Patent Publication Number: US-10787708-B2

Title: Method of identifying a gene associated with a disease or pathological condition of the disease

Description:
SEQUENCE LISTING 
     The Sequence Listing file entitled “sequencelisting” having a size of 2,039 bytes and a creation date of 12 Jul. 2017 that was filed with the patent application is incorporated herein by reference in its entirety. 
     TECHNICAL FIELD 
     The present application relates to a method of identifying a gene associated with a disease or its pathological condition. In particular, but not exclusively, the method makes use of exome sequences for the identification. 
     BACKGROUND OF THE INVENTION 
     To date, there are various methods of determining the pathogenic gene form the human genome, for example, by whole-genome sequencing. Whole-exome sequencing (WES) has become a popular means for studying the genetic information, in particular for investigating the disease related genes. However, WES studies are generally susceptible to genotyping errors which may significantly affect the results. 
     Rheumatoid arthritis (RA) is the most common form of systemic autoimmune arthritis with unknown etiology, characterized by systemic inflammation and persistent poly-joint synovitis, principally leading to injury of the flexible joints, often with symptoms of joint pain and swelling, stiffness, bone destruction and fatigue, as well as implications of extra articular organs. The prevalence of RA varies largely in different populations, from 0.25% in Eastern Asians to 0.75% in European ancestry, and to as high as 6% in American Indians. It remains largely unknown whether genetics, cultural, or environmental factors contribute to these differences. During the past years, an increasing list of genetic associations with RA has emerged from genome wide association studies (GWAS), which attributes great relevance to immune system contributed by profound sources of genetic variation with a panel of surface and intracellular signaling molecules as well as cytokines. GWAS has also revealed a complex picture of both shared and population-specific genetic susceptibility loci to this autoimmune disease in comparison of Asian and European populations. Generally, GWASs are designed to capture common genetic variation, and to date, a large portion of the heritability of complex traits has not been explained, which has prompted us to explore other potential sources of genetic susceptibility to RA, such as rare variants. 
     Accordingly, there remains a strong need for an improved method for identifying deleterious and/or pathogenic gene which may be involved in the progression, severity or reoccurrence of a disease, in particular an autoimmune disease highly related to genetic mutations. 
     SUMMARY OF THE INVENTION 
     The present invention provides a method of identifying a gene associated with a disease or pathological condition of the disease, comprising the steps of: 
     a) obtaining a first group of exome sequences from a first population of individuals and a second group of exome sequences from a second population of individuals, wherein the first population of individuals suffer from the disease or pathological condition of the disease, and the second population of individuals do not have the disease or pathological condition of the disease; 
     b) identifying one or more variants in the first group of exome sequences by comparing the first group of exome sequences with the second group of exome sequences, and optionally with a public database, to generate a first set of variant data; 
     c) applying a variant quality score calibration tool with a truth sensitivity threshold to remove false-positive variants having a sensitivity lower than the threshold and background variants from the first set of variant data so as to obtain a second set of variant data; 
     d) removing synonymous variants from the second set of variant data to obtain a third set of variant data; and 
     e) identifying one or more deleterious variants from the third set of variant data using a gene burden analysis, optionally generating a fourth set of variant data. 
     The method of the present invention is exceptionally useful for the determination of deleterious and/or pathogenic gene and for further developments in diagnostic method and treatment methods of the diseases and alleviation of the pathological conditions of the disease. In particular, the method at least improves the genotype accuracy of the results, removes substantial errors resulting from the whole-exome sequencing, and differentiates the rare variants from the common variant efficiently. 
     Those skilled in the art will appreciate that the invention described herein is susceptible to variations and modifications other than those specifically described. The invention includes all such variations and modifications. The invention also includes all steps and features referred to or indicated in the specification, individually or collectively, and any and all combinations of the steps or features. 
     Other features and aspects of the invention will become apparent by consideration of the following detailed description and accompanying drawings. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee. 
         FIGS. 1A and 1B  show the ancestral composition of RA group, i.e. patients suffering from RA, and control group, i.e. people who do not have RA, with Hapmap reference populations. Ten HapMap samples were randomly chosen from each of the three reference populations: CEU, Utah Residents with Northern and Western European Ancestry; CHS, Southern Han Chinese; and YRI, Yoruba in Ibadan, Nigeria.  FIG. 1A  shows the results obtained from Admixture analysis. All of the people in RA group and control group were found to be Chinese ancestry, i.e. having at least 80% (indicated by white horizontal line) Chinese ancestry.  FIG. 1B  shows Dimension 1 and 2 obtained from multidimensional scaling analysis for the RA and control groups. 
         FIGS. 2A and 2B  show the coverage distribution for all exons targeted by enrichment evaluated by inter-quartile range calculation using SPSS 22.0 software.  FIG. 2A  shows that the median coverage for all RA samples was 76-fold, with on average 96% of all targets covered at least 20-fold.  FIG. 2B  shows that the median coverage for all healthy control samples was 68-fold, with on average 94% of all targets covered at least 20-fold. 
         FIG. 3  is a flow chart of whole-exome sequencing for detecting and prioritizing variants conferring susceptibility to rheumatoid arthritis (RA) using variant filtration and gene burden analysis. The variant list for all groups can be found in Table 5. MAF=minor allele frequency in the 1000 Genomes Southern Han Chinese (phase III) population. Pathway analysis in candidate genes identified from 58 RA patients was performed using DAVID 6.8 (https://david.ncifcrf.gov/summary.jsp). 
         FIGS. 4A and 4B  show the sequence alignment of target proteins.  FIG. 4A  refers to the SAA1 (Protein RefSeq: NP_000322.2;  FIG. 4B  refers to SCOT1 (Protein RefSeq: NP_000427.1), each with its template structures used in homolog modeling. Red line represents alpha helix, yellow arrow represents beta sheet, and blue line represents loop region. 
         FIGS. 5A and 5B  show Ramachandran plots for evaluation of protein model.  FIG. 5A  refers to the plot for SAA1, 99.03% of the residues are in the favored region and 0.97% are in the allowed region.  FIG. 5B  refers to the plot for SCOT1, 95.81% of the residues are in the favored region, 3.77% are in the allowed region and only 0.42% are in the disfavored region. Green represents favored region and light-brown represents allowed region. 
         FIGS. 6A, 6B, 6C, and 6D  show the modeled 3D structure comparison of human wild type SAA1 ( FIG. 6A ) and its mutant G90D ( FIG. 6B ), as well as wild type SCOT1 ( FIG. 6C ) and its mutant T58M ( FIG. 6D ). Left panel: the ribbon secondary structure diagram with a helices in red and β sheets in yellow; middle panel: the proposed interactions between mutated residue and its surrounding residues, distances are not represented to scale; right panel: the lipophilic surface representation by showing hydrophilic (magenta), neutral (green) and lipophilic (white). 
         FIG. 7  shows the comparison of X chromosome associated variants distribution between female and male in RA patients. 
     
    
    
     DETAILED DESCRIPTION OF THE EMBODIMENTS 
     Unless otherwise defined, all technical terms used herein have the same meaning as commonly understood by one skilled in the art to which the invention belongs. 
     As used herein, “comprising” means including the following elements but not excluding others. “Essentially consisting of” means that the material consists of the respective element along with usually and unavoidable impurities such as side products and components usually resulting from the respective preparation or method for obtaining the material such as traces of further components or solvents. “Consisting of” means that the material solely consists of, i.e. is formed by the respective element. As used herein, the forms “a,” “an,” and “the,” are intended to include the singular and plural forms unless the context clearly indicates otherwise. 
     The present invention pertains to a method of identifying a gene associated with a disease or pathological condition of the disease. In particular, the disease is an autoimmune disease, a neurodegenerative disease, a cardiovascular disease, a cancer, a gastrointestinal disease, an inflammatory disease, or an endocrine disease. Preferably, the disease is an autoimmune disease. In an embodiment, the disease is rheumatoid arthritis. The expression “pathological condition of the disease” as used herein may refer to any symptoms closely related to the systemic effects of the disease which may be acute or chronic. 
     According to the present invention, the method comprises the steps of: 
     a) obtaining a first group of exome sequences from a first population of individuals and a second group of exome sequences from a second population of individuals, wherein the first population of individuals suffer from the disease or pathological condition of the disease, and the second population of individuals do not have the disease or pathological condition of the disease; 
     b) identifying one or more variants in the first group of exome sequences by comparing the first group of exome sequences with the second group of exome sequences, and optionally with a public database, to generate a first set of variant data; 
     c) applying a variant quality score calibration tool with a truth sensitivity threshold to remove false-positive variants having a sensitivity lower than the threshold and background variants from the first set of variant data so as to obtain a second set of variant data; 
     d) removing synonymous variants from the second set of variant data to obtain a third set of variant data; and 
     e) identifying one or more deleterious variants from the third set of variant data using a gene burden analysis, optionally generating a fourth set of variant data. 
     The term “exome sequence” as used herein refers to a sequence consisting of all expressed genes in a genome, i.e. formed by exons that encode a part of the final mature RNA produced by the gene after introns have been removed by RNA splicing. In the present invention, the exome sequence of the individuals is preferably obtained through whole-exome sequencing. 
     An individual in the present invention is preferably a human or an animal, preferably the individual is a mammal. In an embodiment, the first population of individuals are preferably humans suffering from an autoimmune disease in particular rheumatoid arthritis and are diagnosed according to standard medical criteria. The second population of individuals are humans who do not have the disease, in particular the autoimmune disease, and do not have the associated pathological conditions of the disease. In an embodiment, each of the first and second population of individual has at least 10, 20, 30, 40, or 50 individuals, preferably at least 50 individuals. The first and second population may or may not have the same number of individuals. 
     The step a) of the method may comprise steps of collecting plasma samples from the first and second population of individuals, extracting the DNAs from the plasma samples and performing whole-exome sequencing (WES) to obtain the exome sequence of each of the individuals. Preferably, the first and second exome data are obtained by whole-exome sequencing. It is advantageous to use the WES in the present invention so as to focus on the mutation of gene and/or variant which contributes or likely contributes to the pathogenesis and/or progression of the disease. In particular, it saves lots of efforts and costs in preparing a whole genome and conducting the analysis of the lengthy genome. The person having ordinary skills in the art is aware of suitable methods for performing whole-exome sequencing. 
     In step b) of the method, one or more variants in the first group of exome sequences are identified. The term “variant” as used herein refers to a polynucleotide having a nucleotide sequence different from the reference polynucleotide, i.e. there is a change in the nucleotide sequence compared to the reference one. In this method, the second group of exome sequences act as the reference polynucleotide, optionally normal exome sequences annotated by public accessible database can also provide the reference polynucleotide for the comparison so as to locate and identify the one or more variants present in the first group of exome sequences, i.e. present in the individuals suffering from the disease or the pathological condition of the disease. After the identification, a first set of variant data is obtained and said set of variant data is presented in a computer-readable format. In an embodiment, the first set of variant data is further subject to electronic conversion of format, for instance for subsequent sequence alignment and/or for storage. 
     After obtaining the first set of variant data which shows the differences between the first group of exome sequences with the second group of exome sequences, a variant quality score calibration tool is applied, i.e. step c) of the method. In an embodiment, the step (c) comprises a step (i) of applying the variant quality score calibration tool with the truth sensitivity threshold of about 90% to remove the false-positive variants, and removing the background variants having a read depth of less than 5 and a genotype quality of less than 10 from the first set of variant data. “Variant quality score recalibration tool” (VQSC tool) is preferably applied to improve concordance of sequenced genotype, i.e. remove errors resultant from the whole-exome sequencing. In general, VQSC tool filters variants by using a recalibrated quality score and a sensitivity threshold. In an embodiment herein, the VQSC tool is applied with a truth sensitivity threshold of about 90%, preferably about 95%, more preferably about 99%, to remove the false-positive variants. 
     Also, the background variants having a read depth of less than 5, preferably less than 7.5, more preferably less than 10 and a genotype quality of less than 10, less than 15 or less than 20 are also removed from the first set of variant data. In an embodiment, the background variant having a read depth of less than 10 and a genotype quality of less than 20 are moved. These background variants refer to the variants which may significantly affect the detection of deleterious variants in the later steps and are likely generated by errors or not relevant to the disease. The term “depth of data” (DP) refers to the number of reads passing quality control used to calculate the genotype at a specific site in the sample. A higher value of DP generally denotes a more accurate genotype call. The term “genotype quality” (GQ) refers to a Phred-scaled value representing the confidence that the called genotype is the true genotype. A higher GQ generally denotes a more accurate genotype call. Therefore, by using the variant filtering process of step c), a more accurate set of variant data may be obtained. 
     In an advanced embodiment, the step c) of the method further comprises a step (ii) of screening the resultant variants from step c) (i) based on the dataset provided by UCSC genome browser, in particular based on UCSC genome browser build 37 human reference sequence gene annotation, to keep exonic or slicing variants in the second set of variant data. Alternatively, other accessible dataset showing the already identified variants in human genome may also be applied in combination to better analyze the variants. 
     Next, the second set of variant data is subject to a further variant filter to remove synonymous variants so as to obtain a third set of variant data. Synonymous variants are commonly regarded as benign in their effects towards diseases, in particular less likely to have any effect, and are generally not overexpressed in an individual suffering from a disease or pathological condition. This removal step may be conducted by computer-implemented program and/or in combination with database having annotation of the synonymous variants. 
     In the method of the present invention, a gene burden analysis is conducted to identify one or more deleterious variants from the third set of variant data obtained after step d). The term “deleterious variant” used herein refers to a variant which is consistently appear to cause all reasonable individuals to cause premature death or health problem, i.e. disease, that significantly compromise the capacity of the individual to carry out normal activities. In other words, the deleterious variant is highly related to the disease or pathological condition of the disease. 
     Preferably, the step e) comprises a step (i) of identifying one or more deleterious variants having a gene burden ratio of larger than 1, preferably larger than 1.2 or more preferably larger than 1.5, or being present in the first group of exome sequences in an amount of at least three but absent in the second group of exome sequences. The gene burden ratio is calculated by dividing the allele frequency in the first group of exome sequences by the allele frequency in the reference group, i.e. the second group of exome sequences and optionally an additional control group. 
     In a further embodiment, the step e) further comprises a step (ii) of grouping the identified one or more deleterious variants having a minor allele frequency less than or equal to about 0.02, preferably less than or equal to 0.015, less than or equal to 0.01, most preferably less than 0.01, into a rare variant group, and grouping the rest of the identified one or more deleterious variants into a common variant group. Minor allele frequency (MAF) generally refers to the frequency at which the second most common allele occurs in a given population. The identification of rare and common variants helps to investigate the genetic susceptibility of the individual to the disease. 
     The method may further comprises a step f), after step e), of determining a pathogenic gene associated with the disease or pathological condition of the disease from the fourth set of variant data by using a logistic regression model and public accessible database. The term “pathogenic gene” refers to a gene that contributes or likely contributes to the pathogenesis and progression of the disease. 
     In a further embodiment, the method further comprises a biological pathway analysis to determine the functional role of the identified one or more deleterious variants in the onset, progression, severity or recurrence of the disease. In particular, a structural analysis may be performed by using a homology model for 3D determination of the associated protein. 
     In order to improve the accuracy of the identification, the method further comprises a step of confirming the ethnicity of the first and second population of individuals via ancestry composition analysis. 
     Accordingly, the present invention provides an improved approach for the identification of deleterious and/or pathogenic variants involved in the disease onset, progression, severity or recurrence of a disease. The comprehensive method as disclosed herein at least improves the genotype accuracy of the results, removes substantial errors resulting from the whole-exome sequencing, and differentiates the rare variants from the common variant efficiently. The application of whole-exome sequencing also saves lots of efforts in preparing whole-genome which may contain substantial irrelevant genetic information of the disease, and of course less labor intensive. 
     The method of the present invention is exceptionally useful for the determination of deleterious and/or pathogenic gene for further developments in diagnostic method and treatment methods of the diseases and alleviation of the pathological conditions of the disease. 
     EXAMPLES 
     Example 1 
     Sample Collections 
     1. Patients 
     58 patients diagnosed as having RA were unrelated individuals of Han Chinese descent recruited from hospitals in Southern and Eastern China (Guangzhou and Changzhou) using 2010 Rheumatoid Arthritis Classification Criteria established by American College of Rheumatology and European League Against Rheumatism Collaborative Initiative (2010 ACR/EULAR). 
     In addition, 66 healthy and unrelated blood donors of Han Chinese ancestry from Medical Center for Physical Examination and Health Assessment, were included as controls. 
     Detailed descriptions of sequenced individuals and clinical characteristics of the enrolled patients are provided in Table 1 and 2. Written informed consent was obtained from all of the participants, and the study was registered in Chinese Clinical Trial Registry (ChiCTR-ROC-17010351) and approved by the local ethics committees of Macau University of Science and Technology (Macau, China). 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Basic information of the 124 sequenced individuals 
               
            
           
           
               
               
               
               
            
               
                   
                 Parameter 
                 Cases 
                 Controls 
               
               
                   
                   
               
               
                   
                 n 
                 58 
                 66 
               
               
                   
                 Sex 
                 43 female, 15 male 
                 41 female, 25 male 
               
               
                   
                 Age 
                 48.48 ± 14.08 
                 35.23 ± 10.73 
               
               
                   
                   
               
            
           
         
       
     
                     TABLE 2               Demographic and clinical characteristics of the 58 patients with RA                                        Women/men, no. (%)   43 (74.1%)/15 (25.9%)       Age at diagnosis, mean ± SD years       All   45.17 ± 14.13       Women   43.67 ± 12.67       Men   49.47 ± 17.46       Disease duration (years), mean ± SD   3.31 ± 4.29       ≤1 Year   26       ≥3 Year   23       Rheumatoid factor +/−, no. (%)   49 (87.5%)/7 (12.5%); 2 Not Test       No. of tender joints, mean ± SD   7.00 ± 7.36       No. of swollen joints, mean ± SD   3.43 ± 4.53       CRP(mg/l)   19.46 ± 22.62       ESR(mm/h)   40.38 ± 30.48               CRP: C-reactive protein; ESR: Erythrocyte Sedimentation Rate.            
2. Confirmation of the Ethnicity of the RA and Control Groups
 
     The ethnicity of the patients suffering from RA, i.e. RA group, and the healthy control group was verified by conducting ancestry composition analysis using admixture v1.3.0 (https://www.genetics.ucla.edu/software/admixture) and multidimensional scaling in PLINK v1.07 (http://zzz.bwh.harvard.edu//plink/). The results are shown in  FIG. 1 . Three ethnic populations were used as reference samples from 1000 Genome Project Phase III data (http://ftp.1000genomes.ebi.ac.uk/vol1/ftp/release/20130502/ALL.chr9.phase3_shapeit2_mvncall_integrated_v5a.20130502.genotypes.vcf.gz), including Utah Residents with Northern and Western European Ancestry (EUR-CEU), Yoruba in Ibadan, Nigeria (AFR-YRI) and Southern Han Chinese (EAS-CHS). 
     3. Preparation of the Samples for Gene Sequencing 
     Blood samples were collected from the patients of the RA group and the healthy people from the control group, according to protocols approved by local institutional review boards. Genomic DNA was extracted from peripheral blood mononuclear cells (PBMCs) using PureLink® Genomic DNA Mini Kit (Invitrogen, USA) according to the manufacturer&#39;s protocol. 500 ng of double-stranded DNA was determined by Qubit (Invitrogen, USA) and randomly fragmented to 150-200 bp with Covaris cracker (Covaris, USA). Fragments with specific indexes were hybridized with probes. After PCR amplification and quality control, libraries were sequenced by next-generation sequencing. Agilent liquid phase hybridization was applied to efficiently enrich whole exons which would be sequenced on Illumina platform. Agilent SureSelect Human All ExonV5/V6 (Agilent Technologies, USA) with reagents were used for sequencing libraries and capture, which was recommended by the instruction manual and followed by optimized experimental procedures. 
     Sequencing was performed on an Illumina HiSeq X sequencer with a paired-end read length of 150 bp in the Genomics Core Facility at Novogene (Genome Sequencing Company, Beijing, China). Data generated in this study will be submitted to the National Center for Biotechnology Information (NCBI) BioProject. 
     Example 2 
     Preparation of a List of Candidate Genes Associated with Rheumatoid Arthritis 
     A list of 159 candidate RA-associated genetic variants reported by previous genome wide association studies (GWAS) with the P value threshold of P&lt;1×10 −5 , as shown in Table 3, was prepared based on Rheumatoid Arthritis associated genes in the NHGRI GWAS Catalog (Welter D et al., Nucleic acids research 2014; 42:D1001-D1006) and literatures (Freudenberg J et al., Arthritis Rheumatol 2014; 66:1121-1132; Manolio T A et al., Nature 2009; 461:747-753; Okada Y et al., Nature 2014; 506:376-381; and Diogo D et al., The American Journal of Human Genetics 2013; 92:15-27). 
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 A list of candidate genes having high priority in RA 
               
            
           
           
               
               
               
               
               
            
               
                 Gene 
                 SNP 
                 p-Value 
                 Odd ratio 
                 References 
               
               
                   
               
               
                 ABHD6 
                 rs73081554 
                 5.00E−08 
                 1.18 
                 Okada Y, PMID: 24390342 
               
               
                 ACOXL 
                 rs6732565 
                 3.00E−08 
                 1.07 
                 Okada Y, PMID: 24390342 
               
               
                 AFF3 
                 rs9653442| 
                  1.00E−14| 
                 1.12|1.12| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs11676922| 
                  1.00E−14| 
                 1.12 
                 E A, PMID: 20453842|Jiang 
               
               
                   
                 rs10865035 
                  2.00E−08| 
                   
                 L, PMID: 24782177|Stahl 
               
               
                   
                   
                 2.00E−06 
                   
                 E A, PMID: 20453842 
               
               
                 AHNAK2 
                 rs2582532 
                 3.00E−07 
                 1.17 
                 Okada Y, PMID: 24390342 
               
               
                 AIRE 
                 rs2075876| 
                  4.00E−09| 
                 1.18|1.16 
                 Terao C, PMID: 21505073|Terao 
               
               
                   
                 rs760426 
                 4.40E−08 
                   
                 C, PMID: 21505073 
               
               
                 ANAPC4 
                 rs3816587 
                 9.00E−06 
                 1.09 
                 WTCCC, PMID: 17554300 
               
               
                 ANKRD55 
                 rs77331626| 
                  7.00E−24| 
                 1.21|1.21| 
                 Okada Y, PMID: 24390342|Okada 
               
               
                   
                 rs7731626| 
                  8.00E−23| 
                 1.28 
                 Y, PMID: 24390342|Stahl 
               
               
                   
                 rs6859219 
                 1.00E−11 
                   
                 E A, PMID: 20453842 
               
               
                 ANXA3 
                 rs2867461 
                 1.00E−12 
                 1.13 
                 Okada Y, PMID: 22446963 
               
               
                 APOM 
                 rs805297 
                 3.00E−10 
                 1.56 
                 Hu H J, PMID: 21844665 
               
               
                 ARAP1 
                 rs3781913 
                 6.00E−10 
                 1.12 
                 Okada Y, PMID: 22446963 
               
               
                 ARHGEF3 
                 rs2062583 
                 2.16E−06 
                 0.63 
                 Freudenberg J, PMID: 21452313 
               
               
                 ARID5B 
                 rs71508903| 
                  1.00E−08| 
                 1.18|1.18| 
                 Okada Y, PMID: 24390342|Okada 
               
               
                   
                 rs71508903| 
                  1.00E−08| 
                 1.16 
                 Y, PMID: 24390342|Okada 
               
               
                   
                 rs10821944 
                 6.00E−18 
                   
                 Y, PMID: 22446963 
               
               
                 ARL15 
                 rs255758 
                 7.00E−06 
                 1.42 
                 Negi S, PMID: 23918589 
               
               
                 ATG5 
                 rs9372120 
                 4.00E−08 
                 1.10 
                 Okada Y, PMID: 24390342 
               
               
                 ATM 
                 chr11: 107967350 
                 1.00E−08 
                 1.21 
                 Okada Y, PMID: 24390342 
               
               
                 B3GNT2 
                 rs13385025| 
                  9.00E−07| 
                 1.11|1.11 
                 Okada Y, PMID: 24390342|Okada 
               
               
                   
                 rs11900673 
                 1.00E−08 
                   
                 Y, PMID: 22446963 
               
               
                 BATF 
                 rs7155603 
                 1.00E−07 
                 1.16 
                 Stahl E A, PMID: 20453842 
               
               
                   
                   
                   
                   
                 Okada Y, PMID: 
               
               
                 BLK 
                 rs2736337| 
                  2.00E−07| 
                 1.15|0.77| 
                 24390342|Freudenberg J, PMID: 
               
               
                   
                 rs1600249| 
                  5.00E−06| 
                 1.29|1.19 
                 21452313|Freudenberg J, PMID: 
               
               
                   
                 rs2736340 
                  1.22E−05| 
                   
                 21452313|Gregersen P K, PMID: 
               
               
                   
                   
                 6.00E−09 
                   
                 19503088 
               
               
                 BTNL2 
                 rs3763309 
                  2.00E−124 
                 2.30 
                 Orozco G, PMID: 24449572 
               
               
                 C1QBP 
                 rs72634030 
                 2.00E−09 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 C4orf52 
                 rs11933540 
                 1.00E−16 
                 1.15 
                 Okada Y, PMID: 24390342 
               
               
                 C5 
                 rs10985070| 
                  4.00E−09| 
                 1.09|1.13| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs3761847| 
                  2.00E−07| 
                 NR 
                 E A, PMID: 20453842|Gregersen 
               
               
                   
                 rs881375 
                 4.00E−08 
                   
                 P K, PMID: 19503088 
               
               
                 C5orf30 
                 rs2561477| 
                  1.00E−10| 
                 1.09|1.14 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs26232 
                 4.00E−08 
                   
                 E A, PMID: 20453842 
               
               
                 C6orf10 
                 rs9275406 
                 3.00E−12 
                 2.10 
                 Negi S, PMID: 23918589 
               
               
                 CASP8 
                 rs6715284 
                 2.00E−09 
                 1.15 
                 Okada Y, PMID: 24390342 
               
               
                 CCL19 
                 rs11574914 
                 2.00E−15 
                 1.13 
                 Okada Y, PMID: 24390342 
               
               
                 CCL21 
                 rs951005| 
                  4.00E−10| 
                 1.19|1.12| 
                 Stahl E A, PMID: 
               
               
                   
                 rs2812378| 
                  3.00E−08| 
                 1.13 
                 20453842|Raychaudhuri 
               
               
                   
                 rs11574914 
                 2.00E−15 
                   
                 S, PMID: 18794853|Okada 
               
               
                   
                   
                   
                   
                 Y, PMID: 24390342 
               
               
                 CCR6 
                 rs1571878| 
                  1.00E−22| 
                 1.28|1.13| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs3093023| 
                  2.00E−11| 
                 NR|NR 
                 E A, PMID: 20453842|Jiang 
               
               
                   
                 rs1854853| 
                  4.00E−09| 
                   
                 L, PMID: 24782177|Jiang 
               
               
                   
                 rs3093024 
                  2.00E−10| 
                   
                 L, PMID: 24782177|Kochi 
               
               
                   
                   
                 8.00E−19 
                   
                 Y, PMID: 20453841 
               
               
                 CD2 
                 rs624988 
                 8.00E−10 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 CD226 
                 rs2469434 
                 1.00E−08 
                 NR 
                 Okada Y, PMID: 24390342 
               
               
                 CD244 
                 rs11265493| 
                  4.10E−07| 
                 1.28|1.3| 
                 Suzuki A, PMID: 
               
               
                   
                 rs3753389| 
                  8.00E−08| 
                 1.31|1.28| 
                 18794858|Suzuki A, PMID: 
               
               
                   
                 rs3766379| 
                  3.00E−08| 
                 1.31 
                 18794858|Suzuki A, PMID: 
               
               
                   
                 rs1319651| 
                  6.40E−07| 
                   
                 18794858|Suzuki A, PMID: 
               
               
                   
                 rs6682654 
                 7.00E−08 
                   
                 18794858|Suzuki A, PMID: 
               
               
                   
                   
                   
                   
                 18794858 
               
               
                 CD247 
                 rs840016 
                 2.00E−06 
                 1.11 
                 Stahl E A, PMID: 20453842 
               
               
                 CD28 
                 rs1980422 
                 2.00E−13 
                 1.13 
                 Okada Y, PMID: 24390342 
               
               
                 CD40 
                 rs4239702| 
                  1.00E−16| 
                 1.14|0.85| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs4810485 
                  3.00E−09| 
                 1.15 
                 E A, PMID: 
               
               
                   
                   
                 8.00E−09 
                   
                 20453842|Raychaudhuri 
               
               
                   
                   
                   
                   
                 S, PMID: 18794853 
               
               
                 CD5 
                 rs508970 
                 3.00E−06 
                 1.07 
                 Okada Y, PMID: 24390342 
               
               
                 CD83 
                 chr6: 14103212| 
                  3.00E−06| 
                 1.16|1.14 
                 Okada Y, PMID: 
               
               
                   
                 rs12529514 
                 2.00E−08 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 CDK2 
                 rs773125 
                 1.00E−10 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 CDK4 
                 rs1633360 
                 1.00E−07 
                 1.07 
                 Okada Y, PMID: 24390342 
               
               
                 CDK5RAP2 
                 rs12379034 
                 1.00E−12 
                 1.34 
                 Jiang L, PMID: 24782177 
               
               
                 CDK6 
                 rs4272|rs42041 
                  1.00E−08| 
                 1.10|1.11 
                 Okada Y, PMID: 
               
               
                   
                   
                 4.00E−06 
                   
                 24390342|Raychaudhuri 
               
               
                   
                   
                   
                   
                 S, PMID: 18794853 
               
               
                 CEP57 
                 rs4409785 
                 1.00E−11 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 CFLAR 
                 rs6715284 
                 2.00E−09 
                 1.15 
                 Okada Y, PMID: 24390342 
               
               
                 CLNK 
                 rs13142500 
                 2.00E−06 
                 1.10 
                 Okada Y, PMID: 24390342 
               
               
                 CLYBL 
                 rs9557321 
                 6.00E−08 
                 1.73 
                 Bossini-Castillo L, PMID: 
               
               
                   
                   
                   
                   
                 24532677 
               
               
                 COG6 
                 rs9603616 
                 2.00E−12 
                 1.10 
                 Okada Y, PMID: 24390342 
               
               
                 CSF2 
                 rs657075| 
                  6.00E−06| 
                 1.12|1.12 
                 Okada Y, PMID: 
               
               
                   
                 rs657075 
                 3.00E−10 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 CSF3 
                 chr17: 38031857 
                 2.00E−12 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 CTLA4 
                 rs3087243| 
                  3.00E−25| 
                 1.14|1.15| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs3087243| 
                  1.00E−08| 
                 1.09|NR 
                 E A, PMID: 20453842|Doroth??e 
               
               
                   
                 rs231775| 
                  6.30E−07| 
                   
                 Diogo, PMID: 23261300|Gregersen 
               
               
                   
                 rs231735 
                 6.00E−09 
                   
                 P K, PMID: 19503088 
               
               
                 CXCR5 
                 rs10790268 
                 1.00E−15 
                 1.14 
                 Okada Y, PMID: 24390342 
               
               
                 DNASE1L3 
                 rs73081554 
                 5.00E−08 
                 1.18 
                 Okada Y, PMID: 24390342 
               
               
                 DPP4 
                 rs12617656 
                 1.00E−08 
                 1.24 
                 Jiang L, PMID: 24782177 
               
               
                 EOMES 
                 rs3806624 
                 3.00E−08 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 ETS1 
                 rs73013527| 
                  1.00E−06| 
                 1.08|1.09 
                 Okada Y, PMID: 
               
               
                   
                 rs4937362 
                 8.00E−07 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 ETV7 
                 rs2234067 
                 1.60E−09 
                 1.15 
                 Okada Y, PMID: 24390342 
               
               
                 FADS1 
                 rs968567 
                 2.00E−08 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 FADS2 
                 rs968567 
                 2.00E−08 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 FADS3 
                 rs968567 
                 2.00E−08 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 FAM124A 
                 rs3790022 
                 1.00E−06 
                 1.49 
                 Bossini-Castillo L, PMID: 
               
               
                   
                   
                   
                   
                 24532677 
               
               
                 FCGR2A 
                 rs72717009| 
                  1.00E−07| 
                 1.13|1.10| 
                 Okada Y, PMID: 
               
               
                   
                 rs1801274| 
                  2.40E−07| 
                 1.14 
                 24390342|Doroth??e 
               
               
                   
                 rs11810143 
                 1.80E−07 
                   
                 Diogo, PMID: 23261300|Doroth??e 
               
               
                   
                   
                   
                   
                 Diogo, PMID: 23261300 
               
               
                 FCRL3 
                 rs2317230 
                 2.00E−07 
                 1.07 
                 Okada Y, PMID: 24390342 
               
               
                 FLI1 
                 rs4937362 
                 8.00E−07 
                 1.09 
                 Okada Y, PMID: 22446963 
               
               
                 GATA3 
                 rs3824660 
                 2.00E−08 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 GATSL3 
                 rs1043099 
                 7.00E−09 
                 1.19 
                 Orozco G, PMID: 24449572 
               
               
                 GCH1 
                 rs3783637 
                 2.00E−06 
                 1.10 
                 Okada Y, PMID: 22446963 
               
               
                 GMCL1L 
                 rs2961663 
                 4.00E−06 
                 NR 
                 Padyukov L, PMID: 21156761 
               
               
                 GPR125 
                 rs6448119 
                 7.00E−06 
                 NR 
                 Padyukov L, PMID: 21156761 
               
               
                 GRHL2 
                 rs678347 
                 2.00E−08 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 GRM5 
                 rs518167 
                 2.00E−06 
                 2.24 
                 Bossini-Castillo L, PMID: 
               
               
                   
                   
                   
                   
                 24532677 
               
               
                 HLA 
                 rs12194148| 
                  5.00E−58| 
                 NR|NR 
                 Padyukov L, PMID: 
               
               
                   
                 rs2157337 
                 9.00E−52 
                   
                 21156761|Padyukov L, PMID: 
               
               
                   
                   
                   
                   
                 21156761 
               
               
                 HLA-B 
                 rs2596565 
                 9.00E−09 
                 1.40 
                 Bossini-Castillo L, PMID: 
               
               
                   
                   
                   
                   
                 24532677 
               
               
                 HLA-DQA1 
                 rs9271348| 
                  5.00E−07| 
                 1.28|NR| 
                 Bossini-Castillo L, PMID: 
               
               
                   
                 rs6457617| 
                  1.00E−09| 
                 2.10 
                 24532677|Julia A, PMID: 
               
               
                   
                 rs9275406 
                 3.00E−12 
                   
                 18668548|Negi S, PMID: 
               
               
                   
                   
                   
                   
                 23918589 
               
               
                 HLA-DQA2 
                 rs12525220| 
                  2.00E−13| 
                 2.87|NR| 
                 Jiang L, PMID: 24782177|Julia 
               
               
                   
                 rs6457617| 
                  1.00E−09| 
                 2.10 
                 A, PMID: 18668548|Negi 
               
               
                   
                 rs9275406 
                 3.00E−12 
                   
                 S, PMID: 23918589 
               
               
                 HLA-DQB1 
                 rs12525220| 
                  2.00E−13| 
                 2.87|2.10 
                 Jiang L, PMID: 24782177|Negi 
               
               
                   
                 rs9275406 
                 3.00E−12 
                   
                 S, PMID: 23918589 
               
               
                 HLA-DRB1 
                 rs9268839| 
                     1.00E−250| 
                 2.47|2.47| 
                 Okada Y, PMID: 
               
               
                   
                 rs9268839| 
                     1.00E−250| 
                 2.88|2.51| 
                 24390342|Okada Y, PMID: 
               
               
                   
                 rs6910071| 
                     1.00E−299| 
                 NR|3.62| 
                 24390342|Stahl E A, PMID: 
               
               
                   
                 rs7765379| 
                  5.00E−23| 
                 2.55|NR| 
                 20453842|Freudenberg J, PMID: 
               
               
                   
                 rs13192471| 
                  2.00E−58| 
                 1.28 
                 21452313|Kochi Y, PMID: 
               
               
                   
                 rs660895| 
                     1.00E−108| 
                   
                 20453841|Plenge R M, PMID: 
               
               
                   
                 rs6457620| 
                     4.00E−186| 
                   
                 17804836|Raychaudhuri 
               
               
                   
                 rs615672| 
                  8.00E−27| 
                   
                 S, PMID: 18794853|WTCCC, 
               
               
                   
                 rs9271348 
                 5.00E−07 
                   
                 PMID: 17554300|Bossini- 
               
               
                   
                   
                   
                   
                 Castillo L, PMID: 24532677 
               
               
                 IFNGR2 
                 rs73194058 
                 1.00E−06 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 IGFBP1 
                 rs6956740 
                 5.00E−07 
                 NR 
                 Padyukov L, PMID: 21156761 
               
               
                 IKZF3 
                 chr17: 38031857| 
                  2.00E−12| 
                 1.09|1.10 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs2872507 
                 9.00E−07 
                   
                 E A, PMID: 20453842 
               
               
                 IL2 
                 rs45475795| 
                  4.00E−06| 
                 1.14|1.12 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs13119723 
                 7.00E−07 
                   
                 E A, PMID: 20453842 
               
               
                 IL20RB 
                 rs9826828 
                 9.00E−10 
                 1.44 
                 Okada Y, PMID: 24390342 
               
               
                 IL21 
                 rs45475795| 
                  4.00E−06| 
                 1.14|1.12 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs13119723 
                 7.00E−07 
                   
                 E A, PMID: 20453842 
               
               
                 IL2RA 
                 rs706778| 
                  5.00E−14| 
                 1.10|1.14| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs706778| 
                  1.00E−11| 
                 1.25|1.19 
                 E A, PMID: 20453842|Doroth??e 
               
               
                   
                 rs2228150| 
                  6.60E−06| 
                   
                 Diogo, PMID: 23261300|Orozco 
               
               
                   
                 rs2104286 
                 1.00E−06 
                   
                 G, PMID: 24449572 
               
               
                 IL2RB 
                 rs3218251 
                 6.00E−06 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 IL3 
                 rs657075 
                 6.00E−06 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 IL6R 
                 rs2228145 
                 4.00E−09 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 IL6ST 
                 rs6859219 
                 1.00E−11 
                 1.28 
                 Stahl E A, PMID: 20453842 
               
               
                 INPP5B 
                 rs28411352 
                 3.00E−12 
                 1.11 
                 Okada Y, PMID: 24390342 
               
               
                 intergenic 
                 rs12413578 
                 5.00E−08 
                 NR 
                 Okada Y, PMID: 24390342 
               
               
                 IRAK1 
                 rs5987194 
                 3.00E−12 
                 1.16 
                 Okada Y, PMID: 24390342 
               
               
                 IRF4 
                 rs9378815 
                 1.00E−07 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 IRF5 
                 chr7: 128580042| 
                  1.00E−14| 
                 1.12|1.19| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs10488631| 
                  4.00E−11| 
                 1.44 
                 E A, PMID: 20453842|Padyukov 
               
               
                   
                 rs3807306 
                 3.00E−07 
                   
                 L, PMID: 21156761 
               
               
                 IRF8 
                 rs13330176| 
                  1.00E−12| 
                 1.12|1.12 
                 Okada Y, PMID: 
               
               
                   
                 rs2280381 
                 2.00E−06 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 JAZF1 
                 rs67250450 
                 3.00E−09 
                 1.11 
                 Okada Y, PMID: 24390342 
               
               
                 KCNIP4 
                 rs6448119 
                 7.00E−06 
                 NR 
                 Padyukov L, PMID: 21156761 
               
               
                 KIF3 
                 rs17374222 
                 2.00E−06 
                 1.13 
                 Stahl E A, PMID: 20453842 
               
               
                 KIF5A 
                 rs1678542| 
                  1.00E−07| 
                 1.20|1.12 
                 Orozco G, PMID: 
               
               
                   
                 rs1678542 
                 9.00E−08 
                   
                 24449572|Raychaudhuri 
               
               
                   
                   
                   
                   
                 S, PMID: 18794853 
               
               
                 LBH 
                 rs10175798 
                 1.00E−09 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 LOC100506023 
                 rs2105325 
                 3.00E−11 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 LOC100506403 
                 rs8133843 
                 2.00E−08 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 LOC145837 
                 rs8026898 
                 4.00E−19 
                 1.15 
                 Okada Y, PMID: 24390342 
               
               
                 LOC339442 
                 rs12140275 
                 2.00E−09 
                 1.11 
                 Okada Y, PMID: 24390342 
               
               
                 MED1 
                 rs1877030 
                 2.00E−08 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 MHC 
                 rs7748270| 
                  1.00E−16| 
                 2.01|2.36| 
                 Jiang L, PMID: 
               
               
                   
                 rs6457617| 
                  5.00E−75| 
                 2.87 
                 24782177|WTCCC, PMID: 
               
               
                   
                 rs12525220 
                 2.00E−13 
                   
                 17554300|Jiang L, PMID: 
               
               
                   
                   
                   
                   
                 24782177 
               
               
                 MICA 
                 rs2596565 
                 9.00E−09 
                 1.40 
                 Bossini-Castillo L, PMID: 
               
               
                   
                   
                   
                   
                 24532677 
               
               
                 MMEL1 
                 chr1: 2523811| 
                  5.00E−09| 
                 1.10|1.12 
                 Okada Y, PMID: 
               
               
                   
                 rs3890745 
                 1.00E−07 
                   
                 24390342|Raychaudhuri 
               
               
                   
                   
                   
                   
                 S, PMID: 18794853 
               
               
                 MTF1 
                 rs28411352 
                 3.00E−12 
                 1.11 
                 Okada Y, PMID: 24390342 
               
               
                 NFKBIE 
                 rs2233424| 
                  1.00E−19| 
                 1.26|1.19 
                 Okada Y, PMID: 
               
               
                   
                 rs2233434 
                  6.00E−19| 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                 1.00E−15 
                   
                 22446963|Myouzen K, PMID: 
               
               
                   
                   
                   
                   
                 23028356 
               
               
                 OLIG3 
                 rs2230926| 
                  2.00E−06| 
                 1.31|1.22| 
                 Kochi Y, PMID: 20453841EA|Plenge 
               
               
                   
                 rs6920220| 
                  1.00E−07| 
                 1.33 
                 R M, PMID: 17982456|Plenge 
               
               
                   
                 rs10499194 
                 1.00E−09 
                   
                 R M, PMID: 17982456 
               
               
                 P2RY10 
                 chrX: 78464616 
                 4.00E−08 
                 1.11 
                 Okada Y, PMID: 24390342 
               
               
                 PADI4 
                 rs2301888| 
                  1.00E−18| 
                 1.13|1.50 
                 Okada Y, PMID: 
               
               
                   
                 rs2240335 
                 2.00E−08 
                   
                 24390342|Freudenberg J, PMID: 
               
               
                   
                   
                   
                   
                 21452313 
               
               
                 PDE2A 
                 rs3781913 
                 6.00E−10 
                 1.12 
                 Okada Y, PMID: 22446963 
               
               
                 PIP4K2C 
                 rs1678542 
                 9.00E−08 
                 1.12 
                 Raychaudhuri S, PMID: 
               
               
                   
                   
                   
                   
                 18794853 
               
               
                 PLCL2 
                 rs4452313 
                 2.00E−10 
                 NR 
                 Okada Y, PMID: 24390342 
               
               
                 PLD4 
                 rs2582532| 
                  3.00E−07| 
                 1.17|1.15 
                 Okada Y, PMID: 
               
               
                   
                 rs2841277 
                 2.00E−14 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 POU3F1 
                 rs12131057 
                 4.00E−07 
                 1.16 
                 Stahl E A, PMID: 20453842 
               
               
                 PPIL4 
                 rs9373594 
                 3.00E−09 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 PRKCB1 
                 rs7404928 
                 4.00E−06 
                 1.08 
                 Okada Y, PMID: 22446963 
               
               
                 PRKCH 
                 rs3783782| 
                  2.00E−09| 
                 1.14|1.09 
                 Okada Y, PMID: 
               
               
                   
                 rs1957895 
                 4.00E−07 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 PRKCQ 
                 rs947474| 
                  3.00E−10| 
                 1.12|1.15| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs4750316 
                  2.00E−06| 
                 1.14 
                 E A, PMID: 
               
               
                   
                   
                 4.00E−06 
                   
                 20453842|Raychaudhuri 
               
               
                   
                   
                   
                   
                 S, PMID: 18794853 
               
               
                 PTPN11 
                 rs10774624 
                 7.00E−09 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 PTPN2 
                 rs8083786| 
                  2.00E−11| 
                 1.18|1.10 
                 Okada Y, PMID: 
               
               
                   
                 rs2847297 
                 2.00E−08 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 PTPN22 
                 rs2476601| 
                     9.00E−170| 
                 1.80|1.94| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs2476601| 
                  9.00E−74|0| 
                 1.82|1.79| 
                 E A, PMID: 20453842|Doroth??e 
               
               
                   
                 rs6679677 
                  1.00E−08| 
                 1.98 
                 Diogo, PMID: 23261300|Padyukov 
               
               
                   
                   
                  6.00E−42| 
                   
                 L, PMID: 21156761|Raychaudhuri 
               
               
                   
                   
                 6.00E−25 
                   
                 S, PMID: 18794853|WTCCC, 
               
               
                   
                   
                   
                   
                 PMID: 17554300 
               
               
                 PVT1 
                 rs1516971 
                 1.00E−10 
                 1.15 
                 Okada Y, PMID: 24390342 
               
               
                 PXK 
                 rs73081554| 
                  5.00E−08| 
                 1.18|1.29 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs13315591 
                 5.00E−08 
                   
                 E A, PMID: 20453842 
               
               
                 RAD51B 
                 rs1950897 
                 5.00E−08 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 RAG1 
                 rs331463 
                 1.00E−07 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 RAG2 
                 rs331463 
                 1.00E−07 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 RASGRP1 
                 rs8032939 
                 2.00E−18 
                 1.13 
                 Okada Y, PMID: 24390342 
               
               
                 RBPJ 
                 rs874040| 
                  1.00E−16| 
                 1.14|1.19 
                 Stahl E A, PMID: 
               
               
                   
                 rs6448432 
                 4.00E−07 
                   
                 20453842|Orozco G, PMID: 
               
               
                   
                   
                   
                   
                 24449572 
               
               
                 RCAN1 
                 chr21: 35928240 
                 3.00E−07 
                 1.11 
                 Okada Y, PMID: 24390342 
               
               
                 REL 
                 rs34695944| 
                  2.00E−15| 
                 1.12|1.13| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs13031237| 
                  8.00E−07| 
                 NR 
                 E A, PMID: 20453842|Gregersen 
               
               
                   
                 rs13017599 
                 2.00E−12 
                   
                 P K, PMID: 19503088 
               
               
                 RNASEH2B 
                 rs3790022 
                 1.00E−06 
                  1.4925 
                 Bossini-Castillo L, PMID: 
               
               
                   
                   
                   
                   
                 24532677 
               
               
                 RPS12P4 
                 rs4305317 
                 2.00E−06 
                 1.45 
                 Padyukov L, PMID: 21156761 
               
               
                 RTKN2 
                 rs6479800| 
                  4.00E−06| 
                 1.19|NR 
                 Okada Y, PMID: 
               
               
                   
                 rs3125734 
                 5.00E−09 
                   
                 24390342|Myouzen K, 
               
               
                   
                   
                   
                   
                 PMID: 
               
               
                   
                   
                   
                   
                 23028356 
               
               
                 RUNX1 
                 rs8133843 
                 2.00E−08 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 SALL3 
                 rs2002842 
                 6.00E−06 
                 1.61 
                 Julia A, PMID: 18668548 
               
               
                 SFTPD 
                 rs726288 
                 9.00E−09 
                 1.22 
                 Okada Y, PMID: 24390342 
               
               
                 SH2B3 
                 rs10774624| 
                  7.00E−09| 
                 1.09|1.08 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs3184504 
                 6.00E−06 
                   
                 E A, PMID: 20453842 
               
               
                 SMIM21 
                 rs1943199 
                 2.00E−08 
                 1.94 
                 Bossini-Castillo L, PMID: 
               
               
                   
                   
                   
                   
                 24532677 
               
               
                 SPRED2 
                 rs1858037| 
                  1.00E−08| 
                 1.19|1.13 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs934734 
                  5.00E−10| 
                   
                 E A, PMID: 20453842|Jiang 
               
               
                   
                   
                 2.00E−08 
                   
                 L, PMID: 24782177 
               
               
                 STAT4 
                 rs11889341| 
                  1.00E−12| 
                 1.12|1.16 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs7574865 
                  3.00E−07| 
                   
                 E A, PMID: 20453842|Kochi 
               
               
                   
                   
                 2.00E−06 
                   
                 Y, PMID: 20453841 
               
               
                 SYNGR1 
                 rs909685 
                 1.00E−16 
                 1.13 
                 Okada Y, PMID: 24390342 
               
               
                 TAGAP 
                 rs2451258 
                 2.00E−10 
                 1.10 
                 Okada Y, PMID: 24390342 
               
               
                 TEC 
                 rs2664035 
                 1.00E−07 
                 1.07 
                 Okada Y, PMID: 24390342 
               
               
                 TNFAIP3 
                 rs7752903| 
                  2.00E−20| 
                 1.41|1.22| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs6920220| 
                  9.00E−13| 
                 1.38|1.33 
                 E A, PMID: 20453842|Plenge 
               
               
                   
                 rs2230926| 
                  1.00E−07| 
                   
                 R M, PMID: 17982456|Doroth??e 
               
               
                   
                 rs10499194 
                  6.80E−14| 
                   
                 Diogo, PMID: 23261300|Kochi 
               
               
                   
                   
                  2.00E−06| 
                   
                 Y, PMID: 20453841|Plenge 
               
               
                   
                   
                 1.00E−09 
                   
                 R M, PMID: 17982456 
               
               
                 TNFRSF14 
                 chr1: 2523811| 
                  5.00E−09| 
                 1.10|1.12| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs3890745 
                  4.00E−06| 
                 NR|1.12 
                 E A, PMID: 20453842|Orozco 
               
               
                   
                   
                  1.00E−06| 
                   
                 G, PMID: 
               
               
                   
                   
                 1.00E−07 
                   
                 24449572|Raychaudhuri 
               
               
                   
                   
                   
                   
                 S, PMID: 18794853 
               
               
                 TNFRSF9 
                 rs227163 
                 3.00E−09 
                 1.11 
                 Okada Y, PMID: 24390342 
               
               
                 TPD52 
                 rs998731 
                 2.00E−08 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 TRAF1 
                 rs10985070| 
                  4.00E−09| 
                 1.09|1.13| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs3761847| 
                  2.00E−07| 
                 1.10|NR|NR 
                 E A, PMID: 20453842|Doroth??e 
               
               
                   
                 rs2239657| 
                  5.40E−08| 
                   
                 Diogo, PMID:23261300|Gregersen 
               
               
                   
                 rs881375| 
                  4.00E−08| 
                   
                 P K, PMID: 19503088|Jiang 
               
               
                   
                 rs2072438 
                 3.00E−09 
                   
                 L, PMID: 24782177 
               
               
                 TRAF1-C5 
                 rs3761847 
                 4.00E−14 
                 1.32 
                 Plenge R M, PMID: 17804836 
               
               
                 TRAF6 
                 rs331463 
                 1.00E−07 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 TRHDE 
                 rs12831974 
                 6.00E−06 
                 1.27 
                 Freudenberg J, PMID: 21452313 
               
               
                 TXNDC11 
                 rs4780401 
                 4.00E−08 
                 1.07 
                 Okada Y, PMID: 24390342 
               
               
                 TYK2 
                 rs34536443 
                 5.00E−16 
                 1.46 
                 Okada Y, PMID: 24390342 
               
               
                 UBASH3A 
                 rs1893592| 
                  7.00E−12| 
                 1.11|1.11 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs11203203 
                 4.00E−06 
                   
                 E A, PMID: 20453842 
               
               
                 UBE2L3 
                 rs11089637 
                 2.00E−07 
                 1.10 
                 Okada Y, PMID: 24390342 
               
               
                 WDFY4 
                 rs2671692 
                 3.00E−09 
                 1.07 
                 Okada Y, PMID: 24390342 
               
               
                 YDJC 
                 rs11089637 
                 2.00E−07 
                 1.10 
                 Okada Y, PMID: 24390342 
               
               
                 ZNF438 
                 rs793108 
                 1.00E−09 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 ZNF774 
                 rs6496667 
                 1.00E−06 
                 1.09 
                 Okada Y, PMID: 22446963 
               
               
                   
               
            
           
         
       
     
     Example 3 
     Analysis of the Whole-Exome Sequencing (WES) 
     To analyze the entire cohort of samples for genotype calls, variant analysis and joint genotyping were performed according to the pipeline recommended by the Genome Analysis Toolkit software and the GATK Best Practices procedures on RA patients and healthy controls (San Lucas F A et al., Bioinformatics 2012; 28:421-422; and Dong C et al., Human molecular genetics 2015; 24:2125-2137). Briefly, Burrows-Wheeler Aligner (BWA) software was utilized to align the raw sequencing reads in FASTQ formats to the 1000 Genomes (GRCh37+decoy) human genome reference. The BWA alignment files were converted to BAM files with SAMtools v1.1, which was used for sorting the BAM files. Duplicate reads were marked for BAM files with Picard MarkDuplicates (https://sourceforge.net/projects/picard/). The coverage and depth were computed based on the final BAM file. Local realignment, base quality recalibration, variant calling, joint genotyping, and variant quality score recalibration and filtration were applied using with GATK v3.7 (https://software.broadinstitute.org/gatk/). Default settings were used for BWA, SAMtools, Picard and GATK tools. 
     Further filtration for the joint genotyped variants was performed using Variant Tools (San Lucas F A et al., Bioinformatics 2012; 28:421-422). The inventors applied the following filters to generate a list of preliminary variants by removing false-positive variants through Variant Quality Score Recalibration with tranche truth sensitivity threshold &lt;99.00, as well as variants with low read depth (DP)&lt;10 and poor genotyping quality (GQ)&lt;20, keeping exonic or splicing variants based on University of California, Santa Cruz (UCSC) genome browser build 37 human Reference Sequence Gene annotation, and removing synonymous variants. 
     From the preliminary variant list, variants annotated as “pathogenic” in ClinVar and deleterious variants were identified, respectively, including those candidate genes that overlapped with previous studies or passed the case-control gene burden test threshold. Deleterious variants were predicted to be damaging (disease-related, D) or benign/neutral (tolerated, T) based on LR score determined by logistic regression (LR) model (Dong C et al., Human molecular genetics 2015; 24:2125-2137). The novel deleterious variants were divided into the rare and common variant groups, which were distinguished by minor allele frequency (MAF) in Chinese Southern population from the 1000 Genomes Project phase III study. 
     Example 4 
     Analysis of Burden Association Signal 
     Case-control gene burden analysis was assessed on both rare and common deleterious variants to investigate causal genes using RA patients with &gt;80% Chinese ancestry as cases and two types of controls: 105 southern Chinese samples from the 1000 Genomes Project phase III study and 66 healthy controls with &gt;80% Chinese ancestry. Regardless of DP or GQ, all available genotype calls contributed to the number of allele count across the retained deleterious variants in each individual gene. The gene burden ratio was calculated by dividing the allele frequency in cases by the allele frequency in controls. We identified an enrichment of deleterious variants in a gene according to the gene burden ratio &gt;1.5-fold with both types of controls, or the deleterious alleles in the gene with at least 3 RA cases if zero allele frequency in the controls. The inventors further identified genes with rare variants that were homozygous in RA cases but not present in controls, which were considered greater contribution to functional impact. 
     Example 5 
     Pathway Analysis 
     To discover enriched functional-related gene groups, pathway analysis was performed using DAVID Bioinformatics Resource 6.8 program (DAVID 6.8) (https://david.ncifcrf.gov/summary.jsp) with a Modified Fisher Exact P value less than 0.05 as the significance threshold and strong enrichment in the annotation categories. 
     Homology modeling is one of the best and reliable ways to construct the three dimensional (3D) structure of protein (Yamaguchi H et al., European journal of medicinal chemistry 2011; 46:1325-1330). Firstly, protein sequence was imported into the Molecular Operating Environment (MOE) 2015.09 software (Chemical Computing Group Inc., Montreal, Canada) to search an optimal template. The top ranked structure based on the Z score towards the target sequence was selected as the template. Target protein sequence and its corresponding crystal structure coordinates of template were separately loaded and aligned. A series of protein models were independently constructed by using a Boltzmann-weighted randomized procedure (Levitt M., Journal of molecular biology 1992; 226:507-533). Amber force field was applied in the process of construction and energy minimization (Case D et al., Amber 12 reference manual). Finally, the model with the best packing quality function was selected for further full energy minimization, and the stereochemical qualities of protein model was assessed by means of Ramachandran plots. 
     To analyze the effect on the point mutation in the 3D structure of the protein, the mutant protein were carried out in Residue Scan module of MOE 2015.09 software based on the 3D structure of homology modeling. In addition, we further analyze the hydrogen bonds, solvent interactions, metal ligation and non-bonded interaction between the target mutant residue and its surrounding key amino acid residues. 
     Example 6 
     Results 
     1. Deleterious Variants in Novel RA Candidate Genes 
     WES data were generated from 58 RA patients with a median coverage of 76-fold on targeted exome regions ( FIG. 2A ). An average of 96% of all targeted regions was covered by at least 20-fold. The healthy control group had a median coverage of 68-fold on targeted exome regions, and an average of 94% of those regions was covered by at least 20-fold ( FIG. 2B ). 
     As shown in the flow chart of  FIG. 3 , a total of 3,537,952 variants were identified from 58 RA samples. After applying the quality filters and removing synonymous variants, we found 72,024 exonic and splicing variants, including nonsynonymous substitutions and a small number of stop-gain, stop-loss, frameshift and non-frameshift indels (Table 4). Of these, 135 variants were identified as deleterious based on the “pathogenic” annotation in ClinVar, and an additional 21,755 variants predicted to be deleterious were identified using an ensemble logistic regression score. 
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 Types of exonic, splicing and nonsynonymous 
               
               
                 variants (total = 72,024). 
               
            
           
           
               
               
               
            
               
                   
                 Mutation type 
                 No. of variants 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Nonsynonymous SNV 
                   
                 56,466 
               
               
                   
                 Stop-gain 
                   
                 828 
               
               
                   
                 Stop-loss 
                   
                 49 
               
               
                   
                 Frameshift 
                 Deletion 
                 408 
               
               
                   
                   
                 Insertion 
                 215 
               
               
                   
                 Nonframeshift 
                 Deletion 
                 705 
               
               
                   
                   
                 Insertion 
                 466 
               
               
                   
                 Splicing 
                   
                 11,377 
               
               
                   
                 Unknown 
                   
                 1510 
               
               
                   
                   
               
            
           
         
       
     
     It was surprising that the identified genes were not found in previously reported candidate risk variants GWAS data (group 1 and group 3 in  FIG. 3 ; Table 5 and 6), such as HLA-associated genes. After reviewing the location of the reported RA-associated variants, the inventors found that only 9 of over 200 variants are located in the exome area, including CTLA4 (rs231775), FCGR2A (rs1801274), IL6R (rs2228145), OLIG3 (rs2230926), PTPN22 (rs2476601), RTKN2 (rs3125734), SH2B3 (rs3184504), TNFAIP3 (rs223092) and TYK2 (rs34536443). Since the inventors applied WES technique to focus on exome regions, the results are different from the previously reported studies. It is advantageous that the presently disclosed method of identification of RA associated genes is capable of providing more comprehensive information of RA associated genes. According to the results, a number of new RA associated genes have now been identified and may be useful in developing advanced methods for diagnosis and treatment of RA. 
     Interestingly, two novel risk variant loci were identified associated with TGFβ1 (transforming growth factor β1) and FOXP3 (forkhead box P3) genes (group 4 and group 6 in  FIG. 3 ; Table 5) whereas other known variations of these two genes were previously found to be involved in the risk to RA (Zhou T B et al., J Recept Signal Transduct Res 2014; 34:469-475; and Paradowska-Gorycka A et al., J Rheumatol 2015; 42:170-180). 
     In order to identify novel genes and pathways that could enhance understanding of RA pathogenesis, the inventors performed a gene burden analysis to identify genes for which deleterious variants were enriched in the Han Chinese RA samples compared to healthy control and public control samples. Six such genes were identified (group 2 in  FIG. 3 ; Table 5 and 7). Of these, a missense variant of SAA1 (Serum Amyloid A1) was found in 3 RA patients but not present in healthy controls. SAA1 is highly expressed in response to inflammation and tissue injury, and strongly associated with activity of the disease and risk of cardiovascular and renal involvement in RA patients, suggesting that this novel deleterious variant may potentially contribute to RA disease risk through its interference with pro-inflammatory effectors. Additional pathogenic variant of OXCT1 (3-Oxoacid CoA-Transferase 1) was predicted to be damaging (disease-related, D) in the RA patients, encoding Succinyl-CoA:3-ketoacid coenzyme A transferase 1 (SCOT1), which is a key enzyme for synthesis and degradation of ketone bodies involved in cardiovascular disease. 
     Rare variants are more likely to predict a significant impact on protein function and result in clinically relevant consequences than common ones. Thus, the inventors grouped variants that were indicated to be deleterious into rare (minor allele frequency &lt;1%) and common variants, which did not overlap with previously reported candidates (Table 5). Performing a gene burden analysis for variants within each of these groups, we identified 241 genes (group 4 in  FIG. 3 ; Table 5) with rare, deleterious variants specifically enriched in our Chinese RA samples compared to healthy control and public control samples. Notably, since the functional impact of rare and deleterious variants is likely to be greater when present as homozygote, 5 rare and deleterious homozygous variants (NCR3LG1, RAP1GAP, CHCHD5, HIPK2 and DIAPH2) were identified in the Chinese RA samples and absent in the controls (group 5 in  FIG. 3 ; Table 3). Finally, we also identified 144 genes with common and deleterious variants in RA patients (group 6 in  FIG. 3 ; Table 5). 
     2. Pathway Analysis 
     Using the method as disclosed herein, the inventors identified a total of 381 genes as candidates for increased risk of RA (Table 5). In order to further identify the associated biologic pathways, the inventors performed the functional enrichment analysis using DAVID 6.8 and identified the pathways of the extracellular matrix (ECM)-receptor interaction, protein digestion and absorption, focal adhesion and glycerophospholipid metabolism as significantly overrepresented (Table 8), which were reported to be relevant in pathogenesis of arthritis (Lv W et al., Mol Biosyst 2015; 11:2986-2997; and Choe J Y et al., Rheumatology (Oxford) 2016; 55:928-938). 
     In order to identify variants that might predispose RA patients to disease duration, the inventors repeated the variant filtration and gene burden analysis on Chinese RA samples with the disease duration 3-year compared to the disease duration ≤1-year. A total of 277 genes were identified (Table 9) compared to the 381 genes identified in the case-control comparison (Table 5). Of these, 87 genes were unique to disease duration with exonic variants (Table 10). Pathway analysis performed on the 87 genes identified olfactory transduction pathway as significantly overrepresented (Table 8), including OR14C36, OR4A15, OR52N4, OR6C74, OR6C75, OR7G3 and OR9K2. 
     3. Structural Analysis and Function Change Prediction of Potential Biomarkers 
     In order to gain structure insights of the potential biomarkers with pathogenic variants into the clinical conditions of RA patients, the inventors derived a three-dimensionally structure model of SAA1 Gly90Asp (rs79681911) and SCOT1 Thr58Met (rs75134564) by combining homology modeling with point mutation in MOE 2015.09 package. The crystal structures of human SAA1 protein (PDB code: 41P8.A) and SCOT1 protein (PDB code: 3K6M.C) were selected to be used as templates due to their optimal identity with the target sequences of SAA1 (Protein RefSeq: NP_000322.2) and SCOT1 (Protein RefSeq: NP_000427.1), 83.6% and 83.5%, respectively ( FIG. 4 ). The SAA1 and SCOT1 models with the best packing quality function and full energy minimization were assessed by Ramachandran plots, indicating that the phi and psi backbone dihedral angles in the models were reasonable ( FIG. 5 ). 
     Structural analysis of SAA1 Gly90Asp ( FIGS. 6A and 6B ) revealed that the substitution of glycine with aspartic acid induced the formation of two pairs of hydrogen bonds with two threonine residues (Ala91 and Asp93), exhibiting more stable structure of loop region and promoting the polar interaction. Moreover, this mutation shortened the length of a helix 4, which may affect the stability of SAA1. Structural changes in SAA1 protein caused the surface of Asp90 to be exposed in solvent environment, leading to the increased hydrophilic region. In addition, the construction of 3D models in SCOT1 and its mutant Thr58Met revealed that this substitution resulted in the disappearance of the hydrogen bond between Thr58 and Asp206, the reduction of intramolecular polar interactions and the expansion of hydrophobic region ( FIGS. 6C and 6D ), suggesting its potential function alteration in RA pathogenesis. 
     4. Discussion 
     The inventors performed perspective WES aiming to identify potentially causal biomarkers in a cohort of Chinese RA patients. The inventors used the method as disclosed herein to focus on investigating the occurrence frequency of variants in genes previously associated with RA as well as novel genes. Despite known variants of TGFβ1 and FOXP3 genes associated with increased RA risk, two novel risk variant loci in these two genes were for the first time identified to be implicated in the RA risk (group 4 and group 6 in Table 5). A novel splicing variant (rs199982059) of TGFβ1 was found to be significantly enriched in 4 RA patients, but absent in healthy controls. TGFβ1 is a pivotal protein in the pathogenesis of a number of autoimmune disorders and its dysregulation is also increasingly implicated in the risk of developing RA. RNA splicing is a focal point on connection between genetic variations and complex disorders, and this novel splicing variant of TGFβ1 might provide new insights into the genetic determinants of RA disease. In addition, a novel missense variant (chrX:49114808) of FOXP3 was observed in 8 RA patients. FOXP3 is a unique regulatory T cell (T reg )-specific marker and important in the development of RA-derived T reg  cells as a transcriptional factor. In spite of the other known variants in TGFβ1 and FOXP3 genes associated with RA, these two newly-identified variants in our Chinese RA patients may offer the novel genetic contributions to the RA risk. 
     The inventors have also identified six novel and deleterious genes that are classified as pathogenic in ClinVar database (Table 7). Of these, a missense variant (rs79681911) of SAA1, initially characterized by serum amyloid a variant (OMIM 104750) and required for the amyloidosis disease process, was identified in the RA patients. SAA1 has been reported to play a pathogenic role in the pro-inflammatory cascades in RA, therefore, this novel deleterious variant may be implicated in RA risk as a sensitive indicator of inflammatory activity. Additional pathogenic variant (rs75134564) of OXCT1 was predicted to be disease-related in 4 RA patients based on LR score, which previously implicated in succinyl-CoA acetoacetate transferase deficiency (OMIM 601424) in clinic. OXCT1 encoding enzyme SCOT1 is essential for ketone body metabolism and involved in cardiovascular disease, which are shown to be strongly associated with the course of RA, suggesting this enzyme may potentially contribute to RA prognosis. Importantly, the 3D structural analysis of these two potential biomarkers revealed that the substitution of mutation points may be involved in the functional alteration of the proteins and further impact on RA disease progression ( FIG. 6 ). 
     The inventors sought to identify novel genes or biological candidate pathways fundamental to the risk of RA disease, including both rare and common variants. To elucidate additive effects of polygenic variants that affect the same gene or pathway, the inventors performed gene burden test and pathway analysis. Notably, the biological impact of rare and deleterious variants is likely to be greater when present as two copies. In the study, 5 homozygous variants (group 5 in  FIG. 3 ; Table 5) were detected in the RA patients but not in healthy controls. Intriguingly, a non-frameshift indel variant (rs61406813) of NCR3LG1 (natural cytotoxicity triggering receptor 3 ligand 1) was identified in the RA patients as homozygote. NCR3LG1 could be detected on monocytes and neutrophils after application of inflammatory stimuli, and it was initially described as a tumor cell-expressed ligand of NKp30, which is found to be implicated in RA-associated inflammation. Additionally, a missense variant (rs61014678) of RAP1GAP (RAP1 GTPase Activating Protein) was identified as damaging (disease-related, D) by determinant of LR model in the RA patients. RAP1GAP regulates the activity of the ras-related RAP1 protein, which involves in induction of apoptotic pathway in synovial fibroblasts and plays a critical role in oxidative stress and T cell behavior in RA synovial tissues. Thus, these two homozygous variants may perform stronger functions in RA pathogenic mechanisms. 
     The WES analysis totally identified 381 genes that may partially contribute to RA pathogenesis and disease progression, including 3 genes (TGFβ1, FOXP3 and SAA1) previously implicated in RA and 378 novel candidate genes. Biologic pathway analysis might help us to deeply understand RA pathogenesis, and previously biological pathways have been identified from genes in large-scale association analysis of GWAS data (Table 6), such as autoimmune thyroid disease, natural killer cell mediated cytotoxicity and T cell receptor signaling pathways. The inventors deciphered enrichment of the identified deleterious genes within additional pathways of ECM-receptor interaction, protein digestion and absorption, focal adhesion and glycerophospholipid metabolism based on our WES data (Table 8), which have been implicated in the autoimmune conditions or pathogenesis of RA. The inventors also sought to identify potential deleterious variants associated with disease duration among RA patients. The pathway analysis focusing on variants enriched among RA patients with disease duration ≥3-year highlighted seven novel genes in olfactory transduction pathway (Table 8), which has been previously reported to be implicated in regulating inflammatory responses. 
     Pathogenesis of RA is complicated and includes both environmental and genetic factors. Recently, gut microbiota has been evident of being implicated in RA pathogenesis and treatment responses as a critical environmental factor that influences metabolic and immune homeostasis, involvement of protein digestion and absorption, glycerophospholipid metabolism and olfactory transduction pathway, which were also enriched by novel candidate genes identified in the Chinese RA patients (Table 5). In addition, the homozygous variant NCR3LG1 (group 5 in Table 5) may mediate autoimmune and microbial infection-induced inflammation by associating with the ligand of NKp30. Therefore, these involved novel deleterious genes might be convincingly considered genetic contributions to microbial alteration in relation to the pathogenesis and development of RA. 
     Genetic factors on the X chromosome always contribute to the increased risk of developing autoimmune disorders in females compared with males, such as RA. According to the method as described herein, four novel and deleterious variants were investigated to be associated with sex bias in the Chinese RA patients, including OTC (Ornithine Transcarbamylase) (rs72554348), DIAPH2 (Diaphanous Related Formin 2) (rs363755), ARSE (Arylsulfatase E) (rs56393981) and FOXP3 (chrX:49114808) ( FIG. 7 ). Notably, OTC, ARSE and FOXP3 were previously reported to be implicated in x-linked diseases (Bennett C L et al., Nature genetics 2001; 27:20; Luksan 0 et al., Hum Mutat 2010; 31:E1294-1303; and Jeon G W et al., Ann Clin Lab 2013; 43:70-75), in which these three novel variants identified in the present study are also associated with female, supporting that the association of variants on X chromosome and RA may further provide molecular evidence as a risk factor contributing to increased susceptibility in Chinese female RA patients. 
     In summary, the inventors have performed WES to present support and improve our understanding of associations with genetic biomarkers that may be involved in the development of RA in the Chinese population. The biomarkers highlighted include previously implicated genes as well as novel genes and pathways, involved in regulation of adaptive immune response, transmission of nerve impulse and chromosome organization. This study significantly extends the work of GWAS and provides new insight into fundamental etiologic mechanisms in this common autoimmune disease. Taken together, these novel biomarkers can be served as novel biomarkers for valid diagnosis tools for identification of RA patients from normal people specifically for Chinese Han population. 
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 Candidate variant list from RA versus control comparison. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                 Total No. of 
                 No. alt 
                   
                   
               
               
                   
                 Gene burden 
                 alleles 
                 alleles 
                   
                 Variant allele 
               
               
                   
                 ratio 
                 in gene 
                 in genes 
                 No. of cases 
                 frequency 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                   
                   
                   
                 KG East 
                 healthy 
                 healthy 
                   
                 healthy 
                   
                 with alt 
                 KG 
               
               
                 group 
                 chr 
                 pos 
                 id 
                 ref 
                 alt 
                 gene 
                 LR 
                 Asia 
                 Ctrl 
                 Ctrl 
                 RA 
                 Ctrl 
                 RA 
                 alleles 
                 East Asia 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 2 
                 10 
                 101829514 
                 rs61751507 
                 C 
                 T 
                 CPN1 
                 T 
                 1.81 
                 1.52 
                 132 
                 116 
                 3 
                 4 
                 4 
                 0.0248 
               
               
                   
               
               
                 2 
                 11 
                 18291302 
                 rs79681911 
                 G 
                 A 
                 SAA1 
                 T 
                 1.81 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
                 0.0198 
               
               
                   
               
               
                 2 
                 3 
                 133476698 
                 rs41295774 
                 A 
                 G 
                 TF 
                 T 
                 1.81 
                 3.41 
                 132 
                 116 
                 2 
                 6 
                 6 
                 0.0238 
               
               
                   
               
               
                 2 
                 5 
                 41862758 
                 rs75134564 
                 G 
                 A 
                 OXCT1 
                 D 
                 3.62 
                 4.55 
                 132 
                 116 
                 1 
                 4 
                 4 
                 0.0069 
               
               
                   
               
               
                 2 
                 7 
                 44104839 
                 rs77938727 
                 C 
                 T 
                 PGAM2 
                 D 
                 1.81 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0129 
               
               
                   
               
               
                 2 
                 X 
                 38229135 
                 rs72554348 
                 G 
                 C 
                 OTC 
                 . 
                 2.79 
                 2.32 
                 132 
                 114 
                 3 
                 6 
                 5 
                 0.0144 
               
               
                   
               
               
                 4 
                 10 
                 102027318 
                 rs200164003 
                 G 
                 C 
                 CWF19L1 
                 . 
                 7.24 
                 . 
                 132 
                 116 
                 0 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 10 
                 114917776 
                 rs191206106 
                 C 
                 G 
                 TCF7L2 
                 . 
                 12.67 
                 7.97 
                 264 
                 232 
                 1 
                 7 
                 7 
                 0.001 
               
               
                   
               
               
                 4 
                 10 
                 114925441 
                 rs138649767 
                 G 
                 A 
                 TCF7L2 
                 D 
                 12.67 
                 7.97 
                 264 
                 232 
                 1 
                 7 
                 7 
                 0.0089 
               
               
                   
               
               
                 4 
                 10 
                 135086331 
                 rs536126291 
                 C 
                 T 
                 ADAM8 
                 . 
                 5.43 
                 3.41 
                 264 
                 232 
                 1 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 10 
                 135087305 
                 rs3810960 
                 G 
                 A 
                 ADAM8 
                 . 
                 5.43 
                 3.41 
                 264 
                 232 
                 1 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 10 
                 25144247 
                 rs199794379 
                 A 
                 G 
                 PRTFDC1 
                 D 
                 5.43 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 10 
                 25147326 
                 rs199983667 
                 C 
                 A 
                 PRTFDC1 
                 D 
                 5.43 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 10 
                 35894560 
                 rs142589386 
                 G 
                 A 
                 GJD4 
                 . 
                 5.43 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 10 
                 35897091 
                 rs547212582 
                 T 
                 C 
                 GJD4 
                 D 
                 5.43 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 10 
                 35897205 
                 rs192362407 
                 G 
                 A 
                 GJD4 
                 D 
                 5.43 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 10 
                 50854641 
                 rs539884711 
                 C 
                 A 
                 CHAT 
                 D 
                 1.81 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 10 
                 50857631 
                 rs201293521 
                 G 
                 T 
                 CHAT 
                 D 
                 1.81 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 10 
                 50870806 
                 rs116628504 
                 G 
                 A 
                 CHAT 
                 D 
                 1.81 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 1 
                 100174455 
                 rs192583899 
                 T 
                 C 
                 FRRS1 
                 . 
                 1.81 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 1 
                 100177969 
                 rs187278122 
                 A 
                 G 
                 FRRS1 
                 . 
                 1.81 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.006 
               
               
                   
               
               
                 4 
                 1 
                 103444283 
                 rs192842970 
                 G 
                 A 
                 COL11A1 
                 D 
                 10.86 
                 3.4 
                 394 
                 348 
                 2 
                 6 
                 6 
                 0.004 
               
               
                   
               
               
                 4 
                 1 
                 103468295 
                 rs2622875 
                 C 
                 T 
                 COL11A1 
                 . 
                 10.86 
                 3.4 
                 394 
                 348 
                 2 
                 6 
                 6 
                 0.001 
               
               
                   
               
               
                 4 
                 1 
                 103544434 
                 rs12136865 
                 A 
                 G 
                 COL11A1 
                 . 
                 10.86 
                 3.4 
                 394 
                 348 
                 2 
                 6 
                 6 
                 0.001 
               
               
                   
               
               
                 4 
                 11 
                 111857624 
                 . 
                 T 
                 C 
                 DIXDC1 
                 . 
                 5.43 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 11 
                 111889694 
                 . 
                 T 
                 C 
                 DIXDC1 
                 . 
                 5.43 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 11 
                 121426036 
                 rs140499624 
                 A 
                 G 
                 SORL1 
                 . 
                 7.24 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 11 
                 124006828 
                 rs2276055 
                 C 
                 T 
                 VWA5A 
                 . 
                 7.24 
                 . 
                 132 
                 116 
                 0 
                 4 
                 4 
                 0.0079 
               
               
                   
               
               
                 4 
                 11 
                 124742777 
                 rs117828759 
                 C 
                 T 
                 ROBO3 
                 . 
                 4.95 
                 2.01 
                 128 
                 106 
                 3 
                 5 
                 5 
                 0.0079 
               
               
                   
               
               
                 4 
                 11 
                 2432720 
                 rs548094761 
                 C 
                 T 
                 TRPM5 
                 D 
                 3.62 
                 6.83 
                 396 
                 348 
                 1 
                 6 
                 6 
                 0.003 
               
               
                   
               
               
                 4 
                 11 
                 2434772 
                 rs74570003 
                 G 
                 T 
                 TRPM5 
                 D 
                 3.62 
                 6.83 
                 396 
                 348 
                 1 
                 6 
                 6 
                 0.003 
               
               
                   
               
               
                 4 
                 11 
                 2441443 
                 rs201184691 
                 G 
                 A 
                 TRPM5 
                 . 
                 3.62 
                 6.83 
                 396 
                 348 
                 1 
                 6 
                 6 
                 0.004 
               
               
                   
               
               
                 4 
                 1 
                 1267086 
                 rs201655269 
                 C 
                 T 
                 TAS1R3 
                 D 
                 7.24 
                 4.55 
                 396 
                 348 
                 1 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 1 
                 1268119 
                 rs548456115 
                 C 
                 T 
                 TAS1R3 
                 D 
                 7.24 
                 4.55 
                 396 
                 348 
                 1 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 1 
                 1269146 
                 rs576045705 
                 G 
                 A 
                 TAS1R3 
                 D 
                 7.24 
                 4.55 
                 396 
                 348 
                 1 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 11 
                 2909699 
                 rs80153297 
                 C 
                 T 
                 SLC22A18AS 
                 . 
                 2.41 
                 . 
                 264 
                 232 
                 0 
                 4 
                 4 
                 0.005 
               
               
                   
               
               
                 4 
                 11 
                 2920835 
                 rs189560463 
                 G 
                 C 
                 SLC22A18AS 
                 . 
                 2.41 
                 . 
                 264 
                 232 
                 0 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 1 
                 146759364 
                 . 
                 C 
                 T 
                 CHD1L 
                 . 
                 5.62 
                 3.54 
                 132 
                 112 
                 1 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 11 
                 479160 
                 rs2301168 
                 G 
                 T 
                 PTDSS2 
                 . 
                 3.62 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 11 
                 490416 
                 rs200466000 
                 C 
                 T 
                 PTDSS2 
                 . 
                 3.62 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.004 
               
               
                   
               
               
                 4 
                 1 
                 151958735 
                 rs190916122 
                 A 
                 G 
                 S100A10 
                 . 
                 5.43 
                 1.68 
                 130 
                 116 
                 2 
                 3 
                 3 
                 0.005 
               
               
                   
               
               
                 4 
                 11 
                 56756398 
                 rs13343184 
                 G 
                 T 
                 OR5AK2 
                 . 
                 2.72 
                 3.41 
                 264 
                 232 
                 1 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 11 
                 56756578 
                 rs189588796 
                 C 
                 T 
                 OR5AK2 
                 . 
                 2.72 
                 3.41 
                 264 
                 232 
                 1 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 1 
                 160121885 
                 rs146860131 
                 C 
                 T 
                 ATP1A4 
                 . 
                 10.86 
                 3.41 
                 528 
                 464 
                 2 
                 6 
                 6 
                 0.003 
               
               
                   
               
               
                 4 
                 1 
                 160143514 
                 rs45441496 
                 T 
                 G 
                 ATP1A4 
                 . 
                 10.86 
                 3.41 
                 528 
                 464 
                 2 
                 6 
                 6 
                 0.0089 
               
               
                   
               
               
                 4 
                 1 
                 160143945 
                 rs199962758 
                 T 
                 C 
                 ATP1A4 
                 D 
                 10.86 
                 3.41 
                 528 
                 464 
                 2 
                 6 
                 6 
                 0.003 
               
               
                   
               
               
                 4 
                 1 
                 160144538 
                 rs185461260 
                 G 
                 T 
                 ATP1A4 
                 . 
                 10.86 
                 3.41 
                 528 
                 464 
                 2 
                 6 
                 6 
                 0.004 
               
               
                   
               
               
                 4 
                 1 
                 161090011 
                 rs201971149 
                 G 
                 C 
                 NIT1 
                 D 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 11 
                 63400493 
                 rs17656941 
                 C 
                 T 
                 ATL3 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 11 
                 63403670 
                 rs3781606 
                 C 
                 T 
                 ATL3 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.0079 
               
               
                   
               
               
                 4 
                 11 
                 6585361 
                 rs113574909 
                 A 
                 G 
                 DNHD1 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0099 
               
               
                   
               
               
                 4 
                 11 
                 67786664 
                 rs535638253 
                 G 
                 A 
                 ALDH3B1 
                 . 
                 1.81 
                 2.84 
                 528 
                 464 
                 2 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 11 
                 67789111 
                 rs371833737 
                 C 
                 T 
                 ALDH3B1 
                 . 
                 1.81 
                 2.84 
                 528 
                 464 
                 2 
                 5 
                 5 
                 0.003 
               
               
                   
               
               
                 4 
                 11 
                 67789277 
                 rs370461081 
                 G 
                 A 
                 ALDH3B1 
                 . 
                 1.81 
                 2.84 
                 528 
                 464 
                 2 
                 5 
                 5 
                 0.002 
               
               
                   
               
               
                 4 
                 11 
                 67795344 
                 rs374814356 
                 G 
                 A 
                 ALDH3B1 
                 . 
                 1.81 
                 2.84 
                 528 
                 464 
                 2 
                 5 
                 5 
                 0.005 
               
               
                   
               
               
                 4 
                 11 
                 74716666 
                 rs202090872 
                 G 
                 C 
                 NEU3 
                 D 
                 5.43 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 11 
                 74716935 
                 rs200629627 
                 G 
                 A 
                 NEU3 
                 D 
                 5.43 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 11 
                 74717001 
                 rs539514716 
                 C 
                 T 
                 NEU3 
                 D 
                 5.43 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 1 
                 176853472 
                 rs79630456 
                 C 
                 T 
                 ASTN1 
                 . 
                 2.72 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.0089 
               
               
                   
               
               
                 4 
                 11 
                 76873966 
                 . 
                 C 
                 T 
                 MYO7A 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 11 
                 76900487 
                 . 
                 G 
                 C 
                 MYO7A 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 1 
                 17949680 
                 rs75914589 
                 C 
                 T 
                 ARHGEF10L 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0089 
               
               
                   
               
               
                 4 
                 11 
                 82536079 
                 rs202237309 
                 C 
                 T 
                 PRCP 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 11 
                 82549453 
                 rs536616254 
                 C 
                 T 
                 PRCP 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 11 
                 82644887 
                 rs553247583 
                 G 
                 GC 
                 DDIAS 
                 . 
                 1.81 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 1 
                 183084778 
                 rs200671087 
                 A 
                 G 
                 LAMC1 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 1 
                 183086586 
                 rs544527088 
                 G 
                 A 
                 LAMC1 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 11 
                 8959479 
                 rs147479456 
                 G 
                 A 
                 ASCL3 
                 D 
                 3.62 
                 . 
                 264 
                 232 
                 0 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 11 
                 8959607 
                 rs201803232 
                 C 
                 T 
                 ASCL3 
                 D 
                 3.62 
                 . 
                 264 
                 232 
                 0 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 11 
                 93754643 
                 rs192979315 
                 T 
                 A 
                 HEPHL1 
                 D 
                 5.43 
                 6.83 
                 528 
                 464 
                 1 
                 6 
                 6 
                 0.002 
               
               
                   
               
               
                 4 
                 11 
                 93754667 
                 rs564600266 
                 A 
                 G 
                 HEPHL1 
                 D 
                 5.43 
                 6.83 
                 528 
                 464 
                 1 
                 6 
                 6 
                 0.005 
               
               
                   
               
               
                 4 
                 11 
                 93779075 
                 rs151306000 
                 A 
                 T 
                 HEPHL1 
                 D 
                 5.43 
                 6.83 
                 528 
                 464 
                 1 
                 6 
                 6 
                 0.0069 
               
               
                   
               
               
                 4 
                 11 
                 93797581 
                 rs146491431 
                 G 
                 C 
                 HEPHL1 
                 D 
                 5.43 
                 6.83 
                 528 
                 464 
                 1 
                 6 
                 6 
                 0.002 
               
               
                   
               
               
                 4 
                 1 
                 19566783 
                 rs201918168 
                 C 
                 T 
                 EMC1 
                 . 
                 1.81 
                 3.41 
                 132 
                 116 
                 1 
                 3 
                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 1 
                 197070906 
                 rs118010078 
                 C 
                 T 
                 ASPM 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 4 
                 0.0069 
               
               
                   
               
               
                 4 
                 1 
                 197072871 
                 rs144969324 
                 C 
                 T 
                 ASPM 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 4 
                 0.005 
               
               
                   
               
               
                 4 
                 1 
                 203195004 
                 rs190551025 
                 C 
                 T 
                 CHIT1 
                 . 
                 3.62 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.006 
               
               
                   
               
               
                 4 
                 1 
                 203198732 
                 rs16851144 
                 C 
                 T 
                 CHIT1 
                 . 
                 3.62 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 12 
                 122247945 
                 rs375525174 
                 G 
                 T 
                 SETD1B 
                 D 
                 7.24 
                 1.52 
                 264 
                 232 
                 3 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 12 
                 122261544 
                 rs553963413 
                 G 
                 A 
                 SETD1B 
                 D 
                 7.24 
                 1.52 
                 264 
                 232 
                 3 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 12 
                 12672941 
                 rs187382315 
                 T 
                 G 
                 DUSP16 
                 . 
                 7.24 
                 2.24 
                 130 
                 116 
                 2 
                 4 
                 4 
                 0.005 
               
               
                   
               
               
                 4 
                 1 
                 21926031 
                 rs138045307 
                 C 
                 T 
                 RAP1GAP 
                 D 
                 7.24 
                 4.55 
                 264 
                 232 
                 2 
                 8 
                 7 
                 0.001 
               
               
                   
               
               
                 4 
                 1 
                 22149838 
                 rs554059442 
                 C 
                 T 
                 HSPG2 
                 D 
                 2.72 
                 . 
                 396 
                 348 
                 0 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 1 
                 22157470 
                 rs77527456 
                 C 
                 T 
                 HSPG2 
                 . 
                 2.72 
                 . 
                 396 
                 348 
                 0 
                 3 
                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 1 
                 22157544 
                 rs368497178 
                 C 
                 T 
                 HSPG2 
                 D 
                 2.72 
                 . 
                 396 
                 348 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 1 
                 225599137 
                 rs192884088 
                 C 
                 T 
                 LBR 
                 D 
                 3.64 
                 4.55 
                 526 
                 462 
                 1 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 1 
                 225600276 
                 rs145104817 
                 C 
                 T 
                 LBR 
                 D 
                 3.64 
                 4.55 
                 526 
                 462 
                 1 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 1 
                 225607507 
                 rs144956313 
                 T 
                 A 
                 LBR 
                 . 
                 3.64 
                 4.55 
                 526 
                 462 
                 1 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 1 
                 225611800 
                 rs375540112 
                 T 
                 C 
                 LBR 
                 . 
                 3.64 
                 4.55 
                 526 
                 462 
                 1 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 1 
                 228109706 
                 rs146233417 
                 C 
                 A 
                 WNT9A 
                 . 
                 5.43 
                 3.41 
                 132 
                 116 
                 1 
                 3 
                 3 
                 0.005 
               
               
                   
               
               
                 4 
                 1 
                 23281822 
                 rs543523784 
                 C 
                 T 
                 LACTBL1 
                 . 
                 3.62 
                 2.28 
                 528 
                 464 
                 2 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 1 
                 23285238 
                 rs374793392 
                 C 
                 T 
                 LACTBL1 
                 . 
                 3.62 
                 2.28 
                 528 
                 464 
                 2 
                 4 
                 4 
                 0.004 
               
               
                   
               
               
                 4 
                 1 
                 23285418 
                 rs186492394 
                 A 
                 G 
                 LACTBL1 
                 . 
                 3.62 
                 2.28 
                 528 
                 464 
                 2 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 1 
                 23289623 
                 rs557724162 
                 C 
                 T 
                 LACTBL1 
                 . 
                 3.62 
                 2.28 
                 528 
                 464 
                 2 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 1 
                 241850753 
                 rs146579868 
                 T 
                 C 
                 WDR64 
                 . 
                 7.24 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 1 
                 241929510 
                 rs576824811 
                 C 
                 T 
                 WDR64 
                 . 
                 7.24 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 12 
                 52822463 
                 rs192170292 
                 A 
                 T 
                 KRT75 
                 D 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 12 
                 52825806 
                 rs548132126 
                 A 
                 G 
                 KRT75 
                 D 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 12 
                 52908938 
                 rs375140289 
                 C 
                 T 
                 KRT5 
                 D 
                 5.43 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 12 
                 52913517 
                 rs638907 
                 G 
                 A 
                 KRT5 
                 . 
                 5.43 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 1 
                 27875517 
                 rs111827498 
                 AAGG 
                 A 
                 AHDC1 
                 . 
                 7.24 
                 . 
                 132 
                 116 
                 0 
                 4 
                 4 
                 0.004 
               
               
                   
               
               
                 4 
                 12 
                 94613786 
                 rs117324576 
                 G 
                 A 
                 PLXNC1 
                 . 
                 9.05 
                 1.9 
                 132 
                 116 
                 3 
                 5 
                 5 
                 0.0099 
               
               
                   
               
               
                 4 
                 12 
                 99478699 
                 rs370166322 
                 T 
                 C 
                 ANKS1B 
                 . 
                 3.85 
                 2.22 
                 242 
                 218 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 12 
                 99640652 
                 rs74712860 
                 G 
                 A 
                 ANKS1B 
                 . 
                 3.85 
                 2.22 
                 242 
                 218 
                 1 
                 2 
                 2 
                 0.0079 
               
               
                   
               
               
                 4 
                 13 
                 103392313 
                 rs372526941 
                 C 
                 G 
                 CCDC168 
                 . 
                 2.72 
                 1.71 
                 396 
                 348 
                 2 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 13 
                 103396838 
                 rs183822515 
                 A 
                 G 
                 CCDC168 
                 . 
                 2.72 
                 1.71 
                 396 
                 348 
                 2 
                 3 
                 3 
                 0.006 
               
               
                   
               
               
                 4 
                 13 
                 103397088 
                 rs192109030 
                 C 
                 T 
                 CCDC168 
                 . 
                 2.72 
                 1.71 
                 396 
                 348 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 13 
                 106142185 
                 rs113341591 
                 C 
                 T 
                 DAOA 
                 . 
                 6.34 
                 2.66 
                 264 
                 232 
                 3 
                 7 
                 7 
                 0.0069 
               
               
                   
               
               
                 4 
                 13 
                 106142236 
                 rs111916808 
                 G 
                 A 
                 DAOA 
                 . 
                 6.34 
                 2.66 
                 264 
                 232 
                 3 
                 7 
                 7 
                 0.0099 
               
               
                   
               
               
                 4 
                 1 
                 35226964 
                 rs146378222 
                 G 
                 A 
                 GJB4 
                 D 
                 3.02 
                 1.9 
                 528 
                 464 
                 3 
                 5 
                 5 
                 0.006 
               
               
                   
               
               
                 4 
                 1 
                 35227225 
                 rs373126632 
                 C 
                 T 
                 GJB4 
                 D 
                 3.02 
                 1.9 
                 528 
                 464 
                 3 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 1 
                 35227231 
                 rs146979528 
                 G 
                 A 
                 GJB4 
                 D 
                 3.02 
                 1.9 
                 528 
                 464 
                 3 
                 5 
                 5 
                 0.002 
               
               
                   
               
               
                 4 
                 1 
                 35227585 
                 rs201000959 
                 C 
                 T 
                 GJB4 
                 D 
                 3.02 
                 1.9 
                 528 
                 464 
                 3 
                 5 
                 5 
                 0.003 
               
               
                   
               
               
                 4 
                 1 
                 35350573 
                 rs34565935 
                 CT 
                 C 
                 DLGAP3 
                 . 
                 1.81 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 1 
                 36056256 
                 rs114404250 
                 G 
                 A 
                 TFAP2E 
                 D 
                 2.72 
                 3.41 
                 132 
                 116 
                 1 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 13 
                 76378421 
                 rs190172966 
                 A 
                 T 
                 LMO7 
                 . 
                 3.62 
                 . 
                 396 
                 348 
                 0 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 13 
                 76395306 
                 rs181473989 
                 C 
                 T 
                 LMO7 
                 . 
                 3.62 
                 . 
                 396 
                 348 
                 0 
                 4 
                 4 
                 0.005 
               
               
                   
               
               
                 4 
                 13 
                 76419523 
                 rs566129586 
                 C 
                 T 
                 LMO7 
                 . 
                 3.62 
                 . 
                 396 
                 348 
                 0 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 1 
                 38025103 
                 rs41267309 
                 T 
                 C 
                 DNALI1 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0089 
               
               
                   
               
               
                 4 
                 13 
                 95117993 
                 rs144365832 
                 C 
                 T 
                 DCT 
                 D 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 13 
                 95121301 
                 rs202004134 
                 T 
                 C 
                 DCT 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 14 
                 21793077 
                 rs543867152 
                 C 
                 T 
                 RPGRIP1 
                 D 
                 7.24 
                 . 
                 264 
                 232 
                 0 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 14 
                 21793236 
                 rs7157052 
                 G 
                 A 
                 RPGRIP1 
                 . 
                 7.24 
                 . 
                 264 
                 232 
                 0 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 1 
                 43664319 
                 rs10711519 
                 TA 
                 T 
                 CFAP57 
                 . 
                 7.54 
                 2.3 
                 384 
                 334 
                 2 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 1 
                 43688508 
                 rs549638533 
                 T 
                 TCAC 
                 CFAP57 
                 . 
                 7.54 
                 2.3 
                 384 
                 334 
                 2 
                 4 
                 4 
                 0.005 
               
               
                   
               
               
                 4 
                 1 
                 43689879 
                 rs138114943 
                 C 
                 A 
                 CFAP57 
                 . 
                 7.54 
                 2.3 
                 384 
                 334 
                 2 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 14 
                 59954385 
                 rs76472382 
                 A 
                 G 
                 JKAMP 
                 . 
                 2.72 
                 . 
                 130 
                 116 
                 0 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 14 
                 77735581 
                 rs117207261 
                 C 
                 G 
                 NGB 
                 D 
                 2.72 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 14 
                 77735593 
                 rs77722833 
                 G 
                 C 
                 NGB 
                 D 
                 2.72 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 14 
                 88406259 
                 rs138577661 
                 A 
                 G 
                 GALC 
                 D 
                 7.24 
                 2.28 
                 396 
                 348 
                 2 
                 4 
                 4 
                 0.0079 
               
               
                   
               
               
                 4 
                 14 
                 88411994 
                 rs146286491 
                 C 
                 T 
                 GALC 
                 D 
                 7.24 
                 2.28 
                 396 
                 348 
                 2 
                 4 
                 4 
                 0.006 
               
               
                   
               
               
                 4 
                 14 
                 88450836 
                 rs534598133 
                 C 
                 T 
                 GALC 
                 D 
                 7.24 
                 2.28 
                 396 
                 348 
                 2 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 15 
                 39876498 
                 rs200938835 
                 T 
                 C 
                 THBS1 
                 . 
                 3.62 
                 4.55 
                 396 
                 348 
                 1 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 15 
                 39881204 
                 rs200366954 
                 A 
                 G 
                 THBS1 
                 D 
                 3.62 
                 4.55 
                 396 
                 348 
                 1 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 15 
                 39886402 
                 rs185847032 
                 G 
                 A 
                 THBS1 
                 . 
                 3.62 
                 4.55 
                 396 
                 348 
                 1 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 15 
                 45388079 
                 rs147945181 
                 G 
                 A 
                 DUOX2 
                 D 
                 4.07 
                 1.71 
                 660 
                 580 
                 6 
                 9 
                 9 
                 0.005 
               
               
                   
               
               
                 4 
                 15 
                 45388106 
                 rs200541410 
                 G 
                 A 
                 DUOX2 
                 D 
                 4.07 
                 1.71 
                 660 
                 580 
                 6 
                 9 
                 9 
                 0.004 
               
               
                   
               
               
                 4 
                 15 
                 45391946 
                 rs368488511 
                 C 
                 T 
                 DUOX2 
                 D 
                 4.07 
                 1.71 
                 660 
                 580 
                 6 
                 9 
                 9 
                 0.002 
               
               
                   
               
               
                 4 
                 15 
                 45399533 
                 rs76411432 
                 C 
                 T 
                 DUOX2 
                 . 
                 4.07 
                 1.71 
                 660 
                 580 
                 6 
                 9 
                 9 
                 0.005 
               
               
                   
               
               
                 4 
                 15 
                 45399648 
                 rs180671269 
                 T 
                 A 
                 DUOX2 
                 . 
                 4.07 
                 1.71 
                 660 
                 580 
                 6 
                 9 
                 9 
                 0.003 
               
               
                   
               
               
                 4 
                 1 
                 54694412 
                 rs75191666 
                 G 
                 A 
                 SSBP3 
                 . 
                 2.84 
                 3.35 
                 248 
                 222 
                 1 
                 3 
                 3 
                 0.0099 
               
               
                   
               
               
                 4 
                 1 
                 54707891 
                 rs199692606 
                 A 
                 G 
                 SSBP3 
                 . 
                 2.84 
                 3.35 
                 248 
                 222 
                 1 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 15 
                 48512855 
                 rs116848967 
                 G 
                 A 
                 SLC12A1 
                 D 
                 10.86 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 15 
                 48566800 
                 rs201516084 
                 T 
                 C 
                 SLC12A1 
                 D 
                 10.86 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.005 
               
               
                   
               
               
                 4 
                 15 
                 65766537 
                 rs192889990 
                 A 
                 G 
                 DPP8 
                 . 
                 5.43 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 15 
                 65790192 
                 rs564795298 
                 T 
                 C 
                 DPP8 
                 . 
                 5.43 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 15 
                 79298783 
                 rs182075492 
                 G 
                 C 
                 RASGRF1 
                 . 
                 1.81 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
                 0.005 
               
               
                   
               
               
                 4 
                 15 
                 89869833 
                 rs55962804 
                 C 
                 T 
                 POLG 
                 . 
                 2.72 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.0089 
               
               
                   
               
               
                 4 
                 15 
                 99670848 
                 . 
                 G 
                 A 
                 SYNM 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 15 
                 99673059 
                 . 
                 C 
                 T 
                 SYNM 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 1 
                 6184131 
                 rs200938629 
                 T 
                 A 
                 CHD5 
                 D 
                 1.81 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 1 
                 6188678 
                 rs193121978 
                 C 
                 G 
                 CHD5 
                 . 
                 1.81 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 1 
                 6228290 
                 rs571052710 
                 C 
                 G 
                 CHD5 
                 D 
                 1.81 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 16 
                 19883621 
                 rs200345676 
                 G 
                 T 
                 GPRC5B 
                 D 
                 1.81 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0079 
               
               
                   
               
               
                 4 
                 16 
                 27492392 
                 rs200888316 
                 C 
                 T 
                 GTF3C1 
                 . 
                 5.43 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 16 
                 27494449 
                 rs536534746 
                 G 
                 A 
                 GTF3C1 
                 . 
                 5.43 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 16 
                 424403 
                 rs11641325 
                 C 
                 T 
                 TMEM8A 
                 . 
                 5.48 
                 3.42 
                 262 
                 230 
                 1 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 16 
                 426536 
                 rs143874266 
                 C 
                 T 
                 TMEM8A 
                 . 
                 5.48 
                 3.42 
                 262 
                 230 
                 1 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 16 
                 4624799 
                 rs574569398 
                 C 
                 G 
                 C16orf96 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 16 
                 4644389 
                 rs139232890 
                 CAGG 
                 C 
                 C16orf96 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 16 
                 57935248 
                 rs374813501 
                 C 
                 G 
                 CNGB1 
                 . 
                 3.62 
                 4.55 
                 528 
                 464 
                 1 
                 4 
                 4 
                 0.0069 
               
               
                   
               
               
                 4 
                 16 
                 57984441 
                 rs146170855 
                 C 
                 T 
                 CNGB1 
                 D 
                 3.62 
                 4.55 
                 528 
                 464 
                 1 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 16 
                 57993840 
                 rs201703193 
                 C 
                 T 
                 CNGB1 
                 D 
                 3.62 
                 4.55 
                 528 
                 464 
                 1 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 16 
                 57996967 
                 rs570828500 
                 G 
                 A 
                 CNGB1 
                 D 
                 3.62 
                 4.55 
                 528 
                 464 
                 1 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 1 
                 6638781 
                 rs201116489 
                 C 
                 T 
                 TAS1R1 
                 D 
                 2.72 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 1 
                 6638995 
                 rs150612979 
                 C 
                 T 
                 TAS1R1 
                 D 
                 2.72 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.006 
               
               
                   
               
               
                 4 
                 16 
                 75642789 
                 rs191524413 
                 G 
                 C 
                 ADAT1 
                 D 
                 2.72 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 16 
                 75646659 
                 rs536106427 
                 A 
                 T 
                 ADAT1 
                 D 
                 2.72 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 16 
                 84476135 
                 rs189678245 
                 A 
                 G 
                 ATP2C2 
                 D 
                 3.62 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 16 
                 84482136 
                 rs138818397 
                 A 
                 G 
                 ATP2C2 
                 . 
                 3.62 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.0089 
               
               
                   
               
               
                 4 
                 16 
                 84485620 
                 rs544756548 
                 C 
                 T 
                 ATP2C2 
                 D 
                 3.62 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 10429123 
                 rs187438258 
                 G 
                 A 
                 MYH2 
                 D 
                 3.62 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 17 
                 10432499 
                 rs150830535 
                 T 
                 C 
                 MYH2 
                 D 
                 3.62 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 17 
                 10541353 
                 rs201166774 
                 G 
                 A 
                 MYH3 
                 . 
                 1.81 
                 . 
                 264 
                 232 
                 0 
                 4 
                 4 
                 0.006 
               
               
                   
               
               
                 4 
                 17 
                 10558169 
                 rs374786690 
                 G 
                 C 
                 MYH3 
                 . 
                 1.81 
                 . 
                 264 
                 232 
                 0 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 17 
                 15554781 
                 rs140413277 
                 G 
                 T 
                 TRIM16 
                 . 
                 1.81 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0089 
               
               
                   
               
               
                 4 
                 17 
                 19246867 
                 rs7221577 
                 T 
                 C 
                 B9D1 
                 . 
                 6.34 
                 1.99 
                 396 
                 348 
                 4 
                 7 
                 7 
                 0.0079 
               
               
                   
               
               
                 4 
                 17 
                 19246919 
                 rs556859873 
                 G 
                 T 
                 B9D1 
                 . 
                 6.34 
                 1.99 
                 396 
                 348 
                 4 
                 7 
                 7 
                 0.005 
               
               
                   
               
               
                 4 
                 17 
                 19247075 
                 rs4924987 
                 G 
                 A 
                 B9D1 
                 . 
                 6.34 
                 1.99 
                 396 
                 348 
                 4 
                 7 
                 7 
                 0.004 
               
               
                   
               
               
                 4 
                 17 
                 26856125 
                 rs188424977 
                 G 
                 A 
                 FOXN1 
                 D 
                 1.81 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 17 
                 26861343 
                 rs200401045 
                 C 
                 T 
                 FOXN1 
                 . 
                 1.81 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 26864171 
                 rs187814037 
                 C 
                 T 
                 FOXN1 
                 D 
                 1.81 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.005 
               
               
                   
               
               
                 4 
                 17 
                 27233472 
                 rs200441251 
                 T 
                 C 
                 PHF12 
                 D 
                 1.81 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 27234599 
                 rs368783828 
                 G 
                 A 
                 PHF12 
                 . 
                 1.81 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 27240924 
                 rs189300962 
                 G 
                 C 
                 PHF12 
                 D 
                 1.81 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 17 
                 29226507 
                 rs201170896 
                 C 
                 T 
                 TEFM 
                 D 
                 7.24 
                 1.52 
                 132 
                 116 
                 3 
                 4 
                 4 
                 0.004 
               
               
                   
               
               
                 4 
                 17 
                 3417212 
                 rs547743528 
                 T 
                 C 
                 TRPV3 
                 . 
                 2.72 
                 3.41 
                 264 
                 232 
                 1 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 3417877 
                 rs112791047 
                 G 
                 A 
                 TRPV3 
                 . 
                 2.72 
                 3.41 
                 264 
                 232 
                 1 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 17 
                 38792637 
                 rs199790447 
                 C 
                 G 
                 SMARCE1 
                 . 
                 1.81 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 17 
                 38975376 
                 rs565976410 
                 C 
                 G 
                 KRT10 
                 D 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 17 
                 38977344 
                 rs200239146 
                 G 
                 A 
                 KRT10 
                 D 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 39884092 
                 . 
                 G 
                 A 
                 HAP1 
                 . 
                 5.43 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 17 
                 39890576 
                 . 
                 C 
                 T 
                 HAP1 
                 . 
                 5.43 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.006 
               
               
                   
               
               
                 4 
                 17 
                 46878711 
                 rs184362955 
                 G 
                 A 
                 TTLL6 
                 D 
                 5.43 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 5347841 
                 rs192062270 
                 G 
                 A 
                 DHX33 
                 . 
                 1.81 
                 3.98 
                 396 
                 348 
                 2 
                 7 
                 7 
                 0.004 
               
               
                   
               
               
                 4 
                 17 
                 5364438 
                 rs192014491 
                 G 
                 A 
                 DHX33 
                 . 
                 1.81 
                 3.98 
                 396 
                 348 
                 2 
                 7 
                 7 
                 0.003 
               
               
                   
               
               
                 4 
                 17 
                 5371883 
                 rs16954727 
                 C 
                 G 
                 DHX33 
                 . 
                 1.81 
                 3.98 
                 396 
                 348 
                 2 
                 7 
                 7 
                 0.0099 
               
               
                   
               
               
                 4 
                 17 
                 64216866 
                 rs181936071 
                 A 
                 C 
                 APOH 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.0069 
               
               
                   
               
               
                 4 
                 17 
                 64219860 
                 rs373658444 
                 CA 
                 C 
                 APOH 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.0069 
               
               
                   
               
               
                 4 
                 17 
                 6546267 
                 rs145492116 
                 A 
                 G 
                 TXNDC17 
                 . 
                 5.43 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 17 
                 67079395 
                 rs117323775 
                 G 
                 T 
                 ABCA6 
                 D 
                 1.63 
                 1.64 
                 254 
                 232 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 67121109 
                 rs200376492 
                 A 
                 G 
                 ABCA6 
                 D 
                 1.63 
                 1.64 
                 254 
                 232 
                 2 
                 3 
                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 17 
                 67246623 
                 rs559974558 
                 G 
                 A 
                 ABCA5 
                 D 
                 2.9 
                 1.5 
                 652 
                 580 
                 6 
                 8 
                 8 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 67247973 
                 rs201343208 
                 G 
                 A 
                 ABCA5 
                 D 
                 2.9 
                 1.5 
                 652 
                 580 
                 6 
                 8 
                 8 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 67250466 
                 rs199641093 
                 C 
                 T 
                 ABCA5 
                 D 
                 2.9 
                 1.5 
                 652 
                 580 
                 6 
                 8 
                 8 
                 0.004 
               
               
                   
               
               
                 4 
                 17 
                 67299017 
                 rs201944918 
                 A 
                 G 
                 ABCA5 
                 D 
                 2.9 
                 1.5 
                 652 
                 580 
                 6 
                 8 
                 8 
                 0.0079 
               
               
                   
               
               
                 4 
                 17 
                 67305519 
                 rs199888749 
                 G 
                 A 
                 ABCA5 
                 D 
                 2.9 
                 1.5 
                 652 
                 580 
                 6 
                 8 
                 8 
                 0.0079 
               
               
                   
               
               
                 4 
                 17 
                 73827216 
                 rs140184929 
                 C 
                 T 
                 UNC13D 
                 D 
                 5.43 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.006 
               
               
                   
               
               
                 4 
                 17 
                 73839609 
                 rs527842266 
                 C 
                 G 
                 UNC13D 
                 . 
                 5.43 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 17 
                 7701543 
                 rs141742705 
                 G 
                 A 
                 DNAH2 
                 D 
                 1.81 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 7705344 
                 rs8073196 
                 G 
                 C 
                 DNAH2 
                 . 
                 1.81 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 7736250 
                 rs201527036 
                 G 
                 A 
                 DNAH2 
                 . 
                 1.81 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 79684531 
                 rs201577202 
                 C 
                 T 
                 SLC25A10 
                 . 
                 3.62 
                 1.52 
                 264 
                 232 
                 3 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 79684871 
                 rs77609145 
                 A 
                 T 
                 SLC25A10 
                 D 
                 3.62 
                 1.52 
                 264 
                 232 
                 3 
                 4 
                 4 
                 0.006 
               
               
                   
               
               
                 4 
                 18 
                 2707800 
                 rs184984483 
                 C 
                 T 
                 SMCHD1 
                 . 
                 5.48 
                 3.37 
                 258 
                 230 
                 1 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 18 
                 2777922 
                 rs527648000 
                 C 
                 T 
                 SMCHD1 
                 . 
                 5.48 
                 3.37 
                 258 
                 230 
                 1 
                 3 
                 3 
                 0.005 
               
               
                   
               
               
                 4 
                 18 
                 28911778 
                 rs147775289 
                 T 
                 C 
                 DSG1 
                 D 
                 5.43 
                 1.71 
                 528 
                 464 
                 2 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 18 
                 28934293 
                 rs149191001 
                 C 
                 T 
                 DSG1 
                 D 
                 5.43 
                 1.71 
                 528 
                 464 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 18 
                 28934674 
                 rs181411154 
                 G 
                 A 
                 DSG1 
                 D 
                 5.43 
                 1.71 
                 528 
                 464 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 18 
                 28934927 
                 rs148488583 
                 C 
                 G 
                 DSG1 
                 D 
                 5.43 
                 1.71 
                 528 
                 464 
                 2 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 18 
                 580853 
                 rs114933134 
                 G 
                 A 
                 CETN1 
                 D 
                 3.62 
                 . 
                 132 
                 116 
                 0 
                 4 
                 4 
                 0.005 
               
               
                   
               
               
                 4 
                 18 
                 61160178 
                 rs370525785 
                 T 
                 C 
                 SERPINB5 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 18 
                 61170818 
                 rs185364126 
                 G 
                 A 
                 SERPINB5 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 18 
                 61305002 
                 rs201297323 
                 T 
                 C 
                 SERPINB4 
                 D 
                 1.81 
                 3.41 
                 264 
                 232 
                 1 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 18 
                 61305289 
                 rs188021365 
                 A 
                 T 
                 SERPINB4 
                 . 
                 1.81 
                 3.41 
                 264 
                 232 
                 1 
                 3 
                 3 
                 0.005 
               
               
                   
               
               
                 4 
                 1 
                 87380851 
                 rs546745 
                 A 
                 G 
                 HS2ST1 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 1 
                 87563514 
                 rs143260332 
                 G 
                 A 
                 HS2ST1 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 18 
                 76886315 
                 rs200431802 
                 C 
                 T 
                 ATP9B 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 18 
                 77096664 
                 rs201172611 
                 G 
                 A 
                 ATP9B 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 18 
                 9549345 
                 rs199964908 
                 G 
                 A 
                 PPP4R1 
                 . 
                 2.72 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 19 
                 14071095 
                 rs140301367 
                 G 
                 A 
                 DCAF15 
                 . 
                 5.43 
                 3.41 
                 132 
                 116 
                 1 
                 3 
                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 19 
                 15285063 
                 rs141320511 
                 G 
                 T 
                 NOTCH3 
                 D 
                 4.53 
                 5.69 
                 396 
                 348 
                 1 
                 5 
                 5 
                 0.0099 
               
               
                   
               
               
                 4 
                 19 
                 15298126 
                 rs201118034 
                 G 
                 A 
                 NOTCH3 
                 D 
                 4.53 
                 5.69 
                 396 
                 348 
                 1 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 19 
                 15302951 
                 rs202157633 
                 G 
                 A 
                 NOTCH3 
                 D 
                 4.53 
                 5.69 
                 396 
                 348 
                 1 
                 5 
                 5 
                 0.005 
               
               
                   
               
               
                 4 
                 19 
                 39367429 
                 rs58188607 
                 G 
                 A 
                 RINL 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 19 
                 44662139 
                 rs201230189 
                 G 
                 A 
                 ZNF234 
                 D 
                 1.81 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 19 
                 41837123 
                 rs199982059 
                 C 
                 T 
                 TGFβ1 
                 . 
                 1.81 
                 . 
                 132 
                 116 
                 0 
                 4 
                 4 
                 0.006 
               
               
                   
               
               
                 4 
                 19 
                 46184983 
                 rs186639840 
                 A 
                 T 
                 GIPR 
                 . 
                 1.81 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0069 
               
               
                   
               
               
                 4 
                 19 
                 46242968 
                 rs183304235 
                 G 
                 C 
                 BHMG1 
                 D 
                 2.72 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 19 
                 51470542 
                 rs201586262 
                 G 
                 T 
                 KLK6 
                 D 
                 5.43 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 1 
                 95303290 
                 rs140889980 
                 G 
                 A 
                 SLC44A3 
                 D 
                 1.81 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 1 
                 95322899 
                 rs184943086 
                 C 
                 T 
                 SLC44A3 
                 . 
                 1.81 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 19 
                 8140232 
                 rs145316149 
                 G 
                 A 
                 FBN3 
                 D 
                 1.81 
                 3.41 
                 528 
                 464 
                 1 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 19 
                 8150331 
                 rs142940013 
                 G 
                 A 
                 FBN3 
                 D 
                 1.81 
                 3.41 
                 528 
                 464 
                 1 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 19 
                 8155130 
                 rs183278638 
                 G 
                 A 
                 FBN3 
                 D 
                 1.81 
                 3.41 
                 528 
                 464 
                 1 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 19 
                 8188820 
                 rs145435433 
                 C 
                 T 
                 FBN3 
                 D 
                 1.81 
                 3.41 
                 528 
                 464 
                 1 
                 3 
                 3 
                 0.006 
               
               
                   
               
               
                 4 
                 19 
                 8979212 
                 rs149481309 
                 C 
                 T 
                 MUC16 
                 . 
                 3.62 
                 1.82 
                 528 
                 464 
                 5 
                 8 
                 8 
                 0.0089 
               
               
                   
               
               
                 4 
                 19 
                 9002496 
                 rs553074376 
                 C 
                 T 
                 MUC16 
                 . 
                 3.62 
                 1.82 
                 528 
                 464 
                 5 
                 8 
                 8 
                 0.006 
               
               
                   
               
               
                 4 
                 19 
                 9043416 
                 rs17417801 
                 G 
                 A 
                 MUC16 
                 . 
                 3.62 
                 1.82 
                 528 
                 464 
                 5 
                 8 
                 8 
                 0.0079 
               
               
                   
               
               
                 4 
                 19 
                 9056878 
                 rs200934751 
                 GAGA 
                 G 
                 MUC16 
                 . 
                 3.62 
                 1.82 
                 528 
                 464 
                 5 
                 8 
                 8 
                 0.0069 
               
               
                   
               
               
                 4 
                 20 
                 23433244 
                 rs146114915 
                 G 
                 A 
                 CST11 
                 . 
                 5.43 
                 3.41 
                 132 
                 116 
                 1 
                 3 
                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 20 
                 34117097 
                 rs141795719 
                 G 
                 A 
                 C20orf173 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 20 
                 37394884 
                 rs141204447 
                 G 
                 A 
                 ACTR5 
                 D 
                 6.34 
                 7.97 
                 264 
                 232 
                 1 
                 7 
                 7 
                 0.0069 
               
               
                   
               
               
                 4 
                 20 
                 37400374 
                 rs3752289 
                 C 
                 T 
                 ACTR5 
                 D 
                 6.34 
                 7.97 
                 264 
                 232 
                 1 
                 7 
                 7 
                 0.0089 
               
               
                   
               
               
                 4 
                 20 
                 39788407 
                 rs201733074 
                 T 
                 C 
                 PLCG1 
                 . 
                 1.81 
                 6.83 
                 396 
                 348 
                 1 
                 6 
                 6 
                 0.0079 
               
               
                   
               
               
                 4 
                 20 
                 39797820 
                 rs547025579 
                 GACCAGAA 
                 G 
                 PLCG1 
                 . 
                 1.81 
                 6.83 
                 396 
                 348 
                 1 
                 6 
                 6 
                 0.0069 
               
               
                   
                   
                   
                   
                 CC 
               
               
                   
                   
                   
                   
                 (SEQ ID 
               
               
                   
                   
                   
                   
                 NO: 1) 
               
               
                   
               
               
                 4 
                 20 
                 39798092 
                 rs183538599 
                 C 
                 T 
                 PLCG1 
                 . 
                 1.81 
                 6.83 
                 396 
                 348 
                 1 
                 6 
                 6 
                 0.0079 
               
               
                   
               
               
                 4 
                 20 
                 39974514 
                 rs201526389 
                 C 
                 T 
                 LPIN3 
                 D 
                 3.62 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.0079 
               
               
                   
               
               
                 4 
                 20 
                 39981270 
                 rs200870645 
                 C 
                 G 
                 LPIN3 
                 D 
                 3.62 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 20 
                 39987396 
                 rs202035187 
                 T 
                 C 
                 LPIN3 
                 D 
                 3.62 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 20 
                 40052247 
                 rs569454917 
                 C 
                 G 
                 CHD6 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 20 
                 40161851 
                 rs75576471 
                 C 
                 G 
                 CHD6 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.0069 
               
               
                   
               
               
                 4 
                 20 
                 45839488 
                 rs144592314 
                 G 
                 A 
                 ZMYND8 
                 D 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 2 
                 101093702 
                 rs149056157 
                 C 
                 T 
                 NMS 
                 . 
                 1.81 
                 . 
                 132 
                 116 
                 0 
                 5 
                 5 
                 0.0079 
               
               
                   
               
               
                 4 
                 2 
                 11295694 
                 rs372049512 
                 C 
                 A 
                 PQLC3 
                 D 
                 1.81 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 2 
                 118577378 
                 rs145263993 
                 A 
                 C 
                 DDX18 
                 . 
                 5.43 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 21 
                 34018908 
                 rs115353088 
                 A 
                 T 
                 SYNJ1 
                 D 
                 2.41 
                 2.26 
                 394 
                 348 
                 2 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 21 
                 34045841 
                 rs115989459 
                 G 
                 A 
                 SYNJ1 
                 D 
                 2.41 
                 2.26 
                 394 
                 348 
                 2 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 21 
                 34048669 
                 rs533995497 
                 T 
                 C 
                 SYNJ1 
                 . 
                 2.41 
                 2.26 
                 394 
                 348 
                 2 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 21 
                 38072227 
                 rs200569203 
                 G 
                 A 
                 SIM2 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 21 
                 38098456 
                 rs201356831 
                 T 
                 C 
                 SIM2 
                 D 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 141115543 
                 rs77178150 
                 C 
                 T 
                 LRP1B 
                 . 
                 2.72 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.0089 
               
               
                   
               
               
                 4 
                 2 
                 141253160 
                 rs572325724 
                 T 
                 A 
                 LRP1B 
                 D 
                 2.72 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 2 
                 141458125 
                 rs369842040 
                 G 
                 A 
                 LRP1B 
                 D 
                 2.72 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 21 
                 47571485 
                 rs199508525 
                 C 
                 T 
                 FTCD 
                 D 
                 1.81 
                 3.41 
                 132 
                 116 
                 1 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 2 
                 178534249 
                 rs142433460 
                 T 
                 A 
                 PDE11A 
                 D 
                 7.24 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.004 
               
               
                   
               
               
                 4 
                 2 
                 178562138 
                 rs201572288 
                 A 
                 T 
                 PDE11A 
                 D 
                 7.24 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 2 
                 179404792 
                 rs556524594 
                 C 
                 T 
                 TTN 
                 . 
                 3.02 
                 1.9 
                 1056 
                 928 
                 3 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 179425208 
                 rs142478636 
                 G 
                 T 
                 TTN 
                 D 
                 3.02 
                 1.9 
                 1056 
                 928 
                 3 
                 5 
                 5 
                 0.004 
               
               
                   
               
               
                 4 
                 2 
                 179430305 
                 rs185887755 
                 G 
                 A 
                 TTN 
                 D 
                 3.02 
                 1.9 
                 1056 
                 928 
                 3 
                 5 
                 5 
                 0.003 
               
               
                   
               
               
                 4 
                 2 
                 179437342 
                 rs567446185 
                 C 
                 T 
                 TTN 
                 D 
                 3.02 
                 1.9 
                 1056 
                 928 
                 3 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 179481839 
                 rs144688960 
                 C 
                 A 
                 TTN 
                 . 
                 3.02 
                 1.9 
                 1056 
                 928 
                 3 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 179504772 
                 rs551963261 
                 C 
                 T 
                 TTN 
                 . 
                 3.02 
                 1.9 
                 1056 
                 928 
                 3 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 179577222 
                 rs186857044 
                 C 
                 A 
                 TTN 
                 D 
                 3.02 
                 1.9 
                 1056 
                 928 
                 3 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 179585717 
                 rs367826445 
                 C 
                 T 
                 TTN 
                 D 
                 3.02 
                 1.9 
                 1056 
                 928 
                 3 
                 5 
                 5 
                 0.002 
               
               
                   
               
               
                 4 
                 2 
                 196718225 
                 rs139835496 
                 G 
                 A 
                 DNAH7 
                 . 
                 2.72 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
                 0.005 
               
               
                   
               
               
                 4 
                 2 
                 202356803 
                 rs557048083 
                 G 
                 A 
                 ALS2CR11 
                 . 
                 2.72 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 202467972 
                 rs148342903 
                 C 
                 G 
                 ALS2CR11 
                 D 
                 2.72 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 2 
                 203058233 
                 rs13024221 
                 T 
                 C 
                 KIAA2012 
                 . 
                 7.3 
                 4.59 
                 264 
                 230 
                 1 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 2 
                 203059076 
                 rs141298049 
                 G 
                 A 
                 KIAA2012 
                 . 
                 7.3 
                 4.59 
                 264 
                 230 
                 1 
                 4 
                 4 
                 0.006 
               
               
                   
               
               
                 4 
                 2 
                 208477907 
                 rs192886645 
                 G 
                 A 
                 METTL21A 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 2 
                 213921827 
                 rs150075012 
                 T 
                 C 
                 IKZF2 
                 . 
                 2.72 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.0089 
               
               
                   
               
               
                 4 
                 2 
                 219029361 
                 rs201920477 
                 C 
                 T 
                 CXCR1 
                 D 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 22 
                 19864729 
                 rs146133764 
                 G 
                 A 
                 TXNRD2 
                 D 
                 2.72 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 22 
                 19868190 
                 rs184640901 
                 C 
                 G 
                 TXNRD2 
                 . 
                 2.72 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 22 
                 19870857 
                 rs147383232 
                 G 
                 A 
                 TXNRD2 
                 . 
                 2.72 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.0089 
               
               
                   
               
               
                 4 
                 22 
                 26159232 
                 rs79294358 
                 C 
                 T 
                 MYO18B 
                 D 
                 2.41 
                 4.55 
                 396 
                 348 
                 1 
                 4 
                 4 
                 0.0079 
               
               
                   
               
               
                 4 
                 22 
                 26166958 
                 rs117430010 
                 C 
                 T 
                 MYO18B 
                 . 
                 2.41 
                 4.55 
                 396 
                 348 
                 1 
                 4 
                 4 
                 0.006 
               
               
                   
               
               
                 4 
                 22 
                 26264278 
                 rs137859315 
                 T 
                 C 
                 MYO18B 
                 . 
                 2.41 
                 4.55 
                 396 
                 348 
                 1 
                 4 
                 4 
                 0.0079 
               
               
                   
               
               
                 4 
                 2 
                 227872169 
                 rs192411379 
                 T 
                 C 
                 COL4A4 
                 D 
                 2.72 
                 3.4 
                 526 
                 464 
                 1 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 227920837 
                 rs199710625 
                 A 
                 G 
                 COL4A4 
                 . 
                 2.72 
                 3.4 
                 526 
                 464 
                 1 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 2 
                 227967506 
                 rs373741172 
                 C 
                 T 
                 COL4A4 
                 D 
                 2.72 
                 3.4 
                 526 
                 464 
                 1 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 227985873 
                 rs190570269 
                 G 
                 C 
                 COL4A4 
                 . 
                 2.72 
                 3.4 
                 526 
                 464 
                 1 
                 3 
                 3 
                 0.006 
               
               
                   
               
               
                 4 
                 22 
                 29881766 
                 rs201416955 
                 G 
                 A 
                 NEFH 
                 D 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 22 
                 29881844 
                 rs117036372 
                 G 
                 A 
                 NEFH 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 22 
                 31522450 
                 rs150976596 
                 G 
                 A 
                 INPP5J 
                 D 
                 3.62 
                 1.9 
                 264 
                 232 
                 3 
                 5 
                 5 
                 0.0099 
               
               
                   
               
               
                 4 
                 22 
                 31522715 
                 rs370874308 
                 A 
                 T 
                 INPP5J 
                 . 
                 3.62 
                 1.9 
                 264 
                 232 
                 3 
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                 5 
                 0.003 
               
               
                   
               
               
                 4 
                 22 
                 32614713 
                 rs78144589 
                 C 
                 T 
                 SLC5A4 
                 . 
                 5.43 
                 6.83 
                 264 
                 232 
                 1 
                 6 
                 6 
                 0.0099 
               
               
                   
               
               
                 4 
                 22 
                 32631002 
                 rs554791323 
                 T 
                 C 
                 SLC5A4 
                 D 
                 5.43 
                 6.83 
                 264 
                 232 
                 1 
                 6 
                 6 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 234835171 
                 rs188545335 
                 G 
                 A 
                 TRPM8 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
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                 234890409 
                 rs202160114 
                 T 
                 C 
                 TRPM8 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
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                 242046783 
                 rs199503351 
                 G 
                 A 
                 PASK 
                 . 
                 5.43 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
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                 242047581 
                 rs563432464 
                 C 
                 A 
                 PASK 
                 . 
                 5.43 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
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                 242089016 
                 rs187718988 
                 G 
                 C 
                 PASK 
                 . 
                 5.43 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 242695306 
                 rs149628174 
                 C 
                 T 
                 D2HGDH 
                 D 
                 4.53 
                 2.84 
                 132 
                 116 
                 2 
                 5 
                 5 
                 0.0099 
               
               
                   
               
               
                 4 
                 22 
                 43926729 
                 rs201816198 
                 C 
                 A 
                 EFCAB6 
                 D 
                 1.63 
                 3.41 
                 264 
                 232 
                 1 
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                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 22 
                 44030977 
                 rs181939688 
                 G 
                 C 
                 EFCAB6 
                 . 
                 1.63 
                 3.41 
                 264 
                 232 
                 1 
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                 3 
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                 22 
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                 A 
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                 TTC38 
                 . 
                 3.62 
                 . 
                 264 
                 232 
                 0 
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                 4 
                 0.0099 
               
               
                   
               
               
                 4 
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                 46684376 
                 rs202139216 
                 C 
                 T 
                 TTC38 
                 . 
                 3.62 
                 . 
                 264 
                 232 
                 0 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 22 
                 51041663 
                 rs41282359 
                 C 
                 A 
                 MAPK8IP2 
                 . 
                 4.53 
                 2.84 
                 924 
                 812 
                 2 
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                 5 
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                 4 
                 22 
                 51042484 
                 rs56314791 
                 C 
                 T 
                 MAPK8IP2 
                 . 
                 4.53 
                 2.84 
                 924 
                 812 
                 2 
                 5 
                 5 
                 0.002 
               
               
                   
               
               
                 4 
                 22 
                 51042861 
                 rs9616795 
                 C 
                 G 
                 MAPK8IP2 
                 . 
                 4.53 
                 2.84 
                 924 
                 812 
                 2 
                 5 
                 5 
                 0.004 
               
               
                   
               
               
                 4 
                 22 
                 51042864 
                 rs571810591 
                 G 
                 C 
                 MAPK8IP2 
                 . 
                 4.53 
                 2.84 
                 924 
                 812 
                 2 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 22 
                 51043374 
                 rs550444582 
                 G 
                 A 
                 MAPK8IP2 
                 . 
                 4.53 
                 2.84 
                 924 
                 812 
                 2 
                 5 
                 5 
                 0.002 
               
               
                   
               
               
                 4 
                 22 
                 51044243 
                 rs916005 
                 C 
                 T 
                 MAPK8IP2 
                 . 
                 4.53 
                 2.84 
                 924 
                 812 
                 2 
                 5 
                 5 
                 0.004 
               
               
                   
               
               
                 4 
                 22 
                 51045178 
                 rs200208943 
                 C 
                 T 
                 MAPK8IP2 
                 . 
                 4.53 
                 2.84 
                 924 
                 812 
                 2 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
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                 27721143 
                 rs146175795 
                 G 
                 A 
                 GCKR 
                 D 
                 5.43 
                 3.41 
                 264 
                 232 
                 1 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
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                 27730834 
                 rs200225266 
                 C 
                 T 
                 GCKR 
                 . 
                 5.43 
                 3.41 
                 264 
                 232 
                 1 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
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                 31751329 
                 rs9332966 
                 G 
                 C 
                 SRD5A2 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
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                 2 
                 0.005 
               
               
                   
               
               
                 4 
                 2 
                 31805775 
                 rs550866120 
                 C 
                 T 
                 SRD5A2 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
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                 46588019 
                 rs150877473 
                 C 
                 G 
                 EPAS1 
                 . 
                 2.72 
                 3.41 
                 264 
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                 3 
                 0.0099 
               
               
                   
               
               
                 4 
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                 46603672 
                 rs187543960 
                 C 
                 G 
                 EPAS1 
                 . 
                 2.72 
                 3.41 
                 264 
                 232 
                 1 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 2 
                 65571844 
                 rs182442107 
                 T 
                 C 
                 SPRED2 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 2 
                 98165911 
                 rs1839230 
                 T 
                 C 
                 ANKRD36B 
                 . 
                 3.62 
                 . 
                 132 
                 116 
                 0 
                 4 
                 4 
                 0.0069 
               
               
                   
               
               
                 4 
                 3 
                 108147410 
                 rs552849827 
                 T 
                 C 
                 MYH15 
                 D 
                 3.02 
                 1.86 
                 518 
                 464 
                 3 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 3 
                 108178230 
                 rs560378764 
                 G 
                 A 
                 MYH15 
                 D 
                 3.02 
                 1.86 
                 518 
                 464 
                 3 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 3 
                 108219046 
                 rs182324086 
                 C 
                 A 
                 MYH15 
                 D 
                 3.02 
                 1.86 
                 518 
                 464 
                 3 
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                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 3 
                 108220556 
                 rs368131843 
                 C 
                 T 
                 MYH15 
                 . 
                 3.02 
                 1.86 
                 518 
                 464 
                 3 
                 5 
                 5 
                 0.006 
               
               
                   
               
               
                 4 
                 3 
                 121713035 
                 rs142746163 
                 G 
                 A 
                 ILDR1 
                 . 
                 1.81 
                 . 
                 264 
                 232 
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                 3 
                 3 
                 0.0099 
               
               
                   
               
               
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                 3 
                 121724081 
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                 C 
                 G 
                 ILDR1 
                 . 
                 1.81 
                 . 
                 264 
                 232 
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                 3 
                 3 
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                 124485068 
                 rs200221434 
                 C 
                 T 
                 ITGB5 
                 . 
                 2.72 
                 . 
                 396 
                 348 
                 0 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 3 
                 124492606 
                 rs140023830 
                 G 
                 A 
                 ITGB5 
                 D 
                 2.72 
                 . 
                 396 
                 348 
                 0 
                 3 
                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 3 
                 124567399 
                 rs28372859 
                 T 
                 A 
                 ITGB5 
                 D 
                 2.72 
                 . 
                 396 
                 348 
                 0 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 3 
                 124716667 
                 rs181022733 
                 G 
                 T 
                 HEG1 
                 D 
                 7.24 
                 2.28 
                 396 
                 348 
                 2 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 3 
                 124731800 
                 rs183321802 
                 T 
                 A 
                 HEG1 
                 D 
                 7.24 
                 2.28 
                 396 
                 348 
                 2 
                 4 
                 4 
                 0.004 
               
               
                   
               
               
                 4 
                 3 
                 124738285 
                 rs200164121 
                 G 
                 C 
                 HEG1 
                 D 
                 7.24 
                 2.28 
                 396 
                 348 
                 2 
                 4 
                 4 
                 0.0079 
               
               
                   
               
               
                 4 
                 3 
                 130120633 
                 rs370632529 
                 T 
                 G 
                 COL6A5 
                 D 
                 3.62 
                 1.52 
                 528 
                 464 
                 3 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 3 
                 130124457 
                 rs537224684 
                 A 
                 G 
                 COL6A5 
                 D 
                 3.62 
                 1.52 
                 528 
                 464 
                 3 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 3 
                 130145236 
                 rs202221090 
                 G 
                 A 
                 COL6A5 
                 D 
                 3.62 
                 1.52 
                 528 
                 464 
                 3 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 3 
                 130150614 
                 rs79358579 
                 C 
                 T 
                 COL6A5 
                 D 
                 3.62 
                 1.52 
                 528 
                 464 
                 3 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 3 
                 13420488 
                 rs200748145 
                 T 
                 C 
                 NUP210 
                 . 
                 5.43 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
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                 154861227 
                 rs2304504 
                 C 
                 T 
                 MME 
                 . 
                 5.43 
                 1.71 
                 396 
                 348 
                 2 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
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                 3 
                 154861228 
                 rs182602615 
                 G 
                 A 
                 MME 
                 . 
                 5.43 
                 1.71 
                 396 
                 348 
                 2 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 3 
                 154886310 
                 rs200308077 
                 G 
                 A 
                 MME 
                 D 
                 5.43 
                 1.71 
                 396 
                 348 
                 2 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 3 
                 183906578 
                 rs531703061 
                 C 
                 T 
                 ABCF3 
                 D 
                 5.43 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 3 
                 183911416 
                 rs76223160 
                 G 
                 A 
                 ABCF3 
                 D 
                 5.43 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.006 
               
               
                   
               
               
                 4 
                 3 
                 183952934 
                 rs374722127 
                 C 
                 T 
                 VWA5B2 
                 . 
                 2.41 
                 1.52 
                 264 
                 232 
                 3 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 3 
                 183957472 
                 rs565285822 
                 C 
                 T 
                 VWA5B2 
                 . 
                 2.41 
                 1.52 
                 264 
                 232 
                 3 
                 4 
                 4 
                 0.0089 
               
               
                   
               
               
                 4 
                 3 
                 186937924 
                 rs3774266 
                 C 
                 T 
                 MASP1 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 3 
                 186953975 
                 rs72549155 
                 G 
                 C 
                 MASP1 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 3 
                 2928719 
                 rs184171731 
                 A 
                 C 
                 CNTN4 
                 . 
                 4.53 
                 5.69 
                 396 
                 348 
                 1 
                 5 
                 5 
                 0.003 
               
               
                   
               
               
                 4 
                 3 
                 3080611 
                 rs10510251 
                 G 
                 C 
                 CNTN4 
                 . 
                 4.53 
                 5.69 
                 396 
                 348 
                 1 
                 5 
                 5 
                 0.003 
               
               
                   
               
               
                 4 
                 3 
                 3081959 
                 rs339284 
                 T 
                 C 
                 CNTN4 
                 . 
                 4.53 
                 5.69 
                 396 
                 348 
                 1 
                 5 
                 5 
                 0.002 
               
               
                   
               
               
                 4 
                 3 
                 44762826 
                 rs181738022 
                 C 
                 T 
                 ZNF502 
                 D 
                 2.72 
                 3.41 
                 264 
                 232 
                 2 
                 6 
                 6 
                 0.0079 
               
               
                   
               
               
                 4 
                 3 
                 44762827 
                 rs185260708 
                 A 
                 T 
                 ZNF502 
                 D 
                 2.72 
                 3.41 
                 264 
                 232 
                 2 
                 6 
                 6 
                 0.0079 
               
               
                   
               
               
                 4 
                 3 
                 49850176 
                 rs192575536 
                 G 
                 A 
                 UBA7 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 3 
                 58107069 
                 rs76471260 
                 G 
                 A 
                 FLNB 
                 D 
                 2.41 
                 4.55 
                 396 
                 348 
                 1 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 3 
                 58109123 
                 rs199959926 
                 G 
                 C 
                 FLNB 
                 D 
                 2.41 
                 4.55 
                 396 
                 348 
                 1 
                 4 
                 4 
                 0.006 
               
               
                   
               
               
                 4 
                 3 
                 58134099 
                 rs143066905 
                 A 
                 G 
                 FLNB 
                 . 
                 2.41 
                 4.55 
                 396 
                 348 
                 1 
                 4 
                 4 
                 0.0099 
               
               
                   
               
               
                 4 
                 3 
                 62309627 
                 rs1881268 
                 G 
                 C 
                 C3orf14 
                 . 
                 1.81 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
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                 62317022 
                 rs186089632 
                 C 
                 A 
                 C3orf14 
                 . 
                 1.81 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
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                 4 
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                 15599021 
                 rs117667651 
                 C 
                 A 
                 CC2D2A 
                 . 
                 2.72 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
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                 4 
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                 16168246 
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                 C 
                 T 
                 TAPT1 
                 . 
                 2.9 
                 4.55 
                 132 
                 116 
                 1 
                 4 
                 4 
                 0.0099 
               
               
                   
               
               
                 4 
                 4 
                 17842302 
                 rs527561771 
                 TAA 
                 T 
                 NCAPG 
                 . 
                 2.76 
                 1.66 
                 126 
                 114 
                 2 
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                 3 
                 0.0079 
               
               
                   
               
               
                 4 
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                 26322320 
                 rs200707132 
                 A 
                 C 
                 RBPJ 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
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                 2 
                 0.0079 
               
               
                   
               
               
                 4 
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                 6596385 
                 rs3216941 
                 AC 
                 A 
                 MAN2B2 
                 . 
                 5.43 
                 3.41 
                 132 
                 116 
                 1 
                 3 
                 3 
                 0.006 
               
               
                   
               
               
                 4 
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                 674349 
                 rs376244258 
                 AC 
                 A 
                 MYL5 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
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                 84378118 
                 rs199634680 
                 A 
                 AT 
                 MRPS18C 
                 . 
                 1.84 
                 2.32 
                 132 
                 114 
                 1 
                 2 
                 2 
                 0.0079 
               
               
                   
               
               
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                 96762012 
                 rs144813590 
                 C 
                 G 
                 PDHA2 
                 D 
                 5.43 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 4 
                 983115 
                 rs143381873 
                 G 
                 A 
                 SLC26A1 
                 D 
                 3.62 
                 1.52 
                 528 
                 464 
                 3 
                 4 
                 4 
                 0.005 
               
               
                   
               
               
                 4 
                 4 
                 983342 
                 rs201608921 
                 C 
                 T 
                 SLC26A1 
                 D 
                 3.62 
                 1.52 
                 528 
                 464 
                 3 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 4 
                 983810 
                 rs563866785 
                 G 
                 A 
                 SLC26A1 
                 D 
                 3.62 
                 1.52 
                 528 
                 464 
                 3 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 4 
                 984938 
                 rs139024319 
                 G 
                 A 
                 SLC26A1 
                 D 
                 3.62 
                 1.52 
                 528 
                 464 
                 3 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 5 
                 106716975 
                 rs201008479 
                 G 
                 A 
                 EFNA5 
                 D 
                 2.41 
                 . 
                 132 
                 116 
                 0 
                 4 
                 4 
                 0.006 
               
               
                   
               
               
                 4 
                 5 
                 118862922 
                 rs190659146 
                 T 
                 C 
                 HSD17B4 
                 . 
                 3.62 
                 . 
                 132 
                 116 
                 0 
                 4 
                 4 
                 0.005 
               
               
                   
               
               
                 4 
                 5 
                 130815199 
                 rs187240567 
                 T 
                 C 
                 RAPGEF6 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 5 
                 130841167 
                 rs201819833 
                 G 
                 A 
                 RAPGEF6 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 5 
                 134102599 
                 rs200408238 
                 C 
                 G 
                 DDX46 
                 . 
                 2.41 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 5 
                 134143635 
                 rs200296518 
                 A 
                 G 
                 DDX46 
                 . 
                 2.41 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 4 
                 0.0069 
               
               
                   
               
               
                 4 
                 5 
                 137506607 
                 rs191895585 
                 G 
                 A 
                 BRD8 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.005 
               
               
                   
               
               
                 4 
                 5 
                 1495038 
                 rs201521332 
                 G 
                 A 
                 LPCAT1 
                 . 
                 5.53 
                 . 
                 126 
                 114 
                 0 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 5 
                 156675967 
                 rs34482255 
                 C 
                 T 
                 ITK 
                 D 
                 1.81 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.005 
               
               
                   
               
               
                 4 
                 5 
                 180477285 
                 rs200884524 
                 C 
                 T 
                 BTNL9 
                 . 
                 1.81 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 5 
                 180483533 
                 rs373494500 
                 T 
                 C 
                 BTNL9 
                 . 
                 1.81 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 5 
                 38337618 
                 rs376475358 
                 G 
                 A 
                 EGFLAM 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 5 
                 38425202 
                 rs201409353 
                 A 
                 G 
                 EGFLAM 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 5 
                 43675682 
                 rs80011859 
                 C 
                 A 
                 NNT 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 5 
                 43677914 
                 rs144007922 
                 C 
                 T 
                 NNT 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 5 
                 94245090 
                 rs543643285 
                 G 
                 GA 
                 MCTP1 
                 . 
                 11.05 
                 2.28 
                 260 
                 228 
                 6 
                 12 
                 12 
                 0.001 
               
               
                   
               
               
                 4 
                 5 
                 94259730 
                 rs555638017 
                 GAAAC 
                 G 
                 MCTP1 
                 . 
                 11.05 
                 2.28 
                 260 
                 228 
                 6 
                 12 
                 12 
                 0.006 
               
               
                   
               
               
                 4 
                 5 
                 95226800 
                 rs560418641 
                 C 
                 T 
                 ELL2 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 5 
                 95278698 
                 rs74836108 
                 G 
                 A 
                 ELL2 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.0069 
               
               
                   
               
               
                 4 
                 6 
                 106960382 
                 rs201789082 
                 G 
                 C 
                 AIM1 
                 D 
                 3.62 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.005 
               
               
                   
               
               
                 4 
                 6 
                 106968092 
                 rs371163103 
                 TC 
                 T 
                 AIM1 
                 . 
                 3.62 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 6 
                 106991468 
                 rs147230945 
                 G 
                 A 
                 AIM1 
                 D 
                 3.62 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 6 
                 110636694 
                 rs141656597 
                 T 
                 C 
                 METTL24 
                 . 
                 1.81 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0099 
               
               
                   
               
               
                 4 
                 6 
                 127899925 
                 rs141247870 
                 C 
                 T 
                 C6orf58 
                 . 
                 5.43 
                 3.41 
                 132 
                 116 
                 1 
                 3 
                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 6 
                 147014059 
                 rs192310446 
                 T 
                 C 
                 ADGB 
                 . 
                 1.81 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
                 0.006 
               
               
                   
               
               
                 4 
                 6 
                 149959701 
                 rs375809770 
                 AAAG 
                 A 
                 KATNA1 
                 . 
                 5.43 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
                 0.005 
               
               
                   
               
               
                 4 
                 6 
                 158454680 
                 rs147847428 
                 G 
                 A 
                 SYNJ2 
                 D 
                 2.41 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.0079 
               
               
                   
               
               
                 4 
                 6 
                 158516905 
                 rs202164985 
                 C 
                 G 
                 SYNJ2 
                 D 
                 2.41 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 6 
                 20113198 
                 rs199830796 
                 G 
                 A 
                 MBOAT1 
                 D 
                 5.43 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 6 
                 20118693 
                 rs553353326 
                 G 
                 A 
                 MBOAT1 
                 D 
                 5.43 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 6 
                 33134570 
                 . 
                 G 
                 A 
                 COL11A2 
                 D 
                 1.81 
                 3.79 
                 660 
                 580 
                 3 
                 10 
                 10 
                 0.006 
               
               
                   
               
               
                 4 
                 6 
                 33138929 
                 . 
                 G 
                 A 
                 COL11A2 
                 D 
                 1.81 
                 3.79 
                 660 
                 580 
                 3 
                 10 
                 10 
                 0.0099 
               
               
                   
               
               
                 4 
                 6 
                 33146518 
                 . 
                 A 
                 C 
                 COL11A2 
                 . 
                 1.81 
                 3.79 
                 660 
                 580 
                 3 
                 10 
                 10 
                 0.004 
               
               
                   
               
               
                 4 
                 6 
                 33147564 
                 . 
                 C 
                 A 
                 COL11A2 
                 D 
                 1.81 
                 3.79 
                 660 
                 580 
                 3 
                 10 
                 10 
                 0.001 
               
               
                   
               
               
                 4 
                 6 
                 33154514 
                 . 
                 C 
                 A 
                 COL11A2 
                 D 
                 1.81 
                 3.79 
                 660 
                 580 
                 3 
                 10 
                 10 
                 0.0089 
               
               
                   
               
               
                 4 
                 6 
                 35438350 
                 rs187631484 
                 C 
                 T 
                 MIR7111 
                 . 
                 2.72 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 6 
                 35438350 
                 rs187631484 
                 C 
                 T 
                 RPL10A 
                 . 
                 2.72 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 6 
                 39883802 
                 rs34757428 
                 A 
                 T 
                 MOCS1 
                 . 
                 5.73 
                 3.6 
                 132 
                 110 
                 1 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 6 
                 42933047 
                 rs187435179 
                 A 
                 G 
                 PEX6 
                 D 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0089 
               
               
                   
               
               
                 4 
                 6 
                 43160731 
                 rs568565110 
                 C 
                 G 
                 CUL9 
                 . 
                 5.43 
                 . 
                 396 
                 348 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 6 
                 43170522 
                 rs200509434 
                 G 
                 T 
                 CUL9 
                 D 
                 5.43 
                 . 
                 396 
                 348 
                 0 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 6 
                 43172581 
                 rs80345623 
                 G 
                 A 
                 CUL9 
                 D 
                 5.43 
                 . 
                 396 
                 348 
                 0 
                 3 
                 3 
                 0.0099 
               
               
                   
               
               
                 4 
                 6 
                 49416648 
                 rs199555550 
                 G 
                 A 
                 MUT 
                 . 
                 9.05 
                 5.32 
                 370 
                 348 
                 1 
                 5 
                 5 
                 0.0079 
               
               
                   
               
               
                 4 
                 6 
                 49425591 
                 rs200908035 
                 T 
                 C 
                 MUT 
                 D 
                 9.05 
                 5.32 
                 370 
                 348 
                 1 
                 5 
                 5 
                 0.0079 
               
               
                   
               
               
                 4 
                 6 
                 49425720 
                 rs528689712 
                 T 
                 C 
                 MUT 
                 D 
                 9.05 
                 5.32 
                 370 
                 348 
                 1 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 6 
                 72678681 
                 rs532652925 
                 C 
                 G 
                 RIMS1 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 6 
                 72974764 
                 rs564292772 
                 C 
                 A 
                 RIMS1 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 6 
                 76540124 
                 rs187811833 
                 C 
                 T 
                 MYO6 
                 . 
                 1.81 
                 . 
                 130 
                 116 
                 0 
                 3 
                 3 
                 0.0089 
               
               
                   
               
               
                 4 
                 6 
                 89977391 
                 rs146618576 
                 T 
                 C 
                 GABRR2 
                 . 
                 7.24 
                 3.03 
                 396 
                 348 
                 3 
                 8 
                 8 
                 0.002 
               
               
                   
               
               
                 4 
                 6 
                 89977789 
                 rs141423190 
                 A 
                 C 
                 GABRR2 
                 D 
                 7.24 
                 3.03 
                 396 
                 348 
                 3 
                 8 
                 8 
                 0.0079 
               
               
                   
               
               
                 4 
                 6 
                 89978946 
                 rs188424932 
                 G 
                 A 
                 GABRR2 
                 D 
                 7.24 
                 3.03 
                 396 
                 348 
                 3 
                 8 
                 8 
                 0.003 
               
               
                   
               
               
                 4 
                 7 
                 100357429 
                 rs374243234 
                 C 
                 T 
                 ZAN 
                 . 
                 1.81 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 7 
                 100363045 
                 rs184742914 
                 A 
                 T 
                 ZAN 
                 . 
                 1.81 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 7 
                 100389715 
                 rs369936309 
                 C 
                 T 
                 ZAN 
                 D 
                 1.81 
                 3.41 
                 396 
                 348 
                 1 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 7 
                 100656178 
                 rs74570695 
                 G 
                 A 
                 MUC12 
                 . 
                 2.72 
                 3.41 
                 132 
                 116 
                 1 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 7 
                 117144344 
                 rs1800073 
                 C 
                 T 
                 CFTR 
                 D 
                 3.62 
                 2.26 
                 654 
                 580 
                 2 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 7 
                 117171053 
                 rs141723617 
                 T 
                 C 
                 CFTR 
                 D 
                 3.62 
                 2.26 
                 654 
                 580 
                 2 
                 4 
                 4 
                 0.0079 
               
               
                   
               
               
                 4 
                 7 
                 117199578 
                 rs138427145 
                 A 
                 T 
                 CFTR 
                 D 
                 3.62 
                 2.26 
                 654 
                 580 
                 2 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 7 
                 117235045 
                 rs397508395 
                 G 
                 A 
                 CFTR 
                 D 
                 3.62 
                 2.26 
                 654 
                 580 
                 2 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 7 
                 117307076 
                 rs4148725 
                 C 
                 T 
                 CFTR 
                 D 
                 3.62 
                 2.26 
                 654 
                 580 
                 2 
                 4 
                 4 
                 0.006 
               
               
                   
               
               
                 4 
                 7 
                 131888058 
                 rs143605398 
                 TGCTAGGC 
                 T 
                 PLXNA4 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.0099 
               
               
                   
                   
                   
                   
                 CCCAGCC 
               
               
                   
                   
                   
                   
                 (SEQ ID 
               
               
                   
                   
                   
                   
                 NO: 2) 
               
               
                   
               
               
                 4 
                 7 
                 131888117 
                 rs181597184 
                 C 
                 T 
                 PLXNA4 
                 D 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 7 
                 139260038 
                 rs56338252 
                 T 
                 C 
                 HIPK2 
                 . 
                 2.41 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 7 
                 143017768 
                 rs201509501 
                 C 
                 T 
                 CLCN1 
                 D 
                 5.43 
                 3.41 
                 264 
                 232 
                 1 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 7 
                 143029550 
                 rs202119213 
                 C 
                 T 
                 CLCN1 
                 D 
                 5.43 
                 3.41 
                 264 
                 232 
                 1 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 7 
                 26678881 
                 rs78525926 
                 G 
                 A 
                 C7orf71 
                 . 
                 3.62 
                 . 
                 264 
                 232 
                 0 
                 4 
                 4 
                 0.004 
               
               
                   
               
               
                 4 
                 7 
                 26678910 
                 rs111516571 
                 C 
                 T 
                 C7orf71 
                 . 
                 3.62 
                 . 
                 264 
                 232 
                 0 
                 4 
                 4 
                 0.004 
               
               
                   
               
               
                 4 
                 7 
                 29535662 
                 rs3815512 
                 G 
                 C 
                 CHN2 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 7 
                 47342658 
                 rs192974657 
                 G 
                 A 
                 TNS3 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 7 
                 47454718 
                 rs187456873 
                 C 
                 T 
                 TNS3 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 7 
                 75192236 
                 . 
                 C 
                 A 
                 HIP1 
                 . 
                 3.62 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.0089 
               
               
                   
               
               
                 4 
                 7 
                 75210547 
                 . 
                 A 
                 T 
                 HIP1 
                 . 
                 3.62 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 8 
                 116426988 
                 rs181035264 
                 T 
                 A 
                 TRPS1 
                 D 
                 5.43 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 8 
                 116631783 
                 rs202001185 
                 T 
                 C 
                 TRPS1 
                 D 
                 5.43 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 8 
                 133900823 
                 rs368037086 
                 C 
                 T 
                 TG 
                 . 
                 1.84 
                 . 
                 260 
                 228 
                 0 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 8 
                 133981695 
                 rs189500765 
                 C 
                 T 
                 TG 
                 . 
                 1.84 
                 . 
                 260 
                 228 
                 0 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 8 
                 144895478 
                 . 
                 C 
                 A 
                 SCRIB 
                 . 
                 1.81 
                 4.55 
                 132 
                 116 
                 1 
                 4 
                 4 
                 0.006 
               
               
                   
               
               
                 4 
                 8 
                 145694225 
                 rs193131687 
                 C 
                 T 
                 KIFC2 
                 . 
                 5.43 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 8 
                 145736896 
                 rs557256260 
                 C 
                 T 
                 RECQL4 
                 . 
                 1.81 
                 1.71 
                 660 
                 580 
                 4 
                 6 
                 6 
                 0.001 
               
               
                   
               
               
                 4 
                 8 
                 145738985 
                 rs536831548 
                 G 
                 C 
                 RECQL4 
                 . 
                 1.81 
                 1.71 
                 660 
                 580 
                 4 
                 6 
                 6 
                 0.001 
               
               
                   
               
               
                 4 
                 8 
                 145741388 
                 rs200097701 
                 C 
                 G 
                 RECQL4 
                 . 
                 1.81 
                 1.71 
                 660 
                 580 
                 4 
                 6 
                 6 
                 0.005 
               
               
                   
               
               
                 4 
                 8 
                 145741602 
                 rs34633809 
                 C 
                 T 
                 RECQL4 
                 . 
                 1.81 
                 1.71 
                 660 
                 580 
                 4 
                 6 
                 6 
                 0.0089 
               
               
                   
               
               
                 4 
                 8 
                 145742799 
                 rs34642881 
                 T 
                 C 
                 RECQL4 
                 . 
                 1.81 
                 1.71 
                 660 
                 580 
                 4 
                 6 
                 6 
                 0.0079 
               
               
                   
               
               
                 4 
                 8 
                 17400906 
                 rs12680645 
                 G 
                 A 
                 SLC7A2 
                 D 
                 2.26 
                 2.84 
                 396 
                 348 
                 2 
                 5 
                 5 
                 0.0079 
               
               
                   
               
               
                 4 
                 8 
                 17407821 
                 rs188973136 
                 C 
                 G 
                 SLC7A2 
                 D 
                 2.26 
                 2.84 
                 396 
                 348 
                 2 
                 5 
                 5 
                 0.006 
               
               
                   
               
               
                 4 
                 8 
                 17417839 
                 rs201373242 
                 A 
                 G 
                 SLC7A2 
                 D 
                 2.26 
                 2.84 
                 396 
                 348 
                 2 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 8 
                 24771326 
                 rs182011677 
                 C 
                 G 
                 NEFM 
                 D 
                 2.72 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 8 
                 24775743 
                 rs557507354 
                 C 
                 T 
                 NEFM 
                 D 
                 2.72 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 8 
                 25293853 
                 rs2271114 
                 A 
                 G 
                 KCTD9 
                 . 
                 3.68 
                 2.25 
                 128 
                 114 
                 1 
                 2 
                 2 
                 0.005 
               
               
                   
               
               
                 4 
                 8 
                 41470357 
                 rs372694683 
                 C 
                 T 
                 GPAT4 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 8 
                 43155706 
                 rs182905752 
                 C 
                 T 
                 POTEA 
                 . 
                 3.68 
                 2.23 
                 254 
                 228 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 8 
                 43211970 
                 rs534445172 
                 A 
                 C 
                 POTEA 
                 . 
                 3.68 
                 2.23 
                 254 
                 228 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 8 
                 89086826 
                 rs200104505 
                 T 
                 A 
                 MMP16 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0099 
               
               
                   
               
               
                 4 
                 9 
                 136917570 
                 rs200913664 
                 G 
                 A 
                 BRD3 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0069 
               
               
                   
               
               
                 4 
                 9 
                 138235867 
                 rs531171616 
                 G 
                 A 
                 C9orf62 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 9 
                 138236230 
                 rs560393458 
                 T 
                 G 
                 C9orf62 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 9 
                 139008659 
                 rs373479265 
                 C 
                 T 
                 C9orf69 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 9 
                 139360706 
                 rs189523223 
                 C 
                 T 
                 SEC16A 
                 . 
                 7.24 
                 . 
                 264 
                 232 
                 0 
                 4 
                 4 
                 0.004 
               
               
                   
               
               
                 4 
                 9 
                 139372145 
                 rs192612248 
                 G 
                 T 
                 SEC16A 
                 . 
                 7.24 
                 . 
                 264 
                 232 
                 0 
                 4 
                 4 
                 0.005 
               
               
                   
               
               
                 4 
                 9 
                 15571614 
                 rs182199324 
                 T 
                 C 
                 CCDC171 
                 . 
                 3.62 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 9 
                 15745503 
                 rs530529615 
                 A 
                 T 
                 CCDC171 
                 . 
                 3.62 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 9 
                 15777828 
                 rs202139088 
                 T 
                 G 
                 CCDC171 
                 . 
                 3.62 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 9 
                 439392 
                 rs117109271 
                 A 
                 G 
                 DOCK8 
                 . 
                 1.81 
                 1.52 
                 264 
                 232 
                 3 
                 4 
                 4 
                 0.0099 
               
               
                   
               
               
                 4 
                 9 
                 441423 
                 rs188141951 
                 C 
                 T 
                 DOCK8 
                 . 
                 1.81 
                 1.52 
                 264 
                 232 
                 3 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 9 
                 5968714 
                 rs183413824 
                 C 
                 T 
                 KIAA2026 
                 D 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.005 
               
               
                   
               
               
                 4 
                 9 
                 72517162 
                 rs12344550 
                 T 
                 C 
                 C9orf135 
                 . 
                 3.62 
                 . 
                 264 
                 232 
                 0 
                 4 
                 4 
                 0.005 
               
               
                   
               
               
                 4 
                 9 
                 72517293 
                 rs11140833 
                 G 
                 T 
                 C9orf135 
                 . 
                 3.62 
                 . 
                 264 
                 232 
                 0 
                 4 
                 4 
                 0.005 
               
               
                   
               
               
                 4 
                 X 
                 8759354 
                 rs768509456 
                 A 
                 T 
                 FAM9A 
                 . 
                 3.69 
                 4.56 
                 262 
                 230 
                 1 
                 4 
                 4 
                 0.0013 
               
               
                   
               
               
                 4 
                 X 
                 8763309 
                 rs774169916 
                 GCTGCTGC 
                 G 
                 FAM9A 
                 . 
                 3.69 
                 4.56 
                 262 
                 230 
                 1 
                 4 
                 4 
                 0.0026 
               
               
                   
                   
                   
                   
                 TG 
               
               
                   
                   
                   
                   
                 CTGCGGCTT 
               
               
                   
                   
                   
                   
                 (SEQ ID 
               
               
                   
                   
                   
                   
                 NO: 3) 
               
               
                   
               
               
                 4 
                 X 
                 96136645 
                 rs778550013 
                 C 
                 T 
                 DIAPH2 
                 D 
                 3.66 
                 2.24 
                 260 
                 232 
                 2 
                 4 
                 3 
                 0.0013 
               
               
                   
               
               
                 5 
                 11 
                 17394037 
                 rs61406813 
                 CTT 
                 C 
                 NCR3LG1 
                 . 
                 5.43 
                 3.41 
                 132 
                 116 
                 2 
                 6 
                 5 
                 0.0089 
               
               
                   
               
               
                 5 
                 1 
                 21926063 
                 rs61014678 
                 C 
                 T 
                 RAP1GAP 
                 D 
                 7.24 
                 4.55 
                 264 
                 232 
                 2 
                 8 
                 7 
                 0.0069 
               
               
                   
               
               
                 5 
                 2 
                 113342071 
                 rs528909726 
                 G 
                 A 
                 CHCHD5 
                 . 
                 . 
                 . 
                 124 
                 90 
                 0 
                 2 
                 1 
                 0.002 
               
               
                   
               
               
                 5 
                 7 
                 139285351 
                 rs3735196 
                 C 
                 G 
                 HIPK2 
                 . 
                 2.41 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 3 
                 0.0089 
               
               
                   
               
               
                 5 
                 X 
                 96396659 
                 rs363755 
                 C 
                 T 
                 DIAPH2 
                 . 
                 3.66 
                 2.24 
                 260 
                 232 
                 2 
                 4 
                 3 
                 0.0052 
               
               
                   
               
               
                 6 
                 10 
                 126714641 
                 rs12571821 
                 G 
                 C 
                 CTBP2 
                 . 
                 1.81 
                 1.52 
                 132 
                 116 
                 3 
                 4 
                 4 
                 0.0446 
               
               
                   
               
               
                 6 
                 10 
                 28970433 
                 rs79472556 
                 G 
                 C 
                 BAMBI 
                 D 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.0159 
               
               
                   
               
               
                 6 
                 10 
                 28970914 
                 rs750723477 
                 C 
                 T 
                 BAMBI 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 10 
                 61956386 
                 rs34796699 
                 GA 
                 G 
                 ANK3 
                 . 
                 2.45 
                 1.6 
                 240 
                 236 
                 14 
                 22 
                 19 
                 . 
               
               
                   
               
               
                 6 
                 10 
                 61956386 
                 rs772920191 
                 G 
                 GAAA 
                 ANK3 
                 . 
                 2.45 
                 1.6 
                 240 
                 236 
                 14 
                 22 
                 19 
                 . 
               
               
                   
               
               
                 6 
                 10 
                 61956386 
                 rs772920191 
                 G 
                 GA 
                 ANK3 
                 . 
                 2.45 
                 1.6 
                 240 
                 236 
                 14 
                 22 
                 19 
                 . 
               
               
                   
               
               
                 6 
                 10 
                 62023781 
                 rs144841334 
                 G 
                 A 
                 ANK3 
                 . 
                 2.45 
                 1.6 
                 240 
                 236 
                 14 
                 22 
                 19 
                 0.0268 
               
               
                   
               
               
                 6 
                 10 
                 81901943 
                 rs7080405 
                 G 
                 C 
                 PLAC9 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0188 
               
               
                   
               
               
                 6 
                 10 
                 81926637 
                 rs777020491 
                 G 
                 A 
                 ANXA11 
                 . 
                 2.72 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 10 
                 81926750 
                 rs34332933 
                 G 
                 C 
                 ANXA11 
                 . 
                 2.72 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.0188 
               
               
                   
               
               
                 6 
                 10 
                 94822756 
                 rs58993699 
                 C 
                 T 
                 CYP26C1 
                 . 
                 2.41 
                 1.52 
                 132 
                 116 
                 3 
                 4 
                 4 
                 0.0119 
               
               
                   
               
               
                 6 
                 10 
                 94834060 
                 rs185421897 
                 C 
                 T 
                 CYP26A1 
                 . 
                 1.96 
                 2.11 
                 396 
                 348 
                 7 
                 13 
                 11 
                 0.0139 
               
               
                   
               
               
                 6 
                 10 
                 94835071 
                 rs80188100 
                 A 
                 G 
                 CYP26A1 
                 . 
                 1.96 
                 2.11 
                 396 
                 348 
                 7 
                 13 
                 11 
                 0.0119 
               
               
                   
               
               
                 6 
                 10 
                 94835072 
                 rs75053982 
                 G 
                 A 
                 CYP26A1 
                 . 
                 1.96 
                 2.11 
                 396 
                 348 
                 7 
                 13 
                 11 
                 0.0119 
               
               
                   
               
               
                 6 
                 1 
                 10042683 
                 rs138626416 
                 G 
                 A 
                 NMNAT1 
                 D 
                 1.81 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
                 0.0159 
               
               
                   
               
               
                 6 
                 11 
                 121323228 
                 . 
                 G 
                 A 
                 SORL1 
                 D 
                 7.24 
                 2.28 
                 792 
                 696 
                 2 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 11 
                 121430331 
                 . 
                 T 
                 C 
                 SORL1 
                 D 
                 7.24 
                 2.28 
                 792 
                 696 
                 2 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 11 
                 121440905 
                 rs753319585 
                 G 
                 A 
                 SORL1 
                 D 
                 7.24 
                 2.28 
                 792 
                 696 
                 2 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 11 
                 121457048 
                 rs146197030 
                 T 
                 G 
                 SORL1 
                 . 
                 7.24 
                 2.28 
                 792 
                 696 
                 2 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 11 
                 121460027 
                 rs752525626 
                 G 
                 C 
                 SORL1 
                 D 
                 7.24 
                 2.28 
                 792 
                 696 
                 2 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 11 
                 121489543 
                 rs751110498 
                 A 
                 C 
                 SORL1 
                 D 
                 7.24 
                 2.28 
                 792 
                 696 
                 2 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 116933040 
                 rs28622933 
                 C 
                 G 
                 ATP1A1 
                 . 
                 2.41 
                 2.28 
                 132 
                 116 
                 4 
                 8 
                 8 
                 0.0268 
               
               
                   
               
               
                 6 
                 11 
                 22232870 
                 rs78987921 
                 G 
                 A 
                 ANO5 
                 . 
                 3.62 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.0109 
               
               
                   
               
               
                 6 
                 11 
                 22239801 
                 . 
                 C 
                 T 
                 ANO5 
                 . 
                 3.62 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 145414790 
                 . 
                 G 
                 C 
                 HFE2 
                 . 
                 2.72 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
                 0.0129 
               
               
                   
               
               
                 6 
                 11 
                 487419 
                 . 
                 G 
                 A 
                 PTDSS2 
                 . 
                 3.62 
                 4.55 
                 396 
                 348 
                 1 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 11 
                 489522 
                 rs375041205 
                 C 
                 T 
                 PTDSS2 
                 . 
                 3.62 
                 4.55 
                 396 
                 348 
                 1 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 11 
                 490077 
                 rs374769797 
                 G 
                 A 
                 PTDSS2 
                 . 
                 3.62 
                 4.55 
                 396 
                 348 
                 1 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 15834360 
                 rs2020902 
                 A 
                 G 
                 CASP9 
                 . 
                 1.81 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.0317 
               
               
                   
               
               
                 6 
                 1 
                 15860803 
                 rs11583306 
                 C 
                 T 
                 DNAJC16 
                 . 
                 2.17 
                 3.41 
                 132 
                 116 
                 2 
                 6 
                 6 
                 0.0466 
               
               
                   
               
               
                 6 
                 1 
                 159410340 
                 rs12409540 
                 T 
                 A 
                 OR10J1 
                 . 
                 1.51 
                 5.69 
                 132 
                 116 
                 1 
                 5 
                 5 
                 0.0278 
               
               
                   
               
               
                 6 
                 1 
                 160011511 
                 rs3795339 
                 C 
                 T 
                 KCNJ10 
                 D 
                 2.72 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.0129 
               
               
                   
               
               
                 6 
                 11 
                 613605 
                 . 
                 G 
                 C 
                 IRF7 
                 . 
                 1.58 
                 2.65 
                 526 
                 464 
                 3 
                 7 
                 7 
                 . 
               
               
                   
               
               
                 6 
                 11 
                 615010 
                 rs12290989 
                 G 
                 T 
                 IRF7 
                 . 
                 1.58 
                 2.65 
                 526 
                 464 
                 3 
                 7 
                 7 
                 0.0208 
               
               
                   
               
               
                 6 
                 11 
                 615011 
                 rs12272434 
                 A 
                 T 
                 IRF7 
                 . 
                 1.58 
                 2.65 
                 526 
                 464 
                 3 
                 7 
                 7 
                 0.0208 
               
               
                   
               
               
                 6 
                 11 
                 615087 
                 rs761513714 
                 G 
                 T 
                 IRF7 
                 . 
                 1.58 
                 2.65 
                 526 
                 464 
                 3 
                 7 
                 7 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 16382911 
                 rs72474563 
                 A 
                 G 
                 CLCNKB 
                 . 
                 5.43 
                 1.71 
                 132 
                 116 
                 4 
                 6 
                 6 
                 0.0357 
               
               
                   
               
               
                 6 
                 11 
                 7060977 
                 rs76274604 
                 A 
                 T 
                 NLRP14 
                 . 
                 1.51 
                 2.84 
                 132 
                 116 
                 2 
                 5 
                 5 
                 0.0327 
               
               
                   
               
               
                 6 
                 11 
                 74082748 
                 rs117508615 
                 C 
                 T 
                 PGM2L1 
                 . 
                 1.81 
                 1.71 
                 132 
                 116 
                 4 
                 6 
                 6 
                 0.0387 
               
               
                   
               
               
                 6 
                 1 
                 177247693 
                 rs138799872 
                 C 
                 T 
                 BRINP2 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 2 
                 4 
                 4 
                 0.0119 
               
               
                   
               
               
                 6 
                 1 
                 182821420 
                 rs573535598 
                 AAGG 
                 A 
                 DHX9 
                 . 
                 1.81 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0109 
               
               
                   
               
               
                 6 
                 12 
                 1023218 
                 rs4987207 
                 G 
                 T 
                 RAD52 
                 . 
                 1.81 
                 1.71 
                 396 
                 348 
                 14 
                 21 
                 21 
                 0.0268 
               
               
                   
               
               
                 6 
                 12 
                 1036304 
                 rs2286030 
                 C 
                 T 
                 RAD52 
                 . 
                 1.81 
                 1.71 
                 396 
                 348 
                 14 
                 21 
                 21 
                 0.0347 
               
               
                   
               
               
                 6 
                 12 
                 1038978 
                 rs35278212 
                 C 
                 CT 
                 RAD52 
                 . 
                 1.81 
                 1.71 
                 396 
                 348 
                 14 
                 21 
                 21 
                 0.0635 
               
               
                   
               
               
                 6 
                 12 
                 109719311 
                 rs146550988 
                 C 
                 T 
                 FOXN4 
                 D 
                 1.81 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0109 
               
               
                   
               
               
                 6 
                 12 
                 11001963 
                 . 
                 AT 
                 A 
                 PRR4 
                 . 
                 1.81 
                 2.24 
                 130 
                 116 
                 1 
                 2 
                 2 
                 0.0149 
               
               
                   
               
               
                 6 
                 12 
                 113592306 
                 rs200344876 
                 G 
                 GC 
                 CFAP73 
                 . 
                 2.26 
                 2.84 
                 132 
                 116 
                 2 
                 5 
                 5 
                 0.0169 
               
               
                   
               
               
                 6 
                 12 
                 16377347 
                 rs117974895 
                 C 
                 T 
                 SLC15A5 
                 . 
                 1.51 
                 2.84 
                 132 
                 116 
                 2 
                 5 
                 5 
                 0.0337 
               
               
                   
               
               
                 6 
                 1 
                 227968222 
                 rs12568707 
                 C 
                 T 
                 SNAP47 
                 . 
                 2.26 
                 1.9 
                 132 
                 116 
                 3 
                 5 
                 5 
                 0.0188 
               
               
                   
               
               
                 6 
                 1 
                 22924364 
                 rs72651347 
                 G 
                 A 
                 EPHA8 
                 . 
                 1.81 
                 6.83 
                 264 
                 232 
                 1 
                 6 
                 6 
                 0.0179 
               
               
                   
               
               
                 6 
                 1 
                 22927298 
                 rs569320402 
                 C 
                 T 
                 EPHA8 
                 D 
                 1.81 
                 6.83 
                 264 
                 232 
                 1 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 12 
                 404774 
                 rs140234136 
                 G 
                 T 
                 KDM5A 
                 D 
                 2.53 
                 1.69 
                 420 
                 356 
                 7 
                 10 
                 10 
                 0.0129 
               
               
                   
               
               
                 6 
                 12 
                 417081 
                 rs373321785 
                 G 
                 A 
                 KDM5A 
                 D 
                 2.53 
                 1.69 
                 420 
                 356 
                 7 
                 10 
                 10 
                 . 
               
               
                   
               
               
                 6 
                 12 
                 432376 
                 rs751710770 
                 CAAAA 
                 C 
                 KDM5A 
                 . 
                 2.53 
                 1.69 
                 420 
                 356 
                 7 
                 10 
                 10 
                 . 
               
               
                   
               
               
                 6 
                 12 
                 432376 
                 rs756310068 
                 CAAA 
                 C 
                 KDM5A 
                 . 
                 2.53 
                 1.69 
                 420 
                 356 
                 7 
                 10 
                 10 
                 . 
               
               
                   
               
               
                 6 
                 12 
                 498088 
                 rs117819701 
                 G 
                 A 
                 KDM5A 
                 . 
                 2.53 
                 1.69 
                 420 
                 356 
                 7 
                 10 
                 10 
                 0.0119 
               
               
                   
               
               
                 6 
                 12 
                 51510213 
                 rs77417603 
                 T 
                 A 
                 TFCP2 
                 . 
                 1.58 
                 1.99 
                 132 
                 116 
                 4 
                 7 
                 6 
                 0.0228 
               
               
                   
               
               
                 6 
                 12 
                 63974439 
                 rs61935050 
                 C 
                 T 
                 DPY19L2 
                 . 
                 2.41 
                 2.24 
                 130 
                 116 
                 2 
                 4 
                 4 
                 0.0129 
               
               
                   
               
               
                 6 
                 1 
                 26566248 
                 rs775335757 
                 T 
                 C 
                 CEP85 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 26601570 
                 rs11577318 
                 A 
                 G 
                 CEP85 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 3 
                 0.0228 
               
               
                   
               
               
                 6 
                 1 
                 27943525 
                 rs2231876 
                 G 
                 C 
                 FGR 
                 . 
                 1.63 
                 1.71 
                 132 
                 116 
                 6 
                 9 
                 9 
                 0.0308 
               
               
                   
               
               
                 6 
                 13 
                 26155953 
                 rs7335339 
                 G 
                 C 
                 ATP8A2 
                 . 
                 2.41 
                 4.55 
                 132 
                 116 
                 1 
                 4 
                 3 
                 0.0248 
               
               
                   
               
               
                 6 
                 1 
                 39466786 
                 rs10888613 
                 C 
                 G 
                 AKIRIN1 
                 . 
                 1.63 
                 2.56 
                 132 
                 116 
                 8 
                 18 
                 18 
                 0.1052 
               
               
                   
               
               
                 6 
                 14 
                 39784010 
                 rs539446066 
                 A 
                 ATGTG 
                 CTAGE5 
                 . 
                 1.64 
                 3 
                 128 
                 128 
                 4 
                 12 
                 12 
                 . 
               
               
                   
               
               
                 6 
                 14 
                 39784010 
                 rs539446066 
                 A 
                 ATGTGTG 
                 CTAGE5 
                 . 
                 1.64 
                 3 
                 128 
                 128 
                 4 
                 12 
                 12 
                 0.0615 
               
               
                   
               
               
                 6 
                 14 
                 39784010 
                 rs539446066 
                 A 
                 ATGTGT 
                 CTAGE5 
                 . 
                 1.64 
                 3 
                 128 
                 128 
                 4 
                 12 
                 12 
                 . 
               
               
                   
                   
                   
                   
                   
                 GTG 
               
               
                   
               
               
                 6 
                 14 
                 39784010 
                 rs539446066 
                 A 
                 ATGTGT 
                 CTAGE5 
                 . 
                 1.64 
                 3 
                 128 
                 128 
                 4 
                 12 
                 12 
                 . 
               
               
                   
                   
                   
                   
                   
                 GTGTG 
               
               
                   
                   
                   
                   
                   
                 (SEQ ID 
               
               
                   
                   
                   
                   
                   
                 NO: 4) 
               
               
                   
               
               
                 6 
                 1 
                 47403818 
                 rs79056865 
                 A 
                 G 
                 CYP4A11 
                 . 
                 2.72 
                 1.71 
                 132 
                 116 
                 8 
                 12 
                 12 
                 0.0536 
               
               
                   
               
               
                 6 
                 15 
                 48512900 
                 rs749613571 
                 G 
                 A 
                 SLC12A1 
                 D 
                 10.86 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 15 
                 48580692 
                 rs537641866 
                 G 
                 A 
                 SLC12A1 
                 D 
                 10.86 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 15 
                 48594989 
                 rs755737521 
                 G 
                 T 
                 SLC12A1 
                 D 
                 10.86 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 55076238 
                 rs7535372 
                 C 
                 A 
                 FAM151A 
                 . 
                 1.62 
                 1.53 
                 130 
                 116 
                 19 
                 26 
                 22 
                 0.1687 
               
               
                   
               
               
                 6 
                 15 
                 55484910 
                 rs3759863 
                 G 
                 A 
                 RSL24D1 
                 . 
                 1.81 
                 1.55 
                 132 
                 116 
                 11 
                 15 
                 14 
                 0.0685 
               
               
                   
               
               
                 6 
                 15 
                 75628507 
                 . 
                 C 
                 T 
                 COMMD4 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 15 
                 75631598 
                 rs200129803 
                 C 
                 T 
                 COMMD4 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.0149 
               
               
                   
               
               
                 6 
                 16 
                 1825689 
                 rs3826055 
                 C 
                 T 
                 EME2 
                 . 
                 4.53 
                 5.69 
                 264 
                 232 
                 1 
                 5 
                 5 
                 0.0129 
               
               
                   
               
               
                 6 
                 16 
                 1825789 
                 rs746707908 
                 T 
                 C 
                 EME2 
                 . 
                 4.53 
                 5.69 
                 264 
                 232 
                 1 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 16 
                 2017804 
                 rs146108433 
                 T 
                 G 
                 RNF151 
                 D 
                 3.62 
                 2.28 
                 132 
                 116 
                 4 
                 8 
                 7 
                 0.0387 
               
               
                   
               
               
                 6 
                 16 
                 30455945 
                 rs146596728 
                 A 
                 C 
                 SEPHS2 
                 . 
                 2.72 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.0248 
               
               
                   
               
               
                 6 
                 16 
                 30456188 
                 rs550048089 
                 G 
                 A 
                 SEPHS2 
                 . 
                 2.72 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 16 
                 31004812 
                 rs12445568 
                 T 
                 C 
                 STX1B 
                 . 
                 1.91 
                 1.8 
                 132 
                 116 
                 12 
                 19 
                 17 
                 0.1002 
               
               
                   
               
               
                 6 
                 16 
                 67198846 
                 rs115335849 
                 C 
                 T 
                 HSF4 
                 . 
                 2.41 
                 1.52 
                 132 
                 116 
                 3 
                 4 
                 4 
                 0.0278 
               
               
                   
               
               
                 6 
                 16 
                 733320 
                 . 
                 A 
                 T 
                 JMJD8 
                 . 
                 2.72 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 16 
                 733604 
                 rs79868981 
                 G 
                 A 
                 JMJD8 
                 . 
                 2.72 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.0129 
               
               
                   
               
               
                 6 
                 1 
                 67442275 
                 rs11208979 
                 C 
                 T 
                 MIER1 
                 . 
                 1.66 
                 1.93 
                 132 
                 116 
                 13 
                 22 
                 20 
                 0.1171 
               
               
                   
               
               
                 6 
                 17 
                 16342833 
                 rs11871958 
                 T 
                 C 
                 LRRC75A- 
                 . 
                 1.81 
                 2.11 
                 132 
                 116 
                 7 
                 13 
                 13 
                 0.0823 
               
               
                   
                   
                   
                   
                   
                   
                 AS1 
               
               
                   
               
               
                 6 
                 17 
                 18022218 
                 rs765495851 
                 G 
                 A 
                 MYO15A 
                 D 
                 2.04 
                 1.71 
                 1056 
                 928 
                 4 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 18023739 
                 rs766303371 
                 T 
                 G 
                 MYO15A 
                 D 
                 2.04 
                 1.71 
                 1056 
                 928 
                 4 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 18028490 
                 . 
                 A 
                 G 
                 MYO15A 
                 D 
                 2.04 
                 1.71 
                 1056 
                 928 
                 4 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 18043856 
                 . 
                 A 
                 G 
                 MYO15A 
                 D 
                 2.04 
                 1.71 
                 1056 
                 928 
                 4 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 18051423 
                 . 
                 A 
                 G 
                 MYO15A 
                 D 
                 2.04 
                 1.71 
                 1056 
                 928 
                 4 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 18057215 
                 rs9916193 
                 C 
                 G 
                 MYO15A 
                 . 
                 2.04 
                 1.71 
                 1056 
                 928 
                 4 
                 6 
                 6 
                 0.0119 
               
               
                   
               
               
                 6 
                 17 
                 18064722 
                 rs140029076 
                 C 
                 T 
                 MYO15A 
                 D 
                 2.04 
                 1.71 
                 1056 
                 928 
                 4 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 18071031 
                 rs201763265 
                 C 
                 T 
                 MYO15A 
                 D 
                 2.04 
                 1.71 
                 1056 
                 928 
                 4 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 38511509 
                 rs188616110 
                 C 
                 T 
                 RARA 
                 . 
                 4.53 
                 2.84 
                 132 
                 116 
                 2 
                 5 
                 5 
                 0.0149 
               
               
                   
               
               
                 6 
                 17 
                 47486684 
                 rs2277637 
                 T 
                 C 
                 PHB 
                 . 
                 1.65 
                 1.71 
                 132 
                 116 
                 14 
                 21 
                 17 
                 0.123 
               
               
                   
               
               
                 6 
                 17 
                 67079441 
                 rs143326198 
                 C 
                 G 
                 ABCA6 
                 D 
                 1.63 
                 2.26 
                 656 
                 580 
                 2 
                 4 
                 4 
                 0.0119 
               
               
                   
               
               
                 6 
                 17 
                 67081193 
                 rs527461596 
                 G 
                 C 
                 ABCA6 
                 D 
                 1.63 
                 2.26 
                 656 
                 580 
                 2 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 67109811 
                 rs777203184 
                 T 
                 G 
                 ABCA6 
                 D 
                 1.63 
                 2.26 
                 656 
                 580 
                 2 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 67121068 
                 . 
                 A 
                 G 
                 ABCA6 
                 D 
                 1.63 
                 2.26 
                 656 
                 580 
                 2 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 67124939 
                 . 
                 A 
                 C 
                 ABCA6 
                 D 
                 1.63 
                 2.26 
                 656 
                 580 
                 2 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 78420930 
                 rs151051327 
                 T 
                 C 
                 FUBP1 
                 . 
                 1.52 
                 1.76 
                 396 
                 346 
                 13 
                 20 
                 19 
                 0.0109 
               
               
                   
               
               
                 6 
                 1 
                 78429408 
                 rs2274257 
                 G 
                 C 
                 FUBP1 
                 . 
                 1.52 
                 1.76 
                 396 
                 346 
                 13 
                 20 
                 19 
                 0.0903 
               
               
                   
               
               
                 6 
                 1 
                 78432563 
                 . 
                 A 
                 G 
                 FUBP1 
                 . 
                 1.52 
                 1.76 
                 396 
                 346 
                 13 
                 20 
                 19 
                 . 
               
               
                   
               
               
                 6 
                 18 
                 50432706 
                 rs17389547 
                 A 
                 C 
                 DCC 
                 . 
                 1.81 
                 1.51 
                 396 
                 348 
                 40 
                 53 
                 43 
                 0.0109 
               
               
                   
               
               
                 6 
                 18 
                 50912515 
                 rs3764494 
                 G 
                 A 
                 DCC 
                 . 
                 1.81 
                 1.51 
                 396 
                 348 
                 40 
                 53 
                 43 
                 0.0238 
               
               
                   
               
               
                 6 
                 18 
                 50937026 
                 rs11873515 
                 A 
                 G 
                 DCC 
                 . 
                 1.81 
                 1.51 
                 396 
                 348 
                 40 
                 53 
                 43 
                 0.2252 
               
               
                   
               
               
                 6 
                 19 
                 13318672 
                 . 
                 CCTGCTGC 
                 C 
                 CACNA1A 
                 . 
                 2.45 
                 2.06 
                 708 
                 668 
                 36 
                 70 
                 70 
                 . 
               
               
                   
                   
                   
                   
                 TGCTGCT 
               
               
                   
                   
                   
                   
                 GCTGCTGC 
               
               
                   
                   
                   
                   
                 TGCTG 
               
               
                   
                   
                   
                   
                 (SEQ ID 
               
               
                   
                   
                   
                   
                 NO: 5) 
               
               
                   
               
               
                 6 
                 19 
                 13318672 
                 rs16054 
                 CCTGCTG 
                 C 
                 CACNA1A 
                 . 
                 2.45 
                 2.06 
                 708 
                 668 
                 36 
                 70 
                 70 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 13318672 
                 rs370146696 
                 CCTG 
                 C 
                 CACNA1A 
                 . 
                 2.45 
                 2.06 
                 708 
                 668 
                 36 
                 70 
                 70 
                 0.0714 
               
               
                   
               
               
                 6 
                 19 
                 13318672 
                 rs753460234 
                 C 
                 CCTG 
                 CACNA1A 
                 . 
                 2.45 
                 2.06 
                 708 
                 668 
                 36 
                 70 
                 70 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 13318672 
                 rs753460234 
                 C 
                 CCTGCTG 
                 CACNA1A 
                 . 
                 2.45 
                 2.06 
                 708 
                 668 
                 36 
                 70 
                 70 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 13318672 
                 rs765169827 
                 CCTGCTGC 
                 C 
                 CACNA1A 
                 . 
                 2.45 
                 2.06 
                 708 
                 668 
                 36 
                 70 
                 70 
                 . 
               
               
                   
                   
                   
                   
                 TG 
               
               
                   
                   
                   
                   
                 CTGCTGCTG 
               
               
                   
                   
                   
                   
                 (SEQ ID 
               
               
                   
                   
                   
                   
                 NO: 6) 
               
               
                   
               
               
                 6 
                 19 
                 13394158 
                 . 
                 T 
                 C 
                 CACNA1A 
                 D 
                 2.45 
                 2.06 
                 708 
                 668 
                 36 
                 70 
                 70 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 13410044 
                 . 
                 C 
                 G 
                 CACNA1A 
                 D 
                 2.45 
                 2.06 
                 708 
                 668 
                 36 
                 70 
                 70 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 13616741 
                 . 
                 G 
                 A 
                 CACNA1A 
                 . 
                 2.45 
                 2.06 
                 708 
                 668 
                 36 
                 70 
                 70 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 13616977 
                 rs15999 
                 G 
                 A 
                 CACNA1A 
                 D 
                 2.45 
                 2.06 
                 708 
                 668 
                 36 
                 70 
                 70 
                 0.0159 
               
               
                   
               
               
                 6 
                 19 
                 1367226 
                 rs11668809 
                 G 
                 A 
                 MUM1 
                 . 
                 1.81 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0149 
               
               
                   
               
               
                 6 
                 19 
                 32083223 
                 rs11880125 
                 A 
                 G 
                 THEG5 
                 . 
                 3.02 
                 2.84 
                 264 
                 232 
                 4 
                 10 
                 10 
                 0.0179 
               
               
                   
               
               
                 6 
                 19 
                 32083250 
                 rs79323410 
                 T 
                 C 
                 THEG5 
                 . 
                 3.02 
                 2.84 
                 264 
                 232 
                 4 
                 10 
                 10 
                 0.0179 
               
               
                   
               
               
                 6 
                 19 
                 36394245 
                 rs74258162 
                 T 
                 C 
                 HCST 
                 . 
                 1.81 
                 3.41 
                 132 
                 116 
                 2 
                 6 
                 6 
                 0.0357 
               
               
                   
               
               
                 6 
                 19 
                 38572367 
                 rs562186095 
                 GGCCACC 
                 G 
                 SIPA1L3 
                 . 
                 4.66 
                 2.17 
                 392 
                 348 
                 14 
                 27 
                 27 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 38572367 
                 rs569252662 
                 G 
                 GGCCACC 
                 SIPA1L3 
                 . 
                 4.66 
                 2.17 
                 392 
                 348 
                 14 
                 27 
                 27 
                 0.0337 
               
               
                   
               
               
                 6 
                 19 
                 38590722 
                 . 
                 C 
                 T 
                 SIPA1L3 
                 D 
                 4.66 
                 2.17 
                 392 
                 348 
                 14 
                 27 
                 27 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 39421820 
                 rs2304116 
                 T 
                 G 
                 MRPS12 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0119 
               
               
                   
               
               
                 6 
                 19 
                 39591919 
                 rs182155157 
                 C 
                 G 
                 ACP7 
                 . 
                 1.92 
                 1.93 
                 264 
                 232 
                 10 
                 17 
                 16 
                 0.0387 
               
               
                   
               
               
                 6 
                 19 
                 39592099 
                 rs186807855 
                 T 
                 C 
                 ACP7 
                 . 
                 1.92 
                 1.93 
                 264 
                 232 
                 10 
                 17 
                 16 
                 0.0179 
               
               
                   
               
               
                 6 
                 19 
                 4099225 
                 rs200371894 
                 G 
                 A 
                 MAP2K2 
                 D 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.0119 
               
               
                   
               
               
                 6 
                 19 
                 4099246 
                 . 
                 G 
                 A 
                 MAP2K2 
                 D 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 51582802 
                 rs199715229 
                 C 
                 T 
                 KLK14 
                 D 
                 2.72 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.0119 
               
               
                   
               
               
                 6 
                 19 
                 51585822 
                 rs769468261 
                 G 
                 A 
                 KLK14 
                 . 
                 2.72 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 51729577 
                 rs201473304 
                 ACCCAACA 
                 A 
                 CD33 
                 . 
                 2.11 
                 1.99 
                 132 
                 116 
                 4 
                 7 
                 7 
                 0.0258 
               
               
                   
                   
                   
                   
                 AC 
               
               
                   
                   
                   
                   
                 TGGTATCT 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
                   
                   
                   
                 (SEQ ID 
               
               
                   
                   
                   
                   
                 NO: 7) 
               
               
                   
               
               
                 6 
                 19 
                 53554075 
                 rs1650983 
                 A 
                 G 
                 ERVV-2 
                 . 
                 1.81 
                 4.55 
                 132 
                 116 
                 1 
                 4 
                 4 
                 0.0188 
               
               
                   
               
               
                 6 
                 19 
                 54872594 
                 . 
                 G 
                 A 
                 LAIR1 
                 . 
                 1.81 
                 1.9 
                 396 
                 348 
                 9 
                 15 
                 15 
                 0.0317 
               
               
                   
               
               
                 6 
                 19 
                 54872611 
                 . 
                 A 
                 T 
                 LAIR1 
                 . 
                 1.81 
                 1.9 
                 396 
                 348 
                 9 
                 15 
                 15 
                 0.0308 
               
               
                   
               
               
                 6 
                 19 
                 54872698 
                 . 
                 C 
                 G 
                 LAIR1 
                 . 
                 1.81 
                 1.9 
                 396 
                 348 
                 9 
                 15 
                 15 
                 0.0308 
               
               
                   
               
               
                 6 
                 19 
                 55739813 
                 rs10419308 
                 G 
                 A 
                 TMEM86B 
                 . 
                 1.53 
                 1.79 
                 132 
                 116 
                 7 
                 11 
                 11 
                 0.0704 
               
               
                   
               
               
                 6 
                 19 
                 57956740 
                 rs148699125 
                 C 
                 CA 
                 ZNF749 
                 . 
                 1.81 
                 6.83 
                 132 
                 116 
                 1 
                 6 
                 6 
                 0.0357 
               
               
                   
               
               
                 6 
                 19 
                 58118371 
                 rs78803667 
                 G 
                 A 
                 ZNF530 
                 D 
                 4.53 
                 1.9 
                 132 
                 116 
                 3 
                 5 
                 5 
                 0.0159 
               
               
                   
               
               
                 6 
                 19 
                 6147453 
                 rs16993408 
                 G 
                 C 
                 ACSBG2 
                 . 
                 12.07 
                 1.9 
                 396 
                 348 
                 6 
                 10 
                 9 
                 0.0119 
               
               
                   
               
               
                 6 
                 19 
                 6161219 
                 rs78713134 
                 C 
                 T 
                 ACSBG2 
                 . 
                 12.07 
                 1.9 
                 396 
                 348 
                 6 
                 10 
                 9 
                 0.0238 
               
               
                   
               
               
                 6 
                 19 
                 6183085 
                 . 
                 A 
                 ATAG 
                 ACSBG2 
                 . 
                 12.07 
                 1.9 
                 396 
                 348 
                 6 
                 10 
                 9 
                 . 
               
               
                   
               
               
                 6 
                 20 
                 31040031 
                 rs2236156 
                 C 
                 T 
                 NOL4L 
                 . 
                 5.43 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
                 0.0248 
               
               
                   
               
               
                 6 
                 20 
                 31672812 
                 rs71349705 
                 C 
                 T 
                 BPIFB4 
                 . 
                 2.72 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 20 
                 31677295 
                 rs142982767 
                 C 
                 T 
                 BPIFB4 
                 . 
                 2.72 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.0179 
               
               
                   
               
               
                 6 
                 20 
                 34572606 
                 rs6142471 
                 A 
                 G 
                 CNBD2 
                 D 
                 1.81 
                 4.55 
                 132 
                 116 
                 1 
                 4 
                 3 
                 0.0278 
               
               
                   
               
               
                 6 
                 20 
                 44511257 
                 rs35972756 
                 G 
                 A 
                 ZSWIM1 
                 . 
                 2.72 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.0159 
               
               
                   
               
               
                 6 
                 20 
                 44676727 
                 rs12481488 
                 T 
                 A 
                 SLC12A5 
                 . 
                 1.81 
                 2.28 
                 132 
                 116 
                 2 
                 4 
                 4 
                 0.0238 
               
               
                   
               
               
                 6 
                 21 
                 43412786 
                 rs200509586 
                 GTCA 
                 G 
                 ZBTB21 
                 . 
                 5.43 
                 3.41 
                 132 
                 116 
                 2 
                 6 
                 6 
                 0.0109 
               
               
                   
               
               
                 6 
                 21 
                 44293806 
                 rs146400491 
                 G 
                 A 
                 WDR4 
                 . 
                 3.02 
                 5.69 
                 132 
                 116 
                 1 
                 5 
                 4 
                 0.0208 
               
               
                   
               
               
                 6 
                 21 
                 44488667 
                 . 
                 C 
                 T 
                 CBS 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 21 
                 44492252 
                 rs201827340 
                 G 
                 A 
                 CBS 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 4 
                 0.0129 
               
               
                   
               
               
                 6 
                 2 
                 169791766 
                 . 
                 G 
                 A 
                 ABCB11 
                 D 
                 3.02 
                 2.84 
                 396 
                 348 
                 2 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 169801131 
                 rs118109635 
                 G 
                 A 
                 ABCB11 
                 D 
                 3.02 
                 2.84 
                 396 
                 348 
                 2 
                 5 
                 5 
                 0.0129 
               
               
                   
               
               
                 6 
                 2 
                 169853135 
                 . 
                 A 
                 G 
                 ABCB11 
                 . 
                 3.02 
                 2.84 
                 396 
                 348 
                 2 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 175304621 
                 rs67227536 
                 C 
                 G 
                 GPR155 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 4 
                 0.0139 
               
               
                   
               
               
                 6 
                 2 
                 175333632 
                 rs28588913 
                 G 
                 A 
                 GPR155 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 4 
                 0.0248 
               
               
                   
               
               
                 6 
                 22 
                 25603008 
                 rs13055430 
                 C 
                 T 
                 CRYBB3 
                 . 
                 3.62 
                 3.03 
                 132 
                 116 
                 3 
                 8 
                 8 
                 0.0268 
               
               
                   
               
               
                 6 
                 22 
                 31521167 
                 rs150867939 
                 C 
                 T 
                 INPP5J 
                 D 
                 3.62 
                 2.28 
                 924 
                 812 
                 3 
                 6 
                 6 
                 0.0129 
               
               
                   
               
               
                 6 
                 22 
                 31521324 
                 . 
                 C 
                 A 
                 INPP5J 
                 D 
                 3.62 
                 2.28 
                 924 
                 812 
                 3 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 22 
                 31521552 
                 rs774897780 
                 G 
                 A 
                 INPP5J 
                 D 
                 3.62 
                 2.28 
                 924 
                 812 
                 3 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 22 
                 31522468 
                 rs767028605 
                 G 
                 A 
                 INPP5J 
                 D 
                 3.62 
                 2.28 
                 924 
                 812 
                 3 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 22 
                 31524007 
                 rs769593351 
                 A 
                 G 
                 INPP5J 
                 D 
                 3.62 
                 2.28 
                 924 
                 812 
                 3 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 22 
                 31524578 
                 rs202068549 
                 C 
                 T 
                 INPP5J 
                 D 
                 3.62 
                 2.28 
                 924 
                 812 
                 3 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 22 
                 31530095 
                 . 
                 G 
                 C 
                 INPP5J 
                 D 
                 3.62 
                 2.28 
                 924 
                 812 
                 3 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 232458085 
                 rs145183277 
                 TGAGA 
                 T 
                 C2orf57 
                 . 
                 2.09 
                 2.84 
                 132 
                 116 
                 6 
                 15 
                 15 
                 0.0536 
               
               
                   
               
               
                 6 
                 22 
                 32992729 
                 rs191241866 
                 G 
                 A 
                 SYN3 
                 . 
                 5.43 
                 . 
                 132 
                 116 
                 0 
                 3 
                 3 
                 0.0129 
               
               
                   
               
               
                 6 
                 2 
                 237246998 
                 . 
                 G 
                 T 
                 IQCA1 
                 D 
                 2.72 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 237247013 
                 rs186626813 
                 G 
                 A 
                 IQCA1 
                 D 
                 2.72 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.0129 
               
               
                   
               
               
                 6 
                 2 
                 239344663 
                 rs11904390 
                 T 
                 A 
                 ASB1 
                 . 
                 1.97 
                 3.41 
                 132 
                 116 
                 4 
                 12 
                 12 
                 0.0595 
               
               
                   
               
               
                 6 
                 22 
                 40801855 
                 rs188579679 
                 C 
                 T 
                 SGSM3 
                 . 
                 2.72 
                 . 
                 132 
                 116 
                 0 
                 6 
                 6 
                 0.0169 
               
               
                   
               
               
                 6 
                 22 
                 43933284 
                 rs3833393 
                 CCT 
                 C 
                 EFCAB6 
                 . 
                 1.63 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 4 
                 0.0159 
               
               
                   
               
               
                 6 
                 22 
                 44131813 
                 . 
                 C 
                 T 
                 EFCAB6 
                 D 
                 1.63 
                 2.28 
                 264 
                 232 
                 2 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 22 
                 46668317 
                 rs779119363 
                 A 
                 G 
                 TTC38 
                 . 
                 3.62 
                 1.71 
                 396 
                 348 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 22 
                 46679924 
                 rs201314224 
                 G 
                 C 
                 TTC38 
                 D 
                 3.62 
                 1.71 
                 396 
                 348 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 22 
                 46684341 
                 rs763990471 
                 G 
                 A 
                 TTC38 
                 . 
                 3.62 
                 1.71 
                 396 
                 348 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 22 
                 50754445 
                 rs80243206 
                 A 
                 T 
                 DENND6B 
                 . 
                 1.51 
                 2.84 
                 264 
                 232 
                 2 
                 5 
                 5 
                 0.0198 
               
               
                   
               
               
                 6 
                 22 
                 50756452 
                 rs73439320 
                 A 
                 G 
                 DENND6B 
                 . 
                 1.51 
                 2.84 
                 264 
                 232 
                 2 
                 5 
                 5 
                 0.0208 
               
               
                   
               
               
                 6 
                 2 
                 27729343 
                 . 
                 C 
                 A 
                 GCKR 
                 . 
                 5.43 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 27729453 
                 . 
                 G 
                 A 
                 GCKR 
                 . 
                 5.43 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 28634790 
                 rs12624279 
                 G 
                 A 
                 FOSL2 
                 . 
                 1.65 
                 1.63 
                 132 
                 116 
                 21 
                 30 
                 25 
                 0.1835 
               
               
                   
               
               
                 6 
                 2 
                 31412347 
                 rs78099670 
                 G 
                 A 
                 CAPN14 
                 . 
                 5.07 
                 1.59 
                 660 
                 580 
                 5 
                 7 
                 7 
                 0.0179 
               
               
                   
               
               
                 6 
                 2 
                 31414833 
                 . 
                 G 
                 T 
                 CAPN14 
                 D 
                 5.07 
                 1.59 
                 660 
                 580 
                 5 
                 7 
                 7 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 31414844 
                 rs147299374 
                 C 
                 T 
                 CAPN14 
                 D 
                 5.07 
                 1.59 
                 660 
                 580 
                 5 
                 7 
                 7 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 31414959 
                 rs141014145 
                 A 
                 G 
                 CAPN14 
                 D 
                 5.07 
                 1.59 
                 660 
                 580 
                 5 
                 7 
                 7 
                 0.0149 
               
               
                   
               
               
                 6 
                 2 
                 31422395 
                 rs200657395 
                 TCTC 
                 T 
                 CAPN14 
                 . 
                 5.07 
                 1.59 
                 660 
                 580 
                 5 
                 7 
                 7 
                 0.0139 
               
               
                   
               
               
                 6 
                 2 
                 47399601 
                 rs4953472 
                 A 
                 G 
                 CALM2 
                 . 
                 3.62 
                 1.71 
                 132 
                 116 
                 4 
                 6 
                 6 
                 0.0327 
               
               
                   
               
               
                 6 
                 3 
                 107097080 
                 rs138204694 
                 CAAATG 
                 C 
                 CCDC54 
                 . 
                 1.81 
                 7.97 
                 132 
                 116 
                 1 
                 7 
                 7 
                 0.0317 
               
               
                   
               
               
                 6 
                 3 
                 111828384 
                 rs397949663 
                 G 
                 GT 
                 C3orf52 
                 . 
                 1.56 
                 1.54 
                 132 
                 116 
                 28 
                 38 
                 33 
                 0.2569 
               
               
                   
               
               
                 6 
                 3 
                 119242443 
                 rs58978800 
                 C 
                 T 
                 TIMMDC1 
                 . 
                 1.81 
                 4.55 
                 132 
                 116 
                 1 
                 4 
                 4 
                 0.0258 
               
               
                   
               
               
                 6 
                 3 
                 122459290 
                 rs16338 
                 G 
                 GAGA 
                 HSPBAP1 
                 . 
                 1.93 
                 1.52 
                 264 
                 232 
                 24 
                 32 
                 30 
                 0.126 
               
               
                   
               
               
                 6 
                 3 
                 122459732 
                 rs35887395 
                 G 
                 A 
                 HSPBAP1 
                 . 
                 1.93 
                 1.52 
                 264 
                 232 
                 24 
                 32 
                 30 
                 0.126 
               
               
                   
               
               
                 6 
                 3 
                 169546730 
                 rs149140811 
                 C 
                 T 
                 LRRIQ4 
                 . 
                 2.11 
                 1.99 
                 132 
                 116 
                 4 
                 7 
                 6 
                 0.0357 
               
               
                   
               
               
                 6 
                 3 
                 183908937 
                 rs765039315 
                 C 
                 T 
                 ABCF3 
                 D 
                 5.43 
                 1.71 
                 396 
                 348 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 3 
                 183910604 
                 rs118183801 
                 T 
                 C 
                 ABCF3 
                 D 
                 5.43 
                 1.71 
                 396 
                 348 
                 2 
                 3 
                 3 
                 0.0169 
               
               
                   
               
               
                 6 
                 3 
                 183911455 
                 . 
                 A 
                 G 
                 ABCF3 
                 D 
                 5.43 
                 1.71 
                 396 
                 348 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 3 
                 187451313 
                 rs140944763 
                 T 
                 A 
                 BCL6 
                 . 
                 1.55 
                 6.83 
                 132 
                 116 
                 1 
                 6 
                 6 
                 0.0228 
               
               
                   
               
               
                 6 
                 3 
                 32030579 
                 rs373566244 
                 GT 
                 G 
                 ZNF860 
                 . 
                 2.72 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.0129 
               
               
                   
               
               
                 6 
                 3 
                 50219709 
                 rs12639175 
                 A 
                 G 
                 SEMA3F 
                 . 
                 1.81 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0129 
               
               
                   
               
               
                 6 
                 4 
                 121719584 
                 rs35363618 
                 T 
                 TA 
                 PRDM5 
                 . 
                 1.77 
                 1.99 
                 132 
                 116 
                 24 
                 42 
                 34 
                 0.1885 
               
               
                   
               
               
                 6 
                 4 
                 16181283 
                 rs78942971 
                 A 
                 G 
                 TAPT1 
                 . 
                 2.9 
                 2.25 
                 98 
                 116 
                 3 
                 8 
                 8 
                 0.0248 
               
               
                   
               
               
                 6 
                 4 
                 177109395 
                 rs200650536 
                 T 
                 G 
                 SPATA4 
                 . 
                 2.72 
                 3.39 
                 262 
                 232 
                 1 
                 3 
                 3 
                 0.0149 
               
               
                   
               
               
                 6 
                 4 
                 177116495 
                 . 
                 C 
                 A 
                 SPATA4 
                 . 
                 2.72 
                 3.39 
                 262 
                 232 
                 1 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 4 
                 2233893 
                 rs117602484 
                 A 
                 G 
                 HAUS3 
                 . 
                 3.32 
                 1.66 
                 210 
                 190 
                 2 
                 3 
                 3 
                 0.0119 
               
               
                   
               
               
                 6 
                 4 
                 2240347 
                 rs376063631 
                 C 
                 T 
                 HAUS3 
                 D 
                 3.32 
                 1.66 
                 210 
                 190 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 4 
                 69094459 
                 rs75647314 
                 C 
                 A 
                 TMPRSS11B 
                 . 
                 2.11 
                 1.59 
                 264 
                 232 
                 5 
                 7 
                 7 
                 0.0278 
               
               
                   
               
               
                 6 
                 4 
                 69096987 
                 rs575638339 
                 C 
                 T 
                 TMPRSS11B 
                 D 
                 2.11 
                 1.59 
                 264 
                 232 
                 5 
                 7 
                 7 
                 . 
               
               
                   
               
               
                 6 
                 4 
                 71888240 
                 rs67437265 
                 C 
                 T 
                 DCK 
                 D 
                 1.81 
                 1.82 
                 132 
                 116 
                 5 
                 8 
                 8 
                 0.0387 
               
               
                   
               
               
                 6 
                 4 
                 76447062 
                 rs76333976 
                 G 
                 C 
                 THAP6 
                 D 
                 1.81 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0129 
               
               
                   
               
               
                 6 
                 4 
                 76581064 
                 rs6823013 
                 C 
                 T 
                 G3BP2 
                 . 
                 1.81 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.0198 
               
               
                   
               
               
                 6 
                 5 
                 140182074 
                 rs17844259 
                 G 
                 A 
                 PCDHA3 
                 D 
                 3.62 
                 2.28 
                 132 
                 116 
                 2 
                 4 
                 4 
                 0.0179 
               
               
                   
               
               
                 6 
                 5 
                 26886200 
                 rs41271091 
                 C 
                 A 
                 CDH9 
                 . 
                 1.84 
                 1.87 
                 128 
                 114 
                 12 
                 20 
                 20 
                 0.0972 
               
               
                   
               
               
                 6 
                 5 
                 70898466 
                 . 
                 T 
                 TC 
                 MCCC2 
                 . 
                 1.81 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 0.0179 
               
               
                   
               
               
                 6 
                 5 
                 70922542 
                 rs549784997 
                 C 
                 T 
                 MCCC2 
                 D 
                 1.81 
                 1.71 
                 264 
                 232 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 6 
                 109721228 
                 rs4946972 
                 A 
                 C 
                 PPIL6 
                 . 
                 1.93 
                 1.82 
                 132 
                 116 
                 10 
                 16 
                 15 
                 0.1032 
               
               
                   
               
               
                 6 
                 6 
                 109763947 
                 rs35444917 
                 TC 
                 T 
                 SMPD2 
                 . 
                 1.81 
                 1.82 
                 132 
                 116 
                 10 
                 16 
                 15 
                 0.1032 
               
               
                   
               
               
                 6 
                 6 
                 116783619 
                 rs117361304 
                 T 
                 G 
                 FAM26F 
                 . 
                 2.63 
                 3.03 
                 132 
                 116 
                 6 
                 16 
                 16 
                 0.0635 
               
               
                   
               
               
                 6 
                 6 
                 136554647 
                 rs2274141 
                 A 
                 T 
                 MTFR2 
                 . 
                 2.02 
                 2.15 
                 112 
                 104 
                 1 
                 2 
                 2 
                 0.0407 
               
               
                   
               
               
                 6 
                 6 
                 167738715 
                 rs12526096 
                 G 
                 A 
                 TTLL2 
                 . 
                 3.62 
                 3.03 
                 132 
                 116 
                 3 
                 8 
                 8 
                 0.0347 
               
               
                   
               
               
                 6 
                 6 
                 25691362 
                 rs17492659 
                 C 
                 T 
                 SCGN 
                 . 
                 1.81 
                 1.99 
                 132 
                 116 
                 4 
                 7 
                 7 
                 0.0417 
               
               
                   
               
               
                 6 
                 6 
                 26507069 
                 rs188130447 
                 T 
                 C 
                 BTN1A1 
                 . 
                 1.81 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.0208 
               
               
                   
               
               
                 6 
                 6 
                 26509379 
                 rs752379950 
                 C 
                 T 
                 BTN1A1 
                 . 
                 1.81 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 6 
                 32361841 
                 . 
                 T 
                 C 
                 BTNL2 
                 . 
                 1.85 
                 1.67 
                 660 
                 580 
                 53 
                 78 
                 74 
                 0.0417 
               
               
                   
               
               
                 6 
                 6 
                 32361842 
                 . 
                 G 
                 A 
                 BTNL2 
                 . 
                 1.85 
                 1.67 
                 660 
                 580 
                 53 
                 78 
                 74 
                 0.0417 
               
               
                   
               
               
                 6 
                 6 
                 32369554 
                 . 
                 G 
                 A 
                 BTNL2 
                 . 
                 1.85 
                 1.67 
                 660 
                 580 
                 53 
                 78 
                 74 
                 0.1171 
               
               
                   
               
               
                 6 
                 6 
                 32369586 
                 . 
                 GAA 
                 G 
                 BTNL2 
                 . 
                 1.85 
                 1.67 
                 660 
                 580 
                 53 
                 78 
                 74 
                 . 
               
               
                   
               
               
                 6 
                 6 
                 32370969 
                 . 
                 TG 
                 T 
                 BTNL2 
                 . 
                 1.85 
                 1.67 
                 660 
                 580 
                 53 
                 78 
                 74 
                 0.1984 
               
               
                   
               
               
                 6 
                 6 
                 36929653 
                 rs144897670 
                 C 
                 T 
                 PI16 
                 . 
                 1.81 
                 3.41 
                 132 
                 116 
                 1 
                 3 
                 3 
                 0.0129 
               
               
                   
               
               
                 6 
                 6 
                 39330207 
                 rs9349115 
                 C 
                 G 
                 KIF6 
                 . 
                 1.81 
                 . 
                 132 
                 116 
                 0 
                 7 
                 7 
                 0.0367 
               
               
                   
               
               
                 6 
                 6 
                 87994504 
                 rs35259282 
                 C 
                 T 
                 GJB7 
                 D 
                 1.81 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 0.0188 
               
               
                   
               
               
                 6 
                 6 
                 87994537 
                 rs112552839 
                 G 
                 A 
                 GJB7 
                 D 
                 1.81 
                 4.55 
                 264 
                 232 
                 1 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 7 
                 123267310 
                 rs116956332 
                 C 
                 T 
                 ASB15 
                 . 
                 3.62 
                 2.28 
                 132 
                 116 
                 1 
                 2 
                 2 
                 0.0208 
               
               
                   
               
               
                 6 
                 7 
                 12727793 
                 rs117537847 
                 G 
                 A 
                 ARL4A 
                 . 
                 1.61 
                 2.03 
                 132 
                 114 
                 4 
                 7 
                 7 
                 0.0466 
               
               
                   
               
               
                 6 
                 7 
                 40277228 
                 rs76667176 
                 T 
                 C 
                 SUGCT 
                 . 
                 1.51 
                 . 
                 396 
                 348 
                 0 
                 5 
                 5 
                 0.0119 
               
               
                   
               
               
                 6 
                 7 
                 40899963 
                 rs751805172 
                 C 
                 G 
                 SUGCT 
                 D 
                 1.51 
                 . 
                 396 
                 348 
                 0 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 7 
                 40899965 
                 rs767692645 
                 C 
                 G 
                 SUGCT 
                 D 
                 1.51 
                 . 
                 396 
                 348 
                 0 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 7 
                 72984917 
                 . 
                 CGTT 
                 C 
                 TBL2 
                 . 
                 1.81 
                 2.84 
                 132 
                 116 
                 2 
                 5 
                 5 
                 0.0159 
               
               
                   
               
               
                 6 
                 7 
                 73083744 
                 . 
                 C 
                 T 
                 VPS37D 
                 . 
                 5.43 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.0129 
               
               
                   
               
               
                 6 
                 7 
                 73630406 
                 . 
                 G 
                 A 
                 LAT2 
                 . 
                 1.97 
                 2.28 
                 132 
                 116 
                 6 
                 12 
                 11 
                 0.0446 
               
               
                   
               
               
                 6 
                 7 
                 7476098 
                 rs11984435 
                 T 
                 C 
                 COL28A1 
                 . 
                 2.41 
                 2.28 
                 396 
                 348 
                 4 
                 8 
                 8 
                 0.0208 
               
               
                   
               
               
                 6 
                 7 
                 7491996 
                 rs148703211 
                 G 
                 C 
                 COL28A1 
                 D 
                 2.41 
                 2.28 
                 396 
                 348 
                 4 
                 8 
                 8 
                 0.0109 
               
               
                   
               
               
                 6 
                 7 
                 7559695 
                 . 
                 G 
                 C 
                 COL28A1 
                 D 
                 2.41 
                 2.28 
                 396 
                 348 
                 4 
                 8 
                 8 
                 . 
               
               
                   
               
               
                 6 
                 8 
                 10677699 
                 rs61757720 
                 A 
                 T 
                 PINX1 
                 . 
                 2.74 
                 1.72 
                 264 
                 230 
                 2 
                 3 
                 3 
                 0.0139 
               
               
                   
               
               
                 6 
                 8 
                 10692283 
                 rs746583094 
                 G 
                 A 
                 PINX1 
                 D 
                 2.74 
                 1.72 
                 264 
                 230 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 8 
                 116599274 
                 rs745384526 
                 G 
                 A 
                 TRPS1 
                 D 
                 5.43 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 8 
                 116599415 
                 . 
                 T 
                 C 
                 TRPS1 
                 D 
                 5.43 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 8 
                 30697414 
                 rs149889016 
                 A 
                 G 
                 TEX15 
                 . 
                 3.62 
                 2.24 
                 130 
                 116 
                 1 
                 2 
                 2 
                 0.0188 
               
               
                   
               
               
                 6 
                 9 
                 137998709 
                 rs35408956 
                 T 
                 A 
                 OLFM1 
                 . 
                 2.07 
                 2.28 
                 132 
                 116 
                 4 
                 8 
                 8 
                 0.0367 
               
               
                   
               
               
                 6 
                 9 
                 140248783 
                 rs372878424 
                 G 
                 A 
                 EXD3 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 9 
                 140249147 
                 rs143654067 
                 C 
                 T 
                 EXD3 
                 . 
                 1.81 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.0119 
               
               
                   
               
               
                 6 
                 9 
                 5892552 
                 rs148372841 
                 G 
                 C 
                 MLANA 
                 . 
                 4.53 
                 5.69 
                 132 
                 116 
                 1 
                 5 
                 5 
                 0.0139 
               
               
                   
               
               
                 6 
                 X 
                 2871176 
                 rs56393981 
                 G 
                 A 
                 ARSE 
                 . 
                 2.74 
                 3.41 
                 132 
                 116 
                 2 
                 6 
                 5 
                 0.0262 
               
               
                   
               
               
                 6 
                 X 
                 49114808 
                 . 
                 C 
                 A 
                 FOXP3 
                 D 
                 2.06 
                 5.12 
                 132 
                 116 
                 2 
                 9 
                 8 
                 0.0393 
               
               
                   
               
               
                 6 
                 X 
                 8763309 
                 . 
                 GCTGCTGC 
                 * 
                 FAM9A 
                 . 
                 3.69 
                 . 
                 130 
                 114 
                 0 
                 4 
                 4 
                 . 
               
               
                   
                   
                   
                   
                 TG 
               
               
                   
                   
                   
                   
                 CTGCGGCTT 
               
               
                   
                   
                   
                   
                 (SEQ ID 
               
               
                   
                   
                   
                   
                 NO: 8) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 High priority candidate gene list in Rheumatoid Arthritis disease. 
               
            
           
           
               
               
               
               
               
            
               
                 Gene 
                 SNP 
                 p-Value 
                 Odd ratio 
                 References 
               
               
                   
               
               
                 ABHD6 
                 rs73081554 
                 5.00E−08 
                 1.18 
                 Okada Y, PMID: 24390342 
               
               
                 ACOXL 
                 rs6732565 
                 3.00E−08 
                 1.07 
                 Okada Y, PMID: 24390342 
               
               
                 AFF3 
                 rs9653442| 
                  1.00E−14| 
                 1.12|1.12| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs11676922| 
                  1.00E−14| 
                 1.12 
                 E A, PMID: 20453842|Jiang 
               
               
                   
                 rs10865035 
                  2.00E−08| 
                   
                 L, PMID: 24782177|Stahl 
               
               
                   
                   
                 2.00E−06 
                   
                 E A, PMID: 20453842 
               
               
                 AHNAK2 
                 rs2582532 
                 3.00E−07 
                 1.17 
                 Okada Y, PMID: 24390342 
               
               
                 AIRE 
                 rs2075876| 
                  4.00E−09| 
                 1.18|1.16 
                 Terao C, PMID: 21505073|Terao 
               
               
                   
                 rs760426 
                 4.40E−08 
                   
                 C, PMID: 21505073 
               
               
                 ANAPC4 
                 rs3816587 
                 9.00E−06 
                 1.09 
                 WTCCC, PMID: 17554300 
               
               
                 ANKRD55 
                 rs77331626| 
                  7.00E−24| 
                 1.21|1.21| 
                 Okada Y, PMID: 
               
               
                   
                 rs7731626| 
                  8.00E−23| 
                 1.28 
                 24390342|Okada Y, PMID: 
               
               
                   
                 rs6859219 
                 1.00E−11 
                   
                 24390342|Stahl E A, PMID: 
               
               
                   
                   
                   
                   
                 20453842 
               
               
                 ANXA3 
                 rs2867461 
                 1.00E−12 
                 1.13 
                 Okada Y, PMID: 22446963 
               
               
                 APOM 
                 rs805297 
                 3.00E−10 
                 1.56 
                 Hu H J, PMID: 21844665 
               
               
                 ARAP1 
                 rs3781913 
                 6.00E−10 
                 1.12 
                 Okada Y, PMID: 22446963 
               
               
                 ARHGEF3 
                 rs2062583 
                 2.16E−06 
                 0.63 
                 Freudenberg J, PMID: 21452313 
               
               
                 ARID5B 
                 rs71508903| 
                  1.00E−08| 
                 1.18|1.18| 
                 Okada Y, PMID: 
               
               
                   
                 rs71508903| 
                  1.00E−08| 
                 1.16 
                 24390342|Okada Y, PMID: 
               
               
                   
                 rs10821944 
                 6.00E−18 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 ARL15 
                 rs255758 
                 7.00E−06 
                 1.42 
                 Negi S, PMID: 23918589 
               
               
                 ATG5 
                 rs9372120 
                 4.00E−08 
                 1.10 
                 Okada Y, PMID: 24390342 
               
               
                 ATM 
                 chr11: 107967350 
                 1.00E−08 
                 1.21 
                 Okada Y, PMID: 24390342 
               
               
                 B3GNT2 
                 rs13385025| 
                  9.00E−07| 
                 1.11|1.11 
                 Okada Y, PMID: 
               
               
                   
                 rs11900673 
                 1.00E−08 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 BATF 
                 rs7155603 
                 1.00E−07 
                 1.16 
                 Stahl E A, PMID: 20453842 
               
               
                 BLK 
                 rs2736337| 
                  2.00E−07| 
                 1.15|0.77| 
                 Okada Y, PMID: 
               
               
                   
                 rs1600249| 
                  5.00E−06| 
                 1.29|1.19 
                 24390342|Freudenberg J, PMID: 
               
               
                   
                 rs2736340 
                  1.22E−05| 
                   
                 21452313|Freudenberg J, PMID: 
               
               
                   
                   
                 6.00E−09 
                   
                 21452313|Gregersen P K, PMID: 
               
               
                   
                   
                   
                   
                 19503088 
               
               
                 BTNL2 
                 rs3763309 
                  2.00E−124 
                 2.30 
                 Orozco G, PMID: 24449572 
               
               
                 C1QBP 
                 rs72634030 
                 2.00E−09 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 C4orf52 
                 rs11933540 
                 1.00E−16 
                 1.15 
                 Okada Y, PMID: 24390342 
               
               
                 C5 
                 rs10985070| 
                  4.00E−09| 
                 1.09|1.13| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs3761847| 
                  2.00E−07| 
                 NR 
                 E A, PMID: 20453842|Gregersen 
               
               
                   
                 rs881375 
                 4.00E−08 
                   
                 P K, PMID: 19503088 
               
               
                 C5orf30 
                 rs2561477| 
                  1.00E−10| 
                 1.09|1.14 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs26232 
                 4.00E−08 
                   
                 E A, PMID: 20453842 
               
               
                 C6orf10 
                 rs9275406 
                 3.00E−12 
                 2.10 
                 Negi S, PMID: 23918589 
               
               
                 CASP8 
                 rs6715284 
                 2.00E−09 
                 1.15 
                 Okada Y, PMID: 24390342 
               
               
                 CCL19 
                 rs11574914 
                 2.00E−15 
                 1.13 
                 Okada Y, PMID: 24390342 
               
               
                 CCL21 
                 rs951005| 
                  4.00E−10| 
                 1.19|1.12| 
                 Stahl E A, PMID: 
               
               
                   
                 rs2812378| 
                  3.00E−08| 
                 1.13 
                 20453842|Raychaudhuri 
               
               
                   
                 rs11574914 
                 2.00E−15 
                   
                 S, PMID: 18794853|Okada 
               
               
                   
                   
                   
                   
                 Y, PMID: 24390342 
               
               
                 CCR6 
                 rs1571878| 
                  1.00E−22| 
                 1.28|1.13| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs3093023| 
                  2.00E−11| 
                 NR|NR 
                 E A, PMID: 20453842|Jiang 
               
               
                   
                 rs1854853| 
                  4.00E−09| 
                   
                 L, PMID: 24782177|Jiang 
               
               
                   
                 rs3093024 
                  2.00E−10| 
                   
                 L, PMID: 24782177|Kochi 
               
               
                   
                   
                 8.00E−19 
                   
                 Y, PMID: 20453841 
               
               
                 CD2 
                 rs624988 
                 8.00E−10 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 CD226 
                 rs2469434 
                 1.00E−08 
                 NR 
                 Okada Y, PMID: 24390342 
               
               
                 CD244 
                 rs11265493| 
                  4.10E−07| 
                 1.28|1.3| 
                 Suzuki A, PMID: 
               
               
                   
                 rs3753389| 
                  8.00E−08| 
                 1.31|1.28| 
                 18794858|Suzuki A, PMID: 
               
               
                   
                 rs3766379| 
                  3.00E−08| 
                 1.31 
                 18794858|Suzuki A, PMID: 
               
               
                   
                 rs1319651| 
                  6.40E−07| 
                   
                 18794858|Suzuki A, PMID: 
               
               
                   
                 rs6682654 
                 7.00E−08 
                   
                 18794858|Suzuki A, PMID: 
               
               
                   
                   
                   
                   
                 18794858 
               
               
                 CD247 
                 rs840016 
                 2.00E−06 
                 1.11 
                 Stahl E A, PMID: 20453842 
               
               
                 CD28 
                 rs1980422 
                 2.00E−13 
                 1.13 
                 Okada Y, PMID: 24390342 
               
               
                 CD40 
                 rs4239702| 
                  1.00E−16| 
                 1.14|0.85| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs4810485 
                  3.00E−09| 
                 1.15 
                 E A, PMID: 
               
               
                   
                   
                 8.00E−09 
                   
                 20453842|Raychaudhuri 
               
               
                   
                   
                   
                   
                 S, PMID: 18794853 
               
               
                 CD5 
                 rs508970 
                 3.00E−06 
                 1.07 
                 Okada Y, PMID: 24390342 
               
               
                 CD83 
                 chr6: 14103212| 
                  3.00E−06| 
                 1.16|1.14 
                 Okada Y, PMID: 
               
               
                   
                 rs12529514 
                 2.00E−08 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 CDK2 
                 rs773125 
                 1.00E−10 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 CDK4 
                 rs1633360 
                 1.00E−07 
                 1.07 
                 Okada Y, PMID: 24390342 
               
               
                 CDK5RAP2 
                 rs12379034 
                 1.00E−12 
                 1.34 
                 Jiang L, PMID: 24782177 
               
               
                 CDK6 
                 rs4272|rs42041 
                  1.00E−08| 
                 1.10|1.11 
                 Okada Y, PMID: 
               
               
                   
                   
                 4.00E−06 
                   
                 24390342|Raychaudhuri 
               
               
                   
                   
                   
                   
                 S, PMID: 18794853 
               
               
                 CEP57 
                 rs4409785 
                 1.00E−11 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 CFLAR 
                 rs6715284 
                 2.00E−09 
                 1.15 
                 Okada Y, PMID: 24390342 
               
               
                 CLNK 
                 rs13142500 
                 2.00E−06 
                 1.10 
                 Okada Y, PMID: 24390342 
               
               
                 CLYBL 
                 rs9557321 
                 6.00E−08 
                 1.73 
                 Bossini-Castillo L, PMID: 
               
               
                   
                   
                   
                   
                 24532677 
               
               
                 COG6 
                 rs9603616 
                 2.00E−12 
                 1.10 
                 Okada Y, PMID: 24390342 
               
               
                 CSF2 
                 rs657075| 
                  6.00E−06| 
                 1.12|1.12 
                 Okada Y, PMID: 
               
               
                   
                 rs657075 
                 3.00E−10 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 CSF3 
                 chr17: 38031857 
                 2.00E−12 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 CTLA4 
                 rs3087243| 
                  3.00E−25| 
                 1.14|1.15| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs3087243| 
                  1.00E−08| 
                 1.09|NR 
                 E A, PMID: 20453842|Doroth??e 
               
               
                   
                 rs231775| 
                  6.30E−07| 
                   
                 Diogo, PMID: 23261300|Gregersen 
               
               
                   
                 rs231735 
                 6.00E−09 
                   
                 P K, PMID: 19503088 
               
               
                 CXCR5 
                 rs10790268 
                 1.00E−15 
                 1.14 
                 Okada Y, PMID: 24390342 
               
               
                 DNASE1L3 
                 rs73081554 
                 5.00E−08 
                 1.18 
                 Okada Y, PMID: 24390342 
               
               
                 DPP4 
                 rs12617656 
                 1.00E−08 
                 1.24 
                 Jiang L, PMID: 24782177 
               
               
                 EOMES 
                 rs3806624 
                 3.00E−08 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 ETS1 
                 rs73013527| 
                  1.00E−06| 
                 1.08|1.09 
                 Okada Y, PMID: 
               
               
                   
                 rs4937362 
                 8.00E−07 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 ETV7 
                 rs2234067 
                 1.60E−09 
                 1.15 
                 Okada Y, PMID: 24390342 
               
               
                 FADS1 
                 rs968567 
                 2.00E−08 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 FADS2 
                 rs968567 
                 2.00E−08 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 FADS3 
                 rs968567 
                 2.00E−08 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 FAM124A 
                 rs3790022 
                 1.00E−06 
                 1.49 
                 Bossini-Castillo L, PMID: 
               
               
                   
                   
                   
                   
                 24532677 
               
               
                 FCGR2A 
                 rs72717009| 
                  1.00E−07| 
                 1.13|1.10| 
                 Okada Y, PMID: 
               
               
                   
                 rs1801274| 
                  2.40E−07| 
                 1.14 
                 24390342|Doroth??e 
               
               
                   
                 rs11810143 
                 1.80E−07 
                   
                 Diogo, PMID: 
               
               
                   
                   
                   
                   
                 23261300|Doroth??e 
               
               
                   
                   
                   
                   
                 Diogo, PMID: 23261300 
               
               
                 FCRL3 
                 rs2317230 
                 2.00E−07 
                 1.07 
                 Okada Y, PMID: 24390342 
               
               
                 FLI1 
                 rs4937362 
                 8.00E−07 
                 1.09 
                 Okada Y, PMID: 22446963 
               
               
                 GATA3 
                 rs3824660 
                 2.00E−08 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 GATSL3 
                 rs1043099 
                 7.00E−09 
                 1.19 
                 Orozco G, PMID: 24449572 
               
               
                 GCH1 
                 rs3783637 
                 2.00E−06 
                 1.10 
                 Okada Y, PMID: 22446963 
               
               
                 GMCL1L 
                 rs2961663 
                 4.00E−06 
                 NR 
                 Padyukov L, PMID: 21156761 
               
               
                 GPR125 
                 rs6448119 
                 7.00E−06 
                 NR 
                 Padyukov L, PMID: 21156761 
               
               
                 GRHL2 
                 rs678347 
                 2.00E−08 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 GRM5 
                 rs518167 
                 2.00E−06 
                 2.24 
                 Bossini-Castillo L, PMID: 
               
               
                   
                   
                   
                   
                 24532677 
               
               
                 HLA 
                 rs12194148| 
                  5.00E−58| 
                 NR|NR 
                 Padyukov L, PMID: 
               
               
                   
                 rs2157337 
                 9.00E−52 
                   
                 21156761|Padyukov L, PMID: 
               
               
                   
                   
                   
                   
                 21156761 
               
               
                 HLA-B 
                 rs2596565 
                 9.00E−09 
                 1.40 
                 Bossini-Castillo L, PMID: 
               
               
                   
                   
                   
                   
                 24532677 
               
               
                 HLA-DQA1 
                 rs9271348| 
                  5.00E−07| 
                 1.28|NR| 
                 Bossini-Castillo L, PMID: 
               
               
                   
                 rs6457617| 
                  1.00E−09| 
                 2.10 
                 24532677|Julia A, PMID: 
               
               
                   
                 rs9275406 
                 3.00E−12 
                   
                 18668548|Negi S, PMID: 
               
               
                   
                   
                   
                   
                 23918589 
               
               
                 HLA-DQA2 
                 rs12525220| 
                  2.00E−13| 
                 2.87|NR| 
                 Jiang L, PMID: 24782177|Julia 
               
               
                   
                 rs6457617| 
                  1.00E−09| 
                 2.10 
                 A, PMID: 18668548|Negi 
               
               
                   
                 rs9275406 
                 3.00E−12 
                   
                 S, PMID: 23918589 
               
               
                 HLA-DQB1 
                 rs12525220| 
                  2.00E−13| 
                 2.87|2.10 
                 Jiang L, PMID: 24782177|Negi 
               
               
                   
                 rs9275406 
                 3.00E−12 
                   
                 S, PMID: 23918589 
               
               
                 HLA-DRB1 
                 rs9268839| 
                     1.00E−250| 
                 2.47|2.47| 
                 Okada Y, PMID: 
               
               
                   
                 rs9268839| 
                     1.00E−250| 
                 2.88|2.51| 
                 24390342|Okada Y, PMID: 
               
               
                   
                 rs6910071| 
                     1.00E−299| 
                 NR|3.62| 
                 24390342|Stahl E A, PMID: 
               
               
                   
                 rs7765379| 
                  5.00E−23| 
                 2.55|NR| 
                 20453842|Freudenberg J, PMID 
               
               
                   
                 rs13192471| 
                  2.00E−58| 
                 1.28 
                 21452313|Kochi Y, PMID: 
               
               
                   
                 rs660895| 
                     1.00E−108| 
                   
                 20453841|Plenge R M, PMID: 
               
               
                   
                 rs6457620| 
                     4.00E−186| 
                   
                 17804836|Raychaudhuri 
               
               
                   
                 rs615672| 
                  8.00E−27| 
                   
                 S, PMID: 18794853|WTCCC, 
               
               
                   
                 rs9271348 
                 5.00E−07 
                   
                 PMID: 17554300|Bossini- 
               
               
                   
                   
                   
                   
                 Castillo L, PMID: 24532677 
               
               
                 IFNGR2 
                 rs73194058 
                 1.00E−06 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 IGFBP1 
                 rs6956740 
                 5.00E−07 
                 NR 
                 Padyukov L, PMID: 21156761 
               
               
                 IKZF3 
                 chr17: 38031857| 
                  2.00E−12| 
                 1.09|1.10 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs2872507 
                 9.00E−07 
                   
                 E A, PMID: 20453842 
               
               
                 IL2 
                 rs45475795| 
                  4.00E−06| 
                 1.14|1.12 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs13119723 
                 7.00E−07 
                   
                 E A, PMID: 20453842 
               
               
                 IL20RB 
                 rs9826828 
                 9.00E−10 
                 1.44 
                 Okada Y, PMID: 24390342 
               
               
                 IL21 
                 rs45475795| 
                  4.00E−06| 
                 1.14|1.12 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs13119723 
                 7.00E−07 
                   
                 E A, PMID: 20453842 
               
               
                 IL2RA 
                 rs706778| 
                  5.00E−14| 
                 1.10|1.14| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs706778| 
                  1.00E−11| 
                 1.25|1.19 
                 E A, PMID: 20453842|Doroth??e 
               
               
                   
                 rs2228150| 
                  6.60E−06| 
                   
                 Diogo, PMID: 23261300|Orozco 
               
               
                   
                 rs2104286 
                 1.00E−06 
                   
                 G, PMID: 24449572 
               
               
                 IL2RB 
                 rs3218251 
                 6.00E−06 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 IL3 
                 rs657075 
                 6.00E−06 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 IL6R 
                 rs2228145 
                 4.00E−09 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 IL6ST 
                 rs6859219 
                 1.00E−11 
                 1.28 
                 Stahl E A, PMID: 20453842 
               
               
                 INPP5B 
                 rs28411352 
                 3.00E−12 
                 1.11 
                 Okada Y, PMID: 24390342 
               
               
                 intergenic 
                 rs12413578 
                 5.00E−08 
                 NR 
                 Okada Y, PMID: 24390342 
               
               
                 IRAK1 
                 rs5987194 
                 3.00E−12 
                 1.16 
                 Okada Y, PMID: 24390342 
               
               
                 IRF4 
                 rs9378815 
                 1.00E−07 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 IRF5 
                 chr7: 128580042| 
                  1.00E−14| 
                 1.12|1.19| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs10488631| 
                  4.00E−11| 
                 1.44 
                 E A, PMID: 20453842|Padyukov 
               
               
                   
                 rs3807306 
                 3.00E−07 
                   
                 L, PMID: 21156761 
               
               
                 IRF8 
                 rs13330176| 
                  1.00E−12| 
                 1.12|1.12 
                 Okada Y, PMID: 
               
               
                   
                 rs2280381 
                 2.00E−06 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 JAZF1 
                 rs67250450 
                 3.00E−09 
                 1.11 
                 Okada Y, PMID: 24390342 
               
               
                 KCNIP4 
                 rs6448119 
                 7.00E−06 
                 NR 
                 Padyukov L, PMID: 21156761 
               
               
                 KIF3 
                 rs17374222 
                 2.00E−06 
                 1.13 
                 Stahl E A, PMID: 20453842 
               
               
                 KIF5A 
                 rs1678542| 
                  1.00E−07| 
                 1.20|1.12 
                 Orozco G, PMID: 
               
               
                   
                 rs1678542 
                 9.00E−08 
                   
                 24449572|Raychaudhuri 
               
               
                   
                   
                   
                   
                 S, PMID: 18794853 
               
               
                 LBH 
                 rs10175798 
                 1.00E−09 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 LOC100506023 
                 rs2105325 
                 3.00E−11 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 LOC100506403 
                 rs8133843 
                 2.00E−08 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 LOC145837 
                 rs8026898 
                 4.00E−19 
                 1.15 
                 Okada Y, PMID: 24390342 
               
               
                 LOC339442 
                 rs12140275 
                 2.00E−09 
                 1.11 
                 Okada Y, PMID: 24390342 
               
               
                 MED1 
                 rs1877030 
                 2.00E−08 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 MHC 
                 rs7748270| 
                  1.00E−16| 
                 2.01|2.36| 
                 Jiang L, PMID: 
               
               
                   
                 rs6457617| 
                  5.00E−75| 
                 2.87 
                 24782177|WTCCC, PMID: 
               
               
                   
                 rs12525220 
                 2.00E−13 
                   
                 17554300|Jiang L, PMID: 
               
               
                   
                   
                   
                   
                 24782177 
               
               
                 MICA 
                 rs2596565 
                 9.00E−09 
                 1.40 
                 Bossini-Castillo L, PMID: 
               
               
                   
                   
                   
                   
                 24532677 
               
               
                 MMEL1 
                 chr1: 2523811| 
                  5.00E−09| 
                 1.10|1.12 
                 Okada Y, PMID: 
               
               
                   
                 rs3890745 
                 1.00E−07 
                   
                 24390342|Raychaudhuri 
               
               
                   
                   
                   
                   
                 S, PMID: 18794853 
               
               
                 MTF1 
                 rs28411352 
                 3.00E−12 
                 1.11 
                 Okada Y, PMID: 24390342 
               
               
                 NFKBIE 
                 rs2233424| 
                  1.00E−19| 
                 1.26|1.19 
                 Okada Y, PMID: 
               
               
                   
                 rs2233434 
                  6.00E−19| 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                 1.00E−15 
                   
                 22446963|Myouzen K, PMID: 
               
               
                   
                   
                   
                   
                 23028356 
               
               
                 OLIG3 
                 rs2230926| 
                  2.00E−06| 
                 1.31|1.22| 
                 Kochi Y, PMID: 
               
               
                   
                 rs6920220| 
                  1.00E−07| 
                 1.33 
                 20453841|Plenge R M, PMID: 
               
               
                   
                 rs10499194 
                 1.00E−09 
                   
                 17982456|Plenge R M, PMID: 
               
               
                   
                   
                   
                   
                 17982456 
               
               
                 P2RY10 
                 chrX: 78464616 
                 4.00E−08 
                 1.11 
                 Okada Y, PMID: 24390342 
               
               
                 PADI4 
                 rs2301888| 
                  1.00E−18| 
                 1.13|1.50 
                 Okada Y, PMID: 
               
               
                   
                 rs2240335 
                 2.00E−08 
                   
                 24390342|Freudenberg J, PMID: 
               
               
                   
                   
                   
                   
                 21452313 
               
               
                 PDE2A 
                 rs3781913 
                 6.00E−10 
                 1.12 
                 Okada Y, PMID: 22446963 
               
               
                 PIP4K2C 
                 rs1678542 
                 9.00E−08 
                 1.12 
                 Raychaudhuri S, PMID: 
               
               
                   
                   
                   
                   
                 18794853 
               
               
                 PLCL2 
                 rs4452313 
                 2.00E−10 
                 NR 
                 Okada Y, PMID: 24390342 
               
               
                 PLD4 
                 rs2582532| 
                  3.00E−07| 
                 1.17|1.15 
                 Okada Y, PMID: 
               
               
                   
                 rs2841277 
                 2.00E−14 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 POU3F1 
                 rs12131057 
                 4.00E−07 
                 1.16 
                 Stahl E A, PMID: 20453842 
               
               
                 PPIL4 
                 rs9373594 
                 3.00E−09 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 PRKCB1 
                 rs7404928 
                 4.00E−06 
                 1.08 
                 Okada Y, PMID: 22446963 
               
               
                 PRKCH 
                 rs3783782| 
                  2.00E−09| 
                 1.14|1.09 
                 Okada Y, PMID: 
               
               
                   
                 rs1957895 
                 4.00E−07 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 PRKCQ 
                 rs947474| 
                  3.00E−10| 
                 1.12|1.15| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs4750316 
                  2.00E−06| 
                 1.14 
                 E A, PMID: 
               
               
                   
                   
                 4.00E−06 
                   
                 20453842|Raychaudhuri 
               
               
                   
                   
                   
                   
                 S, PMID: 18794853 
               
               
                 PTPN11 
                 rs10774624 
                 7.00E−09 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 PTPN2 
                 rs8083786| 
                  2.00E−11| 
                 1.18|1.10 
                 Okada Y, PMID: 
               
               
                   
                 rs2847297 
                 2.00E−08 
                   
                 24390342|Okada Y, PMID: 
               
               
                   
                   
                   
                   
                 22446963 
               
               
                 PTPN22 
                 rs2476601| 
                     9.00E−170| 
                 1.80|1.94| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs2476601| 
                  9.00E−74|0| 
                 1.82|1.79| 
                 E A, PMID: 20453842|Doroth??e 
               
               
                   
                 rs6679677 
                  1.00E−08| 
                 1.98 
                 Diogo, PMID: 23261300|Padyukov 
               
               
                   
                   
                  6.00E−42| 
                   
                 L, PMID: 21156761|Raychaudhuri 
               
               
                   
                   
                 6.00E−25 
                   
                 S, PMID: 18794853|WTCCC, 
               
               
                   
                   
                   
                   
                 PMID: 17554300 
               
               
                 PVT1 
                 rs1516971 
                 1.00E−10 
                 1.15 
                 Okada Y, PMID: 24390342 
               
               
                 PXK 
                 rs73081554| 
                  5.00E−08| 
                 1.18|1.29 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs13315591 
                 5.00E−08 
                   
                 E A, PMID: 20453842 
               
               
                 RAD51B 
                 rs1950897 
                 5.00E−08 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 RAG1 
                 rs331463 
                 1.00E−07 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 RAG2 
                 rs331463 
                 1.00E−07 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 RASGRP1 
                 rs8032939 
                 2.00E−18 
                 1.13 
                 Okada Y, PMID: 24390342 
               
               
                 RBPJ 
                 rs874040| 
                  1.00E−16| 
                 1.14|1.19 
                 Stahl E A, PMID: 
               
               
                   
                 rs6448432 
                 4.00E−07 
                   
                 20453842|Orozco G, PMID: 
               
               
                   
                   
                   
                   
                 24449572 
               
               
                 RCAN1 
                 chr21: 35928240 
                 3.00E−07 
                 1.11 
                 Okada Y, PMID: 24390342 
               
               
                 REL 
                 rs34695944| 
                  2.00E−15| 
                 1.12|1.13| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs13031237| 
                  8.00E−07| 
                 NR 
                 E A, PMID: 20453842|Gregersen 
               
               
                   
                 rs13017599 
                 2.00E−12 
                   
                 P K, PMID: 19503088 
               
               
                 RNASEH2B 
                 rs3790022 
                 1.00E−06 
                  1.4925 
                 Bossini-Castillo L, PMID: 
               
               
                   
                   
                   
                   
                 24532677 
               
               
                 RPS12P4 
                 rs4305317 
                 2.00E−06 
                 1.45 
                 Padyukov L, PMID: 21156761 
               
               
                 RTKN2 
                 rs6479800| 
                  4.00E−06| 
                 1.19|NR 
                 Okada Y, PMID: 
               
               
                   
                 rs3125734 
                 5.00E−09 
                   
                 24390342|Myouzen K, PMID: 
               
               
                   
                   
                   
                   
                 23028356 
               
               
                 RUNX1 
                 rs8133843 
                 2.00E−08 
                 1.09 
                 Okada Y, PMID: 24390342 
               
               
                 SALL3 
                 rs2002842 
                 6.00E−06 
                 1.61 
                 Julia A, PMID: 18668548 
               
               
                 SFTPD 
                 rs726288 
                 9.00E−09 
                 1.22 
                 Okada Y, PMID: 24390342 
               
               
                 SH2B3 
                 rs10774624| 
                  7.00E−09| 
                 1.09|1.08 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs3184504 
                 6.00E−06 
                   
                 E A, PMID: 20453842 
               
               
                 SMIM21 
                 rs1943199 
                 2.00E−08 
                 1.94 
                 Bossini-Castillo L, PMID: 
               
               
                   
                   
                   
                   
                 24532677 
               
               
                 SPRED2 
                 rs1858037| 
                  1.00E−08| 
                 1.19|1.13 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs934734 
                  5.00E−10| 
                   
                 E A, PMID: 20453842|Jiang 
               
               
                   
                   
                 2.00E−08 
                   
                 L, PMID: 24782177 
               
               
                 STAT4 
                 rs11889341| 
                  1.00E−12| 
                 1.12|1.16 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs7574865 
                  3.00E−07| 
                   
                 E A, PMID: 20453842|Kochi 
               
               
                   
                   
                 2.00E−06 
                   
                 Y, PMID: 20453841 
               
               
                 SYNGR1 
                 rs909685 
                 1.00E−16 
                 1.13 
                 Okada Y, PMID: 24390342 
               
               
                 TAGAP 
                 rs2451258 
                 2.00E−10 
                 1.10 
                 Okada Y, PMID: 24390342 
               
               
                 TEC 
                 rs2664035 
                 1.00E−07 
                 1.07 
                 Okada Y, PMID: 24390342 
               
               
                 TNFAIP3 
                 rs7752903| 
                  2.00E−20| 
                 1.41|1.22| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs6920220| 
                  9.00E−13| 
                 1.38|1.33 
                 E A, PMID: 20453842|Plenge 
               
               
                   
                 rs2230926| 
                  1.00E−07| 
                   
                 R M, PMID: 17982456|Doroth??e 
               
               
                   
                 rs10499194 
                  6.80E−14| 
                   
                 Diogo, PMID: 23261300|Kochi 
               
               
                   
                   
                  2.00E−06| 
                   
                 Y, PMID: 20453841|Plenge 
               
               
                   
                   
                 1.00E−09 
                   
                 R M, PMID: 17982456 
               
               
                 TNFRSF14 
                 chr1: 2523811| 
                  5.00E−09| 
                 1.10|1.12| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs3890745 
                  4.00E−06| 
                 NR|1.12 
                 E A, PMID: 20453842|Orozco 
               
               
                   
                   
                  1.00E−06| 
                   
                 G, PMID: 
               
               
                   
                   
                 1.00E−07 
                   
                 24449572|Raychaudhuri 
               
               
                   
                   
                   
                   
                 S, PMID: 18794853 
               
               
                 TNFRSF9 
                 rs227163 
                 3.00E−09 
                 1.11 
                 Okada Y, PMID: 24390342 
               
               
                 TPD52 
                 rs998731 
                 2.00E−08 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 TRAF1 
                 rs10985070| 
                  4.00E−09| 
                 1.09|1.13| 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs3761847| 
                  2.00E−07| 
                 1.10|NR|NR 
                 E A, PMID: 20453842|Doroth??e 
               
               
                   
                 rs2239657| 
                  5.40E−08| 
                   
                 Diogo, PMID: 23261300|Gregersen 
               
               
                   
                 rs881375| 
                  4.00E−08| 
                   
                 P K, PMID: 19503088|Jiang 
               
               
                   
                 rs2072438 
                 3.00E−09 
                   
                 L, PMID: 24782177 
               
               
                 TRAF1-C5 
                 rs3761847 
                 4.00E−14 
                 1.32 
                 Plenge R M, PMID: 17804836 
               
               
                 TRAF6 
                 rs331463 
                 1.00E−07 
                 1.12 
                 Okada Y, PMID: 24390342 
               
               
                 TRHDE 
                 rs12831974 
                 6.00E−06 
                 1.27 
                 Freudenberg J, PMID: 21452313 
               
               
                 TXNDC11 
                 rs4780401 
                 4.00E−08 
                 1.07 
                 Okada Y, PMID: 24390342 
               
               
                 TYK2 
                 rs34536443 
                 5.00E−16 
                 1.46 
                 Okada Y, PMID: 24390342 
               
               
                 UBASH3A 
                 rs1893592| 
                  7.00E−12| 
                 1.11|1.11 
                 Okada Y, PMID: 24390342|Stahl 
               
               
                   
                 rs11203203 
                 4.00E−06 
                   
                 E A, PMID: 20453842 
               
               
                 UBE2L3 
                 rs11089637 
                 2.00E−07 
                 1.10 
                 Okada Y, PMID: 24390342 
               
               
                 WDFY4 
                 rs2671692 
                 3.00E−09 
                 1.07 
                 Okada Y, PMID: 24390342 
               
               
                 YDJC 
                 rs11089637 
                 2.00E−07 
                 1.10 
                 Okada Y, PMID: 24390342 
               
               
                 ZNF438 
                 rs793108 
                 1.00E−09 
                 1.08 
                 Okada Y, PMID: 24390342 
               
               
                 ZNF774 
                 rs6496667 
                 1.00E−06 
                 1.09 
                 Okada Y, PMID: 22446963 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 7 
               
             
            
               
                   
               
               
                 Clinical conditions associated with group 2 variants in RA and control comparison. 
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                   
                   
                 Clinical conditions reported in 
                   
               
               
                 chr 
                 pos 
                 id 
                 ref 
                 alt 
                 gene 
                 LR 
                 ClinVar 
                 Function 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 10 
                 101829514 
                 rs61751507 
                 C 
                 T 
                 CPN1 
                 T 
                 Anaphylotoxin inactivator 
                 Peptide hormone metabolism; 
               
               
                   
                   
                   
                   
                   
                   
                   
                 deficiency 
                 Protects the body from potent vasoactive 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 and inflammatory peptides. 
               
               
                 11 
                 18291302 
                 rs79681911 
                 G 
                 A 
                 SAA1 
                 T 
                 Serum amyloid a variant 
                 Activated TLR4 signaling; Cytokine 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Signaling in Immune system. 
               
               
                 3 
                 133476698 
                 rs41295774 
                 A 
                 G 
                 TF 
                 T 
                 Atransferrinemia 
                 Vesicle-mediated transport; Iron 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 metabolism in placenta. 
               
               
                 5 
                 41862758 
                 rs75134564 
                 G 
                 A 
                 OXCT1 
                 D 
                 Succinyl-CoA acetoacetate 
                 Ketone body metabolism; 
               
               
                   
                   
                   
                   
                   
                   
                   
                 transferase deficiency 
                 Regulation of lipid metabolism. 
               
               
                 7 
                 44104839 
                 rs77938727 
                 C 
                 T 
                 PGAM2 
                 D 
                 Glycogen storage disease 
                 Glycosaminoglycan metabolism; 
               
               
                   
                   
                   
                   
                   
                   
                   
                 type X 
                 Immune response in T lymphocytes. 
               
               
                 X 
                 38229135 
                 rs72554348 
                 G 
                 C 
                 OTC 
                 . 
                 Ornithine carbamoltransferase 
                 Carbon metabolism; Viral mRNA 
               
               
                   
                   
                   
                   
                   
                   
                   
                 deficiency 
                 Translation. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 8 
               
             
            
               
                   
               
               
                 Pathway analysis for candidate genes 
               
               
                 conferring susceptibility to RA 
               
            
           
           
               
               
               
            
               
                 Pathway 
                 P value 
                 Genes 
               
               
                   
               
               
                 Based on genes identified 
                   
                   
               
               
                 in comparison of RA 
               
               
                 patients and controls 
               
               
                 ECM-receptor 
                 2.1 × 10 −3   
                 COL4A4, COL6A5, COL11A1, 
               
               
                 interaction 
                   
                 COL11A2, HSPG2, ITGB5, 
               
               
                   
                   
                 LAMC1, THBS1 
               
               
                 Protein digestion and 
                 2.3 × 10 −3   
                 ATP1A1, ATP1A4, COL4A4, 
               
               
                 absorption 
                   
                 COL6A5, COL11A1, COL11A2, 
               
               
                   
                   
                 MME, PRCP 
               
               
                 Focal adhesion 
                 2.8 × 10 −2   
                 RASGRF1, COL4A4, COL6A5, 
               
               
                   
                   
                 COL11A1, COL11A2, FLNB, 
               
               
                   
                   
                 ITGB5, LAMC1, MYL5, THBS1 
               
               
                 Glycerophospholipid 
                 4.8 × 10 −2   
                 CHAT, GPAT4, LPIN3, 
               
               
                 metabolism 
                   
                 LPCAT1, MBOAT1, PTDSS2 
               
               
                 Based on genes only 
               
               
                 identified in disease 
               
               
                 duration comparison 
               
               
                 of RA patients 
               
               
                 Olfactory 
                 1.2 × 10 −2   
                 OR14C36, OR4A15, OR52N4, 
               
               
                 transduction 
                   
                 OR6C74, OR6C75, OR7G3, 
               
               
                   
                   
                 OR9K2 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 9 
               
             
            
               
                   
               
               
                 Candidate variant list from RA disease duration comparison. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                 Total No. 
                   
                   
                   
               
               
                   
                 Gene 
                 of 
                 No. alt 
                   
                 Variant 
               
               
                   
                 burden 
                 alleles 
                 alleles 
                 No. of ≥3- 
                 allele 
               
               
                   
                 ratio 
                 in gene 
                 in genes 
                 Year 
                 frequency 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                   
                   
                   
                 KG East 
                 ≤1- 
                   
                 ≥3- 
                 ≤1- 
                 ≥3- 
                 cases with 
                 KG 
               
               
                 group 
                 chr 
                 pos 
                 id 
                 ref 
                 alt 
                 gene 
                 LR 
                 Asia 
                 Year 
                 ≤1-Year 
                 Year 
                 Year 
                 Year 
                 alt alleles 
                 East Asia 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 2 
                 10 
                 101829514 
                 rs61751507 
                 C 
                 T 
                 CPN1 
                 T 
                 2.28 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0248 
               
               
                   
               
               
                 2 
                 1 
                 115220086 
                 rs121912682 
                 C 
                 T 
                 AMPD1 
                 D 
                 4.57 
                 . 
                 52 
                 46 
                 0 
                 3 
                 3 
                 0.0109 
               
               
                   
               
               
                 2 
                 11 
                 18291302 
                 rs79681911 
                 G 
                 A 
                 SAA1 
                 T 
                 3.04 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0198 
               
               
                   
               
               
                 2 
                 5 
                 149212243 
                 rs7732671 
                 G 
                 C 
                 PPARGC1B 
                 T 
                 1.76 
                 1.88 
                 52 
                 46 
                 3 
                 5 
                 5 
                 0.0625 
               
               
                   
               
               
                 2 
                 7 
                 138417791 
                 rs3807153 
                 A 
                 G 
                 ATP6V0A4 
                 T 
                 1.71 
                 . 
                 52 
                 46 
                 0 
                 3 
                 3 
                 0.0516 
               
               
                   
               
               
                 2 
                 X 
                 38229135 
                 rs72554348 
                 G 
                 C 
                 OTC 
                 . 
                 4.61 
                 4.35 
                 50 
                 46 
                 1 
                 4 
                 3 
                 0.0144 
               
               
                   
               
               
                 4 
                 10 
                 135086331 
                 rs536126291 
                 C 
                 T 
                 ADAM8 
                 . 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 10 
                 135087305 
                 rs3810960 
                 G 
                 A 
                 ADAM8 
                 . 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 10 
                 25144247 
                 rs199794379 
                 A 
                 G 
                 PRTFDC1 
                 D 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 10 
                 25147326 
                 rs199983667 
                 C 
                 A 
                 PRTFDC1 
                 D 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 10 
                 70987060 
                 rs10823320 
                 A 
                 G 
                 HKDC1 
                 D 
                 18.26 
                 . 
                 208 
                 184 
                 0 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 10 
                 70992606 
                 rs575180113 
                 G 
                 A 
                 HKDC1 
                 D 
                 18.26 
                 . 
                 208 
                 184 
                 0 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 10 
                 71002935 
                 rs185650169 
                 C 
                 T 
                 HKDC1 
                 . 
                 18.26 
                 . 
                 208 
                 184 
                 0 
                 4 
                 4 
                 0.0069 
               
               
                   
               
               
                 4 
                 10 
                 71021004 
                 rs143285779 
                 C 
                 T 
                 HKDC1 
                 D 
                 18.26 
                 . 
                 208 
                 184 
                 0 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 1 
                 100174455 
                 rs192583899 
                 T 
                 C 
                 FRRS1 
                 . 
                 3.04 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 1 
                 100177969 
                 rs187278122 
                 A 
                 G 
                 FRRS1 
                 . 
                 3.04 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 11 
                 130060344 
                 rs199819888 
                 C 
                 T 
                 ST14 
                 . 
                 1.52 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 11 
                 130064039 
                 rs76687780 
                 C 
                 G 
                 ST14 
                 . 
                 1.52 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 1 
                 11826069 
                 rs560354825 
                 G 
                 C 
                 C1orf167 
                 D 
                 6.09 
                 1.51 
                 156 
                 138 
                 3 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 1 
                 11826663 
                 rs374366683 
                 G 
                 A 
                 C1orf167 
                 . 
                 6.09 
                 1.51 
                 156 
                 138 
                 3 
                 4 
                 4 
                 0.004 
               
               
                   
               
               
                 4 
                 1 
                 11844289 
                 rs76627351 
                 C 
                 T 
                 C1orf167 
                 . 
                 6.09 
                 1.51 
                 156 
                 138 
                 3 
                 4 
                 4 
                 0.0079 
               
               
                   
               
               
                 4 
                 1 
                 146759364 
                 . 
                 C 
                 T 
                 CHD1L 
                 . 
                 13.7 
                 . 
                 48 
                 46 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 11 
                 74716666 
                 rs202090872 
                 G 
                 C 
                 NEU3 
                 D 
                 9.13 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 11 
                 74716935 
                 rs200629627 
                 G 
                 A 
                 NEU3 
                 D 
                 9.13 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 11 
                 74717001 
                 rs539514716 
                 C 
                 T 
                 NEU3 
                 D 
                 9.13 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 1 
                 176853472 
                 rs79630456 
                 C 
                 T 
                 ASTN1 
                 . 
                 4.57 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0089 
               
               
                   
               
               
                 4 
                 1 
                 19566783 
                 rs201918168 
                 C 
                 T 
                 EMC1 
                 . 
                 3.04 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0079 
               
               
                   
               
               
                 4 
                 1 
                 197070906 
                 rs118010078 
                 C 
                 T 
                 ASPM 
                 D 
                 6.85 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 1 
                 197072871 
                 rs144969324 
                 C 
                 T 
                 ASPM 
                 D 
                 6.85 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 3 
                 0.005 
               
               
                   
               
               
                 4 
                 12 
                 21011481 
                 rs145334570 
                 C 
                 A 
                 SLCO1B3 
                 D 
                 6.85 
                 . 
                 52 
                 46 
                 0 
                 3 
                 3 
                 0.0099 
               
               
                   
               
               
                 4 
                 1 
                 36056256 
                 rs114404250 
                 G 
                 A 
                 TFAP2E 
                 D 
                 6.85 
                 . 
                 52 
                 46 
                 0 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 14 
                 21793077 
                 rs543867152 
                 C 
                 T 
                 RPGRIP1 
                 D 
                 13.7 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 14 
                 21793236 
                 rs7157052 
                 G 
                 A 
                 RPGRIP1 
                 . 
                 13.7 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 14 
                 94703898 
                 rs148831396 
                 G 
                 T 
                 PPP4R4 
                 . 
                 9.13 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.005 
               
               
                   
               
               
                 4 
                 15 
                 39876498 
                 rs200938835 
                 T 
                 C 
                 THBS1 
                 . 
                 4.57 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 15 
                 39881204 
                 rs200366954 
                 A 
                 G 
                 THBS1 
                 D 
                 4.57 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 15 
                 39886402 
                 rs185847032 
                 G 
                 A 
                 THBS1 
                 . 
                 4.57 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 15 
                 48512855 
                 rs116848967 
                 G 
                 A 
                 SLC12A1 
                 D 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 15 
                 48566800 
                 rs201516084 
                 T 
                 C 
                 SLC12A1 
                 D 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.005 
               
               
                   
               
               
                 4 
                 15 
                 79298783 
                 rs182075492 
                 G 
                 C 
                 RASGRF1 
                 . 
                 3.04 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.005 
               
               
                   
               
               
                 4 
                 16 
                 27492392 
                 rs200888316 
                 C 
                 T 
                 GTF3C1 
                 . 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 16 
                 27494449 
                 rs536534746 
                 G 
                 A 
                 GTF3C1 
                 . 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 16 
                 57935248 
                 rs374813501 
                 C 
                 G 
                 CNGB1 
                 . 
                 6.85 
                 3.39 
                 208 
                 184 
                 1 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 16 
                 57984441 
                 rs146170855 
                 C 
                 T 
                 CNGB1 
                 D 
                 6.85 
                 3.39 
                 208 
                 184 
                 1 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 16 
                 57993840 
                 rs201703193 
                 C 
                 T 
                 CNGB1 
                 D 
                 6.85 
                 3.39 
                 208 
                 184 
                 1 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 16 
                 57996967 
                 rs570828500 
                 G 
                 A 
                 CNGB1 
                 D 
                 6.85 
                 3.39 
                 208 
                 184 
                 1 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 1 
                 6638781 
                 rs201116489 
                 C 
                 T 
                 TAS1R1 
                 D 
                 4.57 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 1 
                 6638995 
                 rs150612979 
                 C 
                 T 
                 TAS1R1 
                 D 
                 4.57 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 16 
                 70916556 
                 rs9932260 
                 G 
                 A 
                 HYDIN 
                 . 
                 18.26 
                 1.51 
                 52 
                 46 
                 3 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 17 
                 10398298 
                 rs140873918 
                 G 
                 T 
                 MYH1 
                 D 
                 3.04 
                 2.26 
                 416 
                 368 
                 2 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 17 
                 10401217 
                 rs148588034 
                 C 
                 T 
                 MYH1 
                 D 
                 3.04 
                 2.26 
                 416 
                 368 
                 2 
                 4 
                 4 
                 0.0069 
               
               
                   
               
               
                 4 
                 17 
                 10402103 
                 rs3744564 
                 G 
                 A 
                 MYH1 
                 D 
                 3.04 
                 2.26 
                 416 
                 368 
                 2 
                 4 
                 4 
                 0.003 
               
               
                   
               
               
                 4 
                 17 
                 10408323 
                 rs534110923 
                 G 
                 C 
                 MYH1 
                 D 
                 3.04 
                 2.26 
                 416 
                 368 
                 2 
                 4 
                 4 
                 0.005 
               
               
                   
               
               
                 4 
                 17 
                 10408380 
                 rs191339081 
                 T 
                 A 
                 MYH1 
                 D 
                 3.04 
                 2.26 
                 416 
                 368 
                 2 
                 4 
                 4 
                 0.005 
               
               
                   
               
               
                 4 
                 17 
                 10412897 
                 rs534998190 
                 C 
                 T 
                 MYH1 
                 D 
                 3.04 
                 2.26 
                 416 
                 368 
                 2 
                 4 
                 4 
                 0.002 
               
               
                   
               
               
                 4 
                 17 
                 10417137 
                 rs141592934 
                 C 
                 T 
                 MYH1 
                 . 
                 3.04 
                 2.26 
                 416 
                 368 
                 2 
                 4 
                 4 
                 0.0069 
               
               
                   
               
               
                 4 
                 17 
                 10419751 
                 rs535620022 
                 C 
                 T 
                 MYH1 
                 . 
                 3.04 
                 2.26 
                 416 
                 368 
                 2 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 10541353 
                 rs201166774 
                 G 
                 A 
                 MYH3 
                 . 
                 2.28 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 17 
                 10558169 
                 rs374786690 
                 G 
                 C 
                 MYH3 
                 . 
                 2.28 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 17 
                 26856125 
                 rs188424977 
                 G 
                 A 
                 FOXN1 
                 D 
                 3.04 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 17 
                 26861343 
                 rs200401045 
                 C 
                 T 
                 FOXN1 
                 . 
                 3.04 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 26864171 
                 rs187814037 
                 C 
                 T 
                 FOXN1 
                 D 
                 3.04 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.005 
               
               
                   
               
               
                 4 
                 17 
                 46878711 
                 rs184362955 
                 G 
                 A 
                 TTLL6 
                 D 
                 13.7 
                 . 
                 52 
                 46 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 48245315 
                 rs186669379 
                 C 
                 T 
                 SGCA 
                 D 
                 1.83 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 17 
                 48245924 
                 rs200945974 
                 G 
                 A 
                 SGCA 
                 D 
                 1.83 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 48246530 
                 rs138254713 
                 G 
                 A 
                 SGCA 
                 D 
                 1.83 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.0079 
               
               
                   
               
               
                 4 
                 17 
                 67079395 
                 rs117323775 
                 G 
                 T 
                 ABCA6 
                 D 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 67121109 
                 rs200376492 
                 A 
                 G 
                 ABCA6 
                 D 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.0079 
               
               
                   
               
               
                 4 
                 17 
                 73827216 
                 rs140184929 
                 C 
                 T 
                 UNC13D 
                 D 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 17 
                 73839609 
                 rs527842266 
                 C 
                 G 
                 UNC13D 
                 . 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 18 
                 72179676 
                 rs201407255 
                 C 
                 T 
                 CNDP2 
                 . 
                 4.57 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 18 
                 72185883 
                 rs201217537 
                 G 
                 A 
                 CNDP2 
                 . 
                 4.57 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.0069 
               
               
                   
               
               
                 4 
                 19 
                 38934191 
                 rs192495718 
                 C 
                 G 
                 RYR1 
                 . 
                 1.96 
                 . 
                 364 
                 322 
                 0 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 19 
                 38948941 
                 rs573737900 
                 C 
                 T 
                 RYR1 
                 . 
                 1.96 
                 . 
                 364 
                 322 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 19 
                 38964364 
                 rs551509462 
                 G 
                 C 
                 RYR1 
                 D 
                 1.96 
                 . 
                 364 
                 322 
                 0 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 19 
                 38981375 
                 rs78851466 
                 A 
                 G 
                 RYR1 
                 . 
                 1.96 
                 . 
                 364 
                 322 
                 0 
                 3 
                 3 
                 0.0089 
               
               
                   
               
               
                 4 
                 19 
                 39014545 
                 rs200939091 
                 G 
                 A 
                 RYR1 
                 . 
                 1.96 
                 . 
                 364 
                 322 
                 0 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 19 
                 39014556 
                 rs370630840 
                 C 
                 T 
                 RYR1 
                 D 
                 1.96 
                 . 
                 364 
                 322 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 19 
                 39018329 
                 rs538497899 
                 C 
                 T 
                 RYR1 
                 D 
                 1.96 
                 . 
                 364 
                 322 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 19 
                 8140232 
                 rs145316149 
                 G 
                 A 
                 FBN3 
                 D 
                 3.04 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 19 
                 8150331 
                 rs142940013 
                 G 
                 A 
                 FBN3 
                 D 
                 3.04 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 19 
                 8155130 
                 rs183278638 
                 G 
                 A 
                 FBN3 
                 D 
                 3.04 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 19 
                 8188820 
                 rs145435433 
                 C 
                 T 
                 FBN3 
                 D 
                 3.04 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 19 
                 8979212 
                 rs149481309 
                 C 
                 T 
                 MUC16 
                 . 
                 5.71 
                 2.83 
                 208 
                 184 
                 2 
                 5 
                 5 
                 0.0089 
               
               
                   
               
               
                 4 
                 19 
                 9002496 
                 rs553074376 
                 C 
                 T 
                 MUC16 
                 . 
                 5.71 
                 2.83 
                 208 
                 184 
                 2 
                 5 
                 5 
                 0.006 
               
               
                   
               
               
                 4 
                 19 
                 9043416 
                 rs17417801 
                 G 
                 A 
                 MUC16 
                 . 
                 5.71 
                 2.83 
                 208 
                 184 
                 2 
                 5 
                 5 
                 0.0079 
               
               
                   
               
               
                 4 
                 19 
                 9056878 
                 rs200934751 
                 GAGA 
                 G 
                 MUC16 
                 . 
                 5.71 
                 2.83 
                 208 
                 184 
                 2 
                 5 
                 5 
                 0.0069 
               
               
                   
               
               
                 4 
                 20 
                 21142998 
                 rs191064527 
                 G 
                 A 
                 KIZ 
                 . 
                 1.96 
                 . 
                 156 
                 138 
                 0 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 20 
                 21143067 
                 rs116937124 
                 T 
                 C 
                 KIZ 
                 . 
                 1.96 
                 . 
                 156 
                 138 
                 0 
                 3 
                 3 
                 0.006 
               
               
                   
               
               
                 4 
                 20 
                 39788407 
                 rs201733074 
                 T 
                 C 
                 PLCG1 
                 . 
                 3.04 
                 4.52 
                 156 
                 138 
                 1 
                 4 
                 4 
                 0.0079 
               
               
                   
               
               
                 4 
                 20 
                 39797820 
                 rs547025579 
                 GACCAGAACC 
                 G 
                 PLCG1 
                 . 
                 3.04 
                 4.52 
                 156 
                 138 
                 1 
                 4 
                 4 
                 0.0069 
               
               
                   
                   
                   
                   
                 (SEQ ID NO: 9) 
               
               
                   
               
               
                 4 
                 20 
                 39798092 
                 rs183538599 
                 C 
                 T 
                 PLCG1 
                 . 
                 3.04 
                 4.52 
                 156 
                 138 
                 1 
                 4 
                 4 
                 0.0079 
               
               
                   
               
               
                 4 
                 21 
                 10908822 
                 rs546417233 
                 T 
                 C 
                 TPTE 
                 . 
                 9.13 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 21 
                 10908886 
                 rs532224827 
                 T 
                 C 
                 TPTE 
                 . 
                 9.13 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 21 
                 10920159 
                 rs557556075 
                 G 
                 T 
                 TPTE 
                 . 
                 9.13 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 21 
                 10970067 
                 rs547492558 
                 T 
                 C 
                 TPTE 
                 . 
                 9.13 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 21 
                 43621840 
                 rs564785493 
                 T 
                 A 
                 ABCG1 
                 . 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 21 
                 43636306 
                 rs149713099 
                 C 
                 T 
                 ABCG1 
                 . 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.0079 
               
               
                   
               
               
                 4 
                 2 
                 170038100 
                 rs140572511 
                 G 
                 A 
                 LRP2 
                 D 
                 11.41 
                 . 
                 260 
                 230 
                 0 
                 5 
                 5 
                 0.002 
               
               
                   
               
               
                 4 
                 2 
                 170038761 
                 rs3213760 
                 C 
                 T 
                 LRP2 
                 D 
                 11.41 
                 . 
                 260 
                 230 
                 0 
                 5 
                 5 
                 0.004 
               
               
                   
               
               
                 4 
                 2 
                 170042008 
                 rs563916043 
                 C 
                 T 
                 LRP2 
                 . 
                 11.41 
                 . 
                 260 
                 230 
                 0 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 170058290 
                 rs138382534 
                 C 
                 T 
                 LRP2 
                 D 
                 11.41 
                 . 
                 260 
                 230 
                 0 
                 5 
                 5 
                 0.003 
               
               
                   
               
               
                 4 
                 2 
                 170163815 
                 rs142594441 
                 C 
                 T 
                 LRP2 
                 D 
                 11.41 
                 . 
                 260 
                 230 
                 0 
                 5 
                 5 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 179404792 
                 rs556524594 
                 C 
                 T 
                 TTN 
                 . 
                 4.57 
                 1.7 
                 416 
                 368 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 179425208 
                 rs142478636 
                 G 
                 T 
                 TTN 
                 D 
                 4.57 
                 1.7 
                 416 
                 368 
                 2 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 2 
                 179430305 
                 rs185887755 
                 G 
                 A 
                 TTN 
                 D 
                 4.57 
                 1.7 
                 416 
                 368 
                 2 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 2 
                 179437342 
                 rs567446185 
                 C 
                 T 
                 TTN 
                 D 
                 4.57 
                 1.7 
                 416 
                 368 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 179481839 
                 rs144688960 
                 C 
                 A 
                 TTN 
                 . 
                 4.57 
                 1.7 
                 416 
                 368 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 179504772 
                 rs551963261 
                 C 
                 T 
                 TTN 
                 . 
                 4.57 
                 1.7 
                 416 
                 368 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 179577222 
                 rs186857044 
                 C 
                 A 
                 TTN 
                 D 
                 4.57 
                 1.7 
                 416 
                 368 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 179585717 
                 rs367826445 
                 C 
                 T 
                 TTN 
                 D 
                 4.57 
                 1.7 
                 416 
                 368 
                 2 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 2 
                 203058233 
                 rs13024221 
                 T 
                 C 
                 KIAA2012 
                 . 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 2 
                 203059076 
                 rs141298049 
                 G 
                 A 
                 KIAA2012 
                 . 
                 9.13 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 22 
                 31522450 
                 rs150976596 
                 G 
                 A 
                 INPP5J 
                 D 
                 4.57 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 3 
                 0.0099 
               
               
                   
               
               
                 4 
                 22 
                 31522715 
                 rs370874308 
                 A 
                 T 
                 INPP5J 
                 . 
                 4.57 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 22 
                 32614713 
                 rs78144589 
                 C 
                 T 
                 SLC5A4 
                 . 
                 6.85 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 3 
                 0.0099 
               
               
                   
               
               
                 4 
                 22 
                 32631002 
                 rs554791323 
                 T 
                 C 
                 SLC5A4 
                 D 
                 6.85 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 70031769 
                 rs193084283 
                 A 
                 G 
                 ANXA4 
                 . 
                 1.83 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.0079 
               
               
                   
               
               
                 4 
                 2 
                 70039849 
                 rs184226986 
                 G 
                 A 
                 ANXA4 
                 . 
                 1.83 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.0079 
               
               
                   
               
               
                 4 
                 2 
                 71801442 
                 rs147483765 
                 C 
                 T 
                 DYSF 
                 D 
                 3.04 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 2 
                 71901318 
                 rs573892877 
                 C 
                 G 
                 DYSF 
                 . 
                 3.04 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 2 
                 71901432 
                 rs144355449 
                 C 
                 T 
                 DYSF 
                 . 
                 3.04 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 3 
                 130282510 
                 rs150427289 
                 T 
                 C 
                 COL6A6 
                 . 
                 2.28 
                 1.51 
                 208 
                 184 
                 3 
                 4 
                 4 
                 0.0089 
               
               
                   
               
               
                 4 
                 3 
                 130286067 
                 rs145020873 
                 A 
                 G 
                 COL6A6 
                 D 
                 2.28 
                 1.51 
                 208 
                 184 
                 3 
                 4 
                 4 
                 0.0099 
               
               
                   
               
               
                 4 
                 3 
                 130289976 
                 rs200963433 
                 C 
                 T 
                 COL6A6 
                 D 
                 2.28 
                 1.51 
                 208 
                 184 
                 3 
                 4 
                 4 
                 0.004 
               
               
                   
               
               
                 4 
                 3 
                 130346196 
                 rs117951912 
                 G 
                 A 
                 COL6A6 
                 D 
                 2.28 
                 1.51 
                 208 
                 184 
                 3 
                 4 
                 4 
                 0.0069 
               
               
                   
               
               
                 4 
                 3 
                 148904379 
                 rs555339346 
                 C 
                 G 
                 CP 
                 D 
                 9.13 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 3 
                 148917507 
                 rs17847018 
                 T 
                 C 
                 CP 
                 D 
                 9.13 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 3 
                 148930242 
                 rs563241895 
                 A 
                 T 
                 CP 
                 D 
                 9.13 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 3 
                 183822730 
                 rs560673114 
                 C 
                 CATTCCTCT 
                 HTR3E 
                 . 
                 2.28 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.0089 
               
               
                   
               
               
                 4 
                 3 
                 183823729 
                 rs187832026 
                 G 
                 T 
                 HTR3E 
                 D 
                 2.28 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.0069 
               
               
                   
               
               
                 4 
                 3 
                 183823919 
                 rs532417196 
                 T 
                 C 
                 HTR3E 
                 D 
                 2.28 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 3 
                 2928719 
                 rs184171731 
                 A 
                 C 
                 CNTN4 
                 . 
                 6.85 
                 1.7 
                 156 
                 138 
                 2 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 3 
                 3080611 
                 rs10510251 
                 G 
                 C 
                 CNTN4 
                 . 
                 6.85 
                 1.7 
                 156 
                 138 
                 2 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 3 
                 3081959 
                 rs339284 
                 T 
                 C 
                 CNTN4 
                 . 
                 6.85 
                 1.7 
                 156 
                 138 
                 2 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 3 
                 62309627 
                 rs1881268 
                 G 
                 C 
                 C3orf14 
                 . 
                 4.57 
                 . 
                 104 
                 92 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 3 
                 62317022 
                 rs186089632 
                 C 
                 A 
                 C3orf14 
                 . 
                 4.57 
                 . 
                 104 
                 92 
                 0 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 4 
                 106158550 
                 rs141975400 
                 G 
                 T 
                 TET2 
                 . 
                 4.57 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.005 
               
               
                   
               
               
                 4 
                 4 
                 6596385 
                 rs3216941 
                 AC 
                 A 
                 MAN2B2 
                 . 
                 9.13 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 4 
                 983115 
                 rs143381873 
                 G 
                 A 
                 SLC26A1 
                 D 
                 4.57 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.005 
               
               
                   
               
               
                 4 
                 4 
                 983342 
                 rs201608921 
                 C 
                 T 
                 SLC26A1 
                 D 
                 4.57 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 4 
                 983810 
                 rs563866785 
                 G 
                 A 
                 SLC26A1 
                 D 
                 4.57 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 4 
                 984938 
                 rs139024319 
                 G 
                 A 
                 SLC26A1 
                 D 
                 4.57 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 5 
                 1495038 
                 rs201521332 
                 G 
                 A 
                 LPCAT1 
                 . 
                 9.55 
                 2.36 
                 52 
                 44 
                 1 
                 2 
                 2 
                 0.0069 
               
               
                   
               
               
                 4 
                 5 
                 180477285 
                 rs200884524 
                 C 
                 T 
                 BTNL9 
                 . 
                 4.57 
                 . 
                 104 
                 92 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 5 
                 180483533 
                 rs373494500 
                 T 
                 C 
                 BTNL9 
                 . 
                 4.57 
                 . 
                 104 
                 92 
                 0 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 6 
                 169622491 
                 rs138932100 
                 G 
                 A 
                 THBS2 
                 D 
                 2.28 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 6 
                 169623562 
                 rs182173220 
                 G 
                 A 
                 THBS2 
                 D 
                 2.28 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 6 
                 169628312 
                 rs368102843 
                 C 
                 T 
                 THBS2 
                 D 
                 2.28 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 6 
                 169646282 
                 rs76393784 
                 A 
                 T 
                 THBS2 
                 . 
                 2.28 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 6 
                 35438350 
                 rs187631484 
                 C 
                 T 
                 MIR7111 
                 . 
                 4.57 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0069 
               
               
                   
               
               
                 4 
                 6 
                 35438350 
                 rs187631484 
                 C 
                 T 
                 RPL10A 
                 . 
                 4.57 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0069 
               
               
                   
               
               
                 4 
                 6 
                 43160731 
                 rs568565110 
                 C 
                 G 
                 CUL9 
                 . 
                 9.13 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 6 
                 43170522 
                 rs200509434 
                 G 
                 T 
                 CUL9 
                 D 
                 9.13 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.0069 
               
               
                   
               
               
                 4 
                 6 
                 43172581 
                 rs80345623 
                 G 
                 A 
                 CUL9 
                 D 
                 9.13 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.0099 
               
               
                   
               
               
                 4 
                 6 
                 49416648 
                 rs199555550 
                 G 
                 A 
                 MUT 
                 . 
                 13.7 
                 . 
                 156 
                 138 
                 0 
                 3 
                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 6 
                 49425591 
                 rs200908035 
                 T 
                 C 
                 MUT 
                 D 
                 13.7 
                 . 
                 156 
                 138 
                 0 
                 3 
                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 6 
                 49425720 
                 rs528689712 
                 T 
                 C 
                 MUT 
                 D 
                 13.7 
                 . 
                 156 
                 138 
                 0 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 7 
                 100357429 
                 rs374243234 
                 C 
                 T 
                 ZAN 
                 . 
                 3.04 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 7 
                 100363045 
                 rs184742914 
                 A 
                 T 
                 ZAN 
                 . 
                 3.04 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 7 
                 100389715 
                 rs369936309 
                 C 
                 T 
                 ZAN 
                 D 
                 3.04 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 7 
                 128483506 
                 rs200215903 
                 G 
                 A 
                 FLNC 
                 D 
                 2.28 
                 3.39 
                 208 
                 184 
                 1 
                 3 
                 3 
                 0.005 
               
               
                   
               
               
                 4 
                 7 
                 128485314 
                 rs199917473 
                 G 
                 A 
                 FLNC 
                 . 
                 2.28 
                 3.39 
                 208 
                 184 
                 1 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 7 
                 128490926 
                 rs140857707 
                 C 
                 T 
                 FLNC 
                 D 
                 2.28 
                 3.39 
                 208 
                 184 
                 1 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 7 
                 128497224 
                 rs180834558 
                 G 
                 T 
                 FLNC 
                 D 
                 2.28 
                 3.39 
                 208 
                 184 
                 1 
                 3 
                 3 
                 0.0099 
               
               
                   
               
               
                 4 
                 7 
                 149481919 
                 rs561989729 
                 C 
                 G 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.002 
               
               
                   
               
               
                 4 
                 7 
                 149484595 
                 rs532285725 
                 A 
                 G 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.004 
               
               
                   
               
               
                 4 
                 7 
                 149484976 
                 rs372638209 
                 G 
                 A 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.002 
               
               
                   
               
               
                 4 
                 7 
                 149486719 
                 rs185269282 
                 C 
                 G 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.003 
               
               
                   
               
               
                 4 
                 7 
                 149489049 
                 rs189781142 
                 G 
                 T 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.002 
               
               
                   
               
               
                 4 
                 7 
                 149490676 
                 rs4725314 
                 C 
                 T 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.001 
               
               
                   
               
               
                 4 
                 7 
                 149491991 
                 rs550645855 
                 G 
                 A 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.003 
               
               
                   
               
               
                 4 
                 7 
                 149492720 
                 rs573097199 
                 G 
                 A 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.001 
               
               
                   
               
               
                 4 
                 7 
                 149493767 
                 rs118118675 
                 G 
                 A 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.004 
               
               
                   
               
               
                 4 
                 7 
                 149494380 
                 rs376898523 
                 C 
                 T 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.002 
               
               
                   
               
               
                 4 
                 7 
                 149501078 
                 rs147663076 
                 C 
                 A 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.005 
               
               
                   
               
               
                 4 
                 7 
                 149502637 
                 rs375487670 
                 C 
                 T 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.0069 
               
               
                   
               
               
                 4 
                 7 
                 149503944 
                 rs191161538 
                 C 
                 T 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.004 
               
               
                   
               
               
                 4 
                 7 
                 149506195 
                 rs73727627 
                 C 
                 T 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.001 
               
               
                   
               
               
                 4 
                 7 
                 149509035 
                 rs189816441 
                 A 
                 G 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.006 
               
               
                   
               
               
                 4 
                 7 
                 149509064 
                 rs73727632 
                 T 
                 C 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.004 
               
               
                   
               
               
                 4 
                 7 
                 149509079 
                 rs73727633 
                 T 
                 C 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.004 
               
               
                   
               
               
                 4 
                 7 
                 149509381 
                 rs757724 
                 C 
                 T 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.004 
               
               
                   
               
               
                 4 
                 7 
                 149509407 
                 rs146934333 
                 G 
                 C 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.0089 
               
               
                   
               
               
                 4 
                 7 
                 149509691 
                 rs73727635 
                 G 
                 A 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.004 
               
               
                   
               
               
                 4 
                 7 
                 149515870 
                 rs371607382 
                 G 
                 A 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.001 
               
               
                   
               
               
                 4 
                 7 
                 149518144 
                 rs577743302 
                 A 
                 C 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.001 
               
               
                   
               
               
                 4 
                 7 
                 149519649 
                 rs58369703 
                 G 
                 C 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.003 
               
               
                   
               
               
                 4 
                 7 
                 149519705 
                 rs55857423 
                 G 
                 A 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.003 
               
               
                   
               
               
                 4 
                 7 
                 149519711 
                 rs547007891 
                 G 
                 T 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.005 
               
               
                   
               
               
                 4 
                 7 
                 149521545 
                 rs143632762 
                 G 
                 A 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 67246623 
                 rs559974558 
                 G 
                 A 
                 ABCA5 
                 D 
                 2.9 
                 1.5 
                 652 
                 580 
                 6 
                 8 
                 8 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 67247973 
                 rs201343208 
                 G 
                 A 
                 ABCA5 
                 D 
                 2.9 
                 1.5 
                 652 
                 580 
                 6 
                 8 
                 8 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 67250466 
                 rs199641093 
                 C 
                 T 
                 ABCA5 
                 D 
                 2.9 
                 1.5 
                 652 
                 580 
                 6 
                 8 
                 8 
                 0.004 
               
               
                   
               
               
                 4 
                 17 
                 67299017 
                 rs201944918 
                 A 
                 G 
                 ABCA5 
                 D 
                 2.9 
                 1.5 
                 652 
                 580 
                 6 
                 8 
                 8 
                 0.0079 
               
               
                   
               
               
                 4 
                 17 
                 67305519 
                 rs199888749 
                 G 
                 A 
                 ABCA5 
                 D 
                 2.9 
                 1.5 
                 652 
                 580 
                 6 
                 8 
                 8 
                 0.0079 
               
               
                   
               
               
                 4 
                 17 
                 73827216 
                 rs140184929 
                 C 
                 T 
                 UNC13D 
                 D 
                 5.43 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.006 
               
               
                   
               
               
                 4 
                 17 
                 73839609 
                 rs527842266 
                 C 
                 G 
                 UNC13D 
                 . 
                 5.43 
                 . 
                 264 
                 232 
                 0 
                 3 
                 3 
                 0.002 
               
               
                   
               
               
                 4 
                 17 
                 7701543 
                 rs141742705 
                 G 
                 A 
                 DNAH2 
                 D 
                 1.81 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 7705344 
                 rs8073196 
                 G 
                 C 
                 DNAH2 
                 . 
                 1.81 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 7736250 
                 rs201527036 
                 G 
                 A 
                 DNAH2 
                 . 
                 1.81 
                 2.28 
                 396 
                 348 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 79684531 
                 rs201577202 
                 C 
                 T 
                 SLC25A10 
                 . 
                 3.62 
                 1.52 
                 264 
                 232 
                 3 
                 4 
                 4 
                 0.001 
               
               
                   
               
               
                 4 
                 17 
                 79684871 
                 rs77609145 
                 A 
                 T 
                 SLC25A10 
                 D 
                 3.62 
                 1.52 
                 264 
                 232 
                 3 
                 4 
                 4 
                 0.006 
               
               
                   
               
               
                 4 
                 18 
                 2707800 
                 rs184984483 
                 C 
                 T 
                 SMCHD1 
                 . 
                 5.48 
                 3.37 
                 258 
                 230 
                 1 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 18 
                 2777922 
                 rs527648000 
                 C 
                 T 
                 SMCHD1 
                 . 
                 5.48 
                 3.37 
                 258 
                 230 
                 1 
                 3 
                 3 
                 0.005 
               
               
                   
               
               
                 4 
                 18 
                 28911778 
                 rs147775289 
                 T 
                 C 
                 DSG1 
                 D 
                 5.43 
                 1.71 
                 528 
                 464 
                 2 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 18 
                 28934293 
                 rs149191001 
                 C 
                 T 
                 DSG1 
                 D 
                 5.43 
                 1.71 
                 528 
                 464 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 18 
                 28934674 
                 rs181411154 
                 G 
                 A 
                 DSG1 
                 D 
                 5.43 
                 1.71 
                 528 
                 464 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 18 
                 28934927 
                 rs148488583 
                 C 
                 G 
                 DSG1 
                 D 
                 5.43 
                 1.71 
                 528 
                 464 
                 2 
                 3 
                 3 
                 0.004 
               
               
                   
               
               
                 4 
                 18 
                 580853 
                 rs114933134 
                 G 
                 A 
                 CETN1 
                 D 
                 3.62 
                 . 
                 132 
                 116 
                 0 
                 4 
                 4 
                 0.005 
               
               
                   
               
               
                 4 
                 18 
                 61160178 
                 rs370525785 
                 T 
                 C 
                 SERPINB5 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 18 
                 61170818 
                 rs185364126 
                 G 
                 A 
                 SERPINB5 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 18 
                 61305002 
                 rs201297323 
                 T 
                 C 
                 SERPINB4 
                 D 
                 1.81 
                 3.41 
                 264 
                 232 
                 1 
                 3 
                 3 
                 0.0069 
               
               
                   
               
               
                 4 
                 18 
                 61305289 
                 rs188021365 
                 A 
                 T 
                 SERPINB4 
                 . 
                 1.81 
                 3.41 
                 264 
                 232 
                 1 
                 3 
                 3 
                 0.005 
               
               
                   
               
               
                 4 
                 1 
                 87380851 
                 rs546745 
                 A 
                 G 
                 HS2ST1 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.006 
               
               
                   
               
               
                 4 
                 1 
                 87563514 
                 rs143260332 
                 G 
                 A 
                 HS2ST1 
                 . 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 18 
                 76886315 
                 rs200431802 
                 C 
                 T 
                 ATP9B 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 4 
                 18 
                 77096664 
                 rs201172611 
                 G 
                 A 
                 ATP9B 
                 D 
                 3.62 
                 2.28 
                 264 
                 232 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 18 
                 9549345 
                 rs199964908 
                 G 
                 A 
                 PPP4R1 
                 . 
                 2.72 
                 1.71 
                 132 
                 116 
                 2 
                 3 
                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 19 
                 14071095 
                 rs140301367 
                 G 
                 A 
                 DCAF15 
                 . 
                 5.43 
                 3.41 
                 132 
                 116 
                 1 
                 3 
                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 7 
                 149521647 
                 rs564348526 
                 C 
                 T 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.0069 
               
               
                   
               
               
                 4 
                 7 
                 149521654 
                 rs578088844 
                 G 
                 A 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.002 
               
               
                   
               
               
                 4 
                 7 
                 149522951 
                 rs200469643 
                 C 
                 T 
                 SSPO 
                 . 
                 2.79 
                 2.71 
                 1484 
                 1312 
                 5 
                 12 
                 12 
                 0.001 
               
               
                   
               
               
                 4 
                 7 
                 75192236 
                 . 
                 C 
                 A 
                 HIP1 
                 . 
                 4.57 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.0089 
               
               
                   
               
               
                 4 
                 7 
                 75210547 
                 . 
                 A 
                 T 
                 HIP1 
                 . 
                 4.57 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 8 
                 110439252 
                 rs375463553 
                 C 
                 A 
                 PKHD1L1 
                 D 
                 4.57 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.005 
               
               
                   
               
               
                 4 
                 8 
                 110463357 
                 rs202241413 
                 C 
                 T 
                 PKHD1L1 
                 D 
                 4.57 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.003 
               
               
                   
               
               
                 4 
                 8 
                 110493660 
                 rs139600051 
                 A 
                 G 
                 PKHD1L1 
                 . 
                 4.57 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.005 
               
               
                   
               
               
                 4 
                 8 
                 110527435 
                 rs559437602 
                 C 
                 T 
                 PKHD1L1 
                 D 
                 4.57 
                 2.26 
                 208 
                 184 
                 1 
                 2 
                 2 
                 0.002 
               
               
                   
               
               
                 4 
                 8 
                 145736896 
                 rs557256260 
                 C 
                 T 
                 RECQL4 
                 . 
                 2.28 
                 1.7 
                 260 
                 230 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 8 
                 145738985 
                 rs536831548 
                 G 
                 C 
                 RECQL4 
                 . 
                 2.28 
                 1.7 
                 260 
                 230 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 8 
                 145741388 
                 rs200097701 
                 C 
                 G 
                 RECQL4 
                 . 
                 2.28 
                 1.7 
                 260 
                 230 
                 2 
                 3 
                 3 
                 0.005 
               
               
                   
               
               
                 4 
                 8 
                 145741602 
                 rs34633809 
                 C 
                 T 
                 RECQL4 
                 . 
                 2.28 
                 1.7 
                 260 
                 230 
                 2 
                 3 
                 3 
                 0.0089 
               
               
                   
               
               
                 4 
                 8 
                 145742799 
                 rs34642881 
                 T 
                 C 
                 RECQL4 
                 . 
                 2.28 
                 1.7 
                 260 
                 230 
                 2 
                 3 
                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 8 
                 17400906 
                 rs12680645 
                 G 
                 A 
                 SLC7A2 
                 D 
                 3.42 
                 1.7 
                 156 
                 138 
                 2 
                 3 
                 3 
                 0.0079 
               
               
                   
               
               
                 4 
                 8 
                 17407821 
                 rs188973136 
                 C 
                 G 
                 SLC7A2 
                 D 
                 3.42 
                 1.7 
                 156 
                 138 
                 2 
                 3 
                 3 
                 0.006 
               
               
                   
               
               
                 4 
                 8 
                 17417839 
                 rs201373242 
                 A 
                 G 
                 SLC7A2 
                 D 
                 3.42 
                 1.7 
                 156 
                 138 
                 2 
                 3 
                 3 
                 0.001 
               
               
                   
               
               
                 4 
                 9 
                 439392 
                 rs117109271 
                 A 
                 G 
                 DOCK8 
                 . 
                 3.42 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 3 
                 0.0099 
               
               
                   
               
               
                 4 
                 9 
                 441423 
                 rs188141951 
                 C 
                 T 
                 DOCK8 
                 . 
                 3.42 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 3 
                 0.003 
               
               
                   
               
               
                 4 
                 X 
                 1460714 
                 . 
                 C 
                 T 
                 IL3RA 
                 D 
                 9.33 
                 2.31 
                 104 
                 90 
                 1 
                 2 
                 2 
                 0.001 
               
               
                   
               
               
                 4 
                 X 
                 1471130 
                 . 
                 G 
                 T 
                 IL3RA 
                 . 
                 9.33 
                 2.31 
                 104 
                 90 
                 1 
                 2 
                 2 
                 0.004 
               
               
                   
               
               
                 5 
                 2 
                 113342071 
                 rs528909726 
                 G 
                 A 
                 CHCHD5 
                 . 
                 . 
                 . 
                 38 
                 40 
                 0 
                 2 
                 1 
                 0.002 
               
               
                   
               
               
                 5 
                 3 
                 63898360 
                 rs576518931 
                 G 
                 GGCAGCA 
                 ATXN7 
                 . 
                 . 
                 1.76 
                 38 
                 36 
                 3 
                 5 
                 4 
                 0.004 
               
               
                   
               
               
                 5 
                 4 
                 46994972 
                 rs34464680 
                 G 
                 GAA 
                 GABRA4 
                 . 
                 1.41 
                 1.81 
                 70 
                 54 
                 5 
                 7 
                 6 
                 0.0089 
               
               
                   
               
               
                 6 
                 10 
                 122618148 
                 rs2241846 
                 G 
                 C 
                 WDR11 
                 . 
                 1.57 
                 1.67 
                 50 
                 46 
                 15 
                 23 
                 19 
                 0.3472 
               
               
                   
               
               
                 6 
                 10 
                 35485028 
                 rs137918654 
                 G 
                 T 
                 CREM 
                 . 
                 2.74 
                 3.39 
                 52 
                 46 
                 1 
                 3 
                 2 
                 0.0347 
               
               
                   
               
               
                 6 
                 10 
                 44788826 
                 rs58189594 
                 C 
                 T 
                 C10orf142 
                 . 
                 1.87 
                 3.39 
                 52 
                 46 
                 3 
                 9 
                 8 
                 0.1121 
               
               
                   
               
               
                 6 
                 10 
                 47087078 
                 rs2229967 
                 G 
                 T 
                 CH17- 
                 . 
                 1.86 
                 1.83 
                 260 
                 230 
                 13 
                 21 
                 21 
                 . 
               
               
                   
                   
                   
                   
                   
                   
                 360D5.1 
               
               
                   
               
               
                 6 
                 10 
                 47087078 
                 rs2229967 
                 G 
                 T 
                 NPY4R 
                 . 
                 1.86 
                 1.83 
                 260 
                 230 
                 13 
                 21 
                 21 
                 . 
               
               
                   
               
               
                 6 
                 10 
                 47087403 
                 rs781881744 
                 T 
                 C 
                 CH17- 
                 . 
                 1.86 
                 1.83 
                 260 
                 230 
                 13 
                 21 
                 21 
                 . 
               
               
                   
                   
                   
                   
                   
                   
                 360D5.1 
               
               
                   
               
               
                 6 
                 10 
                 47087403 
                 rs781881744 
                 T 
                 C 
                 NPY4R 
                 . 
                 1.86 
                 1.83 
                 260 
                 230 
                 13 
                 21 
                 21 
                 . 
               
               
                   
               
               
                 6 
                 10 
                 47087499 
                 rs114592738 
                 G 
                 A 
                 CH17- 
                 . 
                 1.86 
                 1.83 
                 260 
                 230 
                 13 
                 21 
                 21 
                 . 
               
               
                   
                   
                   
                   
                   
                   
                 360D5.1 
               
               
                   
               
               
                 6 
                 10 
                 47087499 
                 rs114592738 
                 G 
                 A 
                 NPY4R 
                 . 
                 1.86 
                 1.83 
                 260 
                 230 
                 13 
                 21 
                 21 
                 . 
               
               
                   
               
               
                 6 
                 10 
                 47087520 
                 rs115443559 
                 G 
                 A 
                 CH17- 
                 . 
                 1.86 
                 1.83 
                 260 
                 230 
                 13 
                 21 
                 21 
                 0.0179 
               
               
                   
                   
                   
                   
                   
                   
                 360D5.1 
               
               
                   
               
               
                 6 
                 10 
                 47087520 
                 rs115443559 
                 G 
                 A 
                 NPY4R 
                 . 
                 1.86 
                 1.83 
                 260 
                 230 
                 13 
                 21 
                 21 
                 0.0179 
               
               
                   
               
               
                 6 
                 10 
                 47087609 
                 rs79871698 
                 G 
                 A 
                 CH17- 
                 . 
                 1.86 
                 1.83 
                 260 
                 230 
                 13 
                 21 
                 21 
                 0.0923 
               
               
                   
                   
                   
                   
                   
                   
                 360D5.1 
               
               
                   
               
               
                 6 
                 10 
                 47087609 
                 rs79871698 
                 G 
                 A 
                 NPY4R 
                 . 
                 1.86 
                 1.83 
                 260 
                 230 
                 13 
                 21 
                 21 
                 0.0923 
               
               
                   
               
               
                 6 
                 10 
                 7747155 
                 rs76983422 
                 G 
                 C 
                 ITIH2 
                 . 
                 2.74 
                 1.7 
                 52 
                 46 
                 2 
                 3 
                 3 
                 0.0397 
               
               
                   
               
               
                 6 
                 1 
                 100617938 
                 rs78161968 
                 T 
                 C 
                 LRRC39 
                 . 
                 1.68 
                 2.29 
                 156 
                 136 
                 3 
                 6 
                 6 
                 0.0446 
               
               
                   
               
               
                 6 
                 1 
                 100618085 
                 rs773979041 
                 A 
                 G 
                 LRRC39 
                 . 
                 1.68 
                 2.29 
                 156 
                 136 
                 3 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 100620728 
                 rs78962557 
                 G 
                 A 
                 LRRC39 
                 . 
                 1.68 
                 2.29 
                 156 
                 136 
                 3 
                 6 
                 6 
                 0.0198 
               
               
                   
               
               
                 6 
                 1 
                 109456983 
                 rs141562079 
                 C 
                 T 
                 GPSM2 
                 D 
                 2.28 
                 6.78 
                 156 
                 138 
                 1 
                 6 
                 6 
                 0.0258 
               
               
                   
               
               
                 6 
                 1 
                 109465156 
                 rs199964596 
                 TCAA 
                 T 
                 GPSM2 
                 . 
                 2.28 
                 6.78 
                 156 
                 138 
                 1 
                 6 
                 6 
                 0.0129 
               
               
                   
               
               
                 6 
                 1 
                 109465165 
                 rs35029887 
                 ACTT 
                 A 
                 GPSM2 
                 . 
                 2.28 
                 6.78 
                 156 
                 138 
                 1 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 11 
                 118886656 
                 rs7131534 
                 G 
                 A 
                 RPS25 
                 . 
                 1.52 
                 1.7 
                 52 
                 46 
                 2 
                 3 
                 3 
                 0.0704 
               
               
                   
               
               
                 6 
                 11 
                 13410690 
                 rs375824034 
                 TGAAA 
                 T 
                 BTBD10 
                 . 
                 2.49 
                 1.7 
                 52 
                 46 
                 4 
                 6 
                 6 
                 0.0675 
               
               
                   
               
               
                 6 
                 11 
                 16812551 
                 rs116885602 
                 C 
                 T 
                 PLEKHA7 
                 . 
                 1.61 
                 1.85 
                 100 
                 90 
                 6 
                 10 
                 9 
                 0.0456 
               
               
                   
               
               
                 6 
                 11 
                 16863087 
                 rs452745 
                 A 
                 G 
                 PLEKHA7 
                 . 
                 1.61 
                 1.85 
                 100 
                 90 
                 6 
                 10 
                 9 
                 0.1617 
               
               
                   
               
               
                 6 
                 1 
                 118530450 
                 rs184368389 
                 T 
                 C 
                 SPAG17 
                 . 
                 4.57 
                 3.39 
                 52 
                 46 
                 1 
                 3 
                 3 
                 0.0179 
               
               
                   
               
               
                 6 
                 1 
                 12082881 
                 rs11588779 
                 C 
                 T 
                 MIIP 
                 . 
                 4.57 
                 3.39 
                 52 
                 46 
                 2 
                 6 
                 6 
                 0.0685 
               
               
                   
               
               
                 6 
                 11 
                 22232870 
                 rs78987921 
                 G 
                 A 
                 ANO5 
                 . 
                 4.57 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.0109 
               
               
                   
               
               
                 6 
                 11 
                 22239801 
                 . 
                 C 
                 T 
                 ANO5 
                 . 
                 4.57 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 11 
                 32636495 
                 rs145888197 
                 T 
                 C 
                 CCDC73 
                 . 
                 1.52 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0377 
               
               
                   
               
               
                 6 
                 1 
                 145414790 
                 . 
                 G 
                 C 
                 HFE2 
                 . 
                 4.57 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0129 
               
               
                   
               
               
                 6 
                 1 
                 145456731 
                 rs6694055 
                 G 
                 C 
                 POLR3GL 
                 . 
                 1.83 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0119 
               
               
                   
               
               
                 6 
                 1 
                 145527604 
                 rs2274620 
                 A 
                 G 
                 ITGA10 
                 . 
                 1.62 
                 2.94 
                 260 
                 230 
                 5 
                 13 
                 12 
                 0.0208 
               
               
                   
               
               
                 6 
                 1 
                 145534221 
                 . 
                 G 
                 T 
                 ITGA10 
                 . 
                 1.62 
                 2.94 
                 260 
                 230 
                 5 
                 13 
                 12 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 145536082 
                 rs2274616 
                 G 
                 A 
                 ITGA10 
                 . 
                 1.62 
                 2.94 
                 260 
                 230 
                 5 
                 13 
                 12 
                 0.0704 
               
               
                   
               
               
                 6 
                 1 
                 145541806 
                 rs77912414 
                 T 
                 C 
                 ITGA10 
                 . 
                 1.62 
                 2.94 
                 260 
                 230 
                 5 
                 13 
                 12 
                 0.0119 
               
               
                   
               
               
                 6 
                 1 
                 152484245 
                 rs2282298 
                 C 
                 T 
                 LCE5A 
                 . 
                 2.28 
                 3.39 
                 52 
                 46 
                 1 
                 3 
                 3 
                 0.0228 
               
               
                   
               
               
                 6 
                 11 
                 55136125 
                 rs117954374 
                 C 
                 T 
                 OR4A15 
                 . 
                 2.08 
                 2.83 
                 52 
                 46 
                 2 
                 5 
                 5 
                 0.0585 
               
               
                   
               
               
                 6 
                 11 
                 551644 
                 rs113026126 
                 C 
                 T 
                 LRRC56 
                 . 
                 2.54 
                 1.88 
                 52 
                 46 
                 3 
                 5 
                 5 
                 0.0476 
               
               
                   
               
               
                 6 
                 11 
                 5776484 
                 rs4910844 
                 A 
                 T 
                 OR52N4 
                 . 
                 1.56 
                 2.64 
                 52 
                 46 
                 6 
                 14 
                 10 
                 0.1974 
               
               
                   
               
               
                 6 
                 1 
                 15834360 
                 rs2020902 
                 A 
                 G 
                 CASP9 
                 . 
                 3.04 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0317 
               
               
                   
               
               
                 6 
                 1 
                 15860803 
                 rs11583306 
                 C 
                 T 
                 DNAJC16 
                 . 
                 2.74 
                 1.7 
                 52 
                 46 
                 2 
                 3 
                 3 
                 0.0466 
               
               
                   
               
               
                 6 
                 1 
                 159799808 
                 rs10430458 
                 C 
                 T 
                 SLAMF8 
                 . 
                 3.42 
                 1.7 
                 52 
                 46 
                 2 
                 3 
                 3 
                 0.0317 
               
               
                   
               
               
                 6 
                 1 
                 159858290 
                 rs3795334 
                 T 
                 A 
                 CFAP45 
                 . 
                 1.52 
                 2.83 
                 52 
                 46 
                 2 
                 5 
                 5 
                 0.0556 
               
               
                   
               
               
                 6 
                 11 
                 61048196 
                 rs78505441 
                 G 
                 C 
                 VWCE 
                 . 
                 1.83 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0268 
               
               
                   
               
               
                 6 
                 11 
                 61071331 
                 rs28720346 
                 C 
                 T 
                 DDB1 
                 . 
                 1.83 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0258 
               
               
                   
               
               
                 6 
                 11 
                 62365619 
                 rs11231155 
                 A 
                 G 
                 MTA2 
                 . 
                 1.83 
                 2.26 
                 52 
                 46 
                 2 
                 4 
                 4 
                 0.0526 
               
               
                   
               
               
                 6 
                 11 
                 62369881 
                 rs35156678 
                 G 
                 A 
                 EML3 
                 . 
                 2.03 
                 2.26 
                 52 
                 46 
                 2 
                 4 
                 4 
                 0.0437 
               
               
                   
               
               
                 6 
                 1 
                 16382911 
                 rs72474563 
                 A 
                 G 
                 CLCNKB 
                 . 
                 9.13 
                 2.26 
                 52 
                 46 
                 2 
                 4 
                 4 
                 0.0357 
               
               
                   
               
               
                 6 
                 11 
                 67771408 
                 rs188940236 
                 C 
                 T 
                 UNC93B1 
                 . 
                 1.62 
                 2.2 
                 44 
                 40 
                 2 
                 4 
                 4 
                 0.0308 
               
               
                   
               
               
                 6 
                 1 
                 168105581 
                 rs200664972 
                 A 
                 AG 
                 GPR161 
                 . 
                 1.83 
                 4.52 
                 52 
                 46 
                 1 
                 4 
                 4 
                 0.0516 
               
               
                   
               
               
                 6 
                 11 
                 71710425 
                 rs373342292 
                 CTCA 
                 C 
                 IL18BP 
                 . 
                 3.65 
                 . 
                 52 
                 46 
                 0 
                 4 
                 4 
                 0.0198 
               
               
                   
               
               
                 6 
                 1 
                 177247693 
                 rs138799872 
                 C 
                 T 
                 BRINP2 
                 . 
                 4.57 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0119 
               
               
                   
               
               
                 6 
                 11 
                 797714 
                 . 
                 T 
                 A 
                 PANO1 
                 . 
                 7.72 
                 2.83 
                 154 
                 136 
                 2 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 11 
                 798082 
                 rs201547522 
                 C 
                 CT 
                 PANO1 
                 . 
                 7.72 
                 2.83 
                 154 
                 136 
                 2 
                 5 
                 5 
                 0.0248 
               
               
                   
               
               
                 6 
                 11 
                 798222 
                 rs572464433 
                 T 
                 TCGC 
                 PANO1 
                 . 
                 7.72 
                 2.83 
                 154 
                 136 
                 2 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 180240510 
                 rs2764449 
                 T 
                 C 
                 LHX4 
                 . 
                 2.28 
                 . 
                 156 
                 138 
                 0 
                 3 
                 3 
                 0.0139 
               
               
                   
               
               
                 6 
                 1 
                 180243593 
                 rs200119009 
                 C 
                 T 
                 LHX4 
                 D 
                 2.28 
                 . 
                 156 
                 138 
                 0 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 180243601 
                 . 
                 G 
                 A 
                 LHX4 
                 D 
                 2.28 
                 . 
                 156 
                 138 
                 0 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 201356001 
                 . 
                 CCCA 
                 * 
                 LAD1 
                 . 
                 4.38 
                 1.92 
                 184 
                 160 
                 12 
                 20 
                 20 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 201356001 
                 rs398053706 
                 CCCA 
                 C 
                 LAD1 
                 . 
                 4.38 
                 1.92 
                 184 
                 160 
                 12 
                 20 
                 20 
                 0.0575 
               
               
                   
               
               
                 6 
                 1 
                 201356004 
                 . 
                 ACC 
                 * 
                 LAD1 
                 . 
                 4.38 
                 1.92 
                 184 
                 160 
                 12 
                 20 
                 20 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 201356004 
                 rs552300739 
                 ACC 
                 A 
                 LAD1 
                 . 
                 4.38 
                 1.92 
                 184 
                 160 
                 12 
                 20 
                 20 
                 0.0486 
               
               
                   
               
               
                 6 
                 1 
                 210267893 
                 rs144713062 
                 TGAA 
                 T 
                 SYT14 
                 . 
                 3.2 
                 3.96 
                 52 
                 46 
                 2 
                 7 
                 6 
                 0.0655 
               
               
                   
               
               
                 6 
                 12 
                 110923012 
                 rs142702785 
                 A 
                 G 
                 FAM216A 
                 . 
                 2.74 
                 . 
                 52 
                 46 
                 0 
                 3 
                 3 
                 0.0149 
               
               
                   
               
               
                 6 
                 12 
                 113592306 
                 rs200344876 
                 G 
                 GC 
                 CFAP73 
                 . 
                 3.42 
                 3.39 
                 52 
                 46 
                 1 
                 3 
                 3 
                 0.0169 
               
               
                   
               
               
                 6 
                 1 
                 2117557 
                 rs547643542 
                 G 
                 A 
                 FAAP20 
                 . 
                 3.65 
                 1.51 
                 104 
                 92 
                 6 
                 8 
                 7 
                 0.0139 
               
               
                   
               
               
                 6 
                 12 
                 122243731 
                 rs557334621 
                 C 
                 T 
                 SETD1B 
                 . 
                 2.28 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 12 
                 122255354 
                 rs541427059 
                 TGCG 
                 T 
                 SETD1B 
                 . 
                 2.28 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.0129 
               
               
                   
               
               
                 6 
                 12 
                 122265770 
                 rs117774166 
                 G 
                 A 
                 SETD1B 
                 . 
                 2.28 
                 2.26 
                 156 
                 138 
                 1 
                 2 
                 2 
                 0.0188 
               
               
                   
               
               
                 6 
                 12 
                 12630665 
                 rs142947418 
                 TGCACGCTGG 
                 T 
                 DUSP16 
                 . 
                 1.55 
                 1.64 
                 178 
                 154 
                 48 
                 68 
                 57 
                 0.13 
               
               
                   
                   
                   
                   
                 (SEQ ID 
               
               
                   
                   
                   
                   
                 NO: 10) 
               
               
                   
               
               
                 6 
                 12 
                 12630675 
                 rs201941751 
                 GCACGC 
                 G 
                 DUSP16 
                 . 
                 1.55 
                 1.64 
                 178 
                 154 
                 48 
                 68 
                 57 
                 0.2698 
               
               
                   
               
               
                 6 
                 12 
                 12630681 
                 rs200271649 
                 TGGGC 
                 T 
                 DUSP16 
                 . 
                 1.55 
                 1.64 
                 178 
                 154 
                 48 
                 68 
                 57 
                 0.2698 
               
               
                   
               
               
                 6 
                 12 
                 12633287 
                 rs10845555 
                 A 
                 G 
                 DUSP16 
                 . 
                 1.55 
                 1.64 
                 178 
                 154 
                 48 
                 68 
                 57 
                 0.4097 
               
               
                   
               
               
                 6 
                 1 
                 2130262 
                 rs144802031 
                 C 
                 G 
                 FAAP20 
                 . 
                 3.65 
                 1.51 
                 104 
                 92 
                 6 
                 8 
                 7 
                 0.0754 
               
               
                   
               
               
                 6 
                 12 
                 14923935 
                 rs199781231 
                 T 
                 TC 
                 HIST4H4 
                 . 
                 1.52 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0198 
               
               
                   
               
               
                 6 
                 12 
                 16377347 
                 rs117974895 
                 C 
                 T 
                 SLC15A5 
                 . 
                 2.28 
                 1.7 
                 52 
                 46 
                 2 
                 3 
                 3 
                 0.0337 
               
               
                   
               
               
                 6 
                 1 
                 224008913 
                 rs3738370 
                 G 
                 A 
                 TP53BP2 
                 . 
                 1.89 
                 1.51 
                 52 
                 46 
                 9 
                 12 
                 11 
                 0.1925 
               
               
                   
               
               
                 6 
                 1 
                 228289872 
                 rs373634959 
                 G 
                 A 
                 C1orf35 
                 . 
                 2.28 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0139 
               
               
                   
               
               
                 6 
                 1 
                 22924364 
                 rs72651347 
                 G 
                 A 
                 EPHA8 
                 . 
                 2.28 
                 1.7 
                 104 
                 92 
                 2 
                 3 
                 3 
                 0.0179 
               
               
                   
               
               
                 6 
                 1 
                 22927298 
                 rs569320402 
                 C 
                 T 
                 EPHA8 
                 D 
                 2.28 
                 1.7 
                 104 
                 92 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 234509972 
                 rs73099933 
                 A 
                 G 
                 COA6 
                 . 
                 2.5 
                 2.89 
                 52 
                 42 
                 3 
                 7 
                 7 
                 0.0804 
               
               
                   
               
               
                 6 
                 1 
                 247719769 
                 rs56043070 
                 G 
                 A 
                 GCSAML 
                 . 
                 2.28 
                 3.39 
                 52 
                 46 
                 1 
                 3 
                 3 
                 0.0327 
               
               
                   
               
               
                 6 
                 1 
                 248512939 
                 rs201185608 
                 AC 
                 A 
                 OR14C36 
                 . 
                 1.76 
                 1.88 
                 52 
                 46 
                 3 
                 5 
                 5 
                 0.0615 
               
               
                   
               
               
                 6 
                 12 
                 49721122 
                 rs73309977 
                 C 
                 T 
                 TROAP 
                 . 
                 1.96 
                 3.39 
                 52 
                 46 
                 1 
                 3 
                 3 
                 0.0397 
               
               
                   
               
               
                 6 
                 12 
                 51510213 
                 rs77417603 
                 T 
                 A 
                 TFCP2 
                 . 
                 2.28 
                 2.26 
                 52 
                 46 
                 2 
                 4 
                 4 
                 0.0228 
               
               
                   
               
               
                 6 
                 12 
                 52156281 
                 rs187002252 
                 A 
                 G 
                 SCN8A 
                 . 
                 1.83 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0179 
               
               
                   
               
               
                 6 
                 12 
                 53427826 
                 rs140133257 
                 G 
                 T 
                 EIF4B 
                 . 
                 2.74 
                 . 
                 52 
                 46 
                 0 
                 3 
                 3 
                 0.0228 
               
               
                   
               
               
                 6 
                 12 
                 54756528 
                 rs77759698 
                 A 
                 G 
                 GPR84 
                 D 
                 1.76 
                 5.65 
                 52 
                 46 
                 1 
                 5 
                 5 
                 0.0347 
               
               
                   
               
               
                 6 
                 12 
                 55523586 
                 rs398102299 
                 AT 
                 A 
                 OR9K2 
                 . 
                 1.66 
                 3.01 
                 52 
                 46 
                 3 
                 8 
                 7 
                 0.1141 
               
               
                   
               
               
                 6 
                 12 
                 55641255 
                 rs4522268 
                 C 
                 T 
                 OR6C74 
                 . 
                 1.96 
                 3.39 
                 52 
                 46 
                 3 
                 9 
                 8 
                 0.1171 
               
               
                   
               
               
                 6 
                 12 
                 55759191 
                 rs398102300 
                 AT 
                 A 
                 OR6C75 
                 . 
                 2.28 
                 3.96 
                 52 
                 46 
                 2 
                 7 
                 7 
                 0.0724 
               
               
                   
               
               
                 6 
                 12 
                 58007149 
                 rs141337782 
                 G 
                 C 
                 ARHGEF25 
                 . 
                 1.52 
                 2.83 
                 52 
                 46 
                 2 
                 5 
                 4 
                 0.1151 
               
               
                   
               
               
                 6 
                 1 
                 26524503 
                 rs199601379 
                 C 
                 T 
                 CATSPER4 
                 D 
                 1.71 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 26526554 
                 rs6700024 
                 G 
                 A 
                 CATSPER4 
                 . 
                 1.71 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 2 
                 0.0208 
               
               
                   
               
               
                 6 
                 12 
                 70928745 
                 rs3752702 
                 G 
                 A 
                 PTPRB 
                 . 
                 3.04 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0486 
               
               
                   
               
               
                 6 
                 12 
                 95456367 
                 rs138805411 
                 T 
                 C 
                 NR2C1 
                 D 
                 4.57 
                 4.52 
                 52 
                 46 
                 1 
                 4 
                 4 
                 0.0208 
               
               
                   
               
               
                 6 
                 13 
                 76457183 
                 rs9530477 
                 T 
                 C 
                 LMO7DN 
                 . 
                 1.66 
                 1.88 
                 52 
                 46 
                 12 
                 20 
                 15 
                 0.3284 
               
               
                   
               
               
                 6 
                 14 
                 35182348 
                 rs35515423 
                 GA 
                 G 
                 CFL2 
                 . 
                 1.55 
                 1.7 
                 46 
                 44 
                 8 
                 13 
                 11 
                 0.2034 
               
               
                   
               
               
                 6 
                 14 
                 94750501 
                 rs77844573 
                 A 
                 G 
                 SERPINA10 
                 . 
                 1.6 
                 1.98 
                 104 
                 92 
                 4 
                 7 
                 7 
                 0.0258 
               
               
                   
               
               
                 6 
                 14 
                 94756458 
                 rs2232699 
                 A 
                 T 
                 SERPINA10 
                 D 
                 1.6 
                 1.98 
                 104 
                 92 
                 4 
                 7 
                 7 
                 0.0298 
               
               
                   
               
               
                 6 
                 15 
                 101013123 
                 rs1566775 
                 G 
                 A 
                 CERS3 
                 . 
                 4.57 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0258 
               
               
                   
               
               
                 6 
                 15 
                 101601367 
                 rs148929418 
                 C 
                 CACTT 
                 LRRK1 
                 . 
                 3.26 
                 2.26 
                 52 
                 46 
                 5 
                 10 
                 10 
                 0.1409 
               
               
                   
               
               
                 6 
                 15 
                 28947605 
                 rs3893142 
                 C 
                 A 
                 GOLGA8M 
                 . 
                 1.75 
                 1.53 
                 46 
                 40 
                 3 
                 4 
                 4 
                 0.0675 
               
               
                   
               
               
                 6 
                 15 
                 60803458 
                 rs779626945 
                 C 
                 T 
                 RORA 
                 D 
                 2.28 
                 . 
                 104 
                 92 
                 0 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 15 
                 60919432 
                 rs73424068 
                 C 
                 T 
                 RORA 
                 . 
                 2.28 
                 . 
                 104 
                 92 
                 0 
                 3 
                 3 
                 0.0149 
               
               
                   
               
               
                 6 
                 15 
                 78458485 
                 rs3816253 
                 T 
                 C 
                 IDH3A 
                 . 
                 1.64 
                 1.58 
                 52 
                 46 
                 10 
                 14 
                 11 
                 0.1885 
               
               
                   
               
               
                 6 
                 16 
                 1272750 
                 rs113856625 
                 G 
                 A 
                 TPSG1 
                 D 
                 2.13 
                 3.96 
                 104 
                 92 
                 2 
                 7 
                 7 
                 . 
               
               
                   
               
               
                 6 
                 16 
                 1273444 
                 rs61587627 
                 G 
                 T 
                 TPSG1 
                 D 
                 2.13 
                 3.96 
                 104 
                 92 
                 2 
                 7 
                 7 
                 0.0972 
               
               
                   
               
               
                 6 
                 16 
                 13297242 
                 rs13331224 
                 C 
                 T 
                 SHISA9 
                 . 
                 1.64 
                 1.57 
                 48 
                 46 
                 6 
                 9 
                 9 
                 0.1042 
               
               
                   
               
               
                 6 
                 16 
                 1825689 
                 rs3826055 
                 C 
                 T 
                 EME2 
                 . 
                 6.85 
                 1.7 
                 104 
                 92 
                 2 
                 3 
                 3 
                 0.0129 
               
               
                   
               
               
                 6 
                 16 
                 1825789 
                 rs746707908 
                 T 
                 C 
                 EME2 
                 . 
                 6.85 
                 1.7 
                 104 
                 92 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 1 
                 6266793 
                 rs72853039 
                 G 
                 C 
                 RNF207 
                 . 
                 1.71 
                 3.39 
                 52 
                 46 
                 2 
                 6 
                 6 
                 0.0972 
               
               
                   
               
               
                 6 
                 16 
                 28998111 
                 rs4788115 
                 T 
                 A 
                 LAT 
                 . 
                 1.74 
                 2.26 
                 52 
                 46 
                 4 
                 8 
                 8 
                 0.1359 
               
               
                   
               
               
                 6 
                 16 
                 30455945 
                 rs146596728 
                 A 
                 C 
                 SEPHS2 
                 . 
                 4.57 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.0248 
               
               
                   
               
               
                 6 
                 16 
                 30456188 
                 rs550048089 
                 G 
                 A 
                 SEPHS2 
                 . 
                 4.57 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 16 
                 3075701 
                 rs2717664 
                 C 
                 T 
                 THOC6 
                 . 
                 1.72 
                 2.75 
                 104 
                 92 
                 14 
                 34 
                 28 
                 0.1825 
               
               
                   
               
               
                 6 
                 16 
                 3075999 
                 rs2245000 
                 C 
                 G 
                 THOC6 
                 . 
                 1.72 
                 2.75 
                 104 
                 92 
                 14 
                 34 
                 28 
                 0.3046 
               
               
                   
               
               
                 6 
                 16 
                 3554840 
                 rs80187466 
                 G 
                 T 
                 CLUAP1 
                 . 
                 1.96 
                 . 
                 156 
                 138 
                 0 
                 9 
                 9 
                 0.0556 
               
               
                   
               
               
                 6 
                 16 
                 3558283 
                 rs59492947 
                 A 
                 T 
                 CLUAP1 
                 . 
                 1.96 
                 . 
                 156 
                 138 
                 0 
                 9 
                 9 
                 0.0556 
               
               
                   
               
               
                 6 
                 16 
                 3580565 
                 rs79684678 
                 T 
                 C 
                 CLUAP1 
                 . 
                 1.96 
                 . 
                 156 
                 138 
                 0 
                 9 
                 9 
                 0.0556 
               
               
                   
               
               
                 6 
                 16 
                 5077897 
                 rs112669475 
                 G 
                 A 
                 NAGPA 
                 . 
                 2.03 
                 . 
                 52 
                 46 
                 0 
                 4 
                 4 
                 0.0397 
               
               
                   
               
               
                 6 
                 16 
                 57736047 
                 rs72795521 
                 G 
                 A 
                 DRC7 
                 . 
                 1.71 
                 1.7 
                 156 
                 138 
                 14 
                 21 
                 17 
                 0.2669 
               
               
                   
               
               
                 6 
                 16 
                 57756907 
                 rs113469607 
                 C 
                 A 
                 DRC7 
                 . 
                 1.71 
                 1.7 
                 156 
                 138 
                 14 
                 21 
                 17 
                 0.0218 
               
               
                   
               
               
                 6 
                 16 
                 57757046 
                 rs139945134 
                 C 
                 T 
                 DRC7 
                 . 
                 1.71 
                 1.7 
                 156 
                 138 
                 14 
                 21 
                 17 
                 0.0129 
               
               
                   
               
               
                 6 
                 1 
                 6647702 
                 rs183072854 
                 G 
                 A 
                 ZBTB48 
                 . 
                 3.04 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0268 
               
               
                   
               
               
                 6 
                 16 
                 67180171 
                 rs7184692 
                 T 
                 C 
                 C16orf70 
                 . 
                 2.54 
                 2.83 
                 52 
                 46 
                 2 
                 5 
                 5 
                 0.0595 
               
               
                   
               
               
                 6 
                 16 
                 83998662 
                 rs733728 
                 A 
                 G 
                 OSGIN1 
                 . 
                 1.68 
                 . 
                 52 
                 46 
                 0 
                 7 
                 7 
                 0.0962 
               
               
                   
               
               
                 6 
                 16 
                 84801966 
                 rs189466547 
                 T 
                 C 
                 USP10 
                 . 
                 4.57 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0109 
               
               
                   
               
               
                 6 
                 17 
                 27067480 
                 rs750108245 
                 G 
                 A 
                 NEK8 
                 . 
                 1.9 
                 2.83 
                 208 
                 184 
                 2 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 27067558 
                 rs565763400 
                 C 
                 T 
                 NEK8 
                 . 
                 1.9 
                 2.83 
                 208 
                 184 
                 2 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 27068005 
                 rs147832976 
                 TGAG 
                 T 
                 NEK8 
                 . 
                 1.9 
                 2.83 
                 208 
                 184 
                 2 
                 5 
                 5 
                 0.0407 
               
               
                   
               
               
                 6 
                 17 
                 27068012 
                 rs757972103 
                 G 
                 T 
                 NEK8 
                 . 
                 1.9 
                 2.83 
                 208 
                 184 
                 2 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 34182099 
                 rs149317141 
                 G 
                 GT 
                 HEATR9 
                 . 
                 1.56 
                 1.7 
                 156 
                 138 
                 20 
                 30 
                 27 
                 0.0198 
               
               
                   
               
               
                 6 
                 17 
                 34185535 
                 rs35283303 
                 AG 
                 A 
                 HEATR9 
                 . 
                 1.56 
                 1.7 
                 156 
                 138 
                 20 
                 30 
                 27 
                 0.3224 
               
               
                   
               
               
                 6 
                 17 
                 34192406 
                 . 
                 G 
                 A 
                 HEATR9 
                 . 
                 1.56 
                 1.7 
                 156 
                 138 
                 20 
                 30 
                 27 
                 0.0952 
               
               
                   
               
               
                 6 
                 17 
                 36895514 
                 rs72819704 
                 A 
                 G 
                 PCGF2 
                 . 
                 1.63 
                 1.88 
                 104 
                 92 
                 6 
                 10 
                 9 
                 0.0169 
               
               
                   
               
               
                 6 
                 17 
                 36896534 
                 rs2075057 
                 C 
                 T 
                 PCGF2 
                 . 
                 1.63 
                 1.88 
                 104 
                 92 
                 6 
                 10 
                 9 
                 0.0962 
               
               
                   
               
               
                 6 
                 17 
                 37824838 
                 . 
                 GCAA 
                 G 
                 PNMT 
                 . 
                 2.28 
                 4.52 
                 104 
                 92 
                 1 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 37826201 
                 rs60871117 
                 C 
                 T 
                 PNMT 
                 . 
                 2.28 
                 4.52 
                 104 
                 92 
                 1 
                 4 
                 4 
                 0.0357 
               
               
                   
               
               
                 6 
                 17 
                 48753044 
                 rs371874263 
                 C 
                 T 
                 ABCC3 
                 D 
                 2.28 
                 1.51 
                 208 
                 184 
                 3 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 48755450 
                 rs11568583 
                 A 
                 G 
                 ABCC3 
                 . 
                 2.28 
                 1.51 
                 208 
                 184 
                 3 
                 4 
                 4 
                 0.0258 
               
               
                   
               
               
                 6 
                 17 
                 48761020 
                 rs572541933 
                 G 
                 A 
                 ABCC3 
                 D 
                 2.28 
                 1.51 
                 208 
                 184 
                 3 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 48765100 
                 rs756871504 
                 C 
                 T 
                 ABCC3 
                 . 
                 2.28 
                 1.51 
                 208 
                 184 
                 3 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 4906146 
                 rs10533622 
                 GC 
                 G 
                 KIF1C 
                 . 
                 1.7 
                 1.75 
                 164 
                 194 
                 30 
                 62 
                 53 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 4906146 
                 rs146311497 
                 GCC 
                 G 
                 KIF1C 
                 . 
                 1.7 
                 1.75 
                 164 
                 194 
                 30 
                 62 
                 53 
                 0.3244 
               
               
                   
               
               
                 6 
                 17 
                 4906146 
                 rs763524690 
                 G 
                 GC 
                 KIF1C 
                 . 
                 1.7 
                 1.75 
                 164 
                 194 
                 30 
                 62 
                 53 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 4907374 
                 rs766141834 
                 G 
                 A 
                 KIF1C 
                 . 
                 1.7 
                 1.75 
                 164 
                 194 
                 30 
                 62 
                 53 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 4924097 
                 rs4790725 
                 C 
                 G 
                 KIF1C 
                 . 
                 1.7 
                 1.75 
                 164 
                 194 
                 30 
                 62 
                 53 
                 0.0446 
               
               
                   
               
               
                 6 
                 17 
                 59667953 
                 rs17610181 
                 G 
                 A 
                 NACA2 
                 . 
                 1.77 
                 1.94 
                 52 
                 46 
                 7 
                 12 
                 11 
                 0.1667 
               
               
                   
               
               
                 6 
                 17 
                 64876769 
                 rs376464596 
                 C 
                 T 
                 CACNG5 
                 D 
                 2.09 
                 1.55 
                 156 
                 138 
                 8 
                 11 
                 9 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 64876770 
                 rs142916987 
                 G 
                 A 
                 CACNG5 
                 D 
                 2.09 
                 1.55 
                 156 
                 138 
                 8 
                 11 
                 9 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 64880788 
                 rs2286677 
                 G 
                 A 
                 CACNG5 
                 . 
                 2.09 
                 1.55 
                 156 
                 138 
                 8 
                 11 
                 9 
                 0.126 
               
               
                   
               
               
                 6 
                 17 
                 76130947 
                 rs62079073 
                 G 
                 T 
                 TMC8 
                 . 
                 1.52 
                 1.58 
                 52 
                 46 
                 5 
                 7 
                 7 
                 0.0804 
               
               
                   
               
               
                 6 
                 17 
                 8109965 
                 rs144397670 
                 G 
                 A 
                 AURKB 
                 . 
                 1.71 
                 3.36 
                 206 
                 184 
                 1 
                 3 
                 3 
                 0.0159 
               
               
                   
               
               
                 6 
                 17 
                 8110079 
                 rs139322514 
                 G 
                 A 
                 AURKB 
                 . 
                 1.71 
                 3.36 
                 206 
                 184 
                 1 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 8113270 
                 rs766965552 
                 A 
                 G 
                 AURKB 
                 . 
                 1.71 
                 3.36 
                 206 
                 184 
                 1 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 17 
                 8113544 
                 . 
                 C 
                 G 
                 AURKB 
                 . 
                 1.71 
                 3.36 
                 206 
                 184 
                 1 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 18 
                 33694444 
                 rs148550301 
                 A 
                 G 
                 SLC39A6 
                 . 
                 4.57 
                 . 
                 52 
                 46 
                 0 
                 3 
                 3 
                 0.0298 
               
               
                   
               
               
                 6 
                 1 
                 89523927 
                 rs60070945 
                 C 
                 T 
                 GBP1 
                 . 
                 1.71 
                 2.03 
                 52 
                 46 
                 5 
                 9 
                 9 
                 0.12 
               
               
                   
               
               
                 6 
                 19 
                 10426524 
                 rs79442975 
                 G 
                 A 
                 FDX1L 
                 . 
                 1.83 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0397 
               
               
                   
               
               
                 6 
                 19 
                 12875807 
                 rs115585485 
                 A 
                 C 
                 HOOK2 
                 . 
                 1.96 
                 3.39 
                 52 
                 46 
                 1 
                 3 
                 3 
                 0.0238 
               
               
                   
               
               
                 6 
                 19 
                 1917687 
                 rs138069352 
                 C 
                 G 
                 SCAMP4 
                 . 
                 1.71 
                 3.39 
                 52 
                 46 
                 1 
                 3 
                 3 
                 0.0437 
               
               
                   
               
               
                 6 
                 1 
                 92798945 
                 rs78196083 
                 C 
                 T 
                 RPAP2 
                 . 
                 1.52 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0456 
               
               
                   
               
               
                 6 
                 19 
                 32083223 
                 rs11880125 
                 A 
                 G 
                 THEG5 
                 . 
                 4.57 
                 1.7 
                 104 
                 92 
                 4 
                 6 
                 6 
                 0.0179 
               
               
                   
               
               
                 6 
                 19 
                 32083250 
                 rs79323410 
                 T 
                 C 
                 THEG5 
                 . 
                 4.57 
                 1.7 
                 104 
                 92 
                 4 
                 6 
                 6 
                 0.0179 
               
               
                   
               
               
                 6 
                 19 
                 39905903 
                 rs3859551 
                 A 
                 G 
                 PLEKHG2 
                 . 
                 1.64 
                 1.7 
                 260 
                 230 
                 4 
                 6 
                 6 
                 0.0387 
               
               
                   
               
               
                 6 
                 19 
                 39906985 
                 rs10401595 
                 T 
                 C 
                 PLEKHG2 
                 . 
                 1.64 
                 1.7 
                 260 
                 230 
                 4 
                 6 
                 6 
                 0.0387 
               
               
                   
               
               
                 6 
                 19 
                 39907573 
                 rs763779951 
                 C 
                 G 
                 PLEKHG2 
                 D 
                 1.64 
                 1.7 
                 260 
                 230 
                 4 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 39915627 
                 rs200639701 
                 A 
                 G 
                 PLEKHG2 
                 D 
                 1.64 
                 1.7 
                 260 
                 230 
                 4 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 39915764 
                 . 
                 A 
                 G 
                 PLEKHG2 
                 D 
                 1.64 
                 1.7 
                 260 
                 230 
                 4 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 39948307 
                 rs2304215 
                 C 
                 T 
                 SUPT5H 
                 . 
                 1.52 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0129 
               
               
                   
               
               
                 6 
                 19 
                 40327312 
                 rs3760924 
                 A 
                 G 
                 FBL 
                 . 
                 2.28 
                 2.54 
                 52 
                 46 
                 4 
                 9 
                 8 
                 0.0992 
               
               
                   
               
               
                 6 
                 19 
                 42603776 
                 rs1205817 
                 A 
                 G 
                 POU2F2 
                 . 
                 1.52 
                 1.7 
                 52 
                 46 
                 8 
                 12 
                 11 
                 0.1865 
               
               
                   
               
               
                 6 
                 19 
                 43268140 
                 rs11355507 
                 AG 
                 A 
                 PSG8 
                 . 
                 1.96 
                 1.7 
                 52 
                 46 
                 2 
                 3 
                 3 
                 0.0188 
               
               
                   
               
               
                 6 
                 19 
                 45296846 
                 rs66944506 
                 A 
                 AC 
                 CBLC 
                 . 
                 1.68 
                 1.98 
                 104 
                 92 
                 4 
                 7 
                 7 
                 0.0962 
               
               
                   
               
               
                 6 
                 19 
                 45297454 
                 rs1903831 
                 A 
                 C 
                 CBLC 
                 . 
                 1.68 
                 1.98 
                 104 
                 92 
                 4 
                 7 
                 7 
                 0.0863 
               
               
                   
               
               
                 6 
                 19 
                 47290651 
                 rs3826793 
                 G 
                 T 
                 SLC1A5 
                 . 
                 1.56 
                 1.63 
                 52 
                 46 
                 9 
                 13 
                 11 
                 0.2212 
               
               
                   
               
               
                 6 
                 19 
                 48735017 
                 rs140826611 
                 C 
                 CTT 
                 CARD8 
                 . 
                 2.28 
                 1.51 
                 52 
                 46 
                 3 
                 4 
                 4 
                 0.0575 
               
               
                   
               
               
                 6 
                 19 
                 49956688 
                 rs78750735 
                 T 
                 C 
                 ALDH16A1 
                 . 
                 1.8 
                 1.72 
                 208 
                 180 
                 39 
                 58 
                 52 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 49965131 
                 rs76844851 
                 G 
                 A 
                 ALDH16A1 
                 . 
                 1.8 
                 1.72 
                 208 
                 180 
                 39 
                 58 
                 52 
                 0.3313 
               
               
                   
               
               
                 6 
                 19 
                 49965131 
                 rs76844851 
                 G 
                 C 
                 ALDH16A1 
                 . 
                 1.8 
                 1.72 
                 208 
                 180 
                 39 
                 58 
                 52 
                 0.0149 
               
               
                   
               
               
                 6 
                 19 
                 49965132 
                 rs79109084 
                 G 
                 C 
                 ALDH16A1 
                 . 
                 1.8 
                 1.72 
                 208 
                 180 
                 39 
                 58 
                 52 
                 0.3313 
               
               
                   
               
               
                 6 
                 19 
                 51330423 
                 rs61752560 
                 C 
                 G 
                 KLK15 
                 . 
                 2.28 
                 1.81 
                 52 
                 46 
                 5 
                 8 
                 7 
                 0.1032 
               
               
                   
               
               
                 6 
                 19 
                 51582802 
                 rs199715229 
                 C 
                 T 
                 KLK14 
                 D 
                 4.57 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.0119 
               
               
                   
               
               
                 6 
                 19 
                 51585822 
                 rs769468261 
                 G 
                 A 
                 KLK14 
                 . 
                 4.57 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 54578105 
                 . 
                 C 
                 T 
                 TARM1 
                 . 
                 2.74 
                 . 
                 52 
                 46 
                 0 
                 3 
                 3 
                 0.0268 
               
               
                   
               
               
                 6 
                 19 
                 58118371 
                 rs78803667 
                 G 
                 A 
                 ZNF530 
                 D 
                 6.85 
                 3.39 
                 52 
                 46 
                 1 
                 3 
                 3 
                 0.0159 
               
               
                   
               
               
                 6 
                 19 
                 7688614 
                 rs2335521 
                 T 
                 C 
                 XAB2 
                 . 
                 2.85 
                 5.65 
                 52 
                 46 
                 1 
                 5 
                 5 
                 0.0407 
               
               
                   
               
               
                 6 
                 19 
                 7935408 
                 . 
                 A 
                 ACACTGGGG 
                 PRR36 
                 . 
                 6.49 
                 6.74 
                 218 
                 194 
                 1 
                 6 
                 6 
                 . 
               
               
                   
                   
                   
                   
                   
                 GTGAGGCA 
               
               
                   
                   
                   
                   
                   
                 GGGGGAGAG 
               
               
                   
                   
                   
                   
                   
                 AAAGGGGCCTG 
               
               
                   
                   
                   
                   
                   
                 (SEQ ID NO: 11) 
               
               
                   
               
               
                 6 
                 19 
                 7935423 
                 rs759755075 
                 CAGGGGGAG 
                 C 
                 PRR36 
                 . 
                 6.49 
                 6.74 
                 218 
                 194 
                 1 
                 6 
                 6 
                 . 
               
               
                   
                   
                   
                   
                 AGAAAGGGG 
               
               
                   
                   
                   
                   
                 CCTGCACTGG 
               
               
                   
                   
                   
                   
                 GGGTGAGGG 
               
               
                   
                   
                   
                   
                 (SEQ ID 
               
               
                   
                   
                   
                   
                 NO: 12) 
               
               
                   
               
               
                 6 
                 19 
                 7936105 
                 . 
                 A 
                 T 
                 PRR36 
                 . 
                 6.49 
                 6.74 
                 218 
                 194 
                 1 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 7937299 
                 . 
                 C 
                 T 
                 PRR36 
                 . 
                 6.49 
                 6.74 
                 218 
                 194 
                 1 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 19 
                 829555 
                 rs144713752 
                 C 
                 G 
                 AZU1 
                 . 
                 2.74 
                 . 
                 52 
                 46 
                 0 
                 3 
                 3 
                 0.0129 
               
               
                   
               
               
                 6 
                 19 
                 9236698 
                 rs111279560 
                 G 
                 GATGGT 
                 OR7G3 
                 . 
                 1.51 
                 1.64 
                 152 
                 134 
                 18 
                 26 
                 22 
                 0.3651 
               
               
                   
               
               
                 6 
                 19 
                 9236916 
                 rs75266995 
                 AG 
                 A 
                 OR7G3 
                 . 
                 1.51 
                 1.64 
                 152 
                 134 
                 18 
                 26 
                 22 
                 0.0317 
               
               
                   
               
               
                 6 
                 19 
                 9236969 
                 rs61751875 
                 G 
                 A 
                 OR7G3 
                 . 
                 1.51 
                 1.64 
                 152 
                 134 
                 18 
                 26 
                 22 
                 0.0357 
               
               
                   
               
               
                 6 
                 20 
                 23584368 
                 rs118095359 
                 G 
                 A 
                 CST9 
                 . 
                 1.83 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0129 
               
               
                   
               
               
                 6 
                 20 
                 31672812 
                 rs71349705 
                 C 
                 T 
                 BPIFB4 
                 . 
                 6.85 
                 . 
                 104 
                 92 
                 0 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 20 
                 31677295 
                 rs142982767 
                 C 
                 T 
                 BPIFB4 
                 . 
                 6.85 
                 . 
                 104 
                 92 
                 0 
                 3 
                 3 
                 0.0179 
               
               
                   
               
               
                 6 
                 20 
                 32005736 
                 rs116972153 
                 G 
                 A 
                 SNTA1 
                 . 
                 1.52 
                 1.7 
                 52 
                 46 
                 2 
                 3 
                 3 
                 0.0238 
               
               
                   
               
               
                 6 
                 20 
                 4228485 
                 rs3746669 
                 G 
                 T 
                 ADRA1D 
                 . 
                 1.5 
                 2.26 
                 52 
                 46 
                 11 
                 22 
                 17 
                 0.2887 
               
               
                   
               
               
                 6 
                 20 
                 44180813 
                 rs17348421 
                 G 
                 A 
                 WFDC8 
                 . 
                 2.28 
                 2.83 
                 52 
                 46 
                 2 
                 5 
                 4 
                 0.0585 
               
               
                   
               
               
                 6 
                 20 
                 44511257 
                 rs35972756 
                 G 
                 A 
                 ZSWIM1 
                 . 
                 4.57 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0159 
               
               
                   
               
               
                 6 
                 20 
                 44676727 
                 rs12481488 
                 T 
                 A 
                 SLC12A5 
                 . 
                 3.42 
                 3.39 
                 52 
                 46 
                 1 
                 3 
                 3 
                 0.0238 
               
               
                   
               
               
                 6 
                 20 
                 50307365 
                 rs117858424 
                 A 
                 G 
                 ATP9A 
                 . 
                 1.66 
                 2.26 
                 52 
                 46 
                 2 
                 4 
                 4 
                 0.0476 
               
               
                   
               
               
                 6 
                 2 
                 121997127 
                 rs147546143 
                 G 
                 GACGGT 
                 TFCP2L1 
                 . 
                 2.03 
                 2.26 
                 52 
                 46 
                 2 
                 4 
                 4 
                 0.0565 
               
               
                   
               
               
                 6 
                 2 
                 128466446 
                 . 
                 G 
                 A 
                 WDR33 
                 D 
                 1.9 
                 . 
                 208 
                 184 
                 0 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 128477849 
                 rs774069217 
                 C 
                 T 
                 WDR33 
                 D 
                 1.9 
                 . 
                 208 
                 184 
                 0 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 128522203 
                 rs117753184 
                 A 
                 T 
                 WDR33 
                 . 
                 1.9 
                 . 
                 208 
                 184 
                 0 
                 5 
                 5 
                 0.0258 
               
               
                   
               
               
                 6 
                 2 
                 128522852 
                 . 
                 G 
                 A 
                 WDR33 
                 . 
                 1.9 
                 . 
                 208 
                 184 
                 0 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 21 
                 34860749 
                 . 
                 CAATTA 
                 C 
                 DNAJC28 
                 . 
                 1.9 
                 2.83 
                 52 
                 46 
                 4 
                 10 
                 9 
                 0.1667 
               
               
                   
               
               
                 6 
                 21 
                 42615293 
                 rs2252576 
                 C 
                 T 
                 BACE2 
                 . 
                 1.52 
                 2.83 
                 52 
                 46 
                 2 
                 5 
                 4 
                 0.0675 
               
               
                   
               
               
                 6 
                 21 
                 43412786 
                 rs200509586 
                 GTCA 
                 G 
                 ZBTB21 
                 . 
                 11.41 
                 5.65 
                 52 
                 46 
                 1 
                 5 
                 5 
                 0.0109 
               
               
                   
               
               
                 6 
                 2 
                 153515710 
                 rs141445791 
                 A 
                 C 
                 PRPF40A 
                 . 
                 1.56 
                 . 
                 104 
                 90 
                 0 
                 4 
                 4 
                 0.0278 
               
               
                   
               
               
                 6 
                 2 
                 153515879 
                 rs767401165 
                 A 
                 G 
                 PRPF40A 
                 . 
                 1.56 
                 . 
                 104 
                 90 
                 0 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 169791766 
                 . 
                 G 
                 A 
                 ABCB11 
                 D 
                 4.57 
                 3.39 
                 156 
                 138 
                 1 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 169801131 
                 rs118109635 
                 G 
                 A 
                 ABCB11 
                 D 
                 4.57 
                 3.39 
                 156 
                 138 
                 1 
                 3 
                 3 
                 0.0129 
               
               
                   
               
               
                 6 
                 2 
                 169853135 
                 . 
                 A 
                 G 
                 ABCB11 
                 . 
                 4.57 
                 3.39 
                 156 
                 138 
                 1 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 175304621 
                 rs67227536 
                 C 
                 G 
                 GPR155 
                 . 
                 6.85 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 3 
                 0.0139 
               
               
                   
               
               
                 6 
                 2 
                 175333632 
                 rs28588913 
                 G 
                 A 
                 GPR155 
                 . 
                 6.85 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 3 
                 0.0248 
               
               
                   
               
               
                 6 
                 2 
                 202498027 
                 rs78297522 
                 T 
                 C 
                 TMEM237 
                 . 
                 1.96 
                 1.7 
                 52 
                 46 
                 2 
                 3 
                 3 
                 0.0298 
               
               
                   
               
               
                 6 
                 22 
                 19420778 
                 rs3747064 
                 T 
                 A 
                 MRPL40 
                 . 
                 1.52 
                 4.52 
                 52 
                 46 
                 1 
                 4 
                 4 
                 0.0714 
               
               
                   
               
               
                 6 
                 22 
                 24313530 
                 rs199896117 
                 GGA 
                 G 
                 DDTL 
                 . 
                 2.28 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0278 
               
               
                   
               
               
                 6 
                 22 
                 24919647 
                 rs118163237 
                 G 
                 A 
                 UPB1 
                 D 
                 1.83 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0188 
               
               
                   
               
               
                 6 
                 2 
                 231077154 
                 rs41309096 
                 G 
                 A 
                 SP110 
                 . 
                 1.83 
                 1.7 
                 52 
                 46 
                 4 
                 6 
                 6 
                 0.0883 
               
               
                   
               
               
                 6 
                 2 
                 30862980 
                 rs12466818 
                 C 
                 T 
                 LCLAT1 
                 . 
                 1.52 
                 1.98 
                 52 
                 46 
                 8 
                 14 
                 11 
                 0.2222 
               
               
                   
               
               
                 6 
                 2 
                 31412347 
                 rs78099670 
                 G 
                 A 
                 CAPN14 
                 . 
                 7.3 
                 1.51 
                 260 
                 230 
                 3 
                 4 
                 4 
                 0.0179 
               
               
                   
               
               
                 6 
                 2 
                 31414833 
                 . 
                 G 
                 T 
                 CAPN14 
                 D 
                 7.3 
                 1.51 
                 260 
                 230 
                 3 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 31414844 
                 rs147299374 
                 C 
                 T 
                 CAPN14 
                 D 
                 7.3 
                 1.51 
                 260 
                 230 
                 3 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 31414959 
                 rs141014145 
                 A 
                 G 
                 CAPN14 
                 D 
                 7.3 
                 1.51 
                 260 
                 230 
                 3 
                 4 
                 4 
                 0.0149 
               
               
                   
               
               
                 6 
                 2 
                 31422395 
                 rs200657395 
                 TCTC 
                 T 
                 CAPN14 
                 . 
                 7.3 
                 1.51 
                 260 
                 230 
                 3 
                 4 
                 4 
                 0.0139 
               
               
                   
               
               
                 6 
                 2 
                 55491007 
                 rs369772725 
                 G 
                 GA 
                 MTIF2 
                 . 
                 2.75 
                 5.18 
                 44 
                 34 
                 1 
                 4 
                 4 
                 0.0486 
               
               
                   
               
               
                 6 
                 2 
                 98128073 
                 . 
                 G 
                 * 
                 ANKRD36B 
                 . 
                 1.86 
                 2.71 
                 116 
                 110 
                 14 
                 36 
                 33 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 98128073 
                 rs373085949 
                 G 
                 A 
                 ANKRD36B 
                 . 
                 1.86 
                 2.71 
                 116 
                 110 
                 14 
                 36 
                 33 
                 . 
               
               
                   
               
               
                 6 
                 2 
                 98164184 
                 rs13001728 
                 C 
                 G 
                 ANKRD36B 
                 . 
                 1.86 
                 2.71 
                 116 
                 110 
                 14 
                 36 
                 33 
                 0.1796 
               
               
                   
               
               
                 6 
                 3 
                 100593675 
                 rs79152576 
                 T 
                 C 
                 ABI3BP 
                 . 
                 2.28 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0139 
               
               
                   
               
               
                 6 
                 3 
                 107097080 
                 rs138204694 
                 CAAATG 
                 C 
                 CCDC54 
                 . 
                 2.61 
                 4.52 
                 52 
                 46 
                 1 
                 4 
                 4 
                 0.0317 
               
               
                   
               
               
                 6 
                 3 
                 111780629 
                 rs73853301 
                 C 
                 T 
                 TMPRSS7 
                 . 
                 3.04 
                 4.52 
                 104 
                 92 
                 2 
                 8 
                 6 
                 0.0258 
               
               
                   
               
               
                 6 
                 3 
                 111780630 
                 rs73853302 
                 C 
                 T 
                 TMPRSS7 
                 . 
                 3.04 
                 4.52 
                 104 
                 92 
                 2 
                 8 
                 6 
                 0.0258 
               
               
                   
               
               
                 6 
                 3 
                 120428621 
                 rs11720353 
                 T 
                 C 
                 RABL3 
                 . 
                 1.68 
                 1.58 
                 52 
                 46 
                 5 
                 7 
                 7 
                 0.127 
               
               
                   
               
               
                 6 
                 3 
                 122002576 
                 rs117375173 
                 A 
                 G 
                 CASR 
                 D 
                 1.71 
                 6.78 
                 104 
                 92 
                 1 
                 6 
                 6 
                 0.0446 
               
               
                   
               
               
                 6 
                 3 
                 122002644 
                 rs768660050 
                 G 
                 T 
                 CASR 
                 D 
                 1.71 
                 6.78 
                 104 
                 92 
                 1 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 3 
                 133331230 
                 rs71317417 
                 C 
                 T 
                 TOPBP1 
                 . 
                 2.28 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0437 
               
               
                   
               
               
                 6 
                 3 
                 182871464 
                 rs500288 
                 A 
                 G 
                 LAMP3 
                 . 
                 3.42 
                 1.7 
                 52 
                 46 
                 2 
                 3 
                 3 
                 0.0317 
               
               
                   
               
               
                 6 
                 3 
                 196296182 
                 rs79085393 
                 G 
                 C 
                 FBXO45 
                 . 
                 1.9 
                 1.88 
                 52 
                 46 
                 3 
                 5 
                 5 
                 0.0665 
               
               
                   
               
               
                 6 
                 3 
                 46714821 
                 rs11130104 
                 C 
                 G 
                 ALS2CL 
                 . 
                 1.56 
                 1.88 
                 52 
                 46 
                 18 
                 30 
                 20 
                 0.3571 
               
               
                   
               
               
                 6 
                 3 
                 56682841 
                 rs71621834 
                 A 
                 C 
                 FAM208A 
                 . 
                 3.18 
                 2.36 
                 52 
                 44 
                 2 
                 4 
                 4 
                 0.0327 
               
               
                   
               
               
                 6 
                 3 
                 58620105 
                 rs76752946 
                 G 
                 C 
                 FAM3D 
                 . 
                 2.61 
                 4.52 
                 52 
                 46 
                 1 
                 4 
                 4 
                 0.0308 
               
               
                   
               
               
                 6 
                 4 
                 141458699 
                 rs149594258 
                 A 
                 C 
                 ELMOD2 
                 . 
                 1.96 
                 3.39 
                 52 
                 46 
                 1 
                 3 
                 3 
                 0.0208 
               
               
                   
               
               
                 6 
                 4 
                 184367558 
                 rs10533201 
                 TCTG 
                 T 
                 CDKN2AIP 
                 . 
                 1.66 
                 2.01 
                 52 
                 46 
                 9 
                 16 
                 13 
                 0.244 
               
               
                   
               
               
                 6 
                 4 
                 20751278 
                 rs2322688 
                 A 
                 G 
                 KCNIP4 
                 . 
                 1.65 
                 1.84 
                 52 
                 46 
                 8 
                 13 
                 11 
                 0.1726 
               
               
                   
               
               
                 6 
                 4 
                 48517296 
                 rs757286932 
                 C 
                 A 
                 FRYL 
                 . 
                 1.52 
                 2.83 
                 260 
                 230 
                 2 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 4 
                 48545814 
                 rs10517225 
                 A 
                 T 
                 FRYL 
                 . 
                 1.52 
                 2.83 
                 260 
                 230 
                 2 
                 5 
                 5 
                 0.0238 
               
               
                   
               
               
                 6 
                 4 
                 48546796 
                 rs78799039 
                 A 
                 G 
                 FRYL 
                 . 
                 1.52 
                 2.83 
                 260 
                 230 
                 2 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 4 
                 48549674 
                 rs776615697 
                 GAGA 
                 G 
                 FRYL 
                 . 
                 1.52 
                 2.83 
                 260 
                 230 
                 2 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 4 
                 48559138 
                 rs779161058 
                 AG 
                 A 
                 FRYL 
                 . 
                 1.52 
                 2.83 
                 260 
                 230 
                 2 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 4 
                 48993993 
                 rs749533750 
                 CTTG 
                 C 
                 CWH43 
                 . 
                 1.71 
                 . 
                 104 
                 92 
                 0 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 4 
                 49034669 
                 rs147750792 
                 CA 
                 C 
                 CWH43 
                 . 
                 1.71 
                 . 
                 104 
                 92 
                 0 
                 3 
                 3 
                 0.0149 
               
               
                   
               
               
                 6 
                 4 
                 69094459 
                 rs75647314 
                 C 
                 A 
                 TMPRSS11B 
                 . 
                 3.04 
                 2.26 
                 104 
                 92 
                 2 
                 4 
                 4 
                 0.0278 
               
               
                   
               
               
                 6 
                 4 
                 69096987 
                 rs575638339 
                 C 
                 T 
                 TMPRSS11B 
                 D 
                 3.04 
                 2.26 
                 104 
                 92 
                 2 
                 4 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 4 
                 70078281 
                 rs62298955 
                 G 
                 C 
                 UGT2B11 
                 . 
                 1.96 
                 3.39 
                 52 
                 46 
                 1 
                 3 
                 3 
                 0.0476 
               
               
                   
               
               
                 6 
                 4 
                 77940418 
                 rs28541859 
                 T 
                 A 
                 SEPT11 
                 . 
                 1.52 
                 2.26 
                 52 
                 46 
                 4 
                 8 
                 8 
                 0.1012 
               
               
                   
               
               
                 6 
                 5 
                 151784206 
                 rs145273801 
                 G 
                 A 
                 NMUR2 
                 . 
                 1.71 
                 1.7 
                 104 
                 92 
                 2 
                 3 
                 3 
                 0.0248 
               
               
                   
               
               
                 6 
                 5 
                 151784490 
                 rs762380505 
                 C 
                 A 
                 NMUR2 
                 D 
                 1.71 
                 1.7 
                 104 
                 92 
                 2 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 5 
                 170221307 
                 rs117380156 
                 G 
                 A 
                 GABRP 
                 . 
                 3.42 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 3 
                 0.0159 
               
               
                   
               
               
                 6 
                 5 
                 170236578 
                 rs558177227 
                 C 
                 T 
                 GABRP 
                 D 
                 3.42 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 5 
                 74998426 
                 rs17649248 
                 G 
                 A 
                 POC5 
                 . 
                 1.62 
                 1.98 
                 104 
                 92 
                 12 
                 21 
                 19 
                 0.119 
               
               
                   
               
               
                 6 
                 5 
                 75008193 
                 rs2047059 
                 T 
                 C 
                 POC5 
                 . 
                 1.62 
                 1.98 
                 104 
                 92 
                 12 
                 21 
                 19 
                 0.2153 
               
               
                   
               
               
                 6 
                 6 
                 106978193 
                 rs17495742 
                 A 
                 G 
                 AIM1 
                 . 
                 1.76 
                 2.79 
                 154 
                 138 
                 2 
                 5 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 6 
                 106991361 
                 rs61741114 
                 T 
                 C 
                 AIM1 
                 D 
                 1.76 
                 2.79 
                 154 
                 138 
                 2 
                 5 
                 4 
                 . 
               
               
                   
               
               
                 6 
                 6 
                 107016343 
                 rs3747789 
                 T 
                 G 
                 AIM1 
                 . 
                 1.76 
                 2.79 
                 154 
                 138 
                 2 
                 5 
                 4 
                 0.0694 
               
               
                   
               
               
                 6 
                 6 
                 10927469 
                 rs770638323 
                 A 
                 G 
                 SYCP2L 
                 . 
                 3.42 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 6 
                 10935424 
                 rs181416897 
                 C 
                 T 
                 SYCP2L 
                 . 
                 3.42 
                 3.39 
                 104 
                 92 
                 1 
                 3 
                 2 
                 0.0109 
               
               
                   
               
               
                 6 
                 6 
                 142487469 
                 rs225656 
                 C 
                 A 
                 VTA1 
                 . 
                 1.76 
                 1.91 
                 104 
                 92 
                 16 
                 27 
                 25 
                 0.1845 
               
               
                   
               
               
                 6 
                 6 
                 142510676 
                 rs3830800 
                 GTATT 
                 G 
                 VTA1 
                 . 
                 1.76 
                 1.91 
                 104 
                 92 
                 16 
                 27 
                 25 
                 0.1468 
               
               
                   
               
               
                 6 
                 6 
                 26410148 
                 rs77721150 
                 T 
                 C 
                 BTN3A1 
                 . 
                 2.71 
                 4.52 
                 156 
                 138 
                 2 
                 8 
                 8 
                 0.0248 
               
               
                   
               
               
                 6 
                 6 
                 26410227 
                 rs7770214 
                 G 
                 A 
                 BTN3A1 
                 . 
                 2.71 
                 4.52 
                 156 
                 138 
                 2 
                 8 
                 8 
                 0.0308 
               
               
                   
               
               
                 6 
                 6 
                 26410266 
                 . 
                 T 
                 C 
                 BTN3A1 
                 . 
                 2.71 
                 4.52 
                 156 
                 138 
                 2 
                 8 
                 8 
                 . 
               
               
                   
               
               
                 6 
                 6 
                 28268497 
                 rs2281043 
                 C 
                 T 
                 PGBD1 
                 . 
                 2.85 
                 2.83 
                 52 
                 46 
                 4 
                 10 
                 9 
                 0.1448 
               
               
                   
               
               
                 6 
                 6 
                 30574428 
                 . 
                 A 
                 G 
                 PPP1R10 
                 . 
                 3.42 
                 . 
                 52 
                 46 
                 0 
                 3 
                 3 
                 0.0218 
               
               
                   
               
               
                 6 
                 6 
                 30618867 
                 . 
                 T 
                 C 
                 C6orf136 
                 . 
                 1.76 
                 2.83 
                 52 
                 46 
                 2 
                 5 
                 4 
                 0.0595 
               
               
                   
               
               
                 6 
                 6 
                 30670948 
                 rs536243116 
                 C 
                 T 
                 MDC1 
                 D 
                 2.11 
                 3.39 
                 156 
                 138 
                 2 
                 6 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 6 
                 30679289 
                 rs147822906 
                 G 
                 C 
                 MDC1 
                 . 
                 2.11 
                 3.39 
                 156 
                 138 
                 2 
                 6 
                 5 
                 0.0198 
               
               
                   
               
               
                 6 
                 6 
                 30679510 
                 rs17189329 
                 G 
                 A 
                 MDC1 
                 . 
                 2.11 
                 3.39 
                 156 
                 138 
                 2 
                 6 
                 5 
                 0.0595 
               
               
                   
               
               
                 6 
                 6 
                 31733650 
                 rs707936 
                 G 
                 A 
                 VWA7 
                 . 
                 2.08 
                 . 
                 52 
                 46 
                 0 
                 5 
                 4 
                 0.0615 
               
               
                   
               
               
                 6 
                 6 
                 31948421 
                 . 
                 TCTC 
                 T 
                 STK19 
                 . 
                 2.15 
                 1.51 
                 52 
                 46 
                 6 
                 8 
                 8 
                 0.0972 
               
               
                   
               
               
                 6 
                 6 
                 36929653 
                 rs144897670 
                 C 
                 T 
                 PI16 
                 . 
                 3.04 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0129 
               
               
                   
               
               
                 6 
                 6 
                 397261 
                 rs34318727 
                 G 
                 A 
                 IRF4 
                 . 
                 2.08 
                 5.65 
                 52 
                 46 
                 1 
                 5 
                 5 
                 0.0496 
               
               
                   
               
               
                 6 
                 6 
                 46133282 
                 rs16874326 
                 T 
                 C 
                 ENPP5 
                 D 
                 1.52 
                 3.39 
                 52 
                 46 
                 1 
                 3 
                 3 
                 0.0407 
               
               
                   
               
               
                 6 
                 6 
                 72011086 
                 rs16880821 
                 C 
                 T 
                 OGFRL1 
                 . 
                 4.57 
                 . 
                 52 
                 46 
                 0 
                 3 
                 3 
                 0.0149 
               
               
                   
               
               
                 6 
                 6 
                 87994504 
                 rs35259282 
                 C 
                 T 
                 GJB7 
                 D 
                 2.28 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 0.0188 
               
               
                   
               
               
                 6 
                 6 
                 87994537 
                 rs112552839 
                 G 
                 A 
                 GJB7 
                 D 
                 2.28 
                 2.26 
                 104 
                 92 
                 1 
                 2 
                 2 
                 . 
               
               
                   
               
               
                 6 
                 7 
                 100230618 
                 rs41303468 
                 A 
                 T 
                 TFR2 
                 . 
                 2.28 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0139 
               
               
                   
               
               
                 6 
                 7 
                 140125701 
                 rs760033770 
                 G 
                 A 
                 RAB19 
                 . 
                 2.54 
                 5.65 
                 156 
                 138 
                 1 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 7 
                 140125753 
                 rs771901851 
                 G 
                 A 
                 RAB19 
                 D 
                 2.54 
                 5.65 
                 156 
                 138 
                 1 
                 5 
                 5 
                 . 
               
               
                   
               
               
                 6 
                 7 
                 140174292 
                 rs10709936 
                 CA 
                 C 
                 MKRN1 
                 . 
                 1.95 
                 1.66 
                 42 
                 38 
                 8 
                 12 
                 10 
                 0.1766 
               
               
                   
               
               
                 6 
                 7 
                 142562051 
                 rs143667567 
                 C 
                 CCCTCCT 
                 EPHB6 
                 . 
                 2.74 
                 1.61 
                 148 
                 138 
                 4 
                 6 
                 6 
                 0.0238 
               
               
                   
               
               
                 6 
                 7 
                 142562051 
                 rs143667567 
                 C 
                 CCCT 
                 EPHB6 
                 . 
                 2.74 
                 1.61 
                 148 
                 138 
                 4 
                 6 
                 6 
                 0.0139 
               
               
                   
               
               
                 6 
                 7 
                 142565743 
                 rs8177158 
                 G 
                 A 
                 EPHB6 
                 . 
                 2.74 
                 1.61 
                 148 
                 138 
                 4 
                 6 
                 6 
                 . 
               
               
                   
               
               
                 6 
                 7 
                 156468559 
                 rs3823617 
                 T 
                 C 
                 RNF32 
                 . 
                 1.52 
                 1.7 
                 52 
                 46 
                 4 
                 6 
                 6 
                 0.1111 
               
               
                   
               
               
                 6 
                 7 
                 28534518 
                 rs77306029 
                 C 
                 T 
                 CREB5 
                 . 
                 2.28 
                 2.26 
                 52 
                 46 
                 2 
                 4 
                 4 
                 0.0397 
               
               
                   
               
               
                 6 
                 7 
                 72984917 
                 . 
                 CGTT 
                 C 
                 TBL2 
                 . 
                 4.57 
                 . 
                 52 
                 46 
                 0 
                 5 
                 5 
                 0.0159 
               
               
                   
               
               
                 6 
                 8 
                 17104886 
                 rs145945235 
                 G 
                 A 
                 VPS37A 
                 . 
                 1.79 
                 2.44 
                 44 
                 36 
                 2 
                 4 
                 4 
                 0.0526 
               
               
                   
               
               
                 6 
                 8 
                 37791988 
                 rs201462725 
                 GT 
                 G 
                 GOT1L1 
                 . 
                 2.74 
                 1.7 
                 52 
                 46 
                 2 
                 3 
                 3 
                 0.0337 
               
               
                   
               
               
                 6 
                 8 
                 87163770 
                 rs150698519 
                 G 
                 T 
                 ATP6V0D2 
                 . 
                 1.83 
                 2.26 
                 52 
                 46 
                 1 
                 2 
                 2 
                 0.0149 
               
               
                   
               
               
                 6 
                 8 
                 95188916 
                 rs67774240 
                 G 
                 A 
                 CDH17 
                 . 
                 1.83 
                 3.39 
                 156 
                 138 
                 1 
                 3 
                 3 
                 0.0278 
               
               
                   
               
               
                 6 
                 8 
                 95189955 
                 rs138007982 
                 G 
                 T 
                 CDH17 
                 . 
                 1.83 
                 3.39 
                 156 
                 138 
                 1 
                 3 
                 3 
                 0.0139 
               
               
                   
               
               
                 6 
                 8 
                 95201518 
                 rs749070399 
                 TAAAAA 
                 T 
                 CDH17 
                 . 
                 1.83 
                 3.39 
                 156 
                 138 
                 1 
                 3 
                 3 
                 . 
               
               
                   
               
               
                 6 
                 9 
                 100693386 
                 rs201990544 
                 CACT 
                 C 
                 HEMGN 
                 . 
                 6.85 
                 3.39 
                 52 
                 46 
                 1 
                 3 
                 3 
                 0.0129 
               
               
                   
               
               
                 6 
                 9 
                 101984010 
                 rs201959100 
                 G 
                 A 
                 ALG2 
                 D 
                 6.85 
                 . 
                 52 
                 46 
                 0 
                 3 
                 3 
                 0.0188 
               
               
                   
               
               
                 6 
                 9 
                 127074783 
                 rs139169292 
                 TC 
                 T 
                 NEK6 
                 . 
                 1.59 
                 2.26 
                 104 
                 92 
                 8 
                 16 
                 16 
                 0.0923 
               
               
                   
               
               
                 6 
                 9 
                 127076271 
                 rs56045213 
                 A 
                 G 
                 NEK6 
                 . 
                 1.59 
                 2.26 
                 104 
                 92 
                 8 
                 16 
                 16 
                 0.0923 
               
               
                   
               
               
                 6 
                 9 
                 5892552 
                 rs148372841 
                 G 
                 C 
                 MLANA 
                 . 
                 9.13 
                 4.52 
                 52 
                 46 
                 1 
                 4 
                 4 
                 0.0139 
               
               
                   
               
               
                 6 
                 9 
                 95411725 
                 rs72756427 
                 G 
                 A 
                 IPPK 
                 . 
                 2.74 
                 1.7 
                 52 
                 46 
                 2 
                 3 
                 3 
                 0.0476 
               
               
                   
               
               
                 6 
                 X 
                 31089629 
                 rs7057057 
                 C 
                 A 
                 FTHL17 
                 . 
                 1.73 
                 2.26 
                 52 
                 46 
                 3 
                 6 
                 5 
                 0.1453 
               
               
                   
               
               
                 6 
                 X 
                 49114808 
                 . 
                 C 
                 A 
                 FOXP3 
                 D 
                 2.88 
                 1.88 
                 52 
                 46 
                 3 
                 5 
                 4 
                 0.0393 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 10 
               
               
                   
               
               
                 Susceptibility genes unique to disease duration with 
               
               
                 exonic variants in Rheumatoid Arthritis disease. 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 AMPD1 
                 ATXN7 
                 GPR84 
                 OR7G3 
               
               
                   
                 PPARGC18 
                 C10orf142 
                 OR9K2 
                 CST9 
               
               
                   
                 ATP6V0A4 
                 CH17-360D5.1 
                 OR6C74 
                 WDR33 
               
               
                   
                 HKDC1 
                 NPY4R 
                 OR6C75 
                 DNAJC28 
               
               
                   
                 C1orf167 
                 LRRC39 
                 CATSPER4 
                 DDTL 
               
               
                   
                 SLCO1B3 
                 GPSM2 
                 NR2C1 
                 UPB1 
               
               
                   
                 MYH1 
                 ITGA10 
                 SERPINA10 
                 LCLAT1 
               
               
                   
                 SGCA 
                 LCE5A 
                 RORA 
                 CASR 
               
               
                   
                 RYR1 
                 OR4A15 
                 TPSG1 
                 CDKN2AIP 
               
               
                   
                 KIZ 
                 OR52N4 
                 NEK8 
                 FRYL 
               
               
                   
                 TPTE 
                 SLAMF8 
                 HEATR9 
                 CWH43 
               
               
                   
                 LRP2 
                 MTA2 
                 PNMT 
                 NMUR2 
               
               
                   
                 DYSF 
                 EML3 
                 ABCC3 
                 GABRP 
               
               
                   
                 COL6A6 
                 GPR161 
                 NACA2 
                 MDC1 
               
               
                   
                 CP 
                 IL18BP 
                 CACNG5 
                 ENPPS 
               
               
                   
                 HTR3E 
                 PANO1 
                 AURKB 
                 RAB19 
               
               
                   
                 TET2 
                 LHX4 
                 PLEKHG2 
                 EPHB6 
               
               
                   
                 THBS2 
                 LAD1 
                 PSG8 
                 GOT1L1 
               
               
                   
                 FLNC 
                 SYT14 
                 CBLC 
                 HEMGN 
               
               
                   
                 SSPO 
                 FAAP20 
                 CARD8 
                 ALG2 
               
               
                   
                 PKHD1L1 
                 HIST4H4 
                 TARM1 
                 FTHL17 
               
               
                   
                 IL3RA 
                 OR14C36 
                 PRR36