Patent Publication Number: US-6656731-B1

Title: Nucleic acid catalysts with endonuclease activity

Description:
This patent application is a continuation-in-part of Eckstein et al., U.S. Ser. No. 09/444,209 filed Nov. 19, 1999, which is a continuation-in-part of Eckstein et al., U.S. Ser. No. 09/159,274 filed Sep. 22, 1998, now U.S. Pat. No. 6,127,173 which claims the benefit of Eckstein et al., U.S. Ser. No. 60/059,473 filed Sep. 22, 1997, all entitled “NUCLEIC ACID CATALYSTS WITH ENDONUCLEASE ACTIVITY”. Each of these applications is hereby incorporated by reference herein in its entirety including the drawings. 
     The Sequence Listing file named “MBHB00,884-C SequenceListing.txt” (313,506 bytes in size) submitted on Compact Disc-Recordable (CD-R) medium (entitled “010810 — 1001”) in compliance with 37 C.F.R. § 1.52(e) is incorporated herein by reference. 
    
    
     BACKGROUND OF THE INVENTION 
     This invention relates to nucleic acid molecules with catalytic activity and derivatives thereof. 
     The following is a brief description of enzymatic nucleic acid molecules. This summary is not meant to be complete but is provided only for understanding of the invention that follows. This summary is not an admission that all of the work described below is prior art to the claimed invention. 
     Enzymatic nucleic acid molecules (ribozymes) are nucleic acid molecules capable of catalyzing one or more of a variety of reactions, including the ability to repeatedly cleave other separate nucleic acid molecules in a nucleotide base sequence-specific manner. Such enzymatic nucleic acid molecules can be used, for example, to target virtually any RNA transcript (Zaug et al., 324 , Nature  429 1986; Cech, 260  JAMA  3030, 1988; and Jefferies et al., 17  Nucleic Acids Research  1371, 1989). 
     Because of their sequence-specificity, trans-cleaving enzymatic nucleic acid molecules show promise as therapeutic agents for human disease (Usman &amp; McSwiggen, 1995  Ann. Rep. Med. Chem . 30, 285-294; Christoffersen and Marr, 1995  J. Med. Chem . 38, 2023-2037). Enzymatic nucleic acid molecules can be designed to cleave specific RNA targets within the background of cellular RNA. Such a cleavage event renders the mRNA non-functional and abrogates protein expression from that RNA. In this manner, synthesis of a protein associated with a disease state can be selectively inhibited. 
     There are seven basic varieties of naturally occurring enzymatic RNAs. Each can catalyze the hydrolysis of RNA phosphodiester bonds in trans (and thus can cleave other RNA molecules) under physiological conditions. In general, enzymatic nucleic acids act by first binding to a target RNA. Such binding occurs through the target binding portion of a enzymatic nucleic acid which is held in close proximity to an enzymatic portion of the molecule that acts to cleave the target RNA. Thus, the enzymatic nucleic acid first recognizes and then binds a target RNA through complementary base pairing, and once bound to the correct site, acts enzymatically to cut the target RNA. Strategic cleavage of such a target RNA will destroy its ability to direct synthesis of an encoded protein. After an enzymatic nucleic acid has bound and cleaved its RNA target, it is released from that RNA to search for another target and can repeatedly bind and cleave new targets. 
     In addition, several in vitro selection (evolution) strategies (Orgel, 1979 , Proc. R. Soc. London , B 205, 435) have been used to evolve new nucleic acid catalysts capable of catalyzing a variety of reactions, such as cleavage and ligation of phosphodiester linkages and amide linkages, (Joyce, 1989 , Gene , 82, 83-87; Beaudry et al., 1992 , Science  257, 635-641; Joyce, 1992 , Scientific American  267, 90-97; Breaker et al., 1994 , TIBTECH  12, 268; Bartel et al., 1993 , Science  261:1411-1418; Szostak, 1993 , TIBS  17, 89-93; Kumar et al, 1995 , FASEB J ., 9, 1183; Breaker, 1996 , Curr. Op. Biotech ., 7, 442). 
     The enzymatic nature of a ribozyme is advantageous over other technologies, since the effective concentration of ribozyme necessary to effect a therapeutic treatment is generally lower than that of an antisense oligonucleotide. This advantage reflects the ability of the ribozyme to act enzymatically, Thus, a single ribozyme (enzymatic nucleic acid) molecule is able to cleave many molecules of target RNA. In addition, the ribozyme is a highly specific inhibitor, with the specificity of inhibition depending not only on the base-pairing mechanism of binding, but also on the mechanism by which the molecule inhibits the expression of the RNA to which it binds. That is, the inhibition is caused by cleavage of the RNA target and so specificity is defined as the ratio of the rate of cleavage of the targeted RNA over the rate of cleavage of non-targeted RNA. This cleavage mechanism is dependent upon factors additional to those involved in base pairing. Thus, it is thought that the specificity of action of a ribozyme is greater than that of antisense oligonucleotide binding the same RNA site. 
     The development of ribozymes that are optimal for catalytic activity would contribute significantly to any strategy that employs RNA-cleaving ribozymes for the purpose of regulating gene expression. The hammerhead ribozyme functions with a catalytic rate (k cat ) of ˜1 min −1  in the presence of saturating (10 mM) concentrations of Mg 2+  cofactor. However, the rate for this ribozyme in Mg 2+  concentrations that are closer to those found inside cells (0.5-2 mM) can be 10- to 100-fold slower. In contrast, the RNase P holoenzyme can catalyze pre-tRNA cleavage with a k cat  of ˜30 min −1  under optimal assay conditions. An artificial ‘RNA ligase’ ribozyme has been shown to catalyze the corresponding self-modification reaction with a rate of ˜100 min −1 . In addition, it is known that certain modified hammerhead ribozymes that have substrate binding arms made of DNA catalyze RNA cleavage with multiple turn-over rates that approach 100 min −1 . Finally, replacement of a specific residue within the catalytic core of the hammerhead with certain nucleotide analogues gives modified ribozymes that show as much as a 10-fold improvement in catalytic rate. These findings demonstrate that ribozymes can promote chemical transformations with catalytic rates that are significantly greater than those displayed in vitro by most natural self-cleaving ribozymes. It is then possible that the structures of certain self-cleaving ribozymes may be optimized to give maximal catalytic activity, or that entirely new RNA motifs can be made that display significantly faster rates for RNA phosphodiester cleavage. 
     An extensive array of site-directed mutagenesis studies have been conducted with the hammerhead ribozyme to probe relationships between nucleotide sequence and catalytic activity. These systematic studies have made clear that most nucleotides in the conserved core of the hammerhead ribozyme cannot be mutated without significant loss of catalytic activity. In contrast, a combinatorial strategy that simultaneously screens a large pool of mutagenized ribozymes for RNAs that retain catalytic activity could be used more efficiently to define immutable sequences and to identify new ribozyme variants. Although similar in vitro selection experiments have been conducted with the hammerhead ribozyme (Nakamaye &amp; Eckstein, 1994 , Biochemistry  33, 1271; Long &amp; Uhlenbeck, 1994 , Proc. Natl. Acad. Sci ., 91, 6977; Ishizaka et al., 1995 , BBRC  214, 403; Vaish et al., 1997 , Biochemistry  36, 6495), none of these efforts have successfully screened full-sized hammerhead ribozymes for all possible combinations of sequence variants that encompass the entire catalytic core. 
     The hammerhead ribozyme is one of the smallest ribozymes known and has thus attracted much attention for the study of structure-function relationships in catalytic. RNAs as well as for its potential for the sequence-specific inhibition of gene expression (Usman et al., supra). The hammerhead cleaves RNA sequence-specifically adjacent to the general triplet sequence NUX, where N is any nucleotide and X can be A, U or C. Cleavage behind a guanosine such as in GUG is very slow (4.3×10 −5  min −1 ) compared to the triplet substrate GUC (1 min −1 ) (Baidya et al., 1997 , Biochemistry  36, 1108). Although the X-ray structure of this ribozyme has been solved and a mechanism proposed (Pley et al., 1994  Nature , 372, 68; Scott et al., 1996 , Science  274, 2065), the question of what determines its specificity for the NUX sequence is still largely unresolved. One way of obtaining an insight into this problem might be to compare sequences of hammerhead ribozymes with different triplet cleaving specificities. In previous publications, it was demonstrated, using in vitro selection, that the native hammerhead sequence necessary to cleave a typical cleavage triplet, NUX, can not be altered (Nakamaye &amp; Eckstein, 1994 , Biochemistry  33, 1271; Long &amp; Uhlenbeck, 1994 , Proc. Natl. Acad. Sci ., 91, 6977; Ishizaka et al., 1995 , BBRC  214, 403; Vaish et al., 1997 , Biochemistry  36, 6495), indicating that nature has evolved a close to perfect GUC cleaver. It was of interest to see what changes have to be imposed on the native hammerhead sequence for it to cleave after AUG, which usually resists cleavage, and thus arrive at a ribozyme with a new specificity. To achieve this, an in vitro selection was undertaken, where the number of randomized positions in the starting pool corresponded to the number of nucleotides typically found in the core and stem-loop II region of a hammerhead ribozyme. This would allow all possible sequence permutations to be explored in the search for a hammerhead which is able to cleave behind AUG (Robertson &amp; Joyce, 1990 , Nature  344:6265 467-8; Ellington and Szostak, 1990; Tuerk &amp; Gold, 1990; Wright &amp; Joyce, 1997; Carmi et al., 1997; for reviews see Breaker, 1997; Abelson, 1996; Ellington, 1997; Chapman &amp; Szostak, 1994). Tang et al., 1997, RNA 3, 914, reported novel ribozyme sequences with endonuclease activity, where the authors used an in vitro selection approach to isolate these ribozymes. 
     The platelet derived growth factor (PDGF) system has served as a prototype for the identification of substrates of receptor tyrosine kinases. Certain enzymes become activated by the PDGF receptor kinase, including phospholipase C and phosphatidylinositol 3′ kinase, Ras guanosine triphosphate (GTPase) activating protein (GAP) and src-like tyrosine kinases. GAP regulates the function of the Ras protein. It stimulates the GTPase activity of the 21 kD Ras protein (Barbacid. 56  Ann. Rev. Biochem . 779, 1987). Microinjection of oncogenically activated Ras into NIH 3T3 cells induces DNA synthesis. Mutations that cause oncogenic activation of ras lead to accumulation of Ras bound to GTP, the active form of the molecule. These mutations block the ability of GAP to convert Ras to the inactive form. Mutations that impair the interactions of Ras with GAP also block the biological function of Ras. 
     While a number of ras alleles exist (N-ras, K-ras, H-ras) which have been implicated in carcinogenesis, the type most often associated with colon and pancreatic carcinomas is the K-ras. Ribozymes which are targeted to certain regions of the K-ras allelic mRNAs may also prove inhibitory to the function of the other allelic mRNAs of the N-ras and H-ras genes. 
     Transformation is a cumulative process whereby normal control of cell growth and differentiation is interrupted, usually through the accumulation of mutations affecting the expression of genes that regulate cell growth and differentiation. 
     Scanlon WO91/18625, WO91/18624, and WO91/18913 describe a specific hammerhead ribozyme effective to cleave RNA from the H-ras gene at codon 12 mutation. This ribozyme is said to inhibit H-ras expression in response to exogenous stimuli. 
     Thompson et al., U.S. Pat. Nos. 5,610,052 and 5,801,158, describes enzymatic RNA molecules against Ras. 
     Vaish et al., 1998  PNAS  95, 2158-2162, describes the in vitro selection of a hammerhead-like ribozyme with an extended range of cleavable triplets. 
     The references cited above are distinct from the presently claimed invention since they do not disclose and/or contemplate the catalytic nucleic acid molecules of the instant invention. 
     SUMMARY OF THE INVENTION 
     This invention relates to novel nucleic acid molecules with catalytic activity, which are particularly useful for cleavage of RNA or DNA. The nucleic acid catalysts of the instant invention are distinct from other nucleic acid catalysts known in the art. The nucleic acid catalysts of the instant invention do not share sequence homology with other known ribozymes. Specifically, nucleic acid catalysts of the instant invention are capable of catalyzing an intermolecular or intramolecular endonuclease reaction. 
     In a preferred embodiment, the invention features a nucleic acid molecule with catalytic activity having one of the formulae I-V:                    
     In each of the above formulae, N represents independently a nucleotide or a non-nucleotide linker, which may be the same or different; X and Y are independently oligonucleotides of length sufficient to stably interact (e.g., by forming hydrogen bonds with complementary nucleotides in the target) with a target nucleic acid molecule (the target can be an RNA, DNA or RNA/DNA mixed polymers); m and n are integers independently greater than or equal to 1 and preferably less than about 100, wherein if (N) m  and (N) n  are nucleotides, (N)m and (N)n are optionally able to interact by hydrogen bond interaction; J is an oligonucleotide of length 6 or 7 nucleotides; K is an oligonucleotide of length 5 nucleotides; L is a linker which may be present or absent (i.e., the molecule is assembled from two separate molecules), but when present, is a nucleotide and/or a non-nucleotide linker, which may be a single-stranded and/or double-stranded region; and  ———  represents a chemical linkage (e.g. a phosphate ester linkage, amide linkage or others known in the art). Z is independently a nucleotide numbered as 13.1 (FIG. 8) which can stably interact with a nucleotide at position 14.1 (FIG. 8) in the target nucleic acid molecule, preferably, the N 13.1 -N 14.1  interaction is inosine 13.1 -cytidine 14.1 ; adenosine 13.1 -uridine 14.1 ; guanosine 13.1 -cytidine 14.1 ; uridine 13.1 -adenosine 14.1 ; or cytidine 13.1 -guanosine 14.1 ; and C, G, A, and U represent cytidine, guanosine, adenosine and uridine nucleotides, respectively. The nucleotides in the each of the formulae I-V are unmodified or modified at the sugar, base, and/or phosphate as known in the art. 
     In a preferred embodiment, the invention features nucleic acid molecules of Formula I, where the sequence of oligonucleotide J is selected from the group comprising 5′-GGCAUCC-3′, 5′-AGCAUU-3′, 5′-GCAUCA-3′, 5′-AGCAUC-3′, and 5′-AGCGUC-3′. 
     In another preferred embodiment, the invention features nucleic acid molecules of Formula II, where the sequence of oligonucleotide J is 5′-GGAAUC-3′. 
     In a further preferred embodiment, the invention features nucleic acid molecules of Formula III, where the sequence of oligonucleotide K is selected from the group comprising 5′-UGAUG-3′, 5′-UGAUC-3′, and 5′-UGGGC-3′. 
     In another embodiment, the nucleotide linker (L) is a nucleic acid sequence selected from the group consisting of 5′-GCACU-3′, 5′-GAACU-3′, 5′-GCACC-3′, 5′-GNACU-3′, 5′-GNGCU-3′, 5′-GNCCU-3′, 5′-GNUCU-3′, 5′-GNGUU-3′, 5′-GNCUU-3′, 5′-GNUUU-3′, 5′-GNAUU-3′, 5′-GNACA-3′, 5′-GNGCA-3′, 5′-GNCCA-3′, and 5′-GNUCA-3′, whereby N can be selected from the group consisting of A, G, C, or U. 
     In yet another embodiment, the nucleotide linker (L) is a nucleic acid aptamer, such as an ATP aptamer, HIV Rev aptamer (RRE), HIV Tat aptamer (TAR) and others (for a review see Gold et al., 1995 , Annu. Rev. Biochem ., 64, 763; and Szostak &amp; Ellington, 1993, in  The RNA World , ed. Gesteland and Atkins, pp. 511, CSH Laboratory Press). A “nucleic acid aptamer” as used herein is meant to indicate a nucleic acid sequence capable of interacting with a ligand. The ligand can be any natural or a synthetic molecule, including but not limited to a resin, metabolites, nucleosides, nucleotides, drugs, toxins, transition state analogs, peptides, lipids, proteins, amino acids, nucleic acid molecules, hormones, carbohydrates, receptors, cells, viruses, bacteria and others. 
     In yet another embodiment, the non-nucleotide linker (L) is as defined herein. The term “non-nucleotide” as used herein include either abasic nucleotide, polyether, polyamine, polyamide, peptide, carbohydrate, lipid, or polyhydrocarbon compounds. Specific examples include those described by Seela and Kaiser,  Nucleic Acids Res . 1990, 18:6353 and  Nucleic Acids Res . 1987, 15:3113; Cload and Schepartz,  J. Am. Chem. Soc . 1991, 113:6324; Richardson and Schepartz,  J. Am. Chem. Soc . 1991, 113:5109; Ma et al.,  Nucleic Acids Res . 1993, 21:2585 and  Biochemistry  1993, 32:1751; Durand et al.,  Nucleic Acids Res . 1990, 18:6353; McCurdy et al.,  Nucleosides  &amp;  Nucleotides  1991, 10:287; Jschke et al.,  Tetrahedron Lett . 1993, 34:301; Ono et al.;  Biochemistry  1991, 30:9914; Arnold et al., International Publication No. WO 89/02439; Usman et al., International Publication No. WO 95/06731; Dudycz et al., International Publication No. WO 95/11910 and Ferentz and Verdine,  J. Am. Chem. Soc . 1991, 113:4000, all hereby incorporated by reference herein. Thus, in a preferred embodiment, the invention features an enzymatic nucleic acid molecule having one or more non-nucleotide moieties, and having enzymatic activity to cleave an RNA or DNA molecule. By the term “non-nucleotide” is meant any group or compound which can be incorporated into a nucleic acid chain in the place of one or more nucleotide units, including either sugar and/or phosphate substitutions, and allows the remaining bases to exhibit their enzymatic activity. The group or compound is abasic in that it does not contain a commonly recognized nucleotide base, such as adenine, guanine, cytosine, uracil or thymine. The terms “abasic” or “abasic nucleotide” as used herein encompass sugar moieties lacking a base or having other chemical groups in place of a base at the 1′ position. 
     In preferred embodiments, the enzymatic nucleic acid includes one or more stretches of RNA, which provide the enzymatic activity of the molecule, linked to the non-nucleotide moiety. The necessary RNA components are known in the art (see for e.g., Usman et al., supra). By RNA is meant a molecule comprising at least one ribonucleotide residue. By “ribonucleotide” is meant a nucleotide with a hydroxyl group at the 2′ position of a β-D-ribo-furanose moiety. 
     Thus, in one preferred embodiment, the invention features ribozymes that inhibit gene expression and/or cell proliferation. These chemically or enzymatically synthesized nucleic acid molecules contain substrate binding domains that bind to accessible regions of specific target nucleic acid molecules. The nucleic acid molecules also contain domains that catalyze the cleavage of target. Upon binding, the enzymatic nucleic acid molecules cleave the target molecules, preventing, for example, translation and protein accumulation. In the absence of the expression of the target gene, cell proliferation, for example, is inhibited. In another aspect of the invention, enzymatic nucleic acid molecules that cleave target molecules are expressed from transcription units inserted into DNA or RNA vectors. The recombinant vectors are preferably DNA plasmids or viral vectors. Ribozyme expressing viral vectors could be constructed based on, but not limited to, adeno-associated virus, retrovirus, adenovirus, or alphavirus. Preferably, the recombinant vectors capable of expressing the ribozymes are delivered as described below, and persist in target cells. Alternatively, viral vectors may be used that provide for transient expression of ribozymes. Such vectors can be repeatedly administered as necessary. Once expressed, the ribozymes cleave the target mRNA. Delivery of ribozyme expressing vectors can be systemic, such as by intravenous or intramuscular administration, by administration to target cells ex-planted from the patient followed by reintroduction into the patient, or by any other means that would allow for introduction into the desired target cell (for a review, see, Couture and Stinchcomb, 1996 , TIG ., 12, 510). 
     As used in herein “cell” is used in its usual biological sense, and does not refer to an entire multicellular organism, e.g., specifically does not refer to a human. The cell may be present in a non-human multicellular organism, e.g., birds, plants and mammals such as cows, sheep, apes, monkeys, swine, dogs, and cats. 
     In a preferred embodiment, an expression vector comprising a nucleic acid sequence encoding at least one of the nucleic acid catalysts of the instant invention is disclosed. The nucleic acid sequence encoding the nucleic acid catalyst of the instant invention is operable linked in a manner which allows expression of that nucleic acid molecule. 
     In one embodiment, the expression vector comprises: a transcription initiation region (e.g., eukaryotic pol I, II or III initiation region); b) a transcription termination region (e.g., eukaryotic pol I, II or III termination region); c) a nucleic acid sequence encoding at least one of the nucleic acid catalyst of the instant invention; and wherein said gene is operably linked to said initiation region and said termination region, in a manner which allows expression and/or delivery of said nucleic acid molecule. The vector may optionally include an open reading frame (ORF) for a protein operably linked on the 5′ side or the 3′-side of the sequence encoding the nucleic acid catalyst of the invention; and/or an intron (intervening sequences). 
     By “patient” is meant an organism which is a donor or recipient of explanted cells or the cells themselves. “Patient” also refers to an organism to which enzymatic nucleic acid molecules can be administered. Preferably, a patient is a mammal or mammalian cells. More preferably, a patient is a human or human cells. 
     By “vectors” is meant any nucleic acid- and/or viral-based technique used to deliver a desired nucleic acid. 
     Another means of accumulating high concentrations of a ribozyme(s) within cells is to incorporate the ribozyme-encoding sequences into a DNA or RNA expression vector. Transcription of the ribozyme sequences are driven from a promoter for eukaryotic RNA polymerase. I (pol I), RNA polymerase II (pol II), or RNA polymerase III (pol III). Transcripts from pol II or pol III promoters will be expressed at high levels in all cells; the levels of a given pol II promoter in a given cell type will depend on the nature of the gene regulatory sequences (enhancers, silencers, etc.) present nearby. Prokaryotic RNA polymerase promoters are also used, providing that the prokaryotic RNA polymerase enzyme is expressed in the appropriate cells (Elroy-Stein and Moss, 1990  Proc. Natl. Acad. Sci. USA , 87, 6743-7; Gao and Huang 1993  Nucleic Acids Res ., 21, 2867-72; Lieber et al., 1993  Methods Enzymol ., 217, 47-66; Zhou et al., 1990  Mol. Cell. Biol ., 10, 4529-37). Several investigators have demonstrated that ribozymes expressed from such promoters can function in mammalian cells (e.g. Kashani-Sabet et al., 1992  Antisense Res. Dev ., 2, 3-15; Ojwang et al., 1992  Proc. Natl. Acad. Sci. USA , 89, 10802-6; Chen et al., 1992  Nucleic Acids Res ., 20, 4581-9; Yu et al., 1993  Proc. Natl. Acad. Sci. USA , 90, 6340-4; L&#39;Huillier et al., 1992  EMBO J . 11, 4411-8; Lisziewicz et al., 1993  Proc. Natl. Acad. Sci. U. S. A ., 90, 8000-4; Thompson et al., 1995  Nucleic Acids Res . 23, 2259; Sullenger &amp; Cech, 1993 , Science 262, 1566). The above ribozyme transcription units can be incorporated into a variety of vectors for introduction into mammalian cells, including but not restricted to, plasmid DNA vectors, viral DNA vectors (such as adenovirus or adeno-associated virus vectors), or viral RNA vectors (such as retroviral or alphavirus vectors) (for a review see Couture and Stinchcomb, 1996, supra). 
     In another preferred embodiment, catalytic activity of the molecules described in the instant invention can be optimized as described by Draper et al., supra. The details will not be repeated here, but include altering the length of the ribozyme binding arms, or chemically synthesizing ribozymes with modifications (base, sugar and/or phosphate) that prevent their degradation by serum ribonucleases and/or enhance their enzymatic activity (see e.g., Eckstein et al., International Publication No. WO 92/07065; Perrault et al., 1990  Nature  344, 565; Pieken et al., 1991  Science  253, 314; Usman and Cedergren, 1992  Trends in Biochem. Sci . 17, 334; Usman et. al., International Publication No. WO 93/15187; and Rossi et al., International Publication No. WO 91/03162; Sproat, U.S. Pat. No. 5;334,711; and Burgin et al., supra; all of these describe various chemical modifications that can be made to the base, phosphate and/or sugar moieties of enzymatic RNA molecules). Modifications to the molecules, which enhance their efficacy in cells, and removal of bases from stem loop structures to shorten RNA synthesis times and reduce chemical requirements are desired. All these publications are hereby incorporated by reference herein. 
     By “enhanced enzymatic activity” is meant to include activity measured in cells and/or in vivo where the activity is a reflection of both catalytic activity and ribozyme stability. In this invention, the product of these properties is increased or not significantly (less than 10-fold) decreased in vivo compared to an all RNA ribozyme. 
     In yet another preferred embodiment, nucleic acid catalysts having chemical modifications, which maintain or enhance enzymatic activity are provided. Such nucleic acid is also generally more resistant to nucleases than unmodified nucleic acid. Thus, in a cell and/or in vivo the activity may not be significantly lowered. As exemplified herein, such ribozymes are useful in a cell and/or in vivo even if activity over all is reduced 10 fold (Burgin et al., 1996 , Biochemistry , 35, 14090). Such ribozymes herein are said to “maintain” the enzymatic activity of an all RNA ribozyme. 
     In yet another aspect the invention features an enzymatic nucleic acid molecule which cleaves mRNA produced from the human K-ras gene (accession NM — 004985), H-ras gene (accession NM — 005343) or N-ras gene (accession NM — 002524). In one nonlimiting example, the enzymatic nucleic acid molecule of the present invention cleaves mRNA molecules associated with the development or maintenance of colon carcinoma. In preferred embodiments, the enzymatic nucleic acid molecules comprise sequences which are complementary to the substrate sequences in Table II. Examples of such enzymatic nucleic acid molecules also are shown in Table II. Examples of such enzymatic nucleic acid molecules consist essentially of sequences defined in Table II. 
     Other features and advantages of the invention will be apparent from the following description of the preferred embodiments thereof, and from the claims. 
     DESCRIPTION OF THE PREFERRED EMBODIMENTS 
     The drawings will first briefly be described. 
     DRAWINGS 
     FIG. 1 A) is a diagrammatic representation of the hammerhead ribozyme domain known in the art. Stem II can be 2 base-pairs long. Each N is independently any base or non-nucleotide as used herein; B) is a diagrammatic representation of a self-cleaving hammerhead ribozyme; C) is a diagrammatic representation of a random pool of self-cleaving RNA. N indicates the region with random nucleotides. (SEQ ID NO: 1171-1174) 
     FIG. 2 is a schematic representation of a non-limiting in vitro selection strategy used to evolve nucleic acid catalysts. (SEQ ID NO: 1175-1189) 
     FIG. 3 shows sequences of individual RNAs that represent new classes of self-cleaving ribozymes. Also shown are rates of catalysis (k in-cis  (min −1 )) for each of the new self-cleaving RNA sequences. The underlined sequences indicate the regions capable of interacting with each other. (SEQ ID NO: 1175-1189) 
     FIG. 4 summarizes structure mapping studies on clone 40 RNA. (SEQ ID NO: 1190) 
     FIG. 5 shows sequence and possible secondary structure of a trans-cleaving ribozyme of the invention. Arrow identifies the site of cleavage. (SEQ ID NO: 1191-1192) 
     FIG. 6 shows non-limiting examples of trans-cleaving ribozyme-substrate complex of the present invention. (SEQ ID NO: 1193-1198) 
     FIG. 7 shows non-limiting examples of chemically modified trans-cleaving ribozyme-substrate complex of the present invention. (SEQ ID NO: 1199-1206) 
     FIG. 8 shows a non-limiting example of a chemically modified trans-cleaving ribozyme-substrate complex of the present invention and the numbering system used for (SEQ ID NO: 1207-1208) 
    
    
     NUCLEIC ACID CATALYSTS 
     The invention provides nucleic acid catalysts and methods for producing a class of enzymatic nucleic acid cleaving agents which exhibit a high degree of specificity for the nucleic acid sequence of a desired target. The enzymatic nucleic acid molecule is preferably targeted to a highly conserved sequence region of a target such that specific diagnosis and/or treatment of a disease or condition in a variety of biological system can be provided with a single enzymatic nucleic acid. Such enzymatic nucleic acid molecules can be delivered exogenously to specific cells as required. In the preferred hammerhead motif, the small size (less than 60 nucleotides, preferably between 30-40 nucleotides in length) of the molecule allows the cost of treatment to be reduced. 
     By “nucleic acid catalyst” as used herein is meant a nucleic acid molecule (e.g., the molecule of formulae I-V), capable of catalyzing (altering the velocity and/or rate of) a variety of reactions including the ability to repeatedly cleave other separate nucleic acid molecules (endonuclease activity) in a nucleotide base sequence-specific manner. Such a molecule with endonuclease activity may have complementarity in a substrate binding region (e.g. X and Y in formulae I-V) to a specified-gene target, and also has an enzymatic activity that specifically cleaves RNA or DNA in that target. That is, the nucleic acid molecule with endonuclease activity is able to intramolecularly or intermolecularly cleave RNA or DNA and thereby inactivate a target RNA or DNA molecule. This complementarity functions to allow sufficient hybridization of the enzymatic RNA molecule to the target RNA or DNA to allow the cleavage to occur. 100% complementarity is preferred, but complementarity as low as 50-75% may also be useful in this invention. The nucleic acids may be modified at the base, sugar, and/or phosphate groups. The term enzymatic nucleic acid is used interchangeably with phrases such as ribozymes, catalytic RNA, enzymatic RNA, catalytic DNA, nucleozyme, RNA enzyme, endoribonuclease, endonuclease, minizyme, oligozyme, finderon or nucleic acid catalyst. All of these terminologies describe nucleic acid molecules with enzymatic activity. The specific examples of enzymatic nucleic acid molecules described in the instant application are not limiting in the invention and those skilled in the art will recognize that all that is important in an enzymatic nucleic acid molecule of this invention is that it has a specific substrate binding site which is complementary to one or more of the target nucleic acid regions, and that it have nucleotide sequences within or surrounding that substrate binding site which impart a nucleic acid cleaving activity to the molecule. 
     By “nucleic acid molecule” as used herein is meant a molecule having nucleotides. The nucleic acid can be single, double, or multiple stranded and may comprise modified or unmodified nucleotides or non-nucleotides or various mixtures and combinations thereof. 
     By “complementarity” is meant that a nucleic acid can form hydrogen bond(s) with another RNA sequence by either traditional Watson-Crick or other non-traditional types. In reference to the nucleic molecules of the present invention, the binding free energy for a nucleic acid molecule with its target or complementary sequence is sufficient to allow the relevant function of the nucleic acid to proceed, e.g., enzymatic nucleic acid cleavage, antisense or triple helix inhibition. Determination of binding free energies for nucleic acid molecules is well-known in the art (see, e.g., Turner et al., 1987 , CSH Symp. Quant. Biol . LII pp.123-133; Frier et al., 1986 , Proc. Nat. Acad. Sci. USA  83:9373-9377; Turner et al., 1987 , J. Am. Chem. Soc . 109:3783-3785. A percent complementarity indicates the percentage of contiguous residues in a nucleic acid molecule which can form hydrogen bonds (e.g., Watson-Crick base pairing) with a second nucleic acid sequence (e.g., 5, 6, 7, 8, 9, 10 out of 10 being 50%, 60%, 70%, 80%, 90%, and 100% complementary). “Perfectly complementary” means that all the contiguous residues of a nucleic acid sequence will hydrogen bond with the same number of contiguous residues in a second nucleic acid sequence. 
     The enzymatic nucleic acid molecules of Formulae I-V may independently comprise a cap structure which may independently be present or absent. 
     By “sufficient length” is meant an oligonucleotide of greater than or equal to 3 nucleotides. For example, for the X and Y portions of the nucleic acid molecules disclosed in formulae I-V “sufficient length” means that the nucleotide length is long enough to provide stable binding to a target site under the expected binding conditions. Preferably, the X and Y portions are not so long as to prevent useful turnover. 
     By “stably interact” is meant, interaction of the oligonucleotides with target nucleic acid (e.g., by forming hydrogen bonds with complementary nucleotides in the target under physiological conditions). 
     By “chimeric nucleic acid molecule” or “mixed polymer” is meant that, the molecule may be comprised of both modified or unmodified nucleotides. 
     By “cap structure” is meant chemical modifications, which have been incorporated at either terminus of the oligonucleotide. These terminal modifications protect the nucleic acid molecule from exonuclease degradation, and may help in delivery and/or localization within a cell. The cap may be present at the 5′-terminus. (5′-cap) or at the 3′-terminus (3′-cap) or may be present on both termini. In non-limiting examples: the 5′-cap is selected from the group comprising inverted abasic residue (moiety); 4′,5′-methylene nucleotide; 1-(beta-D-erythrofuranosyl) nucleotide; 4′-thio nucleotide, carbocyclic nucleotide; 1,5-anhydrohexitol nucleotide; L-nucleotides; alpha-nucleotides; modified base nucleotide; phosphorodithioate linkage; threo-pentofuranosyl nucleotide; acyclic 3′,4′-seco nucleotide; acyclic 3,4-dihydroxybutyl nucleotide; acyclic 3,5-dihydroxypentyl nucleotide, 3′-3′-inverted nucleotide moiety; 3′-3′-inverted abasic moiety; 3′-2′-inverted nucleotide moiety; 3′-2′-inverted abasic moiety; 1,4-butanediol phosphate; 3′-phosphoramidate; hexylphosphate; aminohexyl phosphate; 3′-phosphate; 3′-phosphorothioate; phosphorodithioate; or bridging or non-bridging methylphosphonate moiety (for more details see Beigelman et al., International PCT publication No. WO 97/26270, incorporated by reference herein). 
     In yet another preferred embodiment the 3′-cap is selected from a group comprising, 4′,5′-methylene nucleotide; 1-(beta-D-erythrofuranosyl) nucleotide; 4′-thio nucleotide, carbocyclic nucleotide; 5′-amino-alkyl phosphate; 1,3-diamino-2-propyl phosphate, 3-aminopropyl phosphate; 6-aminohexyl phosphate; 1,2-aminododecyl phosphate; hydroxypropyl phosphate; 1,5-anhydrohexitol nucleotide; L-nucleotide; alpha-nucleotide; modified base nucleotide; phosphorodithioate; threo-pentofuranosyl nucleotide; acyclic 3′,4′-seco nucleotide; 3,4-dihydroxybutyl nucleotide; 3,5-dihydroxypentyl nucleotide, 5′-5′-inverted nucleotide moiety; 5′-5′-inverted abasic moiety; 5′-phosphoramidate; 5′-phosphorothioate; 1,4-butanediol phosphate; 5′-amino; bridging and/or non-bridging 5′-phosphoramidate, phosphorothioate and/or phosphorodithioate, bridging or non bridging methylphosphonate and 5′-mercapto moieties (for more details, see, Beaucage and Iyer, 1993 , Tetrahedron  49, 1925; incorporated by reference herein). 
     By the term “non-nucleotide” is meant any group or compound which can be incorporated into a nucleic acid chain in the place of one or more nucleotide units, including either sugar and/or phosphate substitutions, and allows the remaining bases to exhibit their enzymatic activity. The group or compound is abasic in that it does not contain a commonly recognized nucleotide base, such as adenosine, guanine, cytosine, uracil or thymine. The terms “abasic” or “abasic nucleotide” as used herein encompass sugar moieties lacking a base or having other chemical groups in place of base at the 1′ position. 
     By “oligonucleotide” as used herein, is meant a molecule comprising two or more nucleotides. 
     The specific enzymatic nucleic acid molecules described in the instant application are not limiting in the invention and those skilled in the art will recognize that all that is important in an enzymatic nucleic acid molecule of this invention is that it has a specific substrate binding site (e.g., X and Y of Formulae I-V above) which is complementary to one or more of the target nucleic acid regions, and that it have nucleotide sequences within or surrounding that substrate binding site which impart a nucleic acid cleaving activity to the molecule. 
     By “enzymatic portion” is meant that part of the ribozyme essential for cleavage of an RNA substrate. 
     By “substrate binding arm” or “substrate binding domain” is meant that portion of a ribozyme which is complementary to (i.e., able to base-pair with) a portion of its substrate. Generally, such complementarity is 100%, but can be less if desired. For example, as few as 10 nucleotides out of a total of 14 may be base-paired. Such arms are shown generally in FIG.  1 A and as X and Y in Formulae I-V. That is, these arms contain sequences within a ribozyme which are intended to bring ribozyme and target RNA together through complementary base-pairing interactions. The ribozyme of the invention may have binding arms that are contiguous or non-contiguous and may be of varying lengths. The length of the binding arm(s) are preferably greater than or equal to four nucleotides; specifically 12-100 nucleotides; more specifically 14-24 nucleotides long. The two binding arms are chosen, such that the length of the binding arms are symmetrical (i.e., each of the binding arms is of the same length; e.g., five and five nucleotides, six and six nucleotides or seven and seven nucleotides long) or asymmetrical (i e., the binding arms are of different length; e.g., six and three nucleotides; three and six nucleotides long; four and five nucleotides long; four and six nucleotides long; four and seven nucleotides long; and the like). 
     Catalytic activity of the ribozymes described in the instant invention can be optimized as described by Draper et al., supra. The details will not be repeated here, but include altering the length of the ribozyme binding arms, or chemically synthesizing ribozymes with modifications (base, sugar and/or phosphate) that prevent their degradation by serum ribonucleases and/or enhance their enzymatic activity (see e.g. Eckstein et al., International Publication No. WO 92/07065; Perrault et al., 1990  Nature  344, 565; Pieken et al., 1991  Science  253, 314, Usman and Cedergren, 1992  Trends in Biochem. Sci . 17, 334; Usman et al., International Publication No. WO 93/15187; and Rossi et al., International Publication No. WO 91/03162; Sproat, U.S. Pat. No. 5,334,711; and Burgin et al., supra; all of these describe various chemical modifications that can be made to the base, phosphate and/or sugar moieties of enzymatic RNA molecules). Modifications which enhance their efficacy in cells, and removal of bases from stem loop structures to shorten RNA synthesis times and reduce chemical requirements are desired. All these publications are hereby incorporated by reference herein. 
     Therapeutic ribozymes must remain stable within cells until translation of the target RNA has been inhibited long enough to reduce the levels of the undesirable protein. This period of time varies between hours to days depending upon the disease state. Clearly, ribozymes must be resistant to nucleases in order to function as effective intracellular therapeutic agents. Improvements in the chemical synthesis of RNA (Wincott et al., 1995  Nucleic Acids Res . 23, 2677; incorporated by reference herein) have expanded the ability to modify ribozymes to enhance their nuclease stability. The term “nucleotide” is used as recognized in the art to include natural bases, and modified bases well known in the art. Such bases are generally located at the 1′ position of a sugar moiety. Nucleotides generally comprise a base, sugar and a phosphate group. The nucleotides can be unmodified or modified at the sugar, phosphate and/or base moiety, (see for example, Usman and McSwiggen, supra; Eckstein et al., International PCT Publication No. WO 92/07065; Usman et al., International PCT Publication No. WO 93/15187; all hereby incorporated by reference herein). There are several examples of modified nucleic acid bases known in the art. These recently have been summarized by Limbach et al., 1994 , Nucleic Acids Res . 22, 2183. Some of the non-limiting examples of base modifications that can be introduced into enzymatic nucleic acids without significantly effecting their catalytic activity include, inosine, purine, pyridin-4-one, pyridin-2-one, phenyl, pseudouracil, 2, 4, 6-trimethoxy benzene, 3-methyluracil, dihydrouridine, naphthyl, aminophenyl, 5-alkylcytidines (e.g., 5-methylcytidine), 5-alkyluridines (e.g., ribothymidine), 5-halouridine (e.g., 5-bromouridine) or 6-azapyrimidines or 6-alkylpyrimidines (e.g. 6-methyluridine) and others (Burgin et al., 1996 , Biochemistry , 35, 14090). By “modified bases” in this aspect is meant nucleotide bases other than adenine, guanine, cytosine and uracil at 1′ position or their equivalents; such bases may be used within the catalytic core of the enzyme and/or in the substrate-binding regions. 
     In a preferred embodiment, the invention features modified ribozymes with phosphate backbone modifications comprising one or.more phosphorothioate and/or phosphorodithioate substitutions. A non-limiting, preferred example of a ribozyme of the instant invention utilizing phosphorothioate and/or phosphorodithioate modifications in conjunction with 2′-O-methyl ribonucleotides and conserved ribonucleotide residues is shown in FIG.  8 . The incorporation of phosphorothioate and/or phosphorodithioate linkages into the enzymatic nucleic acid of the instant invention results in increased serum stability. Replacement of the 3′-phosphodiester at position 6 with a phosphorothioate or phosphorodithioate linkage (FIG. 8) stabilizes the conserved position 6 ribose moiety, which is prone to nucleolytic cleavage. In a study investigating the serum stability of position 6 modified ribozyme variants which preserve the 2′-hydroxyl function at position 6 (FIG.  8 ), the relative stability of the modifications were ranked as follows: 
     
       
         3′-Phosphorodithioate&gt;&gt;3′-Phosphorothioate&gt;&gt;4′-Thioribofuranose&gt;Phosphodiester 
       
     
     The preferred incorporation of one to four, but preferably two, phosphorothioate linkages at the 5′-end of the position 6 3′-phosphorothioate ribozyme (FIG. 8) does not significantly affect the cleavage rate of the molecule. In a comparison study, the incorporation of up to four phosphorothioate residues at the 5′-end of this molecule is well tolerated. The incorporation of a 3′-phosphorodithioate residue at.position 6 of the ribozyme results in a 50% reduction in catalytic activity over the corresponding position 6 3′-phosphorothioate derivative. The loss of catalytic activity in the case of the position 6 3′-phosphorodithoate substitution may be offset by the increased serum stability that this modification offers and is likely to enhance the effectiveness of the ribozyme in cells. 
     In a preferred embodiment, the invention features a 3′-phosphorothioate linkage at position 6 of the nucleic acid molecule of the instant invention (FIG.  8 ). 
     In yet another preferred embodiment, the invention features a 3′-phosphorodithioate linkage at position 6 of the nucleic acid molecule (FIG.  8 ). 
     In a further preferred embodiment of the instant invention, an inverted deoxy abasic moiety is utilized at the 3′ end of the enzymatic nucleic acid molecule. 
     In particular, the invention features modified ribozymes having a base substitution selected from pyridin-4-one, pyridin-2-one, phenyl, pseudouracil, 2, 4, 6-trimethoxy benzene, 3-methyluracil, dihydrouracil, naphthyl, 6-methyl-uracil and aminophenyl. 
     There are several examples in the art describing sugar and phosphate modifications that can be introduced into enzymatic nucleic acid molecules without significantly effecting catalysis and with significant enhancement in their nuclease stability and efficacy. Ribozymes are modified to enhance stability and/or enhance catalytic activity by modification with nuclease resistant groups, for example, 2′-amino, 2′-C-allyl, 2′-flouro, 2′-O-methyl, 2′-H, nucleotide base modifications (for a review see Usman and Cedergren, 1992  TIBS  17, 34; Usman et al., 1994  Nucleic Acids Symp. Ser . 31, 163; Burgin et al., 1996  Biochemistry  35, 14090). Sugar modifications of enzymatic nucleic acid molecules have been extensively described in the art (see Eckstein et al.,  International Publication  PCT No. WO 92/07065; Perrault et al.  Nature  1990, 344, 565-568; Pieken et al.  Science  1991, 253, 314-317; Usman and Cedergren,  Trends in Biochem. Sci . 1992, 17, 334-339; Usman et al.  International Publication  PCT No. WO 93/15187; Sproat, U.S. Pat. No. 5,334,711 and Beigelman et al., 1995  J. Biol. Chem . 270, 25702). 
     Such publications describe general methods and strategies to determine the location of incorporation of sugar, base and/or phosphate modifications and the like into ribozymes without inhibiting catalysis, and are incorporated by reference herein. In view of such teachings, similar modifications can be used as described herein to modify the nucleic acid catalysts of the instant invention. 
     As the term is used in this application, non-nucleotide-containing enzymatic nucleic acid means a nucleic acid molecule that contains at least one non-nucleotide component which replaces a portion of a ribozyme, e.g., but not limited to, a double-stranded stem, a single-stranded “catalytic core” sequence, a single-stranded loop or a single-stranded recognition sequence. These molecules are able to cleave (preferably, repeatedly cleave) separate RNA or DNA molecules in a nucleotide base sequence specific manner. Such molecules can also act to cleave intramolecularly if that is desired. Such enzymatic molecules can be targeted to virtually any RNA transcript. 
     The sequences of ribozymes that are chemically synthesized, useful in this invention, are shown in Table II. Those in the art will recognize that these sequences are representative only of many more such sequences where the enzymatic portion of the enzymatic nucleic acid molecule (all but the binding arms) is altered to affect activity. The ribozyme sequences listed in Table II may be formed of ribonucleotides or other nucleotides or non-nucleotides. Such ribozymes with enzymatic activity are equivalent to the ribozymes described specifically in the Table. 
     Synthesis of Nucleic Acid Molecules 
     Synthesis of nucleic acids greater than 100 nucleotides in length is difficult using automated methods, and the therapeutic cost of such molecules is prohibitive. In this invention, small nucleic acid motifs (“small refers to nucleic acid motifs no more than 100 nucleotides in length, preferably no more than 80 nucleotides in length, and most preferably no more than 50 nucleotides in length; e.g., antisense oligonucleotides, hammerhead or the hairpin ribozymes) are preferably used for exogenous delivery. The simple structure of these molecules increases the ability of the nucleic acid to invade targeted regions of RNA structure. Exemplary molecules of the instant invention were chemically synthesized, and others can similarly be synthesized. Oligodeoxyribonucleotides were synthesized using standard protocols as described in Caruthers et al., 1992 , Methods in Enzymology  211,3-19, and is incorporated herein by reference. 
     The method of synthesis used for normal RNA including certain enzymatic nucleic acid molecules follows the procedure as described in Usman et al., 1987  J. Am. Chem. Soc ., 109, 7845; Scaringe et al., 1990  Nucleic Acids Res ., 18, 5433; Wincott et al., 1995  Nucleic Acids Res . 23, 2677-2684; and Wincott et al., 1997 , Methods Mol. Bio ., 74, 59, and makes use of common nucleic acid protecting and coupling groups, such as dimethoxytrityl at the 5′-end, and phosphoramidites at the 3′-end. In a non-limiting example, small scale syntheses were conducted on a 394 Applied Biosystems, Inc. synthesizer using a 0.2 μmol scale protocol with a 7.5 min coupling step for alkylsilyl protected nucleotides and a 2.5 min coupling step for 2′-O-methylated nucleotides. Table II outlines the amounts and the contact times of the reagents used in the synthesis cycle. Alternatively, syntheses at the 0.2 μmol scale can be done on a 96-well plate synthesizer, such as the instrument produced by Protogene (Palo Alto, Calif.) with minimal modification to the cycle. A 33-fold excess (60 μL of 0.11 M=6.6 μmol) of 2′-O-methyl phosphoramidite and a 75-fold excess of S-ethyl tetrazole (60 μL of 0.25 M=15 μmol) can be used in each coupling cycle of 2′-O-methyl residues relative to polymer-bound 5′-hydroxyl. A 66-fold excess (120 μL of 0.11 M=13.2 μmol) of alkylsilyl (ribo) protected phosphoramidite and a 150-fold excess of S-ethyl tetrazole (120 μL of 0.25 M=30 μmol) can be used in each coupling cycle of ribo residues relative to polymer-bound 5′-hydroxyl. Average coupling yields on the 394 Applied Biosystems, Inc. synthesizer, determined by calorimetric quantitation of the trityl fractions, were 97.5-99%. Other oligonucleotide, synthesis reagents for the 394 Applied . Biosystems, Inc. synthesizer; detritylation solution was 3% TCA in methylene chloride (ABI); capping was performed with 16% N-methyl imidazole in THF (ABI) and 10% acetic anhydride/10% 2,6-lutidine in THF (ABI); oxidation solution was 16.9 mM I 2 , 49 mM pyridine, 9% water in THF (PERSEPTIVE™). Burdick &amp; Jackson Synthesis Grade acetonitrile was used directly from the reagent bottle. S-Ethyltetrazole solution (0.25 M in acetonitrile) was made up from the solid obtained from American International Chemical, Inc. 
     Deprotection of the RNA was performed using either a two-pot or one-pot protocol. For the two-pot protocol, the polymer-bound trityl-on oligoribonucleotide was transferred to a 4 mL glass screw top vial and suspended in a solution of 40% aq. methylamine (1 mL) at 65° C. for 10 min. After cooling to −20° C., the supernatant was removed from the polymer support. The support was washed three times with 1.0 mL of EtOH:MeCN:H2O/3:1:1, vortexed and the supernatant was then added to the first supernatant. The combined supernatants, containing the oligoribonucleotide, were dried to a white powder. The base deprotected oligoribonucleotide was resuspended in anhydrous TEA/HF/NMP solution (300 μL of a solution of 1.5 mL N-methylpyrrolidinone, 750 μL TEA and 1 mL TEA.3HF to provide a 1.4 M HF concentration) and heated to 65° C. After 1.5 h, the oligomer was quenched with 1.5 M NH 4 HCO 3 . 
     Alternatively, for the one-pot protocol, the polymer-bound trityl-on oligoribonucleotide was transferred to a 4 mL glass screw top vial and suspended in a solution of 33% ethanolic methylamine/DMSO:1/1 (0.8 mL) at 65° C. for 15 min. The vial was brought to r.t. TEA.3HF (0.1 mL) was added and the vial was heated at 65° C. for 15 min. The sample was cooled at −20° C. and then quenched with 1.5 M NH 4 HCO 3 . 
     For purification of the trityl-on oligomers, the quenched NH 4 HCO 3  solution was loaded onto a C-18 containing cartridge that had been prewashed with acetonitrile followed by 50 mM TEAA. After washing the loaded cartridge with water, the RNA was detritylated with 0.5% TFA for 13 min. The cartridge was then washed again with water, salt exchanged with 1 M NaCl and washed with water again. The oligonucleotide was then eluted with 30% acetonitrile. 
     Inactive hammerhead ribozymes or binding attenuated control (BAC) oligonucleotides) were synthesized by substituting a U for G 5  and a U for A 14  (numbering from Hertel, K. J., et al., 1992 , Nucleic Acids Res ., 20, 3252). Similarly, one or more nucleotide substitutions can be introduced in other enzymatic nucleic acid molecules to inactivate the molecule and such molecules can serve as a negative control. 
     The average stepwise coupling yields were &gt;98% (Wincott et al., 1995  Nucleic Acids Res . 23, 2677-2684). Those of ordinary skill in the art will recognize that the scale of synthesis can be adapted to be larger or smaller than the example described above including but not limited to 96-well format, all that is important is the ratio of chemicals used in the reaction. 
     Alternatively, the nucleic acid molecules of the present invention can be synthesized separately and joined together post-synthetically, for example, by ligation (Moore et al., 1992 , Science  256, 9923; Draper et al., International PCT publication No. WO 93/23569; Shabarova et al., 1991 , Nucleic Acids Research  19, 4247; Bellon et al., 1997 , Nucleosides  &amp;  Nucleotides , 16, 951; Bellon et al., 1997  Bioconjugate Chem . 8, 204). 
     Ribozymes of the instant invention are also synthesized from DNA templates using bacteriophage T7 RNA polymerase (Milligan and Uhlenbeck, 1989 , Methods Enzymol . 180, 51). 
     Ribozymes are purified by gel electrophoresis using general methods or are purified by high pressure liquid chromatography (HPLC; see, Wincott et al., supra; the totality of which is hereby incorporated herein by reference) and are resuspended in water. 
     Administration of Ribozymes 
     Sullivan et al., PCT WO 94/02595, describes the general methods for delivery of enzymatic RNA molecules. Ribozymes may be administered to cells by a variety of methods known to those familiar to the art, including, but not restricted to, encapsulation in liposomes, by iontophoresis, or by incorporation into other vehicles, such as hydrogels, cyclodextrins, biodegradable nanocapsules, and bioadhesive microspheres. For some indications, ribozymes may be directly delivered ex vivo to cells or tissues with or without the aforementioned vehicles. Alternatively, the RNA/vehicle combination is locally delivered by direct injection or by use of a catheter, infusion pump or stent. Other routes of delivery include, but are not limited to, intravascular, intramuscular, subcutaneous or joint injection, aerosol inhalation, oral (tablet or pill form), topical, systemic, ocular, intraperitoneal and/or intrathecal delivery. More detailed descriptions of ribozyme delivery and administration are provided in Sullivan et al., supra and Draper et al., PCT WO93/23569 which have been incorporated by reference herein. 
     The molecules of the instant invention can be used as pharmaceutical agents. Pharmaceutical agents prevent, inhibit the occurrence, or treat (alleviate a symptom to some extent, preferably all of the symptoms) of a disease state in a patient. 
     The negatively charged polynucleotides of the invention can be administered (e.g., RNA, DNA or protein) and introduced into a patient by any standard means, with or without stabilizers, buffers, and the like, to form a pharmaceutical composition. When it is desired to use a liposome delivery mechanism, standard protocols for formation of liposomes can be followed. The compositions of the present invention may also be formulated and used as tablets, capsules or elixirs for oral administration, suppositories for rectal administration, sterile solutions, suspensions for injectable administration, and other compositions known in the art. 
     The present invention also includes pharmaceutically acceptable formulations of the compounds described. These formulations include salts of the above compounds, egg., acid addition salts, for example, salts of hydrochloric, hydrobromic; acetic acid, and benzene sulfonic acid. 
     A pharmacological composition or formulation refers to a composition or formulation in a form suitable for administration, e.g., systemic administration, into a cell or patient, preferably a human. Suitable forms, in part, depend upon the use or the route of entry, for example, oral, transdermal, or by injection. Such forms should not prevent the composition or formulation from reaching, a target cell (i e., a cell to which the negatively charged polymer is desired to be delivered to). For example, pharmacological compositions injected into the blood stream should be soluble. Other factors are known in the art, and include considerations, such as toxicity and forms which prevent the composition or formulation from exerting its effect. 
     By “systemic administration” is meant in vivo systemic absorption or accumulation of drugs in the blood stream followed by distribution throughout the entire body. Administration routes which lead to systemic absorption include, without limitations: intravenous, subcutaneous, intraperitoneal, inhalation, oral, intrapulmonary and intramuscular. Each of these administration routes expose the desired negatively charged polymers, e.g., nucleic acids, to an accessible diseased tissue. The rate of entry of a drug into the circulation has been shown to be a function of molecular weight or size. The use of a liposome or other drug carrier comprising the compounds of the instant invention can potentially localize the drug, for example, in certain tissue types, such as the tissues of the reticular endothelial system (RES). A liposome formulation which can facilitate the association of drug with the surface of cells, such as, lymphocytes and macrophages is also useful. This approach may provide enhanced delivery of the drug to target cells by taking advantage of the specificity of macrophage and lymphocyte immune recognition of abnormal cells, such as cancer cells. 
     The invention also features the use of a composition comprising surface-modified liposomes containing poly (ethylene glycol) lipids (PEG-modified, or long-circulating liposomes or stealth liposomes). These formulations offer a method for increasing the accumulation of drugs in target tissues. This class of drug carriers resists opsonization and elimination by the mononuclear phagocytic system (MPS or RES), thereby enabling longer blood circulation times and enhanced tissue exposure for the encapsulated drug (Lasic et al.  Chem. Rev . 1995, 95, 2601-2627; Ishiwata et al.,  Chem. Pharm. Bull . 1995, 43, 1005-1011). Such liposomes have been shown to accumulate selectively in tumors, presumably by extravasation and capture in the neovascularized target tissues (Lasic et al.,  Science  1995, 267, 1275-1276; Oku et al., 1995 , Biochim. Biophys. Acta , 1238, 86-90). All of these references are incorporated by reference herein. The long-circulating liposomes enhance the pharmacokinetics and pharmacodynamics of DNA and RNA, particularly compared to conventional cationic liposomes which are known to accumulate in tissues of the MPS (Liu et al.,  J. Biol. Chem . 1995, 42, 24864-24870; Choi et al., International PCT Publication No. WO 96/10391; Ansell et al., International PCT Publication No. WO 96/10390; Holland et al., International PCT Publication No. WO 96/10392; all of which are incorporated by reference herein). Long-circulating liposomes are also likely to protect drugs from nuclease degradation to a greater extent compared to cationic liposomes, based on their ability to avoid accumulation in metabolically aggressive MPS tissues such as the liver and spleen. 
     The present invention also includes compositions prepared for storage or administration which include a pharmaceutically effective amount of the desired compounds in a pharmaceutically acceptable carrier or diluent. Acceptable carriers or diluents for therapeutic use are well known in the pharmaceutical art, and are described, for example, in  Remington&#39;s Pharmaceutical Sciences , Mack Publishing Co. (A. R. Gennaro edit. 1985) hereby incorporated by reference herein. For example, preservatives, stabilizers, dyes and flavoring agents may be provided. Id. at 1449. These include sodium benzoate, sorbic acid and esters of p-hydroxybenzoic acid. In addition, antioxidants and suspending agents may be used. 
     A pharmaceutically effective dose is that dose required to prevent, inhibit the occurrence, or treat (alleviate a symptom to some extent, preferably all of the symptoms) of a disease state. The pharmaceutically effective dose depends on the type of disease, the composition used, the route of administration, the type of mammal being treated, the physical characteristics of the specific mammal under consideration, concurrent medication, and other factors which those skilled in the medical arts will recognize. Generally, an amount between 0.1 mg/kg and 100 mg/kg body weight/day of active ingredients is administered dependent upon potency of the negatively charged polymer. In a one aspect, the invention provides enzymatic nucleic acid molecules that can be delivered exogenously to specific cells as required. The enzymatic nucleic acid molecules are added directly, or can be complexed with cationic lipids, packaged within liposomes, or otherwise delivered to smooth muscle cells. The RNA or RNA complexes can be locally administered to relevant tissues through the use of a catheter, infusion pump or stent, with or without their incorporation in biopolymers. Using the methods described herein, other enzymatic nucleic acid molecules that cleave target nucleic acid may be derived and used as described above. Specific examples of nucleic acid catalysts of the instant invention are provided below in the Tables and figures. 
     Alternatively, the enzymatic nucleic acid molecules of the instant invention can be expressed within cells from eukaryotic promoters (e.g., Izant and Weintraub, 1985  Science  229, 345; McGarry and Lindquist, 1986  Proc. Natl. Acad. Sci. USA  83, 399; Scanlon et al., 1991 , Proc. Natl. Acad. Sci. USA , 88, 10591-5; Kashani-Sabet et al., 1992  Antisense Res. Dev ., 2, 3-15; Dropulic et al., 1992  J. Virol , 66, 1432-41; Weerasinghe et al., 1991  J. Virol , 65, 5531-4; Ojwang et al., 1992  Proc. Natl. Acad. Sci. USA  89, 10802-6; Chen et al., 1992  Nucleic Acids Res ., 20, 4581-9; Sarver et al., 1990  Science  247, 1222-1225; Thompson et al., 1995  Nucleic Acids Res . 23, 2259; Good et al., 1997 , Gene  Therapy, 4, 45; all of the references are hereby incorporated by reference herein in their totalities). Those skilled in the art realize that any nucleic acid can be expressed in eukaryotic cells from the appropriate DNA/RNA vector. The activity of such nucleic acids can be augmented by their release from the primary transcript by a ribozyme (Draper et al., PCT WO 93/23569, and Sullivan et al., PCT WO 94/02595; Ohkawa et al., 1992  Nucleic Acids Symp. Ser ., 27, 15-6; Taira et al., 1991 , Nucleic Acids Res ., 19, 5125-30; Ventura et al., 1993  Nucleic Acids Res ., 21, 3249-55; Chowrira et al., 1994  J. Biol. Chem . 269, 25856; all of the references are hereby incorporated by reference herein in their totalities). 
     In another aspect of the invention, enzymatic nucleic acid molecules that cleave target molecules are expressed from transcription units (see, for example, Couture et al., 1996 , TIG ., 12, 510) inserted into DNA or RNA vectors. The recombinant vectors are preferably DNA plasmids or viral vectors. Ribozyme expressing viral vectors could be constructed based on, but not limited to, adeno-associated virus, retrovirus, adenovirus, or alphavirus. Preferably, the recombinant vectors capable of expressing the ribozymes are delivered as described above, and persist in target cells. Alternatively, viral vectors may be used that provide for transient expression of ribozymes. Such vectors might be repeatedly administered as necessary. Once expressed, the ribozymes cleave the target mRNA. The active ribozyme contains an enzymatic center or core equivalent to those in the examples, and binding arms able to bind target nucleic acid molecules such that cleavage at the target site occurs. Other sequences may be present which do not interfere with such cleavage. Delivery of ribozyme expressing vectors could be systemic, such as by intravenous or intramuscular administration, by administration to target cells ex-planted from the patient followed by reintroduction into the patient, or by any other means that would allow for introduction into the desired target cell (for a review, see Couture et al., 1996 , TIG ., 12, 510). 
     In one aspect, the invention features, an expression vector comprising a nucleic acid sequence encoding at least one of the nucleic acid catalysts of the instant invention. The nucleic acid sequence encoding the nucleic acid catalyst of the instant invention is operable linked in a manner which allows expression of that nucleic acid molecule. 
     In another aspect the invention features, an expression vector comprising: a transcription initiation region (e.g., eukaryotic pol I, II or III initiation region); b) a transcription termination region (e.g. eukaryotic pol I, II or III termination region); c) a nucleic acid sequence encoding at least one of the nucleic acid catalyst of the instant invention; and wherein said sequence is operably linked to said initiation region and said termination region, in a manner which allows expression and/or delivery of said nucleic acid molecule. The vector may optionally include an open reading frame (ORF) for a protein operably linked on the 5′ side or the 3′ side of the sequence encoding the nucleic acid catalyst of the invention; and/or an intron (intervening sequences). 
     Transcription of the ribozyme sequences are driven from a promoter for eukaryotic RNA polymerase I (pol I), RNA polymerase II (pol II), or RNA polymerase III (pol III). Transcripts from pol II or pol III promoters will be expressed at high levels in all cells; the levels of a given pol II promoter in a given cell type will depend on the, nature of the gene regulatory sequences (enhancers, silencers, etc.) present nearby. Prokaryotic RNA polymerase promoters are also used, providing that the prokaryotic RNA polymerase enzyme is expressed in the appropriate cells (Elroy-Stein and Moss, 1990  Proc. Natl. Acad. Sci. USA , 87, 6743-7; Gao and Huang 1993  Nucleic Acids Res ., 21, 2867-72; Lieber et al., 1993  Methods Enzymol ., 217, 47-66; Zhou et al., 1990  Mol. Cell. Biol ., 10, 4529-37). All of these references are incorporated by reference herein. Several investigators have demonstrated that ribozymes expressed from such promoters can function in mammalian cells (e.g. Kashani-Sabet et al., 1992  Antisense Res. Dev ., 2, 3-15; Ojwang et al., 1992  Proc. Natl. Acad. Sci. USA , 89, 10802-6; Chen et al., 1992  Nucleic Acids Res ., 20, 4581-9; Yu et al., 1993  Proc. Natl. Acad. Sci. USA , 90, 6340-4; L&#39;Huillier et al., 1992  EMBO J . 11, 4411-8; Lisziewicz et al., 1993  Proc. Natl. Acad. Sci. U.S.A ., 90, 8000-4; Thompson et al., 1995  Nucleic Acids Res . 23, 2259; Sullenger &amp; Cech, 1993 , Science , 262, 1566). More specifically, transcription units such as the ones derived from genes encoding U6 small nuclear (snRNA), transfer RNA (tRNA) and adenovirus VA RNA are useful in generating high concentrations of desired RNA molecules such as ribozymes in cells (Thompson et al., supra; Couture and Stinchcomb, 1996, supra; Noonberg et al., 1994 , Nucleic Acid Res ., 22, 2830; Noonberg et al., U.S. Pat. No. 5,624,803; Good et al., 1997 , Gene Ther . 4, 45; Beigelman et al., International PCT Publication No. WO 96/18736; all of these publications are incorporated by reference herein). Examples of transcription units suitable for expression of ribozymes of the instant invention are shown in FIG.  15 . The above ribozyme transcription units can be incorporated into a variety of vectors for introduction into mammalian cells, including but not restricted to, plasmid DNA vectors, viral DNA vectors (such as adenovirus or adeno-associated virus vectors), or viral RNA vectors (such as retroviral or alphavirus vectors) (for a review, see Couture and Stinchcomb, 1996, supra). 
     In yet another aspect the invention features an expression vector comprising a nucleic acid sequence encoding at least one of the catalytic nucleic acid molecules of the invention, in-a manner which allows expression of that nucleic acid molecule. The expression vector comprises in one embodiment; a) a transcription initiation region; b) a transcription termination region; c) a nucleic acid sequence encoding at least one said nucleic acid molecule; and wherein said sequence is operably linked to said initiation region and said termination region, in a manner which allows expression and/or delivery of said nucleic acid molecule. In another preferred embodiment the expression vector comprises: a) a transcription initiation region; b) a transcription termination region; c) an open reading frame; d) a sequence encoding at least one said nucleic acid molecule, wherein said gene is operably linked to the 3′-end of said open reading frame; and wherein said gene is operably linked to said initiation region, said open reading frame and said termination region, in a manner which allows expression and/or delivery of said nucleic acid molecule. In yet another embodiment the expression vector comprises: a) a transcription initiation region; b) a transcription termination region; c) an intron; d) a nucleic acid sequence encoding at least one said nucleic acid molecule; and wherein said sequence is operably linked to said initiation region, said intron and said termination region, in a manner which allows expression and/or delivery of said nucleic acid molecule. In another embodiment, the expression vector comprises: a) a transcription initiation region; b) a transcription termination region; c) an intron; d) an open reading frame; e) a nucleic acid sequence encoding at least one said nucleic acid molecule, wherein said sequence is operably linked to the 3′-end of said open reading frame; and wherein said sequence is operably linked to said initiation region, said intron, said open reading frame and said termination region, in a manner which allows expression and/or delivery of said nucleic acid molecule. 
     By “consists essentially of” is meant that the active ribozyme contains an enzymatic center or core equivalent to those in the examples, and binding arms able to bind target nucleic acid molecules such that cleavage at the target site occurs. Other sequences may be present which do not interfere with such cleavage. 
     EXAMPLES 
     The following are non-limiting examples showing the selection, isolation, synthesis and activity of enzymatic nucleic acids of the instant invention. 
     An extensive array of site-directed mutagenesis studies have been conducted with the hammerhead to probe relationships between nucleotide sequence and catalytic activity. These systematic studies have made clear that most nucleotides in the conserved core of the hammerhead ribozyme (Forster &amp; Symons, 1987 , Cell , 49, 211) cannot be mutated without significant loss of catalytic activity. In contrast, a combinatorial strategy that simultaneously screens a large pool of mutagenized ribozymes for RNAs that retain catalytic activity could be used more efficiently to define immutable sequences and to identify new ribozyme variants (Breaker, 1997, supra). For example, Joseph and Burke (1993 ; J. Biol. Chem ., 268, 24515) have used an in vitro selection approach to rapidly screen for sequence variants of the ‘hairpin’ self-cleaving RNA that show improved catalytic activity. This approach was successful in identifying two mutations in the hairpin ribozyme that together give a 10-fold improvement in catalytic rate. Although similar in vitro selection experiments have been conducted with the hammerhead ribozyme (Nakamaye &amp; Eckstein, 1994, supra; Long &amp; Uhlenbeck, 1994, supra; Ishizaka et al., 1995, supra), none of these efforts have successfully screened full-sized hammerhead ribozymes for all possible combinations of sequence variants that encompass the entire catalytic core. 
     Applicant employed in vitro selection strategy to comprehensively test whether the natural consensus sequence for the core of the hammerhead ribozyme produces maximal catalytic rates, or whether sequence variants of this ribozyme could catalyze endonuclease reaction similar to or better than the hammerhead ribozyme. 
     The procedure reported herein to select for intramolecular AUG cleaving sequences is based on Applicant&#39;s previously reported selection of alternative GUC cleaving hammerhead sequences (Vaish et al., 1997 , Biochemistry  36, 6495; incorporated by reference herein). 
     Example 1 
     In Vitro Selection of Self-cleaving RNAs From a Random Pool 
     An initial pool of dsDNAs containing 22 randomized positions flanked by two constant regions was synthesized. These were transcribed, with transcription being initiated with GTPγS, to produce a pool of potential ribozymes. Self-cleavage of active ribozymes occurs during transcription and the cleavage products can then be separated from intact transcripts by means of a mercury gel (Igloi,  Biochemistry  27, 3842). The recovered cleavage products were then reverse transcribed and amplified by PCR to give a dsDNA pool of selected ribozymes. This selection procedure was repeated for 13 cycles before the dsDNA pool was cloned and sequenced. 
     Oligodeoxyribonucleotides and oligoribonucleotides were chemically synthesized and purified as previously described (Vaish et al., 1997  Biochemistry  36, 6495). Primers used in the selection: 
     Primer 1: 
     5′-TGGTGCAAGCTT AATACGACTCACTATA GGGAGACTGTCTAGATCATGAGGATGCTA-3′(Seq. ID No. 1167); 
     Primer 2: 
     5′-TCTCGGATCCTGCAGATCATNNNNNNNNNNNNNNNNNNNNNNAGGATTAGCATCCTCAT-3′(Seq. ID No. 1168). 
     These two primers were used for the initial Sequenase® reaction, and Primer 2 also functioned as restoration primer for the reintroduction of the lost sequences during cleavage. Reverse transcription (RT)-Primer, 5′-TCTCGGATCCTGCAGATCAT-3′ (Seq. ID No. 1169); and polymerase chain reaction (PCR)-Primer, 5′-TGGTGCAAGCTT AATACGACTCA -3′ (Seq. ID No. 1170), with HindIII (5′-end) and BamHI and PstI (3′-end) sites in boldface; T7 promoter is underlined; ribozyme cleavage triplet in italics; N, randomized nucleotides. RNA selection was performed as described (Vaish et al., 1997  Biochemistry  36, 6495 incorporated by reference herein) with modifications to the initial two cycles of selection. Transcriptions from Pool 0 and Pool 1 were performed on a larger scale (10×500 μl and 1×250 μl, respectively) for 12 h and PCR amplification (Step 5) was omitted in each case. Successive transcriptions were performed at 100 μl volume. Transcription reactions were for decreasing periods of time from 12 h (1 st  cycle) to 1 min (13 th  cycle), where reactions for short periods were quenched by addition of EDTA (75 mM final conc.). All transcriptions were performed with 1 μM DNA. DNA template in the PCR mixture was at least 1×10 −15  M. The minimum concentration of RNA template was 1×10 −8  M for reverse transcription. The concentrations were determined assuming a molar extinction coefficient of 6600. 
     A selection pressure was exerted by progressively reducing the time of transcription from 12 h for the first six cycles, to 6 h for the seventh, 1 h for the eighth, 30 min for the ninth and tenth, 5 min for the eleventh, and 1 min for the twelve and thirteenth cycle. White colonies were randomly selected from pools 7 and 10 and those showing self-cleavage upon transcription were sequenced. There was no homology among the sequences. 
     Cloning and sequencing was performed as described (Vaish et al., 1997 , Biochemistry  36, 6495) except that the dsDNA was digested with HindIII and BamHI. Clones from pools seven and ten were tested for transcript self-cleavage from linearized plasmids. For clones from Pool 13 plasmid DNA was amplified by PCR, using the RT- and PCR-primers, and then transcribed. Rates of intramolecular cleavage of transcripts were determined as described but with 10 u of enzyme per μl. Active clones were sequenced. A transcript of only 50 nucleotides, without the extra sequences for cloning beyond stem III, showed a k in-cis  of 0.32 min −1 . 
     By “randomized region” is meant a region of completely random sequence and/or partially random sequence. By completely random sequence is meant a sequence wherein theoretically there is equal representation of A, T, G and C nucleotides or modified derivatives thereof, at each position in the sequence. By partially random sequence is meant a sequence wherein there is an unequal representation of A, T, G and C nucleotides or modified derivatives thereof, at each position in the sequence. A partially random sequence can therefore have one or more positions of complete randomness and one or more positions with defined nucleotides. 
     Characterization of New Self-cleaving Ribozyme Sequences 
     The intramolecular cleavage rate of the most active sequence of pool 7 was 0.03 min −1  and that of pool 10 was 0.06 min −1  (FIG.  3 ). Seventy clones from pool thirteen were picked and amplified by PCR. Of these, 20 gave full-length DNA and were transcribed; and, of these, 14 showed intramolecular cleavage. These 14 active ribozymes could be divided into two groups: one group contained transcripts with 22 nucleotides in the randomized region and the second group contained a deletion in this region with only 21 nucleotides being present. Several sequences were represented twice such as those of clones 29, 36 and 40. One of the most active sequences, from clone 13/40, with k in-cis  of 0.52 min −1  was chosen for further study. In comparison, under these conditions the intramolecular cleavage of the native hammerhead with a GUC triplet was k in-cis  of 0.56 min −1 , indicating that the cleavage activity of the selected ribozyme, Rz13/40, with an AUG triplet is comparable. In order to acquire some information on the secondary structure of Rz13/40, a limited nuclease digest of the 3′-end-labeled, full-length ribozyme was performed. Rz13/40 was prepared by transcription in such a way that cleavage was minimized. A full length transcript for the intramolecularly cleaving ribozyme was generated by transcription at 12° C. for 8 h (Frank et al., 1996 , RNA , 2, 1179; incorporated by reference herein) and 3′-end labeled with  32 pCp. Limited nuclease digestions with RNase A, RNase T1 and nuclease S1 were performed as Hodson et al., 1994 , Nucleic Acids Res ., 22, 1620; Loria et al., 1996 , RNA , 2,551; both are incorporated by reference herein). Alkaline hydrolysis of labeled RNA was performed in 50 mM NaHCO 3  at 100° C. for 7.5 minutes. 
     Limited digestion with RNase A and T1 and nuclease S1, which indicates single-stranded regions, gave a digestion pattern consistent with Rz13/40 adopting a hammerhead-type structure, which comprised three base-paired helices surrounding a single-stranded core (FIG.  4 ). Since the structure of Rz13/40 resembles the hammerhead structure, the same numbering system has been adopted, with positions 3 and 9 in the core being considered vacant. 
     The data of nuclease digestion corresponded fairly well with the MFOLD structure except for a few discrepancies. MFOLD shows base pairing in the core region between U 7  and G 14 ; G 8  and C 13 ; G L2.1  and U L2.5 ; and U 4  and G 7  although there cleavage at these positions by the nucleases. 
     Ribozyme Engineering 
     Sequence, chemical and structural variants of ribozymes of the present invention can be engineered using the techniques shown above and known in the art to cleave a separate target RNA or DNA in  trans . For example, the size of ribozymes can, be reduced or increased using the techniques known in the art (Zaug et al., 1986 , Nature , 324, 429; Ruffner et al., 1990 , Biochem ., 29, 10695; Beaudry et al., 1990 , Biochem ., 29, 6534; McCall el al., 1992 , Proc. Natl. Acad. Sci., USA ., 89, 5710; Long et al., 1994, Supra; Hendry et al., 1994 , BBA  1219, 405; Benseler et al., 1993 , JACS , 115, 8483; Thompson et al., 1996 , Nucl. Acids Res ., 24, 4401; Michels et al., 1995 , Biochem ., 34, 2965; Been et al., 1992 , Biochem ., 31, 11843; Guo et al., 1995 , EMBO. J ., 14, 368; Pan et al., 1994 , Biochem ., 33, 9561; Cech, 1992 , Curr. Op. Struc. Bio.,  2 ,  605   ; Sugiyama et al., 1996 , FEBS Lett ., 392, 215; Beigelman et al., 1994 , Bioorg. Med. Chem ., 4, 1715; all are incorporated in its totality by reference herein). For example, the stem-loop II domain of the ribozymes may not be essential for catalytic activity and hence could be systematically reduced in size using a variety of methods known in the art, to the extent that the overall catalytic activity of the ribozyme is not significantly decreased. 
     Further rounds of in vitro selection strategies described herein and variations thereof can be readily used by a person skilled in the art to evolve additional nucleic acid catalysts and such new catalysts are within the scope of the instant invention. 
     Example 2 
     Trans-cleaving Ribozymes 
     The self-cleaving ribozymes can be divided into separate ribozyme and substrate domains to create a functional bimolecular complex. This ribozyme presumably interacts with the substrate domain by forming base-paired regions that arc analogous to helices I and II of the hammerhead ribozyme (FIG.  1 ). Likewise, the substrate specificity of ribozymes can presumably be altered by changing the sequences of the substrate-binding arms to complement the sequence of the desired substrate molecule, as was achieved with the ribozyme from clone 40 self-cleaving RNA (FIG.  5 ). The numbering convention used in Example 2 is taken from Vaish et al., 1998  PNAS  95, 2158-2162. 
     To further characterize the selected ribozyme for intermolecular cleavage, Rz13/40 was divided into a catalytic portion and the corresponding substrate strand (FIG.  5 ). The initial ribozyme construct was designed with 5 bp each in stems I and III for annealing to the substrate. Stems of this length were chosen because they had been reported to give reliable kinetic data with the hammerhead. Cleavage kinetics of intramolecularly cleaving ribozymes was performed with chemically synthesized ribozyme and substrate in 50 mM Tris-HCl (pH 8.0), and 10 mM MgCl 2  with 50 to 500 nM ribozyme and 25 nM substrate for single turnover, and 50 to 500 nM substrate with 5 to 25 nM ribozyme for multiple turnover kinetics as described (Hertel et al.,  Biochemistry  33, 3374, 1994). The intermolecular version of Rz13/40 of the present invention gave a very high K M  (1.1 mM) and low k cat  (0.1 min −1 ) under single turnover conditions and was inactive under multiple turnover conditions. As there was no doubt about the intramolecular cleavage of Rz13/40, the lack of catalytic activity under multiple turnover conditions must be associated with the design of the intermolecular version. After analysis of the ribozyme-substrate complex by native gel, it was concluded that formation of the complex was inefficient under the conditions used. 
     A second ribozyme construct was synthesized, where stem III was extended to 10 base-pairs. Native gel analysis confirmed the formation of the ribozyme-substrate complex and the ribozyme cleaved its corresponding substrate efficiently under both single and multiple turnover conditions (Table III). The discrepancy between kcat and kcat′ (0.06 and 0.91 min −1  respectively) is presumably the result of product inhibition, which is a common effect observed with the native hammerhead. The time course of cleavage was followed for about 12 half-lives under single turnover conditions. Reactions were first order up to 60% cleavage within the first minute and reached a total of 80%. First order end points with the conventional hammerhead are commonly 70 to 75%. Steady state cleavage rates were linear for several turnovers. Although the hammerhead and class I ribozymes cleave at different internucleotide linkages (FIG.  1 ), both ribozymes appear to proceed by a similar chemical mechanism. The hammerhead ribozyme is known to produce a 2′,3′-cyclic phosphate at the terminus of the 5′-cleavage product, thereby leaving a 5′-hydroxyl terminus on the 3′-cleavage fragment. 
     The site of substrate cleavage was confirmed as being behind G of the AUG cleavage triplet by comparison of the ribozyme cleavage product, obtained under single turnover conditions for 30 min, with the products of a limited alkaline hydrolysis of the 5′-end-labeled substrate and with a partial RNase T1 digest. Reactions were performed in 10 μl containing RNA, 50 mM Tris (pH 8) and CNPase (Sigma Chemicals) (0.62 u to 0.012 u/μl) and incubation at 45° C. for 1.5 h. Product analysis was on a 20% PAGE where the cyclic phosphate-terminated product runs slightly slower than the ring-opened derivative. In addition, the cleavage products were also shown to be the 2′, 3′-cyclic phosphate and a 5′-hydroxyl by hydrolysis with CNPase and labeling with T4 PNK respectively. Thus Rz13/40 cleaves in a similar manner to the hammerhead. In order to investigate the properties and sequence requirements of the selected ribozyme Rz13/40, mutations were made on the substrate and ribozyme strands. In the native hammerhead, stem II has been shortened to as few as two base-pairs without significant loss in activity. However, the removal of a single base-pair (10.3/11.3) in Rz13/40 resulted in a 1000-fold loss in activity for the cleavage behind an AUG triplet indicating the stem-loop structure has a wider role in catalysis. 
     The effect of mutations around the cleavage site has also been investigated under single and multiple turnover conditions (Table III). Surprisingly, the AUA triplet was also cleaved quite efficiently even though it was not selected for, again yielding a 2′, 3′-cyclic phosphate. Triplets terminating in a uridine or cytidine were either cleaved extremely slowly or not at all. Thus, this ribozyme is purine nucleoside specific. Whether this indicates a necessity for base pairing between U 4  and the nucleotide to be cleaved, as possible with AUG and AUA, is uncertain at present. 
     As the native hammerhead strictly requires a uridine in the middle of the triplet, it was of interest to test whether this was applicable to Rz13/40. Interestingly the triplet AAG was cleaved with a k cat  of 0.57 min −1  under single turnover conditions, multiple turnover conditions showed a k cat  of 0.09 min −1 . It was also tested whether the nucleotide next to the cleavage site was of importance. Cleavage of the triplet AUG followed by U or G was found to be only fractionally slower in single turnover than cleavage of AUG-A (Table III). 
     Inspection of the ribozyme sequences reveals some interesting features. The sequence 5′-GCGCG at positions 11.2 to 14 is present in all ribozymes from pool 10 onwards. This would indicate that this sequence may be an indispensable part for activity just as is the case for the GAA sequence in the conventional hammerhead. 
     Of the two classes of ribozyme isolated in Pool 13, the ribozymes with a deletion in the randomized region.are the more active intramolecular cleavers. These ribozymes appear to have an overall secondary structure which is similar to that of the native hammerhead, but there are significant differences. 
     Obvious differences include the ‘vacancies’ at positions 3 and 9 in the core as well as the altered sequence to positions 12 to 14 of the traditional hammerhead ribozyme (FIG. 1) already mentioned. More subtle differences are associated with stem-loop II. In the hammerhead, a variety of structures are tolerated: the stem can be reduced to two base-pairs, and the loop can be of virtually any size and even contain non-nucleotidic linkers. In the selected ribozymes similar to Rz13/40, less variation in the stem-loop structure is observed. In the active ribozymes of this class, the stem-loop II consists of two G:C base-pairs adjacent to the core which are followed by two A:U base-pairs. The stem loop terminates in a five nucleotide loop, where variations at only positions L2.4 and L2.5 of the hammerhead ribozyme have been detected. The length of the stem appears to have a large effect on catalytic efficiency, since the removal of a single base-pair (10.3/11.3) abolishes activity in vitro. The most active sequences in pool 13 have a fully complementary stem II. One mismatch at 10.2/11.2 as in Rz13/1 approximately halves the activity. It is interesting to note that in Pool 13, the more active ribozymes contain a deletion in the randomized region, which is 21 nucleotides instead of 22. Of these only Rz13/31 and 13/29 show reasonable activity. One can draw a secondary structure for these with a stem II with two mismatches and the extra nucleotide in the core region. 
     Initial experiments to determine cleavage site specificities of ribozymes of the instant invention indicate NR/N as the minimum requirement for ribozyme cleavage, where N represents any nucleotide, R represents any purine nucleotide, and / indicates the site of cleavage. Persons skilled in the art can perform further experiments to determine potential cleavage targets of the ribozymes of the instant invention, such experiments can be performed as described in Ruffner et al., 1990 , Biochem ., 29, 10695, and Joseph et al., 1993 , Genes and Development ., 7, 130-138. 
     The new triplet specificity should be useful for the application of the ribozyme family of the present invention for the inhibition of gene expression in that it expands the targets on a mRNA for cleavage. Although the conventional NUX triplets might be considered sufficient for a wide application, the accessibility of oligodeoxynucleotides to mRNAs is very restricted. Thus the specificity of the new ribozyme for cleavage at purines, apparently independent of the nature of the neighboring nucleotides, should represent a considerable advantage over the native NUX-cleaving ribozyme for this application. 
     Example 3 
     Substrate Specificity Variants 
     An investigation of base pairs at positions 13.1-14.1 of the ribozyme shown in FIG. 9 was undertaken. Six different ribozyme-substrate combinations were synthesized where N 13.1 -N 14.1  was either adenosine 13.1 -urdine 14.1  (RZ 1), uridine 13.1 -adenosine 14.1  (RZ 2), inosine 13.1 -cytidine 14.1  (RZ 3), guanosine 13.1 -cytidine 14.1 , (Rz 4) cytidine 13.1 -guanosine 14.1  (RZ 5), or guanosine 13.1 -guanosine 14.1  (RZ 6). The time course of the cleavage of ribozymes 3-6 in FIG. 9 with non A-U base pairs was determined (FIG.  10 ). As shown in FIG. 10, no significant difference was observed between cleavage rates of ribozyme substrate complexes containing the I 13.1 -C 14.1  or G 13.1 -C 14.1  base pair (0.29 vs. 0.21 min −1 , FIG.  10 ). Under comparable conditions the cleavage rate of the AUG substrate was 0.1min −1  with the 6 bp stem III and 5 bp stem I ribozyme (Vaish et al., 1998  PNAS  95, 2158-2162). 
     Because the A 13.1 -U 14.1  pair can be inverted t U 13.1 -A 14.1  without loss of activity (Example 2 above) it was of interest to study Ribozyme-Substrate complexes containing the C 13.1 -G 14.1  pair (RZ 5). This inverted C 13.1 -G 14.1  arrangement retains significant activity (0.09 min −1 ), and it is only 3-fold less active than the corresponding G-C base pair. The use of a G-G base pair (RZ 6) under the specific conditions used in the example caused a significant reduction in the activity of the ribozyme. The A 13.1 -U 14.1  pair containing ribozyme-substrate complex can cleave a target after an AU 14.1 G triplet; specificity of this ribozyme can be altered to cleave after AG 14.1 G triplets with a G 13.1  to C 13.1  substitution. The AU 14.1 G triplet recognizing ribozyme can therefore be engineered to cleavage after AA 14.1 G (see, Example 2), AC 14.1 G and AG 14.1 G triplets. 
     Since the original AU 14.1 G cleaving ribozymes have nonspecific requirements for the 1.1 nucleotide (i.e. the nucleotide downstream of G15) and since position 15 may be any purine, the experimental evidence for the acceptance of any nucleoside at the 14.1 position indicates NR 15 /N as the minimum requirement for ribozyme cleavage, where N represents any nucleotide, R represents any purine nucleotide, and / indicates the site of cleavage. The optimization of these variant ribozyme constructs by modification of stem-loop structures as is known in the art can provide for species with improved cleavage activity. 
     Example 4 
     Identification of Potential Target Sites in Human K-ras RNA 
     The sequence of human K-ras was screened for accessible sites using a computer folding algorithm selecting for AUR/, YG/M, and UG/U target sites where R in any purine, Y is any pyrimidine, M is A or C, and A, U, C, G are adenosine, uridine, cytidine, and guanosine, respectively. Regions of the RNA that did not form secondary folding structures and included cleavage sites for the ribozymes of the instant invention were identified. The sequences of these cleavage sites are shown in Table II. 
     Example 5 
     Selection of Enzymatic Nucleic Acid Cleavage Sites in Human K-ras RNA 
     To test whether the sites predicted by the computer-based RNA-folding algorithm corresponded to accessible sites in K-ras RNA ninety-six ribozyme sites from Table II were selected for further analysis. Ribozyme target sites were chosen by analyzing sequences of Human K-ras, (accession number: NM — 004985) and prioritizing the sites on the basis of folding. Ribozymes were designed that could bind each target and were individually analyzed by computer folding (Christoffersen et al., 1994  J. Mol. Struc. Theochem , 311, 273; Jaeger et al., 1989 , Proc. Natl. Acad. Sci. USA , 86, 7706) to assess whether the ribozyme sequences fold into the appropriate secondary structure. Those ribozymes with unfavorable intramolecular interactions between the binding arms and the catalytic core were eliminated from consideration. As noted below, varying binding arm lengths can be chosen to optimize activity. Generally, at least 5 bases on each arm are able to bind to, or otherwise interact with, the target RNA. 
     Example 6 
     Chemical Synthesis and Purification of Ribozymes for Efficient Cleavage of K-ras RNA 
     Ribozymes were designed to anneal to various sites in the RNA message. The binding arms are complementary to the target site sequences described above. The ribozymes were chemically synthesized. The method of synthesis used followed the procedure for normal RNA synthesis as described above and in Usman et al., (1987  J. Am. Chem. Soc ., 109, 7845), Scaringe et al., (1990  Nucleic Acids Res ., 18, 5433) and Wincott et al., supra, and made use of common nucleic acid protecting and coupling groups, such as dimethoxytrityl at the 5′-end, and phosphoramidites at the 3′-end. The average stepwise coupling yields were &gt;98%. 
     On instrument dithioate linkage formation via PADS/3-picoline: All processes were performed on an ABI (PE Biosystems) 394 DNA/RNA Synthesizer. Phosphorodithioate containing ribozymes were synthesized using PADS (Phenoxy acetyl disulfide), 3-Picoline, Acetonitrile, 5′-O-DMT-2′-O-TBDMS-Uridine-3′-thiophosphoramidite, and standard synthesis reagents and phosphoramidites. A 0.2 M solution of PADS was prepared in 1:1 acetonitrile:3-picoline. This solution was placed on the instrument and substituted for the normal oxidizing reagent to create the phosphorodithioate triester bond. The thio-amidite (0.1 M in ACN) was coupled for 450 seconds using a standard cycle. At the oxidation step, the PADS solution was delivered for 7.5s at a flow rate of 5 mL/min. and with a 300s wait time after delivery. After completion of the synthesis, the oligo was deprotected and purified in the standard manner (MA/H 2 O, 3HF.TEA, NH 4 HCO 3  quench, T-on solid phase purification). 
     Example 7 
     Ribozyme Cleavage of K-ras RNA Target in Vitro 
     Ribozymes targeted to the human K-ras RNA are designed and synthesized as described above. These ribozymes can be tested for cleavage activity in vitro, for example using the following procedure. The target sequences and the nucleotide location within the K-ras RNA are given in Table II. 
     Cleavage Reactions: Full-length or partially full-length, intemally-labeled target RNA for ribozyme cleavage assay is prepared by in vitro transcription in the presence of [α- 32 p] CTP, passed over a G 50 Sephadex® column by spin chromatography and used as substrate RNA without further purification. Alternately, substrates are 5′- 32 P-end labeled using T4 polynucleotide kinase enzyme. Assays are performed by pre-warming a 2× concentration of purified ribozyme in ribozyme cleavage buffer (50 mM Tris-HCl, pH 7.5 at 37° C., 10 mM MgCl 2 ) and the cleavage reaction was initiated by adding the 2× ribozyme mix to an equal volume of substrate RNA (maximum of 1-5 nM) that was also pre-warmed in cleavage buffer. As an initial screen, assays are carried out for 1 hour at 37° C. using a final concentration of either 40 nM or 1 mM ribozyme, i.e., ribozyme excess. The reaction is quenched by the addition of an equal volume of 95% formamide, 20 mM EDTA, 0.05% bromophenol blue and 0.05% xylene cyanol after which the sample is heated to 95° C. for 2 minutes, quick chilled and loaded onto a denaturing polyacrylamide gel. Substrate RNA and the specific RNA cleavage products generated by ribozyme cleavage are visualized on an autoradiograph of the gel. The percentage of cleavage is determined by Phosphor Imager® quantitation of bands representing the intact substrate and the cleavage products. 
     Example 8 
     Cleavage Reactions for Determining Substrate Specificity of Stabilized Ribozymes (Table IV) 
     Substrates are 5′- 32 P-end labeled using T4 polynucleotide kinase enzyme. Assays are performed by pre-warming a 2× concentration of purified ribozyme in ribozyme cleavage buffer (50 mM Tris-HCl, pH 8.0 at 37° C., 10 mM MgCl 2 ) and the cleavage reaction is initiated by adding the 2× ribozyme mix to an equal volume of substrate RNA (maximum of 1-5 nM) that was also pre-warmed in cleavage buffer. Assays are carried out for 1 hour at 37° C. using a final concentration of 500 nM ribozyme, i.e., ribozyme excess. The reaction is quenched at specific time points by the addition of an equal volume of 95% formamide, 20 mM EDTA, 0.05% bromophenol blue and 0.05% xylene cyanol after which the time points are heated to 95° C. for 1 minute and loaded onto a denaturing polyacrylamide gel. Substrate RNA and the specific RNA cleavage products generated by ribozyme cleavage are visualized by scanning a Phosphor Imager® screen which has been exposed to the assay gel. The percentage of cleavage is determined by Phosphor Imager® quantitation of bands representing the intact substrate and the cleavage products. Table IV lists the substrate specificity rate constants for stabilized G-cleaver Ribozymes. 
     Example 9 
     Ribozyme Stability Assay 
     A mixture of 1.5 μg 5′- 32 P-end labeled ribozyme and 13 μg unlabeled (cold) ribozyme is dried down and resuspended in 20 μL human serum. The suspension is incubated at 37° C. for 24 hours. Aliquots of the reaction are quenched at specific time points by removal into a 2.5-fold excess of 95% formamide, 20 mM EDTA, 0.05% bromophenol blue and 0.05% xylene cyanol on ice. A portion of each time point is counted on a scintillation counter for normalizing counts per lane. The time points are heated to 95° C. for 1 minute and loaded onto a denaturing polyacrylamide gel at 750 k cpm per lane. Intact ribozyme and the specific RNA degradation products generated by exposure to ribonucleases in the serum are visualized by scanning a Phosphor Imager® screen which has been exposed to the assay gel. The percentage of full-length ribozyme at each time point is determined by Phosphor Imager® quantitation of bands representing the intact ribozyme and the degradation products. A non-limiting example of a ribozyme of the instant invention utilizing phosphorothioate and/or phosphorodithioate modifications in a stabilized 2′-O-methyl ribonucleotide background with essential “core ribonucleotides” is shown in FIG.  8 . The incorporation of phosphorothioate and/or phosphorodithioate linkages into the enzymatic nucleic acid of the instant invention results in increased serum stability. Replacement of the 3′-phosphodiester at position 6 with a phosphorothioate or phosphorodithioate linkage (FIG. 8) stabilizes the conserved position 6 ribose moiety, which is prone to nucleolytic cleavage. In a study investigating the serum stability of position 6 modified ribozyme variants which preserve the 2′-hydroxyl function at position 6 (FIG.  8 ), the relative stability of the modifications were ranked as follows: 
      3′-Phosphorodithioate&gt;&gt;3′-Phosphorothioate&gt;&gt;4′-Thioribofuranose&gt;Phosphodiester 
     Example 10 
     Cell Culture Models 
     A selected group of 96 G-cleaver ribozymes targeting K-ras RNA (Table V) were tested in human colorectal cancer cells with a mutated K-ras allele (DLD-1), ovarian cancer cells with a mutated K-ras allele (SKOV3), and human colorectal cancer cells with a mutated K-ras allele (SW680). Cells were plated into four 96 well plates at 15000 cells/well. The 96 ribozymes were split into four groups (on four plates) to be able to include the appropriate controls on each plate. The ribozymes were transfected at 100 nM concentration with 5 μg/ml of GSV and incubated overnight Total RNA was prepared 24 hr after transfection using a Quiagen 96 well Rneasy® kit. An additional DNaseI treatment to remove traces of DNA was introduced. RT reactions were prepared using 4 μl of the RNA eluate with a Clontech RT-kit. Analyses were performed using a Multiplex Taqman® assay(PE ABI Prism® 7700 Sequence Detection System User Bulletin #5, © Copyright 1998, The Perkin-Elmer Corporation) using actin as a control. Results indicate that ribozyme (RPI No. 12819, Table V) reduced K-ras mRNA levels by 50% in DLD-1 cells and SKOV3 cells. 
     Diagnostic Uses 
     Enzymatic nucleic acids of this invention may be used as diagnostic tools to examine genetic drift and mutations within diseased cells or to detect the presence of target RNA in a cell. The close relationship between ribozyme activity and the structure of the target RNA allows the detection of mutations in any region of the molecule which alters the base-pairing and three-dimensional structure of the target RNA. By using multiple ribozymes described in this invention, one may map nucleotide changes which are important to RNA structure and function in vitro, as well as in cells and tissues. Cleavage of target RNAs with ribozymes may be used to inhibit gene expression and define the role (essentially) of specified gene products in the progression of disease. In this manner, other genetic targets may be defined as important mediators of the disease. These experiments will lead to better treatment of the disease progression by affording the possibility of combinational therapies (e.g., multiple ribozymes targeted to different genes, ribozymes coupled with known small molecule inhibitors, or intermittent treatment with combinations of ribozymes and/or other chemical or biological molecules). Other in vitro uses of ribozymes of this invention are well known in the art, and include detection of the presence of mRNAs associated with disease condition. Such RNA is detected by determining the presence of.a cleavage product after treatment with a ribozyme using standard methodology. 
     In a specific example, ribozymes which can cleave only wild-type or mutant forms of the target RNA are used for the assay. The first ribozyme is used to identify wild-type RNA present in the sample and the second ribozyme will be used to identify mutant RNA in the sample. As reaction controls, synthetic substrates of both wild-type and mutant RNA will be cleaved by both ribozymes to demonstrate the relative ribozyme efficiencies in the reactions and the absence of cleavage of the “non-targeted” RNA species. The cleavage products from the synthetic substrates will also serve to generate size markers for the analysis of wild-type and mutant RNAs in the sample population. Thus, each analysis can involve two ribozymes, two substrates and one unknown sample which will be combined into six reactions. The presence of cleavage products will be determined using an RNAse protection assay so that full-length and cleavage fragments of each RNA can be analyzed in one lane of a polyacrylamide gel. It is not absolutely required to quantify the results to gain insight into the expression of mutant RNAs and putative risk of the desired phenotypic changes in target cells. The expression of mRNA whose protein product is implicated in the development of the phenotype is adequate to establish risk. If probes of comparable specific activity are used for both transcripts, then a qualitative comparison of RNA levels will be adequate and will decrease the cost of the initial diagnosis. Higher mutant form to wild-type ratios will be correlated with higher risk whether RNA levels are compared qualitatively or quantitatively. 
     Additional Uses 
     Potential usefulness of sequence-specific enzymatic nucleic acid molecules of the instant invention can have many of the same applications for the study of RNA that DNA restriction endonucleases have for the study of DNA (Nathans et al., 1975  Ann. Rev. Biochem . 44:273). For example, the pattern of restriction fragments could be used to establish sequence relationships between two related RNAs, and large RNAs could be specifically cleaved to fragments of a size more useful for study. The ability to engineer sequence specificity of the ribozyme is ideal for cleavage of RNAs of unknown sequence. 
     All patents and publications mentioned in the specification are indicative of the levels of skill of those skilled in the art to which the invention pertains. All references cited in this disclosure are incorporated by reference to the same extent as if each reference had been incorporated by reference in its entirety individually. 
     One skilled in the art would readily appreciate that the present invention is well adapted to carry out the objects and obtain the ends and advantages mentioned, as well as those inherent therein. The methods and compositions described herein as presently representative of preferred embodiments are exemplary and are not intended as limitations on the scope of the invention. Changes therein and other uses will occur to those skilled in the art, which are encompassed within the spirit of the invention, are defined by the scope of the claims. 
     It will be readily apparent to one skilled in the art that varying substitutions and modifications may be made to the invention disclosed herein without departing from the scope and spirit of the invention. Thus, such additional embodiments are within the scope of the present invention and the following claims. 
     The invention illustratively described herein suitably may be practiced in the absence of any element or elements, limitation or limitations which is not specifically disclosed herein. Thus, for example, in each instance herein any of the terms “comprising”, “consisting essentially of” and “consisting of” may be replaced with either of the other two terms. The terms and expressions which have been employed are used as terms of description and not of limitation, and there is no intention that in the use of such terns and expressions of excluding any equivalents of the features shown and described or portions thereof, but it is recognized that various modifications are possible within the scope of the invention claimed. Thus, it should be understood that although the present invention has been specifically disclosed by preferred embodiments, optional features, modification and variation of the concepts herein disclosed may be resorted to by those skilled in the art, and that such modifications and variations are considered to be within the scope of this invention as defined by the description and the appended claims. 
     In addition, where features or aspects of the invention are described in terms of Markush groups or other grouping of alternatives, those skilled in the art will recognize that the invention is also thereby described in terms of any individual member or subgroup of members of the Markush group or other group. 
     Thus, additional embodiments are within the scope of the invention and within the following claims. 
     
       
         
           
               
               
               
               
               
             
               
                 TABLE I 
               
               
                   
               
               
                   
                   
                   
                   
                 Wait 
               
               
                 Reagent 
                 Equivalents 
                 Amount 
                 Wait Time* 
                 Time* 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
            
               
                 A. 2.5 μmol Synthesis Cycle ABI 394 Instrument 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                   
                 2′-O-methyl 
                 RNA 
               
               
                 Phosphoramidites 
                 6.5 
                 163 μL 
                 2.5 min  
                 7.5 
               
               
                 S-Ethyl Tetrazole 
                 23.8 
                 238 μL 
                 2.5 min  
                 7.5 
               
               
                 Acetic Anhydride 
                 100 
                 233 μL 
                  5 sec 
                  5 sec 
               
               
                 N-Methyl Imidazole 
                 186 
                 233 μL 
                  5 sec 
                  5 sec 
               
               
                 TCA 
                 110.1 
                     2.3 mL 
                 21 sec 
                  21 sec 
               
               
                 Iodine 
                 11.2 
                     1.7 mL 
                 45 sec 
                  45 sec 
               
               
                 Acetonitrile 
                 NA 
                 6.67 mL  
                 NA 
                 NA 
               
            
           
           
               
            
               
                 B. 0.2 μmol Synthesis Cycle ABI 394 Instrument 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                   
                 2′-O-methyl 
                 RNA 
               
               
                 Phosphoramidites 
                 15 
                  31 μL 
                 233 sec 
                 465 sec 
               
               
                 S-Ethyl Tetrazole 
                 38.7 
                  31 μL 
                 233 min 
                 465 sec 
               
               
                 Acetic Anhydride 
                 655 
                 124 μL 
                  5 sec 
                  5 sec 
               
               
                 N-Methyl Imidazole 
                 1245 
                 124 μL 
                  5 sec 
                  5 sec 
               
               
                 TCA 
                 700 
                 732 μL 
                 10 sec 
                  10 sec 
               
               
                 Iodine 
                 20.6 
                 244 μL 
                 15 sec 
                  15 sec 
               
               
                 Acetonitrile 
                 NA 
                 2.64 mL  
                 NA 
                 NA 
               
            
           
           
               
            
               
                 C. 0.2 μmol Synthesis Cycle 96 well Instrument 
               
            
           
           
               
               
               
               
               
            
               
                   
                 2′-O-methyl/ 
                 2′-O-methyl/ 
                   
                   
               
               
                   
                 Ribo 
                 Ribo 
                 2′-O-methyl 
                 Ribo  
               
               
                 Phosphoramidites 
                 33/66 
                  60/120 μL 
                 233 sec  
                 465 sec 
               
               
                 S-Ethyl Tetrazole 
                  75/150 
                  60/120 μL 
                 233 min  
                 465 sec 
               
               
                 Acetic Anhydride 
                 50/50 
                 50/50 μL 
                 10 sec 
                  10 sec 
               
               
                 N-Methyl Imidazole 
                 502/502 
                 50/50 μL 
                 10 sec 
                  10 sec 
               
               
                 TCA 
                 16,000/ 
                 500/500 
                 15 sec 
                  15 sec 
               
               
                   
                 16,000 
                 μL 
               
               
                 Iodine 
                 6.8/6.8 
                 80/80 μL 
                 30 sec 
                  30 sec 
               
               
                 Acetonitrile 
                 NA 
                 850/850 
                 NA 
                 NA 
               
               
                   
                   
                 μL 
               
               
                   
               
               
                 * Wait time does not include contact time during delivery.  
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE II 
               
             
            
               
                   
               
               
                 Human K-ras Ribozyme and Target Sequence 
               
            
           
           
               
               
               
               
               
            
               
                 Nt. 
                   
                 Seq. ID 
                   
                 Seq. ID 
               
               
                 Position 
                 Substrate Sequence 
                 Nos. 
                 Ribozyme Sequence 
                 Nos. 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 16 
                 GGCGGCGGCC G CGGCG 
                 1 
                 CGCCG UGAUGGCAUGCACUAUGCGCG GGCCGCCGCC 
                 528 
               
               
                 57 
                 UGGCGGCGGC G AAGGU 
                 2 
                 ACCUU UGAUGGCAUGCACUAUGCGCG GCCGCCGCCA 
                 529 
               
               
                 94 
                 CCCGGCCCCC G CCAUU 
                 3 
                 AAUGG UGAUGGCAUGCACUAUGCGCG GGGGGCCGGG 
                 530 
               
               
                 113 
                 GACUGGGAGC G AGCGC 
                 4 
                 GCGCU UGAUGGCAUGCACUAUGCGCG GCUCCCAGUC 
                 531 
               
               
                 117 
                 GGGAGCGAGC G CGGCG 
                 5 
                 CGCCG UGAUGGCAUGCACUAUGCGCG GCUCGCUCCC 
                 532 
               
               
                 122 
                 CGAGCGCGGC G CAGGC 
                 6 
                 GCCUG UGAUGGCAUGCACUAUGCGCG GCCGCGCUCG 
                 533 
               
               
                 131 
                 CGCAGGCACU G AAGGC 
                 7 
                 GCCUU UGAUGGCAUGCACUAUGCGCG AGUGCCUGCG 
                 534 
               
               
                 171 
                 GCUCCCAGGU G CGGGA 
                 8 
                 UCCCG UGAUGGCAUGCACUAUGCGCG ACCUGGGAGC 
                 535 
               
               
                 186 
                 AGAGAGGCCU G CUGAA 
                 9 
                 UUCAG UGAUGGCAUGCACUAUGCGCG AGGCCUCUCU 
                 536 
               
               
                 189 
                 GAGGCCUGCU G AAAAU 
                 10 
                 AUUUU UGAUGGCAUGCACUAUGCGCG AGCAGGCCUC 
                 537 
               
               
                 195 
                 UGCUGAAAAU G ACUGA 
                 11 
                 UCAGU UGAUGGCAUGCACUAUGCGCG AUUUUCAGCA 
                 538 
               
               
                 199 
                 GAAAAUGACU G AAUAU 
                 12 
                 AUAUU UGAUGGCAUGCACUAUGCGCG AGUCAUUUUC 
                 539 
               
               
                 203 
                 AUGACUGAAU A UAAAC 
                 13 
                 GUUUA UGAUGGCAUGCACUAUGCGCG AUUCAGUCAU 
                 540 
               
               
                 205 
                 GACUGAAUAU A AACUU 
                 14 
                 AAGUU UGAUGGCAUGCACUAUGCGCG AUAUUCAGUC 
                 541 
               
               
                 211 
                 AUAUAAACUU G UGGUA 
                 15 
                 UACCA UGAUGGCAUGCACUAUGCGCG AAGUUUAUAU 
                 542 
               
               
                 227 
                 GUUGGAGCUU G UGGCG 
                 16 
                 CGCCA UGAUGGCAUGCACUAUGCGCG AAGCUCCAAC 
                 543 
               
               
                 244 
                 AGGCAAGAGU G CCUUG 
                 17 
                 CAAGG UGAUGGCAUGCACUAUGCGCG ACUCUUGCCU 
                 544 
               
               
                 249 
                 AGAGUGCCUU G ACGAU 
                 18 
                 AUCGU UGAUGGCAUGCACUAUGCGCG AAGGCACUCU 
                 545 
               
               
                 252 
                 GUGCCUUGAC G AUACA 
                 19 
                 UGUAU UGAUGGCAUGCACUAUGCGCG GUCAAGGCAC 
                 546 
               
               
                 255 
                 CCUUGACGAU A CAGCU 
                 20 
                 AGCUG UGAUGGCAUGCACUAUGCGCG AUCGUCAAGG 
                 547 
               
               
                 277 
                 GAAUCAUUUU G UGGAC 
                 21 
                 GUCCA UGAUGGCAUGCACUAUGCGCG AAAAUGAUUC 
                 548 
               
               
                 283 
                 UUUUGUGGAC G AAUAU 
                 22 
                 AUAUU UGAUGGCAUGCACUAUGCGCG GUCCACAAAA 
                 549 
               
               
                 287 
                 GUGGACGAAU A UGAUC 
                 23 
                 GAUCA UGAUGGCAUGCACUAUGCGCG AUUCGUCCAC 
                 550 
               
               
                 289 
                 GGACGAAUAU G AUCCA 
                 24 
                 UGGAU UGAUGGCAUGCACUAUGCGCG AUAUUCGUCC 
                 551 
               
               
                 300 
                 AUCCAACAAU A GAGGA 
                 25 
                 UCCUC UGAUGGCAUGCACUAUGCGCG AUUGUUGGAU 
                 552 
               
               
                 331 
                 AGUAGUAAUU G AUGGA 
                 26 
                 UCCAU UGAUGGCAUGCACUAUGCGCG AAUUACUACU 
                 553 
               
               
                 334 
                 AGUAAUUGAU G GAGAA 
                 27 
                 UUCUC UGAUGGCAUGCACUAUGCGCG AUCAAUUACU 
                 554 
               
               
                 344 
                 GGAGAAACCU G UCUCU 
                 28 
                 AGAGA UGAUGGCAUGCACUAUGCGCG AGGUUUCUCC 
                 555 
               
               
                 355 
                 UCUCUUGGAU A UUCUC 
                 29 
                 GAGAA UGAUGGCAUGCACUAUGCGCG AUCCAAGAGA 
                 556 
               
               
                 361 
                 GGAUAUUCUC G ACACA 
                 30 
                 UGUGU UGAUGGCAUGCACUAUGCGCG GAGAAUAUCC 
                 557 
               
               
                 388 
                 GGAGUACAGU G CAAUG 
                 31 
                 CAUUG UGAUGGCAUGCACUAUGCGCG ACUGUACUCC 
                 558 
               
               
                 393 
                 ACAGUGCAAU G AGGGA 
                 32 
                 UCCCU UGAUGGCAUGCACUAUGCGCG AUUGCACUGU 
                 559 
               
               
                 408 
                 ACCAGUACAU G AGGAC 
                 33 
                 GUCCU UGAUGGCAUGCACUAUGCGCG AUGUACUGGU 
                 560 
               
               
                 431 
                 GGCUUUCUUU G UGUAU 
                 34 
                 AUACA UGAUGGCAUGCACUAUGCGCG AAAGAAAGCC 
                 561 
               
               
                 433 
                 CUUUCUUUGU G UAUUU 
                 35 
                 AAAUA UGAUGGCAUGCACUAUGCGCG ACAAAGAAAG 
                 562 
               
               
                 439 
                 UUGUGUAUUU G CCAUA 
                 36 
                 UAUGG UGAUGGCAUGCACUAUGCGCG AAAUACACAA 
                 563 
               
               
                 444 
                 UAUUUGCCAU A AAUAA 
                 37 
                 UUAUU UGAUGGCAUGCACUAUGCGCG AUGGCAAAUA 
                 564 
               
               
                 448 
                 UGCCAUAAAU A AUACU 
                 38 
                 AGUAU UGAUGGCAUGCACUAUGCGCG AUUUAUGGCA 
                 565 
               
               
                 451 
                 CAUAAAUAAU A CUAAA 
                 39 
                 UUUAG UGAUGGCAUGCACUAUGCGCG AUUAUUUAUG 
                 566 
               
               
                 463 
                 UAAAUCAUUU G AAGAU 
                 40 
                 AUCUU UGAUGGCAUGCACUAUGCGCG AAAUGAUUUA 
                 567 
               
               
                 469 
                 AUUUGAAGAU A UUCAC 
                 41 
                 GUGAA UGAUGGCAUGCACUAUGCGCG AUCUUCAAAU 
                 568 
               
               
                 481 
                 UCACCAUUAU A GAGAA 
                 42 
                 UUCUC UGAUGGCAUGCACUAUGCGCG AUAAUGGUGA 
                 569 
               
               
                 511 
                 UAAGGACUCU G AAGAU 
                 43 
                 AUCUU UGAUGGCAUGCACUAUGCGCG AGAGUCCUUA 
                 570 
               
               
                 517 
                 CUCUGAAGAU G UACCU 
                 44 
                 AGGUA UGAUGGCAUGCACUAUGCGCG AUCUUCAGAG 
                 571 
               
               
                 525 
                 AUGUACCUAU G GUCCU 
                 45 
                 AGGAC UGAUGGCAUGCACUAUGCGCG AUAGGUACAU 
                 572 
               
               
                 541 
                 AGUAGGAAAU A AAUGU 
                 46 
                 ACAUU UGAUGGCAUGCACUAUGCGCG AUUUCCUACU 
                 573 
               
               
                 545 
                 GGAAAUAAAU G UGAUU 
                 47 
                 AAUCA UGAUGGCAUGCACUAUGCGCG AUUUAUUUCC 
                 574 
               
               
                 547 
                 AAAUAAAUGU G AUUUG 
                 48 
                 CAAAU UGAUGGCAUGCACUAUGCGCG ACAUUUAUUU 
                 575 
               
               
                 552 
                 AAUGUGAUUU G CCUUC 
                 49 
                 GAAGG UGAUGGCAUGCACUAUGCGCG AAAUCACAUU 
                 576 
               
               
                 604 
                 AAGAAGUUAU G GAAUU 
                 50 
                 AAUUC UGAUGGCAUGCACUAUGCGCG AUAACUUCUU 
                 577 
               
               
                 619 
                 UCCUUUUAUU G AAACA 
                 51 
                 UGUUU UGAUGGCAUGCACUAUGCGCG AAUAAAAGGA 
                 578 
               
               
                 646 
                 AAGACAGGGU G UUGAU 
                 52 
                 AUCAA UGAUGGCAUGCACUAUGCGCG ACCCUGUCUU 
                 579 
               
               
                 649 
                 ACAGGGUGUU G AUGAU 
                 53 
                 AUCAU UGAUGGCAUGCACUAUGCGCG AACACCCUGU 
                 580 
               
               
                 652 
                 GGGUGUUGAU G AUGCC 
                 54 
                 GGCAU UGAUGGCAUGCACUAUGCGCG AUCAACACCC 
                 581 
               
               
                 655 
                 UGUUGAUGAU G CCUUC 
                 55 
                 GAAGG UGAUGGCAUGCACUAUGCGCG AUCAUCAACA 
                 582 
               
               
                 664 
                 UGCCUUCUAU A CAUUA 
                 56 
                 UAAUG UGAUGGCAUGCACUAUGCGCG AUAGAAGGCA 
                 583 
               
               
                 674 
                 ACAUUAGUUC G AGAAA 
                 57 
                 UUUCU UGAUGGCAUGCACUAUGCGCG GAACUAAUGU 
                 584 
               
               
                 683 
                 CGAGAAAUUC G AAAAC 
                 58 
                 GUUUU UGAUGGCAUGCACUAUGCGCG GAAUUUCUCG 
                 585 
               
               
                 691 
                 UCGAAAACAU A AAGAA 
                 59 
                 UUCUU UGAUGGCAUGCACUAUGCGCG AUGUUUUCGA 
                 586 
               
               
                 702 
                 AAGAAAAGAU G AGCAA 
                 60 
                 UUGCU UGAUGGCAUGCACUAUGCGCG AUCUUUUCUU 
                 587 
               
               
                 712 
                 GAGCAAAGAU G GUAAA 
                 61 
                 UUUAC UGAUGGCAUGCACUAUGCGCG AUCUUUGCUC 
                 588 
               
               
                 746 
                 AAGACAAAGU G UGUAA 
                 62 
                 UUACA UGAUGGCAUGCACUAUGCGCG ACUUUGUCUU 
                 589 
               
               
                 748 
                 GACAAAGUGU G UAAUU 
                 63 
                 AAUUA UGAUGGCAUGCACUAUGCGCG ACACUUUGUC 
                 590 
               
               
                 756 
                 GUGUAAUUAU G UAAAU 
                 64 
                 AUUUA UGAUGGCAUGCACUAUGCGCG AUAAUUACAC 
                 591 
               
               
                 762 
                 UUAUGUAAAU A CAAUU 
                 65 
                 AAUUG UGAUGGCAUGCACUAUGCGCG AUUUACAUAA 
                 592 
               
               
                 769 
                 AAUACAAUUU G UACUU 
                 66 
                 AAGUA UGAUGGCAUGCACUAUGCGCG AAAUUGUAUU 
                 593 
               
               
                 789 
                 CUUAAGGCAU A CUAGU 
                 67 
                 ACUAG UGAUGGCAUGCACUAUGCGCG AUGCCUUAAG 
                 594 
               
               
                 811 
                 GGUAAUUUUU G UACAU 
                 68 
                 AUGUA UGAUGGCAUGCACUAUGCGCG AAAAAUUACC 
                 595 
               
               
                 838 
                 AUUAGCAUUU G UUUUA 
                 69 
                 UAAAA UGAUGGCAUGCACUAUGCGCG AAAUGCUAAU 
                 596 
               
               
                 865 
                 UUUUUUUCCU G CUCCA 
                 70 
                 UGGAG UGAUGGCAUGCACUAUGCGCG AGGAAAAAAA 
                 597 
               
               
                 872 
                 CCUGCUCCAU G CAGAC 
                 71 
                 GUCUG UGAUGGCAUGCACUAUGCGCG AUGGAGCAGG 
                 598 
               
               
                 879 
                 CAUGCAGACU G UUAGC 
                 72 
                 GCUAA UGAUGGCAUGCACUAUGCGCG AGUCUGCAUG 
                 599 
               
               
                 898 
                 UACCUUAAAU G CUUAU 
                 73 
                 AUAAG UGAUGGCAUGCACUAUGCGCG AUUUAAGGUA 
                 600 
               
               
                 912 
                 AUUUUAAAAU G ACAGU 
                 74 
                 ACUGU UGAUGGCAUGCACUAUGCGCG AUUUUAAAAU 
                 601 
               
               
                 936 
                 UUUUUUCCUC G AAGUG 
                 75 
                 CACUU UGAUGGCAUGCACUAUGCGCG GAGGAAAAAA 
                 602 
               
               
                 941 
                 UCCUCGAAGU G CCAGU 
                 76 
                 ACUGG UGAUGGCAUGCACUAUGCGCG ACUUCGAGGA 
                 603 
               
               
                 968 
                 UUUGGUUUUU G AACUA 
                 77 
                 UAGUU UGAUGGCAUGCACUAUGCGCG AAAAACCAAA 
                 604 
               
               
                 979 
                 AACUAGCAAU G CCUGU 
                 78 
                 ACAGG UGAUGGCAUGCACUAUGCGCG AUUGCUAGUU 
                 605 
               
               
                 983 
                 AGCAAUGCCU G UGAAA 
                 79 
                 UUUCA UGAUGGCAUGCACUAUGCGCG AGGCAUUGCU 
                 606 
               
               
                 985 
                 CAAUGCCUGU G AAAAA 
                 80 
                 UUUUU UGAUGGCAUGCACUAUGCGCG ACAGGCAUUG 
                 607 
               
               
                 997 
                 AAAAGAAACU G AAUAC 
                 81 
                 GUAUU UGAUGGCAUGCACUAUGCGCG AGUUUCUUUU 
                 608 
               
               
                 1001 
                 GAAACUGAAU A CCUAA 
                 82 
                 UUAGG UGAUGGCAUGCACUAUGCGCG AUUCAGUUUC 
                 609 
               
               
                 1014 
                 UAAGAUUUCU G UCUUG 
                 83 
                 CAAGA UGAUGGCAUGCACUAUGCGCG AGAAAUCUUA 
                 610 
               
               
                 1031 
                 GGUUUUUGGU G CAUGC 
                 84 
                 GCAUG UGAUGGCAUGCACUAUGCGCG ACCAAAAACC 
                 611 
               
               
                 1035 
                 UUUGGUGCAU G CAGUU 
                 85 
                 AACUG UGAUGGCAUGCACUAUGCGCG AUGCACCAAA 
                 612 
               
               
                 1041 
                 GCAUGCAGUU G AUUAC 
                 86 
                 GUAAU UGAUGGCAUGCACUAUGCGCG AACUGCAUGC 
                 613 
               
               
                 1068 
                 CUUACCAAGU G UGAAU 
                 87 
                 AUUCA UGAUGGCAUGCACUAUGCGCG ACUUGGUAAG 
                 614 
               
               
                 1070 
                 UACCAAGUGU G AAUGU 
                 88 
                 ACAUU UGAUGGCAUGCACUAUGCGCG ACACUUGGUA 
                 615 
               
               
                 1074 
                 AAGUGUGAAU G UUGGU 
                 89 
                 ACCAA UGAUGGCAUGCACUAUGCGCG AUUCACACUU 
                 616 
               
               
                 1080 
                 GAAUGUUGGU G UGAAA 
                 90 
                 UUUCA UGAUGGCAUGCACUAUGCGCG ACCAACAUUC 
                 617 
               
               
                 1082 
                 AUGUUGGUGU G AAACA 
                 91 
                 UGUUU UGAUGGCAUGCACUAUGCGCG ACACCAACAU 
                 618 
               
               
                 1095 
                 ACAAAUUAAU G AAGCU 
                 92 
                 AGCUU UGAUGGCAUGCACUAUGCGCG AUUAAUUUGU 
                 619 
               
               
                 1104 
                 UGAAGCUUUU G AAUCA 
                 93 
                 UGAUU UGAUGGCAUGCACUAUGCGCG AAAAGCUUCA 
                 620 
               
               
                 1120 
                 UCCCUAUUCU G UGUUU 
                 94 
                 AAACA UGAUGGCAUGCACUAUGCGCG AGAAUAGGGA 
                 621 
               
               
                 1122 
                 CCUAUUCUGU G UUUUA 
                 95 
                 UAAAA UGAUGGCAUGCACUAUGCGCG ACAGAAUAGG 
                 622 
               
               
                 1139 
                 CUAGUCACAU A AAUGG 
                 96 
                 CCAUU UGAUGGCAUGCACUAUGCGCG AUGUGACUAG 
                 623 
               
               
                 1143 
                 UCACAUAAAU G GAUUA 
                 97 
                 UAAUC UGAUGGCAUGCACUAUGCGCG AUUUAUGUGA 
                 624 
               
               
                 1165 
                 AAUUUCAGUU G AGACC 
                 98 
                 GGUCU UGAUGGCAUGCACUAUGCGCG AACUGAAAUU 
                 625 
               
               
                 1189 
                 GGUUUUUACU G AAACA 
                 99 
                 UGUUU UGAUGGCAUGCACUAUGCGCG AGUAAAAACC 
                 626 
               
               
                 1197 
                 CUGAAACAUU G AGGGA 
                 100 
                 UCCCU UGAUGGCAUGCACUAUGCGCG AAUGUUUCAG 
                 627 
               
               
                 1214 
                 ACAAAUUUAU G GGCUU 
                 101 
                 AAGCC UGAUGGCAUGCACUAUGCGCG AUAAAUUUGU 
                 628 
               
               
                 1223 
                 UGGGCUUCCU G AUGAU 
                 102 
                 AUCAU UGAUGGCAUGCACUAUGCGCG AGGAAGCCCA 
                 629 
               
               
                 1226 
                 GCUUCCUGAU G AUGAU 
                 103 
                 AUCAU UGAUGGCAUGCACUAUGCGCG AUCAGGAAGC 
                 630 
               
               
                 1229 
                 UCCUGAUGAU G AUUCU 
                 104 
                 AGAAU UGAUGGCAUGCACUAUGCGCG AUCAUCAGGA 
                 631 
               
               
                 1247 
                 UAGGCAUCAU G UCCUA 
                 105 
                 UAGGA UGAUGGCAUGCACUAUGCGCG AUGAUGCCUA 
                 632 
               
               
                 1254 
                 CAUGUCCUAU A GUUUG 
                 106 
                 CAAAC UGAUGGCAUGCACUAUGCGCG AUAGGACAUG 
                 633 
               
               
                 1259 
                 CCUAUAGUUU G UCAUC 
                 107 
                 GAUGA UGAUGGCAUGCACUAUGCGCG AAACUAUAGG 
                 634 
               
               
                 1268 
                 UGUCAUCCCU G AUGAA 
                 108 
                 UUCAU UGAUGGCAUGCACUAUGCGCG AGGGAUGACA 
                 635 
               
               
                 1271 
                 CAUCCCUGAU G AAUGU 
                 109 
                 ACAUU UGAUGGCAUGCACUAUGCGCG AUCAGGGAUG 
                 636 
               
               
                 1275 
                 CCUGAUGAAU G UAAAG 
                 110 
                 CUUUA UGAUGGCAUGCACUAUGCGCG AUUCAUCAGG 
                 637 
               
               
                 1288 
                 AAGUUACACU G UUCAC 
                 111 
                 GUGAA UGAUGGCAUGCACUAUGCGCG AGUGUAACUU 
                 638 
               
               
                 1303 
                 CAAAGGUUUU G UCUCC 
                 112 
                 GGAGA UGAUGGCAUGCACUAUGCGCG AAAACCUUUG 
                 639 
               
               
                 1317 
                 CCUUUCCACU G CUAUU 
                 113 
                 AAUAG UGAUGGCAUGCACUAUGCGCG AGUGGAAAGG 
                 640 
               
               
                 1329 
                 UAUUAGUCAU G GUCAC 
                 114 
                 GUGAC UGAUGGCAUGCACUAUGCGCG AUGACUAAUA 
                 641 
               
               
                 1347 
                 UCCCCAAAAU A UUAUA 
                 115 
                 UAUAA UGAUGGCAUGCACUAUGCGCG AUUUUGGGGA 
                 642 
               
               
                 1352 
                 AAAAUAUUAU A UUUUU 
                 116 
                 AAAAA UGAUGGCAUGCACUAUGCGCG AUAAUAUUUU 
                 643 
               
               
                 1363 
                 UUUUUUCUAU A AAAAG 
                 117 
                 CUUUU UGAUGGCAUGCACUAUGCGCG AUAGAAAAAA 
                 644 
               
               
                 1377 
                 AGAAAAAAAU G GAAAA 
                 118 
                 UUUUC UGAUGGCAUGCACUAUGCGCG AUUUUUUUCU 
                 645 
               
               
                 1398 
                 ACAAGGCAAU G GAAAC 
                 119 
                 GUUUC UGAUGGCAUGCACUAUGCGCG AUUGCCUUGU 
                 646 
               
               
                 1410 
                 AAACUAUUAU A AGGCC 
                 120 
                 GGCCU UGAUGGCAUGCACUAUGCGCG AUAAUAGUUU 
                 647 
               
               
                 1436 
                 CACAUUAGAU A AAUUA 
                 121 
                 UAAUU UGAUGGCAUGCACUAUGCGCG AUCUAAUGUG 
                 648 
               
               
                 1446 
                 AAAUUACUAU A AAGAC 
                 122 
                 GUCUU UGAUGGCAUGCACUAUGCGCG AUAGUAAUUU 
                 649 
               
               
                 1459 
                 GACUCCUAAU A GCUUU 
                 123 
                 AAAGC UGAUGGCAUGCACUAUGCGCG AUUAGGAGUC 
                 650 
               
               
                 1470 
                 GCUUUUUCCU G UUAAG 
                 124 
                 CUUAA UGAUGGCAUGCACUAUGCGCG AGGAAAAAGC 
                 651 
               
               
                 1489 
                 GACCCAGUAU G AAUGG 
                 125 
                 CCAUU UGAUGGCAUGCACUAUGCGCG AUACUGGGUC 
                 652 
               
               
                 1493 
                 CAGUAUGAAU G GGAUU 
                 126 
                 AAUCC UGAUGGCAUGCACUAUGCGCG AUUCAUACUG 
                 653 
               
               
                 1504 
                 GGAUUAUUAU A GCAAC 
                 127 
                 GUUGC UGAUGGCAUGCACUAUGCGCG AUAAUAAUCC 
                 654 
               
               
                 1524 
                 UUGGGGCUAU A UUUAC 
                 128 
                 GUAAA UGAUGGCAUGCACUAUGCGCG AUAGCCCCAA 
                 655 
               
               
                 1532 
                 AUAUUUACAU G CUACU 
                 129 
                 AGUAG UGAUGGCAUGCACUAUGCGCG AUGUAAAUAU 
                 656 
               
               
                 1548 
                 AAAUUUUUAU A AUAAU 
                 130 
                 AUUAU UGAUGGCAUGCACUAUGCGCG AUAAAAAUUU 
                 657 
               
               
                 1551 
                 UUUUUAUAAU A AUUGA 
                 131 
                 UCAAU UGAUGGCAUGCACUAUGCGCG AUUAUAAAAA 
                 658 
               
               
                 1555 
                 UAUAAUAAUU G AAAAG 
                 132 
                 CUUUU UGAUGGCAUGCACUAUGCGCG AAUUAUUAUA 
                 659 
               
               
                 1575 
                 UAACAAGUAU A AAAAA 
                 133 
                 UUUUU UGAUGGCAUGCACUAUGCGCG AUACUUGUUA 
                 660 
               
               
                 1589 
                 AAAUUCUCAU A GGAAU 
                 134 
                 AUUCC UGAUGGCAUGCACUAUGCGCG AUGAGAAUUU 
                 661 
               
               
                 1600 
                 GGAAUUAAAU G UAGUC 
                 135 
                 GACUA UGAUGGCAUGCACUAUGCGCG AUUUAAUUCC 
                 662 
               
               
                 1611 
                 UAGUCUCCCU G UGUCA 
                 136 
                 UGACA UGAUGGCAUGCACUAUGCGCG AGGGAGACUA 
                 663 
               
               
                 1613 
                 GUCUCCCUGU G UCAGA 
                 137 
                 UCUGA UGAUGGCAUGCACUAUGCGCG ACAGGGAGAC 
                 664 
               
               
                 1621 
                 GUGUCAGACU G CUCUU 
                 138 
                 AAGAG UGAUGGCAUGCACUAUGCGCG AGUCUGACAC 
                 665 
               
               
                 1631 
                 GCUCUUUCAU A GUAUA 
                 139 
                 UAUAC UGAUGGCAUGCACUAUGCGCG AUGAAAGAGC 
                 666 
               
               
                 1636 
                 UUCAUAGUAU A ACUUU 
                 140 
                 AAAGU UGAUGGCAUGCACUAUGCGCG AUACUAUGAA 
                 667 
               
               
                 1660 
                 UCUUCAACUU G AGUCU 
                 141 
                 AGACU UGAUGGCAUGCACUAUGCGCG AAGUUGAAGA 
                 668 
               
               
                 1668 
                 UUGAGUCUUU G AAGAU 
                 142 
                 AUCUU UGAUGGCAUGCACUAUGCGCG AAAGACUCAA 
                 669 
               
               
                 1674 
                 CUUUGAAGAU A GUUUU 
                 143 
                 AAAAC UGAUGGCAUGCACUAUGCGCG AUCUUCAAAG 
                 670 
               
               
                 1686 
                 UUUUAAUUCU G CUUGU 
                 144 
                 ACAAG UGAUGGCAUGCACUAUGCGCG AGAAUUAAAA 
                 671 
               
               
                 1690 
                 AAUUCUGCUU G UGACA 
                 145 
                 UGUCA UGAUGGCAUGCACUAUGCGCG AAGCAGAAUU 
                 672 
               
               
                 1692 
                 UUCUGCUUGU G ACAUU 
                 146 
                 AAUGU UGAUGGCAUGCACUAUGCGCG ACAAGCAGAA 
                 673 
               
               
                 1721 
                 GGCCAGUUAU A GCUUA 
                 147 
                 UAAGC UGAUGGCAUGCACUAUGCGCG AUAACUGGCC 
                 674 
               
               
                 1733 
                 CUUAUUAGGU G UUGAA 
                 148 
                 UUCAA UGAUGGCAUGCACUAUGCGCG ACCUAAUAAG 
                 675 
               
               
                 1736 
                 AUUAGGUGUU G AAGAG 
                 149 
                 CUCUU UGAUGGCAUGCACUAUGCGCG AACACCUAAU 
                 676 
               
               
                 1751 
                 GACCAAGGUU G CAAGC 
                 150 
                 GCUUG UGAUGGCAUGCACUAUGCGCG AACCUUGGUC 
                 677 
               
               
                 1765 
                 GCCAGGCCCU G UGUGA 
                 151 
                 UCACA UGAUGGCAUGCACUAUGCGCG AGGGCCUGGC 
                 678 
               
               
                 1767 
                 CAGGCCCUGU G UGAAC 
                 152 
                 GUUCA UGAUGGCAUGCACUAUGCGCG ACAGGGCCUG 
                 679 
               
               
                 1769 
                 GGCCCUGUGU G AACCU 
                 153 
                 AGGUU UGAUGGCAUGCACUAUGCGCG ACACAGGGCC 
                 680 
               
               
                 1776 
                 UGUGAACCUU G AGCUU 
                 154 
                 AAGCU UGAUGGCAUGCACUAUGCGCG AAGGUUCACA 
                 681 
               
               
                 1786 
                 GAGCUUUCAU A GAGAG 
                 155 
                 CUCUC UGAUGGCAUGCACUAUGCGCG AUGAAAGCUC 
                 682 
               
               
                 1803 
                 UUCACAGCAU G GACUG 
                 156 
                 CAGUC UGAUGGCAUGCACUAUGCGCG AUGCUGUGAA 
                 683 
               
               
                 1808 
                 AGCAUGGACU G UGUGC 
                 157 
                 GCACA UGAUGGCAUGCACUAUGCGCG AGUCCAUGCU 
                 684 
               
               
                 1810 
                 CAUGGACUGU G UGCCC 
                 158 
                 GGGCA UGAUGGCAUGCACUAUGCGCG ACAGUCCAUG 
                 685 
               
               
                 1812 
                 UGGACUGUGU G CCCCA 
                 159 
                 UGGGG UGAUGGCAUGCACUAUGCGCG ACACAGUCCA 
                 686 
               
               
                 1827 
                 ACGGUCAUCC G AGUGG 
                 160 
                 CCACU UGAUGGCAUGCACUAUGCGCG GGAUGACCGU 
                 687 
               
               
                 1835 
                 CCGAGUGGUU G UACGA 
                 161 
                 UCGUA UGAUGGCAUGCACUAUGCGCG AACCACUCGG 
                 688 
               
               
                 1839 
                 GUGGUUGUAC G AUGCA 
                 162 
                 UGCAU UGAUGGCAUGCACUAUGCGCG GUACAACCAC 
                 689 
               
               
                 1842 
                 GUUGUACGAU G CAUUG 
                 163 
                 CAAUG UGAUGGCAUGCACUAUGCGCG AUCGUACAAC 
                 690 
               
               
                 1861 
                 AGUCAAAAAU G GGGAG 
                 164 
                 CUCCC UGAUGGCAUGCACUAUGCGCG AUUUUUGACU 
                 691 
               
               
                 1886 
                 CAGUUUGGAU A GCUCA 
                 165 
                 UGAGC UGAUGGCAUGCACUAUGCGCG AUCCAAACUG 
                 692 
               
               
                 1899 
                 UCAACAAGAU A CAAUC 
                 166 
                 GAUUG UGAUGGCAUGCACUAUGCGCG AUCUUGUUGA 
                 693 
               
               
                 1912 
                 AUCUCACUCU G UGGUG 
                 167 
                 CACCA UGAUGGCAUGCACUAUGCGCG AGAGUGAGAU 
                 694 
               
               
                 1923 
                 UGGUGGUCCU G CUGAC 
                 168 
                 GUCAG UGAUGGCAUGCACUAUGCGCG AGGACCACCA 
                 695 
               
               
                 1926 
                 UGGUCCUGCU G ACAAA 
                 169 
                 UUUGU UGAUGGCAUGCACUAUGCGCG AGCAGGACCA 
                 696 
               
               
                 1943 
                 CAAGAGCAUU G CUUUU 
                 170 
                 AAAAG UGAUGGCAUGCACUAUGCGCG AAUGCUCUUG 
                 697 
               
               
                 1949 
                 CAUUGCUUUU G UUUCU 
                 171 
                 AGAAA UGAUGGCAUGCACUAUGCGCG AAAAGCAAUG 
                 698 
               
               
                 1993 
                 ACUUUUAAAU A UUAAC 
                 172 
                 GUUAA UGAUGGCAUGCACUAUGCGCG AUUUAAAAGU 
                 699 
               
               
                 2008 
                 CUCAAAAGUU G AGAUU 
                 173 
                 AAUCU UGAUGGCAUGCACUAUGCGCG AACUUUUGAG 
                 700 
               
               
                 2027 
                 GGGUGGUGGU G UGCCA 
                 174 
                 UGGCA UGAUGGCAUGCACUAUGCGCG ACCACCACCC 
                 701 
               
               
                 2029 
                 GUGGUGGUGU G CCAAG 
                 175 
                 CUUGG UGAUGGCAUGCACUAUGCGCG ACACCACCAC 
                 702 
               
               
                 2059 
                 UUUAAACAAU G AAGUG 
                 176 
                 CACUU UGAUGGCAUGCACUAUGCGCG AUUGUUUAAA 
                 703 
               
               
                 2064 
                 ACAAUGAAGU G AAAAA 
                 177 
                 UUUUU UGAUGGCAUGCACUAUGCGCG ACUUCAUUGU 
                 704 
               
               
                 2124 
                 AAUUAACAUU G CAUAA 
                 178 
                 UUAUG UGAUGGCAUGCACUAUGCGCG AAUGUUAAUU 
                 705 
               
               
                 2128 
                 AACAUUGCAU A AACAC 
                 179 
                 GUGUU UGAUGGCAUGCACUAUGCGCG AUGCAAUGUU 
                 706 
               
               
                 2145 
                 UUUCAAGUCU G AUCCA 
                 180 
                 UGGAU UGAUGGCAUGCACUAUGCGCG AGACUUGAAA 
                 707 
               
               
                 2152 
                 UCUGAUCCAU A UUUAA 
                 181 
                 UUAAA UGAUGGCAUGCACUAUGCGCG AUGGAUCAGA 
                 708 
               
               
                 2159 
                 CAUAUUUAAU A AUGCU 
                 182 
                 AGCAU UGAUGGCAUGCACUAUGCGCG AUUAAAUAUG 
                 709 
               
               
                 2162 
                 AUUUAAUAAU G CUUUA 
                 183 
                 UAAAG UGAUGGCAUGCACUAUGCGCG AUUAUUAAAU 
                 710 
               
               
                 2172 
                 GCUUUAAAAU A AAAAU 
                 184 
                 AUUUU UGAUGGCAUGCACUAUGCGCG AUUUUAAAGC 
                 711 
               
               
                 2178 
                 AAAUAAAAAU A AAAAC 
                 185 
                 GUUUU UGAUGGCAUGCACUAUGCGCG AUUUUUAUUU 
                 712 
               
               
                 2193 
                 CAAUCCUUUU G AUAAA 
                 186 
                 UUUAU UGAUGGCAUGCACUAUGCGCG AAAAGGAUUG 
                 713 
               
               
                 2196 
                 UCCUUUUGAU A AAUUU 
                 187 
                 AAAUU UGAUGGCAUGCACUAUGCGCG AUCAAAAGGA 
                 714 
               
               
                 2207 
                 AAUUUAAAAU G UUACU 
                 188 
                 AGUAA UGAUGGCAUGCACUAUGCGCG AUUUUAAAUU 
                 715 
               
               
                 2224 
                 AUUUUAAAAU A AAUGA 
                 189 
                 UCAUU UGAUGGCAUGCACUAUGCGCG AUUUUAAAAU 
                 716 
               
               
                 2228 
                 UAAAAUAAAU G AAGUG 
                 190 
                 CACUU UGAUGGCAUGCACUAUGCGCG AUUUAUUUUA 
                 717 
               
               
                 2233 
                 UAAAUGAAGU G AGAUG 
                 191 
                 CAUCU UGAUGGCAUGCACUAUGCGCG ACUUCAUUUA 
                 718 
               
               
                 2238 
                 GAAGUGAGAU G GCAUG 
                 192 
                 CAUGC UGAUGGCAUGCACUAUGCGCG AUCUCACUUC 
                 719 
               
               
                 2243 
                 GAGAUGGCAU G GUGAG 
                 193 
                 CUCAC UGAUGGCAUGCACUAUGCGCG AUGCCAUCUC 
                 720 
               
               
                 2246 
                 AUGGCAUGGU G AGGUG 
                 194 
                 CACCU UGAUGGCAUGCACUAUGCGCG ACCAUGCCAU 
                 721 
               
               
                 2251 
                 AUGGUGAGGU G AAAGU 
                 195 
                 ACUUU UGAUGGCAUGCACUAUGCGCG ACCUCACCAU 
                 722 
               
               
                 2273 
                 GGACUAGGUU G UUGGU 
                 196 
                 ACCAA UGAUGGCAUGCACUAUGCGCG AACCUAGUCC 
                 723 
               
               
                 2279 
                 GGUUGUUGGU G ACUUA 
                 197 
                 UAAGU UGAUGGCAUGCACUAUGCGCG ACCAACAACC 
                 724 
               
               
                 2295 
                 GGUUCUAGAU A GGUGU 
                 198 
                 ACACC UGAUGGCAUGCACUAUGCGCG AUCUAGAACC 
                 725 
               
               
                 2299 
                 CUAGAUAGGU G UCUUU 
                 199 
                 AAAGA UGAUGGCAUGCACUAUGCGCG ACCUAUCUAG 
                 726 
               
               
                 2314 
                 UUAGGACUCU G AUUUU 
                 200 
                 AAAAU UGAUGGCAUGCACUAUGCGCG AGAGUCCUAA 
                 727 
               
               
                 2320 
                 CUCUGAUUUU G AGGAC 
                 201 
                 GUCCU UGAUGGCAUGCACUAUGCGCG AAAAUCAGAG 
                 728 
               
               
                 2350 
                 AUUUCUUCAU G UUAAA 
                 202 
                 UUUAA UGAUGGCAUGCACUAUGCGCG AUGAAGAAAU 
                 729 
               
               
                 2397 
                 UUUACACUAU G UGAUU 
                 203 
                 AAUCA UGAUGGCAUGCACUAUGCGCG AUAGUGUAAA 
                 730 
               
               
                 2399 
                 UACACUAUGU G AUUUA 
                 204 
                 UAAAU UGAUGGCAUGCACUAUGCGCG ACAUAGUGUA 
                 731 
               
               
                 2406 
                 UGUGAUUUAU A UUCCA 
                 205 
                 UGGAA UGAUGGCAUGCACUAUGCGCG AUAAAUCACA 
                 732 
               
               
                 2419 
                 CCAUUUACAU A AGGAU 
                 206 
                 AUCCU UGAUGGCAUGCACUAUGCGCG AUGUAAAUGG 
                 733 
               
               
                 2425 
                 ACAUAAGGAU A CACUU 
                 207 
                 AAGUG UGAUGGCAUGCACUAUGCGCG AUCCUUAUGU 
                 734 
               
               
                 2435 
                 ACACUUAUUU G UCAAG 
                 208 
                 CUUGA UGAUGGCAUGCACUAUGCGCG AAAUAAGUGU 
                 735 
               
               
                 2454 
                 AGCACAAUCU G UAAAU 
                 209 
                 AUUUA UGAUGGCAUGCACUAUGCGCG AGAUUGUGCU 
                 736 
               
               
                 2471 
                 UUUAACCUAU G UUACA 
                 210 
                 UGUAA UGAUGGCAUGCACUAUGCGCG AUAGGUUAAA 
                 737 
               
               
                 2488 
                 CAUCUUCAGU G CCAGU 
                 211 
                 ACUGG UGAUGGCAUGCACUAUGCGCG ACUGAAGAUG 
                 738 
               
               
                 2507 
                 GGGCAAAAUU G UGCAA 
                 212 
                 UUGCA UGAUGGCAUGCACUAUGCGCG AAUUUUGCCC 
                 739 
               
               
                 2509 
                 GCAAAAUUGU G CAAGA 
                 213 
                 UCUUG UGAUGGCAUGCACUAUGCGCG ACAAUUUUGC 
                 740 
               
               
                 2518 
                 UGCAAGAGGU G AAGUU 
                 214 
                 AACUU UGAUGGCAUGCACUAUGCGCG ACCUCUUGCA 
                 741 
               
               
                 2527 
                 UGAAGUUUAU A UUUGA 
                 215 
                 UCAAA UGAUGGCAUGCACUAUGCGCG AUAAACUUCA 
                 742 
               
               
                 2531 
                 GUUUAUAUUU G AAUAU 
                 216 
                 AUAUU UGAUGGCAUGCACUAUGCGCG AAAUAUAAAC 
                 743 
               
               
                 2535 
                 AUAUUUGAAU A UCCAU 
                 217 
                 AUGGA UGAUGGCAUGCACUAUGCGCG AUUCAAAUAU 
                 744 
               
               
                 2566 
                 CUUCUUCCAU A UUAGU 
                 218 
                 ACUAA UGAUGGCAUGCACUAUGCGCG AUGGAAGAAG 
                 745 
               
               
                 2572 
                 CCAUAUUAGU G UCAUC 
                 219 
                 GAUGA UGAUGGCAUGCACUAUGCGCG ACUAAUAUGG 
                 746 
               
               
                 2580 
                 GUGUCAUCUU G CCUCC 
                 220 
                 GGAGG UGAUGGCAUGCACUAUGCGCG AAGAUGACAC 
                 747 
               
               
                 2599 
                 CCUUCCACAU G CCCCA 
                 221 
                 UGGGG UGAUGGCAUGCACUAUGCGCG AUGUGGAAGG 
                 748 
               
               
                 2606 
                 CAUGCCCCAU G ACUUG 
                 222 
                 CAAGU UGAUGGCAUGCACUAUGCGCG AUGGGGCAUG 
                 749 
               
               
                 2611 
                 CCCAUGACUU G AUGCA 
                 223 
                 UGCAU UGAUGGCAUGCACUAUGCGCG AAGUCAUGGG 
                 750 
               
               
                 2614 
                 AUGACUUGAU G CAGUU 
                 224 
                 AACUG UGAUGGCAUGCACUAUGCGCG AUCAAGUCAU 
                 751 
               
               
                 2625 
                 CAGUUUUAAU A CUUGU 
                 225 
                 ACAAG UGAUGGCAUGCACUAUGCGCG AUUAAAACUG 
                 752 
               
               
                 2629 
                 UUUAAUACUU G UAAUU 
                 226 
                 AAUUA UGAUGGCAUGCACUAUGCGCG AAGUAUUAAA 
                 753 
               
               
                 2646 
                 CCCUAACCAU A AGAUU 
                 227 
                 AAUCU UGAUGGCAUGCACUAUGCGCG AUGGUUAGGG 
                 754 
               
               
                 2656 
                 AAGAUUUACU G CUGCU 
                 228 
                 AGCAG UGAUGGCAUGCACUAUGCGCG AGUAAAUCUU 
                 755 
               
               
                 2659 
                 AUUUACUGCU G CUGUG 
                 229 
                 CACAG UGAUGGCAUGCACUAUGCGCG AGCAGUAAAU 
                 756 
               
               
                 2662 
                 UACUGCUGCU G UGGAU 
                 230 
                 AUCCA UGAUGGCAUGCACUAUGCGCG AGCAGCAGUA 
                 757 
               
               
                 2668 
                 UGCUGUGGAU A UCUCC 
                 231 
                 GGAGA UGAUGGCAUGCACUAUGCGCG AUCCACAGCA 
                 758 
               
               
                 2676 
                 AUAUCUCCAU G AAGUU 
                 232 
                 AACUU UGAUGGCAUGCACUAUGCGCG AUGGAGAUAU 
                 759 
               
               
                 2690 
                 UUUUCCCACU G AGUCA 
                 233 
                 UGACU UGAUGGCAUGCACUAUGCGCG AGUGGGAAAA 
                 760 
               
               
                 2706 
                 CAUCAGAAAU G CCCUA 
                 234 
                 UAGGG UGAUGGCAUGCACUAUGCGCG AUUUCUGAUG 
                 761 
               
               
                 2744 
                 AAGAGAAUCU G ACAGA 
                 235 
                 UCUGU UGAUGGCAUGCACUAUGCGCG AGAUUCUCUU 
                 762 
               
               
                 2751 
                 UCUGACAGAU A CCAUA 
                 236 
                 UAUGG UGAUGGCAUGCACUAUGCGCG AUCUGUCAGA 
                 763 
               
               
                 2756 
                 CAGAUACCAU A AAGGG 
                 237 
                 CCCUU UGAUGGCAUGCACUAUGCGCG AUGGUAUCUG 
                 764 
               
               
                 2766 
                 AAAGGGAUUU G ACCUA 
                 238 
                 UAGGU UGAUGGCAUGCACUAUGCGCG AAAUCCCUUU 
                 765 
               
               
                 2796 
                 GGUGGUGGCU G AUGCU 
                 239 
                 AGCAU UGAUGGCAUGCACUAUGCGCG AGCCACCACC 
                 766 
               
               
                 2799 
                 GGUGGCUGAU G CUUUG 
                 240 
                 CAAAG UGAUGGCAUGCACUAUGCGCG AUCAGCCACC 
                 767 
               
               
                 2804 
                 CUGAUGCUUU G AACAU 
                 241 
                 AUGUU UGAUGGCAUGCACUAUGCGCG AAAGCAUCAG 
                 768 
               
               
                 2816 
                 ACAUCUCUUU G CUGCC 
                 242 
                 GGCAG UGAUGGCAUGCACUAUGCGCG AAAGAGAUGU 
                 769 
               
               
                 2819 
                 UCUCUUUGCU G CCCAA 
                 243 
                 UUGGG UGAUGGCAUGCACUAUGCGCG AGCAAAGAGA 
                 770 
               
               
                 2834 
                 AUCCAUUAGC G ACAGU 
                 244 
                 ACUGU UGAUGGCAUGCACUAUGCGCG GCUAAUGGAU 
                 771 
               
               
                 2861 
                 ACCCUGGUAU G AAUAG 
                 245 
                 CUAUU UGAUGGCAUGCACUAUGCGCG AUACCAGGGU 
                 772 
               
               
                 2865 
                 UGGUAUGAAU A GACAG 
                 246 
                 CUGUC UGAUGGCAUGCACUAUGCGCG AUUCAUACCA 
                 773 
               
               
                 2900 
                 AGAAUUUAAU A AAGAU 
                 247 
                 AUCUU UGAUGGCAUGCACUAUGCGCG AUUAAAUUCU 
                 774 
               
               
                 2906 
                 UAAUAAAGAU A GUGCA 
                 248 
                 UGCAC UGAUGGCAUGCACUAUGCGCG AUCUUUAUUA 
                 775 
               
               
                 2909 
                 UAAAGAUAGU G CAGAA 
                 249 
                 UUCUG UGAUGGCAUGCACUAUGCGCG ACUAUCUUUA 
                 776 
               
               
                 2936 
                 GGUAAUCUAU A ACUAG 
                 250 
                 CUAGU UGAUGGCAUGCACUAUGCGCG AUAGAUUACC 
                 777 
               
               
                 2964 
                 UAACAGUAAU A CAUUC 
                 251 
                 GAAUG UGAUGGCAUGCACUAUGCGCG AUUACUGUUA 
                 778 
               
               
                 2974 
                 ACAUUCCAUU G UUUUA 
                 252 
                 UAAAA UGAUGGCAUGCACUAUGCGCG AAUGGAAUGU 
                 779 
               
               
                 2998 
                 AAAUCUUCAU G CAAUG 
                 253 
                 CAUUG UGAUGGCAUGCACUAUGCGCG AUGAAGAUUU 
                 780 
               
               
                 3003 
                 UUCAUGCAAU G AAAAA 
                 254 
                 UUUUU UGAUGGCAUGCACUAUGCGCG AUUGCAUGAA 
                 781 
               
               
                 3010 
                 AAUGAAAAAU A CUUUA 
                 255 
                 UAAAG UGAUGGCAUGCACUAUGCGCG AUUUUUCAUU 
                 782 
               
               
                 3022 
                 UUUAAUUCAU G AAGCU 
                 256 
                 AGCUU UGAUGGCAUGCACUAUGCGCG AUGAAUUAAA 
                 783 
               
               
                 3046 
                 UUUUUUUGGU G UCAGA 
                 257 
                 UCUGA UGAUGGCAUGCACUAUGCGCG ACCAAAAAAA 
                 784 
               
               
                 3057 
                 UCAGAGUCUC G CUCUU 
                 258 
                 AAGAG UGAUGGCAUGCACUAUGCGCG GAGACUCUGA 
                 785 
               
               
                 3063 
                 UCUCGCUCUU G UCACC 
                 259 
                 GGUGA UGAUGGCAUGCACUAUGCGCG AAGAGCGAGA 
                 786 
               
               
                 3080 
                 AGGCUGGAAU G CAGUG 
                 260 
                 CACUG UGAUGGCAUGCACUAUGCGCG AUUCCAGCCU 
                 787 
               
               
                 3088 
                 AUGCAGUGGC G CCAUC 
                 261 
                 GAUGG UGAUGGCAUGCACUAUGCGCG GCCACUGCAU 
                 788 
               
               
                 3104 
                 UCAGCUCACU G CAACC 
                 262 
                 GGUUG UGAUGGCAUGCACUAUGCGCG AGUGAGCUGA 
                 789 
               
               
                 3132 
                 AGGUUCAAGC G AUUCU 
                 263 
                 AGAAU UGAUGGCAUGCACUAUGCGCG GCUUGAACCU 
                 790 
               
               
                 3141 
                 CGAUUCUCGU G CCUCG 
                 264 
                 CGAGG UGAUGGCAUGCACUAUGCGCG ACGAGAAUCG 
                 791 
               
               
                 3154 
                 UCGGCCUCCU G AGUAG 
                 265 
                 CUACU UGAUGGCAUGCACUAUGCGCG AGGAGGCCGA 
                 792 
               
               
                 3176 
                 UUACAGGCGU G UGCAC 
                 266 
                 GUGCA UGAUGGCAUGCACUAUGCGCG ACGCCUGUAA 
                 793 
               
               
                 3178 
                 ACAGGCGUGU G CACUA 
                 267 
                 UAGUG UGAUGGCAUGCACUAUGCGCG ACACGCCUGU 
                 794 
               
               
                 3200 
                 ACUAAUUUUU G UAUUU 
                 268 
                 AAAUA UGAUGGCAUGCACUAUGCGCG AAAAAUUAGU 
                 795 
               
               
                 3229 
                 GGUUUCACCU G UUGGC 
                 269 
                 GCCAA UGAUGGCAUGCACUAUGCGCG AGGUGAAACC 
                 796 
               
               
                 3247 
                 GGCUGGUCUC G AACUC 
                 270 
                 GAGUU UGAUGGCAUGCACUAUGCGCG GAGACCAGCC 
                 797 
               
               
                 3255 
                 UCGAACUCCU G ACCUC 
                 271 
                 GAGGU UGAUGGCAUGCACUAUGCGCG AGGAGUUCGA 
                 798 
               
               
                 3265 
                 GACCUCAAGU G AUUCA 
                 272 
                 UGAAU UGAUGGCAUGCACUAUGCGCG ACUUGAGGUC 
                 799 
               
               
                 3287 
                 UUGGCCUCAU A AACCU 
                 273 
                 AGGUU UGAUGGCAUGCACUAUGCGCG AUGAGGCCAA 
                 800 
               
               
                 3293 
                 UCAUAAACCU G UUUUG 
                 274 
                 CAAAA UGAUGGCAUGCACUAUGCGCG AGGUUUAUGA 
                 801 
               
               
                 3298 
                 AACCUGUUUU G CAGAA 
                 275 
                 UUCUG UGAUGGCAUGCACUAUGCGCG AAAACAGGUU 
                 802 
               
               
                 3322 
                 UUCAGCAAAU A UUUAU 
                 276 
                 AUAAA UGAUGGCAUGCACUAUGCGCG AUUUGCUGAA 
                 803 
               
               
                 3329 
                 AAUAUUUAUU G AGUGC 
                 277 
                 GCACU UGAUGGCAUGCACUAUGCGCG AAUAAAUAUU 
                 804 
               
               
                 3333 
                 UUUAUUGAGU G CCUAC 
                 278 
                 GUAGG UGAUGGCAUGCACUAUGCGCG ACUCAAUAAA 
                 805 
               
               
                 3344 
                 CCUACCAGAU G CCAGU 
                 279 
                 ACUGG UGAUGGCAUGCACUAUGCGCG AUCUGGUAGG 
                 806 
               
               
                 3354 
                 GCCAGUCACC G CACAA 
                 280 
                 UUGUG UGAUGGCAUGCACUAUGCGCG GGUGACUGGC 
                 807 
               
               
                 3372 
                 CACUGGGUAU A UGGUA 
                 281 
                 UACCA UGAUGGCAUGCACUAUGCGCG AUACCCAGUG 
                 808 
               
               
                 3374 
                 CUGGGUAUAU G GUAUC 
                 282 
                 GAUAC UGAUGGCAUGCACUAUGCGCG AUAUACCCAG 
                 809 
               
               
                 3396 
                 CAAGAGACAU A AUCCC 
                 283 
                 GGGAU UGAUGGCAUGCACUAUGCGCG AUGUCUCUUG 
                 810 
               
               
                 3416 
                 CUUAGGUACU G CUAGU 
                 284 
                 ACUAG UGAUGGCAUGCACUAUGCGCG AGUACCUAAG 
                 811 
               
               
                 3422 
                 UACUGCUAGU G UGGUC 
                 285 
                 GACCA UGAUGGCAUGCACUAUGCGCG ACUAGCAGUA 
                 812 
               
               
                 3429 
                 AGUGUGGUCU G UAAUA 
                 286 
                 UAUUA UGAUGGCAUGCACUAUGCGCG AGACCACACU 
                 813 
               
               
                 3434 
                 GGUCUGUAAU A UCUUA 
                 287 
                 UAAGA UGAUGGCAUGCACUAUGCGCG AUUACAGACC 
                 814 
               
               
                 3456 
                 CCUUUGGUAU A CGACC 
                 288 
                 GGUCG UGAUGGCAUGCACUAUGCGCG AUACCAAAGG 
                 815 
               
               
                 3458 
                 UUUGGUAUAC G ACCCA 
                 289 
                 UGGGU UGAUGGCAUGCACUAUGCGCG GUAUACCAAA 
                 816 
               
               
                 3469 
                 ACCCAGAGAU A ACACG 
                 290 
                 CGUGU UGAUGGCAUGCACUAUGCGCG AUCUCUGGGU 
                 817 
               
               
                 3474 
                 GAGAUAACAC G AUGCG 
                 291 
                 CGCAU UGAUGGCAUGCACUAUGCGCG GUGUUAUCUC 
                 818 
               
               
                 3477 
                 AUAACACGAU G CGUAU 
                 292 
                 AUACG UGAUGGCAUGCACUAUGCGCG AUCGUGUUAU 
                 819 
               
               
                 3492 
                 UUUUAGUUUU G CAAAG 
                 293 
                 CUUUG UGAUGGCAUGCACUAUGCGCG AAAACUAAAA 
                 820 
               
               
                 3514 
                 UUUGGUCUCU G UGCCA 
                 294 
                 UGGCA UGAUGGCAUGCACUAUGCGCG AGAGACCAAA 
                 821 
               
               
                 3516 
                 UGGUCUCUGU G CCAGC 
                 295 
                 GCUGG UGAUGGCAUGCACUAUGCGCG ACAGAGACCA 
                 822 
               
               
                 3527 
                 CCAGCUCUAU A AUUGU 
                 296 
                 ACAAU UGAUGGCAUGCACUAUGCGCG AUAGAGCUGG 
                 823 
               
               
                 3531 
                 CUCUAUAAUU G UUUUG 
                 297 
                 CAAAA UGAUGGCAUGCACUAUGCGCG AAUUAUAGAG 
                 824 
               
               
                 3536 
                 UAAUUGUUUU G CUACG 
                 298 
                 CGUAG UGAUGGCAUGCACUAUGCGCG AAAACAAUUA 
                 825 
               
               
                 3541 
                 GUUUUGCUAC G AUUCC 
                 299 
                 GGAAU UGAUGGCAUGCACUAUGCGCG GUAGCAAAAC 
                 826 
               
               
                 3550 
                 CGAUUCCACU G AAACU 
                 300 
                 AGUUU UGAUGGCAUGCACUAUGCGCG AGUGGAAUCG 
                 827 
               
               
                 3560 
                 GAAACUCUUC G AUCAA 
                 301 
                 UUGAU UGAUGGCAUGCACUAUGCGCG GAAGAGUUUC 
                 828 
               
               
                 3576 
                 GCUACUUUAU G UAAAU 
                 302 
                 AUUUA UGAUGGCAUGCACUAUGCGCG AUAAAGUAGC 
                 829 
               
               
                 3591 
                 UCACUUCAUU G UUUUA 
                 303 
                 UAAAA UGAUGGCAUGCACUAUGCGCG AAUGAAGUGA 
                 830 
               
               
                 3604 
                 UUAAAGGAAU A AACUU 
                 304 
                 AAGUU UGAUGGCAUGCACUAUGCGCG AUUCCUUUAA 
                 831 
               
               
                 3610 
                 GAAUAAACUU G AUUAU 
                 305 
                 AUAAU UGAUGGCAUGCACUAUGCGCG AAGUUUAUUC 
                 832 
               
               
                 3616 
                 ACUUGAUUAU A UUGUU 
                 306 
                 AACAA UGAUGGCAUGCACUAUGCGCG AUAAUCAAGU 
                 833 
               
               
                 3619 
                 UGAUUAUAUU G UUUUU 
                 307 
                 AAAAA UGAUGGCAUGCACUAUGCGCG AAUAUAAUCA 
                 834 
               
               
                 3636 
                 UAUUUGGCAU A ACUGU 
                 308 
                 ACAGU UGAUGGCAUGCACUAUGCGCG AUGCCAAAUA 
                 835 
               
               
                 3640 
                 UGGCAUAACU G UGAUU 
                 309 
                 AAUCA UGAUGGCAUGCACUAUGCGCG AGUUAUGCCA 
                 836 
               
               
                 3642 
                 GCAUAACUGU G AUUCU 
                 310 
                 AGAAU UGAUGGCAUGCACUAUGCGCG ACAGUUAUGC 
                 837 
               
               
                 3663 
                 GACAAUUACU G UACAC 
                 311 
                 GUGUA UGAUGGCAUGCACUAUGCGCG AGUAAUUGUC 
                 838 
               
               
                 3677 
                 ACAUUAAGGU G UAUGU 
                 312 
                 ACAUA UGAUGGCAUGCACUAUGCGCG ACCUUAAUGU 
                 839 
               
               
                 3681 
                 UAAGGUGUAU G UCAGA 
                 313 
                 UCUGA UGAUGGCAUGCACUAUGCGCG AUACACCUUA 
                 840 
               
               
                 3688 
                 UAUGUCAGAU A UUCAU 
                 314 
                 AUGAA UGAUGGCAUGCACUAUGCGCG AUCUGACAUA 
                 841 
               
               
                 3694 
                 AGAUAUUCAU A UUGAC 
                 315 
                 GUCAA UGAUGGCAUGCACUAUGCGCG AUGAAUAUCU 
                 842 
               
               
                 3697 
                 UAUUCAUAUU G ACCCA 
                 316 
                 UGGGU UGAUGGCAUGCACUAUGCGCG AAUAUGAAUA 
                 843 
               
               
                 3706 
                 UGACCCAAAU G UGUAA 
                 317 
                 UUACA UGAUGGCAUGCACUAUGCGCG AUUUGGGUCA 
                 844 
               
               
                 3708 
                 ACCCAAAUGU G UAAUA 
                 318 
                 UAUUA UGAUGGCAUGCACUAUGCGCG ACAUUUGGGU 
                 845 
               
               
                 3713 
                 AAUGUGUAAU A UUCCA 
                 319 
                 UGGAA UGAUGGCAUGCACUAUGCGCG AUUACACAUU 
                 846 
               
               
                 3728 
                 AGUUUUCUCU G CAUAA 
                 320 
                 UUAUG UGAUGGCAUGCACUAUGCGCG AGAGAAAACU 
                 847 
               
               
                 3732 
                 UUCUCUGCAU A AGUAA 
                 321 
                 UUACU UGAUGGCAUGCACUAUGCGCG AUGCAGAGAA 
                 848 
               
               
                 3745 
                 UAAUUAAAAU A UACUU 
                 322 
                 AAGUA UGAUGGCAUGCACUAUGCGCG AUUUUAAUUA 
                 849 
               
               
                 3747 
                 AUUAAAAUAU A CUUAA 
                 323 
                 UUAAG UGAUGGCAUGCACUAUGCGCG AUAUUUUAAU 
                 850 
               
               
                 3761 
                 AAAAAUUAAU A GUUUU 
                 324 
                 AAAAC UGAUGGCAUGCACUAUGCGCG AUUAAUUUUU 
                 851 
               
               
                 3781 
                 GGGUACAAAU A AACAG 
                 325 
                 CUGUU UGAUGGCAUGCACUAUGCGCG AUUUGUACCC 
                 852 
               
               
                 3788 
                 AAUAAACAGU G CCUGA 
                 326 
                 UCAGG UGAUGGCAUGCACUAUGCGCG ACUGUUUAUU 
                 853 
               
               
                 3792 
                 AACAGUGCCU G AACUA 
                 327 
                 UAGUU UGAUGGCAUGCACUAUGCGCG AGGCACUGUU 
                 854 
               
               
                 3823 
                 AAACUUCUAU G UAAAA 
                 328 
                 UUUUA UGAUGGCAUGCACUAUGCGCG AUAGAAGUUU 
                 855 
               
               
                 3837 
                 AAAUCACUAU G AUUUC 
                 329 
                 GAAAU UGAUGGCAUGCACUAUGCGCG AUAGUGAUUU 
                 856 
               
               
                 3844 
                 UAUGAUUUCU G AAUUG 
                 330 
                 CAAUU UGAUGGCAUGCACUAUGCGCG AGAAAUCAUA 
                 857 
               
               
                 3849 
                 UUUCUGAAUU G CUAUG 
                 331 
                 CAUAG UGAUGGCAUGCACUAUGCGCG AAUUCAGAAA 
                 858 
               
               
                 3854 
                 GAAUUGCUAU G UGAAA 
                 332 
                 UUUCA UGAUGGCAUGCACUAUGCGCG AUAGCAAUUC 
                 859 
               
               
                 3856 
                 AUUGCUAUGU G AAACU 
                 333 
                 AGUUU UGAUGGCAUGCACUAUGCGCG ACAUAGCAAU 
                 860 
               
               
                 3880 
                 UUGGAACACU G UUUAG 
                 334 
                 CUAAA UGAUGGCAUGCACUAUGCGCG AGUGUUCCAA 
                 861 
               
               
                 3893 
                 UAGGUAGGGU G UUAAG 
                 335 
                 CUUAA UGAUGGCAUGCACUAUGCGCG ACCCUACCUA 
                 862 
               
               
                 3903 
                 GUUAAGACUU G ACACA 
                 336 
                 UGUGU UGAUGGCAUGCACUAUGCGCG AAGUCUUAAC 
                 863 
               
               
                 3938 
                 AGAAAGAAAU G GCCAU 
                 337 
                 AUGGC UGAUGGCAUGCACUAUGCGCG AUUUCUUUCU 
                 864 
               
               
                 3944 
                 AAAUGGCCAU A CUUCA 
                 338 
                 UGAAG UGAUGGCAUGCACUAUGCGCG AUGGCCAUUU 
                 865 
               
               
                 3956 
                 UUCAGGAACU G CAGUG 
                 339 
                 CACUG UGAUGGCAUGCACUAUGCGCG AGUUCCUGAA 
                 866 
               
               
                 3961 
                 GAACUGCAGU G CUUAU 
                 340 
                 AUAAG UGAUGGCAUGCACUAUGCGCG ACUGCAGUUC 
                 867 
               
               
                 3967 
                 CAGUGCUUAU G AGGGG 
                 341 
                 CCCCU UGAUGGCAUGCACUAUGCGCG AUAAGCACUG 
                 868 
               
               
                 3975 
                 AUGAGGGGAU A UUUAG 
                 342 
                 CUAAA UGAUGGCAUGCACUAUGCGCG AUCCCCUCAU 
                 869 
               
               
                 3988 
                 UAGGCCUCUU G AAUUU 
                 343 
                 AAAUU UGAUGGCAUGCACUAUGCGCG AAGAGGCCUA 
                 870 
               
               
                 3996 
                 UUGAAUUUUU G AUGUA 
                 344 
                 UACAU UGAUGGCAUGCACUAUGCGCG AAAAAUUCAA 
                 871 
               
               
                 3999 
                 AAUUUUUGAU G UAGAU 
                 345 
                 AUCUA UGAUGGCAUGCACUAUGCGCG AUCAAAAAUU 
                 872 
               
               
                 4005 
                 UGAUGUAGAU G GGCAU 
                 346 
                 AUGCC UGAUGGCAUGCACUAUGCGCG AUCUACAUCA 
                 873 
               
               
                 4041 
                 UUACCUUUAU G UGAAC 
                 347 
                 GUUCA UGAUGGCAUGCACUAUGCGCG AUAAAGGUAA 
                 874 
               
               
                 4043 
                 ACCUUUAUGU G AACUU 
                 348 
                 AAGUU UGAUGGCAUGCACUAUGCGCG ACAUAAAGGU 
                 875 
               
               
                 4050 
                 UGUGAACUUU G AAUGG 
                 349 
                 CCAUU UGAUGGCAUGCACUAUGCGCG AAAGUUCACA 
                 876 
               
               
                 4054 
                 AACUUUGAAU G GUUUA 
                 350 
                 UAAAC UGAUGGCAUGCACUAUGCGCG AUUCAAAGUU 
                 877 
               
               
                 4071 
                 CAAAAGAUUU G UUUUU 
                 351 
                 AAAAA UGAUGGCAUGCACUAUGCGCG AAAUCUUUUG 
                 878 
               
               
                 4077 
                 AUUUGUUUUU G UAGAG 
                 352 
                 CUCUA UGAUGGCAUGCACUAUGCGCG AAAAACAAAU 
                 879 
               
               
                 4110 
                 UUCUAGAAAU A AAUGU 
                 353 
                 ACAUU UGAUGGCAUGCACUAUGCGCG AUUUCUAGAA 
                 880 
               
               
                 4114 
                 AGAAAUAAAU G UUACC 
                 354 
                 GGUAA UGAUGGCAUGCACUAUGCGCG AUUUAUUUCU 
                 881 
               
               
                 4152 
                 AAAAAUCCUU G UUGAA 
                 355 
                 UUCAA UGAUGGCAUGCACUAUGCGCG AAGGAUUUUU 
                 882 
               
               
                 4155 
                 AAUCCUUGUU G AAGUU 
                 356 
                 AACUU UGAUGGCAUGCACUAUGCGCG AACAAGGAUU 
                 883 
               
               
                 4186 
                 UAAAUUACAU A GACUU 
                 357 
                 AAGUC UGAUGGCAUGCACUAUGCGCG AUGUAAUUUA 
                 884 
               
               
                 4204 
                 GCAUUAACAU G UUUGU 
                 358 
                 ACAAA UGAUGGCAUGCACUAUGCGCG AUGUUAAUGC 
                 885 
               
               
                 4208 
                 UAACAUGUUU G UGGAA 
                 359 
                 UUCCA UGAUGGCAUGCACUAUGCGCG AAACAUGUUA 
                 886 
               
               
                 4218 
                 GUGGAAGAAU A UAGCA 
                 360 
                 UGCUA UGAUGGCAUGCACUAUGCGCG AUUCUUCCAC 
                 887 
               
               
                 4220 
                 GGAAGAAUAU A GCAGA 
                 361 
                 UCUGC UGAUGGCAUGCACUAUGCGCG AUAUUCUUCC 
                 888 
               
               
                 4231 
                 GCAGACGUAU A UUGUA 
                 362 
                 UACAA UGAUGGCAUGCACUAUGCGCG AUACGUCUGC 
                 889 
               
               
                 4234 
                 GACGUAUAUU G UAUCA 
                 363 
                 UGAUA UGAUGGCAUGCACUAUGCGCG AAUAUACGUC 
                 890 
               
               
                 4243 
                 UGUAUCAUUU G AGUGA 
                 364 
                 UCACU UGAUGGCAUGCACUAUGCGCG AAAUGAUACA 
                 891 
               
               
                 4247 
                 UCAUUUGAGU G AAUGU 
                 365 
                 ACAUU UGAUGGCAUGCACUAUGCGCG ACUCAAAUGA 
                 892 
               
               
                 4251 
                 UUGAGUGAAU G UUCCC 
                 366 
                 GGGAA UGAUGGCAUGCACUAUGCGCG AUUCACUCAA 
                 893 
               
               
                 4285 
                 CUAUUUAACU G AGUCA 
                 367 
                 UGACU UGAUGGCAUGCACUAUGCGCG AGUUAAAUAG 
                 894 
               
               
                 4295 
                 GAGUCACACU G CAUAG 
                 368 
                 CUAUG UGAUGGCAUGCACUAUGCGCG AGUGUGACUC 
                 895 
               
               
                 4299 
                 CACACUGCAU A GGAAU 
                 369 
                 AUUCC UGAUGGCAUGCACUAUGCGCG AUGCAGUGUG 
                 896 
               
               
                 4323 
                 UAACUUUUAU A GGUUA 
                 370 
                 UAACC UGAUGGCAUGCACUAUGCGCG AUAAAAGUUA 
                 897 
               
               
                 4337 
                 UAUCAAAACU G UUGUC 
                 371 
                 GACAA UGAUGGCAUGCACUAUGCGCG AGUUUUGAUA 
                 898 
               
               
                 4340 
                 CAAAACUGUU G UCACC 
                 372 
                 GGUGA UGAUGGCAUGCACUAUGCGCG AACAGUUUUG 
                 899 
               
               
                 4349 
                 UGUCACCAUU G CACAA 
                 373 
                 UUGUG UGAUGGCAUGCACUAUGCGCG AAUGGUGACA 
                 900 
               
               
                 4359 
                 GCACAAUUUU G UCCUA 
                 374 
                 UAGGA UGAUGGCAUGCACUAUGCGCG AAAAUUGUGC 
                 901 
               
               
                 4367 
                 UUGUCCUAAU A UAUAC 
                 375 
                 GUAUA UGAUGGCAUGCACUAUGCGCG AUUAGGACAA 
                 902 
               
               
                 4369 
                 GUCCUAAUAU A UACAU 
                 376 
                 AUGUA UGAUGGCAUGCACUAUGCGCG AUAUUAGGAC 
                 903 
               
               
                 4371 
                 CCUAAUAUAU A CAUAG 
                 377 
                 CUAUG UGAUGGCAUGCACUAUGCGCG AUAUAUUAGG 
                 904 
               
               
                 4375 
                 AUAUAUACAU A GAAAC 
                 378 
                 GUUUC UGAUGGCAUGCACUAUGCGCG AUGUAUAUAU 
                 905 
               
               
                 4384 
                 UAGAAACUUU G UGGGG 
                 379 
                 CCCCA UGAUGGCAUGCACUAUGCGCG AAAGUUUCUA 
                 906 
               
               
                 4393 
                 UGUGGGGCAU G UUAAG 
                 380 
                 CUUAA UGAUGGCAUGCACUAUGCGCG AUGCCCCACA 
                 907 
               
               
                 4408 
                 GUUACAGUUU G CACAA 
                 381 
                 UUGUG UGAUGGCAUGCACUAUGCGCG AAACUGUAAC 
                 908 
               
               
                 4427 
                 CAUCUCAUUU G UAUUC 
                 382 
                 GAAUA UGAUGGCAUGCACUAUGCGCG AAAUGAGAUG 
                 909 
               
               
                 4437 
                 GUAUUCCAUU G AUUUU 
                 383 
                 AAAAU UGAUGGCAUGCACUAUGCGCG AAUGGAAUAC 
                 910 
               
               
                 4480 
                 AAAACAGUAU A UAUAA 
                 384 
                 UUAUA UGAUGGCAUGCACUAUGCGCG AUACUGUUUU 
                 911 
               
               
                 4482 
                 AACAGUAUAU A UAACU 
                 385 
                 AGUUA UGAUGGCAUGCACUAUGCGCG AUAUACUGUU 
                 912 
               
               
                 4484 
                 CAGUAUAUAU A ACUUU 
                 386 
                 AAAGU UGAUGGCAUGCACUAUGCGCG AUAUAUACUG 
                 913 
               
               
                 4527 
                 AAAACUAUCU G AAGAU 
                 387 
                 AUCUU UGAUGGCAUGCACUAUGCGCG AGAUAGUUUU 
                 914 
               
               
                 4541 
                 AUUUCCAUUU G UCAAA 
                 388 
                 UUUGA UGAUGGCAUGCACUAUGCGCG AAAUGGAAAU 
                 915 
               
               
                 4554 
                 AAAAAGUAAU G AUUUC 
                 389 
                 GAAAU UGAUGGCAUGCACUAUGCGCG AUUACUUUUU 
                 916 
               
               
                 4562 
                 AUGAUUUCUU G AUAAU 
                 390 
                 AUUAU UGAUGGCAUGCACUAUGCGCG AAGAAAUCAU 
                 917 
               
               
                 4565 
                 AUUUCUUGAU A AUUGU 
                 391 
                 ACAAU UGAUGGCAUGCACUAUGCGCG AUCAAGAAAU 
                 918 
               
               
                 4569 
                 CUUGAUAAUU G UGUAG 
                 392 
                 CUACA UGAUGGCAUGCACUAUGCGCG AAUUAUCAAG 
                 919 
               
               
                 4571 
                 UGAUAAUUGU G UAGUG 
                 393 
                 CACUA UGAUGGCAUGCACUAUGCGCG ACAAUUAUCA 
                 920 
               
               
                 4576 
                 AUUGUGUAGU G AAUGU 
                 394 
                 ACAUU UGAUGGCAUGCACUAUGCGCG ACUACACAAU 
                 921 
               
               
                 4580 
                 UGUAGUGAAU G UUUUU 
                 395 
                 AAAAA UGAUGGCAUGCACUAUGCGCG AUUCACUACA 
                 922 
               
               
                 4606 
                 CAGUUACCUU G AAAGC 
                 396 
                 GCUUU UGAUGGCAUGCACUAUGCGCG AAGGUAACUG 
                 923 
               
               
                 4613 
                 CUUGAAAGCU G AAUUU 
                 397 
                 AAAUU UGAUGGCAUGCACUAUGCGCG AGCUUUCAAG 
                 924 
               
               
                 4621 
                 CUGAAUUUAU A UUUAG 
                 398 
                 CUAAA UGAUGGCAUGCACUAUGCGCG AUAAAUUCAG 
                 925 
               
               
                 4635 
                 AGUAACUUCU G UGUUA 
                 399 
                 UAACA UGAUGGCAUGCACUAUGCGCG AGAAGUUACU 
                 926 
               
               
                 4637 
                 UAACUUCUGU G UUAAU 
                 400 
                 AUUAA UGAUGGCAUGCACUAUGCGCG ACAGAAGUUA 
                 927 
               
               
                 4643 
                 CUGUGUUAAU A CUGGA 
                 401 
                 UCCAG UGAUGGCAUGCACUAUGCGCG AUUAACACAG 
                 928 
               
               
                 4650 
                 AAUACUGGAU A GCAUG 
                 402 
                 CAUGC UGAUGGCAUGCACUAUGCGCG AUCCAGUAUU 
                 929 
               
               
                 4655 
                 UGGAUAGCAU G AAUUC 
                 403 
                 GAAUU UGAUGGCAUGCACUAUGCGCG AUGCUAUCCA 
                 930 
               
               
                 4662 
                 CAUGAAUUCU G CAUUG 
                 404 
                 CAAUG UGAUGGCAUGCACUAUGCGCG AGAAUUCAUG 
                 931 
               
               
                 4667 
                 AUUCUGCAUU G AGAAA 
                 405 
                 UUUCU UGAUGGCAUGCACUAUGCGCG AAUGCAGAAU 
                 932 
               
               
                 4675 
                 UUGAGAAACU G AAUAG 
                 406 
                 CUAUU UGAUGGCAUGCACUAUGCGCG AGUUUCUCAA 
                 933 
               
               
                 4679 
                 GAAACUGAAU A GCUGU 
                 407 
                 ACAGC UGAUGGCAUGCACUAUGCGCG AUUCAGUUUC 
                 934 
               
               
                 4683 
                 CUGAAUAGCU G UCAUA 
                 408 
                 UAUGA UGAUGGCAUGCACUAUGCGCG AGCUAUUCAG 
                 935 
               
               
                 4688 
                 UAGCUGUCAU A AAAUG 
                 409 
                 CAUUU UGAUGGCAUGCACUAUGCGCG AUGACAGCUA 
                 936 
               
               
                 4693 
                 GUCAUAAAAU G CUUUC 
                 410 
                 GAAAG UGAUGGCAUGCACUAUGCGCG AUUUUAUGAC 
                 937 
               
               
                 4715 
                 AAAGAAAGAU A CUCAC 
                 411 
                 GUGAG UGAUGGCAUGCACUAUGCGCG AUCUUUCUUU 
                 938 
               
               
                 4723 
                 AUACUCACAU G AGUUC 
                 412 
                 GAACU UGAUGGCAUGCACUAUGCGCG AUGUGAGUAU 
                 939 
               
               
                 4731 
                 AUGAGUUCUU G AAGAA 
                 413 
                 UUCUU UGAUGGCAUGCACUAUGCGCG AAGAACUCAU 
                 940 
               
               
                 4738 
                 CUUGAAGAAU A GUCAU 
                 414 
                 AUGAC UGAUGGCAUGCACUAUGCGCG AUUCUUCAAG 
                 941 
               
               
                 4744 
                 GAAUAGUCAU A ACUAG 
                 415 
                 CUAGU UGAUGGCAUGCACUAUGCGCG AUGACUAUUC 
                 942 
               
               
                 4760 
                 AUUAAGAUCU G UGUUU 
                 416 
                 AAACA UGAUGGCAUGCACUAUGCGCG AGAUCUUAAU 
                 943 
               
               
                 4762 
                 UAAGAUCUGU G UUUUA 
                 417 
                 UAAAA UGAUGGCAUGCACUAUGCGCG ACAGAUCUUA 
                 944 
               
               
                 4775 
                 UUAGUUUAAU A GUUUG 
                 418 
                 CAAAC UGAUGGCAUGCACUAUGCGCG AUUAAACUAA 
                 945 
               
               
                 4780 
                 UUAAUAGUUU G AAGUG 
                 419 
                 CACUU UGAUGGCAUGCACUAUGCGCG AAACUAUUAA 
                 946 
               
               
                 4785 
                 AGUUUGAAGU G CCUGU 
                 420 
                 ACAGG UGAUGGCAUGCACUAUGCGCG ACUUCAAACU 
                 947 
               
               
                 4789 
                 UGAAGUGCCU G UUUGG 
                 421 
                 CCAAA UGAUGGCAUGCACUAUGCGCG AGGCACUUCA 
                 948 
               
               
                 4798 
                 UGUUUGGGAU A AUGAU 
                 422 
                 AUCAU UGAUGGCAUGCACUAUGCGCG AUCCCAAACA 
                 949 
               
               
                 4801 
                 UUGGGAUAAU G AUAGG 
                 423 
                 CCUAU UGAUGGCAUGCACUAUGCGCG AUUAUCCCAA 
                 950 
               
               
                 4804 
                 GGAUAAUGAU A GGUAA 
                 424 
                 UUACC UGAUGGCAUGCACUAUGCGCG AUCAUUAUCC 
                 951 
               
               
                 4817 
                 UAAUUUAGAU G AAUUU 
                 425 
                 AAAUU UGAUGGCAUGCACUAUGCGCG AUCUAAAUUA 
                 952 
               
               
                 4843 
                 AAAGUUAUCU G CAGUU 
                 426 
                 AACUG UGAUGGCAUGCACUAUGCGCG AGAUAACUUU 
                 953 
               
               
                 4851 
                 CUGCAGUUAU G UUGAG 
                 427 
                 CUCAA UGAUGGCAUGCACUAUGCGCG AUAACUGCAG 
                 954 
               
               
                 4854 
                 CAGUUAUGUU G AGGGC 
                 428 
                 GCCCU UGAUGGCAUGCACUAUGCGCG AACAUAACUG 
                 955 
               
               
                 4904 
                 GGGUUACAGU G UUUUA 
                 429 
                 UAAAA UGAUGGCAUGCACUAUGCGCG ACUGUAACCC 
                 956 
               
               
                 4913 
                 UGUUUUAUCC G AAAGU 
                 430 
                 ACUUU UGAUGGCAUGCACUAUGCGCG GGAUAAAACA 
                 957 
               
               
                 4932 
                 CAAUUCCACU G UCUUG 
                 431 
                 CAAGA UGAUGGCAUGCACUAUGCGCG AGUGGAAUUG 
                 958 
               
               
                 4937 
                 CCACUGUCUU G UGUUU 
                 432 
                 AAACA UGAUGGCAUGCACUAUGCGCG AAGACAGUGG 
                 959 
               
               
                 4939 
                 ACUGUCUUGU G UUUUC 
                 433 
                 GAAAA UGAUGGCAUGCACUAUGCGCG ACAAGACAGU 
                 960 
               
               
                 4947 
                 GUGUUUUCAU G UUGAA 
                 434 
                 UUCAA UGAUGGCAUGCACUAUGCGCG AUGAAAACAC 
                 961 
               
               
                 4950 
                 UUUUCAUGUU G AAAAU 
                 435 
                 AUUUU UGAUGGCAUGCACUAUGCGCG AACAUGAAAA 
                 962 
               
               
                 4956 
                 UGUUGAAAAU A CUUUU 
                 436 
                 AAAAG UGAUGGCAUGCACUAUGCGCG AUUUUCAACA 
                 963 
               
               
                 4962 
                 AAAUACUUUU G CAUUU 
                 437 
                 AAAUG UGAUGGCAUGCACUAUGCGCG AAAAGUAUUU 
                 964 
               
               
                 4975 
                 UUUUUCCUUU G AGUGC 
                 438 
                 GCACU UGAUGGCAUGCACUAUGCGCG AAAGGAAAAA 
                 965 
               
               
                 4979 
                 UCCUUUGAGU G CCAAU 
                 439 
                 AUUGG UGAUGGCAUGCACUAUGCGCG ACUCAAAGGA 
                 966 
               
               
                 5009 
                 AUUUCUUAAU G UAACA 
                 440 
                 UGUUA UGAUGGCAUGCACUAUGCGCG AUUAAGAAAU 
                 967 
               
               
                 5016 
                 AAUGUAACAU G UUUAC 
                 441 
                 GUAAA UGAUGGCAUGCACUAUGCGCG AUGUUACAUU 
                 968 
               
               
                 5029 
                 UACCUGGCCU G UCUUU 
                 442 
                 AAAGA UGAUGGCAUGCACUAUGCGCG AGGCCAGGUA 
                 969 
               
               
                 5046 
                 AACUAUUUUU G UAUAG 
                 443 
                 CUAUA UGAUGGCAUGCACUAUGCGCG AAAAAUAGUU 
                 970 
               
               
                 5050 
                 AUUUUUGUAU A GUGUA 
                 444 
                 UACAC UGAUGGCAUGCACUAUGCGCG AUACAAAAAU 
                 971 
               
               
                 5053 
                 UUUGUAUAGU G UAAAC 
                 445 
                 GUUUA UGAUGGCAUGCACUAUGCGCG ACUAUACAAA 
                 972 
               
               
                 5060 
                 AGUGUAAACU G AAACA 
                 446 
                 UGUUU UGAUGGCAUGCACUAUGCGCG AGUUUACACU 
                 973 
               
               
                 5067 
                 ACUGAAACAU G CACAU 
                 447 
                 AUGUG UGAUGGCAUGCACUAUGCGCG AUGUUUCAGU 
                 974 
               
               
                 5076 
                 UGCACAUUUU G UACAU 
                 448 
                 AUGUA UGAUGGCAUGCACUAUGCGCG AAAAUGUGCA 
                 975 
               
               
                 5083 
                 UUUGUACAUU G UGCUU 
                 449 
                 AAGCA UGAUGGCAUGCACUAUGCGCG AAUGUACAAA 
                 976 
               
               
                 5085 
                 UGUACAUUGU G CUUUC 
                 450 
                 GAAAG UGAUGGCAUGCACUAUGCGCG ACAAUGUACA 
                 977 
               
               
                 5095 
                 GCUUUCUUUU G UGGGU 
                 451 
                 ACCCA UGAUGGCAUGCACUAUGCGCG AAAAGAAAGC 
                 978 
               
               
                 5104 
                 UGUGGGUCAU A UGCAG 
                 452 
                 CUGCA UGAUGGCAUGCACUAUGCGCG AUGACCCACA 
                 979 
               
               
                 5106 
                 UGGGUCAUAU G CAGUG 
                 453 
                 CACUG UGAUGGCAUGCACUAUGCGCG AUAUGACCCA 
                 980 
               
               
                 5111 
                 CAUAUGCAGU G UGAUC 
                 454 
                 GAUCA UGAUGGCAUGCACUAUGCGCG ACUGCAUAUG 
                 981 
               
               
                 5113 
                 UAUGCAGUGU G AUCCA 
                 455 
                 UGGAU UGAUGGCAUGCACUAUGCGCG ACACUGCAUA 
                 982 
               
               
                 5122 
                 UGAUCCAGUU G UUUUC 
                 456 
                 GAAAA UGAUGGCAUGCACUAUGCGCG AACUGGAUCA 
                 983 
               
               
                 5140 
                 UCAUUUGGUU G CGCUG 
                 457 
                 CAGCG UGAUGGCAUGCACUAUGCGCG AACCAAAUGA 
                 984 
               
               
                 5142 
                 AUUUGGUUGC G CUGAC 
                 458 
                 GUCAG UGAUGGCAUGCACUAUGCGCG GCAACCAAAU 
                 985 
               
               
                 5145 
                 UGGUUGCGCU G ACCUA 
                 459 
                 UAGGU UGAUGGCAUGCACUAUGCGCG AGCGCAACCA 
                 986 
               
               
                 5156 
                 ACCUAGGAAU G UUGGU 
                 460 
                 ACCAA UGAUGGCAUGCACUAUGCGCG AUUCCUAGGU 
                 987 
               
               
                 5165 
                 UGUUGGUCAU A UCAAA 
                 461 
                 UUUGA UGAUGGCAUGCACUAUGCGCG AUGACCAACA 
                 988 
               
               
                 5181 
                 CAUUAAAAAU G ACCAC 
                 462 
                 GUGGU UGAUGGCAUGCACUAUGCGCG AUUUUUAAUG 
                 989 
               
               
                 5196 
                 CUCUUUUAAU G AAAUU 
                 463 
                 AAUUU UGAUGGCAUGCACUAUGCGCG AUUAAAAGAG 
                 990 
               
               
                 5213 
                 ACUUUUAAAU G UUUAU 
                 464 
                 AUAAA UGAUGGCAUGCACUAUGCGCG AUUUAAAAGU 
                 991 
               
               
                 5219 
                 AAAUGUUUAU A GGAGU 
                 465 
                 ACUCC UGAUGGCAUGCACUAUGCGCG AUAAACAUUU 
                 992 
               
               
                 5227 
                 AUAGGAGUAU G UGCUG 
                 466 
                 CAGCA UGAUGGCAUGCACUAUGCGCG AUACUCCUAU 
                 993 
               
               
                 5229 
                 AGGAGUAUGU G CUGUG 
                 467 
                 CACAG UGAUGGCAUGCACUAUGCGCG ACAUACUCCU 
                 994 
               
               
                 5232 
                 AGUAUGUGCU G UGAAG 
                 468 
                 CUUCA UGAUGGCAUGCACUAUGCGCG AGCACAUACU 
                 995 
               
               
                 5234 
                 UAUGUGCUGU G AAGUG 
                 469 
                 CACUU UGAUGGCAUGCACUAUGCGCG ACAGCACAUA 
                 996 
               
               
                 5239 
                 GCUGUGAAGU G AUCUA 
                 470 
                 UAGAU UGAUGGCAUGCACUAUGCGCG ACUUCACAGC 
                 997 
               
               
                 5251 
                 UCUAAAAUUU G UAAUA 
                 471 
                 UAUUA UGAUGGCAUGCACUAUGCGCG AAAUUUUAGA 
                 998 
               
               
                 5256 
                 AAUUUGUAAU A UUUUU 
                 472 
                 AAAAA UGAUGGCAUGCACUAUGCGCG AUUACAAAUU 
                 999 
               
               
                 5262 
                 UAAUAUUUUU G UCAUG 
                 473 
                 CAUGA UGAUGGCAUGCACUAUGCGCG AAAAAUAUUA 
                 1000 
               
               
                 5267 
                 UUUUUGUCAU G AACUG 
                 474 
                 CAGUU UGAUGGCAUGCACUAUGCGCG AUGACAAAAA 
                 1001 
               
               
                 5272 
                 GUCAUGAACU G UACUA 
                 475 
                 UAGUA UGAUGGCAUGCACUAUGCGCG AGUUCAUGAC 
                 1002 
               
               
                 5290 
                 CCUAAUUAUU G UAAUG 
                 476 
                 CAUUA UGAUGGCAUGCACUAUGCGCG AAUAAUUAGG 
                 1003 
               
               
                 5295 
                 UUAUUGUAAU G UAAUA 
                 477 
                 UAUUA UGAUGGCAUGCACUAUGCGCG AUUACAAUAA 
                 1004 
               
               
                 5300 
                 GUAAUGUAAU A AAAAU 
                 478 
                 AUUUU UGAUGGCAUGCACUAUGCGCG AUUACAUUAC 
                 1005 
               
               
                 5306 
                 UAAUAAAAAU A GUUAC 
                 479 
                 GUAAC UGAUGGCAUGCACUAUGCGCG AUUUUUAUUA 
                 1006 
               
               
                 5315 
                 UAGUUACAGU G ACUAU 
                 480 
                 AUAGU UGAUGGCAUGCACUAUGCGCG ACUGUAACUA 
                 1007 
               
               
                 5321 
                 CAGUGACUAU G AGUGU 
                 481 
                 ACACU UGAUGGCAUGCACUAUGCGCG AUAGUCACUG 
                 1008 
               
               
                 5325 
                 GACUAUGAGU G UGUAU 
                 482 
                 AUACA UGAUGGCAUGCACUAUGCGCG ACUCAUAGUC 
                 1009 
               
               
                 5327 
                 CUAUGAGUGU G UAUUU 
                 483 
                 AAAUA UGAUGGCAUGCACUAUGCGCG ACACUCAUAG 
                 1010 
               
               
                 5339 
                 AUUUAUUCAU G CAAAU 
                 484 
                 AUUUG UGAUGGCAUGCACUAUGCGCG AUGAAUAAAU 
                 1011 
               
               
                 5347 
                 AUGCAAAUUU G AACUG 
                 485 
                 CAGUU UGAUGGCAUGCACUAUGCGCG AAAUUUGCAU 
                 1012 
               
               
                 5352 
                 AAUUUGAACU G UUUGC 
                 486 
                 GCAAA UGAUGGCAUGCACUAUGCGCG AGUUCAAAUU 
                 1013 
               
               
                 5356 
                 UGAACUGUUU G CCCCG 
                 487 
                 CGGGG UGAUGGCAUGCACUAUGCGCG AAACAGUUCA 
                 1014 
               
               
                 5361 
                 UGUUUGCCCC G AAAUG 
                 488 
                 CAUUU UGAUGGCAUGCACUAUGCQCG GGGGCAAACA 
                 1015 
               
               
                 5366 
                 GCCCCGAAAU G GAUAU 
                 489 
                 AUAUC UGAUGGCAUGCACUAUGCGCG AUUUCGGGGC 
                 1016 
               
               
                 5370 
                 CGAAAUGGAU A UGGAU 
                 490 
                 AUCCA UGAUGGCAUGCACUAUGCGCG AUCCAUUUCG 
                 1017 
               
               
                 5372 
                 AAAUGGAUAU G GAUAC 
                 491 
                 GUAUC UGAUGGCAUGCACUAUGCGCG AUAUCCAUUU 
                 1018 
               
               
                 5376 
                 GGAUAUGGAU A CUUUA 
                 492 
                 UAAAG UGAUGGCAUGCACUAUGCGCG AUCCAUAUCC 
                 1019 
               
               
                 5383 
                 GAUACUUUAU A AGCCA 
                 493 
                 UGGCU UGAUGGCAUGCACUAUGCGCG AUAAAGUAUC 
                 1020 
               
               
                 5390 
                 UAUAAGCCAU A GACAC 
                 494 
                 GUGUC UGAUGGCAUGCACUAUGCGCG AUGGCUUAUA 
                 1021 
               
               
                 5399 
                 UAGACACUAU A GUAUA 
                 495 
                 UAUAC UGAUGGCAUGCACUAUGCGCG AUAGUGUCUA 
                 1022 
               
               
                 5404 
                 ACUAUAGUAU A CCAGU 
                 496 
                 ACUGG UGAUGGCAUGCACUAUGCGCG AUACUAUAGU 
                 1023 
               
               
                 5410 
                 GUAUACCAGU G AAUCU 
                 497 
                 AGAUU UGAUGGCAUGCACUAUGCGCG ACUGGUAUAC 
                 1024 
               
               
                 5421 
                 AAUCUUUUAU G CAGCU 
                 498 
                 AGCUG UGAUGGCAUGCACUAUGCGCG AUAAAAGAUU 
                 1025 
               
               
                 5428 
                 UAUGCAGCUU G UUAGA 
                 499 
                 UCUAA UGAUGGCAUGCACUAUGCGCG AAGCUGCAUA 
                 1026 
               
               
                 5459 
                 UCUAAAAGGU G CUGUG 
                 500 
                 CACAG UGAUGGCAUGCACUAUGCGCG ACCUUUUAGA 
                 1027 
               
               
                 5462 
                 AAAAGGUGCU G UGGAU 
                 501 
                 AUCCA UGAUGGCAUGCACUAUGCGCG AGCACCUUUU 
                 1028 
               
               
                 5468 
                 UGCUGUGGAU A UUAUG 
                 502 
                 CAUAA UGAUGGCAUGCACUAUGCGCG AUCCACAGCA 
                 1029 
               
               
                 5473 
                 UGGAUAUUAU G UAAAG 
                 503 
                 CUUUA UGAUGGCAUGCACUAUGCGCG AUAAUAUCCA 
                 1030 
               
               
                 5483 
                 GUAAAGGCGU G UUUGC 
                 504 
                 GCAAA UGAUGGCAUGCACUAUGCGCG ACGCCUUUAC 
                 1031 
               
               
                 5487 
                 AGGCGUGUUU G CUUAA 
                 505 
                 UUAAG UGAUGGCAUGCACUAUGCGCG AAACACGCCU 
                 1032 
               
               
                 5505 
                 AAUUUUCCAU A UUUAG 
                 506 
                 CUAAA UGAUGGCAUGCACUAUGCGCG AUGGAAAAUU 
                 1033 
               
               
                 5519 
                 AGAAGUAGAU G CAAAA 
                 507 
                 UUUUG UGAUGGCAUGCACUAUGCGCG AUCUACUUCU 
                 1034 
               
               
                 5532 
                 AAACAAAUCU G CCUUU 
                 508 
                 AAAGG UGAUGGCAUGCACUAUGCGCG AGAUUUGUUU 
                 1035 
               
               
                 5540 
                 CUGCCUUUAU G ACAAA 
                 509 
                 UUUGU UGAUGGCAUGCACUAUGCGCG AUAAAGGCAG 
                 1036 
               
               
                 5551 
                 ACAAAAAAAU A GGAUA 
                 510 
                 UAUCC UGAUGGCAUGCACUAUGCGCG AUUUUUUUGU 
                 1037 
               
               
                 5556 
                 AAAAUAGGAU A ACAUU 
                 511 
                 AAUGU UGAUGGCAUGCACUAUGCGCG AUCCUAUUUU 
                 1038 
               
               
                 5586 
                 UUUUAUCAAU A AGGUA 
                 512 
                 UACCU UGAUGGCAUGCACUAUGCGCG AUUGAUAAAA 
                 1039 
               
               
                 5595 
                 UAAGGUAAUU G AUACA 
                 513 
                 UGUAU UGAUGGCAUGCACUAUGCGCG AAUUACCUUA 
                 1040 
               
               
                 5598 
                 GGUAAUUGAU A CACAA 
                 514 
                 UUGUG UGAUGGCAUGCACUAUGCGCG AUCAAUUACC 
                 1041 
               
               
                 5609 
                 CACAACAGGU G ACUUG 
                 515 
                 CAAGU UGAUGGCAUGCACUAUGCGCG ACCUGUUGUG 
                 1042 
               
               
                 5650 
                 CAACAUUAAU A AUGGA 
                 516 
                 UCCAU UGAUGGCAUGCACUAUGCGCG AUUAAUGUUG 
                 1043 
               
               
                 5653 
                 CAUUAAUAAU G GAAAU 
                 517 
                 AUUUC UGAUGGCAUGCACUAUGCGCG AUUAUUAAUG 
                 1044 
               
               
                 5659 
                 UAAUGGAAAU A AUUGA 
                 518 
                 UCAAU UGAUGGCAUGCACUAUGCGCG AUUUCCAUUA 
                 1045 
               
               
                 5663 
                 GGAAAUAAUU G AAUAG 
                 519 
                 CUAUU UGAUGGCAUGCACUAUGCGCG AAUUAUUUCC 
                 1046 
               
               
                 5667 
                 AUAAUUGAAU A GUUAG 
                 520 
                 CUAAC UGAUGGCAUGCACUAUGCGCG AUUCAAUUAU 
                 1047 
               
               
                 5677 
                 AGUUAGUUAU G UAUGU 
                 521 
                 ACAUA UGAUGGCAUGCACUAUGCGCG AUAACUAACU 
                 1048 
               
               
                 5681 
                 AGUUAUGUAU G UUAAU 
                 522 
                 AUUAA UGAUGGCAUGCACUAUGCGCG AUACAUAACU 
                 1049 
               
               
                 5687 
                 GUAUGUUAAU G CCAGU 
                 523 
                 ACUGG UGAUGGCAUGCACUAUGCGCG AUUAACAUAC 
                 1050 
               
               
                 5725 
                 CAGAAGUAAU G ACUCC 
                 524 
                 GGAGU UGAUGGCAUGCACUAUGCGCG AUUACUUCUG 
                 1051 
               
               
                 5733 
                 AUGACUCCAU A CAUAU 
                 525 
                 AUAUG UGAUGGCAUGCACUAUGCGCG AUGGAGUCAU 
                 1052 
               
               
                 5737 
                 CUCCAUACAU A UUAUU 
                 526 
                 AAUAA UGAUGGCAUGCACUAUGCGCG AUGUAUGGAG 
                 1053 
               
               
                 5752 
                 UUAUUUCUAU A ACUAC 
                 527 
                 GUAGU UGAUGGCAUGCACUAUGCGCG AUAGAAAUAA 
                 1054 
               
               
                   
               
               
                 Input Sequence = KRAS2 Cut Site = AUR/, YG/M or UG/U.  
               
               
                 Stem Length = 5/10. Core Sequence = UGAUGGCAUGCACUAUGCGCG  
               
               
                 Seq1 = KRAS2 ( Homo sapiens  v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog (KRAS2) mRNA.; 5775 bp)  
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE III 
               
             
            
               
                   
               
               
                 Table III. Rate constants for ribozyme 40 cleavage at various triplets 
               
               
                 with next nucleotide specified. Reaction conditions as in text, na = no 
               
               
                 activity detectable, single turnover kinetics. 
               
            
           
           
               
               
               
            
               
                   
                 Cleavable Triplet 
                 k cat  (min −1 ) 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 A 14.2 U 14.1 G 15 /A 1.1   
                 0.91 
               
               
                   
                 A 14.2 U 14.1 A 15 /A 1.1   
                 0.34 
               
               
                   
                 A 14.2 U 14.1 U 15 /A 1.1   
                 0.007 
               
               
                   
                 A 14.2 A 14.1 G 15 /A 1.1   
                 0.57 
               
               
                   
                 A 14.2 U 14.1 G 15 /U 1.1   
                 0.35 
               
               
                   
                 A 14.2 U 14.1 G 15 /G 1.1   
                 0.66 
               
               
                   
                   
               
               
                   
                 / = site of cleavage  
               
               
                   
                 Numbering convention as shown in FIG. 8  
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE IV 
               
             
            
               
                   
               
               
                 Sequence Specificity and Rate Constants for Stabilized Ribozymes 
               
            
           
           
               
               
               
               
               
            
               
                 Cleavage 
                   
                   
                   
                   
               
               
                 Site 
                   
                   
                   
                 k rel to 
               
               
                 Sequence 
                 RPI # 
                 Corresponding Ribozyme 
                 Seq. ID Nos 
                 WT 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 WT = 
                 13159 
                 5′-aac guu GAU s  ggc auG cac uau gcg cga ugg cua ggc-3′ 
                 1055 
                 1 
               
               
                 UG/A 
               
               
                 UG/C 
                 12768 
                 5′-aac ggu GAU s  ggc auG cac uau gcg cga ugg cua ggc-3′ 
                 1056 
                 0.97 
               
               
                 CG/A 
                 13161 
                 5′-aac guu GAU s  ggc auG cac uau gcg cgg ugg cua ggc-3′ 
                 1057 
                 0.76 
               
               
                 AG/A 
                 12763 
                 5′-aac guu GAU s  ggc auG cac uau gcg cgu ugg cua ggc-3′ 
                 1058 
                 0.70 
               
               
                 UG/U 
                 12764 
                 5′-aac gau GAU s  ggc auG cac uau gcg cga ugg cua ggc-3′ 
                 1059 
                 0.35 
               
               
                 CG/U 
                 12766 
                 5′-aac gau GAU s  ggc auG cac uau gcg cgg ugg cua ggc-3′ 
                 1060 
                 0.12 
               
               
                 CG/C 
                 12770 
                 5′-aac ggu GAU s  ggc auG cac uau gcg cgg ugg cua ggc-3′ 
                 1061 
                 0.1 
               
               
                 AG/C 
                 12771 
                 5′-aac ggu GAU s  ggc auG cac uau gcg cgu ugg cua ggc-3′ 
                 1062 
                 0.07 
               
               
                 AG/U 
                 12767 
                 5′-aac gau GAU s  ggc auG cac uau gcg cgu ugg cua ggc-3′ 
                 1063 
                 0.06 
               
               
                 CG/G 
                 12774 
                 5′-aac gcu GAU s  ggc auG cac uau gcg cgg ugg cua ggc-3′ 
                 1064 
                 0.06 
               
               
                 UG/G 
                 12772 
                 5′-aac gcu GAU s  ggc auG cac uau gcg cga ugg cua ggc-3′ 
                 1065 
                 0.04 
               
               
                 GG/A 
                 13160 
                 5′-aac guu GAU s  ggc auG cac uau gcg cgc ugg cua ggc-3′ 
                 1066 
                 0.02 
               
               
                 GG/C 
                 12769 
                 5′-aac ggu GAU s  ggc auG cac uau gcg cgc ugg cua ggc-3′ 
                 1067 
                 0.01 
               
               
                 AG/G 
                 12775 
                 5′-aac gcu GAU s  ggc auG cac uau gcg cgu ugg cua ggc-3′ 
                 1068 
                 0.008 
               
               
                 GG/U 
                 12765 
                 5′-aac gau GAU s  ggc auG cac uau gcg cgc ugg cua ggc-3′ 
                 1069 
                 0.007 
               
               
                 GG/G 
                 12773 
                 5′-aac gcu GAU s  ggc auG cac uau gcg cgc ugg cua ggc-3′ 
                 1070 
                 0.002 
               
               
                   
               
               
                 Lower case = 2′-O-Methyl  
               
               
                 Upper case = Ribo 
               
               
                   s = phosphorothioate  
               
               
                 /= site of cleavage  
               
               
                 WT U 14.1 G 15 /A 1.1  (FIG. 8) K obs = 0.266 min −1    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE V 
               
             
            
               
                   
               
               
                 Human K-ras Ribozyme Sequences 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Nt. 
                   
                   
                 Seq. ID 
               
               
                 RPI # 
                 Position 
                 Alias 
                 Ribozyme Sequence 
                 No. 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 12779 
                 63 
                 krasM-63 GCl.Rz-5/10 stab1 
                 a s g s cug uGAU s g gcauGcacuaugc gcg aucgucaagg  B   
                 1071 
               
               
                 12780 
                 95 
                 krasM-95 GCl.Rz-5/10 stab1 
                 g s a s uca uGAU s g gcauGcacuaugc gcg auucguccac  B   
                 1072 
               
               
                 12781 
                 142 
                 krasM-142 GCl.Rz-5/10 stab1 
                 u s u s cuc uGAU s g gcauGcacuaugc gcg aucaauuacu  B   
                 1073 
               
               
                 12782 
                 163 
                 krasM-163 GCl.Rz-5/10 stab1 
                 g s a s gaa uGAU s g gcauGcacuaugc gcg auccaagaga  B   
                 1074 
               
               
                 12783 
                 201 
                 krasM-201 GCl.Rz-5/10 stab1 
                 u s c s ccu uGAU s g gcauGcacuaugc gcg auugcacugu  B   
                 1075 
               
               
                 12784 
                 216 
                 krasM-216 GCl.Rz-5/10 stab1 
                 g s u s ccu uGAU s g gcauGcacuaugc gcg auguacuggu  B   
                 1076 
               
               
                 12785 
                 256 
                 krasM-256 GCl.Rz-5/10 stab1 
                 a s g s uau uGAU s g gcauGcacuaugc gcg auuuauggca  B   
                 1077 
               
               
                 12786 
                 325 
                 krasM-325 GCl.Rz-5/10 stab1 
                 a s g s gua uGAU s g gcauGcacuaugc gcg aucuucagag  B   
                 1078 
               
               
                 12787 
                 333 
                 krasM-333 GCl.Rz-5/10 stab1 
                 a s g s gac uGAU s g gcauGcacuaugc gcg auagguacau  B   
                 1079 
               
               
                 12788 
                 353 
                 krasM-353 GCl.Rz-5/10 stab1 
                 a s a s uca uGAU s g gcauGcacuaugc gcg auuuauuucc  B   
                 1080 
               
               
                 12789 
                 412 
                 krasM-412 GCl.Rz-5/10 stab1 
                 a s a s uuc uGAU s g gcauGcacuaugc gcg auaacuucuu  B   
                 1081 
               
               
                 12790 
                 460 
                 krasM-460 GCl.Rz-5/10 stab1 
                 g s g s cau uGAU s g gcauGcacuaugc gcg aucaacaccc  B   
                 1082 
               
               
                 12791 
                 463 
                 krasM-463 GCl.Rz-5/10 stab1 
                 g s a s agg uGAU s g gcauGcacuaugc gcg aucaucaaca  B   
                 1083 
               
               
                 12792 
                 472 
                 krasM-472 GCl.Rz-5/10 stab1 
                 u s a s aug uGAU s g gcauGcacuaugc gcg auagaaggca  B   
                 1084 
               
               
                 12793 
                 520 
                 krasM-520 GCl.Rz-5/10 stab1 
                 u s u s uac uGAU s g gcauGcacuaugc gcg aucuuugcuc  B   
                 1085 
               
               
                 12794 
                 706 
                 krasM-706 GCl.Rz-5/10 stab1 
                 a s u s aag uGAU s g gcauGcacuaugc gcg auuuaaggua  B   
                 1086 
               
               
                 12795 
                 787 
                 krasM-787 GCl.Rz-5/10 stab1 
                 a s c s agg uGAU s g gcauGcacuaugc gcg auugcuaguu  B   
                 1087 
               
               
                 12796 
                 843 
                 krasM-843 GCl.Rz-5/10 stab1 
                 a s a s cug uGAU s g gcauGcacuaugc gcg augcaccaaa  B   
                 1088 
               
               
                 12797 
                 882 
                 krasM-882 GCl.Rz-5/10 stab1 
                 a s c s caa uGAU s g gcauGcacuaugc gcg auucacacuu  B   
                 1089 
               
               
                 12798 
                 903 
                 krasM-903 GCl.Rz-5/10 stab1 
                 a s g s cuu uGAU s g gcauGcacuaugc gcg auuaauuugu  B   
                 1090 
               
               
                 12799 
                 951 
                 krasM-951 GCl.Rz-5/10 stab1 
                 u s a s auc uGAU s g gcauGcacuaugc gcg auuuauguga  B   
                 1091 
               
               
                 12800 
                 1022 
                 krasM-1022 GCl.Rz-5/10 stab1 
                 a s a s gcc uGAU s g gcauGcacuaugc gcg auaaauuugu  B   
                 1092 
               
               
                 12801 
                 1034 
                 krasM-1034 GCl.Rz-5/10 stab1 
                 a s u s cau uGAU s g gcauGcacuaugc gcg aucaggaagc  B   
                 1093 
               
               
                 12802 
                 1037 
                 krasM-1037 GCl.Rz-5/10 stab1 
                 a s g s aau uGAU s g gcauGcacuaugc gcg aucaucagga  B   
                 1094 
               
               
                 12803 
                 1079 
                 krasM-1079 GCl.Rz-5/10 stab1 
                 a s c s auu uGAU s g gcauGcacuaugc gcg aucagggaug  B   
                 1095 
               
               
                 12804 
                 1083 
                 krasM-1083 GCl.Rz-5/10 stab1 
                 c s u s uua uGAU s g gcauGcacuaugc gcg auucaucagg  B   
                 1096 
               
               
                 12805 
                 1206 
                 krasM-1206 GCl.Rz-5/10 stab1 
                 g s u s uuc uGAU s g gcauGcacuaugc gcg auugccuugu  B   
                 1097 
               
               
                 12806 
                 1218 
                 krasM-1218 GCl.Rz-5/10 stab1 
                 g s g s ccu uGAU s g gcauGcacuaugc gcg auaauaguuu  B   
                 1098 
               
               
                 12807 
                 1267 
                 krasM-1267 GCl.Rz-5/10 stab1 
                 a s a s agc uGAU s g gcauGcacuaugc gcg auuaggaguc  B   
                 1099 
               
               
                 12808 
                 1301 
                 krasM-1301 GCl.Rz-5/10 stab1 
                 a s a s ucc uGAU s g gcauGcacuaugc gcg auucauacug  B   
                 1100 
               
               
                 12809 
                 1312 
                 krasM-1312 GCl.Rz-5/10 stab1 
                 g s u s ugc uGAU s g gcauGcacuaugc gcg auaauaaucc  B   
                 1101 
               
               
                 12810 
                 1529 
                 krasM-1529 GCl.Rz-5/10 stab1 
                 u s a s agc uGAU s g gcauGcacuaugc gcg auaacuggcc  B   
                 1102 
               
               
                 12811 
                 1594 
                 krasM-1594 GCl.Rz-5/10 stab1 
                 c s u s cuc uGAU s g gcauGcacuaugc gcg augaaagcuc  B   
                 1103 
               
               
                 12812 
                 1611 
                 krasM-1611 GCl.Rz-5/10 stab1 
                 c s a s guc uGAU s g gcauGcacuaugc gcg augcugugaa  B   
                 1104 
               
               
                 12813 
                 1650 
                 krasM-1650 GCl.Rz-5/10 stab1 
                 c s a s aug uGAU s g gcauGcacuaugc gcg aucguacaac  B   
                 1105 
               
               
                 12814 
                 1694 
                 krasM-1694 GCl.Rz-5/10 stab1 
                 u s g s agc uGAU s g gcauGcacuaugc gcg auccaaacug  B   
                 1106 
               
               
                 12815 
                 1867 
                 krasM-1867 GCl.Rz-5/10 stab1 
                 c s a s cuu uGAU s g gcauGcacuaugc gcg auuguuuaaa  B   
                 1107 
               
               
                 12816 
                 1936 
                 krasM-1936 GCl.Rz-5/10 stab1 
                 g s u s guu uGAU s g gcauGcacuaugc gcg augcaauguu  B   
                 1108 
               
               
                 12817 
                 1960 
                 krasM-1960 GCl.Rz-5/10 stab1 
                 u s u s aaa uGAU s g gcauGcacuaugc gcq auggaucaga  B   
                 1109 
               
               
                 12818 
                 2046 
                 krasM-2046 GCl.Rz-5/10 stab1 
                 c s a s ugc uGAU s g gcauGcacuaugc gcg aucucacuuc  B   
                 1110 
               
               
                 12819 
                 2051 
                 krasM-2051 GCl.Rz-5/10 stab1 
                 c s u s cac uGAU s g gcauGcacuaugc gcg augccaucuc  B   
                 1111 
               
               
                 12820 
                 2103 
                 krasM-2103 GCl.Rz-5/10 stab1 
                 a s c s acc uGAU s g gcauGcacuaugc gcg aucuagaacc  B   
                 1112 
               
               
                 12821 
                 2158 
                 krasM-2158 GCl.Rz-5/10 stab1 
                 u s u s uaa uGAU s g gcauGcacuaugc gcg augaagaaau  B   
                 1113 
               
               
                 12822 
                 2214 
                 krasM-2214 GCl.Rz-5/10 stab1 
                 u s g s gaa uGAU s g gcauGcacuaugc gcg auaaaucaca  B   
                 1114 
               
               
                 12823 
                 2227 
                 krasM-2227 GCl.Rz-5/10 stab1 
                 a s u s ccu uGAU s g gcauGcacuaugc gcg auguaaaugg  B   
                 1115 
               
               
                 12824 
                 2422 
                 krasM-2422 GCl.Rz-5/10 stab1 
                 a s a s cug uGAU s g gcauGcacuaugc gcg aucaagucau  B   
                 1116 
               
               
                 12825 
                 2454 
                 krasM-2454 GCl.Rz-5/10 stab1 
                 a s a s ucu uGAU s g gcauGcacuaugc gcg augguuaggg  B   
                 1117 
               
               
                 12826 
                 2476 
                 krasM-2476 GCl.Rz-5/10 stab1 
                 g s g s aga uGAU s g gcauGcacuaugc gcg auccacagca  B   
                 1118 
               
               
                 12827 
                 2484 
                 krasM-2484 GCl.Rz-5/10 stab1 
                 a s a s cuu uGAU s g gcauGcacuaugc gcg auggagauau  B   
                 1119 
               
               
                 12828 
                 2514 
                 krasM-2514 GCl.Rz-5/10 stab1 
                 u s a s ggg uGAU s g gcauGcacuaugc gcg auuucugaug  B   
                 1120 
               
               
                 12829 
                 2564 
                 krasM-2564 GCl Rz-5/10 stab1 
                 c s c s cuu uGAU s g gcauGcacuaugc gcg augguaucug  B   
                 1121 
               
               
                 12830 
                 2607 
                 krasM-2607 GCl.Rz-5/10 stab1 
                 c s a s aag uGAU s g gcauGcacuaugc gcg aucagccacc  B   
                 1122 
               
               
                 12831 
                 2669 
                 krasM-2669 GCl.Rz-5/10 stab1 
                 c s u s auu uGAU s g gcauGcacuaugc gcg auaccagggu  B   
                 1123 
               
               
                 12832 
                 2806 
                 krasM-2806 GCl.Rz-5/10 stab1 
                 c s a s uug uGAU s g gcauGcacuaugc gcg augaagauuu  B   
                 1124 
               
               
                 12833 
                 2830 
                 krasM-2830 GCl.Rz-5/10 stab1 
                 a s g s cuu uGAU s g gcauGcacuaugc gcg augaauuaaa  B   
                 1125 
               
               
                 12834 
                 2888 
                 krasM-2888 GCl.Rz-5/10 stab1 
                 c s a s cug uGAU s g gcauGcacuaugc gcg auuccagccu  B   
                 1126 
               
               
                 12835 
                 3095 
                 krasM-3095 GCl.Rz-5/10 stab1 
                 a s g s guu uGAU s g gcauGcacuaugc gcg augaggccaa  B   
                 1127 
               
               
                 12836 
                 3130 
                 krasM-3130 GCl.Rz-5/10 stab1 
                 a s u s aaa uGAU s g gcauGcacuaugc gcg auuugcugaa  B   
                 1128 
               
               
                 12837 
                 3152 
                 krasM-3152 GCl.Rz-5/10 stab1 
                 a s c s ugg uGAU s g gcauGcacuaugc gcg aucugguagg  B   
                 1129 
               
               
                 12838 
                 3180 
                 krasM-3180 GCl.Rz-5/10 stab1 
                 u s a s cca uGAU s g gcauGcacuaugc gcg auacccagug  B   
                 1130 
               
               
                 12839 
                 3182 
                 krasM-3182 GCl.Rz-5/10 stab1 
                 g s a s uac uGAU s g gcauGcacuaugc gcg auauacccag  B   
                 1131 
               
               
                 12840 
                 3204 
                 krasM-3204 GCl.Rz-5/10 stab1 
                 g s g s gau uGAU s g gcauGcacuaugc gcg augucucuug  B   
                 1132 
               
               
                 12841 
                 3264 
                 krasM-3264 GCl.Rz-5/10 stab1 
                 g s g s ucg uGAU s g gcauGcacuaugc gcg auaccaaagg  B   
                 1133 
               
               
                 12842 
                 3277 
                 krasM-3277 GCl.Rz-5/10 stab1 
                 c s g s ugu uGAU s g gcauGcacuaugc gcg aucucugggu  B   
                 1134 
               
               
                 12843 
                 3285 
                 krasM-3285 GCl.Rz-5/10 stab1 
                 a s u s acg uGAU s g gcauGcacuaugc gcg aucguguuau  B   
                 1135 
               
               
                 12844 
                 3335 
                 krasM-3335 GCl.Rz-5/10 stab1 
                 a s c s aau uGAU s g gcauGcacuaugc gcg auagagcugg  B   
                 1136 
               
               
                 12845 
                 3412 
                 krasM-3412 GCl.Rz-5/10 stab1 
                 a s a s guu uGAU s g gcauGcacuaugc gcg auuccuuuaa  B   
                 1137 
               
               
                 12846 
                 3444 
                 krasM-3444 GCl.Rz-5/10 stab1 
                 a s c s agu uGAU s g gcauGcacuaugc gcg augccaaaua  B   
                 1138 
               
               
                 12847 
                 3514 
                 krasM-3514 GCl.Rz-5/10 stab1 
                 u s u s aca uGAU s g gcauGcacuaugc gcg auuuggguca  B   
                 1139 
               
               
                 12848 
                 3521 
                 krasM-3521 GCl.Rz-5/10 stab1 
                 u s g s gaa uGAU s g gcauGcacuaugc gcg auuacacauu  B   
                 1140 
               
               
                 12849 
                 3540 
                 krasM-3540 GCl.Rz-5/10 stab1 
                 u s u s acu uGAU s g gcauGcacuaugc gcg augcagagaa  B   
                 1141 
               
               
                 12850 
                 3589 
                 krasM-3589 GCl.Rz-5/10 stab1 
                 c s u s guu uGAU s g gcauGcacuaugc gcg auuuguaccc  B   
                 1142 
               
               
                 12851 
                 3662 
                 krasM-3662 GCl.Rz-5/10 stab1 
                 u s u s uca uGAU s g gcauGcacuaugc gcg auagcaauuc  B   
                 1143 
               
               
                 12852 
                 3746 
                 krasM-3746 GCl.Rz-5/10 stab1 
                 a s u s ggc uGAU s g gcauGcacuaugc gcg auuucuuucu  B   
                 1144 
               
               
                 12853 
                 3752 
                 krasM-3752 GCl.Rz-5/10 stab1 
                 u s g s aag uGAU s g gcauGcacuaugc gcg auggccauuu  B   
                 1145 
               
               
                 12854 
                 3813 
                 krasM-3813 GCl.Rz-5/10 stab1 
                 a s u s gcc uGAU s g gcauGcacuaugc gcg aucuacauca  B   
                 1146 
               
               
                 12855 
                 3849 
                 krasM-3849 GCl.Rz-5/10 stab1 
                 g s u s uca uGAU s g gcauGcacuaugc gcg auaaagguaa  B   
                 1147 
               
               
                 12856 
                 3862 
                 krasM-3862 GCl.Rz-5/10 stab1 
                 u s a s aac uGAU s g gcauGcacuaugc gcg auucaaaguu  B   
                 1148 
               
               
                 12857 
                 4012 
                 krasM-4012 GCl.Rz-5/10 stab1 
                 a s c s aaa uGAU s g gcauGcacuaugc gcg auguuaaugc  B   
                 1149 
               
               
                 12858 
                 4026 
                 krasM-4026 GCl.Rz-5/10 stab1 
                 u s g s cua uGAU s g gcauGcacuaugc gcg auucuuccac  B   
                 1150 
               
               
                 12859 
                 4028 
                 krasM-4028 GCl.Rz-5/10 stab1 
                 u s c s ugc uGAU s g gcauGcacuaugc gcg auauucuucc  B   
                 1151 
               
               
                 12860 
                 4039 
                 krasM-4039 GCl.Rz-5/10 stab1 
                 u s a s caa uGAU s g gcauGcacuaugc gcg auacgucugc  B   
                 1152 
               
               
                 12861 
                 4059 
                 krasM-4059 GCl.Rz-5/10 stab1 
                 g s g s gaa uGAU s g gcauGcacuaugc gcg auucacucaa  B   
                 1153 
               
               
                 12862 
                 4107 
                 krasM-4107 GCl.Rz-5/10 stab1 
                 a s u s ucc uGAU s g gcauGcacuaugc gcg augcagugug  B   
                 1154 
               
               
                 12863 
                 4458 
                 krasM-4458 GCl.Rz-5/10 stab1 
                 c s a s ugc uGAU s g gcauGcacuaugc gcg auccaguauu  B   
                 1155 
               
               
                 12864 
                 4463 
                 krasM-4463 GCl.Rz-5/10 stab1 
                 g s a s auu uGAU s g gcauGcacuaugc gcg augcuaucca  B   
                 1156 
               
               
                 12865 
                 4487 
                 krasM-4487 GCl.Rz-5/10 stab1 
                 a s c s agc uGAU s g gcauGcacuaugc gcg auucaguuuc  B   
                 1157 
               
               
                 12866 
                 4606 
                 krasM-4606 GCl.Rz-5/10 stab1 
                 a s u s cau uGAU s g gcauGcacuaugc gcg aucccaaaca  B   
                 1158 
               
               
                 12867 
                 4609 
                 krasM-4609 GCl.Rz-5/10 stab1 
                 c s c s uau uGAU s g gcauGcacuaugc gcg auuaucccaa  B   
                 1159 
               
               
                 12868 
                 4659 
                 krasM-4659 GCl.Rz-5/10 stab1 
                 c s u s caa uGAU s g gcauGcacuaugc gcg auaacugcag  B   
                 1160 
               
               
                 12869 
                 4875 
                 krasM-4875 GCl.Rz-5/10 stab1 
                 a s u s gug uGAU s g gcauGcacuaugc gcg auguuucagu  B   
                 1161 
               
               
                 12870 
                 4912 
                 krasM-4912 GCl.Rz-5/10 stab1 
                 c s u s gca uGAU s g gcauGcacuaugc gcg augacccaca  B   
                 1162 
               
               
                 12871 
                 4914 
                 krasM-4914 GCl.Rz-5/10 stab1 
                 c s a s cug uGAU s g gcauGcacuaugc gcg auaugaccca  B   
                 1163 
               
               
                 12872 
                 4964 
                 krasM-4964 GCl.Rz-5/10 stab1 
                 a s c s caa uGAU s g gcauGcacuaugc gcg auuccuaggu  B   
                 1164 
               
               
                 12873 
                 4973 
                 krasM-4973 GCl.Rz-5/10 stab1 
                 u s u s uga uGAU s g gcauGcacuaugc gcg augaccaaca  B   
                 1165 
               
               
                 12874 
                 5035 
                 krasM-5035 GCl.Rz-5/10 stab1 
                 c s a s gca uGAU s g gcauGcacuaugc gcg auacuccuau  B   
                 1166 
               
               
                   
               
               
                 Lower Case = 2′-O-methyl  
               
               
                 Upper Case = Ribo  
               
               
                 s = phosphorothioate linkage  
               
               
                 B = inverted deoxyabasic  
               
            
           
         
       
     
     
       
         
           
             1208 
           
           
             1 
             16 
             RNA 
             Homo sapiens 
           
            1
ggcggcggcc gcggcg                                                     16
 
           
             2 
             16 
             RNA 
             Homo sapiens 
           
            2
uggcggcggc gaaggu                                                     16
 
           
             3 
             16 
             RNA 
             Homo sapiens 
           
            3
cccggccccc gccauu                                                     16
 
           
             4 
             16 
             RNA 
             Homo sapiens 
           
            4
gacugggagc gagcgc                                                     16
 
           
             5 
             16 
             RNA 
             Homo sapiens 
           
            5
gggagcgagc gcggcg                                                     16
 
           
             6 
             16 
             RNA 
             Homo sapiens 
           
            6
cgagcgcggc gcaggc                                                     16
 
           
             7 
             16 
             RNA 
             Homo sapiens 
           
            7
cgcaggcacu gaaggc                                                     16
 
           
             8 
             16 
             RNA 
             Homo sapiens 
           
            8
gcucccaggu gcggga                                                     16
 
           
             9 
             16 
             RNA 
             Homo sapiens 
           
            9
agagaggccu gcugaa                                                     16
 
           
             10 
             16 
             RNA 
             Homo sapiens 
           
            10
gaggccugcu gaaaau                                                     16
 
           
             11 
             16 
             RNA 
             Homo sapiens 
           
            11
ugcugaaaau gacuga                                                     16
 
           
             12 
             16 
             RNA 
             Homo sapiens 
           
            12
gaaaaugacu gaauau                                                     16
 
           
             13 
             16 
             RNA 
             Homo sapiens 
           
            13
augacugaau auaaac                                                     16
 
           
             14 
             16 
             RNA 
             Homo sapiens 
           
            14
gacugaauau aaacuu                                                     16
 
           
             15 
             16 
             RNA 
             Homo sapiens 
           
            15
auauaaacuu guggua                                                     16
 
           
             16 
             16 
             RNA 
             Homo sapiens 
           
            16
guuggagcuu guggcg                                                     16
 
           
             17 
             16 
             RNA 
             Homo sapiens 
           
            17
aggcaagagu gccuug                                                     16
 
           
             18 
             16 
             RNA 
             Homo sapiens 
           
            18
agagugccuu gacgau                                                     16
 
           
             19 
             16 
             RNA 
             Homo sapiens 
           
            19
gugccuugac gauaca                                                     16
 
           
             20 
             16 
             RNA 
             Homo sapiens 
           
            20
ccuugacgau acagcu                                                     16
 
           
             21 
             16 
             RNA 
             Homo sapiens 
           
            21
gaaucauuuu guggac                                                     16
 
           
             22 
             16 
             RNA 
             Homo sapiens 
           
            22
uuuuguggac gaauau                                                     16
 
           
             23 
             16 
             RNA 
             Homo sapiens 
           
            23
guggacgaau augauc                                                     16
 
           
             24 
             16 
             RNA 
             Homo sapiens 
           
            24
ggacgaauau gaucca                                                     16
 
           
             25 
             16 
             RNA 
             Homo sapiens 
           
            25
auccaacaau agagga                                                     16
 
           
             26 
             16 
             RNA 
             Homo sapiens 
           
            26
aguaguaauu gaugga                                                     16
 
           
             27 
             16 
             RNA 
             Homo sapiens 
           
            27
aguaauugau ggagaa                                                     16
 
           
             28 
             16 
             RNA 
             Homo sapiens 
           
            28
ggagaaaccu gucucu                                                     16
 
           
             29 
             16 
             RNA 
             Homo sapiens 
           
            29
ucucuuggau auucuc                                                     16
 
           
             30 
             16 
             RNA 
             Homo sapiens 
           
            30
ggauauucuc gacaca                                                     16
 
           
             31 
             16 
             RNA 
             Homo sapiens 
           
            31
ggaguacagu gcaaug                                                     16
 
           
             32 
             16 
             RNA 
             Homo sapiens 
           
            32
acagugcaau gaggga                                                     16
 
           
             33 
             16 
             RNA 
             Homo sapiens 
           
            33
accaguacau gaggac                                                     16
 
           
             34 
             16 
             RNA 
             Homo sapiens 
           
            34
ggcuuucuuu guguau                                                     16
 
           
             35 
             16 
             RNA 
             Homo sapiens 
           
            35
cuuucuuugu guauuu                                                     16
 
           
             36 
             16 
             RNA 
             Homo sapiens 
           
            36
uuguguauuu gccaua                                                     16
 
           
             37 
             16 
             RNA 
             Homo sapiens 
           
            37
uauuugccau aaauaa                                                     16
 
           
             38 
             16 
             RNA 
             Homo sapiens 
           
            38
ugccauaaau aauacu                                                     16
 
           
             39 
             16 
             RNA 
             Homo sapiens 
           
            39
cauaaauaau acuaaa                                                     16
 
           
             40 
             16 
             RNA 
             Homo sapiens 
           
            40
uaaaucauuu gaagau                                                     16
 
           
             41 
             16 
             RNA 
             Homo sapiens 
           
            41
auuugaagau auucac                                                     16
 
           
             42 
             16 
             RNA 
             Homo sapiens 
           
            42
ucaccauuau agagaa                                                     16
 
           
             43 
             16 
             RNA 
             Homo sapiens 
           
            43
uaaggacucu gaagau                                                     16
 
           
             44 
             16 
             RNA 
             Homo sapiens 
           
            44
cucugaagau guaccu                                                     16
 
           
             45 
             16 
             RNA 
             Homo sapiens 
           
            45
auguaccuau gguccu                                                     16
 
           
             46 
             16 
             RNA 
             Homo sapiens 
           
            46
aguaggaaau aaaugu                                                     16
 
           
             47 
             16 
             RNA 
             Homo sapiens 
           
            47
ggaaauaaau gugauu                                                     16
 
           
             48 
             16 
             RNA 
             Homo sapiens 
           
            48
aaauaaaugu gauuug                                                     16
 
           
             49 
             16 
             RNA 
             Homo sapiens 
           
            49
aaugugauuu gccuuc                                                     16
 
           
             50 
             16 
             RNA 
             Homo sapiens 
           
            50
aagaaguuau ggaauu                                                     16
 
           
             51 
             16 
             RNA 
             Homo sapiens 
           
            51
uccuuuuauu gaaaca                                                     16
 
           
             52 
             16 
             RNA 
             Homo sapiens 
           
            52
aagacagggu guugau                                                     16
 
           
             53 
             16 
             RNA 
             Homo sapiens 
           
            53
acaggguguu gaugau                                                     16
 
           
             54 
             16 
             RNA 
             Homo sapiens 
           
            54
ggguguugau gaugcc                                                     16
 
           
             55 
             16 
             RNA 
             Homo sapiens 
           
            55
uguugaugau gccuuc                                                     16
 
           
             56 
             16 
             RNA 
             Homo sapiens 
           
            56
ugccuucuau acauua                                                     16
 
           
             57 
             16 
             RNA 
             Homo sapiens 
           
            57
acauuaguuc gagaaa                                                     16
 
           
             58 
             16 
             RNA 
             Homo sapiens 
           
            58
cgagaaauuc gaaaac                                                     16
 
           
             59 
             16 
             RNA 
             Homo sapiens 
           
            59
ucgaaaacau aaagaa                                                     16
 
           
             60 
             16 
             RNA 
             Homo sapiens 
           
            60
aagaaaagau gagcaa                                                     16
 
           
             61 
             16 
             RNA 
             Homo sapiens 
           
            61
gagcaaagau gguaaa                                                     16
 
           
             62 
             16 
             RNA 
             Homo sapiens 
           
            62
aagacaaagu guguaa                                                     16
 
           
             63 
             16 
             RNA 
             Homo sapiens 
           
            63
gacaaagugu guaauu                                                     16
 
           
             64 
             16 
             RNA 
             Homo sapiens 
           
            64
guguaauuau guaaau                                                     16
 
           
             65 
             16 
             RNA 
             Homo sapiens 
           
            65
uuauguaaau acaauu                                                     16
 
           
             66 
             16 
             RNA 
             Homo sapiens 
           
            66
aauacaauuu guacuu                                                     16
 
           
             67 
             16 
             RNA 
             Homo sapiens 
           
            67
cuuaaggcau acuagu                                                     16
 
           
             68 
             16 
             RNA 
             Homo sapiens 
           
            68
gguaauuuuu guacau                                                     16
 
           
             69 
             16 
             RNA 
             Homo sapiens 
           
            69
auuagcauuu guuuua                                                     16
 
           
             70 
             16 
             RNA 
             Homo sapiens 
           
            70
uuuuuuuccu gcucca                                                     16
 
           
             71 
             16 
             RNA 
             Homo sapiens 
           
            71
ccugcuccau gcagac                                                     16
 
           
             72 
             16 
             RNA 
             Homo sapiens 
           
            72
caugcagacu guuagc                                                     16
 
           
             73 
             16 
             RNA 
             Homo sapiens 
           
            73
uaccuuaaau gcuuau                                                     16
 
           
             74 
             16 
             RNA 
             Homo sapiens 
           
            74
auuuuaaaau gacagu                                                     16
 
           
             75 
             16 
             RNA 
             Homo sapiens 
           
            75
uuuuuuccuc gaagug                                                     16
 
           
             76 
             16 
             RNA 
             Homo sapiens 
           
            76
uccucgaagu gccagu                                                     16
 
           
             77 
             16 
             RNA 
             Homo sapiens 
           
            77
uuugguuuuu gaacua                                                     16
 
           
             78 
             16 
             RNA 
             Homo sapiens 
           
            78
aacuagcaau gccugu                                                     16
 
           
             79 
             16 
             RNA 
             Homo sapiens 
           
            79
agcaaugccu gugaaa                                                     16
 
           
             80 
             16 
             RNA 
             Homo sapiens 
           
            80
caaugccugu gaaaaa                                                     16
 
           
             81 
             16 
             RNA 
             Homo sapiens 
           
            81
aaaagaaacu gaauac                                                     16
 
           
             82 
             16 
             RNA 
             Homo sapiens 
           
            82
gaaacugaau accuaa                                                     16
 
           
             83 
             16 
             RNA 
             Homo sapiens 
           
            83
uaagauuucu gucuug                                                     16
 
           
             84 
             16 
             RNA 
             Homo sapiens 
           
            84
gguuuuuggu gcaugc                                                     16
 
           
             85 
             16 
             RNA 
             Homo sapiens 
           
            85
uuuggugcau gcaguu                                                     16
 
           
             86 
             16 
             RNA 
             Homo sapiens 
           
            86
gcaugcaguu gauuac                                                     16
 
           
             87 
             16 
             RNA 
             Homo sapiens 
           
            87
cuuaccaagu gugaau                                                     16
 
           
             88 
             16 
             RNA 
             Homo sapiens 
           
            88
uaccaagugu gaaugu                                                     16
 
           
             89 
             16 
             RNA 
             Homo sapiens 
           
            89
aagugugaau guuggu                                                     16
 
           
             90 
             16 
             RNA 
             Homo sapiens 
           
            90
gaauguuggu gugaaa                                                     16
 
           
             91 
             16 
             RNA 
             Homo sapiens 
           
            91
auguuggugu gaaaca                                                     16
 
           
             92 
             16 
             RNA 
             Homo sapiens 
           
            92
acaaauuaau gaagcu                                                     16
 
           
             93 
             16 
             RNA 
             Homo sapiens 
           
            93
ugaagcuuuu gaauca                                                     16
 
           
             94 
             16 
             RNA 
             Homo sapiens 
           
            94
ucccuauucu guguuu                                                     16
 
           
             95 
             16 
             RNA 
             Homo sapiens 
           
            95
ccuauucugu guuuua                                                     16
 
           
             96 
             16 
             RNA 
             Homo sapiens 
           
            96
cuagucacau aaaugg                                                     16
 
           
             97 
             16 
             RNA 
             Homo sapiens 
           
            97
ucacauaaau ggauua                                                     16
 
           
             98 
             16 
             RNA 
             Homo sapiens 
           
            98
aauuucaguu gagacc                                                     16
 
           
             99 
             16 
             RNA 
             Homo sapiens 
           
            99
gguuuuuacu gaaaca                                                     16
 
           
             100 
             16 
             RNA 
             Homo sapiens 
           
            100
cugaaacauu gaggga                                                     16
 
           
             101 
             16 
             RNA 
             Homo sapiens 
           
            101
acaaauuuau gggcuu                                                     16
 
           
             102 
             16 
             RNA 
             Homo sapiens 
           
            102
ugggcuuccu gaugau                                                     16
 
           
             103 
             16 
             RNA 
             Homo sapiens 
           
            103
gcuuccugau gaugau                                                     16
 
           
             104 
             16 
             RNA 
             Homo sapiens 
           
            104
uccugaugau gauucu                                                     16
 
           
             105 
             16 
             RNA 
             Homo sapiens 
           
            105
uaggcaucau guccua                                                     16
 
           
             106 
             16 
             RNA 
             Homo sapiens 
           
            106
cauguccuau aguuug                                                     16
 
           
             107 
             16 
             RNA 
             Homo sapiens 
           
            107
ccuauaguuu gucauc                                                     16
 
           
             108 
             16 
             RNA 
             Homo sapiens 
           
            108
ugucaucccu gaugaa                                                     16
 
           
             109 
             16 
             RNA 
             Homo sapiens 
           
            109
caucccugau gaaugu                                                     16
 
           
             110 
             16 
             RNA 
             Homo sapiens 
           
            110
ccugaugaau guaaag                                                     16
 
           
             111 
             16 
             RNA 
             Homo sapiens 
           
            111
aaguuacacu guucac                                                     16
 
           
             112 
             16 
             RNA 
             Homo sapiens 
           
            112
caaagguuuu gucucc                                                     16
 
           
             113 
             16 
             RNA 
             Homo sapiens 
           
            113
ccuuuccacu gcuauu                                                     16
 
           
             114 
             16 
             RNA 
             Homo sapiens 
           
            114
uauuagucau ggucac                                                     16
 
           
             115 
             16 
             RNA 
             Homo sapiens 
           
            115
uccccaaaau auuaua                                                     16
 
           
             116 
             16 
             RNA 
             Homo sapiens 
           
            116
aaaauauuau auuuuu                                                     16
 
           
             117 
             16 
             RNA 
             Homo sapiens 
           
            117
uuuuuucuau aaaaag                                                     16
 
           
             118 
             16 
             RNA 
             Homo sapiens 
           
            118
agaaaaaaau ggaaaa                                                     16
 
           
             119 
             16 
             RNA 
             Homo sapiens 
           
            119
acaaggcaau ggaaac                                                     16
 
           
             120 
             16 
             RNA 
             Homo sapiens 
           
            120
aaacuauuau aaggcc                                                     16
 
           
             121 
             16 
             RNA 
             Homo sapiens 
           
            121
cacauuagau aaauua                                                     16
 
           
             122 
             16 
             RNA 
             Homo sapiens 
           
            122
aaauuacuau aaagac                                                     16
 
           
             123 
             16 
             RNA 
             Homo sapiens 
           
            123
gacuccuaau agcuuu                                                     16
 
           
             124 
             16 
             RNA 
             Homo sapiens 
           
            124
gcuuuuuccu guuaag                                                     16
 
           
             125 
             16 
             RNA 
             Homo sapiens 
           
            125
gacccaguau gaaugg                                                     16
 
           
             126 
             16 
             RNA 
             Homo sapiens 
           
            126
caguaugaau gggauu                                                     16
 
           
             127 
             16 
             RNA 
             Homo sapiens 
           
            127
ggauuauuau agcaac                                                     16
 
           
             128 
             16 
             RNA 
             Homo sapiens 
           
            128
uuggggcuau auuuac                                                     16
 
           
             129 
             16 
             RNA 
             Homo sapiens 
           
            129
auauuuacau gcuacu                                                     16
 
           
             130 
             16 
             RNA 
             Homo sapiens 
           
            130
aaauuuuuau aauaau                                                     16
 
           
             131 
             16 
             RNA 
             Homo sapiens 
           
            131
uuuuuauaau aauuga                                                     16
 
           
             132 
             16 
             RNA 
             Homo sapiens 
           
            132
uauaauaauu gaaaag                                                     16
 
           
             133 
             16 
             RNA 
             Homo sapiens 
           
            133
uaacaaguau aaaaaa                                                     16
 
           
             134 
             16 
             RNA 
             Homo sapiens 
           
            134
aaauucucau aggaau                                                     16
 
           
             135 
             16 
             RNA 
             Homo sapiens 
           
            135
ggaauuaaau guaguc                                                     16
 
           
             136 
             16 
             RNA 
             Homo sapiens 
           
            136
uagucucccu guguca                                                     16
 
           
             137 
             16 
             RNA 
             Homo sapiens 
           
            137
gucucccugu gucaga                                                     16
 
           
             138 
             16 
             RNA 
             Homo sapiens 
           
            138
gugucagacu gcucuu                                                     16
 
           
             139 
             16 
             RNA 
             Homo sapiens 
           
            139
gcucuuucau aguaua                                                     16
 
           
             140 
             16 
             RNA 
             Homo sapiens 
           
            140
uucauaguau aacuuu                                                     16
 
           
             141 
             16 
             RNA 
             Homo sapiens 
           
            141
ucuucaacuu gagucu                                                     16
 
           
             142 
             16 
             RNA 
             Homo sapiens 
           
            142
uugagucuuu gaagau                                                     16
 
           
             143 
             16 
             RNA 
             Homo sapiens 
           
            143
cuuugaagau aguuuu                                                     16
 
           
             144 
             16 
             RNA 
             Homo sapiens 
           
            144
uuuuaauucu gcuugu                                                     16
 
           
             145 
             16 
             RNA 
             Homo sapiens 
           
            145
aauucugcuu gugaca                                                     16
 
           
             146 
             16 
             RNA 
             Homo sapiens 
           
            146
uucugcuugu gacauu                                                     16
 
           
             147 
             16 
             RNA 
             Homo sapiens 
           
            147
ggccaguuau agcuua                                                     16
 
           
             148 
             16 
             RNA 
             Homo sapiens 
           
            148
cuuauuaggu guugaa                                                     16
 
           
             149 
             16 
             RNA 
             Homo sapiens 
           
            149
auuagguguu gaagag                                                     16
 
           
             150 
             16 
             RNA 
             Homo sapiens 
           
            150
gaccaagguu gcaagc                                                     16
 
           
             151 
             16 
             RNA 
             Homo sapiens 
           
            151
gccaggcccu guguga                                                     16
 
           
             152 
             16 
             RNA 
             Homo sapiens 
           
            152
caggcccugu gugaac                                                     16
 
           
             153 
             16 
             RNA 
             Homo sapiens 
           
            153
ggcccugugu gaaccu                                                     16
 
           
             154 
             16 
             RNA 
             Homo sapiens 
           
            154
ugugaaccuu gagcuu                                                     16
 
           
             155 
             16 
             RNA 
             Homo sapiens 
           
            155
gagcuuucau agagag                                                     16
 
           
             156 
             16 
             RNA 
             Homo sapiens 
           
            156
uucacagcau ggacug                                                     16
 
           
             157 
             16 
             RNA 
             Homo sapiens 
           
            157
agcauggacu gugugc                                                     16
 
           
             158 
             16 
             RNA 
             Homo sapiens 
           
            158
cauggacugu gugccc                                                     16
 
           
             159 
             16 
             RNA 
             Homo sapiens 
           
            159
uggacugugu gcccca                                                     16
 
           
             160 
             16 
             RNA 
             Homo sapiens 
           
            160
acggucaucc gagugg                                                     16
 
           
             161 
             16 
             RNA 
             Homo sapiens 
           
            161
ccgagugguu guacga                                                     16
 
           
             162 
             16 
             RNA 
             Homo sapiens 
           
            162
gugguuguac gaugca                                                     16
 
           
             163 
             16 
             RNA 
             Homo sapiens 
           
            163
guuguacgau gcauug                                                     16
 
           
             164 
             16 
             RNA 
             Homo sapiens 
           
            164
agucaaaaau ggggag                                                     16
 
           
             165 
             16 
             RNA 
             Homo sapiens 
           
            165
caguuuggau agcuca                                                     16
 
           
             166 
             16 
             RNA 
             Homo sapiens 
           
            166
ucaacaagau acaauc                                                     16
 
           
             167 
             16 
             RNA 
             Homo sapiens 
           
            167
aucucacucu guggug                                                     16
 
           
             168 
             16 
             RNA 
             Homo sapiens 
           
            168
uggugguccu gcugac                                                     16
 
           
             169 
             16 
             RNA 
             Homo sapiens 
           
            169
ugguccugcu gacaaa                                                     16
 
           
             170 
             16 
             RNA 
             Homo sapiens 
           
            170
caagagcauu gcuuuu                                                     16
 
           
             171 
             16 
             RNA 
             Homo sapiens 
           
            171
cauugcuuuu guuucu                                                     16
 
           
             172 
             16 
             RNA 
             Homo sapiens 
           
            172
acuuuuaaau auuaac                                                     16
 
           
             173 
             16 
             RNA 
             Homo sapiens 
           
            173
cucaaaaguu gagauu                                                     16
 
           
             174 
             16 
             RNA 
             Homo sapiens 
           
            174
gggugguggu gugcca                                                     16
 
           
             175 
             16 
             RNA 
             Homo sapiens 
           
            175
gugguggugu gccaag                                                     16
 
           
             176 
             16 
             RNA 
             Homo sapiens 
           
            176
uuuaaacaau gaagug                                                     16
 
           
             177 
             16 
             RNA 
             Homo sapiens 
           
            177
acaaugaagu gaaaaa                                                     16
 
           
             178 
             16 
             RNA 
             Homo sapiens 
           
            178
aauuaacauu gcauaa                                                     16
 
           
             179 
             16 
             RNA 
             Homo sapiens 
           
            179
aacauugcau aaacac                                                     16
 
           
             180 
             16 
             RNA 
             Homo sapiens 
           
            180
uuucaagucu gaucca                                                     16
 
           
             181 
             16 
             RNA 
             Homo sapiens 
           
            181
ucugauccau auuuaa                                                     16
 
           
             182 
             16 
             RNA 
             Homo sapiens 
           
            182
cauauuuaau aaugcu                                                     16
 
           
             183 
             16 
             RNA 
             Homo sapiens 
           
            183
auuuaauaau gcuuua                                                     16
 
           
             184 
             16 
             RNA 
             Homo sapiens 
           
            184
gcuuuaaaau aaaaau                                                     16
 
           
             185 
             16 
             RNA 
             Homo sapiens 
           
            185
aaauaaaaau aaaaac                                                     16
 
           
             186 
             16 
             RNA 
             Homo sapiens 
           
            186
caauccuuuu gauaaa                                                     16
 
           
             187 
             16 
             RNA 
             Homo sapiens 
           
            187
uccuuuugau aaauuu                                                     16
 
           
             188 
             16 
             RNA 
             Homo sapiens 
           
            188
aauuuaaaau guuacu                                                     16
 
           
             189 
             16 
             RNA 
             Homo sapiens 
           
            189
auuuuaaaau aaauga                                                     16
 
           
             190 
             16 
             RNA 
             Homo sapiens 
           
            190
uaaaauaaau gaagug                                                     16
 
           
             191 
             16 
             RNA 
             Homo sapiens 
           
            191
uaaaugaagu gagaug                                                     16
 
           
             192 
             16 
             RNA 
             Homo sapiens 
           
            192
gaagugagau ggcaug                                                     16
 
           
             193 
             16 
             RNA 
             Homo sapiens 
           
            193
gagauggcau ggugag                                                     16
 
           
             194 
             16 
             RNA 
             Homo sapiens 
           
            194
auggcauggu gaggug                                                     16
 
           
             195 
             16 
             RNA 
             Homo sapiens 
           
            195
auggugaggu gaaagu                                                     16
 
           
             196 
             16 
             RNA 
             Homo sapiens 
           
            196
ggacuagguu guuggu                                                     16
 
           
             197 
             16 
             RNA 
             Homo sapiens 
           
            197
gguuguuggu gacuua                                                     16
 
           
             198 
             16 
             RNA 
             Homo sapiens 
           
            198
gguucuagau aggugu                                                     16
 
           
             199 
             16 
             RNA 
             Homo sapiens 
           
            199
cuagauaggu gucuuu                                                     16
 
           
             200 
             16 
             RNA 
             Homo sapiens 
           
            200
uuaggacucu gauuuu                                                     16
 
           
             201 
             16 
             RNA 
             Homo sapiens 
           
            201
cucugauuuu gaggac                                                     16
 
           
             202 
             16 
             RNA 
             Homo sapiens 
           
            202
auuucuucau guuaaa                                                     16
 
           
             203 
             16 
             RNA 
             Homo sapiens 
           
            203
uuuacacuau gugauu                                                     16
 
           
             204 
             16 
             RNA 
             Homo sapiens 
           
            204
uacacuaugu gauuua                                                     16
 
           
             205 
             16 
             RNA 
             Homo sapiens 
           
            205
ugugauuuau auucca                                                     16
 
           
             206 
             16 
             RNA 
             Homo sapiens 
           
            206
ccauuuacau aaggau                                                     16
 
           
             207 
             16 
             RNA 
             Homo sapiens 
           
            207
acauaaggau acacuu                                                     16
 
           
             208 
             16 
             RNA 
             Homo sapiens 
           
            208
acacuuauuu gucaag                                                     16
 
           
             209 
             16 
             RNA 
             Homo sapiens 
           
            209
agcacaaucu guaaau                                                     16
 
           
             210 
             16 
             RNA 
             Homo sapiens 
           
            210
uuuaaccuau guuaca                                                     16
 
           
             211 
             16 
             RNA 
             Homo sapiens 
           
            211
caucuucagu gccagu                                                     16
 
           
             212 
             16 
             RNA 
             Homo sapiens 
           
            212
gggcaaaauu gugcaa                                                     16
 
           
             213 
             16 
             RNA 
             Homo sapiens 
           
            213
gcaaaauugu gcaaga                                                     16
 
           
             214 
             16 
             RNA 
             Homo sapiens 
           
            214
ugcaagaggu gaaguu                                                     16
 
           
             215 
             16 
             RNA 
             Homo sapiens 
           
            215
ugaaguuuau auuuga                                                     16
 
           
             216 
             16 
             RNA 
             Homo sapiens 
           
            216
guuuauauuu gaauau                                                     16
 
           
             217 
             16 
             RNA 
             Homo sapiens 
           
            217
auauuugaau auccau                                                     16
 
           
             218 
             16 
             RNA 
             Homo sapiens 
           
            218
cuucuuccau auuagu                                                     16
 
           
             219 
             16 
             RNA 
             Homo sapiens 
           
            219
ccauauuagu gucauc                                                     16
 
           
             220 
             16 
             RNA 
             Homo sapiens 
           
            220
gugucaucuu gccucc                                                     16
 
           
             221 
             16 
             RNA 
             Homo sapiens 
           
            221
ccuuccacau gcccca                                                     16
 
           
             222 
             16 
             RNA 
             Homo sapiens 
           
            222
caugccccau gacuug                                                     16
 
           
             223 
             16 
             RNA 
             Homo sapiens 
           
            223
cccaugacuu gaugca                                                     16
 
           
             224 
             16 
             RNA 
             Homo sapiens 
           
            224
augacuugau gcaguu                                                     16
 
           
             225 
             16 
             RNA 
             Homo sapiens 
           
            225
caguuuuaau acuugu                                                     16
 
           
             226 
             16 
             RNA 
             Homo sapiens 
           
            226
uuuaauacuu guaauu                                                     16
 
           
             227 
             16 
             RNA 
             Homo sapiens 
           
            227
cccuaaccau aagauu                                                     16
 
           
             228 
             16 
             RNA 
             Homo sapiens 
           
            228
aagauuuacu gcugcu                                                     16
 
           
             229 
             16 
             RNA 
             Homo sapiens 
           
            229
auuuacugcu gcugug                                                     16
 
           
             230 
             16 
             RNA 
             Homo sapiens 
           
            230
uacugcugcu guggau                                                     16
 
           
             231 
             16 
             RNA 
             Homo sapiens 
           
            231
ugcuguggau aucucc                                                     16
 
           
             232 
             16 
             RNA 
             Homo sapiens 
           
            232
auaucuccau gaaguu                                                     16
 
           
             233 
             16 
             RNA 
             Homo sapiens 
           
            233
uuuucccacu gaguca                                                     16
 
           
             234 
             16 
             RNA 
             Homo sapiens 
           
            234
caucagaaau gcccua                                                     16
 
           
             235 
             16 
             RNA 
             Homo sapiens 
           
            235
aagagaaucu gacaga                                                     16
 
           
             236 
             16 
             RNA 
             Homo sapiens 
           
            236
ucugacagau accaua                                                     16
 
           
             237 
             16 
             RNA 
             Homo sapiens 
           
            237
cagauaccau aaaggg                                                     16
 
           
             238 
             16 
             RNA 
             Homo sapiens 
           
            238
aaagggauuu gaccua                                                     16
 
           
             239 
             16 
             RNA 
             Homo sapiens 
           
            239
ggugguggcu gaugcu                                                     16
 
           
             240 
             16 
             RNA 
             Homo sapiens 
           
            240
gguggcugau gcuuug                                                     16
 
           
             241 
             16 
             RNA 
             Homo sapiens 
           
            241
cugaugcuuu gaacau                                                     16
 
           
             242 
             16 
             RNA 
             Homo sapiens 
           
            242
acaucucuuu gcugcc                                                     16
 
           
             243 
             16 
             RNA 
             Homo sapiens 
           
            243
ucucuuugcu gcccaa                                                     16
 
           
             244 
             16 
             RNA 
             Homo sapiens 
           
            244
auccauuagc gacagu                                                     16
 
           
             245 
             16 
             RNA 
             Homo sapiens 
           
            245
acccugguau gaauag                                                     16
 
           
             246 
             16 
             RNA 
             Homo sapiens 
           
            246
ugguaugaau agacag                                                     16
 
           
             247 
             16 
             RNA 
             Homo sapiens 
           
            247
agaauuuaau aaagau                                                     16
 
           
             248 
             16 
             RNA 
             Homo sapiens 
           
            248
uaauaaagau agugca                                                     16
 
           
             249 
             16 
             RNA 
             Homo sapiens 
           
            249
uaaagauagu gcagaa                                                     16
 
           
             250 
             16 
             RNA 
             Homo sapiens 
           
            250
gguaaucuau aacuag                                                     16
 
           
             251 
             16 
             RNA 
             Homo sapiens 
           
            251
uaacaguaau acauuc                                                     16
 
           
             252 
             16 
             RNA 
             Homo sapiens 
           
            252
acauuccauu guuuua                                                     16
 
           
             253 
             16 
             RNA 
             Homo sapiens 
           
            253
aaaucuucau gcaaug                                                     16
 
           
             254 
             16 
             RNA 
             Homo sapiens 
           
            254
uucaugcaau gaaaaa                                                     16
 
           
             255 
             16 
             RNA 
             Homo sapiens 
           
            255
aaugaaaaau acuuua                                                     16
 
           
             256 
             16 
             RNA 
             Homo sapiens 
           
            256
uuuaauucau gaagcu                                                     16
 
           
             257 
             16 
             RNA 
             Homo sapiens 
           
            257
uuuuuuuggu gucaga                                                     16
 
           
             258 
             16 
             RNA 
             Homo sapiens 
           
            258
ucagagucuc gcucuu                                                     16
 
           
             259 
             16 
             RNA 
             Homo sapiens 
           
            259
ucucgcucuu gucacc                                                     16
 
           
             260 
             16 
             RNA 
             Homo sapiens 
           
            260
aggcuggaau gcagug                                                     16
 
           
             261 
             16 
             RNA 
             Homo sapiens 
           
            261
augcaguggc gccauc                                                     16
 
           
             262 
             16 
             RNA 
             Homo sapiens 
           
            262
ucagcucacu gcaacc                                                     16
 
           
             263 
             16 
             RNA 
             Homo sapiens 
           
            263
agguucaagc gauucu                                                     16
 
           
             264 
             16 
             RNA 
             Homo sapiens 
           
            264
cgauucucgu gccucg                                                     16
 
           
             265 
             16 
             RNA 
             Homo sapiens 
           
            265
ucggccuccu gaguag                                                     16
 
           
             266 
             16 
             RNA 
             Homo sapiens 
           
            266
uuacaggcgu gugcac                                                     16
 
           
             267 
             16 
             RNA 
             Homo sapiens 
           
            267
acaggcgugu gcacua                                                     16
 
           
             268 
             16 
             RNA 
             Homo sapiens 
           
            268
acuaauuuuu guauuu                                                     16
 
           
             269 
             16 
             RNA 
             Homo sapiens 
           
            269
gguuucaccu guuggc                                                     16
 
           
             270 
             16 
             RNA 
             Homo sapiens 
           
            270
ggcuggucuc gaacuc                                                     16
 
           
             271 
             16 
             RNA 
             Homo sapiens 
           
            271
ucgaacuccu gaccuc                                                     16
 
           
             272 
             16 
             RNA 
             Homo sapiens 
           
            272
gaccucaagu gauuca                                                     16
 
           
             273 
             16 
             RNA 
             Homo sapiens 
           
            273
uuggccucau aaaccu                                                     16
 
           
             274 
             16 
             RNA 
             Homo sapiens 
           
            274
ucauaaaccu guuuug                                                     16
 
           
             275 
             16 
             RNA 
             Homo sapiens 
           
            275
aaccuguuuu gcagaa                                                     16
 
           
             276 
             16 
             RNA 
             Homo sapiens 
           
            276
uucagcaaau auuuau                                                     16
 
           
             277 
             16 
             RNA 
             Homo sapiens 
           
            277
aauauuuauu gagugc                                                     16
 
           
             278 
             16 
             RNA 
             Homo sapiens 
           
            278
uuuauugagu gccuac                                                     16
 
           
             279 
             16 
             RNA 
             Homo sapiens 
           
            279
ccuaccagau gccagu                                                     16
 
           
             280 
             16 
             RNA 
             Homo sapiens 
           
            280
gccagucacc gcacaa                                                     16
 
           
             281 
             16 
             RNA 
             Homo sapiens 
           
            281
cacuggguau auggua                                                     16
 
           
             282 
             16 
             RNA 
             Homo sapiens 
           
            282
cuggguauau gguauc                                                     16
 
           
             283 
             16 
             RNA 
             Homo sapiens 
           
            283
caagagacau aauccc                                                     16
 
           
             284 
             16 
             RNA 
             Homo sapiens 
           
            284
cuuagguacu gcuagu                                                     16
 
           
             285 
             16 
             RNA 
             Homo sapiens 
           
            285
uacugcuagu gugguc                                                     16
 
           
             286 
             16 
             RNA 
             Homo sapiens 
           
            286
aguguggucu guaaua                                                     16
 
           
             287 
             16 
             RNA 
             Homo sapiens 
           
            287
ggucuguaau aucuua                                                     16
 
           
             288 
             16 
             RNA 
             Homo sapiens 
           
            288
ccuuugguau acgacc                                                     16
 
           
             289 
             16 
             RNA 
             Homo sapiens 
           
            289
uuugguauac gaccca                                                     16
 
           
             290 
             16 
             RNA 
             Homo sapiens 
           
            290
acccagagau aacacg                                                     16
 
           
             291 
             16 
             RNA 
             Homo sapiens 
           
            291
gagauaacac gaugcg                                                     16
 
           
             292 
             16 
             RNA 
             Homo sapiens 
           
            292
auaacacgau gcguau                                                     16
 
           
             293 
             16 
             RNA 
             Homo sapiens 
           
            293
uuuuaguuuu gcaaag                                                     16
 
           
             294 
             16 
             RNA 
             Homo sapiens 
           
            294
uuuggucucu gugcca                                                     16
 
           
             295 
             16 
             RNA 
             Homo sapiens 
           
            295
uggucucugu gccagc                                                     16
 
           
             296 
             16 
             RNA 
             Homo sapiens 
           
            296
ccagcucuau aauugu                                                     16
 
           
             297 
             16 
             RNA 
             Homo sapiens 
           
            297
cucuauaauu guuuug                                                     16
 
           
             298 
             16 
             RNA 
             Homo sapiens 
           
            298
uaauuguuuu gcuacg                                                     16
 
           
             299 
             16 
             RNA 
             Homo sapiens 
           
            299
guuuugcuac gauucc                                                     16
 
           
             300 
             16 
             RNA 
             Homo sapiens 
           
            300
cgauuccacu gaaacu                                                     16
 
           
             301 
             16 
             RNA 
             Homo sapiens 
           
            301
gaaacucuuc gaucaa                                                     16
 
           
             302 
             16 
             RNA 
             Homo sapiens 
           
            302
gcuacuuuau guaaau                                                     16
 
           
             303 
             16 
             RNA 
             Homo sapiens 
           
            303
ucacuucauu guuuua                                                     16
 
           
             304 
             16 
             RNA 
             Homo sapiens 
           
            304
uuaaaggaau aaacuu                                                     16
 
           
             305 
             16 
             RNA 
             Homo sapiens 
           
            305
gaauaaacuu gauuau                                                     16
 
           
             306 
             16 
             RNA 
             Homo sapiens 
           
            306
acuugauuau auuguu                                                     16
 
           
             307 
             16 
             RNA 
             Homo sapiens 
           
            307
ugauuauauu guuuuu                                                     16
 
           
             308 
             16 
             RNA 
             Homo sapiens 
           
            308
uauuuggcau aacugu                                                     16
 
           
             309 
             16 
             RNA 
             Homo sapiens 
           
            309
uggcauaacu gugauu                                                     16
 
           
             310 
             16 
             RNA 
             Homo sapiens 
           
            310
gcauaacugu gauucu                                                     16
 
           
             311 
             16 
             RNA 
             Homo sapiens 
           
            311
gacaauuacu guacac                                                     16
 
           
             312 
             16 
             RNA 
             Homo sapiens 
           
            312
acauuaaggu guaugu                                                     16
 
           
             313 
             16 
             RNA 
             Homo sapiens 
           
            313
uaagguguau gucaga                                                     16
 
           
             314 
             16 
             RNA 
             Homo sapiens 
           
            314
uaugucagau auucau                                                     16
 
           
             315 
             16 
             RNA 
             Homo sapiens 
           
            315
agauauucau auugac                                                     16
 
           
             316 
             16 
             RNA 
             Homo sapiens 
           
            316
uauucauauu gaccca                                                     16
 
           
             317 
             16 
             RNA 
             Homo sapiens 
           
            317
ugacccaaau guguaa                                                     16
 
           
             318 
             16 
             RNA 
             Homo sapiens 
           
            318
acccaaaugu guaaua                                                     16
 
           
             319 
             16 
             RNA 
             Homo sapiens 
           
            319
aauguguaau auucca                                                     16
 
           
             320 
             16 
             RNA 
             Homo sapiens 
           
            320
aguuuucucu gcauaa                                                     16
 
           
             321 
             16 
             RNA 
             Homo sapiens 
           
            321
uucucugcau aaguaa                                                     16
 
           
             322 
             16 
             RNA 
             Homo sapiens 
           
            322
uaauuaaaau auacuu                                                     16
 
           
             323 
             16 
             RNA 
             Homo sapiens 
           
            323
auuaaaauau acuuaa                                                     16
 
           
             324 
             16 
             RNA 
             Homo sapiens 
           
            324
aaaaauuaau aguuuu                                                     16
 
           
             325 
             16 
             RNA 
             Homo sapiens 
           
            325
ggguacaaau aaacag                                                     16
 
           
             326 
             16 
             RNA 
             Homo sapiens 
           
            326
aauaaacagu gccuga                                                     16
 
           
             327 
             16 
             RNA 
             Homo sapiens 
           
            327
aacagugccu gaacua                                                     16
 
           
             328 
             16 
             RNA 
             Homo sapiens 
           
            328
aaacuucuau guaaaa                                                     16
 
           
             329 
             16 
             RNA 
             Homo sapiens 
           
            329
aaaucacuau gauuuc                                                     16
 
           
             330 
             16 
             RNA 
             Homo sapiens 
           
            330
uaugauuucu gaauug                                                     16
 
           
             331 
             16 
             RNA 
             Homo sapiens 
           
            331
uuucugaauu gcuaug                                                     16
 
           
             332 
             16 
             RNA 
             Homo sapiens 
           
            332
gaauugcuau gugaaa                                                     16
 
           
             333 
             16 
             RNA 
             Homo sapiens 
           
            333
auugcuaugu gaaacu                                                     16
 
           
             334 
             16 
             RNA 
             Homo sapiens 
           
            334
uuggaacacu guuuag                                                     16
 
           
             335 
             16 
             RNA 
             Homo sapiens 
           
            335
uagguagggu guuaag                                                     16
 
           
             336 
             16 
             RNA 
             Homo sapiens 
           
            336
guuaagacuu gacaca                                                     16
 
           
             337 
             16 
             RNA 
             Homo sapiens 
           
            337
agaaagaaau ggccau                                                     16
 
           
             338 
             16 
             RNA 
             Homo sapiens 
           
            338
aaauggccau acuuca                                                     16
 
           
             339 
             16 
             RNA 
             Homo sapiens 
           
            339
uucaggaacu gcagug                                                     16
 
           
             340 
             16 
             RNA 
             Homo sapiens 
           
            340
gaacugcagu gcuuau                                                     16
 
           
             341 
             16 
             RNA 
             Homo sapiens 
           
            341
cagugcuuau gagggg                                                     16
 
           
             342 
             16 
             RNA 
             Homo sapiens 
           
            342
augaggggau auuuag                                                     16
 
           
             343 
             16 
             RNA 
             Homo sapiens 
           
            343
uaggccucuu gaauuu                                                     16
 
           
             344 
             16 
             RNA 
             Homo sapiens 
           
            344
uugaauuuuu gaugua                                                     16
 
           
             345 
             16 
             RNA 
             Homo sapiens 
           
            345
aauuuuugau guagau                                                     16
 
           
             346 
             16 
             RNA 
             Homo sapiens 
           
            346
ugauguagau gggcau                                                     16
 
           
             347 
             16 
             RNA 
             Homo sapiens 
           
            347
uuaccuuuau gugaac                                                     16
 
           
             348 
             16 
             RNA 
             Homo sapiens 
           
            348
accuuuaugu gaacuu                                                     16
 
           
             349 
             16 
             RNA 
             Homo sapiens 
           
            349
ugugaacuuu gaaugg                                                     16
 
           
             350 
             16 
             RNA 
             Homo sapiens 
           
            350
aacuuugaau gguuua                                                     16
 
           
             351 
             16 
             RNA 
             Homo sapiens 
           
            351
caaaagauuu guuuuu                                                     16
 
           
             352 
             16 
             RNA 
             Homo sapiens 
           
            352
auuuguuuuu guagag                                                     16
 
           
             353 
             16 
             RNA 
             Homo sapiens 
           
            353
uucuagaaau aaaugu                                                     16
 
           
             354 
             16 
             RNA 
             Homo sapiens 
           
            354
agaaauaaau guuacc                                                     16
 
           
             355 
             16 
             RNA 
             Homo sapiens 
           
            355
aaaaauccuu guugaa                                                     16
 
           
             356 
             16 
             RNA 
             Homo sapiens 
           
            356
aauccuuguu gaaguu                                                     16
 
           
             357 
             16 
             RNA 
             Homo sapiens 
           
            357
uaaauuacau agacuu                                                     16
 
           
             358 
             16 
             RNA 
             Homo sapiens 
           
            358
gcauuaacau guuugu                                                     16
 
           
             359 
             16 
             RNA 
             Homo sapiens 
           
            359
uaacauguuu guggaa                                                     16
 
           
             360 
             16 
             RNA 
             Homo sapiens 
           
            360
guggaagaau auagca                                                     16
 
           
             361 
             16 
             RNA 
             Homo sapiens 
           
            361
ggaagaauau agcaga                                                     16
 
           
             362 
             16 
             RNA 
             Homo sapiens 
           
            362
gcagacguau auugua                                                     16
 
           
             363 
             16 
             RNA 
             Homo sapiens 
           
            363
gacguauauu guauca                                                     16
 
           
             364 
             16 
             RNA 
             Homo sapiens 
           
            364
uguaucauuu gaguga                                                     16
 
           
             365 
             16 
             RNA 
             Homo sapiens 
           
            365
ucauuugagu gaaugu                                                     16
 
           
             366 
             16 
             RNA 
             Homo sapiens 
           
            366
uugagugaau guuccc                                                     16
 
           
             367 
             16 
             RNA 
             Homo sapiens 
           
            367
cuauuuaacu gaguca                                                     16
 
           
             368 
             16 
             RNA 
             Homo sapiens 
           
            368
gagucacacu gcauag                                                     16
 
           
             369 
             16 
             RNA 
             Homo sapiens 
           
            369
cacacugcau aggaau                                                     16
 
           
             370 
             16 
             RNA 
             Homo sapiens 
           
            370
uaacuuuuau agguua                                                     16
 
           
             371 
             16 
             RNA 
             Homo sapiens 
           
            371
uaucaaaacu guuguc                                                     16
 
           
             372 
             16 
             RNA 
             Homo sapiens 
           
            372
caaaacuguu gucacc                                                     16
 
           
             373 
             16 
             RNA 
             Homo sapiens 
           
            373
ugucaccauu gcacaa                                                     16
 
           
             374 
             16 
             RNA 
             Homo sapiens 
           
            374
gcacaauuuu guccua                                                     16
 
           
             375 
             16 
             RNA 
             Homo sapiens 
           
            375
uuguccuaau auauac                                                     16
 
           
             376 
             16 
             RNA 
             Homo sapiens 
           
            376
guccuaauau auacau                                                     16
 
           
             377 
             16 
             RNA 
             Homo sapiens 
           
            377
ccuaauauau acauag                                                     16
 
           
             378 
             16 
             RNA 
             Homo sapiens 
           
            378
auauauacau agaaac                                                     16
 
           
             379 
             16 
             RNA 
             Homo sapiens 
           
            379
uagaaacuuu gugggg                                                     16
 
           
             380 
             16 
             RNA 
             Homo sapiens 
           
            380
uguggggcau guuaag                                                     16
 
           
             381 
             16 
             RNA 
             Homo sapiens 
           
            381
guuacaguuu gcacaa                                                     16
 
           
             382 
             16 
             RNA 
             Homo sapiens 
           
            382
caucucauuu guauuc                                                     16
 
           
             383 
             16 
             RNA 
             Homo sapiens 
           
            383
guauuccauu gauuuu                                                     16
 
           
             384 
             16 
             RNA 
             Homo sapiens 
           
            384
aaaacaguau auauaa                                                     16
 
           
             385 
             16 
             RNA 
             Homo sapiens 
           
            385
aacaguauau auaacu                                                     16
 
           
             386 
             16 
             RNA 
             Homo sapiens 
           
            386
caguauauau aacuuu                                                     16
 
           
             387 
             16 
             RNA 
             Homo sapiens 
           
            387
aaaacuaucu gaagau                                                     16
 
           
             388 
             16 
             RNA 
             Homo sapiens 
           
            388
auuuccauuu gucaaa                                                     16
 
           
             389 
             16 
             RNA 
             Homo sapiens 
           
            389
aaaaaguaau gauuuc                                                     16
 
           
             390 
             16 
             RNA 
             Homo sapiens 
           
            390
augauuucuu gauaau                                                     16
 
           
             391 
             16 
             RNA 
             Homo sapiens 
           
            391
auuucuugau aauugu                                                     16
 
           
             392 
             16 
             RNA 
             Homo sapiens 
           
            392
cuugauaauu guguag                                                     16
 
           
             393 
             16 
             RNA 
             Homo sapiens 
           
            393
ugauaauugu guagug                                                     16
 
           
             394 
             16 
             RNA 
             Homo sapiens 
           
            394
auuguguagu gaaugu                                                     16
 
           
             395 
             16 
             RNA 
             Homo sapiens 
           
            395
uguagugaau guuuuu                                                     16
 
           
             396 
             16 
             RNA 
             Homo sapiens 
           
            396
caguuaccuu gaaagc                                                     16
 
           
             397 
             16 
             RNA 
             Homo sapiens 
           
            397
cuugaaagcu gaauuu                                                     16
 
           
             398 
             16 
             RNA 
             Homo sapiens 
           
            398
cugaauuuau auuuag                                                     16
 
           
             399 
             16 
             RNA 
             Homo sapiens 
           
            399
aguaacuucu guguua                                                     16
 
           
             400 
             16 
             RNA 
             Homo sapiens 
           
            400
uaacuucugu guuaau                                                     16
 
           
             401 
             16 
             RNA 
             Homo sapiens 
           
            401
cuguguuaau acugga                                                     16
 
           
             402 
             16 
             RNA 
             Homo sapiens 
           
            402
aauacuggau agcaug                                                     16
 
           
             403 
             16 
             RNA 
             Homo sapiens 
           
            403
uggauagcau gaauuc                                                     16
 
           
             404 
             16 
             RNA 
             Homo sapiens 
           
            404
caugaauucu gcauug                                                     16
 
           
             405 
             16 
             RNA 
             Homo sapiens 
           
            405
auucugcauu gagaaa                                                     16
 
           
             406 
             16 
             RNA 
             Homo sapiens 
           
            406
uugagaaacu gaauag                                                     16
 
           
             407 
             16 
             RNA 
             Homo sapiens 
           
            407
gaaacugaau agcugu                                                     16
 
           
             408 
             16 
             RNA 
             Homo sapiens 
           
            408
cugaauagcu gucaua                                                     16
 
           
             409 
             16 
             RNA 
             Homo sapiens 
           
            409
uagcugucau aaaaug                                                     16
 
           
             410 
             16 
             RNA 
             Homo sapiens 
           
            410
gucauaaaau gcuuuc                                                     16
 
           
             411 
             16 
             RNA 
             Homo sapiens 
           
            411
aaagaaagau acucac                                                     16
 
           
             412 
             16 
             RNA 
             Homo sapiens 
           
            412
auacucacau gaguuc                                                     16
 
           
             413 
             16 
             RNA 
             Homo sapiens 
           
            413
augaguucuu gaagaa                                                     16
 
           
             414 
             16 
             RNA 
             Homo sapiens 
           
            414
cuugaagaau agucau                                                     16
 
           
             415 
             16 
             RNA 
             Homo sapiens 
           
            415
gaauagucau aacuag                                                     16
 
           
             416 
             16 
             RNA 
             Homo sapiens 
           
            416
auuaagaucu guguuu                                                     16
 
           
             417 
             16 
             RNA 
             Homo sapiens 
           
            417
uaagaucugu guuuua                                                     16
 
           
             418 
             16 
             RNA 
             Homo sapiens 
           
            418
uuaguuuaau aguuug                                                     16
 
           
             419 
             16 
             RNA 
             Homo sapiens 
           
            419
uuaauaguuu gaagug                                                     16
 
           
             420 
             16 
             RNA 
             Homo sapiens 
           
            420
aguuugaagu gccugu                                                     16
 
           
             421 
             16 
             RNA 
             Homo sapiens 
           
            421
ugaagugccu guuugg                                                     16
 
           
             422 
             16 
             RNA 
             Homo sapiens 
           
            422
uguuugggau aaugau                                                     16
 
           
             423 
             16 
             RNA 
             Homo sapiens 
           
            423
uugggauaau gauagg                                                     16
 
           
             424 
             16 
             RNA 
             Homo sapiens 
           
            424
ggauaaugau agguaa                                                     16
 
           
             425 
             16 
             RNA 
             Homo sapiens 
           
            425
uaauuuagau gaauuu                                                     16
 
           
             426 
             16 
             RNA 
             Homo sapiens 
           
            426
aaaguuaucu gcaguu                                                     16
 
           
             427 
             16 
             RNA 
             Homo sapiens 
           
            427
cugcaguuau guugag                                                     16
 
           
             428 
             16 
             RNA 
             Homo sapiens 
           
            428
caguuauguu gagggc                                                     16
 
           
             429 
             16 
             RNA 
             Homo sapiens 
           
            429
ggguuacagu guuuua                                                     16
 
           
             430 
             16 
             RNA 
             Homo sapiens 
           
            430
uguuuuaucc gaaagu                                                     16
 
           
             431 
             16 
             RNA 
             Homo sapiens 
           
            431
caauuccacu gucuug                                                     16
 
           
             432 
             16 
             RNA 
             Homo sapiens 
           
            432
ccacugucuu guguuu                                                     16
 
           
             433 
             16 
             RNA 
             Homo sapiens 
           
            433
acugucuugu guuuuc                                                     16
 
           
             434 
             16 
             RNA 
             Homo sapiens 
           
            434
guguuuucau guugaa                                                     16
 
           
             435 
             16 
             RNA 
             Homo sapiens 
           
            435
uuuucauguu gaaaau                                                     16
 
           
             436 
             16 
             RNA 
             Homo sapiens 
           
            436
uguugaaaau acuuuu                                                     16
 
           
             437 
             16 
             RNA 
             Homo sapiens 
           
            437
aaauacuuuu gcauuu                                                     16
 
           
             438 
             16 
             RNA 
             Homo sapiens 
           
            438
uuuuuccuuu gagugc                                                     16
 
           
             439 
             16 
             RNA 
             Homo sapiens 
           
            439
uccuuugagu gccaau                                                     16
 
           
             440 
             16 
             RNA 
             Homo sapiens 
           
            440
auuucuuaau guaaca                                                     16
 
           
             441 
             16 
             RNA 
             Homo sapiens 
           
            441
aauguaacau guuuac                                                     16
 
           
             442 
             16 
             RNA 
             Homo sapiens 
           
            442
uaccuggccu gucuuu                                                     16
 
           
             443 
             16 
             RNA 
             Homo sapiens 
           
            443
aacuauuuuu guauag                                                     16
 
           
             444 
             16 
             RNA 
             Homo sapiens 
           
            444
auuuuuguau agugua                                                     16
 
           
             445 
             16 
             RNA 
             Homo sapiens 
           
            445
uuuguauagu guaaac                                                     16
 
           
             446 
             16 
             RNA 
             Homo sapiens 
           
            446
aguguaaacu gaaaca                                                     16
 
           
             447 
             16 
             RNA 
             Homo sapiens 
           
            447
acugaaacau gcacau                                                     16
 
           
             448 
             16 
             RNA 
             Homo sapiens 
           
            448
ugcacauuuu guacau                                                     16
 
           
             449 
             16 
             RNA 
             Homo sapiens 
           
            449
uuuguacauu gugcuu                                                     16
 
           
             450 
             16 
             RNA 
             Homo sapiens 
           
            450
uguacauugu gcuuuc                                                     16
 
           
             451 
             16 
             RNA 
             Homo sapiens 
           
            451
gcuuucuuuu gugggu                                                     16
 
           
             452 
             16 
             RNA 
             Homo sapiens 
           
            452
ugugggucau augcag                                                     16
 
           
             453 
             16 
             RNA 
             Homo sapiens 
           
            453
ugggucauau gcagug                                                     16
 
           
             454 
             16 
             RNA 
             Homo sapiens 
           
            454
cauaugcagu gugauc                                                     16
 
           
             455 
             16 
             RNA 
             Homo sapiens 
           
            455
uaugcagugu gaucca                                                     16
 
           
             456 
             16 
             RNA 
             Homo sapiens 
           
            456
ugauccaguu guuuuc                                                     16
 
           
             457 
             16 
             RNA 
             Homo sapiens 
           
            457
ucauuugguu gcgcug                                                     16
 
           
             458 
             16 
             RNA 
             Homo sapiens 
           
            458
auuugguugc gcugac                                                     16
 
           
             459 
             16 
             RNA 
             Homo sapiens 
           
            459
ugguugcgcu gaccua                                                     16
 
           
             460 
             16 
             RNA 
             Homo sapiens 
           
            460
accuaggaau guuggu                                                     16
 
           
             461 
             16 
             RNA 
             Homo sapiens 
           
            461
uguuggucau aucaaa                                                     16
 
           
             462 
             16 
             RNA 
             Homo sapiens 
           
            462
cauuaaaaau gaccac                                                     16
 
           
             463 
             16 
             RNA 
             Homo sapiens 
           
            463
cucuuuuaau gaaauu                                                     16
 
           
             464 
             16 
             RNA 
             Homo sapiens 
           
            464
acuuuuaaau guuuau                                                     16
 
           
             465 
             16 
             RNA 
             Homo sapiens 
           
            465
aaauguuuau aggagu                                                     16
 
           
             466 
             16 
             RNA 
             Homo sapiens 
           
            466
auaggaguau gugcug                                                     16
 
           
             467 
             16 
             RNA 
             Homo sapiens 
           
            467
aggaguaugu gcugug                                                     16
 
           
             468 
             16 
             RNA 
             Homo sapiens 
           
            468
aguaugugcu gugaag                                                     16
 
           
             469 
             16 
             RNA 
             Homo sapiens 
           
            469
uaugugcugu gaagug                                                     16
 
           
             470 
             16 
             RNA 
             Homo sapiens 
           
            470
gcugugaagu gaucua                                                     16
 
           
             471 
             16 
             RNA 
             Homo sapiens 
           
            471
ucuaaaauuu guaaua                                                     16
 
           
             472 
             16 
             RNA 
             Homo sapiens 
           
            472
aauuuguaau auuuuu                                                     16
 
           
             473 
             16 
             RNA 
             Homo sapiens 
           
            473
uaauauuuuu gucaug                                                     16
 
           
             474 
             16 
             RNA 
             Homo sapiens 
           
            474
uuuuugucau gaacug                                                     16
 
           
             475 
             16 
             RNA 
             Homo sapiens 
           
            475
gucaugaacu guacua                                                     16
 
           
             476 
             16 
             RNA 
             Homo sapiens 
           
            476
ccuaauuauu guaaug                                                     16
 
           
             477 
             16 
             RNA 
             Homo sapiens 
           
            477
uuauuguaau guaaua                                                     16
 
           
             478 
             16 
             RNA 
             Homo sapiens 
           
            478
guaauguaau aaaaau                                                     16
 
           
             479 
             16 
             RNA 
             Homo sapiens 
           
            479
uaauaaaaau aguuac                                                     16
 
           
             480 
             16 
             RNA 
             Homo sapiens 
           
            480
uaguuacagu gacuau                                                     16
 
           
             481 
             16 
             RNA 
             Homo sapiens 
           
            481
cagugacuau gagugu                                                     16
 
           
             482 
             16 
             RNA 
             Homo sapiens 
           
            482
gacuaugagu guguau                                                     16
 
           
             483 
             16 
             RNA 
             Homo sapiens 
           
            483
cuaugagugu guauuu                                                     16
 
           
             484 
             16 
             RNA 
             Homo sapiens 
           
            484
auuuauucau gcaaau                                                     16
 
           
             485 
             16 
             RNA 
             Homo sapiens 
           
            485
augcaaauuu gaacug                                                     16
 
           
             486 
             16 
             RNA 
             Homo sapiens 
           
            486
aauuugaacu guuugc                                                     16
 
           
             487 
             16 
             RNA 
             Homo sapiens 
           
            487
ugaacuguuu gccccg                                                     16
 
           
             488 
             16 
             RNA 
             Homo sapiens 
           
            488
uguuugcccc gaaaug                                                     16
 
           
             489 
             16 
             RNA 
             Homo sapiens 
           
            489
gccccgaaau ggauau                                                     16
 
           
             490 
             16 
             RNA 
             Homo sapiens 
           
            490
cgaaauggau auggau                                                     16
 
           
             491 
             16 
             RNA 
             Homo sapiens 
           
            491
aaauggauau ggauac                                                     16
 
           
             492 
             16 
             RNA 
             Homo sapiens 
           
            492
ggauauggau acuuua                                                     16
 
           
             493 
             16 
             RNA 
             Homo sapiens 
           
            493
gauacuuuau aagcca                                                     16
 
           
             494 
             16 
             RNA 
             Homo sapiens 
           
            494
uauaagccau agacac                                                     16
 
           
             495 
             16 
             RNA 
             Homo sapiens 
           
            495
uagacacuau aguaua                                                     16
 
           
             496 
             16 
             RNA 
             Homo sapiens 
           
            496
acuauaguau accagu                                                     16
 
           
             497 
             16 
             RNA 
             Homo sapiens 
           
            497
guauaccagu gaaucu                                                     16
 
           
             498 
             16 
             RNA 
             Homo sapiens 
           
            498
aaucuuuuau gcagcu                                                     16
 
           
             499 
             16 
             RNA 
             Homo sapiens 
           
            499
uaugcagcuu guuaga                                                     16
 
           
             500 
             16 
             RNA 
             Homo sapiens 
           
            500
ucuaaaaggu gcugug                                                     16
 
           
             501 
             16 
             RNA 
             Homo sapiens 
           
            501
aaaaggugcu guggau                                                     16
 
           
             502 
             16 
             RNA 
             Homo sapiens 
           
            502
ugcuguggau auuaug                                                     16
 
           
             503 
             16 
             RNA 
             Homo sapiens 
           
            503
uggauauuau guaaag                                                     16
 
           
             504 
             16 
             RNA 
             Homo sapiens 
           
            504
guaaaggcgu guuugc                                                     16
 
           
             505 
             16 
             RNA 
             Homo sapiens 
           
            505
aggcguguuu gcuuaa                                                     16
 
           
             506 
             16 
             RNA 
             Homo sapiens 
           
            506
aauuuuccau auuuag                                                     16
 
           
             507 
             16 
             RNA 
             Homo sapiens 
           
            507
agaaguagau gcaaaa                                                     16
 
           
             508 
             16 
             RNA 
             Homo sapiens 
           
            508
aaacaaaucu gccuuu                                                     16
 
           
             509 
             16 
             RNA 
             Homo sapiens 
           
            509
cugccuuuau gacaaa                                                     16
 
           
             510 
             16 
             RNA 
             Homo sapiens 
           
            510
acaaaaaaau aggaua                                                     16
 
           
             511 
             16 
             RNA 
             Homo sapiens 
           
            511
aaaauaggau aacauu                                                     16
 
           
             512 
             16 
             RNA 
             Homo sapiens 
           
            512
uuuuaucaau aaggua                                                     16
 
           
             513 
             16 
             RNA 
             Homo sapiens 
           
            513
uaagguaauu gauaca                                                     16
 
           
             514 
             16 
             RNA 
             Homo sapiens 
           
            514
gguaauugau acacaa                                                     16
 
           
             515 
             16 
             RNA 
             Homo sapiens 
           
            515
cacaacaggu gacuug                                                     16
 
           
             516 
             16 
             RNA 
             Homo sapiens 
           
            516
caacauuaau aaugga                                                     16
 
           
             517 
             16 
             RNA 
             Homo sapiens 
           
            517
cauuaauaau ggaaau                                                     16
 
           
             518 
             16 
             RNA 
             Homo sapiens 
           
            518
uaauggaaau aauuga                                                     16
 
           
             519 
             16 
             RNA 
             Homo sapiens 
           
            519
ggaaauaauu gaauag                                                     16
 
           
             520 
             16 
             RNA 
             Homo sapiens 
           
            520
auaauugaau aguuag                                                     16
 
           
             521 
             16 
             RNA 
             Homo sapiens 
           
            521
aguuaguuau guaugu                                                     16
 
           
             522 
             16 
             RNA 
             Homo sapiens 
           
            522
aguuauguau guuaau                                                     16
 
           
             523 
             16 
             RNA 
             Homo sapiens 
           
            523
guauguuaau gccagu                                                     16
 
           
             524 
             16 
             RNA 
             Homo sapiens 
           
            524
cagaaguaau gacucc                                                     16
 
           
             525 
             16 
             RNA 
             Homo sapiens 
           
            525
augacuccau acauau                                                     16
 
           
             526 
             16 
             RNA 
             Homo sapiens 
           
            526
cuccauacau auuauu                                                     16
 
           
             527 
             16 
             RNA 
             Homo sapiens 
           
            527
uuauuucuau aacuac                                                     16
 
           
             528 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            528
cgccgugaug gcaugcacua ugcgcgggcc gccgcc                               36
 
           
             529 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            529
accuuugaug gcaugcacua ugcgcggccg ccgcca                               36
 
           
             530 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            530
aauggugaug gcaugcacua ugcgcggggg gccggg                               36
 
           
             531 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            531
gcgcuugaug gcaugcacua ugcgcggcuc ccaguc                               36
 
           
             532 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            532
cgccgugaug gcaugcacua ugcgcggcuc gcuccc                               36
 
           
             533 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            533
gccugugaug gcaugcacua ugcgcggccg cgcucg                               36
 
           
             534 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            534
gccuuugaug gcaugcacua ugcgcgagug ccugcg                               36
 
           
             535 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            535
ucccgugaug gcaugcacua ugcgcgaccu gggagc                               36
 
           
             536 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            536
uucagugaug gcaugcacua ugcgcgaggc cucucu                               36
 
           
             537 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            537
auuuuugaug gcaugcacua ugcgcgagca ggccuc                               36
 
           
             538 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            538
ucaguugaug gcaugcacua ugcgcgauuu ucagca                               36
 
           
             539 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            539
auauuugaug gcaugcacua ugcgcgaguc auuuuc                               36
 
           
             540 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            540
guuuaugaug gcaugcacua ugcgcgauuc agucau                               36
 
           
             541 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            541
aaguuugaug gcaugcacua ugcgcgauau ucaguc                               36
 
           
             542 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            542
uaccaugaug gcaugcacua ugcgcgaagu uuauau                               36
 
           
             543 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            543
cgccaugaug gcaugcacua ugcgcgaagc uccaac                               36
 
           
             544 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            544
caaggugaug gcaugcacua ugcgcgacuc uugccu                               36
 
           
             545 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            545
aucguugaug gcaugcacua ugcgcgaagg cacucu                               36
 
           
             546 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            546
uguauugaug gcaugcacua ugcgcgguca aggcac                               36
 
           
             547 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            547
agcugugaug gcaugcacua ugcgcgaucg ucaagg                               36
 
           
             548 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            548
guccaugaug gcaugcacua ugcgcgaaaa ugauuc                               36
 
           
             549 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            549
auauuugaug gcaugcacua ugcgcggucc acaaaa                               36
 
           
             550 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            550
gaucaugaug gcaugcacua ugcgcgauuc guccac                               36
 
           
             551 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            551
uggauugaug gcaugcacua ugcgcgauau ucgucc                               36
 
           
             552 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            552
uccucugaug gcaugcacua ugcgcgauug uuggau                               36
 
           
             553 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            553
uccauugaug gcaugcacua ugcgcgaauu acuacu                               36
 
           
             554 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            554
uucucugaug gcaugcacua ugcgcgauca auuacu                               36
 
           
             555 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            555
agagaugaug gcaugcacua ugcgcgaggu uucucc                               36
 
           
             556 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            556
gagaaugaug gcaugcacua ugcgcgaucc aagaga                               36
 
           
             557 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            557
uguguugaug gcaugcacua ugcgcggaga auaucc                               36
 
           
             558 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            558
cauugugaug gcaugcacua ugcgcgacug uacucc                               36
 
           
             559 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            559
ucccuugaug gcaugcacua ugcgcgauug cacugu                               36
 
           
             560 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            560
guccuugaug gcaugcacua ugcgcgaugu acuggu                               36
 
           
             561 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            561
auacaugaug gcaugcacua ugcgcgaaag aaagcc                               36
 
           
             562 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            562
aaauaugaug gcaugcacua ugcgcgacaa agaaag                               36
 
           
             563 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            563
uauggugaug gcaugcacua ugcgcgaaau acacaa                               36
 
           
             564 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            564
uuauuugaug gcaugcacua ugcgcgaugg caaaua                               36
 
           
             565 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            565
aguauugaug gcaugcacua ugcgcgauuu auggca                               36
 
           
             566 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            566
uuuagugaug gcaugcacua ugcgcgauua uuuaug                               36
 
           
             567 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            567
aucuuugaug gcaugcacua ugcgcgaaau gauuua                               36
 
           
             568 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            568
gugaaugaug gcaugcacua ugcgcgaucu ucaaau                               36
 
           
             569 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            569
uucucugaug gcaugcacua ugcgcgauaa ugguga                               36
 
           
             570 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            570
aucuuugaug gcaugcacua ugcgcgagag uccuua                               36
 
           
             571 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            571
agguaugaug gcaugcacua ugcgcgaucu ucagag                               36
 
           
             572 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            572
aggacugaug gcaugcacua ugcgcgauag guacau                               36
 
           
             573 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            573
acauuugaug gcaugcacua ugcgcgauuu ccuacu                               36
 
           
             574 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            574
aaucaugaug gcaugcacua ugcgcgauuu auuucc                               36
 
           
             575 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            575
caaauugaug gcaugcacua ugcgcgacau uuauuu                               36
 
           
             576 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            576
gaaggugaug gcaugcacua ugcgcgaaau cacauu                               36
 
           
             577 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            577
aauucugaug gcaugcacua ugcgcgauaa cuucuu                               36
 
           
             578 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            578
uguuuugaug gcaugcacua ugcgcgaaua aaagga                               36
 
           
             579 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            579
aucaaugaug gcaugcacua ugcgcgaccc ugucuu                               36
 
           
             580 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            580
aucauugaug gcaugcacua ugcgcgaaca cccugu                               36
 
           
             581 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            581
ggcauugaug gcaugcacua ugcgcgauca acaccc                               36
 
           
             582 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            582
gaaggugaug gcaugcacua ugcgcgauca ucaaca                               36
 
           
             583 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            583
uaaugugaug gcaugcacua ugcgcgauag aaggca                               36
 
           
             584 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            584
uuucuugaug gcaugcacua ugcgcggaac uaaugu                               36
 
           
             585 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            585
guuuuugaug gcaugcacua ugcgcggaau uucucg                               36
 
           
             586 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            586
uucuuugaug gcaugcacua ugcgcgaugu uuucga                               36
 
           
             587 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            587
uugcuugaug gcaugcacua ugcgcgaucu uuucuu                               36
 
           
             588 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            588
uuuacugaug gcaugcacua ugcgcgaucu uugcuc                               36
 
           
             589 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            589
uuacaugaug gcaugcacua ugcgcgacuu ugucuu                               36
 
           
             590 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            590
aauuaugaug gcaugcacua ugcgcgacac uuuguc                               36
 
           
             591 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            591
auuuaugaug gcaugcacua ugcgcgauaa uuacac                               36
 
           
             592 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            592
aauugugaug gcaugcacua ugcgcgauuu acauaa                               36
 
           
             593 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            593
aaguaugaug gcaugcacua ugcgcgaaau uguauu                               36
 
           
             594 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            594
acuagugaug gcaugcacua ugcgcgaugc cuuaag                               36
 
           
             595 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            595
auguaugaug gcaugcacua ugcgcgaaaa auuacc                               36
 
           
             596 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            596
uaaaaugaug gcaugcacua ugcgcgaaau gcuaau                               36
 
           
             597 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            597
uggagugaug gcaugcacua ugcgcgagga aaaaaa                               36
 
           
             598 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            598
gucugugaug gcaugcacua ugcgcgaugg agcagg                               36
 
           
             599 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            599
gcuaaugaug gcaugcacua ugcgcgaguc ugcaug                               36
 
           
             600 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            600
auaagugaug gcaugcacua ugcgcgauuu aaggua                               36
 
           
             601 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            601
acuguugaug gcaugcacua ugcgcgauuu uaaaau                               36
 
           
             602 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            602
cacuuugaug gcaugcacua ugcgcggagg aaaaaa                               36
 
           
             603 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            603
acuggugaug gcaugcacua ugcgcgacuu cgagga                               36
 
           
             604 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            604
uaguuugaug gcaugcacua ugcgcgaaaa accaaa                               36
 
           
             605 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            605
acaggugaug gcaugcacua ugcgcgauug cuaguu                               36
 
           
             606 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            606
uuucaugaug gcaugcacua ugcgcgaggc auugcu                               36
 
           
             607 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            607
uuuuuugaug gcaugcacua ugcgcgacag gcauug                               36
 
           
             608 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            608
guauuugaug gcaugcacua ugcgcgaguu ucuuuu                               36
 
           
             609 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            609
uuaggugaug gcaugcacua ugcgcgauuc aguuuc                               36
 
           
             610 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            610
caagaugaug gcaugcacua ugcgcgagaa aucuua                               36
 
           
             611 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            611
gcaugugaug gcaugcacua ugcgcgacca aaaacc                               36
 
           
             612 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            612
aacugugaug gcaugcacua ugcgcgaugc accaaa                               36
 
           
             613 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            613
guaauugaug gcaugcacua ugcgcgaacu gcaugc                               36
 
           
             614 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            614
auucaugaug gcaugcacua ugcgcgacuu gguaag                               36
 
           
             615 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            615
acauuugaug gcaugcacua ugcgcgacac uuggua                               36
 
           
             616 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            616
accaaugaug gcaugcacua ugcgcgauuc acacuu                               36
 
           
             617 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            617
uuucaugaug gcaugcacua ugcgcgacca acauuc                               36
 
           
             618 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            618
uguuuugaug gcaugcacua ugcgcgacac caacau                               36
 
           
             619 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            619
agcuuugaug gcaugcacua ugcgcgauua auuugu                               36
 
           
             620 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            620
ugauuugaug gcaugcacua ugcgcgaaaa gcuuca                               36
 
           
             621 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            621
aaacaugaug gcaugcacua ugcgcgagaa uaggga                               36
 
           
             622 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            622
uaaaaugaug gcaugcacua ugcgcgacag aauagg                               36
 
           
             623 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            623
ccauuugaug gcaugcacua ugcgcgaugu gacuag                               36
 
           
             624 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            624
uaaucugaug gcaugcacua ugcgcgauuu auguga                               36
 
           
             625 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            625
ggucuugaug gcaugcacua ugcgcgaacu gaaauu                               36
 
           
             626 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            626
uguuuugaug gcaugcacua ugcgcgagua aaaacc                               36
 
           
             627 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            627
ucccuugaug gcaugcacua ugcgcgaaug uuucag                               36
 
           
             628 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            628
aagccugaug gcaugcacua ugcgcgauaa auuugu                               36
 
           
             629 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            629
aucauugaug gcaugcacua ugcgcgagga agccca                               36
 
           
             630 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            630
aucauugaug gcaugcacua ugcgcgauca ggaagc                               36
 
           
             631 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            631
agaauugaug gcaugcacua ugcgcgauca ucagga                               36
 
           
             632 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            632
uaggaugaug gcaugcacua ugcgcgauga ugccua                               36
 
           
             633 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            633
caaacugaug gcaugcacua ugcgcgauag gacaug                               36
 
           
             634 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            634
gaugaugaug gcaugcacua ugcgcgaaac uauagg                               36
 
           
             635 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            635
uucauugaug gcaugcacua ugcgcgaggg augaca                               36
 
           
             636 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            636
acauuugaug gcaugcacua ugcgcgauca gggaug                               36
 
           
             637 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            637
cuuuaugaug gcaugcacua ugcgcgauuc aucagg                               36
 
           
             638 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            638
gugaaugaug gcaugcacua ugcgcgagug uaacuu                               36
 
           
             639 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            639
ggagaugaug gcaugcacua ugcgcgaaaa ccuuug                               36
 
           
             640 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            640
aauagugaug gcaugcacua ugcgcgagug gaaagg                               36
 
           
             641 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            641
gugacugaug gcaugcacua ugcgcgauga cuaaua                               36
 
           
             642 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            642
uauaaugaug gcaugcacua ugcgcgauuu ugggga                               36
 
           
             643 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            643
aaaaaugaug gcaugcacua ugcgcgauaa uauuuu                               36
 
           
             644 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            644
cuuuuugaug gcaugcacua ugcgcgauag aaaaaa                               36
 
           
             645 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            645
uuuucugaug gcaugcacua ugcgcgauuu uuuucu                               36
 
           
             646 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            646
guuucugaug gcaugcacua ugcgcgauug ccuugu                               36
 
           
             647 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            647
ggccuugaug gcaugcacua ugcgcgauaa uaguuu                               36
 
           
             648 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            648
uaauuugaug gcaugcacua ugcgcgaucu aaugug                               36
 
           
             649 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            649
gucuuugaug gcaugcacua ugcgcgauag uaauuu                               36
 
           
             650 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            650
aaagcugaug gcaugcacua ugcgcgauua ggaguc                               36
 
           
             651 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            651
cuuaaugaug gcaugcacua ugcgcgagga aaaagc                               36
 
           
             652 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            652
ccauuugaug gcaugcacua ugcgcgauac uggguc                               36
 
           
             653 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            653
aauccugaug gcaugcacua ugcgcgauuc auacug                               36
 
           
             654 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            654
guugcugaug gcaugcacua ugcgcgauaa uaaucc                               36
 
           
             655 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            655
guaaaugaug gcaugcacua ugcgcgauag ccccaa                               36
 
           
             656 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            656
aguagugaug gcaugcacua ugcgcgaugu aaauau                               36
 
           
             657 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            657
auuauugaug gcaugcacua ugcgcgauaa aaauuu                               36
 
           
             658 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            658
ucaauugaug gcaugcacua ugcgcgauua uaaaaa                               36
 
           
             659 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            659
cuuuuugaug gcaugcacua ugcgcgaauu auuaua                               36
 
           
             660 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            660
uuuuuugaug gcaugcacua ugcgcgauac uuguua                               36
 
           
             661 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            661
auuccugaug gcaugcacua ugcgcgauga gaauuu                               36
 
           
             662 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            662
gacuaugaug gcaugcacua ugcgcgauuu aauucc                               36
 
           
             663 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            663
ugacaugaug gcaugcacua ugcgcgaggg agacua                               36
 
           
             664 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            664
ucugaugaug gcaugcacua ugcgcgacag ggagac                               36
 
           
             665 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            665
aagagugaug gcaugcacua ugcgcgaguc ugacac                               36
 
           
             666 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            666
uauacugaug gcaugcacua ugcgcgauga aagagc                               36
 
           
             667 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            667
aaaguugaug gcaugcacua ugcgcgauac uaugaa                               36
 
           
             668 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            668
agacuugaug gcaugcacua ugcgcgaagu ugaaga                               36
 
           
             669 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            669
aucuuugaug gcaugcacua ugcgcgaaag acucaa                               36
 
           
             670 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            670
aaaacugaug gcaugcacua ugcgcgaucu ucaaag                               36
 
           
             671 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            671
acaagugaug gcaugcacua ugcgcgagaa uuaaaa                               36
 
           
             672 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            672
ugucaugaug gcaugcacua ugcgcgaagc agaauu                               36
 
           
             673 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            673
aauguugaug gcaugcacua ugcgcgacaa gcagaa                               36
 
           
             674 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            674
uaagcugaug gcaugcacua ugcgcgauaa cuggcc                               36
 
           
             675 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            675
uucaaugaug gcaugcacua ugcgcgaccu aauaag                               36
 
           
             676 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            676
cucuuugaug gcaugcacua ugcgcgaaca ccuaau                               36
 
           
             677 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            677
gcuugugaug gcaugcacua ugcgcgaacc uugguc                               36
 
           
             678 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            678
ucacaugaug gcaugcacua ugcgcgaggg ccuggc                               36
 
           
             679 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            679
guucaugaug gcaugcacua ugcgcgacag ggccug                               36
 
           
             680 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            680
agguuugaug gcaugcacua ugcgcgacac agggcc                               36
 
           
             681 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            681
aagcuugaug gcaugcacua ugcgcgaagg uucaca                               36
 
           
             682 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            682
cucucugaug gcaugcacua ugcgcgauga aagcuc                               36
 
           
             683 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            683
cagucugaug gcaugcacua ugcgcgaugc ugugaa                               36
 
           
             684 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            684
gcacaugaug gcaugcacua ugcgcgaguc caugcu                               36
 
           
             685 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            685
gggcaugaug gcaugcacua ugcgcgacag uccaug                               36
 
           
             686 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            686
uggggugaug gcaugcacua ugcgcgacac agucca                               36
 
           
             687 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            687
ccacuugaug gcaugcacua ugcgcgggau gaccgu                               36
 
           
             688 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            688
ucguaugaug gcaugcacua ugcgcgaacc acucgg                               36
 
           
             689 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            689
ugcauugaug gcaugcacua ugcgcgguac aaccac                               36
 
           
             690 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            690
caaugugaug gcaugcacua ugcgcgaucg uacaac                               36
 
           
             691 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            691
cucccugaug gcaugcacua ugcgcgauuu uugacu                               36
 
           
             692 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            692
ugagcugaug gcaugcacua ugcgcgaucc aaacug                               36
 
           
             693 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            693
gauugugaug gcaugcacua ugcgcgaucu uguuga                               36
 
           
             694 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            694
caccaugaug gcaugcacua ugcgcgagag ugagau                               36
 
           
             695 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            695
gucagugaug gcaugcacua ugcgcgagga ccacca                               36
 
           
             696 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            696
uuuguugaug gcaugcacua ugcgcgagca ggacca                               36
 
           
             697 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            697
aaaagugaug gcaugcacua ugcgcgaaug cucuug                               36
 
           
             698 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            698
agaaaugaug gcaugcacua ugcgcgaaaa gcaaug                               36
 
           
             699 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            699
guuaaugaug gcaugcacua ugcgcgauuu aaaagu                               36
 
           
             700 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            700
aaucuugaug gcaugcacua ugcgcgaacu uuugag                               36
 
           
             701 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            701
uggcaugaug gcaugcacua ugcgcgacca ccaccc                               36
 
           
             702 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            702
cuuggugaug gcaugcacua ugcgcgacac caccac                               36
 
           
             703 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            703
cacuuugaug gcaugcacua ugcgcgauug uuuaaa                               36
 
           
             704 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            704
uuuuuugaug gcaugcacua ugcgcgacuu cauugu                               36
 
           
             705 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            705
uuaugugaug gcaugcacua ugcgcgaaug uuaauu                               36
 
           
             706 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            706
guguuugaug gcaugcacua ugcgcgaugc aauguu                               36
 
           
             707 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            707
uggauugaug gcaugcacua ugcgcgagac uugaaa                               36
 
           
             708 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            708
uuaaaugaug gcaugcacua ugcgcgaugg aucaga                               36
 
           
             709 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            709
agcauugaug gcaugcacua ugcgcgauua aauaug                               36
 
           
             710 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            710
uaaagugaug gcaugcacua ugcgcgauua uuaaau                               36
 
           
             711 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            711
auuuuugaug gcaugcacua ugcgcgauuu uaaagc                               36
 
           
             712 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            712
guuuuugaug gcaugcacua ugcgcgauuu uuauuu                               36
 
           
             713 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            713
uuuauugaug gcaugcacua ugcgcgaaaa ggauug                               36
 
           
             714 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            714
aaauuugaug gcaugcacua ugcgcgauca aaagga                               36
 
           
             715 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            715
aguaaugaug gcaugcacua ugcgcgauuu uaaauu                               36
 
           
             716 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            716
ucauuugaug gcaugcacua ugcgcgauuu uaaaau                               36
 
           
             717 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            717
cacuuugaug gcaugcacua ugcgcgauuu auuuua                               36
 
           
             718 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            718
caucuugaug gcaugcacua ugcgcgacuu cauuua                               36
 
           
             719 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            719
caugcugaug gcaugcacua ugcgcgaucu cacuuc                               36
 
           
             720 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            720
cucacugaug gcaugcacua ugcgcgaugc caucuc                               36
 
           
             721 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            721
caccuugaug gcaugcacua ugcgcgacca ugccau                               36
 
           
             722 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            722
acuuuugaug gcaugcacua ugcgcgaccu caccau                               36
 
           
             723 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            723
accaaugaug gcaugcacua ugcgcgaacc uagucc                               36
 
           
             724 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            724
uaaguugaug gcaugcacua ugcgcgacca acaacc                               36
 
           
             725 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            725
acaccugaug gcaugcacua ugcgcgaucu agaacc                               36
 
           
             726 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            726
aaagaugaug gcaugcacua ugcgcgaccu aucuag                               36
 
           
             727 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            727
aaaauugaug gcaugcacua ugcgcgagag uccuaa                               36
 
           
             728 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            728
guccuugaug gcaugcacua ugcgcgaaaa ucagag                               36
 
           
             729 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            729
uuuaaugaug gcaugcacua ugcgcgauga agaaau                               36
 
           
             730 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            730
aaucaugaug gcaugcacua ugcgcgauag uguaaa                               36
 
           
             731 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            731
uaaauugaug gcaugcacua ugcgcgacau agugua                               36
 
           
             732 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            732
uggaaugaug gcaugcacua ugcgcgauaa aucaca                               36
 
           
             733 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            733
auccuugaug gcaugcacua ugcgcgaugu aaaugg                               36
 
           
             734 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            734
aagugugaug gcaugcacua ugcgcgaucc uuaugu                               36
 
           
             735 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            735
cuugaugaug gcaugcacua ugcgcgaaau aagugu                               36
 
           
             736 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            736
auuuaugaug gcaugcacua ugcgcgagau ugugcu                               36
 
           
             737 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            737
uguaaugaug gcaugcacua ugcgcgauag guuaaa                               36
 
           
             738 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            738
acuggugaug gcaugcacua ugcgcgacug aagaug                               36
 
           
             739 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            739
uugcaugaug gcaugcacua ugcgcgaauu uugccc                               36
 
           
             740 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            740
ucuugugaug gcaugcacua ugcgcgacaa uuuugc                               36
 
           
             741 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            741
aacuuugaug gcaugcacua ugcgcgaccu cuugca                               36
 
           
             742 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            742
ucaaaugaug gcaugcacua ugcgcgauaa acuuca                               36
 
           
             743 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            743
auauuugaug gcaugcacua ugcgcgaaau auaaac                               36
 
           
             744 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            744
auggaugaug gcaugcacua ugcgcgauuc aaauau                               36
 
           
             745 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            745
acuaaugaug gcaugcacua ugcgcgaugg aagaag                               36
 
           
             746 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            746
gaugaugaug gcaugcacua ugcgcgacua auaugg                               36
 
           
             747 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            747
ggaggugaug gcaugcacua ugcgcgaaga ugacac                               36
 
           
             748 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            748
uggggugaug gcaugcacua ugcgcgaugu ggaagg                               36
 
           
             749 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            749
caaguugaug gcaugcacua ugcgcgaugg ggcaug                               36
 
           
             750 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            750
ugcauugaug gcaugcacua ugcgcgaagu cauggg                               36
 
           
             751 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            751
aacugugaug gcaugcacua ugcgcgauca agucau                               36
 
           
             752 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            752
acaagugaug gcaugcacua ugcgcgauua aaacug                               36
 
           
             753 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            753
aauuaugaug gcaugcacua ugcgcgaagu auuaaa                               36
 
           
             754 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            754
aaucuugaug gcaugcacua ugcgcgaugg uuaggg                               36
 
           
             755 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            755
agcagugaug gcaugcacua ugcgcgagua aaucuu                               36
 
           
             756 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            756
cacagugaug gcaugcacua ugcgcgagca guaaau                               36
 
           
             757 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            757
auccaugaug gcaugcacua ugcgcgagca gcagua                               36
 
           
             758 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            758
ggagaugaug gcaugcacua ugcgcgaucc acagca                               36
 
           
             759 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            759
aacuuugaug gcaugcacua ugcgcgaugg agauau                               36
 
           
             760 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            760
ugacuugaug gcaugcacua ugcgcgagug ggaaaa                               36
 
           
             761 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            761
uagggugaug gcaugcacua ugcgcgauuu cugaug                               36
 
           
             762 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            762
ucuguugaug gcaugcacua ugcgcgagau ucucuu                               36
 
           
             763 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            763
uauggugaug gcaugcacua ugcgcgaucu gucaga                               36
 
           
             764 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            764
cccuuugaug gcaugcacua ugcgcgaugg uaucug                               36
 
           
             765 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            765
uagguugaug gcaugcacua ugcgcgaaau cccuuu                               36
 
           
             766 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            766
agcauugaug gcaugcacua ugcgcgagcc accacc                               36
 
           
             767 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            767
caaagugaug gcaugcacua ugcgcgauca gccacc                               36
 
           
             768 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            768
auguuugaug gcaugcacua ugcgcgaaag caucag                               36
 
           
             769 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            769
ggcagugaug gcaugcacua ugcgcgaaag agaugu                               36
 
           
             770 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            770
uugggugaug gcaugcacua ugcgcgagca aagaga                               36
 
           
             771 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            771
acuguugaug gcaugcacua ugcgcggcua auggau                               36
 
           
             772 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            772
cuauuugaug gcaugcacua ugcgcgauac cagggu                               36
 
           
             773 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            773
cugucugaug gcaugcacua ugcgcgauuc auacca                               36
 
           
             774 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            774
aucuuugaug gcaugcacua ugcgcgauua aauucu                               36
 
           
             775 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            775
ugcacugaug gcaugcacua ugcgcgaucu uuauua                               36
 
           
             776 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            776
uucugugaug gcaugcacua ugcgcgacua ucuuua                               36
 
           
             777 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            777
cuaguugaug gcaugcacua ugcgcgauag auuacc                               36
 
           
             778 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            778
gaaugugaug gcaugcacua ugcgcgauua cuguua                               36
 
           
             779 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            779
uaaaaugaug gcaugcacua ugcgcgaaug gaaugu                               36
 
           
             780 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            780
cauugugaug gcaugcacua ugcgcgauga agauuu                               36
 
           
             781 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            781
uuuuuugaug gcaugcacua ugcgcgauug caugaa                               36
 
           
             782 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            782
uaaagugaug gcaugcacua ugcgcgauuu uucauu                               36
 
           
             783 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            783
agcuuugaug gcaugcacua ugcgcgauga auuaaa                               36
 
           
             784 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            784
ucugaugaug gcaugcacua ugcgcgacca aaaaaa                               36
 
           
             785 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            785
aagagugaug gcaugcacua ugcgcggaga cucuga                               36
 
           
             786 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            786
ggugaugaug gcaugcacua ugcgcgaaga gcgaga                               36
 
           
             787 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            787
cacugugaug gcaugcacua ugcgcgauuc cagccu                               36
 
           
             788 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            788
gauggugaug gcaugcacua ugcgcggcca cugcau                               36
 
           
             789 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            789
gguugugaug gcaugcacua ugcgcgagug agcuga                               36
 
           
             790 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            790
agaauugaug gcaugcacua ugcgcggcuu gaaccu                               36
 
           
             791 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            791
cgaggugaug gcaugcacua ugcgcgacga gaaucg                               36
 
           
             792 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            792
cuacuugaug gcaugcacua ugcgcgagga ggccga                               36
 
           
             793 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            793
gugcaugaug gcaugcacua ugcgcgacgc cuguaa                               36
 
           
             794 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            794
uagugugaug gcaugcacua ugcgcgacac gccugu                               36
 
           
             795 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            795
aaauaugaug gcaugcacua ugcgcgaaaa auuagu                               36
 
           
             796 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            796
gccaaugaug gcaugcacua ugcgcgaggu gaaacc                               36
 
           
             797 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            797
gaguuugaug gcaugcacua ugcgcggaga ccagcc                               36
 
           
             798 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            798
gagguugaug gcaugcacua ugcgcgagga guucga                               36
 
           
             799 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            799
ugaauugaug gcaugcacua ugcgcgacuu gagguc                               36
 
           
             800 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            800
agguuugaug gcaugcacua ugcgcgauga ggccaa                               36
 
           
             801 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            801
caaaaugaug gcaugcacua ugcgcgaggu uuauga                               36
 
           
             802 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            802
uucugugaug gcaugcacua ugcgcgaaaa cagguu                               36
 
           
             803 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            803
auaaaugaug gcaugcacua ugcgcgauuu gcugaa                               36
 
           
             804 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            804
gcacuugaug gcaugcacua ugcgcgaaua aauauu                               36
 
           
             805 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            805
guaggugaug gcaugcacua ugcgcgacuc aauaaa                               36
 
           
             806 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            806
acuggugaug gcaugcacua ugcgcgaucu gguagg                               36
 
           
             807 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            807
uugugugaug gcaugcacua ugcgcgggug acuggc                               36
 
           
             808 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            808
uaccaugaug gcaugcacua ugcgcgauac ccagug                               36
 
           
             809 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            809
gauacugaug gcaugcacua ugcgcgauau acccag                               36
 
           
             810 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            810
gggauugaug gcaugcacua ugcgcgaugu cucuug                               36
 
           
             811 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            811
acuagugaug gcaugcacua ugcgcgagua ccuaag                               36
 
           
             812 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            812
gaccaugaug gcaugcacua ugcgcgacua gcagua                               36
 
           
             813 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            813
uauuaugaug gcaugcacua ugcgcgagac cacacu                               36
 
           
             814 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            814
uaagaugaug gcaugcacua ugcgcgauua cagacc                               36
 
           
             815 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            815
ggucgugaug gcaugcacua ugcgcgauac caaagg                               36
 
           
             816 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            816
uggguugaug gcaugcacua ugcgcgguau accaaa                               36
 
           
             817 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            817
cguguugaug gcaugcacua ugcgcgaucu cugggu                               36
 
           
             818 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            818
cgcauugaug gcaugcacua ugcgcggugu uaucuc                               36
 
           
             819 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            819
auacgugaug gcaugcacua ugcgcgaucg uguuau                               36
 
           
             820 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            820
cuuugugaug gcaugcacua ugcgcgaaaa cuaaaa                               36
 
           
             821 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            821
uggcaugaug gcaugcacua ugcgcgagag accaaa                               36
 
           
             822 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            822
gcuggugaug gcaugcacua ugcgcgacag agacca                               36
 
           
             823 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            823
acaauugaug gcaugcacua ugcgcgauag agcugg                               36
 
           
             824 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            824
caaaaugaug gcaugcacua ugcgcgaauu auagag                               36
 
           
             825 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            825
cguagugaug gcaugcacua ugcgcgaaaa caauua                               36
 
           
             826 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            826
ggaauugaug gcaugcacua ugcgcgguag caaaac                               36
 
           
             827 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            827
aguuuugaug gcaugcacua ugcgcgagug gaaucg                               36
 
           
             828 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            828
uugauugaug gcaugcacua ugcgcggaag aguuuc                               36
 
           
             829 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            829
auuuaugaug gcaugcacua ugcgcgauaa aguagc                               36
 
           
             830 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            830
uaaaaugaug gcaugcacua ugcgcgaaug aaguga                               36
 
           
             831 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            831
aaguuugaug gcaugcacua ugcgcgauuc cuuuaa                               36
 
           
             832 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            832
auaauugaug gcaugcacua ugcgcgaagu uuauuc                               36
 
           
             833 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            833
aacaaugaug gcaugcacua ugcgcgauaa ucaagu                               36
 
           
             834 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            834
aaaaaugaug gcaugcacua ugcgcgaaua uaauca                               36
 
           
             835 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            835
acaguugaug gcaugcacua ugcgcgaugc caaaua                               36
 
           
             836 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            836
aaucaugaug gcaugcacua ugcgcgaguu augcca                               36
 
           
             837 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            837
agaauugaug gcaugcacua ugcgcgacag uuaugc                               36
 
           
             838 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            838
guguaugaug gcaugcacua ugcgcgagua auuguc                               36
 
           
             839 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            839
acauaugaug gcaugcacua ugcgcgaccu uaaugu                               36
 
           
             840 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            840
ucugaugaug gcaugcacua ugcgcgauac accuua                               36
 
           
             841 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            841
augaaugaug gcaugcacua ugcgcgaucu gacaua                               36
 
           
             842 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            842
gucaaugaug gcaugcacua ugcgcgauga auaucu                               36
 
           
             843 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            843
uggguugaug gcaugcacua ugcgcgaaua ugaaua                               36
 
           
             844 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            844
uuacaugaug gcaugcacua ugcgcgauuu ggguca                               36
 
           
             845 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            845
uauuaugaug gcaugcacua ugcgcgacau uugggu                               36
 
           
             846 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            846
uggaaugaug gcaugcacua ugcgcgauua cacauu                               36
 
           
             847 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            847
uuaugugaug gcaugcacua ugcgcgagag aaaacu                               36
 
           
             848 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            848
uuacuugaug gcaugcacua ugcgcgaugc agagaa                               36
 
           
             849 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            849
aaguaugaug gcaugcacua ugcgcgauuu uaauua                               36
 
           
             850 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            850
uuaagugaug gcaugcacua ugcgcgauau uuuaau                               36
 
           
             851 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            851
aaaacugaug gcaugcacua ugcgcgauua auuuuu                               36
 
           
             852 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            852
cuguuugaug gcaugcacua ugcgcgauuu guaccc                               36
 
           
             853 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            853
ucaggugaug gcaugcacua ugcgcgacug uuuauu                               36
 
           
             854 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            854
uaguuugaug gcaugcacua ugcgcgaggc acuguu                               36
 
           
             855 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            855
uuuuaugaug gcaugcacua ugcgcgauag aaguuu                               36
 
           
             856 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            856
gaaauugaug gcaugcacua ugcgcgauag ugauuu                               36
 
           
             857 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            857
caauuugaug gcaugcacua ugcgcgagaa aucaua                               36
 
           
             858 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            858
cauagugaug gcaugcacua ugcgcgaauu cagaaa                               36
 
           
             859 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            859
uuucaugaug gcaugcacua ugcgcgauag caauuc                               36
 
           
             860 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            860
aguuuugaug gcaugcacua ugcgcgacau agcaau                               36
 
           
             861 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            861
cuaaaugaug gcaugcacua ugcgcgagug uuccaa                               36
 
           
             862 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            862
cuuaaugaug gcaugcacua ugcgcgaccc uaccua                               36
 
           
             863 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            863
uguguugaug gcaugcacua ugcgcgaagu cuuaac                               36
 
           
             864 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            864
auggcugaug gcaugcacua ugcgcgauuu cuuucu                               36
 
           
             865 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            865
ugaagugaug gcaugcacua ugcgcgaugg ccauuu                               36
 
           
             866 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            866
cacugugaug gcaugcacua ugcgcgaguu ccugaa                               36
 
           
             867 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            867
auaagugaug gcaugcacua ugcgcgacug caguuc                               36
 
           
             868 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            868
ccccuugaug gcaugcacua ugcgcgauaa gcacug                               36
 
           
             869 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            869
cuaaaugaug gcaugcacua ugcgcgaucc ccucau                               36
 
           
             870 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            870
aaauuugaug gcaugcacua ugcgcgaaga ggccua                               36
 
           
             871 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            871
uacauugaug gcaugcacua ugcgcgaaaa auucaa                               36
 
           
             872 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            872
aucuaugaug gcaugcacua ugcgcgauca aaaauu                               36
 
           
             873 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            873
augccugaug gcaugcacua ugcgcgaucu acauca                               36
 
           
             874 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            874
guucaugaug gcaugcacua ugcgcgauaa agguaa                               36
 
           
             875 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            875
aaguuugaug gcaugcacua ugcgcgacau aaaggu                               36
 
           
             876 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            876
ccauuugaug gcaugcacua ugcgcgaaag uucaca                               36
 
           
             877 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            877
uaaacugaug gcaugcacua ugcgcgauuc aaaguu                               36
 
           
             878 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            878
aaaaaugaug gcaugcacua ugcgcgaaau cuuuug                               36
 
           
             879 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            879
cucuaugaug gcaugcacua ugcgcgaaaa acaaau                               36
 
           
             880 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            880
acauuugaug gcaugcacua ugcgcgauuu cuagaa                               36
 
           
             881 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            881
gguaaugaug gcaugcacua ugcgcgauuu auuucu                               36
 
           
             882 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            882
uucaaugaug gcaugcacua ugcgcgaagg auuuuu                               36
 
           
             883 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            883
aacuuugaug gcaugcacua ugcgcgaaca aggauu                               36
 
           
             884 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            884
aagucugaug gcaugcacua ugcgcgaugu aauuua                               36
 
           
             885 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            885
acaaaugaug gcaugcacua ugcgcgaugu uaaugc                               36
 
           
             886 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            886
uuccaugaug gcaugcacua ugcgcgaaac auguua                               36
 
           
             887 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            887
ugcuaugaug gcaugcacua ugcgcgauuc uuccac                               36
 
           
             888 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            888
ucugcugaug gcaugcacua ugcgcgauau ucuucc                               36
 
           
             889 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            889
uacaaugaug gcaugcacua ugcgcgauac gucugc                               36
 
           
             890 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            890
ugauaugaug gcaugcacua ugcgcgaaua uacguc                               36
 
           
             891 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            891
ucacuugaug gcaugcacua ugcgcgaaau gauaca                               36
 
           
             892 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            892
acauuugaug gcaugcacua ugcgcgacuc aaauga                               36
 
           
             893 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            893
gggaaugaug gcaugcacua ugcgcgauuc acucaa                               36
 
           
             894 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            894
ugacuugaug gcaugcacua ugcgcgaguu aaauag                               36
 
           
             895 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            895
cuaugugaug gcaugcacua ugcgcgagug ugacuc                               36
 
           
             896 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            896
auuccugaug gcaugcacua ugcgcgaugc agugug                               36
 
           
             897 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            897
uaaccugaug gcaugcacua ugcgcgauaa aaguua                               36
 
           
             898 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            898
gacaaugaug gcaugcacua ugcgcgaguu uugaua                               36
 
           
             899 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            899
ggugaugaug gcaugcacua ugcgcgaaca guuuug                               36
 
           
             900 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            900
uugugugaug gcaugcacua ugcgcgaaug gugaca                               36
 
           
             901 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            901
uaggaugaug gcaugcacua ugcgcgaaaa uugugc                               36
 
           
             902 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            902
guauaugaug gcaugcacua ugcgcgauua ggacaa                               36
 
           
             903 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            903
auguaugaug gcaugcacua ugcgcgauau uaggac                               36
 
           
             904 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            904
cuaugugaug gcaugcacua ugcgcgauau auuagg                               36
 
           
             905 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            905
guuucugaug gcaugcacua ugcgcgaugu auauau                               36
 
           
             906 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            906
ccccaugaug gcaugcacua ugcgcgaaag uuucua                               36
 
           
             907 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            907
cuuaaugaug gcaugcacua ugcgcgaugc cccaca                               36
 
           
             908 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            908
uugugugaug gcaugcacua ugcgcgaaac uguaac                               36
 
           
             909 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            909
gaauaugaug gcaugcacua ugcgcgaaau gagaug                               36
 
           
             910 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            910
aaaauugaug gcaugcacua ugcgcgaaug gaauac                               36
 
           
             911 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            911
uuauaugaug gcaugcacua ugcgcgauac uguuuu                               36
 
           
             912 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            912
aguuaugaug gcaugcacua ugcgcgauau acuguu                               36
 
           
             913 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            913
aaaguugaug gcaugcacua ugcgcgauau auacug                               36
 
           
             914 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            914
aucuuugaug gcaugcacua ugcgcgagau aguuuu                               36
 
           
             915 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            915
uuugaugaug gcaugcacua ugcgcgaaau ggaaau                               36
 
           
             916 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            916
gaaauugaug gcaugcacua ugcgcgauua cuuuuu                               36
 
           
             917 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            917
auuauugaug gcaugcacua ugcgcgaaga aaucau                               36
 
           
             918 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            918
acaauugaug gcaugcacua ugcgcgauca agaaau                               36
 
           
             919 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            919
cuacaugaug gcaugcacua ugcgcgaauu aucaag                               36
 
           
             920 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            920
cacuaugaug gcaugcacua ugcgcgacaa uuauca                               36
 
           
             921 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            921
acauuugaug gcaugcacua ugcgcgacua cacaau                               36
 
           
             922 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            922
aaaaaugaug gcaugcacua ugcgcgauuc acuaca                               36
 
           
             923 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            923
gcuuuugaug gcaugcacua ugcgcgaagg uaacug                               36
 
           
             924 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            924
aaauuugaug gcaugcacua ugcgcgagcu uucaag                               36
 
           
             925 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            925
cuaaaugaug gcaugcacua ugcgcgauaa auucag                               36
 
           
             926 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            926
uaacaugaug gcaugcacua ugcgcgagaa guuacu                               36
 
           
             927 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            927
auuaaugaug gcaugcacua ugcgcgacag aaguua                               36
 
           
             928 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            928
uccagugaug gcaugcacua ugcgcgauua acacag                               36
 
           
             929 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            929
caugcugaug gcaugcacua ugcgcgaucc aguauu                               36
 
           
             930 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            930
gaauuugaug gcaugcacua ugcgcgaugc uaucca                               36
 
           
             931 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            931
caaugugaug gcaugcacua ugcgcgagaa uucaug                               36
 
           
             932 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            932
uuucuugaug gcaugcacua ugcgcgaaug cagaau                               36
 
           
             933 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            933
cuauuugaug gcaugcacua ugcgcgaguu ucucaa                               36
 
           
             934 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            934
acagcugaug gcaugcacua ugcgcgauuc aguuuc                               36
 
           
             935 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            935
uaugaugaug gcaugcacua ugcgcgagcu auucag                               36
 
           
             936 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            936
cauuuugaug gcaugcacua ugcgcgauga cagcua                               36
 
           
             937 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            937
gaaagugaug gcaugcacua ugcgcgauuu uaugac                               36
 
           
             938 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            938
gugagugaug gcaugcacua ugcgcgaucu uucuuu                               36
 
           
             939 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            939
gaacuugaug gcaugcacua ugcgcgaugu gaguau                               36
 
           
             940 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            940
uucuuugaug gcaugcacua ugcgcgaaga acucau                               36
 
           
             941 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            941
augacugaug gcaugcacua ugcgcgauuc uucaag                               36
 
           
             942 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            942
cuaguugaug gcaugcacua ugcgcgauga cuauuc                               36
 
           
             943 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            943
aaacaugaug gcaugcacua ugcgcgagau cuuaau                               36
 
           
             944 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            944
uaaaaugaug gcaugcacua ugcgcgacag aucuua                               36
 
           
             945 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            945
caaacugaug gcaugcacua ugcgcgauua aacuaa                               36
 
           
             946 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            946
cacuuugaug gcaugcacua ugcgcgaaac uauuaa                               36
 
           
             947 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            947
acaggugaug gcaugcacua ugcgcgacuu caaacu                               36
 
           
             948 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            948
ccaaaugaug gcaugcacua ugcgcgaggc acuuca                               36
 
           
             949 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            949
aucauugaug gcaugcacua ugcgcgaucc caaaca                               36
 
           
             950 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            950
ccuauugaug gcaugcacua ugcgcgauua ucccaa                               36
 
           
             951 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            951
uuaccugaug gcaugcacua ugcgcgauca uuaucc                               36
 
           
             952 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            952
aaauuugaug gcaugcacua ugcgcgaucu aaauua                               36
 
           
             953 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            953
aacugugaug gcaugcacua ugcgcgagau aacuuu                               36
 
           
             954 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            954
cucaaugaug gcaugcacua ugcgcgauaa cugcag                               36
 
           
             955 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            955
gcccuugaug gcaugcacua ugcgcgaaca uaacug                               36
 
           
             956 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            956
uaaaaugaug gcaugcacua ugcgcgacug uaaccc                               36
 
           
             957 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            957
acuuuugaug gcaugcacua ugcgcgggau aaaaca                               36
 
           
             958 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            958
caagaugaug gcaugcacua ugcgcgagug gaauug                               36
 
           
             959 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            959
aaacaugaug gcaugcacua ugcgcgaaga cagugg                               36
 
           
             960 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            960
gaaaaugaug gcaugcacua ugcgcgacaa gacagu                               36
 
           
             961 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            961
uucaaugaug gcaugcacua ugcgcgauga aaacac                               36
 
           
             962 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            962
auuuuugaug gcaugcacua ugcgcgaaca ugaaaa                               36
 
           
             963 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            963
aaaagugaug gcaugcacua ugcgcgauuu ucaaca                               36
 
           
             964 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            964
aaaugugaug gcaugcacua ugcgcgaaaa guauuu                               36
 
           
             965 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            965
gcacuugaug gcaugcacua ugcgcgaaag gaaaaa                               36
 
           
             966 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            966
auuggugaug gcaugcacua ugcgcgacuc aaagga                               36
 
           
             967 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            967
uguuaugaug gcaugcacua ugcgcgauua agaaau                               36
 
           
             968 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            968
guaaaugaug gcaugcacua ugcgcgaugu uacauu                               36
 
           
             969 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            969
aaagaugaug gcaugcacua ugcgcgaggc caggua                               36
 
           
             970 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            970
cuauaugaug gcaugcacua ugcgcgaaaa auaguu                               36
 
           
             971 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            971
uacacugaug gcaugcacua ugcgcgauac aaaaau                               36
 
           
             972 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            972
guuuaugaug gcaugcacua ugcgcgacua uacaaa                               36
 
           
             973 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            973
uguuuugaug gcaugcacua ugcgcgaguu uacacu                               36
 
           
             974 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            974
augugugaug gcaugcacua ugcgcgaugu uucagu                               36
 
           
             975 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            975
auguaugaug gcaugcacua ugcgcgaaaa ugugca                               36
 
           
             976 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            976
aagcaugaug gcaugcacua ugcgcgaaug uacaaa                               36
 
           
             977 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            977
gaaagugaug gcaugcacua ugcgcgacaa uguaca                               36
 
           
             978 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            978
acccaugaug gcaugcacua ugcgcgaaaa gaaagc                               36
 
           
             979 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            979
cugcaugaug gcaugcacua ugcgcgauga cccaca                               36
 
           
             980 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            980
cacugugaug gcaugcacua ugcgcgauau gaccca                               36
 
           
             981 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            981
gaucaugaug gcaugcacua ugcgcgacug cauaug                               36
 
           
             982 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            982
uggauugaug gcaugcacua ugcgcgacac ugcaua                               36
 
           
             983 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            983
gaaaaugaug gcaugcacua ugcgcgaacu ggauca                               36
 
           
             984 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            984
cagcgugaug gcaugcacua ugcgcgaacc aaauga                               36
 
           
             985 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            985
gucagugaug gcaugcacua ugcgcggcaa ccaaau                               36
 
           
             986 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            986
uagguugaug gcaugcacua ugcgcgagcg caacca                               36
 
           
             987 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            987
accaaugaug gcaugcacua ugcgcgauuc cuaggu                               36
 
           
             988 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            988
uuugaugaug gcaugcacua ugcgcgauga ccaaca                               36
 
           
             989 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            989
gugguugaug gcaugcacua ugcgcgauuu uuaaug                               36
 
           
             990 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            990
aauuuugaug gcaugcacua ugcgcgauua aaagag                               36
 
           
             991 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            991
auaaaugaug gcaugcacua ugcgcgauuu aaaagu                               36
 
           
             992 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            992
acuccugaug gcaugcacua ugcgcgauaa acauuu                               36
 
           
             993 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            993
cagcaugaug gcaugcacua ugcgcgauac uccuau                               36
 
           
             994 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            994
cacagugaug gcaugcacua ugcgcgacau acuccu                               36
 
           
             995 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            995
cuucaugaug gcaugcacua ugcgcgagca cauacu                               36
 
           
             996 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            996
cacuuugaug gcaugcacua ugcgcgacag cacaua                               36
 
           
             997 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            997
uagauugaug gcaugcacua ugcgcgacuu cacagc                               36
 
           
             998 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            998
uauuaugaug gcaugcacua ugcgcgaaau uuuaga                               36
 
           
             999 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            999
aaaaaugaug gcaugcacua ugcgcgauua caaauu                               36
 
           
             1000 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1000
caugaugaug gcaugcacua ugcgcgaaaa auauua                               36
 
           
             1001 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1001
caguuugaug gcaugcacua ugcgcgauga caaaaa                               36
 
           
             1002 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1002
uaguaugaug gcaugcacua ugcgcgaguu caugac                               36
 
           
             1003 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1003
cauuaugaug gcaugcacua ugcgcgaaua auuagg                               36
 
           
             1004 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1004
uauuaugaug gcaugcacua ugcgcgauua caauaa                               36
 
           
             1005 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1005
auuuuugaug gcaugcacua ugcgcgauua cauuac                               36
 
           
             1006 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1006
guaacugaug gcaugcacua ugcgcgauuu uuauua                               36
 
           
             1007 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1007
auaguugaug gcaugcacua ugcgcgacug uaacua                               36
 
           
             1008 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1008
acacuugaug gcaugcacua ugcgcgauag ucacug                               36
 
           
             1009 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1009
auacaugaug gcaugcacua ugcgcgacuc auaguc                               36
 
           
             1010 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1010
aaauaugaug gcaugcacua ugcgcgacac ucauag                               36
 
           
             1011 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1011
auuugugaug gcaugcacua ugcgcgauga auaaau                               36
 
           
             1012 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1012
caguuugaug gcaugcacua ugcgcgaaau uugcau                               36
 
           
             1013 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1013
gcaaaugaug gcaugcacua ugcgcgaguu caaauu                               36
 
           
             1014 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1014
cggggugaug gcaugcacua ugcgcgaaac aguuca                               36
 
           
             1015 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1015
cauuuugaug gcaugcacua ugcgcggggg caaaca                               36
 
           
             1016 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1016
auaucugaug gcaugcacua ugcgcgauuu cggggc                               36
 
           
             1017 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1017
auccaugaug gcaugcacua ugcgcgaucc auuucg                               36
 
           
             1018 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1018
guaucugaug gcaugcacua ugcgcgauau ccauuu                               36
 
           
             1019 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1019
uaaagugaug gcaugcacua ugcgcgaucc auaucc                               36
 
           
             1020 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1020
uggcuugaug gcaugcacua ugcgcgauaa aguauc                               36
 
           
             1021 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1021
gugucugaug gcaugcacua ugcgcgaugg cuuaua                               36
 
           
             1022 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1022
uauacugaug gcaugcacua ugcgcgauag ugucua                               36
 
           
             1023 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1023
acuggugaug gcaugcacua ugcgcgauac uauagu                               36
 
           
             1024 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1024
agauuugaug gcaugcacua ugcgcgacug guauac                               36
 
           
             1025 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1025
agcugugaug gcaugcacua ugcgcgauaa aagauu                               36
 
           
             1026 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1026
ucuaaugaug gcaugcacua ugcgcgaagc ugcaua                               36
 
           
             1027 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1027
cacagugaug gcaugcacua ugcgcgaccu uuuaga                               36
 
           
             1028 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1028
auccaugaug gcaugcacua ugcgcgagca ccuuuu                               36
 
           
             1029 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1029
cauaaugaug gcaugcacua ugcgcgaucc acagca                               36
 
           
             1030 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1030
cuuuaugaug gcaugcacua ugcgcgauaa uaucca                               36
 
           
             1031 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1031
gcaaaugaug gcaugcacua ugcgcgacgc cuuuac                               36
 
           
             1032 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1032
uuaagugaug gcaugcacua ugcgcgaaac acgccu                               36
 
           
             1033 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1033
cuaaaugaug gcaugcacua ugcgcgaugg aaaauu                               36
 
           
             1034 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1034
uuuugugaug gcaugcacua ugcgcgaucu acuucu                               36
 
           
             1035 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1035
aaaggugaug gcaugcacua ugcgcgagau uuguuu                               36
 
           
             1036 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1036
uuuguugaug gcaugcacua ugcgcgauaa aggcag                               36
 
           
             1037 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1037
uauccugaug gcaugcacua ugcgcgauuu uuuugu                               36
 
           
             1038 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1038
aauguugaug gcaugcacua ugcgcgaucc uauuuu                               36
 
           
             1039 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1039
uaccuugaug gcaugcacua ugcgcgauug auaaaa                               36
 
           
             1040 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1040
uguauugaug gcaugcacua ugcgcgaauu accuua                               36
 
           
             1041 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1041
uugugugaug gcaugcacua ugcgcgauca auuacc                               36
 
           
             1042 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1042
caaguugaug gcaugcacua ugcgcgaccu guugug                               36
 
           
             1043 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1043
uccauugaug gcaugcacua ugcgcgauua auguug                               36
 
           
             1044 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1044
auuucugaug gcaugcacua ugcgcgauua uuaaug                               36
 
           
             1045 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1045
ucaauugaug gcaugcacua ugcgcgauuu ccauua                               36
 
           
             1046 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1046
cuauuugaug gcaugcacua ugcgcgaauu auuucc                               36
 
           
             1047 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1047
cuaacugaug gcaugcacua ugcgcgauuc aauuau                               36
 
           
             1048 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1048
acauaugaug gcaugcacua ugcgcgauaa cuaacu                               36
 
           
             1049 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1049
auuaaugaug gcaugcacua ugcgcgauac auaacu                               36
 
           
             1050 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1050
acuggugaug gcaugcacua ugcgcgauua acauac                               36
 
           
             1051 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1051
ggaguugaug gcaugcacua ugcgcgauua cuucug                               36
 
           
             1052 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1052
auaugugaug gcaugcacua ugcgcgaugg agucau                               36
 
           
             1053 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1053
aauaaugaug gcaugcacua ugcgcgaugu auggag                               36
 
           
             1054 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1054
guaguugaug gcaugcacua ugcgcgauag aaauaa                               36
 
           
             1055 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1055
aacguugaug gcaugcacua ugcgcgaugg cuaggc                               36
 
           
             1056 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1056
aacggugaug gcaugcacua ugcgcgaugg cuaggc                               36
 
           
             1057 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1057
aacguugaug gcaugcacua ugcgcggugg cuaggc                               36
 
           
             1058 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1058
aacguugaug gcaugcacua ugcgcguugg cuaggc                               36
 
           
             1059 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1059
aacgaugaug gcaugcacua ugcgcgaugg cuaggc                               36
 
           
             1060 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1060
aacgaugaug gcaugcacua ugcgcggugg cuaggc                               36
 
           
             1061 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1061
aacggugaug gcaugcacua ugcgcggugg cuaggc                               36
 
           
             1062 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1062
aacggugaug gcaugcacua ugcgcguugg cuaggc                               36
 
           
             1063 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1063
aacgaugaug gcaugcacua ugcgcguugg cuaggc                               36
 
           
             1064 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1064
aacgcugaug gcaugcacua ugcgcggugg cuaggc                               36
 
           
             1065 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1065
aacgcugaug gcaugcacua ugcgcgaugg cuaggc                               36
 
           
             1066 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1066
aacguugaug gcaugcacua ugcgcgcugg cuaggc                               36
 
           
             1067 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1067
aacggugaug gcaugcacua ugcgcgcugg cuaggc                               36
 
           
             1068 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1068
aacgcugaug gcaugcacua ugcgcguugg cuaggc                               36
 
           
             1069 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1069
aacgaugaug gcaugcacua ugcgcgcugg cuaggc                               36
 
           
             1070 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1070
aacgcugaug gcaugcacua ugcgcgcugg cuaggc                               36
 
           
             1071 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1071
agcugugaug gcaugcacua ugcgcgaucg ucaaggn                              37
 
           
             1072 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1072
gaucaugaug gcaugcacua ugcgcgauuc guccacn                              37
 
           
             1073 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1073
uucucugaug gcaugcacua ugcgcgauca auuacun                              37
 
           
             1074 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1074
gagaaugaug gcaugcacua ugcgcgaucc aagagan                              37
 
           
             1075 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1075
ucccuugaug gcaugcacua ugcgcgauug cacugun                              37
 
           
             1076 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1076
guccuugaug gcaugcacua ugcgcgaugu acuggun                              37
 
           
             1077 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1077
aguauugaug gcaugcacua ugcgcgauuu auggcan                              37
 
           
             1078 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1078
agguaugaug gcaugcacua ugcgcgaucu ucagagn                              37
 
           
             1079 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1079
aggacugaug gcaugcacua ugcgcgauag guacaun                              37
 
           
             1080 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1080
aaucaugaug gcaugcacua ugcgcgauuu auuuccn                              37
 
           
             1081 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1081
aauucugaug gcaugcacua ugcgcgauaa cuucuun                              37
 
           
             1082 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1082
ggcauugaug gcaugcacua ugcgcgauca acacccn                              37
 
           
             1083 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1083
gaaggugaug gcaugcacua ugcgcgauca ucaacan                              37
 
           
             1084 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1084
uaaugugaug gcaugcacua ugcgcgauag aaggcan                              37
 
           
             1085 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1085
uuuacugaug gcaugcacua ugcgcgaucu uugcucn                              37
 
           
             1086 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1086
auaagugaug gcaugcacua ugcgcgauuu aagguan                              37
 
           
             1087 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1087
acaggugaug gcaugcacua ugcgcgauug cuaguun                              37
 
           
             1088 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1088
aacugugaug gcaugcacua ugcgcgaugc accaaan                              37
 
           
             1089 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1089
accaaugaug gcaugcacua ugcgcgauuc acacuun                              37
 
           
             1090 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1090
agcuuugaug gcaugcacua ugcgcgauua auuugun                              37
 
           
             1091 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1091
uaaucugaug gcaugcacua ugcgcgauuu augugan                              37
 
           
             1092 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1092
aagccugaug gcaugcacua ugcgcgauaa auuugun                              37
 
           
             1093 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1093
aucauugaug gcaugcacua ugcgcgauca ggaagcn                              37
 
           
             1094 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1094
agaauugaug gcaugcacua ugcgcgauca ucaggan                              37
 
           
             1095 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1095
acauuugaug gcaugcacua ugcgcgauca gggaugn                              37
 
           
             1096 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1096
cuuuaugaug gcaugcacua ugcgcgauuc aucaggn                              37
 
           
             1097 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1097
guuucugaug gcaugcacua ugcgcgauug ccuugun                              37
 
           
             1098 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1098
ggccuugaug gcaugcacua ugcgcgauaa uaguuun                              37
 
           
             1099 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1099
aaagcugaug gcaugcacua ugcgcgauua ggagucn                              37
 
           
             1100 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1100
aauccugaug gcaugcacua ugcgcgauuc auacugn                              37
 
           
             1101 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1101
guugcugaug gcaugcacua ugcgcgauaa uaauccn                              37
 
           
             1102 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1102
uaagcugaug gcaugcacua ugcgcgauaa cuggccn                              37
 
           
             1103 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1103
cucucugaug gcaugcacua ugcgcgauga aagcucn                              37
 
           
             1104 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1104
cagucugaug gcaugcacua ugcgcgaugc ugugaan                              37
 
           
             1105 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1105
caaugugaug gcaugcacua ugcgcgaucg uacaacn                              37
 
           
             1106 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1106
ugagcugaug gcaugcacua ugcgcgaucc aaacugn                              37
 
           
             1107 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1107
cacuuugaug gcaugcacua ugcgcgauug uuuaaan                              37
 
           
             1108 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1108
guguuugaug gcaugcacua ugcgcgaugc aauguun                              37
 
           
             1109 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1109
uuaaaugaug gcaugcacua ugcgcgaugg aucagan                              37
 
           
             1110 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1110
caugcugaug gcaugcacua ugcgcgaucu cacuucn                              37
 
           
             1111 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1111
cucacugaug gcaugcacua ugcgcgaugc caucucn                              37
 
           
             1112 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1112
acaccugaug gcaugcacua ugcgcgaucu agaaccn                              37
 
           
             1113 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1113
uuuaaugaug gcaugcacua ugcgcgauga agaaaun                              37
 
           
             1114 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1114
uggaaugaug gcaugcacua ugcgcgauaa aucacan                              37
 
           
             1115 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1115
auccuugaug gcaugcacua ugcgcgaugu aaauggn                              37
 
           
             1116 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1116
aacugugaug gcaugcacua ugcgcgauca agucaun                              37
 
           
             1117 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1117
aaucuugaug gcaugcacua ugcgcgaugg uuagggn                              37
 
           
             1118 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1118
ggagaugaug gcaugcacua ugcgcgaucc acagcan                              37
 
           
             1119 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1119
aacuuugaug gcaugcacua ugcgcgaugg agauaun                              37
 
           
             1120 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1120
uagggugaug gcaugcacua ugcgcgauuu cugaugn                              37
 
           
             1121 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1121
cccuuugaug gcaugcacua ugcgcgaugg uaucugn                              37
 
           
             1122 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1122
caaagugaug gcaugcacua ugcgcgauca gccaccn                              37
 
           
             1123 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1123
cuauuugaug gcaugcacua ugcgcgauac cagggun                              37
 
           
             1124 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1124
cauugugaug gcaugcacua ugcgcgauga agauuun                              37
 
           
             1125 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1125
agcuuugaug gcaugcacua ugcgcgauga auuaaan                              37
 
           
             1126 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1126
cacugugaug gcaugcacua ugcgcgauuc cagccun                              37
 
           
             1127 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1127
agguuugaug gcaugcacua ugcgcgauga ggccaan                              37
 
           
             1128 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1128
auaaaugaug gcaugcacua ugcgcgauuu gcugaan                              37
 
           
             1129 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1129
acuggugaug gcaugcacua ugcgcgaucu gguaggn                              37
 
           
             1130 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1130
uaccaugaug gcaugcacua ugcgcgauac ccagugn                              37
 
           
             1131 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1131
gauacugaug gcaugcacua ugcgcgauau acccagn                              37
 
           
             1132 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1132
gggauugaug gcaugcacua ugcgcgaugu cucuugn                              37
 
           
             1133 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1133
ggucgugaug gcaugcacua ugcgcgauac caaaggn                              37
 
           
             1134 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1134
cguguugaug gcaugcacua ugcgcgaucu cugggun                              37
 
           
             1135 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1135
auacgugaug gcaugcacua ugcgcgaucg uguuaun                              37
 
           
             1136 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1136
acaauugaug gcaugcacua ugcgcgauag agcuggn                              37
 
           
             1137 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1137
aaguuugaug gcaugcacua ugcgcgauuc cuuuaan                              37
 
           
             1138 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1138
acaguugaug gcaugcacua ugcgcgaugc caaauan                              37
 
           
             1139 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1139
uuacaugaug gcaugcacua ugcgcgauuu gggucan                              37
 
           
             1140 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1140
uggaaugaug gcaugcacua ugcgcgauua cacauun                              37
 
           
             1141 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1141
uuacuugaug gcaugcacua ugcgcgaugc agagaan                              37
 
           
             1142 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1142
cuguuugaug gcaugcacua ugcgcgauuu guacccn                              37
 
           
             1143 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1143
uuucaugaug gcaugcacua ugcgcgauag caauucn                              37
 
           
             1144 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1144
auggcugaug gcaugcacua ugcgcgauuu cuuucun                              37
 
           
             1145 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1145
ugaagugaug gcaugcacua ugcgcgaugg ccauuun                              37
 
           
             1146 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1146
augccugaug gcaugcacua ugcgcgaucu acaucan                              37
 
           
             1147 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1147
guucaugaug gcaugcacua ugcgcgauaa agguaan                              37
 
           
             1148 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1148
uaaacugaug gcaugcacua ugcgcgauuc aaaguun                              37
 
           
             1149 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1149
acaaaugaug gcaugcacua ugcgcgaugu uaaugcn                              37
 
           
             1150 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1150
ugcuaugaug gcaugcacua ugcgcgauuc uuccacn                              37
 
           
             1151 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1151
ucugcugaug gcaugcacua ugcgcgauau ucuuccn                              37
 
           
             1152 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1152
uacaaugaug gcaugcacua ugcgcgauac gucugcn                              37
 
           
             1153 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1153
gggaaugaug gcaugcacua ugcgcgauuc acucaan                              37
 
           
             1154 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1154
auuccugaug gcaugcacua ugcgcgaugc agugugn                              37
 
           
             1155 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1155
caugcugaug gcaugcacua ugcgcgaucc aguauun                              37
 
           
             1156 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1156
gaauuugaug gcaugcacua ugcgcgaugc uauccan                              37
 
           
             1157 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1157
acagcugaug gcaugcacua ugcgcgauuc aguuucn                              37
 
           
             1158 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1158
aucauugaug gcaugcacua ugcgcgaucc caaacan                              37
 
           
             1159 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1159
ccuauugaug gcaugcacua ugcgcgauua ucccaan                              37
 
           
             1160 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1160
cucaaugaug gcaugcacua ugcgcgauaa cugcagn                              37
 
           
             1161 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1161
augugugaug gcaugcacua ugcgcgaugu uucagun                              37
 
           
             1162 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1162
cugcaugaug gcaugcacua ugcgcgauga cccacan                              37
 
           
             1163 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1163
cacugugaug gcaugcacua ugcgcgauau gacccan                              37
 
           
             1164 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1164
accaaugaug gcaugcacua ugcgcgauuc cuaggun                              37
 
           
             1165 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1165
uuugaugaug gcaugcacua ugcgcgauga ccaacan                              37
 
           
             1166 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1166
cagcaugaug gcaugcacua ugcgcgauac uccuaun                              37
 
           
             1167 
             56 
             DNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Selection
      Primer 1 
             
           
            1167
tggtgcaagc ttaatacgac tcactatagg gagactgtct agatcatgag gatgct         56
 
           
             1168 
             59 
             DNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Selection
      Primer 2 
             
           
            1168
tctcggatcc tgcagatcat nnnnnnnnnn nnnnnnnnnn nnaggattag catcctcat      59
 
           
             1169 
             20 
             DNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Reverse
      transcription primer 
             
           
            1169
tctcggatcc tgcagatcat                                                 20
 
           
             1170 
             23 
             DNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  PCR primer 
             
           
            1170
tggtgcaagc ttaatacgac tca                                             23
 
           
             1171 
             11 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Miscellaneous substrate 
             
           
            1171
nnnnuhnnnn n                                                          11
 
           
             1172 
             28 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1172
nnnnncugan gagnnnnnnc gaaannnn                                        28
 
           
             1173 
             47 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1173
agaucgucnn nngucuaauc cucugaugag cgcaagcgaa acgaucu                   47
 
           
             1174 
             51 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1174
agaucaugag gagucuaauc cunnnnnnnn nnnnnnnnnn nnnnaugauc u              51
 
           
             1175 
             69 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1175
gggagacugu cuagaucaug aggagucuaa uccunnnnnn nnnnnnnnnn nnnnnnauga     60
ucugcagga                                                             69
 
           
             1176 
             18 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1176
cugaugagcg caagcgaa                                                   18
 
           
             1177 
             22 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1177
ggaaucagcc ugacaccggc cc                                              22
 
           
             1178 
             22 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1178
ggcauccccg gcauggugcg cg                                              22
 
           
             1179 
             22 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1179
agcauuaccc ggcuggugcg cg                                              22
 
           
             1180 
             22 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1180
gcaucacggg gcaaucugcg cg                                              22
 
           
             1181 
             22 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1181
agcaucaccc ggauggugcg cg                                              22
 
           
             1182 
             22 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1182
agcaucaccc ggcuggugcg cg                                              22
 
           
             1183 
             22 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1183
abcguccacg gcaucgagcg cg                                              22
 
           
             1184 
             21 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1184
ugauggcuug cacuaagcgc g                                               21
 
           
             1185 
             21 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1185
ugauggcaug cacuaugcgc g                                               21
 
           
             1186 
             21 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1186
ugauggcaug caggaugcgc g                                               21
 
           
             1187 
             21 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1187
ugauggcaug caccaugcgc g                                               21
 
           
             1188 
             21 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1188
ugaucggaug caccaugcgc g                                               21
 
           
             1189 
             21 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence
      Self-cleaving Enzymatic Nucleic Acid 
             
           
            1189
ugggccgauc gcaagggcgc g                                               21
 
           
             1190 
             75 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1190
gggagacugu cuagaucaug aggaugcuaa uccuugaugg caugcacuau gcgcgaugau     60
cugcaggauc cgaga                                                      75
 
           
             1191 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1191
auccuugaug gcaugcacua ugcgcgauga ucugca                               36
 
           
             1192 
             16 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Substrate
      Nucleic Acid for SEQ ID NO 1191 
             
           
            1192
ugcagaucau gaggau                                                     16
 
           
             1193 
             35 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1193
auccuugaug gcaugcacua ugcgcgauga cgcug                                35
 
           
             1194 
             15 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Substrate
      Nucleic Acid for SEQ ID NO 1193 
             
           
            1194
cagcgucaug aggau                                                      15
 
           
             1195 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1195
auccuugaug gcaugcacua ugcgcgauga cgcuga                               36
 
           
             1196 
             16 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Substrate
      Nucleic Acid for SEQ ID NO 1195 
             
           
            1196
ucagcgucau gaggau                                                     16
 
           
             1197 
             29 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1197
cccuugaugg caugcacuau gcgcgauga                                       29
 
           
             1198 
             9 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Substrate
      Nucleic Acid for SEQ ID NO 1197 
             
           
            1198
ucaugaggg                                                              9
 
           
             1199 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1199
auccuugaug gcaugcacua ugcgcgauga cgcugan                              37
 
           
             1200 
             16 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Substrate
      Nucleic Acid for SEQ ID NO 1199 
             
           
            1200
ucagcgucau gaggau                                                     16
 
           
             1201 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1201
auccuugaug gcaugcacua ugcgcgauga cgcugan                              37
 
           
             1202 
             16 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Substrate
      Nucleic Acid for SEQ ID NO 1201 
             
           
            1202
ucagcgucau gaggau                                                     16
 
           
             1203 
             36 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1203
auccuugaug gcaugcacua ugcgcgauga cgcuga                               36
 
           
             1204 
             16 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Substrate
      Nucleic Acid for SEQ ID NO 1203 
             
           
            1204
ucagcgucau gaggau                                                     16
 
           
             1205 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1205
auccuugaug gcaugcacua ugcgcgauga cgcugan                              37
 
           
             1206 
             16 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Substrate
      Nucleic Acid for SEQ ID NO 1205 
             
           
            1206
ucagcgucau gaggau                                                     16
 
           
             1207 
             37 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Enzymatic
      Nucleic Acid 
             
           
            1207
nnnnuugaug gcaugcacua ugcgcgannn nnnnnnn                              37
 
           
             1208 
             16 
             RNA 
             Artificial Sequence 
             
               Description of Artificial Sequence  Substrate
      Nucleic Acid for SEQ ID NO 1207 
             
           
            1208
nnnnnnnnnu gannnn                                                     16