Patent Publication Number: US-4546105-A

Title: Pyrrolylaminopiperidines, compositions thereof and methods of use

Description:
To the best of our knowledge the compounds of the present invention have not heretofore been described or suggested. 
     The compounds of the present invention have the general formula ##STR3## where R is hydrogen, loweralkyl, Arloweralkyl, cycloalkylloweralkyl, loweralkanoyl and thienylloweralkyl; R 1  is hydrogen, loweralkyl, loweralkylcarbonyl, loweralkoxycarbonyl, loweralkylthiocarbonyl ##STR4## cyano, loweralkylaminocarbonyl, diloweralkylaminocarbonyl, cycloalkylcarbonyl, cycloalkylloweralkylcarbonyl and loweralkenylcarbonyl; R 2  is hydrogen, halogen and --CH 3  ; and the pharmaceutically acceptable salts thereof. 
     Particularly preferred compounds of the invention are those of Compound I where R is phenylethyl; R 1  is loweralkoxycarbonyl, loweralkylcarbonyl and cyano; and R 2  is hydrogen. 
     In the above definitions and as used hereinafter, the term &#34;lower&#34; means the group it is describing contains 1 to 6 carbon atoms. The term &#34;alkyl&#34; refers to a straight or branched chain hydrocarbon containing no unsaturation, e.g. methyl, ethyl, propyl, tertiary-butyl, isopropyl, etc. The term &#34;Arloweralkyl&#34; refers to a monovalent substituent which consists of an aryl group, e.g. phenyl, p-nitrophenyl, o-toluyl, m-methoxyphenyl, etc., linked through a lower alkylene group having its free valence bond from a carbon of the lower alkylene group and having a formula of ##STR5## where Z is hydrogen, halogen, CF 3 , NO 2 , NH 2 , loweralkyl, and loweralkoxy. The term &#34;alkylene&#34; refers to a bivalent radical of the lower branched or unbranched alkyl group it is derived from having valence bonds from two terminal carbons thereof, e.g., ethylene (--CH 2  CH 2  --), propylene (--CH 2  CH 2  CH 2  --), isopropylene ##STR6## etc. The term &#34;alkoxy&#34; refers to a monovalent substituent which consists of an alkyl group linked through an ether oxygen having its free valence bond from the ether oxygen, e.g. methoxy, ethoxy, isopropoxy, butoxy, etc. The term &#34;halogen&#34; refers to a member of the family consisting of fluorine, chlorine, bromine and iodine. The term &#34;cycloalkylloweralkyl&#34; refers to a monovalent substituent consisting of a saturated hydrocarbon group possessing at least one carbocyclic ring of 3 to 7 carbon atoms, e.g. cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, etc., linked through a lower alkyl group. The term &#34;alkenyl&#34; refers to a straight or branched chain hydrocarbon containing one unsaturated or double bond, e.g. CH 2  ═CH--, ##STR7## etc. The term &#34;thienylloweralkyl&#34; means ##STR8## 
     The compounds of the present invention are prepared in the following manner. The substituents R, R 1  and R 2  are as defined above unless indicated otherwise. 
     A substituted 1-aminopyrrole of the formula ##STR9## is selected. Compound II is typically prepared in the manner described in Flitsch et al., Chem. Ber. 102, 3268-3276 (1969) which describes the preparation of 1-aminopyrrole and substituted 1-aminopyrroles. 
     Compound II is condensed with Compound III having the formula ##STR10## by heating at 80° to 120° C. for 2 to 24 hours in the presence of an inert solvent, e.g. benzene, toluene, cyclohexane, etc., followed by reduction with an agent such as sodium borohydride in a solvent such as isopropanol at 60°-80° to form a condensation product of the invention having the formula ##STR11## 
     Compound IV is reacted under conventional substitution reaction conditions, typically in the presence of a polar solvent, e.g. dimethylformamide, dichloromethane, chloroform, etc. a base, such as for example K 2  CO 3 , Na 2  CO 3 , NaHCO 3 , etc., at a temperature of 25° to 60° C. for 2 to 24 hours, with an acid halide having the formula ##STR12## where Hal is a halogen and R 3  is loweralkyl of 1 to 5 carbon atoms [(C 1  -C 5 )-alkyl], cycloalkyl and loweralkenyl of 1 to 5 carbon atoms [(C 1  -C 5 )-alkenyl] to form a compound of the invention having a formula ##STR13## The carbonyl group of compound V in turn can be reduced in a conventional manner, e.g. with borane-tetrahydrofuran complex at a temperature of -30° C. to 0° C. for a time of 1 minute to 60 minutes, with zinc amalgam in hydrochloric acid, hydrogen in the presence of a catalyst, such as Pd, etc., to provide Compound I, where R 1  is loweralkyl of 1 to 6 carbon atoms, when R 3  is (C 1  -C 5 ) alkyl or (C 1  -C 5 ) alkenyl; or to provide Compound I where R 1  is loweralkylcycloalkyl when R 3  is cycloalkyl. Compound V, where R 3  is (C 1  -C 5 ) alkyl, is reacted in the manner reported in Bull. Soc. Chim. Belg. 87, (3), 229-238 (1978) with p-methoxyphenylthionophosphine sulfide dimer to form a compound of the invention having the formula ##STR14## 
     Compound IV is reacted under conventional substitution reaction conditions with a halocyanide of the formula Hal-CN, where Hal is a halogen, e.g. Br, to form a compound of the invention having the formula ##STR15## Typically the reaction is carried out in a polar solvent, e.g. dimethylformamide, chloroform, dichloromethane, etc. at a temperature of 25° to 60° C. for 2 to 24 hours. 
     Compound IV is reacted, under conventional substitution reaction conditions, in a polar solvent at 25° to 60° C. for 2 to 24 hours with a haloformate ester of the formula ##STR16## where Hal is a halogen and R 4  is a (C 1  -C 6 ) alkyl to form a compound of the invention having the formula ##STR17## 
     Compound IV is reacted with an isocyanate compound of the formula R 5  --N═C═O (X) where R 5  is (C 1  -C 6 ) alkyl to form a compound of the invention having the formula ##STR18## Typically this reaction is carried out in a nonpolar solvent, e.g. benzene, toluene, xylene, etc., at a temperature of 50° to 80° C. for 4 to 24 hours. Compound XI in turn can be further N-substituted in a conventional manner of alkylation, such as for example by treatment of the sodium salt thereof (from sodium metal or sodium hydride) with an alkyl iodide, e.g. methyliodide, or dimethylsulfate. 
     Compounds of the present invention are useful as analgesic agents due to their ability to alleviate pain in mammals. The activity of the compounds is demonstrated in the 2-phenyl-1,4-benzoquinone-induced writhing test in mice, a standard assay for analgesia [Proc. Soc. Exptl. Biol. Med. 95, 729 (1957)]. 
     The analgesic activity of some of the compounds expressed in a dosage of the compounds which exhibit either (a) a 50% effective dose inhibition (ED 50 ) or (b) a percent inhibition is given in Table I. 
     
                                           TABLE I                                 
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              (ED.sub.50)                                                 
                     (ED.sub.50)                                          
              Subcutaneous                                                
                     Oral Dose   Sub-                                     
              Dose in                                                     
                     in Mg/kg    cutaneous                                
              Mg/kg of                                                    
                     of Body                                              
                           %     Dose                                     
Compound      Body Weight                                                 
                     Weight                                               
                           (Decrease)                                     
                                 (Mg/kg)                                  
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N--[1-(2-phenethyl)                                                       
               0.35  1.4   --    --                                       
piperidin-4-yl]-                                                          
N--(1H--pyrrol-1-yl)                                                      
propanamide                                                               
hydrochloride                                                             
N--[1-(2-phenethyl)                                                       
              1.2    9.5   --    --                                       
piperidin-4-yl)]-                                                         
N--(1H--pyrrol-1-yl)-                                                     
acetamide                                                                 
hydrochloride                                                             
N--[1-(2-phenethyl)                                                       
              2.4    5.6   --    --                                       
piperidin-4-yl]-                                                          
N--(1H--pyrrol-1-yl)                                                      
carbamic acid                                                             
ethyl ester                                                               
hydrochloride                                                             
N--[1-(2-phenethyl)                                                       
               0.65  7.7   --    --                                       
piperidin-4-yl]-N--                                                       
(1H--pyrrol-1-yl)                                                         
carbamic acid methyl                                                      
ester hydrochloride                                                       
N--[1-(2-phenethyl)                                                       
              2.4    --    --    --                                       
piperidin-4-yl]-                                                          
N--(1H--pyrrol-1-yl)                                                      
cyanamide                                                                 
hydrochloride                                                             
N--{1-[2-(4-  --     --    76    40                                       
chlorophenyl)ethyl]                                                       
piperidin-4-yl}-N--                                                       
(1H--pyrrol-1-yl)                                                         
propanamide                                                               
N--[1-(n-butyl)                                                           
              --     --    20    20                                       
piperidin-4-yl]-N--                                                       
(1H--pyrrol-1-yl)                                                         
carbamic acid ethyl                                                       
ester                                                                     
N--[1-(n-butyl)                                                           
              --     --    45    10                                       
piperidin-4-yl]-                                                          
N--(1H--pyrrol-1-yl)                                                      
propanamide                                                               
maleate                                                                   
1-(2-phenethyl)-                                                          
              --     --    49    10                                       
4-(1H--pyrrol-1-yl)                                                       
aminopiperidine                                                           
maleate                                                                   
N--{1-[2-(4-methoxy-                                                      
              --     --    27    10                                       
phenyl)ethyl]piperidin-                                                   
4-yl}-N--(1H--pyrrol-1-yl)                                                
propanamide                                                               
N--{1-[2-(4-methoxy-                                                      
              --     --    51    10                                       
phenyl)ethyl]piperidin-                                                   
4-yl}-N--(1H--pyrrol-                                                     
1-yl)cyanamide                                                            
hydrochloride                                                             
1-(2-phenethyl)-4-                                                        
              --     --    53    10                                       
[N--(n-propyl)-N--(1H--                                                   
pyrrol-1-yl)]amino-                                                       
piperidine oxalate                                                        
N--[1-(2-phenyl-                                                          
              --     --    30    10                                       
propyl)-piperidin-                                                        
4-yl]-N--(1H--pyrrol-                                                     
1-yl)propanamide                                                          
hydrochloride                                                             
N--[1-(2-phenyl-                                                          
              --     --    42    10                                       
propyl)piperidin-4-                                                       
yl]-N--(1H--pyrrol-1-                                                     
yl)carbamic acid                                                          
ethyl ester                                                               
N--[1-(2-phenethyl)                                                       
              --     --    100   10                                       
piperidin-4-yl]-N--                                                       
(1H--pyrrol-1-yl)                                                         
acrylamide                                                                
hydrochloride                                                             
N--[1-(2-phenethyl)                                                       
              --     --    100   10                                       
piperidin-4-yl]-N--                                                       
(1H--pyrrol-1-yl)-N&#39;--                                                    
methylurea                                                                
hydrochloride                                                             
N--[1-(2-phenethyl)                                                       
              --     --    65    10                                       
piperidin-4-yl]-N--                                                       
(1H--pyrrol-1-yl)                                                         
cyclobutanecarboxylic                                                     
acid amide                                                                
hydrochloride                                                             
N--{1-[2-(2-thienyl)                                                      
              --     --    54    10                                       
ethyl]piperidin-4-                                                        
yl}-N--(1H--pyrrol-1-                                                     
yl)carbamic acid                                                          
ethyl ester                                                               
hydrochloride                                                             
N--[1-(2-phenethyl)                                                       
              --     --    99    10                                       
piperidin-4-yl]-                                                          
N--(1H--pyrrol-1-yl)                                                      
propanethioamide                                                          
hydrochloride                                                             
__________________________________________________________________________
 
    
     Effective amounts of the compounds of the present invention may be administered to a subject by one of various methods, for example, orally as in capsules or tablets, parenterally in the form of sterile solutions or suspensions, and in some cases intravenously in the form of sterile solutions. The compounds of the invention, while effective themselves, may be formulated and administered in the form of their pharmaceutically acceptable acid addition salts for purposes of stability, convenience of crystallization, increased solubility and the like. 
     Preferred pharmaceutically acceptable acid addition salts include those derived from inorganic acids such as hydrochloric, hydrobromic, sulfuric, nitric, phosphoric, perchloric acids and the like as well as organic acids such as tartaric, citric, succinic, maleic, fumaric acids and the like. 
     The compounds of the present invention may be administered orally, for example, with an inert diluent or with an edible carrier. They may be enclosed in gelatin capsules or compressed into tablets. For the purpose of oral therapeutic administration, the compounds may be incorporated with excipients and used in the form of tablets, troches, capsules, elixirs, suspensions, syrups, wafers, chewing gums and the like. These preparations should contain at least 4% of the pyrrolylaminopiperidines and related compounds of the invention, the active ingredient, but may be varied depending upon the particular form and may conveniently be between 4% to about 70% of the weight of the unit. The amount of the compound present in such compositions is such that a suitable dosage will be obtained. Preferred compositions and preparations according to the present invention are prepared so that an oral dosage unit form contains between 5.0-300 milligrams of the pyrrolylaminopiperidines and related compounds of the invention. 
     The tablets, pills, capsules, troches and the like may also contain the following adjuvants: a binder such as microcrystalline cellulose, gum tragacanth or gelatin; an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, corn starch and the like; a lubricant such as magnesium stearate or Sterotex; a glidant such as colloidal silicon dioxide; and a sweetening agent such as sucrose or saccharin may be added or a flavoring agent such as peppermint, methyl salicylate or orange flavoring. When the dosage unit form is a capsule, it may contain, in addition to material of the above type, a liquid carrier such as a fatty oil. Other dosage unit forms may contain other various materials which modify the physical form of the dosage unit, for example, as coatings. Thus, tablets or pills may be coated with sugar, shellac, or other enteric coating agents. A syrup may contain, in addition to the present compounds, sucrose as a sweetening agent and certain preservatives, dyes and colorings and flavors. Materials used in preparing these various compositions should be pharmaceutically pure and non-toxic in the amounts used. 
     For the purpose of parenteral therapeutic administration, the compounds of the present invention may be incorporated into a solution or suspension. These preparations should contain at least 0.1% of the pyrrolylaminopiperidines and related compounds of the invention, but may be varied to be between 0.1 and about 50% of the weight thereof. The amount of the inventive compound present in such compositions is such that a suitable dosage will be obtained. Preferred compositions and preparations according to the present invention are prepared so that a parenteral dosage unit contains between 5.0 to 100 milligrams of the pyrrolylaminopiperidine and related compounds of the invention. 
     The solutions or suspensions may also include the following adjuvants: a sterile diluent such as water for injection, saline solution, fixed oils, polyethylene glycols, glycerine, propylene glycol or other synthetic solvents; antibacterial agents such as benzyl alcohol or methyl paraben; antioxidants such as ascorbic acid or sodium bisulfite; chelating agents such as ethylene diaminetetraacetic acid, buffers such as acetates, citrates or phosphates and agents for the adjustment of tonicity such as sodium chloride or dextrose. The parenteral preparations can be enclosed in ampules, disposable syringes or multiple dose vials made of glass or plastic. 
    
    
     The following examples are for illustrative purposes and are not to be construed as limiting the invention disclosed herein. All temperatures are given in degrees centigrade unless indicated otherwise. 
     EXAMPLE 1 
     N-(1-Methylpiperidin-4-yl)-N-(1H-pyrrol-1-yl)propanamide maleate 
     A solution of 1-aminopyrrole (4.2 g, 0.05 mol) and 1-methyl-4-piperidone (6.9 g, 0.06 mol) in cyclohexane was refluxed overnight (about 16 hours) over 4 Å molecular sieves. After 3 hours, an additional 1 g of 1-methyl-4-piperidone was added. The molecular sieves were filtered off and the cyclohexane removed by evaporation under reduced pressure. The resulting oil was dissolved in isopropanol and 5 g of sodium borohydride added. The mixture was stirred at reflux for three hours, then methanol was added, the heat was removed, and stirring continued until the mixture had cooled to room temperature. The solvent was removed by evaporation under reduced pressure to give a residue to which water was added. This mixture was extracted with dichloromethane, the dichloromethane solution was dried with saturated sodium chloride solution and magnesium sulfate, and the dichloromethane evaporated in vacuo to give 7 g (78%) of 1-methyl-4-(1H-pyrrol-1-yl)aminopiperidine. To a cooled solution of 1-methyl-4-(1H-pyrrol-1-yl)aminopiperidine (5.4 g, 0.03 mol) and triethylamine (3.35 g, 0.033 mol) in CHCl 3  (100 ml) was added dropwise a solution of propionyl chloride (3.07 g, 0.033 mol) in CHCl 3  (100 ml). The reaction mixture was stirred at ice bath temperature for one hour, then at room temperature overnight (about 16 hours). The chloroform solution was washed with water, dried with saturated sodium chloride and magnesium sulfate, and the chloroform removed to give 4.8 g of an oil. The oxalate was formed by adding ethereal oxalic acid but did not crystallize. The resultant oil was basified, extracted with dichloromethane and dried to give 3.2 g of an oil. This oil was chromatographed on a high pressure liquid chromatograph (HPLC) using 11/2% diethylamine in acetonitrile. The resultant 1.5  g of free base was converted to the maleate (1.9 g) by adding ethereal maleic acid and recrystallized from absolute ethanol/ether to give 1.8 g, m.p. 146°-147° C. of N-(1-methylpiperidin-4-yl)-N-(1H-pyrrol-1-yl)propanamide maleate. The recovered starting material was reacted again with propionyl chloride (0.7 g) in CH 2  Cl 2  (20 ml) with sodium bicarbonate (1 g) at room temperature overnight. Work-up gave an oil which was dissolved in ether, and an ether solution of maleic acid added to give the maleate salt. Recrystallization from absolute ethanol/ether gave an additional 1.5 g of product of N-(1-methylpiperidin-4-yl)-N-(1H-pyrrol-1-yl)propanamide maleate, mp 146°-147° C., combined yield 3.3 g (9.39 mmole), 31.3% yield from 1-methyl-4-(1H-pyrrol-1-yl)aminopiperidine. 
     ANALYSIS: Calculated for C 13  H 21  N 3  O.C 4  H 4  O 4  : 58.09%C; 7.18%H; 11.96%N; Found: 58.29%C; 7.02%H; 12.05%N. 
     EXAMPLE 2 
     N-[1-(2-Phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)propanamide hydrochloride 
     A solution of 1-aminopyrrole (6 g, 73 mmole) and 1-(2-phenethyl)-4-piperidone (16 g, 80 mmole) in 250 ml benzene was stirred six hours at reflux. The reaction mixture was cooled, filtered and evaporated to 20 g of an oil. This oil was dissolved in 200 ml isopropanol and 50 ml methanol and stirred two hours at reflux with NaBH 4  (6 g, 0.16 mole). The reaction mixture was cooled and evaporated to a semi-solid which was stirred with water and extracted with ether. The organic extract was washed with water, saturated NaCl and was dried (anhydrous MgSO 4 ), filtered and evaporated to 20 g of an oil. This oil was purified by HPLC to give 17 g (86%) of an oil comprising 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine. To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine (4.5 g, 17 mmole) in 150 ml dichloromethane containing sodium bicarbonate (2.8 g, 33 mmoles) was added a solution of propionyl chloride (1.8 g, 10 mmole) in 10 ml dichloromethane. After stirring two days at ambient temperature, the reaction mixture was evaporated to an oil that was stirred with water and extracted with ethyl acetate. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO 4 ), filtered and evaporated to 5.4 g of an oil. This oil was converted to the hydrochloride salt by adding ethereal hydrogen chloride and recrystallized from isopropanol/methanol to give 5.1 g (84%) of N-[1-(2-phenethyl)-piperidin-4-yl]-N-(1H-pyrrol-1-yl)propanamide hydrochloride, d 270° C. 
     ANALYSIS: Calculated for C 20  H 27  N 3  O.HCl: 66.37%C; 7.80%H; 11.61%N; Found: 66.53%C; 7.80%H; 11.58%N; 
     EXAMPLE 3 
     N-[1-(2-Phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)acetamide hydrochloride 
     To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 11 (4.5 g, 17 mmole) in 200 ml dichloromethane containing sodium bicarbonate (2.8 g, 33 mmole) was added a solution of acetyl chloride (1.5 g, 19 mmole) in 20 ml dichloromethane. After stirring twenty hours at ambient temperature, the mixture was evaporated to a solid that was stirred with water and extracted with ethyl acetate-ether. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO 4 ), filtered and evaporated to 5.4 g of a solid. This material was converted to the hydrochloride as in Example 2 and recrystallized from isopropanol-methanol to give 4.8 g (83%) of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)acetamide hydrochloride, d 278° C. 
     ANALYSIS: Calculated for C 19  H 25  N 3  O.HCl: 65.59%C; 7.53%H; 12.08%N; Found: 65.42%C; 7.48%H; 12.00%N. 
     EXAMPLE 4 
     N-[1-(2-Phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)carbamic acid ethyl ester hydrochloride 
     To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 11 (4.1 g. 15 mmole) in 150 ml dichloromethane containing sodium bicarbonate (2.6 g, 30 mmole) was added a solution of ethyl chloroformate (1.9 g, 18 mmole) in 20 ml dichloromethane. After stirring twenty hours at ambient temperature, the mixture was evaporated to a solid that was stirred with water and extracted with ethyl acetate-ether. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO 4 ), filtered and evaporated to 5.2 g of a solid. 3.5 g of the solid was converted to the hydrochloride salt as in Example 2 then recrystallized from isopropanol to give 2.6 g (67%) of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)carbamic acid ethyl ester hydrochloride. 
     ANALYSIS: Calculated for C 20  H 27  N 3  O 2 .HCl: 63.55%C; 7.47%H; 11.12%N; Found: 63.93%C; 7.58%H; 11.32%N. 
     EXAMPLE 5 
     N-[1-(2-Phenethyl)-piperidin-4-yl]-N-(1H-pyrrol-1-yl)carbamic acid methyl ester hydrochloride 
     To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 11 (4 g, 15 mmole) in 150 ml dichloromethane containing sodium bicarbonate (2.5 g, 30 mmole) was added a solution of methyl chloroformate (1.6 g, 17 mmole) in 20 ml dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted with ethyl acetate-ether. The organic extract was washed with water, saturated NaCl and was dried (anhydrous MgSO 4 ), filtered and evaporated to an oil (4.7 g) that was purified by HPLC (silica gel, ethyl acetate/hexane/diethylamine-50/50/1) to give 3.7 g (76%) of a solid. This solid was converted to the hydrochloride salt as in Example 2 and recrystallized from isopropanol to give 3.6 g (67%) of N-[1-(2-phenethyl)-piperidin-4-yl]-N-(1H-pyrrol-1-yl)-carbamic acid methyl ester hydrochloride, d 222°-223° C. 
     ANALYSIS: Calculated for C 19  H 25  N 3  O 2 .HCl: 62.71%C; 7.20%H; 11.55%N; Found: 62.46%C; 7.35%H; 11.45%N. 
     EXAMPLE 6 
     N-[1-(2-Phenethyl)-piperidin-4-yl]-N-(1H-pyrrol-1-yl)cyanamide hydrochloride 
     To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 11, (4 g, 15 mmole) in 150 ml dichloromethane containing 2.5 g (30 mmole) sodium bicarbonate was slowly added a solution of cyanogen bromide (1.8 g, 17 mmole) in 25 ml dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted into ethyl acetate-ether. The organic extract was washed with water, saturated NaCl and was dried (anhydrous MgSO 4 ), filtered and evaporated to 5 g of an oil. This oil was converted to the hydrochloride salt as in Example 2 and recrystallized twice from isopropanol to give 2.7 g (55%) of N-[1-(2-phenethyl)-piperidin-4-yl]-N-(1H-pyrrol-1-yl)cyanamide hydrochloride, d 211°-212° C. 
     ANALYSIS: Calculated for C 18  H 22  N 4 .HCl: 65.34%C; 7.01%H; 16.94%N; Found: 65.04%C; 6.94%H; 17.06%N. 
     EXAMPLE 7 
     a. 1-[2-(4-chlorophenyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine 
     A mixture of 1-[2-(4-chlorophenyl)ethyl]-4-piperidone (8 g, 33.6 mmole) and 1-aminopyrrole (2.7 g, 33.6 mmole) in 100 ml of benzene was stirred at reflux for 6 hours. An additional 0.5 g of 1-aminopyrrole was added and reflux was continued for 2 hours whereafter an additional 0.5 g of 1-aminopyrrole was added and refluxing was continued overnight (about 16 hours). An additional 0.5 g of 1-aminopyrrole was added followed by refluxing for 6 hours. The resultant mixture was evaporated to yield 13 g of an oil. The oil was dissolved in 100 ml of isopropyl alcohol and 25 ml of methanol. To the solution was added NaBH 4  (2.6 g, 68 mmole) and the resultant mixture was refluxed for 2 hours. The mixture was cooled, evaporated with ethyl acetate/ether. The organic extract was washed with water, dried, filtered and evaporated to yield 12 g of an oil. The oil was purified by high pressure liquid chromatography (silica, 1% ethanol/ethylacetate) to give 9.6 g (94%) of an oil of 1-[2-(4-chlorophenyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine which solidified at room temperature upon standing. 
     b. N-{1-[2-(4-Chlorophenyl)ethyl]-piperidin-4-yl}-N-(1H-pyrrol-1-yl)carbamicacid ethyl ester hydrochloride 
     To a solution of 1-[2-(4-chlorophenyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine of Example 7a, (3.6 g, 12 mmole) in 100 ml dichloromethane containing sodium bicarbonate (2.5 g, 30 mmole) was added a solution of ethyl chloroformate (1.6 g, 15 mmole) in 20 ml of dichloromethane. The reaction mixture was stirred three hours at ambient temperature, then was evaporated, stirred with water and extracted with ethyl acetate-ether. The organic extracts were washed with water, saturated NaCl and were dried (anhydrous MgSO 4 ), filtered and evaporated to 4 g of an oil. This oil was purified by HPLC (silica gel; dichloromethane/ethyl acetate/diethylamine:100/20/1) to give 3.4 g of a solid. This material was converted to the hydrochloride salt as in Example 2 and recrystallized from isopropanol to give 2.8 g (58%) of N-{1-[2-(4-chlorophenyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol-1-yl)carbamic acid ethyl ester hydrochloride, d 253°-254° C. 
     ANALYSIS: Calculated for C 20  H 26  ClN 3  O 2 .HCL: 58.25%C; 6.60%H; 10.19%N; Found: 58.44%C; 6.58%H; 10.28%N. 
     EXAMPLE 8 
     N-{1-[2-(4-Chlorophenyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol-1-yl)propanamide 
     To a solution of 1-[2-(4-chlorophenyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine of Example 7a, (5 g, 16 mmole) in 150 ml dichloromethane containing sodium bicarbonate (3 g, 36 mmole) was added a solution of propionyl chloride (1.7 g, 18 mmole) in 20 ml dichloromethane. After stirring four hours at ambient temperature, the reaction mixture was washed with water, saturated sodium chloride and was dried (anhydrous MgSO 4 ), filtered and evaporated to give 6 g of a solid. This material was purified by HPLC (silica gel, 20% ethyl acetate/dichloromethane) to give 3.6 g (61%) of a solid, mp 80°-85° C. This was recrystallized from isopropyl ether/petroleum ether (1:1) to give 2.5 g (42%) of N-{1-[2-(4-chlorophenyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol-1-yl)propanamide, mp 85°-86° C. 
     ANALYSIS: Calculated for C 20  H 26  ClN 3  O: 66.74%C; 7.28%H; 11.68%N; Found: 66.54%C; 7.11%H; 12.00%N. 
     EXAMPLE 9 
     a. 1-(n-Butyl)-4-(1H-pyrrol-1-yl)aminopiperidine 
     A solution of 1-butyl-4-piperidone (6.2 g, 40 mmole) and 1-aminopyrrole (3.3 g, 40 mmole) in 100 ml of toluene was stirred at reflux overnight (about 16 hours). The mixture was cooled and then evaporated to an oil, which in turn was dissolved in 75 ml of isopropanol, and 22 ml of ethanol. To the solution was added NaBH 4  (3.8 g, 100 mole). The mixture was stirred at 70° C. for 2 hours and then evaporated, stirred with water and extracted with ethyl acetate-ether. The organic extract was washed with water and saturated NaCl solution, dried (anhydrous MgSO 4 ), filtered and evaporated to 13 g of an oil. This oil was purified by high pressure liquid chromatography (silica, 1% diethylamine/ethyl acetate) to give 8.2 g of an oil of 1-(n-butyl)-4-(1H-pyrrol-1-yl)aminopiperidine. 
     b. N-[1-(n-Butyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)carbamic acid ethyl ester 
     To a solution of 1-(n-butyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 9a, (4 g, 18 mmole) in 100 ml dichloromethane containing sodium bicarbonate (3 g, 36 mmole) was added a solution of ethyl chloroformate (2.3 g, 20 mmole) in 20 ml dichloromethane. After stirring three hours at ambient temperature the reaction mixture was evaporated, stirred with water and extracted with ethyl acetate. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO 4 ), filtered and evaporated to give 4.8 g of an oil. This oil was purified by HPLC (silica gel, ethyl acetate) to give 3.3 g (62%) of an oil. This oil was distilled to give 2.3 g (43%) of N-[1-(n-butyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)carbamic acid ethyl ester (b.p. 130°-140° C. @ 0.2 mm; m.p. 42°-43° C.). 
     ANALYSIS: Calculated for C 16  H 27  N 3  O 2  : 65.49%C; 9.28%H; 14.32%N; Found: 65.26%C; 9.04%H; 14.05%N. 
     EXAMPLE 10 
     N-[1-(n-Butyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)propanamide maleate 
     To a solution of 1-(n-butyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 9a, (3.5 g, 16 mmole) in 150 ml dichloromethane containing sodium bicarbonate (4 g, 48 mmole) was added a solution of propionyl chloride (1.6 g, 17 mmole) in 25 ml dichloromethane. After stirring five hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted with ether. The organic extract was washed with water, saturated NaCl and was dried (anhydrous MgSO 4 ), filtered and evaporated to 4 g of an oil. This oil was purified by HPLC (silica, 20% ethyl acetate in dichloromethane) to give 3.4 g (78%) of an oil. This oil was converted to the maleate salt as in Example 1 and recrystallized from isopropanol-ether to give 4 g (64%) of N-[1-(n-butyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)-propanamide maleate, mp 131°-132° C. 
     ANALYSIS: Calculated for C 16  H 27  N 3  O.C 4  H 4  O 4  : 61.05%C; 7.94%H; 10.68%N; Found: 61.14%C; 7.91%H; 10.66%N. 
     EXAMPLE 11 
     1-(2-Phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine maleate 
     A mixture of 1-(β-phenethyl)-4-piperidone (12.4 g, 61 mmole) and 1-aminopyrrole (5 g, 61 mmole) in 100 ml benzene was stirred seven hours at reflux. After cooling, the mixture was evaporated, dissolved in 100 ml isopropanol and 25 ml methanol, and to this solution was added sodium borohydride (4.6 g, 121 mmole). The mixture stirred two hours at 70° C. then was cooled, evaporated, stirred with water and extracted into ethyl acetate-ether. The organic extract was washed with water, saturated NaCl and was dried (anhydrous MgSO 4 ), filtered and evaporated to 17 g of an oil. This oil was purified by HPLC (silica, ethyl acetate) to give 14 g (85%) of a solid, mp 45°-47° C. Two grams of this material was converted to the maleate salt as in Example 1 and recrystallized from isopropanol-ether to give 2.5 g of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine maleate, mp 147°-148° C. 
     ANALYSIS: Calculated for C 17  H 23  N 3 .C 4  H 4  O 4  : 65.43%C; 7.06%H; 10.90%N; Found: 65.29%C; 7.07%H; 10.88%N. 
     EXAMPLE 12 
     1-[2-(4-Methoxyphenyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine 
     A solution of 1-[2-(4-methoxyphenyl)ethyl]-4-piperidone (15 g, 64 mmole) and 1-aminopyrrole (6 g, 73 mmole) in 125 ml of benzene was stirred at 120° C. for 20 hours. The resultant solution was evaporated, dissolved in 125 ml of isopropanol and 50 ml of methanol and then NaBH 4  (6 g, 158 mmole) was added. The resultant mixture was stirred 3 hours at 75° C., cooled, evaporated, stirred with water and then extracted with ethyl acetate-ether. The organic extract was washed with water and saturated NaCl solution, dried, (anhydrous MgSO 4 ), filtered and evaporated to 19.7 g of an oil. This oil was purified by high pressure liquid chromatography (silica, 3% methanol/dichloromethane) to give 14.7 g (76.6%) of a solid. 0.5 g of this solid was recrystallized from isopropyl ether to give 0.1 g of 1-[2-(4-methoxyphenyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine. 
     ANALYSIS: Calculated for C 18  H 25  N 3  O: 72.20%C; 8.42%H; 14.04%N; Found: 72.51%C; 8.40%H; 14.10%N; 
     b. N-{1-[2-(4-Methoxyphenyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol-1-yl)propanamide 
     To a solution of 1-[2-(4-methoxyphenyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine of Example 12a, (3.6 g, 12 mmole) in 100 ml dichloromethane containing sodium bicarbonate (2 g, 24 mmole) was added a solution of propionyl chloride (1.1 g, 12 mmole) in 20 ml dichloromethane. After stirring two hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted into ethyl acetate-ether. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO 4 ), filtered and evaporated to give 4 g of a solid. This material was recrystallized from isopropyl etherpetroleum ether (1:1) to give 2.8 g (65%) of N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol-1-yl)propanamide, mp 83°-84° C. 
     ANALYSIS: Calculated for C 21  H 29  N 3  O 2  : 70.95%C; 8.22%H; 11.82%N; Found: 70.98%C; 8.24%H; 11.76%N. 
     EXAMPLE 13 
     N-{1-[2-(4-Methoxyphenyl)ethyl]piperidin-4-yl})-N-(1H-pyrrol-1-yl)cyanamide hydrochloride 
     To a solution of 1-[2-(4-methoxyphenyl)ethyl]-4-ethyl-4-(1H-pyrrol-1-yl)aminopiperidine of Example 12a (4 g, 13.4 mmole) in 150 ml dichloromethane containing sodium bicarbonate (3.4 g, 40 mmole) was added a solution of cyanogen bromide (1.6 g, 14.7 mmole) in 25 ml dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted with ether. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO 4 ), filtered and evaporated to 5 g of an oil. The oil was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol-ether to give 2.8 g (58%) of N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol-1-yl)cyanamide hydrochloride, d 227°-229° C. 
     ANALYSIS: Calculated for C 19  H 24  N 4  O.HCl: 63.23%C; 6.98%H; 15.53%N; Found: 63.17%C; 6.92%H; 15.42%N. 
     EXAMPLE 14 
     1-(2-Phenethyl)-4-[N-(n-propyl)-N-(1H-pyrrol-1-yl)]aminopiperidine oxalate 
     To a solution of borane-tetrahydrofuran (THF) complex (0.97M in THF, 86 mmole, 86 ml), cooled with an ice bath, was slowly added a solution of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)propanamide of Example 2, (7 g, 22 mmole) in 25 ml tetrahydrofuran. After stirring three hours at ambient temperature the reaction mixture was cooled and excess borane was quenched by slow addition of 3N HCl. The mixture was then basified with sodium carbonate and the oil which separated was extracted with ethyl acetate-ether. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO 4 ), filtered and evaporated to give 8 g of a solid, mp 121°-123° C. A mixture of this solid in 175 ml 3N HCl was stirred three hours at 105° C., then was cooled, diluted with water and basified with sodium carbonate. The oil which separated was extracted with ethyl-acetate ether. The organic extract was washed with water, saturated NaCl and was dried (anhydrous MgSO 4 ), filtered and evaporated to give 7 g of an oil. This oil was purified by HPLC (silica, ethyl acetate) to give 5 g (75%) of an oil. This oil was converted to the oxalate salt as in Example 1 and was recrystallized from isopropanol to give 5.5 g (64%) of 1-(2-phenethyl)-4-[N-(n-propyl)-N-(1H-pyrrol-1-yl)]aminopiperidine oxalate, d 188°-190° C. 
     ANALYSIS: Calculated for C 20  H 29  N 3 .C 2  H 2  O 4  : 65.81%C; 7.78%H; 10.47%N; Found: 65.88%C; 7.71%H; 10.36%N. 
     EXAMPLE 15 
     a. 1-(2-Phenylpropyl)-4-(1H-pyrrol-1-yl)aminopiperidine 
     A solution of 1-aminopyrrole (6 g, 73.1 mmole) and 1-(2-phenylpropyl)-4-piperidone (13.8 g, 63.5 mmole) in 100 ml of benzene was stirred at reflux for 3 hours. The resultant mixture was evaporated, dissolved in 100 ml of isopropanol and 25 ml of ethanol and to the resultant solution was added NaBH 4  (4.8 g, 0.13 mole). The resultant mixture was stirred 2 hours at 70° C. and then kept at room temperature for 3 days. The mixture was evaporated, stirred with water and extracted with ether. The organic extract was washed with water and saturated NaCl solution and was dried (anhydrous MgSO 4 ), filtered and evaporated to 18 g of an oil. This oil was purified by high pressure liquid chromatography (silica, 3% methanol/dichloromethane) to give 14 g (77.8%) of an oil which on cooling yielded a solid of 1-(2-phenylpropyl)-4-(1H-pyrrol-1-yl)aminopiperidine, m.p. 72°-74° C. 
     b. N-[1-(2-Phenylpropyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)propanamide hydrochloride 
     To a solution of 1-(2-phenylpropyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 15a, (3.5 g, 12.3 mmole) in 100 ml dichloromethane containing sodium bicarbonate (3.1 g, 37 mmole) was added a solution of propionyl chloride (1.3 g, 13.6 mmole) in 20 ml dichloromethane. After stirring six hours at ambient temperature the reaction mixture was evaporated, stirred with water and extracted into ether. The organic extract was washed with water, saturated sodium chloride and was dried (anhydrous MgSO 4 ), filtered and evaporated to give 5 g of an oil. This oil was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol-ether to give 4.1 g (89%) of N-[1-(2-phenylpropyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)propanamide hydrochloride, d 258°-259° C. 
     ANALYSIS: Calculated for C 21  H 29  N 3  O.HCl: 67.09%C; 8.04%H; 11.18%N; Found: 67.14%C; 7.98%H; 11.15%N. 
     EXAMPLE 16 
     N-[1-(2-Phenylpropyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)carbamic acid ethyl ester hydrochloride 
     To a solution of 1-(2-phenylpropyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 15a (3.5 g, 13.2 mmole) in 100 ml dichloromethane containing sodium bicarbonate (4 g, 48 mmole) was added a solution of ethyl chloroformate (1.6 g, 15 mmole) in 20 ml dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted into ether. The organic extract was washed with water, saturated NaCl and was dried (anhydrous MgSO 4 ), filtered and evaporated to give 4.5 g of an oil. The oil was purified by HPLC (silica gel, ethyl acetate) to give 3.6 g (82%) of an oil. This oil was converted to the hydrochloride salt as in Example 2 then recrystallized from isopropanol-ether to give 3.1 g (64%) of N-[1-(2-phenylpropyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)carbamic acid ethyl ester hydrochloride 
     ANALYSIS: Calculated for C 21  H 29  N 3  O 2 .HCl: 64.35%C; 7.72%H; 10.72%N; Found: 64.26%C; 7.76%H; 10.54%N. 
     EXAMPLE 17 
     N-[1-(2-Phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)carbamic acid-(n-butyl)-ester hydrochloride 
     To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl) aminopiperidine of Example 11 (5 g, 10 mmole) in 150 ml dichloromethane containing sodium bicarbonate (3 g, 36 mmole) was added a solution of butyl chloroformate (2.8 g, 20 mmole) in 20 ml dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted with ether. The organic extract was washed with water and saturated sodium chloride and was dried (anhydrous MgSO 4 ), filtered and evaporated to give 7 g of an oil. This oil was purified by HPLC (silica gel, 10% ethyl acetate in dichloromethane) to give 5.2 g (75%) of a solid mp 60° C. This material was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol-ether to give 3.2 g (42%) of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)carbamic acid-(n-butyl)-ester hydrochloride, d 216°-217° C. 
     ANALYSIS: Calculated for C 22  H 31  N 3  O 2 .HCl: 65.09%C; 7.95%H; 10.35%N; Found: 65.37%C; 7.96%H; 10.38%N. 
     EXAMPLE 18 
     N-[1-(2-Phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)acrylamide hydrochloride 
     To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 11 (4 g, b 14.8 mmole) in 150 ml dichloromethane containing sodium bicarbonate (4 g, 48 mmole) was added a solution of acryloyl chloride (1.5 g, 17 mmole) in 20 ml dichloromethane. After stirring twenty hours at ambient temperature the reaction mixture was evaporated, stirred with water and extracted with ethyl acetate-ether. The organic extract was washed with water and saturated sodium chloride and was dried (anhydrous MgSO 4 ), filtered and evaporated to 4.8 g of a solid. This material was purified by HPLC (silica gel, 20% ethyl acetate in dichloromethane) to give 3.3 g (69%) of a solid. This material was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol to give 3.2 g (60%) of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)acrylamide hydrochloride, d 278°-279° C. 
     ANALYSIS: Calculated for C 20  H 25  N 3  O.HCl: 66.74%C; 7.28%H; 11.68%N; Found: 66.64%C; 7.28%H; 11.76%N. 
     EXAMPLE 19 
     N-[1-(2-Phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)-N&#39;-methylurea hydrochloride 
     A solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 11 (3.5 g, 13 mmole) and methyl isocyanate (0.8 g, 14 mmole) in 125 ml benzene was stirred at 50° C. for four hours, then was cooled and evaporated to a solid. This material was dissolved in warm isopropanol and converted to the hydrochloride salt as in Example 2. Upon cooling, the product precipitated and was collected to give 3.6 g (76%) of a solid, d 250°-251° C. This material was again recrystallized from isopropanol to give 3.2 g (68%) of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)-N&#39;-methylurea hydrochloride, d 252°-253° C. 
     ANALYSIS: Calculated for C 19  H 26  N 4  O.HCl: 62.88%C; 7.50%H; 15.44%N; Found: 62.99%C; 7.55%H; 15.31%N. 
     EXAMPLE 20 
     a. 1-[2-(2-Thienyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine 
     A solution of 1-(2-thienylethyl)-4-piperidone (24.6 g, 0.12 mole) and 1-aminopyrrole (12 g, 0.15 mole) in 200 ml of benzene was stirred at reflux for 4 hours. The resultant mixture was cooled and evaporated to an oil which in turn was dissolved in 200 ml of isopropanol and 50 ml of methanol. To the resultant solution was added NaBH 4  (9.1 g, 0.24 mole). The mixture was stirred at 80° C. for 2 hours, cooled, evaporated, stirred with water and then extracted with ethyl acetate-ether. The organic extract was washed twice with water and saturated NaCl solution and was dried (anhydrous MgSO 4 ), filtered and evaporated to 33 g of an oil of 1-[2-(2-thienyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine. 
     b. N-{1-[2-(2-Thienyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol-1-yl)propanamide hydrochloride 
     To a solution of 1-[2-(2-thienyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine of Example 20a (5 g, 18 mmole) in 150 ml dichloromethane containing sodium bicarbonate (5 g, 60 mmole) was added a solution of propionyl chloride (2 g, 22 mmole) in 20 ml dichloromethane. After stirring two hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted into ethyl acetate-ether. The organic extract was washed with water and saturated sodium chloride and was dried (anhydrous MgSO 4 ), filtered and evaporated to give 6.2 g of an oil. This oil was purified by HPLC (silica gel, 20% ethyl acetate in dichloromethane) to give 4 g (67%) of an oil. This oil was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol to give 4.3 g (63%) of N-{1-[2-(2-thienyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol-1-yl)propanamide hydrochloride, d 276°-277° C. 
     ANALYSIS: Calculated for C 18  H 25  N 3  OS.HCl: 58.75%C; 7.12 %H; 11.42%N; Found: 58.82%C; 7.15%H; 11.17%N. 
     EXAMPLE 21 
     N-[1-(2-Phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)cyclobutanecarboxylic acid amide hydrochloride 
     To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine of Example 11 (4.4 g, 16 mmole) in 150 ml dichloromethane containing sodium bicarbonate (5 g, 60 mmole) was added a solution of cyclobutanecarboxylic acid chloride (2.1 g, 18 mmole) in 25 ml dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted with ether. The organic extract was washed with water and saturated sodium chloride and was dried (anhydrous MgSO 4 ), filtered and evaporated to 6.5 g of a solid. This material was purified by HPLC (silica gel, 25% ethyl acetate in dichloromethane) to give 5.2 g (91%) of a solid mp 103°-105° C. This material was converted to the hydrochloride salt as in Example 2 in warm isopropanol and, upon cooling, yielded 5.0 g (79%) of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)cyclobutanecarboxylic acid amide hydrochloride, d 264°- 265° C. 
     ANALYSIS: Calculated for C 22  H 29  N 3  O.HCl: 68.11%C; 7.79%H; 10.83%N; Found: 68.24%C; 7.68%H; 10.78%N. 
     EXAMPLE 22 
     N-{1-[2-(2-Thienyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol-1-yl)carbamic acid ethyl ester hydrochloride 
     To a solution of 1-[2-(2-thienyl)ethyl]-4-(1H-pyrrol-1-yl)aminopiperidine of Example 20a (5 g, 18 mmole) in 150 ml dichloromethane containing sodium bicarbonate (5 g, 60 mmole) was added a solution of ethyl chloroformate (2.4 g, 22 mmole) in 20 ml dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was evaporated, stirred with water and extracted with ethyl acetate-ether. The organic extract was washed with water and saturated sodium chloride and was dried (anhydrous MgSO 4 ), filtered and evaporated to give 6.3 g of a solid. This solid was purified by HPLC (silica gel, 20% ethyl acetate in dichloromethane) to give 4 g (64%) of a solid mp 104°-106° C. This material was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol to give 4 g (57%) of N-{1-[2-(2-thienyl)ethyl]piperidin-4-yl}-N-(1H-pyrrol- 1yl)carbamic acid ethyl ester hydrochloride, d 212°-213° C. 
     ANALYSIS: Calculated for C 18  H 25  N 3  O 2  S.HCl: 56.31%C; 6.83%H; 10.95%N; Found: 56.22%C; 6.85%H; 10.86%N. 
     EXAMPLE 23 
     N-[1-(2-Phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)propanethioamide hydrochloride 
     A mixture of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)propanamide of Example 2 (4.2 g, 13 mmole) and p-methoxyphenylthionophosphine sulfide dimer (2.2 g, 6.5 mmole) in 25 ml dioxane was stirred at 70° C. for two hours then was cooled, stirred with 500 ml water and was extracted with ethyl acetate. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO 4 ), filtered and evaporated to 6 g of an oil. This oil was converted to the hydrochloride salt as in Example 2 and was recrystallized from isopropanol to give 2.1 g (43%) N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)propanethioamide hydrochloride, d 252°-253° C. 
     ANALYSIS: Calculated for C 20  H 27  N 3  S.HCl: 63.55%C; 7.47%H; 11.12%N; Found: 63.65%C; 7.39%H; 11.01%N. 
     EXAMPLE 24 
     N-[1(2-Phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)cyclopropanecarboxylic acid amide hydrochloride 
     To a solution of 1-(2-phenethyl)-4-(1H-pyrrol-1-yl)aminopiperidine (4 g, 15 mmole) in 150 ml of dichloromethane containing sodium bicarbonate (4 g, 48 mmole), was added a solution of cyclopropanecarboxylic acid chloride (1.8 g, 17 mmole) in 20 ml of dichloromethane. After stirring for two hours at ambient temperature, the reaction mixture was washed with water and saturated sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and evaporated. The residue was purified by high performance liquid chromatography (silica gel, 20% ethyl acetate in dichloromethane) to give 3.3 g (66%) of product. The product was dissolved in 100 ml of warm isopropanol and converted to the hydrochloride salt, mp 282° C. dec. 
     ANALYSIS: Calculated for C 21  H 27  N 3  O.HCl: 67.45%C; 7.55%H; 11.24%N; Found: 67.44%C; 7.45%H; 11.04%N. 
     EXAMPLE 25 
     N-(2-Methyl-1H-pyrrol-1-yl)-N-[1-(2-phenethyl)piperidin-4-yl]carbamic acid ethyl ester hydrochloride 
     To a solution of 1-(2-phenethyl)-4-(2-methyl-1H-pyrrol-1-yl)aminopiperidine (4 g, 14.1 mmole) in 125 ml of dichlormethane containing sodium bicarbonate (5 g, 60 mmole), was added a solution of ethyl chloroformate (1.8 g, 16.6 mmole) in 25 ml of dichloromethane. After stirring five hours at ambient temperature, the reaction mixture was washed with water, dried over anhydrous magnesium sulfate, filtered and evaporated. The residue was purified by high performance liquid chromatography (silica gel, 20% ethyl acetate in dichloromethane) to give 3 g (60%) of product, mp 489°-50° C. The product was dissolved in 75 ml of warm isopropanol and converted to the hydrochloride salt. The salt, which crystallized upon dilution with ether, had a mp of 212°-214° C., dec. 
     ANALYSIS: Calculated for C 21  H 29  N 3  O 2 .HCl: 64.35%C; 7.72%H; 10.72%N; Found: 64.48%C; 7.66%H; 10.56%N. 
     EXAMPLE 26 
     N-[1-(2-Phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)ethanethioamide hydrochloride 
     To a solution of N-[1-(2-phenethyl)piperidin-4-yl]-N-(1H-pyrrol-1-yl)acetamide (3.5 g, 11.2 mmole) in 25 ml of dioxane was added 4-methoxyphenylthionophosphine sulfide dimer (1.9 g, 5.6 mmole). The reaction mixture was stirred at 80° C. for two hours, cooled, stirred with water and extracted with ethyl acetate. The organic extract was washed with water and saturated sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and evaporated. The residue was dissolved in ethyl acetate and converted to the hydrochloride salt. The salt was collected and rebasified with sodium carbonate solution to give a solid. The solid was purified by high performance liquid chromatography (silica gel, 10% ethyl acetate in dichloromethane) to give 2.8 g (76%) of product, mp 120°-122° C. The product was dissolved in 100 ml of warm isopropanol and converted to the hydrochloride salt, mp 268°-270° C. 
     ANALYSIS: Calculated for C 19  H 25  N 3  S.HCl: 62.70%C; 7.20%H; 11.55%N; Found: 62.89%C; 7.16%H; 11.43%N. 
     EXAMPLE 27 
     N-(2-Methyl-1H-pyrrol-1-yl)-N-[1-(2-phenethyl)piperidin-4-yl]acetamide hydrochloride 
     To a solution of 1-(2-phenethyl)-4-(2-methyl-1H-pyrrol-1-yl)aminopiperidine (5 g, 17.6 mmole) in 125 ml of dichloromethane containing sodium bicarbonate (5 g, 60 mmole), was added a solution of acetyl chloride (1.7 g, 21.6 mmole) in 25 ml of dichloromethane. After stirring twenty hours at ambient temperature, the reaction mixture was washed with water, dried over anhydrous magnesium sulfate, filtered and evaporated. The residue was purified by high performance liquid chromatography (silica gel, 20% ethyl acetate in dichloromethane) to give 3.7 g (65%) of product. The product was converted to the hydrochloride salt, which had mp 269°-270° C., dec., after recrystallization from isopropanol-ether. 
     ANALYSIS: Calculated for C 20  H 27  N 3  O.HCl: 66.37%C; 7.80%H; 11.61%N; Found: 66.26%C; 7.70%H; 11.53%N.