Patent Publication Number: US-11045254-B2

Title: Steerable laser probe

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application is a continuation of prior application Ser. No. 15/857,984 filed Dec. 29, 2017, which is a continuation of U.S. Pat. No. 9,888,965, filed Aug. 16, 2017, which is a continuation of U.S. Pat. No. 9,770,298, filed Jul. 12, 2013, which is a non-provisional application of prior provisional application No. 61/681,702, filed Sep. 12, 2012, the entire disclosure of which are incorporated herein by reference. 
    
    
     STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH 
     Not applicable. 
     BACKGROUND 
     The present disclosure relates to a surgical instrument, and, more particularly, to a steerable laser probe. 
     A wide variety of ophthalmic procedures require a laser energy source. For example, ophthalmic surgeons may use laser photocoagulation to treat proliferative retinopathy. Proliferative retinopathy is a condition characterized by the development of abnormal blood vessels in the retina that grow into the vitreous humor. Ophthalmic surgeons may treat this condition by energizing a laser to cauterize portions of the retina to prevent the abnormal blood vessels from growing and hemorrhaging. 
     In order to increase the chances of a successful laser photocoagulation procedure, it is important that a surgeon is able aim the laser at a plurality of targets within the eye, e.g., by guiding or moving the laser from a first target to a second target within the eye. It is also important that the surgeon is able to easily control a movement of the laser. For example, the surgeon must be able to easily direct a laser beam by steering the beam to a first position aimed at a first target, guide the laser beam from the first position to a second position aimed at a second target, and hold the laser beam in the second position. Accordingly, there is a need for a surgical laser probe that can be easily guided to a plurality of targets within the eye. 
     BRIEF DESCRIPTION 
     The present disclosure provides a steerable laser probe. In one or more embodiments, a steerable laser probe may comprise a handle having a handle distal end and a handle proximal end, a plurality of actuation controls of the handle, a flexible housing tube having a flexible housing tube distal end and a flexible housing tube proximal end, and an optic fiber disposed within an inner bore of the handle and the flexible housing tube. Illustratively, an actuation of an actuation control of the plurality of actuation controls may be configured to gradually curve the flexible housing tube. In one or more embodiments, a gradual curving of the flexible housing tube may be configured to gradually curve the optic fiber. Illustratively, an actuation of an actuation control of the plurality of actuation controls may be configured to gradually straighten the flexible housing tube. In one or more embodiments, a gradual straightening of the flexible housing tube may be configured to gradually straighten the optic fiber. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       The present inventive subject matter will be better understood from reading the following description of non-limiting embodiments, with reference to the attached drawings, wherein below: 
         FIGS. 1A and 1B  are schematic diagrams illustrating an exploded view of a handle assembly; 
         FIGS. 2A and 2B  are schematic diagrams illustrating a handle; 
         FIG. 3  is a schematic diagram illustrating a flexible housing tube; 
         FIG. 4  is a schematic diagram illustrating an exploded view of a steerable laser probe assembly; 
         FIGS. 5A, 5B, 5C, 5D, and 5E  are schematic diagrams illustrating a gradual curving of an optic fiber; 
         FIGS. 6A, 6B, 6C, 6D, and 6E  are schematic diagrams illustrating a gradual straightening of an optic fiber; 
         FIGS. 7A and 7B  are schematic diagrams illustrating an exploded view of a handle assembly; 
         FIGS. 8A and 8B  are schematic diagrams illustrating a handle; 
         FIG. 9  is a schematic diagram illustrating a flexible housing tube; 
         FIG. 10  is a schematic diagram illustrating an exploded view of a steerable laser probe assembly; 
         FIGS. 11A, 11B, 11C, 11D, and 11E  are schematic diagrams illustrating a gradual curving of an optic fiber; 
         FIGS. 12A, 12B, 12C, 12D, and 12E  are schematic diagrams illustrating a gradual straightening of an optic fiber. 
     
    
    
     Corresponding reference numerals indicate corresponding parts throughout the several figures of the drawings. 
     DETAILED DESCRIPTION 
     The following detailed description illustrates the inventive subject matter by way of example and not by way of limitation. The description enables one of ordinary skill in the art to make and use the inventive subject matter, describes several embodiments of the inventive subject matter, as well as adaptations, variations, alternatives, and uses of the inventive subject matter. Additionally, it is to be understood that the inventive subject matter is not limited in its application to the details of construction and the arrangements of components set forth in the following description or illustrated in the drawings. The inventive subject matter is capable of other embodiments and of being practiced or being carried out in various ways. Also, it is to be understood that the phraseology and terminology used herein is for the purpose of description and should not be regarded as limiting on all embodiments of the inventive subject matter. 
     The terminology used herein is for the purpose of describing particular exemplary embodiments only and is not intended to be limiting. As used herein, the singular forms “a”, “an” and “the” may be intended to include the plural forms as well, unless the context clearly indicates otherwise. The terms “comprises,” “comprising,” “including,” and “having,” are inclusive and therefore specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. The steps, processes, and operations described herein are not to be construed as necessarily requiring their respective performance in the particular order discussed or illustrated, unless specifically identified as a preferred order of performance. It is also to be understood that additional or alternative steps may be employed. 
       FIGS. 1A and 1B  are schematic diagrams illustrating an exploded view of a handle assembly  100 .  FIG. 1A  illustrates a side view of handle assembly  100 . In one or more embodiments, handle assembly  100  may comprise a handle end cap  105  having a handle end cap distal end  106  and a handle end cap proximal end  107 , an actuation mechanism  110  having an actuation mechanism distal end  111  and an actuation mechanism proximal end  112 , and a handle base  130  having a handle base distal end  131  and a handle base proximal end  132 . Illustratively, actuation mechanism  110  may comprise a plurality of actuation controls  120 . For example, each actuation control  120  of a plurality of actuation controls  120  may comprise an actuation control distal end  121  and an actuation control proximal end  122 . In one or more embodiments, handle base  130  may comprise a plurality of handle base limbs  133 , a plurality of handle base channels  134 , and a handle end cap interface  135 . 
       FIG. 1B  illustrates a cross-sectional view of handle assembly  100 . In one or more embodiments, handle assembly  100  may comprise a proximal chamber  140 , a handle base housing  150 , a handle base interface  155 , an optic fiber guide  160 , an inner bore  170 , optic fiber housing  175 , an actuation mechanism guide  180 , a pressure mechanism housing  185 , and a housing tube housing  190 . Handle end cap  105 , actuation mechanism  110 , actuation control  120 , and handle base  130  may be manufactured from any suitable material, e.g., polymers, metals, metal alloys, etc., or from any combination of suitable materials. 
       FIGS. 2A and 2B  are schematic diagrams illustrating a handle  200 .  FIG. 2A  illustrates a side view of handle  200 . In one or more embodiments, handle  200  may comprise a handle distal end  201 , a handle proximal end  202 , and a plurality of actuation control guides  210 . For example, each actuation control guide  210  of a plurality of actuation control guides  210  may comprise an actuation control guide distal end  211  and an actuation control guide proximal end  212 . Illustratively, handle distal end  201  may comprise handle base distal end  131 . In one or more embodiments, handle proximal end  202  may comprise handle end cap proximal end  107 . 
       FIG. 2B  illustrates a cross-sectional view of handle  200 . Illustratively, actuation mechanism  110  may be disposed within handle end cap  105  and handle base  130 . In one or more embodiments, a portion of actuation mechanism  110  may be disposed within handle base housing  150 , e.g., actuation mechanism proximal end  112  may be disposed within handle base housing  150 . Illustratively, a portion of actuation mechanism  110  may be disposed within actuation mechanism guide  180 , e.g., actuation mechanism distal end  111  may be disposed within actuation mechanism guide  180 . In one or more embodiments, a portion of handle base  130  may be disposed within handle end cap  105 , e.g., handle base proximal end  132  may be disposed within handle end cap  105 . Illustratively, a portion of handle base  130  may be disposed within handle base housing  150 . In one or more embodiments, a portion of handle base  130  may be disposed within handle base housing  150 , e.g., handle base proximal end  132  may be configured to interface with handle base interface  155 . Illustratively, a portion of handle base  130  may be disposed within handle base housing  150 , e.g., handle end cap distal end  106  may be configured to interface with handle end cap interface  135 . In one or more embodiments, a portion of handle base  130  may be fixed within a portion of handle end cap  105 , e.g., by an adhesive or any suitable fixation means. For example, a portion of handle base  130  may be fixed within handle base housing  150 , e.g., by an adhesive or any suitable fixation means. 
     Illustratively, each actuation control  120  of a plurality of actuation controls  120  may be disposed within an actuation control guide  210  of a plurality of actuation control guides  210 . In one or more embodiments, each actuation control guide  210  of a plurality of actuation control guides  210  may comprise a handle base channel  134  of a plurality of handle base channels  134 . In one or more embodiments, at least one actuation control  120  may be configured to actuate within at least one actuation control guide  210 . Illustratively, each actuation control  120  of a plurality of actuation controls  120  may be configured to actuate within an actuation control guide  210  of a plurality of actuation control guides  210 . In one or more embodiments, an actuation of a particular actuation control  120  in a particular actuation control guide  210  may be configured to actuate each actuation control  120  of a plurality of actuation controls  120 . In one or more embodiments, actuation controls  120  may be configured to actuate within actuation control guides  210  in pairs or groups. Illustratively, an actuation of first actuation control  120  within a first actuation control guide  210  may be configured to actuate a second actuation control  120  within a second actuation control guide  210 . 
     In one or more embodiments, actuation mechanism  110  may be configured to actuate within actuation mechanism guide  180 . For example, actuation mechanism guide  180  may comprise a lubricant configured to facilitate an actuation of actuation mechanism  110  within actuation mechanism guide  180 . Illustratively, an actuation of an actuation control  120  within an actuation control guide  210  may be configured to actuate actuation mechanism  110 , e.g., within actuation mechanism guide  180 . In one or more embodiments, an actuation of an actuation control  120  towards an actuation control guide distal end  211 , e.g., and away from an actuation control guide proximal end  212 , may be configured to actuate actuation mechanism  110  towards handle distal end  201 , e.g., and away from handle proximal end  202 . Illustratively, an actuation of an actuation control  120  towards an actuation control guide proximal end  212 , e.g., and away from an actuation control guide distal end  211 , may be configured to actuate actuation mechanism towards handle proximal end  202 , e.g., and away from handle distal end  201 . 
     In one or more embodiments, a surgeon may actuate actuation mechanism  110  within actuation mechanism guide  180 , e.g., by manipulating an actuation control  120  of a plurality of actuation controls  120  when handle  200  is in a first rotational orientation. Illustratively, the surgeon may rotate handle  200  and actuate actuation mechanism  110  within actuation mechanism guide  180 , e.g., by manipulating an actuation control  120  of a plurality of actuation controls  120  when handle  200  is in a second rotational orientation. In one or more embodiments, the surgeon may rotate handle  200  and actuate actuation mechanism  110  within actuation mechanism guide  180 , e.g., by manipulating an actuation control  120  of a plurality of actuation controls  120  when handle  200  is in a third rotational orientation. Illustratively, a surgeon may actuate actuation mechanism  110  within actuation mechanism guide  180 , e.g., by manipulating an actuation control  120  of a plurality of actuation controls  120  when handle  200  is in any rotational orientation of a plurality of rotational orientations. 
       FIG. 3  is a schematic diagram illustrating a flexible housing tube  300 . Illustratively, flexible housing tube  300  may comprise a flexible housing tube distal end  301  and a flexible housing tube proximal end  302 . Flexible housing tube  300  may be manufactured from any suitable material, e.g., polymers, metals, metal alloys, etc., or from any combination of suitable materials. Illustratively, flexible housing tube  300  may comprise a shape memory material, e.g., Nitinol. In one or more embodiments, flexible housing tube  300  may be manufactured from a material having an ultimate tensile strength between 700 and 1000 MPa. Illustratively, flexible housing tube  300  may be manufactured from a material having ultimate tensile strength less than 700 MPa or greater than 1000 MPa. In one or more embodiments, flexible housing tube  300  may be manufactured from a material having a modulus of elasticity between 30 and 80 GPa. Illustratively, flexible housing tube  300  may be manufactured from a material having a modulus of elasticity less than 30 GPa or greater than 80 GPa. 
     In one or more embodiments, flexible housing tube  300  may be manufactured with dimensions suitable for performing microsurgical procedures, e.g., ophthalmic surgical procedures. Illustratively, flexible housing tube  300  may be manufactured at gauge sizes commonly used in ophthalmic surgical procedures, e.g., 23 gauge, 25 gauge, etc. In one or more embodiments, flexible housing tube  300  may be configured to be inserted in a cannula, e.g., a cannula used during an ophthalmic surgical procedure. For example, one or more properties of flexible housing tube  300  may be optimized to reduce friction as flexible housing tube  300  is inserted into a cannula. In one or more embodiments, one or more properties of flexible housing tube  300  may be optimized to reduce friction as flexible housing tube  300  is removed from a cannula. Illustratively, flexible housing tube  300  may have an ultimate tensile strength between 1000 MPa and 1100 MPa. In one or more embodiments, flexible housing tube  300  may have an ultimate tensile strength less than 1000 MPa or greater than 1100 MPa. 
     In one or more embodiments, an optic fiber  310  may be disposed within flexible housing tube  300 . Illustratively, optic fiber  310  may comprise an optic fiber distal end  311  and an optic fiber proximal end  312 . In one or more embodiments, optic fiber  310  may be configured to transmit light, e.g., laser light. Illustratively, optic fiber  310  may be disposed within flexible housing tube  300  wherein optic fiber distal end  311  may be adjacent to flexible housing tube distal end  301 . In one or more embodiments, a portion of optic fiber  310  may be fixed to a portion of flexible housing tube  300 , e.g., by an adhesive or any suitable fixation means. 
       FIG. 4  is a schematic diagram illustrating an exploded view of a steerable laser probe assembly  400 . In one or more embodiments, steerable laser probe assembly  400  may comprise a handle  200 , a flexible housing tube  300  having a flexible housing tube distal end  301  and a flexible housing tube proximal end  302 , an optic fiber  310  having an optic fiber distal end  311  and an optic fiber proximal end  312 , and a light source interface  410 . Illustratively, light source interface  410  may be configured to interface with optic fiber  310 , e.g., at optic fiber proximal end  312 . In one or more embodiments, light source interface  410  may comprise a standard light source connecter, e.g., an SMA connector. 
     Illustratively, a portion of flexible housing tube  300  may be fixed to a portion of handle  200 , e.g., flexible housing tube proximal end  302  may be fixed to handle distal end  201 . In one or more embodiments, a portion of flexible housing tube  300  may be fixed to a portion of handle  200 , e.g., by an adhesive or any suitable fixation means. Illustratively, a portion of flexible housing tube  300  may be disposed within flexible housing tube housing  190 , e.g., flexible housing tube proximal end  302  may be disposed within flexible housing tube housing  190 . In one or more embodiments, a portion of flexible housing tube  300  may be fixed within flexible housing tube housing  190 , e.g., by an adhesive or any suitable fixation means. For example, flexible housing tube  300  may be fixed within flexible housing tube housing  190  by a press fit, a setscrew, etc. 
     In one or more embodiments, optic fiber  310  may be disposed in optic fiber guide  160 , inner bore  170 , optic fiber housing  175 , actuation mechanism guide  180 , flexible housing tube housing  190 , and flexible housing tube  300 . Illustratively, optic fiber  310  may be disposed within flexible housing tube  300  wherein optic fiber distal end  311  may be adjacent to flexible housing tube distal end  301 . In one or more embodiments, a portion of optic fiber  310  may be fixed to a portion of flexible housing tube  300 , e.g., by an adhesive or any suitable fixation means. Illustratively, a portion of optic fiber  310  may be fixed to a portion of actuation mechanism  110 , e.g., a portion of optic fiber  310  may be fixed within optic fiber housing  175 . In one or more embodiments, a portion of optic fiber  310  may be fixed within optic fiber housing  175 , e.g., by an adhesive or any suitable fixation means. For example, a portion of optic fiber  310  may be fixed within optic fiber housing  175 , e.g., by a press fit, a setscrew, etc. Illustratively, a portion of optic fiber  310  may be fixed to actuation mechanism  110  and a portion of optic fiber  310  may be fixed to flexible housing tube  300 . 
     In one or more embodiments, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide proximal end  212  and away from actuation control guide distal end  211 , may be configured to retract actuation mechanism  110  relative to flexible housing tube  300 . Illustratively, a retraction of actuation mechanism  110  relative to flexible housing tube  300  may be configured to retract optic fiber housing  175  relative to flexible housing tube  300 . In one or more embodiments, a retraction of optic fiber housing  175  relative to flexible housing tube  300  may be configured to retract optic fiber  310  relative to flexible housing tube  300 . Illustratively, a portion of optic fiber  310  may be configured to resist a retraction of optic fiber  310  relative to flexible housing tube  300 , e.g., a portion of optic fiber  310  fixed to flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 . In one or more embodiments, an application of a force, e.g., a compressive force, to a portion of flexible housing tube  300  may be configured to compress a portion of flexible housing tube  300  causing flexible housing tube  300  to gradually curve. Illustratively, a gradual curving of flexible housing tube  300  may be configured to gradually curve optic fiber  310 . In one or more embodiments, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide proximal end  212  and away from actuation control guide distal end  211 , may be configured to gradually curve optic fiber  310 . For example, an actuation of an actuation control  120  of a plurality of actuation controls  120 , e.g., towards handle proximal end  202  and away from handle distal end  201 , may be configured to gradually curve optic fiber  310 . 
     In one or more embodiments, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide distal end  211  and away from actuation control guide proximal end  212 , may be configured to extend actuation mechanism  110  relative to flexible housing tube  300 . Illustratively, an extension of actuation mechanism  110  relative to flexible housing tube  300  may be configured to extend optic fiber housing  175  relative to flexible housing tube  300 . In one or more embodiments, an extension of optic fiber housing  175  relative to flexible housing tube  300  may be configured to extend optic fiber  310  relative to flexible housing tube  300 . Illustratively, a portion of optic fiber  310  may be configured to facilitate an extension of optic fiber  310  relative to flexible housing tube  300 , e.g., a portion of optic fiber  310  fixed to flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 . In one or more embodiments, a reduction of a force, e.g., a compressive force, applied to a portion of flexible housing tube  300  may be configured to decompress a portion of flexible housing tube  300  causing flexible housing tube  300  to gradually straighten. Illustratively, a gradual straightening of flexible housing tube  300  may be configured to gradually straighten optic fiber  310 . In one or more embodiments, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide distal end  211  and away from actuation control guide proximal end  212 , may be configured to gradually straighten optic fiber  310 . For example, an actuation of an actuation control  120  of a plurality of actuation controls  120 , e.g., towards handle distal end  201  and away from handle proximal end  202 , may be configured to gradually straighten optic fiber  310 . 
       FIGS. 5A, 5B, 5C, 5D, and 5E  are schematic diagrams illustrating a gradual curving of an optic fiber  310 .  FIG. 5A  illustrates a straight optic fiber  500 . In one or more embodiments, optic fiber  310  may comprise a straight optic fiber  500 , e.g., when optic fiber  310  is fully extended relative to flexible housing tube  300 . Illustratively, optic fiber  310  may comprise a straight optic fiber  500 , e.g., when an actuation control  120  of a plurality of actuation controls  120  is fully extended relative to an actuation control guide proximal end  212 . In one or more embodiments, optic fiber  310  may comprise a straight optic fiber  500 , e.g., when actuation mechanism  110  is fully extended relative to handle proximal end  202 . Illustratively, a line tangent to optic fiber distal end  311  may be parallel to a line tangent to flexible housing tube proximal end  302 , e.g., when optic fiber  310  comprises a straight optic fiber  500 . 
       FIG. 5B  illustrates an optic fiber in a first curved position  510 . In one or more embodiments, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide proximal end  212  and away from actuation control guide distal end  211 , may be configured to gradually curve optic fiber  310  from a straight optic fiber  500  to an optic fiber in a first curved position  510 . Illustratively, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide proximal end  212  and away from actuation control guide distal end  211 , may be configured to retract actuation mechanism  110  relative to flexible housing tube  300 . In one or more embodiments, a retraction of actuation mechanism  110  relative to flexible housing tube  300  may be configured to retract optic fiber  310  relative to flexible housing tube  300 . Illustratively, a retraction of optic fiber  310  relative to flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 , e.g., a portion of optic fiber  310  fixed to a portion of flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 . In one or more embodiments, an application of a force, e.g., a compressive force, to a portion of flexible housing tube  300  may be configured to compress a portion of flexible housing tube  300 . Illustratively, a compression of a portion of flexible housing tube  300  may be configured to gradually curve flexible housing tube  300 . In one or more embodiments, a gradual curving of flexible housing tube  300  may be configured to gradually curve optic fiber  310 , e.g., from a straight optic fiber  500  to an optic fiber in a first curved position  510 . Illustratively, a line tangent to optic fiber distal end  311  may intersect a line tangent to flexible housing tube proximal end  302  at a first angle, e.g., when optic fiber  310  comprises an optic fiber in a first curved position  510 . In one or more embodiments, the first angle may comprise any angle greater than zero degrees. For example, the first angle may comprise a 45 degree angle. 
       FIG. 5C  illustrates an optic fiber in a second curved position  520 . In one or more embodiments, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide proximal end  212  and away from actuation control guide distal end  211 , may be configured to gradually curve optic fiber  310  from an optic fiber in a first curved position  510  to an optic fiber in a second curved position  520 . Illustratively, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide proximal end  212  and away from actuation control guide distal end  211 , may be configured to retract actuation mechanism  110  relative to flexible housing tube  300 . In one or more embodiments, a retraction of actuation mechanism  110  relative to flexible housing tube  300  may be configured to retract optic fiber  310  relative to flexible housing tube  300 . Illustratively, a retraction of optic fiber  310  relative to flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 , e.g., a portion of optic fiber  310  fixed to a portion of flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 . In one or more embodiments, an application of a force, e.g., a compressive force, to a portion of flexible housing tube  300  may be configured to compress a portion of flexible housing tube  300 . Illustratively, a compression of a portion of flexible housing tube  300  may be configured to gradually curve flexible housing tube  300 . In one or more embodiments, a gradual curving of flexible housing tube  300  may be configured to gradually curve optic fiber  310 , e.g., from an optic fiber in a first curved position  510  to an optic fiber in a second curved position  520 . Illustratively, a line tangent to optic fiber distal end  311  may intersect a line tangent to flexible housing tube proximal end  302  at a second angle, e.g., when optic fiber  310  comprises an optic fiber in a second curved position  520 . In one or more embodiments, the second angle may comprise any angle greater than the first angle. For example, the second angle may comprise a 90 degree angle. 
       FIG. 5D  illustrates an optic fiber in a third curved position  530 . In one or more embodiments, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide proximal end  212  and away from actuation control guide distal end  211 , may be configured to gradually curve optic fiber  310  from an optic fiber in a second curved position  520  to an optic fiber in a third curved position  530 . Illustratively, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide proximal end  212  and away from actuation control guide distal end  211 , may be configured to retract actuation mechanism  110  relative to flexible housing tube  300 . In one or more embodiments, a retraction of actuation mechanism  110  relative to flexible housing tube  300  may be configured to retract optic fiber  310  relative to flexible housing tube  300 . Illustratively, a retraction of optic fiber  310  relative to flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 , e.g., a portion of optic fiber  310  fixed to a portion of flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 . In one or more embodiments, an application of a force, e.g., a compressive force, to a portion of flexible housing tube  300  may be configured to compress a portion of flexible housing tube  300 . Illustratively, a compression of a portion of flexible housing tube  300  may be configured to gradually curve flexible housing tube  300 . In one or more embodiments, a gradual curving of flexible housing tube  300  may be configured to gradually curve optic fiber  310 , e.g., from an optic fiber in a second curved position  520  to an optic fiber in a third curved position  530 . Illustratively, a line tangent to optic fiber distal end  311  may intersect a line tangent to flexible housing tube proximal end  302  at a third angle, e.g., when optic fiber  310  comprises an optic fiber in a third curved position  530 . In one or more embodiments, the third angle may comprise any angle greater than the second angle. For example, the third angle may comprise a 135 degree angle. 
       FIG. 5E  illustrates an optic fiber in a fourth curved position  540 . In one or more embodiments, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide proximal end  212  and away from actuation control guide distal end  211 , may be configured to gradually curve optic fiber  310  from an optic fiber in a third curved position  530  to an optic fiber in a fourth curved position  540 . Illustratively, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide proximal end  212  and away from actuation control guide distal end  211 , may be configured to retract actuation mechanism  110  relative to flexible housing tube  300 . In one or more embodiments, a retraction of actuation mechanism  110  relative to flexible housing tube  300  may be configured to retract optic fiber  310  relative to flexible housing tube  300 . Illustratively, a retraction of optic fiber  310  relative to flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 , e.g., a portion of optic fiber  310  fixed to a portion of flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 . In one or more embodiments, an application of a force, e.g., a compressive force, to a portion of flexible housing tube  300  may be configured to compress a portion of flexible housing tube  300 . Illustratively, a compression of a portion of flexible housing tube  300  may be configured to gradually curve flexible housing tube  300 . In one or more embodiments, a gradual curving of flexible housing tube  300  may be configured to gradually curve optic fiber  310 , e.g., from an optic fiber in a third curved position  530  to an optic fiber in a fourth curved position  540 . Illustratively, a line tangent to optic fiber distal end  311  may be parallel to a line tangent to flexible housing tube proximal end  302 , e.g., when optic fiber  310  comprises an optic fiber in a fourth curved position  540 . 
     In one or more embodiments, one or more properties of a steerable laser probe may be adjusted to attain one or more desired steerable laser probe features. Illustratively, a length that flexible housing tube distal end  301  extends from handle distal end  201  may be adjusted to vary an amount of actuation of an actuation control  120  of a plurality of actuation controls  120  configured to curve flexible housing tube  300  to a particular curved position. In one or more embodiments, a stiffness of flexible housing tube  300  may be adjusted to vary an amount of actuation of an actuation control  120  of a plurality of actuation controls  120  configured to curve flexible housing tube  300  to a particular curved position. Illustratively, flexible housing tube  300  may comprise a solid tube structure. In one or more embodiments, flexible housing tube  300  may comprise one or more apertures, e.g., configured to vary a stiffness of flexible housing tube  300 . Illustratively, a material comprising flexible housing tube  300  may be adjusted to vary an amount of actuation of an actuation control  120  of a plurality of actuation controls  120  configured to curve flexible housing tube  300  to a particular curved position. In one or more embodiments, a stiffness of flexible housing tube  300  may be adjusted to vary a bend radius of flexible housing tube  300 . Illustratively, a stiffness of flexible housing tube  300  may be adjusted to vary a radius of curvature of flexible housing tube  300 , e.g., when flexible housing tube  300  is in a particular curved position. 
     In one or more embodiments, a geometry of actuation mechanism  110  may be adjusted to vary an amount of actuation of an actuation control  120  of a plurality of actuation controls  120  configured to curve flexible housing tube  300  to a particular curved position. Illustratively, a geometry of actuation mechanism guide  180  may be adjusted to vary an amount of actuation of an actuation control  120  of a plurality of actuation controls  120  configured to curve flexible housing tube  300  to a particular curved position. In one or more embodiments, a geometry of handle end cap  105  or a geometry of handle base  130  may be adjusted to vary an amount of actuation of an actuation control  120  of a plurality of actuation controls  120  configured to curve flexible housing tube  300  to a particular curved position. Illustratively, one or more locations within flexible housing tube  300  wherein optic fiber  310  may be fixed to a portion of flexible housing tube  300  may be adjusted to vary an amount of actuation of an actuation control  120  of a plurality of actuation controls  120  configured to curve flexible housing tube  300  to a particular curved position. 
     In one or more embodiments, at least a portion of optic fiber  310  may be enclosed in an optic fiber sleeve configured to, e.g., protect optic fiber  310 , vary a stiffness of optic fiber  310 , vary an optical property of optic fiber  310 , etc. Illustratively, an optic fiber sleeve may be configured to compress a portion of flexible housing tube  300 . For example, an optic fiber sleeve may enclose a portion of optic fiber  310  and the optic fiber sleeve may be fixed to actuation mechanism  110 , e.g., the optic fiber sleeve may be fixed within optic fiber housing  175  by an adhesive or any suitable fixation means. Illustratively, a portion of the optic fiber sleeve may be fixed to a portion of flexible housing tube  300 , e.g., by an adhesive or any suitable fixation means. In one or more embodiments, an actuation of an actuation control  120  of a plurality of actuation controls  120  may be configured to retract an optic fiber sleeve relative to flexible housing tube  300 . Illustratively, a retraction of an optic fiber sleeve relative to flexible housing tube  300  may be configured to cause the optic fiber sleeve to apply a force, e.g., a compressive force, to a portion of flexible housing tube  300  causing flexible housing tube  300  to gradually curve. In one or more embodiments, a gradual curving of flexible housing tube  300  may be configured to gradually curve optic fiber  310 . 
     Illustratively, optic fiber  310  may comprise a buffer, a cladding disposed in the buffer, and a core disposed in the cladding. In one or more embodiments, at least a portion of optic fiber  310  may comprise a buffer configured to protect an optical property of optic fiber  310 . Illustratively, at least a portion of optic fiber  310  may comprise a buffer configured to protect an optical layer of optic fiber  310 , e.g., the buffer may protect an optical layer of a curved portion of optic fiber  310 . In one or more embodiments, at least a portion of optic fiber  310  may comprise a polyimide buffer configured to protect an optical property of optic fiber  310 . For example, at least a portion of optic fiber  310  may comprise a Kapton buffer configured to protect an optical property of optic fiber  310 . 
     Illustratively, a steerable laser probe may be configured to indicate, e.g., to a surgeon, a direction that optic fiber  310  may curve, e.g., due to an actuation of an actuation control  120  of a plurality of actuation controls  120 . In one or more embodiments, a portion of a steerable laser probe, e.g., handle  200 , may be marked in a manner configured to indicate a direction that optic fiber  310  may curve. For example, a portion of flexible housing tube  300  may comprise a mark configured to indicate a direction that optic fiber  310  may curve. Illustratively, flexible housing tube  300  may comprise a slight curve, e.g., a curve less than 7.5 degrees, when an actuation control  120  of a plurality of actuation controls  120  is fully extended relative to an actuation control guide proximal end  212 . In one or more embodiments, flexible housing tube  300  may comprise a slight curve configured to indicate a direction that optic fiber  310  may curve, e.g., due to a retraction of an actuation control  120  of a plurality of actuation controls  120  relative to an actuation control guide proximal end  212 . 
     In one or more embodiments, a steerable laser probe may comprise a pressure mechanism configured to provide a force. Illustratively, a pressure mechanism may be disposed within pressure mechanism housing  185 . For example, a pressure mechanism may be disposed within proximal chamber  140 . In one or more embodiments, a pressure mechanism may be configured to provide a constant force. Illustratively, a pressure mechanism may be configured to provide a variable force. In one or more embodiments, a pressure mechanism may be configured to provide a resistive force, e.g., to resist an extension of actuation mechanism  110  relative to handle proximal end  202 . Illustratively, a pressure mechanism may be configured to provide a facilitating force, e.g., to facilitate a retraction of actuation mechanism  110  relative to handle proximal end  202 . In one or more embodiments, a pressure mechanism may be configured to provide a resistive force, e.g., to resist a retraction of actuation mechanism  110  relative to handle proximal end  202 . Illustratively, a pressure mechanism may be configured to provide a facilitating force, e.g., to facilitate an extension of actuation mechanism  110  relative to handle proximal end  202 . In one or more embodiments, a pressure mechanism may comprise a spring or a coil. Illustratively, a pressure mechanism may comprise a pneumatic system or any system configured to provide a force. 
     In one or more embodiments, one or more actuation controls  120  may be fixed together. For example, a first actuation control  120  may be connected to a second actuation control  120  wherein an actuation of the first actuation control  120  is configured to actuate the second actuation control  120  and an actuation of the second actuation control  120  is configured to actuate the first actuation control  120 . Illustratively, each actuation control  120  of a plurality of actuation controls  120  may be connected wherein an actuation of a particular actuation control  120  is configured to actuate each actuation control  120  of the plurality of actuation controls  120 . In one or more embodiments, each actuation control  120  may be connected to another actuation control  120  of a plurality of actuation controls  120 , e.g., by a ring or any suitable structure wherein a surgeon may actuate each actuation control  120  of the plurality of actuation controls  120  in any rotational orientation of handle  200 . 
     Illustratively, handle  200  may comprise one or more detents configured to temporarily house an actuation control  120  of a plurality of actuation controls  120 . In one or more embodiments, an actuation control guide  210  may comprise one or more detents configured to temporarily fix an actuation control  120  in a position relative to handle proximal end  202 . Illustratively, a surgeon may actuate an actuation control  120  of a plurality of actuation controls  120  into a detent of an actuation control guide  210 , e.g., to temporarily fix an actuation control  120  in a position relative to handle proximal end  202 . In one or more embodiments, temporarily fixing an actuation control  120  of a plurality of actuation controls  120  in a position relative to handle proximal end  202  may be configured to temporarily fix flexible housing tube  300  in a particular curved position. Illustratively, a surgeon may actuate an actuation control  120  out from a detent of an actuation control guide  210 , e.g., to adjust an amount of actuation of an actuation control  120  relative to handle proximal end  202 . In one or more embodiments, adjusting an amount of actuation of an actuation control  120  relative to handle proximal end  202  may be configured to adjust a curvature of flexible housing tube  300 . 
       FIGS. 6A, 6B, 6C, 6D, and 6E  are schematic diagrams illustrating a gradual straightening of an optic fiber  310 .  FIG. 6A  illustrates a fully curved optic fiber  600 . In one or more embodiments, optic fiber  310  may comprise a fully curved optic fiber  600 , e.g., when optic fiber  310  is fully retracted relative to flexible housing tube  300 . Illustratively, optic fiber  310  may comprise a fully curved optic fiber  600 , e.g., when an actuation control  120  of a plurality of actuation controls  120  is fully retracted relative to an actuation control guide proximal end  212 . In one or more embodiments, optic fiber  310  may comprise a fully curved optic fiber  600 , e.g., when actuation mechanism  110  is fully retracted relative to handle proximal end  202 . Illustratively, a line tangent to optic fiber distal end  311  may be parallel to a line tangent to flexible housing tube proximal end  302 , e.g., when optic fiber  310  comprises a fully curved optic fiber  600 . 
       FIG. 6B  illustrates an optic fiber in a first partially straightened position  610 . In one or more embodiments, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide distal end  211  and away from actuation control guide proximal end  212 , may be configured to gradually straighten optic fiber  310  from a fully curved optic fiber  600  to an optic fiber in a first partially straightened position  610 . Illustratively, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide distal end  211  and away from actuation control guide proximal end  212 , may be configured to extend actuation mechanism  110  relative to flexible housing tube  300 . In one or more embodiments, an extension of actuation mechanism  110  relative to flexible housing tube  300  may be configured to extend optic fiber  310  relative to flexible housing tube  300 . Illustratively, an extension of optic fiber  310  relative to flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 , e.g., a portion of optic fiber  310  fixed to a portion of flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 . In one or more embodiments, a reduction of a force, e.g., a compressive force, applied to a portion of flexible housing tube  300  may be configured to decompress a portion of flexible housing tube  300 . Illustratively, a decompression of a portion of flexible housing tube  300  may be configured to gradually straighten flexible housing tube  300 . In one or more embodiments, a gradual straightening of flexible housing tube  300  may be configured to gradually straighten optic fiber  310 , e.g., from a fully curved optic fiber  600  to an optic fiber in a first partially straightened position  610 . In one or more embodiments, a line tangent to optic fiber distal end  311  may intersect a line tangent to flexible housing tube proximal end  302  at a first partially straightened angle, e.g., when optic fiber  310  comprises an optic fiber in a first partially straightened position  610 . Illustratively, the first partially straightened angle may comprise any angle less than 180 degrees. For example, the first partially straightened angle may comprise a 135 degree angle. 
       FIG. 6C  illustrates an optic fiber in a second partially straightened position  620 . In one or more embodiments, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide distal end  211  and away from actuation control guide proximal end  212 , may be configured to gradually straighten optic fiber  310  from an optic fiber in a first partially straightened position  610  to an optic fiber in a second partially straightened position  620 . Illustratively, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide distal end  211  and away from actuation control guide proximal end  212 , may be configured to extend actuation mechanism  110  relative to flexible housing tube  300 . In one or more embodiments, an extension of actuation mechanism  110  relative to flexible housing tube  300  may be configured to extend optic fiber  310  relative to flexible housing tube  300 . Illustratively, an extension of optic fiber  310  relative to flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 , e.g., a portion of optic fiber  310  fixed to a portion of flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 . In one or more embodiments, a reduction of a force, e.g., a compressive force, applied to a portion of flexible housing tube  300  may be configured to decompress a portion of flexible housing tube  300 . Illustratively, a decompression of a portion of flexible housing tube  300  may be configured to gradually straighten flexible housing tube  300 . In one or more embodiments, a gradual straightening of flexible housing tube  300  may be configured to gradually straighten optic fiber  310 , e.g., from an optic fiber in a first partially straightened position  610  to an optic fiber in a second partially straightened position  620 . In one or more embodiments, a line tangent to optic fiber distal end  311  may intersect a line tangent to flexible housing tube proximal end  302  at a second partially straightened angle, e.g., when optic fiber  310  comprises an optic fiber in a second partially straightened position  620 . Illustratively, the second partially straightened angle may comprise any angle less than the first partially straightened angle. For example, the second partially straightened angle may comprise a 90 degree angle. 
       FIG. 6D  illustrates an optic fiber in a third partially straightened position  630 . In one or more embodiments, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide distal end  211  and away from actuation control guide proximal end  212 , may be configured to gradually straighten optic fiber  310  from an optic fiber in a second partially straightened position  620  to an optic fiber in a third partially straightened position  630 . Illustratively, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide distal end  211  and away from actuation control guide proximal end  212 , may be configured to extend actuation mechanism  110  relative to flexible housing tube  300 . In one or more embodiments, an extension of actuation mechanism  110  relative to flexible housing tube  300  may be configured to extend optic fiber  310  relative to flexible housing tube  300 . Illustratively, an extension of optic fiber  310  relative to flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 , e.g., a portion of optic fiber  310  fixed to a portion of flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 . In one or more embodiments, a reduction of a force, e.g., a compressive force, applied to a portion of flexible housing tube  300  may be configured to decompress a portion of flexible housing tube  300 . 
     Illustratively, a decompression of a portion of flexible housing tube  300  may be configured to gradually straighten flexible housing tube  300 . In one or more embodiments, a gradual straightening of flexible housing tube  300  may be configured to gradually straighten optic fiber  310 , e.g., from an optic fiber in a second partially straightened position  620  to an optic fiber in a third partially straightened position  630 . In one or more embodiments, a line tangent to optic fiber distal end  311  may intersect a line tangent to flexible housing tube proximal end  302  at a third partially straightened angle, e.g., when optic fiber  310  comprises an optic fiber in a third partially straightened position  630 . Illustratively, the third partially straightened angle may comprise any angle less than the second partially straightened angle. For example, the third partially straightened angle may comprise a 45 degree angle. 
       FIG. 6E  illustrates an optic fiber in a fully straightened position  640 . In one or more embodiments, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide distal end  211  and away from actuation control guide proximal end  212 , may be configured to gradually straighten optic fiber  310  from an optic fiber in a third partially straightened position  630  to an optic fiber in a fully straightened position  640 . Illustratively, an actuation of an actuation control  120  within an actuation control guide  210 , e.g., towards actuation control guide distal end  211  and away from actuation control guide proximal end  212 , may be configured to extend actuation mechanism  110  relative to flexible housing tube  300 . In one or more embodiments, an extension of actuation mechanism  110  relative to flexible housing tube  300  may be configured to extend optic fiber  310  relative to flexible housing tube  300 . Illustratively, an extension of optic fiber  310  relative to flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 , e.g., a portion of optic fiber  310  fixed to a portion of flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 . In one or more embodiments, a reduction of a force, e.g., a compressive force, applied to a portion of flexible housing tube  300  may be configured to decompress a portion of flexible housing tube  300 . Illustratively, a decompression of a portion of flexible housing tube  300  may be configured to gradually straighten flexible housing tube  300 . In one or more embodiments, a gradual straightening of flexible housing tube  300  may be configured to gradually straighten optic fiber  310 , e.g., from an optic fiber in a third partially straightened position  630  to an optic fiber in a fully straightened position  640 . In one or more embodiments, a line tangent to optic fiber distal end  311  may be parallel to a line tangent to flexible housing tube proximal end  302 , e.g., when optic fiber  310  comprises an optic fiber in a fully straightened position  640 . 
     Illustratively, a surgeon may aim optic fiber distal end  311  at any of a plurality of targets within an eye, e.g., to perform a photocoagulation procedure, to illuminate a surgical target site, etc. In one or more embodiments, a surgeon may aim optic fiber distal end  311  at any target within a particular transverse plane of the inner eye by, e.g., rotating handle  200  to orient flexible housing tube  300  in an orientation configured to cause a curvature of flexible housing tube  300  within the particular transverse plane of the inner eye and varying an amount of actuation of an actuation control  120  of a plurality of actuation controls  120 . Illustratively, a surgeon may aim optic fiber distal end  311  at any target within a particular sagittal plane of the inner eye by, e.g., rotating handle  200  to orient flexible housing tube  300  in an orientation configured to cause a curvature of flexible housing tube  300  within the particular sagittal plane of the inner eye and varying an amount of actuation of an actuation control  120  of a plurality of actuation controls  120 . In one or more embodiments, a surgeon may aim optic fiber distal end  311  at any target within a particular frontal plane of the inner eye by, e.g., varying an amount of actuation of an actuation control  120  of a plurality of actuation controls  120  to orient a line tangent to optic fiber distal end  311  wherein the line tangent to optic fiber distal end  311  is within the particular frontal plane of the inner eye and rotating handle  200 . Illustratively, a surgeon may aim optic fiber distal end  311  at any target located outside of the particular transverse plane, the particular sagittal plane, and the particular frontal plane of the inner eye, e.g., by varying a rotational orientation of handle  200  and varying an amount of actuation of an actuation control  120  of a plurality of actuation controls  120 . In one or more embodiments, a surgeon may aim optic fiber distal end  311  at any target of a plurality of targets within an eye, e.g., without increasing a length of a portion of a steerable laser probe within the eye. Illustratively, a surgeon may aim optic fiber distal end  311  at any target of a plurality of targets within an eye, e.g., without decreasing a length of a portion of a steerable laser probe within the eye. 
       FIGS. 7A and 7B  are schematic diagrams illustrating an exploded view of a handle assembly  700 .  FIG. 7A  illustrates a side view of handle assembly  700 . In one or more embodiments, handle assembly  700  may comprise a handle end cap  705  having a handle end cap distal end  706  and a handle end cap proximal end  707 , an actuation mechanism  710  having an actuation mechanism distal end  711  and an actuation mechanism proximal end  712 , and a handle base  730  having a handle base distal end  731  and a handle base proximal end  732 . Illustratively, actuation mechanism  710  may comprise a plurality of actuation controls  720 . For example, each actuation control  720  of a plurality of actuation controls  720  may comprise an actuation control distal end  721  and an actuation control proximal end  722 . In one or more embodiments, handle base  730  may comprise a plurality of handle base limbs  733 , a plurality of handle base channels  734 , and a handle end cap interface  735 . 
       FIG. 7B  illustrates a cross-sectional view of handle assembly  700 . In one or more embodiments, handle assembly  700  may comprise a proximal chamber  740 , a handle base housing  750 , a handle base interface  755 , an optic fiber guide  760 , an inner bore  770 , cable housing  775 , an actuation mechanism guide  780 , a pressure mechanism housing  785 , and a housing tube housing  790 . Handle end cap  705 , actuation mechanism  710 , actuation control  720 , and handle base  730  may be manufactured from any suitable material, e.g., polymers, metals, metal alloys, etc., or from any combination of suitable materials. 
       FIGS. 8A and 8B  are schematic diagrams illustrating a handle  800 .  FIG. 8A  illustrates a side view of handle  800 . In one or more embodiments, handle  800  may comprise a handle distal end  801 , a handle proximal end  802 , and a plurality of actuation control guides  810 . For example, each actuation control guide  810  of a plurality of actuation control guides  810  may comprise an actuation control guide distal end  811  and an actuation control guide proximal end  812 . Illustratively, handle distal end  801  may comprise handle base distal end  731 . In one or more embodiments, handle proximal end  802  may comprise handle end cap proximal end  707 . 
       FIG. 8B  illustrates a cross-sectional view of handle  800 . Illustratively, actuation mechanism  710  may be disposed within handle end cap  705  and handle base  730 . In one or more embodiments, a portion of actuation mechanism  710  may be disposed within handle base housing  750 , e.g., actuation mechanism proximal end  712  may be disposed within handle base housing  750 . Illustratively, a portion of actuation mechanism  710  may be disposed within actuation mechanism guide  780 , e.g., actuation mechanism distal end  711  may be disposed within actuation mechanism guide  780 . In one or more embodiments, a portion of handle base  730  may be disposed within handle end cap  705 , e.g., handle base proximal end  732  may be disposed within handle end cap  705 . Illustratively, a portion of handle base  730  may be disposed within handle base housing  750 . In one or more embodiments, a portion of handle base  730  may be disposed within handle base housing  750 , e.g., handle base proximal end  732  may be configured to interface with handle base interface  755 . Illustratively, a portion of handle base  730  may be disposed within handle base housing  750 , e.g., handle end cap distal end  706  may be configured to interface with handle end cap interface  735 . In one or more embodiments, a portion of handle base  730  may be fixed within a portion of handle end cap  705 , e.g., by an adhesive or any suitable fixation means. For example, a portion of handle base  730  may be fixed within handle base housing  750 , e.g., by an adhesive or any suitable fixation means. 
     Illustratively, each actuation control  720  of a plurality of actuation controls  720  may be disposed within an actuation control guide  810  of a plurality of actuation control guides  810 . In one or more embodiments, each actuation control guide  810  of a plurality of actuation control guides  810  may comprise a handle base channel  734  of a plurality of handle base channels  734 . In one or more embodiments, at least one actuation control  720  may be configured to actuate within at least one actuation control guide  810 . Illustratively, each actuation control  720  of a plurality of actuation controls  720  may be configured to actuate within an actuation control guide  810  of a plurality of actuation control guides  810 . In one or more embodiments, an actuation of a particular actuation control  720  in a particular actuation control guide  810  may be configured to actuate each actuation control  720  of a plurality of actuation controls  720 . In one or more embodiments, actuation controls  720  may be configured to actuate within actuation control guides  810  in pairs or groups. Illustratively, an actuation of first actuation control  720  within a first actuation control guide  810  may be configured to actuate a second actuation control  720  within a second actuation control guide  810 . 
     In one or more embodiments, actuation mechanism  710  may be configured to actuate within actuation mechanism guide  780 . For example, actuation mechanism guide  780  may comprise a lubricant configured to facilitate an actuation of actuation mechanism  710  within actuation mechanism guide  780 . Illustratively, an actuation of an actuation control  720  within an actuation control guide  810  may be configured to actuate actuation mechanism  710 , e.g., within actuation mechanism guide  780 . In one or more embodiments, an actuation of an actuation control  720  towards an actuation control guide distal end  811 , e.g., and away from an actuation control guide proximal end  812 , may be configured to actuate actuation mechanism  710  towards handle distal end  801 , e.g., and away from handle proximal end  802 . Illustratively, an actuation of an actuation control  720  towards an actuation control guide proximal end  812 , e.g., and away from an actuation control guide distal end  811 , may be configured to actuate actuation mechanism towards handle proximal end  802 , e.g., and away from handle distal end  801 . 
     In one or more embodiments, a surgeon may actuate actuation mechanism  710  within actuation mechanism guide  780 , e.g., by manipulating an actuation control  720  of a plurality of actuation controls  720  when handle  800  is in a first rotational orientation. Illustratively, the surgeon may rotate handle  800  and actuate actuation mechanism  710  within actuation mechanism guide  780 , e.g., by manipulating an actuation control  720  of a plurality of actuation controls  720  when handle  800  is in a second rotational orientation. In one or more embodiments, the surgeon may rotate handle  800  and actuate actuation mechanism  710  within actuation mechanism guide  780 , e.g., by manipulating an actuation control  720  of a plurality of actuation controls  720  when handle  800  is in a third rotational orientation. Illustratively, a surgeon may actuate actuation mechanism  710  within actuation mechanism guide  780 , e.g., by manipulating an actuation control  720  of a plurality of actuation controls  720  when handle  800  is in any rotational orientation of a plurality of rotational orientations. 
       FIG. 9  is a schematic diagram illustrating a flexible housing tube  300 . Illustratively, flexible housing tube  300  may comprise a flexible housing tube distal end  301  and a flexible housing tube proximal end  302 . Flexible housing tube  300  may be manufactured from any suitable material, e.g., polymers, metals, metal alloys, etc., or from any combination of suitable materials. Illustratively, flexible housing tube  300  may comprise a shape memory material, e.g., Nitinol. In one or more embodiments, flexible housing tube  300  may be manufactured from a material having an ultimate tensile strength between 700 and 1000 MPa. Illustratively, flexible housing tube  300  may be manufactured from a material having ultimate tensile strength less than 700 MPa or greater than 1000 MPa. In one or more embodiments, flexible housing tube  300  may be manufactured from a material having a modulus of elasticity between 30 and 80 GPa. Illustratively, flexible housing tube  300  may be manufactured from a material having a modulus of elasticity less than 30 GPa or greater than 80 GPa. 
     In one or more embodiments, flexible housing tube  300  may be manufactured with dimensions suitable for performing microsurgical procedures, e.g., ophthalmic surgical procedures. Illustratively, flexible housing tube  300  may be manufactured at gauge sizes commonly used in ophthalmic surgical procedures, e.g., 23 gauge, 25 gauge, etc. In one or more embodiments, flexible housing tube  300  may be configured to be inserted in a cannula, e.g., a cannula used during an ophthalmic surgical procedure. For example, one or more properties of flexible housing tube  300  may be optimized to reduce friction as flexible housing tube  300  is inserted into a cannula. In one or more embodiments, one or more properties of flexible housing tube  300  may be optimized to reduce friction as flexible housing tube  300  is removed from a cannula. Illustratively, flexible housing tube  300  may have an ultimate tensile strength between 1000 MPa and 1100 MPa. In one or more embodiments, flexible housing tube  300  may have an ultimate tensile strength less than 1000 MPa or greater than 1100 MPa. 
     In one or more embodiments, an optic fiber  310  may be disposed within flexible housing tube  300 . Illustratively, optic fiber  310  may comprise an optic fiber distal end  311  and an optic fiber proximal end  312 . In one or more embodiments, optic fiber  310  may be configured to transmit light, e.g., laser light. Illustratively, optic fiber  310  may be disposed within flexible housing tube  300  wherein optic fiber distal end  311  may be adjacent to flexible housing tube distal end  301 . In one or more embodiments, a portion of optic fiber  310  may be fixed to a portion of flexible housing tube  300 , e.g., by an adhesive or any suitable fixation means. 
     In one or more embodiments, a cable  910  may be disposed within flexible housing tube  300 . Illustratively, cable  910  may comprise a cable distal end  911  and a cable proximal end  912 . In one or more embodiments, cable  910  may be disposed within flexible housing tube  300  wherein cable distal end  911  may be adjacent to flexible housing tube distal end  301 . Illustratively, a portion of cable  910  may be fixed to a portion of flexible housing tube  300 , e.g., by an adhesive or any suitable fixation means. 
       FIG. 10  is a schematic diagram illustrating an exploded view of a steerable laser probe assembly  1000 . In one or more embodiments, steerable laser probe assembly  1000  may comprise a handle  800 , a flexible housing tube  300  having a flexible housing tube distal end  301  and a flexible housing tube proximal end  302 , an optic fiber  310  having an optic fiber distal end  311  and an optic fiber proximal end  312 , a cable  910  having a cable distal end  911  and a cable proximal end  912 , and a light source interface  410 . Illustratively, light source interface  410  may be configured to interface with optic fiber  310 , e.g., at optic fiber proximal end  312 . In one or more embodiments, light source interface  410  may comprise a standard light source connecter, e.g., an SMA connector. 
     Illustratively, a portion of flexible housing tube  300  may be fixed to a portion of handle  800 , e.g., flexible housing tube proximal end  302  may be fixed to handle distal end  801 . In one or more embodiments, a portion of flexible housing tube  300  may be fixed to a portion of handle  800 , e.g., by an adhesive or any suitable fixation means. Illustratively, a portion of flexible housing tube  300  may be disposed within flexible housing tube housing  790 , e.g., flexible housing tube proximal end  302  may be disposed within flexible housing tube housing  790 . In one or more embodiments, a portion of flexible housing tube  300  may be fixed within flexible housing tube housing  790 , e.g., by an adhesive or any suitable fixation means. For example, flexible housing tube  300  may be fixed within flexible housing tube housing  790  by a press fit, a setscrew, etc. 
     In one or more embodiments, optic fiber  310  may be disposed in optic fiber guide  760 , inner bore  770 , cable housing  775 , actuation mechanism guide  780 , flexible housing tube housing  790 , and flexible housing tube  300 . Illustratively, optic fiber  310  may be disposed within flexible housing tube  300  wherein optic fiber distal end  311  may be adjacent to flexible housing tube distal end  301 . In one or more embodiments, a portion of optic fiber  310  may be fixed to a portion of flexible housing tube  300 , e.g., by an adhesive or any suitable fixation means. 
     Illustratively, cable  910  may be disposed in cable housing  775 , actuation mechanism guide  780 , flexible housing tube housing  790 , and flexible housing tube  300 . In one or more embodiments, a portion of cable  910  may be fixed to a portion of flexible housing tube  300 , e.g., by an adhesive or any suitable fixation means. Illustratively, a portion of cable  910  may be fixed to a portion of actuation mechanism  710 , e.g., cable proximal end  912  may be fixed to a portion of actuation mechanism  710 . In one or more embodiments, a portion of cable  910  may be fixed within cable housing  775 , e.g., cable proximal end  912  may be fixed within cable housing  775 . Illustratively, a portion of cable  910  may be fixed within cable housing  775 , e.g., by an adhesive or any suitable fixation means. For example, a portion of cable  910  may be fixed within cable housing  775  by a press fit, a setscrew, etc. 
     In one or more embodiments, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide proximal end  812  and away from actuation control guide distal end  811 , may be configured to retract actuation mechanism  710  relative to flexible housing tube  300 . Illustratively, a retraction of actuation mechanism  710  relative to flexible housing tube  300  may be configured to retract cable housing  775  relative to flexible housing tube  300 . In one or more embodiments, a retraction of cable housing  775  relative to flexible housing tube  300  may be configured to retract cable  910  relative to flexible housing tube  300 . Illustratively, a portion of cable  910  may be configured to resist a retraction of cable  910  relative to flexible housing tube  300 , e.g., a portion of cable  910  fixed to flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 . In one or more embodiments, an application of a force, e.g., a compressive force, to a portion of flexible housing tube  300  may be configured to compress a portion of flexible housing tube  300  causing flexible housing tube  300  to gradually curve. Illustratively, a gradual curving of flexible housing tube  300  may be configured to gradually curve optic fiber  310 . In one or more embodiments, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide proximal end  812  and away from actuation control guide distal end  811 , may be configured to gradually curve optic fiber  310 . For example, an actuation of an actuation control  720  of a plurality of actuation controls  720 , e.g., towards handle proximal end  802  and away from handle distal end  801 , may be configured to gradually curve optic fiber  310 . 
     In one or more embodiments, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide distal end  811  and away from actuation control guide proximal end  812 , may be configured to extend actuation mechanism  710  relative to flexible housing tube  300 . Illustratively, an extension of actuation mechanism  710  relative to flexible housing tube  300  may be configured to extend cable housing  775  relative to flexible housing tube  300 . In one or more embodiments, an extension of cable housing  775  relative to flexible housing tube  300  may be configured to extend cable  910  relative to flexible housing tube  300 . Illustratively, a portion of cable  910  may be configured to facilitate an extension of cable  910  relative to flexible housing tube  300 , e.g., a portion of cable  910  fixed to flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 . In one or more embodiments, a reduction of a force, e.g., a compressive force, applied to a portion of flexible housing tube  300  may be configured to decompress a portion of flexible housing tube  300  causing flexible housing tube  300  to gradually straighten. Illustratively, a gradual straightening of flexible housing tube  300  may be configured to gradually straighten optic fiber  310 . In one or more embodiments, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide distal end  811  and away from actuation control guide proximal end  812 , may be configured to gradually straighten optic fiber  310 . For example, an actuation of an actuation control  720  of a plurality of actuation controls  720 , e.g., towards handle distal end  801  and away from handle proximal end  802 , may be configured to gradually straighten optic fiber  310 . 
       FIGS. 11A, 11B, 11C, 11D, and 11E  are schematic diagrams illustrating a gradual curving of an optic fiber  310 .  FIG. 11A  illustrates a straight optic fiber  1100 . In one or more embodiments, optic fiber  310  may comprise a straight optic fiber  1100 , e.g., when cable  910  is fully extended relative to flexible housing tube  300 . Illustratively, optic fiber  310  may comprise a straight optic fiber  1100 , e.g., when an actuation control  720  of a plurality of actuation controls  720  is fully extended relative to an actuation control guide proximal end  812 . In one or more embodiments, optic fiber  310  may comprise a straight optic fiber  1100 , e.g., when actuation mechanism  710  is fully extended relative to handle proximal end  802 . Illustratively, a line tangent to optic fiber distal end  311  may be parallel to a line tangent to flexible housing tube proximal end  302 , e.g., when optic fiber  310  comprises a straight optic fiber  1100 . 
       FIG. 11B  illustrates an optic fiber in a first curved position  1110 . In one or more embodiments, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide proximal end  812  and away from actuation control guide distal end  811 , may be configured to gradually curve optic fiber  310  from a straight optic fiber  1100  to an optic fiber in a first curved position  1110 . Illustratively, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide proximal end  812  and away from actuation control guide distal end  811 , may be configured to retract actuation mechanism  710  relative to flexible housing tube  300 . In one or more embodiments, a retraction of actuation mechanism  710  relative to flexible housing tube  300  may be configured to retract cable  910  relative to flexible housing tube  300 . Illustratively, a retraction of cable  910  relative to flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 , e.g., a portion of cable  910  fixed to a portion of flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 . In one or more embodiments, an application of a force, e.g., a compressive force, to a portion of flexible housing tube  300  may be configured to compress a portion of flexible housing tube  300 . Illustratively, a compression of a portion of flexible housing tube  300  may be configured to gradually curve flexible housing tube  300 . In one or more embodiments, a gradual curving of flexible housing tube  300  may be configured to gradually curve optic fiber  310 , e.g., from a straight optic fiber  1100  to an optic fiber in a first curved position  1110 . Illustratively, a line tangent to optic fiber distal end  311  may intersect a line tangent to flexible housing tube proximal end  302  at a first angle, e.g., when optic fiber  310  comprises an optic fiber in a first curved position  1110 . In one or more embodiments, the first angle may comprise any angle greater than zero degrees. For example, the first angle may comprise a 45 degree angle. 
       FIG. 11C  illustrates an optic fiber in a second curved position  1120 . In one or more embodiments, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide proximal end  812  and away from actuation control guide distal end  811 , may be configured to gradually curve optic fiber  310  from an optic fiber in a first curved position  1110  to an optic fiber in a second curved position  1120 . Illustratively, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide proximal end  812  and away from actuation control guide distal end  811 , may be configured to retract actuation mechanism  710  relative to flexible housing tube  300 . In one or more embodiments, a retraction of actuation mechanism  710  relative to flexible housing tube  300  may be configured to retract cable  910  relative to flexible housing tube  300 . Illustratively, a retraction of cable  910  relative to flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 , e.g., a portion of cable  910  fixed to a portion of flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 . In one or more embodiments, an application of a force, e.g., a compressive force, to a portion of flexible housing tube  300  may be configured to compress a portion of flexible housing tube  300 . Illustratively, a compression of a portion of flexible housing tube  300  may be configured to gradually curve flexible housing tube  300 . In one or more embodiments, a gradual curving of flexible housing tube  300  may be configured to gradually curve optic fiber  310 , e.g., from an optic fiber in a first curved position  1110  to an optic fiber in a second curved position  1120 . Illustratively, a line tangent to optic fiber distal end  311  may intersect a line tangent to flexible housing tube proximal end  302  at a second angle, e.g., when optic fiber  310  comprises an optic fiber in a second curved position  1120 . In one or more embodiments, the second angle may comprise any angle greater than the first angle. For example, the second angle may comprise a 90 degree angle. 
       FIG. 11D  illustrates an optic fiber in a third curved position  1130 . In one or more embodiments, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide proximal end  812  and away from actuation control guide distal end  811 , may be configured to gradually curve optic fiber  310  from an optic fiber in a second curved position  1120  to an optic fiber in a third curved position  1130 . Illustratively, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide proximal end  812  and away from actuation control guide distal end  811 , may be configured to retract actuation mechanism  710  relative to flexible housing tube  300 . In one or more embodiments, a retraction of actuation mechanism  710  relative to flexible housing tube  300  may be configured to retract cable  910  relative to flexible housing tube  300 . Illustratively, a retraction of cable  910  relative to flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 , e.g., a portion of cable  910  fixed to a portion of flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 . In one or more embodiments, an application of a force, e.g., a compressive force, to a portion of flexible housing tube  300  may be configured to compress a portion of flexible housing tube  300 . Illustratively, a compression of a portion of flexible housing tube  300  may be configured to gradually curve flexible housing tube  300 . In one or more embodiments, a gradual curving of flexible housing tube  300  may be configured to gradually curve optic fiber  310 , e.g., from an optic fiber in a second curved position  1120  to an optic fiber in a third curved position  1130 . Illustratively, a line tangent to optic fiber distal end  311  may intersect a line tangent to flexible housing tube proximal end  302  at a third angle, e.g., when optic fiber  310  comprises an optic fiber in a third curved position  1130 . In one or more embodiments, the third angle may comprise any angle greater than the second angle. For example, the third angle may comprise a 135 degree angle. 
       FIG. 11E  illustrates an optic fiber in a fourth curved position  1140 . In one or more embodiments, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide proximal end  812  and away from actuation control guide distal end  811 , may be configured to gradually curve optic fiber  310  from an optic fiber in a third curved position  1130  to an optic fiber in a fourth curved position  1140 . Illustratively, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide proximal end  812  and away from actuation control guide distal end  811 , may be configured to retract actuation mechanism  710  relative to flexible housing tube  300 . In one or more embodiments, a retraction of actuation mechanism  710  relative to flexible housing tube  300  may be configured to retract cable  910  relative to flexible housing tube  300 . Illustratively, a retraction of cable  910  relative to flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 , e.g., a portion of cable  910  fixed to a portion of flexible housing tube  300  may be configured to apply a force to a portion of flexible housing tube  300 . In one or more embodiments, an application of a force, e.g., a compressive force, to a portion of flexible housing tube  300  may be configured to compress a portion of flexible housing tube  300 . Illustratively, a compression of a portion of flexible housing tube  300  may be configured to gradually curve flexible housing tube  300 . In one or more embodiments, a gradual curving of flexible housing tube  300  may be configured to gradually curve optic fiber  310 , e.g., from an optic fiber in a third curved position  1130  to an optic fiber in a fourth curved position  1140 . Illustratively, a line tangent to optic fiber distal end  311  may be parallel to a line tangent to flexible housing tube proximal end  302 , e.g., when optic fiber  310  comprises an optic fiber in a fourth curved position  1140 . 
     In one or more embodiments, one or more properties of a steerable laser probe may be adjusted to attain one or more desired steerable laser probe features. Illustratively, a length that flexible housing tube distal end  301  extends from actuation mechanism distal end  711  may be adjusted to vary an amount of actuation of an actuation control  720  of a plurality of actuation controls  720  configured to curve flexible housing tube  300  to a particular curved position. In one or more embodiments, a stiffness of flexible housing tube  300  may be adjusted to vary an amount of actuation of an actuation control  720  of a plurality of actuation controls  720  configured to curve flexible housing tube  300  to a particular curved position. Illustratively, flexible housing tube  300  may comprise a solid tube structure. In one or more embodiments, flexible housing tube  300  may comprise one or more apertures, e.g., configured to vary a stiffness of flexible housing tube  300 . Illustratively, a material comprising flexible housing tube  300  may be adjusted to vary an amount of actuation of an actuation control  720  of a plurality of actuation controls  720  configured to curve flexible housing tube  300  to a particular curved position. In one or more embodiments, a stiffness of flexible housing tube  300  may be adjusted to vary a bend radius of flexible housing tube  300 . Illustratively, a stiffness of flexible housing tube  300  may be adjusted to vary a radius of curvature of flexible housing tube  300 , e.g., when flexible housing tube  300  is in a particular curved position. 
     In one or more embodiments, a geometry of actuation mechanism  710  may be adjusted to vary an amount of actuation of an actuation control  720  of a plurality of actuation controls  720  configured to curve flexible housing tube  300  to a particular curved position. Illustratively, a geometry of actuation mechanism guide  780  may be adjusted to vary an amount of actuation of an actuation control  720  of a plurality of actuation controls  720  configured to curve flexible housing tube  300  to a particular curved position. In one or more embodiments, a geometry of handle end cap  705  or a geometry of handle base  730  may be adjusted to vary an amount of actuation of an actuation control  720  of a plurality of actuation controls  720  configured to curve flexible housing tube  300  to a particular curved position. Illustratively, one or more locations within flexible housing tube  300  wherein cable  910  may be fixed to a portion of flexible housing tube  300  may be adjusted to vary an amount of actuation of an actuation control  720  of a plurality of actuation controls  720  configured to curve flexible housing tube  300  to a particular curved position. 
     In one or more embodiments, at least a portion of optic fiber  310  may be enclosed in an optic fiber sleeve configured to, e.g., protect optic fiber  310 , vary a stiffness of optic fiber  310 , vary an optical property of optic fiber  310 , etc. Illustratively, optic fiber  310  may comprise a buffer, a cladding disposed in the buffer, and a core disposed in the cladding. In one or more embodiments, at least a portion of optic fiber  310  may comprise a buffer configured to protect an optical property of optic fiber  310 . Illustratively, at least a portion of optic fiber  310  may comprise a buffer configured to protect an optical layer of optic fiber  310 , e.g., the buffer may protect an optical layer of a curved portion of optic fiber  310 . In one or more embodiments, at least a portion of optic fiber  310  may comprise a polyimide buffer configured to protect an optical property of optic fiber  310 . For example, at least a portion of optic fiber  310  may comprise a Kapton buffer configured to protect an optical property of optic fiber  310 . 
     Illustratively, a steerable laser probe may be configured to indicate, e.g., to a surgeon, a direction that optic fiber  310  may curve, e.g., due to an actuation of an actuation control  720  of a plurality of actuation controls  720 . In one or more embodiments, a portion of a steerable laser probe, e.g., handle  800 , may be marked in a manner configured to indicate a direction that optic fiber  310  may curve. For example, a portion of flexible housing tube  300  may comprise a mark configured to indicate a direction that optic fiber  310  may curve. Illustratively, flexible housing tube  300  may comprise a slight curve, e.g., a curve less than 7.5 degrees, when an actuation control  720  of a plurality of actuation controls  720  is fully extended relative to an actuation control guide proximal end  812 . In one or more embodiments, flexible housing tube  300  may comprise a slight curve configured to indicate a direction that optic fiber  310  may curve, e.g., due to a retraction of an actuation control  720  of a plurality of actuation controls  720  relative to an actuation control guide proximal end  812 . 
     In one or more embodiments, a steerable laser probe may comprise a pressure mechanism configured to provide a force. Illustratively, a pressure mechanism may be disposed within pressure mechanism housing  785 . For example, a pressure mechanism may be disposed within proximal chamber  740 . In one or more embodiments, a pressure mechanism may be configured to provide a constant force. Illustratively, a pressure mechanism may be configured to provide a variable force. In one or more embodiments, a pressure mechanism may be configured to provide a resistive force, e.g., to resist an extension of actuation mechanism  710  relative to handle proximal end  802 . Illustratively, a pressure mechanism may be configured to provide a facilitating force, e.g., to facilitate a retraction of actuation mechanism  710  relative to handle proximal end  802 . In one or more embodiments, a pressure mechanism may be configured to provide a resistive force, e.g., to resist a retraction of actuation mechanism  710  relative to handle proximal end  802 . Illustratively, a pressure mechanism may be configured to provide a facilitating force, e.g., to facilitate an extension of actuation mechanism  710  relative to handle proximal end  802 . In one or more embodiments, a pressure mechanism may comprise a spring or a coil. Illustratively, a pressure mechanism may comprise a pneumatic system or any system configured to provide a force. 
     In one or more embodiments, one or more actuation controls  720  may be fixed together. For example, a first actuation control  720  may be connected to a second actuation control  720  wherein an actuation of the first actuation control  720  is configured to actuate the second actuation control  720  and an actuation of the second actuation control  720  is configured to actuate the first actuation control  720 . Illustratively, each actuation control  720  of a plurality of actuation controls  720  may be connected wherein an actuation of a particular actuation control  720  is configured to actuate each actuation control  720  of the plurality of actuation controls  720 . In one or more embodiments, each actuation control  720  may be connected to another actuation control  720  of a plurality of actuation controls  720 , e.g., by a ring or any suitable structure wherein a surgeon may actuate each actuation control  720  of the plurality of actuation controls  720  in any rotational orientation of handle  800 . 
     Illustratively, cable  910  may be fixed to flexible housing tube  300  at a plurality of fixation points, e.g., to vary one or more properties of a steerable laser probe. In one or more embodiments, a length of cable  910  may be adjusted to vary an amount of retraction of an actuation control  720  of a plurality of actuation controls  720  relative to handle proximal end  802  configured to curve flexible housing tube  300  to a particular curved position. Illustratively, a steerable laser probe may comprise one or more redundant cables  910 . In one or more embodiments, one or more redundant cables  910  may be configured to maintain a particular curved position of flexible housing tube  300 , e.g., in the event that cable  910  breaks or fails. Illustratively, one or more redundant cables  910  may be configured to maintain a particular curved position of flexible housing tube  300 , e.g., in the event that a cable  910  fixation means fails. In one or more embodiments, one or more redundant cables  910  may be configured to maintain a particular curved position of flexible housing tube  300 , e.g., in the event that cable  910  is no longer configured to maintain the particular curved position of flexible housing tube  300 . Illustratively, one or more redundant cables  910  may be configured to maintain a particular curved position of flexible housing tube  300  wherein cable  910  is also configured to maintain the particular curved position of flexible housing tube  300 . 
     In one or more embodiments, flexible housing tube  300  may comprise an access window configured to allow access to a portion cable  910 . Illustratively, cable  910  may be fixed to a portion of flexible housing tube  300 , e.g., by looping a portion of cable  910  through an aperture in flexible housing tube  300 . In one or more embodiments, cable  910  may be fixed to a portion of flexible housing tube  300 , e.g., by a purely mechanical means. For example, cable  910  may be fixed to a portion of flexible housing tube  300  in a manner other than by an adhesive, a weld, etc. Illustratively, cable  910  may be fixed to a portion of flexible housing tube  300  wherein a portion of cable  910  is configured to fail at a first applied failure force and a fixation means that fixes a portion of cable  910  to a portion of flexible housing tube  300  is configured to fail at a second applied failure force. In one or more embodiments, the second applied failure force may be greater than the first applied failure force. 
       FIGS. 12A, 12B, 12C, 12D, and 12E  are schematic diagrams illustrating a gradual straightening of an optic fiber  310 .  FIG. 12A  illustrates a fully curved optic fiber  1200 . In one or more embodiments, optic fiber  310  may comprise a fully curved optic fiber  1200 , e.g., when cable  910  is fully retracted relative to flexible housing tube  300 . Illustratively, optic fiber  310  may comprise a fully curved optic fiber  1200 , e.g., when an actuation control  720  of a plurality of actuation controls  720  is fully retracted relative to an actuation control guide proximal end  812 . In one or more embodiments, optic fiber  310  may comprise a fully curved optic fiber  1200 , e.g., when actuation mechanism  710  is fully retracted relative to handle proximal end  802 . Illustratively, a line tangent to optic fiber distal end  311  may be parallel to a line tangent to flexible housing tube proximal end  302 , e.g., when optic fiber  310  comprises a fully curved optic fiber  1200 . 
       FIG. 12B  illustrates an optic fiber in a first partially straightened position  1210 . In one or more embodiments, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide distal end  811  and away from actuation control guide proximal end  812 , may be configured to gradually straighten optic fiber  310  from a fully curved optic fiber  1200  to an optic fiber in a first partially straightened position  1210 . Illustratively, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide distal end  811  and away from actuation control guide proximal end  812 , may be configured to extend actuation mechanism  710  relative to flexible housing tube  300 . In one or more embodiments, an extension of actuation mechanism  710  relative to flexible housing tube  300  may be configured to extend cable  910  relative to flexible housing tube  300 . 
     Illustratively, an extension of cable  910  relative to flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 , e.g., a portion of cable  910  fixed to a portion of flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 . In one or more embodiments, a reduction of a force, e.g., a compressive force, applied to a portion of flexible housing tube  300  may be configured to decompress a portion of flexible housing tube  300 . Illustratively, a decompression of a portion of flexible housing tube  300  may be configured to gradually straighten flexible housing tube  300 . In one or more embodiments, a gradual straightening of flexible housing tube  300  may be configured to gradually straighten optic fiber  310 , e.g., from a fully curved optic fiber  1200  to an optic fiber in a first partially straightened position  1210 . In one or more embodiments, a line tangent to optic fiber distal end  311  may intersect a line tangent to flexible housing tube proximal end  302  at a first partially straightened angle, e.g., when optic fiber  310  comprises an optic fiber in a first partially straightened position  1210 . Illustratively, the first partially straightened angle may comprise any angle less than 180 degrees. For example, the first partially straightened angle may comprise a 135 degree angle. 
       FIG. 12C  illustrates an optic fiber in a second partially straightened position  1220 . In one or more embodiments, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide distal end  811  and away from actuation control guide proximal end  812 , may be configured to gradually straighten optic fiber  310  from an optic fiber in a first partially straightened position  1210  to an optic fiber in a second partially straightened position  1220 . Illustratively, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide distal end  811  and away from actuation control guide proximal end  812 , may be configured to extend actuation mechanism  710  relative to flexible housing tube  300 . In one or more embodiments, an extension of actuation mechanism  710  relative to flexible housing tube  300  may be configured to extend cable  910  relative to flexible housing tube  300 . Illustratively, an extension of cable  910  relative to flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 , e.g., a portion of cable  910  fixed to a portion of flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 . In one or more embodiments, a reduction of a force, e.g., a compressive force, applied to a portion of flexible housing tube  300  may be configured to decompress a portion of flexible housing tube  300 . Illustratively, a decompression of a portion of flexible housing tube  300  may be configured to gradually straighten flexible housing tube  300 . In one or more embodiments, a gradual straightening of flexible housing tube  300  may be configured to gradually straighten optic fiber  310 , e.g., from an optic fiber in a first partially straightened position  1210  to an optic fiber in a second partially straightened position  1220 . In one or more embodiments, a line tangent to optic fiber distal end  311  may intersect a line tangent to flexible housing tube proximal end  302  at a second partially straightened angle, e.g., when optic fiber  310  comprises an optic fiber in a second partially straightened position  1220 . Illustratively, the second partially straightened angle may comprise any angle less than the first partially straightened angle. For example, the second partially straightened angle may comprise a 90 degree angle. 
       FIG. 12D  illustrates an optic fiber in a third partially straightened position  1230 . In one or more embodiments, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide distal end  811  and away from actuation control guide proximal end  812 , may be configured to gradually straighten optic fiber  310  from an optic fiber in a second partially straightened position  1220  to an optic fiber in a third partially straightened position  1230 . Illustratively, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide distal end  811  and away from actuation control guide proximal end  812 , may be configured to extend actuation mechanism  710  relative to flexible housing tube  300 . In one or more embodiments, an extension of actuation mechanism  710  relative to flexible housing tube  300  may be configured to extend cable  910  relative to flexible housing tube  300 . Illustratively, an extension of cable  910  relative to flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 , e.g., a portion of cable  910  fixed to a portion of flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 . In one or more embodiments, a reduction of a force, e.g., a compressive force, applied to a portion of flexible housing tube  300  may be configured to decompress a portion of flexible housing tube  300 . Illustratively, a decompression of a portion of flexible housing tube  300  may be configured to gradually straighten flexible housing tube  300 . In one or more embodiments, a gradual straightening of flexible housing tube  300  may be configured to gradually straighten optic fiber  310 , e.g., from an optic fiber in a second partially straightened position  1220  to an optic fiber in a third partially straightened position  1230 . In one or more embodiments, a line tangent to optic fiber distal end  311  may intersect a line tangent to flexible housing tube proximal end  302  at a third partially straightened angle, e.g., when optic fiber  310  comprises an optic fiber in a third partially straightened position  1230 . Illustratively, the third partially straightened angle may comprise any angle less than the second partially straightened angle. For example, the third partially straightened angle may comprise a 45 degree angle. 
       FIG. 12E  illustrates an optic fiber in a fully straightened position  1240 . In one or more embodiments, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide distal end  811  and away from actuation control guide proximal end  812 , may be configured to gradually straighten optic fiber  310  from an optic fiber in a third partially straightened position  1230  to an optic fiber in a fully straightened position  1240 . Illustratively, an actuation of an actuation control  720  within an actuation control guide  810 , e.g., towards actuation control guide distal end  811  and away from actuation control guide proximal end  812 , may be configured to extend actuation mechanism  710  relative to flexible housing tube  300 . In one or more embodiments, an extension of actuation mechanism  710  relative to flexible housing tube  300  may be configured to extend cable  910  relative to flexible housing tube  300 . Illustratively, an extension of cable  910  relative to flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 , e.g., a portion of cable  910  fixed to a portion of flexible housing tube  300  may be configured to reduce a force applied to a portion of flexible housing tube  300 . In one or more embodiments, a reduction of a force, e.g., a compressive force, applied to a portion of flexible housing tube  300  may be configured to decompress a portion of flexible housing tube  300 . Illustratively, a decompression of a portion of flexible housing tube  300  may be configured to gradually straighten flexible housing tube  300 . In one or more embodiments, a gradual straightening of flexible housing tube  300  may be configured to gradually straighten optic fiber  310 , e.g., from an optic fiber in a third partially straightened position  1230  to an optic fiber in a fully straightened position  1240 . In one or more embodiments, a line tangent to optic fiber distal end  311  may be parallel to a line tangent to flexible housing tube proximal end  302 , e.g., when optic fiber  310  comprises an optic fiber in a fully straightened position  1240 . 
     Illustratively, a surgeon may aim optic fiber distal end  311  at any of a plurality of targets within an eye, e.g., to perform a photocoagulation procedure, to illuminate a surgical target site, etc. In one or more embodiments, a surgeon may aim optic fiber distal end  311  at any target within a particular transverse plane of the inner eye by, e.g., rotating handle  800  to orient flexible housing tube  300  in an orientation configured to cause a curvature of flexible housing tube  300  within the particular transverse plane of the inner eye and varying an amount of actuation of an actuation control  720  of a plurality of actuation controls  720 . Illustratively, a surgeon may aim optic fiber distal end  311  at any target within a particular sagittal plane of the inner eye by, e.g., rotating handle  800  to orient flexible housing tube  300  in an orientation configured to cause a curvature of flexible housing tube  300  within the particular sagittal plane of the inner eye and varying an amount of actuation of an actuation control  720  of a plurality of actuation controls  720 . In one or more embodiments, a surgeon may aim optic fiber distal end  311  at any target within a particular frontal plane of the inner eye by, e.g., varying an amount of actuation of an actuation control  720  of a plurality of actuation controls  720  to orient a line tangent to optic fiber distal end  311  wherein the line tangent to optic fiber distal end  311  is within the particular frontal plane of the inner eye and rotating handle  800 . Illustratively, a surgeon may aim optic fiber distal end  311  at any target located outside of the particular transverse plane, the particular sagittal plane, and the particular frontal plane of the inner eye, e.g., by varying a rotational orientation of handle  800  and varying an amount of actuation of an actuation control  720  of a plurality of actuation controls  720 . In one or more embodiments, a surgeon may aim optic fiber distal end  311  at any target of a plurality of targets within an eye, e.g., without increasing a length of a portion of a steerable laser probe within the eye. Illustratively, a surgeon may aim optic fiber distal end  311  at any target of a plurality of targets within an eye, e.g., without decreasing a length of a portion of a steerable laser probe within the eye. 
     It is to be understood that the above description is intended to be illustrative, and not restrictive. For example, the above-described embodiments (and/or aspects thereof) may be used in combination with each other. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the subject matter set forth herein without departing from its scope. While the dimensions and types of materials described herein are intended to define the parameters of the disclosed subject matter, they are by no means limiting and are exemplary embodiments. Many other embodiments will be apparent to those of skill in the art upon reviewing the above description. The scope of the subject matter described herein should, therefore, be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled. In the appended claims, the terms “including” and “in which” are used as the plain English equivalents of the respective terms “comprising” and “wherein.” Moreover, in the following claims, the terms “first,” “second,” and “third,” etc. are used merely as labels, and are not intended to impose numerical requirements on their objects. Further, the limitations of the following claims are not written in means-plus-function format and are not intended to be interpreted based on 35 U.S.C. § 112(f), unless and until such claim limitations expressly use the phrase “means for” followed by a statement of function void of further structure. 
     As used herein, an element or step recited in the singular and proceeded with the word “a” or “an” should be understood as not excluding plural of said elements or steps, unless such exclusion is explicitly stated. Furthermore, references to “one embodiment” of the presently described subject matter are not intended to be interpreted as excluding the existence of additional embodiments that also incorporate the recited features. Moreover, unless explicitly stated to the contrary, embodiments “comprising” or “having” an element or a plurality of elements having a particular property may include additional such elements not having that property. 
     This written description uses examples to disclose several embodiments of the subject matter set forth herein, including the best mode, and also to enable a person of ordinary skill in the art to practice the embodiments of disclosed subject matter, including making and using the devices or systems and performing the methods. The patentable scope of the subject matter described herein is defined by the claims, and may include other examples that occur to those of ordinary skill in the art. Such other examples are intended to be within the scope of the claims if they have structural elements that do not differ from the literal language of the claims, or if they include equivalent structural elements with insubstantial differences from the literal languages of the claims. 
     The foregoing description of certain embodiments of the present inventive subject matter will be better understood when read in conjunction with the appended drawings. To the extent that the figures illustrate diagrams of the functional blocks of various embodiments, the functional blocks are not necessarily indicative of the division between hardware circuitry. Thus, for example, one or more of the functional blocks (for example, communication unit, control system, etc.) may be implemented in a single piece of hardware (for example, a general-purpose signal processor, microcontroller, random access memory, hard disk, and the like). Similarly, the programs may be stand-alone programs, may be incorporated as subroutines in an operating system, may be functions in an installed software package, and the like. The various embodiments are not limited to the arrangements and instrumentality shown in the drawings. 
     Since certain changes may be made in the above-described systems and methods, without departing from the spirit and scope of the inventive subject matter herein involved, it is intended that all of the subject matter of the above description or shown in the accompanying drawings shall be interpreted merely as examples illustrating the inventive concept herein and shall not be construed as limiting the inventive subject matter. 
     Changes can be made in the above constructions without departing from the scope of the disclosure, it is intended that all matter contained in the above description or shown in the accompanying drawings shall be interpreted as illustrative and not in a limiting sense.