist 
                   
                 dibenzofuranyl]-1-oxo 
               
               
                   
                   
                 pentyl]pyrrolidine 
               
               
                 LTB4 
                 RG-14893 
                 8-Benzyloxy-4-[(methyl- 
                 SCRIP World Pharmaceutical News 
               
               
                 Receptor 
                   
                 phenethyl-carbamoyl)- 
                 1996, 2168 (20) 
               
               
                 Antagonist 
                   
                 methyl]-naphthalene-2- 
               
               
                   
                   
                 carboxylic acid 
               
               
                 LTB4 
                 SB-201993 
                 3-{6-(2-Carboxy-vinyl)-5- 
                 WO-09500487 
               
               
                 Receptor 
                   
                 [8-(4-methoxy-phenyl)- 
               
               
                 Antagonist 
                   
                 octyloxy]-pyridin-2- 
               
               
                   
                   
                 ylmethylsulfanylmethyl}- 
               
               
                   
                   
                 benzoic acid 
               
               
                 LTB4 
                 SC-52798 
                 7-[3-(2- 
                 Bioorganic and Medicinal Chemistry 
               
               
                 Receptor 
                   
                 Cyclopropylmethyl-3- 
                 Letters 1994, 4: 6 (811-816); Journal 
               
               
                 Antagonist 
                   
                 methoxy-4-thiazol-4-yl- 
                 of Medicinal Chemistry 1995, 38: 6 
               
               
                   
                   
                 phenoxy)-propoxy]-8- 
                 (858-868) 
               
               
                   
                   
                 propyl-chroman-2- 
               
               
                   
                   
                 carboxylic acid 
               
               
                 LTB4 
                 SC-53228 
                 3-{7-[3-(2- 
                 International Congress of the 
               
               
                 Receptor 
                   
                 Cyclopropylmethyl-3- 
                 Inflammation Research Association 
               
               
                 Antagonist 
                   
                 methoxy-4- 
                 1994, 7th: White Haven (Abs W5) 
               
               
                   
                   
                 methylcarbamoyl- 
               
               
                   
                   
                 phenoxy)-propoxy]-8- 
               
               
                   
                   
                 propyl-chroman-2-yl}- 
               
               
                   
                   
                 propionic acid 
               
               
                 LTB4 
                 WAY 
                 3-fluoro-4′-(2- 
                 Drugs under Experimental and Clinical 
               
               
                 Receptor 
                 121006 
                 quinolinylmethoxy)-[1,1′- 
                 research 1991, 17: 8 (381-387) 
               
               
                 Antagonist 
                   
                 biphenyl]-4-acetic acid 
               
               
                 LTB4 
                 ZD-2138 
                 3-Amino-3-(4-methoxy- 
                 International Symposium on Medicinal 
               
               
                 Receptor 
                   
                 tetrahydro-pyran-4-yl)- 
                 Chemistry 1994, 13th: Paris (P 197) 
               
               
                 Antagonist 
                   
                 acrylic acid 1-methyl-2- 
               
               
                   
                   
                 oxo-1,2-dihydro-quinolin- 
               
               
                   
                   
                 6-ylmethyl ester 
               
               
                   
               
            
           
         
       
     
     Alternatively, biological networks or metabolic pathways related to the markers and haplotypes of the present invention can be monitored by determining mRNA and/or polypeptide levels. This can be done for example, by monitoring expression levels or polypeptides for several genes belonging to the network and/or pathway, in samples taken before and during treatment. Alternatively, metabolites belonging to the biological network or metabolic pathway can be determined before and during treatment. Effectiveness of the treatment is determined by comparing observed changes in expression levels/metabolite levels during treatment to corresponding data from healthy subjects. 
     In a further aspect, the markers of the present invention can be used to increase power and effectiveness of clinical trials. Thus, individuals who are carriers of the at-risk variants of the present invention may be more likely to respond to a particular treatment modality. In one embodiment, individuals who carry at-risk variants for gene(s) in a pathway and/or metabolic network for which a particular treatment (e.g., small molecule drug, e.g. the small molecule drugs as listed in the above, e.g., the drugs listed in Agent Table I and Agent Table II) is targeting, are more likely to be responders to the treatment. In another embodiment, individuals who carry at-risk variants for a gene, which expression and/or function is altered by the at-risk variant, are more likely to be responders to a treatment modality targeting that gene, its expression or its gene product. 
     In a further aspect, the markers and haplotypes of the present invention can be used for targeting the selection of pharmaceutical agents for specific individuals. Personalized selection of treatment modalities, lifestyle changes (e.g., change in diet, exercise, weight loss program, smoking abstinence, less stressful lifestyle, etc.) or combination of the two, can be realized by the utilization of the at-risk variants of the present invention. Thus, the knowledge of an individual&#39;s status for particular markers of the present invention, can be useful for selection of treatment options that target genes or gene products affected by the at-risk variants of the invention. Certain combinations of variants may be suitable for one selection of treatment options, while other gene variant combinations may target other treatment options. Such combination of variant may include one variant, two variants, three variants, or four or more variants, as needed to determine with clinically reliable accuracy the selection of treatment module. 
     Computer-Implemented Aspects 
     The present invention also relates to computer-implemented applications of the polymorphic markers and haplotypes described herein to be associated with coronary artery disease and myocardial infarction. Such applications can be useful for storing, manipulating or otherwise analyzing genotype data that is useful in the methods of the invention. One example pertains to storing genotype information derived from an individual on readable media, so as to be able to provide the genotype information to a third party (e.g., the individual), or for deriving information from the genotype data, e.g., by comparing the genotype data to information about genetic risk factors contributing to increased susceptibility to coronary artery disease and/or myocardial infarction, and reporting results based on such comparison. 
     One such aspect relates to computer-readable media. In general terms, such medium has capabilities of storing (i) identifier information for at least one polymorphic marker or a haplotype; (ii) an indicator of the frequency of at least one allele of said at least one marker, or the frequency of a haplotype, in individuals with coronary artery disease and/or myocardial infarction; and an indicator of the frequency of at least one allele of said at least one marker, or the frequency of a haplotype, in a reference population. The reference population can be a disease-free population of individuals. Alternatively, the reference population is a random sample from the general population, and is thus representative of the population at large. The frequency indicator may be a calculated frequency, a count of alleles and/or haplotype copies, or normalized or otherwise manipulated values of the actual frequencies that are suitable for the particular medium. 
     Additional information about the individual can be stored on the medium, such as ancestry information, information about sex, physical attributes or characteristics (including height and weight), biochemical measurements (such as blood pressure, blood lipid levels, lipid levels, such as cholesterol levels), biomarkers relevant for cardiovascular disease, as described further herein, or other useful information that is desirable to store or manipulate in the context of the genotype status of a particular individual. 
     The invention furthermore relates to an apparatus that is suitable for determination or manipulation of genetic data useful for determining a susceptibility to coronary artery disease and/or myocardial infarction in a human individual. Such an apparatus can include a computer-readable memory, a routine for manipulating data stored on the computer-readable memory, and a routine for generating an output that includes a measure of the genetic data. Such measure can include values such as allelic or haplotype frequencies, genotype counts, sex, age, phenotype information, values for odds ratio (OR) or relative risk (RR), population attributable risk (PAR), or other useful information that is either a direct statistic of the original genotype data or based on calculations based on the genetic data. 
     The markers and haplotypes shown herein to be associated with increased susceptibility (e.g., increased risk) of cardiovascular disease, are in certain embodiments useful for interpretation and/or analysis of genotype data. Thus in certain embodiments, an identification of an at-risk allele for coronary artery disease and/or myocardial infarction, as shown herein, or an allele at a polymorphic marker in LD with any one of the markers shown herein to be associated with coronary artery disease and/or myocardial infarction, is indicative of the individual from whom the genotype data originates is at increased risk of coronary artery disease and/or myocardial infarction. In one such embodiment, genotype data is generated for at least one polymorphic marker shown herein to be associated with coronary artery disease and/or myocardial infarction, or a marker in linkage disequilibrium therewith. The genotype data is subsequently made available to a third party, such as the individual from whom the data originates, for example via a user interface accessible over the internet, together with an interpretation of the genotype data, e.g., in the form of a risk measure (such as an absolute risk (AR), risk ratio (RR) or odds ration (OR)) for the cardiovascular disease. In another embodiment, at-risk markers identified in a genotype dataset derived from an individual are assessed and results from the assessment of the risk conferred by the presence of such at-risk variants in the dataset are made available to the individual, for example via a secure web interface, or by other communication means. The results of such risk assessment can be reported in numeric form (e.g., by risk values, such as absolute risk, relative risk, and/or an odds ratio, or by a percentage increase in risk compared with a reference), by graphical means, or by other means suitable to illustrate the risk to the individual from whom the genotype data is derived. In particular embodiments, the results of risk assessment is made available to a third party, e.g., a physician, other healthcare worker or genetic counselor. 
     Markers Useful in Various Aspects of the Invention 
     The above-described applications can all be practiced with the markers and haplotypes of the invention that have in more detail been described with respect to methods of assessing susceptibility to cardiovascular disease and described in detail herein. Thus, these applications can in general be reduced to practice using any of the markers listed in Tables 1-5 herein, and markers in linkage disequilibrium therewith. In some embodiments, the markers are selected from the markers set forth in Table 3, and markers in linkage disequilibrium therewith. In some other embodiments, the markers are selected from the markers set forth in Table 4, and markers in linkage disequilibrium therewith. In some other embodiments, the markers are selected from the markers rs11751605 (SEQ ID NO:1), rs6076623 (SEQ ID NO:2), rs1412444 (SEQ ID NO:3), rs2163612 (SEQ ID NO:4), rs1029396 (SEQ ID NO:5), rs2243547 (SEQ ID NO:6), rs12534186 (SEQ ID NO:7), rs12134779 (SEQ ID NO:8) and rs7158073 (SEQ ID NO:9), and markers in linkage disequilibrium therewith. In some other embodiments, the markers are selected from the markers rs11751605 (SEQ ID NO:1), rs6076623 (SEQ ID NO:2), rs1412444 (SEQ ID NO:3), rs2163612 (SEQ ID NO:4), and rs1029396 (SEQ ID NO:5), and markers in linkage disequilibrium therewith. In some preferred embodiments, the marker is selected from rs11751605 (SEQ ID NO:1), and markers in linkage disequilibrium therewith. In other preferred embodiments, the marker is selected from rs6076623 (SEQ ID NO:2), and markers in linkage disequilibrium therewith. In yet other preferred embodiments, the marker is selected from rs1412444 (SEQ ID NO:3), and markers in linkage disequilibrium therewith. In other preferred embodiments, the marker is selected from rs2163612 (SEQ ID NO:4), and markers in linkage disequilibrium therewith. The marker may also be selected from rs1029396 (SEQ ID NO:5), and markers in linkage disequilibrium therewith. In a particularly preferred embodiment, the marker is rs11751605 (SEQ ID NO:1). In preferred embodiments, linkage disequilibrium between markers is defined by numerical values for r 2  of greater than 0.2. 
     In some embodiments, the presence of allele C in rs11751605, allele T in rs6076623, allele A in rs1412444, allele G in rs2163612 or allele G in rs1029396 is indicative of increased susceptibility of coronary artery disease or myocardial infarction in the individual who is undergoing testing, through analysis of genotype information (genotype dataset) derived from the individual, or through analysis of a sample comprising genomic DNA from the individual. 
     Nucleic Acids and Polypeptides 
     The nucleic acids and polypeptides described herein can be used in methods and kits of the present invention. An “isolated” nucleic acid molecule, as used herein, is one that is separated from nucleic acids that normally flank the gene or nucleotide sequence (as in genomic sequences) and/or has been completely or partially purified from other transcribed sequences (e.g., as in an RNA library). For example, an isolated nucleic acid of the invention can be substantially isolated with respect to the complex cellular milieu in which it naturally occurs, or culture medium when produced by recombinant techniques, or chemical precursors or other chemicals when chemically synthesized. In some instances, the isolated material will form part of a composition (for example, a crude extract containing other substances), buffer system or reagent mix. In other circumstances, the material can be purified to essential homogeneity, for example as determined by polyacrylamide gel electrophoresis (PAGE) or column chromatography (e.g., HPLC). An isolated nucleic acid molecule of the invention can comprise at least about 50%, at least about 80% or at least about 90% (on a molar basis) of all macromolecular species present. With regard to genomic DNA, the term “isolated” also can refer to nucleic acid molecules that are separated from the chromosome with which the genomic DNA is naturally associated. For example, the isolated nucleic acid molecule can contain less than about 250 kb, 200 kb, 150 kb, 100 kb, 75 kb, 50 kb, 25 kb, 10 kb, 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb or 0.1 kb of the nucleotides that flank the nucleic acid molecule in the genomic DNA of the cell from which the nucleic acid molecule is derived. 
     The nucleic acid molecule can be fused to other coding or regulatory sequences and still be considered isolated. Thus, recombinant DNA contained in a vector is included in the definition of “isolated” as used herein. Also, isolated nucleic acid molecules include recombinant DNA molecules in heterologous host cells or heterologous organisms, as well as partially or substantially purified DNA molecules in solution. “Isolated” nucleic acid molecules also encompass in vivo and in vitro RNA transcripts of the DNA molecules of the present invention. An isolated nucleic acid molecule or nucleotide sequence can include a nucleic acid molecule or nucleotide sequence that is synthesized chemically or by recombinant means. Such isolated nucleotide sequences are useful, for example, in the manufacture of the encoded polypeptide, as probes for isolating homologous sequences (e.g., from other mammalian species), for gene mapping (e.g., by in situ hybridization with chromosomes), or for detecting expression of the gene in tissue (e.g., human tissue), such as by Northern blot analysis or other hybridization techniques. 
     The invention also pertains to nucleic acid molecules that hybridize under high stringency hybridization conditions, such as for selective hybridization, to a nucleotide sequence described herein (e.g., nucleic acid molecules that specifically hybridize to a nucleotide sequence containing a polymorphic site associated with a haplotype described herein). In one embodiment, the invention includes variants that hybridize under high stringency hybridization and wash conditions (e.g., for selective hybridization) to a nucleotide sequence that comprises the nucleotide sequence according to any one of SEQ ID NO:1-172 or a fragment thereof (or a nucleotide sequence comprising the complement of the nucleotide sequence of any one of SEQ ID NO:1-172), wherein the nucleotide sequence comprises at least one at-risk allele of at least one polymorphic marker, or at least one haplotype, as described herein. 
     The percent identity of two nucleotide or amino acid sequences can be determined by aligning the sequences for optimal comparison purposes (e.g., gaps can be introduced in the sequence of a first sequence). The nucleotides or amino acids at corresponding positions are then compared, and the percent identity between the two sequences is a function of the number of identical positions shared by the sequences (i.e., % identity=# of identical positions/total # of positions×100). In certain embodiments, the length of a sequence aligned for comparison purposes is at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 95%, of the length of the reference sequence. The actual comparison of the two sequences can be accomplished by well-known methods, for example, using a mathematical algorithm. A non-limiting example of such a mathematical algorithm is described in Karlin, S, and Altschul, S.,  Proc. Natl. Acad. Sci. USA,  90:5873-5877 (1993). Such an algorithm is incorporated into the NBLAST and XBLAST programs (version 2.0), as described in Altschul, S. et al.,  Nucleic Acids Res.,  25:3389-3402 (1997). When utilizing BLAST and Gapped BLAST programs, the default parameters of the respective programs (e.g., NBLAST) can be used. See the website on the world wide web at ncbi.nlm.nih.gov. In one embodiment, parameters for sequence comparison can be set at score=100, wordlength=12, or can be varied (e.g., W=5 or W=20). Another example of an algorithm is BLAT (Kent, W. J.  Genome Res.  12:656-64 (2002)). 
     The present invention also provides isolated nucleic acid molecules that contain a fragment or portion that hybridizes under highly stringent conditions to a nucleic acid that comprises, or consists of, the nucleotide sequence of any one of SEQ ID NO:1-172, or a nucleotide sequence comprising, or consisting of, the complement of the nucleotide sequence of any one of SEQ ID NO:1-172, wherein the nucleotide sequence comprises at least one polymorphic allele contained in the markers and haplotypes described herein. The nucleic acid fragments of the invention are at least about 15, at least about 18, 20, 23 or 25 nucleotides, and can be 30, 40, 50, 100, 200, 500, 1000, 10,000 or more nucleotides in length. 
     The nucleic acid fragments of the invention are used as probes or primers in assays such as those described herein. “Probes” or “primers” are oligonucleotides that hybridize in a base-specific manner to a complementary strand of a nucleic acid molecule. In addition to DNA and RNA, such probes and primers include polypeptide nucleic acids (PNA), as described in Nielsen, P. et al.,  Science  254:1497-1500 (1991). A probe or primer comprises a region of nucleotide sequence that hybridizes to at least about 15, typically about 20-25, and in certain embodiments about 40, 50 or 75, consecutive nucleotides of a nucleic acid molecule comprising a contiguous nucleotide sequence from any one of SEQ ID NO:1-172 and comprising at least one allele of at least one polymorphic marker or at least one haplotype described herein, or the complement thereof. In particular embodiments, a probe or primer can comprise 100 or fewer nucleotides; for example, in certain embodiments from 6 to 50 nucleotides, or, for example, from 12 to 30 nucleotides. In other embodiments, the probe or primer is at least 70% identical, at least 80% identical, at least 85% identical, at least 90% identical, or at least 95% identical, to the contiguous nucleotide sequence or to the complement of the contiguous nucleotide sequence. In another embodiment, the probe or primer is capable of selectively hybridizing to the contiguous nucleotide sequence or to the complement of the contiguous nucleotide sequence. Often, the probe or primer further comprises a label, e.g., a radioisotope, a fluorescent label, an enzyme label, an enzyme co-factor label, a magnetic label, a spin label, an epitope label. 
     The nucleic acid molecules of the invention, such as those described above, can be identified and isolated using standard molecular biology techniques and the sequence information provided by the nucleotide sequence of any one of SEQ ID NO:1-172. See generally  PCR Technology: Principles and Applications for DNA Amplification  (ed. H.A. Erlich, Freeman Press, NY, N.Y., 1992);  PCR Protocols: A Guide to Methods and Applications  (Eds. Innis, et al., Academic Press, San Diego, Calif., 1990); Mattila, P. et al.,  Nucleic Acids Res.,  19:4967-4973 (1991); Eckert, K. and Kunkel, T.,  PCR Methods and Applications,  1:17-24 (1991); PCR (eds. McPherson et al., IRL Press, Oxford); and U.S. Pat. No. 4,683,202, the entire teachings of each of which are incorporated herein by reference. 
     Antibodies 
     Polyclonal antibodies and/or monoclonal antibodies that specifically bind one form of the gene product but not to the other form of the gene product (such as Lipoprotein(a), including kringle IV variants of Lipoprotein(a)) are also provided. Antibodies are also provided which bind a portion of either the variant or the reference gene product that contains the polymorphic site or sites. The term “antibody” as used herein refers to immunoglobulin molecules and immunologically active portions of immunoglobulin molecules, i.e., molecules that contain antigen-binding sites that specifically bind an antigen. A molecule that specifically binds to a polypeptide of the invention is a molecule that binds to that polypeptide or a fragment thereof, but does not substantially bind other molecules in a sample, e.g., a biological sample, which naturally contains the polypeptide. Examples of immunologically active portions of immunoglobulin molecules include F(ab) and F(ab′) 2  fragments which can be generated by treating the antibody with an enzyme such as pepsin. The invention provides polyclonal and monoclonal antibodies that bind to a polypeptide of the invention. The term “monoclonal antibody” or “monoclonal antibody composition”, as used herein, refers to a population of antibody molecules that contain only one species of an antigen binding site capable of immunoreacting with a particular epitope of a polypeptide of the invention. A monoclonal antibody composition thus typically displays a single binding affinity for a particular polypeptide of the invention with which it immunoreacts. 
     Polyclonal antibodies can be prepared as described above by immunizing a suitable subject with a desired immunogen, e.g., polypeptide of the invention or a fragment thereof. The antibody titer in the immunized subject can be monitored over time by standard techniques, such as with an enzyme linked immunosorbent assay (ELISA) using immobilized polypeptide. If desired, the antibody molecules directed against the polypeptide can be isolated from the mammal (e.g., from the blood) and further purified by well-known techniques, such as protein A chromatography to obtain the IgG fraction. At an appropriate time after immunization, e.g., when the antibody titers are highest, antibody-producing cells can be obtained from the subject and used to prepare monoclonal antibodies by standard techniques, such as the hybridoma technique originally described by Kohler and Milstein,  Nature  256:495-497 (1975), the human B cell hybridoma technique (Kozbor et al.,  Immunol. Today  4: 72 (1983)), the EBV-hybridoma technique (Cole et al.,  Monoclonal Antibodies and Cancer Therapy , Alan R. Liss, 1985, Inc., pp. 77-96) or trioma techniques. The technology for producing hybridomas is well known (see generally  Current Protocols in Immunology  (1994) Coligan et al., (eds.) John Wiley &amp; Sons, Inc., New York, N.Y.). Briefly, an immortal cell line (typically a myeloma) is fused to lymphocytes (typically splenocytes) from a mammal immunized with an immunogen as described above, and the culture supernatants of the resulting hybridoma cells are screened to identify a hybridoma producing a monoclonal antibody that binds a polypeptide of the invention. 
     Any of the many well known protocols used for fusing lymphocytes and immortalized cell lines can be applied for the purpose of generating a monoclonal antibody to a polypeptide of the invention (see, e.g.,  Current Protocols in Immunology , supra; Galfre et al.,  Nature  266:55052 (1977); R. H. Kenneth, in  Monoclonal Antibodies: A New Dimension In Biological Analyses , Plenum Publishing Corp., New York, N.Y. (1980); and Lerner,  Yale J. Biol. Med.  54:387-402 (1981)). Moreover, the ordinarily skilled worker will appreciate that there are many variations of such methods that also would be useful. 
     Alternative to preparing monoclonal antibody-secreting hybridomas, a monoclonal antibody to a polypeptide of the invention can be identified and isolated by screening a recombinant combinatorial immunoglobulin library (e.g., an antibody phage display library) with the polypeptide to thereby isolate immunoglobulin library members that bind the polypeptide. Kits for generating and screening phage display libraries are commercially available (e.g., the Pharmacia  Recombinant Phage Antibody System , Catalog No. 27-9400-01; and the Stratagene SurfZAP™ Phage Display Kit, Catalog No. 240612). Additionally, examples of methods and reagents particularly amenable for use in generating and screening antibody display library can be found in, for example, U.S. Pat. No. 5,223,409; PCT Publication No. WO 92/18619; PCT Publication No. WO 91/17271; PCT Publication No. WO 92/20791; PCT Publication No. WO 92/15679; PCT Publication No. WO 93/01288; PCT Publication No. WO 92/01047; PCT Publication No. WO 92/09690; PCT Publication No. WO 90/02809; Fuchs et al.,  Bio/Technology  9: 1370-1372 (1991); Hay et al., H um. Antibod. Hybridomas  3:81-85 (1992); Huse et al.,  Science  246: 1275-1281 (1989); and Griffiths et al.,  EMBO J.  12:725-734 (1993). 
     Additionally, recombinant antibodies, such as chimeric and humanized monoclonal antibodies, comprising both human and non-human portions, which can be made using standard recombinant DNA techniques, are within the scope of the invention. Such chimeric and humanized monoclonal antibodies can be produced by recombinant DNA techniques known in the art. 
     In general, antibodies of the invention (e.g., a monoclonal antibody) can be used to isolate a polypeptide of the invention by standard techniques, such as affinity chromatography or immunoprecipitation. A polypeptide-specific antibody can facilitate the purification of natural polypeptide from cells and of recombinantly produced polypeptide expressed in host cells. Moreover, an antibody specific for a polypeptide of the invention can be used to detect the polypeptide (e.g., in a cellular lysate, cell supernatant, or tissue sample) in order to evaluate the abundance and pattern of expression of the polypeptide. Antibodies can be used diagnostically to monitor protein levels in tissue as part of a clinical testing procedure, e.g., to, for example, determine the efficacy of a given treatment regimen. The antibody can be coupled to a detectable substance to facilitate its detection. Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, beta-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include  125 I,  131 I,  35 S or  3 H. 
     Antibodies may also be useful in pharmacogenomic analysis. In such embodiments, antibodies against variant proteins encoded by nucleic acids according to the invention (for example, variant forms of Lipoprotein(a), such as kringle IV repeat polymorphisms), such as variant proteins that are encoded by nucleic acids that contain at least one polymorphic marker of the invention, can be used to identify individuals that require modified treatment modalities. 
     Antibodies can furthermore be useful for assessing expression of variant proteins in disease states, such as in active stages of a cardiovascular disease, or in an individual with a predisposition to a disease related to the function of the protein, in particular a cardiovascular disease. Examples are provided by biomarker (e.g., cardiac markers), as described further herein. Antibodies specific for a variant protein of the present invention that is encoded by a nucleic acid that comprises at least one polymorphic marker or haplotype as described herein (e.g., CDKN2A and/or CDKN2B) can be used to screen for the presence of the variant protein, for example to screen for a predisposition to cardiovascular disease as indicated by the presence of the variant protein. 
     Antibodies can be used in other methods. Thus, antibodies are useful as diagnostic tools for evaluating proteins, such as variant proteins of the invention (e.g., variants of Lipoprotein(a), such as kringle IV repeat variants), in conjunction with analysis by electrophoretic mobility, isoelectric point, tryptic or other protease digest, or for use in other physical assays known to those skilled in the art. Antibodies may also be used in tissue typing. In one such embodiment, a specific variant protein has been correlated with expression in a specific tissue type, and antibodies specific for the variant protein can then be used to identify the specific tissue type. 
     Subcellular localization of proteins, including variant proteins, can also be determined using antibodies, and can be applied to assess aberrant subcellular localization of the protein in cells in various tissues. Such use can be applied in genetic testing, but also in monitoring a particular treatment modality. In the case where treatment is aimed at correcting the expression level or presence of the variant protein or aberrant tissue distribution or developmental expression of the variant protein, antibodies specific for the variant protein or fragments thereof can be used to monitor therapeutic efficacy. 
     Antibodies are further useful for inhibiting variant protein function (e.g., Lipoprotein(a)), for example by blocking the binding of a variant protein to a binding molecule or partner. Such uses can also be applied in a therapeutic context in which treatment involves inhibiting a variant protein&#39;s function. An antibody can be for example be used to block or competitively inhibit binding, thereby modulating (i.e., agonizing or antagonizing) the activity of the protein. Antibodies can be prepared against specific protein fragments containing sites required for specific function or against an intact protein that is associated with a cell or cell membrane. For administration in vivo, an antibody may be linked with an additional therapeutic payload, such as radionuclide, an enzyme, an immunogenic epitope, or a cytotoxic agent, including bacterial toxins (diphtheria or plant toxins, such as ricin). The in vivo half-life of an antibody or a fragment thereof may be increased by pegylation through conjugation to polyethylene glycol. 
     The present invention further relates to kits for using antibodies in the methods described herein. This includes, but is not limited to, kits for detecting the presence of a variant protein in a test sample. One preferred embodiment comprises antibodies such as a labelled or labelable antibody and a compound or agent for detecting variant proteins in a biological sample, means for determining the amount or the presence and/or absence of variant protein in the sample, and means for comparing the amount of variant protein in the sample with a standard, as well as instructions for use of the kit. 
     The present invention will now be exemplified by the following non-limiting examples. 
     EXEMPLIFICATION 
     Example 1 
     The following contains description of the identification of susceptibility factors found to be associated with coronary artery disease and myocardial infarction through single-point analysis of SNP markers and microsatellite markers. 
     Methods 
     The study was approved by the Data Protection Commission of Iceland and the National Bioethics Committee. 
     Icelandic Coronary Artery Disease Cohort 
     Over the last eight years individuals who have suffered an MI we have been recruited through cardiovascular disease (CVD) genetic programs at deCODE. Currently blood samples have been collected from 2525 MI patients. The individuals who had suffered an MI were identified from a registry of over 10,000 individuals who: a) had an MI before the age of 75 in Iceland in the years 1981 to 2002 and satisfy the MONICA criteria ( J Clin Epidemiol  41, 105-14 (1988)); b) participated in a large prospective epidemiology study (1) done by the Icelandic Heart Association (IHA) over the past 30 years and had MI prior to 1981; c) had MI discharge diagnosis from the major hospitals in Reykjavik in the years 2003 and 2004. MI diagnoses of all individuals in the registry follow strict diagnostic rules based on signs, symptoms, electrocardiograms, cardiac enzymes and necropsy findings (2). The patients were contacted through collaborating physicians in the CVD genetic programs at deCODE. Most of the participants in the study visited the IHA and had their blood drawn, although participants who lived outside the Reykjavik area visited their local health care center. 
     Additional subjects with coronary artery disease, but are without known history of myocardial infarction, are identified from a list of those who have undergone coronary stent procedure in the major hospitals in Reykjavik in the years 1993 and 2003. 
     The controls used for the study were recruited as a part of various genetic programs at deCODE. The medical history for the controls were unknown unless if the control subjects also had participated in any of the CVD genetic programs (i.e. MI, stroke, peripheral vascular disease, type II diabetes, obesity, familial combined hyperlipidemia, coronary restenosis, and hypertension genetic programs). Individuals with known MI, stroke, peripheral vascular or coronary artery disease were excluded as controls. 
     Subjects from the United States
 
Cohort from Philadelphia
 
     The study participants from Philadelphia were enrolled at the University of Pennsylvania Medical Center through the PENN CATH study program which studies the association of biochemical and genetic factors to coronary artery disease (CAD) in subjects undergoing cardiac catheterization. A total of 3850 subjects have participated. For the purpose of the current study we selected from the PENN CATH study individuals diagnosed with one of the following coronary artery disease: MI based on criteria for acute MI in terms of elevations of cardiac enzymes and electrocardiographic changes, or a self-reported history of MI, history of coronary artery bypass surgery (CABG) or percutaneous, transluminal coronary angioplasty (PTCA). To use as controls we selected individuals who were without significant luminal stenosis on coronary angiography (luminal stenosis less than 50%). Ethnicity information was self-reported. 
     The University of Pennsylvania Institutional Review Board approved the study and all subjects provided written informed consent. 
     Cohort from Durham, N.C. 
     The study participants were enrolled at Duke University Medical Center (Durham, N.C.) through the CATHGEN biorepository, recruited sequentially through the cardiac catheterization laboratories from 2001-2005. Biological samples and extensive clinical, angiographic, and longitudinal follow-up data were collected on all subjects consenting to participation. For purposes of this study, cases of MI were defined as those having a history of MI (by self-report and corroborated by review of medical records), or having suffered an MI during the study follow-up period. Controls from this cohort, defined as those with no history of MI prior or subsequent to the index cardiac catheterization, as well as no history of percutaneous or surgical coronary revascularization procedure; no subsequent percutaneous or surgical coronary revascularization procedures; ejection fraction on left ventriculogram greater than 40%; and no or minimal CAD on coronary angiography (defined as a CAD index less than or equal to 23 and no coronary vessel with clinically significant CAD (stenosis greater than 50%)). This study was approved by the Duke University Medical Center Institutional Review Board on Human Subjects and all subjects gave written informed consent. 
     Cohort from Atlanta 
     The study participants were enrolled at the Emory University Hospital, the Emory Clinic and Grady Memorial Hospitals through its Emory Genebank study and Clinical Registry in Neurology (CRIN). The Emory Genebank studies the association of biochemical and genetic factors with CAD in subjects undergoing cardiac catheterization. For the purpose of the current study those subjects who had a self-reported history of MI, CABG, or PTCA, were selected and used as a patient group. Control subjects were selected from a group of individuals with non-vascular neurological diseases (mainly Parkinson&#39;s and Alzheimer&#39;s diseases) recruited from CRIN, their spouses, unrelated friends and community volunteers. These subjects were matched for age, and ethnicity to the patient population. Controls were excluded if they had a known history of MI or coronary artery disease. All subjects provided written informed consent. Information on ethnicity was self-reported. 
     Genotyping 
     A genome-wide scan of 1700 Icelandic individuals diagnosed with myocardial infarction (MI), 2034 patients with coronary artery disease and 10635 population controls was performed using Infinium HumanHap300 SNP chips from Illumina for assaying approximately 317,000 single nucleotide polymorphisms (SNPs) on a single chip (Illumina, San Diego, Calif., USA). SNP genotyping for replication in other case-control cohorts was carried using the Centaurus platform (Nanogen). 
     Statistical Methods for Association Analysis. 
     To test individual markers for association to disease phenotypes such as coronary artery disease or myocardial infarction, we use a likelihood ratio test to calculate a two-sided P-value for each allele of the markers. We calculate relative risk (RR) and population attributable risk (PAR) assuming a multiplicative model (C. T. Falk, P. Rubinstein,  Ann Hum Genet  51 (Pt 3), 227 (1987); J. D. Terwilliger, J. Ott,  Hum Hered  42, 337 (1992)). To elucidate the linkage disequilibrium between markers in the region we used the CEPH Caucasian HapMap data. We calculated LD between pairs of SNPs using the standard definition of D′ (R. C. Lewontin,  Genetics  50, 757 (1964)) and for the correlation coefficient r 2  (W. G. Hill, A. Robertson,  Genetics  60, 615 (November, 1968). For the Icelandic cohort, to take into account that some of the individuals are related to each other, we obtained the null statistic of the test statistic either by simulating genotypes through the Icelandic genealogy or from the test statistic for all the 300,000 tested for association in the initial genome-wide association scan (citation). Model-free estimates of the genotype relative risk are generated as follows: RR of genotype G 1  compared to genotype G 0  was estimated by [n(G 1 )/n(G 0 )]/[m(G 1 )/m(G 0 )] where n and m denote genotype counts in patients and controls respectively. Results from different cohorts were combined using a Mantel-Hanezel model (citation) where cohorts are allowed to have different population frequencies for the alleles/genotypes but assume to have common relative risks. 
     We use multiple regression to test for association between markers and quantitative traits, such as ago of onset of MI in the cases, where the number of copies of the at-risk variant carried by an individual is taken as explanatory variable and the quantitative trait as the response variable. The association is adjusted for age and gender, where appropriate, by including corresponding terms in the regression analysis as explanatory variables. 
     Results 
     Genome-Wide Association Study 
     We successfully genotyped 1700 Icelandic myocardial infarction patients, 2034 coronary artery disease Patients and 10635 population control individuals without known history of coronary artery disease (Cohort A) using the Illumina 330K chip. We performed a genome-wide scan for association to MI, testing individually each of the 309,091 SNPs that was successfully genotyped. Results of this association analysis is presented in Table 1, wherein markers showing significant association to MI are indicated (p-value less than 0.01). As can be seen in the table, a large number of markers show significant association to MI, including markers rs2227165 on chromosome X, rs12304836 on chromosome 12 and rs11225090 on chromosome 11. 
     The markers found to be associating with MI as presented in Table 1 may be useful for risk assessment and diagnostic purposes for MI, either alone or in combination. Even in the cases where the increase in risk by individual markers is relatively modest, i.e. on the order of 15-30%, the association may have significant implications. Thus, relatively common variants may have significant contribution to the overall risk (Population Attributable Risk is high), or combination of markers can be used to define groups of individual who, based on the combined risk of the markers, is at significant combined risk of developing MI. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Association results for SNPs showing association to Myoardial Infarction (MI) and coronary artery disease (CAD). The columns indicate 
               
               
                 (1) chromosome, (2) position in NCBI Build 34, (3) rs name of the SNP in question, (4), the associating allele, (5) frequency of the associating 
               
               
                 allele in controls, (6) the number of controls, (7), the p-value for association to MI, (8) the Relative Risk of association to MI, (9) the frequency 
               
               
                 of the associating allele in MI patients, (10) the number of MI patients, (11) the p-value of association to CAD, (12) the Relative Risk of 
               
               
                 association to CAD, (13) the frequency of the associating allele in CAD patients, (14) the number of CAD patients. The table is sorted on p- 
               
               
                 values for association to MI. 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 chr 
                 position b34 
                 rs-name 
                 allele 
                 f(con) 
                 N(con) 
                 p(MI) 
                 RR(MI) 
                 f(MI) 
                 N(MI) 
                 p(CAD) 
                 rr(CAD) 
                 f(CAD) 
                 N(CAD) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 CX 
                 91765264 
                 rs2227165 
                 C 
                 0.897 
                 8178 
                 2.08E−07 
                 1.61 
                 0.934 
                 1068 
                 5.16E−05 
                 1.39 
                 0.924 
                 1276 
               
               
                 C12 
                 124441592 
                 rs12304836 
                 C 
                 0.141 
                 10541 
                 7.66E−06 
                 1.27 
                 0.173 
                 1689 
                 6.26E−06 
                 1.25 
                 0.171 
                 2020 
               
               
                 C11 
                 101370325 
                 rs11225090 
                 T 
                 0.969 
                 10513 
                 8.71E−06 
                 1.85 
                 0.983 
                 1646 
                 2.95E−05 
                 1.68 
                 0.981 
                 1979 
               
               
                 C05 
                 158504417 
                 rs7442701 
                 T 
                 0.174 
                 10629 
                 1.05E−05 
                 1.25 
                 0.208 
                 1699 
                 5.90E−05 
                 1.21 
                 0.202 
                 2033 
               
               
                 C12 
                 116419694 
                 rs816204 
                 A 
                 0.851 
                 10607 
                 1.10E−05 
                 1.29 
                 0.881 
                 1693 
                 4.70E−05 
                 1.25 
                 0.877 
                 2026 
               
               
                 C20 
                 4131671 
                 rs6076623 
                 T 
                 0.364 
                 10632 
                 1.20E−05 
                 1.19 
                 0.406 
                 1700 
                 2.40E−06 
                 1.19 
                 0.406 
                 2034 
               
               
                 C17 
                 17995010 
                 rs4925125 
                 T 
                 0.347 
                 10430 
                 1.55E−05 
                 1.19 
                 0.388 
                 1680 
                 3.40E−04 
                 1.15 
                 0.379 
                 2009 
               
               
                 C10 
                 90667504 
                 rs1412444 
                 A 
                 0.356 
                 10626 
                 1.60E−05 
                 1.19 
                 0.397 
                 1700 
                 2.38E−04 
                 1.15 
                 0.389 
                 2034 
               
               
                 C17 
                 18235585 
                 rs854787 
                 C 
                 0.398 
                 10568 
                 1.72E−05 
                 1.19 
                 0.44 
                 1689 
                 2.63E−05 
                 1.17 
                 0.436 
                 2023 
               
               
                 C10 
                 90675056 
                 rs2243547 
                 G 
                 0.339 
                 10200 
                 1.82E−05 
                 1.2 
                 0.38 
                 1642 
                 3.87E−04 
                 1.15 
                 0.37 
                 1970 
               
               
                 C08 
                 506479 
                 rs722782 
                 C 
                 0.888 
                 10607 
                 2.44E−05 
                 1.33 
                 0.914 
                 1668 
                 1.72E−04 
                 1.26 
                 0.909 
                 2002 
               
               
                 C11 
                 82905504 
                 rs2163612 
                 G 
                 0.476 
                 10625 
                 3.12E−05 
                 1.18 
                 0.517 
                 1698 
                 3.92E−05 
                 1.16 
                 0.513 
                 2032 
               
               
                 C01 
                 62766259 
                 rs12134779 
                 T 
                 0.29 
                 10634 
                 3.21E−05 
                 1.19 
                 0.327 
                 1699 
                 1.81E−04 
                 1.16 
                 0.321 
                 2033 
               
               
                 CX 
                 66228891 
                 rs7050085 
                 G 
                 0.909 
                 8267 
                 5.71E−05 
                 1.45 
                 0.936 
                 1103 
                 1.15E−04 
                 1.39 
                 0.933 
                 1316 
               
               
                 C07 
                 116846839 
                 rs12534186 
                 T 
                 0.079 
                 10631 
                 5.99E−05 
                 1.31 
                 0.102 
                 1699 
                 2.22E−04 
                 1.26 
                 0.098 
                 2033 
               
               
                 C05 
                 158510030 
                 rs7447732 
                 C 
                 0.316 
                 10635 
                 6.14E−05 
                 1.18 
                 0.353 
                 1700 
                 3.34E−04 
                 1.15 
                 0.347 
                 2034 
               
               
                 C07 
                 116800818 
                 rs2299445 
                 C 
                 0.079 
                 10630 
                 6.16E−05 
                 1.31 
                 0.101 
                 1699 
                 2.21E−04 
                 1.27 
                 0.098 
                 2033 
               
               
                 C07 
                 116800818 
                 rs2299445 
                 C 
                 0.079 
                 10630 
                 6.16E−05 
                 1.31 
                 0.101 
                 1699 
                 2.21E−04 
                 1.27 
                 0.098 
                 2033 
               
               
                 C19 
                 4229502 
                 rs4807567 
                 T 
                 0.419 
                 10586 
                 6.30E−05 
                 1.17 
                 0.458 
                 1699 
                 1.99E−04 
                 1.15 
                 0.453 
                 2033 
               
               
                 C13 
                 26936609 
                 rs4769613 
                 T 
                 0.467 
                 10633 
                 6.56E−05 
                 1.17 
                 0.506 
                 1699 
                 9.01E−06 
                 1.18 
                 0.507 
                 2033 
               
               
                 C05 
                 158671846 
                 rs4921437 
                 T 
                 0.212 
                 10594 
                 6.57E−05 
                 1.21 
                 0.245 
                 1691 
                 6.09E−04 
                 1.16 
                 0.238 
                 2023 
               
               
                 C10 
                 15439877 
                 rs12269612 
                 T 
                 0.398 
                 10634 
                 6.66E−05 
                 1.17 
                 0.437 
                 1700 
                 8.04E−04 
                 1.13 
                 0.428 
                 2034 
               
               
                 C12 
                 87995622 
                 rs1568383 
                 T 
                 0.097 
                 10635 
                 7.05E−05 
                 1.28 
                 0.121 
                 1700 
                 1.11E−04 
                 1.25 
                 0.119 
                 2034 
               
               
                 C21 
                 24038081 
                 rs2828495 
                 A 
                 0.211 
                 10635 
                 7.27E−05 
                 1.2 
                 0.244 
                 1700 
                 4.74E−05 
                 1.19 
                 0.242 
                 2034 
               
               
                 C10 
                 45239070 
                 rs2279434 
                 T 
                 0.065 
                 10634 
                 7.50E−05 
                 1.34 
                 0.085 
                 1700 
                 5.02E−04 
                 1.27 
                 0.081 
                 2033 
               
               
                 C02 
                 212588265 
                 rs12329252 
                 T 
                 0.676 
                 10635 
                 7.87E−05 
                 1.18 
                 0.712 
                 1700 
                 6.42E−04 
                 1.14 
                 0.705 
                 2034 
               
               
                 C03 
                 62420156 
                 rs9874646 
                 T 
                 0.709 
                 10634 
                 8.11E−05 
                 1.19 
                 0.744 
                 1700 
                 3.83E−04 
                 1.16 
                 0.738 
                 2034 
               
               
                 C04 
                 21568604 
                 rs4282162 
                 T 
                 0.528 
                 10633 
                 8.28E−05 
                 1.17 
                 0.567 
                 1700 
                 1.66E−04 
                 1.15 
                 0.563 
                 2034 
               
               
                 C03 
                 62402714 
                 rs1534725 
                 T 
                 0.782 
                 10627 
                 8.33E−05 
                 1.21 
                 0.814 
                 1699 
                 1.33E−04 
                 1.19 
                 0.811 
                 2033 
               
               
                 C03 
                 62402714 
                 rs1534725 
                 T 
                 0.782 
                 10627 
                 8.33E−05 
                 1.21 
                 0.814 
                 1699 
                 1.33E−04 
                 1.19 
                 0.811 
                 2033 
               
               
                 C09 
                 87419341 
                 rs3211683 
                 A 
                 0.088 
                 10635 
                 9.41E−05 
                 1.29 
                 0.111 
                 1700 
                 2.86E−04 
                 1.25 
                 0.108 
                 2034 
               
               
                 C11 
                 42877662 
                 rs1532096 
                 T 
                 0.861 
                 10635 
                 9.63E−05 
                 1.26 
                 0.887 
                 1700 
                 9.38E−05 
                 1.24 
                 0.885 
                 2034 
               
               
                 C22 
                 42582255 
                 rs738407 
                 A 
                 0.635 
                 10634 
                 9.70E−05 
                 1.18 
                 0.672 
                 1700 
                 5.67E−04 
                 1.14 
                 0.665 
                 2034 
               
               
                 C17 
                 17947855 
                 rs3183702 
                 T 
                 0.349 
                 10630 
                 9.76E−05 
                 1.17 
                 0.386 
                 1699 
                 1.01E−03 
                 1.13 
                 0.378 
                 2033 
               
               
                 C02 
                 39191408 
                 rs963731 
                 C 
                 0.951 
                 10365 
                 1.01E−04 
                 1.49 
                 0.966 
                 1651 
                 1.21E−04 
                 1.44 
                 0.965 
                 1978 
               
               
                 C09 
                 87414699 
                 rs3211650 
                 T 
                 0.089 
                 10634 
                 1.02E−04 
                 1.29 
                 0.111 
                 1700 
                 3.09E−04 
                 1.25 
                 0.108 
                 2034 
               
               
                 C06 
                 71671372 
                 rs7753765 
                 A 
                 0.144 
                 10633 
                 1.03E−04 
                 1.23 
                 0.172 
                 1700 
                 2.32E−04 
                 1.2 
                 0.169 
                 2034 
               
               
                 C01 
                 30378256 
                 rs593993 
                 C 
                 0.834 
                 10626 
                 1.09E−04 
                 1.24 
                 0.862 
                 1697 
                 7.25E−05 
                 1.23 
                 0.86 
                 2031 
               
               
                 C11 
                 17756131 
                 rs7946133 
                 T 
                 0.915 
                 10540 
                 1.12E−04 
                 1.35 
                 0.936 
                 1641 
                 1.43E−04 
                 1.31 
                 0.934 
                 1968 
               
               
                 C02 
                 212605929 
                 rs17406681 
                 T 
                 0.275 
                 10635 
                 1.13E−04 
                 1.18 
                 0.31 
                 1700 
                 3.42E−04 
                 1.15 
                 0.305 
                 2034 
               
               
                 C02 
                 212605929 
                 rs17406681 
                 T 
                 0.275 
                 10635 
                 1.13E−04 
                 1.18 
                 0.31 
                 1700 
                 3.42E−04 
                 1.15 
                 0.305 
                 2034 
               
               
                 C03 
                 14276852 
                 rs6772823 
                 G 
                 0.276 
                 10580 
                 1.18E−04 
                 1.18 
                 0.31 
                 1675 
                 1.98E−04 
                 1.16 
                 0.307 
                 2008 
               
               
                 C17 
                 17934326 
                 rs9902941 
                 C 
                 0.349 
                 10634 
                 1.25E−04 
                 1.17 
                 0.385 
                 1700 
                 1.18E−03 
                 1.13 
                 0.377 
                 2034 
               
               
                 C02 
                 123847245 
                 rs1395930 
                 T 
                 0.494 
                 10633 
                 1.25E−04 
                 1.16 
                 0.532 
                 1698 
                 3.18E−05 
                 1.16 
                 0.532 
                 2032 
               
               
                 C05 
                 158647626 
                 rs254850 
                 T 
                 0.215 
                 10635 
                 1.29E−04 
                 1.19 
                 0.247 
                 1700 
                 1.30E−03 
                 1.15 
                 0.24 
                 2034 
               
               
                 C03 
                 170405740 
                 rs756644 
                 A 
                 0.431 
                 10633 
                 1.30E−04 
                 1.16 
                 0.468 
                 1700 
                 1.56E−03 
                 1.12 
                 0.459 
                 2034 
               
               
                 C12 
                 47223943 
                 rs12581026 
                 C 
                 0.046 
                 10634 
                 1.33E−04 
                 1.39 
                 0.063 
                 1700 
                 3.67E−03 
                 1.27 
                 0.058 
                 2034 
               
               
                 C17 
                 17849989 
                 rs4925108 
                 C 
                 0.392 
                 10623 
                 1.35E−04 
                 1.16 
                 0.429 
                 1700 
                 4.28E−04 
                 1.14 
                 0.424 
                 2034 
               
               
                 C17 
                 17849989 
                 rs4925108 
                 C 
                 0.392 
                 10623 
                 1.35E−04 
                 1.16 
                 0.429 
                 1700 
                 4.28E−04 
                 1.14 
                 0.424 
                 2034 
               
               
                 C12 
                 95967869 
                 rs11108788 
                 G 
                 0.032 
                 10618 
                 1.38E−04 
                 1.47 
                 0.046 
                 1698 
                 3.43E−04 
                 1.4 
                 0.044 
                 2032 
               
               
                 C01 
                 53740224 
                 rs2294512 
                 G 
                 0.682 
                 10635 
                 1.41E−04 
                 1.18 
                 0.716 
                 1700 
                 1.47E−03 
                 1.13 
                 0.708 
                 2034 
               
               
                 C05 
                 102457857 
                 rs9327877 
                 T 
                 0.19 
                 10634 
                 1.45E−04 
                 1.2 
                 0.22 
                 1700 
                 2.47E−04 
                 1.18 
                 0.217 
                 2034 
               
               
                 C04 
                 21549446 
                 rs10516402 
                 C 
                 0.504 
                 10633 
                 1.46E−04 
                 1.16 
                 0.541 
                 1700 
                 2.09E−04 
                 1.15 
                 0.538 
                 2034 
               
               
                 C04 
                 21549446 
                 rs10516402 
                 C 
                 0.504 
                 10633 
                 1.46E−04 
                 1.16 
                 0.541 
                 1700 
                 2.09E−04 
                 1.15 
                 0.538 
                 2034 
               
               
                 C20 
                 15053882 
                 rs411944 
                 G 
                 0.645 
                 10632 
                 1.47E−04 
                 1.17 
                 0.68 
                 1700 
                 1.22E−03 
                 1.13 
                 0.673 
                 2033 
               
               
                 C13 
                 42581715 
                 rs9525923 
                 A 
                 0.208 
                 10635 
                 1.56E−04 
                 1.19 
                 0.239 
                 1700 
                 5.62E−04 
                 1.16 
                 0.234 
                 2034 
               
               
                 C02 
                 176947426 
                 rs921083 
                 G 
                 0.776 
                 10633 
                 1.56E−04 
                 1.2 
                 0.806 
                 1700 
                 2.93E−04 
                 1.18 
                 0.803 
                 2034 
               
               
                 C05 
                 97515007 
                 rs950195 
                 G 
                 0.63 
                 10631 
                 1.65E−04 
                 1.17 
                 0.665 
                 1700 
                 5.67E−05 
                 1.17 
                 0.665 
                 2034 
               
               
                 C05 
                 6897773 
                 rs870347 
                 T 
                 0.924 
                 10635 
                 1.73E−04 
                 1.35 
                 0.942 
                 1700 
                 1.14E−03 
                 1.27 
                 0.939 
                 2034 
               
               
                 C14 
                 67308303 
                 rs8003722 
                 A 
                 0.102 
                 10634 
                 1.73E−04 
                 1.26 
                 0.126 
                 1700 
                 2.73E−04 
                 1.23 
                 0.123 
                 2034 
               
               
                 C05 
                 50867460 
                 rs6449708 
                 T 
                 0.452 
                 10611 
                 1.73E−04 
                 1.16 
                 0.489 
                 1693 
                 1.17E−03 
                 1.13 
                 0.482 
                 2027 
               
               
                 C05 
                 50867460 
                 rs6449708 
                 T 
                 0.452 
                 10611 
                 1.73E−04 
                 1.16 
                 0.489 
                 1693 
                 1.17E−03 
                 1.13 
                 0.482 
                 2027 
               
               
                 C06 
                 160872518 
                 rs11751605 
                 C 
                 0.11 
                 10632 
                 1.75E−04 
                 1.25 
                 0.134 
                 1700 
                 3.87E−04 
                 1.22 
                 0.131 
                 2033 
               
               
                 C02 
                 123861662 
                 rs2661006 
                 T 
                 0.493 
                 10623 
                 1.76E−04 
                 1.16 
                 0.529 
                 1696 
                 5.58E−05 
                 1.16 
                 0.529 
                 2030 
               
               
                 C13 
                 45452894 
                 rs7322927 
                 A 
                 0.125 
                 10635 
                 1.78E−04 
                 1.24 
                 0.151 
                 1700 
                 3.29E−03 
                 1.17 
                 0.144 
                 2034 
               
               
                 C05 
                 56215087 
                 rs832540 
                 C 
                 0.415 
                 10626 
                 1.81E−04 
                 1.16 
                 0.451 
                 1700 
                 3.23E−04 
                 1.14 
                 0.447 
                 2034 
               
               
                 C04 
                 166320428 
                 rs11723570 
                 C 
                 0.511 
                 10635 
                 1.92E−04 
                 1.16 
                 0.547 
                 1700 
                 1.49E−04 
                 1.15 
                 0.545 
                 2034 
               
               
                 C19 
                 17027981 
                 rs2278997 
                 T 
                 0.229 
                 10635 
                 1.93E−04 
                 1.19 
                 0.261 
                 1700 
                 8.49E−04 
                 1.15 
                 0.255 
                 2034 
               
               
                 C19 
                 17027981 
                 rs2278997 
                 T 
                 0.229 
                 10635 
                 1.93E−04 
                 1.19 
                 0.261 
                 1700 
                 8.49E−04 
                 1.15 
                 0.255 
                 2034 
               
               
                 C16 
                 73532441 
                 rs12927636 
                 G 
                 0.105 
                 10635 
                 1.94E−04 
                 1.25 
                 0.129 
                 1700 
                 7.63E−04 
                 1.21 
                 0.125 
                 2034 
               
               
                 C11 
                 1371919 
                 rs7944761 
                 T 
                 0.526 
                 10631 
                 2.04E−04 
                 1.16 
                 0.563 
                 1700 
                 8.52E−04 
                 1.13 
                 0.557 
                 2034 
               
               
                 C07 
                 116887417 
                 rs975722 
                 G 
                 0.389 
                 10635 
                 2.05E−04 
                 1.16 
                 0.425 
                 1700 
                 3.18E−04 
                 1.14 
                 0.421 
                 2034 
               
               
                 C07 
                 116887417 
                 rs975722 
                 G 
                 0.389 
                 10635 
                 2.05E−04 
                 1.16 
                 0.425 
                 1700 
                 3.18E−04 
                 1.14 
                 0.421 
                 2034 
               
               
                 C17 
                 18035257 
                 rs6502622 
                 G 
                 0.359 
                 10635 
                 2.07E−04 
                 1.16 
                 0.395 
                 1700 
                 2.81E−03 
                 1.12 
                 0.386 
                 2034 
               
               
                 C02 
                 76284921 
                 rs443713 
                 G 
                 0.394 
                 10635 
                 2.09E−04 
                 1.16 
                 0.43 
                 1700 
                 1.77E−04 
                 1.15 
                 0.428 
                 2034 
               
               
                 C09 
                 16319537 
                 rs1888955 
                 A 
                 0.742 
                 10632 
                 2.19E−04 
                 1.19 
                 0.774 
                 1700 
                 8.61E−04 
                 1.15 
                 0.768 
                 2034 
               
               
                 C09 
                 16324761 
                 rs12683609 
                 A 
                 0.571 
                 10635 
                 2.20E−04 
                 1.16 
                 0.607 
                 1699 
                 4.83E−04 
                 1.14 
                 0.602 
                 2033 
               
               
                 C05 
                 167501721 
                 rs7736530 
                 G 
                 0.798 
                 10634 
                 2.20E−04 
                 1.21 
                 0.826 
                 1700 
                 2.77E−04 
                 1.19 
                 0.824 
                 2034 
               
               
                 C15 
                 24283869 
                 rs4572353 
                 T 
                 0.492 
                 10632 
                 2.25E−04 
                 1.16 
                 0.528 
                 1700 
                 4.64E−04 
                 1.14 
                 0.524 
                 2034 
               
               
                 C07 
                 116792948 
                 rs213977 
                 G 
                 0.409 
                 10633 
                 2.28E−04 
                 1.16 
                 0.445 
                 1700 
                 3.73E−04 
                 1.14 
                 0.441 
                 2034 
               
               
                 C02 
                 76346853 
                 rs1595968 
                 T 
                 0.394 
                 10622 
                 2.29E−04 
                 1.16 
                 0.43 
                 1695 
                 1.92E−04 
                 1.15 
                 0.428 
                 2029 
               
               
                 C01 
                 20544933 
                 rs12724604 
                 A 
                 0.036 
                 10634 
                 2.35E−04 
                 1.42 
                 0.051 
                 1700 
                 5.31E−05 
                 1.43 
                 0.051 
                 2034 
               
               
                 C04 
                 21483069 
                 rs1827591 
                 G 
                 0.535 
                 10635 
                 2.41E−04 
                 1.16 
                 0.571 
                 1700 
                 2.98E−04 
                 1.14 
                 0.568 
                 2034 
               
               
                 C01 
                 148957002 
                 rs12066445 
                 A 
                 0.299 
                 10635 
                 2.47E−04 
                 1.17 
                 0.332 
                 1700 
                 1.08E−03 
                 1.14 
                 0.326 
                 2034 
               
               
                 C17 
                 9590955 
                 rs3891720 
                 C 
                 0.869 
                 10613 
                 2.47E−04 
                 1.25 
                 0.893 
                 1698 
                 4.95E−04 
                 1.22 
                 0.89 
                 2032 
               
               
                 C17 
                 17943470 
                 rs4925119 
                 A 
                 0.347 
                 10615 
                 2.54E−04 
                 1.16 
                 0.381 
                 1696 
                 2.24E−03 
                 1.12 
                 0.373 
                 2029 
               
               
                 C08 
                 144065203 
                 rs7844961 
                 T 
                 0.09 
                 10635 
                 2.61E−04 
                 1.27 
                 0.112 
                 1700 
                 1.82E−03 
                 1.21 
                 0.107 
                 2034 
               
               
                 C01 
                 57254228 
                 rs2991515 
                 T 
                 0.479 
                 10635 
                 2.67E−04 
                 1.15 
                 0.515 
                 1700 
                 2.39E−05 
                 1.17 
                 0.518 
                 2034 
               
               
                 C20 
                 4150948 
                 rs1741315 
                 A 
                 0.483 
                 10633 
                 2.68E−04 
                 1.15 
                 0.519 
                 1700 
                 5.86E−04 
                 1.13 
                 0.514 
                 2034 
               
               
                 C20 
                 4150948 
                 rs1741315 
                 A 
                 0.483 
                 10633 
                 2.68E−04 
                 1.15 
                 0.519 
                 1700 
                 5.86E−04 
                 1.13 
                 0.514 
                 2034 
               
               
                 C09 
                 132592188 
                 rs4917341 
                 C 
                 0.481 
                 10587 
                 2.69E−04 
                 1.15 
                 0.516 
                 1697 
                 1.12E−03 
                 1.13 
                 0.51 
                 2029 
               
               
                 C08 
                 28215758 
                 rs4732849 
                 T 
                 0.273 
                 10635 
                 2.70E−04 
                 1.17 
                 0.306 
                 1700 
                 1.05E−02 
                 1.11 
                 0.294 
                 2034 
               
               
                 C20 
                 47199260 
                 rs981303 
                 A 
                 0.929 
                 10623 
                 2.73E−04 
                 1.35 
                 0.946 
                 1696 
                 1.53E−05 
                 1.4 
                 0.948 
                 2029 
               
               
                 C10 
                 84830992 
                 rs7921473 
                 G 
                 0.815 
                 10635 
                 2.77E−04 
                 1.21 
                 0.842 
                 1700 
                 3.79E−05 
                 1.22 
                 0.844 
                 2034 
               
               
                 C15 
                 43779321 
                 rs11630033 
                 C 
                 0.9 
                 10606 
                 2.77E−04 
                 1.29 
                 0.92 
                 1694 
                 3.81E−04 
                 1.26 
                 0.918 
                 2028 
               
               
                 C20 
                 13686900 
                 rs2026058 
                 T 
                 0.764 
                 10634 
                 2.77E−04 
                 1.19 
                 0.794 
                 1700 
                 3.63E−03 
                 1.14 
                 0.786 
                 2034 
               
               
                 C21 
                 16738666 
                 rs1349227 
                 T 
                 0.238 
                 10635 
                 2.77E−04 
                 1.18 
                 0.269 
                 1700 
                 4.65E−04 
                 1.16 
                 0.266 
                 2034 
               
               
                 C07 
                 116579323 
                 rs1029396 
                 G 
                 0.069 
                 10634 
                 2.78E−04 
                 1.3 
                 0.088 
                 1700 
                 2.26E−04 
                 1.28 
                 0.087 
                 2034 
               
               
                 C11 
                 7588325 
                 rs12292613 
                 T 
                 0.892 
                 10509 
                 2.88E−04 
                 1.28 
                 0.913 
                 1670 
                 3.35E−03 
                 1.2 
                 0.908 
                 2003 
               
               
                 C08 
                 70812569 
                 rs3829049 
                 G 
                 0.708 
                 10635 
                 2.91E−04 
                 1.17 
                 0.74 
                 1700 
                 5.19E−04 
                 1.15 
                 0.737 
                 2034 
               
               
                 C03 
                 25122677 
                 rs6763490 
                 C 
                 0.6 
                 10635 
                 2.94E−04 
                 1.16 
                 0.635 
                 1700 
                 7.39E−04 
                 1.14 
                 0.63 
                 2034 
               
               
                 C17 
                 17911836 
                 rs4925114 
                 A 
                 0.359 
                 10615 
                 2.97E−04 
                 1.16 
                 0.393 
                 1697 
                 1.89E−03 
                 1.12 
                 0.386 
                 2031 
               
               
                 C01 
                 19443039 
                 rs7535952 
                 A 
                 0.717 
                 10510 
                 2.99E−04 
                 1.18 
                 0.749 
                 1660 
                 3.29E−03 
                 1.13 
                 0.741 
                 1990 
               
               
                 C07 
                 46273364 
                 rs10243723 
                 G 
                 0.97 
                 10628 
                 3.04E−04 
                 1.61 
                 0.981 
                 1699 
                 1.27E−03 
                 1.47 
                 0.979 
                 2033 
               
               
                 C08 
                 18243855 
                 rs7006687 
                 T 
                 0.575 
                 10632 
                 3.05E−04 
                 1.16 
                 0.61 
                 1698 
                 7.18E−05 
                 1.16 
                 0.61 
                 2032 
               
               
                 C16 
                 61289938 
                 rs12924635 
                 G 
                 0.389 
                 10380 
                 3.06E−04 
                 1.16 
                 0.425 
                 1624 
                 3.29E−03 
                 1.12 
                 0.416 
                 1953 
               
               
                 C04 
                 10479642 
                 rs4697653 
                 G 
                 0.526 
                 10604 
                 3.08E−04 
                 1.15 
                 0.562 
                 1699 
                 8.82E−04 
                 1.13 
                 0.556 
                 2032 
               
               
                 C12 
                 112489807 
                 rs249047 
                 A 
                 0.614 
                 10634 
                 3.11E−04 
                 1.16 
                 0.648 
                 1700 
                 3.87E−03 
                 1.12 
                 0.639 
                 2034 
               
               
                 C07 
                 67324200 
                 rs12540706 
                 G 
                 0.311 
                 10634 
                 3.15E−04 
                 1.16 
                 0.344 
                 1700 
                 2.70E−03 
                 1.12 
                 0.337 
                 2034 
               
               
                 C10 
                 26191683 
                 rs7086207 
                 G 
                 0.404 
                 10625 
                 3.17E−04 
                 1.15 
                 0.439 
                 1699 
                 5.10E−04 
                 1.14 
                 0.435 
                 2033 
               
               
                 C05 
                 40281304 
                 rs13165359 
                 G 
                 0.877 
                 10634 
                 3.19E−04 
                 1.26 
                 0.899 
                 1700 
                 2.77E−03 
                 1.19 
                 0.894 
                 2034 
               
               
                 C05 
                 50777478 
                 rs10038238 
                 A 
                 0.567 
                 10634 
                 3.20E−04 
                 1.15 
                 0.602 
                 1699 
                 1.41E−03 
                 1.13 
                 0.596 
                 2033 
               
               
                 C01 
                 65319795 
                 rs2025805 
                 C 
                 0.565 
                 10634 
                 3.25E−04 
                 1.15 
                 0.6 
                 1700 
                 3.31E−04 
                 1.14 
                 0.597 
                 2034 
               
               
                 C17 
                 18204411 
                 rs854813 
                 C 
                 0.387 
                 10632 
                 3.25E−04 
                 1.15 
                 0.422 
                 1700 
                 6.90E−04 
                 1.13 
                 0.417 
                 2034 
               
               
                 C04 
                 21576609 
                 rs4377576 
                 C 
                 0.54 
                 10634 
                 3.25E−04 
                 1.15 
                 0.575 
                 1700 
                 5.32E−04 
                 1.14 
                 0.572 
                 2034 
               
               
                 C04 
                 21576609 
                 rs4377576 
                 C 
                 0.54 
                 10634 
                 3.25E−04 
                 1.15 
                 0.575 
                 1700 
                 5.32E−04 
                 1.14 
                 0.572 
                 2034 
               
               
                 C12 
                 65789635 
                 rs1465026 
                 G 
                 0.832 
                 10632 
                 3.27E−04 
                 1.22 
                 0.858 
                 1700 
                 8.82E−05 
                 1.22 
                 0.858 
                 2034 
               
               
                 C18 
                 2609280 
                 rs4271662 
                 C 
                 0.58 
                 10594 
                 3.34E−04 
                 1.16 
                 0.615 
                 1695 
                 9.97E−04 
                 1.13 
                 0.61 
                 2026 
               
               
                 C01 
                 150696580 
                 rs4845552 
                 G 
                 0.125 
                 10588 
                 3.40E−04 
                 1.23 
                 0.149 
                 1698 
                 2.40E−04 
                 1.21 
                 0.148 
                 2030 
               
               
                 C15 
                 24926452 
                 rs2110209 
                 A 
                 0.047 
                 10635 
                 3.42E−04 
                 1.36 
                 0.062 
                 1700 
                 9.53E−04 
                 1.3 
                 0.06 
                 2034 
               
               
                 C03 
                 170400106 
                 rs1430435 
                 G 
                 0.503 
                 10634 
                 3.44E−04 
                 1.15 
                 0.538 
                 1700 
                 2.59E−03 
                 1.12 
                 0.53 
                 2034 
               
               
                 C06 
                 72208904 
                 rs182106 
                 T 
                 0.523 
                 10635 
                 3.50E−04 
                 1.15 
                 0.558 
                 1700 
                 8.17E−04 
                 1.13 
                 0.554 
                 2034 
               
               
                 C03 
                 145877192 
                 rs10935515 
                 C 
                 0.583 
                 10623 
                 3.51E−04 
                 1.15 
                 0.618 
                 1699 
                 6.10E−04 
                 1.14 
                 0.614 
                 2033 
               
               
                 C06 
                 72149930 
                 rs9360453 
                 G 
                 0.711 
                 10616 
                 3.57E−04 
                 1.17 
                 0.742 
                 1697 
                 4.11E−04 
                 1.16 
                 0.74 
                 2030 
               
               
                 C05 
                 115427457 
                 rs17138668 
                 C 
                 0.947 
                 10634 
                 3.60E−04 
                 1.41 
                 0.962 
                 1700 
                 1.06E−03 
                 1.34 
                 0.96 
                 2034 
               
               
                 CX 
                 91547326 
                 rs6615536 
                 G 
                 0.987 
                 8272 
                 3.62E−04 
                 2.85 
                 0.995 
                 1103 
                 1.19E−04 
                 2.84 
                 0.995 
                 1316 
               
               
                 C03 
                 194770024 
                 rs883279 
                 C 
                 0.905 
                 10632 
                 3.63E−04 
                 1.29 
                 0.925 
                 1699 
                 1.46E−04 
                 1.29 
                 0.925 
                 2033 
               
               
                 C07 
                 116680904 
                 rs2283054 
                 A 
                 0.069 
                 10634 
                 3.73E−04 
                 1.3 
                 0.087 
                 1699 
                 3.39E−04 
                 1.27 
                 0.086 
                 2033 
               
               
                 C06 
                 136340016 
                 rs9376173 
                 A 
                 0.629 
                 10613 
                 3.74E−04 
                 1.16 
                 0.663 
                 1692 
                 1.42E−03 
                 1.13 
                 0.657 
                 2026 
               
               
                 C20 
                 4152600 
                 rs1741318 
                 A 
                 0.447 
                 10633 
                 3.75E−04 
                 1.15 
                 0.482 
                 1700 
                 1.07E−03 
                 1.13 
                 0.477 
                 2034 
               
               
                 C20 
                 4152600 
                 rs1741318 
                 A 
                 0.447 
                 10633 
                 3.75E−04 
                 1.15 
                 0.482 
                 1700 
                 1.07E−03 
                 1.13 
                 0.477 
                 2034 
               
               
                 C12 
                 47206273 
                 rs12425518 
                 A 
                 0.043 
                 10611 
                 3.78E−04 
                 1.37 
                 0.058 
                 1697 
                 9.36E−03 
                 1.25 
                 0.053 
                 2029 
               
               
                 C10 
                 8196155 
                 rs541045 
                 C 
                 0.431 
                 10501 
                 3.79E−04 
                 1.15 
                 0.466 
                 1659 
                 1.79E−03 
                 1.12 
                 0.459 
                 1992 
               
               
                 C01 
                 20789662 
                 rs12741305 
                 C 
                 0.036 
                 10635 
                 3.85E−04 
                 1.4 
                 0.05 
                 1698 
                 1.09E−04 
                 1.41 
                 0.05 
                 2031 
               
               
                 C07 
                 116688223 
                 rs2237721 
                 C 
                 0.069 
                 10634 
                 3.85E−04 
                 1.29 
                 0.087 
                 1700 
                 3.50E−04 
                 1.27 
                 0.086 
                 2034 
               
               
                 C08 
                 5498753 
                 rs10503316 
                 C 
                 0.776 
                 10635 
                 3.87E−04 
                 1.19 
                 0.804 
                 1700 
                 2.83E−03 
                 1.14 
                 0.798 
                 2034 
               
               
                 C05 
                 119516035 
                 rs7721883 
                 T 
                 0.461 
                 10597 
                 3.89E−04 
                 1.15 
                 0.496 
                 1698 
                 7.26E−03 
                 1.1 
                 0.486 
                 2032 
               
               
                 C02 
                 135122883 
                 rs2139311 
                 C 
                 0.594 
                 10622 
                 3.90E−04 
                 1.15 
                 0.628 
                 1699 
                 3.72E−04 
                 1.14 
                 0.626 
                 2033 
               
               
                 C01 
                 113676295 
                 rs2476601 
                 A 
                 0.13 
                 10633 
                 3.93E−04 
                 1.22 
                 0.154 
                 1700 
                 2.39E−04 
                 1.21 
                 0.153 
                 2034 
               
               
                 C18 
                 53271813 
                 rs634285 
                 G 
                 0.913 
                 10634 
                 3.98E−04 
                 1.3 
                 0.931 
                 1700 
                 3.28E−03 
                 1.22 
                 0.927 
                 2034 
               
               
                 C14 
                 99695081 
                 rs17776453 
                 G 
                 0.951 
                 10633 
                 4.00E−04 
                 1.43 
                 0.966 
                 1699 
                 2.30E−04 
                 1.41 
                 0.965 
                 2033 
               
               
                 C05 
                 56242295 
                 rs252890 
                 A 
                 0.425 
                 10632 
                 4.02E−04 
                 1.15 
                 0.459 
                 1699 
                 5.18E−04 
                 1.14 
                 0.456 
                 2033 
               
               
                 C01 
                 40523163 
                 rs7520394 
                 T 
                 0.651 
                 10619 
                 4.13E−04 
                 1.16 
                 0.684 
                 1698 
                 6.36E−03 
                 1.11 
                 0.674 
                 2032 
               
               
                 C22 
                 44896799 
                 rs739164 
                 A 
                 0.894 
                 10523 
                 4.21E−04 
                 1.28 
                 0.915 
                 1645 
                 5.43E−04 
                 1.25 
                 0.913 
                 1978 
               
               
                 C10 
                 90674890 
                 rs2243548 
                 A 
                 0.509 
                 10625 
                 4.25E−04 
                 1.15 
                 0.544 
                 1698 
                 5.06E−03 
                 1.11 
                 0.534 
                 2031 
               
               
                 C10 
                 90674890 
                 rs2243548 
                 A 
                 0.509 
                 10625 
                 4.25E−04 
                 1.15 
                 0.544 
                 1698 
                 5.06E−03 
                 1.11 
                 0.534 
                 2031 
               
               
                 CX 
                 108301033 
                 rs3788769 
                 C 
                 0.445 
                 8210 
                 4.25E−04 
                 1.19 
                 0.487 
                 1095 
                 1.26E−03 
                 1.16 
                 0.481 
                 1307 
               
               
                 C22 
                 34873996 
                 rs7364143 
                 T 
                 0.28 
                 10592 
                 4.25E−04 
                 1.16 
                 0.311 
                 1696 
                 6.90E−04 
                 1.15 
                 0.308 
                 2030 
               
               
                 C03 
                 191533619 
                 rs9864293 
                 C 
                 0.385 
                 10632 
                 4.43E−04 
                 1.15 
                 0.419 
                 1700 
                 9.88E−04 
                 1.13 
                 0.415 
                 2033 
               
               
                 C07 
                 102617539 
                 rs2270019 
                 G 
                 0.165 
                 10614 
                 4.44E−04 
                 1.2 
                 0.192 
                 1697 
                 2.59E−04 
                 1.19 
                 0.191 
                 2031 
               
               
                 C20 
                 15229479 
                 rs6034134 
                 G 
                 0.594 
                 10634 
                 4.48E−04 
                 1.15 
                 0.628 
                 1700 
                 1.86E−03 
                 1.12 
                 0.622 
                 2034 
               
               
                 C05 
                 153269681 
                 rs1461236 
                 T 
                 0.855 
                 10614 
                 4.49E−04 
                 1.23 
                 0.879 
                 1689 
                 4.26E−03 
                 1.17 
                 0.873 
                 2023 
               
               
                 C11 
                 92904904 
                 rs2658801 
                 A 
                 0.269 
                 10634 
                 4.49E−04 
                 1.16 
                 0.3 
                 1700 
                 1.76E−04 
                 1.16 
                 0.299 
                 2034 
               
               
                 C17 
                 10435400 
                 rs9903582 
                 C 
                 0.745 
                 10634 
                 4.53E−04 
                 1.18 
                 0.775 
                 1700 
                 1.92E−03 
                 1.14 
                 0.769 
                 2034 
               
               
                 C15 
                 84295353 
                 rs4887480 
                 G 
                 0.769 
                 10629 
                 4.55E−04 
                 1.18 
                 0.798 
                 1700 
                 3.82E−03 
                 1.14 
                 0.791 
                 2034 
               
               
                 C17 
                 17860913 
                 rs752579 
                 G 
                 0.388 
                 10632 
                 4.57E−04 
                 1.15 
                 0.421 
                 1700 
                 1.55E−03 
                 1.12 
                 0.416 
                 2034 
               
               
                 C17 
                 17860913 
                 rs752579 
                 G 
                 0.388 
                 10632 
                 4.57E−04 
                 1.15 
                 0.421 
                 1700 
                 1.55E−03 
                 1.12 
                 0.416 
                 2034 
               
               
                 C14 
                 92765567 
                 rs10498639 
                 A 
                 0.423 
                 10633 
                 4.57E−04 
                 1.15 
                 0.457 
                 1700 
                 1.35E−03 
                 1.12 
                 0.452 
                 2034 
               
               
                 C20 
                 284362 
                 rs723477 
                 T 
                 0.74 
                 10613 
                 4.57E−04 
                 1.18 
                 0.77 
                 1694 
                 2.16E−03 
                 1.14 
                 0.764 
                 2027 
               
               
                 C05 
                 10009076 
                 rs16883905 
                 T 
                 0.111 
                 10635 
                 4.59E−04 
                 1.23 
                 0.134 
                 1700 
                 7.81E−04 
                 1.21 
                 0.131 
                 2034 
               
               
                 C06 
                 106193116 
                 rs845851 
                 A 
                 0.766 
                 10631 
                 4.60E−04 
                 1.18 
                 0.794 
                 1700 
                 2.14E−03 
                 1.14 
                 0.789 
                 2034 
               
               
                 C08 
                 143178480 
                 rs9644545 
                 T 
                 0.476 
                 10632 
                 4.61E−04 
                 1.15 
                 0.511 
                 1700 
                 4.98E−03 
                 1.11 
                 0.502 
                 2034 
               
               
                 C12 
                 9180220 
                 rs2160424 
                 G 
                 0.557 
                 10608 
                 4.62E−04 
                 1.15 
                 0.591 
                 1690 
                 4.58E−03 
                 1.11 
                 0.583 
                 2022 
               
               
                 C12 
                 19360345 
                 rs10743315 
                 G 
                 0.878 
                 10613 
                 4.84E−04 
                 1.25 
                 0.9 
                 1694 
                 1.58E−03 
                 1.2 
                 0.896 
                 2028 
               
               
                 C05 
                 56298431 
                 rs2408654 
                 C 
                 0.273 
                 10635 
                 4.84E−04 
                 1.16 
                 0.304 
                 1700 
                 4.74E−04 
                 1.15 
                 0.302 
                 2034 
               
               
                 C05 
                 167473287 
                 rs7705176 
                 G 
                 0.781 
                 10635 
                 4.87E−04 
                 1.19 
                 0.809 
                 1700 
                 1.68E−03 
                 1.15 
                 0.805 
                 2034 
               
               
                 C03 
                 62396924 
                 rs1997366 
                 C 
                 0.792 
                 10623 
                 4.88E−04 
                 1.19 
                 0.82 
                 1700 
                 9.05E−04 
                 1.17 
                 0.817 
                 2033 
               
               
                 C03 
                 62396924 
                 rs1997366 
                 C 
                 0.792 
                 10623 
                 4.88E−04 
                 1.19 
                 0.82 
                 1700 
                 9.05E−04 
                 1.17 
                 0.817 
                 2033 
               
               
                 C04 
                 21494114 
                 rs6448072 
                 C 
                 0.655 
                 10634 
                 4.89E−04 
                 1.16 
                 0.688 
                 1700 
                 1.95E−04 
                 1.16 
                 0.687 
                 2034 
               
               
                 C20 
                 49593462 
                 rs913673 
                 C 
                 0.539 
                 10624 
                 4.90E−04 
                 1.15 
                 0.574 
                 1700 
                 1.89E−03 
                 1.12 
                 0.568 
                 2034 
               
               
                 C10 
                 119318254 
                 rs1557227 
                 C 
                 0.855 
                 10635 
                 4.91E−04 
                 1.23 
                 0.879 
                 1700 
                 4.19E−04 
                 1.21 
                 0.877 
                 2034 
               
               
                 C05 
                 158541049 
                 rs270661 
                 A 
                 0.205 
                 10634 
                 4.93E−04 
                 1.18 
                 0.233 
                 1699 
                 3.06E−03 
                 1.14 
                 0.227 
                 2033 
               
               
                 C05 
                 158541049 
                 rs270661 
                 A 
                 0.205 
                 10634 
                 4.93E−04 
                 1.18 
                 0.233 
                 1699 
                 3.06E−03 
                 1.14 
                 0.227 
                 2033 
               
               
                 C06 
                 72209498 
                 rs199623 
                 A 
                 0.523 
                 10635 
                 4.98E−04 
                 1.15 
                 0.557 
                 1700 
                 1.17E−03 
                 1.13 
                 0.552 
                 2034 
               
               
                 C09 
                 134953713 
                 rs2385891 
                 A 
                 0.544 
                 10612 
                 4.98E−04 
                 1.15 
                 0.578 
                 1694 
                 2.79E−03 
                 1.12 
                 0.571 
                 2028 
               
               
                 C09 
                 16321304 
                 rs9407756 
                 G 
                 0.67 
                 10634 
                 5.13E−04 
                 1.16 
                 0.702 
                 1700 
                 3.35E−03 
                 1.12 
                 0.695 
                 2034 
               
               
                 C08 
                 1315247 
                 rs7386449 
                 A 
                 0.68 
                 10634 
                 5.29E−04 
                 1.16 
                 0.711 
                 1700 
                 7.10E−04 
                 1.14 
                 0.708 
                 2034 
               
               
                 C08 
                 1315247 
                 rs7386449 
                 A 
                 0.68 
                 10634 
                 5.29E−04 
                 1.16 
                 0.711 
                 1700 
                 7.10E−04 
                 1.14 
                 0.708 
                 2034 
               
               
                 C05 
                 178690232 
                 rs3756566 
                 G 
                 0.401 
                 10632 
                 5.32E−04 
                 1.15 
                 0.434 
                 1700 
                 3.57E−04 
                 1.14 
                 0.433 
                 2034 
               
               
                 C10 
                 84919047 
                 rs11198993 
                 A 
                 0.688 
                 10564 
                 5.37E−04 
                 1.16 
                 0.719 
                 1692 
                 1.05E−05 
                 1.19 
                 0.725 
                 2024 
               
               
                 C12 
                 65801361 
                 rs1526839 
                 G 
                 0.831 
                 10632 
                 5.39E−04 
                 1.21 
                 0.856 
                 1700 
                 1.32E−04 
                 1.21 
                 0.856 
                 2034 
               
               
                 C18 
                 58503179 
                 rs12458349 
                 G 
                 0.061 
                 10603 
                 5.50E−04 
                 1.3 
                 0.078 
                 1700 
                 1.46E−04 
                 1.31 
                 0.078 
                 2032 
               
               
                 C06 
                 106204603 
                 rs4946680 
                 T 
                 0.632 
                 10635 
                 5.50E−04 
                 1.15 
                 0.665 
                 1700 
                 1.76E−03 
                 1.13 
                 0.66 
                 2034 
               
               
                 C03 
                 124473843 
                 rs9847700 
                 G 
                 0.852 
                 10529 
                 5.53E−04 
                 1.23 
                 0.876 
                 1654 
                 9.60E−04 
                 1.2 
                 0.873 
                 1986 
               
               
                 C18 
                 56405620 
                 rs603119 
                 T 
                 0.386 
                 10606 
                 5.54E−04 
                 1.15 
                 0.419 
                 1699 
                 9.25E−05 
                 1.16 
                 0.421 
                 2032 
               
               
                 C06 
                 113938753 
                 rs4945955 
                 T 
                 0.092 
                 10614 
                 5.55E−04 
                 1.25 
                 0.112 
                 1697 
                 5.18E−04 
                 1.23 
                 0.111 
                 2031 
               
               
                 C05 
                 26932085 
                 rs1382932 
                 C 
                 0.68 
                 10635 
                 5.60E−04 
                 1.16 
                 0.711 
                 1700 
                 1.13E−03 
                 1.14 
                 0.707 
                 2034 
               
               
                 C05 
                 76583322 
                 rs974280 
                 G 
                 0.357 
                 10635 
                 5.63E−04 
                 1.15 
                 0.39 
                 1700 
                 1.34E−03 
                 1.13 
                 0.385 
                 2034 
               
               
                 C16 
                 19044749 
                 rs7500550 
                 G 
                 0.774 
                 10635 
                 5.63E−04 
                 1.18 
                 0.802 
                 1699 
                 1.97E−03 
                 1.15 
                 0.798 
                 2033 
               
               
                 C05 
                 56284090 
                 rs1445998 
                 A 
                 0.4 
                 10635 
                 5.67E−04 
                 1.15 
                 0.433 
                 1700 
                 5.78E−04 
                 1.14 
                 0.43 
                 2034 
               
               
                 C14 
                 48189298 
                 rs4898630 
                 A 
                 0.876 
                 10633 
                 5.71E−04 
                 1.24 
                 0.898 
                 1700 
                 9.58E−04 
                 1.21 
                 0.895 
                 2034 
               
               
                 C19 
                 34828875 
                 rs4805463 
                 G 
                 0.906 
                 10634 
                 5.72E−04 
                 1.28 
                 0.925 
                 1700 
                 1.08E−03 
                 1.24 
                 0.923 
                 2034 
               
               
                 C07 
                 28352068 
                 rs1976489 
                 G 
                 0.249 
                 10635 
                 5.77E−04 
                 1.17 
                 0.279 
                 1700 
                 2.15E−03 
                 1.14 
                 0.274 
                 2034 
               
               
                 C12 
                 19263624 
                 rs9805106 
                 G 
                 0.817 
                 10618 
                 5.79E−04 
                 1.2 
                 0.843 
                 1695 
                 7.98E−04 
                 1.18 
                 0.84 
                 2029 
               
               
                 C17 
                 17915667 
                 rs11868035 
                 A 
                 0.296 
                 10623 
                 5.79E−04 
                 1.16 
                 0.327 
                 1699 
                 5.61E−03 
                 1.12 
                 0.319 
                 2033 
               
               
                 C17 
                 17915667 
                 rs11868035 
                 A 
                 0.296 
                 10623 
                 5.79E−04 
                 1.16 
                 0.327 
                 1699 
                 5.61E−03 
                 1.12 
                 0.319 
                 2033 
               
               
                 C01 
                 209613176 
                 rs792446 
                 G 
                 0.611 
                 10634 
                 5.80E−04 
                 1.15 
                 0.644 
                 1700 
                 1.30E−02 
                 1.1 
                 0.633 
                 2033 
               
               
                 C13 
                 109862872 
                 rs1163852 
                 C 
                 0.714 
                 10635 
                 5.83E−04 
                 1.17 
                 0.744 
                 1700 
                 2.89E−04 
                 1.16 
                 0.743 
                 2034 
               
               
                 C03 
                 22619885 
                 rs1870480 
                 G 
                 0.38 
                 10635 
                 5.85E−04 
                 1.15 
                 0.413 
                 1700 
                 3.12E−04 
                 1.14 
                 0.412 
                 2034 
               
               
                 C15 
                 97226804 
                 rs2684790 
                 T 
                 0.146 
                 10634 
                 5.87E−04 
                 1.2 
                 0.17 
                 1700 
                 7.79E−04 
                 1.18 
                 0.168 
                 2034 
               
               
                 C14 
                 44542892 
                 rs1742655 
                 C 
                 0.884 
                 10635 
                 5.91E−04 
                 1.25 
                 0.905 
                 1700 
                 3.42E−03 
                 1.19 
                 0.901 
                 2034 
               
               
                 C12 
                 114213023 
                 rs1920947 
                 C 
                 0.812 
                 10635 
                 5.92E−04 
                 1.2 
                 0.838 
                 1700 
                 7.20E−03 
                 1.14 
                 0.831 
                 2034 
               
               
                 C01 
                 30387821 
                 rs12029866 
                 G 
                 0.771 
                 10634 
                 5.93E−04 
                 1.18 
                 0.799 
                 1700 
                 1.33E−04 
                 1.19 
                 0.8 
                 2034 
               
               
                 C11 
                 91095458 
                 rs2568712 
                 T 
                 0.385 
                 10599 
                 5.98E−04 
                 1.15 
                 0.418 
                 1699 
                 1.68E−03 
                 1.12 
                 0.413 
                 2031 
               
               
                 C01 
                 168129978 
                 rs11582943 
                 A 
                 0.94 
                 10619 
                 5.99E−04 
                 1.36 
                 0.955 
                 1693 
                 6.87E−04 
                 1.33 
                 0.954 
                 2027 
               
               
                 C01 
                 168129978 
                 rs11582943 
                 A 
                 0.94 
                 10619 
                 5.99E−04 
                 1.36 
                 0.955 
                 1693 
                 6.87E−04 
                 1.33 
                 0.954 
                 2027 
               
               
                 C02 
                 49219942 
                 rs3788982 
                 G 
                 0.871 
                 10635 
                 6.02E−04 
                 1.24 
                 0.893 
                 1700 
                 8.11E−05 
                 1.25 
                 0.894 
                 2034 
               
               
                 C10 
                 131670000 
                 rs639079 
                 G 
                 0.187 
                 10389 
                 6.03E−04 
                 1.18 
                 0.214 
                 1664 
                 7.05E−04 
                 1.17 
                 0.212 
                 1992 
               
               
                 C01 
                 76636957 
                 rs1566250 
                 G 
                 0.702 
                 10634 
                 6.13E−04 
                 1.16 
                 0.732 
                 1700 
                 1.98E−04 
                 1.16 
                 0.733 
                 2034 
               
               
                 C12 
                 87964674 
                 rs1401875 
                 T 
                 0.057 
                 10626 
                 6.13E−04 
                 1.31 
                 0.073 
                 1697 
                 1.83E−03 
                 1.26 
                 0.07 
                 2031 
               
               
                 C12 
                 87964674 
                 rs1401875 
                 T 
                 0.057 
                 10626 
                 6.13E−04 
                 1.31 
                 0.073 
                 1697 
                 1.83E−03 
                 1.26 
                 0.07 
                 2031 
               
               
                 C05 
                 158753477 
                 rs953861 
                 G 
                 0.16 
                 10632 
                 6.14E−04 
                 1.19 
                 0.185 
                 1700 
                 1.51E−02 
                 1.13 
                 0.176 
                 2034 
               
               
                 C01 
                 82599958 
                 rs12032817 
                 G 
                 0.371 
                 10635 
                 6.15E−04 
                 1.15 
                 0.404 
                 1700 
                 6.29E−03 
                 1.11 
                 0.396 
                 2034 
               
               
                 C03 
                 78544480 
                 rs2055707 
                 A 
                 0.418 
                 10603 
                 6.20E−04 
                 1.15 
                 0.451 
                 1699 
                 2.42E−03 
                 1.12 
                 0.445 
                 2033 
               
               
                 C19 
                 4231186 
                 rs10419363 
                 T 
                 0.299 
                 10610 
                 6.22E−04 
                 1.16 
                 0.331 
                 1695 
                 8.39E−04 
                 1.14 
                 0.328 
                 2028 
               
               
                 C02 
                 235330231 
                 rs12617590 
                 C 
                 0.199 
                 10624 
                 6.29E−04 
                 1.18 
                 0.227 
                 1700 
                 2.26E−03 
                 1.15 
                 0.222 
                 2034 
               
               
                 C04 
                 87398087 
                 rs2589506 
                 G 
                 0.451 
                 10632 
                 6.31E−04 
                 1.14 
                 0.485 
                 1700 
                 1.15E−04 
                 1.15 
                 0.486 
                 2034 
               
               
                 C10 
                 87792858 
                 rs3814614 
                 T 
                 0.501 
                 10628 
                 6.35E−04 
                 1.14 
                 0.535 
                 1700 
                 1.05E−03 
                 1.13 
                 0.531 
                 2034 
               
               
                 C04 
                 97290133 
                 rs10516987 
                 G 
                 0.797 
                 10598 
                 6.35E−04 
                 1.19 
                 0.824 
                 1691 
                 1.55E−03 
                 1.16 
                 0.82 
                 2023 
               
               
                 C13 
                 101108783 
                 rs1375719 
                 C 
                 0.499 
                 10634 
                 6.36E−04 
                 1.14 
                 0.532 
                 1700 
                 1.03E−02 
                 1.1 
                 0.522 
                 2034 
               
               
                 C17 
                 18231090 
                 rs854793 
                 A 
                 0.202 
                 10631 
                 6.36E−04 
                 1.18 
                 0.229 
                 1700 
                 1.59E−03 
                 1.15 
                 0.225 
                 2034 
               
               
                 C15 
                 76722261 
                 rs11072793 
                 G 
                 0.227 
                 10613 
                 6.38E−04 
                 1.17 
                 0.255 
                 1695 
                 1.52E−03 
                 1.14 
                 0.251 
                 2029 
               
               
                 C09 
                 8437732 
                 rs2890795 
                 T 
                 0.577 
                 10630 
                 6.38E−04 
                 1.15 
                 0.61 
                 1700 
                 1.20E−03 
                 1.13 
                 0.606 
                 2034 
               
               
                 C07 
                 67296404 
                 rs4527771 
                 A 
                 0.406 
                 10572 
                 6.43E−04 
                 1.15 
                 0.439 
                 1694 
                 8.45E−03 
                 1.1 
                 0.43 
                 2027 
               
               
                 C13 
                 66843127 
                 rs17070671 
                 T 
                 0.833 
                 10633 
                 6.44E−04 
                 1.21 
                 0.857 
                 1700 
                 9.00E−03 
                 1.14 
                 0.85 
                 2034 
               
               
                 C16 
                 73542120 
                 rs1038864 
                 C 
                 0.183 
                 10634 
                 6.45E−04 
                 1.18 
                 0.209 
                 1700 
                 4.45E−03 
                 1.14 
                 0.203 
                 2034 
               
               
                 C06 
                 25536933 
                 rs722086 
                 T 
                 0.856 
                 10166 
                 6.47E−04 
                 1.22 
                 0.879 
                 1687 
                 7.47E−03 
                 1.16 
                 0.873 
                 2015 
               
               
                 C08 
                 70811871 
                 rs4738034 
                 C 
                 0.701 
                 10635 
                 6.49E−04 
                 1.16 
                 0.731 
                 1700 
                 9.61E−04 
                 1.14 
                 0.728 
                 2034 
               
               
                 C18 
                 55095560 
                 rs657773 
                 C 
                 0.551 
                 10634 
                 6.57E−04 
                 1.15 
                 0.585 
                 1700 
                 1.04E−03 
                 1.13 
                 0.581 
                 2034 
               
               
                 C02 
                 134844429 
                 rs2321299 
                 C 
                 0.568 
                 10633 
                 6.58E−04 
                 1.15 
                 0.601 
                 1700 
                 3.50E−03 
                 1.11 
                 0.595 
                 2033 
               
               
                 C06 
                 149543409 
                 rs6570956 
                 T 
                 0.734 
                 10635 
                 6.61E−04 
                 1.17 
                 0.764 
                 1700 
                 6.82E−03 
                 1.12 
                 0.756 
                 2034 
               
               
                 C12 
                 116667030 
                 rs4767629 
                 T 
                 0.139 
                 10634 
                 6.61E−04 
                 1.2 
                 0.163 
                 1700 
                 5.33E−03 
                 1.15 
                 0.157 
                 2034 
               
               
                 C01 
                 80891035 
                 rs1030414 
                 G 
                 0.901 
                 10635 
                 6.73E−04 
                 1.27 
                 0.92 
                 1700 
                 3.45E−04 
                 1.26 
                 0.92 
                 2033 
               
               
                 C06 
                 69176005 
                 rs1565487 
                 A 
                 0.856 
                 10630 
                 6.74E−04 
                 1.22 
                 0.879 
                 1700 
                 2.07E−04 
                 1.22 
                 0.879 
                 2034 
               
               
                 C10 
                 123913719 
                 rs2239586 
                 T 
                 0.118 
                 10630 
                 6.75E−04 
                 1.22 
                 0.14 
                 1700 
                 2.95E−03 
                 1.18 
                 0.136 
                 2034 
               
               
                 C11 
                 122290366 
                 rs4936757 
                 C 
                 0.565 
                 10633 
                 6.76E−04 
                 1.15 
                 0.598 
                 1700 
                 3.91E−03 
                 1.11 
                 0.591 
                 2034 
               
               
                 C12 
                 22090132 
                 rs2955503 
                 A 
                 0.654 
                 10629 
                 6.82E−04 
                 1.15 
                 0.686 
                 1700 
                 2.41E−04 
                 1.15 
                 0.686 
                 2033 
               
               
                 C17 
                 52089014 
                 rs11656018 
                 C 
                 0.703 
                 10600 
                 6.84E−04 
                 1.16 
                 0.733 
                 1699 
                 8.06E−04 
                 1.15 
                 0.731 
                 2032 
               
               
                 C06 
                 159976575 
                 rs2758317 
                 C 
                 0.427 
                 10572 
                 6.86E−04 
                 1.14 
                 0.46 
                 1690 
                 6.67E−03 
                 1.11 
                 0.452 
                 2019 
               
               
                 C18 
                 43266738 
                 rs17734724 
                 G 
                 0.271 
                 10635 
                 6.87E−04 
                 1.16 
                 0.301 
                 1700 
                 3.27E−03 
                 1.13 
                 0.295 
                 2034 
               
               
                 C02 
                 19979982 
                 rs12467812 
                 G 
                 0.331 
                 10634 
                 6.88E−04 
                 1.15 
                 0.363 
                 1700 
                 2.30E−04 
                 1.15 
                 0.363 
                 2034 
               
               
                 C15 
                 51085506 
                 rs1156234 
                 G 
                 0.791 
                 10633 
                 6.91E−04 
                 1.18 
                 0.818 
                 1700 
                 5.59E−04 
                 1.17 
                 0.816 
                 2034 
               
               
                 C10 
                 123156230 
                 rs2936875 
                 T 
                 0.782 
                 10629 
                 6.92E−04 
                 1.18 
                 0.809 
                 1699 
                 4.42E−03 
                 1.14 
                 0.803 
                 2033 
               
               
                 C19 
                 58638423 
                 rs11668495 
                 C 
                 0.944 
                 10470 
                 7.08E−04 
                 1.38 
                 0.959 
                 1668 
                 1.43E−03 
                 1.32 
                 0.957 
                 1995 
               
               
                 C07 
                 136198861 
                 rs11761344 
                 T 
                 0.116 
                 10635 
                 7.12E−04 
                 1.22 
                 0.138 
                 1699 
                 8.84E−04 
                 1.2 
                 0.136 
                 2033 
               
               
                 C10 
                 84739213 
                 rs4617529 
                 G 
                 0.852 
                 10635 
                 7.15E−04 
                 1.22 
                 0.875 
                 1700 
                 6.68E−04 
                 1.2 
                 0.873 
                 2034 
               
               
                 C08 
                 139196618 
                 rs4909761 
                 T 
                 0.262 
                 10634 
                 7.20E−04 
                 1.16 
                 0.291 
                 1700 
                 2.65E−03 
                 1.13 
                 0.286 
                 2034 
               
               
                 C05 
                 94602573 
                 rs6556861 
                 G 
                 0.567 
                 10634 
                 7.24E−04 
                 1.14 
                 0.6 
                 1700 
                 2.99E−03 
                 1.12 
                 0.594 
                 2034 
               
               
                 C09 
                 132606652 
                 rs1930788 
                 C 
                 0.247 
                 10635 
                 7.27E−04 
                 1.16 
                 0.276 
                 1700 
                 4.10E−03 
                 1.13 
                 0.27 
                 2034 
               
               
                 C05 
                 157926810 
                 rs2964513 
                 A 
                 0.689 
                 10559 
                 7.29E−04 
                 1.16 
                 0.72 
                 1698 
                 3.01E−03 
                 1.13 
                 0.714 
                 2030 
               
               
                 C08 
                 5508780 
                 rs6991017 
                 T 
                 0.794 
                 10607 
                 7.30E−04 
                 1.19 
                 0.82 
                 1698 
                 5.36E−03 
                 1.14 
                 0.814 
                 2032 
               
               
                 C02 
                 135133800 
                 rs12473666 
                 T 
                 0.137 
                 10629 
                 7.31E−04 
                 1.2 
                 0.16 
                 1700 
                 2.94E−03 
                 1.17 
                 0.156 
                 2034 
               
               
                 C17 
                 18149041 
                 rs2955355 
                 C 
                 0.287 
                 10635 
                 7.35E−04 
                 1.16 
                 0.317 
                 1700 
                 3.19E−03 
                 1.12 
                 0.311 
                 2034 
               
               
                 C11 
                 44349237 
                 rs10838271 
                 C 
                 0.21 
                 10635 
                 7.42E−04 
                 1.17 
                 0.238 
                 1700 
                 3.32E−03 
                 1.14 
                 0.233 
                 2034 
               
               
                 C01 
                 238617451 
                 rs1341449 
                 A 
                 0.545 
                 10559 
                 7.44E−04 
                 1.14 
                 0.579 
                 1681 
                 1.15E−03 
                 1.13 
                 0.575 
                 2014 
               
               
                 C15 
                 34765965 
                 rs1901725 
                 T 
                 0.125 
                 10635 
                 7.47E−04 
                 1.21 
                 0.148 
                 1700 
                 3.63E−03 
                 1.17 
                 0.143 
                 2034 
               
               
                 C10 
                 87786571 
                 rs4933391 
                 A 
                 0.386 
                 10634 
                 7.50E−04 
                 1.14 
                 0.418 
                 1700 
                 1.30E−03 
                 1.13 
                 0.414 
                 2034 
               
               
                 C01 
                 80911800 
                 rs7531507 
                 G 
                 0.921 
                 10634 
                 7.52E−04 
                 1.3 
                 0.938 
                 1700 
                 3.18E−04 
                 1.3 
                 0.938 
                 2034 
               
               
                 C14 
                 57289229 
                 rs2069334 
                 A 
                 0.184 
                 10635 
                 7.54E−04 
                 1.18 
                 0.211 
                 1700 
                 6.14E−03 
                 1.13 
                 0.204 
                 2034 
               
               
                 C02 
                 17299060 
                 rs2342551 
                 T 
                 0.713 
                 10635 
                 7.54E−04 
                 1.16 
                 0.743 
                 1700 
                 1.23E−03 
                 1.14 
                 0.74 
                 2034 
               
               
                 C02 
                 128492107 
                 rs2244871 
                 C 
                 0.41 
                 10632 
                 7.62E−04 
                 1.14 
                 0.442 
                 1700 
                 7.38E−04 
                 1.13 
                 0.44 
                 2034 
               
               
                 C16 
                 75061517 
                 rs1862737 
                 C 
                 0.481 
                 10635 
                 7.67E−04 
                 1.14 
                 0.514 
                 1700 
                 1.75E−03 
                 1.12 
                 0.51 
                 2034 
               
               
                 C04 
                 129868334 
                 rs7690289 
                 T 
                 0.63 
                 10596 
                 7.70E−04 
                 1.15 
                 0.661 
                 1697 
                 7.24E−04 
                 1.14 
                 0.659 
                 2031 
               
               
                 C04 
                 129868334 
                 rs7690289 
                 T 
                 0.63 
                 10596 
                 7.70E−04 
                 1.15 
                 0.661 
                 1697 
                 7.24E−04 
                 1.14 
                 0.659 
                 2031 
               
               
                 C18 
                 73086657 
                 rs2156643 
                 G 
                 0.41 
                 10631 
                 7.70E−04 
                 1.14 
                 0.443 
                 1700 
                 1.49E−03 
                 1.12 
                 0.439 
                 2034 
               
               
                 C11 
                 7440298 
                 rs11041390 
                 A 
                 0.729 
                 10635 
                 7.70E−04 
                 1.16 
                 0.758 
                 1700 
                 8.75E−03 
                 1.12 
                 0.75 
                 2034 
               
               
                 C15 
                 34765482 
                 rs7183966 
                 G 
                 0.125 
                 10632 
                 7.75E−04 
                 1.21 
                 0.148 
                 1698 
                 3.73E−03 
                 1.17 
                 0.143 
                 2032 
               
               
                 C09 
                 28114180 
                 rs1452336 
                 A 
                 0.495 
                 10608 
                 7.76E−04 
                 1.14 
                 0.529 
                 1695 
                 1.89E−04 
                 1.15 
                 0.53 
                 2029 
               
               
                 C05 
                 102480237 
                 rs34374 
                 A 
                 0.671 
                 10635 
                 7.80E−04 
                 1.15 
                 0.702 
                 1699 
                 5.86E−03 
                 1.11 
                 0.695 
                 2033 
               
               
                 C05 
                 82104191 
                 rs6452479 
                 C 
                 0.934 
                 10595 
                 7.88E−04 
                 1.33 
                 0.95 
                 1695 
                 6.46E−04 
                 1.31 
                 0.949 
                 2028 
               
               
                 C18 
                 73085584 
                 rs2850889 
                 C 
                 0.41 
                 10634 
                 7.91E−04 
                 1.14 
                 0.443 
                 1700 
                 1.53E−03 
                 1.12 
                 0.439 
                 2034 
               
               
                 C11 
                 20014579 
                 rs920675 
                 A 
                 0.358 
                 10635 
                 7.95E−04 
                 1.15 
                 0.39 
                 1700 
                 5.37E−04 
                 1.14 
                 0.389 
                 2034 
               
               
                 C03 
                 39292564 
                 rs2853705 
                 T 
                 0.209 
                 10634 
                 7.97E−04 
                 1.17 
                 0.236 
                 1700 
                 2.79E−03 
                 1.14 
                 0.231 
                 2034 
               
               
                 C18 
                 73086818 
                 rs2850892 
                 C 
                 0.41 
                 10631 
                 7.98E−04 
                 1.14 
                 0.443 
                 1700 
                 1.55E−03 
                 1.12 
                 0.439 
                 2034 
               
               
                 C04 
                 178149338 
                 rs309770 
                 G 
                 0.889 
                 10635 
                 8.01E−04 
                 1.25 
                 0.909 
                 1700 
                 5.03E−04 
                 1.24 
                 0.908 
                 2034 
               
               
                 C11 
                 7444767 
                 rs7113222 
                 G 
                 0.739 
                 10632 
                 8.03E−04 
                 1.17 
                 0.768 
                 1700 
                 1.29E−02 
                 1.11 
                 0.759 
                 2034 
               
               
                 C03 
                 6735499 
                 rs7638636 
                 A 
                 0.494 
                 10231 
                 8.03E−04 
                 1.14 
                 0.528 
                 1648 
                 5.59E−04 
                 1.14 
                 0.526 
                 1972 
               
               
                 C02 
                 42489923 
                 rs10202624 
                 A 
                 0.094 
                 10634 
                 8.15E−04 
                 1.24 
                 0.114 
                 1700 
                 1.79E−04 
                 1.25 
                 0.114 
                 2034 
               
               
                 C06 
                 20707867 
                 rs2294809 
                 G 
                 0.799 
                 10626 
                 8.19E−04 
                 1.19 
                 0.825 
                 1699 
                 3.18E−03 
                 1.15 
                 0.82 
                 2033 
               
               
                 C02 
                 118487620 
                 rs2245113 
                 A 
                 0.174 
                 10632 
                 8.20E−04 
                 1.18 
                 0.199 
                 1700 
                 1.79E−02 
                 1.12 
                 0.191 
                 2034 
               
               
                 C19 
                 17024661 
                 rs2305758 
                 G 
                 0.684 
                 10633 
                 8.21E−04 
                 1.16 
                 0.714 
                 1700 
                 4.38E−04 
                 1.15 
                 0.714 
                 2034 
               
               
                 C19 
                 17024661 
                 rs2305758 
                 G 
                 0.684 
                 10633 
                 8.21E−04 
                 1.16 
                 0.714 
                 1700 
                 4.38E−04 
                 1.15 
                 0.714 
                 2034 
               
               
                 C01 
                 63908878 
                 rs1747924 
                 T 
                 0.808 
                 10622 
                 8.23E−04 
                 1.19 
                 0.834 
                 1700 
                 9.80E−03 
                 1.13 
                 0.827 
                 2034 
               
               
                 C22 
                 34883676 
                 rs5995259 
                 A 
                 0.337 
                 10635 
                 8.26E−04 
                 1.15 
                 0.369 
                 1700 
                 2.83E−03 
                 1.12 
                 0.363 
                 2034 
               
               
                 C02 
                 45292999 
                 rs908571 
                 C 
                 0.291 
                 10635 
                 8.27E−04 
                 1.15 
                 0.321 
                 1699 
                 1.62E−03 
                 1.13 
                 0.318 
                 2033 
               
               
                 C20 
                 33195666 
                 rs734484 
                 C 
                 0.709 
                 10635 
                 8.29E−04 
                 1.16 
                 0.738 
                 1699 
                 2.20E−03 
                 1.13 
                 0.734 
                 2033 
               
               
                 C16 
                 2009168 
                 rs8057913 
                 C 
                 0.264 
                 10634 
                 8.39E−04 
                 1.16 
                 0.293 
                 1700 
                 1.13E−03 
                 1.14 
                 0.29 
                 2034 
               
               
                 C03 
                 99699602 
                 rs3796139 
                 G 
                 0.145 
                 10476 
                 8.40E−04 
                 1.2 
                 0.169 
                 1685 
                 4.25E−03 
                 1.16 
                 0.164 
                 2011 
               
               
                 C02 
                 135194839 
                 rs1257208 
                 A 
                 0.138 
                 10633 
                 8.41E−04 
                 1.2 
                 0.161 
                 1700 
                 1.98E−03 
                 1.17 
                 0.158 
                 2034 
               
               
                 C20 
                 5928108 
                 rs236110 
                 G 
                 0.87 
                 10635 
                 8.43E−04 
                 1.23 
                 0.892 
                 1698 
                 9.17E−04 
                 1.21 
                 0.89 
                 2031 
               
               
                 C05 
                 3644654 
                 rs710998 
                 T 
                 0.899 
                 10630 
                 8.55E−04 
                 1.26 
                 0.918 
                 1699 
                 1.20E−03 
                 1.23 
                 0.917 
                 2033 
               
               
                 C02 
                 49398605 
                 rs6743414 
                 G 
                 0.847 
                 10634 
                 8.62E−04 
                 1.21 
                 0.87 
                 1700 
                 1.51E−04 
                 1.22 
                 0.871 
                 2034 
               
               
                 C13 
                 38516680 
                 rs9315759 
                 C 
                 0.13 
                 10635 
                 8.63E−04 
                 1.21 
                 0.152 
                 1700 
                 3.14E−03 
                 1.17 
                 0.148 
                 2034 
               
               
                 C01 
                 184657396 
                 rs4651384 
                 G 
                 0.687 
                 10634 
                 8.72E−04 
                 1.15 
                 0.717 
                 1700 
                 4.41E−03 
                 1.12 
                 0.711 
                 2034 
               
               
                 C19 
                 17031885 
                 rs12459084 
                 T 
                 0.351 
                 10633 
                 8.76E−04 
                 1.15 
                 0.382 
                 1700 
                 3.24E−03 
                 1.12 
                 0.376 
                 2034 
               
               
                 C17 
                 48847103 
                 rs4794128 
                 A 
                 0.272 
                 10634 
                 8.77E−04 
                 1.16 
                 0.302 
                 1700 
                 1.05E−03 
                 1.14 
                 0.299 
                 2034 
               
               
                 C08 
                 32544721 
                 rs12547858 
                 T 
                 0.195 
                 10624 
                 8.80E−04 
                 1.17 
                 0.221 
                 1700 
                 7.59E−04 
                 1.16 
                 0.22 
                 2034 
               
               
                 C09 
                 16318137 
                 rs4961695 
                 C 
                 0.803 
                 10614 
                 8.81E−04 
                 1.19 
                 0.829 
                 1697 
                 1.23E−03 
                 1.17 
                 0.826 
                 2029 
               
               
                 C02 
                 170296713 
                 rs2268365 
                 G 
                 0.125 
                 10635 
                 8.83E−04 
                 1.21 
                 0.147 
                 1698 
                 2.14E−03 
                 1.18 
                 0.144 
                 2032 
               
               
                 C02 
                 170296713 
                 rs2268365 
                 G 
                 0.125 
                 10635 
                 8.83E−04 
                 1.21 
                 0.147 
                 1698 
                 2.14E−03 
                 1.18 
                 0.144 
                 2032 
               
               
                 C07 
                 17752626 
                 rs4470902 
                 C 
                 0.417 
                 10634 
                 8.84E−04 
                 1.14 
                 0.45 
                 1700 
                 8.58E−04 
                 1.13 
                 0.447 
                 2034 
               
               
                 C14 
                 57303694 
                 rs17095237 
                 G 
                 0.16 
                 10634 
                 8.85E−04 
                 1.19 
                 0.185 
                 1700 
                 6.54E−03 
                 1.14 
                 0.179 
                 2034 
               
               
                 C05 
                 38969280 
                 rs357291 
                 C 
                 0.395 
                 10579 
                 8.89E−04 
                 1.14 
                 0.428 
                 1688 
                 6.20E−03 
                 1.11 
                 0.42 
                 2020 
               
               
                 C06 
                 30109076 
                 rs166327 
                 A 
                 0.601 
                 10634 
                 8.91E−04 
                 1.14 
                 0.633 
                 1700 
                 4.98E−03 
                 1.11 
                 0.626 
                 2034 
               
               
                 C03 
                 125374402 
                 rs6438839 
                 A 
                 0.077 
                 10632 
                 8.92E−04 
                 1.26 
                 0.095 
                 1700 
                 4.40E−04 
                 1.25 
                 0.095 
                 2034 
               
               
                 C05 
                 153231957 
                 rs1870739 
                 C 
                 0.855 
                 10629 
                 8.92E−04 
                 1.21 
                 0.877 
                 1697 
                 6.74E−03 
                 1.16 
                 0.872 
                 2031 
               
               
                 C01 
                 40507124 
                 rs661221 
                 G 
                 0.803 
                 10614 
                 8.92E−04 
                 1.19 
                 0.828 
                 1697 
                 8.83E−03 
                 1.13 
                 0.821 
                 2030 
               
               
                 C05 
                 50944695 
                 rs4865673 
                 G 
                 0.643 
                 10635 
                 8.94E−04 
                 1.15 
                 0.674 
                 1700 
                 1.99E−03 
                 1.13 
                 0.67 
                 2034 
               
               
                 C03 
                 186444329 
                 rs6803944 
                 C 
                 0.841 
                 10635 
                 8.95E−04 
                 1.21 
                 0.865 
                 1700 
                 7.54E−04 
                 1.19 
                 0.863 
                 2034 
               
               
                 C05 
                 102439618 
                 rs26434 
                 T 
                 0.704 
                 10617 
                 8.95E−04 
                 1.16 
                 0.734 
                 1697 
                 5.12E−03 
                 1.12 
                 0.727 
                 2031 
               
               
                 C10 
                 29327574 
                 rs788053 
                 T 
                 0.747 
                 10635 
                 9.01E−04 
                 1.17 
                 0.775 
                 1700 
                 1.80E−03 
                 1.14 
                 0.771 
                 2034 
               
               
                 C12 
                 101671864 
                 rs12311520 
                 C 
                 0.867 
                 10624 
                 9.12E−04 
                 1.22 
                 0.889 
                 1700 
                 5.86E−03 
                 1.17 
                 0.884 
                 2033 
               
               
                 C01 
                 29565842 
                 rs1932397 
                 G 
                 0.821 
                 10635 
                 9.14E−04 
                 1.19 
                 0.845 
                 1700 
                 2.07E−03 
                 1.16 
                 0.842 
                 2034 
               
               
                 C04 
                 10653042 
                 rs959233 
                 G 
                 0.445 
                 10622 
                 9.20E−04 
                 1.14 
                 0.477 
                 1700 
                 1.23E−03 
                 1.13 
                 0.474 
                 2033 
               
               
                 C08 
                 144018676 
                 rs5297 
                 C 
                 0.09 
                 10632 
                 9.22E−04 
                 1.24 
                 0.109 
                 1700 
                 4.01E−03 
                 1.19 
                 0.105 
                 2034 
               
               
                 C08 
                 143110958 
                 rs747551 
                 T 
                 0.436 
                 10633 
                 9.27E−04 
                 1.14 
                 0.469 
                 1700 
                 1.39E−03 
                 1.12 
                 0.465 
                 2034 
               
               
                 C18 
                 55790697 
                 rs8082768 
                 T 
                 0.18 
                 10621 
                 9.28E−04 
                 1.18 
                 0.206 
                 1700 
                 1.97E−04 
                 1.19 
                 0.207 
                 2034 
               
               
                 C12 
                 111537264 
                 rs1015249 
                 C 
                 0.689 
                 10635 
                 9.36E−04 
                 1.15 
                 0.719 
                 1700 
                 1.59E−03 
                 1.13 
                 0.715 
                 2034 
               
               
                 C08 
                 59026980 
                 rs7010934 
                 C 
                 0.842 
                 10632 
                 9.45E−04 
                 1.2 
                 0.865 
                 1700 
                 2.40E−03 
                 1.17 
                 0.862 
                 2034 
               
               
                 C01 
                 78361370 
                 rs1412414 
                 G 
                 0.621 
                 10634 
                 9.53E−04 
                 1.15 
                 0.652 
                 1699 
                 5.85E−03 
                 1.11 
                 0.645 
                 2033 
               
               
                 C06 
                 165543591 
                 rs1744503 
                 T 
                 0.478 
                 10631 
                 9.57E−04 
                 1.14 
                 0.511 
                 1700 
                 2.74E−04 
                 1.14 
                 0.512 
                 2033 
               
               
                 C01 
                 76521831 
                 rs10518531 
                 C 
                 0.842 
                 10561 
                 9.57E−04 
                 1.21 
                 0.865 
                 1668 
                 3.57E−04 
                 1.21 
                 0.865 
                 1998 
               
               
                 C12 
                 119365986 
                 rs719450 
                 C 
                 0.918 
                 10635 
                 9.57E−04 
                 1.29 
                 0.935 
                 1700 
                 2.69E−04 
                 1.3 
                 0.935 
                 2034 
               
               
                 C12 
                 119365986 
                 rs719450 
                 C 
                 0.918 
                 10635 
                 9.57E−04 
                 1.29 
                 0.935 
                 1700 
                 2.69E−04 
                 1.3 
                 0.935 
                 2034 
               
               
                 C03 
                 175246538 
                 rs1421420 
                 A 
                 0.725 
                 10633 
                 9.62E−04 
                 1.16 
                 0.754 
                 1700 
                 2.21E−02 
                 1.1 
                 0.743 
                 2034 
               
               
                 C06 
                 29542163 
                 rs2107191 
                 G 
                 0.439 
                 10634 
                 9.63E−04 
                 1.14 
                 0.471 
                 1700 
                 4.51E−03 
                 1.11 
                 0.465 
                 2034 
               
               
                 C06 
                 29542163 
                 rs2107191 
                 G 
                 0.439 
                 10634 
                 9.63E−04 
                 1.14 
                 0.471 
                 1700 
                 4.51E−03 
                 1.11 
                 0.465 
                 2034 
               
               
                 C05 
                 76806011 
                 rs3816609 
                 A 
                 0.356 
                 10632 
                 9.64E−04 
                 1.14 
                 0.387 
                 1700 
                 2.31E−03 
                 1.12 
                 0.382 
                 2034 
               
               
                 C18 
                 56570151 
                 rs2332026 
                 A 
                 0.499 
                 10634 
                 9.72E−04 
                 1.14 
                 0.532 
                 1700 
                 1.79E−03 
                 1.12 
                 0.528 
                 2034 
               
               
                 C17 
                 68940662 
                 rs312750 
                 C 
                 0.547 
                 10633 
                 9.72E−04 
                 1.14 
                 0.579 
                 1700 
                 7.18E−03 
                 1.1 
                 0.572 
                 2034 
               
               
                 C03 
                 72792674 
                 rs2208 
                 A 
                 0.265 
                 10634 
                 9.76E−04 
                 1.16 
                 0.294 
                 1700 
                 4.77E−03 
                 1.12 
                 0.288 
                 2034 
               
               
                 C03 
                 72733647 
                 rs7632726 
                 T 
                 0.307 
                 10635 
                 9.77E−04 
                 1.15 
                 0.337 
                 1700 
                 3.48E−03 
                 1.12 
                 0.332 
                 2034 
               
               
                 C03 
                 145911459 
                 rs4401402 
                 T 
                 0.583 
                 10633 
                 9.79E−04 
                 1.14 
                 0.615 
                 1700 
                 1.80E−03 
                 1.12 
                 0.611 
                 2034 
               
               
                 C04 
                 30752184 
                 rs4132132 
                 G 
                 0.439 
                 10618 
                 9.80E−04 
                 1.14 
                 0.471 
                 1696 
                 7.47E−04 
                 1.13 
                 0.47 
                 2030 
               
               
                 C01 
                 88967295 
                 rs10801705 
                 A 
                 0.456 
                 10635 
                 9.80E−04 
                 1.14 
                 0.489 
                 1699 
                 8.76E−04 
                 1.13 
                 0.487 
                 2033 
               
               
                 C10 
                 23151213 
                 rs2935689 
                 C 
                 0.837 
                 10635 
                 9.81E−04 
                 1.2 
                 0.86 
                 1700 
                 6.25E−03 
                 1.15 
                 0.855 
                 2034 
               
               
                 C18 
                 39875310 
                 rs1015735 
                 C 
                 0.262 
                 10605 
                 9.82E−04 
                 1.16 
                 0.291 
                 1695 
                 2.57E−03 
                 1.13 
                 0.286 
                 2029 
               
               
                 C04 
                 82259686 
                 rs10026644 
                 G 
                 0.926 
                 10619 
                 9.83E−04 
                 1.3 
                 0.942 
                 1697 
                 4.26E−03 
                 1.23 
                 0.939 
                 2028 
               
               
                 C20 
                 4111436 
                 rs1741285 
                 G 
                 0.56 
                 10634 
                 9.88E−04 
                 1.14 
                 0.592 
                 1698 
                 1.72E−03 
                 1.12 
                 0.588 
                 2032 
               
               
                 C20 
                 4111436 
                 rs1741285 
                 G 
                 0.56 
                 10634 
                 9.88E−04 
                 1.14 
                 0.592 
                 1698 
                 1.72E−03 
                 1.12 
                 0.588 
                 2032 
               
               
                 C14 
                 47963078 
                 rs8007161 
                 T 
                 0.884 
                 10602 
                 9.90E−04 
                 1.24 
                 0.904 
                 1698 
                 1.63E−03 
                 1.21 
                 0.901 
                 2030 
               
               
                 C14 
                 57288897 
                 rs392030 
                 G 
                 0.635 
                 10635 
                 9.98E−04 
                 1.15 
                 0.666 
                 1700 
                 2.27E−03 
                 1.12 
                 0.661 
                 2034 
               
               
                 C01 
                 19432522 
                 rs7523192 
                 T 
                 0.809 
                 10634 
                 1.01E−03 
                 1.19 
                 0.834 
                 1700 
                 2.17E−02 
                 1.12 
                 0.826 
                 2034 
               
               
                 C08 
                 144284828 
                 rs4977114 
                 C 
                 0.026 
                 10635 
                 1.01E−03 
                 1.44 
                 0.037 
                 1700 
                 7.98E−04 
                 1.42 
                 0.036 
                 2034 
               
               
                 CX 
                 4923358 
                 rs1919026 
                 C 
                 0.189 
                 8271 
                 1.02E−03 
                 1.22 
                 0.221 
                 1103 
                 4.66E−03 
                 1.17 
                 0.214 
                 1316 
               
               
                 C01 
                 18207864 
                 rs2946534 
                 T 
                 0.572 
                 10631 
                 1.03E−03 
                 1.14 
                 0.604 
                 1700 
                 7.54E−04 
                 1.13 
                 0.602 
                 2034 
               
               
                 C09 
                 28116482 
                 rs1452337 
                 G 
                 0.798 
                 10568 
                 1.03E−03 
                 1.18 
                 0.824 
                 1687 
                 1.01E−03 
                 1.17 
                 0.822 
                 2021 
               
               
                 C19 
                 17039119 
                 rs7254154 
                 C 
                 0.351 
                 10617 
                 1.03E−03 
                 1.14 
                 0.383 
                 1695 
                 3.90E−03 
                 1.12 
                 0.377 
                 2029 
               
               
                 C19 
                 17039119 
                 rs7254154 
                 C 
                 0.351 
                 10617 
                 1.03E−03 
                 1.14 
                 0.383 
                 1695 
                 3.90E−03 
                 1.12 
                 0.377 
                 2029 
               
               
                 C08 
                 73727022 
                 rs1837544 
                 G 
                 0.24 
                 10634 
                 1.03E−03 
                 1.16 
                 0.268 
                 1700 
                 2.02E−03 
                 1.14 
                 0.264 
                 2034 
               
               
                 C02 
                 183500703 
                 rs1946815 
                 G 
                 0.216 
                 10634 
                 1.03E−03 
                 1.17 
                 0.243 
                 1700 
                 2.25E−03 
                 1.14 
                 0.239 
                 2034 
               
               
                 C07 
                 102702234 
                 rs17152161 
                 C 
                 0.159 
                 10633 
                 1.03E−03 
                 1.19 
                 0.183 
                 1700 
                 5.79E−03 
                 1.14 
                 0.177 
                 2034 
               
               
                 C02 
                 216388367 
                 rs13417729 
                 C 
                 0.713 
                 10635 
                 1.04E−03 
                 1.16 
                 0.742 
                 1700 
                 1.20E−03 
                 1.14 
                 0.74 
                 2034 
               
               
                 C20 
                 13933789 
                 rs6079235 
                 C 
                 0.735 
                 10635 
                 1.04E−03 
                 1.16 
                 0.763 
                 1700 
                 1.05E−02 
                 1.11 
                 0.755 
                 2034 
               
               
                 C04 
                 8425936 
                 rs3756193 
                 G 
                 0.46 
                 10623 
                 1.05E−03 
                 1.14 
                 0.492 
                 1699 
                 2.26E−03 
                 1.12 
                 0.488 
                 2033 
               
               
                 C05 
                 76635083 
                 rs4704400 
                 T 
                 0.496 
                 10628 
                 1.06E−03 
                 1.14 
                 0.528 
                 1699 
                 3.23E−03 
                 1.11 
                 0.523 
                 2033 
               
               
                 C17 
                 17897321 
                 rs11649804 
                 A 
                 0.292 
                 10506 
                 1.06E−03 
                 1.15 
                 0.322 
                 1650 
                 7.96E−03 
                 1.11 
                 0.315 
                 1979 
               
               
                 C17 
                 17897321 
                 rs11649804 
                 A 
                 0.292 
                 10506 
                 1.06E−03 
                 1.15 
                 0.322 
                 1650 
                 7.96E−03 
                 1.11 
                 0.315 
                 1979 
               
               
                 C14 
                 64588026 
                 rs17754686 
                 A 
                 0.306 
                 10606 
                 1.06E−03 
                 1.15 
                 0.336 
                 1698 
                 1.49E−03 
                 1.13 
                 0.333 
                 2032 
               
               
                 C16 
                 2013121 
                 rs8045288 
                 T 
                 0.266 
                 10618 
                 1.06E−03 
                 1.15 
                 0.295 
                 1700 
                 1.23E−03 
                 1.14 
                 0.293 
                 2034 
               
               
                 C04 
                 139047812 
                 rs10028163 
                 G 
                 0.202 
                 10634 
                 1.06E−03 
                 1.17 
                 0.229 
                 1700 
                 4.06E−04 
                 1.17 
                 0.229 
                 2034 
               
               
                 C14 
                 98131730 
                 rs7158073 
                 T 
                 0.429 
                 10592 
                 1.06E−03 
                 1.14 
                 0.461 
                 1696 
                 2.61E−03 
                 1.12 
                 0.457 
                 2029 
               
               
                 C07 
                 42943442 
                 rs3757564 
                 C 
                 0.069 
                 10624 
                 1.07E−03 
                 1.27 
                 0.085 
                 1696 
                 1.02E−03 
                 1.25 
                 0.084 
                 2029 
               
               
                 C11 
                 110045689 
                 rs11604632 
                 A 
                 0.173 
                 10632 
                 1.07E−03 
                 1.18 
                 0.198 
                 1700 
                 4.90E−04 
                 1.18 
                 0.197 
                 2032 
               
               
                 C17 
                 17862368 
                 rs4925109 
                 A 
                 0.317 
                 10634 
                 1.07E−03 
                 1.15 
                 0.348 
                 1700 
                 3.75E−03 
                 1.12 
                 0.342 
                 2034 
               
               
                 C17 
                 17862368 
                 rs4925109 
                 A 
                 0.317 
                 10634 
                 1.07E−03 
                 1.15 
                 0.348 
                 1700 
                 3.75E−03 
                 1.12 
                 0.342 
                 2034 
               
               
                 C12 
                 96888528 
                 rs7135604 
                 A 
                 0.652 
                 10635 
                 1.07E−03 
                 1.15 
                 0.682 
                 1699 
                 2.11E−02 
                 1.09 
                 0.672 
                 2033 
               
               
                 C11 
                 97095503 
                 rs1039953 
                 C 
                 0.68 
                 10635 
                 1.08E−03 
                 1.15 
                 0.71 
                 1700 
                 1.67E−03 
                 1.13 
                 0.706 
                 2034 
               
               
                 C04 
                 163985671 
                 rs9991428 
                 G 
                 0.96 
                 10613 
                 1.08E−03 
                 1.44 
                 0.972 
                 1699 
                 3.03E−03 
                 1.35 
                 0.97 
                 2033 
               
               
                 C01 
                 148995481 
                 rs9826 
                 G 
                 0.326 
                 10553 
                 1.09E−03 
                 1.15 
                 0.357 
                 1687 
                 5.76E−03 
                 1.11 
                 0.35 
                 2016 
               
               
                 C15 
                 90440532 
                 rs6496899 
                 C 
                 0.763 
                 10468 
                 1.09E−03 
                 1.17 
                 0.79 
                 1684 
                 1.08E−03 
                 1.16 
                 0.788 
                 2015 
               
               
                 C17 
                 70257535 
                 rs9911654 
                 T 
                 0.894 
                 10635 
                 1.09E−03 
                 1.25 
                 0.913 
                 1700 
                 2.81E−02 
                 1.14 
                 0.906 
                 2034 
               
               
                 C06 
                 104259812 
                 rs9373729 
                 G 
                 0.355 
                 10623 
                 1.09E−03 
                 1.14 
                 0.386 
                 1698 
                 2.92E−03 
                 1.12 
                 0.381 
                 2032 
               
               
                 C05 
                 102509625 
                 rs34813 
                 G 
                 0.709 
                 10635 
                 1.11E−03 
                 1.16 
                 0.738 
                 1700 
                 8.32E−03 
                 1.11 
                 0.731 
                 2034 
               
               
                 C11 
                 134184293 
                 rs1289450 
                 A 
                 0.196 
                 10629 
                 1.11E−03 
                 1.17 
                 0.222 
                 1699 
                 5.54E−04 
                 1.17 
                 0.221 
                 2033 
               
               
                 C12 
                 69318052 
                 rs2584019 
                 T 
                 0.89 
                 10635 
                 1.11E−03 
                 1.24 
                 0.909 
                 1700 
                 2.22E−04 
                 1.26 
                 0.91 
                 2034 
               
               
                 C12 
                 69318052 
                 rs2584019 
                 T 
                 0.89 
                 10635 
                 1.11E−03 
                 1.24 
                 0.909 
                 1700 
                 2.22E−04 
                 1.26 
                 0.91 
                 2034 
               
               
                 C08 
                 79248604 
                 rs2369121 
                 T 
                 0.72 
                 10633 
                 1.11E−03 
                 1.16 
                 0.749 
                 1700 
                 8.70E−04 
                 1.15 
                 0.747 
                 2034 
               
               
                 C07 
                 23296885 
                 rs1542608 
                 G 
                 0.192 
                 10634 
                 1.11E−03 
                 1.17 
                 0.218 
                 1700 
                 1.53E−03 
                 1.15 
                 0.215 
                 2034 
               
               
                 C10 
                 15456765 
                 rs1925819 
                 T 
                 0.558 
                 10635 
                 1.11E−03 
                 1.14 
                 0.59 
                 1700 
                 1.40E−02 
                 1.09 
                 0.58 
                 2034 
               
               
                 C18 
                 3294629 
                 rs1791098 
                 C 
                 0.761 
                 10634 
                 1.11E−03 
                 1.17 
                 0.788 
                 1700 
                 1.78E−03 
                 1.15 
                 0.785 
                 2034 
               
               
                 C07 
                 150001841 
                 rs11762978 
                 A 
                 0.654 
                 10634 
                 1.11E−03 
                 1.15 
                 0.684 
                 1700 
                 8.03E−03 
                 1.11 
                 0.677 
                 2034 
               
               
                 C02 
                 209032070 
                 rs6435401 
                 A 
                 0.334 
                 10625 
                 1.13E−03 
                 1.14 
                 0.365 
                 1699 
                 3.65E−03 
                 1.12 
                 0.359 
                 2033 
               
               
                 C02 
                 85444821 
                 rs11675205 
                 A 
                 0.254 
                 10635 
                 1.13E−03 
                 1.16 
                 0.283 
                 1700 
                 1.59E−03 
                 1.14 
                 0.28 
                 2034 
               
               
                 C05 
                 158546004 
                 rs270654 
                 G 
                 0.133 
                 10635 
                 1.13E−03 
                 1.2 
                 0.156 
                 1700 
                 3.21E−03 
                 1.17 
                 0.152 
                 2034 
               
               
                 C05 
                 158546004 
                 rs270654 
                 G 
                 0.133 
                 10635 
                 1.13E−03 
                 1.2 
                 0.156 
                 1700 
                 3.21E−03 
                 1.17 
                 0.152 
                 2034 
               
               
                 CX 
                 40429441 
                 rs3013140 
                 G 
                 0.931 
                 8271 
                 1.14E−03 
                 1.4 
                 0.95 
                 1103 
                 8.63E−04 
                 1.38 
                 0.949 
                 1316 
               
               
                 C10 
                 78560604 
                 rs697171 
                 G 
                 0.91 
                 10620 
                 1.14E−03 
                 1.27 
                 0.928 
                 1697 
                 1.04E−02 
                 1.19 
                 0.923 
                 2030 
               
               
                 C04 
                 134880774 
                 rs4864193 
                 C 
                 0.959 
                 10626 
                 1.14E−03 
                 1.43 
                 0.971 
                 1700 
                 1.87E−04 
                 1.42 
                 0.971 
                 2034 
               
               
                 C12 
                 119366443 
                 rs3742049 
                 C 
                 0.918 
                 10622 
                 1.14E−03 
                 1.28 
                 0.935 
                 1699 
                 3.44E−04 
                 1.29 
                 0.936 
                 2033 
               
               
                 C22 
                 32544493 
                 rs2267296 
                 G 
                 0.444 
                 10634 
                 1.15E−03 
                 1.14 
                 0.476 
                 1700 
                 2.30E−03 
                 1.12 
                 0.472 
                 2034 
               
               
                 C12 
                 9208670 
                 rs3782677 
                 C 
                 0.548 
                 10635 
                 1.15E−03 
                 1.14 
                 0.579 
                 1700 
                 8.35E−03 
                 1.1 
                 0.572 
                 2034 
               
               
                 C18 
                 39882041 
                 rs4340393 
                 T 
                 0.261 
                 10635 
                 1.15E−03 
                 1.15 
                 0.289 
                 1700 
                 2.80E−03 
                 1.13 
                 0.285 
                 2034 
               
               
                 C06 
                 162239920 
                 rs875785 
                 C 
                 0.916 
                 10613 
                 1.15E−03 
                 1.28 
                 0.933 
                 1697 
                 3.18E−04 
                 1.29 
                 0.934 
                 2031 
               
               
                 C05 
                 102428250 
                 rs3776859 
                 T 
                 0.709 
                 10634 
                 1.15E−03 
                 1.15 
                 0.738 
                 1700 
                 8.34E−03 
                 1.11 
                 0.731 
                 2034 
               
               
                 C17 
                 72288299 
                 rs191227 
                 A 
                 0.572 
                 10632 
                 1.15E−03 
                 1.14 
                 0.604 
                 1700 
                 6.91E−04 
                 1.13 
                 0.603 
                 2033 
               
               
                 C07 
                 38886642 
                 rs11763728 
                 T 
                 0.332 
                 10635 
                 1.15E−03 
                 1.14 
                 0.363 
                 1700 
                 1.57E−03 
                 1.13 
                 0.36 
                 2034 
               
               
                 C05 
                 157527972 
                 rs716376 
                 G 
                 0.182 
                 10635 
                 1.16E−03 
                 1.17 
                 0.208 
                 1700 
                 4.51E−03 
                 1.14 
                 0.203 
                 2034 
               
               
                 C06 
                 156331097 
                 rs4512236 
                 T 
                 0.418 
                 10634 
                 1.17E−03 
                 1.14 
                 0.45 
                 1700 
                 9.53E−04 
                 1.13 
                 0.448 
                 2034 
               
               
                 C12 
                 111845540 
                 rs1293758 
                 A 
                 0.407 
                 10633 
                 1.17E−03 
                 1.14 
                 0.439 
                 1700 
                 6.83E−04 
                 1.13 
                 0.438 
                 2034 
               
               
                 C08 
                 32600898 
                 rs10503927 
                 T 
                 0.471 
                 10635 
                 1.17E−03 
                 1.14 
                 0.503 
                 1700 
                 2.49E−03 
                 1.12 
                 0.498 
                 2034 
               
               
                 C03 
                 175270719 
                 rs2111956 
                 G 
                 0.758 
                 10633 
                 1.17E−03 
                 1.17 
                 0.785 
                 1700 
                 3.73E−02 
                 1.09 
                 0.774 
                 2033 
               
               
                 C02 
                 229956337 
                 rs9288639 
                 C 
                 0.076 
                 10621 
                 1.18E−03 
                 1.26 
                 0.093 
                 1697 
                 1.45E−02 
                 1.18 
                 0.088 
                 2030 
               
               
                 C01 
                 148893831 
                 rs2495392 
                 G 
                 0.274 
                 10629 
                 1.18E−03 
                 1.15 
                 0.303 
                 1700 
                 7.91E−03 
                 1.11 
                 0.296 
                 2034 
               
               
                 C12 
                 9208040 
                 rs3213831 
                 T 
                 0.547 
                 10635 
                 1.18E−03 
                 1.14 
                 0.579 
                 1700 
                 8.97E−03 
                 1.1 
                 0.571 
                 2034 
               
               
                 C14 
                 63868848 
                 rs1953416 
                 T 
                 0.482 
                 10627 
                 1.18E−03 
                 1.14 
                 0.514 
                 1698 
                 4.79E−03 
                 1.11 
                 0.508 
                 2032 
               
               
                 C17 
                 37372424 
                 rs7210156 
                 G 
                 0.93 
                 10631 
                 1.18E−03 
                 1.31 
                 0.946 
                 1699 
                 3.16E−03 
                 1.25 
                 0.943 
                 2033 
               
               
                 C16 
                 63942198 
                 rs7192142 
                 T 
                 0.811 
                 10602 
                 1.18E−03 
                 1.18 
                 0.835 
                 1693 
                 2.07E−03 
                 1.16 
                 0.833 
                 2025 
               
               
                 C10 
                 15465576 
                 rs1013406 
                 C 
                 0.561 
                 10623 
                 1.18E−03 
                 1.14 
                 0.593 
                 1697 
                 1.35E−02 
                 1.1 
                 0.583 
                 2030 
               
               
                 C12 
                 65812323 
                 rs11835794 
                 T 
                 0.852 
                 10635 
                 1.18E−03 
                 1.21 
                 0.874 
                 1700 
                 1.80E−04 
                 1.22 
                 0.876 
                 2034 
               
               
                 C05 
                 57500192 
                 rs2112905 
                 A 
                 0.402 
                 10635 
                 1.19E−03 
                 1.14 
                 0.433 
                 1700 
                 4.16E−03 
                 1.11 
                 0.427 
                 2034 
               
               
                 C04 
                 33363983 
                 rs10517277 
                 C 
                 0.102 
                 10629 
                 1.19E−03 
                 1.22 
                 0.122 
                 1700 
                 3.92E−03 
                 1.18 
                 0.118 
                 2034 
               
               
                 C07 
                 37924826 
                 rs1357648 
                 T 
                 0.318 
                 10602 
                 1.20E−03 
                 1.14 
                 0.348 
                 1691 
                 2.54E−03 
                 1.12 
                 0.344 
                 2024 
               
               
                 C05 
                 158795428 
                 rs10045431 
                 A 
                 0.262 
                 10582 
                 1.20E−03 
                 1.15 
                 0.291 
                 1675 
                 6.80E−03 
                 1.12 
                 0.285 
                 2007 
               
               
                 C22 
                 32522356 
                 rs8135273 
                 C 
                 0.156 
                 10593 
                 1.20E−03 
                 1.19 
                 0.18 
                 1689 
                 9.52E−03 
                 1.14 
                 0.174 
                 2020 
               
               
                 C04 
                 162467610 
                 rs12503470 
                 T 
                 0.378 
                 10632 
                 1.20E−03 
                 1.14 
                 0.409 
                 1700 
                 4.24E−03 
                 1.11 
                 0.403 
                 2034 
               
               
                 C04 
                 162156054 
                 rs17359034 
                 T 
                 0.386 
                 10551 
                 1.20E−03 
                 1.14 
                 0.417 
                 1700 
                 1.11E−02 
                 1.1 
                 0.409 
                 2034 
               
               
                 C14 
                 51013885 
                 rs1458114 
                 T 
                 0.708 
                 10457 
                 1.21E−03 
                 1.16 
                 0.737 
                 1653 
                 4.43E−03 
                 1.12 
                 0.732 
                 1982 
               
               
                 C02 
                 127990589 
                 rs3943703 
                 C 
                 0.211 
                 10632 
                 1.21E−03 
                 1.16 
                 0.237 
                 1700 
                 5.13E−04 
                 1.16 
                 0.237 
                 2034 
               
               
                 C07 
                 85202542 
                 rs10276025 
                 T 
                 0.372 
                 10635 
                 1.22E−03 
                 1.14 
                 0.403 
                 1700 
                 1.23E−03 
                 1.13 
                 0.401 
                 2034 
               
               
                 C18 
                 58474237 
                 rs7241455 
                 T 
                 0.061 
                 10635 
                 1.22E−03 
                 1.28 
                 0.077 
                 1700 
                 3.10E−04 
                 1.29 
                 0.078 
                 2034 
               
               
                 C15 
                 90437337 
                 rs3743369 
                 T 
                 0.61 
                 10633 
                 1.22E−03 
                 1.14 
                 0.641 
                 1700 
                 8.00E−04 
                 1.13 
                 0.639 
                 2034 
               
               
                 C03 
                 72701976 
                 rs2046867 
                 T 
                 0.276 
                 10630 
                 1.23E−03 
                 1.15 
                 0.305 
                 1700 
                 7.59E−03 
                 1.11 
                 0.298 
                 2034 
               
               
                 C05 
                 52576529 
                 rs38055 
                 T 
                 0.383 
                 10632 
                 1.23E−03 
                 1.14 
                 0.414 
                 1700 
                 3.56E−05 
                 1.17 
                 0.42 
                 2034 
               
               
                 C08 
                 70844508 
                 rs7015359 
                 G 
                 0.186 
                 10635 
                 1.23E−03 
                 1.17 
                 0.211 
                 1700 
                 1.45E−03 
                 1.16 
                 0.209 
                 2034 
               
               
                 C17 
                 17015262 
                 rs4401079 
                 T 
                 0.21 
                 10418 
                 1.23E−03 
                 1.17 
                 0.236 
                 1666 
                 3.95E−04 
                 1.17 
                 0.237 
                 1992 
               
               
                 C10 
                 23293068 
                 rs10828393 
                 C 
                 0.891 
                 10615 
                 1.23E−03 
                 1.24 
                 0.91 
                 1698 
                 3.82E−03 
                 1.19 
                 0.907 
                 2032 
               
               
                 C14 
                 57437666 
                 rs11158238 
                 T 
                 0.141 
                 10634 
                 1.24E−03 
                 1.19 
                 0.163 
                 1700 
                 3.43E−03 
                 1.16 
                 0.16 
                 2034 
               
               
                 C08 
                 97736809 
                 rs1075479 
                 A 
                 0.79 
                 10601 
                 1.24E−03 
                 1.17 
                 0.815 
                 1696 
                 7.77E−03 
                 1.13 
                 0.81 
                 2029 
               
               
                 C07 
                 21550808 
                 rs4722054 
                 G 
                 0.087 
                 10596 
                 1.25E−03 
                 1.24 
                 0.105 
                 1682 
                 1.77E−03 
                 1.21 
                 0.103 
                 2014 
               
               
                 C22 
                 34890870 
                 rs763086 
                 A 
                 0.299 
                 10624 
                 1.26E−03 
                 1.15 
                 0.329 
                 1699 
                 2.88E−03 
                 1.12 
                 0.324 
                 2031 
               
               
                 C19 
                 4187996 
                 rs4740 
                 A 
                 0.269 
                 10634 
                 1.26E−03 
                 1.15 
                 0.298 
                 1700 
                 5.17E−03 
                 1.12 
                 0.292 
                 2034 
               
               
                 C12 
                 75974496 
                 rs7135414 
                 A 
                 0.914 
                 10635 
                 1.26E−03 
                 1.27 
                 0.931 
                 1700 
                 5.96E−03 
                 1.21 
                 0.928 
                 2034 
               
               
                 C12 
                 75974496 
                 rs7135414 
                 A 
                 0.914 
                 10635 
                 1.26E−03 
                 1.27 
                 0.931 
                 1700 
                 5.96E−03 
                 1.21 
                 0.928 
                 2034 
               
               
                 C05 
                 5893171 
                 rs864267 
                 A 
                 0.452 
                 10633 
                 1.26E−03 
                 1.14 
                 0.483 
                 1700 
                 1.57E−03 
                 1.12 
                 0.48 
                 2034 
               
               
                 C12 
                 121504211 
                 rs10847227 
                 T 
                 0.273 
                 10616 
                 1.26E−03 
                 1.15 
                 0.301 
                 1700 
                 1.46E−04 
                 1.16 
                 0.304 
                 2034 
               
               
                 C08 
                 97440350 
                 rs1992087 
                 G 
                 0.254 
                 10635 
                 1.27E−03 
                 1.15 
                 0.282 
                 1700 
                 2.92E−03 
                 1.13 
                 0.278 
                 2034 
               
               
                 C13 
                 53306486 
                 rs1993776 
                 C 
                 0.869 
                 10635 
                 1.28E−03 
                 1.22 
                 0.889 
                 1700 
                 2.60E−03 
                 1.18 
                 0.887 
                 2034 
               
               
                 C19 
                 17080105 
                 rs7246865 
                 A 
                 0.205 
                 10635 
                 1.28E−03 
                 1.17 
                 0.231 
                 1700 
                 3.11E−03 
                 1.14 
                 0.227 
                 2034 
               
               
                 C19 
                 17080105 
                 rs7246865 
                 A 
                 0.205 
                 10635 
                 1.28E−03 
                 1.17 
                 0.231 
                 1700 
                 3.11E−03 
                 1.14 
                 0.227 
                 2034 
               
               
                 C04 
                 178163770 
                 rs309800 
                 C 
                 0.798 
                 10632 
                 1.28E−03 
                 1.18 
                 0.823 
                 1699 
                 1.30E−04 
                 1.2 
                 0.826 
                 2033 
               
               
                 C05 
                 57486156 
                 rs2962014 
                 G 
                 0.501 
                 10528 
                 1.28E−03 
                 1.14 
                 0.533 
                 1682 
                 4.01E−03 
                 1.11 
                 0.528 
                 2015 
               
               
                 C19 
                 14236895 
                 rs7248277 
                 C 
                 0.563 
                 10624 
                 1.29E−03 
                 1.14 
                 0.594 
                 1699 
                 5.08E−04 
                 1.14 
                 0.594 
                 2033 
               
               
                 C01 
                 30315299 
                 rs407838 
                 C 
                 0.843 
                 10633 
                 1.29E−03 
                 1.2 
                 0.865 
                 1700 
                 7.85E−04 
                 1.19 
                 0.865 
                 2034 
               
               
                 C01 
                 184669059 
                 rs2250227 
                 C 
                 0.337 
                 10635 
                 1.29E−03 
                 1.14 
                 0.367 
                 1700 
                 3.60E−03 
                 1.12 
                 0.362 
                 2034 
               
               
                 C04 
                 17186841 
                 rs2697684 
                 G 
                 0.771 
                 10635 
                 1.29E−03 
                 1.17 
                 0.798 
                 1700 
                 1.46E−03 
                 1.15 
                 0.795 
                 2034 
               
               
                 C10 
                 85007873 
                 rs11199316 
                 C 
                 0.713 
                 10568 
                 1.29E−03 
                 1.15 
                 0.742 
                 1687 
                 1.02E−04 
                 1.17 
                 0.745 
                 2019 
               
               
                 CX 
                 84984650 
                 rs2213468 
                 G 
                 0.659 
                 8219 
                 1.30E−03 
                 1.18 
                 0.696 
                 1094 
                 2.51E−03 
                 1.16 
                 0.691 
                 1307 
               
               
                 CX 
                 66115625 
                 rs2031751 
                 C 
                 0.941 
                 8270 
                 1.30E−03 
                 1.44 
                 0.959 
                 1102 
                 8.21E−03 
                 1.31 
                 0.955 
                 1315 
               
               
                 C02 
                 212342079 
                 rs4442936 
                 G 
                 0.282 
                 10600 
                 1.32E−03 
                 1.15 
                 0.311 
                 1683 
                 9.92E−04 
                 1.14 
                 0.309 
                 2016 
               
               
                 C01 
                 162568432 
                 rs2651860 
                 T 
                 0.786 
                 10635 
                 1.32E−03 
                 1.17 
                 0.811 
                 1700 
                 4.88E−03 
                 1.14 
                 0.806 
                 2033 
               
               
                 C02 
                 135143228 
                 rs10496721 
                 T 
                 0.17 
                 10631 
                 1.32E−03 
                 1.18 
                 0.195 
                 1699 
                 6.12E−03 
                 1.14 
                 0.189 
                 2033 
               
               
                 C04 
                 129841129 
                 rs6534683 
                 T 
                 0.646 
                 10635 
                 1.32E−03 
                 1.14 
                 0.676 
                 1700 
                 8.61E−04 
                 1.14 
                 0.675 
                 2034 
               
               
                 C05 
                 108055795 
                 rs4957775 
                 G 
                 0.832 
                 10635 
                 1.33E−03 
                 1.19 
                 0.855 
                 1700 
                 1.22E−03 
                 1.18 
                 0.853 
                 2034 
               
               
                 C13 
                 21281716 
                 rs1887263 
                 A 
                 0.204 
                 10630 
                 1.33E−03 
                 1.16 
                 0.229 
                 1700 
                 1.56E−03 
                 1.15 
                 0.227 
                 2034 
               
               
                 C12 
                 120804218 
                 rs1169081 
                 C 
                 0.692 
                 10626 
                 1.33E−03 
                 1.15 
                 0.721 
                 1700 
                 2.42E−02 
                 1.09 
                 0.711 
                 2034 
               
               
                 C11 
                 68636018 
                 rs7111999 
                 G 
                 0.47 
                 10494 
                 1.33E−03 
                 1.14 
                 0.502 
                 1666 
                 1.94E−02 
                 1.09 
                 0.492 
                 1994 
               
               
                 C13 
                 36900184 
                 rs9566343 
                 T 
                 0.814 
                 10634 
                 1.34E−03 
                 1.18 
                 0.838 
                 1700 
                 9.66E−04 
                 1.17 
                 0.837 
                 2034 
               
               
                 C12 
                 22807863 
                 rs16925384 
                 A 
                 0.194 
                 10621 
                 1.34E−03 
                 1.17 
                 0.219 
                 1699 
                 1.79E−03 
                 1.15 
                 0.216 
                 2033 
               
               
                 C01 
                 149009396 
                 rs949969 
                 T 
                 0.195 
                 10635 
                 1.34E−03 
                 1.17 
                 0.221 
                 1700 
                 2.26E−03 
                 1.15 
                 0.218 
                 2034 
               
               
                 C14 
                 64466293 
                 rs894921 
                 G 
                 0.377 
                 10633 
                 1.35E−03 
                 1.14 
                 0.408 
                 1700 
                 1.12E−02 
                 1.1 
                 0.4 
                 2034 
               
               
                 C10 
                 15419285 
                 rs11596590 
                 T 
                 0.559 
                 10634 
                 1.35E−03 
                 1.14 
                 0.59 
                 1699 
                 1.36E−02 
                 1.1 
                 0.581 
                 2033 
               
               
                 C11 
                 90747051 
                 rs1436622 
                 A 
                 0.686 
                 10633 
                 1.35E−03 
                 1.15 
                 0.715 
                 1700 
                 5.93E−04 
                 1.15 
                 0.715 
                 2034 
               
               
                 C08 
                 129199390 
                 rs10505507 
                 A 
                 0.924 
                 10634 
                 1.36E−03 
                 1.29 
                 0.94 
                 1700 
                 5.90E−03 
                 1.22 
                 0.937 
                 2034 
               
               
                 C18 
                 45713028 
                 rs1790778 
                 G 
                 0.512 
                 10632 
                 1.36E−03 
                 1.13 
                 0.544 
                 1699 
                 1.91E−03 
                 1.12 
                 0.54 
                 2033 
               
               
                 C07 
                 85200311 
                 rs2373018 
                 G 
                 0.372 
                 10635 
                 1.36E−03 
                 1.14 
                 0.403 
                 1700 
                 1.35E−03 
                 1.13 
                 0.401 
                 2034 
               
               
                 C14 
                 57397846 
                 rs10483707 
                 A 
                 0.139 
                 10635 
                 1.36E−03 
                 1.19 
                 0.161 
                 1700 
                 5.05E−03 
                 1.15 
                 0.157 
                 2034 
               
               
                 C20 
                 5929566 
                 rs236113 
                 T 
                 0.883 
                 10635 
                 1.37E−03 
                 1.23 
                 0.902 
                 1700 
                 3.33E−03 
                 1.19 
                 0.899 
                 2034 
               
               
                 C07 
                 11501113 
                 rs1526543 
                 T 
                 0.829 
                 10634 
                 1.37E−03 
                 1.19 
                 0.852 
                 1700 
                 3.94E−03 
                 1.15 
                 0.849 
                 2034 
               
               
                 C05 
                 5904611 
                 rs2617549 
                 A 
                 0.453 
                 10629 
                 1.38E−03 
                 1.13 
                 0.485 
                 1700 
                 1.57E−03 
                 1.12 
                 0.482 
                 2034 
               
               
                 C02 
                 36022756 
                 rs6747236 
                 T 
                 0.716 
                 10628 
                 1.38E−03 
                 1.15 
                 0.744 
                 1700 
                 4.89E−04 
                 1.15 
                 0.744 
                 2034 
               
               
                 C10 
                 8304796 
                 rs7092384 
                 C 
                 0.86 
                 10629 
                 1.39E−03 
                 1.21 
                 0.881 
                 1700 
                 1.31E−03 
                 1.19 
                 0.88 
                 2034 
               
               
                 C02 
                 42505686 
                 rs6724757 
                 A 
                 0.09 
                 10631 
                 1.40E−03 
                 1.23 
                 0.109 
                 1699 
                 3.19E−04 
                 1.24 
                 0.109 
                 2033 
               
               
                 C05 
                 66155122 
                 rs2441109 
                 G 
                 0.162 
                 10633 
                 1.40E−03 
                 1.18 
                 0.186 
                 1700 
                 1.58E−02 
                 1.12 
                 0.179 
                 2034 
               
               
                 C10 
                 131748550 
                 rs1484652 
                 T 
                 0.905 
                 10635 
                 1.40E−03 
                 1.26 
                 0.923 
                 1700 
                 8.26E−03 
                 1.19 
                 0.919 
                 2034 
               
               
                 C16 
                 2010569 
                 rs2286472 
                 C 
                 0.269 
                 10627 
                 1.40E−03 
                 1.15 
                 0.297 
                 1690 
                 2.09E−03 
                 1.13 
                 0.294 
                 2024 
               
               
                 C05 
                 39122462 
                 rs6880882 
                 A 
                 0.352 
                 10599 
                 1.41E−03 
                 1.14 
                 0.382 
                 1697 
                 3.56E−03 
                 1.12 
                 0.377 
                 2028 
               
               
                 C16 
                 88204775 
                 rs4075964 
                 A 
                 0.284 
                 10632 
                 1.41E−03 
                 1.15 
                 0.312 
                 1699 
                 1.71E−03 
                 1.13 
                 0.31 
                 2033 
               
               
                 C09 
                 28113402 
                 rs1452335 
                 G 
                 0.715 
                 10614 
                 1.41E−03 
                 1.15 
                 0.744 
                 1694 
                 6.47E−04 
                 1.15 
                 0.743 
                 2027 
               
               
                 C14 
                 31305463 
                 rs1950216 
                 T 
                 0.798 
                 10634 
                 1.41E−03 
                 1.18 
                 0.823 
                 1700 
                 3.06E−03 
                 1.15 
                 0.82 
                 2034 
               
               
                 C13 
                 45766462 
                 rs9526329 
                 G 
                 0.921 
                 10632 
                 1.41E−03 
                 1.28 
                 0.938 
                 1700 
                 3.25E−03 
                 1.23 
                 0.935 
                 2034 
               
               
                 C11 
                 14150002 
                 rs10832223 
                 T 
                 0.837 
                 10626 
                 1.41E−03 
                 1.19 
                 0.86 
                 1700 
                 2.90E−03 
                 1.16 
                 0.857 
                 2034 
               
               
                 C02 
                 77672532 
                 rs2861078 
                 T 
                 0.57 
                 10635 
                 1.42E−03 
                 1.14 
                 0.601 
                 1700 
                 1.64E−03 
                 1.12 
                 0.599 
                 2034 
               
               
                 C01 
                 62762582 
                 rs11208061 
                 A 
                 0.345 
                 10547 
                 1.42E−03 
                 1.14 
                 0.375 
                 1697 
                 3.56E−03 
                 1.12 
                 0.37 
                 2029 
               
               
                 C20 
                 49529811 
                 rs4811008 
                 G 
                 0.461 
                 10463 
                 1.42E−03 
                 1.14 
                 0.493 
                 1668 
                 3.89E−03 
                 1.11 
                 0.488 
                 1996 
               
               
                 C14 
                 102711567 
                 rs8016595 
                 C 
                 0.754 
                 10630 
                 1.43E−03 
                 1.16 
                 0.781 
                 1700 
                 4.46E−03 
                 1.13 
                 0.776 
                 2034 
               
               
                 C01 
                 243972662 
                 rs12068067 
                 G 
                 0.776 
                 10589 
                 1.43E−03 
                 1.17 
                 0.801 
                 1695 
                 9.78E−04 
                 1.16 
                 0.8 
                 2029 
               
               
                 C10 
                 84836912 
                 rs10787854 
                 A 
                 0.83 
                 10634 
                 1.43E−03 
                 1.19 
                 0.853 
                 1700 
                 2.82E−04 
                 1.2 
                 0.854 
                 2034 
               
               
                 CX 
                 55725022 
                 rs5914778 
                 G 
                 0.802 
                 8269 
                 1.44E−03 
                 1.22 
                 0.832 
                 1103 
                 6.95E−04 
                 1.22 
                 0.831 
                 1316 
               
               
                 C05 
                 102584028 
                 rs183752 
                 T 
                 0.716 
                 10621 
                 1.44E−03 
                 1.15 
                 0.744 
                 1699 
                 1.26E−02 
                 1.11 
                 0.736 
                 2033 
               
               
                 C14 
                 31304803 
                 rs991387 
                 G 
                 0.799 
                 10634 
                 1.44E−03 
                 1.18 
                 0.823 
                 1700 
                 3.12E−03 
                 1.15 
                 0.82 
                 2034 
               
               
                 C11 
                 68632276 
                 rs1005858 
                 G 
                 0.47 
                 10634 
                 1.45E−03 
                 1.13 
                 0.502 
                 1700 
                 2.30E−02 
                 1.09 
                 0.491 
                 2034 
               
               
                 C03 
                 195828700 
                 rs4497978 
                 A 
                 0.667 
                 10576 
                 1.45E−03 
                 1.15 
                 0.696 
                 1682 
                 2.58E−03 
                 1.13 
                 0.693 
                 2012 
               
               
                 C05 
                 40656007 
                 rs13175020 
                 T 
                 0.816 
                 10632 
                 1.46E−03 
                 1.18 
                 0.84 
                 1699 
                 4.64E−04 
                 1.19 
                 0.841 
                 2033 
               
               
                 C01 
                 62822706 
                 rs6696619 
                 C 
                 0.662 
                 10624 
                 1.46E−03 
                 1.14 
                 0.692 
                 1700 
                 6.63E−04 
                 1.14 
                 0.691 
                 2034 
               
               
                 C13 
                 104637486 
                 rs354438 
                 T 
                 0.351 
                 10634 
                 1.46E−03 
                 1.14 
                 0.381 
                 1700 
                 5.60E−04 
                 1.14 
                 0.381 
                 2034 
               
               
                 C14 
                 64464393 
                 rs1147437 
                 G 
                 0.38 
                 10634 
                 1.46E−03 
                 1.14 
                 0.411 
                 1700 
                 8.57E−03 
                 1.1 
                 0.403 
                 2034 
               
               
                 C17 
                 295873 
                 rs4130140 
                 A 
                 0.175 
                 10635 
                 1.46E−03 
                 1.17 
                 0.199 
                 1700 
                 4.28E−03 
                 1.14 
                 0.195 
                 2034 
               
               
                 C07 
                 20937657 
                 rs2110007 
                 C 
                 0.943 
                 10606 
                 1.47E−03 
                 1.34 
                 0.956 
                 1699 
                 1.90E−03 
                 1.3 
                 0.955 
                 2030 
               
               
                 C21 
                 26986173 
                 rs2251540 
                 G 
                 0.642 
                 10633 
                 1.47E−03 
                 1.14 
                 0.672 
                 1700 
                 7.17E−04 
                 1.14 
                 0.671 
                 2034 
               
               
                 C10 
                 23311212 
                 rs993352 
                 G 
                 0.883 
                 10593 
                 1.47E−03 
                 1.23 
                 0.903 
                 1689 
                 4.02E−03 
                 1.19 
                 0.9 
                 2021 
               
               
                 C04 
                 139831081 
                 rs7669668 
                 T 
                 0.119 
                 10635 
                 1.48E−03 
                 1.2 
                 0.139 
                 1700 
                 1.69E−02 
                 1.14 
                 0.133 
                 2034 
               
               
                 C02 
                 172634850 
                 rs1399959 
                 G 
                 0.669 
                 10611 
                 1.48E−03 
                 1.14 
                 0.698 
                 1699 
                 1.32E−02 
                 1.1 
                 0.69 
                 2032 
               
               
                 C06 
                 127842427 
                 rs11154416 
                 G 
                 0.76 
                 10566 
                 1.49E−03 
                 1.16 
                 0.787 
                 1684 
                 5.06E−03 
                 1.13 
                 0.782 
                 2016 
               
               
                 C12 
                 22797592 
                 rs2171392 
                 A 
                 0.194 
                 10635 
                 1.49E−03 
                 1.17 
                 0.219 
                 1700 
                 2.03E−03 
                 1.15 
                 0.217 
                 2034 
               
               
                 C07 
                 17747986 
                 rs11766489 
                 T 
                 0.423 
                 10635 
                 1.49E−03 
                 1.13 
                 0.454 
                 1700 
                 1.74E−03 
                 1.12 
                 0.451 
                 2034 
               
               
                 C20 
                 4116799 
                 rs6084644 
                 G 
                 0.436 
                 10635 
                 1.49E−03 
                 1.13 
                 0.467 
                 1700 
                 2.33E−03 
                 1.12 
                 0.464 
                 2034 
               
               
                 C20 
                 4116799 
                 rs6084644 
                 G 
                 0.436 
                 10635 
                 1.49E−03 
                 1.13 
                 0.467 
                 1700 
                 2.33E−03 
                 1.12 
                 0.464 
                 2034 
               
               
                 C18 
                 70239058 
                 rs4892210 
                 A 
                 0.192 
                 10634 
                 1.49E−03 
                 1.17 
                 0.217 
                 1700 
                 8.76E−04 
                 1.16 
                 0.216 
                 2034 
               
               
                 C01 
                 153057498 
                 rs822519 
                 A 
                 0.932 
                 10635 
                 1.50E−03 
                 1.3 
                 0.947 
                 1700 
                 8.24E−04 
                 1.3 
                 0.946 
                 2034 
               
               
                 C10 
                 5181871 
                 rs4880711 
                 C 
                 0.35 
                 10503 
                 1.51E−03 
                 1.14 
                 0.38 
                 1693 
                 2.56E−02 
                 1.09 
                 0.37 
                 2017 
               
               
                 C14 
                 101394200 
                 rs10129841 
                 A 
                 0.577 
                 10634 
                 1.51E−03 
                 1.14 
                 0.608 
                 1700 
                 4.86E−03 
                 1.11 
                 0.603 
                 2034 
               
               
                 C07 
                 38982261 
                 rs4478468 
                 G 
                 0.31 
                 10635 
                 1.52E−03 
                 1.14 
                 0.339 
                 1700 
                 1.46E−03 
                 1.13 
                 0.337 
                 2034 
               
               
                 C08 
                 39425796 
                 rs7830101 
                 T 
                 0.274 
                 10556 
                 1.53E−03 
                 1.15 
                 0.302 
                 1686 
                 2.51E−03 
                 1.13 
                 0.299 
                 2019 
               
               
                 C16 
                 19860174 
                 rs1634675 
                 G 
                 0.787 
                 10633 
                 1.53E−03 
                 1.17 
                 0.812 
                 1700 
                 6.40E−03 
                 1.13 
                 0.807 
                 2034 
               
               
                 C08 
                 75342454 
                 rs6996971 
                 C 
                 0.476 
                 10603 
                 1.53E−03 
                 1.13 
                 0.507 
                 1698 
                 2.99E−04 
                 1.14 
                 0.509 
                 2032 
               
               
                 C05 
                 102596616 
                 rs26821 
                 A 
                 0.709 
                 10628 
                 1.53E−03 
                 1.15 
                 0.737 
                 1697 
                 1.27E−02 
                 1.11 
                 0.73 
                 2031 
               
               
                 C19 
                 330003 
                 rs10414677 
                 T 
                 0.276 
                 10341 
                 1.53E−03 
                 1.15 
                 0.305 
                 1639 
                 1.23E−02 
                 1.11 
                 0.297 
                 1956 
               
               
                 C14 
                 64458802 
                 rs1147443 
                 T 
                 0.254 
                 10635 
                 1.54E−03 
                 1.15 
                 0.281 
                 1700 
                 2.45E−03 
                 1.13 
                 0.278 
                 2034 
               
               
                 C11 
                 108465132 
                 rs1509729 
                 G 
                 0.688 
                 10634 
                 1.55E−03 
                 1.15 
                 0.717 
                 1700 
                 9.48E−03 
                 1.11 
                 0.71 
                 2034 
               
               
                 C05 
                 176640493 
                 rs7724098 
                 G 
                 0.289 
                 10627 
                 1.55E−03 
                 1.14 
                 0.317 
                 1697 
                 2.16E−03 
                 1.13 
                 0.314 
                 2031 
               
               
                 C03 
                 54346463 
                 rs1530733 
                 A 
                 0.156 
                 10635 
                 1.55E−03 
                 1.18 
                 0.179 
                 1700 
                 3.48E−03 
                 1.15 
                 0.176 
                 2034 
               
               
                 C16 
                 88263882 
                 rs904800 
                 G 
                 0.38 
                 10635 
                 1.55E−03 
                 1.14 
                 0.411 
                 1700 
                 5.04E−03 
                 1.11 
                 0.405 
                 2034 
               
               
                 C22 
                 34142107 
                 rs2071744 
                 C 
                 0.78 
                 10607 
                 1.55E−03 
                 1.17 
                 0.806 
                 1700 
                 5.19E−03 
                 1.13 
                 0.801 
                 2033 
               
               
                 C07 
                 136071365 
                 rs324594 
                 C 
                 0.27 
                 10632 
                 1.55E−03 
                 1.15 
                 0.298 
                 1700 
                 7.92E−04 
                 1.14 
                 0.297 
                 2034 
               
               
                 C07 
                 102722901 
                 rs10282605 
                 C 
                 0.187 
                 10633 
                 1.55E−03 
                 1.17 
                 0.211 
                 1700 
                 9.25E−03 
                 1.13 
                 0.206 
                 2034 
               
               
                 C04 
                 37546025 
                 rs3849018 
                 T 
                 0.279 
                 10635 
                 1.55E−03 
                 1.15 
                 0.307 
                 1700 
                 2.28E−03 
                 1.13 
                 0.304 
                 2033 
               
               
                 C05 
                 97972689 
                 rs168654 
                 T 
                 0.636 
                 10630 
                 1.56E−03 
                 1.14 
                 0.665 
                 1699 
                 5.48E−03 
                 1.11 
                 0.66 
                 2033 
               
               
                 C06 
                 28156603 
                 rs203877 
                 T 
                 0.729 
                 10461 
                 1.56E−03 
                 1.16 
                 0.757 
                 1666 
                 1.78E−02 
                 1.1 
                 0.748 
                 1992 
               
               
                 C05 
                 76862558 
                 rs251470 
                 T 
                 0.439 
                 10634 
                 1.56E−03 
                 1.13 
                 0.47 
                 1700 
                 6.26E−03 
                 1.11 
                 0.464 
                 2034 
               
               
                 C09 
                 122155539 
                 rs3780680 
                 T 
                 0.452 
                 10610 
                 1.56E−03 
                 1.13 
                 0.483 
                 1698 
                 2.92E−02 
                 1.08 
                 0.472 
                 2031 
               
               
                 C04 
                 10657250 
                 rs10011464 
                 T 
                 0.462 
                 10581 
                 1.56E−03 
                 1.13 
                 0.493 
                 1685 
                 2.56E−03 
                 1.12 
                 0.49 
                 2016 
               
               
                 C08 
                 143147459 
                 rs11167132 
                 T 
                 0.218 
                 10568 
                 1.57E−03 
                 1.16 
                 0.244 
                 1693 
                 3.04E−03 
                 1.14 
                 0.241 
                 2027 
               
               
                 CX 
                 66121372 
                 rs1576059 
                 T 
                 0.941 
                 8273 
                 1.57E−03 
                 1.43 
                 0.958 
                 1103 
                 9.27E−03 
                 1.31 
                 0.954 
                 1316 
               
               
                 C16 
                 82550760 
                 rs10514560 
                 C 
                 0.732 
                 10632 
                 1.57E−03 
                 1.15 
                 0.759 
                 1700 
                 2.17E−03 
                 1.14 
                 0.756 
                 2034 
               
               
                 C20 
                 57601797 
                 rs486921 
                 C 
                 0.853 
                 10634 
                 1.58E−03 
                 1.2 
                 0.875 
                 1699 
                 7.96E−04 
                 1.2 
                 0.875 
                 2033 
               
               
                 C17 
                 14301595 
                 rs2856177 
                 A 
                 0.622 
                 10630 
                 1.59E−03 
                 1.14 
                 0.652 
                 1700 
                 6.13E−03 
                 1.11 
                 0.647 
                 2034 
               
               
                 C01 
                 63947687 
                 rs2806535 
                 A 
                 0.487 
                 10630 
                 1.59E−03 
                 1.13 
                 0.519 
                 1700 
                 2.11E−03 
                 1.12 
                 0.515 
                 2034 
               
               
                 C22 
                 18426996 
                 rs3804044 
                 T 
                 0.858 
                 10612 
                 1.59E−03 
                 1.2 
                 0.879 
                 1700 
                 4.62E−03 
                 1.17 
                 0.876 
                 2034 
               
               
                 C19 
                 50054507 
                 rs377702 
                 T 
                 0.384 
                 10629 
                 1.61E−03 
                 1.14 
                 0.415 
                 1700 
                 1.75E−03 
                 1.12 
                 0.412 
                 2034 
               
               
                 C18 
                 55144365 
                 rs4806 
                 C 
                 0.284 
                 10592 
                 1.61E−03 
                 1.15 
                 0.312 
                 1686 
                 4.58E−03 
                 1.12 
                 0.307 
                 2020 
               
               
                 C08 
                 75320456 
                 rs4410896 
                 A 
                 0.479 
                 10635 
                 1.61E−03 
                 1.13 
                 0.51 
                 1700 
                 4.67E−04 
                 1.14 
                 0.511 
                 2034 
               
               
                 C13 
                 43040379 
                 rs963569 
                 A 
                 0.748 
                 10635 
                 1.61E−03 
                 1.16 
                 0.775 
                 1700 
                 4.72E−02 
                 1.09 
                 0.764 
                 2034 
               
               
                 CX 
                 69317680 
                 rs2341629 
                 C 
                 0.467 
                 8261 
                 1.62E−03 
                 1.16 
                 0.505 
                 1103 
                 1.66E−03 
                 1.15 
                 0.502 
                 1316 
               
               
                 C11 
                 17901963 
                 rs2237921 
                 C 
                 0.156 
                 10634 
                 1.62E−03 
                 1.18 
                 0.179 
                 1700 
                 6.00E−03 
                 1.14 
                 0.174 
                 2034 
               
               
                 C10 
                 84972068 
                 rs11199158 
                 G 
                 0.608 
                 10635 
                 1.62E−03 
                 1.14 
                 0.638 
                 1700 
                 2.26E−05 
                 1.17 
                 0.645 
                 2034 
               
               
                 C11 
                 1390257 
                 rs4963076 
                 T 
                 0.482 
                 10635 
                 1.62E−03 
                 1.13 
                 0.513 
                 1700 
                 3.68E−03 
                 1.11 
                 0.508 
                 2034 
               
               
                 C11 
                 1390257 
                 rs4963076 
                 T 
                 0.482 
                 10635 
                 1.62E−03 
                 1.13 
                 0.513 
                 1700 
                 3.68E−03 
                 1.11 
                 0.508 
                 2034 
               
               
                 C15 
                 52585989 
                 rs2553223 
                 G 
                 0.346 
                 10626 
                 1.62E−03 
                 1.14 
                 0.376 
                 1700 
                 6.64E−04 
                 1.14 
                 0.376 
                 2034 
               
               
                 C08 
                 32791061 
                 rs16880128 
                 G 
                 0.446 
                 10541 
                 1.63E−03 
                 1.13 
                 0.477 
                 1693 
                 9.35E−03 
                 1.1 
                 0.47 
                 2026 
               
               
                 C08 
                 96746644 
                 rs3134517 
                 G 
                 0.64 
                 10632 
                 1.63E−03 
                 1.14 
                 0.67 
                 1700 
                 7.83E−03 
                 1.11 
                 0.663 
                 2033 
               
               
                 C01 
                 55121739 
                 rs4927219 
                 G 
                 0.601 
                 10635 
                 1.63E−03 
                 1.14 
                 0.631 
                 1700 
                 3.78E−04 
                 1.14 
                 0.632 
                 2034 
               
               
                 C14 
                 19276803 
                 rs10872856 
                 C 
                 0.912 
                 10635 
                 1.63E−03 
                 1.26 
                 0.929 
                 1700 
                 1.56E−02 
                 1.18 
                 0.924 
                 2034 
               
               
                 C01 
                 148792338 
                 rs1970568 
                 T 
                 0.813 
                 10634 
                 1.64E−03 
                 1.18 
                 0.837 
                 1700 
                 2.08E−03 
                 1.16 
                 0.835 
                 2034 
               
               
                 C12 
                 20945636 
                 rs3764006 
                 C 
                 0.104 
                 10626 
                 1.64E−03 
                 1.21 
                 0.123 
                 1700 
                 8.33E−04 
                 1.21 
                 0.123 
                 2034 
               
               
                 C18 
                 45732885 
                 rs1557359 
                 G 
                 0.407 
                 10635 
                 1.64E−03 
                 1.13 
                 0.437 
                 1700 
                 1.64E−03 
                 1.12 
                 0.435 
                 2034 
               
               
                 C17 
                 14260485 
                 rs2323095 
                 A 
                 0.663 
                 10635 
                 1.64E−03 
                 1.14 
                 0.692 
                 1700 
                 3.76E−03 
                 1.12 
                 0.688 
                 2034 
               
               
                 C08 
                 96745945 
                 rs3102526 
                 G 
                 0.64 
                 10635 
                 1.65E−03 
                 1.14 
                 0.669 
                 1700 
                 7.97E−03 
                 1.11 
                 0.663 
                 2034 
               
               
                 C04 
                 96606254 
                 rs6850673 
                 C 
                 0.141 
                 10631 
                 1.65E−03 
                 1.19 
                 0.163 
                 1700 
                 2.15E−03 
                 1.17 
                 0.161 
                 2034 
               
               
                 C22 
                 18449129 
                 rs2073778 
                 C 
                 0.858 
                 10635 
                 1.65E−03 
                 1.2 
                 0.879 
                 1700 
                 5.41E−03 
                 1.16 
                 0.875 
                 2034 
               
               
                 C07 
                 116742325 
                 rs2027945 
                 A 
                 0.19 
                 10631 
                 1.66E−03 
                 1.17 
                 0.215 
                 1700 
                 1.06E−03 
                 1.16 
                 0.214 
                 2034 
               
               
                 C07 
                 144298585 
                 rs7791708 
                 A 
                 0.677 
                 10614 
                 1.66E−03 
                 1.14 
                 0.706 
                 1693 
                 4.26E−03 
                 1.12 
                 0.701 
                 2027 
               
               
                 C05 
                 3977821 
                 rs11956711 
                 C 
                 0.066 
                 10608 
                 1.66E−03 
                 1.26 
                 0.082 
                 1698 
                 4.36E−03 
                 1.22 
                 0.08 
                 2031 
               
               
                 C05 
                 39071087 
                 rs9292729 
                 C 
                 0.338 
                 10625 
                 1.66E−03 
                 1.14 
                 0.368 
                 1700 
                 6.86E−03 
                 1.11 
                 0.362 
                 2034 
               
               
                 C01 
                 29291511 
                 rs10799128 
                 T 
                 0.196 
                 10601 
                 1.66E−03 
                 1.16 
                 0.221 
                 1686 
                 3.50E−03 
                 1.14 
                 0.217 
                 2020 
               
               
                 C05 
                 3595286 
                 rs1697997 
                 A 
                 0.914 
                 10635 
                 1.66E−03 
                 1.26 
                 0.931 
                 1700 
                 5.14E−03 
                 1.21 
                 0.928 
                 2034 
               
               
                 C02 
                 215347262 
                 rs10932529 
                 A 
                 0.247 
                 10635 
                 1.67E−03 
                 1.15 
                 0.274 
                 1700 
                 1.88E−03 
                 1.14 
                 0.272 
                 2034 
               
               
                 CX 
                 6130802 
                 rs7892324 
                 C 
                 0.165 
                 8255 
                 1.67E−03 
                 1.22 
                 0.194 
                 1093 
                 3.38E−03 
                 1.19 
                 0.19 
                 1306 
               
               
                 C12 
                 62930978 
                 rs10878126 
                 G 
                 0.493 
                 10634 
                 1.67E−03 
                 1.13 
                 0.524 
                 1700 
                 6.47E−04 
                 1.13 
                 0.525 
                 2034 
               
               
                 C04 
                 44935711 
                 rs6447404 
                 G 
                 0.617 
                 10633 
                 1.67E−03 
                 1.14 
                 0.647 
                 1700 
                 1.07E−02 
                 1.1 
                 0.639 
                 2034 
               
               
                 C03 
                 145977000 
                 rs10935523 
                 A 
                 0.741 
                 10632 
                 1.68E−03 
                 1.16 
                 0.767 
                 1700 
                 7.37E−03 
                 1.12 
                 0.762 
                 2034 
               
               
                 C16 
                 79586916 
                 rs7188879 
                 T 
                 0.964 
                 10629 
                 1.69E−03 
                 1.45 
                 0.975 
                 1699 
                 7.87E−03 
                 1.33 
                 0.972 
                 2033 
               
               
                 C05 
                 159076573 
                 rs889053 
                 T 
                 0.162 
                 10634 
                 1.69E−03 
                 1.18 
                 0.185 
                 1700 
                 3.69E−03 
                 1.15 
                 0.182 
                 2034 
               
               
                 C11 
                 91175735 
                 rs808003 
                 T 
                 0.554 
                 10634 
                 1.69E−03 
                 1.13 
                 0.585 
                 1700 
                 2.62E−02 
                 1.09 
                 0.574 
                 2034 
               
               
                 C17 
                 14258654 
                 rs12449610 
                 T 
                 0.669 
                 10635 
                 1.69E−03 
                 1.14 
                 0.697 
                 1700 
                 3.74E−03 
                 1.12 
                 0.693 
                 2034 
               
               
                 C04 
                 3811449 
                 rs6822427 
                 A 
                 0.487 
                 10635 
                 1.70E−03 
                 1.13 
                 0.518 
                 1700 
                 2.14E−03 
                 1.12 
                 0.515 
                 2034 
               
               
                 C01 
                 218934430 
                 rs1519463 
                 G 
                 0.5 
                 10635 
                 1.70E−03 
                 1.13 
                 0.531 
                 1700 
                 4.65E−04 
                 1.14 
                 0.532 
                 2034 
               
               
                 C02 
                 183549717 
                 rs4666836 
                 T 
                 0.22 
                 10633 
                 1.70E−03 
                 1.16 
                 0.246 
                 1699 
                 3.72E−03 
                 1.13 
                 0.242 
                 2033 
               
               
                 C03 
                 62438401 
                 rs1452075 
                 T 
                 0.734 
                 10549 
                 1.70E−03 
                 1.15 
                 0.761 
                 1692 
                 5.65E−03 
                 1.12 
                 0.756 
                 2019 
               
               
                 C03 
                 62438401 
                 rs1452075 
                 T 
                 0.734 
                 10549 
                 1.70E−03 
                 1.15 
                 0.761 
                 1692 
                 5.65E−03 
                 1.12 
                 0.756 
                 2019 
               
               
                 C10 
                 15387774 
                 rs2138930 
                 T 
                 0.11 
                 10620 
                 1.71E−03 
                 1.21 
                 0.129 
                 1700 
                 8.36E−03 
                 1.16 
                 0.125 
                 2033 
               
               
                 C12 
                 6177827 
                 rs797773 
                 T 
                 0.394 
                 10607 
                 1.71E−03 
                 1.13 
                 0.425 
                 1698 
                 2.20E−03 
                 1.12 
                 0.422 
                 2031 
               
               
                 C12 
                 52152886 
                 rs784563 
                 G 
                 0.441 
                 10631 
                 1.71E−03 
                 1.13 
                 0.472 
                 1700 
                 1.70E−03 
                 1.12 
                 0.47 
                 2034 
               
               
                 C01 
                 113143551 
                 rs773588 
                 C 
                 0.276 
                 10632 
                 1.71E−03 
                 1.15 
                 0.304 
                 1700 
                 2.18E−04 
                 1.16 
                 0.307 
                 2034 
               
               
                 C05 
                 66177928 
                 rs39700 
                 G 
                 0.374 
                 10631 
                 1.72E−03 
                 1.13 
                 0.404 
                 1699 
                 1.04E−02 
                 1.1 
                 0.396 
                 2033 
               
               
                 C11 
                 132266819 
                 rs1395504 
                 A 
                 0.493 
                 10634 
                 1.72E−03 
                 1.13 
                 0.524 
                 1700 
                 3.66E−03 
                 1.11 
                 0.519 
                 2034 
               
               
                 C18 
                 70236272 
                 rs1365254 
                 T 
                 0.192 
                 10634 
                 1.73E−03 
                 1.16 
                 0.217 
                 1700 
                 1.01E−03 
                 1.16 
                 0.216 
                 2034 
               
               
                 C05 
                 38927129 
                 rs525735 
                 C 
                 0.774 
                 10632 
                 1.74E−03 
                 1.16 
                 0.799 
                 1699 
                 1.06E−02 
                 1.12 
                 0.793 
                 2033 
               
               
                 C08 
                 75357793 
                 rs10283076 
                 G 
                 0.477 
                 10627 
                 1.74E−03 
                 1.13 
                 0.507 
                 1698 
                 3.56E−04 
                 1.14 
                 0.509 
                 2032 
               
               
                 C10 
                 108671040 
                 rs1337430 
                 A 
                 0.788 
                 10215 
                 1.74E−03 
                 1.17 
                 0.813 
                 1685 
                 9.30E−03 
                 1.13 
                 0.807 
                 2014 
               
               
                 C18 
                 55191365 
                 rs9319948 
                 A 
                 0.283 
                 10629 
                 1.75E−03 
                 1.14 
                 0.311 
                 1700 
                 4.57E−03 
                 1.12 
                 0.306 
                 2034 
               
               
                 C15 
                 30230982 
                 rs4779984 
                 G 
                 0.1 
                 10616 
                 1.75E−03 
                 1.22 
                 0.119 
                 1698 
                 9.51E−04 
                 1.21 
                 0.119 
                 2032 
               
               
                 C10 
                 33672138 
                 rs2804453 
                 G 
                 0.111 
                 10621 
                 1.76E−03 
                 1.21 
                 0.131 
                 1697 
                 8.26E−03 
                 1.16 
                 0.126 
                 2030 
               
               
                 C21 
                 40710416 
                 rs1882757 
                 A 
                 0.506 
                 10635 
                 1.76E−03 
                 1.13 
                 0.536 
                 1700 
                 2.56E−03 
                 1.12 
                 0.533 
                 2034 
               
               
                 C06 
                 39827103 
                 rs9471170 
                 G 
                 0.885 
                 10635 
                 1.77E−03 
                 1.22 
                 0.904 
                 1700 
                 1.10E−02 
                 1.16 
                 0.899 
                 2034 
               
               
                 C09 
                 28154645 
                 rs2044961 
                 G 
                 0.571 
                 10633 
                 1.77E−03 
                 1.13 
                 0.601 
                 1700 
                 7.85E−04 
                 1.13 
                 0.601 
                 2034 
               
               
                 C10 
                 94841520 
                 rs10509657 
                 C 
                 0.099 
                 10631 
                 1.78E−03 
                 1.22 
                 0.118 
                 1700 
                 3.06E−03 
                 1.19 
                 0.115 
                 2034 
               
               
                 C12 
                 101677726 
                 rs2247919 
                 T 
                 0.738 
                 10635 
                 1.79E−03 
                 1.15 
                 0.764 
                 1700 
                 6.44E−03 
                 1.12 
                 0.759 
                 2034 
               
               
                 C02 
                 11287711 
                 rs7608117 
                 T 
                 0.486 
                 10629 
                 1.79E−03 
                 1.13 
                 0.517 
                 1698 
                 4.79E−03 
                 1.11 
                 0.512 
                 2031 
               
               
                 C01 
                 31037636 
                 rs12126748 
                 A 
                 0.345 
                 10489 
                 1.79E−03 
                 1.14 
                 0.375 
                 1665 
                 5.15E−03 
                 1.11 
                 0.37 
                 1995 
               
               
                 C03 
                 63602103 
                 rs7653410 
                 C 
                 0.319 
                 10620 
                 1.79E−03 
                 1.14 
                 0.348 
                 1700 
                 1.04E−02 
                 1.1 
                 0.341 
                 2034 
               
               
                 C17 
                 70788248 
                 rs2041088 
                 A 
                 0.719 
                 10633 
                 1.79E−03 
                 1.15 
                 0.747 
                 1700 
                 3.91E−03 
                 1.13 
                 0.743 
                 2034 
               
               
                 C06 
                 36751662 
                 rs1864750 
                 G 
                 0.248 
                 10635 
                 1.80E−03 
                 1.15 
                 0.275 
                 1700 
                 2.56E−04 
                 1.16 
                 0.277 
                 2034 
               
               
                 C11 
                 12971706 
                 rs3935878 
                 T 
                 0.738 
                 10634 
                 1.80E−03 
                 1.15 
                 0.764 
                 1700 
                 5.90E−03 
                 1.12 
                 0.76 
                 2034 
               
               
                 C12 
                 67493429 
                 rs1470383 
                 C 
                 0.143 
                 10634 
                 1.81E−03 
                 1.18 
                 0.165 
                 1700 
                 3.15E−03 
                 1.16 
                 0.162 
                 2034 
               
               
                 C05 
                 56037706 
                 rs7720499 
                 T 
                 0.112 
                 10635 
                 1.81E−03 
                 1.2 
                 0.132 
                 1700 
                 3.98E−03 
                 1.17 
                 0.129 
                 2033 
               
               
                 C02 
                 172714469 
                 rs951917 
                 T 
                 0.387 
                 10634 
                 1.83E−03 
                 1.13 
                 0.417 
                 1700 
                 1.00E−02 
                 1.1 
                 0.41 
                 2034 
               
               
                 C03 
                 6764265 
                 rs12491369 
                 G 
                 0.571 
                 10634 
                 1.83E−03 
                 1.13 
                 0.601 
                 1700 
                 9.89E−04 
                 1.13 
                 0.601 
                 2034 
               
               
                 C06 
                 79771759 
                 rs9352688 
                 A 
                 0.623 
                 10384 
                 1.83E−03 
                 1.14 
                 0.653 
                 1662 
                 2.17E−03 
                 1.12 
                 0.65 
                 1991 
               
               
                 C19 
                 446722 
                 rs758503 
                 T 
                 0.294 
                 10524 
                 1.83E−03 
                 1.14 
                 0.323 
                 1686 
                 3.19E−03 
                 1.12 
                 0.319 
                 2018 
               
               
                 C03 
                 74187210 
                 rs4234186 
                 A 
                 0.943 
                 10617 
                 1.83E−03 
                 1.33 
                 0.957 
                 1697 
                 8.06E−03 
                 1.25 
                 0.954 
                 2031 
               
               
                 C07 
                 16590961 
                 rs706076 
                 G 
                 0.146 
                 10619 
                 1.83E−03 
                 1.18 
                 0.169 
                 1700 
                 1.53E−02 
                 1.13 
                 0.162 
                 2034 
               
               
                 C02 
                 76317619 
                 rs7563058 
                 C 
                 0.504 
                 10635 
                 1.84E−03 
                 1.13 
                 0.535 
                 1700 
                 2.64E−03 
                 1.12 
                 0.531 
                 2034 
               
               
                 C04 
                 175513600 
                 rs4695894 
                 G 
                 0.5 
                 10632 
                 1.84E−03 
                 1.13 
                 0.53 
                 1700 
                 2.89E−03 
                 1.11 
                 0.527 
                 2034 
               
               
                 C17 
                 18352177 
                 rs2746025 
                 G 
                 0.641 
                 10635 
                 1.84E−03 
                 1.14 
                 0.671 
                 1700 
                 2.07E−03 
                 1.13 
                 0.668 
                 2034 
               
               
                 C07 
                 28337194 
                 rs10486588 
                 G 
                 0.231 
                 10616 
                 1.85E−03 
                 1.15 
                 0.258 
                 1694 
                 3.86E−03 
                 1.13 
                 0.254 
                 2028 
               
               
                 C06 
                 39793734 
                 rs9296304 
                 A 
                 0.498 
                 10635 
                 1.85E−03 
                 1.13 
                 0.529 
                 1700 
                 9.98E−03 
                 1.1 
                 0.521 
                 2034 
               
               
                 C13 
                 20599475 
                 rs4770252 
                 A 
                 0.802 
                 10626 
                 1.86E−03 
                 1.17 
                 0.826 
                 1699 
                 4.75E−04 
                 1.18 
                 0.827 
                 2032 
               
               
                 C04 
                 178964553 
                 rs1983130 
                 G 
                 0.414 
                 10625 
                 1.86E−03 
                 1.13 
                 0.444 
                 1699 
                 3.12E−03 
                 1.12 
                 0.441 
                 2033 
               
               
                 C02 
                 39306628 
                 rs2168043 
                 C 
                 0.868 
                 10635 
                 1.86E−03 
                 1.21 
                 0.888 
                 1700 
                 2.99E−03 
                 1.18 
                 0.886 
                 2034 
               
               
                 C06 
                 105791384 
                 rs1149305 
                 T 
                 0.059 
                 10544 
                 1.87E−03 
                 1.28 
                 0.074 
                 1695 
                 1.49E−03 
                 1.26 
                 0.074 
                 2027 
               
               
                 C22 
                 18432012 
                 rs5992507 
                 A 
                 0.858 
                 10633 
                 1.87E−03 
                 1.2 
                 0.879 
                 1700 
                 5.40E−03 
                 1.16 
                 0.876 
                 2034 
               
               
                 C13 
                 53208642 
                 rs2050972 
                 C 
                 0.878 
                 10635 
                 1.87E−03 
                 1.22 
                 0.897 
                 1700 
                 6.10E−03 
                 1.17 
                 0.894 
                 2034 
               
               
                 C03 
                 66633156 
                 rs1563545 
                 G 
                 0.523 
                 10562 
                 1.87E−03 
                 1.13 
                 0.553 
                 1681 
                 2.31E−03 
                 1.12 
                 0.55 
                 2014 
               
               
                 C03 
                 7494813 
                 rs752299 
                 T 
                 0.685 
                 10633 
                 1.87E−03 
                 1.14 
                 0.714 
                 1700 
                 3.80E−03 
                 1.12 
                 0.71 
                 2034 
               
               
                 C01 
                 173267354 
                 rs12033847 
                 T 
                 0.462 
                 10416 
                 1.88E−03 
                 1.13 
                 0.493 
                 1668 
                 2.13E−03 
                 1.12 
                 0.49 
                 1988 
               
               
                 C07 
                 147146014 
                 rs10271435 
                 A 
                 0.06 
                 10631 
                 1.88E−03 
                 1.27 
                 0.076 
                 1700 
                 2.74E−04 
                 1.3 
                 0.077 
                 2034 
               
               
                 C03 
                 29295798 
                 rs13079598 
                 A 
                 0.905 
                 10635 
                 1.88E−03 
                 1.25 
                 0.923 
                 1700 
                 5.92E−03 
                 1.2 
                 0.92 
                 2034 
               
               
                 CX 
                 143133206 
                 rs11094472 
                 G 
                 0.787 
                 8262 
                 1.89E−03 
                 1.21 
                 0.817 
                 1098 
                 3.45E−03 
                 1.18 
                 0.814 
                 1311 
               
               
                 C07 
                 116708662 
                 rs2237724 
                 A 
                 0.19 
                 10635 
                 1.90E−03 
                 1.16 
                 0.215 
                 1700 
                 1.21E−03 
                 1.16 
                 0.214 
                 2034 
               
               
                 C07 
                 116694598 
                 rs10487368 
                 T 
                 0.19 
                 10635 
                 1.90E−03 
                 1.16 
                 0.215 
                 1700 
                 1.21E−03 
                 1.16 
                 0.214 
                 2034 
               
               
                 C07 
                 116702050 
                 rs2237723 
                 T 
                 0.193 
                 10630 
                 1.90E−03 
                 1.16 
                 0.217 
                 1700 
                 1.05E−03 
                 1.16 
                 0.217 
                 2034 
               
               
                 C02 
                 173071729 
                 rs6718013 
                 G 
                 0.538 
                 10634 
                 1.91E−03 
                 1.13 
                 0.568 
                 1700 
                 1.45E−02 
                 1.09 
                 0.56 
                 2034 
               
               
                 C03 
                 7486375 
                 rs779710 
                 A 
                 0.589 
                 10634 
                 1.91E−03 
                 1.13 
                 0.619 
                 1700 
                 1.47E−03 
                 1.13 
                 0.617 
                 2034 
               
               
                 C07 
                 38853360 
                 rs1525798 
                 G 
                 0.303 
                 10635 
                 1.91E−03 
                 1.14 
                 0.331 
                 1700 
                 1.23E−03 
                 1.13 
                 0.33 
                 2034 
               
               
                 C18 
                 53741253 
                 rs4940582 
                 G 
                 0.849 
                 10631 
                 1.91E−03 
                 1.19 
                 0.871 
                 1699 
                 1.77E−03 
                 1.18 
                 0.869 
                 2033 
               
               
                 C04 
                 161577318 
                 rs17326199 
                 G 
                 0.211 
                 10634 
                 1.91E−03 
                 1.16 
                 0.237 
                 1699 
                 8.27E−03 
                 1.12 
                 0.231 
                 2033 
               
               
                 C13 
                 20622774 
                 rs9285207 
                 C 
                 0.195 
                 10608 
                 1.91E−03 
                 1.16 
                 0.22 
                 1693 
                 1.89E−03 
                 1.15 
                 0.218 
                 2026 
               
               
                 C08 
                 75316641 
                 rs10504576 
                 A 
                 0.478 
                 10551 
                 1.92E−03 
                 1.13 
                 0.509 
                 1677 
                 5.94E−04 
                 1.13 
                 0.51 
                 2010 
               
               
                 C14 
                 92766673 
                 rs2281519 
                 T 
                 0.257 
                 10633 
                 1.92E−03 
                 1.15 
                 0.284 
                 1700 
                 5.98E−03 
                 1.12 
                 0.279 
                 2033 
               
               
                 C15 
                 37096582 
                 rs1841441 
                 A 
                 0.466 
                 10634 
                 1.92E−03 
                 1.13 
                 0.496 
                 1700 
                 1.15E−03 
                 1.13 
                 0.496 
                 2034 
               
               
                 C10 
                 84843813 
                 rs2349157 
                 G 
                 0.855 
                 10635 
                 1.93E−03 
                 1.2 
                 0.876 
                 1700 
                 9.76E−04 
                 1.19 
                 0.876 
                 2034 
               
               
                 C05 
                 167524725 
                 rs2617972 
                 C 
                 0.808 
                 10632 
                 1.93E−03 
                 1.17 
                 0.832 
                 1699 
                 9.94E−03 
                 1.13 
                 0.827 
                 2033 
               
               
                 C12 
                 96022770 
                 rs989264 
                 A 
                 0.041 
                 10635 
                 1.93E−03 
                 1.33 
                 0.054 
                 1700 
                 1.86E−03 
                 1.31 
                 0.053 
                 2034 
               
               
                 C06 
                 10958298 
                 rs9357002 
                 T 
                 0.631 
                 10453 
                 1.93E−03 
                 1.14 
                 0.66 
                 1678 
                 4.72E−03 
                 1.11 
                 0.655 
                 2007 
               
               
                 C04 
                 147453178 
                 rs723794 
                 T 
                 0.764 
                 10635 
                 1.94E−03 
                 1.16 
                 0.79 
                 1700 
                 5.53E−03 
                 1.13 
                 0.785 
                 2034 
               
               
                 C11 
                 127732102 
                 rs7933433 
                 G 
                 0.648 
                 10633 
                 1.95E−03 
                 1.14 
                 0.677 
                 1699 
                 1.69E−03 
                 1.13 
                 0.675 
                 2033 
               
               
                 C03 
                 5243162 
                 rs341973 
                 A 
                 0.51 
                 10634 
                 1.95E−03 
                 1.13 
                 0.541 
                 1700 
                 1.92E−02 
                 1.09 
                 0.531 
                 2034 
               
               
                 C22 
                 18482283 
                 rs2238798 
                 G 
                 0.858 
                 10633 
                 1.95E−03 
                 1.2 
                 0.879 
                 1700 
                 6.39E−03 
                 1.16 
                 0.875 
                 2034 
               
               
                 C10 
                 65928341 
                 rs990828 
                 G 
                 0.416 
                 10631 
                 1.96E−03 
                 1.13 
                 0.446 
                 1700 
                 1.23E−02 
                 1.1 
                 0.438 
                 2034 
               
               
                 C08 
                 143121983 
                 rs7834060 
                 G 
                 0.434 
                 10635 
                 1.96E−03 
                 1.13 
                 0.464 
                 1700 
                 2.51E−03 
                 1.12 
                 0.461 
                 2034 
               
               
                 C01 
                 184791657 
                 rs1339083 
                 A 
                 0.34 
                 10635 
                 1.96E−03 
                 1.14 
                 0.369 
                 1700 
                 1.56E−03 
                 1.13 
                 0.367 
                 2034 
               
               
                 C11 
                 92444704 
                 rs9971402 
                 C 
                 0.872 
                 10633 
                 1.96E−03 
                 1.21 
                 0.892 
                 1700 
                 5.09E−04 
                 1.22 
                 0.893 
                 2034 
               
               
                 C04 
                 162770424 
                 rs958247 
                 A 
                 0.287 
                 10626 
                 1.96E−03 
                 1.14 
                 0.315 
                 1700 
                 1.64E−03 
                 1.13 
                 0.314 
                 2034 
               
               
                 C07 
                 150069821 
                 rs2373885 
                 A 
                 0.75 
                 10631 
                 1.96E−03 
                 1.16 
                 0.776 
                 1700 
                 8.98E−04 
                 1.15 
                 0.776 
                 2034 
               
               
                 C08 
                 139195557 
                 rs4909759 
                 T 
                 0.261 
                 10633 
                 1.96E−03 
                 1.15 
                 0.288 
                 1700 
                 7.46E−03 
                 1.12 
                 0.282 
                 2034 
               
               
                 C02 
                 209737500 
                 rs9288396 
                 T 
                 0.204 
                 10635 
                 1.97E−03 
                 1.16 
                 0.229 
                 1700 
                 1.09E−03 
                 1.15 
                 0.229 
                 2034 
               
               
                 C01 
                 40520068 
                 rs7524868 
                 G 
                 0.306 
                 10611 
                 1.97E−03 
                 1.14 
                 0.334 
                 1691 
                 3.27E−02 
                 1.09 
                 0.324 
                 2024 
               
               
                 C06 
                 79657373 
                 rs10943606 
                 G 
                 0.746 
                 10632 
                 1.97E−03 
                 1.15 
                 0.772 
                 1700 
                 1.90E−03 
                 1.14 
                 0.771 
                 2033 
               
               
                 C16 
                 2014037 
                 rs3785284 
                 C 
                 0.265 
                 10571 
                 1.98E−03 
                 1.15 
                 0.292 
                 1698 
                 2.17E−03 
                 1.13 
                 0.29 
                 2032 
               
               
                 C02 
                 215385419 
                 rs2216544 
                 A 
                 0.253 
                 10635 
                 1.98E−03 
                 1.15 
                 0.28 
                 1700 
                 2.46E−03 
                 1.13 
                 0.278 
                 2034 
               
               
                 C17 
                 53871788 
                 rs9895713 
                 G 
                 0.176 
                 10633 
                 1.98E−03 
                 1.17 
                 0.2 
                 1700 
                 2.03E−03 
                 1.15 
                 0.198 
                 2034 
               
               
                 C03 
                 2631107 
                 rs17565216 
                 C 
                 0.363 
                 10631 
                 1.98E−03 
                 1.13 
                 0.392 
                 1699 
                 9.20E−04 
                 1.13 
                 0.392 
                 2033 
               
               
                 C07 
                 116815796 
                 rs213987 
                 T 
                 0.327 
                 10632 
                 1.99E−03 
                 1.14 
                 0.356 
                 1700 
                 3.83E−03 
                 1.12 
                 0.352 
                 2034 
               
               
                 C07 
                 116815796 
                 rs213987 
                 T 
                 0.327 
                 10632 
                 1.99E−03 
                 1.14 
                 0.356 
                 1700 
                 3.83E−03 
                 1.12 
                 0.352 
                 2034 
               
               
                 C03 
                 175238582 
                 rs1549100 
                 T 
                 0.73 
                 10574 
                 1.99E−03 
                 1.15 
                 0.757 
                 1693 
                 3.92E−02 
                 1.09 
                 0.747 
                 2026 
               
               
                 C06 
                 69212746 
                 rs9454539 
                 A 
                 0.877 
                 10630 
                 1.99E−03 
                 1.21 
                 0.896 
                 1699 
                 9.23E−04 
                 1.21 
                 0.896 
                 2033 
               
               
                 C01 
                 65243954 
                 rs3818513 
                 C 
                 0.457 
                 10635 
                 1.99E−03 
                 1.13 
                 0.488 
                 1700 
                 5.23E−02 
                 1.07 
                 0.475 
                 2034 
               
               
                 C12 
                 123074369 
                 rs4765477 
                 T 
                 0.044 
                 10632 
                 1.99E−03 
                 1.32 
                 0.057 
                 1700 
                 3.78E−03 
                 1.27 
                 0.056 
                 2034 
               
               
                 C02 
                 118543519 
                 rs1477451 
                 T 
                 0.124 
                 10635 
                 2.00E−03 
                 1.19 
                 0.145 
                 1700 
                 2.98E−02 
                 1.12 
                 0.137 
                 2034 
               
               
                 C08 
                 143128135 
                 rs3934930 
                 T 
                 0.433 
                 10635 
                 2.00E−03 
                 1.13 
                 0.464 
                 1700 
                 2.52E−03 
                 1.12 
                 0.461 
                 2034 
               
               
                 C07 
                 81287212 
                 rs6467882 
                 C 
                 0.165 
                 10631 
                 2.00E−03 
                 1.17 
                 0.188 
                 1700 
                 1.69E−03 
                 1.16 
                 0.187 
                 2034 
               
               
                 C01 
                 155206460 
                 rs4971177 
                 T 
                 0.913 
                 10634 
                 2.00E−03 
                 1.26 
                 0.93 
                 1700 
                 8.85E−04 
                 1.26 
                 0.93 
                 2034 
               
               
                 C06 
                 119414590 
                 rs1360782 
                 A 
                 0.348 
                 10634 
                 2.01E−03 
                 1.13 
                 0.378 
                 1700 
                 1.44E−03 
                 1.13 
                 0.376 
                 2034 
               
               
                 C07 
                 50023386 
                 rs12669163 
                 C 
                 0.297 
                 10525 
                 2.01E−03 
                 1.14 
                 0.325 
                 1675 
                 5.51E−03 
                 1.12 
                 0.321 
                 2004 
               
               
                 C07 
                 16810246 
                 rs1029577 
                 T 
                 0.319 
                 10625 
                 2.02E−03 
                 1.14 
                 0.347 
                 1697 
                 2.55E−03 
                 1.12 
                 0.345 
                 2031 
               
               
                 C04 
                 82277070 
                 rs10026120 
                 T 
                 0.96 
                 10616 
                 2.03E−03 
                 1.4 
                 0.971 
                 1699 
                 7.73E−03 
                 1.31 
                 0.969 
                 2029 
               
               
                 C05 
                 133913277 
                 rs1476097 
                 T 
                 0.656 
                 10629 
                 2.03E−03 
                 1.14 
                 0.685 
                 1699 
                 4.64E−04 
                 1.15 
                 0.686 
                 2032 
               
               
                 C07 
                 13679025 
                 rs3735344 
                 G 
                 0.421 
                 10583 
                 2.04E−03 
                 1.13 
                 0.451 
                 1687 
                 7.75E−03 
                 1.1 
                 0.445 
                 2021 
               
               
                 C17 
                 7878493 
                 rs4791759 
                 A 
                 0.038 
                 10621 
                 2.05E−03 
                 1.34 
                 0.051 
                 1699 
                 5.53E−03 
                 1.28 
                 0.048 
                 2031 
               
               
                 C05 
                 14319911 
                 rs30616 
                 T 
                 0.852 
                 10634 
                 2.05E−03 
                 1.19 
                 0.873 
                 1700 
                 4.29E−03 
                 1.16 
                 0.87 
                 2034 
               
               
                 C06 
                 143011798 
                 rs478884 
                 A 
                 0.879 
                 10635 
                 2.05E−03 
                 1.22 
                 0.898 
                 1700 
                 7.23E−04 
                 1.22 
                 0.898 
                 2034 
               
               
                 C14 
                 47996364 
                 rs12436454 
                 T 
                 0.713 
                 10592 
                 2.05E−03 
                 1.15 
                 0.74 
                 1697 
                 4.47E−03 
                 1.12 
                 0.736 
                 2030 
               
               
                 C09 
                 23762277 
                 rs7038525 
                 T 
                 0.152 
                 10629 
                 2.05E−03 
                 1.18 
                 0.174 
                 1700 
                 4.27E−04 
                 1.19 
                 0.176 
                 2034 
               
               
                 C06 
                 69230698 
                 rs10806602 
                 T 
                 0.877 
                 10614 
                 2.06E−03 
                 1.21 
                 0.897 
                 1696 
                 1.03E−03 
                 1.21 
                 0.897 
                 2030 
               
               
                 C11 
                 17918391 
                 rs3993323 
                 A 
                 0.14 
                 10630 
                 2.06E−03 
                 1.18 
                 0.162 
                 1697 
                 5.18E−03 
                 1.15 
                 0.159 
                 2031 
               
               
                 C18 
                 35157614 
                 rs12964741 
                 A 
                 0.667 
                 10489 
                 2.06E−03 
                 1.14 
                 0.695 
                 1671 
                 3.40E−04 
                 1.15 
                 0.698 
                 2002 
               
               
                 C08 
                 73289641 
                 rs10504537 
                 A 
                 0.879 
                 10635 
                 2.08E−03 
                 1.22 
                 0.899 
                 1700 
                 4.08E−04 
                 1.23 
                 0.9 
                 2034 
               
               
                 C06 
                 72275474 
                 rs12207816 
                 A 
                 0.914 
                 10635 
                 2.08E−03 
                 1.26 
                 0.93 
                 1700 
                 7.95E−04 
                 1.26 
                 0.93 
                 2034 
               
               
                 C19 
                 4202069 
                 rs1045750 
                 C 
                 0.265 
                 10634 
                 2.08E−03 
                 1.14 
                 0.292 
                 1699 
                 6.95E−03 
                 1.12 
                 0.287 
                 2033 
               
               
                 C02 
                 203864322 
                 rs6704822 
                 G 
                 0.912 
                 10558 
                 2.08E−03 
                 1.26 
                 0.929 
                 1689 
                 3.09E−03 
                 1.22 
                 0.927 
                 2019 
               
               
                 C01 
                 173423432 
                 rs2175177 
                 A 
                 0.465 
                 10625 
                 2.09E−03 
                 1.13 
                 0.495 
                 1698 
                 1.84E−03 
                 1.12 
                 0.493 
                 2031 
               
               
                 CX 
                 115198464 
                 rs2526763 
                 G 
                 0.365 
                 8266 
                 2.09E−03 
                 1.17 
                 0.401 
                 1102 
                 7.05E−03 
                 1.13 
                 0.394 
                 1315 
               
               
                 C11 
                 134180799 
                 rs1289455 
                 T 
                 0.147 
                 10628 
                 2.09E−03 
                 1.18 
                 0.169 
                 1698 
                 2.49E−03 
                 1.16 
                 0.167 
                 2032 
               
               
                 C01 
                 238623817 
                 rs3014559 
                 A 
                 0.546 
                 10632 
                 2.10E−03 
                 1.13 
                 0.576 
                 1700 
                 2.98E−03 
                 1.12 
                 0.573 
                 2034 
               
               
                 C02 
                 76254681 
                 rs317285 
                 A 
                 0.504 
                 10634 
                 2.10E−03 
                 1.13 
                 0.534 
                 1700 
                 2.98E−03 
                 1.11 
                 0.531 
                 2034 
               
               
                 C08 
                 37465414 
                 rs7017907 
                 C 
                 0.083 
                 10598 
                 2.10E−03 
                 1.23 
                 0.101 
                 1691 
                 6.65E−03 
                 1.19 
                 0.098 
                 2024 
               
               
                 C16 
                 53597062 
                 rs3751812 
                 T 
                 0.404 
                 10627 
                 2.10E−03 
                 1.13 
                 0.433 
                 1699 
                 3.87E−04 
                 1.14 
                 0.436 
                 2033 
               
               
                 C05 
                 167526920 
                 rs1077046 
                 C 
                 0.553 
                 10633 
                 2.10E−03 
                 1.13 
                 0.583 
                 1700 
                 1.46E−02 
                 1.09 
                 0.575 
                 2034 
               
               
                 C10 
                 131748188 
                 rs11597160 
                 A 
                 0.906 
                 10635 
                 2.11E−03 
                 1.25 
                 0.923 
                 1700 
                 1.05E−02 
                 1.18 
                 0.919 
                 2034 
               
               
                 C18 
                 13442635 
                 rs12964045 
                 C 
                 0.13 
                 10634 
                 2.11E−03 
                 1.19 
                 0.151 
                 1700 
                 8.59E−03 
                 1.15 
                 0.147 
                 2034 
               
               
                 C05 
                 9694366 
                 rs3213627 
                 T 
                 0.167 
                 10630 
                 2.13E−03 
                 1.17 
                 0.19 
                 1700 
                 4.17E−03 
                 1.15 
                 0.187 
                 2034 
               
               
                 C21 
                 24693776 
                 rs2829040 
                 A 
                 0.449 
                 10633 
                 2.13E−03 
                 1.13 
                 0.479 
                 1700 
                 1.51E−03 
                 1.12 
                 0.478 
                 2034 
               
               
                 C07 
                 85269850 
                 rs1012995 
                 C 
                 0.219 
                 10600 
                 2.13E−03 
                 1.15 
                 0.244 
                 1685 
                 1.45E−03 
                 1.15 
                 0.243 
                 2019 
               
               
                 C07 
                 18443601 
                 rs2269752 
                 C 
                 0.93 
                 10630 
                 2.13E−03 
                 1.29 
                 0.944 
                 1700 
                 8.19E−03 
                 1.22 
                 0.941 
                 2034 
               
               
                 C01 
                 85995056 
                 rs1360903 
                 G 
                 0.511 
                 10626 
                 2.14E−03 
                 1.13 
                 0.541 
                 1700 
                 5.66E−03 
                 1.11 
                 0.536 
                 2033 
               
               
                 C16 
                 62628004 
                 rs2962080 
                 G 
                 0.609 
                 10631 
                 2.15E−03 
                 1.13 
                 0.638 
                 1699 
                 2.28E−03 
                 1.12 
                 0.636 
                 2033 
               
               
                 C12 
                 20081535 
                 rs2417821 
                 T 
                 0.749 
                 10635 
                 2.15E−03 
                 1.15 
                 0.775 
                 1700 
                 1.80E−04 
                 1.18 
                 0.778 
                 2034 
               
               
                 C04 
                 10634963 
                 rs2170752 
                 T 
                 0.576 
                 10634 
                 2.16E−03 
                 1.13 
                 0.606 
                 1700 
                 2.79E−02 
                 1.09 
                 0.596 
                 2034 
               
               
                 C09 
                 110310944 
                 rs4979085 
                 T 
                 0.297 
                 10629 
                 2.16E−03 
                 1.14 
                 0.324 
                 1700 
                 2.97E−03 
                 1.12 
                 0.322 
                 2034 
               
               
                 C01 
                 216145811 
                 rs11118175 
                 G 
                 0.076 
                 10635 
                 2.16E−03 
                 1.24 
                 0.092 
                 1700 
                 2.03E−03 
                 1.22 
                 0.091 
                 2034 
               
               
                 C06 
                 57080845 
                 rs7756421 
                 A 
                 0.84 
                 10188 
                 2.16E−03 
                 1.19 
                 0.862 
                 1690 
                 4.45E−03 
                 1.16 
                 0.859 
                 2019 
               
               
                 C06 
                 29594220 
                 rs3094564 
                 G 
                 0.386 
                 10635 
                 2.17E−03 
                 1.13 
                 0.415 
                 1700 
                 4.26E−03 
                 1.11 
                 0.411 
                 2034 
               
               
                 C18 
                 53282820 
                 rs580647 
                 A 
                 0.886 
                 10622 
                 2.17E−03 
                 1.22 
                 0.904 
                 1698 
                 6.59E−03 
                 1.18 
                 0.901 
                 2031 
               
               
                 C14 
                 63874253 
                 rs7145500 
                 A 
                 0.661 
                 10634 
                 2.17E−03 
                 1.14 
                 0.69 
                 1700 
                 1.37E−03 
                 1.13 
                 0.689 
                 2034 
               
               
                 C02 
                 218495194 
                 rs1478581 
                 G 
                 0.819 
                 10632 
                 2.18E−03 
                 1.18 
                 0.841 
                 1700 
                 3.13E−03 
                 1.15 
                 0.839 
                 2032 
               
               
                 C13 
                 102932541 
                 rs1347329 
                 C 
                 0.592 
                 10616 
                 2.18E−03 
                 1.13 
                 0.621 
                 1700 
                 1.53E−02 
                 1.09 
                 0.614 
                 2033 
               
               
                 C05 
                 39159439 
                 rs444556 
                 C 
                 0.301 
                 10632 
                 2.18E−03 
                 1.14 
                 0.329 
                 1700 
                 3.08E−03 
                 1.12 
                 0.326 
                 2034 
               
               
                 C09 
                 14600866 
                 rs1343705 
                 G 
                 0.471 
                 10631 
                 2.18E−03 
                 1.13 
                 0.501 
                 1699 
                 3.38E−03 
                 1.11 
                 0.498 
                 2033 
               
               
                 C16 
                 19038467 
                 rs8053779 
                 G 
                 0.734 
                 10634 
                 2.19E−03 
                 1.15 
                 0.76 
                 1700 
                 1.04E−02 
                 1.11 
                 0.754 
                 2034 
               
               
                 C21 
                 26972748 
                 rs2830357 
                 G 
                 0.568 
                 10634 
                 2.19E−03 
                 1.13 
                 0.598 
                 1700 
                 1.78E−03 
                 1.12 
                 0.597 
                 2034 
               
               
                 C07 
                 77798006 
                 rs2192658 
                 T 
                 0.076 
                 10630 
                 2.19E−03 
                 1.24 
                 0.092 
                 1699 
                 1.17E−02 
                 1.18 
                 0.088 
                 2032 
               
               
                 C17 
                 62590633 
                 rs1985961 
                 C 
                 0.412 
                 10633 
                 2.20E−03 
                 1.13 
                 0.442 
                 1700 
                 2.23E−03 
                 1.12 
                 0.44 
                 2034 
               
               
                 C10 
                 96398926 
                 rs10509680 
                 T 
                 0.05 
                 10601 
                 2.20E−03 
                 1.29 
                 0.064 
                 1695 
                 9.38E−03 
                 1.23 
                 0.061 
                 2027 
               
               
                 C11 
                 98634196 
                 rs1461684 
                 T 
                 0.849 
                 10635 
                 2.20E−03 
                 1.19 
                 0.87 
                 1700 
                 8.48E−03 
                 1.15 
                 0.866 
                 2034 
               
               
                 C06 
                 106231995 
                 rs4440505 
                 C 
                 0.781 
                 10635 
                 2.20E−03 
                 1.16 
                 0.806 
                 1700 
                 5.16E−03 
                 1.13 
                 0.802 
                 2034 
               
               
                 C03 
                 14269176 
                 rs2128163 
                 G 
                 0.533 
                 10617 
                 2.21E−03 
                 1.13 
                 0.563 
                 1700 
                 2.43E−03 
                 1.12 
                 0.56 
                 2034 
               
               
                 C07 
                 8516487 
                 rs12234501 
                 T 
                 0.133 
                 10635 
                 2.22E−03 
                 1.19 
                 0.154 
                 1700 
                 6.54E−04 
                 1.19 
                 0.155 
                 2034 
               
               
                 C10 
                 84892441 
                 rs10886432 
                 G 
                 0.638 
                 10634 
                 2.22E−03 
                 1.14 
                 0.666 
                 1700 
                 1.76E−04 
                 1.16 
                 0.67 
                 2034 
               
               
                 C08 
                 41405289 
                 rs7819949 
                 T 
                 0.271 
                 10634 
                 2.23E−03 
                 1.14 
                 0.299 
                 1700 
                 4.46E−02 
                 1.08 
                 0.288 
                 2034 
               
               
                 C21 
                 42743171 
                 rs3788014 
                 C 
                 0.925 
                 10631 
                 2.23E−03 
                 1.28 
                 0.94 
                 1700 
                 2.98E−03 
                 1.24 
                 0.939 
                 2033 
               
               
                 C16 
                 75032079 
                 rs4243110 
                 T 
                 0.458 
                 10628 
                 2.23E−03 
                 1.13 
                 0.489 
                 1699 
                 4.24E−03 
                 1.11 
                 0.485 
                 2033 
               
               
                 C15 
                 52604593 
                 rs2414325 
                 T 
                 0.489 
                 10634 
                 2.23E−03 
                 1.13 
                 0.519 
                 1700 
                 1.35E−03 
                 1.12 
                 0.518 
                 2034 
               
               
                 C07 
                 86657613 
                 rs31662 
                 G 
                 0.862 
                 10635 
                 2.24E−03 
                 1.2 
                 0.882 
                 1700 
                 4.06E−03 
                 1.17 
                 0.88 
                 2034 
               
               
                 C01 
                 148824678 
                 rs6702842 
                 G 
                 0.269 
                 10611 
                 2.25E−03 
                 1.14 
                 0.296 
                 1694 
                 1.24E−02 
                 1.11 
                 0.289 
                 2028 
               
               
                 C06 
                 28141066 
                 rs149951 
                 T 
                 0.726 
                 10635 
                 2.25E−03 
                 1.15 
                 0.753 
                 1700 
                 2.41E−02 
                 1.1 
                 0.744 
                 2034 
               
               
                 C06 
                 28335583 
                 rs1635 
                 G 
                 0.942 
                 10565 
                 2.25E−03 
                 1.32 
                 0.955 
                 1689 
                 8.32E−03 
                 1.24 
                 0.953 
                 2019 
               
               
                 C16 
                 53594877 
                 rs8050136 
                 A 
                 0.404 
                 10634 
                 2.26E−03 
                 1.13 
                 0.433 
                 1699 
                 4.22E−04 
                 1.14 
                 0.436 
                 2033 
               
               
                 C19 
                 48943265 
                 rs346535 
                 T 
                 0.234 
                 10635 
                 2.26E−03 
                 1.15 
                 0.26 
                 1700 
                 4.17E−03 
                 1.13 
                 0.257 
                 2034 
               
               
                 C13 
                 101270990 
                 rs2038709 
                 C 
                 0.081 
                 10629 
                 2.26E−03 
                 1.23 
                 0.098 
                 1700 
                 1.17E−02 
                 1.18 
                 0.094 
                 2034 
               
               
                 C01 
                 19425721 
                 rs3748744 
                 G 
                 0.899 
                 10634 
                 2.26E−03 
                 1.23 
                 0.916 
                 1700 
                 2.68E−02 
                 1.15 
                 0.911 
                 2034 
               
               
                 C04 
                 107037574 
                 rs1982346 
                 C 
                 0.062 
                 10480 
                 2.27E−03 
                 1.27 
                 0.077 
                 1682 
                 1.13E−03 
                 1.26 
                 0.077 
                 2011 
               
               
                 C15 
                 34830800 
                 rs1194620 
                 T 
                 0.232 
                 10633 
                 2.27E−03 
                 1.15 
                 0.257 
                 1700 
                 9.03E−03 
                 1.12 
                 0.252 
                 2034 
               
               
                 C10 
                 5948421 
                 rs7912210 
                 C 
                 0.963 
                 10616 
                 2.28E−03 
                 1.42 
                 0.973 
                 1679 
                 5.95E−04 
                 1.45 
                 0.974 
                 2012 
               
               
                 C21 
                 14334270 
                 rs2822391 
                 A 
                 0.548 
                 10634 
                 2.28E−03 
                 1.13 
                 0.578 
                 1700 
                 8.05E−04 
                 1.13 
                 0.578 
                 2034 
               
               
                 C05 
                 15952862 
                 rs7715223 
                 C 
                 0.819 
                 10597 
                 2.28E−03 
                 1.18 
                 0.842 
                 1692 
                 1.73E−02 
                 1.12 
                 0.835 
                 2026 
               
               
                 C02 
                 75385815 
                 rs4853116 
                 A 
                 0.624 
                 10364 
                 2.29E−03 
                 1.13 
                 0.653 
                 1695 
                 2.15E−03 
                 1.12 
                 0.651 
                 2025 
               
               
                 C05 
                 56050092 
                 rs4700485 
                 A 
                 0.322 
                 10635 
                 2.29E−03 
                 1.14 
                 0.351 
                 1700 
                 1.00E−02 
                 1.1 
                 0.344 
                 2034 
               
               
                 C01 
                 184820295 
                 rs2383658 
                 G 
                 0.388 
                 10633 
                 2.29E−03 
                 1.13 
                 0.417 
                 1700 
                 1.58E−03 
                 1.12 
                 0.416 
                 2034 
               
               
                 C03 
                 82844262 
                 rs13075335 
                 T 
                 0.9 
                 10058 
                 2.29E−03 
                 1.24 
                 0.918 
                 1678 
                 9.58E−03 
                 1.18 
                 0.914 
                 2004 
               
               
                 C04 
                 82322766 
                 rs6830629 
                 A 
                 0.975 
                 10625 
                 2.30E−03 
                 1.56 
                 0.984 
                 1699 
                 8.03E−03 
                 1.41 
                 0.983 
                 2032 
               
               
                 C14 
                 63868436 
                 rs2411822 
                 C 
                 0.485 
                 10630 
                 2.30E−03 
                 1.13 
                 0.515 
                 1700 
                 9.77E−03 
                 1.1 
                 0.509 
                 2034 
               
               
                 C05 
                 55844670 
                 rs30365 
                 C 
                 0.898 
                 10635 
                 2.30E−03 
                 1.23 
                 0.915 
                 1700 
                 5.89E−03 
                 1.19 
                 0.912 
                 2034 
               
               
                 C06 
                 29516393 
                 rs2074464 
                 T 
                 0.445 
                 10625 
                 2.31E−03 
                 1.13 
                 0.475 
                 1699 
                 9.91E−03 
                 1.1 
                 0.469 
                 2033 
               
               
                 C06 
                 29588861 
                 rs3094572 
                 A 
                 0.386 
                 10635 
                 2.31E−03 
                 1.13 
                 0.416 
                 1700 
                 4.61E−03 
                 1.11 
                 0.412 
                 2034 
               
               
                 C01 
                 218026319 
                 rs2642438 
                 G 
                 0.71 
                 10581 
                 2.31E−03 
                 1.14 
                 0.737 
                 1693 
                 1.21E−02 
                 1.11 
                 0.731 
                 2025 
               
               
                 C14 
                 101389489 
                 rs4708 
                 A 
                 0.546 
                 10627 
                 2.31E−03 
                 1.13 
                 0.576 
                 1698 
                 4.92E−03 
                 1.11 
                 0.572 
                 2030 
               
               
                 C02 
                 76278450 
                 rs404892 
                 C 
                 0.505 
                 10634 
                 2.31E−03 
                 1.13 
                 0.535 
                 1700 
                 3.19E−03 
                 1.11 
                 0.532 
                 2034 
               
               
                 C11 
                 1341537 
                 rs7122936 
                 A 
                 0.572 
                 10556 
                 2.31E−03 
                 1.13 
                 0.602 
                 1700 
                 4.84E−03 
                 1.11 
                 0.598 
                 2034 
               
               
                 C11 
                 1341537 
                 rs7122936 
                 A 
                 0.572 
                 10556 
                 2.31E−03 
                 1.13 
                 0.602 
                 1700 
                 4.84E−03 
                 1.11 
                 0.598 
                 2034 
               
               
                 C05 
                 56080018 
                 rs12657615 
                 C 
                 0.115 
                 10635 
                 2.32E−03 
                 1.2 
                 0.135 
                 1700 
                 5.17E−03 
                 1.17 
                 0.132 
                 2034 
               
               
                 C14 
                 64537666 
                 rs6573648 
                 G 
                 0.274 
                 10634 
                 2.33E−03 
                 1.14 
                 0.301 
                 1700 
                 2.25E−03 
                 1.13 
                 0.299 
                 2034 
               
               
                 C17 
                 70794100 
                 rs2159010 
                 A 
                 0.727 
                 10583 
                 2.33E−03 
                 1.15 
                 0.753 
                 1700 
                 4.40E−03 
                 1.13 
                 0.75 
                 2032 
               
               
                 C07 
                 46518795 
                 rs956010 
                 A 
                 0.88 
                 10635 
                 2.33E−03 
                 1.21 
                 0.899 
                 1700 
                 2.09E−03 
                 1.2 
                 0.898 
                 2034 
               
               
                 C15 
                 92040939 
                 rs10152962 
                 G 
                 0.154 
                 10635 
                 2.33E−03 
                 1.17 
                 0.176 
                 1700 
                 7.80E−04 
                 1.18 
                 0.177 
                 2034 
               
               
                 C20 
                 49591938 
                 rs913670 
                 C 
                 0.631 
                 10595 
                 2.33E−03 
                 1.13 
                 0.66 
                 1700 
                 3.99E−03 
                 1.12 
                 0.656 
                 2033 
               
               
                 C20 
                 57938553 
                 rs6128397 
                 G 
                 0.689 
                 10633 
                 2.34E−03 
                 1.14 
                 0.716 
                 1700 
                 7.46E−03 
                 1.11 
                 0.711 
                 2034 
               
               
                 C21 
                 21803122 
                 rs2017705 
                 C 
                 0.073 
                 10598 
                 2.34E−03 
                 1.24 
                 0.089 
                 1696 
                 1.14E−02 
                 1.19 
                 0.086 
                 2029 
               
               
                 C05 
                 3996863 
                 rs634344 
                 G 
                 0.067 
                 10633 
                 2.34E−03 
                 1.25 
                 0.082 
                 1700 
                 6.05E−03 
                 1.21 
                 0.079 
                 2033 
               
               
                 C06 
                 27418512 
                 rs9461366 
                 G 
                 0.614 
                 10635 
                 2.34E−03 
                 1.13 
                 0.643 
                 1700 
                 6.05E−03 
                 1.11 
                 0.638 
                 2034 
               
               
                 C22 
                 19648862 
                 rs178260 
                 T 
                 0.14 
                 10632 
                 2.34E−03 
                 1.18 
                 0.161 
                 1700 
                 6.21E−03 
                 1.15 
                 0.158 
                 2034 
               
               
                 C09 
                 112545345 
                 rs2236388 
                 G 
                 0.899 
                 10634 
                 2.35E−03 
                 1.23 
                 0.917 
                 1700 
                 7.73E−04 
                 1.24 
                 0.917 
                 2034 
               
               
                 C07 
                 19730452 
                 rs10486378 
                 G 
                 0.277 
                 10449 
                 2.35E−03 
                 1.14 
                 0.304 
                 1673 
                 1.11E−02 
                 1.11 
                 0.298 
                 2002 
               
               
                 C05 
                 6325742 
                 rs1457122 
                 T 
                 0.333 
                 10633 
                 2.35E−03 
                 1.13 
                 0.361 
                 1700 
                 2.33E−03 
                 1.12 
                 0.359 
                 2034 
               
               
                 C08 
                 92473760 
                 rs2607102 
                 T 
                 0.927 
                 10586 
                 2.35E−03 
                 1.28 
                 0.942 
                 1690 
                 5.93E−03 
                 1.23 
                 0.939 
                 2020 
               
               
                 C06 
                 165937562 
                 rs9348022 
                 T 
                 0.657 
                 10631 
                 2.37E−03 
                 1.14 
                 0.685 
                 1699 
                 5.08E−03 
                 1.12 
                 0.681 
                 2033 
               
               
                 C10 
                 78039047 
                 rs1865017 
                 C 
                 0.734 
                 10633 
                 2.37E−03 
                 1.15 
                 0.76 
                 1700 
                 5.34E−03 
                 1.12 
                 0.756 
                 2034 
               
               
                 C13 
                 45593565 
                 rs9534568 
                 A 
                 0.76 
                 10269 
                 2.37E−03 
                 1.15 
                 0.785 
                 1695 
                 2.46E−03 
                 1.14 
                 0.783 
                 2024 
               
               
                 C08 
                 32774151 
                 rs9656744 
                 T 
                 0.511 
                 10632 
                 2.38E−03 
                 1.13 
                 0.541 
                 1699 
                 3.71E−03 
                 1.11 
                 0.537 
                 2030 
               
               
                 C09 
                 68331465 
                 rs943535 
                 A 
                 0.917 
                 10584 
                 2.39E−03 
                 1.26 
                 0.933 
                 1690 
                 9.80E−04 
                 1.26 
                 0.933 
                 2020 
               
               
                 C10 
                 87769103 
                 rs10749535 
                 T 
                 0.472 
                 10635 
                 2.40E−03 
                 1.13 
                 0.502 
                 1700 
                 2.92E−03 
                 1.11 
                 0.499 
                 2034 
               
               
                 C11 
                 98579265 
                 rs7120353 
                 T 
                 0.899 
                 10634 
                 2.40E−03 
                 1.23 
                 0.916 
                 1700 
                 2.08E−03 
                 1.22 
                 0.915 
                 2034 
               
               
                 C05 
                 31377276 
                 rs6875512 
                 A 
                 0.742 
                 10632 
                 2.40E−03 
                 1.15 
                 0.768 
                 1700 
                 7.97E−03 
                 1.12 
                 0.763 
                 2034 
               
               
                 C02 
                 198322740 
                 rs6434921 
                 A 
                 0.392 
                 10635 
                 2.40E−03 
                 1.13 
                 0.421 
                 1700 
                 1.59E−02 
                 1.09 
                 0.414 
                 2034 
               
               
                 C06 
                 5382731 
                 rs2113691 
                 C 
                 0.488 
                 10479 
                 2.40E−03 
                 1.13 
                 0.518 
                 1644 
                 3.11E−03 
                 1.12 
                 0.515 
                 1974 
               
               
                 C10 
                 50087691 
                 rs3793786 
                 C 
                 0.24 
                 10635 
                 2.40E−03 
                 1.15 
                 0.266 
                 1700 
                 4.64E−03 
                 1.13 
                 0.262 
                 2034 
               
               
                 C08 
                 23073423 
                 rs11775256 
                 T 
                 0.27 
                 10634 
                 2.41E−03 
                 1.14 
                 0.297 
                 1700 
                 9.12E−03 
                 1.11 
                 0.292 
                 2034 
               
               
                 C12 
                 116686949 
                 rs2592289 
                 A 
                 0.156 
                 10632 
                 2.41E−03 
                 1.17 
                 0.179 
                 1700 
                 2.57E−03 
                 1.16 
                 0.177 
                 2034 
               
               
                 C07 
                 157067324 
                 rs11769878 
                 C 
                 0.742 
                 10433 
                 2.41E−03 
                 1.15 
                 0.768 
                 1690 
                 2.84E−03 
                 1.14 
                 0.766 
                 2022 
               
               
                 C11 
                 56669965 
                 rs717117 
                 G 
                 0.075 
                 10632 
                 2.41E−03 
                 1.24 
                 0.091 
                 1700 
                 7.09E−03 
                 1.19 
                 0.088 
                 2034 
               
               
                 C21 
                 14824849 
                 rs2822753 
                 G 
                 0.357 
                 10631 
                 2.41E−03 
                 1.13 
                 0.386 
                 1700 
                 4.57E−03 
                 1.11 
                 0.382 
                 2034 
               
               
                 C16 
                 53995959 
                 rs1033043 
                 T 
                 0.574 
                 10635 
                 2.41E−03 
                 1.13 
                 0.604 
                 1700 
                 1.67E−02 
                 1.09 
                 0.596 
                 2034 
               
               
                 C09 
                 33091838 
                 rs10758186 
                 G 
                 0.381 
                 10633 
                 2.41E−03 
                 1.13 
                 0.41 
                 1700 
                 5.48E−03 
                 1.11 
                 0.406 
                 2034 
               
               
                 C08 
                 125394399 
                 rs4620270 
                 T 
                 0.13 
                 10627 
                 2.42E−03 
                 1.19 
                 0.15 
                 1699 
                 8.40E−04 
                 1.19 
                 0.151 
                 2033 
               
               
                 C01 
                 69518464 
                 rs10489554 
                 T 
                 0.77 
                 10633 
                 2.42E−03 
                 1.16 
                 0.795 
                 1700 
                 4.45E−03 
                 1.13 
                 0.792 
                 2034 
               
               
                 C01 
                 153811448 
                 rs12567958 
                 C 
                 0.266 
                 10615 
                 2.42E−03 
                 1.14 
                 0.293 
                 1700 
                 7.12E−03 
                 1.12 
                 0.288 
                 2034 
               
               
                 C04 
                 17086471 
                 rs7442366 
                 T 
                 0.821 
                 10635 
                 2.42E−03 
                 1.17 
                 0.844 
                 1700 
                 4.54E−04 
                 1.19 
                 0.845 
                 2034 
               
               
                 C07 
                 99312573 
                 rs999885 
                 T 
                 0.498 
                 10467 
                 2.43E−03 
                 1.13 
                 0.528 
                 1678 
                 4.30E−03 
                 1.11 
                 0.524 
                 2012 
               
               
                 C03 
                 61747598 
                 rs603052 
                 T 
                 0.778 
                 10629 
                 2.43E−03 
                 1.16 
                 0.802 
                 1700 
                 4.06E−03 
                 1.14 
                 0.799 
                 2034 
               
               
                 C07 
                 72804700 
                 rs7787362 
                 C 
                 0.557 
                 10628 
                 2.43E−03 
                 1.13 
                 0.587 
                 1700 
                 1.23E−02 
                 1.1 
                 0.58 
                 2034 
               
               
                 C06 
                 79723924 
                 rs1338023 
                 T 
                 0.623 
                 10465 
                 2.43E−03 
                 1.13 
                 0.652 
                 1647 
                 3.54E−03 
                 1.12 
                 0.649 
                 1975 
               
               
                 C05 
                 667701 
                 rs1697952 
                 C 
                 0.368 
                 10612 
                 2.43E−03 
                 1.13 
                 0.397 
                 1697 
                 4.73E−03 
                 1.11 
                 0.393 
                 2030 
               
               
                 C17 
                 40648038 
                 rs1122326 
                 C 
                 0.241 
                 10633 
                 2.44E−03 
                 1.15 
                 0.267 
                 1700 
                 3.93E−03 
                 1.13 
                 0.264 
                 2034 
               
               
                 C10 
                 10412081 
                 rs10508403 
                 T 
                 0.091 
                 10635 
                 2.44E−03 
                 1.22 
                 0.109 
                 1700 
                 2.93E−02 
                 1.14 
                 0.103 
                 2034 
               
               
                 C02 
                 171512196 
                 rs1837241 
                 A 
                 0.697 
                 10634 
                 2.44E−03 
                 1.14 
                 0.724 
                 1700 
                 1.28E−03 
                 1.14 
                 0.724 
                 2034 
               
               
                 C06 
                 17345030 
                 rs6940891 
                 C 
                 0.169 
                 10635 
                 2.45E−03 
                 1.17 
                 0.192 
                 1700 
                 2.87E−03 
                 1.15 
                 0.19 
                 2034 
               
               
                 C06 
                 42287224 
                 rs713383 
                 G 
                 0.684 
                 10635 
                 2.45E−03 
                 1.14 
                 0.712 
                 1700 
                 4.07E−03 
                 1.12 
                 0.708 
                 2034 
               
               
                 C12 
                 121500993 
                 rs7979863 
                 A 
                 0.375 
                 10630 
                 2.46E−03 
                 1.13 
                 0.404 
                 1700 
                 2.05E−03 
                 1.12 
                 0.402 
                 2034 
               
               
                 C06 
                 37577310 
                 rs9380681 
                 C 
                 0.308 
                 10635 
                 2.46E−03 
                 1.14 
                 0.335 
                 1700 
                 2.37E−03 
                 1.13 
                 0.333 
                 2034 
               
               
                 C17 
                 77817713 
                 rs17674253 
                 A 
                 0.579 
                 10632 
                 2.46E−03 
                 1.13 
                 0.608 
                 1698 
                 7.85E−03 
                 1.1 
                 0.603 
                 2032 
               
               
                 C01 
                 113140463 
                 rs773586 
                 A 
                 0.483 
                 10633 
                 2.46E−03 
                 1.13 
                 0.513 
                 1700 
                 3.45E−04 
                 1.14 
                 0.515 
                 2034 
               
               
                 C06 
                 92200200 
                 rs6454860 
                 G 
                 0.325 
                 10314 
                 2.46E−03 
                 1.14 
                 0.353 
                 1639 
                 3.16E−03 
                 1.12 
                 0.35 
                 1969 
               
               
                 C10 
                 61460650 
                 rs4948410 
                 A 
                 0.784 
                 10631 
                 2.47E−03 
                 1.16 
                 0.808 
                 1700 
                 4.52E−03 
                 1.14 
                 0.805 
                 2034 
               
               
                 C06 
                 157865565 
                 rs16900254 
                 A 
                 0.408 
                 10635 
                 2.47E−03 
                 1.13 
                 0.437 
                 1700 
                 1.34E−02 
                 1.1 
                 0.43 
                 2034 
               
               
                 C15 
                 93466050 
                 rs176656 
                 A 
                 0.09 
                 10635 
                 2.48E−03 
                 1.22 
                 0.108 
                 1700 
                 6.94E−04 
                 1.23 
                 0.109 
                 2034 
               
               
                 C11 
                 102978426 
                 rs719527 
                 C 
                 0.233 
                 10612 
                 2.49E−03 
                 1.15 
                 0.258 
                 1700 
                 5.40E−03 
                 1.13 
                 0.254 
                 2034 
               
               
                 C20 
                 57627978 
                 rs6128327 
                 A 
                 0.64 
                 10481 
                 2.50E−03 
                 1.13 
                 0.668 
                 1683 
                 1.61E−03 
                 1.13 
                 0.667 
                 2015 
               
               
                 C07 
                 21751434 
                 rs1174943 
                 G 
                 0.155 
                 10631 
                 2.51E−03 
                 1.17 
                 0.176 
                 1700 
                 1.20E−02 
                 1.13 
                 0.171 
                 2034 
               
               
                 C07 
                 8617064 
                 rs917038 
                 C 
                 0.784 
                 10591 
                 2.51E−03 
                 1.16 
                 0.808 
                 1689 
                 2.80E−02 
                 1.1 
                 0.8 
                 2023 
               
               
                 C20 
                 22311552 
                 rs199812 
                 C 
                 0.886 
                 10635 
                 2.51E−03 
                 1.22 
                 0.904 
                 1700 
                 9.30E−04 
                 1.22 
                 0.904 
                 2034 
               
               
                 C04 
                 147576738 
                 rs2241521 
                 A 
                 0.234 
                 10634 
                 2.51E−03 
                 1.15 
                 0.26 
                 1700 
                 1.05E−02 
                 1.11 
                 0.254 
                 2034 
               
               
                 C11 
                 20014361 
                 rs920671 
                 A 
                 0.182 
                 10634 
                 2.51E−03 
                 1.16 
                 0.205 
                 1700 
                 2.83E−03 
                 1.15 
                 0.203 
                 2034 
               
               
                 C11 
                 82788837 
                 rs4623925 
                 A 
                 0.267 
                 10633 
                 2.51E−03 
                 1.14 
                 0.294 
                 1700 
                 2.34E−02 
                 1.1 
                 0.286 
                 2034 
               
               
                 C21 
                 24056599 
                 rs2828515 
                 G 
                 0.122 
                 10633 
                 2.52E−03 
                 1.19 
                 0.142 
                 1700 
                 8.56E−04 
                 1.2 
                 0.143 
                 2034 
               
               
                 C02 
                 44054859 
                 rs6709904 
                 A 
                 0.907 
                 10635 
                 2.52E−03 
                 1.24 
                 0.924 
                 1700 
                 1.38E−03 
                 1.24 
                 0.924 
                 2034 
               
               
                 C17 
                 21252111 
                 rs9911448 
                 C 
                 0.962 
                 10635 
                 2.52E−03 
                 1.41 
                 0.972 
                 1700 
                 5.90E−03 
                 1.33 
                 0.971 
                 2034 
               
               
                 C18 
                 55909735 
                 rs9948303 
                 G 
                 0.099 
                 10635 
                 2.52E−03 
                 1.21 
                 0.117 
                 1700 
                 1.15E−03 
                 1.21 
                 0.117 
                 2034 
               
               
                 C01 
                 20385176 
                 rs2072671 
                 C 
                 0.314 
                 10635 
                 2.53E−03 
                 1.13 
                 0.341 
                 1700 
                 8.33E−04 
                 1.14 
                 0.342 
                 2034 
               
               
                 C01 
                 113074488 
                 rs6688859 
                 T 
                 0.68 
                 10635 
                 2.53E−03 
                 1.14 
                 0.708 
                 1700 
                 2.92E−04 
                 1.15 
                 0.711 
                 2034 
               
               
                 C15 
                 95693327 
                 rs7177625 
                 G 
                 0.683 
                 10633 
                 2.53E−03 
                 1.14 
                 0.71 
                 1700 
                 9.07E−03 
                 1.11 
                 0.705 
                 2033 
               
               
                 C12 
                 20118148 
                 rs11045018 
                 G 
                 0.749 
                 10626 
                 2.53E−03 
                 1.15 
                 0.774 
                 1699 
                 5.07E−04 
                 1.16 
                 0.776 
                 2033 
               
               
                 C16 
                 82538999 
                 rs1870843 
                 T 
                 0.599 
                 10633 
                 2.53E−03 
                 1.13 
                 0.628 
                 1700 
                 2.99E−03 
                 1.12 
                 0.625 
                 2034 
               
               
                 C01 
                 78369472 
                 rs1543675 
                 C 
                 0.376 
                 10633 
                 2.53E−03 
                 1.13 
                 0.405 
                 1700 
                 1.08E−02 
                 1.1 
                 0.399 
                 2034 
               
               
                 C01 
                 107498557 
                 rs2335793 
                 C 
                 0.887 
                 10628 
                 2.53E−03 
                 1.22 
                 0.905 
                 1698 
                 8.13E−04 
                 1.23 
                 0.906 
                 2031 
               
               
                 C03 
                 6741178 
                 rs978658 
                 G 
                 0.611 
                 10635 
                 2.54E−03 
                 1.13 
                 0.639 
                 1700 
                 1.13E−03 
                 1.13 
                 0.639 
                 2034 
               
               
                 C05 
                 76843306 
                 rs690280 
                 T 
                 0.422 
                 10580 
                 2.54E−03 
                 1.13 
                 0.451 
                 1694 
                 8.75E−03 
                 1.1 
                 0.446 
                 2028 
               
               
                 C10 
                 30821283 
                 rs7086224 
                 A 
                 0.418 
                 10633 
                 2.54E−03 
                 1.13 
                 0.448 
                 1700 
                 4.77E−03 
                 1.11 
                 0.444 
                 2034 
               
               
                 C07 
                 86648971 
                 rs2373593 
                 A 
                 0.862 
                 10635 
                 2.55E−03 
                 1.2 
                 0.882 
                 1700 
                 4.51E−03 
                 1.17 
                 0.88 
                 2034 
               
               
                 C19 
                 53768499 
                 rs3760802 
                 A 
                 0.499 
                 10633 
                 2.55E−03 
                 1.13 
                 0.528 
                 1699 
                 3.62E−03 
                 1.11 
                 0.525 
                 2033 
               
               
                 C17 
                 40663717 
                 rs12603327 
                 C 
                 0.241 
                 10632 
                 2.55E−03 
                 1.15 
                 0.267 
                 1700 
                 4.05E−03 
                 1.13 
                 0.264 
                 2034 
               
               
                 C10 
                 101886011 
                 rs1539089 
                 C 
                 0.222 
                 10635 
                 2.55E−03 
                 1.15 
                 0.247 
                 1700 
                 1.13E−02 
                 1.12 
                 0.241 
                 2034 
               
               
                 C19 
                 8795907 
                 rs10406508 
                 T 
                 0.764 
                 10635 
                 2.56E−03 
                 1.15 
                 0.789 
                 1700 
                 2.84E−02 
                 1.1 
                 0.78 
                 2034 
               
               
                 C05 
                 50786999 
                 rs1423611 
                 C 
                 0.445 
                 10631 
                 2.56E−03 
                 1.13 
                 0.474 
                 1700 
                 5.58E−03 
                 1.11 
                 0.47 
                 2034 
               
               
                 C05 
                 50786999 
                 rs1423611 
                 C 
                 0.445 
                 10631 
                 2.56E−03 
                 1.13 
                 0.474 
                 1700 
                 5.58E−03 
                 1.11 
                 0.47 
                 2034 
               
               
                 C06 
                 29574824 
                 rs1345227 
                 G 
                 0.379 
                 10630 
                 2.57E−03 
                 1.13 
                 0.408 
                 1700 
                 4.62E−03 
                 1.11 
                 0.404 
                 2034 
               
               
                 C02 
                 172857641 
                 rs6758704 
                 T 
                 0.709 
                 10633 
                 2.57E−03 
                 1.14 
                 0.736 
                 1700 
                 4.05E−03 
                 1.12 
                 0.733 
                 2034 
               
               
                 C05 
                 9699750 
                 rs2106687 
                 G 
                 0.125 
                 10631 
                 2.58E−03 
                 1.19 
                 0.146 
                 1700 
                 6.01E−03 
                 1.16 
                 0.142 
                 2033 
               
               
                 C22 
                 19683076 
                 rs430305 
                 T 
                 0.828 
                 10635 
                 2.58E−03 
                 1.18 
                 0.85 
                 1700 
                 2.96E−03 
                 1.16 
                 0.848 
                 2034 
               
               
                 C19 
                 22695812 
                 rs4933027 
                 T 
                 0.085 
                 10634 
                 2.58E−03 
                 1.22 
                 0.102 
                 1700 
                 9.19E−03 
                 1.18 
                 0.099 
                 2034 
               
               
                 C11 
                 83108627 
                 rs7952084 
                 A 
                 0.357 
                 10635 
                 2.58E−03 
                 1.13 
                 0.386 
                 1700 
                 5.81E−03 
                 1.11 
                 0.382 
                 2034 
               
               
                 C07 
                 27992355 
                 rs10225945 
                 A 
                 0.846 
                 10535 
                 2.59E−03 
                 1.19 
                 0.867 
                 1697 
                 4.58E−03 
                 1.16 
                 0.865 
                 2030 
               
               
                 C04 
                 10063925 
                 rs714086 
                 G 
                 0.759 
                 10631 
                 2.59E−03 
                 1.15 
                 0.784 
                 1700 
                 1.36E−02 
                 1.11 
                 0.778 
                 2033 
               
               
                 C08 
                 138245904 
                 rs4451334 
                 A 
                 0.062 
                 10632 
                 2.59E−03 
                 1.26 
                 0.077 
                 1698 
                 7.62E−03 
                 1.21 
                 0.074 
                 2032 
               
               
                 C05 
                 115396824 
                 rs9326981 
                 C 
                 0.949 
                 10634 
                 2.59E−03 
                 1.34 
                 0.961 
                 1700 
                 3.01E−03 
                 1.3 
                 0.96 
                 2034 
               
               
                 C10 
                 101903540 
                 rs11190578 
                 T 
                 0.222 
                 10631 
                 2.59E−03 
                 1.15 
                 0.247 
                 1700 
                 1.15E−02 
                 1.12 
                 0.241 
                 2034 
               
               
                 C10 
                 102146771 
                 rs4630219 
                 C 
                 0.099 
                 10572 
                 2.60E−03 
                 1.21 
                 0.117 
                 1696 
                 2.90E−03 
                 1.19 
                 0.115 
                 2027 
               
               
                 C17 
                 40667190 
                 rs7214921 
                 C 
                 0.241 
                 10634 
                 2.60E−03 
                 1.15 
                 0.267 
                 1700 
                 4.13E−03 
                 1.13 
                 0.264 
                 2034 
               
               
                 C14 
                 64300426 
                 rs12433694 
                 C 
                 0.479 
                 10635 
                 2.61E−03 
                 1.13 
                 0.509 
                 1700 
                 1.43E−02 
                 1.09 
                 0.501 
                 2034 
               
               
                 C22 
                 18282773 
                 rs1978058 
                 T 
                 0.376 
                 10630 
                 2.61E−03 
                 1.13 
                 0.404 
                 1700 
                 1.08E−02 
                 1.1 
                 0.398 
                 2033 
               
               
                 C04 
                 131671262 
                 rs1027884 
                 T 
                 0.497 
                 10634 
                 2.61E−03 
                 1.13 
                 0.527 
                 1700 
                 2.40E−03 
                 1.12 
                 0.525 
                 2034 
               
               
                 C08 
                 28224848 
                 rs904053 
                 G 
                 0.225 
                 10634 
                 2.61E−03 
                 1.15 
                 0.25 
                 1700 
                 3.98E−02 
                 1.09 
                 0.24 
                 2034 
               
               
                 C08 
                 28224848 
                 rs904053 
                 G 
                 0.225 
                 10634 
                 2.61E−03 
                 1.15 
                 0.25 
                 1700 
                 3.98E−02 
                 1.09 
                 0.24 
                 2034 
               
               
                 C16 
                 54000987 
                 rs2665282 
                 A 
                 0.574 
                 10607 
                 2.61E−03 
                 1.13 
                 0.603 
                 1696 
                 1.79E−02 
                 1.09 
                 0.596 
                 2030 
               
               
                 C05 
                 136028429 
                 rs4141140 
                 G 
                 0.7 
                 10632 
                 2.62E−03 
                 1.14 
                 0.727 
                 1700 
                 1.58E−02 
                 1.1 
                 0.721 
                 2034 
               
               
                 C07 
                 49507399 
                 rs13240380 
                 T 
                 0.434 
                 10632 
                 2.62E−03 
                 1.13 
                 0.463 
                 1700 
                 1.78E−03 
                 1.12 
                 0.462 
                 2033 
               
               
                 C09 
                 11743695 
                 rs10960174 
                 G 
                 0.613 
                 10629 
                 2.62E−03 
                 1.13 
                 0.641 
                 1698 
                 1.74E−03 
                 1.13 
                 0.64 
                 2031 
               
               
                 C15 
                 43706836 
                 rs7172161 
                 G 
                 0.513 
                 10634 
                 2.62E−03 
                 1.13 
                 0.543 
                 1700 
                 2.59E−03 
                 1.12 
                 0.541 
                 2034 
               
               
                 C04 
                 162740637 
                 rs9942159 
                 T 
                 0.377 
                 10550 
                 2.63E−03 
                 1.13 
                 0.406 
                 1691 
                 2.09E−03 
                 1.12 
                 0.404 
                 2024 
               
               
                 C05 
                 158736740 
                 rs1433048 
                 G 
                 0.192 
                 10317 
                 2.63E−03 
                 1.16 
                 0.216 
                 1652 
                 1.82E−02 
                 1.11 
                 0.21 
                 1981 
               
               
                 C10 
                 84886235 
                 rs4411234 
                 C 
                 0.638 
                 10631 
                 2.63E−03 
                 1.13 
                 0.666 
                 1700 
                 2.14E−04 
                 1.15 
                 0.67 
                 2034 
               
               
                 C12 
                 100468481 
                 rs864302 
                 T 
                 0.483 
                 10630 
                 2.63E−03 
                 1.13 
                 0.512 
                 1700 
                 7.50E−03 
                 1.1 
                 0.507 
                 2034 
               
               
                 C05 
                 76657043 
                 rs251421 
                 C 
                 0.26 
                 10618 
                 2.64E−03 
                 1.14 
                 0.286 
                 1690 
                 5.58E−03 
                 1.12 
                 0.283 
                 2023 
               
               
                 C07 
                 46531242 
                 rs6956126 
                 G 
                 0.885 
                 10632 
                 2.64E−03 
                 1.22 
                 0.904 
                 1700 
                 2.41E−03 
                 1.2 
                 0.903 
                 2034 
               
               
                 C09 
                 129104520 
                 rs7026302 
                 G 
                 0.908 
                 10633 
                 2.64E−03 
                 1.24 
                 0.924 
                 1700 
                 2.87E−02 
                 1.15 
                 0.919 
                 2034 
               
               
                 C11 
                 121657794 
                 rs531743 
                 A 
                 0.954 
                 10633 
                 2.64E−03 
                 1.36 
                 0.966 
                 1700 
                 2.00E−03 
                 1.34 
                 0.965 
                 2034 
               
               
                 C11 
                 33462777 
                 rs10836066 
                 T 
                 0.301 
                 10634 
                 2.65E−03 
                 1.14 
                 0.328 
                 1700 
                 3.03E−02 
                 1.09 
                 0.319 
                 2034 
               
               
                 C05 
                 122595829 
                 rs9327287 
                 G 
                 0.262 
                 10632 
                 2.65E−03 
                 1.14 
                 0.288 
                 1700 
                 7.19E−03 
                 1.12 
                 0.284 
                 2034 
               
               
                 C04 
                 181363537 
                 rs17090640 
                 G 
                 0.952 
                 10635 
                 2.65E−03 
                 1.35 
                 0.964 
                 1700 
                 1.64E−02 
                 1.24 
                 0.961 
                 2034 
               
               
                 C04 
                 119551429 
                 rs6820367 
                 A 
                 0.35 
                 10634 
                 2.65E−03 
                 1.13 
                 0.379 
                 1700 
                 4.66E−03 
                 1.11 
                 0.375 
                 2034 
               
               
                 C19 
                 62070079 
                 rs8113561 
                 G 
                 0.954 
                 10625 
                 2.65E−03 
                 1.36 
                 0.966 
                 1700 
                 3.66E−02 
                 1.21 
                 0.962 
                 2034 
               
               
                 C08 
                 97162902 
                 rs2440213 
                 A 
                 0.358 
                 10632 
                 2.65E−03 
                 1.13 
                 0.387 
                 1700 
                 5.98E−03 
                 1.11 
                 0.383 
                 2033 
               
               
                 C10 
                 93013669 
                 rs1028935 
                 A 
                 0.185 
                 10633 
                 2.65E−03 
                 1.16 
                 0.208 
                 1700 
                 1.86E−03 
                 1.15 
                 0.207 
                 2034 
               
               
                 C06 
                 24562175 
                 rs9393558 
                 T 
                 0.347 
                 10635 
                 2.65E−03 
                 1.13 
                 0.375 
                 1700 
                 2.11E−02 
                 1.09 
                 0.367 
                 2034 
               
               
                 C09 
                 103242888 
                 rs7854755 
                 A 
                 0.198 
                 10589 
                 2.65E−03 
                 1.16 
                 0.222 
                 1694 
                 7.15E−03 
                 1.13 
                 0.218 
                 2027 
               
               
                 C09 
                 79420643 
                 rs10867740 
                 C 
                 0.236 
                 10625 
                 2.65E−03 
                 1.15 
                 0.262 
                 1699 
                 2.00E−03 
                 1.14 
                 0.261 
                 2033 
               
               
                 C20 
                 53952228 
                 rs6068930 
                 G 
                 0.039 
                 10620 
                 2.66E−03 
                 1.32 
                 0.051 
                 1700 
                 9.79E−03 
                 1.26 
                 0.049 
                 2034 
               
               
                 C14 
                 68370111 
                 rs1291302 
                 C 
                 0.259 
                 10527 
                 2.66E−03 
                 1.14 
                 0.285 
                 1675 
                 3.98E−03 
                 1.13 
                 0.282 
                 2008 
               
               
                 C01 
                 93943749 
                 rs4147861 
                 G 
                 0.923 
                 10526 
                 2.66E−03 
                 1.27 
                 0.939 
                 1668 
                 2.12E−03 
                 1.25 
                 0.938 
                 2000 
               
               
                 C14 
                 98178185 
                 rs2273840 
                 A 
                 0.931 
                 10569 
                 2.67E−03 
                 1.28 
                 0.945 
                 1677 
                 1.07E−03 
                 1.29 
                 0.945 
                 2009 
               
               
                 C14 
                 98178185 
                 rs2273840 
                 A 
                 0.931 
                 10569 
                 2.67E−03 
                 1.28 
                 0.945 
                 1677 
                 1.07E−03 
                 1.29 
                 0.945 
                 2009 
               
               
                 CX 
                 138713457 
                 rs1948488 
                 A 
                 0.223 
                 8219 
                 2.68E−03 
                 1.19 
                 0.254 
                 1094 
                 4.52E−03 
                 1.16 
                 0.25 
                 1307 
               
               
                 C12 
                 20196656 
                 rs7299937 
                 T 
                 0.059 
                 10635 
                 2.68E−03 
                 1.26 
                 0.074 
                 1700 
                 7.12E−03 
                 1.22 
                 0.071 
                 2034 
               
               
                 C04 
                 87630493 
                 rs10516770 
                 T 
                 0.055 
                 10635 
                 2.69E−03 
                 1.27 
                 0.069 
                 1700 
                 4.44E−03 
                 1.24 
                 0.067 
                 2034 
               
               
                 C02 
                 172822314 
                 rs4668412 
                 A 
                 0.709 
                 10634 
                 2.69E−03 
                 1.14 
                 0.736 
                 1700 
                 4.24E−03 
                 1.12 
                 0.733 
                 2034 
               
               
                 C06 
                 36770559 
                 rs236444 
                 T 
                 0.253 
                 10634 
                 2.70E−03 
                 1.14 
                 0.279 
                 1700 
                 3.68E−04 
                 1.16 
                 0.281 
                 2034 
               
               
                 C11 
                 103253198 
                 rs10502020 
                 G 
                 0.446 
                 10634 
                 2.71E−03 
                 1.13 
                 0.476 
                 1700 
                 8.02E−03 
                 1.1 
                 0.47 
                 2034 
               
               
                 C04 
                 131653392 
                 rs4383635 
                 A 
                 0.491 
                 10630 
                 2.71E−03 
                 1.13 
                 0.521 
                 1699 
                 2.25E−03 
                 1.12 
                 0.519 
                 2033 
               
               
                 C04 
                 87557966 
                 rs2199309 
                 C 
                 0.229 
                 10234 
                 2.71E−03 
                 1.15 
                 0.255 
                 1653 
                 8.94E−04 
                 1.15 
                 0.256 
                 1977 
               
               
                 C09 
                 23737791 
                 rs1329044 
                 C 
                 0.153 
                 10631 
                 2.71E−03 
                 1.17 
                 0.175 
                 1700 
                 6.15E−04 
                 1.18 
                 0.176 
                 2034 
               
               
                 C12 
                 127797687 
                 rs470477 
                 T 
                 0.311 
                 10632 
                 2.71E−03 
                 1.13 
                 0.338 
                 1700 
                 5.14E−03 
                 1.12 
                 0.334 
                 2033 
               
               
                 C13 
                 105492839 
                 rs1927771 
                 A 
                 0.411 
                 10633 
                 2.72E−03 
                 1.13 
                 0.44 
                 1700 
                 4.66E−03 
                 1.11 
                 0.436 
                 2034 
               
               
                 CX 
                 4916022 
                 rs6638525 
                 C 
                 0.107 
                 8269 
                 2.73E−03 
                 1.25 
                 0.13 
                 1103 
                 1.91E−03 
                 1.24 
                 0.129 
                 1316 
               
               
                 C09 
                 134921961 
                 rs2297538 
                 G 
                 0.73 
                 10630 
                 2.75E−03 
                 1.15 
                 0.756 
                 11700 
                 5.61E−03 
                 1.12 
                 0.752 
                 2034 
               
               
                 C11 
                 68645465 
                 rs2924536 
                 A 
                 0.447 
                 10631 
                 2.75E−03 
                 1.13 
                 0.476 
                 1700 
                 1.83E−02 
                 1.09 
                 0.469 
                 2034 
               
               
                 C02 
                 173022859 
                 rs10165126 
                 C 
                 0.705 
                 10630 
                 2.75E−03 
                 1.14 
                 0.732 
                 1699 
                 2.98E−03 
                 1.13 
                 0.729 
                 2033 
               
               
                 C11 
                 10906227 
                 rs10500734 
                 A 
                 0.767 
                 10617 
                 2.75E−03 
                 1.15 
                 0.791 
                 1692 
                 2.25E−02 
                 1.11 
                 0.784 
                 2025 
               
               
                 C02 
                 12183852 
                 rs10929777 
                 C 
                 0.3 
                 10634 
                 2.75E−03 
                 1.14 
                 0.327 
                 1700 
                 7.76E−03 
                 1.11 
                 0.323 
                 2034 
               
               
                 C01 
                 106549733 
                 rs10494048 
                 T 
                 0.387 
                 10589 
                 2.75E−03 
                 1.13 
                 0.416 
                 1699 
                 2.94E−02 
                 1.08 
                 0.406 
                 2030 
               
               
                 C10 
                 69228609 
                 rs17456902 
                 G 
                 0.872 
                 10635 
                 2.76E−03 
                 1.2 
                 0.891 
                 1700 
                 3.98E−03 
                 1.18 
                 0.889 
                 2034 
               
               
                 C04 
                 90099908 
                 rs2924936 
                 G 
                 0.869 
                 10635 
                 2.76E−03 
                 1.2 
                 0.888 
                 1700 
                 3.77E−04 
                 1.22 
                 0.89 
                 2034 
               
               
                 C06 
                 37561316 
                 rs9296225 
                 C 
                 0.472 
                 10635 
                 2.76E−03 
                 1.13 
                 0.502 
                 1700 
                 3.40E−03 
                 1.11 
                 0.499 
                 2034 
               
               
                 C22 
                 17337894 
                 rs2019061 
                 T 
                 0.685 
                 10621 
                 2.77E−03 
                 1.14 
                 0.712 
                 1694 
                 6.23E−03 
                 1.12 
                 0.708 
                 2028 
               
               
                 C02 
                 16792100 
                 rs11897395 
                 C 
                 0.889 
                 10590 
                 2.77E−03 
                 1.22 
                 0.907 
                 1686 
                 1.35E−02 
                 1.16 
                 0.903 
                 2020 
               
               
                 C02 
                 43918060 
                 rs1991739 
                 A 
                 0.619 
                 10632 
                 2.77E−03 
                 1.13 
                 0.647 
                 1700 
                 1.72E−02 
                 1.09 
                 0.64 
                 2034 
               
               
                 C07 
                 102594288 
                 rs7804867 
                 A 
                 0.205 
                 10634 
                 2.78E−03 
                 1.15 
                 0.229 
                 1700 
                 1.92E−03 
                 1.15 
                 0.228 
                 2034 
               
               
                 C06 
                 10170597 
                 rs6459613 
                 A 
                 0.545 
                 10601 
                 2.78E−03 
                 1.13 
                 0.574 
                 1698 
                 2.65E−02 
                 1.09 
                 0.565 
                 2030 
               
               
                 C05 
                 50904720 
                 rs7708362 
                 T 
                 0.345 
                 10619 
                 2.78E−03 
                 1.13 
                 0.373 
                 1687 
                 5.55E−03 
                 1.11 
                 0.369 
                 2021 
               
               
                 C05 
                 94682297 
                 rs464906 
                 C 
                 0.614 
                 10630 
                 2.78E−03 
                 1.13 
                 0.642 
                 1700 
                 9.79E−03 
                 1.1 
                 0.637 
                 2034 
               
               
                 C10 
                 8311160 
                 rs1419294 
                 T 
                 0.711 
                 10635 
                 2.78E−03 
                 1.14 
                 0.738 
                 1700 
                 1.09E−03 
                 1.14 
                 0.738 
                 2034 
               
               
                 C10 
                 2108862 
                 rs12776254 
                 G 
                 0.167 
                 10634 
                 2.78E−03 
                 1.17 
                 0.19 
                 1700 
                 1.95E−03 
                 1.16 
                 0.189 
                 2034 
               
               
                 C20 
                 59771295 
                 rs6128843 
                 T 
                 0.182 
                 10634 
                 2.79E−03 
                 1.16 
                 0.206 
                 1700 
                 1.16E−03 
                 1.16 
                 0.206 
                 2034 
               
               
                 C02 
                 242432072 
                 rs12052982 
                 A 
                 0.958 
                 10630 
                 2.79E−03 
                 1.38 
                 0.969 
                 1698 
                 7.24E−03 
                 1.3 
                 0.967 
                 2032 
               
               
                 C10 
                 102016372 
                 rs9420802 
                 G 
                 0.209 
                 10632 
                 2.80E−03 
                 1.15 
                 0.233 
                 1698 
                 1.15E−02 
                 1.12 
                 0.228 
                 2032 
               
               
                 C07 
                 149980541 
                 rs10277774 
                 C 
                 0.383 
                 10632 
                 2.80E−03 
                 1.13 
                 0.412 
                 1699 
                 1.84E−03 
                 1.12 
                 0.411 
                 2033 
               
               
                 C12 
                 21065184 
                 rs1910186 
                 C 
                 0.109 
                 10630 
                 2.80E−03 
                 1.2 
                 0.128 
                 1700 
                 1.84E−03 
                 1.19 
                 0.128 
                 2034 
               
               
                 C12 
                 21065184 
                 rs1910186 
                 C 
                 0.109 
                 10630 
                 2.80E−03 
                 1.2 
                 0.128 
                 1700 
                 1.84E−03 
                 1.19 
                 0.128 
                 2034 
               
               
                 C17 
                 73745676 
                 rs1000299 
                 A 
                 0.055 
                 10635 
                 2.81E−03 
                 1.27 
                 0.069 
                 1700 
                 2.50E−02 
                 1.19 
                 0.064 
                 2034 
               
               
                 C06 
                 162143621 
                 rs7739802 
                 T 
                 0.491 
                 10594 
                 2.81E−03 
                 1.12 
                 0.521 
                 1699 
                 4.70E−04 
                 1.14 
                 0.523 
                 2030 
               
               
                 C11 
                 102072274 
                 rs1276252 
                 G 
                 0.252 
                 10634 
                 2.81E−03 
                 1.14 
                 0.277 
                 1700 
                 1.08E−02 
                 1.11 
                 0.272 
                 2034 
               
               
                 C12 
                 123335210 
                 rs3759107 
                 T 
                 0.127 
                 10635 
                 2.81E−03 
                 1.19 
                 0.147 
                 1700 
                 3.67E−03 
                 1.17 
                 0.145 
                 2034 
               
               
                 C11 
                 42941748 
                 rs7939657 
                 T 
                 0.558 
                 10632 
                 2.81E−03 
                 1.13 
                 0.587 
                 1700 
                 3.56E−03 
                 1.11 
                 0.585 
                 2034 
               
               
                 C14 
                 63855666 
                 rs7147624 
                 G 
                 0.798 
                 10635 
                 2.81E−03 
                 1.16 
                 0.821 
                 1700 
                 3.48E−03 
                 1.15 
                 0.819 
                 2034 
               
               
                 C07 
                 21959042 
                 rs17146355 
                 A 
                 0.05 
                 10619 
                 2.82E−03 
                 1.29 
                 0.063 
                 1697 
                 1.93E−03 
                 1.28 
                 0.063 
                 2031 
               
               
                 C01 
                 7589173 
                 rs10462018 
                 C 
                 0.816 
                 10632 
                 2.82E−03 
                 1.17 
                 0.839 
                 1700 
                 1.67E−02 
                 1.12 
                 0.833 
                 2034 
               
               
                 C15 
                 87930503 
                 rs12595195 
                 C 
                 0.275 
                 10632 
                 2.82E−03 
                 1.14 
                 0.301 
                 1700 
                 5.15E−03 
                 1.12 
                 0.298 
                 2034 
               
               
                 C04 
                 90107239 
                 rs13130 
                 T 
                 0.87 
                 10623 
                 2.82E−03 
                 1.2 
                 0.889 
                 1698 
                 3.57E−04 
                 1.22 
                 0.891 
                 2032 
               
               
                 C03 
                 99664143 
                 rs1531377 
                 T 
                 0.173 
                 10628 
                 2.83E−03 
                 1.16 
                 0.196 
                 1699 
                 1.02E−02 
                 1.13 
                 0.191 
                 2033 
               
               
                 C04 
                 30136639 
                 rs2060515 
                 T 
                 0.111 
                 10569 
                 2.83E−03 
                 1.2 
                 0.13 
                 1689 
                 4.85E−03 
                 1.17 
                 0.127 
                 2020 
               
               
                 C18 
                 58447316 
                 rs2332575 
                 A 
                 0.053 
                 10634 
                 2.84E−03 
                 1.28 
                 0.066 
                 1699 
                 2.85E−03 
                 1.26 
                 0.065 
                 2033 
               
               
                 C06 
                 12338790 
                 rs1028716 
                 T 
                 0.06 
                 10632 
                 2.84E−03 
                 1.26 
                 0.074 
                 1700 
                 4.77E−03 
                 1.23 
                 0.072 
                 2034 
               
               
                 C05 
                 55657524 
                 rs32496 
                 C 
                 0.573 
                 10633 
                 2.85E−03 
                 1.13 
                 0.601 
                 1700 
                 4.48E−03 
                 1.11 
                 0.598 
                 2034 
               
               
                 C08 
                 5835084 
                 rs890014 
                 C 
                 0.757 
                 10635 
                 2.86E−03 
                 1.15 
                 0.781 
                 1700 
                 4.61E−03 
                 1.13 
                 0.779 
                 2034 
               
               
                 C21 
                 14821123 
                 rs2822744 
                 A 
                 0.157 
                 10633 
                 2.86E−03 
                 1.17 
                 0.179 
                 1700 
                 4.96E−03 
                 1.15 
                 0.176 
                 2034 
               
               
                 C06 
                 19958854 
                 rs6905466 
                 T 
                 0.327 
                 10635 
                 2.86E−03 
                 1.13 
                 0.355 
                 1700 
                 1.18E−03 
                 1.13 
                 0.355 
                 2034 
               
               
                 C15 
                 77441636 
                 rs4255747 
                 G 
                 0.668 
                 10635 
                 2.86E−03 
                 1.13 
                 0.695 
                 1700 
                 1.01E−02 
                 1.11 
                 0.69 
                 2034 
               
               
                 C15 
                 53381369 
                 rs8041044 
                 C 
                 0.914 
                 10627 
                 2.86E−03 
                 1.25 
                 0.93 
                 1698 
                 1.09E−02 
                 1.19 
                 0.927 
                 2032 
               
               
                 C02 
                 24312396 
                 rs10200481 
                 A 
                 0.106 
                 10635 
                 2.86E−03 
                 1.2 
                 0.125 
                 1700 
                 1.22E−02 
                 1.15 
                 0.121 
                 2033 
               
               
                 C10 
                 16380276 
                 rs2184383 
                 G 
                 0.805 
                 10628 
                 2.87E−03 
                 1.16 
                 0.828 
                 1700 
                 4.18E−03 
                 1.14 
                 0.825 
                 2034 
               
               
                 C09 
                 8506194 
                 rs10119236 
                 A 
                 0.294 
                 10632 
                 2.87E−03 
                 1.14 
                 0.321 
                 1700 
                 2.66E−02 
                 1.09 
                 0.312 
                 2034 
               
               
                 C02 
                 78341614 
                 rs2861264 
                 T 
                 0.105 
                 10635 
                 2.87E−03 
                 1.2 
                 0.123 
                 1700 
                 3.16E−03 
                 1.18 
                 0.122 
                 2034 
               
               
                 C18 
                 58394216 
                 rs3744927 
                 G 
                 0.773 
                 10634 
                 2.88E−03 
                 1.15 
                 0.797 
                 1700 
                 1.35E−02 
                 1.12 
                 0.792 
                 2034 
               
               
                 C02 
                 77756026 
                 rs6547152 
                 C 
                 0.787 
                 10620 
                 2.89E−03 
                 1.16 
                 0.811 
                 1698 
                 1.38E−03 
                 1.16 
                 0.811 
                 2032 
               
               
                 C12 
                 52445647 
                 rs6580960 
                 A 
                 0.541 
                 10635 
                 2.89E−03 
                 1.13 
                 0.57 
                 1700 
                 3.40E−03 
                 1.11 
                 0.567 
                 2034 
               
               
                 C07 
                 27780647 
                 rs740127 
                 G 
                 0.595 
                 10635 
                 2.89E−03 
                 1.13 
                 0.624 
                 1700 
                 1.23E−02 
                 1.1 
                 0.618 
                 2034 
               
               
                 C07 
                 50816853 
                 rs17134122 
                 A 
                 0.966 
                 10634 
                 2.89E−03 
                 1.43 
                 0.976 
                 1700 
                 1.10E−02 
                 1.32 
                 0.974 
                 2034 
               
               
                 C22 
                 34868465 
                 rs132717 
                 C 
                 0.62 
                 10359 
                 2.90E−03 
                 1.13 
                 0.648 
                 1664 
                 2.36E−02 
                 1.09 
                 0.64 
                 1990 
               
               
                 C18 
                 55211067 
                 rs8088514 
                 C 
                 0.461 
                 10602 
                 2.90E−03 
                 1.12 
                 0.49 
                 1693 
                 1.65E−02 
                 1.09 
                 0.482 
                 2027 
               
               
                 C10 
                 119681455 
                 rs7922488 
                 G 
                 0.533 
                 10616 
                 2.90E−03 
                 1.13 
                 0.562 
                 1692 
                 4.75E−03 
                 1.11 
                 0.558 
                 2026 
               
               
                 C05 
                 158745072 
                 rs7709212 
                 T 
                 0.678 
                 10635 
                 2.90E−03 
                 1.14 
                 0.705 
                 1700 
                 1.55E−02 
                 1.1 
                 0.699 
                 2034 
               
               
                 C05 
                 23761851 
                 rs11743379 
                 T 
                 0.507 
                 10633 
                 2.91E−03 
                 1.12 
                 0.536 
                 1700 
                 4.46E−04 
                 1.14 
                 0.539 
                 2034 
               
               
                 C06 
                 130039640 
                 rs376632 
                 G 
                 0.89 
                 10633 
                 2.91E−03 
                 1.22 
                 0.908 
                 1699 
                 2.60E−03 
                 1.2 
                 0.907 
                 2033 
               
               
                 C10 
                 8277669 
                 rs4747760 
                 G 
                 0.875 
                 10631 
                 2.91E−03 
                 1.2 
                 0.894 
                 1700 
                 3.50E−03 
                 1.18 
                 0.892 
                 2034 
               
               
                 C03 
                 145966921 
                 rs13061557 
                 T 
                 0.699 
                 10630 
                 2.91E−03 
                 1.14 
                 0.726 
                 1700 
                 1.57E−02 
                 1.1 
                 0.719 
                 2034 
               
               
                 C06 
                 122997014 
                 rs9388117 
                 A 
                 0.671 
                 10616 
                 2.92E−03 
                 1.13 
                 0.698 
                 1699 
                 1.83E−02 
                 1.1 
                 0.691 
                 2033 
               
               
                 C10 
                 132443494 
                 rs893504 
                 C 
                 0.071 
                 10635 
                 2.92E−03 
                 1.24 
                 0.087 
                 1700 
                 2.64E−03 
                 1.22 
                 0.086 
                 2034 
               
               
                 C04 
                 40312795 
                 rs4447895 
                 C 
                 0.888 
                 10634 
                 2.92E−03 
                 1.22 
                 0.906 
                 1700 
                 1.56E−03 
                 1.21 
                 0.906 
                 2034 
               
               
                 C06 
                 162147237 
                 rs3016536 
                 G 
                 0.517 
                 10635 
                 2.93E−03 
                 1.12 
                 0.546 
                 1700 
                 1.72E−03 
                 1.12 
                 0.545 
                 2034 
               
               
                 C15 
                 58046702 
                 rs4775234 
                 C 
                 0.259 
                 10530 
                 2.93E−03 
                 1.14 
                 0.285 
                 1681 
                 3.63E−02 
                 1.09 
                 0.276 
                 2009 
               
               
                 C10 
                 107117270 
                 rs11192557 
                 T 
                 0.876 
                 10623 
                 2.93E−03 
                 1.2 
                 0.895 
                 1698 
                 2.56E−03 
                 1.19 
                 0.893 
                 2032 
               
               
                 C07 
                 1681599 
                 rs10267593 
                 G 
                 0.835 
                 10635 
                 2.93E−03 
                 1.18 
                 0.856 
                 1700 
                 2.02E−04 
                 1.21 
                 0.859 
                 2034 
               
               
                 C14 
                 98123983 
                 rs2895811 
                 C 
                 0.448 
                 10607 
                 3.04E−03 
                 1.12 
                 0.478 
                 1694 
                 3.73E−03 
                 1.11 
                 0.475 
                 2027 
               
               
                 C17 
                 18260758 
                 rs854771 
                 C 
                 0.554 
                 10635 
                 3.18E−03 
                 1.12 
                 0.583 
                 1700 
                 1.54E−03 
                 1.12 
                 0.583 
                 2034 
               
               
                 C04 
                 129890119 
                 rs4549394 
                 T 
                 0.097 
                 10631 
                 3.31E−03 
                 1.21 
                 0.115 
                 1700 
                 2.25E−03 
                 1.2 
                 0.114 
                 2034 
               
               
                 C02 
                 176994186 
                 rs12621733 
                 G 
                 0.899 
                 10634 
                 3.47E−03 
                 1.22 
                 0.916 
                 1700 
                 9.37E−04 
                 1.24 
                 0.917 
                 2034 
               
               
                 C01 
                 113692475 
                 rs1217407 
                 A 
                 0.249 
                 10631 
                 3.56E−03 
                 1.14 
                 0.274 
                 1700 
                 1.20E−03 
                 1.14 
                 0.275 
                 2034 
               
               
                 C02 
                 36037410 
                 rs10203034 
                 A 
                 0.68 
                 10634 
                 3.64E−03 
                 1.13 
                 0.706 
                 1700 
                 2.27E−03 
                 1.13 
                 0.706 
                 2034 
               
               
                 C01 
                 113628929 
                 rs2797409 
                 C 
                 0.249 
                 10634 
                 3.79E−03 
                 1.14 
                 0.274 
                 1700 
                 1.29E−03 
                 1.14 
                 0.275 
                 2034 
               
               
                 C12 
                 69325443 
                 rs7978668 
                 T 
                 0.918 
                 10635 
                 3.84E−03 
                 1.25 
                 0.933 
                 1700 
                 1.61E−03 
                 1.25 
                 0.933 
                 2034 
               
               
                 C12 
                 69326403 
                 rs767760 
                 A 
                 0.914 
                 10635 
                 3.96E−03 
                 1.24 
                 0.93 
                 1700 
                 1.10E−03 
                 1.25 
                 0.93 
                 2034 
               
               
                 C12 
                 69368222 
                 rs949664 
                 A 
                 0.863 
                 10632 
                 3.98E−03 
                 1.19 
                 0.882 
                 1700 
                 1.46E−03 
                 1.19 
                 0.882 
                 2034 
               
               
                 C12 
                 69340682 
                 rs7309888 
                 C 
                 0.794 
                 10631 
                 4.11E−03 
                 1.15 
                 0.816 
                 1700 
                 1.40E−03 
                 1.16 
                 0.817 
                 2034 
               
               
                 C14 
                 98160936 
                 rs12435918 
                 G 
                 0.333 
                 10635 
                 4.43E−03 
                 1.12 
                 0.36 
                 1700 
                 2.64E−03 
                 1.12 
                 0.359 
                 2034 
               
               
                 C07 
                 11669876 
                 rs2355129 
                 A 
                 0.362 
                 10635 
                 4.59E−03 
                 1.12 
                 0.389 
                 1699 
                 1.13E−03 
                 1.13 
                 0.391 
                 2033 
               
               
                 C08 
                 129057022 
                 rs2648896 
                 C 
                 0.149 
                 10633 
                 5.75E−03 
                 1.16 
                 0.169 
                 1700 
                 2.49E−03 
                 1.16 
                 0.169 
                 2034 
               
               
                 C12 
                 69347673 
                 rs7976576 
                 T 
                 0.794 
                 10635 
                 6.31E−03 
                 1.15 
                 0.816 
                 1700 
                 2.22E−03 
                 1.15 
                 0.816 
                 2034 
               
               
                 C07 
                 11658292 
                 rs10215881 
                 C 
                 0.494 
                 10630 
                 8.18E−03 
                 1.11 
                 0.52 
                 1699 
                 1.88E−03 
                 1.12 
                 0.523 
                 2033 
               
               
                 C12 
                 124462726 
                 rs7310042 
                 G 
                 0.193 
                 10634 
                 8.35E−03 
                 1.14 
                 0.214 
                 1700 
                 2.55E−03 
                 1.15 
                 0.215 
                 2034 
               
               
                 C07 
                 11646149 
                 rs6460851 
                 G 
                 0.288 
                 10624 
                 8.43E−03 
                 1.12 
                 0.312 
                 1698 
                 1.88E−03 
                 1.13 
                 0.314 
                 2031 
               
               
                 C02 
                 128444077 
                 rs46627431 
                 T 
                 0.515 
                 10622 
                 1.30E−02 
                 1.1 
                 0.539 
                 1700 
                 2.49E−03 
                 1.12 
                 0.543 
                 2034 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Association results for the Icelandic discovery cohorts, and the replication cohorts. The 
               
               
                 columns in the table indicate (1) the cohort, (2) rs name of the marker in question, 
               
               
                 (3) the chromosome, (4) position of the marker in NCBI Build 34, (5) p-value of the 
               
               
                 association, (6) the Relative Risk of the association, (7) the number of MI patients, 
               
               
                 (8) the frequency of the associating allele in patients, (9) the number of controls, 
               
               
                 (10) the frequency of the associating allele in controls, (11) the associating allele. 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Cohort 
                 rs-name 
                 chr 
                 position 
                 p-value 
                 RR 
                 Naff 
                 f (aff) 
                 Ncon 
                 f (con) 
                 allele 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 SG01S1480 
                   
                 C01 
                 57254228 
                   
                   
                   
                   
                   
                   
                   
               
               
                 Iceland discovery group 
                 rs2991515 
                   
                   
                 0.001045 
                 1.14 
                 1642 
                 0.514 
                 6868 
                 0.480 
                 T 
               
               
                 Iceland replication group 
                 rs2991515 
                   
                   
                 0.054380 
                 1.13 
                 560 
                 0.507 
                 3393 
                 0.476 
                 T 
               
               
                 Iceland All 
                 rs2991515 
                   
                   
                 0.000108 
                 1.14 
                 2202 
                 0.512 
                 10261 
                 0.479 
                 T 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                   
                   
                   
                 NA 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 NA 
                 NA 
                 NA 
               
               
                 All replication groups 
                   
                   
                   
                 0.054379 
                 1.13 
                 544 
                   
                   
                   
                 T 
               
               
                 All groups 
                   
                   
                   
                 0.000108 
                 1.14 
                 2016 
                   
                   
                   
                 T 
               
               
                 SG01S1340 
                   
                 C01 
                 113676295 
               
               
                 Iceland discovery group 
                 rs2476601 
                   
                   
                 0.000452 
                 1.23 
                 1632 
                 0.156 
                 6858 
                 0.130 
                 A 
               
               
                 Iceland replication group 
                 rs2476601 
                   
                   
                 0.001253 
                 1.34 
                 562 
                 0.167 
                 3393 
                 0.130 
                 A 
               
               
                 Iceland All 
                 rs2476601 
                   
                   
                 0.000003 
                 1.26 
                 2194 
                 0.159 
                 10251 
                 0.130 
                 A 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                   
                   
                   
                 NA 
               
               
                 Durham 
                 rs2476601 
                   
                   
                 0.407813 
                 1.12 
                 932 
                 0.095 
                 544 
                 0.086 
                 A 
               
               
                 All US groups 
                   
                   
                   
                 0.407813 
                 1.1164 
                 932 
                   
                   
                   
                 A 
               
               
                 All replication groups 
                   
                   
                   
                 0.001741 
                 1.2678 
                 1478 
                   
                   
                   
                 A 
               
               
                 All groups 
                   
                   
                   
                 0.000003 
                 1.2404 
                 2941 
                   
                   
                   
                 A 
               
               
                 SG02S870 
                   
                 C02 
                 36022756 
               
               
                 Iceland discovery group 
                 rs6747236 
                   
                   
                 0.004309 
                 1.14 
                 1634 
                 0.743 
                 6863 
                 0.717 
                 T 
               
               
                 Iceland replication group 
                 rs6747236 
                   
                   
                 0.101400 
                 1.13 
                 544 
                 0.741 
                 3391 
                 0.717 
                 T 
               
               
                 Iceland All 
                 rs6747236 
                   
                   
                 0.000905 
                 1.14 
                 2178 
                 0.742 
                 10254 
                 0.717 
                 T 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                   
                   
                   
                 NA 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 NA 
                 NA 
                 NA 
               
               
                 All replication groups 
                   
                   
                   
                 0.101403 
                 1.13 
                 528 
                   
                   
                   
                 T 
               
               
                 All groups 
                   
                   
                   
                 0.000905 
                 1.14 
                 1994 
                   
                   
                   
                 T 
               
               
                 SG02S840 
                   
                 C02 
                 176947426 
               
               
                 Iceland discovery group 
                 rs921083 
                   
                   
                 0.000163 
                 1.21 
                 1642 
                 0.806 
                 6867 
                 0.774 
                 G 
               
               
                 Iceland replication group 
                 rs921083 
                   
                   
                 0.054180 
                 1.17 
                 549 
                 0.805 
                 3392 
                 0.779 
                 G 
               
               
                 Iceland All 
                 rs921083 
                   
                   
                 0.000025 
                 1.20 
                 2191 
                 0.806 
                 10259 
                 0.776 
                 G 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                   
                   
                   
                 NA 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 NA 
                 NA 
                 NA 
               
               
                 All replication groups 
                   
                   
                   
                 0.054178 
                 1.17 
                 533 
                   
                   
                   
                 G 
               
               
                 All groups 
                   
                   
                   
                 0.000025 
                 1.20 
                 2006 
                   
                   
                   
                 G 
               
               
                 SG02S832 
                   
                 C02 
                 212588265 
               
               
                 Iceland discovery group 
                 rs12329252 
                   
                   
                 0.000680 
                 1.16 
                 1641 
                 0.710 
                 6868 
                 0.677 
                 T 
               
               
                 Iceland replication group 
                 rs12329252 
                   
                   
                 0.327900 
                 1.07 
                 554 
                 0.692 
                 3393 
                 0.677 
                 T 
               
               
                 Iceland All 
                 rs12329252 
                   
                   
                 0.000500 
                 1.14 
                 2195 
                 0.705 
                 10261 
                 0.677 
                 T 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                   
                   
                   
                 NA 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 NA 
                 NA 
                 NA 
               
               
                 All replication groups 
                   
                   
                   
                 0.327938 
                 1.07 
                 538 
                   
                   
                   
                 T 
               
               
                 All groups 
                   
                   
                   
                 0.000500 
                 1.14 
                 2010 
                   
                   
                   
                 T 
               
               
                 SG03S670 
                   
                 C03 
                 62420156 
               
               
                 Iceland discovery group 
                 rs9874646 
                   
                   
                 0.000330 
                 1.18 
                 1642 
                 0.746 
                 6867 
                 0.713 
                 T 
               
               
                 Iceland replication group 
                 rs9874646 
                   
                   
                 0.173800 
                 1.10 
                 555 
                 0.721 
                 3393 
                 0.700 
                 T 
               
               
                 Iceland All 
                 rs9874646 
                   
                   
                 0.000078 
                 1.17 
                 2197 
                 0.739 
                 10260 
                 0.709 
                 T 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                   
                   
                   
                 NA 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 NA 
                 NA 
                 NA 
               
               
                 All replication groups 
                   
                   
                   
                 0.173753 
                 1.10 
                 539 
                   
                   
                   
                 T 
               
               
                 All groups 
                   
                   
                   
                 0.000078 
                 1.17 
                 2012 
                   
                   
                   
                 T 
               
               
                 SG03S671 
                   
                 C03 
                 191533619 
               
               
                 Iceland discovery group 
                 rs9864293 
                   
                   
                 0.007956 
                 1.12 
                 1624 
                 0.418 
                 6866 
                 0.391 
                 C 
               
               
                 Iceland replication group 
                 rs9864293 
                   
                   
                 0.143800 
                 1.22 
                 119 
                 0.424 
                 3392 
                 0.377 
                 C 
               
               
                 Iceland All 
                 rs9864293 
                   
                   
                 0.000591 
                 1.14 
                 1743 
                 0.419 
                 10258 
                 0.386 
                 C 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                   
                   
                   
                 NA 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 NA 
                 NA 
                 NA 
               
               
                 All replication groups 
                   
                   
                   
                 0.143805 
                 1.22 
                 115 
                   
                   
                   
                 C 
               
               
                 All groups 
                   
                   
                   
                 0.000591 
                 1.14 
                 1596 
                   
                   
                   
                 C 
               
               
                 SG04S816 
                   
                 C04 
                 21568604 
               
               
                 Iceland discovery group 
                 rs4282162 
                   
                   
                 0.000562 
                 1.15 
                 1641 
                 0.565 
                 6867 
                 0.529 
                 T 
               
               
                 Iceland replication group 
                 rs4282162 
                   
                   
                 0.221000 
                 1.08 
                 559 
                 0.547 
                 3393 
                 0.527 
                 T 
               
               
                 Iceland All 
                 rs4282162 
                   
                   
                 0.000244 
                 1.14 
                 2200 
                 0.560 
                 10260 
                 0.528 
                 T 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                   
                   
                   
                 NA 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 NA 
                 NA 
                 NA 
               
               
                 All replication groups 
                   
                   
                   
                 0.221045 
                 1.08 
                 543 
                   
                   
                   
                 T 
               
               
                 All groups 
                   
                   
                   
                 0.000244 
                 1.14 
                 2014 
                   
                   
                   
                 T 
               
               
                 SG04S820 
                   
                 C04 
                 45948792 
               
               
                 Iceland discovery group 
                 rs7661204 
                   
                   
                 0.034390 
                 1.09 
                 1641 
                 0.576 
                 6868 
                 0.555 
                 C 
               
               
                 Iceland replication group 
                 rs7661204 
                   
                   
                 0.026880 
                 1.16 
                 562 
                 0.583 
                 3393 
                 0.547 
                 C 
               
               
                 Iceland All 
                 rs7661204 
                   
                   
                 0.002633 
                 1.11 
                 2203 
                 0.578 
                 10261 
                 0.552 
                 C 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                   
                   
                   
                 NA 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 NA 
                 NA 
                 NA 
               
               
                 All replication groups 
                   
                   
                   
                 0.026881 
                 1.16 
                 546 
                   
                   
                   
                 C 
               
               
                 All groups 
                   
                   
                   
                 0.002633 
                 1.11 
                 2017 
                   
                   
                   
                 C 
               
               
                 SG05S3061 
                   
                 C05 
                 118135750 
               
               
                 Iceland discovery group 
                 rs728676 
                   
                   
                 0.003297 
                 1.13 
                 1641 
                 0.470 
                 6868 
                 0.440 
                 T 
               
               
                 Iceland replication group 
                 rs728676 
                   
                   
                 0.011820 
                 1.18 
                 561 
                 0.482 
                 3392 
                 0.441 
                 T 
               
               
                 Iceland All 
                 rs728676 
                   
                   
                 0.000145 
                 1.14 
                 2202 
                 0.473 
                 10260 
                 0.440 
                 T 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                 rs728676 
                   
                   
                 0.101514 
                 1.14 
                 464 
                 0.498 
                 1012 
                 0.465 
                 T 
               
               
                 Durham 
                 rs728676 
                   
                   
                 0.596462 
                 0.97 
                 1168 
                 0.484 
                 718 
                 0.493 
                 T 
               
               
                 All US groups 
                   
                   
                   
                 0.513855 
                 1.03 
                 1632 
                   
                   
                   
                 T 
               
               
                 All replication groups 
                   
                   
                   
                 0.038993 
                 1.09 
                 2177 
                   
                   
                   
                 T 
               
               
                 All groups 
                   
                   
                   
                 0.000449 
                 1.11 
                 3648 
                   
                   
                   
                 T 
               
               
                 SG05S3058 
                   
                 C05 
                 158504417 
               
               
                 Iceland discovery group 
                 rs7442701 
                   
                   
                 0.000114 
                 1.22 
                 1625 
                 0.208 
                 6865 
                 0.176 
                 T 
               
               
                 Iceland replication group 
                 rs7442701 
                   
                   
                 0.913600 
                 1.02 
                 120 
                 0.175 
                 3390 
                 0.172 
                 T 
               
               
                 Iceland All 
                 rs7442701 
                   
                   
                 0.000045 
                 1.22 
                 1745 
                 0.205 
                 10255 
                 0.175 
                 T 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                   
                   
                   
                 NA 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 NA 
                 NA 
                 NA 
               
               
                 All replication groups 
                   
                   
                   
                 0.913822 
                 1.02 
                 116 
                   
                   
                   
                 T 
               
               
                 All groups 
                   
                   
                   
                 0.000045 
                 1.22 
                 1598 
                   
                   
                   
                 T 
               
               
                 SG06S1298 
                   
                 C06 
                 29516393 
               
               
                 Iceland discovery group 
                 rs2074464 
                   
                   
                 0.002492 
                 1.13 
                 1633 
                 0.475 
                 6862 
                 0.444 
                 T 
               
               
                 Iceland replication group 
                 rs2074464 
                   
                   
                 0.191700 
                 1.09 
                 545 
                 0.466 
                 3390 
                 0.445 
                 T 
               
               
                 Iceland All 
                 rs2074464 
                   
                   
                 0.000945 
                 1.12 
                 2178 
                 0.473 
                 10252 
                 0.444 
                 T 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                 rs2074464 
                   
                   
                 0.076812 
                 1.18 
                 365 
                 0.484 
                 576 
                 0.442 
                 T 
               
               
                 Durham 
                 rs2074464 
                   
                   
                 0.290169 
                 1.07 
                 1200 
                 0.469 
                 728 
                 0.451 
                 T 
               
               
                 All US groups 
                   
                   
                   
                 0.059737 
                 1.11 
                 1565 
                   
                   
                   
                 T 
               
               
                 All replication groups 
                   
                   
                   
                 0.022395 
                 1.10 
                 2094 
                   
                   
                   
                 T 
               
               
                 All groups 
                   
                   
                   
                 0.000145 
                 1.12 
                 3559 
                   
                   
                   
                 T 
               
               
                 SG07S302 
                   
                 C07 
                 116579323 
               
               
                 Iceland discovery group 
                 rs1029396 
                   
                   
                 0.001065 
                 1.28 
                 1634 
                 0.089 
                 6867 
                 0.071 
                 G 
               
               
                 Iceland replication group 
                 rs1029396 
                   
                   
                 0.719800 
                 0.95 
                 548 
                 0.063 
                 3393 
                 0.066 
                 G 
               
               
                 Iceland All 
                 rs1029396 
                   
                   
                 0.003796 
                 1.21 
                 2182 
                 0.082 
                 10260 
                 0.069 
                 G 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                 rs1029396 
                   
                   
                 0.391029 
                 1.15 
                 363 
                 0.094 
                 572 
                 0.082 
                 G 
               
               
                 Durham 
                 rs1029396 
                   
                   
                 0.053907 
                 1.25 
                 1212 
                 0.101 
                 735 
                 0.083 
                 G 
               
               
                 All US groups 
                   
                   
                   
                 0.038030 
                 1.22 
                 1575 
                   
                   
                   
                 G 
               
               
                 All replication groups 
                   
                   
                   
                 0.138284 
                 1.12 
                 2107 
                   
                   
                   
                 G 
               
               
                 All groups 
                   
                   
                   
                 0.000370 
                 1.21 
                 3573 
                   
                   
                   
                 G 
               
               
                 SG08S1314 
                   
                 C08 
                 18899082 
               
               
                 Iceland discovery group 
                 rs334198 
                   
                   
                 0.020830 
                 1.19 
                 1630 
                 0.090 
                 6865 
                 0.076 
                 A 
               
               
                 Iceland replication group 
                 rs334198 
                   
                   
                 0.059380 
                 1.25 
                 549 
                 0.089 
                 3393 
                 0.073 
                 A 
               
               
                 Iceland All 
                 rs334198 
                   
                   
                 0.002535 
                 1.21 
                 2179 
                 0.089 
                 10258 
                 0.075 
                 A 
               
               
                 Philadelphia 
                 rs334198 
                   
                   
                 0.370833 
                 0.87 
                 543 
                 0.088 
                 475 
                 0.100 
                 A 
               
               
                 Atlanta 
                 rs334198 
                   
                   
                 0.778416 
                 1.05 
                 367 
                 0.086 
                 542 
                 0.082 
                 A 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 0.627319 
                 0.95 
                 910 
                   
                   
                   
                 A 
               
               
                 All replication groups 
                   
                   
                   
                 0.348780 
                 1.08 
                 1443 
                   
                   
                   
                 A 
               
               
                 All groups 
                   
                   
                   
                 0.016141 
                 1.14 
                 2905 
                   
                   
                   
                 A 
               
               
                 SG08S1315 
                   
                 C08 
                 28215758 
               
               
                 Iceland discovery group 
                 rs4732849 
                   
                   
                 0.000349 
                 1.18 
                 1641 
                 0.306 
                 6868 
                 0.273 
                 T 
               
               
                 Iceland replication group 
                 rs4732849 
                   
                   
                 0.077900 
                 1.14 
                 550 
                 0.298 
                 3393 
                 0.272 
                 T 
               
               
                 Iceland All 
                 rs4732849 
                   
                   
                 0.000056 
                 1.17 
                 2191 
                 0.304 
                 10261 
                 0.273 
                 T 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                   
                   
                   
                 NA 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 NA 
                 NA 
                 NA 
               
               
                 All replication groups 
                   
                   
                   
                 0.077897 
                 1.14 
                 534 
                   
                   
                   
                 T 
               
               
                 All groups 
                   
                   
                   
                 0.000056 
                 1.17 
                 2006 
                   
                   
                   
                 T 
               
               
                 SG08S1325 
                   
                 C08 
                 129065286 
               
               
                 Iceland discovery group 
                 rs2302793 
                   
                   
                 0.002452 
                 1.14 
                 1614 
                 0.462 
                 6846 
                 0.431 
                 G 
               
               
                 Iceland replication group 
                 rs2302793 
                   
                   
                 0.601500 
                 1.09 
                 87 
                 0.454 
                 3370 
                 0.434 
                 G 
               
               
                 Iceland All 
                 rs2302793 
                   
                   
                 0.001920 
                 1.13 
                 1701 
                 0.461 
                 10216 
                 0.432 
                 G 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                   
                   
                   
                 NA 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 NA 
                 NA 
                 NA 
               
               
                 All replication groups 
                   
                   
                   
                 0.601476 
                 1.09 
                 84 
                   
                   
                   
                 G 
               
               
                 All groups 
                   
                   
                   
                 0.001920 
                 1.13 
                 1557 
                   
                   
                   
                 G 
               
               
                 SG08S1326 
                   
                 C08 
                 129067370 
               
               
                 Iceland discovery group 
                 rs3931282 
                   
                   
                 0.001650 
                 1.14 
                 1634 
                 0.461 
                 6868 
                 0.428 
                 C 
               
               
                 Iceland replication group 
                 rs3931282 
                   
                   
                 0.050490 
                 1.14 
                 547 
                 0.463 
                 3393 
                 0.431 
                 C 
               
               
                 Iceland All 
                 rs3931282 
                   
                   
                 0.000216 
                 1.14 
                 2181 
                 0.461 
                 10261 
                 0.429 
                 C 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                 rs3931282 
                   
                   
                 0.205449 
                 0.89 
                 362 
                 0.438 
                 587 
                 0.468 
                 C 
               
               
                 Durham 
                 rs3931282 
                   
                   
                 0.208270 
                 0.92 
                 1196 
                 0.455 
                 732 
                 0.476 
                 C 
               
               
                 All US groups 
                   
                   
                   
                 0.078904 
                 0.91 
                 1558 
                   
                   
                   
                 C 
               
               
                 All replication groups 
                   
                   
                   
                 0.904130 
                 0.99 
                 2089 
                   
                   
                   
                 C 
               
               
                 All groups 
                   
                   
                   
                 0.030734 
                 1.07 
                 3555 
                   
                   
                   
                 C 
               
               
                 SG10S822 
                   
                 C10 
                 45239070 
               
               
                 Iceland discovery group 
                 rs2279434 
                   
                   
                 0.000031 
                 1.38 
                 1634 
                 0.088 
                 6868 
                 0.065 
                 T 
               
               
                 Iceland replication group 
                 rs2279434 
                   
                   
                 0.509900 
                 1.09 
                 544 
                 0.071 
                 3392 
                 0.065 
                 T 
               
               
                 Iceland All 
                 rs2279434 
                   
                   
                 0.000053 
                 1.31 
                 2178 
                 0.083 
                 10260 
                 0.065 
                 T 
               
               
                 Philadelphia 
                 rs2279434 
                   
                   
                   
                 0.81 
                 532 
                 0.081 
                 472 
                 0.097 
                 T 
               
               
                 Atlanta 
                 rs2279434 
                   
                   
                   
                 0.83 
                 362 
                 0.070 
                 513 
                 0.084 
                 T 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 0.096180 
                 0.82 
                 894 
                   
                   
                   
                 T 
               
               
                 All replication groups 
                   
                   
                   
                 0.422694 
                 0.93 
                 1422 
                   
                   
                   
                 T 
               
               
                 All groups 
                   
                   
                   
                 0.006627 
                 1.17 
                 2888 
                   
                   
                   
                 T 
               
               
                 SG10S314 
                   
                 C10 
                 90667504 
               
               
                 Iceland discovery group 
                 rs1412444 
                   
                   
                 0.000082 
                 1.18 
                 1644 
                 0.396 
                 6861 
                 0.357 
                 A 
               
               
                 Iceland replication group 
                 rs1412444 
                   
                   
                 0.312500 
                 1.07 
                 582 
                 0.374 
                 3389 
                 0.358 
                 A 
               
               
                 Iceland All 
                 rs1412444 
                   
                   
                 0.000076 
                 1.15 
                 2226 
                 0.390 
                 10250 
                 0.357 
                 A 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                 rs1412444 
                   
                   
                 0.314043 
                 1.11 
                 367 
                 0.356 
                 581 
                 0.333 
                 A 
               
               
                 Durham 
                 rs1412444 
                   
                   
                 0.913736 
                 1.02 
                 257 
                 0.368 
                 121 
                 0.364 
                 A 
               
               
                 All US groups 
                   
                   
                   
                 0.360084 
                 1.08 
                 624 
                   
                   
                   
                 A 
               
               
                 All replication groups 
                   
                   
                   
                 0.173888 
                 1.07 
                 1189 
                   
                   
                   
                 A 
               
               
                 All groups 
                   
                   
                   
                 0.000063 
                 1.14 
                 2662 
                   
                   
                   
                 A 
               
               
                 SG12S844 
                   
                 C12 
                 21092930 
               
               
                 Iceland discovery group 
                 rs11045689 
                   
                   
                 0.011540 
                 1.12 
                 1630 
                 0.321 
                 6854 
                 0.297 
                 G 
               
               
                 Iceland replication group 
                 rs11045689 
                   
                   
                 0.133900 
                 1.11 
                 541 
                 0.318 
                 3386 
                 0.295 
                 G 
               
               
                 Iceland All 
                 rs11045689 
                   
                   
                 0.002878 
                 1.12 
                 2171 
                 0.320 
                 10240 
                 0.296 
                 G 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                   
                   
                   
                 NA 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 NA 
                 NA 
                 NA 
               
               
                 All replication groups 
                   
                   
                   
                 0.133868 
                 1.11 
                 526 
                   
                   
                   
                 G 
               
               
                 All groups 
                   
                   
                   
                 0.002878 
                 1.12 
                 1988 
                   
                   
                   
                 G 
               
               
                 SG14S801 
                   
                 C14 
                 67308303 
               
               
                 Iceland discovery group 
                 rs8003722 
                   
                   
                 0.000343 
                 1.26 
                 1642 
                 0.127 
                 6867 
                 0.104 
                 A 
               
               
                 Iceland replication group 
                 rs8003722 
                   
                   
                 0.007542 
                 1.32 
                 561 
                 0.125 
                 3393 
                 0.098 
                 A 
               
               
                 Iceland All 
                 rs8003722 
                   
                   
                 0.000006 
                 1.28 
                 2203 
                 0.126 
                 10260 
                 0.102 
                 A 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                 rs8003722 
                   
                   
                 0.734831 
                 1.04 
                 472 
                 0.151 
                 1029 
                 0.147 
                 A 
               
               
                 Durham 
                 rs8003722 
                   
                   
                 0.431112 
                 0.93 
                 1202 
                 0.135 
                 735 
                 0.144 
                 A 
               
               
                 All US groups 
                   
                   
                   
                 0.708199 
                 0.97 
                 1674 
               
               
                 All replication groups 
                   
                   
                   
                 0.225792 
                 1.08 
                 2219 
                   
                   
                   
                 A 
               
               
                 All groups 
                   
                   
                   
                 0.000670 
                 1.16 
                 3691 
                   
                   
                   
                 A 
               
               
                 SG14S796 
                   
                 C14 
                 98131730 
               
               
                 Iceland discovery group 
                 rs7158073 
                   
                   
                 0.000697 
                 1.15 
                 1630 
                 0.461 
                 6835 
                 0.426 
                 T 
               
               
                 Iceland replication group 
                 rs7158073 
                   
                   
                 0.017800 
                 1.17 
                 546 
                 0.477 
                 3384 
                 0.438 
                 T 
               
               
                 Iceland All 
                 rs7158073 
                   
                   
                 0.000055 
                 1.15 
                 2176 
                 0.465 
                 10219 
                 0.430 
                 T 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                 rs7158073 
                   
                   
                 0.647425 
                 1.05 
                 362 
                 0.419 
                 575 
                 0.408 
                 T 
               
               
                 Durham 
                 rs7158073 
                   
                   
                 0.059831 
                 1.14 
                 1174 
                 0.460 
                 719 
                 0.429 
                 T 
               
               
                 All US groups 
                   
                   
                   
                 0.071211 
                 1.10 
                 1536 
                   
                   
                   
                 T 
               
               
                 All replication groups 
                   
                   
                   
                 0.003703 
                 1.13 
                 2066 
                   
                   
                   
                 T 
               
               
                 All groups 
                   
                   
                   
                 0.000012 
                 1.14 
                 3528 
                   
                   
                   
                 T 
               
               
                 SG14S794_SG14S795* 
                   
                 C14 
                 52400957 
               
               
                 Iceland discovery group 
                 rs4444235 
                 rs1957860 
                   
                 0.000323 
                 0.84 
                 1642 
                 0.290 
                 6868 
                 0.326 
                 C 
               
               
                 Iceland replication group 
                 rs4444235 
                 rs1957860 
                   
                 0.015250 
                 0.83 
                 561 
                 0.279 
                 3393 
                 0.317 
                 C 
               
               
                 Iceland All 
                 rs4444235 
                 rs1957860 
                   
                 0.000020 
                 0.84 
                 2203 
                 0.287 
                 10261 
                 0.323 
                 C 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                   
                   
                   
                 NA 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 NA 
                 NA 
                 NA 
               
               
                 All replication groups 
                 rs4444235 
                 rs1957860 
                   
                 0.015245 
                 0.83 
                 545 
                   
                   
                   
                 C 
               
               
                 All groups 
                 rs4444235 
                 rs1957860 
                   
                 0.000020 
                 0.84 
                 2017 
                   
                   
                   
                 C 
               
               
                 SG15S142 
                   
                 C15 
                 24926452 
               
               
                 Iceland discovery group 
                 rs2110209 
                   
                   
                 0.001794 
                 1.32 
                 1634 
                 0.063 
                 6868 
                 0.049 
                 A 
               
               
                 Iceland replication group 
                 rs2110209 
                   
                   
                 0.036840 
                 1.36 
                 545 
                 0.059 
                 3393 
                 0.044 
                 A 
               
               
                 Iceland All 
                 rs2110209 
                   
                   
                 0.000106 
                 1.34 
                 2179 
                 0.062 
                 10261 
                 0.047 
                 A 
               
               
                 Philadelphia 
                   
                   
                   
                 NA 
               
               
                 Atlanta 
                   
                   
                   
                 NA 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 NA 
                 NA 
                 NA 
               
               
                 All replication groups 
                   
                   
                   
                 0.036835 
                 1.36 
                 529 
                   
                   
                   
                 A 
               
               
                 All groups 
                   
                   
                   
                 0.000105 
                 1.34 
                 1995 
                   
                   
                   
                 A 
               
               
                 SG17S742 
                   
                 C17 
                 17934326 
               
               
                 Iceland discovery group 
                 rs9902941 
                   
                   
                 0.000041 
                 1.19 
                 1642 
                 0.388 
                 6867 
                 0.348 
                 C 
               
               
                 Iceland replication group 
                 rs9902941 
                   
                   
                 0.961500 
                 1.00 
                 565 
                 0.351 
                 3393 
                 0.351 
                 C 
               
               
                 Iceland All 
                 rs9902941 
                   
                   
                 0.000278 
                 1.14 
                 2207 
                 0.379 
                 10260 
                 0.349 
                 C 
               
               
                 Philadelphia 
                 rs9902941 
                   
                   
                 0.170324 
                 1.13 
                 542 
                 0.423 
                 474 
                 0.393 
                 C 
               
               
                 Atlanta 
                 rs9902941 
                   
                   
                 0.246078 
                 1.09 
                 591 
                 0.372 
                 1210 
                 0.352 
                 C 
               
               
                 Durham 
                 rs9902941 
                   
                   
                 0.163124 
                 1.10 
                 1165 
                 0.378 
                 736 
                 0.355 
                 C 
               
               
                 All US groups 
                   
                   
                   
                 0.024495 
                 1.10 
                 2298 
                   
                   
                   
                 C 
               
               
                 All replication groups 
                   
                   
                   
                 0.055496 
                 1.07 
                 2847 
                   
                   
                   
                 C 
               
               
                 All groups 
                   
                   
                   
                 0.000023 
                 1.13 
                 4319 
                   
                   
                   
                 C 
               
               
                 SG17S743 
                   
                 C17 
                 17943470 
               
               
                 Iceland discovery group 
                 rs4925119 
                   
                   
                 0.000093 
                 1.18 
                 1630 
                 0.384 
                 6857 
                 0.345 
                 A 
               
               
                 Iceland replication group 
                 rs4925119 
                   
                   
                 0.975100 
                 1.00 
                 541 
                 0.349 
                 3384 
                 0.349 
                 A 
               
               
                 Iceland All 
                 rs4925119 
                   
                   
                 0.000529 
                 1.13 
                 2171 
                 0.375 
                 10241 
                 0.346 
                 A 
               
               
                 Philadelphia 
                 rs4925119 
                   
                   
                 0.312163 
                 1.10 
                 537 
                 0.419 
                 470 
                 0.397 
                 A 
               
               
                 Atlanta 
                 rs4925119 
                   
                   
                 0.155471 
                 1.11 
                 646 
                 0.372 
                 1207 
                 0.349 
                 A 
               
               
                 Durham 
                 rs4925119 
                   
                   
                 0.139467 
                 1.11 
                 1189 
                 0.373 
                 729 
                 0.350 
                 A 
               
               
                 All US groups 
                   
                   
                   
                 0.022416 
                 1.10 
                 2372 
                   
                   
                   
                 A 
               
               
                 All replication groups 
                   
                   
                   
                 0.051193 
                 1.07 
                 2898 
                   
                   
                   
                 A 
               
               
                 All groups 
                   
                   
                   
                 0.000037 
                 1.12 
                 4360 
                   
                   
                   
                 A 
               
               
                 SG17S744 
                   
                 C17 
                 17947855 
               
               
                 Iceland discovery group 
                 rs3183702 
                   
                   
                 0.000036 
                 1.19 
                 1633 
                 0.389 
                 6866 
                 0.348 
                 T 
               
               
                 Iceland replication group 
                 rs3183702 
                   
                   
                 0.970600 
                 1.00 
                 546 
                 0.352 
                 3391 
                 0.351 
                 T 
               
               
                 Iceland All 
                 rs3183702 
                   
                   
                 0.000241 
                 1.14 
                 2179 
                 0.380 
                 10257 
                 0.349 
                 T 
               
               
                 Philadelphia 
                 rs3183702 
                   
                   
                 0.132368 
                 1.15 
                 531 
                 0.427 
                 469 
                 0.393 
                 T 
               
               
                 Atlanta 
                 rs3183702 
                   
                   
                 0.018991 
                 1.26 
                 362 
                 0.391 
                 539 
                 0.337 
                 T 
               
               
                 Durham 
                 rs3183702 
                   
                   
                 0.469038 
                 1.06 
                 939 
                 0.368 
                 572 
                 0.355 
                 T 
               
               
                 All US groups 
                   
                   
                   
                 0.011987 
                 1.14 
                 1832 
                   
                   
                   
                 T 
               
               
                 All replication groups 
                   
                   
                   
                 0.041110 
                 1.09 
                 2362 
                   
                   
                   
                 T 
               
               
                 All groups 
                   
                   
                   
                 0.000009 
                 1.14 
                 3827 
                   
                   
                   
                 T 
               
               
                 SG17S746 
                   
                 C17 
                 18035257 
               
               
                 Iceland discovery group 
                 rs6502622 
                   
                   
                 0.000128 
                 1.18 
                 1641 
                 0.397 
                 6868 
                 0.359 
                 G 
               
               
                 Iceland replication group 
                 rs6502622 
                   
                   
                 0.699700 
                 1.03 
                 560 
                 0.366 
                 3393 
                 0.360 
                 G 
               
               
                 Iceland All 
                 rs6502622 
                   
                   
                 0.000347 
                 1.14 
                 2201 
                 0.389 
                 10261 
                 0.359 
                 G 
               
               
                 Philadelphia 
                 rs6502622 
                   
                   
                 0.277357 
                 1.10 
                 540 
                 0.433 
                 475 
                 0.409 
                 G 
               
               
                 Atlanta 
                 rs6502622 
                   
                   
                 0.041642 
                 1.16 
                 593 
                 0.401 
                 1227 
                 0.366 
                 G 
               
               
                 Durham 
                 rs6502622 
                   
                   
                 0.180470 
                 1.10 
                 1165 
                 0.399 
                 734 
                 0.377 
                 G 
               
               
                 All US groups 
                   
                   
                   
                 0.009300 
                 1.12 
                 2298 
                   
                   
                   
                 G 
               
               
                 All replication groups 
                   
                   
                   
                 0.016554 
                 1.09 
                 2842 
                   
                   
                   
                 G 
               
               
                 All groups 
                   
                   
                   
                 0.000010 
                 1.13 
                 4313 
                   
                   
                   
                 G 
               
               
                 SG17S750 
                   
                 C17 
                 18149041 
               
               
                 Iceland discovery group 
                 rs2955355 
                   
                   
                 0.000393 
                 1.17 
                 1634 
                 0.319 
                 6868 
                 0.285 
                 C 
               
               
                 Iceland replication group 
                 rs2955355 
                   
                   
                 0.393900 
                 1.06 
                 547 
                 0.303 
                 3393 
                 0.290 
                 C 
               
               
                 Iceland All 
                 rs2955355 
                   
                   
                 0.000440 
                 1.14 
                 2181 
                 0.315 
                 10261 
                 0.287 
                 C 
               
               
                 Philadelphia 
                 rs2955355 
                   
                   
                 0.630066 
                 1.05 
                 544 
                 0.362 
                 476 
                 0.352 
                 C 
               
               
                 Atlanta 
                 rs2955355 
                   
                   
                 0.002362 
                 1.37 
                 360 
                 0.360 
                 534 
                 0.291 
                 C 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 0.016778 
                 1.18 
                 904 
                   
                   
                   
                 C 
               
               
                 All replication groups 
                   
                   
                   
                 0.020472 
                 1.12 
                 1435 
                   
                   
                   
                 C 
               
               
                 All groups 
                   
                   
                   
                 0.000023 
                 1.15 
                 2901 
                   
                   
                   
                 C 
               
               
                 SG17S747 
                   
                 C17 
                 18204411 
               
               
                 Iceland discovery group 
                 rs854813 
                   
                   
                 0.000154 
                 1.17 
                 1634 
                 0.425 
                 6865 
                 0.387 
                 C 
               
               
                 Iceland replication group 
                 rs854813 
                   
                   
                 0.964800 
                 1.00 
                 543 
                 0.386 
                 3393 
                 0.387 
                 C 
               
               
                 Iceland All 
                 rs854813 
                   
                   
                 0.000785 
                 1.13 
                 2177 
                 0.415 
                 10258 
                 0.387 
                 C 
               
               
                 Philadelphia 
                 rs854813 
                   
                   
                 0.077440 
                 1.17 
                 520 
                 0.468 
                 462 
                 0.429 
                 C 
               
               
                 Atlanta 
                 rs854813 
                   
                   
                 0.009373 
                 1.29 
                 364 
                 0.449 
                 539 
                 0.388 
                 C 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 0.002182 
                 1.23 
                 884 
                   
                   
                   
                 C 
               
               
                 All replication groups 
                   
                   
                   
                 0.030822 
                 1.11 
                 1411 
                   
                   
                   
                 C 
               
               
                 All groups 
                   
                   
                   
                 0.000011 
                 1.15 
                 2877 
                   
                   
                   
                 C 
               
               
                 SG17S749 
                   
                 C17 
                 18231090 
               
               
                 Iceland discovery group 
                 rs854793 
                   
                   
                 0.000495 
                 1.19 
                 1634 
                 0.231 
                 6865 
                 0.201 
                 A 
               
               
                 Iceland replication group 
                 rs854793 
                   
                   
                 0.576100 
                 0.95 
                 491 
                 0.198 
                 3392 
                 0.205 
                 A 
               
               
                 Iceland All 
                 rs854793 
                   
                   
                 0.004364 
                 1.13 
                 2125 
                 0.223 
                 10257 
                 0.203 
                 A 
               
               
                 Philadelphia 
                 rs854793 
                   
                   
                 0.456629 
                 1.08 
                 505 
                 0.260 
                 454 
                 0.246 
                 A 
               
               
                 Atlanta 
                 rs854793 
                   
                   
                 0.040285 
                 1.26 
                 369 
                 0.255 
                 539 
                 0.213 
                 A 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 0.052002 
                 1.16 
                 874 
                   
                   
                   
                 A 
               
               
                 All replication groups 
                   
                   
                   
                 0.283691 
                 1.06 
                 1351 
                   
                   
                   
                 A 
               
               
                 All groups 
                   
                   
                   
                 0.000591 
                 1.14 
                 2820 
                   
                   
                   
                 A 
               
               
                 SG17S748 
                   
                 C17 
                 18235585 
               
               
                 Iceland discovery group 
                 rs854787 
                   
                   
                 0.000005 
                 1.21 
                 1635 
                 0.444 
                 6816 
                 0.398 
                 C 
               
               
                 Iceland replication group 
                 rs854787 
                   
                   
                 0.580200 
                 0.96 
                 565 
                 0.390 
                 3379 
                 0.399 
                 C 
               
               
                 Iceland all 
                 rs854787 
                   
                   
                 0.000171 
                 1.14 
                 2200 
                 0.430 
                 10195 
                 0.398 
                 C 
               
               
                 Philadelphia 
                 rs854787 
                   
                   
                 0.241799 
                 1.11 
                 542 
                 0.458 
                 475 
                 0.433 
                 C 
               
               
                 Atlanta 
                 rs854787 
                   
                   
                 0.001746 
                 1.36 
                 360 
                 0.475 
                 507 
                 0.399 
                 C 
               
               
                 Durham 
                   
                   
                   
                 NA 
               
               
                 All US groups 
                   
                   
                   
                 0.002955 
                 1.22 
                 902 
                   
                   
                   
                 C 
               
               
                 All replication groups 
                   
                   
                   
                 0.085873 
                 1.08 
                 1451 
                   
                   
                   
                 C 
               
               
                 All groups 
                   
                   
                   
                 0.000002 
                 1.16 
                 2916 
                   
                   
                   
                 C 
               
               
                   
               
               
                 *2-marker haplotype consisting of markers SG14S794 and SG14S795 
               
            
           
         
       
     
     Example 2 
     Further genome-wide genotyping of Icelandic patients diagnosed with coronary artery disease and/or myocardial infarction was performed. Recruitment and phenotyping was described above under Example, and all methods involved were as described in the above. 
     Descriptions of the additional replication cohorts are as follows: 
     Cohort from Italy: The subjects from Verona were enrolled into the Verona Heart Project, which is an ongoing study aimed at identifying new risk factors for coronary artery disease (CAD) and myocardial infarction (MI) in a population of subjects with angiographic documentation of their coronary vessels. In brief, the CAD group had angiographically documented severe coronary atherosclerosis, the majority of them being candidates for coronary artery bypass grafting or percutaneous coronary intervention. Control subjects were selected such that they had normal coronary arteries, being submitted to coronary angiography for reasons other than CAD. Controls with history or clinical evidence of atherosclerosis in vascular districts beyond the coronary bed were excluded. Information on MI diagnoses was gathered through medical records showing diagnostic electrocardiogram and enzyme changes, and/or the typical sequelae of MI on ventricular angiography. The study was approved by local Ethical Committee. Informed consent was obtained from all the patients after a full explanation of the study. 
     Cohort from Johns Hopkins: The study group from Baltimore is comprised of The Johns Hopkins University Sibling and Family Heart Study, G-Cal, and GeneSTAR studies. The subjects consisted of families identified from 1983-2006 from probands with premature coronary disease event (before 60 years of age). Probands with documented CAD were identified at the time of hospitalization in any of the Baltimore area hospitals. Their apparently healthy siblings without CAD were recruited as well as adult offspring and spouses. Of probands, generally 24% had an MI as their index event, 65% had a PCI and/or CABG, 8.4% had angina with angiography documented CAD and were treated medically, 1.7% had sudden cardiac death, and 1.7% had angiographic documented coronary stenosis with an abnormal stress test and no symptoms. 
     Cohort from WTCCC: This study cohort has been described previously (Nature 447:661-78 (2007)). Summary statistics from a genome-wide association study performed on these samples is publicly available at http://www.wtccc.org.uk/info/summary_stats.shtml. 
     Reanalysis of the markers presented in Table 1 was performed using the expanded dataset of 3,047 individuals diagnosed with coronary artery disease, 2,395 diagnosed with myocardial infarction, and 28,321 population controls. The results are presented in Table 3. 
     The top 100 markers in the scan were explored further by replication analysis in six cohorts from Durham (N.C., US), Philadelphia (Pa., US), Atlanta (Ga., US), John Hopkins University (Maryland, US), Italy, and in a dataset from the Wellcom Trust Case Control Consortium (WTCCC; England). The replication cohorts combined comprise 6,108 cases and 19,396 controls. The results of the replication analysis is shown in Table 4A-4H, both separately for each cohort and a combined analysis for all the replication cohorts, as well as a combined for all the cohorts, including the Icelandic discovery cohort. Many of the variants discovered in the Icelandic discovery cohort show overall significant association in the combined replication groups. The effects are modest, which explains why some cohorts do not indicate significant association, while other cohorts do so. 
     In the combined analysis of all the groups (9,155 cases; 47,717 controls; Table 4H), marker rs11751605 stands out as the most significant, with a combined P-value of 1.16×10 −8 . This is a highly significant number, and in fact represents statistical significance at the genome-wide level, after applying the conservative Bonferroni correction for the number of statistical tests performed (approx. 300,000 in the combined analysis). It should be noted that the number of tests performed in the replication effort is much smaller; consequently, the correction to be applied to correct for the number of tests is smaller, or 100 (giving P-values of 0.05/100, or about 0.0005 as significant after correction). Several markers meet this threshold of significance. 
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 Association results for SNPs showing association to myoardial infarction (MI) and coronary artery 
               
               
                 disease (CAD). The results are based on a genomic scan using 2,395 MI samples, 3,047 CAD 
               
               
                 samples, and 28,321 controls. The columns indicate (1) chromosome, (2) position in NCBI Build 
               
               
                 36, (3) the associating allele (4), rs name of the SNP, (5) frequency of the associating allele in 
               
               
                 controls, (6) the number of controls, (7), the p-value for association to MI, (8) the Relative Risk 
               
               
                 of association to MI, (9) the frequency of the associating allele in MI patients, (10) the number 
               
               
                 of MI patients, (11) the p-value of association to CAD, (12) the Relative Risk of association to CAD, 
               
               
                 (13) the frequency of the associating allele in CAD patients, (14) the number of CAD patients. 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                 Pos in 
                   
                   
                   
                   
                   
                   
                   
                   
                 RR 
                 f 
                 N 
               
               
                 Chr 
                 SNP 
                 Build 36 
                 Allele 
                 f (con) 
                 N (con) 
                 P (MI) 
                 RR (MI) 
                 f (MI) 
                 N (MI) 
                 P (CAD) 
                 (CAD) 
                 (CAD) 
                 (CAD) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 C01 
                 rs10462018 
                 7802214 
                 C 
                 0.821 
                 28185 
                 1.40E−02 
                 1.11 
                 0.836 
                 2390 
                 1.20E−01 
                 1.06 
                 0.830 
                 3040 
               
               
                 C01 
                 rs2946534 
                 18647370 
                 T 
                 0.571 
                 28302 
                 3.40E−04 
                 1.13 
                 0.599 
                 2394 
                 4.50E−04 
                 1.11 
                 0.596 
                 3046 
               
               
                 C01 
                 rs3748744 
                 19828833 
                 G 
                 0.898 
                 28280 
                 6.30E−02 
                 1.11 
                 0.907 
                 2394 
                 3.30E−02 
                 1.11 
                 0.908 
                 3046 
               
               
                 C01 
                 rs7523192 
                 19835634 
                 T 
                 0.813 
                 28296 
                 7.10E−02 
                 1.08 
                 0.824 
                 2395 
                 1.50E−01 
                 1.06 
                 0.821 
                 3047 
               
               
                 C01 
                 rs7535952 
                 19846151 
                 A 
                 0.722 
                 28166 
                 6.60E−02 
                 1.07 
                 0.735 
                 2355 
                 6.40E−02 
                 1.06 
                 0.734 
                 3003 
               
               
                 C01 
                 rs2072671 
                 20788288 
                 C 
                 0.313 
                 28310 
                 0.0011 
                 1.12 
                 0.338 
                 2395 
                 1.30E−03 
                 1.11 
                 0.335 
                 3047 
               
               
                 C01 
                 rs12724604 
                 20948045 
                 A 
                 0.037 
                 28248 
                 9.80E−03 
                 1.23 
                 0.045 
                 2386 
                 2.10E−02 
                 1.19 
                 0.043 
                 3037 
               
               
                 C01 
                 rs12741305 
                 21192774 
                 C 
                 0.038 
                 28320 
                 0.0087 
                 1.23 
                 0.046 
                 2393 
                 2.30E−02 
                 1.18 
                 0.044 
                 3044 
               
               
                 C01 
                 rs10799128 
                 29476586 
                 T 
                 0.200 
                 28211 
                 0.062 
                 1.08 
                 0.212 
                 2378 
                 1.40E−01 
                 1.06 
                 0.208 
                 3029 
               
               
                 C01 
                 rs1932397 
                 29835784 
                 G 
                 0.822 
                 28320 
                 1.80E−03 
                 1.15 
                 0.841 
                 2395 
                 2.80E−03 
                 1.13 
                 0.839 
                 3047 
               
               
                 C01 
                 rs407838 
                 30585414 
                 C 
                 0.846 
                 28311 
                 0.0039 
                 1.14 
                 0.863 
                 2395 
                 4.70E−03 
                 1.13 
                 0.861 
                 3047 
               
               
                 C01 
                 rs593993 
                 30648371 
                 C 
                 0.838 
                 28311 
                 0.00099 
                 1.16 
                 0.858 
                 2392 
                 9.30E−04 
                 1.15 
                 0.856 
                 3044 
               
               
                 C01 
                 rs12029866 
                 30657936 
                 G 
                 0.775 
                 28318 
                 0.0043 
                 1.12 
                 0.794 
                 2395 
                 4.40E−03 
                 1.11 
                 0.792 
                 3047 
               
               
                 C01 
                 rs12126748 
                 31307750 
                 A 
                 0.346 
                 27660 
                 0.0018 
                 1.11 
                 0.371 
                 2341 
                 9.90E−03 
                 1.08 
                 0.365 
                 2979 
               
               
                 C01 
                 rs661221 
                 40866417 
                 G 
                 0.805 
                 28299 
                 1.80E−02 
                 1.10 
                 0.820 
                 2392 
                 2.40E−01 
                 1.05 
                 0.811 
                 3044 
               
               
                 C01 
                 rs7524868 
                 40879361 
                 G 
                 0.306 
                 28288 
                 1.80E−02 
                 1.09 
                 0.324 
                 2385 
                 1.20E−01 
                 1.05 
                 0.316 
                 3036 
               
               
                 C01 
                 rs7520394 
                 40882456 
                 T 
                 0.649 
                 28231 
                 0.0014 
                 1.12 
                 0.674 
                 2390 
                 7.50E−02 
                 1.06 
                 0.662 
                 3041 
               
               
                 C01 
                 rs2294512 
                 54142894 
                 G 
                 0.688 
                 28321 
                 0.064 
                 1.07 
                 0.702 
                 2395 
                 7.00E−02 
                 1.06 
                 0.701 
                 3047 
               
               
                 C01 
                 rs4927219 
                 55524409 
                 G 
                 0.603 
                 28319 
                 4.50E−03 
                 1.10 
                 0.625 
                 2395 
                 3.80E−03 
                 1.09 
                 0.624 
                 3047 
               
               
                 C01 
                 rs2991515 
                 57656898 
                 T 
                 0.483 
                 28319 
                 0.0033 
                 1.10 
                 0.507 
                 2395 
                 7.70E−04 
                 1.10 
                 0.508 
                 3047 
               
               
                 C01 
                 rs11208061 
                 63165253 
                 A 
                 0.346 
                 27897 
                 0.0014 
                 1.12 
                 0.371 
                 2375 
                 6.10E−03 
                 1.09 
                 0.365 
                 3012 
               
               
                 C01 
                 rs12134779 
                 63168930 
                 T 
                 0.292 
                 28320 
                 0.0000094 
                 1.17 
                 0.325 
                 2394 
                 2.80E−04 
                 1.12 
                 0.316 
                 3046 
               
               
                 C01 
                 rs6696619 
                 63225377 
                 C 
                 0.673 
                 28302 
                 6.70E−02 
                 1.07 
                 0.687 
                 2395 
                 3.20E−01 
                 1.03 
                 0.680 
                 3047 
               
               
                 C01 
                 rs1747924 
                 64311549 
                 T 
                 0.810 
                 28282 
                 0.019 
                 1.10 
                 0.825 
                 2395 
                 0.23 
                 1.05 
                 0.817 
                 3044 
               
               
                 C01 
                 rs2806535 
                 64350358 
                 A 
                 0.483 
                 28297 
                 0.013 
                 1.09 
                 0.504 
                 2394 
                 0.0066 
                 1.08 
                 0.503 
                 3043 
               
               
                 C01 
                 rs3818513 
                 65646625 
                 C 
                 0.462 
                 28320 
                 0.049 
                 1.07 
                 0.477 
                 2395 
                 0.38 
                 1.03 
                 0.468 
                 3047 
               
               
                 C01 
                 rs2025805 
                 65722466 
                 C 
                 0.567 
                 28315 
                 0.023 
                 1.08 
                 0.585 
                 2395 
                 0.015 
                 1.08 
                 0.584 
                 3047 
               
               
                 C01 
                 rs10489554 
                 69921136 
                 T 
                 0.776 
                 28311 
                 0.0089 
                 1.11 
                 0.793 
                 2395 
                 0.038 
                 1.08 
                 0.788 
                 3046 
               
               
                 C01 
                 rs10518531 
                 76871826 
                 C 
                 0.845 
                 28121 
                 0.032 
                 1.10 
                 0.858 
                 2359 
                 0.06 
                 1.08 
                 0.855 
                 3004 
               
               
                 C01 
                 rs1566250 
                 76986952 
                 G 
                 0.703 
                 28309 
                 0.00084 
                 1.13 
                 0.728 
                 2395 
                 0.0011 
                 1.11 
                 0.725 
                 3047 
               
               
                 C01 
                 rs1412414 
                 78711365 
                 G 
                 0.620 
                 28290 
                 2.40E−03 
                 1.11 
                 0.644 
                 2394 
                 0.00059 
                 1.11 
                 0.645 
                 3044 
               
               
                 C01 
                 rs1543675 
                 78719467 
                 C 
                 0.380 
                 28318 
                 0.0013 
                 1.11 
                 0.405 
                 2395 
                 0.0036 
                 1.09 
                 0.401 
                 3046 
               
               
                 C01 
                 rs1030414 
                 81241030 
                 G 
                 0.902 
                 28318 
                 0.039 
                 1.12 
                 0.912 
                 2395 
                 0.046 
                 1.11 
                 0.911 
                 3046 
               
               
                 C01 
                 rs7531507 
                 81261795 
                 G 
                 0.922 
                 28296 
                 0.039 
                 1.14 
                 0.930 
                 2394 
                 0.021 
                 1.14 
                 0.931 
                 3045 
               
               
                 C01 
                 rs12032817 
                 82949953 
                 G 
                 0.375 
                 28320 
                 4.30E−03 
                 1.10 
                 0.398 
                 2395 
                 0.0046 
                 1.09 
                 0.396 
                 3047 
               
               
                 C01 
                 rs1360903 
                 86345051 
                 G 
                 0.508 
                 28234 
                 0.0055 
                 1.09 
                 0.531 
                 2389 
                 0.006 
                 1.09 
                 0.529 
                 3040 
               
               
                 C01 
                 rs10801705 
                 89272970 
                 A 
                 0.462 
                 28318 
                 0.0074 
                 1.09 
                 0.483 
                 2394 
                 0.018 
                 1.07 
                 0.479 
                 3046 
               
               
                 C01 
                 rs4147861 
                 94244536 
                 G 
                 0.922 
                 28179 
                 0.0019 
                 1.22 
                 0.935 
                 2359 
                 0.0012 
                 1.21 
                 0.934 
                 3009 
               
               
                 C01 
                 rs10494048 
                 106996582 
                 T 
                 0.381 
                 28261 
                 0.00089 
                 1.12 
                 0.407 
                 2394 
                 0.014 
                 1.08 
                 0.399 
                 3044 
               
               
                 C01 
                 rs2335793 
                 107945406 
                 C 
                 0.890 
                 28309 
                 0.006 
                 1.16 
                 0.904 
                 2393 
                 0.014 
                 1.13 
                 0.901 
                 3045 
               
               
                 C01 
                 rs6688859 
                 113577284 
                 T 
                 0.683 
                 28320 
                 0.19 
                 1.05 
                 0.693 
                 2395 
                 0.11 
                 1.05 
                 0.694 
                 3047 
               
               
                 C01 
                 rs773586 
                 113643259 
                 A 
                 0.488 
                 28315 
                 0.015 
                 1.08 
                 0.508 
                 2395 
                 0.0096 
                 1.08 
                 0.507 
                 3047 
               
               
                 C01 
                 rs773588 
                 113646347 
                 C 
                 0.282 
                 28300 
                 0.11 
                 1.06 
                 0.293 
                 2394 
                 0.023 
                 1.08 
                 0.297 
                 3046 
               
               
                 C01 
                 rs2797409 
                 114131725 
                 C 
                 0.248 
                 28318 
                 0.0024 
                 1.12 
                 0.269 
                 2395 
                 0.0036 
                 1.10 
                 0.266 
                 3047 
               
               
                 C01 
                 rs2476601 
                 114179091 
                 A 
                 0.129 
                 28313 
                 0.000031 
                 1.21 
                 0.152 
                 2395 
                 0.000097 
                 1.18 
                 0.148 
                 3047 
               
               
                 C01 
                 rs1217407 
                 114195271 
                 A 
                 0.247 
                 28266 
                 2.10E−03 
                 1.12 
                 0.269 
                 2394 
                 0.0031 
                 1.10 
                 0.266 
                 3045 
               
               
                 C01 
                 rs1970568 
                 149842380 
                 T 
                 0.815 
                 28313 
                 0.001 
                 1.15 
                 0.835 
                 2395 
                 0.021 
                 1.09 
                 0.828 
                 3047 
               
               
                 C01 
                 rs6702842 
                 149874720 
                 G 
                 0.272 
                 28099 
                 0.0072 
                 1.10 
                 0.292 
                 2379 
                 0.072 
                 1.06 
                 0.284 
                 3029 
               
               
                 C01 
                 rs2495392 
                 149943873 
                 G 
                 0.278 
                 28312 
                 0.0038 
                 1.11 
                 0.299 
                 2395 
                 0.052 
                 1.07 
                 0.291 
                 3046 
               
               
                 C01 
                 rs12066445 
                 150007044 
                 A 
                 0.302 
                 28320 
                 5.90E−04 
                 1.13 
                 0.327 
                 2395 
                 0.0094 
                 1.09 
                 0.319 
                 3047 
               
               
                 C01 
                 rs9826 
                 150045523 
                 G 
                 0.329 
                 28106 
                 0.0021 
                 1.11 
                 0.353 
                 2377 
                 0.03 
                 1.07 
                 0.344 
                 3022 
               
               
                 C01 
                 rs949969 
                 150059438 
                 T 
                 0.199 
                 28317 
                 0.016 
                 1.10 
                 0.214 
                 2395 
                 0.039 
                 1.08 
                 0.211 
                 3047 
               
               
                 C01 
                 rs4845552 
                 151746622 
                 G 
                 0.128 
                 28269 
                 0.0025 
                 1.15 
                 0.145 
                 2393 
                 0.00041 
                 1.16 
                 0.146 
                 3044 
               
               
                 C01 
                 rs822519 
                 154107330 
                 A 
                 0.935 
                 28320 
                 0.024 
                 1.17 
                 0.944 
                 2395 
                 0.025 
                 1.15 
                 0.943 
                 3047 
               
               
                 C01 
                 rs12567958 
                 154861280 
                 C 
                 0.265 
                 28272 
                 0.024 
                 1.09 
                 0.282 
                 2392 
                 0.075 
                 1.06 
                 0.277 
                 3043 
               
               
                 C01 
                 rs4971177 
                 156256292 
                 T 
                 0.914 
                 28315 
                 5.20E−04 
                 1.24 
                 0.929 
                 2395 
                 0.0015 
                 1.19 
                 0.927 
                 3047 
               
               
                 C01 
                 rs2651860 
                 163647679 
                 T 
                 0.785 
                 28321 
                 0.011 
                 1.11 
                 0.801 
                 2395 
                 0.012 
                 1.10 
                 0.800 
                 3046 
               
               
                 C01 
                 rs11582943 
                 169209225 
                 A 
                 0.941 
                 28257 
                 0.0019 
                 1.26 
                 0.953 
                 2388 
                 0.00098 
                 1.25 
                 0.952 
                 3039 
               
               
                 C01 
                 rs12033847 
                 174294601 
                 T 
                 0.460 
                 27452 
                 0.011 
                 1.09 
                 0.481 
                 2360 
                 0.0029 
                 1.09 
                 0.482 
                 2999 
               
               
                 C01 
                 rs2175177 
                 174450679 
                 A 
                 0.461 
                 28011 
                 6.20E−03 
                 1.09 
                 0.483 
                 2386 
                 0.0016 
                 1.10 
                 0.484 
                 3030 
               
               
                 C01 
                 rs4651384 
                 185685027 
                 G 
                 0.687 
                 28319 
                 0.0025 
                 1.11 
                 0.709 
                 2395 
                 0.028 
                 1.07 
                 0.702 
                 3047 
               
               
                 C01 
                 rs2250227 
                 185696690 
                 C 
                 0.337 
                 28310 
                 0.0058 
                 1.10 
                 0.358 
                 2395 
                 0.021 
                 1.07 
                 0.353 
                 3047 
               
               
                 C01 
                 rs1339083 
                 185819288 
                 A 
                 0.345 
                 28315 
                 0.01 
                 1.09 
                 0.365 
                 2395 
                 0.0018 
                 1.10 
                 0.367 
                 3047 
               
               
                 C01 
                 rs2383658 
                 185847926 
                 G 
                 0.394 
                 28312 
                 0.022 
                 1.08 
                 0.412 
                 2395 
                 0.0057 
                 1.09 
                 0.414 
                 3047 
               
               
                 C01 
                 rs792446 
                 210623301 
                 G 
                 0.617 
                 28317 
                 0.016 
                 1.09 
                 0.636 
                 2395 
                 0.052 
                 1.06 
                 0.631 
                 3046 
               
               
                 C01 
                 rs11118175 
                 217155936 
                 G 
                 0.077 
                 28315 
                 0.026 
                 1.14 
                 0.087 
                 2395 
                 0.0077 
                 1.15 
                 0.087 
                 3047 
               
               
                 C01 
                 rs2642438 
                 219036651 
                 G 
                 0.712 
                 11355 
                 0.0079 
                 1.12 
                 0.735 
                 1767 
                 0.083 
                 1.07 
                 0.726 
                 2084 
               
               
                 C01 
                 rs1519463 
                 219944762 
                 G 
                 0.508 
                 28316 
                 0.0096 
                 1.09 
                 0.529 
                 2395 
                 0.0035 
                 1.09 
                 0.530 
                 3047 
               
               
                 C01 
                 rs1341449 
                 239642925 
                 A 
                 0.548 
                 28236 
                 0.0079 
                 1.09 
                 0.570 
                 2373 
                 0.0083 
                 1.08 
                 0.568 
                 3024 
               
               
                 C01 
                 rs3014559 
                 239649291 
                 A 
                 0.550 
                 28231 
                 0.022 
                 1.08 
                 0.569 
                 2393 
                 0.015 
                 1.08 
                 0.568 
                 3044 
               
               
                 C01 
                 rs12068067 
                 245092561 
                 G 
                 0.774 
                 28183 
                 0.0059 
                 1.12 
                 0.793 
                 2390 
                 0.0064 
                 1.10 
                 0.791 
                 3041 
               
               
                 C02 
                 rs7608117 
                 11183423 
                 T 
                 0.487 
                 28310 
                 0.0037 
                 1.10 
                 0.511 
                 2393 
                 0.028 
                 1.07 
                 0.503 
                 3044 
               
               
                 C02 
                 rs10929777 
                 12079564 
                 C 
                 0.305 
                 28316 
                 1.60E−01 
                 1.05 
                 0.315 
                 2395 
                 0.22 
                 1.04 
                 0.313 
                 3047 
               
               
                 C02 
                 rs11897395 
                 16671068 
                 C 
                 0.890 
                 28200 
                 0.0085 
                 1.15 
                 0.903 
                 2379 
                 0.028 
                 1.11 
                 0.900 
                 3028 
               
               
                 C02 
                 rs2342551 
                 17178028 
                 T 
                 0.713 
                 28317 
                 0.0023 
                 1.12 
                 0.735 
                 2395 
                 0.012 
                 1.09 
                 0.729 
                 3047 
               
               
                 C02 
                 rs12467812 
                 19858951 
                 G 
                 0.330 
                 28257 
                 0.035 
                 1.08 
                 0.346 
                 2395 
                 0.018 
                 1.08 
                 0.346 
                 3047 
               
               
                 C02 
                 rs10200481 
                 24191365 
                 A 
                 0.110 
                 28314 
                 0.018 
                 1.13 
                 0.122 
                 2395 
                 0.079 
                 1.09 
                 0.118 
                 3047 
               
               
                 C02 
                 rs6747236 
                 35901725 
                 T 
                 0.717 
                 28311 
                 0.0021 
                 1.12 
                 0.739 
                 2395 
                 0.0098 
                 1.09 
                 0.734 
                 3047 
               
               
                 C02 
                 rs10203034 
                 35916379 
                 A 
                 0.681 
                 28318 
                 0.0032 
                 1.11 
                 0.703 
                 2395 
                 0.018 
                 1.08 
                 0.697 
                 3047 
               
               
                 C02 
                 rs963731 
                 39070377 
                 C 
                 0.954 
                 27813 
                 0.0019 
                 1.30 
                 0.964 
                 2347 
                 0.001 
                 1.28 
                 0.963 
                 2991 
               
               
                 C02 
                 rs2168043 
                 39185597 
                 C 
                 0.867 
                 28278 
                 0.0077 
                 1.14 
                 0.881 
                 2395 
                 0.0042 
                 1.14 
                 0.881 
                 3047 
               
               
                 C02 
                 rs10202624 
                 42368892 
                 A 
                 0.095 
                 28319 
                 0.028 
                 1.13 
                 0.106 
                 2395 
                 0.04 
                 1.11 
                 0.104 
                 3047 
               
               
                 C02 
                 rs6724757 
                 42384655 
                 A 
                 0.092 
                 28315 
                 0.042 
                 1.12 
                 0.101 
                 2395 
                 0.057 
                 1.10 
                 0.100 
                 3047 
               
               
                 C02 
                 rs1991739 
                 43797029 
                 A 
                 0.618 
                 28313 
                 0.035 
                 1.07 
                 0.635 
                 2395 
                 0.081 
                 1.06 
                 0.631 
                 3047 
               
               
                 C02 
                 rs6709904 
                 43933828 
                 A 
                 0.909 
                 28315 
                 0.058 
                 1.12 
                 0.918 
                 2395 
                 0.014 
                 1.14 
                 0.919 
                 3046 
               
               
                 C02 
                 rs908571 
                 45171969 
                 C 
                 0.289 
                 28285 
                 0.00081 
                 1.13 
                 0.314 
                 2392 
                 0.0028 
                 1.10 
                 0.310 
                 3043 
               
               
                 C02 
                 rs3788982 
                 49098912 
                 G 
                 0.871 
                 28320 
                 0.0034 
                 1.16 
                 0.887 
                 2395 
                 0.0029 
                 1.15 
                 0.885 
                 3047 
               
               
                 C02 
                 rs6743414 
                 49277575 
                 G 
                 0.847 
                 28314 
                 0.0011 
                 1.16 
                 0.866 
                 2395 
                 0.0011 
                 1.15 
                 0.864 
                 3047 
               
               
                 C02 
                 rs4853116 
                 75264786 
                 A 
                 0.632 
                 28051 
                 0.066 
                 1.06 
                 0.646 
                 2390 
                 0.015 
                 1.08 
                 0.649 
                 3041 
               
               
                 C02 
                 rs317285 
                 76133652 
                 A 
                 0.499 
                 28318 
                 0.0026 
                 1.10 
                 0.524 
                 2395 
                 0.006 
                 1.09 
                 0.520 
                 3047 
               
               
                 C02 
                 rs404892 
                 76157421 
                 C 
                 0.500 
                 28297 
                 0.002 
                 1.11 
                 0.525 
                 2395 
                 0.0052 
                 1.09 
                 0.521 
                 3046 
               
               
                 C02 
                 rs443713 
                 76163892 
                 G 
                 0.392 
                 28316 
                 0.0011 
                 1.11 
                 0.418 
                 2395 
                 0.0011 
                 1.10 
                 0.415 
                 3047 
               
               
                 C02 
                 rs7563058 
                 76196590 
                 C 
                 0.499 
                 28313 
                 0.0018 
                 1.11 
                 0.524 
                 2395 
                 0.0045 
                 1.09 
                 0.520 
                 3047 
               
               
                 C02 
                 rs1595968 
                 76225824 
                 T 
                 0.393 
                 11401 
                 0.00037 
                 1.15 
                 0.427 
                 1770 
                 0.0009 
                 1.13 
                 0.423 
                 2089 
               
               
                 C02 
                 rs2861078 
                 77551503 
                 T 
                 0.579 
                 28249 
                 0.28 
                 1.04 
                 0.588 
                 2392 
                 0.18 
                 1.04 
                 0.589 
                 3042 
               
               
                 C02 
                 rs6547152 
                 77634997 
                 C 
                 0.790 
                 28305 
                 0.12 
                 1.07 
                 0.801 
                 2393 
                 0.1 
                 1.06 
                 0.800 
                 3044 
               
               
                 C02 
                 rs2861264 
                 78220585 
                 T 
                 0.107 
                 28303 
                 0.0057 
                 1.15 
                 0.121 
                 2394 
                 0.024 
                 1.11 
                 0.117 
                 3046 
               
               
                 C02 
                 rs11675205 
                 85323792 
                 A 
                 0.255 
                 28302 
                 0.0005 
                 1.14 
                 0.280 
                 2394 
                 0.0011 
                 1.11 
                 0.276 
                 3046 
               
               
                 C02 
                 rs2245113 
                 118108945 
                 A 
                 0.179 
                 28279 
                 0.017 
                 1.10 
                 0.194 
                 2392 
                 0.08 
                 1.07 
                 0.189 
                 3043 
               
               
                 C02 
                 rs1477451 
                 118164844 
                 T 
                 0.126 
                 28320 
                 0.0012 
                 1.17 
                 0.144 
                 2395 
                 0.0099 
                 1.12 
                 0.139 
                 3047 
               
               
                 C02 
                 rs1395930 
                 123468570 
                 T 
                 0.499 
                 28303 
                 3.20E−03 
                 1.10 
                 0.523 
                 2393 
                 0.00012 
                 1.12 
                 0.528 
                 3045 
               
               
                 C02 
                 rs2661006 
                 123482987 
                 T 
                 0.497 
                 28301 
                 0.0035 
                 1.10 
                 0.521 
                 2391 
                 0.00013 
                 1.12 
                 0.525 
                 3042 
               
               
                 C02 
                 rs3943703 
                 127613790 
                 C 
                 0.214 
                 28280 
                 0.02 
                 1.09 
                 0.229 
                 2395 
                 0.06 
                 1.07 
                 0.225 
                 3046 
               
               
                 C02 
                 rs4662743 
                 128067278 
                 T 
                 0.515 
                 28231 
                 0.042 
                 1.07 
                 0.531 
                 2392 
                 0.016 
                 1.07 
                 0.533 
                 3042 
               
               
                 C02 
                 rs2244871 
                 128115310 
                 C 
                 0.413 
                 28251 
                 0.013 
                 1.09 
                 0.433 
                 2394 
                 0.015 
                 1.08 
                 0.430 
                 3046 
               
               
                 C02 
                 rs2321299 
                 134350130 
                 C 
                 0.571 
                 28315 
                 0.034 
                 1.07 
                 0.588 
                 2395 
                 0.21 
                 1.04 
                 0.580 
                 3046 
               
               
                 C02 
                 rs2139311 
                 134628584 
                 C 
                 0.601 
                 28304 
                 0.0044 
                 1.10 
                 0.624 
                 2394 
                 0.0022 
                 1.10 
                 0.623 
                 3045 
               
               
                 C02 
                 rs12473666 
                 134639501 
                 T 
                 0.140 
                 28308 
                 0.03 
                 1.10 
                 0.153 
                 2394 
                 0.11 
                 1.07 
                 0.149 
                 3046 
               
               
                 C02 
                 rs10496721 
                 134648929 
                 T 
                 0.175 
                 28306 
                 0.094 
                 1.07 
                 0.185 
                 2394 
                 0.39 
                 1.03 
                 0.179 
                 3046 
               
               
                 C02 
                 rs1257208 
                 134700540 
                 A 
                 0.140 
                 28317 
                 0.017 
                 1.12 
                 0.154 
                 2395 
                 0.0067 
                 1.12 
                 0.154 
                 3047 
               
               
                 C02 
                 rs2268365 
                 169802415 
                 G 
                 0.127 
                 28319 
                 0.038 
                 1.10 
                 0.138 
                 2393 
                 0.045 
                 1.09 
                 0.136 
                 3045 
               
               
                 C02 
                 rs1837241 
                 171017898 
                 A 
                 0.696 
                 28315 
                 0.00086 
                 1.13 
                 0.720 
                 2395 
                 0.0024 
                 1.10 
                 0.716 
                 3047 
               
               
                 C02 
                 rs1399959 
                 172140552 
                 G 
                 0.668 
                 28291 
                 0.0069 
                 1.10 
                 0.688 
                 2393 
                 0.026 
                 1.07 
                 0.683 
                 3044 
               
               
                 C02 
                 rs951917 
                 172220171 
                 T 
                 0.383 
                 28319 
                 0.015 
                 1.08 
                 0.403 
                 2395 
                 0.3 
                 1.03 
                 0.391 
                 3047 
               
               
                 C02 
                 rs4668412 
                 172328016 
                 A 
                 0.709 
                 28319 
                 0.0031 
                 1.11 
                 0.730 
                 2395 
                 0.018 
                 1.08 
                 0.724 
                 3047 
               
               
                 C02 
                 rs6758704 
                 172363343 
                 T 
                 0.709 
                 28303 
                 3.10E−03 
                 1.11 
                 0.730 
                 2395 
                 0.02 
                 1.08 
                 0.724 
                 3047 
               
               
                 C02 
                 rs10165126 
                 172528561 
                 C 
                 0.702 
                 28297 
                 0.00068 
                 1.13 
                 0.727 
                 2394 
                 0.003 
                 1.10 
                 0.721 
                 3046 
               
               
                 C02 
                 rs6718013 
                 172577431 
                 G 
                 0.536 
                 28318 
                 0.0027 
                 1.10 
                 0.560 
                 2395 
                 0.073 
                 1.05 
                 0.549 
                 3047 
               
               
                 C02 
                 rs921083 
                 176453128 
                 G 
                 0.781 
                 28310 
                 0.0092 
                 1.11 
                 0.798 
                 2394 
                 0.04 
                 1.08 
                 0.794 
                 3044 
               
               
                 C02 
                 rs12621733 
                 176499888 
                 G 
                 0.901 
                 28320 
                 0.05 
                 1.12 
                 0.911 
                 2395 
                 0.056 
                 1.10 
                 0.910 
                 3047 
               
               
                 C02 
                 rs1946815 
                 183006405 
                 G 
                 0.219 
                 28310 
                 0.019 
                 1.09 
                 0.235 
                 2395 
                 0.061 
                 1.07 
                 0.231 
                 3047 
               
               
                 C02 
                 rs4666836 
                 183055419 
                 T 
                 0.223 
                 28298 
                 0.075 
                 1.07 
                 0.236 
                 2394 
                 0.15 
                 1.05 
                 0.232 
                 3046 
               
               
                 C02 
                 rs6434921 
                 197828442 
                 A 
                 0.397 
                 28313 
                 0.01 
                 1.09 
                 0.418 
                 2395 
                 0.03 
                 1.07 
                 0.413 
                 3045 
               
               
                 C02 
                 rs6704822 
                 203370024 
                 G 
                 0.915 
                 28086 
                 0.021 
                 1.15 
                 0.926 
                 2380 
                 0.13 
                 1.09 
                 0.922 
                 3030 
               
               
                 C02 
                 rs6435401 
                 208537772 
                 A 
                 0.339 
                 28305 
                 0.015 
                 1.09 
                 0.358 
                 2394 
                 0.025 
                 1.07 
                 0.355 
                 3044 
               
               
                 C02 
                 rs9288396 
                 209243202 
                 T 
                 0.205 
                 28308 
                 0.0077 
                 1.11 
                 0.223 
                 2395 
                 0.0013 
                 1.12 
                 0.225 
                 3047 
               
               
                 C02 
                 rs4442936 
                 211847782 
                 G 
                 0.280 
                 28075 
                 0.00038 
                 1.14 
                 0.307 
                 2367 
                 0.00015 
                 1.13 
                 0.306 
                 3016 
               
               
                 C02 
                 rs12329252 
                 212093968 
                 T 
                 0.681 
                 28321 
                 0.0047 
                 1.11 
                 0.703 
                 2395 
                 0.0059 
                 1.09 
                 0.700 
                 3047 
               
               
                 C02 
                 rs17406681 
                 212111632 
                 T 
                 0.277 
                 28319 
                 0.0075 
                 1.10 
                 0.297 
                 2394 
                 0.022 
                 1.08 
                 0.292 
                 3046 
               
               
                 C02 
                 rs10932529 
                 214852965 
                 A 
                 0.250 
                 28318 
                 2.80E−02 
                 1.09 
                 0.266 
                 2395 
                 0.027 
                 1.08 
                 0.264 
                 3047 
               
               
                 C02 
                 rs2216544 
                 214891122 
                 A 
                 0.257 
                 28310 
                 0.031 
                 1.08 
                 0.273 
                 2395 
                 0.027 
                 1.08 
                 0.272 
                 3047 
               
               
                 C02 
                 rs13417729 
                 215894070 
                 C 
                 0.715 
                 11415 
                 0.0067 
                 1.13 
                 0.739 
                 1775 
                 0.011 
                 1.11 
                 0.736 
                 2094 
               
               
                 C02 
                 rs1478581 
                 218000897 
                 G 
                 0.821 
                 28316 
                 0.0043 
                 1.13 
                 0.839 
                 2395 
                 0.0014 
                 1.13 
                 0.839 
                 3045 
               
               
                 C02 
                 rs9288639 
                 229462042 
                 C 
                 0.080 
                 28295 
                 0.021 
                 1.14 
                 0.091 
                 2392 
                 0.059 
                 1.11 
                 0.088 
                 3042 
               
               
                 C02 
                 rs12617590 
                 234708220 
                 C 
                 0.201 
                 28301 
                 0.0073 
                 1.11 
                 0.219 
                 2395 
                 0.015 
                 1.09 
                 0.215 
                 3047 
               
               
                 C02 
                 rs12052982 
                 241760005 
                 A 
                 0.956 
                 28309 
                 0.00035 
                 1.36 
                 0.967 
                 2393 
                 0.00018 
                 1.34 
                 0.967 
                 3045 
               
               
                 C03 
                 rs17565216 
                 2631107 
                 C 
                 0.366 
                 28306 
                 0.0031 
                 1.10 
                 0.390 
                 2392 
                 0.0033 
                 1.09 
                 0.387 
                 3044 
               
               
                 C03 
                 rs341973 
                 5243162 
                 A 
                 0.508 
                 28284 
                 0.021 
                 1.08 
                 0.527 
                 2393 
                 0.051 
                 1.06 
                 0.523 
                 3044 
               
               
                 C03 
                 rs7638636 
                 6735499 
                 A 
                 0.511 
                 27822 
                 0.031 
                 1.07 
                 0.529 
                 2376 
                 0.11 
                 1.05 
                 0.523 
                 3013 
               
               
                 C03 
                 rs978658 
                 6741178 
                 G 
                 0.615 
                 28313 
                 0.13 
                 1.05 
                 0.627 
                 2394 
                 0.26 
                 1.04 
                 0.623 
                 3046 
               
               
                 C03 
                 rs12491369 
                 6764265 
                 G 
                 0.577 
                 28320 
                 0.31 
                 1.03 
                 0.585 
                 2395 
                 0.63 
                 1.01 
                 0.581 
                 3047 
               
               
                 C03 
                 rs779710 
                 7486375 
                 A 
                 0.596 
                 28311 
                 0.088 
                 1.06 
                 0.610 
                 2395 
                 0.15 
                 1.04 
                 0.607 
                 3047 
               
               
                 C03 
                 rs752299 
                 7494813 
                 T 
                 0.685 
                 11413 
                 1.50E−03 
                 1.15 
                 0.714 
                 1775 
                 0.0056 
                 1.12 
                 0.708 
                 2094 
               
               
                 C03 
                 rs2128163 
                 14269176 
                 G 
                 0.539 
                 28300 
                 0.046 
                 1.07 
                 0.556 
                 2395 
                 0.025 
                 1.07 
                 0.556 
                 3047 
               
               
                 C03 
                 rs6772823 
                 14276852 
                 G 
                 0.280 
                 27955 
                 0.0033 
                 1.11 
                 0.302 
                 2370 
                 0.00061 
                 1.12 
                 0.303 
                 3014 
               
               
                 C03 
                 rs1870480 
                 22619924 
                 G 
                 0.388 
                 28314 
                 0.14 
                 1.05 
                 0.400 
                 2395 
                 0.089 
                 1.05 
                 0.400 
                 3047 
               
               
                 C03 
                 rs6763490 
                 25122716 
                 C 
                 0.600 
                 28310 
                 0.00071 
                 1.12 
                 0.627 
                 2395 
                 0.007 
                 1.09 
                 0.619 
                 3047 
               
               
                 C03 
                 rs13079598 
                 29295837 
                 A 
                 0.906 
                 28315 
                 0.0015 
                 1.20 
                 0.920 
                 2395 
                 0.0022 
                 1.17 
                 0.918 
                 3046 
               
               
                 C03 
                 rs2853705 
                 39306976 
                 T 
                 0.209 
                 28313 
                 0.0043 
                 1.12 
                 0.228 
                 2395 
                 0.0065 
                 1.10 
                 0.226 
                 3047 
               
               
                 C03 
                 rs1530733 
                 54364155 
                 A 
                 0.155 
                 28318 
                 0.029 
                 1.10 
                 0.168 
                 2395 
                 0.033 
                 1.09 
                 0.167 
                 3047 
               
               
                 C03 
                 rs603052 
                 61765300 
                 T 
                 0.778 
                 28301 
                 0.0083 
                 1.11 
                 0.796 
                 2394 
                 0.041 
                 1.08 
                 0.791 
                 3046 
               
               
                 C03 
                 rs1997366 
                 62414626 
                 C 
                 0.798 
                 28304 
                 1.80E−01 
                 1.06 
                 0.807 
                 2394 
                 0.21 
                 1.05 
                 0.805 
                 3045 
               
               
                 C03 
                 rs1534725 
                 62420416 
                 T 
                 0.788 
                 28304 
                 4.80E−02 
                 1.08 
                 0.801 
                 2394 
                 0.041 
                 1.08 
                 0.800 
                 3046 
               
               
                 C03 
                 rs9874646 
                 62437858 
                 T 
                 0.717 
                 28314 
                 0.11 
                 1.06 
                 0.729 
                 2394 
                 0.16 
                 1.05 
                 0.726 
                 3046 
               
               
                 C03 
                 rs1452075 
                 62456103 
                 T 
                 0.739 
                 28228 
                 0.2 
                 1.05 
                 0.748 
                 2386 
                 0.15 
                 1.05 
                 0.748 
                 3033 
               
               
                 C03 
                 rs7653410 
                 63619805 
                 C 
                 0.324 
                 28036 
                 0.01 
                 1.09 
                 0.344 
                 2383 
                 0.051 
                 1.06 
                 0.338 
                 3030 
               
               
                 C03 
                 rs1563545 
                 66782776 
                 G 
                 0.530 
                 28035 
                 1.50E−02 
                 1.08 
                 0.550 
                 2369 
                 0.015 
                 1.07 
                 0.548 
                 3016 
               
               
                 C03 
                 rs2046867 
                 72863765 
                 T 
                 0.279 
                 28307 
                 0.0088 
                 1.10 
                 0.298 
                 2395 
                 0.021 
                 1.08 
                 0.294 
                 3047 
               
               
                 C03 
                 rs7632726 
                 72895436 
                 T 
                 0.310 
                 28319 
                 0.013 
                 1.09 
                 0.329 
                 2395 
                 0.026 
                 1.07 
                 0.325 
                 3047 
               
               
                 C03 
                 rs2208 
                 72954463 
                 A 
                 0.268 
                 28315 
                 0.0087 
                 1.10 
                 0.287 
                 2395 
                 0.024 
                 1.08 
                 0.283 
                 3047 
               
               
                 C03 
                 rs4234186 
                 74348999 
                 A 
                 0.945 
                 28271 
                 0.0037 
                 1.25 
                 0.956 
                 2390 
                 0.13 
                 1.11 
                 0.950 
                 3040 
               
               
                 C03 
                 rs2055707 
                 78706269 
                 A 
                 0.418 
                 28182 
                 0.00039 
                 1.12 
                 0.447 
                 2392 
                 0.0016 
                 1.10 
                 0.441 
                 3044 
               
               
                 C03 
                 rs13075335 
                 83006051 
                 T 
                 0.904 
                 28256 
                 1.60E−02 
                 1.15 
                 0.915 
                 2393 
                 0.047 
                 1.11 
                 0.913 
                 3044 
               
               
                 C03 
                 rs1531377 
                 99825932 
                 T 
                 0.177 
                 28216 
                 0.013 
                 1.11 
                 0.192 
                 2391 
                 0.2 
                 1.05 
                 0.184 
                 3041 
               
               
                 C03 
                 rs3796139 
                 99861391 
                 G 
                 0.150 
                 28071 
                 0.012 
                 1.12 
                 0.165 
                 2375 
                 0.2 
                 1.05 
                 0.157 
                 3018 
               
               
                 C03 
                 rs9847700 
                 124635632 
                 G 
                 0.851 
                 28188 
                 0.00017 
                 1.20 
                 0.872 
                 2345 
                 0.00021 
                 1.17 
                 0.870 
                 2995 
               
               
                 C03 
                 rs6438839 
                 125536191 
                 A 
                 0.078 
                 28316 
                 0.0077 
                 1.17 
                 0.090 
                 2395 
                 0.0044 
                 1.16 
                 0.090 
                 3047 
               
               
                 C03 
                 rs10935515 
                 146038973 
                 C 
                 0.576 
                 26370 
                 0.00024 
                 1.13 
                 0.606 
                 2294 
                 0.00051 
                 1.11 
                 0.602 
                 2902 
               
               
                 C03 
                 rs4401402 
                 146073240 
                 T 
                 0.584 
                 28314 
                 3.20E−03 
                 1.10 
                 0.608 
                 2394 
                 0.0032 
                 1.09 
                 0.606 
                 3046 
               
               
                 C03 
                 rs13061557 
                 146128702 
                 T 
                 0.698 
                 28295 
                 0.092 
                 1.06 
                 0.710 
                 2395 
                 0.13 
                 1.05 
                 0.708 
                 3047 
               
               
                 C03 
                 rs10935523 
                 146138781 
                 A 
                 0.740 
                 28317 
                 0.036 
                 1.08 
                 0.754 
                 2395 
                 0.026 
                 1.08 
                 0.754 
                 3047 
               
               
                 C03 
                 rs1430435 
                 170561887 
                 G 
                 0.501 
                 28314 
                 0.017 
                 1.08 
                 0.521 
                 2395 
                 0.056 
                 1.06 
                 0.515 
                 3047 
               
               
                 C03 
                 rs756644 
                 170567521 
                 A 
                 0.429 
                 28313 
                 2.20E−03 
                 1.11 
                 0.454 
                 2394 
                 0.023 
                 1.07 
                 0.446 
                 3046 
               
               
                 C03 
                 rs1549100 
                 175400363 
                 T 
                 0.732 
                 28237 
                 0.078 
                 1.07 
                 0.745 
                 2386 
                 0.28 
                 1.04 
                 0.739 
                 3038 
               
               
                 C03 
                 rs1421420 
                 175408319 
                 A 
                 0.727 
                 28307 
                 0.037 
                 1.08 
                 0.742 
                 2395 
                 0.15 
                 1.05 
                 0.737 
                 3047 
               
               
                 C03 
                 rs2111956 
                 175432500 
                 G 
                 0.763 
                 28317 
                 0.043 
                 1.08 
                 0.777 
                 2395 
                 0.099 
                 1.06 
                 0.773 
                 3046 
               
               
                 C03 
                 rs6803944 
                 186606110 
                 C 
                 0.845 
                 28320 
                 0.0084 
                 1.13 
                 0.860 
                 2395 
                 0.012 
                 1.11 
                 0.858 
                 3047 
               
               
                 C03 
                 rs9864293 
                 191695400 
                 C 
                 0.387 
                 28308 
                 0.00012 
                 1.14 
                 0.418 
                 2395 
                 0.00013 
                 1.12 
                 0.415 
                 3046 
               
               
                 C03 
                 rs883279 
                 194931805 
                 C 
                 0.907 
                 28311 
                 0.061 
                 1.11 
                 0.916 
                 2394 
                 0.03 
                 1.12 
                 0.916 
                 3046 
               
               
                 C03 
                 rs4497978 
                 195990481 
                 A 
                 0.666 
                 28228 
                 0.00031 
                 1.14 
                 0.694 
                 2375 
                 0.0019 
                 1.10 
                 0.688 
                 3023 
               
               
                 C04 
                 rs6822427 
                 3749870 
                 A 
                 0.488 
                 28256 
                 0.022 
                 1.08 
                 0.506 
                 2391 
                 0.016 
                 1.07 
                 0.506 
                 3040 
               
               
                 C04 
                 rs3756193 
                 8284241 
                 G 
                 0.461 
                 28262 
                 0.0072 
                 1.09 
                 0.483 
                 2393 
                 0.004 
                 1.09 
                 0.482 
                 3043 
               
               
                 C04 
                 rs714086 
                 9922140 
                 G 
                 0.761 
                 28317 
                 0.013 
                 1.10 
                 0.778 
                 2395 
                 0.11 
                 1.06 
                 0.771 
                 3047 
               
               
                 C04 
                 rs4697653 
                 10337857 
                 G 
                 0.524 
                 28161 
                 0.0021 
                 1.11 
                 0.549 
                 2392 
                 0.0081 
                 1.08 
                 0.543 
                 3040 
               
               
                 C04 
                 rs2170752 
                 10493178 
                 T 
                 0.576 
                 28317 
                 0.011 
                 1.09 
                 0.597 
                 2395 
                 0.077 
                 1.05 
                 0.589 
                 3047 
               
               
                 C04 
                 rs959233 
                 10511257 
                 G 
                 0.446 
                 28291 
                 2.60E−02 
                 1.08 
                 0.464 
                 2394 
                 0.02 
                 1.07 
                 0.463 
                 3044 
               
               
                 C04 
                 rs10011464 
                 10515465 
                 T 
                 0.462 
                 28191 
                 0.031 
                 1.07 
                 0.480 
                 2375 
                 0.038 
                 1.06 
                 0.478 
                 3025 
               
               
                 C04 
                 rs7442366 
                 16944686 
                 T 
                 0.824 
                 28321 
                 0.024 
                 1.10 
                 0.838 
                 2395 
                 0.066 
                 1.08 
                 0.835 
                 3047 
               
               
                 C04 
                 rs2697684 
                 17045056 
                 G 
                 0.774 
                 28318 
                 0.033 
                 1.09 
                 0.788 
                 2395 
                 0.018 
                 1.09 
                 0.788 
                 3047 
               
               
                 C04 
                 rs1827591 
                 21341284 
                 G 
                 0.538 
                 28319 
                 0.0079 
                 1.09 
                 0.560 
                 2395 
                 0.012 
                 1.08 
                 0.557 
                 3047 
               
               
                 C04 
                 rs6448072 
                 21352329 
                 C 
                 0.659 
                 28318 
                 0.017 
                 1.09 
                 0.677 
                 2395 
                 0.009 
                 1.09 
                 0.677 
                 3047 
               
               
                 C04 
                 rs10516402 
                 21407661 
                 C 
                 0.505 
                 28313 
                 0.0023 
                 1.10 
                 0.530 
                 2394 
                 0.0024 
                 1.09 
                 0.527 
                 3046 
               
               
                 C04 
                 rs4282162 
                 21426819 
                 T 
                 0.530 
                 28305 
                 0.002 
                 1.11 
                 0.555 
                 2395 
                 0.0031 
                 1.09 
                 0.552 
                 3047 
               
               
                 C04 
                 rs4377576 
                 21434824 
                 C 
                 0.541 
                 28316 
                 0.0034 
                 1.10 
                 0.565 
                 2395 
                 0.0044 
                 1.09 
                 0.562 
                 3047 
               
               
                 C04 
                 rs2060515 
                 29994854 
                 T 
                 0.114 
                 28189 
                 0.059 
                 1.10 
                 0.124 
                 2379 
                 0.064 
                 1.09 
                 0.123 
                 3028 
               
               
                 C04 
                 rs4132132 
                 30610399 
                 G 
                 0.451 
                 28229 
                 0.12 
                 1.05 
                 0.464 
                 2390 
                 0.17 
                 1.04 
                 0.461 
                 3040 
               
               
                 C04 
                 rs10517277 
                 33143198 
                 C 
                 0.102 
                 28290 
                 0.0086 
                 1.15 
                 0.115 
                 2394 
                 0.041 
                 1.10 
                 0.111 
                 3046 
               
               
                 C04 
                 rs3849018 
                 37325240 
                 T 
                 0.280 
                 28319 
                 0.003 
                 1.11 
                 0.301 
                 2395 
                 0.0016 
                 1.11 
                 0.301 
                 3046 
               
               
                 C04 
                 rs4447895 
                 40092010 
                 C 
                 0.887 
                 28318 
                 0.015 
                 1.14 
                 0.899 
                 2395 
                 0.0087 
                 1.13 
                 0.899 
                 3047 
               
               
                 C04 
                 rs6447404 
                 44714926 
                 G 
                 0.620 
                 11414 
                 0.015 
                 1.10 
                 0.643 
                 1775 
                 0.048 
                 1.08 
                 0.638 
                 2094 
               
               
                 C04 
                 rs7661204 
                 45728007 
                 T 
                 0.449 
                 28320 
                 0.0055 
                 0.91 
                 0.427 
                 2395 
                 0.00074 
                 0.91 
                 0.425 
                 3047 
               
               
                 C04 
                 rs10026644 
                 82020315 
                 G 
                 0.924 
                 27964 
                 0.0003 
                 1.27 
                 0.939 
                 2382 
                 0.01 
                 1.16 
                 0.933 
                 3028 
               
               
                 C04 
                 rs10026120 
                 82037699 
                 T 
                 0.959 
                 28199 
                 0.006 
                 1.28 
                 0.968 
                 2393 
                 0.03 
                 1.19 
                 0.965 
                 3040 
               
               
                 C04 
                 rs6830629 
                 82083395 
                 A 
                 0.975 
                 28273 
                 0.0036 
                 1.39 
                 0.982 
                 2393 
                 0.034 
                 1.24 
                 0.979 
                 3043 
               
               
                 C04 
                 rs2589506 
                 87158716 
                 G 
                 0.456 
                 28313 
                 0.018 
                 1.08 
                 0.475 
                 2395 
                 0.0053 
                 1.09 
                 0.476 
                 3047 
               
               
                 C04 
                 rs2199309 
                 87318595 
                 C 
                 0.219 
                 26388 
                 0.022 
                 1.10 
                 0.235 
                 2276 
                 0.0032 
                 1.11 
                 0.238 
                 2883 
               
               
                 C04 
                 rs10516770 
                 87391122 
                 T 
                 0.056 
                 28310 
                 0.083 
                 1.13 
                 0.062 
                 2395 
                 0.014 
                 1.16 
                 0.064 
                 3047 
               
               
                 C04 
                 rs2924936 
                 89860537 
                 G 
                 0.871 
                 28318 
                 0.11 
                 1.08 
                 0.879 
                 2395 
                 0.019 
                 1.11 
                 0.882 
                 3047 
               
               
                 C04 
                 rs13130 
                 89867868 
                 T 
                 0.872 
                 28227 
                 0.11 
                 1.08 
                 0.880 
                 2388 
                 0.019 
                 1.11 
                 0.883 
                 3039 
               
               
                 C04 
                 rs6850673 
                 96366883 
                 C 
                 0.142 
                 28314 
                 0.014 
                 1.12 
                 0.156 
                 2394 
                 0.0082 
                 1.12 
                 0.156 
                 3046 
               
               
                 C04 
                 rs10516987 
                 97050762 
                 G 
                 0.798 
                 28265 
                 0.0073 
                 1.12 
                 0.815 
                 2385 
                 0.019 
                 1.09 
                 0.812 
                 3035 
               
               
                 C04 
                 rs1982346 
                 106798203 
                 C 
                 0.058 
                 27647 
                 0.00038 
                 1.26 
                 0.072 
                 2352 
                 0.0016 
                 1.21 
                 0.069 
                 2991 
               
               
                 C04 
                 rs6820367 
                 119312058 
                 A 
                 0.353 
                 28319 
                 0.036 
                 1.07 
                 0.369 
                 2395 
                 0.078 
                 1.06 
                 0.365 
                 3047 
               
               
                 C04 
                 rs6534683 
                 129601758 
                 T 
                 0.656 
                 28310 
                 0.076 
                 1.06 
                 0.670 
                 2395 
                 0.034 
                 1.07 
                 0.671 
                 3047 
               
               
                 C04 
                 rs7690289 
                 129628963 
                 T 
                 0.637 
                 27978 
                 0.028 
                 1.08 
                 0.654 
                 2381 
                 0.0076 
                 1.09 
                 0.655 
                 3023 
               
               
                 C04 
                 rs4549394 
                 129650748 
                 T 
                 0.102 
                 28313 
                 0.094 
                 1.09 
                 0.110 
                 2395 
                 0.14 
                 1.07 
                 0.108 
                 3047 
               
               
                 C04 
                 rs4383635 
                 131414021 
                 A 
                 0.491 
                 28225 
                 0.031 
                 1.07 
                 0.508 
                 2394 
                 0.0099 
                 1.08 
                 0.510 
                 3045 
               
               
                 C04 
                 rs1027884 
                 131431891 
                 T 
                 0.497 
                 28311 
                 0.02 
                 1.08 
                 0.516 
                 2395 
                 0.0072 
                 1.08 
                 0.517 
                 3047 
               
               
                 C04 
                 rs4864193 
                 134641403 
                 C 
                 0.961 
                 28307 
                 0.16 
                 1.13 
                 0.965 
                 2395 
                 0.15 
                 1.12 
                 0.965 
                 3047 
               
               
                 C04 
                 rs10028163 
                 138689635 
                 G 
                 0.207 
                 28316 
                 0.0012 
                 1.14 
                 0.228 
                 2395 
                 0.00075 
                 1.13 
                 0.227 
                 3047 
               
               
                 C04 
                 rs7669668 
                 139472904 
                 T 
                 0.123 
                 28319 
                 0.02 
                 1.12 
                 0.136 
                 2395 
                 0.16 
                 1.06 
                 0.130 
                 3047 
               
               
                 C04 
                 rs723794 
                 147095001 
                 T 
                 0.773 
                 28318 
                 0.011 
                 1.11 
                 0.791 
                 2395 
                 0.037 
                 1.08 
                 0.786 
                 3047 
               
               
                 C04 
                 rs2241521 
                 147218561 
                 A 
                 0.239 
                 28318 
                 0.03 
                 1.09 
                 0.254 
                 2395 
                 0.017 
                 1.09 
                 0.255 
                 3047 
               
               
                 C04 
                 rs17326199 
                 161219141 
                 G 
                 0.214 
                 28307 
                 0.0099 
                 1.11 
                 0.231 
                 2393 
                 0.0041 
                 1.11 
                 0.231 
                 3045 
               
               
                 C04 
                 rs17359034 
                 161797877 
                 T 
                 0.390 
                 28227 
                 0.011 
                 1.09 
                 0.410 
                 2394 
                 0.044 
                 1.06 
                 0.404 
                 3046 
               
               
                 C04 
                 rs12503470 
                 162109433 
                 T 
                 0.383 
                 28267 
                 0.049 
                 1.07 
                 0.399 
                 2394 
                 0.019 
                 1.07 
                 0.400 
                 3046 
               
               
                 C04 
                 rs9942159 
                 162382460 
                 T 
                 0.380 
                 28203 
                 0.005 
                 1.10 
                 0.402 
                 2383 
                 0.0029 
                 1.09 
                 0.401 
                 3034 
               
               
                 C04 
                 rs958247 
                 162412247 
                 A 
                 0.289 
                 28271 
                 0.0036 
                 1.11 
                 0.310 
                 2393 
                 0.0014 
                 1.11 
                 0.310 
                 3043 
               
               
                 C04 
                 rs9991428 
                 163627494 
                 G 
                 0.961 
                 28297 
                 0.0014 
                 1.34 
                 0.971 
                 2394 
                 0.0013 
                 1.30 
                 0.970 
                 3046 
               
               
                 C04 
                 rs11723570 
                 165962251 
                 C 
                 0.509 
                 28320 
                 0.002 
                 1.11 
                 0.534 
                 2395 
                 0.0019 
                 1.10 
                 0.532 
                 3047 
               
               
                 C04 
                 rs4695894 
                 175054285 
                 G 
                 0.500 
                 28257 
                 0.0079 
                 1.09 
                 0.522 
                 2393 
                 0.017 
                 1.07 
                 0.518 
                 3043 
               
               
                 C04 
                 rs309770 
                 177690442 
                 G 
                 0.891 
                 28321 
                 0.027 
                 1.13 
                 0.902 
                 2395 
                 0.073 
                 1.09 
                 0.899 
                 3047 
               
               
                 C04 
                 rs309800 
                 177704874 
                 C 
                 0.799 
                 28259 
                 0.019 
                 1.10 
                 0.814 
                 2391 
                 0.01 
                 1.10 
                 0.814 
                 3043 
               
               
                 C04 
                 rs1983130 
                 178505657 
                 G 
                 0.415 
                 28301 
                 0.022 
                 1.08 
                 0.434 
                 2394 
                 0.073 
                 1.06 
                 0.428 
                 3045 
               
               
                 C04 
                 rs17090640 
                 180904641 
                 G 
                 0.952 
                 28319 
                 6.70E−03 
                 1.24 
                 0.961 
                 2395 
                 0.029 
                 1.17 
                 0.958 
                 3047 
               
               
                 C05 
                 rs1697952 
                 667963 
                 C 
                 0.374 
                 28278 
                 0.035 
                 1.07 
                 0.391 
                 2392 
                 0.052 
                 1.06 
                 0.388 
                 3043 
               
               
                 C05 
                 rs1697997 
                 3595548 
                 A 
                 0.918 
                 28300 
                 0.0099 
                 1.17 
                 0.929 
                 2395 
                 0.014 
                 1.15 
                 0.928 
                 3046 
               
               
                 C05 
                 rs710998 
                 3644916 
                 T 
                 0.903 
                 28254 
                 0.0014 
                 1.20 
                 0.918 
                 2390 
                 0.0045 
                 1.16 
                 0.915 
                 3040 
               
               
                 C05 
                 rs11956711 
                 3978083 
                 C 
                 0.066 
                 28288 
                 0.0047 
                 1.19 
                 0.077 
                 2393 
                 0.021 
                 1.14 
                 0.074 
                 3044 
               
               
                 C05 
                 rs634344 
                 3997125 
                 G 
                 0.066 
                 28294 
                 0.0042 
                 1.20 
                 0.078 
                 2392 
                 0.019 
                 1.14 
                 0.074 
                 3042 
               
               
                 C05 
                 rs864267 
                 5893433 
                 A 
                 0.451 
                 28310 
                 0.0023 
                 1.10 
                 0.476 
                 2394 
                 0.0083 
                 1.08 
                 0.470 
                 3046 
               
               
                 C05 
                 rs2617549 
                 5904873 
                 A 
                 0.453 
                 28283 
                 0.0023 
                 1.11 
                 0.477 
                 2393 
                 0.0072 
                 1.08 
                 0.472 
                 3045 
               
               
                 C05 
                 rs1457122 
                 6326004 
                 T 
                 0.338 
                 28304 
                 0.03 
                 1.08 
                 0.354 
                 2395 
                 0.081 
                 1.06 
                 0.350 
                 3047 
               
               
                 C05 
                 rs870347 
                 6898035 
                 T 
                 0.926 
                 28313 
                 0.0052 
                 1.20 
                 0.937 
                 2395 
                 0.0088 
                 1.17 
                 0.936 
                 3047 
               
               
                 C05 
                 rs3213627 
                 9694628 
                 T 
                 0.172 
                 28296 
                 0.0025 
                 1.14 
                 0.191 
                 2393 
                 0.03 
                 1.09 
                 0.184 
                 3045 
               
               
                 C05 
                 rs2106687 
                 9700012 
                 G 
                 0.130 
                 28310 
                 0.0055 
                 1.14 
                 0.146 
                 2395 
                 0.074 
                 1.08 
                 0.139 
                 3046 
               
               
                 C05 
                 rs16883905 
                 10009338 
                 T 
                 0.112 
                 28320 
                 0.00056 
                 1.19 
                 0.130 
                 2395 
                 0.00012 
                 1.19 
                 0.130 
                 3047 
               
               
                 C05 
                 rs30616 
                 14320173 
                 T 
                 0.852 
                 28316 
                 0.0016 
                 1.16 
                 0.870 
                 2395 
                 0.0018 
                 1.14 
                 0.868 
                 3047 
               
               
                 C05 
                 rs7715223 
                 15953124 
                 C 
                 0.819 
                 28263 
                 0.0012 
                 1.15 
                 0.839 
                 2384 
                 0.021 
                 1.09 
                 0.832 
                 3036 
               
               
                 C05 
                 rs11743379 
                 23752107 
                 T 
                 0.514 
                 28310 
                 0.093 
                 1.06 
                 0.528 
                 2395 
                 0.096 
                 1.05 
                 0.527 
                 3047 
               
               
                 C05 
                 rs1382932 
                 26922341 
                 C 
                 0.683 
                 28294 
                 0.0083 
                 1.10 
                 0.703 
                 2393 
                 0.0093 
                 1.09 
                 0.701 
                 3045 
               
               
                 C05 
                 rs6875512 
                 31367532 
                 A 
                 0.743 
                 28305 
                 0.011 
                 1.10 
                 0.760 
                 2395 
                 0.021 
                 1.08 
                 0.757 
                 3047 
               
               
                 C05 
                 rs525735 
                 38917385 
                 C 
                 0.777 
                 28312 
                 0.064 
                 1.08 
                 0.789 
                 2394 
                 0.18 
                 1.05 
                 0.785 
                 3046 
               
               
                 C05 
                 rs357291 
                 38959536 
                 C 
                 0.403 
                 28138 
                 0.048 
                 1.07 
                 0.418 
                 2377 
                 0.18 
                 1.04 
                 0.412 
                 3025 
               
               
                 C05 
                 rs9292729 
                 39061343 
                 C 
                 0.345 
                 28300 
                 0.044 
                 1.07 
                 0.361 
                 2395 
                 0.14 
                 1.05 
                 0.356 
                 3047 
               
               
                 C05 
                 rs6880882 
                 39112718 
                 A 
                 0.360 
                 28252 
                 0.051 
                 1.07 
                 0.375 
                 2389 
                 0.13 
                 1.05 
                 0.370 
                 3039 
               
               
                 C05 
                 rs444556 
                 39149695 
                 C 
                 0.310 
                 28223 
                 0.024 
                 1.08 
                 0.327 
                 2391 
                 0.085 
                 1.06 
                 0.322 
                 3040 
               
               
                 C05 
                 rs13165359 
                 40271560 
                 G 
                 0.881 
                 28320 
                 0.031 
                 1.12 
                 0.892 
                 2395 
                 0.16 
                 1.07 
                 0.888 
                 3047 
               
               
                 C05 
                 rs13175020 
                 40646263 
                 T 
                 0.817 
                 28309 
                 0.0022 
                 1.14 
                 0.836 
                 2393 
                 0.01 
                 1.11 
                 0.831 
                 3045 
               
               
                 C05 
                 rs10038238 
                 50797350 
                 A 
                 0.569 
                 28268 
                 0.00027 
                 1.13 
                 0.598 
                 2393 
                 0.0007 
                 1.11 
                 0.594 
                 3043 
               
               
                 C05 
                 rs1423611 
                 50806871 
                 C 
                 0.443 
                 28301 
                 0.00032 
                 1.12 
                 0.472 
                 2395 
                 0.0051 
                 1.09 
                 0.464 
                 3047 
               
               
                 C05 
                 rs6449708 
                 50887332 
                 T 
                 0.456 
                 27678 
                 0.00067 
                 1.12 
                 0.484 
                 2369 
                 0.0026 
                 1.09 
                 0.479 
                 3009 
               
               
                 C05 
                 rs7708362 
                 50924592 
                 T 
                 0.348 
                 28252 
                 0.0041 
                 1.10 
                 0.370 
                 2381 
                 0.02 
                 1.07 
                 0.364 
                 3033 
               
               
                 C05 
                 rs4865673 
                 50964567 
                 G 
                 0.647 
                 28318 
                 0.0086 
                 1.09 
                 0.668 
                 2395 
                 0.0038 
                 1.09 
                 0.668 
                 3046 
               
               
                 C05 
                 rs38055 
                 52596401 
                 T 
                 0.387 
                 28311 
                 0.052 
                 1.07 
                 0.403 
                 2395 
                 0.091 
                 1.05 
                 0.399 
                 3047 
               
               
                 C05 
                 rs32496 
                 55677396 
                 C 
                 0.576 
                 28296 
                 0.0066 
                 1.09 
                 0.598 
                 2395 
                 0.029 
                 1.07 
                 0.592 
                 3046 
               
               
                 C05 
                 rs30365 
                 55864542 
                 C 
                 0.900 
                 28303 
                 0.0018 
                 1.19 
                 0.914 
                 2395 
                 0.019 
                 1.13 
                 0.910 
                 3046 
               
               
                 C05 
                 rs7720499 
                 56057578 
                 T 
                 0.112 
                 28276 
                 0.0075 
                 1.14 
                 0.126 
                 2394 
                 0.0037 
                 1.14 
                 0.125 
                 3045 
               
               
                 C05 
                 rs4700485 
                 56069964 
                 A 
                 0.326 
                 28316 
                 0.013 
                 1.09 
                 0.345 
                 2395 
                 0.039 
                 1.07 
                 0.340 
                 3047 
               
               
                 C05 
                 rs12657615 
                 56099890 
                 C 
                 0.116 
                 28319 
                 0.012 
                 1.13 
                 0.129 
                 2395 
                 0.0046 
                 1.14 
                 0.129 
                 3047 
               
               
                 C05 
                 rs832540 
                 56234959 
                 C 
                 0.422 
                 28307 
                 0.0061 
                 1.09 
                 0.444 
                 2395 
                 0.0043 
                 1.09 
                 0.443 
                 3047 
               
               
                 C05 
                 rs252890 
                 56262167 
                 A 
                 0.430 
                 27978 
                 0.015 
                 1.08 
                 0.450 
                 2373 
                 0.0087 
                 1.08 
                 0.450 
                 3012 
               
               
                 C05 
                 rs1445998 
                 56303962 
                 A 
                 0.406 
                 28292 
                 0.015 
                 1.08 
                 0.425 
                 2393 
                 0.004 
                 1.09 
                 0.427 
                 3045 
               
               
                 C05 
                 rs2408654 
                 56318303 
                 C 
                 0.274 
                 28293 
                 0.0045 
                 1.11 
                 0.295 
                 2395 
                 0.0025 
                 1.10 
                 0.294 
                 3047 
               
               
                 C05 
                 rs2962014 
                 57506028 
                 G 
                 0.504 
                 27810 
                 0.051 
                 1.07 
                 0.520 
                 2365 
                 0.069 
                 1.06 
                 0.518 
                 3011 
               
               
                 C05 
                 rs2112905 
                 57520064 
                 A 
                 0.405 
                 28312 
                 0.015 
                 1.08 
                 0.424 
                 2395 
                 0.012 
                 1.08 
                 0.423 
                 3047 
               
               
                 C05 
                 rs2441109 
                 66174994 
                 G 
                 0.164 
                 28313 
                 0.017 
                 1.11 
                 0.178 
                 2395 
                 0.042 
                 1.08 
                 0.175 
                 3047 
               
               
                 C05 
                 rs39700 
                 66197800 
                 G 
                 0.375 
                 28315 
                 0.034 
                 1.07 
                 0.391 
                 2394 
                 0.05 
                 1.06 
                 0.389 
                 3046 
               
               
                 C05 
                 rs974280 
                 76535005 
                 G 
                 0.358 
                 28315 
                 0.0013 
                 1.11 
                 0.383 
                 2395 
                 0.0011 
                 1.10 
                 0.381 
                 3047 
               
               
                 C05 
                 rs4704400 
                 76586766 
                 T 
                 0.498 
                 28306 
                 0.0057 
                 1.09 
                 0.520 
                 2394 
                 0.023 
                 1.07 
                 0.514 
                 3046 
               
               
                 C05 
                 rs251421 
                 76608726 
                 C 
                 0.262 
                 28278 
                 0.02 
                 1.09 
                 0.278 
                 2383 
                 0.063 
                 1.06 
                 0.274 
                 3033 
               
               
                 C05 
                 rs3816609 
                 76757694 
                 A 
                 0.359 
                 28316 
                 0.03 
                 1.08 
                 0.376 
                 2395 
                 0.049 
                 1.06 
                 0.373 
                 3047 
               
               
                 C05 
                 rs690280 
                 76794989 
                 T 
                 0.429 
                 28241 
                 0.027 
                 1.08 
                 0.447 
                 2388 
                 0.1 
                 1.05 
                 0.441 
                 3040 
               
               
                 C05 
                 rs251470 
                 76814241 
                 T 
                 0.445 
                 28294 
                 0.02 
                 1.08 
                 0.464 
                 2395 
                 0.081 
                 1.05 
                 0.458 
                 3047 
               
               
                 C05 
                 rs6452479 
                 82055874 
                 C 
                 0.936 
                 28169 
                 0.014 
                 1.19 
                 0.945 
                 2384 
                 0.0067 
                 1.19 
                 0.945 
                 3032 
               
               
                 C05 
                 rs6556861 
                 94554256 
                 G 
                 0.570 
                 28317 
                 0.0082 
                 1.09 
                 0.591 
                 2395 
                 0.006 
                 1.09 
                 0.590 
                 3047 
               
               
                 C05 
                 rs464906 
                 94633980 
                 C 
                 0.619 
                 28287 
                 0.049 
                 1.07 
                 0.635 
                 2394 
                 0.051 
                 1.06 
                 0.633 
                 3045 
               
               
                 C05 
                 rs950195 
                 97466690 
                 G 
                 0.633 
                 28228 
                 0.0033 
                 1.11 
                 0.656 
                 2395 
                 0.002 
                 1.10 
                 0.654 
                 3046 
               
               
                 C05 
                 rs168654 
                 97924372 
                 T 
                 0.641 
                 28309 
                 0.053 
                 1.07 
                 0.656 
                 2394 
                 0.07 
                 1.06 
                 0.654 
                 3046 
               
               
                 C05 
                 rs3776859 
                 102379933 
                 T 
                 0.709 
                 28311 
                 0.001 
                 1.13 
                 0.733 
                 2395 
                 0.0067 
                 1.09 
                 0.727 
                 3046 
               
               
                 C05 
                 rs26434 
                 102391301 
                 T 
                 0.705 
                 28286 
                 0.0012 
                 1.12 
                 0.729 
                 2391 
                 0.0098 
                 1.09 
                 0.722 
                 3042 
               
               
                 C05 
                 rs9327877 
                 102409540 
                 T 
                 0.194 
                 28309 
                 0.00071 
                 1.15 
                 0.216 
                 2395 
                 0.0026 
                 1.12 
                 0.212 
                 3046 
               
               
                 C05 
                 rs34374 
                 102431920 
                 A 
                 0.673 
                 28279 
                 2.70E−03 
                 1.11 
                 0.696 
                 2394 
                 0.016 
                 1.08 
                 0.690 
                 3046 
               
               
                 C05 
                 rs34813 
                 102461308 
                 G 
                 0.710 
                 28316 
                 0.0015 
                 1.12 
                 0.733 
                 2395 
                 0.011 
                 1.09 
                 0.727 
                 3047 
               
               
                 C05 
                 rs183752 
                 102535711 
                 T 
                 0.717 
                 28280 
                 0.0027 
                 1.12 
                 0.739 
                 2394 
                 0.021 
                 1.08 
                 0.733 
                 3046 
               
               
                 C05 
                 rs26821 
                 102548299 
                 A 
                 0.710 
                 28196 
                 0.0014 
                 1.12 
                 0.733 
                 2389 
                 0.011 
                 1.09 
                 0.727 
                 3041 
               
               
                 C05 
                 rs4957775 
                 108007478 
                 G 
                 0.837 
                 28311 
                 0.0013 
                 1.16 
                 0.856 
                 2395 
                 0.0008 
                 1.15 
                 0.854 
                 3047 
               
               
                 C05 
                 rs9326981 
                 115348507 
                 C 
                 0.950 
                 28315 
                 0.076 
                 1.15 
                 0.956 
                 2395 
                 0.16 
                 1.10 
                 0.954 
                 3047 
               
               
                 C05 
                 rs17138668 
                 115379140 
                 C 
                 0.948 
                 28317 
                 0.0041 
                 1.25 
                 0.958 
                 2395 
                 0.014 
                 1.19 
                 0.956 
                 3047 
               
               
                 C05 
                 rs728676 
                 118087433 
                 T 
                 0.444 
                 28310 
                 0.0023 
                 1.10 
                 0.468 
                 2394 
                 0.001 
                 1.10 
                 0.468 
                 3046 
               
               
                 C05 
                 rs7721883 
                 119467718 
                 T 
                 0.466 
                 28215 
                 0.0048 
                 1.10 
                 0.489 
                 2390 
                 0.04 
                 1.06 
                 0.482 
                 3041 
               
               
                 C05 
                 rs9327287 
                 122547512 
                 G 
                 0.263 
                 28313 
                 0.012 
                 1.10 
                 0.281 
                 2395 
                 0.091 
                 1.06 
                 0.274 
                 3047 
               
               
                 C05 
                 rs1476097 
                 133864960 
                 T 
                 0.658 
                 28313 
                 0.0025 
                 1.11 
                 0.681 
                 2394 
                 0.03 
                 1.07 
                 0.673 
                 3045 
               
               
                 C05 
                 rs4141140 
                 135980112 
                 G 
                 0.701 
                 28318 
                 0.0043 
                 1.11 
                 0.723 
                 2395 
                 0.0031 
                 1.10 
                 0.721 
                 3046 
               
               
                 C05 
                 rs1870739 
                 153183640 
                 C 
                 0.853 
                 28308 
                 0.015 
                 1.12 
                 0.866 
                 2392 
                 0.037 
                 1.09 
                 0.863 
                 3044 
               
               
                 C05 
                 rs1461236 
                 153221364 
                 T 
                 0.854 
                 28176 
                 0.015 
                 1.12 
                 0.868 
                 2381 
                 0.039 
                 1.09 
                 0.865 
                 3031 
               
               
                 C05 
                 rs716376 
                 157479655 
                 G 
                 0.189 
                 28314 
                 0.034 
                 1.09 
                 0.202 
                 2395 
                 0.13 
                 1.06 
                 0.197 
                 3046 
               
               
                 C05 
                 rs2964513 
                 157878493 
                 A 
                 0.696 
                 28222 
                 0.025 
                 1.08 
                 0.713 
                 2389 
                 0.35 
                 1.03 
                 0.702 
                 3040 
               
               
                 C05 
                 rs7442701 
                 158456100 
                 T 
                 0.181 
                 28293 
                 0.00051 
                 1.15 
                 0.203 
                 2394 
                 0.005 
                 1.11 
                 0.197 
                 3046 
               
               
                 C05 
                 rs7447732 
                 158461713 
                 C 
                 0.320 
                 28280 
                 0.0033 
                 1.11 
                 0.343 
                 2393 
                 0.015 
                 1.08 
                 0.337 
                 3045 
               
               
                 C05 
                 rs270661 
                 158492732 
                 A 
                 0.210 
                 28319 
                 0.011 
                 1.11 
                 0.227 
                 2394 
                 0.025 
                 1.08 
                 0.223 
                 3046 
               
               
                 C05 
                 rs270654 
                 158497687 
                 G 
                 0.137 
                 28318 
                 0.012 
                 1.12 
                 0.151 
                 2395 
                 0.021 
                 1.10 
                 0.149 
                 3047 
               
               
                 C05 
                 rs254850 
                 158599309 
                 T 
                 0.220 
                 28316 
                 0.0011 
                 1.13 
                 0.242 
                 2395 
                 0.0082 
                 1.10 
                 0.236 
                 3047 
               
               
                 C05 
                 rs4921437 
                 158623529 
                 T 
                 0.216 
                 28259 
                 0.00049 
                 1.14 
                 0.240 
                 2386 
                 0.0022 
                 1.11 
                 0.235 
                 3037 
               
               
                 C05 
                 rs1433048 
                 158688423 
                 G 
                 0.193 
                 27899 
                 0.0074 
                 1.12 
                 0.211 
                 2344 
                 0.021 
                 1.09 
                 0.207 
                 2989 
               
               
                 C05 
                 rs7709212 
                 158696755 
                 T 
                 0.680 
                 28305 
                 0.004 
                 1.11 
                 0.702 
                 2394 
                 0.0061 
                 1.09 
                 0.699 
                 3046 
               
               
                 C05 
                 rs953861 
                 158705160 
                 G 
                 0.161 
                 28318 
                 0.0027 
                 1.14 
                 0.180 
                 2395 
                 0.052 
                 1.08 
                 0.172 
                 3047 
               
               
                 C05 
                 rs10045431 
                 158747111 
                 A 
                 0.266 
                 28238 
                 0.011 
                 1.10 
                 0.285 
                 2364 
                 0.095 
                 1.06 
                 0.277 
                 3014 
               
               
                 C05 
                 rs889053 
                 159028256 
                 T 
                 0.159 
                 28319 
                 0.012 
                 1.12 
                 0.174 
                 2395 
                 0.016 
                 1.10 
                 0.172 
                 3047 
               
               
                 C05 
                 rs7705176 
                 167424970 
                 G 
                 0.786 
                 28317 
                 0.15 
                 1.06 
                 0.796 
                 2395 
                 0.37 
                 1.03 
                 0.791 
                 3047 
               
               
                 C05 
                 rs7736530 
                 167453404 
                 G 
                 0.802 
                 28315 
                 0.093 
                 1.07 
                 0.813 
                 2395 
                 0.14 
                 1.06 
                 0.811 
                 3047 
               
               
                 C05 
                 rs2617972 
                 167476408 
                 C 
                 0.813 
                 28316 
                 0.095 
                 1.07 
                 0.824 
                 2393 
                 0.29 
                 1.04 
                 0.819 
                 3045 
               
               
                 C05 
                 rs1077046 
                 167478603 
                 C 
                 0.554 
                 28303 
                 0.0099 
                 1.09 
                 0.575 
                 2395 
                 0.064 
                 1.06 
                 0.567 
                 3047 
               
               
                 C05 
                 rs7724098 
                 176592176 
                 G 
                 0.289 
                 28310 
                 0.007 
                 1.10 
                 0.309 
                 2392 
                 0.034 
                 1.07 
                 0.304 
                 3044 
               
               
                 C05 
                 rs3756566 
                 178509237 
                 G 
                 0.404 
                 28315 
                 0.0033 
                 1.10 
                 0.427 
                 2395 
                 0.008 
                 1.08 
                 0.423 
                 3047 
               
               
                 C06 
                 rs2113691 
                 5382731 
                 C 
                 0.485 
                 28112 
                 0.016 
                 1.08 
                 0.505 
                 2339 
                 0.044 
                 1.06 
                 0.500 
                 2987 
               
               
                 C06 
                 rs6459613 
                 10170597 
                 A 
                 0.549 
                 28236 
                 0.039 
                 1.07 
                 0.565 
                 2393 
                 0.044 
                 1.06 
                 0.563 
                 3043 
               
               
                 C06 
                 rs9357002 
                 10958298 
                 T 
                 0.637 
                 27588 
                 0.002 
                 1.11 
                 0.661 
                 2346 
                 0.0021 
                 1.10 
                 0.659 
                 2986 
               
               
                 C06 
                 rs1028716 
                 12338790 
                 T 
                 0.061 
                 28313 
                 0.025 
                 1.16 
                 0.070 
                 2395 
                 0.0065 
                 1.17 
                 0.071 
                 3047 
               
               
                 C06 
                 rs6940891 
                 17345030 
                 C 
                 0.172 
                 28319 
                 0.013 
                 1.11 
                 0.187 
                 2395 
                 0.012 
                 1.10 
                 0.186 
                 3047 
               
               
                 C06 
                 rs6905466 
                 19958854 
                 T 
                 0.332 
                 28315 
                 0.0027 
                 1.11 
                 0.355 
                 2395 
                 0.0058 
                 1.09 
                 0.351 
                 3047 
               
               
                 C06 
                 rs2294809 
                 20707867 
                 G 
                 0.800 
                 28290 
                 0.027 
                 1.10 
                 0.814 
                 2394 
                 0.053 
                 1.08 
                 0.811 
                 3046 
               
               
                 C06 
                 rs9393558 
                 24562175 
                 T 
                 0.347 
                 28292 
                 0.0028 
                 1.11 
                 0.370 
                 2395 
                 0.046 
                 1.06 
                 0.361 
                 3046 
               
               
                 C06 
                 rs722086 
                 25536933 
                 T 
                 0.860 
                 27686 
                 0.0019 
                 1.16 
                 0.877 
                 2373 
                 0.0099 
                 1.12 
                 0.873 
                 3018 
               
               
                 C06 
                 rs9461366 
                 27418512 
                 G 
                 0.614 
                 28267 
                 0.011 
                 1.09 
                 0.634 
                 2392 
                 0.1 
                 1.05 
                 0.626 
                 3043 
               
               
                 C06 
                 rs149951 
                 28141066 
                 T 
                 0.726 
                 28316 
                 0.006 
                 1.11 
                 0.745 
                 2395 
                 0.13 
                 1.05 
                 0.735 
                 3047 
               
               
                 C06 
                 rs203877 
                 28156603 
                 T 
                 0.729 
                 27802 
                 0.0058 
                 1.11 
                 0.749 
                 2347 
                 0.1 
                 1.06 
                 0.740 
                 2978 
               
               
                 C06 
                 rs1635 
                 28335583 
                 G 
                 0.940 
                 28201 
                 0.00018 
                 1.32 
                 0.954 
                 2382 
                 0.00032 
                 1.27 
                 0.952 
                 3031 
               
               
                 C06 
                 rs2074464 
                 29516507 
                 T 
                 0.446 
                 28296 
                 0.0015 
                 1.11 
                 0.471 
                 2392 
                 0.006 
                 1.08 
                 0.466 
                 3044 
               
               
                 C06 
                 rs2107191 
                 29542274 
                 G 
                 0.439 
                 28311 
                 0.00083 
                 1.12 
                 0.466 
                 2394 
                 0.0033 
                 1.09 
                 0.460 
                 3046 
               
               
                 C06 
                 rs1345227 
                 29574935 
                 G 
                 0.376 
                 28036 
                 0.00079 
                 1.12 
                 0.402 
                 2385 
                 0.0011 
                 1.10 
                 0.399 
                 3032 
               
               
                 C06 
                 rs3094572 
                 29588972 
                 A 
                 0.385 
                 28320 
                 0.0012 
                 1.11 
                 0.410 
                 2395 
                 0.0021 
                 1.10 
                 0.407 
                 3047 
               
               
                 C06 
                 rs3094564 
                 29594324 
                 G 
                 0.384 
                 28318 
                 0.00099 
                 1.12 
                 0.410 
                 2395 
                 0.0017 
                 1.10 
                 0.407 
                 3047 
               
               
                 C06 
                 rs166327 
                 30110860 
                 A 
                 0.601 
                 28296 
                 0.00011 
                 1.14 
                 0.631 
                 2395 
                 0.0024 
                 1.10 
                 0.622 
                 3047 
               
               
                 C06 
                 rs1864750 
                 36812785 
                 G 
                 0.253 
                 28236 
                 0.0024 
                 1.12 
                 0.274 
                 2391 
                 0.00097 
                 1.12 
                 0.274 
                 3042 
               
               
                 C06 
                 rs236444 
                 36831682 
                 T 
                 0.257 
                 28318 
                 0.0042 
                 1.11 
                 0.277 
                 2394 
                 0.0019 
                 1.11 
                 0.277 
                 3046 
               
               
                 C06 
                 rs9296225 
                 37622439 
                 C 
                 0.478 
                 28316 
                 0.078 
                 1.06 
                 0.492 
                 2395 
                 0.13 
                 1.05 
                 0.489 
                 3047 
               
               
                 C06 
                 rs9380681 
                 37638433 
                 C 
                 0.311 
                 28318 
                 0.038 
                 1.08 
                 0.327 
                 2395 
                 0.25 
                 1.04 
                 0.319 
                 3047 
               
               
                 C06 
                 rs9296304 
                 39854857 
                 A 
                 0.500 
                 28315 
                 0.022 
                 1.08 
                 0.519 
                 2395 
                 0.03 
                 1.07 
                 0.516 
                 3047 
               
               
                 C06 
                 rs9471170 
                 39888226 
                 G 
                 0.887 
                 28320 
                 0.0047 
                 1.16 
                 0.901 
                 2395 
                 0.061 
                 1.09 
                 0.896 
                 3047 
               
               
                 C06 
                 rs713383 
                 42348347 
                 G 
                 0.684 
                 28317 
                 0.00018 
                 1.14 
                 0.712 
                 2395 
                 0.0011 
                 1.11 
                 0.706 
                 3047 
               
               
                 C06 
                 rs7756421 
                 57141968 
                 A 
                 0.851 
                 28291 
                 0.011 
                 1.13 
                 0.865 
                 2394 
                 0.017 
                 1.11 
                 0.863 
                 3046 
               
               
                 C06 
                 rs1565487 
                 69237128 
                 A 
                 0.860 
                 28266 
                 0.0024 
                 1.16 
                 0.877 
                 2395 
                 0.0025 
                 1.14 
                 0.875 
                 3045 
               
               
                 C06 
                 rs9454539 
                 69273869 
                 A 
                 0.880 
                 28293 
                 0.0025 
                 1.17 
                 0.895 
                 2394 
                 0.0022 
                 1.16 
                 0.894 
                 3046 
               
               
                 C06 
                 rs10806602 
                 69291821 
                 T 
                 0.877 
                 11393 
                 0.0019 
                 1.21 
                 0.896 
                 1771 
                 0.0011 
                 1.21 
                 0.896 
                 2090 
               
               
                 C06 
                 rs7753765 
                 71732495 
                 A 
                 0.144 
                 28312 
                 0.00014 
                 1.19 
                 0.166 
                 2395 
                 0.000047 
                 1.18 
                 0.165 
                 3047 
               
               
                 C06 
                 rs9360453 
                 72211053 
                 G 
                 0.710 
                 11391 
                 0.00044 
                 1.17 
                 0.741 
                 1772 
                 0.00034 
                 1.16 
                 0.739 
                 2090 
               
               
                 C06 
                 rs182106 
                 72270027 
                 T 
                 0.521 
                 28315 
                 0.000019 
                 1.15 
                 0.556 
                 2394 
                 0.000015 
                 1.14 
                 0.553 
                 3046 
               
               
                 C06 
                 rs199623 
                 72270621 
                 A 
                 0.521 
                 28319 
                 0.000024 
                 1.15 
                 0.555 
                 2394 
                 0.000019 
                 1.13 
                 0.552 
                 3046 
               
               
                 C06 
                 rs12207816 
                 72336597 
                 A 
                 0.915 
                 28321 
                 0.0014 
                 1.22 
                 0.929 
                 2395 
                 0.0013 
                 1.20 
                 0.928 
                 3047 
               
               
                 C06 
                 rs10943606 
                 79718496 
                 G 
                 0.748 
                 28313 
                 0.00034 
                 1.15 
                 0.773 
                 2395 
                 0.00041 
                 1.13 
                 0.770 
                 3046 
               
               
                 C06 
                 rs1338023 
                 79785047 
                 T 
                 0.622 
                 28072 
                 0.00013 
                 1.14 
                 0.653 
                 2337 
                 0.00019 
                 1.12 
                 0.649 
                 2984 
               
               
                 C06 
                 rs9352688 
                 79832882 
                 A 
                 0.623 
                 27921 
                 0.000091 
                 1.14 
                 0.654 
                 2347 
                 0.000086 
                 1.13 
                 0.651 
                 2991 
               
               
                 C06 
                 rs6454860 
                 92261323 
                 G 
                 0.327 
                 27828 
                 0.00016 
                 1.14 
                 0.357 
                 2331 
                 0.00098 
                 1.11 
                 0.350 
                 2979 
               
               
                 C06 
                 rs9373729 
                 104320935 
                 G 
                 0.356 
                 28116 
                 0.00046 
                 1.13 
                 0.383 
                 2392 
                 0.00082 
                 1.11 
                 0.380 
                 3041 
               
               
                 C06 
                 rs1149305 
                 105852507 
                 T 
                 0.062 
                 28237 
                 0.092 
                 1.12 
                 0.068 
                 2388 
                 0.18 
                 1.08 
                 0.066 
                 3038 
               
               
                 C06 
                 rs845851 
                 106254239 
                 A 
                 0.769 
                 28278 
                 0.0014 
                 1.14 
                 0.791 
                 2395 
                 0.0067 
                 1.10 
                 0.786 
                 3047 
               
               
                 C06 
                 rs4946680 
                 106265726 
                 T 
                 0.638 
                 28315 
                 0.00093 
                 1.12 
                 0.663 
                 2395 
                 0.007 
                 1.09 
                 0.657 
                 3047 
               
               
                 C06 
                 rs4440505 
                 106293118 
                 C 
                 0.786 
                 28320 
                 0.0094 
                 1.11 
                 0.803 
                 2394 
                 0.047 
                 1.08 
                 0.797 
                 3046 
               
               
                 C06 
                 rs4945955 
                 113999876 
                 T 
                 0.096 
                 28209 
                 0.0016 
                 1.18 
                 0.112 
                 2388 
                 0.00014 
                 1.20 
                 0.113 
                 3039 
               
               
                 C06 
                 rs1360782 
                 119475713 
                 A 
                 0.351 
                 27923 
                 0.028 
                 1.08 
                 0.368 
                 2381 
                 0.0084 
                 1.09 
                 0.369 
                 3029 
               
               
                 C06 
                 rs9388117 
                 123058137 
                 A 
                 0.676 
                 28260 
                 0.015 
                 1.09 
                 0.695 
                 2394 
                 0.029 
                 1.07 
                 0.691 
                 3045 
               
               
                 C06 
                 rs11154416 
                 127903550 
                 G 
                 0.759 
                 28194 
                 0.00041 
                 1.15 
                 0.783 
                 2379 
                 0.0043 
                 1.11 
                 0.776 
                 3028 
               
               
                 C06 
                 rs376632 
                 130100763 
                 G 
                 0.891 
                 28306 
                 0.019 
                 1.13 
                 0.902 
                 2394 
                 0.14 
                 1.07 
                 0.898 
                 3046 
               
               
                 C06 
                 rs9376173 
                 136401139 
                 A 
                 0.636 
                 28291 
                 0.063 
                 1.07 
                 0.651 
                 2386 
                 0.15 
                 1.05 
                 0.646 
                 3038 
               
               
                 C06 
                 rs478884 
                 143072921 
                 A 
                 0.878 
                 28308 
                 0.0091 
                 1.14 
                 0.892 
                 2395 
                 0.0037 
                 1.14 
                 0.892 
                 3046 
               
               
                 C06 
                 rs6570956 
                 149604532 
                 T 
                 0.736 
                 28313 
                 0.0054 
                 1.11 
                 0.756 
                 2395 
                 0.006 
                 1.10 
                 0.754 
                 3047 
               
               
                 C06 
                 rs4512236 
                 156341799 
                 T 
                 0.421 
                 28311 
                 0.027 
                 1.08 
                 0.439 
                 2395 
                 0.11 
                 1.05 
                 0.433 
                 3047 
               
               
                 C06 
                 rs16900254 
                 157876267 
                 A 
                 0.408 
                 11415 
                 0.0076 
                 1.11 
                 0.434 
                 1775 
                 0.013 
                 1.10 
                 0.430 
                 2094 
               
               
                 C06 
                 rs2758317 
                 159987277 
                 C 
                 0.427 
                 28017 
                 0.00011 
                 1.14 
                 0.458 
                 2380 
                 0.002 
                 1.10 
                 0.450 
                 3028 
               
               
                 C06 
                 rs11751605 
                 160883220 
                 C 
                 0.111 
                 28085 
                 0.00098 
                 1.18 
                 0.128 
                 2387 
                 0.00039 
                 1.17 
                 0.128 
                 3033 
               
               
                 C06 
                 rs7739802 
                 162154323 
                 T 
                 0.493 
                 28266 
                 0.027 
                 1.08 
                 0.511 
                 2393 
                 0.011 
                 1.08 
                 0.512 
                 3043 
               
               
                 C06 
                 rs3016536 
                 162157939 
                 G 
                 0.519 
                 28320 
                 0.02 
                 1.08 
                 0.538 
                 2395 
                 0.013 
                 1.08 
                 0.537 
                 3047 
               
               
                 C06 
                 rs875785 
                 162250622 
                 C 
                 0.917 
                 28294 
                 0.0013 
                 1.22 
                 0.931 
                 2391 
                 0.00067 
                 1.21 
                 0.931 
                 3043 
               
               
                 C06 
                 rs1744503 
                 165554293 
                 T 
                 0.487 
                 28235 
                 0.053 
                 1.07 
                 0.503 
                 2391 
                 0.02 
                 1.07 
                 0.504 
                 3040 
               
               
                 C06 
                 rs9348022 
                 165948264 
                 T 
                 0.659 
                 28165 
                 0.022 
                 1.08 
                 0.677 
                 2385 
                 0.064 
                 1.06 
                 0.672 
                 3032 
               
               
                 C07 
                 rs10267593 
                 1903787 
                 G 
                 0.837 
                 28151 
                 0.0063 
                 1.13 
                 0.853 
                 2387 
                 0.00087 
                 1.15 
                 0.854 
                 3036 
               
               
                 C07 
                 rs12234501 
                 8738675 
                 T 
                 0.137 
                 28284 
                 0.012 
                 1.12 
                 0.151 
                 2394 
                 0.002 
                 1.14 
                 0.153 
                 3046 
               
               
                 C07 
                 rs917038 
                 8839252 
                 C 
                 0.787 
                 28193 
                 0.029 
                 1.09 
                 0.801 
                 2380 
                 0.045 
                 1.08 
                 0.799 
                 3030 
               
               
                 C07 
                 rs1526543 
                 11723301 
                 T 
                 0.831 
                 28317 
                 0.0026 
                 1.14 
                 0.849 
                 2395 
                 0.0031 
                 1.13 
                 0.847 
                 3047 
               
               
                 C07 
                 rs6460851 
                 11868337 
                 G 
                 0.290 
                 28289 
                 0.0013 
                 1.12 
                 0.314 
                 2393 
                 0.0013 
                 1.11 
                 0.312 
                 3043 
               
               
                 C07 
                 rs10215881 
                 11880480 
                 C 
                 0.500 
                 28305 
                 0.0087 
                 1.09 
                 0.521 
                 2394 
                 0.02 
                 1.07 
                 0.517 
                 3045 
               
               
                 C07 
                 rs2355129 
                 11892064 
                 A 
                 0.366 
                 28317 
                 0.0049 
                 1.10 
                 0.388 
                 2394 
                 0.004 
                 1.09 
                 0.386 
                 3046 
               
               
                 C07 
                 rs3735344 
                 13901213 
                 G 
                 0.422 
                 28199 
                 0.007 
                 1.09 
                 0.443 
                 2379 
                 0.007 
                 1.08 
                 0.441 
                 3030 
               
               
                 C07 
                 rs706076 
                 16813149 
                 G 
                 0.145 
                 28302 
                 0.0057 
                 1.13 
                 0.161 
                 2394 
                 0.073 
                 1.08 
                 0.154 
                 3046 
               
               
                 C07 
                 rs1029577 
                 17032434 
                 T 
                 0.318 
                 28274 
                 0.00028 
                 1.13 
                 0.346 
                 2391 
                 0.0015 
                 1.10 
                 0.340 
                 3043 
               
               
                 C07 
                 rs11766489 
                 17970195 
                 T 
                 0.427 
                 28308 
                 0.013 
                 1.08 
                 0.447 
                 2394 
                 0.015 
                 1.08 
                 0.445 
                 3045 
               
               
                 C07 
                 rs4470902 
                 17974835 
                 C 
                 0.423 
                 28315 
                 0.008 
                 1.09 
                 0.444 
                 2395 
                 0.011 
                 1.08 
                 0.441 
                 3047 
               
               
                 C07 
                 rs2269752 
                 18665810 
                 C 
                 0.930 
                 28307 
                 0.0068 
                 1.20 
                 0.941 
                 2395 
                 0.011 
                 1.17 
                 0.939 
                 3047 
               
               
                 C07 
                 rs10486378 
                 19952661 
                 G 
                 0.279 
                 28001 
                 0.048 
                 1.07 
                 0.294 
                 2365 
                 0.15 
                 1.05 
                 0.289 
                 3011 
               
               
                 C07 
                 rs2110007 
                 21159866 
                 C 
                 0.942 
                 28252 
                 0.00095 
                 1.28 
                 0.954 
                 2390 
                 0.0036 
                 1.21 
                 0.952 
                 3038 
               
               
                 C07 
                 rs4722054 
                 21773017 
                 G 
                 0.088 
                 28234 
                 0.012 
                 1.15 
                 0.100 
                 2373 
                 0.052 
                 1.10 
                 0.097 
                 3024 
               
               
                 C07 
                 rs1174943 
                 21973643 
                 G 
                 0.159 
                 28309 
                 0.0049 
                 1.13 
                 0.176 
                 2394 
                 0.025 
                 1.09 
                 0.171 
                 3046 
               
               
                 C07 
                 rs17146355 
                 22181251 
                 A 
                 0.050 
                 28301 
                 0.039 
                 1.16 
                 0.057 
                 2392 
                 0.02 
                 1.16 
                 0.058 
                 3044 
               
               
                 C07 
                 rs1542608 
                 23521138 
                 G 
                 0.195 
                 28319 
                 0.003 
                 1.13 
                 0.214 
                 2395 
                 0.013 
                 1.10 
                 0.210 
                 3047 
               
               
                 C07 
                 rs740127 
                 28004900 
                 G 
                 0.598 
                 28316 
                 0.092 
                 1.06 
                 0.612 
                 2394 
                 0.48 
                 1.02 
                 0.603 
                 3046 
               
               
                 C07 
                 rs10225945 
                 28216608 
                 A 
                 0.849 
                 28145 
                 0.026 
                 1.11 
                 0.862 
                 2391 
                 0.096 
                 1.07 
                 0.858 
                 3042 
               
               
                 C07 
                 rs10486588 
                 28561447 
                 G 
                 0.230 
                 28252 
                 0.0091 
                 1.10 
                 0.248 
                 2388 
                 0.016 
                 1.09 
                 0.245 
                 3039 
               
               
                 C07 
                 rs1976489 
                 28576321 
                 G 
                 0.248 
                 28319 
                 0.011 
                 1.10 
                 0.266 
                 2395 
                 0.027 
                 1.08 
                 0.263 
                 3047 
               
               
                 C07 
                 rs1357648 
                 38150571 
                 T 
                 0.322 
                 28233 
                 0.0023 
                 1.11 
                 0.346 
                 2386 
                 0.014 
                 1.08 
                 0.339 
                 3035 
               
               
                 C07 
                 rs1525798 
                 39079105 
                 G 
                 0.306 
                 28287 
                 0.011 
                 1.09 
                 0.325 
                 2395 
                 0.011 
                 1.08 
                 0.324 
                 3046 
               
               
                 C07 
                 rs11763728 
                 39112387 
                 T 
                 0.335 
                 28309 
                 0.016 
                 1.09 
                 0.353 
                 2394 
                 0.063 
                 1.06 
                 0.348 
                 3046 
               
               
                 C07 
                 rs4478468 
                 39208006 
                 G 
                 0.312 
                 28300 
                 0.013 
                 1.09 
                 0.331 
                 2395 
                 0.037 
                 1.07 
                 0.326 
                 3047 
               
               
                 C07 
                 rs3757564 
                 43169187 
                 C 
                 0.072 
                 28304 
                 0.06 
                 1.12 
                 0.080 
                 2391 
                 0.065 
                 1.11 
                 0.079 
                 3042 
               
               
                 C07 
                 rs10243723 
                 46499109 
                 G 
                 0.972 
                 28311 
                 0.018 
                 1.29 
                 0.978 
                 2394 
                 0.045 
                 1.21 
                 0.977 
                 3046 
               
               
                 C07 
                 rs956010 
                 46744540 
                 A 
                 0.883 
                 28321 
                 0.0085 
                 1.15 
                 0.896 
                 2395 
                 0.00084 
                 1.17 
                 0.898 
                 3047 
               
               
                 C07 
                 rs6956126 
                 46756987 
                 G 
                 0.888 
                 28318 
                 0.019 
                 1.13 
                 0.900 
                 2395 
                 0.0026 
                 1.16 
                 0.902 
                 3047 
               
               
                 C07 
                 rs13240380 
                 49733144 
                 T 
                 0.436 
                 28313 
                 0.14 
                 1.05 
                 0.448 
                 2395 
                 0.1 
                 1.05 
                 0.448 
                 3046 
               
               
                 C07 
                 rs12669163 
                 50249131 
                 C 
                 0.300 
                 27988 
                 0.0062 
                 1.10 
                 0.320 
                 2367 
                 0.028 
                 1.07 
                 0.315 
                 3015 
               
               
                 C07 
                 rs17134122 
                 51042598 
                 A 
                 0.967 
                 28320 
                 0.093 
                 1.17 
                 0.972 
                 2395 
                 0.11 
                 1.15 
                 0.971 
                 3047 
               
               
                 C07 
                 rs4527771 
                 67522223 
                 A 
                 0.406 
                 28212 
                 0.00063 
                 1.12 
                 0.433 
                 2385 
                 0.016 
                 1.07 
                 0.423 
                 3034 
               
               
                 C07 
                 rs12540706 
                 67550019 
                 G 
                 0.313 
                 28310 
                 0.000047 
                 1.15 
                 0.344 
                 2394 
                 0.0011 
                 1.11 
                 0.335 
                 3046 
               
               
                 C07 
                 rs7787362 
                 73030539 
                 C 
                 0.562 
                 28182 
                 0.0075 
                 1.09 
                 0.583 
                 2389 
                 0.012 
                 1.08 
                 0.580 
                 3038 
               
               
                 C07 
                 rs2192658 
                 78023891 
                 T 
                 0.078 
                 28313 
                 0.032 
                 1.13 
                 0.088 
                 2394 
                 0.02 
                 1.13 
                 0.087 
                 3045 
               
               
                 C07 
                 rs6467882 
                 81513097 
                 C 
                 0.168 
                 28308 
                 0.024 
                 1.10 
                 0.182 
                 2395 
                 0.03 
                 1.09 
                 0.180 
                 3045 
               
               
                 C07 
                 rs2373018 
                 85426196 
                 G 
                 0.371 
                 28312 
                 0.015 
                 1.09 
                 0.391 
                 2395 
                 0.0087 
                 1.08 
                 0.390 
                 3045 
               
               
                 C07 
                 rs10276025 
                 85428427 
                 T 
                 0.371 
                 28319 
                 0.014 
                 1.09 
                 0.391 
                 2395 
                 0.0084 
                 1.08 
                 0.390 
                 3047 
               
               
                 C07 
                 rs1012995 
                 85495735 
                 C 
                 0.218 
                 28145 
                 0.029 
                 1.09 
                 0.233 
                 2375 
                 0.024 
                 1.08 
                 0.232 
                 3022 
               
               
                 C07 
                 rs2373593 
                 86874878 
                 A 
                 0.864 
                 28311 
                 0.0018 
                 1.17 
                 0.881 
                 2395 
                 0.0026 
                 1.14 
                 0.879 
                 3047 
               
               
                 C07 
                 rs31662 
                 86883520 
                 G 
                 0.864 
                 28315 
                 0.0018 
                 1.17 
                 0.881 
                 2395 
                 0.0021 
                 1.15 
                 0.879 
                 3047 
               
               
                 C07 
                 rs999885 
                 99539112 
                 T 
                 0.505 
                 27962 
                 0.02 
                 1.08 
                 0.524 
                 2351 
                 0.033 
                 1.07 
                 0.521 
                 2997 
               
               
                 C07 
                 rs7804867 
                 102820993 
                 A 
                 0.208 
                 28315 
                 0.056 
                 1.08 
                 0.221 
                 2395 
                 0.16 
                 1.05 
                 0.216 
                 3046 
               
               
                 C07 
                 rs2270019 
                 102844244 
                 G 
                 0.168 
                 28300 
                 0.0047 
                 1.13 
                 0.186 
                 2392 
                 0.012 
                 1.10 
                 0.182 
                 3044 
               
               
                 C07 
                 rs17152161 
                 102928939 
                 C 
                 0.158 
                 28304 
                 0.002 
                 1.14 
                 0.177 
                 2395 
                 0.00069 
                 1.14 
                 0.177 
                 3047 
               
               
                 C07 
                 rs10282605 
                 102949606 
                 C 
                 0.188 
                 28303 
                 0.00052 
                 1.15 
                 0.210 
                 2395 
                 0.00081 
                 1.13 
                 0.208 
                 3047 
               
               
                 C07 
                 rs1029396 
                 116812056 
                 G 
                 0.071 
                 28315 
                 0.0018 
                 1.21 
                 0.084 
                 2395 
                 0.000061 
                 1.24 
                 0.086 
                 3047 
               
               
                 C07 
                 rs2283054 
                 116913637 
                 A 
                 0.070 
                 28319 
                 0.0022 
                 1.20 
                 0.083 
                 2394 
                 0.000086 
                 1.24 
                 0.086 
                 3046 
               
               
                 C07 
                 rs2237721 
                 116920956 
                 C 
                 0.070 
                 28314 
                 0.0022 
                 1.20 
                 0.083 
                 2395 
                 0.000088 
                 1.24 
                 0.085 
                 3047 
               
               
                 C07 
                 rs10487368 
                 116927331 
                 T 
                 0.194 
                 28319 
                 0.034 
                 1.09 
                 0.208 
                 2395 
                 0.0033 
                 1.11 
                 0.212 
                 3047 
               
               
                 C07 
                 rs2237723 
                 116934783 
                 T 
                 0.197 
                 28304 
                 0.032 
                 1.09 
                 0.211 
                 2395 
                 0.0031 
                 1.11 
                 0.215 
                 3047 
               
               
                 C07 
                 rs2237724 
                 116941395 
                 A 
                 0.194 
                 28320 
                 0.034 
                 1.09 
                 0.208 
                 2395 
                 0.0033 
                 1.11 
                 0.212 
                 3047 
               
               
                 C07 
                 rs2027945 
                 116975058 
                 A 
                 0.194 
                 28316 
                 0.032 
                 1.09 
                 0.208 
                 2395 
                 0.0031 
                 1.11 
                 0.212 
                 3047 
               
               
                 C07 
                 rs213977 
                 117025681 
                 G 
                 0.412 
                 28316 
                 0.002 
                 1.11 
                 0.437 
                 2395 
                 0.00051 
                 1.11 
                 0.438 
                 3047 
               
               
                 C07 
                 rs2299445 
                 117033551 
                 C 
                 0.080 
                 28315 
                 0.00061 
                 1.21 
                 0.096 
                 2394 
                 0.000033 
                 1.24 
                 0.098 
                 3046 
               
               
                 C07 
                 rs213987 
                 117048529 
                 T 
                 0.328 
                 28300 
                 0.0036 
                 1.11 
                 0.351 
                 2395 
                 0.0017 
                 1.10 
                 0.350 
                 3046 
               
               
                 C07 
                 rs12534186 
                 117079572 
                 T 
                 0.081 
                 28310 
                 0.00056 
                 1.22 
                 0.096 
                 2394 
                 0.00003 
                 1.24 
                 0.098 
                 3046 
               
               
                 C07 
                 rs975722 
                 117120150 
                 G 
                 0.392 
                 28318 
                 0.0044 
                 1.10 
                 0.414 
                 2395 
                 0.0009 
                 1.11 
                 0.415 
                 3047 
               
               
                 C07 
                 rs324594 
                 136305863 
                 C 
                 0.266 
                 28310 
                 0.0023 
                 1.12 
                 0.289 
                 2395 
                 0.0018 
                 1.11 
                 0.287 
                 3047 
               
               
                 C07 
                 rs11761344 
                 136433359 
                 T 
                 0.119 
                 28295 
                 0.0042 
                 1.15 
                 0.134 
                 2393 
                 0.0046 
                 1.13 
                 0.132 
                 3045 
               
               
                 C07 
                 rs7791708 
                 144537777 
                 A 
                 0.677 
                 28231 
                 0.0046 
                 1.11 
                 0.698 
                 2387 
                 0.013 
                 1.08 
                 0.694 
                 3035 
               
               
                 C07 
                 rs10271435 
                 147385206 
                 A 
                 0.063 
                 28313 
                 0.05 
                 1.14 
                 0.071 
                 2395 
                 0.0065 
                 1.17 
                 0.073 
                 3047 
               
               
                 C07 
                 rs10277774 
                 150219733 
                 C 
                 0.390 
                 28309 
                 0.11 
                 1.06 
                 0.402 
                 2394 
                 0.11 
                 1.05 
                 0.401 
                 3046 
               
               
                 C07 
                 rs11762978 
                 150241033 
                 A 
                 0.654 
                 28261 
                 0.0057 
                 1.10 
                 0.676 
                 2391 
                 0.0029 
                 1.10 
                 0.675 
                 3043 
               
               
                 C07 
                 rs2373885 
                 150309013 
                 A 
                 0.749 
                 28303 
                 0.014 
                 1.10 
                 0.766 
                 2395 
                 0.013 
                 1.09 
                 0.765 
                 3046 
               
               
                 C07 
                 rs11769878 
                 157343230 
                 C 
                 0.741 
                 27759 
                 0.0011 
                 1.13 
                 0.764 
                 2355 
                 0.0054 
                 1.10 
                 0.759 
                 2996 
               
               
                 C08 
                 rs722782 
                 506479 
                 C 
                 0.892 
                 28261 
                 0.011 
                 1.15 
                 0.904 
                 2363 
                 0.026 
                 1.12 
                 0.902 
                 3014 
               
               
                 C08 
                 rs7386449 
                 1315247 
                 A 
                 0.681 
                 28312 
                 0.0066 
                 1.10 
                 0.701 
                 2395 
                 0.0044 
                 1.10 
                 0.700 
                 3046 
               
               
                 C08 
                 rs10503316 
                 5498753 
                 C 
                 0.776 
                 28318 
                 0.022 
                 1.10 
                 0.792 
                 2395 
                 0.058 
                 1.07 
                 0.788 
                 3047 
               
               
                 C08 
                 rs6991017 
                 5508780 
                 T 
                 0.793 
                 28273 
                 0.013 
                 1.11 
                 0.809 
                 2393 
                 0.044 
                 1.08 
                 0.805 
                 3044 
               
               
                 C08 
                 rs890014 
                 5835084 
                 C 
                 0.762 
                 28320 
                 0.15 
                 1.06 
                 0.772 
                 2395 
                 0.25 
                 1.04 
                 0.769 
                 3047 
               
               
                 C08 
                 rs7006687 
                 18277862 
                 T 
                 0.579 
                 28306 
                 0.0018 
                 1.11 
                 0.604 
                 2392 
                 0.00068 
                 1.11 
                 0.604 
                 3044 
               
               
                 C08 
                 rs334198 
                 18933089 
                 C 
                 0.922 
                 28309 
                 0.037 
                 0.89 
                 0.913 
                 2393 
                 0.082 
                 0.91 
                 0.915 
                 3045 
               
               
                 C08 
                 rs11775256 
                 23107430 
                 T 
                 0.274 
                 28317 
                 0.048 
                 1.07 
                 0.288 
                 2395 
                 0.029 
                 1.07 
                 0.288 
                 3047 
               
               
                 C08 
                 rs4732849 
                 28249765 
                 T 
                 0.275 
                 28321 
                 0.0069 
                 1.10 
                 0.295 
                 2395 
                 0.13 
                 1.05 
                 0.285 
                 3047 
               
               
                 C08 
                 rs904053 
                 28258855 
                 G 
                 0.224 
                 28313 
                 0.035 
                 1.08 
                 0.238 
                 2395 
                 0.43 
                 1.03 
                 0.229 
                 3047 
               
               
                 C08 
                 rs12547858 
                 32606595 
                 T 
                 0.193 
                 28139 
                 0.0023 
                 1.13 
                 0.213 
                 2382 
                 0.0065 
                 1.11 
                 0.209 
                 3025 
               
               
                 C08 
                 rs10503927 
                 32662772 
                 T 
                 0.476 
                 28318 
                 0.0011 
                 1.11 
                 0.503 
                 2395 
                 0.00025 
                 1.11 
                 0.503 
                 3047 
               
               
                 C08 
                 rs9656744 
                 32836025 
                 T 
                 0.509 
                 28311 
                 0.0033 
                 1.10 
                 0.533 
                 2394 
                 0.01 
                 1.08 
                 0.528 
                 3044 
               
               
                 C08 
                 rs16880128 
                 32852935 
                 G 
                 0.441 
                 27756 
                 0.0014 
                 1.11 
                 0.467 
                 2362 
                 0.014 
                 1.08 
                 0.459 
                 3002 
               
               
                 C08 
                 rs7017907 
                 37527288 
                 C 
                 0.088 
                 28266 
                 0.15 
                 1.08 
                 0.095 
                 2385 
                 0.86 
                 1.01 
                 0.089 
                 3037 
               
               
                 C08 
                 rs7830101 
                 39527585 
                 T 
                 0.278 
                 28099 
                 0.071 
                 1.07 
                 0.291 
                 2372 
                 0.027 
                 1.08 
                 0.292 
                 3021 
               
               
                 C08 
                 rs7819949 
                 41507078 
                 T 
                 0.274 
                 28315 
                 0.038 
                 1.08 
                 0.289 
                 2395 
                 0.32 
                 1.03 
                 0.281 
                 3047 
               
               
                 C08 
                 rs7010934 
                 59139573 
                 C 
                 0.843 
                 28316 
                 0.0004 
                 1.18 
                 0.864 
                 2395 
                 0.01 
                 1.11 
                 0.857 
                 3047 
               
               
                 C08 
                 rs4738034 
                 70924464 
                 C 
                 0.703 
                 28321 
                 0.0094 
                 1.10 
                 0.723 
                 2395 
                 0.016 
                 1.08 
                 0.720 
                 3047 
               
               
                 C08 
                 rs3829049 
                 70925162 
                 G 
                 0.710 
                 28294 
                 0.006 
                 1.11 
                 0.730 
                 2393 
                 0.011 
                 1.09 
                 0.727 
                 3045 
               
               
                 C08 
                 rs7015359 
                 70957101 
                 G 
                 0.186 
                 28320 
                 0.0028 
                 1.13 
                 0.205 
                 2395 
                 0.0083 
                 1.10 
                 0.201 
                 3047 
               
               
                 C08 
                 rs10504537 
                 73402234 
                 A 
                 0.881 
                 28213 
                 0.035 
                 1.12 
                 0.891 
                 2387 
                 0.027 
                 1.11 
                 0.891 
                 3035 
               
               
                 C08 
                 rs1837544 
                 73839615 
                 G 
                 0.243 
                 28305 
                 0.03 
                 1.09 
                 0.259 
                 2395 
                 0.15 
                 1.05 
                 0.253 
                 3046 
               
               
                 C08 
                 rs10504576 
                 75429234 
                 A 
                 0.482 
                 28062 
                 0.0036 
                 1.10 
                 0.506 
                 2370 
                 0.0083 
                 1.08 
                 0.502 
                 3018 
               
               
                 C08 
                 rs4410896 
                 75433049 
                 A 
                 0.484 
                 28320 
                 0.0045 
                 1.10 
                 0.507 
                 2395 
                 0.011 
                 1.08 
                 0.503 
                 3047 
               
               
                 C08 
                 rs6996971 
                 75455047 
                 C 
                 0.481 
                 28218 
                 0.0056 
                 1.09 
                 0.504 
                 2388 
                 0.012 
                 1.08 
                 0.500 
                 3037 
               
               
                 C08 
                 rs10283076 
                 75470386 
                 G 
                 0.482 
                 28290 
                 0.0045 
                 1.10 
                 0.505 
                 2392 
                 0.0087 
                 1.08 
                 0.501 
                 3043 
               
               
                 C08 
                 rs2369121 
                 79361197 
                 T 
                 0.720 
                 28319 
                 0.004 
                 1.11 
                 0.741 
                 2395 
                 0.0061 
                 1.10 
                 0.738 
                 3047 
               
               
                 C08 
                 rs2607102 
                 92586353 
                 T 
                 0.926 
                 28218 
                 0.0015 
                 1.23 
                 0.939 
                 2380 
                 0.0088 
                 1.17 
                 0.936 
                 3028 
               
               
                 C08 
                 rs3102526 
                 96858538 
                 G 
                 0.647 
                 27995 
                 0.013 
                 1.09 
                 0.666 
                 2382 
                 0.015 
                 1.08 
                 0.664 
                 3019 
               
               
                 C08 
                 rs3134517 
                 96859237 
                 G 
                 0.647 
                 28308 
                 0.016 
                 1.09 
                 0.666 
                 2395 
                 0.018 
                 1.08 
                 0.664 
                 3047 
               
               
                 C08 
                 rs2440213 
                 97275495 
                 A 
                 0.360 
                 28316 
                 0.0016 
                 1.11 
                 0.385 
                 2395 
                 0.0078 
                 1.09 
                 0.379 
                 3047 
               
               
                 C08 
                 rs1992087 
                 97552943 
                 G 
                 0.261 
                 28309 
                 0.019 
                 1.09 
                 0.278 
                 2394 
                 0.028 
                 1.08 
                 0.276 
                 3046 
               
               
                 C08 
                 rs1075479 
                 97849402 
                 A 
                 0.792 
                 28280 
                 0.017 
                 1.10 
                 0.808 
                 2390 
                 0.075 
                 1.07 
                 0.803 
                 3039 
               
               
                 C08 
                 rs4620270 
                 125506992 
                 T 
                 0.133 
                 28307 
                 0.082 
                 1.09 
                 0.143 
                 2394 
                 0.041 
                 1.09 
                 0.143 
                 3046 
               
               
                 C08 
                 rs2648896 
                 129169615 
                 C 
                 0.149 
                 28304 
                 0.0004 
                 1.17 
                 0.170 
                 2395 
                 0.00052 
                 1.15 
                 0.167 
                 3047 
               
               
                 C08 
                 rs2302793 
                 129177879 
                 G 
                 0.434 
                 28273 
                 0.0018 
                 1.11 
                 0.459 
                 2382 
                 0.0075 
                 1.08 
                 0.454 
                 3033 
               
               
                 C08 
                 rs3931282 
                 129179963 
                 T 
                 0.568 
                 28319 
                 0.0016 
                 0.90 
                 0.543 
                 2395 
                 0.007 
                 0.92 
                 0.548 
                 3047 
               
               
                 C08 
                 rs10505507 
                 129311983 
                 A 
                 0.923 
                 28320 
                 0.000057 
                 1.30 
                 0.939 
                 2395 
                 0.0019 
                 1.20 
                 0.935 
                 3047 
               
               
                 C08 
                 rs4451334 
                 138344030 
                 A 
                 0.064 
                 28282 
                 0.1 
                 1.11 
                 0.071 
                 2390 
                 0.13 
                 1.09 
                 0.070 
                 3042 
               
               
                 C08 
                 rs4909759 
                 139293683 
                 T 
                 0.263 
                 28309 
                 0.051 
                 1.07 
                 0.277 
                 2395 
                 0.013 
                 1.09 
                 0.279 
                 3047 
               
               
                 C08 
                 rs4909761 
                 139294744 
                 T 
                 0.264 
                 28318 
                 0.037 
                 1.08 
                 0.279 
                 2395 
                 0.0088 
                 1.09 
                 0.281 
                 3047 
               
               
                 C08 
                 rs747551 
                 143209084 
                 T 
                 0.433 
                 28310 
                 0.0092 
                 1.09 
                 0.454 
                 2393 
                 0.034 
                 1.07 
                 0.449 
                 3045 
               
               
                 C08 
                 rs7834060 
                 143220109 
                 G 
                 0.431 
                 28316 
                 0.015 
                 1.08 
                 0.450 
                 2395 
                 0.046 
                 1.06 
                 0.445 
                 3047 
               
               
                 C08 
                 rs3934930 
                 143226261 
                 T 
                 0.430 
                 28320 
                 0.014 
                 1.08 
                 0.450 
                 2395 
                 0.043 
                 1.06 
                 0.445 
                 3047 
               
               
                 C08 
                 rs11167132 
                 143245585 
                 T 
                 0.216 
                 28136 
                 0.0076 
                 1.11 
                 0.234 
                 2383 
                 0.031 
                 1.08 
                 0.230 
                 3028 
               
               
                 C08 
                 rs9644545 
                 143276606 
                 T 
                 0.475 
                 28309 
                 0.0002 
                 1.13 
                 0.505 
                 2394 
                 0.0004 
                 1.11 
                 0.501 
                 3046 
               
               
                 C08 
                 rs5297 
                 143952659 
                 C 
                 0.091 
                 28314 
                 0.003 
                 1.18 
                 0.105 
                 2394 
                 0.0072 
                 1.14 
                 0.102 
                 3046 
               
               
                 C08 
                 rs7844961 
                 143999186 
                 T 
                 0.092 
                 28314 
                 0.00094 
                 1.19 
                 0.108 
                 2395 
                 0.0035 
                 1.15 
                 0.105 
                 3047 
               
               
                 C08 
                 rs4977114 
                 144250835 
                 C 
                 0.028 
                 28320 
                 0.014 
                 1.26 
                 0.035 
                 2395 
                 0.039 
                 1.19 
                 0.033 
                 3047 
               
               
                 C09 
                 rs2890795 
                 8437732 
                 T 
                 0.579 
                 28315 
                 0.011 
                 1.09 
                 0.599 
                 2395 
                 0.0031 
                 1.09 
                 0.600 
                 3046 
               
               
                 C09 
                 rs10119236 
                 8506194 
                 A 
                 0.297 
                 28304 
                 0.042 
                 1.07 
                 0.313 
                 2395 
                 0.017 
                 1.08 
                 0.314 
                 3047 
               
               
                 C09 
                 rs10960174 
                 11743695 
                 G 
                 0.614 
                 28312 
                 0.00026 
                 1.13 
                 0.643 
                 2392 
                 0.000093 
                 1.13 
                 0.642 
                 3043 
               
               
                 C09 
                 rs1343705 
                 14600866 
                 G 
                 0.475 
                 28306 
                 0.0019 
                 1.11 
                 0.500 
                 2394 
                 0.0021 
                 1.10 
                 0.498 
                 3046 
               
               
                 C09 
                 rs4961695 
                 16318137 
                 C 
                 0.801 
                 28297 
                 0.00029 
                 1.16 
                 0.824 
                 2392 
                 0.00012 
                 1.16 
                 0.823 
                 3042 
               
               
                 C09 
                 rs1888955 
                 16319537 
                 A 
                 0.740 
                 28315 
                 0.00025 
                 1.15 
                 0.766 
                 2395 
                 0.0003 
                 1.13 
                 0.763 
                 3047 
               
               
                 C09 
                 rs9407756 
                 16321304 
                 G 
                 0.674 
                 28318 
                 0.0021 
                 1.11 
                 0.697 
                 2395 
                 0.013 
                 1.08 
                 0.691 
                 3047 
               
               
                 C09 
                 rs12683609 
                 16324761 
                 A 
                 0.572 
                 28317 
                 0.00017 
                 1.13 
                 0.602 
                 2394 
                 0.00038 
                 1.11 
                 0.598 
                 3046 
               
               
                 C09 
                 rs1329044 
                 23737791 
                 C 
                 0.156 
                 28317 
                 0.0092 
                 1.12 
                 0.172 
                 2395 
                 0.011 
                 1.11 
                 0.170 
                 3047 
               
               
                 C09 
                 rs7038525 
                 23762277 
                 T 
                 0.155 
                 28251 
                 0.0084 
                 1.12 
                 0.171 
                 2393 
                 0.0082 
                 1.11 
                 0.169 
                 3045 
               
               
                 C09 
                 rs1452335 
                 28113402 
                 G 
                 0.720 
                 28196 
                 0.018 
                 1.09 
                 0.737 
                 2385 
                 0.022 
                 1.08 
                 0.735 
                 3036 
               
               
                 C09 
                 rs1452336 
                 28114180 
                 A 
                 0.500 
                 28241 
                 0.013 
                 1.09 
                 0.520 
                 2389 
                 0.0021 
                 1.10 
                 0.523 
                 3040 
               
               
                 C09 
                 rs1452337 
                 28116482 
                 G 
                 0.800 
                 28150 
                 0.047 
                 1.09 
                 0.813 
                 2377 
                 0.078 
                 1.07 
                 0.810 
                 3026 
               
               
                 C09 
                 rs2044961 
                 28154645 
                 G 
                 0.573 
                 28307 
                 0.008 
                 1.09 
                 0.594 
                 2395 
                 0.00083 
                 1.11 
                 0.597 
                 3046 
               
               
                 C09 
                 rs10758186 
                 33091838 
                 G 
                 0.385 
                 28316 
                 0.052 
                 1.07 
                 0.400 
                 2395 
                 0.096 
                 1.05 
                 0.397 
                 3047 
               
               
                 C09 
                 rs943535 
                 72064166 
                 A 
                 0.920 
                 28254 
                 0.01 
                 1.18 
                 0.931 
                 2385 
                 0.0061 
                 1.17 
                 0.931 
                 3034 
               
               
                 C09 
                 rs10867740 
                 83153344 
                 C 
                 0.237 
                 28282 
                 0.0067 
                 1.11 
                 0.256 
                 2394 
                 0.028 
                 1.08 
                 0.251 
                 3046 
               
               
                 C09 
                 rs3211650 
                 91115047 
                 T 
                 0.091 
                 28320 
                 0.00074 
                 1.20 
                 0.107 
                 2394 
                 0.0018 
                 1.17 
                 0.104 
                 3046 
               
               
                 C09 
                 rs3211683 
                 91119689 
                 A 
                 0.090 
                 28319 
                 0.00071 
                 1.20 
                 0.107 
                 2395 
                 0.0019 
                 1.17 
                 0.104 
                 3047 
               
               
                 C09 
                 rs7854755 
                 106902871 
                 A 
                 0.202 
                 28257 
                 0.0036 
                 1.12 
                 0.221 
                 2389 
                 0.008 
                 1.10 
                 0.218 
                 3038 
               
               
                 C09 
                 rs4979085 
                 113970927 
                 T 
                 0.296 
                 28305 
                 0.048 
                 1.07 
                 0.311 
                 2392 
                 0.048 
                 1.07 
                 0.309 
                 3044 
               
               
                 C09 
                 rs2236388 
                 116209121 
                 G 
                 0.901 
                 28319 
                 0.048 
                 1.12 
                 0.910 
                 2395 
                 0.01 
                 1.14 
                 0.912 
                 3047 
               
               
                 C09 
                 rs3780680 
                 125819315 
                 T 
                 0.456 
                 28295 
                 0.021 
                 1.08 
                 0.475 
                 2393 
                 0.037 
                 1.06 
                 0.471 
                 3045 
               
               
                 C09 
                 rs7026302 
                 132818296 
                 G 
                 0.909 
                 28320 
                 0.001 
                 1.22 
                 0.924 
                 2395 
                 0.018 
                 1.13 
                 0.919 
                 3047 
               
               
                 C09 
                 rs4917341 
                 136289075 
                 C 
                 0.479 
                 28257 
                 0.00013 
                 1.13 
                 0.510 
                 2392 
                 0.000018 
                 1.14 
                 0.510 
                 3041 
               
               
                 C09 
                 rs1930788 
                 136303539 
                 C 
                 0.250 
                 28321 
                 0.0022 
                 1.12 
                 0.272 
                 2395 
                 0.0049 
                 1.10 
                 0.268 
                 3047 
               
               
                 C09 
                 rs2297538 
                 138684489 
                 G 
                 0.730 
                 28226 
                 0.0012 
                 1.13 
                 0.753 
                 2395 
                 0.00079 
                 1.12 
                 0.752 
                 3047 
               
               
                 C09 
                 rs2385891 
                 138716241 
                 A 
                 0.547 
                 28259 
                 0.0014 
                 1.11 
                 0.572 
                 2387 
                 0.011 
                 1.08 
                 0.565 
                 3037 
               
               
                 C10 
                 rs12776254 
                 2144862 
                 G 
                 0.171 
                 28314 
                 0.0054 
                 1.12 
                 0.189 
                 2395 
                 0.0048 
                 1.11 
                 0.187 
                 3047 
               
               
                 C10 
                 rs4880711 
                 5217871 
                 C 
                 0.351 
                 27953 
                 0.042 
                 1.07 
                 0.367 
                 2379 
                 0.26 
                 1.04 
                 0.359 
                 3015 
               
               
                 C10 
                 rs7912210 
                 5984421 
                 C 
                 0.963 
                 28273 
                 0.00083 
                 1.37 
                 0.973 
                 2374 
                 0.0009 
                 1.33 
                 0.972 
                 3023 
               
               
                 C10 
                 rs541045 
                 8232155 
                 C 
                 0.429 
                 27990 
                 0.00024 
                 1.13 
                 0.459 
                 2351 
                 0.00032 
                 1.11 
                 0.455 
                 3000 
               
               
                 C10 
                 rs4747760 
                 8313669 
                 G 
                 0.874 
                 28308 
                 0.0098 
                 1.14 
                 0.888 
                 2395 
                 0.019 
                 1.11 
                 0.885 
                 3047 
               
               
                 C10 
                 rs7092384 
                 8340796 
                 C 
                 0.861 
                 28315 
                 0.0091 
                 1.13 
                 0.875 
                 2395 
                 0.011 
                 1.12 
                 0.873 
                 3047 
               
               
                 C10 
                 rs1419294 
                 8347160 
                 T 
                 0.710 
                 28320 
                 0.0036 
                 1.11 
                 0.731 
                 2395 
                 0.0045 
                 1.10 
                 0.728 
                 3047 
               
               
                 C10 
                 rs10508403 
                 10448081 
                 T 
                 0.091 
                 28314 
                 0.0017 
                 1.19 
                 0.106 
                 2395 
                 0.01 
                 1.14 
                 0.102 
                 3047 
               
               
                 C10 
                 rs2138930 
                 15423774 
                 T 
                 0.110 
                 28304 
                 0.0065 
                 1.15 
                 0.124 
                 2395 
                 0.021 
                 1.11 
                 0.120 
                 3046 
               
               
                 C10 
                 rs11596590 
                 15455285 
                 T 
                 0.560 
                 28303 
                 0.02 
                 1.08 
                 0.579 
                 2393 
                 0.072 
                 1.06 
                 0.573 
                 3044 
               
               
                 C10 
                 rs12269612 
                 15475877 
                 T 
                 0.401 
                 28314 
                 0.0078 
                 1.09 
                 0.423 
                 2395 
                 0.024 
                 1.07 
                 0.418 
                 3047 
               
               
                 C10 
                 rs1925819 
                 15492765 
                 T 
                 0.560 
                 28319 
                 0.026 
                 1.08 
                 0.578 
                 2395 
                 0.087 
                 1.05 
                 0.572 
                 3047 
               
               
                 C10 
                 rs1013406 
                 15501576 
                 C 
                 0.562 
                 28307 
                 0.024 
                 1.08 
                 0.580 
                 2392 
                 0.087 
                 1.05 
                 0.575 
                 3044 
               
               
                 C10 
                 rs2184383 
                 16416276 
                 G 
                 0.807 
                 28313 
                 0.0019 
                 1.14 
                 0.827 
                 2395 
                 0.016 
                 1.10 
                 0.821 
                 3047 
               
               
                 C10 
                 rs10828393 
                 23329068 
                 C 
                 0.892 
                 28259 
                 0.0039 
                 1.17 
                 0.906 
                 2392 
                 0.012 
                 1.13 
                 0.903 
                 3043 
               
               
                 C10 
                 rs993352 
                 23347212 
                 G 
                 0.885 
                 28271 
                 0.011 
                 1.14 
                 0.898 
                 2384 
                 0.009 
                 1.13 
                 0.897 
                 3032 
               
               
                 C10 
                 rs7086207 
                 26227683 
                 G 
                 0.408 
                 28303 
                 0.00068 
                 1.12 
                 0.435 
                 2394 
                 0.0019 
                 1.10 
                 0.430 
                 3046 
               
               
                 C10 
                 rs788053 
                 29363574 
                 T 
                 0.747 
                 28203 
                 0.0021 
                 1.12 
                 0.768 
                 2391 
                 0.0029 
                 1.11 
                 0.766 
                 3043 
               
               
                 C10 
                 rs7086224 
                 30857283 
                 A 
                 0.419 
                 28287 
                 0.028 
                 1.08 
                 0.437 
                 2393 
                 0.04 
                 1.06 
                 0.434 
                 3045 
               
               
                 C10 
                 rs2804453 
                 33708138 
                 G 
                 0.110 
                 28256 
                 0.021 
                 1.12 
                 0.122 
                 2392 
                 0.051 
                 1.09 
                 0.119 
                 3043 
               
               
                 C10 
                 rs2279434 
                 45275070 
                 T 
                 0.067 
                 28318 
                 0.0029 
                 1.20 
                 0.080 
                 2395 
                 0.014 
                 1.15 
                 0.076 
                 3047 
               
               
                 C10 
                 rs3793786 
                 50413094 
                 C 
                 0.247 
                 28319 
                 0.3 
                 1.04 
                 0.255 
                 2395 
                 0.79 
                 1.01 
                 0.249 
                 3047 
               
               
                 C10 
                 rs4948410 
                 61786053 
                 A 
                 0.788 
                 28175 
                 0.15 
                 1.06 
                 0.797 
                 2391 
                 0.4 
                 1.03 
                 0.793 
                 3041 
               
               
                 C10 
                 rs990828 
                 66253744 
                 G 
                 0.417 
                 28283 
                 0.014 
                 1.08 
                 0.436 
                 2392 
                 0.021 
                 1.07 
                 0.434 
                 3042 
               
               
                 C10 
                 rs17456902 
                 69554012 
                 G 
                 0.874 
                 28317 
                 0.0021 
                 1.17 
                 0.890 
                 2395 
                 0.00092 
                 1.16 
                 0.889 
                 3047 
               
               
                 C10 
                 rs1865017 
                 78364450 
                 C 
                 0.737 
                 28304 
                 0.0091 
                 1.10 
                 0.755 
                 2395 
                 0.047 
                 1.07 
                 0.749 
                 3047 
               
               
                 C10 
                 rs697171 
                 78886007 
                 G 
                 0.912 
                 28288 
                 0.0084 
                 1.17 
                 0.923 
                 2391 
                 0.023 
                 1.13 
                 0.921 
                 3042 
               
               
                 C10 
                 rs4617529 
                 85064616 
                 G 
                 0.856 
                 28321 
                 0.0034 
                 1.15 
                 0.872 
                 2395 
                 0.0021 
                 1.14 
                 0.872 
                 3047 
               
               
                 C10 
                 rs7921473 
                 85156395 
                 G 
                 0.820 
                 28314 
                 0.0011 
                 1.15 
                 0.840 
                 2395 
                 0.0013 
                 1.13 
                 0.838 
                 3047 
               
               
                 C10 
                 rs10787854 
                 85162315 
                 A 
                 0.835 
                 28318 
                 0.0052 
                 1.13 
                 0.851 
                 2395 
                 0.0028 
                 1.13 
                 0.851 
                 3047 
               
               
                 C10 
                 rs2349157 
                 85169216 
                 G 
                 0.860 
                 28317 
                 0.0089 
                 1.13 
                 0.875 
                 2395 
                 0.014 
                 1.11 
                 0.873 
                 3047 
               
               
                 C10 
                 rs4411234 
                 85211638 
                 C 
                 0.648 
                 28293 
                 0.074 
                 1.06 
                 0.662 
                 2395 
                 0.027 
                 1.07 
                 0.663 
                 3047 
               
               
                 C10 
                 rs10886432 
                 85217844 
                 G 
                 0.648 
                 28271 
                 0.064 
                 1.07 
                 0.662 
                 2394 
                 0.023 
                 1.07 
                 0.663 
                 3046 
               
               
                 C10 
                 rs11198993 
                 85244450 
                 A 
                 0.697 
                 28239 
                 0.022 
                 1.09 
                 0.714 
                 2387 
                 0.0037 
                 1.10 
                 0.717 
                 3038 
               
               
                 C10 
                 rs11199158 
                 85297471 
                 G 
                 0.618 
                 28319 
                 0.024 
                 1.08 
                 0.635 
                 2395 
                 0.0062 
                 1.09 
                 0.637 
                 3047 
               
               
                 C10 
                 rs11199316 
                 85333276 
                 C 
                 0.724 
                 27673 
                 0.037 
                 1.08 
                 0.739 
                 2358 
                 0.03 
                 1.08 
                 0.738 
                 3002 
               
               
                 C10 
                 rs10749535 
                 88094506 
                 T 
                 0.478 
                 28319 
                 0.026 
                 1.08 
                 0.496 
                 2395 
                 0.048 
                 1.06 
                 0.492 
                 3047 
               
               
                 C10 
                 rs4933391 
                 88111974 
                 A 
                 0.393 
                 28298 
                 0.011 
                 1.09 
                 0.413 
                 2395 
                 0.021 
                 1.07 
                 0.409 
                 3047 
               
               
                 C10 
                 rs3814614 
                 88118261 
                 T 
                 0.508 
                 28312 
                 0.013 
                 1.08 
                 0.528 
                 2394 
                 0.013 
                 1.08 
                 0.526 
                 3046 
               
               
                 C10 
                 rs1412444 
                 90992907 
                 A 
                 0.361 
                 28293 
                 0.00037 
                 1.13 
                 0.389 
                 2394 
                 0.0014 
                 1.10 
                 0.383 
                 3045 
               
               
                 C10 
                 rs2243548 
                 91000293 
                 A 
                 0.512 
                 28294 
                 0.0007 
                 1.12 
                 0.540 
                 2392 
                 0.0087 
                 1.08 
                 0.532 
                 3043 
               
               
                 C10 
                 rs2243547 
                 91000459 
                 G 
                 0.331 
                 28033 
                 0.000027 
                 1.15 
                 0.363 
                 2386 
                 0.00066 
                 1.11 
                 0.355 
                 3033 
               
               
                 C10 
                 rs1028935 
                 93339072 
                 A 
                 0.189 
                 28316 
                 0.15 
                 1.06 
                 0.199 
                 2395 
                 0.25 
                 1.04 
                 0.196 
                 3047 
               
               
                 C10 
                 rs10509657 
                 95166923 
                 C 
                 0.103 
                 28305 
                 0.024 
                 1.12 
                 0.115 
                 2395 
                 0.078 
                 1.09 
                 0.111 
                 3047 
               
               
                 C10 
                 rs10509680 
                 96724329 
                 T 
                 0.052 
                 28256 
                 0.064 
                 1.14 
                 0.059 
                 2389 
                 0.17 
                 1.09 
                 0.057 
                 3039 
               
               
                 C10 
                 rs1539089 
                 102211414 
                 C 
                 0.224 
                 28318 
                 0.027 
                 1.09 
                 0.239 
                 2395 
                 0.0086 
                 1.10 
                 0.240 
                 3047 
               
               
                 C10 
                 rs11190578 
                 102228943 
                 T 
                 0.224 
                 28317 
                 0.027 
                 1.09 
                 0.239 
                 2395 
                 0.0085 
                 1.10 
                 0.240 
                 3047 
               
               
                 C10 
                 rs9420802 
                 102341775 
                 G 
                 0.210 
                 11411 
                 0.0064 
                 1.14 
                 0.232 
                 1773 
                 0.0074 
                 1.13 
                 0.230 
                 2092 
               
               
                 C10 
                 rs4630219 
                 102472174 
                 C 
                 0.099 
                 11332 
                 0.008 
                 1.18 
                 0.115 
                 1768 
                 0.012 
                 1.16 
                 0.113 
                 2083 
               
               
                 C10 
                 rs11192557 
                 107442673 
                 T 
                 0.878 
                 28251 
                 0.017 
                 1.13 
                 0.890 
                 2390 
                 0.019 
                 1.11 
                 0.889 
                 3040 
               
               
                 C10 
                 rs1337430 
                 108996443 
                 A 
                 0.796 
                 28310 
                 0.2 
                 1.05 
                 0.804 
                 2392 
                 0.25 
                 1.04 
                 0.803 
                 3044 
               
               
                 C10 
                 rs1557227 
                 119643657 
                 C 
                 0.859 
                 28316 
                 0.0093 
                 1.13 
                 0.873 
                 2394 
                 0.0018 
                 1.15 
                 0.874 
                 3046 
               
               
                 C10 
                 rs7922488 
                 120006858 
                 G 
                 0.536 
                 28291 
                 0.022 
                 1.08 
                 0.554 
                 2385 
                 0.051 
                 1.06 
                 0.550 
                 3037 
               
               
                 C10 
                 rs2935689 
                 123476616 
                 C 
                 0.839 
                 28314 
                 0.00098 
                 1.16 
                 0.858 
                 2395 
                 0.013 
                 1.11 
                 0.852 
                 3047 
               
               
                 C10 
                 rs2936875 
                 123481633 
                 T 
                 0.782 
                 28304 
                 0.00031 
                 1.16 
                 0.806 
                 2394 
                 0.0031 
                 1.11 
                 0.800 
                 3046 
               
               
                 C10 
                 rs2239586 
                 124239225 
                 T 
                 0.119 
                 28306 
                 0.0046 
                 1.15 
                 0.134 
                 2395 
                 0.011 
                 1.12 
                 0.131 
                 3047 
               
               
                 C10 
                 rs639079 
                 132085590 
                 G 
                 0.192 
                 27862 
                 0.00062 
                 1.15 
                 0.214 
                 2354 
                 0.0009 
                 1.13 
                 0.211 
                 2998 
               
               
                 C10 
                 rs11597160 
                 132163778 
                 A 
                 0.907 
                 28320 
                 0.0034 
                 1.19 
                 0.920 
                 2395 
                 0.015 
                 1.14 
                 0.917 
                 3047 
               
               
                 C10 
                 rs1484652 
                 132164140 
                 T 
                 0.906 
                 28319 
                 0.002 
                 1.20 
                 0.920 
                 2395 
                 0.0092 
                 1.15 
                 0.917 
                 3047 
               
               
                 C10 
                 rs893504 
                 132859084 
                 C 
                 0.073 
                 28315 
                 0.021 
                 1.15 
                 0.082 
                 2395 
                 0.0064 
                 1.16 
                 0.083 
                 3047 
               
               
                 C11 
                 rs7122936 
                 1331032 
                 A 
                 0.576 
                 28230 
                 0.00078 
                 1.12 
                 0.603 
                 2395 
                 0.0013 
                 1.10 
                 0.600 
                 3046 
               
               
                 C11 
                 rs7944761 
                 1361414 
                 T 
                 0.532 
                 28309 
                 0.0053 
                 1.10 
                 0.555 
                 2395 
                 0.0027 
                 1.09 
                 0.554 
                 3047 
               
               
                 C11 
                 rs4963076 
                 1379752 
                 T 
                 0.481 
                 28301 
                 0.011 
                 1.09 
                 0.502 
                 2395 
                 0.04 
                 1.06 
                 0.496 
                 3047 
               
               
                 C11 
                 rs11041390 
                 7432565 
                 A 
                 0.730 
                 28304 
                 0.0048 
                 1.11 
                 0.750 
                 2394 
                 0.013 
                 1.09 
                 0.746 
                 3046 
               
               
                 C11 
                 rs7113222 
                 7437034 
                 G 
                 0.740 
                 28315 
                 0.0037 
                 1.12 
                 0.760 
                 2395 
                 0.015 
                 1.09 
                 0.755 
                 3047 
               
               
                 C11 
                 rs12292613 
                 7580592 
                 T 
                 0.890 
                 28149 
                 0.0001 
                 1.24 
                 0.910 
                 2362 
                 0.00018 
                 1.20 
                 0.907 
                 3011 
               
               
                 C11 
                 rs10500734 
                 10898494 
                 A 
                 0.771 
                 28271 
                 0.006 
                 1.12 
                 0.789 
                 2385 
                 0.025 
                 1.08 
                 0.785 
                 3035 
               
               
                 C11 
                 rs3935878 
                 12963973 
                 T 
                 0.740 
                 28267 
                 0.000093 
                 1.16 
                 0.767 
                 2392 
                 0.00024 
                 1.13 
                 0.763 
                 3039 
               
               
                 C11 
                 rs10832223 
                 14142269 
                 T 
                 0.841 
                 28293 
                 0.083 
                 1.08 
                 0.851 
                 2395 
                 0.046 
                 1.09 
                 0.851 
                 3047 
               
               
                 C11 
                 rs7946133 
                 17748398 
                 T 
                 0.914 
                 28127 
                 0.02 
                 1.15 
                 0.925 
                 2332 
                 0.12 
                 1.09 
                 0.920 
                 2977 
               
               
                 C11 
                 rs2237921 
                 17894230 
                 C 
                 0.159 
                 28318 
                 0.0049 
                 1.13 
                 0.176 
                 2395 
                 0.014 
                 1.10 
                 0.172 
                 3046 
               
               
                 C11 
                 rs3993323 
                 17910658 
                 A 
                 0.143 
                 28305 
                 0.004 
                 1.14 
                 0.160 
                 2392 
                 0.0089 
                 1.11 
                 0.157 
                 3043 
               
               
                 C11 
                 rs920671 
                 20006628 
                 A 
                 0.187 
                 28318 
                 0.11 
                 1.07 
                 0.197 
                 2395 
                 0.2 
                 1.05 
                 0.195 
                 3047 
               
               
                 C11 
                 rs920675 
                 20006846 
                 A 
                 0.363 
                 28319 
                 0.0039 
                 1.10 
                 0.386 
                 2394 
                 0.0041 
                 1.09 
                 0.383 
                 3046 
               
               
                 C11 
                 rs10836066 
                 33455044 
                 T 
                 0.303 
                 28316 
                 0.00026 
                 1.14 
                 0.330 
                 2395 
                 0.042 
                 1.07 
                 0.317 
                 3046 
               
               
                 C11 
                 rs1532096 
                 42869929 
                 T 
                 0.860 
                 28317 
                 0.0012 
                 1.17 
                 0.878 
                 2395 
                 0.0024 
                 1.14 
                 0.875 
                 3047 
               
               
                 C11 
                 rs7939657 
                 42934015 
                 T 
                 0.557 
                 28307 
                 0.021 
                 1.08 
                 0.575 
                 2395 
                 0.018 
                 1.07 
                 0.574 
                 3047 
               
               
                 C11 
                 rs10838271 
                 44341504 
                 C 
                 0.216 
                 28257 
                 0.019 
                 1.10 
                 0.232 
                 2392 
                 0.034 
                 1.08 
                 0.229 
                 3042 
               
               
                 C11 
                 rs717117 
                 56651181 
                 G 
                 0.077 
                 28317 
                 0.037 
                 1.13 
                 0.086 
                 2395 
                 0.048 
                 1.11 
                 0.085 
                 3047 
               
               
                 C11 
                 rs1005858 
                 68613492 
                 G 
                 0.471 
                 28318 
                 0.0019 
                 1.11 
                 0.496 
                 2395 
                 0.015 
                 1.07 
                 0.489 
                 3047 
               
               
                 C11 
                 rs7111999 
                 68617234 
                 G 
                 0.471 
                 27937 
                 0.0018 
                 1.11 
                 0.496 
                 2354 
                 0.013 
                 1.08 
                 0.489 
                 2996 
               
               
                 C11 
                 rs2924536 
                 68626681 
                 A 
                 0.448 
                 28308 
                 0.0024 
                 1.10 
                 0.473 
                 2394 
                 0.012 
                 1.08 
                 0.467 
                 3046 
               
               
                 C11 
                 rs4623925 
                 82740177 
                 A 
                 0.270 
                 28306 
                 0.0021 
                 1.12 
                 0.293 
                 2395 
                 0.013 
                 1.09 
                 0.287 
                 3047 
               
               
                 C11 
                 rs2163612 
                 82856844 
                 G 
                 0.479 
                 28294 
                 0.000001 
                 1.17 
                 0.519 
                 2393 
                 0.0000036 
                 1.15 
                 0.513 
                 3045 
               
               
                 C11 
                 rs7952084 
                 83059967 
                 A 
                 0.358 
                 28300 
                 0.0018 
                 1.11 
                 0.382 
                 2395 
                 0.0061 
                 1.09 
                 0.377 
                 3046 
               
               
                 C11 
                 rs1436622 
                 90698546 
                 A 
                 0.686 
                 28303 
                 0.00056 
                 1.13 
                 0.712 
                 2395 
                 0.00023 
                 1.13 
                 0.711 
                 3047 
               
               
                 C11 
                 rs2568712 
                 91046953 
                 T 
                 0.389 
                 28264 
                 0.00072 
                 1.12 
                 0.416 
                 2392 
                 0.014 
                 1.08 
                 0.407 
                 3043 
               
               
                 C11 
                 rs808003 
                 91127230 
                 T 
                 0.554 
                 28317 
                 0.0003 
                 1.13 
                 0.583 
                 2395 
                 0.0053 
                 1.09 
                 0.574 
                 3047 
               
               
                 C11 
                 rs9971402 
                 92396199 
                 C 
                 0.872 
                 28196 
                 0.0066 
                 1.15 
                 0.887 
                 2388 
                 0.034 
                 1.10 
                 0.882 
                 3038 
               
               
                 C11 
                 rs2658801 
                 92856399 
                 A 
                 0.273 
                 28317 
                 0.023 
                 1.09 
                 0.290 
                 2395 
                 0.004 
                 1.10 
                 0.292 
                 3047 
               
               
                 C11 
                 rs1039953 
                 97062996 
                 C 
                 0.680 
                 28302 
                 0.011 
                 1.09 
                 0.700 
                 2395 
                 0.0066 
                 1.09 
                 0.699 
                 3047 
               
               
                 C11 
                 rs7120353 
                 98546758 
                 T 
                 0.903 
                 28289 
                 0.036 
                 1.13 
                 0.913 
                 2395 
                 0.017 
                 1.13 
                 0.914 
                 3047 
               
               
                 C11 
                 rs1461684 
                 98601689 
                 T 
                 0.854 
                 28312 
                 0.072 
                 1.09 
                 0.864 
                 2395 
                 0.045 
                 1.09 
                 0.864 
                 3047 
               
               
                 C11 
                 rs11225090 
                 101337818 
                 T 
                 0.966 
                 28172 
                 0.00053 
                 1.42 
                 0.976 
                 2340 
                 0.0024 
                 1.31 
                 0.974 
                 2989 
               
               
                 C11 
                 rs1276252 
                 102039767 
                 G 
                 0.255 
                 28318 
                 0.031 
                 1.08 
                 0.270 
                 2395 
                 0.09 
                 1.06 
                 0.266 
                 3047 
               
               
                 C11 
                 rs719527 
                 102945919 
                 C 
                 0.236 
                 28278 
                 0.019 
                 1.09 
                 0.252 
                 2395 
                 0.045 
                 1.07 
                 0.248 
                 3047 
               
               
                 C11 
                 rs10502020 
                 103220691 
                 G 
                 0.449 
                 28319 
                 0.0071 
                 1.09 
                 0.471 
                 2395 
                 0.0056 
                 1.09 
                 0.469 
                 3046 
               
               
                 C11 
                 rs1509729 
                 108432693 
                 G 
                 0.691 
                 28318 
                 0.0051 
                 1.11 
                 0.712 
                 2395 
                 0.0074 
                 1.09 
                 0.709 
                 3047 
               
               
                 C11 
                 rs11604632 
                 110013250 
                 A 
                 0.173 
                 28295 
                 0.001 
                 1.15 
                 0.194 
                 2395 
                 0.000026 
                 1.17 
                 0.197 
                 3045 
               
               
                 C11 
                 rs531743 
                 121625352 
                 A 
                 0.955 
                 28306 
                 0.00062 
                 1.34 
                 0.966 
                 2393 
                 0.0032 
                 1.25 
                 0.964 
                 3045 
               
               
                 C11 
                 rs4936757 
                 122257924 
                 C 
                 0.567 
                 28307 
                 0.011 
                 1.09 
                 0.588 
                 2395 
                 0.0084 
                 1.08 
                 0.587 
                 3047 
               
               
                 C11 
                 rs7933433 
                 127699660 
                 G 
                 0.648 
                 28312 
                 0.0055 
                 1.10 
                 0.670 
                 2394 
                 0.006 
                 1.09 
                 0.668 
                 3046 
               
               
                 C11 
                 rs1395504 
                 132234377 
                 A 
                 0.497 
                 28319 
                 0.033 
                 1.07 
                 0.514 
                 2395 
                 0.031 
                 1.07 
                 0.513 
                 3047 
               
               
                 C11 
                 rs1289455 
                 134148357 
                 T 
                 0.150 
                 28259 
                 0.0013 
                 1.15 
                 0.169 
                 2391 
                 0.00055 
                 1.15 
                 0.169 
                 3042 
               
               
                 C11 
                 rs1289450 
                 134151851 
                 A 
                 0.198 
                 28099 
                 0.00044 
                 1.15 
                 0.222 
                 2390 
                 0.00015 
                 1.15 
                 0.221 
                 3039 
               
               
                 C12 
                 rs797773 
                 6177827 
                 T 
                 0.401 
                 28283 
                 0.00077 
                 1.12 
                 0.428 
                 2393 
                 0.0082 
                 1.08 
                 0.420 
                 3044 
               
               
                 C12 
                 rs2160424 
                 9180220 
                 G 
                 0.556 
                 28256 
                 0.00048 
                 1.12 
                 0.585 
                 2384 
                 0.0016 
                 1.10 
                 0.579 
                 3035 
               
               
                 C12 
                 rs3213831 
                 9208040 
                 T 
                 0.547 
                 28320 
                 0.019 
                 1.08 
                 0.566 
                 2395 
                 0.012 
                 1.08 
                 0.566 
                 3047 
               
               
                 C12 
                 rs3782677 
                 9208670 
                 C 
                 0.548 
                 28320 
                 0.017 
                 1.08 
                 0.567 
                 2395 
                 0.011 
                 1.08 
                 0.566 
                 3047 
               
               
                 C12 
                 rs9805106 
                 19263624 
                 G 
                 0.822 
                 28153 
                 0.021 
                 1.11 
                 0.836 
                 2380 
                 0.0052 
                 1.12 
                 0.838 
                 3028 
               
               
                 C12 
                 rs10743315 
                 19360345 
                 G 
                 0.882 
                 28166 
                 0.023 
                 1.13 
                 0.894 
                 2384 
                 0.017 
                 1.12 
                 0.893 
                 3035 
               
               
                 C12 
                 rs2417821 
                 20081535 
                 T 
                 0.754 
                 28317 
                 0.014 
                 1.10 
                 0.771 
                 2395 
                 0.0042 
                 1.11 
                 0.772 
                 3047 
               
               
                 C12 
                 rs11045018 
                 20118148 
                 G 
                 0.752 
                 28298 
                 0.01 
                 1.10 
                 0.770 
                 2394 
                 0.0071 
                 1.10 
                 0.769 
                 3046 
               
               
                 C12 
                 rs7299937 
                 20196656 
                 T 
                 0.060 
                 28243 
                 0.0014 
                 1.23 
                 0.073 
                 2394 
                 0.0079 
                 1.17 
                 0.069 
                 3045 
               
               
                 C12 
                 rs3764006 
                 20945636 
                 C 
                 0.104 
                 28304 
                 0.022 
                 1.13 
                 0.116 
                 2395 
                 0.022 
                 1.11 
                 0.115 
                 3047 
               
               
                 C12 
                 rs1910186 
                 21065184 
                 C 
                 0.111 
                 28301 
                 0.01 
                 1.14 
                 0.124 
                 2395 
                 0.02 
                 1.11 
                 0.122 
                 3047 
               
               
                 C12 
                 rs11045689 
                 21092930 
                 G 
                 0.301 
                 28210 
                 0.017 
                 1.09 
                 0.319 
                 2386 
                 0.015 
                 1.08 
                 0.317 
                 3037 
               
               
                 C12 
                 rs2955503 
                 22090132 
                 A 
                 0.655 
                 28289 
                 0.00054 
                 1.13 
                 0.681 
                 2394 
                 0.000033 
                 1.14 
                 0.684 
                 3045 
               
               
                 C12 
                 rs2171392 
                 22797592 
                 A 
                 0.196 
                 28289 
                 0.0068 
                 1.12 
                 0.213 
                 2394 
                 0.011 
                 1.10 
                 0.211 
                 3045 
               
               
                 C12 
                 rs16925384 
                 22807863 
                 A 
                 0.195 
                 28302 
                 0.0069 
                 1.12 
                 0.213 
                 2394 
                 0.0098 
                 1.10 
                 0.210 
                 3046 
               
               
                 C12 
                 rs12425518 
                 47206273 
                 A 
                 0.046 
                 28295 
                 0.031 
                 1.17 
                 0.054 
                 2392 
                 0.15 
                 1.10 
                 0.051 
                 3042 
               
               
                 C12 
                 rs12581026 
                 47223943 
                 C 
                 0.048 
                 28310 
                 0.0073 
                 1.21 
                 0.058 
                 2394 
                 0.059 
                 1.13 
                 0.054 
                 3046 
               
               
                 C12 
                 rs784563 
                 52152886 
                 G 
                 0.445 
                 28308 
                 0.049 
                 1.07 
                 0.461 
                 2395 
                 0.12 
                 1.05 
                 0.457 
                 3047 
               
               
                 C12 
                 rs6580960 
                 52445647 
                 A 
                 0.544 
                 28320 
                 0.068 
                 1.06 
                 0.558 
                 2395 
                 0.06 
                 1.06 
                 0.557 
                 3047 
               
               
                 C12 
                 rs10878126 
                 62930978 
                 G 
                 0.495 
                 28299 
                 0.016 
                 1.08 
                 0.515 
                 2395 
                 0.017 
                 1.07 
                 0.513 
                 3046 
               
               
                 C12 
                 rs1465026 
                 65789635 
                 G 
                 0.837 
                 28309 
                 0.011 
                 1.12 
                 0.852 
                 2395 
                 0.024 
                 1.10 
                 0.849 
                 3047 
               
               
                 C12 
                 rs1526839 
                 65801361 
                 G 
                 0.837 
                 28240 
                 0.019 
                 1.11 
                 0.851 
                 2392 
                 0.037 
                 1.09 
                 0.848 
                 3042 
               
               
                 C12 
                 rs11835794 
                 65812323 
                 T 
                 0.858 
                 28321 
                 0.056 
                 1.10 
                 0.868 
                 2395 
                 0.095 
                 1.07 
                 0.866 
                 3047 
               
               
                 C12 
                 rs1470383 
                 67493429 
                 C 
                 0.144 
                 28320 
                 0.0068 
                 1.13 
                 0.160 
                 2395 
                 0.0065 
                 1.12 
                 0.159 
                 3047 
               
               
                 C12 
                 rs2584019 
                 69318052 
                 T 
                 0.889 
                 11415 
                 0.00091 
                 1.24 
                 0.909 
                 1775 
                 0.0015 
                 1.21 
                 0.907 
                 2094 
               
               
                 C12 
                 rs7978668 
                 69325443 
                 T 
                 0.917 
                 28319 
                 0.0043 
                 1.19 
                 0.929 
                 2395 
                 0.0082 
                 1.16 
                 0.927 
                 3047 
               
               
                 C12 
                 rs767760 
                 69326403 
                 A 
                 0.914 
                 28320 
                 0.0041 
                 1.19 
                 0.927 
                 2395 
                 0.0068 
                 1.16 
                 0.925 
                 3047 
               
               
                 C12 
                 rs7309888 
                 69340682 
                 C 
                 0.794 
                 28317 
                 0.0034 
                 1.13 
                 0.813 
                 2395 
                 0.00095 
                 1.13 
                 0.814 
                 3047 
               
               
                 C12 
                 rs7976576 
                 69347673 
                 T 
                 0.795 
                 28318 
                 0.0049 
                 1.12 
                 0.813 
                 2395 
                 0.0015 
                 1.13 
                 0.813 
                 3046 
               
               
                 C12 
                 rs949664 
                 69368222 
                 A 
                 0.860 
                 28228 
                 0.0019 
                 1.16 
                 0.878 
                 2393 
                 0.0015 
                 1.15 
                 0.876 
                 3043 
               
               
                 C12 
                 rs7135414 
                 75996159 
                 A 
                 0.917 
                 28317 
                 0.0074 
                 1.18 
                 0.928 
                 2395 
                 0.0029 
                 1.18 
                 0.928 
                 3047 
               
               
                 C12 
                 rs1401875 
                 87986337 
                 T 
                 0.058 
                 28291 
                 0.095 
                 1.12 
                 0.064 
                 2392 
                 0.056 
                 1.12 
                 0.065 
                 3041 
               
               
                 C12 
                 rs1568383 
                 88017285 
                 T 
                 0.098 
                 28316 
                 0.008 
                 1.15 
                 0.111 
                 2395 
                 0.0049 
                 1.14 
                 0.110 
                 3045 
               
               
                 C12 
                 rs11108788 
                 95989532 
                 G 
                 0.036 
                 27597 
                 0.0085 
                 1.24 
                 0.044 
                 2388 
                 0.035 
                 1.17 
                 0.041 
                 3040 
               
               
                 C12 
                 rs989264 
                 96044433 
                 A 
                 0.044 
                 28316 
                 0.14 
                 1.12 
                 0.049 
                 2395 
                 0.18 
                 1.10 
                 0.049 
                 3047 
               
               
                 C12 
                 rs7135604 
                 96910191 
                 A 
                 0.657 
                 28303 
                 0.0022 
                 1.11 
                 0.680 
                 2394 
                 0.0076 
                 1.09 
                 0.676 
                 3045 
               
               
                 C12 
                 rs864302 
                 100490144 
                 T 
                 0.483 
                 28309 
                 0.033 
                 1.07 
                 0.501 
                 2395 
                 0.035 
                 1.06 
                 0.499 
                 3047 
               
               
                 C12 
                 rs12311520 
                 101693527 
                 C 
                 0.870 
                 28247 
                 0.09 
                 1.09 
                 0.879 
                 2395 
                 0.23 
                 1.06 
                 0.876 
                 3046 
               
               
                 C12 
                 rs2247919 
                 101699389 
                 T 
                 0.742 
                 28307 
                 0.071 
                 1.07 
                 0.755 
                 2395 
                 0.28 
                 1.04 
                 0.749 
                 3046 
               
               
                 C12 
                 rs1015249 
                 111609694 
                 C 
                 0.692 
                 28316 
                 0.0002 
                 1.14 
                 0.720 
                 2395 
                 0.00038 
                 1.12 
                 0.716 
                 3046 
               
               
                 C12 
                 rs1293758 
                 111917970 
                 A 
                 0.408 
                 28316 
                 0.0027 
                 1.10 
                 0.432 
                 2394 
                 0.0041 
                 1.09 
                 0.429 
                 3046 
               
               
                 C12 
                 rs249047 
                 112562237 
                 A 
                 0.614 
                 28289 
                 0.000091 
                 1.14 
                 0.645 
                 2392 
                 0.0015 
                 1.10 
                 0.637 
                 3044 
               
               
                 C12 
                 rs1920947 
                 114285453 
                 C 
                 0.810 
                 28301 
                 0.012 
                 1.11 
                 0.826 
                 2394 
                 0.014 
                 1.10 
                 0.824 
                 3046 
               
               
                 C12 
                 rs816204 
                 116492124 
                 A 
                 0.855 
                 28175 
                 0.0023 
                 1.16 
                 0.872 
                 2384 
                 0.0033 
                 1.14 
                 0.870 
                 3034 
               
               
                 C12 
                 rs4767629 
                 116739460 
                 T 
                 0.140 
                 28316 
                 0.025 
                 1.11 
                 0.153 
                 2395 
                 0.06 
                 1.08 
                 0.150 
                 3047 
               
               
                 C12 
                 rs2592289 
                 116759379 
                 A 
                 0.156 
                 28311 
                 0.0039 
                 1.13 
                 0.173 
                 2395 
                 0.0013 
                 1.14 
                 0.173 
                 3047 
               
               
                 C12 
                 rs719450 
                 119438416 
                 C 
                 0.918 
                 28320 
                 0.024 
                 1.15 
                 0.928 
                 2394 
                 0.019 
                 1.14 
                 0.928 
                 3046 
               
               
                 C12 
                 rs3742049 
                 119438873 
                 C 
                 0.919 
                 28300 
                 0.029 
                 1.14 
                 0.928 
                 2394 
                 0.023 
                 1.13 
                 0.928 
                 3046 
               
               
                 C12 
                 rs1169081 
                 120890295 
                 C 
                 0.693 
                 28306 
                 0.0032 
                 1.11 
                 0.715 
                 2394 
                 0.06 
                 1.06 
                 0.706 
                 3045 
               
               
                 C12 
                 rs7979863 
                 121629420 
                 A 
                 0.380 
                 28309 
                 0.022 
                 1.08 
                 0.399 
                 2395 
                 0.0025 
                 1.10 
                 0.402 
                 3047 
               
               
                 C12 
                 rs10847227 
                 121632638 
                 T 
                 0.279 
                 28258 
                 0.012 
                 1.09 
                 0.297 
                 2395 
                 0.00028 
                 1.12 
                 0.303 
                 3047 
               
               
                 C12 
                 rs4765477 
                 123287223 
                 T 
                 0.045 
                 28300 
                 0.016 
                 1.20 
                 0.053 
                 2395 
                 0.023 
                 1.17 
                 0.052 
                 3047 
               
               
                 C12 
                 rs3759107 
                 123548064 
                 T 
                 0.127 
                 28320 
                 0.023 
                 1.11 
                 0.139 
                 2395 
                 0.014 
                 1.11 
                 0.139 
                 3047 
               
               
                 C12 
                 rs12304836 
                 124654446 
                 C 
                 0.143 
                 28205 
                 0.00054 
                 1.17 
                 0.163 
                 2385 
                 0.00095 
                 1.14 
                 0.160 
                 3034 
               
               
                 C12 
                 rs7310042 
                 124675580 
                 G 
                 0.192 
                 28317 
                 0.018 
                 1.10 
                 0.207 
                 2395 
                 0.0043 
                 1.11 
                 0.209 
                 3047 
               
               
                 C12 
                 rs470477 
                 128010541 
                 T 
                 0.311 
                 28306 
                 0.0061 
                 1.10 
                 0.332 
                 2395 
                 0.013 
                 1.08 
                 0.328 
                 3046 
               
               
                 C13 
                 rs4770252 
                 21699475 
                 A 
                 0.806 
                 28293 
                 0.0088 
                 1.12 
                 0.822 
                 2394 
                 0.016 
                 1.10 
                 0.819 
                 3044 
               
               
                 C13 
                 rs9285207 
                 21722774 
                 C 
                 0.200 
                 28256 
                 0.0015 
                 1.13 
                 0.220 
                 2387 
                 0.0061 
                 1.10 
                 0.216 
                 3037 
               
               
                 C13 
                 rs1887263 
                 22381716 
                 A 
                 0.204 
                 28175 
                 0.067 
                 1.08 
                 0.216 
                 2393 
                 0.037 
                 1.08 
                 0.217 
                 3042 
               
               
                 C13 
                 rs4769613 
                 28036609 
                 T 
                 0.465 
                 28313 
                 0.00041 
                 1.12 
                 0.494 
                 2394 
                 0.00013 
                 1.12 
                 0.493 
                 3046 
               
               
                 C13 
                 rs9566343 
                 38000184 
                 T 
                 0.814 
                 28309 
                 0.011 
                 1.11 
                 0.830 
                 2395 
                 0.013 
                 1.10 
                 0.828 
                 3046 
               
               
                 C13 
                 rs9315759 
                 39616680 
                 C 
                 0.132 
                 28308 
                 0.0045 
                 1.14 
                 0.147 
                 2394 
                 0.0045 
                 1.13 
                 0.146 
                 3046 
               
               
                 C13 
                 rs9525923 
                 43681715 
                 A 
                 0.210 
                 28320 
                 0.00015 
                 1.16 
                 0.236 
                 2395 
                 0.0019 
                 1.12 
                 0.229 
                 3047 
               
               
                 C13 
                 rs963569 
                 44140379 
                 A 
                 0.753 
                 28315 
                 0.0074 
                 1.11 
                 0.771 
                 2395 
                 0.037 
                 1.08 
                 0.766 
                 3047 
               
               
                 C13 
                 rs7322927 
                 46552894 
                 A 
                 0.129 
                 28318 
                 0.021 
                 1.12 
                 0.142 
                 2395 
                 0.059 
                 1.09 
                 0.139 
                 3047 
               
               
                 C13 
                 rs9534568 
                 46693565 
                 A 
                 0.769 
                 11414 
                 0.086 
                 1.08 
                 0.783 
                 1775 
                 0.094 
                 1.08 
                 0.782 
                 2094 
               
               
                 C13 
                 rs9526329 
                 46866462 
                 G 
                 0.922 
                 28290 
                 0.00038 
                 1.26 
                 0.937 
                 2395 
                 0.0067 
                 1.17 
                 0.933 
                 3047 
               
               
                 C13 
                 rs2050972 
                 54308642 
                 C 
                 0.881 
                 28309 
                 0.01 
                 1.14 
                 0.894 
                 2395 
                 0.011 
                 1.13 
                 0.893 
                 3047 
               
               
                 C13 
                 rs1993776 
                 54406486 
                 C 
                 0.872 
                 28309 
                 0.011 
                 1.14 
                 0.885 
                 2395 
                 0.011 
                 1.12 
                 0.884 
                 3047 
               
               
                 C13 
                 rs17070671 
                 67943127 
                 T 
                 0.830 
                 28318 
                 0.00076 
                 1.16 
                 0.850 
                 2395 
                 0.017 
                 1.10 
                 0.843 
                 3047 
               
               
                 C13 
                 rs1375719 
                 102208783 
                 C 
                 0.499 
                 28316 
                 0.032 
                 1.07 
                 0.517 
                 2394 
                 0.12 
                 1.05 
                 0.511 
                 3046 
               
               
                 C13 
                 rs2038709 
                 102370990 
                 C 
                 0.084 
                 28237 
                 0.0084 
                 1.16 
                 0.096 
                 2393 
                 0.038 
                 1.11 
                 0.093 
                 3045 
               
               
                 C13 
                 rs1347329 
                 104032541 
                 C 
                 0.592 
                 11392 
                 0.005 
                 1.12 
                 0.619 
                 1775 
                 0.031 
                 1.09 
                 0.612 
                 2093 
               
               
                 C13 
                 rs354438 
                 105737486 
                 T 
                 0.355 
                 28306 
                 0.12 
                 1.05 
                 0.367 
                 2395 
                 0.33 
                 1.03 
                 0.362 
                 3047 
               
               
                 C13 
                 rs1927771 
                 106592839 
                 A 
                 0.416 
                 28317 
                 0.05 
                 1.07 
                 0.432 
                 2395 
                 0.078 
                 1.05 
                 0.429 
                 3046 
               
               
                 C13 
                 rs1163852 
                 110962872 
                 C 
                 0.713 
                 28319 
                 0.0031 
                 1.11 
                 0.735 
                 2395 
                 0.0056 
                 1.10 
                 0.732 
                 3046 
               
               
                 C14 
                 rs10872856 
                 20356515 
                 C 
                 0.914 
                 28314 
                 0.04 
                 1.13 
                 0.923 
                 2395 
                 0.022 
                 1.13 
                 0.923 
                 3047 
               
               
                 C14 
                 rs991387 
                 32384515 
                 G 
                 0.803 
                 28319 
                 0.026 
                 1.10 
                 0.818 
                 2394 
                 0.047 
                 1.08 
                 0.815 
                 3046 
               
               
                 C14 
                 rs1950216 
                 32385175 
                 T 
                 0.803 
                 28318 
                 0.027 
                 1.10 
                 0.818 
                 2395 
                 0.048 
                 1.08 
                 0.815 
                 3047 
               
               
                 C14 
                 rs1742655 
                 45622604 
                 C 
                 0.885 
                 28321 
                 0.0015 
                 1.19 
                 0.901 
                 2395 
                 0.0049 
                 1.14 
                 0.898 
                 3047 
               
               
                 C14 
                 rs8007161 
                 49042790 
                 T 
                 0.886 
                 28278 
                 0.027 
                 1.12 
                 0.898 
                 2393 
                 0.085 
                 1.09 
                 0.894 
                 3044 
               
               
                 C14 
                 rs12436454 
                 49076076 
                 T 
                 0.717 
                 28226 
                 0.0028 
                 1.12 
                 0.738 
                 2393 
                 0.012 
                 1.09 
                 0.733 
                 3044 
               
               
                 C14 
                 rs4898630 
                 49269010 
                 A 
                 0.878 
                 28293 
                 0.0079 
                 1.15 
                 0.892 
                 2394 
                 0.022 
                 1.11 
                 0.889 
                 3046 
               
               
                 C14 
                 rs1458114 
                 52093597 
                 T 
                 0.706 
                 27829 
                 0.0005 
                 1.14 
                 0.732 
                 2338 
                 0.0043 
                 1.10 
                 0.725 
                 2979 
               
               
                 C14 
                 rs4444235 
                 53480669 
                 T 
                 0.536 
                 28305 
                 0.37 
                 1.03 
                 0.543 
                 2394 
                 0.32 
                 1.03 
                 0.543 
                 3046 
               
               
                 C14 
                 rs1957860 
                 53499105 
                 T 
                 0.448 
                 28313 
                 0.27 
                 0.97 
                 0.439 
                 2395 
                 0.55 
                 0.98 
                 0.444 
                 3047 
               
               
                 C14 
                 rs392030 
                 58368609 
                 G 
                 0.636 
                 28319 
                 0.015 
                 1.09 
                 0.654 
                 2395 
                 0.029 
                 1.07 
                 0.651 
                 3047 
               
               
                 C14 
                 rs2069334 
                 58368941 
                 A 
                 0.188 
                 28314 
                 0.043 
                 1.09 
                 0.201 
                 2395 
                 0.099 
                 1.06 
                 0.197 
                 3047 
               
               
                 C14 
                 rs17095237 
                 58383406 
                 G 
                 0.164 
                 28314 
                 0.056 
                 1.09 
                 0.176 
                 2395 
                 0.17 
                 1.06 
                 0.172 
                 3046 
               
               
                 C14 
                 rs10483707 
                 58477558 
                 A 
                 0.141 
                 28319 
                 0.054 
                 1.09 
                 0.152 
                 2395 
                 0.14 
                 1.06 
                 0.148 
                 3047 
               
               
                 C14 
                 rs11158238 
                 58517378 
                 T 
                 0.142 
                 28317 
                 0.06 
                 1.09 
                 0.153 
                 2395 
                 0.11 
                 1.07 
                 0.150 
                 3047 
               
               
                 C14 
                 rs7147624 
                 64935378 
                 G 
                 0.801 
                 28311 
                 0.011 
                 1.11 
                 0.817 
                 2395 
                 0.034 
                 1.08 
                 0.813 
                 3046 
               
               
                 C14 
                 rs2411822 
                 64948148 
                 C 
                 0.486 
                 28314 
                 0.024 
                 1.08 
                 0.505 
                 2395 
                 0.11 
                 1.05 
                 0.498 
                 3047 
               
               
                 C14 
                 rs1953416 
                 64948560 
                 T 
                 0.483 
                 28267 
                 0.016 
                 1.08 
                 0.503 
                 2391 
                 0.073 
                 1.05 
                 0.497 
                 3042 
               
               
                 C14 
                 rs7145500 
                 64953965 
                 A 
                 0.663 
                 28319 
                 0.031 
                 1.08 
                 0.679 
                 2395 
                 0.05 
                 1.06 
                 0.676 
                 3047 
               
               
                 C14 
                 rs12433694 
                 65380138 
                 C 
                 0.483 
                 28319 
                 0.031 
                 1.07 
                 0.500 
                 2395 
                 0.1 
                 1.05 
                 0.494 
                 3047 
               
               
                 C14 
                 rs1147443 
                 65538514 
                 T 
                 0.251 
                 28316 
                 0.000014 
                 1.17 
                 0.282 
                 2395 
                 0.0000074 
                 1.16 
                 0.280 
                 3047 
               
               
                 C14 
                 rs1147437 
                 65544105 
                 G 
                 0.380 
                 28316 
                 0.000065 
                 1.14 
                 0.412 
                 2395 
                 0.000058 
                 1.13 
                 0.409 
                 3046 
               
               
                 C14 
                 rs894921 
                 65546005 
                 G 
                 0.376 
                 28318 
                 0.000056 
                 1.14 
                 0.408 
                 2395 
                 0.000054 
                 1.13 
                 0.405 
                 3047 
               
               
                 C14 
                 rs6573648 
                 65617378 
                 G 
                 0.272 
                 28316 
                 0.000041 
                 1.16 
                 0.302 
                 2395 
                 0.000028 
                 1.15 
                 0.300 
                 3047 
               
               
                 C14 
                 rs17754686 
                 65667738 
                 A 
                 0.307 
                 28239 
                 0.00015 
                 1.14 
                 0.335 
                 2392 
                 0.00007 
                 1.13 
                 0.334 
                 3044 
               
               
                 C14 
                 rs8003722 
                 68388015 
                 A 
                 0.106 
                 28317 
                 0.0085 
                 1.14 
                 0.119 
                 2394 
                 0.024 
                 1.11 
                 0.116 
                 3046 
               
               
                 C14 
                 rs1291302 
                 69449823 
                 C 
                 0.265 
                 28043 
                 0.13 
                 1.06 
                 0.276 
                 2363 
                 0.22 
                 1.04 
                 0.273 
                 3015 
               
               
                 C14 
                 rs10498639 
                 93845279 
                 A 
                 0.428 
                 28316 
                 0.0088 
                 1.09 
                 0.449 
                 2395 
                 0.018 
                 1.07 
                 0.445 
                 3047 
               
               
                 C14 
                 rs2281519 
                 93846385 
                 T 
                 0.260 
                 28281 
                 0.0023 
                 1.12 
                 0.282 
                 2395 
                 0.014 
                 1.09 
                 0.276 
                 3045 
               
               
                 C14 
                 rs2895811 
                 99203695 
                 C 
                 0.449 
                 28199 
                 0.0018 
                 1.11 
                 0.474 
                 2385 
                 0.0015 
                 1.10 
                 0.472 
                 3033 
               
               
                 C14 
                 rs7158073 
                 99211442 
                 T 
                 0.430 
                 28102 
                 0.0005 
                 1.12 
                 0.458 
                 2379 
                 0.0016 
                 1.10 
                 0.453 
                 3027 
               
               
                 C14 
                 rs12435918 
                 99240648 
                 G 
                 0.333 
                 28318 
                 0.0006 
                 1.12 
                 0.359 
                 2395 
                 0.0016 
                 1.10 
                 0.355 
                 3047 
               
               
                 C14 
                 rs2273840 
                 99257897 
                 A 
                 0.931 
                 28124 
                 0.0031 
                 1.22 
                 0.943 
                 2369 
                 0.0035 
                 1.20 
                 0.941 
                 3019 
               
               
                 C14 
                 rs17776453 
                 100774793 
                 G 
                 0.955 
                 28313 
                 0.095 
                 1.15 
                 0.961 
                 2394 
                 0.033 
                 1.17 
                 0.962 
                 3045 
               
               
                 C14 
                 rs4708 
                 102469201 
                 A 
                 0.549 
                 28293 
                 0.007 
                 1.09 
                 0.571 
                 2393 
                 0.019 
                 1.07 
                 0.566 
                 3043 
               
               
                 C14 
                 rs10129841 
                 102473912 
                 A 
                 0.578 
                 28316 
                 0.0014 
                 1.11 
                 0.604 
                 2395 
                 0.012 
                 1.08 
                 0.596 
                 3047 
               
               
                 C14 
                 rs8016595 
                 103791279 
                 C 
                 0.756 
                 28304 
                 0.016 
                 1.10 
                 0.773 
                 2395 
                 0.04 
                 1.07 
                 0.769 
                 3047 
               
               
                 C15 
                 rs4572353 
                 24287601 
                 T 
                 0.498 
                 28314 
                 0.0003 
                 1.13 
                 0.528 
                 2393 
                 0.00013 
                 1.12 
                 0.526 
                 3043 
               
               
                 C15 
                 rs2110209 
                 24946433 
                 A 
                 0.048 
                 28318 
                 0.00051 
                 1.28 
                 0.061 
                 2395 
                 0.0061 
                 1.20 
                 0.057 
                 3047 
               
               
                 C15 
                 rs4779984 
                 30302218 
                 G 
                 0.100 
                 28236 
                 0.0015 
                 1.18 
                 0.116 
                 2392 
                 0.003 
                 1.15 
                 0.114 
                 3043 
               
               
                 C15 
                 rs7183966 
                 34836718 
                 G 
                 0.129 
                 28307 
                 0.00037 
                 1.18 
                 0.149 
                 2393 
                 0.0032 
                 1.13 
                 0.144 
                 3044 
               
               
                 C15 
                 rs1901725 
                 34837201 
                 T 
                 0.129 
                 28318 
                 0.00038 
                 1.18 
                 0.149 
                 2395 
                 0.0034 
                 1.13 
                 0.144 
                 3047 
               
               
                 C15 
                 rs1194620 
                 34902036 
                 T 
                 0.233 
                 28268 
                 0.0084 
                 1.11 
                 0.251 
                 2394 
                 0.042 
                 1.07 
                 0.246 
                 3044 
               
               
                 C15 
                 rs1841441 
                 37167818 
                 A 
                 0.471 
                 28308 
                 0.021 
                 1.08 
                 0.489 
                 2393 
                 0.0055 
                 1.09 
                 0.491 
                 3045 
               
               
                 C15 
                 rs7172161 
                 43778072 
                 G 
                 0.517 
                 28267 
                 0.067 
                 1.06 
                 0.532 
                 2393 
                 0.045 
                 1.06 
                 0.532 
                 3045 
               
               
                 C15 
                 rs11630033 
                 43850557 
                 C 
                 0.902 
                 28204 
                 0.065 
                 1.11 
                 0.911 
                 2389 
                 0.1 
                 1.09 
                 0.909 
                 3040 
               
               
                 C15 
                 rs1156234 
                 51156742 
                 G 
                 0.795 
                 28314 
                 0.0028 
                 1.13 
                 0.815 
                 2395 
                 0.0077 
                 1.10 
                 0.811 
                 3047 
               
               
                 C15 
                 rs2553223 
                 52657225 
                 G 
                 0.344 
                 28301 
                 0.000086 
                 1.14 
                 0.375 
                 2395 
                 0.00015 
                 1.12 
                 0.371 
                 3047 
               
               
                 C15 
                 rs2414325 
                 52675829 
                 T 
                 0.489 
                 28318 
                 0.00012 
                 1.13 
                 0.520 
                 2395 
                 0.00022 
                 1.12 
                 0.516 
                 3047 
               
               
                 C15 
                 rs8041044 
                 53452605 
                 C 
                 0.915 
                 28200 
                 0.015 
                 1.16 
                 0.925 
                 2389 
                 0.044 
                 1.12 
                 0.923 
                 3039 
               
               
                 C15 
                 rs4775234 
                 58117938 
                 C 
                 0.259 
                 27735 
                 0.0047 
                 1.11 
                 0.280 
                 2354 
                 0.031 
                 1.08 
                 0.273 
                 2995 
               
               
                 C15 
                 rs11072793 
                 76793497 
                 G 
                 0.231 
                 28268 
                 0.00025 
                 1.15 
                 0.257 
                 2388 
                 0.0013 
                 1.12 
                 0.251 
                 3040 
               
               
                 C15 
                 rs4255747 
                 77512872 
                 G 
                 0.677 
                 28311 
                 0.07 
                 1.07 
                 0.691 
                 2395 
                 0.24 
                 1.04 
                 0.685 
                 3047 
               
               
                 C15 
                 rs4887480 
                 84366589 
                 G 
                 0.771 
                 28306 
                 0.0014 
                 1.13 
                 0.793 
                 2395 
                 0.0051 
                 1.11 
                 0.788 
                 3045 
               
               
                 C15 
                 rs12595195 
                 88001739 
                 C 
                 0.280 
                 28292 
                 0.0093 
                 1.10 
                 0.299 
                 2395 
                 0.056 
                 1.06 
                 0.292 
                 3046 
               
               
                 C15 
                 rs3743369 
                 90508573 
                 T 
                 0.616 
                 28313 
                 0.032 
                 1.07 
                 0.633 
                 2394 
                 0.029 
                 1.07 
                 0.632 
                 3046 
               
               
                 C15 
                 rs6496899 
                 90511768 
                 C 
                 0.766 
                 28152 
                 0.02 
                 1.10 
                 0.781 
                 2375 
                 0.014 
                 1.09 
                 0.781 
                 3024 
               
               
                 C15 
                 rs10152962 
                 92112175 
                 G 
                 0.153 
                 28319 
                 0.014 
                 1.11 
                 0.168 
                 2393 
                 0.0078 
                 1.11 
                 0.167 
                 3045 
               
               
                 C15 
                 rs176656 
                 93537286 
                 A 
                 0.093 
                 28317 
                 0.054 
                 1.11 
                 0.103 
                 2395 
                 0.055 
                 1.10 
                 0.102 
                 3047 
               
               
                 C15 
                 rs7177625 
                 95764563 
                 G 
                 0.687 
                 28300 
                 0.029 
                 1.08 
                 0.703 
                 2395 
                 0.16 
                 1.05 
                 0.696 
                 3046 
               
               
                 C15 
                 rs2684790 
                 97309063 
                 T 
                 0.146 
                 28314 
                 0.0036 
                 1.14 
                 0.163 
                 2395 
                 0.011 
                 1.11 
                 0.160 
                 3047 
               
               
                 C16 
                 rs8057913 
                 2009168 
                 C 
                 0.266 
                 28244 
                 0.0066 
                 1.10 
                 0.286 
                 2391 
                 0.0057 
                 1.10 
                 0.285 
                 3042 
               
               
                 C16 
                 rs2286472 
                 2010569 
                 C 
                 0.271 
                 28249 
                 0.011 
                 1.10 
                 0.290 
                 2385 
                 0.007 
                 1.09 
                 0.289 
                 3036 
               
               
                 C16 
                 rs8045288 
                 2013121 
                 T 
                 0.269 
                 28279 
                 0.01 
                 1.10 
                 0.287 
                 2394 
                 0.0082 
                 1.09 
                 0.286 
                 3045 
               
               
                 C16 
                 rs3785284 
                 2014037 
                 C 
                 0.267 
                 28138 
                 0.012 
                 1.10 
                 0.285 
                 2384 
                 0.009 
                 1.09 
                 0.284 
                 3032 
               
               
                 C16 
                 rs8053779 
                 18979415 
                 G 
                 0.738 
                 28314 
                 0.12 
                 1.06 
                 0.749 
                 2395 
                 0.13 
                 1.05 
                 0.748 
                 3047 
               
               
                 C16 
                 rs7500550 
                 18985697 
                 G 
                 0.782 
                 28319 
                 0.065 
                 1.08 
                 0.794 
                 2394 
                 0.045 
                 1.08 
                 0.794 
                 3046 
               
               
                 C16 
                 rs1634675 
                 19801122 
                 G 
                 0.789 
                 28308 
                 0.023 
                 1.10 
                 0.804 
                 2395 
                 0.054 
                 1.07 
                 0.800 
                 3047 
               
               
                 C16 
                 rs8050136 
                 52373776 
                 A 
                 0.404 
                 28316 
                 0.0046 
                 1.10 
                 0.426 
                 2394 
                 0.00029 
                 1.11 
                 0.430 
                 3046 
               
               
                 C16 
                 rs3751812 
                 52375961 
                 T 
                 0.403 
                 28246 
                 0.0041 
                 1.10 
                 0.426 
                 2392 
                 0.00024 
                 1.12 
                 0.430 
                 3044 
               
               
                 C16 
                 rs1033043 
                 52774858 
                 T 
                 0.577 
                 28311 
                 0.027 
                 1.08 
                 0.594 
                 2394 
                 0.052 
                 1.06 
                 0.591 
                 3046 
               
               
                 C16 
                 rs2665282 
                 52779886 
                 A 
                 0.577 
                 28267 
                 0.029 
                 1.07 
                 0.594 
                 2391 
                 0.059 
                 1.06 
                 0.591 
                 3041 
               
               
                 C16 
                 rs12924635 
                 60072235 
                 G 
                 0.397 
                 27765 
                 0.0043 
                 1.10 
                 0.420 
                 2306 
                 0.023 
                 1.07 
                 0.414 
                 2944 
               
               
                 C16 
                 rs2962080 
                 61410292 
                 G 
                 0.609 
                 28310 
                 0.0056 
                 1.10 
                 0.631 
                 2394 
                 0.06 
                 1.06 
                 0.623 
                 3046 
               
               
                 C16 
                 rs7192142 
                 62724486 
                 T 
                 0.810 
                 28254 
                 0.00063 
                 1.16 
                 0.832 
                 2385 
                 0.0059 
                 1.11 
                 0.826 
                 3036 
               
               
                 C16 
                 rs12927636 
                 72310379 
                 G 
                 0.108 
                 28296 
                 0.0028 
                 1.16 
                 0.123 
                 2393 
                 0.0065 
                 1.13 
                 0.121 
                 3045 
               
               
                 C16 
                 rs1038864 
                 72320058 
                 C 
                 0.185 
                 28319 
                 0.012 
                 1.11 
                 0.201 
                 2395 
                 0.019 
                 1.09 
                 0.198 
                 3047 
               
               
                 C16 
                 rs4243110 
                 73810027 
                 T 
                 0.462 
                 28299 
                 0.01 
                 1.09 
                 0.482 
                 2394 
                 0.0043 
                 1.09 
                 0.482 
                 3046 
               
               
                 C16 
                 rs1862737 
                 73839465 
                 C 
                 0.484 
                 28309 
                 0.0017 
                 1.11 
                 0.509 
                 2395 
                 0.0013 
                 1.10 
                 0.508 
                 3046 
               
               
                 C16 
                 rs7188879 
                 78364890 
                 T 
                 0.966 
                 28303 
                 0.048 
                 1.21 
                 0.972 
                 2394 
                 0.11 
                 1.14 
                 0.970 
                 3046 
               
               
                 C16 
                 rs1870843 
                 81316815 
                 T 
                 0.602 
                 28313 
                 0.0081 
                 1.09 
                 0.623 
                 2395 
                 0.0098 
                 1.08 
                 0.621 
                 3047 
               
               
                 C16 
                 rs10514560 
                 81328576 
                 C 
                 0.734 
                 28315 
                 0.011 
                 1.10 
                 0.752 
                 2395 
                 0.022 
                 1.08 
                 0.749 
                 3047 
               
               
                 C16 
                 rs4075964 
                 86985334 
                 A 
                 0.283 
                 28229 
                 0.0063 
                 1.10 
                 0.304 
                 2392 
                 0.016 
                 1.08 
                 0.299 
                 3042 
               
               
                 C16 
                 rs904800 
                 87044441 
                 G 
                 0.383 
                 28296 
                 0.0057 
                 1.10 
                 0.405 
                 2395 
                 0.0062 
                 1.09 
                 0.403 
                 3045 
               
               
                 C17 
                 rs4130140 
                 257873 
                 A 
                 0.174 
                 28319 
                 0.00063 
                 1.15 
                 0.195 
                 2395 
                 0.0027 
                 1.12 
                 0.191 
                 3047 
               
               
                 C17 
                 rs4791759 
                 7618652 
                 A 
                 0.041 
                 28305 
                 0.065 
                 1.16 
                 0.047 
                 2394 
                 0.32 
                 1.07 
                 0.044 
                 3044 
               
               
                 C17 
                 rs3891720 
                 9331114 
                 C 
                 0.872 
                 28298 
                 0.0034 
                 1.16 
                 0.888 
                 2392 
                 0.026 
                 1.11 
                 0.883 
                 3044 
               
               
                 C17 
                 rs9903582 
                 10175559 
                 C 
                 0.749 
                 28317 
                 0.01 
                 1.10 
                 0.767 
                 2395 
                 0.022 
                 1.08 
                 0.764 
                 3047 
               
               
                 C17 
                 rs12449610 
                 13998813 
                 T 
                 0.669 
                 28319 
                 0.0025 
                 1.11 
                 0.692 
                 2395 
                 0.0087 
                 1.09 
                 0.687 
                 3047 
               
               
                 C17 
                 rs2323095 
                 14000644 
                 A 
                 0.664 
                 28312 
                 0.0027 
                 1.11 
                 0.687 
                 2395 
                 0.013 
                 1.08 
                 0.681 
                 3047 
               
               
                 C17 
                 rs2856177 
                 14041754 
                 A 
                 0.622 
                 28308 
                 0.0085 
                 1.09 
                 0.642 
                 2395 
                 0.016 
                 1.08 
                 0.639 
                 3047 
               
               
                 C17 
                 rs4401079 
                 16755421 
                 T 
                 0.211 
                 27570 
                 0.028 
                 1.09 
                 0.226 
                 2340 
                 0.015 
                 1.09 
                 0.226 
                 2975 
               
               
                 C17 
                 rs4925108 
                 17590148 
                 C 
                 0.394 
                 28297 
                 0.0015 
                 1.11 
                 0.420 
                 2394 
                 0.014 
                 1.08 
                 0.412 
                 3046 
               
               
                 C17 
                 rs752579 
                 17601072 
                 G 
                 0.390 
                 28286 
                 0.0051 
                 1.10 
                 0.412 
                 2394 
                 0.043 
                 1.06 
                 0.404 
                 3046 
               
               
                 C17 
                 rs4925109 
                 17602527 
                 A 
                 0.318 
                 28316 
                 0.00032 
                 1.13 
                 0.345 
                 2395 
                 0.0045 
                 1.09 
                 0.337 
                 3047 
               
               
                 C17 
                 rs11649804 
                 17637480 
                 A 
                 0.292 
                 28148 
                 0.00029 
                 1.14 
                 0.319 
                 2341 
                 0.0041 
                 1.10 
                 0.312 
                 2987 
               
               
                 C17 
                 rs4925114 
                 17651995 
                 A 
                 0.357 
                 28266 
                 0.000045 
                 1.15 
                 0.389 
                 2391 
                 0.0017 
                 1.10 
                 0.379 
                 3042 
               
               
                 C17 
                 rs11868035 
                 17655826 
                 A 
                 0.294 
                 28278 
                 0.000068 
                 1.15 
                 0.324 
                 2393 
                 0.0016 
                 1.11 
                 0.315 
                 3043 
               
               
                 C17 
                 rs9902941 
                 17674485 
                 C 
                 0.347 
                 28319 
                 0.0000029 
                 1.17 
                 0.384 
                 2395 
                 0.00095 
                 1.11 
                 0.371 
                 3047 
               
               
                 C17 
                 rs4925119 
                 17683629 
                 A 
                 0.345 
                 28218 
                 0.0000077 
                 1.16 
                 0.380 
                 2387 
                 0.0021 
                 1.10 
                 0.367 
                 3036 
               
               
                 C17 
                 rs3183702 
                 17688014 
                 T 
                 0.348 
                 28108 
                 0.0000041 
                 1.17 
                 0.384 
                 2388 
                 0.0013 
                 1.10 
                 0.371 
                 3038 
               
               
                 C17 
                 rs4925125 
                 17735169 
                 T 
                 0.353 
                 28060 
                 0.0000082 
                 1.16 
                 0.388 
                 2374 
                 0.0016 
                 1.10 
                 0.376 
                 3021 
               
               
                 C17 
                 rs6502622 
                 17775416 
                 G 
                 0.358 
                 28303 
                 0.0000065 
                 1.16 
                 0.393 
                 2395 
                 0.0019 
                 1.10 
                 0.380 
                 3047 
               
               
                 C17 
                 rs2955355 
                 17889200 
                 C 
                 0.285 
                 28312 
                 0.00000087 
                 1.19 
                 0.321 
                 2395 
                 0.00033 
                 1.12 
                 0.309 
                 3047 
               
               
                 C17 
                 rs854813 
                 17944570 
                 C 
                 0.385 
                 28182 
                 0.000011 
                 1.16 
                 0.420 
                 2393 
                 0.0031 
                 1.09 
                 0.406 
                 3042 
               
               
                 C17 
                 rs854793 
                 17971249 
                 A 
                 0.202 
                 28313 
                 0.000033 
                 1.18 
                 0.229 
                 2395 
                 0.0018 
                 1.12 
                 0.220 
                 3047 
               
               
                 C17 
                 rs854787 
                 17975744 
                 C 
                 0.400 
                 28104 
                 0.000046 
                 1.14 
                 0.432 
                 2381 
                 0.0046 
                 1.09 
                 0.420 
                 3028 
               
               
                 C17 
                 rs854771 
                 18000917 
                 C 
                 0.554 
                 28297 
                 0.00061 
                 1.12 
                 0.581 
                 2395 
                 0.00086 
                 1.10 
                 0.578 
                 3046 
               
               
                 C17 
                 rs2746025 
                 18092336 
                 G 
                 0.640 
                 28315 
                 0.0001 
                 1.14 
                 0.670 
                 2394 
                 0.0013 
                 1.11 
                 0.663 
                 3046 
               
               
                 C17 
                 rs9911448 
                 21030674 
                 C 
                 0.961 
                 28319 
                 0.023 
                 1.23 
                 0.968 
                 2395 
                 0.083 
                 1.15 
                 0.966 
                 3047 
               
               
                 C17 
                 rs7210156 
                 34250987 
                 G 
                 0.929 
                 28256 
                 0.0024 
                 1.23 
                 0.941 
                 2392 
                 0.019 
                 1.15 
                 0.937 
                 3043 
               
               
                 C17 
                 rs1122326 
                 37528399 
                 C 
                 0.242 
                 28309 
                 0.00086 
                 1.13 
                 0.265 
                 2395 
                 0.02 
                 1.08 
                 0.257 
                 3047 
               
               
                 C17 
                 rs12603327 
                 37544078 
                 C 
                 0.242 
                 28318 
                 0.00093 
                 1.13 
                 0.265 
                 2395 
                 0.021 
                 1.08 
                 0.256 
                 3047 
               
               
                 C17 
                 rs7214921 
                 37547551 
                 C 
                 0.242 
                 28291 
                 0.00095 
                 1.13 
                 0.265 
                 2394 
                 0.021 
                 1.08 
                 0.256 
                 3045 
               
               
                 C17 
                 rs4794128 
                 45727464 
                 A 
                 0.276 
                 28309 
                 0.0061 
                 1.10 
                 0.296 
                 2395 
                 0.0081 
                 1.09 
                 0.293 
                 3047 
               
               
                 C17 
                 rs11656018 
                 48969375 
                 C 
                 0.707 
                 28240 
                 0.0012 
                 1.13 
                 0.731 
                 2394 
                 0.002 
                 1.11 
                 0.728 
                 3045 
               
               
                 C17 
                 rs9895713 
                 50752149 
                 G 
                 0.178 
                 28297 
                 0.013 
                 1.11 
                 0.194 
                 2395 
                 0.03 
                 1.09 
                 0.191 
                 3047 
               
               
                 C17 
                 rs1985961 
                 59470994 
                 C 
                 0.413 
                 28311 
                 0.014 
                 1.09 
                 0.433 
                 2395 
                 0.0086 
                 1.08 
                 0.432 
                 3047 
               
               
                 C17 
                 rs312750 
                 65855134 
                 C 
                 0.548 
                 28314 
                 0.0018 
                 1.11 
                 0.573 
                 2395 
                 0.019 
                 1.07 
                 0.565 
                 3047 
               
               
                 C17 
                 rs9911654 
                 67172007 
                 T 
                 0.899 
                 28314 
                 0.0099 
                 1.16 
                 0.912 
                 2395 
                 0.037 
                 1.11 
                 0.908 
                 3047 
               
               
                 C17 
                 rs2041088 
                 67702720 
                 A 
                 0.722 
                 28312 
                 0.0041 
                 1.11 
                 0.743 
                 2395 
                 0.0028 
                 1.11 
                 0.741 
                 3047 
               
               
                 C17 
                 rs2159010 
                 67708572 
                 A 
                 0.730 
                 28262 
                 0.0097 
                 1.10 
                 0.748 
                 2395 
                 0.0053 
                 1.10 
                 0.748 
                 3045 
               
               
                 C17 
                 rs191227 
                 69202771 
                 A 
                 0.579 
                 28300 
                 0.022 
                 1.08 
                 0.597 
                 2394 
                 0.043 
                 1.06 
                 0.594 
                 3046 
               
               
                 C17 
                 rs1000299 
                 70660148 
                 A 
                 0.055 
                 28315 
                 0.0044 
                 1.21 
                 0.066 
                 2394 
                 0.015 
                 1.16 
                 0.063 
                 3046 
               
               
                 C17 
                 rs17674253 
                 74732189 
                 A 
                 0.583 
                 28311 
                 0.032 
                 1.07 
                 0.600 
                 2393 
                 0.071 
                 1.06 
                 0.596 
                 3045 
               
               
                 C18 
                 rs1791098 
                 3294629 
                 C 
                 0.763 
                 28318 
                 0.022 
                 1.09 
                 0.779 
                 2395 
                 0.24 
                 1.04 
                 0.770 
                 3047 
               
               
                 C18 
                 rs12964045 
                 13442635 
                 C 
                 0.131 
                 28312 
                 0.015 
                 1.12 
                 0.145 
                 2394 
                 0.031 
                 1.10 
                 0.142 
                 3046 
               
               
                 C18 
                 rs4271662 
                 26051291 
                 C 
                 0.587 
                 28256 
                 0.061 
                 1.06 
                 0.602 
                 2390 
                 0.092 
                 1.05 
                 0.599 
                 3039 
               
               
                 C18 
                 rs12964741 
                 35159625 
                 A 
                 0.668 
                 28119 
                 0.0049 
                 1.10 
                 0.689 
                 2359 
                 0.0013 
                 1.11 
                 0.690 
                 3008 
               
               
                 C18 
                 rs1015735 
                 39877321 
                 C 
                 0.267 
                 28220 
                 0.035 
                 1.08 
                 0.283 
                 2387 
                 0.15 
                 1.05 
                 0.277 
                 3037 
               
               
                 C18 
                 rs4340393 
                 39884052 
                 T 
                 0.266 
                 28320 
                 0.033 
                 1.08 
                 0.282 
                 2395 
                 0.13 
                 1.05 
                 0.276 
                 3047 
               
               
                 C18 
                 rs17734724 
                 43268749 
                 G 
                 0.276 
                 28318 
                 0.00071 
                 1.13 
                 0.300 
                 2395 
                 0.0024 
                 1.10 
                 0.296 
                 3047 
               
               
                 C18 
                 rs1790778 
                 45715039 
                 G 
                 0.512 
                 28314 
                 0.00027 
                 1.13 
                 0.541 
                 2394 
                 0.000024 
                 1.13 
                 0.543 
                 3046 
               
               
                 C18 
                 rs1557359 
                 45734896 
                 G 
                 0.408 
                 28317 
                 0.00063 
                 1.12 
                 0.435 
                 2395 
                 0.00016 
                 1.12 
                 0.435 
                 3047 
               
               
                 C18 
                 rs634285 
                 53273824 
                 G 
                 0.913 
                 11415 
                 0.00075 
                 1.28 
                 0.930 
                 1775 
                 0.0036 
                 1.22 
                 0.927 
                 2094 
               
               
                 C18 
                 rs580647 
                 53284831 
                 A 
                 0.886 
                 28267 
                 0.034 
                 1.12 
                 0.897 
                 2394 
                 0.057 
                 1.09 
                 0.895 
                 3045 
               
               
                 C18 
                 rs4940582 
                 53743264 
                 G 
                 0.851 
                 28314 
                 0.0016 
                 1.16 
                 0.869 
                 2394 
                 0.0016 
                 1.14 
                 0.867 
                 3046 
               
               
                 C18 
                 rs657773 
                 55097571 
                 C 
                 0.556 
                 28318 
                 0.00062 
                 1.12 
                 0.583 
                 2395 
                 0.012 
                 1.08 
                 0.574 
                 3047 
               
               
                 C18 
                 rs4806 
                 55146376 
                 C 
                 0.285 
                 28175 
                 0.016 
                 1.09 
                 0.303 
                 2376 
                 0.049 
                 1.07 
                 0.299 
                 3025 
               
               
                 C18 
                 rs9319948 
                 55193376 
                 A 
                 0.285 
                 28174 
                 0.025 
                 1.08 
                 0.302 
                 2387 
                 0.074 
                 1.06 
                 0.297 
                 3033 
               
               
                 C18 
                 rs8088514 
                 55213078 
                 C 
                 0.461 
                 28276 
                 0.0093 
                 1.09 
                 0.482 
                 2386 
                 0.037 
                 1.06 
                 0.476 
                 3038 
               
               
                 C18 
                 rs8082768 
                 55792708 
                 T 
                 0.182 
                 28281 
                 0.007 
                 1.12 
                 0.200 
                 2390 
                 0.01 
                 1.10 
                 0.197 
                 3040 
               
               
                 C18 
                 rs9948303 
                 55911746 
                 G 
                 0.102 
                 28316 
                 0.084 
                 1.10 
                 0.110 
                 2395 
                 0.0079 
                 1.13 
                 0.114 
                 3047 
               
               
                 C18 
                 rs603119 
                 56407631 
                 T 
                 0.391 
                 28278 
                 0.072 
                 1.06 
                 0.406 
                 2394 
                 0.021 
                 1.07 
                 0.408 
                 3045 
               
               
                 C18 
                 rs2332026 
                 56572162 
                 A 
                 0.505 
                 28318 
                 0.059 
                 1.06 
                 0.520 
                 2395 
                 0.051 
                 1.06 
                 0.519 
                 3047 
               
               
                 C18 
                 rs3744927 
                 58396227 
                 G 
                 0.772 
                 28317 
                 0.0024 
                 1.13 
                 0.793 
                 2395 
                 0.017 
                 1.09 
                 0.787 
                 3047 
               
               
                 C18 
                 rs2332575 
                 58449327 
                 A 
                 0.054 
                 28302 
                 0.014 
                 1.18 
                 0.064 
                 2392 
                 0.028 
                 1.15 
                 0.062 
                 3044 
               
               
                 C18 
                 rs7241455 
                 58476248 
                 T 
                 0.063 
                 28318 
                 0.0045 
                 1.20 
                 0.075 
                 2395 
                 0.0039 
                 1.18 
                 0.074 
                 3047 
               
               
                 C18 
                 rs12458349 
                 58505190 
                 G 
                 0.061 
                 28155 
                 0.0014 
                 1.23 
                 0.074 
                 2389 
                 0.0013 
                 1.21 
                 0.073 
                 3036 
               
               
                 C18 
                 rs1365254 
                 70238283 
                 T 
                 0.196 
                 28319 
                 0.066 
                 1.08 
                 0.208 
                 2395 
                 0.036 
                 1.08 
                 0.209 
                 3047 
               
               
                 C18 
                 rs4892210 
                 70241069 
                 A 
                 0.196 
                 28316 
                 0.057 
                 1.08 
                 0.209 
                 2395 
                 0.031 
                 1.08 
                 0.209 
                 3047 
               
               
                 C18 
                 rs2850889 
                 73087595 
                 C 
                 0.409 
                 28316 
                 0.00013 
                 1.13 
                 0.440 
                 2395 
                 0.00015 
                 1.12 
                 0.437 
                 3046 
               
               
                 C18 
                 rs2156643 
                 73088668 
                 G 
                 0.409 
                 28304 
                 0.00013 
                 1.13 
                 0.440 
                 2395 
                 0.00015 
                 1.12 
                 0.436 
                 3047 
               
               
                 C18 
                 rs2850892 
                 73088829 
                 C 
                 0.409 
                 28292 
                 0.00014 
                 1.13 
                 0.440 
                 2393 
                 0.00016 
                 1.12 
                 0.436 
                 3043 
               
               
                 C19 
                 rs10414677 
                 330003 
                 T 
                 0.285 
                 27883 
                 0.048 
                 1.07 
                 0.299 
                 2322 
                 0.27 
                 1.04 
                 0.292 
                 2956 
               
               
                 C19 
                 rs758503 
                 446722 
                 T 
                 0.302 
                 27981 
                 0.012 
                 1.09 
                 0.321 
                 2371 
                 0.011 
                 1.08 
                 0.319 
                 3018 
               
               
                 C19 
                 rs4740 
                 4187996 
                 A 
                 0.274 
                 28312 
                 0.017 
                 1.09 
                 0.291 
                 2395 
                 0.054 
                 1.07 
                 0.286 
                 3047 
               
               
                 C19 
                 rs1045750 
                 4202069 
                 C 
                 0.269 
                 28318 
                 0.021 
                 1.09 
                 0.286 
                 2394 
                 0.054 
                 1.07 
                 0.281 
                 3046 
               
               
                 C19 
                 rs4807567 
                 4229502 
                 T 
                 0.427 
                 28263 
                 0.07 
                 1.06 
                 0.442 
                 2394 
                 0.07 
                 1.06 
                 0.441 
                 3045 
               
               
                 C19 
                 rs10419363 
                 4231186 
                 T 
                 0.306 
                 28279 
                 0.076 
                 1.06 
                 0.319 
                 2390 
                 0.069 
                 1.06 
                 0.318 
                 3040 
               
               
                 C19 
                 rs10406508 
                 8795907 
                 T 
                 0.764 
                 11415 
                 0.0031 
                 1.15 
                 0.788 
                 1775 
                 0.0092 
                 1.12 
                 0.784 
                 2094 
               
               
                 C19 
                 rs7248277 
                 14236895 
                 C 
                 0.570 
                 28306 
                 0.0065 
                 1.09 
                 0.592 
                 2394 
                 0.0034 
                 1.09 
                 0.591 
                 3045 
               
               
                 C19 
                 rs2305758 
                 17024661 
                 G 
                 0.691 
                 28308 
                 0.0044 
                 1.11 
                 0.712 
                 2394 
                 0.0026 
                 1.10 
                 0.711 
                 3046 
               
               
                 C19 
                 rs2278997 
                 17027981 
                 T 
                 0.229 
                 28315 
                 0.0000018 
                 1.20 
                 0.262 
                 2395 
                 0.0000088 
                 1.16 
                 0.257 
                 3047 
               
               
                 C19 
                 rs12459084 
                 17031885 
                 T 
                 0.350 
                 27962 
                 0.00013 
                 1.14 
                 0.380 
                 2387 
                 0.002 
                 1.10 
                 0.372 
                 3037 
               
               
                 C19 
                 rs7254154 
                 17039119 
                 C 
                 0.352 
                 28271 
                 0.00019 
                 1.13 
                 0.381 
                 2389 
                 0.0028 
                 1.10 
                 0.373 
                 3041 
               
               
                 C19 
                 rs7246865 
                 17080105 
                 A 
                 0.205 
                 28321 
                 0.00016 
                 1.16 
                 0.230 
                 2395 
                 0.00025 
                 1.14 
                 0.227 
                 3047 
               
               
                 C19 
                 rs4933027 
                 22695812 
                 T 
                 0.083 
                 28318 
                 0.00019 
                 1.23 
                 0.101 
                 2395 
                 0.0011 
                 1.18 
                 0.097 
                 3047 
               
               
                 C19 
                 rs4805463 
                 34828875 
                 G 
                 0.909 
                 28316 
                 0.0018 
                 1.20 
                 0.923 
                 2395 
                 0.0073 
                 1.15 
                 0.920 
                 3047 
               
               
                 C19 
                 rs346535 
                 48943265 
                 T 
                 0.234 
                 28317 
                 0.0031 
                 1.12 
                 0.255 
                 2395 
                 0.00078 
                 1.12 
                 0.255 
                 3047 
               
               
                 C19 
                 rs377702 
                 50054507 
                 T 
                 0.391 
                 28304 
                 0.007 
                 1.09 
                 0.412 
                 2395 
                 0.014 
                 1.08 
                 0.409 
                 3047 
               
               
                 C19 
                 rs3760802 
                 53768499 
                 A 
                 0.505 
                 28309 
                 0.073 
                 1.06 
                 0.519 
                 2392 
                 0.13 
                 1.05 
                 0.516 
                 3044 
               
               
                 C19 
                 rs11668495 
                 58638423 
                 C 
                 0.940 
                 28270 
                 0.065 
                 1.14 
                 0.947 
                 2392 
                 0.12 
                 1.11 
                 0.945 
                 3044 
               
               
                 C19 
                 rs8113561 
                 62070079 
                 G 
                 0.954 
                 28311 
                 0.0055 
                 1.26 
                 0.963 
                 2395 
                 0.025 
                 1.18 
                 0.960 
                 3047 
               
               
                 C20 
                 rs723477 
                 237362 
                 T 
                 0.742 
                 28284 
                 0.004 
                 1.12 
                 0.762 
                 2389 
                 0.0029 
                 1.11 
                 0.761 
                 3040 
               
               
                 C20 
                 rs1741285 
                 4064436 
                 G 
                 0.560 
                 28300 
                 0.00075 
                 1.12 
                 0.588 
                 2392 
                 0.00072 
                 1.11 
                 0.585 
                 3043 
               
               
                 C20 
                 rs6084644 
                 4069799 
                 G 
                 0.437 
                 28319 
                 0.00096 
                 1.11 
                 0.464 
                 2395 
                 0.00062 
                 1.11 
                 0.462 
                 3047 
               
               
                 C20 
                 rs6076623 
                 4084671 
                 T 
                 0.367 
                 28302 
                 0.000045 
                 1.15 
                 0.399 
                 2395 
                 0.0000036 
                 1.15 
                 0.400 
                 3047 
               
               
                 C20 
                 rs1741315 
                 4103948 
                 A 
                 0.484 
                 28317 
                 0.0014 
                 1.11 
                 0.510 
                 2395 
                 0.0012 
                 1.10 
                 0.508 
                 3047 
               
               
                 C20 
                 rs1741318 
                 4105600 
                 A 
                 0.450 
                 28315 
                 0.0025 
                 1.10 
                 0.474 
                 2394 
                 0.0013 
                 1.10 
                 0.473 
                 3046 
               
               
                 C20 
                 rs236110 
                 5881108 
                 G 
                 0.871 
                 28299 
                 0.00079 
                 1.19 
                 0.889 
                 2393 
                 0.0036 
                 1.14 
                 0.885 
                 3044 
               
               
                 C20 
                 rs236113 
                 5882566 
                 T 
                 0.883 
                 28321 
                 0.001 
                 1.19 
                 0.900 
                 2395 
                 0.0063 
                 1.14 
                 0.896 
                 3047 
               
               
                 C20 
                 rs2026058 
                 13639900 
                 T 
                 0.768 
                 28319 
                 0.048 
                 1.08 
                 0.781 
                 2395 
                 0.084 
                 1.06 
                 0.779 
                 3047 
               
               
                 C20 
                 rs6079235 
                 13886789 
                 C 
                 0.736 
                 28308 
                 0.096 
                 1.06 
                 0.748 
                 2394 
                 0.12 
                 1.05 
                 0.746 
                 3046 
               
               
                 C20 
                 rs411944 
                 15006882 
                 G 
                 0.651 
                 28275 
                 0.0033 
                 1.11 
                 0.673 
                 2392 
                 0.035 
                 1.07 
                 0.665 
                 3044 
               
               
                 C20 
                 rs6034134 
                 15182479 
                 G 
                 0.596 
                 28318 
                 0.026 
                 1.08 
                 0.614 
                 2395 
                 0.065 
                 1.06 
                 0.610 
                 3047 
               
               
                 C20 
                 rs199812 
                 22264552 
                 C 
                 0.888 
                 28288 
                 0.0074 
                 1.15 
                 0.902 
                 2394 
                 0.0026 
                 1.16 
                 0.902 
                 3046 
               
               
                 C20 
                 rs734484 
                 31943651 
                 C 
                 0.713 
                 28316 
                 0.079 
                 1.07 
                 0.726 
                 2394 
                 0.1 
                 1.06 
                 0.724 
                 3045 
               
               
                 C20 
                 rs981303 
                 45947245 
                 A 
                 0.931 
                 28301 
                 0.057 
                 1.14 
                 0.939 
                 2391 
                 0.011 
                 1.17 
                 0.941 
                 3043 
               
               
                 C20 
                 rs4811008 
                 48277796 
                 G 
                 0.463 
                 27959 
                 0.00032 
                 1.13 
                 0.493 
                 2348 
                 0.0065 
                 1.09 
                 0.483 
                 2993 
               
               
                 C20 
                 rs913670 
                 48339923 
                 C 
                 0.634 
                 28276 
                 0.00081 
                 1.12 
                 0.660 
                 2395 
                 0.0051 
                 1.09 
                 0.654 
                 3046 
               
               
                 C20 
                 rs913673 
                 48341447 
                 C 
                 0.541 
                 28304 
                 0.00017 
                 1.13 
                 0.571 
                 2395 
                 0.0029 
                 1.09 
                 0.563 
                 3047 
               
               
                 C20 
                 rs6068930 
                 52700213 
                 G 
                 0.040 
                 28199 
                 0.013 
                 1.22 
                 0.048 
                 2389 
                 0.021 
                 1.18 
                 0.046 
                 3039 
               
               
                 C20 
                 rs486921 
                 56349782 
                 C 
                 0.854 
                 28319 
                 0.0042 
                 1.15 
                 0.870 
                 2394 
                 0.013 
                 1.11 
                 0.867 
                 3046 
               
               
                 C20 
                 rs6128327 
                 56375963 
                 A 
                 0.647 
                 27522 
                 0.029 
                 1.08 
                 0.664 
                 2355 
                 0.079 
                 1.06 
                 0.660 
                 2992 
               
               
                 C20 
                 rs6128397 
                 56686538 
                 G 
                 0.690 
                 28315 
                 0.012 
                 1.09 
                 0.708 
                 2395 
                 0.031 
                 1.07 
                 0.704 
                 3047 
               
               
                 C20 
                 rs6128843 
                 58519280 
                 T 
                 0.183 
                 28319 
                 0.00057 
                 1.15 
                 0.205 
                 2395 
                 0.0027 
                 1.12 
                 0.201 
                 3047 
               
               
                 C21 
                 rs2822391 
                 14334270 
                 A 
                 0.553 
                 28310 
                 0.021 
                 1.08 
                 0.572 
                 2394 
                 0.0088 
                 1.08 
                 0.572 
                 3045 
               
               
                 C21 
                 rs2822744 
                 14821123 
                 A 
                 0.158 
                 28318 
                 0.026 
                 1.10 
                 0.171 
                 2395 
                 0.045 
                 1.08 
                 0.169 
                 3047 
               
               
                 C21 
                 rs2822753 
                 14824849 
                 G 
                 0.356 
                 28297 
                 0.057 
                 1.07 
                 0.371 
                 2394 
                 0.13 
                 1.05 
                 0.367 
                 3046 
               
               
                 C21 
                 rs1349227 
                 16738666 
                 T 
                 0.242 
                 28301 
                 0.018 
                 1.09 
                 0.258 
                 2393 
                 0.021 
                 1.08 
                 0.256 
                 3045 
               
               
                 C21 
                 rs2017705 
                 21803122 
                 C 
                 0.074 
                 28287 
                 0.0091 
                 1.17 
                 0.085 
                 2390 
                 0.058 
                 1.11 
                 0.081 
                 3041 
               
               
                 C21 
                 rs2828495 
                 24038081 
                 A 
                 0.212 
                 28316 
                 0.001 
                 1.14 
                 0.234 
                 2395 
                 0.00089 
                 1.12 
                 0.232 
                 3047 
               
               
                 C21 
                 rs2828515 
                 24056599 
                 G 
                 0.124 
                 28296 
                 0.0093 
                 1.13 
                 0.138 
                 2394 
                 0.0024 
                 1.14 
                 0.139 
                 3046 
               
               
                 C21 
                 rs2829040 
                 24693776 
                 A 
                 0.452 
                 28251 
                 0.047 
                 1.07 
                 0.468 
                 2392 
                 0.23 
                 1.04 
                 0.460 
                 3044 
               
               
                 C21 
                 rs2830357 
                 26972748 
                 G 
                 0.575 
                 28313 
                 0.0019 
                 1.11 
                 0.600 
                 2395 
                 0.0025 
                 1.10 
                 0.597 
                 3046 
               
               
                 C21 
                 rs2251540 
                 26986173 
                 G 
                 0.651 
                 28262 
                 0.0027 
                 1.11 
                 0.674 
                 2391 
                 0.0089 
                 1.09 
                 0.669 
                 3042 
               
               
                 C21 
                 rs1882757 
                 40711890 
                 A 
                 0.507 
                 28320 
                 0.079 
                 1.06 
                 0.522 
                 2393 
                 0.068 
                 1.06 
                 0.521 
                 3045 
               
               
                 C21 
                 rs3788014 
                 42722104 
                 C 
                 0.925 
                 28314 
                 0.0012 
                 1.24 
                 0.938 
                 2395 
                 0.0019 
                 1.20 
                 0.937 
                 3046 
               
               
                 C22 
                 rs2019061 
                 17343340 
                 T 
                 0.689 
                 28294 
                 0.01 
                 1.10 
                 0.708 
                 2388 
                 0.0051 
                 1.09 
                 0.708 
                 3038 
               
               
                 C22 
                 rs1978058 
                 18288219 
                 T 
                 0.372 
                 28137 
                 0.000015 
                 1.16 
                 0.406 
                 2388 
                 0.00038 
                 1.11 
                 0.397 
                 3034 
               
               
                 C22 
                 rs3804044 
                 18432442 
                 T 
                 0.858 
                 28284 
                 0.0037 
                 1.15 
                 0.875 
                 2395 
                 0.0039 
                 1.13 
                 0.873 
                 3046 
               
               
                 C22 
                 rs5992507 
                 18437458 
                 A 
                 0.859 
                 28309 
                 0.004 
                 1.15 
                 0.875 
                 2395 
                 0.0042 
                 1.13 
                 0.873 
                 3047 
               
               
                 C22 
                 rs2073778 
                 18454575 
                 C 
                 0.858 
                 28316 
                 0.0036 
                 1.15 
                 0.875 
                 2395 
                 0.0046 
                 1.13 
                 0.873 
                 3047 
               
               
                 C22 
                 rs2238798 
                 18487729 
                 G 
                 0.859 
                 28289 
                 0.0045 
                 1.15 
                 0.875 
                 2394 
                 0.0057 
                 1.13 
                 0.873 
                 3044 
               
               
                 C22 
                 rs178260 
                 19654308 
                 T 
                 0.142 
                 28310 
                 0.029 
                 1.10 
                 0.154 
                 2395 
                 0.039 
                 1.09 
                 0.152 
                 3047 
               
               
                 C22 
                 rs430305 
                 19688522 
                 T 
                 0.829 
                 28319 
                 0.0096 
                 1.12 
                 0.844 
                 2395 
                 0.038 
                 1.09 
                 0.840 
                 3047 
               
               
                 C22 
                 rs8135273 
                 32527802 
                 C 
                 0.157 
                 28046 
                 0.025 
                 1.10 
                 0.170 
                 2369 
                 0.057 
                 1.08 
                 0.167 
                 3012 
               
               
                 C22 
                 rs2267296 
                 32549939 
                 G 
                 0.444 
                 28313 
                 0.0015 
                 1.11 
                 0.470 
                 2394 
                 0.00076 
                 1.10 
                 0.469 
                 3046 
               
               
                 C22 
                 rs2071744 
                 34147553 
                 C 
                 0.782 
                 28278 
                 0.012 
                 1.11 
                 0.798 
                 2394 
                 0.038 
                 1.08 
                 0.794 
                 3044 
               
               
                 C22 
                 rs132717 
                 34926598 
                 C 
                 0.618 
                 28303 
                 0.069 
                 1.06 
                 0.633 
                 2395 
                 0.56 
                 1.02 
                 0.622 
                 3047 
               
               
                 C22 
                 rs7364143 
                 34932129 
                 T 
                 0.279 
                 28278 
                 0.00042 
                 1.13 
                 0.305 
                 2391 
                 0.0024 
                 1.10 
                 0.299 
                 3043 
               
               
                 C22 
                 rs5995259 
                 34941809 
                 A 
                 0.338 
                 28320 
                 0.00058 
                 1.12 
                 0.365 
                 2395 
                 0.004 
                 1.09 
                 0.358 
                 3047 
               
               
                 C22 
                 rs763086 
                 34949003 
                 A 
                 0.301 
                 28254 
                 0.0059 
                 1.10 
                 0.322 
                 2391 
                 0.014 
                 1.08 
                 0.318 
                 3038 
               
               
                 C22 
                 rs738407 
                 42655288 
                 A 
                 0.640 
                 28301 
                 0.0014 
                 1.12 
                 0.664 
                 2394 
                 0.0018 
                 1.10 
                 0.662 
                 3046 
               
               
                 C22 
                 rs739164 
                 45063222 
                 A 
                 0.892 
                 27998 
                 0.0056 
                 1.17 
                 0.906 
                 2330 
                 0.018 
                 1.12 
                 0.903 
                 2978 
               
               
                 CX 
                 rs6638525 
                 5464517 
                 C 
                 0.110 
                 22852 
                 0.016 
                 1.16 
                 0.126 
                 1545 
                 0.017 
                 1.14 
                 0.124 
                 1962 
               
               
                 CX 
                 rs1919026 
                 5471853 
                 C 
                 0.195 
                 22929 
                 0.04 
                 1.11 
                 0.212 
                 1550 
                 0.22 
                 1.06 
                 0.204 
                 1967 
               
               
                 CX 
                 rs7892324 
                 6679297 
                 C 
                 0.167 
                 22905 
                 0.0011 
                 1.19 
                 0.192 
                 1542 
                 0.005 
                 1.14 
                 0.186 
                 1956 
               
               
                 CX 
                 rs3013140 
                 41283447 
                 G 
                 0.933 
                 22939 
                 0.042 
                 1.19 
                 0.943 
                 1551 
                 0.037 
                 1.17 
                 0.943 
                 1968 
               
               
                 CX 
                 rs5914778 
                 56774956 
                 G 
                 0.804 
                 22928 
                 0.002 
                 1.18 
                 0.828 
                 1550 
                 0.0032 
                 1.15 
                 0.825 
                 1966 
               
               
                 CX 
                 rs2031751 
                 67165559 
                 C 
                 0.941 
                 22937 
                 0.08 
                 1.17 
                 0.949 
                 1550 
                 0.051 
                 1.17 
                 0.949 
                 1967 
               
               
                 CX 
                 rs1576059 
                 67171306 
                 T 
                 0.941 
                 22937 
                 0.076 
                 1.17 
                 0.949 
                 1551 
                 0.056 
                 1.17 
                 0.949 
                 1968 
               
               
                 CX 
                 rs7050085 
                 67278825 
                 G 
                 0.908 
                 22941 
                 0.015 
                 1.19 
                 0.922 
                 1550 
                 0.0059 
                 1.20 
                 0.922 
                 1967 
               
               
                 CX 
                 rs2341629 
                 70367614 
                 C 
                 0.470 
                 22923 
                 0.093 
                 1.07 
                 0.487 
                 1550 
                 0.16 
                 1.05 
                 0.483 
                 1967 
               
               
                 CX 
                 rs2213468 
                 86099449 
                 G 
                 0.668 
                 22877 
                 0.047 
                 1.09 
                 0.687 
                 1541 
                 0.15 
                 1.06 
                 0.680 
                 1958 
               
               
                 CX 
                 rs6615536 
                 92662125 
                 G 
                 0.988 
                 22935 
                 0.0094 
                 1.77 
                 0.993 
                 1551 
                 0.00098 
                 1.97 
                 0.994 
                 1968 
               
               
                 CX 
                 rs2227165 
                 92880063 
                 C 
                 0.899 
                 8732 
                 0.00000074 
                 1.56 
                 0.933 
                 1121 
                 0.00013 
                 1.37 
                 0.924 
                 1314 
               
               
                 CX 
                 rs3788769 
                 109423718 
                 C 
                 0.441 
                 22401 
                 0.0016 
                 1.14 
                 0.473 
                 1534 
                 0.0018 
                 1.12 
                 0.470 
                 1944 
               
               
                 CX 
                 rs2526763 
                 116328390 
                 G 
                 0.365 
                 22923 
                 0.006 
                 1.12 
                 0.392 
                 1549 
                 0.0083 
                 1.10 
                 0.388 
                 1965 
               
               
                 CX 
                 rs1948488 
                 139835516 
                 A 
                 0.222 
                 22466 
                 0.043 
                 1.10 
                 0.239 
                 1527 
                 0.02 
                 1.11 
                 0.240 
                 1937 
               
               
                 CX 
                 rs11094472 
                 144273211 
                 G 
                 0.787 
                 22928 
                 0.00017 
                 1.21 
                 0.818 
                 1545 
                 0.004 
                 1.14 
                 0.808 
                 1962 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 4 
               
               
                   
               
               
                 Results of replication analysis in several populations. A total of 100 markers from 
               
               
                 the genome-wide scan shown in Table 3 were selected for replication. The table shows results 
               
               
                 of replication in cohorts from Atlanta and Durham (A - MI; B - CAD), Durham and Italy (C - 
               
               
                 MI; D - CAD), John Hopkins, WTCCC and in combined replication samples (E - MI; F - CAD), 
               
               
                 and results for the Icelandic discovery cohort and combined analysis for all the cohorts (G - 
               
               
                 MI; H - CAD). The number of controls/cases is shown for each analysis. 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 Table 4A - MI 
                 Atlanta (1273/646) 
                 Philadelphia (497/570) 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Chr 
                 SNP 
                 Pos_B36 
                 Allele 
                 nc/na 
                 Ctr. fr 
                 Aff. fr 
                 OR 
                 P 
                 nc/na 
                 Ctr. fr 
                 Aff. fr 
                 OR 
                 P 
               
               
                   
               
               
                 C06 
                 rs11751605 
                 160883220 
                 C 
                 1273/643 
                 0.155 
                 0.163 
                 1.06 
                 0.53 
                 497/566 
                 0.131 
                 0.135 
                 1.04 
                 0.77 
               
               
                 C10 
                 rs2243547 
                 91000459 
                 G 
               
               
                 C10 
                 rs1412444 
                 90992907 
                 A 
                  581/367 
                 0.333 
                 0.356 
                 1.10 
                 0.31 
                 496/570 
                 0.326 
                 0.353 
                 1.13 
                 0.19 
               
               
                 C01 
                 rs12134779 
                 63168930 
                 T 
                 1260/578 
                 0.285 
                 0.289 
                 1.02 
                 0.78 
                 497/567 
                 0.270 
                 0.271 
                 1.01 
                 0.95 
               
               
                 C11 
                 rs2163612 
                 82856844 
                 G 
                  513/367 
                 0.496 
                 0.499 
                 1.01 
                 0.92 
                 465/522 
                 0.488 
                 0.513 
                 1.11 
                 0.26 
               
               
                 C05 
                 rs254850 
                 158599309 
                 T 
               
               
                 C17 
                 rs9902941 
                 17674485 
                 C 
                 1210/591 
                 0.352 
                 0.372 
                 1.09 
                 0.25 
                 474/542 
                 0.393 
                 0.423 
                 1.13 
                 0.17 
               
               
                 C20 
                 rs6076623 
                 4084671 
                 T 
                 1246/621 
                 0.303 
                 0.335 
                 1.16 
                 0.051 
                 494/562 
                 0.283 
                 0.276 
                 0.96 
                 0.7 
               
               
                 C05 
                 rs4921437 
                 158623529 
                 T 
               
               
                 C05 
                 rs832540 
                 56234959 
                 C 
               
               
                 C19 
                 rs12459084 
                 17031885 
                 T 
               
               
                 C07 
                 rs1029396 
                 116812056 
                 G 
                  572/363 
                 0.082 
                 0.094 
                 1.15 
                 0.39 
                 491/562 
                 0.074 
                 0.070 
                 0.94 
                 0.72 
               
               
                 C17 
                 rs6502622 
                 17775416 
                 G 
                 1227/593 
                 0.366 
                 0.401 
                 1.16 
                 0.042 
                 475/540 
                 0.409 
                 0.433 
                 1.10 
                 0.28 
               
               
                 C17 
                 rs854787 
                 17975744 
                 C 
                  507/360 
                 0.399 
                 0.475 
                 1.36 
                 0.0017 
                 475/542 
                 0.433 
                 0.458 
                 1.11 
                 0.24 
               
               
                 C14 
                 rs7158073 
                 99211442 
                 T 
                  575/362 
                 0.408 
                 0.419 
                 1.04 
                 0.65 
                 480/549 
                 0.426 
                 0.448 
                 1.09 
                 0.31 
               
               
                 C10 
                 rs2243548 
                 91000293 
                 A 
               
               
                 C17 
                 rs4925119 
                 17683629 
                 A 
                 1207/646 
                 0.349 
                 0.372 
                 1.11 
                 0.16 
                 470/537 
                 0.397 
                 0.419 
                 1.10 
                 0.31 
               
               
                 C17 
                 rs3183702 
                 17688014 
                 T 
                  539/362 
                 0.337 
                 0.391 
                 1.26 
                 0.019 
                 469/531 
                 0.393 
                 0.427 
                 1.15 
                 0.13 
               
               
                 C17 
                 rs854813 
                 17944570 
                 C 
                  539/364 
                 0.388 
                 0.449 
                 1.29 
                 0.0094 
                 462/520 
                 0.429 
                 0.468 
                 1.17 
                 0.077 
               
               
                 C05 
                 rs953861 
                 158705160 
                 G 
               
               
                 C07 
                 rs12534186 
                 117079572 
                 T 
               
               
                 C12 
                 rs2417821 
                 20081535 
                 T 
               
               
                 C20 
                 rs1741318 
                 4105600 
                 A 
               
               
                 C06 
                 rs2074464 
                 29516507 
                 T 
                  576/365 
                 0.442 
                 0.484 
                 1.18 
                 0.077 
                 491/554 
                 0.486 
                 0.464 
                 0.92 
                 0.32 
               
               
                 C07 
                 rs324594 
                 136305863 
                 C 
               
               
                 C05 
                 rs270654 
                 158497687 
                 G 
               
               
                 C15 
                 rs4779984 
                 30302218 
                 G 
               
               
                 C05 
                 rs7709212 
                 158696755 
                 T 
               
               
                 C05 
                 rs10045431 
                 158747111 
                 A 
               
               
                 C17 
                 rs2955355 
                 17889200 
                 C 
                  534/360 
                 0.291 
                 0.360 
                 1.37 
                 0.0024 
                 476/544 
                 0.352 
                 0.362 
                 1.05 
                 0.63 
               
               
                 C11 
                 rs7944761 
                 1361414 
                 T 
               
               
                 C05 
                 rs4704400 
                 76586766 
                 T 
                   
                   
                   
                   
                   
                 416/485 
                 0.460 
                 0.468 
                 1.03 
                 0.74 
               
               
                 C17 
                 rs4925114 
                 17651995 
                 A 
                  521/361 
                 0.343 
                 0.378 
                 1.17 
                 0.13 
                 473/539 
                 0.403 
                 0.400 
                 0.99 
                 0.89 
               
               
                 C05 
                 rs1433048 
                 158688423 
                 G 
               
               
                 C05 
                 rs7447732 
                 158461713 
                 C 
                 1225/544 
                 0.315 
                 0.312 
                 0.99 
                 0.85 
                 497/567 
                 0.272 
                 0.311 
                 1.21 
                 0.045 
               
               
                 C02 
                 rs2244871 
                 128115310 
                 C 
                  500/349 
                 0.431 
                 0.430 
                 1.00 
                 0.96 
                 456/509 
                 0.459 
                 0.449 
                 0.96 
                 0.64 
               
               
                 C01 
                 rs2946534 
                 18647370 
                 T 
               
               
                 C04 
                 rs7661204 
                 45728C07 
                 T 
               
               
                 C05 
                 rs6556861 
                 94554256 
                 G 
               
               
                 C06 
                 rs7753765 
                 71732495 
                 A 
                  532/366 
                 0.172 
                 0.182 
                 1.07 
                 0.6 
                 479/533 
                 0.175 
                 0.174 
                 0.99 
                 0.96 
               
               
                 C05 
                 rs870347 
                 6898035 
                 T 
               
               
                 C10 
                 rs12269612 
                 15475877 
                 T 
               
               
                 C15 
                 rs2110209 
                 24946433 
                 A 
               
               
                 C02 
                 rs12329252 
                 212093968 
                 T 
                 1250/554 
                 0.681 
                 0.680 
                 0.99 
                 0.94 
                 492/569 
                 0.682 
                 0.683 
                 1.00 
                 0.97 
               
               
                 C14 
                 rs8003722 
                 68388015 
                 A 
                 1029/472 
                 0.147 
                 0.151 
                 1.04 
                 0.73 
               
               
                 C21 
                 rs2828495 
                 24038081 
                 A 
               
               
                 C05 
                 rs270661 
                 158492732 
                 A 
               
               
                 C08 
                 rs334198 
                 18933089 
                 C 
                  542/367 
                 0.918 
                 0.914 
                 0.95 
                 0.78 
                 475/543 
                 0.900 
                 0.912 
                 1.15 
                 0.37 
               
               
                 C01 
                 rs2476601 
                 114179091 
                 A 
                 1188/280 
                 0.093 
                 0.113 
                 1.23 
                 0.18 
                 462/540 
                 0.093 
                 0.096 
                 1.04 
                 0.81 
               
               
                 C13 
                 rs4769613 
                 28036609 
                 T 
               
               
                 C08 
                 rs3102526 
                 96858538 
                 G 
               
               
                 C08 
                 rs3134517 
                 96859237 
                 G 
               
               
                 C01 
                 rs3748744 
                 19828833 
                 G 
               
               
                 C04 
                 rs4282162 
                 21426819 
                 T 
               
               
                 C16 
                 rs8050136 
                 52373776 
                 A 
                   
                   
                   
                   
                   
                 488/561 
                 0.408 
                 0.415 
                 1.03 
                 0.73 
               
               
                 C16 
                 rs3751812 
                 52375961 
                 T 
                   
                   
                   
                   
                   
                 490/567 
                 0.397 
                 0.405 
                 1.03 
                 0.71 
               
               
                 C17 
                 rs854793 
                 17971249 
                 A 
                  539/369 
                 0.213 
                 0.255 
                 1.26 
                 0.04 
                 454/505 
                 0.246 
                 0.260 
                 1.08 
                 0.46 
               
               
                 C10 
                 rs4880711 
                 5217871 
                 C 
               
               
                 C12 
                 rs12304836 
                 124654446 
                 C 
                 1217/588 
                 0.152 
                 0.151 
                 0.99 
                 0.88 
                 472/532 
                 0.145 
                 0.173 
                 1.23 
                 0.089 
               
               
                 C05 
                 rs38055 
                 52596401 
                 T 
                 1259/556 
                 0.311 
                 0.341 
                 1.15 
                 0.072 
                 491/565 
                 0.305 
                 0.340 
                 1.17 
                 0.092 
               
               
                 C09 
                 rs2297538 
                 138684489 
                 G 
                   
                   
                   
                   
                   
                 404/454 
                 0.786 
                 0.739 
                 0.77 
                 0.023 
               
               
                 C16 
                 rs1870843 
                 81316815 
                 T 
               
               
                 C06 
                 rs6905466 
                 19958854 
                 T 
               
               
                 C12 
                 rs11045689 
                 21092930 
                 G 
                 1196/419 
                 0.345 
                 0.344 
                 0.99 
                 0.95 
                 492/556 
                 0.362 
                 0.346 
                 0.93 
                 0.46 
               
               
                 C13 
                 rs1887263 
                 22381716 
                 A 
               
               
                 C18 
                 rs4271662 
                 26051291 
                 C 
                 1216/551 
                 0.598 
                 0.613 
                 1.07 
                 0.38 
                 487/553 
                 0.611 
                 0.613 
                 1.01 
                 0.92 
               
               
                 C18 
                 rs1365254 
                 70238283 
                 T 
               
               
                 C06 
                 rs3016536 
                 162157939 
                 G 
               
               
                 C12 
                 rs3742049 
                 119438873 
                 C 
                  584/364 
                 0.901 
                 0.905 
                 1.05 
                 0.75 
               
               
                 C03 
                 rs9874646 
                 62437858 
                 T 
                 1193/414 
                 0.684 
                 0.687 
                 1.01 
                 0.86 
                 492/559 
                 0.648 
                 0.678 
                 1.14 
                 0.15 
               
               
                 C14 
                 rs2281519 
                 93846385 
                 T 
               
               
                 C02 
                 rs6747236 
                 35901725 
                 T 
                  975/276 
                 0.756 
                 0.777 
                 1.12 
                 0.31 
                 460/523 
                 0.771 
                 0.750 
                 0.90 
                 0.3 
               
               
                 C04 
                 rs6534683 
                 129601758 
                 T 
               
               
                 C01 
                 rs2991515 
                 57656898 
                 T 
                 1136/387 
                 0.453 
                 0.463 
                 1.04 
                 0.66 
                 427/497 
                 0.474 
                 0.466 
                 0.97 
                 0.72 
               
               
                 C04 
                 rs4697653 
                 10337857 
                 G 
                   
                   
                   
                   
                   
                 447/520 
                 0.534 
                 0.533 
                 1.00 
                 0.97 
               
               
                 C06 
                 rs9380681 
                 37638433 
                 C 
               
               
                 C10 
                 rs11199158 
                 85297471 
                 G 
               
               
                 C13 
                 rs1375719 
                 102208783 
                 C 
                  584/362 
                 0.529 
                 0.514 
                 0.94 
                 0.52 
               
               
                 C08 
                 rs3931282 
                 129179963 
                 T 
                  587/362 
                 0.532 
                 0.562 
                 1.13 
                 0.21 
               
               
                 C14 
                 rs17776453 
                 100774793 
                 G 
               
               
                 C01 
                 rs12724604 
                 20948045 
                 A 
               
               
                 C05 
                 rs950195 
                 97466690 
                 G 
               
               
                 C05 
                 rs728676 
                 118087433 
                 T 
                 1012/464 
                 0.465 
                 0.498 
                 1.14 
                 0.1 
               
               
                 C06 
                 rs7739802 
                 162154323 
                 T 
               
               
                 C10 
                 rs7086224 
                 30857283 
                 A 
               
               
                 C01 
                 rs4845552 
                 151746622 
                 G 
               
               
                 C08 
                 rs10504537 
                 73402234 
                 A 
               
               
                 C02 
                 rs1395930 
                 123468570 
                 T 
                 1216/559 
                 0.531 
                 0.484 
                 0.83 
                 0.0087 
                 489/555 
                 0.516 
                 0.529 
                 1.05 
                 0.57 
               
               
                 C02 
                 rs3943703 
                 127613790 
                 C 
               
               
                 C10 
                 rs2279434 
                 45275070 
                 T 
                  513/362 
                 0.084 
                 0.070 
                 0.83 
                 0.3 
                 472/532 
                 0.097 
                 0.081 
                 0.81 
                 0.19 
               
               
                 C10 
                 rs11198993 
                 85244450 
                 A 
               
               
                 C10 
                 rs7921473 
                 85156395 
                 G 
               
               
                 C12 
                 rs1465026 
                 65789635 
                 G 
               
               
                 C12 
                 rs1568383 
                 88017285 
                 T 
                  537/370 
                 0.127 
                 0.105 
                 0.81 
                 0.17 
                 467/528 
                 0.123 
                 0.116 
                 0.94 
                 0.65 
               
               
                 C08 
                 rs4732849 
                 28249765 
                 T 
                 1160/411 
                 0.316 
                 0.330 
                 1.06 
                 0.48 
                 486/554 
                 0.315 
                 0.312 
                 0.99 
                 0.9 
               
               
                 C08 
                 rs7006687 
                 18277862 
                 T 
               
               
                 C02 
                 rs921083 
                 176453128 
                 G 
                   
                   
                   
                   
                   
                 493/563 
                 0.813 
                 0.804 
                 0.94 
                 0.57 
               
               
                 C02 
                 rs6709904 
                 43933828 
                 A 
               
               
                 C14 
                 rs1957860 
                 53499105 
                 T 
                 1188/419 
                 0.476 
                 0.486 
                 1.04 
                 0.62 
                 492/565 
                 0.497 
                 0.471 
                 0.90 
                 0.23 
               
               
                 C14 
                 rs4444235 
                 53480669 
                 T 
                 1160/404 
                 0.534 
                 0.524 
                 0.96 
                 0.62 
                 489/551 
                 0.535 
                 0.521 
                 0.95 
                 0.53 
               
               
                   
               
            
           
           
               
               
            
               
                 Table 4B - CAD 
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Pos Build 
                   
                 Atlanta (1273/772) 
                 Philadelphia (497/700) 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Chr 
                 SNP 
                 36 
                 Allele 
                 nc/na 
                 Ctr. fr 
                 Aff. fr 
                 OR 
                 P 
                 nc/na 
                 Ctr. fr 
                 Aff. fr 
                 OR 
                 P 
               
               
                   
               
               
                 C06 
                 rs11751605 
                 160883220 
                 C 
                 1273/772 
                 0.155 
                 0.163 
                 1.07 
                 0.47 
                 497/693 
                 0.131 
                 0.139 
                 1.08 
                 0.55 
               
               
                 C20 
                 rs6076623 
                 4084671 
                 T 
                 1246/748 
                 0.303 
                 0.326 
                 1.11 
                 0.14 
                 494/689 
                 0.283 
                 0.275 
                 0.96 
                 0.65 
               
               
                 C10 
                 rs1412444 
                 90992907 
                 A 
                  581/475 
                 0.333 
                 0.348 
                 1.07 
                 0.46 
                 496/700 
                 0.326 
                 0.353 
                 1.13 
                 0.17 
               
               
                 C11 
                 rs2163612 
                 82856844 
                 G 
                  513/466 
                 0.496 
                 0.510 
                 1.06 
                 0.55 
                 465/539 
                 0.488 
                 0.512 
                 1.10 
                 0.29 
               
               
                 C07 
                 rs1029396 
                 116812056 
                 G 
                  572/471 
                 0.082 
                 0.086 
                 1.05 
                 0.75 
                 491/692 
                 0.074 
                 0.072 
                 0.97 
                 0.85 
               
               
                 C10 
                 rs2243547 
                 91000459 
                 G 
               
               
                 C07 
                 rs12534186 
                 117079572 
                 T 
               
               
                 C01 
                 rs12134779 
                 63168930 
                 T 
                 1260/706 
                 0.285 
                 0.290 
                 1.03 
                 0.73 
                 497/695 
                 0.270 
                 0.260 
                 0.95 
                 0.59 
               
               
                 C14 
                 rs7158073 
                 99211442 
                 T 
                  575/469 
                 0.408 
                 0.414 
                 1.02 
                 0.79 
                 480/673 
                 0.426 
                 0.442 
                 1.07 
                 0.44 
               
               
                 C05 
                 rs254850 
                 158599309 
                 T 
               
               
                 C12 
                 rs2417821 
                 20081535 
                 T 
               
               
                 C04 
                 rs7661204 
                 45728007 
                 T 
               
               
                 C05 
                 rs4921437 
                 158623529 
                 T 
               
               
                 C05 
                 rs832540 
                 56234959 
                 C 
               
               
                 C07 
                 rs324594 
                 136305863 
                 C 
               
               
                 C20 
                 rs1741318 
                 4105600 
                 A 
               
               
                 C17 
                 rs9902941 
                 17674485 
                 C 
                 1210/719 
                 0.352 
                 0.373 
                 1.09 
                 0.21 
                 474/557 
                 0.393 
                 0.419 
                 1.11 
                 0.24 
               
               
                 C05 
                 rs7709212 
                 158696755 
                 T 
               
               
                 C01 
                 rs2946534 
                 18647370 
                 T 
               
               
                 C05 
                 rs6556861 
                 94554256 
                 G 
               
               
                 C16 
                 rs8050136 
                 52373776 
                 A 
                   
                   
                   
                   
                   
                 488/685 
                 0.408 
                 0.420 
                 1.05 
                 0.54 
               
               
                 C16 
                 rs3751812 
                 52375961 
                 T 
                   
                   
                   
                   
                   
                 490/692 
                 0.397 
                 0.410 
                 1.05 
                 0.53 
               
               
                 C13 
                 rs4769613 
                 28036609 
                 T 
               
               
                 C10 
                 rs2243548 
                 91000293 
                 A 
               
               
                 C19 
                 rs12459084 
                 17031885 
                 T 
               
               
                 C06 
                 rs2074464 
                 29516507 
                 T 
                  576/474 
                 0.442 
                 0.465 
                 1.10 
                 0.28 
                 491/677 
                 0.486 
                 0.470 
                 0.94 
                 0.44 
               
               
                 C02 
                 rs2244871 
                 128115310 
                 C 
                  500/444 
                 0.431 
                 0.422 
                 0.96 
                 0.7 
                 456/525 
                 0.459 
                 0.451 
                 0.97 
                 0.72 
               
               
                 C05 
                 rs270654 
                 158497687 
                 G 
               
               
                 C17 
                 rs854787 
                 17975744 
                 C 
                  507/459 
                 0.399 
                 0.459 
                 1.27 
                 0.0086 
                 475/560 
                 0.433 
                 0.454 
                 1.09 
                 0.34 
               
               
                 C11 
                 rs7944761 
                 1361414 
                 T 
               
               
                 C15 
                 rs4779984 
                 30302218 
                 G 
               
               
                 C17 
                 rs6502622 
                 17775416 
                 G 
                 1227/719 
                 0.366 
                 0.403 
                 1.17 
                 0.021 
                 475/558 
                 0.409 
                 0.429 
                 1.08 
                 0.36 
               
               
                 C17 
                 rs3183702 
                 17688014 
                 T 
                  539/465 
                 0.337 
                 0.387 
                 1.24 
                 0.019 
                 469/548 
                 0.393 
                 0.422 
                 1.12 
                 0.2 
               
               
                 C05 
                 rs1433048 
                 158688423 
                 G 
               
               
                 C17 
                 rs4925119 
                 17683629 
                 A 
                 1207/770 
                 0.349 
                 0.373 
                 1.11 
                 0.13 
                 470/555 
                 0.397 
                 0.414 
                 1.08 
                 0.42 
               
               
                 C01 
                 rs2476601 
                 114179091 
                 A 
                 1188/323 
                 0.093 
                 0.121 
                 1.33 
                 0.044 
                 462/666 
                 0.093 
                 0.098 
                 1.05 
                 0.72 
               
               
                 C05 
                 rs870347 
                 6898035 
                 T 
               
               
                 C08 
                 rs334198 
                 18933089 
                 C 
                  542/472 
                 0.918 
                 0.908 
                 0.88 
                 0.42 
                 475/561 
                 0.900 
                 0.912 
                 1.15 
                 0.36 
               
               
                 C17 
                 rs854813 
                 17944570 
                 C 
                  539/467 
                 0.388 
                 0.442 
                 1.25 
                 0.013 
                 462/538 
                 0.429 
                 0.465 
                 1.16 
                 0.11 
               
               
                 C06 
                 rs7753765 
                 71732495 
                 A 
                  532/468 
                 0.172 
                 0.174 
                 1.02 
                 0.9 
                 479/551 
                 0.175 
                 0.172 
                 0.97 
                 0.82 
               
               
                 C17 
                 rs4925114 
                 17651995 
                 A 
                  521/461 
                 0.343 
                 0.379 
                 1.17 
                 0.098 
                 473/555 
                 0.403 
                 0.395 
                 0.97 
                 0.74 
               
               
                 C05 
                 rs270661 
                 158492732 
                 A 
               
               
                 C05 
                 rs953861 
                 158705160 
                 G 
               
               
                 C05 
                 rs10045431 
                 158747111 
                 A 
               
               
                 C14 
                 rs8003722 
                 68388015 
                 A 
                 1029/530 
                 0.147 
                 0.151 
                 1.03 
                 0.75 
               
               
                 C09 
                 rs2297538 
                 138684489 
                 G 
                   
                   
                   
                   
                   
                 404/555 
                 0.786 
                 0.749 
                 0.81 
                 0.057 
               
               
                 C02 
                 rs12329252 
                 212093968 
                 T 
                 1250/681 
                 0.681 
                 0.675 
                 0.97 
                 0.7 
                 492/696 
                 0.682 
                 0.685 
                 1.02 
                 0.86 
               
               
                 C01 
                 rs3748744 
                 19828833 
                 G 
               
               
                 C05 
                 rs4704400 
                 76586766 
                 T 
                   
                   
                   
                   
                   
                 416/576 
                 0.460 
                 0.462 
                 1.01 
                 0.95 
               
               
                 C08 
                 rs3102526 
                 96858538 
                 G 
               
               
                 C15 
                 rs2110209 
                 24946433 
                 A 
               
               
                 C16 
                 rs1870843 
                 81316815 
                 T 
               
               
                 C08 
                 rs3134517 
                 96859237 
                 G 
               
               
                 C21 
                 rs2828495 
                 24038081 
                 A 
               
               
                 C04 
                 rs4282162 
                 21426819 
                 T 
               
               
                 C17 
                 rs2955355 
                 17889200 
                 C 
                  534/463 
                 0.291 
                 0.351 
                 1.32 
                 0.0043 
                 476/562 
                 0.352 
                 0.359 
                 1.03 
                 0.72 
               
               
                 C12 
                 rs11045689 
                 21092930 
                 G 
                 1196/462 
                 0.345 
                 0.345 
                 1.00 
                 0.99 
                 492/680 
                 0.362 
                 0.347 
                 0.94 
                 0.46 
               
               
                 C05 
                 rs7447732 
                 158461713 
                 C 
                 1225/669 
                 0.315 
                 0.299 
                 0.93 
                 0.32 
                 497/691 
                 0.272 
                 0.310 
                 1.20 
                 0.044 
               
               
                 C18 
                 rs1365254 
                 70238283 
                 T 
               
               
                 C13 
                 rs1887263 
                 22381716 
                 A 
               
               
                 C12 
                 rs12304836 
                 124654446 
                 C 
                 1217/712 
                 0.152 
                 0.151 
                 0.99 
                 0.9 
                 472/550 
                 0.145 
                 0.170 
                 1.21 
                 0.12 
               
               
                 C05 
                 rs38055 
                 52596401 
                 T 
                 1259/680 
                 0.311 
                 0.337 
                 1.13 
                 0.096 
                 491/690 
                 0.305 
                 0.341 
                 1.17 
                 0.073 
               
               
                 C04 
                 rs4697653 
                 10337857 
                 G 
                   
                   
                   
                   
                   
                 447/619 
                 0.534 
                 0.537 
                 1.01 
                 0.87 
               
               
                 C05 
                 rs728676 
                 118087433 
                 T 
                 1012/522 
                 0.465 
                 0.496 
                 1.13 
                 0.11 
               
               
                 C06 
                 rs6905466 
                 19958854 
                 T 
               
               
                 C10 
                 rs11199158 
                 85297471 
                 G 
               
               
                 C01 
                 rs4845552 
                 151746622 
                 G 
               
               
                 C02 
                 rs1395930 
                 123468570 
                 T 
                 1216/686 
                 0.531 
                 0.483 
                 0.83 
                 0.0044 
                 489/681 
                 0.516 
                 0.524 
                 1.03 
                 0.71 
               
               
                 C04 
                 rs6534683 
                 129601758 
                 T 
               
               
                 C02 
                 rs6747236 
                 35901725 
                 T 
                  975/312 
                 0.756 
                 0.782 
                 1.16 
                 0.19 
                 460/640 
                 0.771 
                 0.761 
                 0.95 
                 0.6 
               
               
                 C06 
                 rs3016536 
                 162157939 
                 G 
               
               
                 C10 
                 rs12269612 
                 15475877 
                 T 
               
               
                 C17 
                 rs854793 
                 17971249 
                 A 
                  539/475 
                 0.213 
                 0.252 
                 1.24 
                 0.042 
                 454/522 
                 0.246 
                 0.259 
                 1.07 
                 0.51 
               
               
                 C12 
                 rs3742049 
                 119438873 
                 C 
                  584/470 
                 0.901 
                 0.904 
                 1.04 
                 0.78 
               
               
                 C01 
                 rs2991515 
                 57656898 
                 T 
                 1136/430 
                 0.453 
                 0.462 
                 1.03 
                 0.68 
                 427/621 
                 0.474 
                 0.461 
                 0.95 
                 0.56 
               
               
                 C18 
                 rs4271662 
                 26051291 
                 C 
                 1216/676 
                 0.598 
                 0.611 
                 1.06 
                 0.43 
                 487/676 
                 0.611 
                 0.620 
                 1.04 
                 0.66 
               
               
                 C06 
                 rs7739802 
                 162154323 
                 T 
               
               
                 C08 
                 rs10504537 
                 73402234 
                 A 
               
               
                 C14 
                 rs17776453 
                 100774793 
                 G 
               
               
                 C10 
                 rs7086224 
                 30857283 
                 A 
               
               
                 C01 
                 rs12724604 
                 20948045 
                 A 
               
               
                 C03 
                 rs9874646 
                 62437858 
                 T 
                 1193/457 
                 0.684 
                 0.690 
                 1.03 
                 0.72 
                 492/683 
                 0.648 
                 0.679 
                 1.15 
                 0.13 
               
               
                 C05 
                 rs950195 
                 97466690 
                 G 
               
               
                 C14 
                 rs2281519 
                 93846385 
                 T 
               
               
                 C10 
                 rs4880711 
                 5217871 
                 C 
               
               
                 C08 
                 rs3931282 
                 129179963 
                 T 
                  587/469 
                 0.532 
                 0.560 
                 1.12 
                 0.21 
               
               
                 C10 
                 rs11198993 
                 85244450 
                 A 
               
               
                 C12 
                 rs1568383 
                 88017285 
                 T 
                  537/472 
                 0.127 
                 0.105 
                 0.81 
                 0.13 
                 467/546 
                 0.123 
                 0.116 
                 0.94 
                 0.64 
               
               
                 C06 
                 rs9380681 
                 37638433 
                 C 
               
               
                 C02 
                 rs6709904 
                 43933828 
                 A 
                 959/51 
                 0.903 
                 0.912 
                 1.12 
                 0.76 
               
               
                 C10 
                 rs2279434 
                 45275070 
                 T 
                  513/462 
                 0.084 
                 0.076 
                 0.90 
                 0.51 
                 472/550 
                 0.097 
                 0.078 
                 0.79 
                 0.12 
               
               
                 C13 
                 rs1375719 
                 102208783 
                 C 
                  584/469 
                 0.529 
                 0.499 
                 0.89 
                 0.17 
               
               
                 C10 
                 rs7921473 
                 85156395 
                 G 
               
               
                 C14 
                 rs1957860 
                 53499105 
                 T 
                 1188/462 
                 0.476 
                 0.483 
                 1.03 
                 0.71 
                 492/691 
                 0.497 
                 0.475 
                 0.91 
                 0.29 
               
               
                 C02 
                 rs3943703 
                 127613790 
                 C 
               
               
                 C08 
                 rs7006687 
                 18277862 
                 T 
               
               
                 C12 
                 rs1465026 
                 65789635 
                 G 
               
               
                 C14 
                 rs4444235 
                 53480669 
                 T 
                 1160/445 
                 0.534 
                 0.527 
                 0.97 
                 0.74 
                 489/673 
                 0.535 
                 0.516 
                 0.93 
                 0.36 
               
               
                 C02 
                 rs921083 
                 176453128 
                 G 
                   
                   
                   
                   
                   
                 493/689 
                 0.813 
                 0.810 
                 0.98 
                 0.83 
               
               
                 C08 
                 rs4732849 
                 28249765 
                 T 
                 1160/454 
                 0.316 
                 0.326 
                 1.05 
                 0.6 
                 486/678 
                 0.315 
                 0.316 
                 1.00 
                 0.97 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Table 4C - MI 
                 Durham (737/1199) 
                 Italy (1076/657) 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Chr 
                 SNP 
                 Pos_B36 
                 Allele 
                 nc/na 
                 Ctr. fr 
                 Aff. fr 
                 OR 
                 P 
                 nc/na 
                 Ctr. fr 
                 Aff. fr 
                 OR 
                 P 
               
               
                   
               
               
                 C06 
                 rs11751605 
                 160883220 
                 C 
                 731/1187 
                 0.158 
                 0.174 
                 1.12 
                 0.21 
                 1075/656 
                 0.083 
                 0.100 
                 1.22 
                 0.099 
               
               
                 C10 
                 rs2243547 
                 91000459 
                 G 
               
               
                 C10 
                 rs1412444 
                 90992907 
                 A 
                 730/1190 
                 0.344 
                 0.356 
                 1.05 
                 0.45 
                 1068/646 
                 0.309 
                 0.328 
                 1.09 
                 0.25 
               
               
                 C01 
                 rs12134779 
                 63168930 
                 T 
                 731/1191 
                 0.282 
                 0.309 
                 1.14 
                 0.078 
                 1055/646 
                 0.248 
                 0.266 
                 1.10 
                 0.25 
               
               
                 C11 
                 rs2163612 
                 62856844 
                 G 
                 732/1182 
                 0.484 
                 0.491 
                 1.03 
                 0.67 
               
               
                 C05 
                 rs254850 
                 158599309 
                 T 
               
               
                 C17 
                 rs9902941 
                 17674485 
                 C 
                 736/1150 
                 0.355 
                 0.378 
                 1.10 
                 0.15 
               
               
                 C20 
                 rs6076623 
                 4084671 
                 T 
                 737/1195 
                 0.307 
                 0.323 
                 1.08 
                 0.28 
                 1062/649 
                 0.222 
                 0.213 
                 0.95 
                 0.57 
               
               
                 C05 
                 rs4921437 
                 158623529 
                 T 
                 725/1194 
                 0.197 
                 0.194 
                 0.98 
                 0.8 
                 1045/639 
                 0.171 
                 0.174 
                 1.02 
                 0.81 
               
               
                 C05 
                 rs832540 
                 56234959 
                 C 
                 711/1175 
                 0.370 
                 0.385 
                 1.06 
                 0.36 
                 1052/642 
                 0.372 
                 0.363 
                 0.96 
                 0.59 
               
               
                 C19 
                 rs12459084 
                 17031885 
                 T 
                 732/1196 
                 0.413 
                 0.409 
                 0.98 
                 0.82 
               
               
                 C07 
                 rs1029396 
                 116812056 
                 G 
                 735/1197 
                 0.083 
                 0.102 
                 1.26 
                 0.045 
                 1076/657 
                 0.062 
                 0.053 
                 0.84 
                 0.25 
               
               
                 C17 
                 rs6502622 
                 17775416 
                 G 
                 734/1150 
                 0.377 
                 0.400 
                 1.10 
                 0.17 
                 1048/639 
                 0.456 
                 0.450 
                 0.98 
                 0.75 
               
               
                 C17 
                 rs854787 
                 17975744 
                 C 
                 732/1180 
                 0.413 
                 0.438 
                 1.11 
                 0.13 
                 1017/611 
                 0.501 
                 0.489 
                 0.95 
                 0.52 
               
               
                 C14 
                 rs7158073 
                 99211442 
                 T 
                 719/1159 
                 0.429 
                 0.461 
                 1.14 
                 0.058 
                  490/270 
                 0.458 
                 0.407 
                 0.81 
                 0.056 
               
               
                 C10 
                 rs2243548 
                 91000293 
                 A 
               
               
                 C17 
                 rs4925119 
                 17683629 
                 A 
                 729/1173 
                 0.350 
                 0.374 
                 1.11 
                 0.13 
                 1026/640 
                 0.437 
                 0.430 
                 0.97 
                 0.67 
               
               
                 C17 
                 rs3183702 
                 17688014 
                 T 
                 572/926  
                 0.355 
                 0.369 
                 1.06 
                 0.44 
                 1059/641 
                 0.435 
                 0.422 
                 0.95 
                 0.46 
               
               
                 C17 
                 rs854813 
                 17944570 
                 C 
                 209/412  
                 0.392 
                 0.417 
                 1.11 
                 0.39 
                 1057/646 
                 0.502 
                 0.469 
                 0.88 
                 0.059 
               
               
                 C05 
                 rs953861 
                 158705160 
                 G 
               
               
                 C07 
                 rs12534186 
                 117079572 
                 T 
               
               
                 C12 
                 rs2417821 
                 20081535 
                 T 
                 725/1186 
                 0.720 
                 0.721 
                 1.01 
                 0.93 
                 1042/641 
                 0.668 
                 0.670 
                 1.01 
                 0.92 
               
               
                 C20 
                 rs1741318 
                 4105600 
                 A 
               
               
                 C06 
                 rs2074464 
                 29516507 
                 T 
                 728/1184 
                 0.451 
                 0.466 
                 1.06 
                 0.37 
                 1034/634 
                 0.462 
                 0.452 
                 0.96 
                 0.58 
               
               
                 C07 
                 rs324594 
                 136305863 
                 C 
               
               
                 C05 
                 rs270654 
                 158497687 
                 G 
               
               
                 C15 
                 rs4779984 
                 30302218 
                 G 
               
               
                 C05 
                 rs7709212 
                 158696755 
                 T 
               
               
                 C05 
                 rs10045431 
                 158747111 
                 A 
               
               
                 C17 
                 rs2955355 
                 17889200 
                 C 
                 212/413  
                 0.302 
                 0.337 
                 1.17 
                 0.21 
                 1052/614 
                 0.402 
                 0.374 
                 0.89 
                 0.11 
               
               
                 C11 
                 rs7944761 
                 1361414 
                 T 
               
               
                 C05 
                 rs4704400 
                 76586766 
                 T 
               
               
                 C17 
                 rs4925114 
                 17651995 
                 A 
                 211/413  
                 0.353 
                 0.389 
                 1.16 
                 0.22 
               
               
                 C05 
                 rs1433048 
                 158688423 
                 G 
               
               
                 C05 
                 rs7447732 
                 158461713 
                 C 
                 732/1198 
                 0.328 
                 0.314 
                 0.94 
                 0.37 
                 1067/643 
                 0.305 
                 0.285 
                 0.91 
                 0.23 
               
               
                 C02 
                 rs2244871 
                 128115310 
                 C 
                 563/924  
                 0.388 
                 0.439 
                 1.24 
                 0.0059 
               
               
                 C01 
                 rs2946534 
                 18647370 
                 T 
               
               
                 C04 
                 rs7661204 
                 45728007 
                 T 
                 720/1183 
                 0.411 
                 0.435 
                 1.10 
                 0.14 
               
               
                 C05 
                 rs6556861 
                 94554256 
                 G 
                 719/1169 
                 0.631 
                 0.615 
                 0.93 
                 0.33 
                 1056/637 
                 0.652 
                 0.633 
                 0.92 
                 0.27 
               
               
                 C06 
                 rs7753765 
                 71732495 
                 A 
               
               
                 C05 
                 rs870347 
                 6898035 
                 T 
               
               
                 C10 
                 rs12269612 
                 15475877 
                 T 
                 734/1196 
                 0.382 
                 0.361 
                 0.91 
                 0.19 
                 1055/634 
                 0.382 
                 0.363 
                 0.92 
                 0.26 
               
               
                 C15 
                 rs2110209 
                 24946433 
                 A 
                 737/1191 
                 0.035 
                 0.032 
                 0.93 
                 0.7 
               
               
                 C02 
                 rs12329252 
                 212093968 
                 T 
                 737/1197 
                 0.659 
                 0.665 
                 1.03 
                 0.69 
                 1047/642 
                 0.713 
                 0.694 
                 0.91 
                 0.23 
               
               
                 C14 
                 rs8003722 
                 68388015 
                 A 
                 735/1186 
                 0.144 
                 0.136 
                 0.94 
                 0.48 
               
               
                 C21 
                 rs2828495 
                 24038081 
                 A 
               
               
                 C05 
                 rs270661 
                 158492732 
                 A 
                 736/1196 
                 0.209 
                 0.189 
                 0.89 
                 0.15 
                 1066/652 
                 0.194 
                 0.173 
                 0.87 
                 0.12 
               
               
                 C08 
                 rs334198 
                 18933089 
                 C 
               
               
                 C01 
                 rs2476601 
                 114179091 
                 A 
                 572/921  
                 0.087 
                 0.097 
                 1.14 
                 0.33 
                 1049/647 
                 0.062 
                 0.070 
                 1.12 
                 0.42 
               
               
                 C13 
                 rs4769613 
                 28036609 
                 T 
                 733/1190 
                 0.458 
                 0.463 
                 1.02 
                 0.77 
                 1052/632 
                 0.498 
                 0.487 
                 0.96 
                 0.53 
               
               
                 C08 
                 rs3102526 
                 96858538 
                 G 
               
               
                 C08 
                 rs3134517 
                 96859237 
                 G 
               
               
                 C01 
                 rs3748744 
                 19828833 
                 G 
               
               
                 C04 
                 rs4282162 
                 21426819 
                 T 
                 732/1198 
                 0.488 
                 0.488 
                 1.00 
                 0.99 
               
               
                 C16 
                 rs8050136 
                 52373776 
                 A 
                   
                   
                   
                   
                   
                 1064/635 
                 0.414 
                 0.425 
                 1.05 
                 0.52 
               
               
                 C16 
                 rs3751812 
                 52375961 
                 T 
                   
                   
                   
                   
                   
                 1070/651 
                 0.412 
                 0.420 
                 1.04 
                 0.63 
               
               
                 C17 
                 rs854793 
                 17971249 
                 A 
                 213/393  
                 0.202 
                 0.224 
                 1.14 
                 0.37 
                 1031/649 
                 0.268 
                 0.240 
                 0.87 
                 0.077 
               
               
                 C10 
                 rs4880711 
                 5217871 
                 C 
               
               
                 C12 
                 rs12304836 
                 124654446 
                 C 
                 729/1172 
                 0.147 
                 0.145 
                 0.99 
                 0.91 
               
               
                 C05 
                 rs380555 
                 2596401 
                 T 
                 729/1194 
                 0.306 
                 0.311 
                 1.02 
                 0.75 
                 1054/641 
                 0.316 
                 0.306 
                 0.95 
                 0.54 
               
               
                 C09 
                 rs2297538 
                 138684489 
                 G 
                 736/1193 
                 0.798 
                 0.795 
                 0.98 
                 0.79 
                  712/231 
                 0.754 
                 0.755 
                 1.01 
                 0.96 
               
               
                 C16 
                 rs18708438 
                 1316815 
                 T 
               
               
                 C06 
                 rs6905466 
                 19958854 
                 T 
               
               
                 C12 
                 rs11045689 
                 21092930 
                 G 
                 734/1195 
                 0.328 
                 0.365 
                 1.18 
                 0.019 
               
               
                 C13 
                 rs1887263 
                 22381716 
                 A 
               
               
                 C18 
                 rs4271662 
                 26051291 
                 C 
                 736/1194 
                 0.596 
                 0.601 
                 1.02 
                 0.76 
                 1045/621 
                 0.644 
                 0.634 
                 0.96 
                 0.55 
               
               
                 C18 
                 rs1365254 
                 70238283 
                 T 
               
               
                 C06 
                 rs3016536 
                 162157939 
                 G 
               
               
                 C12 
                 rs3742049 
                 119438873 
                 C 
                 120/254  
                 0.896 
                 0.884 
                 0.88 
                 0.63 
               
               
                 C03 
                 rs9874646 
                 62437858 
                 T 
                 735/1199 
                 0.686 
                 0.681 
                 0.98 
                 0.74 
               
               
                 C14 
                 rs2281519 
                 93846385 
                 T 
               
               
                 C02 
                 rs6747236 
                 35901725 
                 T 
                 432/1102 
                 0.760 
                 0.774 
                 1.08 
                 0.44 
               
               
                 C04 
                 rs6534683 
                 129601758 
                 T 
               
               
                 C01 
                 rs2991515 
                 57656898 
                 T 
               
               
                 C04 
                 rs4697653 
                 10337857 
                 G 
                 723/1187 
                 0.558 
                 0.540 
                 0.93 
                 0.27 
                 1019/624 
                 0.546 
                 0.559 
                 1.06 
                 0.44 
               
               
                 C06 
                 rs9380681 
                 37638433 
                 C 
               
               
                 C10 
                 rs11199158 
                 85297471 
                 G 
                 734/1195 
                 0.636 
                 0.638 
                 1.01 
                 0.89 
                 1049/641 
                 0.653 
                 0.651 
                 0.99 
                 0.91 
               
               
                 C13 
                 rs1375719 
                 102208783 
                 C 
                 116/250  
                 0.504 
                 0.464 
                 0.85 
                 0.31 
               
               
                 C08 
                 rs3931282 
                 129179963 
                 T 
                 732/1182 
                 0.524 
                 0.542 
                 1.08 
                 0.27 
               
               
                 C14 
                 rs17776453 
                 100774793 
                 G 
               
               
                 C01 
                 rs12724604 
                 20948045 
                 A 
               
               
                 C05 
                 rs950195 
                 97466690 
                 G 
                 727/1193 
                 0.646 
                 0.633 
                 0.94 
                 0.39 
                 1036/637 
                 0.647 
                 0.617 
                 0.88 
                 0.083 
               
               
                 C05 
                 rs728676 
                 118087433 
                 T 
                 718/1152 
                 0.493 
                 0.486 
                 0.97 
                 0.66 
               
               
                 C06 
                 rs7739802 
                 162154323 
                 T 
               
               
                 C10 
                 rs7086224 
                 30857283 
                 A 
               
               
                 C01 
                 rs4845552 
                 151746622 
                 G 
                 736/1197 
                 0.140 
                 0.154 
                 1.12 
                 0.24 
                 1060/647 
                 0.153 
                 0.123 
                 0.78 
                 0.014 
               
               
                 C08 
                 rs10504537 
                 73402234 
                 A 
               
               
                 C02 
                 rs1395930 
                 123468570 
                 T 
                 737/1188 
                 0.507 
                 0.508 
                 1.00 
                 0.97 
                 1037/638 
                 0.548 
                 0.571 
                 1.10 
                 0.18 
               
               
                 C02 
                 rs3943703 
                 127613790 
                 C 
               
               
                 C10 
                 rs2279434 
                 45275070 
                 T 
               
               
                 C10 
                 rs11198993 
                 85244450 
                 A 
                 732/1192 
                 0.774 
                 0.759 
                 0.92 
                 0.3 
                 1048/641 
                 0.776 
                 0.786 
                 1.06 
                 0.49 
               
               
                 C10 
                 rs7921473 
                 85156395 
                 G 
                 733/1177 
                 0.840 
                 0.828 
                 0.91 
                 0.3 
                 1064/644 
                 0.823 
                 0.816 
                 0.95 
                 0.61 
               
               
                 C12 
                 rs1465026 
                 65789635 
                 G 
                 731/1189 
                 0.837 
                 0.821 
                 0.90 
                 0.21 
                 1061/654 
                 0.842 
                 0.847 
                 1.04 
                 0.67 
               
               
                 C12 
                 rs1568383 
                 88017285 
                 T 
               
               
                 C08 
                 rs4732849 
                 28249765 
                 T 
                 724/1188 
                 0.330 
                 0.314 
                 0.93 
                 0.3 
               
               
                 C08 
                 rs7006687 
                 18277862 
                 T 
                 730/1196 
                 0.567 
                 0.549 
                 0.93 
                 0.27 
                 1056/641 
                 0.561 
                 0.512 
                 0.82 
                 0.0059 
               
               
                 C02 
                 rs921083 
                 176453128 
                 G 
                 734/1199 
                 0.809 
                 0.817 
                 1.06 
                 0.5 
                 1057/636 
                 0.828 
                 0.831 
                 1.02 
                 0.81 
               
               
                 C02 
                 rs6709904 
                 43933828 
                 A 
                 682/1110 
                 0.891 
                 0.885 
                 0.94 
                 0.58 
               
               
                 C14 
                 rs1957860 
                 53499105 
                 T 
                 737/1198 
                 0.455 
                 0.483 
                 1.12 
                 0.082 
               
               
                 C14 
                 rs4444235 
                 53480669 
                 T 
                 733/1186 
                 0.548 
                 0.527 
                 0.92 
                 0.22 
               
               
                   
               
            
           
           
               
               
            
               
                 Table 4D - CAD 
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Pos Build 
                   
                 Durham (737/1199) 
                 Italy (1076/1122) 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Chr 
                 SNP 
                 36 
                 Allele 
                 nc/na 
                 Ctr. fr 
                 Aff. fr 
                 OR 
                 P 
                 nc/na 
                 Ctr. fr 
                 Aff. fr 
                 OR 
                 P 
               
               
                   
               
               
                 C06 
                 rs11751605 
                 160883220 
                 C 
                 731/1187 
                 0.158 
                 0.174 
                 1.12 
                 0.21 
                 1075/1122 
                 0.083 
                 0.099 
                 1.21 
                 0.071 
               
               
                 C20 
                 rs6076623 
                 4084671 
                 T 
                 737/1195 
                 0.307 
                 0.323 
                 1.08 
                 0.28 
                 1062/1105 
                 0.222 
                 0.222 
                 1.00 
                 1 
               
               
                 C10 
                 rs1412444 
                 90992907 
                 A 
                 730/1190 
                 0.344 
                 0.356 
                 1.05 
                 0.45 
                 1068/1105 
                 0.309 
                 0.330 
                 1.10 
                 0.15 
               
               
                 C11 
                 rs2163612 
                 82856844 
                 G 
                 732/1182 
                 0.484 
                 0.491 
                 1.03 
                 0.67 
               
               
                 C07 
                 rs1029396 
                 116812056 
                 G 
                 735/1197 
                 0.083 
                 0.102 
                 1.26 
                 0.045 
                 1076/1121 
                 0.062 
                 0.052 
                 0.83 
                 0.15 
               
               
                 C10 
                 rs2243547 
                 91000459 
                 G 
               
               
                 C07 
                 rs12534186 
                 117079572 
                 T 
               
               
                 C01 
                 rs12134779 
                 63168930 
                 T 
                 731/1191 
                 0.282 
                 0.309 
                 1.14 
                 0.078 
                 1055/1106 
                 0.248 
                 0.270 
                 1.12 
                 0.099 
               
               
                 C14 
                 rs7158073 
                 99211442 
                 T 
                 719/1159 
                 0.429 
                 0.461 
                 1.14 
                 0.058 
                 490/449 
                 0.458 
                 0.450 
                 0.97 
                 0.72 
               
               
                 C05 
                 rs254850 
                 158599309 
                 T 
               
               
                 C12 
                 rs2417821 
                 20081535 
                 T 
                 725/1186 
                 0.720 
                 0.721 
                 1.01 
                 0.93 
                 1042/1100 
                 0.668 
                 0.670 
                 1.01 
                 0.91 
               
               
                 C04 
                 rs7661204 
                 45728007 
                 T 
                 720/1183 
                 0.411 
                 0.435 
                 1.10 
                 0.14 
               
               
                 C05 
                 rs4921437 
                 158623529 
                 T 
                 725/1194 
                 0.197 
                 0.194 
                 0.98 
                 0.8 
                 1045/1092 
                 0.171 
                 0.178 
                 1.05 
                 0.56 
               
               
                 C05 
                 rs832540 
                 56234959 
                 C 
                 711/1175 
                 0.370 
                 0.385 
                 1.06 
                 0.36 
                 1052/1102 
                 0.372 
                 0.365 
                 0.97 
                 0.64 
               
               
                 C07 
                 rs324594 
                 136305863 
                 C 
               
               
                 C20 
                 rs1741318 
                 4105600 
                 A 
               
               
                 C17 
                 rs9902941 
                 17674485 
                 C 
                 736/1150 
                 0.355 
                 0.378 
                 1.10 
                 0.15 
               
               
                 C05 
                 rs7709212 
                 158696755 
                 T 
               
               
                 C01 
                 rs2946534 
                 18647370 
                 T 
               
               
                 C05 
                 rs6556861 
                 94554256 
                 G 
                 719/1169 
                 0.631 
                 0.615 
                 0.93 
                 0.33 
                 1056/1099 
                 0.652 
                 0.658 
                 1.03 
                 0.66 
               
               
                 C16 
                 rs8050136 
                 52373776 
                 A 
                   
                   
                   
                   
                   
                 1064/1091 
                 0.414 
                 0.425 
                 1.05 
                 0.47 
               
               
                 C16 
                 rs3751812 
                 52375961 
                 T 
                   
                   
                   
                   
                   
                 1070/1114 
                 0.412 
                 0.420 
                 1.03 
                 0.59 
               
               
                 C13 
                 rs4769613 
                 28036609 
                 T 
                 733/1190 
                 0.458 
                 0.463 
                 1.02 
                 0.77 
                 1052/1090 
                 0.498 
                 0.488 
                 0.96 
                 0.51 
               
               
                 C10 
                 rs2243548 
                 91000293 
                 A 
               
               
                 C19 
                 rs12459084 
                 17031885 
                 T 
                 732/1196 
                 0.413 
                 0.409 
                 0.98 
                 0.82 
               
               
                 C06 
                 rs2074464 
                 29516507 
                 T 
                 728/1184 
                 0.451 
                 0.466 
                 1.06 
                 0.37 
                 1034/1082 
                 0.462 
                 0.448 
                 0.94 
                 0.36 
               
               
                 C02 
                 rs2244871 
                 128115310 
                 C 
                 563/924  
                 0.388 
                 0.439 
                 1.24 
                 0.0059 
               
               
                 C05 
                 rs270654 
                 158497687 
                 G 
               
               
                 C17 
                 rs854787 
                 17975744 
                 C 
                 732/1180 
                 0.413 
                 0.438 
                 1.11 
                 0.13 
                 1017/1043 
                 0.501 
                 0.490 
                 0.96 
                 0.48 
               
               
                 C11 
                 rs7944761 
                 1361414 
                 T 
               
               
                 C15 
                 rs4779984 
                 30302218 
                 G 
               
               
                 C17 
                 rs6502622 
                 17775416 
                 G 
                 734/1150 
                 0.377 
                 0.400 
                 1.10 
                 0.17 
                 1048/1098 
                 0.456 
                 0.443 
                 0.95 
                 0.41 
               
               
                 C17 
                 rs3183702 
                 17688014 
                 T 
                 572/926  
                 0.355 
                 0.369 
                 1.06 
                 0.44 
                 1059/1099 
                 0.435 
                 0.421 
                 0.95 
                 0.37 
               
               
                 C05 
                 rs1433048 
                 158688423 
                 G 
               
               
                 C17 
                 rs4925119 
                 17683629 
                 A 
                 729/1173 
                 0.350 
                 0.374 
                 1.11 
                 0.13 
                 1026/1082 
                 0.437 
                 0.423 
                 0.95 
                 0.36 
               
               
                 C01 
                 rs2476601 
                 114179091 
                 A 
                 572/921  
                 0.087 
                 0.097 
                 1.14 
                 0.33 
                 1049/1107 
                 0.062 
                 0.067 
                 1.08 
                 0.52 
               
               
                 C05 
                 rs870347 
                 6898035 
                 T 
               
               
                 C08 
                 rs334198 
                 18933089 
                 C 
               
               
                 C17 
                 rs854813 
                 17944570 
                 C 
                 209/412  
                 0.392 
                 0.417 
                 1.11 
                 0.39 
                 1057/1102 
                 0.502 
                 0.471 
                 0.88 
                 0.036 
               
               
                 C06 
                 rs7753765 
                 71732495 
                 A 
               
               
                 C17 
                 rs4925114 
                 17651995 
                 A 
                 211/413  
                 0.353 
                 0.389 
                 1.16 
                 0.22 
               
               
                 C05 
                 rs270661 
                 158492732 
                 A 
                 736/1196 
                 0.209 
                 0.189 
                 0.89 
                 0.15 
                 1066/1112 
                 0.194 
                 0.188 
                 0.96 
                 0.63 
               
               
                 C05 
                 rs953861 
                 158705160 
                 G 
               
               
                 C05 
                 rs10045431 
                 158747111 
                 A 
               
               
                 C14 
                 rs8003722 
                 68388015 
                 A 
                 735/1186 
                 0.144 
                 0.136 
                 0.94 
                 0.48 
               
               
                 C09 
                 rs2297538 
                 138684489 
                 G 
                 736/1193 
                 0.798 
                 0.795 
                 0.98 
                 0.79 
                 712/386 
                 0.754 
                 0.750 
                 0.98 
                 0.83 
               
               
                 C02 
                 rs12329252 
                 212093968 
                 T 
                 737/1197 
                 0.659 
                 0.665 
                 1.03 
                 0.69 
                 1047/1095 
                 0.713 
                 0.688 
                 0.88 
                 0.065 
               
               
                 C01 
                 rs3748744 
                 19828833 
                 G 
               
               
                 C05 
                 rs4704400 
                 76586766 
                 T 
               
               
                 C08 
                 rs3102526 
                 96858538 
                 G 
               
               
                 C15 
                 rs2110209 
                 24946433 
                 A 
                 737/1191 
                 0.035 
                 0.032 
                 0.93 
                 0.7 
               
               
                 C16 
                 rs1870843 
                 81316815 
                 T 
               
               
                 C08 
                 rs3134517 
                 96859237 
                 G 
               
               
                 C21 
                 rs2828495 
                 24038081 
                 A 
               
               
                 C04 
                 rs4282162 
                 21426819 
                 T 
                 732/1198 
                 0.488 
                 0.488 
                 1.00 
                 0.99 
               
               
                 C17 
                 rs2955355 
                 17889200 
                 C 
                 212/413  
                 0.302 
                 0.337 
                 1.17 
                 0.21 
                 1052/1055 
                 0.402 
                 0.369 
                 0.87 
                 0.028 
               
               
                 C12 
                 rs11045689 
                 21092930 
                 G 
                 734/1195 
                 0.328 
                 0.365 
                 1.18 
                 0.019 
               
               
                 C05 
                 rs7447732 
                 158461713 
                 C 
                 732/1198 
                 0.328 
                 0.314 
                 0.94 
                 0.37 
                 1067/1100 
                 0.305 
                 0.282 
                 0.90 
                 0.11 
               
               
                 C18 
                 rs1365254 
                 70238283 
                 T 
               
               
                 C13 
                 rs1887263 
                 22381716 
                 A 
               
               
                 C12 
                 rs12304836 
                 124654446 
                 C 
                 729/1172 
                 0.147 
                 0.145 
                 0.99 
                 0.91 
               
               
                 C05 
                 rs38055 
                 52596401 
                 T 
                 729/1194 
                 0.306 
                 0.311 
                 1.02 
                 0.75 
                 1054/1102 
                 0.316 
                 0.305 
                 0.95 
                 0.45 
               
               
                 C04 
                 rs4697653 
                 10337857 
                 G 
                 723/1187 
                 0.558 
                 0.540 
                 0.93 
                 0.27 
                 1019/1076 
                 0.546 
                 0.571 
                 1.11 
                 0.097 
               
               
                 C05 
                 rs728676 
                 118087433 
                 T 
                 718/1152 
                 0.493 
                 0.486 
                 0.97 
                 0.66 
               
               
                 C06 
                 rs6905466 
                 19958854 
                 T 
               
               
                 C10 
                 rs11199158 
                 85297471 
                 G 
                 734/1195 
                 0.636 
                 0.638 
                 1.01 
                 0.89 
                 1049/1093 
                 0.653 
                 0.655 
                 1.01 
                 0.86 
               
               
                 C01 
                 rs4845552 
                 151746622 
                 G 
                 736/1197 
                 0.140 
                 0.154 
                 1.12 
                 0.24 
                 1060/1105 
                 0.153 
                 0.134 
                 0.86 
                 0.076 
               
               
                 C02 
                 rs1395930 
                 123468570 
                 T 
                 737/1188 
                 0.507 
                 0.508 
                 1.00 
                 0.97 
                 1037/1085 
                 0.548 
                 0.565 
                 1.07 
                 0.26 
               
               
                 C04 
                 rs6534683 
                 129601758 
                 T 
               
               
                 C02 
                 rs6747236 
                 35901725 
                 T 
                 432/1102 
                 0.760 
                 0.774 
                 1.08 
                 0.44 
               
               
                 C06 
                 rs3016536 
                 162157939 
                 G 
               
               
                 C10 
                 rs12269612 
                 15475877 
                 T 
                 734/1196 
                 0.382 
                 0.361 
                 0.91 
                 0.19 
                 1055/1088 
                 0.382 
                 0.353 
                 0.88 
                 0.049 
               
               
                 C17 
                 rs854793 
                 17971249 
                 A 
                 213/393  
                 0.202 
                 0.224 
                 1.14 
                 0.37 
                 1031/1102 
                 0.268 
                 0.245 
                 0.89 
                 0.083 
               
               
                 C12 
                 rs3742049 
                 119438873 
                 C 
                 120/254  
                 0.896 
                 0.884 
                 0.88 
                 0.63 
               
               
                 C01 
                 rs2991515 
                 57656898 
                 T 
               
               
                 C18 
                 rs4271662 
                 26051291 
                 C 
                 736/1194 
                 0.596 
                 0.601 
                 1.02 
                 0.76 
                 1045/1075 
                 0.644 
                 0.633 
                 0.95 
                 0.44 
               
               
                 C06 
                 rs7739802 
                 162154323 
                 T 
               
               
                 C08 
                 rs10504537 
                 73402234 
                 A 
               
               
                 C14 
                 rs17776453 
                 100774793 
                 G 
               
               
                 C10 
                 rs7086224 
                 30857283 
                 A 
               
               
                 C01 
                 rs12724604 
                 20948045 
                 A 
               
               
                 C03 
                 rs9874646 
                 62437858 
                 T 
                 735/1199 
                 0.686 
                 0.681 
                 0.98 
                 0.74 
               
               
                 C05 
                 rs950195 
                 97466690 
                 G 
                 727/1193 
                 0.646 
                 0.633 
                 0.94 
                 0.39 
                 1036/1086 
                 0.647 
                 0.622 
                 0.90 
                 0.095 
               
               
                 C14 
                 rs2281519 
                 93846385 
                 T 
               
               
                 C10 
                 rs4880711 
                 5217871 
                 C 
               
               
                 C08 
                 rs3931282 
                 129179963 
                 T 
                 732/1182 
                 0.524 
                 0.542 
                 1.08 
                 0.27 
               
               
                 C10 
                 rs11198993 
                 85244450 
                 A 
                 732/1192 
                 0.774 
                 0.759 
                 0.92 
                 0.3 
                 1048/1096 
                 0.776 
                 0.778 
                 1.01 
                 0.87 
               
               
                 C12 
                 rs1568383 
                 88017285 
                 T 
               
               
                 C06 
                 rs9380681 
                 37638433 
                 C 
               
               
                 C02 
                 rs6709904 
                 43933828 
                 A 
                 682/1110 
                 0.891 
                 0.885 
                 0.94 
                 0.58 
               
               
                 C10 
                 rs2279434 
                 45275070 
                 T 
               
               
                 C13 
                 rs1375719 
                 102208783 
                 C 
                 116/250  
                 0.504 
                 0.464 
                 0.85 
                 0.31 
               
               
                 C10 
                 rs7921473 
                 85156395 
                 G 
                 733/1177 
                 0.840 
                 0.828 
                 0.91 
                 0.3 
                 1064/1104 
                 0.823 
                 0.819 
                 0.97 
                 0.73 
               
               
                 C14 
                 rs1957860 
                 53499105 
                 T 
                 737/1198 
                 0.455 
                 0.483 
                 1.12 
                 0.082 
               
               
                 C02 
                 rs3943703 
                 127613790 
                 C 
               
               
                 C08 
                 rs7006687 
                 18277862 
                 T 
                 730/1196 
                 0.567 
                 0.549 
                 0.93 
                 0.27 
                 1056/1094 
                 0.561 
                 0.521 
                 0.85 
                 0.0077 
               
               
                 C12 
                 rs1465026 
                 65789635 
                 G 
                 731/1189 
                 0.837 
                 0.821 
                 0.90 
                 0.21 
                 1061/1118 
                 0.842 
                 0.842 
                 1.00 
                 0.97 
               
               
                 C14 
                 rs4444235 
                 53480669 
                 T 
                 733/1186 
                 0.548 
                 0.527 
                 0.92 
                 0.22 
               
               
                 C02 
                 rs921083 
                 176453128 
                 G 
                 734/1199 
                 0.809 
                 0.817 
                 1.06 
                 0.5 
                 1057/1096 
                 0.828 
                 0.828 
                 1.00 
                 0.99 
               
               
                 C08 
                 rs4732849 
                 28249765 
                 T 
                 724/1188 
                 0.330 
                 0.314 
                 0.93 
                 0.3 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Table 4E - MI 
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Pos in 
                   
                 Hopkins (1567/184) 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                   
                 Chr 
                 SNP 
                 Build 36 
                 Allele 
                 nc/na 
                 Ctr. fr 
                 Aff. fr 
                 OR 
                 P 
               
               
                   
                   
               
               
                   
                 C06 
                 rs11751605 
                 160883220 
                 C 
                 1565/184 
                 0.155 
                 0.179 
                 1.19 
                 0.23 
               
               
                   
                 C10 
                 rs2243547 
                 91000459 
                 G 
                 1539/184 
                 0.284 
                 0.323 
                 1.21 
                 0.12 
               
               
                   
                 C10 
                 rs1412444 
                 90992907 
                 A 
                 1565/183 
                 0.321 
                 0.344 
                 1.11 
                 0.38 
               
               
                   
                 C01 
                 rs12134779 
                 63168930 
                 T 
                 1567/183 
                 0.265 
                 0.281 
                 1.08 
                 0.52 
               
               
                   
                 C11 
                 rs2163612 
                 82856844 
                 G 
                 1566/182 
                 0.497 
                 0.489 
                 0.97 
                 0.78 
               
               
                   
                 C05 
                 rs254850 
                 158599309 
                 T 
                 1567/184 
                 0.195 
                 0.190 
                 0.97 
                 0.83 
               
               
                   
                 C17 
                 rs9902941 
                 17674485 
                 C 
                 1567/183 
                 0.367 
                 0.350 
                 0.93 
                 0.51 
               
               
                   
                 C20 
                 rs6076623 
                 4084671 
                 T 
                 1567/183 
                 0.296 
                 0.325 
                 1.15 
                 0.25 
               
               
                   
                 C05 
                 rs4921437 
                 158623529 
                 T 
                 1566/183 
                 0.184 
                 0.189 
                 1.03 
                 0.84 
               
               
                   
                 C05 
                 rs832540 
                 56234959 
                 C 
                 1567/184 
                 0.361 
                 0.397 
                 1.16 
                 0.18 
               
               
                   
                 C19 
                 rs12459084 
                 17031885 
                 T 
                 1512/182 
                 0.415 
                 0.434 
                 1.08 
                 0.48 
               
               
                   
                 C07 
                 rs1029396 
                 116812056 
                 G 
                 1566/183 
                 0.080 
                 0.115 
                 1.50 
                 0.027 
               
               
                   
                 C17 
                 rs6502622 
                 17775416 
                 G 
                 1563/184 
                 0.401 
                 0.386 
                 0.94 
                 0.59 
               
               
                   
                 C17 
                 rs854787 
                 17975744 
                 C 
                 1552/181 
                 0.428 
                 0.406 
                 0.92 
                 0.43 
               
               
                   
                 C14 
                 rs7158073 
                 99211442 
                 T 
                 1509/180 
                 0.431 
                 0.428 
                 0.99 
                 0.9 
               
               
                   
                 C10 
                 rs2243548 
                 91000293 
                 A 
                 1566/183 
                 0.504 
                 0.544 
                 1.17 
                 0.15 
               
               
                   
                 C17 
                 rs4925119 
                 17683629 
                 A 
                 1542/181 
                 0.361 
                 0.340 
                 0.91 
                 0.43 
               
               
                   
                 C17 
                 rs3183702 
                 17688014 
                 T 
                 1561/183 
                 0.365 
                 0.344 
                 0.92 
                 0.44 
               
               
                   
                 C17 
                 rs854813 
                 17944570 
                 C 
                 1551/180 
                 0.409 
                 0.381 
                 0.89 
                 0.3 
               
               
                   
                 C05 
                 rs953861 
                 158705160 
                 G 
                 1565/184 
                 0.168 
                 0.168 
                 1.00 
                 1 
               
               
                   
                 C07 
                 rs12534186 
                 117079572 
                 T 
                 1567/184 
                 0.095 
                 0.125 
                 1.36 
                 0.077 
               
               
                   
                 C12 
                 rs2417821 
                 20081535 
                 T 
                 1566/184 
                 0.728 
                 0.723 
                 0.97 
                 0.82 
               
               
                   
                 C20 
                 rs1741318 
                 4105600 
                 A 
                 1566/183 
                 0.377 
                 0.383 
                 1.02 
                 0.83 
               
               
                   
                 C06 
                 rs2074464 
                 29516507 
                 T 
                 1562/183 
                 0.447 
                 0.426 
                 0.92 
                 0.46 
               
               
                   
                 C07 
                 rs324594 
                 136305863 
                 C 
                 1567/183 
                 0.269 
                 0.240 
                 0.86 
                 0.23 
               
               
                   
                 C05 
                 rs270654 
                 158497687 
                 G 
                 1567/183 
                 0.108 
                 0.096 
                 0.88 
                 0.48 
               
               
                   
                 C15 
                 rs4779984 
                 30302218 
                 G 
                 1562/183 
                 0.125 
                 0.134 
                 1.08 
                 0.64 
               
               
                   
                 C05 
                 rs7709212 
                 158696755 
                 T 
                 1567/183 
                 0.674 
                 0.699 
                 1.12 
                 0.33 
               
               
                   
                 C05 
                 rs10045431 
                 158747111 
                 A 
                 1567/184 
                 0.289 
                 0.299 
                 1.05 
                 0.7 
               
               
                   
                 C17 
                 rs2955355 
                 17889200 
                 C 
                 1565/183 
                 0.318 
                 0.306 
                 0.95 
                 0.65 
               
               
                   
                 C11 
                 rs7944761 
                 1361414 
                 T 
                 1567/184 
                 0.563 
                 0.571 
                 1.03 
                 0.79 
               
               
                   
                 C05 
                 rs4704400 
                 76586766 
                 T 
                 1563/183 
                 0.485 
                 0.503 
                 1.07 
                 0.52 
               
               
                   
                 C17 
                 rs4925114 
                 17651995 
                 A 
                 1561/183 
                 0.372 
                 0.344 
                 0.89 
                 0.3 
               
               
                   
                 C05 
                 rs1433048 
                 158688423 
                 G 
                 1565/183 
                 0.184 
                 0.172 
                 0.92 
                 0.56 
               
               
                   
                 C05 
                 rs7447732 
                 158461713 
                 C 
                 1566/184 
                 0.321 
                 0.323 
                 1.01 
                 0.92 
               
               
                   
                 C02 
                 rs2244871 
                 128115310 
                 C 
                 1556/182 
                 0.426 
                 0.396 
                 0.88 
                 0.26 
               
               
                   
                 C01 
                 rs2946534 
                 18647370 
                 T 
                 1564/183 
                 0.548 
                 0.552 
                 1.02 
                 0.88 
               
               
                   
                 C04 
                 rs7661204 
                 45728007 
                 T 
                 1567/183 
                 0.410 
                 0.385 
                 0.90 
                 0.36 
               
               
                   
                 C05 
                 rs6556861 
                 94554256 
                 G 
                 1567/183 
                 0.623 
                 0.612 
                 0.95 
                 0.68 
               
               
                   
                 C06 
                 rs7753765 
                 71732495 
                 A 
                 1567/184 
                 0.170 
                 0.188 
                 1.13 
                 0.4 
               
               
                   
                 C05 
                 rs870347 
                 6898035 
                 T 
                 1566/184 
                 0.940 
                 0.946 
                 1.11 
                 0.66 
               
               
                   
                 C10 
                 rs12269612 
                 15475877 
                 T 
                 1567/184 
                 0.376 
                 0.399 
                 1.10 
                 0.38 
               
               
                   
                 C15 
                 rs2110209 
                 24946433 
                 A 
                 1567/184 
                 0.031 
                 0.024 
                 0.78 
                 0.46 
               
               
                   
                 C02 
                 rs12329252 
                 212093968 
                 T 
                 1567/183 
                 0.657 
                 0.678 
                 1.10 
                 0.44 
               
               
                   
                 C14 
                 rs8003722 
                 68388015 
                 A 
                 1566/183 
                 0.138 
                 0.139 
                 1.01 
                 0.93 
               
               
                   
                 C21 
                 rs2828495 
                 24038081 
                 A 
                 1566/183 
                 0.233 
                 0.230 
                 0.98 
                 0.89 
               
               
                   
                 C05 
                 rs270661 
                 158492732 
                 A 
                 1567/184 
                 0.194 
                 0.171 
                 0.86 
                 0.29 
               
               
                   
                 C08 
                 rs334198 
                 18933089 
                 C 
                 1566/184 
                 0.922 
                 0.924 
                 1.02 
                 0.92 
               
               
                   
                 C01 
                 rs2476601 
                 114179091 
                 A 
                 1566/183 
                 0.091 
                 0.096 
                 1.06 
                 0.77 
               
               
                   
                 C13 
                 rs4769613 
                 28036609 
                 T 
                 1567/183 
                 0.469 
                 0.514 
                 1.20 
                 0.11 
               
               
                   
                 C08 
                 rs3102526 
                 96858538 
                 G 
                 1565/183 
                 0.620 
                 0.658 
                 1.18 
                 0.15 
               
               
                   
                 C08 
                 rs3134517 
                 96859237 
                 G 
                 1567/184 
                 0.620 
                 0.658 
                 1.18 
                 0.15 
               
               
                   
                 C01 
                 rs3748744 
                 19828833 
                 G 
                 1561/182 
                 0.896 
                 0.912 
                 1.21 
                 0.32 
               
               
                   
                 C04 
                 rs4282162 
                 21426819 
                 T 
                 1567/183 
                 0.503 
                 0.525 
                 1.09 
                 0.42 
               
               
                   
                 C16 
                 rs8050136 
                 52373776 
                 A 
                 1567/183 
                 0.411 
                 0.402 
                 0.96 
                 0.72 
               
               
                   
                 C16 
                 rs3751812 
                 52375961 
                 T 
                 1567/184 
                 0.410 
                 0.402 
                 0.97 
                 0.78 
               
               
                   
                 C17 
                 rs854793 
                 17971249 
                 A 
                 1567/183 
                 0.232 
                 0.235 
                 1.02 
                 0.89 
               
               
                   
                 C10 
                 rs4880711 
                 5217871 
                 C 
                 1562/184 
                 0.349 
                 0.394 
                 1.22 
                 0.087 
               
               
                   
                 C12 
                 rs12304836 
                 124654446 
                 C 
                 1567/184 
                 0.151 
                 0.155 
                 1.03 
                 0.84 
               
               
                   
                 C05 
                 rs38055 
                 52596401 
                 T 
                 1567/184 
                 0.340 
                 0.315 
                 0.89 
                 0.34 
               
               
                   
                 C09 
                 rs2297538 
                 138684489 
                 G 
                 1555/180 
                 0.791 
                 0.789 
                 0.99 
                 0.91 
               
               
                   
                 C16 
                 rs1870843 
                 81316815 
                 T 
                 1567/184 
                 0.603 
                 0.587 
                 0.94 
                 0.55 
               
               
                   
                 C06 
                 rs6905466 
                 19958854 
                 T 
                 1567/183 
                 0.338 
                 0.342 
                 1.02 
                 0.89 
               
               
                   
                 C12 
                 rs11045689 
                 21092930 
                 G 
                 1557/182 
                 0.346 
                 0.288 
                 0.76 
                 0.025 
               
               
                   
                 C13 
                 rs1887263 
                 22381716 
                 A 
                 1567/184 
                 0.174 
                 0.193 
                 1.13 
                 0.38 
               
               
                   
                 C18 
                 rs4271662 
                 26051291 
                 C 
                 1567/183 
                 0.595 
                 0.617 
                 1.10 
                 0.41 
               
               
                   
                 C18 
                 rs1365254 
                 70238283 
                 T 
                 1567/184 
                 0.187 
                 0.168 
                 0.88 
                 0.39 
               
               
                   
                 C06 
                 rs3016536 
                 162157939 
                 G 
                 1567/183 
                 0.596 
                 0.579 
                 0.93 
                 0.54 
               
               
                   
                 C12 
                 rs3742049 
                 119438873 
                 C 
                 1565/183 
                 0.885 
                 0.888 
                 1.03 
                 0.86 
               
               
                   
                 C03 
                 rs9874646 
                 62437858 
                 T 
                 1567/183 
                 0.669 
                 0.699 
                 1.15 
                 0.24 
               
               
                   
                 C14 
                 rs2281519 
                 93846385 
                 T 
                 1564/183 
                 0.267 
                 0.235 
                 0.84 
                 0.18 
               
               
                   
                 C02 
                 rs6747236 
                 35901725 
                 T 
                 1566/184 
                 0.755 
                 0.726 
                 0.86 
                 0.21 
               
               
                   
                 C04 
                 rs6534683 
                 129601758 
                 T 
                 1567/183 
                 0.652 
                 0.628 
                 0.90 
                 0.37 
               
               
                   
                 C01 
                 rs2991515 
                 57656898 
                 T 
                 1565/184 
                 0.458 
                 0.438 
                 0.92 
                 0.44 
               
               
                   
                 C04 
                 rs4697653 
                 10337857 
                 G 
                 1553/182 
                 0.567 
                 0.569 
                 1.01 
                 0.95 
               
               
                   
                 C06 
                 rs9380681 
                 37638433 
                 C 
                 1567/183 
                 0.315 
                 0.328 
                 1.06 
                 0.62 
               
               
                   
                 C10 
                 rs11199158 
                 85297471 
                 G 
                 1566/183 
                 0.645 
                 0.623 
                 0.91 
                 0.41 
               
               
                   
                 C13 
                 rs1375719 
                 102208783 
                 C 
                 1566/183 
                 0.492 
                 0.516 
                 1.10 
                 0.37 
               
               
                   
                 C08 
                 rs3931282 
                 129179963 
                 T 
                 1567/184 
                 0.517 
                 0.514 
                 0.99 
                 0.9 
               
               
                   
                 C14 
                 rs17776453 
                 100774793 
                 G 
                 1567/183 
                 0.956 
                 0.967 
                 1.37 
                 0.28 
               
               
                   
                 C01 
                 rs12724604 
                 20948045 
                 A 
                 1566/184 
                 0.044 
                 0.019 
                 0.42 
                 0.011 
               
               
                   
                 C05 
                 rs950195 
                 97466690 
                 G 
                 1565/184 
                 0.654 
                 0.679 
                 1.12 
                 0.34 
               
               
                   
                 C05 
                 rs728676 
                 118087433 
                 T 
                 1567/183 
                 0.462 
                 0.429 
                 0.87 
                 0.22 
               
               
                   
                 C06 
                 rs7739802 
                 162154323 
                 T 
                 1567/183 
                 0.549 
                 0.530 
                 0.92 
                 0.48 
               
               
                   
                 C10 
                 rs7086224 
                 30857283 
                 A 
                 1567/184 
                 0.418 
                 0.459 
                 1.18 
                 0.13 
               
               
                   
                 C01 
                 rs4845552 
                 151746622 
                 G 
                 1567/183 
                 0.125 
                 0.107 
                 0.83 
                 0.3 
               
               
                   
                 C08 
                 rs10504537 
                 73402234 
                 A 
                 1567/184 
                 0.866 
                 0.851 
                 0.88 
                 0.43 
               
               
                   
                 C02 
                 rs1395930 
                 123468570 
                 T 
                 1567/183 
                 0.539 
                 0.481 
                 0.79 
                 0.035 
               
               
                   
                 C02 
                 rs3943703 
                 127613790 
                 C 
                 1558/181 
                 0.228 
                 0.240 
                 1.07 
                 0.61 
               
               
                   
                 C10 
                 rs2279434 
                 45275070 
                 T 
                 1567/184 
                 0.075 
                 0.065 
                 0.86 
                 0.48 
               
               
                   
                 C10 
                 rs11198993 
                 85244450 
                 A 
                 1566/183 
                 0.786 
                 0.790 
                 1.02 
                 0.86 
               
               
                   
                 C10 
                 rs7921473 
                 85156395 
                 G 
                 1567/183 
                 0.844 
                 0.863 
                 1.17 
                 0.33 
               
               
                   
                 C12 
                 rs1465026 
                 65789635 
                 G 
                 1564/184 
                 0.836 
                 0.832 
                 0.97 
                 0.81 
               
               
                   
                 C12 
                 rs1568383 
                 88017285 
                 T 
                 1567/183 
                 0.117 
                 0.134 
                 1.17 
                 0.36 
               
               
                   
                 C08 
                 rs4732849 
                 28249765 
                 T 
                 1566/184 
                 0.310 
                 0.318 
                 1.04 
                 0.76 
               
               
                   
                 C08 
                 rs7006687 
                 18277862 
                 T 
                 1567/183 
                 0.558 
                 0.557 
                 1.00 
                 0.99 
               
               
                   
                 C02 
                 rs921083 
                 176453128 
                 G 
                 1567/182 
                 0.820 
                 0.788 
                 0.82 
                 0.15 
               
               
                   
                 C02 
                 rs6709904 
                 43933828 
                 A 
                 1561/184 
                 0.884 
                 0.856 
                 0.78 
                 0.12 
               
               
                   
                 C14 
                 rs1957860 
                 53499105 
                 T 
                 1567/183 
                 0.474 
                 0.459 
                 0.94 
                 0.57 
               
               
                   
                 C14 
                 rs4444235 
                 53480669 
                 T 
                 1567/183 
                 0.546 
                 0.552 
                 1.02 
                 0.83 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 WTCCC (14246/1926) 
                 Replication (19396/5182) 
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                   
                 Chr 
                 nc/na 
                 Ctr. fr 
                 Aff. fr 
                 OR 
                 P 
                 OR (99% CI) 
                 P 
               
               
                   
                   
               
               
                   
                 C06 
                 14237/1924 
                 0.173 
                 0.197 
                 1.17 
                 0.00026 
                 1.15 (1.08-1.22) 
                 2.87E−05 
               
               
                   
                 C10 
                 14223/1921 
                 0.316 
                 0.327 
                 1.05 
                 0.15 
                 1.07 (1.00-1.14) 
                 0.067 
               
               
                   
                 C10 
                   
                   
                   
                   
                   
                 1.09 (1.01-1.18) 
                 0.026 
               
               
                   
                 C01 
                 14220/1921 
                 0.251 
                 0.254 
                 1.01 
                 0.77 
                 1.04 (0.99-1.10) 
                 0.13 
               
               
                   
                 C11 
                 13841/1882 
                 0.482 
                 0.488 
                 1.02 
                 0.53 
                 1.03 (0.97-1.08) 
                 0.34 
               
               
                   
                 C05 
                 14239/1924 
                 0.201 
                 0.217 
                 1.10 
                 0.022 
                 1.09 (1.01-1.18) 
                 0.033 
               
               
                   
                 C17 
                 14239/1924 
                 0.350 
                 0.347 
                 0.99 
                 0.7 
                 1.03 (0.97-1.08) 
                 0.34 
               
               
                   
                 C20 
                 14220/1922 
                 0.312 
                 0.315 
                 1.01 
                 0.77 
                 1.03 (0.98-1.09) 
                 0.2 
               
               
                   
                 C05 
                 14243/1925 
                 0.182 
                 0.196 
                 1.09 
                 0.046 
                 1.06 (0.99-1.13) 
                 0.11 
               
               
                   
                 C05 
                 14239/1925 
                 0.354 
                 0.371 
                 1.08 
                 0.037 
                 1.06 (1.01-1.12) 
                 0.032 
               
               
                   
                 C19 
                   
                   
                   
                   
                   
                 1.01 (0.90-1.13) 
                 0.86 
               
               
                   
                 C07 
                 14243/1924 
                 0.084 
                 0.089 
                 1.06 
                 0.32 
                 1.09 (1.00-1.19) 
                 0.062 
               
               
                   
                 C17 
                 14241/1925 
                 0.375 
                 0.370 
                 0.98 
                 0.53 
                 1.02 (0.97-1.07) 
                 0.41 
               
               
                   
                 C17 
                 14215/1921 
                 0.405 
                 0.402 
                 0.99 
                 0.75 
                 1.03 (0.98-1.08) 
                 0.27 
               
               
                   
                 C14 
                   
                   
                   
                   
                   
                 1.04 (0.96-1.13) 
                 0.31 
               
               
                   
                 C10 
                 14219/1922 
                 0.520 
                 0.528 
                 1.03 
                 0.36 
                 1.04 (0.98-1.11) 
                 0.2 
               
               
                   
                 C17 
                 14243/1925 
                 0.350 
                 0.346 
                 0.99 
                 0.69 
                 1.02 (0.97-1.07) 
                 0.46 
               
               
                   
                 C17 
                 14242/1924 
                 0.348 
                 0.344 
                 0.98 
                 0.61 
                 1.01 (0.96-1.07) 
                 0.62 
               
               
                   
                 C17 
                 14242/1925 
                 0.394 
                 0.395 
                 1.00 
                 0.9 
                 1.02 (0.96-1.07) 
                 0.57 
               
               
                   
                 C05 
                 14242/1924 
                 0.164 
                 0.174 
                 1.07 
                 0.12 
                 1.07 (0.98-1.16) 
                 0.14 
               
               
                   
                 C07 
                 14241/1925 
                 0.096 
                 0.099 
                 1.03 
                 0.62 
                 1.06 (0.95-1.18) 
                 0.31 
               
               
                   
                 C12 
                 14243/1925 
                 0.717 
                 0.736 
                 1.10 
                 0.014 
                 1.06 (1.00-1.12) 
                 0.053 
               
               
                   
                 C20 
                 14212/1921 
                 0.397 
                 0.407 
                 1.04 
                 0.21 
                 1.04 (0.98-1.11) 
                 0.21 
               
               
                   
                 C06 
                 14241/1924 
                 0.431 
                 0.445 
                 1.06 
                 0.12 
                 1.03 (0.98-1.09) 
                 0.2 
               
               
                   
                 C07 
                 14237/1924 
                 0.252 
                 0.263 
                 1.06 
                 0.14 
                 1.04 (0.97-1.12) 
                 0.29 
               
               
                   
                 C05 
                 14228/1919 
                 0.106 
                 0.116 
                 1.10 
                 0.069 
                 1.08 (0.98-1.20) 
                 0.12 
               
               
                   
                 C15 
                 14222/1922 
                 0.074 
                 0.076 
                 1.04 
                 0.54 
                 1.05 (0.93-1.18) 
                 0.46 
               
               
                   
                 C05 
                 14228/1923 
                 0.628 
                 0.636 
                 1.04 
                 0.32 
                 1.04 (0.98-1.12) 
                 0.22 
               
               
                   
                 C05 
                 14240/1924 
                 0.290 
                 0.301 
                 1.06 
                 0.13 
                 1.06 (0.99-1.13) 
                 0.12 
               
               
                   
                 C17 
                 14240/1925 
                 0.310 
                 0.301 
                 0.96 
                 0.24 
                 0.99 (0.94-1.05) 
                 0.72 
               
               
                   
                 C11 
                 14211/1921 
                 0.510 
                 0.520 
                 1.04 
                 0.28 
                 1.04 (0.97-1.11) 
                 0.26 
               
               
                   
                 C05 
                 14240/1925 
                 0.483 
                 0.491 
                 1.03 
                 0.33 
                 1.04 (0.98-1.10) 
                 0.24 
               
               
                   
                 C17 
                 14222/1922 
                 0.333 
                 0.330 
                 0.98 
                 0.63 
                 1.00 (0.94-1.06) 
                 0.96 
               
               
                   
                 C05 
                 14233/1923 
                 0.178 
                 0.187 
                 1.06 
                 0.18 
                 1.05 (0.96-1.14) 
                 0.27 
               
               
                   
                 C05 
                 14232/1924 
                 0.301 
                 0.314 
                 1.07 
                 0.084 
                 1.03 (0.97-1.08) 
                 0.32 
               
               
                   
                 C02 
                 14218/1921 
                 0.441 
                 0.448 
                 1.03 
                 0.4 
                 1.03 (0.98-1.09) 
                 0.22 
               
               
                   
                 C01 
                 14219/1922 
                 0.560 
                 0.560 
                 1.00 
                 0.97 
                 1.00 (0.94-1.06) 
                 0.99 
               
               
                   
                 C04 
                 14242/1924 
                 0.449 
                 0.437 
                 0.95 
                 0.14 
                 0.97 (0.92-1.03) 
                 0.39 
               
               
                   
                 C05 
                 14236/1924 
                 0.607 
                 0.628 
                 1.09 
                 0.013 
                 1.03 (0.97-1.09) 
                 0.29 
               
               
                   
                 C06 
                 14241/1925 
                 0.157 
                 0.154 
                 0.97 
                 0.55 
                 1.00 (0.92-1.08) 
                 0.91 
               
               
                   
                 C05 
                 14242/1925 
                 0.945 
                 0.946 
                 1.03 
                 0.68 
                 1.04 (0.90-1.20) 
                 0.59 
               
               
                   
                 C10 
                 14240/1925 
                 0.373 
                 0.390 
                 1.08 
                 0.035 
                 1.03 (0.97-1.08) 
                 0.35 
               
               
                   
                 C15 
                 14237/1925 
                 0.058 
                 0.059 
                 1.02 
                 0.78 
                 1.00 (0.88-1.14) 
                 0.98 
               
               
                   
                 C02 
                 14239/1925 
                 0.656 
                 0.667 
                 1.05 
                 0.19 
                 1.02 (0.97-1.08) 
                 0.4 
               
               
                   
                 C14 
                 14075/1906 
                 0.153 
                 0.162 
                 1.07 
                 0.18 
                 1.04 (0.96-1.12) 
                 0.34 
               
               
                   
                 C21 
                 14236/1924 
                 0.230 
                 0.231 
                 1.00 
                 0.97 
                 1.00 (0.93-1.08) 
                 0.99 
               
               
                   
                 C05 
                 14246/1925 
                 0.193 
                 0.212 
                 1.13 
                 0.0051 
                 1.03 (0.96-1.10) 
                 0.41 
               
               
                   
                 C08 
                 14241/1924 
                 0.928 
                 0.920 
                 0.89 
                 0.084 
                 0.94 (0.84-1.04) 
                 0.23 
               
               
                   
                 C01 
                 14238/1924 
                 0.121 
                 0.108 
                 0.88 
                 0.02 
                 0.97 (0.89-1.05) 
                 0.45 
               
               
                   
                 C13 
                 14214/1921 
                 0.474 
                 0.471 
                 0.99 
                 0.72 
                 1.00 (0.95-1.05) 
                 1 
               
               
                   
                 C08 
                 14242/1925 
                 0.623 
                 0.625 
                 1.01 
                 0.83 
                 1.02 (0.96-1.09) 
                 0.53 
               
               
                   
                 C08 
                 14241/1925 
                 0.623 
                 0.625 
                 1.01 
                 0.83 
                 1.02 (0.96-1.09) 
                 0.53 
               
               
                   
                 C01 
                 14236/1925 
                 0.903 
                 0.907 
                 1.05 
                 0.38 
                 1.07 (0.95-1.19) 
                 0.26 
               
               
                   
                 C04 
                 14242/1924 
                 0.506 
                 0.505 
                 0.99 
                 0.84 
                 1.00 (0.94-1.06) 
                 0.97 
               
               
                   
                 C16 
                 14192/1918 
                 0.407 
                 0.406 
                 1.00 
                 0.96 
                 1.01 (0.95-1.07) 
                 0.81 
               
               
                   
                 C16 
                 14243/1925 
                 0.406 
                 0.406 
                 1.00 
                 0.99 
                 1.01 (0.95-1.06) 
                 0.82 
               
               
                   
                 C17 
                 14222/1922 
                 0.260 
                 0.250 
                 0.95 
                 0.2 
                 0.98 (0.92-1.04) 
                 0.51 
               
               
                   
                 C10 
                 14241/1925 
                 0.377 
                 0.380 
                 1.01 
                 0.73 
                 1.03 (0.96-1.10) 
                 0.4 
               
               
                   
                 C12 
                 14234/1924 
                 0.137 
                 0.131 
                 0.95 
                 0.34 
                 0.99 (0.92-1.07) 
                 0.81 
               
               
                   
                 C05 
                 14240/1924 
                 0.317 
                 0.319 
                 1.01 
                 0.82 
                 1.02 (0.97-1.08) 
                 0.35 
               
               
                   
                 C09 
                   
                   
                   
                   
                   
                 0.93 (0.84-1.04) 
                 0.2 
               
               
                   
                 C16 
                 14224/1922 
                 0.637 
                 0.638 
                 1.00 
                 0.91 
                 1.00 (0.93-1.07) 
                 0.94 
               
               
                   
                 C06 
                 14224/1922 
                 0.331 
                 0.326 
                 0.98 
                 0.55 
                 0.98 (0.92-1.05) 
                 0.6 
               
               
                   
                 C12 
                 14235/1924 
                 0.356 
                 0.358 
                 1.01 
                 0.84 
                 1.01 (0.96-1.07) 
                 0.75 
               
               
                   
                 C13 
                 14241/1925 
                 0.176 
                 0.177 
                 1.01 
                 0.79 
                 1.02 (0.94-1.11) 
                 0.6 
               
               
                   
                 C18 
                 14226/1922 
                 0.597 
                 0.599 
                 1.01 
                 0.81 
                 1.01 (0.97-1.07) 
                 0.56 
               
               
                   
                 C18 
                 13709/1832 
                 0.188 
                 0.192 
                 1.03 
                 0.52 
                 1.02 (0.93-1.10) 
                 0.72 
               
               
                   
                 C06 
                 14219/1921 
                 0.628 
                 0.628 
                 1.00 
                 0.99 
                 0.99 (0.93-1.06) 
                 0.87 
               
               
                   
                 C12 
                 14239/1924 
                 0.897 
                 0.898 
                 1.01 
                 0.88 
                 1.01 (0.92-1.11) 
                 0.85 
               
               
                   
                 C03 
                 14223/1921 
                 0.670 
                 0.669 
                 0.99 
                 0.84 
                 1.01 (0.96-1.07) 
                 0.63 
               
               
                   
                 C14 
                 14234/1923 
                 0.274 
                 0.268 
                 0.97 
                 0.41 
                 0.96 (0.89-1.03) 
                 0.24 
               
               
                   
                 C02 
                 14241/1924 
                 0.762 
                 0.754 
                 0.96 
                 0.29 
                 0.97 (0.91-1.03) 
                 0.35 
               
               
                   
                 C04 
                 14230/1923 
                 0.671 
                 0.674 
                 1.02 
                 0.68 
                 1.00 (0.94-1.08) 
                 0.9 
               
               
                   
                 C01 
                 14219/1921 
                 0.399 
                 0.392 
                 0.97 
                 0.38 
                 0.97 (0.92-1.03) 
                 0.37 
               
               
                   
                 C04 
                 14229/1923 
                 0.540 
                 0.533 
                 0.97 
                 0.4 
                 0.98 (0.93-1.03) 
                 0.43 
               
               
                   
                 C06 
                 14229/1923 
                 0.365 
                 0.362 
                 0.99 
                 0.73 
                 0.99 (0.93-1.06) 
                 0.85 
               
               
                   
                 C10 
                 14246/1925 
                 0.650 
                 0.650 
                 1.00 
                 0.99 
                 0.99 (0.94-1.05) 
                 0.84 
               
               
                   
                 C13 
                 14222/1922 
                 0.510 
                 0.510 
                 1.00 
                 0.95 
                 0.99 (0.94-1.05) 
                 0.84 
               
               
                   
                 C08 
                 14236/1924 
                 0.533 
                 0.536 
                 1.01 
                 0.74 
                 1.03 (0.98-1.09) 
                 0.28 
               
               
                   
                 C14 
                 14231/1923 
                 0.923 
                 0.923 
                 1.00 
                 0.97 
                 1.01 (0.90-1.14) 
                 0.85 
               
               
                   
                 C01 
                 14244/1925 
                 0.041 
                 0.040 
                 0.96 
                 0.66 
                 0.92 (0.78-1.08) 
                 0.3 
               
               
                   
                 C05 
                 14236/1924 
                 0.649 
                 0.647 
                 0.99 
                 0.82 
                 0.97 (0.92-1.03) 
                 0.34 
               
               
                   
                 C05 
                 14223/1923 
                 0.484 
                 0.471 
                 0.95 
                 0.14 
                 0.97 (0.92-1.02) 
                 0.28 
               
               
                   
                 C06 
                 14219/1922 
                 0.624 
                 0.620 
                 0.98 
                 0.64 
                 0.98 (0.92-1.04) 
                 0.51 
               
               
                   
                 C10 
                 14217/1921 
                 0.450 
                 0.441 
                 0.96 
                 0.26 
                 0.98 (0.92-1.04) 
                 0.53 
               
               
                   
                 C01 
                 14237/1924 
                 0.139 
                 0.135 
                 0.97 
                 0.51 
                 0.95 (0.88-1.03) 
                 0.23 
               
               
                   
                 C08 
                 14233/1923 
                 0.871 
                 0.868 
                 0.98 
                 0.68 
                 0.97 (0.88-1.07) 
                 0.53 
               
               
                   
                 C02 
                 14242/1925 
                 0.498 
                 0.495 
                 0.99 
                 0.71 
                 0.98 (0.93-1.02) 
                 0.32 
               
               
                   
                 C02 
                 14171/1913 
                 0.233 
                 0.222 
                 0.94 
                 0.14 
                 0.95 (0.88-1.03) 
                 0.21 
               
               
                   
                 C10 
                 14239/1924 
                 0.085 
                 0.081 
                 0.95 
                 0.42 
                 0.92 (0.83-1.02) 
                 0.11 
               
               
                   
                 C10 
                 14241/1924 
                 0.780 
                 0.772 
                 0.95 
                 0.23 
                 0.97 (0.91-1.03) 
                 0.28 
               
               
                   
                 C10 
                 14241/1923 
                 0.857 
                 0.845 
                 0.91 
                 0.05 
                 0.93 (0.86-1.00) 
                 0.054 
               
               
                   
                 C12 
                 14240/1925 
                 0.836 
                 0.829 
                 0.95 
                 0.3 
                 0.96 (0.89-1.03) 
                 0.21 
               
               
                   
                 C12 
                 14238/1924 
                 0.111 
                 0.104 
                 0.92 
                 0.14 
                 0.93 (0.85-1.02) 
                 0.12 
               
               
                   
                 C08 
                 14240/1926 
                 0.328 
                 0.315 
                 0.94 
                 0.11 
                 0.96 (0.91-1.02) 
                 0.16 
               
               
                   
                 C08 
                 14221/1922 
                 0.556 
                 0.550 
                 0.97 
                 0.44 
                 0.94 (0.89-1.00) 
                 0.034 
               
               
                   
                 C02 
                 14215/1922 
                 0.731 
                 0.717 
                 0.93 
                 0.061 
                 0.95 (0.90-1.01) 
                 0.099 
               
               
                   
                 C02 
                 14233/1924 
                 0.900 
                 0.896 
                 0.96 
                 0.47 
                 0.94 (0.85-1.03) 
                 0.19 
               
               
                   
                 C14 
                 14238/1923 
                 0.473 
                 0.482 
                 1.03 
                 0.32 
                 1.03 (0.98-1.08) 
                 0.26 
               
               
                   
                 C14 
                 14232/1923 
                 0.537 
                 0.536 
                 0.99 
                 0.86 
                 0.98 (0.93-1.03) 
                 0.36 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Table 4F - CAD 
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Pos in Build 
                   
                 Hopkins (1567/389) 
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                   
                 Chr 
                 SNP 
                 36 
                 Allele 
                 nc/na 
                 Ctr. fr 
                 Aff. fr 
                 OR 
                 P 
               
               
                   
                   
               
               
                   
                 C06 
                 rs11751605 
                 160883220 
                 C 
                 1565/389 
                 0.155 
                 0.180 
                 1.20 
                 0.093 
               
               
                   
                 C20 
                 rs6076623 
                 4084671 
                 T 
                 1567/388 
                 0.296 
                 0.331 
                 1.18 
                 0.059 
               
               
                   
                 C10 
                 rs1412444 
                 90992907 
                 A 
                 1565/388 
                 0.321 
                 0.345 
                 1.11 
                 0.2 
               
               
                   
                 C11 
                 rs2163612 
                 82856844 
                 G 
                 1566/387 
                 0.497 
                 0.506 
                 1.04 
                 0.63 
               
               
                   
                 C07 
                 rs1029396 
                 116812056 
                 G 
                 1566/388 
                 0.080 
                 0.110 
                 1.42 
                 0.0092 
               
               
                   
                 C10 
                 rs2243547 
                 91000459 
                 G 
                 1539/387 
                 0.284 
                 0.317 
                 1.17 
                 0.076 
               
               
                   
                 C07 
                 rs12534186 
                 117079572 
                 T 
                 1567/389 
                 0.095 
                 0.112 
                 1.20 
                 0.17 
               
               
                   
                 C01 
                 rs12134779 
                 63168930 
                 T 
                 1567/388 
                 0.265 
                 0.278 
                 1.07 
                 0.47 
               
               
                   
                 C14 
                 rs7158073 
                 99211442 
                 T 
                 1509/379 
                 0.431 
                 0.437 
                 1.02 
                 0.79 
               
               
                   
                 C05 
                 rs254850 
                 158599309 
                 T 
                 1567/389 
                 0.195 
                 0.190 
                 0.97 
                 0.76 
               
               
                   
                 C12 
                 rs2417821 
                 20081535 
                 T 
                 1566/389 
                 0.728 
                 0.729 
                 1.00 
                 0.98 
               
               
                   
                 C04 
                 rs7661204 
                 45728007 
                 T 
                 1567/388 
                 0.410 
                 0.374 
                 0.86 
                 0.064 
               
               
                   
                 C05 
                 rs4921437 
                 158623529 
                 T 
                 1566/388 
                 0.184 
                 0.182 
                 0.98 
                 0.87 
               
               
                   
                 C05 
                 rs832540 
                 56234959 
                 C 
                 1567/389 
                 0.361 
                 0.365 
                 1.02 
                 0.84 
               
               
                   
                 C07 
                 rs324594 
                 136305863 
                 C 
                 1567/387 
                 0.269 
                 0.267 
                 0.99 
                 0.92 
               
               
                   
                 C20 
                 rs1741318 
                 4105600 
                 A 
                 1566/388 
                 0.377 
                 0.374 
                 0.99 
                 0.88 
               
               
                   
                 C17 
                 rs9902941 
                 17674485 
                 C 
                 1567/387 
                 0.367 
                 0.368 
                 1.00 
                 0.96 
               
               
                   
                 C05 
                 rs7709212 
                 158696755 
                 T 
                 1567/388 
                 0.674 
                 0.700 
                 1.13 
                 0.17 
               
               
                   
                 C01 
                 rs2946534 
                 18647370 
                 T 
                 1564/388 
                 0.548 
                 0.581 
                 1.15 
                 0.092 
               
               
                   
                 C05 
                 rs6556861 
                 94554256 
                 G 
                 1567/388 
                 0.623 
                 0.610 
                 0.94 
                 0.48 
               
               
                   
                 C16 
                 rs8050136 
                 52373776 
                 A 
                 1567/388 
                 0.411 
                 0.418 
                 1.03 
                 0.75 
               
               
                   
                 C16 
                 rs3751812 
                 52375961 
                 T 
                 1567/389 
                 0.410 
                 0.418 
                 1.03 
                 0.68 
               
               
                   
                 C13 
                 rs4769613 
                 28036609 
                 T 
                 1567/388 
                 0.469 
                 0.514 
                 1.20 
                 0.024 
               
               
                   
                 C10 
                 rs2243548 
                 91000293 
                 A 
                 1566/388 
                 0.504 
                 0.522 
                 1.07 
                 0.38 
               
               
                   
                 C19 
                 rs12459084 
                 17031885 
                 T 
                 1512/381 
                 0.415 
                 0.423 
                 1.03 
                 0.69 
               
               
                   
                 C06 
                 rs2074464 
                 29516507 
                 T 
                 1562/388 
                 0.447 
                 0.452 
                 1.02 
                 0.77 
               
               
                   
                 C02 
                 rs2244871 
                 128115310 
                 C 
                 1556/385 
                 0.426 
                 0.425 
                 0.99 
                 0.94 
               
               
                   
                 C05 
                 rs270654 
                 158497687 
                 G 
                 1567/388 
                 0.108 
                 0.095 
                 0.87 
                 0.32 
               
               
                   
                 C17 
                 rs854787 
                 17975744 
                 C 
                 1552/385 
                 0.428 
                 0.429 
                 1.00 
                 0.96 
               
               
                   
                 C11 
                 rs7944761 
                 1361414 
                 T 
                 1567/389 
                 0.563 
                 0.539 
                 0.90 
                 0.21 
               
               
                   
                 C15 
                 rs4779984 
                 30302218 
                 G 
                 1562/388 
                 0.125 
                 0.121 
                 0.96 
                 0.76 
               
               
                   
                 C17 
                 rs6502622 
                 17775416 
                 G 
                 1563/388 
                 0.401 
                 0.397 
                 0.99 
                 0.85 
               
               
                   
                 C17 
                 rs3183702 
                 17688014 
                 T 
                 1561/388 
                 0.365 
                 0.365 
                 1.00 
                 0.99 
               
               
                   
                 C05 
                 rs1433048 
                 158688423 
                 G 
                 1565/388 
                 0.184 
                 0.178 
                 0.96 
                 0.67 
               
               
                   
                 C17 
                 rs4925119 
                 17683629 
                 A 
                 1542/383 
                 0.361 
                 0.362 
                 1.00 
                 0.97 
               
               
                   
                 C01 
                 rs2476601 
                 114179091 
                 A 
                 1566/388 
                 0.091 
                 0.097 
                 1.07 
                 0.63 
               
               
                   
                 C05 
                 rs870347 
                 6898035 
                 T 
                 1566/389 
                 0.940 
                 0.945 
                 1.09 
                 0.61 
               
               
                   
                 C08 
                 rs334198 
                 18933089 
                 C 
                 1566/389 
                 0.922 
                 0.914 
                 0.89 
                 0.43 
               
               
                   
                 C17 
                 rs854813 
                 17944570 
                 C 
                 1551/383 
                 0.409 
                 0.413 
                 1.02 
                 0.85 
               
               
                   
                 C06 
                 rs7753765 
                 71732495 
                 A 
                 1567/389 
                 0.170 
                 0.163 
                 0.95 
                 0.66 
               
               
                   
                 C17 
                 rs4925114 
                 17651995 
                 A 
                 1561/388 
                 0.372 
                 0.367 
                 0.98 
                 0.82 
               
               
                   
                 C05 
                 rs270661 
                 158492732 
                 A 
                 1567/389 
                 0.194 
                 0.179 
                 0.91 
                 0.34 
               
               
                   
                 C05 
                 rs953861 
                 158705160 
                 G 
                 1565/389 
                 0.168 
                 0.162 
                 0.95 
                 0.67 
               
               
                   
                 C05 
                 rs10045431 
                 158747111 
                 A 
                 1567/389 
                 0.289 
                 0.298 
                 1.04 
                 0.62 
               
               
                   
                 C14 
                 rs8003722 
                 68388015 
                 A 
                 1566/388 
                 0.138 
                 0.146 
                 1.07 
                 0.57 
               
               
                   
                 C09 
                 rs2297538 
                 138684489 
                 G 
                 1555/381 
                 0.791 
                 0.797 
                 1.03 
                 0.75 
               
               
                   
                 C02 
                 rs12329252 
                 212093968 
                 T 
                 1567/388 
                 0.657 
                 0.680 
                 1.11 
                 0.22 
               
               
                   
                 C01 
                 rs3748744 
                 19828833 
                 G 
                 1561/387 
                 0.896 
                 0.898 
                 1.03 
                 0.85 
               
               
                   
                 C05 
                 rs4704400 
                 76586766 
                 T 
                 1563/388 
                 0.485 
                 0.476 
                 0.96 
                 0.64 
               
               
                   
                 C08 
                 rs3102526 
                 96858538 
                 G 
                 1565/388 
                 0.620 
                 0.628 
                 1.03 
                 0.69 
               
               
                   
                 C15 
                 rs2110209 
                 24946433 
                 A 
                 1567/389 
                 0.031 
                 0.030 
                 0.94 
                 0.8 
               
               
                   
                 C16 
                 rs1870843 
                 81316815 
                 T 
                 1567/389 
                 0.603 
                 0.603 
                 1.00 
                 0.99 
               
               
                   
                 C08 
                 rs3134517 
                 96859237 
                 G 
                 1567/389 
                 0.620 
                 0.627 
                 1.03 
                 0.7 
               
               
                   
                 C21 
                 rs2828495 
                 24038081 
                 A 
                 1566/388 
                 0.233 
                 0.201 
                 0.83 
                 0.056 
               
               
                   
                 C04 
                 rs4282162 
                 21426819 
                 T 
                 1567/388 
                 0.503 
                 0.503 
                 1.00 
                 1 
               
               
                   
                 C17 
                 rs2955355 
                 17889200 
                 C 
                 1565/388 
                 0.318 
                 0.326 
                 1.04 
                 0.65 
               
               
                   
                 C12 
                 rs11045689 
                 21092930 
                 G 
                 1557/386 
                 0.346 
                 0.325 
                 0.91 
                 0.26 
               
               
                   
                 C05 
                 rs7447732 
                 158461713 
                 C 
                 1566/389 
                 0.321 
                 0.319 
                 0.99 
                 0.91 
               
               
                   
                 C18 
                 rs1365254 
                 70238283 
                 T 
                 1567/389 
                 0.187 
                 0.180 
                 0.96 
                 0.67 
               
               
                   
                 C13 
                 rs1887263 
                 22381716 
                 A 
                 1567/389 
                 0.174 
                 0.180 
                 1.04 
                 0.71 
               
               
                   
                 C12 
                 rs12304836 
                 124654446 
                 C 
                 1567/389 
                 0.151 
                 0.138 
                 0.90 
                 0.34 
               
               
                   
                 C05 
                 rs38055 
                 52596401 
                 T 
                 1567/389 
                 0.340 
                 0.324 
                 0.93 
                 0.39 
               
               
                   
                 C04 
                 rs4697653 
                 10337857 
                 G 
                 1553/386 
                 0.567 
                 0.580 
                 1.06 
                 0.5 
               
               
                   
                 C05 
                 rs728676 
                 118087433 
                 T 
                 1567/388 
                 0.462 
                 0.461 
                 1.00 
                 0.96 
               
               
                   
                 C06 
                 rs6905466 
                 19958854 
                 T 
                 1567/388 
                 0.338 
                 0.335 
                 0.99 
                 0.88 
               
               
                   
                 C10 
                 rs11199158 
                 85297471 
                 G 
                 1566/388 
                 0.645 
                 0.621 
                 0.90 
                 0.22 
               
               
                   
                 C01 
                 rs4845552 
                 151746622 
                 G 
                 1567/388 
                 0.125 
                 0.117 
                 0.93 
                 0.55 
               
               
                   
                 C02 
                 rs1395930 
                 123468570 
                 T 
                 1567/388 
                 0.539 
                 0.514 
                 0.91 
                 0.22 
               
               
                   
                 C04 
                 rs6534683 
                 129601758 
                 T 
                 1567/388 
                 0.652 
                 0.635 
                 0.93 
                 0.38 
               
               
                   
                 C02 
                 rs6747236 
                 35901725 
                 T 
                 1566/389 
                 0.755 
                 0.754 
                 0.99 
                 0.96 
               
               
                   
                 C06 
                 rs3016536 
                 162157939 
                 G 
                 1567/388 
                 0.596 
                 0.573 
                 0.91 
                 0.26 
               
               
                   
                 C10 
                 rs12269612 
                 15475877 
                 T 
                 1567/389 
                 0.376 
                 0.362 
                 0.94 
                 0.49 
               
               
                   
                 C17 
                 rs854793 
                 17971249 
                 A 
                 1567/388 
                 0.232 
                 0.237 
                 1.03 
                 0.75 
               
               
                   
                 C12 
                 rs3742049 
                 119438873 
                 C 
                 1565/388 
                 0.885 
                 0.879 
                 0.94 
                 0.64 
               
               
                   
                 C01 
                 rs2991515 
                 57656898 
                 T 
                 1565/389 
                 0.458 
                 0.428 
                 0.88 
                 0.13 
               
               
                   
                 C18 
                 rs4271662 
                 26051291 
                 C 
                 1567/388 
                 0.595 
                 0.601 
                 1.02 
                 0.78 
               
               
                   
                 C06 
                 rs7739802 
                 162154323 
                 T 
                 1567/388 
                 0.549 
                 0.531 
                 0.93 
                 0.35 
               
               
                   
                 C08 
                 rs10504537 
                 73402234 
                 A 
                 1567/388 
                 0.866 
                 0.865 
                 0.99 
                 0.94 
               
               
                   
                 C14 
                 rs17776453 
                 100774793 
                 G 
                 1567/388 
                 0.956 
                 0.954 
                 0.95 
                 0.81 
               
               
                   
                 C10 
                 rs7086224 
                 30857283 
                 A 
                 1567/389 
                 0.418 
                 0.450 
                 1.14 
                 0.11 
               
               
                   
                 C01 
                 rs12724604 
                 20948045 
                 A 
                 1566/389 
                 0.044 
                 0.037 
                 0.83 
                 0.37 
               
               
                   
                 C03 
                 rs9874646 
                 62437858 
                 T 
                 1567/388 
                 0.669 
                 0.673 
                 1.01 
                 0.86 
               
               
                   
                 C05 
                 rs950195 
                 97466690 
                 G 
                 1565/389 
                 0.654 
                 0.657 
                 1.01 
                 0.9 
               
               
                   
                 C14 
                 rs2281519 
                 93846385 
                 T 
                 1564/388 
                 0.267 
                 0.254 
                 0.93 
                 0.45 
               
               
                   
                 C10 
                 rs4880711 
                 5217871 
                 C 
                 1562/388 
                 0.349 
                 0.343 
                 0.97 
                 0.76 
               
               
                   
                 C08 
                 rs3931282 
                 129179963 
                 T 
                 1567/389 
                 0.517 
                 0.528 
                 1.05 
                 0.57 
               
               
                   
                 C10 
                 rs11198993 
                 85244450 
                 A 
                 1566/388 
                 0.786 
                 0.764 
                 0.88 
                 0.2 
               
               
                   
                 C12 
                 rs1568383 
                 88017285 
                 T 
                 1567/388 
                 0.117 
                 0.125 
                 1.08 
                 0.54 
               
               
                   
                 C06 
                 rs9380681 
                 37638433 
                 C 
                 1567/388 
                 0.315 
                 0.325 
                 1.04 
                 0.61 
               
               
                   
                 C02 
                 rs6709904 
                 43933828 
                 A 
                 1561/388 
                 0.884 
                 0.871 
                 0.88 
                 0.31 
               
               
                   
                 C10 
                 rs2279434 
                 45275070 
                 T 
                 1567/389 
                 0.075 
                 0.077 
                 1.03 
                 0.86 
               
               
                   
                 C13 
                 rs1375719 
                 102208783 
                 C 
                 1566/388 
                 0.492 
                 0.492 
                 1.00 
                 0.98 
               
               
                   
                 C10 
                 rs7921473 
                 85156395 
                 G 
                 1567/387 
                 0.844 
                 0.840 
                 0.97 
                 0.76 
               
               
                   
                 C14 
                 rs1957860 
                 53499105 
                 T 
                 1567/388 
                 0.474 
                 0.481 
                 1.03 
                 0.76 
               
               
                   
                 C02 
                 rs3943703 
                 127613790 
                 C 
                 1558/385 
                 0.228 
                 0.232 
                 1.02 
                 0.81 
               
               
                   
                 C08 
                 rs7006687 
                 18277862 
                 T 
                 1567/388 
                 0.558 
                 0.550 
                 0.97 
                 0.71 
               
               
                   
                 C12 
                 rs1465026 
                 65789635 
                 G 
                 1564/389 
                 0.836 
                 0.832 
                 0.97 
                 0.75 
               
               
                   
                 C14 
                 rs4444235 
                 53480669 
                 T 
                 1567/388 
                 0.546 
                 0.523 
                 0.91 
                 0.26 
               
               
                   
                 C02 
                 rs921083 
                 176453128 
                 G 
                 1567/387 
                 0.820 
                 0.796 
                 0.86 
                 0.12 
               
               
                   
                 C08 
                 rs4732849 
                 28249765 
                 T 
                 1566/389 
                 0.310 
                 0.320 
                 1.05 
                 0.59 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 WTCCC (14246/1926) 
                 Replication (19396/6108) 
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                   
                 Chr 
                 nc/na 
                 Ctr. fr 
                 Aff. fr 
                 OR 
                 P 
                 OR (95% CI) 
                 P 
               
               
                   
                   
               
               
                   
                 C06 
                 14237/1924 
                 0.173 
                 0.197 
                 1.17 
                 0.00026 
                 1.15 (1.08-1.22) 
                 7.33E−06 
               
               
                   
                 C20 
                 14220/1922 
                 0.312 
                 0.315 
                 1.01 
                 0.77 
                 1.04 (0.99-1.09) 
                 0.12 
               
               
                   
                 C10 
                   
                   
                   
                   
                   
                 1.09 (1.02-1.17) 
                 0.013 
               
               
                   
                 C11 
                 13841/1882 
                 0.482 
                 0.488 
                 1.02 
                 0.53 
                 1.03 (0.98-1.09) 
                 0.2 
               
               
                   
                 C07 
                 14243/1924 
                 0.084 
                 0.089 
                 1.06 
                 0.32 
                 1.08 (0.99-1.18) 
                 0.066 
               
               
                   
                 C10 
                 14223/1921 
                 0.316 
                 0.327 
                 1.05 
                 0.15 
                 1.07 (1.00-1.14) 
                 0.045 
               
               
                   
                 C07 
                 14241/1925 
                 0.096 
                 0.099 
                 1.03 
                 0.62 
                 1.05 (0.95-1.17) 
                 0.31 
               
               
                   
                 C01 
                 14220/1921 
                 0.251 
                 0.254 
                 1.01 
                 0.77 
                 1.04 (0.99-1.10) 
                 0.1 
               
               
                   
                 C14 
                   
                   
                   
                   
                   
                 1.05 (0.98-1.13) 
                 0.15 
               
               
                   
                 C05 
                 14239/1924 
                 0.201 
                 0.217 
                 1.10 
                 0.022 
                 1.08 (1.00-1.17) 
                 0.045 
               
               
                   
                 C12 
                 14243/1925 
                 0.717 
                 0.736 
                 1.10 
                 0.014 
                 1.06 (1.00-1.12) 
                 0.057 
               
               
                   
                 C04 
                 14242/1924 
                 0.449 
                 0.437 
                 0.95 
                 0.14 
                 0.96 (0.91-1.02) 
                 0.21 
               
               
                   
                 C05 
                 14243/1925 
                 0.182 
                 0.196 
                 1.09 
                 0.046 
                 1.05 (0.99-1.13) 
                 0.11 
               
               
                   
                 C05 
                 14239/1925 
                 0.354 
                 0.371 
                 1.08 
                 0.037 
                 1.05 (1.00-1.11) 
                 0.074 
               
               
                   
                 C07 
                 14237/1924 
                 0.252 
                 0.263 
                 1.06 
                 0.14 
                 1.05 (0.98-1.12) 
                 0.19 
               
               
                   
                 C20 
                 14212/1921 
                 0.397 
                 0.407 
                 1.04 
                 0.21 
                 1.04 (0.97-1.10) 
                 0.28 
               
               
                   
                 C17 
                 14239/1924 
                 0.350 
                 0.347 
                 0.99 
                 0.7 
                 1.03 (0.98-1.08) 
                 0.27 
               
               
                   
                 C05 
                 14228/1923 
                 0.628 
                 0.636 
                 1.04 
                 0.32 
                 1.05 (0.98-1.12) 
                 0.15 
               
               
                   
                 C01 
                 14219/1922 
                 0.560 
                 0.560 
                 1.00 
                 0.97 
                 1.02 (0.96-1.08) 
                 0.54 
               
               
                   
                 C05 
                 14236/1924 
                 0.607 
                 0.628 
                 1.09 
                 0.013 
                 1.04 (0.99-1.10) 
                 0.14 
               
               
                   
                 C16 
                 14192/1918 
                 0.407 
                 0.406 
                 1.00 
                 0.96 
                 1.02 (0.96-1.07) 
                 0.56 
               
               
                   
                 C16 
                 14243/1925 
                 0.406 
                 0.406 
                 1.00 
                 0.99 
                 1.02 (0.96-1.07) 
                 0.58 
               
               
                   
                 C13 
                 14214/1921 
                 0.474 
                 0.471 
                 0.99 
                 0.72 
                 1.01 (0.96-1.06) 
                 0.77 
               
               
                   
                 C10 
                 14219/1922 
                 0.520 
                 0.528 
                 1.03 
                 0.36 
                 1.04 (0.98-1.10) 
                 0.24 
               
               
                   
                 C19 
                   
                   
                   
                   
                   
                 1.00 (0.91-1.11) 
                 0.94 
               
               
                   
                 C06 
                 14241/1924 
                 0.431 
                 0.445 
                 1.06 
                 0.12 
                 1.03 (0.98-1.08) 
                 0.23 
               
               
                   
                 C02 
                 14218/1921 
                 0.441 
                 0.448 
                 1.03 
                 0.4 
                 1.04 (0.98-1.09) 
                 0.17 
               
               
                   
                 C05 
                 14228/1919 
                 0.106 
                 0.116 
                 1.10 
                 0.069 
                 1.07 (0.97-1.18) 
                 0.19 
               
               
                   
                 C17 
                 14215/1921 
                 0.405 
                 0.402 
                 0.99 
                 0.75 
                 1.03 (0.98-1.08) 
                 0.3 
               
               
                   
                 C11 
                 14211/1921 
                 0.510 
                 0.520 
                 1.04 
                 0.28 
                 1.02 (0.96-1.08) 
                 0.61 
               
               
                   
                 C15 
                 14222/1922 
                 0.074 
                 0.076 
                 1.04 
                 0.54 
                 1.02 (0.91-1.14) 
                 0.69 
               
               
                   
                 C17 
                 14241/1925 
                 0.375 
                 0.370 
                 0.98 
                 0.53 
                 1.02 (0.97-1.07) 
                 0.47 
               
               
                   
                 C17 
                 14242/1924 
                 0.348 
                 0.344 
                 0.98 
                 0.61 
                 1.01 (0.96-1.06) 
                 0.6 
               
               
                   
                 C05 
                 14233/1923 
                 0.178 
                 0.187 
                 1.06 
                 0.18 
                 1.04 (0.96-1.13) 
                 0.29 
               
               
                   
                 C17 
                 14243/1925 
                 0.350 
                 0.346 
                 0.99 
                 0.69 
                 1.02 (0.97-1.07) 
                 0.5 
               
               
                   
                 C01 
                 14238/1924 
                 0.121 
                 0.108 
                 0.88 
                 0.02 
                 0.98 (0.91-1.06) 
                 0.68 
               
               
                   
                 C05 
                 14242/1925 
                 0.945 
                 0.946 
                 1.03 
                 0.68 
                 1.04 (0.91-1.19) 
                 0.56 
               
               
                   
                 C08 
                 14241/1924 
                 0.928 
                 0.920 
                 0.89 
                 0.084 
                 0.92 (0.83-1.02) 
                 0.11 
               
               
                   
                 C17 
                 14242/1925 
                 0.394 
                 0.395 
                 1.00 
                 0.9 
                 1.02 (0.97-1.07) 
                 0.54 
               
               
                   
                 C06 
                 14241/1925 
                 0.157 
                 0.154 
                 0.97 
                 0.55 
                 0.97 (0.90-1.05) 
                 0.5 
               
               
                   
                 C17 
                 14222/1922 
                 0.333 
                 0.330 
                 0.98 
                 0.63 
                 1.01 (0.95-1.07) 
                 0.82 
               
               
                   
                 C05 
                 14246/1925 
                 0.193 
                 0.212 
                 1.13 
                 0.0051 
                 1.03 (0.97-1.10) 
                 0.29 
               
               
                   
                 C05 
                 14242/1924 
                 0.164 
                 0.174 
                 1.07 
                 0.12 
                 1.05 (0.97-1.15) 
                 0.21 
               
               
                   
                 C05 
                 14240/1924 
                 0.290 
                 0.301 
                 1.06 
                 0.13 
                 1.06 (0.99-1.13) 
                 0.11 
               
               
                   
                 C14 
                 14075/1906 
                 0.153 
                 0.162 
                 1.07 
                 0.18 
                 1.04 (0.97-1.12) 
                 0.28 
               
               
                   
                 C09 
                   
                   
                   
                   
                   
                 0.96 (0.87-1.05) 
                 0.34 
               
               
                   
                 C02 
                 14239/1925 
                 0.656 
                 0.667 
                 1.05 
                 0.19 
                 1.02 (0.97-1.07) 
                 0.53 
               
               
                   
                 C01 
                 14236/1925 
                 0.903 
                 0.907 
                 1.05 
                 0.38 
                 1.05 (0.94-1.16) 
                 0.38 
               
               
                   
                 C05 
                 14240/1925 
                 0.483 
                 0.491 
                 1.03 
                 0.33 
                 1.02 (0.96-1.08) 
                 0.49 
               
               
                   
                 C08 
                 14242/1925 
                 0.623 
                 0.625 
                 1.01 
                 0.83 
                 1.01 (0.95-1.08) 
                 0.72 
               
               
                   
                 C15 
                 14237/1925 
                 0.058 
                 0.059 
                 1.02 
                 0.78 
                 1.00 (0.88-1.14) 
                 0.96 
               
               
                   
                 C16 
                 14224/1922 
                 0.637 
                 0.638 
                 1.00 
                 0.91 
                 1.00 (0.94-1.07) 
                 0.92 
               
               
                   
                 C08 
                 14241/1925 
                 0.623 
                 0.625 
                 1.01 
                 0.83 
                 1.01 (0.95-1.08) 
                 0.72 
               
               
                   
                 C21 
                 14236/1924 
                 0.230 
                 0.231 
                 1.00 
                 0.97 
                 0.97 (0.90-1.05) 
                 0.48 
               
               
                   
                 C04 
                 14242/1924 
                 0.506 
                 0.505 
                 0.99 
                 0.84 
                 1.00 (0.94-1.05) 
                 0.87 
               
               
                   
                 C17 
                 14240/1925 
                 0.310 
                 0.301 
                 0.96 
                 0.24 
                 0.99 (0.94-1.04) 
                 0.64 
               
               
                   
                 C12 
                 14235/1924 
                 0.356 
                 0.358 
                 1.01 
                 0.84 
                 1.01 (0.96-1.07) 
                 0.63 
               
               
                   
                 C05 
                 14232/1924 
                 0.301 
                 0.314 
                 1.07 
                 0.084 
                 1.01 (0.96-1.06) 
                 0.68 
               
               
                   
                 C18 
                 13709/1832 
                 0.188 
                 0.192 
                 1.03 
                 0.52 
                 1.02 (0.94-1.10) 
                 0.68 
               
               
                   
                 C13 
                 14241/1925 
                 0.176 
                 0.177 
                 1.01 
                 0.79 
                 1.02 (0.94-1.10) 
                 0.69 
               
               
                   
                 C12 
                 14234/1924 
                 0.137 
                 0.131 
                 0.95 
                 0.34 
                 0.98 (0.91-1.05) 
                 0.53 
               
               
                   
                 C05 
                 14240/1924 
                 0.317 
                 0.319 
                 1.01 
                 0.82 
                 1.02 (0.97-1.07) 
                 0.42 
               
               
                   
                 C04 
                 14229/1923 
                 0.540 
                 0.533 
                 0.97 
                 0.4 
                 1.00 (0.95-1.05) 
                 0.91 
               
               
                   
                 C05 
                 14223/1923 
                 0.484 
                 0.471 
                 0.95 
                 0.14 
                 0.98 (0.93-1.03) 
                 0.45 
               
               
                   
                 C06 
                 14224/1922 
                 0.331 
                 0.326 
                 0.98 
                 0.55 
                 0.98 (0.92-1.05) 
                 0.55 
               
               
                   
                 C10 
                 14246/1925 
                 0.650 
                 0.650 
                 1.00 
                 0.99 
                 0.99 (0.94-1.05) 
                 0.78 
               
               
                   
                 C01 
                 14237/1924 
                 0.139 
                 0.135 
                 0.97 
                 0.51 
                 0.96 (0.90-1.04) 
                 0.33 
               
               
                   
                 C02 
                 14242/1925 
                 0.498 
                 0.495 
                 0.99 
                 0.71 
                 0.98 (0.93-1.02) 
                 0.29 
               
               
                   
                 C04 
                 14230/1923 
                 0.671 
                 0.674 
                 1.02 
                 0.68 
                 1.00 (0.94-1.07) 
                 0.98 
               
               
                   
                 C02 
                 14241/1924 
                 0.762 
                 0.754 
                 0.96 
                 0.29 
                 0.99 (0.93-1.05) 
                 0.71 
               
               
                   
                 C06 
                 14219/1921 
                 0.628 
                 0.628 
                 1.00 
                 0.99 
                 0.99 (0.93-1.05) 
                 0.67 
               
               
                   
                 C10 
                 14240/1925 
                 0.373 
                 0.390 
                 1.08 
                 0.035 
                 1.00 (0.95-1.05) 
                 0.98 
               
               
                   
                 C17 
                 14222/1922 
                 0.260 
                 0.250 
                 0.95 
                 0.2 
                 0.98 (0.93-1.04) 
                 0.53 
               
               
                   
                 C12 
                 14239/1924 
                 0.897 
                 0.898 
                 1.01 
                 0.88 
                 1.00 (0.91-1.09) 
                 0.96 
               
               
                   
                 C01 
                 14219/1921 
                 0.399 
                 0.392 
                 0.97 
                 0.38 
                 0.96 (0.91-1.02) 
                 0.2 
               
               
                   
                 C18 
                 14226/1922 
                 0.597 
                 0.599 
                 1.01 
                 0.81 
                 1.01 (0.96-1.06) 
                 0.65 
               
               
                   
                 C06 
                 14219/1922 
                 0.624 
                 0.620 
                 0.98 
                 0.64 
                 0.97 (0.91-1.04) 
                 0.42 
               
               
                   
                 C08 
                 14233/1923 
                 0.871 
                 0.868 
                 0.98 
                 0.68 
                 0.98 (0.90-1.08) 
                 0.69 
               
               
                   
                 C14 
                 14231/1923 
                 0.923 
                 0.923 
                 1.00 
                 0.97 
                 0.99 (0.88-1.12) 
                 0.91 
               
               
                   
                 C10 
                 14217/1921 
                 0.450 
                 0.441 
                 0.96 
                 0.26 
                 0.99 (0.93-1.05) 
                 0.68 
               
               
                   
                 C01 
                 14244/1925 
                 0.041 
                 0.040 
                 0.96 
                 0.66 
                 0.94 (0.80-1.10) 
                 0.45 
               
               
                   
                 C03 
                 14223/1921 
                 0.670 
                 0.669 
                 0.99 
                 0.84 
                 1.01 (0.96-1.07) 
                 0.72 
               
               
                   
                 C05 
                 14236/1924 
                 0.649 
                 0.647 
                 0.99 
                 0.82 
                 0.97 (0.92-1.02) 
                 0.24 
               
               
                   
                 C14 
                 14234/1923 
                 0.274 
                 0.268 
                 0.97 
                 0.41 
                 0.96 (0.90-1.03) 
                 0.29 
               
               
                   
                 C10 
                 14241/1925 
                 0.377 
                 0.380 
                 1.01 
                 0.73 
                 1.01 (0.94-1.07) 
                 0.84 
               
               
                   
                 C08 
                 14236/1924 
                 0.533 
                 0.536 
                 1.01 
                 0.74 
                 1.04 (0.98-1.09) 
                 0.19 
               
               
                   
                 C10 
                 14241/1924 
                 0.780 
                 0.772 
                 0.95 
                 0.23 
                 0.95 (0.89-1.01) 
                 0.095 
               
               
                   
                 C12 
                 14238/1924 
                 0.111 
                 0.104 
                 0.92 
                 0.14 
                 0.93 (0.85-1.02) 
                 0.11 
               
               
                   
                 C06 
                 14229/1923 
                 0.365 
                 0.362 
                 0.99 
                 0.73 
                 1.00 (0.93-1.06) 
                 0.91 
               
               
                   
                 C02 
                 14233/1924 
                 0.900 
                 0.896 
                 0.96 
                 0.47 
                 0.95 (0.87-1.04) 
                 0.24 
               
               
                   
                 C10 
                 14239/1924 
                 0.085 
                 0.081 
                 0.95 
                 0.42 
                 0.93 (0.85-1.03) 
                 0.19 
               
               
                   
                 C13 
                 14222/1922 
                 0.510 
                 0.510 
                 1.00 
                 0.95 
                 0.98 (0.93-1.04) 
                 0.49 
               
               
                   
                 C10 
                 14241/1923 
                 0.857 
                 0.845 
                 0.91 
                 0.05 
                 0.93 (0.87-1.00) 
                 0.036 
               
               
                   
                 C14 
                 14238/1923 
                 0.473 
                 0.482 
                 1.03 
                 0.32 
                 1.03 (0.98-1.09) 
                 0.19 
               
               
                   
                 C02 
                 14171/1913 
                 0.233 
                 0.222 
                 0.94 
                 0.14 
                 0.95 (0.89-1.03) 
                 0.21 
               
               
                   
                 C08 
                 14221/1922 
                 0.556 
                 0.550 
                 0.97 
                 0.44 
                 0.94 (0.90-0.99) 
                 0.024 
               
               
                   
                 C12 
                 14240/1925 
                 0.836 
                 0.829 
                 0.95 
                 0.3 
                 0.95 (0.89-1.02) 
                 0.17 
               
               
                   
                 C14 
                 14232/1923 
                 0.537 
                 0.536 
                 0.99 
                 0.86 
                 0.97 (0.92-1.02) 
                 0.18 
               
               
                   
                 C02 
                 14215/1922 
                 0.731 
                 0.717 
                 0.93 
                 0.061 
                 0.95 (0.90-1.01) 
                 0.089 
               
               
                   
                 C08 
                 14240/1926 
                 0.328 
                 0.315 
                 0.94 
                 0.11 
                 0.97 (0.92-1.02) 
                 0.21 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                 Table 4G - MI 
                 Iceland (28321/2395) 
                 Combined (47717/7577) 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Chr 
                 SNP 
                 Pos_B36 
                 Allele 
                 nc/na 
                 Ctr. fr 
                 Aff. fr 
                 OR 
                 P 
                 OR (95% CI) 
                 P 
               
               
                   
               
               
                 C06 
                 rs11751605 
                 160883220 
                 C 
                 28085/2387 
                 0.111 
                 0.128 
                 1.18 
                 0.00098 
                 1.16 (1.10-1.22) 
                 1.11E−07 
               
               
                 C10 
                 rs2243547 
                 91000459 
                 G 
                 28033/2386 
                 0.331 
                 0.363 
                 1.15 
                 2.71E−05 
                 1.11 (1.06-1.16) 
                 1.81E−05 
               
               
                 C10 
                 rs1412444 
                 90992907 
                 A 
                 28293/2394 
                 0.361 
                 0.389 
                 1.13 
                 0.00037 
                 1.11 (1.06-1.17) 
                 3.30E−05 
               
               
                 C01 
                 rs12134779 
                 63168930 
                 T 
                 28320/2394 
                 0.292 
                 0.325 
                 1.17 
                 9.41E−06 
                 1.09 (1.04-1.14) 
                 8.32E−05 
               
               
                 C11 
                 rs2163612 
                 82856844 
                 G 
                 28294/2393 
                 0.479 
                 0.519 
                 1.17 
                 1.01E−06 
                 1.08 (1.04-1.13) 
                 0.00011 
               
               
                 C05 
                 rs254850 
                 158599309 
                 T 
                 28316/2395 
                 0.220 
                 0.242 
                 1.13 
                 0.0011 
                 1.11 (1.05-1.18) 
                 0.00013 
               
               
                 C17 
                 rs9902941 
                 17674485 
                 C 
                 28319/2395 
                 0.347 
                 0.384 
                 1.17 
                 2.90E−06 
                 1.08 (1.04-1.13) 
                 0.00023 
               
               
                 C20 
                 rs6076623 
                 4084671 
                 T 
                 28302/2395 
                 0.367 
                 0.399 
                 1.15 
                 4.51E−05 
                 1.08 (1.03-1.12) 
                 0.0004 
               
               
                 C05 
                 rs4921437 
                 158623529 
                 T 
                 28259/2386 
                 0.216 
                 0.240 
                 1.14 
                 0.00049 
                 1.10 (1.04-1.15) 
                 0.00041 
               
               
                 C05 
                 rs832540 
                 56234959 
                 C 
                 28307/2395 
                 0.422 
                 0.444 
                 1.09 
                 0.0061 
                 1.08 (1.03-1.12) 
                 0.00063 
               
               
                 C19 
                 rs12459084 
                 17031885 
                 T 
                 27962/2387 
                 0.350 
                 0.380 
                 1.14 
                 0.00013 
                 1.10 (1.04-1.17) 
                 0.00071 
               
               
                 C07 
                 rs1029396 
                 116812056 
                 G 
                 28315/2395 
                 0.071 
                 0.084 
                 1.21 
                 0.0018 
                 1.13 (1.05-1.21) 
                 0.00076 
               
               
                 C17 
                 rs6502622 
                 17775416 
                 G 
                 28303/2395 
                 0.358 
                 0.393 
                 1.16 
                 6.50E−06 
                 1.07 (1.03-1.11) 
                 0.00078 
               
               
                 C17 
                 rs854787 
                 17975744 
                 C 
                 28104/2381 
                 0.400 
                 0.432 
                 1.14 
                 4.64E−05 
                 1.07 (1.03-1.11) 
                 0.0008 
               
               
                 C14 
                 rs7158073 
                 99211442 
                 T 
                 28102/2379 
                 0.430 
                 0.458 
                 1.12 
                 0.0005 
                 1.09 (1.04-1.14) 
                 0.00083 
               
               
                 C10 
                 rs2243548 
                 91000293 
                 A 
                 28294/2392 
                 0.512 
                 0.540 
                 1.12 
                 0.0007 
                 1.08 (1.03-1.13) 
                 0.0009 
               
               
                 C17 
                 rs4925119 
                 17683629 
                 A 
                 28218/2387 
                 0.345 
                 0.380 
                 1.16 
                 7.74E−06 
                 1.07 (1.03-1.11) 
                 0.0011 
               
               
                 C17 
                 rs3183702 
                 17688014 
                 T 
                 28108/2388 
                 0.348 
                 0.384 
                 1.17 
                 4.13E−06 
                 1.07 (1.03-1.11) 
                 0.0012 
               
               
                 C17 
                 rs854813 
                 17944570 
                 C 
                 28182/2393 
                 0.385 
                 0.420 
                 1.16 
                 1.06E−05 
                 1.07 (1.03-1.11) 
                 0.0013 
               
               
                 C05 
                 rs953861 
                 158705160 
                 G 
                 28318/2395 
                 0.161 
                 0.180 
                 1.14 
                 0.0027 
                 1.10 (1.04-1.17) 
                 0.0014 
               
               
                 C07 
                 rs12534186 
                 117079572 
                 T 
                 28310/2394 
                 0.081 
                 0.096 
                 1.22 
                 0.00056 
                 1.13 (1.05-1.22) 
                 0.0017 
               
               
                 C12 
                 rs2417821 
                 20081535 
                 T 
                 28317/2395 
                 0.754 
                 0.771 
                 1.10 
                 0.014 
                 1.07 (1.03-1.13) 
                 0.0023 
               
               
                 C20 
                 rs1741318 
                 4105600 
                 A 
                 28315/2394 
                 0.450 
                 0.474 
                 1.10 
                 0.0025 
                 1.07 (1.03-1.12) 
                 0.0024 
               
               
                 C06 
                 rs2074464 
                 29516507 
                 T 
                 28296/2392 
                 0.446 
                 0.471 
                 1.11 
                 0.0015 
                 1.06 (1.02-1.10) 
                 0.0031 
               
               
                 C07 
                 rs324594 
                 136305863 
                 C 
                 28310/2395 
                 0.266 
                 0.289 
                 1.12 
                 0.0023 
                 1.08 (1.03-1.14) 
                 0.0033 
               
               
                 C05 
                 rs270654 
                 158497687 
                 G 
                 28318/2395 
                 0.137 
                 0.151 
                 1.12 
                 0.012 
                 1.11 (1.03-1.18) 
                 0.0036 
               
               
                 C15 
                 rs4779984 
                 30302218 
                 G 
                 28236/2392 
                 0.100 
                 0.116 
                 1.18 
                 0.0015 
                 1.12 (1.04-1.21) 
                 0.0038 
               
               
                 C05 
                 rs7709212 
                 158696755 
                 T 
                 28305/2394 
                 0.680 
                 0.702 
                 1.11 
                 0.004 
                 1.07 (1.02-1.13) 
                 0.0039 
               
               
                 C05 
                 rs10045431 
                 158747111 
                 A 
                 28238/2364 
                 0.266 
                 0.285 
                 1.10 
                 0.011 
                 1.08 (1.02-1.13) 
                 0.0039 
               
               
                 C17 
                 rs2955355 
                 17889200 
                 C 
                 28312/2395 
                 0.285 
                 0.321 
                 1.19 
                 8.68E−07 
                 1.06 (1.02-1.11) 
                 0.005 
               
               
                 C11 
                 rs7944761 
                 1361414 
                 T 
                 28309/2395 
                 0.532 
                 0.555 
                 1.09 
                 0.0053 
                 1.07 (1.02-1.12) 
                 0.0057 
               
               
                 C05 
                 rs4704400 
                 76586766 
                 T 
                 28306/2394 
                 0.498 
                 0.520 
                 1.09 
                 0.0057 
                 1.06 (1.02-1.11) 
                 0.006 
               
               
                 C17 
                 rs4925114 
                 17651995 
                 A 
                 28266/2391 
                 0.357 
                 0.389 
                 1.15 
                 4.55E−05 
                 1.06 (1.02-1.11) 
                 0.006 
               
               
                 C05 
                 rs1433048 
                 158688423 
                 G 
                 27899/2344 
                 0.193 
                 0.211 
                 1.11 
                 0.0074 
                 1.08 (1.02-1.15) 
                 0.0069 
               
               
                 C05 
                 rs7447732 
                 158461713 
                 C 
                 28280/2393 
                 0.320 
                 0.343 
                 1.11 
                 0.0033 
                 1.06 (1.01-1.10) 
                 0.0098 
               
               
                 C02 
                 rs2244871 
                 128115310 
                 C 
                 28251/2394 
                 0.413 
                 0.433 
                 1.08 
                 0.013 
                 1.06 (1.01-1.10) 
                 0.011 
               
               
                 C01 
                 rs2946534 
                 18647370 
                 T 
                 28302/2394 
                 0.571 
                 0.599 
                 1.12 
                 0.00034 
                 1.06 (1.01-1.11) 
                 0.012 
               
               
                 C04 
                 rs7661204 
                 45728007 
                 T 
                 28320/2395 
                 0.449 
                 0.427 
                 0.91 
                 0.0055 
                 0.95 (0.91-0.99) 
                 0.012 
               
               
                 C05 
                 rs6556861 
                 94554256 
                 G 
                 28317/2395 
                 0.570 
                 0.591 
                 1.09 
                 0.0082 
                 1.06 (1.01-1.10) 
                 0.012 
               
               
                 C06 
                 rs7753765 
                 71732495 
                 A 
                 28312/2395 
                 0.144 
                 0.166 
                 1.18 
                 0.00014 
                 1.08 (1.01-1.14) 
                 0.014 
               
               
                 C05 
                 rs870347 
                 6898035 
                 T 
                 28313/2395 
                 0.926 
                 0.937 
                 1.20 
                 0.0052 
                 1.12 (1.02-1.24) 
                 0.015 
               
               
                 C10 
                 rs12269612 
                 15475877 
                 T 
                 28314/2395 
                 0.401 
                 0.423 
                 1.09 
                 0.0078 
                 1.05 (1.01-1.10) 
                 0.015 
               
               
                 C15 
                 rs2110209 
                 24946433 
                 A 
                 28318/2395 
                 0.048 
                 0.061 
                 1.28 
                 0.00051 
                 1.12 (1.02-1.23) 
                 0.018 
               
               
                 C02 
                 rs12329252 
                 212093968 
                 T 
                 28321/2395 
                 0.681 
                 0.703 
                 1.10 
                 0.0047 
                 1.05 (1.01-1.09) 
                 0.019 
               
               
                 C14 
                 rs8003722 
                 68388015 
                 A 
                 28317/2394 
                 0.106 
                 0.119 
                 1.14 
                 0.0085 
                 1.07 (1.01-1.14) 
                 0.019 
               
               
                 C21 
                 rs2828495 
                 24038081 
                 A 
                 28316/2395 
                 0.212 
                 0.234 
                 1.14 
                 0.001 
                 1.07 (1.01-1.12) 
                 0.021 
               
               
                 C05 
                 rs270661 
                 158492732 
                 A 
                 28319/2394 
                 0.210 
                 0.227 
                 1.10 
                 0.011 
                 1.06 (1.01-1.12) 
                 0.022 
               
               
                 C08 
                 rs334198 
                 18933089 
                 C 
                 28309/2393 
                 0.922 
                 0.913 
                 0.89 
                 0.037 
                 0.91 (0.84-0.99) 
                 0.022 
               
               
                 C01 
                 rs2476601 
                 114179091 
                 A 
                 28313/2395 
                 0.129 
                 0.152 
                 1.21 
                 3.14E−05 
                 1.07 (1.01-1.14) 
                 0.024 
               
               
                 C13 
                 rs4769613 
                 28036609 
                 T 
                 28313/2394 
                 0.465 
                 0.494 
                 1.12 
                 0.00041 
                 1.05 (1.01-1.09) 
                 0.024 
               
               
                 C08 
                 rs3102526 
                 96858538 
                 G 
                 27995/2382 
                 0.647 
                 0.666 
                 1.09 
                 0.013 
                 1.05 (1.01-1.10) 
                 0.029 
               
               
                 C08 
                 rs3134517 
                 96859237 
                 G 
                 28308/2395 
                 0.647 
                 0.666 
                 1.09 
                 0.016 
                 1.05 (1.00-1.10) 
                 0.032 
               
               
                 C01 
                 rs3748744 
                 19828833 
                 G 
                 28280/2394 
                 0.898 
                 0.907 
                 1.11 
                 0.063 
                 1.09 (1.01-1.17) 
                 0.034 
               
               
                 C04 
                 rs4282162 
                 21426819 
                 T 
                 28305/2395 
                 0.530 
                 0.555 
                 1.11 
                 0.002 
                 1.05 (1.00-1.09) 
                 0.036 
               
               
                 C16 
                 rs8050136 
                 52373776 
                 A 
                 28316/2394 
                 0.404 
                 0.426 
                 1.10 
                 0.0046 
                 1.05 (1.00-1.09) 
                 0.039 
               
               
                 C16 
                 rs3751812 
                 52375961 
                 T 
                 28246/2392 
                 0.403 
                 0.426 
                 1.10 
                 0.0041 
                 1.05 (1.00-1.09) 
                 0.039 
               
               
                 C17 
                 rs854793 
                 17971249 
                 A 
                 28313/2395 
                 0.202 
                 0.229 
                 1.18 
                 3.33E−05 
                 1.05 (1.00-1.10) 
                 0.041 
               
               
                 C10 
                 rs4880711 
                 5217871 
                 C 
                 27953/2379 
                 0.351 
                 0.367 
                 1.07 
                 0.042 
                 1.05 (1.00-1.10) 
                 0.043 
               
               
                 C12 
                 rs12304836 
                 124654446 
                 C 
                 28205/2385 
                 0.143 
                 0.163 
                 1.17 
                 0.00054 
                 1.06 (1.00-1.12) 
                 0.043 
               
               
                 C05 
                 rs38055 
                 52596401 
                 T 
                 28311/2395 
                 0.387 
                 0.403 
                 1.07 
                 0.052 
                 1.04 (1.00-1.08) 
                 0.053 
               
               
                 C09 
                 rs2297538 
                 138684489 
                 G 
                 28226/2395 
                 0.730 
                 0.753 
                 1.13 
                 0.0012 
                 1.06 (1.00-1.13) 
                 0.053 
               
               
                 C16 
                 rs1870843 
                 81316815 
                 T 
                 28313/2395 
                 0.602 
                 0.623 
                 1.09 
                 0.0081 
                 1.05 (1.00-1.10) 
                 0.064 
               
               
                 C06 
                 rs6905466 
                 19958854 
                 T 
                 28315/2395 
                 0.332 
                 0.355 
                 1.11 
                 0.0027 
                 1.04 (1.00-1.10) 
                 0.074 
               
               
                 C12 
                 rs11045689 
                 21092930 
                 G 
                 28210/2386 
                 0.301 
                 0.319 
                 1.09 
                 0.017 
                 1.04 (1.00-1.08) 
                 0.083 
               
               
                 C13 
                 rs1887263 
                 22381716 
                 A 
                 28175/2393 
                 0.204 
                 0.216 
                 1.08 
                 0.067 
                 1.05 (0.99-1.11) 
                 0.089 
               
               
                 C18 
                 rs4271662 
                 26051291 
                 C 
                 28256/2390 
                 0.587 
                 0.602 
                 1.06 
                 0.061 
                 1.03 (0.99-1.07) 
                 0.11 
               
               
                 C18 
                 rs1365254 
                 70238283 
                 T 
                 28319/2395 
                 0.196 
                 0.208 
                 1.08 
                 0.066 
                 1.05 (0.99-1.11) 
                 0.11 
               
               
                 C06 
                 rs3016536 
                 162157939 
                 G 
                 28320/2395 
                 0.519 
                 0.538 
                 1.08 
                 0.02 
                 1.04 (0.99-1.08) 
                 0.12 
               
               
                 C12 
                 rs3742049 
                 119438873 
                 C 
                 28300/2394 
                 0.919 
                 0.928 
                 1.14 
                 0.029 
                 1.06 (0.98-1.14) 
                 0.13 
               
               
                 C03 
                 rs9874646 
                 62437858 
                 T 
                 28314/2394 
                 0.717 
                 0.729 
                 1.06 
                 0.11 
                 1.03 (0.99-1.08) 
                 0.17 
               
               
                 C14 
                 rs2281519 
                 93846385 
                 T 
                 28281/2395 
                 0.260 
                 0.282 
                 1.12 
                 0.0023 
                 1.04 (0.98-1.09) 
                 0.17 
               
               
                 C02 
                 rs6747236 
                 35901725 
                 T 
                 28311/2395 
                 0.717 
                 0.739 
                 1.12 
                 0.0021 
                 1.03 (0.98-1.08) 
                 0.18 
               
               
                 C04 
                 rs6534683 
                 129601758 
                 T 
                 28310/2395 
                 0.656 
                 0.670 
                 1.06 
                 0.076 
                 1.03 (0.99-1.08) 
                 0.18 
               
               
                 C01 
                 rs2991515 
                 57656898 
                 T 
                 28319/2395 
                 0.483 
                 0.507 
                 1.10 
                 0.0033 
                 1.03 (0.99-1.07) 
                 0.19 
               
               
                 C04 
                 rs4697653 
                 10337857 
                 G 
                 28161/2392 
                 0.524 
                 0.549 
                 1.11 
                 0.0021 
                 1.03 (0.99-1.07) 
                 0.19 
               
               
                 C06 
                 rs9380681 
                 37638433 
                 C 
                 28318/2395 
                 0.311 
                 0.327 
                 1.08 
                 0.038 
                 1.03 (0.98-1.08) 
                 0.19 
               
               
                 C10 
                 rs11199158 
                 85297471 
                 G 
                 28319/2395 
                 0.618 
                 0.635 
                 1.08 
                 0.024 
                 1.03 (0.99-1.08) 
                 0.19 
               
               
                 C13 
                 rs1375719 
                 102208783 
                 C 
                 28316/2394 
                 0.499 
                 0.517 
                 1.07 
                 0.032 
                 1.03 (0.99-1.08) 
                 0.19 
               
               
                 C08 
                 rs3931282 
                 129179963 
                 T 
                 28319/2395 
                 0.568 
                 0.543 
                 0.90 
                 0.0016 
                 0.97 (0.93-1.02) 
                 0.21 
               
               
                 C14 
                 rs17776453 
                 100774793 
                 G 
                 28313/2394 
                 0.955 
                 0.961 
                 1.15 
                 0.095 
                 1.06 (0.96-1.17) 
                 0.24 
               
               
                 C01 
                 rs12724604 
                 20948045 
                 A 
                 28248/2386 
                 0.037 
                 0.045 
                 1.23 
                 0.0098 
                 1.07 (0.95-1.20) 
                 0.25 
               
               
                 C05 
                 rs950195 
                 97466690 
                 G 
                 28228/2395 
                 0.633 
                 0.656 
                 1.10 
                 0.0033 
                 1.03 (0.98-1.07) 
                 0.25 
               
               
                 C05 
                 rs728676 
                 118087433 
                 T 
                 28310/2394 
                 0.444 
                 0.468 
                 1.10 
                 0.0023 
                 1.02 (0.98-1.07) 
                 0.25 
               
               
                 C06 
                 rs7739802 
                 162154323 
                 T 
                 28266/2393 
                 0.493 
                 0.511 
                 1.07 
                 0.027 
                 1.03 (0.98-1.08) 
                 0.26 
               
               
                 C10 
                 rs7086224 
                 30857283 
                 A 
                 28287/2393 
                 0.419 
                 0.437 
                 1.08 
                 0.028 
                 1.03 (0.98-1.07) 
                 0.27 
               
               
                 C01 
                 rs4845552 
                 151746622 
                 G 
                 28269/2393 
                 0.128 
                 0.145 
                 1.15 
                 0.0025 
                 1.03 (0.97-1.09) 
                 0.3 
               
               
                 C08 
                 rs10504537 
                 73402234 
                 A 
                 28213/2387 
                 0.881 
                 0.891 
                 1.11 
                 0.035 
                 1.04 (0.97-1.11) 
                 0.32 
               
               
                 C02 
                 rs1395930 
                 123468570 
                 T 
                 28303/2393 
                 0.499 
                 0.523 
                 1.10 
                 0.0032 
                 1.02 (0.98-1.06) 
                 0.33 
               
               
                 C02 
                 rs3943703 
                 127613790 
                 C 
                 28280/2395 
                 0.214 
                 0.229 
                 1.09 
                 0.02 
                 1.02 (0.97-1.08) 
                 0.44 
               
               
                 C10 
                 rs2279434 
                 45275070 
                 T 
                 28318/2395 
                 0.067 
                 0.080 
                 1.20 
                 0.0029 
                 1.03 (0.95-1.12) 
                 0.46 
               
               
                 C10 
                 rs11198993 
                 85244450 
                 A 
                 28239/2387 
                 0.697 
                 0.714 
                 1.08 
                 0.022 
                 1.02 (0.97-1.07) 
                 0.46 
               
               
                 C10 
                 rs7921473 
                 85156395 
                 G 
                 28314/2395 
                 0.820 
                 0.840 
                 1.15 
                 0.0011 
                 1.02 (0.96-1.08) 
                 0.51 
               
               
                 C12 
                 rs1465026 
                 65789635 
                 G 
                 28309/2395 
                 0.837 
                 0.852 
                 1.12 
                 0.011 
                 1.02 (0.96-1.08) 
                 0.52 
               
               
                 C12 
                 rs1568383 
                 88017285 
                 T 
                 28316/2395 
                 0.098 
                 0.111 
                 1.15 
                 0.008 
                 1.02 (0.95-1.09) 
                 0.55 
               
               
                 C08 
                 rs4732849 
                 28249765 
                 T 
                 28321/2395 
                 0.275 
                 0.295 
                 1.10 
                 0.0069 
                 1.01 (0.97-1.06) 
                 0.56 
               
               
                 C08 
                 rs7006687 
                 18277862 
                 T 
                 28306/2392 
                 0.579 
                 0.604 
                 1.11 
                 0.0018 
                 1.01 (0.97-1.05) 
                 0.73 
               
               
                 C02 
                 rs921083 
                 176453128 
                 G 
                 28310/2394 
                 0.781 
                 0.798 
                 1.11 
                 0.0092 
                 1.01 (0.96-1.06) 
                 0.78 
               
               
                 C02 
                 rs6709904 
                 43933828 
                 A 
                 28315/2395 
                 0.909 
                 0.918 
                 1.12 
                 0.058 
                 1.01 (0.94-1.08) 
                 0.84 
               
               
                 C14 
                 rs1957860 
                 53499105 
                 T 
                 28313/2395 
                 0.448 
                 0.439 
                 0.96 
                 0.27 
                 1.00 (0.96-1.04) 
                 0.86 
               
               
                 C14 
                 rs4444235 
                 53480669 
                 T 
                 28305/2394 
                 0.536 
                 0.543 
                 1.03 
                 0.37 
                 1.00 (0.96-1.04) 
                 0.88 
               
               
                   
               
            
           
           
               
               
            
               
                 Table 4H - CAD 
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Pos in 
                   
                 Iceland (28321/3047) 
                 Combined (47717/9155) 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Chr 
                 SNP 
                 Build 36 
                 Allele 
                 nc/na 
                 Ctr. fr 
                 Aff. fr 
                 OR 
                 P 
                 OR (95% CI) 
                 P 
               
               
                   
               
               
                 C06 
                 rs11751605 
                 160883220 
                 C 
                 28085/3033 
                 0.111 
                 0.128 
                 1.17 
                 0.00039 
                 1.16 (1.10-1.22) 
                 1.16E−08 
               
               
                 C20 
                 rs6076623 
                 4084671 
                 T 
                 28302/3047 
                 0.367 
                 0.400 
                 1.15 
                 3.56E−06 
                 1.08 (1.04-1.13) 
                 0.0000292 
               
               
                 C10 
                 rs1412444 
                 90992907 
                 A 
                 28293/3045 
                 0.361 
                 0.383 
                 1.10 
                 0.0014 
                 1.10 (1.05-1.15) 
                 5.21E−05 
               
               
                 C11 
                 rs2163612 
                 82856844 
                 G 
                 28294/3045 
                 0.479 
                 0.513 
                 1.15 
                 3.61E−06 
                 1.08 (1.04-1.12) 
                 0.0000533 
               
               
                 C07 
                 rs1029396 
                 116812056 
                 G 
                 28315/3047 
                 0.071 
                 0.086 
                 1.24 
                 0.0000612 
                 1.14 (1.07-1.22) 
                 0.0000824 
               
               
                 C10 
                 rs2243547 
                 91000459 
                 G 
                 28033/3033 
                 0.331 
                 0.355 
                 1.11 
                 6.60E−04 
                 1.09 (1.04-1.14) 
                 1.10E−04 
               
               
                 C07 
                 rs12534186 
                 117079572 
                 T 
                 28310/3046 
                 0.081 
                 0.098 
                 1.24 
                 0.0000302 
                 1.15 (1.07-1.23) 
                 0.00021 
               
               
                 C01 
                 rs12134779 
                 63168930 
                 T 
                 28320/3046 
                 0.292 
                 0.316 
                 1.12 
                 2.80E−04 
                 1.07 (1.03-1.12) 
                 3.70E−04 
               
               
                 C14 
                 rs7158073 
                 99211442 
                 T 
                 28102/3027 
                 0.430 
                 0.453 
                 1.10 
                 0.0016 
                 1.08 (1.03-1.13) 
                 0.00076 
               
               
                 C05 
                 rs254850 
                 158599309 
                 T 
                 28316/3047 
                 0.220 
                 0.236 
                 1.10 
                 0.0082 
                 1.09 (1.04-1.15) 
                 0.00095 
               
               
                 C12 
                 rs2417821 
                 20081535 
                 T 
                 28317/3047 
                 0.754 
                 0.772 
                 1.10 
                 0.0042 
                 1.08 (1.03-1.12) 
                 0.001 
               
               
                 C04 
                 rs7661204 
                 45728007 
                 T 
                 28320/3047 
                 0.449 
                 0.425 
                 0.91 
                 0.00074 
                 0.94 (0.90-0.97) 
                 0.0011 
               
               
                 C05 
                 rs4921437 
                 158623529 
                 T 
                 28259/3037 
                 0.216 
                 0.235 
                 1.11 
                 0.0022 
                 1.08 (1.03-1.13) 
                 0.0011 
               
               
                 C05 
                 rs832540 
                 56234959 
                 C 
                 28307/3047 
                 0.422 
                 0.443 
                 1.09 
                 0.0043 
                 1.07 (1.03-1.11) 
                 0.0012 
               
               
                 C07 
                 rs324594 
                 136305863 
                 C 
                 28310/3047 
                 0.266 
                 0.287 
                 1.11 
                 0.0018 
                 1.08 (1.03-1.13) 
                 0.0014 
               
               
                 C20 
                 rs1741318 
                 4105600 
                 A 
                 28315/3046 
                 0.450 
                 0.473 
                 1.10 
                 0.0013 
                 1.07 (1.03-1.12) 
                 0.0019 
               
               
                 C17 
                 rs9902941 
                 17674485 
                 C 
                 28319/3047 
                 0.347 
                 0.371 
                 1.11 
                 9.50E−04 
                 1.06 (1.02-1.10) 
                 0.0028 
               
               
                 C05 
                 rs7709212 
                 158696755 
                 T 
                 28305/3046 
                 0.680 
                 0.699 
                 1.09 
                 0.0061 
                 1.07 (1.02-1.12) 
                 0.0029 
               
               
                 C01 
                 rs2946534 
                 18647370 
                 T 
                 28302/3046 
                 0.571 
                 0.596 
                 1.11 
                 0.00045 
                 1.07 (1.02-1.11) 
                 0.0032 
               
               
                 C05 
                 rs6556861 
                 94554256 
                 G 
                 28317/3047 
                 0.570 
                 0.590 
                 1.08 
                 0.006 
                 1.06 (1.02-1.10) 
                 0.0034 
               
               
                 C16 
                 rs8050136 
                 52373776 
                 A 
                 28316/3046 
                 0.404 
                 0.430 
                 1.11 
                 0.00029 
                 1.06 (1.02-1.10) 
                 0.0038 
               
               
                 C16 
                 rs3751812 
                 52375961 
                 T 
                 28246/3044 
                 0.403 
                 0.430 
                 1.12 
                 0.00024 
                 1.06 (1.02-1.10) 
                 0.004 
               
               
                 C13 
                 rs4769613 
                 28036609 
                 T 
                 28313/3046 
                 0.465 
                 0.493 
                 1.12 
                 0.00013 
                 1.05 (1.02-1.10) 
                 0.0059 
               
               
                 C10 
                 rs2243548 
                 91000293 
                 A 
                 28294/3043 
                 0.512 
                 0.532 
                 1.08 
                 0.0087 
                 1.06 (1.02-1.11) 
                 0.0064 
               
               
                 C19 
                 rs12459084 
                 17031885 
                 T 
                 27962/3037 
                 0.350 
                 0.372 
                 1.10 
                 0.002 
                 1.07 (1.02-1.13) 
                 0.0067 
               
               
                 C06 
                 rs2074464 
                 29516507 
                 T 
                 28296/3044 
                 0.446 
                 0.466 
                 1.08 
                 0.006 
                 1.05 (1.01-1.09) 
                 0.0076 
               
               
                 C02 
                 rs2244871 
                 128115310 
                 C 
                 28251/3046 
                 0.413 
                 0.430 
                 1.08 
                 0.015 
                 1.05 (1.01-1.10) 
                 0.0079 
               
               
                 C05 
                 rs270654 
                 158497687 
                 G 
                 28318/3047 
                 0.137 
                 0.149 
                 1.10 
                 0.021 
                 1.09 (1.02-1.16) 
                 0.0092 
               
               
                 C17 
                 rs854787 
                 17975744 
                 C 
                 28104/3028 
                 0.400 
                 0.420 
                 1.09 
                 4.60E−03 
                 1.05 (1.01-1.09) 
                 0.0097 
               
               
                 C11 
                 rs7944761 
                 1361414 
                 T 
                 28309/3047 
                 0.532 
                 0.554 
                 1.09 
                 0.0027 
                 1.06 (1.01-1.10) 
                 0.011 
               
               
                 C15 
                 rs4779984 
                 30302218 
                 G 
                 28236/3043 
                 0.100 
                 0.114 
                 1.15 
                 0.003 
                 1.10 (1.02-1.18) 
                 0.011 
               
               
                 C17 
                 rs6502622 
                 17775416 
                 G 
                 28303/3047 
                 0.358 
                 0.380 
                 1.10 
                 1.90E−03 
                 1.05 (1.01-1.09) 
                 0.013 
               
               
                 C17 
                 rs3183702 
                 17688014 
                 T 
                 28108/3038 
                 0.348 
                 0.371 
                 1.10 
                 1.30E−03 
                 1.05 (1.01-1.09) 
                 0.014 
               
               
                 C05 
                 rs1433048 
                 158688423 
                 G 
                 27899/2989 
                 0.193 
                 0.207 
                 1.09 
                 0.021 
                 1.07 (1.01-1.13) 
                 0.015 
               
               
                 C17 
                 rs4925119 
                 17683629 
                 A 
                 28218/3036 
                 0.345 
                 0.367 
                 1.10 
                 2.10E−03 
                 1.05 (1.01-1.09) 
                 0.015 
               
               
                 C01 
                 rs2476601 
                 114179091 
                 A 
                 28313/3047 
                 0.129 
                 0.148 
                 1.18 
                 9.72E−05 
                 1.07 (1.01-1.14) 
                 0.016 
               
               
                 C05 
                 rs870347 
                 6898035 
                 T 
                 28313/3047 
                 0.926 
                 0.936 
                 1.17 
                 0.0088 
                 1.11 (1.02-1.21) 
                 0.017 
               
               
                 C08 
                 rs334198 
                 18933089 
                 C 
                 28309/3045 
                 0.922 
                 0.915 
                 0.91 
                 0.082 
                 0.92 (0.85-0.98) 
                 0.018 
               
               
                 C17 
                 rs854813 
                 17944570 
                 C 
                 28182/3042 
                 0.385 
                 0.406 
                 1.09 
                 3.10E−03 
                 1.05 (1.01-1.09) 
                 0.018 
               
               
                 C06 
                 rs7753765 
                 71732495 
                 A 
                 28312/3047 
                 0.144 
                 0.165 
                 1.18 
                 0.0000474 
                 1.07 (1.01-1.13) 
                 0.02 
               
               
                 C17 
                 rs4925114 
                 17651995 
                 A 
                 28266/3042 
                 0.357 
                 0.379 
                 1.10 
                 1.70E−03 
                 1.05 (1.01-1.09) 
                 0.02 
               
               
                 C05 
                 rs270661 
                 158492732 
                 A 
                 28319/3046 
                 0.210 
                 0.223 
                 1.08 
                 0.025 
                 1.06 (1.01-1.11) 
                 0.022 
               
               
                 C05 
                 rs953861 
                 158705160 
                 G 
                 28318/3047 
                 0.161 
                 0.172 
                 1.08 
                 0.052 
                 1.07 (1.01-1.13) 
                 0.022 
               
               
                 C05 
                 rs10045431 
                 158747111 
                 A 
                 28238/3014 
                 0.266 
                 0.277 
                 1.06 
                 0.095 
                 1.06 (1.01-1.11) 
                 0.022 
               
               
                 C14 
                 rs8003722 
                 68388015 
                 A 
                 28317/3046 
                 0.106 
                 0.116 
                 1.11 
                 0.024 
                 1.07 (1.01-1.13) 
                 0.024 
               
               
                 C09 
                 rs2297538 
                 138684489 
                 G 
                 28226/3047 
                 0.730 
                 0.752 
                 1.12 
                 0.00079 
                 1.06 (1.01-1.12) 
                 0.027 
               
               
                 C02 
                 rs12329252 
                 212093968 
                 T 
                 28321/3047 
                 0.681 
                 0.700 
                 1.09 
                 0.0059 
                 1.04 (1.00-1.08) 
                 0.029 
               
               
                 C01 
                 rs3748744 
                 19828833 
                 G 
                 28280/3046 
                 0.898 
                 0.908 
                 1.11 
                 0.033 
                 1.08 (1.01-1.16) 
                 0.031 
               
               
                 C05 
                 rs4704400 
                 76586766 
                 T 
                 28306/3046 
                 0.498 
                 0.514 
                 1.07 
                 0.023 
                 1.04 (1.00-1.09) 
                 0.036 
               
               
                 C08 
                 rs3102526 
                 96858538 
                 G 
                 27995/3019 
                 0.647 
                 0.664 
                 1.08 
                 0.015 
                 1.05 (1.00-1.09) 
                 0.046 
               
               
                 C15 
                 rs2110209 
                 24946433 
                 A 
                 28318/3047 
                 0.048 
                 0.057 
                 1.19 
                 0.0061 
                 1.10 (1.00-1.20) 
                 0.048 
               
               
                 C16 
                 rs1870843 
                 81316815 
                 T 
                 28313/3047 
                 0.602 
                 0.621 
                 1.08 
                 0.0098 
                 1.04 (1.00-1.09) 
                 0.048 
               
               
                 C08 
                 rs3134517 
                 96859237 
                 G 
                 28308/3047 
                 0.647 
                 0.664 
                 1.08 
                 0.018 
                 1.05 (1.00-1.09) 
                 0.049 
               
               
                 C21 
                 rs2828495 
                 24038081 
                 A 
                 28316/3047 
                 0.212 
                 0.232 
                 1.12 
                 0.00089 
                 1.05 (1.00-1.11) 
                 0.051 
               
               
                 C04 
                 rs4282162 
                 21426819 
                 T 
                 28305/3047 
                 0.530 
                 0.552 
                 1.09 
                 0.0031 
                 1.04 (1.00-1.08) 
                 0.052 
               
               
                 C17 
                 rs2955355 
                 17889200 
                 C 
                 28312/3047 
                 0.285 
                 0.309 
                 1.12 
                 3.30E−04 
                 1.04 (1.00-1.08) 
                 0.052 
               
               
                 C12 
                 rs11045689 
                 21092930 
                 G 
                 28210/3037 
                 0.301 
                 0.317 
                 1.08 
                 0.015 
                 1.04 (1.00-1.08) 
                 0.054 
               
               
                 C05 
                 rs7447732 
                 158461713 
                 C 
                 28280/3045 
                 0.320 
                 0.337 
                 1.08 
                 0.015 
                 1.04 (1.00-1.08) 
                 0.064 
               
               
                 C18 
                 rs1365254 
                 70238283 
                 T 
                 28319/3047 
                 0.196 
                 0.209 
                 1.08 
                 0.036 
                 1.05 (1.00-1.11) 
                 0.065 
               
               
                 C13 
                 rs1887263 
                 22381716 
                 A 
                 28175/3042 
                 0.204 
                 0.217 
                 1.08 
                 0.037 
                 1.05 (1.00-1.11) 
                 0.066 
               
               
                 C12 
                 rs12304836 
                 124654446 
                 C 
                 28205/3034 
                 0.143 
                 0.160 
                 1.14 
                 0.00095 
                 1.05 (0.99-1.11) 
                 0.084 
               
               
                 C05 
                 rs38055 
                 52596401 
                 T 
                 28311/3047 
                 0.387 
                 0.399 
                 1.05 
                 0.091 
                 1.03 (0.99-1.07) 
                 0.091 
               
               
                 C04 
                 rs4697653 
                 10337857 
                 G 
                 28161/3040 
                 0.524 
                 0.543 
                 1.08 
                 0.0081 
                 1.03 (0.99-1.07) 
                 0.1 
               
               
                 C05 
                 rs728676 
                 118087433 
                 T 
                 28310/3046 
                 0.444 
                 0.468 
                 1.10 
                 0.001 
                 1.03 (0.99-1.07) 
                 0.1 
               
               
                 C06 
                 rs6905466 
                 19958854 
                 T 
                 28315/3047 
                 0.332 
                 0.351 
                 1.09 
                 0.0058 
                 1.04 (0.99-1.09) 
                 0.1 
               
               
                 C10 
                 rs11199158 
                 85297471 
                 G 
                 28319/3047 
                 0.618 
                 0.637 
                 1.09 
                 0.0062 
                 1.03 (0.99-1.08) 
                 0.1 
               
               
                 C01 
                 rs4845552 
                 151746622 
                 G 
                 28269/3044 
                 0.128 
                 0.146 
                 1.16 
                 0.00041 
                 1.05 (0.99-1.11) 
                 0.11 
               
               
                 C02 
                 rs1395930 
                 123468570 
                 T 
                 28303/3045 
                 0.499 
                 0.528 
                 1.12 
                 0.00012 
                 1.03 (0.99-1.07) 
                 0.12 
               
               
                 C04 
                 rs6534683 
                 129601758 
                 T 
                 28310/3047 
                 0.656 
                 0.671 
                 1.07 
                 0.034 
                 1.04 (0.99-1.08) 
                 0.12 
               
               
                 C02 
                 rs6747236 
                 35901725 
                 T 
                 28311/3047 
                 0.717 
                 0.734 
                 1.09 
                 0.0098 
                 1.03 (0.99-1.08) 
                 0.13 
               
               
                 C06 
                 rs3016536 
                 162157939 
                 G 
                 28320/3047 
                 0.519 
                 0.537 
                 1.08 
                 0.013 
                 1.03 (0.99-1.08) 
                 0.13 
               
               
                 C10 
                 rs12269612 
                 15475877 
                 T 
                 28314/3047 
                 0.401 
                 0.418 
                 1.07 
                 0.024 
                 1.03 (0.99-1.07) 
                 0.13 
               
               
                 C17 
                 rs854793 
                 17971249 
                 A 
                 28313/3047 
                 0.202 
                 0.220 
                 1.12 
                 1.80E−03 
                 1.03 (0.99-1.08) 
                 0.14 
               
               
                 C12 
                 rs3742049 
                 119438873 
                 C 
                 28300/3046 
                 0.919 
                 0.928 
                 1.13 
                 0.023 
                 1.05 (0.98-1.13) 
                 0.15 
               
               
                 C01 
                 rs2991515 
                 57656898 
                 T 
                 28319/3047 
                 0.483 
                 0.508 
                 1.10 
                 0.00077 
                 1.03 (0.99-1.07) 
                 0.16 
               
               
                 C18 
                 rs4271662 
                 26051291 
                 C 
                 28256/3039 
                 0.587 
                 0.599 
                 1.05 
                 0.092 
                 1.03 (0.99-1.06) 
                 0.16 
               
               
                 C06 
                 rs7739802 
                 162154323 
                 T 
                 28266/3043 
                 0.493 
                 0.512 
                 1.08 
                 0.011 
                 1.03 (0.99-1.07) 
                 0.18 
               
               
                 C08 
                 rs10504537 
                 73402234 
                 A 
                 28213/3035 
                 0.881 
                 0.891 
                 1.11 
                 0.027 
                 1.04 (0.98-1.11) 
                 0.2 
               
               
                 C14 
                 rs17776453 
                 100774793 
                 G 
                 28313/3045 
                 0.955 
                 0.962 
                 1.17 
                 0.033 
                 1.06 (0.97-1.16) 
                 0.21 
               
               
                 C10 
                 rs7086224 
                 30857283 
                 A 
                 28287/3045 
                 0.419 
                 0.434 
                 1.06 
                 0.04 
                 1.03 (0.98-1.07) 
                 0.22 
               
               
                 C01 
                 rs12724604 
                 20948045 
                 A 
                 28248/3037 
                 0.037 
                 0.043 
                 1.19 
                 0.021 
                 1.07 (0.96-1.19) 
                 0.23 
               
               
                 C03 
                 rs9874646 
                 62437858 
                 T 
                 28314/3046 
                 0.717 
                 0.726 
                 1.05 
                 0.16 
                 1.02 (0.98-1.07) 
                 0.24 
               
               
                 C05 
                 rs950195 
                 97466690 
                 G 
                 28228/3046 
                 0.633 
                 0.654 
                 1.10 
                 0.002 
                 1.02 (0.98-1.07) 
                 0.25 
               
               
                 C14 
                 rs2281519 
                 93846385 
                 T 
                 28281/3045 
                 0.260 
                 0.276 
                 1.08 
                 0.014 
                 1.03 (0.98-1.08) 
                 0.27 
               
               
                 C10 
                 rs4880711 
                 5217871 
                 C 
                 27953/3015 
                 0.351 
                 0.359 
                 1.04 
                 0.26 
                 1.02 (0.98-1.07) 
                 0.34 
               
               
                 C08 
                 rs3931282 
                 129179963 
                 T 
                 28319/3047 
                 0.568 
                 0.548 
                 0.92 
                 0.007 
                 0.98 (0.94-1.02) 
                 0.39 
               
               
                 C10 
                 rs11198993 
                 85244450 
                 A 
                 28239/3038 
                 0.697 
                 0.717 
                 1.10 
                 0.0037 
                 1.02 (0.97-1.06) 
                 0.43 
               
               
                 C12 
                 rs1568383 
                 88017285 
                 T 
                 28316/3045 
                 0.098 
                 0.110 
                 1.14 
                 0.0049 
                 1.03 (0.96-1.09) 
                 0.45 
               
               
                 C06 
                 rs9380681 
                 37638433 
                 C 
                 28318/3047 
                 0.311 
                 0.319 
                 1.04 
                 0.25 
                 1.02 (0.97-1.06) 
                 0.46 
               
               
                 C02 
                 rs6709904 
                 43933828 
                 A 
                 28315/3046 
                 0.909 
                 0.919 
                 1.14 
                 0.014 
                 1.03 (0.96-1.10) 
                 0.47 
               
               
                 C10 
                 rs2279434 
                 45275070 
                 T 
                 28318/3047 
                 0.067 
                 0.076 
                 1.15 
                 0.014 
                 1.03 (0.95-1.11) 
                 0.49 
               
               
                 C13 
                 rs1375719 
                 102208783 
                 C 
                 28316/3046 
                 0.499 
                 0.511 
                 1.05 
                 0.12 
                 1.01 (0.97-1.06) 
                 0.53 
               
               
                 C10 
                 rs7921473 
                 85156395 
                 G 
                 28314/3047 
                 0.820 
                 0.838 
                 1.13 
                 0.0013 
                 1.02 (0.96-1.07) 
                 0.55 
               
               
                 C14 
                 rs1957860 
                 53499105 
                 T 
                 28313/3047 
                 0.448 
                 0.444 
                 0.98 
                 0.55 
                 1.01 (0.97-1.05) 
                 0.55 
               
               
                 C02 
                 rs3943703 
                 127613790 
                 C 
                 28280/3046 
                 0.214 
                 0.225 
                 1.07 
                 0.06 
                 1.01 (0.96-1.07) 
                 0.6 
               
               
                 C08 
                 rs7006687 
                 18277862 
                 T 
                 28306/3044 
                 0.579 
                 0.604 
                 1.11 
                 0.00068 
                 1.01 (0.97-1.05) 
                 0.6 
               
               
                 C12 
                 rs1465026 
                 65789635 
                 G 
                 28309/3047 
                 0.837 
                 0.849 
                 1.10 
                 0.024 
                 1.01 (0.96-1.06) 
                 0.67 
               
               
                 C14 
                 rs4444235 
                 53480669 
                 T 
                 28305/3046 
                 0.536 
                 0.543 
                 1.03 
                 0.32 
                 0.99 (0.96-1.03) 
                 0.7 
               
               
                 C02 
                 rs921083 
                 176453128 
                 G 
                 28310/3044 
                 0.781 
                 0.794 
                 1.08 
                 0.04 
                 1.00 (0.96-1.05) 
                 0.98 
               
               
                 C08 
                 rs4732849 
                 28249765 
                 T 
                 28321/3047 
                 0.275 
                 0.285 
                 1.05 
                 0.13 
                 1.00 (0.96-1.04) 
                 0.99 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 Surrogate markers for marker rs11751605. The markers were 
               
               
                 selected from the Caucasian data set of the HapMap sample (CEU; 
               
               
                 see http://www.hapmap.org), using a cutoff of r 2  of 0.2. The search 
               
               
                 was done in a 2Mb interval flanking the rs11751605 marker. 
               
               
                 The table shows (1) chromosome; (2) SNP rs name; (3) position in 
               
               
                 NCBI build 36; (4) value for D′ to rs11751605; (5) value for r 2  to 
               
               
                 rs11751605; (6) P-value of the association with rs11751605. 
               
               
                 Surrogates of rs11751605 based on HapMap CEU v22 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                 Pos in 
                   
                   
                   
               
               
                 Chr 
                 SNP 
                 Build 36 
                 D′ 
                 R2 
                 P 
               
               
                   
               
               
                 C06 
                 rs3798156 
                 160596206 
                 0.55 
                 0.22 
                 5.8E−05 
               
               
                 C06 
                 rs3127573 
                 160601383 
                 0.80 
                 0.43 
                 4.9E−08 
               
               
                 C06 
                 rs3127572 
                 160602208 
                 0.71 
                 0.36 
                 4.7E−07 
               
               
                 C06 
                 rs3119309 
                 160605062 
                 0.80 
                 0.44 
                 2.4E−08 
               
               
                 C06 
                 rs7756836 
                 160609247 
                 0.80 
                 0.44 
                 2.4E−08 
               
               
                 C06 
                 rs7757336 
                 160609548 
                 0.56 
                 0.29 
                 3.6E−06 
               
               
                 C06 
                 rs3119310 
                 160612365 
                 0.80 
                 0.44 
                 2.4E−08 
               
               
                 C06 
                 rs3119311 
                 160613097 
                 0.80 
                 0.44 
                 2.4E−08 
               
               
                 C06 
                 rs3127578 
                 160618145 
                 0.80 
                 0.44 
                 2.4E−08 
               
               
                 C06 
                 rs3127586 
                 160624902 
                 0.85 
                 0.67 
                 9.9E−13 
               
               
                 C06 
                 rs12206585 
                 160633514 
                 0.92 
                 0.72 
                 1.1E−13 
               
               
                 C06 
                 rs12203303 
                 160633686 
                 0.83 
                 0.55 
                 4.6E−09 
               
               
                 C06 
                 rs2183470 
                 160635083 
                 0.85 
                 0.68 
                 1.5E−13 
               
               
                 C06 
                 rs3120151 
                 160637462 
                 0.85 
                 0.68 
                 1.5E−13 
               
               
                 C06 
                 rs3103350 
                 160642995 
                 0.85 
                 0.68 
                 1.5E−13 
               
               
                 C06 
                 rs3127583 
                 160647121 
                 0.85 
                 0.68 
                 1.5E−13 
               
               
                 C06 
                 rs3106172 
                 160647965 
                 0.85 
                 0.64 
                 1.2E−10 
               
               
                 C06 
                 rs3106170 
                 160649914 
                 0.86 
                 0.72 
                 6.6E−13 
               
               
                 C06 
                 rs3125057 
                 160651662 
                 0.84 
                 0.60 
                 2.7E−11 
               
               
                 C06 
                 rs3125056 
                 160655271 
                 0.87 
                 0.45 
                 4.8E−06 
               
               
                 C06 
                 rs3125055 
                 160656777 
                 0.86 
                 0.37 
                 2.2E−06 
               
               
                 C06 
                 rs3106167 
                 160657380 
                 0.85 
                 0.68 
                 1.5E−13 
               
               
                 C06 
                 rs3127591 
                 160657792 
                 0.92 
                 0.71 
                 3.2E−12 
               
               
                 C06 
                 rs3125052 
                 160658363 
                 0.85 
                 0.68 
                 1.5E−13 
               
               
                 C06 
                 rs3120140 
                 160658821 
                 0.90 
                 0.58 
                 1.1E−08 
               
               
                 C06 
                 rs3103349 
                 160660711 
                 0.85 
                 0.68 
                 1.5E−13 
               
               
                 C06 
                 rs3125050 
                 160660826 
                 0.85 
                 0.68 
                 1.5E−13 
               
               
                 C06 
                 rs3120139 
                 160661612 
                 0.85 
                 0.68 
                 1.5E−13 
               
               
                 C06 
                 rs3125049 
                 160674702 
                 0.86 
                 0.74 
                 4.0E−15 
               
               
                 C06 
                 rs12209517 
                 160676726 
                 0.72 
                 0.46 
                 2.4E−07 
               
               
                 C06 
                 rs3120137 
                 160691182 
                 0.93 
                 0.87 
                 1.2E−17 
               
               
                 C06 
                 rs3127574 
                 160711360 
                 1.00 
                 0.20 
                 3.1E−08 
               
               
                 C06 
                 rs6905958 
                 160717615 
                 1.00 
                 0.20 
                 3.1E−08 
               
               
                 C06 
                 rs3123633 
                 160719595 
                 1.00 
                 0.20 
                 3.1E−08 
               
               
                 C06 
                 rs3123634 
                 160722229 
                 1.00 
                 0.20 
                 3.1E−08 
               
               
                 C06 
                 rs1317652 
                 160727151 
                 1.00 
                 0.20 
                 2.9E−08 
               
               
                 C06 
                 rs884742 
                 160727422 
                 1.00 
                 0.20 
                 3.1E−08 
               
               
                 C06 
                 rs7740824 
                 160728891 
                 0.91 
                 0.45 
                 1.1E−09 
               
               
                 C06 
                 rs3105748 
                 160730710 
                 1.00 
                 0.20 
                 3.1E−08 
               
               
                 C06 
                 rs3105749 
                 160740968 
                 1.00 
                 0.20 
                 3.1E−08 
               
               
                 C06 
                 rs3105752 
                 160742915 
                 1.00 
                 0.20 
                 2.9E−08 
               
               
                 C06 
                 rs10945670 
                 160747660 
                 1.00 
                 0.20 
                 3.1E−08 
               
               
                 C06 
                 rs10806731 
                 160747825 
                 1.00 
                 0.20 
                 3.1E−08 
               
               
                 C06 
                 rs9364554 
                 160753654 
                 0.92 
                 0.46 
                 5.2E−11 
               
               
                 C06 
                 rs12194182 
                 160754505 
                 0.92 
                 0.46 
                 5.2E−11 
               
               
                 C06 
                 rs3106166 
                 160758351 
                 1.00 
                 0.22 
                 2.2E−08 
               
               
                 C06 
                 rs10455782 
                 160759340 
                 1.00 
                 0.39 
                 4.6E−12 
               
               
                 C06 
                 rs7758229 
                 160760242 
                 1.00 
                 0.38 
                 2.2E−11 
               
               
                 C06 
                 rs3123636 
                 160762527 
                 1.00 
                 0.37 
                 1.9E−11 
               
               
                 C06 
                 rs3106164 
                 160770263 
                 1.00 
                 0.37 
                 6.9E−10 
               
               
                 C06 
                 rs388170 
                 160773276 
                 1.00 
                 0.36 
                 1.0E−11 
               
               
                 C06 
                 rs9365164 
                 160776833 
                 0.91 
                 0.33 
                 3.9E−08 
               
               
                 C06 
                 rs2292334 
                 160778178 
                 1.00 
                 0.33 
                 2.8E−10 
               
               
                 C06 
                 rs2048327 
                 160783522 
                 1.00 
                 0.33 
                 4.5E−11 
               
               
                 C06 
                 rs7769879 
                 160785635 
                 1.00 
                 0.33 
                 4.5E−11 
               
               
                 C06 
                 rs3918285 
                 160788644 
                 1.00 
                 0.33 
                 4.5E−11 
               
               
                 C06 
                 rs3918286 
                 160788658 
                 1.00 
                 0.33 
                 1.1E−10 
               
               
                 C06 
                 rs1810126 
                 160792141 
                 1.00 
                 0.34 
                 3.0E−11 
               
               
                 C06 
                 rs3088442 
                 160792642 
                 1.00 
                 0.33 
                 4.5E−11 
               
               
                 C06 
                 rs2063347 
                 160802019 
                 1.00 
                 0.33 
                 4.5E−11 
               
               
                 C06 
                 rs3106162 
                 160803284 
                 1.00 
                 0.33 
                 4.5E−11 
               
               
                 C06 
                 rs2063346 
                 160804265 
                 1.00 
                 0.34 
                 3.5E−11 
               
               
                 C06 
                 rs1112073 
                 160810832 
                 1.00 
                 0.38 
                 8.0E−12 
               
               
                 C06 
                 rs3127602 
                 160812231 
                 1.00 
                 0.37 
                 8.9E−12 
               
               
                 C06 
                 rs3123629 
                 160826076 
                 1.00 
                 0.37 
                 7.6E−12 
               
               
                 C06 
                 rs3127599 
                 160827124 
                 1.00 
                 0.37 
                 7.6E−12 
               
               
                 C06 
                 rs3127569 
                 160837549 
                 1.00 
                 0.39 
                 4.0E−12 
               
               
                 C06 
                 rs3127596 
                 160873025 
                 1.00 
                 0.38 
                 4.7E−12 
               
               
                 C06 
                 rs3124785 
                 160874495 
                 1.00 
                 0.38 
                 7.6E−12 
               
               
                 C06 
                 rs11751605 
                 160883220 
                 1.00 
                 1.00 
                 0.0E+00 
               
               
                 C06 
                 rs10455872 
                 160930108 
                 1.00 
                 0.55 
                 1.3E−11 
               
               
                 C06 
                 rs2315065 
                 161028134 
                 0.66 
                 0.35 
                 4.6E−07 
               
               
                 C06 
                 rs9458266 
                 161798149 
                 0.58 
                 0.22 
                 1.7E−04 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 Key to the sequence listing provided herein. 
               
            
           
           
               
               
            
               
                 Seq ID No: 
                 SNP 
               
               
                   
               
            
           
           
               
               
            
               
                 1 
                 rs11751605 
               
               
                 2 
                 rs6076623 
               
               
                 3 
                 rs1412444 
               
               
                 4 
                 rs2163612 
               
               
                 5 
                 rs1029396 
               
               
                 6 
                 rs2243547 
               
               
                 7 
                 rs12534186 
               
               
                 8 
                 rs12134779 
               
               
                 9 
                 rs7158073 
               
               
                 10 
                 rs254850 
               
               
                 11 
                 rs2417821 
               
               
                 12 
                 rs7661204 
               
               
                 13 
                 rs4921437 
               
               
                 14 
                 rs832540 
               
               
                 15 
                 rs324594 
               
               
                 16 
                 rs1741318 
               
               
                 17 
                 rs9902941 
               
               
                 18 
                 rs7709212 
               
               
                 19 
                 rs2946534 
               
               
                 20 
                 rs6556861 
               
               
                 21 
                 rs8050136 
               
               
                 22 
                 rs3751812 
               
               
                 23 
                 rs4769613 
               
               
                 24 
                 rs2243548 
               
               
                 25 
                 rs12459084 
               
               
                 26 
                 rs2074464 
               
               
                 27 
                 rs2244871 
               
               
                 28 
                 rs270654 
               
               
                 29 
                 rs854787 
               
               
                 30 
                 rs7944761 
               
               
                 31 
                 rs4779984 
               
               
                 32 
                 rs6502622 
               
               
                 33 
                 rs3183702 
               
               
                 34 
                 rs1433048 
               
               
                 35 
                 rs4925119 
               
               
                 36 
                 rs2476601 
               
               
                 37 
                 rs870347 
               
               
                 38 
                 rs334198 
               
               
                 39 
                 rs854813 
               
               
                 40 
                 rs7753765 
               
               
                 41 
                 rs4925114 
               
               
                 42 
                 rs270661 
               
               
                 43 
                 rs953861 
               
               
                 44 
                 rs10045431 
               
               
                 45 
                 rs8003722 
               
               
                 46 
                 rs2297538 
               
               
                 47 
                 rs12329252 
               
               
                 48 
                 rs3748744 
               
               
                 49 
                 rs4704400 
               
               
                 50 
                 rs3102526 
               
               
                 51 
                 rs2110209 
               
               
                 52 
                 rs1870843 
               
               
                 53 
                 rs3134517 
               
               
                 54 
                 rs2828495 
               
               
                 55 
                 rs4282162 
               
               
                 56 
                 rs2955355 
               
               
                 57 
                 rs11045689 
               
               
                 58 
                 rs7447732 
               
               
                 59 
                 rs1365254 
               
               
                 60 
                 rs1887263 
               
               
                 61 
                 rs12304836 
               
               
                 62 
                 rs38055 
               
               
                 63 
                 rs4697653 
               
               
                 64 
                 rs728676 
               
               
                 65 
                 rs6905466 
               
               
                 66 
                 rs11199158 
               
               
                 67 
                 rs4845552 
               
               
                 68 
                 rs1395930 
               
               
                 69 
                 rs6534683 
               
               
                 70 
                 rs6747236 
               
               
                 71 
                 rs3016536 
               
               
                 72 
                 rs12269612 
               
               
                 73 
                 rs854793 
               
               
                 74 
                 rs3742049 
               
               
                 75 
                 rs2991515 
               
               
                 76 
                 rs4271662 
               
               
                 77 
                 rs7739802 
               
               
                 78 
                 rs10504537 
               
               
                 79 
                 rs17776453 
               
               
                 80 
                 rs7086224 
               
               
                 81 
                 rs12724604 
               
               
                 82 
                 rs9874646 
               
               
                 83 
                 rs950195 
               
               
                 84 
                 rs2281519 
               
               
                 85 
                 rs4880711 
               
               
                 86 
                 rs3931282 
               
               
                 87 
                 rs11198993 
               
               
                 88 
                 rs1568383 
               
               
                 89 
                 rs9380681 
               
               
                 90 
                 rs6709904 
               
               
                 91 
                 rs2279434 
               
               
                 92 
                 rs1375719 
               
               
                 93 
                 rs7921473 
               
               
                 94 
                 rs1957860 
               
               
                 95 
                 rs3943703 
               
               
                 96 
                 rs7006687 
               
               
                 97 
                 rs1465026 
               
               
                 98 
                 rs4444235 
               
               
                 99 
                 rs921083 
               
               
                 100 
                 rs4732849 
               
               
                 101 
                 rs3798156 
               
               
                 102 
                 rs3127573 
               
               
                 103 
                 rs3127572 
               
               
                 104 
                 rs3119309 
               
               
                 105 
                 rs7756836 
               
               
                 106 
                 rs7757336 
               
               
                 107 
                 rs3119310 
               
               
                 108 
                 rs3119311 
               
               
                 109 
                 rs3127578 
               
               
                 110 
                 rs3127586 
               
               
                 111 
                 rs12206585 
               
               
                 112 
                 rs12203303 
               
               
                 113 
                 rs2183470 
               
               
                 114 
                 rs3120151 
               
               
                 115 
                 rs3103350 
               
               
                 116 
                 rs3127583 
               
               
                 117 
                 rs3106172 
               
               
                 118 
                 rs3106170 
               
               
                 119 
                 rs3125057 
               
               
                 120 
                 rs3125056 
               
               
                 121 
                 rs3125055 
               
               
                 122 
                 rs3106167 
               
               
                 123 
                 rs3127591 
               
               
                 124 
                 rs3125052 
               
               
                 125 
                 rs3120140 
               
               
                 126 
                 rs3103349 
               
               
                 127 
                 rs3125050 
               
               
                 128 
                 rs3120139 
               
               
                 129 
                 rs3125049 
               
               
                 130 
                 rs12209517 
               
               
                 131 
                 rs3120137 
               
               
                 132 
                 rs3127574 
               
               
                 133 
                 rs6905958 
               
               
                 134 
                 rs3123633 
               
               
                 135 
                 rs3123634 
               
               
                 136 
                 rs1317652 
               
               
                 137 
                 rs884742 
               
               
                 138 
                 rs7740824 
               
               
                 139 
                 rs3105748 
               
               
                 140 
                 rs3105749 
               
               
                 141 
                 rs3105752 
               
               
                 142 
                 rs10945670 
               
               
                 143 
                 rs10806731 
               
               
                 144 
                 rs9364554 
               
               
                 145 
                 rs12194182 
               
               
                 146 
                 rs3106166 
               
               
                 147 
                 rs10455782 
               
               
                 148 
                 rs7758229 
               
               
                 149 
                 rs3123636 
               
               
                 150 
                 rs3106164 
               
               
                 151 
                 rs388170 
               
               
                 152 
                 rs9365164 
               
               
                 153 
                 rs2292334 
               
               
                 154 
                 rs2048327 
               
               
                 155 
                 rs7769879 
               
               
                 156 
                 rs3918285 
               
               
                 157 
                 rs3918286 
               
               
                 158 
                 rs1810126 
               
               
                 159 
                 rs3088442 
               
               
                 160 
                 rs2063347 
               
               
                 161 
                 rs3106162 
               
               
                 162 
                 rs2063346 
               
               
                 163 
                 rs1112073 
               
               
                 164 
                 rs3127602 
               
               
                 165 
                 rs3123629 
               
               
                 166 
                 rs3127599 
               
               
                 167 
                 rs3127569 
               
               
                 168 
                 rs3127596 
               
               
                 169 
                 rs3124785 
               
               
                 170 
                 rs10455872 
               
               
                 171 
                 rs2315065 
               
               
                 172 
                 rs9458266