Patent Publication Number: US-2012034214-A1

Title: Methods and kits for determining the prognosis of pulmonary sarcoidosis

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application claims priority benefit of U.S. Provisional Patent Application 61/366,872, filed Jul. 22, 2010, which is hereby incorporated herein by reference in its entirety. 
    
    
     FIELD OF THE INVENTION 
     The invention relates to determining the prognosis of pulmonary sarcoidosis. 
     BACKGROUND OF THE INVENTION 
     Sarcoidosis is a multisystem granulomatous inflammatory disease of unknown aetiology, characterized by non-caseating granulomatous deposits and intense T cell activity. Almost any organs can be affected but the lungs are by far the most common. Approximately 95% of patients have computed tomographic evidence of deposits in the lungs. Sarcoidosis affecting the lungs is known as pulmonary sarcoidosis. 
     Significant advances have been made to characterize the immunological features of sarcoidosis, but the central immunological mechanisms remain unclear. There is evidence pointing to overactivity of TH1-biased CD4 T cells as the initial abnormality leading to activation of macrophages and downstream formation of granuloma. It is also possible that the macrophage is the primary cellular abnormality, and an inability to degrade an intracellular antigen causes the formation and persistence of granuloma. Overall, there is general agreement that the condition is caused by a complex genetic susceptibility to granulomagenesis, triggered by an unknown inhaled antigen. Genome wide association studies and directed SNP searches have identified ANXA11 (annexin A11) and BTNL-2 as susceptibility genes, both of which are related to control of T cell activity. 
     The symptoms of sarcoidosis usually appear gradually but can occasionally appear suddenly. The clinical course varies dramatically. Most patients with pulmonary sarcoidosis have a good prognosis. The immune disturbances and granulomatous deposits resolve spontaneously over 2 to 5 years. This is known as self-limiting sarcoidosis. However about 30% of patients have progressive disease leading to varying degrees of pulmonary fibrosis and even death in 1 to 5% of cases. This is know as progressive sarcoidosis. Currently almost nothing is known of the cause of this progression in disease and with the exception of patients who present with Loefgren&#39;s syndrome, there are no markers to differentiate between these two groups of patients. Indeed, both groups of patients often present with very similar (or no) symptoms. 
     There is a long-standing need for a reliable means of separating patients with self-limiting from those with progressive pulmonary sarcoidosis. That is, there is a need for a means for determining which patients will have progressive pulmonary sarcoidosis. 
     SUMMARY OF THE INVENTION 
     The invention provides a method for determining the prognosis of pulmonary sarcoidosis in an individual subject, comprising conducting gene expression analysis on a sample from the subject, wherein said subject has or is suspected of having pulmonary sarcoidosis; and said sample is obtained by bronchoscopy under procedural methods not requiring general anesthesia, preferably a transbronchial lung biopsy (TBB). Gene expression analysis typically comprises determining the expression level of one or more genes. 
     In one embodiment, the method of the invention comprises categorising the sarcoidosis as either progressive or self-limiting. Typically, this embodiment is carried out by a method comprising:
     (a) measuring the expression level of at least one gene set in the sample taken from the subject;   (b) comparing the measured expression level to the expression level for the same at least one gene set as previously determined in:
       patients confirmed as having progressive sarcoidosis, and/or   patients confirmed as having self-limiting sarcoidosis and   
       (c) thereby categorising the sarcoidosis in said subject as either progressive or self-limiting.   

     In one embodiment, the invention provides a method for determining the prognosis of pulmonary sarcoidosis in an individual subject, comprising conducting gene expression analysis on a sample from the subject, 
     wherein said subject has or is suspected of having pulmonary sarcoidosis and wherein said gene expression analysis comprises determining the expression level of:
         the gene set consisting of the genes listed in Table 1 or Table 3; or   at least one gene set from those listed in Table 2 or Table 5; or   at least one gene set selected from the “immune response”, “immune system process”, “lymphocyte activation”, “defence response”, and “leukocyte activation” gene sets, or any combination of said gene sets; or   at least one gene set from each of the major categories shown in Table 5.       

     In one embodiment, the invention provides a method of slowing or preventing the development of pulmonary fibrosis in an individual subject, comprising; 
     (i) assessing the prognosis of pulmonary sarcoidosis in the subject using a method according to the invention; and
 
(ii) administering to a subject having sarcoidosis categorised in (i) as progressive, a therapeutically effective amount of an agent suitable for the treatment of pulmonary fibrosis.
 
     In one embodiment, the invention provides a test kit for use in a method for determining the prognosis of pulmonary sarcoidosis in an individual subject, which test kit comprises one or more agents suitable for analysing gene expression in a sample taken from the subject. 
    
    
     
       DESCRIPTION OF THE FIGURES 
         FIG. 1 . Gene expression profile for progressive, fibrotic (P-F) and self-limiting (N-SL) patients. Panel A. Expression profile for the two groups of patients showing 334 differentially expressed genes (p&lt;0.01, Bayesian moderated t-test). Red areas indicate increased gene expression relative to mean of all samples, and green decreased expression. Each column represents one patient, and each row a gene. In general, all genes above the horizontal line are relatively over-expressed in N-SL patients and relatively under-expressed in P-F patients. Genes below the horizontal line are relatively over-expressed in P-F patients and relatively under-expressed in N-SL patients. Hierarchical clustering was used to show the degree of similarity of overall gene expression profile between each patient (top dendogram) and the left dendogram shows the degree of similarity between the genes. Panel B. Top 50 genes with increased expression in P-F compared to N-SL group, ranked by fold change (top panel), and all 51 down regulated genes in P-F compared to N-SL by fold change (Panel C); p values from Bayesian moderated t test. The full list of differentially expressed genes is given in Table 3. 
         FIG. 2 . GSEA analysis of microarray gene signals between N-SL and P-F groups, using Gene Ontology (GO) defined gene-sets. Panel A shows the top 5 GO-defined gene-sets that were significantly enriched among genes up-regulated in the P-F group (FDR q&lt;0.001). The red-blue strip represents the 26,626 genes expressed in the samples ranked according to differential expression between the N-SL and P-F groups (hence phenotype). Increasing gene signal in the N-SL is towards the left end of the bar, increasing gene signal in the P-F group is towards the right. Each line in the ‘bar code’ represents presence of a gene from the GO-defined gene-set (eg immune system process gene set) within the ranked genes. The enrichment score (y axis) is a running-sum statistic which increases when the gene in that particular gene-set is found in the ranked gene list and decreases otherwise. The changes are weighted such that the magnitude is greater if there is a strong correlation of the gene from the defined gene-set with phenotype (i.e. found towards the extreme ends of the ranked list) The leading edge subset is defined as genes appearing at or before the running sum reaches maximum deviation from zero. Panel B. Mean intensity of expression of leading edge genes from gene-sets with FDR q&lt;0.01 for each patient. Each row represents a gene-set and shows the mean expression of leading genes from that gene-set, and each column is a patient, clustered by hierachical method to reflect degree of similarity. The gene-sets are grouped according to biological categories, and the panel shows the 10 main categories for these gene-sets (composition of these categories can be found in Table 5). The bar at the top indicates the relative expression in the N-SL versus P-F groups, with negative scores (relative under-expression) being shown for the N-SL group to the left, and positive scores (relative over-expression) being shown for the P-F group to the right. 
         FIG. 3 . Quality of lung biopsy samples using a routine clinical tool (bronchoscopic transbronchial biopsy). Panel A shows RNA quality (18S and 28S profiles), showing minimal degradation of RNA from tissue sample, and comparative quality for all fifteen patients. Panel B. Comparison of mean gene expression signal for all genes in both groups. Panel C. Boxplot for RMA normalised intensity for all the genes for each patient. “1_Good” refers to a N-SL patient in Set 1; “2_Poor” refers a P-F patient from Set 2. Panel D. Fold change of 5 random genes, comparing mean expression for each gene in N-SL to P-F group, using qPCR and DNA microarray to determine gene expression. 
     
    
    
     DESCRIPTION OF THE TABLES 
     Table 1. A list of the top 50 individual genes found to have increased expression in progressive-fibrotic sarcoidosis (PF) patients compared to nodular, self-limiting sarcoidosis (N-SL) patients, ranked by fold change (FC) (top panel); and all 52 down-regulated genes in PF compared to N-SL patients, ranked by fold change (bottom panel). p values are from a Bayesian moderated t test. 
     Table 2. A list of the 43 gene sets that were most significantly enriched in terms of up-regulated expression of their component genes in P-F patients compared to N-SL patients (FDR q value q&lt;0.0001). 
     Table 3. Full list of genes found differentially expressed between the two groups of patients with p&lt;0.01 (Bayesian moderated t-test). FC refers to fold change as of the average normalised-intensity for that gene in N-SL group compared to P-F group. 
     Table 4. Full list of gene ontology-defined biological categories found in P-F patients with their normalised enrichment score (NES) and FDR q values. 
     Table 5. A list of the gene sets that were most significantly enriched in terms of up-regulated expression of their component genes in P-F patients compared to N-SL patients (FDR q value q&lt;0.01), grouped in major categories on the basis of overlapping leading edge genes, and being directly related terms in the gene ontology hierarchy. 
     Table 6. Complete list of the genes in the gene sets of Tables 2, 4 and 5. 
     DETAILED DESCRIPTION OF THE INVENTION 
     Subjects 
     The present invention relates to a method for determining the prognosis of pulmonary sarcoidosis in an individual subject. More specifically, the invention relates to determining whether the individual has progressive or self-limiting pulmonary sarcoidosis. The individual under test typically has or is suspected of having pulmonary sarcoidosis. The individual is typically a mammal. The mammal is typically a human or a domestic mammal such as a horse, a cow, a sheep, a dog or a cat. The individual is preferably a human. 
     The individual may have been diagnosed as having pulmonary sarcoidosis, or be suspected of having pulmonary sarcoidosis, because they display one or more symptoms commonly associated with sarcoidosis. However, the subject may display no such symptoms. The common symptoms of sarcoidosis are vague, and can sometimes be similar to symptoms of lymphoma and tuberculosis. Typically, a sarcoidosis patient will present with clinical features in accordance to those set out in the Statement on Sarcoidosis published by the American Thoracic Society (Am J Respir Crit Care Med. 1999; 160(2):736-55). 
     Typically, a sarcoidosis patient will present with one or more of the following symptoms:
         Symptoms associated with the lung: selected from shortness of breath, wheezing, hoarseness, dry or productive cough, chest pain, and tightness in the chest;   Symptoms associated with the eye: selected from uveitis, uveoparotitis, iridocyclitis, retinal inflammation, loss of visual acuity or blindness, eye dryness, redness, tearing, burning or itching, and photophobia;   Cutaneous symptoms: selected from range from rashes, nodules, erythema nodosum and lupus pernio;   General symptoms: selected from joint and muscle pain, irregular heartbeat, loss of sensation, loss of muscle strength, headache, dizziness, weight loss, fever and fatigue.       

     Patients with suspected sarcoidosis are typically assessed with a chest radiograph for pulmonary involvement. The radiograph may be generated by, for example, X-ray, CT, MRI or PET scan, typically CT scan. Radiographs are typically assigned a stage of 0-4 according to the presence or absence of hilar adenopathy and parenchymal disease, e.g., pulmonary infiltration or fibrosis. Thus there are five stages:
         Stage 0: no visible intrathoracic findings;   Stage 1: bilateral hilar lymphadenopathy (BHL), which may be accompanied by paratracheal adenopathy. Lung fields are clear of infiltrates.   Stage 2: bilateral hilar adenopathy (BHL) accompanied by parenchymal infiltration;   Stage 3: parenchymal infiltration without bilateral hilar adenopathy (BHL)   Stage 4: advanced pulmonary fibrosis with evidence of honey-combing, hilar retraction, bullae, cysts, and emphysema.       

     Subjects tested using the present invention will typically produce radiographs which are assigned to stages 1 to 4. 
     Typically, an individual subject may be suspected of having pulmonary sarcoidosis because of the presence of one or more symptoms associated with the lung (typically cough or breathlessness) and/or abnormalities on a chest radiograph. 
     Prognosis 
     The present invention involves conducting gene expression analysis on a sample from a subject, wherein said subject has or is suspected of having pulmonary sarcoidosis and said sample is typically a lung biopsy obtained by bronchoscopy under procedural methods not requiring general anesthesia. Gene expression analysis typically comprises determining the expression level of one or more genes. 
     Gene expression refers to the production of a biological product encoded by a nucleic acid sequence, such as a gene sequence. This biological product, referred to herein as a “gene product”, may be a nucleic acid or a polypeptide. The nucleic acid is typically an RNA molecule which is produced as a transcript from the gene sequence. The RNA molecule can be any type of RNA molecule, whether either before (e.g., precursor RNA) or after (e.g., mRNA) post-transcriptional processing. cDNA prepared from the mRNA of a sample is also considered a gene product. The polypeptide gene product is a peptide or protein that is encoded by the coding region of the gene, and is produced during the process of translation of the mRNA. The term “gene expression level” refers to a measure of a gene product(s) of the gene and typically refers to the relative or absolute amount or activity of the gene product. Gene expression analysis comprises determining the expression level of one or more genes. 
     The expression level of a gene in a sample may be determined using any appropriate method. Gene expression levels are typically determined by measuring the amount or activity of a desired gene product (i.e., an RNA or a polypeptide encoded by the coding sequence of the gene) in a biological sample. Any biological sample can be analyzed. A sample is typically a bodily tissue or fluid, such as blood, serum, plasma, urine, bone marrow, lymphatic fluid, and CNS or spinal fluid. For the purposes of the present invention the sample is typically biopsy of lung tissue obtained by bronchoscopy under procedural methods not requiring general anesthesia. A preferred procedural method is transbronchial lung biopsy (TBB). Other methods include lung mucosal biopsy, provided general anesthesia is not required. 
     TBB is typically performed by a pulmonologist and requires local anaesthetic to be applied to the mouth and throat. By contrast to open lung biopsy, general anesthetic is not required, the technique is considerably less invasive, and smaller tissue samples are taken. To carry out the TBB, a bronchoscope is inserted through the nose or mouth until it passes through the throat into the windpipe (trachea) and air passages of the lungs (bronchi). Samples of lung fluids may be taken through the bronchoscope. Salt water (saline) may be used to flush the area and collect cells for examination. A sample of lung tissue for the biopsy is removed using an appropriate tool, such as forceps, which is passed through the bronchoscope. Multiple samples may be collected. In some cases fluoroscopy, e.g. a chest X-ray, may be used during the procedure to help direct the forceps to the correct area of the lung. For lung mucosal biopsy, the same procedure and methods are employed as for TBB except that the forcep is targeted to the mucosa (lining of airways) visible at bronchoscopy. 
     Gene expression levels can be assayed qualitatively or quantitatively. The level of a gene product is measured or estimated in a sample either directly (e.g., by determining or estimating absolute level of the gene product) or relatively (e.g., by comparing the observed expression level to a gene expression level of another samples or set of samples). Measurements of gene expression levels may, but need not, include a normalization process. 
     Typically, mRNA levels (or cDNA prepared from such mRNA) are assayed to determine gene expression levels. Methods to detect gene expression levels include Northern blot analysis, SI nuclease mapping, quantitative polymerase chain reaction (qPCR), reverse transcription in combination with quantitative polymerase chain reaction (RT-qPCR), and reverse transcription in combination with the ligase chain reaction (RT-LCR). Multiplexed methods that allow the measurement of expression levels for more than one gene simultaneously are preferred. Measurement of gene expression levels using an oligonucleotide microarray, such as a DNA microarray, is particularly preferred. Alternative multiplexed methods include serial analysis of gene expression (SAGE) and next generation parallel and target-enrichment DNA sequencing techniques. 
     DNA microarrays typically consist of an arrayed series of thousands of microscopic spots of DNA oligonucleotides, called features, each containing picomoles (10 −12  moles) of a specific DNA sequence, known as probes. The probes are usually a short section of a gene or other DNA element that are used to hybridize a cDNA or cRNA sample (called target) under high-stringency conditions by base-pairing between complementary nucleotides. Probe-target hybridization is usually detected and quantified by detection of chemiluminescence-fluorophore-, or silver-labeled targets to determine relative abundance of nucleic acid sequences in the target. Since an array can contain tens of thousands of probes, a microarray experiment can accomplish many genetic tests in parallel. In standard microarrays, the probes are attached to a solid surface by a covalent bond to a chemical matrix (via epoxy-silane, amino-silane, lysine, polyacrylamide or others). The solid surface is typically a glass or a silicon chip. Other microarray platforms use microscopic beads, instead of the large solid support. DNA arrays are different from other types of microarray only in that they either measure DNA or use DNA as part of the detection system. Whole human genome arrays are particularly preferred, such as the Affymetrix Gene ST 1.0 array. Such arrays provide probes for whole transcript coverage, and therefore a more complete picture of gene expression, for approximately 29,000 genes from the human genome. 
     Alternatively or in addition, polypeptide levels can be assayed. Immunological techniques that involve antibody binding, such as enzyme linked immunosorbent assay (ELISA) and radioimmunoassay (RIA), are typically employed. Where activity assays are available, the activity of a polypeptide of interest can be assayed directly. 
     In the method of the invention, the observed expression level in the lung tissue biopsy for at least one group (or set) of genes is measured to determine the prognosis of pulmonary sarcoidosis in the individual subject. The at least one group of genes that is measured has been determined by evaluation typically involving a comparison between the observed gene expression level for said gene set in patients who have progressive disease (P-F) and the expression level for the same gene set in patients with self-limiting disease (N-SL). A gene set is selected for measurement in the method of the invention if said gene set is significantly differentially expressed between P-F and N-SL patients. Differential expression is determined as significant by use of statistical analyses designed for comparison of large numbers of variable. One typical method is the Bayesian moderated t-test, which is applied to identify differentially expressed genes between P-F and N-SL using the ‘limma’ (linear models for microarray analysis) package from BioConductor. 
     Typically, a gene set will be selected for measurement in the method of the invention where it is found that said group displays statistically significantly different expression (FDR at q=0.01 or below, more preferably q=0.001 or below) in patients with progressive disease relative to those with self-limiting disease. The gene set may typically correspond to a gene ontology-defined set of genes, such as the gene sets shown in Tables 2 and 5. When identifying a gene set of interest, particular genes within each set may be further categorised as “leading edge” genes. These are the genes which contribute most highly to the differential expression of the gene set between patients with progressive disease relative to those with self-limiting disease. The “leading edge” genes are those genes most likely to participate directly in the biological process defined by a particular gene ontology-defined set of genes. 
     Typically, the method of the invention may involve measurement of the expression level of at least one gene set from those listed in Table 2 or Table 5. The gene set may consist of the genes listed in Table 1 or Table 3. The method of the invention may involve measurement of the expression level of the “immune response” and/or “immune system process” and/or “lymphocyte activation” and/or “defence response” and/or “leukocyte activation” gene sets, or any combination of said gene sets. 
     The method may involve measurement of the expression level of at least two, three, four, five, six, seven, eight, nine, ten, twenty, thirty or all of the gene sets in Table 2. 
     The method may involve measurement of the expression level of at least one gene set from Table 5, more preferably at least two, three, four, five, six, seven, eight, nine, ten, twenty, thirty, forty, fifty, sixty, seventy, eighty, ninety, a hundred, or all of the gene sets in Table 5. 
     The gene sets in Table 5 are grouped into 10 major categories. Typically, the method of the invention may involve measurement of the expression level at least one gene set from at least one, two, three, four, five, six, seven, eight, nine, or all of the major categories shown in Table 5. 
     Measurement of the expression level of a gene set may typically require measurement of the expression level of each gene in that gene set. Alternatively, it may require measurement of only a representative sample of genes within a gene set. That is, the expression level of at least one, two, three, four, five, ten, twenty, thirty, forty, fifty, sixty, seventy, eighty, ninety, a hundred, or all of the genes in gene set may be measured in order to evaluate the expression level of the gene set. Alternatively, the expression level of at least 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100% of the genes in a gene set may be measured in order to evaluate the expression level of the gene set. In one embodiment, only the expression level of the “leading edge” genes in a gene set will be measured in order to determine the expression level of that gene set. In one embodiment, 50%, 60%, 70%, 80%, 90% or 100% of the genes listed in Table 1 will be measured in order to determine the expression level of the gene set consisting of the genes listed in Table 1 or Table 3. 
     A method of the invention typically comprises categorising the sarcoidosis as either progressive or self-limiting. Typically, this method comprises:
     (a) measuring the expression level at least one gene set in the sample taken from the subject;   (b) comparing the measured expression level to the expression level for the same at least one gene set as previously determined in:
       patients confirmed as having progressive sarcoidosis, and/or   patients confirmed as having self-limiting sarcoidosis and   
       (c) thereby categorising the sarcoidosis in said subject as either progressive or self-limiting.   

     Step (c) may typically comprise categorising the sarcoidosis as:
         progressive; if the expression level of the at least one gene set in the sample from the subject is significantly different to the corresponding expression level in patients confirmed as having self-limiting sarcoidosis, or if the expression level of the at least one gene set is not significantly different to the corresponding expression level in patients confirmed as having progressive sarcoidosis; or   self-limiting; if the expression level of the at least one gene set in the sample from the subject is significantly different to the corresponding expression level in patients confirmed as having progressive sarcoidosis, or if the expression level of the at least one gene set is not significantly different to the corresponding expression level in patients confirmed as having self-limiting sarcoidosis.       

     Where more than one gene set is measured, the above categorisations in step (c) will typically require a majority of the measured gene sets to have the significantly different or not significantly different expression levels (as appropriate) in order to categorise the sarcoidosis in a subject as either progressive or self-limiting. 
     Kits 
     The invention further provides a test kit for use in a method for determining the prognosis of pulmonary sarcoidosis in an individual subject, which test kit comprises one or more agents suitable for analysing gene expression in a sample taken from the subject. The kit preferably comprises at least one microarray comprising a probe for each of the genes in at least one group of genes from the biologically-related categories specified above. The kit may additionally comprise one or more other reagents or instruments which enable any of the embodiments of the method mentioned above to be carried out. The kit may, optionally, comprise instructions to enable the kit to be used in the method of the invention or details regarding which individuals the method may be carried out upon. 
     Therapy 
     The present invention also relates to the treatment of an individual identified by a method of the invention as having progressive pulmonary sarcoidosis. Thus, a substance for use in treating pulmonary sarcoidosis may be used in a method of slowing or preventing the development of pulmonary fibrosis in an individual identified by a method of the invention as having progressive pulmonary sarcoidosis. The condition of an individual identified by a method of the invention as having progressive pulmonary sarcoidosis can therefore be improved by administration of such a substance. Patient outcome can thereby be improved. A therapeutically effective amount of a substance suitable for the treatment of pulmonary fibrosis may be given to an individual identified by a method of the invention as in need thereof. Substances suitable for the treatment of pulmonary fibrosis typically include corticosteroids, new generation ‘biologics’ or immunosuppressive agents. Specific examples of corticosteroids include Prednisolone, Hydrocsortisone, and Dexamethasone. Specific examples of new generation ‘biologics’ include Rituximab and anti-TNFalpha receptor therapies such as Adalimumab, Certolizumab pegol, Golimumab and Etanercept. Specific examples of immunosuppressive agents include Methotrexate, Azathhioprine, and Mycophenolic acid. 
     A substance suitable for the treatment of pulmonary fibrosis is typically formulated for administration in the present invention with a pharmaceutically acceptable carrier or diluent. The pharmaceutical carrier or diluent may be, for example, an isotonic solution. For example, solid oral forms may contain, together with the active substance, diluents, e.g. lactose, dextrose, saccharose, cellulose, corn starch or potato starch; lubricants, e.g. silica, talc, stearic acid, magnesium or calcium stearate, and/or polyethylene glycols; binding agents; e.g. starches, gum arabic, gelatin, methylcellulose, carboxymethylcellulose or polyvinyl pyrrolidone; disaggregating agents, e.g. starch, alginic acid, alginates or sodium starch glycolate; effervescing mixtures; dyestuffs; sweeteners; wetting agents, such as lecithin, polysorbates, laurylsulphates; and, in general, non-toxic and pharmacologically inactive substances used in pharmaceutical formulations. Such pharmaceutical preparations may be manufactured in known manner, for example, by means of mixing, granulating, tabletting, sugar-coating, or film-coating processes. 
     Liquid dispersions for oral administration may be syrups, emulsions or suspensions. The syrups may contain as carriers, for example, saccharose or saccharose with glycerine and/or mannitol and/or sorbitol. 
     Suspensions and emulsions may contain as carrier, for example a natural gum, agar, sodium alginate, pectin, methylcellulose, carboxymethylcellulose, or polyvinyl alcohol. The suspensions or solutions for intramuscular injections may contain, together with the active substance, a pharmaceutically acceptable carrier, e.g. sterile water, olive oil, ethyl oleate, glycols, e.g. propylene glycol, and if desired, a suitable amount of lidocaine hydrochloride. 
     Solutions for intravenous administration or infusion may contain as carrier, for example, sterile water or preferably they may be in the form of sterile, aqueous, isotonic saline solutions. 
     A therapeutically effective amount of a substance suitable for the treatment of pulmonary fibrosis is administered to a patient identified according to a method of the invention. The dose, for example of a corticosteroid, may be determined according to various parameters, especially according to the substance used; the age, weight and condition of the patient to be treated; the route of administration; and the required regimen. Again, a physician will be able to determine the required route of administration and dosage for any particular patient. 
     All references listed herein are incorporated herein by reference in their entireties. 
     The following Example illustrates the invention: 
     Example 1 
     Methods 
     Study Population 
     Fifteen patients with histology-proven pulmonary sarcoidosis were recruited for the study. All patients were Caucasians, had never-smoked, were not on any inhaled or oral medications at the point of sampling, and did not present with Loefgren syndrome. Patients had only one other organ of involvement (eye or skin). All patients had active disease at the point of sampling as characterised by presence of nodularity on high-resolution thoracic CT (HRCT) scan and at least one of the following—respiratory or constitutive symptoms, peripheral lymphopenia or raised serum angiotensin-converting enzyme (ACE). In some patients, mild fibrosis was evident on thoracic HRCT. Transbronchial biopsy was performed at the point of presentation and patients were then followed up for two years. Biopsy was targeted to areas of disease (nodularity or fibro-nodularity) using CT-images. Half the sample from each patient was sent for histological analysis for granuloma and the other half (two to three biopsies) immediately transferred to RNA-later™. Patients were classified into ‘nodular, self-limiting’ (N-SL) or ‘progressive, fibrotic’ (P-F) pulmonary disease groups on the basis of persistence of symptoms and changes on CXR over two years. In the former, patients had minor symptoms (occasional cough), normal formal pulmonary function tests (FEV1, FVC and TLCO or KCO) but nodularity in typical distribution in the lung interstitium on high-resolution thoracic CT scanning; and no change in chest X ray or symptoms in the ensuing two years. In the P-F group, patients presented with fibro-nodular changes on CT scans, an abnormal spirometry or KCO, and showed persistent or progressive respiratory symptoms over two years. 
     The first eight patients fitting the description above were entered into the study and processed as a set (Set 1). The next eight patients fitting the same characteristics (Set 2) were processed as a second set. All patients were followed up for two years before final confirmation of groupings into N-SL or P-F. 
     All patients gave informed consent and the study was approved by the Oxfordshire Research Ethics Committee. 
     Gene-Expression Profiling 
     Gene expression profiling was performed using the Affymetrix Gene ST 1.0 array which provides probes for whole transcript coverage, and therefore a more complete picture of gene expression, for approximately 29,000 genes from the human genome. Total RNA from the lung biopsies was extracted within 24 hours using the Qiagen RNeasy Mini kit according to manufacturer&#39;s instructions. RNA quality was assessed using a high-resolution electrophoresis bioanalyser system (Agilent Technologies). Isolated total RNA was then taken through standard protocols. 
     Raw data were processed using software (Affymetrix Power Tools) to generate RMA-normalised gene level intensities. Further analysis was performed using the R statistical program and BioConductor packages. Quality control procedures included a comparison of boxplots of RMA normalized expression values between samples, and hierarchical clustering of all samples to identify any potential outliers. Based on these and the assessment of RNA quality, 15 of the 16 samples were deemed suitable for further analysis. Raw microarray data has been deposited with GEO (Accession number GSE19976). All data collected and analyzed in the experiments adhere to the Minimal Information About a Microarray Experiment (MIAME) guidelines. 
     Statistical Analysis 
     Prior to statistical analysis, the mean intensity was computed for each probeset and the lowest 20% were removed, leaving a total of 26,626 probesets (genes). A Bayesian moderated t-test was applied to identify differentially expressed genes between P-F and N-SL using the ‘limma’ (linear models for microarray analysis) package from BioConductor. The Benjamini-Hochberg false discovery rate (FDR) procedure was applied to correct for multiple testing. The inverse log of the absolute log 2 fold change (FC) generated by ‘limma’ was used to determine the FC between P-F and N-SL groups, with the direction of change indicated by the sign. Further visualisation of the data using heatmaps and hierarchical clustering was performed using the TMeV4 software. 
     Gene-set analysis methods (GSEA) are as previously described (for example by Subramaniam A et al in PNAS 2005; 102:15545-50; and Nat Genet. 2003; 34: 244-5), and were performed using web-based GSEA software, such as is available from the Broad Institute (MIT and Harvard). 
     qPCR validation 
     For quantitative real-time PCR, complementary DNA was synthesized from 200 ng DNA-free RNA using the random priming High-Capacity cDNA Archive kit (Applied Biosystems) for all patients. Quantitative rt-PCR (qPCR) was performed using the Applied Biosystems 7500 Fast Real-Time PCR system following the manufacturer&#39;s instructions. Five random genes were selected for validation using SybrGreen gene expression assays (Applied Biosystems), based on their relative expression in the groups. Two genes (TBP-TATA binding protein and HPRT—hypoxanthine phosphoribosyl-transferase 1) were chosen as endogenous controls for the normalization of all target genes as they were consistently expressed in microarray samples and not significantly different between the groups. Samples were run in triplicate along with a standard curve, to obtain reaction efficiency values. Data were then analyzed using standard methods. 
     Results 
     Patient Demographics 
     Clinical features of patients are as follows: Average age in the N-SL group was 45.1 (SD 8.5) years, and 52.0 (SD 11.6) years in P-F group; serum ACE was 64.1 (SD 10.8) and 85.1 (SD 41.5) U/1 respectively; p=0.2 (Student t test); and circulating lymphocyte count were 1.07 (SD 0.43)×10̂9/1 and 0.79 (SD 0.50)×10̂9/1 respectively, p=0.2 (Student t test). Although there was no statistical difference between the two groups for serum ACE levels and lymphocyte count; the trends in these parameters and the pulmonary function tests between the P-F and N-SL groups (worse in the P-F group) are in keeping with the clinical characteristic of symptomatic and progressive disease. 
     Histology of all samples (paired with samples that were submitted for RNA extraction) showed non-caseating granuloma, indicating that lung tissue around active lesions was obtained. 
     Quality Control of Samples from Transbronchial Biopsies 
     We obtained between 0.6 to 3 mcg of RNA per patient, with no evidence of degradation ( FIG. 3A ), or significant difference in quality between the eight biopsy samples in the first set. In the second set, one patient had a RIN value of less than 6.5 and this sample was excluded. There was a strong positive correlation between mean gene intensity in each group, as would be expected if the majority of genes are not differentially expressed ( FIG. 3B ), and there was no systematic difference in the distribution of fluorescence intensity on the Gene Chips used ( FIG. 3C ). There was also good concordance between qPCR and microarray data in the trend of change between N-SL and P-F groups for our randomly selected subset of genes ( FIG. 3D ). 
     Since there were no systematic technical difference between the two sets of patients, analyses were performed, first, on the two sets of patients independently (ie 4 N-SL vs 4 P-F patients in Set 1; and 4 N-SL vs 3 P-F in Set 2), then as a combined cohort of 8 N-SL and 7 P-F patients. Analysis of the combined dataset of 8 N-SL and 7 P-F patients is reported here; though highly similar results were obtained when the two sets of patients were considered independently. 
     Differentially Expressed Genes in Lungs from Self-Limiting and Progressive—Fibrotic Patient Groups. 
     We found 334 differentially expressed genes (listed in Table 1) between the two groups of patients at a significance threshold of p&lt;0.01 (Bayesian moderated t test, unadjusted p value;  FIG. 1A ). The vast majority of these genes ( 279 ) were up-regulated in the progressive-fibrotic group compared to self-limiting patients. The presence of a clear set of genes showing differential expression suggests the possibility of using these genes as part of a signature profile to discriminate between these two groups of patients and eventually to predict patients that would fall into the progressive-fibrotic group. That is, the genes listed in Table 1 represent a gene set with potential to discriminate between progressive and self-limiting sarcoidosis. 
     Genes over-expressed in lungs of progressive-fibrotic compared to nodular, self-limiting pulmonary sarcoidosis comprise predominantly genes related to immune activation and host defence. 
     Unrestricted comparisons of very large numbers of variables between two groups introduce the problem of multiple testing, where the chance of making a Type I error (falsely identifying single genes as differentially expressed) is increased. In addition, relevant sets of genes can be lost to identification because the differences are modest relative to the noise inherent to the microarray technology. One method of overcoming these issues is to compare the groups of genes using predefined, biologically meaningful sets of gene. For this, we use Gene-Set Enrichment Analysis (GSEA) to evaluate whether sets of genes, grouped together by biological processes, as defined in Gene Ontology (GO) (24,25) are enriched (over-represented) among the differentially expressed genes in the gene list generated when comparing P-F and N-SL. 
     We found almost no enrichment of gene sets in genes up-regulated in the self-limiting group (only two-histone modification gene set and covalent chromatin modification gene set), but very large numbers of gene sets were highly significantly enriched among genes up-regulated in the progressive-fibrotic group [114 groups with FDR q value&lt;0.01; and top 43 categories q&lt;0.0001) (Table 2)]. In a higher level of evaluation, the genes within the gene-set that contribute most highly to the enrichment are extracted since these are the genes most likely to participate in the biological process within that gene-set. This subset is known as the ‘leading-edge’ genes. A graphical representation of GSEA results for the five most significant GO-based gene-sets is shown in  FIG. 2A . Due to the hierarchical nature of the gene ontology, GSEA results can include several closely related categories. Based on the overlap among leading edge genes and the GO hierarchy, the 114 gene-sets with FDR q values&lt;0.01 were grouped into 10 major categories ( FIG. 2B  and Table 5). This analysis showed that specific genes predominantly associated with immune activity are induced in the progressive-fibrotic group compared to the self-limiting group. This is also the case when the two sets of patients are analyzed sequentially (independent of each other). In particular, genes involved in leukocyte activation and differentiation, and cytokine production were over-expressed in P-F patients compared to the N-SL group. Other major processes that were found to be up-regulated in the P-F group included intracellular signaling (NFKB and JAK-STAT cascades) and categories related to cell life (apoptosis, cell cycle, cell proliferation and homeostasis) ( FIG. 2B  and Table 5). Taken together, these results suggest that immune activation is stronger in the P-F group relative to N-SL patients; and that the upregulated genes shown in  FIG. 1A  belong to biologically relevant gene-sets. 
     DISCUSSION 
     This study has shown that genes upregulated in lung samples obtained from patients with progressive-fibrotic sarcoidosis, compared to self-limiting disease, comprised predominantly genes involved in host defence and immune responses. Although the number of patients in the study relatively small, (though not so for microarray studies), one strength is the reproducibility of the findings in two separate and independent studies performed sequentially. 
     These findings are derived from a powerful analytical approach, which assesses the differential expression of sets of biologically-relevant genes rather than individual transcripts. This is an important distinction in all studies, but particularly relevant where smaller sample sizes are involved since the signal to noise ratio of the array data may lead to false conclusions about individual gene expression values. In addition, very few genes act in isolation and complex genetic diseases like sarcoidosis are likely to be caused by groups of functionally related genes that affect immunological processes or pathways. 
     One potential limitation to interpretation of the data is that, although patients from both groups were bronchoscoped at active phases of their disease (the N-SL group had nodularity on HRCT and in five of the eight patients, lymphopenia), the P-F group may have been sampled at a more active point. This is consequent of our attempt to capture and compare two divergent groups of patients with different disease severity, and patients with more severe disease may also have presented with more active disease. Thus, the comparison may encapsulate both disease severity (intended) and disease activity (unintended). This could explain the upregulation of immune response genes observed in the P-F group. 
     In this study, we also do not have the full composition of the cellular infiltrate to the respiratory tract. Routine clinical analyses indicated that bronchoalveolar fluid from all patients showed a lymphocytosis but comprehensive flow cytometry phenotyping of cells and their proportions were not undertaken. In retrospect, this may have been a useful adjunct to the study since it would further characterise the patients and their lung disease. 
     We have shown is that it is possible to use standard clinical procedures to obtain high quality RNA suitable for microarray analysis from lung biopsies, and these results set a precedence and platform for translation to a clinical practice-enhancing tool. 
     In summary, this study provides insight into the aetio-pathology of progressive-fibrotic sarcoidosis, pointing to a persistent T cell response as the cause of chronic disease rather than genes involved in fibrogenesis. It also shows that gene array expression profiling of samples obtained using a routine clinical tool can detect a set of genes that differentiate two classes of patients with pulmonary sarcoidosis which stands up to testing using biologically relevant categories of genes. 
     Tables 
       
     
       
         
           
               
               
               
               
             
               
                 TABLE 1 
               
               
                   
               
               
                 FC 
                 P. Value 
                 Gene. Title 
                 Gene. Symbol 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
            
               
                 Up regulated 
               
            
           
           
               
               
               
               
            
               
                 3.995 
                 0.009 
                 major histocompatibility complex, class II, DR beta 5 
                 HLA-DRB5 
               
               
                 2.915 
                 0.009 
                 sorting nexin 10 
                 SNX10 
               
               
                 2.798 
                 0.008 
                 C-type lectin domain family 4, member E 
                 CLEC4E 
               
               
                 2.396 
                 0.003 
                 SLAM family member 8 /// chromosome 1 open reading frame 204 
                 SLAMF8 /// 
               
               
                   
                   
                   
                 C1orf204 
               
               
                 2.340 
                 0.006 
                 C-type lectin domain family 6, member A 
                 CLEC6A 
               
               
                 2.322 
                 0.006 
                 immunoglobulin superfamily, member 6 
                 IGSF6 
               
               
                 2.230 
                 0.009 
                 SLAM family member 7 
                 SLAMF7 
               
               
                 2.225 
                 0.003 
                 formyl peptide receptor 3 
                 FPR3 
               
               
                 2.223 
                 0.004 
                 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 
                 ITGB2 
               
               
                 2.203 
                 0.006 
                 chromosome 17 open reading frame 87 
                 C17orf87 
               
               
                 2.183 
                 0.002 
                 interferon regulatory factor 8 
                 IRF8 
               
               
                 2.114 
                 0.009 
                 guanylate binding protein 5 
                 GBP5 
               
               
                 2.107 
                 0.004 
                 integrin, alpha X (complement component 3 receptor 4 subunit) 
                 ITGAX 
               
               
                 2.076 
                 0.004 
                 hemopoietic cell kinase 
                 HCK 
               
               
                 2.065 
                 0.001 
                 serpin peptidase inhibitor, clade E (nexin, plasminogen activator 
                 SERPINE1 
               
               
                   
                   
                 inhibitor type 1), member 1 
               
               
                 2.035 
                 0.005 
                 interleukin 10 receptor, alpha 
                 IL10RA 
               
               
                 2.032 
                 0.008 
                 interleukin 2 receptor, gamma (severe combined immunodeficiency) 
                 IL2RG 
               
               
                 2.021 
                 0.000 
                 ribonuclease, RNase A family, k6 
                 RNASE6 
               
               
                 2.009 
                 0.009 
                 CD180 molecule 
                 CD180 
               
               
                 1.993 
                 0.003 
                 FYN binding protein (FYB-120/130) 
                 FYB 
               
               
                 1.990 
                 0.006 
                 regulator of G-protein signaling 1 
                 RGS1 
               
               
                 1.989 
                 0.004 
                 replication factor C (activator 1) 1, 145 kDa 
                 RFC1 
               
               
                 1.978 
                 0.001 
                 lymphocyte antigen 96 
                 LY96 
               
               
                 1.948 
                 0.003 
                 fermitin family homolog 3 ( Drosophila ) 
                 FERMT3 
               
               
                 1.945 
                 0.009 
                 integrin, alpha M (complement component 3 receptor 3 subunit) 
                 ITGAM 
               
               
                 1.936 
                 0.004 
                 macrophage expressed 1 
                 MPEG1 
               
               
                 1.905 
                 0.003 
                 early growth response 2 
                 EGR2 
               
               
                 1.895 
                 0.001 
                 suppressor of cytokine signaling 3 
                 SOCS3 
               
               
                 1.878 
                 0.007 
                 jun B proto-oncogene 
                 JUNB 
               
               
                 1.869 
                 0.006 
                 major histocompatibility complex, class II, DQ beta 1 
                 HLA-DQB1 
               
               
                 1.863 
                 0.001 
                 solute carrier family 15, member 3 
                 SLC15A3 
               
               
                 1.833 
                 0.003 
                 neutrophil cytosolic factor 1 /// similar to Neutrophil cytosol factor 1 
                 NCF1 /// 
               
               
                   
                   
                 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil 
                 LOC648998 /// 
               
               
                   
                   
                 oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic 
                 NCF1C /// 
               
               
                   
                   
                 granulomatous disease protein) (NOXO2) /// neutrophil cytosolic 
                 NCF1B 
               
               
                   
                   
                 factor 1C pseudogene /// neutrophil cytosolic factor 1B pseudogene 
               
               
                 1.833 
                 0.006 
                 carboxypeptidase, vitellogenic-like 
                 CPVL 
               
               
                 1.833 
                 0.006 
                 C-type lectin domain family 7, member A 
                 CLEC7A 
               
               
                 1.830 
                 0.007 
                 membrane-associated ring finger (C3HC4) 1 
                 Mar-01 
               
               
                 1.817 
                 0.003 
                 purinergic receptor P2Y, G-protein coupled, 13 
                 P2RY13 
               
               
                 1.816 
                 0.001 
                 chromosome 6 open reading frame 150 
                 C6orf150 
               
               
                 1.816 
                 0.003 
                 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte- 
                 CSF2RB 
               
               
                   
                   
                 macrophage) 
               
               
                 1.815 
                 0.005 
                 hepatitis A virus cellular receptor 2 
                 HAVCR2 
               
               
                 1.800 
                 0.003 
                 myosin IF 
                 MYO1F 
               
               
                 1.797 
                 0.004 
                 colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte- 
                 CSF2RA 
               
               
                   
                   
                 macrophage) 
               
               
                 1.793 
                 0.002 
                 paired immunoglobin-like type 2 receptor alpha 
                 PILRA 
               
               
                 1.792 
                 0.003 
                 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, 
                 MTHFD2 
               
               
                   
                   
                 methenyltetrahydrofolate cyclohydrolase 
               
               
                 1.785 
                 0.009 
                 superoxide dismutase 2, mitochondrial 
                 SOD2 
               
               
                 1.779 
                 0.001 
                 hematopoietic cell-specific Lyn substrate 1 
                 HCLS1 
               
               
                 1.772 
                 0.003 
                 alanyl (membrane) aminopeptidase 
                 ANPEP 
               
               
                 1.772 
                 0.001 
                 colony stimulating factor 1 receptor 
                 CSF1R 
               
               
                 1.755 
                 0.005 
                 chromosome 1 open reading frame 38 
                 C1orf38 
               
               
                 1.748 
                 0.006 
                 proline-serine-threonine phosphatase interacting protein 2 
                 PSTPIP2 
               
            
           
           
               
            
               
                 Down regulated 
               
            
           
           
               
               
               
               
            
               
                 1.881 
                 0.000 
                 olfactory receptor, family 2, subfamily A, member 7 /// olfactory 
                 OR2A7 /// 
               
               
                   
                   
                 receptor, family 2, subfamily A, member 4 /// similar to rho guanine 
                 OR2A4 /// 
               
               
                   
                   
                 nucleotide exchange factor 5 
                 LOC728377 
               
               
                 1.872 
                 0.005 
                 Prader-Willi/Angelman syndrome-5 /// small nuclear 
                 PAR5 /// SNRPN 
               
               
                   
                   
                 ribonucleoprotein polypeptide N /// small nucleolar RNA, C/D box 64 
                 /// SNORD64 /// 
               
               
                   
                   
                 /// paternally expressed transcript PAR-SN 
                 PAR-SN 
               
               
                 1.591 
                 0.000 
                 tubulin tyrosine ligase-like family, member 7 
                 TTLL7 
               
               
                 1.579 
                 0.005 
                 CTAGE family, member 4 /// CTAGE family, member 6 /// CTAGE 
                 CTAGE4 /// 
               
               
                   
                   
                 family member /// similar to CTAGE6 
                 CTAGE6 /// 
               
               
                   
                   
                   
                 LOC100142659 
               
               
                   
                   
                   
                 /// LOC441294 
               
               
                 1.528 
                 0.002 
                 chromosome 7 open reading frame 41 
                 C7orf41 
               
               
                 1.524 
                 0.002 
                 alcohol dehydrogenase, iron containing, 1 
                 ADHFE1 
               
               
                 1.498 
                 0.004 
                 family with sequence similarity 86, member A pseudogene 
                 hCG_1990547 
               
               
                 1.491 
                 0.003 
                 dpy-19-like 2 pseudogene 1 ( C. elegans ) 
                 DPY19L2P1 
               
               
                 1.464 
                 0.009 
                 EF-hand calcium binding domain 2 
                 EFCAB2 
               
               
                 1.439 
                 0.007 
                 RUN domain containing 2C /// RUN domain containing 2B 
                 RUNDC2C /// 
               
               
                   
                   
                   
                 RUNDC2B 
               
               
                 1.439 
                 0.004 
                 zinc finger, DBF-type containing 2 
                 ZDBF2 
               
               
                 1.432 
                 0.004 
                 multiple PDZ domain protein 
                 MPDZ 
               
               
                 1.422 
                 0.005 
                 spectrin repeat containing, nuclear envelope 1 
                 SYNE1 
               
               
                 1.421 
                 0.008 
                 syntaxin binding protein 4 
                 STXBP4 
               
               
                 1.419 
                 0.005 
                 thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) 
                 THRB 
               
               
                   
                   
                 oncogene homolog 2, avian) 
               
               
                 1.418 
                 0.004 
                 G protein-coupled receptor 125 
                 GPR125 
               
               
                 1.376 
                 0.000 
                 SRY (sex determining region Y)-box 5 
                 SOX5 
               
               
                 1.357 
                 0.003 
                 hypothetical protein LOC100127980 
                 LOC100127980 
               
               
                 1.353 
                 0.003 
                 Abelson helper integration site 1 
                 AHI1 
               
               
                 1.352 
                 0.005 
                 solute carrier family 26, member 5 (prestin) 
                 SLC26A5 
               
               
                 1.351 
                 0.007 
                 GLI-Kruppel family member HKR1 
                 HKR1 
               
               
                 1.334 
                 0.004 
                 InaD-like ( Drosophila ) 
                 INADL 
               
               
                 1.332 
                 0.009 
                 KIAA1328 
                 KIAA1328 
               
               
                 1.324 
                 0.003 
                 CDC42 binding protein kinase alpha (DMPK-like) 
                 CDC42BPA 
               
               
                 1.315 
                 0.005 
                 destrin (actin depolymerizing factor) 
                 DSTN 
               
               
                 1.312 
                 0.004 
                 WD repeat domain 27 
                 WDR27 
               
               
                 1.311 
                 0.007 
                 CMT1A duplicated region transcript 4 /// family with sequence 
                 CDRT4 /// 
               
               
                   
                   
                 similarity 18, member B2 
                 FAM18B2 
               
               
                 1.311 
                 0.005 
                 furry homolog ( Drosophila ) 
                 FRY 
               
               
                 1.307 
                 0.009 
                 BMS1 pseudogene 4 /// BMS1 pseudogene 5 /// ArfGAP with GTPase 
                 BMS1P4 /// 
               
               
                   
                   
                 domain, ankyrin repeat and PH domain 10 /// hypothetical 
                 BMS1P5 /// 
               
               
                   
                   
                 LOC399753 
                 AGAP10 /// 
               
               
                   
                   
                   
                 RP11-144G6.7 
               
               
                 1.297 
                 0.001 
                 zinc finger protein 507 
                 ZNF507 
               
               
                 1.275 
                 0.008 
                 oral-facial-digital syndrome 1 
                 OFD1 
               
               
                 1.267 
                 0.002 
                 kelch-like 23 ( Drosophila ) /// phosphatase, orphan 2 
                 KLHL23 /// 
               
               
                   
                   
                   
                 PHOSPHO2 
               
               
                 1.263 
                 0.008 
                 zinc finger protein 608 
                 ZNF608 
               
               
                 1.263 
                 0.008 
                 golgi autoantigen, golgin subfamily a, 2-like 1 
                 GOLGA2L1 
               
               
                 1.261 
                 0.006 
                 chromosome 6 open reading frame 124 
                 C6orf124 
               
               
                 1.255 
                 0.003 
                 cubilin (intrinsic factor-cobalamin receptor) 
                 CUBN 
               
               
                 1.255 
                 0.001 
                 protein kinase, AMP-activated, beta 2 non-catalytic subunit 
                 PRKAB2 
               
               
                 1.249 
                 0.003 
                 bone morphogenetic protein receptor, type IA 
                 BMPR1A 
               
               
                 1.239 
                 0.007 
                 zinc finger protein 285A 
                 ZNF285A 
               
               
                 1.235 
                 0.005 
                 olfactory receptor, family 7, subfamily E, member 13 pseudogene 
                 OR7E13P 
               
               
                 1.234 
                 0.009 
                 chromosome X open reading frame 42 
                 CXorf42 
               
               
                 1.230 
                 0.009 
                 olfactory receptor, family 51, subfamily I, member 2 
                 OR51I2 
               
               
                 1.220 
                 0.005 
                 bone morphogenetic protein receptor, type IA 
                 BMPR1A 
               
               
                 1.213 
                 0.001 
                 melanoma antigen family A, 5 
                 MAGEA5 
               
               
                 1.210 
                 0.010 
                 inhibitor of growth family, member 5 
                 ING5 
               
               
                 1.209 
                 0.007 
                 olfactory receptor, family 2, subfamily C, member 1 
                 OR2C1 
               
               
                 1.206 
                 0.009 
                 zinc finger protein 512 
                 ZNF512 
               
               
                 1.202 
                 0.008 
                 zinc finger protein 250 
                 ZNF250 
               
               
                 1.186 
                 0.006 
                 Sec61 alpha 2 subunit ( S. cerevisiae ) 
                 SEC61A2 
               
               
                 1.180 
                 0.010 
                 family with sequence similarity 27-like 
                 FAM27L 
               
               
                 1.178 
                 0.006 
                 chromodomain helicase DNA binding protein 6 
                 CHD6 
               
               
                 1.176 
                 0.008 
                 chromosome 2 open reading frame 14 /// hypothetical LOC440905 /// 
                 C2orf14 /// 
               
               
                   
                   
                 Uncharacterized protein C2orf14-like 1 /// Uncharacterized protein 
                 LOC440905 /// 
               
               
                   
                   
                 C2orf14-like 2 /// hypothetical protein LOC440910 
                 LOC646802 /// 
               
               
                   
                   
                   
                 LOC100128270 
               
               
                   
                   
                   
                 /// LOC440910 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
               
                   
               
               
                 NAMEs of GENE SET defined by Gene Ontology 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
            
               
                 IMMUNE_SYSTEM_PROCESS 
               
               
                 DEFENSE_RESPONSE 
               
               
                 IMMUNE 
               
               
                 LYMPHOCYTE_ACTIVATION 
               
               
                 LEUKOCYTE_ACTIVATION 
               
               
                 INFLAMMATORY_RESPONSE 
               
               
                 T_CELL_ACTIVATION 
               
               
                 REGULATION_OF_IMMUNE_SYSTEM_PROCESS 
               
               
                 CELL_ACTIVATION 
               
               
                 RESPONSE_TO_BIOTIC_STIMULUS 
               
               
                 REGULATION_OF_LYMPHOCYTE_ACTIVATION 
               
               
                 RESPONSE_TO_OTHER_ORGANISM 
               
               
                 RESPONSE_TO_WOUNDING 
               
               
                 POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 
               
               
                 RESPONSE_TO_EXTERNAL_STIMULUS 
               
               
                 POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS 
               
               
                 CELLULAR_DEFENSE_RESPONSE 
               
               
                 REGULATION_OF_T_CELL_ACTIVATION 
               
               
                 RESPONSE_TO_VIRUS 
               
               
                 MULTI_ORGANISM_PROCESS 
               
               
                 IMMUNE_SYSTEM_DEVELOPMENT 
               
               
                 ADAPTIVE_IMMUNE_RESPONSE 
               
               
                 POSITIVE_REGULATION_OF_LYMPHOCYTE_ACTIVATION 
               
               
                 HEMOPOIETIC_OR_LYMPHOID_ORGAN_DEVELOPMENT 
               
               
                 ADAPTIVE_IMMUNE_RESPONSE_GO_0002460 
               
               
                 HEMOPOIESIS 
               
               
                 LEUKOCYTE_DIFFERENTIATION 
               
               
                 CATION_HOMEOSTASIS 
               
               
                 BEHAVIOR 
               
               
                 I_KAPPAB_KINASE_NF_KAPPAB_CASCADE 
               
               
                 LYMPHOCYTE_DIFFERENTIATION 
               
               
                 POSITIVE_REGULATION_OF_T_CELL_ACTIVATION 
               
               
                 HOMEOSTATIC_PROCESS 
               
               
                 ION_HOMEOSTASIS 
               
               
                 CELLULAR_CATION_HOMEOSTASIS 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 3 
               
               
                   
               
               
                 Gene Name 
                 Full Gene Name 
                 t Value 
                 P. Value 
                 adj. P. Val 
                 FC 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 PLA2G7 
                 phospholipase A2, group VII (platelet- 
                 −4.02 
                 0.003 
                 0.999169 
                 6.21 
               
               
                   
                 activating factor acetylhydrolase, plasma) 
               
               
                 MMP9 
                 matrix metallopeptidase 9 
                 −3.98 
                 0.004 
                 0.999169 
                 5.36 
               
               
                 ADAMDEC1 
                 ADAM-like, decysin 1 
                 −3.67 
                 0.006 
                 0.999169 
                 4.14 
               
               
                 LILRB4 
                 leukocyte immunoglobulin-like receptor, 
                 −5.29 
                 0.001 
                 0.999169 
                 3.57 
               
               
                   
                 subfamily B (with TM and ITIM domains), 
               
               
                   
                 member 4 
               
               
                 SLAMF8 
                 SLAM family member 8 
                 −4.43 
                 0.002 
                 0.999169 
                 3.19 
               
               
                 ITGAX 
                 integrin, alpha X (complement component 3 
                 −4.72 
                 0.001 
                 0.999169 
                 2.91 
               
               
                   
                 receptor 4 subunit) 
               
               
                 ITGB2 
                 integrin, beta 2 (complement component 3 
                 −3.86 
                 0.004 
                 0.999169 
                 2.84 
               
               
                   
                 receptor 3 and 4 subunit) 
               
               
                 SLAMF7 
                 SLAM family member 7 
                 −4.29 
                 0.002 
                 0.999169 
                 2.76 
               
               
                 FERMT3 
                 fermitin family homolog 3 ( Drosophila ) 
                 −3.69 
                 0.005 
                 0.999169 
                 2.55 
               
               
                 RASSF4 
                 Ras association (RalGDS/AF-6) domain 
                 −3.47 
                 0.008 
                 0.999169 
                 2.53 
               
               
                   
                 family member 4 
               
               
                 TMEM176A 
                 transmembrane protein 176A 
                 −4.11 
                 0.003 
                 0.999169 
                 2.52 
               
               
                 APOE 
                 apolipoprotein E 
                 −3.57 
                 0.007 
                 0.999169 
                 2.34 
               
               
                 C1QC 
                 complement component 1, q subcomponent, C 
                 −3.85 
                 0.004 
                 0.999169 
                 2.31 
               
               
                   
                 chain 
               
               
                 FADS1 
                 fatty acid desaturase 1 
                 −3.52 
                 0.007 
                 0.999169 
                 2.27 
               
               
                 CAPG 
                 capping protein (actin filament), gelsolin-like 
                 −3.41 
                 0.008 
                 0.999169 
                 2.27 
               
               
                 GM2A 
                 GM2 ganglioside activator 
                 −3.52 
                 0.007 
                 0.999169 
                 2.23 
               
               
                 PLA2G2D 
                 phospholipase A2, group IID 
                 −3.39 
                 0.009 
                 0.999169 
                 2.21 
               
               
                 CR1 
                 complement component (3b/4b) receptor 1 
                 −3.99 
                 0.003 
                 0.999169 
                 2.19 
               
               
                   
                 (Knops blood group) 
               
               
                 GRN 
                 granulin 
                 −3.51 
                 0.007 
                 0.999169 
                 2.19 
               
               
                 MYO1F 
                 myosin IF 
                 −3.69 
                 0.005 
                 0.999169 
                 2.18 
               
               
                 TNFRSF9 
                 tumor necrosis factor receptor superfamily, 
                 −7.27 
                 0.000 
                 0.999169 
                 2.17 
               
               
                   
                 member 9 
               
               
                 SLC15A3 
                 solute carrier family 15, member 3 
                 −3.96 
                 0.004 
                 0.999169 
                 2.15 
               
               
                 LGMN 
                 legumain 
                 −3.74 
                 0.005 
                 0.999169 
                 2.14 
               
               
                 SOD2 
                 superoxide dismutase 2, mitochondrial 
                 −3.97 
                 0.004 
                 0.999169 
                 2.13 
               
               
                 LILRB1 
                 leukocyte immunoglobulin-like receptor, 
                 −4.10 
                 0.003 
                 0.999169 
                 2.12 
               
               
                   
                 subfamily B (with TM and ITIM domains), 
               
               
                   
                 member 1 
               
               
                 CYP27A1 
                 cytochrome P450, family 27, subfamily A, 
                 −3.38 
                 0.009 
                 0.999169 
                 2.05 
               
               
                   
                 polypeptide 1 
               
               
                 KRT7 
                 keratin 7 
                 −4.77 
                 0.001 
                 0.999169 
                 2.01 
               
               
                 CXCL16 
                 chemokine (C—X—C motif) ligand 16 
                 −3.97 
                 0.004 
                 0.999169 
                 2.00 
               
               
                 EMILIN2 
                 elastin microfibril interfacer 2 
                 −3.45 
                 0.008 
                 0.999169 
                 1.99 
               
               
                 EMR2 
                 egf-like module containing, mucin-like, 
                 −3.90 
                 0.004 
                 0.999169 
                 1.98 
               
               
                   
                 hormone receptor-like 2 
               
               
                 UBD 
                 ubiquitin D 
                 −3.43 
                 0.008 
                 0.999169 
                 1.97 
               
               
                 PILRA 
                 paired immunoglobin-like type 2 receptor 
                 −3.78 
                 0.005 
                 0.999169 
                 1.97 
               
               
                   
                 alpha 
               
               
                 TNFAIP2 
                 tumor necrosis factor, alpha-induced protein 2 
                 −4.96 
                 0.001 
                 0.999169 
                 1.96 
               
               
                 CSF1R 
                 colony stimulating factor 1 receptor 
                 −4.64 
                 0.001 
                 0.999169 
                 1.96 
               
               
                 SERPINE1 
                 serpin peptidase inhibitor, clade E (nexin, 
                 −3.43 
                 0.008 
                 0.999169 
                 1.95 
               
               
                   
                 plasminogen activator inhibitor type 1), 
               
               
                   
                 member 1 
               
               
                 WARS 
                 tryptophanyl-tRNA synthetase 
                 −3.68 
                 0.006 
                 0.999169 
                 1.94 
               
               
                 S100A9 
                 S100 calcium binding protein A9 
                 −3.57 
                 0.007 
                 0.999169 
                 1.94 
               
               
                 CTSZ 
                 cathepsin Z 
                 −3.86 
                 0.004 
                 0.999169 
                 1.91 
               
               
                 TAP1 
                 transporter 1, ATP-binding cassette, sub- 
                 −4.20 
                 0.003 
                 0.999169 
                 1.91 
               
               
                   
                 family B (MDR/TAP) 
               
               
                 HMOX1 
                 heme oxygenase (decycling) 1 
                 −4.21 
                 0.003 
                 0.999169 
                 1.91 
               
               
                 TAP2 
                 transporter 2, ATP-binding cassette, sub- 
                 −4.37 
                 0.002 
                 0.999169 
                 1.86 
               
               
                   
                 family B (MDR/TAP) 
               
               
                 NR1H3 
                 nuclear receptor subfamily 1, group H, 
                 −3.82 
                 0.004 
                 0.999169 
                 1.86 
               
               
                   
                 member 3 
               
               
                 SOCS3 
                 suppressor of cytokine signaling 3 
                 −3.54 
                 0.007 
                 0.999169 
                 1.86 
               
               
                 PIK3AP1 
                 phosphoinositide-3-kinase adaptor protein 1 
                 −3.37 
                 0.009 
                 0.999169 
                 1.85 
               
               
                 MAN2B1 
                 mannosidase, alpha, class 2B, member 1 
                 −5.92 
                 0.000 
                 0.999169 
                 1.84 
               
               
                 TCN2 
                 transcobalamin II; macrocytic anemia 
                 −3.77 
                 0.005 
                 0.999169 
                 1.81 
               
               
                 NCF1 
                 neutrophil cytosolic factor 1 
                 −4.00 
                 0.003 
                 0.999169 
                 1.81 
               
               
                 IL17RA 
                 interleukin 17 receptor A 
                 −4.72 
                 0.001 
                 0.999169 
                 1.80 
               
               
                 TTYH3 
                 tweety homolog 3 ( Drosophila ) 
                 −3.91 
                 0.004 
                 0.999169 
                 1.80 
               
               
                 C10orf64 
                 chromosome 10 open reading frame 64 
                 −3.46 
                 0.008 
                 0.999169 
                 1.79 
               
               
                 CD4 
                 CD4 molecule 
                 −4.60 
                 0.001 
                 0.999169 
                 1.78 
               
               
                 PLAU 
                 plasminogen activator, urokinase 
                 −3.43 
                 0.008 
                 0.999169 
                 1.76 
               
               
                 ARPC1B 
                 actin related protein 2/3 complex, subunit 1B, 
                 −3.78 
                 0.005 
                 0.999169 
                 1.75 
               
               
                   
                 41 kDa 
               
               
                 IL2RA 
                 interleukin 2 receptor, alpha 
                 −4.15 
                 0.003 
                 0.999169 
                 1.74 
               
               
                 TYMP 
                 thymidine phosphorylase 
                 −5.11 
                 0.001 
                 0.999169 
                 1.73 
               
               
                 SCARB1 
                 scavenger receptor class B, member 1 
                 −3.38 
                 0.009 
                 0.999169 
                 1.73 
               
               
                 WDFY4 
                 WDFY family member 4 
                 −3.62 
                 0.006 
                 0.999169 
                 1.72 
               
               
                 KCNAB2 
                 potassium voltage-gated channel, shaker- 
                 −3.95 
                 0.004 
                 0.999169 
                 1.72 
               
               
                   
                 related subfamily, beta member 2 
               
               
                 CTSB 
                 cathepsin B 
                 −4.44 
                 0.002 
                 0.999169 
                 1.71 
               
               
                 RND1 
                 Rho family GTPase 1 
                 −3.71 
                 0.005 
                 0.999169 
                 1.71 
               
               
                 TPP1 
                 tripeptidyl peptidase I 
                 −3.37 
                 0.009 
                 0.999169 
                 1.71 
               
               
                 PLD3 
                 phospholipase D family, member 3 
                 −4.31 
                 0.002 
                 0.999169 
                 1.69 
               
               
                 FGD2 
                 FYVE, RhoGEF and PH domain containing 2 
                 −3.79 
                 0.005 
                 0.999169 
                 1.69 
               
               
                 C5orf20 
                 chromosome 5 open reading frame 20 
                 −4.10 
                 0.003 
                 0.999169 
                 1.68 
               
               
                 PTPRJ 
                 protein tyrosine phosphatase, receptor type, J 
                 −4.53 
                 0.002 
                 0.999169 
                 1.67 
               
               
                 TAPBP 
                 TAP binding protein (tapasin) 
                 −3.50 
                 0.007 
                 0.999169 
                 1.65 
               
               
                 LILRB2 
                 leukocyte immunoglobulin-like receptor, 
                 −3.63 
                 0.006 
                 0.999169 
                 1.64 
               
               
                   
                 subfamily B (with TM and ITIM domains), 
               
               
                   
                 member 2 
               
               
                 IL21R 
                 interleukin 21 receptor 
                 −5.73 
                 0.000 
                 0.999169 
                 1.63 
               
               
                 CCNYL1 
                 cyclin Y-like 1 
                 −3.32 
                 0.010 
                 0.999169 
                 1.62 
               
               
                 SIGLEC10 
                 sialic acid binding Ig-like lectin 10 
                 −5.31 
                 0.001 
                 0.999169 
                 1.62 
               
               
                 ALPL 
                 alkaline phosphatase, liver/bone/kidney 
                 −3.40 
                 0.008 
                 0.999169 
                 1.61 
               
               
                 NFAM1 
                 NFAT activating protein with ITAM motif 1 
                 −3.71 
                 0.005 
                 0.999169 
                 1.60 
               
               
                 CYP27B1 
                 cytochrome P450, family 27, subfamily B, 
                 −4.88 
                 0.001 
                 0.999169 
                 1.60 
               
               
                   
                 polypeptide 1 
               
               
                 MAFB 
                 v-maf musculoaponeurotic fibrosarcoma 
                 −3.90 
                 0.004 
                 0.999169 
                 1.60 
               
               
                   
                 oncogene homolog B (avian) 
               
               
                 COTL1 
                 coactosin-like 1 ( Dictyostelium ) 
                 −3.69 
                 0.005 
                 0.999169 
                 1.59 
               
               
                 SLC37A2 
                 solute carrier family 37 (glycerol-3-phosphate 
                 −3.70 
                 0.005 
                 0.999169 
                 1.59 
               
               
                   
                 transporter), member 2 
               
               
                 P76 
                 mannose-6-phosphate protein p76 
                 −3.52 
                 0.007 
                 0.999169 
                 1.59 
               
               
                 IL1R2 
                 interleukin 1 receptor, type II 
                 −5.20 
                 0.001 
                 0.999169 
                 1.58 
               
               
                 G6PD 
                 glucose-6-phosphate dehydrogenase 
                 −3.75 
                 0.005 
                 0.999169 
                 1.58 
               
               
                 SLC24A6 
                 solute carrier family 24 
                 −3.36 
                 0.009 
                 0.999169 
                 1.57 
               
               
                   
                 (sodium/potassium/calcium exchanger), 
               
               
                   
                 member 6 
               
               
                 VAC14 
                 Vac14 homolog ( S. cerevisiae ) 
                 −4.04 
                 0.003 
                 0.999169 
                 1.57 
               
               
                 PSAP 
                 prosaposin (variant Gaucher disease and 
                 −3.71 
                 0.005 
                 0.999169 
                 1.57 
               
               
                   
                 variant metachromatic leukodystrophy) 
               
               
                 ACP2 
                 acid phosphatase 2, lysosomal 
                 −4.28 
                 0.002 
                 0.999169 
                 1.55 
               
               
                 HLA-F 
                 major histocompatibility complex, class I, F 
                 −3.34 
                 0.009 
                 0.999169 
                 1.54 
               
               
                 TCIRG1 
                 T-cell, immune regulator 1, ATPase, H+ 
                 −3.83 
                 0.004 
                 0.999169 
                 1.53 
               
               
                   
                 transporting, lysosomal V0 subunit A3 
               
               
                 CD74 
                 CD74 molecule, major histocompatibility 
                 −4.11 
                 0.003 
                 0.999169 
                 1.53 
               
               
                   
                 complex, class II invariant chain 
               
               
                 GPR132 
                 G protein-coupled receptor 132 
                 −3.45 
                 0.008 
                 0.999169 
                 1.51 
               
               
                 IGF2R 
                 insulin-like growth factor 2 receptor 
                 −3.38 
                 0.009 
                 0.999169 
                 1.51 
               
               
                 MMP14 
                 matrix metallopeptidase 14 (membrane- 
                 −3.61 
                 0.006 
                 0.999169 
                 1.51 
               
               
                   
                 inserted) 
               
               
                 SRXN1 
                 sulfiredoxin 1 homolog ( S. cerevisiae ) 
                 −3.59 
                 0.006 
                 0.999169 
                 1.51 
               
               
                 RHBDF2 
                 rhomboid 5 homolog 2 ( Drosophila ) 
                 −4.21 
                 0.003 
                 0.999169 
                 1.50 
               
               
                 TRGV3 
                 T cell receptor gamma variable 3 
                 −3.56 
                 0.007 
                 0.999169 
                 1.50 
               
               
                 PTAFR 
                 platelet-activating factor receptor 
                 −3.55 
                 0.007 
                 0.999169 
                 1.50 
               
               
                 NBEAL2 
                 neurobeachin-like 2 
                 −3.32 
                 0.010 
                 0.999169 
                 1.49 
               
               
                 IL4I1 
                 interleukin 4 induced 1 
                 −3.79 
                 0.005 
                 0.999169 
                 1.49 
               
               
                 GNS 
                 glucosamine (N-acetyl)-6-sulfatase 
                 −3.30 
                 0.010 
                 0.999169 
                 1.47 
               
               
                   
                 (Sanfilippo disease IIID) 
               
               
                 MKI67 
                 antigen identified by monoclonal antibody Ki- 
                 −4.00 
                 0.003 
                 0.999169 
                 1.47 
               
               
                   
                 67 
               
               
                 OAS3 
                 2′-5′-oligoadenylate synthetase 3, 100 kDa 
                 −3.64 
                 0.006 
                 0.999169 
                 1.47 
               
               
                 DTX3L 
                 deltex 3-like ( Drosophila ) 
                 −3.46 
                 0.008 
                 0.999169 
                 1.47 
               
               
                 C5AR1 
                 complement component 5a receptor 1 
                 −3.67 
                 0.006 
                 0.999169 
                 1.46 
               
               
                 GPR68 
                 G protein-coupled receptor 68 
                 −4.06 
                 0.003 
                 0.999169 
                 1.46 
               
               
                 MGAT1 
                 mannosyl (alpha-1,3-)-glycoprotein beta-1,2- 
                 −3.98 
                 0.004 
                 0.999169 
                 1.46 
               
               
                   
                 N-acetylglucosaminyltransferase 
               
               
                 DPP9 
                 dipeptidyl-peptidase 9 
                 −3.51 
                 0.007 
                 0.999169 
                 1.46 
               
               
                 FYB 
                 FYN binding protein (FYB-120/130) 
                 −3.58 
                 0.006 
                 0.999169 
                 1.46 
               
               
                 PI4K2A 
                 phosphatidylinositol 4-kinase type 2 alpha 
                 −3.97 
                 0.004 
                 0.999169 
                 1.45 
               
               
                 AKIRIN2 
                 akirin 2 
                 −3.41 
                 0.008 
                 0.999169 
                 1.45 
               
               
                 LOC554223 
                 hypothetical LOC554223 
                 −3.37 
                 0.009 
                 0.999169 
                 1.44 
               
               
                 USP6 
                 ubiquitin specific peptidase 6 (Tre-2 oncogene 
                 −3.36 
                 0.009 
                 0.999169 
                 1.44 
               
               
                 RTN1 
                 reticulon 1 
                 −3.30 
                 0.010 
                 0.999169 
                 1.43 
               
               
                 E2F3 
                 E2F transcription factor 3 
                 −3.45 
                 0.008 
                 0.999169 
                 1.41 
               
               
                 MIER2 
                 mesoderm induction early response 1, family 
                 −3.46 
                 0.008 
                 0.999169 
                 1.40 
               
               
                   
                 member 2 
               
               
                 TBC1D2 
                 TBC1 domain family, member 2 
                 −3.37 
                 0.009 
                 0.999169 
                 1.39 
               
               
                 C19orf28 
                 chromosome 19 open reading frame 28 
                 −3.54 
                 0.007 
                 0.999169 
                 1.39 
               
               
                 ADA 
                 adenosine deaminase 
                 −3.45 
                 0.008 
                 0.999169 
                 1.38 
               
               
                 C19orf61 
                 chromosome 19 open reading frame 61 
                 −3.34 
                 0.009 
                 0.999169 
                 1.36 
               
               
                 ECOP 
                 EGFR-coamplified and overexpressed protein 
                 −3.40 
                 0.009 
                 0.999169 
                 1.35 
               
               
                 PIM1 
                 pim-1 oncogene 
                 −3.32 
                 0.010 
                 0.999169 
                 1.34 
               
               
                 MCM5 
                 minichromosome maintenance complex 
                 −3.42 
                 0.008 
                 0.999169 
                 1.33 
               
               
                   
                 component 5 
               
               
                 SLC25A12 
                 solute carrier family 25 (mitochondrial carrier, 
                 3.52 
                 0.007 
                 0.999169 
                 −3.64 
               
               
                   
                 Aralar), member 12 
               
               
                 PRG3 
                 proteoglycan 3 
                 3.45 
                 0.008 
                 0.999169 
                 −1.72 
               
               
                 DSTN 
                 destrin (actin depolymerizing factor) 
                 3.41 
                 0.008 
                 0.999169 
                 −1.70 
               
               
                 SOX5 
                 SRY (sex determining region Y)-box 5 
                 4.07 
                 0.003 
                 0.999169 
                 −1.65 
               
               
                 TBC1D8 
                 TBC1 domain family, member 8 
                 3.37 
                 0.009 
                 0.999169 
                 −1.60 
               
               
                 LOC349196 
                 hypothetical LOC349196 
                 3.37 
                 0.009 
                 0.999169 
                 −1.56 
               
               
                 METT5D1 
                 methyltransferase 5 domain containing 1 
                 3.80 
                 0.005 
                 0.999169 
                 −1.53 
               
               
                 DHX35 
                 DEAH (Asp-Glu-Ala-His) box polypeptide 35 
                 3.36 
                 0.009 
                 0.999169 
                 −1.48 
               
               
                 LOC134466 
                 hypothetical protein LOC134466 
                 3.47 
                 0.008 
                 0.999169 
                 −1.48 
               
               
                 LOC100127980 
                 hypothetical protein LOC100127980 
                 4.75 
                 0.001 
                 0.999169 
                 −1.46 
               
               
                 RP4-621O15.2 
                 hypothetical protein FLJ31401 
                 3.49 
                 0.007 
                 0.999169 
                 −1.46 
               
               
                 TTLL7 
                 tubulin tyrosine ligase-like family, member 7 
                 4.02 
                 0.003 
                 0.999169 
                 −1.43 
               
               
                 DPY19L2 
                 dpy-19-like 2 ( C. elegans ) 
                 3.33 
                 0.009 
                 0.999169 
                 −1.43 
               
               
                 NEGR1 
                 neuronal growth regulator 1 
                 3.57 
                 0.007 
                 0.999169 
                 −1.34 
               
               
                 PRUNE2 
                 prune homolog 2 ( Drosophila ) 
                 3.32 
                 0.010 
                 0.999169 
                 −1.34 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                 TABLE 4 
               
               
                   
               
               
                   
                 Size of 
                   
                 FDR 
               
               
                 Gene ontology-defined biological categories 
                 gene set 
                 NES 
                 q-val 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 IMMUNE_SYSTEM_PROCESS 
                 275 
                 −2.75 
                 0 
               
               
                 IMMUNE_RESPONSE 
                 192 
                 −2.75 
                 0 
               
               
                 DEFENSE_RESPONSE 
                 203 
                 −2.66 
                 0 
               
               
                 LOCOMOTORY_BEHAVIOR 
                 77 
                 −2.61 
                 0 
               
               
                 INFLAMMATORY_RESPONSE 
                 101 
                 −2.55 
                 0 
               
               
                 RESPONSE_TO_EXTERNAL_STIMULUS 
                 236 
                 −2.42 
                 0 
               
               
                 RESPONSE_TO_WOUNDING 
                 149 
                 −2.41 
                 0 
               
               
                 BEHAVIOR 
                 112 
                 −2.40 
                 0 
               
               
                 LYMPHOCYTE_ACTIVATION 
                 51 
                 −2.34 
                 0 
               
               
                 CELLULAR_DEFENSE_RESPONSE 
                 44 
                 −2.33 
                 0 
               
               
                 MULTI_ORGANISM_PROCESS 
                 113 
                 −2.29 
                 0 
               
               
                 CELL_ACTIVATION 
                 64 
                 −2.25 
                 2.0E−04 
               
               
                 RESPONSE_TO_BIOTIC_STIMULUS 
                 95 
                 −2.25 
                 1.9E−04 
               
               
                 RESPONSE_TO_OTHER_ORGANISM 
                 61 
                 −2.24 
                 1.7E−04 
               
               
                 HEMOPOIETIC_OR_LYMPHOID_ORGAN_DEVELOPMENT 
                 67 
                 −2.24 
                 1.6E−04 
               
               
                 IMMUNE_SYSTEM_DEVELOPMENT 
                 70 
                 −2.24 
                 1.5E−04 
               
               
                 HEMOPOIESIS 
                 66 
                 −2.23 
                 1.4E−04 
               
               
                 LEUKOCYTE_ACTIVATION 
                 58 
                 −2.23 
                 1.4E−04 
               
               
                 RAS_PROTEIN_SIGNAL_TRANSDUCTION 
                 61 
                 −2.22 
                 1.3E−04 
               
               
                 T_CELL_ACTIVATION 
                 36 
                 −2.20 
                 1.2E−04 
               
               
                 RESPONSE_TO_VIRUS 
                 37 
                 −2.18 
                 1.2E−04 
               
               
                 PROTEIN_KINASE_CASCADE 
                 257 
                 −2.16 
                 1.6E−04 
               
               
                 REGULATION_OF_DEVELOPMENTAL_PROCESS 
                 378 
                 −2.15 
                 1.6E−04 
               
               
                 REGULATION_OF_PROGRAMMED_CELL_DEATH 
                 302 
                 −2.14 
                 2.0E−04 
               
               
                 LIPID_TRANSPORT 
                 25 
                 −2.13 
                 2.0E−04 
               
               
                 INTRACELLULAR_SIGNALING_CASCADE 
                 568 
                 −2.13 
                 1.9E−04 
               
               
                 HOMEOSTATIC_PROCESS 
                 169 
                 −2.13 
                 1.8E−04 
               
               
                 REGULATION_OF_APOPTOSIS 
                 301 
                 −2.13 
                 1.8E−04 
               
               
                 REGULATION_OF_SIGNAL_TRANSDUCTION 
                 190 
                 −2.12 
                 2.1E−04 
               
               
                 POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 
                 42 
                 −2.11 
                 2.0E−04 
               
               
                 REGULATION_OF_IMMUNE_SYSTEM_PROCESS 
                 54 
                 −2.10 
                 2.0E−04 
               
               
                 POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION 
                 108 
                 −2.10 
                 1.9E−04 
               
               
                 SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION 
                 80 
                 −2.10 
                 2.2E−04 
               
               
                 I_KAPPAB_KINASE_NF_KAPPAB_CASCADE 
                 101 
                 −2.08 
                 2.9E−04 
               
               
                 RESPONSE_TO_CHEMICAL_STIMULUS 
                 252 
                 −2.08 
                 2.8E−04 
               
               
                 CHEMICAL_HOMEOSTASIS 
                 121 
                 −2.07 
                 2.8E−04 
               
               
                 REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_CASCADE 
                 82 
                 −2.06 
                 3.3E−04 
               
               
                 REGULATION_OF_HYDROLASE_ACTIVITY 
                 68 
                 −2.04 
                 4.9E−04 
               
               
                 PROGRAMMED_CELL_DEATH 
                 386 
                 −2.04 
                 5.1E−04 
               
               
                 LEUKOCYTE_DIFFERENTIATION 
                 32 
                 −2.04 
                 4.9E−04 
               
               
                 POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_CASCADE 
                 77 
                 −2.04 
                 4.8E−04 
               
               
                 APOPTOSIS_GO 
                 385 
                 −2.04 
                 4.7E−04 
               
               
                 NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS 
                 161 
                 −2.03 
                 5.7E−04 
               
               
                 POSITIVE_REGULATION_OF_CELL_PROLIFERATION 
                 111 
                 −2.03 
                 5.9E−04 
               
               
                 CATION_HOMEOSTASIS 
                 84 
                 −2.03 
                 5.7E−04 
               
               
                 REGULATION_OF_BIOLOGICAL_QUALITY 
                 334 
                 −2.03 
                 5.6E−04 
               
               
                 RHO_PROTEIN_SIGNAL_TRANSDUCTION 
                 36 
                 −2.03 
                 5.5E−04 
               
               
                 ION_HOMEOSTASIS 
                 98 
                 −2.02 
                 5.6E−04 
               
               
                 CELL_PROLIFERATION_GO_0008283 
                 427 
                 −2.01 
                 5.5E−04 
               
               
                 POSITIVE_REGULATION_OF_BIOLOGICAL_PROCESS 
                 599 
                 −2.01 
                 7.4E−04 
               
               
                 JAK_STAT_CASCADE 
                 27 
                 −2.01 
                 7.5E−04 
               
               
                 ADAPTIVE_IMMUNE_RESPONSE 
                 21 
                 −2.00 
                 7.5E−04 
               
               
                 POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY 
                 44 
                 −2.00 
                 7.6E−04 
               
               
                 CYTOKINE_PRODUCTION 
                 59 
                 −2.00 
                 7.5E−04 
               
               
                 REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS 
                 24 
                 −1.99 
                 8.5E−04 
               
               
                 ADAPTIVE_IMMUNE_RESPONSE_GO_0002460 
                 20 
                 −1.99 
                 8.5E−04 
               
               
                 REGULATION_OF_LYMPHOCYTE_ACTIVATION 
                 29 
                 −1.99 
                 8.8E−04 
               
               
                 POSITIVE_REGULATION_OF_CELLULAR_PROCESS 
                 563 
                 −1.99 
                 8.9E−04 
               
               
                 NEGATIVE_REGULATION_OF_APOPTOSIS 
                 128 
                 −1.98 
                 9.0E−04 
               
               
                 CELLULAR_CATION_HOMEOSTASIS 
                 81 
                 −1.97 
                 0.001 
               
               
                 NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH 
                 129 
                 −1.97 
                 0.001 
               
               
                 HOMEOSTASIS_OF_NUMBER_OF_CELLS 
                 20 
                 −1.96 
                 0.001 
               
               
                 LYMPHOCYTE_DIFFERENTIATION 
                 22 
                 −1.96 
                 0.001 
               
               
                 REGULATION_OF_IMMUNE_RESPONSE 
                 28 
                 −1.96 
                 0.001 
               
               
                 POSITIVE_REGULATION_OF_JNK_ACTIVITY 
                 18 
                 −1.95 
                 0.001 
               
               
                 POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS 
                 34 
                 −1.94 
                 0.001 
               
               
                 CYTOKINE_AND_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY 
                 17 
                 −1.94 
                 0.002 
               
               
                 REGULATION_OF_CELL_ADHESION 
                 27 
                 −1.93 
                 0.002 
               
               
                 CELL_DEVELOPMENT 
                 503 
                 −1.93 
                 0.002 
               
               
                 PEPTIDYL_TYROSINE_MODIFICATION 
                 23 
                 −1.93 
                 0.002 
               
               
                 HUMORAL_IMMUNE_RESPONSE 
                 29 
                 −1.93 
                 0.002 
               
               
                 POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS 
                 56 
                 −1.93 
                 0.002 
               
               
                 CELL_SURFACE_RECEPTOR_LINKED_SIGNAL_TRANSDUCTION_GO_0007166 
                 477 
                 −1.92 
                 0.002 
               
               
                 PEPTIDYL_TYROSINE_PHOSPHORYLATION 
                 21 
                 −1.92 
                 0.002 
               
               
                 REGULATION_OF_MOLECULAR_FUNCTION 
                 278 
                 −1.92 
                 0.002 
               
               
                 REGULATION_OF_CATALYTIC_ACTIVITY 
                 235 
                 −1.92 
                 0.002 
               
               
                 CYTOKINE_METABOLIC_PROCESS 
                 33 
                 −1.92 
                 0.002 
               
               
                 MYELOID_CELL_DIFFERENTIATION 
                 33 
                 −1.91 
                 0.002 
               
               
                 APOPTOTIC_PROGRAM 
                 52 
                 −1.91 
                 0.002 
               
               
                 POSITIVE_REGULATION_OF_CASPASE_ACTIVITY 
                 25 
                 −1.91 
                 0.002 
               
               
                 ANTI_APOPTOSIS 
                 103 
                 −1.91 
                 0.002 
               
               
                 POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS 
                 60 
                 −1.90 
                 0.002 
               
               
                 POSITIVE_REGULATION_OF_IMMUNE_RESPONSE 
                 25 
                 −1.89 
                 0.002 
               
               
                 MEMBRANE_ORGANIZATION_AND_BIOGENESIS 
                 126 
                 −1.89 
                 0.002 
               
               
                 REGULATION_OF_CELL_PROLIFERATION 
                 252 
                 −1.89 
                 0.002 
               
               
                 POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_METABOLIC_PROCESS 
                 58 
                 −1.89 
                 0.002 
               
               
                 CYTOKINE_BIOSYNTHETIC_PROCESS 
                 32 
                 −1.88 
                 0.003 
               
               
                 RESPONSE_TO_BACTERIUM 
                 21 
                 −1.88 
                 0.003 
               
               
                 REGULATION_OF_CELL_MORPHOGENESIS 
                 15 
                 −1.88 
                 0.003 
               
               
                 PROTEIN_AMINO_ACID_PHOSPHORYLATION 
                 246 
                 −1.86 
                 0.003 
               
               
                 POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY 
                 137 
                 −1.86 
                 0.003 
               
               
                 ACTIVATION_OF_JNK_ACTIVITY 
                 16 
                 −1.85 
                 0.004 
               
               
                 POSITIVE_REGULATION_OF_LYMPHOCYTE_ACTIVATION 
                 20 
                 −1.85 
                 0.004 
               
               
                 LIPID_CATABOLIC_PROCESS 
                 28 
                 −1.85 
                 0.004 
               
               
                 PROTEOLYSIS 
                 168 
                 −1.85 
                 0.004 
               
               
                 REGULATION_OF_RESPONSE_TO_STIMULUS 
                 42 
                 −1.85 
                 0.004 
               
               
                 CELLULAR_LIPID_CATABOLIC_PROCESS 
                 27 
                 −1.85 
                 0.004 
               
               
                 RESPONSE_TO_STRESS 
                 432 
                 −1.84 
                 0.004 
               
               
                 MITOTIC_CELL_CYCLE 
                 140 
                 −1.84 
                 0.004 
               
               
                 CELLULAR_HOMEOSTASIS 
                 112 
                 −1.83 
                 0.005 
               
               
                 BLOOD_COAGULATION 
                 34 
                 −1.82 
                 0.006 
               
               
                 REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS 
                 30 
                 −1.81 
                 0.006 
               
               
                 B_CELL_ACTIVATION 
                 17 
                 −1.81 
                 0.006 
               
               
                 PHOSPHORYLATION 
                 273 
                 −1.81 
                 0.006 
               
               
                 RECEPTOR_MEDIATED_ENDOCYTOSIS 
                 32 
                 −1.80 
                 0.006 
               
               
                 COAGULATION 
                 35 
                 −1.80 
                 0.007 
               
               
                 CARBOXYLIC_ACID_METABOLIC_PROCESS 
                 148 
                 −1.80 
                 0.006 
               
               
                 T_CELL_PROLIFERATION 
                 15 
                 −1.80 
                 0.006 
               
               
                 ORGANIC_ACID_METABOLIC_PROCESS 
                 150 
                 −1.80 
                 0.006 
               
               
                 REGULATION_OF_T_CELL_ACTIVATION 
                 23 
                 −1.80 
                 0.006 
               
               
                 CASPASE_ACTIVATION 
                 21 
                 −1.80 
                 0.007 
               
               
                 VIRAL_REPRODUCTIVE_PROCESS 
                 32 
                 −1.79 
                 0.007 
               
               
                 REGULATION_OF_KINASE_ACTIVITY 
                 136 
                 −1.79 
                 0.007 
               
               
                 REGULATION_OF_TRANSFERASE_ACTIVITY 
                 139 
                 −1.79 
                 0.007 
               
               
                 M_PHASE_OF_MITOTIC_CELL_CYCLE 
                 76 
                 −1.79 
                 0.007 
               
               
                 CYTOKINESIS 
                 15 
                 −1.79 
                 0.007 
               
               
                 ACTIN_CYTOSKELETON_ORGANIZATION_AND_BIOGENESIS 
                 96 
                 −1.78 
                 0.007 
               
               
                 MITOSIS 
                 74 
                 −1.78 
                 0.007 
               
               
                 REGULATION_OF_PROTEIN_KINASE_ACTIVITY 
                 134 
                 −1.78 
                 0.007 
               
               
                 POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY 
                 72 
                 −1.78 
                 0.008 
               
               
                 POSITIVE_REGULATION_OF_TRANSLATION 
                 27 
                 −1.77 
                 0.008 
               
               
                 ACTIVATION_OF_MAPK_ACTIVITY 
                 34 
                 −1.77 
                 0.008 
               
               
                 PROTEIN_AMINO_ACID_DEPHOSPHORYLATION 
                 55 
                 −1.77 
                 0.008 
               
               
                 PROTEIN_COMPLEX_ASSEMBLY 
                 152 
                 −1.77 
                 0.008 
               
               
                 NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS 
                 22 
                 −1.77 
                 0.008 
               
               
                 PIGMENT_BIOSYNTHETIC_PROCESS 
                 16 
                 −1.77 
                 0.008 
               
               
                 REGULATION_OF_JNK_ACTIVITY 
                 20 
                 −1.76 
                 0.009 
               
               
                 DEPHOSPHORYLATION 
                 62 
                 −1.76 
                 0.009 
               
               
                 IMMUNE_EFFECTOR_PROCESS 
                 30 
                 −1.76 
                 0.009 
               
               
                 ACTIN_FILAMENT_BASED_PROCESS 
                 104 
                 −1.76 
                 0.009 
               
               
                 G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE 
                 24 
                 −1.75 
                 0.009 
               
               
                 WOUND_HEALING 
                 41 
                 −1.75 
                 0.009 
               
               
                 REGULATION_OF_MITOSIS 
                 35 
                 −1.75 
                 0.009 
               
               
                 POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS 
                 191 
                 −1.75 
                 0.009 
               
               
                 HEMOSTASIS 
                 36 
                 −1.74 
                 0.011 
               
               
                 REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS 
                 116 
                 −1.73 
                 0.011 
               
               
                 POSITIVE_REGULATION_OF_T_CELL_ACTIVATION 
                 18 
                 −1.73 
                 0.011 
               
               
                 INDUCTION_OF_APOPTOSIS_BY_EXTRACELLULAR_SIGNALS 
                 24 
                 −1.73 
                 0.011 
               
               
                 AMINE_METABOLIC_PROCESS 
                 122 
                 −1.73 
                 0.011 
               
               
                 POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY 
                 40 
                 −1.73 
                 0.011 
               
               
                 ACTIVATION_OF_IMMUNE_RESPONSE 
                 17 
                 −1.73 
                 0.012 
               
               
                 VIRAL_REPRODUCTION 
                 36 
                 −1.72 
                 0.012 
               
               
                 LIPID_METABOLIC_PROCESS 
                 261 
                 −1.72 
                 0.012 
               
               
                 CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS 
                 17 
                 −1.71 
                 0.013 
               
               
                 AMINO_ACID_METABOLIC_PROCESS 
                 65 
                 −1.70 
                 0.014 
               
               
                 CELL_CYCLE_PHASE 
                 151 
                 −1.69 
                 0.015 
               
               
                 DEFENSE_RESPONSE_TO_BACTERIUM 
                 15 
                 −1.69 
                 0.016 
               
               
                 VIRAL_INFECTIOUS_CYCLE 
                 28 
                 −1.69 
                 0.016 
               
               
                 NEGATIVE_REGULATION_OF_BIOLOGICAL_PROCESS 
                 586 
                 −1.68 
                 0.016 
               
               
                 CARBOHYDRATE_CATABOLIC_PROCESS 
                 17 
                 −1.68 
                 0.016 
               
               
                 REGULATION_OF_PROTEIN_MODIFICATION_PROCESS 
                 36 
                 −1.68 
                 0.016 
               
               
                 REGULATION_OF_BODY_FLUID_LEVELS 
                 40 
                 −1.68 
                 0.016 
               
               
                 INNATE_IMMUNE_RESPONSE 
                 15 
                 −1.68 
                 0.016 
               
               
                 NITROGEN_COMPOUND_METABOLIC_PROCESS 
                 135 
                 −1.68 
                 0.016 
               
               
                 MAPKKK_CASCADE_GO_0000165 
                 90 
                 −1.68 
                 0.016 
               
               
                 ORGAN_DEVELOPMENT 
                 437 
                 −1.68 
                 0.017 
               
               
                 VASCULATURE_DEVELOPMENT 
                 41 
                 −1.68 
                 0.017 
               
               
                 ORGAN_MORPHOGENESIS 
                 105 
                 −1.68 
                 0.017 
               
               
                 PIGMENT_METABOLIC_PROCESS 
                 17 
                 −1.67 
                 0.017 
               
               
                 MITOTIC_CELL_CYCLE_CHECKPOINT 
                 20 
                 −1.67 
                 0.017 
               
               
                 CELL_CYCLE_PROCESS 
                 174 
                 −1.67 
                 0.018 
               
               
                 REGULATION_OF_PROTEIN_AMINO_ACID_PHOSPHORYLATION 
                 22 
                 −1.66 
                 0.019 
               
               
                 ACTIN_FILAMENT_ORGANIZATION 
                 22 
                 −1.66 
                 0.019 
               
               
                 REGULATION_OF_MAP_KINASE_ACTIVITY 
                 58 
                 −1.66 
                 0.019 
               
               
                 AMINE_TRANSPORT 
                 31 
                 −1.65 
                 0.020 
               
               
                 POST_TRANSLATIONAL_PROTEIN_MODIFICATION 
                 420 
                 −1.65 
                 0.021 
               
               
                 ANGIOGENESIS 
                 34 
                 −1.65 
                 0.021 
               
               
                 CELLULAR_CATABOLIC_PROCESS 
                 181 
                 −1.65 
                 0.021 
               
               
                 CELLULAR_PROTEIN_COMPLEX_ASSEMBLY 
                 31 
                 −1.64 
                 0.022 
               
               
                 NEGATIVE_REGULATION_OF_CELLULAR_PROCESS 
                 569 
                 −1.64 
                 0.022 
               
               
                 STEROID_METABOLIC_PROCESS 
                 50 
                 −1.64 
                 0.022 
               
               
                 RESPONSE_TO_DRUG 
                 20 
                 −1.64 
                 0.023 
               
               
                 CELLULAR_LIPID_METABOLIC_PROCESS 
                 205 
                 −1.64 
                 0.023 
               
               
                 REGULATION_OF_PROTEIN_METABOLIC_PROCESS 
                 150 
                 −1.64 
                 0.023 
               
               
                 INTERACTION_WITH_HOST 
                 16 
                 −1.63 
                 0.023 
               
               
                 POSITIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS 
                 21 
                 −1.63 
                 0.024 
               
               
                 CATABOLIC_PROCESS 
                 191 
                 −1.63 
                 0.024 
               
               
                 HETEROCYCLE_METABOLIC_PROCESS 
                 26 
                 −1.62 
                 0.025 
               
               
                 CYTOSKELETON_ORGANIZATION_AND_BIOGENESIS 
                 189 
                 −1.62 
                 0.026 
               
               
                 G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY 
                 227 
                 −1.61 
                 0.027 
               
               
                 REGULATION_OF_CELL_MIGRATION 
                 24 
                 −1.61 
                 0.027 
               
               
                 ESTABLISHMENT_OF_ORGANELLE_LOCALIZATION 
                 16 
                 −1.61 
                 0.027 
               
               
                 MONOCARBOXYLIC_ACID_METABOLIC_PROCESS 
                 71 
                 −1.61 
                 0.027 
               
               
                 CELL_DIVISION 
                 17 
                 −1.61 
                 0.027 
               
               
                 VIRAL_GENOME_REPLICATION 
                 17 
                 −1.61 
                 0.027 
               
               
                 NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY 
                 58 
                 −1.61 
                 0.027 
               
               
                 REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION 
                 18 
                 −1.60 
                 0.029 
               
               
                 REGULATION_OF_CELL_CYCLE 
                 163 
                 −1.59 
                 0.031 
               
               
                 POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS 
                 22 
                 −1.59 
                 0.032 
               
               
                 CELL_CYCLE_GO_0007049 
                 284 
                 −1.59 
                 0.032 
               
               
                 REGULATION_OF_CELLULAR_PROTEIN_METABOLIC_PROCESS 
                 141 
                 −1.58 
                 0.033 
               
               
                 REGULATION_OF_PHOSPHORYLATION 
                 36 
                 −1.58 
                 0.033 
               
               
                 M_PHASE 
                 98 
                 −1.58 
                 0.033 
               
               
                 CARBOHYDRATE_METABOLIC_PROCESS 
                 148 
                 −1.58 
                 0.035 
               
               
                 REGULATION_OF_DNA_BINDING 
                 40 
                 −1.57 
                 0.037 
               
               
                 MAINTENANCE_OF_LOCALIZATION 
                 18 
                 −1.56 
                 0.038 
               
               
                 AMINO_ACID_TRANSPORT 
                 22 
                 −1.56 
                 0.040 
               
               
                 PROTEIN_SECRETION 
                 24 
                 −1.55 
                 0.043 
               
               
                 CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS 
                 108 
                 −1.55 
                 0.044 
               
               
                 POSITIVE_REGULATION_OF_CELLULAR_METABOLIC_PROCESS 
                 192 
                 −1.54 
                 0.044 
               
               
                 REGULATION_OF_GTPASE_ACTIVITY 
                 16 
                 −1.54 
                 0.044 
               
               
                 SPHINGOLIPID_METABOLIC_PROCESS 
                 22 
                 −1.54 
                 0.044 
               
               
                 CELL_MIGRATION 
                 79 
                 −1.54 
                 0.044 
               
               
                 ORGANELLE_LOCALIZATION 
                 23 
                 −1.53 
                 0.047 
               
               
                 POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION_AND_BIOGENESIS 
                 30 
                 −1.53 
                 0.047 
               
               
                 CELLULAR_RESPONSE_TO_STIMULUS 
                 16 
                 −1.53 
                 0.049 
               
               
                 TISSUE_DEVELOPMENT 
                 103 
                 −1.53 
                 0.049 
               
               
                 POSITIVE_REGULATION_OF_METABOLIC_PROCESS 
                 198 
                 −1.53 
                 0.049 
               
               
                 MESODERM_DEVELOPMENT 
                 22 
                 −1.52 
                 0.050 
               
               
                 VESICLE_MEDIATED_TRANSPORT 
                 178 
                 −1.52 
                 0.050 
               
               
                 PROTEIN_OLIGOMERIZATION 
                 33 
                 −1.52 
                 0.050 
               
               
                 CELLULAR_MACROMOLECULE_CATABOLIC_PROCESS 
                 93 
                 −1.51 
                 0.052 
               
               
                 COFACTOR_METABOLIC_PROCESS 
                 50 
                 −1.51 
                 0.053 
               
               
                 INTERPHASE 
                 63 
                 −1.51 
                 0.053 
               
               
                 SECONDARY_METABOLIC_PROCESS 
                 22 
                 −1.51 
                 0.053 
               
               
                 REGULATION_OF_CELL_GROWTH 
                 37 
                 −1.51 
                 0.053 
               
               
                 CHROMOSOME_SEGREGATION 
                 29 
                 −1.51 
                 0.054 
               
               
                 NEGATIVE_REGULATION_OF_CELL_PROLIFERATION 
                 132 
                 −1.50 
                 0.056 
               
               
                 MEMBRANE_LIPID_METABOLIC_PROCESS 
                 87 
                 −1.50 
                 0.056 
               
               
                 NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY 
                 31 
                 −1.50 
                 0.057 
               
               
                 PROTEIN_TRANSPORT 
                 147 
                 −1.50 
                 0.056 
               
               
                 PEPTIDYL_AMINO_ACID_MODIFICATION 
                 55 
                 −1.50 
                 0.057 
               
               
                 REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSD N   
                 22 
                 −1.50 
                 0.057 
               
               
                 POSITIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS 
                 18 
                 −1.50 
                 0.057 
               
               
                 SECOND_MESSENGER_MEDIATED_SIGNALING 
                 111 
                 −1.50 
                 0.057 
               
               
                 REGULATION_OF_PROTEIN_SECRETION 
                 16 
                 −1.49 
                 0.059 
               
               
                 MITOCHONDRION_ORGANIZATION_AND_BIOGENESIS 
                 44 
                 −1.49 
                 0.060 
               
               
                 RESPONSE_TO_EXTRACELLULAR_STIMULUS 
                 22 
                 −1.49 
                 0.061 
               
               
                 PROTEIN_IMPORT_INTO_NUCLEUS 
                 44 
                 −1.49 
                 0.061 
               
               
                 PROTEIN_LOCALIZATION 
                 194 
                 −1.48 
                 0.061 
               
               
                 REGULATION_OF_BINDING 
                 51 
                 −1.48 
                 0.062 
               
               
                 POSITIVE_REGULATION_OF_DNA_BINDING 
                 21 
                 −1.48 
                 0.062 
               
               
                 BIOPOLYMER_MODIFICATION 
                 578 
                 −1.48 
                 0.063 
               
               
                 PROTEIN_MODIFICATION_PROCESS 
                 562 
                 −1.48 
                 0.064 
               
               
                 ESTABLISHMENT_OF_CELLULAR_LOCALIZATION 
                 323 
                 −1.47 
                 0.064 
               
               
                 STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_PATHWAY 
                 47 
                 −1.47 
                 0.064 
               
               
                 REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY 
                 18 
                 −1.47 
                 0.065 
               
               
                 NEGATIVE_REGULATION_OF_GROWTH 
                 34 
                 −1.47 
                 0.065 
               
               
                 NUCLEAR_IMPORT 
                 46 
                 −1.47 
                 0.065 
               
               
                 NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION 
                 34 
                 −1.47 
                 0.065 
               
               
                 ESTABLISHMENT_OF_PROTEIN_LOCALIZATION 
                 173 
                 −1.47 
                 0.066 
               
               
                 CELL_CELL_SIGNALING 
                 291 
                 −1.46 
                 0.068 
               
               
                 CARBOXYLIC_ACID_TRANSPORT 
                 36 
                 −1.46 
                 0.068 
               
               
                 FATTY_ACID_METABOLIC_PROCESS 
                 52 
                 −1.46 
                 0.070 
               
               
                 POSITIVE_REGULATION_OF_BINDING 
                 23 
                 −1.46 
                 0.071 
               
               
                 NEURON_DIFFERENTIATION 
                 58 
                 −1.45 
                 0.072 
               
               
                 POSITIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_ACTIVITY 
                 20 
                 −1.45 
                 0.072 
               
               
                 ORGANIC_ACID_TRANSPORT 
                 37 
                 −1.45 
                 0.074 
               
               
                 INTRACELLULAR_TRANSPORT 
                 263 
                 −1.44 
                 0.076 
               
               
                 REGULATION_OF_ANGIOGENESIS 
                 17 
                 −1.44 
                 0.077 
               
               
                 CELL_CYCLE_CHECKPOINT_GO_0000075 
                 42 
                 −1.44 
                 0.079 
               
               
                 RESPONSE_TO_HYPOXIA 
                 23 
                 −1.44 
                 0.080 
               
               
                 CELL_CELL_ADHESION 
                 70 
                 −1.43 
                 0.081 
               
               
                 MACROMOLECULE_LOCALIZATION 
                 216 
                 −1.43 
                 0.082 
               
               
                 NUCLEOTIDE_BIOSYNTHETIC_PROCESS 
                 16 
                 −1.43 
                 0.082 
               
               
                 INTERPHASE_OF_MITOTIC_CELL_CYCLE 
                 57 
                 −1.43 
                 0.083 
               
               
                 G_PROTEIN_SIGNALING_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER 
                 68 
                 −1.42 
                 0.087 
               
               
                 INDUCTION_OF_APOPTOSIS_BY_INTRACELLULAR_SIGNALS 
                 21 
                 −1.42 
                 0.087 
               
               
                 REGULATION_OF_TRANSCRIPTION_FACTOR_ACTIVITY 
                 34 
                 −1.42 
                 0.087 
               
               
                 REGULATION_OF_INTRACELLULAR_TRANSPORT 
                 23 
                 −1.42 
                 0.087 
               
               
                 CELLULAR_LOCALIZATION 
                 340 
                 −1.41 
                 0.090 
               
               
                 INTRACELLULAR_PROTEIN_TRANSPORT 
                 136 
                 −1.41 
                 0.090 
               
               
                 AMINO_ACID_CATABOLIC_PROCESS 
                 19 
                 −1.41 
                 0.092 
               
               
                 POSITIVE_REGULATION_OF_PHOSPHORYLATION 
                 16 
                 −1.41 
                 0.093 
               
               
                 NEGATIVE_REGULATION_OF_CELL_CYCLE 
                 73 
                 −1.41 
                 0.093 
               
               
                 ANATOMICAL_STRUCTURE_FORMATION 
                 42 
                 −1.40 
                 0.095 
               
               
                 EPIDERMIS_DEVELOPMENT 
                 48 
                 −1.40 
                 0.095 
               
               
                 ANATOMICAL_STRUCTURE_MORPHOGENESIS 
                 303 
                 −1.40 
                 0.096 
               
               
                 TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY 
                 70 
                 −1.40 
                 0.098 
               
               
                 CELL_CYCLE_ARREST_GO_0007050 
                 52 
                 −1.40 
                 0.098 
               
               
                 GROWTH 
                 60 
                 −1.40 
                 0.098 
               
               
                 ENDOSOME_TRANSPORT 
                 23 
                 −1.39 
                 0.098 
               
               
                 REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION_AND_BIOGENESIS 
                 114 
                 −1.39 
                 0.102 
               
               
                 REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT 
                 20 
                 −1.39 
                 0.102 
               
               
                 ACTIVATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR 
                 16 
                 −1.39 
                 0.103 
               
               
                 JNK_CASCADE 
                 45 
                 −1.38 
                 0.104 
               
               
                 ORGANELLE_ORGANIZATION_AND_BIOGENESIS 
                 431 
                 −1.38 
                 0.104 
               
               
                 POSITIVE_REGULATION_OF_TRANSPORT 
                 18 
                 −1.38 
                 0.105 
               
               
                 AMINE_CATABOLIC_PROCESS 
                 20 
                 −1.38 
                 0.104 
               
               
                 AMINO_ACID_AND_DERIVATIVE_METABOLIC_PROCESS 
                 84 
                 −1.38 
                 0.107 
               
               
                 CELL_PROJECTION_BIOGENESIS 
                 26 
                 −1.38 
                 0.109 
               
               
                 NITROGEN_COMPOUND_CATABOLIC_PROCESS 
                 22 
                 −1.37 
                 0.109 
               
               
                 ALCOHOL_METABOLIC_PROCESS 
                 73 
                 −1.37 
                 0.110 
               
               
                 CELL_MATRIX_ADHESION 
                 33 
                 −1.37 
                 0.109 
               
               
                 MACROMOLECULE_CATABOLIC_PROCESS 
                 120 
                 −1.37 
                 0.109 
               
               
                 MONOVALENT_INORGANIC_CATION_TRANSPORT 
                 67 
                 −1.36 
                 0.119 
               
               
                 ECTODERM_DEVELOPMENT 
                 56 
                 −1.35 
                 0.125 
               
               
                 ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY 
                 119 
                 −1.35 
                 0.125 
               
               
                 GENERATION_OF_NEURONS 
                 64 
                 −1.35 
                 0.125 
               
               
                 PHOSPHOINOSITIDE_BIOSYNTHETIC_PROCESS 
                 24 
                 −1.35 
                 0.127 
               
               
                 RESPONSE_TO_ORGANIC_SUBSTANCE 
                 27 
                 −1.35 
                 0.127 
               
               
                 PROTEIN_AMINO_ACID_N_LINKED_GLYCOSYLATION 
                 27 
                 −1.34 
                 0.129 
               
               
                 MUSCLE_DEVELOPMENT 
                 77 
                 −1.34 
                 0.131 
               
               
                 LIPID_BIOSYNTHETIC_PROCESS 
                 84 
                 −1.34 
                 0.131 
               
               
                 MITOCHONDRIAL_TRANSPORT 
                 20 
                 −1.34 
                 0.133 
               
               
                 ER_NUCLEAR_SIGNALING_PATHWAY 
                 16 
                 −1.34 
                 0.134 
               
               
                 PHOSPHOLIPID_METABOLIC_PROCESS 
                 66 
                 −1.34 
                 0.134 
               
               
                 REGULATION_OF_GROWTH 
                 45 
                 −1.33 
                 0.135 
               
               
                 ANION_TRANSPORT 
                 18 
                 −1.33 
                 0.135 
               
               
                 SISTER_CHROMATID_SEGREGATION 
                 15 
                 −1.33 
                 0.135 
               
               
                 COFACTOR_BIOSYNTHETIC_PROCESS 
                 21 
                 −1.33 
                 0.136 
               
               
                 REGULATION_OF_CELL_DIFFERENTIATION 
                 47 
                 −1.33 
                 0.138 
               
               
                 RHYTHMIC_PROCESS 
                 18 
                 −1.33 
                 0.138 
               
               
                 CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING 
                 70 
                 −1.33 
                 0.139 
               
               
                 REGULATION_OF_GENE_EXPRESSION 
                 595 
                 −1.32 
                 0.140 
               
               
                 BONE_REMODELING 
                 23 
                 −1.32 
                 0.140 
               
               
                 NEUROGENESIS 
                 74 
                 −1.32 
                 0.140 
               
               
                 PROTEIN_TARGETING 
                 101 
                 −1.32 
                 0.141 
               
               
                 RESPONSE_TO_OXIDATIVE_STRESS 
                 39 
                 −1.32 
                 0.143 
               
               
                 CELL_SUBSTRATE_ADHESION 
                 34 
                 −1.32 
                 0.144 
               
               
                 NUCLEOCYTOPLASMIC_TRANSPORT 
                 83 
                 −1.31 
                 0.153 
               
               
                 CELLULAR_BIOSYNTHETIC_PROCESS 
                 281 
                 −1.30 
                 0.157 
               
               
                 REGULATION_OF_TRANSPORT 
                 56 
                 −1.30 
                 0.161 
               
               
                 PROTEIN_IMPORT 
                 57 
                 −1.29 
                 0.166 
               
               
                 NUCLEAR_TRANSPORT 
                 84 
                 −1.29 
                 0.170 
               
               
                 MEMBRANE_FUSION 
                 26 
                 −1.29 
                 0.171 
               
               
                 REPRODUCTIVE_PROCESS 
                 102 
                 −1.28 
                 0.173 
               
               
                 NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION_AND_BIOGENESIS 
                 26 
                 −1.28 
                 0.173 
               
               
                 REGULATION_OF_NUCLEOBASE_NUCLEOSIDE_NUCLEOTIDE_AND —   
                 541 
                 −1.27 
                 0.182 
               
               
                 NUCLEIC_ACID_METABOLIC_PROCESS 
               
               
                 REGULATION_OF_TRANSCRIPTION 
                 503 
                 −1.27 
                 0.184 
               
               
                 NUCLEAR_ORGANIZATION_AND_BIOGENESIS 
                 25 
                 −1.27 
                 0.183 
               
               
                 GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS 
                 43 
                 −1.27 
                 0.183 
               
               
                 MICROTUBULE_BASED_PROCESS 
                 77 
                 −1.27 
                 0.185 
               
               
                 NEURON_DEVELOPMENT 
                 50 
                 −1.27 
                 0.185 
               
               
                 CELL_STRUCTURE_DISASSEMBLY_DURING_APOPTOSIS 
                 16 
                 −1.26 
                 0.191 
               
               
                 TISSUE_REMODELING 
                 24 
                 −1.26 
                 0.196 
               
               
                 SKELETAL_DEVELOPMENT 
                 78 
                 −1.26 
                 0.197 
               
               
                 CELLULAR_COMPONENT_ASSEMBLY 
                 269 
                 −1.26 
                 0.197 
               
               
                 NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_METABOLIC_PROCESS 
                 42 
                 −1.25 
                 0.203 
               
               
                 REGULATION_OF_TRANSLATION 
                 80 
                 −1.25 
                 0.203 
               
               
                 VITAMIN_METABOLIC_PROCESS 
                 15 
                 −1.25 
                 0.205 
               
               
                 NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS 
                 44 
                 −1.24 
                 0.208 
               
               
                 MACROMOLECULAR_COMPLEX_ASSEMBLY 
                 256 
                 −1.24 
                 0.209 
               
               
                 AMINO_SUGAR_METABOLIC_PROCESS 
                 18 
                 −1.24 
                 0.209 
               
               
                 NUCLEOTIDE_METABOLIC_PROCESS 
                 35 
                 −1.23 
                 0.218 
               
               
                 BIOSYNTHETIC_PROCESS 
                 417 
                 −1.23 
                 0.218 
               
               
                 RESPONSE_TO_UV 
                 22 
                 −1.23 
                 0.218 
               
               
                 ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY 
                 24 
                 −1.23 
                 0.222 
               
               
                 REGULATION_OF_MYELOID_CELL_DIFFERENTIATION 
                 17 
                 −1.23 
                 0.222 
               
               
                 ACTIN_POLYMERIZATION_AND_OR_DEPOLYMERIZATION 
                 20 
                 −1.22 
                 0.227 
               
               
                 TRANSCRIPTION_DNA_DEPENDENT 
                 564 
                 −1.22 
                 0.229 
               
               
                 TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER 
                 410 
                 −1.22 
                 0.229 
               
               
                 REGULATION_OF_TRANSCRIPTION_DNA_DEPENDENT 
                 411 
                 −1.22 
                 0.236 
               
               
                 RNA_CATABOLIC_PROCESS 
                 20 
                 −1.21 
                 0.241 
               
               
                 TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY 
                 31 
                 −1.21 
                 0.242 
               
               
                 RNA_BIOSYNTHETIC_PROCESS 
                 566 
                 −1.21 
                 0.241 
               
               
                 GLYCOPROTEIN_METABOLIC_PROCESS 
                 84 
                 −1.21 
                 0.241 
               
               
                 FEMALE_PREGNANCY 
                 26 
                 −1.21 
                 0.246 
               
               
                 REGULATION_OF_RNA_METABOLIC_PROCESS 
                 414 
                 −1.20 
                 0.250 
               
               
                 SECRETION_BY_CELL 
                 99 
                 −1.20 
                 0.249 
               
               
                 PHOSPHOINOSITIDE_METABOLIC_PROCESS 
                 30 
                 −1.20 
                 0.250 
               
               
                 REGULATION_OF_CYTOSKELETON_ORGANIZATION_AND_BIOGENESIS 
                 29 
                 −1.20 
                 0.253 
               
               
                 NEGATIVE_REGULATION_OF_METABOLIC_PROCESS 
                 238 
                 −1.20 
                 0.254 
               
               
                 NEGATIVE_REGULATION_OF_CELLULAR_METABOLIC_PROCESS 
                 237 
                 −1.19 
                 0.257 
               
               
                 REGULATION_OF_MITOTIC_CELL_CYCLE 
                 19 
                 −1.18 
                 0.270 
               
               
                 STEROID_BIOSYNTHETIC_PROCESS 
                 17 
                 −1.18 
                 0.282 
               
               
                 PROTEOGLYCAN_METABOLIC_PROCESS 
                 16 
                 −1.18 
                 0.282 
               
               
                 NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER 
                 80 
                 −1.17 
                 0.282 
               
               
                 POSITIVE_REGULATION_OF_TRANSCRIPTION 
                 127 
                 −1.17 
                 0.283 
               
               
                 NEGATIVE_REGULATION_OF_TRANSCRIPTION_DNA_DEPENDENT 
                 121 
                 −1.16 
                 0.305 
               
               
                 RESPONSE_TO_NUTRIENT_LEVELS 
                 19 
                 −1.15 
                 0.313 
               
               
                 NEGATIVE_REGULATION_OF_TRANSCRIPTION 
                 177 
                 −1.15 
                 0.315 
               
               
                 POSITIVE_REGULATION_OF_NUCLEOBASE_NUCLEOSIDE_NUCLEOTIDE_AND_NUCLEIC —   
                 133 
                 −1.15 
                 0.318 
               
               
                 ACID_METABOLIC_PROCESS 
               
               
                 NEGATIVE_REGULATION_OF_RNA_METABOLIC_PROCESS 
                 121 
                 −1.15 
                 0.321 
               
               
                 GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PROCESS 
                 30 
                 −1.14 
                 0.324 
               
               
                 ION_TRANSPORT 
                 129 
                 −1.14 
                 0.326 
               
               
                 DETECTION_OF_STIMULUS 
                 26 
                 −1.14 
                 0.326 
               
               
                 PROTEIN_PROCESSING 
                 43 
                 −1.14 
                 0.326 
               
               
                 REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER 
                 261 
                 −1.14 
                 0.328 
               
               
                 BIOPOLYMER_CATABOLIC_PROCESS 
                 107 
                 −1.14 
                 0.330 
               
               
                 NEGATIVE_REGULATION_OF_NUCLEOBASE_NUCLEOSIDE_NUCLEOTIDE_AND_NUCLEIC —   
                 193 
                 −1.13 
                 0.339 
               
               
                 ACID_METABOLIC_PROCESS 
               
               
                 COENZYME_METABOLIC_PROCESS 
                 35 
                 −1.13 
                 0.342 
               
               
                 SULFUR_METABOLIC_PROCESS 
                 34 
                 −1.13 
                 0.346 
               
               
                 EXOCYTOSIS 
                 21 
                 −1.13 
                 0.347 
               
               
                 NEGATIVE_REGULATION_OF_TRANSPORT 
                 18 
                 −1.12 
                 0.356 
               
               
                 PROTEIN_AUTOPROCESSING 
                 29 
                 −1.12 
                 0.356 
               
               
                 INSULIN_RECEPTOR_SIGNALING_PATHWAY 
                 19 
                 −1.12 
                 0.358 
               
               
                 RESPONSE_TO_ABIOTIC_STIMULUS 
                 73 
                 −1.12 
                 0.360 
               
               
                 PROTEIN_AMINO_ACID_AUTOPHOSPHORYLATION 
                 29 
                 −1.11 
                 0.362 
               
               
                 REGULATION_OF_GENE_EXPRESSION_EPIGENETIC 
                 28 
                 −1.11 
                 0.368 
               
               
                 PHOSPHOLIPID_BIOSYNTHETIC_PROCESS 
                 38 
                 −1.11 
                 0.369 
               
               
                 NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY 
                 16 
                 −1.11 
                 0.372 
               
               
                 REGUL N _OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY 
                 39 
                 −1.10 
                 0.392 
               
               
                 NITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS 
                 23 
                 −1.09 
                 0.407 
               
               
                 RESPONSE_TO_HORMONE_STIMULUS 
                 27 
                 −1.09 
                 0.407 
               
               
                 CALCIUM_MEDIATED_SIGNALING 
                 15 
                 −1.08 
                 0.424 
               
               
                 REGULATION_OF_SECRETION 
                 30 
                 −1.07 
                 0.433 
               
               
                 TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY 
                 41 
                 −1.06 
                 0.450 
               
               
                 AROMATIC_COMPOUND_METABOLIC_PROCESS 
                 25 
                 −1.06 
                 0.454 
               
               
                 NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION 
                 21 
                 −1.06 
                 0.454 
               
               
                 DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION 
                 31 
                 −1.06 
                 0.458 
               
               
                 GLUCOSE_METABOLIC_PROCESS 
                 23 
                 −1.06 
                 0.457 
               
               
                 REGULATION_OF_CYTOKINE_PRODUCTION 
                 20 
                 −1.06 
                 0.456 
               
               
                 PROTEIN_HOMOOLIGOMERIZATION 
                 20 
                 −1.05 
                 0.462 
               
               
                 REPRODUCTION 
                 172 
                 −1.05 
                 0.464 
               
               
                 NUCLEOBASE_NUCLEOSIDE_AND_NUCLEOTIDE_METABOLIC_PROCESS 
                 45 
                 −1.05 
                 0.463 
               
               
                 PHOSPHOINOSITIDE_MEDIATED_SIGNALING 
                 36 
                 −1.04 
                 0.476 
               
               
                 ESTABLISHMENT_AND_OR_MAINTENANCE_OF_CELL_POLARITY 
                 18 
                 −1.04 
                 0.484 
               
               
                 APOPTOTIC_NUCLEAR_CHANGES 
                 17 
                 −1.03 
                 0.496 
               
               
                 CARBOHYDRATE_TRANSPORT 
                 16 
                 −1.02 
                 0.509 
               
               
                 EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY 
                 18 
                 −1.02 
                 0.511 
               
               
                 SYSTEM_PROCESS 
                 393 
                 −1.02 
                 0.512 
               
               
                 CELLULAR_COMPONENT_DISASSEMBLY 
                 30 
                 −1.02 
                 0.524 
               
               
                 MICROTUBULE_CYTOSKELETON_ORGANIZ N _AND_BIOGENESIS 
                 33 
                 −1.01 
                 0.528 
               
               
                 PROTEIN_POLYMERIZATION 
                 16 
                 −1.01 
                 0.534 
               
               
                 MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS 
                 44 
                 −1.01 
                 0.533 
               
               
                 CATION_TRANSPORT 
                 107 
                 −1.01 
                 0.532 
               
               
                 SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS 
                 15 
                 −1.00 
                 0.542 
               
               
                 G_PROTEIN_SIGNALING_COUPLED_TO_CAMP_NUCLEOTIDE_SECOND_MESSENGER 
                 44 
                 −1.00 
                 0.556 
               
               
                 NEURITE_DEVELOPMENT 
                 43 
                 −1.00 
                 0.555 
               
               
                 TRANSCRIPT N _INITIATION_FROM_RNA_POLYMERASEII_PROMOTER 
                 28 
                 −0.99 
                 0.555 
               
               
                 NERVOUS_SYSTEM_DEVELOPMENT 
                 291 
                 −0.99 
                 0.556 
               
               
                 POSITIVE_REGULATION_OF_TRANSCRIPTION_DNA_DEPENDENT 
                 106 
                 −0.99 
                 0.555 
               
               
                 INTRACELLULAR_RECEPTOR_MEDIATED_SIGNALING_PATHWAY 
                 20 
                 −0.99 
                 0.554 
               
               
                 CAMP_MEDIATED_SIGNALING 
                 45 
                 −0.99 
                 0.555 
               
               
                 RESPONSE_TO_RADIATION 
                 47 
                 −0.99 
                 0.556 
               
               
                 REGULATION_OF_MAPKKK_CASCADE 
                 17 
                 −0.99 
                 0.557 
               
               
                 POSITIVE_REGULATION_OF_RNA_METABOLIC_PROCESS 
                 107 
                 −0.99 
                 0.560 
               
               
                 NEGATIVE_REGULATION_OF_BINDING 
                 16 
                 −0.98 
                 0.574 
               
               
                 AXONOGENESIS 
                 36 
                 −0.98 
                 0.579 
               
               
                 STRIATED_MUSCLE_DEVELOPMENT 
                 31 
                 −0.98 
                 0.578 
               
               
                 NEGATIVE_REGULATION_OF_DNA_BINDING 
                 15 
                 −0.98 
                 0.580 
               
               
                 SECRETION 
                 143 
                 −0.97 
                 0.583 
               
               
                 TRNA_METABOLIC_PROCESS 
                 19 
                 −0.97 
                 0.596 
               
               
                 NEGATIVE_REGULATION_OF_TRANSLATION 
                 20 
                 −0.96 
                 0.598 
               
               
                 DNA_INTEGRITY_CHECKPOINT 
                 21 
                 −0.95 
                 0.626 
               
               
                 REGULATION_OF_ORGANELLE_ORGANIZATION_AND_BIOGENESIS 
                 38 
                 −0.95 
                 0.635 
               
               
                 CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT 
                 23 
                 −0.95 
                 0.633 
               
               
                 G_PROTEIN_SIGNALING_COUPLED_TO_IP3_SECOND_MESSENGER_PHOSPHOLIPASE_C_ACTIVATING 
                 33 
                 −0.94 
                 0.643 
               
               
                 HEART_DEVELOPMENT 
                 29 
                 −0.93 
                 0.653 
               
               
                 POTASSIUM_ION_TRANSPORT 
                 38 
                 −0.93 
                 0.660 
               
               
                 SYNAPTOGENESIS 
                 15 
                 −0.93 
                 0.666 
               
               
                 RESPONSE_TO_LIGHT_STIMULUS 
                 34 
                 −0.92 
                 0.673 
               
               
                 DNA_CATABOLIC_PROCESS 
                 20 
                 −0.91 
                 0.685 
               
               
                 NEGATIVE_REGULATION_OF_CELLULAR_BIOSYNTHETIC_PROCESS 
                 26 
                 −0.91 
                 0.685 
               
               
                 TRANSLATION 
                 159 
                 −0.91 
                 0.686 
               
               
                 SENSORY_PERCEPTION 
                 132 
                 −0.91 
                 0.691 
               
               
                 EXTRACELLULAR_STRUCTURE_ORGANIZATION_AND_BIOGENESIS 
                 26 
                 −0.90 
                 0.700 
               
               
                 SECRETORY_PATHWAY 
                 75 
                 −0.90 
                 0.714 
               
               
                 CELLULAR_PROTEIN_CATABOLIC_PROCESS 
                 56 
                 −0.89 
                 0.717 
               
               
                 NEGATIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS 
                 27 
                 −0.89 
                 0.724 
               
               
                 POLYSACCHARIDE_METABOLIC_PROCESS 
                 16 
                 −0.89 
                 0.727 
               
               
                 OXYGEN_AND_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS 
                 19 
                 −0.88 
                 0.728 
               
               
                 REGULATION_OF_DNA_METABOLIC_PROCESS 
                 34 
                 −0.88 
                 0.736 
               
               
                 ONE_CARBON_COMPOUND_METABOLIC_PROCESS 
                 25 
                 −0.87 
                 0.748 
               
               
                 REGULATION_OF_NEUROTRANSMITTER_LEVELS 
                 17 
                 −0.87 
                 0.750 
               
               
                 MACROMOLECULE_BIOSYNTHETIC_PROCESS 
                 289 
                 −0.87 
                 0.751 
               
               
                 DNA_DAMAGE_CHECKPOINT 
                 18 
                 −0.86 
                 0.764 
               
               
                 PROTEIN_CATABOLIC_PROCESS 
                 65 
                 −0.86 
                 0.772 
               
               
                 CELLULAR_MORPHOGENESIS_DURING_DIFFERENTIATION 
                 42 
                 −0.85 
                 0.772 
               
               
                 TRANSCRIPTION_INITIATION 
                 34 
                 −0.85 
                 0.779 
               
               
                 NEURON_APOPTOSIS 
                 15 
                 −0.85 
                 0.780 
               
               
                 NEUROLOGICAL_SYSTEM_PROCESS 
                 261 
                 −0.85 
                 0.780 
               
               
                 ELECTRON_TRANSPORT_GO_0006118 
                 47 
                 −0.85 
                 0.779 
               
               
                 STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY 
                 19 
                 −0.83 
                 0.810 
               
               
                 DNA_METABOLIC_PROCESS 
                 227 
                 −0.82 
                 0.816 
               
               
                 SKELETAL_MUSCLE_DEVELOPMENT 
                 23 
                 −0.81 
                 0.827 
               
               
                 GOLGI_VESICLE_TRANSPORT 
                 46 
                 −0.81 
                 0.831 
               
               
                 SYNAPTIC_TRANSMISSION 
                 115 
                 −0.81 
                 0.835 
               
               
                 LIPOPROTEIN_METABOLIC_PROCESS 
                 31 
                 −0.80 
                 0.844 
               
               
                 NUCLEAR_EXPORT 
                 34 
                 −0.80 
                 0.845 
               
               
                 METAL_ION_TRANSPORT 
                 85 
                 −0.79 
                 0.854 
               
               
                 GLYCOPROTEIN_BIOSYNTHETIC_PROCESS 
                 68 
                 −0.79 
                 0.852 
               
               
                 SYNAPSE_ORGANIZATION_AND_BIOGENESIS 
                 19 
                 −0.79 
                 0.852 
               
               
                 MORPHOGENESIS_OF_AN_EPITHELIUM 
                 15 
                 −0.78 
                 0.858 
               
               
                 TRANSMISSION_OF_NERVE_IMPULSE 
                 129 
                 −0.78 
                 0.867 
               
               
                 PROTEIN_UBIQUITINATION 
                 37 
                 −0.75 
                 0.899 
               
               
                 PROTEIN_FOLDING 
                 50 
                 −0.74 
                 0.904 
               
               
                 DIGESTION 
                 22 
                 −0.74 
                 0.906 
               
               
                 BRAIN_DEVELOPMENT 
                 41 
                 −0.72 
                 0.930 
               
               
                 SODIUM_ION_TRANSPORT 
                 16 
                 −0.69 
                 0.952 
               
               
                 DNA_PACKAGING 
                 30 
                 −0.68 
                 0.954 
               
               
                 ADENYLATE_CYCLASE_ACTIVATION 
                 16 
                 −0.68 
                 0.952 
               
               
                 CARBOHYDRATE_BIOSYNTHETIC_PROCESS 
                 43 
                 −0.66 
                 0.961 
               
               
                 G_PROTEIN_SIGNALING_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY 
                 19 
                 −0.65 
                 0.967 
               
               
                 UBIQUITIN_CYCLE 
                 44 
                 −0.64 
                 0.970 
               
               
                 PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION 
                 40 
                 −0.64 
                 0.970 
               
               
                 RESPONSE_TO_ENDOGENOUS_STIMULUS 
                 176 
                 −0.64 
                 0.968 
               
               
                 ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT 
                 18 
                 −0.62 
                 0.974 
               
               
                 GENERAT N _OF_A_SIGNAL_INVOLVED_IN_CELL_CELL_SIGNALING 
                 21 
                 −0.59 
                 0.982 
               
               
                 MICROTUBULE_BASED_MOVEMENT 
                 15 
                 −0.43 
                 0.999 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                   
                 TABLE 5 
               
               
                   
                   
               
             
            
               
                   
                 Signal transduction 
               
               
                   
                 CYTOKINE AND 
               
               
                   
                 CHEMOKINE MEDIATED 
               
               
                   
                 SIGNALING PATHWAY 
               
               
                   
                 CELL SURFACE RECEPTOR 
               
               
                   
                 LINKED SIGNAL 
               
               
                   
                 TRANSDUCTION GO0007166 
               
               
                   
                 SMALL GTPASE MEDIATED 
               
               
                   
                 SIGNAL TRANSDUCTION 
               
               
                   
                 RAS PROTEIN SIGNAL 
               
               
                   
                 TRANSDUCTION 
               
               
                   
                 RHO PROTEIN SIGNAL 
               
               
                   
                 TRANSDUCTION 
               
               
                   
                 PROTEIN KINASE CASCADE 
               
               
                   
                 INTRACELLULAR 
               
               
                   
                 SIGNALING CASCADE 
               
               
                   
                 REGULATION OF SIGNAL 
               
               
                   
                 TRANSDUCTION 
               
               
                   
                 POSITIVE REGULATION OF 
               
               
                   
                 SIGNAL TRANSDUCTION 
               
               
                   
                 I KAPPAB KINASE NF 
               
               
                   
                 KAPPAB CASCADE 
               
               
                   
                 REGULATION OF I KAPPAB 
               
               
                   
                 KINASE NF KAPPAB 
               
               
                   
                 CASCADE 
               
               
                   
                 POSITIVE REGULATION OF I 
               
               
                   
                 KAPPAB KINASE NF KAPPAB 
               
               
                   
                 CASCADE 
               
               
                   
                 JAK STAT CASCADE 
               
               
                   
                 REGULATION OF PROTEIN 
               
               
                   
                 KINASE ACTIVITY 
               
               
                   
                 REGULATION OF KINASE 
               
               
                   
                 ACTIVITY 
               
               
                   
                 REGULATION OF 
               
               
                   
                 TRANSFERASE ACTIVITY 
               
               
                   
                 POSITIVE REGULATION OF 
               
               
                   
                 TRANSFERASE ACTIVITY 
               
               
                   
                 ACTIVATION OF MAPK 
               
               
                   
                 ACTIVITY 
               
               
                   
                 REGULATION OF 
               
               
                   
                 CATALYTIC ACTIVITY 
               
               
                   
                 POSITIVE REGULATION OF 
               
               
                   
                 CATALYTIC ACTIVITY 
               
               
                   
                 REGULATION OF JNK 
               
               
                   
                 ACTIVITY 
               
               
                   
                 POSITIVE REGULATION OF 
               
               
                   
                 JNK ACTIVITY 
               
               
                   
                 ACTIVATION OF JNK 
               
               
                   
                 ACTIVITY 
               
               
                   
                 PEPTIDYL TYROSINE 
               
               
                   
                 MODIFICATION 
               
               
                   
                 PEPTIDYL TYROSINE 
               
               
                   
                 PHOSPHORYLATION 
               
               
                   
                 PROTEIN AMINO ACID 
               
               
                   
                 PHOSPHORYLATION 
               
               
                   
                 PHOSPHORYLATION 
               
               
                   
                 PROTEIN AMINO ACID 
               
               
                   
                 DEPHOSPHORYLATION 
               
               
                   
                 DEPHOSPHORYLATION 
               
               
                   
                 Cytokine production 
               
               
                   
                 CYTOKINE PRODUCTION 
               
               
                   
                 CYTOKINE METABOLIC 
               
               
                   
                 PROCESS 
               
               
                   
                 CYTOKINE BIOSYNTHETIC 
               
               
                   
                 PROCESS 
               
               
                   
                 REGULATION OF CYTOKINE 
               
               
                   
                 BIOSYNTHETIC PROCESS 
               
               
                   
                 Programmed cell death 
               
               
                   
                 APOPTOTIC PROGRAM 
               
               
                   
                 REGULATION OF 
               
               
                   
                 HYDROLASE ACTIVITY 
               
               
                   
                 POSITIVE REGULATION OF 
               
               
                   
                 HYDROLASE ACTIVITY 
               
               
                   
                 POSITIVE REGULATION OF 
               
               
                   
                 CASPASE ACTIVITY 
               
               
                   
                 CASPASE ACTIVATION 
               
               
                   
                 NEGATIVE REGULATION OF 
               
               
                   
                 DEVELOPMENTAL PROCESS 
               
               
                   
                 NEGATIVE REGULATION OF 
               
               
                   
                 APOPTOSIS 
               
               
                   
                 NEGATIVE REGULATION OF 
               
               
                   
                 PROGRAMMED CELL DEATH 
               
               
                   
                 ANTI APOPTOSIS 
               
               
                   
                 REGULATION OF 
               
               
                   
                 DEVELOPMENTAL PROCESS 
               
               
                   
                 REGULATION OF APOPTOSIS 
               
               
                   
                 REGULATION OF 
               
               
                   
                 PROGRAMMED CELL DEATH 
               
               
                   
                 APOPTOSIS 
               
               
                   
                 PROGRAMMED CELL DEATH 
               
               
                   
                 CELL DEVELOPMENT 
               
               
                   
                 POSITIVE REGULATION OF 
               
               
                   
                 DEVELOPMENTAL PROCESS 
               
               
                   
                 Mitosis 
               
               
                   
                 CYTOKINESIS 
               
               
                   
                 G1 S TRANSITION OF 
               
               
                   
                 MITOTIC CELL CYCLE 
               
               
                   
                 MITOTIC CELL CYCLE 
               
               
                   
                 M PHASE OF MITOTIC CELL 
               
               
                   
                 CYCLE 
               
               
                   
                 MITOSIS 
               
               
                   
                 REGULATION OF MITOSIS 
               
               
                   
                 Leukocyte activation 
               
               
                   
                 CELL ACTIVATION 
               
               
                   
                 LEUKOCYTE ACTIVATION 
               
               
                   
                 LYMPHOCYTE ACTIVATION 
               
               
                   
                 T CELL ACTIVATION 
               
               
                   
                 B CELL ACTIVATION 
               
               
                   
                 REGULATION OF 
               
               
                   
                 LYMPHOCYTE ACTIVATION 
               
               
                   
                 POSITIVE REGULATION OF 
               
               
                   
                 LYMPHOCYTE ACTIVATION 
               
               
                   
                 REGULATION OF T CELL 
               
               
                   
                 ACTIVATION 
               
               
                   
                 T CELL PROLIFERATION 
               
               
                   
                 LEUKOCYTE 
               
               
                   
                 DIFFERENTIATION 
               
               
                   
                 LYMPHOCYTE 
               
               
                   
                 DIFFERENTIATION 
               
               
                   
                 Homeostatic process 
               
               
                   
                 HOMEOSTASIS OF NUMBER 
               
               
                   
                 OF CELLS 
               
               
                   
                 REGULATION OF 
               
               
                   
                 BIOLOGICAL QUALITY 
               
               
                   
                 HOMEOSTATIC PROCESS 
               
               
                   
                 CHEMICAL HOMEOSTASIS 
               
               
                   
                 ION HOMEOSTASIS 
               
               
                   
                 CATION HOMEOSTASIS 
               
               
                   
                 CELLULAR CATION 
               
               
                   
                 HOMEOSTASIS 
               
               
                   
                 CELLULAR HOMEOSTASIS 
               
               
                   
                 Immune system development 
               
               
                   
                 HEMOPOIESIS 
               
               
                   
                 IMMUNE SYSTEM 
               
               
                   
                 DEVELOPMENT 
               
               
                   
                 HEMOPOIETIC OR 
               
               
                   
                 LYMPHOID ORGAN 
               
               
                   
                 DEVELOPMENT 
               
               
                   
                 MYELOID CELL 
               
               
                   
                 DIFFERENTIATION 
               
               
                   
                 Other 
               
               
                   
                 PROTEOLYSIS 
               
               
                   
                 CELLULAR LIPID 
               
               
                   
                 CATABOLIC PROCESS 
               
               
                   
                 LIPID CATABOLIC PROCESS 
               
               
                   
                 ORGANIC ACID METABOLIC 
               
               
                   
                 PROCESS 
               
               
                   
                 CARBOXYLIC ACID 
               
               
                   
                 METABOLIC PROCESS 
               
               
                   
                 MEMBRANE 
               
               
                   
                 ORGANIZATION AND 
               
               
                   
                 BIOGENESIS 
               
               
                   
                 RECEPTOR MEDIATED 
               
               
                   
                 ENDOCYTOSIS 
               
               
                   
                 PIGMENT BIOSYNTHETIC 
               
               
                   
                 PROCESS 
               
               
                   
                 PROTEIN COMPLEX 
               
               
                   
                 ASSEMBLY 
               
               
                   
                 REGULATION OF CELL 
               
               
                   
                 ADHESION 
               
               
                   
                 VIRAL REPRODUCTIVE 
               
               
                   
                 PROCESS 
               
               
                   
                 LIPID TRANSPORT 
               
               
                   
                 REGULATION OF 
               
               
                   
                 ANATOMICAL STRUCTURE 
               
               
                   
                 MORPHOGENESIS 
               
               
                   
                 REGULATION OF CELL 
               
               
                   
                 MORPHOGENESIS 
               
               
                   
                 ACTIN CYTOSKELETON 
               
               
                   
                 ORGANIZATION AND 
               
               
                   
                 BIOGENESIS 
               
               
                   
                 ACTIN FILAMENT BASED 
               
               
                   
                 PROCESS 
               
               
                   
                 POSITIVE REGULATION OF 
               
               
                   
                 TRANSLATION 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 6 
               
               
                   
               
               
                 Name 
                 Symbol 
               
               
                   
               
             
            
               
                 MAD2 mitotic arrest deficient-like 2 (yeast) 
                 MAD2L2 
               
               
                 olfactory receptor, family 2, subfamily A, member 7 
                 OR2A7 
               
               
                 tubulin tyrosine ligase-like family, member 7 
                 TTLL7 
               
               
                 G protein-coupled receptor 68 
                 GPR68 
               
               
                 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 
                 TCIRG1 
               
               
                 subunit A3 
               
               
                 PYD and CARD domain containing 
                 PYCARD 
               
               
                 SRY (sex determining region Y)-box 5 
                 SOX5 
               
               
                 thymidine phosphorylase /// outer dense fiber of sperm tails 3B 
                 TYMP /// ODF3B 
               
               
                 ribonuclease, RNase A family, k6 
                 RNASE6 
               
               
                 Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 
                 WAS 
               
               
                 proline rich 11 
                 PRR11 
               
               
                 acyl-CoA thioesterase 7 /// acyl-CoA thioesterase 7 pseudogene 
                 ACOT7 /// 
               
               
                   
                 LOC344967 
               
               
                 coactosin-like 1 ( Dictyostelium ) 
                 COTL1 
               
               
                 antigen identified by monoclonal antibody Ki-67 
                 MKI67 
               
               
                 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N- 
                 MGAT1 
               
               
                 acetylglucosaminyltransferase 
               
               
                 tumor necrosis factor, alpha-induced protein 2 
                 TNFAIP2 
               
               
                 hypothetical LOC349196 
                 LOC349196 
               
               
                 tweety homolog 3 ( Drosophila ) 
                 TTYH3 
               
               
                 cerebral cavernous malformation 2 
                 CCM2 
               
               
                 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor 
                 SERPINE1 
               
               
                 type 1), member 1 
               
               
                 adenosine monophosphate deaminase 2 (isoform L) 
                 AMPD2 
               
               
                 mannosidase, alpha, class 2B, member 1 
                 MAN2B1 
               
               
                 suppressor of cytokine signaling 3 
                 SOCS3 
               
               
                 G protein-coupled receptor kinase 6 
                 GRK6 
               
               
                 c-src tyrosine kinase 
                 CSK 
               
               
                 heme oxygenase (decycling) 1 
                 HMOX1 
               
               
                 histone cluster 1, H3b 
                 HIST1H3B 
               
               
                 T-cell activation RhoGTPase activating protein 
                 TAGAP 
               
               
                 colony stimulating factor 1 receptor 
                 CSF1R 
               
               
                 rhomboid 5 homolog 2 ( Drosophila ) 
                 RHBDF2 
               
               
                 minichromosome maintenance complex component 5 
                 MCM5 
               
               
                 TBC1 domain family, member 9 (with GRAM domain) 
                 TBC1D9 
               
               
                 chromosome 6 open reading frame 150 
                 C6orf150 
               
               
                 sulfiredoxin 1 homolog ( S. cerevisiae ) 
                 SRXN1 
               
               
                 chromosome 17 open reading frame 62 
                 C17orf62 
               
               
                 family with sequence similarity 111, member B 
                 FAM111B 
               
               
                 actin related protein 2/3 complex, subunit 1B, 41 kDa /// actin related 
                 ARPC1B /// 
               
               
                 protein 2/3 complex, subunit 1A, 41 kDa 
                 ARPC1A 
               
               
                 FYVE, RhoGEF and PH domain containing 2 
                 FGD2 
               
               
                 polo-like kinase 3 ( Drosophila ) 
                 PLK3 
               
               
                 chromosome 10 open reading frame 55 /// plasminogen activator, 
                 C10orf55 /// PLAU 
               
               
                 urokinase 
               
               
                 cysteinyl leukotriene receptor 2 
                 CYSLTR2 
               
               
                 intercellular adhesion molecule 3 
                 ICAM3 
               
               
                 signal transducer and activator of transcription 5A 
                 STAT5A 
               
               
                 protein kinase, AMP-activated, beta 2 non-catalytic subunit 
                 PRKAB2 
               
               
                 solute carrier family 15, member 3 
                 SLC15A3 
               
               
                 platelet-activating factor receptor 
                 PTAFR 
               
               
                 glucose-6-phosphate dehydrogenase 
                 G6PD 
               
               
                 hematopoietic cell-specific Lyn substrate 1 
                 HCLS1 
               
               
                 lymphocyte antigen 96 
                 LY96 
               
               
                 zinc finger, DHHC-type containing 18 
                 ZDHHC18 
               
               
                 zinc finger protein 507 
                 ZNF507 
               
               
                 hematological and neurological expressed 1 
                 HN1 
               
               
                 acid phosphatase 2, lysosomal 
                 ACP2 
               
               
                 spleen focus forming virus (SFFV) proviral integration oncogene spi1 
                 SPI1 
               
               
                 ethylmalonic encephalopathy 1 
                 ETHE1 
               
               
                 CKLF-like MARVEL transmembrane domain containing 7 
                 CMTM7 
               
               
                 family with sequence similarity 26, member F 
                 FAM26F 
               
               
                 KIAA1539 
                 KIAA1539 
               
               
                 chromosome 1 open reading frame 152 /// phosphodiesterase 4D 
                 C1orf152 /// 
               
               
                 interacting protein 
                 PDE4DIP 
               
               
                 melanoma antigen family A, 5 
                 MAGEA5 
               
               
                 aspartate beta-hydroxylase domain containing 2 
                 ASPHD2 
               
               
                 paired immunoglobin-like type 2 receptor alpha 
                 PILRA 
               
               
                 potassium voltage-gated channel, shaker-related subfamily, beta member 2 
                 KCNAB2 
               
               
                 interferon induced transmembrane protein 1 (9-27) 
                 IFITM1 
               
               
                 chromosome 7 open reading frame 41 
                 C7orf41 
               
               
                 interferon regulatory factor 8 
                 IRF8 
               
               
                 cathepsin Z 
                 CTSZ 
               
               
                 NFAT activating protein with ITAM motif 1 
                 NFAM1 
               
               
                 neutrophil cytosolic factor 4, 40 kDa 
                 NCF4 
               
               
                 kelch-like 23 ( Drosophila ) /// phosphatase, orphan 2 
                 KLHL23 /// 
               
               
                   
                 PHOSPHO2 
               
               
                 tumor necrosis factor (TNF superfamily, member 2) 
                 TNF 
               
               
                 ras homolog gene family, member G (rho G) 
                 RHOG 
               
               
                 interleukin 12 receptor, beta 1 
                 IL12RB1 
               
               
                 phosphatidylinositol 4-kinase type 2 alpha 
                 PI4K2A 
               
               
                 lectin, galactoside-binding, soluble, 9 
                 LGALS9 
               
               
                 matrix metallopeptidase 25 
                 MMP25 
               
               
                 EGFR-coamplified and overexpressed protein 
                 ECOP 
               
               
                 pim-1 oncogene 
                 PIM1 
               
               
                 sorting nexin 20 
                 SNX20 
               
               
                 alcohol dehydrogenase, iron containing, 1 
                 ADHFE1 
               
               
                 formin-like 1 
                 FMNL1 
               
               
                 chemokine (C—X—C motif) ligand 2 
                 CXCL2 
               
               
                 lymphocyte-specific protein 1 
                 LSP1 
               
               
                 major histocompatibility complex, class II, DR beta 9 (pseudogene) 
                 HLA-DRB9 
               
               
                 G protein-coupled receptor 18 
                 GPR18 
               
               
                 chemokine (C motif) ligand 1 
                 XCL1 
               
               
                 E2F transcription factor 3 
                 E2F3 
               
               
                 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 
                 TAP1 
               
               
                 secreted and transmembrane 1 
                 SECTM1 
               
               
                 myosin IF 
                 MYO1F 
               
               
                 lymphocyte-specific protein 1 pseudogene /// lymphocyte-specific protein 
                 LOC654342 /// 
               
               
                 1 pseudogene /// lymphocyte-specific protein 1 
                 LOC645166 /// 
               
               
                   
                 LSP1 
               
               
                 hypothetical protein LOC100127980 
                 LOC100127980 
               
               
                 protein tyrosine phosphatase, non-receptor type 6 
                 PTPN6 
               
               
                 hypothetical LOC440993 
                 LOC440993 
               
               
                 docking protein 1, 62 kDa (downstream of tyrosine kinase 1) 
                 DOK1 
               
               
                 DKFZp761E198 protein 
                 DKFZp761E198 
               
               
                 2′-5′-oligoadenylate synthetase 3, 100 kDa 
                 OAS3 
               
               
                 Abelson helper integration site 1 
                 AHI1 
               
               
                 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, 
                 MTHFD2 
               
               
                 methenyltetrahydrofolate cyclohydrolase 
               
               
                 SLAM family member 8 /// chromosome 1 open reading frame 204 
                 SLAMF8 /// 
               
               
                   
                 C1orf204 
               
               
                 Janus kinase 3 
                 JAK3 
               
               
                 solute carrier family 2 (facilitated glucose transporter), member 6 
                 SLC2A6 
               
               
                 dpy-19-like 2 pseudogene 1 ( C. elegans ) 
                 DPY19L2P1 
               
               
                 alanyl (membrane) aminopeptidase 
                 ANPEP 
               
               
                 interleukin 1 receptor, type II 
                 IL1R2 
               
               
                 potassium channel tetramerisation domain containing 5 
                 KCTD5 
               
               
                 CDC42 binding protein kinase alpha (DMPK-like) 
                 CDC42BPA 
               
               
                 early growth response 2 
                 EGR2 
               
               
                 complement component 5a receptor 1 
                 C5AR1 
               
               
                 transmembrane protein 149 
                 TMEM149 
               
               
                 phosphoinositide-3-kinase, catalytic, delta polypeptide 
                 PIK3CD 
               
               
                 G protein-coupled receptor 132 
                 GPR132 
               
               
                 phospholipase D family, member 3 
                 PLD3 
               
               
                 fermitin family homolog 3 ( Drosophila ) 
                 FERMT3 
               
               
                 FYN binding protein (FYB-120/130) 
                 FYB 
               
               
                 neutrophil cytosolic factor 1 /// similar to Neutrophil cytosol factor 1 
                 NCF1 
               
               
                 (NCF-1) (Neutrophil NADPH oxidase factor 1) 
               
               
                 phospholipase B domain containing 2 
                 PLBD2 
               
               
                 chemokine (C—X—C motif) ligand 16 
                 CXCL16 
               
               
                 myeloid differentiation primary response gene (88) 
                 MYD88 
               
               
                 serine/threonine kinase 17b 
                 STK17B 
               
               
                 nuclear factor (erythroid-derived 2)-like 3 
                 NFE2L3 
               
               
                 spleen tyrosine kinase 
                 SYK 
               
               
                 akirin 2 
                 AKIRIN2 
               
               
                 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte- 
                 CSF2RB 
               
               
                 macrophage) 
               
               
                 cubilin (intrinsic factor-cobalamin receptor) 
                 CUBN 
               
               
                 histone cluster 1, H1b 
                 HIST1H1B 
               
               
                 formyl peptide receptor 3 
                 FPR3 
               
               
                 interleukin 21 receptor 
                 IL21R 
               
               
                 purinergic receptor P2Y, G-protein coupled, 13 
                 P2RY13 
               
               
                 WD repeat domain 76 
                 WDR76 
               
               
                 asp (abnormal spindle) homolog, microcephaly associated ( Drosophila ) 
                 ASPM 
               
               
                 bone morphogenetic protein receptor, type IA 
                 BMPR1A 
               
               
                 SH3 domain and tetratricopeptide repeats 1 
                 SH3TC1 
               
               
                 twinfilin, actin-binding protein, homolog 2 ( Drosophila ) /// toll-like 
                 TWF2 /// TLR9 
               
               
                 receptor 9 
               
               
                 egf-like module containing, mucin-like, hormone receptor-like 2 
                 EMR2 
               
               
                 InaD-like ( Drosophila ) 
                 INADL 
               
               
                 RELT tumor necrosis factor receptor 
                 RELT 
               
               
                 integrin, alpha X (complement component 3 receptor 4 subunit) 
                 ITGAX 
               
               
                 multiple PDZ domain protein 
                 MPDZ 
               
               
                 macrophage expressed 1 
                 MPEG1 
               
               
                 zinc finger, DBF-type containing 2 
                 ZDBF2 
               
               
                 PX19 protein pseudogene 
                 LOC388955 
               
               
                 replication factor C (activator 1) 1, 145 kDa 
                 RFC1 
               
               
                 cofilin 1 (non-muscle) 
                 CFL1 
               
               
                 WD repeat domain 27 
                 WDR27 
               
               
                 PTK2B protein tyrosine kinase 2 beta 
                 PTK2B 
               
               
                 coronin, actin binding protein, 1A 
                 CORO1A 
               
               
                 interleukin 17 receptor A 
                 IL17RA 
               
               
                 NTF2-like export factor 1 
                 NXT1 
               
               
                 interferon gamma receptor 2 (interferon gamma transducer 1) 
                 IFNGR2 
               
               
                 CTAGE family, member 4 
                 CTAGE4 
               
               
                 integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated 
                 ITGAL 
               
               
                 antigen 1; alpha polypeptide) 
               
               
                 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 
                 TAP2 
               
               
                 G protein-coupled receptor 137B 
                 GPR137B 
               
               
                 C-type lectin domain family 10, member A 
                 CLEC10A 
               
               
                 G protein-coupled receptor 125 
                 GPR125 
               
               
                 hemopoietic cell kinase 
                 HCK 
               
               
                 S100 calcium binding protein A9 
                 S100A9 
               
               
                 family with sequence similarity 86, member A pseudogene 
                 hCG_1990547 
               
               
                 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 
                 ITGB2 
               
               
                 GEM interacting protein 
                 GMIP 
               
               
                 NLR family, pyrin domain containing 3 
                 NLRP3 
               
               
                 myeloid cell leukemia sequence 1 (BCL2-related) 
                 MCL1 
               
               
                 transcobalamin II; macrocytic anemia 
                 TCN2 
               
               
                 Rho family GTPase 1 
                 RND1 
               
               
                 colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte- 
                 CSF2RA 
               
               
                 macrophage) 
               
               
                 destrin (actin depolymerizing factor) 
                 DSTN 
               
               
                 olfactory receptor, family 7, subfamily E, member 13 pseudogene 
                 OR7E13P 
               
               
                 spectrin repeat containing, nuclear envelope 1 
                 SYNE1 
               
               
                 interleukin 10 receptor, alpha 
                 IL10RA 
               
               
                 WDFY family member 4 
                 WDFY4 
               
               
                 integrin, beta 7 
                 ITGB7 
               
               
                 CD6 molecule 
                 CD6 
               
               
                 thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) 
                 THRB 
               
               
                 oncogene homolog 2, avian) 
               
               
                 cyclin E1 
                 CCNE1 
               
               
                 ribonuclease T2 /// hypothetical protein LOC100131869 
                 RNASET2 /// 
               
               
                   
                 LOC100131869 
               
               
                 phosphoinositide-3-kinase adaptor protein 1 
                 PIK3AP1 
               
               
                 DNA cross-link repair 1B (PSO2 homolog,  S. cerevisiae ) 
                 DCLRE1B 
               
               
                 Prader-Willi/Angelman syndrome-5 
                 PAR5 
               
               
                 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 
                 ARAP1 
               
               
                 glucuronidase, beta 
                 GUSB 
               
               
                 hypothetical protein LOC100132014 /// laeverin 
                 LOC100132014 /// 
               
               
                   
                 LVRN 
               
               
                 Vac14 homolog ( S. cerevisiae ) 
                 VAC14 
               
               
                 transketolase 
                 TKT 
               
               
                 interferon regulatory factor 1 
                 IRF1 
               
               
                 cathepsin A 
                 CTSA 
               
               
                 lysosomal-associated membrane protein 1 
                 LAMP1 
               
               
                 immediate early response 5 
                 IER5 
               
               
                 furry homolog ( Drosophila ) 
                 FRY 
               
               
                 family with sequence similarity 72, member D 
                 FAM72D 
               
               
                 ATP-binding cassette, sub-family D (ALD), member 1 
                 ABCD1 
               
               
                 hepatitis A virus cellular receptor 2 
                 HAVCR2 
               
               
                 tumor necrosis factor receptor superfamily, member 10b 
                 TNFRSF10B 
               
               
                 aminolevulinate, delta-, synthase 1 
                 ALAS1 
               
               
                 chromosome 1 open reading frame 38 
                 C1orf38 
               
               
                 LIM domain kinase 1 
                 LIMK1 
               
               
                 interleukin 1, beta 
                 IL1B 
               
               
                 regulator of G-protein signaling 18 
                 RGS18 
               
               
                 solute carrier family 26, member 5 (prestin) 
                 SLC26A5 
               
               
                 sialic acid binding Ig-like lectin 7 
                 SIGLEC7 
               
               
                 major histocompatibility complex, class II, DQ beta 1 
                 HLA-DQB1 
               
               
                 Sec61 alpha 2 subunit ( S. cerevisiae ) 
                 SEC61A2 
               
               
                 regulator of G-protein signaling 1 
                 RGS1 
               
               
                 chromodomain helicase DNA binding protein 6 
                 CHD6 
               
               
                 adaptor-related protein complex 2, sigma 1 subunit 
                 AP2S1 
               
               
                 hypothetical LOC642980 
                 LOC642980 
               
               
                 SH3KBP1 binding protein 1 
                 SHKBP1 
               
               
                 CD5 molecule 
                 CD5 
               
               
                 chromosome 17 open reading frame 87 
                 C17orf87 
               
               
                 carboxypeptidase, vitellogenic-like 
                 CPVL 
               
               
                 C-type lectin domain family 6, member A 
                 CLEC6A 
               
               
                 proline-serine-threonine phosphatase interacting protein 2 
                 PSTPIP2 
               
               
                 chromosome 6 open reading frame 124 
                 C6orf124 
               
               
                 ADP-ribosylation factor-like 11 
                 ARL11 
               
               
                 transmembrane protein 224 
                 TMEM224 
               
               
                 C-type lectin domain family 7, member A 
                 CLEC7A 
               
               
                 solute carrier family 24 (sodium/potassium/calcium exchanger), member 6 
                 SLC24A6 
               
               
                 adenosine deaminase 
                 ADA 
               
               
                 NAD kinase 
                 NADK 
               
               
                 transmembrane protein 206 
                 TMEM206 
               
               
                 PRELI domain containing 1 /// PX19 protein pseudogene 
                 PRELID1 /// 
               
               
                   
                 LOC388955 
               
               
                 interleukin 27 receptor, alpha 
                 IL27RA 
               
               
                 basic helix-loop-helix family, member e40 
                 BHLHE40 
               
               
                 Fas apoptotic inhibitory molecule 3 
                 FAIM3 
               
               
                 immunoglobulin superfamily, member 6 
                 IGSF6 
               
               
                 ribosomal protein S6 kinase, 90 kDa, polypeptide 4 
                 RPS6KA4 
               
               
                 interleukin 8 receptor, beta 
                 IL8RB 
               
               
                 topoisomerase (DNA) II alpha 170 kDa 
                 TOP2A 
               
               
                 CMT1A duplicated region transcript 4 /// family with sequence similarity 
                 CDRT4 /// 
               
               
                 18, member B2 
                 FAM18B2 
               
               
                 solute carrier family 16, member 6 (monocarboxylic acid transporter 7) 
                 SLC16A6 
               
               
                 dipeptidyl-peptidase 9 
                 DPP9 
               
               
                 serine hydroxymethyltransferase 2 (mitochondrial) 
                 SHMT2 
               
               
                 C-type lectin domain family 9, member A 
                 CLEC9A 
               
               
                 G protein-coupled receptor 77 
                 GPR77 
               
               
                 membrane-associated ring finger (C3HC4) 1 
                 MAR_1 
               
               
                 jun B proto-oncogene 
                 JUNB 
               
               
                 G protein-coupled receptor 183 
                 GPR183 
               
               
                 chemokine (C motif) receptor 1 
                 XCR1 
               
               
                 transforming, acidic coiled-coil containing protein 3 
                 TACC3 
               
               
                 zinc finger protein 285A 
                 ZNF285A 
               
               
                 transforming growth factor, beta-induced, 68 kDa 
                 TGFBI 
               
               
                 Fc receptor-like 2 
                 FCRL2 
               
               
                 BCL2-related protein A1 
                 BCL2A1 
               
               
                 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM 
                 LILRB1 
               
               
                 domains), member 1 
               
               
                 elastin microfibril interfacer 2 
                 EMILIN2 
               
               
                 hydrogen voltage-gated channel 1 
                 HVCN1 
               
               
                 GLI-Kruppel family member HKR1 
                 HKR1 
               
               
                 chromosome 11 open reading frame 75 
                 C11orf75 
               
               
                 spermidine synthase 
                 SRM 
               
               
                 growth factor receptor-bound protein 2 
                 GRB2 
               
               
                 lymphocyte-specific protein tyrosine kinase 
                 LCK 
               
               
                 cytochrome b-245, alpha polypeptide 
                 CYBA 
               
               
                 SHC SH2-domain binding protein 1 
                 SHCBP1 
               
               
                 plasminogen activator, urokinase receptor 
                 PLAUR 
               
               
                 ABI family, member 3 
                 ABI3 
               
               
                 olfactory receptor, family 2, subfamily C, member 1 
                 OR2C1 
               
               
                 cathepsin B 
                 CTSB 
               
               
                 cyclin Y-like 1 
                 CCNYL1 
               
               
                 RUN domain containing 2C /// RUN domain containing 2B 
                 RUNDC2C /// 
               
               
                   
                 RUNDC2B 
               
               
                 histone cluster 1, H3j 
                 HIST1H3J 
               
               
                 nuclear factor of kappa light polypeptide gene enhancer in B-cells 
                 NFKBIE 
               
               
                 inhibitor, epsilon 
               
               
                 golgi autoantigen, golgin subfamily a, 2-like 1 
                 GOLGA2L1 
               
               
                 oral-facial-digital syndrome 1 
                 OFD1 
               
               
                 C-type lectin domain family 4, member E 
                 CLEC4E 
               
               
                 chromosome 2 open reading frame 14 
                 C2orf14 
               
               
                 zinc finger protein 250 
                 ZNF250 
               
               
                 checkpoint with forkhead and ring finger domains 
                 CHFR 
               
               
                 interleukin 2 receptor, gamma (severe combined immunodeficiency) 
                 IL2RG 
               
               
                 nucleolar and spindle associated protein 1 
                 NUSAP1 
               
               
                 granulin 
                 GRN 
               
               
                 prosaposin 
                 PSAP 
               
               
                 metadherin 
                 MTDH 
               
               
                 glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 
                 GRINA 
               
               
                 (glutamate binding) 
               
               
                 cytochrome P450, family 27, subfamily B, polypeptide 1 
                 CYP27B1 
               
               
                 syntaxin binding protein 4 
                 STXBP4 
               
               
                 Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 
                 FGR 
               
               
                 Z-DNA binding protein 1 
                 ZBP1 
               
               
                 procollagen-lysine 1,2-oxoglutarate 5-dioxygenase 1 
                 PLOD1 
               
               
                 zinc finger protein 608 
                 ZNF608 
               
               
                 tubulin, alpha 1c 
                 TUBA1C 
               
               
                 RAB7, member RAS oncogene family-like 1 
                 RAB7L1 
               
               
                 tumor necrosis factor receptor superfamily, member 1B 
                 TNFRSF1B 
               
               
                 nuclear receptor subfamily 1, group H, member 3 
                 NR1H3 
               
               
                 sialic acid binding Ig-like lectin 10 
                 SIGLEC10 
               
               
                 aurora kinase B 
                 AURKB 
               
               
                 CD72 molecule 
                 CD72 
               
               
                 chromosome 19 open reading frame 61 
                 C19orf61 
               
               
                 profilin 1 
                 PFN1 
               
               
                 CD209 molecule 
                 CD209 
               
               
                 GPRIN family member 3 
                 GPRIN3 
               
               
                 septin 6 
                 SEP_06 
               
               
                 mucolipin 2 
                 MCOLN2 
               
               
                 chromosome X open reading frame 42 
                 CXorf42 
               
               
                 guanylate binding protein 5 
                 GBP5 
               
               
                 integrin, alpha M (complement component 3 receptor 3 subunit) 
                 ITGAM 
               
               
                 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 
                 CHST2 
               
               
                 ATPase, Na+/K+ transporting, beta 3 polypeptide 
                 ATP1B3 
               
               
                 EF-hand calcium binding domain 2 
                 EFCAB2 
               
               
                 CD33 molecule 
                 CD33 
               
               
                 actin related protein 2/3 complex, subunit 4, 20 kDa /// tubulin tyrosine 
                 ARPC4 /// TTLL3 
               
               
                 ligase-like family, member 3 
               
               
                 tweety homolog 2 ( Drosophila ) 
                 TTYH2 
               
               
                 major histocompatibility complex, class II, DR beta 5 
                 HLA-DRB5 
               
               
                 inositol polyphosphate-5-phosphatase, 145 kDa 
                 INPP5D 
               
               
                 KIAA1328 
                 KIAA1328 
               
               
                 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 
                 LYN 
               
               
                 CD180 molecule 
                 CD180 
               
               
                 BMS1 pseudogene 4 
                 BMS1P4 
               
               
                 Rap guanine nucleotide exchange factor (GEF) 1 
                 RAPGEF1 
               
               
                 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) 
                 UBE2J1 
               
               
                 Epstein-Barr virus induced 3 
                 EBI3 
               
               
                 phosphoinositide-3-kinase, regulatory subunit 5 
                 PIK3R5 
               
               
                 CD74 molecule, major histocompatibility complex, class II invariant chain 
                 CD74 
               
               
                 ring finger protein 19B 
                 RNF19B 
               
               
                 interleukin 22 receptor, alpha 2 
                 IL22RA2 
               
               
                 major histocompatibility complex, class I, C /// major histocompatibility 
                 HLA-C /// HLA-B 
               
               
                 complex, class I, B 
               
               
                 olfactory receptor, family 51, subfamily I, member 2 
                 OR51I2 
               
               
                 superoxide dismutase 2, mitochondrial 
                 SOD2 
               
               
                 sialophorin 
                 SPN 
               
               
                 CD3g molecule, gamma (CD3-TCR complex) 
                 CD3G 
               
               
                 SLAM family member 7 
                 SLAMF7 
               
               
                 zinc finger protein 512 
                 ZNF512 
               
               
                 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein 
                 LCP2 
               
               
                 of 76 kDa) 
               
               
                 adrenergic, beta, receptor kinase 1 
                 ADRBK1 
               
               
                 sorting nexin 10 
                 SNX10 
               
               
                 prostaglandin D2 synthase 21 kDa (brain) 
                 PTGDS 
               
               
                 SAM and SH3 domain containing 3 
                 SASH3 
               
               
                 chemokine (C-C motif) receptor 7 
                 CCR7 
               
               
                 similar to mCG49427 
                 LOC100130130 
               
               
                 family with sequence similarity 27-like 
                 FAM27L 
               
               
                 osteoclast associated, immunoglobulin-like receptor 
                 OSCAR 
               
               
                 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 
                 NFKB2 
               
               
                 (p49/p100) 
               
               
                 inhibitor of growth family, member 5 
                 ING5 
               
               
                 lipoma HMGIC fusion partner-like 2 
                 LHFPL2 
               
               
                 selectin P ligand 
                 SELPLG