Patent Publication Number: US-7220783-B2

Title: Para-terphenyl compounds

Description:
This application is a Divisional of co-pending application Ser. No. 09/214,277 filed on Mar. 1, 1999 and for which priority is claimed under 35 U.S.C. § 120. application Ser. No. 09/214,277 is the national phase of PCT International Application No. PCT/JP97/02635 filed on Jul. 30, 1997 under 35 U.S.C. § 371. The entire contents of each of the above-identified applications are hereby incorporated by reference. This application also claims priority of Application No. 8-201859, 8-287782 and 9-86085 filed in Japan on Jul. 31, 1996, Oct. 30, 1996 and Mar. 18, 1997, respectively under 35 U.S.C. § 119. 
    
    
     TECHNICAL FIELD 
     The present invention relates to a novel para-terphenyl compound, a process for producing the same, a selective suppressor of the IgE production, an immunosuppressor and an anti-allergic agent. 
     BACKGROUND ART 
     A serious problem of a transplantation of a tissue or an organ which is frequently performed in recent years is a rejection symptom for excluding a transplanted part after an operation. Prevention of the rejection symptom is very important for a success of the transplantation. 
     Various immunosuppressors such as azathioprine, corticoid, Cyclosporin A, Tacrolimus and the like are developed and come into practical use for prevention and a treatment of a rejection symptom against a transplantation of an organ or a tissue or a graft-versus-host reaction which is caused by a bone marrow transplantation. But they are not so satisfactory in view of their effects and side effects. 
     Allergic diseases such as atopic dermatitis, allergic rhinitis, bronchial asthma, allergic conjunctivitis and the like globally tend to increase in recent years and become serious problems. The conventional antiinflammatory agents are suppressors of releasing chemical mediators from mast cells, receptor inhibitors of the chemical mediators released, suppressors of allergic inflammation reaction or the like. All of these are agents for symptomatic therapy and are not fundamental therapeutic agents for allergic diseases. 
     As an fundamental therapeutic agent for allergic diseases, a suppressor of the IgE antibody production has been expected. 
     One of compounds which have a suppressive effect on the IgE production is Suplatast Tosilate (IPD-1151-T). This is reported to act on T cell of type 2 (Th2 cell) to suppress the IL-4 production and to suppress a differentiation of B cells to IgE antibody-producing cells (Jpn. Pharmacol. (1993) 61, 31–39). 
     As compounds which directly act on B cells to suppress the IgE antibody production, for example, DSCG (Intal) or Nedcromil sodium which are degranulation inhibitors of mast cells are exemplified. These are reported to inhibit a class-switch of B cells (J. Exp. Med. (1994) 180: 663–671, J. Allergy Clin. Immunol. (1996) 97: 1141–1150). In J. Med. Chem. (1997) 40: 395–407, a compound which directly acts on B cells to suppress the IgE production is described. 
     Because immune globulins are necessary for phylaxis and a suppression of immune globulins other than IgE antibody is not preferable, an inhibitor which has a high selectivity to IgE and a potent effect has been desired. 
     The compounds which have an antiinflammatory effect and ortho-terphenyl structure are described in JP-A 60-13730, J. Med. Chem. (1996) 39: 1846–1856 and WO96/10012, and the compounds which have the same effect and biphenyl structure are described in JP-B 43-19935, JP-A 62-294650 and WO96/18606. 
     The compounds which have para-terphenyl structure are described in Chemical &amp; Pharmaceutical Bulletin, 24 (4), 613–620 (1976), The Journal of Antibiotics, 32 (6), 559–564 (1979) and Agricultural Biological Chemistry, 49 (3), 867–868 (1985) but an immunosuppressive or antiinflammatory effect of these compounds is not described at all. 
     DISCLOSURE INVENTION 
     An object of the present invention is to provide a selective suppressor of the IgE production, an immunosuppressor, and/or an anti-allergic agent which has a potent suppressive effect on the IgE production, an immunosuppressive effect and/or an anti-allergic effect. Other object of the present invention is to provide novel compounds which have the above effects and a process for producing the same. 
     The present invention provides a selective suppressor of the IgE production, an immunosuppressor and/or an anti-allergic agent comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which does not suppress or weakly sup presses the production of IgG, IgM and/or IgA which are produced at the same time. The present invention provides a method for selectively suppressing the IgE production or for suppressing an immune reaction or a method for treating and/or preventing allergic diseases comprising administering the compound. In another embodiment, the present invention provides use of the compound for the manufacture of a medicament for selectively suppressing the IgE production, suppressing the immune reaction or treating and/or preventing allergic diseases. 
     The present invention provides a compound of the formula (I) as an example of the compounds which has the above effects: 
     
       
         
         
             
             
         
       
         
         wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12  and R 13  are each independently hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted acyloxy, optionally substituted lower alkylsulfonyl, optionally substituted lower alkylsulfonyloxy, optionally substituted lower alkylsulfinyl, nitro, cyano, formyl, optionally substituted amino, optionally substituted carbamoyl, optionally substituted sulfamoyl or optionally substituted heterocyclyl, 
         X is —O—, —CH 2 —, —NR 14 — wherein R 14  is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl or acetyl, or —S(O)p- wherein p is an integer of 0 to 2, 
         Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl, and Y may optionally be substituted lower alkoxy when X is —CH 2 — and may optionally be substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is —O— or —NR 14 —, 
         R 1  and R 4 , R 1  and R 2 , R 2  and R 3 , R 4  and R 5 , R 6  and R 7 , R 8  and R 9 , R 8  and R 9 , R 10  and R 11 , R 12  and R 13 , R 11  and —X—Y, or R 13  and —X—Y taken together may form a 5- or 6-membered ring which may contain one or more of O, S or NR 15  wherein R 15  is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted arylsulfonyl and which may optionally be substituted, 
         excluding compounds wherein one or more of R 6 , R 7 , R 8  and R 9  are halogen and the others are hydrogen, all of R 6 , R 7 , R 8  and R 9  are halogen and all of R 2 –R 13  are hydrogen, halogen or cyano, 
         provided that R 1  is not hydrogen, fluorine, optionally substituted lower alkyl or optionally substituted lower alkoxy, all of R 2 , R 3 , R 4 , R 5  and R 12  are hydrogen, or R 13  is not hydrogen or halogen when R 6 , R 7 , R 8  and R 9  are all simultaneously hydrogen, and further provided that R 1  is not methyl or acetyloxy, R 13  is not hydrogen, optionally substituted lower alkoxycarbonyl or optionally substituted carbamoyl, or —X—Y is not methoxy when at least one of R 6 , R 7 , R 8  and R 9  is a substituent other than hydrogen, and excluding a compound of the formula (I′): 
       
    
                         
wherein R 1′  is hydrogen or hydroxy and R 13′  is hydroxy or methoxy, pharmaceutically acceptable salt, hydrate or prodrug thereof.
 
     The present invention provides a pharmaceutical composition, more specifically a selective suppressor of the IgE production, an immunosuppressor or an anti-allergic agent, comprising the compound (I), pharmaceutically acceptable salt, hydrate or prodrug thereof. 
     The present invention provides a selective suppressor of the IgE production, an immunosuppressor and/or an anti-allergic agent comprising a compound of the formula (I″): 
                         
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12  and R 13  are each independently hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted acyloxy, optionally substituted lower alkylsulfonyl, optionally substituted lower alkylsulfonyloxy, optionally substituted lower alkylsulfinyl, nitro, cyano, formyl, optionally substituted amino, optionally substituted carbamoyl, optionally substituted sulfamoyl or optionally substituted heterocyclyl,
     X is —O—, —CH 2 —, —NR 14 — wherein R 14  is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl or acetyl, or —S(O)p- wherein p is an integer of 0 to 2,   Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl, and Y may optionally be substituted lower alkoxy when X is —CH 2 — and may optionally be substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is —O— or —NR 14 —,   R 1  and R 4 , R 1  and R 2 , R 2  and R 3 , R 4  and R 5 , R 6  and R 7 , R 8  and R 9 , R 10  and R 11 , R 12  and R 13 , R 11  and —X—Y, or R 13  and —X—Y taken together may form a 5- or 6-membered ring which may contain one or more of O, S or NR 15  wherein R 15  is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl or optionally substituted arylsulfonyl and which may optionally be substituted, excluding a compound of the formula (I′):   
                         
wherein R 1′  is hydrogen or hydroxy and R 13′  is hydroxy or methoxy, pharmaceutically acceptable salt, hydrate or prodrug thereof.
 
     The present invention provides a method for selectively suppressing the IgE production, suppressing an immune reaction or treating or preventing allergic diseases comprising administering the compound (I) or (I″). In another embodiment, the present invention provides use of the compound (I) or (I″) for manufacturing of a medicament for selectively suppressing the IgE production, suppressing the immune reaction or treating or preventing allergic diseases. 
     In one of the other embodiments, the present invention provides a process for producing a compound of the formula (I′″): 
                         
the compound of the above formula (I) or (I′), pharmaceutically acceptable salt or hydrate thereof
     wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12  and R 13  are each independently hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted acyloxy, optionally substituted lower alkylsulfonyl, optionally substituted lower alkylsulfonyloxy, optionally substituted lower alkylsulfinyl, nitro, cyano, formyl, optionally substituted amino, optionally substituted carbamoyl, optionally substituted sulfamoyl or optionally substituted heterocyclyl,   X is —O—, —CH 9 —, —NR 14 — wherein R 14  is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl or acetyl, or —S(o)p- wherein p is an integer of 0 to 2,   Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl, and Y may optionally be substituted lower alkoxy when X is —CH 2 — and may optionally be substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is —O— or —NR 14 —,   R 1  and R 4 , R 1  and R 2 , R 2  and R 3 , R 4  and R 5 , R 6  and R 7 , R 8  and R 9 , R 10  and R 11 , R 12  and R 13 , R 11  and —X—Y, or R 13  and —X—Y taken together may form a 5- or 6-membered ring which may contain one or more of 0, S or NR 15  wherein R 15  is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted arylsulfonyl, and which may optionally be substituted,   excluding a compound wherein one or more of R 6 , R 7 , R 8  and R 9  are halogen and the others are hydrogen, all of R 6 , R 7 , R 8  and R 9  are halogen and all of R 2 –R 13  are hydrogen, halogen or cyano,   provided that R 1  is not hydrogen, fluorine; optionally substituted lower alkyl or optionally substituted lower alkoxy, all of R 2 , R 3 , R 4 , R 5  and R 12  are hydrogen or R 13  is not hydrogen or halogen when R 6 , R 7 , R 8  and R 9  are all simultaneously hydrogen, and further provided that R 1  is not methyl or acetyloxy, R 13  is not hydrogen, optionally substituted lower alkoxycarbonyl or optionally substituted carbamoyl or —X—Y is not methoxy when at least one of R 6 , R 7 , R 8  and R 9  is a substituent other than hydrogen, pharmaceutically acceptable salt or hydrate thereof, which comprises reacting a compound of the formula (II):   
                         
with a compound of the formula (III):
 
                         
wherein, in the formulas (II) and (III), R 1 –R 13 , X and Y are the same as defined in the above formula (I), either of A and Z is dihydroxyborane, di(lower)alkoxyborane, di(lower)alkylborane,
 
                         
and the other is halogen or —OSO 2 (C q F 2q+1 )— wherein q is an integer of 0 to 4, or reacting a compound of the formula (II′):
 
                         
with a compound of the formula (III′):
 
                         
wherein, in the formulas (II′) and (III′), R 1 –R 13 , X and Y are the same as defined in the above formula (I) and A and Z are the same as defined in the above formulas (II) and (III). As another process, the present invention provides a process for producing the compound of the above formula (I′″), (I) or (I′), pharmaceutically acceptable salt or hydrate thereof comprising the reaction of a compound of the formula (IV):
 
                         
with a compound of the formula (V):
 
                         
wherein, in the formulas (IV) and (V), R 1 –R 9  are the same as defined in the above formula (I), Z 1  is the same as Z defined in the above formula (II), A 1  and A 2  are each independently the same as A defined in the above formula (III) and the reactivity of A 1  is higher than or equal to that of A 2 ,
 
followed by the reaction with a compound of the formula (VI):
 
                         
wherein R 10 –R 13 , X and Y are the same as defined in the above formula (I) and Z 2  is the same as Z defined in the above formula (II) and a process for producing the compound of the above formula (I′″), (I) or (I′), pharmaceutically acceptable salt, hydrate thereof comprising the reaction of a compound of the formula (IV′):
 
                         
wherein R 6 –R 9  is the same as defined in the above formula (I), A 1  and A 2  are each independently the same as A defined in the above formula (III) and the reactivity of A 2  is higher than or equal to that of A 1 ,
 
with a compound of the above formula (VI), followed by the reaction with a compound of the above formula (V).
 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  shows an antibody production-suppressive effect on human peripheral lymphocytes of the compound (I-839) of the present invention. The ordinate represents a percentage of the amount of antibodies to that of antibodies which are produced in the absence of the compound. The abscissa represents a concentration of the compound. 
         FIG. 2  shows an antibody production-suppressive effect on human peripheral lymphocytes of the compound No. 36. The ordinate represents a percentage of the amount of antibodies to that of antibodies which are produced in the absence of the compound. The abscissa represents a concentration of the compound. 
         FIG. 3  shows an antibody production-suppressive effect on mouse spleen lymphocytes of the compound (I-967) of the present invention. The ordinate represents a percentage of the amount of antibodies to that of antibodies which are produced in the absence of the compound. The abscissa represents a concentration of the compound. 
         FIG. 4  shows a suppressive effect of the compound (I-963) of the present invention for an infiltration of inflammatory cells to irrigation water of pulmonary alveolus by an antigen stimulation on mice. The ordinate represents the number of inflammatory cells and the abscissa represents the number of total inflammatory cells, the number of macrophages, the number of eosinophils and the number of neutrophils. The white column represents a group inhaling saline instead of ovalbumin, the black column represents a group inhaling an antigen to cause inflammation and without administration of any compound of the present invention, and the gray column represents a group inhaling an antigen to cause inflammation with administration of the compound of the present invention. 
     
    
    
     BEST MODE FOR CARRYING OUT THE INVENTION 
     In the present specification, the term “halogen” includes fluorine, chlorine, bromine and iodine. Fluorine or chlorine is preferable. The halogen in the term “halogeno(lower)alkyl”, “halogeno(lower)alkenyl” and “halogenoaryl” is the same as above. 
     The term “lower alkyl” represents straight or branched chain alkyl having 1 to 10 carbon atoms, preferably 1 to 8 carbon atoms, more preferably 1 to 6 carbon atoms and most preferably 1 to 4 carbon atoms. For example, included are methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, hexyl, isohexyl, n-heptyl, isoheptyl, n-octyl, isooctyl, n-nonyl, n-decyl and the like. 
     As substituents of the “optionally substituted lower alkyl” in R 1 –R 13 , R 14  and R 15  exemplified are halogen; hydroxy; lower alkoxy optionally substituted with lower alkoxy; carboxy; lower alkoxycarbonyl; acyloxy and the like and the lower alkyl may be substituted with one or more of these substituents at any possible positions. 
     As substituents for “optionally substituted lower alkyl” in Y exemplified are halogen; hydroxy; carboxy; lower alkoxycarbonyl; lower alkoxy optionally substituted with lower alkoxy; acyl; acyloxy; amino optionally substituted with hydroxy or lower alkyl; imino optionally substituted with hydroxy, lower alkoxy, carboxy(lower)alkoxy, aryl(lower)alkoxy or heterocyclyl; hydrazono optionally substituted with carbamoyl or lower alkoxycarbonyl; cycloalkyl optionally substituted with lower alkyl; cycloalkenyl optionally substituted with lower alkyl; cyano; carbamoyl optionally substituted with lower alkyl or amino; thiocarbamoyl optionally substituted with lower alkyl; 
                         
wherein ring A represents cycloalkyl or heterocyclyl;
     aryl optionally substituted with lower alkyl, halogeno(lower)alkyl, carboxy(lower)alkyl, lower alkoxycarbonyl(lower)alkyl, halogen, hydroxy, lower alkoxy, carboxy, lower alkoxycarbonyl, lower alkenyloxycarbonyl, acyloxy, nitro, cyano, amino, lower alkoxycarbonylamino, acylamino, lower alkylsulfonylamino, lower alkylamino or guanidino; or   heterocyclyl optionally substituted with lower alkyl (optionally substituted with heterocyclyl), halogen, hydroxy, carboxy, lower alkoxycarbonyl, lower alkylsulfonyl, lower alkylarylsulfonyl, mercapto, lower alkylthio or heterocyclyl optionally substituted with aryl.   
     The alkyl part of “halogeno(lower)alkyl”, “hydroxy(lower)alkyl”, “carboxy(lower)alkyl”, “lower alkoxycarbonyl(lower)alkyl”, “lower alkylthio”, “lower alkylamino”, “lower alkylsulfonyl”, “lower alkylsulfonyloxy”, “lower alkylsulfonylamino”, “lower alkylsulfinyl”, “lower alkylaryl”, “lower alkylarylsulfonyl”, “di(lower)alkylcarbamoyl”, “di(lower)alkylborane”, “lower alkoxy”, “carboxy(lower)alkoxy”, “aryl(lower)alkoxy”, “lower alkoxy(lower)alkoxy”, “lower alkoxyaryl” or “di(lower)alkoxyborane” is the same as defined in the above “lower alkyl”. As substituents in the case of being “optionally substituted” exemplified are halogen; hydroxy; lower alkoxy; carboxy; lower alkoxycarbonyl; acyloxy; cycloalkyl; aryl optionally substituted with lower alkyl; heterocyclyl and the like. These substituents may substitute at one or more of any possible positions. 
     The part of lower alkyl in “lower alkoxycarbonyl” is the same as the above defined “lower alkyl” and substituents for “optionally substituted lower alkoxycarbonyl” are the same as those for the above “optionally substituted lower alkoxy”. 
     The part of “lower alkoxycarbonyl” in “lower alkoxycarbonyl(lower)alkyl”, “lower alkoxycarbonyl(lower)alkenyl” or “lower alkoxycarbonylamino” is the same as the above defined “lower alkoxycarbonyl”. 
     The term “lower alkenyl” represents straight or branched chain alkenyl having 2 to 10 carbon atoms, preferably 2 to 8 carbon atoms and more preferably 3 to 6 carbon atoms. For example, included are vinyl, propenyl, isopropenyl, butenyl, isobutenyl, butadienyl, pentenyl, isopentenyl, pentadienyl, hexenyl, isohexenyl, hexadienyl, heptenyl, octenyl, nonenyl, decenyl and the like and these have one or more double bonds at any possible positions. Substituents for “optionally substituted lower alkenyl” are the same as that for the above “optionally substituted lower alkoxy”. 
     The part of lower alkenyl in “lower alkoxycarbonyl(lower)alkenyl”, “halogeno(lower)alkenyl”, “lower alkenyloxy”, “lower alkenyloxycarbonyl” or “lower alkenylamino” is the same as the above defined “lower alkenyl”. 
     Substituents for “optionally substituted lower alkenyloxy” are the same as those for the above “optionally substituted lower alkoxy”. 
     The term “lower alkynyl” represents straight or branched chain alkynyl having 2 to 10 carbon atoms, preferably 2 to 8 carbon atoms and more preferably 3 to 8 carbon atoms. Specifically, included are ethynyl, propynyl, butynyl, pentynyl, hexynyl, heptynyl, octynyl, nonyl, decynyl and the like. These have one or more triple bonds at any possible positions and may further have a double bond. Substituents for “optionally substituted lower alkynyl” are the same as those for the above “optionally substituted lower alkoxy”. 
     The term “acyl” represents aliphatic acyl which includes chain acyl having 1 to 10 carbon atoms, preferably 1 to 8 carbon atoms, more preferably 1 to 6 carbon atoms, most preferably 1 to 4 carbon atoms and cyclic acyl having 3 to 8 carbon atoms, preferably 3 to 6 carbon atoms, and aroyl. Specifically, included are formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, pivaloyl, hexanoyl, acryloyl, propioloyl, methacryloyl, crotonoyl, cyclohexanecarbonyl, benzoyl and the like. Substituents for “optionally substituted acyl” are the same as those for “optionally substituted lower alkoxy” and aroyl may further be substituted with lower alkyl. 
     The part of acyl in “acyloxy” or “acylamino” is the same as the above identified “acyl” and substituents for “optionally substituted acyloxy” are the same as those for the above “optionally substituted acyl”. 
     The term “cycloalkyl” represent cyclic hydrocarbon having 3 to 6 carbon atoms and includes, for example, cyclopropyl, cyclobutyl, cyclopentyl cyclohexyl and the like. As substituents for “optionally substituted cycloalkyl” exemplified are lower alkyl, halogen, hydroxy, carboxy, lower alkoxycarbonyl, lower alkoxy, aryl, heterocyclyl and the like and the cycloalkyl may be substituted at any possible positions. 
     The term “cycloalkenyl” represents the group having one or more double bonds at any possible positions in the above cycloalkyl and included are, for example, cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, cyclohexadienyl and the like. Substituents for “optionally substituted cycloalkenyl” are the same as those for the above identified “cycloalkyl”. 
     The term “optionally substituted amino” includes substituted amino and unsubstituted amino and substituents exemplified are lower alkyl optionally substituted with lower alkylaryl etc.; lower alkenyl optionally substituted with halogen; lower alkylsulfonyl; lower alkylarylsulfonyl; lower alkoxycarbonyl; sulfamoyl; acyl optionally substituted with halogen; carbamoyl and the like. 
     The term “optionally substituted carbamoyl” includes substituted carbamoyl and unsubstituted carbamoyl and substituents exemplified are lower alkyl; lower alkylsulfonyl; sulfamoyl; acyl optionally substituted with halogen; amino and the like. 
     The term “optionally substituted sulfamoyl” includes substituted sulfamoyl and unsubstituted sulfamoyl and substituents exemplified are lower alkyl optionally substituted with aryl; lower alkenyl and the like. 
     The term “aryl” includes phenyl, naphthyl, anthryl, indenyl, phenanthryl and the like. Substituents for “optionally substituted aryl” exemplified are lower alkyl optionally substituted with halogen or carboxy; hydroxy; halogen; lower alkoxy; lower acyloxy; carboxy; lower alkoxycarbonyl; lower alkenyloxycarbonyl; amino optionally substituted with lower alkyl, lower alkylsulfonyl, lower alkoxycarbonyl or acyl; guanidino; nitro; aryl; heterocyclyl and the like and “optionally substituted aryl” may be substituted with one or more of these substituents at any possible positions. 
     The part of aryl in “lower alkylaryl”, “halogenoaryl”, “lower alkoxyaryl”, “arylsulfonyl”, “aryl(lower)alkoxy”, “lower alkylarylsulfonyl”, “heterocyclyl substituted with aryl”, “aroyl” or “aroyloxy” is the same as the above “aryl” and the substituents for “optionally substituted” are also the same as those for in the above “optionally substituted aryl”. 
     The term “heterocyclyl” represents a heterocyclic group which contains one or more of hetero atoms arbitrarily selected from a group of O, S and N and exemplified are 5- or 6-membered aromatic heterocyclyl such as pyrrolyl, imidazolyl, pyrazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazolyl, triazinyl, isoxazolyl, oxazolyl, oxadiazolyl, isothiazolyl, thiazolyl, thiaziazolyl, furyl, thienyl etc., condensed aromatic heterocyclyl such as indolyl, carbazolyl, acridinyl, benzimidazolyl, indazolyl, indolizinyl, quinolyl, isoquinolyl, cinnolinyl, phthalazinyl, quinazolinyl, naphthyridinyl, quinoxalinyl, purinyl, pteridinyl, benzisoxazolyl, benzoxazolyl, benzoxadiazolyl, benzisothiazolyl, benzothiazolyl, benzothiaziazolyl, benzofuryl, benzothienyl, benzotriazolyl etc., and alicyclic heterocyclyl such as dioxanyl, thiiranyl, oxiranyl, oxathioranyl, azetidinyl, thianyl, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, pyrazolinyl, piperidyl, piperazinyl, morpholinyl etc. As substituents for “optionally substituted heterocyclyl” exemplified are lower alkyl, lower alkenyl, hydroxy, halogen, carboxy, lower alkoxycarbonyl, lower alkoxy, mercapto, lower alkylthio, lower alkylsulfonyl, aryl, heterocyclyl and the like and the heterocyclyl may be substituted with one or more of these substituents at any possible positions. The part of heterocycle in “heterocyclyl substituted with aryl” is the same as the above “heterocyclyl”. 
     The term “5- or 6-membered ring which may contain one or more of 0, S or NR 15  and may optionally be substituted” represents a 5- or 6-membered ring which is formed by R 1  and R 4 , R 1  and R 2 , R 2  and R 3 , R 4  and R 5 , R 6  and R 7 , R 8  and R 9 , R 10  and R 11 , R 12  and R 13 , R 11  and —X—Y, or R 13  and —X—Y with the two carbon atoms constituting phenyl to which the above substituents are attached. For example, the above substituents taken together form —(CH 2 ) 3 —, —(CH 2 ) 4 —, —O(CH 2 ) m O—, —O(CH 2 ) n —, —(CH 2 ) n O—, —S(CH 2 ) m S—, —S(CH 2 ) n —, —(CH 2 ) n S—, —NR 15 (CH 2 ) m NR 15 , —NR 15 (CH 2 ) n —, —(CH 2 ) n NR 15 —, —O(CH 2 ) m S—, —S(CH 2 ) m O—, —S(CH 2 ) m NR 15 , —NR 15 (CH 2 ) m S—, —O(CH 2 ) m NR 15 —, —NR 15 (CH 2 ) m O—, —O—CH═CH—, —CH═CH—O—, —S—CH═CH—, —CH═CH—S—, —NR 15 —CH═CH—, —CH═CH—NR 15 —, —S—CH═N—, —N═CH—S—, —S—N═CH—, —CH═N—S—, —O—CH═N—, —N═CH—O—, —O—N═CH—, —CH═N—O—, —NR 15 —CH═N—, —N═CH—NR 15 —, —NR 15 —N═CH—, —CH═N—NR 15 —, —N═CH—CH═CH—, —CH═CH—CH═N—, —N═N—CH═CH—, —CH═CH—N═N—, —N═CH—N═CH—, —CH═N—CH═N—, —N═CH—CH═N— (m is 1 or 2 and n is 2 or 3) or the like and further these and the two carbon atoms constituting phenyl taken together form a 5- or 6-membered ring. These rings may be substituted with one or more of hydroxy; halogen; lower alkyl optionally substituted with lower alkoxycarbonyl or heterocyclyl; lower alkenyl optionally substituted with halogen; lower alkyliden optionally substituted with halogen; or the like. The substituents of “5- or 6-membered ring which may contain one or more of 0 or NR 15  and may optionally be substituted”, “5- or 6-membered ring which contains one or more of 0 or NR 15  and may optionally be substituted” and “5- or 6-membered ring which contains one or more of 0 and may optionally be substituted” are the same as the above unless otherwise defined. 
     The term “lower alkylidene” represents straight or branched alkylidene having 1 to 6 carbon atoms, preferably 1 to 4 carbon atoms, more preferably 1 to 3 carbon atoms and includes, for example, methylene, ethylidene, isopropylidene, vinylidene, methylidyne and the like. 
     The term “all of R 2 –R 13  are hydrogen, halogen or cyano” represents, for example, the case that R 2 –R 13  are the same or different and hydrogen, halogen or cyano. For example, included are the case that all of R 2 –R 13  are hydrogen, the case that all of them are halogen, the case that some are halogen and the others are hydrogen, the case that some are cyano and the others are hydrogen, the case that some are halogen, some are cyano and the others are hydrogen and the like. 
     The term “compound (I)”, “compound (I″)” or “compound (I′″)” also includes formable and pharmaceutically acceptable salts of each compounds. As “the pharmaceutically acceptable salt”, exemplified are salts with mineral acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, hydrofluoric acid, hydrobromic acid and the like; salts with organic acids such as formic acid, acetic acid, tartaric acid, lactic acid, citric acid, fumaric acid, maleic acid, succinic acid and the like; salts with organic bases such as ammonium, trimethylammonium, triethylammonium and the like; salts with alkaline metals such as sodium, potassium and the like and salts with alkaline earth metals such as calcium, magnesium and the like. 
     The compound of the present invention includes hydrates and all of stereoisomers, for example, atropisomers etc. thereof. 
     The compound of the present invention includes prodrugs thereof. The term “prodrug” means a group of compounds which are easily changeable to the compounds (I) or (I″) which have activities in living bodies. The prodrug may be prepared by usual reactions. As usual methods for producing prodrugs exemplified is the substitution of hydroxy by acyloxy substituted with carboxy, sulfo, amino, lower alkylamino or the like, phosphonoxy or the like. The substitution of hydroxy attached to R 1  by —OCOCH 2 CH 2 COOH, —OCOCH═CHCOOH, —OCOCH 2 SO 3 H, —OPO 3 H 2 , —OCOCH 2 NMe 2 , —OCO-Pyr (Pyr is pyridine) or the like is preferable. 
     In the present specification, the term “compound (I)” represents a group comprising novel compounds excluding the compound (I′), the term “compound (I″)” represents a group comprising the compound (I) and known compounds and the term “compound (I′″)” represents a group comprising the compound (I) and the compound (I′). 
     All of the compounds (I) and (I″) have a suppressive effect on the IgE production, an immunosuppressive effect and/or an anti-allergic effect and the following compounds are specifically preferable. 
     In the formulas (I) and (I″),
     1) a compound wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12  and R 13  are each independently hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted acyloxy, optionally substituted lower alkylsulfonyloxy, formyl, optionally substituted amino, optionally substituted carbamoyl or optionally substituted sulfamoyl,   X is —O—, —CH 2 —, —NR 14 — wherein R 14  is hydrogen or optionally substituted lower alkyl, or —S(O)p- wherein p is an integer of 0 to 2,   Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl or optionally substituted cycloalkenyl, and   R 1  and R 4 , R 1  and R 2 , R 8  and R 9 , R 11  and —X—Y, or R 13  and —X—Y taken together may form a 5- or 6-membered ring which may contain one or more of O or NR 15 ,   2) a compound wherein R 1  is hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, lower alkylsulfonyl, formyl, optionally substituted amino, lower alkylsulfinyl, acyloxy, nitro, cyano, optionally substituted sulfamoyl or heterocyclyl,   R 2  is hydrogen, hydroxy, halogen, optionally substituted lower alkyl or optionally substituted lower alkylsulfonyloxy,   R 3  is hydrogen, hydroxy, halogen or optionally substituted lower alkoxy,   R 4  is hydrogen, optionally substituted lower alkyl, halogen, optionally substituted lower alkoxy, nitro or optionally substituted amino,   R 5  is hydrogen, optionally substituted lower alkoxy, lower alkoxycarbonyl or carboxy,   R 6  is hydrogen, halogen, optionally substituted lower alkyl, carboxy, lower alkoxycarbonyl, nitro, formyl, amino or lower alkylsulfonyloxy,   R 7  and R 8  are each independently hydrogen, halogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, formyl or optionally substituted amino,   R 9  is hydrogen, hydroxy, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, formyl, optionally substituted carbamoyl or optionally substituted amino,   R 10  is hydrogen or lower alkoxy,   R 11  is hydrogen, halogen, optionally substituted lower alkyl, carboxy, lower alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, formyl, nitro or amino,   R 12  is hydrogen,   R 13  is hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyloxy, optionally substituted acyloxy, optionally substituted lower alkylsulfonyloxy, formyl, nitro or optionally substituted amino, and further R 13  may be hydrogen in the formula (I″),   Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl or optionally substituted cycloalkenyl and Y may be optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is —O— or —NR 14 —, and   R 1  and R 2 , R 1  and R 4 , R 8  and R 9 , R 11  and —X—Y, or R 13  and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted,   3) a compound wherein R 1  is hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, lower alkylsulfonyl, formyl, optionally substituted amino, lower alkylsulfinyl, acyloxy, nitro, cyano, optionally substituted sulfamoyl or heterocyclyl (hereinafter referred to as “R 1  is R1-1”) or R 1  and R 2  or R 4  taken together form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted,   preferably R 1  is hydrogen, hydroxy, halogen, optionally substituted lower alkoxy, optionally substituted lower alkenyloxy, optionally substituted lower alkylsulfonyloxy, optionally substituted amino, optionally substituted sulfamoyl (hereinafter referred to as   “R 1  is R1-2”), or R 1  and R 2  or R 4  taken together form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted,   more preferably, R 1  is hydrogen, hydroxy, halogen, lower alkoxy(lower)alkoxy, aryl(lower)alkoxy, lower alkenyloxy, lower alkylsulfonyloxy, amino, lower alkylamino or lower alkenylamino (hereinafter referred to as “R 1  is R1-3”), or R 1  and R 2  or R 4  taken together form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted, most preferably, R 1  is hydrogen, hydroxy, chlorine, fluorine, methoxymethyloxy, benzyloxy, 3-methyl-2-butenyloxy, methanesulfonyloxy, amino, dimethylamino or 3-methyl-2-butenylamino (hereinafter referred to as “R 1  is R1-4”), or R 1  and R 2  or R 4  taken together form —OCH 2 O— or —CH═CH—NH—,   4) a compound wherein R 2  is hydrogen, hydroxy, halogen, lower alkyl or optionally substituted lower alkylsulfonyloxy (hereinafter referred to as “R 2  is R2-1”) or R 1  and R 2  taken together form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted, preferably R 2  is hydrogen, halogen or alkyl having 1 to 3 carbon atoms (hereinafter referred to as “R 2  is R2-2”),   5) a compound wherein R 3  is hydrogen, hydroxy, halogen or optionally substituted lower alkoxy (hereinafter referred to as “R 3  is R3-1”), preferably R 3  is hydrogen or halogen (hereinafter referred to as “R 3  is R3-2”), more preferably R 3  is hydrogen or fluorine (hereinafter referred to as “R 3  is R3-3”),   6) a compound wherein R 4  is hydrogen, optionally substituted lower alkyl, halogen, optionally substituted lower alkoxy, nitro or optionally substituted amino (hereinafter referred to as “R 4  is R4-1”) or R 4  and R 1  taken together may form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted,   preferably R 4  is hydrogen, lower alkyl, lower alkoxy or halogen (hereinafter referred to as “R 4  is R4-2”), or R 4  and R 1  taken together may form —OCH 2 O—,   7) a compound wherein R 5  is hydrogen, optionally substituted lower alkoxy, lower alkoxycarbonyl or carboxy (hereinafter referred to as “R 5  is R5-1”), preferably R 5  is hydrogen, lower alkoxycarbonyl or carboxy (hereinafter referred to as “R 5  is R5-2”), more preferably R 5  is hydrogen (hereinafter referred to as “R 5  is R5-3”),   8) a compound wherein R 6  is hydrogen, halogen, optionally substituted lower alkyl, carboxy, lower alkoxycarbonyl, nitro, formyl, amino or lower alkylsulfonyloxy (hereinafter referred to as “R 6  is R6-1”),   preferably R 6  is hydrogen or lower alkyl or halogen (hereinafter referred to as “R 6  is R6-2”),   more preferably R 6  is hydrogen, alkyl having 1 to 3 carbon atoms or halogen (hereinafter referred to as “R 6  is R6-3”),   9) a compound wherein R 7  is hydrogen, halogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, formyl or optionally substituted amino (hereinafter referred to as “R 7  is R7-1”),   preferably R 7  is hydrogen, lower alkyl or lower alkoxy (hereinafter referred to as “R 7  is R7-9”),   10) a compound wherein R 8  is hydrogen, halogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, formyl or optionally substituted amino (hereinafter referred to as “R 8  is R8-1”) or R 8  and R 9  taken together may form a 5- or 6-membered ring which contains one or more of O and which may optionally be substituted, preferably R 8  is hydrogen, lower alkyl or lower alkoxy (hereinafter referred to as “R 8  is R8-2”),   11) a compound wherein R 9  is hydrogen, hydroxy, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, formyl, optionally substituted carbamoyl or optionally substituted amino (hereinafter referred to as “R 9  is R9-1”) or R 9  and R 8  taken together may form a 5- or 6-membered ring which contains one or more of O and which may optionally be substituted,   preferably R 9  is hydrogen, hydroxy, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, formyl, optionally substituted carbamoyl or optionally substituted amino (hereinafter referred to as “R 9  is R9-2”),   more preferably R 9  is hydrogen, hydroxy, lower alkyl, hydroxy(lower)alkyl, lower alkoxycarbonyl(lower)alkenyl, lower alkoxy(lower)alkoxy, lower alkylsulfonyloxy, di(lower)alkylcarbamoyl, carboxy, lower alkoxycarbonyl or amino (hereinafter referred to as “R 9  is R9-3”),   most preferably R 9  is hydrogen, hydroxy, methyl, hydroxymethyl, ethoxycarbonylvinyl, methoxymethyloxy, methanesulfonyl, dimethylcarbamoyl, carboxy, methoxycarbonyl or amino (hereinafter referred to as “R 9  is R9-4”),   12) a compound wherein R 10  is hydrogen or lower alkoxy (hereinafter referred to as “R 10  is R10-1”), preferably R 10  is hydrogen (hereinafter referred to as “R 10  is R10-2”),   13) a compound wherein RI 1  is hydrogen, halogen, optionally substituted lower alkyl, carboxy, lower alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, formyl, nitro or amino (hereinafter referred to as “R 11  is R11-1”) or R 11  and —X—Y taken together form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted with lower alkenyl, halogeno(lower)alkenyl or the like,   preferably R 11  is hydrogen or halogen (hereinafter referred to as “R 11  is R11-2”),   14) a compound wherein R 12  is hydrogen,   15) a compound wherein R 13  is hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyloxy, optionally substituted acyloxy, optionally substituted lower alkylsulfonyloxy, formyl, nitro or optionally substituted amino (hereinafter referred to as “R 13  is R13-1”) or R 13  and —X—Y taken together form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted with lower alkenyl, halogeno(lower)alkenyl or the like,   preferably R 13  is hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted acyloxy, optionally substituted lower alkylsulfonyloxy, formyl or optionally substituted amino (hereinafter referred to as “R 13  is R13-2”),   more preferably R 13  is hydroxy; halogen; lower alkyl optionally substituted with hydroxy or halogen; lower alkoxy optionally substituted with lower alkoxycarbonyl or lower alkoxy; lower alkenyloxy optionally substituted with halogen; aroyloxyl; lower alkylsulfonyloxy; formyl or amino (hereinafter referred to as “R 13  is R13-3”), most preferably R 13  is hydroxy, fluorine, methyl, hydroxymethyl, iodomethyl, methoxy, ethoxy, isopropyloxy, ethoxycarbonylmethyloxy, methoxymethyloxy, chlorobutenyloxy, bromopropenyloxy, chloropropenyloxy, bromobutenyloxy, dichloropropenyloxy, ethoxycarbonyl, benzoyloxy, methanesulfonyloxy, formyl or amino (hereinafter referred to as “R 13  is R13-4”),   16) a compound wherein X is —O—, —NR 14 — or —S(O)p- wherein p is an integer of 0 to 2 (hereinafter referred to as “X is X1”), or X, R 13  and Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and may optionally be substituted,   preferably X is —O—, —NH—, —NMe— or —SO 2 — (hereinafter referred to as “X is X2”), more preferably X is —O—, —NH—or —NMe— (hereinafter referred to as “X is X3”), most preferably X is —O—,   17) a compound wherein Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted cycloalkenyl, lower alkylsulfonyl, optionally substituted arylsulfonyl, lower alkoxycarbonyl or optionally substituted acyl (hereinafter referred to as “Y is Y1”), or Y, R 13  and X taken together may form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted, preferably Y is lower alkyl optionally substituted with halogen; hydroxy; amino optionally substituted with lower alkyl; lower alkoxy; carboxy; lower alkoxycarbonyl; acyl; cycloalkyl; cycloalkenyl; cyano; imino optionally substituted with hydroxy, lower alkoxy, carboxy(lower)alkoxy, aryl(lower)alkoxy or heterocyclyl; hydrazono optionally substituted with carbamoyl or lower alkoxycarbonyl; carbamoyl optionally substituted with lower alkyl or amino; thiocarbamoyl optionally substituted with lower alkyl; aryl optionally substituted with amino (optionally substituted with lower alkyl, acyl, lower alkoxycarbonyl or lower alkylsulfonyl), nitro, acyloxy, lower alkyl (optionally substituted with halogen or carboxy), halogen, lower alkoxy, carboxy, lower alkoxycarbonyl, lower alkenyloxycarbonyl or guanidino; or heterocyclyl optionally substituted with halogen or lower alkyl; lower alkenyl optionally substituted with halogen, hydroxy, cycloalkyl, lower alkoxycarbonyl or aryl-substituted heterocyclyl; lower alkynyl optionally substituted with halogen; or cycloalkenyl (hereinafter referred to as “Y is Y2”),   more preferably Y is lower alkyl optionally substituted with lower alkoxycarbonyl, aryl, lower alkylaryl, halogenoaryl, lower alkoxyaryl, heterocyclyl or acyl; or lower alkenyl optionally substituted with hydroxy, halogen or aryl (hereinafter referred to as “Y is Y3”),   most preferably Y is isopropyl, ethoxycarbonylmethyl, benzyl, methylphenylmethyl, fluorophenylmethyl, dichlorophenylmethyl, methoxyphenylmethyl, pyridylmethyl, benzoylmethyl, propenyl, methylpropenyl, methylbutenyl, hydroxymethylbutenyl, pentenyl, methylpentenyl, dimethyloctadienyl, chloropropenyl, dichloropropenyl, bromopropenyl, dibromopropenyl, fluoropropenyl, difluoropropenyl, butenyl, bromobutenyl, chlorobutenyl or phenylpropenyl (hereinafter referred to as “Y is Y4”),   18) a compound wherein R 1  is R1-2, R 2  is R2-1, R 3  is R3-1, R 4  is R4-1, R 5  is R5-1, R 6  is R6-1, R 7  is R7-1, R 8  is R8-1, R 9  is R9-2, R 10  is R10-1, R 11  is R11-1, R 12  is hydrogen, R 13  is R13-1, X is X1 and Y is Y1, and R 1  and R 2 , R 1  and R 4 , R 8  and R 9 , or R 13  and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted,   19) a compound wherein R 1  is R1-2, R 2  is R2-1, R 3  is R3-1, R 4  is R4-1, R 5  is R5-1, R 6  is R6-1, R 7  is R7-1, R 8  is R8-1, R 9  is R9-1, R 10  is R10-1, R 11  is R11-1, R 12  is hydrogen R 13  is R13-2, X is X1 and Y is Y1, and R 1  and R 2 , R 1  and R 4 , R 8  and R 9 , or R 13  and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted,   20) a compound wherein R 1  is R1-2, R 2  is R2-1, R 3  is R3-1, R 4  is R4-1, R 5  is R5-1, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-1, R 10  is R10-1, R 11  is R11-1, R 12  is hydrogen R 13  is R13-1, X is X1 and Y is Y2, and R1 and R 2 , R 1  and R 4 , R 8  and R 9 , or R 13  and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted,   21) a compound wherein R 1  is R1-1, R 2  is R2-1, R 3  is R3-1, R 4  is R4-1, R 5  is R5-1, R 6  is R6-2, R 7  is R7-1, R 8  is R8-2, R 9  is R9-2, R 10  is R10-1, R 11  is R11-1, R 12  is hydrogen, R 13  is R13-2, X is X1 and Y is Y1, and R 1  and R 2 , R 1  and R 4 , R 8  and R 9 , or R 13  and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted,   22) a compound wherein R 1  is R1-1, R 2  is R2-1, R 3  is R3-1, R 4  is R4-1, R 5  is R5-1, R 6  is R6-2, R 7  is R7-1, R 8  is R8-2, R 9  is R9-2, R 10  is R10-1, R 11  is R11-1, R 12  is hydrogen, R 13  is R13-1, X is X1 and Y is Y2, and R 1  and R 2 , R 1  and R 4 , R 8  and R 9 , or R 13  and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted,   23) a compound wherein R 1  is R1-1, R 2  is R2-1, R 3  is R3-1, R 4  is R4-1, R 5  is R5-1, R 6  is R6-2, R7 is R7-1, R 8  is R8-2, R 9  is R9-1, R 10  is R10-1, R 11  is R11-1, R 12  and hydrogen, R 13  is R13-2, X is X1 and Y is Y2, and R 1  and R 2 , R 1  and R 4 , R 8  and R 9  or R 13  and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted,   24) a compound wherein R 1  is R1-2, R 2  is R2-1, R 3  is R3-1, R 4  is R4-1, R 5  is R5-1, R 6  is R6-2, R 7  is R7-1, R 8  is R8-2, R 9  is R9-2, R 10  is R10-1, R 11  is R11-1, R 12  is hydrogen, R 13  is R13-2, X is X1 and Y is Y1, and R 1  and R 2 , R 1  and R 4 , R 8  and R 9 , or R 13  and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted,   25) a compound wherein R 1  is R1-2, R 2  is R2-1, R 3  is R3-1, R 4  is R4-1, R 5  is R5-1, R 6  is R6-2, R 7  is R7-1, R 8  is R8-2, R 9  is R9-2, R 10  is R10-1, R 11  is R11-1, R 12  is hydrogen, R 13  is R13-1, X is X1 and Y is Y2, and R 1  and R 2 , R 1  and R 4 , R 8  and R 9 , or R 13  and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted,   26) a compound wherein R 1  is R1-2, R 2  is R2-1, R 3  is R3-1, R 4  is R4-1, R 5  is R5-1, R 6  is R6-2, R 7  is R7-1, R 8  is R8-2, R 9  is R9-1, R 10  is R10-1, R 11  is R11-1, R 12  is hydrogen, R 13  is R13-2, X is X1 and Y is Y2, and R 1  and R 2 , R 1  and R 4 , R8 and R 9 , or R 13  and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted,   27) a compound wherein R 1  is R1-1, R 2  is R2-1, R 3  is R3-1, R 4  is R4-1, R 5  is R5-1, R 6  is R6-2, R 7  is R7-1, R 8  is R8-2, R 9  is R9-2, R 10  is R10-1, R 11  is R11-1, R 12  is hydrogen, R 13  is R13-2, X is X1 and Y is Y2, and R 1  and R 2 , R 1  and R 4 , R 8  and R 9 , or R 13  and —X—Y taken together may form a 5- or 6-membered ring which contains one or more of O or NR 15  wherein R 15  is the same as defined above and which may optionally be substituted,   28) a compound wherein R 1  is R1-2, R 2  is R2-2, R 3  is R3-2, R 4  is R4-2, R 5  is R5-2, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-2, R 10  is R10-2, R 12  is hydrogen, R 13  is R13-2, X is X2 and Y is Y2, and R 1  and R 4 , or R 8  and R 9  taken together may form a 5- or 6-membered ring which contains one or more of O,   29) a compound wherein R 1  is R1-3, R 2  is R2-2, R 3  is R3-2, R 4  is R4-2, R 5  is R5-2, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-2, R 10  is R10-2, R 1  and R 4 , or R 8  and R 9  taken together may form a 5- or 6-membered ring which contains one or more of O,   30) a compound wherein R 1  is R1-4, R 2  is R2-2, R 3  is R3-2, R 4  is R4-2, R 5  is R5-2, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-2, R 10  is R10-2, R 11  is R11-2, R 12  is hydrogen, R 13  is R13-2, X is X2 and Y is Y2, and R 1  and R 4 , or R 8  and R 9  taken together may form —OCH 2 O—,   31) a compound wherein R 1  is R1-2, R 2  is R2-2, R 3  is R3-2, R 4  is R4-2, R 5  is R5-2, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-3, R 10  is R10-2, R 12  is hydrogen, R 13  is R13-2, X is X2 and Y is Y2, and R 1  and R 4 , or R 8  and R 9  taken together may form a 5- or 6-membered ring which contains one or more of O,   32) a compound wherein R1 is R1-2, R 2  is R2-2, R 3  is R3-2, R 4  is R4-2, R 5  is R5-2, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-4, R 10  is R10-2, R 11  is R11-2, R 12  is hydrogen, R 13  is R13-2, X is X2 and Y is Y2, and R 1  and R 4 , or R 8  and R 9  taken together may form a 5- or 6-membered ring which contains one or more of O,   33) a compound wherein R 1  is R1-2, R 2  is R2-2, R 3  is R3-2, R 4  is R4-2, R 5  is R5-2, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-2, R 10  is R11-2, R 12  is hydrogen, R 13  is R13-3, X is X2 and Y is Y2, and R 1  and R 4 , or R 8  and R 9  taken together may form a 5- or 6-membered ring which contains one or more of O,   34) a compound wherein R 1  is R1-2, R 2  is R2-2, R 3  is R3-2, R 4  is R4-2, R 5  is R5-2, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-2, R 10  is R10-2, R 11  is R11-2, R 12  is hydrogen, R 13  is R13-4, X is X2 and Y is Y2, and R 1  and R 4 , or R 8  and R 9  taken together may form a 5- or 6-membered ring which contains one or more of O,   35) a compound wherein R 1  is R1-2, R 2  is R2-2, R 3  is R3-2, R 4  is R4-2, R 5  is R5-2, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-2, R 10  is R10-2, R 11  us R11-2, R 12  is hydrogen, R 13  is R13-2, X is X2 and Y is Y3, and R 1  and R 4 , or R 8  and R 9  taken together may form a 5- or 6-membered ring which contains one or more of O,   36) a compound wherein R 1  is R1-3, R 2  is R2-2, R 3  is R3-2, R 4  is R4-2, R 5  is R5-2, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-3, R 10  is R10-2, R 11  is R11-2, R 12  is hydrogen, R 13  is R13-2, X is X2 and Y is Y2, and R 1  and R 4 , or R 8  and R 9  taken together may form a 5- or 6-membered ring which contains one or more of O,   37) a compound wherein R 1  is R1-3, R 2  is R2-2, R3 is R3-2, R 4  is R4-2, R 5  is R5-2, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-2, R 10  is R10-2, R 11  is R11-2, R 12  is hydrogen, R 13  is R13-3, X is X2 and Y is Y2, and R 1  and R 4 , or R 8  and R 9  taken together may form a 5- or 6-membered ring which contains one or more of O,   38) a compound wherein R 1  is R1-3, R 2  is R2-2, R 3  is R3-2, R 4  is R4-2, R 5  is R5-2, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-2, R 10  is R10-2, R 11  is R11-2, R 12  is hydrogen, R 13  is R13-2, X is X2 and Y is Y3, and R 1  and R 4 , or R 8  and R 9  taken together may form a 5- or 6-membered ring which contains one or more of O,   39) a compound wherein R 1  is R1-2, R 2  is R2-2, R 3  is R3-2, R 4  is R4-2, R 5  is R5-1, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-3, R 10  is R10-2, R 11  is R11-2, R 12  is hydrogen, R 13  is R13-3, X is X2 and Y is Y2, and R 1  and R 4 , or R 8  and R 9  taken together may form a 5- or 6-membered ring which contains one or more of O,   40) a compound wherein R 1  is R1-2, R 2  is R2-2, R 3  is R3-2, R 4  is R4-2, R 5  is R5-2, R 6  is R6-3, R 7  is R7-2, R 8  is R8-2, R 9  is R9-3, R 10  is R10-2, R 11  is R11-2, R 12  is hydrogen, R 13  is R13-2, X is X2 and Y is Y3, and R 1  and R 4 , or R 8  and R 9  taken together may form a 5- or 6-membered ring which contains one or more of O,   41) a compound wherein R 1  is R1-2, R 2  is R2-2, R 3  is R3-2, R 4  is R4-2, R 5  is R5-2, is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-2, R 10  is R10-2, R 11  is R11-2, R 12  is hydrogen, R 13  is R13-3, X is X2 and Y is Y3, and R 1  and R 4 , or R 8  and R 9  taken together may form a 5- or 6-membered ring which contains one or more of O,   42) a compound wherein R 1  is R1-3, R 2  is R2-2, R 3  is R3-2, R 4  is R4-2, R 5  is R5-2, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-3, R 10  is R10-2, R 11  is R10-2, R 12  is hydrogen, R 13  is R13-3, X is X2 and Y is Y2, and R 1  and R 4 , or R 8  and R 9  taken together may form —OCH 2 O—,   43) a compound wherein R 1  is R1-3, R 2  is R2-2, R 3  is R3-2, R 4  is R4-2, R 5  is R5-2, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-3, R 10  is R10-2, R 11  is R11-2, R 12  is hydrogen, R 13  is R13-2, X is X2 and Y is Y3, and R 1  and R 4 , or R 8  and R 9  taken together may form —OCH 2 O—,   44) a compound wherein R 1  is R1-3, R 2  is R2-2, R 3  is R3-3, R 4  is R4-2, R 5  is R5-2, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-2, R 10  is R10-2, is R 11  is R11 -2, R 12  is hydrogen, R 13  is R13-3, X is X2 and Y is Y3, and R 1  and R 4 , or R 8  and R 9  taken together may form —OCH 2 O—,   45) a compound wherein R 1  is R1-2, R 2  is R2-2, R 3  is R3-3, R 4  is R4-2, R 5  is R5-3, R 6  is R6-2, R 7  is R7-2, R 8  is R8-2, R 9  is R9-3, R 10  is R10-2, R 11  is R11-2, R 12  is hydrogen, R 13  is R13-3, X is X2 and Y is Y3, and R 1  and R 4 , or R 8  and R 9  taken together may form a 5- or 6-membered ring which contain one or more of O,   46) a compound wherein R 1  is R1-3, R 2  is R2-2, R 3  is R3-3, R 4  is R4-2, R 5  is R5-1, R 6  is R6-3, R 7  is R7-2, R 8  is R8-2, R 9  is R9-3, R 10  is R10-2, R 11  is R11-2, R 12  is hydrogen, R 13  is R13-3, X is X3 and Y is Y4, and R 1  and R 4 , or R 8  and R 9  taken together may form —OCH 2 O—,   47) a compound wherein R 1  is R1-4, R 2  is R2-2, R 3  is R3-3, R 4  is R4-2, R 5  is R5-3, R 6  is R6-3, R 7  is R7-2, R 8  is R8-2, R 9  is R9-4, R 10  is R10-2, R 11  is R11-2, R 12  is hydrogen, R 13  is R13-4, X is X3 and Y is Y4, RI and R 4  taken together may form —OCH 2 O— and R 8  and R 9  taken together may form —OCH 2 CH 2 O—,   48) a compound wherein the benzene ring which is substituted with R 1 –R 5  is   

     
       
         
         
             
             
         
       
         
         49) a compound wherein the benzene ring which is substituted with R 6 –R 9  is 
       
    
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
         
         50) a compound wherein the benzene ring which is substituted with R 10 –R 13  is 
       
    
     
       
         
         
             
             
         
       
         
         51) a compound wherein Y is —CH 2 CH═CMe 2 , —(CH 2 ) 2 CH═CMe 2 , —CH 2 CH═CCl 2 , —CH 2 CH═CBr 2 , —CH 2 CH═CF 2 , —CH 2 CH═CHMe, —CH 2 CH═C(Me)CH 2 OH, —CH 2 C≡CMe, —CH 2 C 6 H 4 -4-Me, —CH 2 C 6 H 5 , —CH 2 CH 2 CHMe 2  or —Me, 
         52) a compound wherein —X—Y is —OCH 2 CH═CMe 2 , —O(CH 2 ) 2 CH═CMe 2 , —OCH 2 CH═CCl 2 , —OCH 2 CH═CBr 2 , —OCH 2 CH═CF 2 , —OCH 2 C≡CMe, —OCH 2 C 6 H 4 -4-Me, —OCH 2 C 6 H 5 , —NHCH 2 CH═CMe 2 , —N(Me)CH 2 CH═CMe 2 , —NHCH 2 CH 2 CHMe 2 , —NHCH 2 C≡CH, or —NMe 2 , or 
         53) a compound wherein at least seven of the substituents of R 1 –R 13  are hydrogen, preferably at least eight are hydrogen, more preferably at least nine are hydrogen, and their pharmaceutically acceptable salts, their hydrates and their prodrugs. 
       
    
     A process for producing the compound (I′″) is as follows. 
     Process for Producing the Compound (I′″) [Process a] 
     The compound (I′″) can be produced by the reaction of a borane compound of the formula (II) and (II′) coupled with a biphenyl derivative of the formula (III) and (III′) respectively, as shown below. 
                         
wherein R 1 –R 13 , X and Y are the same as defined in the above formula (I′″), and A and Z are the same as defined in the above formulas (II) and (III), or
 
                         
wherein R 1 –R 13 , X and Y are the same as defined in the above formula (I′″), and A and Z are the same as defined in the above formulas (II) and (III).
 
     The compounds (II) and (II′) are reacted with the compounds (III) and (III′) respectively in a mixture system of an appropriate solvent such as benzene, toluene, dimethylformamide, dimethoxyethane, tetrahydrofuran, dioxane, ethanol, methanol or the like and water or in an anhydrous system in the presence of a palladium catalyst such as Pd(PPh 3 ) 4 , PdCl 2 (PPh 3 ) 2 , PdCl 2 (OAc) 2 , PdCl 2 (CH 3 CN) 2  or the like, Pd(PPh 3 ) 4 , under a basic condition (for example, by K 3 PO 4 , NaHCO 3 , NaOEt, Na 2 CO 3 , Et 4 NCl, Ba(OH) 2 , Cs 2 CO 3 , CsF, NaOH, Ag 2 CO 3  or the like) at room temperature or with heating for several tens minutes to several tens hours to obtain the compound (I′″). 
     One of substituents A and Z of the compounds to be reacted may be any of the borane groups which are applicable in the Suzuki Reaction (Chemical Communication 1979, 866, Journal of Synthetic Organic Chemistry, Japan, 1993, Vol. 51, No. 11, 91–100) and dihydroxyborane is preferable. The other may be any of the leaving groups which are applicable in the Suzuki Reaction, for example, halogen, —OSO 2 (C q F 2q+1 ) wherein q is an integer of 0 to 4, or the like. Specifically, halogen, trifluoromethanesulfonyloxy (hereinafter referred to as OTf) or the like is preferable and bromine, iodine or OTf is more preferable. 
     The substituents R 1 –R 13  and —X—Y of the compounds (II), (III), (II′) and (III′) may be any of the groups which do not affect the Suzuki Reaction, for example, any groups other than halogen and —OSO 2 (C q F 2q+ 1) wherein q is an integer of 0 to 4. 
     For example, Y may be optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl, Y may be optionally substituted lower alkoxy when X is —CH 2 — and Y may be optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is —O— or —NR14—. Even if R 1 –R 13  or Y is halogen, these reactions can be carried out without difficulty when the reactivity of the substituent A with the substituent Z is higher than that of halogen with either of substituents A and Z. 
     Even if one of R 1 –R 13  and —X—Y is hydroxy, the above reactions can be carried out preferably after the protection of hydroxy group with a usual hydroxy-protecting group (for example, metoxymethyl, benzyl, tert-butyldimethylsilyl, methansulfonyl, p-toluenesulfonyl or the like), followed by the removal of them by usual methods. 
     As processes for producing the compound (I′″), the above mentioned Suzuki Reaction is most preferable in view of the efficiency and easiness but silicon, zinc, tin or the like can be used in place of the borane group in the above scheme. 
     For example, in the case that one of A and Z is —SiR 17   3-r (Hal) r  wherein R 17  is independently lower alkyl, Hal is halogen and r is an integer of 1 to 3 and the other is halogen or —OSO 2 (C q F 2q+1 ) wherein q is an integer of 0 to 4, the coupling reaction may be carried out using a usual palladium catalyst (Synlett (1991) 845–853, J. Org. Chem. 1996, 61, 7232–7233). Examples of preferable palladium catalysts are (i-Pr 3 P) 2 PdCl 2 , [(dcpe)PdCl 2 ](dcpe=Cy 2 PCH 2 CH 2 PCy 2 ), (η 3 —C 3 H 5 PdCl) 2  and the like. 
     Even in the case that one of A and Z is —SnR 18   3  wherein R 18  is each independently lower alkyl and the other is halogen, acetyloxy or —OSO 2 (C q F 2q+1 ) wherein q is an integer of 0 to 4, an objective compound can be obtained using a usual palladium catalyst (preferably Pd(PPh 3 ) 4  or the like) (Angew. Chem. Int. Ed. Engl. 25 (1986) 508–524). 
     In the case that one of A and Z is —Zn(Hal) wherein Hal is halogen and the other is halogen, an objective compound can be obtained (Acc. Chem. Res. 1982, 15, 340–348). Any usual palladium catalyst is applicable and Pd(PPh 3 ) 4 , PdCl 2 (dppf), PdCl 2 (PPh 3 ) 2 , PdCl 2 (P(o-Tolyl) 3 ) 2 , Pd(OAc) 2  and the like are exemplified as preferable examples. 
     All of these reactions may be carried out in a suitable solvent (for example, dimethylformamide, tetrahydrofuran or the like) at room temperature or with heating for several tens minutes to several tens hours. 
     Process for Producing the Compound (I′″) [Process b] 
     As another easier processes for producing the compound (I′″), the following process wherein the compound of the formulas (IV), (V) and (VI) are coupled is also applicable. 
                         
wherein R 1 –R 13 , X and Y are the same as defined in the above formulas (I), (II) and (III) and A 1 , A 2 , Z 1  and Z 2  are the same as defined in the above A and Z, respectively. The reactivity of A 1  is higher than or equal to that of A 2  in the compound (IV) and the reactivity of A 2  is higher than or equal to that of A 1  in the compound (IV′).
 
     For production of the compound (I′″) by the above process the compound (IV) may be reacted with the compound (V), followed by the reaction with the compound (VI) without an isolation. The objective compound can be obtained also by a process wherein the compound (IV′) is reacted with the compound (VI), followed by a reaction with the compound (V). 
     Because the reactions of the substituents A 1  and Z 1  and the substituents A 2  and Z 2  are necessary to obtain the objective compound, the reactivity of the substituent A 1  and that of A 2  should be different. A preferable example is the combination that A 1  is iodine and A 2  is bromine or OTf in the compound (IV). Conversely in the compound (IV′) iodine for A 2  and bromine or OTf for A 1  are preferable. In the case that the compound (IV) or (IV′) is a symmetry compound, the objective compound is obtained even if A 1  and A 2  are the same group. 
     The substituents Z 1  and Z 2  may be the same or different group. 
     Various other conditions in this process are the same as those in the “Process a”. 
     In the above compounds, the substituents R 1 –R 13  may be any of the groups which do not affect the reaction (for example, a group other than halogen and —OSO 2 (C q F 2q+1 ) wherein q is an integer of 0 to 4) or any of the groups which do not affect the reaction and are changeable to R 1 –R 13  by a usual reaction. In the latter case the substituents may be changed to R 1 –R 13  in suitable steps according to the reaction of each compound. 
     For example, in the case that a substituent is formyl and an objective substituent is hydroxy, after the substituent is changed to formyloxy by the Baeyer-Villiger reaction etc., a usual hydrolysis reaction may be carried out under an acidic or alkaline condition. Specifically, a compound which has formyl is reacted with a peroxy acid such as peracetic acid, perbenzoic acid, m-chloroperbenzoic acid, trifluoroperacetic acid, hydrogen peroxide or the like in a suitable solvent such as 1,2-dichloroethane, chloroform, dichloromethane, carbon tetrachloride, benzene or the like at −20° C. or with heating for several minutes to several tens hours, followed by the hydrolysis of the obtained compound which has formyloxy under an acidic condition (for example, with heating with hydrochloric acid) or under a basic condition (for example, with heating with sodium hydroxide). 
     In the case that a substituent is formyl and an objective substituent is hydroxymethyl, the compound which has formyl may be reacted with a reductant such as sodium borohydride, lithium borohydride, zinc borohydride, triethyllithium borohydride, alminium hydride, diisobutylalminium hydride or the like in a solvent (for example, methanol, ethanol, isopropanol, dimethylsulfoxide, diethylene glycol dimethoxyethane, tetrahydrofuran, benzene, toluene, cyclohexane or the like) which is suitable for the reductant at −20° C. to 80° C., preferably under ice-cooling or at room temperature, for several tens minutes to several hours. 
     In the case that a substituent is formyl and an objective substituent is alkenyl having additional carbon atoms, an objective compound can be obtained by the Wittig Reaction (Organic Reaction, 1965, vol. 14, p. 270). 
     In the case that a substituent is formyl and an objective substituent is carboxy, the compound which has formyl may be reacted with an oxidizing agent such as sodium chlorite, the Jones Reagent, chromic anhydride or the like in a solvent such as tert-butanol, acetone or the like which is suitable for the oxidizing agent at 0° C. or with heating for several hours. The reaction is preferably carried out by addition of 2-methyl-2-buten, sodium dihydrogenphosphate or the like if needed. 
     In the case that a substituent is hydroxy and an objective substituent is substituted lower alkoxy, the compound which has hydroxy may be reacted with a proper alkylating agent in the presence of a base such as sodium carbonate, sodium bicarbonate, potassium carbonate, calcium hydroxide, barium hydroxide, calcium carbonate or the like in a suitable solvent such as tetrahydrofuran, acetone, dimethylformamide, acetonitrile or the like. Specifically, the reaction of a compound which has hydroxy with a proper halogenated compound such as methyl iodoacetate, ethyl chloroacetate, propyl chloroacetate or the like can give a compound of which substituent is alkoxycarbonyl(lower)alkoxy. 
     In the case that a substituent is carboxy and an objective substituent is carbamoyl, the compound which has carboxy may be carbamoylated with an amine such as ammonia, dimethylamine or the like at 0° C. or with heating for several minutes to several hours in a suitable solvent such as tetrahydrofuran, dimethylformamide, diethyl ether, dichloromethane or the like, if necessary after activation by an activating agent such as thionyl chloride, an acid halide, an acid anhydride, an activated ester or the like. 
     In the case that a substituent is hydrogen and an objective substituent is halogen, the compound which has hydrogen may be halogenated by a halogenating agent which is generally used (for example, bromine, chlorine, iodine, sulfuryl chloride, N-bromosuccinimide, N-iodosuccinimide or the like) in a suitable solvent such as chloroform, dichloromethane, carbon tetrachloride, acetonitrile, nitromethane, acetic acid, acetic anhydride or the like, if necessary in the presence of a catalyst such as the Lewis acid, hydrochloric acid, phosphoric acid or the like at −20° C. or with heating for several minutes to several tens hours. 
     The compound (I) can be obtained by a reaction of the compound (II) which has a substituent —X—Y with the compound (III) or a reaction of the compound (III′) which has a substituent —X—Y with the compound (II′). Further, the compound (I) can also be obtained by a reaction of the compound (II) or (III′) which has a substituent —W which is convertible into a substituent —X—Y with the compound (III) or (II′), followed by a conversion of a substituent —W into a substituent —X—Y. 
     For example, in the case of a compound wherein —W is hydroxy or protected hydroxy, an objective substituent such as lower alkyl, lower alkenyl, lower alkynyl, acyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, lower alkoxy or the like may be introduced by a usual reaction. 
     Concretely, to obtain a compound wherein X is —O—, a compound wherein —W is hydroxy is synthesized and dissolved in a suitable solvent (for example, dimethylformamide, tetrahydrofuran, acetone, benzene, dioxane, acetonitrile or the like), followed by addition of a base such as hydroxides or carbonates of alkaline metals or alkaline-earth metals (for example, sodium carbonate, sodium bicarbonate, potassium carbonate, calcium hydroxide, barium hydroxide, calcium carbonate and the like) or tertiary amines such as triethylamine and the like. To the reactant is added a compound Y—V wherein V is halogen or —OSO 2 (C q F 2q+1 ) wherein q is an integer of 0–4 (for example, prenyl bromide, cyclohexenyl bromide, cinnamyl bromide, 1-bromo-2-penten, geranyl bromide, 5-bromo-2-methyl-2-penten, 1,3-dichloro-2-buten, 3-chloropropyne, prenyl triflate, cyclohexenyl triflate, 1,3-trichloropropene or the like) at −20° C. or with heating for several minutes to several tens hours to obtain an objective compound wherein —W has been converted into —O—Y. 
     To obtain a compound wherein X is —CH 2 —, —N R 14 — or —S—, a compound wherein —W is hydroxy is reacted with trifluoromethanesulfonic anhydride etc. in a solvent such as anhydrous dichloromethane, chloroform, carbon tetrachloride or the like in the presence of a base such as pyridine, triethylamine or the like to obtain a triflate. Then, the obtained compound is reacted with Y—V′ wherein V′ is —CH 2 ZnI, —SH, —NHR 14  in the presence of a catalyst such as palladium, nickel or the like in a suitable solvent such as tetrahydrofuran, dimethylformamide, diethyl ether, dimethoxyethane or the like to give an objective compound. 
     In the case that X is NR 14 , a compound wherein W is NH 2  may be reacted with a ketone or an aldehyde in a suitable solvent such as tetrahydrofuran, methanol or the like, followed by reduction with a suitable reductant such as sodium borohydride, sodium cyanoborohydride, zinc hydrochloride or the like or by catalytic reduction to obtain an objective compound. 
     A usual reaction of a compound wherein W is NH 2  with Y—V″ wherein Y is acyl, lower alkylsulfonyl optionally substituted or arylsulfonyl optionally substituted and V″ is a leaving group such as halogen gives a compound wherein —X—Y is —NH—Y. 
     To obtain a compound wherein X is —SO— or —SO 2 —, a compound wherein X is —S— which is synthesized by the above mentioned process may be oxidized with a usual oxidizing agent such as m-chloroperbenzoic acid. 
     A compound of the present invention wherein —X—Y is lower alkenyloxy is dissolved in a solvent such as ethanol, ethyl acetate or the like and hydrogenated with a catalyst such as Pd-carbon powder, platinum, rhodium, ruthenium, nickel or the like to give a compound wherein —X—Y is lower alkoxy. 
     A reaction of a compound wherein —X—Y is lower alkenyloxy with m-chloroperbenzoic acid or the like in a solvent such as dichloromethane, chloroform, benzene, hexane, tert-butanol or the like gives a compound wherein —X—Y is epoxidated lower alkoxy. 
     In the case that a compound has a substituent interfering of a reaction, the substituent may be protected with a suitable protecting group in advance and the protecting group may be left in a suitable step by a usual method. For example, if hydroxy interferes the reaction, hydroxy may be protected with methoxymethyl, methanesulfonyl, benzyl, trifluoromethanesulfonyl, tert-butyldimethylsilyl or the like, followed by deprotection in a suitable step. 
     For example, for a protection of hydroxy with methanesulfonyl, a compound which has hydroxy may be reacted with methanesulfonyl chloride in a solvent such as dichloromethane, chloroform, carbon tetrachloride or the like in the presence of a base such as triethylamine, pyridine or the like under ice-cooling or at room temperature for several hours. The protected compound may be deprotected with 1–4 N sodium hydroxide, potassium hydroxide, aqueous solution thereof, sodium methoxide, ethyl magnesium bromide or the like in a solvent such as dimethylsulfoxide, dimethylformamide, tetrahydrofuran, dioxane, dimethoxyethane or the like at room temperature or with heating for several tens minutes to several hours. 
     When methoxymethyl is used as a protecting group of hydroxy, a compound which has hydroxy may be reacted with chloromethylmethylether in a solvent such as tetrahydrofuran, dioxane, dimethoxyethane or the like in the presence of sodium hydride, diisopropylethylamine or the like to obtain a compound which has a protected hydroxy group. The compound may be subjected to a usual deprotection reaction with hydrochloric acid, sulfuric acid or the like in a solvent such as methanol, tetrahydrofuran, acetic acid or the like for a deprotection. 
     When tert-butyldimethylsilyl is used as a protective group, a compound which has hydroxy may be reacted with tert-butyldimethylsilyl chloride, tert-butyldimethylsilyl triflate or the like in a solvent such as dimethylformamide, acetonitrile, tetrahydrofuran, dimethylformamide, dichloromethane or the like in the presence of imidazole, triethylamine, 2,6-lutidine or the like. For a deprotection reaction the protected compound may be reacted with tetrabutylammonium fluoride or the like in a solvent such as tetrahydrofuran or the like. 
     Both of known compounds and the compounds which are produced by the following process may be used as the compounds (III) and (III′) in the above scheme. 
     
       
         
         
             
             
         
       
     
     Known compounds (VIII) and (IX), or (VIII′) and (IX′) wherein A and Z are groups which can be subjected to a coupling reaction by the Suzuki Reaction with each other; for example, one is borane such as dihydroxyborane, di(lower)alkoxyborane or the like and the other is halogen or —OSO 2 (C q F 2q+1 ) wherein q is an integer of 0–4; D is a group other than halogen and —OSO 2 (C q F 2q+1 ) wherein q is the same as defined above are reacted by the same method as above to obtain a compound (VII) or (VII′). 
     As described above, instead of a compound which has borane, a compound which has —SiR 17   3-r (Hal) r  wherein R 17  is each independently lower alkyl, Hal is halogen and r is an integer of 1–3, —SnR 18   3  wherein R 18  is each independently lower alkyl or —Zn(Hal) wherein Hal is halogen may be used for a reaction to obtain an objective compound. 
     Then, a substituent D is converted into a substituent A which is applicable to the Suzuki Reaction. 
     For example, a compound wherein D is hydrogen may be reacted with a halogenating agent such as bromine, chlorine, iodine, sulfuryl chloride, N-bromosuccinimide or the like in a suitable solvent such as acetic acid, chloroform, dichloromethane, carbon tetrachloride, water, acetic acid-sodium acetate or the like at −20° C. or with heating for several minutes to several tens hours to give an objective compound wherein A is halogen. 
     A compound wherein D is protected hydroxy may be reacted with a trifluoromethanesulfonating agent such as trifluoromethanesulfonic anhydride, trifluoromethansulfonyl chloride or the like in a suitable solvent such as dichloromethane, chloroform, tetrahydrofuran or benzene in the presence of a base such as pyridine or triethylamine at −20° C. or with heating for several minutes to several tens hours to give an objective compound wherein A is OTf. 
     A compound of the present invention thus obtained can be converted into prodrug thereof. Any usual methods for conversion into a prodrug may be used. For example, hydroxy or amino which is attached a compound of the present invention at any position may be substituted with a usual group for a prodrug. An example of conversion into a prodrug is a substitution of hydroxy with acyloxy substituted with carboxy, sulfo, amino, lower alkylamino or the like, phosphonoxy etc. A substitution of hydroxy for R 1  with —OCOCH 2 CH 2 COOH, —OCOCH═CHCOOH, —OCOCH 2 SO 3 H, —OPO 3 H 2 , —OCOCH 2 NMe 2 , —OCO-Pyr wherein Pyr is pyridine or the like is preferable. 
     A selective suppressor of the IgE production of the present invention comprises a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which does not suppress or weakly suppresses the production of the immunoglobulins IgG, IgM and/or IgA which are produced at the same time. 
     The term “suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody” means to suppress the IgE production by inhibiting one of the following processes.
     1) A process wherein mature B cells are activated by various factors such as cytokines, i.e., IL-4, IL-5, etc., anti-CD40 antibody or the like,   2) A process wherein the activated B cells differentiate into antibody-producing cells such as plasma cells etc. (concretely, a process of switching of the activated B cells to IgE class antibody-producing cells) and/or   3) A process wherein the antibody-producing cells produce immunoglobulins (specifically, a process of the IgE production)   

     An inhibition of “a process wherein a mature B cell is activated by various factors” in the process 1) does not include an inhibition of a process wherein the factors are produced from other cells and the like. 
     The term “suppresses the IgE production and does not suppress or weakly suppresses the production of the immunoglobulins IgG, IgM and/or IgA which are produced at the same time” means that the IgE production is suppressed enough to suppress allergy reactions and that the IgG, IgM and/or IgA production is not suppressed so potent as to badly affect an immune system concerning a living body protection under the condition that IgE and one or more of IgG, IgM and IgA can be produced at the same time. In other words,
     {circle around (0)} The suppression of the IgE production is 5,000 times, preferably 10,000 times, more preferably 15,000 times, most preferably 20,000 times or more as potent as those of the IgG, IgM and/or IgA production and/or   {circle around (2)} The IgG, IgM and/or IgA production is not suppressed to less than 50% even at 5,000 times, preferably 10,000 times, more preferably 15,000 times, most preferably 20,000 times the concentration at which 50% of the IgE production is suppressed as compared with that in the absence of the suppressor.   

     The term “the concentration at which 50% of the IgE production is suppressed as compared with that in the absence of the suppressor” means a concentration at which the IgE production is limited to 50% of the production in the absence or without administration of the selective suppressor of the IgE production of the present invention under the condition that the IgE can be produced. The suppressor is useful as a medicament when it has a selectivity for the IgE as compared with at least one of IgG, IgM or IgA, preferably with all of them. 
     The selective suppressor of the IgE production of the present invention suppresses 90% or more of the IgE production as compared with that without administration of the suppressor at a dosage that the suppressor does not suppress or weakly suppresses the IgM, IgG and/or IgA production when the suppressor is administered to a mammal, which includes human, sensitized by an allergen. The term “allergen” means any substance that can induce the IgE production and an allergic reaction. Clinical examples are pollen, a acarid, house dust, albumin, milk, a soybean etc. and experimental examples are ovalbumin, bovine gamma globulin, bovine serum albumin, an antigen protein of cedar pollen (Cryj I and Cryj II), an antigen protein for acarid (Derf I and Derf II) etc. The term “a dosage that the suppressor does not suppress or weakly suppresses the IgM, IgG and/or IgA production” means the dosage at which the suppression rate of the IgG, IgM and/or IgA is 10% or less, preferably 5% or less, more preferably 3% or less as compared with those produced without administration of the selective suppressor of the IgE production of the present invention. 
     The selective suppressor of the IgE production of the present invention suppresses infiltration of an inflammatory cell to a tissue. The term “inflammatory cell” includes all of a lymphocyte, an eosinophil, a neutrophile and a macrophage, and an eosinophil and/or a neutrophile are preferable. 
     The effect of the selective suppressor on the IgE production of the present invention is potent for its direct action to B cells. Because the suppressor does not affect the humoral immunity concerning a biological protective reaction, it has many advantages, for example, little side effect such as infections etc., 
     All of compounds that have the above effect are useful as an immunosuppressor regardless of the structure and one of the examples is the compound (I) or (I″) of the present invention. 
     The compounds of the present invention also include ones which have the suppressive effect on a mitogen reaction and/or a cytokine reaction. 
     Specifically, the compounds have a potent antiproliferative effect on T and/or B cells and/or a suppressive effect on the IL-5 and/or IL-4 production. They selectively suppress the IL-4 and/or IL-5 production and do not suppress the IL-2 production. 
     The immunosuppressor or anti-allergic agent of the present invention is useful for prevention or a treatment of allergic diseases such as a rejection symptom against a transplantation of an organ or a tissue, a graft-versus-host reaction which is caused by a bone marrow transplantation, atopic allergic diseases (for example, a bronchial asthma, an allergic rhinitis, an allergic dermatitis and the like), a hypereosinophils syndrome, an allergic conjunctivitis, a systemic lupus erythematosus, a polymyositis, a dermatomyositis, a scleriasis, MCTD, a chronic rheumatoid arthritis, an inflammatory bowel disease, an injury caused by ischemia-reperfusion, a pollenosis, an allergic rhinitis, an urticaria, a psoriasis and the like. 
     When the compound of the present invention is administered as a immunosuppressor and/or anti-allergic agent, it can safely be administered both orally and parenterally. In the case of an oral administration, it may be in any usual forms such as tablets, granules, powders, capsules, pills, solutions, suspensions, syrups, buccal tablets, sublingual tablets and the like for the administration. When the compound is parenterally administered, any usual forms are preferable, for example, injections such as intravenous injections and intramuscular injections, suppositories, endermic agents, vapors and the like. An oral administration is particularly preferable. 
     A pharmaceutical composition may be manufactured by mixing an effective amount of the compound of the present invention with various pharmaceutical ingredients suitable for the administration form, such as excipients, binders, moistening agents, disintegrators, lubricants, diluents and the like. When the composition is of an injection, an active ingredient can be sterilized with a suitable carrier to give a pharmaceutical composition. 
     Specifically, examples of the excipients include lactose, saccharose, glucose, starch, calcium carbonate, crystalline cellulose and the like, examples of the binders include methylcellulose, carboxymethylcellulose, hydroxypropylcellulose, gelatin, polyvinylpyrrolidone and the like, examples of the disintegrators include carboxymethylcellulose, sodium carboxymethylcellulose, starch, sodium alginate, agar, sodium lauryl sulfate and the like, and examples of the lubricants include talc, magnesium stearate, macrogol and the like. Cacao oil, macrogol, methyl cellulose and the like may be used as base materials of suppositories. When the composition is manufactured as solutions, emulsified injections or suspended injections, dissolving accelerators, suspending agents, emulsifiers, stabilizers, preservatives, isotonic agents and the like may be added. For an oral administration, sweetening agents, flavors and the like may be added. 
     Although a dosage of the compound of the present invention as an immunosuppressor and/or anti-allergic agent should be determined in consideration of the patient&#39;s age and body weight, the type and degree of diseases, the administration route or the like, a usual oral dosage for human adults is 0.05–100 mg/kg/day and the preferable dosage is 0.1–10 mg/kg/day. In the case that it is parenterally administered, although the dosage highly varies with administration routes, a usual dosage is 0.005–10 mg/kg/day, preferably, 0.01–1 mg/kg/day. The dosage may be administered in one or some separate administrations. 
     The present invention is further explained by the following Examples and Experiments, which are not intended to limit the scope of the present invention. 
     EXAMPLE 
     The abbreviations which are used in EXAMPLE mean the following. 
     
       
         
           
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Bn 
                 benzyl 
               
               
                   
                 DME 
                 1,2-dimethoxyethane 
               
               
                   
                 DMF 
                 N,N-dimethylformamide 
               
               
                   
                 DMSO 
                 dimethylsulfoxide 
               
               
                   
                 MCPBA 
                 m-chloroperbenzoic acid 
               
               
                   
                 MOM 
                 methoxymethyl 
               
               
                   
                 Ms 
                 methanesulfonyl 
               
               
                   
                 Py 
                 pyridyl 
               
               
                   
                 TBS 
                 tert-butyldimethylsilyl 
               
               
                   
                 Tf 
                 trifluoromethanesulfonyl 
               
               
                   
                 Ts 
                 p-toluenesulfonyl 
               
               
                   
                   
               
            
           
         
       
     
     Example 1 
     Synthesis of the Compounds (I-1), (I-2) and (I-3) 
                         
(Step 1) Synthesis of the Compound 1
 
     To 300 ml of a solution of 10.63 g (22.08 mmol) of a compound (III-1) in 1,2-dimethoxyethane was added 3.60 g (3.12 mmol) of tetrakis(triphenylphosphine)palladium (0) at room temperature. To the mixture were added 80 ml of a solution of a compound 2 (9.50 g; 26.5 mmol) in 99% ethanol and 125 ml (250 mmol) of an aqueous solution of 2 M sodium carbonate and the reacted suspension was heated under refluxing in an argon atmosphere for 6 hours. After cooling, the reaction mixture was filtered off to remove an insoluble material and the filtrate was acidified with 2 N hydrochloric acid and extracted with ethyl acetate. The extract was washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. After the residue was purified by silica gel chromatography (hexane-ethyl acetate 1:1), the obtained product was recrystallized from hexane-ethyl acetate to give the compound 1 (11.57 g; 87% yield) as colorless crystals. 
     (Step 2) Synthesis of the Compound (I-2) 
     To 60 ml of a suspension of the compound 1 (9.30 g; 15.48 mmol) in anhydrous dichloromethane was added 3.24 ml (23.22 mmol) of triethylamine, followed by addition of 1.80 ml (23.22 mmol) of methanesulfonyl chloride under ice-cooling and stirred for 2 hours at the same temperature. After the solvent was removed, the residue was acidified with 80 ml of 1 N hydrochloric acid and extracted with chloroform. The extract was washed with 1 N hydrochloric acid, 5% aqueous solution of sodium bicarbonate and saturated brine successively, and the obtained product was dried and concentrated. The obtained residue was recrystallized from hexane-ethyl acetate to give 9.93 g of the compound (I-2) (95% yield) as colorless crystals. 
     (Step 3) Synthesis of the Compound 3 
     Stirred were 300 ml of a solution of 9.76 g (14.38 mmol) of the compound (I-2) and 765 mg (4.31 mmol) of palladium chloride (II) in 1,4-dioxane under a hydrogen atmosphere at room temperature for 15 hours. An insoluble material was removed off by filtration with celite and the obtained filtrate was concentrated. The residue was recrystallized from hexane-ethyl acetate to give the compound 3 (8.43 g; 100% yield) as colorless crystals. 
     (Step 4) Synthesis of the Compound (I-3) 
     To 40 ml of a solution of the compound 3 (4.01 g; 6.81 mmol) in anhydrous N,N-dimethylformamide were added successive, 1.45 g (10.5 mmol) of potassium carbonate and 1.21 ml (10.5 mmol) of prenyl bromide. After the mixture was stirred under a nitrogen atmosphere for 15 hours at room temperature, the reaction mixture was poured into 230 ml of 6% aqueous citric acid and extracted with ethyl acetate. The extract was washed with 5% citric acid, 5% aqueous solution of sodium bicarbonate and saturated brine successively, followed by being dried and concentrated. The residue was recrystallized from hexane-ethyl acetate to give 4.01 g of the compound (I-3) (90% yield) as colorless crystals. 
     (Step 5) Synthesis of the Compound (I-1) 
     To 38 ml of a solution of 3.80 g (5.79 mmol) of the compound (I-3) in dimethylsulfoxide was added 15 ml (60.0 mmol) of 4 N sodium hydroxide and the reaction mixture was warmed at 60° C. for 4 hours. After the mixture was cooled, 100 ml of 1 N hydrochloric acid was added to it and the obtained mixture was extracted with ethyl acetate. The extract was washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was recrystallized from methanol to give 1.72 g of the compound (I-1) (70% yield) as colorless crystals. 
     Reference Example 1 
     Synthesis of the Compound 2 
     
       
         
         
             
             
         
       
     
     To a solution of the compound 4 (80.0 g; 0.287 mol) in 300 ml of N,N-dimethylformamide were added tert-butyldimethylsilyl chloride (45.87 g; 0.296 mol) and imidazole (21.46 g; 0.315 mol) and stirred at room temperature for 19 hours. The reaction mixture was poured into 1 L of water and extracted with ether. The extract was washed with water and saturated brine successively and then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 50:1) to give the compound 5 (97.20 g; 86% yield) as a colorless oil. 
     To 850 ml of a solution of the compound 5 (97.20 g; 0.247 mol) in annydrous tetrahydrofuran was added 152 ml (0.252 mol) of a solution of 1.66 N n-butyllithium in hexane under a nitrogen atmosphere at −70° C. and stirred at the same temperature for 1.5 hours. To the mixture was added 171 ml (0.741 mol) of triisopropyl borate at −70° C. and stirred for 3 hours with gradually warming to room temperature. Under cooling with ice, 500 ml of water and 320 ml of 5% citric acid were added to the mixture and stirred at the same temperature for 30 minutes. The solution was extracted with ethyl acetate and the extract was washed with water and saturated brine successively, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 2:1) to give the compound 2 (51.10 g; 58% yield) as colorless crystals. 
     Reference Example 2 
     Synthesis of the Compound (III-1) 
                         
(Step 1) Synthesis of the Compound 8
 
     To a solution of 15.30 g (62.4 mmol) of a compound 7 (Journal of Chemical Society, 1925, 1998) in 300 ml of 1,2-dimethoxyethane was added 3.60 g (3.12 mmol) of tetrakis(triphenylphosphine)palladium (0) at room temperature. To the mixture were added a solution of 18.89 g (74.9 mmol) of a compound 6 (GB-A No. 2276162) in 80 ml of 99% ethanol and 125 ml (250 mmol) of an aqueous solution of 2 M sodium carbonate and the reaction suspension was heated under refluxing in an argon atmosphere for 6 hours. After cooling, the reaction mixture was filtered off to remove an insoluble substance. The filtrate was acidified with 2 N hydrochloric acid and extracted with ethyl acetate. The extract was washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethylacetate 1:1) and recrystallized from hexane-ethyl acetate to give the compound 8 (15.68 g; 97% yield) as colorless crystals. 
     (Step 2) Synthesis of the Compound 9 
     To a suspension of the compound 8 (15.34 g; 59.39 mmol) in 240 ml of anhydrous dichloromethane were added 16.6 ml (118.8 mmol) of triethylamine and 6.93 ml (89.09 mmol) of methanesulfonyl chloride under ice-cooling and stirred at the same temperature for 2 hours. After the solvent was removed, the residue was acidified with 1 N hydrochloric acid (100 ml) and extracted with ethyl acetate. The extract was washed with 1 N hydrochloric acid, 5% aqueous solution of sodium bicarbonate and, saturated brine successively, then dried and concentrated. The residue was recrystallized from hexane-ethyl acetate to give the compound 9 (17.24 g; 86% yield) as colorless crystals. 
     (Step 3) Synthesis of the Compound (III-24) 
     To 210 ml of a suspension of the compound 9 (17.03 g; 50.63 mmol) in acetic acid were added 6.23 g (75.95 mmol) of sodium acetate and 3.91 ml (75.95 mmol) of bromine at room temperature and stirred at the same temperature for 16 hours. After 3.91 ml (75.95 mmol) of bromine was added to the reacted suspension and stirred at 50° C. for 4 hours, 3.91 ml (75.95 mmol) of bromine was added and stirred at 50° C. for 3 hours. The reaction mixture was poured into 1 L of 1 M aqueous sodium thiosulfate and stirred for 30 minutes. The precipitate was collected by filtration and washed with water. The obtained crystals were dissolved in 800 ml of chloroform, washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was recrystallized from hexane-ethyl acetate to give the compound (III-24) (18.12 g; 86% yield) as colorless crystals. 
     (Step 4) Synthesis of the Compound 10 
     To a suspension of the compound (III-24) (15.80 g; 38.05 mmol) in 400 ml of 1,2-dichloroethane was added 12.30 g (57.05 mmol) of 80% m-chloroperoxybenzoic acid at room temperature and stirred at the same temperature for 17 hours. The reaction mixture was poured into 360 ml of 0.2 M aqueous sodium thiosulfate and extracted with chloroform. The extract was washed with 300 ml of 0.2 M sodium thiosulfate and 200 ml of 5% of sodium bicarbonate (×2) successively, then dried and concentrated. The residue (15.80 g) was dissolved in 330 ml of 1,2-dimethoxyethane and 30 ml (120 mmol) of 4 N hydrochloric acid was added. After the reaction mixture was stirred at 50° C. for 12 hours and cooled, the solvent was removed and the residue was extracted with ethyl acetate. The extract was washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated to give the compound 10 (14.35 g; 97% yield) as pale brown crystals. 
     (Step 5) Synthesis of the Compound (III-1) 
     Using an analogous procedure for the compound (I-4), 12.63 g of the compound (III-1) as colorless crystals (88% yield) was obtained from the compound 10 (12.0 g; 29.76 mmol). 
     Example 2 
     Synthesis of the Compound (I-4) 
                         
(Step 1) Synthesis of the Compound 11
 
     To a solution of 816 mg (2 mmol) of a compound (III-2) in 40 ml of 1,4-dioxane were added 114 mg (0.1 mmol) of tetrakis(triphenylphosphine)palladium (0), 748 mg (2.09 mmol) of the compound 2 and 589 mg (2.77 mmol) of powders of anhydrous potassium phosphate at room temperature and heated in a nitrogen atmosphere at 85° C. for 23 hours. The reaction mixture was cooled and extracted with ethyl acetate. The extract was washed with 2 N hydrochloric acid, 5% aqueous sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 4:1) and crystallized from pentane to give the compound 11 (745 mg; 67% yield) as pale yellow crystals. 
     (Step 2) Synthesis of the Compound (I-4) 
     To a solution of the compound 11 (557 mg; 1 mmol) in 10 ml of dichloromethane was added 259 mg (1.2 mmol) of 80% m-chloroperbenzoic acid at room temperature and stirred for 15 hours. The reaction mixture was poured into 0.1 M aqueous sodium thiosulfate and extracted with ethyl acetate. The extract was washed with 0.1 M aqueous sodium thiosulfate, 5% aqueous sodium bicarbonate and saturated brine successively, then dried and concentrated. To a solution of 650 mg of the obtained residue in 5 ml of methanol was added a solution of 1 M sodium methoxide in 2 ml of methanol under ice-cooling and stirred for 30 minutes. After the reacted solution was acidified with 2 N hydrochloric acid and extracted with ethyl acetate, the extract was washed with saturated brine, then dried and concentrated. To a solution of 647 mg of the obtained residue in 10 ml of tetrahydrofuran was added 2 ml of 1 M tetrabutylammonium fluoride in tetrahydrofuran under ice-cooling and stirred for 30 minutes. The obtained reaction mixture was poured into 2 N aqueous hydrochloric acid under ice-cooling to acidify and extracted with ethyl acetate. The ethyl acetate layer was washed with water, 5% aqueous sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 2:1) to give 275 mg of the compound (I-4) (62% yield) as powders. 
     Reference Example 3 
     Synthesis of the Compound (III-2) 
                         
(Step 1) Synthesis of the Compound 13
 
     To 26 ml of a solution of 2.61 g (10 mmol) of a compound 12 (Journal of Organic Chemistry, 1987, 52, 4485) in dimethylformamide were added 400 mg (10 mmol) of 60% sodium hydride dispersion in oil and 836 mg (11 mmol) of chloromethyl methyl ether under ice-cooling and stirred for 30 minutes. After warming to room temperature, it was further stirred for 1 hours. The reaction mixture was concentrated under reduced pressure and extracted with ethyl acetate. The extract was washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was recrystallized from ethyl acetate-hexane-pentane to give the compound 13 (2.8 g; 92% yield). 
     (Step 2) Synthesis of the Compound 14 
     Using an analogous procedure for the compound 8, the compound 14 was obtained as a pale yellow oil (96% yield) from the compound 13 and the compound 15 (Tokyo Kasei Kogyo Co., Ltd.). 
     (Step 3) Synthesis of the Compound 16 
     To 16 ml of a suspension of 1.38 g (4.3 mmol) of the compound 14 in methanol was added 4 ml of 2 N aqueous hydrochloric acid and stirred for 1 hour under warming at 60° C. The reaction mixture was concentrated under reduced pressure and extracted with ethyl acetate. The extract was washed with 5% aqueous sodium bicarbonate and saturated brine successively, then dried and concentrated to give the compound 16 (1.12 g; 94% yield) as a yellow crystalline residue. 
     (Step 4) Synthesis of the Compound (III-2) 
     To 12 ml of a solution of the compound 16 (1.12 g; 4.05 mmol) in anhydrous dichloromethane was added 1.02 ml (6.08 mmol) of trifluoromethanesulfonic anhydride and then 980 ml (12.2 mmol) of pyridine under ice-cooling and stirred for 30 minutes. The reaction mixture was allowed to warm to room temperature and stirred for additional 2 hours and the solvent was removed. The residue was extracted with ethyl acetate, washed with 5% aqueous sodium bicarbonate and saturated brine successively, then dried and concentrated. The obtained crude product was purified by silica gel chromatography to give 1.23 g of the compound (III-2) (74% yield) as a white crystalline residue. 
     Example 3 
     Synthesis of the Compounds (I-5), (I-6) and (I-7) 
                         
(Step 1) Synthesis of the Compound (I-5)
 
     Using an analogous procedure for the compound 1 in Example 1, 634 mg (0.972 mmol) of the compound (I-5) was synthesized from 881 mg (1.50 mmol) of the compound (III-11) and 370 mg (1.95 mmol) of 3-trifluoromethyl boric acid. 65% yield. 
     (Step 2) Synthesis of the Compound 18 
     Using an analogous procedure for the compound 3 in Example 1, the compound 18 (360 mg; 0.640 mmol) was synthesized from 433 mg (0.664 mmol) of the compound (I-5). 96% yield. 
     (Step 3) Synthesis of the Compound (I-6) 
     Using an analogous procedure for the compound (I-3) in Example 1, 185 mg (0.293 mmol) of the compound (I-6) was synthesized from the compound 18 (170 mg; 0.302 mmol). 97% yield. 
     (Step 4) Synthesis of the Compound (I-7) 
     Using an analogous procedure for the compound (I-1) in Example 1, 85 mg (0.179 mmol) of the compound (I-7) was synthesized from 150 mg (0.238 mmol) of the compound (I-6). 75% yield. 
     Reference Example 4 
     Synthesis of the Compound (III-11) 
                         
(Step 1) Synthesis of the Compound 19
 
     Using an analogous procedure for the compound 10 in Reference Example 2, the compound 19 (24.04 g; 103 mmol) was synthesized from the compound 7 (40.03 g; 163 mmol). 63% yield. 
     (Step 2) Synthesis of the Compound 20 
     To a solution of tert-butylamine (5.0 ml; 47.8 mmol) in 10 ml of toluene was added iodine (5.94 g; 23.39 mmol) under a nitrogen atmosphere and stirred for 50 minutes at room temperature. The compound 19 (5.46 g; 23.43 mmol) was added to the solution under ice-cooling, then warmed to room temperature and stirred for 6 days. The reaction mixture was poured into 1 M of aqueous sodium thiosulfate and extracted with ethyl acetate. The extract was washed with 1 M aqueous sodium thiosulfate and saturated brine successively, then dried and concentrated to give the compound 20 (8.30 g; 23.16 mmol). 99% yield. 
     (Step 3) Synthesis of the Compound 21 
     Using an analogous procedure for the compound 1 in Example 1, the compound 21 (2.10 g; 4.87 mmol) was synthesized from the compound 20 (8.70 g; 24.20 mmol). 20% yield. 
     (Step 4) Synthesis of the Compound (III-11) 
     Using an analogous procedure for the compound (I-2) in Example 1, 2.61 g (4.44 mmol) of the compound (III-11) was synthesized from the compound 21 (3.20 g; 7.42 mmol). 60% yield. 
     Example 4 
     Synthesis of the Compound (I-9) 
                         
(Step 1) Synthesis of the Compound 22
 
     Using an analogous procedure described in Reference Example 1, 1.53 g (3.63 mmol) of the compound (I-1) was silylated and the obtained crude product was crystallized from methanol to obtain the compound 22 (2.62 g; 95% yield) as colorless crystals. 
     (Step 2) Synthesis of the Compound 23 
     To a solution of the compound 22 (2.38 g; 3.1 mmol) in 90 ml of acetone were added 415 mg (3.74 mmol) of trimethylamine-N-oxide dihydrate and 1.60 ml of 5% aqueous solution of osmium tetroxide (0.3 mmol) and stirred for 1 hour at room temperature. After 20 ml of water was added to the reaction mixture, 4.0 g of sodium bicarbonate and 4.0 g of sodium bisulfite were added and stirred for 30 minutes. The reaction mixture was concentrated under reduced pressure and the residue was extracted with ethyl acetate. The extract was washed with saturated brine, then dried and concentrated. 
     A solution of 1.96 g (9.16 mmol) of sodium periodate in 33 ml of water was added dropwise to a solution of 2.46 g of the residue obtained by the above method in 90 ml of ethanol with stirring at room temperature. After stirring for 2 hours, 100 ml of water was added to the reaction mixture and the precipitate was collected by filtration and dried to give the compound 23 (1.98 g; 87% yield) as powder. 
     (Step 3) Synthesis of the Compound (I-9) 
     To a suspension of 146 mg (0.38 mmol) of n-propyltriphenylphosphonium bromide in 2.5 ml of anhydrous tetrahydrofuran was added 32 mg (0.29 mmol) of potassium tert-butoxide in a nitrogen atmosphere at 0° C. and stirred at the same temperature for 1 hour. The reaction mixture was cooled to −78° C., a solution of the compound 23 (70 mg; 0.095 mmol) in 1.5 ml of anhydrous tetrahydrofuran was added and stirred for 30 minutes at the same temperature and for additional 1 hour at room temperature. The reaction mixture was poured into an ice-cooling aqueous solution of saturated ammonium chloride and extracted with ethyl acetate. The extract was washed with saturated brine, then dried and concentrated. 
     Using an analogous procedure described in Example 2 Step 2, 70 mg of the residue obtained by the above method was desilylated and the obtained crude product was purified by silica gel chromatography (toluene-ethyl acetate 4:1) to give 37 mg of the compound (I-9) as pale yellow crystals. 
     Example 5 
     Synthesis of the Compound (I-565) 
                         
(Step 1) Synthesis of the Compound (I-563)
 
     Using an analogous procedure for the compound 2 in Example 1, 850 mg of the compound (1–563) was obtained from a compound (III-27) (800 mg; 1.59 mmol) and the compound 2 (1.25 g; 3.50 mmol) as colorless crystals (86% yield). 
     (Step 2) Synthesis of the Compound (I-565) 
     To a solution of 120 mg (0.193 mmol) of the compound (I-563) in 3 ml dimethoxyethane and 1 ml of ethyl acetate was added 2.4 ml of 4 N hydrochloric acid at 40° C. and stirred at the same temperature for 2 hours 20 minutes. After cooling, the reaction mixture was neutralized with aqueous solution of saturated sodium bicarbonate and extracted with ethyl acetate. The extract was washed with saturated aqueous solution of sodium bicarbonate and saturate brine, then dried and concentrated. The obtained crude product was crystallized from hexane-ethyl acetate to give 93 mg of the compound (I-565) as pale yellow crystals (92% yield). 
     Reference Example 5 
     Synthesis of the Compound (III-27) 
                         
(Step 1) Synthesis of the Compound 24
 
     In a mixture of 17.5 ml of tert-butanol and 5.3 ml of 2-methyl-2-butene was suspended 415 mg (1.00 mmol) of the compound (III-24), 6.7 ml of aqueous solution of 724 mg (8.00 mmol) of sodium chlorite and 968 mg (6.20 mmol) of sodium dihydrogen phosphate dihydrate was added and stirred at the same temperature for 4 hours 30 minutes. The solution of 1 M sodium thiosulfate was added to the reaction mixture and the mixture was extracted with ethyl acetate. Then, organic layer was extracted with aqueous solution of saturated sodium bicarbonate. Then the aqueous layer was acidified with conc. hydrochloric acid and extracted with ethyl acetate. The extract was washed with saturated brine, then dried and concentrated to give the compound 24 (384 mg; 89% yield) as colorless crystals. 
     (Step 2) Synthesis of the Compound (III-27) 
     To 10 ml of a suspension of the compound 24 (1.50 g; 3.48 mmol) in tert-butanol were added 0.533 ml (3.83 mmol) of triethylamine, followed by 0.825 ml (3.83 ml) of diphenyl phosphate azide, and the mixture was stirred at 100° C. for 23 hours. After the reaction mixture was cooled, water was added to it and the mixture was extracted with ethyl acetate. The extract was washed with saturated aqueous solution of sodium bicarbonate and saturated brine, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 2.5:1) to give 1.43 g of the compound (III-27) as colorless form product (82% yield). 
     Example 6 
     Synthesis of the Compound (1–480) 
     
       
         
         
             
             
         
       
     
     To a solution of 120 mg of a compound which was eliminated a Boc group of the compound (I-479) in 2 ml of tetrahydrofuran and 0.5 ml of methanol were added 33 ml (0.34 mmol) of 3-methyl-2-butenal and 90 ml (0.26 mmol) of 3 M aqueous solution of sulfuric acid at 0° C. and stirred for 10 minutes. Further, 19.6 mg of sodium borohydride was added in small portions to the mixture and stirred at room temperature for 1 hour. The saturated aqueous solution of sodium bicarbonate was added to the reaction mixture and extracted with ethyl acetate. The extract was washed with saturated brine, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 3:1) to give 98 mg of the compound (I-480) as colorless crystals (78% yield). 
     Example 7 
     Synthesis of the Compound (I-628) 
     
       
         
         
             
             
         
       
     
     Using an analogous procedure for the compound 1 in Example 1, 1.2 g (2 mmol) of the compound (III-44) was reacted with 551 mg (2.2 mmol) of 4-bromomethanesulfonyl anilide were reacted, followed by desilylated by an analogous procedure described in Example 1 Step 2. The obtained crude product was crystallized from ethyl acetate-hexane to obtain 760 mg of the compound (I-628) as pale yellow crystals (73% yield). 
     Reference Example 6 
     Synthesis of the Compound (III-44) 
                         
(Step 1) Synthesis of the Compound 25
 
     Using an analogous procedure for the compound 5 in Reference Example 1, a crude product was synthesized by the reaction of 22.2 g (52.7 mmol) of the compound 21, 8.95 g (132 mmol) of imidazole and 17.5 g (1.16 mmol) of tert-butyldimethylsilyl chloride. The obtained product was purified by silica gel chromatography (ethyl acetate:hexane=1:20) and crystallized from ethyl acetate-hexane to give 29.7 g of the compound 25 as colorless crystals (85% yield). 
     (Step 2) Synthesis of the Compound (III-44) 
     Using an analogous procedure for the compound 2 in Reference Example 1,402.7 g (610 mmol) of the compound 25 was reacted with 678 ml (814 mmol) of 1.08 N s-butyl lithium in cyclohexane, followed by addition of 282 ml (1.22 mol) of triisopropyl borate to give 246 g of the compound (III-44) as colorless powders (65% yield). 
     Example 8 
     Synthesis of the Compound (I-233) 
     
       
         
         
             
             
         
       
     
     In an argon atmosphere, 2.87 g (8.0 mmol) of the compound 20 was dissolved in 32 ml of dimethoxyethane and 8 ml of ethanol, 3.01 g of the compound 2 and 16 ml of 2 M aqueous solution of sodium carbonate were added and the reaction mixture was degassed. To the mixture was added 462 mg (0.4 mmol) of palladium tetrakistriphenylphosphine and the mixture was heated under refluxing for 2 hours. After the reaction mixture was cooled to room temperature, 2.02 g (12.0 mmol) of 4-methylthiophenyl boronic acid, 462 mg (0.4 mmol) of palladium tetrakistriphenylphosphine, 16 ml of 2 M aqueous solution of sodium carbonate, 32 ml of dimethoxyethane and 8 ml of ethanol were added to it. Then, the reaction mixture was degassed again and heated under refluxing for 16 hours. After the reaction mixture was cooled to room temperature, 100 ml of 5% aqueous citric acid was added and stirred at the same temperature for 1 hour. Ethyl acetate was added to the reaction mixture and the organic layer was washed with 5% aqueous citric acid, water, saturated aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 3:1) to obtain 2.13 g of crude crystals. The obtained crude crystals were recrystallized from hexane-ethyl acetate to give 1.66 g of the compound (1–233) as colorless crystals (44% yield) 
     Example 9 
     Synthesis of other Compounds 
     Following compounds (I) were synthesized by analogous procedures described above. The structures and physical constants of the compounds (III) and (I) are as follows. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 1 
               
               
                   
               
             
            
               
                 III-1 
                 m.p. 201–203° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.44(s, 3H), 3.48(s, 3H), 3.62(s, 3H), 3.92(s, 3H), 7.09(s, 1H), 7.40–7.53(m, 2H), 7.65–7.78(m, 2H) 
               
               
                 III-2 
                   1 HNMR(CDCl 3 ) δ 3.47(s, 3H), 3.94(s, 3H), 7.13–7.24(m, 3H), 7.50–7.59(m, 2H), 10.41(s, 1H) 
               
               
                   
                 IR(KBr)1700, 1562, 1479, 1438, 1393, 1226, 1199, 1180, 1161, 1076, 1047cm −1   
               
               
                 III-3 
                 m.p. 181–182° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.21(s, 3H), 3.40(s, 3H), 3.49(s, 3H), 3.90(s, 3H), 4.81(s, 2H), 4.85(s, 2H), 6.86(s, 1H), 7.32–7.40(m, 2H), 7.60–7.68(m, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr)1504, 1467, 1370, 1235, 1152, 1038, 1010, 870, 846, 785cm −1   
               
               
                 III-4 
                   1 HNMR(CDCl 3 ) δ 2.95(s, 3H), 3.18(s, 3H), 3.21(s, 3H), 3.41(s, 3H), 3.91(s, 3H), 6.84(s, 1H), 7.37(d, J=8.9Hz, 2H), 7.63(d, J=8.9Hz, 2H) 
               
               
                 III-5 
                 m.p. 140–141° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.21(s, 3H), 3.45(s, 3H), 3.48(s, 3H), 3.96(s, 3H), 7.40(d, J=8.9Hz, 2H), 7.54(d, J=8.9Hz, 2H) 
               
               
                   
                 IR(KBr)1446, 1426, 1409, 1370, 1362, 1184, 1153, 1029, 973, 920, 870, 849, 776cm −1   
               
               
                 III-6 
                 Tokyo Kasei Kogyo Co., Ltd. 
               
               
                 III-7 
                   1 HNMR(CDCl 3 ) δ: 3.51(s, 3H), 3.92(s, 3H), 6.05(s, 2H), 6.92(d, J=8.1Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.07(s, 1H), 7.18(s, 1H), 10.40(s, 1H) 
               
               
                   
                 IR(KBr)1691, 1600, 1577, 1474, 1447, 1422, 1388, 1352, 1252, 1237, 1227, 1201, 1134, 1124, 1082, 1038cm −1   
               
               
                 III-8 
                   1 HNMR(CDCl 3 ) δ 3.20(s, 3H), 3.77(s, 3H), 3.90(s, 3H), 6.86(s, 1H), 6.98(s, 1H), 7.32–7.37(m, 2H), 7.51–7.56(m, 2H) 
               
               
                 III-9 
                 HNMR(CDCl 3 ) δ 3.20(s, 3H), 3.34(s, 3H), 7.37–7.47(m, 3H), 7.53–7.63(m, 3H), 7.71(d, J=2.1Hz, 1H) 
               
               
                 III-10 
                   1 HNMR(CDCl 3 ) δ 3.76(s, 3H), 3.90(s, 3H), 6.85(s, 1H), 6.97(s, 1H), 7.08–7.15(m, 2H), 7.42–7.49(m, 2H) 
               
               
                 III-11 
                 oil 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.72(s, 3H), 3.11(s, 3H), 3.75(s, 3H), 3.92(s, 3H), 5.17(s, 2H), 7.05–7.16(m, 2H), 7.24–7.50(m, 2H). 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 2 
               
               
                   
               
             
            
               
                 III-12 
                 oil 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.51(s, 3H), 3.70(s, 3H), 3.86(s, 3H), 3.89(s, 3H), 5.28(s, 2H), 6.65(s, 1H), 6.97&amp;7.47(ABq, J=8.6Hz, 4H) 
               
               
                 III-13 
                 m.p. 120–122° C.  1 HNMR(CDCl 3 ) δ 3.20(s, 3H), 3.53(s, 3H), 3.70(s, 3H), 3.89(s, 3H), 5.28(s, 2H), 6.63(s, 1H), 7.32–7.37(m, 2H), 7.56–7.61 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(KBr)1505, 1468, 1427, 1375, 1237, 1175, 1153, 1100, 1072, 1003, 972cm  −1   
               
               
                 III-14 
                 m.p. 146–147° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.85(s, 3H), 6.94–7.01(m, 2H), 7.38–7.56(m, 6H) 
               
               
                   
                 IR(KBr)1603, 1522, 1481, 1288, 1255, 1036cm −1   
               
               
                 III-15 
                   1 HNMR(CDCl 3 ) δ 3.07(s, 6H), 3.49(s, 3H), 3.92(s, 3H), 6.95(brs, 2H), 7.20(s, 1H)7.51(d, J=8.7Hz, 2H), 10.42(s, 1H) 
               
               
                 III-16 
                   1 HNMR(CDCl 3 ) δ 3.48(s, 3H), 3.50(s, 3H), 3.92(s, 3H), 6.81(s, 1H), 7.70(s, 4H) 
               
               
                 III-17 
                   1 HNMR(CDCl 3 ) δ 3.24(s, 3H), 3.49(s, 3H), 3.94(s, 3H), 7.21(s, 1H), 7.42(d, J=8.4Hz, 2H), 7.65(d, J=8.4Hz, 2H), 10.41(s, 1H) 
               
               
                 III-18 
                 m.p. 88–89° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.20(s, 3H), 2.38(s, 3H), 3.19(s, 3H), 7.06(s, 1H), 7.33(s, 4H), 7.45(s, 1H) 
               
               
                   
                 IR(KBr)1479, 1366, 1195, 1173, 1151, 970, 865, 850, 796cm −1   
               
               
                 III-19 
                 m.p. 72–73° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.20(s, 3H), 7.20(dd, J=6.6, 8.4Hz, 1H), 7.35–7.44(m, 3H), 7.53–7.60(m, 2H) 
               
               
                   
                 IR(KBr)1514, 1481, 1364, 1335, 1182, 1144, 979, 870, 798cm −1   
               
               
                 III-20 
                 m.p. 144–146° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.89(s, 3H), 4.99(brs, 2H), 6.19(s, 1H), 6.42(s, 1H), 6.88–6.94(m, 2H), 7.44–7.49(m, 2H) 
               
               
                   
                 IR(KBr)3471, 3392, 29863, 1612, 1596, 1461, 1410, 1223, 1175, 1099, 1079, 1011cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 3 
               
               
                   
               
             
            
               
                 III-21 
                 oil 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.09(t, J=7.5Hz, 3H), 1.82–1.94(m, 2H), 3.58(s, 3H), 3.86(s, 3H), 4.06(t, J=6.6Hz, 2H), 6.63(s, 1H), 6.94–6.99(m, 
               
               
                   
                 2H), 7.44–7.49(m, 2H) 
               
               
                   
                 IR(film): 3100–2800(br), 1609, 1583, 1513, 1466, 1423, 1401, 1378, 1291, 1249, 1232, 1178, 1127, 1097, 1034, 1012cm −1   
               
               
                 III-22 
                 m.p. 83.5–84.5° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.20(br, 1H), 3.54(s, 3H), 3.85–3.90(m, 2H), 3.86(s, 3H), 3.90(s, 3H), 4.29–4.32(m, 2H), 6.66(s, 1H), 6.95–7.00(m, 2H), 
               
               
                   
                 7.45–7.50(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1608, 1583, 1513, 1467, 1441, 1421, 1398, 1365, 1290, 1247, 1178, 1133, 1097, 1079, 1028, 1007cm −1   
               
               
                 III-23 
                 m.p. 99–101° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.20(s, 3H), 3.39(s, 3H), 3.91(s, 3H), 3.99(s, 3H), 6.89(s, 1H), 7.37(d, J=8.7Hz, 2H), 7.64(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)1747, 1466, 1367, 1348, 1153, 1059, 968, 859, 794cm −1   
               
               
                 III-24 
                   1 HNMR(CDCl 3 ) δ 3.22(s, 3H), 3.45(s, 3H), 3.94(s, 3H), 7.04(s, 1H), 7.32–7.43(m, 2H), 7.58–7.69(m, 2H), 10.42(s, 1H) 
               
               
                 III-25 
                   1 HNMR(CDCl 3 ) δ 2.46(broad, 1H), 3.21(s, 3H), 3.43(s, 3H), 3.90(s, 3H), 4.94(s, 2H), 6.83(s, 1H), 7.42–7.51(m, 2H), 7.57–7.68(m, 2H) 
               
               
                 III-26 
                 m.p. 109–110° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.97(br, 1H), 3.21(t, J=6.6Hz, 2H), 3.86(s, 3H), 3.89(s, 3H), 3.90(t, J=6.9Hz, 2H), 6.76(s, 1H), 6.95–7.00(m, 2H), 7.49– 
               
               
                   
                 7.53(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1609, 1581, 1511, 1462, 1441, 1426, 1385, 1289, 1250, 1237, 1179, 1116, 1078, 1046, 1031, 1005cm −1   
               
               
                 III-27 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.52(s, 9H), 3.20(s, 3H), 3.41(s, 3H), 3.90(s, 3H), 6.16(s, 1H), 6.76(s, 1H), 7.35(d, J=8.7Hz, 2H), 7.61(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3371, 1718, 1505, 1497, 1367, 1241, 1151, 872cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 4 
               
               
                   
               
             
            
               
                 III-28 
                 m.p. 167–170° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.73(s, 3H), 3.74(s, 3H), 3.92(s, 3H), 7.08–7.17(m, 3H), 7.31–7.36(m, 2H) 
               
               
                   
                 IR(CHCl 3 )2934, 1593, 1560, 1512, 1477, 1436, 1411, 1372, 1157, 1107, 1076, 997, 958, 892, 839, 815cm −1   
               
               
                 III-29 
                 m.p. 140–142° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.27(s, 3H), 3.79(s, 3H), 3.90(s, 3H), 6.86(s, 1H), 6.97(s, 1H), 7.29(ddd, J=8.4, 2.2, 0.9Hz, 1H), 7.39(dd, J=11.0, 2.2Hz, 
               
               
                   
                 1H), 7.43(t, J=8.4Hz, 1H) 
               
               
                   
                 IR(KBr)1504, 1421, 1344, 1225, 1208, 916, 824cm −1   
               
               
                 III-30 
                   1 HNMR(CDCl 3 ) δ 3.77(s, 3H), 3.91(s, 3H), 3.95(s, 3H), 6.87(s, 1H), 7.01(s, 1H), 7.56(d, J=8.1Hz, 2H), 8.09(d, J=8.1Hz, 2H) 
               
               
                 III-31 
                   1 HNMR(CDCl 3 ) δ 3.78(s, 3H), 3.91(s, 3H), 6.88(s, 1H), 6.97(s, 1H), 7.60(d, J=8.1Hz, 2H), 7.7(d, J=8.1Hz, 2H) 
               
               
                 III-32 
                 m.p. 147–148° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.79(s, 3H), 3.92(s, 3H), 6.89(s, 1H), 7.01(s, 1H),7.64–7.69(m, 2H), 8.26–8.31(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1595, 1511, 1490, 1422, 1354, 1249, 1215, 1145, 1106, 1032cm −1   
               
               
                 III-33 
                   1 HNMR(CDCl 3 ) δ 3.31(s, 3H), 3.53(s, 3H), 3.94(s, 3H), 7.19(s, 1H), 7.39(ddd, J=8.3, 2.3, 1.0Hz, 1H), 7.39(dd, J=10.3, 2.3Hz, 1H), 
               
               
                   
                 7.43(t, J=8.31Hz, 1H), 10.40(s, 1H) 
               
               
                 III-34 
                   1 HNMR(CDCl 3 ) δ 0.13(s, 6H), 0.97(s, 9H), 2.51(s, 3H), 3.73(s, 3H), 3.93(s, 3H), 5.09(s, 2H), 6.84–6.99(m, 2H), 6.89(s, 1H), 7.05(s, 1H), 
               
               
                   
                 7.29–7.48(m, 5H) 
               
               
                 III-35 
                 m.p. 124–128° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.62(s, 3H), 3.74(s, 3H), 3.91(s, 3H), 5.19(s, 2H), 7.00–7.18(m, 4H), 7.30–7.49(m, 5H) 
               
               
                   
                 IR(CHCl 3 )2930, 1607, 1517,1480, 1369, 1148, 1118, 1082, 1025, 969, 872cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 5 
               
               
                   
               
             
            
               
                 III-36 
                 oil 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 0.13(s, 6H), 0.96(s, 3H), 3.01(s, 3H), 3.69(s, 3H), 3.86(s, 3H), 4.81(s, 2H), 5.08(s, 2H), 6.88–6.94(m, 3H), 7.30–7.47(m, 
               
               
                   
                 5H) 
               
               
                   
                 IR(KBr)3023, 2932, 2858, 1579, 1512, 1471, 1381, 1264, 1120, 1083cm −1   
               
               
                 III-37 
                 oil 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 0.78(t, J=7.5Hz, 3H), 1.03–1.25(m, 2H), 1.38–1.47(m, 2H), 3.68–3.72(m, 2H), 3.70(s, 3H), 3.86(s, 6H), 5.15(s, 2H), 5.6 
               
               
                   
                 3(s, 1H), 6.81(dd, J=1.8, 8.4Hz, 1H), 6.86(s, 1H), 6.95–6.97(m, 2H), 7.36–7.46(m, 5H) 
               
               
                   
                 IR(CH 3 Cl): 3543, 3200–2800(br), 1587, 1511, 1465, 1412, 1376, 1285, 1248, 1118, 1081, 1031cm −1   
               
               
                 III-38 
                 m.p. 104–105° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.11(s, 3H), 3.77(s, 3H), 3.90(s, 3H), 5.17(s, 2H), 6.84(s, 1H), 6.98(s, 1H), 7.11(d, J=8.7Hz, 1H), 7.37–7.48(m, 6H), 7.5 
               
               
                   
                 1(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1503, 1420, 1389, 1364, 1246, 1215, 1185, 1132, 1117, 1097, 1030cm −1   
               
               
                 III-39 
                 m.p. 134–136° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.78(s, 3H), 3.91(s, 3H), 5.29(s, 2H), 6.86(s, 1H), 6.97(s, 1H), 7.17(d, J=8.7Hz, 1H), 7.31–7.51(m, 7H), 7.63(dd, J=2.4, 
               
               
                   
                 8.7Hz, 1H), 8.01(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(KBr)3434, 1620, 1532, 1494, 1413, 1280, 1222, 1206, 1133, 1108, 1037cm −1   
               
               
                 III-40 
                 m.p. 100–101° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.55(s, 3H), 3.77(s, 3H), 3.90(s, 3H), 5.26(s, 2H), 6.84(s, 1H), 6.97(s, 1H), 7.16–7.31(m, 3H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1524, 1503, 1449, 1401, 1380, 1268, 1246, 1222, 1200, 1156, 1126, 1098, 1078, 1030cm −1   
               
               
                 III-41 
                 m.p. 109–110° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.54(s, 9H), 3.76(s, 3H), 3.90(s, 3H), 6.75(br, 1H), 6.84(s, 1H), 6.97(s, 1H), 7.21–7.29(m, 2H), 8.13(t, J=8.7Hz, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1720, 1593, 1531, 1509, 1427, 1393, 1245, 1223, 1214, 1201, 1162, 1137, 1105, 1029cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 6 
               
               
                   
               
             
            
               
                 III-42 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.36(s, 3H), 3.74(s, 3H), 3.88(s, 3H), 6.69(dd, J=0.6, 3.6Hz, 1H), 6.85(s, 1H), 6.99(s, 1H), 7.24–7.27(m, 2H), 
               
               
                   
                 7.23(dd, J=1.8,8.7Hz, 1H), 7.60(d, J=3.6Hz, 1H), 7.64(d, J=1.2Hz, 1H), 7.80–7.83(m, 2H), 8.02(d, J=8.4Hz, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1508, 1463, 1444, 1421, 1373, 1246, 1216, 1176, 1132, 1093, 1038cm −1   
               
               
                 III-43 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.14(s, 3H), 3.51(s, 3H), 3.93(s, 3H), 5.20(s, 2H), 7.17(d, J=8.4Hz, 1H), 7.20(s, 1H), 7.38(m, 6H), 7.59(d, J=1.8Hz, 1H), 
               
               
                   
                 10.40(s, 1H) 
               
               
                   
                 IR(CHCl 3 )2941, 1703, 1613, 1603, 1580, 1513, 1475, 1426, 1372, 1295, 1264, 1169, 1137, 1112, 1088, 1044, 971, 954, 932, 838cm −1   
               
               
                 III-44 
                   1 HNMR(CDCl 3 ) δ 0.20(s, 6H), 0.13(s, 6H), 0.77(s, 9H), 0.97(s, 9H), 3.73(s, 3H), 3.83(s, 3H)), 5.08(s, 2H), 6.06(s, 2H), 6.88–6.96(m, 3H), 7.01 
               
               
                   
                 (s, 1H), 7.30–7.49(m, 5H) 
               
               
                 III-45 
                 mp 106–108° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.21(s, 3H), 3.43(s, 3H), 3.94(s, 3H), 5.87(s, 1H), 7.39(d, J=9.0Hz, 2H), 7.55(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3410, 1460, 1422, 1362, 1146, 1037, 874, 915, 787cm −1   
               
               
                 III-46 
                 mp 123–124° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.48(brs, 1H), 3.21(s, 3H), 3.43(s, 3H), 3.94(s, 3H), 4.93(brs, 2H), 6.83(s, 1H), 7.37(d, J=9.0Hz, 2H), 7.63(d, 
               
               
                   
                 J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3524, 1463, 1352, 1233, 1152, 1009, 979, 869cm −1   
               
               
                 III-47 
                 mp 107–109° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.93(s, 6H), 2.45(s, 6H), 4.75(brs, 1H), 6.87–6.96(m, 4H) 
               
               
                   
                 IR(KBr)3367, 1612, 1509, 1433, 1214, 990, 824cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 7 
               
               
                   
               
             
            
               
                 III-48 
                 oil 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.14(t, J=6.9Hz, 3H), 1.46(t,J=6.9Hz, 3H), 3.58(q, J=6.9Hz, 2H), 3.58(q, J=6.9Hz, 2H), 6.19(s, 1H), 
               
               
                   
                 6.41(s, 1H), 6.86–6.92(m, 2H), 7.43–7.49(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3688, 3594, 3502, 2982, 1612, 1517, 1172, 1080, 1026, 925cm −1   
               
               
                 III-49 
                   1 HNMR(CDCl 3 ) δ 0.02(s, 6H), 0.12(s, 6H), 0.90(s, 9H), 0.93(s, 9H), 4.54(s, 2H), 4.76(s, 2H), 6.84–6.89(m, 2H), 7.16–7.22(m, 2H), 
               
               
                   
                 7.37(s, 1H), 7.69(s, 1H) 
               
               
                 III-50 
                 mp173–175° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.21(s, 3H), 3.47(s, 3H), 3.89(s, 3H), 6.15(s, 1H), 6.42(s, 1H), 7.24–7.37(m, 2H), 7.61–7.66(m, 2H) 
               
               
                   
                 IR(KBr)3408, 2934, 1604, 1480, 1360, 1146, 1089, 1004, 865, 709, 547cm −1   
               
               
                 III-51 
                 mp156–158° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.21(s, 3H), 3.39(s, 3H), 3.90(s, 3H), 6.05(s, 1H), 7.36–7.44(m, 4H) 
               
               
                   
                 IR(KBr)3410, 2938, 1505, 1457, 1413, 1337, 1194, 1143, 1084, 1014, 876, 826, 542, 519cm −1   
               
               
                 III-52 
                 mp181–183° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.19(s, 3H), 3.88(s, 3H), 4.21–4.24(m, 2H), 4.39–4.42(m, 2H), 6.49(s, 1H), 7.45(ABq, J=8.7Hz, 4H) 
               
               
                   
                 IR(KBr)3435, 1598, 1505, 1474, 1425, 1366, 1178, 1147, 1113cm −1   
               
               
                 III-53 
                 mp155–157° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ −0.11–0.02(m, 2H), 0.33–0.44(m, 2H), 0.91(m, 1H), 3.20(s, 3H), 3.41(d, J=7.0Hz, 2H), 3.50(s, 3H), 3.92(s, 3H), 
               
               
                   
                 6.88(s, 1H), 7.51(ABq, J=8.6Hz, 4H) 
               
               
                   
                 IR(KBr)3434, 1505, 1472, 1416, 1386, 1371, 1357, 1242, 1179, 1149, 1084cm −1   
               
               
                 III-54 
                 mp105–107° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.20(s, 3H), 3.39(s, 3H), 3.89(s, 3H), 4.77(s, 2H), 6.40(s, 1H), 7.33–7.55(m, 5H) 
               
               
                   
                 IR(KBr)3411, 1592, 1572, 1507, 1482, 1467, 1437, 1360, 1339, 1232, 1204, 1175, 1148, 1125, 1092cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 8 
               
               
                   
               
             
            
               
                 III-55 
                 mp 138–140° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.14(t, J=7.0Hz, 3H), 3.59(q, J=7.0Hz, 2H), 3.88(s, 3H), 4.97(bs, 1H), 6.42(s, 1H), 6.86–6.94(m, 2H), 7.43–7.51(m,2H) 
               
               
                   
                 IR(KBr)3384, 3291, 2978, 1614, 1593, 1576, 1519, 1484, 1469, 1455, 1436, 1417, 1366, 1306, 1285, 1257, 1203, 1171, 1127, 1094, 1029cm −1   
               
               
                 III-56 
                 mp 162–164° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.77(s, 3H), 3.17(s, 3H), 3.75(s, 3H), 3.92(s, 3H), 7.10(s, 2H), 7.35–7.43(m, 4H) 
               
               
                   
                 IR(CHCl 3 )1594, 1561, 1507, 1478, 1464, 1374, 1331, 1178, 1149, 1109, 1080, 1000, 970, 894, 871, 844cm −1   
               
               
                 III-57 
                 mp 95–97° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.35(s, 3H), 3.77(s, 3H), 6.84–6.87(m, 2H), 7.12(s, 1H), 7.13(s, 1H), 7.35–7.38(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3596, 2959, 2939, 2840, 1611, 1563, 1517, 1489, 1464, 1438, 1384, 1367, 1329, 1295, 1258, 1173, 1102, 1049, 1035, 1001, 911, 
               
               
                   
                 891, 835cm −1   
               
               
                 III-58 
                 mp 173–175° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 6.91–6.94(m, 2H), 7.31–7.34(m, 2H), 7.87(s, 1H), 8.09(s, 1H), 9.89(s, 1H), 10.28(s, 1H) 
               
               
                   
                 IR(CHCl 3 )3437, 1685, 1610, 1516, 1456, 1394, 1370, 1270, 1261, 1238, 1214, 1173, 1144, 1053, 1012, 939, 905, 829, 808, 557, 458cm −1   
               
               
                 III-59 
                 mp 173–175° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.10(t, J=6.9Hz, 3H), 1.48(t, J=6.9Hz, 3H), 3.20(s, 3H), 3.47(s, 3H), 3.66(q, J=6.9Hz, 2H), 4.11(q, J=6.9Hz, 2H), 
               
               
                   
                 6.79(s, 1H), 7.32–7.39(m, 2H), 7.60–7.66(m, 2H) 
               
               
                   
                 IR(CHCl 3 )1502, 1458, 1372, 1176, 1148, 1074, 1023, 967, 870cm −1   
               
               
                 III-60 
                   1 HNMR(CDCl 3 ) δ 2.17(s, 3H), 2.39(s, 3H), 3.19(s, 3H), 5.80(s, 1H), 6.71(s, 1H), 7.33(s, 4H) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 9 
               
               
                   
               
             
            
               
                 III-61 
                 mp 107–108° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.21(s, 3H), 3.79(s, 3H), 4.04(s, 3H), 7.39(d, J=8.9Hz, 2H), 7.57(d, J=8.9Hz, 2H), 7.68(s, 1H), 10.17(s, 1H) 
               
               
                   
                 IR(KBr)1704, 1422, 1358, 1224, 1148, 1090, 1026, 974, 876cm −1   
               
               
                 III-62 
                 mp 121–122° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.47(s, 3H), 3.93(s, 3H), 4.68(s, 2H), 4.77(s, 2H), 7.22(s, 1H), 7.49(d, J=8.1Hz, 2H), 7.56(d, J=8.1Hz, 
               
               
                   
                 2H), 10.42(s, 1H) 
               
               
                   
                 IR(KBr)1695, 1476, 1422, 1232, 1189, 1130, 1040, 860cm −1   
               
               
                 III-63 
                 mp 113–115° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.18(s, 3H), 3.22(s, 3H), 3.89(s, 3H), 6.85(s, 1H), 7.11(s, 1H), 7.36(s, 4H) 
               
               
                   
                 IR(KBr)1497, 1413, 1354, 1230, 1146, 1097, 976, 864cm −1   
               
               
                 III-64 
                   1 HNMR(CDCl 3 ) δ 5.65(s, 1H), 7.18(s, 1H), 7.30–7.35(m, 2H), 7.46–7.50(m, 3H) 
               
               
                 III-65 
                   1 HNMR(CDCl 3 ) δ 1.30(d, J=7.2Hz, 6H), 2.96(quintet, J=7.2Hz, 1H), 3.82(s, 3H), 3.91(s, 3H), 5.92(brs, 2H), 6.91(s, 1H), 7.30(d, J=8.1Hz, 
               
               
                   
                 2H), 7.44(s, 1H), 7.49(d, J=8.1Hz, 2H) 
               
               
                 III-66 
                 mp 118–122° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.80(s, 3H), 3.91(s, 3H), 5.88(s, 2H), 6.84–6.92(m, 3H), 7.39–7.47(m, 3H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1606, 1517, 1492, 1461, 1415, 1397, 1330, 1265, 1205, 1171, 1052cm −1   
               
               
                 III-67 
                 mp 227–230° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 0.25(s, 6H), 1.02(s, 9H), 2.33(s, 3H), 2.82(s, 2H), 6.88–6.93(m, 2H), 7.16(s, 1H), 7.21–7.25(m, 3H), 8.11(s, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1608, 1514, 1393, 1346, 1267, 1167cm −1   
               
               
                 III-68 
                 mp 134–137° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.00(s, 6H), 3.81(s, 3H), 3.91(s, 3H), 6.00(s, 2H), 6.77–6.82(m, 2H), 6.90(s, 1H), 7.41(s, 1H), 7.46–7.51(m, 3H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1601, 1528, 1494, 1466, 1439, 1399, 1362, 1321, 1198, 1166, 1118, 1051cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 10 
               
               
                   
               
             
            
               
                 III-69 
                 mp 144–148° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 2.82(s, 3H), 3.01(s, 6H), 7.79–7.83(m, 2H), 7.18(s, 1H), 7.27–7.31(m, 2H), 8.11(s, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1612, 1523, 1443, 1389, 1328, 1271, 1160cm −1   
               
               
                 III-70 
                 mp 122–126° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 0.10(s, 9H), 0.78(s, 6H), 2.96(s, 6H), 3.75(s, 3H), 3.84(s, 3H), 6.08(s, 2H), 6.72–6.78(m, 2H), 7.01(s, 1H), 
               
               
                   
                 7.22–7.29(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1613, 1528, 1463, 1416, 1402, 1360, 1345, 1251, 1218, 1195, 1136, 1092, 1062, 991cm −1   
               
               
                 III-71 
                   1 HNMR(CDCl 3 ) δ 2.21(s, 3H), 2.37(s, 3H), 3.89(s, 3H), 5.19(s, 2H), 6.75(d.d, J=8.4&amp;2.1Hz, 1H), 6.81(d, J=2.1Hz, 1H), 6.92(d, 
               
               
                   
                 J=8.4Hz, 1H), 7.08(s, 1H), 7.30–7.50(m, 6H) 
               
               
                 III-72 
                 oil 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.51(s, 6H), 2.75(s, 6H), 5.15(s, 2H), 5.67(s, 1H), 6.94(s, 1H), 6.96(d, J=8.4Hz, 1H), 7.04(dd, J=2.1, 8.4Hz, 1H), 
               
               
                   
                 7.18(s, 1H), 7.20(d, J=2.1Hz, 1H), 7.37–7.47(m, 5H) 
               
               
                   
                 IR(CHCl 3 )3032, 3428, 3000–2800(br), 1730, 1611, 1525, 1489, 1455, 1256, 1171, 1137, 1100, 1036cm −1   
               
               
                 III-73 
                   1 HNMR(CDCl 3 ) δ 2.21(s, 3H), 2.37(s, 3H), 5.15(s, 2H), 5.69(br, 1H), 6.73(dd, J=8.4, 1.8Hz, 1H), 6.89–6.99(m, 2H), 7.07(s, 1H), 
               
               
                   
                 7.26–7.4 6(m, 6H) 
               
               
                 III-74 
                   1 HNMR(CDCl 3 ) δ 1.09(t, J=7.2Hz, 3H), 1.22(t, J=7.5Hz, 3H), 2.55(q, J=7.2Hz, 2H), 2.72(q, J=7.5Hz, 2H), 5.15(s, 2H), 5.70(s, 1H), 
               
               
                   
                 6.73(dd, J=8.4, 1.8Hz, 1H), 6.89(d, J=1.8Hz, 1H), 6.95(d, J=8.4Hz, 1H), 7.04(s, 1H), 7.38–7.47(m, 6H) 
               
               
                   
                 IR(CHCl 3 )3542, 2970, 2933, 1586, 1508, 1480, 1384, 1324, 1290, 1160, 1127, 1064, 1011, 930, 898, 879, 857cm −1   
               
               
                 III-75 
                   1 HNMR(CDCl 3 ) δ 2.04(s, 3H), 3.70(s, 3H), 3.90(s, 3H), 5.19(s, 2H), 5.50(m, 1H), 6.73(dd, J=2.1Hz, 1H), 6.97–7.00(m, 2H), 
               
               
                   
                 7.29–7.48(m, 5H) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 11 
               
               
                   
               
             
            
               
                 III-76 
                   1 HNMR(CDCl 3 ) δ 2.04(s, 3H), 3.90(s, 3H), 5.15(s, 2H), 5.49(s, 1H), 5.74(s, 1H), 6.71(dd, J=8.1, 2.1Hz, 1H), 6.85(d, J=2.1Hz, 1H), 6.99–7.03 
               
               
                   
                 (m, 2H), 7.39–7.45(m, 5H) 
               
               
                   
                 IR(CHCl 3 )3529, 2963, 2940, 1731, 1587, 1566, 1510, 1480, 1455, 1412, 1382, 1323, 1290, 1248, 1128, 1099, 1009, 935, 879cm −1   
               
               
                 III-77 
                 mp 87–89° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.20(s, 3H), 2.37(s, 3H), 5.18(s, 2H), 6.90–7.10(m, 4H), 730–7.51(m, 6H) 
               
               
                   
                 IR(CHCl 3 )1510, 1482, 1381, 1298, 1267, 1233, 1127, 1008, 952, 875, 812cm −1   
               
               
                 III-78 
                   1 HNMR(CDCl 3 ) δ 1.25(d, J=6.9Hz, 6H), 2.24(s, 3H), 3.26(sept, J=6.9Hz, 1H), 5.20(s, 2H), 6.95(ddd, J=8.3, 2.2, 1.2Hz, 1H), 7.06(t, 
               
               
                   
                 J=8.3Hz, 1H), 7.06(dd, J=11.9, 2.2Hz, 1H), 7.10(s, 1H), 7.17(s, 1H), 7.32–7.51(m, 5H) 
               
               
                   
                 IR(KBr)1492, 1420, 1228, 1203, 1140, 1012, 989, 841cm −1   
               
               
                 III-79 
                   1 HNMR(CDCl 3 ) δ 2.43(s, 3H), 5.19(s, 2H), 7.06(t, J=8.9Hz, 1H), 7.18–7.48(m, 10H) 
               
               
                   
                 IR(KBr)1491, 1437, 1214, 1135, 890, 810, 748cm −1   
               
               
                 III-80 
                 mp 77–79° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.921(s, 3H), 5.21(s, 2H), 6.90–6.99(m, 3H), 7.31–7.50(m, 7H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1518, 1477, 1418, 1237, 1212, 1167, 1140cm −1   
               
               
                 III-81 
                 mp 103–105° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.16(s, 3H), 2.37(s, 3H), 2.42(s, 3H), 3.16(m, 3H), 5.21(s, 2H), 7.16–7.17(m, 3H), 7.24–7.27(m, 1H), 7.36–7.48(m, 5H) 
               
               
                   
                 IR(CHCl 3 )2940, 1613, 1514, 1478, 1455, 1423, 1366, 1331, 1292, 1264, 1176, 1140, 1126, 1096, 1045, 1009, 972, 955, 920, 843cm −1   
               
               
                 III-82 
                   1 HNMR(CDCl 3 ) δ 2.19(s, 3H), 3.88(s, 3H), 5.20(s, 2H), 6.84(s, 1H), 6.95(m, 1H), 7.03–7.05(m, 3H), 7.35–7.49(m, 5H) 
               
               
                 III-83 
                 mp 83–85° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.19(s, 3H), 3.88(s, 3H), 3.91(s, 3H), 5.21(s, 3H), 6.76(dd, J=8.4, 2.1Hz, 1H), 6.82(d, J=2.1Hz, 1H), 6.87(s, 1H), 
               
               
                   
                 6.93(d, J=8.4Hz, 1H), 7.08(s, 1H), 7.32–7.50(m, 5H) 
               
               
                   
                 IR(CHCl 3 )2962, 2937, 1613, 1579, 1499, 1464, 1455, 1443, 1421, 1319, 1249, 1170 1140, 1103, 1029, 1008, 989, 901, 832cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 12 
               
               
                   
               
             
            
               
                 III-84 
                 oil 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.44(d, J=6.9Hz, 3H), 2.19(s, 3H), 4.09(q, J=6.9Hz, 2H), 5.20(s, 2H), 6.82(s, 1H), 6.94–7.08(m, 3H), 
               
               
                   
                 7.32–7.49(m, 6H) IR(CHCl 3 )3597, 2928, 1731, 1609, 1523, 1494, 1476, 1387, 1298, 1261, 1173, 1127, 1048, 834cm −1   
               
               
                 III-85 
                   1 HNMR(CDCl 3 ) δ 2.26(s, 3H), 2.52(s, 3H), 3.90(s, 3H), 4.59(brs, 2H), 5.20(s, 2H), 6.73–7.10(m, 4H), 7.27–7.52(m, 6H) 
               
               
                 III-86 
                   1 HNMR(CDCl 3 ) δ 2.33(s, 3H), 2.81(s, 3H), 4.60(brs, 2H), 5.20(s, 2H), 6.92–7.18(m, 4H), 7.30–7.52(m, 6H) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 13 
               
               
                   
               
             
            
               
                 I-1 
                 m.p. 155.5–156° C. 
               
               
                   
                   1 HNMR(acetone-d 6 ) δ 1.77(brs, 3H), 1.79(brs, 3H), 3.37(s, 3H), 3.73(s, 3H), 4.63(brd, J=6.6Hz, 2H), 5.52(m, 1H), 6.49(1H, s), 6.83(d 
               
               
                   
                 d, J=2.2 and 8.2Hz, 1H), 6.92(d, J=2.2Hz, 1H), 6.94(m, 2H), 6.96(d, J=8.2Hz, 1H), 7.54(m, 2H), 7.62(brs, 1H), 7.78(s, 1H), 8.64(brs, 1H) 
               
               
                   
                 IR(KBr)3393, 2932, 1611, 1588, 1522, 1490, 1117, 1071, 1001cI-3 m −1   
               
               
                 I-2 
                   1 HNMR(CDCl 3 ) δ 2.67(s, 3H), 3.13(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H ), 5.19(s, 2H), 6.84(s, 1H), 7.15(d, J=8.6Hz, 1H), 7.30–7.50 
               
               
                   
                 (m, 9H), 7.60–7.75(m, 2H) 
               
               
                   
                 IR(KBr)1373, 1361, 1179, 1149, 1079, 874, 799cm −1   
               
               
                 I-3 
                 m.p. 155–157° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.43–5.55 
               
               
                   
                 (m, 1H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.30–7.42(m, 4H), 7.65–7.75(m, 2H) 
               
               
                   
                 IR(KBr)1519, 1481, 1364, 1179, 1153, 1083, 970, 877, 796cm −1   
               
               
                 I-4 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 5.16(s, 2H), 6.44(s, 1H), 6.92–7.19(m, 5H), 7.34–7.44(m, 5H), 7.57–7.66(m, 2H) 
               
               
                   
                 IR(KBr)3538, 3510, 3460, 3330, 1605, 1521, 1490, 1455, 1247, 1220, 1120, 1070, 1010cm −1   
               
               
                 I-5 
                 m.p. 136–138° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.68(s, 3H), 3.13(s, 3H), 3.55(s, 3H), 3.80(s, 3H)5.19(s, 2H), 6.86(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.33–7.49(m, 7H), 7.55–7.69 
               
               
                   
                 (m, 2H), 7.82–7.87(m, 2H) 
               
               
                   
                 IR(KBr)3433, 2937, 1609, 1519, 1474, 1463, 1364, 1322, 1295, 1274, 1235, 1183, 1167, 1120, 1095, 1077, 1016cm −1   
               
               
                 I-6 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.72(s, 3H), 3.24(s, 3H), 3.49(s, 3H), 3.80(s, 3H), 4.64(d, J=6.9Hz, 2H), 5.50(m, 1H), 6.86(s, 
               
               
                   
                 1H), 7.10(d, J=8.7Hz, 1H), 7.35(dd, J=2.1, 8.7Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.55–7.69(m, 2H), 7.82–7.87(m, 2H). 
               
               
                   
                 IR(CHCl 3 )3030, 1608, 1518, 1480, 1369, 1322, 1269, 1230, 1179, 1131, 1120, 1097, 1081, 1015cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 14 
               
               
                   
               
             
            
               
                 I-7 
                 m.p. 92–94° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.77(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.31(m, 1H), 5.71(s, 1H), 5.85(s, 1H), 6.47(s, 
               
               
                   
                 1H), 6.93(dd, J=1.8, 8.7Hz, 1H), 6.97(d, J=8.7Hz, 1H), 7.05(d, J=1.8Hz, 1H), 7.55–7.65(m, 2H), 7.83–7.91(m, 2H). 
               
               
                   
                 IR(KBr)3466, 2939, 1609, 1587, 1518, 1498, 1486, 1464, 1437, 1406, 1361, 1324, 1245, 1216, 1155, 1125, 1073cm −1   
               
               
                 I-8 
                   1 HNMR(CDCl 3 ) δ 3.22(s, 3H), 3.45(s, 3H), 3.77(s, 3H), 4.74(s, 2H), 5.15(s, 2H), 6.93(s, 1H), 7.01(d, J=8.7Hz, 2H), 7.32–7.48(m, 9H), 7.73 
               
               
                   
                 (d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3400, 1721, 1612, 1509, 1471, 1362, 1242, 1153, 1040, 1018cm −1   
               
               
                 I-9 
                   1 HNMR(CDCl 3 ) δ 1.03(t, J=7.2Hz, 3H), 2.16(dq, J=7.2, 6.0Hz, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.68(d, J=5.4Hz, 2H), 5.70(m, 2H), 6.45 
               
               
                   
                 (s, 1H), 6.91(d, J=8.7Hz, 2H), 6.96(brs, 2H), 7.07(brs, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3445, 3369, 1612, 1578, 1523, 1489, 1268, 1243, 1112, 1102, 1071, 1011, 998, 944, 824, 805, 781cm −1   
               
               
                 I-10 
                 m.p. 174–175° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.11(s, 3H), 3.21(s, 3H), 3.45(s, 3H), 3.73(s, 3H), 4.49(brs, 2H), 5.18(s, 2H), 6.85(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.27 
               
               
                   
                 (dd, J=8.4Hz, J=2.1Hz, 1H), 7.35–7.49(m, 8H), 7.70(m, 2H) 
               
               
                   
                 IR(KBr)1519, 1467, 1360, 1346, 1331, 1295, 1272, 1229, 1180, 1151, 1122, 1101, 1081, 1022, 980, 971, 954, 875, 849, 814, 798, 742, 525cm −1   
               
               
                 I-11 
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 3.22(s, 6H), 3.45(s, 3H), 3.74(s, 3H), 4.49(brs, 2H), 4.64(d, J=7.2Hz, 2H), 5.45–5.55(m, 1H), 
               
               
                   
                 6.85(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.26(dd, J=8.7 and 2.1Hz, 1H), 7.33(d, J=2.1Hz, 1H), 7.36–7.41(m, 2H), 7.65–7.75(m, 2H) 
               
               
                   
                 IR(KBr)3553, 3434, 1516, 1472, 1365, 1176, 1150, 973, 871cm −1   
               
               
                 I-12 
                   1 HNMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.77(s, 3H), 3.35(s, 3H), 3.65(s, 3H), 4.20(brs, 2H), 4.47(brt, J=4.4Hz, 1H), 4.55(brd, J=6.6Hz, 2H), 
               
               
                   
                 5.40–5.57(m, 1H), 6.64(dd, J=8.2, 2.0Hz, 1H), 6.70(d, J=2.0Hz, 1H), 6.75–7.00(m, 4H), 7.40–7.55(m, 2H) 
               
               
                   
                 IR(KBr)3435, 1518, 1475, 1459, 1261, 1223, 988cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 15 
               
               
                   
               
             
            
               
                 I-13 
                   1 HNMR(CDCl 3 ) δ 2.71(s, 3H), 2.84(s, 3H), 3.20(s, 3H), 3.42(s, 3H), 3.76(s, 3H), 5.13(s, 2H), 5.67(s, 1H), 6.90(s, 1H), 6.89–6.96(m, 2H), 
               
               
                   
                 7.00(m, J=1.8Hz, 1H), 7.32–7.50(m, 7H), 7.70(d, J=9.0Hz, 2H) 
               
               
                 I-14 
                 m.p. 140–141° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.71(s, 3H), 2.83(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.42(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 6.90(s, 1H), 7.09(d, J=8.9Hz, 
               
               
                   
                 2H), 7.30–7.50(m, 9H), 7.70(d, J=8.9Hz, 2H) 
               
               
                   
                 IR(KBr)1642, 1516, 1467, 1362, 1180, 1151, 1118, 1050, 867, 803, 708cm −1   
               
               
                 I-15 
                 m.p. 161–162° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.72(s, 3H), 2.85(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.42(s, 3H), 3.77(s, 3H), 4.61(d, J=6.6Hz, 
               
               
                   
                 2H), 5.49(t, J=6.6Hz, 1H), 6.90(S, 1H), 7.02(d, J=8.1Hz, 1H), 7.31–7.37(m, 2H), 7.38(d, J=8.9Hz, 2H), 7.70(d, J=8.9Hz, 2H) 
               
               
                   
                 IR(KBr)1643, 1516, 1467, 1362, 1277, 1236, 1180, 1150, 974, 882, 868, 847, 802, 710cm −1   
               
               
                 I-16 
                 m.p. 206–207° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.71(s, 3H), 1.76(s, 3H), 2.62(s, 3H), 2.69(s, 3H), 3.27(s, 3H), 3.71(s, 3H), 4.53(d, J=6.8Hz, 2H), 5.47(t, J=6.6Hz, 1H), 
               
               
                   
                 6.61(dd, J=8.3 and 2.1Hz, 1H), 6.71(d, J=2.1Hz, 1H), 6.86(d, J=8.7Hz, 2H), 6.87(d, J=8.3Hz, 1H), 6.95(s, 1H), 7.47(d, J=8.7Hz, 2H), 8.83 
               
               
                   
                 (brs, 1H), 9.59(brs, 1H) 
               
               
                   
                 IR(KBr)3427, 3020, 1608, 1517, 1467, 1379, 1233, 1053, 1005, 839, 799, 759, 543cm −1   
               
               
                 I-17 
                 m.p. 171–172° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.74(d, J=0.9Hz, 3H), 1.77(s, 3H), 2.97(s, 3H), 3.45(s, 3H), 3.51(s, 3H), 3.77(s, 3H), 4.65(d, J=6.6Hz, 2H), 5.48 
               
               
                   
                 (m, 1H), 7.06–7.27(m, 4H), 7.48&amp;7.74(ABq, J=9.0Hz, 4H) 
               
               
                   
                 IR(KBr)1523, 1483, 1394, 1366, 1271, 1175, 1151, 1087, 1071, 872, 861, 847, 796cm −1   
               
               
                 I-18 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(s, 3H), 3.44(s, 3H), 3.76(s, 3H), 4.63(d, J=6.6Hz, 2H), 4.99(s, 1H), 5.48–5.62(m, 1H), 6.00(s, 1H), 6.45 
               
               
                   
                 (s, 1H), 6.88–6.97(m, 2H), 7.04(dd, J=9.0, 9.0Hz, 1H), 7.15–7.29(m, 2H), 7.45–7.60(m, 2H) 
               
               
                   
                 IR(KBr)3393, 1523, 1490, 1466, 1403, 1267, 1229, 1113, 1070cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 16 
               
               
                   
               
             
            
               
                 I-19 
                   1 HNMR(CDCl 3 ) δ 2.56(s, 3H), 3.21(s, 3H), 3.52(s, 3H), 3.69(s, 3H), 5.19(s, 2H), 5.76(s, 1H), 6.92(dd, J=8.4 and 2.0Hz, 1H), 7.04(d, J=8.4Hz, 
               
               
                   
                 1H), 7.05(d, J=2.0Hz, 1H), 7.35–7.51(m, 7H), 7.60(d, J=8.6Hz, 2H) 
               
               
                 I-20 
                   1 HNMR(CDCl 3 ) δ 2.69(s, 3H), 3.14(s, 3H), 3.21(s, 3H), 3.53(s, 3H), 3.71(s, 3H), 5.20(s, 2H), 7.18(d, J=8.7Hz, 1H), 7.34–7.50(m, 9H), 7.59 
               
               
                   
                 (d, J=8.71Hz, 2H) 
               
               
                 I-21 
                 m.p. 94–95° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.73(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.53(s, 3H), 3.71(s, 3H), 4.65(d, J=6.9Hz, 2H), 5.50(t, J=6.9Hz, 1H), 7.12(d, J=8.6Hz, 
               
               
                   
                 1H), 7.36(dd, J=8.6 and 2.1Hz, 1H), 7.41(d, J=2.1Hz, 2H), 7.41(d, J=8.8Hz, 2H), 7.59(d, J=8.8Hz, 2H) 
               
               
                   
                 IR(KBr)1516, 1367, 1180, 1152, 1039, 975, 869, 799cm −1   
               
               
                 I-22 
                 m.p. 148–150° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.42(s, 3H), 3.65(s, 3H), 4.63(d, J=6.9Hz, 2H), 4.98(brs, 1H), 5.53(t, J=6.9Hz, 1H), 6.92–6.96(m, 4H), 7.07(s, 1H), 7.43 
               
               
                   
                 (d, J=8.6Hz, 2H) 
               
               
                   
                 IR(KBr)3398, 1612, 1587, 1523, 1462, 1410, 1261, 1211, 1099, 1036, 984, 952, 919, 838, 815cm −1   
               
               
                 I-23 
                   1 HNMR(CDCl 3 ) δ 2.28(t, J=6.3Hz, 1H), 2.60(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.78(d, J=6.3Hz, 2H), 5.18(s, 2H), 6.84(s, 1H), 
               
               
                   
                 7.06(d, J=9.0Hz, 1H), 7.29–7.48(m, 9H), 7.69(d, J=8.7Hz, 2H) 
               
               
                 I-24 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.26(s, 3H), 2.50(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 4.57(d, J=6.2Hz, 2H), 5.51(t, 
               
               
                   
                 J=6.2Hz, 1H), 6.83(s, 1H), 6.92(d, J=9.0Hz, 1H), 7.17–7.29(m, 2H), 7.36(d, J=8.7Hz, 2H), 7.70(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3434, 1608, 1512, 1479, 1364, 1234, 1175, 1150, 1078, 1017cm −1   
               
               
                 I-25 
                   1 HNMR(CDCl 3 ) δ 1.75(s, 3H), 1.80(s, 3H), 2.27(s, 3H), 3.46(s, 3H), 3.74(s, 3H), 4.57(d, J=6.2Hz, 2H), 4.95(s, 1H), 5.53(t, J=6.2Hz, 1H), 
               
               
                   
                 5.86(s, 1H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.92(d, J=9.0Hz, 1H), 7.24(d, J=9.0Hz, 1H), 7.26(s, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3399, 1612, 1566, 1581, 1520, 1486, 1237, 1115, 1078, 1001cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 17 
               
               
                   
               
             
            
               
                 I-26 
                 m.p. 246–247° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 5.16(s, 3H), 6.84–6.87(m, 2H), 7.05(s, 2H), 7.14(s, 1H), 7.32–7.43(m, 3H), 7.49–7.64(m, 8H) 
               
               
                   
                 IR(KBr)3600–3100(br), 1594, 1453, 1387, 1296, 1253, 1010cm −1   
               
               
                 I-27 
                   1 HNMR(DMSO-d 6 ) δ 3.38(s, 3H), 3.43(s, 3H), 5.28(s, 2H), 7.36–7.54(m, 8H), 7.69–7.86(m, 8H) 
               
               
                   
                 IR(KBr)1488, 1354, 1286, 1178, 1151, 1116cm −1   
               
               
                 I-28 
                 m.p. 162–163° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 3.19(s, 3H), 3.23(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.25–5.48(m, 1H), 7.09(d, J=9.0Hz, 1H), 7.36–7.40 
               
               
                   
                 (m, 2H), 7.52(dd, J=2.4, 9.0Hz, 1H), 7.59(d, J=2.4Hz, 1H), 7.62(s, 4H), 7.63–7.69(m, 2H) 
               
               
                   
                 IR(KBr)1489, 1363, 1290, 1177, 1154, 1115, 971, 860, 809cm −1   
               
               
                 I-29 
                 m.p. 195° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.75(s, 3H), 4.57(d, J=6.3Hz, 2H), 5.45–5.50(m, 1H), 6.84–6.87(m, 2H), 6.98–7.11(m, 3H), 7.50–7.64 
               
               
                   
                 (m, 6H) 
               
               
                   
                 IR(KBr)3600–3200(br), 1609, 1594, 1497, 1257, 991cm −1   
               
               
                 I-30 
                 m.p. 145–148° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.60–2.20(m, 6H), 2.72(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.92(m, 1H), 5.88(m, 1H), 6.02(m, 1H), 
               
               
                   
                 6.84(s, 1H), 7.12(d, J=8.6Hz, 1H), 7.34–7.40(m, 4H), 7.69(m, 2H) 
               
               
                   
                 IR(KBr)1517, 1481, 1390, 1362, 1270, 1244, 1180, 1151, 1077, 1012, 973, 960, 873, 817, 799, 521cm −1   
               
               
                 I-31 
                 m.p. 108–110° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.60–2.20(m, 6H), 3.46(s, 3H), 3.75(s, 3H), 4.86(m, 1H), 5.02(bs, 1H), 5.75(s, 1H), 5.90(m, 1H), 5.91(s, 1H), 6.00(m, 1H), 
               
               
                   
                 6.45(s, 1H), 6.90–7.07(m, 5H), 7.53(m, 2H) 
               
               
                   
                 IR(KBr)3485, 1614, 1523, 1491, 1457, 1407, 1312, 1287, 1269, 1238, 1195, 1170, 1115, 1072, 1014cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 18 
               
               
                   
               
             
            
               
                 I-32 
                 m.p. 188–190° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.69(s, 3H), 3.21(s, 3H), 3.26(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.84(m, 2H), 6.42(dt, J=15.6Hz, J=5.7Hz, 1H), 6.79(d, 
               
               
                   
                 J=15.6Hz, 1H), 6.84(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.28–7.43(m, 9H), 7.68(m, 2H) 
               
               
                   
                 IR(KBr)1519, 1479, 1447, 1391, 1360, 1301, 1273, 1241, 1228, 1201, 1175, 1152, 1120, 1079, 1014, 974, 959, 947, 868, 819, 795, 777, 743, 
               
               
                   
                 521cm −1   
               
               
                 I-33 
                 m.p. 157–159° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.46(s, 3H), 3.75(s, 3H), 4.81(m, 2H), 4.93(bs, 1H), 5.70(s, 1H), 5.91(s, 1H), 6.45(s, 1H), 6.46(dt, J=15.9Hz, J=6.0Hz, 
               
               
                   
                 1H), 6.76(d, J=15.9Hz, 1H), 6.90–7.09(m, 5H), 7.26–7.46(m, 5H), 7.54(m, 2H) 
               
               
                   
                 IR(KBr)3466, 1611, 1522, 1489, 1461, 284, 1248, 1192, 1165, 1114, 1073cm −1   
               
               
                 I-34 
                 m.p. 127–129° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.03 and 1.04(botht, bothJ=8.0Hz, total3H), 2.07–2.19(m, 2H), 2.71 and 2.72(boths, total3H), 3.21(s, 3H), 3.24(s, 
               
               
                   
                 3H), 3.56(s, 3H), 3.78(s, 3H), 4.60 and 4.71(bothm, total2H), 5.66–5.75 and 5.90–5.99(bothm, total2H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 
               
               
                   
                 7.33–7.41(m, 4H), 7.68(m, 2H) 
               
               
                   
                 IR(KBr)1519, 1482, 1390, 1362, 1232, 1180, 1150, 1077, 974, 873, 815, 799, 522cm −1   
               
               
                 I-35 
                 m.p. 166–168° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.04 and 1.05(botht, bothJ=7.5Hz, total3H), 2.09–2.19(m, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.58 and 4.68(bothm, total2H), 
               
               
                   
                 5.01(bs, 1H), 5.69–5.78 and 5.87–5.95(bothm, total4H), 6.45(s, 1H), 6.90–7.06(m, 5H), 7.53(m, 2H) 
               
               
                   
                 IR(KBr)3531, 3489, 3306, 1523, 1492, 1459, 1408, 1314, 1287, 1270, 1255, 1234, 1224, 1118, 1072, 1018, 1005, 822cm −1   
               
               
                 I-36 
                 m.p. 148–150° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.62(s, 3H), 1.69(s, 3H), 1.76(s, 3H), 2.08–2.20(m, 4H), 2.71(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 
               
               
                   
                 4.66(d, J=6.3Hz, 2H), 5.09(m, 1H), 5.50(t, J=6.3Hz, 1H), 6.84(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.33–7.41(m, 4H), 7.68(m, 2H) 
               
               
                   
                 IR(KBr)1519, 1480, 1464, 1449, 1389, 1366, 1291, 1271, 1233, 1200, 1176, 1150, 1118, 1079, 1012, 973, 946, 876, 841, 816, 801, 523, 
               
               
                   
                 510cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 19 
               
               
                   
               
             
            
               
                 I-37 
                   1 HNMR(CDCl 3 ) δ 1.58(s, 3H), 1.63(s, 3H), 1.70(s, 3H), 2.05–2.20(m, 4H), 3.46(s, 3H), 3.75(s, 3H), 4.64(d, J=6.3Hz, 2H), 
               
               
                   
                 4.95(bs, 1H), 5.11(m, 1H), 5.53(m, 1H), 5.70(s, 1H), 5.90(s, 1H), 6.45(s, 1H), 6.91–7.08(m, 5H), 7.54(m, 2H) 
               
               
                 I-38 
                 m.p. 149–151° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.74(s, 3H), 2.55(m, 2H), 2.73(s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 4.07(t, 
               
               
                   
                 J=6.8Hz, 2H), 5.21(m, 1H), 6.84(s, 1H), 7.08(d, J=8.2Hz, 1H), 7.32–7.40(m, 4H), 7.68(m, 2H) 
               
               
                   
                 IR(KBr)1520, 1483, 1389, 1363, 1296, 1180, 1151, 1079, 975, 872, 815, 799, 521cm −1   
               
               
                 I-39 
                 m.p. 105–107° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.75(s, 3H), 2.53(m, 2H), 3.54(s, 3H), 3.74(s, 3H), 4.06(t, J=6.8Hz, 2H), 5.01(bs, 1H), 5.22(m, 1H), 
               
               
                   
                 5.69(s, 1H), 5.90(s, 1H), 6.45(s, 1H), 6.90–7.06(m, 5H), 7.53(m, 2H) 
               
               
                   
                 IR(KBr)3477, 3388, 1523, 1489, 1469, 1402, 1285, 1261, 1248, 1227, 1196, 1175, 1164, 1115, 1100, 1073, 1011cm −1   
               
               
                 I-40 
                 m.p. 155–157° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.89(t, J=2.4Hz, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.74(q, J=2.4Hz, 2H), 5.00(bs, 1H), 5.66(s, 1H), 5.92(s, 1H), 
               
               
                   
                 6.45(s, 1H), 6.90–7.08(m, 5H), 7.54(m, 2H) 
               
               
                   
                 IR(KBr)3446, 2224, 1523, 1488, 1402, 1266, 1238, 1203, 1187, 1166, 1102, 1068, 1009cm −1   
               
               
                 I-41 
                   1 HNMR(CDCl 3 ) δ 2.19(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.62(m, 2H), 4.92(bs, 1H), 5.60(bs, 1H), 5.92(s, 1H), 5.99(m, 1H), 
               
               
                   
                 6.45(m, 1H), 6.91–7.08(m, 5H), 7.53(m, 2H) 
               
               
                 I-42 
                 oil 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.87(s, 3H), 3.22(s, 6H), 3.55(s, 3H), 3.80(s, 3H), 4.66(d, J=7.5Hz, 2H), 5.61(m, 1H), 
               
               
                   
                 6.84(s, 1H), 7.37–7.41(m, 3H), 7.61(d, J=2.1Hz, 1H), 7.67(m, 2H) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 20 
               
               
                   
               
             
            
               
                 I-43 
                 m.p. 132–136° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.74(s, 3H), 1.82(s, 3H), 3.44(s, 3H), 3.76(s, 3H), 4.62(m, 2H), 5.05(brs, 1H), 5.61(m, 1H), 5.79(s, 1H), 6.02(s, 1H), 6.44 
               
               
                   
                 (s, 1H), 6.92(m, 2H), 7.04(d, J=2.1Hz, 1H), 7.20(d, J=2.1Hz, 1H), 7.53(m, 2H) 
               
               
                   
                 IR(KBr)3495, 3422, 1611, 1520, 1473, 1400, 1355, 1315, 1280, 1227, 1194, 1173, 1111, 1077, 1023cm −1   
               
               
                 I-44 
                 m.p. 148–149° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.60(s, 3H), 1.70(s, 3H), 2.32–2.39(m, 2H), 2.65(s, 3H), 2.76–2.81(m, 2H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78 
               
               
                   
                 (s, 3H), 5.16–5.21(m, 1H), 6.85(s, 1H), 7.30–7.40(m, 5H), 7.66–7.71(m, 2H) 
               
               
                   
                 IR(KBr)1480, 1390, 1361, 1181, 1150, 1075cm −1   
               
               
                 I-45 
                 m.p. 73–75° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.63(s, 3H), 1.72(s, 3H), 2.32–2.39(m, 2H), 2.64–2.70(m, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.83(s, 1H), 4.95(s, 1H), 5.27–5.31 
               
               
                   
                 (m, 1H), 5.92(s, 1H), 6.45(s, 1H), 6.89–7.00(m, 4H), 7.21(d, J=10.5Hz, 1H), 7.52–7.55(m, 2H) 
               
               
                   
                 IR(KBr)3600–3200(br), 3100–2800(br), 1612, 1579, 1523, 1487, 1452, 1400, 1360, 1226, 1174, 1111, 1072cm −1   
               
               
                 I-46 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 4.65(m, 2H), 4.85(s, 1H), 5.33(m, 1H), 5.44(m, 1H), 5.67(s, 1H), 5.91(s, 1H), 6.10(m, 1H), 6.45 
               
               
                   
                 (s, 1H), 6.92(m, 2H), 6.95(m, 2H), 7.08(m, 1H), 7.54(m, 2H) 
               
               
                 I-47 
                   1 HNMR(acetone-d 6 ) δ 3.39(s, 3H), 3.72(s, 3H), 5.20(s, 2H), 6.48(s, 1H), 6.83(dd, J=2.0Hz, J=8.4Hz, 1H), 6.93(m, 2H), 6.96(d, J=2.0Hz, 
               
               
                   
                 1H), 7.04(d, J=8.4Hz, 1H), 7.34–7.45(m, 3H), 7.52(m, 2H), 7.52–7.58(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3522, 3348, 1699, 1612, 1589, 1521, 1489, 1458, 1402, 1288, 1114, 1071, 935cm −1   
               
               
                 I-48 
                   1 HNMR(acetone-d 6 ) δ 1.28(t, J=7.2Hz, 3H), 3.39(s, 3H), 3.72(s, 3H), 4.25(q, J=7.2Hz, 2H), 4.78(s, 2H), 6.49(s, 1H), 6.83(dd, J=1.8 and 
               
               
                   
                 8.4Hz, 1H), 6.93(m, 2H), 6.96(d, J=1.8Hz, 1H), 6.97(d, J=8.4Hz, 1H), 7.52(m, 2H), 7.63(s, 1H), 7.83(s, 1H), 8.50(s, 1H) 
               
               
                 I-49 
                   1 HNMR(acetone-d 6 ) δ 1.75(m, 3H), 3.39(s, 3H), 3.72(s, 3H), 4.56(m, 2H), 5.71–5.82(m, 1H), 5.84–5.96(m, 1H), 6.48(s, 1H), 6.82(dd, J=2.0 
               
               
                   
                 and 8.4Hz, 1H), 6.93(d, J=2.0Hz, 1H), 6.93(m, 2H), 6.95(d, J=8.4Hz, 1H), 7.52(m, 2H) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 21 
               
               
                   
               
             
            
               
                 I-50 
                   1 HNMR(acetone-d 6 ) δ 1.75(m, 3H), 3.39(s, 3H), 3.72(s, 3H), 4.72(m, 2H), 5.73–5.75(m, 2H), 6.48(s, 1H), 6.83(dd, J=2.0 and 7.8Hz, 1H), 
               
               
                   
                 6.92–6.95(m, 3H), 6.97(d, J=7.8Hz, 1H), 7.52(m, 2H) 
               
               
                 I-51 
                   1 HNMR(acetone-d 6 ) δ 1.77(s, 3H), 1.79(s, 3H), 3.41(s, 3H), 3.72(s, 3H), 4.66(m, 2H), 5.53(m, 1H), 6.49(s, 1H), 6.85(m, 2H), 7.04(d, J=8.1Hz, 
               
               
                   
                 1H), 7.10(dd, J=2.1 and 8.1Hz, 1H), 7.19(d, J=2.1Hz, 1H), 7.25(m, 2H) 
               
               
                 I-52 
                   1 HNMR(CDCl 3 ) δ 2.58(t, J=2.2Hz, 1H), 2.73(s, 3H), 3.22(s, 3H), 3.26(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.83(d, J=2.2Hz, 2H), 6.85(s, 1H), 
               
               
                   
                 7.21(d, J=8.4Hz, 1H), 7.35–7.46(m, 4H), 7.64–7.74(m, 2H) 
               
               
                 I-53 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.76(s, 3H), 4.36(d, J=1.5Hz, 1H), 4.55(s, 2H), 4.76(dd, J=1.8 and 0.6Hz, 1H), 5.02(brs, 1H), 5.97(d, J=0.9Hz, 
               
               
                   
                 1H), 6.45(s, 1H), 6.90–6.96(m, 2H), 6.96–7.05(m, 2H), 7.10–7.12(m, 1H), 7.50–7.58(m, 2H 
               
               
                 I-54 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 2.61(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.61(d, J=6.9Hz, 2H), 5.17(brs, 1H), 5.45–5.50(m, 1H), 
               
               
                   
                 5.72(s, 1H), 6.84(s, 1H), 6.88–7.00(m, 4H), 7.02(d, J=1.8Hz, 1H), 7.50–7.57(m, 2H) 
               
               
                 I-55 
                   1 HNMR(CDCl 3 ) δ 0.99(d, J=6.5Hz, 6H), 1.74(q, J=6.5Hz, 2H), 1.85(m, 1H), 3.46(s, 3H), 3.75(s, 3H), 4.12(t, J=6.5Hz, 2H), 4.97(s, 1H), 
               
               
                   
                 5.65(s, 1H), 5.90(s, 1H), 6.45(s, 1H), 6.92(m, 2H), 6.95(m, 2H), 7.06(m, 1H), 7.54(m, 2H) 
               
               
                 I-56 
                   1 HNMR(CDCl 3 ) δ 1.34(s, 3H), 1.35(s, 3H), 3.15(dd, J=3.6 and 6.6Hz, 1H), 3.39(s, 3H), 3.72(s, 3H), 4.10(dd, J=6.6 and 11.1Hz and, 1H), 4.34 
               
               
                   
                 (dd, J=3.6 and 11.1Hz, 1H), 6.49(s, 1H), 6.83(dd, J=1.8 and 8.1Hz, 1H), 6.93(d, J=8.7Hz, 2H), 6.94(d, J=1.8Hz, 1H), 7.00(d, J=8.1Hz, 
               
               
                   
                 1H), 7.52(d, J=8.7Hz, 2H) 
               
               
                 I-57 
                   1 HNMR(CDCl 3 ) δ 2.68(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.83(s, 1H), 7.10–7.19(m, 3H), 7.31–7.50(m, 7H), 7.57–7.64 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(KBr)1607, 1520, 1481, 1373, 1231, 1176, 1119, 1078cm −1   
               
               
                 I-58 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 2.72(s, 3H), 3.23(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H), 
               
               
                   
                 6.84(t, J=6.6Hz, 1H), 5.83(s, 1H), 7.06–7.20(m, 3H), 7.31–7.40(m, 2H), 7.56–7.65(m, 2H) 
               
               
                   
                 IR(KBr)1603, 1521, 1483, 1376, 1366, 1176, 1085cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 22 
               
               
                   
               
             
            
               
                 I-59 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.52(t, J=6.9Hz, 1H), 5.71(brs, 1H), 5.89(s, 1H), 
               
               
                   
                 6.44(s, 1H), 6.90–7.19(m, 5H), 7.56–7.67(m, 2H) 
               
               
                   
                 IR(KBr)3545, 3385, 1605, 1586, 1561, 1520, 1384, 1311, 1284, 1225, 1121, 1096cm −1   
               
               
                 I-60 
                   1 HNMR(CDCl 3 ) δ 3.49(s, 3H), 3.74(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 5.91(s, 1H), 6.02(s, 2H), 6.43(s, 1H), 6.88–7.19(m, 6H), 7.31–7.48 
               
               
                   
                 (m, 5H) 
               
               
                   
                 IR(CHCl 3 )3535, 1615, 1588, 1519, 1500, 1482, 1410, 1290, 1241, 1204, 1092, 1041cm −1   
               
               
                 I-61 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.23(s, 3H), 3.57(s, 3H), 3.77(s, 3H), 4.64(d, J=6.6Hz, 1H), 5.50(t, J=6.6Hz, 1H), 6.03 
               
               
                   
                 (s, 2H), 6.83(s, 1H), 6.91(d, J=8.1Hz, 1H), 7.08(d, J=8.1Hz, 1H), 7.09(d, J=8.1Hz, 1H), 7.14(s, 1H), 7.34(d, J=8.1Hz, 1H), 7.39(s, 1H) 
               
               
                   
                 IR(CHCl 3 )1607, 1518, 1477, 1453, 1369, 1240, 1178, 1081cm −1   
               
               
                 I-62 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.49(s, 3H), 3.74(s, 3H), 4.61(d, J=6.9Hz, 2H), 5.53(t, J=6.9Hz, 1H), 5.68(s, 1H), 6.02(s, 2H), 
               
               
                   
                 6.43(s, 1H), 6.88–6.96(m, 3H), 7.03–7.18(m, 3H) 
               
               
                   
                 IR(KBr)3494, 1610, 1583, 1561, 1519, 1480, 1460, 1409, 1286, 1243, 1191, 1127, 1089, 1036cm −1   
               
               
                 I-63 
                 m.p. 201–202° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.78(s, 6H), 5.16(s, 4H), 5.69(s, 2H), 6.93(s, 2H), 6.99(d, J=8.4Hz, 2H), 7.08(dd, J=2.1 and 8.4Hz, 2H), 7.22(d, J=2.1Hz, 
               
               
                   
                 2H), 7.37–7.47(m, 10H), 
               
               
                   
                 IR(KBr)3600–3100(br), 1584, 1523, 1454, 1272, 1245, 1210, 1130cm −1   
               
               
                 I-64 
                 m.p. 173–175° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.12(s, 6H), 3.80(s, 6H), 5.18(s, 4H), 6.92(s, 2H), 7.12(d, J=8.7Hz, 2H), 7.36–7.50(m, 12H), 7.60(d, J=2.1Hz, 2H) 
               
               
                   
                 IR(KBr)1523, 1492, 1356, 1290, 1263, 1210, 1182, 1114cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 23 
               
               
                   
               
             
            
               
                 I-65 
                   1 HNMR(CDCl 3 ) δ 1.76(d, J=0.9Hz, 6H), 1.81(d, J=0.6Hz, 6H), 3.22(s, 6H), 3.80(s, 6H), 4.63(d, J=6.6Hz, 4H), 5.48–5.53(m, 2H), 6.92 
               
               
                   
                 (s, 2H), 7.05(d, J=8.4Hz, 2H), 7.48(dd, J=2.1 and 8.4Hz, 2H), 7.57(d, J=2.1Hz, 2H) 
               
               
                   
                 IR(KBr)1523, 1492, 1468, 1353, 1286, 1258, 1213, 1174, 1108cm −1   
               
               
                 I-66 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 6H), 1.82(s, 6H), 3.78(s, 6H), 4.62(d, J=6.9Hz, 4H), 5.50–5.55(m, 2H), 5.71(s, 2H), 6.91–6.94(m, 4H), 7.08(dd, 
               
               
                   
                 J=2.1 and 8.4Hz, 2H), 7.57(d, J=2.1Hz, 2H) 
               
               
                   
                 IR(KBr)3600–3200(br), 1523, 1492, 1271, 1242, 1210, 1186, 1034cm −1   
               
               
                 I-67 
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 3.22(s, 3H), 3.28(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.48–5.53(m, 1H), 6.92 
               
               
                   
                 (s, 1H), 6.93(s, 1H), 7.06(d, J=8.4Hz, 1H), 7.13(d, J=8.4Hz, 2H), 7.42–7.51(m, 3H), 7.57(d, J=21Hz, 1H) 
               
               
                   
                 IR(KBr)3600–3200(br), 1525, 1493, 1362, 1293, 1210, 1172, 1107cm −1   
               
               
                 I-68 
                 m.p. 168–169° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.18(s, 3H), 3.78(s, 3H), 3.79(s, 3H), 5.17(s, 2H), 5.71(s, 1H), 6.92(s, 1H), 6.96(s, 1H), 6.99(d, J=8.7Hz, 1H), 7.08(dd, J=2.1 
               
               
                   
                 and 8.7Hz, 1H), 7.24(d, J=2.1Hz, 1H), 7.26–7.48(m, 7H) 
               
               
                   
                 IR(KBr)3600–3200(br), 1488, 1382, 1369, 1269, 1206, 1174, 1146cm −1   
               
               
                 I-69 
                 m.p. 155–157° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.12(s, 3H), 3.19(s, 3H), 3.80(s, 6H), 5.18(s, 2H), 6.92(s, 1H), 6.95(s, 1H), 7.12(d, J=8.7Hz, 1H), 7.32–7.51(m, 8H), 
               
               
                   
                 7.60–7.65(m, 3H) 
               
               
                   
                 IR(KBr)1491, 1363, 1210, 1174, 1151, 1114cm −1   
               
               
                 I-70 
                 m.p. 109–110° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 3.19(s, 3H), 3.23(s, 3H), 3.80(s, 6H), 4.64(d, J=6.6Hz, 2H), 5.05–5.30(m, 1H), 6.92(s, 1H), 6.95 
               
               
                   
                 (s, 1H), 7.06(d, J=8.7Hz, 1H), 7.33–7.37(m, 2H), 7.49(dd, J=2.1 and 8.7Hz, 1H)7.58(d, J=2.1Hz, 1H), 7.61–7.64(m, 2H) 
               
               
                   
                 IR(KBr)1522, 1489, 1368, 1351, 1294, 1260, 1212, 1178, 1149, 1114, 975cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 24 
               
               
                   
               
             
            
               
                 I-71 
                   1 HNMR(CDCl 3 ) δ 1.72(s, 3H), 1.76(s, 3H), 3.72(s, 3H), 3.73(s, 3H), 4.56(d, J=6.6Hz, 2H), 5.46–5.49(brs, 1H), 6.79–6.82(m, 2H), 6.88–7.01 
               
               
                   
                 (m, 5H), 7.34–7.39(m, 2H), 8.89(s, 1H), 9.45(s, 1H) 
               
               
                   
                 IR(KBr)3600–3100(br), 1524, 1493, 1458, 1386, 1261, 1206, 1010cm −1   
               
               
                 I-72 
                 m.p. 123–124° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 3.19(s, 3H), 3.80(s, 6H), 4.64(d, J=6.9Hz, 2H), 5.52–5.57(m, 1H), 6.93(s, 1H), 6.94(s, 1H), 7.04 (t, 
               
               
                   
                 J=8.7Hz, 1H), 7.26–7.39(m, 3H), 7.60–7.65(m, 2H) 
               
               
                   
                 IR(KBr)1524, 1494, 1463, 1379, 1265, 1211, 1174, 1154, 1130cm −1   
               
               
                 I-73 
                 m.p. 118–119° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 4.63(d, J=6.9Hz, 2H), 4.86(s, 1H), 5.52–5.57(m, 1H), 6.88–6.93(m, 
               
               
                   
                 4H), 7.03(t, J=8.7Hz, 1H), 7.26–7.29(m, 1H), 7.37(dd, J=2.4 and 12.9Hz, 1H), 7.40–7.50(m, 2H) 
               
               
                   
                 IR(KBr)3600–3100(br), 1525, 1492, 1466, 1381, 1263, 1206cm −1   
               
               
                 I-74 
                   1 HNMR(CDCl 3 ) δ 2.63(s, 3H), 3.19(s, 3H), 5.18(s, 2H), 5.74(s, 1H), 7.03(d, J=8.4Hz, 1H), 7.07(dd, J=2.1 and 8.4Hz, 1H), 7.12(d, J=2.1Hz, 
               
               
                   
                 1H), 7.36–7.68(m, 12H) 
               
               
                   
                 IR(KBr)3700–3200(br), 1486, 1367, 1353, 1197, 1179, 1147cm −1   
               
               
                 I-75 
                   1 HNMR(CDCl 3 ) δ 2.80(s, 3H), 3.14(s, 3H), 3.19(s, 3H), 5.20(s, 2H), 7.18(d, J=8.4Hz, 1H), 7.38–7.68(m, 14H) 
               
               
                   
                 IR(KBr)1485, 1361, 1186, 1156, 1107cm −1   
               
               
                 I-76 
                   1 HNMR(CDCl 3 ) δ 1.78(s, 3H), 1.82(s, 3H), 2.81(s, 3H), 3.19(s, 3H), 3.26(s, 3H), 4.65(d, J=7.2Hz, 1H), 5.47–5.52(m, 1H), 7.11(d, J=8.7Hz, 
               
               
                   
                 1H), 7.37–7.67(m, 9H) 
               
               
                   
                 IR(KBr)1486, 1365, 1186, 1154, 1106, 973, 926, 870, 810cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 25 
               
               
                   
               
             
            
               
                 I-77 
                 m.p. 174–176° C. 
               
               
                   
                   1 HNMR(CDCl 3 ), δ 1.72(s, 3H), 1.76(s, 3H), 4.55(d, J=6.0Hz, 2H), 5.45–5.49(m, 1H), 6.82–7.43(m, 10H), 8.84(s, 1H), 9.45(s, 1H), 9.53(s, 1H) 
               
               
                   
                 IR(KBr)3600–3100(br), 1610, 1594, 1532, 1496, 1444, 1409, 1305, 1245, 1209cm −1   
               
               
                 I-78 
                 m.p. 134–135° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.78(s, 3H), 3.79(s, 3H), 5.17(s, 2H), 5.70(s, 1H), 6.91(s, 1H), 6.95(s, 1H), 6.99(d, J=8.4Hz, 1H), 7.07–7.14(m, 3H), 7.22 
               
               
                   
                 (d, J=2.1Hz, 1H), 7.36–7.47(m, 5H), 7.52–7.57(m, 2H) 
               
               
                   
                 IR(KBr)3600–3100(br), 1524, 1494, 1462, 1381, 1273, 1248, 1213cm −1   
               
               
                 I-79 
                   1 HNMR(CDCl 3 ) δ 3.12(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 5.18(s, 2H), 6.92(s, 1H), 6.94(s, 1H), 7.09–7.15(m, 3H), 7.38–7.56(m, 8H), 7.60 
               
               
                   
                 (d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr)1522, 1493, 1467, 1387, 1365, 1279, 1213, 1112cm −1   
               
               
                 I-80 
                 m.p. 110–111° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 3.22(s, 3H), 3.78(s, 3H), 3.80(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.50–5.57(m, 1H), 6.91(s, 1H), 6.94 
               
               
                   
                 (s, 1H), 7.04–7.14(m, 3H), 7.47–7.58(m, 4H) 
               
               
                   
                 IR(KBr)1552, 1493, 1364, 1212, 1110, 970cm −1   
               
               
                 I-81 
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 3.78(s, 3H), 3.79(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.50–5.55(m, 1H), 5.72(s, 1H), 6.91–6.95(m, 
               
               
                   
                 3H), 7.06–7.14(m, 3H), 7.20(d, J=1.8Hz, 1H), 7.52–7.57(m, 2H) 
               
               
                   
                 IR(KBr)3536, 1520, 1493, 1386, 1271, 1241, 1210cm −1   
               
               
                 I-82 
                   1 HNMR(CDCl 3 ) δ 1.29(t, J=7.2Hz, 3H), 1.76(s, 3H), 1.79(s, 3H), 3.78(s, 6H), 3.78(q, 2H), 4.64(d, J=6.3Hz, 2H), 4.72(s, 2H), 5.53–5.78 
               
               
                   
                 (m, 1H), 6.61(s, 1H), 6.94(s, 1H), 6.98(d, J=8.7Hz, 1H), 7.09–7.20(m, 4H), 7.52–7.57(m, 2H) 
               
               
                   
                 IR(KBr)1758, 1524, 1496, 1461, 1387, 1263, 1209, 1147cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 26 
               
               
                   
               
             
            
               
                 I-83 
                   1 HNMR(CDCl 3 ) δ 2.76(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 5.26(s, 2H), 6.85(s, 1H), 7.17(d, J=8.7Hz, 1H), 7.31–7.50(m, 8H), 
               
               
                   
                 7.60–7.71(m, 3H), 7.92(s, 1H) 
               
               
                   
                 IR(KBr)1684, 1606, 1512, 1478, 1177, 1150, 1080, 1016cm −1   
               
               
                 I-84 
                   1 HNMR(CDCl 3 ) δ 1.26(t, J=7.2Hz, 3H), 3.08(s, 3H), 3.22(s, 3H), 3.31(s, 3H), 3.74(s, 3H), 4.16(q, J=7.2Hz, 2H), 5.17(s, 2H), 6.44(d, J=16.5Hz, 
               
               
                   
                 1H), 6.89(s, 1H), 7.13(s, 2H), 7.27(d, J=8.4Hz, 1H), 7.35–7.50(m, 8H), 7.69(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1708, 1633, 1513, 1465, 1367, 1271, 1230, 1176, 1151, 1120, 1017cm −1   
               
               
                 I-85 
                   1 HNMR(CDCl 3 ) δ 1.26(t, J=7.2Hz, 3H), 3.22(s, 3H), 3.31(s, 3H), 3.74(s, 3H), 4.16(q, J=7.2Hz, 2H), 5.15(s, 2H), 5.70(s, 1H), 6.53(d, J=16.5Hz, 
               
               
                   
                 1H), 6.69(dd, J=8.4and2.4Hz, 1H), 6.88(s, 2H), 7.00(d, J=8.4Hz, 1H), 7.33–7.50(m, 8H), 7.70(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3398, 1675, 1627, 1581, 1512, 1465, 1370, 1284, 1256, 1221, 1148, 1074, 1017cm −1   
               
               
                 I-86 
                   1 HNMR(CDCl 3 ) δ 2.53(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 4.58(s, 2H), 5.24(s, 2H), 6.83(s, 1H), 6.96(d, J=8.4Hz, 1H), 7.28–7.57 
               
               
                   
                 (m, 9H), 7.69(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1605, 1512, 1479, 1366, 1233, 1175, 1149, 1080, 1015cm −1   
               
               
                 I-87 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 3.27(s, 3H), 3.78(s, 3H), 3.79(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.40–5.50(m, 1H), 5.71(s, 1H), 6.07 
               
               
                   
                 (s, 1H), 6.91–6.95(m, 3H), 7.05–7.20(m, 3H), 7.43–7.51(m, 2H) 
               
               
                   
                 IR(KBr)3600–3200(br), 1617, 1525, 1494, 1464, 1361, 1292, 1208, 1178, 1101, 1033cm −1   
               
               
                 I-88 
                   1 HNMR(CDCl 3 ) δ 2.57(s, 3H), 3.20(s, 3H), 3.56(s, 3H), 3.79(s, 3H), 5.18(s, 2H), 6.84(s, 1H), 7.06–7.15(m, 1H), 7.20–7.40(m, 9H), 7.47–7.57 
               
               
                   
                 (m, 2H), 7.60–7.75(m, 3H), 8.20–8.25(m, 2H) 
               
               
                 I-89 
                   1 HNMR(CDCl 3 ) δ 3.44(s, 3H), 3.75(s, 3H), 5.01(s, 1H), 5.18(s, 2H), 6.01(s, 1H), 6.45(s, 1H), 6.88–6.97(m, 2H), 7.07(dd, J=8.4and8.4Hz, 
               
               
                   
                 1H), 7.15–7.21(m, 1H), 7.27(dd, J=12.3 and 2.1Hz, 1H), 7.29–7.43(m, 3H), 7.45–7.56(m, 4H) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 27 
               
               
                   
               
             
            
               
                 I-90 
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.75(d, J=0.9Hz, 3H), 2.55(dt, J=6.9and6.9Hz, 2H), 2.70(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.04 
               
               
                   
                 (t, J=6.9Hz, 2H), 5.17–5.28(m, 1H), 6.84(s, 1H), 7.04(dd, J=8.4and8.4Hz, 1H), 7.11–7.22(m, 2H), 7.34–7.42(m, 2H), 7.65–7.75(m, 2H) 
               
               
                   
                 IR(KBr)1522, 1483, 1361, 1352, 1176, 1156, 1079, 963, 873, 801cm −1   
               
               
                 I-91 
                   1 HNMR(CDCl 3 ) δ 2.96(s, 3H), 3.52(s, 3H), 3.58(s, 6H), 3.73(s, 3H), 4.89(s, 2H), 5.19(s, 2H), 5.23(s, 2H), 5.25(s, 2H), 6.68(s, 1H), 6.98 
               
               
                   
                 (d, J=8.4Hz, 1H), 7.04(dd, J=8.4and2.1Hz, 1H), 7.11(m, 2H), 7.25(d, J=2.1Hz, 1H), 7.30–7.40(m, 5H), 7.51(m, 2H) 
               
               
                   
                 IR(KBr)2952, 2935, 2896, 1609, 1521, 1477, 1463, 1438, 1383, 1269, 1249, 1228, 1183, 1153, 1130, 1116, 1078, 1066, 1020, 1008, 984, 
               
               
                   
                 944, 922, 903, 832, 801, 730cm −1   
               
               
                 I-92 
                 mp 122–124° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.70(brs, 3H), 3.55–3.60(br, 2H), 3.60(s, 3H), 3.75(s, 3H), 3.81–3.83(m, 2H), 3.87(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 6.69 
               
               
                   
                 (s, 1H), 6.94(dd, J=2.1, 8.4Hz, 1H), 6.97–7.03(m, 3H), 7.07(d, J=1.8Hz, 1H), 7.38–7.48(m, 5H), 7.51–7.56(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1607, 1597, 1550, 1518, 1477, 1462, 1452, 1392, 1289, 1248, 1228, 1175, 1122, 1096, 1084, 1015cm −1   
               
               
                 I-93 
                   1 HNMR(CDCl 3 ) δ 2.59(dt, J=6.6, 6.6Hz, 2H), 3.45(s, 3H), 3.74(s, 3H), 4.15(t, J=6.6Hz, 2H), 5.15(dm, J=10.2Hz, 1H), 5.21(dm, J=17.1Hz, 1H), 
               
               
                   
                 5.90(m, 1H), 6.45(s, 1H), 6.92(d, J=8.4Hz, 2H), 6.95(s, 2H), 7.06(brs, 1H), 7.53(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(Nujol)3570, 3525, 3336, 3205, 1616, 1596, 1524, 1493, 1409, 1315, 1286, 1264, 1239, 1225, 1117, 1072, 821, 783cm −1   
               
               
                 I-94 
                   1 HNMR(CDCl 3 ) δ 0.36(m, 2H), 0.66(m, 2H), 1.31(m, 1H), 3.45(s, 3H), 3.74(s, 3H), 3.91(d, J=7.2Hz, 2H), 6.44(s, 1H), 6.91(d, J=8.7Hz, 
               
               
                   
                 2H), 6.93(m, 2H), 7.07(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3570, 3491, 3364, 3178, 1617, 1598, 1583, 1524, 1494, 1408, 1313, 1285, 1266, 1240, 1224, 1115, 1072, 1011, 822, 786cm −1   
               
               
                 I-95 
                   1 HNMR(CDCl 3 ) δ 1.86(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.54(s, 2H), 5.04(brs, 1H), 5.12(brs, 1H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.95 
               
               
                   
                 (m, 2H), 7.08(brs, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3536, 3364, 3179, 1614, 1586, 1524, 1493, 1407, 1309, 1284, 1265, 1238, 1226, 1115, 1073, 1011, 887, 821, 782cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 28 
               
               
                   
               
             
            
               
                 I-96 
                   1 HNMR(CDCl 3 ) δ 2.58(t, J=2.4Hz, 1H), 3.45(s, 3H), 3.74(s, 3H), 4.79(d, J=2.4Hz, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.98(dd, J=8.4, 
               
               
                   
                 2.1Hz, 1H), 7.07(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3410, 3282, 1612, 1589, 1523, 1489, 1404, 1226, 1114, 1071, 1015, 826cm −1   
               
               
                 I-97 
                   1 HNMR(CDCl 3 ) δ 2.71(s, 3H), 3.21(s, 3H), 3.38(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.47(s, 2H), 6.84(s, 1H), 7.00(d, J=8.6Hz, 1H), 7.34(dd, 
               
               
                   
                 J=8.6, 2.0Hz, 1H), 7.38(d, J=8.8Hz, 2H), 7.46(d, J=2.0Hz, 1H), 7.55(m, 2H), 7.67(m, 1H), 7.68(d, J=8.8Hz, 2H), 7.99(m, 2H) 
               
               
                 I-98 
                 m.p. 200–203° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 2.67(s, 3H), 3.12(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 5.14(s, 2H), 6.84(s, 1H), 7.15(d, J=8.7Hz, 
               
               
                   
                 1H), 7.21(d, J=8.1Hz, 2H), 7.34(d, J=8.1Hz, 2H), 7.34(dd, J=8.7, 2.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, J=2.4Hz, 1H), 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)1608, 1520, 1480, 1359, 1173, 1156, 1078, 1016, 976, 948, 872, 818, 791cm −1   
               
               
                 I-99 
                   1 HNMR(CDCl 3 ) δ 2.72(s, 3H), 3.13(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.15(s, 2H), 6.84(s, 1H), 7.09(d, J=8.7Hz, 1H), 7.12(dd, 
               
               
                   
                 J=8.7, 7.2Hz, 1H), 7.35(dd, J=8.7, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.45(dd, J=8.7, 5.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) 
               
               
                 I-100 
                   1 HNMR(CDCl 3 ) δ 2.76(s, 3H), 3.19(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.25(s, 2H), 6.85(s, 1H), 7.13(d, J=8.4Hz, 1H), 7.32(dd, 
               
               
                   
                 J=8.4, 1.8Hz, 1H), 7.36(dd, J=8.4, 1.8Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.42(d, J=1.8Hz, 1H), 7.45(d, J=1.8Hz, 1H), 7.59(d, J=8.4Hz, 1H), 
               
               
                   
                 7.68(d, J=8.7Hz, 2H) 
               
               
                 I-101 
                 m.p. 103–105° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.18(dd, J=1.5, 1.2Hz, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.79(dd, J=5.7, 1.2Hz, 2H), 5.81(dt, J=5.7, 1.5Hz, 2H), 6.45(s, 
               
               
                   
                 1H), 6.92(d, J=8.7Hz, 2H), 6.95(s, 1H), 6.96(s, 1H), 7.07(s, 1H), 7.52(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3527, 3328, 2930, 1614, 1593, 1523, 1492, 1463, 1408, 1262, 1235, 1225, 1119, 1072, 1010, 828, 805cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 29 
               
               
                   
               
             
            
               
                 I-102 
                 m.p. 95–99° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.74(s, 3H), 4.67(s, 2H), 5.47(m, 1H), 5.55(dd, J=2.7, 1.2Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 7.01 
               
               
                   
                 (m, 2H), 7.04(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                 I-103 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 4.59(d, J=4.2Hz, 2H), 6.45(s, 1H), 6.45(m, 1H), 6.55(d, J=12.9Hz, 1H), 6.92(d, J=8.7Hz, 2H), 
               
               
                   
                 6.96(brs, 2H), 7.08(brs, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                 I-104 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 4.64(dd, J=6.0and1.2Hz, 2H), 6.23(dt, J=13.2and6.0Hz, 1H), 6.42(dt, J=13.2and1.2Hz, 
               
               
                   
                 1H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.96(brs, 2H), 7.08(brs, 1H), 7.58(d, J=8.7Hz, 2H) 
               
               
                 I-105 
                   1 HNMR(CDCl 3 ) δ 3.46(s, 3H), 3.75(s, 3H), 3.98(d-like, J=7.2Hz, 1H), 4.64(d-like, J=3.9Hz, 1H), 6.04(dt, J=15.3, 4.8Hz, 1H), 6.06(1H, 
               
               
                   
                 dt, J=15.3, 6.0Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(s, 1H), 7.08(s, 2H), 7.53(d, J=8.7Hz, 2H) 
               
               
                 I-106 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.83(s, 3H), 2.08(s, 3H), 3.36(s, 3H), 3.71(s, 3H), 4.61(d, J=7.0Hz, 2H,), 4.94(s, 1H), 5.54(t, J=7.0Hz, 1H), 
               
               
                   
                 5.70(s, 1H), 6.70(dd, J=8.4, 2.0Hz, 1H), 6.74(s, 1H), 6.84(d, J=2.0Hz, 1H) 
               
               
                   
                 IR(KBr)3410, 1520, 1476, 1390, 1243, 1225, 1101, 1084, 834, 812, 775cm −1   
               
               
                 I-107 
                 m.p. 112–114° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.03(s, 3H), 3.57(s, 3H), 3.74(s, 3H), 3.87(s, 3H), 4.90(S, 2H), 5.15(s, 2H), 5.63(brs, 1H), 6.68(s, 1H), 6.91–7.07(m, 5H), 
               
               
                   
                 7.38–7.51(m, 5H), 7.53(m, 2H) 
               
               
                   
                 IR(KBr)3512, 2952, 2936, 1607, 1519, 1468, 1442, 1382, 1284, 1253, 1229, 1215, 1185, 1156, 1112, 1079, 1065, 1020, 983, 956, 914, 831cm −1   
               
               
                 I-108 
                   1 HNMR(CDCl 3 ) δ 2.20(d, J=1.2Hz, 3H), 2.76(s, 3H), 3.22(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.65(m, 2H), 5.96(m, 1H), 7.07 
               
               
                   
                 (d, J=8.4Hz, 1H), 7.34–7.41(m, 4H), 7.68(m, 2H) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 30 
               
               
                   
               
             
            
               
                 I-109 
                 m.p. 153–154° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.20(d, J=1.5Hz, 3H), 2.75(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.81(m, 2H), 5.80(m, 1H), 6.84( 
               
               
                   
                 s, 1H), 7.10(d, J=8.1Hz, 1H), 7.34–7.41(m, 4H), 7.68(m, 2H) 
               
               
                   
                 IR(KBr)1519, 1481, 1390, 1364, 1234, 1177, 1150, 1119, 1077, 1011, 969, 945, 876, 816, 799, 521cm −1   
               
               
                 I-110 
                   1 HNMR(CDCl 3 ) δ 2.68(s, 3H), 3.11(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 3.83(s, 3H), 5.11(s, 2H), 6.84(s, 1H), 6.93(d, J=8.7Hz, 
               
               
                   
                 2H), 7.16(d, J=8.7Hz, 1H), 7.35(dd, J=8.7, 2.1Hz, 1H), 7.36–7.40(m, 5H), 7.68(d, J=8.7Hz, 2H) 
               
               
                 I-111 
                   1 HNMR(CDCl 3 ) δ 2.78(s, 3H), 3.22(s, 6H), 3.55(s, 3H), 3.78(s, 3H), 5.23(s, 2H), 6.85(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.34(dd, J=8.7, 2.1Hz, 
               
               
                   
                 1H), 7.39(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H), 7.44(brs, 2H), 7.68(d, J=8.7Hz, 2H), 8.70(brs, 2H) 
               
               
                 I-112 
                   1 HNMR(CDCl 3 ) δ 2.70(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.33(s, 2H), 6.84(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.27(dd, 
               
               
                   
                 J=7.5, 4.2Hz, 1H), 7.33(dd, J=8.4, 2.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.42(d, J=2.4Hz, 1H), 7.62(brd, J=7.5Hz, 1H), 7.68(d, J=8.7Hz, 2H), 
               
               
                   
                 7.76(ddd, J=7.5, 7.5, 1.8Hz, 1H), 8.61(d, J=4.2Hz, 1H) 
               
               
                 I-113 
                   1 HNMR(CDCl 3 ) δ 2.76(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.22(s, 2H), 6.85(s, 1H), 7.17(d, J=8.4Hz, 1H), 7.38(dd, 
               
               
                   
                 J=8.4, 2.1Hz, 1H), 7.38(m, 1H), 7.39(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 7.88(d, J=7.8Hz, 1H), 7.64(brs, 1H), 
               
               
                   
                 8.73(brs, 1H) 
               
               
                 I-114 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.74(s, 3H), 5.10(s, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.95(dd, J=8.4, 2.1Hz, 1H), 7.03(d, J=8.4Hz, 
               
               
                   
                 1H), 7.08(d, J=2.1Hz, 1H), 7.23(brd, J=7.8Hz, 2H), 7.34(brd, J=7.8Hz, 2H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3464, 3344, 1611, 1581, 1523, 1490, 1266, 1113, 1073, 1011, 1000, 821, 782cm −1   
               
               
                 I-115 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 5.11(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(dd, J=8.4, 2.1Hz, 1H), 7.01(d, J=8.4Hz, 
               
               
                   
                 1H), 7.09(d, J=2.1Hz, 1H), 7.11(dd, J=8.7, 8.7Hz, 2H), 7.42(dd, J=8.7, 5.4Hz, 2H), 7.54(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3560, 3400, 1612, 1589, 1522, 1492, 1260.1225, 1116, 1068, 1006, 992, 841, 826, 803, 786cm  −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 31 
               
               
                   
               
             
            
               
                 I-116 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 5.23(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.97(brs, 2H), 7.11(brs, 1H), 7.31(dd, J=8.4, 
               
               
                   
                 2.1Hz, 1H), 7.46(d, J=8.4Hz, 1H), 7.47(d, J=2.1Hz, 1H), 7.54(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3460, 3359, 1610, 1594, 1522, 1490, 1264, 1164, 1110, 1072, 1008, 877, 824, 781cm −1   
               
               
                 I-117 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 3.84(s, 3H), 5.07(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(d, J=9.0Hz, 2H), 6.96(dd, J=8.4, 
               
               
                   
                 1.8Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.08(d, J=1.8Hz, 1H), 7.37(d, J=8.7Hz, 2H), 7.53(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(Nujol)3400, 1612, 1586, 1516, 1488, 1246, 1174, 1113, 1070, 1011, 823cm −1   
               
               
                 I-118 
                   1 HNMR(DMSO-d 6 ) δ 3.29(s, 3H), 3.64(s, 3H), 5.20(s, 2H), 6.39(s, 1H), 6.64(dd, J=8.4, 2.1Hz, 1H), 6.79(d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 
               
               
                   
                 2H), 6.92(d, J=8.4Hz, 1H), 7.43(d, J=8.7Hz, 2H), 7.52(d, J=6.0Hz, 2H), 8.59(d, J=6.0Hz, 2H) 
               
               
                   
                 IR(Nujol)3473, 3441, 1610, 1582, 1523, 1493, 1404, 1241, 1112, 1074, 1005, 816, 782cm −1   
               
               
                 I-119 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.74(s, 3H), 5.27(s, 2H), 6.45(s, 1H), 6.92(dd, J=8.4, 1.8Hz, 1H), 6.93(d, J=8.7Hz, 2H), 7.11(d, J=8.4Hz, 
               
               
                   
                 1H), 7.12(d, J=1.8Hz, 1H), 7.31(m, 1H), 7.36(brd, J=7.5Hz, 1H), 7.53(d, J=8.7Hz, 2H), 7.77(ddd, J=7.5, 7.5, 1.8Hz, 1H), 8.66(d, J=5.0Hz, 
               
               
                   
                 1H) 
               
               
                   
                 IR(Nujol)3555, 3467, 3342, 1608, 1597, 1586, 1522, 1466, 1210, 1117, 1080, 1016, 822, 761cm −1   
               
               
                 I-120 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.74(s, 3H), 5.21(s, 2H), 6.46(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.99(brs, 2H), 7.11(brs, 1H), 7.40(dd, J=7.5, 
               
               
                   
                 5.0Hz, 1H), 7.53(d, J=8.7Hz, 2H), 7.83(d, J=7.5Hz, 1H), 8.64(brd, J=5.0Hz, 1H), 8.74(brs, 1H) 
               
               
                   
                 IR(Nujol)3342, 1609, 1586, 1522, 1489, 1253, 1118, 1074, 1010, 827, 782cm −1   
               
               
                 I-121 
                 m.p. 166–168° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 4.77(d, J=6.3Hz, 2H), 6.22(t, J=6.3Hz, 1H), 6.93(d, J=8.7Hz, 2H), 6.93(d, J=8.7Hz, 1H), 6. 
               
               
                   
                 98(dd, J=8.7, 1.8Hz, 1H), 7.08(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3474, 3411, 2957, 2930, 1615, 1589, 1569, 1523, 1492, 1407, 1286, 1263, 1230, 1113, 1070, 825cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 32 
               
               
                   
               
             
            
               
                 I-122 
                 m.p. 190–192° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.56(s, 3H), 3.22(s, 3H), 3.56(s, 3H), 3.79(s, 3H), 5.17(s, 2H), 5.73(s, 1H), 6.84(s, 1H), 6.93(dd, J=8.1 and 1.9Hz, 1H), 
               
               
                   
                 7.02(d, J=8.1Hz, 1H), 7.05(d, J=1.9Hz, 1H), 7.37–7.45(m, 1H), 7.71(d, J=8.6Hz, 2H) 
               
               
                   
                 IR(KBr)3512, 1519, 1484, 1367, 1174, 1150, 1078, 957, 870, 798cm −1   
               
               
                 I-123 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.08(s, 3H), 3.21(s, 3H), 3.44(s, 3H), 3.78(s, 3H), 5.15(s, 2H), 6.95(s, 1H), 7.11(d, J=8.7Hz, 1H), 7.33–7.47(m, 9H), 7.71 
               
               
                   
                 (d, J=8.7Hz, 2H), 13.3–14.5(brs, 1H) 
               
               
                   
                 IR(KBr): 3422, 1735, 1702, 1520, 1471, 1366, 1175, 1150, 1118, 971, 954, 863, 807cm −1   
               
               
                 I-124 
                 m.p. 258–259° C. (dec) 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.32(s, 3H), 3.69(s, 3H), 5.10(2H, s), 6.65(dd, J=8.4, 2.1Hz, 1H), 6.79(d, J=2.1Hz, 1H), 6.86(d, J=8.4Hz, 2H), 6.90 
               
               
                   
                 (s, 1H), 6.94(d, J=8.4Hz, 1H), 7.30–7.54(m, 7H), 8.98(s, 1H), 9.63(s, 1H) 
               
               
                   
                 IR(KBr): 3437, 3157, 1702, 1610, 1590, 1521, 1474, 1464, 1379, 1260, 1245, 1224, 1061, 1014, 952, 834, 793, 748, 698cm −1   
               
               
                 I-125 
                   1 HNMR(CDCl 3 ) δ 1.75(s, 3H), 1.81(s, 3H), 3.21(s, 3H), 3.41(s, 3H), 3.68(s, 3H), 3.77(s, 3H), 4.61(d, J=6.8Hz, 2H), 5.50(t, J=6.8Hz, 1H), 
               
               
                   
                 6.93(s, 1H), 7.02(d, J=8.5Hz, 1H), 7.27(d, J=8.5, 2.3Hz, 1H), 7.33(dd, J=2.3Hz, 1H), 7.38(d, J=8.6Hz, 2H), 7.71(d, J=8.6Hz, 2H) 
               
               
                 I-126 
                   1 HNMR(CDCl 3 ) δ 1.75(s, 3H), 1.81(s, 3H), 3.41(s, 3H), 3.65(s, 3H), 3.76(s, 3H), 4.59(d, J=6.6Hz, 2H), 5.06(s, 1H), 5.51(t, J=6.6Hz, 1H), 
               
               
                   
                 5.67(s, 1H), 6.83(dd, J=8.4, 2.1Hz, 1H), 6.87(s, 1H), 6.90–6.93(m, 3H), 6.98(d, J=2.1Hz, 1H), 7.54(d, J=9.0Hz, 2H) 
               
               
                 I-127 
                 m.p. 116–117° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.76(s, 3H), 3.32(s, 3H), 3.70(s, 3H), 4.53(d, J=7.1Hz, 2H), 5.48(t, J=7.1Hz, 1H), 6.65(dd, J=8.4, 2.1Hz, 
               
               
                   
                 1H), 6.73(d, J=2.1Hz, 1H), 6.86(d, J=8.6Hz, 2H), 6.88(d, J=8.4Hz, 1H), 6.93(s, 1H), 7.47(d, J=8.6Hz, 2H), 8.84(s, 1H), 9.62(s, 1H), 11.9–13.4 
               
               
                   
                 (brs, 1H) 
               
               
                   
                 IR(KBr): 3446, 1703, 1611, 1593, 1520, 1471, 1380, 1260, 1225, 1081, 997, 952, 838cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 33 
               
               
                   
               
             
            
               
                 I-128 
                 oil 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.65(s, 3H), 1.78(s, 3H), 2.96(s, 3H), 3.22(s, 3H), 3.25(s, 3H)3.55(s, 3H), 3.79(s, 3H), 4.77(d, J=7.8Hz, 2H), 5.53(t, J=7.8Hz, 
               
               
                   
                 1H), 6.87(s, 1H), 7.39&amp;7.67(ABq, J=8.7Hz, 4H), 7.70(d, J=2.1Hz, 1H), 7.86(d, J=2.1Hz, 1H), 10.36(s, 1H) 
               
               
                   
                 IR(CHCl 3 )1691, 1473, 1374, 1230, 1226, 1209, 1178, 1152, 1086, 969, 874, 805cm −1   
               
               
                 I-129 
                 oil 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.73(d, J=0.9Hz, 3H), 1.80(s, 3H), 2.89(s, 3H), 3.20(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 4.66(d, J=7.8Hz, 2H), 
               
               
                   
                 4.77(s, 2H), 5.55(m, 1H), 6.85(s, 1H), 7.39&amp;7.68(ABq, J=9.0Hz, 4H), 7.39(d, J=2.1Hz, 1H), 7.44(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )1475, 1372, 1230, 1178, 1151, 1085, 969, 874cm −1   
               
               
                 I-130 
                 m.p. 189–190° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.36(s, 9H), 2.81(s, 3H), 3.22(s, 3H), 3.30(s, 3H), 3.56(s, 3H), 3.79(s, 3H), 6.86(s, 1H), 7.36–7.42(m, 3H), 7.54(d, J=1.8Hz, 
               
               
                   
                 1H), 7.67–7.72(m, 3H) 
               
               
                   
                 IR(KBr)1472, 1363, 1331, 1179, 1153, 1082, 961, 950, 877, 846, 817, 791, 526cm −1   
               
               
                 I-131 
                 m.p. 147–148° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.95(s, 3H), 3.18(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 5.28(s, 2H), 6.86(s, 1H), 7.38–7.44(m, 7H), 7.67(m, 2H), 
               
               
                   
                 7.75(d, J=2.1Hz, 1H), 7.83(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr) 1687, 1512, 1472, 1365, 1352, 1234, 1201, 1180, 1151, 1082, 971, 947, 870, 846, 810, 794, 703, 523cm −1   
               
               
                 I-132 
                 m.p. 122–124° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.74(s, 3H), 2.80(s, 3H), 3.22(s, 3H), 3.28(s, 3H), 3.56(s, 3H), 3.62(d, J=7.8Hz, 2H), 3.78(s, 3H), 5.31(m, 
               
               
                   
                 1H), 6.85(s, 1H), 7.34(dd, J=8.1Hz, J=1.8Hz, 1H), 7.39&amp;7.68(ABq, J=8.7Hz, 4H), 7.43(d, J=8.1Hz, 1H), 7.46(d, J=1.8Hz, 1H) 
               
               
                   
                 IR(KBr) 1474, 1362, 1180, 1151, 1076, 1014, 968, 944, 870, 816, 799, 521cm −1   
               
               
                 I-133 
                   1 HNMR(CDCl 3 ) δ 1.73(d, J=0.9Hz, 3H), 1.82(s, 3H), 3.44(s, 3H), 3.75(s, 3H), 4.54(d, J=6.9Hz, 2H), 4.78(s, 2H), 5.30(s, 1H), 5.61(m, 1H), 
               
               
                   
                 5.67(s, 1H), 6.01(s, 1H), 6.45(s, 1H), 6.92&amp;7.52(ABq, J=8.7Hz, 4H), 7.02(d, J=2.1Hz, 1H), 7.05(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr)3428, 1612, 1522, 1483, 1458, 1403, 1362, 1334, 1304, 1266, 1226, 1174, 1116, 1083, 1024, 970, 938cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 34 
               
               
                   
               
             
            
               
                 I-134 
                 m.p. 167–168° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.39(d, J=1.2Hz, 3H), 1.70(s, 3H), 3.36(d, J=8.1Hz, 2H), 3.45(s, 3H), 3.74(s, 3H), 4.98(s, 1H), 5.29(m, 1H), 5.96(s, 1H), 
               
               
                   
                 6.45(s, 1H), 6.78(s, 1H), 6.93&amp;7.54(ABq, J=8.7Hz, 4H), 6.96(dd, J=7.8Hz, J=1.8Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.49(d, J=7.8Hz, 1H) 
               
               
                   
                 IR(KBr)3413, 3365, 2931, 1611, 1552, 1520, 1502, 1475, 1455, 1441, 1402, 1360, 1323, 1262, 1227, 1206, 1182, 1170, 1162, 1114, 1100, 
               
               
                   
                 1081, 1052, 1014, 941, 835, 816, 587, 542cm −1   
               
               
                 I-135 
                 m.p. 183–184° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.46(s, 3H), 3.74(s, 3H), 3.83(s, 3H), 4.78(m, 2H), 5.99(m, 1H), 6.44(m, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.94( 
               
               
                   
                 dd, J=8.1, 1.8Hz, 1H), 7.00(d, J=8.1Hz, 1H), 7.10(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3383, 2929, 1699, 1523, 1491, 1405, 1262, 1236, 1206, 1173, 1116, 1071, 1011, 822cm −1   
               
               
                 I-136 
                   1 HNMR(CD 3 OD) δ 1.26(s, 3H), 1.29(s, 3H), 3.38(s, 3H), 3.68(s, 3H), 3.80(dd, J=8.4, 2.7Hz, 1H), 3.96(dd, J=9.6, 8.4Hz, 1H), 4.34(dd, J=9.6, 
               
               
                   
                 2.7Hz, 1H), 6.44(s, 1H), 6.80(dd, J=8.1, 1.8Hz, 1H), 6.85(d, J=8.7Hz, 2H), 6.86(d, J=1.8Hz, 1H), 7.96(d, J=8.1Hz, 1H), 7.46(d, J=8.7Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(Nujol)3367, 1612, 1588, 1523, 1489, 1254, 1226, 1115, 1072, 1013, 940, 814cm −1   
               
               
                 I-137 
                   1 HNMR(CD 3 OD) δ 3.38(s, 3H), 3.68(s, 3H), 4.02(dd, J=11.0, 3.6Hz, 1H), 4.12(dd, J=11.0, 1.8Hz, 1H), 5.48(dd, J=3.6, 1.8Hz, 1H), 6.43 
               
               
                   
                 (s, 1H), 6.83–6.87(m, 3H), 6.85(d, J=8.7Hz, 2H), 7.46(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3410, 1612, 1588, 1522, 1487, 1269, 1231, 1114, 1071, 1011, 947, 824cm −1   
               
               
                 I-138 
                   1 HNMR(CD 3 OD) δ 3.38(s, 3H), 3.68(s, 3H), 4.70(d, J=5.4Hz, 2H), 6.43(s, 1H), 6.80(dd, J=8.1, 2.1Hz, 1H), 6.85(d, J=8.4Hz, 2H), 6.88( 
               
               
                   
                 d, J=2.1Hz, 1H), 6.98(d, J=8.1Hz, 1H), 7.46(d, J=8.4Hz, 2H), 7.62(t, J=5.4Hz, 1H) 
               
               
                   
                 IR(Nujol)3368, 1612, 1589, 1523, 1489, 1253, 1226, 1114, 1072, 1011, 940, 825cm −1   
               
               
                 I-139 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.74(s, 3H), 3.92(s, 3H), 4.75(d, J=5.1Hz, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.92(d, J=6.0Hz, 1H), 
               
               
                   
                 7.00(dd, J=6.0, 1.8Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.52(d, J=8.7Hz, 2H), 7.58(t, J=5.1Hz, 1H) 
               
               
                   
                 IR(Nujol)3399, 1612, 1589, 1523, 1489, 1252, 1226, 1115, 1072, 1043, 1014, 941, 825cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 35 
               
               
                   
               
             
            
               
                 I-140 
                   1 HNMR(CD 3 OD) δ 3.38(s, 3H), 3.68(s, 3H), 4.51(s, 2H), 4.71(d, J=5.4Hz, 2H), 6.43(s, 1H), 6.80(dd, J=8.4, 2.1Hz, 1H), 6.85(d, J=8.4Hz,  
               
               
                   
                 2H), 6.87(d, J=2.1Hz, 1H), 6.98(d, J=8.4Hz, 1H), 7.46(d, J=8.4Hz, 2H), 7.75(t, J=5.4Hz, 1H) 
               
               
                   
                 IR(Nujol)3384, 1611, 1588, 1523, 1489, 1252, 1227, 1115, 1072, 1014, 824, 758cm −1   
               
               
                 I-141 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.74(s, 3H), 4.76(d, J=5.1Hz, 2H), 5.15(s, 2H), 6.45(s, 1H), 6.86(d, J=8.4Hz, 1H), 6.92(d, J=8.7Hz, 2H),  
               
               
                   
                 6.94(dd, J=8.4, 2.1Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.31–7.40(m, 5H), 7.53(d, J=8.7Hz, 2H), 7.65(t, J=5.1Hz, 1H) 
               
               
                   
                 IR(Nujol)3399, 1611, 1588, 1523, 1489, 1251, 1225, 1115, 1072, 1013, 940, 825cm −1   
               
               
                 I-142 
                   1 HNMR(CDCl 3 ·CD 3 OD1:1) δ 3.26(s, 3H), 2.64(m, 4H), 3.13(m, 4H), 3.44(s, 3H), 3.73(s, 3H), 4.78(d, J=4.5Hz, 2H), 6.45(s, 1H), 6.90( 
               
               
                   
                 d, J=8.7Hz, 2H), 6.90(dd, J=8.4, 2.1Hz, 1H), 6.99(d, J=2.1Hz, 1H), 7.00(d, J=8.4Hz, 1H), 7.12(t, J=4.5Hz, 1H), 7.49(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3492, 3297, 1607, 1561, 1523, 1486, 1247, 1224, 1113, 1011, 957, 828, 799cm −1   
               
               
                 I-143 
                   1 HNMR(CDCl 3 ) δ 3.09(m, 4H), 3.45(s, 3H), 3.74(s, 3H), 3.86(m, 4H), 4.82(d, J=4.2Hz, 2H), 6.44(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.98(dd,  
               
               
                   
                 J=8.4, 1.8Hz, 1H), 7.00(t, J=4.2Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3366, 1611, 1586, 1523, 1488, 1268, 1227, 1114, 1070, 1011, 823cm −1   
               
               
                 I-144 
                   1 HNMR(CDCl 3 ) δ 1.29(t, J=6.9Hz, 3H), 2.65(dd, J=15.9, 6.6Hz, 1H), 2.81(dd, J=15.9, 6.6Hz, 1H), 3.44(s, 3H), 3.75(s, 3H), 4.03(dd, 
               
               
                   
                 J=11.4, 6.9Hz, 1H), 4.20(q, J=6.9Hz, 2H), 4.35(dd, J=11.4, 2.4Hz, 1H), 4.66(ddt, J=6.9, 6.6, 2.4Hz, 1H), 6.44(s, 1H), 6.92(d, J=8.7Hz, 2H), 
               
               
                   
                 6.96–7.01(m, 3H), 7.53(d, J=8.7Hz, 2H) 
               
               
                 I-145 
                 oil 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.55(m, 2H), 3.44(s, 3H), 3.75(s, 3H), 4.04(t, J=7.2Hz, 2H), 4.97(brs, 1H), 5.23( 
               
               
                   
                 m, 1H), 6.00(s, 1H), 6.45(s, 1H), 6.92&amp;7.53(ABq, J=8.7Hz, 4H), 7.02(m, 1H), 7.17–7.22(m, 2H) 
               
               
                   
                 IR(KBr)1613, 1525, 1490, 1475, 1463, 1454, 1402, 1304, 1269, 1231, 1112, 1072, 1019, 827cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 36 
               
               
                   
               
             
            
               
                 I-146 
                 m.p. 256–257° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.35(s, 3H), 3.44(s, 3H), 3.74(s, 3H), 5.22(s, 2H), 7.06(s, 1H), 7.28–7.56(m, 11H), 7.69(s, 1H), 7.76(d, J=8.6Hz, 2H) 
               
               
                   
                 IR(KBr): 3479, 3360, 1672, 1517, 1465, 1361, 1339, 1295, 1261, 1228, 1172, 1144, 1118, 1013, 957, 870, 852, 804, 751cm −1   
               
               
                 I-147 
                 m.p.. 163–164° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.74(s, 3H), 1.81(s, 3H), 3.43(s, 3H), 3.74(s, 3H), 4.58(d, J=6.8Hz, 2H), 5.50(t, J=6.8Hz, 1H), 5.80(s, 1H), 6.37(s, 1H),  
               
               
                   
                 6.86–6.95(m, 5H), 6.90(d, J=8.6Hz, 2H), 6.99(s, 1H), 7.49(d, J=8.6Hz, 2H) 
               
               
                   
                 IR(KBr): 3533, 3412, 3350, 1655, 1609, 1588, 1519, 1469, 1373, 1274, 1245, 1227, 1131, 1082, 1060, 999, 954, 838cm −1   
               
               
                 I-148 
                   1 HNMR(CDCl 3 ) δ 2.88(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 5.35(m, 2H), 6.85(s, 1H), 7.24(d, J=9.0Hz, 1H), 7.39(d, J=8.7Hz, 2H), 
               
               
                   
                 7.42–7.46(m, 5H), 7.65(d.d, J=9.0&amp;2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 8.26(d, J=2.1Hz, 1H) 
               
               
                 I-149 
                   1 HNMR(CDCl 3 ) δ 1.80(s, 3H), 1.85(s, 3H), 3.43(s, 3H), 3.74(s, 3H), 4.80(d, J=6.9Hz, 2H), 5.76(t, J=6.9Hz, 1H), 6.46(s, 1H), 6.92(d, 
               
               
                   
                 J=8.4Hz, 2H), 7.14(d, J=8.7Hz, 1H), 7.49(d, J=8.4Hz, 2H)7.70(d.d, J=8.7&amp;2.1Hz, 1H), 8.28(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr)3472, 1707, 1671, 1610, 1520, 1482, 1460, 1426, 1269, 1226, 1119, 1076, 1012cm −1   
               
               
                 I-150 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.63(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.62(d, J=6.3Hz, 2H), 4.73(s, 2H), 5.50(t, 
               
               
                   
                 J=6.3Hz, 1H), 6.84(s, 1H), 6.99(d, J=9.0Hz, 1H), 7.51–7.42(m, 9H), 7.70(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3432, 1607, 1512, 1479, 1364, 1234, 1176, 1151, 1079, 1016cm −1   
               
               
                 I-151 
                   1 HNMR(CDCl 3 ) δ 1.58(s, 3H), 1.81(s, 3H), 3.45(s, 3H), 3.73(s, 3H), 4.61(d, J=6.6Hz, 2H), 4.72(s, 2H), 5.52(t, J=6.6Hz, 1H), 6.45(s, 1H), 
               
               
                   
                 6.91(d, J=8.7Hz, 2H), 6.98(d, J=8.4Hz, 1H), 7.36(d.d, J=8.4&amp;2.1Hz, 1H), 7.38(d, J=2.1Hz, 1H), 7.50(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3580, 3411, 1611, 1521, 1485, 1464, 1397, 1233, 1113, 1077, 1024, 1001cm −1   
               
               
                 I-152 
                   1 HNMR(CDCl 3 ) δ 3.50(s, 3H), 3.77(s, 3H), 5.15(s, 2H), 5.72(s, 1H), 6.03(s, 2H), 6.71(d.d, J=8.4&amp;2.1Hz, 1H), 6.91(d, J=8.4Hz, 1H), 6.97 
               
               
                   
                 (s, 1H), 6.98(d, J=8.4Hz, 1H), 7.07(s, 1H), 7.09(d.d, J=8.4&amp;2.1Hz, 1H), 7.16(d, J=2.1Hz, 1H), 7.34–7.50(m, 5H), 989(s, 1H) 
               
               
                   
                 IR(KBr)3446, 1697, 1587, 1511, 1470, 1383, 1285, 1240, 1127, 1036cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 37 
               
               
                   
               
             
            
               
                 I-153 
                   1 HNMR(CDCl 3 ) δ 3.78(s, 3H), 3.79(s, 3H), 4.87(s, 1H), 5.16(s, 2H), 5.70(s, 1H), 6.88–6.91(m, 2H), 6.97(s, 1H), 7.00(s, 1H), 6.99(d, J=8.4Hz, 
               
               
                   
                 1H), 7.08(dd, J=2.1, 8.4Hz, 1H), 7.23(d, J=2.1Hz, 1H), 7.34–7.49(m, 7H) 
               
               
                 I-154 
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.74(s, 3H), 2.51–2.58(m, 2H), 3.19(s, 3H), 3.21(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 4.07(t, J=6.9Hz, 2H), 
               
               
                   
                 5.18–5.27(m, 1H), 6.92(s, 1H), 6.95(s, 1H), 7.05(d, J=8.7Hz, 1H), 7.32–7.37(m, 2H), 7.49(dd, J=2.1, 8.7Hz, 1H), 7.58(d, J=2.1Hz, 1H), 
               
               
                   
                 7.60–7.64(m, 2H) 
               
               
                 I-155 
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.75(s, 3H), 2.53(q, J=6.9Hz, 2H), 3.77(s, 3H), 3.78(s, 3H), 4.07(t, J=6.9Hz, 2H), 4.97(s, 3H), 5.20–5.25 
               
               
                   
                 (m, 1H), 5.71(s, 1H), 6.87–6.93(m, 3H), 7.07(dd, J=1.8, 8.4Hz, 1H), 7.20(d, J=1.8Hz, 1H), 7.45–7.50(m, 2H) 
               
               
                 I-156 
                 m.p. 163–175° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.76(s, 3H), 3.19(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 5.20(s, 2H), 5.68(s, 1H), 6.84(s, 1H), 6.97(d, J=1.8Hz,  
               
               
                   
                 1H), 6.99(d, J=1.8Hz, 1H), 7.37–7.47(m, 7H), 7.68(m, 2H) 
               
               
                   
                 IR(KBr)3436, 1480, 1415, 1391, 1363, 1233, 1178, 1151, 1079, 1024, 969, 953, 875, 801, 522cm −1   
               
               
                 I-157 
                 m.p. 176–178° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.08(s, 3H), 2.40, (s, 3H), 2.72(s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 5.13(s, 2H), 6.86(s, 1H), 7.39a 
               
               
                   
                 nd 7.68(ABq, J=8.7Hz, 4H), 7.47(d, J=2.1Hz, 1H), 7.49(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr)1770, 1747, 1477, 1391, 1366, 1235, 1180, 1152, 1077, 873, 799, 522cm −1   
               
               
                 I-158 
                 m.p. 175–177° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.87(s, 3H), 3.13(s, 6H), 3.22(s, 3H), 3.55(s, 3H), 3.81(s, 3H), 5.22(s, 2H), 6.86(s, 1H), 7.38–7.45(m, 7H), 7.51–7.53( 
               
               
                   
                 m, 2H), 7.67(m, 2H) 
               
               
                   
                 IR(KBr)1479, 1367, 1180, 1151, 1080, 1019, 966, 876, 798, 525cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 38 
               
               
                   
               
             
            
               
                 I-159 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.44(s, 3H), 3.21(s, 3H), 3.54(s, 3H), 3.76(s, 3H), 3.79(s, 3H), 4.77(s, 2H), 5.24(s, 2H), 6.83(s, 1H), 6.90–7.00(m, 3H),  
               
               
                   
                 7.30–7.48(m, 5H), 7.37(d, J=8.8Hz, 2H), 7.69(d, J=8.8Hz, 2H) 
               
               
                   
                 IR(KBr): 1758, 1519, 1481, 1365, 1236, 1176, 1150, 1079, 1013, 963, 872, 798cm −1   
               
               
                 I-160 
                 m.p.. 146–147° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.31(s, 3H), 3.65(s, 3H), 4.63(s, 2H), 5.15(s, 2H), 6.40(s, 1H), 6.83–6.90(m, 4H), 7.05(d, J=8.4Hz, 1H), 7.32–7.52 
               
               
                   
                 (m, 7H), 8.57(s, 1H), 9.50(s, 1H), 12.0–13.9(brs, 1H) 
               
               
                   
                 IR(KBr): 3422, 1728, 1611, 1524, 1489, 1455, 1405, 1247, 1142, 1118, 1080, 1012, 818, 749, 742, 698cm −1   
               
               
                 I-161 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.79(s, 3H), 2.57(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 3.80(s, 3H), 4.64(d, J=6.5Hz, 2H), 4.74(s,  
               
               
                   
                 2H), 5.54(t, J=6.5Hz, 1H), 6.83(s, 1H), 6.88(d, J=1.5Hz, 1H), 7.02–7.03(m, 2H), 7.38(d, J=8.7Hz, 2H), 7.69(d, J=8.7Hz, 2H) 
               
               
                 I-162 
                 m.p. 147–149° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.73(s, 3H), 1.77(s, 3H), 3.30(s, 3H), 3.65(s, 3H), 4.57(d, J=6.6Hz, 2H), 4.60(s, 2H), 5.86(t, J=6.6Hz, 1H), 6.40(s,  
               
               
                   
                 1H), 6.80(d, J=1.7Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.87(dd, J=8.7Hz, 1H), 6.99(d, J=8.7Hz, 1H), 7.43(d, J=8.7Hz, 2H), 8.56(s, 1H), 9.51( 
               
               
                   
                 s, 1H), 12.8(brs, 1H) 
               
               
                   
                 IR(KBr): 3483, 3376, 1737, 1612, 1523, 1489, 1460, 1397, 1271, 1231, 1175, 1120, 1072, 1012, 904, 820cm −1   
               
               
                 I-163 
                 m.p. 144–145° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.04(s, 3H), 3.20(s, 3H), 3.59(s, 3H), 3.75(s, 3H), 4.90(s, 2H), 5.16(s, 2H), 5.65(s, 1H), 6.67(s, 1H), 6.92(dd, J=2.1, 8.4Hz, 
               
               
                   
                 1H), 7.00(d, J=8.4Hz, 1H), 7.06(d, J=2.1Hz, 1H), 7.26–7.47(m, 7H), 7.61–7.66(m, 2H) 
               
               
                   
                 IR(KBr)3600–3200(br), 1517, 1477, 1449, 1382, 1361, 1277, 1235, 1199, 1150, 1112, 1079, 1064, 1010, 997cm −1   
               
               
                 I-164 
                 m.p. 80–83° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.99(s, 3H), 3.12(s, 3H), 3.20(s, 3H), 3.58(s, 3H), 3.75(s, 3H), 4.93(s, 3H), 5.18(s, 2H), 6.67(s, 1H), 7.12(d, J=8.7Hz,  
               
               
                   
                 1H), 7.34–7.49(m, 9H), 7.60–7.65(m, 2H) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 39 
               
               
                   
               
             
            
               
                 I-165 
                 m.p. 148–151° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.03(s, 3H), 3.57(s, 3H), 3.74(s, 3H), 4.89(s, 1H), 4.90(s, 2H), 5.15(s, 2H), 5.64(s, 1H), 6.67(s, 1H), 6.88–6.93(m, 3H),  
               
               
                   
                 6.99(d, J=8.4Hz, 1H), 7.06(d, J=1.8Hz, 1H), 7.20–7.49(m, 7H) 
               
               
                   
                 IR(KBr)3600–3200(br), 1609, 1590, 1519, 1477, 1459, 1381, 1253, 1216, 1156, 1111, 1077, 1066, 1012cm −1   
               
               
                 I-166 
                 m.p. 199° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.10(s, 3H), 3.21(s, 3H), 3.44(s, 3H), 3.76(s, 3H), 5.17(s, 2H), 6.03(s, 1H), 6.44(s, 1H), 7.14(d, J=8.4Hz, 1H), 7.36–7.49 
               
               
                   
                 (m, 8H), 7.52(d, J=2.1Hz, 1H), 7.67–7.72(m, 2H) 
               
               
                   
                 IR(KBr)3600–3200(br), 1520, 1486, 1362, 1183, 1152, 1110, 971cm −1   
               
               
                 I-167 
                 m.p. 113–115° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 0.76(t, J=7.2Hz, 3H), 1.46–1.55(m, 2H), 3.11(s, 3H), 3.20(s, 1H), 3.63(s, 1H), 3.71(t, J=6.6Hz, 2H), 5.18(s, 2H), 6.64 
               
               
                   
                 (s, 1H), 7.11(d, J=8.7Hz, 1H), 7.33–7.50(m, 9H), 7.60–7.65(m, 2H) 
               
               
                   
                 IR(KBr)1517, 1475, 1365, 1345, 1293, 1233, 1177, 1149, 1109, 1079, 1017, 956cm −1   
               
               
                 I-168 
                 m.p. 56–58° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 0.76(t, J=7.5Hz, 3H), 1.44–1.56(m, 2H), 3.61(s, 3H), 3.71(t, J=6.6Hz, 2H), 3.74(s, 3H), 4.86(s, 1H), 5.15(s, 2H), 5.63 
               
               
                   
                 (s, 1H), 6.65(s, 1H), 6.88–6.93(m, 3H), 6.98(d, J=8.4Hz, 1H), 7.04(d, J=1.8Hz, 1H), 7.37–7.50(m, 7H) 
               
               
                   
                 IR(KBr)3600–3200(br), 1611, 1590, 1519, 1476, 1404, 1379, 1252, 1230, 1110, 1078, 1015cm −1   
               
               
                 I-169 
                 m.p. 101–103° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 0.77(t, J=7.5Hz, 3H), 1.44–1.55(m, 2H), 1.76(s, 3H), 1.81(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.63(s, 3H), 3.71(t, J=6.6Hz,  
               
               
                   
                 2H), 3.75(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.48–5.53(m, 1H), 6.64(s, 1H), 7.04(d, J=8.4Hz, 1H), 7.32–7.38(m, 3H), 7.42(d, J=2.1Hz, 1H),  
               
               
                   
                 7.60–7.65(m, 2H) 
               
               
                   
                 IR(KBr)1514, 1473, 1370, 1359, 1290, 1233, 1174, 1149, 1107, 970cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 40 
               
               
                   
               
             
            
               
                 I-170 
                 m.p. 64–66° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 0.77(t, J=7.5Hz, 3H), 1.44–1.55(m, 2H), 1.76(s, 3H), 1.81(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.63(s, 3H), 3.71(t, J=6.6Hz, 2H), 
               
               
                   
                 3.75(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.48–5.53(m, 1H), 6.64(s, 1H), 7.04(d, J=8.4Hz, 1H), 7.32–7.38(m, 3H), 7.42(d, J=2.1Hz, 1H), 
               
               
                   
                 7.60–7.65(m, 2H)IR(KBr)3600–2800(br), 1612, 1590, 1520, 1475, 1462, 1405, 1381, 1285, 1244, 1226, 1110, 1079, 988cm −1   
               
               
                 I-171 
                 m.p. 148–150° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.74(d, J=0.9Hz, 3H), 1.80(s, 3H), 2.88(s, 3H), 3.22(s, 3H), 3.23(s, 6H), 3.55(s, 3H), 3.80(s, 3H), 4.72(d, J=7.5Hz, 2H), 
               
               
                   
                 5.55(m, 1H), 6.85(s, 1H), 7.39&amp;7.67(ABq, J=8.7Hz, 4H), 7.40(s, 2H) 
               
               
                   
                 IR(KBr)1514, 1479, 1411, 1366, 1179, 1152, 1079, 1022, 968, 875, 799, 525cm −1   
               
               
                 I-172 
                   1 HNMR(CDCl 3 ) δ 0.94(t, J=7.2Hz, 3H), 1.45(tq, J=7.2, 7.2Hz, 2H), 2.13(m, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.68(d, J=5.4Hz, 2H), 5.72 
               
               
                   
                 (m, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(brs, 2H), 7.07(brs, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                 I-173 
                   1 HNMR(CDCl 3 ) δ 1.76(brd, J=6.3Hz, 3H), 3.46(s, 3H), 3.74(s, 3H), 4.70(d, J=5.4Hz, 2H), 5.77(m, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 
               
               
                   
                 6.96(brs, 2H), 7.07(brs, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3350, 1613, 1587, 1523, 1491, 1287, 1261, 1238, 1114, 1071, 1011, 936, 820, 783cm −1   
               
               
                 I-174 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.76(s, 3H), 4.56(s, 2H), 5.55(s, 1H), 6.45(s, 1H), 6.93(d, J=8.7Hz, 2H), 7.01(d, J=8.4Hz, 1H), 7.08(dd, J=8.4, 
               
               
                   
                 2.1Hz, 1H), 7.27(d, J=2.1Hz, 1H), 7.54(d, J=8.7Hz, 2H) 
               
               
                 I-175 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.74(s, 3H), 4.82(dd, J=6.6, 1.5Hz, 2H), 5.28(d, J=10.5Hz, 1H), 5.35(d, J=16.5Hz, 1H), 5.75(dt, J=10.8, 
               
               
                   
                 6.6Hz, 1H), 6.26(dd, J=10.5, 10.5Hz, 1H), 6.45(s, 1H), 6.66(ddd, J=16.5, 10.5, 10.5Hz, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(m, 2H), 7.07(brs, 
               
               
                   
                 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3399, 1611, 1591, 1523, 1489, 1248, 1226, 1113, 1071, 1009, 825cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 41 
               
               
                   
               
             
            
               
                 I-176 
                   1 HNMR(CDCl 3 ) δ 1.59(m, 6H), 2.17(m, 2H), 2.24, (m, 2H), 2.71(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.65(d, J=7.2Hz, 
               
               
                   
                 2H), 5.43(t, J=7.2Hz, 1H), 6.84(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.34(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.39(d, J=2.1Hz, 1H), 7.68(d, 
               
               
                   
                 J=8.7Hz, 2H) 
               
               
                 I-177 
                 m.p. 177–178° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.31(t, J=5.7Hz, 2H), 2.39(t, J=5.7Hz, 2H), 2.76(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.70(t, J=5.7Hz, 2H), 3.73(t, 
               
               
                   
                 J=5.7Hz, 2H), 3.78(s, 3H), 4.67(d, J=6.6Hz, 2H), 5.57(t, J=6.6Hz, 1H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.35(dd, J=8.4, 2.1Hz, 1H), 7.38(d, 
               
               
                   
                 J=8.7Hz, 2H), 7.39(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)2940, 1519, 1481, 1362, 1178, 1152, 1079, 818cm −1   
               
               
                 I-178 
                   1 HNMR(CDCl 3 ) δ 1.04(t, J=7.5Hz, 3H), 1.05(t, J=7.5Hz, 3H), 2.12(q, J=7.5Hz, 2H), 2.16(q, J=7.5Hz, 2H), 2.71(s, 3H), 3.21(s, 3H), 3.24 
               
               
                   
                 (s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.67(d, J=6.6Hz, 2H), 5.45(t, J=6.6Hz, 1H), 6.84(s, 1H), 7.11(d, J=8.4Hz, 1H), 7.35(dd, J=8.4, 2.4Hz, 
               
               
                   
                 1H), 7.38(d, J=8.7Hz, 2H), 7.39(d, J=2.4Hz, 1H), 7.68(d, J=8.7Hz, 2H) 
               
               
                 I-179 
                   1 HNMR(CDCl 3 ) δ 1.05(t, J=7.5Hz, 3H), 1.76(s, 3H), 2.10(q, J=7.5Hz, 2H), 2.71(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 
               
               
                   
                 4.66(d, J=6.9Hz, 2H), 5.48(t, J=6.9Hz, 1H), 6.84(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.34(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.39 
               
               
                   
                 (d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) 
               
               
                 I-180 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(s, 6H), 2.72(s, 3H), 3.21(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.61(s, 2H), 6.84(s, 1H), 7.10 
               
               
                   
                 (d, J=8.4Hz, 1H), 7.34(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.39(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) 
               
               
                 I-181 
                 m.p. 157–158° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.55–1.65(m, 6H), 2.18(m, 2H), 2.23(m, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.63d, J=7.2Hz, 2H), 5.47(t, J=7.2Hz, 1H), 6.45 
               
               
                   
                 (s, 1H), 6.91(d, J=8.4Hz, 2H), 6.96(br.s, 2H), 7.06(br.s, 1H), 7.52(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3410, 2924, 2854, 1609, 1567, 1523, 1490, 1462, 1405, 1254, 1221, 1198, 1119, 1069, 824, 813cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 42 
               
               
                   
               
             
            
               
                 I-182 
                 m.p. 219–221° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.22(t, J=5.4Hz, 2H), 2.32(t, J=5.4Hz, 2H), 3.30(s, 3H), 3.56(t, J=5.4Hz, 2H), 3.61(t, J=5.4Hz, 2H), 3.64(s, 3H), 
               
               
                   
                 4.59(d, J=6.6Hz, 2H), 5.54(t, J=6.6Hz, 1H), 6.39(s, 1H), 6.64(dd, J=8.4, 2.1Hz, 1H), 6.73(d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.89(d, 
               
               
                   
                 J=8.4Hz, 1H), 7.43(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3392, 2948, 1609, 1586, 1522, 1492, 1271, 1239, 1219, 1118, 1076, 1007, 818cm −1   
               
               
                 I-183 
                 m.p. 149–150° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.03(t, J=7.5Hz, 3H), 1.07(t, J=7.5Hz, 3H), 2.13(q, J=7.5Hz, 2H), 2.15(q, J=7.5Hz, 2H), 3.46(s, 3H), 3.75(s, 3H), 4.64(d, 
               
               
                   
                 J=6.6Hz, 2H), 5.48(t, J=6.6Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.97(dd, J=7.8, 1.5Hz, 1H), 6.97(d, J=7.8Hz, 1H), 7.06(d, 
               
               
                   
                 J=1.5Hz, 1H), 7.52(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3398, 2963, 2934, 1671, 1610, 1523, 1493, 1465, 1407, 1259, 1224, 1118, 1071, 813cm −1   
               
               
                 I-184 
                 m.p. 217–218° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.86(s, 3H), 5.16(s, 2H), 5.72(s, 1H), 6.97–7.01(m, 3H), 7.12(dd, J=2.4, 8.4Hz, 1H), 7.26(d, J=2.4Hz, 1H), 7.34–7.47 
               
               
                   
                 (m, 5H), 7.54–7.58(m, 2H), 7.60(s, 4H) 
               
               
                   
                 IR(KBr)3600–3200(br), 1605, 1590, 1493, 1298, 1282, 1253, 1206, 1183, 1022cm −1   
               
               
                 I-185 
                   1 HNMR(CDCl 3 ) δ 1.21(t, J=6.9Hz, 3H), 1.77(s, 3H), 1.82(s, 3H), 2.38–2.46(m, 2H), 2.72–2.84(m, 2H), 3.18(s, 3H), 3.21(s, 3H), 3.35(s, 
               
               
                   
                 3H), 3.70(s, 3H), 4.06(q, J=6.9Hz, 2H), 4.63(d, J=6.6Hz, 2H), 5.52(t, J=6.6Hz, 1H), 6.75(s, 1H), 7.07(d, J=8.4Hz, 1H), 7.13(d.d, J=8.4&amp; 
               
               
                   
                 2.1Hz, 1H), 7.21(d, J=2.1Hz, 1H), 7.37(d, J=9.0Hz, 2H), 7.69(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)1727, 1517, 1469, 1364, 1291, 1234, 1179, 1152, 1118, 1080, 1003cm −1   
               
               
                 I-186 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 2.42–2.53(m, 2H), 2.72–2.86(m, 2H), 3.35(s, 3H), 3.69(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.53(t, 
               
               
                   
                 J=6.6Hz, 1H), 5.71(s, 1H), 6.68(d.d, J=8.4&amp;2.1Hz, 1H), 6.76(s, 1H), 6.81(d, J=2.1Hz, 1H), 6.91(d, J=8.4Hz, 2H), 6.92(d, J=8.4Hz, 1H), 
               
               
                   
                 7.52(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3419, 1707, 1612, 1518, 1472, 1390, 1225, 1078cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 43 
               
               
                   
               
             
            
               
                 I-187 
                   1 HNMR(CDCl 3 ) δ 2.55(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 5.18(s, 1H), 6.85(s, 1H), 6.91(d.d, J=8.4&amp;2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.04 
               
               
                   
                 (d, J=2.1Hz, 1H), 7.33–7.48(m, 5H), 7.71(d, J=8.4Hz, 2H), 7.72(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3442, 1617, 1517, 1485, 1485, 1394, 1357, 1331, 1171, 1124, 1077, 1067, 1016cm −1   
               
               
                 I-188 
                   1 HNMR(CDCl 3 ) δ 2.68(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.31–7.50(m, 7H), 7.72 
               
               
                   
                 (d, J=8.7Hz, 2H), 7.76(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)1614, 1513, 1482, 1366, 1324, 1177, 1120, 1079, 1065, 1016cm −1   
               
               
                 I-189 
                   1 HNMR(CDCl 3 ) δ 2.68(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.31–7.50(m, 7H), 7.72 
               
               
                   
                 (d, J=8.7Hz, 2H), 7.76(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)1614, 1513, 1482, 1366, 1324, 1177, 1120, 1079, 1065, 1016cm −1   
               
               
                 I-190 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.76(s, 3H), 4.62(d, J=8.4Hz, 2H), 5.53(t, J=8.4Hz, 1H), 5.71(s, 1H), 5.85(s, 1H), 
               
               
                   
                 6.46(s, 1H), 6.94(d.d, J=8.1&amp;1.8Hz, 1H), 6.98(d, J=8.1Hz, 1H), 7.05(d, J=1.8Hz, 1H), 7.71(d, J=8.1Hz, 2H), 7.77(d, J=8.1Hz, 2H) 
               
               
                   
                 IR(KBr)3552, 3505, 3466, 1613, 1509, 1487, 1397, 1324, 1288, 1245, 1163, 1110, 1065cm −1   
               
               
                 I-191 
                   1 HNMR(CDCl 3 ) δ 3.02(s, 6H), 3.48(s, 3H), 3.76(s, 3H), 5.15(s, 2H), 5.67(s, 1H), 5.95(s, 1H), 6.47(s, 1H), 6.81(d, J=8.7Hz, 2H), 
               
               
                   
                 6.96(d.d, J=8.4&amp;2.1Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.10(d, J=2.1Hz, 1H), 7.31–7.49(m, 5H), 7.55(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3543, 3500, 1605, 1526, 1486, 1459, 1245, 1198, 1110, 1070, 999cm −1   
               
               
                 I-192 
                 mp 122–124° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.70(brs, 3H), 3.55–3.60(br, 2H), 3.60(s, 3H), 3.75(s, 3H), 3.81–3.83(m, 2H), 3.87(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 6.69 
               
               
                   
                 (s, 1H), 6.94(dd, J=2.1, 8.4Hz, 1H), 6.97–7.03(m, 3H), 7.07(d, J=1.8Hz, 1H), 7.38–7.48(m, 5H), 7.51–7.56(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1607, 1597, 1550, 1518, 1477, 1462, 1452, 1392, 1289, 1248, 1228, 1175, 1122, 1096, 1084, 1015cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 44 
               
               
                   
               
             
            
               
                 I-193 
                 m.p. 160–163° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.60(s, 3H), 3.60–3.64(br, 2H), 3.76(s, 3H), 3.77–3.80(m, 2H), 5.15(s, 2H), 5.69(s, 1H), 5.88(s, 1H), 6.69(s, 1H), 6.90–6.94 
               
               
                   
                 (m, 3H), 7.02(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.38–7.51(m, 7H) 
               
               
                   
                 IR(KBr)3600–3200(br), 1613, 1588, 1519, 1477, 1462, 1397, 1256, 1189, 1117, 1078, 1011cm −1   
               
               
                 I-194 
                   1 HNMR(CDCl 3 ) δ 3.02(s, 6H), 3.11(s, 3H), 3.50(s, 3H), 3.72(s, 3H), 4.43(brs, 1H), 4.58(brs, 1H), 5.18(s, 2H), 6.82(d, J=8.7Hz, 2H), 6.92 
               
               
                   
                 (s, 1H), 7.16(d, J=9.3Hz, 1H), 7.31–7.51(m, 7H), 7.55(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3432, 1611, 1526, 1476, 1356, 1291, 1232, 1186, 1117, 1079, 1012cm −1   
               
               
                 I-195 
                 m.p. 157–158° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.10(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.69(s, 3H), 3.76(s, 3H), 4.47(s, 2H), 5.17(s, 2H), 6.68(s, 1H), 7.12(d, J=8.2Hz, 
               
               
                   
                 1H), 7.34–7.50(m, 9H), 7.63(d, J=8.6Hz, 2H) 
               
               
                   
                 IR(KBr): 1748, 1517, 1476, 1366, 1232, 1150, 1114, 968, 873, 812, 791, 750, 707cm −1   
               
               
                 I-196 
                 m.p. 189–191° C. (dec) 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.45(s, 3H), 3.67(s, 3H), 4.25(s, 2H), 5.12(s, 2H), 6.66(dd, J=8.4, 2.0Hz, 1H), 6.69(s, 1H), 6.77(d, J=2.0Hz, 1H), 6.80 
               
               
                   
                 (d, J=8.6Hz, 2H), 6.98(d, J=8.4Hz, 1H), 7.33–7.54(m, 7H), 9.01(s, 1H), 9.54(brs, 1H) 
               
               
                   
                 IR(KBr): 3422, 3245, 1733, 1611, 1596, 1522, 1478, 1400, 1262, 1248, 1222, 1207, 1130, 1084, 1011, 836, 781, 744, 699cm −1   
               
               
                 I-197 
                 m.p. 151–152° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.70(s, 3H), 3.75(s, 3H), 4.47(s, 2H), 4.63(d, J=6.9Hz, 
               
               
                   
                 2H), 5.51(t, J=6.9Hz, 1H), 6.68(s, 1H), 7.05(d, J=8.4Hz, 1H), 7.36(dd, J=8.4, 2.1Hz, 1H), 7.36(d, J=8.9Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.63 
               
               
                   
                 (d, J=8.9Hz, 2H) 
               
               
                   
                 IR(KBr): 1751, 1517, 1475, 1366, 1234, 1150, 1113, 968, 872, 812, 707cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 45 
               
               
                   
               
             
            
               
                 I-198 
                 m.p. 155–156° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.76(s, 3H), 3.42(s, 3H), 3.67(s, 3H), 4.25(s, 2H), 4.54(d, J=6.8Hz, 2H), 5.49(t, J=6.8Hz, 1H), 6.65(dd, 
               
               
                   
                 J=8.4, 1.9Hz, 1H), 6.69(s, 1H), 6.73(d, J=1.9Hz, 1H), 6.84(d, J=8.4Hz, 2H), 7.36(d, J=8.4Hz, 1H), 7.41(d, J=8.4Hz, 2H), 8.85(s, 1H), 9.55(s, 
               
               
                   
                 1H), 11.2–13.6(brs, 1H) 
               
               
                   
                 IR(KBr): 3411, 3243, 1733, 1611, 1594, 1522, 1477, 1398, 1247, 1207, 1126, 1083, 1015, 835, 788cm −1   
               
               
                 I-199 
                   1 HNMR(CDCl 3 ) δ 2.68(s, 3H), 3.13(s, 3H), 3.55(s, 3H), 3.80(s, 3H), 5.19(s, 2H), 6.88(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.34(d, J=2.1Hz, 1H), 
               
               
                   
                 7.36–7.50(m, 6H), 7.81(d, J=8.4Hz, 2H), 7.98(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1698, 1602, 1481, 1351, 1232, 1182, 1079cm −1   
               
               
                 I-200 
                   1 HNMR(CDCl 3 ) δ 2.42(s, 3H), 2.71(s, 3H), 3.03(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.79(s, 3H), 5.17(s, 2H), 6.84(s, 1H), 7.19(d, J=8.4Hz, 
               
               
                   
                 1H), 7.22–7.30(m, 3H), 7.37(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.41–7.45(m, 1H), 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)1607, 1519, 1480, 1177, 1151, 1079, 970, 875, 798cm −1   
               
               
                 I-201 
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 2.67(s, 3H), 3.14(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.15(s, 2H), 6.84(s, 1H), 7.14(d, J=8.4Hz, 
               
               
                   
                 1H), 7.17(brd, J=7.5Hz, 1H), 7.23–7.30(m, 3H), 7.34(dd, J=8.4, 1.8Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=1.8Hz, 1H), 7.68(d, J=8.7Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(Nujol)1606, 1519, 1482, 1180, 1150, 1078, 1011, 979, 876, 790cm −1   
               
               
                 I-202 
                   1 HNMR(CDCl 3 ) δ 2.30(s, 3H), 2.38(s, 6H), 2.74(s, 3H), 2.94(s, 3H), 3.21(s, 3H), 3.57(s, 3H), 3.79(s, 3H), 5.13(s, 2H), 6.85(s, 1H), 6.91 
               
               
                   
                 (brs, 2H), 7.37(d, J=8.7Hz, 2H), 7.40(brs, 2H), 7.41(dd, J=8.4, 1.8Hz, 1H), 7.69(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(CHCl 3 )1610, 1518, 1477, 1370, 1177, 1149, 1082, 970, 873cm −1   
               
               
                 I-203 
                   1 HNMR(CDCl 3 ) δ 2.34(s, 6H), 2.66(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.12(s, 2H), 6.84(s, 1H), 6.99(brs, 1H), 7.06 
               
               
                   
                 (brs, 2H), 7.14(d, J=8.4Hz, 1H), 7.33(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)1607, 1519, 1480, 1178, 1152, 1097, 1014, 969, 876, 824, 797cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 46 
               
               
                   
               
             
            
               
                 I-204 
                   1 HNMR(CDCl 3 ) δ 2.72(s, 3H), 3.16(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 3.94(s, 3H), 5.25(s, 2H), 6.84(s, 1H), 7.11(d, J=8.4Hz, 
               
               
                   
                 1H), 7.34(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H), 7.55(d, J=8.4Hz, 2H), 7.68(d, J=8.7Hz, 2H), 8.09(d, J=8.4Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(Nujol)1719, 1610, 1519, 1480, 1177, 1151, 1119, 1080, 1016, 969, 875, 798cm −1   
               
               
                 I-205 
                 m.p. 153–157° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.70(s, 3H), 3.16(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.13(s, 2H), 6.41(dd, J=3.3, 2.0Hz, 1H), 6.49(d, J=3.3Hz, 
               
               
                   
                 1H), 6.84(s, 1H), 7.20(d, J=8.7Hz, 1H), 7.37(dd, J=8.7, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.46(d, J=2.0Hz, 1H), 
               
               
                   
                 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)1605, 1518, 1482, 1375, 1361, 1180, 1150, 1079, 1013, 977, 876, 814, 800cm −1   
               
               
                 I-206 
                   1 HNMR(CDCl 3 ) δ 2.41(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 5.13(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.99(dd, J=8.4, 2.1Hz, 1H), 7.07 
               
               
                   
                 (d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.22–7.34(m, 3H), 7.40(brd, J=7.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3471, 3436, 3339, 1612, 1581, 1523, 1489, 1266, 1245, 1228, 1185, 1110, 1070, 1011, 998, 945, 823, 781cm −1   
               
               
                 I-207 
                   1 HNMR(CDCl 3 ) δ 2.40(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.11(s, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.95(dd, J=8.4, 1.8Hz, 1H), 7.01 
               
               
                   
                 (d, J=8.4Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.19(brd, J=7.5Hz, 1H), 7.22–7.34(m, 3H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3410, 1611, 1589, 1523, 1489, 1246, 1225, 1114, 1071, 1011, 939, 824, 814, 778cm −1   
               
               
                 I-208 
                 m.p. 230–236° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.25(s, 3H), 2.35(s, 6H), 3.31(s, 3H), 3.65(s, 3H), 5.00(s, 2H), 6.39(s, 1H), 6.69(dd, J=8.4, 1.8Hz, 1H), 6.76(d, J=1.8Hz, 
               
               
                   
                 1H), 6.84(d, J=8.7Hz, 1H), 6.90(brs, 2H), 7.06(d, J=8.4Hz, 3H), 7.44(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3475, 3361, 1609, 1579, 1521, 1260, 1244, 1110, 1071, 1012, 988, 822, 782cm −1   
               
               
                 I-209 
                   1 HNMR(CDCl 3 ) δ 2.35(s, 6H), 3.45(s, 3H), 3.75(s, 3H), 5.07(s, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.95(dd, J=8.4, 1.8Hz, 1H), 7.01 
               
               
                   
                 (brs, 1H), 7.02(d, J=8.4Hz, 1H), 7.06(brs, 2H), 7.08(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3410, 1610, 1588, 1523, 1489, 1248, 1225, 1114, 1071, 1011, 940, 825, 808,cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 47 
               
               
                   
               
             
            
               
                 I-210 
                   1 HNMR(CD 3 OD) δ 3.37(s, 3H), 3.67(s, 3H), 5.25(s, 2H), 6.43(s, 1H), 6.77(dd, J=8.4, 2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.89(d, J=2.1Hz, 
               
               
                   
                 1H), 6.94(d, J=8.4Hz, 1H), 7.45(d, J=8.7Hz, 2H), 7.60(d, J=8.4Hz, 2H), 8.04(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(Nujol)3384, 1694, 1612, 1591, 1523, 1488, 1249, 1113, 1071, 1013, 940, 826, 812, 765cm −1   
               
               
                 I-211 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.74(s, 3H), 5.09(s, 3H), 6.41(dd, J=3.3, 1.8Hz, 1H), 6.45(s, 1H), 6.47(d, J=3.3Hz, 1H), 6.92(d, J=8.7Hz, 
               
               
                   
                 2H), 6.97(dd, J=8.4, 2.1Hz, 1H), 7.07(d, J=2.1Hz, 1H), 7.08(d, J=8.4Hz, 1H), 7.48(dd, J=1.8, 1.0Hz, 1H), 7.54(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3410, 1612, 1589, 1523, 1489, 1248, 1226, 1113, 1071, 1011, 939, 815, 747cm −1   
               
               
                 I-212 
                 m.p. 156–158° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.06(t, J=7.4Hz, 3H), 1.75(s, 3H), 2.10(q, J=7.4Hz, 2H), 3.46(s, 3H), 3.75(s, 3H), 4.64(d, J=7.0Hz, 2H), 5.52(t, J=7.0Hz, 
               
               
                   
                 1H), 6.45(s, 1H), 6.92(d, J=8.6Hz, 2H), 6.96(br.s, 2H), 7.06(br.s, 1H), 7.53(d, J=8.6Hz, 2H) 
               
               
                   
                 IR(KBr)3392, 2960, 2934, 1610, 1583, 1568, 1523, 1492, 1465, 1406, 1259, 1241, 1224, 1198, 1118, 1071, 824, 812cm −1   
               
               
                 I-213 
                 m.p. 175–177° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.80(s, 6H), 3.46(s, 3H), 3.75(s, 3H), 4.59(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(br.s, 2H), 7.06 
               
               
                   
                 (br.s, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3449, 2929, 1612, 1581, 1523, 1489, 1403, 1262, 1243, 1228, 1113, 1070, 823, 807cm −1   
               
               
                 I-214 
                   1 HNMR(CDCl 3 ) δ 1.66(tt, J=6.6, 6.6Hz, 2H), 1.74(tt, J=6.6, 6.6Hz, 2H), 2.32(t, J=6.6Hz, 2H), 2.34(t, J=6.6Hz, 2H), 2.71(s, 3H), 3.21 
               
               
                   
                 (s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.60(m, 1H), 6.84(s, 1H), 7.09(d, J=8.7Hz, 1H), 7.34(dd, J=8.7, 2.1Hz, 
               
               
                   
                 1H), 7.37(d, J=8.7Hz, 2H), 7.38(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)2941, 1610, 1518, 1418, 1365, 1177, 1151, 1079, 847, 818cm −1   
               
               
                 I-215 
                   1 HNMR(CDCl 3 ) δ 1.57–1.72(m, 4H), 2.05–2.13(m, 4H), 2.70(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.48(s, 2H), 5.86 
               
               
                   
                 (s, 1H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.34(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.38(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)2936, 1610, 1518, 1481, 1365, 1177, 1151, 1079, 818cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 48 
               
               
                   
               
             
            
               
                 I-216 
                   1 HNMR(CDCl 3 ) δ 1.74(d, J=6.6Hz, 3H), 2.54(d, J=2.1Hz, 1H), 2.70(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.00(dd, J=6.6, 
               
               
                   
                 2.1Hz, 1H), 6.84(s, 1H), 7.28(d, J=8.7Hz, 1H), 7.36(dd, J=8.7, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr)3282, 3023, 2940, 1609, 1519, 1481, 1365, 1177, 1151, 1079, 970, 815cm −1   
               
               
                 I-217 
                 m.p. 80–85° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.62–1.77(m, 4H), 2.25–2.39(m, 4H), 3.46(s, 3H), 3.75(s, 3H), 4.60(d, J=7.0Hz, 2H), 5.63(m, 1H), 6.45(s, 1H), 6.92 
               
               
                   
                 (d, J=8.6Hz, 1H), 6.95(br.s, 2H), 7.06(br.s, 1H), 7.68(d, J=8.6Hz, 2H) 
               
               
                   
                 IR(KBr)3282, 3023, 2940, 1609, 1519, 1481, 1365, 1177, 1151, 1079, 970, 815cm −1   
               
               
                 I-218 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 5.69(brs, 1H), 5.86(s, 1H), 6.47(s, 1H), 6.95(dd, J=2.1, 8.4Hz, 1H), 7.04(d, J=8.4Hz, 
               
               
                   
                 1H), 7.08(d, J=2.1Hz, 1H), 7.34–7.65(m, 7H), 7.83–7.92(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3530, 3022, 1614, 1588, 1500, 1485, 1463, 1405, 1326, 1290, 1249, 1168, 1130, 1117, 1073, 1011cm −1   
               
               
                 I-219 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.74(s, 3H), 2.51–2.59(m, 2H), 2.74(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 4.07(t, J=6.6Hz, 2H), 5.21 
               
               
                   
                 (m, 1H), 6.85(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.35(dd, J=2.1, 8.7Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.55–7.69(m, 2H), 7.81–7.87(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3024, 1609, 1519, 1481, 1467, 1396, 1369, 1321, 1272, 1179, 1122, 1082, 1015cm −1   
               
               
                 I-220 
                 m.p. 124–126° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.75(s, 3H), 2.50–2.57(m, 2H), 3.46(s, 3H), 3.76(s, 3H), 4.07(t, J=6.9Hz, 2H), 5.22(m, 1H), 5.69(brs, 1H), 
               
               
                   
                 5.84(s, 1H), 6.46(s, 1H), 6.93–7.05(m, 3H), 7.55–7.65(m, 2H), 7.82–7.91(m, 2H). 
               
               
                   
                 IR(KBr)3406, 2935, 1587, 1519, 1501, 1488, 1459, 1359, 1323, 1304, 1291, 1274, 1223, 1170, 1126, 1113, 1075, 1018cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 49 
               
               
                   
               
             
            
               
                 I-221 
                 m.p. 187–189° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.33(s, 3H), 2.69(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.17(s, 2H), 6.84(s, 1H), 7.12&amp;7.25(ABq, 
               
               
                   
                 J=8.7Hz, 4H), 7.31(dd, J=8.1Hz, J=1.5Hz, 1H), 7.38&amp;7.67(ABq, J=8.7Hz, 4H), 7.42(d, J=8.1Hz, 1H), 7.46(d, J=1.5Hz, 1H) 
               
               
                   
                 IR(KBr)1512, 1474, 1417, 1391, 1356, 1343, 1177, 1149, 1082, 1054, 1013, 976, 961, 939, 867, 854, 844, 820, 812, 799, 523cm −1   
               
               
                 I-222 
                 m.p. 107–112° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.73(s, 3H), 3.22(s, 3H), 3.28(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.34(s, 2H), 6.84(s, 1H), 7.19(m, 1H), 7.30(dd, J=8.1Hz, 
               
               
                   
                 J=1.8Hz, 1H), 7.34–7.41(m, 3H), 7.46(d, J=1.8Hz, 1H), 7.49(d, J=8.1Hz, 1H), 7.62–7.69(m, 3H), 8.55(m, 1H) 
               
               
                   
                 IR(KBr)1474, 1389, 1364, 1179, 1151, 1081, 937, 873, 813, 797, 523cm −1   
               
               
                 I-223 
                 m.p. 212–214° C. 
               
               
                   
                   1 HNMR(CDCl 3 +CD 3 OD) δ 3.45(s, 3H), 3.74(s, 3H), 4.13(s, 2H), 6.45(s, 1H), 6.90–6.96(m, 3H), 7.12(d, J=1.8Hz, 1H), 7.18–7.26(m, 2H), 
               
               
                   
                 7.48–7.54(m, 3H), 7.68(m, 1H), 8.63(m, 1H) 
               
               
                   
                 IR(KBr)3504, 3272, 1612, 1596, 1574, 1521, 1492, 1463, 1436, 1405, 1362, 1310, 1265, 1222, 1172, 1116, 1083, 1052, 1017, 828cm −1   
               
               
                 I-224 
                 m.p. 199–200° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.46(d, J=0.9Hz, 3H), 1.77(s, 3H), 3.44(s, 3H), 3.74(s, 3H), 3.90(m, 2H), 5.25(m, 1H), 6.04(brs, 1H), 6.45(s, 1H), 6.93 
               
               
                   
                 &amp;7.53(ABq, J=8.7Hz, 4H), 7.00(m, 2H), 7.05(m, 1H) 
               
               
                   
                 IR(KBr)3404, 2999, 2932, 1612, 1595, 1522, 1483, 1454, 1432, 1401, 1376, 1357, 1271, 1223, 11 19, 1080, 1055, 1015, 974, 938, 829, 817cm −1   
               
               
                 I-225 
                 m.p. 181–183° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.37(s, 9H), 3.45(s, 3H), 3.75(s, 3H), 4.93(brs, 1H), 6.00(s, 1H), 6.46(s, 1H), 6.93&amp;7.54(ABq, J=8.7Hz, 4H), 6.99(s, 
               
               
                   
                 1H), 7.01(dd, J=8.4Hz, J=1.5Hz, 1H), 7.16(d, J=1.5Hz, 1H), 7.49(d, J=8.4Hz, 1H) 
               
               
                   
                 IR(KBr)3495, 3412, 2959, 2931, 1610, 1568, 1552, 1521, 1499, 1477, 1459, 1400, 1364, 1319, 1270, 1227, 1192, 1161, 1116, 1102, 1090, 
               
               
                   
                 1052, 1019, 942, 833, 817, 588cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 50 
               
               
                   
               
             
            
               
                 I-226 
                 m.p. 154–156° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.33(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 3.90(s, 2H), 4.68(s, 1H), 5.97(s, 1H), 6.45(s, 1H), 6.60(s, 1H), 6.90–6.98(m, 3H), 
               
               
                   
                 7.10(s, 5H), 7.41(d, J=8.1Hz, 1H), 7.53(m, 2H) 
               
               
                   
                 IR(KBr)3462, 3368, 1611, 1550, 1521, 1499, 1472, 1455, 1437, 1401, 1362, 1321, 1293, 1267, 1229, 1187, 1174, 1164, 1118, 1077, 1050, 
               
               
                   
                 1011, 821cm −1   
               
               
                 I-227 
                 m.p. 172–174° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.38(d, J=1.2Hz, 3H), 1.76(s, 3H), 3.44(s, 3H), 3.75(s, 3H), 3.87(d, J=7.8Hz, 2H), 5.08(brs, 1H), 5.26(m, 1H), 6.08(s, 
               
               
                   
                 1H), 6.45(s, 1H), 6.94&amp;7.53(ABq, J=8.7Hz, 4H), 7.11–7.14(m, 2H), 7.62(d, J=8.7Hz, 1H), 8.87(s, 1H) 
               
               
                   
                 IR(KBr)3412, 1613, 1520, 1478, 1458, 1443, 1404, 1360, 1346, 1290, 1270, 1224, 1200, 1171, 1119, 1078, 1054, 945cm −1   
               
               
                 I-228 
                 m.p. 173–175° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.74(s, 3H), 2.10(s, 3H), 2.50–2.61(m, 2H), 3.20(s, 3H), 3.21(s, 3H), 3.37(s, 3H), 3.71(s, 3H), 4.08(t, J=6.8Hz, 
               
               
                   
                 2H), 5.21–5.25(m, 1H), 6.73(s, 1H), 7.03–7.18(m, 2H), 7.23–7.25(m, 2H), 7.37(d, J=8.6Hz, 2H), 7.69(d, J=8.8Hz, 2H) 
               
               
                   
                 IR(KBr)3600–3200(br), 3100–2800(br), 1610, 1527, 1523, 1477, 1432, 1365, 1240, 1172, 1160, 955, 923cm −1   
               
               
                 I-229 
                 m.p. 148–150° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.70(s, 3H), 1.77(s, 3H), 2.09(s, 3H), 2.48–2.62(m, 2H), 3.38(s, 3H), 3.73(s, 3H), 4.09(t, J=7.0Hz, 2H), 4.84(br, 1H), 
               
               
                   
                 5.19–5.22(m, 1H), 5.70(s, 1H), 6.71–6.96(m, 5H), 7.55(d, J=8.2Hz, 2H) 
               
               
                   
                 IR(KBr)3700–3200(br), 3100–2800(br), 1612, 1584, 1560, 1448, 1428, 1390, 1339, 1315, 1284, 1246, 1173, 1160, 1123, 1018, 999cm −1   
               
               
                 I-230 
                 m.p. 194–195° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.10(s, 3H), 2.39(s, 3H), 3.10(s, 3H), 3.21(s, 3H), 3.36(s, 3H), 3.71(s, 3H), 5.13(s, 2H), 6.73(s, 1H), 7.14–7.18(m, 8H), 
               
               
                   
                 7.69(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3600–3200(br), 3100–2800(br), 1516, 1475, 1360, 1332, 1292, 1266, 1228, 1199, 1174, 1151, 1119, 1098, 1084, 1005, 968cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 51 
               
               
                   
               
             
            
               
                 I-231 
                 m.p. 178–180° C. 
               
               
                   
                   1 HNMR(CDCl 3  ) δ 2.09(s, 3H), 2.40(s, 3H), 3.37(s, 3H), 3.72(s, 3H), 4.97(brs, 1H), 5.10(s, 2H), 5.67(br, 1H), 6.70–6.75(m, 2H), 6.86–7.03 
               
               
                   
                 (m, 3H), 7.22–7.26(m, 2H), 7.32–7.34(m, 2H), 7.54(d, J=8.2Hz, 2H) 
               
               
                   
                 IR(KBr)3600–3200(br), 3100–2800(br), 1611, 1519, 1479, 1463, 1388, 1339, 1314, 1286, 1258, 1246, 1225, 1128, 1098, 1077, 1007cm  −1   
               
               
                 I-232 
                 m.p. 177–179° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.54(s, 3H), 2.69(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.15(d, J=8.4Hz, 2H), 7.30–7.49 
               
               
                   
                 (m, 9H), 7.53–7.59(m, 2H) 
               
               
                   
                 IR(CHCl 3 )1516, 1476, 1368, 1266, 1176, 1118, 1077, 1080, 1013, 970, 876, 820cm −1   
               
               
                 I-233 
                 amorphouspowder 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.54(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.67(brs, 1H), 5.90(s, 1H), 6.46(s, 1H), 6.95(d.d, J=1.8&amp;8.1Hz, 1H), 
               
               
                   
                 7.02(d, J=8.1Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.31–7.49(m, 7H), 7.55–7.62(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3526, 1517, 1483, 1414, 1389, 1289, 1246, 1192, 1114, 1070, 1010, 937, 818cm −1   
               
               
                 I-234 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.24(s, 3H), 3.53(s, 3H), 3.79(s, 3H), 3.96(s, 3H), 4.64(d, J=6.9Hz, 2H), 5.49(t,  
               
               
                   
                 J=6.9Hz, 1H), 6.87(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.35(d.d, J=8.4&amp;2.1Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.71(d, J=8.4Hz, 2H), 8.13(d, J=8.4Hz, 
               
               
                   
                 2H) 
               
               
                 I-235 
                   1 HNMR(CDCl 3 ) δ 2.69(s, 3H), 3.14(s, 3H), 3.55(s, 3H), 3.80(s, 3H), 5.20(s, 2H), 6.89(s, 1H), 7.16(d, J=9.0Hz, 1H), 7.34(d, J=2.1Hz, 1H), 
               
               
                   
                 7.36–7.51(m, 6H), 7.75(d, J=8.4Hz, 2H), 8.23(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3427, 1724, 1685, 1606, 1509, 1481, 1369, 1272, 1235, 1179, 1120, 1084, 1017cm −1   
               
               
                 I-236 
                   1 HNMR(CDCl 3 ) δ 3.46(s, 3H), 3.77(s, 3H), 5.16(s, 3H), 6.50(s, 3H), 6.96(dd, J=8.4&amp;2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 
               
               
                   
                 1H), 7.34–7.50(m, 5H), 7.75(d, J=8.1Hz, 2H), 8.17(d, J=8.1Hz, 2H) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 52 
               
               
                   
               
             
            
               
                 I-237 
                   1 HNMR(CDCl 3 ) δ 3.44(s, 3H), 3.76(s, 3H), 3.96(s, 3H), 5.16(s, 2H), 5.69(s, 1H), 5.89(s, 1H), 6.49(s, 1H), 6.96(d.d, J=8..4&amp;2.1Hz, 1H), 
               
               
                   
                 7.03(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.32–7.50(m, 5H), 7.73(d, J=8.4Hz, 2H), 8.13(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3497, 3443, 1708, 1608, 1585, 1487, 1460, 1443, 1395, 1281, 1113, 1068, 1008cm −1   
               
               
                 I-238 
                   1 HNMR(CDCl 3 ) δ 2.69(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.79(s, 3H), 3.96(s, 3H), 5.19(s, 2H), 6.87(s, 1H), 7.15(d, J=9.0Hz, 1H), 7.31–7.50(m, 
               
               
                   
                 7H), 7.71(d, J=8.4Hz, 2H), 8.13(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1719, 1608, 1481, 1366, 1278, 1118, 1080, 1017cm −1   
               
               
                 I-239 
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 2.68(s, 3H), 3.12(s, 3H), 3.53(s, 3H), 3.79(s, 3H), 3.96(s, 3H), 5.14(s, 2H), 6.87(s, 1H), 7.15(d, J=8.7Hz, 
               
               
                   
                 1H), 7.21(d, J=8.4Hz, 2H), 7.34(d, J=8.4Hz, 2H), 7.36(d, J=8.7Hz, 1H), 7.40(d, J=2.1Hz, 1H), 7.71(d, J=8.7Hz, 2H), 8.13(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1718, 1607, 1519, 1481, 1355, 1280, 1232, 1182, 1121, 1079, 1018cm −1   
               
               
                 I-240 
                   1 HNMR(CDCl 3 ) δ 2.70(s, 3H), 3.03(s, 3H), 3.12(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 5.18(s, 2H), 6.78–6.89(broad, 1H), 6.86(s, 1H), 7.14(d, 
               
               
                   
                 J=8.4Hz, 1H), 7.31–7.49(m, 8H), 7.55(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1604, 1526, 1483, 1395, 1374, 1360, 1292, 1231, 1177, 1119, 1078, 1014cm −1   
               
               
                 I-241 
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 2.69(s, 3H), 3.05(s, 3H), 3.12(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 5.14(s, 2H), 6.85(s, 1H), 6.81–6.91(broad, 
               
               
                   
                 2H), 7.14(d, J=8.4Hz, 1H), 7.21(d, J=8.1Hz, 1H), 7.34(d, J=8.1Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.56(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1605, 1529, 1484, 1396, 1356, 1275, 1233, 1178, 1121, 1078, 1016cm −1   
               
               
                 I-242 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.03(s, 6H), 3.22(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.49(t,  
               
               
                   
                 J=6.6Hz, 1H), 6.75–6.91(broad, 2H), 6.86(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.34(d.d, J=8.7&amp;2.1Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.55(d,  
               
               
                   
                 J=8.7Hz, 1H)IR(KBr)1609, 1529, 1482, 1363, 1235, 1178, 1117, 1078, 1013cm −1   
               
               
                 I-243 
                 IR(KBr)3409, 1608, 1509, 1464, 1367, 1230, 1175, 1149, 1079, 1018cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 53 
               
               
                   
               
             
            
               
                 I-244 
                   1 HNMR(CDCl 3 ) δ 1.72(s, 3H), 1.76(s, 3H), 2.55(m, 2H), 3.22(s, 3H)3.45(s, 3H), 3.72(s, 3H), 4.07(d, J=6.6Hz, 2H), 4.46(d, J=10.5Hz, 
               
               
                   
                 1H), 4.51(d, J=10.5Hz, 1H), 4.66(d, J=10.5Hz, 1H), 4.75(d, J=10.5Hz, 1H), 5.24(brs, 1H), 6.84(s, 1H), 6.95(d, J=8.7Hz, 1H), 7.02(s, 1H), 
               
               
                   
                 7.21(d, J=8.7Hz, 1H), 7.39(d, J=9.0Hz, 2H)7.71(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3307, 1609, 1509, 1465, 1364, 1235, 1180, 1152, 1082, 1021cm −1   
               
               
                 I-245 
                 m.p. 182–184° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.42(s, 3H), 2.70(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 5.19(s, 2H)6.86(s, 1H), 7.13–7.53(m, 12H) 
               
               
                   
                 IR(KBr)3434, 3030, 2937, 1605, 1522, 1483, 1366, 1274, 1235, 1176, 1119, 1086, 1011cm −1   
               
               
                 I-246 
                   1 HNMR(CDCl 3 ) δ 2.58(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H)3.91(s, 3H), 5.26(m, 2H), 6.84(s, 1H), 7.12(d, J=9.0Hz, 1H), 7.27–7.54 
               
               
                   
                 (m, 8H), 7.60(d, J=8.7Hz, 2H), 7.90(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr)1728, 1699, 1605, 1513, 1480, 1362, 1239, 1175, 1150, 1083, 1017cm −1   
               
               
                 I-247 
                 IR(KBr)1729, 1607, 1512, 1479, 1366, 1234, 1177, 1151, 1079, 1015cm −1   
               
               
                 I-248 
                   1 H NMR(CDCl 3 ) δ 1.75 (s, 3H), 1.79 (s, 3H), 2.57 (s, 3H), 3.21 (s, 3H), 3.56 (s, 3H), 3.78 (s, 3H), 3.89(s, 3H), 4.63 (d, J=6.6Hz, 
               
               
                   
                 2H), 5.49–5.58 (m, 1H), 6.85 (s, 1H), 6.93–7.00 (m, 3H), 7.38 (d, J=8.7Hz, 2H), 7.70 (d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)1603, 1518, 1482, 1365, 1239, 1176, 1150, 1078cm −1   
               
               
                 I-249 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.30(br, 1H), 2.76–2.82(m, 2H), 3.64–3.68(m, 2H), 3.87(s, 1H), 5.14(s, 2H), 5.70(s, 1H), 6.70(dd, J=2.1, 8.4Hz, 1H), 6.78 
               
               
                   
                 (s, 1H), 6.84(d, J=1.8Hz, 1H), 6.97–7.01(m, 3H), 7.37–7.49(m, 5H), 7.56–7.61(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1608, 1583, 1517, 1464, 1387, 1287, 1247, 1225, 1178, 1082, 1015cm −1   
               
               
                 I-250 
                 m.p. 104–105° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 0.76(t, J=7.5Hz, 3H), 1.44–1.54(m, 2H), 3.61(s, 3H), 3.71(t, J=6.6Hz, 2H), 3.74(s, 3H), 3.87(s, 3H)5.16(s, 2H), 5.63 
               
               
                   
                 (s, 1H), 6.66(s, 1H), 6.90(dd, J=2.1, 8.4Hz, 1H), 6.96–7.01(m, 4H), 7.04(d, J=1.8Hz, 1H), 7.37–7.48(m, 5H), 7.51–7.56(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1608, 1593, 1518, 1474, 1462, 1379, 1294, 1251, 1226, 1183, 1109, 1078, 1040, 1008cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 54 
               
               
                   
               
             
            
               
                 I-251 
                 m.p. 103–105° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 0.78(t, J=7.2Hz, 3H), 1.15–1.27(m, 2H), 1.43–1.51(m, 2H), 3.61(s, 3H), 3.73–3.77(m, 2H), 3.74(s, 3H), 3.87(s, 3H), 5.16 
               
               
                   
                 (s, 2H), 5.63(s, 1H), 6.65(s, 1H), 6.90(dd, J=2.1, 8.1Hz, 1H), 6.96–7.01(m, 3H), 7.04(d, J=2.1Hz, 1H), 7.37–7.48(m, 5H), 7.51–7.56(m, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1607, 1518, 1467, 1375, 1288, 1251, 1179, 1113, 1084, 1020, 1008cm −1   
               
               
                 I-252 
                 m.p. 111.5–112.5° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 0.78(t, J=7.5Hz, 3H), 1.15–1.27(m, 2H), 1.41–1.50(m, 2H), 3.10(s, 3H), 3.61(s, 3H), 3.73–3.78(m, 2H), 3.74(s, 6H), 5.18 
               
               
                   
                 (s, 2H), 6.66(s, 1H), 6.96–7.01(m, 2H), 7.10(d, J=8.7Hz, 1H), 7.26–7.55(m, 9H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1609, 1518, 1464, 1440, 1375, 1355, 1289, 1269, 1249, 1181, 1170, 1107, 1080, 1019cm −1   
               
               
                 I-253 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.45(s, 3H), 3.76(s, 3H), 4.62(d, J=8.4Hz, 2H), 5.54(t, J=8.4Hz, 1H), 6.49(s, 1H), 6.91–6.99 
               
               
                   
                 (m, 2H), 7.05(d, J=1.5Hz), 7.74(d, J=8.7Hz, 2H), 8.15(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3474, 1687, 1607, 1509, 1417, 1397, 1316, 1287, 1240, 1109 1071, 1006cm −1   
               
               
                 I-254 
                   1 HNMR(CDCl 3 ) δ 2.39(s, 3H), 3.45(s, 3H), 3.76(s, 3H), 5.11(s, 2H), 6.49(s, 1H), 6.94(dd, J=8.4&amp;1.8Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.06 
               
               
                   
                 (d, J=1.8Hz), 7.19–7.38(m, 4H), 7.73(d, J=8.4Hz, 2H), 8.14(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3549, 3466, 1668, 1603, 1518, 1489, 1465, 1449, 1421, 1397, 1372, 1288, 1236, 1186, 1117, 1074, 1017cm −1   
               
               
                 I-255 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.02(s, 6H), 3.48(s, 3H), 3.74(s, 3H), 4.61(d, J=7.2Hz, 2H), 5.53(t, J=7.2Hz, 1H), 5.66(s, 1H), 
               
               
                   
                 5.92(s, 1H), 6.47(s, 1H), 6.81(broad, 2H), 6.95(s, 2H), 7.06(s, 1H), 7.56(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3535, 3494, 3452, 1606, 1526, 1487, 1406, 1357, 1288, 1242, 1195, 1112cm −1   
               
               
                 I-256 
                   1 HNMR(CDCl 3 ) δ 2.39(s, 3H), 3.02(s, 6H), 3.48(s, 3H)3.74(s, 3H)5.10(s, 2H), 5.66(s, 1H), 5.93(s, 1H), 6.47(s, 1H), 6.82(d, J=8.4Hz, 
               
               
                   
                 2H), 6.96(dd, J=8.1&amp;1.8Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.08(d, J=1.8Hz, 1H), 7.23(d, J=7.8Hz, 2H), 7.34(d, J=7.8Hz, 2H), 7.56(d, J=8.4Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr)3536, 3379, 1610, 1586, 1528, 1489, 1460, 1443, 1361, 1288, 1250, 1225, 1195, 1117, 1072, 1008cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 55 
               
               
                   
               
             
            
               
                 I-257 
                   1 HNMR(CDCl 3 ) δ 1.71(s, 3H), 1.76(s, 3H), 2.49–2.60(m, 2H), 3.44(s, 3H), 3.70(s, 3H), 4.06(t, J=6.3Hz, 2H), 4.48(d, J=6.0Hz, 2H), 4.71 
               
               
                   
                 (d, J=8.7Hz, 2H), 5.23(t, J=8.7Hz, 1H), 5.37(broads, 1H), 6.84(s, 1H), 6.91–6.97(m, 1H), 6.92(d, J=8.4Hz, 2H), 7.18–7.23(m, 2H), 7.52 
               
               
                   
                 (d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3398, 1612, 1518, 1465, 1389, 1232, 1174, 1131, 1101, 1081, 1023cm −1   
               
               
                 I-258 
                   1 HNMR(CDCl 3 ) δ: 3.21(s, 3H), 3.41(s, 3H), 3.63(s, 3H), 3.77(s, 3H), 4.76(s, 2H), 5.15(s, 2H), 6.94(s, 1H), 6.99(d, J=8.7Hz, 1H), 7.23–7.49 
               
               
                   
                 (m, 9H), 7.71(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3497, 1738, 1721, 1607, 1509, 1469, 1362, 1242, 1152, 1056, 1017cm −1   
               
               
                 I-259 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.35(s, 6H), 2.73(s, 3H), 2.79(t, J=5.7Hz, 2H), 3.21(s, 3H), 3.31(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.19(t, J=5.7Hz, 2H), 
               
               
                   
                 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.34–7.41(m, 4H), 7.66–7.71(m, 2H) 
               
               
                   
                 IR(KBr)3600–2700(br), 1519, 1481, 1365, 1273, 1200, 1177, 1151, 1120, 1079, 1015cm −1   
               
               
                 I-260 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3  + CD 3 OD) δ 2.71(t, J=5.1Hz, 2H), 3.46(s, 6H), 3.73(s, 6H), 4.11(t, J=5.1Hz, 2H), 6.44(s, 1H), 6.87–6.99(m, 4H), 7.04(d, 
               
               
                   
                 J=2.1Hz, 1H), 7.49–7.53(m, 2H) 
               
               
                   
                 IR(KBr)3600–2200(br), 1607, 1583, 1519, 1475, 1407, 1390, 1275, 1252, 1226, 1114, 1062cm −1   
               
               
                 I-261 
                 m.p. 85–87° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.49(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.23(brs, 1H), 5.68(brs, 1H), 5.89(s, 1H), 6.43(s, 1H), 6.95(dd, J=8.3, 2.1Hz, 1H), 
               
               
                   
                 7.03(d, J=8.3Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.08(t, J=8.7Hz, 1H), 7.33(ddd, J=8.7, 2.1, 1.2Hz 1H), 7.37–7.47(m, 6H) 
               
               
                   
                 IR(KBr)3410, 1525, 1488, 1284, 1248, 1102, 1010, 759, 704cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 56 
               
               
                   
               
             
            
               
                 I-262  
                 m.p. 138–140° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.82, (s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.48(s, 3H), 3.78(s, 3H), 4.64(d, J=6.5Hz, 2H), 5.51(t, J=6.5Hz, 1H), 
               
               
                   
                 7.05(d, J=8.5Hz, 1H), 7.08(s, 1H), 7.14(dd, J=8.5, 2.2Hz, 1H), 7.34(d, J=2.2Hz, 1H), 7.40(d, J=8.7Hz, 2H), 7.69(d, J=8.7Hz, 2H), 10.00 
               
               
                   
                 (s, 1H) 
               
               
                   
                 IR(KBr)1693, 1514, 1470, 1361, 1348, 1275, 1239, 1175, 1151, 979, 969, 867, 845, 815cm −1   
               
               
                 I-263 
                 foam 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.74(s, 3H), 1.78(s, 3H), 3.32(s, 3H), 3.44(s, 3H), 3.76(s, 3H), 4.66(d, J=6.6Hz, 2H), 5.49(t, J=6.6Hz, 1H), 7.11(s, 1H), 
               
               
                   
                 7.23–7.25(m, 3H), 7.48(d, J=8.6Hz, 2H), 7.77(d, J=8.6Hz, 2H), 13.1(brs, 1H) 
               
               
                   
                 IR(KBr)3431, 1737, 1518, 1471, 1177, 1151, 972, 864, 849cm −1   
               
               
                 I-264 
                 m.p. 153.5–155.5° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.58(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 5.21(s, 2H), 6.83(s, 1H), 7.04–7.24(m, 5H), 7.30–7.49(m, 5H), 7.56–7.65(m, 2H) 
               
               
                   
                 IR(CHCl 3 )1607, 1520, 1481, 1412, 1368, 1298, 1267, 1131, 1080, 1012, 960, 942, 907, 869, 836, 812cm −1   
               
               
                 I-265 
                 dp &gt; 116° C. 
               
               
                   
                   1 HNMR(CDCl 3  + CD 3 OD) δ 2.69(s, 3H), 3.15(s, 3H), 3.16(s, 3H), 3.57(s, 3H), 3.80(s, 3H), 5.21(s, 2H), 6.88(s, 1H), 7.19(d, J=8.4Hz, 1H), 
               
               
                   
                 7.34–7.51(m, 7H), 7.83–7.90(m, 2H), 8.01–8.07(m, 5H) 
               
               
                   
                 IR(KBr)3434, 3028, 2934, 1596, 1519, 1460, 1365, 1308, 1276, 1173, 1148, 1119, 1108, 1012, 946, 841, 819cm −1   
               
               
                 I-266 
                 m.p. 136–138° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.43(s, 3H), 3.75(s, 3H), 5.19(s, 2H), 5.98(s, 1H), 6.44(s, 1H), 7.04–7.52(m, 10H), 7.57–7.65(m, 5H) 
               
               
                   
                 IR(CHCl 3 )3496, 1612, 1521, 1488, 1454, 1412, 1391, 1313, 1267, 1157, 1113, 1069, 1010, 934, 825cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 57 
               
               
                   
               
             
            
               
                 I-267 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 3.10(s, 3H), 3.21(s, 3H), 3.41(s, 3H), 3.67(s, 3H), 3.77(s, 3H), 5.11(s, 2H), 6.93(s, 1H), 7.09(d, J=8.6Hz, 
               
               
                   
                 1H), 7.21(d, J=8.2Hz, 2H), 7.27(d, J=2.1Hz, 1H), 7.35(d, J=8.2Hz, 2H), 7.38(d, J=8.9Hz, 2H), 7.70(d, J=8.9Hz, 2H) 
               
               
                   
                 IR(KBr)1733, 1518, 1471, 1367, 1297, 1177, 1151, 1118, 1059, 971, 862, 815cm −1   
               
               
                 I-268 
                 amorphous 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.64(s, 3H), 1.70(s, 3H), 2.44(q, J=7.2Hz, 2H), 3.30(s, 3H), 3.70(s, 3H), 3.93(t, J=7.2Hz, 2H), 5.26(t, J=7.2Hz, 1H), 
               
               
                   
                 6.64(dd, J=8.6, 2.1Hz, 1H), 6.74(d, J=2.1Hz, 1H), 6.87(d, J=8.9Hz, 2H), 6.87(d, J=8.6Hz, 1H), 6.96(s, 1H), 7.48(d, J=8.9Hz, 2H), 8.84 
               
               
                   
                 (s, 1H), 9.59(s, 1H), 12.8(brs, 1H) 
               
               
                   
                 IR(CHCl 3 )3594, 3540, 1743, 1707, 1520, 1470, 1260, 1058cm −1   
               
               
                 I-269 
                 m.p. 206–208° C.(dec.) 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.32(s, 3H), 3.32(s, 3H), 3.66(s, 3H), 5.05(s, 2H), 6.66(dd, J=8.2, 2.1Hz, 1H), 6.79(d, J=2.1Hz, 1H), 6.83(s, 1H), 6.84 
               
               
                   
                 (d, J=8.6Hz, 2H), 6.89(d, J=8.2Hz, 1H), 7.20(d, J=8.0Hz, 2H), 7.38(d, J=8.0Hz, 2H), 7.45(d, J=8.6Hz, 2H), 8.91(s, 1H), 9.68(s, 1H), 
               
               
                   
                 12.7(brs, 1H) 
               
               
                   
                 IR(KBr)3413, 1710, 1612, 1591, 1520, 1471, 1377, 1227, 1083, 1059, 1013, 837, 809cm −1   
               
               
                 I-270 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.42(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 5.93(s, 1H), 6.47(s, 1H), 6.96(dd, J=1.8, 8.1Hz, 1H), 7.03 
               
               
                   
                 (d, J=1.8Hz, 1H), 7.25–7.28(m, 2H), 7.35–7.48(m, 5H), 7.52–7.56(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3535, 3014, 1616, 1588, 1559, 1523, 1513, 1490, 1463, 1455, 1417, 1396, 1317, 1290, 1247, 1194, 1115, 1072, 1012cm −1   
               
               
                 I-271 
                 m.p. 143–145° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.70(s, 3H), 3.12(s, 3H), 3.54(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 5.18(s, 2H), 6.83(s, 1H), 7.00–7.07(m, 2H), 7.14(d, J=8.4Hz, 
               
               
                   
                 1H), 7.33–7.49(m, 9H) 
               
               
                   
                 IR(KBr)3434, 2940, 1609, 1520, 1482, 1396, 1369, 1293, 1283, 1243, 1178, 1114, 1080, 1021, 1009cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 58 
               
               
                   
               
             
            
               
                 I-272 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.71(s, 3H), 3.86(s, 3H), 5.15(s, 2H), 5.67(s, 1H), 5.84(s, 1H), 6.42(s, 1H), 6.98(dd, J=1.8, 8.4Hz, 1H),  
               
               
                   
                 7.01–7.07(m, 2H), 7.11(d, J=1.8Hz, 1H), 7.35–7.45(m, 8H) 
               
               
                   
                 IR(CHCl 3 )3534, 3024, 1617, 1587, 1517, 1503, 1483, 1462, 1409, 1290, 1247, 1226, 1215, 1122, 1104, 1072, 1013cm −1   
               
               
                 I-273 
                 m.p. 155–156° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.42(s, 3H), 2.73(s, 3H), 3.23(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.49(m, 
               
               
                   
                 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.25–7.53(m, 6H) 
               
               
                   
                 IR(KBr)3434, 2935, 1605, 1522, 1465, 1388, 1365, 1292, 1273, 1176, 1119, 1084, 1011cm −1   
               
               
                 I-274 
                 m.p. 138–140° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.50(m, 1H), 
               
               
                   
                 6.83(s, 1H), 7.01–7.04(m, 2H), 7.08(d, J=8.4Hz, 1H), 7.26(d, J=0.6Hz, 1H), 7.34–7.43(m, 3H) 
               
               
                   
                 IR(KBr)3433, 2937, 1608, 1519, 1480, 1400, 1368, 1292, 1271, 1244, 1179, 1112, 1081, 1011cm −1   
               
               
                 I-275 
                 m.p. 95–97° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 2.42(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.52(m, 1H), 5.69(s, 1H), 6.47(s, 
               
               
                   
                 1H), 6.95–7.07(m, 3H), 7.25–7.28(m, 2H), 7.52–7.55(m, 2H) 
               
               
                   
                 IR(KBr)3479, 2935, 1613, 1585, 1523, 1509, 1490, 1458, 1415, 1395, 1362, 1315, 1249, 1196, 1112, 1070, 1005cm −1   
               
               
                 I-276 
                 m.p. 155–158° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(d, J=0.9Hz, 3H), 1.82(d, J=0.9Hz, 3H), 3.45(s, 3H), 3.86(s, 3H), 4.61(d, J=6.9Hz, 2H), 5.35(m, 1H), 5.68(s, 1H), 
               
               
                   
                 5.82(s, 1H), 6.42(s, 1H), 6.96–7.09(m, 4H), 7.35–7.41(m, 2H) 
               
               
                   
                 IR(KBr)3428, 3005, 2952, 1613, 1583, 1517, 1505, 1487, 1464, 1451, 1411, 1387, 1359, 1317, 1289, 1245, 1140, 1101, 1070, 1013cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 59 
               
               
                   
               
             
            
               
                 I-277 
                 m.p. 173–175° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.74(s, 3H), 2.42(s, 3H), 2.51–2.60(m, 2H), 2.75(s, 3H), 3.21(s, 3H), 3.53(s, 3H), 3.76(s, 3H), 4.07(t, J=6.9Hz, 
               
               
                   
                 2H), 5.21(m, 1H), 6.86(s, 1H), 7.06(d, J=8.7Hz, 1H), 7.25–7.28(m, 2H), 7.35(dd, J=2.1, 8.7Hz, 1H), 7.40(d, J=2.1Hz, 1H), 7.50–7.53 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(KBr)3434, 2934, 1606, 1523, 1482, 1388, 1369, 1277, 1236, 1177, 1118, 1085, 1012cm −1   
               
               
                 I-278 
                 m.p. 151–154° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.51–2.59(m, 2H), 2.75(s, 3H), 3.21(s, 3H), 3.54(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 4.07 
               
               
                   
                 (t, J=6.9Hz, 2H), 5.21(m, 1H), 6.83(s, 1H), 7.00–7.08(m, 3H), 7.34–7.43(m, 4H) 
               
               
                   
                 IR(KBr)3434, 2935, 1610, 1581, 1522, 1479, 1399, 1362, 1283, 1246, 1180, 1125, 1114, 1082, 1046cm −1   
               
               
                 I-279 
                 m.p. 90–92° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.75(s, 3H), 2.42(s, 3H), 2.49–2.56(m, 2H), 3.45(s, 3H), 3.74(s, 3H), 4.06(t, J=6.6 HZ, 2H), 5.22(m, 1H), 5.67 
               
               
                   
                 (s, 1H), 5.90(s, 1H), 6.46(s, 1H), 6.94–7.06(m, 3H), 7.25–7.28(m, 2H), 7.52–7.55(m, 2H) 
               
               
                   
                 IR(KBr)3529, 3381, 2927, 1616, 1586, 1522, 1490, 1465, 1418, 1398, 1360, 1315, 1289, 1251, 1225, 1192, 1114, 1070, 1011cm −1   
               
               
                 I-280 
                 m.p. 82–84° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.75(s, 3H), 2.49–2.56(m, 2H), 3.45(s, 3H), 3.71(s, 3H), 3.85(s, 3H), 4.06(t, J=6.6Hz, 2H), 5.22(m, 1H), 5.67 
               
               
                   
                 (s, 1H), 5.82(s, 1H), 6.42(s, 1H), 6.92–7.09(m, 5H), 7.35–7.43(m, 2H) 
               
               
                   
                 IR(KBr)3420, 3326, 2935, 1615, 1583, 1518, 1504, 1486, 1466, 1410, 1316, 1289, 1249, 1122, 1101, 1071, 1018cm −1   
               
               
                 I-281 
                 m.p. 166–168° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 2.69(s, 3H), 3.11(s, 3H), 3.54(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 5.14(s, 2H), 6.83(s, 1H), 7.00–7.44(m, 11H) 
               
               
                   
                 IR(KBr)3434, 2941, 1608, 1521, 1498, 1482, 1466, 1397, 1368, 1284, 1243, 1177, 1113, 1079, 1019cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 60 
               
               
                   
               
             
            
               
                 I-282 
                 m.p. 109–111° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.39(s, 3H), 3.45(s, 3H), 3.71(s, 3H), 3.85(s, 3H), 5.10(s, 2H), 5.67(s, 1H), 5.83(s, 1H), 6.42(s, 1H), 6.95–7.41(m, 11H) 
               
               
                   
                 IR(CHCl 3 )3497, 2935, 1610, 1583, 1519, 1499, 1481, 1465, 1399, 1312, 1274, 1245, 1185, 1120, 1102, 1067, 1012cm −1   
               
               
                 I-283 
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 2.68(s, 3H), 3.12(s, 3H), 3.53(s, 1H), 3.77(s, 3H), 5.14(s, 2H), 6.83(s, 1H), 7.10–7.24(m, 5H), 7.33(d, J=8.4Hz, 
               
               
                   
                 1H), 7.34(d, J=8.4Hz, 2H), 7.40(d, J=2.1Hz, 1H)7.56–7.64(m, 2H) 
               
               
                   
                 IR(KBr) 1603, 1520, 1482, 1367, 1297, 1277, 1251, 1232, 1176, 1120, 1084, 1012cm −1   
               
               
                 I-284 
                   1 HNMR(CDCl 3 ) δ 2.39(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.10(s, 2H), 5.68(s, 1H), 5.88(s, 1H), 6.44(s, 1H), 6.95(dd, J=8.4&amp;2.1Hz, 1H), 7.03 
               
               
                   
                 (d, J=8.4Hz, 1H), 7.07(d, J=2.1Hz, 1H), 7.08–7.29(m, 4H), 7.34(d, J=8.4Hz, 2H), 7.56–7.65(m, 2H)s 
               
               
                   
                 IR(KBr)3504, 3330, 1604, 1596, 1490, 1461, 1455, 1424, 1360, 1318, 1242, 1223, 1121, 1071, 1009cm −1   
               
               
                 I-285 
                   1 HNMR(CDCl 3 ) δ 2.69(s, 3H), 3.13(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.05–7.15(m, 1H), 7.15(d, J=8.4Hz, 1H),  
               
               
                   
                 7.30–7.49(m, 10H) 
               
               
                   
                 IR(KBr)1610, 1583, 1517, 1475, 1455, 1359, 1296, 1270, 1239, 1180, 1116, 1088, 1013cm −1   
               
               
                 I-286 
                   1 HNMR(CDCl 3 ) δ 3.47(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 5.89(s, 1H), 6.46(s, 1H), 6.95(dd, J=8.4&amp;2.1Hz, 1H), 7.03(d, J=8.4Hz, 
               
               
                   
                 1H), 7.04–7.12(m, 2H), 7.35–7.51(m, 9H) 
               
               
                   
                 IR(KBr)3543, 3346, 1612, 1586, 1566, 1518, 1502, 1479, 1407, 1362, 1320, 1239, 1110, 1068, 1006cm −1   
               
               
                 I-287 
                   1 HNMR(CDCl 3 ) δ 2.68(s, 3H), 3.14(s, 3H), 3.58(s, 3H), 3.81(s, 3H), 5.20(s, 2H), 6.88(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.32–7.49(m, 7H), 
               
               
                   
                 7.60–7.68(m, 1H), 7.98–8.04(m, 1H), 8.24–8.29(m, 1H), 8.44–8.47(m, 1H) 
               
               
                   
                 IR(KBr)1609, 1531, 1362, 1270, 1239, 1178, 1122, 1085, 1014cm −1   
               
               
                 I-288 
                   1 HNMR(CDCl 3 ) δ 3.49(s, 3H), 3.78(s, 3H), 5.17(s, 2H), 5.71(s, 1H), 5.83(s, 1H), 6.49(s, 1H))6.95(dd, J=12.3&amp;1.2Hz, 1H), 7.02(d, J=12.3Hz, 
               
               
                   
                 1H), 7.08(d, J=1.2Hz, 1H), 7.33–7.50(m, 5H), 7.60–7.68(m, 1H), 7.97–8.06(m, 1H), 8.21–8.27(m, 1H), 8.52(s, 1H) 
               
               
                   
                 IR(KBr)3528, 3358, 1588, 1527, 1499, 1454, 1406, 1348, 1314, 1241, 1122, 1070, 1009cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 61 
               
               
                   
               
             
            
               
                 I-289 
                   1 HNMR(CDCl 3 ) δ 2.68(s, 3H), 3.13(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 5.19(s, 2H), 6.79–6.88(m, 1H), 6.86(s, 1H), 7.02–7.10(m, 2H), 7.15(d, 
               
               
                   
                 J=8.4Hz, 1H), 7.26–7.50(m, 8H) 
               
               
                   
                 IR(KBr)3479, 3388, 1623, 1603, 1518, 1478, 1396, 1358, 1176, 1118, 1081, 1013cm −1   
               
               
                 I-290 
                   1 HNMR(CDCl 3 ) δ 3.11(s, 3H), 3.45(s, 3H), 3.77(s, 3H), 5.17(s, 2H), 6.05(s, 1H), 6.46(s, 1H))7.00–7.18(m, 1H), 7.14(d, J=8.4Hz, 1H), 
               
               
                   
                 7.33–7.50(m, 9H), 7.52(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr)3504, 1612, 1578, 1519, 1498, 1464, 1391, 1355, 1290, 1276, 1239, 1183, 1167, 1107, 1070, 1004cm −1   
               
               
                 I-291 
                   1 HNMR(CDCl 3 +CD 3 OD) δ 3.44(s, 3H), 3.75(s, 3H), 4.74(s, 2H), 5.13(s, 2H), 1H), 6.86–6.95(m, 3H), 6.99(d, J=8.7Hz, 1H), 7.30–7.48(m, 
               
               
                   
                 7H),7.52(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3433, 1707, 1611, 1518, 1473, 1463, 1379, 1250, 1174, 1132, 1089, 1058, 1016cm −1   
               
               
                 I-292 
                   1 HNMR(CDCl 3 +CD 3 OD) δ 3.41(s, 3H), 3.62(s, 3H), 3.75(s, 3H), 4.74(s, 2H), 5.15(s, 2H), 6.87–7.01(m, 4H), 7.30–7.55(m, 9H) 
               
               
                   
                 IR(KBr)3386, 1722, 1611, 1518, 1464, 1343, 1271, 1245, 1233, 1215, 1168, 1082, 1060, 1021cm −1   
               
               
                 I-293 
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 2.69(s, 3H), 3.12(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.14(s, 2H), 6.85(s, 1H), 7.05–7.45(m, 12H) 
               
               
                   
                 IR(KBr)1607, 1584, 1519, 1479, 1401, 1364, 1348, 1280, 1237, 1178, 1164, 1115, 1081, 1016cm −1   
               
               
                 I-294 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 4.36(d, J=2.1Hz, 1H), 4.55(s, 2H), 4.76(d, J=2.1Hz, 1H), 6.45, (s, 1H), 6.92(d, J=8.7Hz, 2H), 
               
               
                   
                 6.99(d, J=8.4Hz, 1H), 7.20(dd, J=1.5and8.4Hz, 1H), 7.11(d, J=1.5Hz, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3425, 1612, 1588, 1523, 1487, 1295, 1268, 1228, 1113, 1069, 825cm −1   
               
               
                 I-295 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.78(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 4.79(d, J=6.6Hz, 2H), 6.21(t, J=6.6Hz, 1H), 6.85(s, 1H), 
               
               
                   
                 7.08(d, J=8.7Hz, 1H), 7.37(dd, J=8.7, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)1632, 1607, 1519, 1482, 1180, 1150, 1079, 1011, 976, 876, 814, 798cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 62 
               
               
                   
               
             
            
               
                 I-296 
                 foam 
               
               
                   
                   1 HNMR(CD 3 OD) δ 3.38(s, 3H), 3.68(s, 3H), 4.12(brs, 2H), 4.65(brs, 2H), 5.01(m, 2H), 6.43(s, 1H), 6.78(dd, J=8.7, 1.8Hz, 1H), 6.85(d, 
               
               
                   
                 J=8.7, 2H), 6.86(d, J=1.8Hz, 1H), 6.94(d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3411, 1612, 1591, 1520, 1485, 1461, 1253, 1223, 1115, 1008, 971, 944, 842, 810, 785cm −1   
               
               
                 I-297 
                 foam 
               
               
                   
                   1 HNMR(CD 3 OD) δ 3.38(s, 3H), 3.68(s, 3H), 4.73(d, J=5.1Hz, 2H), 4.23(d, J=5.1Hz, 2H), 5.83(m, 2H), 6.43(s, 1H), 6.79(dd, J=8.7, 1.8Hz, 1H), 
               
               
                   
                 6.85(d, J=8.7, 2H), 6.86(d, J=1.8 HZ, 1H), 6.94(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3393, 1611, 1588, 1523, 1489, 1460, 1248, 1114, 1071, 1013, 940, 824cm −1   
               
               
                 I-298 
                 foam 
               
               
                   
                   1 HNMR(CD 3 OD) δ 1.77(s, 3H), 3.38(s, 3H), 3.68(s, 3H), 4.00(s, 2H), 5.72(d, J=6.3 HZ, 2H), 5.81(t, J=6.3Hz, 1H), 6.43(s, 1H), 6.79(dd, 
               
               
                   
                 J=8.7, 1.8Hz, 1H), 6.85(d, J=8.7, 2H), 6.85(d, J=1.8Hz, 1H), 6.94(d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3384, 1608, 1585, 1523, 1494, 1457, 1262, 1242, 1227, 1116, 1078, 1008, 985, 822, 781cm −1   
               
               
                 I-299 
                 foam 
               
               
                   
                   1 HNMR(CD 3 OD) δ 1.87(s, 3H), 3.83(s, 3H), 3.68(s, 3H), 4.17(s, 2H), 4.69(d, J=6.6Hz, 2H), 5.68(t, J=6.3 HZ, 1H), 6.43(s, 1H), 6.79(dd, 
               
               
                   
                 J=8.7, 1.8Hz, 1H), 6.85(d, J=8.4, 2H), 6.85(d, J=1.8Hz, 1H), 6.94(d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3350, 3236, 1606, 1589, 1524, 1490, 1463, 1247, 1227, 1079, 1011, 992, 819, 790cm −1   
               
               
                 I-300 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.87(s, 3H), 2.10(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.68(s, 2H), 4.71(d, J=6.0Hz, 2H), 5.77(t, J=6.0Hz, 1H), 6.44(s, 1H), 
               
               
                   
                 6.92(d, J=8.0Hz, 2H), 6.95(m, 2H), 7.07(brs, 1H), 7.53(d, J=6.0Hz, 2H) 
               
               
                   
                 IR(Nujol)3409, 1724, 1612, 1587, 1523, 1489, 1460, 1239, 1114, 1071, 1012, 940, 825, 781cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 63 
               
               
                   
               
             
            
               
                 I-301 
                 foam 
               
               
                   
                   1 HNMR(CD 3 OD) δ 2.93(d, J=2.1Hz, 1H), 3.38(s, 3H), 3.68(s, 3H), 4.06(dd, J=9.9, 7.8 HZ, 1H), 4.20(dd, J=9.9, 3.6Hz, 1H), 4.74(ddd, J=7.8, 
               
               
                   
                 3.6, 2.1Hz, 1H), 6.44(s, 1H), 6.80(dd, J=8.4, 1.8Hz, 1H), 6.85(d, J=8.7, 2H), 6.87(d, J=1.8 HZ, 1H), 6.96(d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(Nujol)3282, 1655, 1612, 1588, 1523, 1489, 1460, 1254, 1226, 1072, 1013, 940, 825cm −1   
               
               
                 I-302 
                 foam 
               
               
                   
                   1 HNMR(CD 3 OD) δ 3.30(s, 3H), 3.68(s, 3H), 4.75(d, J=5.1Hz, 2H), 6.44(s, 1H), 6.80(dd, J=8.4, 1.8Hz, 1H), 6.85(d, J=8.4, 2H), 6.92(d, 
               
               
                   
                 J=1.8Hz, 1H), 6.99(d, J=8.7Hz, 1H), 7.42(t, J=5.1Hz, 1H), 7.46(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(Nujol)3474, 3316, 1678, 1611, 1584, 1523, 1487, 1458, 1268, 1231, 1115, 1171, 1011, 942, 824, 758cm −1   
               
               
                 I-303 
                 foam 
               
               
                   
                   1 HNMR(CD 3 OD) δ 1.24(d, j =7.2Hz, 3H), 3.38(s, 3H), 3.68(s, 3H), 4.12(q, J=7.2Hz, 2H), 4.75(d, J=4.8Hz, 2H), 6.43(s, 1H), 6.80(dd, J=8.4, 
               
               
                   
                 1.8Hz, 1H), 6.85(d, J=8.7, 2H), 6.91(d, J=1.8Hz, 1H), 6.99(d, J=8.4Hz, 2H), 7.46(d, J=8.7Hz, 2H), 7.52(t, J=4.8Hz, 1H) 
               
               
                   
                 IR(Nujol)3306, 1715, 1612, 1587, 1523, 1487, 1460, 1266, 1232, 1115, 1070, 824, 760cm −1   
               
               
                 I-304 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.34(s, 3H), 2.38(s, 3H), 2.70(s, 3H), 3.07(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.13(s, 2H), 6.84(s, 1H), 7.03( 
               
               
                   
                 d, J=7.8Hz, 1H), 7.06(s, 1H), 7.18(d, J=8.4Hz, 1H), 7.28(d, J=7.8Hz, 1H), 7.36(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 
               
               
                   
                 1H), 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)1611, 1518, 1480, 1365, 1177, 1151, 1080, 876, 816cm −1   
               
               
                 I-305 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.25(d, J=6.9Hz, 6H), 2.67(s, 3H), 2.93(q, J=6.9Hz, 1H)3.13(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.15(s, 2H), 
               
               
                   
                 6.84(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.26(d, J=8.4Hz, 2H), 7.34(dd, J=2.4, 8.7Hz, 1H), 7.38(d, J=8.4Hz, 4H), 7.40(d, J=2.4Hz, 1H), 7.68 
               
               
                   
                 (d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1609, 1519, 1481, 1365, 1177, 1151, 1080, 875, 819cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 64 
               
               
                   
               
             
            
               
                 I-306 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.62(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 5.36(s, 2H), 6.84(s, 1H), 7.18(d, J=8.7Hz, 1H), 7.26(s, 1H), 
               
               
                   
                 7.33(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.51(m, 2H), 7.57(dd, J=1.8, 8.4Hz, 1H), 7.68(d, J=8.7Hz, 
               
               
                   
                 2H), 7.84–7.93(m, 4H) 
               
               
                   
                 IR(KBr)1608, 1519, 1480, 1364, 1177, 1151, 1079, 876, 819, 797cm −1   
               
               
                 I-307 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.64(s, 3H), 3.21(s, 3H), 3.28(s, 3H), 3.55(s, 3H), 3.77(s, 3H),5.51(s, 2H), 6.83(s, 1H), 7.18(d, J=8.4Hz, 1H), 7.31(dd, 
               
               
                   
                 J=2.4, 8.4Hz, 1H), 7.37(d, J=8.7Hz, 2H), 7.42(d, J=2.4Hz, 1H), 7.58(dt, J=2.4, 7.2Hz, 1H), 7.67(d, J=8.7Hz, 2H), 7.74(d, J=8.4Hz, 1H), 
               
               
                   
                 7.76(dt, J=2.4, 7.2Hz, 1H), 7.85(d, J=7.2Hz, 1H), 8.06(d, J=7.2Hz, 1H), 8.23(d, J=7.2Hz, 1H) 
               
               
                   
                 IR(KBr)1603, 1519, 1480, 1365, 1177, 1151, 1080, 876, 824, 797cm −1   
               
               
                 I-308 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.76(s, 3H), 3.17(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H),5.25(s, 2H), 6.85(s, 1H), 7.12(d, J=8.7Hz, 1H), 7.35(dd, 
               
               
                   
                 J=2.1, 8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H), 7.61(d, J=8.7Hz, 2H), 7.67(d, J=8.4Hz, 2H), 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1610, 1522, 1489, 1402, 1245, 1181, 1164, 1110, 1071, 821, 805cm −1   
               
               
                 I-309 
                 m.p. 221–222° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.36(s, 3H), 2.38(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 5.09(s, 2H), 6.45(s, 1H), 6.92(d, J=8.4Hz, 2H), 6.98(dd, J=2.1, 8.1Hz, 
               
               
                   
                 1H), 7.06(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.08(s, 1H), 7.28(d, J=8.4Hz, 1H), 7.53(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3475, 1610, 1522, 1489, 1402, 1245, 1181, 1164, 1110, 1071, 821, 805cm −1   
               
               
                 I-310 
                 m.p. 153–155° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.27(d, J=6.9Hz, 6H), 2.95(q, J=6.9Hz, 1H), 3.45(s, 3H), 3.74(s, 3H), 5.11(s, 2H), 6.45(s, 1H), 6.91(d, J=8.4Hz, 2H), 
               
               
                   
                 6.96(dd, J=2.1, 8.1Hz, 1H), 7.03(d, J=8.1Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.28(d, J=8.1Hz, 2H), 7.38(d, J=8.1Hz, 2H), 7.53(d, J=8.4Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr)3486, 1611, 1522, 1489, 1265, 1113, 1072, 1011, 823cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 65 
               
               
                   
               
             
            
               
                 I-311 
                 m.p. 176–177° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 5.32(s, 2H), 6.45(s, 1H), 6.91(d, J=8.4Hz, 2H), 6.97(dd, J=2.1, 8.4Hz, 1H), 7.06(d, J=8.4Hz,  
               
               
                   
                 1H), 7.10(d, J=2.1Hz, 1H), 7.53(d, J=8.4Hz, 2H), 7.50–7.57(m, 3H), 7.82–7.92(m, 4H) 
               
               
                   
                 IR(KBr)3476, 1610, 1522, 1488, 1469, 1401, 1263, 1246, 1173, 1112, 1073, 1014, 1002, 819, 806cm −1   
               
               
                 I-312 
                 m.p. 235–237° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.44(s, 3H), 3.73(s, 3H), 5.49(s, 2H), 6.44(s, 1H), 6.92(d, J=8.4Hz, 2H), 6.93(dd, J=2.1, 8.4Hz, 1H), 7.14(d, J=2.1Hz,  
               
               
                   
                 1H), 7.18(d, J=8.4Hz, 1H), 7.38(d, J=8.4Hz, 1H), 7.52(d, J=8.4Hz, 2H), 7.58(dd, J=7.2, 7.2Hz, 1H), 7.77(dd, J=7.2, 7.2Hz, 1H), 7.85(d,  
               
               
                   
                 J=7.2Hz, 1H), 8.21(d, J=7.2Hz, 1H), 8.22(d, J=7.2Hz, 1H) 
               
               
                   
                 IR(KBr)3378, 1609, 1522, 1488, 1268, 1229, 1205, 1114, 1072, 1016, 825, 782cm −1   
               
               
                 I-313 
                 m.p. 159–161° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 5.22(s, 2H), 6.45(s, 1H), 6.92(d, J=8.4Hz, 2H), 6.96(br.s, 2H), 7.11(br.s, 1H), 7.53(d, J=8.4Hz,  
               
               
                   
                 2H), 7.57(d, J=8.4Hz, 2H), 7.68(d, J=8.4Hz, 2H),  
               
               
                   
                 IR(KBr)3433, 1613, 1523, 1490, 1326, 1251, 1166, 1113, 1066, 1014, 825cm −1   
               
               
                 I-314 
                 m.p. 92–93° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.63(s, 3H), 1.74(s, 3H), 2.34–2.39(m, 1H), 2.67–2.72(m, 2H), 3.47(s, 3H), 3.74(s, 3H), 4.52–4.54(m, 2H), 5.30–5.33 
               
               
                   
                 (m, 2H), 6.78–6.97(m, 4H), 7.20(d, J=7.2Hz, 1H), 7.56(d, J=8.0Hz, 2H) 
               
               
                   
                 IR(KBr)3410, 2932, 1613, 1519, 1473, 1444, 1390, 1263, 1228, 1174cm −1   
               
               
                 I-315 
                 m.p. 85–86° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.83(s, 3H), 2.17–2.40(m, 1H), 2.65–2.71(m, 2H), 3.24(s, 3H), 3.46(s, 3H), 3.80(s, 3H), 4.50–4.52(m, 2H), 
               
               
                   
                 6.70(s, 1H), 7.28–7.43(m, 5H), 7.73(d, J=8.6Hz, 2H) 
               
               
                   
                 IR(KBr)3432, 2938, 1731, 1513, 1469, 1366, 1180, 1151, 970, 868cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 66 
               
               
                   
               
             
            
               
                 I-316 
                 m.p. 179–180° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.72(s, 3H), 1.76(s, 3H), 2.15–2.35(m, 1H), 2.61–2.70(m, 2H), 3.46(s, 3H), 3.76(s, 3H), 4.47–4.50(m, 2H), 6.68(s, 1H), 
               
               
                   
                 7.17–7.52(m, 5H), 7.69(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3427, 2934, 1612, 1576, 1519, 1465, 1443, 1415, 1376, 1228, 1174, 846cm −1   
               
               
                 I-317 
                 m.p. 141–142° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.75(s, 3H), 1.80(s, 3H), 3.21(s, 3H), 3.39(s, 3H), 3.68(s, 3H), 3.77(s, 3H), 4.61(d, J=7.2Hz, 2H), 5.50(t, J=7.0Hz, 1H), 
               
               
                   
                 6.93(s, 1H), 6.99–7.33(m, 5H), 7.57–7.65(m, 2H) 
               
               
                   
                 IR(KBr)3432, 2938, 1724, 1519, 1474, 1365, 1346, 1294, 1262, 1244, 1220, 1163, 1119, 1059, 953, 842, 805cm −1   
               
               
                 I-318 
                 m.p. 127–128° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.74(s, 3H), 2.54(dt, J=4.2, 4.6Hz, 2H), 3.20(s, 3H), 3.39(s, 3H), 3.68(s, 3H), 3.76(s, 3H), 4.05(t, J=4.4Hz,  
               
               
                   
                 2H), 5.21(t, J=4.6Hz, 1H), 6.93(s, 1H), 7.00(d, J=5.6Hz, 1H), 7.11–7.18(m, 2H), 7.25–7.35(m, 3H), 7.61(dd, J=3.8, 5.8Hz) 
               
               
                   
                 IR(KBr)3447, 2974, 2940, 1740, 1519, 1471, 1365, 1343, 1295, 1262, 1226, 1182, 1161, 1119, 1058, 952, 843, 814cm −1   
               
               
                 I-319 
                 m.p. 171–172° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 3.10(s, 3H), 3.39(s, 3H), 3.66(s, 3H), 3.77(s, 3H), 5.11(s, 2H), 6.93(s, 1H), 7.07–7.36(m, 9H), 7.61(dd, J=3.4,  
               
               
                   
                 5.6Hz, 2H) 
               
               
                   
                 IR(KBr)3431, 2937, 1724, 1519, 1474, 1440, 1346, 1296, 1259, 1243, 1222, 1165, 1121, 1060, 953, 843, 804cm −1   
               
               
                 I-320 
                 m.p. 155–156° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.40(s, 3H), 3.69(s, 3H), 3.77(s, 3H), 5.13(s, 2H), 5.70(brs, 1H), 6.82–7.42(m, 5H), 7.39–7.42(m, 5H), 7.62(dd, J=5.4,  
               
               
                   
                 8.6Hz) 
               
               
                   
                 IR(KBr)3550, 3481, 2956, 1723, 1519, 1467, 1435, 1344, 1285, 1261, 1238, 1223, 1130, 1058, 1013, 840cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 67 
               
               
                   
               
             
            
               
                 I-321 
                 m.p. 159–160° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.11(s, 3H), 3.40(s, 3H), 3.66(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 6.93(s, 1H), 7.07–7.49(m, 5H), 7.62(dd, J=3.0, 8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3441, 2952, 1732, 1519, 1469, 1445, 1381, 1356, 1342, 1291, 1273, 1243, 1226, 1162, 1119, 1081, 1057, 999, 950, 842, 805cm −1   
               
               
                 I-322 
                 m.p. 160–161° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 2.93(s, 3H), 3.19(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 5.23(s, 2H), 6.86(s, 1H), 7.20(d, J=8.1Hz,  
               
               
                   
                 2H), 7.30(d, J=8.1Hz, 2H), 7.36–7.41(m, 2H), 7.64–7.70(m, 2H), 7.74(d, J=2.1Hz, 1H), 7.83(d, J=2.1Hz, 1H), 10.16(s, 1H) 
               
               
                   
                 IR(CHCl 3 )3027, 2940, 1692, 1473, 1373, 1227, 1152, 1085cm −1   
               
               
                 I-323 
                 powder 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 2.86(s, 3H), 3.13(s, 3H), 3.21(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 4.64(s, 2H), 5.11(s, 2H), 6.85(s, 1H), 7.21 
               
               
                   
                 (d, J=7.8Hz, 2H), 7.32–7.44(m, 6H), 7.65–7.70(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3026, 2939, 1475, 1372, 1228, 1178, 1151, 1084cm −1   
               
               
                 I-324 
                 powder 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.89–1.98(brs, 1H), 2.39(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.77(s, 2H), 5.01(s, 3H), 5.46(s, 1H), 5.99(s, 1H), 6.45(s, 1H),  
               
               
                   
                 6.45–6.95(m, 2H), 7.05(s, 2H), 7.24(d, J=8.1Hz, 2H), 7.38(d, J=8.1Hz, 2H), 7.50–7.56(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3514, 2937, 1731, 1613, 1522, 1484, 1403, 1228, 1173, 1082cm −1   
               
               
                 I-325 
                 powder 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.31(s, 3H), 2.88(s, 3H), 3.07(s, 3H), 3.22(s, 3H), 3.51(s, 3H), 3.74(s, 3H), 5.23(s, 2H), 6.83(s, 1H), 7.11–7.18(m, 2H),  
               
               
                   
                 7.32–7.41(m, 4H), 7.62–7.68(m, 3H), 8.03(s, 1H) 
               
               
                   
                 IR(CHCl 3 )3026, 2939, 1742, 1472, 1374, 1227, 1179, 1129, 1085cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 68 
               
               
                   
               
             
            
               
                 I-326 
                 powder 
               
               
                   
                   1 HNMR(CD 3 OD) δ 2.33(s, 3H), 3.38(s, 3H), 3.68(s, 3H), 5.11(s, 2H), 6.44(s, 1H), 6.82–6.88(m, 2H), 6.99(d, J=1.8Hz, 1H), 7.13–7.19( 
               
               
                   
                 m, 3H), 7.42–7.50(m, 4H) 
               
               
                   
                 IR(KBr)3411, 2935, 1680, 1611, 1520, 1457, 1404, 1281, 1230, 1114cm −1   
               
               
                 I-327 
                 powder 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.72(s, 3H), 1.79(s, 3H), 3.12(s, 3H), 3.21(s, 3H), 3.27(s, 3H), 3.52(s, 3H), 3.53(s, 3H), 4.81(d, J=7.5Hz, 2H), 5.51(m,  
               
               
                   
                 1H), 7.38–7.43(m, 2H), 7.45–7.50(m, 2H), 7.80(d, J=2.1Hz, 1H), 7.97(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )3032, 2941, 1543, 1377, 1209cm −1   
               
               
                 I-328 
                 m.p. 205–206° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.75(s, 3H), 1.80(s, 3H), 3.41(s, 3H), 3.47(s, 3H), 4.66(d, J=6.6Hz, 2H), 5.06(s, 1H), 5.53(m, 1H), 6.33(s, 1H), 6.89–6.95 
               
               
                   
                 (m, 2H), 7.28–7.34(m, 2H), 7.38–7.40(m, 1H), 7.99(d, J=2.1Hz, 1H), 10.83(d, J=0.6Hz, 1H) 
               
               
                   
                 IR(KBr)3476, 2940, 1614, 1532, 1371, 1238, 1094, 1035cm −1   
               
               
                 I-329 
                 m.p. 144–145° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.83(s, 3H)3.22(s, 3H), 3.28(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 6.86(s, 1H), 7.37–7.45(m, 3H), 7.47–7.53(m, 3H), 7.65–7.70 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(KBr)3434, 3019, 2939, 1515, 1480, 1370, 1176, 1150, 1081cm −1   
               
               
                 I-330 
                 amorphous 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.74(s, 3H), 2.54(q, J=7.2Hz, 2H), 3.21(s, 3H), 3.41(s, 3H), 3.65(s, 3H), 3.77(s, 3H), 4.03(t, J=7.2Hz, 2H), 
               
               
                   
                 5.23(t, J=7.2Hz, 1H), 6.94(s, 1H), 6.98(t, J=8.6Hz, 1H), 7.05(ddd, J=8.6, 2.1, 0.9Hz, 1H), 7.14(dd, J=12.0, 2.1Hz, 1H), 7.38(d, J=8.7Hz,  
               
               
                   
                 2H), 7.71(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(CHCl 3 )1732, 1521, 1471, 1375, 1262, 1230, 1150, 1061, 874cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 69 
               
               
                   
               
             
            
               
                 I-331 
                 m.p. 146–148° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.56(s, 3H), 1.80(s, 3H), 3.21(s, 3H), 3.41(s, 3H), 3.65(s, 3H), 3.77(s, 3H), 4.61(d, J=6.9Hz, 2H), 5.54(t, J=6.9Hz, 1H), 
               
               
                   
                 6.94(s, 1H), 6.98(t, J=8.4Hz, 1H), 7.05(ddd, J=8.4, 2.4, 0.9Hz, 1H), 7.14(dd, J=12.0, 2.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.71(d, J=8.7Hz,  
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr)1736, 1519, 1471, 1357, 1257, 1150, 1061, 984, 872cm −1   
               
               
                 I-332 
                 m.p. 170–171° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.73(s, 3H), 1.77(s, 3H), 3.31(s, 3H), 3.73(s, 3H), 4.62(d, J=7.0Hz, 2H), 5.48(t, J=7.0Hz, 1H), 6.87(d, J=8.9Hz, 2H), 
               
               
                   
                 7.00(s, 1H), 7.03(ddd, J=8.7, 2.3, 0.9Hz, 1H), 7.10(dd, J=12.3, 2.3Hz, 1H), 7.18(t, J=8.7Hz, 1H), 7.48(d, J=8.9Hz, 2H), 9.60(s, 1H), 12.9 
               
               
                   
                 (brs, 1H) 
               
               
                   
                 IR(KBr)3258, 1687, 1615, 1523, 1465, 1373, 1260, 1233, 1057, 994, 835, 823cm −1   
               
               
                 I-333 
                 m.p. 172–174° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.21(s, 3H), 3.41(s, 3H), 3.61(s, 3H), 3.77(s, 3H), 5.17(s, 2H), 6.94(s, 1H), 7.01–7.04(m, 2H), 7.13–7.18(m, 1H), 7.33–7.49 
               
               
                   
                 (m, 7H), 7.70(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)1725, 1522, 1463, 1346, 1261, 1230, 1147, 1058, 878, 756cm −1   
               
               
                 I-334 
                 m.p. 149–151° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.36(s, 3H), 3.21(s, 3H), 3.41(s, 3H), 3.61(s, 3H), 3.77(s, 3H), 5.13(s, 2H), 6.93(s, 1H), 7.00–7.03(m, 2H), 7.12–7.17( 
               
               
                   
                 m, 1H), 7.20(d, J=8.4Hz, 2H), 7.35(d, J=8.4Hz, 2H), 7.38(d, J=8.7Hz, 2H), 7.70(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)1731, 1519, 1472, 1370, 1298, 1152, 1058, 874, 791cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 70 
               
               
                   
               
             
            
               
                 I-335 
                 m.p. 173–174° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.64(s, 3H), 1.70(s, 3H), 2.45(q, J=6.9Hz, 2H), 3.31(s, 3H), 3.73(s, 3H), 4.04(t, J=6.9Hz, 2H), 5.22(t, J=6.9Hz, 1H), 
               
               
                   
                 6.87(d, J=8.7Hz, 2H), 6.99(s, 1H), 7.03(ddd, J=8.7, 2.1, 0.9Hz, 1H), 7.10(dd, J=12.3, 2.1Hz, 1H), 7.16(t, J=8.7Hz, 1H), 7.48(d, J=8.7Hz, 2H), 
               
               
                   
                 9.61(s, 1H), 12.9(brs, 1H) 
               
               
                   
                 IR(KBr)3303, 1696, 1523, 1473, 1371, 1261, 1241, 1061, 1009, 839cm −1   
               
               
                 I-336 
                 m.p. 222–224° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.31(s, 3H), 3.73(s, 3H), 5.20(s, 2H), 6.87(d, J=8.7Hz, 2H), 7.00(s, 1H), 7.03–7.07(m, 1H), 7.13(dd, J=12.3, 2.1Hz, 
               
               
                   
                 1H), 7.26(t, J=8.7Hz, 1H), 7.36–7.52(m, 7H), 9.61(s, 1H), 12.9(brs, 1H) 
               
               
                   
                 IR(KBr)3268, 1689, 1523, 1465, 1374, 1261, 1055, 836cm −1   
               
               
                 I-337 
                 m.p. 205–206° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.32(s, 3H), 3.31(s, 3H), 3.72(s, 3H), 5.15(s, 2H), 6.87(d, J=8.7Hz, 2H), 6.99(s, 1H), 7.04(ddd, J=9.0, 1.9, 0.9Hz, 
               
               
                   
                 1H), 7.12(dd, J=12.3, 1.9Hz, 1H), 7.23(d, J=8.0Hz, 2H), 7.24(t, J=9.0Hz, 1H), 7.38(d, J=8.0Hz, 2H), 7.48(d, J=8.7Hz, 2H), 9.60(s, 1H), 
               
               
                   
                 12.9(brs, 1H) 
               
               
                   
                 IR(KBr)3303, 1696, 1523, 1464, 1261, 1241, 1056, 993, 838, 811, 791cm −1   
               
               
                 I-338 
                 m.p. 120–121° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.13(s, 3H), 3.50(s, 3H), 3.78(s, 3H), 5.08(s, 1H), 5.20(s, 2H), 6.90(m, 2H), 7.09(s, 1H), 7.15–7.19(m, 3H), 7.37–7.50( 
               
               
                   
                 m, 5H), 7.56(dd, J=10.8, 2.1Hz, 1H), 7.64(d, J=2.4Hz, 1H), 9.90(s, 1H) 
               
               
                   
                 IR(KBr)3460, 2934, 1694, 1609, 1585, 1518, 1467, 1442, 1348, 1295, 1273, 1255, 1238, 1171, 1123, 1075, 1003, 960, 828, 807, 755, 700, 
               
               
                   
                 653, 582, 522cm −1   
               
               
                 I-339 
                 m.p. 256–258° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.34(s, 3H), 3.35(s, 3H), 3.72(s, 3H), 5.28(s, 2H), 6.75(d, J=8.1Hz, 2H), 7.05–7.11(m, 3H), 7.36–7.45(m, 4H), 7.53 
               
               
                   
                 (d, J=8.1Hz, 2H), 7.60–7.66(m, 2H), 9.44(s, 1H), 12.84(s, 1H) 
               
               
                   
                 IR(KBr)3459, 2940, 2563, 1706, 1612, 1522, 1469, 1349, 1294, 1258, 1185, 1114, 1082, 1063, 1000, 961, 919, 827, 756, 699, 524cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 71 
               
               
                   
               
             
            
               
                 I-340 
                 m.p. 165–166° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.14(s, 3H), 3.19(s, 3H), 3.51(s, 3H), 3.76(s, 3H), 5.21(s, 2H), 7.11(s, 1H), 7.17(d, J=8.4Hz, 1H), 7.29–7.50(m, 9H), 7.57 
               
               
                   
                 (dd, J=8.1, 2.1Hz, 1H), 7.65(d, J=2.1Hz, 1H), 10.02(s, 1H) 
               
               
                   
                 IR(CHCl 3 )2938, 2844, 1698, 1613, 1590, 1515, 1469, 1372, 1331, 1293, 1255, 1174, 1150, 1122, 1092, 1005, 969, 873, 816cm −1   
               
               
                 I-341 
                 m.p. 195–197° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.13(s, 3H), 3.18(s, 3H), 3.47(s, 3H), 3.77(s, 3H), 5.20(s, 2H), 6.97(s, 1H), 7.17(d, J=8.7Hz, 1H), 7.30–7.50(m, 9H), 7.58 
               
               
                   
                 (dd, J=8.7, 1.8Hz, 1H), 7.67(d, J=1.8Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )2938, 1740, 1707, 1601, 1516, 1472, 1371, 1293, 1260, 1174, 1149, 1117, 1082, 1060, 1002, 971, 875cm −1   
               
               
                 I-342 
                 m.p. 207–209° C. 
               
               
                   
                   1 HNMR(CD 3 OD) δ 3.40(s, 3H), 3.72(s, 3H), 5.21(s, 2H), 6.76–6.78(m, 2H), 6.97(s, 1H), 7.01–7.17(m, 4H), 7.31–7.52(m, 6H) 
               
               
                   
                 IR(KBr)3366, 1705, 1612, 1591, 1522, 1473, 1434, 1375, 1253, 1234, 1130, 1084, 1061, 998, 918, 864, 835, 813, 792, 743, 697, 648, 526cm −1   
               
               
                 I-343 
                 m.p. 206–208° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.14(s, 3H), 3.48(s, 3H), 3.72(s, 3H), 5.20(s, 2H), 5.48(br, 1H), 6.85–6.89(m, 3H), 7.15–7.19(m, 3H), 7.37–7.51(m, 8H), 
               
               
                   
                 7.56(dd, J=8.4, 2.4Hz, 1H), 7.68(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )3320, 2938, 1612, 1520, 1474, 1371, 1292, 1257, 1172, 1120, 1090, 1005, 972, 857, 837, 818cm −1   
               
               
                 I-344 
                 m.p. 187–190° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.33(s, 3H), 3.13(s, 3H), 3.50(s, 3H), 3.76(s, 3H), 5.20(s, 2H), 7.10(s, 1H), 7.15–7.19(m, 3H), 7.28–7.50(m, 7H), 7.56( 
               
               
                   
                 dd, J=8.7, 2.4Hz, 1H), 7.64(d, J=2.4Hz, 1H), 9.93(s, 1H) 
               
               
                   
                 IR(CHCl 3 )2930, 2836, 1750, 1695, 1588, 1513, 1465, 1369, 1329, 1220, 1166, 1122, 1091, 1003, 962, 912, 848, 813cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 72 
               
               
                   
               
             
            
               
                 I-345 
                 m.p. 218–220° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.29(s, 3H), 3.36(s, 3H), 3.37(s, 3H), 3.76(s, 3H), 5.29(s, 2H), 7.11–7.16(m, 3H), 7.31–7.46(m, 6H), 7.52–7.55(m, 
               
               
                   
                 2H), 7.62–7.68(m, 2H), 13.00(br, 1H) 
               
               
                   
                 IR(KBr)3433, 2940, 2600, 1757, 1713, 1652, 1611, 1518, 1471, 1365, 1295, 1260, 1216, 1200, 1171, 1117, 1082, 1061, 1022, 998, 975, 916, 
               
               
                   
                 897, 829, 804, 735, 697, 525cm −1   
               
               
                 I-346 
                 m.p. 206–208° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.31(s, 3H), 3.13(s, 3H), 3.45(s, 3H), 3.58(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.95(s, 1H), 7.08–7.16(m, 3H), 7.34–7.50( 
               
               
                   
                 m, 7H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.67(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )2939, 1732, 1613, 1599, 1518, 1468, 1371, 1290, 1169, 1117, 1081, 1064, 1004, 972, 961, 905, 847, 828cm −1   
               
               
                 I-347 
                 m.p. 201–203° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.76(s, 3H), 3.34(s, 3H), 3.63(s, 3H), 4.51(d, J=4.2Hz, 2H), 5.49(t, J=4.6Hz, 1H), 6.66(s, 1H), 6.76(s, 
               
               
                   
                 2H), 6.86(s, 1H), 7.23–7.29(m, 2H), 7.62–7.66(m, 2H) 
               
               
                   
                 IR(KBr)3431, 2935, 1575, 1516, 1462, 1444, 1421, 1397, 1375, 1224, 1159, 1063, 837cm −1   
               
               
                 I-348 
                 m.p. 265–266° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.31(s, 3H), 3.33(s, 3H), 3.62(s, 3H), 5.03(s, 2H), 6.66(s, 1H), 6.72–6.90(m, 4H), 7.18–7.28(m, 3H), 7.38(d, J=5.2Hz, 
               
               
                   
                 2H), 7.64(dd, J=4.0, 5.4Hz, 2H) 
               
               
                   
                 IR(KBr)3428, 2925, 1575, 1516, 1463, 1442, 1396, 1374, 1248, 1221, 1129, 1087, 1068cm −1   
               
               
                 I-349 
                 m.p. 262–263° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.64(s, 3H), 1.70(s, 3H), 2.43(dt, J=4.6, 5.0Hz, 2H), 3.34(s, 3H), 3.62(s, 3H), 3.91(t, J=4.8Hz, 2H), 5.25(t, J=4.6Hz, 
               
               
                   
                 1H), 6.70(s, 1H), 6.75(s, 2H), 6.87(s, 1H), 7.23–7.29(m, 2H), 7.64(dd, J=2.0, 5.8Hz, 2H) 
               
               
                   
                 IR(KBr)3430, 2934, 1575, 1516, 1464, 1443, 1422, 1398, 1375, 14246, 1225, 1065, 1015cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 73 
               
               
                   
               
             
            
               
                 I-350 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(d, J=0.6Hz, 3H), 2.54(s, 3H), 2.73(s, 3H), 3.23(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 4.63(d, J=6.6Hz, 2H), 
               
               
                   
                 5.49(m, 1H), 6.85(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.30–7.40(m, 4H), 7.53–7.59(m, 2H) 
               
               
                   
                 IR(CHCl 3 )2936, 1606, 1515, 1475, 1366, 1116, 1078, 970, 875, 820cm −1   
               
               
                 I-351 
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.48–2.60(m, 5H), 2.75(s, 3H), 3.21(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 4.07(t, J=6.9Hz,  
               
               
                   
                 2H), 5.21(m, 1H), 6.85(s, 1H), 7.07(d, J=8.7Hz, 1H), 7.30–7.42(m, 4H), 7.53–7.59(m, 2H) 
               
               
                   
                 IR(CHCl 3 )2928, 1607, 1517, 1476, 1367, 1267, 1118, 1080, 1014, 971, 892, 822cm −1   
               
               
                 I-352 
                 m.p. 201–203° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.35(s, 3H), 3.75(s, 3H), 3.76(s, 3H), 5.26(s, 2H), 6.79–6.83(m, 2H), 6.97(s, 1H), 7.01(s, 1H), 7.31–7.54(m, 10H), 9.45 
               
               
                   
                 (s, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1610, 1525, 1492, 1462, 1377, 1337, 1298, 1208, 1171, 1114, 1054, 1031cm −1   
               
               
                 I-353 
                 m.p. 141–143° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.56(s, 3H), 3.78(s, 3H), 3.80(s, 3H), 4.86(s, 1H), 5.26(s, 2H), 6.88–6.92(m, 2H), 6.92(s, 1H), 6.93(s, 1H), 7.24–7.29( 
               
               
                   
                 m, 2H), 7.36–7.41(m, 1H), 7.45–7.50(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1612, 1524, 1491, 1463, 1448, 1378, 1263, 1205, 1177, 1153, 1071, 1053, 1026cm −1   
               
               
                 I-354 
                 m.p. 115–115.5° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.19(s, 3H), 3.56(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 5.27(s, 2H), 6.93(s, 1H), 6.94(s, 1H), 7.25–7.27(m, 2H), 7.32–7.40( 
               
               
                   
                 m, 3H), 7.60–7.64(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1524, 1492, 1463, 1379, 1266, 1210, 1174, 1154, 1126, 1082, 1053, 1029cm −1   
               
               
                 I-355 
                 m.p. 139–140° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(d, J=0.6Hz, 3H), 1.81(d, J=0.9Hz, 3H), 3.82(s, 6H), 4.64(d, J=6.9Hz, 2H), 5.52–5.57(m, 1H), 6.95(s, 1H), 6.97( 
               
               
                   
                 s, 1H), 7.04(t, J=8.4Hz, 1H), 7.26–7.31(m, 1H), 7.37(dd, J=2.1, 12.6Hz, 1H), 7.73–7.77(m, 2H), 8.26–8.31(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1593, 1524, 1508, 1486, 1464, 1380, 1355, 1278, 1264, 1211, 1054, 1029cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 74 
               
               
                   
               
             
            
               
                 I-356 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.68(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.83(s, 1H), 7.10–7.19(m, 3H), 7.30–7.50(m, 7H), 7.56–7.64 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(KBr)1607, 1520, 1482, 1365, 1232, 1177, 1119, 1082, 1013cm −1   
               
               
                 I-357 
                   1 HNMR(CDCl 3 ) δ 2.39(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 5.11(s, 2H), 5.67(s, 1H), 5.88(s, 1H), 6.46(s, 1H), 6.95(d.d, J=8.7&amp;1.8Hz, 1H), 
               
               
                   
                 7.02–7.11(m, 1H), 7.03(d, J=8.7Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.22(d, J=8.7Hz, 2H), 7.34(d, J=8.7Hz, 2H), 7.36–7.47(m, 3H)IR(KBr) 
               
               
                   
                 3546, 3511, 1611, 1586, 1517, 1478, 1405, 1360, 1318, 1240, 1109, 1068, 1007cm −1   
               
               
                 I-358 
                   1 HNMR(CDCl 3 ) δ 3.03(s, 6H), 3.48(s, 3H), 3.77(s, 3H), 5.15(s, 2H), 5.71(s, 1H), 6.73(dd, J=8.7&amp;1.8Hz, 1H), 6.82(d, J=8.4Hz, 2H), 6.97 
               
               
                   
                 (d, J=1.8Hz, 1H), 6.98(dJ=8.7Hz, 1H), 7.11(s, 1H), 7.33–7.48(m, 5H), 7.56(d, J=8.7Hz, 2H), 9.92(s, 1H) 
               
               
                   
                 IR(KBr)3524, 3447, 1697, 1612, 1586, 1525, 1468, 1364, 1283, 1257, 1230, 1201, 1127, 1103, 1073, 1020cm −1   
               
               
                 I-359 
                   1 HNMR(CDCl 3 ) δ 3.04(s, 6H), 3.14(s, 3H), 3.48(s, 3H), 3.76(s, 3H), 5.17(s, 2H), 6.84(d, J=8.7Hz, 2H), 7.06–7.17(m, 3H), 7.34(d, J=1.8Hz, 
               
               
                   
                 1H), 7.35–7.50(m, 6H), 7.55(d, J=8.7Hz, 2H), 10.08(s, 1H) 
               
               
                   
                 IR(KBr)1698, 1610, 1527, 1470, 1357, 1290, 1232, 1183, 1115, 1083, 1018cm −1   
               
               
                 I-360 
                   1 HNMR(CDCl 3 ) δ 2.56(s, 3H), 3.02(s, 6H), 3.54(s, 3H), 3.76(s, 3H), 5.16(s, 2H), 5.67(s, 1H), 6.80(d, J=8.4Hz, 2H), 6.85(s, 1H), 6.91(d. 
               
               
                   
                 d, J=8.4&amp;2.1Hz, 1H), 7.01(d, J=8.4Hz, 1H), 7.05(d, J=2.1Hz, 1H), 7.30–7.47(m, 5H), 7.55(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3542, 3436, 1605, 1530, 1483, 1391, 1360, 1287, 1253, 1234, 1169, 1074, 1016cm −1   
               
               
                 I-361 
                   1 HNMR(CDCl 3 ) δ 1.31(d, J=6.9Hz, 6H), 2.57(s, 3H), 2.97(quint, J=6.9Hz, 1H), 3.54(s, 3H), 3.76(s, 3H), 5.17(s, 2H), 5.68(s, 1H), 6.86( 
               
               
                   
                 s, 1H), 6.92(dd, J=8.4&amp;2.1Hz, 1H), 7.02(d, J=8.4Hz, 1H), 7.05(d, J=2.1Hz, 1H), 7.31(d, J=8.1Hz, 2H), 7.34–7.46(m, 5H), 7.55(d, J=8.1Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr)3446, 1606, 1585, 1522, 1484, 1457, 1394, 1356, 1289, 1257, 1228, 1172, 1076, 1018, 1007cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 75 
               
               
                   
               
             
            
               
                 I-362 
                   1 HNMR(CDCl 3 ) δ 1.31(d, J=6.9Hz, 6H), 2.98(quint, J=6.9Hz, 1H), 3.46(s, 3H), 3.74(s, 3H), 5.15(s, 2H), 5.67(s, 1H), 5.92(s, 1H), 6.48 
               
               
                   
                 (s, 1H), 6.97(dd, J=8.4&amp;1.8Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.10(d, J=1.8Hz, 1H), 7.25(s, 1H), 7.31(d, J=7.8Hz, 2H), 7.34–7.49(m, 5H), 7.57 
               
               
                   
                 (d, J=7.8Hz, 2H) 
               
               
                   
                 IR(KBr)3538, 3505, 3465, 1610, 1586, 1552, 1518, 1584, 1458, 1398, 1281, 1288, 1245, 1198, 1112, 1071, 1002cm −1   
               
               
                 I-363 
                   1 HNMR(CDCl 3 ) δ 2.66(s, 3H), 3.06(s, 3H), 3.13(s, 3H), 3.57(s, 3H), 3.67(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.44(s 1H), 6.85(s, 1H), 7.15 
               
               
                   
                 (d, J=8.7Hz, 1H), 7.28–7.51(m, 10H) 
               
               
                   
                 IR(KBr)3443, 1604, 1518, 1479, 1364, 1237, 1177, 1153, 1118, 1078, 1014cm −1   
               
               
                 I-364 
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.70(s, 3H), 3.06(s, 3H), 3.24(s, 3H), 3.58(s, 3H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.49(t, J= 
               
               
                   
                 6.6Hz, 1H), 6.42(s, 1H), 6.85(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.28–7.49(m, 5H) 
               
               
                   
                 IR(KBr)3432, 3285, 1604, 1518, 1479, 1364, 1328, 1291, 1269, 1237, 1177, 1154, 1117, 1078cm −1   
               
               
                 I-365 
                   1 HNMR(CDCl 3 ) δ 1.57(s, 3H), 1.67(s, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.70(s, 3H), 2.96(s, 3H), 3.24(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 4.32 
               
               
                   
                 (d, J=7.2Hz, 2H), 4.64(d, J=6.9Hz, 2H), 5.25(t, J=6.9Hz, 1H), 5.49(t, J=7.2Hz, 1H), 6.85(s, 1H), 7.09(d, J=8.7Hz, 1H), 7.31–7.41(m, 3H), 
               
               
                   
                 7.44–7.64(m, 3H) 
               
               
                   
                 IR(KBr)3433, 1600, 1517, 1474, 1365, 1339, 1237, 1178, 1153, 1118, 1078, 1014cm −1   
               
               
                 I-366 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.08(s, 3H), 348(s, 3H), 3.75(s, 311), 4.62(d, J=7.2Hz, 2H), 5.54(t, J=7.2Hz, 1H), 5.70(s, 1H), 
               
               
                   
                 5.85(s, 1H), 6.40(s, 1H), 6.46(s, 1H), 6.89–7.00(m, 2H), 7.05(d, J=1.5Hz, 1H), 7.43–7.51(m, 3H) 
               
               
                   
                 IR(KBr)3437, 1605, 1585, 1518, 1482, 1386, 1323, 1243, 1152, 1114, 1071, 1002cm −1   
               
               
                 I-367 
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 3.21(s, 3H), 3.47(s, 3H), 3.64(s, 3H), 3.77(s, 3H), 3.84(s, 3H), 5.17(s, 2H), 6.63(s, 1H), 6.78(s, 1H), 7.10(s, 
               
               
                   
                 1H), 7.20(d, J=8.1Hz, 2H), 7.40(d, J=8.1Hz, 2H), 7.41(d, J=9.3Hz, 2H), 7.70(d, J=9.3Hz, 2H) 
               
               
                   
                 IR(KBr)1702, 1607, 1589, 1518, 1468, 1356, 1216, 1151, 1067, 1039, 1018cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 76 
               
               
                   
               
             
            
               
                 I-368 
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 3.21(s, 3H), 3.48(s, 6H), 3.65(s, 3H), 3.73(s, 3H), 3.83(s, 3H), 4.32(d, J=11.4Hz, 1H), 4.51(d, J=11.4Hz, 1H), 
               
               
                   
                 5.17(s, 2H), 6.93(s, 1H), 6.71(s, 1H), 6.88(s, 1H), 7.21(d, J=8.4Hz, 2H), 7.32–7.41(m, 4H), 7.73(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3514, 1608, 1516, 1465, 1355, 1215, 1149, 1076, 1039, 1017cm −1   
               
               
                 I-369 
                 m.p. 125–127° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.60(s, 3H), 3.52(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 5.20(s, 2H), 6.83(s, 1H), 7.00–7.48(m, 12H) 
               
               
                   
                 IR(KBr)3434, 2943, 1611, 1580, 1520, 1498, 1480, 1398, 1297, 1268, 1245, 1179, 1129, 1079, 1009cm −1   
               
               
                 I-370 
                 m.p. 137–139° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.43(s, 3H), 3.71(s, 3H), 3.85(s, 3H), 5.19(s, 2H), 5.92(s, 1H), 6.43(s, 1H), 7.01–7.51(m, 12H) 
               
               
                   
                 IR(KBr)3391, 2937, 1615, 1583, 1520, 1503, 1482, 1464, 1405, 1359, 1314, 1292, 1273, 1239, 1121, 1108, 1069, 1005cm −1   
               
               
                 I-371 
                 m.p. 92–94° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.70(s, 3H), 3.53(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.53(m, 1H), 6.84(s, 
               
               
                   
                 1H), 7.00–7.45 (m, 7H) 
               
               
                   
                 IR(KBr)3433, 2938, 1609, 1581, 1523, 1499, 1480, 1401, 1368, 1297, 1268, 1240, 1178, 1118, 1079, 1021cm −1   
               
               
                 I-372 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.74(d, J=0.6Hz, 3H), 2.50–2.59(m, 2H), 2.71(s, 3H), 3.53(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 4.04(t, J=7.2Hz, 
               
               
                   
                 2H), 5.23(m, 1H), 6.83(s, 1H), 7.00–7.42(m, 7H) 
               
               
                   
                 IR(CHCl 3 )3011, 2938, 1612, 1581, 1522, 1500, 1480, 1465, 1398, 1370, 1301, 1268, 1238, 1209, 1176, 1119, 1081, 1017cm −1   
               
               
                 I-373 
                 m.p. 95–98° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(s, 3H), 3.43(s, 3H), 3.72(s, 3H), 3.85(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.56(m, 1H), 5.92(s, 1H), 6.43(s, 
               
               
                   
                 1H), 7.01–7.42(m, 7H) 
               
               
                   
                 IR(KBr)3318, 2937, 1612, 1598, 1500, 1485, 1464, 1450, 1361, 1298, 1275, 1240, 1104, 1072, 1011cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 77 
               
               
                   
               
             
            
               
                 I-374 
                 m.p. 69–71° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.74(d, J=0.6Hz, 3H), 2.50–2.60(m, 2H), 3.43(s, 3H), 3.71(s, 3H), 3.85(s, 3H), 4.04(t, J=7.2Hz, 2H), 5.23(m, 
               
               
                   
                 1H), 5.91(s, 1H), 6.43(s, 1H), 7.00–7.42(m, 7H) 
               
               
                   
                 IR(KBr)3385, 2933, 1611, 1583, 1521, 1503, 1485, 1466, 1403, 1358, 1299, 1276, 1241, 1122, 1104, 1071, 1011cm −1   
               
               
                 I-375 
                 m.p. 105–107° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.36(s, 3H), 2.59(s, 3H), 3.52(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 5.16(s, 2H), 6.83(s, 1H), 7.00–7.42(m, 11H) 
               
               
                   
                 IR(KBr)3433, 2940, 1609, 1581, 1522, 1499, 1481, 1461, 1401, 1366, 1296, 1269, 1240, 1178, 1117, 1079, 1021, 1011cm −1   
               
               
                 I-376 
                 m.p. 142–144° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 3.42(s, 3H), 3.71(s, 3H), 3.85(s, 3H), 5.14(s, 2H), 5.91(s, 1H), 6.43(s, 1H), 7.01–7.42(m, 11H) 
               
               
                   
                 IR(KBr)3367, 2936, 1615, 1583, 1520, 1502, 1482, 1464, 1447, 1405, 1359, 1317, 1291, 1274, 1239, 1121, 1109, 1070, 1009cm −1   
               
               
                 I-377 
                 m.p. 174–176° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.21(s, 3H), 3.41(s, 3H), 3.63(s, 3H), 3.77(s, 3H), 5.30(s, 2H), 6.94(s, 1H), 7.03–7.05(m, 2H), 7.15–7.20(m, 1H), 7.25 
               
               
                   
                 (m, 1H), 7.38(d, J=8.9Hz, 2H), 7.62(d, J=7.8Hz, 1H), 7.71(d, J=8.9Hz, 2H), 7.76(dt, J=7.8, 1.5Hz, 1H), 8.60(m, 1H) 
               
               
                   
                 IR(KBr)1732, 1523, 1474, 1368, 1148, 1061, 863, 845, 790cm −1   
               
               
                 I-378 
                 m.p. &gt;260° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.32(s, 3H), 3.73(s, 3H), 5.28(s, 2H), 6.87(d, J=8.7Hz, 2H), 7.00(s, 1H), 7.04(dd, J=8.9, 1.8Hz, 1H), 7.16(dd, J=12.3, 
               
               
                   
                 1.8Hz, 1H), 7.26(t, J=8.9Hz, 1H), 7.39(m, 1H), 7.57(d, J=8.7Hz, 2H), 7.58(d, J=7.8Hz, 1H), 7.89(dt, J=7.8, 1.5Hz, 1H), 8.61(m, 1H), 
               
               
                   
                 9.61(s, 1H), 12.9(brs, 1H) 
               
               
                   
                 IR(KBr)3383, 1735, 1705, 1610, 1522, 1471, 1272, 1226, 1059, 1014, 838, 762cm −1   
               
               
                 I-379 
                 m.p. 137–138° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.79(s, 3H), 4.64(d, J=4.6Hz, 1H), 5.56(t, J=4.6Hz, 1H), 6.92–7.20(m, 6H), 7.61 
               
               
                   
                 (dd, J=3.6, 5.8Hz, 2H), 9.96(Brs, 1H) 
               
               
                   
                 IR(KBr)3434, 2966, 2935, 2839, 1702, 1695, 1521, 1466, 1378, 1299, 1287, 1272, 1240, 1012, 840cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 78 
               
               
                   
               
             
            
               
                 I-380 
                 m.p. 98–99° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 3.45(s, 3H), 3.78(s, 3H), 5.15(s, 2H), 6.93–7.26(m, 4H), 7.36(d, J=7.8Hz, 2H), 7.62(dd, J=4.0, 8.8Hz, 2H), 
               
               
                   
                 9.94(s, 1H) 
               
               
                   
                 IR(KBr)3446, 2933, 2845, 1699, 1521, 1473, 1463, 1381, 1293, 1261, 1238, 1221, 1131, 803cm −1   
               
               
                 I-381 
                 m.p. 118–119° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.74(s, 3H), 2.54(dt, J=5.0, 7.8Hz, 2H), 3.45(s, 3H), 3.78(s, 3H), 4.05(t, J=7.2Hz, 2H), 5.24(t, J=4.4Hz, 1H), 
               
               
                   
                 6.95–7.16(m, 6H), 7.61(dd, J=3.4, 8.8Hz, 2H), 9.95(brs, 1H) 
               
               
                   
                 IR(KBr)3433, 2959, 2930, 2842, 1701, 1602, 1522, 1464, 1379, 1303, 1263, 1222, 1132, 1018cm −1   
               
               
                 I-382 
                 m.p. 93–94° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.74(s, 3H), 1.78(s, 3H), 3.32(s, 3H), 3.71(s, 3H), 4.62(d, J=7.0Hz, 2H), 5.48(t, J=5.8Hz, 1H), 6.91(s, 1H), 7.09–7.35 
               
               
                   
                 (m, 2H), 7.64–7.71(m, 2H) 
               
               
                   
                 IR(KBr)3433, 2976, 2937, 1707, 1604, 1520, 1472, 1376, 1300, 1265, 1226, 1160, 1131, 1060, 839cm −1   
               
               
                 I-383 
                 m.p. 98–99° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.32(s, 3H), 3.31(s, 3H), 3.70(s, 3H), 5.13(s, 2H), 6.88(s, 1H), 7.14–7.39(m, 5H), 7.63–7.70(m, 2H) 
               
               
                   
                 IR(KBr)3433, 2981, 2937, 1704, 1603, 1520, 1470, 1375, 1301, 1266, 1226, 1159, 1061, 839cm −1   
               
               
                 I-384 
                 oil 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.68(s, 3H), 1.74(s, 3H), 2.48–2.56(m, 2H), 3.57(s, 3H), 3.77(s, 3H), 3.98(t, J=4.8Hz, 2H), 5.26(t, J=4.2Hz, 1H), 
               
               
                   
                 6.84(s, 1H), 7.05–7.36(m, 5H), 7.63–7.70(m, 2H) 
               
               
                   
                 IR(KBr)3433, 2979, 2938, 1726, 1603, 1522, 1470, 1376, 1301, 1264, 1226, 1160, 1132, 1080, 1058, 840cm −1   
               
               
                 I-385 
                 m.p. 137–138° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.55(s, 3H), 3.21(s, 3H), 3.57(s, 3H), 3.78(s, 3H), 4.56(d, J=7.0Hz, 2H), 5.52(t, J=7.4Hz, 1H), 
               
               
                   
                 6.84(s, 1H), 7.02(d, J=8.8Hz, 2H), 7.34–7.40(m, 4H), 7.70(d, J=8.8Hz, 2H) 
               
               
                   
                 IR(KBr)3434, 2938, 1607, 1519, 1366, 1244, 1174, 1151, 1072, 871, 796cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 79 
               
               
                   
               
             
            
               
                 I-386 
                 m.p. 169–170° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.48(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 5.08(s, 2H), 6.84(s, 1H), 7.07(d, J=5.8Hz, 2H), 7.19–7.39(m, 4H), 7.70 
               
               
                   
                 (d, J=6.0Hz, 2H) 
               
               
                   
                 IR(KBr)3432, 3016, 2935, 1605, 1519, 1479, 1368, 1357, 1233, 1176, 1151, 1076, 876, 843, 798cm −1   
               
               
                 I-387 
                 m.p. 140–141° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.75(s, 3H), 2.51(dt, J=4.4, 4.6Hz, 2H), 2.55(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 3.97(t, J=4.8Hz, 
               
               
                   
                 2H), 5.26(t, J=4.0Hz, 1H), 6.84(s, 1H), 6.99(d, J=5.8Hz, 2H), 7.34–7.39(m, 4H), 7.70(d, J=5.8Hz, 2H) 
               
               
                   
                 IR(KBr)3445, 2937, 1608, 1519, 1480, 1391, 1361, 1351, 1237, 1177, 1154, 1077, 962, 871, 862, 800cm −1   
               
               
                 I-388 
                 m.p. 124–125° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.73(s, 3H), 1.75(s, 3H), 3.30(s, 3H), 3.65(s, 3H), 4.54(d, J=6.6Hz, 2H), 5.47(t, J=6.4Hz, 1H), 6.40(s, 1H), 6.82–6.94 
               
               
                   
                 (m, 4H), 7.20(d, J=8.6Hz, 2H), 7.44(d, J=8.2Hz, 2H) 
               
               
                   
                 IR(KBr)3411, 2934, 1608, 1523, 1487, 1396, 1231, 1175, 1105, 1072, 996, 898cm −1   
               
               
                 I-389 
                 m.p. 93–94° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.32(s, 3H), 3.32(s, 3H), 3.64(s, 3H), 5.08(s, 2H), 6.40(s, 1H), 6.84(d, J=8.6Hz, 2H), 6.98(d, J=8.6Hz, 2H), 7.19–7.23 
               
               
                   
                 (m, 4H), 7.34–7.46(m, 4H) 
               
               
                   
                 IR(KBr)3398, 2933., 1609, 1523, 1486, 1461, 1398, 1235, 1174, 1119, 1071, 997, 829cm −1   
               
               
                 I-390 
                 oil 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.74(s, 3H), 2.52(dt, J=4.8, 5.0Hz, 2H), 3.24(s, 3H), 3.58(s, 3H), 4.06(t, J=7.2Hz, 2H), 5.24(t, J=4.4Hz, 
               
               
                   
                 1H), 6.80–6.95(m, 4H), 7.22(d, J=8.4Hz, 2H), 7.46(d, J=8.2Hz, 2H) 
               
               
                   
                 IR(KBr)3340, 2934, 1608, 1522, 1486, 1396, 1285, 1230, 1175, 1106, 1072, 996, 828cm −1   
               
               
                 I-391 
                   1 HNMR(CDCl 3  + CD 3 OD) δ 3.05(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 5.16(s, 2H), 5.97(s, 1H), 6.02(s, 1H), 6.47(s, 1H), 6.94(d.d, J=8.4&amp;1.8Hz, 
               
               
                   
                 1H), 7.04(d, J=8.4Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.22–7.52(m, 9H) 
               
               
                   
                 IR(KBr)3548, 3357, 1603, 1589, 1520, 1487, 1460, 1445, 1410, 1329, 1286, 1247, 1153, 1115, 1077, 1010cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 80 
               
               
                   
               
             
            
               
                 I-392 
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 2.77–2.88(broad, 1H), 3.47(s, 3H), 3.64(s, 3H), 3.72(s, 3H), 3.82(s, 3H), 4.32(d.d, J=11.1&amp;0.6Hz, 1H), 
               
               
                   
                 4.45–4.56(broad, 1H), 4.92(s, 1H), 5.16(s, 2H), 6.70(d, J=9.3Hz, 2H), 6.88(s, 1H), 6.92(d, J=9.0Hz, 2H), 7.22(d, J=8.4Hz, 2H), 738(d, J=8.4Hz, 
               
               
                   
                 2H), 7.56(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3476, 1610, 1519, 1476, 1463, 1386, 1265, 1215, 1074, 1041, 1010cm −1   
               
               
                 I-393 
                 foam 
               
               
                   
                   1 HNMR(CD 3 OD) δ 2.34(s, 3H), 3.38(s, 3H), 3.68(s, 3H), 4.00(dd, J=9.9, 8.7Hz, 1H), 4.17(dd, J=9.9, 3.0Hz, 1H), 5.06(dd, J=8.7, 3.0Hz, 
               
               
                   
                 1H), 6.43(s, 1H), 6.78(dd, J=8.7, 1.8, 1H), 6.85(d, J=8.7Hz, 2H), 6.88(d, J=1.8Hz, 1H), 6.91(d, J=8.4Hz, 1H), 7.20(d, J=8.1Hz, 2H), 7.36 
               
               
                   
                 (d, J=8.1Hz, 2H), 7.46(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3367, 1655, 1612, 1586, 1523, 1489, 1459, 1254, 1225, 1115, 1072, 1015, 941, 817cm −1   
               
               
                 I-394 
                 foam 
               
               
                   
                   1 HNMR(CD 3 OD) δ 3.38(s, 3H), 3.67(s, 3H), 4.02(dd, J=10.2, 9.0Hz, 1H), 4.20(dd, J=10.2, 3.3Hz, 1H), 5.11(dd, J=9.0, 3.3Hz, 1H), 6.43 
               
               
                   
                 (s, 1H), 6.78(dd, J=8.4, 2.1, 1H), 6.85(d, J=8.7Hz, 2H), 6.88(d, J=2.1Hz, 1H), 6.91(d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H), 7.30–7.50( 
               
               
                   
                 m, 5H) 
               
               
                   
                 IR(Nujol)3368, 1655, 1612, 1587, 1523, 1489, 1456, 1254, 1225, 1114, 1072, 1014, 941, 825, 764cm −1   
               
               
                 I-395 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.48(s, 3H), 2.82(s, 3H), 3.16(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 6.85(s, 3H), 7.34–7.38(m, 2H), 7.38(d, J=8.1Hz, 
               
               
                   
                 2H), 7.39(d, J=8.7Hz, 2H), 7.46(d, J=1.8Hz, 1H), 7.46(d, J=8.7Hz, 2H), 7.82(d, J=8.1Hz, 2H) 
               
               
                   
                 IR(Nujol)1597, 1514, 1479, 1464, 1177, 1152, 1085, 969, 883, 846, 797, 729cm −1   
               
               
                 I-396 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.85(s, 3H), 3.14(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 6.85(s, 1H), 7.36(m, 2H), 7.39(d, J=8.7Hz, 2H), 7.45, ( 
               
               
                   
                 m, 1H), 7.60(m, 2H), 7.66(d, J=8.7Hz, 2H), 7.74(m, 1H), 7.94(m, 2H) 
               
               
                   
                 IR(Nujol)1612, 1584, 1514, 1479, 1451, 1179, 1152, 1085, 969, 949, 846, 797, 737cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 81 
               
               
                   
               
             
            
               
                 I-397 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.73(s, 3H), 3.21(s, 6H), 3.55(s, 3H), 3.77(s, 3H), 5.20(s, 2H), 6.84(s, 1H), 7.16(brs, 1H), 7.22(d, J=8.1Hz, 1H), 7.33, (d, 
               
               
                   
                 J=2.4Hz, 1H), 7.37(brs, 2H), 7.38(d, J=8.7Hz, 2H), 7.65(brs, 1H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)1608, 1519, 1480, 1464, 1176, 1151, 1080, 972, 876, 846, 798cm −1   
               
               
                 I-398 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.91(s, 3H), 3.19(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 5.26(s, 2H), 5.34(s, 2H), 7.04(brs, 1H), 7.05(s, 2H), 7.12 
               
               
                   
                 (brs, 1H), 7.39(d, J=8.7Hz, 2H), 7.36–7.43(m, 3H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)1608, 1519, 1480, 1463, 1176, 1151, 1079, 972, 876, 799cm −1   
               
               
                 I-399 
                 m.p. 203–205° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.87(s, 3H), 3.35(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.78(s, 3H), 5.39(s, 2H), 7.07(s, 1H), 7.08(d, J=3.9Hz, 1H), 7.16 
               
               
                   
                 (d, J=3.9Hz, 1H), 7.31(dd, J=9.0, 1.8Hz, 1H), 7.33(s, 1H), 7.42(d, J=9.0Hz, 1H), 7.49(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)1609, 1520, 1481, 1455, 1231, 1080, 1013, 984, 947, 878, 832, 798cm −1   
               
               
                 I-400 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.72(s, 3H), 3.14(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 5.14(s, 2H), 6.84(s, 1H), 7.11(d, J=8.7Hz, 1H), 7.34(dd, 
               
               
                   
                 J=2.1, 8.7Hz, 1H), 7.34(d, J=8.4Hz, 2H), 7.37(d, J=8.4Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.54(d, J=8.4Hz, 2H), 7.68(d, J=8.4Hz, 2H) 
               
               
                 I-401 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.83(s, 3H), 3.14(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.26(s, 2H), 6.85(s, 1H), 7.24(d, J=8.4Hz, 1H), 7.38(d, 
               
               
                   
                 J=8.4Hz, 1H), 7.41(dd, J=2.1, 8.4Hz, 1H), 7.44(d, J=2.1Hz, 1H), 7.67(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1609, 1523, 1509, 1481, 1367, 1402, 1178, 1152, 1080, 973, 943, 876, 798cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 82 
               
               
                   
               
             
            
               
                 I-402 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.68(s, 3H), 3.14(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.66(s, 2H), 3.71(s, 3H), 3.78(s, 3H), 5.18(s, 2H), 6.84(s, 1H), 7.14( 
               
               
                   
                 d, J=8.4Hz, 1H), 7.32(d, J=8.7Hz, 1H), 7.35(dd, J=2.1, 8.7Hz, 1H), 7.37(d, J=8.4Hz, 2H), 7.39(d, J=2.1Hz, 1H), 7.42(d, J=8.4Hz, 2H), 7.67 
               
               
                   
                 (d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1736, 1610, 1519, 1481, 1365, 1177, 1151, 1079, 876, 817, 798cm −1   
               
               
                 I-403 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.70(s, 3H), 3.16(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.24(s, 2H), 6.84(s, 1H), 7.18(d, J=8.4Hz, 1H), 7.36(dd, 
               
               
                   
                 J=1.5, 8.4Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.41(d, J=1.5Hz, 1H), 7.46(m, 2H), 7.54(d, J=8.1Hz, 2H), 7.62(m, 3H), 7.64(d, J=8.1Hz, 2H), 
               
               
                   
                 7.68(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1609, 1519, 1481, 1365, 1177, 1151, 1079, 1014, 876, 818, 797cm −1   
               
               
                 I-404 
                 m.p. 128–130° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.75(s, 3H), 2.92(s, 3H), 3.18(t, J=6.9Hz, 2H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.34(t, J=6.9Hz, 2H), 6.81(s, 1H), 
               
               
                   
                 7.08(d, J=8.4Hz, 1H), 7.29(m, 2H), 7.32(br.s, 3H), 7.35(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.39(d, J=2.1Hz, 1H), 7.67(d, J=8.4Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr)1609, 1520, 1481, 1364, 1177, 1151, 1080, 872, 815, 797cm −1   
               
               
                 I-405 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.71(d, J=6.3Hz, 3H), 2.45(br.s, 3H), 3.20(s, 3H), 3.28(s, 3H), 3.53(s, 3H), 3.75(s, 3H), 5.43(q, J=6.3Hz, 1H), 6.81(s, 
               
               
                   
                 1H), 6.90(d, J=8.4Hz, 1H), 7.16(dd, J=2.1, 8.4Hz, 1H), 7.30(m, 1H), 7.36(d, J=2.1Hz, 1H), 7.37(d, J=8.4Hz, 2H), 7.35–7.41(m, 4H), 7.66 
               
               
                   
                 (d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1609, 1518, 1480, 1365, 1177, 1151, 1078, 874, 818, 798cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 83 
               
               
                   
               
             
            
               
                 I-406 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.02(t, J=9.0Hz, 3H), 2.04(dq, J=6.3, 9.0Hz, 2H), 2.39(br.s, 3H), 3.20(s, 3H), 3.30(s, 3H), 3.53(s, 3H), 3.75(s, 3H), 5.18 
               
               
                   
                 (t, J=6.3Hz, 1H), 6.80(s, 1H), 6.88(d, J=8.4Hz, 1H), 6.92(m, 1H), 7.14(dd, J=2.4, 8.4Hz, 1H), 7.25–7.40(m, 7H), 7.66(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1609, 1518, 1480, 1365, 1177, 1151, 1079, 874, 819, 797cm −1   
               
               
                 I-407 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.46(s, 3H), 3.07(s, 3H), 3.20(s, 3H), 3.54(s, 3H), 3.76(s, 3H), 6.33(s, 1H), 6.82(s, 1H), 6.99(d, J=9.0Hz, 1H), 7.19(dd, 
               
               
                   
                 J=2.1, 9.0Hz, 1H), 7.26–7.40(m, 9H), 7.43–7.47(m, 4H), 7.66(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1607, 1518, 1481, 1364, 1177, 1151, 1081, 873, 822, 798cm −1   
               
               
                 I-408 
                 m.p. 179–180 ° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(d, J=6.3Hz, 3H), 2..34(br.s, 3H), 2.45(s, 3H), 3.20(s, 3H), 3.27(s, 3H), 3.54(s, 3H), 3.75(s, 3H), 5.40(q, J=6.3Hz, 
               
               
                   
                 1H), 6.81(s, 1H), 6.92(d, J=8.7Hz, 1H), 7.15(d, J=8.7Hz, 2H), 7.16(dd, J=2.1, 8.4Hz, 1H), 7.27(d, J=8.7Hz, 1H), 7.35(d, J=2.1Hz, 1H), 
               
               
                   
                 7.37(d, J=8.4Hz, 2H), 7.66(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1609, 1518, 1480, 1365, 1177, 1151, 1078, 874, 819, 797cm −1   
               
               
                 I-409 
                 m.p. 243–244° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.30(s, 3H), 3.64(s, 3H), 5.19(s, 2H), 6.39(s, 1H), 6.64(dd, J=1.8, 8.4Hz, 1H), 6.77(d, J=1.8Hz, 1H), 6.83(d, J=8.4Hz, 
               
               
                   
                 2H), 6.97(d, J=8.4Hz, 1H), 7.37(t, J=7.5Hz, 1H), 7.44(d, J=8.4Hz, 2H), 7.48(t, J=8.4Hz, 2H), 7.60(d, J=8.4Hz, 2H), 7.67–7.73(m, 
               
               
                   
                 5H) 
               
               
                   
                 IR(KBr)3421, 1610, 1523, 1488, 1463, 1403, 1176, 1115, 1072, 821cm −1   
               
               
                 I-410 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.18(t, J=6.9Hz, 2H), 3.45(s, 3H), 3.73(s, 3H), 4.31(t, J=6.9Hz, 2H), 6.44(s, 1H), 6.91(d, J=8.4Hz, 2H), 6.94(br.s, 2H), 
               
               
                   
                 7.03(br.s, 1H), 7.23–7.37(m, 5H), 7.53(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3434, 1612, 1587, 1523, 1489, 1455, 1403, 1250, 1113, 1070, 1011, 825, 815cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 84 
               
               
                   
               
             
            
               
                 I-411 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.70(d, J=6.0Hz, 3H), 3.44(s, 3H), 3.72(s, 3H), 5.36(q, J=6.0Hz, 1H), 6.42(s, 1H), 6.78(d, J=8.1Hz, 1H), 6.81(dd, J=1.5, 
               
               
                   
                 8.7Hz, 1H), 6.91(d, J=8.4Hz, 2H), 7.06(d, J=1.5Hz, 1H), 7.26–7.42(m, 4H), 7.51(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3472, 1612, 1587, 1523, 1488, 1454, 1403, 1248, 1113, 1070, 1011, 825,cm −1   
               
               
                 I-412 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.03(t, J=7.2Hz, 3H), 1.94(m, 1H), 2.06(m, 1H), 3.43(s, 3H), 3.72(s, 3H), 5.08(dd, J=7.2, 5.4Hz, 1H), 6.43(s, 1H), 6.73(d, 
               
               
                   
                 J=8.4Hz, 1H), 6.78(dd, J=1.8, 8.4Hz, 1H), 6.90(d, J=8.4Hz, 2H), 7.05(d, J=1.8Hz, 1H), 7.25–7.38(m, 5H), 7.51(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3434, 1612, 1522, 1488, 1454, 1403, 1247, 1113, 1070, 1011, 826, 811cm −1   
               
               
                 I-413 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.44(s, 3H), 3.73(s, 3H), 6.25(s, 1H), 6.43(s, 1H), 7.26(m, 2H), 6.90(d, J=8.4Hz, 2H), 7.08(d, J=2.1Hz, 1H), 7.29–7.43 
               
               
                   
                 (m, 10H), 7.51(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3432, 1611, 1523, 1489, 1454, 1402, 1226, 1110, 1069, 1011, 825cm −1   
               
               
                 I-414 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(d, J=6.3Hz, 3H), 2..35(s, 3H), 3.44(s, 3H), 3.72(s, 3H), 5.33(q, J=6.3Hz, 1H), 6.42(s, 1H), 6.80(br.s, 2H), 6.90( 
               
               
                   
                 d, J=8.4Hz, 2H), 7.05(br.s, 1H), 7.18(d, J=7.8Hz, 2H), 7.29(d, J=7.8Hz, 2H), 7.51(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3433, 1612, 1522, 1488, 1459, 1403, 1248, 1113, 1069, 1011, 817cm −1   
               
               
                 I-415 
                 m.p. 164–167° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.79(s, 3H), 3.80(s, 3H), 4.81(brs, 1H), 5.29(s, 2H), 6.88–6.94(m, 4H), 7.16(d, J=8.7Hz, 1H), 7.32–7.52(m, 7H), 7.73 
               
               
                   
                 (dd, J=2.1, 8.7Hz, 1H), 8.10(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr)3513, 2930, 1618, 1529, 1497, 1448, 1387, 1354, 1296, 1257, 1211, 1168, 1091, 1064, 1024cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 85 
               
               
                   
               
             
            
               
                 I-416 
                 m.p. 155–159° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.20(s, 3H), 3.39(s, 3H), 3.82(s, 3H), 3.83(s, 3H)6.95(s, 1H), 6.96(s, 1H), 7.34–7.38(m, 2H), 7.58–7.64(m, 3H), 7.87( 
               
               
                   
                 dd, J=2.1, 8.4Hz, 1H), 8.26(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr)3433, 2944, 1539, 1519, 1487, 1358, 1216, 1176, 1150, 1086, 1057, 1031cm −1   
               
               
                 I-417 
                 m.p. 124–126° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.19(s, 3H), 3.80(s, 6H), 5.30(s, 2H), 6.93(s, 1H), 6.94(s, 1H), 7.18(d, J=9.0Hz, 1H), 7.32–7.52(m, 7H), 7.59–7.64(m, 
               
               
                   
                 2H), 7.73(dd, J=2.1, 9.0Hz, 1H), 8.10(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr)3433, 2937, 1619, 1531, 1491, 1465, 1450, 1358, 1290, 1256, 1211, 1176, 1150, 1088, 1062, 1033cm −1   
               
               
                 I-418 
                 m.p. 151–153° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.18(s, 3H), 3.781(s, 3H), 3.784(s, 3H), 5.14(s, 2H), 6.90–7.00(m, 5H), 7.31–7.50(m, 7H), 7.60–7.65(m, 2H) 
               
               
                   
                 IR(KBr)3480, 3383, 2930, 1610, 1523, 1489, 1467, 1383, 1358, 1330, 1211, 1175, 1147, 1024cm −1   
               
               
                 I-419 
                 m.p. 198–200° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.77(s, 6H), 5.13(s, 2H), 6.86–7.00(m, 7H)7.34–7.50(m, 7H) 
               
               
                   
                 IR(KBr)3403, 3327, 1611, 1592, 1525, 1492, 1462, 1444, 1384, 1318, 1273, 1243, 1209, 1178, 1149, 1110, 1058, 1037, 1006cm −1   
               
               
                 I-420 
                 m.p. 168–171° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.99(s, 3H), 3.19(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.16(s, 2H), 6.83(brs, 1H), 6.92(s, 1H), 6.96(s, 1H), 7.06(d, J=8.7Hz, 1H), 
               
               
                   
                 7.32–7.46(m, 8H), 7.60–7.64(m, 2H), 7.81(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr)3403, 3327, 1611, 1592, 1525, 1492, 1462, 1444, 1384, 1318, 1273, 1243, 1209, 1178, 1149, 1110, 1058, 1037, 1006cm −1   
               
               
                 I-421 
                 m.p. 168–171° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.19(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.23(s, 2H), 6.93(s, 1H), 6.97(s, 1H), 7.07(d, J=8.7Hz, 1H), 7.33–7.45(m, 8H),  
               
               
                   
                 7.61–7.65(m, 2H), 8.58(d, J=2.4Hz, 1H), 8.66(brs, 1H) 
               
               
                   
                 IR(KBr)3401, 1723, 1613, 1595, 1549, 1518, 1486, 1385, 1365, 1330, 1299, 1256, 1212, 1151, 1119, 1060, 1037, 1017cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 86 
               
               
                   
               
             
            
               
                 I-422 
                 m.p. 159–160° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.74, (s, 3H), 2.55(q, J=7.2Hz, 2H), 2.73(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.06(t, J=7.2Hz, 2H), 
               
               
                   
                 5.24(t, J=7.2Hz, 1H), 6.85(s, 1H), 7.07(d, J=8.6Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.55(dd, J=8.6, 2.1Hz, 1H), 7.63(d, J=2.1Hz, 1H), 7.68 
               
               
                   
                 (d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)1515, 1481, 1359, 1325, 1175, 1140, 1079, 870, 799cm −1   
               
               
                 I-423 
                 m.p. 180–182° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81, (s, 3H), 2.71(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 4.06(d, J=6.3Hz, 2H), 5.50(t, J=6.3Hz, 1H), 
               
               
                   
                 6.85(s, 1H), 7.09(d, J=8.7Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.55(dd, J=8.7, 2.0Hz, 1H), 7.64(d, J=2.0Hz, 1H), 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)1514, 1479, 1360, 1241, 1174, 1132, 1078, 866, 800cm −1   
               
               
                 I-424 
                 m.p. 176–178° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.64(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.26(s, 2H), 6.85(s, 1H), 7.14(d, J=8.6Hz, 1H), 7.33–7.48(m, 7H), 7.54 
               
               
                   
                 (dd, J=8.6, 2.1Hz, 1H), 7.66–7.70(m, 3H) 
               
               
                   
                 IR(KBr)1517, 1482, 1367, 1327, 1178, 1150, 1135, 1081, 878, 797cm −1   
               
               
                 I-425 
                 m.p. 199–200° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 2.63(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.21(s, 2H), 6.84(s, 1H), 7. 13(d, J=8.7Hz, 1H), 7.20(d, 
               
               
                   
                 J=8.0Hz, 2H), 7.34(d, J=8.0Hz, 2H), 7.38(d, J=9.0Hz, 2H), 7.53(dd, J=8.7, 1.8Hz, 1H), 7.66(d, J=1.8Hz, 1H), 7.68(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)1517, 1481, 1366, 1326, 1255, 1177, 1151, 1082, 871, 798cm −1   
               
               
                 I-426 
                 amorphous 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.73(s, 3H), 2.54(q, J=7.2Hz, 2H), 3.44(s, 3H), 3.75(s, 3H), 4.05(t, J=7.2Hz, 2H), 5.07(s, 1H), 5.24(t, J=7.2Hz, 
               
               
                   
                 1H), 6.02(s, 1H), 6.45(s, 1H), 6.92(d, J=8.6Hz, 2H), 7.41(d, J=8.6Hz, 1H), 7.53(d, J=8.6Hz, 2H), 7.59(dd, J=8.6, 2.0Hz, 1H), 7.63 
               
               
                   
                 (d, J=2.0Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )3595, 3506, 1614, 1523, 1489, 1326, 1281, 1258, 1122, 1079, 1057cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 87 
               
               
                   
               
             
            
               
                 I-427 
                 m.p. 180–182° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.75(s, 3H), 1.80(s, 3H), 3.44(s, 3H), 3.76(s, 3H), 4.66(d, J=6.6Hz, 2H), 4.87(s, 1H), 5.52(t, J=6.6Hz, 1H), 6.02(s, 1H), 
               
               
                   
                 6.46(s, 1H), 6.93(d, J=8.9Hz, 2H), 7.06(d, J=8.4Hz, 1H), 7.53(d, J=8.9Hz, 2H), 7.59(dd, J=8.4, 2.1Hz, 1H), 7.71(d, J=2.1Hz, 1H), 
               
               
                   
                 IR(KBr)3406, 1615, 1522, 1488, 1399, 1324, 1280, 1256, 1138, 1116, 1076, 1054, 996, 835, 826cm −1   
               
               
                 I-428 
                 m.p. 133–135° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.44(s, 3H), 3.75(s, 3H), 4.87(s, 1H), 5.23(s, 2H), 6.03(s, 1H), 6.46(s, 1H), 6.93(d, J=8.6Hz, 2H), 7.11(d, J=8.4Hz, 1H), 
               
               
                   
                 7.32–7.49(m, 5H), 7.53(d, J=8.6Hz, 2H), 7.60(dd, J=8.4, 2.1Hz, 1H), 7.75(d, J=2.1Hz, 1H), 
               
               
                   
                 IR(KBr)3397, 1612, 1523, 1489, 1400, 1321, 1257, 1132, 1084, 1056, 1002, 832cm −1   
               
               
                 I-429 
                 m.p. 174–176° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 3.44(s, 3H), 3.75(s, 3H), 4.88(s, 1H), 5.18(s, 2H), 6.02(s, 1H), 6.45(s, 1H), 6.93(d, J=8.6Hz, 2H), 7.11(d, 
               
               
                   
                 J=8.4Hz, 1H), 7.21(d, J=8.1Hz, 2H), 7.36(d, J=8.1Hz, 2H), 7.53(d, J=8.6Hz, 2H), 7.59(dd, J=8.4, 2.1Hz, 1H), 7.74(d, J=2.1Hz, 1H), 
               
               
                   
                 IR(KBr)3481, 3376, 1616, 1520, 1491, 1327, 1260, 1119, 1081, 1004, 827cm −1   
               
               
                 I-430 
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 2.54(s, 3H), 2.68(s, 3H), 3.12(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 5.14(s, 2H), 6.85(s, 1H), 7.12–7.24(m, 3H), 
               
               
                   
                 7.30–7.44(m, 6H), 7.53–7.59(m, 2H) 
               
               
                   
                 IR(CHCl 3 )1608, 1517, 1476, 1367, 1117, 1080, 1013, 970, 876cm −1   
               
               
                 I-431 
                 m.p. 164–168° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 2.54(s, 3H), 3.47(s, 3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.53(m, 1H), 5.69(s, 1H), 5.89(s, 
               
               
                   
                 1H), 6.46(s, 1H), 6.92–7.08(m, 3H), 7.30–7.38(m, 2H), 7.55–7.62(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3518, 2968, 1584, 1516, 1483, 1460, 1414, 1388, 1310, 1289, 1243, 1114, 1069, 1011, 936, 818cm −1   
               
               
                 I-432 
                 m.p. 179–181° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.39(s, 3H), 2.54(s, 3H), 3.46(s, 3H), 3.74(s, 3H), 5.10(s, 2H), 5.67(s, 1H), 5.89(s, 1H), 6.46(s, 1H), 6.81(dd, J=2.1, 8.4Hz, 
               
               
                   
                 1H), 7.03(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.20–7.26(m, 2H), 7.31–7.37(m, 4H), 7.55–7.61(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3524, 2930, 1585, 1517, 1483, 1460, 1414, 1389, 1310, 1289, 1245, 1114, 1090, 1070, 1009, 937, 818cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 88 
               
               
                   
               
             
            
               
                 I-433 
                 m.p. 111–112° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(d, J=0.6Hz, 3H), 1.81(d, J=0.9Hz, 3H), 2.69(s, 3H), 3.52(s, 3H), 3.78(s, 3H), 4.63(t, J=6.6Hz, 2H), 5.53(m, 1H), 
               
               
                   
                 6.84(s, 1H), 7.02–7.25(m, 5H), 7.56–7.65(m, 2H) 
               
               
                   
                 IR(CHCl 3 )2932, 1607, 1520, 1481, 1368, 1266, 1080, 1012, 961, 907, 836, 812cm −1   
               
               
                 I-434 
                 m.p. 97–101° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.75(d, J=0.9Hz, 3H), 2.48–2.58(m, 5H), 3.46(s, 3H), 3.47(s, 3H), 4.06(t, J=6.9Hz, 2H), 5.22(m, 1H), 5.67 
               
               
                   
                 (s, 1H), 5.88(s, 1H), 6.46(s, 1H), 6.92–6.97(m, 2H), 7.05(m, 1H), 7.30–7.38(m, 2H), 7.55–7.62(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3518, 2928, 1584, 1517, 1483, 1414, 1388, 1290, 1246, 1114, 1090, 1070, 1011, 937, 907, 818cm −1   
               
               
                 I-435 
                 m.p. 127–129° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.74(d, J=1.2Hz, 3H), 2.50–2.60(m, 2H), 2.71(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 4.04(t, J=7.2Hz, 2H), 5.23 
               
               
                   
                 (m, 1H), 6.83(s, 1H), 7.00–7.21(m, 5H), 7.57–7.64(m, 2H) 
               
               
                   
                 IR(CHCl 3 )2930, 1607, 1520, 1481, 1368, 1266, 1080, 1012, 960, 836, 812cm −1   
               
               
                 I-436 
                 m.p. 159–161° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.36(s, 3H), 2.57(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 6.83(s, 1H), 7.05–7.24(m, 7H), 7.31–7.37(m, 2H), 7.56–7.65 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(CHCl 3 )1520, 1481, 1368, 1267, 1131, 1080, 1012, 960, 836cm −1   
               
               
                 I-437 
                 m.p. 120–124° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(d, J=0.6Hz, 3H), 1.81(d, J=0.6Hz, 3H), 3.43(s, 3H), 3.67(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.56(m, 1H), 5.96(s, 1H), 
               
               
                   
                 6.44(s, 1H), 7.00–7.24(m, 5H), 7.57–7.66(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3522, 2930, 1586, 1518, 1484, 1415, 1390, 1311, 1290, 1248, 1115, 1090, 1071, 1012, 938, 818cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 89 
               
               
                   
               
             
            
               
                 I-438 
                 m.p. 140.5–141.5° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 3.43(s, 3H), 3.75(s, 3H), 5.14(s, 2H), 5.97(s, 1H), 6.44(s, 1H), 7.04–7.28(m, 7H), 7.36(d, J=8.1Hz, 1H),  
               
               
                   
                 7.57–7.65(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3496, 2932, 1613, 1520, 1488, 1460, 1391, 1313, 1267, 1113, 1069, 1010, 934, 825cm −1   
               
               
                 I-439 
                 m.p. 76.5–77.5° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.49–2.60(m, 2H), 3.43(s, 3H), 3.75(s, 3H), 4.05(t, J=7.2Hz, 2H), 5.23(m, 1H), 5.96 
               
               
                   
                 (s, 1H), 6.44(s, 1H), 6.99–7.28(m, 5H), 7.57–7.66(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3498, 2930, 1613, 1521, 1489, 1391, 1310, 1267, 1113, 1070, 1011, 934, 825cm −1   
               
               
                 I-440 
                 m.p. 174–176° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.80(s, 3H), 3.46(s, 3H), 3.76(s, 3H), 5.16(s, 2H), 5.71(s, 1H), 5.88(s, 1H), 6.47(s, 1H), 6.95(dd, J=1.8, 8.4Hz, 1H), 7.04(d, 
               
               
                   
                 J=8.4Hz, 1H), 7.08(d, J=1.8Hz, 1H), 7.34–7.49(m, 5H), 7.72–7.85(m, 4H) 
               
               
                   
                 IR(CHCl 3 )3518, 1587, 1516, 1483, 1459, 1415, 1387, 1290, 1114, 1070, 1041, 1011, 936, 821cm −1   
               
               
                 I-441 
                 m.p. 199–202° C. 
               
               
                   
                   1 HNMR(d6-DMSO) δ 3.28(s, 3H), 3.34(s, 3H), 3.67(s, 3H), 5.14(s, 2H), 6.52(s, 1H), 6.66(dd, J=2.1, 8.4Hz, 1H), 6.79(d, J=2.1Hz, 1H), 
               
               
                   
                 6.97(d, J=8.4Hz, 1H), 7.30–7.56(m, 5H), 7.86–7.93(m, 2H), 7.98–8.04(m, 2H), 8.65–9.02(brs, 2H) 
               
               
                   
                 IR(KBr)3487, 3413, 3004, 1597, 1518, 1500, 1482, 1456, 1360, 1310, 1281, 1231, 1146, 1118, 1090, 1068, 1016, 1004, 961cm −1   
               
               
                 I-442 
                 m.p. 80–84° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.15(t, J=7.2Hz, 3H), 3.60(q, J=7.2Hz, 2H), 3.75(s, 3H), 5.03(s, 1H), 5.15(s, 2H), 5.69(s, 1H), 5.98(s, 1H), 6.45(s, 1H), 
               
               
                   
                 6.88–6.94(m, 2H), 6.96(dd, J=2.1, 8.1Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.10(d, J=2.1Hz, 1H), 7.34–7.49(m, 5H), 7.51–7.59(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3528, 1612, 1521, 1488, 1454, 1412, 1383, 1286, 1246, 1113, 1069, 1023, 886, 825cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 90 
               
               
                   
               
             
            
               
                 I-443 
                 m.p. 168–169° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.14(t, J=6.9Hz, 3H), 2.66(s, 3H), 3.13(s, 3H), 3.20(s, 3H), 3.72(q, J=6.9Hz, 2H), 3.78(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 
               
               
                   
                 7.15(d, J=8.4Hz, 1H), 7.31–7.49(m, 9H), 7.66–7.73(m, 5H) 
               
               
                   
                 IR(CHCl 3 )1517, 1479, 1369, 1148, 1117, 1082, 969, 873cm −1   
               
               
                 I-444 
                 m.p. 192–194° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.13(s, 3H), 3.44(s, 3H), 3.63(s, 3H), 3.76(s, 3H), 5.14(br, 1H), 5.19(s, 2H), 6.81–6.84(m, 2H), 6.94(s, 1H), 7.14(d, J=8.4Hz, 
               
               
                   
                 1H), 7.22–7.25(m, 2H), 7.37–7.50(m, 5H)7.57(dd, J=8.7, 2.1Hz, 1H), 7.67(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )3595, 3441, 1730, 1613, 1522, 1472, 1371, 1291, 1258, 1172, 1164, 1003, 972, 961, 904, 838cm −1   
               
               
                 I-445 
                 m.p. 179–180° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.31(s, 3H), 3.24(s, 3H), 3.45(s, 3H), 3.58(s, 3H), 3.76(s, 3H), 4.64(d, J=6.9Hz, 2H), 6.95(s, 
               
               
                   
                 1H), 7.06–7.13(m, 3H), 7.35–7.38(m, 2H), 7.57(dd, J=8.4, 2.4Hz, 1H), 7.64(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )2938, 1732, 1614, 1599, 1518, 1470, 1445, 1370, 1345, 1290, 1228, 1200, 1169, 1116, 1081, 1003, 973, 905, 846, 829cm −1   
               
               
                 I-446 
                 m.p. 137–138° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.13(s, 3H), 3.45(s, 3H), 3.59(s, 3H), 3.77(s, 3H), 3.88(s, 3H), 4.23(s, 2H), 5.19(s, 2H), 6.96(s, 1H), 7.15(d, J=8.7Hz, 
               
               
                   
                 1H), 7.35–7.50(m, 9H), 7.60(dd, J=8.7, 2.4Hz, 1H), 7.67(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )2954, 1750, 1734, 1614, 1516, 1471, 1387, 1372, 1345, 1291, 1258, 1173, 1147, 1118, 1081, 1064, 1004, 877cm −1   
               
               
                 I-447 
                 m.p. 184–185° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.44(s, 3H), 3.60(s, 3H), 3.74(s, 3H), 4.70(br, 2H), 5.17(s, 2H), 6.95–7.02(m, 4H), 7.17(dd, J=8.4, 2.1Hz, 1H), 7.25(s, 
               
               
                   
                 1H), 7.31–7.34(d, J=8.7Hz, 2H), 7.38–7.47(m, 5H) 
               
               
                   
                 IR(CHCl 3 )3541, 2937, 1776, 1733, 1608, 1519, 1474, 1442, 1344, 1291, 1157, 1130, 1085, 1063, 1002, 900, 862, 1835cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 91 
               
               
                   
               
             
            
               
                 I-448 
                 m.p. 176–178° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.12(s, 3H), 3.44(s, 3H), 3.60(s, 3H), 3.76(s, 3H), 3.83(s, 3H), 4.66(s, 2H), 5.19(s, 2H), 6.91–6.96(m, 3H), 7.14(d, J=8.4Hz, 
               
               
                   
                 1H), 7.28–7.49(m, 7H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.67(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )2953, 2939, 1758, 1732, 1610, 1519, 1471, 1444, 1371, 1345, 1291, 1177, 1117, 1085, 1064, 1002, 973, 961, 904, 837cm −1   
               
               
                 I-449 
                 m.p. 124–126° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.31(s, 3H), 2.53–2.60(m, 2H), 3.23(s, 3H), 3.44(s, 3H), 3.58(s, 3H), 3.76(s, 3H), 4.09 
               
               
                   
                 (t, J=6.6Hz, 2H), 5.22(m, 1H), 6.95(s, 1H), 7.07(d, J=8.4Hz, 1H), 7.10–7.13(m, 2H), 7.34–7.37(m, 2H), 7.57(dd, J=9.0, 2.4Hz, 1H), 7.6 
               
               
                   
                 4(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )2938, 1732, 1614, 1518, 1469, 1445, 1370, 1291, 1257, 1170, 1167, 1081, 1004, 973, 961, 906, 846cm −1   
               
               
                 I-450 
                 m.p. 160–161° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.74(d, J=0.9, 3H), 2.53–2.60(m, 2H), 3.23(s, 3H), 3.44(s, 3H), 3.62(s, 3H), 3.76(s, 3H), 4.08(d, J=6.6Hz, 
               
               
                   
                 2H), 4.91(br, 1H), 5.20–5.25(m, 1H), 6.83–6.86(m, 2H), 6.94(s, 1H), 7.06(d, J=8.7Hz, 2H), 7.23–7.26(m, 2H), 7.57(dd, J=8.7, 2.4Hz, 1H), 
               
               
                   
                 7.64(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )3595, 3448, 2937, 1730, 1613, 1522, 1469, 1445, 1370, 1345, 1292, 1260, 1172, 1117, 1081, 1064, 1003, 973, 864, 837cm −1   
               
               
                 I-451 
                 m.p. 182–184° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.70(d, J=0.6Hz, 3H), 1.81(d, J=0.9Hz, 3H), 3.24(s, 3H), 3.45(s, 3H), 3.63(s, 3H), 3.75(s, 3H), 4.64(d, J=6.6Hz, 2H), 
               
               
                   
                 5.48–5.54(m, 1H), 5.76(br, 1H), 6.78–6.82(m,2H), 6.95(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.19–7.24(m, 2H), 7.56(dd, J=8.7, 2.4Hz, 1H), 7.6 
               
               
                   
                 4(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )3595, 3445, 2939, 1730, 1613, 1522, 1471, 1445, 1369, 1345, 1291, 1257, 1172, 1116, 1081, 1064, 1002, 973, 904, 838cm −1   
               
               
                 I-452 
                 m.p. 250–253° C.(dec.) 
               
               
                   
                   1 HNMR(CD 3 OD) δ 3.41(s, 3H), 3.71(s, 3H), 4.58(s, 2H), 5.21(s, 2H), 6.29–6.95(m, 3H), 7.02–7.03(m, 2H), 7.17(s, 1H), 7.26–7.41(m, 5H), 
               
               
                   
                 7.49–7.52(m, 2H) 
               
               
                   
                 IR(KBr)3424, 2933, 2553, 1709, 1608, 1519, 1467, 1383, 1333, 1291, 1229, 1129, 1084, 1060, 1001, 915, 861, 841, 727, 697cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 92 
               
               
                   
               
             
            
               
                 I-453 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.75(d, J=1.2Hz, 3H), 2.51–2.58(m, 2H), 3.43(s, 3H), 3.62(s, 3H), 3.75(s, 3H), 4.08(t, J=6.9Hz, 2H), 4.85(br,  
               
               
                   
                 1H), 5.23(m, 1H), 5.71(br, 1H), 6.82–6.85(m, 2H), 6.90–6.94(m, 2H), 7.16(dd, J=8.4, 2.1Hz, 1H), 7.23–7.26(m, 3H) 
               
               
                   
                 IR(CHCl 3 )3596, 3541, 2936, 1730, 1612, 1590, 1522, 1470, 1395, 1345, 1290, 1258, 1173, 1130, 1081, 1063, 1004, 861, 836cm −1   
               
               
                 I-454 
                 m.p. 166–167° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.51–5.55(m, 1H), 5.75(br, 1H), 6.77– 
               
               
                   
                 6.80(m, 2H), 6.93–6.96(m, 2H), 7.17(dd, J=8.1, 2.1Hz, 1H), 7.23–7.28(m, 3H) 
               
               
                   
                 IR(KBr)3447, 2937, 1590, 1559, 1522, 1473, 1382, 1338, 1295, 1259, 1131, 1080, 1059, 999, 918, 862, 837, 815, 791, 754cm −1   
               
               
                 I-455 
                 m.p. 168–170° C. 
               
               
                   
                   1 HNMR(CD 3 OD) δ 1.68(s, 3H), 1.74(s, 3H), 2.50–2.58(m, 2H), 3.41(s, 3H), 3.73(s, 3H), 4.05(t, J=6.9Hz, 2H), 5.29(m, 1H), 6.76–6.79 
               
               
                   
                 (m, 2H), 6.98–7.17(m, 6H) 
               
               
                   
                 IR(KBr)3411, 2964, 2936, 1685, 1613, 1590, 1523, 1472, 1379, 1293, 1259, 1229, 1131, 1082, 1061, 1000, 962, 861, 838, 814, 791, 754, 
               
               
                   
                 529cm −1   
               
               
                 I-456 
                 m.p. 153–155° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.14(s, 3H), 3.50(s, 3H), 3.77(s, 3H), 5.20(s, 2H), 7.10–7.28(m, 6H), 7.38–7.50(m, 5H), 7.56(dd, J=8.4, 2.1Hz, 1H), 
               
               
                   
                 7.65(d, J=2.1Hz, 1H), 9.98(s, 1H) 
               
               
                   
                 IR(CHCl 3 )2938, 2843, 1697, 1604, 1590, 1517, 1469, 1372, 1331, 1293, 1254, 1172, 1159, 1123, 1093, 1005, 963, 818cm −1   
               
               
                 I-457 
                 m.p. 143–145° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.83(s, 3H), 3.44(s, 3H), 3.63(s, 3H), 3.75(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.53(m, 1H), 5.72(br, 1H), 6.82– 
               
               
                   
                 6.85(m, 2H), 6.92–6.95(m, 2H), 7.16(dd, J=8.4, 2.4Hz, 1H), 7.23–7.26(m, 3H) 
               
               
                   
                 IR(CHCl 3 )3595, 3537, 2938, 1729, 1612, 1591, 1522, 1473, 1395, 1344, 1290, 1258, 1173, 1129, 1081, 1063, 1003, 900, 862, 836cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 93 
               
               
                   
               
             
            
               
                 I-458 
                 powder 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 3.08(s, 3H), 3.11(s, 3H), 3.21(s, 3H), 3.51(s, 3H), 3.52(s, 3H), 5.26(s, 2H), 7.19–7.23(m, 2H), 7.36–7.43 
               
               
                   
                 (m, 4H), 7.45–7.50(m, 2H), 7.82(d, J=2.1Hz, 1H), 7.98(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )3033, 2942, 1543, 1377, 1220, 1181, 1153, 1034cm −1   
               
               
                 I-459 
                 m.p. 182–187° C.(dec.) 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.36(s, 3H), 2.73(s, 3H), 3.16(s, 3H), 3.22(s, 3H), 3.43(s, 3H), 3.47(s, 3H), 5.08(s, 2H), 6.85(brs, 1H), 6.92(brs, 1H), 7.17– 
               
               
                   
                 7.21(m, 2H), 7.32–7.38(m, 2H), 7.39–7.44(m, 2H), 7.50–7.55(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3030, 2939, 1618, 1599, 1513, 1468, 1416, 1372, 1178, 1150, 1031cm −1   
               
               
                 I-460 
                 powder 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 2.83(s, 3H), 3.05(s, 3H), 3.22(s, 3H), 3.56(s, 3H), 3.80(s, 3H), 3.91(s, 3H)5.13(s, 2H), 6.86(s, 1H), 7.20–7.24 
               
               
                   
                 (m, 2H), 7.37–7.46(m, 4H), 7.65–7.70(m, 3H), 7.89(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )3032, 2940, 1728, 1473, 1373, 1232, 1179, 1150, 1085cm −1   
               
               
                 I-461 
                 amorphous 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.78(s, 6H), 5.16(s, 2H), 5.31(d, J=3.6Hz, 1H), 5.72(s, 1H), 6.91(s, 1H), 6.94(s, 1H), 6.99(d, J=8.2Hz, 1H), 7.04(t, J=8.6Hz, 
               
               
                   
                 1H), 7.08(dd, J=8.2, 2.1Hz, 1H), 7.22(d, J=2.1Hz, 1H), 7.25(ddd, J=8.6, 1.8, 0.9Hz, 1H), 7.34–7.46(m, 6H) 
               
               
                   
                 IR(CHCl 3 )3577, 3548, 1526, 1495, 1280, 1635cm −1   
               
               
                 I-462 
                 m.p. 153–155° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.12(s, 3H), 3.26(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.18(s, 2H), 6.91(s, 1H), 6.94(s, 1H), 7.12(d, J=8.4Hz, 1H), 7.36–7.50 
               
               
                   
                 (m, 8H), 7.59(d, J=1.8Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )1494, 1367, 1212, 1180, 1116, 872, 808cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 94 
               
               
                   
               
             
            
               
                 I-463 
                 m.p. 125–127° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 3.23(s, 3H), 3.27(s, 3H), 3.80(s, 3H), 3.82(s, 3H), 4.64(d, J=6.7Hz, 2H), 5.51(t, J=6.7Hz, 1H), 
               
               
                   
                 6.91(s, 1H), 6.95(s, 1H), 7.06(d, J=8.7Hz, 1H), 7.37(dd, J=8.7, 1.9Hz, 1H), 7.40–7.47(m, 2H), 7.50(d, J=2.4Hz, 1H), 7.57(d, J=1.9Hz, 1H), 
               
               
                   
                 IR(KBr)1523, 1496, 1370, 1213, 1175, 1116, 1035, 977, 832, 807cm −1   
               
               
                 I-464 
                 m.p.149–151° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.74(s, 3H), 2.55(q, J=7.0Hz, 2H), 3.21(s, 3H), 3.26(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 4.07(t, J=7.0Hz, 2H), 
               
               
                   
                 5.21(t, J=7.0Hz, 1H), 6.91(s, 1H), 6.94(s, 1H), 7.05(d, J=8.4Hz, 1H), 7.37(dd, J=8.4, 2.1Hz, 1H), 7.40–7.47(m, 2H), 7.50(d, J=2.1Hz, 1H), 
               
               
                   
                 7.57(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr)1523, 1495, 1368, 1212, 1176, 1116, 1035, 976, 832, 806cm −1   
               
               
                 I-465 
                 m.p. 148–150° C 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 3.11(s, 3H), 3.26(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.13(s, 2H), 6.91(s, 1H), 6.94(s, 1H), 7.12(d, J=8.4Hz, 
               
               
                   
                 1H), 7.22(d, J=7.8Hz, 2H), 7.35(d, J=7.8Hz, 2H), 7.37(dd, J=8.4, 1.8Hz, 1H), 7.40–7.50(m, 3H), 7.59(d, J=1.8Hz, 1H) 
               
               
                   
                 IR(KBr)1523, 1490, 1370, 1181, 1115, 971, 868, 806cm −1   
               
               
                 I-466 
                 m.p. 109–112° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.79(s, 6H), 4.62(d, J=6.9Hz, 2H), 5.26(d, J=3.9Hz, 1H), 5.52(t, J=6.9Hz, 1H), 5.72(s, 1H), 
               
               
                   
                 6.91(s, 1H), 6.93(d, J=8.6Hz, 1H), 6.94(s, 1H), 7.04(t, J=8.7Hz, 1H), 7.07(dd, J=8.6, 2.1Hz, 1H), 7.19(d, J=2.1Hz, 1H), 7.25(ddd, J=8.7, 
               
               
                   
                 1.8, 0.9Hz, 1H), 7.37(dd, J=12.0, 1.8Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )3578, 3542, 1526, 1495, 1280, 1055, 1035cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 95 
               
               
                   
               
             
            
               
                 I-467 
                 amorphous 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.39(s, 3H), 3.79(s, 6H), 5.11(s, 2H), 5.40(brs, 1H), 5.73(s, 1H), 6.91(s, 1H), 6.94(s, 1H), 6.99(d, J=8.4Hz, 1H), 7.04 
               
               
                   
                 (t, J=8.7Hz, 1H), 7.08(dd, J=8.4, 2.1Hz, 1H), 7.21(d, J=2.1Hz, 1H), 7.23(d, J=7.7Hz, 2H), 7.25(ddd, J=8.7, 2.1, 1.2Hz, 1H), 7.34(d, J=7.7Hz, 
               
               
                   
                 2H), 7.37(dd, J=11.7, 2.1Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )3577, 3545, 1526, 1495, 1280, 1055, 1035, 868cm −1   
               
               
                 I-468 
                 amorphous 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.75(s, 3H), 2.53(q, J=7.0Hz, 2H), 3.78(s, 3H), 3.79(s, 3H), 4.07(t, J=7.2Hz, 2H), 5.22(t, J=7.0Hz, 1H), 
               
               
                   
                 5.27(d, J=3.9Hz, 1H), 5.71(s, 1H), 6.91(s, 1H), 6.91(d, J=8.6Hz, 1H), 6.94(s, 1H), 7.04(t, J=8.4Hz, 1H), 7.06(dd, J=8.6, 2.1Hz, 1H), 7.19 
               
               
                   
                 (d, J=2.1Hz, 1H), 7.25(ddd, J=8.4, 1.9, 1.1Hz, 1H), 7.37(dd, J=12.0, 1.9Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )3578, 1526, 1495, 1280, 1055, 1035cm −1   
               
               
                 I-469 
                 m.p. 190–191° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 3.11(s, 3H), 3.19(s, 3H), 3.80(s, 6H), 5.13(s, 2H), 6.92(s, 1H), 6.94(s, 1H), 7.12(d, J=8.7Hz, 1H), 7.22(d, 
               
               
                   
                 J=7.8Hz, 1H), 7.32–7.37(m, 4H), 7.49(dd, J=2.1, 8.4Hz, 1H), 7.59(d, J=1.8Hz, 1H), 7.60–7.65(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1521, 1492, 1468, 1386, 1366, 1336, 1292, 1272, 1259, 1202, 1174, 1150, 1113cm −1   
               
               
                 I-470 
                 m.p. 147–148° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 3.19(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 5.16(s, 2H), 6.92(s, 1H), 6.93(s, 1H), 7.06(t, J=8.7Hz, 1H), 7.20–7.27 
               
               
                   
                 (m, 3H), 7.32–7.41(m, 5H), 7.60–7.64(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1523, 1492, 1462, 1454, 1379, 1359, 1299, 1278, 1264, 1210, 1175, 1151, 1129, 1054, 1031, 1009cm −1   
               
               
                 I-471 
                 m.p. 170–172° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.19(s, 3H), 3.24(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 5.12(s, 2H), 6.92(s, 1H), 6.94(s, 1H), 7.11(d, J=8.7Hz, 1H), 7.26–7.30 
               
               
                   
                 (m, 2H), 7.32–7.37(m, 2H), 7.47(dd, J=2.4, 8.4Hz, 1H), 7.61–7.64(m, 3H), 7.74–7.80(m, 1H), 8.61–8.63(m, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1522, 1491, 1462, 1361, 1296, 1264, 1212, 1177, 1149, 1115, 1030cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 96 
               
               
                   
               
             
            
               
                 I-472 
                 m.p. 174–175° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.19(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 5.33(s, 2H), 6.92(s, 1H), 6.93(s, 1H), 7.07(d, J=8.7Hz, 1H), 7.23–7.28(m, 2H), 7.32– 
               
               
                   
                 7.37(m, 2H), 7.41(dd, J=1.8, 12.6Hz, 1H), 7.60–7.64(m, 3H), 7.73–7.79(m, 1H), 8.60–8.63(m, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1524, 1491, 1464, 1380, 1361, 1302, 1267, 1209, 1172, 1149, 1130, 1034, 1024, 1008cm −1   
               
               
                 I-473 
                 m.p. 118.5–119.5° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.80(d, J=0.9Hz, 3H), 3.78(s, 3H), 3.79(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.52–5.57(m, 1H), 6.73–6.78(m, 2H), 
               
               
                   
                 6.91(s, 1H), 6.93(s, 1H), 7.02(t, J=8.7Hz, 1H), 7.25–7.30(m, 1H), 7.35–7.43(m, 3H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1625, 1527, 1491, 1461, 1449, 1378, 1298, 1279, 1259, 1207, 1184, 1125, 1055, 1031cm −1   
               
               
                 I-474 
                 m.p. 156–158° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 3.08(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.52–5.58(m, 1H), 6.43(brs, 1H), 
               
               
                   
                 6.93(s, 1H), 6.94(s, 1H), 7.03(t, J=8.4Hz, 1H), 7.26–7.30(m, 3H), 7.37(dd, J=1.8, 12.6Hz, 1H), 7.57–7.61(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1526, 1495, 1463, 1382, 1325, 1300, 1267, 1210, 1156, 1139, 1129, 1054, 1032cm −1   
               
               
                 I-475 
                 m.p. 158–160° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 3.80(s, 6H), 4.64(d, J=6.6Hz, 2H), 4.73(brs, 2H), 5.53–5.57(m, 1H), 6.51(brs, 1H), 6.93(s, 1H), 
               
               
                   
                 6.94(s, 1H), 7.03(t, J=8.7Hz, 1H), 7.26–7.31(m, 3H), 7.37(dd, J=2.1, 12.6Hz, 1H), 7.57–7.61(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1527, 1495, 1462, 1395, 1326, 1299, 1264, 1208, 1170, 1130, 1054, 1031cm −1   
               
               
                 I-476 
                 m.p. 138–140° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.21(s, 3H), 3.78(s, 3H), 3.80(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.53–5.57(m, 1H), 6.93(s, 1H), 6.94 
               
               
                   
                 (s, 1H), 7.03(t, J=8.4Hz, 1H), 7.20(brs, 1H), 7.26–7.30(m, 1H), 7.37(dd, J=2.1, 12.6Hz, 1H), 7.56(m, 4H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1666, 1604, 1527, 1494, 1463, 1448, 1379, 1317, 1299, 1264, 1209, 1130, 1055, 1032cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 97 
               
               
                   
               
             
            
               
                 I-477 
                 m.p. 200–202° C. 
               
               
                   
                   1 HNMR(CDCl 3  + CD 3 OD) δ 1.77(s, 3H), 1.81(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.52–5.57(m, 1H), 6.93(s, 1H), 6.94 
               
               
                   
                 (s, 1H), 7.03(t, J=9.0Hz, 1H), 7.27–7.30(m, 1H), 7.34–7.41(m, 3H), 7.52–7.55(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 2404, 1684, 1660, 1584, 1528, 1493, 1462, 1386, 1301, 1274, 1263, 1209, 1132, 1053, 1029cm −1   
               
               
                 I-478 
                 m.p. 195–196.5° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.55(s, 9H), 3.78(s, 3H), 3.79(s, 3H), 4.85(s, 1H), 6.75(brs, 1H), 6.88–6.92(m, 2H), 6.92(s, 1H), 6.93(s, 1H), 7.31–7.39 
               
               
                   
                 (m, 3H), 7.45–7.49(m, 2H), 8.12(t, J=7.5Hz, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1729, 1590, 1531, 1500, 1464, 1394, 1261, 1240, 1199, 1156, 1055, 1033, 1023cm −1   
               
               
                 I-479 
                 m.p. 172–174° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.55(s, 9H), 3.19(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 6.75(d, J=2.1Hz, 1H), 6.92(s, 1H), 6.94(s, 1H), 7.26–7.39(m, 5H), 7.60– 
               
               
                   
                 7.65(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1728, 1590, 1531, 1513, 1494, 1464, 1391, 1367, 1352, 1240, 1206, 1179, 1145, 1056, 1033, 1024cm −1   
               
               
                 I-480 
                 m.p. 152–153° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.74(s, 3H), 1.77(s, 3H), 3.18(s, 3H), 3.78(d, J=9.9Hz, 2H), 3.79(s, 6H), 3.93(brs, 1H), 5.35–5.40(m, 1H), 6.75(t, J=8.4Hz, 
               
               
                   
                 1H), 6.91(s, 1H), 6.95(s, 1H), 7.24–7.36(m, 4H), 7.60–7.65(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1630, 1530, 1488, 1466, 1380, 1366, 1346, 1259, 1213, 1176, 1149, 1124, 1054, 1027cm −1   
               
               
                 I-481 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.40(s, 3H), 3.19(s, 3H), 3.77(s, 3H), 3.78(s, 3H), 6.80(t, d=2.4Hz, 1H), 6.90(s, 1H), 6.91(s, 1H), 7.25–7.36(m, 6H), 7.58– 
               
               
                   
                 7.65(m, 3H), 7.72–7.76(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1522, 1490, 1366, 1342, 1211, 1164, 1151, 1091, 1053, 1030cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 98 
               
               
                   
               
             
            
               
                 I-482 
                 m.p. 201–203° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.45(s, 3H), 3.20(s, 3H), 3.82(s, 6H), 6.95(s, 1H), 6.98(s, 1H), 7.32–7.48(m, 6H), 7.61–7.66(m, 2H), 7.80–7.84(m, 2H), 
               
               
                   
                 8.10(d, J=3.3Hz, 1H), 8.55(d, J=8.4Hz, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1671, 1592, 1524, 1494, 1388, 1366, 1328, 1265, 1207, 1172, 1150, 1052, 1024cm −1   
               
               
                 I-483 
                 m.p. 132–134° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.55(s, 9H), 3.00(s, 6H), 3.79(s, 6H), 6.73(d, J=2.4Hz, 1H), 6.81(m, 2H), 6.92(s, 1H), 6.96(s, 1H), 7.32–7.39(m, 2H), 
               
               
                   
                 7.48–7.52(m, 2H), 8.11(t, J=8.1Hz, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1728, 1610, 1591, 1533, 1499, 1459, 1446, 1381, 1365, 1238, 1206, 1159, 1055, 1030cm −1   
               
               
                 I-484 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.74(s, 3H), 1.77(s, 3H), 3.00(s, 6H), 3.78(d, J=9.6Hz, 1H), 3.78(s, 3H), 3.79(s, 3H), 5.34–5.38(m, 1H), 6.75(t, J=8.4Hz, 
               
               
                   
                 1H), 6.92(s, 1H), 6.94(s, 1H), 6.93–6.95(m, 1H), 7.23–7.32(m, 3H), 7.48–7.52(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1625, 1611, 1531, 1494, 1446, 1380, 1340, 1257, 1207, 1123, 1055, 1032cm −1   
               
               
                 I-485 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.40(s, 3H), 3.00(s, 6H), 3.76(s, 3H), 3.77(s, 3H), 6.70(t, J=2.4Hz, 1H), 6.80(t, J=8.7Hz, 2H), 6.87(s, 1H), 6.94(s, 1H), 
               
               
                   
                 7.24–7.33(m, 4H), 7.46–7.50(m, 2H), 7.60(t, J=9.0Hz, 1H), 7.71–7.75(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1609, 1529, 1493, 1446, 1381, 1340, 1208, 1164, 1090, 1054, 1031cm −1   
               
               
                 I-486 
                 m.p. 184–186° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.45(s, 3H), 3.01(s, 6H), 3.80(s, 3H), 3.81(s, 3H), 6.82(d, J=7.5Hz, 2H), 6.95(s, 1H), 6.98(s, 1H), 7.32(d, J=8.1Hz, 2H), 
               
               
                   
                 7.40–7.52(m, 4H), 7.80–7.84(m, 2H), 8.08(d, J=2.7Hz, 1H), 8.52(t, J=8.4Hz, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1647, 1608, 1530, 1497, 1379, 1365, 1284, 1267, 1206, 1051, 1030cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 99 
               
               
                   
               
             
            
               
                 I-487 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.36(s, 3H), 3.77(s, 6H), 4.81(brs, 1H), 6.69(dd, J=0.9, 3.6Hz, 1H), 6.88–6.92(m, 2H), 6.94(s, 1H), 6.95(s, 1H), 7.23–7.26 
               
               
                   
                 (m, 2H), 7.46–7.51(m, 2H), 7.53(dd, J=1.5, 8.4Hz, 1H), 7.59(d, J=3.6Hz, 1H), 7.73(d, J=0.9Hz, 1H), 7.80–7.84(m, 2H), 8.02(d, J=8.4Hz, 
               
               
                   
                 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1611, 1594, 1520, 1498, 1459, 1444, 1369, 1259, 1208, 1170, 1129, 1092, 1051, 1028cm −1   
               
               
                 I-488 
                 m.p. 219–220° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 3.19(s, 3H), 3.78(s, 3H), 3.79(s, 3H), 6.70(dd, J=0.9, 3.6Hz, 1H), 6.94(s, 1H), 6.97(s, 1H), 7.24–7.27(m, 2H), 
               
               
                   
                 7.32–7.37(m, 2H), 7.53(dd, J=1.8, 8.7Hz, 1H), 7.60(d, J=3.6Hz, 1H), 7.61–7.66(m, 2H), 7.73(d, J=0.9Hz, 1H), 7.80–7.84(m, 2H), 8.03 
               
               
                   
                 (d, J=8.7Hz, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1513, 1494, 1464, 1444, 1373, 1209, 1173, 1155, 1122, 1049cm −1   
               
               
                 I-489 
                   1 HNMR(CDCl 3 ) δ 3.79(s, 3H), 3.80(s, 3H), 3.94(s, 3H), 5.17(s, 2H), 5.71(s, 1H), 6.96(s, 1H), 6.97(s, 1H), 6.99(d, J=8.7Hz, 1H), 7.09(d.d, 
               
               
                   
                 J=8.7&amp;2.4Hz, 1H), 7.22(d, J=2.4Hz), 7.26(s, 1H), 7.32–7.49(m, 5H), 7.66(d, J=8.7Hz, 2H), 8.09(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3383, 1702, 1606, 1489, 1381, 1291, 1206, 1111, 1032, 1002cm −1   
               
               
                 I-490 
                   1 HNMR(CDCl 3 ) δ 3.12(s, 3H), 3.79(s, 3H), 3.81(s, 3H), 3.95(s, 3H), 5.18(s, 2H), 6.96(s, 2H), 7.12(d, J=8.4Hz, 1H), 7.31–7.53(m, 6H), 7.60 
               
               
                   
                 (d, J=2.1Hz, 1H), 7.65(d, J=8.7Hz, 2H), 8.10(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)1720, 1607, 1492, 1362, 1275, 1211, 1112, 1057, 1032cm −1   
               
               
                 I-491 
                   1 HNMR(CDCl 3 ) δ 3.12(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.18(s, 2H), 6.92(s, 1H), 6.96(s, 1H), 7.13(d, J=8.4Hz, 1H), 7.31–7.52(m, 6H), 7.70 
               
               
                   
                 (d, J=2.1Hz, 1H), 7.66–7.77(m, 4H) 
               
               
                   
                 IR(KBr)3433, 1685, 1606, 1509, 1492, 1372, 1318, 1264, 1211, 1183, 1111, 1055, 1031cm −1   
               
               
                 I-492 
                   1 HNMR(CDCl 3 ) δ 3.79(s, 3H), 3.80(s, 3H), 5.17(s, 2H), 5.71(s, 2H), 6.91(s, 1H), 6.97(s, 1H), 7.00(d, J=8.4Hz, 1H), 7.08(dd, J=8.4&amp;2.4Hz, 
               
               
                   
                 1H), 7.22(d, J=2.4Hz, 1H), 7.32–7.49(m, 5H), 7.70(s, 4H) 
               
               
                   
                 IR(KBr)3291, 2242, 1607, 1579, 1488, 1384, 1324, 1272, 1209, 1130, 1054, 1034, 1001cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 100 
               
               
                   
               
             
            
               
                 I-493 
                   1 HNMR(CDCl 3 ) δ 3.12(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.18(s, 2H), 6.92(s, 1H), 6.96(s, 1H), 7.12(d, J=8.4Hz, 1H), 7.31–7.72(m, 6H), 7.60 
               
               
                   
                 (d, J=1.8Hz, 1H), 7.65–7.74(m, 4H) 
               
               
                   
                 IR(KBr)2223, 1604, 1490, 1363, 1296, 1264, 1213, 1172, 1117, 1055, 1036, 1026cm −1   
               
               
                 I-494 
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 3.23(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 3.95(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.51(t, J=6.6Hz, 1H), 
               
               
                   
                 6.96(s, 2H), 7.06(d, J=8.7Hz, 1H), 7.50(d.d, J=8.7&amp;2.1Hz, 1H), 7.59(d, J=2.1Hz, 1H), 7.65(d, J=8.7Hz, 2H), 8.10(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)1720, 1608, 1508, 1492, 1384, 1357, 1273, 1179, 1110, 1026, 1019cm −1   
               
               
                 I-495 
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 3.12(s, 3H), 3.80(s, 6H), 3.81(s, 3H), 3.95(s, 3H), 5.14(s, 2H), 6.96(s, 2H), 7.13(d, J=8.4Hz, 1H), 7.21(d, 
               
               
                   
                 J=7.8Hz, 2H), 7.35(d, J=7.8Hz, 2H), 7.49(d.d, J=8.4&amp;1.8Hz, 1H), 7.60(d, J=1.8Hz, 1H), 7.65(d, J=8.7Hz, 2H), 8.10(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)1697, 1607, 1492, 1364, 1286, 1263, 1213, 1178, 11115, 1057, 1030cm −1   
               
               
                 I-496 
                 IR(KBr)1730, 1701, 1610, 1515, 1465, 1359, 1238, 1186, 1116, 1082, 1064, 1016cm −1   
               
               
                 I-497 
                   1 HNMR(CDCl 3 ) δ 1.75(s, 3H), 1.80(s, 3H), 2.89(s, 6H), 3.21(s, 3H), 3.44(s, 3H), 3.68(s, 3H), 3.77(s, 1H), 4.61(d, J=8.4Hz, 2H), 5.49(t, J= 
               
               
                   
                 8.4Hz, 1H), 6.92(s, 1H), 7.01(d, J=8.4Hz, 1H), 7.25–7.28(m, 3H), 7.33(d, J=2.1Hz, 1H), 7.52(dd, J=8.4&amp;1.8Hz, 1H), 7.66(d, J=2.4Hz, 
               
               
                   
                 1H) 
               
               
                   
                 IR(KBr)1727, 1598, 1515, 1467, 1360, 1295, 1258, 1241, 1116, 1084cm −1   
               
               
                 I-498 
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 2.89(s, 6H), 3.10(s, 3H), 3.44(s, 3H), 3.66(s, 3H), 3.77(s, 3H), 5.11(s, 3H), 6.93(s, 1H), 7.06–7.15(m, 2H), 
               
               
                   
                 7.17–7.29(m, 4H), 7.31–7.37(m, 3H), 7.53(d.d, J=8.7&amp;1.8Hz, 1H), 7.66(dJ=1.8Hz, 1H) 
               
               
                   
                 IR(KBr)1732, 1701, 1598, 1518, 1466, 1352, 1294, 1121, 1085, 1060, 1015cm −1   
               
               
                 I-499 
                   1 HNMR(CDCl 3 ) δ 2.88(s, 6H), 3.44(s, 3H), 3.64(s, 3H), 3.77(s, 3H), 5.17(s, 2H), 5.65(s, 1H), 6.84(dd, J=8.1&amp;2.1Hz, 1H), 6.92(s, 1H), 6.95 
               
               
                   
                 (d, J=8.1Hz, 1H), 7.01(d, J=2.1Hz, 1H), 7.12(d, J=8.4Hz, 1H), 7.31–7.46(m, 6H), 7.53(d.d, J=8.4&amp;1.8Hz, 1H), 7.66(d, J=1.8Hz, 1H) 
               
               
                   
                 IR(KBr)3526, 3434, 1732, 1598, 1515, 1460, 1344, 1260, 1240, 1222, 1061, 1013cm − 1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 101 
               
               
                   
               
             
            
               
                 I-500 
                   1 HNMR(CDCl 3 ) δ 2.60(s, 3H), 3.43(s, 3H), 3.72(s, 3H), 3.75(s, 3H), 5.17(s, 2H), 5.67(s, 1H), 6.77(s, 1H), 6.94(dd, J=8.4&amp;1.8Hz, 1H), 7.02 
               
               
                   
                 (d, J=8.4Hz, 1H), 7.06(d, J=1.8Hz, 1H), 7.32–7.50(m, 7H), 7.53–7.62(m, 1H), 7.94(d, J=7.8Hz, 1H) 
               
               
                   
                 IR(KBr)1732, 1719, 1585, 1521, 1481, 1403, 1352, 1289, 1253, 1225, 1172, 1073, 1012cm −1   
               
               
                 I-501 
                   1 HNMR(CDCl 3 ) δ 2.73(s, 3H), 3.12(s, 3H), 3.43(s, 3H), 3.72(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.78(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.31–7.63 
               
               
                   
                 (m, 10H), 9.96(d, J=6.6Hz, 1H) 
               
               
                   
                 IR(KBr)1726, 1609, 1520, 1480, 1400, 1371, 1294, 1262, 1179, 1075, 1009cm −1   
               
               
                 I-502 
                   1 HNMR(CDCl 3 ) δ 1.78(s, 3H), 1.81(s, 3H), 3.22(s, 3H), 3.48(s, 3H), 3.71(s, 3H), 3.77(s, 3H), 3.82(s, 3H), 4.66(d, J=6.9Hz, 2H), 5.56(t, 
               
               
                   
                 J=6.9Hz, 1H), 6.62(s, 1H), 6.70(s, 1H), 7.11(s, 1H), 7.38(d, J=8.7Hz, 1H), 7.69(d, J=8.7Hz, 1H) 
               
               
                   
                 IR(KBr)1699, 1607, 1587, 1516, 1468, 1354, 1216, 1152, 1067, 1044, 1004cm −1   
               
               
                 I-503 
                   1 HNMR(CDCl 3 ) δ 1.78(s, 3H), 1.81(s, 3H), 3.21(s, 3H), 3.48(s, 3H), 3.72(s, 3H), 3.74(s, 3H), 3.82(s, 3H), 4.33(d, J=11.7Hz, 1H), 4.54(d, 
               
               
                   
                 J=11.7Hz, 1H), 4.65(d, J=8.4Hz, 1H), 5.57(t, J=8.4Hz, 1H), 6.68(s, 1H), 6.69(s, 1H), 6.89(s, 1H), 7.38(d, J=8.7Hz, 2H), 7.73(d, J=8.7Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr)3530, 1609, 1515, 1467, 1356, 1214, 1174, 1151, 1075, 1039, 1004cm −1   
               
               
                 I-504 
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.80(s, 3H), 3.22(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 3.77(s, 3H), 3.81(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.55(t, J= 
               
               
                   
                 6.9Hz, 1H), 6.64(s, 1H), 6.77(s, 1H), 6.97(s, 1H), 7.39(d, J=8.7Hz, 2H), 7.72(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3431, 1735, 1706, 1609, 1514, 1474, 1367, 1206, 1176, 1150, 1055, 1039cm −1   
               
               
                 I-505 
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.80(s, 3H), 2.94(broad, 1H), 3.47(s, 3H), 3.72(s, 3H), 3.73(s, 3H), 3.81(s, 3H), 4.32(s, 1H), 4.36(s, 1H), 4.65 
               
               
                   
                 (d, J=6.6Hz, 2H), 5.34(s, 1H), 5.57(t, J=6.6Hz, 1H), 6.69(s, 1H), 6.70(s, 1H), 6.89(s, 1H), 6.91(d, J=8.1Hz, 2H), 7.55(d, J=8.1Hz, 2H) 
               
               
                   
                 IR(KBr)3466, 1610, 1517, 1475, 1463, 1386, 1265, 1215, 1170, 1147, 1075, 1042, 1007cm −1   
               
               
                 I-506 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.79(s, 3H), 3.44(s, 3H), 3.74(s, 3H), 3.76(s, 3H), 3.80(s, 3H), 4.63(d, J=7.2Hz, 2H), 5.30(s, 1H), 5.49–5.60 
               
               
                   
                 (m, 1H), 6.63(s, 1H), 6.78(s, 1H), 6.94(d, J=8.7Hz, 2H), 6.97(s, 1H), 7.54(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3382, 1726, 1699, 1611, 1519, 1470, 1206, 1174, 1143, 1074, 1056, 997cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 102 
               
               
                   
               
             
            
               
                 I-507 
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.79(s, 3H), 3.41(s, 3H), 3.60(s, 3H), 3.74(s, 3H), 3.77(s, 3H), 3.81(s, 3H), 4.63(d, J=6.9Hz, 2H), 
               
               
                   
                 4.74–5.02(broad, 1H), 5.52–5.60(m, 1H), 6.63(s, 1H), 6.75(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.94(s, 1H), 7.54(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3423, 1734, 1612, 1520, 1475, 1441, 1395, 1337, 1267, 1215, 1173, 1140, 1017cm −1   
               
               
                 I-508 
                   1 HNMR(CDCl 3 ) δ 3.21(s, 3H), 3.45(s, 3H), 3.73(s, 3H), 4.41–4.62(m, 2H), 5.16(s, 2H), 5.71(s, 1H), 6.79(d.d, J=8.1&amp;2.1Hz, 1H), 6.84(s, 
               
               
                   
                 1H), 6.92(d, J=2.1Hz, 1H), 7.01(d, J=8.1Hz, 1H), 7.32–7.50(m, 7H), 7.71(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3496, 3255, 1607, 1590, 1528, 1473, 1464, 1358, 1247, 1147, 1071, 1017cm −1   
               
               
                 I-509 
                   1 HNMR(CDCl 3 ) δ 3.21(s, 3H), 3.45(s, 3H), 3.73(s, 3H), 3.89(s, 3H), 4.51(d, J=6.3Hz, 2H), 5.20(s, 2H), 6.80(d.d, J=8.1&amp;2.1Hz, 1H), 6.85 
               
               
                   
                 (s, 1H), 6.89(d, J=2.1Hz, 1H), 6.97(d, J=8.1Hz, 1H), 7.29–7.51(m, 7H), 7.71(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3412, 1603, 1586, 1515, 1464, 1364, 1242, 1175, 1151, 1081, 1020, 1006cm −1   
               
               
                 I-510 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(s, 3H), 3.22(s, 3H), 3.45(s, 3H), 3.73(s, 3H), 3.87(s, 3H), 4.52(s, 2H), 4.64(d, J=6.6Hz, 2H), 5.57(t,  
               
               
                   
                 J=6.6Hz, 1H), 6.83(dd, J=7.5&amp;1.2Hz, 1H), 6.86(d, J=1.2Hz, 1H), 6.96(d, J=7.5Hz, 1H) 
               
               
                   
                 IR(KBr)3433, 1598, 1579, 1517, 1469, 1372, 1244, 1221, 1174, 1149, 1072, 1017cm −1   
               
               
                 I-511 
                   1 HNMR(CDCl 3 ) δ 2.36(s, 3H), 3.21(s, 3H), 3.45(s, 3H), 3.72(s, 3H), 3.88(s, 3H), 4.50(s, 2H), 5.16(s, 2H), 6.80(dd, J=8.1&amp;2.1Hz, 1H), 6.85 
               
               
                   
                 (s, 1H), 6.88(d, J=2.1Hz, 1H), 6.97(d, J=8.1Hz, 1H), 7.20(d, J=8.4Hz, 2H), 7.33–7.42(m, 4H), 7.71(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3502, 1604, 1510, 1465, 1383, 1360, 1266, 1239, 1227, 1147, 1071, 1008cm −1   
               
               
                 I-512 
                   1 HNMR(CDCl 3 ) δ 3.45(s, 3H), 3.72(s, 3H), 3.89(s, 3H), 4.48(s, 2H), 5.20(s, 2H), 6.81(dd, J=8.1&amp;2.1Hz, 1H), 6.86(s, 1H), 6.88–6.99 
               
               
                   
                 (m, 4H), 7.27–7.43(m, 3H), 7.46–7.54(m, 4H) 
               
               
                   
                 IR(KBr)3528, 1610, 1591, 1517, 1474, 1461, 1438, 1388, 1263, 1239, 1173, 1140, 1017cm −1   
               
               
                 I-513 
                   1 HNMR(CDCl 3 ) δ 1.75(s, 3H), 1.79(s, 3H), 2.47(broads, 1H), 3.45(s, 3H), 3.73(s, 3H), 3.86(s, 3H), 4.52(s, 2H), 4.63(d, J=6.6Hz, 2H), 5.16 
               
               
                   
                 (s, 1H), 5.56(d, J=6.6Hz, 1H), 6.82–6.97(m, 6H), 7.53(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3477, 3246, 1609, 1586, 1518, 1464, 1439, 1387, 1266, 1240, 1221, 1173, 1141, 1079, 1011, 1002cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 103 
               
               
                   
               
             
            
               
                 I-514 
                   1 HNMR(CDCl 3 ) δ 2.36(s, 3H), 2.48(broad, 1H), 3.44(s, 3H), 3.72(s, 3H), 3.88(s, 3H), 4.50(s, 2H), 5.16(s, 3H), 6.76–6.98(m, 6H), 
               
               
                   
                 7.19(d, J=7.8Hz, 2H), 7.36(d, J=7.8Hz, 2H), 7.52(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3544, 3239, 1614, 1593, 1519, 1463, 1386, 1266, 1240, 1218, 1173, 1139, 1074, 1010cm −1   
               
               
                 I-515 
                 m.p. 159–160° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.19(s, 3H), 3.34(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 5.18(ABq, J=12.3Hz, 2H), 6.92(s, 1H), 6.93(s, 1H), 7.08(d, J=8.7Hz, 
               
               
                   
                 1H), 7.33–7.64(m, 11H) 
               
               
                   
                 IR(KBr)3433, 2937, 1694, 1520, 1492, 1369, 1288, 1243, 1211, 1176, 1150, 1100cm −1   
               
               
                 I-516 
                   1 HNMR(CDCl 3 ) δ 2.91(s, 3H), 3.777(s, 3H), 3.783(s, 3H), 4.85(brs, 1H), 5.12(s, 2H), 6.87–7.00(m, 7H), 7.32–7.50(m, 7H) 
               
               
                   
                 IR(KBr)3432, 2938, 1609, 1590, 1525, 1494, 1380, 1254, 1207, 1174, 1152, 1058, 1031cm −1   
               
               
                 I-517 
                 m.p. 213–215° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.99(s, 3H), 3.779(s, 3H), 3.804(s, 3H), 4.86(brs, 1H), 5.16(s, 2H), 6.83(brs, 1H), 6.93(s, 1H), 6.94(s, 1H), 7.06(d, J=8.7Hz, 
               
               
                   
                 1H), 7.35(dd, J=2.1, 8.7Hz, 1H), 7.41–7.49(m, 7H), 7.81(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr)3409, 3374, 1610, 1525, 1491, 1371, 1321, 1251, 1208, 1145, 1120, 1037cm −1   
               
               
                 I-518 
                 powder 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.75(s, 3H), 1.81(s, 3H), 2.84(s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 3.93(s, 3H), 4.67(d, J=7.2Hz, 
               
               
                   
                 2H), 5.59(m, 1H), 6.85(s, 1H), 7.36–7.42(m, 2H), 7.62(d, J=2.1Hz, 1H), 7.65–7.70(m, 2H), 7.86(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )3026, 2940, 1728, 1510, 1473, 1373, 1179, 1150, 1086cm −1   
               
               
                 I-519 
                 powder 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.74(s, 3H), 2.52–2.61(m, 2H), 2.86(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 3.93(s, 3H), 
               
               
                   
                 4.21(t, J=6.9Hz, 2H), 5.26(m, 1H), 6.86(s, 1H), 7.36–7.42(m, 2H), 7.62(d, J=2.1Hz, 1H), 7.65–7.70(m, 2H), 7.86(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )3024, 2939, 1729, 1511, 1475, 1447, 1373, 1179, 1150, 1085cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 104 
               
               
                   
               
             
            
               
                 I-520 
                 powder 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.84(s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.56(s, 3H), 3.81(s, 3H), 3.88(s, 3H), 5.30(s, 2H), 6.86(s, 1H), 7.26–7.32(m, 1H), 
               
               
                   
                 7.37–7.42(m, 2H), 7.65–7.72(m, 4H), 7.76–7.83(m, 1H), 7.92(d, J=2.1Hz, 1H), 8.60–8.63(m, 1H) 
               
               
                   
                 IR(KBr)3434, 3019, 2940, 1730, 1511, 1474, 1367, 1178, 1151, 1082cm −1   
               
               
                 I-521 
                 powder 
               
               
                   
                   1 HNMR(CDCl 3  + CD 3 OD) δ 1.69(s, 3H), 1.77(s, 3H), 2.51–2.58(m, 2H), 3.43(s, 3H), 3.73(s, 3H), 4.23(t, J=6.6Hz, 2H), 6.44(s, 1H), 
               
               
                   
                 6.89–6.95(m, 2H), 7.24(d, J=1.8Hz, 1H), 7.46–7.52(m, 2H), 7.65–7.67(m, 1H) 
               
               
                   
                 IR(KBr)3434, 2934, 1716, 1611, 1402, 1226, 1116, 1082, 1027cm −1   
               
               
                 I-522 
                 m.p. 240–243° C. 
               
               
                   
                   1 HNMR(CDCl 3  + CD 3 OD) δ 3.44(s, 3H), 3.75(s, 3H), 5.31(s, 2H), 6.46(s, 1H), 6.89–6.95(m, 2H), 7.30–7.31(m, 1H), 7.35–7.42(m, 2H), 
               
               
                   
                 7.47–7.53(m, 2H), 7.56(d, J=2.4Hz, 1H), 7.79–7.86(m, 1H), 8.65–8.68(m, 1H) 
               
               
                   
                 IR(KBr)3411, 2937, 1683, 1611, 1521, 1406, 1230, 1115, 1082, 1026cm −1   
               
               
                 I-523 
                 m.p. 136–137° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.25(s, 3H), 2.29(s, 3H), 3.12(s, 3H), 3.20(s, 3H), 5.18(s, 2H), 7.11(s, 1H), 7.14(s, 1H), 7.23–7.51(m, 12H) 
               
               
                   
                 IR(KBr)1518, 1488, 1357, 1263, 1170, 1150, 1110, 970, 873, 848, 809cm −1   
               
               
                 I-524 
                 m.p. 121–122° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.25(s, 3H), 2.29(s, 3H), 3.20(s, 3H), 3.23(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.52(t, J=6.6Hz, 1H), 
               
               
                   
                 7.06(d, J=8.4Hz, 1H), 7.11(s, 1H), 7.14(s, 1H), 7.24(d, J=2.1Hz, 1H), 7.31–7.45(m, 5H) 
               
               
                   
                 IR(KBr)1518, 1487, 1363, 1170, 1150, 1108, 970, 869, 848, 808cm −1   
               
               
                 I-525 
                 m.p. 149–151° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.83(d, J=0.6Hz, 3H), 2.26(s, 3H), 2.28(s, 3H), 4.62(d, J=6.9Hz, 2H), 4.80(s, 1H), 5.53(m, 1H), 5.72(s, 1H), 
               
               
                   
                 6.82(dd, J=2.1, 8.4Hz, 1H), 6.85–6.94(m, 3H), 6.96(d, J=2.1Hz, 1H), 7.10(s, 1H), 7.12(s, 1H), 7.21–7.28(m, 2H) 
               
               
                   
                 IR(KBr)3521, 3395, 1612, 1584, 1522, 1490, 1457, 1285, 1263, 1242, 1200, 1170, 1125, 1014, 834cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 105 
               
               
                   
               
             
            
               
                 I-526 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.43(s, 3H), 2.76(s, 3H), 2.90(s, 3H), 3.22(s, 3H), 3.56(s, 3H), 3.80(s, 3H), 5.30(s, 2H), 6.28(t, J=3.3Hz, 1H), 6.42(dd, 
               
               
                   
                 J=3.3, 1.6Hz, 1H), 6.85(s, 1H), 7.12, (d, J=8.4Hz, 1H), 7.32(d, J=8.7Hz, 2H), 7.34–7.37(m, 2H), 7.39(d, J=8.7Hz, 2H), 7.40(d, J= 
               
               
                   
                 1.8Hz, 1H), 7.69(d, J=8.7Hz, 2H), 7.78(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)1608, 1597, 1519, 1480, 1464, 1176, 1152, 1087, 972, 875, 817, 798cm −1   
               
               
                 I-527 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.96(s, 3H), 3.21(s, 3H), 3.37(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 5.58(s, 2H), 6.84(s, 1H), 7.19(d, J=8.4Hz, 1H), 7.24–7.28 
               
               
                   
                 (m, 4H), 7.31, (dd, J=8.4, 1.8Hz, 1H), 7.33(d, J=1.8Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)1664, 1609, 1519, 1480, 1457, 1176, 1151, 1079, 970, 947, 876, 798, 748cm −1   
               
               
                 I-528 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.73(s, 3H), 2.94(s, 3H), 3.21(s, 3H), 3.33(t, J=6.3Hz, 2H), 3.55(s, 3H), 3.77(s, 3H), 4.55(t, J=6.3Hz, 2H), 6.83(s, 1H), 
               
               
                   
                 7.14(d, J=8.1Hz, 1H), 7.18(brdd, J=7.8, 5.1Hz, 1H), 7.33(brd, J=7.8Hz, 1H), 7.35(dd, J=8.1, 1.8Hz, 1H), 7.37(d, J=1.8Hz, 1H), 7.38(d, 
               
               
                   
                 J=8.7Hz, 2H), 7.65(m, 1H), 7.67(d, J=8.7Hz, 2H), 8.56(brd, J=5.1Hz, 1H) 
               
               
                   
                 IR(Nujol)1608, 1593, 1520, 1479, 1466, 1177, 1151, 1079, 970, 872, 816, 798cm −1   
               
               
                 I-529 
                 m.p. 203–205° C. 
               
               
                   
                 HNMR(DMSO-d 6 ) δ 2.42(s, 3H), 2.80(s, 3H), 3.45(s, 3H), 3.51(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.36(s, 2H), 7.07(s, 1H), 7.23(s, 1H), 
               
               
                   
                 7.26–7.28(m, 3H), 7.48, (d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)1599, 1518, 1480, 1466, 1176, 1081, 1013, 976, 870, 830, 797, 755cm −1   
               
               
                 I-530 
                 foam 
               
               
                   
                   1 HNMR(CD 3 OD) δ 3.38(s, 3H), 3.68(s, 3H), 5.41(s, 2H), 6.44(s, 1H), 6.82(dd, J=8.4, 2.1Hz, 1H), 6.85(d, J=8.7Hz, 2H), 6.93(d, J=2.1Hz, 
               
               
                   
                 1H), 7.06(d, J=8.4Hz, 1H), 7.27(m, 2H), 7.46(d, J=8.7Hz, 2H), 7.60(m, 2H) 
               
               
                   
                 IR(Nujol)3304, 161, 1590, 1522, 1488, 1458, 1254, 1115, 1074, 1046, 1014, 942, 825, 745cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 106 
               
               
                   
               
             
            
               
                 I-531 
                 m.p. 159–162° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.92(s, 3H), 3.41(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.79(s, 3H), 5.33(s, 2H), 7.09(s, 1H), 6.82–7.45(m, 3H), 7.49(d, 
               
               
                   
                 J=9.0Hz, 2H), 7.75(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(Nujol)1604, 1519, 1481, 1469, 1235, 1171, 1154, 1085, 1012, 967, 874, 849, 798cm −1   
               
               
                 I-532 
                 m.p. 214–216° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.84(s, 3H), 3.42(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.73(s, 3H), 3.79(s, 3H), 4.99(s, 2H), 7.08(s, 1H), 7.24(dJ=9.3Hz, 
               
               
                   
                 1H), 7.29(dd, J=9.3, 1.8Hz, 1H), 7.30(d, J=1.8Hz, 1H), 7.48(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)1767, 1606, 1521, 1481, 1463, 1216, 1175, 1151, 1080, 1013, 977, 946, 878, 821, 798cm −1   
               
               
                 I-533 
                 m.p. 225–227° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.86(s, 3H), 3.45(s, 3H), 3.46(s, 3H), 3.52(s, 3H), 3.78(s, 3H), 4.46(s, 2H), 7.08(s, 1H), 7.20(d, J=8.4Hz, 1H), 7.28–7.32 
               
               
                   
                 (m, 2H), 7.48(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3340, 1677, 1619, 1519, 1477, 1463, 1443, 1176, 1150, 1088, 971, 871, 829, 794cm −1   
               
               
                 I-534 
                 foam 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.96(s, 3H), 3.45(s, 3H), 3.47(s, 3H), 3.52(s, 3H), 3.79(s, 3H), 4.64(s, 2H), 7.08(s, 1H), 7.18(d, J=8.4Hz, 1H), 7.31 
               
               
                   
                 (dd, J=8.4, 1.8Hz, 1H), 7.34(d, J=1.8Hz, 1H), 7.48(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3464, 3362, 1693, 1606, 1520, 1481, 1176, 1151, 1080, 876, 822, 799cm −1   
               
               
                 I-535 
                 m.p. 163–165° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.73(s, 3H), 3.16(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 4.85(ddd, J=1.5, 1.5, 5.4Hz, 2H), 5.25(s, 2H), 5.31, (dd 
               
               
                   
                 d, J=1.5, 3.0, 10.5Hz, 1H), 5.43(ddd, J=1.5, 3.0, 17.1Hz, 1H), 6.05(ddd, J=5.4, 10.5, 17.1Hz, 1H), 6.84(s, 1H), 7.11(d, J=8.7Hz, 1H), 7.34 
               
               
                   
                 (dd, J=2.1, 8.7Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.56(d, J=8.4Hz, 2H), 7.67(d, J=8.4Hz, 2H), 8.11(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1718, 1612, 1519, 1481, 1365, 1273, 1177, 1151, 1119, 1080, 1015, 969, 876cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 107 
               
               
                   
               
             
            
               
                 I-536 
                 m.p. 115–117° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.68(s, 3H), 3.13(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.68(s, 2H), 3.78(s, 3H), 4.61(ddd, J=1.5, 1.5, 5.7Hz, 2H), 5.17(s, 2H), 
               
               
                   
                 5.23, (ddd, J=1.5, 3.0, 10.5,Hz, 1H), 5.28(ddd, J=1.5, 3.0, 16.8Hz, 1H), 5.91(ddd, J=5.7, 10.5, 16.8Hz, 1H), 6.84(s, 1H), 7.13(d, J=8.4Hz, 
               
               
                   
                 1H), 7.33(d, J=8.1Hz, 2H), 7.34(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.42(d, J=8.1Hz, 2H), 7.68(d, J=8.4Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr)1734, 1609, 1520, 1481, 1365, 1236, 1177, 1151, 1119, 1079, 970, 876, 797cm −1   
               
               
                 I-537 
                 m.p. 227–229° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.73(s, 3H), 3.16(s, 3H), 3.21(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 5.26(s, 2H), 6.83(s, 1H), 7.11(d, J=12.3Hz, 2H), 7.32(s, 1H), 
               
               
                   
                 7.37(d, J=12.3Hz, 2H), 7.41(s, 1H), 7.57(d, J=12.3Hz, 1H), 7.66(d, J=12.3Hz, 2H), 8.13(d, J=12.3Hz, 2H) 
               
               
                   
                 IR(KBr)3430, 1694, 1612, 1519, 1481, 1365, 1177, 1151, 1079, 875, 798cm −1   
               
               
                 I-538 
                 m.p. 149–151° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.66(s, 3H), 3.13(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.68(s, 2H), 3.77(s, 3H), 5.17(s, 2H), 6.84(s, 1H), 7.13(d, J=8.4Hz, 
               
               
                   
                 1H), 7.30–7.55(m, 4H), 7.38(d, J=8.4Hz, 2H), 7.67(d, J=8.4Hz, 2H), 7.67(m, 2H) 
               
               
                   
                 IR(KBr)3423, 1716, 1610, 1519, 1481, 1365, 1235, 1177, 1151, 1119, 1080, 876, 798cm −1   
               
               
                 I-539 
                 m.p. 144–146° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.32(s, 3H), 2.69(s, 3H), 3.14(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.18(s, 2H), 6.84(s, 1H), 7.14(d, J=8.7Hz, 
               
               
                   
                 2H), 7.15(d, J=8.4Hz, 1H), 7.34(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.48(d, J=8.7Hz, 2H), 7.67(d, J=8.4Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr)1760, 1519, 1481, 1365, 1177, 1151, 1119, 1079, 876, 797cm −1   
               
               
                 I-540 
                 m.p. 228–231° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.81(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.30(s, 2H), 6.85(s, 1H), 7.11(d, J=8.4Hz, 1H), 7.35(dd, 
               
               
                   
                 J=2.1, 8.4Hz, 1H), 7.39(d, J=8.4Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.67(d, J=8.4Hz, 2H), 7.69(d, J=8.7Hz, 2H), 8.28(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)1608, 1521, 1481, 1361, 1179, 1148, 1080, 880, 799cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 108 
               
               
                   
               
             
            
               
                 I-541 
                 m.p. 153–156° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.53(s, 9H), 2.69(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 7.10(dd, J=7.5, 7.5Hz, 
               
               
                   
                 1H), 7.17(d, J=7.5Hz, 1H), 7.23(d, J=8.4Hz, 1H), 7.26(dd, J=7.5, 7.5Hz, 1H), 7.33(d, J=7.5Hz, 1H), 7.37(dd, J=2.1, 8.4Hz, 1H), 7.38 
               
               
                   
                 (d, J=8.4Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.67(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3405, 1724, 1519, 1480, 1366, 1236, 1177, 1153, 1080, 970, 875, 798cm −1   
               
               
                 I-542 
                 m.p. 178–182° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.70(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.14(s, 2H), 6.76(m, 2H), 6.84(s, 1H), 7.19(m, 2H), 7.26 
               
               
                   
                 (d, J=8.7Hz, 1H), 7.37(d, J=2.7Hz, 1H), 7.36(dd, J=2.7, 8.7Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3448, 1627, 1608, 1519, 1497, 1364, 1177, 1151, 1079, 971, 876, 798cm −1   
               
               
                 I-543 
                 m.p. 187–189° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 3.39(s, 3H), 3.45(s, 3H), 5.11–5.14(m, 3H), 5.89(s, 1H), 6.33(s, 1H), 6.88–6.94(m, 2H), 7.20–7.36(m, 6H), 
               
               
                   
                 7.43(d, J=2.1Hz, 1H), 7.76(d, J=0.6Hz, 1H) 
               
               
                   
                 IR(KBr)3414, 2942, 1613, 1534, 1469, 1355, 1266, 1172, 1092, 1030cm −1   
               
               
                 I-544 
                 m.p. 207–215° C.(dec.) 
               
               
                   
                   1 HNMR(d6-DMSO) δ 2.37(s, 3H), 3.67(brs, 2H), 4.56(brs, 2H), 4.90(s, 2H), 6.14–6.20(m, 2H), 6.86(d, J=8.7Hz, 2H), 7.11–7.22(m, 4H), 
               
               
                   
                 7.42(d, J=8.7Hz, 2H), 7.52(s, 1H), 8.94(s, 1H), 9.47(s, 1H) 
               
               
                   
                 IR(KBr)3388, 3301, 2932, 1612, 1591, 1521, 1458, 1413, 1288, 1030cm −1   
               
               
                 I-545 
                 m.p. 108–110° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.74(s, 3H), 2.49–2.59(m, 2H), 3.03(s, 3H), 3.20(s, 3H), 3.56(s, 3H), 3.75(s, 3H), 4.06(t, J=6.6Hz, 2H), 4.93 
               
               
                   
                 (s, 2H), 5.22(m, 1H), 6.66(s, 1H), 7.04(d, J=8.7Hz, 1H), 7.09–7.17(m, 2H), 7.37(dd, J=2.1, 8.7Hz, 1H), 7.44(d, J=2.1Hz, 1H), 7.51–7.58 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(KBr)3434, 2933, 1604, 1521, 1473, 1383, 1360, 1278, 1160, 1121, 1084, 1017cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 109 
               
               
                   
               
             
            
               
                 I-546 
                 m.p. 109–110° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.75(s, 3H), 2.48–2.58(m, 2H), 4.07(t, J=6.6Hz, 2H), 5.22(m, 1H), 5.69(s, 1H), 5.87(s, 1H), 6.44(s, 1H), 
               
               
                   
                 6.93–6.95(m, 2H), 7.04–7.06(m, 1H), 7.10–7.18(m, 2H), 7.58–7.64(m, 2H) 
               
               
                   
                 IR(KBr)3411, 2932, 1608, 1587, 1522, 1491, 1226, 1111, 1074, 1017cm −1   
               
               
                 I-547 
                 m.p. 141–142° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.03(s, 3H), 3.57(s, 3H), 3.75(s, 3H), 4.90(s, 2H), 5.16(s, 2H), 5.65(brs, 1H), 6.66(s, 1H), 6.92(dd, J=1.8, 8.4Hz, 1H), 
               
               
                   
                 6.99(d, J=8.4Hz, 1H), 7.06(d, J=1.8Hz, 1H), 7.10–7.17(m, 2H), 7.35–7.47(m, 5H), 7.52–7.59(m, 2H) 
               
               
                   
                 IR(KBr)3529, 3439, 2932, 1601, 1518, 1477, 1461, 1380, 1251, 1224, 1157, 1113, 1094, 1076cm −1   
               
               
                 I-548 
                 m.p. 133–136° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.98(s, 3H), 3.12(s, 3H), 3.56(s, 3H), 3.75(s, 3H), 4.94(s, 2H), 5.18(s, 2H), 6.67(s, 1H), 7.09–7.17(m, 3H), 7.34–7.49 
               
               
                   
                 (m, 7H), 7.51–7.58(m, 2H) 
               
               
                   
                 IR(KBr)3434, 2941, 1598, 1519, 1481, 1383, 1365, 1279, 1231, 1164, 1099, 1081cm −1   
               
               
                 I-549 
                 m.p. 161–162° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.10(s, 3H), 3.42(s, 3H), 3.76(s, 3H), 5.17(s, 2H), 6.05(s, 1H), 6.44(s, 1H), 7.11–7.20(m, 3H), 7.33–7.50(m, 7H), 7.52 
               
               
                   
                 (d, J=2.1Hz, 1H), 7.57–7.65(m, 2H) 
               
               
                   
                 IR(KBr)3488, 2938, 1613, 1523, 1486, 1290, 1223, 1107, 1071, 1012cm −1   
               
               
                 I-550 
                 m.p. 113–115° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.37(s, 3H), 2.98(s, 3H), 3.11(s, 3H), 3.56(s, 3H), 3.75(s, 3H), 4.93(s, 2H), 5.13(s, 2H), 6.66(s, 1H), 7.09–7.17(m, 3H), 
               
               
                   
                 7.18–7.23(m, 2H), 7.32–7.39(m, 3H), 7.45(d, J=1.8Hz, 1H), 7.51–7.58(m, 2H) 
               
               
                   
                 IR(KBr)3434, 2934, 1738, 1601, 1520, 1478, 1466, 1376, 1356, 1236, 1159, 1109, 1070, 1014cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 110 
               
               
                   
               
             
            
               
                 I-551 
                 m.p. 138–140° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 3.04(s, 3H), 3.57(s, 3H), 3.74(s, 3H), 4.90(s, 2H), 5.11(s, 2H), 5.63(s, 1H), 6.66(s, 1H), 6.91(dd, J=2.1, 8.4Hz, 
               
               
                   
                 1H), 6.99(d, J=8.4Hz, 1H), 7.05(d, J=1.8Hz, 1H), 7.08–7.17(m, 2H), 7.22(d, J=7.8Hz, 2H), 7.33(d, J=7.8Hz, 2H), 7.52–7.59(m, 2H) 
               
               
                   
                 IR(KBr)3446, 2934, 1601, 1518, 1476, 1461, 1379, 1252, 1224, 1158, 1092, 1011cm −1   
               
               
                 I-552 
                 m.p. 188–190° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 3.10(s, 3H), 3.42(s, 3H), 3.75(s, 3H), 5.12(s, 2H), 6.04(s, 1H), 6.43(s, 1H), 7.11–7.25(m, 5H), 7.35(d, J=7.8Hz, 
               
               
                   
                 2H), 7.42(dd, J=2.4, 8.7Hz, 1H), 7.51(d, J=2.4Hz, 1H), 7.57–7.65(m, 2H) 
               
               
                   
                 IR(KBr)3433, 2963, 1611, 1523, 1485, 1355, 1282, 1226, 1163, 1106, 1071cm −1   
               
               
                 I-553 
                 m.p. 149–150° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.13(s, 3H), 3.21(s, 3H), 5.20(s, 2H), 7.17(d, J=8.4Hz, 1H), 7.24(m, 1H), 7.36–7.54(m, 9H), 7.58(dd, J=1.2, 2.4Hz, 1H), 
               
               
                   
                 7.60–7.67(m, 2H) 
               
               
                   
                 IR(KBr)1524, 1485, 1354, 1292, 1263, 1181, 1150, 1114, 977, 869, 858, 850, 812, 796cm −1   
               
               
                 I-554 
                 m.p. 92–93° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.74(d, J=1.2Hz, 3H), 2.25(s, 3H), 2.28(s, 3H), 2.56(dt, J=6.6, 7.2Hz, 2H), 3.20(s, 3H), 3.21(s, 3H), 4.07 
               
               
                   
                 (t, J=7.2Hz, 2H), 5.22(m, 1H), 7.05(d, J=8.4Hz, 1H), 7.11(s, 1H), 7.13(s, 1H), 7.25(dd, J=2.1, 8.4Hz, 1H), 7.31–7.43(m, 5H) 
               
               
                   
                 IR(KBr) 1518, 1488, 1355, 1293, 1264, 1169, 1151, 1109, 970, 872, 818cm −1   
               
               
                 I-555 
                 m.p. 126–127° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 3.20(s, 3H), 3.23(s, 3H), 4.65(d, J=6.6Hz, 2H), 5.50(m, 1H), 7.10(d, J=8.7Hz, 1H), 7.18–7.27 
               
               
                   
                 (m, 2H), 7.36–7.43(m, 2H), 7.50(dd, J=1.5, 8.7Hz, 1H), 7.55(d, J=1.5Hz, 1H), 7.60–7.66(m, 2H) 
               
               
                   
                 IR(KBr)1527, 1489, 1359, 1295, 1266, 1177, 1153, 1118, 974, 894, 874cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 111 
               
               
                   
               
             
            
               
                 I-556 
                 m.p. 154–155° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.25(s, 3H), 2.28(s, 3H), 2.38(s, 3H), 3.11(s, 3H), 3.20(s, 3H), 5.13(s, 2H), 7.11(s, 1H), 7.14(s, 1H), 7.19–7.28(m, 4H), 
               
               
                   
                 7.31–7.43(m, 7H) 
               
               
                   
                 IR(KBr)1520, 1487, 1365, 1284, 1260, 1192, 1172, 1152, 1108, 967, 867, 809, 795cm −1   
               
               
                 I-557 
                 m.p. 112–113° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.76(s, 3H), 2.26(s, 3H), 2.27(s, 3H), 2.54(dt, J=7.2, 6.9Hz, 2H), 4.07(t, J=6.9Hz, 2H), 4.86(s, 1H), 5.23 
               
               
                   
                 (m, 1H), 5.71(s, 1H), 6.82(dd, J=2.1, 8.4Hz, 1H), 6.85–6.93(m, 3H), 6.96(d, J=2.1Hz, 1H), 7.10(s, 1H), 7.12(s, 1H), 7.22–7.27(m, 2H) 
               
               
                   
                 IR(KBr)3380, 1613, 1586, 1523, 1490, 1471, 1431, 1391, 1293, 1261, 1246, 1205, 1171, 1130, 836cm −1   
               
               
                 I-558 
                 m.p. 141–142° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.06(s, 1H), 5.52(m, 1H), 5.75(s, 1H), 6.89–6.97(m, 3H), 7.07(dt, J=8.4, 
               
               
                   
                 1.8Hz, 1H), 7.14–7.23(m, 3H), 7.44–7.51(m, 2H) 
               
               
                   
                 IR(KBr)3429, 1612, 1594, 1531, 1489, 1467, 1449, 1401, 1259, 1213, 1169, 1132, 835, 781cm −1   
               
               
                 I-559 
                 m.p. 179–180° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.26(s, 3H), 2.28(s, 3H), 2.39(s, 3H), 4.81(s, 1H), 5.11(s, 2H), 5.70(s, 1H), 6.83(dd, J=2.1, 8.4Hz, 1H), 6.86–6.91(m, 2H), 
               
               
                   
                 6.98(d, J=8.4Hz, 1H), 6.98(d, J=2.1Hz, 1H), 7.10(s, 1H), 7.12(s, 1H), 7.21–7.28(m, 4H), 7.32–7.38(m, 2H) 
               
               
                   
                 IR(KBr)3317, 1609, 1520, 1489, 1426, 1378, 1247, 1206, 1175, 1124, 1006, 792cm −1   
               
               
                 I-560 
                 foam 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.74(s, 3H), 3.75(s, 3H), 4.62(d, J=5.0Hz, 2H), 5.02(t, J=5.0Hz, 1H), 5.19(s, 2H), 6.94(s, 1H), 6.99(s, 1H), 7.06(d, 
               
               
                   
                 J=8.0Hz, 1H), 7.22(ddd, J=8.6, 2.0, 0.8Hz, 1H), 7.32–7.52(m, 8H), 7.57(d, J=2.4Hz, 1H), 9.91(brs, 1H) 
               
               
                   
                 IR(KBr)3257, 1525, 1491, 1464, 1453, 1382, 1207, 1035, 764, 737cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 112 
               
               
                   
               
             
            
               
                 I-561 
                 m.p. 147–148° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.27(s, 3H), 3.79(s, 3H), 3.82(s, 3H), 5.26(s, 2H), 6.92(s, 1H), 6.95(s, 1H), 7.13(d, J=8.7Hz, 1H), 7.35–7.50(m, 8H), 7.80 
               
               
                   
                 (dd, J=8.7, 2.7Hz, 1H), 8.05(d, J=2.7Hz, 1H), 10.62(s, 1H) 
               
               
                   
                 IR(KBr)1682, 1606, 1489, 1377, 1345, 1261, 1209, 1168, 1119, 1038, 871, 832cm −1   
               
               
                 I-562 
                 m.p. 189–191° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.53(s, 3H), 3.80(s, 3H), 3.80(s, 3H), 5.27(s, 2H), 7.05(s, 1H), 7.10(s, 1H), 7.25(d, J=8.7Hz, 1H), 7.30–7.59(m, 7H), 
               
               
                   
                 7.66(dd, J=11.7, 2.1Hz, 1H), 7.67(dd, J=8.7, 2.3Hz, 1H), 7.84(d, J=2.3Hz, 1H), 12.7(brs, 1H) 
               
               
                   
                 IR(KBr)3433, 1705, 1492, 1371, 1250, 1207, 1168, 1033, 868cm −1   
               
               
                 I-563 
                 m.p. 204–207° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.36(s, 9H), 3.20(s, 3H), 3.41(s, 3H), 3.74(s, 3H), 5.15(s, 2H), 5.65(s, 1H), 5.77(s, 1H), 6.80(s, 1H), 6.83(dd, J=8.4, 2.0Hz, 
               
               
                   
                 1H), 6.96(d, J=2.0Hz, 1H), 6.98(d, J=8.4Hz, 1H), 7.34–7.45(m, 7H), 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3408, 3337, 1692, 1498, 1474, 1466, 1347, 1251, 1150, 870, 855cm −1   
               
               
                 I-564 
                 m.p. 179–182° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.76(s, 3H), 3.76(s, 3H), 5.26(s, 2H), 6.99(s, 1H), 7.00(t, J=8.7Hz, 1H), 7.01(s, 1H), 7.22(ddd, J=8.7, 2.4Hz, J=1.2Hz, 
               
               
                   
                 1H), 7.24(d, J=8.9Hz, 1H), 7.32–7.54(m, 6H), 7.65(dd, J=8.9, 2.4Hz, 1H), 7.82(d, J=2.4Hz, 1H), 9.91(s, 1H), 12.6(brs, 1H) 
               
               
                   
                 IR(KBr)3422, 3277, 1726, 1526, 1491, 1416, 1396, 1284, 1210, 1031cm −1   
               
               
                 I-565 
                 m.p. 178–180° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.30(s, 3H), 3.43(s, 3H), 3.61(s, 3H), 4.31(s, 2H), 5.14(s, 2H), 6.25(s, 1H), 6.61(dd, J=8.4, 1.9Hz, 1H), 7.05(d, J=8.4Hz, 
               
               
                   
                 1H), 7.33–7.44(m, 6H), 7.50–7.54(m, 2H), 7.70(d, J=8.7Hz, 2H), 9.08(s, 1H) 
               
               
                   
                 IR(KBr)3435, 3378, 1593, 1518, 1481, 1360, 1245, 1147, 1119, 1010, 871cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 113 
               
               
                   
               
             
            
               
                 I-566 
                 foam 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.27(s, 3H), 3.59(s, 3H), 4.21(s, 2H), 5.13(s, 2H), 6.17(s, 1H), 6.60(dd, J=8.3, 1.4Hz, 1H), 6.70(d, J=1.4Hz, 1H), 6.82 
               
               
                   
                 (d, J=8.4Hz, 2H), 7.03(d, J=8.3Hz, 1H), 7.33–7.53(m, 7H), 9.07(brs, 1H), 9.45(brs, 1H) 
               
               
                   
                 IR(KBr)3390, 1609, 1592, 1522, 1484, 1247, 1227, 1119, 1011, 812cm −1   
               
               
                 I-567 
                 m.p. 146–148° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.64(s, 3H), 1.70(s, 3H), 2.44(q, J=6.9Hz, 2H), 3.53(s, 3H), 3.78(s, 3H), 3.80(s, 3H), 4.05(t, J=6.9Hz, 2H), 5.26(t, 
               
               
                   
                 J=6.9Hz, 2H), 7.05(s, 1H), 7.10(s, 1H), 7.19(d, J=8.4Hz, 1H), 7.50(dd, J=8.4, 2.0Hz, 1H), 7.57(t, J=8.3Hz, 1H), 7.65(ddd, J=8.3, 1.9, 0.9Hz, 
               
               
                   
                 1H), 7.66(dd, J=11.9, 1.9Hz, 1H), 7.79(d, J=2.0Hz, 1H), 12.5(brs, 1H) 
               
               
                   
                 IR(KBr)3434, 3299, 1727, 1489, 1375, 1341, 1209, 1172, 1033, 851, 824cm −1   
               
               
                 I-568 
                 m.p. 179–181° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.31(s, 9H), 3.11(s, 3H), 3.20(s, 3H), 3.39(s, 3H), 3.74(s, 3H), 5.16(s, 2H), 5.98(s, 1H), 6.79(s, 1H), 7.09(d, J=8.5Hz, 
               
               
                   
                 1H), 7.29(dd, J=8.5, 1.9Hz, 1H), 7.35–7.49(m, 8H), 7.66(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3404, 3341, 1690, 1517, 1465, 1369, 1348, 1174, 1151, 869, 814cm −1   
               
               
                 I-569 
                 m.p. 189–191° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.31(s, 3H), 3.33(s, 3H), 3.43(s, 3H), 3.64(s, 3H), 4.48(s, 2H), 5.25(s, 2H), 6.28(s, 1H), 7.24(dd, J=9.0, 2.0Hz, 1H), 
               
               
                   
                 7.24(d, J=2.0Hz, 1H), 7.34–7.46(m, 6H), 7.52–7.55(m, 2H), 7.70(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3490, 3392, 1596, 1518, 1483, 1364, 1150, 872, 813cm −1   
               
               
                 I-570 
                 m.p. 194–196° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.07(s, 3H), 3.22(s, 3H), 3.36(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 6.92(s, 1H), 7.13(d, J=8.6Hz, 1H), 7.25(dd, J=8.6, 2.1Hz, 
               
               
                   
                 1H), 7.29(d, J=2.1Hz, 1H), 7.36–7.47(m, 7H), 7.63(brs, 1H), 7.67(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3433, 3329, 1737, 1518, 1476, 1369, 1168, 1148, 878cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 114 
               
               
                   
               
             
            
               
                 I-571 
                 m.p. 184–186° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.31(s, 3H), 2.38(s, 3H), 3.12(s, 3H), 3.45(s, 3H), 3.58(s, 3H), 3.76(s, 3H), 5.14(s, 2H), 6.95(s, 1H), 7.11–7.23(m, 5H), 
               
               
                   
                 7.34–7.37(m, 4H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.66(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )2952, 1732, 1614, 1599, 1518, 1467, 1445, 1370, 1290, 1256, 1169, 1117, 1081, 1064, 1003, 973, 905, 827cm −1   
               
               
                 I-572 
                 m.p. 218–220° C.  1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 3.12(s, 3H), 3.44(s, 3H), 3.63(s, 3H), 3.76(s, 3H), 5.14(s, 2H), 6.80–6.83(m, 2H), 6.94(s, 
               
               
                   
                 1H), 7.14(d, J=8.7Hz, 1H), 7.21–7.23(m, 4H), 7.35–7.37(m, 2H), 7.56(dd, J=8.7, 2.4Hz, 1H), 7.66(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )3596, 2939, 1720, 1613, 1522, 1466, 1445, 1370, 1346, 1291, 1258, 1183, 1172, 1116, 1081, 1064, 1003, 973, 904, 866, 837cm −1   
               
               
                 I-573 
                 m.p. 197–199° C.  1 HNMR(CD 3 OD) δ 3.19(s, 3H), 3.43(s, 3H), 3.76(s, 3H), 5.25(s, 2H), 7.06–7.12(m, 3H), 7.32–7.43(m, 6H), 7.52–7.54 
               
               
                   
                 (m, 2H), 7.60(dd, J=8.4, 2.4Hz, 1H), 7.66(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(KBr)3421, 2941, 1738, 1708, 1643, 1519, 1472, 1354, 1297, 1259, 1228, 1171, 1119, 1081, 1063, 1001, 958, 920, 871, 826, 755, 697,  
               
               
                   
                 524cm −1   
               
               
                 I-574 
                 m.p. 151–153° C.  1 HNMR(CDCl 3 ) δ 2.39(s, 3H), 3.44(s, 3H), 3.64(s, 3H), 3.74(s, 3H), 5.12(s, 2H), 5.78(br, 2H), 6.78–6.81(m, 2H), 6.94(s, 
               
               
                   
                 1H), 6.99(d, J=8.4Hz, 1H), 7.15–7.25(m, 6H), 7.33–7.36(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3595, 3541, 2952, 1730, 1612, 1591, 1521, 1474, 1395, 1345, 1323, 1290, 1258, 1173, 1129, 1081, 1063, 1004, 901, 863, 836cm −1   
               
               
                 I-575 
                 m.p. 195–196° C. 
               
               
                   
                   1 HNMR(CD 3 OD) δ 2.34(s, 3H), 3.40(s, 3H), 3.72(s, 3H), 5.16(s, 2H), 6.75–6.78(m, 2H), 6.96(s, 1H), 7.02(s, 1H), 7.14–7.21(m, 6H), 7.36–7.39 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(KBr)3530, 3398, 2942, 1708, 1610, 1593, 1520, 1465, 1373, 1334, 1256, 1233, 1127, 1078, 1056, 996, 960, 864, 834, 791, 755, 690, 651, 
               
               
                   
                 605, 534cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 115 
               
               
                   
               
             
            
               
                 I-576 
                 m.p. 82–84° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.70(s, 3H), 1.75(s, 3H), 2.54–2.59(m, 2H), 3.24(s, 3H), 3.50(s, 3H), 3.77(s, 3H), 4.10(t, J=6.9Hz, 2H), 5.23(m, 1H), 7.07– 
               
               
                   
                 7.12 
               
               
                   
                 (m, 4H), 7.23–7.28(m, 2H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.63(d, J=2.4Hz, 1H), 9.99(s, 1H) 
               
               
                   
                 IR(CHCl 3 )2936, 1697, 1604, 1591, 1518, 1469, 1445, 1371, 1331, 1294, 1232, 1172, 1159, 1123, 1093, 1005, 964cm −1   
               
               
                 I-577 
                 m.p. 126–128° C. 
               
               
                   
                   1 HNMR(CD 3 OD) δ 1.70(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.53–2.61(m, 2H), 3.25(s, 3H), 3.44(s, 3H), 3.75(s, 3H), 4.13(t, J=6.3Hz, 2H), 5.29 
               
               
                   
                 (m, 1H), 7.04–7.11(m, 3H), 7.24(d, J=8.7Hz, 1H), 7.33–7.38(m, 2H), 7.58–7.65(m, 2H) 
               
               
                   
                 IR(KBr)3432, 2940, 2566, 1735, 1711, 1646, 1613, 1519, 1470, 1447, 1366, 1297, 1264, 1228, 1172, 1118, 1081, 1063, 1001, 962, 920, 898, 
               
               
                   
                 871, 828, 796, 695, 524cm −1   
               
               
                 I-578 
                 m.p. 202–204° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.13(s, 3H), 3.45(s, 3H), 3.61(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.95(s, 1H), 7.05–7.11(m, 2H), 7.14(d, J=8.7Hz, 1H), 7.30– 
               
               
                   
                 7.49 
               
               
                   
                 (m, 7H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.67(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )2952, 1731, 1603, 1519, 1472, 1445, 1371, 1345, 1291, 1172, 1159, 1117, 1081, 1064, 1004, 972, 960, 904cm −1   
               
               
                 I-579 
                 m.p. 197–199° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.71(s, 3H), 3.56, (s, 3H), 3.75(s, 3H), 5.18(s, 2H), 5.72, (s, 1H), 6.86(s, 1H), 7.00(d, J=8.4Hz, 1H), 7.12–7.18(m, 3H), 7.24 
               
               
                   
                 (d, J=2.1Hz, 1H), 7.38–7.46(m, 7H) 
               
               
                   
                 IR(CHCl 3 )3543, 2939, 1602, 1521, 1482, 1465, 1394, 1370, 1328, 1254, 1178, 1159, 1130, 1081, 1005, 964, 840, 816cm −1   
               
               
                 I-580 
                 m.p. 199–201° C. 
               
               
                   
                   1 HNMR(CD 3 OD) δ 3.40(s, 3H), 3.73(s, 6H), 5.22(s, 2H), 7.00(s, 1H), 7.03–7.11(m, 4H), 7.17(m, 1H), 7.31–7.41(m, 5H), 7.49–7.52(m, 2H) 
               
               
                   
                 IR(KBr)3527, 3434, 2940, 1701, 1591, 1518, 1465, 1380, 1335, 1320, 1291, 1270, 1222, 1161, 1130, 1078, 1056, 1002, 916, 868, 837, 747, 
               
               
                   
                 698, 633, 599, 526, 480cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 116 
               
               
                   
               
             
            
               
                 I-581 
                 m.p. 122–123° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.78(s, 3H), 1.82(s, 3H), 3.25(s, 3H), 3.50(s, 3H), 3.76(s, 3H), 4.66(d, J=6.9Hz, 2H), 5.52(m, 1H), 7.09–7.14(m, 4H), 
               
               
                   
                 7.23–7.27(m, 2H), 7.56(dd, J=8.7, 2.1Hz, 1H), 7.63(d, J=2.1Hz, 1H), 9.99(s, 1H) 
               
               
                   
                 IR(CHCl 3 )2938, 1679, 1604, 1591, 1517, 1469, 1445, 1371, 1331, 1292, 1172, 1159, 1122, 1092, 1004, 973cm −1   
               
               
                 I-582 
                 m.p. 158–159° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.69(s, 3H), 3.13(s, 3H), 3.57(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.13–7.18(m, 3H), 7.37–7.49(m, 7H), 7.56 
               
               
                   
                 (dd, J=9.0, 2.1Hz, 1H), 7.62(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )2939, 1603, 1521, 1482, 1464, 1294, 1253, 1177, 1119, 1082, 1003, 963, 876, 842cm −1   
               
               
                 I-583 
                 m.p. 145–147° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.68(s, 3H), 3.54(s, 3H), 3.56(s, 3H), 3.75(s, 3H), 5.21(s, 2H), 5.27(s, 2H), 6.85(s, 1H), 7.00(d, J=8.7Hz, 1H), 7.13–7.23 
               
               
                   
                 (m, 3H), 7.33–7.49(m, 8H) 
               
               
                   
                 IR(CHCl 3 )2938, 1731, 1603, 1520, 1482, 1370, 1249, 1178, 1158, 1134, 1081, 1004, 961, 840, 815cm −1   
               
               
                 I-584 
                 m.p. 160–162° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.47(s, 3H), 3.74(s, 3H), 5.18(s, 2H), 5.72(s, 1H), 6.00(s, 1H), 6.46(s, 1H), 7.01(d, J=8.4Hz, 1H), 7.10–7.19(m, 3H), 7.27 
               
               
                   
                 (d, J=2.1Hz, 1H), 7.36–7.48(m, 7H) 
               
               
                   
                 IR(CHCl 3 )3540, 2938, 1603, 1568, 1522, 1490, 1464, 1416, 1396, 1325, 1263, 1158, 1111, 1072, 1002, 838cm −1   
               
               
                 I-585 
                 m.p. 133–134° C. 
               
               
                   
                   1 HNMR(CD 3 OD) δ 1.80(d, J=0.9Hz, 3H), 1.82(d, J=0.9Hz, 3H), 3.26(s, 3H), 3.44(s, 3H), 3.76(s, 3H), 4.71(d, J=6.9Hz, 2H), 5.55(m, 1H), 
               
               
                   
                 7.06–7.12(m, 3H), 7.26(d, J=8.7Hz, 1H), 7.34–7.36(m, 2H), 7.58–7.63(m, 2H) 
               
               
                   
                 IR(KBr)3422, 2939, 1736, 1702, 1603, 1519, 1472, 1368, 1293, 1228, 1187, 1173, 1117, 1081, 1061, 1003, 975, 961, 920, 827, 759, 701, 
               
               
                   
                 523cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 117 
               
               
                   
               
             
            
               
                 I-586 
                 m.p. 152–153° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.55–2.57(m, 2H), 3.23(s, 3H), 3.44(s, 3H), 3.60(s, 3H), 3.77(s, 3H), 4.09(t, J=6.6Hz, 
               
               
                   
                 2H), 5.22(m, 1H), 6.95(s, 1H), 7.05–7.11(m, 3H), 7.30–7.35(m, 2H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.64(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )2938, 1731, 1601, 1519, 1469, 1445, 1370, 1345, 1291, 1172, 1159, 1117, 1081, 1064, 1004, 973, 904, 864, 840cm −1   
               
               
                 I-587 
                 m.p. 132–133° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.44(s, 3H), 3.61(s, 3H), 3.75(s, 3H), 5.18(s, 2H), 5.71(s, 1H), 6.95(s, 1H), 6.99–7.10(m, 3H), 7.17(dd, J=8.4, 2.1Hz, 1H), 
               
               
                   
                 7.25–7.47(m, 8H) 
               
               
                   
                 IR(CHCl 3 )3542, 2952, 2938, 1731, 1597, 1519, 1474, 1392, 1345, 1321, 1290, 1266, 1159, 1130, 1080, 1063, 1000, 900, 862, 839cm −1   
               
               
                 I-588 
                 m.p. 92–94° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(d, J=0.6Hz, 3H), 1.76(d, J=1.2Hz, 3H), 2.51–2.58(m, 2H), 3.45(s, 3H), 3.75(s, 3H), 4.09(t, J=6.9Hz, 2H), 5.23 
               
               
                   
                 (m, 1H), 5.70(br, 1H), 6.92(d, J=8.4Hz, 1H), 6.97(s, 1H), 7.05–7.10(m, 2H), 7.16(dd, J=8.4, 2.1Hz, 1H), 7.23(d, J=2.1Hz, 1H), 7.33–7.38 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(KBr)3534, 3432, 2936, 1713, 1597, 1519, 1473, 1377, 1322, 1260, 1231, 1158, 1130, 1081, 1063, 1004, 961, 919, 837, 808, 791, 754, 705, 
               
               
                   
                 521cm −1   
               
               
                 I-589 
                 m.p. 120–122° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.76(s, 3H), 2.51–2.58(m, 2H), 3.44(s, 3H), 3.61(s, 3H), 3.75(s, 3H), 4.09(t, J=6.6Hz, 2H), 5.23(m, 1H), 5.73 
               
               
                   
                 (s, 1H), 6.92(d, J=8.4Hz, 1H), 6.96(s, 1H), 7.04–7.10(m, 2H), 7.16(dd, J=8.1, 1.8Hz, 1H), 7.23(d, J=1.8Hz, 1H), 7.31–7.36(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3541, 2937, 1731, 1598, 1519, 1471, 1391, 1345, 1323, 1290, 1265, 1159, 1130, 1080, 1063, 1005, 839cm −1   
               
               
                 I-590 
                 m.p. 154–156° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 3.24(s, 3H), 3.45(s, 3H), 3.61(s, 3H), 3.76(s, 3H), 4.64(d, J=7.2Hz, 2H), 5.51(m, 1H), 6.95(s, 
               
               
                   
                 1H), 7.05–7.11(m, 3H), 7.31–7.35(m, 2H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.64(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(CHCl 3 )2938, 1731, 1602, 1519, 1472, 1445, 1370, 1345, 1290, 1186, 1116, 1080, 1064, 1003, 973, 904, 840cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 118 
               
               
                   
               
             
            
               
                 I-591 
                 m.p. 181–182° C. 
               
               
                   
                   1 HNMR(CD 3 OD) δ 1.77(s, 3H), 1.80(d, J=0.9Hz, 3H), 3.42(s, 3H), 3.74(s, 3H), 4.65(d, J=6.9Hz, 2H), 5.55(m, 1H), 6.99–7.11(m, 5H), 7.15 
               
               
                   
                 (d, J=2.1Hz, 1H), 7.32–7.36(m, 2H) 
               
               
                   
                 IR(KBr)3529, 3424, 2937, 1714, 1598, 1519, 1473, 1417, 1372, 1336, 1321, 1258, 1235, 1157, 1129, 1080, 1062, 1004, 989, 917, 854, 839, 
               
               
                   
                 807, 791, 752, 703cm −1   
               
               
                 I-592 
                 m.p. 109–110° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.78(s, 3H), 1.83(s, 3H), 3.44(s, 3H), 3.61(s, 3H), 3.75(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.53(m, 1H), 5.72(s, 1H), 6.94(d, 
               
               
                   
                 J=8.1Hz, 1H), 6.96(s, 1H), 7.04–7.10(m, 2H), 7.16(dd, J=8.4, 2.1Hz, 1H), 7.23(d, J=2.1Hz, 1H), 7.31–7.36(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3538, 2938, 1731, 1598, 1519, 1473, 1391, 1345, 1290, 1264, 1159, 1129, 1080, 1063, 1004, 900, 862, 839cm −1   
               
               
                 I-593 
                 m.p. 185–187° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.78(s, 3H), 3.80(s, 3H), 4.82(s, 1H), 6.61(m, 1H), 6.88–6.93(m, 2H), 6.96(s, 1H), 7.04(s, 1H), 7.23–7.25(m, 1H), 7.45 
               
               
                   
                 (d, J=0.9Hz, 1H), 7.48–7.53(m, 2H), 7.83(d, J=0.9Hz, 1H), 8.18(brs, 1H) 
               
               
                   
                 IR(KBr)3600–3200(br), 1611, 1523, 1496, 1464, 1447, 1388, 1268, 1239, 1202, 1046, 1025cm −1   
               
               
                 I-594 
                 m.p. 188–189° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.19(s, 3H), 3.79(s, 3H), 3.81(s, 3H), 6.61–6.62(m, 1H), 6.96(s, 1H), 7.06(s, 1H), 7.24–7.26(m, 1H), 7.33–7.37(m, 2H), 
               
               
                   
                 7.45(brs, 2H), 7.64–7.68(m, 2H), 7.84(d, J=0.9Hz, 1H), 8.21(brs, 1H) 
               
               
                   
                 IR(KBr)3600–3200(br), 1518, 1494, 1465, 1419, 1389, 1351, 1331, 1314, 1213, 1177, 1145, 1051, 1027cm −1   
               
               
                 I-595 
                 m.p. 98–101° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.78(s, 3H), 1.82(s, 3H), 1.85(s, 3H), 3.78(s, 3H), 3.79(s, 3H), 4.56(d, J=6.9Hz, 2H), 4.72(d, J=6.9Hz, 2H), 
               
               
                   
                 5.39–5.44(m, 1H), 5.52–5.57(m, 1H), 6.53(d, J=3.0Hz, 1H), 6.97–7.03(m, 4H), 7.12(d, J=3.3Hz, 1H), 7.38(d, J=8.4Hz, 1H), 7.45(dd, 
               
               
                   
                 J=1.8, 8.7Hz, 1H), 7.52–7.57(m, 2H), 7.81(d, J=1.5Hz, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1606, 1498, 1476, 1463, 1382, 1262, 1241, 1206, 1177, 1052, 1030cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 119 
               
               
                   
               
             
            
               
                 I-596 
                 m.p. 207–210° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.19(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.50(s, 2H), 6.65(d, J=3.0Hz, 1H), 6.81(d, J=7.8Hz, 1H), 6.96(s, 1H), 7.05(s, 1H), 
               
               
                   
                 7.19–7.22(m, 1H), 7.25–7.45(m, 6H), 7.54–7.60(m, 1H), 7.64–7.69(m, 2H), 7.86(brs, 1H), 8.61–8.64(m, 1H) 
               
               
                   
                 IR(KBr)3600–3200(br), 1496, 1478, 1364, 1347, 1210, 1176, 1155, 1052, 1028cm −1   
               
               
                 I-597 
                 m.p. 222–224° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.36(s, 3H), 2.53(s, 3H), 3.77(s, 3H), 3.78(s, 3H), 6.69(dd, J=0.9, 4.2Hz, 1H), 6.95(s, 1H), 6.96(s, 1H), 7.23–7.28(m, 2H), 
               
               
                   
                 7.31–7.35(m, 2H), 7.51–7.54(m, 3H), 7.59(d, J=3.3Hz, 1H), 7.73(d, J=1.2Hz, 1H), 7.80–7.84(m, 2H), 8.03(d, J=1.2Hz, 1H) 
               
               
                   
                 IR(KBr)3600–3200(br), 1509, 1487, 1464, 1444, 1366, 1208, 1172, 1129, 1092, 1049, 1028cm −1   
               
               
                 I-598 
                 m.p. 126–127° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.71(d, J=0.9Hz, 3H), 2.56(dt, J=6.6, 6.9Hz, 2H), 3.20(s, 3H), 3.22(s, 3H), 4.08(t, J=6.9Hz, 2H), 5.21(m, 
               
               
                   
                 1H), 7.08(d, J=8.4Hz, 1H), 7.18–7.27(m, 2H), 7.36–7.43(m, 2H), 7.50(dd, J=1.8, 8.4Hz, 1H), 7.56(d, J=1.8Hz, 1H), 7.59–7.66(m, 2H) 
               
               
                   
                 IR(KBr)1528, 1488, 1469, 1395, 1362, 1342, 1297, 1265, 1201, 1176, 1152, 1116, 968, 890, 872, 818cm −1   
               
               
                 I-599 
                 m.p. 169–170° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.32(s, 3H), 3.37(s, 3H), 3.45(s, 3H), 5.23(s, 2H), 7.23(d, J=7.8Hz, 2H), 7.37–7.44(m, 3H), 7.47–7.53(m, 2H), 7.56–7.66 
               
               
                   
                 (m, 4H), 7.75(d, J=7.5Hz, 2H) 
               
               
                   
                 IR(KBr)1525, 1485, 1366, 1355, 1291, 1262, 1181, 1150, 1116, 969, 869, 811cm −1   
               
               
                 I-600 
                 m.p. 123–124° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.75(d, J=0.9Hz, 3H), 2.53(dt, J=7.2, 6.9Hz, 2H), 4.07(t, J=6.9Hz, 2H), 4.91(s, 1H), 5.22(m, 1H), 5.72(s, 
               
               
                   
                 1H), 6.89–6.95(m, 2H), 7.07(m, 1H), 7.14–7.22(m, 4H), 7.44–7.51(m, 2H) 
               
               
                   
                 IR(KBr)3448, 1612, 1593, 1530, 1489, 1475, 1401, 1262, 1212, 1181, 1169, 1132, 839, 779cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 120 
               
               
                   
               
             
            
               
                 I-601 
                 m.p. 184–185° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.31(s, 3H), 5.13(s, 2H), 6.85–6.91(m, 2H), 6.97(m, 1H), 7.07(d, J=8.4Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.20(d, J=8.1Hz, 
               
               
                   
                 2H), 7.32–7.48(m, 6H) 
               
               
                   
                 IR(KBr)3290, 1614, 1529, 1491, 1459, 1449, 1405, 1380, 1267, 1254, 1167, 1132, 783cm −1   
               
               
                 I-602 
                 m.p. 141–142° C. 
               
               
                   
                   1 HNMR(CDCl 3  ) δ 1.77(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.78(s, 3H), 4.56(d, J=6.8Hz, 2H), 5.54(t, J=6.6Hz, 1H), 6.96–7.26(m, 7H), 7.61 
               
               
                   
                 (dd, J=5.2, 8.6Hz, 2H), 9.88(s, 1H) 
               
               
                   
                 IR(KBr)3433, 2955, 2922, 2865, 2833, 1687, 1604, 1515, 1462, 1288, 1258, 1232, 1180, 1160, 1070, 998, 845cm −1   
               
               
                 I-603 
                 m.p. 169–170° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 3.46(s, 3H), 3.77(s, 3H), 5.07(s, 2H), 7.02–7.38(m, 7H), 7.61(dd, J=5.4, 8.8Hz, 2H), 9.89(brs, 1H) 
               
               
                   
                 IR(KBr)3433, 2936, 2840, 1698, 1517, 1462, 1251, 1233, 1067, 999, 837cm −1   
               
               
                 I-604 
                 m.p. 120–121° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.74(s, 3H), 2.50–2.57(m, 2H), 3.46(s, 3H), 3.77(s, 3H), 3.98(t, J=7.0Hz, 2H), 5.24(t, J=7.0Hz, 1H), 6.94–7.26 
               
               
                   
                 (m, 7H), 7.61(dd, J=5.4, 8.8Hz, 2H), 9.88(brs, 1H) 
               
               
                   
                 IR(KBr)3435, 2960, 2937, 2876, 1698, 1605, 1516, 1464, 1441, 1379, 1296, 1272, 1233, 1221, 1161, 1073, 1024, 845, 807cm −1   
               
               
                 I-605 
                 m.p. 151–152° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.34(s, 6H), 3.07–3.15(m, 1H), 3.32(s, 3H), 3.67(s, 3H), 3.97–4.08(m, 1H), 4.28–4.34(m, 1H), 6.48(s, 1H), 7.00(d, 
               
               
                   
                 J=7.8Hz, 2H), 7.22–7.35(m, 4H), 7.66(dd, J=3.2, 6.0Hz, 2H), 8.72(brs, 1H) 
               
               
                   
                 IR(KBr)3460, 2960, 2935, 1607, 1521, 1488, 1456, 1392, 1244, 1226, 1160, 1122, 1073, 818cm −1   
               
               
                 I-606 
                 m.p. 164–165° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.32(s, 3H), 3.31(s, 3H), 3.66(s, 3H), 5.08(s, 2H), 6.46(s, 1H), 6.99(d, J=5.8Hz, 2H), 7.20–7.38(m, 4H), 7.65(dd, J=3.6, 
               
               
                   
                 6.2Hz, 2H), 8.69(brs, 1H) 
               
               
                   
                 IR(KBr)3367, 2940, 1605, 1519, 1484, 1466, 1449, 1390, 1229, 1181, 1158, 1059, 1006, 987, 831, 817cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 121 
               
               
                   
               
             
            
               
                 I-607 
                 m.p. 103–104° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.37(s, 6H), 2.47–2.59(m, 2H), 3.31(s, 3H), 3.66(s, 3H), 3.94–4.05(m, 1H), 4.26–4.34(m, 1H), 6.44(s, 1H), 7.02(d, 
               
               
                   
                 J=7.6Hz, 2H), 7.18–7.35(m, 4H), 7.64(dd, J=3.4, 6.6Hz, 2H), 8.77(brs, 1H) 
               
               
                   
                 IR(KBr)3400, 2993, 2961, 2930, 1607, 1522, 1486, 1471, 1454, 1393, 1226, 1123, 1072, 835, 819cm −1   
               
               
                 I-608 
                 m.p. 157–158° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.73(s, 3H), 1.77(s, 3H), 3.31(s, 3H), 3.72(s, 3H), 4.54(d, J=6.9Hz, 2H), 5.47(t, J=7.2Hz, 1H), 6.93(d, J=8.7Hz, 2H), 
               
               
                   
                 7.05(s, 1H), 7.19(d, J=9.0Hz, 2H), 7.30–7.36(m, 2H), 7.70(dd, J=5.4, 8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3406, 2936, 1712, 1608, 1519, 1472, 1444, 1375, 1235, 839cm −1   
               
               
                 I-609 
                 m.p. 215–216° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.34(s, 3H), 3.33(s, 3H), 3.74(s, 3H), 5.09(s, 2H), 7.00–7.07(m, 3H)7.22–7.39(m, 8H), 7.73(dd, J=5.6, 8.0Hz, 2H) 
               
               
                   
                 IR(KBr)3494, 3289, 2938, 1745, 1698, 1520, 1471, 1461, 1378, 1296, 1239, 1183, 1159, 829cm −1   
               
               
                 I-610 
                 m.p. 169–170° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.64(s, 3H), 1.71(s, 3H), 2.41–2.46(m, 2H), 3.32(s, 3H), 3.73(s, 3H), 3.97(t, J=6.6Hz, 2H), 5.23(t, J=7.2Hz, 1H), 
               
               
                   
                 6.93(d, J=8.1Hz, 2H), 7.05(s, 1H), 7.20(d, J=7.2Hz, 2H), 7.30–7.36(m, 2H), 7.70(dd, J=4.5, 7.5Hz, 2H) 
               
               
                   
                 IR(KBr)3424, 2933, 1701, 1609, 1519, 1471, 1379, 1294, 1248, 1061, 839cm −1   
               
               
                 I-611 
                 m.p. 167–168° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.75(s, 3H), 1.82(s, 3H), 2.35(s, 6H), 2.45(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.70(s, 3H), 4.35(d, J=6.9Hz, 2H), 5.60(t, J= 
               
               
                   
                 7.2Hz, 1H), 6.84(s, 1H), 7.08(s, 2H), 7.38(d, J=8.7Hz, 2H), 7.70(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3433, 2932, 1509, 1475, 1376, 1359, 1232, 1177, 1152, 1085, 966, 874, 797cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 122 
               
               
                   
               
             
            
               
                 I-612 
                 m.p. 175–176° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.35(s, 6H), 2.39(s, 3H), 2.49(s, 3H), 3.21(s, 3H), 3.56(s, 3h), 3.79(s, 3H), 4.83(s, 2H), 6.84(s, 1H), 7.10(s, 2H), 7.22(d, 
               
               
                   
                 J=7.5Hz, 2H), 7.38(d, J=8.4Hz, 4H), 7.70(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3434, 2936, 1510, 1475, 1363, 1229, 1176, 1152, 1083, 964, 871, 803cm −1   
               
               
                 I-613 
                 m.p. 138–139° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.75(s, 3H), 2.33(s, 6H), 2.52–2.55(m, 2H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 3.79(t, J=6.9Hz, 2H), 5.27 
               
               
                   
                 (t, J=6.6Hz, 1H), 6.83(s, 3H), 7.08(s, 6H), 7.38(d, J=8.7Hz, 2H), 7.70(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3432, 2939, 1509, 1476, 1448, 1362, 1237, 1172, 1155, 1103, 1081, 963, 873, 800cm −1   
               
               
                 I-614 
                 m.p. 89–90° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.74(s, 3H), 1.77(s, 3h), 3.36(s, 3H), 3.67(s, 3H), 4.22(d, J=3.0Hz, 2H), 4.56(d, J=6.3Hz, 2H), 5.48(t, J=5.7Hz, 1H), 
               
               
                   
                 6.93–6.96(m, 3H), 7.11(d, J=8.7Hz, 2H), 7.28–7.34(m, 2H), 7.68(dd, J=6.0, 8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3528, 3418, 2935, 1608, 1518, 1472, 1233, 1004, 836cm −1   
               
               
                 I-615 
                 m.p. 89–90° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.33(s, 3H), 3.36(s, 3H), 3.67(s, 3H), 4.22(d, J=3.9Hz, 2H), 4.59(t, J=4.2Hz, 1H), 5.09(s, 2H), 6.94(s, 1H), 7.02(d, 
               
               
                   
                 J=8.4Hz, 2H), 7.22(d, J=8.4Hz, 4H), 7.28–7.39(m, 4H), 7.68(dd, J=5.7, 8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3485, 2931, 1517, 1473, 1460, 1383, 1243, 1225, 1079, 1014, 1001, 834, 798cm −1   
               
               
                 I-616 
                 oil 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.75(s, 3H), 1.78(s, 3H), 2.47–2.52(m, 2H), 3.39(s, 3H), 3.71(s, 3H), 4.25(d, J=3.3Hz, 2H), 4.49(d, J=6.3Hz, 2H), 
               
               
                   
                 5.46(t, J=5.7Hz, 1H), 6.91–6.95(m, 3H), 7.13(d, J=8.4Hz, 2H), 7.24–7.32(m, 2H), 7.67(dd, J=5.7, 8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3528, 3419, 2935, 1608, 1518, 1472, 1383, 1232, 1004, 837cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 123 
               
               
                   
               
             
            
               
                 I-617 
                 m.p. 138–139° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.70(s, 3H), 1.77(s, 3H), 2.24(s, 6H), 3.30(s, 3H), 3.64(s, 3H), 4.31(d, J=6.9Hz, 2H), 5.56(t, J=6.6Hz, 1H), 6.39(s, 
               
               
                   
                 1H), 6.84(d, J=8.4Hz, 2H), 6.91(s, 2H), 7.44(d, J=8.4Hz, 2H), 8.50(s, 1H), 9.50(s, 1H) 
               
               
                   
                 IR(KBr)3400, 2966, 2934, 1609, 1519, 1465, 1444, 1389, 1362, 1269, 1228, 1211, 1194, 1171, 1118, 1089, 1027, 953cm −1   
               
               
                 I-618 
                 m.p. 122–123° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.29(s, 6H), 2.37(s, 3H), 3.30(s, 3H), 3.67(s, 3H), 4.81(s, 2H), 6.43(s, 1H), 6.86(d, J=7.5Hz, 2H), 6.97(s, 2H), 7.27 
               
               
                   
                 (d, J=6.9Hz, 2H), 7.42–7.48(m, 2H), 8.54(s, 1H), 9.52(s, 1H) 
               
               
                   
                 IR(KBr)3483, 3423, 2931, 1735, 1709, 1612, 1520, 1477, 1454, 1411, 1395, 1362, 1224, 1176, 1117, 1089, 1028cm −1   
               
               
                 I-619 
                 m.p. 81–82° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.70(s, 3H), 1.76(s, 3H), 2.18–2.30(m, 2H), 2.27(s, 6H), 3.34(s, 3H), 3.68(s, 3H), 3.80(t, J=4.5Hz, 2H), 5.34(t, J= 
               
               
                   
                 5.1Hz, 1H), 6.43(s, 1H), 6.88(d, J=7.5Hz, 2H), 6.94(s, 6H), 7.46–7.50(m, 2H), 8.53(s, 1H), 9.54(s, 1H) 
               
               
                   
                 IR(KBr)3410, 2930, 1612, 1521, 1479, 1454, 1395, 1361, 1265, 1227, 1174, 1117, 1090, 1028, 825cm −1   
               
               
                 I-620 
                 m.p. 161–162° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.32(s, 9H), 2.38(s, 3H), 3.10(s, 3H), 3.20(s, 3H), 3.39(s, 3H), 3.74(s, 3H), 5.12(s, 2H), 5.96(s, 1H), 6.79(s, 1H), 7.09 
               
               
                   
                 (d, J=8.4Hz, 1H), 7.21(d, J=7.8Hz, 2H), 7.28(dd, J=8.4, 1.8Hz, 1H), 7.33–7.38(m, 5H), 7.67(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3398, 1718, 1518, 1472, 1366, 1173, 1151, 877, 867, 813cm −1   
               
               
                 I-621 
                 m.p. 139–141° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.33(s, 9H), 1.68(s, 3H), 1.74(s, 3H), 2.54(q, J=6.9Hz, 2H), 3.19(s, 3H), 3.20(s, 3H), 3.39(s, 3H), 3.73(s, 3H), 4.05(t, J= 
               
               
                   
                 6.9Hz, 2H), 5.21(t, J=6.9Hz, 1H), 5.95(s, 1H), 6.79(s, 1H), 7.02(d, J=8.4Hz, 1H), 7.29(dd, J=8.4, 1.9Hz, 1H), 7.33(d, J=1.9Hz, 1H), 7.36 
               
               
                   
                 (d, J=8.7Hz, 2H), 7.66(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3416, 1720, 1519, 1469, 1365, 1237, 1152, 1117, 975, 872, 815cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 124 
               
               
                   
               
             
            
               
                 I-622 
                 m.p. 197–199° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.33(s, 3H), 3.31(s, 6H), 3.43(s, 3H), 3.64(s, 3H), 3.74(s, 3H), 4.47(s, 2H), 5.19(s, 2H), 6.28(s, 1H), 7.21–7.25(m, 4H), 
               
               
                   
                 7.35(d, J=8.7Hz, 1H), 7.40–7.44(m, 4H), 7.70(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3482, 3385, 1597, 1519, 1484, 1368, 1353, 1150, 872, 813cm −1   
               
               
                 I-623 
                 m.p. 99–101° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.32(s, 3H), 3.27(s, 3H), 3.59(s, 3H), 4.21(s, 2H), 5.08(s, 2H), 6.17(s, 1H), 6.58(dd, J=8.0, 1.8Hz, 1H), 6.69(d, J=1.8Hz, 
               
               
                   
                 1H), 6.82(d, J=8.7Hz, 2H), 7.01(d, J=8.0Hz, 1H), 7.21(d, J=7.8Hz, 2H), 7.39(d, J=7.8Hz, 2H), 7.41(d, J=8.7Hz, 2H), 9.02(brs, 1H), 
               
               
                   
                 9.45(brs, 1H) 
               
               
                   
                 IR(KBr)3390, 1609, 1592, 1521, 1484, 1246, 1227, 1117, 1011, 810cm −1   
               
               
                 I-624 
                 m.p. 215–217° C. 
               
               
                   
                   1 HNMR(CDCl 3  + CD 3 OD)d3.78(s, 3H), 3.79(s, 3H), 5.49(s, 2H), 6.64(dd, J=0.6, 2.7Hz, 1H), 6.79(d, J=8.1Hz, 1H), 6.90(d, J=8.7Hz, 2H), 
               
               
                   
                 6.96(s, 1H), 7.02(s, 1H), 7.19–7.32(m, 3H), 7.40–7.50(m, 3H), 7.56–7.60(m, 1H), 7.85(d, J=0.9Hz, 1H), 8.58–8.60(m, 1H) 
               
               
                   
                 IR(KBr)3600–2600(br), 1611, 1599, 1500, 1477, 1445, 1395, 1264, 1238, 1210, 1052, 1029, 1008cm −1   
               
               
                 I-625 
                 m.p. 213–214° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.36(s, 3H), 3.77(s, 6H), 6.70(dd, J=0.6, 3.6Hz, 1H), 6.93(s, 1H), 6.96(s, 1H), 7.08–7.16(m, 2H), 7.24–7.28(m, 2H), 
               
               
                   
                 7.51–7.60(m, 4H), 7.73(d, J=1.5Hz, 1H), 7.80–7.84(m, 2H), 8.03(d, J=9.0Hz, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1597, 1517, 1496, 1464, 1444, 1372, 1209, 1189, 1172, 1157, 1121, 1092, 1050, 1028cm −1   
               
               
                 I-626 
                   1 HNMR(CDCl 3  + CD 3 OD) δ 3.13(s, 3H), 3.81(s, 3H), 3.82(s, 3H), 5.19(s, 2H), 6.97(s, 1H), 6.99(s, 1H), 7.14(d, J=8.7Hz, 1H), 7.34–7.52 
               
               
                   
                 (m, 6H), 7.61(d, J=2.1Hz, 1H), 7.73(d, J=8.4Hz, 2H), 8.12(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3432, 1616, 1520, 1494, 1452, 1388, 1352, 1282, 1261, 1211, 1186, 1175, 1113, 1058, 1033cm −1   
               
               
                 I-627 
                   1 HNMR(CDCl 3 ) δ 3.81(s, 6H), 5.17(s, 2H), 6.99(s, 1H), 7.00(d, J=8.4Hz, 1H), 7.09(dd, J=8.4&amp; 1.8Hz, 1H), 7.23(d, J=1.8Hz, 1H), 
               
               
                   
                 7.33–7.50(m, 5H), 7.76(.d, J=8.4Hz, 2H), 8.10(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3551, 3520, 3399, 1615, 1587, 1576, 1521, 1488, 1455, 1383, 1268, 1245, 1208, 1126, 1055, 1034, 1003cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 125 
               
               
                   
               
             
            
               
                 I-628 
                   1 HNMR(CDCl 3 ) δ 3.05(s, 3H), 3.47(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 6.45(s, 1H), 6.94(dd, J=8.4&amp;1.8Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.06 
               
               
                   
                 (d, J=1.8Hz, 1H), 7.30(d, J=8.1Hz, 2H), 7.36–7.51(m, 5H), 7.63(d, J=8.1Hz, 2H) 
               
               
                   
                 IR(KBr)3525, 3472, 1609, 1588, 1522, 1487, 1455, 1407, 1321, 1286, 1242, 1148, 1115, 1071, 1013cm −1   
               
               
                 I-629 
                   1 HNMR(CDCl 3 ) δ 2.68(s, 3H), 3.07(s, 3H), 3.14(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.27–7.50 
               
               
                   
                 (m, 9H), 7.62(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3432, 1611, 1522, 1482, 1462, 1392, 1358, 1295, 1233, 1178, 1154, 1119, 1082, 1012cm −1   
               
               
                 I-630 
                   1 HNMR(CDCl 3 ) δ 2.88(s, 3H), 3.08(s, 3H), 3.28(s, 3H), 3.30(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 6.87(s, 1H), 7.32(d, J=8.4Hz, 2H), 
               
               
                   
                 7.43(d.d, J=8.4&amp;2.1Hz, 1H), 7.54–7.65(m, 4H) 
               
               
                   
                 IR(KBr)3432, 1612, 1519, 1481, 1367, 1332, 1232, 1177, 1154, 1077, 1011cm −1   
               
               
                 I-631 
                   1 HNMR(CDCl 3 ) δ 1.57(s, 3H), 169(s, 3H), 2.66(s, 3H), 2.97(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 4.31(d, J=7.2Hz, 2H), 
               
               
                   
                 5.19(s, 2H), 5.21–5.32(m, 1H), 6.86(s, 1H), 7.15(.d, J=8.7Hz, 1H), 7.30–7.52(m, 9H), 7.63(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 1609, 1520, 1481, 1365, 1338, 1294, 1270, 1233, 1178, 1153, 1118, 1078, 1015, 947cm −1   
               
               
                 I-632 
                   1 HNMR(CDCl 3 ) δ 1.45(s, 3H), 1.59(s, 3H), 1.66(s, 3H), 1.70(s, 3H), 2.97(s, 3H), 3.11(s, 3H), 3.64(s, 3H), 3.75(s, 3H), 4.28(d, J=8.4Hz, 
               
               
                   
                 2H), 4.32(d, J=8.4Hz, 2H), 5.18(s, 2H), 5.23(t, J=8.4Hz, 1H)), 5.29(t, J=8.4Hz, 1H), 6.70(s, 1H), 7.10(d, J=8.4Hz, 1H)7.30–7.51(m, 9H), 
               
               
                   
                 7.58(d, J=8.4Hz, 2H) 
               
               
                 I-633 
                   1 HNMR(CDCl 3 ) δ 1.58(s, 3H), 1.69(s, 3H), 2.97(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 433(d, J=7.5Hz, 2H), 5.16(s, 2H), 5.24–5.33(m, 1H), 
               
               
                   
                 5.69(s, 1H), 5.87(s, 1H), 6.47(s, 1H), 6.95(d.d, J=8.4&amp;2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.09(.d, J=2.1Hz, 1H), 7.31–7.50(m, 7H), 
               
               
                   
                 7.65(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3450, 1609, 1590, 1558, 1524, 1487, 1448, 1421, 1320, 1233, 1143, 1117, 1073, 1019cm −1   
               
               
                 I-634 
                   1 HNMR(CDCl 3 ) δ 1.57(s, 3H), 1.68(s, 3H), 2.66(s, 3H), 2.70(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 4.33(d, J=8.4Hz, 2H), 5.19(s, 
               
               
                   
                 2H), 5.26(t, J=8.4Hz), 6.86(s, 1H), 7.15(d, J=8.7Hz, 1H), 7.30–7.49(m, 9H), 7.63(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1615, 1517, 1480, 1372, 1337, 1233, 1213, 1178, 1154, 1076, 1014cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 126 
               
               
                   
               
             
            
               
                 I-635 
                   1 HNMR(CDCl 3 ) δ 1.58(s, 3H), 1.69(s, 3H), 2.82(s, 3H), 2.97(s, 3H), 3.29(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.33(d, J=7.2Hz, 2H), 5.27(t, 
               
               
                   
                 J=7.2Hz, 1H), 6.25(s, 1H), 6.86(s, 1H), 7.17(d, J=9.0Hz, 1H)), 7.23–7.32(m, 2H), 7.41(d, J=8.7Hz, 2H), 7.63(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3431, 1611, 1522, 1482, 1364, 1337, 1294, 1231, 1178, 1153, 1077, 1014cm −1   
               
               
                 I-636 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.09(s, 3H), 3.47(s, 3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.47–5.58(m, 1H), 5.71(s, 1H), 
               
               
                   
                 5.87(s, 1H), 6.45(s, 1H), 6.60(s, 1H), 6.89–7.01(m, 2H), 7.05(d, J=0.6Hz, 1H), 7.30(.d, J=8.7Hz, 2H), 7.65(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3448, 3265, 1612, 1585, 1521, 1487, 1330, 1287, 1243, 1225, 1152, 1112, 1069, 971cm −1   
               
               
                 I-637 
                   1 HNM z R(CDCl 3 ) δ 1.57(s, 3H), 1.69(s, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.70(s, 3H), 2.97(s, 3H), 3.24(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 4.32 
               
               
                   
                 (d, J=6.9Hz, 2H), 4.64(d, J=6.6Hz, 2H), 5.27(t, J=6.9Hz, 1H), 5.49(t, J=6.6Hz, 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.32–7.44(m, 4H), 
               
               
                   
                 7.63(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1609, 1520, 1481, 1365, 1339, 1292, 1270, 1236, 1178, 1153, 1118, 1078, 1015cm −1   
               
               
                 I-638 
                   1 HNMR(CDCl 3 ) δ 1.58(s, 3H), 1.69(s, 3H), 1.76(s, 3H), 1.82(s, 3H), 2.97(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.32(d, J=7.8Hz, 2H), 
               
               
                   
                 4.63(.d, J=7.8Hz, 2H), 5.23–5.33(m, 1H), 5.48–5.57(m, 1H), 5.69(s, 1H), 5.85(s, 1H), 6.46(s, 1H), 6.89–7.02(m, 2H), 7.05(d, J=1.8Hz, 
               
               
                   
                 1H), 7.40(d, J=8.7Hz, 2H), 7.65(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3450, 1609, 1588, 1557, 1525, 1487, 1445, 1327, 1248, 1148, 1114, 1072, 1015cm −1   
               
               
                 I-639 
                   1 HNMR(CDCl 3 ) δ 2.55(s, 3H), 2.67(s, 3H), 3.58(s, 3H), 3.79(s, 3H), 5.18(s, 2H), 5.71(s, 1H), 6.85(s, 1H), 6.91(d.d, J=8.4&amp; 
               
               
                   
                 2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.04(d, J=2.1Hz, 1H), 7.32–7.48(m, 6H), .7.85(.d.d, J=7.8&amp;1.5Hz, 1H), 8.22(d, J=1.5Hz, 1H) 
               
               
                   
                 IR(KBr)3457, 1739, 1529, 1481, 1407, 1376, 1346, 1279, 1243, 1177, 1128, 1071, 1012cm −1   
               
               
                 I-640 
                   1 HNMR(CDCl 3 ) δ 2.67(s, 3H), 2.68(s, 3H), 3.13(s, 3H), 3.58(s, 3H), 3.80(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.15(d, J=8.7Hz, 1H), 7.31–7.49 
               
               
                   
                 (m, 8H), 7.83(d.d, J=8.1&amp;1.8Hz, 1H), 8.21(d, J=1.8Hz, 1H) 
               
               
                   
                 IR(KBr)3433, 1609, 1530, 1481, 1372, 1290, 1268, 1238, 1177, 1118, 1075, 1012cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 127 
               
               
                   
               
             
            
               
                 I-641 
                   1 HNMR(CDCl 3 ) δ 2.67(s, 3H), 3.50(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 5.70(s, 1H), 5.83(s, 1H), 6.47(s, 1H), 6.94(d.d, J=8.7&amp; 
               
               
                   
                 1.8Hz, 1H), 7.04(.d, J=8.7Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.34–7.48(m, 5H), 7.82(d.d, J=8.1&amp;1.8Hz, 1H), 8.26(.d, J=1.8Hz, 1H) 
               
               
                   
                 IR(KBr)3555, 3377, 1590, 1529, 1503, 1451, 1414, 1341, 1324, 1242, 1225, 1121cm −1   
               
               
                 I-642 
                   1 HNMR(CDCl 3 ) δ 2.29(s, 3H), 2.68(s, 3H), 3.12(s, 3H), 3.56(s, 3H), 3.76(s, 3H), 5.18(s, 2H), 6.85(s, 1H), 7.00–7.20(m, 4H), 7.31–7.49 
               
               
                   
                 (m, 7H) 
               
               
                   
                 IR(KBr)3407, 1624, 1518, 1480, 1361, 1287, 1270, 1234, 1175, 1117, 1084, 1009cm −1   
               
               
                 I-643 
                   1 HNMR(CDCl 3 ) δ 2.40(s, 3H), 2.67(s, 3H), 3.09(s, 3H), 3.13(s, 3H), 3.59(s, 3H), 3.78(s, 3H), 5.19(s, 1H), 6.17(s, 1H), 6.85(s, 1H), 7.15 
               
               
                   
                 (d, J=8.4Hz, 1H), 7.30–7.49(m, 9H), 7.69(d, J=1.8Hz, 1H) 
               
               
                   
                 IR(KBr)3433, 3304, 1608, 1519, 1481, 1365, 1326, 1294, 1269, 1237, 1177, 1156, 1114, 1079, 1015cm −1   
               
               
                 I-644 
                   1 HNMR(CDCl 3 ) δ 2.09(s, 3H), 2.39(s, 3H), 2.68(s, 3H), 3.13(s, 3H), 3.49(s, 3H), 3.76(s, 2H), 5.19(s, 2H), 6.30(s, 1H), 6.77(s, 1H), 7.12–7.24 
               
               
                   
                 (m, 3H), 7.31–7.49(m, 9H), 7.54(d, J=1.8Hz, 1H), 7.67(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3434, 1608, 1519, 1481, 1366, 1293, 1269, 1237, 1164, 1114, 1081, 1016cm  −1   
               
               
                 I-645 
                   1 HNMR(CDCl 3 ) δ 2.09(s, 3H), 2.39(s, 3H), 3.43(s, 3H), 3.73(s, 3H), 5.16(s, 2H), 5.30(s, 1H), 5.68(s, 1H), 5.89(s, 1H), 6.32(s, 1H), 
               
               
                   
                 6.36(s, 1H), 6.95(d.d, J=8.7&amp;2.1Hz, 1H), 7.03(d, J=8.7Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.14–7.28(m, 3H), 7.34–7.50(m, 5H), 7.61(.d, 
               
               
                   
                 J=1.5Hz, 1H), 7.68(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3465, 3270, 1612, 1587, 1558, 1519, 1487, 1454, 1384, 1244, 1160, 1123, 1105, 1091, 1070, 1009cm −1   
               
               
                 I-646 
                   1 HNMR(CDCl 3 ) δ 2.48(s, 3H), 2.63(s, 3H), 3.02(s, 3H), 3.13(s, 3H), 3.28(s, 2H), 3.54(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.15 
               
               
                   
                 (d, J=8.4Hz, 1H), 7.30–7.49(m, 9H), 7.59(s, 1H) 
               
               
                   
                 IR(KBr)3433, 1606, 1519, 1481, 1364, 1341, 1292, 1272, 1233, 1178, 1148, 1118, 1082cm −1   
               
               
                 I-647 
                   1 HNMR(CDCl 3 ) δ 2.48(s, 3H), 3.02(s, 3H), 3.28(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 5.16(s, 2H), 5.70(s, 1H), 5.84(s, 1H), 6.47(s, 1H), 
               
               
                   
                 6.94(d.d, J=8.4&amp;2.1Hz, 1H), 7.03(.d, J=8.4Hz, 1H), 7.07(d, J=2.1Hz, 1H), 7.33–7.53(m, 7H), 7.62(d, J=1.8Hz, 1H) 
               
               
                   
                 IR(KBr)3528, 3429, 1609, 1584, 1558, 1517, 1487, 1454, 1331, 1317, 1137, 1115, 1068, 1002cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 128 
               
               
                   
               
             
            
               
                 I-648 
                   1 HNMR(CDCl 3 ) δ 1.55(s, 3H), 2.45(s, 3H), 2.79(s, 3H), 3.02(s, 3H), 3.29(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 4.12–4.31(m, 2H), 5.22–5.31 
               
               
                   
                 (m, 1H), 6.30(s, 11H), 6.84(s, 1H), 7.17(d, J=8.7Hz, 1H), 7.25–7.32(m, 2H), 7.39(d, J=8.4Hz, 1H), 7.45(d.d, J=8.4&amp;1.8Hz, 1H), 7.53(d, 
               
               
                   
                 J=1.8Hz, 1H) 
               
               
                   
                 IR(KBr)3431, 1609, 1522, 1481, 1365, 1334, 1294, 1235, 1178, 1150, 1077, 1013cm −1   
               
               
                 I-649 
                   1 HNMR(CDCl 3 ) δ 1.54(s, 3H), 1.68(s, 3H), 1.76(s, 3H), 1.81(s, 3H), 2.45(s, 3H), 2.68(s, 3H), 3.02(s, 3H), 3.24(s, 3H), 3.52(s, 3H), 3.78(s, 
               
               
                   
                 3H), 4.10–4.34(m, 2H), 4.64(d, J=7.2Hz, 2H), 5.21–5.30(m, 1H), 5.45–5.53(m, 1H), 6.84(s, 1H), 7.08(d, J=8.4Hz, 1H), 7.31–7.48(m, 4H), 
               
               
                   
                 7.53(d, J=1.5Hz, 1H) 
               
               
                   
                 IR(KBr)3432, 1606, 1518, 1481, 1362, 1340, 1292, 1276, 1236, 1177, 1153, 1116, 1076, 1010cm −1   
               
               
                 I-650 
                   1 HNMR(CDCl 3 ) δ 1.56(s, 3H), 1.68(s, 3H), 1.76(s, 3H), 1.82(s, 3H), 2.44(s, 3H), 3.02(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.10–4.32(m, 2H), 
               
               
                   
                 4.62(d, J=7.2Hz, 2H), 5.22–5.32(m, 1H), 5.48–5.57(m, 1H), 5.60–5.80(brroad, 1H), 5.82(s, 1H), 6.46(s, 1H), 6.92(d.d, J=8.1 
               
               
                   
                 &amp;1.8Hz, 1H), 6.97(d, J=8.1Hz, 1H), 7.04(d, J=1.8Hz, 1H), 7.38(d, J=8.1Hz, 1H), 7.47(d.d, J=8.1&amp;1.8Hz, 1H), 7.57(d, 
               
               
                   
                 J=1.8Hz, 1H) 
               
               
                   
                 IR(KBr)3433, 1610, 1586, 1557, 1518, 1486, 1336, 1240, 1149, 1110, 1069cm −1   
               
               
                 I-651 
                   1 HNMR(CD 3 OD) δ 3.33(s, 3H), 3.66(s, 3H), 5.18(s, 2H), 6.42(s, 1H), 1H), 6.75(dd, J=8.4&amp;2.1Hz, 1H), 6.87(d, J=2.1Hz, 1H), 6.95(d, J=8.4Hz, 
               
               
                   
                 1H), 7.26–7.58(m, 8H), 7.81(d.d, J=7.8&amp;1.2Hz, 1H) 
               
               
                   
                 IR(KBr)3446, 1698, 1586, 1517, 1498, 1481, 1454, 1408, 1287, 1247, 1117, 1069, 1010cm −1   
               
               
                 I-652 
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.76(s, 3H), 3.23(s, 3H), 3.43(s, 3H), 3.72(s, 3H), 3.76(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.50(t, 
               
               
                   
                 J=6.6Hz, 1H), 6.78(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.33–7.51(m, 4H), 7.56–7.63(m, 1H), 7.96(d.d, J=7.5&amp;1.2Hz, 1H) 
               
               
                   
                 IR(KBr)1725, 1609, 1520, 1480, 1400, 1366, 1295, 1260, 1178, 1119, 1073, 1010cm −1   
               
               
                 I-653 
                   1 HNMR(CDCl 3 ) δ 2.38(s, 3H), 2.72(s, 3H), 3.12(s, 3H), 3.43(s, 3H), 3.73(s, 3H), 3.76(s, 3H), 5.14(s, 2H), 6.79(s, 1H), 7.13–7.24(m, 3H), 
               
               
                   
                 7.30–7.38(m, 3H), 7.41–7.51(m, 3H), 7.56–7.63(m, 1H), 795(d.d, J=7.5&amp;1.2Hz, 1H) 
               
               
                   
                 IR(KBr)1725, 1610, 1520, 1481, 1401, 1370, 1293, 1262, 1179, 1119, 1076, 1011cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 129 
               
               
                   
               
             
            
               
                 I-654 
                   1 HNMR(CDCl 3 ) δ 1.75(s, 3H), 1.81(s, 3H), 3.56(s, 3H), 3.72(s, 3H), 4.60(d, J=6.6Hz, 2H), 5.29(s, 1H), 5.46–5.56(m, 1H), 5.56–6.00(broad, 
               
               
                   
                 1H), 6.42(s, 1H), 6.94(s, 2H), 7.05(s, 1H), 7.43–7.52(m, 2H), 7.56–7.65(m, 1H), 7.99(.d, J=8.7Hz, 1H) 
               
               
                   
                 IR(KBr)3433, 1697, 1585, 1517, 1481, 1454, 1410, 1287, 1244, 1117, 1068cm −1   
               
               
                 I-655 
                   1 HNMR(CDCl 3 ) δ 2.39(s, 3H), 3.37(s, 3H), 3.72(s, 3H), 5.10(s, 2H), 6.41(s, 1H), 6.94(dd, J=8.1&amp;2.1Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.06 
               
               
                   
                 (d, J=2.1Hz, 1H), 7.23(d, J=7.8Hz, 2H), 7.35(.d, J=7.8Hz, 2H), 7.42–7.63(m, 3H), 7.96(d, J=7.8Hz, 1H) 
               
               
                   
                 IR(KBr)3538, 3443, 1685, 1518, 1458, 1413, 1253, 1116, 1069, 1010cm −1   
               
               
                 I-656 
                 m.p. 110–112° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.74(s, 3H), 2.55(q, J=7.1Hz, 2H), 3.20(s, 3H), 3.21(s, 3H), 3.39(s, 3H), 3.70(s, 3H), 4.07(t, J=7.1Hz, 2H), 
               
               
                   
                 5.22(t, J=7.1Hz, 1H), 6.28(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.32(dd, J=8.4, 2.0Hz, 1H), 7.36(d, J=8.9Hz, 2H), 7.37(d, J=2.0Hz, 1H), 7.69 
               
               
                   
                 (d, J=8.9Hz, 2H)IR(KBr)3477, 3402, 1607, 1518, 1481, 1365, 1151, 1111, 872, 813cm −1   
               
               
                 I-657 
                 m.p. 159–162° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.64(s, 3H), 1.71(s, 3H), 2.45(q, J=6.7Hz, 2H), 3.27(s, 3H), 3.59(s, 3H), 3.96(t, J=6.7Hz, 2H), 4.22(s, 2H), 5.26(t, 
               
               
                   
                 J=6.7Hz, 1H), 6.17(s, 1H), 6.60(dd, J=8.1, 2.0Hz, 1H), 6.67(d, J=2.0Hz, 1H), 6.83(d, J=8.7Hz, 2H), 6.95(d, J=8.1Hz, 1H), 7.42(d, J=8.7Hz, 
               
               
                   
                 2H), 8.89(s, 1H), 9.46(s, 1H) 
               
               
                   
                 IR(KBr)3447, 3401, 3361, 1611, 1522, 1486, 1260, 1228, 1122, 1001, 814cm −1   
               
               
                 I-658 
                 m.p. 146–147° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.14(t, J=7.2Hz, 3H), 1.76(d, J=0.9Hz, 3H), 1.81(d, J=0.3Hz, 3H), 2.70(s, 3H), 3.20(s, 3H), 3.23(s, 3H), 3.72(q, J=7.2Hz, 
               
               
                   
                 2H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.49(m, 1H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.31–7.41(m, 4H), 7.66–7.74(m, 2H) 
               
               
                   
                 IR(CHCl 3 )2930, 1608, 1517, 1479, 1369, 1148, 1116, 1082, 969, 872cm −1   
               
               
                 I-659 
                 m.p. 174–175° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.14(t, J=6.9Hz, 3H), 2.37(s, 3H), 2.65(s, 3H), 3.12(s, 3H), 3.20(s, 3H), 3.72(q, J=6.9Hz, 2H), 3.77(s, 3H), 5.14(s, 2H), 
               
               
                   
                 6.84(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.18–7.42(m, 6H), 7.66–7.73(m, 2H) 
               
               
                   
                 IR(CHCl 3 )1517, 1479, 1369, 1268, 1148, 1117, 1082, 969, 872cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 130 
               
               
                   
               
             
            
               
                 I-660 
                 m.p. 147.5–148° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.14(t, J=7.2Hz, 3H), 1.68(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.50–2.59(m, 2H), 2.72(s, 3H), 3.20(s, 3H), 3.22(s, 3H), 3.72 
               
               
                   
                 (q, J=7.2Hz, 2H), 3.77(s, 3H), 4.07(d, J=6.9Hz, 2H), 5.21(m, 1H), 6.84(s, 1H), 7.07(d, J=8.7Hz, 1H), 7.31–7.42(m, 4H), 7.66–7.74(m, 2H) 
               
               
                   
                 IR(CHCl 3 )2930, 1607, 1517, 1480, 1369, 1148, 1118, 1082, 1025, 969, 872cm −1   
               
               
                 I-661 
                 m.p. 154–157° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.15(t, J=7.2Hz, 3H), 1.76(s, 3H), 1.82(s, 3H), 3.60(q, J=7.2Hz, 2H), 3.75(s, 3H), 4.61(d, J=6.9Hz, 2H), 4.93(s, 1H), 
               
               
                   
                 5.53(m, 1H), 5.69(s, 1H), 5.96(s, 1H), 6.45(s, 1H), 6.80–6.98(m, 4H), 7.07(m, 1H), 7.51–7.58(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3592, 3528, 2976, 2934, 1611, 1521, 1488, 1460, 1384, 1286, 1243, 1169, 1112, 1068, 994, 885, 824cm −1   
               
               
                 I-662 
                 m.p. 130.5–133° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.15(t, J=7.2Hz, 3H), 2.39(s, 3H), 3.59(q, J=7.2Hz, 2H), 3.74(s, 3H), 4.83(s, 1H), 5.10(s, 2H), 5.66(s, 1H), 5.97(s, 1H), 
               
               
                   
                 6.44(s, 1H), 6.87–6.94(m, 2H), 6.96(dd, J=1.8, 8.4Hz, 1H), 7.02(d, J=8.4Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.19–7.26(m, 2H), 7.30–7.38( 
               
               
                   
                 m, 2H), 7.51–7.58(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3524, 1612, 1521, 1488, 1460, 1383, 1286, 1246, 1113, 1069, 1027, 907, 873cm −1   
               
               
                 I-663 
                 amorphous powder 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.15(t, J=7.2Hz, 3H), 1.68(d, J=0.6Hz, 3H), 1.74(d, J=0.9Hz, 3H), 2.48–2.56(m, 2H), 3.60(q, J=7.2Hz, 2H), 3.74(s, 
               
               
                   
                 3H), 4.06(d, J=6.9Hz, 2H), 4.95(s, 1H), 5.22(m, 1H), 5.68(s, 1H), 5.96(s, 1H), 6.44(s, 1H), 6.88–6.99(m, 4H), 7.06(d, J=1.2Hz, 1H), 7.51–7.58 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(CHCl 3 )3528, 2972, 1611, 1521, 1488, 1384, 1286, 1246, 1112, 1068, 1024, 883, 824cm −1   
               
               
                 I-664 
                 m.p. 113–116° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.55(s, 6H), 3.45(s, 3H), 3.74(s, 3H), 5.31(s, 2H), 6.44(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.94(dd, J=8.4, 2.1Hz, 1H), 7.10 
               
               
                   
                 (s, 1H), 7.10(d, J=2.1Hz, 1H), 7.20(d, J=8.7Hz, 1H), 7.52(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3491, 3443, 3304, 3155, 1662, 1608, 1523, 1492, 1464, 1251, 1215, 1111, 1067, 811, 782cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 131 
               
               
                   
               
             
            
               
                 I-665 
                 m.p.&gt;260° C. 
               
               
                   
                   1 HNMR(CD 3 OD) δ 3.39(s, 3H), 3.68(s, 3H), 5.40(s, 2H), 6.44(s, 1H), 6.83(dd, J=8.4, 2.1Hz, 1H), 6.85(d, J=8.7, 2H), 
               
               
                   
                 6.90(d, J=2.1Hz, 1H), 7.11 (d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3350, 2668, 1611, 1595, 1530, 1488, 1458, 1402, 1253, 1213, 1116, 1073, 1016, 837, 817, 781cm −1   
               
               
                 I-666 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.34(s, 3H), 2.44(s, 3H), 2.83(s, 3H), 3.12(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 4.92(s, 2H), 
               
               
                   
                 6.85(s, 1H), 7.17(d, J=8.4Hz, 1H), 7.37–7.42(m, 2H), 7.39(d, J=8.7Hz, 2H), 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)1638, 1608, 1519, 1480, 1459, 1177, 1151, 1079, 971, 876, 844, 798cm −1   
               
               
                 I-667 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.07(s, 3H), 2.53(s, 3H), 2.96(s, 3H), 3.23(s, 3H), 3.27(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 4.86(s, 2H), 
               
               
                   
                 6.86(s, 1H), 7.11(d, J=9.0Hz, 1H), 7.33–7.41(m, 2H), 7.39(d, J=8.7Hz, 2H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)1724, 1688, 1610, 1520, 1481, 1464, 1234, 1177, 1151, 1123, 1081, 876, 798cm −1   
               
               
                 I-668 
                 m.p. 221–223° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.30(s, 3H), 3.64(s, 3H), 5.16(s, 2H), 6.39(s, 1H), 6.66(dd, J=8.4, 2.1Hz, 1H), 6.77(d, J=2.1Hz, 1H), 
               
               
                   
                 6.84(d, J=8.7Hz, 2H), 7.00(d, J=8.4Hz, 1H), 7.34(s, 1H), 7.44(d, J=8.7Hz, 2H), 8.43(s, 1H) 
               
               
                   
                 IR(Nujol)3535, 3411, 1611, 1582, 1521, 1488, 1463, 1244, 1194, 1135, 1119, 1074, 1014, 930, 826, 809cm −1   
               
               
                 I-669 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.79(s, 3H), 3.17(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.21(s, 2H), 6.85(s, 1H), 7.19(d, J=8.4Hz, 1H), 
               
               
                   
                 7.23(s, 1H), 7.38(dd, J=8.7, 2.1Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 7.94(s, 1H) 
               
               
                   
                 IR(Nujol)1608, 1519, 1480, 1463, 1177, 1151, 1119, 1079, 971, 876, 798cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 132 
               
               
                   
               
             
            
               
                 I-670 
                 m.p. 198–201° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 2.88(s, 3H), 3.39(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.78(s, 3H), 4.58(s, 2H), 5.60(s, 1H), 7.07(s, 1H), 
               
               
                   
                 7.29(dd, J=9.0, 1.8Hz, 1H), 7.30(d, J=1.8,Hz, 1H), 7.37(d, J=9.0Hz, 1H), 7.48(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H), 9.39(s, 1H) 
               
               
                   
                 IR(Nujol)3576, 3500, 3405, 3391, 1668, 1607, 1590, 1520, 1480, 1462, 1175, 1156, 1081, 1014, 880, 836, 826, 801cm −1   
               
               
                 I-671 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.61(s, 3H), 2.73(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.32(s, 2H), 6.84(s, 1H), 
               
               
                   
                 7.17(d, J=8.4Hz, 1H), 7.36(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7,Hz, 2H), 7.43(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 8.46(s, 1H), 8.75(s, 1H) 
               
               
                   
                 IR(Nujol)1608, 1519, 1481, 1463, 1177, 1151, 1080, 971, 876, 798cm −1   
               
               
                 I-672 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.75(s, 3H), 3.21(s, 3H), 3.25(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.37(s, 2H), 6.84(s, 1H), 7.17(d, J=8.4Hz, 1H), 
               
               
                   
                 7.36(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7,Hz, 2H), 7.43(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 8.59(s, 1H), 8.92(s, 1H) 
               
               
                   
                 IR(Nujol)1608, 1519, 1480, 1463, 1177, 1151, 1080, 971, 876, 798cm −1   
               
               
                 I-673 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.70(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.14(s, 2H), 6.77(m, 2H), 6.84(s, 1H), 7.19(m, 2H), 
               
               
                   
                 7.26(d, J=8.4Hz, 1H), 7.37(d, J=2.1Hz, 1H), 7.38(dd, J=2.1, 8.4Hz, 1H), 7.68(d, J=8.4Hz, 2H) 
               
               
                 I-674 
                 m.p. 153–156° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.18(s, 3H), 2.81(s, 3H), 3.18(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 5.14(s, 2H), 6.86(s, 1H), 
               
               
                   
                 7.18(dd, J=8.1, 8.1Hz, 1H), 7.24(d, J=8.1Hz, 1H), 7.26(d, J=8.4Hz, 1H), 7.36(d, J=1.8Hz, 1H), 7.38(d, J=8.4Hz, 2H), 
               
               
                   
                 7.39(dd, J=1.8, 8.4Hz, 1H), 7.43(dd, J=8.1, 8.1Hz, 1H), 7.67(d, J=8.4Hz, 2H), 7.90(d, J=8.1Hz, 1H) 
               
               
                   
                 IR(KBr)3384, 1689, 1519, 1481, 1364, 1177, 1151, 1079, 970, 874, 798cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 133 
               
               
                   
               
             
            
               
                 1-675 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.76(s, 3H), 3.16(s, 3H), 3.22(s, 3H), 3.23(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.23(s, 2H), 6.85(s, 1H), 7.23(dd, J=7.5, 7.5Hz, 
               
               
                   
                 1H), 7.37(s, 2H), 7.38(d, J=8.4Hz, 2H), 7.43(m, 3H), 7.54(d, J=7.5Hz, 1H), 7.68(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3435, 1609, 1519, 1481, 1364, 1177, 1152, 1079, 972, 876, 798 cm −1   
               
               
                 1-676 
                 m.p.163–165° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.78(s, 3H), 3.03(s, 3H), 3.21(s, 3H), 3.45(s, 6H), 3.55(s, 3H), 3.79(s, 3H), 5.31(s, 2H), 6.84(s, 1H), 7.22(d, J=8.4Hz, 
               
               
                   
                 1H), 7.37(dd, J=2.4, 8.4Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.42(m, 2H), 7.53(m, 2H), 7.67(d, J=8.4Hz, 2H), 7.68(m, 1H) 
               
               
                   
                 IR(KBr)1609, 1519, 1481, 1365, 1176, 1161, 1080, 973, 875, 799 cm −1   
               
               
                 1-677 
                 m.p. 153–156° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.69(s, 3H), 2.98(s, 3H), 3.17(s, 3H), 3.21(s, 3H), 3.33(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.44(s, 2H), 6.84(s, 1H), 7.21(d, 
               
               
                   
                 J=8.7Hz, 1H), 7.31–7.46(m, 5H), 7.38(d, J=8.4Hz, 2H), 7.68(d, J=8.4Hz, 2H), 7.72(m, 1H) 
               
               
                   
                 IR(KBr)1610, 1519, 1481, 1365, 1177, 1149, 1079, 963, 876, 799 cm −1   
               
               
                 1-678 
                 foam 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.60(s, 3H), 2.75(s, 6H), 3.17(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.31(s, 2H), 6.83(s, 1H), 7.08(dd, J=7.5, 7.5Hz, 
               
               
                   
                 1H), 7.16(d, J=8.4Hz, 1H), 7.17(d, J=7.5Hz, 1H), 7.30(dd, J=2.1, 8.4Hz, 1H), 7.32(dd, J=7.5, 7.5Hz, 1H), 7.37(d, J=8.4Hz, 2H), 
               
               
                   
                 7.38(d, J=2.1Hz, 1H), 7.52(d, J=7.5Hz, 1H), 7.68(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1609, 1519, 1480, 1365, 1235, 1177, 1151, 1079, 970, 874, 797 cm 1   
               
               
                 1-679 
                 m.p. 95–97° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(s, 3H), 3.03(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.75(s, 3H), 4.63(d, J=6.9Hz, 2H), 4.93(s, 2H), 5.51(m, 
               
               
                   
                 1H), 6.66(s, 1H), 7.05(d, J=8.4Hz, 1H), 7.09–7.17(m, 2H), 7.37(dd, J=2.4, 8.4Hz, 1H), 7.44(d, J=2.4Hz, 1H), 7.51–7.58(m, 2H) 
               
               
                   
                 IR(KBr)3435, 2936, 1605, 1519, 1475, 1382, 1365, 1232, 1161, 1109, 1080 cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 134 
               
               
                   
               
             
            
               
                 I-680 
                 m.p. 142–144° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 3.07(s, 3H), 3.57(s, 3H), 3.74(s, 3H), 4.61(d, J=6.6Hz, 2H), 4.90(s, 2H), 5.51(m, 1H), 5.65(s, 
               
               
                   
                 1H), 6.66(s, 1H), 6.92(m, 2H), 7.03(m, 1H), 7.09–7.17(m, 2H), 7.52–7.58(m, 2H) 
               
               
                   
                 IR(KBr)3455, 2964, 2932, 1606, 1583, 1519, 1479, 1387, 1283, 1227, 1153, 1115, 1080, 1094, 1004cm −1   
               
               
                 I-681 
                 m.p. 158–160° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 3.20(s, 3H), 3.42(s, 3H), 3.76(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.51(m, 1H), 6.04(s, 1H), 6.43(s, 1H), 
               
               
                   
                 7.07(d, J=8.4Hz, 1H), 7.11–7.19(m, 2H), 7.42(dd, J=2.1, 8.4Hz, 1H), 7.50(d, J=2.1Hz, 1H), 7.58–7.65(m, 2H) 
               
               
                   
                 IR(KBr)3505, 3440, 1613, 1522, 1489, 1386, 1352, 1292, 1227, 1109, 1013cm −1   
               
               
                 I-682 
                 m.p. 175–178° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.63(s, 3H), 1.92–2.13(m, 4H), 3.22(s, 3H), 3.42(s, 3H), 3.76(s, 3H), 4.13(t, J=6.3Hz, 2H), 6.04(s, 1H), 6.44(s, 1H), 7.06 
               
               
                   
                 (d, J=8.4Hz, 1H), 7.11–7.19(m, 2H), 7.43(dd, J=2.1, 8.4Hz, 1H), 7.49(d, J=2.1Hz, 1H), 7.57–7.65(m, 2H) 
               
               
                   
                 IR(KBr)3467, 2973, 2943, 1613, 1523, 1489, 1359, 1232, 1113, 1072cm −1   
               
               
                 I-683 
                 powder 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.75(s, 3H), 2.48–2.57(m, 2H), 3.08(s, 3H), 3.57(s, 3H), 3.74(s, 3H), 4.06(t, J=6.9Hz, 2H), 4.90(s, 2H), 5.22 
               
               
                   
                 (m, 1H), 5.64(s, 1H), 6.66(s, 1H), 6.91(m, 2H), 7.03(m, 1H), 7.08–7.17(m, 2H), 7.52–7.59(m, 2H) 
               
               
                   
                 IR(KBr)3432, 2930, 1604, 1583, 1518, 1475, 1382, 1280, 1249, 1222, 1160, 1111, 1082cm −1   
               
               
                 I-684 
                 m.p. 151–153° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.73(s, 3H), 2.50–2.59(m, 2H), 3.19(s, 3H), 3.42(s, 3H), 3.76(s, 3H), 4.06(t, J=6.9Hz, 2H), 5.21(m, 1H), 6.02 
               
               
                   
                 (s, 1H), 6.43(s, 1H), 7.05(d, J=8.4Hz, 1H), 7.11–7.19(m, 2H), 7.42(dd, J=2.4, 8.4Hz, 1H), 7.50(d, J=2.4Hz, 1H), 7.57–7.65(m, 2H) 
               
               
                   
                 IR(KBr)3457, 2937, 1613, 1523, 1489, 1465, 1390, 1361, 1295, 1234, 1185, 1110, 1072, 1013cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 135 
               
               
                   
               
             
            
               
                 I-685 
                 m.p. 156–158° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 3.21(s, 3H), 3.42(s, 3H), 3.76(s, 3H), 4.54(d, J=6.9Hz, 2H), 5.52(t, J=6.9Hz, 1H), 6.94(s, 1H), 
               
               
                   
                 6.94(d, J=8.7Hz, 2H), 7.29(d, J=8.7Hz, 2H), 7.37(d, J=8.7Hz, 2H), 7.71(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)1734, 1517, 1464, 1360, 1237, 1150, 1061, 988, 862cm −1   
               
               
                 I-686 
                 m.p. 189–191° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.21(s, 3H), 3.21(s, 3H), 3.42(s, 3H), 3.61(s, 3H), 3.76(s, 3H), 5.09(s, 2H), 6.94(s, 1H), 7.10(d, J=8.4Hz, 2H), 7.28–7.48 
               
               
                   
                 (m, 9H), 7.71(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)1727, 1518, 1469, 1365, 1239, 1152, 1061, 865cm −1   
               
               
                 I-687 
                 m.p. 112–113° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.68(s, 3H), 1.74(s, 3H), 2.50(q, J=7.2Hz, 2H), 3.21(s, 3H), 3.42(s, 3H), 3.62(s, 3H), 3.76(s, 3H), 3.96(t, J=7.2Hz, 2H), 5.23 
               
               
                   
                 (t, J=7.2Hz, 1H), 6.92(d, J=8.8Hz, 2H), 6.93(s, 1H), 7.28(d, J=8.8Hz, 2H), 7.37(d, J=8.8Hz, 2H), 7.71(d, J=8.8Hz, 2H) 
               
               
                   
                 IR(KBr)1735, 1519, 1469, 1361, 1246, 1153, 1059, 877, 861, 847, 791cm −1   
               
               
                 I-688 
                 m.p. 191–193° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.73(s, 3H), 1.76(s, 3H), 3.31(s, 3H), 3.71(s, 3H), 4.54(d, J=6.9Hz, 2H), 5.46(t, J=6.9Hz, 1H),(s, 1H), 6.87(d, J=8.7Hz, 
               
               
                   
                 2H), 6.91(s, 1H), 6.92(d, J=8.7Hz, 2H), 7.19(d, J=8.7Hz, 2H), 7.48(d, J=8.7Hz, 2H), 9.59(s, 1H), 12.8(brs, 1H) 
               
               
                   
                 IR(KBr)3462, 1695, 1609, 1520, 1472, 1231, 1177, 1062, 1001, 837cm −1   
               
               
                 I-689 
                 m.p. 229–232° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 3.31(s, 3H), 3.71(s, 3H), 5.12(s, 2H), 6.87(d, J=8.8Hz, 2H), 6.98(s, 1H), 7.01(d, J=8.8Hz, 2H), 7.21(d, J=8.8Hz, 2H), 
               
               
                   
                 7.34–7.50(m, 7H), 9.58(s, 1H), 12.8(brs, 1H) 
               
               
                   
                 IR(KBr)3424, 3238, 1685, 1610, 1521, 1464, 1379, 1235, 1180, 1057, 1001, 826cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 136 
               
               
                   
               
             
            
               
                 I-690 
                 m.p. 171–172° C. 
               
               
                   
                   1 HNMR(DMSO-d 6 ) δ 1.64(s, 3H), 1.70(s, 3H), 2.43(q, J=6.9Hz, 2H), 3.31(s, 3H), 3.70(s, 3H), 3.96(t, J=6.9Hz, 2H), 5.23(t, J=6.9Hz, 1H), 6.87 
               
               
                   
                 (d, J=8.8Hz, 2H), 6.91(d, J=8.8Hz, 2H), 6.98(s, 1H), 7.19(d, J=8.8Hz, 2H), 7.48(d, J=8.8Hz, 2H), 9.58(s, 1H), 12.8(brs, 1H) 
               
               
                   
                 IR(KBr)3402, 3266, 1689, 1612, 1521, 1470, 1376, 1241, 1181, 1063, 1001, 829cm −1   
               
               
                 I-691 
                 mp 191–193° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.55(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 5.17(s, 2H), 5.70(s, 1H), 6.83(s, 1H), 6.91(dd, J=1.8, 8.1Hz, 1H), 7.00–7.05 
               
               
                   
                 (m, 2H), 7.10–7.19(m, 2H), 7.34–7.45(m, 5H), 7.57–7.65(m, 2H) 
               
               
                   
                 IR(KBr)3030, 2934, 1606, 1523, 1487, 1391, 1358, 1290, 1228, 1077, 1019, 947, 831, 815, 803cm −1   
               
               
                 I-692 
                 mp 172–173° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.47(s, 3H), 3.52(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 5.21(s, 2H), 5.25(s, 2H), 6.82(s, 1H), 7.01–7.03(m, 2H), 7.11–7.18 
               
               
                   
                 (m, 2H), 7.22–7.41(m, 6H), 7.57–7.63(m, 2H) 
               
               
                   
                 IR(KBr)3010, 2931, 1602, 1519, 1484, 1385, 1369, 1232, 1174, 1085, 847, 806, 729, 527cm −1   
               
               
                 I-693 
                 mp 129–132° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 3.44(s, 3H), 3.53(s, 3H), 3.75(s, 3H), 5.20(s, 2H), 5.26(s, 2H), 5.91(s, 1H), 6.44(s, 1H), 7.01(d, J=8.1Hz, 1H), 
               
               
                   
                 7.08(dd, J=1.8Hz, 8.1Hz, 1H), 7.11–7.18(m, 2H), 7.28–7.50(m, 6H), 7.57–7.64(m, 2H) 
               
               
                   
                 IR(KBr)2996, 2952, 2932, 2895, 1609, 1522, 1488, 1229, 1120, 1075, 999, 911, 815, 724, 582cm −1   
               
               
                 I-694 
                 mp 124–126° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.76(d, J=0.6Hz, 3H), 1.80(d, J=0.9Hz, 3H), 2.69(2H, s), 3.54(s, 3H), 3.57(s, 3H), 3.76(s, 3H), 
               
               
                   
                 4.64(d, J=6.6Hz, 2H), 5.26(s, 3H), 5.54(m, 1H), 6.86(s, 1H), 6.98(d, J=8.7Hz, 1H), 7.13–7.25(m, 3H), 7.38–7.43(m, 3H) 
               
               
                   
                 IR(CHCl 3 )2935, 2855, 1675, 1603, 1520, 1481, 1387, 1370, 1247, 1178, 1158, 1134, 1081, 1003, 961, 839, 814cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 137 
               
               
                   
               
             
            
               
                 I-695 
                 mp 141–142° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.34(s, 3H), 2.48(s, 3H), 5.16(s, 2H), 5.70(s, 1H), 6.82(dd, J=8.4, 2.1Hz, 1H), 6.97–7.00(m, 2H), 7.07–7.13 
               
               
                   
                 (m, 4H), 7.32–7.46(m, 7H) 
               
               
                   
                 IR(CHCl 3 )3543, 3023, 2871, 1604, 1587, 1520, 1489, 1469, 1383, 1267, 1243, 1158, 1126, 1014, 957, 877, 839cm −1   
               
               
                 I-696 
                 mp 178–180° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.75(s, 3H), 3.18(s, 3H), 3.55(s, 3H), 3.76(s, 3H), 5.18(s, 2H), 5.72(s, 1H), 6.87(s, 1H), 7.00(d, J=8.7Hz, 1H), 
               
               
                   
                 7.15(dd, J=8.7, 2.1Hz, 1H), 7.24–7.28(m, 2H), 7.36–7.50(m, 8H) 
               
               
                   
                 IR(CHCl 3 )3543, 3027, 2939, 1519, 1481, 1371, 1330, 1254, 1204, 1177, 1150, 1082, 1005, 969, 873cm −1   
               
               
                 I-697 
                 mp 129–130° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.24(s, 3H), 2.29(s, 3H), 3.12(s, 3H), 5.18(s, 2H), 7.08–7.14(m, 5H), 7.25–7.50(m, 9H) 
               
               
                   
                 IR(CHCl 3 )2925, 2871, 1604, 1520, 1490, 1455, 1369, 1291, 1262, 1169, 1111, 1007, 972, 957, 882, 840, 816cm −1   
               
               
                 I-698 
                 mp 124–125° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.77(s, 3H), 1.81–1.82(d, J=0.9Hz, 3H), 2.24(s, 3H), 2.28(s, 3H), 3.22(s, 3H), 4.63(d, J=6.6Hz, 2H), 
               
               
                   
                 5.52(m, 1H), 7.04–7.14(m, 5H), 7.24–7.34(m, 4H) 
               
               
                   
                 IR(KBr)2978, 2924, 2868, 1893, 1771, 1604, 1520, 1489, 1368, 1290, 1261, 1169, 1109, 1046, 973, 957, 882, 740, 816cm −1   
               
               
                 I-699 
                 oil 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 1.69(s, 3H), 1.74–1.75(d, J=0.9Hz, 3H), 2.24(s, 3H), 2.28(s, 3H), 2.55(m, 2H), 3.21(s, 3H), 4.05–4.10 
               
               
                   
                 (t, J=6.9Hz, 2H), 5.22(m, 1H), 7.03–7.14(m, 5H), 7.24–7.34(m, 4H) 
               
               
                   
                 IR(CHCl 3 )2970, 2926, 2875, 1605, 1520, 1490, 1470, 1368, 1292, 1277, 1169, 1110, 1016, 973, 958, 878, 840, 819cm −1   
               
               
                 I-700 
                 mp 121–123° C. 
               
               
                   
                   1 HNMR(CDCl 3 ) δ 2.24(s, 3H), 2.83(s, 3H), 2.98(s, 3H), 3.11(s, 3H), 5.13(s, 2H), 7.08–7.14(m, 4H), 7.21–7.37(m, 9H) 
               
               
                   
                 IR(CHCl 3 )2925, 1605, 1520, 1489, 1369, 1262, 1169, 1014, 1003, 972, 957, 882, 840, 816cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 138 
               
               
                   
               
             
            
               
                 I-701 
                 mp 215–217° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.73(s, 3H), 3.13(s, 3H), 3.18(s, 3H), 3.57(s, 3H), 3.78(s, 3H), 5.20(s, 2H), 6.86(s, 1H), 7.16(d, J=8.7Hz, 
               
               
                   
                 1H), 7.35–7.50(m, 9H), 7.56(dd, J=8.4, 2.4Hz, 1H), 7.62(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(CHCl 3 ) 2939, 1613, 1519, 1480, 1371, 1294, 1254, 1176, 1150, 1119, 1083, 1003, 970, 871, 849, 816cm −1   
               
               
                 I-702 
                 mp 71–73° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.83(s, 3H), 2.24(s, 3H), 2.29(s, 3H), 4.61–4.64(d, J=6.9Hz, 2H), 5.54(m, 1H), 5.71(s, 
               
               
                   
                 1H), 6.80–6.84(dd, J=8.4, 2.1Hz, 1H), 6.92(d, J=8.4Hz, 1H), 7.07–7.13(m, 4H), 7.30–7.35(m, 2H) 
               
               
                   
                 IR(KBr) 3537, 2977, 2924, 2868, 1604, 1585, 1520, 1489, 1450, 1386, 1292, 1267, 1242, 1158, 1125, 996, 957, 839cm −1   
               
               
                 I-703 
                 oil 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.69(s, 3H), 1.75–1.76(d, J=0.9Hz, 3H), 2.24(s, 3H), 2.28(s, 3H), 2.50–2.57(td, J=6.9, 6.3Hz, 2H), 
               
               
                   
                 4.05–4.10(t, J=6.3Hz, 2H), 5.24(m, 1H), 5.70(s, 1H), 6.81(dd, J=8.4, 1.8Hz, 1H), 6.90(d, J=8.4Hz, 1H), 6.96(d, J=1.8Hz, 
               
               
                   
                 1H), 7.06–7.13(m, 4H), 7.26–7.34(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3540, 2972, 2925, 2877, 1604, 1585, 1520, 1490, 1387, 1293, 1267, 1245, 1158, 1127, 1016, 957, 839cm −1   
               
               
                 I-704 
                 mp 113–115° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.24(s, 3H), 2.28(s, 3H), 2.39(s, 3H), 5.11(s, 2H), 5.69(s, 1H), 6.82(dd, J=8.4, 2.4Hz, 1H), 6.97–7.00 
               
               
                   
                 (m, 2H), 7.07–7.13(m, 3H), 7.22–7.36(m, 7H) 
               
               
                   
                 IR(CHCl 3 ) 3541, 2925, 2871, 1604, 1586, 1520, 1490, 1469, 1380, 1324, 1308, 1292, 1267, 1243, 1201, 1158, 1126, 1013, 
               
               
                   
                 957, 876, 839cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 139 
               
               
                   
               
             
            
               
                 I-705 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.20(s, 3H), 3.27(s, 3H), 3.43(s, 3H), 3.73(s, 3H), 4.37(br d, J=5.7Hz, 2H), 4.58(s, 2H), 5.16(s, 
               
               
                   
                 2H), 5.68(s, 1H), 6.82(dd, J=8.2, 1.7Hz, 1H), 6.88(s, 1H), 6.97(d, J=1.7Hz, 1H), 6.98(d, J=8.2Hz, 1H), 7.35–7.47(m, 
               
               
                   
                 7H), 7.71(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3464, 1515, 1474, 1369, 1230, 1199, 1176, 1149, 1039, 873cm −1   
               
               
                 I-706 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.42(br s, 1H), 3.12(s, 3H), 3.22(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.49(br s, 1H), 5.18(s, 2H), 6.85(s, 
               
               
                   
                 1H), 7.15(d, J=8.6Hz, 1H), 7.27(dd, J=8.6, 2.0Hz, 1H), 7.35–7.50(m, 8H), 7.71(d, J=8.6Hz, 2H) 
               
               
                   
                 IR(KBr) 3583, 3435, 1519, 1467, 1412, 1229, 1180, 1150, 1022, 875, 849, 798, 742, 706cm −1   
               
               
                 I-707 
                 mp 120–121° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.66(s, 2H), 4.77(s, 2H), 5.15(s, 2H), 5.67(s, 1H), 5.91(s, 1H), 
               
               
                   
                 6.47(s, 1H), 6.96(dd, J=8.4, 1.9Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.09(d, J=1.9Hz, 1H), 7.37–7.47(m, 7H), 7.64(d, J=8.4Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3504, 3461, 1522, 1485, 1466, 1384, 1466, 1384, 1283, 1245, 1197, 1110, 1042, 925, 812, 749cm −1   
               
               
                 I-708 
                 mp 156–158° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.11(s, 3H), 3.21(s, 3H), 3.28(s, 3H), 3.42(s, 3H), 3.73(s, 3H), 4.38(s, 2H), 4.58(s, 2H), 5.18(s, 2H), 
               
               
                   
                 6.88(s, 1H), 7.12(d, J=8.7Hz, 1H), 7.27(dd, J=8.7, 2.1Hz, 1H), 7.35–7.50(m, 8H), 7.70(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1514, 1469, 1360, 1177, 1149, 1099, 1042, 870cm −1   
               
               
                 I-709 
                 mp 188–190° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.70(t, J=5.7Hz, 1H), 3.45(s, 3H), 3.75(s, 3H), 4.77(d, J=5.7Hz, 2H), 5.16(s, 2H), 5.68(s, 1H), 
               
               
                   
                 5.91(s, 1H), 6.47(s, 1H), 6.96(dd, J=8.5, 1.7Hz, 1H), 7.03(d, J=8.5Hz, 1H), 7.09(d, J=1.7Hz, 1H), 7.37–7.48(m, 7H), 
               
               
                   
                 7.65(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 3547, 3492, 3451, 1521, 1487, 1385, 1288, 1249, 1209, 1108, 1011, 746, 702cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 140 
               
               
                   
               
             
            
               
                 I-710 
                 mp 178–180° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.43(br s, 1H), 3.44(s, 3H), 3.72(s, 3H), 4.52(m, 2H), 4.93(s, 1H), 5.15(s, 2H), 5.70(s, 1H), 6.79(dd, 
               
               
                   
                 J=8.1, 2.1Hz, 1H), 6.84(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.93(d, J=2.1Hz, 1H), 7.00(d, J=8.7Hz, 1H), 7.38–7.48(m, 
               
               
                   
                 5H), 7.54(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr) 3447, 3214, 1609, 1518, 1477, 1459, 1391, 1260, 1221, 1008, 984, 833, 799, 751cm −1   
               
               
                 I-711 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.85(s, 3H), 3.22(s, 3H), 3.30(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 5.02(s, 2H), 6.85(s, 1H), 7.08(d, J=8.4Hz, 
               
               
                   
                 1H), 7.32(d, J=2.1Hz, 1H), 7.37(dd, J=8.4, 2.1Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol) 3423, 3320, 3215, 1610, 1519, 1480, 1454, 1176, 1151, 1080, 969, 876, 798cm −1   
               
               
                 I-712 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.62(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 5.28(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(dd, J=8.4, 
               
               
                   
                 2.1Hz, 1H), 7.10(d, J=8.4Hz, 1H), 7.11(d, J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H), 8.50(brs, 1H), 8.60(brs, 1H) 
               
               
                   
                 IR(Nujol) 3207, 1611, 1589, 1523, 1489, 1460, 1227, 1116, 1072, 1014, 943, 822, 759cm −1   
               
               
                 I-713 
                 mp 231–233° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.30(s, 3H), 3.64(s, 3H), 5.28(s, 2H), 6.39(s, 1H), 6.67(dd, J=8.4, 2.1Hz, 1H), 6.80(d, J=2.1Hz, 
               
               
                   
                 1H), 6.84(d, J=8.7Hz, 2H), 7.01(d, J=8.4Hz, 1H), 7.44(d, J=8.7Hz, 2H), 8.64(d, J=2.4Hz, 1H), 8.67(dd, J=2.4, 1.2Hz, 
               
               
                   
                 1H), 8.94(d, J=1.2Hz, 1H) 
               
               
                   
                 IR(Nujol) 3369, 3164, 1612, 1600, 1585, 1522, 1493, 1385, 1255, 1118, 1073, 1013, 934, 824, 798, 778cm −1   
               
               
                 I-714 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.83(s, 3H), 3.22(s, 3H), 3.27(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.18(s, 2H), 6.85(s, 1H), 7.20(d, J=8.4Hz, 
               
               
                   
                 1H), 7.39(d, J=8.7Hz, 2H), 7.40(dd, J=8.4, 2.1Hz, 1H), 7.45(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol) 3264, 1650, 1607, 1517, 1480, 1175, 1150, 1078, 946, 876, 798cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 141 
               
               
                   
               
             
            
               
                 I-715 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.76(s, 3H), 2.77(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.35(s, 2H), 6.84(s, 1H), 
               
               
                   
                 7.25(d, J=8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.38(dd, J=8.4, 2.1Hz, 1H), 7.44(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(Nujol) 1607, 1578, 1519, 1465, 1176, 1151, 1079, 971, 947, 876, 846, 797cm −1   
               
               
                 I-716 
                 mp 227–229° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.87(s, 3H), 3.39(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.79(s, 3H), 5.23(s, 2H), 7.08(s, 1H), 7.33(d, J=2.1Hz, 
               
               
                   
                 1H), 7.35(dd, J=8.4, 2.1Hz, 1H), 7.44(d, J=8.4Hz, 1H), 7.49(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol) 3276, 1651, 1605, 1520, 1480, 1463, 1174, 1150, 1079, 947, 879, 798cm −1   
               
               
                 I-717 
                 m.p 180–181° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.07(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.18(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.99(dd, J=1.8, 
               
               
                   
                 8.4Hz, 1H), 7.08(d, J=1.8Hz, 1H), 7.10(d, J=8.4Hz, 1H), 7.25(t, J=7.2Hz, 1H), 7.44(m, 2H), 7.53(d, J=8.7Hz, 
               
               
                   
                 2H), 7.61(d, J=8.1Hz, 1H) 
               
               
                 I-718 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.06(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 5.17(s, 2H), 6.45(s, 1H), 6.93(d, J=8.7Hz, 2H), 6.98(dd, J=8.7Hz, 
               
               
                   
                 1H), 7.08(d, J=2.1Hz, 1H), 7.10(d, J=8.4Hz, 1H), 7.24(m, 1H), 7.43(m, 2H), 7.51(d, J=8.7Hz, 2H), 7.61(m, 1H) 
               
               
                   
                 IR(KBr) 3430, 1611, 1590, 1523, 1490, 1402, 1323, 1242, 1149, 1112, 1070, 1010, 971, 826cm −1   
               
               
                 I-719 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.80(s, 6H), 3.47(s, 3H), 3.76(s, 3H), 5.08(s, 2H), 6.46(s, 1H), 6.92(d, J=8.7Hz, 3H), 7.10(d, J=2.1Hz, 
               
               
                   
                 1H), 7.15(d, J=8.7Hz, 1H), 7.20(d, J=7.2Hz, 1H), 7.34–7.45(m, 3H), 7.55(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3427, 1611, 1585, 1522, 1488, 1404, 1224, 1113, 1069, 1011, 940, 824, 767cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 142 
               
               
                   
               
             
            
               
                 I-720 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.52(s, 9H), 2.67(s, 3H), 3.19(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.17(s, 2H), 6.54(br.s, 
               
               
                   
                 IH), 7.11(m, 1H), 7.12(d, J=9.0Hz, 1H), 7.25(m, 1H), 7.30(d, J=7.5Hz, 1H), 7.32(dd, J=1.8, 9.0Hz, 1H), 7.36(d, J=8.7Hz, 
               
               
                   
                 2H), 7.41(d, J=1.8Hz, 1H), 7.60(s, 1H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1724, 1610, 1520, 1481, 1366, 1234, 1177, 1153, 1079, 969, 875, 797cm −1   
               
               
                 I-721 
                 m.p 187–191° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.66(s, 3H), 3.17(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.11(s, 2H), 6.65(d, J=8.4Hz, 1H), 
               
               
                   
                 6.81(m, 2H), 6.84(s, 1H), 7.12(d, J=8.7Hz, 1H), 7.17(t, J=8.7Hz, 1H), 7.32(dd, J=2.1, 8.7Hz, 1H), 7.37(d, J=8.7Hz, 
               
               
                   
                 2H), 7.40(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1624, 1606, 1519, 1481, 1361, 1176, 1148, 1081, 980, 876, 780cm −1   
               
               
                 I-722 
                 m.p 143–146° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.18(s, 3H), 2.71(s, 3H), 3.18(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.18(s, 2H), 6.84(s, 1H), 
               
               
                   
                 7.12(d, J=8.7Hz, 1H), 7.17(d, J=7.2Hz, 1H), 7.33(m, 2H), 7.37(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.45(d, J=7.2Hz, 
               
               
                   
                 1H), 7.67(d, J=8.7Hz, 2H), 7.67(m, 1H) 
               
               
                   
                 IR(KBr) 1693, 1609, 1519, 1481, 1364, 1364, 1173, 1149, 1079, 874, 802cm −1   
               
               
                 I-723 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.86(s, 3H), 3.00(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.22(s, 2H), 6.59(s, 1H), 6.85(s, 1H), 
               
               
                   
                 7.10(d, J=8.4Hz, 1H), 7.25(m, 3H), 7.32(d, J=2.1, 8.7Hz, 1H), 7.37(m, 1H), 7.38(d, J=2.1Hz, 1H), 7.38(d, J=8.7Hz, 
               
               
                   
                 1H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1610, 1519, 1480, 1364, 1176, 1150, 1079, 971, 876, 797cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 143 
               
               
                   
               
             
            
               
                 I-724 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3  ) δ 2.74(s, 3H), 3.18(s, 3H), 3.21(s, 3H), 3.43(s, 6H), 3.55(s, 3H), 3.78(s, 3H), 5.24(s, 2H), 6.84(s, 1H), 
               
               
                   
                 7.13(d, J=8.4Hz, 1H), 7.36(dt, J=2.1, 8.4Hz, 1H), 7.37(m, 1H), 7.39(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.51(m, 
               
               
                   
                 2H), 7.61(s, 1H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1609, 1523, 1481, 1353, 1176, 1161, 1080, 890, 799cm −1   
               
               
                 I-725 
                 m.p 147–150° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.79(s, 3H), 2.83(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.35(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.22(s, 2H), 
               
               
                   
                 6.85(s, 1H), 7.11(d, J=8.7Hz, 1H), 7.32–7.46(m, 7H), 7.62(s, 1H), 7.67(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 1608, 1518, 1480, 1364, 1178, 1153, 1077, 968, 795cm −1   
               
               
                 I-726 
                 m.p 224–226° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.85(s, 3H), 2.91(s, 6H), 3.36(s, 3H), 3.45(s, 3H), 3.51(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.69(d, J=8.1Hz, 
               
               
                   
                 1H), 6.76(d, J=8.1Hz, 1H), 6.89(s, 1H), 7.07(s, 1H), 7.20(t, J=8.1Hz, 1H), 7.30(m, 3H), 7.48(d, J=8.7Hz, 2H), 
               
               
                   
                 7.74(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1608, 1519, 1480, 1360, 1178, 1146, 1081, 879, 826cm −1   
               
               
                 I-727 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.82(s, 3H), 3.18(s, 6H), 3.21(s, 3H), 3.53(s, 3H), 3.76(s, 3H), 5.17(s, 2H), 6.84(s, 1H), 7.11(d, J=8.4Hz, 
               
               
                   
                 1H), 7.20(d, J=4.8Hz, 1H), 7.30–7.47(m, 8H), 7.76(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3430, 1677, 1609, 1519, 1481, 1364, 1202, 1177, 1150, 1079, 876, 799cm −1   
               
               
                 I-728 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 5.06(s, 2H), 6.45(s, 1H), 6.68(d, J=7.5Hz, 1H), 6.77(s, 1H), 6.82(d, J=7.5Hz, 
               
               
                   
                 1H), 6.91(d, J=8.7Hz, 2H), 6.93(dd, J=1.8, 8.4Hz, 1H), 6.99(d, J=8.4Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.19(t, J=7.5Hz, 
               
               
                   
                 1H), 7.54(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3413, 1611, 1522, 1488, 1461, 1405, 1251, 1119, 1076, 1007, 813, 784cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 144 
               
               
                   
               
             
            
               
                 I-729 
                 m.p 90–93° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.01(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.16(s, 2H), 6.45(s, 1H), 6.81(s, 1H), 6.92(d, J=8.7Hz, 2H), 
               
               
                   
                 6.95(d, J=1.8Hz, 1H), 6.96(m, 2H), 7.24(m, 2H), 7.40(t, J=7.2Hz, 1H), 7.52(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3434, 1612, 1592, 1523, 1489, 1325, 1248, 1224, 1147, 1113, 1070, 1010, 972cm −1   
               
               
                 I-730 
                 mp 79–81° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.34(s, 6H), 3.48(s, 3H), 3.76(s, 3H), 4.72(brs, 1H), 5.16(s, 2H), 5.68(brs, 1H), 5.93(brs, 1H), 6.44 
               
               
                   
                 (s, 1H), 6.99–7.10(m, 3H), 7.26–7.49(m, 7H) 
               
               
                   
                 IR(KBr) 3467, 2933, 1613, 1701, 1517, 1482, 1454, 1424, 1389, 1321, 1196, 1148, 1113, 1073cm −1   
               
               
                 I-731 
                 mp 189–191° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.20(s, 3H), 3.81(s, 6H), 5.14(s, 2H), 5.65(brs, 1H), 6.79(s, 2H), 6.79–7.02(m, 5H), 7.36–7.46(m, 
               
               
                   
                 6H), 7.66(d, J=8.6Hz, 2H) 
               
               
                   
                 IR(KBr) 3439, 2937, 1594, 1567, 1523, 1487, 1351, 1240, 1202, 1146, 1126, 874cm −1   
               
               
                 I-732 
                 mp 196–197° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 3.32(s, 3H), 3.43(s, 6H), 3.79(s, 6H), 5.24(s, 2H), 7.00(s, 2H), 7.23–7.30(m, 3H), 7.35–7.55(m, 
               
               
                   
                 7H), 7.88(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 3434, 1602, 1561, 1523, 1485, 1362, 1288, 1238, 1201, 1181, 1148, 1126, 1115, 966, 914, 813cm −1   
               
               
                 I-733 
                 mp 202–203° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.40(s, 6H), 3.31(s, 3H), 3.34(s, 3H), 3.51(s, 3H), 3.58(s, 3H), 3.77(s, 3H), 5.27(s, 2H), 7.03(s, 
               
               
                   
                 1H), 7.32–7.530(m, 10H) 
               
               
                   
                 IR(KBr) 3434, 3028, 2944, 1515, 1475, 1463, 1361, 1290, 1272, 1247, 1179, 1085, 967, 815, 804cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 145 
               
               
                   
               
             
            
               
                 I-734 
                 mp 140–141° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 3.21(s, 3H), 3.83(s, 6H), 4.63(d, J=4.6Hz, 2H), 5.52–5.53(m, 1H), 6.79(s, 
               
               
                   
                 2H), 7.05(d, J=8.8Hz, 1H), 7.29–7.42(m, 4H), 7.67(d, J=8.6Hz, 2H) 
               
               
                   
                 IR(KBr) 3434, 2936, 1602, 1565, 1487, 1365, 1242, 1182, 1152, 1123, 1113, 974, 874, 811cm −1   
               
               
                 I-735 
                 mp 168–169° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.38(s, 3H), 3.09(s, 3H), 3.20(s, 3H), 3.81(s, 6H), 5.11(s, 2H), 6.78(s, 2H), 7.13–7.42(m, 9H), 7.66(d, 
               
               
                   
                 J=8.8Hz, 2H) 
               
               
                   
                 IR(KBr) 3433, 1601, 1566, 1486, 1367, 1246, 1182, 1153, 1114, 973, 869, 824cm −1   
               
               
                 I-736 
                 mp 192–194° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.47(s, 6H), 2.72(s, 3H), 3.24(s, 3H), 3.36(s, 3H), 3.57(s, 3H), 3.79(s, 3H), 
               
               
                   
                 4.64(d, J=6.6Hz, 2H), 5.47–5.55(m, 1H), 6.83(s, 1H), 7.09(d, J=9.0Hz, 1H), 7.33–7.40(m, 4H) 
               
               
                   
                 IR(KBr) 3435, 1942, 1516, 1474, 1382, 1357, 1288, 1178, 1096, 966, 862, 805cm −1   
               
               
                 I-737 
                 mp 224–225° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.38(s, 3H), 2.46(s, 6H), 2.66(s, 3H), 3.12(s, 3H), 3.35(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 5.14(s, 2H), 
               
               
                   
                 6.82(s, 1H), 7.12–7.40(m, 9H) 
               
               
                   
                 IR(KBr) 3435, 2941, 1518, 1474, 1360, 1274, 1179, 1095, 1085, 967, 862, 815, 805cm −1   
               
               
                 I-738 
                 mp 203–204° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 2.46(s, 6H), 2.45–2.58(m, 2H), 2.73(s, 3H), 3.22(s, 3H), 3.35(s, 3H), 3.55(s, 
               
               
                   
                 3H), 3.77(s, 3H), 4.07(d, J=6.6Hz, 2H), 5.18–5.25(m, 1H), 6.82(s, 1H), 7.07(d, J=8.2Hz, 1H), 7.32–7.39(m, 4H) 
               
               
                   
                 IR(KBr) 3434, 2941, 1519, 1473, 1359, 1276, 1178, 1114, 1085, 967, 860, 811cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 146 
               
               
                   
               
             
            
               
                 I-739 
                 mp 158–159° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.76(s, 3H), 3.72(s, 6H), 4.54(d, J=6.0Hz, 2H), 5.45–5.52(m, 1H), 6.55–6.59(m, 2H), 
               
               
                   
                 6.84–6.90(m, 5H), 7.57(d, J=8.2Hz, 2H), 8.70(brs, 1H), 9.53(brs, 1H) 
               
               
                   
                 IR(KBr) 3465, 2932, 1610, 1523, 1487, 1460, 1283, 1281, 1123, 1010, 819cm −1   
               
               
                 I-740 
                 mp 180–181° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.32(s, 3H), 3.72(s, 6H), 5.08(s, 2H), 6.54–6.58(m, 1H), 6.68(s, 1H), 6.85–6.95(m, 5H), 7.21(d, J=7.6Hz, 
               
               
                   
                 2H), 7.39(d, J=7.8Hz, 2H), 7.57(d, J=8.4Hz, 2H), 8.83(brs, 1H), 9.54(brs, 1H) 
               
               
                   
                 IR(KBr) 3519, 2937, 1607, 1562, 1523, 1461, 1400, 1246, 1176, 1125, 1003, 821cm −1   
               
               
                 I-741 
                 mp 105–106° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.13(s, 6H), 3.17(s, 3H), 5.16(s, 2H), 5.85(brs, 1H), 6.61–6.66(m, 1H), 6.77(s, 1H), 7.01(d, J=8.2Hz, 
               
               
                   
                 1H), 7.25–7.46(m, 9H), 7.65(d, J=8.8Hz, 2H) 
               
               
                   
                 IR(KBr) 3466, 3031, 2934, 1585, 1513, 1476, 1366, 1285, 1198, 1175, 1148, 1127, 1014, 968, 868, 840cm −1   
               
               
                 I-742 
                 mp 92–93° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.74(s, 3H), 1.78(s, 3H), 2.24(s, 6H), 3.31(s, 3H), 3.65(s, 3H), 4.56(d, J=6.8Hz, 2H), 5.52(t, J=6.0Hz, 
               
               
                   
                 1H), 6.37(s, 1H), 6.64–6.76(m, 2H), 6.88–6.93(m, 1H), 7.16–7.20(m, 2H), 8.31(brs, 1H), 8.45(brs, 1H), 8.73(brs, 
               
               
                   
                 1H) 
               
               
                   
                 IR(KBr) 3443, 2932, 1707, 1613, 1516, 1484, 1462, 1387, 1280, 1243, 1196, 1114, 1074, 979cm −1   
               
               
                 I-743 
                 mp 180–181° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.22(s, 6H), 2.32(s, 3H), 3.29(s, 3H), 3.63(s, 3H), 5.08(s, 2H), 6.61–6.65(m, 1H), 6.75(s, 1H), 6.93 
               
               
                   
                 (d, J=8.2Hz, 1H), 7.13–7.22(m, 4H), 7.39(d, J=7.4Hz, 2H), 8.30(brs, 1H), 8.44(brs, 1H), 8.84(brs, 1H) 
               
               
                   
                 IR(KBr) 3443, 2930, 1686, 1614, 1587, 1518, 14863, 1462, 1385, 1281, 1246, 1197, 1113, 1073, 1009, 806cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 147 
               
               
                   
               
             
            
               
                 I-744 
                 mp 123–124° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.65(s, 3H), 1.71(s, 3H), 2.23(s, 6H), 2.36–2.51(m, 2H), 3.31(s, 3H), 3.64(s, 3H), 3.91–3.98(m, 
               
               
                   
                 2H), 5.22–5.28(m, 1H), 6.36(s, 1H), 6.65–6.88(m, 3H), 7.16(s, 1H), 8.30(brs, 1H), 8.44(brs, 1H), 8.70(brs, 1H) 
               
               
                   
                 IR(KBr) 3444, 2930, 1686, 1613, 1518, 1483, 1390, 1283, 1248, 1198, 1113, 1074, 1013cm −1   
               
               
                 I-745 
                 mp 174–177° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77–1.78(d, J=0.9Hz, 3H), 1.82–1.83(d, J=0.9Hz, 3H), 2.74(s, 3H), 3.18(s, 3H), 3.25(s, 3H), 3.57 
               
               
                   
                 (s, 3H), 3.78(s, 2H), 4.64–4.67(d, J=6.9Hz, 2H), 5.51(m, 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.35–7.40(m, 2H), 
               
               
                   
                 7.45–7.49(m, 2H), 7.55–7.60(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 2939, 1613, 1519, 1480, 1371, 1331, 1292, 1251, 1176, 1150, 1118, 1082, 971, 871, 849cm −1   
               
               
                 I-746 
                 mp 134–136° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.69(s, 3H), 1.75(s, 3H), 2.53–2.60(dt, J=6.6, 5.7Hz, 2H), 2.73(s, 3H), 3.18(s, 3H), 3.23(s, 3H), 3.56 
               
               
                   
                 (s, 3H), 3.78(s, 3H), 4.07–4.11(t, J=5.7Hz, 2H), 5.22(m, 1H), 6.86(s, 1H), 7.07(d, J=9.0Hz, 1H), 7.35–7.40(m, 2H), 
               
               
                   
                 7.45–7.49(m, 2H), 7.55–7.61(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 2938, 1614, 1519, 1480, 1448, 1371, 1331, 1294, 1228, 1176, 1150, 1119, 1083, 1004, 970, 870, 849, 819cm −1   
               
               
                 I-747 
                 mp 182–183° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.26(s, 3H), 2.28(s, 3H), 4.74(s, 1H), 5.16(s, 2H), 5.69(s, 1H), 6.81–6.89(m, 3H), 6.96–6.99(m, 2H), 
               
               
                   
                 7.10–7.12(d, J=4.8Hz, 2H), 7.23–7.26(m, 2H), 7.39–7.45(m, 5H) 
               
               
                   
                 IR(CHCl 3 ) 3597, 3543, 2924, 2871, 1611, 1587, 1522, 1490, 1455, 1382, 1171, 1126, 1012, 836cm −1   
               
               
                 I-748 
                 mp 158–161° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.38(s, 3H), 2.74(s, 3H), 3.12(s, 3H), 3.18(s, 3H), 3.57(s, 3H), 3.78(s, 3H), 5.15(s, 2H), 6.86(s, 1H), 
               
               
                   
                 7.16(d, J=8.7Hz, 1H), 7.21–7.24(d, J=7.8Hz, 1H), 7.35–7.40(m, 5H), 7.45–7.49(m, 2H), 7.52–7.62(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 2939, 1732, 1614, 1519, 1480, 1331, 1294, 1253, 1176, 1150, 1119, 1082, 1003, 970, 869, 816cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 148 
               
               
                   
               
             
            
               
                 I-749 
                 mp 174–176° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.79(s, 3H), 2.58(s, 3H), 3.52(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 4.62(d, J=6.9Hz, 2H), 
               
               
                   
                 5.48–5.55(m, 1H), 6.83(s, 1H), 6.99(d, J=8.7Hz, 1H), 7.09(dd, J=1.8, 8.1Hz, 1H), 7.11–7.19(m, 2H), 7.22(d, J=1.8Hz, 
               
               
                   
                 1H), 7.57–7.65(m, 2H) 
               
               
                   
                 IR(KBr) 2932, 1602, 1519, 1485, 1385, 1368, 1174, 1086, 1015, 986, 848, 804, 527cm −1   
               
               
                 I-750 
                 mp 129–131° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.79(s, 3H), 3.45(s, 3H), 3.53(s, 3H), 3.75(s, 3H), 4.62(d, J=6.6Hz, 2H), 5.24(s, 2H), 
               
               
                   
                 5.50–5.58(m, 1H), 5.90(s, 1H), 6.44(s, 1H), 6.99(d, J=8.7Hz, 1H), 7.08–7.18(m, 3H), 7.29(d, J=1.8Hz, 1H), 7.58–7.64(m, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3361, 2953, 2934, 1522, 1488, 1460, 1391, 1230, 1154, 1121, 1071, 993, 912, 817, 587cm −1   
               
               
                 I-751 
                 mp 148–150° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.68(s, 3H), 1.74(s, 3H), 2.51–2.60(m, 5H), 3.53(s, 6H), 3.77(s, 3H), 4.02(t, J=7.2Hz, 2H), 5.19–5.25 
               
               
                   
                 (m, 3H), 6.83(s, 1H), 6.98(d, J=8.4Hz, 1H), 7.08(dd, J=2.1, 8.4Hz, 1H), 7.11–7.18(m, 2H), 7.21(d, J=2.1Hz, 1H), 
               
               
                   
                 7.57–7.64(m, 2H) 
               
               
                   
                 IR(KBr) 2931, 1603, 1519, 1484, 1386, 1370, 1231, 1175, 1086, 1015, 983, 961, 847, 728, 526cm −1   
               
               
                 I-752 
                 mp 99–101° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.68(s, 3H), 1.73(s, 3H), 2.55(q, J=7.2Hz, 2H), 3.44(s, 3H), 3.54(s, 3H), 3.75(s, 3H), 4.04(t, J=7.2Hz, 
               
               
                   
                 2H), 5.20–5.25(m, 3H), 5.89(s, 1H), 6.44(s, 1H), 6.98(d, J=8.1Hz, 1H), 7.09–7.18(m, 3H), 7.26–7.27(m, 1H), 7.58–7.63 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(KBr) 3349, 2930, 1609, 1523, 1489, 1231, 1152, 1121, 1072, 994, 912, 813, 588cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 149 
               
               
                   
               
             
            
               
                 I-753 
                 mp 115–117° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.69(s, 3H), 1.75(s, 3H), 2.53(q, J=6.9Hz, 2H), 2.62(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.06(t, J=6.9Hz, 
               
               
                   
                 2H), 5.18–5.25(m, 1H), 5.70(s, 1H), 6.83(s, 1H), 6.89–6.95(m, 2H), 7.02(d, J 1.2Hz, 1H), 7.10–7.18(m, 2H), 7.57–7.65 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(KBr) 3545, 2931, 1604, 1520, 1485, 1370, 1249, 1232, 1175, 1084, 1012, 813, 526cm −1   
               
               
                 I-754 
                   1 H NMR(CDCl 3 ) δ 1.14(t, J=6.9Hz, 3H), 1.29(t, J=6.9Hz, 3H), 2.50(s, 3H), 3.19(s, 3H), 3.71(q, J=6.9Hz, 2H), 4.00 
               
               
                   
                 (q, J=6.9Hz, 2H), 5.18(s, 2H), 5.68(s, 1H), 6.83(s, 1H), 6.91(dd, J=1.8, 8.4Hz, 1H), 7.00(d, J=8.4Hz, 1H), 7.04(d, J=1.8Hz, 
               
               
                   
                 1H), 7.32–7.48(m, 7H), 7.66–7.74(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3532, 2976, 1586, 1516, 1468, 1369, 1282, 1174, 1148, 1068, 1016, 967, 907, 871cm −1   
               
               
                 I-755 
                 amorphous powder 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.15(t, J=6.9Hz, 3H), 1.28(t, J=6.9Hz, 3H), 3.59(q, J=6.9Hz, 2H), 3.97(q, J=6.9Hz, 2H), 4.89 
               
               
                   
                 (s, 1H), 5.15(s, 2H), 5.64(s, 1H), 5.98(s, 1H), 6.45(s, 1H), 6.86–6.94(m, 2H), 6.96–7.04(m, 2H), 7.12(d, J=2.4Hz, 1H), 
               
               
                   
                 7.35–7.56(m, 7H), 
               
               
                   
                 IR(CHCl 3 ) 3534, 1610, 1521, 1488, 1383, 1169, 1116, 1064, 1018, 832cm −1   
               
               
                 I-756 
                 mp 126–129° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.14(t, J=6.9Hz, 3H), 1.30(t, J=6.9Hz, 3H), 1.76(s, 3H), 1.81(s, 3H), 2.69(s, 3H), 3.20(s, 3H), 
               
               
                   
                 3.23(s, 3H), 3.72(q, J=6.9Hz, 2H), 4.00(q, J=6.9Hz, 2H), 4.64(d, J=6.6Hz, 2H), 5.49(m, 1H), 6.84(s, 1H), 7.08(d, J=8.7Hz, 
               
               
                   
                 1H), 7.32–7.42(m, 4H), 7.56–7.72(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 1609, 1516, 1467, 1369, 1267, 1229, 1175, 1148, 1115, 1069, 968, 907, 871cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 150 
               
               
                   
               
             
            
               
                 I-757 
                 mp 123–135° C.(dec.) 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.14(t, J=6.9Hz, 3H), 1.29(t, J=6.9Hz, 3H), 2.37(s, 3H), 2.64(s, 3H), 3.12(s, 3H), 3.20(s, 3H), 
               
               
                   
                 3.71(q, J=6.9Hz, 2H), 4.00(q, J=6.9Hz, 2H), 5.14(s, 2H), 6.83(s, 1H), 7.14(d, J=8.7Hz, 1H), 7.18–7.24(m, 2H), 7.31–7.40 
               
               
                   
                 (m, 5H), 7.41(d, J=2.1Hz, 1H), 7.65–7.72(m, 2H) 
               
               
                   
                 IR(CHCl 3 )1607, 1517, 1467, 1369, 1330, 1268, 1175, 1148, 1116, 1069, 1026, 967, 907, 871cm −1   
               
               
                 I-758 
                 amorphous powder 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.15(t, J=6.9Hz, 3H), 1.28(t, J=6.9Hz, 3H), 1.76(s, 3H), 1.82(d, J=0.6Hz, 3H), 3.59(q, J=6.9Hz, 
               
               
                   
                 2H), 3.97(q, J=6.9Hz, 2H), 4.61(d, J=6.9Hz, 2H), 4.87(s, 1H), 5.53(m, 1H), 5.66(s, 1H), 5.97(s, 1H), 6.45(s, 1H), 
               
               
                   
                 6.86–7.00(m, 4H), 7.09(d, J=1.8Hz, 1H), 7.50–7.57(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3528, 2978, 1611, 1521, 1487, 1412, 1383, 1168, 1115, 1064, 905, 831cm −1   
               
               
                 I-759 
                 amorphous powder 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.15(t, J=6.9Hz, 3H), 1.27(t, J=6.9Hz, 3H), 2.39(s, 3H), 3.59(q, J=6.9Hz, 2H), 3.97(q, J=6.9Hz, 
               
               
                   
                 2H), 4.88(s, 1H), 5.10(s, 2H), 5.64(s, 1H), 5.97(s, 1H), 6.45(s, 1H), 6.97–7.01(m, 2H), 7.11(d, J=1.5Hz, 1H), 7.20–7.26 
               
               
                   
                 (m, 2H), 7.32–7.37(m, 2H), 7.50–7.56(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3526, 2974, 1612, 1520, 1488, 1412, 1383, 1285, 1246, 1116, 1065, 1027, 870cm −1   
               
               
                 I-760 
                 mp 169–171° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.71(s, 3H), 3.01(s, 3H), 3.10(s, 3H), 3.21(s, 3H), 3.36(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 4.83(s, 
               
               
                   
                 2H), 6.84(s, 1H), 7.05(d, J=8.4Hz, 1H), 7.32(dd, J=2.1, 8.4Hz, 1H), 7.36–7.42(m, 2H), 7.42(d, J=2.1Hz, 1H), 7.65–7.72 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(CHCl 3 )1666, 1517, 1479, 1368, 1175, 1148, 1119, 1083, 1014, 968, 871cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 151 
               
               
                   
               
             
            
               
                 I-761 
                 mp 175–177° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.70(s, 6H), 3.67–3.73(m, 2H), 3.71(s, 3H), 3.72(s, 3H), 4.59(br, 1H), 5.27–5.31(m, 1H), 6.50(d, 
               
               
                   
                 J=8.1Hz, 1H), 6.77–6.95(m, 6H), 7.34–7.40(m, 2H), 9.23(br s, 1H), 9.42(br s, 1H) 
               
               
                   
                 IR(KBr)3600–2400(br), 1609, 1522, 1492, 1463, 1384, 1263, 1208, 1174, 1129, 1055, 1033cm −1   
               
               
                 I-762 
                 mp 151–153° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.78(s, 3H), 1.85(s, 3H), 3.78(s, 3H), 3.80(s, 3H), 4.72(d, J=6.9Hz, 2H), 5.39–5.44(m, 1H), 6.53(d, 
               
               
                   
                 J=3.0Hz, 1H), 6.95(s, 1H), 7.05(s, 1H), 7.09–7.16(m, 3H), 7.38(d, J=8.7Hz, 1H), 7.45(dd, J=1.8, 8.7Hz, 1H), 7.54–7.60 
               
               
                   
                 (m, 2H), 7.80(d, J=1.8Hz, 1H), 
               
               
                   
                 IR(KBr)3600–2800(br), 1509, 1496, 1481, 1462, 1447, 1383, 1207, 1158, 1051cm −1   
               
               
                 I-763 
                 mp 138–139° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.78(s, 3H), 3.79(s, 3H), 6.64(dd, J=0.9, 2.7Hz, 1H), 6.80(d, J=7.8Hz, 1H), 6.94(s, 1H), 7.04(s, 
               
               
                   
                 1H), 7.09–7.21(m, 3H), 7.25–7.27(m, 1H), 7.32(d, J=8.7Hz, 1H), 7.42(dd, J=1.8, 8.4Hz, 1H), 7.53–7.59(m, 3H), 8.60–8.63 
               
               
                   
                 (m, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1590, 1510, 1497, 1478, 1430, 1384, 1209, 1158, 1053, 1026cm −1   
               
               
                 I-764 
                 mp 172–174° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.32(s, 3H), 3.78(s, 3H), 3.79(s, 3H), 5.30(s, 2H), 6.59(d, J=3.3Hz, 1H), 6.94(s, 1H), 7.04(s, 1H), 
               
               
                   
                 7.04–7.15(m, 7H), 7.34(d, J=8.4Hz, 1H), 7.41(dd, J=1.8, 8.7Hz, 1H), 7.55–7.59(m, 2H), 7.82–7.83(m, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1516, 1497, 1482, 1466, 1382, 1306, 1219, 1209, 1159, 1051, 1026cm −1   
               
               
                 I-765 
                 mp 134–136° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.70(s, 3H), 1.71(s, 3H), 3.72–3.74(m, 2H), 3.73(s, 3H), 3.74(s, 3H), 5.25(br s, 1H), 5.50–5.58(m, 
               
               
                   
                 1H), 6.66–6.72(m, 1H), 6.78–6.83(m, 1H), 6.92(s, 3H), 6.95(s, 3H), 7.19–7.29(m, 2H), 7.30–7.39(m, 2H), 9.45(br s, 3H), 
               
               
                   
                 IR(KBr)3600–2800(br), 1624, 1610, 1526, 1494, 1461, 1382, 1255, 1208, 1175, 1120, 1054, 1031cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 152 
               
               
                   
               
             
            
               
                 I-766 
                 mp 166–168° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.40(s, 3H), 3.77(s, 6H), 4.82(s, 1H), 6.71(d, J=2.4Hz, 1H), 6.86–6.93(m, 4H), 7.22–7.32(m, 4H), 
               
               
                   
                 7.43–7.48(m, 2H), 7.58–7.64(m, 1H), 7.71–7.75(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1611, 1524, 1492, 1382, 1336, 1265, 1209, 1162, 1090, 1053, 1030cm −1   
               
               
                 I-767 
                 mp 139–140° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.78(s, 3H), 3.80(s, 3H), 6.60–6.62(m, 1H), 6.95(s, 1H), 7.05(s, 1H), m), 7.08–7.16(m, 2H), 7.23–7.26 
               
               
                   
                 (m, 1H), 7.45(d, J=1.2Hz, 2H), 7.54–7.61(m, 2H), 7.83(d, J=0.6Hz, 1H), 8.18(br s, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1520, 1497, 1465, 1448, 1414, 1383, 1313, 1218, 1205, 1159, 1048, 1024cm −1   
               
               
                 I-768 
                   1 H NMR(CDCl 3 ) δ 2.26(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 5.16(s, 2H), 5.69(s, 1H), 5.89(s, 1H), 6.45(s, 1H), 6.94(d.d, J=8.4 
               
               
                   
                 &amp; 2.1Hz, 1H), 7.02(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.35–7.50(m, 8H), 8.36–8.44(m, 1H) 
               
               
                   
                 IR(KBr)3384, 1592, 1525, 1487, 1455, 1397, 1312, 1250, 1122, 1102, 1069, 1011cm −1   
               
               
                 I-769 
                   1 H NMR(CDCl 3 ) δ 2.26(s, 3H), 2.68(s, 3H), 3.13(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 7.15(d, J=8.4Hz, 
               
               
                   
                 1H), 7.30–7.51(m, 10H), 8.37–8.47(m, 1H) 
               
               
                   
                 IR(KBr)3384, 1704, 1590, 1524, 1481, 1389, 1357, 1272, 1240, 1174, 1114, 1082, 1017cm −1   
               
               
                 I-770 
                   1 H NMR(CDCl 3 ) δ 2.67(s, 3H), 2.84(s, 3H), 3.28(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 6.26(s, 1H), 6.85(s, 1H), 7.17(d, J=9.0Hz, 
               
               
                   
                 1H), 7.24–7.33(m, 2H), 7.35–7.50(m, 3H), 8.37–8.50(m, 1H) 
               
               
                   
                 IR(KBr)3383, 1674, 1595, 1526, 1482, 1363, 1177, 1078, 1012cm −1   
               
               
                 I-771 
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.26(s, 3H), 2.72(s, 3H), 3.23(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.64(d, J=7.2Hz, 
               
               
                   
                 2H), 5.44–5.53(m, 1H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.30–7.53(m, 5H), 8.38–8.47(m, 1H) 
               
               
                   
                 IR(KBr)3376, 1697, 1594, 1524, 1481, 1365, 1270, 1239, 1177, 1112, 1079, 1013cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 153 
               
               
                   
               
             
            
               
                 I-772 
                   1 H NMR(CDCl 3 ) δ 2.26(s, 3H), 2.38(s, 3H), 2.68(s, 3H), 3.12(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.14(s, 2H), 6.84(s, 1H), 
               
               
                   
                 7.12–7.50(m, 9H), 8.35–8.44(m, 1H) 
               
               
                   
                 IR(KBr)3365, 1693, 1622, 1591, 1526, 1477, 1374, 1314, 1291, 1180, 1165, 1111, 1078cm −1   
               
               
                 I-773 
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 2.26(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.46–5.58 
               
               
                   
                 (m, 1H), 5.71(s, 1H), 5.86(s, 1H), 6.44(s, 1H), 6.87–7.00(m, 2H), 7.05(.d, J=1.8Hz, 1H), 7.33–7.52(m, 3H), 8.36–8.47 
               
               
                   
                 (m, 1H) 
               
               
                   
                 IR(KBr)1737, 1604, 1519, 1482, 1392, 1366, 1267, 1173, 1131, 1084, 1062, 1009cm −1   
               
               
                 I-774 
                   1 H NMR(CDCl 3 ) δ: 2.25(s, 3H), 2.38(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 5.10(s, 2H), 5.12(brs, 1H), 5.90(s, 1H), 6.44(s, 
               
               
                   
                 1H), 6.94(.d.d, J=8.4 &amp; 1.8Hz, 1H), 7.02(.d, J=8.4Hz, 1H), 7.06(.d, J=1.8Hz, 1H), 7.18–7.52(m, 6H), 8.35–8.44(m, 
               
               
                   
                 1H) 
               
               
                   
                 IR(KBr)1686, 1590, 1524, 1488, 1398, 1314, 1257, 1102, 1068, 1008cm −1   
               
               
                 I-775 
                   1 H NMR(CDCl 3 ) δ 3.47(s, 3H), 3.76(s, 3H), 5.16(s, 2H), 5.71(s, 1H), 5.82(s, 1H), 6.45(s, 1H), 6.97(d.d, J=8.4 &amp; 2.1Hz, 
               
               
                   
                 1H), 7.04(d, J=8.4Hz, 1H), 7.07(d, J=2.1Hz, 1H), 7.22–7.30(m, 1H), 7.33–7.49(m, 5H), 7.92–7.98(m, 1H), 8.09–8.14 
               
               
                   
                 (m, 1H), 10.44(s, 1H) 
               
               
                   
                 IR(KBr)3492, 3459, 1692, 1605, 1518, 1486, 1388, 1294, 1238, 1200, 1115, 1100, 1070, 1008cm −1   
               
               
                 I-776 
                   1 H NMR(CDCl 3 ) δ 2.35(d, J=1.8Hz, 3H), 2.68(s, 3H), 3.13(s, 3H), 3.23(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.82(s, 1H), 
               
               
                   
                 7.04–7.17(m, 2H), 7.30–7.49(m, 9H) 
               
               
                   
                 IR(KBr)1606, 1518, 1478, 1364, 1295, 1271, 1240, 1182, 1118, 1087, 1077, 1017cm −1   
               
               
                 I-777 
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.35(s, 3H), 2.72(s, 3H), 3.23(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 
               
               
                   
                 2H), 5.45–5.53(m, 1H), 6.82(s, 1H), 7.03–7.14(m, 2H), 7.32–7.47(m, 4H) 
               
               
                   
                 IR(KBr)1607, 1520, 1482, 1374, 1363, 1240, 1179, 1115, 1079cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 154 
               
               
                   
               
             
            
               
                 I-778 
                   1 H NMR(CDCl 3 ) δ 2.35(d, J=1.2Hz, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 5.90(s, 1H), 6.43(s, 1H), 
               
               
                   
                 6.92–7.12(m, 4H), 7.31–7.50(m, 7H) 
               
               
                   
                 IR(KBr)3536, 3398, 1609, 1587, 1518, 1487, 1244, 1192, 1110, 1071, 1010cm −1   
               
               
                 I-779 
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 2.35(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.61(d, J=6.9Hz, 2H), 5.43–5.60(m, 
               
               
                   
                 1H), 6.43(s, 1H), 6.87–7.15(m, 4H), 7.36–7.51(m, 2H) 
               
               
                   
                 IR(KBr)3512, 3444, 1611, 1585, 1518, 1488, 1462, 1447, 1416, 1305, 1288, 1243, 1207, 
               
               
                   
                 1112, 1103, 1070, 1012cm −1   
               
               
                 I-780 
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 4.84(s, 2H), 5.15(s, 2H), 5.70(s, 1H), 5.88(s, 1H), 6.44(s, 1H), 6.91–7.20(m, 
               
               
                   
                 4H), 7.32–7.48(m, 5H), 7.52–7.61(m, 1H), 7.64–7.74(m, 1H) 
               
               
                   
                 IR(KBr)3523, 3428, 1610, 1587, 1516, 1482, 1463, 1400, 1321, 1285, 1238, 1187, 
               
               
                   
                 1106cm −1   
               
               
                 I-781 
                   1 H NMR(CDCl 3 ) δ 2.68(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 5.44(d.d, J=18 &amp; 0.6Hz, 1H), 5.90 
               
               
                   
                 (d.d, J=18 &amp; 0.9Hz, 1H), 6.84(s, 1H), 6.86–6.98(m, 1H), 7.09–7.18(m, 2H), 7.31–7.52(m, 8H), 7.71(d.d, J=7.2 &amp; 2.4Hz, 
               
               
                   
                 1H) 
               
               
                   
                 IR(KBr)1608, 1518, 1479, 1365, 1235, 1177, 1118, 1079, 1013cm −1   
               
               
                 I-782 
                   1 H NMR(CDCl 3 ) δ 1.59(d, J=6.3Hz, 3H), 2.68(s, 3H), 3.13(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 5.21–5.30(m, 
               
               
                   
                 1H), 6.84(s, 1H), 7.08–7.17(m, 3H), 7.32–7.56(m, 7H), 7.69–7.75(m, 1H) 
               
               
                   
                 IR(KBr)3543, 3433, 1609, 1518, 1480, 1364, 1235, 1178, 1117, 1078, 1014cm −1   
               
               
                 I-783 
                   1 H NMR(CDCl 3 ) δ 1.59(d, J=6.0Hz, 3H), 2.01(brs, 1H), 3.47(s, 3H), 3.76(s, 3H), 5.16(s, 2H), 5.15–5.30(m, 1H), 5.72 
               
               
                   
                 (s, 1H), 5.91(s, 1H), 6.46(s, 1H), 6.89–7.16(m, 4H), 7.30–7.60(m, 6H), 7.68–7.85(m, 1H) 
               
               
                   
                 IR(KBr)3467, 1613, 1586, 1517, 1484, 1455, 1421, 1395, 1287, 1238, 1111, 1070, 1010cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 155 
               
               
                   
               
             
            
               
                 I-784 
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 3.23(s, 3H), 3.81(s, 6H), 4.64(d, J=6.6Hz, 2H), 5.47–5.54(m, 1H), 6.91(s, 
               
               
                   
                 1H), 6.96(s, 1H), 7.06(d, J=8.4Hz, 1H), 7.49(d.d, J=8.4 &amp; 2.1Hz, 1H), 7.58(d, J=2.1Hz, 1H), 7.60–7.74(m, 4H) 
               
               
                   
                 IR(KBr)2228, 1610, 1490, 1348, 1295, 1266, 1209, 1174, 1112, 1056, 
               
               
                   
                 1038, 1000cm −1   
               
               
                 I-785 
                 mp 169–170° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.07(s, 6H), 3.20(s, 3H), 5.16(s, 2H), 5.71(brs, 1H), 6.97–7.45(m, 14H) 
               
               
                   
                 IR(KBr)3357, 3023, 2933, 1698, 1516, 1478, 1362, 1260, 1227, 1152, 1132, 962, 869cm −1   
               
               
                 I-786 
                 mp 169–170° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.13(s, 6H), 3.11(s, 3H), 3.18(s, 3H), 5.18(s, 2H), 7.09–7.47(m, 12H), 7.64(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3434, 3035, 2938, 1516, 1474, 1362, 1290, 1197, 1182, 1174, 1149, 1114, 973, 857, 842cm −1   
               
               
                 I-787 
                 mp 156–157° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.08(s, 6H), 3.12(s, 3H), 3.21(s, 3H), 5.18(s, 2H), 7.12–7.58(m, 14H) 
               
               
                   
                 IR(KBr)3494, 3292, 3033, 2934, 1753, 1712, 1517, 1478, 1358, 1294, 1261, 1173, 1151, 967, 870cm −1   
               
               
                 I-788 
                 mp 105–106° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.85(s, 3H), 2.12(s, 6H), 3.18(s, 3H), 3.22(s, 3H), 4.64(d, J=7.0Hz, 2H), 5.52(t, J=6.8Hz, 
               
               
                   
                 1H), 7.08(s, 1H), 7.16–7.38(m, 6H), 7.64(d, J=8.8Hz, 2H) 
               
               
                   
                 IR(KBr)3434, 2934, 1514, 1474, 1362, 1285, 1152, 1113, 971, 916, 861, 845cm −1   
               
               
                 I-789 
                 mp 148–149° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.12(s, 6H), 2.39(s, 3H), 3.10(s, 3H), 3.18(s, 3H), 5.13(s, 2H), 7.10–7.38(m, 11H), 7.64(d, J=8.6Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr)3435, 3027, 2931, 1678, 1516, 1475, 1362, 1288, 1182, 1151, 1113, 969, 916, 861cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 156 
               
               
                   
               
             
            
               
                 I-790 
                 mp 139–140° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 2.14(s, 6H), 2.46–2.58(m, 2H), 3.14(s, 3H), 3.19(s, 3H), 4.07(d, J=7.0Hz, 
               
               
                   
                 2H), 5.16–5.23(m, 1H), 7.05(s, 1H), 7.14–7.41(m, 6H), 7.66(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3433, 2946, 1514, 1467, 1360, 1282, 1180, 1152, 1115, 868cm −1   
               
               
                 I-791 
                 mp 123–124° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.77(s, 3H), 2.03(s, 6H), 4.56(d, J=6.6Hz, 2H), 5.50(t, J=6.0Hz, 1H), 6.49(d, J=9.6Hz, 
               
               
                   
                 1H), 6.55(s, 1H), 6.83(d, J=8.4Hz, 2H), 6.98(d, J=8.1Hz, 1H), 7.27(s, 2H), 7.48(d, J=5.6Hz, 2H), 8.92(brs, 
               
               
                   
                 1H), 9.48(brs, 1H) 
               
               
                   
                 IR(KBr)3337, 2930, 1612, 1518, 1471, 1285, 1258, 1207, 1123, 999, 834cm −1   
               
               
                 I-792 
                 mp 230–231° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.04(s, 6H), 2.33(s, 3H), 5.09(s, 2H), 6.50(d, J=8.4Hz, 1H), 6.59(s, 1H), 6.85(d, J=8.1Hz, 2H), 
               
               
                   
                 7.04(d, J=5.4Hz, 1H), 7.23(d, J=7.5Hz, 2H), 7.29(s, 1H), 7.41(d, J=7.8Hz, 2H), 7.49(d, J=8.7Hz, 2H), 9.05(brs, 
               
               
                   
                 1H), 9.50(brs, 1H) 
               
               
                   
                 IR(KBr)3287, 1609, 1519, 1475, 1298, 1245, 1126, 1006, 841cm −1   
               
               
                 I-793 
                 mp 118–119° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.64(s, 3H), 1.70(s, 3H), 2.03(s, 6H), 2.42–2.50(m, 2H), 3.96(t, J=6.9Hz, 2H), 5.27(t, J=7.2Hz, 
               
               
                   
                 2H), 6.49(d, J=8.1Hz, 1H), 6.55(s, 1H), 6.84(d, J=8.4Hz, 2H), 6.96(d, J=8.1Hz, 1H), 7.27(s, 2H), 7.48(d, J=8.7Hz, 
               
               
                   
                 2H), 8.89(brs, 1H), 9.48(brs, 1H) 
               
               
                   
                 IR(KBr)3392, 2928, 1610, 1519, 1466, 1250, 1230, 1205, 1178, 1128, 1031, 834, 808cm −1   
               
               
                 I-794 
                 mp 139–140° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.75(s, 3H), 1.77(s, 3H), 2.50(s, 6H), 3.39(s, 3H), 3.44(s, 3H), 4.69(d, J=6.2Hz, 2H), 5.50(t, J=6.6Hz, 
               
               
                   
                 1H), 7.29–7.33(m, 3H), 7.41–7.47(m, 4H), 7.59–7.68(m, 2H) 
               
               
                   
                 IR(KBr)3433, 2933, 1675, 1516, 1473, 1366, 1358, 1292, 1259, 1182, 1172, 1151, 969, 873cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 157 
               
               
                   
               
             
            
               
                 I-795 
                 mp 151–152° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.05(s, 6H), 2.18(s, 3H), 3.36(s, 3h), 3.44(s, 3H), 5.22(s, 2H), 7.08–7.63(m, 13H) 
               
               
                   
                 IR(KBr)3434, 3023, 2928, 1517, 1477, 1368, 1293, 1261, 1183, 1152, 966, 870cm −1   
               
               
                 I-796 
                 mp 159–160° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.65(s, 3H), 1.70(s, 3H), 2.05(s, 6H), 2.48–2.53(m, 2H), 3.38(s, 3H), 3.44(s, 3H), 4.10(t, J=7.4Hz, 
               
               
                   
                 2H), 5.21–5.27(m, 1H), 7.28–7.34(m, 3H), 7.41–7.47(m, 4H), 7.59–7.64(m, 2H) 
               
               
                   
                 IR(KBr)3434, 2938, 1519, 1478, 1439, 1362, 1295, 1269, 1173, 1152, 1125, 960, 870, 839cm −1   
               
               
                 I-797 
                 mp 130–131° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.75(s, 3H), 2.02(s, 6H), 4.59(d, J=6.4Hz, 2H), 5.48(t, J=7.2Hz, 1H), 6.81–7.07 
               
               
                   
                 (m, 7H), 7.25(s, 2H), 8.96(brs, 1H), 9.41(brs, 1H) 
               
               
                   
                 IR(KBr)3392, 1608, 1589, 1518, 1475, 1322, 1258, 1170, 1127, 974, 836, 808cm −1   
               
               
                 I-798 
                 mp 143–144° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.03(s, 6H), 2.32(s, 3H), 5.12(s, 2H), 6.82–7.41(m, 13H), 9.10(brs, 1H), 9.41(brs, 1H) 
               
               
                   
                 IR(KBr)3344, 1609, 1521, 1427, 1255, 1236, 1205, 1129, 998, 832, 806, 792cm −1   
               
               
                 I-799 
                 mp 163–164° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.87(s, 3H), 1.90(s, 3H), 3.42(s, 3H), 5.15(s, 2H), 6.88–7.03(m, 4H), 7.24–7.58(m, 9H), 7.97(brs, 
               
               
                   
                 1H), 9.02(brs, 1H) 
               
               
                   
                 IR(KBr)3563, 3476, 3001, 2922, 1698, 1527, 1512, 1476, 1359, 1303, 1261, 1237, 1210, 1195, 1167, 1146, 871cm −1   
               
               
                 I-800 
                   1 H NMR(CDCl 3 ) δ 1.30(d, J=6.6Hz, 6H), 2.58(s, 3H), 2.97(quintet, J=6.6Hz, 1H), 3.54(s, 3H), 3.77(s, 3H), 5.17(s, 
               
               
                   
                 2H), 6.87(s, 1H), 7.11(d, J=9.0Hz, 1H), 7.22–7.35(m, 8H), 7.47–7.68(m, 6H), 8.19–8.25(m, 2H) 
               
               
                   
                 IR(KBr)1737, 1604, 1519, 1482, 1392, 1366, 1267, 1173, 1131, 1084, 1062, 1009cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 158 
               
               
                   
               
             
            
               
                 I-801 
                   1 H NMR(CDCl 3 ) δ 2.56(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.17(s, 2H), 5.69(s, 1H), 6.84(s, 1H), 6.91(d.d, J=8.4 &amp; 1.8Hz, 
               
               
                   
                 1H), 7.02(d, J=8.4Hz, 1H), 7.04(d, J=1.8Hz, 1H), 7.04–7.14(m, 1H), 7.33–7.47(m, 8H) 
               
               
                   
                 IR(KBr)3446, 1613, 1585, 1522, 1477, 1396, 1357, 1291, 1243, 1204, 1174, 1076, 1017, 1006cm −1   
               
               
                 I-802 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.82(s, 3H), 3.22(s, 3H), 3.25(s, 3H), 3.26(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.48(s, 2H), 6.85(s, 1H), 
               
               
                   
                 7.27(d, J=8.4Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.40(dd, J=8.4, 2.1Hz, 1H), 7.43(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(Nujol)1608, 1519, 1480, 1462, 1365, 1176, 1151, 1079, 970, 876, 798cm −1   
               
               
                 I-803 
                 foam 
               
               
                   
                   1 H NMR(CD3OD) δ 3.28(s, 3H), 3.68(s, 3H), 5.17(s, 2H), 6.43(s, 1H), 6.81(dd, J=8.4, 2.1Hz, 1H), 6.85(d, J=8.7Hz, 
               
               
                   
                 2H), 6.89(d, J=2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3342, 1611, 1592, 1523, 1488, 1460, 1251, 1225, 1114, 1072, 1012, 941, 826, 756cm −1   
               
               
                 I-804 
                 mp 150–152° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 3.31(s, 3H), 3.64(s, 3H), 5.00(s, 2H), 6.39(s, 1H), 6.66(dd, J=8.4, 2.1Hz, 1H), 6.79(d, J=2.1Hz, 
               
               
                   
                 1H), 6.84(d, J=8.7Hz, 2H), 6.98(d, J=8.4Hz, 1H), 7.44(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3459, 3291, 1612, 1594, 1522, 1489, 1458, 1257, 1226, 1101, 1073, 1011, 960, 823cm −1   
               
               
                 I-805 
                 mp 190–192° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.88(s, 3H), 3.41(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.79(s, 3H), 5.43(s, 2H), 7.08(s, 1H), 7.16(s, 
               
               
                   
                 1H), 7.32–7.36(m, 2H), 7.46(d, J=8.4Hz, 1H), 7.49(d, J=8.7Hz, 2H), 7.53–7.64(m, 3H), 7.74(d, J=8.7Hz, 2H), 7.88–7.91 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(Nujol)1604, 1519, 1481, 1462, 1367, 1175, 1081, 1009, 878, 841, 816, 801cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 159 
               
               
                   
               
             
            
               
                 I-806 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.74(s, 3H), 5.31(s, 2H), 6.94(s, 1H), 6.45(s, 1H), 6.64(s, 1H), 6.93(d, J=8.7Hz, 2H), 
               
               
                   
                 6.98(dd, J=8.4, 2.1Hz, 1H), 7.09(d, J=8.4Hz, 1H), 7.11(d, J=2.1Hz, 1H), 7.46–7.50(m, 3H), 7.53(d, J=8.7Hz, 2H), 
               
               
                   
                 7.78–7.82(m, 2H) 
               
               
                   
                 IR(Nujol)3367, 1612, 1592, 1523, 1489, 1455, 1253, 1226, 1115, 1073, 1013, 942, 816, 767cm −1   
               
               
                 I-807 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.76(s, 3H), 3.21(s, 3H), 3.30(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.38(s, 2H), 6.84(s, 1H), 7.21(d, J=8.4Hz, 
               
               
                   
                 1H), 7.38(d, J=8.7Hz, 2H), 7.38(dd, J=8.4, 2.1Hz, 1H), 7.45(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H), 8.80(s, 
               
               
                   
                 1H) 
               
               
                   
                 IR(Nujol)1608, 1519, 1480, 1463, 1365, 1177, 1151, 1079, 971, 876, 798cm −1   
               
               
                 I-808 
                 mp 193–195° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.64(s, 3H), 2.74(s, 3H), 3.21(s, 3H), 3.30(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.28(s, 2H), 6.84(s, 1H), 
               
               
                   
                 7.21(d, J=8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.38(dd, J=8.4, 2.1Hz, 1H), 7.44(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(Nujol)1606, 1591, 1522, 1480, 1463, 1359, 1174, 1152, 1079, 1012, 946, 877, 834, 796cm −1   
               
               
                 I-809 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.42(t, J=7.5Hz, 3H), 2.73(s, 3H), 2.96(q, J=7.5Hz, 2H), 3.21(s, 3H), 3.31(s, 3H), 3.56(s, 3H), 
               
               
                   
                 3.78(s, 3H), 5.28(s, 2H), 6.84(s, 1H), 7.21(d, J=8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.38(dd, J=8.4, 2.1Hz, 1H), 7.44 
               
               
                   
                 (d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3434, 1609, 1579, 1519, 1481, 1365, 1177, 1151, 1080, 970, 876, 797cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 160 
               
               
                   
               
             
            
               
                 I-810 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.71(s, 3H), 3.21(s, 3H), 3.35(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.38(s, 2H), 6.84(s, 1H), 7.25(d, J=8.4Hz, 
               
               
                   
                 1H), 7.38(d, J=8.7Hz, 2H), 7.40(dd, J=8.4, 2.1Hz, 1H), 7.46(d, J=2.1Hz, 1H), 7.54–7.64(m, 3H), 7.68(d, J=8.7Hz, 
               
               
                   
                 2H), 8.12–8.16(m, 2H) 
               
               
                   
                 IR(KBr) 3433, 1609, 1561, 1519, 1480, 1365, 1177, 1151, 1081, 971, 876, 798cm −1   
               
               
                 I-811 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.51(s, 3H), 2.54(s, 3H), 2.63(s, 3H), 2.72(s, 3H), 3.16(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 
               
               
                   
                 5.27(s, 2H), 6.84(s, 1H), 7.27(d, J=8.4Hz, 1H), 7.36(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 
               
               
                   
                 1H), 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3435, 1614, 1519, 1480, 1364, 1177, 1151, 1080, 972, 876, 798cm −1   
               
               
                 I-812 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.74(s, 6H), 3.17(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.35(s, 2H), 6.84(s, 1H), 7.28(d, J=8.4Hz, 
               
               
                   
                 1H), 7.36(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 8.41(d, 
               
               
                   
                 J=2.4Hz, 1H), 8.50(d, J=2.4Hz, 1H) 
               
               
                   
                 IR(KBr) 3433, 1609, 1519, 1481, 1364, 1177, 1151, 1080, 971, 876, 798cm −1   
               
               
                 I-813 
                 foam 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.47(s, 6H), 2.55(s, 3H), 3.30(s, 3H), 3.64(s, 3H), 5.16(s, 2H), 6.39(s, 1H), 6.66(dd, J=8.4, 2.1Hz, 
               
               
                   
                 1H), 6.76(d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 7.03(d, J=8.4Hz, 1H), 7.44(d, J=8.7Hz, 2H), 
               
               
                   
                 IR(KBr) 3399, 3165, 1611, 1521, 1488, 1406, 1362, 1213, 1114, 1069, 1014, 818, 759cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 161 
               
               
                   
               
             
            
               
                 I-814 
                 mp 240–241° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.66(s, 3H), 3.30(s, 3H), 3.64(s, 3H), 5.26(s, 2H), 6.39(s, 1H), 6.66(dd, J=8.4, 2.1Hz, 1H), 6.77 
               
               
                   
                 (d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 7.02(d, J=8.4Hz, 1H), 7.44(d, J=8.7Hz, 2H), 8.48(d, J=2.7Hz, 1H), 8.53(d, 
               
               
                   
                 J=2.7Hz, 1H) 
               
               
                   
                 IR(Nujol) 3513, 3491, 3070, 1610, 1581, 1523, 1488, 1459, 1408, 1275, 1236, 1216, 1111, 1065, 1040, 821, 785cm −1   
               
               
                 I-815 
                 mp 288–290° C.(decomp.) 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.89(s, 3H), 3.41(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.79(s, 3H), 4.95(s, 2H), 5.65(s, 1H), 7.08(s, 
               
               
                   
                 1H), 7.26(d, J=8.4Hz, 1H), 7.33(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=2.1Hz, 1H), 7.49(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 
               
               
                   
                 2H), 
               
               
                   
                 IR(Nujol) 3120, 1712, 1671, 1604, 1516, 1480, 1462, 1364, 1172, 1078, 1015, 970, 874, 841, 796cm −1   
               
               
                 I-816 
                 mp 204–206° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.87(s, 3H), 3.45(s, 3H), 3.46(s, 3H), 3.52(s, 3H), 3.78(s, 3H), 5.40(s, 2H), 7.08(s, 1H), 7.32(dd, 
               
               
                   
                 J=8.4, 2.1Hz, 1H), 7.33(d, J=8.4Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.48(d, J=8.7Hz, 2H), 7.71(dd, J=5.1, 1.2Hz, 1H), 
               
               
                   
                 7.74(d, J=8.7Hz, 2H), 8.88(d, J=5.1Hz, 1H), 9.21(d, J=1.2Hz, 1H) 
               
               
                   
                 IR(Nujol) 1608, 1586, 1557, 1521, 1480, 1464, 1360, 1352, 1176, 1156, 1078, 884, 835, 818, 799cm −1   
               
               
                 I-817 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.20(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.94(dd, J=1.8, 
               
               
                   
                 84Hz, 1H), 6.98(d, J=8.4Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.18(m, 1H), 7.37(t, J=7.2Hz, 1H), 7.53(d, J=8.7Hz, 
               
               
                   
                 2H), 7.55(m, 2H) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 162 
               
               
                   
               
             
            
               
                 I-818 
                 m.p 163–166° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.53(s, 9H), 2.67(s, 3H), 3.11(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 5.12(s, 2H), 6.52(s, 1H), 
               
               
                   
                 6.84(s, 1H), 7.13(d, J=8.4Hz, 1H), 7.33(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.39(m, 5H), 7.74(d, J=8.7Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 1692, 1614, 1520, 1480, 1390, 1367, 1231, 1175, 1152, 1078, 876, 799cm −1   
               
               
                 I-819 
                 m.p 172° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.77(s, 3H), 3.05(s, 3H), 3.16(s, 3H), 3.22(s, 3H), 3.36(s, 3H), 3.78(s, 3H), 5.16(s, 2H), 6.46(s, 1H), 
               
               
                   
                 6.85(s, 1H), 7.14(d, J=8.4Hz, 1H), 7.25(d, J=8.7Hz, 2H), 7.35(dd, J=2.1, 8.4Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.40(d, 
               
               
                   
                 J=2.1, 1H), 7.47(d, J=8.4Hz, 2H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1608, 1519, 1480, 1361, 1175, 1154, 1079, 972, 876, 801cm −1   
               
               
                 I-820 
                 mp 180–182° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.69(s, 3H), 3.14(s, 3H), 3.21(s, 3H), 3.53(s, 3H), 3.71(d, J=0.9Hz, 3H), 5.20(s, 2H), 6.93(d, J=8.4Hz, 
               
               
                   
                 1H), 7.34–7.49(m, 9H), 7.59(dd, J=9.0, 1.2Hz, 2H) 
               
               
                   
                 IR(KBr) 1518, 1469, 1357, 1179, 1151, 1038, 871, 821cm −1   
               
               
                 I-821 
                 mp 183–185° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.41(s, 3H), 3.66(d, J=0.9Hz, 3H), 4.91(s, 1H), 5.17(s, 2H), 5.62(s, 1H), 5.70(s, 1H), 6.92–6.96(m, 
               
               
                   
                 2H), 6.97(dd, J=8.4, 2.0Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.10(d, J=2.0Hz, 1H), 7.36–7.48(m, 7H) 
               
               
                   
                 IR(KBr) 3541, 3398, 1588, 1523, 1461, 1410, 1320, 1261, 1217, 1037, 836, 747cm −1   
               
               
                 I-822 
                 mp 108–110° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.69(s, 3H), 3.13(s, 3H), 3.45(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.66(s, 2H), 4.76(s, 2H), 5.19(s, 2H), 
               
               
                   
                 6.86(s, 1H), 7.71(d, J=8.4Hz, 1H), 7.33–7.48(m, 9H), 7.62(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 1482, 1390, 1307, 1276, 1177, 1083, 1053, 1013, 807cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 163 
               
               
                   
               
             
            
               
                 I-823 
                 mp 192–194° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.70(br s, 1H), 2.69(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.78(s, 2H), 5.19(s, 2H), 6.87(s, 
               
               
                   
                 1H), 7.15(d, J=8.4Hz, 1H), 7.35(dd, J=8.4, 2.3Hz, 1H), 7.37–7.49(m, 8H), 7.63(d, J=7.8Hz, 2H) 
               
               
                   
                 IR(KBr) 3554, 3434, 1522, 1481, 1389, 1364, 1277, 1234, 1174, 1085, 1012, 807cm −1   
               
               
                 I-824 
                 mp 135–137° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.19(s, 3H), 3.60(s, 3H), 3.71(s, 3H), 4.96(s, 1H), 5.18(s, 2H), 5.78(s, 1H), 6.73(s, 1H), 6.88(dd, J=8.3, 
               
               
                   
                 2.1Hz, 1H), 7.02(d, J=2.1Hz, 1H), 7.08(d, J=8.3Hz, 1H), 7.34(d, J=8.6Hz, 2H), 7.41–7.47(m, 5H), 7.63(d, J=8.6Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3479, 1473, 1347, 1149, 1010, 869, 803, 784, 747cm −1   
               
               
                 I-825 
                 mp 149–151° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.68(s, 3H), 3.13(s, 3H), 3.20(s, 3H), 3.69(s, 3H), 3.71(s, 3H), 5.20(s, 2H), 7.18(d, J=8.7Hz, 1H), 
               
               
                   
                 7.21(s, 1H), 7.35–7.50(m, 9H), 7.63(d, J=8.1Hz, 2H) 
               
               
                   
                 IR(KBr) 1519, 1469, 1353, 1173, 1149, 1050, 966, 873, 849, 810cm −1   
               
               
                 I-826 
                 mp 82–85° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.78(s, 3H), 1.82(s, 3H), 2.70(s, 3H), 3.20(s, 3H), 3.25(s, 3H), 3.69(s, 3H), 3.70(s, 3H), 4.65(d, J=6.9Hz, 
               
               
                   
                 2H), 5.51(t, J=6.9Hz, 1H), 7.11(d, J=8.8Hz, 1H), 7.21(s, 1H), 7.37(d, J=8.9Hz, 2H), 7.38(dd, J=8.8, 2.2Hz, 
               
               
                   
                 1H), 7.42(d, J=2.2Hz, 1H), 7.63(d, J=8.9Hz, 2H) 
               
               
                   
                 IR(KBr) 1516, 1468, 1363, 1180, 1151, 1045, 967, 846, 788cm −1   
               
               
                 I-827 
                 amorphous 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.83(s, 3H), 3.58(s, 3H), 3.70(s, 3H), 4.64(d, J=6.7Hz, 2H), 4.97(s, 1H), 5.04(s, 1H), 
               
               
                   
                 5.53(t, J=6.7Hz, 1H), 5.81(s, 1H), 6.73(s, 1H), 6.87(dd, J=8.1, 2.0Hz, 1H), 6.88(d, J=8.7Hz, 2H), 6.99(d, J=2.0Hz, 
               
               
                   
                 1H), 7.00(d, J=8.1Hz, 1H), 7.47(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3595, 3536, 1613, 1584, 1521, 1474, 1406, 1356, 1266, 1094, 1062, 1014, 973, 835cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 164 
               
               
                   
               
             
            
               
                 I-828 
                 mp 161–162° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.58(s, 3H), 3.71(s, 3H), 4.85(s, 1H), 4.93(s, 1H), 5.18(s, 2H), 5.78(s, 1H), 6.73(s, 1H), 6.87–6.92(m, 
               
               
                   
                 3H), 7.02(d, J=1.8Hz, 1H), 7.07(d, J=8.1Hz, 1H), 7.37–7.51(m, 7H) 
               
               
                   
                 IR(KBr) 3510, 3442, 3326, 1523, 1485, 1453, 1395, 1239, 1061, 1003, 972, 836, 753cm −1   
               
               
                 I-829 
                 mp 85–87° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.69(s, 3H), 1.75(s, 3H), 2.57(q, J=6.9Hz, 2H), 2.70(s, 3H), 3.20(s, 3H), 3.24(s, 3H), 3.69(s, 3H), 
               
               
                   
                 3.69(s, 3H), 4.09(t, J=6.9Hz, 2H), 5.22(t, J=6.9Hz, 1H), 7.10(d, J=8.4Hz, 1H), 7.21(s, 1H), 7.37–7.44(m, 9H), 7.63(d, 
               
               
                   
                 J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 1519, 1468, 1362, 1179, 1150, 1046, 967, 865, 847cm −1   
               
               
                 I-830 
                 mp 160–162° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.38(s, 3H), 2.68(s, 3H), 3.12(s, 3H), 3.20(s, 3H), 3.69(s, 3H), 3.70(s, 3H), 5.15(s, 2H), 7.16–7.25(m, 
               
               
                   
                 4H), 7.34–7.44(m, 6H), 7.63(d, J=8.1Hz, 2H) 
               
               
                   
                 IR(KBr) 1519, 1469, 1365, 1173, 1149, 1049, 965, 873, 849, 808cm −1   
               
               
                 I-831 
                 amorphous 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.69(s, 3H), 1.76(s, 3H), 2.55(q, J=6.9Hz, 1H), 3.58(s, 3H), 3.69(s, 3H), 4.08(t, J=6.9Hz, 2H), 
               
               
                   
                 4.98(s, 1H), 5.18(s, 1H), 5.23(t, J=6.9Hz, 1H), 5.80(s, 1H), 6.72(s, 1H), 6.86–6.89(m, 3H), 6.97–7.00(m, 3H), 7.47(d, J=8.4Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3595, 3538, 1521, 1471, 1265, 1173, 1095, 1063, 1015, 835cm −1   
               
               
                 I-832 
                 mp 200–201° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.40(s, 3H), 3.58(s, 3H), 3.70(s, 3H), 4.80(s, 1H), 4.92(s, 1H), 5.13(s, 2H), 5.77(s, 1H), 6.73(s, 1H), 
               
               
                   
                 6.88(dd, J=8.1, 2.0Hz, 1H), 6.89(d, J=8.4Hz, 2H), 7.01(d, J=1.8Hz, 1H), 7.07(d, J=8.4Hz, 1H), 7.24(d, J=7.8Hz, 
               
               
                   
                 2H), 7.35(d, J=7.8Hz, 2H), 7.48(d, J=8.4Hz, 2H), 
               
               
                   
                 IR(KBr) 3419, 1610, 1523, 1485, 1393, 1243, 1065, 1004, 972, 833, 795cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 165 
               
               
                   
               
             
            
               
                 I-833 
                 mp 141–142° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.03(s, 3H), 2.11(s, 3H), 2.54(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 5.20(s, 2H), 7.12–7.26(m, 5H), 7.38–7.50 
               
               
                   
                 (m, 8H) 
               
               
                   
                 IR(KBr) 3435, 3033, 2938, 1518, 1470, 1364, 1178, 1149, 1109, 970, 871, 839cm −1   
               
               
                 I-834 
                 mp 188–189° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.49(s, 3H), 3.72(s, 3H), 5.15(s, 2H), 5.68(brs, 1H), 5.84(brs, 1H), 6.42–6.56(m, 3H), 6.98–7.08(m, 
               
               
                   
                 3H), 7.23–7.31(m, 3H), 7.23–7.31(m, 2H), 7.38–7.45(m, 4H) 
               
               
                   
                 IR(KBr) 3420, 3328, 1627, 1584, 1523, 1489, 1460, 1412, 1316, 1288, 1249, 1172, 1128, 1115, 1068, 1000, 849, 812, 746cm −1   
               
               
                 I-835 
                 mp 180–181° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.51(s, 3H), 3.75(s, 3H), 5.17(s, 2H), 5.70(brs, 1H), 5.77(brs, 1H), 6.45(s, 1H), 6.95–7.10(m, 4H), 
               
               
                   
                 7.27–7.46(m, 8H), 7.96(brs, 1H)) 
               
               
                   
                 IR(KBr) 3422, 3358, 1706, 1602, 1489, 1454, 1410, 1289, 1253, 1203, 1180, 1125, 1101, 1071, 1015cm −1   
               
               
                 I-836 
                 mp 148–149° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.77(s, 3H), 1.80(s, 3H), 2.54(s, 6H), 3.35(s, 3H), 3.42(s, 3H), 3.48(s, 3H), 4.73(d, J=4.5Hz, 
               
               
                   
                 2H), 5.50–5.53(m, 1H), 7.30–7.54(m, 8H) 
               
               
                   
                 IR(KBr) 3495, 3293, 1754, 1712, 1516, 1359, 1359, 1243, 1175, 1147, 971, 866, 845cm −1   
               
               
                 I-837 
                 mp 136–138° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.32(s, 3H), 2.50(s, 6H), 3.31(s, 3H), 3.35(s, 3H), 3.44(s, 3H), 5.23(s, 2H), 7.21–7.47(m, 12H) 
               
               
                   
                 IR(KBr) 3495, 3292, 3028, 2934, 1754, 1710, 1516, 1357, 1176, 1147, 972, 868, 842cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 166 
               
               
                   
               
             
            
               
                 I-838 
                 mp 195–196° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.44(t, J=7.2Hz, 3H), 3.46(s, 3H), 3.69(s, 3H), 3.86(s, 6H), 4.44(q, J=7.0Hz, 2H), 5.15(s, 2H), 
               
               
                   
                 5.66(brs, 1H), 5.72(brs, 1H), 6.27(s, 1H), 7.01(s, 2H), 7.13(s, 1H), 7.38–7.46(m, 7H) 
               
               
                   
                 IR(KBr) 3485, 2937, 1713, 1580, 1464, 1455, 1407, 1324, 1243, 1123, 1102, 1069, 1014, 763cm −1   
               
               
                 I-839 
                 mp 150–151° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.76(s, 3H), 1.88(s, 3H), 1.90(s, 3H), 4.55(d, J=5.8Hz, 2H), 5.44–5.50(m, 1H), 
               
               
                   
                 6.80–6.97(m, 8H), 7.81(brs, 1H), 8.85(brs, 1H), 9.38(brs, 1H) 
               
               
                   
                 IR(KBr) 3495, 3293, 1753, 1711, 1429, 1390, 1360, 1242, 1217, 1178, 1143, 781cm −1   
               
               
                 I-840 
                 mp 149–150° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.71(s, 3H), 1.75(s, 3H), 2.00(s, 6H), 2.59(s, 3H), 4.57(d, J=6.4Hz, 2H), 5.42–5.47(m, 1H), 
               
               
                   
                 6.84–7.13(m, 8H), 9.13(brs, 1H), 9.50(brs, 1H) 
               
               
                   
                 IR(KBr) 3451, 2933, 1612, 1587, 1518, 1472, 1348, 1259, 1211, 1171, 1121, 1087, 969, 872, 835, 813cm −1   
               
               
                 I-841 
                 mp 203–204° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.87(s, 3H), 1.89(s, 3H), 2.31(s, 3H), 5.09(s, 2H), 6.80–7.00(m, 8H), 7.20(d, J=7.8Hz, 2H), 7.39 
               
               
                   
                 (d, J=7.8Hz, 2H), 7.81(brs, 1H), 8.97(brs, 1H), 9.38(brs, 1H) 
               
               
                   
                 IR(KBr) 3491, 3398, 2921, 1611, 1516, 1476, 1259, 1183, 1155, 996, 794cm −1   
               
               
                 I-842 
                 mp 128–129° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.01(s, 6H), 2.34(s, 3H), 2.63(s, 3H), 5.12(s, 2H), 6.85–7.13(m, 8H), 7.18(d, J=7.6Hz, 2H), 7.36 
               
               
                   
                 (d, J=7.6Hz, 2H), 9.15(brs, 1H), 9.55(brs, 1H) 
               
               
                   
                 IR(KBr) 3432, 3305, 1735, 1607, 1523, 1482, 1398, 1360, 1294, 1284, 1179, 1080, 816cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 167 
               
               
                   
               
             
            
               
                 I-843 
                 mp 203–204° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.66(s, 3H), 3.13(s, 3H), 3.59(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.13–7.69(m, 11H), 8.07 
               
               
                   
                 (brs, 1H) 
               
               
                   
                 IR(KBr) 3432, 3305, 1735, 1607, 1523, 1482, 1398, 1360, 1294, 1284, 1179, 1080, 816cm −1   
               
               
                 I-844 
                 mp 109–110° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.36(t, J=7.2Hz, 3H), 2.82(s, 3H), 3.24(s, 3H), 3.47(s, 3H), 3.66(s, 3H), 3.79(s, 6H), 4.38(q, J=7.0Hz, 
               
               
                   
                 2H), 5.26(s, 2H), 6.78(s, 1H), 7.32–7.52(m, 10H) 
               
               
                   
                 IR(KBr) 3432, 2940, 1716, 1579, 1465, 1407, 1366, 1322, 1240, 1179, 1123, 1078, 815, 796cm −1   
               
               
                 I-845 
                 mp 113–115° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.25(s, 3H), 2.27(s, 3H), 3.20(s, 3H), 5.20(s, 2H), 7.03–7.15(m, 5H), 7.33–7.51(m, 9H) 
               
               
                   
                 IR(CHCl 3 ) 2925, 1618, 1580, 1521, 1455, 1373, 1314, 1299, 1268, 1174, 1149, 1126, 1018, 970, 874cm −1   
               
               
                 I-846 
                 mp 155–157° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.26(s, 6H), 4.69(s, 1H), 5.19(s, 2H), 6.87–6.90(m, 2H), 7.03–7.15(m, 5H), 7.22–7.50(m, 7H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 2952, 2924, 1612, 1582, 1523, 1490, 1455, 1425, 1383, 1259, 1171, 1125, 1012, 956, 877cm −1   
               
               
                 I-847 
                 mp 81–84° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.07–1.14(m, 6H), 2.55–2.66(m, 4H), 4.73(s, 1H), 5.16(s, 2H), 5.70(s, 1H), 6.82–6.91(m, 3H), 6.92–6.99 
               
               
                   
                 (m, 2H), 7.10–7.12(d, J=4.2Hz, 2H), 7.22–7.25(m, 2H), 7.38–7.49(m, 5H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 3542, 2968, 2932, 2872, 1731, 1611, 1588, 1520, 1489, 1455, 1380, 1327, 1289, 1256, 1171, 1126, 1011, 
               
               
                   
                 903, 878, 836cm −1   
               
               
                 I-848 
                 mp 125–127° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.26(s, 3H), 2.28(s, 3H), 3.20(s, 3H), 4.63–4.65(d, J=6.9Hz, 2H), 5.56(m, 
               
               
                   
                 1H), 7.02–7.13(m, 5H), 7.31–7.43(m, 4H) 
               
               
                   
                 IR(CHCl 3 ) 2924, 1619, 1578, 1488, 1373, 1298, 1266, 1174, 1149, 1125, 970, 874cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 168 
               
               
                   
               
             
            
               
                 I-849 
                 mp 141–143° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.07–1.14(m, 6H), 2.53–2.65(m, 4H), 3.12(s, 3H), 3.20(s, 3H), 5.18(s, 2H), 7.10–7.14(m, 3H), 7.24–7.27 
               
               
                   
                 (m, 2H), 7.33–7.50(m, 9H) 
               
               
                   
                 IR(CHCl 3 ) 2969, 2934, 1614, 1517, 1487, 1371, 1331, 1289, 1263, 1173, 1149, 1111, 970, 938, 872cm −1   
               
               
                 I-850 
                 mp 90–91° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.13(s, 3H), 2.29(s, 3H), 2.35(s, 3H), 3.16(s, 3H), 5.21(s, 2H), 6.87–6.90(m, 2H), 7.09–7.49(m, 11H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 1731, 1613, 1520, 1478, 1362, 1261, 1173, 1119, 1086, 1025, 972, 953, 874cm −1   
               
               
                 I-851 
                 mp 94–96° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76–1.77(d, J=0.3Hz, 3H), 1.81–1.82(d, J=0.9Hz, 3H), 2.26(s, 3H), 2.27(s, 3H), 4.62–4.64(d, J=6.9Hz, 
               
               
                   
                 2H), 4.71(s, 1H), 5.56(m, 1H), 6.87–6.91(m, 2H), 7.00–7.13(m, 5H), 7.23–7.27(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 2923, 1675, 1613, 1579, 1523, 1490, 1386, 1297, 1171, 1124, 990, 956, 877, 836cm −1   
               
               
                 I-852 
                 mp 106–108° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.63(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 5.24(s, 2H), 6.84(s, 1H), 6.84(s, 1H), 7.12–7.20(m, 3H), 7.35–7.50 
               
               
                   
                 (m, 7H), 7.56–7.64(m, 2H) 
               
               
                   
                 IR(KBr) 2935, 1604, 1523, 1483, 1373, 1232, 1086, 1011, 945, 847, 728, 605, 523, 506cm −1   
               
               
                 I-853 
                 mp 136–138° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.67(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 4.67(d, J=6.9Hz, 2H), 5.47–5.53(m, 
               
               
                   
                 1H), 6.84(s, 1H), 7.10–7.19(m, 3H), 7.31(d, J=2.1Hz, 1H), 7.38(dd, J=2.1, 8.1Hz, 1H), 7.57–7.64(m, 2H) 
               
               
                   
                 IR(KBr) 2936, 1604, 1523, 1484, 1435, 1373, 1225, 1086, 1011, 943, 848, 783, 606, 508cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 169 
               
               
                   
               
             
            
               
                 I-854 
                 mp 128–130° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.74(s, 3H), 1.81(s, 3H), 2.62(s, 3H), 3.52(s, 3H), 3.79(s, 3H), 4.63–4.67(m, 2H), 5.45–5.53(m, 1H), 
               
               
                   
                 6.86(s, 1H), 7.01(dd, J=2.1Hz, 8.4Hz, 1H), 7.10(d, J=1.8Hz, 1H), 7.13–7.20(m, 2H), 7.29(d, J=8.4Hz, 1H), 7.59–7.64 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(KBr) 2940, 1600, 1518, 1484, 1418, 1366, 1232, 1080, 984, 893, 838, 812, 621, 524cm −1   
               
               
                 I-855 
                 mp 141–143° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 2.61(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.47–5.53(m, 
               
               
                   
                 1H), 5.70(s, 1H), 6.83(s, 1H), 6.91(dd, J=2.1, 8.1Hz, 1H), 6.96(d, J=8.1Hz, 1H), 7.02(d, J=2.1Hz, 1H), 7.10–7.19(m, 
               
               
                   
                 2H), 7.59–7.64(m, 2H) 
               
               
                   
                 IR(KBr) 3531, 2931, 1604, 1520, 1484, 1372, 1233, 1175, 1083, 1011, 814, 800, 781, 727, 526cm −1   
               
               
                 I-856 
                 mp 217–220° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.75(s, 3H), 3.51(s, 3H), 3.78(s, 3H), 5.78(s, 1H), 6.85(s, 1H), 7.03(dd, J=1.8, 8.4Hz, 1H), 7.11–7.20 
               
               
                   
                 (m, 3H), 7.32(d, J=8.4Hz, 1H), 7.58–7.63(m, 2H) 
               
               
                   
                 IR(KBr) 3434, 2941, 1611, 1487, 1423, 1363, 1209, 1076, 891, 818, 621, 573, 513cm −1   
               
               
                 I-857 
                 mp 183–185° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.92(s, 3H), 3.20(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 3.93(s, 3H), 4.31(s, 4H), 6.79–6.83(m, 2H), 6.90–6.94 
               
               
                   
                 (m, 2H), 7.16–7.41(m, 12H), 7.66–7.71(m, 2H), 
               
               
                   
                 IR(KBr) 3030, 2936, 1604, 1517, 1482, 1362, 1232, 1232, 1180, 1120, 1082, 877, 799, 701, 526cm −1   
               
               
                 I-858 
                 mp 192–194° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.57(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 3.87(s, 3H), 6.77–6.89(m, 4H), 7.34–7.40(m, 2H), 
               
               
                   
                 7.67–7.72(m, 2H) 
               
               
                   
                 IR(KBr) 3451, 3368, 2937, 1622, 1524, 1481, 1359, 1174, 1149, 1086, 962, 869, 802, 525cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 170 
               
               
                   
               
             
            
               
                 I-859 
                 mp 210–212° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.92(s, 3H), 2.23(s, 3H), 3.46(s, 3H), 3.74(s, 3H), 3.89(s, 3H), 5.24(s, 1H), 5.80(s, 1H), 5.94(s, 1H), 
               
               
                   
                 6.46(s, 1H), 6.90–6.96(m, 1H), 7.01(d, J=1.8Hz, 1H), 7.08(dd, J=1.8, 8.1Hz, 1H), 7.50–7.55(m, 2H), 7.76(s, 1H), 8.52 
               
               
                   
                 (d, J=8.1Hz, 1H), 
               
               
                   
                 IR(KBr) 3420, 2938, 1636, 1610, 1526, 1496, 1398, 1225, 1164, 1073, 1026, 831cm −1   
               
               
                 I-860 
                 mp 183–185° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.43(s, 6H), 2.45(s, 6H), 5.13(s, 2H), 6.76–6.82(m, 4H), 6.91(dd, J=2.1, 8.4Hz, 1H), 7.01(d, J=8.4Hz, 
               
               
                   
                 1H), 7.09(d, J=2.1Hz, 1H), 7.31–7.43(m, 5H), 7.48–7.53(m, 2H), 9.02(br s, 1H), 9.32(br s, 1H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1609, 1581, 1521, 1493, 1455, 1437, 1384, 1321, 1275, 1215, 1193, 1142, 1007cm −1   
               
               
                 I-861 
                 mp 172–174° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.50(s, 6H), 2.53(s, 6H), 3.11(s, 3H), 3.19(s, 3H), 5.18(s, 2H), 6.89(s, 1H), 6.93(s, 1H), 7.12(d, J=8.4Hz, 
               
               
                   
                 1H), 7.30–7.54(m, 8H), 7.66–7.71(m, 2H), 7.73(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1613, 1518, 1491, 1455, 1361, 1348, 1276, 1178, 1159, 1109, 970cm −1   
               
               
                 I-862 
                 mp 173–175° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.51(s, 6H), 2.53(s, 6H), 3.19(s, 3H), 3.22(s, 3H), 4.63(d, J=7.2Hz, 2H), 
               
               
                   
                 5.49–5.53(m, 1H), 6.89(s, 1H), 6.93(s, 1H), 7.05(d, J=9.0Hz, 1H), 7.26–7.35(m, 2H), 7.51(dd, J=1.8, 8.1Hz, 1H), 7.67–7.70 
               
               
                   
                 (m, 3H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1519, 1491, 1363, 1331, 1291, 1257, 1175, 1147, 1105, 1013, 980, 966cm −1   
               
               
                 I-863 
                 mp 150–152° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.76(s, 3H), 2.43(s, 6H), 2.45(s, 6H), 4.55(d, J=6.6Hz, 2H), 5.47–5.51(m, 1H), 
               
               
                   
                 6.78–6.83(m, 4H), 6.90–7.06(m, 3H), 7.38–7.42(m, 2H), 8.87(br s, 1H), 9.39(br s, 1H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1610, 1585, 1522, 1495, 1476, 1448, 1385, 1292, 1275, 1199, 1171, 1136, 985, 948cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 171 
               
               
                   
               
             
            
               
                 I-864 
                 mp 175–177° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.44(s, 12H), 5.13(s, 4H), 6.77(s, 2H), 6.90–7.09(m, 8H), 7.33–7.52(m, 8H), 9.01(s, 2H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1582, 1518, 1491, 1454, 1384, 1328, 1270, 1242, 1191, 1141, 1123, 1046, 1006cm −1   
               
               
                 I-865 
                 mp 175–177° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.52(s, 12H), 3.11(s, 6H), 5.17(s, 4H), 6.91(s, 2H), 7.11(d, J=8.4Hz, 2H), 7.36–7.52(m, 12H), 7.72 
               
               
                   
                 (d, J=2.1Hz, 2H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1612, 1520, 1496, 1455, 1364, 1348, 1265, 1184, 1164, 1117, 1005, 971cm −1   
               
               
                 I-866 
                 mp 180–182° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 6H), 1.81(s, 6H), 2.52(s, 12H), 3.22(s, 6H), 4.63(d, J=6.9Hz, 2H), 5.49–5.54(m, 2H), 6.90 
               
               
                   
                 (s, 2H), 7.04(d, J=8.4Hz, 2H), 7.50(dd, J=2.1, 8.4Hz, 2H), 7.04(d, J=2.1Hz, 2H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1520, 1494, 1365, 1274, 1186, 1161, 1113, 996, 973cm −1   
               
               
                 I-867 
                 mp 165–168° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.72(s, 6H), 1.76(s, 6H), 2.45(s, 12H), 4.55(d, J=6.0Hz, 4H), 5.45–5.55(m, 2H), 6.77(s, 2H), 
               
               
                   
                 6.89–6.98(m, 4H), 7.03–7.07(m, 2H), 8.86(br s, 2H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1579, 1519, 1497, 1476, 1456, 1384, 1277, 1238, 1195, 1142, 1126, 1050, 994cm −1   
               
               
                 I-868 
                 mp 76–78° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.47(s, 3H), 3.75(s, 3H), 3.94(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 5.69(s, 1H), 5.92(s, 1H), 6.46(s, 1H), 
               
               
                   
                 6.93–7.15(m, 5H), 7.22(d, J=1.5Hz, 1H), 7.34–7.49(m, 5H) 
               
               
                   
                 IR(CHCl 3 ) 3528, 1586, 1520, 1489, 1461, 1399, 1287, 1260, 1110, 1070, 1010, 907, 819cm −1   
               
               
                 I-869 
                 mp 140–142° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.65(s, 3H), 3.13(s, 3H), 3.25(s, 3H), 3.57(s, 3H), 3.78(s, 3H), 3.94(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 
               
               
                   
                 7.13–7.19(m, 2H), 7.30–7.50(m, 9H) 
               
               
                   
                 IR(CHCl 3 ) 1598, 1516, 1480, 1367, 1266, 1176, 1115, 1081, 1012, 969, 918, 867, 808cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 172 
               
               
                   
               
             
            
               
                 I-870 
                 mp 189–190° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(d, J=0.9Hz, 3H), 1.81(s, 3H), 2.69(s, 3H), 3.24(s, 3H), 3.25(s, 3H), 3.58(s, 3H), 3.78(s, 3H), 
               
               
                   
                 3.94(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.49(m, 1H), 6.85(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.17(d.d, J=2.1, 8.4Hz, 1H), 
               
               
                   
                 7.30–7.42(m, 4H) 
               
               
                   
                 IR(CHCl 3 ) 2932, 1599, 1516, 1480, 1367, 1329, 1266, 1177, 1115, 1082, 1032, 1013, 970, 907, 868, 807cm −1   
               
               
                 I-871 
                 mp 187–190° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.38(s, 3H), 2.64(s, 3H), 3.13(s, 3H), 3.25(s, 3H), 3.58(s, 3H), 3.78(s, 3H), 3.94(s, 3H), 5.14(s, 2H), 
               
               
                   
                 6.84(s, 1H), 7.13–7.24(m, 4H), 7.30–7.42(m, 6H) 
               
               
                   
                 IR(CHCl 3 ) 2966, 1598, 1517, 1480, 1462, 1368, 1329, 1267, 1177, 1116, 1082, 1032, 970, 907, 867, 808cm −1   
               
               
                 I-872 
                 mp 192–194° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.15(t, J=6.9Hz, 3H), 1.76(s, 3H), 1.82(s, 3H), 2.59(s, 3H), 3.69(q, J=6.9Hz, 2H), 3.77(s, 3H), 
               
               
                   
                 4.61(d, J=6.9Hz, 2H), 4.99(s, 1H), 5.50(m, 1H), 5.70(s, 1H), 6.84(s, 1H), 6.88–6.97(m, 3H), 7.02(d, J=1.8Hz, 1H), 
               
               
                   
                 7.52–7.58(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3536, 2934, 1609, 1520, 1482, 1410, 1365, 1279, 1243, 1172, 1128, 1080, 1029, 972, 952, 872, 833, 812cm −1   
               
               
                 I-873 
                   1 H NMR(CDCl 3 ) δ 3.46(s, 3H), 3.70(s, 2H), 3.74(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.67(s, 1H), 5.90(s, 1H), 6.47(s, 1H), 
               
               
                   
                 6.96(d.d, J=8.4 &amp; 1.8Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.33–7.44(m, 7H), 7.61(.d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 3536, 3389, 1732, 1587, 1519, 1487, 1438, 1393, 1249, 1217, 1166, 1110, 1069, 1001cm −1   
               
               
                 I-874 
                   1 H NMR(CDCl 3 ) δ 3.46(s, 3H), 3.74(s, 5H), 5.15(s, 2H), 5.68(s, 1H), 5.91(s, 1H), 6.47(s, 1H), 6.96(d.d, J=8.4 &amp; 1.8Hz, 
               
               
                   
                 1H), 7.03(.d, J=8.4Hz, 1H), 7.09(.d, J=8.4Hz, 1H), 7.32–7.49(m, 7H), 7.62(d, J=8.1Hz, 2H) 
               
               
                   
                 IR(KBr) 3381, 1715, 1698, 1608, 1581, 1523, 1485, 1455, 1396, 1294, 1235, 1112 1072, 1017cm −1   
               
               
                 I-875 
                   1 H NMR(CDCl 3 ) δ 2.69(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.70(s, 2H), 3.74(s, 3H), 3.77(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 
               
               
                   
                 7.15(d, J=8.7Hz, 1H), 7.30–7.40(m, 9H), 7.59(.d, J=8.1Hz, 2H) 
               
               
                   
                 IR(KBr) 1734, 1721, 1606, 1481, 1398, 1361, 1244, 1175, 1120, 1078, 1010cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 173 
               
               
                   
               
             
            
               
                 I-876 
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.23(s, 3H), 3.54(s, 3H), 3.70(s, 2H), 3.74(s, 3H), 3.77(s, 3H), 
               
               
                   
                 4.64(d, J=6.9Hz, 2H), 5.46–5.55(m, 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.35(d.d, J=8.4 &amp; 2.1Hz, 1H), 7.37 
               
               
                   
                 (d, J=8.1Hz, 2H), 7.39(d, J=2.1Hz, 1H), 7.59(d, J=8.1Hz, 2H) 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 
               
               
                   
                 IR(KBr) 3447, 1735, 1608, 1522, 1482, 1365, 1177, 1117, 1078, 1013cm −1   
               
               
                 I-877 
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.74(s, 5H), 3H), 4.62(d, J=6.9Hz, 2H), 5.46–5.58(m, 1H), 
               
               
                   
                 5.69(s, 1H), 5.89(s, 1H), 6.47(s, 1H), 6.96(s, 2H), 7.06(s, 1H), 7.38(d, J=8.4Hz, 2H), 7.62(d, J=8.4Hz, 2H) 
               
               
                 I-878 
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.70(s, 2H), 3.74(s, 6H), 4.62(d, J=6.9Hz, 2H), 5.46 –5.58(m, 
               
               
                   
                 1H), 5.68(s, 1H), 5.88(s, 1H), 6.47(s, 1H), 6.96(s, 2H), 7.06(s, 1H), 7.37(d, J=8.4Hz, 2H), 7.61(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 3527, 3386, 1734, 1609, 1586, 1520, 1487, 1439, 1396, 1219, 1167, 1111, 1068, 1010cm −1   
               
               
                 I-879 
                 mp 136–139° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.7(br s, 1H), 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.23(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 4.64(d, J=6.7Hz, 
               
               
                   
                 2H), 4.78(s, 2H), 5.49(t, J=6.8Hz, 1H), 6.87(s, 1H), 7.09(d, J=8.6Hz, 1H), 7.35(dd, J=8.6, 2.1Hz, 1H), 7.40(d, 
               
               
                   
                 J=2.1Hz, 1H), 7.47(d, J=8.1Hz, 2H), 7.64(d, J=8.1Hz, 2H) 
               
               
                   
                 IR(KBr) 3553, 3434, 1481, 1389, 1363, 1235, 1175, 1084, 1011, 972, 806cm −1   
               
               
                 I-880 
                 mp 180–181° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.70(br s, 1H), 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 2H), 4.77(s, 
               
               
                   
                 2H), 5.53(t, J=6.9Hz, 1H), 5.69(s, 1H), 5.89(s, 1H), 6.47(s, 1H), 6.94–6.96(m, 2H), 7.05–7.07(m, 1H), 7.46(d, J=8.1Hz, 
               
               
                   
                 2H), 7.65(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 3509, 3367, 1522, 1487, 1461, 1396, 1289, 1249, 1213, 1116, 1071, 1009, 992, 942, 797, 782cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 174 
               
               
                   
               
             
            
               
                 I-881 
                 mp 122–123° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.34(t, J=6.5Hz, 1H), 3.22(s, 3H), 3.45(s, 3H), 3.73(s, 3H), 4.5(m, 2H), 
               
               
                   
                 4.64(d, J=6.6Hz, 2H), 5.56(t, J=6.6Hz, 1H), 6.84(s, 1H), 6.99–7.10(m, 3H), 7.39(d, J=8.7Hz, 2H), 7.71(d, J=8.7Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3579, 1518, 1471, 1360, 1261, 1230, 1148, 1019, 966, 881, 843cm −1   
               
               
                 I-882 
                 mp 156–158° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.49(t, J=6.6Hz, 1H), 3.44(s, 3H), 3.72(s, 3H), 4.49(br s, 2H), 4.63(d, J=6.7Hz, 
               
               
                   
                 2H), 5.04(s, 1H), 5.55(t, J=6.7Hz, 1H), 6.85(s, 1H), 6.92(d, J=8.9Hz, 2H), 6.98–7.10(m, 3H), 7.53(d, J=8.9Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3433, 3234, 1609, 1520, 1472, 1266, 1227, 994, 836cm −1   
               
               
                 I-883 
                 mp 168–170° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.50(t, J=6.5Hz, 1H), 3.44(s, 3H), 3.73(s, 3H), 4.49(br s, 2H), 4.78(d, J=6.1Hz, 2H), 5.06(s, 1H), 
               
               
                   
                 6.24(t, J=6.1Hz, 1H), 6.85(s, 1H), 6.93(d, J=8.6Hz, 2H), 6.97–7.13(m, 3H), 7.53(d, J=8.6Hz, 2H) 
               
               
                   
                 IR(KBr) 3544, 3412, 3267, 1613, 1521, 1475, 1263, 1229, 1011, 884, 816cm −1   
               
               
                 I-884 
                 mp 153–154° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.49(s, 3H), 3.77(s, 3H), 5.17(s, 2H), 5.76(brs, 2H), 6.45(s, 1H), 6.91–7.07(m, 3H), 7.26–7.45(m, 5H), 
               
               
                   
                 7.93(d, J=8.2Hz, 2H), 8.00(brs, 1H), 8.27(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 3448, 2962, 2938, 1738, 1627, 1604, 1589, 1519, 1486, 1319, 1250, 1153, 1115, 1071, 1011cm −1   
               
               
                 I-885 
                 mp 81–82° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.51(s, 3H), 1.54(s, 3H), 1.74(s, 3H), 1.77(s, 3H), 2.70(s, 3H), 3.24(s, 3H), 3.60(s, 3H), 3.78(s, 3H), 
               
               
                   
                 4.38(d, J=7.5Hz, 2H), 4.65(d, J=6.6Hz, 2H), 6.86(s, 1H), 7.06–7.11(m, 3H), 7.35–7.41(m, 2H), 7.52–7.57(m, 1H) 
               
               
                   
                 IR(KBr) 3433, 2938, 1699, 1618, 1521, 1481, 1367, 1209, 1178, 1115, 1081, 972, 950, 813, 793cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 175 
               
               
                   
               
             
            
               
                 I-886 
                 mp 208–209° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.23(s, 3H), 3.60(s, 3H), 3.76(s, 3H), 4.64(d, J=7.2Hz, 2H), 
               
               
                   
                 5.49(t, J=8.7Hz, 1H), 6.85(s, 1H), 7.09(d, J=8.7Hz, 1H), 7.26–7.40(m, 3H), 7.52–7.58(m, 1H), 7.69–7.73(m, 1H), 8.02 
               
               
                   
                 (brs, 1H) 
               
               
                   
                 IR(KBr) 3357, 2939, 1736, 1606, 1523, 1483, 1398, 1370, 1294, 1243, 1179, 1111, 1079, 965, 827, 814, 795cm −1   
               
               
                 I-887 
                 mp 89–90° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.34(s, 3H), 2.38(s, 3H), 2.64(s, 3H), 3.12(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.92(s, 2H), 5.14(s, 2H), 
               
               
                   
                 6.83(s, 1H), 6.89(d, J=8.7Hz, 2H), 7.11–7.46(m, 12H) 
               
               
                   
                 IR(KBr) 3434, 2939, 1699, 1617, 1520, 1481, 1367, 1211, 1178, 1114, 1081, 952, 813, 794cm −1   
               
               
                 I-888 
                 mp 181–182° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.38(s, 3H), 2.66(s, 3H), 3.12(s, 3H), 3.59(s, 3H), 3.76(s, 3H), 5.14(s, 2H), 6.85(s, 1H), 7.14–7.41(m, 
               
               
                   
                 8H), 7.52–7.58(m, 1H), 7.69–7.73(m, 1H), 8.02(brs, 1H) 
               
               
                   
                 IR(KBr) 3348, 3030, 2940, 1733, 1607, 1523, 1482, 1397, 1366, 1281, 1242, 1212, 1179, 1128, 1112, 1080, 971, 944, 815, 
               
               
                   
                 799cm −1   
               
               
                 I-889 
                 mp 155–157° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.46(t, J=7.0Hz, 3H), 1.76(s, 3H), 1.82(s, 3H), 2.73(s, 3H), 3.23(s, 3H), 3.56(s, 3H), 3.74(s, 3H), 
               
               
                   
                 4.46(q, J=7.4Hz, 2H), 4.65(d, J=7.2Hz, 2H), 5.48–5.54(m, 1H), 6.69(s, 1H), 7.09(d, J=8.4Hz, 2H), 7.28–7.47(m, 4H) 
               
               
                   
                 IR(KBr) 3434, 2938, 1716, 1579, 1477, 1464, 1409, 1366, 1241, 1178, 1124, 1078, 955, 815, 796cm −1   
               
               
                 I-890 
                 mp 82–83° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.67(s, 3H), 3.13(s, 3H), 3.58(s, 3H), 3.80(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 7.13–7.49(m, 8H), 7.89–7.96 
               
               
                   
                 (m, 2H), 8.27(brs, 1H), 8.27–8.31(m, 1H) 
               
               
                   
                 IR(KBr) 3447, 3033, 2940, 1743, 1521, 1482, 1367, 1312, 1272, 1249, 1178, 1119, 1080, 957, 817, 799cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 176 
               
               
                   
               
             
            
               
                 I-891 
                 mp 86–87° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.68(s, 3H), 3.10(s, 3H), 3.15(s, 3H), 3.62(s, 3H), 3.81(s, 3H), 5.22(s, 2H), 6.85(s, 1H), 7.16–7.50(m, 
               
               
                   
                 9H), 7.88–7.91(m, 2H) 
               
               
                   
                 IR(KBr) 3413, 2938, 1519, 1483, 1366, 1313, 1162, 1119, 1090, 1079, 957, 812cm −1   
               
               
                 I-892 
                 mp 97–98° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.53(s, 3H), 1.55(s, 3H), 1.76(s, 3H), 1.78(s, 3H), 3.63(s, 3H), 3.75(s, 3H), 4.26(d, J=7.4Hz, 2H), 
               
               
                   
                 4.62(d, J=6.8Hz, 2H), 5.65(brs, 1H), 5.72(brs, 1H), 6.84(s, 1H), 7.04–7.13(m, 3H), 7.35–7.43(m, 2H), 7.51–7.58(m, 1H) 
               
               
                   
                 IR(KBr) 3453, 3379, 2973, 2931, 1719, 1629, 1529, 1490, 1406, 1313, 1288, 1247, 1193, 1101, 1072, 1015, 993, 816, 786cm −1   
               
               
                 I-893 
                 mp 89–90° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.75(s, 3H), 1.78(s, 3H), 3.31(s, 3H), 3.62(s, 3H), 4.56(d, J=6.9Hz, 2H), 5.52(t, J=6.0Hz, 1H), 
               
               
                   
                 6.33(s, 1H), 6.34–6.47(m, 2H), 6.74(brs, 2H), 6.74–6.75(m, 1H), 6.87–6.91(m, 1H), 7.11–7.12(m, 1H), 7.32–7.34(m, 1H), 
               
               
                   
                 8.52(brs, 1H), 8.75(brs, 1H) 
               
               
                   
                 IR(KBr) 3424, 2933, 2614, 1719, 1625, 1585, 1523, 1488, 1408, 1287, 1247, 1125, 1070, 819, 788cm −1   
               
               
                 I-894 
                 mp 167–168° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.31(s, 3H), 2.38(s, 3H), 3.52(s, 3H), 3.76(s, 3H), 4.91(s, 2H), 5.13(s, 2H), 5.65(brs, 1H), 5.77(brs, 
               
               
                   
                 1H), 6.85(s, 1H), 6.84–6.93(m, 2H), 7.10–7.44(m, 12H) 
               
               
                   
                 IR(KBr) 3425, 2933, 2614, 1719, 1625, 1585, 1522, 1488, 1408, 1287, 1247, 1125cm −1   
               
               
                 I-895 
                 mp 93–94° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.11(s, 3H), 3.34(s, 3H), 3.62(s, 3H), 5.10(s, 2H), 6.32(s, 2H), 6.41–6.49(m, 2H), 6.65(d, J=9.3Hz, 
               
               
                   
                 1H), 6.78(s, 1H), 6.95(d, J=8.7Hz, 1H), 7.09–7.14(m, 1H), 7.22(d, J=8.4Hz, 2H), 7.41(d, J=8.1Hz, 2H), 8.49(brs, 
               
               
                   
                 1H), 8.87(brs, 1H) 
               
               
                   
                 IR(KBr) 3424, 2932, 1717, 1626, 1585, 1523, 1488, 1409, 1248, 1125, 1106, 1070, 811, 793cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 177 
               
               
                   
               
             
            
               
                 I-896 
                 mp 149–150° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.77(s, 3H), 3.32(s, 3H), 3.55(s, 3H), 3.76(s, 6H), 4.55(d, J=6.3Hz, 2H), 5.50(t, J=6.6Hz, 
               
               
                   
                 1H), 6.15(s, 1H), 6.68(d, J=2.1Hz, 1H), 6.91(d, J=8.7Hz, 1H), 7.30(s, 2H), 8.41(brs, 1H), 8.74(brs, 1H) 
               
               
                   
                 IR(KBr) 3423, 2936, 1694, 1578, 1459, 1410, 1319, 1229, 1126, 1067cm −1   
               
               
                 I-897 
                 mp 107–108° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.70(s, 3H), 3.12(s, 3H), 3.55(s, 3H), 3.72(s, 3H), 3.78(s, 6H), 5.18(s, 2H), 6.65(s, 1H), 6.70(d, J=4.2Hz, 
               
               
                   
                 1H), 7.14(d, J=8.4Hz, 1H), 7.26–7.48(m, 9H) 
               
               
                   
                 IR(KBr) 3434, 2941, 1517, 1488, 1366, 1353, 1261, 1177, 1102, 1074, 844, 818, 796cm −1   
               
               
                 I-898 
                 powder 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.63(s, 3H), 1.70(s, 3H), 3.48(s, 3H), 3.73–3.76(m, 7H), 3.87(s, 3H), 4.98(s, 1H), 5.24–5.32(m, 2H), 
               
               
                   
                 5.90(s, 1H), 6.47(s, 1H), 6.89–7.02(m, 5H), 7.51–7.57(m, 2H) 
               
               
                   
                 IR(KBr) 3447, 2930, 1612, 1523, 1488, 1455, 1398, 1230, 1120, 1080, 1037, 818, 592cm −1   
               
               
                 I-899 
                 mp 171–173° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.73(s, 3H), 1.76(s, 3H), 3.48(s, 3H), 3.73–3.76(m, 5H), 4.23(s, 1H), 4.92(s, 1H), 5.37–5.43(m, 1H), 
               
               
                   
                 5.84(s, 1H), 6.46(s, 1H), 6.70(d, J=8.1Hz, 1H), 6.86–7.01(m, 5H), 7.51–7.56(m, 2H) 
               
               
                   
                 IR(KBr) 3392, 2934, 1612, 1526, 1489, 1398, 1222, 1116, 1075, 829, 590cm −1   
               
               
                 I-900 
                 mp 78–79° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.14(s, 3H), 2.29(s, 3H), 2.36(s, 3H), 3.16(s, 3H), 3.20(s, 3H), 5.22(s, 2H), 7.10(s, 1H), 7.16(d, J=8.7Hz, 
               
               
                   
                 1H), 7.22–7.49(m, 11H) 
               
               
                   
                 IR(CHCl 3 ) 2939, 1612, 1516, 1476, 1415, 1370, 1291, 1269, 1174, 1150, 1119, 1087, 1018, 971, 954, 873cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 178 
               
               
                   
               
             
            
               
                 I-901 
                 mp 114–116° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.08–1.14(m, 6H), 1.77(s, 3H), 1.81–1.82(d, J=0.6Hz, 3H), 2.53–2.65(m, 4H), 3.21(s, 3H), 3.23(s, 
               
               
                   
                 3H), 4.62–4.65(d, J=6.6Hz, 2H), 5.52(m, 1H), 7.04–7.13(m, 2H), 7.23–7.26(m, 2H), 7.32–7.42(m, 5H) 
               
               
                   
                 IR(CHCl 3 ) 2970, 2934, 2874, 1674, 1614, 1572, 1517, 1487, 1415, 1370, 1331, 1288, 1262, 1172, 1149, 1109, 971, 937, 872, 
               
               
                   
                 849cm −1   
               
               
                 I-902 
                 mp 97–99° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.07–1.14(m, 6H), 1.77(s, 3H), 1.83(s, 3H), 2.55–2.66(m, 4H), 4.61–4.64(d, J=6.6Hz, 2H), 5.06(s, 
               
               
                   
                 1H), 5.54(m, 1H), 5.77(s, 1H), 7.24–7.64(m, 4H), 6.97(d, J=2.1Hz, 1H), 7.10–7.12(d, J=5.7Hz, 2H), 7.23–7.26(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 3537, 2969, 2933, 27873, 1675, 1612, 1586, 1520, 1489, 1385, 1327, 1290, 1257, 1171, 1125, 996, 903, 877, 
               
               
                   
                 836cm −1   
               
               
                 I-903 
                 mp 69–71° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.78(s, 3H), 1.82(s, 3H), 2.15(s, 3H), 2.30(s, 3H), 2.43(s, 3H), 2.43(s, 3H), 3.21(s, 3H), 3.27(s, 3H), 
               
               
                   
                 4.64–4.67(d, J=6.9Hz, 2H), 5.50(s, 2H), 7.10–7.13(d, J=9.9Hz, 2H), 7.23–7.29(m, 2H), 7.34–7.42(m, 5H) 
               
               
                   
                 IR(CHCl 3 ) 2939, 1612, 1516, 1476, 1415, 1370, 1331, 1290, 1268, 1174, 1150, 1119, 1086, 971, 954, 873cm −1   
               
               
                 I-904 
                 mp 125–127° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.27(s, 6H), 3.91(s, 3H), 4.88(br, 1H), 5.20(s, 2H), 6.83–6.96(m, 5H), 7.12–7.13(d, J=4.5Hz, 2H), 
               
               
                   
                 7.22–7.50(m, 7H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 2957, 2936, 1611, 1586, 1522, 1490, 1464, 1454, 1326, 1257, 1172, 1138, 1033, 835cm −1   
               
               
                 I-905 
                 mp 145–146° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.26(s, 3H), 2.28(s, 3H), 3.20(s, 3H), 3.91(s, 3H), 5.21(s, 2H), 6.83(dd, J=8.1, 2.1Hz, 1H), 6.91–6.96 
               
               
                   
                 (m, 2H), 7.11(s, 1H), 7.15(s, 1H), 7.32–7.50(m, 9H) 
               
               
                   
                 IR(CHCl 3 ) 2938, 1604, 1584, 1519, 1488, 1464, 1454, 1373, 1330, 1260, 1175, 1149, 1033, 1018, 970, 873, 847cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 179 
               
               
                   
               
             
            
               
                 I-906 
                 mp 132–134° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.27(s, 3H), 2.87,(s, 3H), 3.91(s, 3H), 5.16(s, 2H), 5.21(s, 2H), 5.70(s, 1H), 6.82–6.86(m, 2H), 6.92–7.00 
               
               
                   
                 (m, 4H), 7.13(s, 2H), 7.32–7.50(m, 10H) 
               
               
                   
                 IR(CHCl 3 ) 3542, 2936, 2871, 1585, 1519, 1491, 1454, 1382, 1322, 1273, 1175, 1137, 1014, 897, 877, 857cm −1   
               
               
                 I-907 
                 mp 181–182° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.13(s, 3H), 2.30(s, 3H), 2.35(s, 3H), 4.61–4.64(d, J=6.9Hz, 2H), 5.37(s, 
               
               
                   
                 1H), 5.51(m, 1H), 5.78(s, 1H), 6.81(dd, J=8.1, 2.1Hz, 1H), 6.86–6.97(m, 3H), 7.08(s, 1H), 7.19–7.22(m, 2H), 7.26(s, 1H) 
               
               
                   
                 IR(CHCl 3 ) 3595, 3536, 2936, 1613, 1587, 1519, 1479, 1453, 1359, 1330, 1279, 1246, 1173, 1127, 1085, 1024, 974, 950, 881, 
               
               
                   
                 867cm −1   
               
               
                 I-908 
                 mp 167–168° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77–1.78(d, J=0.9Hz, 3H), 1.84(s, 3H), 2.08(s, 3H), 2.15(s, 3H), 4.63–4.65(d, J=6.9Hz, 2H), 4.82 
               
               
                   
                 (s, 1H), 5.05(s, 1H), 5.55(m, 1H), 5.80(m, 1H), 6.74(s, 1H), 6.78(dd, J=8.4, 2.1Hz, 1H), 6.87–6.95(m, 3H), 7.00(d, J=8.4Hz, 
               
               
                   
                 1H), 7.23–7.26(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3594, 3534, 2923, 2869, 1675, 1613, 1584, 1520, 1488, 1455, 1399, 1289, 1247, 1166, 1127, 1091, 994, 948, 835cm −1   
               
               
                 I-909 
                 mp 170–172° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.76(s, 3H), 3.31(s, 3H), 3.63(s, 3H), 4.54(d, J=6.5Hz, 2H), 5.17(s, 2H), 5.49(t, J=6.5Hz, 
               
               
                   
                 1H), 6.36(s, 1H), 6.63(d, J=8.4Hz, 2H), 6.63(dd, J=8.4, 2.1Hz, 1H), 6.72(d, J=2.1Hz, 1H), 6.88(d, J=8.4Hz, 
               
               
                   
                 1H), 7.31(d, J=8.4Hz, 2H), 8.40(s, 1H), 8.70(s, 1H) 
               
               
                   
                 IR(KBr) 3416, 3329, 1614, 1523, 1489, 1408, 1242, 1219, 1115, 1070, 997, 817, 787cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 180 
               
               
                   
               
             
            
               
                 I-910 
                 mp 207–209° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.54(s, 9H), 2.69(s, 3H), 3.12(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 5.18(s, 2H), 6.56(s, 1H), 6.85(s, 1H), 
               
               
                   
                 7.14(d, J=8.7Hz, 1H), 7.32–7.48(m, 9H), 7.57(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3373, 1734, 1525, 1369, 1227, 1177, 1158, 1080, 816, 793cm −1   
               
               
                 I-911 
                 mp 214–216° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.84(s, 3H), 3.33(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 5.26(s, 2H), 5.30(s, 2H), 6.66(d, J=8.7Hz, 
               
               
                   
                 2H), 6.93(s, 1H), 7.24–7.45(m, 8H), 7.52(m, 2H) 
               
               
                   
                 IR(KBr) 3468, 3386, 1604, 1523, 1482, 1392, 1361, 1175, 1085, 815cm −1   
               
               
                 I-912 
                 mp 215–218° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.67(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.15(d, J=8.4Hz, 1H), 
               
               
                   
                 7.32–7.48(m, 7H), 7.69(s, 4H), 8.02(br s, 1H) 
               
               
                   
                 IR(KBr) 3307, 1733, 1482, 1393, 1361, 1284, 1177, 1084, 1012, 967, 945, 816cm −1   
               
               
                 I-913 
                 mp 203–205° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.24(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 4.64(d, J=6.8Hz, 2H), 
               
               
                   
                 5.50(t, J=6.8Hz, 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.35(dd, J=8.4, 2.0Hz, 1H), 7.39(d, J=2.0Hz, 1H), 7.69(s, 
               
               
                   
                 4H), 8.01(br s, 1H) 
               
               
                   
                 IR(KBr) 3311, 1735, 1482, 1393, 1362, 1177, 1083, 976, 945, 818cm −1   
               
               
                 I-914 
                 mp 105–107° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(s, 3H), 2.27(s, 3H), 2.29(s, 3H), 3.20(s, 3H), 3.89(s, 3H), 4.63–4.65(d, J=6.6Hz, 
               
               
                   
                 2H), 5.57(m, 1H), 6.87–6.96(m, 3H), 7.12(s, 1H), 7.17(s, 1H), 7.33–7.43(m, 4H) 
               
               
                   
                 IR(CHCl 3 ) 2937, 2866, 1604, 1583, 1519, 1488, 1464, 1373, 1331, 1259, 1175, 1149, 1035, 970, 873cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 181 
               
               
                   
               
             
            
               
                 I-915 
                 mp 164–165° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75–1.76(d, J=0.6Hz, 3H), 1.79–1.80(d, J=0.9Hz, 3H), 2.27(s, 3H), 2.28(s, 3H), 3.89(s, 3H), 
               
               
                   
                 4.62–4.65(d, J=6.6Hz, 2H), 4.78(br, 1H), 5.57(m, 1H), 6.86–6.96(m, 4H), 7.12(s, 1H), 7.15(s, 1H), 7.22–7.27(m, 3H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 2936, 2865, 1676, 1611, 1584, 1522, 1490, 1464, 1385, 1327, 1257, 1172, 1138, 1100, 1035, 996, 952, 896., 
               
               
                   
                 835cm −1   
               
               
                 I-916 
                 mp 172–173° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.72(s, 3H), 1.77(s, 6H), 1.81(s, 3H), 2.70(s, 3H), 3.11(s, 3H), 3.24(s, 3H), 3.57(s, 3H), 3.80(s, 3H), 
               
               
                   
                 4.06–4.27(m, 2H), 4.64(d, J=7.2Hz, 2H), 5.37–5.50(m, 2H), 6.85(s, 1H), 7.10(d, J=8.6Hz, 1H), 7.32–7.39(m, 2H), 7.52 
               
               
                   
                 (d, J=8.4Hz, 1H), 7.84(d, J=9.6Hz, 1H), 7.94(s, 1H) 
               
               
                   
                 IR(KBr) 3434, 1519, 1482, 1366, 1346, 1308, 1178, 1157, 1120, 1090, 1078, 957, 805cm −1   
               
               
                 I-917 
                 mp 78–80° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.47(s, 3H), 3.69(s, 6H), 3.80(s, 6H), 5.14(s, 2H), 5.66(brs, 1H), 5.76(brs, 1H), 6.30(s, 1H), 6.69(d, 
               
               
                   
                 J=8.2Hz, 2H), 7.02(s, 2H), 7.14(s, 1H), 7.34–7.46(m, 6H) 
               
               
                   
                 IR(KBr) 3443, 2935, 1614, 1587, 1517, 1470, 1250, 1110, 744cm −1   
               
               
                 I-918 
                 mp 83–84° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 3.34(s, 3H), 3.72(s, 3H), 5.13(s, 2H), 5.72(brs, 2H), 6.41(s, 1H), 6.62–6.93(m, 4H), 7.32–7.61(m, 
               
               
                   
                 7H), 8.54(brs, 1H), 8.88(brs, 1H) 
               
               
                   
                 IR(KBr) 3398, 2936, 1731, 1633, 1586, 1521, 1489, 1455, 1432, 1402, 1291, 1216, 1112, 1071cm −1   
               
               
                 I-919 
                 mp 74–75° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.02(s, 6H), 3.11(s, 3H), 3.21(s, 3H), 5.02(brs, 1H), 5.18(s, 2H), 6.96(s, 1H), 7.04–7.18(m, 3H), 
               
               
                   
                 7.37–7.59(m, 9H) 
               
               
                   
                 IR(KBr) 3503, 3032, 2937, 1513, 1474, 1365, 1289, 1197, 1175, 1149, 1114, 970, 867, 811cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 182 
               
               
                   
               
             
            
               
                 I-920 
                 mp 78–79° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.73(s, 3H), 1.78(s, 6H), 1.83(s, 3H), 3.11(s, 3H), 3.48(s, 3H), 3.77(s, 3H), 4.07–4.29(m, 2H), 4.64(d, 
               
               
                   
                 J=6.8Hz, 2H), 5.41–5.55(m, 2H), 5.73(s, 1H), 5.82(s, 1H), 6.47(s, 1H), 6.94–7.05(m, 3H), 7.53(d, J=8.0Hz, 1H), 7.86(d, 
               
               
                   
                 J=8.6Hz, 1H), 8.00(s, 1H)IR(KBr) 3449, 2971, 2935, 1519, 1489, 1424, 1338, 1310, 1226, 1152, 1117, 1070, 1059, 773cm −1   
               
               
                 I-921 
                 mp 176–177° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.10(s, 3H), 2.18(s, 3H), 2.47(s, 3H), 3.12(s, 3H), 3.23(s, 3H), 5.20(s, 2H), 7.09–7.21(m, 3H), 7.39–7.51 
               
               
                   
                 (m, 8H), 7.60(d, J=8.4Hz, 2H). 
               
               
                   
                 IR(KBr) 3433, 3033, 2937, 1516, 1470, 1360, 1291, 1267, 1176, 1150, 1119, 976, 857cm −1   
               
               
                 I-922 
                 mp 170–172° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 3.36(s, 3H), 3.66(s, 3H), 4.22(br d, J=2.5Hz, 2H), 4.50(t, J=4.5Hz, 1H), 4.57(d, J=5.7Hz, 
               
               
                   
                 2H), 4.60(d, J=5.7Hz, 2H), 4.97(t, J=5.7Hz, 2H), 5.17(s, 2H), 5.23(t, J=5.7Hz, 1H), 6.93(s, 1H), 7.04(d, J=8.4Hz, 
               
               
                   
                 1H), 7.14(dd, J=8.4, 2.3Hz, 1H), 7.28–7.37(m, 2H), 7.40–7.45(m, 4H), 7.49–7.53(m, 2H), 7.61(d, J=8.1Hz, 2H) 
               
               
                   
                 IR(KBr) 3322, 1462, 1385, 1228, 1037, 1006, 750, 700cm −1   
               
               
                 I-923 
                 mp 130–132° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.55(s, 9H), 1.62(s, 3H), 2.30(s, 12H), 3.00(s, 6H), 6.73(br s, 1H), 6.78–6.82(m, 2H), 7.07–7.14(m, 
               
               
                   
                 4H), 7.24–7.27(m, 2H), 8.07–8.13(m, 2H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1732, 1624, 1610, 1583, 1530, 1493, 1366, 1347, 1320, 1236, 1154cm −1   
               
               
                 I-924 
                 mp 104–106° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.27(s, 3H), 2.30(s, 3H), 3.00(s, 6H), 3.74(br s, 2H), 6.77–6.85(m, 3H), 6.96(dd, J=1.8, 8.1Hz, 1H), 
               
               
                   
                 7.03(dd, J=2.1, 12.0Hz, 1H), 7.09(s, 1H), 7.13(s, 1H), 7.24–7.29(m, 2H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1631, 1608, 1580, 1530, 1487, 1436, 1363, 1233, 1195cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 183 
               
               
                   
               
             
            
               
                 I-925 
                 mp 100–102° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(d, J=0.6Hz, 3H), 1.78(d, J=0.6Hz, 3H), 2.29(s, 3H), 2.30(s, 3H), 3.00(s, 6H), 3.77(d, J=6.6Hz, 
               
               
                   
                 2H), 3.87(br s, 2H), 5.37–5.40(m, 1H), 6.71–6.83(m, 3H), 7.00–7.03(m, 2H), 7.11(s, 1H), 7.13(s, 1H), 7.25–7.29(m, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1623, 1610, 1529, 1490, 1441, 1348, 1328, 1253, 1229, 1120, 1065cm −1   
               
               
                 I-926 
                 mp 178–180° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.27(s, 3H), 2.32(s, 3H), 3.01(s, 6H), 6.78–6.83(m, 2H), 7.10(s, 1H), 7.16(s, 1H), 7.18–7.28(m, 4H), 
               
               
                   
                 8.12(br s, 1H), 8.27–8.33(m, 1H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1709, 1613, 1532, 1490, 1356, 1283, 1229, 1188, 1167cm −1   
               
               
                 I-927 
                 mp 154–156° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.94(d, J=1.2Hz, 3H), 2.26(d, J=1.2Hz, 3H), 2.27(s, 3H), 2.31(s, 3H), 3.00(s, 6H), 5.79–5.80(m, 
               
               
                   
                 1H), 6.78–6.82(m, 3H), 7.09–7.16(m, 4H), 7.16–7.24(m, 2H), 8.38–8.44(m, 1H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1681, 1665, 1643, 1610, 1528, 1506, 1487, 1442, 1359, 1317, 1237, 1198, 1159cm −1   
               
               
                 I-928 
                 mp 183–185° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.44(t, J=7.5Hz, 3H), 2.27(s, 3H), 2.31(s, 3H), 3.16–3.23(m, 2H), 6.53(d, J=2.4Hz, 1H), 6.78–6.82 
               
               
                   
                 (m, 2H), 7.09(s, 1H), 7.14–7.18(m, 3H), 7.24–7.27(m, 3H), 7.59–7.65(m, 1H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1607, 1527, 1491, 1451, 1436, 1359, 1336, 1271, 1222, 1153, 1110cm −1   
               
               
                 I-929 
                 mp 184–186° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.26(s, 3H), 2.32(s, 3H), 3.01(s, 6H), 6.78–6.83(m, 2H), 7.10(s, 1H), 7.18(s, 1H), 7.23–7.27(m, 1H), 
               
               
                   
                 7.65(dd, J=1.8, 8.1Hz, 1H), 7.70(d, J=2.1Hz, 1H), 8.19–8.24(m, 1H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1721, 1612, 1536, 1490, 1325, 1282, 1242, 1197, 1169, 1123, 1054cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 184 
               
               
                   
               
             
            
               
                 I-930 
                 mp 212–215° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.83(s, 3H), 3.43(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.79(s, 3H), 4.87(s, 2H), 7.08(s, 1H), 7.21(d, J=8.4Hz, 
               
               
                   
                 1H), 7.27–7.32(m, 2H), 7.48(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol) 1731, 1604, 1519, 1480, 1237, 1174, 1081, 1013, 876, 839, 822, 804cm −1   
               
               
                 I-931 
                 mp 166–168° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 4.67(d, J=9.0Hz, 2H), 6.45(s, 1H), 6.78(t, J=9.0Hz, 1H), 6.92(d, J=8.7Hz, 
               
               
                   
                 2H), 6.92(d, J=8.4Hz, 1H), 6.98(dd, J=8.4, 2.1Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol) 3399, 1611, 1588, 1523, 1488, 1460, 1224, 1113, 1070, 1012, 939, 825, 813, 795cm −1   
               
               
                 I-932 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 4.64–4.74(m, 3H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.93(d, J=8.4,Hz, 
               
               
                   
                 1H), 6.97(dd, J=8.4, 2.1Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol) 3570, 3461, 3357, 3180, 1753, 1616, 1596, 1524, 1495, 1408, 1313, 1287, 1264, 1240, 1200, 1114, 1073, 1011, 
               
               
                   
                 906, 825cm −1   
               
               
                 I-933 
                 mp 120–123° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.69(s, 3H), 1.74(s, 6H), 1.80(s, 3H), 3.49(s, 3H), 6.68–3.75(m, 5H), 4.58(d, J=6.6Hz, 2H), 5.31–5.41 
               
               
                   
                 (m, 1H), 5.50–5.56(m, 1H), 5.81(s, 1H), 6.46(s, 1H), 6.68–6.74(m, 2H), 6.85–6.93(m, 3H), 7.50–7.56(m, 2H) 
               
               
                   
                 IR(KBr) 3460, 2969, 2929, 1609, 1523, 1490, 1398, 1247, 1117, 1078, 1013, 824, 778, 708, 589cm −1   
               
               
                 I-934 
                 mp 171–173° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.80(s, 3H), 3.47(s, 3H), 3.73(s, 3H), 3.81(s, 2H), 4.58(d, J=6.9Hz, 2H), 5.50–5.57(m, 
               
               
                   
                 1H), 5.82(s, 1H), 6.44(s, 1H), 6.77–6.94(m, 5H), 7.50–7.55(m, 2H) 
               
               
                   
                 IR(KBr) 3382, 3320, 2929, 1613, 1523, 1490, 1405, 1262, 1221, 1120, 1067, 1011, 844, 818, 598cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 185 
               
               
                   
               
             
            
               
                 I-935 
                 mp 220–221° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.74(s, 3H), 1.77(s, 3H), 2.08(s, 3H), 3.30(s, 3H), 3.64(s, 3H), 4.64(d, J=7.2Hz, 2H), 5.48–5.54 
               
               
                   
                 (m, 1H), 6.40(s, 1H), 6.80–6.87(m, 2H), 6.93–7.03(m, 2H), 7.42–7.46(m, 2H), 7.85(s, 1H), 8.58(s, 1H), 8.96(s, 1H), 9.56(s, 
               
               
                   
                 1H) 
               
               
                   
                 IR(KBr) 3476, 3400, 3322, 2935, 1658, 1610, 1542, 1520, 1487, 1270, 1258, 1225, 1115, 1010, 825, 596cm −1   
               
               
                 I-936 
                 mp 149–150° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.48(s, 3H), 1.67(s, 3H), 1.76(s, 3H), 1.80(s, 3H), 3.63(s, 3H), 3.74(s, 3H), 4.27(d, J=7.5Hz, 2H), 
               
               
                   
                 4.63(d, J=6.6Hz, 2H), 5.01(s, 1H), 5.20–5.28(m, 1H), 5.52–5.60(m, 1H), 6.66(s, 1H), 6.91(d, J=8.7Hz, 2H), 7.01(t, J=8.7Hz, 
               
               
                   
                 1H), 7.10–7.22(m, 2H), 7.48(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3335, 2936, 1671, 1614, 1596, 1522, 1441, 1403, 1369, 1265, 1233, 1111, 1077, 1008, 945, 832cm −1   
               
               
                 I-937 
                 mp 122–123° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.44(s, 3H), 3.76(s, 3H), 4.77(d, J=6.3Hz, 2H), 5.05(s, 1H), 6.04(s, 1H), 6.24(t, J=6.3Hz, 1H), 
               
               
                   
                 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H) 7.01(t, J=8.7Hz, 1H), 7.19–7.30(m, 2H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3582, 3502, 3237, 2950, 1614, 1524, 1490, 1453, 1403, 1301, 13267, 1231, 1112, 1073, 1019, 881, 827cm −1   
               
               
                 I-938 
                 mp 143–144° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.79(s, 3H), 1.84(s, 3H), 2.10(s, 3H), 2.17(s, 3H), 2.47(s, 3H), 3.23(s, 3H), 3.24(s, 3H), 4.66(d, J=6.6Hz, 
               
               
                   
                 2H), 5.20–5.55(m, 1H), 7.09–7.16(m, 4H), 7.40(d, J=8.7Hz, 2H), 7.60(d, J=8.1Hz, 2H) 
               
               
                   
                 IR(KBr) 3433, 2935, 1513, 1472, 1366, 1188, 1178, 1152, 1117, 974, 857cm −1   
               
               
                 I-939 
                 mp 80–81° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.47(s, 3H), 3.48(s, 3H), 3.68(s, 3H), 3.81(s, 6H), 4.79(s, 2H), 5.13(s, 2H), 5.14(s, 2H), 5.65(s, 1H), 
               
               
                   
                 5.75(s, 1H), 6.28(s, 1H), 6.69(s, 2H), 7.01(s, 2H), 7.14(s, 1H), 7.40–7.45(m, 5H) 
               
               
                   
                 IR(KBr) 3433, 2937, 1720, 1582, 1508, 1455, 1407, 1285, 1239, 1125, 1069, 1051, 1011cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 186 
               
               
                   
               
             
            
               
                 I-940 
                 mp 71–72° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.72(s, 3H), 3.78(s, 6H), 4.63(d, J=6.8Hz, 
               
               
                   
                 2H), 5.46–5.52(m, 1H), 6.65(s, 1H), 6.70(d, J=3.8Hz, 2H), 7.07(d, J=8.4Hz, 1H), 7.34–7.46(m, 3H) 
               
               
                   
                 IR(KBr) 3433, 2938, 1674, 1609, 1587, 1518, 14732, 1365, 1252, 1178, 1109, 1077, 971, 945, 815, 796cm −1   
               
               
                 I-941 
                 mp 98–99° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.74(s, 3H), 1.78(s, 3H), 3.50(s, 3H), 3.71(s, 3H), 3.72(d, J=8.1Hz, 2H), 5.35(t, J=7.2Hz, 1H), 
               
               
                   
                 5.64(s, 1H), 5.77(s, 1H), 6.43(s, 1H), 7.02–7.15(m, 3H), 7.32–7.41(m, 2H), 7.49–7.56(m, 1H) 
               
               
                   
                 IR(KBr) 3408, 2934, 1627, 1529, 1491, 1444, 1405, 1246, 1175, 1102, 1069, 822, 783cm −1   
               
               
                 I-942 
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.68(s, 3H), 2.73(s, 3H), 3.25(s, 3H), 3.60(s, 3H), 3.81(s, 3H), 4.65(d, J=6.3Hz, 
               
               
                   
                 2H), 5.44–5.53(m, 1H), 6.87(s, 1H), 7.10(d, J=8.7Hz, 1H), 7.30–7.47(m, 3H), 7.84(d.d, J=7.8 &amp; 2.1Hz, 1H), 
               
               
                   
                 8.22(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr) 1530, 1480, 1362, 1272, 1237, 1179, 1077cm −1   
               
               
                 I-943 
                   1 H NMR(CDCl 3 ) δ 2.69(s, 3H), 3.12(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 3.84(s, 2H), 5.18(s, 2H), 6.82(s, 1H), 6.84(d, J=8.1Hz, 
               
               
                   
                 1H), 7.14(d, J=8.4Hz, 1H), 7.21–7.50(m, 9H) 
               
               
                   
                 IR(KBr) 3466, 3377, 1634, 1583, 1525, 1488, 1461, 1400, 1288, 1245, 1196, 1105, 1069cm −1   
               
               
                 I-944 
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.49(s, 3H), 3.75(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.48–5.57(m, 1H), 5.59–5.75 
               
               
                   
                 (m, 1H), 5.88(s, 1H), 6.43(s, 1H), 6.83–7.07(m, 4H), 7.21–7.30(m, 1H), 7.35(d.d, J=12.3 &amp; 1.8Hz, 2H) 
               
               
                   
                 IR(KBr) 3465, 3377, 1634, 1525, 1488, 1460, 1400, 1287, 1245, 1195, 1105, 1068cm −1   
               
               
                 I-945 
                   1 H NMR(CDCl 3 ) δ 2.02(s, 6H), 2.15(s, 3H), 3.20(s, 3H), 5.20(s, 3H), 6.81–6.86(m, 1H), 6.93(d.d, J=10.7 &amp; 2.1Hz, 1H), 
               
               
                   
                 6.97(s, 1H), 7.04–7.12(m, 1H), 7.31–7.52(m, 9H) 
               
               
                   
                 IR(KBr) 1513, 1468, 1362, 1295, 1264, 1227, 1193, 1171, 1151, 1003, 965cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 187 
               
               
                   
               
             
            
               
                 I-946 
                   1 H NMR(CDCl 3 ) δ 2.02(s, 6H), 2.15(s, 3H), 3.20(s, 3H), 5.14(d, J=3.9Hz, 1H), 6.81–6.86(m, 1H), 6.91(d.d, J=10.1 &amp; 
               
               
                   
                 2.1Hz, 1H), 6.97(s, 1H), 7.04–7.12(m, 1H), 7.30–7.42(m, 4H) 
               
               
                   
                 IR(KBr) 3414, 1624, 1595, 1518, 1473, 1360, 1294, 1170, 1144, 1120, 1104, 1016cm −1   
               
               
                 I-947 
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.02(s, 6H), 2.16(s, 3H), 3.20(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.53–5.61(m, 
               
               
                   
                 1H), 6.82–7.09(m, 4H), 7.33(d, J=9.0Hz, 2H), 7.39(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr) 1514, 1468, 1376, 1294, 1262, 1175, 1152, 992, 968cm −1   
               
               
                 I-948 
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.02(s, 6H), 2.17(s, 3H), 4.64(d, J=6.6Hz, 2H), 4.81(s, 1H), 5.52–5.60(m, 
               
               
                   
                 1H), 6.82–7.08(m, 6H), 7.22(.d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3568, 3417, 1613, 1517, 1471, 1287, 1261, 1230, 1192, 1132, 1102, 1001cm −1   
               
               
                 I-949 
                   1 H NMR(CDCl 3 ) δ 3.02(s, 6H), 3.46(s, 3H), 3.75(s, 3H), 5.18(s, 2H), 6.03(s, 1H), 6.47(s, 1H), 6.82(d, J=8.7Hz, 2H), 
               
               
                   
                 7.03–7.51(m, 8H), 7.55(.d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3502, 1604, 1527, 1488, 1359, 1267, 1233, 1198, 1110, 1070cm −1   
               
               
                 I-950 
                   1 H NMR(CDCl 3 ) δ 2.60(s, 3H), 3.03(s, 6H), 3.54(s, 3H), 3.76(s, 3H), 5.21(s, 2H), 6.80(d, J=8.7Hz, 2H), 6.86(s, 
               
               
                   
                 1H), 7.03–7.49(m, 8H), 7.54(.d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1602, 1530, 1483, 1444, 1395, 1366, 1233, 1179, 1078, 1015cm −1   
               
               
                 I-951 
                   1 H NMR(CDCl 3 ) δ 2.76(s, 3H), 3.02(s, 6H), 3.54(s, 3H), 3.76(s, 3H), 5.28(s, 1H), 6.81(d, J=9.0Hz, 2H), 6.86(s, 1H), 
               
               
                   
                 7.04–7.23(m, 3H), 7.54(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr) 3375, 1607, 1530, 1483, 1395, 1346, 1292, 1228, 1163, 1077, 1009cm −1   
               
               
                 I-952 
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(s, 3H), 2.71(s, 3H), 3.02(s, 6H), 3.55(s, 3H), 3.76(s, 3H), 4.63(d, J=6.9Hz, 2H), 
               
               
                   
                 5.49–5.57(m, 1H), 6.82(.d, J=8.7Hz, 2H), 6.86(s, 1H), 7.01–7.23(m, 3H), 7.54(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1602, 1531, 1484, 1389, 1369, 1258, 1235, 1197, 1176, 1084cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 188 
               
               
                   
               
             
            
               
                 I-953 
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(s, 3H), 3.02(s, 6H), 3.47(s, 3H), 3.75(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.51–5.60(m, 
               
               
                   
                 1H), 6.03(s, 1H), 6.47(s, 1H), 6.82(.d, J=8.7Hz, 2H), 6.99–7.08(m, 1H), 7.16–7.29(m, 2H), 7.55(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3498, 1604, 1528, 1488, 1360, 1266, 1234, 1198, 1110, 1067cm −1   
               
               
                 I-954 
                   1 H NMR(CDCl 3 ) δ 3.02(s, 6H), 3.47(s, 3H), 3.75(s, 3H), 5.14(s, 1H), 6.03(s, 1H), 6.47(s, 1H), 6.82(d, J=9.0Hz, 2H), 
               
               
                   
                 7.02–7.09(m, 1H), 7.15–7.29(m, 2H), 7.55(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr) 3492, 3383, 1607, 1529, 1488, 1397, 1223, 1103, 1065, 1006cm −1   
               
               
                 I-955 
                   1 H NMR(CDCl 3 ) δ 2.01(s, 6H), 2.17(s, 3H), 4.75(s, 1H), 5.19(s, 2H), 6.83–7.15(m, 7H), 7.30–7.53(m, 6H) 
               
               
                   
                 IR(KBr) 3542, 1607, 1579, 1513, 1469, 1263, 1126, 1107, 1015cm −1   
               
               
                 I-956 
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 2.66(s, 3H), 3.50(s, 3H), 3.77(s, 3H), 4.62(d, J=6.4Hz, 2H), 5.48–5.56(m, 
               
               
                   
                 1H), 5.71(s, 1H), 5.81(s, 1H), 5.47(s, 1H), 6.90–7.00(m, 2H), 7.04(d, J=1.8Hz, 1H), 7.42(.d, J=7.8Hz, 2H), 7.82(d.d, J=7.8 
               
               
                   
                 &amp; 1.8Hz, 1H), 8.26(.d, J=1.5Hz, 1H) 
               
               
                   
                 IR(KBr) 3520, 3419, 1585, 1529, 1506, 1344, 1313, 1290, 1251, 1226, 1118, 1079cm −1   
               
               
                 I-957 
                 mp 123–126° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.78(d, J=0.9Hz, 3H), 3.47(s, 3H), 3.75(s, 3H), 3.87(s, 3H), 3.88(s, 3H), 4.63(d, J=6.6Hz, 
               
               
                   
                 2H), 5.57(m, 1H), 5.92(s, 1H), 6.47(s, 1H), 6.95–7.40(m, 5H), 7.56–7.62(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3510, 2934, 1608, 1519, 1489, 1461, 1394, 1285, 1243, 1175, 1115, 1075, 1034, 1008, 926, 823cm −1   
               
               
                 I-958 
                 mp 163–164° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.78(s, 3H), 3.61(s, 3H), 3.65(s, 3H), 3.75(s, 3H), 3.88(s, 3H), 4.64(d, J=6.6Hz, 2H), 
               
               
                   
                 4.99(s, 1H), 5.58(m, 1H), 6.68(s, 1H), 6.88–6.98(m, 5H), 7.46–7.52(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3592, 2934, 1610, 1517, 1461, 1387, 1237, 1171, 1136, 1111, 1084 1036, 1012, 830cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 189 
               
               
                   
               
             
            
               
                 I-959 
                 mp 142–146° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.47(s, 3H), 3.75(s, 3H), 3.94(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.53(m, 1H), 
               
               
                   
                 5.69(s, 1H), 5.70(s, 1H), 5.91(s, 1H), 6.46(s, 1H), 6.94–7.26(m, 6H) 
               
               
                   
                 IR(CHCl 3 ) 3526, 2930, 1585, 1520, 1489, 1460, 1399, 1287, 1260, 1110, 1070, 1010, 819cm −1   
               
               
                 I-960 
                 mp 141–145° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.39(s, 3H), 3.47(s, 3H), 3.94(s, 3H), 5.10(s, 2H), 5.68(s, 1H), 5.69(s, 1H), 5.92(s, 1H), 6.46(s, 1H), 
               
               
                   
                 6.93–7.38(m, 6H) 
               
               
                   
                 IR(CHCl 3 ) 3528, 1585, 1519, 1489, 1460, 1399, 1260, 1110, 1070, 1009, 863cm −1   
               
               
                 I-961 
                 mp 152–154° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.26(s, 3H), 4.79(br, 1H), 5.19(s, 2H), 6.87–6.90(m, 2H), 7.03–7.15(m, 4H), 7.22–7.26(m, 2H), 7.34–7.50 
               
               
                   
                 (m, 6H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 2925, 2869, 1612, 1581, 1523, 1490, 1455, 1383, 1313, 1298, 1259, 1171, 1125, 1100, 1012, 956, 877, 836cm −1   
               
               
                 I-962 
                 mp 150–151° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.28(s, 3H), 3.90(s, 3H), 4.77–4.79(d, J=6.0Hz, 2H), 6.26(d, J=6.0Hz, 1H), 6.88–6.91(m, 5H), 
               
               
                   
                 7.13–7.14(d, J=2.7Hz, 2H), 7.24–7.27(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 2958, 1732, 1612, 1587, 1522, 1490, 1464, 1325, 1257, 1172, 1139, 1100, 1032, 886, 835cm −1   
               
               
                 I-963 
                 mp 93–94° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.27(s, 3H), 4.76–4.79(d, J=6.0Hz, 2H), 5.12(br, 1H), 6.24(t, J=6.0Hz, 1H), 6.88–7.15(m, 7H), 
               
               
                   
                 7.22–7.26(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 2925, 2867, 1613, 1583, 1523, 1490, 1458, 1424, 1388, 1258, 1171, 1126, 1100, 1022, 956, 886, 836cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 190 
               
               
                   
               
             
            
               
                 I-964 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.47(s, 3H), 3.74(s, 3H), 5.06(s, 1H), 5.15(s, 2H), 5.70(s, 1H), 5.94(s, 1H), 6.46(s, 1H), 6.81–7.50(m, 
               
               
                   
                 12H) 
               
               
                   
                 IR(CHCl 3 ) 3534, 1609, 1587, 1518, 1504, 1482, 1463, 1455, 1407, 1322, 1290, 1249, 1200, 1112, 1072, 1011cm −1   
               
               
                 I-965 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.61(s, 3H), 3.75(s, 3H), 5.16(s, 2H), 5.72(s, 2H), 6.46(s, 1H), 6.83(s, 1H), 6.94(dd, J=2.0, 8.4Hz, 
               
               
                   
                 1H), 7.00–7.12(m, 4H), 7.29–7.50(m, 7H) 
               
               
                   
                 IR(CHCl 3 ) 3531, 1587, 1516, 1498, 1482, 1462, 1455, 1410, 1362, 1308, 1288, 1248, 1202, 1121, 1092, 1070, 1006cm −1   
               
               
                 I-966 
                 mp 174–175° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.28(s, 3H), 3.38(s, 3H), 3.71(s, 3H), 5.16(s, 2H), 5.68(s, 1H), 5.88(s, 1H), 6.30(s, 1H), 6.98(dd, J=1.8, 
               
               
                   
                 8.4Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.11(d, J=1.8Hz, 1H), 7.22–7.49(m, 9H) 
               
               
                   
                 IR(KBr) 3516, 3398, 1587, 1516, 1500, 1484, 1453, 1412, 1306, 1285, 1247, 1231, 1202, 1126, 1101, 1072, 1019, 769, 737cm −1   
               
               
                 I-967 
                 mp 103–104° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.26(s, 6H), 4.61–4.78(m, 3H), 4.84(s, 1H), 6.84–6.92(m, 2H), 6.97–7.16(m, 5H), 7.21–7.27(m, 2H) 
               
               
                   
                 IR(KBr) 3409, 1742, 1523, 1489, 1315, 1295, 1259, 1231, 1206, 1193, 1124, 1001, 834, 815cm −1   
               
               
                 I-968 
                 mp 90–91° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 6H), 1.82(d, J=0.9Hz, 6H), 2.27(s, 6H), 4.56(d, J=6.6Hz, 2H), 5.13(d, J=6.6Hz, 2H), 
               
               
                   
                 5.49–5.60(m, 2H), 6.94–7.00(m, 2H), 7.01–7.14(m, 5H), 7.25–7.31(m, 2H) 
               
               
                   
                 IR(KBr) 1608, 1522, 1488, 1378, 1299, 1288, 1273, 1259, 1242, 1196, 1176, 1014, 831, 811, 776cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 191 
               
               
                   
               
             
            
               
                 I-969 
                 mp 200–203° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.00(s, 3H), 2.25(s, 3H), 3.46(s, 3H), 3.73(s, 3H), 3.83(s, 3H), 5.25(s, 1H), 6.01–6.03(m, 1H), 6.06(s, 
               
               
                   
                 1H), 6.45(s, 1H), 6.86–6.90(m, 2H), 7.04–7.14(m, 3H), 7.47–7.52(m, 2H) 
               
               
                   
                 IR(KBr) 3433, 2937, 1721, 1651, 1523, 1489, 1398, 1264, 1225, 1136, 1071, 1035, 927, 823, 530cm −1   
               
               
                 I-970 
                 mp 157–160° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.74(s, 3H), 1.80(s, 3H), 2.86(s, 3H), 3.49(s, 3H), 3.75(s, 3H), 4.57(d, J=6.6Hz, 2H), 5.08(s, 1H), 
               
               
                   
                 5.50–5.57(m, 1H), 5.82(s, 1H), 6.46(s, 1H), 6.66(d, J=2.1Hz, 1H), 6.73(dd, J=2.1, 8.1Hz, 1H), 6.86–6.94(m, 3H), 7.50–7.56 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(KBr) 3392, 2934, 1611, 1523, 1490, 1397, 1242, 1216, 1112, 1074, 1002, 592cm −1   
               
               
                 I-971 
                 mp 153–155° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.10(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.36(s, 3H), 3.71(s, 3H), 4.63(d, J=6.9Hz, 
               
               
                   
                 2H), 5.52(t, J=6.9Hz, 1H), 6.73(s, 1H), 7.06(d, J=8.4Hz, 1H), 7.14(dd, J=8.4, 2.1Hz, 1H), 7.23(d, J=2.1Hz, 
               
               
                   
                 1H), 7.36(d, J=8.9Hz, 2H), 7.69(d, J=8.9Hz, 2H) 
               
               
                   
                 IR(KBr) 1515, 1474, 1365, 1229, 1175, 1151, 1096, 973, 870, 810cm −1   
               
               
                 I-972 
                 amorphous 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.43(s, 3H), −3.44(s, 3H), 3.71(s, 3H), 4.49(d, J=9.9Hz, 2H), 4.62(d, J=6.6Hz, 
               
               
                   
                 2H), 4.72(d, J=7.2Hz, 2H), 5.53(t, J=6.6Hz, 1H), 6.86(s, 1H), 6.96(d, J=8.7Hz, 1H), 7.21–7.30(m, 4H), 7.54(d, J=8.1Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3599, 1463, 1386, 1081, 1007cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 192 
               
               
                   
               
             
            
               
                 I-973 
                 mp 83–86° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.74(s, 3H), 1.77(s, 3H), 3.36(s, 3H), 3.65(s, 3H), 4.23(d, J=23.1Hz, 2H), 4.48(t, J=4.4Hz, 
               
               
                   
                 1H), 4.52(d, J=5.4Hz, 2H), 4.52–4.60(m, 4H), 4.89(t, J=5.6Hz, 1H), 5.22(t, J=5.9Hz, 1H), 5.48(t, J=6.6Hz, 1H), 6.92 
               
               
                   
                 (s, 1H), 6.96(d, J=8.6Hz, 1H), 7.12(dd, J=8.6, 1.5Hz, 1H), 7.26(d, J=1.5Hz, 1H), 7.42(d, J=8.0Hz, 2H), 7.61(d, J=8.0Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3399, 1464, 1386, 1230, 1005cm −1   
               
               
                 I-974 
                 mp 177–179° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.31(d, J=6.9Hz, 6H), 2.70(s, 3H), 2.98(sept, J=6.9Hz, 1H), 3.12(s, 3H), 3.54(s, 3H), 3.76(s, 3H), 
               
               
                   
                 5.19(s, 2H), 6.87(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.30–7.49(m, 9H), 7.54(d, J=7.8Hz, 2H) 
               
               
                   
                 IR(KBr) 1512, 1480, 1369, 1176, 1084, 1014, 813, 798cm −1   
               
               
                 I-975 
                 mp 180–182° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.31(d, J=6.6Hz, 6H), 1.76(s, 3H), 1.81(s, 3H), 2.74(s, 3H), 2.98(sept, J=6.6Hz, 1H), 3.22(s, 3H), 
               
               
                   
                 3.54(s, 3H), 3.77(s, 3H), 4.63(d, J=6.7Hz, 2H), 5.49(t, J=6.7Hz, 1H), 6.87(s, 1H), 7.08(d, J=8.4Hz, 1H), 7.31(d, J=8.1Hz, 
               
               
                   
                 2H), 7.35(dd, J=8.4, 2.1Hz, 1H), 7.40(d, J=2.1Hz, 1H), 7.54(d, J=8.1Hz, 2H) 
               
               
                   
                 IR(KBr) 1520, 1481, 1366, 1177, 1083, 1012, 975, 944, 815, 797cm −1   
               
               
                 I-976 
                 mp 125–126° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.31(d, J=6.9Hz, 6H), 1.76(s, 3H), 1.82(s, 3H), 2.97(sept, J=6.9Hz, 1H), 3.46(s, 3H), 3.74(s, 3H), 
               
               
                   
                 4.61(d, J=7.1Hz, 2H), 5.53(t, J=7.1Hz, 1H), 5.68(s, 1H), 5.91(s, 1H), 6.48(s, 1H), 6.95–6.96(m, 2H), 7.06–7.07(m, 1H), 
               
               
                   
                 7.31(d, J=8.0Hz, 2H), 7.57(d, J=8.0Hz, 2H) 
               
               
                   
                 IR(KBr)cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 193 
               
               
                   
               
             
            
               
                 I-977 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.68(s, 3H), 3.13(s, 3H), 3.20(s, 3H), 3.57(s, 3H), 3.79(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.15(d, J=8.7Hz, 
               
               
                   
                 1H), 7.31–7.62(m, 11H) 
               
               
                   
                 IR(CHCl 3 ) 1517, 1475, 1371, 1227, 1219, 1176, 1117, 1081, 968, 925, 856, 821cm −1   
               
               
                 I-978 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.65(s, 3H), 2.94(s, 3H), 3.14(s, 3H), 3.59(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.16(d, J=8.7Hz, 
               
               
                   
                 1H), 7.33–7.57(m, 11H) 
               
               
                   
                 IR(CHCl 3 ) 1517, 1477, 1398, 1370, 1268, 1233, 1216, 1177, 1159, 1079, 972, 894, 856, 818cm −1   
               
               
                 I-979 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.69(s, 3H), 2.94(s, 3H), 3.25(s, 3H), 3.60(s, 3H), 3.76(s, 3H), 4.64(d, J=6.9Hz, 
               
               
                   
                 2H), 5.50(m, 1H), 6.86(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.34–7.57(m, 11H) 
               
               
                   
                 IR(CHCl 3 ) 1517, 1476, 1398, 1369, 1234, 1178, 1159, 1105, 1079, 972, 895, 854, 814, 801cm −1   
               
               
                 I-980 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(d, J=0.9Hz, 3H), 1.81(d, J=0.9Hz, 3H), 2.71(s, 3H), 3.20(s, 3H), 3.24(s, 3H), 3.57(s, 3H), 
               
               
                   
                 3.79(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.49(m, 1H), 6.86(s, 1H), 7.09(d, J=8.7Hz, 1H), 7.31–7.40(m, 3H), 7.48–7.55(m, 3H) 
               
               
                   
                 IR(CHCl 3 ) 1517, 1474, 1365, 1269, 1236, 1177, 1140, 1116, 1078, 964, 923, 854, 814cm −1   
               
               
                 I-981 
                 mp 122–123° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(d, J=0.4Hz, 3H), 3.62(s, 3H), 3.75(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.53(m, 1H), 
               
               
                   
                 5.70(s, 1H), 5.73(s, 1H), 6.46(s, 1H), 6.86(s, 1H), 6.89–7.13(m, 4H), 7.29–7.46(m, 3H) 
               
               
                   
                 IR(KBr) 3366, 1587, 1496, 1482, 1462, 1449, 1408, 1371, 1313, 1290, 1245, 1210, 1126, 1093, 1073, 1001, 783, 770cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 194 
               
               
                   
               
             
            
               
                 I-982 
                 mp 171–172° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.48(s, 3H), 3.74(s, 3H), 4.61(d, J=6.9Hz, 2H), 4.91(s, 1H), 5.53(m, 1H), 
               
               
                   
                 5.70(s, 1H), 5.91(s, 1H), 6.46(s, 1H), 6.86(m, 1H), 6.91–7.02(m, 2H), 7.06(m, 1H), 7.13(m, 1H), 7.21(m, 1H), 7.32(m, 
               
               
                   
                 1H) 
               
               
                   
                 IR(KBr) 3368, 1585, 1519, 1507, 1484, 1460, 1450, 1403, 1294, 1255, 1237, 1206, 1110, 1072, 1006, 789, 766cm −1   
               
               
                 I-983 
                 mp 92.5–93° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.83(d, J=0.9Hz, 3H), 2.26(s, 3H), 2.27(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.13(d, J=3.9Hz, 
               
               
                   
                 1H), 5.55(m, 1H), 6.98–7.14(m, 8H) 
               
               
                   
                 IR(CHCl 3 ) 3578, 2922, 1618, 1522, 1490, 1383, 1282, 1120, 979, 873, 824cm −1   
               
               
                 I-984 
                 mp 89–95° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 6H), 1.81(d, J=0.9Hz, 6H), 2.27(s, 6H), 4.63(d, J=6.6Hz, 4H), 5.55(m, 2H), 6.98–7.14(m, 
               
               
                   
                 8H) 
               
               
                   
                 IR(CHCl 3 ) 2930, 1576, 1520, 1490, 1382, 1296, 1270, 1127, 987, 874cm −1   
               
               
                 I-985 
                 mp 74–75° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.16(s, 3H), 2.69(s, 3H), 3.14(s, 3H), 3.20(s, 3H), 3.56(s, 3H), 5.20(s, 2H), 7.16–7.49(m, 11H), 7.65–7.68 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 2939, 1732, 1613, 1518, 1478, 1454, 1415, 1371, 1331, 1292, 1268, 1176, 1150, 1118, 1088, 1010, 969, 950, 872cm −1   
               
               
                 I-986 
                 mp 50–52° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.16(s, 3H), 2.74(s, 3H), 3.20(s, 3H), 3.24(s, 3H), 3.57(s, 3H), 4.64–4.66(d, 
               
               
                   
                 J=6.3Hz, 2H), 5.50(m, 1H), 7.10–7.39(m, 6H), 7.66–7.68(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 2938, 1613, 1518, 1477, 1370, 1331, 1290, 1267, 1176, 1150, 1117, 1088, 970, 949, 871cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 195 
               
               
                   
               
             
            
               
                 I-987 
                   1 H NMR(CDCl 3 ) δ 1.59–1.60(d, J=0.6Hz, 3H), 1.70–1.71(d, J=0.9Hz, 3H), 2.26(s, 3H), 2.28(s, 3H), 2.36(m, 1H), 2.77 
               
               
                   
                 (m, 1H), 3.20(s, 3H), 3.23(s, 3H), 5.24(m, 1H), 7.12(s, 1H), 7.15(s, 1H), 7.23–7.25(m, 1H), 7.33–7.42(m, 6H) 
               
               
                 I-988 
                 mp 159–161° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 2.12(s, 3H), 3.48(s, 3H), 4.61–4.64(d, J=6.6Hz, 2H), 4.75(br, 1H), 5.54(m, 
               
               
                   
                 1H), 5.69(s, 1H), 5.73(s, 1H), 6.77–6.98(m, 6H), 7.51–7.54(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3595, 3529, 2937, 1613, 15787, 1522, 1489, 1455, 1401, 1310, 1289, 1173, 1127, 1095, 1009, 939, 835cm −1   
               
               
                 I-989 
                 mp 126–128° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.25(s, 3H), 3.78(s, 3H), 5.16(s, 2H), 5.75(br, 1H), 6.83–6.89(m, 4H), 6.98–7.00(m, 2H), 7.17(s, 1H), 
               
               
                   
                 7.40–7.47(m, 7H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 3543, 2937, 1610, 1588, 1523, 1493, 1465, 1455, 1388, 1328, 1315, 1262, 1173, 1126, 1038, 1012, 835cm −1   
               
               
                 I-990 
                 mp 87–90° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.59–1.60(d, J=0.6Hz, 3H), 1.72–1.73(d, J=0.9Hz, 3H), 2.26(s, 3H), 2.28(s, 3H), 2.34–2.37(m, 2H), 
               
               
                   
                 2.66–2.71(m, 2H), 4.84–4.86(br, 2H), 5.28(m, 1H), 6.79(d, J=1.5Hz, 1H), 6.86–6.89(m, 3H), 7.11–7.17(m, 3H), 7.23–7.26 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3598, 2925, 2859, 1612, 1569, 1521, 1488, 1450, 1425, 1414, 1328, 1257, 1171, 1101, 958, 836cm −1   
               
               
                 I-991 
                 mp 174–176° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.26(s, 3H), 3.13(s, 3H), 3.18(s, 3H), 3.80(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 7.13(d, J=8.4Hz, 1H), 
               
               
                   
                 7.18(s, 1H), 7.28–7.50(m, 9H), 7.59–7.62(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 2940, 1732, 1613, 1520, 1490, 1465, 1455, 1415, 1371, 1331, 1291, 1260, 1173, 1149, 1111, 1038, 1018, 1003, 
               
               
                   
                 971, 872, 813cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 196 
               
               
                   
               
             
            
               
                 I-992 
                 mp 135–137° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77–1.78(d, J=0.9Hz, 3H), 1.82–1.83(d, J=0.6Hz, 3H), 2.26(s, 3H), 3.18(s, 3H), 3.24(s, 3H), 3.80 
               
               
                   
                 (s, 3H), 4.64(d, J=6.6Hz, 2H), 5.52(m, 1H), 6.84(s, 1H), 7.07(d, J=8.7Hz, 1H), 7.18(s, 1H), 7.25–7.35(m, 4H), 7.59–7.62 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 3539, 2937, 1610, 1587, 1523, 1492, 1464, 1454, 1388, 1328, 1315, 1292, 1261, 1173, 1126, 1038, 996, 834cm −1   
               
               
                 I-993 
                 mp 131–133° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.83(s, 3H), 2.26(s, 3H), 3.78(s, 3H), 4.61–4.64(d, J=6.9Hz, 2H), 5.17(br, 1H), 5.35(m, 
               
               
                   
                 1H), 5.78(br, 1H), 6.83–6.99(m, 6H), 7.17(s, 1H), 7.44–7.47(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 3539, 2937, 1610, 1587, 1523, 1492, 1464, 1454, 1388, 1328, 131, 1292, 1261, 1173, 1126, 1038, 996, 834cm −1   
               
               
                 I-994 
                 mp 127–130° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.73(d, J=0.9Hz, 3H), 1.76(d, J=0.9Hz, 3H), 2.99(s, 6H), 3.73–3.76(m, 2H), 3.78(s, 6H), 3.88(s, 
               
               
                   
                 3H), 5.37–5.40(m, 1H), 5.83(d, J=7.8Hz, 1H), 6.78–6.84(m, 2H), 6.95(s, 1H), 6.96(s, 1H), 7.06–7.12(m, 2H), 7.48–7.53(m, 
               
               
                   
                 2H) 
               
               
                 I-995 
                 mp 91–93° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.78(s, 3H), 1.84(s, 3H), 2.02(s, 6H), 4.63(d, J=6.4Hz, 2H), 5.07(s, 1H), 5.15(s, 1H), 5.55(t, J=7.0Hz, 
               
               
                   
                 1H),6.63(dd, J=2.0, 8.2Hz, 1H), 6.77(d, J=2.0Hz, 1H), 6.93–6.99(m, 4H), 7.39(d, J=8.6Hz, 2H) 
               
               
                   
                 IR(KBr) 3423, 2921, 1611, 1518, 1474, 1282, 1244, 1205, 1125, 1089, 995, 837, 815, 785cm −1   
               
               
                 I-996 
                 mp 185-186° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.32(t, J=7.5Hz, 3H), 2.71(q, J=7.5Hz, 2H), 3.46(s, 3H), 3.76(s, 3H), 5.15(s, 2H), 5.69(s, 1H), 
               
               
                   
                 5.89(s, 1H), 6.94–7.08(m, 3H), 7.37–7.46(m, 5H), 7.54–7.59(m, 2H), 7.82(brs, 1H), 7.93(d, J=8.1Hz, 1H) 
               
               
                   
                 IR(KBr) 3504, 3269, 2968, 2936, 1708, 1532, 1518, 1487, 1311, 1286, 1193, 1121, 1071, 1014cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 197 
               
               
                   
               
             
            
               
                 I-997 
                 mp 77–78° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.73(s, 3H), 1.77(s, 3H), 1.82(s, 3H), 2.70(s, 3H), 3.25(s, 3H), 3.55(s, 3H), 3.82(s, 3H), 4.65(d, J=6.9Hz, 
               
               
                   
                 2H), 4.94(d, J=7.5Hz, 2H), 5.31(t, J=8.7Hz, 1H), 5.50(t, J=6.6Hz, 1H), 6.87(s, 1H), 7.10(d, J=8.4Hz, 1H), 
               
               
                   
                 7.28–7.39(m, 3H), 7.87(d, J=8.1Hz, 1H), 7.99(s, 1H) 
               
               
                   
                 IR(KBr) 3431, 2939, 1702, 1518, 1483, 1368, 1308, 1204, 1177, 1121, 1092, 1079, 957, 804cm −1   
               
               
                 I-998 
                 mp 144–145° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.48(s, 3H), 3.69(s, 3H), 3.80(s, 6H), 4.61(d, J=6.9Hz, 2H), 5.51(t, J=4.8Hz, 
               
               
                   
                 1H), 5.66(brs, 1H), 5.76(brs, 1H), 6.30(s, 1H), 6.69(d, J=8.1Hz, 2H), 6.93–7.01(m, 2H), 7.11(d, J=2.1Hz, 1H), 
               
               
                   
                 7.31–7.37(m, 1H) 
               
               
                   
                 IR(KBr) 3476, 2936, 1589, 1517, 1500, 1472, 1408, 1288, 1249, 1111cm −1   
               
               
                 I-999 
                 mp 82–83° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.71(s, 3H), 3.15(s, 3H), 3.48(s, 3H), 3.56(s, 3H), 3.72(s, 3H), 3.80(s, 6H), 4.66(s, 2H), 4.79(s, 2H), 
               
               
                   
                 5.19(s, 2H), 6.69(s, 1H), 7.14–7.17(m, 1H), 7.36–7.49(m, 8H) 
               
               
                   
                 IR(KBr) 3434, 2939, 1719, 1613, 1581, 1508, 1463, 1396, 1365, 1294, 1272, 1238, 1177, 1122, 1078, 814cm −1   
               
               
                 I-1000 
                 mp 85–86° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.31(t, J=7.5Hz, 3H), 2.66(s, 3H), 2.71(q, J=7.6Hz, 2H), 3.13(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 
               
               
                   
                 5.19(s, 2H), 6.85(s, 1H), 7.15(d, J=8.8Hz, 1H), 7.33–7.59(m, 4H), 7.85(brs, 1H), 7.94(d, J=8.4Hz, 1H) 
               
               
                   
                 IR(KBr) 3432, 2939, 1727, 1519, 1480, 1365, 1237, 1165, 1079, 959, 803cm −1   
               
               
                 I-1001 
                 mp 105–106° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 6H), 1.79(s, 3H), 1.82(s, 3H), 3.49(s, 3H), 3.75(s, 3H), 3.81(d, J=6.6Hz, 2H), 4.62(d, J=7.2Hz, 
               
               
                   
                 2H), 5.37(t, J=6.3Hz, 1H), 5.53(t, J=6.9Hz, 1H), 5.68(brs, 1H), 5.87(brs, 1H), 6.82(d, J=8.4Hz, 1H), 6.95(s, 2H), 
               
               
                   
                 7.05(s, 1H), 7.26(s, 1H), 7.69(dd, J=2.1, 8.4Hz, 1H), 7.75(brs, 1H) 
               
               
                   
                 IR(KBr) 3459, 2934, 1622, 1582, 1525, 1493, 1467, 1327, 1240, 1139, 1113, 1070, 817cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 198 
               
               
                   
               
             
            
               
                 I-1002 
                 mp 89–91° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.70(s, 3H), 3.12(s, 3H), 3.55(s, 3H), 3.71(s, 3H), 3.79(s, 6H), 4.77(s, 2H), 5.18(s, 2H), 6.69(s, 2H), 
               
               
                   
                 7.14(d, J=8.8Hz, 1H), 7.38–7.52(m, 8H) 
               
               
                   
                 IR(KBr) 3440, 2939, 1721, 1612, 1581, 1508, 1463, 1395, 1364, 1238, 1178, 1120, 1078, 962, 814, 523cm −1   
               
               
                 I-1003 
                 mp 196–197° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.26(s, 3H), 3.48(s, 3H), 3.76(s, 3H), 5.16(s, 2H), 5.69(brs, 1H), 5.83(brs, 1H), 6.44(s, 1H), 6.93–7.05 
               
               
                   
                 (m, 4H), 7.26–7.45(m, 6H), 7.84(d, J=8.1Hz, 1H), 7.92(s, 1H), 8.29(brs, 1H) 
               
               
                   
                 IR(KBr) 3407, 2934, 1672, 1589, 1524, 1459, 1425, 1400, 1316, 1288, 1213, 1119, 1057, 1006, 745cm −1   
               
               
                 I-1004 
                 mp 80–81° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.29(t, J=7.5Hz, 3H), 1.72(s, 3H), 1.76(s, 6H), 1.81(s, 3H), 2.70(s, 3H), 2.71(q, J=7.5Hz, 2H), 
               
               
                   
                 3.24(s, 3H), 3.50(s, 3H), 3.81(s, 3H), 4.64(d, J=6.3Hz, 2H), 4.72–4.76(m, 2H), 5.31(t, J=6.9Hz, 1H), 5.50(t, J=6.3Hz, 
               
               
                   
                 1H), 6.87(s, 1H), 7.08–7.12(m, 2H), 7.34–7.41(m, 3H), 7.61(s, 1H) 
               
               
                   
                 IR(KBr) 3434, 2974, 2938, 1694, 1517, 1480, 1366, 1237, 1202, 1177, 1080, 972, 807, 523cm −1   
               
               
                 I-1005 
                 mp 157–158° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.31(t, J=7.8Hz, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 2.71(q, J=7.8Hz, 2H), 3.24(s, 3H), 
               
               
                   
                 3.55(s, 3H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.50(t, J=8.1Hz, 2H), 6.85(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.33–7.38(m, 
               
               
                   
                 2H), 7.52(d, J=8.1Hz, 1H), 7.58(s, 1H), 7.84(brs, 1H), 7.94(d, J=8.1Hz, 1H) 
               
               
                   
                 IR(KBr) 3434, 3350, 2938, 1727, 1523, 1480, 1368, 1248, 1178, 1165, 1080, 972, 816, 802, 522cm −1   
               
               
                 I-1006 
                 mp 91–93° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.30(t, J=7.5Hz, 3H), 1.75(s, 6H), 1.79(s, 3H), 1.81(s, 3H), 2.55(q, J=7.5Hz, 2H), 3.48(s, 3H), 
               
               
                   
                 3.74(s, 3H), 3.79(d, J=6.3Hz, 2H), 4.61(d, J=6.6Hz, 2H), 5.41(t, J=6.0Hz, 1H), 5.53(t, J=6.9Hz, 1H), 5.67(brs, 1H), 
               
               
                   
                 5.94(brs, 1H), 6.48(s, 1H), 6.72(d, J=8.4Hz, 1H), 6.95(s, 2H), 7.07(s, 1H), 7.37–7.45(m, 2H), 7.64(d, J=7.5Hz, 1H),. 
               
               
                   
                 IR(KBr) 3433, 2932, 1609, 1521, 1489, 1461, 13958, 1308, 1286, 1245, 1192, 1114, 1072, 1011, 811cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 199 
               
               
                   
               
             
            
               
                 I-1007 
                 mp 71–72° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.31(t, J=7.5Hz, 3H), 1.76(s, 3H), 1.82(s, 3H), 2.60(q, J=7.2Hz, 2H), 3.47(s, 3H), 3.75(s, 3H), 
               
               
                   
                 4.61(d, J=6.6Hz, 2H), 5.53(t, J=6.9Hz, 2H), 5.69(brs, 1H), 5.93(brs, 1H), 6.47(s, 1H), 6.78(d, J=8.1Hz, 1H), 6.95(s, 
               
               
                   
                 2H), 7.06(s, 1H), 7.26(s, 1H), 7.39(s, 1H) 
               
               
                   
                 IR(KBr) 3436, 2932, 1620, 1584, 1519, 1487, 1459, 1397, 1285, 1242, 1112, 1072, 819cm −1   
               
               
                 I-1008 
                 mp 171–173° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.46(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 5.88(s, 1H), 6.44(s, 1H), 6.95(dd, J=8.4, 1.9Hz, 
               
               
                   
                 1H), 7.03(d, J=8.4Hz, 1H), 7.08(d, J=1.9Hz, 1H), 7.37–7.48(m, 7H), 7.59(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 3544, 3514, 3462, 1517, 1482, 1388, 1284, 1247, 1089, 1107, 1069, 1006, 938, 822cm −1   
               
               
                 I-1009 
                 mp 180–182° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.68(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 5.19(s, 2H), 6.83(s, 1H), 7.15(d, J=8.4Hz, 1H), 
               
               
                   
                 7.32–7.49(m, 9H), 7.57(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1518, 1478, 1370, 1177, 1085, 1012, 813, 797cm −1   
               
               
                 I-1010 
                 mp 128–130° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 4.62(d, J=7.0Hz, 2H), 5.53(t, J=7.0Hz, 1H), 
               
               
                   
                 5.69(s, 1H), 5.85(s, 1H), 6.44(s, 1H), 6.93(dd, J=8.4, 1.6Hz, 1H), 6.97(d, J=8.4Hz, 1H), 7.05(d, J=1.6Hz, 1H), 7.42(d, 
               
               
                   
                 J=8.4Hz, 2H), 7.59(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 1517, 1482, 1287, 1244, 1106, 1070, 1013, 822, 783cm −1   
               
               
                 I-1011 
                 mp 138–140° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.72(s, 3H), 3.23(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 4.64(d, J=6.5Hz, 2H), 
               
               
                   
                 5.49(t, J=6.5Hz, 1H), 6.83(s, 1H), 7.09(d, J=8.3Hz, 1H), 7.34(dd, J=8.3, 2.0Hz, 1H), 7.39(d, J=2.0Hz, 1H), 7.43(d, 
               
               
                   
                 J=8.6Hz, 2H), 7.57(d, J=8.6Hz, 2H) 
               
               
                   
                 IR(KBr) 1518, 1478, 1369, 1177, 1083, 972, 814, 795cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 200 
               
               
                   
               
             
            
               
                 I-1012 
                 mp 135–138° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.55–1.63(m, 2H), 1.77(s, 6H), 1.83(s, 6H), 4.56(d, J=6.6Hz, 4H), 4.66(d, J=4.5Hz, 4H), 5.50–5.58 
               
               
                   
                 (m, 2H), 6.96–7.01(m, 4H), 7.32–7.38(m, 4H), 7.45(s, 2H) 
               
               
                   
                 IR(KBr) 3339, 2914, 1609, 1520, 1488, 1385, 1289, 1238, 1177, 1000, 834, 651cm −1   
               
               
                 I-1013 
                 mp 202–205° C. 
               
               
                   
                   1 H NMR(CDCl 3  + CD3OD) δ 1.78(s, 3H), 1.82(s, 3H), 4.57(d, J=6.6Hz, 2H), 4.62(s, 4H), 5.50–5.56(m, 1H), 6.86–7.00 
               
               
                   
                 (m, 4H), 7.24–7.37(m, 4H), 7.44(s, 2H) 
               
               
                   
                 IR(KBr) 3399, 2974, 2930, 1610, 1522, 1489, 1438, 1383, 1238, 1176, 999, 903, 838, 538cm −1   
               
               
                 I-1014 
                 mp 219–221° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.22(s, 3H), 2.69(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.15(d, J=8.4Hz, 
               
               
                   
                 1H), 7.32–7.49(m, 7H), 7.60(s, 4H) 
               
               
                   
                 IR(KBr) 3384, 1701, 1604, 1524, 1482, 1355, 1294, 1176, 1084, 1011, 945, 818cm −1   
               
               
                 I-1015 
                 mp 173–175° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.74(s, 3H), 1.77(s, 3H), 2.08(s, 3H), 2.87(s, 3H), 3.35(s, 3H), 3.47(s, 3H), 3.77(s, 3H), 4.68(d, J=6.4Hz, 
               
               
                   
                 2H), 5.48(t, J=6.4Hz, 1H), 7.02(s, 1H), 7.26–7.29(m, 3H), 7.57(d, J=8.7Hz, 2H), 7.70(d, J=8.7Hz, 2H), 10.07 
               
               
                   
                 (s, 1H) 
               
               
                   
                 IR(KBr) 3383, 1704, 1235, 1524, 1481, 1360, 1177, 1083, 976, 816cm −1   
               
               
                 I-1016 
                 mp 144–145° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.70(s, 3H), 3.21(s, 3H), 3.52(s, 3H), 3.69(d, J=1.6Hz, 3H), 4.65(d, J=6.8Hz, 
               
               
                   
                 2H), 5.53(t, J=6.8Hz, 1H), 7.08(t, J=8.4Hz, 1H), 7.16(dd, J=8.4, 1.8Hz, 1H), 7.20(dd, J=11.7, 1.8Hz, 1H), 7.41 
               
               
                   
                 (d, J=8.8Hz, 2H), 7.59(dd, J=8.8, 1.4Hz, 2H) 
               
               
                   
                 IR(KBr) 1521, 1470, 1368, 1265, 1177, 1151, 1038, 971, 875cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 201 
               
               
                   
               
             
            
               
                 I-1017 
                 mp 196–198° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.76(s, 3H), 2.07(s, 3H), 3.31(s, 3H), 3.65(s, 3H), 4.55(d, J=6.6Hz, 2H), 5.49(t, J=6.6Hz, 
               
               
                   
                 1H), 6.43(s, 1H), 6.65(dd, J=8.4, 1.9Hz, 1H), 6.73(d, J=1.9Hz, 1H), 6.90(d, J=8.4Hz, 1H), 7.55(d, J=8.6Hz, 
               
               
                   
                 2H), 7.66(d, J=8.6Hz, 2H), 8.58(br s, 1H), 8.70(br s, 1H), 10.02(s, 1H) 
               
               
                   
                 IR(KBr) 3358, 1661, 1596, 1523, 1489, 1396, 1308, 1254, 1227, 1114, 1074cm −1   
               
               
                 I-1018 
                 mp 141–143° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 3.40(s, 3H), 3.64(d, J=0.9Hz, 3H), 4.64(d, J=6.9Hz, 2H), 4.89(s, 1H), 
               
               
                   
                 5.56(t, J=6.9Hz, 1H), 5.70(s, 1H), 6.94(d, J=8.7Hz, 2H), 7.06(t, J=8.7Hz, 1H), 7.21(ddd, J=8.4, 2.1, 1.1Hz, 1H), 
               
               
                   
                 7.27(dd, J=12.3, 2.1Hz, 1H), 7.44(dd, J=8.7, 1.5Hz, 2H) 
               
               
                   
                 IR(KBr) 3485, 1523, 1466, 1402, 1266, 1173, 1036, 961, 918, 837, 814cm −1   
               
               
                 I-1019 
                 mp 81–82° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.26(s, 3H), 2.72(s, 3H), 3.23(s, 3H), 3.57(s, 3H), 3.79(s, 3H), 4.64(d, J=6.3Hz, 
               
               
                   
                 2H), 5.49(t, J=6.3Hz, 1H), 6.83(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.33–7.39(m, 2H), 7.48(s, 1H), 7.82(d, J=6.0Hz, 
               
               
                   
                 1H), 7.88(s, 1H), 8.32(brs, 1H) 
               
               
                   
                 IR(KBr) 3382, 2939, 1736, 1520, 1483, 1365, 1293, 1178, 1119, 1078, 958, 802, 521cm −1   
               
               
                 I-1020 
                 mp 93–94° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.62(s, 3H), 2.99(s, 3H), 3.15(s, 3H), 3.20(s, 3H), 3.83(s, 3H), 5.21(s, 2H), 6.91(s, 2H), 7.17(d, J=8.2Hz, 
               
               
                   
                 1H), 7.35–7.48(m, 8H), 7.63(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 3434, 3033, 2938, 1611, 1520, 1479, 1366, 1179, 1151, 1085, 969, 850, 793, 519cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 202 
               
               
                   
               
             
            
               
                 I-1021 
                 mp 74–75° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 4.61(d, J=6.3Hz, 2H), 5.53(t, J=5.4Hz, 1H), 
               
               
                   
                 5.69(brs, 1H), 5.86(brs, 1H), 6.42(s, 1H), 6.83(d, J=8.7Hz, 1H), 6.91–6.98(m, 2H), 7.04(s, 1H), 7.62(d, J=8.7Hz, 1H), 
               
               
                   
                 7.73(s, 1H) 
               
               
                   
                 IR(KBr) 3495, 3398, 2935, 1633, 1522, 1487, 1291, 1246, 1112, 1072, 821, 788cm −1   
               
               
                 I-1022 
                 mp 76–77° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 1.84(s, 3H), 3.52(s, 3H), 3.78(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.53(t, J=6.6Hz, 
               
               
                   
                 1H), 5.74(brs, 1H), 5.80(brs, 1H), 6.47(s, 1H), 6.92–7.00(m, 2H), 7.04(s, 1H), 7.38(d, J=8.1Hz, 1H), 7.93(d, J=8.1Hz, 
               
               
                   
                 1H), 8.04(s, 1H) 
               
               
                   
                 IR(KBr) 3411, 2934, 1662, 1519, 1488, 1425, 1309, 1245, 1175, 1128, 1071, 1050cm −1   
               
               
                 I-1023 
                 mp 81–82° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.66(s, 3H), 2.99(s, 3H), 3.18(s, 3H), 3.25(s, 3H), 3.82(s, 3H), 4.64(d, J=6.6Hz, 
               
               
                   
                 2H), 5.49(t, J=6.0Hz, 1H), 6.90(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.38–7.43(m, 3H), 7.62(d, J=8.8Hz, 1H), 8.02(s, 
               
               
                   
                 1H) 
               
               
                   
                 IR(KBr) 3434, 3027, 2938, 1672, 1611, 1520, 1479, 1365, 1179, 1117, 1074, 970, 847, 793, 519cm −1   
               
               
                 I-1024 
                 mp 77–79° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.78(s, 3H), 1.83(s, 3H), 3.77(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.53(t, J=6.2Hz, 1H), 5.76(brs, 2H), 
               
               
                   
                 6.52(s, 1H), 6.91–7.02(m, 6H), 7.46(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 3465, 2935, 1613, 1586, 1524, 1487, 1359, 1282, 1245, 1222, 1173, 1157, 1112, 1065, 974, 857, 521cm −1   
               
               
                 I-1025 
                 mp 78–79° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.73(s, 3H), 2.78(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.62(s, 3H), 5.22(s, 2H), 7.20(d, J=8.4Hz, 1H), 
               
               
                   
                 7.37–7.44(m, 10H), 7.68(d, J=8.8Hz, 2H) 
               
               
                   
                 IR(KBr) 3433, 3032, 2939, 1519, 1473, 1366, 1178, 1151, 1004, 966, 870, 847, 795, 524cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 203 
               
               
                   
               
             
            
               
                 I-1026 
                 mp 158–159° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.47(t, J=6.9Hz, 3H), 2.41(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.14(q, J=6.9Hz, 2H), 
               
               
                   
                 5.22(s, 2H), 6.83(s, 1H), 6.91(dd, J=2.1, 8.1Hz, 1H), 6.96–7.01(m, 2H), 7.28–7.48(m, 7H), 7.66–7.72(m, 2H) 
               
               
                   
                 IR(KBr) 1517, 1482, 1392, 1362, 1240, 1194, 1175, 1146, 1084, 963, 878, 797cm −1   
               
               
                 I-1027 
                 mp 106–107° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.27(s, 6H), 3.87(s, 3H), 5.20(s, 2H), 6.93–7.00(m, 2H), 7.01–7.17(m, 5H), 7.23–7.52(m, 7H) 
               
               
                   
                 IR(KBr) 1607, 1522, 1490, 1467, 1455, 1383, 1294, 1267, 1246, 1178, 1125, 1028, 1011, 836, 813, 744cm −1   
               
               
                 I-108 
                 mp 162–163° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.45(t, J=6.9Hz, 3H), 3.46(s, 3H), 3.74(s, 3H), 4.15(q, J=6.9Hz, 2H), 4.98(s, 1H), 5.19(s, 2H), 
               
               
                   
                 5.91(s, 1H), 6.45(s, 1H), 6.88–6.94(m, 2H), 6.95–7.03(m, 2H), 7.05(d, J=1.2Hz, 1H), 7.27–7.41(m, 3H), 7.45–7.56(m, 4H) 
               
               
                   
                 IR(KBr) 3424, 3343, 1611, 1521, 1488, 1462, 1454, 1400, 1379, 1358, 1317, 1290, 1278, 1262, 1240, 1225, 1201, 1185, 
               
               
                   
                 1127, 1110, 1068, 1026, 1007, 828, 731cm −1   
               
               
                 I-1029 
                 mp 73–74° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.27(s, 6H), 3.86(s, 3H), 4.63(d, J=7.2Hz, 2H), 5.56(m, 1H), 6.92–7.00(m, 
               
               
                   
                 2H), 7.00–7.16(m, 5H), 7.26–7.34(m, 2H) 
               
               
                   
                 IR(KBr) 1610, 1521, 1489, 1461, 1438, 1297, 1276, 1249, 1231, 1181, 1122, 1028, 985, 835cm −1   
               
               
                 I-1030 
                 mp 86–87° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.46(t, J=6.9Hz, 3H), 1.75(s, 3H), 1.79(d, J=0.9Hz, 3H), 2.54(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 
               
               
                   
                 3.78(s, 3H), 4.12(q, J=6.9Hz, 2H), 4.63(d, J=6.3Hz, 2H), 5.53(m, 1H), 6.84(s, 1H), 6.93–7.01(m, 3H), 7.35–7.41(m, 
               
               
                   
                 2H), 7.67–7.73(m, 2H) 
               
               
                   
                 IR(KBr) 1518, 1480, 1449, 1413, 1389, 1366, 1239, 1199, 1180, 1150, 1082, 970, 872, 798cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 204 
               
               
                   
               
             
            
               
                 I-1031 
                 mp 145–146° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.44(t, J=6.9Hz, 3H), 1.74(s, 3H), 1.77(d, J=0.9Hz, 3H), 3.47(s, 3H), 3.75(s, 3H), 4.13(q, J=6.9Hz, 
               
               
                   
                 2H), 4.63(d, J=6.6Hz, 2H), 5.10(s, 1H), 5.56(m, 1H), 5.91(s, 1H), 6.46(s, 1H), 6.89–6.94(m, 2H), 6.95–7.03(m, 3H), 
               
               
                   
                 7.50–7.56(m, 2H) 
               
               
                   
                 IR(KBr) 3404, 1611, 1520, 1487, 1464, 1442, 1391, 1358, 1293, 1264, 1237, 1224, 1192, 1112, 1071, 1030, 1002, 831cm −1   
               
               
                 I-1032 
                 mp 142–145° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.13(s, 3H), 3.21(s, 3H), 4.63(s, 2H), 4.65(s, 2H), 5.19(s, 2H), 7.15(d, J=8.4Hz, 1H), 7.33–7.52(m, 
               
               
                   
                 13H) 
               
               
                   
                 IR(KBr) 3519, 3422, 3380, 3032, 2933, 1611, 1519, 1487, 1364, 1171, 1148, 1109, 969, 871, 817, 527cm −1   
               
               
                 I-1033 
                 mp 103–106° C. 
               
               
                   
                   1 H NMR(CDCl 3  + CD3OD) δ 1.78(s, 3H), 1.82(s, 3H), 3.22(s, 3H), 3.24(s, 3H), 4.58–4.67(m, 6H), 5.46–5.54(m, 1H), 7.09 
               
               
                   
                 (d, J=8.4Hz, 1H), 7.33–7.53(m, 8H) 
               
               
                   
                 IR(KBr) 3512, 3414, 3012, 2941, 1612, 1519, 1488, 1362, 1335, 1146, 997, 972, 876, 524cm −1   
               
               
                 I-1034 
                 mp 184–187° C. 
               
               
                   
                   1 H NMR(CDCl 3  + CD3OD) δ 1.78(s, 3H), 1.82(s, 3H), 4.59–4.65(m, 6H), 5.52–5.59(m, 1H), 6.84–6.98(m, 5H), 7.23–7.28 
               
               
                   
                 (m, 2H), 7.44(s, 1H), 7.45(s, 1H) 
               
               
                   
                 IR(KBr) 3400, 2931, 1611, 1521, 1491, 1247, 1203, 1009, 987, 834cm −1   
               
               
                 I-1035 
                 mp 95–96° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.27(s, 6H), 2.41(s, 3H), 5.19(s, 2H), 7.02–7.18(m, 5H), 7.22–7.54(m, 9H) 
               
               
                   
                 IR(KBr) 1522, 1512, 1454, 1377, 1309, 1297, 1274, 1267, 1236, 1125, 1008, 877, 822, 742, 696cm −1   
               
               
                 I-1036 
                 mp 95–96° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.24(s, 3H), 2.27(s, 3H), 5.19(s, 2H), 6.99–7.15(m, 5H), 7.26–7.52(m, 9H) 
               
               
                   
                 IR(KBr) 1518, 1499, 1482, 1454, 1380, 1300, 1278, 1262, 1227, 1125, 1090, 1021, 1015, 875, 834, 817, 739cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 205 
               
               
                   
               
             
            
               
                 I-1037 
                 mp 58–59° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(d, J=0.6Hz, 3H), 1.81(d, J=0.9Hz, 3H), 2.27(s, 6H), 2.41(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.56 
               
               
                   
                 (m, 1H), 6.98–7.14(m, 5H), 7.21–7.29(m, 4H) 
               
               
                   
                 IR(KBr) 1520, 1490, 1460, 1444, 1385, 1294, 1271, 1262, 1232, 1125, 1001, 828, 818cm −1   
               
               
                 I-1038 
                 mp 67–68° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(d, J=0.9Hz, 3H), 2.25(s, 3H), 2.27(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.55(m, 1H), 
               
               
                   
                 6.90–7.14(m, 5H), 7.26–7.32(m, 2H), 7.36–7.42(m, 2H) 
               
               
                   
                 IR(KBr) 1518, 1500, 1482, 1466, 1309, 1299, 1267, 1229, 1124, 1090, 995, 834cm −1   
               
               
                 I-1039 
                 mp 153–155° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 4.84(d, J=4.2Hz, 2H), 6.43–6.51(m, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 
               
               
                   
                 2H), 6.94–7.00(m, 2H), 7.08(brs, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3411, 1612, 1588, 1523, 1489, 1288, 1245, 1224, 1113, 1070, 1011, 938, 824cm −1   
               
               
                 I-1040 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.28(d, J=2.4Hz, 1H), 3.45(s, 3H), 3.75(s, 3H), 4.94(dd, J=6.0, 1.8Hz, 2H), 5.74(ddt, J=11.1, 2.4, 
               
               
                   
                 1.8Hz, 1H), 6.27(dt, J=11.1, 6.0Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.94–7.00(m, 2H), 7.07(d, J=2.1Hz, 1H), 
               
               
                   
                 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3433, 3279, 1612, 1588, 1523, 1489, 1286, 1248, 1223, 1113, 1070, 1011, 938, 825cm −1   
               
               
                 I-1041 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 4.90(d, J=1.8Hz, 2H), 5.55(dd, J=10.8, 2.4Hz, 1H), 5.71(dd, J=17.7, 2.4Hz, 
               
               
                   
                 1H), 5.85(ddt, J=17.7, 10.8, 1.8Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.97(dd, J=8.4, 2.1Hz, 1H), 7.07(d, J=8.4Hz, 
               
               
                   
                 1H), 7.08(d, J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3433, 1612, 1589, 1523, 1489, 1286, 1224, 1192, 1112, 1070, 1002, 937, 825, 815cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 206 
               
               
                   
               
             
            
               
                 I-1042 
                 mp 185–187° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.76(s, 3H), 3.23(s, 3H), 3.50(s, 3H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H), 
               
               
                   
                 5.50(t, J=6.6Hz, 1H), 6.63(t, J=2.4Hz, 1H), 6.95(s, 1H), 7.09(d, J=8.5Hz, 1H), 7.26–7.29(m, 1H), 7.37(dd, J=8.5, 2.1Hz, 
               
               
                   
                 1H), 7.42(d, J=2.1Hz, 1H), 7.45–7.51(m, 2H), 7.89(s, 1H), 8.26(br s, 1H) 
               
               
                   
                 IR(KBr) 3418, 1473, 1362, 1177, 1079, 961, 817, 796cm −1   
               
               
                 I-1043 
                 mp 152–154° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.43(s, 3H), 3.76(s, 3H), 4.61(d, J=6.9Hz, 2H), 5.53(t, J=6.9Hz, 1H), 
               
               
                   
                 5.69(s, 1H), 5.98(s, 1H), 6.55(s, 1H), 6.63(t, J=2.1Hz, 1H), 6.94–7.01(m, 2H), 7.10(d, J=0.9Hz, 1H), 7.25–7.27(m, 1H), 
               
               
                   
                 7.46(d, J=8.4Hz, 1H), 7.51(dd, J=8.5, 1.5Hz, 1H), 7.89(s, 1H), 8.24(br s, 1H) 
               
               
                   
                 IR(CHCl 3 ) 3529, 3480, 1515, 1495, 1407, 1291, 1246, 1107, 1070cm −1   
               
               
                 I-104 
                 mp 127–128° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.45(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 3.91(s, 3H), 5.22(s, 2H), 6.84(s, 1H), 6.91(dd, J=8.4, 2.1Hz, 
               
               
                   
                 1H), 6.79–7.00(m, 2H), 7.12–7.18(m, 2H), 7.30–7.47(m, 5H), 7.59–7.63(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 2938, 2843, 1606, 1585, 1520, 1483, 1464, 1443, 1390, 1368, 1174, 1141, 1083, 1013, 962, 936, 865, 838cm −1   
               
               
                 I-1045 
                 mp 124–127° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.46(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 3.91(s, 3H), 5.21(s, 2H), 5.42(br, 1H), 6.82(s, 1H), 6.90(dd, J=8.4, 
               
               
                   
                 1.8Hz, 1H), 6.97–7.10(m, 3H), 7.29–7.47(m, 7H) 
               
               
                   
                 IR(CHCl 3 ) 3579, 2938, 1600, 1523, 1484, 1464, 1393, 1368, 1327, 1282, 1174, 1141, 1081, 1036, 1012, 962, 908cm −1   
               
               
                 I-1046 
                 mp 178–180° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.44(s, 3H), 3.29(s, 3H), 3.58(s, 3H), 3.78(s, 3H), 3.91(s, 3H), 5.22(s, 2H), 6.83(s, 1H), 6.99(dd, J=8.1, 
               
               
                   
                 2.1Hz, 1H), 6.97–7.25(m, 2H), 7.31–7.58(m, 8H) 
               
               
                   
                 IR(CHCl 3 ) 2939, 2840, 1591, 1519, 1483, 1464, 1374, 1331, 1173, 1141, 1116, 1082, 1012, 964, 863cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 207 
               
               
                   
               
             
            
               
                 I-107 
                 mp 98–99° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.35(s, 3H), 5.22(s, 2H), 6.59(t, J F-H=54.6Hz, 2H), 7.09–7.50(m, 12H), 7.74–7.75(d, J=4.5Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(CHCl 3 ) 1752, 1523, 1493, 1384, 1273, 1169, 1133, 1070, 1037, 916, 851cm −1   
               
               
                 I-1048 
                 mp 112–114° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75–1.76(d, J=0.6Hz, 3H), 1.78–1.79(d, J=0.9Hz, 3H), 2.57(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 3.89 
               
               
                   
                 (s, 3H), 4.62–4.64(d, J=7.5Hz, 2H), 5.54(s, 1H), 6.84(s, 1H), 6.96–6.97(m, 3H), 7.12–7.18(m, 2H), 7.59–7.64(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 2938, 1606, 1583, 1519, 1483, 1464, 1443, 1416, 1389, 1368, 1175, 1141, 1083, 1038, 1013, 962, 936, 865, 838cm −1   
               
               
                 I-1049 
                 mp 203–204° C. 
               
               
                   
                   1 H NMR(CD3OD) δ 4.53(s, 2H), 4.55(s, 2H), 5.21(s, 2H), 6.84–6.88(m, 2H), 7.12–7.50(m, 12H) 
               
               
                   
                 IR(KBr) 3380, 1611, 1586, 1523, 1490, 1462, 1434, 1380, 1317, 1300, 1258, 1194, 1173, 1128, 1033, 1007, 906, 871, 836, 
               
               
                   
                 817, 787, 730, 693, 646cm −1   
               
               
                 I-1050 
                 mp 99–100° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.78–1.79(d, J=0.9Hz, 3H), 3.46(s, 3H), 3.75(s, 3H), 3.88(s, 3H), 4.62–4.64(d, J=6.6Hz, 
               
               
                   
                 2H), 5.57(m, 1H), 5.89(s, 1H), 6.46(s, 1H), 6.96–7.02(m, 3H), 7.12–7.18(m, 2H), 7.59–7.64(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3513, 2938, 1605, 1583, 1490, 1423, 1407, 1392, 1362, 1318, 1269, 1177, 1158, 1140, 1118, 1078, 1038, 1012, 
               
               
                   
                 930, 846, 826cm −1   
               
               
                 I-1051 
                 mp 153–154° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.79–1.80(d, J=0.9Hz, 3H), 2.57(s, 3H), 3.29(s, 3H), 3.60(s, 3H), 3.79(s, 3H), 3.89(s, 
               
               
                   
                 3H), 4.62–4.64(d, J=6.6Hz, 2H), 5.54(m, 1H), 6.84(s, 1H), 6.96–6.97(m, 4H), 7.46–7.59(m, 3H) 
               
               
                   
                 IR(CHCl 3 ) 2938, 1592, 1519, 1483, 1464,. 1374, 1332, 1239, 1173, 1141, 1116, 1082, 1038, 1011, 965, 864cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 208 
               
               
                   
               
             
            
               
                 I-1052 
                 amorphous 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.12(s, 3H), 3.47(s, 3H), 5.15(s, 2H), 5.82–6.08(m, 3H), 6.70–6.95(m, 5H), 7.02(d, J=8.1Hz, 1H), 
               
               
                   
                 7.39–7.52(m, 7H) 
               
               
                   
                 IR(CHCl 3 ) 3597, 3535, 2937, 1731, 1612, 1589, 1522, 1489, 1455, 1401, 1382, 1328, 1309, 1288, 1173, 1128, 1096, 1011, 
               
               
                   
                 939, 835cm −1   
               
               
                 I-1053 
                 mp 141–142° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.78–1.79(d, J=0.9Hz, 3H), 3.49(s, 3H), 3.76(s, 3H), 3.89(s, 3H), 4.62–4.64(d, J=6.6Hz, 
               
               
                   
                 2H), 5.30(d, J F-H=3.3Hz, 1H), 5.57(m, 1H), 5.88(s, 1H), 6.45(s, 1H), 6.99–7.11(m, 4H), 7.33(m, 1H), 7.43(dd, J=11.7, 
               
               
                   
                 2.1Hz, 1H) 
               
               
                   
                 IR(CHCl 3 ) 3578, 3514, 1621, 1600, 1583, 1523, 1492, 1464, 1397, 1320, 1279, 1175, 1140, 1116, 1100, 1076, 1038, 1011, 
               
               
                   
                 902cm −1   
               
               
                 I-1054 
                 mp 138–140° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 5.17(s, 2H), 5.60(s, 1H), 5.72(s, 1H), 6.98–7.02(m, 2H), 7.10–7.14(m, 3H), 7.18(s, 1H), 7.35(s, 1H), 
               
               
                   
                 7.37–7.47(m, 5H), 7.59–7.61(m, 2H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1590, 1528, 1503, 1483, 1454, 1386, 1294, 1254, 1223, 1187, 1132, 1086, 1009cm −1   
               
               
                 I-1055 
                 mp 176–178° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.13(s, 3H), 3.32(s, 3H), 5.19(s, 2H), 7.16(d, J=8.7Hz, 1H), 7.37–7.55(m, 9H), 7.61–7.64(m, 4H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1611, 1525, 1503, 1469, 1359, 1290, 1244, 1170, 1088, 979cm −1   
               
               
                 I-1056 
                 mp 134–136° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 3.23(s, 3H), 3.32(s, 3H), 4.64(d, J=6.9Hz, 1H), 5.48–5.54(m, 1H), 7.10(d, 
               
               
                   
                 J=8.4Hz, 1H), 7.44–7.55(m, 4H), 7.58–7.65(m, 4H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1609, 1527, 1504, 1469, 1351, 1289, 1277, 1186, 1171, 1115, 1089, 973cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 209 
               
               
                   
               
             
            
               
                 I-1057 
                 mp 97–100° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(d, J=0.9Hz, 3H), 1.82(d, J=0.9Hz, 3H), 4.63(d, J=7.2Hz, 2H), 5.50–5.54(m, 1H), 5.62(br s, 
               
               
                   
                 1H), 5.74(br s, 1H), 6.95(d, J=8.7Hz, 1H), 7.12(dd, J=2.4, 8.7Hz, 1H), 7.18(s 1H), 7.24(d, J=2.4Hz, 1H), 7.36(s, 1H), 
               
               
                   
                 7.42–7.46(m, 2H), 7.58–7.62(m, 2H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1599, 1588, 1528, 1482, 1385, 1326, 1289, 1252, 1212, 1193, 1132, 1112, 1084, 1056, 1001cm −1   
               
               
                 I-1058 
                 mp 216–218° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.93(s, 12H), 3.73(s, 6H), 6.74–6.79(m, 4H), 6.92(s, 2H), 7.38–7.43(m, 4H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1616, 1533, 1496, 1458, 1442, 1387, 1360, 1230, 1202, 1169, 1059, 1035cm −1   
               
               
                 I-1059 
                 mp 122–123° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.74(d, J=0.6Hz, 3H), 1.78(d, J=0.6Hz, 3H), 2.26(s, 3H), 2.29(s, 3H), 3.77(d, J=6.9Hz, 2H), 
               
               
                   
                 4.83(br, 1H), 5.36–5.41(m, 1H), 6.61–6.77(m, 1H), 6.86–6.91(m, 2H), 6.99–7.04(m, 2H), 7.10(s, 1H), 7.11(s, 1H), 7.21–7.26 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1626, 1608, 1526, 1489, 1428, 1336, 1300, 1252, 1209, 1187cm −1   
               
               
                 I-1060 
                 mp foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.74(s, 3H), 1.77(s, 3H), 2.27(s, 3H), 2.31(s, 3H), 3.76(d, J=6.6Hz, 2H), 3.86(s, 3H), 5.38–5.43(m, 
               
               
                   
                 1H), 6.66(d, J=8.1Hz, 1H), 6.80(d, J=1.8Hz, 1H), 6.86–6.90(m, 3H), 7.11(s, 1H), 7.16(s, 1H), 7.23–7.26(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3600–2800(br), 1730, 1611, 1525, 1489, 1455, 1256, 1171, 1137, 1100, 1036cm −1   
               
               
                 I-1061 
                 mp 191–193° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.01(s, 6H), 3.79(s, 3H), 3.80(s, 3H), 6.79–6.83(m, 2H), 6.92(s, 1H), 6.98(s, 1H), 7.41–7.51(m, 4H), 
               
               
                   
                 8.12(br s, 1H), 8.26–8.32(m, 1H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1712, 1617, 1600, 1536, 1494, 1460, 1446, 1385, 1364, 1290, 1212, 1162, 1057, 1035cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 210 
               
               
                   
               
             
            
               
                 I-1062 
                 mp 240–245° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.82(s, 6H), 6.95(s, 2H), 7.41–7.49(m, 4H), 8.13(br s, 2H), 8.29–8.35(m, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1725, 1598, 1544, 1492, 1381, 1294, 1215, 1197, 1165, 1109, 1055, 1033cm −1   
               
               
                 I-1063 
                   1 H NMR(CDCl 3 ) δ 1.99(s, 6H), 2.17(s, 3H), 3.21(s, 3H), 5.20(s, 2H), 6.95–7.11(m, 4H), 7.23(d, J=8.7Hz, 2H), 7.33–7.52 
               
               
                   
                 (m, 7H) 
               
               
                   
                 IR(KBr)1617, 1577, 1513, 1366, 1295, 1267, 1198, 1173, 1149, 1127, 1106cm −1   
               
               
                 I-1064 
                   1 H NMR(CDCl 3 ) δ 1.99(s, 6H), 2.17(s, 3H), 3.21(s, 3H), 5.18(d, J=3.9Hz, 1H), 6.97–7.10(m, 4H), 7.23(d, J=8.7Hz, 
               
               
                   
                 2H), 7.37(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3442, 1620, 1597, 1519, 1472, 1356, 1279, 1232, 1174, 1147, 1103cm −1   
               
               
                 I-1065 
                   1 H NMR(CDCl 3 ) δ 1.78(s, 3H), 1.83(s, 3H), 2.00(s, 6H), 2.19(s, 3H), 3.22(s, 3H), 4.65(d, J=6.3Hz, 2H), 5.52–5.62(m, 
               
               
                   
                 1H), 6.96–7.13(m, 4H), 7.24(d, J=8.7Hz, 2H), 7.38(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)1617, 1576, 1514, 1466, 1359, 1297, 1268, 1204, 1151, 1002cm −1   
               
               
                 I-1066 
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.01(s, 6H), 2.18(s, 3H), 4.63(d, J=6.9Hz, 2H), 4.75(s, 1H), 5.52–5.60(m, 
               
               
                   
                 1H), 6.82–7.11(m, 8H) 
               
               
                   
                 IR(KBr)3433, 1606, 1517, 1466, 1297, 1269, 1221, 1128, 1107, 1004cm −1   
               
               
                 I-1067 
                   1 H NMR(CDCl 3 ) δ: 2.25(s, 3H), 2.27(s, 3H), 2.31(s, 3H), 3.20(s, 3H), 4.75(s, 1H), 6.83(d, J=8.4Hz, 1H), 7.05–7.14 
               
               
                   
                 (m, 4H), 7.34(d, J=8.4Hz, 2H), 7.42(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3494, 3435, 1604, 1517, 1488, 1375, 1327, 1199, 1171, 1148, 1118cm −1   
               
               
                 I-1068 
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.25(s, 3H), 2.28(s, 6H), 3.20(s, 3H), 4.58(d, J=6.6Hz, 2H), 5.50–5.58 
               
               
                   
                 (m, 1H), 6.88(d, J=9.0Hz, 1H), 7.08–7.16(m, 4H), 7.34(.d, J=8.7Hz, 2H), 742(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)1604, 1513, 1486, 1367, 1238, 1176, 1153, 1131, 1002cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 211 
               
               
                   
               
             
            
               
                 I-1069 
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.26(s, 3H), 2.28(s, 6H), 4.57(d, J=6.6Hz, 2H), 4.80(s, 1H), 5.50–5.58 
               
               
                   
                 (m, 1H), 6.85–6.91(m, 3H), 7.09–7.17(m, 3H), 7.21–7.28(m, 3H) 
               
               
                   
                 IR(KBr)3436, 1608, 1518, 1488, 1238, 1130, 1008cm −1   
               
               
                 I-1070 
                   1 H NMR(CDCl 3 ) δ: 2.26(s, 3H), 2.30(s, 3H), 3.00(s, 6H), 5.19(s, 2H), 6.80(.d, J=8.7Hz, 2H), 7.02–7.16(m, 5H), 7.26 
               
               
                   
                 (d, J=8.7Hz, 2H), 7.33–7.51(m, 5H) 
               
               
                   
                 IR(KBr)1608, 1527, 1490, 1355, 1297, 1270, 1262, 1231, 1121, 1022cm −1   
               
               
                 I-1071 
                   1 H NMR(CDCl 3 ) δ 2.26(s, 3H), 2.30(s, 3H), 3.01(s, 6H), 5.09(s, 1H), 6.80(d, J=8.4Hz, 2H), 7.01–7.15(m, 5H), 7.27(.d, 
               
               
                   
                 J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3432, 1613, 1590, 1526, 1489, 1307, 1283, 1241, 1138, 1111cm −1   
               
               
                 I-1072 
                   1 H NMR(CDCl 3 ) δ: 1.77(s, 3H), 1.81(s, 3H), 2.27(s, 3H), 2.30(s, 3H), 3.00(s, 6H), 4.63(d, J=6.6Hz, 2H), 5.51–5.59(m, 
               
               
                   
                 1H), 6.80(d, J=8.4Hz, 2H), 6.97–7.16(m, 5H), 7.27(d, J=8.14Hz, 2H) 
               
               
                   
                 IR(KBr)1611, 1528, 1489, 1353, 1297, 1266, 1228, 1122, 1011cm −1   
               
               
                 I-1073 
                 mp 182–184° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.48(s, 3H), 1.67(s, 3H), 1.91(s, 3H), 3.46(s, 3H), 3.76(s, 3H), 3.84(s, 3H), 3.94–4.03(m, 1H), 4.05–4.59 
               
               
                   
                 (m, 1H), 5.23–5.32(m, 1H), 5.74(br s, 1H), 6.05(s, 1H), 6.48(s, 1H), 6.93–6.99(m, 2H), 7.04–7.10(m, 3H), 7.51–7.56(m, 
               
               
                   
                 3H) 
               
               
                   
                 IR(KBr)3400, 2934, 1625, 1523, 1396, 1227, 1119, 1077, 1036, 826, 589cm −1   
               
               
                 I-1074 
                 mp 153–154° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.74(s, 3H), 1.78(s, 3H), 2.30(s, 3H), 2.31(s, 3H), 3.75(d, J=6.6Hz, 2H), 3.86(s, 3H), 3.87(s, 3H), 
               
               
                   
                 5.37–5.45(m, 1H), 6.66(d, J=8.4Hz, 1H), 6.74–6.83(m, 5H), 6.89(dd, J=1.8, 8.1Hz, 1H), 7.14(s, 1H), 7.16(s, 1H) 
               
               
                   
                 IR(KBr)3408, 3389, 3294, 3210, 2919, 2835, 1528, 1495, 1275, 1208, 1032, 856, 826cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 212 
               
               
                   
               
             
            
               
                 I-1075 
                 mp 168–171° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.74(s, 6H), 1.77(s, 6H), 2.31(s, 6H), 3.75(d, J=6.9Hz, 4H), 3.86(s, 6H), 5.37–5.45(m, 2H), 6.66(d, 
               
               
                   
                 J=8.1Hz, 2H), 6.80(d, J=1.8Hz, 2H), 6.89(dd, J=1.8, 8.1Hz, 2H), 7.16(s, 1H) 
               
               
                   
                 IR(KBr)3423, 2968, 2927, 2912, 2849, 1609, 1526, 1498, 1454, 1261, 1209, 1135, 1030, 855, 803cm −1   
               
               
                 I-1076 
                 mp 79–80° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.54(s, 3H), 3.19(s, 3H), 3.85(s, 3H), 5.17(s, 2H), 5.71(brs, 1H), 6.93(d, J=8.1Hz, 1H), 7.01–7.07 
               
               
                   
                 (m, 3H), 7.24–7.26(m, 2H), 7.37–7.43(m, 7H), 7.66(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3466, 3029, 2939, 2937, 1610, 1520, 1482, 1365, 1246, 1201, 1175, 1150, 1073, 969, 872, 839, 804cm −1   
               
               
                 I-1077 
                 mp 151–152° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 4.00(s, 3H), 4.91(brs, 1H), 5.24(s, 2H), 6.89(d, J=8.2Hz, 2H), 7.00(d, J=8.0Hz, 1H), 7.12–7.47(m, 
               
               
                   
                 10H), 7.71(d, J=7.4Hz, 1H), 7.89(s, 1H) 
               
               
                   
                 IR(KBr)3422, 1612, 1526, 1491, 1454, 1329, 1287, 1269, 1248, 1171, 1136, 1103, 1019, 827cm −1   
               
               
                 I-1078 
                 mp 173–174° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.13(s, 3H), 4.92(brs, 1H), 5.19(s, 2H), 6.88(d, J=8.6Hz, 2H), 7.15–7.26(m, 4H), 7.35–7.59(m, 7H), 
               
               
                   
                 7.69(d, J=9.4Hz, 1H), 7.86(s, 1H) 
               
               
                   
                 IR(KBr)3426, 1613, 1527, 1489, 1435, 1361, 1330, 1294, 1243, 1164, 1118, 1070, 978, 821cm −1   
               
               
                 I-1079 
                 mp 168–169° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.20(s, 3H), 3.99(s, 3H), 5.22(s, 2H), 6.89(d, J=8.8Hz, 1H), 7.11–7.15(m, 2H), 7.31–7.49(m, 10H), 
               
               
                   
                 7.73(d, J=7.4Hz, 1H), 7.90(s, 1H) 
               
               
                   
                 IR(KBr)3434, 1603, 1524, 1488, 1369, 1335, 1244, 1178, 1143, 1119, 1006, 871cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 213 
               
               
                   
               
             
            
               
                 I-1080 
                 mp 68–69° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.13(s, 3H), 3.19(s, 3H), 5.19(s, 2H), 7.18(d, J=8.6Hz, 2H), 7.26–7.59(m, 11H), 7.73(d, J=9.2Hz, 
               
               
                   
                 1H), 7.89(s, 1H) 
               
               
                   
                 IR(KBr)3431, 3034, 2938, 1613, 1524, 1487, 1367, 1330, 1293, 1242, 1175, 1151, 1118, 970, 872, 828cm −1   
               
               
                 I-1081 
                 mp 74–76° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.78(s, 3H), 1.84(s, 3H), 3.51(s, 3H), 4.64(d, J=5.6Hz, 2H), 5.08(brs, 2H), 5.49–5.54(m, 1H), 5.75 
               
               
                   
                 (brs, 1H), 5.85(brs, 1H), 6.14(s, 1H), 6.89–7.12(m, 5H), 7.53(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3444, 2934, 1612, 1523, 1485, 1403, 1360, 1251, 1172, 1006, 971, 837, 527cm −1   
               
               
                 I-1082 
                 mp 71–72° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.46(s, 3H), 3.20(s, 3H), 3.86(s, 3H), 3.91(s, 3H), 5.21(s, 2H), 6.87–7.03(m, 3H), 7.11(s, 1H), 7.24–7.41 
               
               
                   
                 (m, 8H), 7.67(d, J=8.8Hz, 2H) 
               
               
                   
                 IR(KBr)3434, 3028, 2936, 1609, 1521, 1482, 1365, 1239, 1176, 1074, 969, 869, 804cm −1   
               
               
                 I-1083 
                 mp 73–74° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.66(s, 3H), 3.13(s, 3H), 3.20(s, 3H), 3.86(s, 3H), 5.19(s, 2H), 7.08(d, J=1.6Hz, 1H), 7.16(d, J=8.4Hz, 
               
               
                   
                 1H), 7.21–7.28(m, 2H), 7.37–7.42(m, 8H), 7.66(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3432, 3031, 2938, 1610, 1523, 1480, 1365, 1176, 1151, 1074, 970, 875, 807, 524cm −1   
               
               
                 I-1084 
                 mp 110–111° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.78(s, 3H), 1.81(s, 3H), 3.21(s, 3H), 3.98(s, 3H), 4.67(d, J=6.6Hz, 2H), 5.57(t, J=6.8Hz, 1H), 
               
               
                   
                 7.01(d, J=8.0Hz, 1H), 7.15–7.21(m, 2H), 7.28–7.45(m, 4H), 7.76(d, J=7.6Hz, 1H), 7.93(s, 1H), 8.03(s, 1H) 
               
               
                   
                 IR(KBr)3434, 3010, 2931, 1524, 1488, 1368, 1336, 1247, 1173, 1149, 1121, 1007, 871, 562cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 214 
               
               
                   
               
             
            
               
                 I-1085 
                 mp 147–148° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.79(s, 3H), 3.96(s, 3H), 4.65(d, J=6.3Hz, 2H), 4.91(brs, 1H), 5.55(t, J=5.7Hz, 1H), 
               
               
                   
                 6.88(d, J=8.1Hz, 2H), 6.99(d, J=8.4Hz, 1H), 7.12–7.26(m, 4H), 7.36(d, J=8.1Hz, 1H), 7.89(s, 1H) 
               
               
                   
                 IR(KBr)3450, 2938, 1612, 1524, 1490, 1436, 1340, 1264, 1230, 1212, 1139, 1123, 984, 835cm −1   
               
               
                 I-1086 
                 mp 134–135° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 4.64(d, J=6.6Hz, 2H), 4.84(brs, 1H), 5.52(t, J=7.2Hz, 1H), 5.77(s, 1H), 
               
               
                   
                 6.87(d, J=8.7Hz, 2H), 6.96(d, J=8.4Hz, 1H), 7.12(dd, J=2.4, 8.7Hz, 1H), 7.35(d, J=8.1Hz, 1H), 7.70(d, J=8.4Hz, 
               
               
                   
                 1H), 7.89(s, 1H) 
               
               
                   
                 IR(KBr)3367, 1610, 1489, 1442, 1333, 1265, 1193, 1165, 1124, 834, 805cm −1   
               
               
                 I-1087 
                 mp 156–157° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.78(s, 3H), 1.81(s, 3H), 3.82(s, 3H), 3.89(s, 3H), 4.65(d, J=6.2Hz, 2H), 4.95(brs, 1H), 5.22(brs, 
               
               
                   
                 1H), 5.58(t, J=6.0Hz, 1H), 6.73(s, 1H), 6.87–7.00(m, 6H), 7.53(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr)3394, 2934, 1610, 1526, 1499, 1455, 1402, 1240, 1221, 1139, 1099, 894, 815cm −1   
               
               
                 I-1088 
                 mp 69–70° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.83(s, 3H), 3.80(s, 3H), 4.63(d, J=7.0Hz, 2H), 4.93(brs, 1H), 5.22(brs, 1H), 5.52(t, J=7.0Hz, 
               
               
                   
                 1H), 5.78(brs, 1H), 6.70(d, J=1.6Hz, 1H), 6.83–7.01(m, 6H), 7.51(d, J=8.8Hz, 2H) 
               
               
                   
                 IR(KBr)3411, 2933, 1611, 1526, 1492, 1453, 1263, 1242, 1220, 1190, 1172, 1096, 907, 822cm −1   
               
               
                 I-1089 
                 mp 160–161° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.39(d, J=6.0Hz, 6H), 2.40(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.55(m, 1H), 5.20(s, 2H), 
               
               
                   
                 6.83(s, 1H), 6.93(dd, J=1.8, 8.1Hz, 1H), 7.01(d, J=8.1Hz, 1H), 7.01(d, J=1.8Hz, 1H), 7.28–7.48(m, 7H), 7.66–7.72(m, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr)1515, 1480, 1463, 1391, 1363, 1239, 1192, 1176, 1149, 1082, 1018, 962, 873, 800cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 215 
               
               
                   
               
             
            
               
                 I-1090 
                 mp 154–155° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.59(s, 3H), 3.21(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 5.23(s, 2H), 6.84(s, 1H), 7.06(d, J=8.4Hz, 1H), 
               
               
                   
                 7.24–7.50(m, 9H), 7.65–7.71(m, 2H) 
               
               
                   
                 IR(KBr)1513, 1479, 1365, 1267, 1232, 1178, 1150, 1079, 971, 959, 875, 797cm −1   
               
               
                 I-1091 
                 mp 137–138° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.38(d, J=6.3Hz, 6H), 3.46(s, 3H), 3.74(s, 3H), 4.54(m, 1H), 4.96(s, 1H), 5.17(s, 2H), 5.92(s, 1H), 
               
               
                   
                 6.45(s, 1H), 6.89–6.94(m, 2H), 7.00–7.11(m, 3H), 7.27–7.41(m, 3H), 7.45–7.56(m, 4H) 
               
               
                   
                 IR(KBr)3443, 3356, 1611, 1521, 1488, 1458, 1393, 1269, 1236, 1138, 1112, 1074, 1013, 830, 743cm −1   
               
               
                 I-1092 
                 mp 75–76° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.37(d, J=5.8Hz, 6H), 1.75(s, 3H), 1.79(s, 3H), 2.53(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 
               
               
                   
                 4.51(m, 1H), 4.61(d, J=6.6Hz, 2H), 5.52(m, 1H), 6.84(s, 1H), 6.96–7.02(m, 3H), 7.34–7.42(m, 2H), 7.65–7.74(m, 2H) 
               
               
                   
                 IR(KBr)1516, 1480, 1449, 1360, 1332, 1240, 1199, 1177, 1152, 1083, 964, 873, 797cm −1   
               
               
                 I-1093 
                 mp 119–120° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.37(d, J=6.3Hz, 6H), 1.73(s, 3H), 1.77(d, J=0.9Hz, 3H), 3.46(s, 3H), 3.75(s, 3H), 4.51(m, 1H), 
               
               
                   
                 4.61(d, J=6.6Hz, 2H), 5.14(s, 1H), 5.54(m, 1H), 5.93(s, 1H), 6.46(s, 1H), 6.89–6.95(m, 2H), 6.98(d, J=8.1Hz, 1H), 
               
               
                   
                 7.01–7.07(m, 2H), 7.50–7.56(m, 2H) 
               
               
                   
                 IR(KBr)3426, 1610, 1522, 1488, 1455, 1402, 1267, 1237, 1174, 1135, 1112, 1079, 1020cm −1   
               
               
                 I-1094 
                 mp 150–151° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.44(s, 3H), 3.75(s, 3H), 4.90(s, 1H), 5.20(s, 2H), 5.99(s, 1H), 6.44(s, 1H), 6.88–6.95(m, 2H), 7.04(d, 
               
               
                   
                 J=8.4Hz, 1H), 7.29–7.44(m, 4H), 7.47–7.56(m, 5H) 
               
               
                   
                 IR(KBr)3410, 1610, 1519, 1484, 1463, 1455, 1410, 1382, 1359, 1285, 1264, 1229, 1118, 1074, 1060, 1014, 995cm −1   
               
               
                 I-1095 
                   1 H NMR(CDCl 3 ) δ 0.96(s, 3H), 0.98(s, 3H), 1.53–1.82(m, 3H), 2.99(s, 6H), 3.20(t, J=7.2Hz, 2H), 3.78(s, 3H), 3.79(s, 
               
               
                   
                 3H), 3.87(br, 1H), 6.71–6.83(m, 3H), 6.92(s, 1H), 6.94(s, 1H), 7.23–7.31(m, 2H), 7.47–7.52(m, 2H) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 216 
               
               
                   
               
             
            
               
                 I-1096 
                 mp 87–89° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.70(s, 3H), 1.75(s, 3H), 2.82(s, 3H), 3.00(s, 3H), 3.74–3.80(m, 2H), 3.78(s, 3H), 3.80(s, 3H), 5.29–5.34 
               
               
                   
                 (m, 1H), 6.79–6.83(m, 2H), 6.92–6.97(m, 3H), 7.25–7.34(m, 2H), 7.47–7.52(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1613, 1531, 1495, 1460, 1448, 1380, 1359, 1253, 1210, 1057, 1036cm −1   
               
               
                 I-1097 
                 mp 167–169° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.92(s, 3H), 3.00(s, 6H), 3.78(s, 3H), 3.79(s, 3H), 4.02(br, 1H), 6.71–6.83(m, 3H), 6.92(s, 1H), 6.95 
               
               
                   
                 (s, 1H), 7.25–7.32(m, 2H), 7.47–7.52(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1625, 1613, 1533, 1497, 1462, 1445, 1381, 1358, 1328, 1262, 1205, 1163, 1051, 1031cm −1   
               
               
                 I-1098 
                 mp 114–115° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.27(s, 6H), 2.54(s, 3H), 5.19(s, 2H), 7.00–7.16(m, 5H), 7.26–7.51(m, 9H) 
               
               
                   
                 IR(KBr)1519, 1501, 1483, 1454, 1310, 1295, 1263, 1232, 1123, 998, 744cm −1   
               
               
                 I-1099 
                 mp 68–69° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.62(br s, 1H), 1.77(s, 3H), 1.82(s, 3H), 2.27(s, 3H), 2.28(s, 3H), 4.64(d, J=6.8Hz, 2H), 4.76(s, 
               
               
                   
                 2H), 5.56(m, 1H), 7.00–7.16(m, 5H), 7.33–7.48(m, 4H) 
               
               
                   
                 IR(KBr)3433, 1522, 1490, 1384, 1311, 1296, 1266, 1232, 1194, 1122, 1025, 1013, 992, 841, 818cm −1   
               
               
                 I-1100 
                 mp 68–69° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.62(br s, 1H), 1.77(s, 3H), 1.82(s, 3H), 2.27(s, 3H), 2.28(s, 3H), 4.64(d, J=6.8Hz, 2H), 4.76(s, 
               
               
                   
                 2H), 5.56(m, 1H), 7.00–7.16(m, 5H), 7.33–7.48(m, 4H) 
               
               
                   
                 IR(KBr)3433, 1522, 1490, 1384, 1311, 1296, 1266, 1232, 1194, 1122, 1025, 1013, 992, 841, 818cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 217 
               
               
                   
               
             
            
               
                 I-1101 
                 mp 171° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(d, J=0.9Hz, 3H), 2.68(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 4.65(d, J=6.6Hz, 
               
               
                   
                 2H), 5.53(m, 1H), 6.84(s, 1H), 7.03(d, J=8.7Hz, 1H), 7.29(dd, J=2.1, 8.7Hz, 1H), 7.36–7.41(m, 2H), 7.46(d, J=2.1Hz, 
               
               
                   
                 1H), 7.66–7.72(m, 2H) 
               
               
                   
                 IR(KBr)1510, 1477, 1376, 1358, 1349, 1294, 1237, 1196, 1173, 1145, 1077, 1004, 958, 861, 801cm −1   
               
               
                 I-1102 
                 mp 168–169° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(d, J=0.3Hz, 3H), 1.80(d, J=0.9Hz, 3H), 3.44(s, 3H), 3.75(s, 3H), 4.64(d, J=6.6Hz, 2H), 4.97 
               
               
                   
                 (s, 1H), 5.55(m, 1H), 6.00(s, 1H), 6.45(s, 1H), 6.89–6.95(m, 2H), 7.01(d, J=8.4Hz, 1H), 7.33(dd, J=2.1, 8.4Hz, 1H), 7.51 
               
               
                   
                 (d, J=2.1Hz, 1H), 7.51–7.56(m, 2H) 
               
               
                   
                 IR(KBr)3396, 1613, 1521, 1485, 1467, 1440, 1408, 1384, 1357, 1286, 1264, 1229, 1116, 1076, 1056, 993, 834cm −1   
               
               
                 I-1103 
                 mp 176–177° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.80(s, 3H), 2.09(s, 3H), 2.16(s, 3H), 3.87(s, 3H), 4.65(d, J=7.2Hz, 2H), 4.78(br s, 1H), 
               
               
                   
                 5.06(s, 1H), 5.40–5.60(m, 1H), 6.76(s, 1H), 6.82–6.91(m, 4H), 7.02(d, J=7.8Hz, 1H), 7.22–7.27(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3597, 3533, 3026, 3010, 2921, 1731, 1612, 1520, 1488, 1240, 1172cm −1   
               
               
                 I-1104 
                 mp 185–186° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.78(s, 3H), 1.82(s, 3H), 2.06(s, 3H), 2.15(s, 3H), 4.66(d, J=6.9Hz, 2H), 4.71(s, 1H), 4.89(s, 1H), 
               
               
                   
                 5.53–5.58(m, 1H), 6.75(s, 1H), 6.86–6.91(m, 2H), 6.90–7.00(m, 3H), 7.21–7.26(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3691, 3598, 3546, 3068, 2922, 1674, 1613, 1520, 1488, 1298, 1262, 1165cm −1   
               
               
                 I-1105 
                 mp 143–144° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.48(s, 3H), 3.21(s, 3H), 3.52(s, 3H), 3.67(d, J=1.2Hz, 3H), 3.92(s, 3H), 5.23(s, 2H), 6.92–7.02(m, 
               
               
                   
                 3H), 7.31–7.48(m, 7H), 7.60(dd, J=8.7, 1.5Hz, 2H) 
               
               
                   
                 IR(KBr)1519, 1470, 1370, 1256, 1173, 1152, 1029, 872cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 218 
               
               
                   
               
             
            
               
                 I-1106 
                 mp 128–130° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(s, 3H), 2.59(s, 3H), 3.21(s, 3H), 3.53(s, 3H), 3.67(d, J=0.9Hz, 3H), 3.90(s, 3H), 
               
               
                   
                 4.64(d, J=6.9Hz, 2H), 5.55(t, J=6.9Hz, 1H), 6.97–7.00(m, 3H), 7.41(d, J=8.8Hz, 2H), 7.60(dd, J=8.8, 1.1Hz, 2H) 
               
               
                   
                 IR(KBr)1519, 1361, 1258, 1175, 1148, 1041, 978, 874cm −1   
               
               
                 I-117 
                 mp 168–170° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.79(s, 3H), 3.43(s, 3H), 3.63(d, J=0.9Hz, 3H), 3.89(s, 3H), 4.65(d, J=6.8Hz, 2H), 
               
               
                   
                 5.01(s, 1H), 5.57(t, J=6.8Hz, 1H), 5.65(s, 1H), 6.90–7.06(m, 5H), 7.43(dd, J=8.7, 1.5Hz, 2H) 
               
               
                   
                 IR(KBr)3433, 1523, 1464, 1397, 1253, 1216, 1038, 977, 838, 814cm −1   
               
               
                 I-1108 
                 mp 127–128° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.25(s, 3H), 2.27(s, 3H), 3.20(s, 3H), 5.22(s, 2H), 7.02(d, J=8.4Hz, 1H), 7.10(s, 1H), 7.11(s, 1H), 
               
               
                   
                 7.18(dd, J=2.1, 8.4Hz, 1H), 7.31–7.54(m, 10H) 
               
               
                   
                 IR(KBr)1513, 1484, 1369, 1284, 1243, 1175, 1150, 1061, 984, 968, 868, 847, 791, 718cm −1   
               
               
                 I-1109 
                 mp 161–162° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.26(s, 3H), 2.28(s, 3H), 5.16(s, 2H), 5.19(s, 2H), 5.70(br s, 1H), 6.82(dd, J=2.1, 8.4Hz, 1H), 6.96–7.16 
               
               
                   
                 (m, 7H), 7.31–7.51(m, 10H) 
               
               
                   
                 IR(KBr)3449, 1521, 1492, 1470, 1455, 1394, 1294, 1279, 1247, 1232, 1199, 1185, 1129, 1013, 740, 695cm −1   
               
               
                 I-110 
                 mp 133–134° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.26(s, 6H), 4.80(br s, 1H), 5.21(s, 2H), 6.85–6.93(m, 2H), 7.02(d, J=8.4Hz, 1H), 7.09(s, 1H), 7.17 
               
               
                   
                 (s, 1H), 7.15–7.52(m, 9H) 
               
               
                   
                 IR(KBr)3350, 1601, 1519, 1485, 1453, 1387, 1289, 1255, 1169, 1060, 839, 813, 731cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 219 
               
               
                   
               
             
            
               
                 I-1111 
                 mp 83–84° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.78(d, J=0.3Hz, 3H), 1.82(d, J=0.9Hz, 3H), 2.26(s, 3H), 2.27(s, 3H), 3.20(s, 3H), 4.65(d, J=6.6Hz, 
               
               
                   
                 2H), 5.55(m, 1H), 6.99(d, J=8.4Hz, 1H), 7.11(s, 1H), 7.12(s, 1H), 7.19(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=2.1Hz, 
               
               
                   
                 1H), 7.32–7.43(m, 4H) 
               
               
                   
                 IR(KBr)1514, 1485, 1364, 1286, 1253, 1197, 1178, 1156, 1057, 976, 882, 851cm −1   
               
               
                 I-1112 
                 mp 86–87° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(d, J=0.6Hz, 3H), 1.82(d, J=0.9Hz, 3H), 2.27(s, 6H), 4.65(d, J=6.6Hz, 2H), 5.00(s, 1H), 5.55 
               
               
                   
                 (m, 1H), 6.86–6.92(m, 2H), 6.98(d, J=8.4Hz, 1H), 7.10(s, 1H), 7.11(s, 1H), 7.20(dd, J=2.1, 8.4Hz, 1H), 7.22–7.26(m, 
               
               
                   
                 2H), 7.38(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr)3339, 1608, 1530, 1492, 1429, 1362, 1288, 1258, 1232, 1213, 1189, 1112, 889, 783cm −1   
               
               
                 I-1113 
                 amorphous 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 3.32(s, 6H), 3.44(s, 3H), 3.74(s, 3H), 5.23(s, 2H), 7.02(s, 1H), 7.14–7.20(m, 2H), 7.28(d, 
               
               
                   
                 J=8.7Hz, 1H), 7.32–7.55(m, 7H), 7.72(d, J=8.4Hz, 2H), 9.22(s, 1H), 
               
               
                   
                 IR(KBr)3382, 1684, 1518, 1469, 1365, 1237, 1150, 1017, 972, 872, 815cm −1   
               
               
                 I-1114 
                 mp 173–175° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 1.97(s, 3H), 3.19(s, 6H), 3.21(s, 3H), 3.37(s, 3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 
               
               
                   
                 2H), 5.50(t, J=6.9Hz, 1H), 6.85(m, 2H), 7.06(d, J=8.4Hz, 1H), 7.25(m, 1H), 7.37(br s, 1H), 7.66(d, J=8.7Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr)3421, 1518, 1470, 1366, 115, 1107, 970, 814cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 220 
               
               
                   
               
             
            
               
                 I-1115 
                 mp 96–98° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.77(s, 3H), 3.27(s, 3H), 3.59(s, 3H), 4.21(s, 2H), 4.55(d, J=6.3Hz, 2H), 5.50(t, J=6.3Hz, 
               
               
                   
                 1H), 6.17(s, 1H), 6.59(dd, J=8.1, 1.8Hz, 1H), 6.66(d, J=1.8Hz, 1H), 6.82(d, J=8.7Hz, 2H), 6.97(d, J=8.1Hz, 
               
               
                   
                 1H), 7.42(d, J=8.7Hz, 2H), 8.89(br s, 1H), 9.45(br s, 1H) 
               
               
                   
                 IR(KBr) 3431, 3396, 3319, 1611, 1521, 1486, 1264, 1172, 1111, 987, 826cm −1   
               
               
                 I-1116 
                 mp 186–188° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.76(s, 6H), 3.28(s, 3H), 3.68(s, 3H), 4.54(d, J=6.6Hz, 2H), 5.48(t, J=6.6Hz, 1H), 
               
               
                   
                 6.53–6.58(m, 1H), 6.65(d, J=1.8Hz, 1H), 6.83–6.89(m, 4H), 7.43(d, J=8.4Hz, 2H), 8.73(br s, 1H), 8.96(br s, 1H), 9.53 
               
               
                   
                 (br s, 1H) 
               
               
                   
                 IR(KBr) 3429, 1652, 1611, 1519, 1474, 1250, 1080, 1018, 981, 836cm −1   
               
               
                 I-1117 
                 mp 210–213° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.48(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 5.71(s, 1H), 5.85(s, 1H), 6.48(s, 1H), 6.95(dd, J=8.4, 2.1Hz, 
               
               
                   
                 1H), 7.04(d, J=8.4Hz, 1H), 7.07(d, J=2.1Hz, 1H), 7.40–7.48(m, 5H), 7.83(d, J=9.0Hz, 2H), 8.32(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr) 3499, 1511, 1343, 1284, 1247, 1195, 1109, 1070, 1013cm −1   
               
               
                 I-1118 
                 mp 156–158° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.67(s, 3H), 3.14(s, 3H), 3.56(s, 3H), 3.80(s, 3H), 5.20(s, 2H), 6.87(s, 1H), 7.16(d, J=8.7Hz, 1H), 
               
               
                   
                 7.32–7.48(m, 7H), 7.82(d, J=9.2Hz, 2H), 8.32(d, J=9.2Hz, 2H) 
               
               
                   
                 IR(KBr) 1518, 1479, 1350, 1177, 1119, 1079, 947, 816cm −1   
               
               
                 I-1119 
                 mp 173–175° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.24(s, 3H), 3.57(s, 3H), 3.80(s, 3H), 4.64(d, J=6.7Hz, 2H), 
               
               
                   
                 5.50(t, J=6.7Hz, 1H), 6.87(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.35(d, J=8.4, 2.1Hz, 1H), 7.39(d, J=2.0Hz, 1H), 7.82(d, J=9.0Hz, 
               
               
                   
                 2H), 8.32(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr) 1519, 1479, 1360, 1178, 1075, 946, 850, 799cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 221 
               
               
                   
               
             
            
               
                 I-1120 
                 mp 191–193° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 3.48(s, 3H), 3.77(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.53(t, J=6.6Hz, 1H), 
               
               
                   
                 5.72(s, 1H), 5.83(s, 1H), 6.48(s, 1H), 6.93(dd, J=8.1, 1.8Hz, 1H), 6.98(d, J=8.1Hz, 1H), 7.04(d, J=1.8Hz, 1H), 7.83(d, 
               
               
                   
                 J=9.0Hz, 2H), 8.32(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr) 3492, 1588, 1511, 1482, 1345, 1283, 1244, 1116, 1069, 1010cm −1   
               
               
                 I-1121 
                 mp 135–138° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.61(s, 3H), 3.67(s, 3H), 3.73(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.00(br. s, 
               
               
                   
                 1H), 5.50–5.57(m, 1H), 5.69(br. s, 1H), 6.65(s, 1H), 6.86–6.96(m, 4H), 7.00(d, J=1.8Hz, 1H), 7.48(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 3428, 2938, 1680, 1613, 1594, 1520, 1479, 1460, 1393, 1260, 1226, 1104, 1081, 993, 834cm −1   
               
               
                 I-1122 
                 mp 140–142° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.78(s, 3H), 1.82(s, 3H), 2.34(s, 3H), 4.65–4.67(d, J=6.9Hz, 2H), 5.55(m, 1H), 6.41–6.78(dt, J F-H=54.6, 
               
               
                   
                 3.3Hz, 2H), 7.05–7.25(m, 5H), 7.26–7.45(m, 2H), 7.75(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 1752, 1523, 1493, 1435, 1385, 1301, 1272, 1169, 1132, 1070, 1037, 916, 889cm −1   
               
               
                 I-1123 
                 mp 178–180° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.78–1.79(d, J=0.6Hz, 3H), 2.13(s, 3H), 3.50(s, 3H), 3.87(s, 3H), 4.63–4.65(d, J=6.6Hz, 
               
               
                   
                 2H), 5.00(br, 1H), 5.57(m, 1H), 5.75(s, 1H), 6.79(s, 1H), 6.84–7.00(m, 5H), 7.50–7.53(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 3528, 2937, 1612, 1584, 1522, 1489, 1454, 1400, 1259, 1173, 1139, 1102, 1009, 930, 865, 835cm −1   
               
               
                 I-1124 
                 mp 173–174° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.03(s, 6H), 3.54(s, 3H), 3.76(s, 3H), 3.91(s, 3H), 5.22(s, 2H), 6.80–6.99(m, 6H), 7.28–7.58(m, 7H) 
               
               
                   
                 IR(CHCl 3 ) 2938, 1731, 1609, 1527, 1485, 1442, 1394, 1365, 1174, 1141, 1082, 1037, 1013, 961, 936, 863cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 222 
               
               
                   
               
             
            
               
                 I-1125 
                 mp 103–106° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.78(s, 3H), 1.82–1.83(d, J=0.9Hz, 3H), 4.65–4.67(d, J=6.9Hz, 2H), 5.55(m, 1H), 6.41–6.78(td, J 
               
               
                   
                 F-H=54.9, 2.7Hz, 2H), 6.94–7.31(m, 7H), 7.73(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3592, 1612, 1525, 1495, 1385, 1301, 1263, 1187, 1173, 1132, 1069, 1036, 917, 889, 838cm −1   
               
               
                 I-1126 
                 mp 153–155° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.78–1.79(d, J=0.9Hz, 3H), 2.58(s, 3H), 3.03(s, 6H), 3.55(s, 3H), 3.77(s, 3H), 3.88(s, 
               
               
                   
                 3H), 4.61–4.64(d, J=6.9Hz, 2H), 5.54(m, 1H), 6.80–6.97(m, 6H), 7.54–7.57(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(CHCl 3 ) 2938, 1609, 1527, 1485, 1464, 1442, 1392, 1365, 1174, 1140, 1082, 1038, 1012, 961, 935cm −1   
               
               
                 I-1127 
                 mp 160–161° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.12(s, 3H), 3.49(s, 3H), 3.89(s, 3H), 4.89(br, 1H), 5.21(s, 2H), 5.76(s, 1H), 6.79–6.92(m, 5H), 7.00 
               
               
                   
                 (d, J=8.4Hz, 1H), 7.31–7.53(m, 7H) 
               
               
                   
                 IR(CHCl 3 ) 3594, 3517, 2937, 1731, 1612, 1589, 1522, 1489, 1455, 1400, 1327, 1259, 1240, 1173, 1139, 1102, 1011, 930, 865, 
               
               
                   
                 835cm −1   
               
               
                 I-1128 
                 mp 149–150° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.74–1.75(d, J=0.9Hz, 3H), 1.78–1.79(d, J=0.9Hz, 3H), 3.03(s, 1H), 3.49(s, 6H), 3.75(s, 3H), 3.88 
               
               
                   
                 s, 3H), 4.62–4.64(d, J=6.6Hz, 2H), 5.57(m, 1H), 5.95(s, 1H), 6.49(s, 1H), 6.81–6.84(m, 2H), 6.95–7.03(m, 3H), 7.55–7.58 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3509, 2937, 1675, 1610, 1584, 1528, 1492, 1464, 1397, 1362, 1323, 1197, 1175, 1140, 1117, 1078, 1038, 1011, 
               
               
                   
                 929, 835cm −1   
               
               
                 I-1129 
                 mp 163–165° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.15(s, 3H), 2.47(s, 3H), 3.20(s, 3H), 3.55(s, 3H), 3.90(s, 3H), 5.22(s, 2H), 6.80(dd, J=8.4, 2.1Hz, 
               
               
                   
                 1H), 6.88(d, J=2.1Hz, 1H), 7.00(d, J=8.4Hz, 1H), 7.17(s, 1H), 7.35–7.47(m, 7H), 7.66–7.69(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 2938, 1604, 1584, 1518, 1478, 1370, 1331, 1241, 1176, 1150, 1010, 987, 937, 872, 846cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 223 
               
               
                   
               
             
            
               
                 I-1130 
                 mp 142–144° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76–1.77(d, J=0.9Hz, 3H), 1.79–1.80(d, J=0.9Hz, 3H), 2.16(s, 3H), 2.60(s, 3H), 3.20(s, 3H), 3.57 
               
               
                   
                 (s, 3H), 3.88(s, 3H), 4.62–4.65(d, J=6.6Hz, 2H), 5.55(m, 1H), 6.83–6.87(m, 2H), 7.00(d, J=8.4Hz, 1H), 7.18(s, 1H), 
               
               
                   
                 7.35–7.38(m, 2H), 7.67–7.70(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 1604, 1582, 1517, 1478, 1416, 1370, 1332, 1240, 1176, 1150, 1093, 1008, 987, 936, 872cm −1   
               
               
                 I-1131 
                 mp 121–123° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.70(s, 3H), 1.71(s, 3H), 3.71–3.75(m, 4H), 3.75(s, 6H), 5.21–5.27(m, 2H), 5.54–5.59(m, 2H), 
               
               
                   
                 6.65–6.71(m, 2H), 6.95(s, 2H), 7.19–7.29(m, 4H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1627, 1536, 1497, 1470, 1454, 1375, 1341, 1257, 1208, 1125, 1053, 1035cm −1   
               
               
                 I-1132 
                 mp 169–170° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(d, J=0.6Hz, 3H), 1.81(d, J=0.9Hz, 3H), 2.26(s, 6H), 4.63(d, J=6.6Hz, 2H), 5.31(s, 1H), 5.34 
               
               
                   
                 (s, 1H), 5.55(m, 1H), 6.80(dd, J=2.1, 8.1Hz, 1H), 6.89(d, J=2.1Hz, 1H), 6.92(d, J=8.1Hz, 1H), 6.98–7.13(m, 5H) 
               
               
                   
                 IR(KBr) 3338, 1619, 1595, 1523, 1492, 1475, 1451, 1427, 1385, 1357, 1309, 1298, 1270, 1223, 1193, 1172, 1122, 1113, 999, 
               
               
                   
                 983, 871, 819, 785cm −1   
               
               
                 I-1133 
                 mp 135–136° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.14(t, J=6.9Hz, 3H), 2.42(s, 3H), 3.20(s, 3H), 3.73(q, J=6.9Hz, 2H), 3.77(s, 3H), 3.91(s, 3H), 
               
               
                   
                 5.22(s, 2H), 6.84(s, 1H), 6.91(dd, J=1.8, 8.4Hz, 1H), 6.98(d, J=8.4Hz, 1H), 6.98(d, J=1.8Hz, 1H), 7.28–7.47(m, 7H), 
               
               
                   
                 7.68–7.73(m, 2H) 
               
               
                   
                 IR(KBr) 1516, 1481, 1381, 1363, 1332, 1238, 1228, 1175, 1147, 1080, 1036, 865, 843, 800cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 224 
               
               
                   
               
             
            
               
                 I-1134 
                 mp 154–155° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.15(t, J=7.2Hz, 3H), 1.75(d, J=0.9Hz, 3H), 1.79(d, J=0.9Hz, 3H), 2.54(s, 3H), 3.21(s, 3H), 3.72 
               
               
                   
                 (q, J=7.2Hz, 2H), 3.78(s, 3H), 3.88(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.54(m, 1H), 6.85(s, 1H), 6.95–6.98(m, 3H), 7.34–7.40 
               
               
                   
                 (m, 2H), 7.68–7.74(m, 2H) 
               
               
                   
                 IR(KBr) 1519, 1481, 1467, 1365, 1335, 1245, 1231, 1184, 1157, 1081, 1038, 972, 889, 872, 840, 800cm −1   
               
               
                 I-1135 
                 mp 136–137° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.16(t, J=6.9Hz, 3H), 1.74(s, 3H), 1.78(s, 3H), 3.61(q, J=6.9Hz, 2H), 3.75(s, 3H), 3.88(s, 3H), 
               
               
                   
                 4.63(d, J=6.9Hz, 2H), 5.03(s, 1H), 5.57(m, 1H), 5.99(s, 1H), 6.46(s, 1H), 6.89–6.94(m, 2H), 6.97(d, J=8.7Hz, 1H), 7.01 
               
               
                   
                 (d, J=1.8Hz, 1H), 7.02(dd, J=1.8, 8.7Hz, 1H), 7.51–7.57(m, 2H) 
               
               
                   
                 IR(KBr) 3433, 1613, 1522, 1489, 1464, 1443, 1402, 1383, 1364, 1270, 1235, 1214, 1174, 1140, 1113, 1072, 1036, 983, 825cm −1   
               
               
                 I-1136 
                 mp 155–157° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.05(t, J=2.7Hz, 1H), 2.76(dt, J=6.3, 2.7Hz, 2H), 2.77(s, 3H), 3.21(s, 3H), 3.28(s, 3H), 3.56(s, 
               
               
                   
                 3H), 3.78(s, 3H), 4.23(t, J=6.3Hz, 2H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.36(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 
               
               
                   
                 2H), 7.41(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol) 3285, 1608, 1519, 1176, 1151, 1119, 1079, 970, 870, 815, 797cm −1   
               
               
                 I-1137 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.83(s, 3H), 2.58(t, J=6.6Hz, 2H), 2.74(s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 
               
               
                   
                 4.22(t, J=6.6Hz, 2H), 4.84(brs, 1H), 4.89(brs, 1H), 6.84(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.32–7.43(m, 4H), 7.68(d, J=8.7Hz, 
               
               
                   
                 2H), 
               
               
                   
                 IR(Nujol) 1608, 1519, 1176, 1150, 1119, 1078, 968, 869, 816cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 225 
               
               
                   
               
             
            
               
                 I-1138 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.81(s, 3H), 2.55(t, J=6.6Hz, 2H), 3.45(s, 3H), 3.74(s, 3H), 4.20(t, J=6.6Hz, 2H), 4.85(brs, 1H), 
               
               
                   
                 4.89(brs, 1H), 6.45(s, 1H), 6.86–7.07(m, 5H), 7.53(d, J=8.7Hz, 2H), 
               
               
                   
                 IR(Nujol) 3531, 3328, 1612, 1587, 1523, 1489, 1287, 1226, 1115, 1072, 1011cm −1   
               
               
                 I-1139 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.07(t, J=2.7Hz, 1H), 2.72(dt, J=6.6, 2.7Hz, 2H), 3.45(s, 3H), 3.75(s, 3H), 4.21(t, J=6.6Hz, 2H), 
               
               
                   
                 6.45(s, 1H), 6.87–7.10(m, 5H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol) 3482, 3305, 1609, 1597, 1527, 1494, 1253, 1240, 1227, 1127, 1118, 1079, 1010cm −1   
               
               
                 I-1140 
                 m.p 194–197° C. 
               
               
                   
                   1 H NMR(DMSO) δ 3.29(s, 3H), 3.64(s, 3H), 5.42(s, 2H), 6.38(s, 1H), 6.61(dd, J=2.0, 8.2Hz, 1H), 6.74(d, J=2.0Hz, 
               
               
                   
                 1H), 6.84(d, J=8.6Hz, 2H), 6.96(d, J=8.2Hz, 1H), 7.19(d, J=7.8Hz, 1H), 7.41(d, J=7.8Hz, 1H), 7.43(d, J=8.4Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3432, 1611, 1566, 1523, 1488, 1430, 1400, 1380, 1241, 1113, 1071, 814cm −1   
               
               
                 I-1141 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), d 3.75(s, 3H), 3.92(s, 3H), 5.53(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.94(dd, J=2.1, 
               
               
                   
                 8.7Hz, 1H), 7.01(d, J=8.7Hz, 1H), 7.10(d, J=2.1Hz, 1H), 7.28(d, J=4.8Hz, 1H), 7.52(d, J=4.8Hz, 1H), 7.53(d, J=8.4Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3423, 1702, 1684, 1611, 1523, 1489, 1439, 1402, 1282, 1112, 1073, 1010, 814cm −1   
               
               
                 I-1142 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.74(s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.55(s, 3H), d 3.78(s, 3H), 3.91(s, 3H), 5.19(s, 2H), 6.60(d, J=3.6Hz, 
               
               
                   
                 1H), 6.84(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.17(d, J=3.6Hz, 1H), 7.36(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.7Hz, 
               
               
                   
                 2H), 7.41(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1728, 1519, 1481, 1365, 1177, 1150, 1079, 969, 876, 797cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 226 
               
               
                   
               
             
            
               
                 I-1143 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.77(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.56(s, 3H), d 3.78(s, 3H), 4.18(m, 2H), 4.78(m, 2H), 5.94(m, 
               
               
                   
                 2H), 6.84(s, 1H), 7.11(d, J=8.4Hz, 1H), 7.36(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H), 
               
               
                   
                 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1609, 1519, 1481, 1367, 1177, 1150, 1079, 970, 876, 797cm −1   
               
               
                 I-1144 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.75(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.55(s, 3H), d 3.78(s, 3H), 4.11(m, 2H), 4.64(m, 2H), 6.05(t, J=4.5Hz, 
               
               
                   
                 1H), 6.06(t, J=5.1Hz, 1H), 6.84(s, 1H), 7.07(d, J=8.7Hz, 1H), 7.35(dd, J=2.1, 8.7Hz, 1H), 7.38(d, J=8.7Hz, 
               
               
                   
                 2H), 7.40(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1609, 1519, 1481, 1364, 1177, 1151, 1079, 969, 874, 797cm −1   
               
               
                 I-1145 
                 m.p 203–205° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.83(s, 3H), 3.22(s, 3H), 3.25(s, 3H), 3.55(s, 3H), d 3.79(s, 3H), 4.30(t, J=1.8Hz, 2H), 4.88(t, J=1.8Hz, 
               
               
                   
                 2H), 6.84(s, 1H), 7.20(d, J=8.7Hz, 1H), 7.37(dd, J=2.1, 8.7Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 
               
               
                   
                 1H), 7.67(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3443, 1606, 1519, 1481, 1360, 1179, 1150, 1079, 877, 798cm −1   
               
               
                 I-1146 
                 m.p 173–174° C. 
               
               
                   
                   1 H NMR(CD3OD) δ 3.38(s, 3H), 3.68(s, 3H), 4.23(t, J=1.8Hz, 2H), 4.83(t, J=1.8Hz, 2H), 6.43(s, 1H), 6.79(dd, J=2.1, 
               
               
                   
                 8.1Hz, 1H), 6.85(d, J=8.7Hz, 2H), 6.86(d, J=2.1Hz, 1H), 7.04(d, J=8.1Hz, 1H), 7.45(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3399, 1612, 1586, 1523, 1487, 1401, 1217, 1114, 1067, 1013, 996, 828cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 227 
               
               
                   
               
             
            
               
                 I-1147 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.39(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.17(t, J=1.8Hz, 2H), 4.83(t, J=1.8Hz, 2H), 6.45(s, 1H), 
               
               
                   
                 6.91(d, J=8.7Hz, 2H), 6.97(dd, J=2.1, 8.1Hz, 1H), 7.05(d, J=8.1Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.52(d, J=8.7Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3411, 1612, 1589, 1523, 1489, 1404, 1224, 1114, 1071, 1010, 939, 816cm −1   
               
               
                 I-1148 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.14(t, J=7.5Hz, 3H), 2.23(q, J=7.5Hz, 2H), 2.71(s, 3H), 3.21(s, 3H), 3.27(s, 3H), 3.60(s, 3H), 
               
               
                   
                 3.78(s, 3H), 4.80(s, 2H), 6.84(s, 1H), 7.20(d, J=9.0Hz, 1H), 7.37(dd, J=2.1, 9.0Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.42(d, 
               
               
                   
                 J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 2232, 1609, 1519, 1481, 1365, 1177, 1151, 1079, 970, 876, 797cm −1   
               
               
                 I-1149 
                 mp &gt; 280° C.(decomp.) 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 3.30(s, 3H), 3.64(s, 3H), 4.85(s, 2H), 6.39(s, 1H), 6.69(dd, J=8.4, 2.1Hz, 1H), 6.79(d, J=2.1Hz, 
               
               
                   
                 1H), 6.84(d, J=8.7Hz, 2H), 6.94(d, J=8.4Hz, 1H), 7.44(d, J=8.7Hz, 2H), 8.54(s, 1H) 
               
               
                   
                 IR(Nujol) 3166, 1707, 1671, 1611, 1586, 1523, 1489, 1288, 1259, 1211, 1115, 1075, 1012, 814cm −1   
               
               
                 I-1150 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.91(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.89(s, 2H), 5.29(brs, 1H), 5.36(brs, 1H), 6.45(s, 1H), 6.92(d, 
               
               
                   
                 J=8.7Hz, 2H), 6.97(dd, J=8.4, 2.1Hz, 1H), 7.07(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.54(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3432, 1612, 1588, 1523, 1489, 1288, 1224, 1192, 1113, 1070, 1010, 938, 825, 813cm −1   
               
               
                 I-1151 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 4.98(d, J=1.8Hz, 2H), 5.92(dt, J=7.5, 1.8Hz, 1H), 6.45(s, 1H), 6.46(d, J=7.5Hz, 
               
               
                   
                 1H), 6.92(d, J=8.7Hz, 2H), 6.98(dd, J=8.4, 2.1Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.11(d, J=8.4Hz, 1H), 7.53 
               
               
                   
                 (d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3410, 1612, 1589, 1523, 1489, 1403, 1224, 1112, 1070, 1011, 938, 826cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 228 
               
               
                   
               
             
            
               
                 I-1152 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 4.89(d, J=2.1Hz, 2H), 5.97(dt, J=13.8, 2.1Hz, 1H), 6.45(s, 1H), 6.61(d, J=13.8Hz, 
               
               
                   
                 1H), 6.92(d, J=8.7Hz, 2H), 6.97(dd, J=8.4, 2.1Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.54 
               
               
                   
                 (d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3427, 1612, 1588, 1523, 1489, 1403, 1226, 1192, 1175, 1113, 1070, 1011, 938, 918, 826cm −1   
               
               
                 I-1153 
                 mp 188–189° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.84(s, 3H), 3.33(s, 3H), 3.74(s, 3H), 3.98(s, 3H), 4.18(s, 3H), 5.38(s, 2H), 7.05(s, 1H), 7.36–7.64(m, 
               
               
                   
                 10H), 8.61(d, J=8.7Hz, 1H), 8.82(brs, 1H) 
               
               
                   
                 IR(KBr) 3381, 2942, 1724, 1538, 1481, 1369, 1296, 1177, 1163, 1082, 963, 821cm −1   
               
               
                 I-1154 
                 mp 78–80° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.17(s, 3H), 2.67(s, 3H), 3.13(s, 3H), 3.57(s, 3H), 3.79(s, 3H), 5.19(s, 2H), 6.83(s, 1H), 7.15(d, J=8.6Hz, 
               
               
                   
                 1H), 7.31–7.45(m, 7H), 7.62(d, J=8.2Hz, 1H), 7.79(s, 1H), 8.44(d, J=8.6Hz, 1H), 8.51(brs, 1H) 
               
               
                   
                 IR(KBr) 3398, 2939, 1739, 1529, 1477, 1368, 1287, 1240, 1177, 1119, 1078, 957, 815, 796, 522cm −1   
               
               
                 I-1155 
                 mp 74–75° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.68(s, 3H), 1.76(s, 6H), 1.81(s, 3H), 2.69(s, 3H), 3.24(s, 3H), 3.52(s, 3H), 3.80(s, 3H), 3.88(s, 3H), 
               
               
                   
                 3.88–4.02(m, 2H), 4.64(d, J=7.2Hz, 2H), 5.25(t, J=7.8Hz, 1H), 5.50(t, J=5.7Hz, 1H), 6.88(s, 1H), 7.08–7.38(m, 6H) 
               
               
                   
                 IR(KBr) 3412, 2939, 1697, 1519, 1483, 1366, 1268, 1207, 1178, 1080, 964, 808, 523cm −1   
               
               
                 I-1156 
                 mp 72–74° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.95(s, 3H), 1.99(s, 3H), 2.87(s, 3H), 3.42(s, 3H), 3.74(s, 3H), 3.97(s, 3H), 4.16(s, 3H), 4.82(d, J=6.6Hz, 
               
               
                   
                 2H), 5.68(t, J=5.7Hz, 1H), 7.04(s, 1H), 7.27(d, J=8.1Hz, 1H), 7.39–7.56(m, 4H), 8.60(d, J=8.4Hz, 1H), 8.81 
               
               
                   
                 (brs, 1H) 
               
               
                   
                 IR(KBr) 3407, 2940, 1731, 1601, 1538, 1481, 1366, 1294, 1178, 1165, 1079, 805, 562cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 229 
               
               
                   
               
             
            
               
                 I-1157 
                 mp 68–69° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.70(s, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.70(s, 3H), 3.25(s, 3H), 3.55(s, 3H), 3.81(s, 3H), 4.64(d, J=6.6Hz, 
               
               
                   
                 2H), 5.27(t, J=7.5Hz, 1H), 5.50(t, J=6.9Hz, 1H), 6.86(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.25–7.40(m, 3H), 7.57(d, 
               
               
                   
                 J=8.1Hz, 1H), 7.76(s, 1H) 
               
               
                   
                 IR(KBr) 3422, 2939, 1701, 1519, 1480, 1368, 1203, 1177, 1078, 957, 801, 522cm −1   
               
               
                 I-1158 
                 mp 64–66° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.47(s, 3H), 3.74(s, 3H), 5.19(s, 2H), 5.86(brs, 1H), 6.44(s, 1H), 7.08–7.69(m, 11H), 8.06(brs, 1H) 
               
               
                   
                 IR(KBr) 3399, 2938, 1726, 1624, 1604, 15263, 1487, 1403, 1302, 1208, 1178, 1068, 695, 520cm −1   
               
               
                 I-119 
                 mp 68–70° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.57(s, 3H), 3.57(s, 3H), 3.76(s, 3H), 5.21(s, 2H), 6.84(s, 1H), 7.11–7.73(m, 11H), 8.29(brs, 1H) 
               
               
                   
                 IR(KBr) 3422, 2939, 1728, 1605, 1523, 1482, 1397, 1367, 1233, 1209, 1178, 1078, 795, 725, 542cm −1   
               
               
                 I-1160 
                 mp 72–73° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 6H), 1.78(s, 3H), 1.82(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 3.76(d, J=7.2Hz, 2H), 3.89(s, 3H), 
               
               
                   
                 4.38(brs, 1H), 4.61(d, J=6.9Hz, 2H), 5.41(t, J=6.3Hz, 1H), 5.53(t, J=6.9Hz, 1H), 5.68(brs, 1H), 5.94(brs, 1H), 6.49(s, 
               
               
                   
                 3H), 6.69(d, J=8.4Hz, 1H), 6.95(s, 1H), 7.06(s, 1H), 7.13–7.15(m, 2H), 7.26(s, 1H) 
               
               
                   
                 IR(KBr) 3423, 2932, 1608, 1528, 1490, 1459, 1250, 1113, 1071, 805, 757cm −1   
               
               
                 I-1161 
                 mp 68–69° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 3.91(s, 3H), 4.61(d, J=7.2Hz, 2H), 5.53(t, J=6.0Hz, 
               
               
                   
                 1H), 5.91(brs, 2H), 6.47(s, 1H), 6.83(d, J=8.1Hz, 2H), 6.95(s, 1H), 7.06–7.09(m, 2H), 7.16(s, 1H), 7.26(s, 1H) 
               
               
                   
                 IR(KBr) 3406, 2933, 1524, 1490, 1397, 1270, 1241, 1116, 1075, 1069, 811, 773cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 230 
               
               
                   
               
             
            
               
                 I-1162 
                 mp 81–83° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 6H), 1.79(s, 3H), 1.81(s, 3H), 3.50(s, 3H), 3.75(s, 3H), 3.80(d, J=6.6Hz, 2H), 4.36(brs, 1H), 
               
               
                   
                 4.61(d, J=6.9Hz, 2H), 5.39(t, J=6.3Hz, 1H), 5.53(t, J=6.6Hz, 1H), 5.68(brs, 1H), 5.90(brs, 1H), 6.43(s, 1H), 6.73(d, J=8.4Hz, 
               
               
                   
                 1H), 6.95(s, 1H), 7.05(s, 1H), 7.26(d, J=0.9Hz, 1H), 7.47(dd, J=2.1, 8.4Hz, 1H), 7.59(d, J=2.1Hz, 1H) 
               
               
                   
                 IR(KBr) 3484, 2931, 1607, 1525, 1488, 1310, 1243, 1114, 1070, 1009, 808cm −1   
               
               
                 I-1163 
                 mp 87–89° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.81(s, 3H), 3.60(s, 3H), 3.77(s, 3H), 3.98(d, J=6.3Hz, 2H), 4.80(d, J=6.3Hz, 2H), 6.07(t, J=6.0Hz, 
               
               
                   
                 1H), 6.25(t, J=6.3Hz, 1H), 6.46–6.53(m, 2H), 6.86(s, 1H), 7.05–7.38(m, 4H) 
               
               
                   
                 IR(KBr) 3411, 2937, 1628, 1527, 1482, 1364, 1233, 1176, 1077, 960, 879, 792, 524cm −1   
               
               
                 I-1164 
                 amorphous 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.68(s, 3H), 3.13(s, 3H), 3.43(s, 3H), 3.54(s, 3H), 3.80(s, 3H), 5.19(s, 2H), 6.87(s, 1H), 7.16(d, J=8.7Hz, 
               
               
                   
                 1H), 7.32–7.49(m, 9H), 7.69(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 1698, 1522, 1482, 1367, 1080, 1014, 947, 815, 795cm −1   
               
               
                 I-1165 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.47(s, 3H), 1.72(s, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.24(s, 3H), 3.51(s, 3H), 3.80(s, 3H), 
               
               
                   
                 4.37(d, J=7.8Hz, 2H), 4.64(d, J=6.6Hz, 2H), 5.29(t, J=7.8Hz, 1H), 5.50(t, J=6.6Hz, 1H), 6.88(s, 1H), 7.09(d, J=8.4Hz, 
               
               
                   
                 1H), 7.27(d, J=8.7Hz, 2H), 7.35(dd, J=8.4, 2.3Hz, 1H), 7.39(d, J=2.3Hz, 1H), 7.66(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1696, 1521, 1482, 1366, 1177, 1080, 972, 946, 814, 795cm −1   
               
               
                 I-1166 
                 mp 135–136° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.24(s, 3H), 3.54(s, 3H), 3.80(s, 3H), 4.64(d, J=6.7Hz, 2H), 
               
               
                   
                 5.50(t, J=6.7Hz, 1H), 6.87(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.34(d, J=8.1Hz, 2H), 7.35(dd, J=8.4, 2.2Hz, 1H), 7.39(d, J=2.2Hz, 
               
               
                   
                 1H), 7.69(d, J=8.1Hz, 2H) 
               
               
                   
                 IR(KBr) 1702, 1522, 1481, 1362, 1275, 1150, 1081, 1014, 978, 817, 793cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 231 
               
               
                   
               
             
            
               
                 I-1167 
                 mp 169–171° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.71(s, 3H), 1.72(s, 6H), 1.76(s, 3H), 3.31(s, 3H), 3.63(s, 3H), 3.64(m, 2H), 4.54(d, J=6.8Hz, 
               
               
                   
                 2H), 5.29(t, J=7.5Hz, 1H), 5.49(t, J=6.8Hz, 1H), 5.75(t, J=8.1Hz, 1H), 6.37(s, 1H), 6.63(d, J=8.4Hz, 2H), 6.64(dd, J=8.1, 
               
               
                   
                 2.0Hz, 1H), 6.73(d, J=2.0Hz, 1H), 6.88(d, J=8.4Hz, 2H), 7.37(d, J=8.4Hz, 2H), 8.41(s, 1H), 8.70(s, 1H) 
               
               
                   
                 IR(KBr) 3473, 3276, 1608, 1523, 1491, 1310, 1252, 1190, 1112, 1072, 934, 824, 776cm −1   
               
               
                 I-1168 
                 mp 159–160° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.76(s, 3H), 3.31(s, 3H), 3.64(s, 3H), 4.54(d, J=6.8Hz, 2H), 5.49(t, J=6.8Hz, 1H), 
               
               
                   
                 5.76(br s, 1H), 6.37(s, 1H), 6.61(d, J=8.4Hz, 2H), 6.64(dd, J=8.1, 2.0Hz, 1H), 6.73(d, J=2.0Hz, 1H), 6.88(d, J=8.1Hz, 
               
               
                   
                 1H), 7.39(d, J=8.4Hz, 2H), 7.37(d, J=8.4Hz, 2H), 8.42(br s, 1H), 8.70(br s, 1H) 
               
               
                   
                 IR(KBr) 3458, 3332, 1609, 1524, 1492, 1411, 1393, 1295, 1234, 1107, 1071, 1012, 994, 781cm −1   
               
               
                 I-1169 
                 mp 183–184° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(d, J=0.6Hz, 3H), 1.82(s, 3H), 3.13(s, 3H), 3.48(s, 3H), 3.76(s, 3H), 4.63(d, J=6.9Hz, 2H), 
               
               
                   
                 5.53(m, 1H), 5.72(s, 1H), 5.83(s, 1H), 6.46(s, 1H), 6.93(dd, J=1.8, 8.4Hz, 1H), 6.98(d, J=8.4Hz, 1H), 7.04(d, J=1.8Hz, 
               
               
                   
                 1H), 7.82–7.89(m, 2H), 8.00–8.06(m, 2H) 
               
               
                   
                 IR(KBr) 3445, 1593, 1499, 1482, 1461, 1387, 1311, 1278, 1245, 1189, 1146, 1111, 1086, 1068, 1010, 997, 942, 766cm −1   
               
               
                 I-1170 
                 mp 178–179° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 2.80(s, 3H), 3.47(s, 3H), 3.76(s, 3H), 4.62(d, J=7.2Hz, 2H), 5.53(m, 1H), 
               
               
                   
                 5.72(s, 1H), 5.86(s, 1H), 6.47(s, 1H), 6.94(dd, J=1.8, 8.1Hz, 1H), 6.98(d, J=8.1Hz, 1H), 7.05(d, J=1.8Hz, 1H), 7.72–7.77 
               
               
                   
                 (m, 2H), 7.79–7.85(m, 2H) 
               
               
                   
                 IR(KBr) 3420, 1587, 1527, 1482, 1449, 1430, 1416, 1390, 1357, 1290, 1240, 1214, 1198, 1135, 1115, 1073, 1019, 998, 975, 
               
               
                   
                 962, 937, 831cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 232 
               
               
                   
               
             
            
               
                 I-1171 
                 mp 136–139° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.73(s, 3H), 1.77(s, 3H), 2.99(s, 6H), 3.71(d, J=6.6Hz, 2H), 3.76(s, 3H), 3.78(s, 3H), 5.32–5.37(m, 
               
               
                   
                 1H), 6.36–6.46(m, 2H), 6.79–6.84(m, 2H), 6.89(s, 1H), 6.95(s, 1H), 7.18–7.24(m, 1H), 7.47–7.52(m, 2H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1626, 1609, 1531, 1493, 1460, 1444, 1388, 1345, 1232, 1207, 1173, 1124, 1050, 1028cm −1   
               
               
                 I-1172 
                 mp 113–114° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.00(s, 6H), 3.77(s, 3H), 3.78(s, 3H), 6.78–6.84(m, 2H), 6.88(s, 1H), 6.98(s, 1H), 7.31(dd, J=2.1, 
               
               
                   
                 8.4Hz, 1H), 7.43–7.53(m, 3H), 7.58(dd, J=1.8, 11.1Hz, 1H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1711, 1609, 1533, 1493, 1464, 1390, 1212, 1181, 1162, 1052, 1027cm −1   
               
               
                 I-1173 
                 mp 141–143° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(d, J=0.9Hz, 3H), 1.78(d, J=0.9Hz, 3H), 2.99(s, 6H), 3.50(s, 3H), 3.74(s, 3H), 3.78(d, J=6.6Hz, 
               
               
                   
                 2H), 3.93(br, 1H), 5.35–5.40(m, 1H), 5.86(s, 1H), 6.44(s, 1H), 6.74–6.86(m, 3H), 7.30–7.38(m, 4H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1625, 1611, 1530, 1491, 1458, 1444, 1400, 1348, 1333, 1250, 1217, 1103, 1075cm −1   
               
               
                 I-1174 
                 mp 226–228° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.93(s, 3H), 4.95(s, 1H), 5.21(s, 2H), 6.90–6.94(m, 2H), 6.96(s, 1H), 6.97(s, 1H), 7.03(d, J=0.9Hz, 
               
               
                   
                 1H), 7.30–7.49(m, 1H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1608, 1589, 1520, 1471, 1446, 1384, 1358, 1270, 1250, 1238, 1210, 1172, 1141, 1093, 1031, 997cm −1   
               
               
                 I-1175 
                 mp 143–145° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.21(s, 3H), 3.93(s, 3H), 5.22(s, 2H), 6.97(s, 2H), 7.03(s, 1H), 7.30–7.55(m, 11H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1602, 1517, 1468, 1368, 1348, 1248, 1210, 1176, 1151, 1095, 1038, 989cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 233 
               
               
                   
               
             
            
               
                 I-1176 
                 mp 98–100° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.79(s, 3H), 3.21(s, 3H), 3.91(s, 3H), 4.65(d, J=6.9Hz, 2H), 5.53–5.58(m, 1H), 6.94–7.03 
               
               
                   
                 (m, 3H), 7.23–7.41(m, 2H), 7.45(s, 1H), 7.49(s, 1H), 7.51–7.56(m, 1H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1604, 1583, 1519, 1470, 1449, 1365, 1250, 1202, 1177, 1151, 1095, 1041, 972cm −1   
               
               
                 I-1177 
                 mp 118–120° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.79(s, 3H), 3.91(s, 3H), 4.64(d, J=6.9Hz, 2H), 5.53–5.58(m, 1H), 6.88–7.02(m, 5H), 
               
               
                   
                 7.23–7.37(m, 2H), 7.44(s, 1H), 7.46(s, 1H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1626, 1609, 1526, 1490, 1429, 1253, 1187cm −1   
               
               
                 I-1178 
                 mp 161–164° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.00(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 6.78–6.83(m, 2H), 6.90(s, 1H), 6.97(s, 1H), 7.47–7.52(m, 2H), 
               
               
                   
                 7.71(d, J=1.8Hz, 1H), 8.37(d, J=8.7Hz, 1H), 8.46(br s, 1H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1716, 1613, 1532, 1505, 1487, 1463, 1384, 1357, 1280, 1195, 1172, 1059, 1033cm −1   
               
               
                 I-1179 
                 mp 135–137° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.74(s, 3H), 1.78(s, 3H), 3.00(s, 6H), 3.78(s, 3H), 3.79(s, 3H), 4.29(d, J=6.6Hz, 1H), 5.35–5.40(m, 
               
               
                   
                 1H), 6.71(d, J=8.4Hz, 1H), 6.80–6.83(m, 2H), 6.90(s, 1H), 6.94(s, 1H), 7.38–7.42(m, 1H), 7.48–7.56(m, 3H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1612, 1532, 1495, 1460, 1444, 1385, 1365, 1273, 1257, 1203, 1059, 1039, 1029cm −1   
               
               
                 I-1180 
                   1 H NMR(CDCl 3 ) δ 1.57(d, J=6.3Hz, 3H), 2.26(s, 3H), 2.28(s, 3H), 5.18(s, 2H), 5.22(q, J=6.3Hz, 1H), 7.02(d, J=8.4Hz, 
               
               
                   
                 1H), 7.12(s, 1H), 7.15(s, 1H), 7.23(d.d, J=8.4 &amp; 2.1Hz, 1H), 7.30–7.51(m, 10H) 
               
               
                   
                 IR(KBr) 3557, 1605, 1486, 1370, 1235, 1177, 1149, 1078, 1017cm −1   
               
               
                 I-1181 
                   1 H NMR(CDCl 3 ) δ 1.66(s, 6H), 2.27(s, 3H), 2.28(s, 3H), 3.20(s, 3H), 4.22(s, 1H), 5.22(s, 2H), 7.06(d, J=8.4Hz, 1H), 
               
               
                   
                 7.12(s, 1H), 7.14(s, 1H), 7.23(d.d, J=8.4 &amp; 2.1Hz, 1H), 7.30–7.51(m, 10H) 
               
               
                   
                 IR(KBr) 3544, 3441, 1604, 1512, 1485, 1367, 1222, 1173, 1149cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 234 
               
               
                   
               
             
            
               
                 I-1182 
                   1 H NMR(CDCl 3 ) δ 1.28(t, J=7.2Hz, 3H), 2.26(s, 3H), 2.28(s, 3H), 2.70(q, J=7.2Hz, 2H), 3.20(s, 3H), 4.73(s, 1H), 6.82 
               
               
                   
                 (d, J=8.4Hz, 1H), 7.03–7.11(m, 2H), 7.14(s, 1H), 7.15(s, 1H), 7.29–7.46(m, 4H) 
               
               
                   
                 IR(KBr) 3510, 1605, 1515, 1488, 1369, 1263, 1177, 1147, 1117cm −1   
               
               
                 I-1183 
                   1 H NMR(CDCl 3 ) δ 1.29(d, J=6.9Hz, 6H), 2.27(s, 3H), 2.28(s, 3H), 3.20(s, 3H), 3.27(qintet, J=6.9Hz, 1H), 4.76(s, 1H), 
               
               
                   
                 6.81(d, J=7.8Hz, 1H), 7.07(d.d, J=7.8 &amp; 2.1Hz, 1H), 7.11(s, 1H), 7.15(s, 1H), 7.20(d, J=2.1Hz, 1H), 7.34(d, J=8.7Hz, 
               
               
                   
                 2H), 7.42(d, J=8.7Hz, 2H), 
               
               
                   
                 IR(KBr) 3511, 1606, 1484, 1356, 1174, 1151cm −1   
               
               
                 I-1184 
                   1 H NMR(CDCl 3 ) δ 1.23(t, J=8.1Hz, 3H), 1.77(s, 3H), 1.82(s, 3H), 2.26(s, 3H), 2.29(s, 3H), 2.70(q, J=8.1Hz, 2H), 3.20 
               
               
                   
                 (s, 3H), 4.58(d, J=6.6Hz, 2H), 5.48–5.57(m, 1H), 6.90(d, J=7.8Hz, 1H), 7.08–7.13(m, 2H), 7.16(s, 2H), 7.23–7.47(m, 
               
               
                   
                 4H) 
               
               
                   
                 IR(KBr) 1605, 1485, 1369, 1352, 1236, 1201, 1174, 1150, 1133, 1008cm −1   
               
               
                 I-1185 
                   1 H NMR(CDCl 3 ) δ 1.23(t, J=7.5Hz, 3H), 1.76(s, 3H), 1.81(s, 3H), 2.27(s, 3H), 2.29(s, 3H), 2.70(q, J=7.5Hz, 2H), 
               
               
                   
                 4.57(d, J=6.6Hz, 2H), 4.79(brs, 1H), 5.49–5.58(m, 1H), 6.83–6.92(m, 3H), 7.08–7.19(m, 4H), 7.27(.d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 3529, 1608, 1519, 1487, 1241, 1136, 1024cm −1   
               
               
                 I-1186 
                   1 H NMR(CDCl 3 ) δ 1.23(d, J=1.8Hz, 6H), 1.76(s, 3H), 1.82(s, 3H), 2.27(s, 3H), 2.29(s, 3H), 3.20(s, 3H), 3.40(quintet, 
               
               
                   
                 J=1.8Hz, 1H), 4.58(d, J=6.6Hz, 2H), 5.48–5.59(m, 1H), 6.90(d, J=7.8Hz, 1H), 7.10–7.44(m, 8H) 
               
               
                   
                 IR(KBr) 1602, 1468, 1369, 1232, 1174, 1151cm −1   
               
               
                 I-1187 
                   1 H NMR(CDCl 3 ) δ 1.24(d, J=6.9Hz, 6H), 1.76(s, 3H), 1.81(s, 3H), 2.27(s, 3H), 2.29(s, 3H), 3.40(quintet, J=6.9Hz, 
               
               
                   
                 1H), 4.58(d, J=6.6Hz, 2H), 4.79(broad, s., 1H), 5.50–5.57(m, 1H), 6.84–6.93(m, 3H), 7.09–7.16(m, 3H), 7.00–7.28 
               
               
                   
                 (m, 3H) 
               
               
                   
                 IR(KBr) 3265, 1607, 1519, 1486, 1448, 1383, 1232, 1170cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 235 
               
               
                   
               
             
            
               
                 I-1188 
                   1 H NMR(CDCl 3 ) δ 1.31(d, J=6.9Hz, 6H), 1.44(s, 3H), 1.67(s, 3H), 2.97(quintet, J=6.9Hz, 1H), 3.78(s, 3H), 3.80(s, 
               
               
                   
                 3H), 3.92(s, 3H), 4.20–4.30(broad, 1H), 5.17–5.30(m, 1H), 6.96(s, 1H), 6.99(s, 1H), 7.07–7.35(m, 5H), 7.52(d, J=8.1Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3422, 1601, 1529, 1492, 1462, 1378, 1341, 1257, 1203, 1138, 1028cm −1   
               
               
                 I-1189 
                   1 H NMR(CDCl 3 ) δ 2.67(s, 3H), 3.13(s, 3H), 3.57(s, 3H), 3.79(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 7.15(d, J=9.0Hz, 1H), 
               
               
                   
                 7.31–7.50(m, 8H), 7.55(d.d, J=12.0 &amp; 1.8Hz, 1H), 8.34–8.41(m, 1H) 
               
               
                   
                 IR(KBr) 3428, 1740, 1601, 1535, 1482, 1366, 1292, 1238, 1177, 1164, 1112, 1079, 1013cm −1   
               
               
                 I-1190 
                   1 H NMR(CDCl 3 ) δ 1.48(s, 3H), 1.70(s, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.70(s, 3H), 3.24(s, 3H), 3.55(s, 3H), 3.81(s, 
               
               
                   
                 3H), 4.09–4.20(m, 1H), 4.53–4.68(m, 3H), 5.18–5.30(m, 1H), 5.43–5.54(m, 1H), 6.86(s, 1H), 7.06–7.51(m, 6H) 
               
               
                   
                 IR(KBr) 1702, 1521, 1482, 1367, 1204, 1177, 1115, 1080cm −1   
               
               
                 I-1191 
                   1 H NMR(CDCl 3 ) δ 1.75(s, 6H), 1.78(s, 3H), 1.82(s, 3H), 3.49(s, 3H), 3.74(s, 3H), 3.79(d, J=6.3Hz, 2H), 4.61(d, J=6.6Hz, 
               
               
                   
                 2H), 5.32–5.43(m, 1H), 5.49–5.57(m, 1H), 5.68(s, 1H), 5.90(s, 1H), 6.44(s, 1H), 6.74–6.85(m, 1H), 6.95(s, 2H), 
               
               
                   
                 7.05(s, 1H), 7.29–7.38(m, 2H) 
               
               
                   
                 IR(KBr) 3527, 1624, 1530, 1491, 1248, 1221, 1197, 1125, 1105, 1072cm −1   
               
               
                 I-1192 
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.78(s, 3H), 3.49(s, 3H), 3.73(s, 3H), 3.78(d, J=6.9Hz, 2H), 5.32–5.43(m, 1H), 
               
               
                   
                 6.44(s, 1H), 6.73–6.97(m, 4H), 7.25–7.37(m, 2H) 
               
               
                   
                 IR(KBr) 3551, 3437, 3310, 1607, 1529, 1491, 1463, 1402, 1362, 1269, 1255, 1184, 1099, 1070, 1013cm −1   
               
               
                 I-1193 
                   1 H NMR(CDCl 3 ) δ 2.28(s, 3H), 2.30(s, 3H), 3.00(s, 6H), 5.16(s, 2H), 5.69(s, 1H), 6.80(d, J=8.7Hz, 2H), 6.84(d.d, 
               
               
                   
                 J=8.1 &amp; 2.1Hz, 1H), 6.98(d, J=8.1Hz, 1H), 6.99(d, J=2.1Hz, 1H), 7.12(s, 1H), 7.13(s, 1H), 7.27(d, J=8.7Hz, 2H), 
               
               
                   
                 7.34–7.50(m, 5H) 
               
               
                   
                 IR(KBr) 1605, 1525, 1490, 1417, 1242, 1199, 1127, 1006cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 236 
               
               
                   
               
             
            
               
                 I-1194 
                 mp 174–175° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.48(s, 3H), 3.78(s, 3H), 4.41(s, 4H), 5.17(s, 2H), 5.71(s, 1H), 5.88(s, 1H), 6.48(s, 1H), 6.94–7.50(m, 
               
               
                   
                 18H), 7.86(ABq, J=8.4Hz, 4H) 
               
               
                   
                 IR(KBr) 3463, 3409, 1588, 1519, 1482, 15455, 1417, 1385, 1321, 1285, 1247, 1154, 1112, 1096, 1067, 1015cm −1   
               
               
                 I-1195 
                 mp 165–167° C 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.68(s, 3H), 3.14(s, 3H), 3.56(s, 3H), 3.81(s, 3H), 4.40(s, 4H), 5.20(s, 2H), 6.86(s, 1H), 7.09–7.50(m, 
               
               
                   
                 18H), 7.79(ABq, J=8.1Hz, 4H) 
               
               
                   
                 IR(KBr) 3434, 2938, 1606, 1596, 1518, 1478, 1455, 1368, 1335, 1293, 1268, 1239, 1174, 1157, 1118, 1079cm −1   
               
               
                 I-1196 
                 mp 176–178° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.58(s, 3H), 1.66(s, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.24(s, 3H), 3.55(s, 3H), 3.64(m, 2H), 
               
               
                   
                 3.80(s, 3H), 4.28(t, J=6.0Hz, 1H), 4.64(d, J=6.9Hz, 2H), 5.10(m, 1H), 5.49(m, 1H), 6.86(s, 1H), 7.10(d, J=8.4Hz, 
               
               
                   
                 1H), 7.35(dd, J=2.1, 8.4Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.87(ABq, J=8.7Hz, 4H) 
               
               
                   
                 IR(KBr) 3434, 3321, 2939, 1517, 1477, 1366, 1325, 1292, 1269, 1240, 1176, 1156, 1120, 1077cm −1   
               
               
                 I-1197 
                 mp 180–181° C. 
               
               
                   
                   1 H NMR(DMSO) δ 1.74(s, 3H), 1.77(s, 3H), 2.87(s, 3H), 3.36(s, 3H), 3.51(s, 3H), 3.79(s, 3H), 4.68(d, J=6.6Hz, 2H), 
               
               
                   
                 5.48(m, 1H), 7.10(s, 1H), 7.28–7.30(m, 3H), 7.45(bs, 2H), 7.87(ABq, J=8.7Hz, 4H) 
               
               
                   
                 IR(KBr) 3340, 3238, 2939, 1598, 1518, 1481, 1362, 1333, 1291, 1270, 1239, 1172, 1161, 1120, 1076, 1007cm −1   
               
               
                 I-1198 
                 oil 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.45(s, 3H), 1.66(s, 3H), 1.87(s, 3H), 2.24(s, 3H), 2.27(s, 3H), 2.30(s, 3H), 3.84(s, 3H), 3.92(s, 3H), 
               
               
                   
                 3.95–4.03(m, 1H), 4.50–4.58(m, 1H), 5.22–5.29(m, 1H), 6.87–6.99(m, 4H), 7.09–7.17(m, 3H), 7.80(s, 1H), 8.34–8.42(m, 1H) 
               
               
                   
                 IR(CHCl 3 ) 3673, 3021, 1685, 1639, 1525, 1495, 1406, 1237, 1128, 1037cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 237 
               
               
                   
               
             
            
               
                 I-1199 
                 mp 177–179° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.45(s, 6H), 1.66(s, 6H), 1.87(s, 6H), 2.29(s, 6H), 3.85(s, 6H), 3.95–4.04(m, 2H), 4.50–4.59(m, 2H), 
               
               
                   
                 5.23–5.29(m, 2H), 6.90–6.95(m, 4H), 7.10–7.15(m, 2H), 7.19(s, 2H) 
               
               
                   
                 IR(KBr) 2929, 1661, 1492, 1405, 1288, 1214, 1030, 869, 829cm −1   
               
               
                 I-1200 
                 mp 224–226° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.88(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 6.43(s, 1H), 6.85(s, 1H), 7.01(d, J=8.4Hz, 1H), 
               
               
                   
                 7.20(dd, J=2.1, 8.4Hz, 1H), 7.35–7.42(m, 2H), 7.65–7.72(m, 2H), 7.96(d, J=2.1Hz, 1H), 8.96(s, 1H) 
               
               
                   
                 IR(KBr) 3441, 3370, 3024, 2938, 1729, 1508, 1481, 1365, 1177, 1148, 1085, 884, 798, 524cm −1   
               
               
                 I-1201 
                 powder 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.80(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.79(s, 3H), 4.67(d, J=6.6Hz, 2H), 
               
               
                   
                 5.46–5.51(m, 1H), 6.84(s, 1H), 7.05(d, J=8.1Hz, 1H), 7.22–7.26(m, 1H), 7.36–7.41(m, 2H), 7.67–7.71(m, 2H), 8.35(d, J=1.8Hz, 
               
               
                   
                 1H), 9.24(s, 1H) 
               
               
                   
                 IR(KBr) 3385, 2937, 1718, 1532, 1479, 1362, 1175, 1152, 1078, 973, 876, 797, 526cm −1   
               
               
                 I-1202 
                 mp 260–262° C. 
               
               
                   
                   1 H NMR(DMSO) δ 2.27(s, 6H), 3.87(s, 6H), 7.00(dd, J=1.8, 8.1Hz, 2H), 7.10(d, J=1.8Hz, 2H), 7.21(s, 2H), 7.48(d, J=8.1Hz, 
               
               
                   
                 2H), 10.73(s, 2H) 
               
               
                   
                 IR(KBr) 3392, 3008, 1719, 1600, 1542, 1413, 1297, 1158, 1032, 905, 627cm −1   
               
               
                 I-1203 
                 mp 143–144° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 3.61(s, 3H), 3.67(s, 3H), 3.73(s, 3H), 3.87(s, 3H), 4.62(d, J=6.9Hz, 2H), 
               
               
                   
                 5.50–5.58(m, 1H), 5.66(s, 1H), 6.86–7.02(m, 5H), 7.54(d, J=9Hz, 2H) 
               
               
                   
                 IR(KBr) 3494, 2935, 1673, 1609, 1584, 1519, 1479, 1456, 1389, 1284, 1249, 1178, 1109, 1081, 1016, 829, 798cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 238 
               
               
                   
               
             
            
               
                 I-124 
                 mp 90–91° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.72(s, 3H), 1.79(s, 3H), 2.26(s, 6H), 4.69(d, J=7.2Hz, 2H), 4.9–5.0(brs, 1H), 5.57(t, J=7.2Hz, 
               
               
                   
                 1H), 6.85–7.0(m, 4H), 7.10(d, J=8.7Hz, 2H), 7.23(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3253, 3013, 2979, 2928, 1676, 1584, 1521, 1492, 1232, 1034, 950, 848, 825cm −1   
               
               
                 I-1205 
                 mp 131–132° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.73(s, 3H), 1.79(s, 3H), 3.43(s, 3H), 3.76(s, 3H), 4.68(d, J=6.9Hz, 2H), 4.9–5.1(brs, 1H), 5.58(t, J=7.2Hz, 
               
               
                   
                 1H), 6.09(brs, 1H), 6.44(s, 1H), 6.92(d, J=8.4Hz, 2H), 7.0–7.1(m, 2H), 7.52(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 3428, 2951, 2932, 1671, 1611, 1523, 1491, 1402, 1233, 1111, 1077, 1027, 969, 833cm −1   
               
               
                 I-1206 
                 mp 191–192° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.15(s, 6H), 3.22(s, 3H), 3.87(s, 3H), 5.18(AB q, J=12.0Hz, 2H), 6.74(dd, J=2.1, 8.1Hz, 1H), 6.78 
               
               
                   
                 (d, J=2.1Hz, 1H), 6.93(d, J=8.1Hz, 1H), 7.24(s, 1H), 7.30–7.50(m, 9H) 
               
               
                   
                 IR(KBr) 1528, 1479, 1453, 1364, 1326, 1262, 1243, 1223, 1209, 1200, 1176, 1152, 1137, 963, 870, 846, 754cm −1   
               
               
                 I-1207 
                 mp 108–109° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(d, J=0.6Hz, 3H), 2.27(s, 3H), 2.28(s, 3H), 4.56(d, J=6.6Hz, 2H), 4.89(s, 1H), 
               
               
                   
                 5.54(m, 1H), 6.86–6.92(m, 2H), 6.94–7.00(m, 2H), 7.12(s, 1H), 7.13(s, 1H), 7.22–7.27(m, 2H), 7.27–7.31(m, 2H) 
               
               
                   
                 IR(KBr) 3349, 1608, 1520, 1488, 1439, 1383, 1287, 1263, 1235, 1175, 999, 979cm −1   
               
               
                 I-1208 
                 mp 194–195° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.14(s, 3H), 2.16(s, 3H), 3.87(s, 3H), 4.97(s, 1H), 5.17(AB q, J=12.6Hz, 2H), 6.74(dd, J=2.1, 8.1Hz, 
               
               
                   
                 1H), 6.79(d, J=2.1Hz, 1H), 6.88–6.93(m, 2H), 6.93(d, J=8.1Hz, 1H), 7.17–7.22(m, 2H), 7.24(s, 1H), 7.29–7.49(m, 
               
               
                   
                 5H) 
               
               
                   
                 IR(KBr) 3408, 1611, 1526, 1479, 1463, 1455, 1382, 1263, 1242, 1225, 1212, 1143, 997, 751cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 239 
               
               
                   
               
             
            
               
                 I-1209 
                 mp 183–184° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.03(s, 3H), 2.07(s, 3H), 3.19(s, 3H), 3.80(br s, 2H), 3.89(s, 3H), 5.21(s, 2H), 6.63(s, 1H), 6.77(dd, J=2.1, 
               
               
                   
                 8.1Hz, 1H), 6.83(d, J=2.1Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.29–7.52(m, 9H) 
               
               
                   
                 IR(KBr) 3481, 3391, 1610, 1511, 1482, 1370, 1240, 1212, 1197, 1173, 1153, 1137, 1024, 1007, 870, 844cm −1   
               
               
                 I-1210 
                 mp 133–134° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.80(s, 3H), 2.16(s, 3H), 2.17(s, 3H), 3.22(s, 3H), 3.85(s, 3H), 4.61(d, J=6.9Hz, 2H), 
               
               
                   
                 5.55(m, 1H), 6.74–6.79(m, 2H), 6.92(d, J=8.7Hz, 1H), 7.24(s, 1H), 7.39(s, 4H) 
               
               
                   
                 IR(KBr) 1529, 1516, 1478, 1371, 1353, 1328, 1263, 1242, 1201, 1176, 1150, 975, 866, 846, 787cm −1   
               
               
                 I-1211 
                 mp 243–244° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.91(s, 3H), 1.96(s, 3H), 3.77(s, 3H), 4.05(br s, 2H), 5.12(s, 2H), 6.40(s, 1H), 6.71(dd, J=1.8, 8.1Hz, 
               
               
                   
                 1H), 6.77–6.84(m, 3H), 7.06–7.12(m, 2H), 7.16(d, J=8.1Hz, 1H), 7.32–7.52(m, 5H), 9.38(s, 1H) 
               
               
                   
                 IR(KBr) 3378, 3289, 1609, 1586, 1518, 1483, 1454, 1402, 1267, 1236, 1207, 1171, 1136, 1024, 853, 835, 816, 753, 730, 695cm −1   
               
               
                 I-1212 
                 mp 195–196° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.79(s, 3H), 2.15(s, 3H), 2.16(s, 3H), 3.85(s, 3H), 4.61(d, J=6.9Hz, 2H), 4.97(s, 1H), 
               
               
                   
                 5.55(m, 1H), 6.76–6.79(m, 2H), 6.89–6.94(m, 3H), 7.18–7.23(m, 2H), 7.24(s, 1H) 
               
               
                   
                 IR(KBr) 3462, 1611, 1519, 1479, 1459, 1431, 1379, 1271, 1240, 1228, 1211, 1137, 983, 835cm −1   
               
               
                 I-1213 
                 IR(KBr) 3275, 1494, 1462, 1444, 1387, 1371, 1232, 1212, 1183, 1141cm −1   
               
               
                 I-124 
                 mp 106–108° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.24(s, 3H), 3.79(s, 3H), 4.72(br, 1H), 5.20(s, 2H), 6.72–7.18(m, 8H), 7.36–7.50(m, 6H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 1610, 1523, 1493, 1465, 1455, 1388, 1318, 1298, 1262, 1173, 1127, 1038, 834cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 240 
               
               
                   
               
             
            
               
                 I-1215 
                 mp 108–110° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.25(s, 3H), 3.79(s, 3H), 4.63–4.65(d, J=7.2Hz, 2H), 5.56(s, 2H), 6.81(s, 
               
               
                   
                 1H), 6.87–7.18(m, 6H), 7.44–7.47(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 2937, 1610, 1523, 1493, 1465, 1446, 1387, 1297, 1261, 1173, 1125, 1038, 993, 834cm −1   
               
               
                 I-1216 
                 mp 121–122° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.24(s, 3H), 3.79(s, 3H), 4.78–4.80(d, J=6.9Hz, 2H), 6.24(t, J=6.9Hz, 1H), 6.80(s, 1H), 6.87–7.19 
               
               
                   
                 (m, 6H), 7.43–7.48(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 1612, 1523, 1493, 1464, 1389, 1300, 1259, 1173, 1127, 1038, 886, 834cm −1   
               
               
                 I-1217 
                 mp 163–165° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.26(s, 3H), 2.28(s, 3H), 4.78(br s, 1H), 4.78(d, J=6.5Hz, 2H), 5.60(s, 1H) 6.23(t, J=6.5Hz, 1H), 
               
               
                   
                 6.83–6.92(m, 4H), 6.99(d, J=2.1Hz, 1H), 7.10(s, 1H), 7.11(s, 1H), 7.22–7.27(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3597, 3548, 3027, 3010, 1613, 1588, 1522, 1490, 1218, 1208, 1171cm −1   
               
               
                 I-1218 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.37(s, 3H), 3.39(s, 3H), 3.73(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 5.92(s, 1H), 6.46(s, 1H), 6.71(dd, J=3.7, 
               
               
                   
                 0.7Hz, 1H), 6.96(dd, J=8.4, 2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.26(dd, J=8.6, 0.7Hz, 
               
               
                   
                 2H), 7.37–7.45(m, 5H), 7.60(dd, J=8.7, 1.5Hz, 1H), 7.61(d, J=3.7Hz, 1H), 7.78(d, J=1.5Hz, 1H), 7.82(d, J=8.6Hz, 
               
               
                   
                 1H), 8.05(d, J=8.7Hz, 1H) 
               
               
                   
                 IR(KBr) 3476, 1457, 1371, 1254, 1107, 1131, 1107, 1011, 814, 685, 581cm −1   
               
               
                 I-1219 
                 mp 217–219° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.37(s, 3H), 2.69(s, 3H), 3.12(s, 3H), 3.47(s, 3H), 3.76(s, 3H), 5.18(s, 2H), 6.71(d, J=3.8Hz, 1H), 
               
               
                   
                 6.86(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.26(d, J=8.7Hz, 2H), 7.32–7.48(m, 7H), 7.56(dd, J=8.7, 1.8Hz, 1H), 7.61(d, J=3.8Hz, 
               
               
                   
                 1H), 7.78(d, J=1.8Hz, 1H), 7.82(d, J=8.7Hz, 1H), 8.05(d, J=8.7Hz, 1H) 
               
               
                   
                 IR(KBr) 1366, 1174, 1079, 963, 814, 685, 586cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 241 
               
               
                   
               
             
            
               
                 I-1220 
                 mp 208–210° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.37(s, 3H), 2.72(s, 3H), 3.23(s, 3H), 3.47(s, 3H), 3.76(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.49(t, J=6.6Hz, 
               
               
                   
                 1H), 6.71(d, J=3.8Hz, 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.26(d, J=8.3Hz, 2H), 7.35(dd, J=8.4, 2.1Hz, 1H), 
               
               
                   
                 7.40(d, J=2.1Hz, 1H), 7.56(dd, J=8.4, 1.7Hz, 1H), 7.61(d, J=3.8Hz, 1H), 7.78(d, J=1.7Hz, 1H), 7.82(d, J=8.3Hz, 
               
               
                   
                 2H), 8.05(d, J=8.7Hz, 1H) 
               
               
                   
                 IR(KBr) 1466, 1445, 1365, 1174, 1116, 1079, 964, 812, 686, 584cm −1   
               
               
                 I-1221 
                 mp 203–205° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.39(s, 3H), 2.69(s, 3H), 2.97(t, J=8.6Hz, 2H), 3.23(s, 3H), 3.50(s, 3H), 
               
               
                   
                 3.77(s, 3H), 3.98(t, J=8.6Hz, 2H), 4.63(d, J=6.6Hz, 2H), 5.49(t, J=6.6Hz, 1H), 6.80(s, 1H), 7.08(d, J=8.5Hz, 1H), 
               
               
                   
                 7.24–7.28(m, 2H), 7.33(dd, J=8.5, 2.0Hz, 1H), 7.37–7.39(m, 2H), 7.41–7.45(m, 1H), 7.71(d, J=8.4Hz, 1H), 7.73(d, J=8.1Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 1474, 1362, 1241, 1166, 1079, 975, 808cm −1   
               
               
                 I-1222 
                 amorphous 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.82(s, 3H), 2.39(s, 3H), 2.98(t, J=8.4Hz, 2H), 3.43(s, 3H), 3.73(s, 3H), 3.98(t, J=8.4Hz, 
               
               
                   
                 2H), 4.61(d, J=6.6Hz, 2H), 5.53(t, J=6.6Hz, 1H), 5.68(s, 1H), 5.86(s, 1H), 6.40(s, 1H), 6.93–6.95(m, 2H), 7.03–7.05 
               
               
                   
                 (m, 1H), 7.23–7.27(m, 2H), 7.35–7.37(m, 1H), 7.45–7.50(m, 1H), 7.71(d, J=8.4Hz, 1H), 7.74(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 3457, 1480, 1354, 1244, 1164, 1099, 978, 817cm −1   
               
               
                 I-1223 
                 mp 199–201° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.19(s, 3H), 3.72(s, 3H), 3.90(s, 3H), 4.20–4.27(m, 4H), 5.20(s, 2H), 6.53(s, 1H), 6.90–6.99(m, 3H), 
               
               
                   
                 7.25–7.65(m, 9H) 
               
               
                   
                 IR(KBr) 3434, 2938, 1604, 1586, 1522, 1484, 1465, 1432, 1368, 1339, 1326, 1249, 1226, 1203, 1174, 1146, 1136, 1106, 
               
               
                   
                 1027cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 242 
               
               
                   
               
             
            
               
                 I-1224 
                 mp 127–129° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.57(s, 3H), 1.65(s, 3H), 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.64(m, 2H), 3.76(s, 3H), 4.30(t, J=5.7Hz, 
               
               
                   
                 1H), 4.62(d, J=6.9Hz, 2H), 5.10(m, 1H), 5.53(m, 1H), 5.72(s, 1H), 5.85(s, 1H), 6.47(s, 1H), 6.93(dd, J=1.8, 8.4Hz, 
               
               
                   
                 1H), 6.98(d, J=8.4Hz, 1H), 7.05(d, J=1.8Hz, 1H), 7.88(ABq, J=8.7Hz, 4H) 
               
               
                   
                 IR(KBr) 3478, 3314, 2937, 1585, 1556, 1518, 1501, 1484, 1460, 1417, 1387, 1363, 1328, 1279, 1243, 1228, 1191, 1155, 
               
               
                   
                 1129, 1113, 1090, 1068, 1013cm −1   
               
               
                 I-1225 
                 mp 162–164° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.19(s, 3H), 3.72(s, 3H), 4.19–4.23(m, 4H), 5.18(s, 2H), 6.52(s, 1H), 7.03–7.64(m, 12H) 
               
               
                   
                 IR(KBr) 3433, 2933, 1523, 1483, 1463, 1435, 1377, 1360, 1269, 1227, 1172, 1149, 1126, 1096cm −1   
               
               
                 I-1226 
                 mp 188–190° C. 
               
               
                   
                   1 H NMR(DMSO) δ 1.72(s, 3H), 1.75(s, 3H), 3.33(s, 3H), 3.67(s, 3H), 4.55(d, J=6.9Hz, 2H), 5.49(m, 1H), 6.50(s, 1H), 
               
               
                   
                 6.66(dd, J=2.1, 8.1Hz, 1H), 6.74(d, J=2.1Hz, 1H), 6.91(d, J=8.1Hz, 1H), 7.42(bs, 2H), 7.85(ABq, J=8.4Hz, 4H), 8.75 
               
               
                   
                 (bs, 2H) 
               
               
                   
                 IR(KBr) 3465, 2937, 1588, 1517, 1500, 1483, 1470, 1446, 1415, 1385, 1340, 1308, 1283, 1246, 1224, 1201, 1186, 1168, 
               
               
                   
                 1130, 1116, 1091, 1067, 1011cm −1   
               
               
                 I-1227 
                 mp 172–174° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.78(s, 3H), 3.19(s, 3H), 3.72(s, 3H), 3.87(s, 3H), 4.20–4.27(m, 4H), 4.62(d, J=6.9Hz, 
               
               
                   
                 2H), 5.57(m, 1H), 6.54(s, 1H), 6.96(s, 3H), 7.49(ABq, J=8.7Hz, 4H) 
               
               
                   
                 IR(KBr) 3433, 2937, 1604, 1582, 1522, 1483, 1465, 1432, 1368, 1340, 1326, 1242, 1226, 1218, 1204 1174, 1138, 1107cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 243 
               
               
                   
               
             
            
               
                 I-1228 
                 mp 169–175° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ −0.07–0.02(m, 2H), 0.34–0.42(m, 2H), 0.98(m, 1H), 2.44(s, 3H), 3.20(s, 3H), 3.47(d, J=7.2Hz, 2H), 
               
               
                   
                 3.78(s, 3H), 3.91(s, 3H), 5.22(s, 2H), 6.85(s, 1H), 6.91(dd, J=1.8, 8.1Hz, 1H), 6.976(d, J=1.8Hz, 1H), 6.979(d, J=8.1Hz, 
               
               
                   
                 1H), 7.26–7.73(m, 9H) 
               
               
                   
                 IR(KBr) 3447, 2934, 1604, 1518, 1480, 1390, 1362, 1240, 1227, 1175, 1140, 1081cm −1   
               
               
                 I-1229 
                 mp 172–174° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.74(s, 3H), 1.78(s, 3H), 3.71(s, 3H), 3.87(s, 3H), 4.20–4.25(m, 4H), 4.62(d, J=6.3Hz, 2H), 4.94(bs, 
               
               
                   
                 1H), 5.57(m, 1H), 6.55(s, 1H), 6.89–7.50(m, 7H) 
               
               
                   
                 IR(KBr) 3410, 2933, 1611, 1522, 1484, 1462, 1422, 1371, 1264, 1238, 1224, 1173, 1134, 1103cm −1   
               
               
                 I-1230 
                 mp 149–151° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.81(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 3.87(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.54–5.58(m, 
               
               
                   
                 1H), 5.69(s, 1H), 5.91(s, 1H), 6.46(s, 1H), 6.93–7.06(m, 5H), 7.58(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3501, 2939, 1680, 1609, 1582, 1520, 1487, 1458, 1397, 1284, 1246, 1191, 1179, 1115, 1067, 1015, 940, 822, 794cm −1   
               
               
                 I-1231 
                 mp 151–152° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(d, J=0.6Hz, 3H), 1.81(d, J=0.6Hz, 3H), 2.04(s, 3H), 2.08(s, 3H), 3.20(s, 3H), 3.77(br s, 2H), 
               
               
                   
                 3.86(s, 3H), 4.65(d, J=6.6Hz, 2H), 5.58(m, 1H), 6.04(s, 1H), 6.81(dd, J=2.1, 8.7Hz, 1H), 6.81(d, J=2.1Hz, 1H), 7.01 
               
               
                   
                 (d, J=8.7Hz, 1H), 7.30–7.36(m, 2H), 7.38–7.43(m, 2H) 
               
               
                   
                 IR(KBr) 3484, 3393, 2934, 1608, 1511, 1482, 1371, 1239, 1213, 1197, 1173, 1153, 1138, 989, 973, 871, 844, 791cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 244  
               
               
                   
               
             
            
               
                 I-1232 
                 mp 198–199° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.72(s, 3H), 1.77(s, 3H), 1.91(s, 3H), 1.95(s, 3H), 3.75(s, 3H), 4.04(s, 2H), 4.55(d, J=6.9Hz, 
               
               
                   
                 2H), 5.48(m, 1H), 6.40(s, 1H), 6.69(dd, J=1.8, 8.1Hz, 1H), 6.75(d, J=1.8Hz, 1H), 6.77–6.83(m, 2H), 7.05–7.11(m, 3H), 
               
               
                   
                 9.39(s, 1H) 
               
               
                   
                 IR(KBr) 3375, 3287, 2913, 1609, 1587, 1578, 1518, 1484, 1434, 1403, 1270, 1235, 1207, 1171, 1136, 1032, 1009, 863, 853, 
               
               
                   
                 816, 749cm −1   
               
               
                 I-1233 
                 mp 198–199° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.80(s, 3H), 1.91(s, 3H), 2.11(s, 3H), 2.13(s, 3H), 3.20(s, 3H), 3.84(s, 3H), 4.64(d, J=6.6Hz, 
               
               
                   
                 2H), 5.58(m, 1H), 6.46(s, 1H), 6.69–6.74(m, 2H), 6.96(d, J=8.4Hz, 1H), 7.11(s, 1H), 7.32–7.38(m, 2H), 7.40–7.46 
               
               
                   
                 (m, 2H) 
               
               
                   
                 IR(KBr) 1651, 1513, 1470, 1448, 1414, 1368, 1330, 1267, 1241, 1214, 1199, 1175, 970, 869cm −1   
               
               
                 I-1232 
                 mp 193–194° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.80(d, J=0.6Hz, 3H), 1.94(s, 3H), 2.11(s, 3H), 2.13(s, 3H), 3.84(s, 3H), 4.64(d, J=6.6Hz, 
               
               
                   
                 2H), 5.58(m, 1H), 6.58(s, 1H), 6.70–6.75(m, 2H), 6.85–6.93(m, 2H), 6.96(d, J=8.4Hz, 1H), 7.13(s, 1H), 7.19–7.24(m, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3271, 1654, 1611, 1517, 1467, 1448, 1370, 1289, 1262, 1240, 1213, 1177, 1136, 835cm −1   
               
               
                 I-1235 
                 mp 114–115° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.27(s, 6H), 3.91(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.56(m, 1H), 5.61(s, 1H), 
               
               
                   
                 6.86(dd, J=2.1, 8.4Hz, 1H), 6.86(d, J=2.1Hz, 1H), 6.97(d, J=8.4Hz, 1H), 7.02–7.14(m, 5H) 
               
               
                   
                 IR(KBr) 3410, 1597, 1521, 1470, 1449, 1415, 1382, 1297, 1276, 1261, 1220, 1122, 1052, 983, 862cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 245 
               
               
                   
               
             
            
               
                 I-1236 
                 powder 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.22(s, 3H), 3.38(s, 3H), 3.46(s, 3H), 3.92(s, 3H), 5.22(s, 2H), 5.76(s, 1H), 6.97–7.09(m, 3H), 7.32–7.51 
               
               
                   
                 (m, 9H) 
               
               
                   
                 IR(KBr) 3448, 2935, 1516, 1455, 1394, 1366, 1352, 1246, 1148, 1076, 1015, 972, 881, 699, 541, 524cm −1   
               
               
                 I-1237 
                 mp 169–172° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.49(s, 3H), 3.21(s, 3H), 3.47(s, 3H), 3.50(s, 3H), 3.92(s, 3H), 5.23(s, 2H), 6.95–7.04(m, 3H), 7.31–7.49 
               
               
                   
                 (m, 9H) 
               
               
                   
                 IR(KBr) 3009, 2932, 1518, 1459, 1370, 1362, 1250, 1176, 1151, 872, 809, 542, 527cm −1   
               
               
                 I-1238 
                 mp 182–184° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.67(s, 3H), 3.21(s, 3H), 3.48(s, 3H), 3.50(s, 3H), 3.93(s, 3H), 5.77(s, 1H), 6.98–7.06(m, 3H), 7.38–7.51 
               
               
                   
                 (m, 4H) 
               
               
                   
                 IR(KBr) 3548, 3502, 2938, 1602, 1519, 1389, 1364, 1176, 1159, 1012, 963, 875, 521cm −1   
               
               
                 I-1239 
                 mp 132–135° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.80(s, 3H), 2.62(s, 3H), 3.21(s, 3H), 3.48(s, 3H), 3.51(s, 3H), 3.90(s, 3H), 4.64(d, J=6.6Hz, 2H), 
               
               
                   
                 5.51–5.58(m, 1H), 6.97–7.04(m, 3H), 7.37–7.51(m, 4H) 
               
               
                   
                 IR(KBr) 2936, 1518, 1464, 1375, 1362, 1246, 1175, 1153, 1013, 968, 872, 805, 529cm −1   
               
               
                 I-1240 
                 mp 169–172° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(s, 3H), 3.38(s, 3H), 3.47(s, 3H), 3.89(s, 3H), 4.65(d, J=6.6Hz, 2H), 5.06(s, 1H), 
               
               
                   
                 5.54–5.61(m, 1H), 5.83(s, 1H), 6.92–7.00(m, 3H), 7.05–7.09(m, 2H), 7.28–7.33(m, 2H) 
               
               
                   
                 IR(KBr) 3458, 2935, 1611, 1520, 1458, 1392, 1244, 1222, 1015, 828, 803cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 246 
               
               
                   
               
             
            
               
                 I-1241 
                 mp 170–173° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.73(s, 3H), 1.79(s, 3H), 2.55–3.00(m, 3H), 3.21(s, 3H), 3.22–3.80(m, 6H), 4.55–4.63(m, 2H), 5.41–5.47 
               
               
                   
                 (m, 1H), 6.83(s, 1H), 7.03–7.70(m, 8H) 
               
               
                   
                 IR(KBr) 2938, 1686, 1516, 1481, 1378, 1235, 1235, 1179, 1152, 1081, 847, 799, 675, 527cm −1   
               
               
                 I-1242 
                 mp 117–118° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H) 1.81(d, J=0.6Hz, 3H), 2.11(s, 3H), 2.19(s, 3H), 3.38(s, 3H), 4.64(d, J=6.9Hz, 2H), 4.75 
               
               
                   
                 (br s, 1H), 5.54–5.90(m, 1H), 6.86–6.91(m, 2H), 6.93(s, 1H), 7.10–7.69(m, 3H), 7.20–7.25(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 3010, 2934, 1675, 1519, 1473, 1262, 1172, 1098cm −1   
               
               
                 I-1243 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.43(s, 3H), 3.72(s, 3H), 5.03(s, 2H), 6.43(s, 1H), 6.93(dd, J=8.4, 2.1Hz, 1H), 6.94(d, J=8.7Hz, 
               
               
                   
                 2H), 7.09(d, J=2.1Hz, 1H), 7.11(d, J=8.4Hz, 1H), 7.29(ddd, J=7.8, 4.8, 1.5Hz, 1H), 7.49(brd, J=7.8Hz, 1H), 7.53(d, 
               
               
                   
                 J=8.7Hz, 2H), 7.70(ddd, J=7.8, 7.8, 1.5Hz, 1H), 8.61(brd, J=4.8Hz, 1H) 
               
               
                   
                 IR(KBr) 3432, 1611, 1588, 1562, 1523, 1488, 1467, 1226, 1114, 1071, 1015, 939, 824, 778, 758cm −1   
               
               
                 I-1244 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 5.01(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.99(dd, J=8.4, 2.1Hz, 
               
               
                   
                 1H), 7.10(d, J=2.1Hz, 1H), 7.14(d, J=8.4Hz, 1H), 7.30–7.36(m, 3H), 7.46–7.49(m, 2H), 7.54(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3433, 1612, 1589, 1523, 1489, 1403, 1224, 1192, 1113, 1070, 1013, 938, 813, 758cm −1   
               
               
                 I-1245 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 5.01(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.99(dd, J=5.1, 3.6Hz, 
               
               
                   
                 1H), 6.99(dd, J=8.4, 2.1Hz, 1H), 7.10(d, J=2.1Hz, 1H), 7.11(d, J=8.4Hz, 1H), 7.27(dd, J=3.6, 1.0Hz, 1H), 7.29(dd, J=5.1, 
               
               
                   
                 1.0Hz, 1H), 7.54(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3433, 1612, 1589, 1523, 1488, 1403, 1241, 1224, 1192, 1113, 1070, 1011, 826cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 247 
               
               
                   
               
             
            
               
                 I-1246 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 4.93(s, 2H), 5.70(d, J=1.5Hz, 1H), 5.75(d, J=1.5Hz, 1H), 6.45(s, 1H), 
               
               
                   
                 6.92(d, J=8.7Hz, 2H), 6.99(dd, J=8.4, 2.1Hz, 1H), 7.05(d, J=8.4Hz, 1H), 7.10(d, J=2.1Hz, 1H), 7.54(d, J=8.7Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3432, 1611, 1590, 1523, 1489, 1403, 1224, 1193, 1113, 1071, 1010, 938, 826cm −1   
               
               
                 I-1247 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 5.53(d, J=10.5Hz, 1H), 5.69(d, J=16.5Hz, 1H), 6.11(ddd, J=16.5, 10.5, 
               
               
                   
                 6.3Hz, 1H), 6.44(d, J=6.3Hz, 1H), 6.45(s, 1H), 6.88(d, J=8.4Hz, 1H), 6.91–6.93(m, 2H), 6.92(d, J=8.7Hz, 2H), 
               
               
                   
                 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3433, 1611, 1592, 1522, 1485, 1403, 1226, 1106, 1059, 814cm −1   
               
               
                 I-1248 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.16(t, J=7.5Hz, 3H), 2.26(tq, J=2.1, 7.5Hz, 2H), 3.45(s, 3H), 3.75(s, 3H), 4.76(t, J=2.1Hz, 2H), 
               
               
                   
                 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.96(dd, J=2.1, 8.4Hz, 1H), 7.06(d, J=8.4Hz, 1H), 7.07(d, J=2.1Hz, 1H), 7.53(d, 
               
               
                   
                 J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3434, 2230, 1612, 1590, 1523, 1479, 1225, 1113, 1070, 1005, 938, 815cm −1   
               
               
                 I-1249 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.38(s, 3H), 3.67(s, 3H), 5.12(s, 2H), 6.43(s, 1H), 6.56(d, J=3.3Hz, 1H), 6.79(dd, J=2.1, 8.1Hz, 
               
               
                   
                 1H), 6.84(d, J=8.7Hz, 2H), 6.87(d, J=2.1Hz, 1H), 7.02(d, J=3.3Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.45(d, J=8.7Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3431, 1698, 1611, 1523, 1489, 1405, 1246, 1114, 1071, 1012, 816, 786cm −1   
               
               
                 I-1250 
                   1 H NMR(CDCl 3 ) δ 3.38(s, 3H), 3.67(s, 3H), 4.66(tt, J=2.7, 6.9Hz, 2H), 4.90(tt, J=2.7, 6.9Hz, 2H), 5.43(tt, J=6.9, 
               
               
                   
                 6.9Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(br.s, 2H), 7.07(s, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3430, 1955, 1612, 1589, 1522, 1489, 1404, 1248, 1113, 1070, 1008, 938, 845, 825cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 248 
               
               
                   
               
             
            
               
                 I-1251 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.69(dd, J=3.3, 6.9Hz, 3H), 3.46(s, 3H), 3.74(s, 3H), 4.63(dd, J=2.4, 6.3Hz, 2H), 5.28(m, 1H), 
               
               
                   
                 5.33(m, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(d, J=1.5Hz, 1H), 6.96(br.s, 1H), 7.06(d, J=1.5Hz, 1H), 7.52(d, J=8.7Hz, 
               
               
                   
                 2H) 
               
               
                   
                 IR(KBr) 3436, 2933, 1968, 1612, 1587, 1523, 1489, 1464, 1404, 1112, 1071, 1011, 998, 824cm −1   
               
               
                 I-1252 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.02(t, J=7.2Hz, 3H), 2.05(ddq, J=3.3, 6.3, 7.2Hz, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.64(dd, J=2.4, 
               
               
                   
                 6.0Hz, 2H), 5.40(m, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.94(d, J=2.1, 8.4Hz, 1H), 6.97(d, J=8.4Hz, 1H), 7.06(d, 
               
               
                   
                 J=2.1Hz, 1H), 7.54(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3479, 2960, 2933, 1964, 1612, 1582, 1522, 1489, 1403, 1242, 1113, 1072, 1011, 999, 944, 872cm −1   
               
               
                 I-1253 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.03(d, J=6.6Hz, 6H), 2.34(m, 1H), 3.46(s, 3H), 3.74(s, 3H), 4.63(dd, J=2.7, 6.3Hz, 2H), 5.33(m, 
               
               
                   
                 1H), 5.44(m, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.93(d, J=1.8, 7.8Hz, 1H), 6.97(d, J=7.8Hz, 1H), 7.06(d, J=1.8Hz, 
               
               
                   
                 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3434, 2958, 1960, 1612, 1589, 1523, 1489, 1226, 1113, 1071, 1011, 939, 825cm −1   
               
               
                 I-124 
                 foam 
               
               
                   
                   1  H NMR(CDCl 3 ) δ 2.62(d, J=2.4Hz, 1H), 3.45(s, 3H), 3.75(s, 3H), 4.18(dd, J=7.2, 11.4Hz, 1H), 4.38(dd, J=2.4, 11.4Hz, 
               
               
                   
                 1H), 4.94(ddd, J=2.4, 2.4, 7.2Hz, 1H), 6.44(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.98(d, J=8.4Hz, 1H), 7.01(d, J=1.8, 
               
               
                   
                 8.4Hz, 1H), 7.08(d, J=1.8Hz, 1H), 7.52(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3434, 3283, 2127, 1612, 1586, 15323, 1487, 1226, 1115, 1069, 1007, 943, 825cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 249 
               
               
                   
               
             
            
               
                 I-1255 
                 mp 148–150° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.99(s, 6H), 3.75–3.80(br, 2H), 3.75(s, 3H), 3.77(s, 3H), 6.45–6.53(m, 2H), 6.79–6.83(m, 2H), 6.88(s, 
               
               
                   
                 1H), 6.95(s, 1H), 7.17–7.23(m, 1H), 7.48–7.51(m, 2H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1630, 1609, 1530, 1492, 1461, 1444, 1388, 1331, 1209, 1165, 1125, 1050, 1028cm −1   
               
               
                 I-1256 
                 mp 209–212° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.00(s, 6H), 3.11(s, 3H), 3.76(s, 3H), 3.79(s, 3H), 6.66(br s, 1H), 6.78–6.83(m, 2H), 6.87(s, 1H), 
               
               
                   
                 6.98(s, 1H), 7.02(dd, J=2.4, 8.4Hz, 1H), 7.10(dd, J=2.4, 10.8Hz, 1H), 7.39–7.52(m, 3H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1627, 1609, 1530, 1494, 1463, 1390, 1325, 1213, 1154, 1127, 1052, 1028, 984cm −1   
               
               
                 I-1257 
                 mp 198–200° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.43(t, J=7.5Hz, 3H), 3.00(s, 3H), 3.19–3.26(m, 2H), 3.76(s, 3H), 3.79(s, 3H), 6.69(br s, 1H), 
               
               
                   
                 6.79–6.85(m, 2H), 6.86(s, 1H), 6.97(s, 1H), 7.01(dd, J=2.4, 8.4Hz, 1H), 7.09(dd, J=2.4, 10.8Hz, 1H), 7.37–7.53(m, 3H) 
               
               
                   
                 IR(KBr) 3600–2800(br), 1611, 1530, 1492, 1495, 1445, 1389, 1355, 1325, 1207, 1163, 1141, 1122, 1051, 1025, 981cm −1   
               
               
                 I-1258 
                 IR(KBr) 1612, 1526, 1490, 1444, 1349, 1301, 1196, 1129, 1038cm −1   
               
               
                   
                 mp 102–103° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.27(s, 3H), 2.31(s, 3H), 3.00(s, 6H), 4.78(d, J=6.6Hz, 2H), 6.24(t, J=6.6Hz, 1H), 6.80(d, J=8.4Hz, 
               
               
                   
                 2H), 6.96–7.16(m, 5H), 7.26(d, J=8.4Hz, 2H) 
               
               
                 I-1259 
                 mp 114–115° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.79(s, 3H), 3.61(s, 3H), 3.65(s, 3H), 3.74(s, 3H), 3.87(s, 3H), 3.88(s, 3H), 4.63(d, J=6.9Hz, 
               
               
                   
                 2H), 5.54–5.62(m, 1H), 6.68(s, 1H), 6.94–7.03(m, 5H), 7.54(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr) 3433, 2932, 1682, 1605, 1580, 1519, 1465, 1439, 1389, 1290, 1253, 1237, 1186, 1140, 1109, 1089, 1039, 1029, 992, 
               
               
                   
                 833cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 250 
               
               
                   
               
             
            
               
                 I-1260 
                 mp 163–165° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 3.19(s, 3H), 3.72(s, 3H), 4.20–4.26(m, 4H), 4.62(d, J=6.6Hz, 2H), 5.55(m, 
               
               
                   
                 1H), 6.53(s, 1H), 7.00–7.20(m, 3H), 7.49(ABq, J=8.1Hz, 4H) 
               
               
                   
                 IR(KBr) 3433, 2933, 1523, 1483, 1463, 1433, 1371, 1359, 1340, 1299, 1266, 1227, 1220, 1172, 1149, 1127, 1098cm −1   
               
               
                 I-1261 
                 mp 135–137° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ −0.03–0.03(m, 2H), 0.36–0.42(m, 2H), 1.00(m, 1H), 1.75(s, 3H), 1.79(s, 3H), 2.56(s, 3H), 3.20(s, 3H), 
               
               
                   
                 3.48(d, J=4.8Hz, 2H), 3.78(s, 3H), 3.88(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.54(m, 1H), 6.86(s, 1H), 6.95–6.97(m, 3H), 7.55 
               
               
                   
                 (ABq, J=8.7Hz, 4H) 
               
               
                   
                 IR(KBr) 3433, 2936, 1604, 1519, 1481, 1467, 1369, 1336, 1245, 1231, 1201, 1177, 1153, 1081cm −1   
               
               
                 I-1262 
                 mp 181–182° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(s, 3H), 3.72(s, 3H), 4.19–4.26(m, 4H), 4.62(d, J=6.9Hz, 2H), 4.91(bs, 1H), 5.55 
               
               
                   
                 (m, 1H), 6.53(s, 1H), 6.89–7.49(m, 7H) 
               
               
                   
                 IR(KBr) 3404, 1612, 1523, 1485, 1462, 1434, 1373, 1266, 1227, 1212, 1116, 1101cm −1   
               
               
                 I-1263 
                 mp 80–82° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ −0.05–0.09(m, 2H), 0.44–0.51(m, 2H), 1.04(m, 1H), 1.74(s, 3H), 1.78(s, 3H), 3.33(d, J=4.8Hz, 2H), 
               
               
                   
                 3.75(s, 3H), 3.88(s, 3H), 4.63(d, J=6.6Hz, 2H), 4.98(s, 1H), 5.57(m, 1H), 6.15(s, 1H), 6.46(s, 1H), 6.89–7.03(m, 5H), 
               
               
                   
                 7.52–7.56(m, 2H) 
               
               
                   
                 IR(KBr) 3374, 1614, 1523, 1490, 1465, 1446, 1391, 1267, 1235, 1172, 1113, 1073cm −1   
               
               
                 I-1264 
                 mp 112–113° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.19(s, 3H), 2.28(s, 3H), 3.91(s, 3H), 5.20(s, 2H), 6.84–6.86(m, 1H), 6.92–6.97(m, 2H), 7.09(s, 1H), 
               
               
                   
                 7.16(s, 1H), 7.31–7.43(m, 5H), 7.47–7.49(m, 2H), 7.60(d, J=10.2Hz, 1H), 8.01(brs, 1H) 
               
               
                   
                 IR(KBr) 3421, 3303, 2935, 1711, 1519, 1490, 1365, 1231, 1198, 1178, 1134, 1009, 864cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 251 
               
               
                   
               
             
            
               
                 I-1265 
                 mp 85–86° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.85(s, 3H), 3.32(s, 3H), 3.82(s, 3H), 3.96(s, 3H), 5.38(s, 2H), 7.04(s, 1H), 7.22(s, 1H), 7.25(d, J=8.4Hz, 
               
               
                   
                 1H), 7.35(d, J=8.4Hz, 1H), 7.48–7.67(m, 7H), 8.45(brs, 1H) 
               
               
                   
                 IR(KBr) 3432, 2938, 1740, 1608, 1517, 1483, 1396, 1366, 1271, 1179, 1111, 1080, 832, 810, 698cm −1   
               
               
                 I-1266 
                 mp 79–80° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.14(s, 3H), 3.50(s, 3H), 4.95(brs, 1H), 5.22(s, 2H), 5.88(brs, 1H), 6.81(s, 1H), 6.94(d, J=8.1Hz, 
               
               
                   
                 2H), 7.02–7.14(m, 3H), 7.37–7.56(m, 7H) 
               
               
                   
                 IR(KBr) 3409, 2933, 1612, 1522, 1488, 1454, 1400, 1266, 1229, 1199, 1162, 1007, 834, 696cm −1   
               
               
                 I-1267 
                 mp 87–88° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.13(s, 3H), 2.59(s, 3H), 3.20(s, 3H), 3.55(s, 3H), 5.22(s, 2H), 6.99–7.17(m, 5H), 7.34–7.48(m, 6H), 
               
               
                   
                 7.67(d, J=8.4Hz, 2H) 
               
               
                   
                 IR(KBr) 3428, 2931, 1612, 1522, 1488, 1454, 1400, 1266, 1230, 1163, 1007, 835cm −1   
               
               
                 I-1268 
                 mp 76–77° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.72(s, 3H), 1.77(s, 6H), 1.81(s, 3H), 2.69(s, 3H), 3.24(s, 3H), 3.61(s, 3H), 3.79(s, 3H), 4.12–4.20(m, 
               
               
                   
                 1H), 4.55–4.61(m, 1H), 4.64(d, J=6.6Hz, 2H), 5.25(t, J=7.5Hz, 1H), 5.50(t, J=6.4Hz, 1H), 6.85(s, 1H), 7.05–7.11(m, 
               
               
                   
                 2H), 7.34–7.40(m, 3H) 
               
               
                   
                 IR(KBr) 3423, 2939, 1707, 1521, 1484, 1367, 1241, 1178, 1079, 1034, 972, 799, 521cm −1   
               
               
                 I-1269 
                 mp 73–74° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.17(s, 3H), 2.28(s, 3H), 5.16(s, 2H), 5.71(brs, 1H), 6.83(d, J=8.1Hz, 1H), 6.97–7.00(m, 2H), 7.08 
               
               
                   
                 (s, 1H), 7.15(s, 1H), 7.32–7.33(m, 2H), 7.36–7.45(m, 5H), 7.60(d, J=10.5Hz, 1H), 8.05(brs, 1H) 
               
               
                   
                 IR(KBr) 3410, 2923, 1718, 1606, 1540, 1521, 1489, 1424, 1282, 1179, 976, 728cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 252 
               
               
                   
               
             
            
               
                 I-1270 
                 mp 65–67° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.14(s, 3H), 2.72(s, 3H), 3.20(s, 3H), 3.56(s, 3H), 4.64(d, J=6.9Hz, 2H), 
               
               
                   
                 5.53(t, J=6.6Hz, 1H), 7.01–7.11(m, 3H), 7.18(s, 1H), 7.37(d, J=8.7Hz, 2H), 7.67(d, J=8.7Hz, 2H), 
               
               
                   
                 IR(KBr) 3434, 2938, 1519, 1478, 1365, 1267, 1176, 1151, 968, 871, 799, 524cm −1   
               
               
                 I-1271 
                 mp 99–100° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 6H), 1.79(s, 3H), 1.81(s, 3H), 3.52(s, 3H), 3.72(s, 3H), 4.61(d, J=7.2Hz, 2H), 5.36(t, J=6.6Hz, 
               
               
                   
                 1H), 5.53(t, J=5.7Hz, 1H), 5.69(brs, 1H), 5.81(brs, 1H), 6.43(s, 1H), 6.46–6.52(m, 1H), 6.95(s, 2H), 7.05(s, 1H), 
               
               
                   
                 7.10–7.16(m, 1H) 
               
               
                   
                 IR(KBr) 3496, 3407, 2933, 1638, 1535, 1493, 1098, 1000cm −1   
               
               
                 I-1272 
                 mp 75–76° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.17(s, 3H), 2.28(s, 3H), 3.12(s, 3H), 5.18(s, 2H), 7.09–7.14(m, 4H), 7.26–7.47(m, 8H), 7.61(d, J=11.4Hz, 
               
               
                   
                 1H), 8.00(brs, 1H) 
               
               
                   
                 IR(KBr) 3330, 2927, 1731, 1607, 1541, 1521, 1488, 1364, 1290, 1169, 1105, 975, 878, 811cm −1   
               
               
                 I-1273 
                 mp 112–113° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.11(s, 3H), 3.47(s, 3H), 4.64(d, J=6.6Hz, 2H), 4.83(brs, 1H), 5.56(t, J=7.2Hz, 
               
               
                   
                 1H), 5.84(brs, 1H), 6.78(s, 1H), 6.91(d, J=8.7Hz, 2H), 7.02–7.10(m, 3H), 751(d, J=8.4Hz, 2H), 
               
               
                   
                 IR(KBr) 3498, 2978, 1613, 1522, 1487, 1453, 1302, 1204, 1232, 1196, 987, 812cm −1   
               
               
                 I-1274 
                 oil 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.73(s, 3H), 1.76(s, 3H), 1.77(s, 3H), 1.79(s, 3H), 2.22(s, 3H), 2.27(s, 3H), 3.73(d, J=6.0Hz, 2H), 
               
               
                   
                 3.88(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.36(t, J=6.0Hz, 1H), 5.57(t, J=6.6Hz, 1H), 6.40–6.51(m, 2H), 6.87–6.95(m, 3H), 
               
               
                   
                 7.05–7.14(m, 3H) 
               
               
                   
                 IR(CHCl 3 ) 3021, 2934, 1628, 1523, 1492, 1235, 1219, 1139cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 253 
               
               
                   
               
             
            
               
                 I-1275 
                 mp 64–65° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.74(s, 3H), 1.77(s, 6H), 1.82(s, 3H), 2.16(s, 3H), 2.29(s, 3H), 3.23(s, 3H), 4.36(d, J=7.5Hz, 2H), 
               
               
                   
                 4.64(d, J=6.3Hz, 2H), 5.28(t, J=8.4Hz, 1H), 5.51(t, J=6.3Hz, 1H), 7.01–7.16(m, 6H), 7.24–7.35(m, 2H) 
               
               
                   
                 IR(KBr) 3422, 2926, 1698, 1519, 1489, 1367, 1209, 1170, 962, 807cm −1   
               
               
                 I-1276 
                 oil 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.21(s, 3H), 2.26(s, 3H), 3.95(d, J=6.6Hz, 2H), 4.28(brs, 1H), 4.78(d, J=6.0Hz, 2H), 6.05(t, J=6.3Hz, 
               
               
                   
                 1H), 6.24(t, J=6.3Hz, 1H), 6.36–6.49(m, 2H), 6.97–7.15(m, 6H) 
               
               
                   
                 IR(CHCl 3 ) 3446, 3009, 1628, 1525, 1492, 1274, 1224, 1130, 883cm −1   
               
               
                 I-1277 
                 mp 64–65° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(s, 6H), 1.85(s, 3H), 2.23(s, 3H), 2.30(s, 3H), 3.74(d, J=6.3Hz, 2H), 4.64(d, J=6.0Hz, 
               
               
                   
                 2H), 5.38(t, J=6.6Hz, 1H), 5.55(t, J=6.9Hz, 1H), 5.73(brs, 1H), 6.41–6.50(m, 2H), 6.84–7.15(m, 6H) 
               
               
                   
                 IR(KBr) 3354, 2971, 1627, 1522, 1490, 1274, 1200, 1128, 990, 843cm −1   
               
               
                 I-1278 
                 mp 153–154° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 1.95(s, 12H), 4.64(d, J=6.9Hz, 2H), 4.78(s, 1H), 5.57(t, J=6.9Hz, 1H), 
               
               
                   
                 6.85(ddd, J=8.3, 2.1, 1.2Hz, 1H), 6.90(d, J=8.6Hz, 2H), 6.92(dd, J=12.0, 2.1Hz, 1H), 7.04(d, J=8.6Hz, 2H), 7.04(t, J=8.3Hz, 
               
               
                   
                 1H), 
               
               
                   
                 IR(KBr) 3433, 1514, 1293, 1262, 1242, 1112, 984cm −1   
               
               
                 I-1279 
                 mp 115–117° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 2.23(s, 3H), 3.21(s, 3H), 3.81(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.55(t, J=6.6Hz, 
               
               
                   
                 1H), 6.81(s, 1H), 7.02(t, J=8.6Hz, 1H), 7.20(s, 1H), 7.24–7.28(m, 1H), 7.33–7.44(m, 3H) 
               
               
                   
                 IR(KBr) 3434, 1522, 1492, 1337, 1218, 1200, 1148, 979, 876cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 254 
               
               
                   
               
             
            
               
                 I-1280 
                 mp 88–90° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(s, 3H), 2.24(s, 3H), 3.80(s, 3H), 4.63(d, J=6.7Hz, 2H), 4.88(br s, 1H), 5.55(t, J=6.7Hz, 
               
               
                   
                 1H), 6.83(s, 1H), 6.90(d, J=8.7Hz, 2H), 7.01(t, J=8.6Hz, 1H), 7.18(s, 1H), 7.24–7.28(m, 3H), 7.36(dd, J=12.9, 
               
               
                   
                 2.1Hz, 1H) 
               
               
                   
                 IR(KBr) 3400, 1523, 1493, 1263, 1217, 1128, 977, 836cm −1   
               
               
                 I-1281 
                 mp 158–159° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(d, J=0.3Hz, 3H), 2.10(s, 3H), 2.34(s, 3H), 2.50(s, 3H), 3.87(s, 3H), 4.63(d, J=6.9Hz, 
               
               
                   
                 2H), 5.14(s, 1H), 5.55(m, 1H), 5.88(s, 1H), 6.77–6.82(m, 2H), 6.85–6.91(m, 2H), 6.98(d, J=8.1Hz, 1H), 7.13(s, 1H), 
               
               
                   
                 7.18–7.24(m, 2H) 
               
               
                   
                 IR(KBr) 3465, 1610, 1516, 1473, 1382, 1322, 1307, 1266, 1240, 1213, 1179, 1168, 1147, 1100, 982, 836cm −1   
               
               
                 I-1282 
                 mp 85–86° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 0.99(d, J=6.2Hz, 6H), 1.71–1.98(m, 3H), 2.27(s, 3H), 2.29(s, 3H), 3.20(s, 3H), 3.88(s, 3H), 4.10(t, J=6.8Hz, 
               
               
                   
                 2H), 6.88(dd, J=2.0, 8.6Hz, 1H), 6.88(d, J=2.0Hz, 1H), 6.95(d, J=8.6Hz, 1H), 7.30–7.46(m, 4H) 
               
               
                   
                 IR(KBr) 1519, 1488, 1375, 1255, 1243, 1214, 1204, 1173, 1154, 1134, 867, 850, 792cm −1   
               
               
                 I-1283 
                 mp 117–118° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 0.99(d, J=6.3Hz, 6H), 1.75–1.94(m, 3H), 2.27(s, 3H), 2.28(s, 3H), 3.88(s, 3H), 4.10(t, J=6.6Hz, 
               
               
                   
                 2H), 4.91(s, 1H), 6.86–6.91(m, 4H), 6.94(d, J=8.7Hz, 1H), 7.12(s, 1H), 7.15(s, 1H), 7.22–7.27(m, 2H) 
               
               
                   
                 IR(KBr) 3438, 1611, 1522, 1490, 1475, 1464, 1446, 1256, 1242, 1212, 1180, 1171, 1137, 1032, 834, 818cm −1   
               
               
                 I-1284 
                 mp 156–157° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.46(s, 3H), 3.76(s, 3H), 3.89(s, 3H), 4.78(d, J=6.3Hz, 2H), 4.99(s, 1H), 5.96(s, 1H), 6.25(t, J=6.3Hz, 
               
               
                   
                 1H), 6.47(s, 1H), 6.90–6.95(m, 2H), 6.93(d, J=7.8Hz, 1H), 7.04(dd, J=2.1, 7.8Hz, 1H), 7.04(d, J=2.1Hz, 1H), 
               
               
                   
                 7.51–7.57(m, 2H) 
               
               
                   
                 IR(KBr) 3455, 1612, 1522, 1487, 1456, 1396, 1269, 1234, 1223, 1209, 1173, 1140, 1115, 1024, 885, 825, 813cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 255 
               
               
                   
               
             
            
               
                 I-1285 
                 mp 84–85° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.00(d, J=6.6Hz, 6H), 1.71–1.96(m, 3H), 2.27(s, 6H), 4.11(t, J=6.9Hz, 2H), 4.80(br s, 1H), 6.86–6.92 
               
               
                   
                 (m, 2H), 6.97–7.14(m, 5H), 7.22–7.27(m, 2H) 
               
               
                   
                 IR(KBr) 3389, 1523, 1491, 1476, 1427, 1301, 1276, 1233, 1196, 1168, 1126, 836, 815cm −1   
               
               
                 I-1286 
                 mp 152–153° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(d, J=0.6Hz, 3H), 2.12(s, 3H), 2.20(s, 3H), 3.39(s, 3H), 3.87(s, 3H), 4.64(d, J=6.3Hz, 
               
               
                   
                 2H), 4.79(br s, 1H), 5.56–5.61(m, 1H), 6.82–6.97(m, 6H), 7.21–7.26(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 3440, 3011, 2935, 1676, 1612, 1588, 1518, 1473, 1449, 1259, 1238, 1173cm −1   
               
               
                 I-1287 
                 mp 123–125° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ −0.01–0.08(m, 2H), 0.44–0.50(m, 2H), 1.01(m, 1H), 3.21(s, 3H), 3.34(d, J=7.5Hz, 2H), 3.75(s, 3H), 
               
               
                   
                 3.91(s, 3H), 5.21(s, 2H), 6.08(s, 1H), 6.45(s, 1H), 6.97–7.04(m, 3H), 7.26–7.72(m, 9H) 
               
               
                 I-1288 
                 mp 177–178° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 0.27(t, J=4.8Hz, 1H), 0.60(dd, J=4.8, 8.7Hz, 1H), 1.13(s, 3H), 1.17(s, 3H), 1.13–1.22(m, 1H), 3.46 
               
               
                   
                 (s, 3H), 3.75(s, 3H), 3.80(s, 3H), 4.00(dd, J=7.8, 10.5Hz, 1H), 4.12(dd, J=6.6, 10.5Hz, 1H), 4.95(bs, 1H), 5.91(s, 1H), 
               
               
                   
                 6.46(s, 1H), 6.91–7.02(m, 5H), 7.52–7.56(m, 2H) 
               
               
                   
                 IR(KBr) 3479, 3434, 3389, 2940, 1614, 1589, 1523, 1490, 1466, 1395, 1361, 1319, 1271, 1238, 1218, 1174, 1137, 1117, 
               
               
                   
                 1072, 1011cm −1   
               
               
                 I-1289 
                 mp 153–155° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.80(s, 3H), 2.25(s, 3H), 3.80(s, 3H), 3.89(s, 3H), 4.63–4.65(d, J=6.6Hz, 2H), 4.80(br, 
               
               
                   
                 1H), 5.57(m, 1H), 6.86–6.97(m, 6H), 7.18(s, 1H), 7.45–7.48(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 1609, 1523, 1493, 1464, 1387, 1256, 1173, 1138, 1042, 1032, 997, 834cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 256 
               
               
                   
               
             
            
               
                 I-1290 
                 mp 150–152° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.25(s, 3H), 3.80(s, 3H), 3.90(s, 3H), 4.74–4.80(m, 3H), 6.26(t, J=6.0Hz, 1H), 6.85–6.92(m, 6H), 
               
               
                   
                 7.19(s, 1H), 7.45–7.48(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 3596, 2958, 2938, 1609, 1523, 1493, 1464, 1389, 1328, 1257, 1173, 1140, 1102, 1030, 886, 854, 834cm −1   
               
               
                 I-1291 
                 mp 117–118° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.79(s, 3H), 2.28(s, 3H), 2.31(s, 3H), 3.01(s, 6H), 3.88(s, 3H), 4.63(d, J=6.6Hz, 2H), 
               
               
                   
                 5.53–5.60(m, 1H), 6.76–6.96(m, 5H), 7.15(s, 2H), 7.28(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 1611, 1529, 1490, 1447, 1359, 1322, 1239, 1214, 1193, 1135, 1038,cm −1   
               
               
                 I-1292 
                 mp 116–118° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) 2.24(s, 3H), 3.81(s, 3H), 4.77(d, J=6.3Hz, 2H), 4.90(br s, 1H), 6.23(t, J=6.3Hz, 1H), 6.83(s, 1H), 6.90 
               
               
                   
                 (d, J=8.7Hz, 2H), 6.99(t, J=8.6Hz, 1H), 7.17(s, 1H), 7.25(d, J=8.7Hz, 2H), 7.27(ddd, J=8.6, 2.1, 1.2Hz, 1H), 7.37 
               
               
                   
                 (dd, J=12.6, 2.1Hz, 1H) 
               
               
                   
                 IR(KBr) 3596, 1731, 1613, 1523, 1493, 1259, 1130, 1033, 885cm −1   
               
               
                 I-1293 
                 mp 151–154° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.23(s, 3H), 3.21(s, 3H), 3.80(s, 3H), 3.93(s, 3H), 5.20(s, 2H), 6.81(s, 1H), 6.95(d, J=8.4Hz, 1H), 
               
               
                   
                 7.05(dd, J=8.4, 2.1Hz, 1H), 7.15(d, J=2.1Hz, 1H), 7.21(s, 1H), 7.30–7.50(m, 9H) 
               
               
                   
                 IR(KBr) 1490, 1361, 1243, 1148, 1032, 876cm −1   
               
               
                 I-1294 
                 mp 119–121° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.79(s, 3H), 2.24(s, 3H), 3.21(s, 3H), 3.80(s, 3H), 3.91(s, 3H), 4.63(d, J=6.5Hz, 2H), 
               
               
                   
                 5.56(t, J=6.5Hz, 1H), 6.82(s, 1H), 6.94(d, J=8.4Hz, 1H), 7.10(dd, J=8.4, 1.5Hz, 1H), 7.13(d, J=1.5Hz, 1H), 7.23(s, 
               
               
                   
                 1H), 7.36(d, J=8.3Hz, 2H), 7.43(d, J=8.3Hz, 2H) 
               
               
                   
                 IR(KBr) 1519, 1490, 1364, 1156, 1031, 971, 858cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 257 
               
               
                   
               
             
            
               
                 I-1295 
                 mp 135–137° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.75(s, 3H), 1.78(s, 3H), 2.25(s, 3H), 3.80(s, 3H), 3.90(s, 3H), 4.63(d, J=6.7Hz, 2H), 4.95(s, 1H), 
               
               
                   
                 5.56(t, J=6.7Hz, 1H), 6.84(s, 1H), 6.90(d, J=8.7Hz, 2H), 6.94(d, J=8.3Hz, 1H), 7.10(dd, J=8.3, 2.1Hz, 1H), 7.13(d, 
               
               
                   
                 J=2.1Hz, 1H), 7.21(s, 1H), 7.26(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr) 3423, 1609, 1523, 1493, 1258, 1219, 1142, 1033, 834cm −1   
               
               
                 I-1296 
                 mp 140–141° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.46(t, J=6.9Hz, 3H), 3.46(s, 3H), 3.75(s, 3H), 4.13(q, J=6.9Hz, 2H), 4.77(d, J=6.0Hz, 2H), 5.05 
               
               
                   
                 (s, 1H), 5.95(s, 1H), 6.25(t, J=6.0Hz, 1H), 6.47(s, 1H), 6.90–6.97(m, 3H), 7.01–7.06(m, 2H), 7.50–7.57(m, 2H) 
               
               
                   
                 IR(KBr) 3463, 3433, 1613, 1521, 1491, 1259, 1400, 1267, 1235, 1204, 1167, 1136, 1112, 1097, 1076, 1019, 993, 882, 824, 
               
               
                   
                 811cm −1   
               
               
                 I-1297 
                 mp 204–205° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 2.21(s, 3H), 2.22(s, 3H), 2.87(s, 3H), 3.02(s, 3H), 4.96(s, 2H), 6.80–6.86(m, 2H), 7.05–7.11(m, 
               
               
                   
                 4H), 7.13–7.19(m, 2H), 7.20–7.27(m, 1H) 
               
               
                   
                 IR(KBr) 3153, 1644, 1590, 1522, 1487, 1437, 1314, 1264, 1231, 1197, 1127, 1067, 833cm −1   
               
               
                 I-1298 
                 mp 155–158° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.21(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.42(s, 4H), 5.93(s, 1H), 6.44(s, 1H), 6.90–6.96(m, 1H), 7.06–7.11 
               
               
                   
                 (m, 1H), 7.19–7.39(m, 13H), 7.67–7.72(m, 2H) 
               
               
                   
                 IR(KBr) 3445, 2940, 1615, 1521, 1483, 1367, 1149, 875, 707, 546, 526cm −1   
               
               
                 I-1299 
                 mp 174–175° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.15(s, 3H), 3.20(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 4.40(s, 4H), 6.82(s, 1H), 6.91–7.01(m, 2H), 7.11–7.39 
               
               
                   
                 (m, 13H), 7.65–7.70(m, 2H) 
               
               
                   
                 IR(KBr) 3028, 2936, 1618, 1520, 1482, 1365, 1176, 1151, 1079, 871, 798, 698, 527cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 258 
               
               
                   
               
             
            
               
                 I-1300 
                 mp 218–221° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.69(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 6.83(s, 1H), 6.86–6.93(m, 1H), 7.02–7.15(m, 2H), 
               
               
                   
                 7.35–7.41(m, 2H), 7.66–7.71(m, 2H) 
               
               
                   
                 IR(KBr) 3435, 3389, 2940, 1635, 1525, 1362, 1175, 1152, 1076, 962, 874, 802, 527cm −1   
               
               
                 I-1301 
                 mp 209–211° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.91(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 6.86(s, 1H), 7.26–7.33(m, 2H), 7.37–7.42(m, 2H), 
               
               
                   
                 7.64–7.71(m, 2H), 8.15(s, 1H), 8.34–8.41(m, 1H) 
               
               
                   
                 IR(KBr) 3336, 2943, 1736, 1539, 1480, 1356, 1174, 1151, 1077, 881, 799, 523, 507cm −1   
               
               
                 I-1302 
                 powder 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.50(s, 3H), 1.71(s, 3H), 2.78(s, 3H), 3.23(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 4.11–4.20(m, 1H), 4.54–4.63 
               
               
                   
                 (m, 1H), 5.20–5.28(m, 1H), 6.87(s, 1H), 7.25–7.31(m, 3H), 7.37–7.42(m, 2H), 7.66–7.72(m, 2H) 
               
               
                   
                 IR(KBr) 2941, 1702, 1482, 1369, 1203, 1176, 1152, 1080, 964, 873, 797, 525cm −1   
               
               
                 I-1303 
                 mp 133–136° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.73(s, 3H), 1.77(s, 3H), 3.45(s, 3H), 3.74–3.78(m, 5H), 4.96(s, 1H), 5.34–5.42(m, 1H), 5.94(s, 1H), 
               
               
                   
                 6.45(s, 1H), 6.75–6.81(m, 1H), 6.89–6.95(m, 2H), 7.10–7.18(m, 2H), 7.51–7.56(m, 2H) 
               
               
                   
                 IR(KBr) 3401, 2935, 1626, 1614, 1527, 1490, 1402, 1267, 1223, 1113, 1071, 1005, 829, 589cm −1   
               
               
                 I-1304 
                 mp 170–171° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.11(s, 3H), 3.47(s, 3H), 4.40(s, 4H), 4.91(s, 1H), 5.81(s, 1H), 6.77(s, 1H), 6.86–7.08(m, 5H), 7.22–7.33 
               
               
                   
                 (m, 10H), 7.48–7.53(m, 2H) 
               
               
                   
                 IR(KBr) 3483, 3029, 1612, 1523, 1489, 1453, 1400, 1265, 1215, 834, 749, 698, 494, 526cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 259 
               
               
                   
               
             
            
               
                 I-1305 
                 mp 166–168° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.15(s, 3H), 2.17(s, 3H), 3.19(s, 3H), 4.21–4.59(m, 4H), 6.84–7.05(m, 3H), 7.14–7.15(m, 1H), 7.20–7.38 
               
               
                   
                 (m, 12H), 7.63–7.69(m, 2H) 
               
               
                   
                 IR(KBr) 3028, 2938, 1519, 1476, 1454, 1363, 1174, 1151, 969, 873, 801, 700, 525cm −1   
               
               
                 I-1306 
                 mp 210–212° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.11(s, 3H), 2.90(s, 3H), 3.44(s, 3H), 3.52(s, 3H), 6.82–7.02(m, 3H), 7.30(s, 1H), 7.44–7.49(m, 2H), 
               
               
                   
                 7.65–7.71(m, 2H) 
               
               
                   
                 IR(KBr) 3401, 2850, 1632, 1478, 1365, 1177, 1151, 967, 877, 800, 526cm −1   
               
               
                 I-1307 
                 mp 171–173° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.13(s, 3H), 2.95(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 7.17–7.22(m, 3H), 7.35–7.41(m, 2H), 7.64–7.69(m, 
               
               
                   
                 2H), 8.17(s, 1H), 8.37–8.43(m, 1H) 
               
               
                   
                 IR(KBr) 3431, 3034, 2942, 1741, 1538, 1478, 1364, 1291, 1152, 971, 870, 801, 525cm −1   
               
               
                 I-1308 
                 powder 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.47(s, 3H), 1.70(s, 3H), 2.11(s, 3H), 2.67–3.15(m, 3H), 3.22(s, 3H), 3.56(s, 3H), 4.13–4.22(m, 1H), 
               
               
                   
                 4.54–4.63(m, 1H), 5.21–5.28(m, 1H), 7.09–7.42(m, 6H), 7.63–7.71(m, 2H) 
               
               
                   
                 IR(CHCl 3 ) 2940, 1700, 1519, 1478, 1372, 1175, 1151, 968cm −1   
               
               
                 I-1309 
                 mp 139–141° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.74(s, 3H), 1.78(s, 3H), 2.13(s, 3H), 3.48(s, 3H), 3.77(d, J=6.6Hz, 2H), 4.70–5.20(br s, 1H), 5.35–5.42 
               
               
                   
                 (m, 1H), 5.77(s, 1H), 6.77–6.83(m, 2H), 6.88–6.99(m, 4H), 7.48–7.54(m, 2H) 
               
               
                   
                 IR(KBr) 3525, 3377, 2931, 1625, 1526, 1488, 1222, 1164, 1011, 833cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 260 
               
               
                   
               
             
            
               
                 I-1310 
                 mp 177–179° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.76(s, 3H), 1.81(s, 3H), 3.20(t, J=8.4Hz, 2H), 3.21(t, J=8.4Hz, 2H), 4.521(d, J=7.2Hz, 2H), 
               
               
                   
                 4.523(t, J=8.4Hz, 2H), 4.90(brs, 1H), 5.53(t, J=6.8Hz, 1H), 6.71(s, 1H), 6.89(d, J=8.4Hz, 2H), 6.98(d, J=8.7Hz, 
               
               
                   
                 2H), 7.41(d, J=8.7Hz, 2H), 7.45(d, J=9.0Hz, 2H) 
               
               
                   
                 IR(KBr)3389, 2971, 2911, 1611, 1525, 1394, 1238, 1175, 997, 828cm −1   
               
               
                 I-1311 
                 mp 175–177° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.20(t, J=8.3Hz, 4H), 4.53(t, J=8.4Hz, 4H), 4.70(d, J=6.3Hz, 2H), 4.88(brs, 1H), 6.19(t, J=6.2Hz, 
               
               
                   
                 1H), 6.89(d, J=8.7Hz, 2H), 6.96(d, J=9.0Hz, 2H), 7.41(d, J=9.0Hz, 2H), 7.47(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3409, 3269, 2934, 2901, 1524, 1480, 1395, 1235, 1223, 1003, 881, 817cm −1   
               
               
                 I-1312 
                 mp 186–187° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.06(s, 3H), 2.16(s, 3H), 4.72(s, 1H), 4.80(d, J=6.3Hz, 2H), 4.83(s, 1H), 6.25(t, J=6.3Hz, 1H)6.76 
               
               
                   
                 (s, 1H), 6.86–6.92(m, 2H), 7.03–7.13(m, 3H), 7.21–7.26(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3689, 3598, 3551, 3024, 3008, 1732, 1614, 1520, 1487, 1260, 1223cm −1   
               
               
                 I-1313 
                 mp 201° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.08(s, 3H), 2.17(s, 3H), 3.88(s, 3H), 4.80(d, J=6.3Hz, 2H), 4.90(br s, 1H), 4.99(s, 1H), 6.26(t, J=6.3Hz, 
               
               
                   
                 1H), 6.77(s, 1H), 6.85–6.92(m, 4H), 7.01(d, J=6.9Hz, 1H), 7.22–7.27(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3688, 3598, 3538, 3024, 3014, 2938, 1731, 1631, 1520, 1488, 1240, 1172cm −1   
               
               
                 I-1314 
                 mp 132–134° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.12(s, 3H), 2.29(s, 3H), 3.00(s, 6H), 3.74(br, 2H), 6.62(dd, J=2.4, 8.1Hz, 1H), 6.77–6.82(m, 3H), 
               
               
                   
                 7.01–7.05(m, 2H), 7.12(s, 1H), 7.26–7.31(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1610, 1523, 1483, 1443, 1325, 1297cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 261 
               
               
                   
               
             
            
               
                 I-1315 
                 mp 123–125° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.13(s, 3H), 2.29(m, 4H), 3.00(s, 6H), 3.98(br, 3H), 6.63(dd, J=2.4, 8.1Hz, 1H), 6.77–6.81(m, 3H), 
               
               
                   
                 7.02(s, 1H), 7.09–7.13(m, 2H), 7.25–7.32(m, 2H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1609, 1525, 1488, 1443, 1356, 1232, 1194cm −1   
               
               
                 I-1316 
                 mp 125–127° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.10(s, 3H), 2.31(s, 3H), 3.01(s, 6H), 6.77–6.84(m, 2H), 7.00(s, 1H), 7.15(s, 1H), 7.27–7.33(m, 3H), 
               
               
                   
                 7.52(dd, J=3.0, 12.9Hz, 1H), 7.09(d, J=3.0Hz, 1H), 7.95(br s, 1H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1707, 1611, 1528, 1484, 1350, 1279, 1229, 1196, 1154cm −1   
               
               
                 I-1317 
                 mp 94–95° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.26(s, 6H), 4.63(d, J=6.6Hz, 2H), 5.51–5.60(m, 1H), 6.01(s, 2H), 6.78–6.89 
               
               
                   
                 (m, 3H), 6.97–7.15(m, 5H) 
               
               
                 I-1318 
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.29(s, 6H), 4.64(d, J=6.3Hz, 2H), 5.53–5.60(m, 1H), 6.99–7.21(m, 
               
               
                   
                 5H), 7.33–7.39(m, 2H), 7.49(d.d, J=5.4 &amp; 0.3Hz, 1H), 7.80(s, 1H), 7.92(d, J=8.1Hz, 1H) 
               
               
                 I-1319 
                 mp 188–189° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.31(t, J=7.5Hz, 3H), 2.26(s, 3H), 2.29(s, 3H), 2.68(q, J=7.5Hz, 2H), 5.17(s, 2H), 5.70(brs, 1H), 
               
               
                   
                 6.83(d, J=6.8Hz, 1H), 6.98–7.00(m, 2H), 7.13(d, J=9.0Hz, 2H), 7.26–7.30(m, 2H), 7.38–7.48(m, 5H), 7.78(brs, 1H), 7.86 
               
               
                   
                 (d, J=8.7Hz, 1H) 
               
               
                   
                 IR(KBr)3444, 3269, 1710, 1533, 1487, 1269, 1244, 1199, 1174, 744, 697cm −1   
               
               
                 I-1320 
                 mp 157–159° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.30(t, J=7.6Hz, 3H), 2.27(s, 3H), 2.28(s, 3H), 2.68(q, J=7.2Hz, 2H), 3.91(s, 3H), 5.21(s, 2H), 
               
               
                   
                 6.81–6.97(m, 3H), 7.14(d, J=7.6Hz, 2H), 7.25–7.51(m, 7H), 7.79(brs, 1H), 7.86(d, J=8.8Hz, 1H) 
               
               
                   
                 IR(KBr)3434, 3260, 1707, 1519, 1501, 1488, 1260, 1241, 1213, 1172, 744, 697cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 262 
               
               
                   
               
             
            
               
                 I-1321 
                 mp 186–187° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.30(t, J=8.4Hz, 3H), 2.26(s, 3H), 2.27(s, 3H), 2.68(q, J=7.5Hz, 2H), 5.20(s, 2H), 7.04–7.14(m, 
               
               
                   
                 6H), 7.26–7.50(m, 6H), 7.79(brs, 1H), 7.86(d, J=8.7Hz, 1H) 
               
               
                   
                 IR(KBr)3436, 3266, 1709, 1536, 1521, 1487, 1267, 1199, 1176, 744, 697cm −1   
               
               
                 I-1322 
                 mp 136–137° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.32(t, J=7.5Hz, 3H), 2.28(s, 3H), 2.30(s, 3H), 2.70(q, J=7.5Hz, 2H), 3.13(s, 3H), 5.19(s, 2H), 
               
               
                   
                 7.12–7.15(m, 3H), 7.26–7.29(m, 3H), 7.37–7.50(m, 5H), 7.80(brs, 1H), 7.87(d, J=9.0Hz, 1H) 
               
               
                   
                 IR(KBr)3435, 1725, 1536, 1486, 1363, 1292, 1266, 1179, 1163, 1108, 7970, 895, 811, 525cm −1   
               
               
                 I-1323 
                 mp 150–151° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.18(s, 3H), 2.27(s, 3H), 5.20(s, 2H), 7.04–7.14(m, 6H), 7.26–7.50(m, 6H), 7.60(d, J=12.0Hz, 1H), 
               
               
                   
                 7.94(brs, 1H) 
               
               
                   
                 IR(KBr)3421, 3302, 1712, 1523, 1490, 1422, 1299, 1274, 1205, 1176, 1132, 743, 697cm −1   
               
               
                 I-1324 
                 mp 83–84° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.30(t, J=7.6Hz, 3H), 1.77(s, 3H), 1.78(s, 3H), 1.81(s, 6H), 2.31(s, 3H), 2.34(s, 3H), 2.56(q, J=7.6Hz, 
               
               
                   
                 2H), 3.80(d, J=6.4Hz, 2H), 3.90(s, 3H), 4.65(d, J=6.2Hz, 2H), 5.44(d, J=6.2Hz, 2H), 5.44(t, J=5.2Hz, 1H), 5.59 
               
               
                   
                 (t, J=5.4Hz, 1H), 6.73(d, J=8.0Hz, 1H), 6.92–6.94(m, 3H), 7.12–7.20(m, 4H) 
               
               
                   
                 IR(KBr)3428, 3374, 2964, 1607, 1519, 1494, 1458, 1311, 1256, 1239, 1139, 1036, 1002, 855, 820cm −1   
               
               
                 I-1325 
                 mp 113–114° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.30(t, J=7.4Hz, 3H), 1.76(s, 3H), 1.78(s, 3H), 1.80(s, 3H), 1.84(s, 3H), 2.30(s, 3H), 2.32(s, 3H), 
               
               
                   
                 2.55(q, J=7.6Hz, 2H), 3.79(d, J=6.6Hz, 2H), 4.63(d, J=6.6Hz, 2H), 5.43(t, J=5.6Hz, 1H), 5.55(t, J=6.6Hz, 1H), 
               
               
                   
                 5.73(brs, 1H), 6.72(d, J=8.0Hz, 1H), 6.83–6.98(m, 3H), 7.11–7.19(m, 4H) 
               
               
                   
                 IR(KBr)3413, 3298, 2965, 2924, 1518, 1494, 1435, 1242, 1127, 1013, 883cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 263 
               
               
                   
               
             
            
               
                 I-1326 
                 mp 81–82° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.29(t, J=7.4Hz, 3H), 1.74(s, 3H), 1.77(s, 3H), 1.78(s, 3H), 1.81(s, 3H), 2.27(s, 3H), 2.31(s, 3H), 
               
               
                   
                 2.54(q, J=7.2Hz, 2H), 3.79(d, J=7.2Hz, 2H), 4.63(d, J=6.6Hz, 2H), 5.42(t, J=6.4Hz, 1H), 5.55(t, J=6.6Hz, 1H), 
               
               
                   
                 6.71(d, J=8.0Hz, 1H), 7.04–7.19(m, 7H) 
               
               
                   
                 IR(KBr)3413, 2969, 2912, 2856, 1613, 1520, 1492, 1295, 1261, 1127, 1004, 881, 813cm −1   
               
               
                 I-1327 
                 mp 94–95° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.74(s, 3H), 1.77(s, 6H), 1.81(s, 3H), 2.21(s, 3H), 2.26(s, 3H), 3.72(d, J=6.9Hz, 2H), 4.63(d, J=6.3Hz, 
               
               
                   
                 2H), 5.35(t, J=6.9Hz, 1H), 5.55(t, J=6.9Hz, 1H), 6.37–6.48(m, 2H), 7.01–7.13(m, 6H) 
               
               
                   
                 IR(KBr)3423, 2967, 2918, 1627, 1525, 1488, 1296, 1267, 1129, 981, 837, 805cm −1   
               
               
                 I-1328 
                 mp 178–180° C.(decomp.) 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 3.30(s, 3H), 3.64(s, 3H), 4.45(s, 2H), 5.65(s, 2H), 6.39(s, 1H), 6.65(dd, J=8.4, 2.1Hz, 1H), 6.74 
               
               
                   
                 (d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.99(d, J=8.4Hz, 1H), 7.43(d, J=8.7Hz, 2H), 9.26(s, 1H) 
               
               
                   
                 IR(Nujol)3487, 3382, 1696, 1670, 1591, 1523, 1491, 1458, 1243, 1202, 1114, 1077, 1013, 937, 811cm −1   
               
               
                 I-1329 
                 mp 205–210° C.(decomp.) 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 3.34(s, 3H), 3.44(s, 3H), 3.67(s, 3H), 4.93(s, 2H), 6.43(s, 1H), 6.76(dd, J=8.4, 2.1Hz, 1H), 6.85 
               
               
                   
                 (d, J=2.1Hz, 1H), 6.86(d, J=8.7Hz, 2H), 7.04(d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3388, 3333, 3270, 1671, 1614, 1579, 1556, 1523, 1443, 1223, 1172, 1121, 1033, 922, 813cm −1   
               
               
                 I-1330 
                 mp 185–187° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.79(t, J=2.6Hz, 3H), 2.69(m, 2H), 2.75(s, 3H), 3.21(s, 3H), 3.29(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 
               
               
                   
                 4.17(t, J=6.6Hz, 2H), 6.84(s, 1H), 7.08(d, J=9.0Hz, 1H), 7.36(dd, J=9.0, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, 
               
               
                   
                 J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)1604, 1520, 1480, 1175, 1151, 1081, 1012, 971, 948, 878, 840, 807cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 264 
               
               
                   
               
             
            
               
                 I-1331 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.81(t, J=2.4Hz, 3H), 2.65(m, 2H), 3.45(s, 3H), 3.74(s, 3H), 4.16(t, J=6.6Hz, 2H), 6.45(s, 1H), 
               
               
                   
                 6.92(d, J=8.7Hz, 2H), 6.95(m, 2H), 7.07(brs, 1H), 7.07(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3427, 1612, 1586, 1523, 1489, 1251, 1224, 1113, 1071, 1012cm −1   
               
               
                 I-1332 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 4.16(m, 2H), 4.76(m, 2H), 5.89–6.02(m, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 
               
               
                   
                 2H), 6.96(m, 2H), 7.09(brs, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3433, 1612, 1588, 1523, 1489, 1286, 1248, 1224, 1175, 1113, 1070, 1011cm −1   
               
               
                 I-1333 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.74(s, 3H), 4.11(m, 2H), 4.67(m, 2H), 5.96–6.12(m, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 
               
               
                   
                 2H), 6.92(d, J=8.4Hz, 1H), 6.96(dd, J=8.4, 2.1Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(Nujol)3434, 1612, 1588, 1523, 1489, 1285, 1248, 1224, 1174, 1112, 1070, 1011cm −1   
               
               
                 I-1334 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.95(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.11(s, 2H), 4.68(d, J=6.9Hz, 2H), 5.75(d, J=6.9Hz, 1H), 
               
               
                   
                 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.96(s, 2H), 7.08(s, 1H), 7.53(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3390, 1612, 1585, 1523, 1491, 1225, 1072, 1003, 822cm −1   
               
               
                 I-1335 
                 m.p 179–180° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.88(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.07(s, 2H), 4.69(d, J=6.6Hz, 2H), 5.89(d, J=6.6Hz, 1H), 
               
               
                   
                 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.92(d, J=8.4Hz, 1H), 6.96(dd, J=1.8, 8.4Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.53(d, 
               
               
                   
                 J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3392, 1609, 1584, 1523, 1492, 1226, 1116, 1072, 1002, 813, 782cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 265 
               
               
                   
               
             
            
               
                 I-136 
                 foam 
               
               
                   
                   1 H NMR(CD3OD) δ 3.38(s, 3H), 3.67(s, 3H), 3.88(dd, J=7.8, 9.9Hz, 1H), 4.10(dd, J=3.6, 9.9Hz, 1H), 4.51(m, 1H), 
               
               
                   
                 5.25(dt, J=10.5, 1.5Hz, 1H), 5.44(dt, J=17.4, 1.5Hz, 1H), 6.00(ddd, J=5.4, 10.5, 17.4Hz, 1H), 6.43(s, 1H), 6.79(dd, J=1.8, 
               
               
                   
                 8.4Hz, 1H), 6.85(d, J=8.7Hz, 2H), 6.86(d, J=1.8Hz, 1H), 6.92(d, J=8.4Hz, 1H), 7.45(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3399, 2934, 1612, 1588, 1523, 1489, 1254, 1114, 1071, 1012, 939, 816cm −1   
               
               
                 I-1337 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.45(s, 3H), 3.75(s, 3H), 4.20(t, J=2.1Hz, 2H), 4.84(t, J=2.1Hz, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 
               
               
                   
                 2H), 6.98(dd, J=2.1, 8.4Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.45(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3431, 1612, 1589, 1523, 1489, 1404, 1224, 1113, 1070, 1011, 939, 826cm −1   
               
               
                 I-1338 
                 foam 
               
               
                   
                   1 H NMR(CD3OD) δ 3.38(s, 3H), 3.67(s, 3H), 4.25(d, J=21.0Hz, 2H), 4.84(d, J=7.5Hz, 2H), 5.58(dt, J=19.5, 7.5Hz, 
               
               
                   
                 1H), 6.43(s, 1H), 6.79(dd, J=2.1, 8.4Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.86(d, J=2.1Hz, 1H), 6.96(d, J=8.4Hz, 1H), 
               
               
                   
                 7.45(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3409, 1701, 1612, 1591, 1523, 1489, 1404, 1246, 1113, 1071, 1010, 939, 816cm −1   
               
               
                 I-1339 
                 foam 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.44(s, 3H), 3.74(s, 3H), 4.21(d, J=21.3Hz, 2H), 4.66(dd, J=1.8, 7.5Hz, 2H), 5.70(dt, J=16.5, 7.5Hz, 
               
               
                   
                 1H), 6.45(s, 1H), 6.95(d, J=8.7Hz, 2H), 6.96(d, J=8.4Hz, 1H), 6.98(dd, J=1.5, 8.4Hz, 1H), 7.09(d, J=1.5Hz, 1H), 
               
               
                   
                 7.51(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3411, 1698, 1611, 1588, 1522, 1488, 1223, 1112, 1070, 1011, 939, 825cm −1   
               
               
                 I-1340 
                 mp 171–172° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.50(s, 3H), 1.67(s, 3H), 1.96(s, 3H), 3.45(s, 3H), 3.77(s, 3H), 4.13–4.49(m, 2H), 5.23–5.30(m, 1H), 
               
               
                   
                 5.59(s, 1H), 6.13(s, 1H), 6.47(s, 1H), 6.92–6.98(m, 2H), 7.18–7.35(m, 3H), 7.50–7.57(m, 2H) 
               
               
                   
                 IR(KBr)3390, 3140, 2935, 1640, 1523, 1401, 1240, 1119, 1070, 835, 820cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 266 
               
               
                   
               
             
            
               
                 I-1341 
                 mp 216–218° C. 
               
               
                   
                   1 H NMR(CDCl 3 +CD3OD) δ 1.46(s, 3H), 1.67(s, 3H), 1.95(s, 3H), 2.10(s, 3H), 3.46(s, 3H), 4.16–4.47(m, 2H), 5.21–5.28 
               
               
                   
                 (m, 1H), 6.79(s, 1H), 6.88–6.95(m, 2H), 7.11–7.27(m, 3H), 7.45–7.52(m, 2H) 
               
               
                   
                 IR(KBr)3337, 3099, 2928, 1637, 1608, 1587, 1521, 1444, 1409, 1261, 1232, 1161, 836, 769, 592, 540cm −1   
               
               
                 I-1342 
                 mp 103–105° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.15(d, J=6.8Hz, 6H), 2.26(s, 3H), 3.08(sept, J=6.8Hz, 1H), 4.94(s, 1H), 5.20(s, 2H), 6.88(d, J=8.7Hz, 
               
               
                   
                 2H), 7.04–7.07(m, 3H), 7.12–7.18(m, 1H), 7.18(s, 1H), 7.20(d, J=8.7Hz, 2H), 7.32–7.51(m, 5H) 
               
               
                   
                 IR(KBr)3429, 1522, 1490, 1262, 1227, 1128, 1011, 833cm −1   
               
               
                 I-1343 
                 mp 115–117° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.15(d, J=6.6Hz, 6H), 1.77(s, 3H), 1.82(s, 3H), 2.27(s, 3H), 3.08(sept, J=6.8Hz, 1H), 4.64(d, J=6.9Hz, 
               
               
                   
                 2H), 4.86(s, 1H), 5.56(t, J=6.9Hz, 1H), 6.89(d, J=8.6Hz, 2H), 7.03(t, J=8.4Hz, 1H), 7.05–7.19(m, 3H), 7.19(s, 
               
               
                   
                 1H), 7.21(d, J=8.6Hz, 2H) 
               
               
                   
                 IR(KBr)3524, 1611, 1523, 1489, 1260, 1228, 1200, 1128, 836cm −1   
               
               
                 I-1344 
                 mp 119–120° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.15(d, J=6.9Hz, 6H), 2.26(s, 3H), 3.08(sept, J=6.8Hz, 1H), 4.79(d, J=6.3Hz, 2H), 4.85(s, 1H), 
               
               
                   
                 6.25(t, J=6.3Hz, 1H), 6.89(d, J=8.7Hz, 2H), 7.01(t, J=8.4Hz, 1H), 7.07–7.12(m, 2H), 7.15(dd, J=12.0, 2.1Hz, 1H), 
               
               
                   
                 7.18(s, 1H), 7.20(d, J=8.7Hz, 2H) 
               
               
                   
                 IR(KBr)3425, 1610, 1523, 1488, 1300, 1263, 1300, 1263, 1227, 1134, 1038, 896cm −1   
               
               
                 I-1345 
                 mp 109–110° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.34(d, J=6.9Hz, 3H), 2.24(s, 3H), 4.00(q, J=6.9Hz, 2H), 4.77–4.79(m, 3H), 6.24(t, J=6.3Hz, 
               
               
                   
                 1H), 6.86–6.90(m, 2H), 6.98–7.19(m, 4H), 7.47–7.50(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3596, 2927, 1612, 1523, 1493, 1476, 1388, 1299, 1259, 1173, 1127, 1049, 885, 834cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 267 
               
               
                   
               
             
            
               
                 I-1346 
                 mp 114–116° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.33(d, J=6.9Hz, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.24(s, 3H), 4.00(q, J=6.9Hz, 2H), 4.63(m, 2H), 
               
               
                   
                 4.73(br, 1H), 5.56(m, 1H), 6.81(s, 1H), 6.86–6.90(m, 2H), 7.00–7.19(m, 4H), 7.47–4.51(m, 2H) 
               
               
                   
                 IR(CHCl 3 )3596, 2929, 2877, 1610, 1523, 1493, 1476, 1386, 1329, 1316, 1297, 1261, 1173, 1125, 1048, 992, 834cm −1   
               
               
                 I-1347 
                 mp 144–146° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 3.20(s, 3H), 3.40(s, 3H), 3.75(s, 3H), 4.74(s, 2H), 5.19(s, 2H), 6.44(s, 1H), 7.05–7.62(m, 12H) 
               
               
                   
                 IR(KBr)3437, 1614, 1579, 1520, 1488, 1465, 1453, 1436, 1414, 1393, 1364, 1346, 1299, 1270, 1235, 1198, 1175, 1149, 
               
               
                   
                 1129, 1114, 1085, 1063cm −1   
               
               
                 I-1348 
                 mp 156–159° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.48(s, 3H), 3.05(s, 3H), 3.20(s, 3H), 3.78(s, 3H), 4.83(s, 2H), 5.21(s, 2H), 6.84(s, 1H), 7.02–7.67(m, 
               
               
                   
                 12H) 
               
               
                   
                 IR(KBr)3430, 2940, 1607, 1522, 1481, 1452, 1419, 1389, 1365, 1294, 1273, 1230, 1200, 1176, 1151, 1132, 1080, 1011cm −1   
               
               
                 I-1349 
                 mp 155–156° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.15(t, J=6.9Hz, 3H), 3.60(q, J=6.9Hz, 2H), 3.75(s, 3H), 3.90(s, 3H), 4.93(bs, 1H), 5.20(s, 2H), 
               
               
                   
                 5.98(s, 1H), 6.46(s, 1H), 6.90–7.05(m, 5H), 7.26–7.56(m, 7H) 
               
               
                   
                 IR(KBr)3409, 2938, 1613, 1522, 1438, 1416, 1396, 1382, 1360, 1268, 1232, 1211, 1169, 1131, 1113, 1078, 1022, 1006cm −1   
               
               
                 I-1350 
                 mp 58–60° C. 
               
               
                   
                   1 H NMR(DMSO-d 6 ) δ 1.71(s, 6H), 2.21(s, 3H), 2.22(s, 3H), 3.71–3.75(m, 2H), 5.11(br s, 2H), 5.25–5.29(m, 1H), 5.50–5.53 
               
               
                   
                 (m, 1H), 6.60–6.63(m, 2H), 6.66–6.73(m, 1H), 6.95–7.05(m, 6H) 
               
               
                   
                 IR(KBr)3600–2800(br), 1623, 1527, 1492, 1454, 1428, 1331, 1269, 1257, 1184, 1116cm −1   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 268 
               
               
                   
               
             
            
               
                 I-1351 
                 mp 140–142° C.(dec.) 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 2.33(s, 3H), 4.93(s, 1H), 5.19(s, 2H), 6.89(d, J=8.7Hz, 2H), 7.06(t, J=8.6Hz, 1H), 7.23(d, J=8.7Hz, 
               
               
                   
                 2H), 7.24–7.50(m, 10H) 
               
               
                   
                 IR(KBr)3400, 1609, 1529, 1490, 1269, 1243, 1005, 807, 745cm −1   
               
               
                 I-1352 
                 mp 114–116° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.81(s, 3H), 2.33(s, 3H), 4.63(d, J=6.9Hz, 2H), 4.89(s, 1H), 5.54(t, J=6.9Hz, 1H), 
               
               
                   
                 6.89(d, J=8.6Hz, 2H), 7.04(t, J=8.6Hz, 1H), 7.23(d, J=8.6Hz, 2H), 7.25–7.43(m, 5H) 
               
               
                   
                 IR(KBr)3368, 1609, 1526, 1490, 1271, 1241, 1131, 991, 827, 811cm −1   
               
               
                 I-1353 
                 mp 78–79° C. 
               
               
                   
                   1 H NMR(CDCl 3 ) δ 1.77(s, 3H), 1.82(s, 3H), 2.24(s, 3H), 2.27(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.51–5.59(m, 1H), 6.98–7.20 
               
               
                   
                 (m, 7H), 7.28–7.36(m, 2H) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 269 
               
             
            
               
                   
               
               
                   
                 (I) 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 No. 
                 R 1   
                 R 2   
                 R 3   
                 R 4   
                 R 5   
                 R 6   
                 R 7   
                 R 8   
                 R 9   
                 R 10   
                 R 11   
                 R 12   
                 R 13   
                 X 
                 Y 
               
               
                   
               
               
                 I-1354 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1355 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1356 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1357 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1358 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1359 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1360 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1361 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1362 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1363 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1364 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1365 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1366 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1367 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1368 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1369 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 270 
               
               
                   
               
             
            
               
                 I-1370 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1371 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1372 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1373 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1374 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1375 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1376 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1377 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1378 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1379 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1380 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1381 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1382 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1383 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1384 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1385 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1386 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1387 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1388 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1389 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1390 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 271 
               
               
                   
               
             
            
               
                 I-1391 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1392 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1393 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1394 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1395 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1396 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1397 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1398 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1399 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1400 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1401 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1402 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1403 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1404 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1405 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1406 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1407 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1408 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1409 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1410 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1411 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 272 
               
               
                   
               
             
            
               
                 I-1412 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1413 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1414 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1415 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1416 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1417 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1418 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1419 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1420 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1421 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1422 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1423 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1424 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1425 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1426 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1427 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1428 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1429 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1430 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1431 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1432 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 273 
               
               
                   
               
             
            
               
                 I-1433 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1434 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1435 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1436 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1437 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1438 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1439 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1440 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1441 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1442 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1443 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1444 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1445 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1446 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1447 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1448 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1449 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1450 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1451 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1452 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1453 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 274 
               
               
                   
               
             
            
               
                 I-1454 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1455 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1456 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1457 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1458 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1459 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1460 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1461 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1462 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1463 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1464 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1465 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1466 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1467 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1468 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1469 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1470 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1471 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1472 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1473 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1474 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 275 
               
               
                   
               
             
            
               
                 I-1475 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1476 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1477 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1478 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1479 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1480 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1481 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1482 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1483 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1484 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1485 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1486 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1487 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1488 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1489 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1490 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1491 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1492 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1493 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1494 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1495 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 276 
               
               
                   
               
             
            
               
                 I-1496 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1497 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1498 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1499 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1500 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1501 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1502 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1503 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-154 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1505 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1506 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1507 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1508 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1509 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1510 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1511 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1512 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1513 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1514 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1515 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1516 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 277 
               
               
                   
               
             
            
               
                 I-1517 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1518 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1519 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1520 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1521 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1522 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1523 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1524 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1525 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1526 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1527 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1528 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1529 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1530 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1531 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1532 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1533 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1534 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1535 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1536 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1537 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 278 
               
               
                   
               
             
            
               
                 I-1538 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1539 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1540 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1541 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1542 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1543 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1544 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1545 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1546 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1547 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1548 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1549 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1550 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1551 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1552 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1553 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1554 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1555 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1556 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1557 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1558 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 279 
               
               
                   
               
             
            
               
                 I-1559 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1560 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1561 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1562 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1563 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1564 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1565 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1566 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1567 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1568 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1569 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1570 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1571 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1572 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1573 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1574 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1575 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1576 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1577 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1578 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1579 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 280 
               
               
                   
               
             
            
               
                 I-1580 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1581 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1582 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1583 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1584 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1585 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1586 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1587 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1588 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1589 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1590 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1591 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1592 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1593 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1594 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1595 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1596 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1597 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1598 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1599 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1600 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 281 
               
               
                   
               
             
            
               
                 I-1601 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1602 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1603 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1604 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1605 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1606 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1607 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1608 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1609 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1610 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1611 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1612 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1613 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1614 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1615 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1616 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1617 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1618 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1619 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1620 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1621 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 282 
               
               
                   
               
             
            
               
                 I-1622 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1623 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1624 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1625 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1626 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1627 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1628 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1629 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1630 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1631 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1632 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1633 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1634 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1635 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1636 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1637 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1638 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1639 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1640 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1641 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1642 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 283 
               
               
                   
               
             
            
               
                 I-1643 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1644 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1645 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COCH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1646 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1647 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1648 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1649 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1650 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1651 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1652 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1653 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1654 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1655 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1656 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1657 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1658 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1659 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1660 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1661 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1662 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1663 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 284 
               
               
                   
               
             
            
               
                 I-1664 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1665 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1666 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1667 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1668 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1669 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1670 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1671 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1672 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1673 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1674 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1675 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1676 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1677 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1678 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1679 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1680 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1681 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1682 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1683 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1684 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 285 
               
               
                   
               
             
            
               
                 I-1685 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1686 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1687 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1688 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1689 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1690 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1691 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1692 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1693 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1694 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1695 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1696 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1697 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1698 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1699 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1700 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1701 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1702 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1703 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1704 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1705 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 286 
               
               
                   
               
             
            
               
                 I-1706 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1707 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1708 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1709 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1710 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1711 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1712 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1713 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1714 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1715 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1716 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1717 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1718 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1719 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1720 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1721 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1722 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1723 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1724 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1725 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1726 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 287 
               
               
                   
               
             
            
               
                 I-1727 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1728 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1729 
                 F 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1730 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1731 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1732 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1733 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1734 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1735 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1736 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1737 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1738 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1739 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1740 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1741 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1742 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1743 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1744 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1745 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1746 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1747 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 288 
               
               
                   
               
             
            
               
                 I-1748 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1749 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1750 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1751 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1752 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1753 
                 F 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1754 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1755 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1756 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1757 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1758 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1759 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1760 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1761 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1762 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1763 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1764 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1765 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1766 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1767 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1768 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 289 
               
               
                   
               
             
            
               
                 I-1768 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1769 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1770 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1771 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1772 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1773 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1774 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1775 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1776 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1777 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1778 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1779 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1780 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1781 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1782 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1783 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1784 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1785 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1786 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1787 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1788 
                 —OCH 2 O— * 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 290 
               
               
                   
               
             
            
               
                 I-1789 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1790 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1791 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1792 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1793 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1794 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1795 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1796 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1797 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1798 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1799 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1800 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1801 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1802 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1803 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1804 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1805 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1806 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1807 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1808 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1809 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 291 
               
               
                   
               
             
            
               
                 I-1810 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1811 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1812 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1813 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1814 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1815 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1816 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1817 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1818 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1819 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1820 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1821 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1822 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1823 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1824 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1825 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1826 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1827 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1828 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1829 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1830 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 292 
               
               
                   
               
             
            
               
                 I-1831 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1832 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1833 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1834 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1835 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1836 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1837 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1838 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1839 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1840 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1841 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1842 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1843 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1844 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1845 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1846 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1847 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1848 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1849 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1850 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1851 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 293 
               
               
                   
               
             
            
               
                 I-1852 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1853 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1854 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1855 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1856 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1857 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1858 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1859 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1860 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1861 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1862 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1863 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1864 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1865 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1866 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1867 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1868 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1869 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1870 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1871 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1872 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 294 
               
               
                   
               
             
            
               
                 I-1873 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1874 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1875 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1876 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1877 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1878 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1879 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1880 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1881 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1882 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1883 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1884 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1885 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1886 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1887 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1888 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1889 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1890 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1891 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1892 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1893 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 295 
               
               
                   
               
             
            
               
                 I-1894 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1895 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1896 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1897 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1898 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1899 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1900 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1901 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1902 
                 —OCH 2 O—* 
                 H 
                 H 
                 * 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1903 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1904 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1905 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1906 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1907 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1908 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1909 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1910 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1911 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1912 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1913 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1914 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 296 
               
               
                   
               
             
            
               
                 I-1915 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1916 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1917 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1918 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1919 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1920 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1921 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1922 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1923 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1924 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1925 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1926 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1927 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1928 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1929 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1930 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1931 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1932 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1933 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1934 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1935 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 297 
               
               
                   
               
             
            
               
                 I-1936 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1937 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1938 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-199 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-190 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1941 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1942 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1943 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1944 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1945 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1946 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1947 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1948 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1949 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1950 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1951 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1952 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1953 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1954 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1955 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1956 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 298 
               
               
                   
               
             
            
               
                 I-1957 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1958 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1959 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1960 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1961 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1962 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1963 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1964 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1965 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1966 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1967 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-198 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1969 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1970 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1971 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1972 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1973 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1974 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1975 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1976 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1977 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 299 
               
               
                   
               
             
            
               
                 I-1978 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1979 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1980 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1981 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1982 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1983 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1984 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1985 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1986 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1987 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1988 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1989 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1990 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1991 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1992 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1993 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-1994 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-1995 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-1996 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-1997 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-1998 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 300 
               
               
                   
               
             
            
               
                 I-1999 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2000 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2001 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2002 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2003 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2004 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2005 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2006 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2007 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2008 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2009 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2010 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2011 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2012 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2013 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2014 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2015 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2016 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2017 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2018 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2019 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 301 
               
               
                   
               
             
            
               
                 I-2020 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2021 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2022 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2023 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2024 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2025 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2026 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2027 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2028 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2029 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2030 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2031 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2032 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2033 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2034 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2035 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2036 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2037 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2038 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2039 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2040 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 302 
               
               
                   
               
             
            
               
                 I-2041 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2042 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2043 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2044 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2045 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2046 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2047 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2048 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2049 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2050 
                 NMe 2   
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2051 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2052 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2053 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2054 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2055 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2056 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2057 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2058 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2059 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2060 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2061 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 303 
               
               
                   
               
             
            
               
                 I-2062 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2063 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2064 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2065 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2066 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2067 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2068 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2069 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2070 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2071 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2072 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2073 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2074 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2075 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2076 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2077 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2078 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2079 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2080 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2081 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2082 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 304 
               
               
                   
               
             
            
               
                 I-2083 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2084 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2085 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2086 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2087 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2088 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2089 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2090 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2091 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2092 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2093 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2094 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2095 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2096 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2097 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2098 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 COOH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2099 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2100 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2101 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2102 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2103 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 305 
               
               
                   
               
             
            
               
                 I-2104 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2105 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2106 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2107 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2108 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2109 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2110 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2111 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2112 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2113 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2114 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2115 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2116 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2117 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2118 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2119 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2120 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2121 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2122 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2123 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 CH 2 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2124 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 306 
               
               
                   
               
             
            
               
                 I-2125 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2126 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2127 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2128 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2129 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2130 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2131 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2132 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2133 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2134 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2135 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2136 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2137 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2138 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2139 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2140 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2141 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2142 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2143 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2144 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2145 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 307 
               
               
                   
               
             
            
               
                 I-2146 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2147 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2148 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2149 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2150 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2151 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2152 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2153 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2154 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2155 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2156 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2157 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2158 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2159 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2160 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2161 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2162 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2163 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2164 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2165 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2166 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 308 
               
               
                   
               
             
            
               
                 I-2167 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2168 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2169 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH≡CMe 2   
               
               
                 I-2170 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH≡CMe 2   
               
               
                 I-2171 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2172 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2173 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2174 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2175 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2176 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2177 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2178 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2179 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2180 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2181 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2182 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2183 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2184 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2185 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2186 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2187 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C≡CMe 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 309 
               
               
                   
               
             
            
               
                 I-2188 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 COOH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2189 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2190 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2191 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2192 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2193 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 CH 2 OH 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2194 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2195 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2196 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2197 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C≡CMe 
               
               
                 I-2198 
                 COOH 
                 H 
                 H 
                 H 
                 H 
                 F 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 F 
                 O 
                 —CH 2 C 6 H 4 -4-Me 
               
               
                 I-2199 
                 NO 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2200 
                 OMs 
                 NO 2   
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2201 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 NO 2   
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2202 
                 CN 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2203 
                 OMs 
                 CN 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 H 
                 H 
                 H 
                 H 
                 OMs 
                 O 
                 —(CH 2 ) 2 CH═CMe 2   
               
               
                 I-2204 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2205 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2206 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2207 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2208 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 310 
               
               
                   
               
             
            
               
                 I-2209 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2210 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2211 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2212 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2213 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 NH 2   
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2214 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 NH 2   
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2215 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 NH 2   
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2216 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2217 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2218 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2219 
                 OH 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2220 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2221 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2222 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2223 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2224 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2225 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2226 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2227 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2228 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2229 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 311 
               
               
                   
               
             
            
               
                 I-2230 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2231 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2232 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 NH 2   
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2233 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 NH 2   
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2234 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 NH 2   
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2235 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2236 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2237 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2238 
                 OMs 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2239 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2240 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2241 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2242 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2243 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2244 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2245 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2246 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2247 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2248 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2249 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2250 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 312 
               
               
                   
               
             
            
               
                 I-2251 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 NH 2   
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2252 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 NH 2   
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2253 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 NH 2   
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2254 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 NH 2   
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2255 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2256 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2257 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2258 
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2259 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2260 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2261 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2262 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OMs 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2263 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2264 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2265 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2266 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2267 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2268 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2269 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2270 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2271 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 NH 2   
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 313 
               
               
                   
               
             
            
               
                 I-2272 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 NH 2   
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2273 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 NH 2   
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2274 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 NH 2   
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2275 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2276 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OH 
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2277 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2278 
                 NH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 NH 2   
                 O 
                 —CH 2 C 6 H 5   
               
               
                 I-2279 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2280 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2281 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2282 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2283 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2284 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2285 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2286 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2287 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2288 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2289 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2290 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2291 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2292 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 314 
               
               
                   
               
             
            
               
                 I-2293 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2294 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2295 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2296 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2297 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2298 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2299 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2300 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2301 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2302 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2303 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2304 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2305 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2306 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2307 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2308 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2309 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2330 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2331 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2332 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2333 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 315 
               
               
                   
               
             
            
               
                 I-2334 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2335 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2336 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2337 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2338 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2339 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2340 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2341 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2342 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2343 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2344 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2345 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2346 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2347 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2348 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2349 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2350 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2351 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2352 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2353 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2354 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 316 
               
               
                   
               
             
            
               
                 I-2355 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2356 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2357 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2358 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2359 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2360 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2361 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2362 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2363 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2364 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2365 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2366 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2367 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2368 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2369 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2370 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2371 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2372 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2373 
                 —NHCH 2 CH═CMe 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2374 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2375 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 317 
               
               
                   
               
             
            
               
                 I-2376 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2377 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2378 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2379 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-230 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2381 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2382 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2383 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2384 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2385 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2386 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2387 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2388 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2389 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2390 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2391 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2392 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2393 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2394 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2395 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2396 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 318 
               
               
                   
               
             
            
               
                 I-2397 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2398 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2399 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2400 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2301 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2302 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2303 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2304 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2305 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2306 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-237 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2308 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2309 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2310 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2311 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2312 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2313 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2314 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2315 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-236 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-237 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 319 
               
               
                   
               
             
            
               
                 I-2318 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2319 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-230 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2321 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2322 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2323 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2324 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2325 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-236 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2327 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2328 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2329 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2330 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2331 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2332 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2333 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2334 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2335 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2336 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2337 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2338 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 320 
               
               
                   
               
             
            
               
                 I-2339 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2340 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2341 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2342 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2343 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2344 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2345 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2346 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2347 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2348 
                 —NH 2   
                 H 
                 F 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2349 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2350 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2351 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2352 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2353 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2354 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2355 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2356 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2357 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2358 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2359 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 321 
               
               
                   
               
             
            
               
                 I-2360 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2361 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2362 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2363 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2364 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2365 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2366 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2367 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2368 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2369 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2370 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2371 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2372 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2373 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2374 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2375 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2376 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2377 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2378 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2379 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2380 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 322 
               
               
                   
               
             
            
               
                 I-2381 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2382 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2383 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2384 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2385 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-236 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2387 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2388 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2389 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2390 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2391 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2392 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2393 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2394 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2395 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2396 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2397 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2398 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2399 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2400 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2401 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 323 
               
               
                   
               
             
            
               
                 I-2402 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2403 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2404 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2405 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2406 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2407 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2408 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2409 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2410 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2411 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2412 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2413 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2414 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2415 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2416 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2417 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2418 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2419 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2420 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2421 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2422 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 324 
               
               
                   
               
             
            
               
                 I-2423 
                 —NHCH 2 CH═CMe 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2424 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2425 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2426 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2427 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2428 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2429 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2430 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2431 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2432 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2433 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2434 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2435 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2436 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2437 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2438 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2439 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2440 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2441 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2442 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2443 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 325 
               
               
                   
               
             
            
               
                 I-2444 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2445 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2446 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2447 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2448 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2449 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2450 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2451 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2452 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2453 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 OMe 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2454 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2455 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2456 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2457 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2458 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2459 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2460 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2461 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2462 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2463 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2464 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 326 
               
               
                   
               
             
            
               
                 I-2465 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 -(CH 2 ) 2 CHMe2 
               
               
                 I-2466 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2467 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe2 
               
               
                 I-2468 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 H 
                 Me 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2469 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2470 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2471 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2472 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2473 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2474 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2475 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2476 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2477 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 O 
                 CH 2 CH═CMe 2   
               
               
                 I-2478 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2479 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2480 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2481 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2482 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2483 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 Me 
                 Me 
                 Me 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2484 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2485 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 327 
               
               
                   
               
             
            
               
                 I-2486 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 NMe 
                 Me 
               
               
                 I-2487 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2488 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OMe 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2489 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2490 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2491 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 NMe 
                 Me 
               
               
                 I-2492 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2493 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 F 
                 H 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                 I-2494 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —CH 2 CH═CMe 2   
               
               
                 I-2495 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NH 
                 —(CH 2 ) 2 CHMe 2   
               
               
                 I-2496 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 NMe 
                 Me 
               
               
                 I-2497 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CMe 2   
               
               
                 I-2498 
                 —OMe 
                 H 
                 H 
                 H 
                 H 
                 H 
                 OMe 
                 OEt 
                 OH 
                 H 
                 H 
                 H 
                 OEt 
                 O 
                 —CH 2 CH═CCl 2   
               
               
                   
               
            
           
         
       
     
     In the above tables, “—OCH 2 O—*” and “*” mean that they taken together form a ring. 
     Experiment 1 
     Suppressive Effect on a Mitogenic Activity of Mouse Splenocytes In Vitro 
     In 96-well microtiter plate 5×10 5  C3H/HeN mouse splenocytes suspended in 0.1 ml of 10% fetal bovine serum-fortified RPMI 1640 medium containing 2 mM of sodium bicarbonate, 50 units/ml of penicillin, 50 μg/ml of streptomycin and 5×10 −5  M of 2-mercaptoethanol were added. Then, 5 μg/ml of Concanavalin A (Con A) or 10 μg/ml of lipopolysaccharide (LPS) as a mitogen and the compound of a pre-determined concentration of the present invention were added to each well so that a final volume of each well reached 0.2 ml. Each compound of the present invention was dissolved in dimethylsulfoxide (DMSO) and diluted with the above RPMI 1640 medium to adjust the final concentration of 100 ng/ml or less. The splenocytes in the 96-well microtiter plate were cultivated at 37° C. for 3 days in an incubator keeping the humidity 100%, carbon dioxide 5% and air 95%. Then, 25 μl of 6 mg/ml MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (Sigma) was added to the each well and cultivated at 37° C. for 4 hours under the same conditions. After the cultivation, 50 μl of 0.02 N hydrochloric acid in 20% sodium dodecyl sulfate (SDS) was added to formazan generated and left at 37° C. for 24 hours for dissolving formazan. An absorption intensity (OD) of formazan generated in proportion to the number of living cells was measured with an immunoreader (InterMed) equipped with a 570 nm filter (The Journal of Immunological Method, 65, 55–63, 1983). The 50% inhibitory concentration of a cell proliferation (IC  50 ) was calculated from a correlation between the concentration of the compound of the present invention and the absorption intensity. 
     Experiment 2 
     Anti-proliferative Activity on EL4 Cells 
     In 96-well microtiter plate 4×10 4 /0.1 ml of mouse thymoma strain EL4 cells were added and 0.1 ml of the compound of the present invention was added to the mixture so that the concentration was in the range of 0–5,000 ng/ml. After the cultivation for 3 days, the IC 50  was calculated by the MTT method as described in Experiment 1. 
     The results are shown in Tables 328–329. 
     
       
         
           
               
               
               
               
               
             
               
                   
                 TABLE 328 
               
               
                   
                   
               
               
                   
                   
                 ConA 
                 LPS 
                 EL-4 
               
               
                   
                   
                 IC 50   
                 IC 50   
                 IC 50   
               
               
                   
                 Compound 
                 (ng/ml) 
                 (ng/ml) 
                 (ngl/ml) 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 I-1 
                 0.86 
                 1.92 
                 8.56 
               
               
                   
                 I-9 
                 &lt;20 
                 &lt;20 
                 &lt;20 
               
               
                   
                 I-12 
                 1.3 
                 2.8 
                 46.2 
               
               
                   
                 I-22 
                 5.62 
                 4.26 
                 6.2 
               
               
                   
                 I-35 
                 19.5 
                 39.4 
                 140 
               
               
                   
                 I-40 
                 6.1 
                 16.5 
                 37.4 
               
               
                   
                 I-41 
                 0.73 
                 1.74 
                 4.89 
               
               
                   
                 I-46 
                 10.6 
                 23.9 
                 67.5 
               
               
                   
                 I-49 
                 8.89 
                 16.2 
                 31.7 
               
               
                   
                 I-50 
                 3.83 
                 9.2 
                 11.9 
               
               
                   
                 I-51 
                 6.6 
                 14.7 
                 70.0 
               
               
                   
                 I-59 
                 8.5 
                 22.4 
                 140 
               
               
                   
                 I-62 
                 29.2 
                 25 
                 23.4 
               
               
                   
                 I-63 
                 13 
                 27 
                 16 
               
               
                   
                 I-66 
                 0.22 
                 0.35 
                 0.48 
               
               
                   
                 I-71 
                 4.56 
                 14.2 
                 31.2 
               
               
                   
                 I-101 
                 0.8 
                 0.5 
                 1.8 
               
               
                   
                 I-103 
                 3.4 
                 3.7 
                 4.6 
               
               
                   
                 I-104 
                 3.0 
                 3.1 
                 4.8 
               
               
                   
                 I-106 
                 0.6 
                 0.4 
                 2.7 
               
               
                   
                 I-107 
                 0.6 
                 0.7 
                 12 
               
               
                   
                 I-121 
                 0.8 
                 1.2 
                 0.8 
               
               
                   
                 I-163 
                 &lt;20 
                 &lt;20 
                 &lt;20 
               
               
                   
                 I-173 
                 &lt;20 
                 &lt;20 
                 &lt;20 
               
               
                   
                 I-175 
                 &lt;20 
                 29.4 
                 &lt;20 
               
               
                   
                 I-187 
                 12.0 
                 25.1 
                 36.2 
               
               
                   
                 I-211 
                 &lt;20 
                 &lt;20 
                 &lt;20 
               
               
                   
                 I-248 
                 &lt;10 
                 &lt;10 
                 312 
               
               
                   
                 I-250 
                 &lt;10 
                 &lt;10 
                 88.3 
               
               
                   
                 I-251 
                 &lt;10 
                 &lt;10 
                 97.4 
               
               
                   
                 I-255 
                 &lt;20 
                 &lt;20 
                 &lt;20 
               
               
                   
                 I-256 
                 &lt;20 
                 28.7 
                 310 
               
               
                   
                 I-275 
                 6.34 
                 13.5 
                 100 
               
               
                   
                 I-276 
                 1.8 
                 3.1 
                 200 
               
               
                   
                 I-299 
                 5.53 
                 7.85 
                 13.6 
               
               
                   
                 I-301 
                 7.06 
                 11.0 
                 15.8 
               
               
                   
                 I-360 
                 &lt;20 
                 &lt;20 
                 99.8 
               
               
                   
                 I-361 
                 &lt;20 
                 &lt;20 
                 124 
               
               
                   
                 I-418 
                 255 
                 497 
                 &gt;10000 
               
               
                   
                 I-427 
                 255 
                 497 
                 &gt;10000 
               
               
                   
                 I-457 
                 &lt;20 
                 &lt;20 
                 205 
               
               
                   
                 I-466 
                 &lt;20 
                 &lt;20 
                 46 
               
               
                   
                 I-484 
                 14.7 
                 32.2 
                 91.4 
               
               
                   
                 I-513 
                 6.89 
                 11.1 
                 61.8 
               
               
                   
                 I-525 
                 0.76 
                 1.11 
                 5.0 
               
               
                   
                 I-639 
                 4.59 
                 6.25 
                 50 
               
               
                   
                 I-661 
                 0.67 
                 1.28 
                 50 
               
               
                   
                 I-739 
                 18.8 
                 20.7 
                 430 
               
               
                   
                 I-742 
                 10 
                 20 
                 45.2 
               
               
                   
                 I-758 
                 6.78 
                 9.63 
                 55.1 
               
               
                   
                 I-773 
                 8.45 
                 12.6 
                 92.9 
               
               
                   
                 I-797 
                 1.75 
                 3.71 
                 26.5 
               
               
                   
                 I-834 
                 36 
                 46 
                 226 
               
               
                   
                 I-839 
                 1.48 
                 1.87 
                 20.7 
               
               
                   
                 I-840 
                 5.31 
                 6.94 
                 31.9 
               
               
                   
                 I-878 
                 14.1 
                 27.4 
                 194 
               
               
                   
                 I-880 
                 23.0 
                 41.1 
                 105 
               
               
                   
                 I-892 
                 &lt;0.2 
                 &lt;0.2 
                 1.41 
               
               
                   
                 I-893 
                 0.49 
                 1.05 
                 7.06 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                   
                 TABLE 329 
               
               
                   
                   
               
               
                   
                   
                 ConA 
                 LPS 
                 EL-4 
               
               
                   
                   
                 IC 50   
                 IC 50   
                 IC 50   
               
               
                   
                 Compound 
                 (ng/ml) 
                 (ng/ml) 
                 (ng/ml) 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 I-907 
                 23.4 
                 44.5 
                 82.7 
               
               
                   
                 I-908 
                 0.45 
                 0.86 
                 3.50 
               
               
                   
                 I-909 
                 &lt;20 
                 &lt;20 
                 20 
               
               
                   
                 I-931 
                 2.93 
                 5.76 
                 4.37 
               
               
                   
                 I-934 
                 16.1 
                 22.2 
                 52.7 
               
               
                   
                 I-943 
                 2.97 
                 4.89 
                 46.8 
               
               
                   
                 I-962 
                 12.1 
                 16.3 
                 20.4 
               
               
                   
                 I-970 
                 &lt;20 
                 &lt;20 
                 50.3 
               
               
                   
                 I-976 
                 17.7 
                 34.2 
                 330 
               
               
                   
                 I-981 
                 14.9 
                 27.1 
                 &gt;100 
               
               
                   
                 I-982 
                 2.0 
                 3.75 
                 55.3 
               
               
                   
                 I-988 
                 0.2 
                 0.31 
                 1.23 
               
               
                   
                 I-993 
                 5.10 
                 7.54 
                 13.8 
               
               
                   
                 I-995 
                 20.9 
                 25.2 
                 49.2 
               
               
                   
                 I-1006 
                 8.66 
                 12.3 
                 33.0 
               
               
                   
                 I-1007 
                 8.05 
                 10.4 
                 13.1 
               
               
                   
                 I-1017 
                 9.74 
                 16.7 
                 72.9 
               
               
                   
                 I-1031 
                 &lt;20 
                 21.2 
                 41.7 
               
               
                   
                 I-1040 
                 1.80 
                 5.31 
                 1.85 
               
               
                   
                 I-1043 
                 2.19 
                 3.27 
                 9.70 
               
               
                   
                 I-1058 
                 21.2 
                 30.2 
                 48.8 
               
               
                   
                 I-1066 
                 3.91 
                 4.87 
                 20.6 
               
               
                   
                 I-1095 
                 6.90 
                 9.57 
                 34.2 
               
               
                   
                 I-1103 
                 4.7 
                 6.9 
                 31.4 
               
               
                   
                 I-1107 
                 5.8 
                 9.1 
                 34.1 
               
               
                   
                 I-1115 
                 &lt;20 
                 &lt;20 
                 &lt;20 
               
               
                   
                 I-1121 
                 3.12 
                 9.0 
                 18.6 
               
               
                   
                 I-1123 
                 0.80 
                 2.00 
                 3.9 
               
               
                   
                 I-1124 
                 94 
                 272 
                 &gt;10000 
               
               
                   
                 I-1126 
                 79 
                 234 
                 &gt;10000 
               
               
                   
                 I-1127 
                 44 
                 111 
                 412 
               
               
                   
                 I-1128 
                 5.00 
                 11.4 
                 26.0 
               
               
                   
                 I-1135 
                 1.00 
                 2.70 
                 11.7 
               
               
                   
                 I-1160 
                 10.6 
                 14.1 
                 97.4 
               
               
                   
                 I-1161 
                 2.4 
                 4.2 
                 33.2 
               
               
                   
                 I-1162 
                 0.65 
                 1.95 
                 30.9 
               
               
                   
                 I-1167 
                 0.08 
                 0.23 
                 8.1 
               
               
                   
                 I-1168 
                 0.26 
                 0.54 
                 12.5 
               
               
                   
                 I-1171 
                 0.63 
                 0.64 
                 27.5 
               
               
                   
                 I-1172 
                 13.1 
                 19.4 
                 &gt;100 
               
               
                   
                 I-1173 
                 16.4 
                 31.1 
                 &gt;100 
               
               
                   
                 I-1177 
                 12.2 
                 20.8 
                 47.2 
               
               
                   
                 I-1191 
                 0.16 
                 0.66 
                 22.8 
               
               
                   
                 I-1193 
                 1.46 
                 5.3 
                 50 
               
               
                   
                 I-1203 
                 14.1 
                 &gt;100 
                 43.5 
               
               
                   
                 I-1212 
                 12.87 
                 24.2 
                 85.0 
               
               
                   
                 I-1217 
                 &lt;20 
                 &lt;20 
                 &lt;20 
               
               
                   
                 I-1227 
                 197 
                 423 
                 &gt;10000 
               
               
                   
                 I-1229 
                 5.95 
                 8.05 
                 20.4 
               
               
                   
                 I-1230 
                 12.0 
                 15.3 
                 5.22 
               
               
                   
                 I-1232 
                 3.77 
                 4.93 
                 15.1 
               
               
                   
                 I-1240 
                 2.50 
                 3.34 
                 11.8 
               
               
                   
                 I-1248 
                 25.9 
                 36.8 
                 118 
               
               
                   
                 I-1250 
                 0.68 
                 1.35 
                 2.90 
               
               
                   
                 I-1251 
                 6.30 
                 10.7 
                 27.8 
               
               
                   
                 I-1263 
                 &lt;20 
                 &lt;20 
                 29.8 
               
               
                   
                 I-1271 
                 0.10 
                 0.32 
                 1.66 
               
               
                   
                 I-1274 
                 0.33 
                 1.38 
                 1.44 
               
               
                   
                 I-1276 
                 &lt;20 
                 31.3 
                 105 
               
               
                   
                 I-1277 
                 &lt;20 
                 &lt;20 
                 &lt;20 
               
               
                   
                 I-1278 
                 &lt;20 
                 &lt;20 
                 41.7 
               
               
                   
                 I-1284 
                 &lt;20 
                 &lt;20 
                 &lt;20 
               
               
                   
                 I-1286 
                 &lt;20 
                 &lt;20 
                 &lt;20 
               
               
                   
                 I-1289 
                 &lt;20 
                 &lt;20 
                 &lt;20 
               
               
                   
                 I-1290 
                 &lt;20 
                 &lt;20 
                 27.3 
               
               
                   
                 I-1295 
                 &lt;20 
                 &lt;20 
                 &lt;20 
               
               
                   
                 I-1296 
                 &lt;20 
                 &lt;20 
                 39.7 
               
               
                   
                   
               
            
           
         
       
     
     As shown in the above, the compound of the present invention has immunosuppressive and anti-allergic effects. 
     Experiment 3 
     Suppressive Effect on the Antibody Production Against bovine γ Globulin (BGG) 
     On an immunizing day and 7 days after, 50 μg of BGG was subcutaneously inoculated to backs of BALB/c mice (male, 6–8 weeks old) for inducing an immune reaction. After the compound of the present invention was dissolved or suspended in N,N-dimethylacetoamide, the mixture was diluted with miglyol 812 neutral oil. A proper volume of the compound was orally administered (p.o.) to mice every day from the next day of the immunizing. A two hundredth weight to body weight of miglyol was administered to mice in a control group. After 21 days, blood was drawn from each mouse and a serum was separated. BGG-specific IgE in a serum was measured by the sandwich ELISA method using a BGG-coating plate. The suppressive rate of IgE production was calculated from the dilution rate of the serum which has the same absorption intensity as that of the control group for judging the effect of the compound of the present invention. The results are shown in Table 330. 
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 330 
               
               
                   
                   
               
               
                   
                   
                   
                 Suppressive rate of 
               
               
                   
                   
                 Dose 
                 antigen-specific IgE 
               
               
                   
                 Compound 
                 (mg/kg) 
                 (%) 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 I-525 
                 100 
                 &gt;95 
               
               
                   
                 I-915 
                 100 
                 &gt;99 
               
               
                   
                 I-892 
                 5 
                 &gt;99 
               
               
                   
                 I-963 
                 50 
                 &gt;99 
               
               
                   
                 I-1031 
                 100 
                 &gt;99 
               
               
                   
                 I-1093 
                 100 
                 &gt;99 
               
               
                   
                   
               
            
           
         
       
     
     Experiment 4 
     Suppressive Effect on the IgE Production Against Ovalbumin (OVA) 
     1) Animals 
     BALB/c mice (female, 8–10 weeks old) and Wistar rats (female, 8–10 weeks old) which were bought from Japan SLC, Inc. (Shizuoka) were used. 
     2) Immunizing Method 
     BALB/c mice were immunized by an intraperitoneal administration of 0.2 ml suspension of 2 μg of ovalbumin (OVA) and 2 mg of aluminium hydroxide gel in physiological saline. After 10 days, blood was drawn from hearts, sera were separated and stocked at −40° C. till the measurement of an IgE antibody titer. 
     3) Compounds 
     After the compound of the present invention was dissolved or suspended in N,N-dimethylacetoamide, the mixture was diluted 20 times with miglyol 812 neutral oil. The obtained solution was orally administered to mice at 0.1 ml per mouse. The administration was continued for 10 days from the immunizing day to the day before drawing blood. IPD-1151-T (a compound described in Jpn. Pharmacol. (1993) 61, 31–39) and a compound No. 36 (a compound 36 described in J. Med. Chem. (1997) 40: 395–407) were examined as controls by the same method. 
     4) Measurement of Anti-OVA IgE Antibody Titer (PCA Titer) 
     The samples 2-fold diluted with physiological saline were prepared from the obtained mouse serum and each 50 μl of the solution was intradermauy injected to backs of Wistar rats which previously hair cut. After 24 hours, a passive cutaneous anaphylaxis reaction (PCA) was induced by an intravenous injection of 0.5 ml of physiological saline containing 1 mg of OVA and 5 mg of Evans&#39; blue dye. After 30 minutes, the rats were sacrified and the highest dilution rate of the serum giving bluing with a diameter of more than 5 mm was recorded as the PCA titer. For example, when a serum is positive for the PCA reaction till 2 7  times dilution, the anti-OVA IgE antibody titer of the mouse is defined as 7. The results are shown in Table 331. 
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 331 
               
               
                   
                   
               
               
                   
                   
                 Dose 
                   
               
               
                   
                 Compound 
                 (mg/kg) 
                 PCA Titer 
               
               
                   
                   
               
             
            
               
                   
                 I-484 
                 40 
                 &lt;0 
               
               
                   
                 I-839 
                 40 
                 2.4** 
               
               
                   
                 I-851 
                 40 
                 1.8** 
               
               
                   
                 I-892 
                 40 
                 &lt;0 
               
               
                   
                 I-893 
                 40 
                 2.5** 
               
               
                   
                 I-908 
                 40 
                 3.4** 
               
               
                   
                 I-915 
                 40 
                 &lt;0 
               
               
                   
                 I-925 
                 40 
                   1** 
               
               
                   
                 I-928 
                 40 
                 &lt;0 
               
               
                   
                 I-948 
                 40 
                 2.6** 
               
               
                   
                 I-957 
                 40 
                 4.5** 
               
               
                   
                 I-962 
                 40 
                 &lt;0 
               
               
                   
                 I-963 
                 40 
                 3.6** 
               
               
                   
                 I-988 
                 40 
                 0.8** 
               
               
                   
                 I-1031 
                 40 
                 4.4** 
               
               
                   
                 I-1043 
                 40 
                 4.8** 
               
               
                   
                 I-1066 
                 40 
                 &lt;0 
               
               
                   
                 I-1072 
                 40 
                 0.8** 
               
               
                   
                 I-1095 
                 40 
                 &lt;0 
               
               
                   
                 I-1123 
                 40 
                 2.4** 
               
               
                   
                 I-1135 
                 40 
                 4.8** 
               
               
                   
                 I-1167 
                 40 
                 4.4** 
               
               
                   
                 I-1171 
                 40 
                 &lt;0 
               
               
                   
                 I-1177 
                 40 
                 3.6** 
               
               
                   
                 I-1229 
                 40 
                 &lt;0 
               
               
                   
                 I-1232 
                 40 
                 1.8** 
               
               
                   
                 I-1242 
                 40 
                 2.8** 
               
               
                   
                 I-1258 
                 40 
                 1.2** 
               
               
                   
                 I-1271 
                 40 
                 &lt;0 
               
               
                   
                 IPD-1151-T 
                 50 
                  9.8 
               
               
                   
                 No. 36 
                 10 
                  10.4 
               
               
                   
                   
               
               
                   
                 **P &lt; 0.01 vs vehicle 
               
            
           
         
       
     
     The PCA titers of mice in a group to which any compound was not administered were 9–12. 
     IPD-1151-T . . . 
     
       
         
         
             
             
         
       
     
     As shown in the above, the compound of the present invention has a suppressive effect on the antibody production. 
     Experiment 5 
     Suppressive Effect on the Antibody Production of Human Lymphocytes 
     1. Experimental Method 
     
         
         1) Human Peripheral Blood 
       
    
     Human peripheral blood was drawn from healthy male adults by plastic syringes filled with heparin (final concentration 1.5%). Lymphocytes were collected immediately after blood was drawn.
     2) Medium   

     RPMI medium (Nissui Pharmaceutical Co., Ltd.) containing 10% fetal bovine serum (HyClone Lab.) inactivated at 56° C. for 30 minutes, penicillin (100 units/ml) and streptomycin (100 μg/ml) (GIBCO) was used.
     3) Compounds   

     After the compound (I-839) of the present invention was dissolved in dimethylsulfoxide (Nakaraitesk) at 2 μg/ml, the solution was diluted with the medium to adjust a final concentration to be 0.01 pg/ml–10 μg/ml. The compound No. 36 was examined as a control by the same method.
     4) Human Lymphocytes   

     Human peripheral blood was stratified in a tube filled with Ficoll-Hypaque mixture solution (Dainippon Pharmaceutical Co., Ltd. (Osaka), Mono-poly resolving medium) at the same volume and centrifuged at 300×g at 15° C. for 30 minutes to obtain a lymphocytes layer. After the collected cell suspension was washed with sterile Hanks&#39; solution (Nissui Pharmaceutical Co., Ltd.) by centrifugation, sterile distilled water was added to the suspension. After 30 seconds, twice-concentrated Hanks&#39; solution of which amount is equal to the water was added for removal of contaminating erythrocytes. Lymphocytes which were filtered by a nylon mesh and washed by centrifugation were used for experiments as human lymphocytes.
     5) Induction of the IgE Antibody Production by Stimulation of B Cells   

     In 96-well cultivating plate (Sumitomo bakelite) the lymphocytes were inoculated 2×10 5  cells per well, and the compound, anti-human CD 40 antigen (Pharmingen, 2 μg/ml), human recombinant interleukin-4 (IL-4) (Genzyme, 0.1 μg/ml) and human recombinant interleukin-10 (IL-10) (Genzyme, 0.2 μg/ml) were added and cultivated at 37° C. under 5% of CO 2  (0.2 ml!well). After the cultivation for 10 days, the amount of antibody in a supernatant was quantified by ELISA method.
     6) Quantification of the IgE Antibody   

     A commercial kit MESACUP IgE test (Medical &amp; Biological Laboratories Co., Ltd.) was used for the quantification of the IgE. The experiment followed an instruction manual and was carried out in triplicate to calculate the average.
     7) Quantification of the IgG and IgM Antibodies   

     ELISA method was used for the quantification. In 96-well plate (Nunc) 50 μl of 1 μg/ml F(ab′) 2  Goat Anti-human IgG+A+M (H+L) (ZYMED Laboratories) was added and the plate was coated at 4° C. overnight. The,plate was washed twice with 0.05% Tween/PBS (PBST) solution and 100 μl of 0.5% gelatin/PBST was added for blocking at room temperature for 2 hours. After washing three times with PBST, 100 μl of a sample diluted with PBS or 100 μl of human Plasma IgG standard solution or IgM standard solution (BioPur AG, Switzerland) of a pre-determined concentration was added and incubated at room temperature for 1 hour. After washing three times with PBST, 100 μl of a peroxydase-labeled anti-human IgG antibody or anti-human IgM antibody (Southern Biotechnology, Birmingham) which was diluted two thousandth with PBS was added and incubated at room temperature for 1 hour. After washing four times with PBST, 100 μl of a substrate, o-phenylenediamine dihydrochloride, was added for color development. After 30 minutes, the reaction was terminated by addition of 50 μl of 2 N HCl, and the absorption at 492 nm was measured with a microplate reader and the amount of the IgG and IgM was calculated from a standard curve of a standard solution. 
     2. Results 
     The results are shown in  FIGS. 1 and 2 . The compound (1–839) of the present invention has a selective suppressive effect on the IgE antibody production and the intensity was 2,000 times or more of that of the IgG production and 30,000 times or more of that of the IgM. The suppressive effects of the typical compounds on the antibody production are shown in Table 332.  
     
       
         
           
               
               
             
               
                   
                 TABLE 332 
               
             
            
               
                   
                   
               
               
                   
                 IC 50  (ng/ml) 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Compound 
                 IgE 
                 IgG 
                 IgM 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 I-839 
                 &lt;0.00001 
                 0.027 
                 0.37 
               
               
                   
                 I-892 
                 &lt;0.00001 
                 &lt;0.00001 
                 &gt;1 
               
               
                   
                 I-121 
                 &lt;0.0001 
                 &lt;0.0001 
                 &gt;1 
               
               
                   
                 I-988 
                 &lt;0.00001 
                 &lt;0.00001 
                 &gt;1 
               
               
                   
                 I-893 
                 &lt;0.00001 
                 &lt;0.0001 
                 &gt;1 
               
               
                   
                   
               
            
           
         
       
     
     Experiment 6 
     Suppressive Effect on Antibody Production of Mouse Spleen Lymphocytes 
     1. Experimental Method 
     
         
         1) Animals 
       
    
     BALB/c (nu/nu) mice were bought from Japan SLC, Inc. (Shizuoka) and 7 weeks old-male mice were used.
     2) Medium RPMI medium (Nissui Pharmaceutical Co., Ltd.) containing 10% fetal bovine serum (HyClone Lab.) inactivated at 56° C. for 30 minutes, penicillin (100 units/ml) and streptomycin (100 μg/ml) (GIBCO) was used for experiments.   3) Compounds   

     Each of the compounds was dissolved in dimethylsulfoxide (Nakaraitesk) at 2 μg/ml and diluted with the medium to adjust a final concentration to 0.1 pg/ml–10 μg/ml.
     4) Mouse Spleen Lymphocytes   

     A spleen of mouse was taken out and put in a cultivating schale which was filled with Hanks&#39; solution. The spleen was crushed and the cells were pushed out from the organ and filtered through a metal mesh (200 mesh). After the collected cell suspension was washed by centrifugation with sterile Hanks&#39; solution (Nissui Pharmaceutical Co., Ltd.), sterile distilled water was added. After 30 seconds, an equal amount of twice-concentrated Hanks&#39; solution was added for removal of contaminating erythrocytes. The cell suspension, filtered by a nylon mesh and washed by centrifugation, were used as mouse spleen lymphocytes for experiments.
     5) Induction of the IgE Antibody Production by the B Cell Stimulation   

     In 96-well cultivating plate (Sumitomo Bakelite Company Limited) mouse spleen lymphocytes were inoculated 2×10 5  cells per well. The compound of the present invention, lipopolysaccharide (DIFCO Lab., 2 μg/ml) and mouse recombinant interleukin-4 (IL-4) (Genzyme, 50 ng/ml) were added to the well and cultivated at 37° C. under 5% CO 2  (0.2 ml/well). After the cultivation for 10 days, the amount of the antibody in a supernatant was quantified by ELISA method.
     6) Quantification of the IgE Antibody   

     A commercial mouse IgE EIA kit (Yamasa Shoyu Co., Ltd.) was used for the quantification of the IgE. The experiment followed an instruction manual and was carried out in triplicate to calculate the average.
     7) Quantification of the IgG1, IgG2a and IgM Antibodies   

     In 96-well plate 50 μl of 10 μg/ml Goat Anti-Mouse Ig (IgM+G+A, H+L) (Southern Biotechnology, Birmingham) was added and the plate was coated at 4° C. overnight. After the plate was washed twice with a PBST solution, 100 μl of 0.5% gelatin/PBST was added and the plate was blocked at room temperature for 2 hours. After washing three times with PBST, 100 μl of culture supernatant which was diluted with PBS or 100 μl of an antibody standard solution (Mouse IgG1 standard, Mouse IgG2a standard, Mouse IgM standard, BETHYL Laboratories) of a pre-determined concentration was added and incubated for 1 hour. After washing three times with PBST, 100 μl of diluted solution of alkalinephosphatase-labeled anti-mouse IgG1, IgG2a or IgM antibody (Southern Biotechnology, Birmingham) was added and incubated at room temperature for 1 hour. After washing four times with PBST, a substrate, p-nitrophenyl phosphate disodium, was added, and after 30 minutes-incubation period, after 5 N—NaOH was added to stop the reaction. The absorption at 405 nm was measured with a microplate reader, and the amount of the antibody was calculated from the standard curve. For the dilution of the mouse sample and the standard solution was used 10% FCS/PBS. 
     2. Results 
     The results are shown in  FIG. 3 . The figure shows that the compound (I-967) has a suppressive effect on the IgG1, IgG2a and IgM antibodies production only at 1000 ng/ml or more but has a dose-dependent suppressive effect on the IgE production at 0.01 ng/ml or more. In Table 333 the suppressive effects of the representative compounds on the IgE, IgM, IgG1 and IgG2a production are shown. 
     
       
         
           
               
               
               
             
               
                   
                 TABLE 333 
               
             
            
               
                   
                   
               
               
                   
                 IC 50  (ng/ml) 
                   
               
            
           
           
               
               
               
               
               
            
               
                 Compound 
                 IgE 
                 IgG1 
                 IgG2a 
                 IgM 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 I-73 
                 0.044 
                 2600 
                 4900 
                 4200 
               
               
                 I-963 
                 0.00026 
                 510 
                 3600 
                 3500 
               
               
                 I-967 
                 0.1 
                 3500 
                 3600 
                 &gt;10000 
               
               
                   
               
            
           
         
       
     
     Experiment 7 
     Suppressive Effect on Bronchial Inflammatory Cell Infiltration by Inhalation of Antigen 
     1. Experimental Method 
     
         
         1) Animals 
       
    
     BALB/c mice bought from Japan SLC, Inc. (Shizuoka) (female, 8–11 weeks old) were used for experiments.
     2) Sensitizing and Challenge of Antigen   

     For immunizing, 0.2 ml of a suspension of 2 μg of ovalbumin (OVA; Grade V, SIGMA) and 2 mg of aluminium hydroxide gel in physiological saline was intraperitoneally injected. After 2 weeks, 0.2 ml of a solution of 2 μg of OVA in physiological saline was intraperitoneally injected for a booster. After 1 week, each of mice was put in a nebulizing container (an airtight polycarbonate container, 24.5 cm in inner diameter and 20 cm in effective inner height, equipped with 12 cylindrical tubes of 4.8 cm in inner diameter and 12 cm in height) and made inhale a solution of 5% ovalbumin (Grade III, SIGMA) in physiological saline for 20 minutes with an ultrasonic neblizer (Omron Tateisi Elec-Tronics co., NE-U12) for the challenge of antigen.
     3) Administration of the Compound of the Present Invention   

     The compound (I-963) of the present invention was dissolved in N,N-dimethylacetoamide (Nakaraitesk) and diluted one twentieth with miglyol 812 neutral oil (Mitsuba Trading Co., Ltd.) and the solution was orally administered to mice at 40 mg/kg. The administration was continued for 9 days from the booster day to the day before broncho-alveolar lavage.
     4) Broncho-alveolar Lavage (BAL)   

     After 48 hours of the challenge of antigen, the mice were exsanguinated from hearts under ether anesthetic, and the trachea was then cannulated. 0.3 ml of PBS were injected into the lungs and collected, and reinjected four times more (total 1.5 ml).
     5) Measurement of the Total Cell Number in BAL Solution and Classification of Inflammatory Cells   

     After calculation of the total cell number by coloring of a part of BAL solution with Tuirk solution, cells in BAL solution were put on a slide glass with cytospin (SHANDON) for May-Grüwald-Giemsa (MERCK) staining. Under a microscope, 500 cells were classified to a macrophage, an eosinophil, a neutrophil and a lymphocyte and a proportion of each type of the cells was calculated. The number of each type of the cells was calculated by a multiplication of its proportion and the total cell number. 
     2. Results 
     The results are shown in  FIG. 4 . As shown in the figure, the compound (I-963) of the present invention significantly suppresses increasing number of eosinophils and neutrophils by the challenge of antigen. 
     Experiment 8 
     Suppressive Effect on the Cytokine Production of a Mouse T Cell Strain EL-4 
     In 48-well plate were added 2×10 5  mouse T cell strain EL-4 which were suspended in 0.2 ml of 1% fetal bovine serum-added RPMI 1640 medium (2 mM of sodium bicarbonate, 50 units/ml of penicillin, 50 μg/ml of streptomycin and 5×10 −5  M of 2-mercaptoethanol were added) and the compound of the present invention of a pre-determined concentration. TPA was added as a cell stimulater at a final concentration of 10 ng/ml to adjust a final volume of each well to 0.4 ml. Each compound of the present invention was dissolved in DMSO and diluted with the above RPMI 1640 medium, and then for added at a final concentration of 100 ng/ml or less. The cells in the 48-well plate were cultivated in an incubator keeping the humidity 100%, carbon dioxide 5% and air 95% at 37° C. for 24 hours to collect a supernatant of each well. The amount of IL-2, IL-4 and IL-5 released in the medium of each well were measured with the ELISA kit (Amersham K. K.) to be taken as an index of the cytokine production of the cells. TPA free group (-TPA) was used as a control. The results are shown in Table 334. 
     
       
         
           
               
               
             
               
                   
                 TABLE 334 
               
             
            
               
                   
                   
               
               
                   
                 IC 50  (ng/ml) 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Compound 
                 IL-2 
                 IL-4 
                 IL-5 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 I-4 
                 &gt;500 
                 14 
                 120 
               
               
                   
                 I-37 
                 &gt;500 
                 7 
                 110 
               
               
                   
                 I-39 
                 1300 
                 7 
                 130 
               
               
                   
                 I-70 
                 &gt;2000 
                 0.2 
                 1000 
               
               
                   
                 I-73 
                 500 
                 20 
                 15 
               
               
                   
                 I-83 
                 &gt;10000 
                 140 
                 1000 
               
               
                   
                 I-128 
                 &gt;10000 
                 140 
                 450 
               
               
                   
                 I-148 
                 &gt;10000 
                 100 
                 11000 
               
               
                   
                 I-157 
                 &gt;10000 
                 170 
                 &gt;10000 
               
               
                   
                 I-189 
                 &gt;10000 
                 100 
                 10000 
               
               
                   
                 I-190 
                 &gt;100 
                 7 
                 10 
               
               
                   
                 I-202 
                 &gt;2000 
                 &lt;20 
                 &lt;20 
               
               
                   
                 I-209 
                 &gt;200 
                 14 
                 12 
               
               
                   
                 I-213 
                 &gt;1000 
                 25 
                 23 
               
               
                   
                 I-218 
                 &gt;1000 
                 4.8 
                 30 
               
               
                   
                 I-220 
                 &gt;1000 
                 150 
                 720 
               
               
                   
                 I-223 
                 1000 
                 16 
                 45 
               
               
                   
                 I-226 
                 880 
                 17 
                 300 
               
               
                   
                 I-228 
                 &gt;1000 
                 21 
                 30 
               
               
                   
                 I-229 
                 &gt;1000 
                 42 
                 80 
               
               
                   
                 I-230 
                 &gt;1000 
                 13 
                 20 
               
               
                   
                 I-231 
                 &gt;500 
                 9.6 
                 9.2 
               
               
                   
                 I-233 
                 &gt;1000 
                 12 
                 3.8 
               
               
                   
                 I-237 
                 &gt;100 
                 17 
                 100 
               
               
                   
                 I-238 
                 &gt;1000 
                 35 
                 &gt;1000 
               
               
                   
                 I-239 
                 &gt;1000 
                 54 
                 900 
               
               
                   
                 I-242 
                 &gt;1000 
                 100 
                 880 
               
               
                   
                 I-243 
                 &gt;500 
                 63 
                 &gt;550 
               
               
                   
                 I-279 
                 &gt;1000 
                 38 
                 90 
               
               
                   
                 I-282 
                 &gt;500 
                 &lt;5 
                 130 
               
               
                   
                 I-292 
                 &gt;1000 
                 72 
                 600 
               
               
                   
                 I-296 
                 &gt;1000 
                 70 
                 47 
               
               
                   
                 I-301 
                 500 
                 &lt;10 
                 120 
               
               
                   
                 I-302 
                 &gt;1000 
                 25 
                 280 
               
               
                   
                 I-305 
                 &gt;1000 
                 10 
                 340 
               
               
                   
                 I-307 
                 &gt;1000 
                 52 
                 23 
               
               
                   
                 I-309 
                 &gt;500 
                 29 
                 10 
               
               
                   
                 I-318 
                 &gt;1000 
                 68 
                 58 
               
               
                   
                 I-323 
                 &gt;1000 
                 230 
                 24 
               
               
                   
                 I-368 
                 &gt;1000 
                 72 
                 380 
               
               
                   
                 I-375 
                 &gt;1000 
                 200 
                 &gt;1000 
               
               
                   
                 I-379 
                 &gt;1000 
                 88 
                 &gt;1000 
               
               
                   
                 I-386 
                 &gt;1000 
                 68 
                 40 
               
               
                   
                 I-387 
                 &gt;1000 
                 75 
                 40 
               
               
                   
                 I-390 
                 &gt;1000 
                 200 
                 160 
               
               
                   
                 I-392 
                 &gt;1000 
                 50 
                 &gt;1000 
               
               
                   
                 I-395 
                 &gt;1000 
                 1–10 
                 &gt;1000 
               
               
                   
                 I-403 
                 &gt;1000 
                 13 
                 &gt;1000 
               
               
                   
                 I-720 
                 &gt;500 
                 6 
                 110 
               
               
                   
                   
               
            
           
         
       
     
     Formulation Example 1 
     
       
         
           
               
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 The compound of the present invention 
                 15 
                 mg 
               
               
                   
                 Starch 
                 15 
                 mg 
               
               
                   
                 Lactose 
                 15 
                 mg 
               
               
                   
                 Crystalline cellulose 
                 19 
                 mg 
               
               
                   
                 Polyvinyl alcohol 
                 3 
                 mg 
               
               
                   
                 Distilled water 
                 30 
                 ml 
               
               
                   
                 Calcium stearate 
                 3 
                 mg 
               
               
                   
                   
               
            
           
         
       
     
     After all of the above ingredients except for calcium stearate were uniformly mixed, the mixture was crushed and granulated, and dried to obtain a suitable size of granules. After calcium stearate was added to the granules, tablets were formed by compression molding. 
     INDUSTRIAL APPLICABILITY 
     As indicated in the above experiments, the compound of the present invention has a potent immunosuppressive and/or anti-allergic activity. The compound of the present invention and a substance which has the same activity as the compound of the present invention are very useful for a selective suppressor of the IgE production, an immunosuppressive agent and/or an anti-allergic agent.