Patent Publication Number: US-2021169357-A1

Title: System and method for using integrated sensor arrays to measure and analyze multiple biosignatures in real time

Description:
CROSS REFERENCES TO RELATED APPLICATIONS 
     This application is related to and claims priority from the following U.S. patents and patent applications. This application is a continuation of U.S. patent application Ser. No. 15/909,141 filed on Mar. 1, 2018, which claims priority to Provisional Patent Application No. 62/466,022, filed on Mar. 2, 2017. Each of the above listed applications is incorporated herein by reference in its entirety. 
    
    
     BACKGROUND OF THE INVENTION 
     1. Field of the Invention 
     The present invention relates to biometric signal detection and analytics of data collected from multiple sensors and external sources. 
     2. Description of the Prior Art 
     It is generally known in the prior art to provide sensors to detect biometric data and to provide biosignatures. 
     WIPO Publication No. WO2016061362 for sweat sensing device communication security and compliance by inventors Heikenfeld, et al., filed Oct. 15, 2015 and published Jun. 16, 2016, is directed to an invention that addresses confounding difficulties involving continuous sweat analyte measurement. Specifically, the invention provides: at least one component capable of monitoring whether a sweat sensing device is in sufficient contact with a wearer&#39;s skin to allow proper device operation; at least one component capable of monitoring whether the device is operating on a wearer&#39;s skin; at least one means of determining whether the device wearer is a target individual within a probability range; at least one component capable of generating and communicating alert messages to the device user(s) related to: wearer safety, wearer physiological condition, compliance with a requirement to wear a device, device operation; compliance with a behavior requirement, or other purposes that may be derived from sweat sensor data; and the ability to utilize aggregated sweat sensor data that may be correlated with information external to the device to enhance the predictive capabilities of the device. 
     Published article by Rose, et al., in IEEE Transactions on Biomedical Engineering, Nov. 6, 2014, pages 1-9, discusses an adhesive RFID sensor patch for monitoring of sweat electrolytes. 
     U.S. Publication No. 20160287148 for device for measuring biological fluids by inventors Pizer, et al., filed Jun. 9, 2016 and published Oct. 6, 2016, is directed to a flexible, multi-layered device for automatically sensing sweat biomarkers, storing and transmitting sensed data via wireless network to a computing device having software applications operable thereon for receiving and analyzing the sensed data. The device is functional in extreme conditions, including extremely hot temperatures, extremely cold temperatures, high salinity, high altitude, extreme pHs, and/or extreme pressures. 
     U.S. Pat. No. 9,579,024 for system and method for measuring biological fluid biomarkers by inventors Nyberg, et al., filed Jun. 9, 2016 and issued Feb. 28, 2017, is directed to systems and methods of analyzing biological fluid biomarkers, calculating biomarker data, transmitting data to a transceiver device, and storing the data and/or analytics in a database and/or on at least one remote computer server. 
     U.S. Publication No. 20160290952 for method for manufacturing a biological fluid sensor by inventors Pizer, et al., filed Jun. 9, 2016 and published Oct. 6, 2016, is directed to a method of fabrication for a physiological sensor with electronic, electrochemical and chemical components. The fabrication method comprises steps for manufacturing an apparatus comprising at least one electrochemical sensor, a microcontroller, and a transceiver. The physiological sensor is operable to analyze biological fluids such as sweat. 
     U.S. Publication No. 20150126834 for wearable electrochemical sensors by inventors Wang, et al., filed May 10, 2013 and published May 7, 2015, is directed to methods, structures, devices and systems for fabricating and implementing electrochemical biosensors and chemical sensors. In one aspect, a method of producing an epidermal biosensor includes forming an electrode pattern onto a coated surface of a paper-based substrate to form an electrochemical sensor, the electrode pattern including an electrically conductive material and an electrically insulative material configured in a particular design layout, and attaching an adhesive sheet on a surface of the electrochemical sensor having the electrode pattern, the adhesive sheet capable of adhering to skin or a wearable item, in which the electrochemical sensor, when attached to the skin or the wearable item, is operable to detect chemical analytes within an external environment. 
     U.S. Publication No. 20150297104 for system and method for non-invasive autonomic nerve activity monitoring by inventors Chen, et al., filed Dec. 9, 2103 and published Oct. 22, 2015, is directed to a system and method for monitoring nerve activity in a subject. The system includes a plurality of electrodes placed in proximity to skin of the subject, an amplifier electrically connected to the electrodes and configured to generate a plurality of amplified signals corresponding to electrical signals received from the subject through the electrodes, and a signal processor. The signal processor applies a high-pass filter to the amplified signals to generate filtered signals from the amplified signals, identifies autonomic nerve activity in the plurality of filtered signals; and generates an output signal corresponding to the filtered signals. The high-pass filter attenuates a plurality of the amplified signals having frequencies that correspond to heart muscle activity during a heartbeat. 
     WIPO Publication No. WO2017058806 for wearable sensor arrays for in-situ body fluid analysis by inventors Javey, et al., filed Sep. 27, 2016 and published Apr. 6, 2017, is directed to a wearable sensing platform including sensors and circuits to sense aspects of a user&#39;s state by analyzing bodily fluids, such as sweat and/or urine, and a user&#39;s temperature. A sensor array senses a plurality of different body fluid analytes, optionally at the same time. A signal conditioner is coupled to the sensor array. The signal conditioner conditions sensor signals. An interface is configured to transmit information corresponding to the conditioned sensor signals to a remote computing device. The wearable sensing platform may include a flexible printed circuit board to enable the wearable sensing platform, or a portion thereof, to conform to a portion of the user&#39;s body. 
     Published article by Gao, et al. entitled “Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis” in Nature, vol. 529, no. 7587, pages 509-514 (January 2016), discusses a flexible integrated sensing array for simultaneous and selective screening of a panel of biomarkers in sweat. 
     U.S. Pat. No. 8,204,786 for physiological and environmental monitoring systems and methods by inventors LeBoeuf, et al., filed Jan. 6, 2011 and issued Jun. 19, 2012, is directed to systems and methods for monitoring various physiological and environmental factors, as well as systems and methods for using this information for a plurality of useful purposes. Real-time, noninvasive health and environmental monitors include a plurality of compact sensors integrated within small, low-profile devices. Physiological and environmental data is collected and wirelessly transmitted into a wireless network, where the data is stored and/or processed. This information is then used to support a variety of useful methods, such as clinical trials, marketing studies, biofeedback, entertainment, and others. 
     U.S. Pat. No. 8,251,903 for noninvasive physiological analysis using excitation-sensor modules and related devices and methods by inventors LeBoeuf, et al., filed Oct. 23, 2008 and issued Aug. 28, 2012, is directed to methods and apparatus for qualifying and quantifying excitation-dependent physiological information extracted from wearable sensors in the midst of interference from unwanted sources. An organism is interrogated with at least one excitation energy, energy response signals from two or more distinct physiological regions are sensed, and these signals are processed to generate an extracted signal. The extracted signal is compared with a physiological model to qualify and/or quantify a physiological property. Additionally, important physiological information can be qualified and quantified by comparing the excitation wavelength-dependent response, measured via wearable sensors, with a physiological model. 
     U.S. Pat. No. 8,961,415 for methods and apparatus for assessing physiological conditions by inventors LeBoeuf, et al., filed Feb. 22, 2010 and issued Feb. 24, 2015, is directed to a monitoring apparatus and methods for assessing a physiological condition of a subject. At least two types of physiological information are detected from a subject via a portable monitoring device associated with the subject, and an assessment of a physiological condition of the subject is made using the at least two types of physiological information, wherein each type of physiological information is individually insufficient to make the physiological condition assessment. Environmental information from a vicinity of a subject also may be detected, and an assessment of a physiological condition of the subject may be made using the environmental information in combination with the physiological information. Exemplary physiological information may include subject heart rate, subject activity level, subject tympanic membrane temperature, and subject breathing rate. Exemplary environmental information may include humidity level information in the vicinity of the subject. An exemplary physiological condition assessment may be subject hydration level. 
     U.S. Pat. No. 8,788,002 for light-guiding devices and monitoring devices incorporating same by inventors LeBoeuf, et al., filed Dec. 14, 2012 and issued Jul. 22, 2014, is directed to a monitoring device configured to be attached to the ear of a person including a base, an earbud housing extending outwardly from the base that is configured to be positioned within an ear of a subject, and a cover surrounding the earbud housing. The base includes a speaker, an optical emitter, and an optical detector. The cover includes light transmissive material that is in optical communication with the optical emitter and the optical detector and serves as a light guide to deliver light from the optical emitter into the ear canal of the subject wearing the device at one or more predetermined locations and to collect light external to the earbud housing and deliver the collected light to the optical detector. 
     U.S. Pat. No. 9,427,191 for apparatus and methods for estimating time-state physiological parameters by inventor LeBoeuf, filed Jul. 12, 2012 and issued Aug. 30, 2016, is directed to a method of determining a value of a physiological parameter for a subject at a selected state includes obtaining, via a device attached to the subject, a value of the physiological parameter of the subject at a particular time-of-day, and applying a time-dependent relationship function to the obtained physiological parameter value via a processor to determine a value of the physiological parameter at the selected state. 
     U.S. Publication No. 20160256066 for method and system to measure physiological signals or to electrically stimulate a body part by inventors Chetelat, et al., filed Oct. 21, 2013 and published Sep. 8, 2016, is directed to a body electrode system including a set of standalone electrodes units for measuring physiological signals of a body part and/or electrically stimulate a body part. A connecting garment provides electrical connection between each standalone unit of the set. Each unit of the set is individually positionable at a specific chosen position onto the body to be sensed and/or stimulated. The garment is electrically connectable to said units, preferably after placement of said set onto the body. 
     U.S. Publication No. 20150173677 for measurement device for measuring bio-impedance and/or a bio-potential of a human or animal body by inventors Chetelat, et al., filed Dec. 19, 2014 and published Jun. 25, 2015, is directed to a measurement device for measuring a bio-impedance and/or a bio-potential of a human or animal body and adapted to be worn on the body, including: at least two electrode sensors. Each of the at least two electrode sensors includes a first electrical contact configured to be in electrical contact with the skin of the body when the system is worn, and a second electrical contact. A single electrical connector electrically connects the at least two electrode sensors with each other via the second electrical contact. An active device is configured to cooperate with a subset of the at least two electrode sensors such that the potential of the electrical connector is substantially equal to a projected potential determined from the potential of the first electrical contact of each electrode sensor of the subset when the measurement device is worn. 
     SUMMARY OF THE INVENTION 
     The present invention relates to systems and methods including a device having integrated sensor arrays constructed and configured to measure and analyze multiple biosignatures concurrently in real time and a mobile application to control the device, process data, and transmit data wirelessly via at least one network to at least one remote computing device for analyzing the multiple biosignatures and cross-correlation with at least one external factor resulting in the creation of personal and situation profiles for continued on-going real time monitoring, refinement, alerting, and action recommendations. 
     In one embodiment, the present invention provides a system for using integrated sensor arrays to measure and analyze multiple biosignatures from a human or an animal including an apparatus for sensing and analyzing at least two biosignatures, wherein the apparatus includes a biosensor array, an electronic core, and at least one antenna, at least one remote transceiver device, and at least one remote computer server, wherein the biosensor array includes at least two sensors, wherein two or more of the at least two sensors are of differing modalities, wherein the electronic core includes a multiplexer, at least one analog-to-digital converter, and at least one processor, wherein the apparatus analyzes at least two biosignatures from the at least two sensors, calculates at least one output datum of the at least two biosignatures, and transmits the at least one output datum to the at least one remote transceiver device, wherein the at least one remote transceiver device transmits the at least one output datum to the at least one remote computer server or at least one remote computing device or database for storage, wherein the apparatus and the at least one remote transceiver device have real-time or near-real-time two-way communication, wherein the at least one remote transceiver device and the at least one remote computer server have real-time or near-real-time communication, and wherein the at least one remote computer server is operable to analyze apparatus data using cross-modal analytics. 
     In another embodiment, the present invention provides a system for using integrated sensor arrays to measure and analyze multiple biosignatures from a human or an animal including an apparatus for sensing and analyzing at least two biosignatures, wherein the apparatus includes a biosensor array, an electronic core, and at least one antenna, at least one remote transceiver device, and at least one remote computer server, wherein the biosensor array includes at least two sensors, wherein two or more of the at least two sensors are of differing modalities, wherein the electronic core includes a multiplexer, at least one analog-to-digital converter, and at least one processor, wherein the apparatus analyzes at least two biosignatures from the at least two sensors, calculates at least one output datum of the at least two biosignatures, and transmits the at least one output datum to the at least one remote transceiver device, wherein the at least one remote transceiver device transmits the at least one output datum to the at least one remote computer server or at least one remote computing device or database for storage, wherein the apparatus and the at least one remote transceiver device have real-time or near-real-time two-way communication, wherein the at least one remote transceiver device and the at least one remote computer server have real-time or near-real-time communication, wherein at least one external factor is stored on the at least one remote computer server, wherein the at least one remote computer server is operable to analyze apparatus data using cross-modal analytics, wherein the at least one remote computer server is operable to detect at least one biosignature change and at least one rate of change of the at least one biosignature change, wherein the at least one remote computer server is operable to generate at least one alert when the at least one biosignature change and the at least one rate of change of the at least one biosignature is greater than a designated threshold. 
     In yet another embodiment, the present invention includes a method for using integrated sensor arrays to measure and analyze multiple biosignatures from a human or an animal, the method including providing an apparatus for sensing and analyzing at least two biosignatures, wherein the apparatus includes at least two sensors, at least one analog-to-digital converter, a multiplexer, a processor, and at least one antenna, at least one remote transceiver device, and at least one remote computer server, wherein the at least one remote transceiver device and the apparatus are operable for two-way cross-communication in real time or near-real time, each of the at least two sensors sensing at least one biosignature of the human or the animal, the processor converting the at least one biosignature of the human or the animal into at least one output datum using at least one algorithm, one or more of the at least one antenna transmitting the at least one output datum to the at least one remote transceiver device via the two-way communication with the apparatus, the at least one remote transceiver device sharing or transmitting the at least one datum with the at least one remote computer server or at least one remote computing device or database for storage, and the at least one remote computer server analyzing apparatus data using cross-modal analytics. 
     These and other aspects of the present invention will become apparent to those skilled in the art after a reading of the following description of the preferred embodiment when considered with the drawings, as they support the claimed invention. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  illustrates a single modality sensor that evaluates one biosignature string. 
         FIG. 2  illustrates a block diagram of one embodiment of a device including multiple sensing modalities that target multiple human or animal characteristics with a single circuit to measure, process, store, and communicate data. 
         FIG. 3A  illustrates a top perspective view of one embodiment of a device. 
         FIG. 3B  illustrates a bottom perspective view of the device shown in  FIG. 3A . 
         FIG. 4A  illustrates a top perspective view of one embodiment of the invention as a wrist band. 
         FIG. 4B  illustrates a bottom perspective view of one embodiment of the invention as a wrist band. 
         FIG. 5  illustrates one embodiment of the invention as a wearable forearm sleeve. 
         FIG. 6A  illustrates one example of a user interface for a mobile application. 
         FIG. 6B  illustrates another example of a user interface for a mobile application. 
         FIG. 7A  is a quadrant diagram for estimating fluid and sodium replacement rates. 
         FIG. 7B  illustrates a graph of situation profiles for normal patients, pregnant patients, patients during delivery, and post-partum patients. 
         FIG. 8A  illustrates one embodiment of a system for cloud biosignature analytics. 
         FIG. 8B  illustrates a block diagram of an artificial intelligence engine for analyzing cross-modal analytics. 
         FIG. 9A  illustrates data from an electrochemical sensor with an ion selective electrode that yields a signal strength that corresponds to sodium ion concentration in sweat. 
         FIG. 9B  illustrates data from the electrochemical sensor in  FIG. 9A  calibrated using sympathetic nervous system activity. 
         FIG. 10  shows one embodiment of an assessment table of an early warning system monitoring abnormal bio-activity. 
         FIG. 11A  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to malaria. 
         FIG. 11B  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to myocardial infarction. 
         FIG. 11C  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to alcohol poisoning. 
         FIG. 11D  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to drug use and/or overdose. 
         FIG. 11E  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to diarrheal diseases. 
         FIG. 11F  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to a fight. 
         FIG. 11G  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to measles. 
         FIG. 11H  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to acute respiratory infections. 
         FIG. 11I  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to malnutrition. 
         FIG. 12  illustrates a core layout of an embodiment of the device including a flexible, replaceable sensor flap. 
         FIG. 13A  illustrates one embodiment of a microcontroller. 
         FIG. 13B  illustrates one embodiment of an accelerometer. 
         FIG. 13C  illustrates one embodiment of an integrated blood oxygen sensor and heart rate monitor. 
         FIG. 13D  illustrates one embodiment of a connector that connects debuggers, programmers, and test equipment to a PCB. 
         FIG. 13E  illustrates one embodiment of an NFC antenna connector. 
         FIG. 13F  illustrates one embodiment of pull up resistors connected to the microcontroller in  FIG. 13A . 
         FIG. 13G  illustrates one embodiment of a pull down resistor connected to the microcontroller in  FIG. 13A . 
         FIG. 14  illustrates a diagram of the system communications. 
         FIG. 15  illustrates one embodiment of the invention as a refugee care system. 
         FIG. 16  shows a diagram of the system architecture. 
         FIG. 17  shows a diagram of the network connection between the user mobile app and the user web service. 
         FIG. 18  shows a diagram of a system for public health monitoring and research analytics. 
         FIG. 19  illustrates a schematic diagram illustrating general components of a cloud-based computer system. 
     
    
    
     DETAILED DESCRIPTION 
     The present invention is generally directed to systems and methods including a device having integrated sensor arrays constructed and configured to measure and analyze inputs from sensors that provide multiple biosignatures in real time. The system includes a mobile application to control, process, and transmit data. The systems and methods are operable to transmit the inputs and/or data wirelessly via at least one communications network to a remote computing device for analyzing the multiple biosignatures, calculating data related to the multiple biosignatures, and storing the data in a database, on the remote computing device, and/or a remote computer server or cloud-based computing system. 
     In one embodiment, the present invention provides a system for using integrated sensor arrays to measure and analyze multiple biosignatures from a human or an animal including an apparatus for sensing and analyzing at least two biosignatures, wherein the apparatus includes a biosensor array, an electronic core, and at least one antenna, at least one remote transceiver device, and at least one remote computer server, wherein the biosensor array includes at least two sensors, wherein two or more of the at least two sensors are of differing modalities, wherein the electronic core includes a multiplexer, at least one analog-to-digital converter, and at least one processor, wherein the apparatus analyzes at least two biosignatures from the at least two sensors, calculates at least one output datum of the at least two biosignatures, and transmits the at least one output datum to the at least one remote transceiver device, wherein the at least one remote transceiver device transmits the at least one output datum to the at least one remote computer server or at least one remote computing device or database for storage, wherein the apparatus and the at least one remote transceiver device have real-time or near-real-time two-way communication, wherein the at least one remote transceiver device and the at least one remote computer server have real-time or near-real-time communication, and wherein the at least one remote computer server is operable to analyze apparatus data using cross-modal analytics. 
     In another embodiment, the present invention provides a system for using integrated sensor arrays to measure and analyze multiple biosignatures from a human or an animal including an apparatus for sensing and analyzing at least two biosignatures, wherein the apparatus includes a biosensor array, an electronic core, and at least one antenna, at least one remote transceiver device, and at least one remote computer server, wherein the biosensor array includes at least two sensors, wherein two or more of the at least two sensors are of differing modalities, wherein the electronic core includes a multiplexer, at least one analog-to-digital converter, and at least one processor, wherein the apparatus analyzes at least two biosignatures from the at least two sensors, calculates at least one output datum of the at least two biosignatures, and transmits the at least one output datum to the at least one remote transceiver device, wherein the at least one remote transceiver device transmits the at least one output datum to the at least one remote computer server or at least one remote computing device or database for storage, wherein the apparatus and the at least one remote transceiver device have real-time or near-real-time two-way communication, wherein the at least one remote transceiver device and the at least one remote computer server have real-time or near-real-time communication, wherein at least one external factor is stored on the at least one remote computer server, wherein the at least one remote computer server is operable to analyze apparatus data using cross-modal analytics, wherein the at least one remote computer server is operable to detect at least one biosignature change and at least one rate of change of the at least one biosignature change, wherein the at least one remote computer server is operable to generate at least one alert when the at least one biosignature change and the at least one rate of change of the at least one biosignature is greater than a designated threshold. 
     In yet another embodiment, the present invention includes a method for using integrated sensor arrays to measure and analyze multiple biosignatures from a human or an animal, the method including providing an apparatus for sensing and analyzing at least two biosignatures, wherein the apparatus includes at least two sensors, at least one analog-to-digital converter, a multiplexer, a processor, and at least one antenna, at least one remote transceiver device, and at least one remote computer server, wherein the at least one remote transceiver device and the apparatus are operable for two-way cross-communication in real time or near-real time, each of the at least two sensors sensing at least one biosignature of the human or the animal, the processor converting the at least one biosignature of the human or the animal into at least one output datum using at least one algorithm, one or more of the at least one antenna transmitting the at least one output datum to the at least one remote transceiver device via the two-way communication with the apparatus, the at least one remote transceiver device sharing or transmitting the at least one datum with the at least one remote computer server or at least one remote computing device or database for storage, and the at least one remote computer server analyzing apparatus data using cross-modal analytics. 
     Referring now to the drawings in general, the illustrations are for the purpose of describing a preferred embodiment of the invention and are not intended to limit the invention thereto. 
     Prior art sensors, as shown in  FIG. 1 , use only one type of sensor (e.g., image/photon, spectroscopy, electrochemical, inertial, thermal, radiofrequency (RF)) on a single target (e.g., sweat, skin, air, sound) and each sensor has its own circuit to measure, process, store, and communicate data. In the example shown in  FIG. 1 , a first sensor  110  of a first modality type has a first circuit  112  that includes a first analog-to-digital converter (ADC)  114 , a first microprocessor  115 , and a first transceiver  116 . Data is sent from the first transceiver  116  to a first cloud  118 . A second sensor  120  of a second modality type has a second circuit  122  that includes a second analog-to-digital converter (ADC)  124 , a second microprocessor  125 , and a second transceiver  126 . Data is sent from the second transceiver  126  to a second cloud  128 . A third sensor  130  of a third modality type has a third circuit  132  that includes a third analog-to-digital converter (ADC)  134 , a third microprocessor  135 , and a third transceiver  136 . Data is sent from the third transceiver  136  to a third cloud  138 . Data sent to the first cloud  118  is operable to be sent to the second cloud  128  and/or the third cloud  138 . Data sent to the second cloud  118  is operable to be sent to the first cloud  118  and/or the third cloud  138 . Data sent to the third cloud  118  is operable to be sent to the first cloud  118  and/or the second cloud  128 . 
     In other prior art cases, a circuit is designed to handle multiple sensors of a single type/modality (e.g., electrochemical sensors to analyze different analytes in sweat). In both prior art cases, the circuit is fine-tuned for a single modality and all signals are processed independently and analyzed independently. Data is stored, viewed, and/or displayed as separate biosensor data. None of the prior art includes multi-modal analytics. The prior art uses multiple devices to access the data using many independent applications for each single modality. This results in unconnected user functions and users are limited to results from a single modality. 
     Examples of prior art sensors include the following issued patents and/or publications for biological fluid sensors: U.S. Pat. Nos. 9,579,024, 9,622,725, 9,636,061, 9,645,133, and 9,883,827 and U.S. Publication Nos. 20160262667, 20160287148, and 20170223844, each of which is incorporated herein by reference in its entirety. 
     The present invention uses multiple sensors, modalities, and/or targets through a single circuit, in a single device, with cross-modal (X-Mod) analytics.  FIG. 2  illustrates a block diagram of one embodiment of a device  200  including multiple sensing modalities (e.g., image/photon, spectroscopy, electrochemical, inertial, thermal, RF, electromagnetic, ultrasound), that target multiple human or animal characteristics (e.g., skin temperature, sweat, tears, blood, urine, movement, pH, heart rate, blood oxygen levels) with a single circuit to measure, process, store, and communicate data. In one embodiment, the device  200  includes at least one environmental sensor to target environmental characteristics (e.g., temperature, air contaminants, sound) with the single circuit to measure, process, store, and communicate data. The device  200  includes at least two sensors  202  (e.g., four sensors  202 ) that form a biosensor array  204 . In one example, the device  200  includes a heart rate sensor, a blood oxygen sensor, an accelerometer, and a temperature sensor. The device  200  includes an electronic core  206  that includes a multiplexer  208 , at least one analog-to-digital converter (ADC)  210 , and a microprocessor  212 . The device  200  includes a flexible, replaceable communications flap  214  connected to the electronic core  206 . The flexible, replaceable communications flap  214  includes at least one transceiver  216  that is operable to provide wireless network communication with at least one remote transceiver device  230 . In one embodiment, the at least one transceiver  216  includes a coil, a radio frequency (RF) antenna, and/or a BLUETOOTH transceiver module. 
     In a preferred embodiment, the device  200  is controlled and configured (e.g., sample rate, sample frequency, sample instructions, processing instructions) via at least one remote transceiver device  230  (e.g., smartphone, tablet, laptop computer, desktop computer) with a user interface. The user interface is preferably a mobile application. The at least one remote transceiver device  230  is operable to process the data and send the data to an aggregated data cloud  240 . The aggregated data cloud  240  is operable to further process the data and provide analytics. In one embodiment, the data is aggregated into a single cloud for linear modal processing of each modality. In another embodiment, the single cloud uses X-Mod analytics, which are cross-modal analytics that include change detection, rates, vectors, cross queues, tips, condition settings, user settings, self-calibrations, trends, patterns, validations, and/or alerts. Performance of the at least two sensors  202  is improved through active integration of the at least two sensors  202  into an array that is then processed, analyzed, stored, and accessed through a single system consisting of a measurement circuit, a mobile application, and a cloud database. The single circuit is designed for multiple sensors, signals, and sensitivities across many modalities. The single circuit isolates many different signals, filters noise, and mitigates interference across the modalities on the single circuit with highly complex firmware to handle each sensor read, sample rate, data scheme, storage, and other similar control commands. The aggregated data cloud  240  includes external factors  250 , such as clinical observations, eyewitness data, offline analytics, laboratory test results, weather, social media analytics, external research, and web data. The analytics draw across all modalities and external information in the cloud  240 . 
       FIG. 3A  illustrates a top perspective view of one embodiment of a device  300 . The device  300  has an electronic core  302 . In one embodiment, the electronic core  302  is formed of a polyimide substrate (e.g., Kapton®). The electronic core  302  is preferably flexible. In a preferred embodiment, the electronic core  302  includes at least one data port  304  (e.g., USB, micro-USB). The at least one data port  304  is preferably operable to recharge the at least one battery  310  via a cable connected to an alternating current (AC) power source. Additionally, a flexible, replaceable communications flap  306  is connected to the electronic core  302 . In one embodiment, the flexible, replaceable communications flap  306  is formed of a polyimide substrate (e.g., Kapton®). The flexible, replaceable communications flap  306  includes at least one transceiver antenna  308  that is operable to provide wireless network communication with at least one remote transceiver device. In one embodiment, the at least one transceiver antenna  308  includes a coil. In an alternative embodiment, the at least one transceiver antenna  308  includes a radio frequency (RF) antenna. The at least one transceiver antenna  308  is connected to the electronic core  302  via an NFC connector  310 . Additionally, or alternatively, the device includes at least one transceiver on the electronic core. The device  300  includes at least one battery  312  operable to power the device  300 . In a preferred embodiment, the at least one battery  312  is a pouch type lithium-ion polymer battery. In one embodiment, the at least one battery  312  is a pouch type lithium-ion polymer battery, model FLPB352030 by Routejade. Alternative batteries are compatible with the present invention. 
       FIG. 3B  illustrates a bottom perspective view of the device shown in  FIG. 3A . The electronic core  302  includes at least one multiplexer  314 , at least one analog-to-digital converter  316 , and at least one processor  318 . The at least one processor  318  may be a general-purpose microprocessor (e.g., a central processing unit (CPU)), a graphics processing unit (GPU), a microcontroller, a Digital Signal Processor (DSP), an Application Specific Integrated Circuit (ASIC), a Field Programmable Gate Array (FPGA), a Programmable Logic Device (PLD), a controller, a state machine, gated or transistor logic, discrete hardware components, or any other suitable entity or combinations thereof that can perform calculations, process instructions for execution, and/or other manipulations of information. The electronic core  302  also includes an integrated blood oxygen sensor and heart rate monitor  320 . 
     In another embodiment, the electronic core includes at least one memory. In one embodiment, the at least one memory is RAM, ROM, EPROM, EEPROM, and/or FLASH memory. In another embodiment, one or more of the at least one memory is incorporated into the at least one processor. In yet another embodiment, one or more of the at least one memory is operable to store raw data obtained by the device and/or at least one output datum calculated by the device. 
     In another embodiment, the electronic core includes at least one light emitting diode (LED). In one embodiment, the at least one LED is a tri-color LED. In one example, the tri-color LED is a red, green, and blue (RGB) LED. Advantageously, the RGB LED allows for color mixing, which allows for a greater number of colors from a single LED. One or more of the at least one LED is preferably operable to provide alerts based on analyzed data. In one example, an LED begins flashing (e.g., red flashing) when the analyzed data indicates that a user may experience an adverse event (e.g., heart attack) in the near future. In yet another embodiment, one or more of the at least one LED is operable to provide an indication of battery status. In one example, an LED begins flashing (e.g., white flashing) when the battery needs to be charged. In still another embodiment, one or more of the at least one LED is operable to provide an indication of the at least one memory status. In one example, an LED begins flashing (e.g., yellow flashing) when the at least one memory is almost full. This prompts the user to visit a scanner to refresh the at least one memory. 
     The device includes a sweat sensor, at least one temperature sensor, a pH sensor, a heart rate sensor, a blood oxygen sensor (e.g., a pulse oximetry sensor), an accelerometer, a glucose sensor, and/or at least one sympathetic nervous system (stress) sensor. In one embodiment, the sweat sensor measures a concentration of sodium in sweat and a concentration of potassium in sweat. The device is preferably operable to measure a concentration ratio of sodium to potassium, which provides an estimate of fluid losses (e.g., through sweat). The at least one temperature sensor is operable to measure skin temperature, core temperature, and/or ambient temperature. The accelerometer is operable to measure impact, shivering, seizures, and/or any other similar body movements. The blood oxygen sensor measures peripheral capillary oxygen saturation (SpO2). In one embodiment, the blood oxygen sensor is used in combination with an accelerometer measuring respiratory rates to produce sweat loss estimates using X-Mod analytics, which calibrates and/or validates prior readings from the sodium sensor and/or the potassium sensor. The at least one sympathetic nervous system (SNS) sensor is operable to measure cardio stress, pulmonary blood oxygen stress, physical stress, gastro stress, thermoregulation stress, glucose stress, arterial stress, and/or acid stress. In a preferred embodiment, the SNS sensor is non-invasive and uses at least one electrocardiogram (ECG) pad. In one embodiment, the SNS sensor is used to calibrate and/or validate other sensors. In a preferred embodiment, the glucose sensor is non-invasive and measures RF changes in the skin. The stabilized antibodies sensors detect the presence of designated antigens and other signs of bacterial and/or viral infections. In a preferred embodiment, viral sensors and/or bacterial sensors utilize antibodies stabilized through ionic fluid. This extends the shelf life of the viral sensors and/or the bacterial sensors under ambient/non-cooled storage conditions. The antibodies are used to detect antigens for designated infections using immunoassays and/or redox cells. In one embodiment, the assay results are presented as a binary true or false reading. A positive result indicating the presence of a target antigen is preferably represented visually (e.g., a color change to blue). Alternatively, the presence of a target antigen is indicated through voltage changes in a redox cell. In one embodiment, infection detection is further validated with detection signals from at least one electromagnetic sensor on the device. The at least one electromagnetic sensor is operable to detect at least one designated infection in the blood that carries a magnetic charge. In another embodiment, the device includes an analyte sensor to detect an analyte (e.g., hormones, electrolytes, small molecules (molecular weight &lt;900 Daltons), proteins, metabolites). The device also includes modular communications (e.g., NEAR FIELD COMMUNICATION (NFC), BLUETOOTH, WI-FI, ZIGBEE). 
     As previously described, the at least one SNS sensor preferably uses at least one ECG pad. The at least one ECG pad is placed on a wrist, an upper arm, a chest, a back, a finger, a neck, or other designated location on a user. The at least one SNS sensor detects and processes sympathetic nerve system activity (SNSA). In one embodiment, changes in SNSA are correlated with known conditions, data from at least one other sensor, and external factors (e.g., clinical observations). The system is operable to distinguish between cardio stress, pulmonary blood oxygen stress, physical stress, gastro stress, thermoregulation stress, glucose stress, arterial stress, and/or acid stress via signal characterization (e.g., signal gain rate, signal amplitude shape, signal decline, signal phase shifts). 
       FIG. 4A  illustrates a top perspective view of one embodiment of the invention as a wrist band. In one embodiment, the wrist band  400  is formed of neoprene. In another embodiment, the wrist band  400  houses the device from  FIGS. 3A-3B . The wrist band  400  includes a first strap  402  and a second strap  404  with a piece of hook tape  406 . A center pouch  406  is operable to hold the electronic core. The first strap  402  and the second strap  404  are affixed to the center pouch  410 . In one embodiment, the center pouch  406  is secured using at least one snap, hook and loop tape, at least one tie, at least one magnetic closure, at least one clasp, at least one hole, at least one tab, at least one cord lock, and/or at least one buckle. 
       FIG. 4B  illustrates a bottom perspective view of one embodiment of the invention as a wrist band. The first strap  402  includes a piece of loop tape  410 . The piece of hook tape  406  and the piece of loop tape  410  are operable to secure the wrist band  400  to a wearer&#39;s wrist. Alternatively, the wrist band is operable to be secured to the wearer&#39;s wrist using at least one magnetic closure, at least one snap, at least one clasp, at least one tie, at least one hole, at least one tab, at least one cord lock, and/or at least one buckle. The center pouch  410  includes at least one opening  412  operable to allow at least one sensor to rest against the wearer&#39;s skin. In one example, the at least one sensor is an integrated blood oxygen sensor and heart rate monitor. In one embodiment, the center pouch  410  has an opening that is secured using hook and loop tape, at least one magnetic closure, at least one snap, at least one clasp, at least one tie, at least one hole, at least one tab, at least one cord lock. and/or at least one buckle. In another embodiment, the first strap and/or the second strap includes a pocket for the flexible, replaceable communications flap. 
     The device is operable to be charged using proximity charging with a wrist band pad. In a preferred embodiment, the proximity charging utilizes far-field technology that converts radio frequency (RF) energy into direct current (DC) power. In another embodiment, the wrist band includes a removeable power cable to recharge via an alternating current (AC) source. 
     In another embodiment, the device includes at least one medical textile. In one example, the device includes a top layer formed of a medical textile (e.g., 3M™ 9926T Tan Tricot Fabric Medical Tape), a bottom layer formed of a double-sided adhesive (e.g., 3M™ 9917 Medical Nonwoven Tape), and an electronic core positioned between the top layer and the bottom layer. The top layer formed of the medical textile includes an adhesive layer that is attached to a top side of the electronic core. The bottom layer formed of the double-sided adhesive is attached on a first side to a bottom side of the electronic core and intimately adhered on a second side to the skin of the wearer. In another example, the device includes a top layer formed of a medical textile (e.g., 3M™ 9926T Tan Tricot Fabric Medical Tape), a bottom layer formed of the medical textile (e.g., 3M™ 9926T Tan Tricot Fabric Medical Tape), and an electronic core positioned between the top layer and the bottom layer. The top layer formed of the medical textile includes an adhesive layer that is attached to a top side of the electronic core and the bottom layer formed of the medical textile includes an adhesive layer that is attached to a bottom side of the electronic core. In one embodiment, the top layer and/or the bottom layer includes at least one opening for a sensor, an LED, and/or other electronic components. In yet another embodiment, the device includes a transceiver antenna flap with a top layer formed of a medical textile (e.g., 3M™ 9926T Tan Tricot Fabric Medical Tape), a bottom layer formed of the medical textile (e.g., 3M™ 9926T Tan Tricot Fabric Medical Tape), and a transceiver antenna coil between the top layer and the bottom layer. Advantageously, this provides additional protection to the transceiver antenna coil. In one embodiment, the device is secured to the wearer using hook and loop tape, at least one magnetic closure, at least one snap, at least one clasp, at least one tie, at least one hole, at least one tab, at least one cord lock, and/or at least one buckle. 
       FIG. 5  illustrates one embodiment of the invention as a wearable forearm sleeve  500 . In a preferred embodiment, the wearable forearm sleeve  500  is formed of neoprene and/or elastic. In one embodiment, the wearable forearm sleeve  500  is available in multiple sizes to accommodate different arm sizes (e.g., small, medium, large, child, infant). The wearable forearm sleeve  500  includes an antenna  502 , flexible electronics  504  integrated into the sleeve, and a disposable sensor head  506 . In one embodiment, the flexible electronics  504  include a multiplexer (MUX), at least one analog-to-digital converter (ADC), microprocessor (uP), a sensor array, GPS, and/or modular communications (e.g., WI-FI, WORLDWIDE INTEROPERABILITY FOR MICROWAVE ACCESS (WIMAX), Radio Frequency (RF) communication including RE identification (RFID), NEAR FIELD COMMUNICATION (NFC), BLUETOOTH including BLUETOOTH LOW ENERGY (BLE), ZIGBEE, Infrared (IR) communication, cellular communication, satellite communication). In one embodiment, the sensor array includes a heart rate sensor, a blood oxygen sensor, a blood pressure sensor, an accelerometer, at least one temperature sensor, and/or a glucose sensor. The blood pressure sensor is an optical sensor in one embodiment. The disposable sensor head  506  includes at least one disposable sensor patch. In one embodiment, the at least one disposable sensor patch includes a sweat sensor, a sympathetic nervous system (SNS) sensor, a stabilized antibodies sensor (e.g., viral sensor, bacterial sensor), and/or a pH sensor. In a preferred embodiment, the device includes a power status indicator  508  that is visible on the exterior of the forearm sleeve. The device includes a sensor align button  510 , which ensures that the connection between the sensor head and electronics in the sleeve are aligned and signals can flow, which is confirmed through a self-test of the microprocessor. 
     The wearable forearm sleeve  500  is operable to be charged using proximity charging with a sleeve recharging cone  520 . In a preferred embodiment, the proximity charging utilizes far-field technology that converts radio frequency (RF) energy into direct current (DC) power. In one embodiment, the sleeve recharging cone  520  includes charging tabs  522  for contact charging as an alternative to proximity charging. 
     As previously described, the device includes a biosensor array. The device has a single multiplexer that pulls in signals from all of the sensors and all of the modalities. The signals flow through a series of capacitors and resistors to properly condition the signals, which are then converted using an ADC with a programmable amplifier. The amplifier gain is customized to reach designated thresholds for each sensor signal type, without over gain. The ADC signals are passed to the microprocessor for processing and converting, and then to storage in one or more of the at least one memory. The microprocessor manages read times, gains, processing, and store instructions. Data in storage is extracted via a communications event (e.g., NFC scan, BLUETOOTH read, burst). 
     A first source of data is the biosensor array, which is operable to sense multiple targets (e.g., sweat, urine, blood, skin, air, sound) using multiple modalities (e.g., imaging, spectroscopy, electrochemical, thermal). The integrated sensor array uses one circuit to measure, process, and store data. The circuit is designed for multiple sensors, signals, and sensitivities across many modalities. The single circuit isolates many different signals, filters noise, and mitigates interference across the modalities on the single circuit with highly complex firmware. A second source of data is external information, such as clinical observations, eyewitness data, offline analytics, laboratory test results, and web data. The data is aggregated into a single data cloud for linear modal processing of each modality. Cross modal analytics (X-Mod) include cross queues, tips, condition settings, user settings, self-calibrations, personalization, trends, patterns, validation of the data, and/or alerts based on the data. This results in a personal profile and situation profiles that are monitored and compared to an existing profile for a user and common demographic populations or other groups of common interest and/or attributes. Examples of groups of common interest and/or attributes include, but are not limited to, pregnancy, maternal delivery, cancer detection, cancer treatment, drug therapies, military special operations, emergency service personnel (e.g., fire, rescue, police), and athletes (e.g., race car drivers, football players, marathon runners). 
     One example of personalization is adjusting a blood pressure range based on patient history and/or conditions. For example, a blood pressure of 144/95 mmHg is deemed normal for a patient when the patient&#39;s blood sugar is under 200 mg/dL and an alert condition is set when the systolic blood pressure is above 150 when the patient&#39;s blood sugar is above 225 mg/dL. Advantageously, the personal profile is operable to adjust a baseline and at least one alert threshold, which prevents the system from needlessly alerting health and/or aid workers for conditions normal for a particular patient. 
     In a preferred embodiment, a mobile application on at least one remote transceiver device provides visibility to raw data and/or X-Mod analytics. The mobile application preferably is operable to provide an alert, a notification, and/or an acknowledgement. In one embodiment, the mobile application is operable to forward an alert, a notification, and/or an acknowledgement to another user. In one example, an alert regarding a patient is sent to a healthcare provider or a caregiver. In another example, a patient sends an acknowledgement after a healthcare provider makes a modification to a protocol (e.g., modification of insulin dosage, timing of medication). The mobile application preferably aligns information from the ISA with advisor prescribed information to recommend an action to a user. 
     In one embodiment, the mobile application provides a record and/or a timestamp for when a user completes an action (e.g., takes a medication). Additionally, or alternatively, the mobile application allows a user to mark an action as complete. In another embodiment, the mobile application allows a user to mark an action as delayed. The mobile application preferably resends a notification to remind the user to complete the delayed action. 
     In one embodiment, the mobile application includes at least one scheduled advisory action (e.g., dietary, exercise, medication) for a patient. A medication scheduled advisory action includes a name of a prescription, a dosage of the prescription (e.g., volume, weight), a prescription number, a production identification, and/or a picture reminder. In a preferred embodiment, the mobile application coordinates re-ordering consumables (e.g., medication, bandages). The mobile application preferably checks for potential drug interactions. In another embodiment, the mobile application advises a user of expectations and/or possible side effects based on a medication prescribed and/or a location. The mobile application interacts with healthcare providers (e.g., doctors, nurses, in-home health care), caregivers, hospice, and/or emergency services (e.g., paramedics, police, fire, first responders). In one embodiment, the mobile application is operable to be programmed for areas of concern, special medical treatment, and/or allergies. In another embodiment, the mobile application is operable to follow an escalation process of communication and alerts defined by a user and/or an advisor (e.g., healthcare provider). 
     In one embodiment, the mobile application records a time and a unit related to food (e.g., type, weight, calories, macros) and/or drink (e.g., by volume) consumed. The mobile application preferably records a physical activity of the user. In one embodiment, the physical activity of the user is measured by the accelerometer. In another embodiment, the mobile application records environmental parameters (e.g., temperature, humidity) of a location of the user. 
     In one embodiment, more than one mobile application is used to provide additional layers of security. In one example, a user has access to all health data of the user through a first mobile application, while the health data is inaccessible to a worker employed to read or scan sensor outputs through a second mobile application. Alternatively, the mobile application provides several account types. In one example, the mobile application includes a user (e.g., patient) account type, an employee (e.g., scanner) account type, a humanitarian (e.g., Red Cross) account type, and a healthcare provider (e.g., doctor, nurse) account type. In another example, authentication and/or encryption is used to provide for select user or restricted access to the health data of the individual. 
       FIG. 6A  illustrates one example of a user interface for a mobile application. The mobile application is accessible from a smartphone or tablet. Alternatively, or additionally, the mobile application is accessible on any portable (e.g., laptop computer) or desktop device via a cloud web application. The mobile application is operable to run on a single device or a plurality of devices concurrently. In one embodiment, the data can be accessed through a single mobile application. The mobile application sets configurations, processes data, transmits data, and retrieves data from the cloud, and presents data to users in a personalized graphical display. The mobile application is a multi-resource analyzer and assistant. The mobile application reminds users to take pre-determined actions or advisor actions resulting from real time data, profiles, and/or alerts. Advisors augment actions with detailed descriptions, such as a reminder to take a prescribed medicine including an amount and type of medication (e.g., pill). Using a reminder system, the mobile application is operable to track when the user completed an action and monitor how the action affects the user&#39;s profile. The mobile application uses data analytics to determine if the user is in a condition where an action needs to be taken to optimize at least one goal (e.g., wellness, performance) or minimize at least one risk. The mobile application detects when a user is unresponsive based on cross-modality change detections (e.g., no movement, low respiratory rate, low pulse) and is operable to trigger an automatic message to a user defined contact list or an emergency response service. 
     In the example shown in  FIG. 6A , the user interface includes an identification number (W-Id), a birth year, a gender, a height, a weight, and a time of a last scan of a user. The user interface indicates whether the device is on or off. Additionally, the user interface displays a battery level. In this example, the battery level is low and the user interface displays a warning to replace the device. The user interface displays if any patterns are recognized based on the ISA data and/or the X-FAX. In this example, the user interface displays warnings for cholera, malnutrition, and unconsciousness. A temperature graph is shown on the user interface. The user interface is operable to display a motion graph. 
       FIG. 6B  illustrates another example of a user interface for a mobile application. In the example shown in  FIG. 6B , the user interface displays a pH graph, a heart rate graph, and a blood oxygen level graph. 
       FIG. 7A  is a quadrant diagram for estimating fluid and sodium replacement rates from Taylor et al., Regional variations in transepidermal water loss, eccrine sweat gland density, sweat secretion rates and electrolyte composition in resting and exercising humans, published in Extreme Physiology &amp; Medicine, 2013; 2:4, doi:10.1186/2046-7648-2-4, which is incorporated herein by reference in its entirety. As shown in  FIG. 7A , oxygen consumption increases linearly with increases in heart rate due to exercise. Therefore, starting with the heart rate (labeled “1” in the figure), an oxygen consumption is approximated (labeled “2” in the figure). Additionally, core body temperature is linked to oxygen consumption. Thus, the core body temperature is approximated (labeled “3” in the figure). Sweat rate increases asymptotically relative to core temperature. Therefore, the sweat rate is approximated (labeled “4” in the figure). Finally, sweat sodium secretion is a positive linear function of sweat rate, allowing for an approximation of the sweat sodium secretion (labeled “5” in the figure) and fluid replacement rates (labeled “6” in the figure) required to maintain body-fluid and electrolyte homeostasis. 
     As previously described, the present invention utilizes X-Mod schemes to improve accuracy via multi-source calibration and validation. X-Mod analytics use changes in multiple sensor streams and create profiles based on change rates, change vectors, change trends, and/or change patterns. A collection of changes that represent a normal day for an individual is called a personal profile. Similarly, a set of changes that characterize a unique situation for a group and/or demographic of a population all under a similar situation (e.g., pregnancy, cancer, concussion) is called a situation profile. Personal profiles and situation profiles are compared to real time biosignature change activity in a user to detect anomalies, concerns, and/or general items of interest. 
       FIG. 7B  illustrates a graph of situation profiles for normal patients, pregnant patients, patients during delivery, and post-partum patients. In the example shown in  FIG. 7B , a deviation of a patient from the situation profile for patients during delivery is shown with a dotted line. This deviation from the situation profile triggers an alert condition, allowing for closer supervision of the patient and/or medical intervention. 
     For the cross-modal (X-Mod) analysis, the following algorithm is used to determine a change in biosignature (dBioSig): 
         d BioSig= dS 1+ dS 2+ dS 3+ . . . + dSn    
     where dS is a biosensor change over a period of time (T). The biosensor change over the period of time (dS) is a function of a magnitude/scaling factor (m), sensor dependent variables (dSV), and time dependent variables (dTV). 
     One example of a change in biosignature is shown in the following equation: 
     
       
         
           
             dContraction 
             = 
             
               
                 
                   0.32 
                   × 
                   
                     f 
                      
                     
                       ( 
                       dHR 
                       ) 
                     
                   
                 
                 + 
                 
                   f 
                    
                   
                     ( 
                     
                       dO 
                        
                       
                           
                       
                        
                       2 
                     
                     ) 
                   
                 
                 + 
                 
                   f 
                    
                   
                     ( 
                     dAccel 
                     ) 
                   
                 
               
               
                 
                   f 
                    
                   
                     ( 
                     dTemp 
                     ) 
                   
                 
                 + 
                 
                   f 
                    
                   
                     ( 
                     dSLR 
                     ) 
                   
                 
               
             
           
         
       
     
     where dHR is a change in heart rate over a period of time, dO2 is a change in blood oxygen level over the period of time, dAccel is a change in acceleration over the period of time, dTemp is a change in body temperature over the period of time, and dSLR is a change in sodium loss rate over the period of time. 
       FIG. 8A  illustrates one embodiment of a system for cloud biosignature analytics. Data from sensors and external factors are used to create biosignatures. A biosignature is a collection of biomarker changes (deltas) over time. In the example shown in  FIG. 8A , biosignatures are shown for heart rate (dHR), body temperature (dT° F.), blood oxygen level (dSpO2), pH (dpH), and SNS activity (dSNS). The biosignature data is compared to personal profiles and situation profiles to determine if there is a deviation from an expected profile. In the example shown in  FIG. 8A , deviations from the situation profile are shown for heart rate, body temperature, and SNS activity with the dashed lines. These deviations would trigger an alert, resulting in closer supervision of the patient and/or medical intervention. 
     The X-Mod analytics are transmitted to an artificial intelligence (AI) engine to analyze the X-Mod analytics as shown in  FIG. 8B . The A engine examines the X-Mod analytics for trends and/or patterns. Further, the AI engine incorporates external research and is operable to perform text searches and/or scrapes of the external research. The trends and/or patterns and the text searches and/or scrapes of the external research are sent to a symbolic repository. Logic tests are performed on the data in the symbolic repository and then the results of the logic tests are validated. The validated results are used to perform sensor and analytics configuration management, which enhances accuracy of data results. The AI engine also incorporates field trials and/or subject matter experts to further analyze the X-Mod analytics. 
       FIGS. 9A-9B  illustrates the improvements in accuracy due to integrated sensor arrays.  FIG. 9A  illustrates data from an electrochemical sensor with an ion selective electrode (ISE) that yields a signal strength that corresponds to sodium ion concentration in sweat, which is in turn an indicator of instantaneous local sweat rate. If calibrated, the ISE signal can reflect real-time sweat loss (fluid) and sodium (electrolyte) loss. When tracked over time, the signal can help athletes know how much fluid and electrolytes have been lost and need to be replenished to maintain or optimize performance. 
     However, calibrating a signal to determine sweat (fluid) loss is difficult because a human body is very adaptable to stress. When stressed by ambient temperature, humidity, and other similar factors, sodium secretion into sweat is conserved, resulting in a much higher sweat rate (fluid loss) at a given sodium concentration in order to accelerate cooling. Additionally, variations in conditioning level (VO 2  max) further complicate the calibration, and introduce additional variability into the results. Consequently, external factors (e.g., heat, humidity) and conditioning induced stress will cause the sweat/sodium relationship curve to shift, meaning sodium is conserved so sweat volume actually increases with lower sodium concentration. This results in an incorrect original signal calibration. Many factors influence human sweat rate, which is a dynamic human body phenomenon that is difficult to model through software alone. 
     One method of measuring human physiological stress is by monitoring the human sympathetic nervous system (SNS). Sympathetic nervous system activity (SNSA) signals control physiological response to stress (fight or flight response), including the thermal regulation system (sweat glands). As a result, SNS signals are an ideal means to better calibrate an ISE sweat sensor signal as shown in the graph in  FIG. 9B . 
       FIG. 10  shows one embodiment of an assessment table of an early warning system monitoring abnormal bio-activity. At least one algorithm uses a combination of biosignature change thresholds to detect various concerns. In a preferred embodiment, the rate of change determines the severity of the concern. The combination of at least one biosignature change and at least one rate of change of the at least one biosignature change triggers an alert. In a preferred embodiment, the alert is assigned a severity level (e.g., caution, alert, critical) based on the rate of change. In one embodiment, the severity level is assigned a color code (e.g., caution is assigned a yellow color, alert is assigned an orange color, and critical is assigned a red color). For example, a 25% change per minute in heart rate (dHR) is assigned a caution level (e.g., yellow color), a 50% change per minute in heart rate (dHR) is assigned an alert level (e.g., orange color), and a 75% change per minute in heart rate (dHR) is assigned a critical level (e.g., red color). The color-coded alerts allow users to manage massive, complex, and interrelated biosignatures for a plurality of individuals, by providing continual real-time situational awareness derived from the sensors and the cross-modality based alerts. 
       FIG. 11A  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to malaria. In one example, the device includes a heart rate sensor, a blood oxygen sensor, a blood pressure sensor, at least one SNS sensor, a stabilized antibodies sensor, a skin temperature sensor, a sodium sensor, a potassium sensor, a glucose sensor, a pH sensor, and/or an accelerometer. A heart rate sensor detects an increase in heart rate over a 1-2 day period due to a decrease in effective circulating volume (ECF). A blood oxygen sensor detects a normal blood oxygen level. A blood pressure sensor detects a decrease in blood pressure due to lower ECF. At least one SNS sensor detects an increase in at least one stress level (e.g., cardio stress, pulmonary blood oxygen stress, physical stress, gastro stress, thermoregulation stress, glucose stress, arterial stress, acid stress). A stabilized antibodies sensor detects a target antigen. In one embodiment, the device indicates a color change to blue to indicate the presence of the target antigen. A skin temperature sensor detects a decrease in skin temperature over several days as the body increases vasoconstriction and decreases sweat production in an attempt to maintain homeostasis. A sodium sensor detects an increase in sodium loss. A potassium sensor detects an increase in potassium loss. An accelerometer detects no significant diagnostic information early in the disease state. However, lethargy and decreases movement are likely to present if the patient is not treated. Clinical observations may include lethargy, loose stools, poor per os (PO) intake, and/or blood in the stools. Social media analytics are patient dependent. 
       FIG. 11B  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to myocardial infarction. In one example, the device includes a heart rate sensor, a blood oxygen sensor, a blood pressure sensor, at least one SNS sensor, a stabilized antibodies sensor, a skin temperature sensor, a sodium sensor, a potassium sensor, a glucose sensor, a pH sensor, and/or an accelerometer. A heart rate sensor detects an increase in heart rate due to pain, decreased cardiac output leading to a compensatory increase in heart rate, and a generation of arrhythmias depending on where the coronary occlusion has occurred. Occasionally, the heart rate sensor detects a decrease in heart rate due to specific conditions (e.g., sinoatrial (SA) ischemia, Bezold-Jarisch syndrome). A blood oxygen sensor generally detects a normal blood oxygen level. The blood oxygen sensor may detect a lower blood oxygen if there is a massive myocardial infarction (MI) leading to poor cardiac output and acute heart failure. A blood pressure sensor may detect an increase in blood pressure or a decrease in blood pressure. An acute MI can cause sympathetic stimulation leading to an increase in heart rate and, thus, an increase in blood pressure. Blood pressure is generally slightly lower than normal because cardiac output is usually lower than normal after a heart attack. At least one SNS sensor detects an increase in cardio stress. A skin temperature sensor detects a normal skin temperature or a slightly lower skin temperature. In cases where the skin temperature of distal extremities is noticeably decreased, this could be an indicator of cardiogenic shock and is an ominous sign. A sodium sensor detects a decrease in sodium levels during an acute myocardial infarction. Sodium levels remain low on day 1 and returns to normal by day 4. Improvement in serum sodium indicates better clinical outcomes. Studies assume this is due to increased permeability of the sarcolemma. A potassium sensor detects a decrease in potassium levels during an acute myocardial infarction. Potassium levels usually return to normal by day 3. Hypokalemia might be due to increased circulating catecholamines during and after an acute myocardial infarction. A pH sensor detects a normal pH or an abnormal pH depending on whether the heart is able to maintain distal perfusion. An accelerometer detects no significant diagnostic information. Clinical observations may include pain that radiates to the jaw, between the shoulder blades or on the back, and/or down the left arm. Patients sometimes complain of chest pressure or a burning sensation. Social media analytics may include the patient reporting a feeling of unwellness over several days. 
       FIG. 11C  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to alcohol poisoning. In one example, the device includes a heart rate sensor, a blood oxygen sensor, a blood pressure sensor, at least one SNS sensor, a stabilized antibodies sensor, a skin temperature sensor, a sodium sensor, a potassium sensor, a glucose sensor, a pH sensor, and/or an accelerometer. Changes in heart rate detected by a heart rate sensor due to drug use and/or overdose are drug dependent. For example, opioids (e.g., heroin) cause bradycardia in high doses. Sympathomimetics (e.g., phencyclidine (PCP), methamphetamine, cocaine) increase heart rate until the drug is metabolized, which is usually occurs in a time course of hours. A blood oxygen sensor detects a decreased blood oxygenation in opioid-like drugs. Changes in blood pressure detected by a blood pressure sensor are variable depending on co-morbid conditions with drug use (e.g., hydration status, energy status, cardiac function). For example, sympathomimetics (e.g., cocaine) generally increase blood pressure for several hours. The half-life of cocaine with normal liver and function is 60 minutes. A SNS sensor detects an increase in gastro stress and/or arterial stress. Changes in skin temperature, sodium level, potassium level, glucose level, and pH as detected by a skin temperature sensor, a sodium sensor, a potassium sensor, a glucose sensor, and a pH sensor, respectively, are variable. Changes in acceleration as detected by an accelerometer are variable depending on drug intake. Drugs that cause limbic dissociation (e.g., PCP) and/or sympathomimetics (e.g., methamphetamine) may cause changes in acceleration. Further, patients may exhibit increased motor movement due to hallucinations and/or rage. Clinical observations may include decreased check ins due to drug use or addiction, poor activities of daily living, a disheveled appearance, signs of intoxication (e.g., rage), inability to sustain a conversation, and/or poorly coordinated motor function. Social media analytics are variable. 
       FIG. 11D  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to drug use and/or overdose. In one example, the device includes a heart rate sensor, a blood oxygen sensor, a blood pressure sensor, at least one SNS sensor, a stabilized antibodies sensor, a skin temperature sensor, a sodium sensor, a potassium sensor, a glucose sensor, a pH sensor, and/or an accelerometer. Changes in heart rate detected by a heart rate sensor due to drug use and/or overdose are drug dependent. For example, opioids (e.g., heroin) cause bradycardia in high doses. Sympathomimetics (e.g., phencyclidine (PCP), methamphetamine, cocaine) increase heart rate until the drug is metabolized, which is usually occurs in a time course of hours. A blood oxygen sensor detects a decreased blood oxygenation in opioid-like drugs. Changes in blood pressure detected by a blood pressure sensor are variable depending on co-morbid conditions with drug use (e.g., hydration status, energy status, cardiac function). For example, sympathomimetics (e.g., cocaine) generally increase blood pressure for several hours. The half-life of cocaine with normal liver and function is 60 minutes. A SNS sensor detects an increase in gastro stress and/or arterial stress. Changes in skin temperature, sodium level, potassium level, glucose level, and pH as detected by a skin temperature sensor, a sodium sensor, a potassium sensor, a glucose sensor, and a pH sensor, respectively, are variable. Changes in acceleration as detected by an accelerometer are variable depending on drug intake. Drugs that cause limbic dissociation (e.g., PCP) and/or sympathomimetics (e.g., methamphetamine) may cause changes in acceleration. Further, patients may exhibit increased motor movement due to hallucinations and/or rage. Clinical observations may include decreased check ins due to drug use or addiction, poor activities of daily living, a disheveled appearance, signs of intoxication (e.g., rage), inability to sustain a conversation, and/or poorly coordinated motor function. Social media analytics are variable. 
       FIG. 11E  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to diarrheal diseases. In one example, the device includes a heart rate sensor, a blood oxygen sensor, a blood pressure sensor, at least one SNS sensor, a stabilized antibodies sensor, a skin temperature sensor, a sodium sensor, a potassium sensor, a glucose sensor, a pH sensor, and/or an accelerometer. A heart rate sensor detects an increase in heart rate over a 1-2 day period due to a decrease in effective circulating volume (ECF). A blood oxygen sensor detects a normal blood oxygen level. A blood pressure sensor detects a decrease in blood pressure due to lower ECF. At least one SNS sensor detects an increase in at least one stress level (e.g., cardio stress, pulmonary blood oxygen stress, physical stress, gastro stress, thermoregulation stress, glucose stress, arterial stress, acid stress). A stabilized antibodies sensor detects a target antigen. In one example, the device indicates a color change to blue. A skin temperature sensor detects a decrease in skin temperature over several days as the body increases vasoconstriction and decreases sweat production in an attempt to maintain homeostasis. A sodium sensor detects an increase in sodium loss. A potassium sensor detects an increase in potassium loss. An accelerometer detects no significant diagnostic information early in the disease state. However, lethargy and decreases movement are likely to present if the patient is not treated. Clinical observations may include lethargy, loose stools, poor PO intake, and/or blood in the stools. Social media analytics are patient dependent. 
       FIG. 11F  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to a fight. In one example, the device includes a heart rate sensor, a blood oxygen sensor, a blood pressure sensor, at least one SNS sensor, a stabilized antibodies sensor, a skin temperature sensor, a sodium sensor, a potassium sensor, a glucose sensor, a pH sensor, and/or an accelerometer. A heart rate sensor detects an increase in heart rate due to fight or flight syndrome. A blood oxygen sensor detects a normal blood oxygen level or a slight increase in blood oxygen level. A blood pressure sensor detects an increase in blood pressure due to fight or flight syndrome. An SNS sensor detects an increase in gastro stress. A skin temperature sensor likely detects an increase in skin temperature due to an increase in sweating due to an increase in metabolic rate. A sodium sensor detects a normal sodium level. A potassium sensor detects a normal potassium level. A glucose sensor detects a glucose level within normal limits or a slightly increased glucose level due to fight or flight (catabolism and glycogenolysis), but the effect will be delayed. A pH sensor detects a normal pH. An accelerometer detects significant vector changes during the fight. Clinical observations may include signs of combat, such as hematomas in likely areas (e.g., arms, face, eyes, mouth) and/or broken ribs. Social media analytics are patient dependent. 
       FIG. 11G  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to measles. In one example, the device includes a heart rate sensor, a blood oxygen sensor, a blood pressure sensor, at least one SNS sensor, a stabilized antibodies sensor, a skin temperature sensor, a sodium sensor, a potassium sensor, a glucose sensor, a pH sensor, and/or an accelerometer. A heart rate sensor may detect an increase in baseline heart rate. In one example, the heart rate is increased if the patient is dehydrated from diarrhea and/or emesis. A blood oxygen sensor detects a normal blood oxygen level. A blood pressure sensor may detect a lower blood pressure in patients who are dehydrated due to diarrhea and/or emesis. A SNS sensor detects an increase in gastro stress. A stabilized antibodies sensor detects a target antigen. In one example, the device indicates a color change to blue. A skin temperature sensor detects an increase in skin temperature. For example, an initial sign of measles is often a high fever (e.g., above 104° F.) that typically lasts 4-7 days. A sodium sensor may detect an increase in sodium loss in patients who are dehydrated due to diarrhea and/or emesis. A potassium sensor may detect an increase in potassium loss in patients who are dehydrated due to diarrhea and/or emesis. A glucose sensor detects no noticeable changes in glucose level. A pH sensor may detect an alkalotic level in patients who are dehydrated due to diarrhea and/or emesis. An accelerometer detects no significant diagnostic information. Clinical observations may include malaise and/or anorexia associated with decreased activity. The prodromal phase lasts 7-14 days before fever begins. Social media analytics may include complaints related to a typical rash seen with viral diseases. However, measles is mostly a viral illness that affects children. 
       FIG. 11H  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to acute respiratory infections (flu). In one example, the device includes a heart rate sensor, a blood oxygen sensor, a blood pressure sensor, at least one SNS sensor, a stabilized antibodies sensor, a skin temperature sensor, a sodium sensor, a potassium sensor, a glucose sensor, a pH sensor, and/or an accelerometer. A heart rate sensor detects a normal heart rate or an increased heart rate due to an inflammatory response to the disease and/or hypoxia due to an infected lung. A blood oxygen sensor detects a normal blood oxygen level or a decreased blood oxygen level depending on the severity of the disease. A blood pressure sensor will likely detect a normal blood pressure unless the infection is causing a systemic inflammatory response and, thus, decreases blood pressure. A SNS sensor detects an increase in pulmonary stress. A stabilized antibodies sensor detects a target antigen. In one example, the device indicates a color change to blue. A skin temperature sensor detects an increase in skin temperature, a normal skin temperature, or a decrease in skin temperature depending on a degree of infection and a stage of infection. A sodium sensor detects no noticeable change in sodium level. A potassium sensor detects no noticeable change in potassium level. A glucose sensor detects a normal glucose level or an increased glucose level depending on the degree of infection and the stage of infection. A pH sensor detects a normal pH level or a decreased pH level depending on a degree of infection and a stage of infection. An accelerometer detects no significant diagnostic information. Clinical observations may include a normal appearance (early stages) or a very sick appearance with signs such as increased sweating, an increased respiratory rate, shortness of breath with minimal exertion, febrile seizures, and/or a productive cough that may or may not be associated with blood. Social media analytics are patient dependent. 
       FIG. 11I  shows a table of sensors that can be incorporated into the device and their associated biosignatures related to malnutrition. In one example, the device includes a heart rate sensor, a blood oxygen sensor, a blood pressure sensor, at least one SNS sensor, a stabilized antibodies sensor, a skin temperature sensor, a sodium sensor, a potassium sensor, a glucose sensor, a pH sensor, and/or an accelerometer. A heart rate sensor detects an increased heart rate during the initial phase of malnutrition and a decreased heart rate as energy stores begin to deplete. In advanced states of protein loss, a patient may have poor breathing and/or ventilatory function as detected by a blood oxygen sensor due to loss of intercostal and diaphragmatic muscle mass. This will lead to hypoxia and hypercarbia. A few studies have shown that malnourished children tend to have an increased blood pressure compared to control groups. Alternatively, in extreme conditions, poor heart function due to poor vitamin intake (e.g., Vitamin B1, also known as thiamine, which is a co-enzyme needed for proper cardiac muscle and nerve function) due to decreased stroke volume and bradycardia will cause a low blood pressure. Additionally, poor albumin and/or protein intake will lower effective circulating volume, also contributing to a lower blood pressure. A SNS sensor detects an increase in gastro stress. A skin temperature sensor detects a decrease in skin temperature over time as immune function and metabolism are negatively affected due to decreased protein and/or vitamin intake. The ability to maintain a normal body temperature will worsen. A sodium sensor generally detects a lower serum sodium concentration due to an overabundance of free water compared to sodium level, even though the patient has a sodium overload. The serum sodium concentration will also decrease to diarrhea. A potassium sensor detects a lower total body potassium due to decreased intake and poor muscle mass. Most serum levels are subclinical; however, in overt malnourished cases or concomitant diarrhea the serum level will be low. The mean fasting blood glucose level as detected by a glucose sensor is generally lower in malnourished children is lower compared to controls. The pH as measured by a pH sensor depends on the ability of hate kidneys to maintain a bicarbonate buffer. However, as cardiac output decreases, renal function will worsen and retention of free water will increase. This will dilute plasma electrolytes, which may lead to a decreased pH level. Hypercarbia from poor ventilatory function will increase blood serum activity. An accelerometer detects no significant diagnostic information. Clinical observations may include a gaunt appearance, a loss of muscle mass, and jaundice. Loss of energy or activity are common symptoms. Decreased gastrointestinal use will lead to gut wasting and bacterial translocation, thus leading to sepsis. As a note, the prevalence of malnutrition in hospitals around the world is up to 50%. Social media analytics are patient dependent. 
       FIG. 12  illustrates a core layout of an embodiment of the device including a flexible, replaceable sensor flap. The device has an electronic core including at least one multiplexer, at least one analog-to-digital converter, and at least one microprocessor. A flexible, replaceable sensor flap is connected to the electronic core. The flexible, replaceable sensor flap includes at least one sensor. In one embodiment, the at least one sensor is a sweat sensor, a sympathetic nervous system sensor (stress sensor), a stabilized antibodies sensor, and/or a pH sensor. In one embodiment, the at least one sensor includes at least one ion-selective electrode (ISE). In one embodiment, the ISE includes an ionophore polymer coating. Additionally, a flexible, replaceable communications flap is connected to the electronic core. The flexible, replaceable communications flap includes at least one transceiver antenna that is operable to provide wireless network communication with at least one remote transceiver device. In one embodiment, the transceiver antenna is a coil. In an alternative embodiment, the transceiver antenna is a radio frequency (RF) antenna. In one embodiment, the flexible, replaceable sensor flap and/or the flexible replaceable communications flap are connected to the electronic core via a zero insertion force (ZIF) connector. Advantageously, the flexible, replaceable sensor flap and the flexible, replaceable communications flap allow for upgrading sensors and communications without replacing the electronic core. This allows the device to be modified for particular conditions and/or mission needs. For example, a device can be upgraded to include a stabilized antibodies sensor following a disease outbreak without replacing the entire device. 
     In one embodiment, the device is an ear sensor. In one example, the ear sensor includes a heart rate sensor, a blood oxygen sensor, a blood pressure sensor, at least one temperature sensor (e.g., skin temperature, core temperature, ambient temperature), and/or a motion sensor (e.g., accelerometer). In another embodiment, the device is a patch. In one example, the patch includes a sweat sensor to monitor at least one analyte (e.g., sodium, potassium, cortisol), at least one temperature sensor (e.g., skin temperature, core temperature, ambient temperature), and/or a motion sensor (e.g., accelerometer). 
       FIGS. 13A-13G  illustrate electronic components of one embodiment of the device.  FIG. 13A  illustrates one embodiment of a microcontroller. The microcontroller preferably includes at least one memory. In one embodiment, the at least one memory is RAM, ROM, EPROM, EEPROM, and/or FLASH memory. In the embodiment shown in  FIG. 13A , the microcontroller is part number ATtiny1634 by Atmel. Information for part number ATtiny1634 is in the datasheet for ATtiny1634, DOC ID Atmel-8303H-AVR-ATtiny1634-Datasheet by Atmel dated February 2014, which is incorporated herein by reference in its entirety. Alternative microcontrollers are compatible with the present invention. 
       FIG. 13B  illustrates one embodiment of an accelerometer. The accelerometer is preferably a 3-axis accelerometer. The accelerometer is preferably operable to function as a pedometer. In one embodiment, the accelerometer is a MEMS digital output motion sensor. In the embodiment shown in  FIG. 13B , the accelerometer is a MEMS digital output motion sensor, part number LIS331HH by STMicroelectronics. Information for part number LIS331HH is in the datasheet for LIS331HH, DOC ID 163366, REV. 1 by STMicroelectronics dated October 2009, which is incorporated herein by reference in its entirety. Alternative accelerometers are compatible with the present invention. 
       FIG. 13C  illustrates one embodiment of an integrated blood oxygen sensor and heart rate monitor. The blood oxygen sensor is preferably a pulse oximeter. In the embodiment shown in  FIG. 13C , the integrated blood oxygen sensor and heart rate monitor is part number MAX30102EFD+ by Maxim Integrated. Information for part number MAX30102EFD+ is in the datasheet for MAX30102, DOC ID 19-7740, REV. 0 by Maxim Integrated dated September 2015, which is incorporated herein by reference in its entirety. Alternative blood oxygen sensors and/or heart rate monitors are compatible with the present invention. 
       FIG. 13D  illustrates one embodiment of a connector that connects debuggers, programmers, and test equipment to a printed circuit board (PCB). In the embodiment shown in  FIG. 13D , the connector is a Tag-Connect programming pad, part number TC2030-IDC-NL. Alternative connectors are compatible with the present invention. 
       FIG. 13E  illustrates one embodiment of an NFC antenna connector. In the embodiment shown in  FIG. 13E , the NFC antenna connector is formed of part number FH12-6S-1SH(55) by Hirose Electric Co. Alternative antenna connectors are compatible with the present invention. 
       FIG. 13F  illustrates one embodiment of pull up resistors connected to the microcontroller in  FIG. 13A . 
       FIG. 13G  illustrates one embodiment of a pull down resistor connected to the microcontroller in  FIG. 13A . 
     A diagram of the system communications is shown in  FIG. 14 . The biosensor array sends signals to a multiplexer (MUX), which pulls in signals from all of the sensors and all of the modalities. The signals are conditioned through a series of capacitors and resistors before the signals are converted using an ADC with a programmable amplifier. The amplifier gain is customized to each sensor signal type. The ADC signals are passed to the microprocessor for processing, converting, and storage. The microprocessor manages read times, gains, processing, and store instructions. Data in storage is extracted via a communications event (e.g., NFC scan, BLUETOOTH read, burst) and transmitted to at least one remote transceiver device (e.g., mobile application on a smartphone or tablet, security kiosk). The remote transceiver device is operable to send the data to a cloud and/or at least one remote computer server for storage and/or processing. Types of output data include but are not limited to concentrations (e.g., molarity, osmolarity, and osmolality), heart rate, oxygen saturation, blood pressure, positive or negative viral and/or bacterial tests, temperatures, glucose levels, pH, accelerometer measurements, SNS measurements, and descriptive statistics (e.g., averages, ratios, trends, and patterns). 
     The at least one remote transceiver device and the sensor apparatus are operable for two-way cross-communication in real time or near real time. The at least one remote transceiver device is operable to communicate with the sensor apparatus to provide, by way of example and not limitation, commands, electrode calibration, software updates, new or updated algorithms, and/or new or updated modifying variables for algorithms. The sensor apparatus is operable to communicate with the at least one remote transceiver device to provide, by way of example and not limitation, output data, processor health properties (e.g., microcontroller health properties), error codes, electrode maintenance, or malfunction. In a preferred embodiment, the remote transceiver device is operable to allow at least one user to view data from at least one sensor apparatus, including sensor history, output data, and biosignature data for an individual. Additionally, or alternatively, the remote transceiver device is operable to allow at least one user to view data from a plurality of sensor apparatuses, including output data, biosignature data, and overall population trends. 
     The at least one remote transceiver device and the cloud and/or the at least one remote computer server are operable for two-way cross-communication in real time or near real time. In one embodiment, the cloud and/or the at least one remote computer server is operable to transmit the commands, the electrode calibration, the software updates, the new or updated algorithms, the new or updated modifying variables for algorithms to the at least one remote transceiver device. In another embodiment, the cloud and/or the at least one remote computer server is operable to provide software updates for the at least one remote transceiver device (e.g., updates to the mobile application). The data from the sensor apparatus is augmented by additional information and/or external factors. In one embodiment, the additional information and/or the external factors are stored in the cloud and/or on the at least one remote computer server. For example, the additional information and/or external factors include results of laboratory tests, clinical observations, offline analytics, eyewitness data, web data, and third party web services (e.g., weather, World Health Organization (WHO) and International Organization for Migration (IOM) alerts). Additionally, social media use can be monitored to supplement the data from the sensor apparatus. In a preferred embodiment, the additional information and/or the external factors are processed with the data from the sensor apparatus in the cloud and/or on the at least one remote computer server. 
       FIG. 15  illustrates one embodiment of the invention as a refugee care system. The system is also operable to be used as an air crew safety system, an elderly care system, a crowd care system, an athletic care system, a border or customs risk mitigation system, a disaster triage system, and a military field medical system. As shown in  FIG. 15 , a device  1510  is placed on a refugee&#39;s arm by a humanitarian aid worker. The device  1510  is initialized and begins to collect data. In one embodiment, the device  1510  is initialized by at least one remote transceiver device  230  (e.g., smartphone, tablet). In a preferred embodiment, the data is anonymized. An advanced profile view shows key biomarker trends and discrepancies among the population prior to entry in the refugee camp. The device  1510  is scanned at a bio-scan security kiosk  1520 , which uploads the data in the memory of the device  1510  to a humanitarian health record platform  1530  and resets the memory. The humanitarian health record platform  1530  interfaces with third party web services, such as weather, World Health Organization (WHO) alerts, and/or International Organization for Migration (IOM) alerts. The humanitarian health record platform  1530  allows humanitarian organizations (e.g., Red Cross) to observe trends of the population and manage localized disease outbreaks. Additionally, medical doctors are able to provide anonymized individual refugee assistance. In another embodiment, refugees and/or locals are employed to scan the device  1510 . In a preferred embodiment, the device  1510  measures a change in heart rate, a change in oxygen saturation, a change in skin temperature, and a change in glucose in 10 second reads every 10 minutes. 
     A diagram of the system architecture is shown in  FIG. 16 . The sensor apparatus is in wireless communication with at least one remote transceiver device (e.g., a mobile application, security kiosk). In a preferred embodiment, the mobile application is on a smartphone. Alternatively, the mobile application is on a tablet, a laptop computer, or a desktop computer. In one embodiment, the mobile application is in network communication with a user web service, as shown in  FIG. 17 , to access the cloud database and a library. In one embodiment, the library includes functions, such as file storage, security, extensions, utilities, scheduling, messaging, persistence, cache, and/or logging. 
     From the cloud computing system, data including X-Mod results from multiple users may be stored, as diagrammed in  FIG. 18 . Data from a plurality of sensor apparatuses  10  is transmitted to a plurality of remote transceiver devices  40 . Data is then transmitted from the plurality of remote transceiver devices  40  to the network and cloud computing system. Data from the network and cloud computing system can be used by researchers, coaches, and public health officials in real time or over time drawing on historical data for research analytics. In a preferred embodiment, the data is from sensor apparatuses with the same configuration, providing greater reliability to the pool of data. The ability to collect biosignature data from a large population of subjects provides a real-time public health research system and method. 
     Additionally, the ability to collect biosignature data from a large population of subjects provides physicians with a method of monitoring a specific population and/or performing triage. For example, the sensor apparatus can be placed on victims of a disaster, allowing physicians to monitor victims and attend to the most critically injured victims first. The sensor apparatus can also be used to monitor prisoners for health issues and/or fighting. Alternatively, the sensor apparatus can be used to monitor alcoholics or drug addicts for relapse. 
       FIG. 19  is a schematic diagram of an embodiment of the invention illustrating a computer system, generally described as  800 , having a network  810 , a plurality of computing devices  820 ,  830 ,  840 , a server  850 , and a database  870 . 
     The server  850  is constructed, configured, and coupled to enable communication over a network  810  with a plurality of computing devices  820 ,  830 ,  840 . The server  850  includes a processing unit  851  with an operating system  852 . The operating system  852  enables the server  850  to communicate through network  810  with the remote, distributed user devices. Database  870  may house an operating system  872 , memory  874 , and programs  876 . 
     In one embodiment of the invention, the system  800  includes a cloud-based network  810  for distributed communication via a wireless communication antenna  812  and processing by at least one mobile communication computing device  830 . Alternatively, wireless and wired communication and connectivity between devices and components described herein include wireless network communication such as WI-FI, WORLDWIDE INTEROPERABILITY FOR MICROWAVE ACCESS (WIMAX), Radio Frequency (RF) communication including RF identification (RFID), NEAR FIELD COMMUNICATION (NFC), BLUETOOTH including BLUETOOTH LOW ENERGY (BLE), ZIGBEE, Infrared (IR) communication, cellular communication, satellite communication, Universal Serial Bus (USB), Ethernet communications, communication via fiber-optic cables, coaxial cables, twisted pair cables, and/or any other type of wireless or wired communication. In another embodiment of the invention, the system  800  is a virtualized computing system capable of executing any or all aspects of software and/or application components presented herein on the computing devices  820 ,  830 ,  840 . In certain aspects, the computer system  800  may be implemented using hardware or a combination of software and hardware, either in a dedicated computing device, or integrated into another entity, or distributed across multiple entities or computing devices. 
     By way of example, and not limitation, the computing devices  820 ,  830 ,  840  are intended to represent various forms of digital computers  820 ,  840 ,  850  and mobile devices  830 , such as a server, blade server, mainframe, mobile phone, personal digital assistant (PDA), smartphone, desktop computer, netbook computer, tablet computer, workstation, laptop, and other similar computing devices. The components shown here, their connections and relationships, and their functions, are meant to be exemplary only, and are not meant to limit implementations of the invention described and/or claimed in this document 
     In one embodiment, the computing device  820  includes components such as a processor  860 , a system memory  862  having a random access memory (RAM)  864  and a read-only memory (ROM)  866 , and a system bus  868  that couples the memory  862  to the processor  860 . In another embodiment, the computing device  830  may additionally include components such as a storage device  890  for storing the operating system  892  and one or more application programs  894 , a network interface unit  896 , and/or an input/output controller  898 . Each of the components may be coupled to each other through at least one bus  868 . The input/output controller  898  may receive and process input from, or provide output to, a number of other devices  899 , including, but not limited to, alphanumeric input devices, mice, electronic styluses, display units, touch screens, signal generation devices (e.g., speakers), or printers. 
     By way of example, and not limitation, the processor  860  may be a general-purpose microprocessor (e.g., a central processing unit (CPU)), a graphics processing unit (GPU), a microcontroller, a Digital Signal Processor (DSP), an Application Specific Integrated Circuit (ASIC), a Field Programmable Gate Array (FPGA), a Programmable Logic Device (PLD), a controller, a state machine, gated or transistor logic, discrete hardware components, or any other suitable entity or combinations thereof that can perform calculations, process instructions for execution, and/or other manipulations of information. 
     In another implementation, shown as  840  in  FIG. 19 , multiple processors  860  and/or multiple buses  868  may be used, as appropriate, along with multiple memories  862  of multiple types (e.g., a combination of a DSP and a microprocessor, a plurality of microprocessors, one or more microprocessors in conjunction with a DSP core). 
     Also, multiple computing devices may be connected, with each device providing portions of the necessary operations (e.g., a server bank, a group of blade servers, or a multi-processor system). Alternatively, some steps or methods may be performed by circuitry that is specific to a given function. 
     According to various embodiments, the computer system  800  may operate in a networked environment using logical connections to local and/or remote computing devices  820 ,  830 ,  840 ,  850  through a network  810 . A computing device  830  may connect to a network  810  through a network interface unit  896  connected to a bus  868 . Computing devices may communicate communication media through wired networks, direct-wired connections or wirelessly, such as acoustic, RF, or infrared, through an antenna  897  in communication with the network antenna  812  and the network interface unit  896 , which may include digital signal processing circuitry when necessary. The network interface unit  896  may provide for communications under various modes or protocols. 
     In one or more exemplary aspects, the instructions may be implemented in hardware, software, firmware, or any combinations thereof. A computer readable medium may provide volatile or non-volatile storage for one or more sets of instructions, such as operating systems, data structures, program modules, applications, or other data embodying any one or more of the methodologies or functions described herein. The computer readable medium may include the memory  862 , the processor  860 , and/or the storage media  890  and may be a single medium or multiple media (e.g., a centralized or distributed computer system) that store the one or more sets of instructions  900 . Non-transitory computer readable media includes all computer readable media, with the sole exception being a transitory, propagating signal per se. The instructions  900  may further be transmitted or received over the network  810  via the network interface unit  896  as communication media, which may include a modulated data signal such as a carrier wave or other transport mechanism and includes any delivery media. The term “modulated data signal” means a signal that has one or more of its characteristics changed or set in a manner as to encode information in the signal. 
     Storage devices  890  and memory  862  include, but are not limited to, volatile and non-volatile media such as cache, RAM, ROM, EPROM, EEPROM, FLASH memory, or other solid state memory technology; discs (e.g., digital versatile discs (DVD), HD-DVD, BLU-RAY, compact disc (CD), or CD-ROM) or other optical storage; magnetic cassettes, magnetic tape, magnetic disk storage, floppy disks, or other magnetic storage devices; or any other medium that can be used to store the computer readable instructions and which can be accessed by the computer system  800 . 
     It is also contemplated that the computer system  800  may not include all of the components shown in  FIG. 19 , may include other components that are not explicitly shown in  FIG. 19 , or may utilize an architecture completely different than that shown in  FIG. 19 . The various illustrative logical blocks, modules, elements, circuits, and algorithms described in connection with the embodiments disclosed herein may be implemented as electronic hardware, computer software, or combinations of both. To clearly illustrate this interchangeability of hardware and software, various illustrative components, blocks, modules, circuits, and steps have been described above generally in terms of their functionality. Whether such functionality is implemented as hardware or software depends upon the particular application and design constraints imposed on the overall system. Skilled artisans may implement the described functionality in varying ways for each particular application (e.g., arranged in a different order or partitioned in a different way), but such implementation decisions should not be interpreted as causing a departure from the scope of the present invention. 
     The above-mentioned examples are provided to serve the purpose of clarifying the aspects of the invention, and it will be apparent to one skilled in the art that they do not serve to limit the scope of the invention. By way of example, the glucose sensor can measure glucose levels in blood, interstitial fluid, or sweat using a disposable patch. Sweat sensors can analyze various biomarkers, including glucose, calcium, ammonium, amino acids, hormones, steroids, proteins, and interleukins. The above-mentioned examples are just some of the many configurations that the mentioned components can take on. All modifications and improvements have been deleted herein for the sake of conciseness and readability but are properly within the scope of the present invention.