Patent Publication Number: US-4921527-A

Title: Herbicidal sulfonamides

Description:
RELATED APPLICATION 
     This application is a continuation-in-part of application U.S. Ser. No. 080,471 filed July 31, 1987, now abandoned. 
    
    
     BACKGROUND OF THE INVENTION 
     This invention relates to novel sulfonylurea compounds, agriculturally suitable compositions thereof and a method of using them to control the growth of undesired vegetation. 
     New compounds effective for controlling the growth of undesired vegetation are in constant demand. In the most common situation, such compounds are sought to selectively control the growth of weeds in useful crops such as cotton, rice, corn, wheat and soybeans, to name a few. Unchecked weed growth in such crops can cause significant losses, reducing profit to the farmer and increasing costs to the consumer. In other situations, herbicides are desired which will control all plant growth. Examples of areas in which complete control of all vegetation is desired are areas around railroad tracks, and industrial storage areas. There are many products commercially available for these purposes, but the search continues for products which are more effective, less costly and environmentally safe. 
     The &#34;sulfonylurea&#34; herbicides are an extremely potent class of herbicides discovered within the last few years. A multitude of structural variations exist within this class of herbicides, but they generally consist of a sulfonylurea bridge, --SO 2  NHCONH--, 
     U.S. No. 4,369,320 and U.S. No. 4,453,970 disclose herbicidal quinolinylsulfonylureas. 
     U.S. No. 4,391,627 discloses herbicidal benzothiophenesulfonylureas. 
     EP-A-70,698 published 1/26/83 discloses herbicidal indolesulfonylureas. 
     EP-A-146,263, published 6/26/85 discloses herbicidal sulfonylureas of the formula ##STR1## wherein J is ##STR2## E is a bridge of 3 or 4 atoms, which may be substituted or unsubstituted, containing 0 to 2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen and also containing 1-4 atoms of carbon, said bridge together with two carbon attachment sites forming a partially saturated 5- to 6-membered carbocyclic or heterocyclic ring; or E is a bridge of 3 or 4 atoms which may be substituted or unsubstituted containing at least 1 heteroatom selected from 0-1 oxygen or sulfur or 0-2 nitrogen and 1-3 atoms of carbon, said bridge together with two carbon attachment sites forming an unsaturated 5- to 6-membered heterocyclic ring, with the proviso that when E contains two atoms of oxygen or sulfur, then they must be separated by at least one atom of carbon and that oxygen and sulfur are only linked to each other if the sulfur is in the form of SO or SO 2  ; in the bridging group E, nitrogen may take the form of N or N--O, sulfur may take the form of S, SO or SO 2 , and one of the atoms of carbon may be a carbonyl, thiocarbonyl or the cyclic 5- and 6-membered ketals thereof; and 
     G is O, S, NH or NCH 3 . 
     U.S. No. 4,622,062 disclosed herbicidal sulfonylureas of the formula ##STR3## wherein L, in part, is ##STR4## Q 1  is O, S or SO 2 . 
     U.S. No. 4,643,759 discloses herbicidal compounds of the formula ##STR5## wherein Q is ##STR6## W is O, S or NR 3   
     U.S. No. 4,678,499 discloses herbicidal compounds of the formula ##STR7## wherein Q is ##STR8## G is CH 2 , CH 2  CH 2 , O, S, NH, NCH 3  or CH═CH; G 1  is CH 2 , CH 2  CH 2  or CH═CH; 
     J, in part, is CH 2 , C(O), S(O) m , O, NH or NCH 3  ; 
     n and n 1  are independently 0 or 1; and 
     E is a bridge of 3 or 4 atoms containing 0-2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, wherein 1 atom of sulfur may take the form of SO or SO 2 , said bridge also containing 1 to 4 atoms of carbon wherein 1 atom of carbon may take the form of C═O, said bridge together with two attachment sites forming a non-aromatic heterocyclic or carbocyclic ring optionally substituted by 1 to 3 substituent groups selected from the group L, or E is a bridge of 3 or 4 atoms containing 0-1 heteroatoms of oxygen or sulfur and 0-3 heteroatoms of nitrogen, said bridge also containing 0-4 atoms of carbon, said bridge together with two attachment sites forming an aromatic heterocyclic or carbocyclic ring optionally substituted by 1 to 3 substituents selected from the group L, with the proviso that when E contains two oxygen atoms or two sulfur atoms said atoms must be separated by at least one atom of carbon and that oxygen and sulfur are only linked to each other if the sulfur is in the form of SO or SO 2  ; 
     U.S. No. 4,671,817 discloses herbicidal compounds of the formula ##STR9## wherein L is ##STR10## 
     U.S. No. 4,723,987 discloses herbicidal compounds of the formula ##STR11## wherein J is ##STR12## E is a bridge of 3 or 4 atoms, which may be substituted or unsubstituted, containing 0-2 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, and also containing 1-4 atoms of carbon, said bridge together with two carbon attachment sites forming a partially saturated 5- or 6-membered carbocyclic or heterocyclic ring; or E is a bridge of 3 or 4 atoms, which may be substituted or unsubstituted, containing 0-1 heteroatoms selected from oxygen or sulfur, 0-2  heteroatoms of nitrogen and 1-4 atoms of carbon said bridge together with two carbon attachment sites forming a fully unsaturated 5- or 6-membered carbocyclic or heterocyclic ring, with the proviso that when E contains two atoms of oxygen or sulfur, they must be separated by at least one atom of carbon, and the oxygen and sulfur are only linked to each other if the sulfur is in the form of SO or SO 2  ; in the bridging group E, sulfur may take the form of S, SO or SO 2 , and one of the atoms of carbon may be a carbonyl, thiocarbonyl or the cyclic 5- and 6-membered ketals thereof. 
     South African Patent Application 84/8844 and its equivalent U.S. No. 4,605,433, discloses substituted 1,2,4-triazolo-[1,5-a]pyrimidine-sulfonamides of the following formula as herbicides and plant growth regulants. ##STR13## 
     U.S. No. 4,685,958, discloses substituted 2-amino-1,2,4-triazolo[1,5-A]-1,3,5-triazines of the following formula as herbicides. ##STR14## 
     EP-A-244,097, published on Nov. 4, 1987, discloses herbicidal pyrazolopyrimidine derivatives of the formula ##STR15## wherein X is --NR--SO 2  --, --SO 2  --O--, --SO 2  --NR-- or --S(O) n  CR&#39;R&#34;--. 
     EP-A-244,098, published on Nov. 4, 1987, discloses herbicidal thiazolotriazolesulfonamides of the formula ##STR16## 
     U.S. Ser. No. 07/039492 which was allowed discloses herbicidal benzotriazole sulfonylureas. 
     EP-A-244,166, published Nov. 4, 1987, discloses herbicidal compounds of the formula ##STR17## wherein L, in part, is a benzene, naphthalene, pyrazole, thiophene, pyridine, benzothiophene or an indole moiety; 
     A, in part is ##STR18## Z is CH, N, CCH 3 , CEt, CCl or CBr; Z 1  is C--U, N or N--O; 
     Z 2  and Z 3  are independently N or C--U; 
     Z 4  is NCH 3 , O, S or CH 2  ; and 
     U is H, F, Cl, Br, C 1  -C 2  alkyl optionally substituted by F, Cl, Br or OCH 3 , CN, NO 2 , NMe 2 , OR 22 , or SR 22 , or CO 2  CH 3 . 
     EP-A-238,070, published Sept. 23, 1987,  discloses compounds of the formula ##STR19## wherein Q is a condensed heterocyclic group having N atoms in the bridgehead which may be substituted; 
     W is O or S; 
     R 1  and R 2  are independently alkyl, alkoxy or halogen; and 
     Z is CH or N. 
     SUMMARY OF THE INVENTION 
     This invention relates to novel compounds of Formula I, their agriculturally suitable compositions and their method-of-use as preemergent and/or postemergent herbicides or plant growth regulants ##STR20## wherein L is ##STR21## R 1  is H, halogen, C 1  -C 3  alkyl, C 1  -C 3  haloalkyl, OR 6 , SR 6 , S(O)R 6 , S(O) 2  R 6 , CO 2  R 7 , C(O)NR 8  R 9 , S(O) 2  NR 10  R 11 , C 2  -C 3  alkenyl, C 2  -C 3  haloalkenyl, C 2  -C 3  alkynyl, NO 2 , CN, C(O)R 12 , C(R 13 )═NOR 14  or C 1  -C 2  alkyl substituted by C 1  -C 2  alkoxy, C 1  -C 2  alkylthio or CN; 
     R 2  is H, C 1  -C 3  alkyl, C 1  -C 3  alkoxy, C 1  -C 2  haloalkoxy or C 1  -C 2  alkyl substituted with OCH 3 , SCH 3  or CN; 
     R 3  is H, CH 3  or OCH 3  ; 
     R 4  is H or CH 3  ; 
     R 5  is H, halogen, C 1  -C 3  alkyl, C 1  -C 3  haloalkyl, OR 6 , SR 6 , S(O) 2  R 6 , CO 2  R 7 , C(O)NR 8  R 9 , S(O) 2  NR 10  R 11 , C 2  -C 3  alkenyl, C 2  -C 3  haloalkenyl, C 2  -C 3  alkynyl, NO 2 , CN, C(O)R 12 , or C 1  -C 2  alkyl substituted by C 1  -C 2  alkoxy, C 1  -C 2  alkylthio or CN; 
     R 6  is C 1  -C 3  alkyl, C 1  -C 3  haloalkyl, C 3  alkenyl, C 2  -C 3  haloalkenyl, propargyl, cyclopropyl, cyclopropylmethyl or --CH 2  CH 2  -- substituted by OH, C 1  -C 2  alkoxy, SH, C 1  -C 2  thioalkyl or CN; 
     R 7  is C 1  -C 4  alkyl, C 2  -C 3  haloalkyl, allyl, propargyl, cyclopropyl, cyclopropylmethyl, or --CH 2  CH 2  -- substituted by OH, OCH 3 , SCH 3  or CN; 
     R 8  is H or C 1  -C 2  alkyl; 
     R 9  is C 1  -C 3  alkyl, C 1  -C 3  alkoxy, allyl, propargyl, cyclopropyl, CH 2  CN, CH 2  CH 2  CN Or CH 2  CH 2  OCH 3  ; 
     R 10  is H or C 1  -C 3  alkyl; 
     R 11  is C 1  -C 3  alkyl, C 1  -C 3  alkoxy, allyl, propargyl, cyclopropyl, cyclopropylmethyl, CH 2  CN, CH 2  CN, CH 2  CH 2  CN or CH 2  CH 2  OCH 3  ; 
     R 10  and R 11  can be taken together to form a ring consisting of (--CH 2  --) 4 , (--CH 2  --) 5  or (--CH 2  CH 2  --) 2  O; 
     R 12  is H, C 1  -C 3  alkyl or cyclopropyl; 
     R 13  is H, C 1  -C 3  alkyl, cyclopropyl, Cl, CN, OCH 3 , SCH 3  or N(CH 3 ) 2  ; 
     R 14  is H or C 1  -C 3  alkyl; 
     Z is N or CH; 
     Z 1  is N, CH or CCH 3  ; 
     Z 2  is O, S or NCH 3  ; 
     Z 3  is O, S or N--R 15  ; 
     R 15  is H, C 1  -C 2  alkyl, C 1  -C 2  haloalkyl, CH 2  CH 2  OCH 3 , CH 2  CH 2  SCH 3 , CH 2  CN or CO 2  CH 3  ; 
     W is O or S; 
     R is H or CH 3  ; 
     A is ##STR22## X is H, C 1  -C 4  alkyl, C 1  -C 4  alkoxy, C 1  -C 4  haloalkoxy, C 1  -C 4  haloalkyl, C 1  -C 4  haloalkylthio, C 1  -C 4  alkylthio, halogen, C 2  -C 5  alkoxyalkyl, C 2  -C 5  alkoxyalkoxy, amino, C 1  -C 3  alkylamino or di(C 1  -C 3  alkyl)amino; 
     Y is H, C 1  -C 4  alkyl, C 1  -C 4  alkoxy, C 1  -C 4  haloalkoxy, C 1  -C 4  haloalkylthio, C 1  -C 4  alkylthio, C 2  -C 5  alkoxyalkyl, C 2  -C 5  alkoxyalkoxy, amino, C 1  -C 3  alkylamino, di(C 1  -C 3  alkyl)amino, C 3  -C 4  alkenyloxy, C 3  -C 4  alkynyloxy, C 2  -C 5  alkyl thioalkyl, C 2  -C 5  alkylsulfinylalkyl, C 2  -C 5  alkylsulfonylalkyl, C 1  -C 4  haloalkyl, C 2  -C 4  alkynyl, C 3  -C 5  cycloalkyl, azido, cyano, ##STR23##  or N(OCH 3 )CH 3  ; m is 2 or 3; 
     Q 1  and Q 2  are independently O or S; 
     R a  is H or C 1  -C 3  alkyl; 
     R b  and R c  are independently C 1  -C 3  alkyl; 
     Z 4  is CH, N, CCH 3 , CC 2  H 5 , CCl or CBr; 
     Z 5  is CH or N; 
     Y 1  is O or CH 2  ; 
     X 1  is CH 3 , OCH 3 , OC 2  H 5  or OCF 2  H; 
     X 2  is CH 3 , C 2  H 5  or CH 2  CF 3  ; 
     Y 2  is OCH 3 , OC 2  H 5 , SCH 3 , SC 2  H 5 , CH 3  or CH 2  CH 3  ; 
     X 3  is CH 3  or OCH 3  ; 
     Y 3  is H or CH 3  ; 
     X 4  is CH 3 , OCH 3 , OC 2  H 5 , CH 2  OCH 3  or Cl; 
     Y 4  is CH 3 , OCH 3 , OC 2  H 5  or Cl; 
     and their agriculturally suitable salts; provided that 
     (l) when X is halogen, then Z 4  is CH and Y is OCH 3 , OC 2  H 5 , NH 2 , NHCH 3 , N(CH 3 ) 2 , OCF 2  H, OCF 2  Br or N(OCH 3 )CH 3  ; 
     (2) when X or Y is C 1  haloalkoxy, then Z 4  is CH; 
     (3) when W is S, then R is H, A is A-1, Z 4  is CH or N, and Y is CH 3 , OCH 3 , OC 2  H 5 , CH 2  OCH 3 , C 2  H 5 , CF 3 , SCH 3 , OCH 2  CH═CH 2 , OCH 2  C.tbd.CH, OCH 2  CH 2  OCH 3 , CH(OCH 3 ) 2  or ##STR24## (4) when the total number of carbon atoms of X and Y is greater than four, then the greatest combined number of carbons of any two substituents on an L, selected from R 1 , R 2 , R 3 , R 4 , R 5   and R 15  is less than or equal to six; 
     (5) X 4  and Y 4  are not simultaneously Cl; 
     (6) the total number of carbon atoms of R 10  and R 11  is less than or equal to five. 
     In the above definitions, the term &#34;alkyl&#34;, used either alone or in compound words such as &#34;alkylthio&#34; or &#34;haloalkyl&#34;, denotes straight chain or branched alkyl, e.g. methyl, ethyl, n-propyl, isopropyl or the different butyl isomers. 
     Alkoxy denotes methoxy, ethoxy, n-propyloxy, isopropyloxy and the different butyloxy isomers. 
     Alkenyl denotes straight chain or branched alkenes, e.g. 1-propenyl, 2-propenyl, 3-propenyl and the different butenyl isomers. 
     Alkynyl denotes straight chain or branched alkynes, e.g. ethynyl, 1-propynyl, 2-propynyl and the different butynyl isomers. 
     Alkylsulfonyl denotes methylsulfonyl, ethylsulfonyl and the different propylsulfonyl isomers. 
     Alkylthio, alkylsulfinyl, alkylamino, etc. are defined analogously to the above examples. 
     Cycloalkyl denotes cyclopropyl, cyclobutyl and cyclopentyl. 
     The term &#34;halogen,&#34; either alone or in compound words such as &#34;haloalkyl,&#34; denotes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as &#34;haloalkyl&#34; said alkyl may be partially halogenated or fully substituted with halogen atoms and said halogen atoms may be the same or different. Examples of haloalkyl include CH 2  CH 2  F, CF 2  CF 3  and CH 2  CHFCl. 
     The total number of carbon atoms in a substituent group is indicated by the C i  -C j  prefix where i and j are numbers from 1 to 5. For example, C 1  -C 3  alkylsulfonyl would designate methylsulfonyl through propylsulfonyl, C 2  alkoxyalkoxy would designate OCH 2  OCH 3 , C 2  cyanoalkyl would designate CH 2  CN and C 3  cyanoalkyl would designate CH 2  CH 2  CN and CH(CN)CH 3 . 
     Compounds of the invention preferred for reasons of increased ease of synthesis and/or greater herbicidal efficacy are: 
     1. Compounds of Formula I where L is L-1, , L-3, L-4a, L-4b, L-5, L-6, L-7, L-10, L-11, L-14, L-16, L-19 or L-20. 
     2. Compounds of Preferred 1 where W is O and Z 4  is CH or N. 
     3. Compounds of Preferred 2 where 
     X is C 1  -C 2  alkyl, C 1  -C 2  alkoxy, Cl, F, Br, I, OCF 2  H, CH 2  F, CF 3 , OCH 2  CH 2  F, OCH 2  CHF 2 , OCH 2  CF 3 , CH 2  Cl or CH 2  Br; 
     Y is H, C 1  -C 2  alkyl, C 1  -C 2  alkoxy, CH 2  OCH 3 , CH 2  OCH 2  CH 3 , NHCH 3 , N(OCH 3 )CH 3 , N(CH 3 ) 2 , CF 3 , SCH 3 , OCH 2  CH═CH 2 , OCH 2  C.tbd.CH, OCH 2  CH 2  OCH 3 , CH 2  SCH 3 , ##STR25##  OCF 2  H, OCF 2  Br, SCF 2  H, cyclopropyl, C.tbd.CH or C.tbd.CCH 3  ; 
     R a  is H or CH 3  ; and 
     R b  and R c  are independently CH 3  or CH 2  CH 3 . 
     4. Compounds of Preferred 3 where 
     R 1  is H, halogen, C 1  -C 2  alkyl, C 1  -C 2  haloalkyl, OR 6 , SR 6 , S(O)R 6 , S(O) 2  R 6 , CO 2  R 7 , C(O)NR 8  R 9 , S(O) 2  NR 10  R 11 , C 2  -C 3  alkenyl, C 2  -C 3  haloalkenyl, NO 2 , CN, C(O)R 12 , C(R 13 )═NOR 14  or C 1  -C 2  alkyl substituted by C 1  -C 2  alkoxy, C 1  -C 2  alkylthio or CN; 
     R 2  is H, CH 3  or OCH 3  ; 
     R 5  is H, halogen, C 1  -C 2  alkyl, 
     C 1  -C 2  haloalkyl, OR 6 , SR 6 , S(O)R 6 , S(O) 2  R 6 , CO 2  R 7 , C(O)NR 8  R 9 , S(O) 2  NR 10  R 11 , C 2  -C 3  alkenyl, C 2  -C 3  haloalkenyl, NO 2 , CN, C(O)R 12 , or C 1  -C 2  alkyl substituted by C 1  -C 2  alkoxy, C 1  -C 2  alkylthio or CN; 
     R 6  is C 1  -C 3  alkyl, C 1  -C 3  haloalkyl, C 3  alkenyl, C 2  -C 3  haloalkenyl, propargyl, cycloproyl or cyclopropylmethyl. 
     5. Compounds of Preferred 4 where 
     A is A-1; 
     X is CH 3 , OCH 3 , OCH 2  CH 3 , Cl or OCF 2  H; 
     Y is CH 3 , OCH 3 , C 2  H 5 , CH 2  OCH 3 , NHCH 3 , CH(OCH 3 ) 2  or cyclopropyl; and 
     R is H. 
     6. Compounds of Preferred 5 where L is L-1. 
     7. Compounds of Preferred 5 where L is L-3. 
     8. Compounds of Preferred 5 where L is L-4a. 
     9. Compounds of Preferred 5 where L is L-4b. 
     10. Compounds of Preferred 5 where L is L-5. 
     11. Compounds of Preferred 5 where L is L-6. 
     12. Compounds of Preferred 5 where L is L-7. 
     13. Compounds of Preferred 5 where L is L-10. 
     14. Compounds of Preferred 5 where L is L-11. 
     15. Compounds of Preferred 5 where L is L-14. 
     16. Compounds of Preferred 5 where L is L-19. 
     17. Compounds of Preferred 5 where L is L-20. 
     The compounds of this invention are active are active preemergent and postemergent herbicides and plant growth regulants. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     Synthesis 
     Compounds of Formula I can be prepared by one or more of the procedures shown in Equations 1, 4, and 5 wherein L, R, and A are as previously defined. The requisite intermediates for these reactions can be prepared by one or more of the methods described in this section. In some cases, substituents on the starting materials may be incompatible with the reaction conditions described. It will be readily apparent to one skilled in the art to use either standard protecting groups (e.g., ketal as a protecting group for ketone) or one of the alternative methods described. ##STR26## 
     The reaction of Equation 1 is best carried out in an inert aprotic organic solvent such as dichloromethane, 1,2-dichloroethane, tetrahydrofuran, or acetonitrile, at a temperature between 20° and 85° C. The order of addition is not critical; however, it is often convenient to add the sulfonyl isocyanate or a solution of it in the reaction solvent, to a stirred suspension of the amine. 
     In some cases, the desired product is insoluble in the reaction solvent at ambient temperature and crystallizes from it in pure form. Products soluble in the reaction solvent are isolated by evaporation of the solvent. Compounds of Formula I then may be purified by trituration of the evaporation residue with solvents such as 1-chlorobutane or ethyl ether and filtration, by recrystallization from mixtures of solvents such as 1,2-dichloroethane, 1-chlorobutane and heptane or by chromatography on silica gel. 
     Sulfonyl isocyanates (II, W is O) can be prepared from the corresponding sulfonamides (IV) by one of the following two general methods. ##STR27## 
     The sulfonamide IV is reacted with an alkyl isocyanate (e.g., n-butyl isocyanate) in a solvent whose boiling point is above 135° C., such as xylene. The reaction can optionally be carried out in the presence of a catalytic amount of 1,4-diaza[2.2.2]bicyclooctane (DABCO). The reaction mixture is heated to 135°-140° C. and held at that temperature for 5-60 minutes, after which phosgene is slowly added at such a rate that the temperature remains between 133° and 135° C. When the consumption of phosgene has ceased, the mixture is cooled and filtered to remove insoluble material. Finally, the solvent, alkyl isocyanate, and excess phosgene are evaporated, leaving the sulfonyl isocyanate (II). 
     If desired, the alkyl isocyanate-sulfonamide adduct can be made and isolated before reaction with the phosgene. In this case the sulfonamide (IV), alkyl isocyanate, and anhydrous base (e.g. K 2  CO 3 ) or acetonitrile) are mixed and heated under reflux for 1 to 6 hours. The reaction mixture is then diluted with water, and the pH is adjusted to about 3 with acid (e.g. HCl, H 2  SO 4 ). The adduct is filtered out and dried, and then reacted with phosgene as described above. This procedure modification is especially useful with sulfonamide (IV) is high melting and has low solubility in the phosgenation solvent. 
     Sulfonyl isocyanates (II, W is O) can also be prepared by the following method. ##STR28## 
     The sulfonamide (IV) is heated at reflux in an excess of thionyl chloride. The reaction is continued until the sulfonamide protons are no longer detectable in the proton magnetic resonance spectrum. From 16 hours to 5 days is typically sufficient for complete conversion to the thionylamide (V) (Equation 3a). 
     The thionyl chloride is evaporated and the residue is treated with an inert solvent (e.g. toluene) containing at least one equivalent (typically 2-3 equivalents) of phosgene. A catalytic amount of pyridine (typically 0.1 equivalent) is added, and the mixture is heated to about 60°-140° C., with 80°-100° C. preferred. Conversion to the isocyanate (II, W is O) is usually substantially complete within 15 minutes to 3 hours (Equation 3b). The mixture is then cooled and filtered, and the solvent is evaporated, leaving the sulfonyl isocyanate (II, W is O). 
     Sulfonyl isothiocyanates (II, W is S) can be prepared from the corresponding sulfonamides (IV) by reaction with carbon disulfide and potassium hydroxide followed by treatment of the resulting dipotassium salt VI with phosgene. Such a procedure is described in Arch. Pharm., 299, 174 (1966). 
     Many of the compounds of Formula I can be prepared by the procedure shown in Equation 4. ##STR29## 
     The reaction of Equation 4 can be carried out by contacting phenylcarbamates or phenylthiocarbamates of Formula VI with aminoheterocycles of Formula III in an inert organic solvent such as dioxane or tetrahydrofuran at temperatures of about 20°-100° C. for a period of about one-half to twenty-four hours. The product can be isolated by evaporation of the reaction solvent and purified by methods previously described. 
     Phenylcarbamates and phenylthiocarbamates of Formula VI can be prepared by the methods described, or modifications thereof known to those skilled in the art, in U.S. Pat. No. 4,443,243. 
     Alternatively, many of the compounds of Formula I can be prepared by the method described in Equation 5. ##STR30## 
     The reaction of Equation 5 can be carried out by contacting equimolar amounts of a sulfonamide of Formula IV with a heterocyclic phenylcarbamate or phenylthiocarbamate of Formula VII in the presence of a base such as 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), by methods analogous to those described in South African Patent Application 83/0441. The phenylcarbamates and phenylthiocarbamates of Formula VII can be prepared by methods, or modifications thereof known to those skilled in the art, described in South African Patent Application 82/5671 and South African Patent Application 82/5045. 
     The sulfonamides IV of this invention may be prepared in a variety of ways some of which are described in Equations 6 through 15. 
     The sulfonamides IV of this invention can be prepared from the corresponding sulfonyl chloride of Formula VIII. The preparation of sulfonamides from sulfonyl chlorides is widely reported in the literature; for reviews see: F. Hawking and J. S. Lawrence. &#34;The Sulfonamides&#34;. H. K. Lewis and Co., London, 1950, and E. H. Northey, &#34;The Sulfonamides and Allied Compound&#34;, Reinhold Publishing Corp., New York, 1984. 
     
         L--SO.sub.2 Cl                                             VIII 
    
     The requisite sulfonyl chloride of Formula VIII may be synthesized from IX, X, or XI by known methods or with slight modification thereof, by one skilled in the art. ##STR31## wherein L is as previously defined. U is Cl, Br or I 
     L&#39; is L-1, L-2, L-3, L-4a, L-4b, L-5, L-6, L-7, L-10, L-11, L-12, L-13, L-19 or L-20. 
     Several representative teaching are listed below. 
     Aromatic nitro group may be transformed into sulfonyl chloride by reduction, diazotization and coupling with sulfur dioxide/cupric chloride as taught in U.S. Pat. No. 4,310,346. 
     European Publication No. 94,821 (published 11/23/83) describes the displacement of aromatic halide with thiolate anions and subsequent oxidative chlorination to yield sulfonyl chlorides. 
     Halogen metal exchange of aromatic halides or proton-metal exchange of aromatic followed by quenching with sulfur dioxide give sulfinate salts. 
     These salts yield sulfonyl chlorides upon reaction with N-chlorosuccinimide as taught in U.S. Pat. No. 4,481,029 (issued 11/6/84). 
     Directed proton-metal exchange of aromatic compounds has been reviewed by Gschweard and Rodriquez, Org. Reactions, 26, (1979). Also aryllithiums may be converted directly to arylsulfonyl chloride with sulfonyl chloride as described by S. N. Bhattacharya, et. al, in J. Chem. Soc. C., 1265 (1968). 
     Electrophilic chlorosulfonation of an aromatic ring to give a sulfonyl chloride is well known in the literature. Its application is described by E. H. Huntress, et al., in J. Am. Chem. Soc., 62, 511-14 and 603-4 (1940), and W. E. Kirkpatrick, et al., in J. Med. Chem., 20, 386 (1977). 
     The compounds of Formula XI, where L&#39; is L-1, L-2, L-3, L-4a, L-4b, L-5, L-6, L-7, L-10, L-11, L-12, L-13 L-19 or L-20, may be synthesized from compounds of Formula IX by nitration as taught by B. M. Lynch, et al., in Can. J. Chem., 53, 119 (1975), W. E. Kirkpatrick, et al., in J. Med. Chem., 20, 386 (1977) and B. Stanovnik in Lect. Heterocyclic. Chem., 2, 27. 
     The compounds of Formula IX 1 , can be synthesized by the methods shown below in Equation 6 through 10. ##STR32## wherein R 1 , R 2 , R 3  and Z are as previously defined. 
     Equation 6 illustrates the reaction of β-dicarbonyl compounds of Formula XII (or their equivalent) with an aminopyrazole of Formula XIII 1  to give the desired heterocycles of Formula IX 1  Z is CH, ##STR33## wherein R 1  is as previously defined, R 2&#39;   is H, C 1  -C 3  alkyl or C 1  -C 2  alkyl substituted with OCH 3 , SCH 3  or CN; R 3&#39;   is H or CH 3 . 
     The reaction of Equation 6 is best carried out under the conditions taught by W. E. Kirkpatrick, et al., in J. Med. Chem., 20, 386 (1977), J. S. Bajwa, et al., in J. Chem. Soc. Perkin I., 3085 (1979) and B. M. Lynch, et al., in Can. J. Chem., 53, 119 (1975). 
     Equation 7 illustrates the reaction of aminopyrazole of Formula XIII 1  with compounds of Formula XIV to give the desired heterocycles of Formula IX 1 , Z is N. ##STR34## wherein R 1 , R 2&#39; , and R 3&#39;   are as previously defined; and 
     R 36  is C 1  -C 4  alkyl. 
     The reaction of Equation 7 is best carried out in an inert solvent such as toluene in the presence of an acid such as p-toluenesulfonic acid at a temperature between about 0° C. to 111° C. The products may be isolated by washing the reaction solution with an aqueous sodium carbonate solution, drying (MgSO 4 ) and concentrating the reaction solution. Crystallization and chromatography may be used for further purification of the products. 
     Equation 8 illustrates the reaction of aminopyrazole of Formula XIII 1 , with an imidate of Formula XV to give the amidines of Formula XVI and the reaction of the amidines of Formula XVI with ortho esters of Formula XVII to give the desired heterocycles of Formula IX, Z is N. ##STR35## wherein R 1 , R 2&#39; , and R 3&#39;   and R 36  are as previously defined and 
     R 37  is C 1  -C 4  alkyl. 
     The reaction of Equation 8 is best carried out under the conditions taught by Keitara Senga, et al., in J. Med. Chem., 25, 243 (1982). 
     Compounds of Formula IX 1  (R 3  is OCH 3 ) can be prepared as shown below in Equation 9 by reaction of chlorosubstituted heterocycles of Formula XVIII with methoxides of Formula XIX. ##STR36## wherein R 1  and R 2  are as previously defined; M is Na or K. 
     The reaction of Equation 9 is best carried out in an inert solvent such as dimethylformamide or an alcohol. The products may be isolated by evaporating the reaction solution and washing the residue with water. Chromatography may be used for further purification of the products. 
     Compounds of Formula IX 1 , (R 2  is R 2&#34; ), can be prepared as shown below in Equation 10 by reacting chlorosubstituted heterocycles of Formula XX with nucleophiles of Formula  -  R 2&#34; . ##STR37## wherein R 1 , R 3 , and Z are as previously defined; R 2&#34;   is C 1  -C 3  alkoxy, or C 1  -C 2  haloalkoxy. 
     The reaction of Equation 10 is best carried out in an inert solvent such as dimethylformamide or an alcohol. The products can be isolated by evaporating the reaction solvent and washing the residue with water. Chromatography may be used for further purification of the products. 
     Compounds XVIII and XX can be prepared from dichloroheterocycles of Formula XXI by nucleophilic displacement reactions with an appropriate nucleophile by methods in the art or by obvious modifications of these known methods. ##STR38## wherein 
     Z and R 1  are as previously defined. 
     Alternatively, they can be prepared by reacting the corresponding hydroxy compounds of Formula XXII or XXIII with POCl 3  or by other well-known methods or by obvious modification of these known methods. ##STR39## wherein Z, R 1 , R 2  and R 3  are as previously defined. 
     Compounds XXI can be prepared by reacting the corresponding dihydroxy compounds of Formula XXIV with POCl 3  by methods well known in the art. ##STR40## wherein R 1  and Z are as previously defined. 
     The compounds XXII (Z is C--H). XXIII (Z is C--H) or XXIV (Z is C--H) can be prepared by condensation of a β-keto ester, a malonatediester or one of their equivalents with 3-amino-pyrazoles of Formula XIII, as taught by: 
     1. Yasuo Makisumi in Chem. Pharm. Bull., 10, 612 (1962); 
     2. Keitara Senga et al. in J. Med. Chem., 24 (5), 61a (1971); 
     3. Alfred Dornow and Klaus Dehmer in Chem. Ber., 100 (8), 2577 (1967); 
     4. Mohamed Elnagdi in Arch. Pharm., 316 (8), 713 (1983); 
     5. B. B. Gavrilenko in Zh. Org. Khim., 18 (5), 1079 (1982); 
     or by modifications of these methods (e.g., reaction of 3-amino-pyrazoles of Formula XIII, with diketene). 
     The compounds XXII (Z is N), XXIII (Z is N) or XXIV (Z is N) can be similarly prepared by condensation of carbonylisocyanates of Formula XXV or the compounds of Formula XXVI with aminopyrazoles of Formula XIII 1 . ##STR41## wherein J is H, Cl, CH 3 , C 1  -C 4  alkoxy, 
     R 2 , R 36  and R 37  are as previously defined. 
     The haloheterocycles of Formula X 1  can be synthesized by the same methods as those for the preparation of the heterocycles of Formula IX 1  using the aminohalopyrazoles of Formula XXVII 1  instead of the aminopyrazoles of Formula XIII 1  as starting material. ##STR42## wherein R 1 , R 2 , R 3 , U and Z are as previously defined. 
     Alternatively, the haloheterocycles of Formula X 1  can be synthesized by halogenation of the heterocycles of Formula IX 1  with a halogenating agent such as bromine, N-bromosuccinimide, chlorine, N-chlorosuccinimide or iodine as shown in Equation 11. ##STR43## wherein R 1 , R 2 , R 3 , Z and U are as previously defined. 
     The reaction of Equation 11 is best carried out in an inert solvent such as chloroform or carbon tetrachloride at a temperature between 0° C. to 77° C. The products can then be isolated by filtration, concentration of the filtrate and washing the residue with water. Crystallization or chromatography may be used for further purification if desired. 
     By similar methods as discussed for the preparation of the heterocycles of Formula IX 1  and the haloheterocycles of Formula X 1  from the aminopyrazoles of Formula XIII 1  and the aminohalopyrazoles of Formula XXVII 1 , following compounds can be prepared: 
     The heterocycles of Formula IX 2  and the haloheterocycles of Formula X 2  can be prepared from the amino triazoles of Formula XIII 2  and the aminohalotriazoles of Formula XXVII 2  ; 
     The heterocycles of Formula IX 3  and the haloheterocycles of Formula X 3  can be prepared from the aminoimidazoles of Formula XIII 3  and the aminohaloimidazoles of Formula XXVII 3  ; 
     The heterocycles of Formula IX 4  and the haloheterocycles of Formula X 4  can be prepared from the N-aminoazoles of Formula XIII 4  and the N-aminohaloazoles of Formula XXVII 4  ; 
     The heterocycles of Formula IX 5  (where Z 1  is CH or CCH 3 ) and the haloheterocycles of Formula X 5  can be prepared from the N-aminoazoles of Formula XIII 5  (where Z 1  is CH or CCH 3 ) and the N-aminohaloazoles of Formula XXVII 5 . ##STR44## wherein R 1 , R 2 , R 3 , R 4 , Z and N are as previously defined. 
     The haloheterocycles of Formula X 2 , X 3 , X 4 , and X 5 , can also be prepared by halogenation of the heterocycles of Formula IX 2 , IX 3 , IX 4  and IX 5 . 
     The heterocycles of Formula IX 4  (Z 1  is N,) can also be prepared by the reaction of compounds of Formula XXXXIII with orthoformate as shown below in Equation 12. ##STR45## wherein R 2 , R 3  and Z are as previously defined and 
     R is lower alkyl. 
     The reaction of Equation 12 is best carried out in an inert solvent such as toluene at a temperature between about 0° C. to 120° C. The product can be isolated by evaporation of the reaction solvent and orthoformate. Crystallization of chromatography may be used for further purification of the products. 
     The heterocycles of Formula IX 5  (Z 1  is N,) can be prepared by the reaction of compounds of Formula XXXXIV with an α-halocarbonyl compound of Formula XXXXV as shown in Equation 13. ##STR46## wherein R 1 , R 2 , R 3 , Z and V are as previously defined. 
     The reaction of Equation 13 is best carried out in an inert solvent such as N,N-dimethylformamide at a temperature between about 0° C. to 160° C. The products can be isolated by evaporation of the reaction solvent and washing the residue with other solvent such as hexane or ether. Crystallization or chromatography may be used for further purification, if desired. 
     The heterocycles of Formula IX 6  can be prepared from compounds of Formula XXVIII. For example, reaction of some of the compounds of Formula XXVIII with 2,3-butadione gives the desired products of Formula IX 6  (R 2  is CH 3 , R 3  is CH 3 ) as shown below in Equation 14. ##STR47## wherein R 2 , R 3 , and R 4  are as previously defined. ##STR48## wherein R 4  is as previously defined. 
     The reaction of Equation 14 is best carried out in an inert solvent such as toluene in the presence of an acid catalyst such as p-toluenesulfonic acid, if necessary, at a temperature between 0° C. and 120° C. The products may be isolated by evaporation of solvent, followed by chromatography or recrystallization of the residue. 
     The haloheterocycles of Formula X 6  can be synthesized by the same method as those for the preparation of the heterocycles of Formula IX 6  using the halocompounds of Formula XXIX instead of the compounds of Formula XXVIII as starting material. ##STR49## wherein R 2 , R 3 , R 4  and U are as previously defined. 
     Alternatively the haloheterocycles of Formula X 6  can be prepared by halogenation of the heterocycles of Formula IX 6  with a halogenating agent such as bromine, N-bromosuccinimide, chlorine, N-chlorosuccinimide or iodine. 
     The heterocycles of Formula IX 7  and the haloheterocycles of Formula X 7  can be synthesized from compounds of Formula XXX and Formula XXXI by the same methods as those for the preparation of compounds of Formula IX 6  and X 6  from compounds of Formula XXVIII and Formula XXIX. ##STR50## wherein R 1 , R 2 , R 3 , R 4  and U are as previously defined. 
     The heterocycles of Formula IX 19  can be synthesized from the aminoheterocycles of Formula XXXII by similar methods as discussed for the preparation of the heterocycles of Formula IX 1  from aminopyrazole of Formula XIII 1 . For example, reaction of the aminoheterocycles of Formula XXXII with a β-dicarbonyl compound of Formula XXII should give the desired heterocycles of Formula IX 19  (R 2  is R 2&#39; , R 3  is R 3&#39;  and Z is C-H) as shown below in Equation 15. ##STR51## wherein R 2&#39; , R 3&#39; , and Z 2  are as previously defined. 
     The reaction of Equation 15 is best carried out under the conditions taught by A. Z. Britten, et al. in Chem. Ind., 6, 278 (1973). 
     Reaction of compounds of Formula XXXIII with HCO 2  NH 4  gives the desired heterocycles of Formula IX 19  (Z is N, R 2  is CH 3 , R 3  is CH 3 ) as shown in Equation 16. ##STR52## 
     The reaction of Equation 14 is best carried out under the conditions taught by Guy Ah-Kon, et al., in C. R. Acad. Sci., Ser. C., 278 (26), 1513 (1974). 
     The haloheterocycles of Formula X 19  can be synthesized from starting materials such as compounds of Formula XXXIV and XXXV in the same way as for the preparation of the heterocycles of Formula IX 19  from compounds of Formula XXXII and Formula XXXIII. Alternatively, compounds of Formula IX 19  can be converted to the haloheterocycles of Formula X 19  by halogenation. 
     The haloheterocycles of Formula X 20  can be prepared from starting materials such as compounds of Formula XXXVI and formula XXXVII by similar chemistry as taught previously for the preparation of heterocycles of Formula IX 19 . 
     The heterocycles of Formula IX 20  can be synthesized by dehalogenating the haloheterocycles of Formula X 20 . ##STR53## wherein R 2 , R 3 , Z, Z 3  and U are as previously defined. 
     The haloheterocycles of Formula X 14  can be prepared from compounds of Formula XXXVIII. For example, reaction of compounds of Formula XXXVIII with triethylorthoacetate gives the desired haloheterocycles of Formula X 14  (R 2  is CH 3 ) as shown in Equation 17. ##STR54## wherein R 1 , R 4 , and U are as previously defined. 
     The reaction of Equation 17 is best carried out in an inert solvent such as acetic acid at a temperature between 20° C. to 118° C. The products may be isolated by evaporation of the solvent, followed by chromatography or crystallization of the residue. 
     By similar methods as those described for the preparation of haloheterocycles of Formula X 14  from compounds of Formula XXXVIII, the following haloheterocycles can be prepared: 
     The haloheterocycles of Formula X 15  can be prepared from compounds of Formula XXXIX. 
     The haloheterocycles of Formula X 16  can be prepared from compounds of Formula XXXX. 
     The haloheterocycles of Formula X 17  can be prepared from compounds of Formula XXXXI. 
     The haloheterocycles of Formula X 18  can be prepared from the compounds of Formula XXXXII. ##STR55## wherein R 1 , R 2 , R 4 , Z 1  and U are as previously defined. 
     Heterocycles of Formula IX 10  can be synthesized by literature methods (or by modification of these methods) such as those taught by: 
     T. Tsuchiya, et al., in Chem. Pharm. Bull., 31, 4568 (1983). 
     A. Kakehi, et al., in J. Org. Chem., 42, 443 (1977). 
     T. Tsuchiya, et al., in J. Chem. Soc., Chem. Commun., 1109 (1980). 
     A. Ohsawa, et al., in J. Org. Chem., 47, 3497 (1982). 
     D. E. Kuhla, et al., in &#34;Adv. Heterocycle Chem.&#34;, 21, 1-63 (1977). 
     U. Burger, et al., in Helv. Chim. Acta., 62, 540 (1975). 
     A. Kakehi, et al., in J. Org. Chem., 43, 4837 (1978). 
     G. Maury, et al., in Chem. Heterocycl. Compd., 30, 179 (1977). 
     H. L. Blewitt in Chem. Heterocycl. Compd., 30, 117 (1977). 
     T. Uchida, et al., in Synthesis, 209 (1976) 
     E. Kranz, et al., in Ger. Offen. 2220186 (published Nov. 8, 1973), Ger. Offen. 2058500 (published May 31, 1972) and in Chem. Ber., 105 (1972) 
     The haloheterocycles of Formula X 10  can be synthesized by halogenating the heterocycles of Formula IX 10  with halogenating agents. ##STR56## wherein R 1 , R 2 , R 3 , R 5 , Z, Z 1  and U are as previously defined. 
     The heterocycles of Formula IX 11  can be synthesized by literature methods (or by modification of these methods) such as those taught by K. Kasuga, et al., in Yakugaka Zasshi., 94, 952 (1974), M. Muehlstaedt, et al., in J. Prakt. Chem., 311, 363 (1969), and D. E. Kuhla, et al., in Adv. Heterocycl. Chem., 21, (1977). 
     Jpn. Kokai 84/2053801 also describes the synthesis of some heterocycles of Formula IX 11 . The haloheterocycles of Formula X 11  can be prepared by halogenating the heterocycles of Formula IX 11  ##STR57## wherein R 1 , R 3 , Rhu 5, Z 1  and U are as previously defined. 
     The heterocycles of Formula IX 12  can be synthesized by literature methods (or by modification of these methods) such as those taught by G. Maury, et al., in J. Heterocycl. Chem., 15, 1041 (1978), C. Wentrup in Helv. Chim. Acta., 61, 1755 (1978), S. Mineo, et al., in Synth. Commun., 6, 69 (1976) and Y. Tamura, et al., in J. Heterocycl. Chem., 12, 481 (1975). 
     X 12  can be prepared by halogenation of the heterocycles of Formula IX 12  with halogenating agents. ##STR58## 
     Heterocycles of Formula IX 13  can be synthesized by literature methods (or by modification of these methods) such as those taught by G. Maury, et al., in Bull. Soc., Chim. Belg., 91, 153 (1982) and C. Wentrup in Helv. Chim. Acta., 61, 1755 (1978). The haloheterocycles of Formula X 13  can be prepared by halogenation of the heterocycles of Formula IX 13 . ##STR59## 
     The intermediates of Formula XII, XIII 1 , XIV, XV, XXV, XXVI, XXVII 1 , XIII 2 , XIII 3 , XXVII 3 , XIII 4 , XXVII 4 , XIII 5 , XXVII 5 , XXVIII, XXIX, XXX, XXXI, XXXII, XXXIII, XXXIV, XXXV, XXXVI, XXXVII, XXXVIII, XXXIX, XXXX, XXXXI, XXXXII, XXXXIII, XXXXIV and XXXXV can be prepared by methods known in the art or by obvious modification of these known methods. 
     The synthesis of heterocyclic amines such as those represented by Formula III has been reviewed in &#34;The Chemistry of Heterocyclic Compounds,&#34; a series published by Interscience Publ., New York and London. Aminopyrimidines are described by D. J. Brown in &#34;The Pyrimidines,&#34; Vol. XVI of the series mentioned above which is herein incorporated by reference. The 2-amino-1,3,5-triazines of Formula III, where A is A-1 and Z 4  is N, can be prepared according to methods described by E. M. Smolin and L. Rappaport in &#34;s-Triazines and Derivatives,&#34; Vol. XIII. 
     Pyrimidines of Formula III, where A is A-1 and Y is an acetal or thioacetal substituent, can be prepared by methods taught in European Patent Application No. 84,224 (published July 27, 1983). 
     Pyrimidines of Formula III, where A is A-1 and Y is cyclopropyl or OCF 2  H can be synthesized according to the methods taught in U.S. Pat. No. 4,515,626 and U.S. Pat. No. 4,540,782, respectively. 
     Compounds of Formula III, where A is A-2 or A-3,  can be prepared by procedures disclosed in U.S. Pat. No. 4,339,267. 
     Compounds of Formula III, where A is A-4, can be prepared by methods taught in U.S. Pat. No. 4,487,626. 
     Additional references dealing with the synthesis ob bicyclic pyrimidines of Formula III, where A is A-2, A-3, or A-4 are Braker, Sheehan, Spitzmiller and Lott, J. Am. Chem. Soc., 69, 3072 (1947); Mitler and Bhattacharya, Quart. J. Indian Chem. Soc., 4, 152 (1927); Shrage and Hitchings, J. Org. Chem., 16, 1153  (1951); Caldwell, Kornfeld annd Donnell, J. Am. Chem. Soc., 63, 2188 (1941); and Fissekis, Myles and Brown, J. Org. Chem., 29, 2670 (1964). 
     Compounds of Formula III, where A is A-5, can be prepared by methods taught in the U.S. Pat. No. 4,421,550. 
     Compounds of Formula III, where A is A-6, can be prepared by methods taught in the U.S. Pat. No. 4,496,392. ##STR60## 
     
                       TABLE 1                                                     
______________________________________                                    
General Formula 1                                                         
R.sup.1   R.sup.2                                                         
                 R.sup.3                                                  
                        R     X     Y      Z.sup.4                        
______________________________________                                    
H         CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
H         CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
H         CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     Cl    OCH.sub.3                             
                                           CH                             
H         CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     CH.sub.3                                    
                                    CH.sub.3                              
                                           CH                             
H         CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
H         CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
H         CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OC.sub.2 H.sub.5                            
                                    NHCH.sub.3                            
                                           N                              
H         CH.sub.3                                                        
                 CH.sub.3                                                 
                        CH    OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
Cl        CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
Cl        CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
Cl        CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     Cl    OCH.sub.3                             
                                           CH                             
Cl        CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     CH.sub.3                                    
                                    CH.sub.3                              
                                           CH                             
Cl        CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
Cl        CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
Cl        CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OC.sub.2 H.sub.5                            
                                    NHCH.sub.3                            
                                           N                              
Cl        CH.sub.3                                                        
                 CH.sub.3                                                 
                        CH.sub.3                                          
                              OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     Cl    OCH.sub.3                             
                                           CH                             
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     CH.sub.3                                    
                                    CH.sub.3                              
                                           CH                             
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OC.sub.2 H.sub.5                            
                                    NHCH.sub.3                            
                                           N                              
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        CH.sub.3                                          
                              OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
SO.sub.2 N(CH.sub.3).sub.2                                                
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
SO.sub.2 N(CH.sub.3).sub.2                                                
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
SO.sub.2 N(CH.sub.3).sub.2                                                
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     Cl    OCH.sub.3                             
                                           CH                             
SO.sub.2 N(CH.sub.3).sub.2                                                
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
SO.sub.2 N(CH.sub.3).sub.2                                                
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
H         H      H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
H         H      H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
H         H      H      H     Cl    OCH.sub.3                             
                                           CH                             
H         H      H      H     CH.sub.3                                    
                                    CH.sub.3                              
                                           CH                             
H         H      H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
H         H      H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
H         H      H      H     OC.sub.2 H.sub.5                            
                                    NHCH.sub.3                            
                                           N                              
H         H      H      CH.sub.3                                          
                              OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
Cl        H      H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
Cl        H      H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
Cl        H      H      H     Cl    OCH.sub.3                             
                                           CH                             
Cl        H      H      H     CH.sub.3                                    
                                    CH.sub.3                              
                                           CH                             
Cl        H      H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
Cl        H      H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
Cl        H      H      H     OC.sub.2 H.sub.5                            
                                    NHCH.sub.3                            
                                           N                              
Cl        H      H      CH.sub.3                                          
                              OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
SO.sub.2 CH.sub.3                                                         
          H      H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
SO.sub.2 CH.sub.3                                                         
          H      H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
SO.sub.2 CH.sub.3                                                         
          H      H      H     Cl    OCH.sub.3                             
                                           CH                             
SO.sub.2 CH.sub.3                                                         
          H      H      H     CH.sub.3                                    
                                    CH.sub.3                              
                                           CH                             
SO.sub.2 CH.sub.3                                                         
          H      H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
SO.sub.2 CH.sub.3                                                         
          H      H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
SO.sub.2 CH.sub.3                                                         
          H      H      H     OC.sub.2 H.sub.5                            
                                    NHCH.sub.3                            
                                           N                              
SO.sub.2 CH.sub.3                                                         
          H      H      CH.sub.3                                          
                              OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
SO.sub.2 N(CH.sub.3).sub.2                                                
          H      H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
SO.sub.2 N(CH.sub.3).sub.2                                                
          H      H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
SO.sub.2 N(CH.sub.3).sub.2                                                
          H      H      H     Cl    OCH.sub.3                             
                                           CH                             
SO.sub.2 N(CH.sub.3).sub.2                                                
          H      H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
SO.sub.2 N(CH.sub.3).sub.2                                                
          H      H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
H         H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
H         H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
H         H      CH.sub.3                                                 
                        H     Cl    OCH.sub.3                             
                                           CH                             
H         H      CH.sub.3                                                 
                        H     CH.sub.3                                    
                                    CH.sub.3                              
                                           CH                             
H         H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
H         H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
H         H      CH.sub.3                                                 
                        H     OC.sub.2 H.sub.5                            
                                    NHCH.sub.3                            
                                           N                              
H         H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub. 3                             
                                           N                              
Cl        H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
Cl        H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
Cl        H      CH.sub.3                                                 
                        H     Cl    OCH.sub.3                             
                                           CH                             
Cl        H      CH.sub.3                                                 
                        H     CH.sub.3                                    
                                    CH.sub.3                              
                                           CH                             
Cl        H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
Cl        H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
Cl        H      CH.sub.3                                                 
                        H     OC.sub.2 H.sub.5                            
                                    NHCH.sub.3                            
                                           N                              
Cl        H      CH.sub.3                                                 
                        CH.sub.3                                          
                              OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        H     Cl    OCH.sub.3                             
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        H     CH.sub.3                                    
                                    CH.sub.3                              
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        H     OC.sub.2 H.sub.5                            
                                    NHCH.sub.3                            
                                           N                              
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        CH.sub.3                                          
                              OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
SO.sub.2 N(CH.sub.3).sub.2                                                
          H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
SO.sub.2 N(CH.sub.3).sub.2                                                
          H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
SO.sub.2 N(CH.sub.3).sub.2                                                
          H      CH.sub.3                                                 
                        H     Cl    OCH.sub.3                             
                                           CH                             
SO.sub.2 N(CH.sub.3).sub.2                                                
          H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
SO.sub.2 N(CH.sub.3).sub.2                                                
          H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
H         CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
H         CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
H         CH.sub.3                                                        
                 H      H     Cl    OCH.sub.3                             
                                           CH                             
H         CH.sub.3                                                        
                 H      H     CH.sub.3                                    
                                    CH.sub.3                              
                                           CH                             
H         CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
H         CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
H         CH.sub.3                                                        
                 H      H     OC.sub.2 H.sub.5                            
                                    NHCH.sub.3                            
                                           N                              
H         CH.sub.3                                                        
                 H      CH.sub.3                                          
                              OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
Cl        CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
Cl        CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
Cl        CH.sub.3                                                        
                 H      H     Cl    OCH.sub.3                             
                                           CH                             
Cl        CH.sub.3                                                        
                 H      H     CH.sub.3                                    
                                    CH.sub.3                              
                                           CH                             
Cl        CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
Cl        CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
Cl        CH.sub.3                                                        
                 H      H     OC.sub.2 H.sub.5                            
                                    NHCH.sub.3                            
                                           N                              
Cl        CH.sub.3                                                        
                 H      CH.sub.3                                          
                              OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 H      H     Cl    OCH.sub.3                             
                                           CH                             
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 H      H     CH.sub.3                                    
                                    CH.sub.3                              
                                           CH                             
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 H      H     OC.sub.2 H.sub.5                            
                                    NHCH.sub.3                            
                                           N                              
SO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 H      CH.sub.3                                          
                              OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
SO.sub.2 N(CH.sub.3).sub.2                                                
          CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
SO.sub.2 N(CH.sub.3).sub.2                                                
          CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
SO.sub.2 N(CH.sub.3).sub.2                                                
          CH.sub.3                                                        
                 H      H     Cl    OCH.sub.3                             
                                           CH                             
SO.sub.2 N(CH.sub.3).sub.2                                                
          CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
SO.sub.2 N(CH.sub.3).sub.2                                                
          CH.sub. 3                                                       
                 H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
CO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     Cl    OCH.sub.3                             
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     CH.sub.3                                    
                                    CH.sub.3                              
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
CO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
CO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        H     OC.sub.2 H.sub.5                            
                                    NHCH.sub.3                            
                                           N                              
CO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 CH.sub.3                                                 
                        CH.sub.3                                          
                              OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
CO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 H      H     Cl    OCH.sub.3                             
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 H      H     CH.sub.3                                    
                                    CH.sub.3                              
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
CO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 H      H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
CO.sub. 2 CH.sub.3                                                        
          CH.sub.3                                                        
                 H      H     OC.sub.2 H.sub.5                            
                                    NHCH.sub.3                            
                                           N                              
CO.sub.2 CH.sub.3                                                         
          CH.sub.3                                                        
                 H      CH.sub.3                                          
                              OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        H     Cl    OCH.sub.3                             
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        H     CH.sub.3                                    
                                    CH.sub.3                              
                                           CH                             
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    OCH.sub.3                             
                                           N                              
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        H     OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        H     OC.sub.2 H.sub.5                            
                                    NHCH.sub.3                            
                                           N                              
CO.sub.2 CH.sub.3                                                         
          H      CH.sub.3                                                 
                        CH.sub.3                                          
                              OCH.sub.3                                   
                                    CH.sub.3                              
                                           N                              
______________________________________                                    
 
    
     
                       TABLE 2                                                     
______________________________________                                    
General Formula 2                                                         
Z     R.sup.2 R.sup.3 R     X      Y       Z.sup.4                        
______________________________________                                    
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           CH                             
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           CH                             
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      H     Cl     OCH.sub.3                              
                                           CH                             
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      H     CH.sub.3                                      
                                   CH.sub.3                               
                                           CH                             
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           N                              
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OC.sub.2 H.sub.5                              
                                   NHCH.sub.3                             
                                           N                              
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      CH.sub.3                                            
                            OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           CH                             
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           CH                             
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      H     Cl     OCH.sub.3                              
                                           CH                             
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      H     CH.sub.3                                      
                                   CH.sub.3                               
                                           CH                             
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           N                              
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OC.sub.2 H.sub.5                              
                                   NHCH.sub.3                             
                                           N                              
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      CH.sub.3                                            
                            OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
CH    CH.sub.3                                                            
              H       H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           CH                             
CH    CH.sub.3                                                            
              H       H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           CH                             
CH    CH.sub.3                                                            
              H       H     Cl     OCH.sub.3                              
                                           CH                             
CH    CH.sub.3                                                            
              H       H     CH.sub.3                                      
                                   CH.sub.3                               
                                           CH                             
CH    CH.sub.3                                                            
              H       H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           N                              
CH    CH.sub.3                                                            
              H       H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
CH    CH.sub.3                                                            
              H       H     OC.sub.2 H.sub.5                              
                                   NHCH.sub.3                             
                                           N                              
CH    CH.sub.3                                                            
              H       CH.sub.3                                            
                            OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
N     CH.sub.3                                                            
              H       H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           CH                             
N     CH.sub.3                                                            
              H       H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           CH                             
N     CH.sub.3                                                            
              H       H     Cl     OCH.sub.3                              
                                           CH                             
N     CH.sub.3                                                            
              H       H     CH.sub.3                                      
                                   CH.sub.3                               
                                           CH                             
N     CH.sub.3                                                            
              H       H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           N                              
N     CH.sub.3                                                            
              H       H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
N     CH.sub.3                                                            
              H       H     OC.sub.2 H.sub.5                              
                                   NHCH.sub.3                             
                                           N                              
N     CH.sub.3                                                            
              H       CH.sub.3                                            
                            OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
CH    H       CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           CH                             
CH    H       CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           CH                             
CH    H       CH.sub. 3                                                   
                      H     Cl     OCH.sub.3                              
                                           CH                             
CH    H       CH.sub.3                                                    
                      H     CH.sub.3                                      
                                   CH.sub.3                               
                                           CH                             
CH    H       CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           N                              
CH    H       CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
CH    H       CH.sub.3                                                    
                      H     OC.sub.2 H.sub.5                              
                                   NHCH.sub.3                             
                                           N                              
CH    H       CH.sub.3                                                    
                      CH.sub.3                                            
                            OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
N     H       CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           CH                             
N     H       CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           CH                             
N     H       CH.sub.3                                                    
                      H     Cl     OCH.sub.3                              
                                           CH                             
N     H       CH.sub.3                                                    
                      H     CH.sub.3                                      
                                   CH.sub.3                               
                                           CH                             
N     H       CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           N                              
N     H       CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
N     H       CH.sub.3                                                    
                      H     OC.sub.2 H.sub.5                              
                                   NHCH.sub.3                             
                                           N                              
N     H       CH.sub.3                                                    
                      CH.sub.3                                            
                            OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
CH    H       H       H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           CH                             
CH    H       H       H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           CH                             
CH    H       H       H     Cl     OCH.sub.3                              
                                           CH                             
CH    H       H       H     CH.sub.3                                      
                                   CH.sub.3                               
                                           CH                             
CH    H       H       H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           N                              
CH    H       H       H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
CH    H       H       H     OC.sub.2 H.sub.5                              
                                   NHCH.sub.3                             
                                           N                              
CH    H       H       CH.sub.3                                            
                            OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
N     H       H       H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           CH                             
N     H       H       H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           CH                             
N     H       H       H     Cl     OCH.sub.3                              
                                           CH                             
N     H       H       H     CH.sub.3                                      
                                   CH.sub.3                               
                                           CH                             
N     H       H       H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           N                              
N     H       H       H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
N     H       H       H     OC.sub.2 H.sub.5                              
                                   NHCH.sub.3                             
                                           N                              
N     H       H       CH.sub.3                                            
                            OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
______________________________________                                    
 
    
     
                       TABLE 3                                                     
______________________________________                                    
General Formula 3                                                         
R.sup.2 R.sup.3 R.sup.4                                                   
                       R     X     Y        Z.sup.4                       
______________________________________                                    
CH.sub.3                                                                  
        CH.sub.3                                                          
                H      H     OCH.sub.3                                    
                                   OCH.sub.3                              
                                            CH                            
CH.sub.3                                                                  
        CH.sub.3                                                          
                H      H     OCH.sub.3                                    
                                   CH.sub.3 CH                            
CH.sub.3                                                                  
        CH.sub.3                                                          
                H      H     Cl    OCH.sub.3                              
                                            CH                            
CH.sub.3                                                                  
        CH.sub.3                                                          
                H      H     CH.sub.3                                     
                                   CH.sub.3 CH                            
CH.sub.3                                                                  
        CH.sub.3                                                          
                H      H     OCH.sub.3                                    
                                   OCH.sub.3                              
                                            N                             
CH.sub.3                                                                  
        CH.sub.3                                                          
                H      H     OC.sub.2 H.sub.5                             
                                   NHCH.sub.3                             
                                            N                             
CH.sub.3                                                                  
        CH.sub.3                                                          
                H      CH.sub.3                                           
                             OCH.sub.3                                    
                                   CH.sub.3 N                             
CH.sub.3                                                                  
        H       H      H     OCH.sub.3                                    
                                   OCH.sub.3                              
                                            CH                            
CH.sub.3                                                                  
        H       H      H     OCH.sub.3                                    
                                   CH.sub.3 CH                            
CH.sub.3                                                                  
        H       H      H     Cl    OCH.sub.3                              
                                            CH                            
CH.sub.3                                                                  
        H       H      H     CH.sub.3                                     
                                   CH.sub.3 CH                            
CH.sub.3                                                                  
        H       H      H     OCH.sub.3                                    
                                   OCH.sub.3                              
                                            N                             
CH.sub.3                                                                  
        H       H      H     OCH.sub.3                                    
                                   CH.sub.3 N                             
CH.sub.3                                                                  
        H       H      H     OC.sub.2 H.sub.5                             
                                   NHCH.sub.3                             
                                            N                             
CH.sub.3                                                                  
        H       H      CH.sub.3                                           
                             OCH.sub.3                                    
                                   CH.sub.3 N                             
H       CH.sub.3                                                          
                H      H     OCH.sub.3                                    
                                   OCH.sub.3                              
                                            CH                            
H       CH.sub.3                                                          
                H      H     OCH.sub.3                                    
                                   CH.sub.3 CH                            
H       CH.sub.3                                                          
                H      H     Cl    OCH.sub.3                              
                                            CH                            
H       CH.sub.3                                                          
                H      H     CH.sub.3                                     
                                   CH.sub.3 CH                            
H       CH.sub.3                                                          
                H      H     OCH.sub.3                                    
                                   OCH.sub.3                              
                                            N                             
H       CH.sub.3                                                          
                H      H     OCH.sub.3                                    
                                   CH.sub.3 N                             
H       CH.sub.3                                                          
                H      H     OC.sub.2 H.sub.5                             
                                   NHCH.sub.3                             
                                            N                             
H       CH.sub.3                                                          
                H      CH.sub.3                                           
                             OCH.sub.3                                    
                                   CH.sub.3 N                             
H       H       H      H     OCH.sub.3                                    
                                   OCH.sub.3                              
                                            CH                            
H       H       H      H     OCH.sub.3                                    
                                   CH.sub.3 CH                            
H       H       H      H     Cl    OCH.sub.3                              
                                            CH                            
H       H       H      H     CH.sub.3                                     
                                   CH.sub.3 CH                            
H       H       H      H     OCH.sub.3                                    
                                   OCH.sub.3                              
                                            N                             
H       H       H      H     OCH.sub.3                                    
                                   CH.sub.3 N                             
H       H       H      H     OC.sub.2 H.sub.5                             
                                   NHCH.sub.3                             
                                            N                             
H       H       H      CH.sub.3                                           
                             OCH.sub.3                                    
                                   CH.sub.3 N                             
______________________________________                                    
 
    
     
                       TABLE 4a                                                    
______________________________________                                    
General Formula 4a                                                        
Z.sup.1                                                                   
      R.sup.2 R.sup.3 R     X     Y        Z.sup.4                        
______________________________________                                    
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                  OCH.sub.3                               
                                           CH                             
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                  CH.sub.3 CH                             
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      H     Cl    OCH.sub.3                               
                                           CH                             
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      H     CH.sub.3                                      
                                  CH.sub.3 CH                             
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                  OCH.sub.3                               
                                           N                              
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                  CH.sub.3 N                              
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OC.sub.2 H.sub.5                              
                                  NHCH.sub.3                              
                                           N                              
CH    CH.sub.3                                                            
              CH.sub.3                                                    
                      CH.sub.3                                            
                            OCH.sub.3                                     
                                  CH.sub.3 N                              
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                  OCH.sub.3                               
                                           CH                             
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                  CH.sub.3 CH                             
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      H     Cl    OCH.sub.3                               
                                           CH                             
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      H     CH.sub.3                                      
                                  CH.sub.3 CH                             
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                  OCH.sub.3                               
                                           N                              
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OCH.sub.3                                     
                                  CH.sub.3 N                              
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      H     OC.sub.2 H.sub.5                              
                                  NHCH.sub. 3                             
                                           N                              
N     CH.sub.3                                                            
              CH.sub.3                                                    
                      CH.sub.3                                            
                            OCH.sub.3                                     
                                  CH.sub.3 N                              
CH    H       H       H     OCH.sub.3                                     
                                  OCH.sub.3                               
                                           CH                             
CH    H       H       H     OCH.sub.3                                     
                                  CH.sub.3 CH                             
CH    H       H       H     Cl    OCH.sub.3                               
                                           CH                             
CH    H       H       H     CH.sub.3                                      
                                  CH.sub.3 CH                             
CH    H       H       H     OCH.sub.3                                     
                                  OCH.sub.3                               
                                           N                              
CH    H       H       H     OCH.sub.3                                     
                                  CH.sub.3 N                              
CH    H       H       H     OC.sub.2 H.sub.5                              
                                  NHCH.sub.3                              
                                           N                              
CH    H       H       CH.sub.3                                            
                            OCH.sub.3                                     
                                  CH.sub.3 N                              
N     H       H       H     OCH.sub.3                                     
                                  OCH.sub.3                               
                                           CH                             
N     H       H       H     OCH.sub.3                                     
                                  CH.sub.3 CH                             
N     H       H       H     Cl    OCH.sub.3                               
                                           CH                             
N     H       H       H     CH.sub.3                                      
                                  CH.sub.3 CH                             
N     H       H       H     OCH.sub.3                                     
                                  OCH.sub.3                               
                                           N                              
N     H       H       H     OCH.sub.3                                     
                                  CH.sub.3 N                              
N     H       H       H     OC.sub.2 H.sub.5                              
                                  NHCH.sub.3                              
                                           N                              
N     H       H       CH.sub.3                                            
                            OCH.sub.3                                     
                                  CH.sub.3 N                              
______________________________________                                    
 
    
     
                       TABLE 4b                                                    
______________________________________                                    
General Formula 4b                                                        
R.sup.2 R.sup.3 R        X     Y        Z.sup.4                           
______________________________________                                    
CH.sub.3                                                                  
        CH.sub.3                                                          
                H        OCH.sub.3                                        
                               OCH.sub.3                                  
                                        CH                                
CH.sub.3                                                                  
        CH.sub.3                                                          
                H        OCH.sub.3                                        
                               CH.sub.3 CH                                
CH.sub.3                                                                  
        CH.sub.3                                                          
                H        Cl    OCH.sub.3                                  
                                        CH                                
CH.sub.3                                                                  
        CH.sub.3                                                          
                H        CH.sub.3                                         
                               CH.sub.3 CH                                
CH.sub.3                                                                  
        CH.sub.3                                                          
                H        OCH.sub.3                                        
                               OCH.sub.3                                  
                                        N                                 
CH.sub.3                                                                  
        CH.sub.3                                                          
                H        OCH.sub.3                                        
                               CH.sub.3 N                                 
CH.sub.3                                                                  
        CH.sub.3                                                          
                H        OC.sub.2 H.sub.5                                 
                               NHCH.sub.3                                 
                                        N                                 
CH.sub.3                                                                  
        CH.sub.3                                                          
                CH.sub.3 OCH.sub.3                                        
                               CH.sub.3 N                                 
CH.sub.3                                                                  
        H       H        OCH.sub.3                                        
                               OCH.sub.3                                  
                                        CH                                
CH.sub.3                                                                  
        H       H        OCH.sub.3                                        
                               CH.sub.3 CH                                
CH.sub.3                                                                  
        H       H        Cl    OCH.sub.3                                  
                                        CH                                
CH.sub.3                                                                  
        H       H        CH.sub.3                                         
                               CH.sub.3 CH                                
CH.sub.3                                                                  
        H       H        OCH.sub.3                                        
                               OCH.sub.3                                  
                                        N                                 
CH.sub.3                                                                  
        H       H        OCH.sub.3                                        
                               CH.sub.3 N                                 
CH.sub.3                                                                  
        H       H        OC.sub.2 H.sub.5                                 
                               NHCH.sub.3                                 
                                        N                                 
CH.sub.3                                                                  
        H       CH.sub.3 OCH.sub.3                                        
                               CH.sub.3 N                                 
H       CH.sub.3                                                          
                H        OCH.sub.3                                        
                               OCH.sub.3                                  
                                        CH                                
H       CH.sub.3                                                          
                H        OCH.sub. 3                                       
                               CH.sub.3 CH                                
H       CH.sub.3                                                          
                H        Cl    OCH.sub.3                                  
                                        CH                                
H       CH.sub.3                                                          
                H        CH.sub.3                                         
                               CH.sub.3 CH                                
H       CH.sub.3                                                          
                H        OCH.sub.3                                        
                               OCH.sub.3                                  
                                        N                                 
H       CH.sub.3                                                          
                H        OCH.sub.3                                        
                               CH.sub.3 N                                 
H       CH.sub.3                                                          
                H        OC.sub.2 H.sub.5                                 
                               NHCH.sub.3                                 
                                        N                                 
H       CH.sub.3                                                          
                CH.sub.3 OCH.sub.3                                        
                               CH.sub.3 N                                 
H       H       H        OCH.sub.3                                        
                               OCH.sub.3                                  
                                        CH                                
H       H       H        OCH.sub.3                                        
                               CH.sub.3 CH                                
H       H       H        Cl    OCH.sub.3                                  
                                        CH                                
H       H       H        CH.sub.3                                         
                               CH.sub.3 CH                                
H       H       H        OCH.sub.3                                        
                               OCH.sub.3                                  
                                        N                                 
H       H       H        OCH.sub.3                                        
                               CH.sub.3 N                                 
H       H       H        OC.sub.2 H.sub.5                                 
                               NHCH.sub.3                                 
                                        N                                 
H       H       CH.sub.3 OCH.sub.3                                        
                               CH.sub.3 N                                 
______________________________________                                    
 
    
     
                                           TABLE 5                                 
__________________________________________________________________________
General Formula 5                                                         
Z.sup.1                                                                   
       R.sup.1     R.sup.2                                                
                          R.sup.3                                         
                                 R      X        Y        Z.sup.4         
__________________________________________________________________________
CH     H           CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     H           CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     H           CH.sub.3                                               
                          CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
CH     H           CH.sub.3                                               
                          CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
CH     H           CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     H           CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     H           CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     H           CH.sub.3                                               
                          CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     Cl          CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     Cl          CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     Cl          CH.sub.3                                               
                          CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
CH     Cl          CH.sub.3                                               
                          CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
CH     Cl          CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     Cl          CH.sub.3                                               
                          CH.sub. 3                                       
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     Cl          CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     Cl          CH.sub.3                                               
                          CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          CH.sub. 3                                       
                                 H      Cl       OCH.sub.3                
                                                          CH              
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     H           H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     H           H      H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     H           H      H      H      Cl       OCH.sub.3                
                                                          CH              
CH     H           H      H      H      CH.sub.3 CH.sub.3 CH              
CH     H           H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     H           H      H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     H           H      H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     H           H      H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     Cl          H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     Cl          H      H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     Cl          H      H      H      Cl       OCH.sub.3                
                                                          CH              
CH     Cl          H      H      H      CH.sub.3 CH.sub.3 CH              
CH     Cl          H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     Cl          H      H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     Cl          H      H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     Cl          H      H      CH.sub.3                                 
                                        OCH.sub. 3                        
                                                 CH.sub.3 N               
CH     SO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     SO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     SO.sub.2 CH.sub.3                                                  
                   H      H      H      Cl       OCH.sub.3                
                                                          CH              
CH     SO.sub.2 CH.sub.3                                                  
                   H      H      H      CH.sub.3 CH.sub.3 CH              
CH     SO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     SO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     SO.sub.2 CH.sub.3                                                  
                   H      H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     SO.sub.2 CH.sub.3                                                  
                   H      H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      H      H      Cl       OCH.sub.3                
                                                          CH              
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     H           H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     H           H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     H           H      CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
CH     H           H      CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
CH     H           H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     H           H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     H           H      CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     H           H      CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     Cl          H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     Cl          H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     Cl          H      CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
CH     Cl          H      CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
CH     Cl          H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     Cl          H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     Cl          H      CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     Cl          H      CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
CH     SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
CH     SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     H           CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     H           CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     H           CH.sub.3                                               
                          H      H      Cl       OCH.sub.3                
                                                          CH              
CH     H           CH.sub.3                                               
                          H      H      CH.sub.3 CH.sub.3 CH              
CH     H           CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     H           CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     H           CH.sub.3                                               
                          H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     H           CH.sub.3                                               
                          H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     Cl          CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     Cl          CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     Cl          CH.sub.3                                               
                          H      H      Cl       OCH.sub.3                
                                                          CH              
CH     Cl          CH.sub.3                                               
                          H      H      CH.sub.3 CH.sub.3 CH              
CH     Cl          CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     Cl          CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     Cl          CH.sub.3                                               
                          H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     Cl          CH.sub.3                                               
                          H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      Cl       OCH.sub.3                
                                                          CH              
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      CH.sub.3 CH.sub.3 CH              
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          H      H      Cl       OCH.sub.3                
                                                          CH              
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      H           CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      H           CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      H           CH.sub.3                                               
                          CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
N      H           CH.sub.3                                               
                          CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
N      H           CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      H           CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      H           CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      H           CH.sub.3                                               
                          CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      Cl          CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      Cl          CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      Cl          CH.sub.3                                               
                          CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
N      Cl          CH.sub.3                                               
                          CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
N      Cl          CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      Cl          CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      Cl          CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      Cl          CH.sub.3                                               
                          CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      H           H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      H           H      H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      H           H      H      H      Cl       OCH.sub.3                
                                                          CH              
N      H           H      H      H      CH.sub.3 CH.sub.3 CH              
N      H           H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      H           H      H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      H           H      H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      H           H      H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      Cl          H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      Cl          H      H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      Cl          H      H      H      Cl       OCH.sub.3                
                                                          CH              
N      Cl          H      H      H      CH.sub.3 CH.sub.3 CH              
N      Cl          H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      Cl          H      H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      Cl          H      H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      Cl          H      H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      SO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      SO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      SO.sub.2 CH.sub.3                                                  
                   H      H      H      Cl       OCH.sub.3                
                                                          CH              
N      SO.sub.2 CH.sub.3                                                  
                   H      H      H      CH.sub.3 CH.sub.3 CH              
N      SO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      SO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      SO.sub.2 CH.sub.3                                                  
                   H      H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      SO.sub.2 CH.sub.3                                                  
                   H      H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.                  
                                                          N               
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      H      H      Cl       OCH.sub.3                
                                                          CH              
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      H           H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      H           H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      H           H      CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
N      H           H      CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
N      H           H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      H           H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      H           H      CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      H           H      CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      Cl          H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      Cl          H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      Cl          H      CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
N      Cl          H      CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
N      Cl          H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      Cl          H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      Cl          H      CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      Cl          H      CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
N      SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
N      SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      SO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.                  
                                                          CH              
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      H           CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      H           CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      H           CH.sub.3                                               
                          H      H      Cl       OCH.sub.3                
                                                          CH              
N      H           CH.sub.3                                               
                          H      H      CH.sub.3 CH.sub.3 CH              
N      H           CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      H           CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      H           CH.sub.3                                               
                          H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      H           CH.sub.3                                               
                          H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      Cl          CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      Cl          CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      Cl          CH.sub.3                                               
                          H      H      Cl       OCH.sub.3                
                                                          CH              
N      Cl          CH.sub.3                                               
                          H      H      CH.sub.3 CH.sub.3 CH              
N      Cl          CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      Cl          CH.sub.3                                               
                          H      H      OCH.sub. 3                        
                                                 CH.sub.3 N               
N      Cl          CH.sub.3                                               
                          H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      Cl          CH.sub.3                                               
                          H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      Cl       OCH.sub.3                
                                                          CH              
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      CH.sub.3 CH.sub.3 CH              
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      SO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          H      H      Cl       OCH.sub.3                
                                                          CH              
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      SO.sub.2 N(CH.sub.3).sub.2                                         
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      Cl       OCH.sub.3                
                                                          CH              
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      CH.sub.3 CH.sub.3 CH              
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
CH     CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
CH     CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     CO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     CO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     CO.sub. 2 CH.sub.3                                                 
                   H      H      H      Cl       OCH.sub.3                
                                                          CH              
CH     CO.sub.2 CH.sub.3                                                  
                   H      H      H      CH.sub.3 CH.sub.3 CH              
CH     CO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     CO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     CO.sub.2 CH.sub.3                                                  
                   H      H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     CO.sub.2 CH.sub.3                                                  
                   H      H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   H      H      H      Cl       OCH.sub.3                
                                                          CH              
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   H      H      H      CH.sub.3 CH.sub.3 CH              
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   H      H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   H      H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
CH     CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      Cl       OCH.sub.3                
                                                          CH              
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      CH.sub.3 CH.sub.3 CH              
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      CO.sub.2 CH.sub.3                                                  
                   CH.sub.3                                               
                          H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.                  
                                                          CH              
N      CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
N      CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
N      CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      CO.sub.2 CH.sub.3                                                  
                   H      CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      CO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      CO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      CO.sub.2 CH.sub.3                                                  
                   H      H      H      Cl       OCH.sub.3                
                                                          CH              
N      CO.sub.2 CH.sub.3                                                  
                   H      H      H      CH.sub.3 CH.sub.3 CH              
N      CO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      CO.sub.2 CH.sub.3                                                  
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      CO.sub.2 CH.sub.3                                                  
                   H      H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      CO.sub.2 CH.sub.3                                                  
                   H      H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      CO.sub.2 C.sub.2 H.sub. 5                                          
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      CO.sub.2 C.sub.2 H.sub.5                                           
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      CO.sub.2 C.sub.2 H.sub.5                                           
                   H      H      H      Cl       OCH.sub.3                
                                                          CH              
N      CO.sub.2 C.sub.2 H.sub.5                                           
                   H      H      H      CH.sub.3 CH.sub.3 CH              
N      CO.sub.2 C.sub.2 H.sub.5                                           
                   H      H      H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      CO.sub.2 C.sub.2 H.sub.5                                           
                   H      H      H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      CO.sub.2 C.sub.2 H.sub.5                                           
                   H      H      H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      CO.sub.2 C.sub.2 H.sub.5                                           
                   H      H      CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
N      CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          CH              
N      CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 CH              
N      CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      Cl       OCH.sub.3                
                                                          CH              
N      CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      CH.sub.3 CH.sub.3 CH              
N      CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 OCH.sub.3                
                                                          N               
N      CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OCH.sub.3                         
                                                 CH.sub.3 N               
N      CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 H      OC.sub.2 H.sub.5                  
                                                 NHCH.sub.3               
                                                          N               
N      CO.sub.2 C.sub.2 H.sub.5                                           
                   CH.sub.3                                               
                          CH.sub.3                                        
                                 CH.sub.3                                 
                                        OCH.sub.3                         
                                                 CH.sub.3 N               
__________________________________________________________________________
 
    
     
                       TABLE 6                                                     
______________________________________                                    
General Formula 6                                                         
R.sup.2                                                                   
      R.sup.3 R.sup.4                                                     
                     R     X      Y       Z.sup.4                         
______________________________________                                    
CH.sub.3                                                                  
      CH.sub.3                                                            
              H      H     OCH.sub.3                                      
                                  OCH.sub.3                               
                                          CH                              
CH.sub.3                                                                  
      CH.sub.3                                                            
              H      H     OCH.sub.3                                      
                                  CH.sub.3                                
                                          CH                              
CH.sub.3                                                                  
      CH.sub.3                                                            
              H      H     Cl     OCH.sub.3                               
                                          CH                              
CH.sub.3                                                                  
      CH.sub.3                                                            
              H      H     CH.sub.3                                       
                                  CH.sub.3                                
                                          CH                              
CH.sub.3                                                                  
      CH.sub.3                                                            
              H      H     OCH.sub.3                                      
                                  OCH.sub.3                               
                                          N                               
CH.sub.3                                                                  
      CH.sub.3                                                            
              H      H     OCH.sub.3                                      
                                  CH.sub.3                                
                                          N                               
CH.sub.3                                                                  
      CH.sub.3                                                            
              H      H     OC.sub.2 H.sub.5                               
                                  NHCH.sub.3                              
                                          N                               
CH.sub.3                                                                  
      CH.sub.3                                                            
              H      CH.sub.3                                             
                           OCH.sub.3                                      
                                  CH.sub.3                                
                                          N                               
H     CH.sub.3                                                            
              H      H     OCH.sub.3                                      
                                  OCH.sub.3                               
                                          CH                              
H     CH.sub.3                                                            
              H      H     OCH.sub.3                                      
                                  CH.sub.3                                
                                          CH                              
H     CH.sub.3                                                            
              H      H     Cl     OCH.sub.3                               
                                          CH                              
H     CH.sub.3                                                            
              H      H     CH.sub.3                                       
                                  CH.sub.3                                
                                          CH                              
H     CH.sub.3                                                            
              H      H     OCH.sub.3                                      
                                  OCH.sub.3                               
                                          N                               
H     CH.sub.3                                                            
              H      H     OCH.sub.3                                      
                                  CH.sub.3                                
                                          N                               
H     CH.sub.3                                                            
              H      H     OC.sub.2 H.sub.5                               
                                  NHCH.sub.3                              
                                          N                               
H     CH.sub.3                                                            
              H      CH.sub. 3                                            
                           OCH.sub.3                                      
                                  CH.sub.3                                
                                          N                               
CH.sub.3                                                                  
      H       H      H     OCH.sub.3                                      
                                  OCH.sub.3                               
                                          CH                              
CH.sub.3                                                                  
      H       H      H     OCH.sub.3                                      
                                  CH.sub.3                                
                                          CH                              
CH.sub.3                                                                  
      H       H      H     Cl     OCH.sub.3                               
                                          CH                              
CH.sub.3                                                                  
      H       H      H     CH.sub.3                                       
                                  CH.sub.3                                
                                          CH                              
CH.sub.3                                                                  
      H       H      H     OCH.sub.3                                      
                                  OCH.sub.3                               
                                          N                               
CH.sub.3                                                                  
      H       H      H     OCH.sub.3                                      
                                  CH.sub.3                                
                                          N                               
CH.sub.3                                                                  
      H       H      H     OC.sub.2 H.sub.5                               
                                  NHCH.sub.3                              
                                          N                               
CH.sub.3                                                                  
      H       H      CH.sub.3                                             
                           OCH.sub.3                                      
                                  CH.sub.3                                
                                          N                               
H     H       H      H     OCH.sub.3                                      
                                  OCH.sub.3                               
                                          CH                              
H     H       H      H     OCH.sub.3                                      
                                  CH.sub.3                                
                                          CH                              
H     H       H      H     Cl     OCH.sub.3                               
                                          CH                              
H     H       H      H     CH.sub.3                                       
                                  CH.sub.3                                
                                          CH                              
H     H       H      H     OCH.sub.3                                      
                                  OCH.sub.3                               
                                          N                               
H     H       H      H     OCH.sub.3                                      
                                  CH.sub.3                                
                                          N                               
H     H       H      H     OC.sub.2 H.sub.5                               
                                  NHCH.sub.3                              
                                          N                               
H     H       H      CH.sub.3                                             
                           OCH.sub.3                                      
                                  CH.sub.3                                
                                          N                               
______________________________________                                    
 
    
     
                       TABLE 7                                                     
______________________________________                                    
General Formula 7                                                         
R.sup.4                                                                   
    R.sup.1    R.sup.2                                                    
                      R.sup.3                                             
                            R    X     Y      Z.sup.4                     
______________________________________                                    
H   H          CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   H          CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   H          CH.sub.3                                                   
                      CH.sub.3                                            
                            H    Cl    OCH.sub.3                          
                                              CH                          
H   H          CH.sub.3                                                   
                      CH.sub.3                                            
                            H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   H          CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   H          CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   H          CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OC.sub.2 H.sub.5                         
                                       NHCH.sub.3                         
                                              N                           
H   H          CH.sub.3                                                   
                      CH.sub.3                                            
                            CH.sub.3                                      
                                 OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   Cl         CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   Cl         CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   Cl         CH.sub.3                                                   
                      CH.sub.3                                            
                            H    Cl    OCH.sub.3                          
                                              CH                          
H   Cl         CH.sub.3                                                   
                      CH.sub.3                                            
                            H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   Cl         CH.sub.3                                                   
                      CH.sub. 3                                           
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   Cl         CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   Cl         CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OC.sub.2 H.sub.5                         
                                       NHCH.sub.3                         
                                              N                           
H   Cl         CH.sub.3                                                   
                      CH.sub.3                                            
                            CH.sub.3                                      
                                 OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   SO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   SO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   SO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    Cl    OCH.sub.3                          
                                              CH                          
H   SO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   SO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   SO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   SO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OC.sub.2 H.sub.5                         
                                       NHCH.sub.3                         
                                              N                           
H   SO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      CH.sub.3                                            
                            CH.sub.3                                      
                                 OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   SO.sub.2 N(CH.sub.3).sub.2                                            
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   SO.sub. 2 N(CH.sub.3).sub.2                                           
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   SO.sub.2 N(CH.sub.3).sub.2                                            
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    Cl    OCH.sub.3                          
                                              CH                          
H   SO.sub.2 N(CH.sub.3).sub.2                                            
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   SO.sub.2 N(CH.sub.3).sub.2                                            
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   H          H      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   H          H      H     H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   H          H      H     H    Cl    OCH.sub.3                          
                                              CH                          
H   H          H      H     H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   H          H      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   H          H      H     H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   H          H      H     H    OC.sub.2 H.sub.5                         
                                       NHCH.sub.3                         
                                              N                           
H   H          H      H     CH.sub.3                                      
                                 OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   Cl         H      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   Cl         H      H     H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   Cl         H      H     H    Cl    OCH.sub.3                          
                                              CH                          
H   Cl         H      H     H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   Cl         H      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   Cl         H      H     H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   Cl         H      H     H    OC.sub.2 H.sub.5                         
                                       NHCH.sub.3                         
                                              N                           
H   Cl         H      H     CH.sub.3                                      
                                 OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   SO.sub.2 CH.sub.3                                                     
               H      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   SO.sub.2 CH.sub.3                                                     
               H      H     H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   SO.sub.2 CH.sub.3                                                     
               H      H     H    Cl    OCH.sub.3                          
                                              CH                          
H   SO.sub.2 CH.sub.3                                                     
               H      H     H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   SO.sub.2 CH.sub.3                                                     
               H      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   SO.sub.2 CH.sub.3                                                     
               H      H     H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   SO.sub.2 CH.sub.3                                                     
               H      H     H    OC.sub.2 H.sub.5                         
                                       NHCH.sub.3                         
                                              N                           
H   SO.sub.2 CH.sub.3                                                     
               H      H     CH.sub.3                                      
                                 OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   SO.sub.2 N(CH.sub.3).sub.2                                            
               H      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   SO.sub.2 N(CH.sub.3).sub.2                                            
               H      H     H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   SO.sub.2 N(CH.sub.3).sub.2                                            
               H      H     H    Cl    OCH.sub.3                          
                                              CH                          
H   SO.sub.2 N(CH.sub. 3).sub.2                                           
               H      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   SO.sub.2 N(CH.sub.3).sub.2                                            
               H      H     H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   H          H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   H          H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   H          H      CH.sub.3                                            
                            H    Cl    OCH.sub.3                          
                                              CH                          
H   H          H      CH.sub.3                                            
                            H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   H          H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   H          H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   H          H      CH.sub.3                                            
                            H    OC.sub.2 H.sub.5                         
                                       NHCH.sub.3                         
                                              N                           
H   H          H      CH.sub.3                                            
                            CH.sub.3                                      
                                 OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   Cl         H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   Cl         H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   Cl         H      CH.sub.3                                            
                            H    Cl    OCH.sub.3                          
                                              CH                          
H   Cl         H      CH.sub.3                                            
                            H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   Cl         H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   Cl         H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   Cl         H      CH.sub.3                                            
                            H    OC.sub.2 H.sub.5                         
                                       NHCH.sub.3                         
                                              N                           
H   Cl         H      CH.sub.3                                            
                            CH.sub. 3                                     
                                 OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   SO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   SO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   SO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            H    Cl    OCH.sub.3                          
                                              CH                          
H   SO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   SO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   SO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   SO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            H    OC.sub.2 H.sub.5                         
                                       NHCH.sub.3                         
                                              N                           
H   SO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   SO.sub.2 N(CH.sub.3).sub.2                                            
               H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   SO.sub.2 N(CH.sub.3).sub.2                                            
               H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   SO.sub.2 N(CH.sub.3).sub.2                                            
               H      CH.sub.3                                            
                            H    Cl    OCH.sub.3                          
                                              CH                          
H   SO.sub.2 N(CH.sub.3).sub.2                                            
               H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   SO.sub.2 N(CH.sub.3).sub.2                                            
               H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   CO.sub. 2 CH.sub.3                                                    
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    Cl    OCH.sub.3                          
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   CO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   CO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OC.sub.2 H.sub.5                         
                                       NHCH.sub.3                         
                                              N                           
H   CO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      CH.sub.3                                            
                            CH.sub.3                                      
                                 OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   CO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      H     H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      H     H    Cl    OCH.sub.3                          
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      H     H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   CO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      H     H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   CO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      H     H    OC.sub.2 H.sub.5                         
                                       NHCH.sub.3                         
                                              N                           
H   CO.sub.2 CH.sub.3                                                     
               CH.sub.3                                                   
                      H     CH.sub.3                                      
                                 OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   CO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            H    Cl    OCH.sub.3                          
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   CO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   CO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            H    OC.sub.2 H.sub.5                         
                                       NHCH.sub.3                         
                                              N                           
H   CO.sub.2 CH.sub.3                                                     
               H      CH.sub.3                                            
                            CH.sub.3                                      
                                 OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   CO.sub.2 CH.sub.3                                                     
               H      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               H      H     H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               H      H     H    Cl    OCH.sub.3                          
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               H      H     H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   CO.sub.2 CH.sub.3                                                     
               H      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   CO.sub.2 CH.sub.3                                                     
               H      H     H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   CO.sub.2 CH.sub.3                                                     
               H      H     H    OC.sub.2 H.sub.5                         
                                       NHCH.sub.3                         
                                              N                           
H   CO.sub.2 CH.sub.3                                                     
               H      H     CH.sub.3                                      
                                 OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   CO.sub.2 C.sub.2 H.sub.5                                              
               H      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   CO.sub.2 C.sub.2 H.sub.5                                              
               H      H     H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   CO.sub.2 C.sub.2 H.sub.5                                              
               H      H     H    Cl    OCH.sub.3                          
                                              CH                          
H   CO.sub.2 C.sub.2 H.sub.5                                              
               H      H     H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   CO.sub.2 C.sub.2 H.sub.5                                              
               H      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   CO.sub.2 C.sub.2 H.sub.5                                              
               H      H     H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   CO.sub.2 C.sub.2 H.sub.5                                              
               H      H     H    OC.sub.2 H.sub.5                         
                                       NHCH.sub.3                         
                                              N                           
H   CO.sub.2 C.sub.2 H.sub.5                                              
               H      H     CH.sub.3                                      
                                 OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   CO.sub.2 C.sub.2 H.sub.5                                              
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   CO.sub.2 C.sub.2 H.sub.5                                              
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   CO.sub.2 C.sub.2 H.sub.5                                              
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    Cl    OCH.sub.3                          
                                              CH                          
H   CO.sub.2 C.sub.2 H.sub.5                                              
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   CO.sub.2 C.sub.2 H.sub.5                                              
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
H   CO.sub.2 C.sub.2 H.sub.5                                              
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   CO.sub.2 C.sub.2 H.sub.5                                              
               CH.sub.3                                                   
                      CH.sub.3                                            
                            H    OC.sub.2 H.sub.5                         
                                       NHCH.sub.3                         
                                              N                           
H   CO.sub.2 C.sub.2 H.sub.5                                              
               CH.sub.3                                                   
                      CH.sub.3                                            
                            CH.sub.3                                      
                                 OCH.sub.3                                
                                       CH.sub.3                           
                                              N                           
H   H          CH.sub.3                                                   
                      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              CH                          
H   H          CH.sub.3                                                   
                      H     H    OCH.sub.3                                
                                       CH.sub.3                           
                                              CH                          
H   H          CH.sub.3                                                   
                      H     H    Cl    OCH.sub.3                          
                                              CH                          
H   H          CH.sub.3                                                   
                      H     H    CH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
H   H          CH.sub.3                                                   
                      H     H    OCH.sub.3                                
                                       OCH.sub.3                          
                                              N                           
______________________________________                                    
 
    
     
                                           TABLE 8                                 
__________________________________________________________________________
General Formula 8                                                         
Z.sup.1                                                                   
    R.sup.1 R.sup.2                                                       
               R.sup.3                                                    
                  R.sup.5                                                 
                    R  X   Y     Z.sup.4                                  
__________________________________________________________________________
CH  H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
CH  H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
CH  H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  Cl  OCH.sub.3                                      
                                 CH                                       
CH  H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
CH  H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
CH  H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
CH  H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
CH  Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
CH  Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  Cl  OCH.sub.3                                      
                                 CH                                       
CH  Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
CH  Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
CH  Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
CH  Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  SO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
CH  SO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
CH  SO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  Cl  OCH.sub.3                                      
                                 CH                                       
CH  SO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
CH  SO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
CH  SO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  SO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
CH  SO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  SO.sub.2 N(CH.sub.3).sub.2                                            
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub. 3                                     
                                 CH                                       
CH  SO.sub.2 N(CH.sub.3).sub.2                                            
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
CH  SO.sub.2 N(CH.sub.3).sub.2                                            
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  Cl  OCH.sub.3                                      
                                 CH                                       
CH  SO.sub.2 N(CH.sub.3).sub.2                                            
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
CH  SO.sub.2 N(CH.sub.3).sub.2                                            
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
N   H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
N   H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  Cl  OCH.sub.3                                      
                                 CH                                       
N   H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
N   H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
N   H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
N   H       CH.sub.3                                                      
               CH.sub.3                                                   
                  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
N   Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
N   Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  Cl  OCH.sub.3                                      
                                 CH                                       
N   Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
N   Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
N   Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
N   Cl      CH.sub.3                                                      
               CH.sub.3                                                   
                  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   SO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
N   SO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
N   SO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  Cl  OCH.sub.3                                      
                                 CH                                       
N   SO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
N   SO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
N   SO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   SO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
N   SO.sub. 2 CH.sub.3                                                    
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   SO.sub.2 N(CH.sub.3).sub.2                                            
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
N   SO.sub.2 N(CH.sub.3).sub.2                                            
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
N   SO.sub.2 N(CH.sub.3).sub.2                                            
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  Cl  OCH.sub.3                                      
                                 CH                                       
N   SO.sub.2 N(CH.sub.3).sub.2                                            
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
N   SO.sub.2 N(CH.sub.3).sub.2                                            
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   H       H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
N   H       H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
N   H       H  H  H H  Cl  OCH.sub.3                                      
                                 CH                                       
N   H       H  H  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
N   H       H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
N   H       H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   H       H  H  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
N   H       H  H  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   Cl      H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
N   Cl      H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
N   Cl      H  H  H H  Cl  OCH.sub.3                                      
                                 CH                                       
N   Cl      H  H  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
N   Cl      H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
N   Cl      H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   Cl      H  H  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
N   Cl      H  H  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   SO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
N   SO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
N   SO.sub.2 CH.sub.3                                                     
            H  H  H H  Cl  OCH.sub.3                                      
                                 CH                                       
N   SO.sub.2 CH.sub.3                                                     
            H  H  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
N   SO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
N   SO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   SO.sub.2 CH.sub.3                                                     
            H  H  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
N   SO.sub.2 CH.sub.3                                                     
            H  H  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   SO.sub. 2 N(CH.sub.3).sub.2                                           
            H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
N   SO.sub.2 N(CH.sub.3).sub.2                                            
            H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
N   SO.sub.2 N(CH.sub.3).sub.2                                            
            H  H  H H  Cl  OCH.sub.3                                      
                                 CH                                       
N   SO.sub.2 N(CH.sub.3).sub.2                                            
            H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
N   SO.sub.2 N(CH.sub.3).sub.2                                            
            H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  H       H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
CH  H       H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
CH  H       H  H  H H  Cl  OCH.sub.3                                      
                                 CH                                       
CH  H       H  H  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
CH  H       H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
CH  H       H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  H       H  H  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
CH  H       H  H  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  Cl      H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
CH  Cl      H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
CH  Cl      H  H  H H  Cl  OCH.sub.3                                      
                                 CH                                       
CH  Cl      H  H  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
CH  Cl      H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
CH  Cl      H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  Cl      H  H  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
CH  Cl      H  H  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  SO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
CH  SO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
CH  SO.sub.2 CH.sub.3                                                     
            H  H  H H  Cl  OCH.sub.3                                      
                                 CH                                       
CH  SO.sub.2 CH.sub.3                                                     
            H  H  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
CH  SO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
CH  SO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  SO.sub.2 CH.sub.3                                                     
            H  H  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
CH  SO.sub.2 CH.sub.3                                                     
            H  H  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  SO.sub.2 N(CH.sub.3).sub.2                                            
            H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
CH  SO.sub.2 N(CH.sub.3).sub.2                                            
            H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
CH  SO.sub.2 N(CH.sub.3).sub.2                                            
            H  H  H H  Cl  OCH.sub.3                                      
                                 CH                                       
CH  SO.sub.2 N(CH.sub.3).sub.2                                            
            H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
CH  SO.sub.2 N(CH.sub.3).sub.2                                            
            H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
N   CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
N   CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  Cl  OCH.sub.3                                      
                                 CH                                       
N   CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
N   CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
N   CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
N   CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   CO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
N   CO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
N   CO.sub.2 CH.sub.3                                                     
            H  H  H H  Cl  OCH.sub.3                                      
                                 CH                                       
N   CO.sub.2 CH.sub.3                                                     
            H  H  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
N   CO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
N   CO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   CO.sub.2 CH.sub.3                                                     
            H  H  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
N   CO.sub.2 CH.sub.3                                                     
            H  H  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
CH  CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
CH  CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  Cl  OCH.sub.3                                      
                                 CH                                       
CH  CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
CH  CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
CH  CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
CH  CO.sub.2 CH.sub.3                                                     
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  CO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
CH  CO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
CH  CO.sub.2 CH.sub.3                                                     
            H  H  H H  Cl  OCH.sub.3                                      
                                 CH                                       
CH  CO.sub.2 CH.sub.3                                                     
            H  H  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
CH  CO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
CH  CO.sub.2 CH.sub.3                                                     
            H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
CH  CO.sub.2 CH.sub.3                                                     
            H  H  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
CH  CO.sub.2 CH.sub.3                                                     
            H  H  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   CO.sub.2 C.sub.2 H.sub.5                                              
            H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
N   CO.sub.2 C.sub.2 H.sub.5                                              
            H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
N   CO.sub.2 C.sub.2 H.sub.5                                              
            H  H  H H  Cl  OCH.sub.3                                      
                                 CH                                       
N   CO.sub.2 C.sub.2 H.sub.5                                              
            H  H  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
N   CO.sub.2 C.sub.2 H.sub.5                                              
            H  H  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
N   CO.sub.2 C.sub.2 H.sub.5                                              
            H  H  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   CO.sub.2 C.sub.2 H.sub.5                                              
            H  H  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
N   CO.sub.2 C.sub.2 H.sub.5                                              
            H  H  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   CO.sub.2 C.sub.2 H.sub.5                                              
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 CH                                       
N   CO.sub.2 C.sub.2 H.sub.5                                              
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 CH                                       
N   CO.sub.2 C.sub.2 H.sub.5                                              
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  Cl  OCH.sub.3                                      
                                 CH                                       
N   CO.sub.2 C.sub.2 H.sub.5                                              
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  CH.sub.3                                           
                           CH.sub.3                                       
                                 CH                                       
N   CO.sub.2 C.sub.2 H.sub.5                                              
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           OCH.sub.3                                      
                                 N                                        
N   CO.sub.2 C.sub.2 H.sub.5                                              
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
N   CO.sub.2 C.sub.2 H.sub.5                                              
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H H  OC.sub.2 H.sub.5                                   
                           NHCH.sub.3                                     
                                 N                                        
N   CO.sub.2 C.sub.2 H.sub.5                                              
            CH.sub.3                                                      
               CH.sub.3                                                   
                  H CH.sub.3                                              
                       OCH.sub.3                                          
                           CH.sub.3                                       
                                 N                                        
__________________________________________________________________________
 
    
     
                       TABLE 9                                                     
______________________________________                                    
General Formula 9                                                         
R.sup.1  R.sup.3                                                          
               R.sup.5    R    X     Y      Z.sup.4                       
______________________________________                                    
H        H     H          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            CH                            
H        H     H          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            CH                            
H        H     H          H    Cl    OCH.sub.3                            
                                            CH                            
H        H     H          H    CH.sub.3                                   
                                     CH.sub.3                             
                                            CH                            
H        H     H          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            N                             
H        H     H          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
H        H     H          H    OC.sub.2 H.sub.5                           
                                     NHCH.sub.3                           
                                            N                             
H        H     H          CH.sub.3                                        
                               OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
Cl       H     H          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            CH                            
Cl       H     H          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            CH                            
Cl       H     H          H    Cl    OCH.sub.3                            
                                            CH                            
Cl       H     H          H    CH.sub.3                                   
                                     CH.sub.3                             
                                            CH                            
Cl       H     H          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            N                             
Cl       H     H          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
Cl       H     H          H    OC.sub.2 H.sub.5                           
                                     NHCH.sub.3                           
                                            N                             
Cl       H     H          CH.sub.3                                        
                               OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
SO.sub.2 CH.sub.3                                                         
         H     H          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            CH                            
SO.sub.2 CH.sub.3                                                         
         H     H          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            CH                            
SO.sub.2 CH.sub.3                                                         
         H     H          H    Cl    OCH.sub.3                            
                                            CH                            
SO.sub.2 CH.sub.3                                                         
         H     H          H    CH.sub.3                                   
                                     CH.sub.3                             
                                            CH                            
SO.sub.2 CH.sub.3                                                         
         H     H          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            N                             
SO.sub.2 CH.sub.3                                                         
         H     H          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
SO.sub.2 CH.sub.3                                                         
         H     H          H    OC.sub.2 H.sub.5                           
                                     NHCH.sub.3                           
                                            N                             
SO.sub.2 CH.sub.3                                                         
         H     H          CH.sub.3                                        
                               OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
CO.sub.2 CH.sub.3                                                         
         H     H          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            CH                            
CO.sub.2 CH.sub.3                                                         
         H     H          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            CH                            
CO.sub.2 CH.sub.3                                                         
         H     H          H    Cl    OCH.sub.3                            
                                            CH                            
CO.sub.2 CH.sub.3                                                         
         H     H          H    CH.sub.3                                   
                                     CH.sub.3                             
                                            CH                            
CO.sub.2 CH.sub.3                                                         
         H     H          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            N                             
CO.sub.2 CH.sub.3                                                         
         H     H          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
CO.sub.2 CH.sub.3                                                         
         H     H          H    OC.sub.2 H.sub.5                           
                                     NHCH.sub.3                           
                                            N                             
CO.sub.2 CH.sub.3                                                         
         H     H          CH.sub.3                                        
                               OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
CO.sub.2 C.sub.2 H.sub.5                                                  
         H     H          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            CH                            
CO.sub.2 C.sub.2 H.sub.5                                                  
         H     H          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            CH                            
CO.sub.2 C.sub.2 H.sub.5                                                  
         H     H          H    Cl    OCH.sub.3                            
                                            CH                            
CO.sub.2 C.sub.2 H.sub.5                                                  
         H     H          H    CH.sub.3                                   
                                     CH.sub.3                             
                                            CH                            
CO.sub.2 C.sub.2 H.sub.5                                                  
         H     H          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            N                             
CO.sub.2 C.sub.2 H.sub.5                                                  
         H     H          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
CO.sub.2 C.sub.2 H.sub.5                                                  
         H     H          H    OC.sub.2 H.sub.5                           
                                     NHCH.sub.3                           
                                            N                             
CO.sub.2 C.sub.2 H.sub.5                                                  
         H     H          CH.sub.3                                        
                               OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
SO.sub.2 N(CH.sub.3).sub.2                                                
         H     H          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            CH                            
SO.sub.2 N(CH.sub.3).sub.2                                                
         H     H          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            CH                            
SO.sub.2 N(CH.sub.3).sub.2                                                
         H     H          H    Cl    OCH.sub.3                            
                                            CH                            
SO.sub.2 N(CH.sub.3).sub.2                                                
         H     H          H    CH.sub.3                                   
                                     CH.sub.3                             
                                            CH                            
SO.sub.2 N(CH.sub.3).sub.2                                                
         H     H          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            N                             
SO.sub.2 N(CH.sub.3).sub.2                                                
         H     H          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
SO.sub.2 N(CH.sub.3).sub.2                                                
         H     H          H    OC.sub.2 H.sub.5                           
                                     NHCH.sub.3                           
                                            N                             
SO.sub.2 N(CH.sub.3).sub.2                                                
         H     H          CH.sub. 3                                       
                               OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
H        H     H          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            CH                            
H        H     H          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            CH                            
H        H     H          H    Cl    OCH.sub.3                            
                                            CH                            
H        H     H          H    CH.sub.3                                   
                                     CH.sub.3                             
                                            CH                            
H        H     H          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            N                             
H        H     H          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
H        H     H          H    OC.sub.2 H.sub.5                           
                                     NHCH.sub.3                           
                                            N                             
H        H     H          CH.sub.3                                        
                               OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
H        H     Cl         H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            CH                            
H        H     Cl         H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            CH                            
H        H     Cl         H    Cl    OCH.sub.3                            
                                            CH                            
H        H     Cl         H    CH.sub.3                                   
                                     CH.sub.3                             
                                            CH                            
H        H     Cl         H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            N                             
H        H     Cl         H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
H        H     Cl         H    OC.sub.2 H.sub.5                           
                                     NHCH.sub.3                           
                                            N                             
H        H     Cl         CH.sub.3                                        
                               OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
H        H     SO.sub.2 CH.sub.3                                          
                          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            CH                            
H        H     SO.sub.2 CH.sub.3                                          
                          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            CH                            
H        H     SO.sub.2 CH.sub.3                                          
                          H    Cl    OCH.sub.3                            
                                            CH                            
H        H     SO.sub.2 CH.sub.3                                          
                          H    CH.sub.3                                   
                                     CH.sub.3                             
                                            CH                            
H        H     SO.sub.2 CH.sub.3                                          
                          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            N                             
H        H     SO.sub.2 CH.sub.3                                          
                          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
H        H     SO.sub.2 CH.sub.3                                          
                          H    OC.sub.2 H.sub.5                           
                                     NHCH.sub.3                           
                                            N                             
H        H     SO.sub.2 CH.sub.3                                          
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
H        H     CO.sub.2 CH.sub.3                                          
                          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            CH                            
H        H     CO.sub.2 CH.sub.3                                          
                          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            CH                            
H        H     CO.sub.2 CH.sub.3                                          
                          H    Cl    OCH.sub.3                            
                                            CH                            
H        H     CO.sub.2 CH.sub.3                                          
                          H    CH.sub.3                                   
                                     CH.sub.3                             
                                            CH                            
H        H     CO.sub.2 CH.sub.3                                          
                          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            N                             
H        H     CO.sub.2 CH.sub.3                                          
                          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
H        H     CO.sub.2 CH.sub.3                                          
                          H    OC.sub.2 H.sub.5                           
                                     NHCH.sub.3                           
                                            N                             
H        H     CO.sub.2 CH.sub.3                                          
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
H        H     CO.sub.2 C.sub.2 H.sub.5                                   
                          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            CH                            
H        H     CO.sub.2 C.sub.2 H.sub.5                                   
                          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            CH                            
H        H     CO.sub.2 C.sub.2 H.sub.5                                   
                          H    Cl    OCH.sub.3                            
                                            CH                            
H        H     CO.sub.2 C.sub.2 H.sub.5                                   
                          H    CH.sub.3                                   
                                     CH.sub.3                             
                                            CH                            
H        H     CO.sub.2 C.sub.2 H.sub.5                                   
                          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            N                             
H        H     CO.sub.2 C.sub.2 H.sub.5                                   
                          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
H        H     CO.sub.2 C.sub.2 H.sub.5                                   
                          H    OC.sub.2 H.sub.5                           
                                     NHCH.sub.3                           
                                            N                             
H        H     CO.sub.2 C.sub.2 H.sub.5                                   
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
H        H     SO.sub.2 N(CH.sub.3).sub.2                                 
                          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            CH                            
H        H     SO.sub.2 N(CH.sub.3).sub.2                                 
                          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            CH                            
H        H     SO.sub.2 N(CH.sub.3).sub.2                                 
                          H    Cl    OCH.sub.3                            
                                            CH                            
H        H     SO.sub.2 N(CH.sub.3).sub.2                                 
                          H    CH.sub.3                                   
                                     CH.sub.3                             
                                            CH                            
H        H     SO.sub.2 N(CH.sub.3).sub.2                                 
                          H    OCH.sub.3                                  
                                     OCH.sub.3                            
                                            N                             
H        H     SO.sub.2 N(CH.sub.3).sub.2                                 
                          H    OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
H        H     SO.sub.2 N(CH.sub.3).sub.2                                 
                          H    OC.sub.2 H.sub.5                           
                                     NHCH.sub.3                           
                                            N                             
H        H     SO.sub.2 N(CH.sub.3).sub.2                                 
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                     CH.sub.3                             
                                            N                             
______________________________________                                    
 
    
     
                       TABLE 10                                                    
______________________________________                                    
General Formula 10                                                        
Z    R.sup.2                                                              
           R.sup.3                                                        
                  R.sup.5  R    X      Y      Z.sup.4                     
______________________________________                                    
CH   H     H      H        H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              CH                          
CH   H     H      H        H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
CH   H     H      H        H    Cl     OCH.sub.3                          
                                              CH                          
CH   H     H      H        H    CH.sub.3                                  
                                       CH.sub.3                           
                                              CH                          
CH   H     H      H        H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              N                           
CH   H     H      H        H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
CH   H     H      H        H    OC.sub.2 H.sub.5                          
                                       NHCH.sub.3                         
                                              N                           
CH   H     H      H        CH.sub.3                                       
                                OCH.sub.3                                 
                                       CH     N                           
CH   H     H      Cl       H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              CH                          
CH   H     H      Cl       H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
CH   H     H      Cl       H    Cl     OCH.sub.3                          
                                              CH                          
CH   H     H      Cl       H    CH.sub.3                                  
                                       CH.sub.3                           
                                              CH                          
CH   H     H      Cl       H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              N                           
CH   H     H      Cl       H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
CH   H     H      Cl       H    OC.sub.2 H.sub.5                          
                                       NHCH.sub.3                         
                                              N                           
CH   H     H      Cl       CH.sub.3                                       
                                OCH.sub.3                                 
                                       CH     N                           
CH   H     H      SO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              CH                          
CH   H     H      SO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
CH   H     H      SO.sub.2 CH.sub.3                                       
                           H    Cl     OCH.sub.3                          
                                              CH                          
CH   H     H      SO.sub.2 CH.sub.3                                       
                           H    CH.sub.3                                  
                                       CH.sub.3                           
                                              CH                          
CH   H     H      SO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              N                           
CH   H     H      SO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
CH   H     H      SO.sub.2 CH.sub.3                                       
                           H    OC.sub.2 H.sub.5                          
                                       NHCH.sub.3                         
                                              N                           
CH   H     H      SO.sub.2 CH.sub.3                                       
                           CH.sub.3                                       
                                OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
N    H     H      H        H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              CH                          
N    H     H      H        H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
N    H     H      H        H    Cl     OCH.sub.3                          
                                              CH                          
N    H     H      H        H    CH.sub.3                                  
                                       CH.sub.3                           
                                              CH                          
N    H     H      H        H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              N                           
N    H     H      H        H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
N    H     H      H        H    OC.sub.2 H.sub.5                          
                                       NHCH.sub.3                         
                                              N                           
N    H     H      CH.sub.3 H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
N    H     H      Cl       H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              CH                          
N    H     H      Cl       H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
N    H     H      Cl       H    Cl     OCH.sub.3                          
                                              CH                          
N    H     H      Cl       H    CH.sub.3                                  
                                       CH.sub.3                           
                                              CH                          
N    H     H      Cl       H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              N                           
N    H     H      Cl       H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
N    H     H      Cl       H    OC.sub.2 H.sub.5                          
                                       NHCH.sub.3                         
                                              N                           
N    H     H      Cl       CH.sub.3                                       
                                OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
N    H     H      SO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              CH                          
N    H     H      SO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
N    H     H      SO.sub.2 CH.sub.3                                       
                           H    Cl     OCH.sub.3                          
                                              CH                          
N    H     H      SO.sub.2 CH.sub.3                                       
                           H    CH.sub.3                                  
                                       CH.sub.3                           
                                              CH                          
N    H     H      SO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              N                           
N    H     H      SO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
N    H     H      SO.sub.2 CH.sub.3                                       
                           H    OC.sub.2 H.sub.5                          
                                       NHCH.sub.3                         
                                              N                           
N    H     H      SO.sub.2 CH.sub.3                                       
                           CH.sub.3                                       
                                OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
CH   H     H      CO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              CH                          
CH   H     H      CO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
CH   H     H      CO.sub.2 CH.sub.3                                       
                           H    Cl     OCH.sub.3                          
                                              CH                          
CH   H     H      CO.sub.2 CH.sub.3                                       
                           H    CH.sub.3                                  
                                       CH.sub.3                           
                                              CH                          
CH   H     H      CO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              N                           
CH   H     H      CO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
CH   H     H      CO.sub.2 CH.sub.3                                       
                           H    OC.sub.2 H.sub.5                          
                                       NHCH.sub.3                         
                                              N                           
CH   H     H      CO.sub.2 CH.sub.3                                       
                           CH.sub.3                                       
                                OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              CH                          
CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           H    Cl     OCH.sub.3                          
                                              CH                          
CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           H    CH.sub.3                                  
                                       CH.sub.3                           
                                              CH                          
CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              N                           
CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           H    OC.sub.2 H.sub.5                          
                                       NHCH.sub.3                         
                                              N                           
CH   H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           CH.sub.3                                       
                                OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              CH                          
CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           H    Cl     OCH.sub.3                          
                                              CH                          
CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           H    CH.sub.3                                  
                                       CH.sub.3                           
                                              CH                          
CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              N                           
CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           H    OC.sub.2 H.sub.5                          
                                       NHCH.sub.3                         
                                              N                           
CH   H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           CH.sub.3                                       
                                OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
N    H     H      CO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              CH                          
N    H     H      CO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
N    H     H      CO.sub.2 CH.sub.3                                       
                           H    Cl     OCH.sub.3                          
                                              CH                          
N    H     H      CO.sub.2 CH.sub.3                                       
                           H    CH.sub.3                                  
                                       CH.sub.3                           
                                              CH                          
N    H     H      CO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              N                           
N    H     H      CO.sub.2 CH.sub.3                                       
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
N    H     H      CO.sub.2 CH.sub.3                                       
                           H    OC.sub.2 H.sub.5                          
                                       NHCH.sub.3                         
                                              N                           
N    H     H      CO.sub.2 CH.sub.3                                       
                           CH.sub.3                                       
                                OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
N    H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              CH                          
N    H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
N    H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           H    Cl     OCH.sub.3                          
                                              CH                          
N    H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           H    CH.sub.3                                  
                                       CH.sub.3                           
                                              CH                          
N    H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              N                           
N    H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
N    H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           H    OC.sub.2 H.sub.5                          
                                       NHCH.sub.3                         
                                              N                           
N    H     H      CO.sub.2 C.sub.2 H.sub.5                                
                           CH.sub.3                                       
                                OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
N    H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           H    OCH.sub. 3                                
                                       OCH.sub.3                          
                                              CH                          
N    H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              CH                          
N    H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           H    Cl     OCH.sub.3                          
                                              CH                          
N    H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           H    CH.sub.3                                  
                                       CH.sub.3                           
                                              CH                          
N    H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           H    OCH.sub.3                                 
                                       OCH.sub.3                          
                                              N                           
N    H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           H    OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
N    H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           H    OC.sub.2 H.sub.5                          
                                       NHCH.sub.3                         
                                              N                           
N    H     H      SO.sub.2 N(CH.sub.3).sub.2                              
                           CH.sub.3                                       
                                OCH.sub.3                                 
                                       CH.sub.3                           
                                              N                           
______________________________________                                    
 
    
     
                       TABLE 11                                                    
______________________________________                                    
General Formula 11                                                        
                                            M.P.                          
R.sup.3                                                                   
    R.sup.5     R       X      Y       Z.sup.4                            
                                            (°C.)                  
______________________________________                                    
H   H           H       OCH.sub.3                                         
                               OCH.sub.3                                  
                                       CH                                 
H   H           H       OCH.sub.3                                         
                               CH.sub.3                                   
                                       CH                                 
H   H           H       Cl     OCH.sub.3                                  
                                       CH                                 
H   H           H       CH.sub.3                                          
                               CH.sub.3                                   
                                       CH                                 
H   H           H       OCH.sub.3                                         
                               OCH.sub.3                                  
                                       N                                  
H   H           H       OCH.sub.3                                         
                               CH.sub.3                                   
                                       N                                  
H   H           H       OC.sub.2 H.sub.5                                  
                               NHCH.sub.3                                 
                                       N                                  
H   H           CH.sub.3                                                  
                        OCH.sub.3                                         
                               CH.sub.3                                   
                                       N                                  
H   Cl          H       OCH.sub.3                                         
                               OCH.sub.3                                  
                                       CH                                 
H   Cl          H       OCH.sub.3                                         
                               CH.sub.3                                   
                                       CH                                 
H   Cl          H       Cl     OCH.sub.3                                  
                                       CH                                 
H   Cl          H       CH.sub.3                                          
                               CH.sub.3                                   
                                       CH                                 
H   Cl          H       OCH.sub.3                                         
                               OCH.sub.3                                  
                                       N                                  
H   Cl          H       OCH.sub.3                                         
                               CH.sub.3                                   
                                       N                                  
H   Cl          H       OC.sub.2 H.sub.5                                  
                               NHCH.sub.3                                 
                                       N                                  
H   Cl          CH.sub.3                                                  
                        OCH.sub.3                                         
                               CH.sub.3                                   
                                       N                                  
H   SO.sub.2 CH.sub.3                                                     
                H       OCH.sub.3                                         
                               OCH.sub.3                                  
                                       CH                                 
H   SO.sub.2 CH.sub.3                                                     
                H       OCH.sub.3                                         
                               CH.sub.3                                   
                                       CH                                 
H   SO.sub.2 CH.sub. 3                                                    
                H       Cl     OCH.sub.3                                  
                                       CH                                 
H   SO.sub.2 CH.sub.3                                                     
                H       CH.sub.3                                          
                               CH.sub.3                                   
                                       CH                                 
H   SO.sub.2 CH.sub.3                                                     
                H       OCH.sub.3                                         
                               OCH.sub.3                                  
                                       N                                  
H   SO.sub.2 CH.sub.3                                                     
                H       OCH.sub.3                                         
                               CH.sub.3                                   
                                       N                                  
H   SO.sub.2 CH.sub.3                                                     
                H       OC.sub.2 H.sub.5                                  
                               NHCH.sub.3                                 
                                       N                                  
H   SO.sub.2 CH.sub.3                                                     
                CH.sub.3                                                  
                        OCH.sub.3                                         
                               CH.sub.3                                   
                                       N                                  
H   CO.sub.2 CH.sub.3                                                     
                H       OCH.sub.3                                         
                               OCH.sub.3                                  
                                       CH                                 
H   CO.sub.2 CH.sub.3                                                     
                H       OCH.sub.3                                         
                               CH.sub.3                                   
                                       CH                                 
H   CO.sub.2 CH.sub.3                                                     
                H       Cl     OCH.sub.3                                  
                                       CH                                 
H   CO.sub.2 CH.sub.3                                                     
                H       CH.sub.3                                          
                               CH.sub.3                                   
                                       CH                                 
H   CO.sub.2 CH.sub.3                                                     
                H       OCH.sub.3                                         
                               OCH.sub.3                                  
                                       N                                  
H   CO.sub.2 CH.sub.3                                                     
                H       OCH.sub.3                                         
                               CH.sub.3                                   
                                       N                                  
H   CO.sub.2 CH.sub.3                                                     
                H       OC.sub.2 H.sub.5                                  
                               NHCH.sub.3                                 
                                       N                                  
H   CO.sub.2 CH.sub.3                                                     
                CH.sub.3                                                  
                        OCH.sub.3                                         
                               CH.sub.3                                   
                                       N                                  
H   CO.sub.2 C.sub.2 H.sub.5                                              
                H       OCH.sub.3                                         
                               OCH.sub.3                                  
                                       CH                                 
H   CO.sub.2 C.sub.2 H.sub.5                                              
                H       OCH.sub.3                                         
                               CH.sub.3                                   
                                       CH                                 
H   CO.sub.2 C.sub.2 H.sub.5                                              
                H       Cl     OCH.sub.3                                  
                                       CH                                 
H   CO.sub.2 C.sub.2 H.sub.5                                              
                H       CH.sub.3                                          
                               CH.sub.3                                   
                                       CH                                 
H   CO.sub.2 C.sub.2 H.sub.5                                              
                H       OCH.sub.3                                         
                               OCH.sub.3                                  
                                       N                                  
H   CO.sub.2 C.sub.2 H.sub.5                                              
                H       OCH.sub.3                                         
                               CH.sub.3                                   
                                       N                                  
H   CO.sub.2 C.sub.2 H.sub.5                                              
                H       OC.sub.2 H.sub.5                                  
                               NHCH.sub.3                                 
                                       N                                  
H   CO.sub.2 C.sub.2 H.sub.5                                              
                CH.sub.3                                                  
                        OCH.sub.3                                         
                               CH.sub.3                                   
                                       N                                  
H   SO.sub.2 N(CH.sub.3).sub.2                                            
                H       OCH.sub.3                                         
                               OCH.sub.3                                  
                                       CH                                 
H   SO.sub.2 N(CH.sub.3).sub.2                                            
                H       OCH.sub.3                                         
                               CH.sub.3                                   
                                       CH                                 
H   SO.sub.2 N(CH.sub.3).sub.2                                            
                H       Cl     OCH.sub.3                                  
                                       CH                                 
H   SO.sub.2 N(CH.sub.3).sub.2                                            
                H       CH.sub.3                                          
                               CH.sub.3                                   
                                       CH                                 
H   SO.sub.2 N(CH.sub.3).sub.2                                            
                H       OCH.sub.3                                         
                               OCH.sub.3                                  
                                       N                                  
H   SO.sub.2 N(CH.sub.3).sub.2                                            
                H       OCH.sub.3                                         
                               CH.sub.3                                   
                                       N                                  
H   SO.sub.2 N(CH.sub.3).sub.2                                            
                H       OC.sub.2 H.sub.5                                  
                               NHCH.sub.3                                 
                                       N                                  
H   SO.sub.2 N(CH.sub.3).sub.2                                            
                CH.sub.3                                                  
                        OCH.sub.3                                         
                               CH.sub.3                                   
                                       N                                  
______________________________________                                    
 
    
     
                       TABLE 12                                                    
______________________________________                                    
R.sup.1  R.sup.2                                                          
                R.sup.4                                                   
                       R     X      Y       Z.sup.4                       
______________________________________                                    
H        H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
H        H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
H        H      H      H     Cl     OCH.sub.3                             
                                            CH                            
H        H      H      H     CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
H        H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
H        H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
H        H      H      H     OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
H        H      H      CH.sub.3                                           
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
Cl       H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
Cl       H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
Cl       H      H      H     Cl     OCH.sub.3                             
                                            CH                            
Cl       H      H      H     CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
Cl       H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
Cl       H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
Cl       H      H      H     OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
Cl       H      H      CH.sub.3                                           
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
SO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
SO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
SO.sub.2 CH.sub.3                                                         
         H      H      H     Cl     OCH.sub.3                             
                                            CH                            
SO.sub.2 CH.sub.3                                                         
         H      H      H     CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
SO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
SO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
SO.sub.2 CH.sub.3                                                         
         H      H      H     OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
SO.sub.2 CH.sub.3                                                         
         H      H      CH.sub.3                                           
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
CO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
CO.sub.2 CH.sub.3                                                         
         H      H      H     Cl     OCH.sub.3                             
                                            CH                            
CO.sub.2 CH.sub.3                                                         
         H      H      H     CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
CO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
CO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CO.sub.2 CH.sub.3                                                         
         H      H      H     OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
CO.sub.2 CH.sub.3                                                         
         H      H      CH.sub.3                                           
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      H     Cl     OCH.sub.3                             
                                            CH                            
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      H     CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      H     OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      CH.sub.3                                           
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      H     Cl     OCH.sub.3                             
                                            CH                            
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      H     CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      H     OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      CH.sub.3                                           
                             OCH.sub. 3                                   
                                    CH.sub.3                              
                                            N                             
______________________________________                                    
 
    
     
                       TABLE 13                                                    
______________________________________                                    
General Formula 13                                                        
R.sup.2  R.sup.4                                                          
                R        X      Y       Z.sup.4                           
______________________________________                                    
H        H      H        OCH.sub.3                                        
                                OCH.sub.3                                 
                                        CH                                
H        H      H        OCH.sub.3                                        
                                CH.sub.3                                  
                                        CH                                
H        H      H        Cl     OCH.sub.3                                 
                                        CH                                
H        H      H        CH.sub.3                                         
                                CH.sub.3                                  
                                        CH                                
H        H      H        OCH.sub.3                                        
                                OCH.sub.3                                 
                                        N                                 
H        H      H        OCH.sub.3                                        
                                CH.sub.3                                  
                                        N                                 
H        H      H        OC.sub.2 H.sub.5                                 
                                NHCH.sub.3                                
                                        N                                 
H        H      CH.sub.3 OCH.sub.3                                        
                                CH.sub.3                                  
                                        N                                 
CH.sub.3 H      H        OCH.sub.3                                        
                                OCH.sub.3                                 
                                        CH                                
CH.sub.3 H      H        OCH.sub.3                                        
                                CH.sub.3                                  
                                        CH                                
CH.sub.3 H      H        Cl     OCH.sub.3                                 
                                        CH                                
CH.sub.3 H      H        CH.sub.3                                         
                                CH.sub.3                                  
                                        CH                                
CH.sub.3 H      H        OCH.sub.3                                        
                                OCH.sub.3                                 
                                        N                                 
CH.sub.3 H      H        OCH.sub.3                                        
                                CH.sub.3                                  
                                        N                                 
CH.sub.3 H      H        OC.sub.2 H.sub.5                                 
                                NHCH.sub.3                                
                                        N                                 
CH.sub.3 H      CH.sub.3 OCH.sub.3                                        
                                CH.sub.3                                  
                                        N                                 
OCH.sub.3                                                                 
         H      H        OCH.sub.3                                        
                                OCH.sub.3                                 
                                        CH                                
OCH.sub.3                                                                 
         H      H        OCH.sub.3                                        
                                CH.sub.3                                  
                                        CH                                
OCH.sub.3                                                                 
         H      H        Cl     OCH.sub.3                                 
                                        CH                                
OCH.sub.3                                                                 
         H      H        CH.sub.3                                         
                                CH.sub.3                                  
                                        CH                                
OCH.sub.3                                                                 
         H      H        OCH.sub.3                                        
                                OCH.sub.3                                 
                                        N                                 
OCH.sub.3                                                                 
         H      H        OCH.sub.3                                        
                                CH.sub.3                                  
                                        N                                 
OCH.sub.3                                                                 
         H      H        OC.sub.2 H.sub.5                                 
                                NHCH.sub.3                                
                                        N                                 
OCH.sub.3                                                                 
         H      CH       OCH.sub.3                                        
                                CH.sub.3                                  
                                        N                                 
______________________________________                                    
 
    
     
                       TABLE 14                                                    
______________________________________                                    
General Formula 14                                                        
R.sup.1  R.sup.2                                                          
                R.sup.4                                                   
                       R     X      Y       Z.sup.4                       
______________________________________                                    
H        H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
H        H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
H        H      H      H     Cl     OCH.sub.3                             
                                            CH                            
H        H      H      H     CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
H        H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
H        H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
H        H      H      H     OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
H        H      H      CH.sub.3                                           
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
Cl       H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
Cl       H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
Cl       H      H      H     Cl     OCH.sub.3                             
                                            CH                            
Cl       H      H      H     CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
Cl       H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
Cl       H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
Cl       H      H      H     OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
Cl       H      H      CH.sub.3                                           
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
SO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
SO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
SO.sub.2 CH.sub.3                                                         
         H      H      H     Cl     OCH.sub.3                             
                                            CH                            
SO.sub.2 CH.sub.3                                                         
         H      H      H     CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
SO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
SO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
SO.sub.2 CH.sub.3                                                         
         H      H      H     OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
SO.sub.2 CH.sub.3                                                         
         H      H      CH.sub.3                                           
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
CO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
CO.sub.2 CH.sub.3                                                         
         H      H      H     Cl     OCH.sub.3                             
                                            CH                            
CO.sub.2 CH.sub.3                                                         
         H      H      H     CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
CO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
CO.sub.2 CH.sub.3                                                         
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CO.sub.2 CH.sub.3                                                         
         H      H      H     OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
CO.sub.2 CH.sub.3                                                         
         H      H      CH.sub.3                                           
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      H     Cl     OCH.sub.3                             
                                            CH                            
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      H     CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      H     OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
CO.sub.2 C.sub.2 H.sub.5                                                  
         H      H      CH.sub.3                                           
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      H     Cl     OCH.sub.3                             
                                            CH                            
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      H     CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      H     OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      H     OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      H     OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
SO.sub.2 N(CH.sub.3).sub.2                                                
         H      H      CH.sub.3                                           
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
______________________________________                                    
 
    
     
                       TABLE 15                                                    
______________________________________                                    
General Formula 15                                                        
Z.sup.1                                                                   
     R.sup.1     R.sup.2                                                  
                        R    X      Y       Z.sup.4                       
______________________________________                                    
CH   H           H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
CH   H           H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
CH   H           H      H    Cl     OCH.sub.3                             
                                            CH                            
CH   H           H      H    CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
CH   H           H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
CH   H           H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CH   H           H      H    OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
CH   H           H      CH.sub.3                                          
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CH   Cl          H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
CH   Cl          H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
CH   Cl          H      H    Cl     OCH.sub.3                             
                                            CH                            
CH   Cl          H      H    CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
CH   Cl          H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
CH   Cl          H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CH   Cl          H      H    OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
CH   Cl          H      CH.sub.3                                          
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CH   SO.sub. 2 CH.sub.3                                                   
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
CH   SO.sub.2 CH.sub.3                                                    
                 H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
CH   SO.sub.2 CH.sub.3                                                    
                 H      H    Cl     OCH.sub.3                             
                                            CH                            
CH   SO.sub.2 CH.sub.3                                                    
                 H      H    CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
CH   SO.sub.2 CH.sub.3                                                    
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
CH   SO.sub.2 CH.sub.3                                                    
                 H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CH   SO.sub.2 CH.sub.3                                                    
                 H      H    OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
CH   SO.sub.2 CH.sub.3                                                    
                 H      CH.sub.3                                          
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CH   CO.sub.2 CH.sub.3                                                    
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
CH   CO.sub.2 CH.sub.3                                                    
                 H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
CH   CO.sub.2 CH.sub.3                                                    
                 H      H    Cl     OCH.sub.3                             
                                            CH                            
CH   CO.sub.2 CH.sub.3                                                    
                 H      H    CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
CH   CO.sub.2 CH.sub.3                                                    
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
CH   CO.sub.2 CH.sub.3                                                    
                 H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CH   CO.sub.2 CH.sub.3                                                    
                 H      H    OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
CH   CO.sub.2 CH.sub.3                                                    
                 H      CH.sub.3                                          
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CH   CO.sub.2 C.sub.2 H.sub.5                                             
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
CH   CO.sub.2 C.sub.2 H.sub.5                                             
                 H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
CH   CO.sub.2 C.sub.2 H.sub.5                                             
                 H      H    Cl     OCH.sub.3                             
                                            CH                            
CH   CO.sub.2 C.sub.2 H.sub.5                                             
                 H      H    CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
CH   CO.sub.2 C.sub.2 H.sub.5                                             
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
CH   CO.sub.2 C.sub.2 H.sub.5                                             
                 H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CH   CO.sub.2 C.sub.2 H.sub.5                                             
                 H      H    OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
CH   CO.sub.2 C.sub.2 H.sub.5                                             
                 H      CH.sub.3                                          
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CH   SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
CH   SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
CH   SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      H    Cl     OCH.sub.3                             
                                            CH                            
CH   SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      H    CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
CH   SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
CH   SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
CH   SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      H    OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
CH   SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      CH.sub.3                                          
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
N    H           H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
N    H           H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
N    H           H      H    Cl     OCH.sub.3                             
                                            CH                            
N    H           H      H    CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
N    H           H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
N    H           H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
N    H           H      H    OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
N    H           H      CH.sub.3                                          
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
N    Cl          H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
N    Cl          H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
N    Cl          H      H    Cl     OCH.sub.3                             
                                            CH                            
N    Cl          H      H    CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
N    Cl          H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
N    Cl          H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
N    Cl          H      H    OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
N    Cl          H      CH.sub.3                                          
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
N    SO.sub.2 CH.sub.3                                                    
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
N    SO.sub.2 CH.sub.3                                                    
                 H      H    OCH.sub.3                                    
                                    CH.sub. 3                             
                                            CH                            
N    SO.sub.2 CH.sub.3                                                    
                 H      H    Cl     OCH.sub.3                             
                                            CH                            
N    SO.sub.2 CH.sub.3                                                    
                 H      H    CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
N    SO.sub.2 CH.sub.3                                                    
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
N    SO.sub.2 CH.sub.3                                                    
                 H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
N    SO.sub.2 CH.sub.3                                                    
                 H      H    OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
N    SO.sub.2 CH.sub.3                                                    
                 H      CH.sub.3                                          
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
N    CO.sub.2 CH.sub.3                                                    
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
N    CO.sub.2 CH.sub.3                                                    
                 H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
N    CO.sub.2 CH.sub.3                                                    
                 H      H    Cl     OCH.sub.3                             
                                            CH                            
N    CO.sub.2 CH.sub.3                                                    
                 H      H    CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
N    CO.sub.2 CH.sub.3                                                    
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
N    CO.sub.2 CH.sub.3                                                    
                 H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
N    CO.sub.2 CH.sub.3                                                    
                 H      H    OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
N    CO.sub.2 CH.sub.3                                                    
                 H      CH.sub.3                                          
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
N    CO.sub.2 C.sub.2 H.sub.5                                             
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
N    CO.sub.2 C.sub.2 H.sub.5                                             
                 H      H    OCH.sub.3                                    
                                    CH.sub. 3                             
                                            CH                            
N    CO.sub.2 C.sub.2 H.sub.5                                             
                 H      H    Cl     OCH.sub.3                             
                                            CH                            
N    CO.sub.2 C.sub.2 H.sub.5                                             
                 H      H    CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
N    CO.sub.2 C.sub.2 H.sub.5                                             
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
N    CO.sub.2 C.sub.2 H.sub.5                                             
                 H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
N    CO.sub.2 C.sub.2 H.sub.5                                             
                 H      H    OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
N    CO.sub.2 C.sub.2 H.sub.5                                             
                 H      CH.sub.3                                          
                             OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
N    SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            CH                            
N    SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            CH                            
N    SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      H    Cl     OCH.sub.3                             
                                            CH                            
N    SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      H    CH.sub.3                                     
                                    CH.sub.3                              
                                            CH                            
N    SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      H    OCH.sub.3                                    
                                    OCH.sub.3                             
                                            N                             
N    SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      H    OCH.sub.3                                    
                                    CH.sub.3                              
                                            N                             
N    SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      H    OC.sub.2 H.sub.5                             
                                    NHCH.sub.3                            
                                            N                             
N    SO.sub.2 N(CH.sub.3).sub.2                                           
                 H      CH.sub.3                                          
                             OCH.sub.3                                    
                                    CH.sub. 3                             
                                            N                             
______________________________________                                    
 
    
     
                       TABLE 16                                                    
______________________________________                                    
General Formula 16                                                        
Z.sup.1                                                                   
      R.sup.2  R.sup.4                                                    
                      R     X      Y       Z.sup.4                        
______________________________________                                    
CH    H        H      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           CH                             
CH    H        H      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           CH                             
CH    H        H      H     Cl     OCH.sub.3                              
                                           CH                             
CH    H        H      H     CH.sub.3                                      
                                   CH.sub.3                               
                                           CH                             
CH    H        H      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           N                              
CH    H        H      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
CH    H        H      H     OC.sub.2 H.sub.5                              
                                   NHCH.sub.3                             
                                           N                              
CH    H        H      CH.sub.3                                            
                            OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
CH    CH.sub.3 H      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           CH                             
CH    CH.sub.3 H      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           CH                             
CH    CH.sub.3 H      H     Cl     OCH.sub.3                              
                                           CH                             
CH    CH.sub.3 H      H     CH.sub.3                                      
                                   CH.sub.3                               
                                           CH                             
CH    CH.sub.3 H      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           N                              
CH    CH.sub.3 H      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
CH    CH.sub.3 H      H     OC.sub.2 H.sub.5                              
                                   NHCH.sub.3                             
                                           N                              
CH    CH.sub.3 H      CH.sub.3                                            
                            OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
CH    OCH.sub.3                                                           
               H      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           CH                             
CH    OCH.sub.3                                                           
               H      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           CH                             
CH    OCH.sub.3                                                           
               H      H     Cl     OCH.sub.3                              
                                           CH                             
CH    OCH.sub.3                                                           
               H      H     CH.sub.3                                      
                                   CH.sub.3                               
                                           CH                             
CH    OCH.sub.3                                                           
               H      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           N                              
CH    OCH      H      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
CH    OCH.sub.3                                                           
               H      H     OC.sub.2 H.sub.5                              
                                   NHCH.sub.3                             
                                           N                              
CH    OCH.sub.3                                                           
               H      CH.sub.3                                            
                            OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
N     H        H      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           CH                             
N     H        H      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           CH                             
N     H        H      H     Cl     OCH.sub.3                              
                                           CH                             
N     H        H      H     CH.sub.3                                      
                                   CH.sub.3                               
                                           CH                             
N     H        H      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           N                              
N     H        H      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
N     H        H      H     OC.sub.2 H.sub.5                              
                                   NHCH.sub.3                             
                                           N                              
N     H        H      CH.sub.3                                            
                            OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
N     CH.sub.3 H      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           CH                             
N     CH.sub.3 H      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           CH                             
N     CH.sub.3 H      H     Cl     OCH.sub.3                              
                                           CH                             
N     CH.sub.3 H      H     CH.sub.3                                      
                                   CH.sub.3                               
                                           CH                             
N     CH.sub.3 H      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           N                              
N     CH.sub.3 H      H     OCH.sub. 3                                    
                                   CH.sub.3                               
                                           N                              
N     CH.sub.3 H      H     OC.sub.2 H.sub.5                              
                                   NHCH.sub.3                             
                                           N                              
N     CH.sub.3 H      CH.sub.3                                            
                            OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
N     OCH.sub.3                                                           
               H      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           CH                             
N     OCH.sub.3                                                           
               H      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           CH                             
N     OCH.sub.3                                                           
               H      H     Cl     OCH.sub.3                              
                                           CH                             
N     OCH.sub.3                                                           
               H      H     CH.sub.3                                      
                                   CH.sub.3                               
                                           CH                             
N     OCH.sub.3                                                           
               H      H     OCH.sub.3                                     
                                   OCH.sub.3                              
                                           N                              
N     OCH.sub.3                                                           
               H      H     OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
N     OCH.sub.3                                                           
               H      H     OC.sub.2 H.sub.5                              
                                   NHCH.sub.3                             
                                           N                              
N     OCH.sub.3                                                           
               H      CH.sub.3                                            
                            OCH.sub.3                                     
                                   CH.sub.3                               
                                           N                              
______________________________________                                    
 
    
     
                       TABLE 17                                                    
______________________________________                                    
General Formula 17                                                        
Z     Z.sup.2 R.sup.2                                                     
                     R.sup.3                                              
                          R    X      Y      Z.sup.4                      
______________________________________                                    
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    O       CH.sub.3                                                    
                     H    H    Cl     OCH.sub.3                           
                                             CH                           
CH    O       CH.sub.3                                                    
                     H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    O       CH.sub.3                                                    
                     H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    O       CH.sub.3                                                    
                     H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     O       CH.sub.3                                                    
                     H    H    Cl     OCH.sub.3                           
                                             CH                           
N     O       CH.sub.3                                                    
                     H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       CH.sub.3                                                    
                     H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     O       CH.sub.3                                                    
                     H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    S       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    S       CH.sub.3                                                    
                     H    H    Cl     OCH.sub.3                           
                                             CH                           
CH    S       CH.sub.3                                                    
                     H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    S       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    S       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       CH.sub.3                                                    
                     H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    S       CH.sub.3                                                    
                     H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    O       H      CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
CH    O       H      CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    O       H      CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    O       H      CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     O       H      CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
N     O       H      CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       H      CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     O       H      CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    S       H      CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
CH    S       H      CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       H      CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    S       H      CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    O       H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    O       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    O       H      H    H    Cl     OCH.sub.3                           
                                             CH                           
CH    O       H      H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    O       H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    O       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    O       H      H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    O       H      H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     O       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     O       H      H    H    Cl     OCH.sub.3                           
                                             CH                           
N     O       H      H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     O       H      H    H    OCH.sub.3                                  
                                      OCH.sub. 3                          
                                             N                            
N     O       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       H      H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     O       H      H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    S       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    S       H      H    H    Cl     OCH.sub.3                           
                                             CH                           
CH    S       H      H    H    CH     CH.sub.3                            
                                             CH                           
CH    S       H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    S       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       H      H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    S       H      H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     S       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     S       CH.sub.3                                                    
                     H    H    Cl     OCH.sub.3                           
                                             CH                           
N     S       CH.sub.3                                                    
                     H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     S       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     S       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       CH.sub.3                                                    
                     H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     S       CH.sub.3                                                    
                     H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    Cl     OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    Cl     OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     S       H      CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
N     S       H      CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       H      CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     S       H      CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     S       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     S       H      H    H    Cl     OCH.sub.3                           
                                             CH                           
N     S       H      H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     S       H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     S       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       H      H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     S       H      H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              H      H    H    Cl     OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              H      H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              H      H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    NCH.sub.3                                                           
              H      H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              H      H    H    Cl     OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              H      H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              H      H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     NCH.sub.3                                                           
              H      H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
______________________________________                                    
 
    
     
                       TABLE 18                                                    
______________________________________                                    
General Formula 18                                                        
Z     Z.sup.3 R.sup.2                                                     
                     R.sup.3                                              
                          R    X      Y      Z.sup.4                      
______________________________________                                    
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    O       CH.sub.3                                                    
                     CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     O       CH.sub.3                                                    
                     CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    S       CH.sub.3                                                    
                     CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    O       CH.sub.3                                                    
                     H    H    Cl     OCH.sub.3                           
                                             CH                           
CH    O       CH.sub.3                                                    
                     H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    O       CH.sub.3                                                    
                     H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    O       CH.sub.3                                                    
                     H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     O       CH.sub.3                                                    
                     H    H    Cl     OCH.sub.3                           
                                             CH                           
N     O       CH.sub.3                                                    
                     H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     O       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       CH.sub.3                                                    
                     H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     O       CH.sub.3                                                    
                     H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    S       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    S       CH.sub.3                                                    
                     H    H    Cl     OCH.sub.3                           
                                             CH                           
CH    S       CH.sub.3                                                    
                     H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    S       CH.sub.3                                                    
                     H    H    OCH.sub. 3                                 
                                      OCH.sub.3                           
                                             N                            
CH    S       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       CH.sub.3                                                    
                     H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    S       CH.sub.3                                                    
                     H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    O       H      CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
CH    O       H      CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    O       H      CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    O       H      CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     O       H      CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
N     O       H      CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     O       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       H      CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     O       H      CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    S       H      CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
CH    S       H      CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       H      CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    S       H      CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    O       H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    O       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    O       H      H    H    Cl     OCH.sub.3                           
                                             CH                           
CH    O       H      H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    O       H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    O       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    O       H      H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    O       H      H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     O       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     O       H      H    H    Cl     OCH.sub.3                           
                                             CH                           
N     O       H      H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     O       H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     O       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     O       H      H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     O       H      H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    S       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    S       H      H    H    Cl     OCH.sub.3                           
                                             CH                           
CH    S       H      H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    S       H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    S       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    S       H      H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    S       H      H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     S       CH.sub.3                                                    
                     CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub. 3                                 
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     S       H      CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
N     S       H      CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     S       H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       H      CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     S       H      CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    NCH.sub.3                                                           
              H      CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    Cl     OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     NCH.sub.3                                                           
              H      CH.sub.3                                             
                          CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     S       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     S       H      H    H    Cl     OCH.sub.3                           
                                             CH                           
N     S       H      H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     S       H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     S       H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       H      H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     S       H      H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              H      H    H    Cl     OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              H      H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              H      H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    NCH.sub.3                                                           
              H      H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              H      H    H    Cl     OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              H      H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     NCH.sub.3                                                           
              H      H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              H      H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     NCH.sub.3                                                           
              H      H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     S       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     S       CH.sub.3                                                    
                     H    H    Cl     OCH.sub.3                           
                                             CH                           
N     S       CH.sub.3                                                    
                     H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     S       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     S       CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     S       CH.sub.3                                                    
                     H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     S       CH.sub.3                                                    
                     H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    Cl     OCH.sub.3                           
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
CH    NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    Cl     OCH.sub.3                           
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    CH.sub.3                                   
                                      CH.sub.3                            
                                             CH                           
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      OCH.sub.3                           
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    H    OC.sub.2 H.sub.5                           
                                      NHCH.sub.3                          
                                             N                            
N     NCH.sub.3                                                           
              CH.sub.3                                                    
                     H    CH.sub.3                                        
                               OCH.sub.3                                  
                                      CH.sub.3                            
                                             N                            
______________________________________                                    
 
    
     Formulations 
     Useful formulations of the compounds of Formula I can be prepared in conventional ways. They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few liters to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain about 0.1% to 99% by weight of active ingredient(s) and at least one of (a) about 0.1% to 20% surfactant(s). More specifically, they will contain these ingredients in the following approximate proportions: 
     
         ______________________________________                                    
            Weight Percent*                                               
            Active                                                        
            Ingredients                                                   
                    Diluent (s)                                           
                              Surfactant (s)                              
______________________________________                                    
Wettable powders                                                          
              20-90      0-74     1-10                                    
Oil Suspensions,                                                          
               3-50     40-95     0-15                                    
Emulsions, Solutions,                                                     
(including Emulsifiable                                                   
Concentrates)                                                             
Aqueous Suspension                                                        
              10-50     40-84     1-20                                    
Dusts          1-25     70-99     0-5                                     
Granules and Pellets                                                      
              0.1-95      5-99.9  0-15                                    
High Strength 90-99      0-10     0-2                                     
Compositions                                                              
______________________________________                                    
 *Active ingredient plus at least one of a Surfactant of a Diluent equals 
 100 weight percent.                                                      
 
    
     Lower or higher levels of active ingredient can, of course, be present depending on the intended use of the physical properties of the compound. Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing. 
     Typical solid diluents are described in Watkins, et al., &#34;Handbook of Insecticide Dust Diluents and Carriers&#34;, 2nd Ed., Dorland Books, Caldwell, N.J., but other solids, either mined or manufactered, may be used. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, &#34;Solvents Guide,&#34; 2nd Ed., Interscience, New York, 1985. Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0° C. &#34;McCutcheon&#39;s Detergents and Emulsifiers Annual&#34;, MC Publishing Corp., Ridgewood, N.J., as well as Sisely and Wood, &#34;Encyclopedia of Surface Active Agents&#34;, Chemical Publishing Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foaming, caking, corrosion, microbiological growth, etc. 
     The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made by spraying the active material upon preformed granular carriers or by agglomeration techniques. See J. E. Browning, &#34;Agglomeration&#34;, Chemical Engineering, Dec. 4, 1967, pp. 147ff. and &#34;Perry&#39;s Chemical Engineer&#39;s Handbook&#34;, 5th ed., McGraw-Hill, New York, 1973, pp. 8-57ff. 
     For further information regarding the art of formulation, see for example: 
     H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, Col. 6, line 16 through Col. 7, line 19 and Examples 10 through 41; 
     R. W. Luchenbaugh, U.S. Pat. No. 3,309,192, Mar. 14, 1967, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182; 
     H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, June 23, 1959, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4; 
     G. C. Klingman, &#34;Weed Control as a Science&#34;, John Wiley and Sons, Inc., New York, 1961, pp. 81-96; and 
     J. D. Fryer and S. A. Evans, &#34;Weed Control Handbook&#34;, 5th ed., Blackwell Scientific Publications, Oxford, 1968, pp. 101-103. 
     In the following examples, all parts are by weight unless otherwise indicated. 
     EXAMPLE 1 
     Wettable Powder 
     
         ______________________________________                                    
N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                         
                          80%                                             
2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                            
sulfonamide                                                               
sodium alkylnaphthalenesulfonate                                          
                          2%                                              
sodium ligninsulfonate    2%                                              
synthetic amorphous silica                                                
                          3%                                              
kaolinite                 13%                                             
______________________________________                                    
 
    
     The ingredients are blended, hammer-milled until all the solids are essentially under 50 microns, reblended, and packaged. 
     EXAMPLE 2 
     Wettable Powder 
     
         ______________________________________                                    
N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                    
                             50%                                          
isoxazolo[4,5-b] pyridine-3-sulfonamide                                   
sodium alkylnaphthalenesulfonate                                          
                              2%                                          
low viscosity methyl cellulose                                            
                              2%                                          
diatomaceous earth           46%                                          
______________________________________                                    
 
    
     The ingredients are blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in diameter. The product is reblended before packaging. 
     EXAMPLE 3 
     Granule 
     
         ______________________________________                                    
Wettable Powder of Example 2                                              
                        5%                                                
attapulgite granules   95%                                                
(U.S.S. 20-40 mesh; 0.84-0.42 mm)                                         
______________________________________                                    
 
    
     A slurry of wettable powder containing 25% solids is sprayed on the surfact of attapulgite granules in a double-cone blender. The granules are dried and packaged. 
     EXAMPLE 4 
     Extruded Pellet 
     
         ______________________________________                                    
N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                         
                            25%                                           
2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                            
sulfonamide                                                               
anhydrous sodium sulfate    10%                                           
crude calcium ligninsulfonate                                             
                             5%                                           
sodium alkylnaphthalenesulfonate                                          
                             1%                                           
calcium/magnesium bentonite 59%                                           
______________________________________                                    
 
    
     The ingredients are blended, hammer-milled and then moistened with about 12% water. The mixture is extruded as cylinders about 3 mm diameter which are cut to produce pellets about 3 mm long. These may be used directly after drying, or the dried pellets may be crushed to pass a U.S. Ser. No. 20 sieve (0.84 MM openings). The granules held on a U.S. Ser. No. 40 sieve (0.42 mm openings) may be packaged for use and the fines recycled. 
     EXAMPLE 5 
     Oil Suspension 
     
         ______________________________________                                    
N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                    
                             25%                                          
isoxazolo[4,5-b] pyridine-3-sulfonamide                                   
polyoxyethylene sorbitol hexaoleate                                       
                              5%                                          
highly aliphatic hydrocarbon oil                                          
                             70%                                          
______________________________________                                    
 
    
     The ingredients are ground together in a sand mill until the solid particles have been reduced to under about 5 microns. The resulting thick suspension may be applied directly, but preferably after being extended with oils or emulsified in water. 
     EXAMPLE 6 
     Wettable Powder 
     
         ______________________________________                                    
N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                         
                          20%                                             
2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                            
sulfonamide                                                               
sodium alkylnaphthalenesulfonate                                          
                          4%                                              
sodium ligninsulfonate    4%                                              
low viscosity methyl cellulose                                            
                          3%                                              
attapulgite               69%                                             
______________________________________                                    
 
    
     The ingredients are thoroughly blended. After grinding in a hammer-mill to produce particles essentially all below 100 microns, the material is reblended and sifted through a U.S. Ser. No. 50 sieve (0.3 mm opening) and packaged. 
     EXAMPLE 7 
     Low Strength Granule 
     
         ______________________________________                                    
N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                    
                             1%                                           
isoxazolo[4,5-b] pyridine-3-sulfonamide                                   
N,N-dimethylformamide        9%                                           
attapulgite granules         90%                                          
(U.S.S. 20-2-40 sieve)                                                    
______________________________________                                    
 
    
     The active ingredient is dissolved in the solvent and the solution is sprayed upon dedusted granules in a double cone blender. After spraying of the solution has been completed, the blender is allowed to run for a short period and then the granules are packaged. 
     EXAMPLE 8 
     Aqueous Suspension 
     
         ______________________________________                                    
N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                         
                            40%                                           
2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                            
sulfonamide                                                               
polyacrylic acid thickener  0.3%                                          
dodecylphenol polyethylene glycol ether                                   
                            0.5%                                          
disodium phosphate          1%                                            
monosodium phosphate        0.5%                                          
polyvinyl alcohol           1.0%                                          
water                       56.7%                                         
______________________________________                                    
 
    
     The ingredients are blended and ground together in a sand mill to produce particles essentially all under 5 microns in size. 
     EXAMPLE 9 
     Solution 
     
         ______________________________________                                    
N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                    
                              5%                                          
isoxazolo[4,5-b] pyridine-3-sulfonamide                                   
water                        95%                                          
______________________________________                                    
 
    
     The salt is added directly to the water with stirring to produce the solution, which may then be package for use. 
     EXAMPLE 10 
     Low Strength Granule 
     
         ______________________________________                                    
N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                         
                          0.1%                                            
2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                            
sulfonamide                                                               
attapulgite granules      99.9%                                           
(U.S.S. 20-40 mesh)                                                       
______________________________________                                    
 
    
     The active ingredient is dissolved in a solvent and the solution is sprayed upon dedusted granules in a double-cone blender. After spraying of the solution has been completed, the material is warmed to evaporate the solvent. The material is allowed to cool and then packaged. 
     EXAMPLE 11 
     Granule 
     
         ______________________________________                                    
N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                    
                             80%                                          
isoxazolo[4,5-b] pyridine-3-sulfonamide                                   
wetting agent                 1%                                          
crude ligninsulfonate salt (containing                                    
                             10%                                          
5-20% of the natural sugars)                                              
attapulgite clay              9%                                          
______________________________________                                    
 
    
     The ingredients are blended and milled to pass through a 100 mesh screen. This material is then added to a fluid bed granulator, the air flow is adjusted to gently fluidize the material, and a fine spray of water is sprayed onto the fluidized material. The fluidization and spraying are continued until granules of the desired size range are made. The spraying is stopped, but fluidization is continued, optionally with heat, until the water content is reduced to the desired level, generally less than 1%. The material is then discharged, screened to the desired size range, generally 14-100 mesh (1410-149 microns), and packaged for use. 
     EXAMPLE 12 
     High Strength Concentrate 
     
         ______________________________________                                    
N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                         
                           99%                                            
2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                            
sulfonamide                                                               
silica aerogel            0.5%                                            
synthetic amorphous silica                                                
                          0.5%                                            
______________________________________                                    
 
    
     The ingredients are blended and ground in a hammer-mill to produce a material essentially all passing a U.S. Ser. No. 50 screen (0.3 mm opening). The concentrate may be formulated further if necessary. 
     EXAMPLE 13 
     Wettable Powder 
     
         ______________________________________                                    
N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                    
                             90%                                          
isoxazolo[4,5-b] pyridine-3-sulfonamide                                   
dioctyl sodium sulfosuccinate                                             
                            0.1%                                          
synthetic fine silica       9.9%                                          
______________________________________                                    
 
    
     The ingredients are blended and ground in a hammer-mill to produce particles essentially all below 100 microns. The material is sifted through a U.S.S. No. 50 screen and then packaged. 
     EXAMPLE 14 
     Wettable Powder 
     
         ______________________________________                                    
N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                         
                            40%                                           
2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                            
sulfonamide                                                               
sodium ligninsulfonate      20%                                           
montmorillonite clay        40%                                           
______________________________________                                    
 
    
     The ingredients are thoroughly blended, coarsely hammer-milled and then air-milled to produce particles essentially all blow 10 microns in size. The material is reblended and then packaged. 
     EXAMPLE 15 
     Oil Suspension 
     
         ______________________________________                                    
N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                    
                             35%                                          
isoxazolo[4,5-b] pyridine-3-sulfonamide                                   
blend of polyalcohol carboxylic                                           
                              6%                                          
esters and oil soluble petroleum                                          
sulfonates                                                                
xylene                       59%                                          
______________________________________                                    
 
    
     The ingredients are combined and ground together in a sand mill to produce particles essentially all below 5 microns. The product can be used directly, extended with oils, or emulsified in water. 
     EXAMPLE 16 
     Dust 
     
         ______________________________________                                    
N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-                         
                            10%                                           
2,4-dimethylpyrazolo[1,5-a] -1,3,5-triazine-8-                            
sulfonamide                                                               
attapulgite                 10%                                           
Pyrophyllite                80%                                           
______________________________________                                    
 
    
     The active ingredient is blended with attapulgite and then passed through a hammer-mill to produce particles substantially all below 200 microns. The ground concentrate is then blended with powdered pyrophyllite until homogeneous. 
     EXAMPLE 17 
     Emulsifiable Concentrate 
     
         ______________________________________                                    
N-[[(4-methoxy-6-methyl-2-pyrimidinyl)amino]carbonyl]-                    
                             10%                                          
isoxazolo[4,5-b] pyridine-3-sulfonamide                                   
chlorobenzene                84%                                          
sorbitan monostearate and polyoxyethylene                                 
                              6%                                          
condensates thereof                                                       
______________________________________                                    
 
    
     The ingredients are combined and stirred to produce a solution which can be emulsified in water for application. 
     Utility 
     The compounds of the present invention are expected to be active preemergent or postemergent herbicides or plant growth regulants. The rates of application for the compounds of the invention are determined by a number of factors, including their use as plant growth modifiers or as herbicides, the crop species involved, the types of weeds to be controlled, weather and climate, formulations selected, mode of application, amount of foliage present, etc. In general terms, the subject compounds should be applied at levels of around 0.001 to 20 kg/ha, the lower rates being suggested for use on lighter soils and/or those having a low organic matter content, for plant growth modification or for situations where only short-term persistence is required, such as a herbicide for fallow land. 
     The compounds of the invention may be used in combination with any other commercial herbicide, nonlimiting examples of which are listed below: 
     
         ______________________________________                                    
Common Name                                                               
          Chemical Name                                                   
______________________________________                                    
acetochlor                                                                
          2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-                         
          methylphenyl)acetamide                                          
acifluorfen                                                               
          5-[2-chloro-4-(trifluoromethyl)phenoxy]-                        
          2-nitrobenzoic acid                                             
acrolein  2-propenal                                                      
alachlor  2-chloro-N-(2,6-diethylphenyl-N-methoxy-                        
          methyl)acetamide                                                
ametryn   N-ethyl-N&#39;(1-methylethyl-6-(methylthio-                         
          1,3,5-triazine-2,4-diamine                                      
amitrole  1H-1,2,4-triazol-3-amine                                        
AMS       ammonium sulfamate                                              
asulam    methyl[(4-aminophenyl)sulfonyl]carbamate                        
atrazine  6-chloro-N-ethyl-N&#39;-(1-methylethyl)-1,3,5-                      
          triazine-2,4-diamine                                            
barban    4-chloro-2-butynyl 3-chlorocarbamate                            
benefin   N-butyl-N-ethyl-2,6-dinitro-4-(tri-                             
          fluoromethyl)benzenamine                                        
bensulfuron                                                               
          2-[[[[[4,6-dimethoxy-2-pyrimidinyl)amino]-                      
          carbonyl]amino]sulfonyl]methyl]benzoic                          
          acid                                                            
bensulide O,O-bis(1-methylethyl)S-[2-[(phenylsul-                         
          fonyl)amino]ethyl]phosphorodithioate                            
bentazon  3-(1-methylethyl)-(1H)-2,2,3-benzothia-                         
          diazin-4(3H)-one 2,2-dioxide                                    
benzofluor                                                                
          N-[4-(ethylthio)-2-(trifluoromethyl)-                           
          phenyl]methanesulfonamide                                       
benzoylprop                                                               
          N-benzoyl-N-(3,4-dichlorophenyl)-DL-                            
          alanine                                                         
bifenox   methyl 5-(2,4-dichlorophenoxy)-2-                               
          nitrobenzoate                                                   
bromacil  5-bromo-6-methyl-3-(1-methylpropyl)-                            
          2,4(1H,3H)pyrimidinedione                                       
bromoxynil                                                                
          3,5-dibromo-4-hydroxybenzonitrile                               
butachlor N-(butoxymethyl)-2-chloro-N-(2,6-diethyl-                       
          phenyl)acetamide                                                
buthidazole                                                               
          3-[5-(1,1-dimethylethyl)-1,3,4-thia-                            
          diazol-2-yl]-4-hyrdroxy-1-methyl-2-                             
          imidazolidinone                                                 
butralin  4-(1,1-dimethylethyl)-N-(1-methyl-                              
          propyl)-2,6-dinitrobenzenamine                                  
butylate  S-ethyl bis(2-methylpropyl)carbamothioate                       
cacodylic dimethyl arsinic oxide                                          
acid                                                                      
CDAA      2-chloro-N,N-di-2-propenylacetamide                             
CDEC      2-chloroallyl diethyldithiocarbamate                            
chloramben                                                                
          3-amino-2,5-dichlorobenzoic acid                                
chlorbromuron                                                             
          3-(4-bromo-3-chlorophenyl)-1-methoxy-1-                         
          methylurea                                                      
chlorimuron                                                               
          2-[ [[[4-chloro-6-methoxy-2-pyrimidinyl)-                       
ethyl     amino]carbonyl]amino] sulfonyl]benzoic                          
          acid, ethyl ester                                               
chloroxuron                                                               
          N&#39;-[4-(4-chlorophenoxy)phenyl]-N,N-                             
          dimethylurea                                                    
chlorpropham                                                              
          1-methyethyl 3-chlorophenylcarbamate                            
chlorsulfuron                                                             
          2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-                         
          triazin-2-yl)amino]carbonyl]benxene-                            
          sulfonamide                                                     
chlortoluron                                                              
          N&#39;-(3-chloro-4-methylphenyl-N&#39;,N&#39;-                              
          dimethylurea                                                    
cinmethylin                                                               
          exo-1-methyl-4-(1-methylethyl)-2-[(2-                           
          methylphenyl)methoxy]-7-oxabicyclo-                             
          [2.2.1]heptane                                                  
clethodim (E,E)-(±)-2-[1-[[(3-chloro-2-propenyl)-                      
          oxy]imino]propyl]-5-[2-(ethylthio)-                             
          propyl]-3-hydroxy-2-cyclohexen-1-one                            
clomazone 2-[(2-chlorophenyl)methyl]-4,4-dimethyl-                        
          3-isoxazolidinone                                               
cloproxydim                                                               
          (E,E)-2-[1-[[(3-chloro-2-propenyl)oxy)-                         
          imino]butyl]-5-[2-(ethylthio)propyl]-                           
          3-hydroxy-2-cyclohexen-1-one                                    
clopyralid                                                                
          3,6-dichloro-2-pyridinecarboxylic acid                          
CMA       calcium salt of MAA                                             
cyanazine 2-[[4-chloro-6-(ethylamino)-1,3,5-triazin-                      
          3-yl]amino]-2-methylpropanenitrile                              
cycloate  S-ethyl cyclohexanecarbamothioate                               
cycluron  3-cyclooctyl-1,1-dimethylurea                                   
cyperquat 1-methyl-4-phenylpyridinium                                     
cyprazine 2-chloro-4-(cyclopropylamino)-6-(iso-                           
          propylamino)-s-triazine                                         
cyprazole N-[5-(2-chloro-1,1-dimethylethyl)-1,3,4-                        
          thiadiazol-2-yl] cyclopropanecarbox-                            
          amide                                                           
cypromid  3&#39;,4&#39;-dichlorocyclopropanecarboxanilide                         
dalapon   2,2-dichloropropionic acid                                      
dazomet   tetrahydro-3,5-dimethyl-2H-1,3,5-thia-                          
          diazine-2-thione                                                
DCPA      dimethyl 2,3,5,6-tetrachloro-1,4-benzene-                       
          dicarboxylate                                                   
desmediphan                                                               
          ethyl [3-[[(phenylamino)carbonyl]oxy]-                          
          phenyl]carbamate                                                
desmetryn 2-(isopropylamino)-4-(methylamino)-6-                           
          methylthio)-s-triazine                                          
diallate  S-(2,3-dichlor-2-propenyl)bis(1-                                
          methylethyl)carbamothioate                                      
dicamba   3,6-dichloro-2-methoxybenzoic acid                              
dichlobenil                                                               
          2,6-dichlorobenzonitrile                                        
dichlorprop                                                               
          (±)-2-(2,4-dichlorphenoxy)propanoic                          
          acid                                                            
dichlofop (±)-2-[4-(2,4-dichlorophenoxy)phenoxy]-                      
          propanoic acid                                                  
diethatyl N-(chloroacetyl)-N-(2,6-diethylphenyl)-                         
          glycine                                                         
difenzoquat                                                               
          1,2-dimethyl-3,5-diphenyl-1H-pyrazolium                         
dinitramine                                                               
          N.sup.3,N.sup.3 -diethyl-2,4-dinitro-6-(trifluoro-              
          methyl)-1,3-benzenediamine                                      
dinoseb   2-(1-methylpropyl)-4,6-dinitrophenol                            
diphenamid                                                                
          N,N-dimethyl-α-phenylbenzeneacetamide                     
dipropetryn                                                               
          6-(ethylthio)-N,N&#39;-bis(1-methylethyl)-                          
          1,3,5-triazine-2,4-diamine                                      
diquat    6,7-dihydrodipyrido[1,2-α-2&#39;,1&#39;-c]-                       
          pyrazinediium ion                                               
diuron    N&#39;-(3,4-dichlorophenyl)-N,N-dimethylurea                        
DNOC      2-methyl-4,6-dinitrophenol                                      
DPX-M6316 3-[[[[(4-methoxy-6-methyl-1,3,5-triazin-                        
          2-yl)amino]carbonyl]amino]sulfonyl]-                            
          2-thiophenecarboxylic acid, methyl                              
          ester                                                           
DSMA      disodium salt of MAA                                            
endothall 7-oxabicyclo[2.2.1]heptane-2,3-dicarbox-                        
          ylic acid                                                       
EPTC      S-ethyl dipropylcarbamothioate                                  
ethalfluralin                                                             
          N-ethyl-N-(2-methyl-2-propenyl)-2,6-                            
          dinitro-4-(trifluoromethyl)-                                    
          benzenamine                                                     
ethofumesate                                                              
          (±)-2-ethoxy-2,3-dihydro-3,3-dimethyl-                       
          5-benzofuranyl methanesulfonate                                 
Express ®                                                             
          2-[[N-(4-methoxy-6-methyl-1,3,5-triazine-                       
          2-yl)-N-methylaminocarbonyl]amino-                              
          sulfonyl]benzoic acid, methyl ester                             
fenac     2,3,6-trichlorobenzeneacetic acid                               
fenoxaprop                                                                
          (±)-2-[4-[(6-chloro-2-benzoxazolyl)oxy]-                     
          phenoxy]propanoic acid                                          
fenuron   N,N-dimethyl-N&#39;-phenylurea                                      
fenuron TCA                                                               
          Salt of fenuron and TCA                                         
flamprop  N-benzoyl-N-(3-chloro-4-fluorophenyl)-                          
          DL-alanine                                                      
fluazifop (±)2-[4-[[5-(trifluoromethyl)-2-pyri-                        
          dinyl]oxy]phenoxy]propanoic acid                                
fluazifop-P                                                               
          (R)-2-[4-[[5-trifluoromethyl)-2-pyri-                           
          dinyl]oxy]phenoxy]propanoic acid                                
fluchloralin                                                              
          N-(2-chloroethyl)-2,6-dinitro-N-propyl-                         
          4-(trifluoromethyl)benzenamine                                  
fluometuron                                                               
          N,N-dimethyl-N&#39;-(3-(trifluoromethyl)-                           
          phenyl]urea                                                     
fluorochlor-                                                              
          3-chloro-4-(chloromethyl)-1-[3-trifluoro-                       
idone     methyl)phenyl]-2-pyrrolidinone                                  
fluorodifen                                                               
          p-nitrophenyl α,α,α-trifluoro-2-nitro-        
          p-tolyl ether                                                   
fluoroglycofen                                                            
          carboxymethyl 5-[2-chloro-4-(tri-                               
          fluoromethyl)phenoxy]-2-nitrobenzoate                           
fluridone 1-methyl-3-phenyl-5-[3-(trifluoro-                              
          methyl)phenyl]-4(1H)-pyridinone                                 
fomesafen 5-(2-chloro-4-trifluoromethylphenoxy)-                          
          N-methylsulfonyl-2-nitrobenzamide                               
fosamine  ethyl hydrogen (aminocarbonyl)-                                 
          phosphate                                                       
glyphosate                                                                
          N-(phosphonomethyl)glycine                                      
haloxyfop 2-[4-[[3-chloro-5-(trifluoromethyl)-2-                          
          pyridinyl]oxy]phenoxy]propanoic acid                            
hexaflurate                                                               
          potassium hexafluoroarsenate                                    
hexazinone                                                                
          3-cyclohexyl-6-(dimethylamino)-1-methyl-                        
          1,3,5-triazine-2,4(1H,3H)-dione                                 
imazametha-                                                               
          6-(4-isopropyl-4-methyl-5-oxo-2-                                
benz      imidazolin-2-yl)-m-toluic acid,                                 
          methyl ester and 6-(4-isopropyl)-                               
          4-methyl-5-oxo-2-imidazolin-2-yl-                               
          p-toluic acid, methyl ester                                     
imazapyr  (±)2-[4,5-dihydro-4-methyl-4-(1-methyl-                      
          ethyl)-5-oxo-1H-imidazol-2-yl]-3-                               
          pyridinecarboxylic acid                                         
imazaquin 2-(4,5-dihydro-4-methyl-4-(1-methyl-                            
          ethyl)-5-oxo-1H-imidazol-2-yl)-3-                               
          quinolinecarboxylic acid                                        
imazethapyr                                                               
          (±)-2-[4,5-dihydro-4-methyl-4-(1-methyl-                     
          ethyl)-5-oxo-1H-imidazol-2-yl]-5-                               
          ethyl-3-pyridinecarboxylic acid                                 
ioxynil   4-hydroxy-3,5-diiodobenzonitrile                                
isopropalin                                                               
          4-(1-methylethyl)-2,6-dinitro-N,N-                              
          dipropylbenzenamine                                             
isoproturon                                                               
          N-(4-isopropylphenyl)-N&#39;,N&#39;-dimethylurea                        
isouron   N&#39;-[5-(1,1-dimethyethyl)-3-isoxazolyl]-                         
          N,N-dimethylurea                                                
isoxaben  N-[3-(1-ethyl-1-methylpropyl)-5-                                
          isoxazolyl]-2,6-dimethoxybenzamide                              
karbutilate                                                               
          3-[[(dimethylamino)carbonyl]amino]phenyl-                       
          (1,1-dimethylethyl)carbamate                                    
lactofen  (±)-2-ethoxy-1-methyl-2-oxoethyl-5-[2-                       
          chloro-4-(trifluoromethyl)phenoxy]-                             
          2-nitrobenzoate                                                 
lenacil   3-cyclohexyl-6,7-dihydro-1H-cyclopenta-                         
          pyrimidine-2,4(3H,5H)-dione                                     
linuron   N&#39;-(3,4-dichlorophenyl)-N-methoxy-N-                            
          methylurea                                                      
MAA       methylarsonic acid                                              
MAMA      monoammonium salt of MAA                                        
MCPA      (4-chloro-2-methyl)phenoxy)acetic acid                          
MCPB      4-(4-chloro-2-methylphenoxy)butanoic                            
          acid                                                            
mecoprop  (±)-2-(4-chloro-2-methylphenoxy)-                            
          propanoic acid                                                  
mefluidide                                                                
          N-[(2,4-dimethyl-5-[[(trifluormethyl)-                          
          sulfonyl]amino]phenyl]acetamide                                 
methal-   N-(2-methyl-2-propenyl)-2,6-dinitro-N-                          
propalin  propyl-4-(trifluoromethyl)benzenamide                           
methabenz-                                                                
          1,3-dimethyl-3-(2-benzothiazolyl)urea                           
thiazuron                                                                 
metham    methylcarbamodithioic acid                                      
methazole 2-(3,4-dichlorophenyl)-4-methyl-1,2,4-                          
          oxadiazolidine-3,5-dione                                        
methoxuron                                                                
          N&#39;-(3-chloro-4-methoxyphenyl)N,N-                               
          dimethylurea                                                    
metolachlor                                                               
          2-chloro-N-(2-ethyl-6-methylphenyl)-N-                          
          (2-methoxy-1-methylethyl)acetamide                              
metribuzin                                                                
          4-amino-6-(1,1-dimethylethyl)-3-(methyl-                        
          thio)-1,2,4-triazin-5(4H)-one                                   
metsulfuron                                                               
          2- [[[[(4-methoxy-6-methyl-1,3,5-triazine-                      
methyl    methyl-2-yl)amino]carbonyl]amion]sul-                           
          fonyl]benzoic acid, methyl ester                                
MH        1,2-dihydro-3,6-pyridazinedione                                 
molinate  S-ethyl hexahydro-1H-azepine-1-carbo-                           
          thioate                                                         
monolinuron                                                               
          3-(p-chlorophenyl)-1-methoxy-1-methyl-                          
          urea                                                            
monuron   N&#39;(4-chlorophenyl)-N,N-dimethylurea                             
monuron TCA                                                               
          Salt of monuron and TCA                                         
MSMA      monosodium salt of MAA                                          
napropamide                                                               
          N,N-diethyl-2-(1-naphthalenyloxy)-                              
          propanamide                                                     
naptalam  2-[(1-naphthalenylamino)carbonyl]-                              
          benzoic acid                                                    
neburon   1-butyl-3-(3,4-dichlorophenyl)-1-methyl-                        
          urea                                                            
nitralin  4-(methylsulfonyl)-2,6-dinitro-N,N-                             
          dipropylaniline                                                 
nitrofen  2,4-dichloro-1-(4-nitrophenoxy)benzene                          
nitrofluorfen                                                             
          2-chloro-1-(4-nitrophenoxy)-4-(tri-                             
          fluoromethyl)benzene                                            
norea     N,N-dimethyl-N&#39;-(octahydro-4,7-methano-                         
          1H-inden-5-yl)urea 3aα,4α,5α,7α,7a.alpha
          .-                                                              
          isomer                                                          
norflurazon                                                               
          4-chloro-5-(methylamino)-2-(3-trifluoro-                        
          methyl)phenyl-3(2H)-pyridazinone                                
oryzalin  4-(dipropylamino)-3,5-dinitro-                                  
          benzenesulfonamide                                              
oxadiazon 3-[2,4-dichloro-5-(1-methylethoxy)-                             
          phenyl]-5-(1,1-dimethylethyl)-                                  
          1,3,4-oxadiazol-2-(3H)-one                                      
oxyflurofen                                                               
          2-chloro-1-(3-ethoxy-4-nitrophenoxy)-4-                         
          (trifluoromethyl)benzene                                        
paraquat  1,1&#39;-dimethyl-4,4&#39;-bipyridinium ion                             
pebulate  S-propyl butylethylcarbamothioate                               
pendimethalin                                                             
          N-(1-ethylpropyl)-3,4-dimethyl-2,6-                             
          dinitrobenzenamine                                              
perfluidone                                                               
          1,1,1-trifluoro-N-[2-methyl-4-(phenyl-                          
          sulfonyl)phenyl]methanesulfonamide                              
phenmedipham                                                              
          3-[(methoxycarbonyl)amino]phenyl(3-                             
          methylphenyl)carbamate                                          
picloram  4-amino-3,5,6-trichloro-2-pyridine-                             
          carboxylic acid                                                 
PPG-1013  5-(2-chloro-4-(trifluoromethyl)-                                
          phenoxy)-2-nitroacetophenone                                    
          oxime-0-acetic acid, methyl ester                               
procyazine                                                                
          2-[[4-chloro-6-(cyclopropylamino)-1,3,5-                        
          triazine-2-yl]amino]-2-methylpropane-                           
          nitrile                                                         
profluralin                                                               
          N-(cyclopropylmethyl)-2,6-dinitro-N-propyl-4-                   
          (trifluoromethyl)benzenamine                                    
prometon  6-methoxy-N,N&#39;-bis(1-methylethyl)-1,3,5-                        
          triazine-2,4-diamine                                            
prometryn N,N&#39;-bis(1-methylethyl)-6-(methylthio)-                         
          1,3,5-triazine-2,4-diamine                                      
pronamide 3,5-dichloro-N-(1,1-dimethyl-2-propyn-                          
          yl)benzamide                                                    
propachlor                                                                
          2-chloro-N-(1-methylethyl)-N-                                   
          phenylacetamide                                                 
propanil  N-(3&#39;,4&#39;-dichlorophenyl)propanamide                             
propazine 6-chloro-N,N&#39;-bis(1-methylethyl)-                               
          1,3,5-triazine-2,4-diamine                                      
propham   1-methylethyl phenylcarbamate                                   
prosulfalin                                                               
          N-[[4-(dipropylamino)-3,5-dinitro-                              
          phenyl]sulfonyl]-S,S-dimethylsulfil-                            
          imine                                                           
prynachlor                                                                
          2-chloro-N-(1-methyl-2-propynyl)acet-                           
          anilide                                                         
pyrazon   5-amino-4-chloro-2-phenyl-3(2H)-                                
          pyridazinone                                                    
quizalofop                                                                
          2-[4-(6-chlorquinoxalin-2-yloxy)phen-                           
ethyl     oxypropanoic acid, ethyl ester                                  
quizalofop                                                                
          (±)-2-[4-[(6-chloro-2-quinoxalinyl)-                         
          oxy]phenoxy]propanoic acid                                      
secbumeton                                                                
          N-ethyl-6-methoxy-N&#39;(1-methylpropyl)-                           
          1,3,5-triazine-2,4-diamine                                      
sethoxydim                                                                
          2-[1-(ethoxyimino)butyl]-5-[2-(ethyl-                           
          thio)propyl]-3-hydroxy-2-cyclohexene-                           
          1-one                                                           
siduron   N-(2-methylcyclohexyl)-N&#34;-phenylurea                            
simazine  6-chloro-N,N-&#39;-diethyl-1,3,5-triazine-                          
          2,4-diamine                                                     
sulfometuron                                                              
          2-[[[[(4,6-dimethyl-2-pyrimidinyl)-                             
methyl    amino]carbonyl]amino]sulfonyl]-                                 
          benzoic acid, methyl ester                                      
TCA       trichloroacetic acid                                            
tebuthiuron                                                               
          N-[5-(1,1-dimethylethyl)-1,3,4-thiadi-                          
          azol-2-yl]-N,N&#39;-dimethylurea                                    
terbacil  5-chloro-3-(1,1-dimethylethyl)-6-                               
          methyl-2,4(1H,3H)-pyrimidinedione                               
terbuchlor                                                                
          N-(butoxymethyl)-2-chloro-N-[2-(1,1-                            
          dimethylethyl)-6-methylphenyl]-                                 
          acetamide                                                       
terbuthyl-                                                                
          2-(tert-butylamino)-4-chloro-6-(ethyl-                          
azine     amino)-s-triazine                                               
terbutol  2,6-di-tert-butyl-p-tolyl methylcar-                            
          bamate                                                          
terbutryn N-(1,1-dimethylethyl)-N&#39;-ethyl-6-                               
          (methylthio)-1,3,5-triazine-                                    
          2,4-diamine                                                     
thiameturon                                                               
          3- [[[[(4-methoxy-6-methyl-1,3,5-                               
methyl    triazin-2-yl)amino]carbonyl]-                                   
          amino]sulfonyl]-2-thiophenecarboxylic                           
          acid, methyl ester                                              
thiobencarb                                                               
          S-[(4-chlorophenyl)methyl]diethylcar-                           
          bamothioate                                                     
triallate S-(2,3,3-trichloro-2-propenyl)bis(1-                            
          methylethyl)carbamothioate                                      
triclopyr [(3,5,6-trichloro-2-pyridinyl)-                                 
          oxy]acetic acid                                                 
tridiphane                                                                
          1-(3,5-dichlorophenyl)-2-(2,2,2-                                
          trichloroethyl)oxirane                                          
trifluralin                                                               
          2,6-dinitro-N,N-dipropyl-4-(tri-                                
          fluoromethyl)benzenamine                                        
trimeturon                                                                
          1-(p-chlorophenyl)-2,3,3-trimethylpseu-                         
          dourea                                                          
2,4-D     (2,4-dichlorophenoxy)acetic acid                                
2,4-DB    4-(2,4-dichlorphenoxy)butanoic acid                             
vernolate S-propyl dipropylthiocarbamothioate                             
xylachlor 2-chloro-N-(2,3-dimethylphenyl)-N-                              
          (1-methylethyl)acetamide                                        
______________________________________