Patent Publication Number: US-2023150924-A1

Title: Novel compound having cancer metastasis inhibitory activity, preparation method therefor, and pharmaceutical composition for inhibiting cancer metastasis and invasion or treating colorectal cancer, comprising compound

Description:
TECHNICAL FIELD 
     The present invention provides a novel compound having cancer metastasis inhibitory activity, and a composition for inhibiting cancer metastasis and invasion or treating colorectal cancer containing the same. 
     BACKGROUND ART 
     The number of cancer (malignant neoplasm) deaths in Korea in 2002 was 62,887, which accounts for 25.5% (29.6% of male deaths, and 20.5% of female deaths) of the total number of deaths (246,515) in Korea in 2002, and cancer is the first leading cause of death in Korea. This means that about 131 people per 100,000 people in Korea die from cancer (2002 Statistics Korea). From the viewpoint of cancer treatment, one of the biggest reasons that the mortality rate of cancer patients cannot be reduced is that the invasion and metastasis of cancer cells cannot be suppressed in the process of malignancy. Recent studies have merely elucidated the molecular mechanism of the cancer metastasis process by identifying cancer metastasis-related genes (e.g., Twist, KAI1, etc.). Therefore, drugs or treatment methods capable of effectively inhibiting or preventing cancer metastasis using these cancer metastasis-related genes have not yet been reported. In the case of the United States, recent statistical analysis results show that the five-year survival rate for metastatic cancer has not improved for the past 20-30 years. 
     In this regard, KAI1 (Kangai 1) was initially identified as a metastatic suppressor in prostate carcinoma. The KAI1 protein is located on human chromosome 11p11 and belongs to the transmembrane 4 superfamily (TM4SF). KAI1 can regulate signal transduction from cell to cell and from cell to extracellular matrix (ECM), and may be involved in several basic biological processes such as fusion, migration, adhesion, mutation and invasion. Reduced or deleted expression of KAI1 has been demonstrated to be associated with metastasis and prognosis of various carcinomas, including laryngeal, prostate, breast, lung, gastric, colorectal and hepatocellular carcinomas. 
     Currently, as a method of treating cancer, surgery, chemotherapy, radiation therapy, etc. are used for cancer detected at an early stage, but the side effects thereof are also emerging as a big problem, and at the time when primary tumors are detected, metastases thereof are found in most cases. In addition, in the case of terminal cancer or metastatic cancer, there is no special treatment, and thus the patient dies within a limited period of time. Accordingly, to develop a new approach for cancer treatment, studies have been conducted to develop carcinogenic inhibitors and cancer treatment agents, which have few side effects and are highly effective in inhibiting or reducing metastasis of cancer, from natural products with relatively low toxicity. 
     DISCLOSURE 
     Technical Problem 
     Under this background, the present inventors have made extensive research efforts to discover novel small molecule compounds capable of inhibiting cancer metastasis, particularly colorectal cancer metastasis, and as a result, have found that novel compounds according to the present invention may exhibit excellent cancer metastasis inhibitory activity by efficiently increasing the activity of the KAI1 promoter gene, thereby completing the present invention. 
     Technical Solution 
     To achieve the above, one embodiment of the present invention provides a compound represented by the following Formula 1 or a pharmaceutically acceptable salt thereof: 
     
       
         
         
             
             
         
       
     
     wherein 
     X is C or N; 
     L is C1 to C4 alkylene or a bond; 
     R 1  is hydrogen, halogen, substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted C1-C4 alkoxy, di(C1-C4 alkyl)amino, mono(C1-C4 alkyl)amino, amino, or substituted or unsubstituted 5- to 12-membered heterocycle, 
     wherein the substituent of the substituted alkyl may be: amino unsubstituted or substituted with one or two substituents selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C6-C9 aryl, benzyl, hydroxy-C1-C6 alkyl and C3-C8 cycloalkyl; or a 5- to 12-membered heterocycle or heteroaryl unsubstituted or substituted with one or two substituents selected from the group consisting of C1-C4 alkyl, C1-C4 alkoxycarbonyl, C6-C9 aryl unsubstituted or substituted with one or two substituents selected from the group consisting of C1-C4 alkyl, C1-C4 alkoxy, halogen and nitro, and 5- to 10-membered heterocycles or heteroaryls; 
     R 2  is 
     
       
         
         
             
             
         
       
     
     R 3  is at least one selected from the group consisting of hydrogen, halogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C1-C6 alkoxy, substituted or unsubstituted 5- to 9-membered heteroaryl, substituted or unsubstituted C6-C10 aryl, substituted or unsubstituted C6-C10 aryloxy, substituted or unsubstituted 5- to 9-membered heterocyclyl, substituted or unsubstituted 5- to 9-membered heterocyclyloxy, nitro, 
     
       
         
         
             
             
         
       
     
     and —O—CH 2 —C(O)—NH—R 5 ; 
     R 4  hydrogen; halogen; C1-C6 alkyl unsubstituted or substituted with C1-C4 alkoxy, phenoxy or phenyl, wherein the phenyl may be unsubstituted or substituted with halogen; C2-C6 alkenyl; amino; di(C1-C4 alkyl)amino; C6-C9 aryl unsubstituted or substituted with at least one selected from the group consisting of halogen, C1-C4 alkoxy, C1-C4 alkyl unsubstituted or substituted with at least one halogen, nitro, C1-C4 alkylcarbonyloxy, and —SO 2 ; C3-C8 cycloalkyl; or 5- to 9-membered heterocyclyl; 
     R 5  is at least one (one or two) selected from the group consisting of hydrogen, halogen, hydroxy, substituted or unsubstituted C1-C4 alkyl, nitro, and C6-C10 aryloxy; and 
     n is an integer ranging from 0 to 2, preferably an integer ranging from 0 to 1. 
     Preferably, the substituent of the substituted C1-C6 alkyl, substituted C2-C6 alkenyl, substituted C3-C8 cycloalkyl, substituted C1-C6 alkoxy, substituted 5- to 9-membered heteroaryl, substituted C6-C10 aryl, substituted C6-C10 aryloxy, substituted 5- to 9-membered heterocyclyl, or substituted 5- to 9-membered heterocyclyloxy of R 3  may be at least one selected from the group consisting of C1-C4 alkoxy, C6-C9 aryl and C6-C9 aryloxy, and more preferably, may be at least one selected from the group consisting of phenyl, methoxy and phenoxy. 
     Advantageous Effects 
     The compound or pharmaceutically acceptable salt thereof according to the present invention may efficiently increase the activity of the KAI1 promoter gene by significantly increasing the activity of the KAI1 promoter, thereby exhibiting an excellent activity of inhibiting cancer metastasis and invasion or treating colorectal cancer. Thus, it is useful as an inhibitor of cancer metastasis and invasion and as a cancer therapeutic agent. 
    
    
     BEST MODE 
     Hereinafter, the present invention will be described in more detail. 
     The definition of each substituent used herein will be described in detail. Unless otherwise specified, each substituent has the following definition. 
     In the present specification, examples of “halogen” include fluoro, chloro, bromo and iodo. 
     As used herein, the term “alkyl” refers to a linear or branched aliphatic saturated hydrocarbon group, preferably an alkyl having 1 to 6 carbon atoms, more preferably an alkyl having 1 to 4 carbon atoms. Examples of such alkyl include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, 1-ethylpropyl, hexyl, isohexyl, 1,1-dimethylbutyl, 2,2-dimethylbutyl, 3,3-dimethylbutyl, and 2-ethylbutyl. 
     As used herein, the term “heterocycle” refers to a non-aromatic ring containing, a ring constituent atom, a heteroatom selected from a nitrogen atom, a sulfur atom and an oxygen atom other than a carbon atom, and preferably includes a 5- to 12-membered non-aromatic ring containing 1 to 4 heteroatoms. Examples of this non-aromatic ring include tetrahydrothienyl, tetrahydrofuranyl, pyrrolinyl, pyrrolidinyl, imidazolinyl, imidazolidinyl, oxazolinyl, oxazolidinyl, pyrazolinyl, pyrazolidinyl, thiazolinyl, thiazolidinyl, tetrahydroisothiazolyl, tetrahydrooxazolyl, tetrahydroisoxazolyl, piperidinyl, piperazinyl, tetrahydropyridinyl, dihydropyridinyl, dihydrothiopyranyl, tetrahydropyrimidinyl, tetrahydropyridazinyl, dihydropyranyl, tetrahydropyranyl, tetrahydrothiopyranyl, morpholinyl, thiomorpholinyl, azepanyl, diazepanyl, and azepinyl. 
     As used herein, the term “heteroaryl” refers to an aromatic ring containing, as a ring constituent atom, a heteroatom selected from among a nitrogen atom, a sulfur atom and an oxygen atom other than a carbon atom, and preferably includes a 5- to 12-membered aromatic ring containing 1 to 4 hetero atoms. Examples of this aromatic ring include thienyl, furyl, pyrrolyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1,3,4-thiadiazolyl, triazolyl, tetrazolyl, indenyl, triazinyl, and dihydroisoquinolinyl. 
     In a preferred embodiment, in the compound of Formula 1, 
     X is C or N; 
     L is C1 to C4 alkylene or a bond; 
     R 1  is hydrogen, F, Cl, Br, substituted or unsubstituted C1-C4 alkyl, methoxy, N(CH 3 ) 2 , NH(CH 3 ), amino, or a substituted or unsubstituted 5 to 12-membered heterocycle, 
     wherein the substituent of the substituted alkyl may be unsubstituted or substituted with dimethylamino, diethylamino, dipropylamino, dibutylamino, hydroxyethyl(ethyl)amino, ethyl(butyl)amino, dipentylamino, methyl(ethynyl)amino, ethyl(phenyl)amino, diallylamino, methyl(benzyl)amino, methyl(hydroxyethyl)amino, phenyl(methyl)amino, ethyl(phenyl)amino, butyl(hydroxyethyl)amino, butyl(methyl)amino, dicyclohexylamino, ethoxycarbonyl-piperazine, t-butoxycarbonyl-piperazine, fluorophenyl-piperidine, pyridinyl-piperazine, pyrimidinyl-piperazine, hydroxyethylpiperazine, methoxyphenyl-piperazine, nitrophenyl-piperazine, dimethylmorpholine, morpholine, methylpiperazine, dihydroxyisoquinoline, cyclohexyl(methyl)amino, isopropyl(methyl)amino, fluorophenyl-piperazine, or piperidinylpiperidine; 
     
       
         
         
             
             
         
       
     
     R 3  is at least one selected from the group consisting of hydrogen, F, Cl, Br, substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted C2-C4 alkenyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C1-C4 alkoxy, substituted or unsubstituted 5- to 9-membered heteroaryl, substituted or unsubstituted C6-C10 aryl, substituted or unsubstituted C6-C10 aryloxy, substituted or unsubstituted 5- to 9-membered heterocyclyl, substituted or unsubstituted 5- to 9-membered heterocyclyloxy, nitro, 
     
       
         
         
             
             
         
       
     
     and —O—CH 2 —C(O)—NH—R 5 ; 
     R 4  is hydrogen; F, Cl, Br; C1-C4 unsubstituted or substituted with methoxy, ethoxy, phenoxy or phenyl, wherein the phenyl may be unsubstituted or substituted with halogen; C2-C4 alkenyl; amino; di(C1-C4 alkyl)amino; C6-C9 aryl unsubstituted or substituted with at least one selected from the group consisting of halogen, C1-C3 alkoxy, C1-C4 alkyl unsubstituted or substituted with at least one halogen, nitro, C1-C3 alkylcarbonyloxy, and —SO 2 ; C3-C8 cycloalkyl; or 5- to 9-membered heterocyclyl; 
     R 5  is at least one (one or two) selected from the group consisting of hydrogen, halogen, hydroxy, substituted or unsubstituted C1-C4 alkyl, nitro, and C6-C10 aryloxy; and 
     n is an integer ranging from 0 to 2, preferably an integer ranging from 0 to 1. 
     Preferably, the substituent of the substituted C1-C4 alkyl, substituted C2-C4 alkenyl, substituted C3-C8 cycloalkyl, substituted C1-C4 alkoxy, substituted 5- to 9-membered heteroaryl, substituted C6-C10 aryl, substituted C6-C10 aryloxy, substituted 5- to 9-membered heterocyclyl, or substituted 5- to 9-membered heterocyclyloxy of R 3  may be at least one selected from the group consisting of C1-C4 alkoxy, C6-C9 aryl and C6-C9 aryloxy, and more preferably, may be at least one selected from the group consisting of phenyl, methoxy and phenoxy. 
     In a specific embodiment, examples of the compound include compounds 1 to 305 shown in Table 1 below. 
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 1 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                 Quanti- 
                 DMSO 
               
               
                 No. 
                 Code 
                 Structure 
                 MW 
                 ty (mg) 
                 (ul) 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1 
                 DKC25a01 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 273.72 
                 1.1 mg 
                 402 
               
               
                   
               
               
                 2 
                 DKC25a02 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 283.33 
                 0.9 mg 
                 318 
               
               
                   
               
               
                 3 
                 DKC25a03 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 257.26 
                 1.3 mg 
                 505 
               
               
                   
               
               
                 4 
                 DKC25a04 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 257.26 
                 1.5 mg 
                 583 
               
               
                   
               
               
                 5 
                 DKC25a05 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 229.24 
                 1.3 mg 
                 567 
               
               
                   
               
               
                 6 
                 DKC25a06 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 273.72 
                 1.4 mg 
                 511 
               
               
                   
               
               
                 7 
                 DKC25a07 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 273.72 
                 1.2 mg 
                 438 
               
               
                   
               
               
                 8 
                 DKC25a08 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 203.24 
                 1.2 mg 
                 590 
               
               
                   
               
               
                 9 
                 DKC25a09 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 267.33 
                 1.0 mg 
                 374 
               
               
                   
               
               
                 10 
                 DKC25a10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 189.21 
                 1.2 mg 
                 634 
               
               
                   
               
               
                 11 
                 DKC25a11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 253.30 
                 0.8 mg 
                 316 
               
               
                   
               
               
                 12 
                 DKC25a12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 269.30 
                 1.5 mg 
                 557 
               
               
                   
               
               
                 13 
                 DKC25a13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 253.30 
                 1.2 mg 
                 474 
               
               
                   
               
               
                 14 
                 DKC25a14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 191.23 
                 1.4 mg 
                 732 
               
               
                   
               
               
                 15 
                 DKC25a15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 245.32 
                 0.8 mg 
                 326 
               
               
                   
               
               
                 16 
                 DKC25a16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 203.24 
                 1.7 mg 
                 836 
               
               
                   
               
               
                 17 
                 DKC25a17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 217.27 
                 1.7 mg 
                 782 
               
               
                   
               
               
                 18 
                 DKC25a18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 245.30 
                 1.4 mg 
                 571 
               
               
                   
               
               
                 19 
                 DKC25a19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 233.31 
                 1.0 mg 
                 429 
               
               
                   
               
               
                 20 
                 DKC25a20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 219.28 
                 1.0 mg 
                 456 
               
               
                   
               
               
                 21 
                 DKC25a21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 320.32 
                 1.3 mg 
                 406 
               
               
                   
               
               
                 22 
                 DKC25a22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 275.25 
                 0.9 mg 
                 327 
               
               
                   
               
               
                 23 
                 DKC25a23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 207.23 
                 1.2 mg 
                 579 
               
               
                   
               
               
                 24 
                 DKC25a24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 219.28 
                 1.2 mg 
                 547 
               
               
                   
               
               
                 25 
                 DKC25a25 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 213.25 
                 0.9 mg 
                 422 
               
               
                   
               
               
                 26 
                 DKC25a26 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 293.31 
                 1.3 mg 
                 443 
               
               
                   
               
               
                 27 
                 DKC25a27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 289.35 
                 1.1 mg 
                 380 
               
               
                   
               
               
                 28 
                 DKC25a28 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 289.35 
                 1.7 mg 
                 588 
               
               
                   
               
               
                 29 
                 DKC25a29 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 375.27 
                 1.1 mg 
                 293 
               
               
                   
               
               
                 30 
                 DKC25a30 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 307.27 
                 1.4 mg 
                 456 
               
               
                   
               
               
                 31 
                 DKC25a31 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 307.27 
                 1.4 mg 
                 456 
               
               
                   
               
               
                 32 
                 DKC25a32 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 307.27 
                 1.1 mg 
                 358 
               
               
                   
               
               
                 33 
                 DKC25a33 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 291.71 
                 1.2 mg 
                 411 
               
               
                   
               
               
                 34 
                 DKC25a34 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 284.27 
                 1.0 mg 
                 352 
               
               
                   
               
               
                 35 
                 DKC25a35 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 275.25 
                 1.5 mg 
                 545 
               
               
                   
               
               
                 36 
                 DKC25a36 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 308.16 
                 0.9 mg 
                 292 
               
               
                   
               
               
                 37 
                 DKC25a37 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 308.16 
                 1.5 mg 
                 487 
               
               
                   
               
               
                 38 
                 DKC25a38 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 323.27 
                 1.4 mg 
                 433 
               
               
                   
               
               
                 39 
                 DKC25a39 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 323.27 
                 1.7 mg 
                 526 
               
               
                   
               
               
                 40 
                 DKC25a40 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 267.33 
                 1.4 mg 
                 524 
               
               
                   
               
               
                 41 
                 DKC25a41 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 323.27 
                 1.4 mg 
                 433 
               
               
                   
               
               
                 42 
                 DKC25a42 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 299.33 
                 1.4 mg 
                 468 
               
               
                   
               
               
                 43 
                 DKC25a43 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 315.37 
                 1.4 mg 
                 444 
               
               
                   
               
               
                 44 
                 DKC25b01 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 291.71 
                 1.3 mg 
                 446 
               
               
                   
               
               
                 45 
                 DKC25b02 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 291.71 
                 1.0 mg 
                 343 
               
               
                   
               
               
                 46 
                 DKC25b03 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 263.68 
                 1.1 mg 
                 417 
               
               
                   
               
               
                 47 
                 DKC25b04 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 308.16 
                 0.9 mg 
                 292 
               
               
                   
               
               
                 48 
                 DKC25b05 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 237.68 
                 1.0 mg 
                 421 
               
               
                   
               
               
                 49 
                 DKC25b06 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 301.77 
                 1.5 mg 
                 497 
               
               
                   
               
               
                 50 
                 DKC25b07 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 223.66 
                 1.7 mg 
                 760 
               
               
                   
               
               
                 51 
                 DKC25b08 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 287.74 
                 1.5 mg 
                 521 
               
               
                   
               
               
                 52 
                 DKC25b09 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 303.74 
                 1.4 mg 
                 461 
               
               
                   
               
               
                 53 
                 DKC25b10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 287.74 
                 1.2 mg 
                 417 
               
               
                   
               
               
                 54 
                 DKC25b11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 225.67 
                 1.3 mg 
                 576 
               
               
                   
               
               
                 55 
                 DKC25b12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 279.76 
                 0.9 mg 
                 322 
               
               
                   
               
               
                 56 
                 DKC25b13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 237.68 
                 0.9 mg 
                 379 
               
               
                   
               
               
                 57 
                 DKC25b14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 251.71 
                 1.0 mg 
                 397 
               
               
                   
               
               
                 58 
                 DKC25b15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 279.74 
                 1.5 mg 
                 536 
               
               
                   
               
               
                 59 
                 DKC25b16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 317.77 
                 1.0 mg 
                 315 
               
               
                   
               
               
                 60 
                 DKC25b17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 267.75 
                 12. mg 
                 448 
               
               
                   
               
               
                 61 
                 DKC25b18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 253.73 
                 1.1 mg 
                 434 
               
               
                   
               
               
                 62 
                 DKC25b19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 303.74 
                 1.0 mg 
                 329 
               
               
                   
               
               
                 63 
                 DKC25b20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 354.76 
                 1.0 mg 
                 282 
               
               
                   
               
               
                 61 
                 DKC25b21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 309.70 
                 1.6 mg 
                 517 
               
               
                   
               
               
                 65 
                 DKC25b22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 241.67 
                 1.0 mg 
                 414 
               
               
                   
               
               
                 66 
                 DKC25b23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 253.73 
                 1.2 mg 
                 473 
               
               
                   
               
               
                 67 
                 DKC25b24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 327.75 
                 1.4 mg 
                 427 
               
               
                   
               
               
                 68 
                 DKC25b25 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 323.79 
                 1.1 mg 
                 340 
               
               
                   
               
               
                 69 
                 DKC25b26 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 344.21 
                 1.7 mg 
                 494 
               
               
                   
               
               
                 73 
                 DKC25b27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 323.79 
                 1.6 mg 
                 494/ 
               
               
                   
               
               
                 71 
                 DKC25b28  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 339.79 
                 1.6 mg 
                 471 
               
               
                   
               
               
                 72 
                 DKC25b29 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 409.71 
                 1.7 mg 
                 415 
               
               
                   
               
               
                 73 
                 DKC25b30 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 341.71 
                 1.5 mg 
                 439 
               
               
                   
               
               
                 74 
                 DKC25b31 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 341.71 
                 1.1 mg 
                 322 
               
               
                   
               
               
                 75 
                 DKC25b32 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 341.71 
                 1.2 mg 
                 351 
               
               
                   
               
               
                 76 
                 DKC25b33 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 326.15 
                 1.5 mg 
                 460 
               
               
                   
               
               
                 77 
                 DKC25b34 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 317.71 
                 1.7 mg 
                 533 
               
               
                   
               
               
                 78 
                 DKC25b35 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 309.70 
                 0.8 mg 
                 258 
               
               
                   
               
               
                 79 
                 DKC25b36  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 342.60 
                 1.2 mg 
                 350 
               
               
                   
               
               
                 80 
                 DKC25b37 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 342.60 
                 1.5 mg 
                 438 
               
               
                   
               
               
                 81 
                 DKC25b38 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 357.71 
                 1.1 mg 
                 308 
               
               
                   
               
               
                 82 
                 DKC25b39 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 357.71 
                 1.5 mg 
                 419 
               
               
                   
               
               
                 83 
                 DKC25b40 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 301.77 
                 1.0 mg 
                 331 
               
               
                   
               
               
                 84 
                 DKC25b41 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 357.71 
                 1.5 mg 
                 419 
               
               
                   
               
               
                 85 
                 DKC25b42 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 333.77 
                 0.8 mg 
                 240 
               
               
                   
               
               
                 86 
                 DKC25b43 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 349.81 
                 1.0 mg 
                 286 
               
               
                   
               
               
                 87 
                 DKC25b44 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 308.16 
                 1.0 mg 
                 325 
               
               
                   
               
               
                 88 
                 DKC25c01 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 316.79 
                 1.4 mg 
                 442 
               
               
                   
               
               
                 81 
                 DKC25b38 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 357.71 
                 1.1 mg 
                 308 
               
               
                   
               
               
                 82 
                 DKC25b39 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 357.71 
                 1.5 mg 
                 419 
               
               
                   
               
               
                 83 
                 DKC25b40 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 301.77 
                 1.6 mg 
                 331 
               
               
                   
               
               
                 84 
                 DKC25b41 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 357.71 
                 1.5 mg 
                 419 
               
               
                   
               
               
                 85 
                 DKC25b42 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 333.77 
                 0.8 mg 
                 240 
               
               
                   
               
               
                 86 
                 DKC25b43 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 369.81 
                 1.0 mg 
                 286 
               
               
                   
               
               
                 87 
                 DKC25b44 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 303.16 
                 1.0 mg 
                 325 
               
               
                   
               
               
                 88 
                 DKC25c01 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 316.79 
                 1.6 mg 
                 442 
               
               
                   
               
               
                 96 
                 DKC25c09 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 296.37 
                 0.9 mg 
                 304 
               
               
                   
               
               
                 97 
                 DKC25c10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 312.37 
                 0.8 mg 
                 256 
               
               
                   
               
               
                 98 
                 DKC25c11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 296.37 
                 1.4 mg 
                 472 
               
               
                   
               
               
                 99 
                 DLC25c12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 234.30 
                 1.0 mg 
                 427 
               
               
                   
               
               
                 100 
                 DKC25c13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 246.31 
                 0.9 mg 
                 365 
               
               
                   
               
               
                 101 
                 DKC25c14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 288.37 
                 1.0 mg 
                 347 
               
               
                   
               
               
                 102 
                 DKC25c15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 276.38 
                 1.4 mg 
                 507 
               
               
                   
               
               
                 103 
                 DKC25c16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 262.35 
                 1.1 mg 
                 419 
               
               
                   
               
               
                 104 
                 DKC25c17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 312.37 
                 1.0 mg 
                 320 
               
               
                   
               
               
                 105 
                 DKC25c18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 318.32 
                 1.0 mg 
                 314 
               
               
                   
               
               
                 106 
                 DKC25c19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 250.30 
                 1.5 mg 
                 599 
               
               
                   
               
               
                 107 
                 DKC25c20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 336.38 
                 1.1 mg 
                 327 
               
               
                   
               
               
                 108 
                 DKC25c21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 352.83 
                 1.2 mg 
                 340 
               
               
                   
               
               
                 109 
                 DKC25c22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 318.39 
                 0.9 mg 
                 283 
               
               
                   
               
               
                 110 
                 DKC25c23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 332.42 
                 0.9 mg 
                 271 
               
               
                   
               
               
                 111 
                 DKC25c24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 348.42 
                 1.9 mg 
                 545 
               
               
                   
               
               
                 112 
                 DKC25c25 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 350.34 
                 1.3 mg 
                 371 
               
               
                   
               
               
                 113 
                 DKC25c26 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 350.34 
                 1.0 mg 
                 285 
               
               
                   
               
               
                 114 
                 DKC25c27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 350.34 
                 1.4 mg 
                 400 
               
               
                   
               
               
                 115 
                 DKC25c28 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 334.78 
                 1.0 mg 
                 299 
               
               
                   
               
               
                 116 
                 DKC25c29 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 318.32 
                 1.2 mg 
                 377 
               
               
                   
               
               
                 117 
                 DKC25c30 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 351.23 
                 0.8 mg 
                 228 
               
               
                   
               
               
                 118 
                 DKC25c31 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 351.23  
                 1.3 mg 
                 370 
               
               
                   
               
               
                 119 
                 DKC25c32 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 366.34 
                 1.0 mg 
                 273 
               
               
                   
               
               
                 120 
                 DKC25c33 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 310.40 
                 1.0 mg 
                 322 
               
               
                   
               
               
                 121 
                 DKC25c34 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 342.40 
                 1.1 mg 
                 321 
               
               
                   
               
               
                 122 
                 DKC25d01 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 303.74 
                 1.2 mg 
                 395 
               
               
                   
               
               
                 123 
                 DKC25d02 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 233.27 
                 0.8 mg 
                 343 
               
               
                   
               
               
                 124 
                 DKC25d03 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 221.26 
                 1.4 mg 
                 633 
               
               
                   
               
               
                 125 
                 DKC25d04 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 233.27 
                 1.7 mg 
                 729 
               
               
                   
               
               
                 126 
                 DKC25d05 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 247.29 
                 1.2 mg 
                 485 
               
               
                   
               
               
                 127 
                 DKC25d06 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 275.32 
                 1.4 mg 
                 508 
               
               
                   
               
               
                 128 
                 DKC25d07 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 249.31 
                 1.5 mg 
                 602 
               
               
                   
               
               
                 129 
                 DKC25d08 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 305.35 
                 1.3 mg 
                 426 
               
               
                   
               
               
                 130 
                 DKC25e01 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 274.70 
                 1.0 mg 
                 364 
               
               
                   
               
               
                 131 
                 DKC25e02 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 284.32 
                 0.9 mg 
                 317 
               
               
                   
               
               
                 132 
                 DKC25e03 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 258.25 
                 1.0 mg 
                 387 
               
               
                   
               
               
                 133 
                 DKC25e04 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 258.25 
                 0.8 mg 
                 310 
               
               
                   
               
               
                 134 
                 DKC25e05 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 204.23 
                 1.1 mg 
                 539 
               
               
                   
               
               
                 135 
                 DKC25e06 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 254.29 
                 1.1 mg 
                 433 
               
               
                   
               
               
                 136  
                 DKC25e07 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 192.22 
                 1.0 mg 
                 520 
               
               
                   
               
               
                 137 
                 DKC25f01  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 342.37 
                 1.13 mg 
                 380 
               
               
                   
               
               
                 138 
                 DKC25f02 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 358.82 
                 1.4 mg 
                 390 
               
               
                   
               
               
                 139 
                 DKC25f03 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 288.35 
                 0.9 mg 
                 312 
               
               
                   
               
               
                 140 
                 DKC25f04 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 354.41 
                 0.7 mg 
                 198 
               
               
                   
               
               
                 141 
                 DKC25f05 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 338.41 
                 1.0 mg 
                 295 
               
               
                   
               
               
                 142 
                 DKC25f06 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 376.34 
                 0.5 mg 
                 133 
               
               
                   
               
               
                 143 
                 DKC25f07 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 288.35 
                 0.8 mg 
                 277 
               
               
                   
               
               
                 144 
                 DKC25f08 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 302.37 
                 0.9 mg 
                 298 
               
               
                   
               
               
                 145 
                 DKC25f09 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 304.39 
                 0.8 mg 
                 263 
               
               
                   
               
               
                 146 
                 DKC25f10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 378.42 
                 0.9 mg 
                 238 
               
               
                   
               
               
                 147 
                 DKC25f11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 394.87 
                 1.0 mg 
                 253 
               
               
                   
               
               
                 148 
                 DKC25f12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 360.43 
                 0.8 mg 
                 222 
               
               
                   
               
               
                 149 
                 DKC25f13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 374.46 
                 1.5 mg 
                 401 
               
               
                   
               
               
                 150 
                 DKC25f14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 390.45 
                 1.1 mg 
                 282 
               
               
                   
               
               
                 151 
                 DKC25g01 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 476.15 
                 1.4 mg 
                 294 
               
               
                   
               
               
                 152 
                 DKC25g02 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 486.22 
                 1.1 mg 
                 226 
               
               
                   
               
               
                 153 
                 DKC25g03 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 460.18 
                 1.2 mg 
                 261 
               
               
                   
               
               
                 154 
                 DKC25g04 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 460.18 
                 1.4 mg 
                 304 
               
               
                   
               
               
                 155 
                 DKC25g05 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 432.17 
                 0.9 mg 
                 208 
               
               
                   
               
               
                 156 
                 DKC25g06 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 476.15 
                 0.9 mg 
                 189 
               
               
                   
               
               
                 157 
                 DMC25g07 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 476.15 
                 1.0 mg 
                 210 
               
               
                   
               
               
                 158 
                 DKC25g08 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 406.19 
                 1.4 mg 
                 345 
               
               
                   
               
               
                 159 
                 DKC25g09 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 470.10 
                 0.9 mg 
                 191 
               
               
                   
               
               
                 160 
                 DKC25g10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 392.00 
                 1.0 mg 
                 255 
               
               
                   
               
               
                 161 
                 DKC25g11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 456.20 
                 0.9 mg 
                 197 
               
               
                   
               
               
                 162 
                 DKC25g12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 472.20 
                 1.0 mg 
                 212 
               
               
                   
               
               
                 163 
                 DKC25g13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 456.20 
                 1.0 mg 
                 219 
               
               
                   
               
               
                 164 
                 DKC25g14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 394.00 
                 1.1 mg 
                 279 
               
               
                   
               
               
                 165 
                 DKC25g15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 448.24 
                 0.9 mg 
                 201 
               
               
                   
               
               
                 166 
                 DKC25g16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 406.19 
                 1.4 mg 
                 345 
               
               
                   
               
               
                 167 
                 DKC25g17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 420.20 
                 1.2 mg 
                 286 
               
               
                   
               
               
                 168 
                 DKC25g18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 448.15 
                 1.3 mg 
                 290 
               
               
                   
               
               
                 169 
                 DKC25g19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 486.20 
                 1.4 mg 
                 288 
               
               
                   
               
               
                 170 
                 DKC25g20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 436.24 
                 1.2 mg 
                 275 
               
               
                   
               
               
                 171 
                 DKC25g21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 451.21 
                 1.0 mg 
                 222 
               
               
                   
               
               
                 172 
                 DKC25g22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 522.22 
                 1.2 mg 
                 230 
               
               
                   
               
               
                 173 
                 DKC25g23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 572.20 
                 1.4 mg 
                 245 
               
               
                   
               
               
                 174 
                 DKC25g24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 470.22 
                 1.4 mg 
                 298 
               
               
                   
               
               
                 175 
                 DKC25g25 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 541.11 
                 1.1 mg 
                 203 
               
               
                   
               
               
                 176 
                 DKC25g26 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 519.00 
                 1.2 mg 
                 231 
               
               
                   
               
               
                 177 
                 DKC25g27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 478.00 
                 0.9 mg 
                 188 
               
               
                   
               
               
                 178 
                 DKC25g28 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 410.00 
                 1.1 mg 
                 268 
               
               
                   
               
               
                 179 
                 DKC25g29 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 422.22 
                 1.3 mg 
                 308 
               
               
                   
               
               
                 180 
                 DKC25g30 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 409.20 
                 0.9 mg 
                 220 
               
               
                   
               
               
                 181 
                 DKC25g31 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 520.10 
                 0.9 mg 
                 173 
               
               
                   
               
               
                 182 
                 DKC25g32 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 380.17 
                 1.0 mg 
                 263 
               
               
                   
               
               
                 183 
                 DKC25g33 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 416.14 
                 1.4 mg 
                 336 
               
               
                   
               
               
                 184 
                 DKC25g34 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 496.15 
                 1.2 mg 
                 242 
               
               
                   
               
               
                 185 
                 DKC25g35  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 492.17 
                 1.1 mg 
                 224 
               
               
                   
               
               
                 186 
                 DKC25g36  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 512.12 
                 1.2 mg 
                 234 
               
               
                   
               
               
                 187 
                 DKC25g37 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 478.16 
                 1.2 mg 
                 251 
               
               
                   
               
               
                 188 
                 DKC25g38 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 492.17 
                 0.8 mg 
                 163 
               
               
                   
               
               
                 189 
                 DKC25g39 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 408.17 
                 1.4 mg 
                 343 
               
               
                   
               
               
                 190 
                 DKC25g40 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 578.16 
                 1.4 mg 
                 242 
               
               
                   
               
               
                 191 
                 DKC25g41 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 510.18 
                 1.4 mg 
                 274 
               
               
                   
               
               
                 192 
                 DKC25g42 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 510.18 
                 1.1 mg 
                 216 
               
               
                   
               
               
                 193 
                 DKC25g43 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 510.18 
                 1.4 mg 
                 274 
               
               
                   
               
               
                 194 
                 DKC25g44 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 494.14 
                 1.0 mg 
                 202 
               
               
                   
               
               
                 195 
                 DKC25g45 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 487.17 
                 1.4 mg 
                 287 
               
               
                   
               
               
                 196 
                 DKC25g46 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 478.17 
                 1.4 mg 
                 293 
               
               
                   
               
               
                 197 
                 DKC25g47 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 510.11 
                 1.3 mg 
                 255 
               
               
                   
               
               
                 198 
                 DKC25g48 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 510.11 
                 1.3 mg 
                 255 
               
               
                   
               
               
                 199 
                 DKC25g49 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 526.17 
                 1.4 mg 
                 266 
               
               
                   
               
               
                 200 
                 DKC25g50 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 526.17 
                 1.4 mg 
                 266 
               
               
                   
               
               
                 201 
                 DKC25h01 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 388.14 
                 1.2 mg 
                 309 
               
               
                   
               
               
                 202 
                 DKC25h02 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 402.16 
                 1.4 mg 
                 348 
               
               
                   
               
               
                 203 
                 DKC25h03 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 352.14 
                 0.9 mg 
                 256 
               
               
                   
               
               
                 204 
                 DKC25h04 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 402.16 
                 1.0 mg 
                 249 
               
               
                   
               
               
                 205 
                 DKC25h05 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 420.15 
                 0.8 mg 
                 190 
               
               
                   
               
               
                 206 
                 DKC25h06 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 432.17 
                 0.8 mg 
                 185 
               
               
                   
               
               
                 207 
                 DKC25h07 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 436.14 
                 1.4 mg 
                 321 
               
               
                   
               
               
                 208 
                 DKC25h08 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 389.14 
                 0.8 mg 
                 206 
               
               
                   
               
               
                 209 
                 DKC25h09 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 418.15 
                 1.4 mg 
                 335 
               
               
                   
               
               
                 210 
                 DKC25h10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 430.19 
                 1.4 mg 
                 325 
               
               
                   
               
               
                 211 
                 DKC25h11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 451.12 
                 1.4 mg 
                 310 
               
               
                   
               
               
                 212 
                 DKC25h12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 446.15 
                 1.4 mg 
                 314 
               
               
                   
               
               
                 213 
                 DKC25h13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 430.19 
                 1.4 mg 
                 325 
               
               
                   
               
               
                 214 
                 DKC25h14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 480.17 
                 1.4 mg 
                 292 
               
               
                   
               
               
                 215 
                 DKC25h15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 462.16 
                 1.4 mg 
                 303 
               
               
                   
               
               
                 216 
                 DKC25h16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 448.16 
                 1.5 mg 
                 335 
               
               
                   
               
               
                 217 
                 DKC25h17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 432.43 
                 1.4 mg 
                 324 
               
               
                   
               
               
                 218 
                 DKC25h18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 446.15 
                 1.4 mg 
                 314 
               
               
                   
               
               
                 219 
                 DKC25h19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 428.17 
                 0.9 mg 
                 210 
               
               
                   
               
               
                 220 
                 DKC25h20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 446.18 
                 1.0 mg 
                 224 
               
               
                   
               
               
                 221 
                 DKC25h21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 480.17 
                 1.3 mg 
                 271 
               
               
                   
               
               
                 222 
                 DKC25h22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 474.12 
                 0.8 mg 
                 169 
               
               
                   
               
               
                 223 
                 DKC25h23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 404.14 
                 0.9 mg 
                 223 
               
               
                   
               
               
                 224 
                 DKC25h24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 422.10 
                 1.2 mg 
                 284 
               
               
                   
               
               
                 225 
                 DKC25h25 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 466.05 
                 0.9 mg 
                 193 
               
               
                   
               
               
                 226 
                 DKC25h26 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 354.16 
                 1.0 mg 
                 282 
               
               
                   
               
               
                 227 
                 DKC25h27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 428.17 
                 1.4 mg 
                 327 
               
               
                   
               
               
                 228 
                 DKC25h28 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 354.16 
                 1.0 mg 
                 282 
               
               
                   
               
               
                 229 
                 DKC25h29 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 382.19 
                 0.8 mg 
                 209 
               
               
                   
               
               
                 230 
                 DKC25h30 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 394.19 
                 1.4 mg 
                 355 
               
               
                   
               
               
                 231 
                 DKC25i01 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 296.37 
                 1.9 mg 
                 641 
               
               
                   
               
               
                 232 
                 DKC25i02 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 384.48 
                 2.4 mg 
                 624 
               
               
                   
               
               
                 233 
                 DKC25i03 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 324.42 
                 1.6 mg 
                 493 
               
               
                   
               
               
                 234 
                 DKC25i04 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 430.52 
                 1.4 mg 
                 325 
               
               
                   
               
               
                 235 
                 DKC25i05 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 415.50 
                 1.8 mg 
                 433 
               
               
                   
               
               
                 236 
                 DKC25i06 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 443.55 
                 2.5 mg 
                 564 
               
               
                   
               
               
                 237 
                 DKC25i07 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 419.57 
                 2.0 mg 
                 477 
               
               
                   
               
               
                 238 
                 DKC25i08 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 458.52 
                 1.1 mg 
                 240 
               
               
                   
               
               
                 239 
                 DKC25i09 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 372.47 
                 2.2 mg 
                 591 
               
               
                   
               
               
                 240 
                 DKC25i10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 414.51 
                 1.2 mg 
                 289 
               
               
                   
               
               
                 241 
                 DKC25i11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 348.45 
                 1.8 mg 
                 517 
               
               
                   
               
               
                 242 
                 DKC25i12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 372.47 
                 1.9 mg 
                 510 
               
               
                   
               
               
                 243 
                 DKC25i13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 326.40 
                 1.7 mg 
                 521 
               
               
                   
               
               
                 244 
                 DKC25i14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 368.48 
                 2.0 mg 
                 543 
               
               
                   
               
               
                 245 
                 DKC25i15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 437.54 
                 2.3 mg 
                 526 
               
               
                   
               
               
                 246 
                 DKC25i16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 338.45 
                 1.3 mg 
                 384 
               
               
                   
               
               
                 247 
                 DKC25i17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 324.42 
                 1.7 mg 
                 524 
               
               
                   
               
               
                 248 
                 DKC25i18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 352.48 
                 1.5 mg 
                 426 
               
               
                   
               
               
                 249 
                 DKC25i19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 352.48 
                 1.0 mg 
                 284 
               
               
                   
               
               
                 250 
                 DKC25i20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 408.59 
                 1.6 mg 
                 392 
               
               
                   
               
               
                 251 
                 DKC25i21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 306.37 
                 1.1 mg 
                 359 
               
               
                   
               
               
                 252 
                 DKC25i22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 338.41 
                 1.6 mg 
                 473 
               
               
                   
               
               
                 253 
                 DKC25i23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 351.45 
                 1.7 mg 
                 484 
               
               
                   
               
               
                 254 
                 DKC25i24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 384.48 
                 1.3 mg 
                 338 
               
               
                   
               
               
                 255 
                 DKC25i25 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 364.49 
                 1.9 mg 
                 521 
               
               
                   
               
               
                 256 
                 DKC25i26 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 324.42 
                 2.3 mg 
                 709 
               
               
                   
               
               
                 257 
                 DKC25i17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 431.51 
                 2.2 mg 
                 510 
               
               
                   
               
               
                 258 
                 DKC25i28 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 415.50 
                 1.9 mg 
                 457 
               
               
                   
               
               
                 259 
                 DKC25i29 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 443.55 
                 1.8 mg 
                 406 
               
               
                   
               
               
                 260 
                 DKC25i30 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 419.57 
                 1.4 mg 
                 334 
               
               
                   
               
               
                 261 
                 DKC25i31 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 458.52 
                 2.5 mg 
                 545 
               
               
                   
               
               
                 262 
                 DKC25i32 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 358.44 
                 1.9 mg 
                 530 
               
               
                   
               
               
                 263 
                 DKC25i33 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 372.47 
                 1.9 mg 
                 510 
               
               
                   
               
               
                 264 
                 DKC25i34 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 414.51 
                 1.6 mg 
                 386 
               
               
                   
               
               
                 265 
                 DKC25i35 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 348.45 
                 1.8 mg 
                 517 
               
               
                   
               
               
                 266 
                 DKC25i36 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 372.47 
                 1.4 mg 
                 376 
               
               
                   
               
               
                 267 
                 DKC25i37 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 326.40 
                 2.1 mg 
                 643 
               
               
                   
               
               
                 268 
                 DKC25i38 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 368.48 
                 2.1 mg 
                 570 
               
               
                   
               
               
                 269 
                 DKC25i39 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 437.54 
                 1.8 mg 
                 411 
               
               
                   
               
               
                 270 
                 DKC25i40 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 432.61 
                 1.1 mg 
                 254 
               
               
                   
               
               
                 271 
                 DKC25i41 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 338.45 
                 1.0 mg 
                 295 
               
               
                   
               
               
                 272 
                 DKC25i42 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 352.48 
                 2.3 mg 
                 653 
               
               
                   
               
               
                 273 
                 DKC25i43 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 352.48 
                 2.4 mg 
                 681 
               
               
                   
               
               
                 274 
                 DKC25i44 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 340.42 
                 1.4 mg 
                 411 
               
               
                   
               
               
                 275 
                 DKC25i45 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 306.37 
                 1.0 mg 
                 326 
               
               
                   
               
               
                 276 
                 DKC25i46 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 338.41 
                 2.2 mg 
                 650 
               
               
                   
               
               
                 277 
                 DKC25i47 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 409.49 
                 2.0 mg 
                 488 
               
               
                   
               
               
                 278 
                 DKC25i48 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 366.46 
                 1.8 mg 
                 491 
               
               
                   
               
               
                 279 
                 DKC25i49 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 414.51 
                 1.3 mg 
                 314 
               
               
                   
               
               
                 280 
                 DKC25i50 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 394.52 
                 2.0 mg 
                 507 
               
               
                   
               
               
                 281 
                 DKC25i51 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 460.55 
                 1.1 mg 
                 239 
               
               
                   
               
               
                 282 
                 DKC25i52 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 473.57 
                 2.2 mg 
                 465 
               
               
                   
               
               
                 283 
                 DKC25i53 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 449.60 
                 1.5 mg 
                 334 
               
               
                   
               
               
                 284 
                 DKC25i54 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 444.54 
                 2.5 mg 
                 562 
               
               
                   
               
               
                 285 
                 DKC25i55 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 378.47 
                 1.6 mg 
                 423 
               
               
                   
               
               
                 286 
                 DKC25i56 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 402.49 
                 1.1 mg 
                 273 
               
               
                   
               
               
                 287 
                 DKC25i57 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 350.42 
                 1.7 mg 
                 499 
               
               
                   
               
               
                 288 
                 DKC25i58 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 398.50 
                 2.3 mg 
                 577 
               
               
                   
               
               
                 289 
                 DKC25i59 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 467.57 
                 1.4 mg 
                 299 
               
               
                   
               
               
                 290 
                 DKC25i60 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 382.50 
                 2.3 mg 
                 601 
               
               
                   
               
               
                 291 
                 DKC25i61 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 370.45 
                 1.7 mg 
                 459 
               
               
                   
               
               
                 292 
                 DKC25i62 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 438.61 
                 1.3 mg 
                 296 
               
               
                   
               
               
                 293 
                 DKC25i63 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 368.43 
                 1.8 mg 
                 489 
               
               
                   
               
               
                 294 
                 DKC25i64 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 368.48 
                 1.8 mg 
                 488 
               
               
                   
               
               
                 295 
                 DKC25i65 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 396.49 
                 1.2 mg 
                 303 
               
               
                   
               
               
                 296 
                 DKC25i66 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 296.37 
                 1.7 mg 
                 574 
               
               
                   
               
               
                 297 
                 DKC25i67 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 384.48 
                 2.2 mg 
                 572 
               
               
                   
               
               
                 298 
                 DKC25i68 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 364.49 
                 1.7 mg 
                 466 
               
               
                   
               
               
                 299 
                 DKC25i69 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 431.51 
                 1.3 mg 
                 301 
               
               
                   
               
               
                 300 
                 DKC27i70 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 415.50 
                 2.5 mg 
                 602 
               
               
                   
               
               
                 301 
                 DKC25i71 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 419.51 
                 2.2 mg 
                 524 
               
               
                   
               
               
                 302 
                 DKC25i72 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 414.15 
                 2.5 mg 
                 604 
               
               
                   
               
               
                 303 
                 DKC25i73 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 348.45 
                 1.2 mg 
                 344 
               
               
                   
               
               
                 304 
                 DKC25i74 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 338.31 
                 1.8 mg 
                 532 
               
               
                   
               
               
                 305 
                 DKC25i75 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 409.49 
                 1.7 mg 
                 415 
               
               
                   
               
            
           
         
       
     
     Meanwhile, the compound of the present invention may exist in the form of a pharmaceutically acceptable salt. As the salt, an acid addition salt formed by a pharmaceutically acceptable free acid is useful. As used herein, the term “pharmaceutically acceptable salt” refers to any organic or inorganic addition salt of each of the compounds represented by Formulas 1 to 3 whose concentration has effective action because it is relatively non-toxic and harmless to a patient and whose side effects do not degrade the beneficial efficacy of the above compounds. 
     The acid addition salt is prepared by a conventional method, for example, by dissolving the compound in an excess of aqueous acid solution and precipitating the salt using a water-miscible organic solvent such as methanol, ethanol, acetone or acetonitrile. The acid addition salt may also be prepared by heating an equimolar amount of the compound and acid or alcohol (e.g., glycol monomethylether) in water, and then drying the mixture by evaporation or suction-filtering the precipitated salt. 
     As the free acid, an organic acid or inorganic acid may be used. Examples of the inorganic acid include, but are not limited to, hydrochloric acid, phosphoric acid, sulfuric acid, nitric acid, and stannic acid, and examples of the organic acid include, but are not limited to, methanesulfonic acid, p-toluenesulfonic acid, acetic acid, trifluoroacetic acid, maleic acid, succinic acid, oxalic acid, benzoic acid, tartaric acid, fumaric acid, mandelic acid, propionic acid, citric acid, lactic acid, glycolic acid, gluconic acid, galacturonic acid, glutamic acid, glutaric acid, glucuronic acid, aspartic acid, ascorbic acid, carbonic acid, vanillic acid, hydroiodic acid, etc. 
     In addition, a pharmaceutically acceptable metal salt may be prepared using a base. An alkali metal salt or an alkali earth metal salt is obtained, for example, by dissolving a compound in an excess amount of a solution of an alkali metal hydroxide or an alkali earth metal salt hydroxide, filtering undissolved compound salts, and drying the filtrate by evaporation. In particular, preparing a sodium salt, potassium salt or calcium salt as the salt is suitable from the pharmaceutical point of view, but is not limited thereto. Furthermore, the silver salt corresponding thereto may be obtained by reacting an alkali metal or alkali earth metal salt with an appropriate silver salt (e.g., silver nitrate). 
     The pharmaceutically acceptable salt of the compound of the present invention may include a salt of the acidic or basic group that can be present in the compound of Formula 1, unless indicated otherwise. Examples of the pharmaceutically acceptable salt includes sodium, potassium and calcium salts of a hydroxyl group, and other pharmaceutically acceptable salts of an amino group include hydrobromide, sulfate, hydrogen sulfate, phosphate, hydrogen phosphate, dihydrogen phosphate, acetate, succinate, citrate, tartrate, lactate, mandelate, methanesulfonate (mesylate), and p-toluenesulfonate (tosylate) salts. These may be prepared through the salt preparation methods known in the related art. 
     The salt of the compound of Formula 1 of the present invention is a pharmaceutically acceptable salt which exhibits pharmacological activity equivalent to that of the compound of Formula 1. For example, any salt of Formula 1 that delays death caused by metastasis of colorectal cancer cells or treats colorectal cancer by inhibiting the migration and invasion of colorectal cancer cells may be used without limitation. 
     In addition, the compounds represented by Formula 1 according to the present invention include, without limitation, pharmaceutically acceptable salts thereof, as well as possible solvates such as hydrates and all possible stereoisomers that can be prepared therefrom. Solvates and stereoisomers of the compound represented by Formula 1 may be prepared from the compound represented by Formula 1 using methods known in the art. 
     Furthermore, the compound represented by Formula 1 according to the present invention may be prepared in a crystalline form or an amorphous form, and when it is prepared in a crystalline form, it may be optionally hydrated or solvated. The present invention may encompass compounds containing various amounts of water as well as stoichiometric hydrates of the compound represented by Formula 1. Solvates of the compound represented by Formula 1 according to the present invention include both stoichiometric solvates and non-stoichiometric solvates. 
     The compound of Formula 1 according to the present invention may be prepared by the exemplary method to be described later, specific examples of which are shown in the reaction schemes described in the Examples below. 
     In the preparation method according to the present invention, as reactants used in the above reaction schemes, commercially available compounds may be purchased and used as they are, or compounds synthesized by carrying out one or more reactions known in the art or by performing an appropriate modification of the reactions may be used. For example, the reactants may be synthesized by performing one or more reactions in any order in consideration of the presence, type and/or position of a reactive functional group and/or hetero element included in the skeleton structure, without being limited thereto. 
     In another aspect, the present invention provides a composition for inhibiting cancer metastasis and invasion containing the compound of the present invention as an active ingredient. The present invention also provides a composition for treating cancer, preferably colorectal cancer, laryngeal cancer, lung cancer, gastric cancer, hepatocellular cancer, prostate cancer, or breast cancer, containing the compound and pharmaceutically acceptable salt thereof according to the present invention as an active ingredient. Preferably, the composition may be a pharmaceutical composition. 
     In specific examples of the present invention, specific compounds represented by Formula 1 were newly synthesized, and it was confirmed that these compounds had the effect of increasing KAI1 promoter gene expression and inhibiting cancer invasion. 
     As used herein, the term “treatment” or “treating” refers to any action of alleviating or beneficially changing colorectal cancer symptoms by administration of the pharmaceutical composition of the present invention. 
     As described above, the compound of the present invention not only increases the expression of the KAI1 promoter gene, but also exhibits an effect of inhibiting cancer metastasis and invasion. Thus, a pharmaceutical composition containing the compound as an active ingredient may be used for the inhibition of cancer metastasis and invasion and the treatment of colorectal cancer. 
     For example, the composition of the present invention may further contain a pharmaceutically acceptable carrier, diluent or excipient, and may be formulated in various forms such as oral dosage forms, for example, powders, granules, tablets, capsules, suspensions, emulsions, syrups and aerosols, as well as injections such as sterile injectable solutions, according to conventional methods depending on the intended use, and may be administered by various routes, including oral, intravenous, intraperitoneal, subcutaneous, rectal, and topical routes. Examples of a suitable carrier, excipient or diluent that may be contained in the composition include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia gum, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, and mineral oil. In addition, the composition of the present invention may further contain a filler, an anti-agglomeration agent, a lubricant, a wetting agent, a fragrance, an emulsifier, a preservative, and the like. 
     Solid formulations for oral administration include tablets, pills, powders, granules, capsules, and the like, and such solid formulations are prepared by mixing the compound with one or more excipients, for example, starch, calcium carbonate, sucrose, lactose, gelatin, etc. In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. 
     Liquid formulations for oral administration include, for example, suspensions, solutions, emulsions, syrups, etc., and these formulations may contain various excipients, for example, a wetting agent, a sweetener, a fragrance and a preservative, in addition to commonly used simple diluents such as water and liquid paraffin. 
     Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solutions, suspensions, emulsions, lyophilized formulations, and suppositories. Non-aqueous solvents and suspending agents include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate. As the base of the suppository, Witepsol, Macrogol, Tween 61, Cacao butter, laurin fat, glycerogelatin, etc. may be used. Meanwhile, injections may contain conventional additives such as a solubilizer, an isotonic agent, a suspending agent, an emulsifier, a stabilizer, and a preservative. 
     The formulation may be prepared by a conventional mixing, granulation or coating method, and contains the active ingredient in an amount effective for medical treatment, specifically, inhibition of cancer metastasis and invasion, or treatment of colorectal cancer. 
     The pharmaceutical composition of the present invention is administered in a pharmaceutically effective amount. As used herein, the term “pharmaceutically effective amount” refers to an amount sufficient to treat a disease at a reasonable benefit/risk ratio applicable to any medical treatment. The effective dose level of the pharmaceutical composition may be determined depending on factors, including the patient&#39;s health status, the kind and severity of the disease, the activity of the drug, sensitivity to the drug, the mode of administration, the time of administration, the route of administration, excretion rate, and drugs used in combination with the composition, as well as other factors well known in the medical field. The pharmaceutical composition of the present invention may be administered individually or in combination with other therapeutic agents, and may be administered sequentially or simultaneously with conventional therapeutic agents. The pharmaceutical composition may be administered in a single or multiple dosage form. It is important to administer the pharmaceutical composition in the minimum amount that can exhibit the maximum effect without causing side effects, in view of all the above-described factors, and this amount can be easily determined by a person skilled in the art. 
     For example, the dosage of the pharmaceutical composition may increase or decrease depending on the route of administration, the severity of the disease, the patient&#39;s sex, weight and age, etc., and thus the dosage is not intended to limit the scope of the present invention in any sense. 
     A preferred dosage of the compound of the present invention varies depending on the patient&#39;s condition and weight, the severity of the disease, the form of the drug, and the route and duration of administration, but may be appropriately selected by those skilled in the art. 
     In another aspect, the present invention provides a method for inhibiting cancer metastasis and invasion or treating colorectal cancer comprising a step of administering the pharmaceutical composition of the present invention to a subject in need thereof. 
     As used herein, the term “subject” refers to all animals, including humans, monkey, cows, horses, sheep, pigs, chicken, turkeys, quails, cats, dogs, mice, rats, rabbits or guinea pigs that are likely to develop cancer metastasis or invasion, or have cancer metastasis or invasion, or have developed colorectal cancer. When the pharmaceutical composition of the present invention is administered to a subject, it is possible to inhibit cancer metastasis and invasion or to effectively treat colorectal cancer. In addition, since the pharmaceutical composition of the present invention exhibits an effect of inhibiting cancer metastasis and invasion and treating colorectal cancer by increasing the expression of the KAI1 promoter gene, it may exhibit a synergistic effect when administered in combination with an existing therapeutic agent. 
     As used herein, the term “administration” or “administering” means providing a given substance to a patient by any suitable method. The pharmaceutical composition of the present invention may be administered through any general route as long as it can reach the target tissue. The pharmaceutical composition of the present invention may be administered intraperitoneally, intravenously, intramuscularly, subcutaneously, intradermally, orally, topically, intranasally, intrapulmonarily, or intrarectally administration, without being limited thereto. In addition, the composition of the present invention may also be administered using any device capable of delivering the active ingredient to target cells. Preferred administration modes and formulations are intravenous injections, subcutaneous injections, intradermal injections, intramuscular injections, drip injections, and the like. Injections may be prepared using aqueous solvents such as physiological saline and Ringer&#39;s solution, or non-aqueous solvents such as vegetable oil, higher fatty acid esters (e.g., ethyl oleate, etc.), or alcohols (e.g., ethanol, benzyl alcohol, propylene glycol, glycerin, etc.), and may contain pharmaceutical carriers, such as stabilizers (e.g., ascorbic acid, sodium hydrogen sulfite, sodium pyrosulfite, BHA, tocopherol, EDTA, etc.) for preventing deterioration, emulsifiers, buffers for pH adjustment, preservatives (e.g., phenylmercuric nitrate, thimerosal, benzalkonium chloride, phenol, cresol, benzyl alcohol, etc.) for inhibiting microbial growth, etc. 
     Hereinafter, the present invention will be described in more detail with reference to examples. These examples serve to explain the present invention in more detail, and the scope of the present invention is not limited by these examples. 
     Examples 1 to 87. Preparation of Compounds 1 to 87 (DKC1125a01 to 43 and DKC1125b01 to 44) According to the Present Invention 
     Compounds 1 to 87 (DKC1125a01 to 43 and DKC1125b01 to 44) of the present invention were synthesized according to the following Reaction Scheme 1. 
     
       
         
         
             
             
         
       
     
     General Preparation Method for Compounds 1 to 43 (DKC1125a01 to 43) and Compounds 44 to 87 (DKC1125b01 to 44) 
     CH 2 Cl 2  (1 mL) and saturated NaHCO 3  (2 mL) were stirred vigorously and chilled in an ice bath. Each acid chloride (0.29 mmol) shown in Tables 2 and 3 below was added, followed immediately by addition of aminoacetophenone hydrochloride (50 mg, 0.29 mmol). Stirring was continued while warming to room temperature over a period of 1 hour. The organic layer was then separated, and dried with Na 2 SO 4 , and the solvent was evaporated (80 to 90% yield). 
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Acid chlorides used in preparation of Compounds 1 to 43 
               
               
                 (DKC1125a01 to 43) 
               
            
           
           
               
               
               
            
               
                   
                 Compounds 
                 Acid chloride 
               
               
                   
                   
               
               
                   
                 DKC1125a01 
                 4-Chlorobenzoyl chloride 
               
               
                   
                 DKC1125a02 
                 2-Phenoxypropionyl chloride 
               
               
                   
                 DKC1125a03 
                 2-Fluorobenzoyl chloride 
               
               
                   
                 DKC1125a04 
                 4-Fluorobenzoyl chloride 
               
               
                   
                 DKC1125a05 
                 2-Furoyl chloride 
               
               
                   
                 DKC1125a06 
                 2-Chlorobenzoyl Chloride 
               
               
                   
                 DKC1125a07 
                 3-Chlorobenzoyl chloride 
               
               
                   
                 DKC1125a08 
                 Crotonyl chloride 
               
               
                   
                 DKC1125a09 
                 3-Phenylpropionyl chloride 
               
               
                   
                 DKC1125a10 
                 Acryloyl chloride 
               
               
                   
                 DKC1125a11 
                 o-Toluoyl chloride 
               
               
                   
                 DKC1125a12 
                 3-Methoxybenzoyl chloride 
               
               
                   
                 DKC1125a13 
                 m-Toluoyl chloride 
               
               
                   
                 DKC1125a14 
                 Propionyl chloride 
               
               
                   
                 DKC1125a15 
                 Cyclohexanecarbonyl chloride 
               
               
                   
                 DKC1125a16 
                 Cyclopropanecarbonylchloride 
               
               
                   
                 DKC1125a17 
                 Cyclobutanecarbonyl chloride 
               
               
                   
                 DKC1125a18 
                 Thiophene-2-carbonyl chloride 
               
               
                   
                 DKC1125a19 
                 tert-butylacetyl chloride 
               
               
                   
                 DKC1125a20 
                 Pentanoyl chloride 
               
               
                   
                 DKC1125a21 
                 3-nitrobenzene-1-sulfonyl chloride 
               
               
                   
                 DKC1125a22 
                 2,4-Difluorobenzoyl chloride 
               
               
                   
                 DKC1125a23 
                 Methoxyacetyl chloride 
               
               
                   
                 DKC1125a24 
                 Trimethylacetyl chloride 
               
               
                   
                 DKC1125a25 
                 Methanesulfonyl chloride 
               
               
                   
                 DKC1125a26 
                 4-Fluorobenzenesulfonyl chloride 
               
               
                   
                 DKC1125a27 
                 p-Toluenesulfonyl chloride 
               
               
                   
                 DKC1125a28 
                 a-Toluenesulfonyl chloride 
               
               
                   
                 DKC1125a29 
                 3,5-Bis(trifluoromethyl)benzoyl chloride 
               
               
                   
                 DKC1125a30 
                 2-(Trifluoromethyl)benzoyl chloride 
               
               
                   
                 DKC1125a31 
                 3-(Trifluoromethyl)benzoyl chloride 
               
               
                   
                 DKC1125a32 
                 4-(Trifluoromethyl)benzoyl chloride 
               
               
                   
                 DKC1125a33 
                 2-Chloro-4-fluorobenzoyl chloride 
               
               
                   
                 DKC1125a34 
                 3-Nitrobenzoyl chloride 
               
               
                   
                 DKC1125a35 
                 3,4-Difluorobenzoyl chloride 
               
               
                   
                 DKC1125a36 
                 3,5-Dichlorobenzoyl chloride 
               
               
                   
                 DKC1125a37 
                 2,3-Dichlorobenzoyl chloride 
               
               
                   
                 DKC1125a38 
                 4-(Trifluoromethoxy)benzoyl chloride 
               
               
                   
                 DKC1125a39 
                 3-(Trifluoromethoxy)benzoyl chloride 
               
               
                   
                 DKC1125a40 
                 3,5-Dimethylbenzoyl chloride 
               
               
                   
                 DKC1125a41 
                 2-(Trifluoromethoxy)benzoyl chloride 
               
               
                   
                 DKC1125a42 
                 3,5-Dimethoxybenzoyl chloride 
               
               
                   
                 DKC1125a43 
                 4-Biphenylcarbonyl chloride 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 Acid chlorides used in preparation of Compounds 44 to 87 
               
               
                 (DKC1125b01 to 45) 
               
            
           
           
               
               
               
            
               
                   
                 Compounds 
                 Acid chloride 
               
               
                   
                   
               
               
                   
                 DKC1125b01 
                 2-Fluorobenzoyl chloride 
               
               
                   
                 DKC1125b02 
                 4-Fluorobenzoyl chloride 
               
               
                   
                 DKC1125b03 
                 2-Furoyl chloride 
               
               
                   
                 DKC1125b04 
                 3-Chlorobenzoyl chloride 
               
               
                   
                 DKC1125b05 
                 Crotonyl chloride 
               
               
                   
                 DKC1125b06 
                 3-Phenylpropionyl chloride 
               
               
                   
                 DKC1125b07 
                 Acryloyl chloride 
               
               
                   
                 DKC1125b08 
                 o-Toluoyl chloride 
               
               
                   
                 DKC1125b09 
                 3-Methoxybenzoyl chloride 
               
               
                   
                 DKC1125b10 
                 m-Toluoyl chloride 
               
               
                   
                 DKC1125b11 
                 Propionyl chloride 
               
               
                   
                 DKC1125b12 
                 Cyclohexanecarbonyl chloride 
               
               
                   
                 DKC1125b13 
                 Cyclopropanecarbonylchloride 
               
               
                   
                 DKC1125b14 
                 Cyclobutanecarbonyl chloride 
               
               
                   
                 DKC1125b15 
                 Thiophene-2-carbonyl chloride 
               
               
                   
                 DKC1125b16 
                 2-Ethoxybenzoyl chloride 
               
               
                   
                 DKC1125b17 
                 tert-butylacetyl chloride 
               
               
                   
                 DKC1125b18 
                 Pentanoyl chloride 
               
               
                   
                 DKC1125b19 
                 4-Methoxybenzoyl chloride 
               
               
                   
                 DKC1125b20 
                 3-nitrobenzene-1-sulfonyl chloride 
               
               
                   
                 DKC1125b21 
                 2,4-Difluorobenzoyl chloride 
               
               
                   
                 DKC1125b22 
                 Methoxyacetyl chloride 
               
               
                   
                 DKC1125b23 
                 Pivaloyl chloride 
               
               
                   
                 DKC1125b24 
                 4-Fluorobenzenesulfonyl chloride 
               
               
                   
                 DKC1125b25 
                 p-Toluenesulfonyl chloride 
               
               
                   
                 DKC1125b26 
                 4-Chlorobenzenesulfonyl chloride 
               
               
                   
                 DKC1125b27 
                 a-Toluenesulfonyl chloride 
               
               
                   
                 DKC1125b28 
                 4-Methoxybenzenesulfonyl chloride 
               
               
                   
                 DKC1125b29 
                 3,5-Bis(trifluoromethyl)benzoyl chloride 
               
               
                   
                 DKC1125b30 
                 2-(Trifluoromethyl)benzoyl chloride 
               
               
                   
                 DKC1125b31 
                 3-(Trifluoromethyl)benzoyl chloride 
               
               
                   
                 DKC1125b32 
                 4-(Trifluoromethyl)benzoyl chloride 
               
               
                   
                 DKC1125b33 
                 2-Chloro-4-fluorobenzoyl chloride 
               
               
                   
                 DKC1125b34 
                 3-Nitrobenzoyl chloride 
               
               
                   
                 DKC1125b35 
                 3,4-Difluorobenzoyl chloride 
               
               
                   
                 DKC1125b36 
                 3,5-Dichlorobenzoyl chloride 
               
               
                   
                 DKC1125b37 
                 2,3-Dichlorobenzoyl chloride 
               
               
                   
                 DKC1125b38 
                 4-(Trifluoromethoxy)benzoyl chloride 
               
               
                   
                 DKC1125b39 
                 3-(Trifluoromethoxy)benzoyl chloride 
               
               
                   
                 DKC1125b40 
                 3,5-Dimethylbenzoyl chloride 
               
               
                   
                 DKC1125b41 
                 2-(Trifluoromethoxy)benzoyl chloride 
               
               
                   
                 DKC1125b42 
                 3,5-Dimethoxybenzoyl chloride 
               
               
                   
                 DKC1125b43 
                 4-Biphenylcarbonyl chloride 
               
               
                   
                 DKC1125b44 
                 4-Chlorobenzoyl chloride 
               
               
                   
                   
               
            
           
         
       
     
     Confirmation of Preparation of Compounds 1 to 87 (DKC1125a01 to 43 and DKC1125b01 to 44) 
     4-chloro-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a01)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.01 (dd, J=8.5, 1.1 Hz, 2H), 7.87-7.92 (m, 2H), 7.62-7.66 (m, 1H), 7.50-7.53 (m, 2H), 7.34 (s, 1H), 7.10-7.18 (m, 2H), 4.94 (d, J=4.1 Hz, 2H). MS(ESI): m/z 275 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-phenoxypropanamide (DKC1125a02)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.95-7.97 (m, 2H), 7.62 (tt, J=7.5, 1.4 Hz, 1H), 7.55 (s, 1H), 7.47-7.51 (m, 2H), 7.29-7.33 (m, 2H), 6.97-7.03 (m, 3H), 4.67-4.87 (m, 2H), 1.63 (d, J=6.9 Hz, 3H). MS(ESI): m/z 284 (M+1). 
     2-fluoro-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a03)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.13 (td, J=7.7, 1.9 Hz, 1H), 8.04 (dd, J=8.5, 1.1 Hz, 2H), 7.90 (d, J=11.4 Hz, 1H), 7.63-7.66 (m, 1H), 7.48-7.55 (m, 3H), 7.26-7.30 (m, 1H), 7.15-7.21 (m, 1H), 5.01 (dd, J=4.1, 0.9 Hz, 2H). MS(ESI): m/z 258 (M+1). 
     4-fluoro-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a04)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.02-8.04 (m, 2H), 7.88-7.93 (m, 2H), 7.63-7.67 (m, 1H), 7.53 (t, J=7.8 Hz, 2H), 7.29 (s, 1H), 7.11-7.17 (m, 2H), 4.95 (d, J=4.1 Hz, 2H). MS(ESI): m/z 258 (M+1). 
     N-(2-oxo-2-phenylethyl)furan-2-carboxamide (DKC1125a05)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.98-8.00 (m, 2H), 7.58-7.62 (m, 1H), 7.47-7.50 (m, 3H), 7.45-7.31 (1H), 7.13-7.13 (m, 1H), 6.49 (q, J=1.8 Hz, 1H), 4.90 (d, J=4.6 Hz, 2H). MS(ESI): m/z 230 (M+1). 
     2-chloro-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a06)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.01 (dt, J=8.2, 1.6 Hz, 2H), 7.72 (dd, J=7.3, 1.8 Hz, 1H), 7.63 (tt, J=7.4, 1.4 Hz, 1H), 7.48-7.53 (m, 3H), 7.30-7.43 (m, 3H), 4.98 (d, J=4.6 Hz, 2H). MS(ESI): m/z 275 (M+1). 
     3-chloro-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a07)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.00-8.03 (m, 2H), 7.88 (t, J=1.8 Hz, 1H), 7.75 (dd, J=7.8, 0.9 Hz, 1H), 7.64 (t, J=7.3 Hz, 1H), 7.48-7.54 (m, 3H), 7.39 (t, J=8.0 Hz, 2H), 4.94 (d, J=4.1 Hz, 2H). MS(ESI): m/z 275 (M+1). 
     (E)-N-(2-oxo-2-phenylethyl)but-2-enamide (DKC1125a08)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.00 (dt, J=8.4, 1.5 Hz, 2H), 7.63 (tt, J=7.5, 1.4 Hz, 1H), 7.49-7.52 (m, 2H), 6.92 (td, J=7.5, 6.4 Hz, 1H), 6.64 (s, 1H), 5.98 (dt, J=15.2, 1.7 Hz, 1H), 4.84 (d, J=4.6 Hz, 2H), 1.89 (dd, J=6.9, 1.8 Hz, 3H). MS(ESI): m/z 204 (M+1). 
     N-(2-oxo-2-phenylethyl)-3-phenylpropanamide (DKC1125a09)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.95 (dt, J=8.4, 1.5 Hz, 2H), 7.58-7.62 (m, 1H), 7.45-7.49 (m, 2H), 7.16-7.29 (m, 5H), 6.69 (s, 1H), 4.74 (d, J=4.1 Hz, 2H), 3.00 (t, J=7.8 Hz, 2H), 2.62 (dd, J=8.7, 6.9 Hz, 2H). MS (ESI): m/z 268 (M+1). 
     N-(2-oxo-2-phenylethyl) acrylamide (DKC1125a10)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.99-8.01 (m, 2H), 7.63 (tt, J=7.5, 1.4 Hz, 1H), 7.49-7.53 (m, 2H), 6.88 (s, 1H), 6.25-6.39 (m, 2H), 5.71 (dd, J=9.6, 1.8 Hz, 1H), 4.87 (d, J=4.6 Hz, 2H). MS(ESI): m/z 190 (M+1). 
     2-methyl-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a11)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.00 (dt, J=8.2, 1.6 Hz, 2H), 7.62 (tt, J=7.4, 1.4 Hz, 1H), 7.47-7.52 (m, 3H), 7.32 (td, J=7.4, 1.7 Hz, 1H), 7.21 (t, J=7.5 Hz, 2H), 6.97 (s, 1H), 4.92 (d, J=4.6 Hz, 2H), 2.48 (s, 3H). MS(ESI): m/z 254 (M+1). 
     4-methoxy-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a12)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.99-8.01 (m, 2H), 7.62 (tt, J=7.4, 1.4 Hz, 1H), 7.48-7.51 (m, 3H), 7.39-7.45 (m, 3H), 7.34 (t, J=7.8 Hz, 1H), 7.04 (dq, J=8.2, 1.2 Hz, 1H), 4.92 (d, J=4.1 Hz, 2H), 3.84 (t, J=4.6 Hz, 3H). MS(ESI): m/z 270 (M+1). 
     3-methyl-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a13)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.01-8.04 (m, 2H), 7.70 (s, 1H), 7.67 (td, J=4.0, 2.1 Hz, 1H), 7.63 (tt, J=7.4, 1.4 Hz, 1H), 7.49-7.53 (m, 2H), 7.32-7.36 (m, 3H), 4.94 (d, J=4.6 Hz, 2H), 2.38 (d, J=14.2 Hz, 3H). MS (ESI): m/z 254 (M+1). 
     N-(2-oxo-2-phenylethyl)propionamide (DKC1125a14)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.99 (dt, J=8.2, 1.6 Hz, 2H), 7.63 (tt, J=7.4, 1.4 Hz, 1H), 7.49-7.53 (m, 2H), 6.63 (s, 1H), 4.78 (d, J=4.1 Hz, 2H), 2.36 (q, J=7.6 Hz, 2H), 1.22 (t, J=7.5 Hz, 3H). MS(ESI): m/z 192 (M+1). 
     N-(2-oxo-2-phenylethyl)cyclohexanecarboxamide (DKC1125a15)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.97-8.01 (m, 2H), 7.59-7.64 (m, 1H), 7.47-7.51 (m, 2H), 6.68 (s, 1H), 4.58-4.78 (m, 2H), 2.21-2.29 (m, 1H), 1.95 (dd, J=22.2, 12.1 Hz, 2H), 1.76-1.84 (m, 2H), 1.49 (q, J=11.9 Hz, 2H), 1.19-1.35 (m, 4H). MS (ESI): m/z 246 (M+1). 
     N-(2-oxo-2-phenylethyl)cyclopropanecarboxamide (DKC1125a16)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.99 (dt, J=8.2, 1.6 Hz, 2H), 7.63 (tt, J=7.4, 1.4 Hz, 1H), 7.48-7.53 (m, 2H), 6.82 (s, 1H), 4.80 (d, J=4.1 Hz, 2H), 1.57 (tt, J=8.4, 3.8 Hz, 1H), 0.99-1.03 (m, 2H), 0.80 (td, J=7.4, 4.3 Hz, 2H). MS(ESI): m/z 204 (M+1). 
     N-(2-oxo-2-phenylethyl)cyclobutanecarboxamide (DKC1125a17)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.98 (dt, J=8.4, 1.5 Hz, 2H), 7.62 (tt, J=7.3, 1.5 Hz, 1H), 7.48-7.51 (m, 2H), 6.59 (s, 1H), 4.77 (d, J=4.3 Hz, 2H), 3.12-3.21 (m, 1H), 2.29-2.39 (m, 2H), 2.16-2.24 (m, 2H), 1.84-2.05 (m, 2H). MS(ESI): m/z 218 (M+1). 
     N-(2-oxo-2-phenylethyl)thiophene-2-carboxamide (DKC1125a18)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.01-8.04 (m, 2H), 7.62-7.67 (m, 2H), 7.50-7.54 (m, 3H), 7.19 (s, 1H), 7.11 (dd, J=4.8, 3.9 Hz, 1H), 4.95 (d, J=4.6 Hz, 2H). MS (ESI): m/z 246 (M+1). 
     3,3-dimethyl-N-(2-oxo-2-phenylethyl) butanamide (DKC1125a19)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.97-8.00 (m, 2H), 7.60-7.64 (m, 1H), 7.47-7.52 (m, 2H), 6.62 (d, J=13.7 Hz, 1H), 4.79 (dd, J=4.3, 1.1 Hz, 2H), 2.21 (S, 2H), 1.07 (d, J=1.4 Hz, 9H). MS(ESI): m/z 234 (M+1). 
     N-(2-oxo-2-phenylethyl)pentanamide (DKC1125a20)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.99 (dt, J=8.4, 1.5 Hz, 2H), 7.60-7.64 (m, 1H), 7.48-7.52 (m, 2H), 6.68 (s, 1H), 4.78 (d, J=4.1 Hz, 2H), 2.32 (t, J=7.5 Hz, 2H), 1.64-1.71 (m, 2H), 1.34-1.41 (m, 2H), 0.93 (td, J=7.3, 2.3 Hz, 3H). MS (ESI): m/z 220 (M+1). 
     3-nitro-N-(2-oxo-2-phenylethyl)benzenesulfonamide (DKC1125a21)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.76 (t, J=2.1 Hz, 1H), 8.40-8.43 (m, 1H), 8.23-8.25 (m, 1H), 7.85-7.87 (m, 2H), 7.74 (t, J=8.2 Hz, 1H), 7.63 (t, J=7.5 Hz, 1H), 7.49 (t, J=7.8 Hz, 2H), 5.94 (s, 1H), 4.57 (d, J=4.6 Hz, 2H). MS(ESI): m/z 321 (M+1). 
     2,4-difluoro-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a22)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.15 (td, J=8.8, 6.6 Hz, 1H), 8.03 (dd, J=8.5, 1.1 Hz, 2H), 7.83 (d, J=10.5 Hz, 1H), 7.64 (t, J=7.3 Hz, 1H), 7.52 (t, J=7.8 Hz, 2H), 6.89-7.03 (m, 2H), 4.99 (d, J=4.1 Hz, 2H). MS(ESI): m/z 276 (M+1). 
     2-methoxy-N-(2-oxo-2-phenylethyl) acetamide (DKC1125a23)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.97-8.00 (m, 2H), 7.60-7.64 (m, 1H), 7.48-7.55 (m, 3H), 4.80 (d, J=5.0 Hz, 2H), 3.99 (s, 2H), 3.48 (s, 3H). MS(ESI): m/z 208 (M+1). 
     N-(2-oxo-2-phenylethyl)pivalamide (DKC1125a24)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.97-8.07 (m, 2H), 7.62 (t, J=7.5 Hz, 1H), 7.50 (t, J=7.8 Hz, 2H), 6.85 (s, 1H), 4.74 (d, J=4.1 Hz, 2H), 1.12-1.34 (m, 9H). MS(ESI): m/z 220 (M+1). 
     N-(2-oxo-2-phenylethyl)methanesulfonamide (DKC1125a25)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.94-7.97 (m, 2H), 7.64 (tt, J=7.4, 1.4 Hz, 1H), 7.49-7.53 (m, 2H), 5.60 (t, J=4.6 Hz, 1H), 4.69 (d, J=5.0 Hz, 2H), 3.03 (s, 3H). MS(ESI): m/z 214 (M+1). 
     4-fluoro-N-(2-oxo-2-phenylethyl)benzenesulfonamide (DKC1125a26)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.93 (tt, J=7.2, 2.4 Hz, 2H), 7.84-7.87 (m, 2H), 7.60-7.64 (m, 1H), 7.46-7.50 (m, 2H), 7.14-7.20 (m, 2H), 5.80 (t, J=4.6 Hz, 1H), 4.49 (d, J=4.6 Hz, 2H). MS(ESI): m/z 294 (M+1). 
     4-methyl-N-(2-oxo-2-phenylethyl)benzenesulfonamide (DKC1125a27)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.85 (dd, J=8.5, 1.1 Hz, 2H), 7.79 (d, J=8.7 Hz, 2H), 7.58-7.62 (m, 1H), 7.46 (t, J=7.8 Hz, 2H), 7.28 (d, J=8.2 Hz, 2H), 5.74 (t, J=4.3 Hz, 1H), 4.47 (d, J=4.6 Hz, 2H), 2.39 (s, 3H). MS (ESI): m/z 290 (M+1). 
     N-(2-oxo-2-phenylethyl)-1-phenylmethanesulfonamide (DKC1125a28)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.78 (d, J=7.3 Hz, 2H), 7.60 (t, J=7.3 Hz, 1H), 7.42-7.47 (m, 4H), 7.29-7.34 (m, 3H), 5.55 (t, J=4.3 Hz, 1H), 4.35 (s, 2H), 4.31 (d, J=4.6 Hz, 2H). MS(ESI): m/z 290 (M+1). 
     N-(2-oxo-2-phenylethyl)-3,5-bis(trifluoromethyl)benzamide (DKC1125a29)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.34 (s, 2H), 8.03-8.06 (m, 3H), 7.66-7.70 (m, 1H), 7.55 (t, J=7.5 Hz, 2H), 7.49 (s, 1H), 5.00 (d, J=4.6 Hz, 2H). MS(ESI): m/z 376 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-(trifluoromethyl)benzamide (DKC1125a30)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.97-7.99 (m, 2H), 7.48-7.71 (m, 7H), 7.07 (s, 1H), 4.95 (d, J=4.1 Hz, 2H). MS (ESI): m/z 308 (M+1). 
     N-(2-oxo-2-phenylethyl)-3-(trifluoromethyl)benzamide (DKC1125a31)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.17 (s, 1H), 8.02-8.07 (m, 3H), 7.79 (d, J=8.2 Hz, 1H), 7.58-7.68 (m, 2H), 7.51-7.55 (m, 2H), 7.43 (s, 1H), 4.98 (d, J=4.6 Hz, 2H). MS(ESI): m/z 308 (M+1). 
     N-(2-oxo-2-phenylethyl)-4-(trifluoromethyl)benzamide (DKC1125a32)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.00-8.06 (m, 4H), 7.75 (d, J=8.2 Hz, 2H), 7.65-7.69 (m, 1H), 7.55 (t, J=7.8 Hz, 2H), 7.37 (s, 1H), 4.98 (d, J=4.1 Hz, 2H). MS (ESI): m/z 308 (M+1). 
     2-chloro-4-fluoro-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a33)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.99-8.01 (m, 2H), 7.77 (dd, J=8.7, 5.9 Hz, 1H), 7.62-7.66 (m, 1H), 7.49-7.55 (m, 3H), 7.15 (dd, J=8.5, 2.5 Hz, 1H), 7.04 (td, J=8.2, 2.7 Hz, 1H), 4.97 (d, J=4.6 Hz, 2H). MS(ESI): m/z 293 (M+1). 
     3-nitro-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a34)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.73 (t, J=2.1 Hz, 1H), 8.37 (dd, J=7.8, 1.8 Hz, 1H), 8.23 (dt, J=7.9, 1.4 Hz, 1H), 8.02-8.04 (m, 2H), 7.64-7.69 (m, 2H), 7.51-7.55 (m, 3H), 5.00 (d, J=4.1 Hz, 2H). MS(ESI): m/z 285 (M+1). 
     3,4-difluoro-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a35)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.02-8.04 (m, 2H), 7.73-7.78 (m, 1H), 7.62-7.68 (m, 2H), 7.52-7.56 (m, 2H), 7.23-7.29 (m, 2H), 4.94-4.95 (m, 2H). MS(ESI): m/z 276 (M+1). 
     3,5-dichloro-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a36)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.01-8.03 (m, 2H), 7.75 (d, J=1.8 Hz, 2H), 7.66 (tt, J=7.4, 1.4 Hz, 1H), 7.50-7.55 (m, 3H), 7.33 (s, 1H), 4.94 (d, J=4.1 Hz, 2H) MS(ESI): m/z 309 (M+1). 
     2,3-dichloro-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a37)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.99-8.01 (m, 2H), 7.63-7.67 (m, 1H), 7.51-7.55 (m, 4H), 7.27 (t, J=8.0 Hz, 2H), 4.98 (d, J=4.1 Hz, 2H). MS(ESI): m/z 309 (M+1). 
     N-(2-oxo-2-phenylethyl)-4-(trifluoromethoxy)benzamide (DKC1125a38) (DKC1125a38)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.01-8.03 (m, 2H), 7.93 (dt, J=9.3, 2.3 Hz, 2H), 7.64 (t, J=7.5 Hz, 1H), 7.52 (t, J=7.8 Hz, 2H), 7.39 (s, 1H), 7.28 (d, J=8.2 Hz, 2H), 4.95 (d, J=4.1 Hz, 2H). MS(ESI): m/z 324 (M+1). 
     N-(2-oxo-2-phenylethyl)-3-(trifluoromethoxy)benzamide (DKC1125a39)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.01 (dd, J=8.5, 1.1 Hz, 2H), 7.77-7.81 (m, 2H), 7.61-7.66 (m, 1H), 7.46-7.53 (m, 4H), 7.37 (dt, J=8.4, 1.1 Hz, 1H), 4.95 (d, J=4.6 Hz, 2H). MS(ESI): m/z 324 (M+1). 
     3,5=dimethyl-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a40)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.00-8.02 (m, 2H), 7.60-7.64 (m, 1H), 7.50 (t, J=7.5 Hz, 4H), 7.34 (s, 1H), 7.13 (s, 1H), 4.93 (d, J=4.1 Hz, 2H), 2.31-2.36 (m, 6H) MS(ESI): m/z 268 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-(trifluoromethoxy)benzamide (DKC1125a41)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.03 (tt, J=5.3, 1.9 Hz, 3H), 7.80 (s, 1H), 7.63 (tt, J=7.4, 1.4 Hz, 1H), 7.49-7.55 (m, 3H), 7.40 (td, J=7.5, 1.1 Hz, 1H), 7.34 (dt, J=8.2, 1.4 Hz, 1H), 4.99 (d, J=4.6 Hz, 2H). MS(ESI): m/z 324 (M+1). 
     3,5-dimethoxy-N-(2-oxo-2-phenylethyl)benzamide (DKC1125a42)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.99-8.02 (m, 2H), 7.63 (tt, J=7.4, 1.4 Hz, 1H), 7.48-7.52 (m, 2H), 7.36 (d, J=3.7 Hz, 1H), 7.00 (d, J=2.3 Hz, 2H), 6.59 (t, J=2.3 Hz, 1H), 4.92 (d, J=4.1 Hz, 2H), 3.80 (d, J=10.1 Hz, 6H). MS(ESI): m/z 300 (M+1). 
     N-(2-oxo-2-phenylethyl)-[1,1′-biphenyl]-4-carboxamide (DKC1125a43)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.04-8.06 (m, 2H), 7.97 (dt, J=8.4, 1.9 Hz, 2H), 7.61-7.71 (m, 5H), 7.53 (t, J=7.8 Hz, 2H), 7.45-7.49 (m, 2H), 7.37-7.41 (m, 2H), 4.99 (d, J=4.1 Hz, 2H). MS(ESI): m/z 316 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-2-fluorobenzamide (DKC1125b01)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.11 (tt, J=7.9, 2.4 Hz, 1H), 7.97 (dt, J=9.0, 2.1 Hz, 2H), 7.84-7.87 (m, 1H), 7.47-7.53 (m, 3H), 7.25-7.29 (m, 1H), 7.10-7.19 (m, 1H), 4.97 (dd, J=4.3, 1.1 Hz, 2H). MS(ESI): m/z 293 (M+1) 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-4-fluorobenzamide (DKC1125b02)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.88-7.97 (m, 4H), 7.50 (dd, J=8.0, 1.6 Hz, 2H), 7.26 (s, 1H), 7.12-7.16 (m, 2H), 4.91 (d, J=2.7 Hz, 2H). MS(ESI): m/z 293 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)furan-2-carboxamide (DKC1125b03)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.96-7.98 (m, 2H), 7.48-7.51 (m, 2H), 7.28-7.39 (m, 1H), 7.16 (d, J=1.8 Hz, 1H), 6.52 (s, 1H), 4.90 (t, J=2.1 Hz, 2H). MS(ESI): m/z 265 (M+1). 
     3-chloro-N-(2-(4-chlorophenyl)-2-oxoethyl)benzamide (DKC1125b04)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.94-7.96 (m, 2H), 7.86 (t, J=1.6 Hz, 1H), 7.73 (dd, J=7.8, 0.9 Hz, 1H), 7.47-7.50 (m, 3H), 7.35-7.41 (m, 2H), 4.91 (d, J=4.1 Hz, 2H). MS(ESI): m/z 309 (M+1). 
     (E)-N-(2-(4-chlorophenyl)-2-oxoethyl)but-2-enamide (DKC1125b05)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.93-7.96 (m, 2H), 7.47-7.50 (m, 2H), 6.92 (q, J=7.3 Hz, 1H), 6.59 (s, 1H), 5.97 (dd, J=15.1, 1.8 Hz, 1H), 4.81 (d, J=4.6 Hz, 2H), 1.89 (dd, J=6.9, 1.8 Hz, 3H). MS(ESI): m/z 239 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-3-phenylpropanamide (DKC1125b06)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.89 (dt, J=9.0, 2.3 Hz, 2H), 7.45 (dt, J=8.8, 2.3 Hz, 2H), 7.25-7.30 (m, 2H), 7.17-7.22 (m, 3H), 6.62 (s, 1H), 4.70 (d, J=4.1 Hz, 2H), 3.00 (t, J=7.9 Hz, 2H), 2.62 (dd, J=8.7, 6.9 Hz, 2H). MS(ESI): m/z 303 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)acrylamide (DKC1125b07)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.93-7.96 (m, 2H), 7.48-7.51 (m, 2H), 6.78 (s, 1H), 6.23-6.39 (m, 2H), 5.73 (dd, J=10.1, 1.8 Hz, 1H), 4.83 (d, J=4.6 Hz, 2H). MS (ESI): m/z 225 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-2-methylbenzamide (DKC1125b08)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.95 (dt, J=9.0, 2.1 Hz, 2H), 7.46-7.51 (m, 3H), 7.32-7.36 (m, 1H), 7.21-7.27 (m, 2H), 6.90 (s, 1H), 4.90 (d, J=4.6 Hz, 2H), 2.47 (d, J=4.6 Hz, 3H). MS(ESI): m/z 289 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-4-methoxybenzamide (DKC1125b09)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.94 (dt, J=9.0, 2.1 Hz, 2H), 7.48 (dt, J=8.7, 1.9 Hz, 2H), 7.40-7.43 (m, 2H), 7.31-7.37 (m, 2H), 7.04-7.07 (m, 1H), 4.90 (d, J=4.1 Hz, 2H), 3.84 (s, 3H). MS(ESI): m/z 305 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-3-methylbenzamide (DKC1125b10)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.96 (dt, J=9.0, 2.1 Hz, 2H), 7.64-7.69 (m, 2H), 7.48 (dt, J=9.0, 2.1 Hz, 2H), 7.30-7.34 (m, 3H), 4.91 (d, J=4.3 Hz, 2H), 2.39 (d, J=10.1 Hz, 3H). MS(ESI): m/z 289 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl) propionamide (DKC1125b11)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.92-7.95 (m, 2H), 7.47-7.50 (m, 2H), 6.60 (s, 1H), 4.75 (d, J=4.6 Hz, 2H), 2.35 (q, J=7.6 Hz, 2H), 1.22 (t, J=7.5 Hz, 3H). MS (ESI): m/z 227 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)cyclohexanecarboxamide (DKC1125b12)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.92 (dt, J=8.8, 2.2 Hz, 2H), 7.48 (dt, J=9.0, 2.1 Hz, 2H), 6.62 (s, 1H), 4.73 (d, J=4.6 Hz, 2H), 2.24 (tt, J=11.7, 3.6 Hz, 1H), 1.92 (dd, J=13.5, 2.1 Hz, 2H), 1.80-1.84 (m, 2H), 1.67-1.71 (m, 1H), 1.49 (qd, J=12.2, 2.9 Hz, 2H), 1.21-1.36 (m, 3H). MS(ESI): m/z 281 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)cyclopropanecarboxamide (DKC1125b13)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.92-7.95 (m, 2H), 7.48-7.50 (m, 2H), 6.70 (s, 1H), 4.76 (d, J=4.6 Hz, 2H), 1.51-1.56 (m, 1H), 1.01 (dt, J=8.2, 3.5 Hz, 2H), 0.81 (td, J=7.4, 4.3 Hz, 2H). MS (ESI): m/z 239 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)cyclobutanecarboxamide (DKC1125b14)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.91-7.94 (m, 2H), 7.46-7.49 (m, 2H), 6.50 (s, 1H), 4.74 (d, J=4.1 Hz, 2H), 3.11-3.20 (m, 1H), 1.85-2.38 (m, 6H). MS (ESI): m/z 253 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)thiophene-2-carboxamide (DKC1125b15)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.94-7.97 (m, 2H), 7.64 (dd, J=3.7, 0.9 Hz, 1H), 7.47-7.52 (m, 3H), 7.09-7.19 (m, 2H), 4.90 (d, J=4.1 Hz, 2H). MS(ESI): m/z 281 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-2-(methoxymethyl)benzamide (DKC1125b16)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.19 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 7.97 (dt, J=9.0, 2.1 Hz, 2H), 7.42-7.49 (m, 3H), 6.98-7.08 (m, 2H), 4.97 (d, J=4.1 Hz, 2H), 4.25 (q, J=7.0 Hz, 2H), 1.70 (t, J=7.1 Hz, 3H). MS(ESI): m/z 319 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-3,3-dimethylbutanamide (DKC1125b17)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.93 (dt, J=9.0, 2.1 Hz, 2H), 7.48 (dt, J=9.0, 2.3 Hz, 2H), 6.52 (s, 1H), 4.75 (d, J=4.6 Hz, 2H), 2.20 (s, 2H), 1.07 (d, J=2.3 Hz, 9H). MS(ESI): m/z 269 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)pentanamide (DKC1125b18)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.93 (dt, J=9.0, 2.3 Hz, 2H), 7.47-7.50 (m, 2H), 6.63 (s, 1H), 4.75 (d, J=4.6 Hz, 2H), 2.32 (t, J=7.5 Hz, 2H), 1.62-1.71 (m, 2H), 1.33-1.43 (m, 2H), 0.93 (td, J=7.2, 4.3 Hz, 3H). MS(ESI): m/z 255 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-4-methoxybenzamide (DKC1125b19)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.96-7.99 (m, 2H), 7.84-7.87 (m, 2H), 7.49-7.51 (m, 2H), 7.19 (s, 1H), 6.94-6.97 (m, 2H), 4.92 (d, J=4.1 Hz, 2H), 3.86 (d, J=4.1 Hz, 3H). MS(ESI): m/z 305 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-3-nitrobenzenesulfonamide (DKC1125b20)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.75 (t, J=1.8 Hz, 1H), 8.42-8.44 (m, 1H), 8.23 (d, J=7.8 Hz, 1H), 7.81 (d, J=8.2 Hz, 2H), 7.75 (t, J=8.0 Hz, 1H), 7.47 (d, J=8.7 Hz, 2H), 5.81 (s, 1H), 4.53 (d, J=4.1 Hz, 2H). MS(ESI): m/z 356 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-2,4ifluorobenzamide (DKC1125b21)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.11-8.18 (m, 1H), 7.97 (dt, J=9.0, 2.3 Hz, 2H), 7.77-7.80 (m, 1H), 7.50 (dt, J=9.0, 2.3 Hz, 2H), 6.98-7.03 (m, 1H), 6.88-6.95 (m, 1H), 4.96 (dd, J=4.1, 0.9 Hz, 2H). MS(ESI): m/z 311 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-2-methoxyacetamide (DKC1125b22)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.93 (dt, J=8.8, 2.2 Hz, 2H), 7.49 (dt, J=9.0, 2.1 Hz, 3H), 4.77 (d, J=4.6 Hz, 2H), 3.99 (s, 2H), 3.49 (s, 3H). MS(ESI): m/z 243 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)pivalamide (DKC1125b23)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.92-7.95 (m, 2H), 7.47-7.50 (m, 2H), 6.79 (s, 1H), 4.71 (d, J=4.1 Hz, 2H), 1.27 (d, J=5.5 Hz, 9H). MS(ESI): m/z 255 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-4-fluorobenzenesulfonamide (DKC1125b24)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.92 (tt, J=7.3, 2.3 Hz, 2H), 7.80 (dt, J=9.0, 2.1 Hz, 2H), 7.45 (dt, J=8.8, 2.3 Hz, 2H), 7.18 (tt, J=8.8, 2.7 Hz, 2H), 5.73 (t, J=4.3 Hz, 1H), 4.46 (d, J=4.6 Hz, 2H). MS(ESI): m/z 329 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-4-methylbenzenesulfonamide (DKC1125b25)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.77-7.81 (m, 4H), 7.44 (dd, J=6.6, 1.6 Hz, 2H), 7.29 (d, J=8.2 Hz, 2H), 5.66 (s, 1H), 4.43 (d, J=4.6 Hz, 2H), 2.40 (s, 3H). MS(ESI): m/z 325 (M+1). 
     4-chloro-N-(2-(4-chlorophenyl)-2-oxoethyl)benzenesulfonamide (DKC1125b26)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.99 (dt, J=9.3, 2.3 Hz, 1H), 7.78-7.85 (m, 3H), 7.61 (dt, J=9.0, 2.3 Hz, 1H), 7.44-7.49 (m, 3H), 5.71 (t, J=4.3 Hz, 1H), 4.45 (d, J=4.6 Hz, 2H). MS(ESI): m/z 345 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-1-phenylmethanesulfonamide (DKC1125b27)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.72 (dt, J=9.0, 2.1 Hz, 2H), 7.41-7.46 (m, 4H), 7.32-7.36 (m, 3H), 5.36 (t, J=4.3 Hz, 1H), 4.35 (s, 2H), 4.24 (d, J=4.6 Hz, 2H). MS(ESI): m/z 325 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-4-methoxybenzenesulfonamide (DKC1125b28)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.78-7.84 (m, 4H), 7.45 (dt, J=9.0, 2.3 Hz, 2H), 6.96 (dt, J=9.6, 2.5 Hz, 2H), 4.42 (d, J=4.6 Hz, 2H), 3.84 (s, 3H). MS(ESI): m/z 341 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-3,5-bis(trifluoromethyl)benzamide (DKC1125b29)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.33 (s, 2H), 8.04 (s, 1H), 7.98 (dd, J=6.9, 1.8 Hz, 2H), 7.53 (dd, J=6.9, 1.8 Hz, 2H), 7.46 (s, 1H), 4.97 (d, J=4.1 Hz, 2H). MS(ESI): m/z 411 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-2-(trifluoromethyl)benzamide (DKC1125b30)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.94 (d, J=8.7 Hz, 2H), 7.72 (d, J=7.3 Hz, 1H), 7.54-7.63 (m, 3H), 7.50 (d, J=8.7 Hz, 2H), 6.98 (s, 1H), 4.93 (d, J=4.6 Hz, 2H). MS(ESI): m/z 343 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-3-(trifluoromethyl)benzamide (DKC1125b31)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.15 (s, 1H), 8.05 (d, J=7.8 Hz, 1H), 7.96 (dt, J=9.0, 2.1 Hz, 2H), 7.76-7.79 (m, 1H), 7.59 (t, J=7.8 Hz, 1H), 7.48-7.51 (m, 2H), 4.94 (d, J=4.6 Hz, 2H). MS (ESI): m/z 343 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-4-(trifluoromethyl)benzamide (DKC1125b32)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.96-8.00 (m, 4H), 7.74 (d, J=8.2 Hz, 2H), 7.52 (dt, J=8.8, 2.2 Hz, 2H), 7.36 (s, 1H), 4.94 (d, J=4.1 Hz, 2H). MS(ESI): m/z 343 (M+1). 
     2-chloro-N-(2-(4-chlorophenyl)-2-oxoethyl)-4-fluorobenzamide (DKC1125b33)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.96 (dt, J=9.0, 2.1 Hz, 2H), 7.80 (dd, J=8.7, 5.9 Hz, 1H), 7.51 (dt, J=9.0, 2.3 Hz, 2H), 7.46 (s, 1H), 7.19 (dd, J=8.5, 2.5 Hz, 1H), 7.05-7.10 (m, 1H), 4.95 (d, J=4.1 Hz, 2H). MS(ESI): m/z 327 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-3-nitrobenzamide (DKC1125b34)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.74 (t, J=1.8 Hz, 1H), 8.41 (dq, J=8.2, 1.1 Hz, 1H), 8.23 (dd, J=7.8, 0.9 Hz, 1H), 7.98-8.01 (m, 2H), 7.70 (t, J=8.0 Hz, 1H), 7.52-7.55 (m, 2H), 7.38 (s, 1H), 4.97 (d, J=4.1 Hz, 2H). MS(ESI): m/z 320 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-3,4ifluorobenzamide (DKC1125b35)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.97 (dt, J=9.0, 2.3 Hz, 2H), 7.75 (ddd, J=10.6, 7.4, 2.2 Hz, 1H), 7.61-7.65 (m, 1H), 7.51 (dt, J=9.0, 2.1 Hz, 2H), 7.23-7.29 (m, 2H), 4.91 (d, J=4.1 Hz, 2H). MS(ESI): m/z 311 (M+1). 
     3,5-dichloro-N-(2-(4-chlorophenyl)-2-oxoethyl)benzamide (DKC1125b36)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.98 (dt, J=9.0, 2.3 Hz, 2H), 7.74 (d, J=1.8 Hz, 2H), 7.53 (td, J=4.5, 2.1 Hz, 3H), 7.21 (s, 1H), 4.91 (d, J=4.1 Hz, 2H). MS(ESI): m/z 344 (M+1). 
     2,3-dichloro-N-(2-(4-chlorophenyl)-2-oxoethyl)benzamide (DKC1125b37)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.95 (d, J=7.8 Hz, 2H), 7.49-7.55 (m, 4H), 7.28 (t, J=7.5 Hz, 2H), 4.94 (d, J=4.1 Hz, 2H). MS(ESI): m/z 344 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-4-(trifluoromethoxy)benzamide (DKC1125b38)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.97 (dt, J=9.0, 2.1 Hz, 2H), 7.93 (dt, J=9.1, 2.4 Hz, 2H), 7.50 (dt, J=9.1, 2.0 Hz, 2H), 7.26-7.32 (m, 3H), 4.92 (d, J=4.1 Hz, 2H). MS(ESI): m/z 359 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-3-(trifluoromethoxy)benzamide (DKC1125b39)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.96 (dt, J=8.8, 2.2 Hz, 2H), 7.77-7.79 (m, 1H), 7.75 (s, 1H), 7.48-7.52 (m, 3H), 7.36-7.40 (m, 2H), 4.92 (d, J=4.1 Hz, 2H). MS(ESI): m/z 359 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-3,5-dimethylbenzamide (DKC1125b40)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.98 (dt, J=9.0, 2.1 Hz, 2H), 7.50 (dt, J=9.0, 2.1 Hz, 2H), 7.47 (s, 2H), 7.23 (s, 1H), 7.16 (s, 1H), 4.92 (d, J=4.1 Hz, 2H), 2.37 (s, 6H). MS(ESI): m/z 303 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-2-(trifluoromethoxy)benzamide (DKC1125b41)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.04 (dd, J=7.8, 1.4 Hz, 1H), 7.97 (dt, J=9.1, 2.1 Hz, 2H), 7.76 (s, 1H), 7.48-7.56 (m, 3H), 7.41 (td, J=7.5, 1.2 Hz, 1H), 7.35 (dd, J=8.2, 1.4 Hz, 1H), 4.96 (d, J=4.6 Hz, 2H). MS(ESI): m/z 359 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-3,5imethoxybenzamide (DKC1125b42)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.95 (dt, J=9.0, 2.1 Hz, 2H), 7.48 (dt, J=9.0, 2.3 Hz, 2H), 7.31 (t, J=3.9 Hz, 1H), 6.99 (d, J=2.3 Hz, 2H), 6.59 (t, J=2.3 Hz, 1H), 4.89 (d, J=4.6 Hz, 2H), 3.82 (s, 6H). MS(ESI): m/z 335 (M+1). 
     N-(2-(4-chlorophenyl)-2-oxoethyl)-[1,1′-biphenyl]-4-carboxamide (DKC1125b43)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.95-8.01 (m, 4H), 7.70 (d, J=8.2 Hz, 2H), 7.62-7.65 (m, 2H), 7.46-7.54 (m, 4H), 7.40-7.42 (m, 1H), 7.31 (s, 1H), 4.96 (d, J=4.1 Hz, 2H). MS(ESI): m/z 351 (M+1). 
     4-chloro-N-(2-(4-chlorophenyl)-2-oxoethyl)benzamide (DKC1125b44)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.90 (dd, J=6.6, 2.1 Hz, 2H), 7.75 (dd, J=8.7, 2.3 Hz, 2H), 7.36-7.45 (m, 4H), 7.23 (s, 1H), 4.85 (d, J=4.6 Hz, 2H). MS(ESI): m/z 309 (M+1). 
     Examples 88 to 121. Preparation of Compounds 88 to 122 (DKC1125c01 to 34) According to the Present Invention 
     Compounds 88 to 122 (DKC1125c01 to 34) of the present invention were synthesized according to the following Reaction Scheme 2. 
     
       
         
         
             
             
         
       
     
     Synthesis of 2-bromo-1-(4-(dimethylamino)phenyl)ethan-1-one (1) 
     To a solution of 1-(4-(dimethylamino)phenyl)ethan-1-one (5 g, 30.63 mmol) in HBr (100 mL) at 0° C. was added Br 2  (4.9 g, 30.63 mmol) dropwise over 1 hour. After the reaction was complete, the product was extracted twice with CH 2 Cl 2  and washed with saturated NaHCO 3 . The organic layer was dried with MgSO 4 , and the solvent was evaporated. The resulting crude product was purified by column chromatography to obtain compound (1) (7.09 g, 95%) of reaction scheme 2. 
       1 H NMR (400 MHz, CDCl 3 ) δ 7.89 (d, J=9.0 Hz, 2H), 6.66 (d, J=9.0 Hz, 2H), 4.36 (s, 2H), 3.08 (s, 6H). 
     Synthesis of 2-amino-1-(4-(dimethylamino)phenyl)ethan-1-one hydrochloride (2) 
     2-bromo-1-(4-(dimethylamino)phenyl) ethan-1-one (1.6 g, 24.78 mmol) was dissolved in 20 mL of dry potassium phthalimide (5.05 g, 27.26 mmol) solution, and held at 75° C. for 18 hrs. The suspension was quenched in 90 mL of water with stirring, which was maintained for 40 min, and the product was collected, washed with 50 mL of water, and recrystallized from 50 mL of acetonitrile at 0° C. overnight. (4.58 g, 60%). The solid was dissolved in a solution (90 mL) of 1:2 of concentrated HCl and EtOH. The reaction was boiled under reflux for 2 hrs. The precipitate was filtered out and washed with water and then EtOH (2.61 g, 70%). 
       1 H NMR (400 MHz, (CD 3 ) 2 SO) δ 7.91 (d, J=9.5 Hz, 2H) 6.66 (d, J=9.5 Hz, 2H), 5.06 (s, 2H), 1.22 (s, 6H). 
     General Preparation Method for Compounds 88 to 121 (DKC1125c01 to 34) 
     CH 2 Cl 2  (1 mL) and saturated NaHCO 3  (2 mL) were stirred vigorously and chilled in an ice bath. Each acid chloride (0.29 mmol) described in Table 4 below was added, followed immediately by addition of 2-amino-1-(4-(dimethylamino)phenyl)ethan-1-one dihydrochloride (2, 50 mg, 0.29 mmol). Stirring was continued while warming to room temperature over period of 1 hour. The organic layer was then separated, and dried with Na 2 SO 4 , and the solvent was evaporated. The residue was purified by column chromatography (yield: 70 to 80%). 
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 Acid chlorides for preparation of compounds 88 to 121 
               
               
                 (DKC1125c01 to 34) 
               
            
           
           
               
               
               
            
               
                   
                 Compounds 
                 Acid chloride 
               
               
                   
                   
               
               
                   
                 DKC1125c01 
                 4-Chlorobenzoyl chloride 
               
               
                   
                 DKC1125c02 
                 2-Phenoxypropionyl chloride 
               
               
                   
                 DKC1125c03 
                 2-Fluorobenzoyl chloride 
               
               
                   
                 DKC1125c04 
                 4-Fluorobenzoyl chloride 
               
               
                   
                 DKC1125c05 
                 2-Furoyl chloride 
               
               
                   
                 DKC1125c06 
                 2-Chlorobenzoyl Chloride 
               
               
                   
                 DKC1125c07 
                 3-Chlorobenzoyl chloride 
               
               
                   
                 DKC1125c08 
                 Acryloyl chloride 
               
               
                   
                 DKC1125c09 
                 o-Toluoyl chloride 
               
               
                   
                 DKC1125c10 
                 3-Methoxybenzoyl chloride 
               
               
                   
                 DKC1125c11 
                 m-Toluoyl chloride 
               
               
                   
                 DKC1125c12 
                 Propionyl chloride 
               
               
                   
                 DKC1125c13 
                 Cyclopropanecarbonylchloride 
               
               
                   
                 DKC1125c14 
                 Thiophene-2-carbonyl chloride 
               
               
                   
                 DKC1125c15 
                 tert-butylacetyl chloride 
               
               
                   
                 DKC1125c16 
                 Pentanoyl chloride 
               
               
                   
                 DKC1125c17 
                 4-Methoxybenzoyl chloride 
               
               
                   
                 DKC1125c18 
                 2,4-Difluorobenzoyl chloride 
               
               
                   
                 DKC1125c19 
                 Methoxyacetyl chloride 
               
               
                   
                 DKC1125c20 
                 4-Fluorobenzenesulfonyl chloride 
               
               
                   
                 DKC1125c21 
                 4-Chlorobenzenesulfonyl chloride 
               
               
                   
                 DKC1125c22 
                 Benzenesulfonyl chloride 
               
               
                   
                 DKC1125c23 
                 a-Toluenesulfonyl chloride 
               
               
                   
                 DKC1125c24 
                 4-Methoxybenzenesulfonyl chloride 
               
               
                   
                 DKC1125c25 
                 2-(Trifluoromethyl)benzoyl chloride 
               
               
                   
                 DKC1125c26 
                 3-(Trifluoromethyl)benzoyl chloride 
               
               
                   
                 DKC1125c27 
                 4-(Trifluoromethyl)benzoyl chloride 
               
               
                   
                 DKC1125c28 
                 2-Chloro-4-fluorobenzoyl chloride 
               
               
                   
                 DKC1125c29 
                 3,4-Difluorobenzoyl chloride 
               
               
                   
                 DKC1125c30 
                 3,5-Dichlorobenzoyl chloride 
               
               
                   
                 DKC1125c31 
                 2,3-Dichlorobenzoyl chloride 
               
               
                   
                 DKC1125c32 
                 4-(Trifluoromethoxy)benzoyl chloride 
               
               
                   
                 DKC1125c33 
                 3,5-Dimethylbenzoyl chloride 
               
               
                   
                 DKC1125c34 
                 3,5-Dimethoxybenzoyl chloride 
               
               
                   
                   
               
            
           
         
       
     
     Confirmation of Preparation of Compounds 88 to 121 (DKC1125c01 to 34) 
     4-chloro-N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)benzamide (DKC1125c01)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.90-7.92 (m, 2H), 7.83 (dd, J=6.4, 1.8 Hz, 2H), 7.42-7.44 (m, 3H), 6.68 (d, J=9.1 Hz, 2H), 4.83 (d, J=4.1 Hz, 2H), 3.09 (s, 6H). MS(ESI): m/z 318 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-2-phenoxypropanamide (DKC1125c02)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.85 (dt, J=9.8, 2.5 Hz, 2H), 7.68 (s, 1H), 7.27-7.33 (m, 2H), 6.97-7.01 (m, 3H), 6.64 (dt, J=9.8, 2.5 Hz, 2H), 4.56-4.80 (m, 2H), 3.06 (d, J=7.3 Hz, 6H), 1.62 (d, J=6.4 Hz, 3H). MS(ESI): m/z 327 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-2-fluorobenzamide (DKC1125c03)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.12 (td, J=7.8, 1.8 Hz, 1H), 8.01-8.04 (m, 1H), 7.93 (dt, J=9.6, 2.5 Hz, 2H), 7.46-7.52 (m, 1H), 7.25-7.29 (m, 1H), 7.14-7.19 (m, 1H), 6.66-6.70 (m, 2H), 4.89-4.90 (m, 2H), 3.08 (s, 6H). MS(ESI): m/z 301 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-4-fluorobenzamide (DKC1125c04)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.87-7.94 (m, 4H), 7.42 (d, J=11.0 Hz, 1H), 7.11-7.16 (m, 2H), 6.68 (dd, J=12.1, 3.0 Hz, 2H), 4.84 (d, J=4.1 Hz, 2H), 3.11 (d, J=15.1 Hz, 6H). MS(ESI): m/z 301 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)furan-2-carboxamide (DKC1125c05)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.90-7.93 (m, 2H), 7.56 (s, 1H), 7.50 (t, J=0.9 Hz, 1H), 7.15 (d, J=3.7 Hz, 1H), 6.67-6.70 (m, 2H), 6.51 (q, J=1.7 Hz, 1H), 4.82 (d, J=4.1 Hz, 2H), 3.09 (s, 6H). MS(ESI): m/z 273 (M+1). 
     2-chloro-N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)benzamide (DKC1125c06)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.90-7.93 (m, 2H), 7.72 (dd, J=7.5, 2.1 Hz, 1H), 7.54 (s, 1H), 7.31-7.45 (m, 3H), 6.67-6.70 (m, 2H), 4.88 (d, J=4.1 Hz, 2H), 3.09 (s, 6H). MS(ESI): m/z 318 (M+1). 
     3-chloro-N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)benzamide (DKC1125c07)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.88-7.94 (m, 3H), 7.75 (dt, J=7.8, 1.4 Hz, 1H), 7.50 (dq, J=8.1, 1.0 Hz, 1H), 7.38-7.44 (m, 2H), 6.68-6.70 (m, 2H), 4.84 (d, J=4.1 Hz, 2H), 3.10 (s, 6H). MS(ESI): m/z 318 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)acrylamide (DKC1125c08)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.86-7.91 (m, 2H), 6.86 (s, 1H), 6.67 (dt, J=9.8, 2.5 Hz, 2H), 6.35 (dd, J=16.9, 1.8 Hz, 1H), 6.25 (dd, J=17.2, 9.8 Hz, 1H), 5.70 (dd, J=10.1, 1.8 Hz, 1H), 4.74 (d, J=4.1 Hz, 2H), 3.09 (s, 6H). MS(ESI): m/z 233 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-2-methylbenzamide (DKC1125c09)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.91 (dt, J=9.8, 2.5 Hz, 2H), 7.49 (d, J=7.3 Hz, 1H), 7.33 (td, J=7.5, 1.5 Hz, 1H), 7.23-7.26 (m, 2H), 7.04 (s, 1H), 6.66-6.70 (m, 2H), 4.86 (d, J=4.1 Hz, 2H), 3.09 (s, 6H), 2.50 (s, 3H). MS(ESI): m/z 297 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-4-methoxybenzamide (DKC1125c10)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.93 (dt, J=9.6, 2.5 Hz, 2H), 7.42-7.46 (m, 3H), 7.37 (t, J=8.0 Hz, 1H), 7.05-7.08 (m, 1H), 6.69 (dt, J=9.8, 2.3 Hz, 2H), 4.85 (d, J=3.7 Hz, 2H), 3.87 (s, 3H), 3.10 (s, 6H) MS(ESI): m/z 313 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-3-methylbenzamide (DKC1125c11)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.91-7.94 (m, 2H), 7.69 (dd, J=8.2, 6.4 Hz, 2H), 7.44 (s, 1H), 7.32-7.37 (m, 2H), 6.69 (d, J=9.1 Hz, 2H), 4.85 (d, J=3.7 Hz, 2H), 3.11 (d, J=14.6 Hz, 6H), 2.40 (d, J=14.2 Hz, 3H). MS(ESI): m/z 297 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)propionamide (DKC1125c12)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.86-7.92 (m, 2H), 6.65-6.71 (m, 3H), 4.66 (d, J=4.1 Hz, 2H), 3.08 (t, J=15.3 Hz, 6H), 2.34 (q, J=7.6 Hz, 2H), 1.18-1.25 (m, 3H). MS (ESI): m/z 235 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)cyclopropanecarboxamide (DKC1125c13)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.86-7.91 (m, 2H), 6.86 (s, 1H), 6.67 (dt, J=9.8, 2.5 Hz, 2H), 4.68 (d, J=4.3 Hz, 2H), 3.08 (s, 6H), 1.54 (tt, J=8.4, 3.8 Hz, 1H), 1.00 (dt, J=8.1, 3.3 Hz, 2H), 0.78 (dt, J=11.6, 3.4 Hz, 2H). MS(ESI): m/z 247 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)thiophene-2-carboxamide (DKC1125c14)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.92 (dt, J=9.6, 2.4 Hz, 2H), 7.63 (dd, J=3.9, 1.1 Hz, 1H), 7.50 (dd, J=5.0, 0.9 Hz, 1H), 7.29 (s, 1H), 7.11 (dd, J=5.0, 3.7 Hz, 1H), 6.68 (dt, J=9.8, 2.3 Hz, 2H), 4.83 (d, J=4.1 Hz, 2H), 3.09 (s, 6H). MS(ESI): m/z 289 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-3,3-dimethylbutanamide (DKC1125c15)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.87 (dt, J=9.6, 2.5 Hz, 2H), 6.66 (dt, J=9.8, 2.5 Hz, 2H), 6.61 (s, 1H), 4.67 (d, J=4.1 Hz, 2H), 3.07 (d, J=8.7 Hz, 6H), 2.19 (s, 2H), 1.07 (s, 9H). MS(ESI): m/z 277 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)pentanamide (DKC1125c16)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.87-7.90 (m, 2H), 6.65-6.68 (m, 3H), 4.66 (d, J=4.1 Hz, 2H), 3.08 (s, 6H), 2.30 (t, J=7.5 Hz, 2H), 1.63-1.71 (m, 2H), 1.34-1.41 (m, 3H), 0.93 (t, J=7.3 Hz, 3H). MS(ESI): m/z 263 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-4-methoxybenzamide (DKC1125c17)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.93 (dt, J=9.8, 2.5 Hz, 2H), 7.86 (dt, J=9.5, 2.5 Hz, 2H), 7.36 (s, 1H), 6.93-6.97 (m, 2H), 6.68-6.71 (m, 2H), 4.84 (d, J=4.1 Hz, 2H), 3.87 (d, J=4.1 Hz, 3H), 3.09 (s, 6H). MS(ESI): m/z 313 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-2,4ifluorobenzamide (DKC1125c18)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.15 (td, J=8.9, 6.7 Hz, 1H), 7.91-7.97 (m, 3H), 6.98-7.02 (m, 1H), 6.89-6.95 (m, 1H), 6.69 (dt, J=9.8, 2.3 Hz, 2H), 4.88-4.89 (m, 2H), 3.10 (s, 6H). MS(ESI): m/z 319 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-2-methoxyacetamide (DKC1125c19)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.88 (dt, J=9.8, 2.5 Hz, 2H), 7.64 (s, 1H), 6.67 (dt, J=9.6, 2.4 Hz, 2H), 4.70 (d, J=4.6 Hz, 2H), 3.98 (s, 2H), 3.48 (s, 3H), 3.08 (s, 6H). MS(ESI): m/z 251 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-4-fluorobenzenesulfonamide (DKC1125c20)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.88-7.94 (m, 2H), 7.73 (dt, J=9.8, 2.5 Hz, 2H), 7.13-7.18 (m, 2H), 6.60-6.63 (m, 2H), 5.83 (t, J=4.1 Hz, 1H), 4.35 (d, J=4.1 Hz, 2H), 3.02-3.09 (m, 6H). MS(ESI): m/z 337 (M+1). 
     4-chloro-N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)benzenesulfonamide (DKC1125c21)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.83 (dt, J=9.0, 2.3 Hz, 2H), 7.72 (dt, J=9.8, 2.5 Hz, 2H), 7.45 (dt, J=9.0, 2.3 Hz, 2H), 6.61 (dt, J=9.7, 2.5 Hz, 2H), 5.85 (t, J=4.1 Hz, 1H), 4.35 (d, J=4.1 Hz, 2H), 3.02-3.09 (m, 6H). MS(ESI): m/z 354 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)benzenesulfonamide (DKC1125c22)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.88-7.93 (m, 2H), 7.73 (dt, J=9.6, 2.4 Hz, 2H), 7.46-7.57 (m, 3H), 6.59-6.63 (m, 2H), 5.82 (t, J=3.9 Hz, 1H), 4.35 (d, J=4.6 Hz, 2H), 3.02-3.07 (m, 6H). MS(ESI): m/z 319 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-1-phenylmethanesulfonamide (DKC1125c23)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.67-7.71 (m, 2H), 7.39-7.43 (m, 2H), 7.32-7.34 (m, 3H), 6.60-6.64 (m, 2H), 5.46 (t, J=4.1 Hz, 1H), 4.33 (d, J=8.7 Hz, 2H), 4.23 (d, J=4.1 Hz, 2H), 3.08 (s, 6H). MS(ESI): m/z 333 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-4-methoxybenzenesulfonamide (DKC1125c24)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.80 (dt, J=9.5, 2.5 Hz, 2H), 7.71 (dt, J=9.9, 2.4 Hz, 2H), 6.92 (dt, J=9.5, 2.5 Hz, 2H), 6.58-6.61 (m, 2H), 5.73 (t, J=4.3 Hz, 1H), 4.31 (d, J=4.6 Hz, 2H), 3.81 (s, 3H), 3.02 (d, J=17.4 Hz, 6H). MS(ESI): m/z 349 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-2-(trifluoromethyl)benzamide (DKC1125c25)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.91 (dt, J=9.6, 2.4 Hz, 2H), 7.72-7.75 (m, 1H), 7.61-7.65 (m, 2H), 7.55-7.60 (m, 1H), 7.11 (s, 1H), 6.69 (dt, J=9.8, 2.5 Hz, 2H), 4.87 (d, J=4.1 Hz, 2H), 3.10 (d, J=6.4 Hz, 6H). MS(ESI): m/z 351 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-3-(trifluoromethyl)benzamide (DKC1125c26)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.18 (s, 1H), 8.07 (d, J=7.8 Hz, 1H), 7.94 (dt, J=9.8, 2.3 Hz, 2H), 7.79 (d, J=7.8 Hz, 1H), 7.62 (t, J=7.8 Hz, 1H), 7.51 (s, 1H), 6.71 (dt, J=9.8, 2.5 Hz, 2H), 4.87 (d, J=4.1 Hz, 2H), 3.11 (s, 6H). MS(ESI): m/z 351 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-4-(trifluoromethyl)benzamide (DKC1125c27)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.00 (d, J=8.2 Hz, 2H), 7.92 (dd, J=7.1, 2.1 Hz, 2H), 7.73 (d, J=7.8 Hz, 2H), 7.52 (s, 1H), 6.68-6.70 (m, 2H), 4.86 (d, J=4.1 Hz, 2H), 3.10 (s, 6H). MS(ESI): m/z 351 (M+1). 
     2-chloro-N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-4-fluorobenzamide (DKC1125c28)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.90-7.93 (m, 2H), 7.79 (dd, J=8.5, 6.2 Hz, 1H), 7.58 (s, 1H), 7.19 (dd, J=8.5, 2.5 Hz, 1H), 7.05-7.10 (m, 1H), 6.69 (dd, J=9.4, 2.5 Hz, 2H), 4.88 (d, J=4.1 Hz, 2H), 3.10 (d, J=3.7 Hz, 6H). MS(ESI): m/z 336 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-3,4ifluorobenzamide (DKC1125c29)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.90-7.93 (m, 2H), 7.74-7.79 (m, 1H), 7.64 (tt, J=6.1, 2.0 Hz, 1H), 7.42 (s, 1H), 7.22-7.29 (m, 1H), 6.68-6.71 (m, 2H), 4.83-4.89 (m, 2H), 3.13 (d, J=15.1 Hz, 5H). MS(ESI): m/z 319 (M+1). 
     3,5-dichloro-N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)benzamide (DKC1125c30)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.93 (dt, J=9.8, 2.5 Hz, 2H), 7.75-7.77 (m, 2H), 7.52 (q, J=2.3 Hz, 1H), 7.42 (s, 1H), 6.68-6.72 (m, 2H), 4.83 (d, J=3.7 Hz, 2H), 3.10-3.15 (m, 6H). MS(ESI): m/z 352 (M+1). 
     2,3-dichloro-N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)benzamide (DKC1125c31)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.91 (dt, J=9.8, 2.5 Hz, 2H), 7.54 (ddd, J=10.6, 7.9, 1.5 Hz, 2H), 7.33 (s, 1H), 7.27-7.31 (m, 1H), 6.69 (dt, J=9.6, 2.5 Hz, 2H), 4.88 (d, J=4.1 Hz, 2H), 3.11 (s, 6H). MS (ESI): m/z 352 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-4-(trifluoromethoxy)benzamide (DKC1125c32)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.91-7.97 (m, 4H), 7.45 (s, 1H), 7.30-7.32 (m, 2H), 6.70 (dt, J=9.8, 2.5 Hz, 2H), 4.85 (d, J=4.1 Hz, 2H), 3.11 (s, 6H). MS(ESI): m/z 367 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-3,5-dimethylbenzamide (DKC1125c33)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.91-7.95 (m, 2H), 7.49 (s, 2H), 7.42 (d, J=3.7 Hz, 1H), 7.15 (s, 1H), 6.69 (dd, J=11.9, 2.7 Hz, 2H), 4.84 (d, J=4.1 Hz, 2H), 3.11 (d, J=15.1 Hz, 6H), 2.34-2.37 (m, 6H) MS(ESI): m/z 311 (M+1). 
     N-(2-(4-(dimethylamino)phenyl)-2-oxoethyl)-3,5imethoxybenzamide (DKC1125c34)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.93 (dd, J=11.9, 2.7 Hz, 2H), 7.39 (s, 1H), 7.01 (d, J=2.3 Hz, 2H), 6.69 (dd, J=11.9, 2.7 Hz, 2H), 6.60 (t, J=2.3 Hz, 1H), 4.84 (d, J=4.1 Hz, 2H), 3.83-3.89 (m, 6H), 3.10 (s, 6H). MS(ESI): m/z 343 (M+1). 
     Examples 122 to 129. Preparation of Compounds 122 to 129 (DKC1125d01 to 08) According to the Present Invention 
     Compounds 122 to 129 (DKC1125d01 to 08) of the present invention were synthesized according to the following Reaction Scheme 3. 
     
       
         
         
             
             
         
       
     
     Synthesis of 2-amino-1-(3-methoxyphenyl)ethan-1-one hydrochloride (3) 
     2-bromo-1-(3-methoxyphenyl)ethan-1-one (5 g, 21.83 mmol) was dissolved in 25 mL of CH 2 Cl 2  and treated with hexamethylenetetramine (3.06 g, 21.83 mmol). After overnight at room temperature, the reaction product was cooled with an ice bath and the formed precipitate was washed with CH 2 Cl 2  and EtOH to obtain the hexamethylenetetramine salt. The desired amine was obtained by treating the salt with a solution (90 mL) of concentrated HCl and EtOH (1:2). The formed precipitate was filtered out and washed with water and then EtOH (2.95 g, 65%). 
       1 H NMR (400 MHz, (CD 3 ) 2 SO) δ 8.50 (s, 3H), 7.61 (dd, J=0.9, 7.8 Hz, 1H), 7.50-7.53 (m, 2H), 7.31 (m, 1H), 4.58 (d, J=4.4 Hz, 2H), 3.85 (s, 3H). 
     General Preparation Method for Compounds 122 to 129 (DKC1125d01 to 08) 
     CH 2 Cl 2  (1 mL) and saturated NaHCO 3  (2 mL) were stirred vigorously and chilled in an ice bath. Each acid chloride (0.29 mmol) described in Table 5 below was added, followed immediately by addition of 2-amino-1-(3-methoxyphenyl)ethan-1-one hydrochloride (3, 50 mg, 0.29 mmol). Stirring was continued while warming to room temperature over a period of 1 hour. The organic layer was then separated, and dried with Na 2 SO 4 , and the solvent was evaporated (yield: 80 to 90%). 
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 Acid chlorides used in preparation of 122 to 129 
               
               
                 (DKC1125d01 to 08) 
               
            
           
           
               
               
               
            
               
                   
                 Compounds 
                 Acid chloride 
               
               
                   
                   
               
               
                   
                 DKC1125d01 
                 4-Chlorobenzoyl chloride 
               
               
                   
                 DKC1125d02 
                 Crotonyl chloride 
               
               
                   
                 DKC1125d03 
                 Propionyl chloride 
               
               
                   
                 DKC1125d04 
                 Cyclopropanecarbonylchloride 
               
               
                   
                 DKC1125d05 
                 Cyclobutanecarbonyl chloride 
               
               
                   
                 DKC1125d06 
                 Thiophene-2-carbonyl chloride 
               
               
                   
                 DKC1125d07 
                 Pentanoyl chloride 
               
               
                   
                 DKC1125d08 
                 Benzenesulfonyl chloride 
               
               
                   
                   
               
            
           
         
       
     
     Confirmation of Preparation of Compounds 122 to 129 (DKC1125d01 to 08) 
     4-chloro-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (DKC1125d01)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.83 (dd, J=8.7, 2.3 Hz, 2H), 7.61 (dd, J=7.7, 0.8 Hz, 1H), 7.52-7.54 (m, 2H), 7.44 (dd, J=8.2, 1.8 Hz, 3H), 7.29 (s, 1H), 7.19 (dd, J=8.2, 2.7 Hz, 1H), 4.94 (d, J=4.1 Hz, 2H). MS(ESI): m/z 305 (M+1). 
     (E)-N-(2-(3-methoxyphenyl)-2-oxoethyl)but-2-enamide (DKC1125d02)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.58 (d, J=7.8 Hz, 1H), 7.50 (t, J=2.1 Hz, 1H), 7.41 (t, J=8.0 Hz, 1H), 7.17 (dd, J=8.0, 2.5 Hz, 1H), 6.92 (q, J=7.3 Hz, 1H), 5.98 (dd, J=15.3, 1.6 Hz, 1H), 4.83 (d, J=4.1 Hz, 2H), 3.87 (s, 3H), 1.89 (dd, J=6.9, 1.4 Hz, 3H), 1.61 (d, J=6.4 Hz, 1H). MS(ESI): m/z 234 (M+1). 
     N-(2-(3-methoxyphenyl)-2-oxoethyl) propionamide (DKC1125d03)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.64-7.50 (1H), 7.50-7.43 (1H), 7.43-7.33 (1H), 7.20-7.07 (1H), 6.72-6.46 (1H), 4.77-4.68 (2H), 3.87-3.77 (3H), 2.38-2.25 (2H), 1.25-1.08 (3H). MS(ESI): m/z 222 (M+1). 
     N-(2-(3-methoxyphenyl)-2-oxoethyl)cyclopropanecarboxamide (DKC1125d04)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.56 (d, J=7.8 Hz, 1H), 7.49 (t, J=2.1 Hz, 1H), 7.41 (q, J=7.8 Hz, 1H), 7.16 (dd, J=8.2, 2.3 Hz, 1H), 6.79 (s, 1H), 4.78 (d, J=4.1 Hz, 2H), 3.86 (s, 3H), 1.53-1.59 (m, 1H), 0.99-1.04 (m, 2H), 0.78-0.84 (m, 2H) MS (ESI): m/z 234 (M+1). 
     N-(2-(3-methoxyphenyl)-2-oxoethyl)cyclobutanecarboxamide (DKC1125d05)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.56 (dd, J=7.8, 1.4 Hz, 1H), 7.49 (q, J=1.4 Hz, 1H), 7.41 (t, J=8.0 Hz, 1H), 7.16 (dt, J=8.2, 1.4 Hz, 1H), 6.51 (s, 1H), 4.75 (d, J=4.1 Hz, 2H), 3.86 (s, 3H), 3.11-3.20 (m, 1H), 2.29-2.39 (m, 2H), 2.17-2.25 (m, 2H), 1.85-2.05 (m, 2H). MS(ESI): m/z 248 (M+1). 
     N-(2-(3-methoxyphenyl)-2-oxoethyl)thiophene-2-carboxamide (DKC1125d06)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.62 (d, J=3.7 Hz, 1H), 7.59 (d, J=7.8 Hz, 1H), 7.49-7.51 (m, 2H), 7.41 (t, J=8.0 Hz, 1H), 7.17 (dd, J=8.2, 2.7 Hz, 1H), 7.13 (s, 1H), 7.10 (t, J=4.3 Hz, 1H), 4.91 (d, J=4.1 Hz, 2H). MS(ESI): m/z 276 (M+1). 
     N-(2-(3-methoxyphenyl)-2-oxoethyl)pentanamide (DKC1125d07)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.56 (dd, J=6.4, 1.4 Hz, 1H), 7.49 (q, J=1.4 Hz, 1H), 7.40 (t, J=8.0 Hz, 1H), 7.16 (dq, J=8.2, 1.2 Hz, 1H), 6.64 (s, 1H), 4.76 (d, J=4.6 Hz, 2H), 3.86 (s, 3H), 2.32 (t, J=7.8 Hz, 2H), 1.64-1.71 (m, 2H), 1.34-1.41 (m, 2H), 0.94 (t, J=7.3 Hz, 3H). MS(ESI): m/z 250 (M+1). 
     N-(2-(3-methoxyphenyl)-2-oxoethyl)benzenesulfonamide (DKC1125d08)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.89-7.92 (m, 2H), 7.48-7.58 (m, 3H), 7.34-7.42 (m, 3H), 7.14 (dq, J=8.0, 1.2 Hz, 1H), 5.77 (t, J=4.3 Hz, 1H), 4.47 (d, J=4.6 Hz, 2H), 3.83 (s, 3H). MS(ESI): m/z 306 (M+1). 
     Examples 130 to 136. Preparation of Compounds 130 to 129 (DKC1125e01 to 07) According to the Present Invention 
     Synthesis of Compounds 130 to 136 (DKC1125e01 to 07) 
     Compounds 130 to 136 (DKC1125e01-07) of the present invention were synthesized according to the following Reaction Scheme 4. 
     
       
         
         
             
             
         
       
     
     Synthesis of 2-amino-1-(pyridin-3-yl) ethan-1-one hydrochloride (4) 
     2-bromo-1-(pyridin-3-yl)ethan-1-one (5 g, 25.00 mmol) was dissolved in 25 mL of CH 2 Cl 2  and treated with a solution of hexamethylenetetramine (3.50 g, 25.00 mmol) in 25 mL of CH 2 Cl 2 . After overnight at room temperature, the reaction product was cooled with an ice bath and the formed precipitate was washed with CH 2 Cl 2  and EtOH to obtain the hexamethylenetetramine salt. The desired amine was obtained by treating the salt with a solution (90 mL) of concentrated hydrochloric acid and ethanol (1:2). The formed precipitate was filtered out and washed with water and then ethanol to obtain the title compound (1.30 g, 30%). 
       1 H-NMR (400 MHz, (CD 3 ) 2 SO) δ 9.24 (t, J=1.1 Hz, 1H), 8.93 (q, J=2.3 Hz, 1H), 8.57 (s, 2H), 8.49 (dt, J=8.1, 1.9 Hz, 1H), 7.73-7.76 (m, 1H), 4.67 (d, J=5.5 Hz, 2H). 
     General Preparation Method for Compounds 130 to 136 (DKC1125e01 to 07) 
     CH 2 Cl 2  (1 mL) and saturated NaHCO 3  (2 mL) were stirred vigorously and chilled in an ice bath. Each acid chloride (0.29 mmol) described in Table 6 below was added, followed immediately by addition of 2-amino-1-(pyridin-3-yl)ethan-1-one hydrochloride (4, 50 mg, 0.29 mmol). Stirring was continued while warming to room temperature over a period of 1 hour. The organic layer was then separated, and dried with Na 2 SO 4 , and the solvent was evaporated. The residue was purified by column chromatography (yield: 30 to 40%). 
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 Acid chlorides used in preparation  
               
               
                 of compounds 130 to 136 
               
               
                 (DKC1125e01 to 07) 
               
            
           
           
               
               
               
            
               
                   
                 Compounds 
                 Acid chloride 
               
               
                   
                   
               
               
                   
                 DKC1125e01 
                 4-Chlorobenzoyl chloride 
               
               
                   
                 DKC1125e02 
                 2-Phenoxypropiony chloride 
               
               
                   
                 DKC1125e03 
                 2-Fluorobenzoyl chloride 
               
               
                   
                 DKC1125e04 
                 4-Fluorobenzoyl chloride 
               
               
                   
                 DKC1125e05 
                 Crotonyl chloride 
               
               
                   
                 DKC1125e06 
                 o-Toluoyl chloride 
               
               
                   
                 DKC1125e07 
                 Propionyl chloride 
               
               
                   
                   
               
            
           
         
       
     
     Confirmation of Preparation of Compounds 130 to 136 (DKC1125e01 to 07) 
     4-chloro-N-(2-oxo-2-(pyridin-3-yl)ethyl)benzamide (DKC1125e01)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.23 (s, 1H), 8.84 (d, J=3.7 Hz, 1H), 8.27 (dt, J=7.9, 1.9 Hz, 1H), 7.80 (dt, J=9.0, 2.1 Hz, 2H), 7.47 (dd, J=8.0, 4.8 Hz, 1H), 7.42 (dt, J=9.0, 2.1 Hz, 2H), 7.25 (s, 1H), 4.95 (d, J=4.6 Hz, 2H). MS(ESI): m/z 276 (M+1). 
     N-(2-oxo-2-(pyridin-3-yl)ethyl)-2-phenoxypropanamide (DKC1125e02)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.18 (d, J=1.8 Hz, 1H), 8.83 (dd, J=4.8, 1.6 Hz, 1H), 8.24 (dt, J=7.8, 1.8 Hz, 1H), 7.45-7.51 (m, 2H), 7.31 (t, J=8.0 Hz, 2H), 6.96-7.04 (m, 3H), 4.68-4.87 (m, 3H), 1.63 (d, J=6.9 Hz, 3H) MS(ESI): m/z 285 (M+1). 
     2-fluoro-N-(2-oxo-2-(pyridin-3-yl)ethyl)benzamide (DKC1125e03)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.27 (s, 1H), 8.87 (d, J=3.7 Hz, 1H), 8.32 (dt, J=8.2, 1.8 Hz, 1H), 8.11 (td, J=8.0, 1.8 Hz, 1H), 7.84 (d, J=11.9 Hz, 1H), 7.49-7.54 (m, 2H), 7.26-7.30 (m, 1H), 7.18 (ddd, J=11.9, 8.2, 0.9 Hz, 1H), 5.02-5.03 (m, 2H). MS(ESI): m/z 259 (M+1). 
     4-fluoro-N-(2-oxo-2-(pyridin-3-yl)ethyl)benzamide (DKC1125e04)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.22 (s, 1H), 8.83 (d, J=3.7 Hz, 1H), 8.27 (dt, J=8.2, 1.8 Hz, 1H), 7.85-7.88 (m, 2H), 7.46 (q, J=4.1 Hz, 1H), 7.24 (d, J=4.1 Hz, 1H), 7.09-7.13 (m, 2H), 4.94 (d, J=4.6 Hz, 2H). MS(ESI): m/z 259 (M+1). 
     (E)-N-(2-oxo-2-(pyridin-3-yl)ethyl)but-2-enamide (DKC1125e05)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.32-9.09 (1H), 8.92-8.71 (1H), 8.35-8.16 (1H), 7.60-7.35 (1H), 6.96-6.84 (1H), 6.00-5.89 (1H), 4.88-4.81 (2H), 1.92-1.75 (3H). MS(ESI): m/z 205 (M+1). 
     2-methyl-N-(2-oxo-2-(pyridin-3-yl)ethyl)benzamide (DKC1125e06)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.24 (d, J=1.8 Hz, 1H), 8.86 (dd, J=4.8, 1.1 Hz, 1H), 8.30 (dt, J=7.9, 1.9 Hz, 1H), 7.50 (q, J=4.1 Hz, 2H), 7.34-7.38 (m, 1H), 7.23-7.27 (m, 2H), 6.88 (s, 1H), 4.98 (d, J=4.6 Hz, 2H), 2.50 (s, 3H). MS(ESI): m/z 255 (M+1). 
     N-(2-oxo-2-(pyridin-3-yl)ethyl) propionamide (DKC1125e07)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.21 (d, J=2.3 Hz, 1H), 8.85 (dd, J=4.8, 1.6 Hz, 1H), 8.27 (dt, J=8.1, 1.9 Hz, 1H), 7.46-7.50 (m, 1H), 6.57 (s, 1H), 4.80 (d, J=4.1 Hz, 2H), 2.37 (q, J=7.6 Hz, 2H), 1.20-1.26 (m, 3H). MS(ESI): m/z 193 (M+1). 
     Examples 137 to 150. Preparation of Compounds 137 to 150 (DKC1125f01 to 14) According to the Present Invention 
     Synthesis of Compounds 137-150 (DKC1125f01 to 14) 
     Compounds 137 to 140 (DKC1125f01 to 14) of the present invention were synthesized according to the following Reaction Scheme 5. 
     
       
         
         
             
             
         
       
     
     Synthesis of 2-bromo-1-(4-morpholinophenyl)ethan-1-one (5) 
     To a solution of 1-(4-morpholinophenyl)ethan-1-one (5 g, 24.36 mmol) in HBr (100 mL) at 0° C. was added Br 2  (3.89 g, 24.36 mmol) dropwise over 1 hour. After the reaction was complete, the product was extracted twice with CH 2 Cl 2  and washed with saturated NaHCO 3 . The organic layer was dried with MgSO 4 , and the solvent was evaporated. The resulting crude product was purified by column chromatography to give compound (1) of Reaction Scheme 5 (6.23 g, 90%). 
       1 H NMR (400 MHz, CDCl 3 ) δ 7.95 (d, J=4.0 Hz, 2H), 7.04 (d, J=4.0 Hz, 2H), 4.60 (s, 2H), 3.83 (m, 4H), 3.65 (m, 4H). 
     Synthesis of 2-Amino-1-[4-(morpholin-4-yl)phenyl]ethan-1-one dihydrochloride (6) 
     The 2-bromo-1-(4-morpholinophenyl)ethan-1-one (5, 6 g, 21.11 mmol) was dissolved in 20 mL of dry potassium phthalimide solution (4.30 g, 23.22 mmol), and held at 75° C. for 18 hrs. The suspension was quenched in 90 mL of water with stirring, which was maintained for 40 min, and the product was collected, washed with 50 mL of water, and recrystallized from 50 mL of acetonitrile at 0° C. overnight. (4.58 g, 60%). The solid was dissolved in a solution (90 mL) of concentrated HCl and EtOH (1:2). The reaction product was boiled under reflux for 2 hrs. The precipitate was filtered out and washed with water and then EtOH (3.79 g, 70%). 
       1 H-NMR (400 MHz, (CD 3 ) 2 SO) δ 1.87 (d, J=9.0 Hz, 2H), 7.03 (d, J=9.0 Hz, 2H), 4.45 (d, J=4.5 Hz, 2H), 3.73 (dd, J=4.0, 5.0 Hz, 4H), 3.35 (dd, J=4.0, 5.0 Hz, 4H). 
     General Preparation Method for Compounds 137 to 150 (DKC1125f01 to 14) 
     CH 2 Cl 2  (1 mL) and saturated NaHCO 3  (2 mL) were stirred vigorously and chilled in an ice bath. Each acid chloride (0.29 mmol) shown in Table 7 below was added, followed immediately by addition of 2-amino-1-(4-morpholinophenyl)ethan-1-one dihydrochloride (6, 50 mg, 0.29 mmol). Stirring was continued while warming to room temperature over a period of 1 hr. The organic layer was then separated, and dried with Na 2 SO 4 , and the solvent was evaporated. The residue was purified by column chromatography (yield: 65 to 80%). 
     
       
         
           
               
             
               
                 TABLE 7 
               
             
            
               
                   
               
               
                 Acid chlorides used in preparation  
               
               
                 of compounds 137 to 150 
               
               
                 (DKC1125f01 to 14) 
               
            
           
           
               
               
               
            
               
                   
                 Compounds 
                 Acid chloride 
               
               
                   
                   
               
               
                   
                 DCK1125f01 
                 2-Fluorobenzoyl chloride 
               
               
                   
                 DCK1125f02 
                 2-Chlorobenzoyl Chloride 
               
               
                   
                 DCK1125f03 
                 Crotonyl chloride 
               
               
                   
                 DCK1125f04 
                 3-Methoxybenzoyl chloride 
               
               
                   
                 DCK1125f05 
                 m-Toluoyl chloride 
               
               
                   
                 DCK1125f06 
                 Propionyl chloride 
               
               
                   
                 DCK1125f07 
                 Cyclopropanecarbonylchloride 
               
               
                   
                 DCK1125f08 
                 Cyclobutanecarbonyl chloride 
               
               
                   
                 DCK1125f09 
                 Pentanoyl chloride 
               
               
                   
                 DCK1125f10 
                 4-Fluorobenzenesulfonyl chloride 
               
               
                   
                 DCK1125f11 
                 4-Chlorobenzenesulfonyl chloride 
               
               
                   
                 DCK1125f12 
                 Benzenesulfonyl chloride 
               
               
                   
                 DCK1125f13 
                 a-Toluenesulfonyl chloride 
               
               
                   
                 DCK1125f14 
                 4-Methoxybenzenesulfonyl chloride 
               
               
                   
                   
               
            
           
         
       
     
     Confirmation of Preparation of Compounds 137 to 150 (DKC1125f01 to 14) 
     2-fluoro-N-(2-(4-morpholinophenyl)-2-oxoethyl)benzamide (DKC1125f01)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.13 (td, J=7.8, 1.8 Hz, 1H), 7.95-7.99 (m, 3H), 7.48-7.53 (m, 1H), 7.26-7.30 (m, 1H), 7.16-7.21 (m, 1H), 6.91 (dt, J=9.6, 2.4 Hz, 2H), 4.92 (dd, J=4.1, 0.9 Hz, 2H), 3.88 (t, J=5.0 Hz, 4H), 3.36 (t, J=4.8 Hz, 4H). MS (ESI): m/z 343 (M+1). 
     2-chloro-N-(2-(4-morpholinophenyl)-2-oxoethyl)benzamide (DKC1125f02)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.94 (dt, J=9.6, 2.4 Hz, 2H), 7.73 (dd, J=7.8, 1.8 Hz, 1H), 7.49 (s, 1H), 7.32-7.45 (m, 3H), 6.90 (dd, J=11.9, 2.7 Hz, 2H), 4.90 (d, J=4.6 Hz, 2H), 3.86 (t, J=5.0 Hz, 4H), 3.36 (t, J=5.0 Hz, 4H). MS(ESI): m/z 360 (M+1). 
     (E)-N-(2-(4-morpholinophenyl)-2-oxoethyl)but-2-enamide (DKC1125f03)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.92 (d, J=8.7 Hz, 2H), 6.87-6.95 (m, 3H), 6.65 (s, 1H), 5.96 (dd, J=15.3, 1.6 Hz, 1H), 4.75 (d, J=4.1 Hz, 2H), 3.86 (t, J=4.8 Hz, 4H), 3.35 (t, J=4.8 Hz, 4H), 1.89 (d, J=6.9 Hz, 3H). MS(ESI): m/z 289 (M+1). 
     4-methoxy-N-(2-(4-morpholinophenyl)-2-oxoethyl)benzamide (DKC1125f04)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.96 (d, J=9.1 Hz, 2H), 7.33-7.45 (m, 4H), 7.06-7.08 (m, 1H), 6.91 (d, J=8.7 Hz, 2H), 4.87 (d, J=4.1 Hz, 2H), 3.86-3.88 (m, 8H), 3.36 (t, J=5.0 Hz, 3H). MS(ESI): m/z 355 (M+1). 
     3-methyl-N-(2-(4-morpholinophenyl)-2-oxoethyl)benzamide (DKC1125f05)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.97 (d, J=9.1 Hz, 2H), 7.69 (dd, J=8.9, 6.6 Hz, 2H), 7.35-7.38 (m, 3H), 6.92 (d, J=8.7 Hz, 2H), 4.88 (d, J=4.1 Hz, 2H), 3.88 (t, J=4.8 Hz, 4H), 3.37 (t, J=4.8 Hz, 4H), 2.43 (s, 3H). MS(ESI): m/z 339 (M+1). 
     N-(2-(4-morpholinophenyl)-2-oxoethyl)propionamide (DKC1125f06)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.89-7.93 (m, 2H), 6.89 (dt, J=11.9, 2.3 Hz, 2H), 6.65 (s, 1H), 4.69 (d, J=4.1 Hz, 2H), 3.87 (t, J=5.0 Hz, 4H), 3.35 (t, J=5.0 Hz, 4H), 2.35 (q, J=7.6 Hz, 2H), 1.22 (t, J=7.5 Hz, 4H). MS (ESI): m/z 377 (M+1). 
     N-(2-(4-morpholinophenyl)-2-oxoethyl)cyclopropanecarboxamide (DKC1125f07)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.92 (d, J=9.1 Hz, 2H), 6.89 (d, J=9.1 Hz, 2H), 6.81 (s, 1H), 4.71 (d, J=4.1 Hz, 2H), 3.87 (t, J=5.0 Hz, 4H), 3.35 (t, J=5.0 Hz, 4H), 1.52-1.58 (m, 1H), 0.99-1.03 (m, 2H), 0.80 (dt, J=11.6, 3.4 Hz, 2H). MS (ESI): m/z 289 (M+1). 
     N-(2-(4-morpholinophenyl)-2-oxoethyl)cyclobutanecarboxamide (DKC1125f08)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.90-7.93 (m, 2H), 6.89 (dd, J=11.9, 2.7 Hz, 2H), 6.56 (s, 1H), 4.68 (d, J=4.1 Hz, 2H), 3.87 (t, J=5.0 Hz, 4H), 3.35 (t, J=5.0 Hz, 4H), 3.11-3.19 (m, 1H), 2.29-2.39 (m, 2H), 2.17-2.25 (m, 2H), 1.88-2.06 (m, 2H). MS (ESI): m/z 303 (M+1). 
     N-(2-(4-morpholinophenyl)-2-oxoethyl)pentanamide (DKC1125f09)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.91 (d, J=9.1 Hz, 2H), 6.89 (d, J=9.1 Hz, 2H), 6.64 (s, 1H), 4.69 (d, J=4.1 Hz, 2H), 3.87 (t, J=4.8 Hz, 4H), 3.35 (t, J=5.0 Hz, 4H), 2.32 (t, J=7.5 Hz, 2H), 1.64-1.72 (m, 2H), 1.36-1.44 (m, 2H), 0.94 (t, J=7.3 Hz, 3H). MS(ESI): m/z 305 (M+1). 
     4-fluoro-N-(2-(4-morpholinophenyl)-2-oxoethyl)benzenesulfonamide (DKC1125f10)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.92 (qd, J=4.8, 2.5 Hz, 2H), 7.76-7.79 (m, 2H), 7.15-7.20 (m, 2H), 6.83-6.86 (m, 2H), 4.38 (d, J=4.1 Hz, 2H), 3.86 (t, J=4.8 Hz, 4H), 3.34 (t, J=5.0 Hz, 4H). MS(ESI): m/z 379 (M+1). 
     4-chloro-N-(2-(4-morpholinophenyl)-2-oxoethyl)benzenesulfonamide (DKC1125f11)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.82-7.92 (m, 2H), 7.75-7.78 (m, 2H), 7.47 (dt, J=9.1, 2.3 Hz, 2H), 6.82-6.85 (m, 2H), 5.78 (t, J=4.3 Hz, 1H), 4.38 (d, J=4.6 Hz, 2H), 3.84-3.89 (m, 4H), 3.34 (t, J=5.0 Hz, 4H). MS(ESI): m/z 396 (M+1). 
     N-(2-(4-morpholinophenyl)-2-oxoethyl)benzenesulfonamide (DKC1125f12)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.89-7.94 (m, 2H), 7.77 (dd, J=7.1, 2.1 Hz, 2H), 7.48-7.57 (m, 4H), 6.84 (d, J=9.1 Hz, 2H), 4.39 (d, J=4.6 Hz, 2H), 3.84-3.88 (m, 5H), 3.33 (t, J=5.0 Hz, 4H). MS (ESI): m/z 361 (M+1). 
     N-(2-(4-morpholinophenyl)-2-oxoethyl)-1-phenylmethanesulfonamide (DKC1125f13)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.72 (dt, J=9.6, 2.4 Hz, 2H), 7.40-7.45 (m, 2H), 7.33-7.37 (m, 3H), 6.83-6.86 (m, 2H), 4.33 (s, 2H), 4.25 (d, J=4.6 Hz, 2H), 3.87 (t, J=4.8 Hz, 4H), 3.35 (t, J=5.0 Hz, 4H). MS(ESI): m/z 375 (M+1). 
     4-methoxy-N-(2-(4-morpholinophenyl)-2-oxoethyl)benzenesulfonamide (DKC1125f14)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.82 (dt, J=9.5, 2.4 Hz, 2H), 7.76 (d, J=9.1 Hz, 2H), 6.94 (dt, J=9.6, 2.5 Hz, 2H), 6.83 (d, J=9.1 Hz, 2H), 5.72 (t, J=4.1 Hz, 1H), 4.35 (d, J=4.6 Hz, 2H), 3.85 (dd, J=8.9, 3.9 Hz, 7H), 3.32 (t, J=5.0 Hz, 4H). MS(ESI): m/z 391 (M+1). 
     Examples 151 to 200. Preparation of Compounds 151 to 200 (DKC1125 g01 to 50) According to the Present Invention 
     Synthesis of Compounds 151 to 200 (DKC1125 g01 to 50) 
     Compounds 151 to 200 (DKC1125 g01 to 50) of the present invention were synthesized according to the following Reaction Scheme 6. 
     
       
         
         
             
             
         
       
     
     Synthesis of 2-((1-(tert-butoxycarbonyl)) piperidin-4-yl) oxy) benzoic acid (1) 
     To a solution of tert-butyl 4-(2-(methoxycarbonyl)phenoxy)piperidine-1-carboxylate (2.0 g, 5.69 mol) in methanol (20 mL) was added 4N NaOH (6 mL). The resulting solution was stirred at 65° C. for 6 hrs. The reaction monitored by checking TLC. After completion of the reaction, to the resulting mixture added water and HCl to maintain acidic pH, followed by extraction with EA. The organic layer was separated and washed with brine (3×100 mL). The washed solution was dried with anhydrous Na 2 SO 4 , and the solvent was evaporated in vacuum. The residue was purified by column chromatography (EtOAc:Hexane 1:1) to give the title compound (1) as white powder (1.8 g, 90%). 
       1 H-NMR (400 MHz, CDCl 3 ) δ 8.20 (dd, J=7.8, 1.8 Hz, 1H), 7.52-7.57 (m, 1H), 7.12-7.17 (m, 1H), 7.06 (d, J=8.2 Hz, 1H), 4.73-4.79 (m, 1H), 4.09-4.14 (m, 1H), 3.83 (q, J=4.4 Hz, 2H), 3.29 (tt, J=13.3, 4.4 Hz, 2H), 2.04 (d, J=3.7 Hz, 8H), 1.84 (tt, J=13.0, 4.3 Hz, 2H), 1.47 (s, 9H). MS (ESI): m/z 322 (M+1). 
     Synthesis of tert-butyl 4-(2-((2-oxo-2-phenylethyl) carbonyl) phenoxy) piperidine-1-carboxylate (2) 
     To a solution of 2-((1-(tert-butoxycarbonyl))piperidin-4-yl)oxy)benzoic acid (1, 1.0 g, 3.11 mol) (1.0 g, 3.11 mol) and 2-amino-1-phenylethan-1-one (534 mg, 3.11 mol) in DMF (10 mL) was added DIEA (1.3 mL, 7.78 mol) with stirring, followed by addition of HATU (1.1 g, 3.11 mmol). The resulting solution was stirred at room temperature for 10 hrs. The reaction was monitored by checking TLC. After completions of reaction, to the resulting mixture was added water, followed by extraction with EA. The organic layer was separated and washed with brine (3×100 mL). The washed solution was dried with anhydrous sodium sulphate, and the solvent was evaporated. The residue was purified by column chromatography (EtOAc: Hexane 2:3) to give the title compound (2) as white powder (1.3 g, 76%). 
       1 H-NMR (400 MHz, CDCl 3 ) δ 9.00 (s, 1H), 8.24 (dd, J=8.0, 2.1 Hz, 1H), 7.63 (tt, J=7.4, 1.4 Hz, 2H), 7.50-7.54 (m, 2H), 7.44 (dd, J=8.7, 1.4 Hz, 2H), 7.02-7.10 (m, 2H), 5.01 (d, J=3.7 Hz, 2H), 4.66-4.71 (m, 1H), 3.95 (s, 2H), 3.17-3.23 (m, 2H), 2.96 (d, J=5.5 Hz, 4H), 1.47 (s, 9H) MS (ESI): m/z 439 (M+1). 
     Synthesis of N-(2-oxo-2-phenylethyl)-2-(piperidin-4-yloxy) benzamine (3) 
     To a solution of tert-butyl 4-(2-((2-oxo-2-phenylethyl) carbonyl) phenyl) piperidine-1-carboxylate (2, 1.0 g, 3.11 mol) in anhydrous dichloromethane (20 mL) was added trifluoroacetic acid (1.3 mL, 7.78 mol) under nitrogen gas. The resulting solution was stirred at room temperature for 2 hrs. After completion of the reaction, the solvent was evaporated from the mixture, and the residue was purified by column chromatography to give the title compound (3) as a yellow solid (0.9 g, 90%). 
       1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.03-8.05 (m, 2H), 7.61-7.65 (m, 1H), 7.50-7.54 (m, 2H), 7.44 (dd, J=8.7, 1.4 Hz, 1H), 7.03-7.09 (m, 2H), 5.30 (s, 1H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 339 (M+1). 
     General Preparation Method for Compounds 150 to 200 (DKC1125 g01 to 50) 
     To a solution of N-(2-oxo-2-phenylethyl)-2-(piperidin-4-yloxy)benzamine (3, 10 mg, 0.029 mmol) and each acid chloride (10 μL, 0.07 mmol) shown in Table 8 below in dichloromethane was added triethylamine (3.7 μL, 0.029 mmol). The reaction mixture was stirred at room temperature for 1 hr. After completion of the reaction, the mixture was evaporated and purified by column chromatography to give (EtOAc: Hexane 1:2) to obtain the title compound as a solid (12 mg, 83%). 
     
       
         
           
               
             
               
                 TABLE 8 
               
             
            
               
                   
               
               
                 Acid chlorides used in preparation of compounds 150 to 200 
               
               
                 (DKC1125g01 to 50) 
               
            
           
           
               
               
               
            
               
                   
                 Compounds 
                 Acid Chloride 
               
               
                   
                   
               
               
                   
                 DKC1125g01 
                 4-Chlorobenzoyl chloride 
               
               
                   
                 DKC1125g02 
                 2-Phenoxypropionyl chloride 
               
               
                   
                 DKC1125g03 
                 2-Fluorobenzoyl chloride 
               
               
                   
                 DKC1125g04 
                 4-Fluorobenzoyl chloride 
               
               
                   
                 DKC1125g05 
                 2-Furoyl chloride 
               
               
                   
                 DKC1125g06 
                 2-Chlorobenzoyl Chloride 
               
               
                   
                 DKC1125g07 
                 3-Chlorobenzoyl chloride 
               
               
                   
                 DKC1125g08 
                 Crotonyl chloride 
               
               
                   
                 DKC1125g09 
                 3-Phenylpropionyl chloride 
               
               
                   
                 DKC1125g10 
                 Acryloyl chloride 
               
               
                   
                 DKC1125g11 
                 o-Toluoyl chloride 
               
               
                   
                 DKC1125g12 
                 3-Methoxybenzoyl chloride 
               
               
                   
                 DKC1125g13 
                 m-Toluoyl chloride 
               
               
                   
                 DKC1125g14 
                 Propionyl chloride 
               
               
                   
                 DKC1125g15 
                 Cyclohexanecarbonyl chloride 
               
               
                   
                 DKC1125g16 
                 Cyclopropanecarbonylchloride 
               
               
                   
                 DKC1125g17 
                 Cyclobutanecarbonyl chloride 
               
               
                   
                 DKC1125g18 
                 Thiophene-2-carbonyl chloride 
               
               
                   
                 DKC1125g19 
                 2-Ethoxybenzoyl chloride 
               
               
                   
                 DKC1125g20 
                 tert-butylacetyl chloride 
               
               
                   
                 DKC1125g21 
                 4-Morpholinecarbonyl chloride 
               
               
                   
                 DKC1125g22 
                 Pentanoyl chloride 
               
               
                   
                 DKC1125g23 
                 4-Methoxybenzoyl chloride 
               
               
                   
                 DKC1125g24 
                 4-Cyanobenzoyl chloride 
               
               
                   
                 DKC1125g25 
                 3-nitrobenzene-1-sulfonyl chloride 
               
               
                   
                 DKC1125g26 
                 O-Acetylsalicyloyl chloride 
               
               
                   
                 DKC1125g27 
                 2,4-Difluorobenzoyl chloride 
               
               
                   
                 DKC1125g28 
                 Methoxyacetyl chloride 
               
               
                   
                 DKC1125g29 
                 Pivaloyl chloride 
               
               
                   
                 DKC1125g30 
                 Dimethylcarbamyl chloride 
               
               
                   
                 DKC1125g31 
                 4-Bromobenzoyl chloride 
               
               
                   
                 DKC1125g32 
                 Acetyl chloride 
               
               
                   
                 DKC1125g33 
                 Methanesulfonyl chloride 
               
               
                   
                 DKC1125g34 
                 4-Fluorobenzenesulfonyl chloride 
               
               
                   
                 DKC1125g35 
                 p-Toluenesulfonyl chloride 
               
               
                   
                 DKC1125g36 
                 4-Chlorobenzenesulfonyl chloride 
               
               
                   
                 DKC1125g37 
                 Benzenesulfonyl chloride 
               
               
                   
                 DKC1125g38 
                 a-Toluenesulfonyl chloride 
               
               
                   
                 DKC1125g39 
                 4-Methoxybenzenesulfonyl chloride 
               
               
                   
                 DKC1125g40 
                 3,5-Bis(trifluoromethyl)benzoyl chloride 
               
               
                   
                 DKC1125g41 
                 2-(Trifluoromethyl)benzoyl chloride 
               
               
                   
                 DKC1125g42 
                 3-(Trifluoromethyl)benzoyl chloride 
               
               
                   
                 DKC1125g43 
                 4-(Trifluoromethyl)benzoyl chloride 
               
               
                   
                 DKC1125g44 
                 2-Chloro-4-fluorobenzoyl chloride 
               
               
                   
                 DKC1125g45 
                 3-Nitrobenzoyl chloride 
               
               
                   
                 DKC1125g46 
                 3,4-Difluorobenzoyl chloride 
               
               
                   
                 DKC1125g47 
                 3,5-Dichlorobenzoyl chloride 
               
               
                   
                 DKC1125g48 
                 2,3-Dichlorobenzoyl chloride 
               
               
                   
                 DKC1125g49 
                 4-(Trifluoromethoxy)benzoyl chloride 
               
               
                   
                 DKC1125g50 
                 3-(Trifluoromethoxy)benzoyl chloride 
               
               
                   
                   
               
            
           
         
       
     
     Confirmation of Preparation of Compounds 150 to 200 (DKC1125 g01 to 50) 
     2-((1-(4-chlorobenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g01)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.28-7.32 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 477 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-((1-(2-phenoxypropanoyl)piperidin-4-yl)oxy)benzamide (DKC1125 g02)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.96 (s, 1H), 8.20 (dd, J=7.8, 1.8 Hz, 1H), 7.80-8.91 (m, 2H), 7.64-7.68 (m, 2H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.28-7.34 (m, 2H), 7.03-7.12 (m, 2H), 5.01 (d, J=4.1 Hz, 2H), 4.7-4.9 (m, 1H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.87 (s, 3H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 487 (M+1). 
     2-((1-(2-fluorobenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g03)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.99 (s, 1H), 8.28 (dd, J=7.8, 1.8 Hz, 1H), 8.30-8.08 (m, 2H), 7.68-7.69 (m, 2H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.28-7.34 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 461 (M+1). 
     2-((1-(4-fluorobenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g04)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 2H), 7.54-7.58 (m, 2H), 7.36-7.43 (m, 2H), 7.28-7.34 (m, 2H), 7.06-7.14 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 461 (M+1). 
     2-((1-(furan-2-carbonyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g05)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.10-8.18 (m, 2H), 7.63-7.67 (m, 2H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.28-7.32 (m, 2H), 7.03-7.12 (m, 1H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 433 (M+1). 
     2-((1-(2-chlorobenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g06)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.61-7.65 (m, 2H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.28-7.32 (m, 2H), 7.06-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 477 (M+1). 
     2-((1-(3-chlorobenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g07)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.20-7.30 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 477 (M+1). 
     (E)-2-((1-(but-2-enoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g08)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.20 (dd, J=7.8, 1.8 Hz, 1H), 8.08-8.12 (m, 2H), 7.61-7.65 (m, 1H), 7.50-7.54 (m, 2H), 7.44 (dd, J=8.7, 1.4 Hz, 1H), 7.03-7.09 (m, 2H), 5.30 (s, 1H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.88 (s, 1H), 2.78-2.84 (m, 1H), 2.6 (s, 3H), 2.17-2.25 (m, 4H), 2.16 (s, 1H), 1.94-2.03 (m, 2H). MS (ESI): m/z 407 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-((1-(3-phenylpropanoyl) piperidin-4-yl)oxy)benzamide (DKC1125 g09)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.95 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.02-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 2H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.22-7.32 (m, 2H), 7.03-7.12 (m, 2H), 5.01 (d, J=4.1 Hz, 2H), 4.60-4.64 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.58-2.70 (m, 2H), 2.54 (d, J=2.4 Hz, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 471 (M+1). 
     2-((1-acryloylpiperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benz amide (DKC1125 g10)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.03-8.05 (m, 2H), 7.61-7.65 (m, 1H), 7.50-7.54 (m, 2H), 7.42 (dd, J=8.6, 1.3 Hz, 1H), 7.03-7.09 (m, 2H), 6.20 (s, 2H), 5.02 (s, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.6 (s, 2H), 2.17-2.25 (m, 4H), 1.94-2.03 (m, 3H). MS (ESI): m/z 393 (M+1). 
     2-((1-(2-methylbenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g11)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.93 (s, 1H), 8.20 (dd, J=7.4, 1.8 Hz, 1H), 8.02-8.06 (m, 2H), 7.62-7.64 (m, 1H), 7.60-7.63 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.20-7.30 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.9 (s, 3H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 457 (M+1). 
     2-((1-(2-methoxybenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g12)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.90 (s, 1H), 8.24 (dd, J=7.8, 1.8 Hz, 1H), 8.01-8.07 (m, 2H), 7.64-7.69 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.20-7.30 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.9 (s, 3H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 473 (M+1). 
     2-((1-(3-methylbenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g13)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.12-8.18 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.22-7.32 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.9 (s, 3H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 457 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-((1-propionylpiperidin-4-yl)oxy)benzamide (DKC1125 g14)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.03-8.05 (m, 2H), 7.61-7.65 (m, 1H), 7.50-7.54 (m, 2H), 7.42 (dd, J=8.6, 1.3 Hz, 1H), 7.03-7.09 (m, 2H), 5.30 (s, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.79 (m, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H), 1.94-2.03 (m, 3H). MS (ESI): m/z 395 (M+1). 
     2-((1-(cyclohexanecarbonyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g15)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.03-8.05 (m, 2H), 7.61-7.65 (m, 1H), 7.50-7.54 (m, 2H), 7.44 (dd, J=8.7, 1.4 Hz, 1H), 7.03-7.09 (m, 2H), 5.30 (s, 1H), 4.61-4.68 (m, 1H), 4.20-4.40 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.88 (s, 2H), 2.78-2.84 (m, 2H), 2.50-2.68 (m, 4H), 2.22-2.46 (m, 2H), 2.17-2.25 (m, 4H), 2.06-2.14 (m, 2H). MS (ESI): m/z 449 (M+1). 
     2-((1-(cyclopropanecarbonyl) piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g16)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.03-8.05 (m, 2H), 7.61-7.65 (m, 1H), 7.50-7.54 (m, 2H), 7.42 (dd, J=8.7, 1.4 Hz, 1H), 7.03-7.09 (m, 2H), 5.30 (s, 2H), 4.61-4.68 (m, 1H), 4.26-4.44 (m, 1H), 3.26-4.10 (m, 2H), 2.78-2.84 (m, 2H), 2.54-2.62 (m, 4H), 2.16-2.24 (m, 4H). MS (ESI): m/z 407 (M+1). 
     2-((1-(cyclobutanecarbonyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g17)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.03-8.05 (m, 2H), 7.61-7.65 (m, 1H), 7.50-7.54 (m, 2H), 7.47 (dd, J=8.7, 1.4 Hz, 1H), 7.03-7.09 (m, 2H), 5.30 (s, 2H), 5.02 (d, J=4.1 Hz, 1H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.40-2.64 (m, 4H), 2.30-2.34 (m, 2H), 2.06-2.14 (m, 4H), MS (ESI): m/z 421 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-((1-(thiophene-2-carbonyl)piperidin-4-yl)oxy)benzamide (DKC1125 g18)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.12-8.16 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.22-7.30 (m, 2H), 7.03-7.12 (m, 1H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 449 (M+1). 
     2-((1-(2-(methoxymethyl)benzoyl) piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g19) H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.12-8.18 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.20-7.29 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.92 (s, 3H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.96 (s, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 487 (M+1). 
     2-((1-(3,3-dimethylbutanoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g20)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.10-8.16 (m, 2H), 7.61-7.65 (m, 1H), 7.50-7.54 (m, 2H), 7.46 (dd, J=8.7, 1.4 Hz 1H), 7.03-7.09 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.9 (m, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). 1.97 (s, 9H). MS (ESI): m/z 437 (M+1). 
     2-((1-(morpholine-4-carbonyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g21)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.03-8.05 (m, 2H), 7.61-7.65 (m, 1H), 7.50-7.54 (m, 2H), 7.44 (dd, J=8.7, 1.4 Hz, 1H), 7.03-7.09 (m, 2H), 5.30 (s, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.8 (m, 2H), 2.78-2.84 (m, 2H), 2.20-2.27 (m, 4H), 2.14-2.18 (m, 2H), 2.10-2.14 (m, 4H). MS (ESI): m/z 452 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-((1-pentanoylpiperidin-4-yl)oxy)benzamide (DKC1125 g22)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.03-8.05 (m, 2H), 7.61-7.65 (m, 1H), 7.50-7.54 (m, 2H), 7.48 (dd, J=8.7, 1.4 Hz, 1H), 7.03-7.09 (m, 2H), 5.30 (s, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.89 (s, 2H), 2.78-2.84 (m, 2H), 2.24-2.29 (m, 2H), 2.17-2.25 (m, 4H), 2.16 (s, 2H), 1.79 (s, 3H). MS (ESI): m/z 523 (M+1). 
     2-((1-(4-methoxybenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g23)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.22-7.28 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.23 (s, 3H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 573 (M+1). 
     2-((1-(4-cyanobenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g24)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.22-7.28 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 471 (M+1). 
     2-((1-((3-(dioxo-15-sulfanyl)phenyl)sulfonyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g25)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.24-7.32 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H) MS (ESI): m/z 542 (M+1). 
     2-(4-(2-((2-oxo-2-phenylethyl) carbamoyl) phenoxy) piperidine-1-carbonyl)phenylacetate (DKC112526 g)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.10-7.34 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 4.21-4.30 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 520 (M+1). 
     2-((1-(2,4-difluorobenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g27)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.20-7.36 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 479 (M+1). 
     2-((1-(2-methoxyacetyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g28)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.03-8.05 (m, 2H), 7.61-7.65 (m, 1H), 7.50-7.54 (m, 2H), 7.44 (ddd, J=8.7, 6.9, 1.4 Hz, 1H), 7.03-7.09 (m, 2H), 5.30 (m, 1H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 2H), 3.97 (s, 3H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 411 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-((1-pivaloylpiperidin-4-yl)oxy)benzamide (DKC1125 g29)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.03-8.05 (m, 2H), 7.61-7.65 (m, 1H), 7.50-7.54 (m, 2H), 7.44 (dd, J=8.7, 1.4 Hz, 1H), 7.03-7.09 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). 1.92 (s, 9H). MS (ESI): m/z 423 (M+1). 
     N,N-dimethyl-4-(2-((2-oxo-2-phenylethyl) carbamoyl) phenoxy) piperidine-1-carboxamide (DKC1125 g30)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.03-8.05 (m, 2H), 7.61-7.65 (m, 1H), 7.50-7.54 (m, 2H), 7.44 (dd, J=8.7, 1.4 Hz, 1H), 7.03-7.09 (m, 2H), 5.30 (s, 2H), 4.61-4.68 (m, 1H), 4.62-4.66 (m, 6H), 3.28 (s, 2H), 2.79 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 410 (M+1). 
     2-((1-(4-bromobenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g31)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.24-7.34 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 521 (M+1). 
     2-((1-acetylpiperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g32)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.03-8.05 (m, 2H), 7.61-7.65 (m, 1H), 7.50-7.54 (m, 2H), 7.44 (dd, J=8.7, 1.4 Hz, 1H), 7.03-7.09 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.9 (s, 3H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 381 (M+1). 
     2-((1-(methylsulfonyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g33)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.03-8.05 (m, 2H), 7.61-7.65 (m, 1H), 7.50-7.54 (m, 2H), 7.44 (dd, J=8.7, 1.4 Hz, 1H), 7.03-7.09 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.8 (s, 3H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 417 (M+1). 
     2-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g34)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.24-7.34 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 497 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-((1-tosylpiperidin-4-yl)oxy)benzamide (DKC1125 g35)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 2H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.24-7.34 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.96 (s, 3H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 493 (M+1). 
     2-((1-((4-chlorophenyl) sulfonyl) piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g36) H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 2H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.24-7.34 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 513 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-((1-(phenylsulfonyl)piperidin-4-yl)oxy)benzamide (DKC1125 g37)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 2H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.24-7.34 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 479 (M+1). 
     2-((1-(benzylsulfonyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g38)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 2H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.2-7.3 (m, 2H), 7.03-7.12 (m, 2H), 5.04 (s, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 457 (456.18+1). MS (ESI): m/z 493 (M+1). 
     2-((1-((4-methoxyphenyl) sulfonyl) piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g39) H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.28-7.30 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.91 (s, 3H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 409 (M+1). 
     2-((1-(3,5-bis(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g40)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.28-7.30 (m, 2H), 7.03-7.12 (m, 1H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 579 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-((1-(2-(trifluoromethyl)benzoyl) piperidin-4-yl)oxy)benzamide (DKC1125 g41)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.28-7.30 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 511 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-((1-(3-(trifluoromethyl)benzoyl) piperidin-4-yl)oxy)benzamide (DKC1125 g42)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.28-7.30 (m, 2H), 7.03-7.12 (m, 2H), 5.40 (d, J=4.2 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 511 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-((1-(4-(trifluoromethyl)benzoyl) piperidin-4-yl)oxy)benzamide (DKC1125 g43)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.22-7.30 (m, 2H), 7.08-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 511 (M+1). 
     2-((1-(2-chloro-4-fluorobenzoyl) piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g44) H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.25-7.32 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 495 (M+1). 
     2-((1-(3-nitrobenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g45)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.62-7.66 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.28-7.30 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 488 (M+1). 
     2-((1-(3,4-difluorobenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g46)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.00-8.08 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.38-7.48 (m, 2H), 7.23-7.34 (m, 2H), 7.03-7.12 (m, 1H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 479 (M+1). 
     2-((1-(3,5-dichlorobenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g47)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.10-8.18 (m, 2H), 7.64-7.68 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.25-7.32 (m, 1H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 511 (M+1). 
     2-((1-(2,3-dichlorobenzoyl)piperidin-4-yl)oxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125 g48)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.22-8.26 (m, 1H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.25-7.32 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 511 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-((1-(4-(trifluoromethoxy)benzoyl) piperidin-4-yl)oxy)benzamide (DKC1125 g49)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.10-8.16 (m, 2H), 7.62-7.64 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.21-7.30 (m, 1H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 527 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-((1-(3-(trifluoromethoxy)benzoyl)piperidin-4-yl)oxy)benzamide (DKC1125 g50)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.98 (s, 1H), 8.25 (dd, J=7.8, 1.8 Hz, 1H), 8.10-8.18 (m, 2H), 7.63-7.67 (m, 1H), 7.61-7.65 (m, 1H), 7.53-7.57 (m, 2H), 7.36-7.43 (m, 2H), 7.21-7.30 (m, 2H), 7.03-7.12 (m, 2H), 5.02 (d, J=4.1 Hz, 2H), 4.61-4.68 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.78-2.84 (m, 2H), 2.17-2.25 (m, 4H). MS (ESI): m/z 527 (M+1). 
     Examples 201 to 230. Preparation of Compounds 201 to 230 (DKC1125h01 to 30) According to the Present Invention 
     Synthesis of Compounds 201 to 230 (DKC1125h01 to 30) 
     Compounds 201 to 230 (DKC1125h01 to 30) of the present invention were synthesized according to the following Reaction Scheme 7. 
     
       
         
         
             
             
         
       
     
     Synthesis of methyl 2-(2((-oxo-2-phenylethyl)carbomyl)phenoxy)acetate (1) 
     To a solution of 2-hydroxy-N-(2-oxo-2-phenylethyl)benzamide (500 mg, 1.97 mmol) and methyl 2-bromoacetate (240 μL, 2.97 mol) in DMF (8 mL) was added potassium carbonate (677 mg, 4.97 mol). The resulting solution was stirred at 50° C. for 9 hrs. The reaction was monitored by checking TLC. After completion of the reaction, to the mixture were added water and HCl to maintain acidic pH, followed by extraction with EtOAc. The organic layer was washed with brine (3×100 mL), and dried the solution with Na 2 SO 4 , and the solvent was evaporated. The residue was purified by column chromatography to give the title compound (1) as a white powder (0.6 g, 84%). 
       1 H-NMR (400 MHz, CDCl 3 ) δ 9.89 (d, J=10.5 Hz, 1H), 8.14-8.20 (m, 1H), 7.74-7.80 (m, 1H), 7.51-7.58 (m, 1H), 7.38-7.49 (m, 2H), 6.96-6.99 (m, 2H), 6.83 (d, J=7.8 Hz, 1H), 6.75 (d, J=8.2 Hz, 1H), 4.74 (d, J=5.9 Hz, 2H), 4.51 (s, 2H), 3.88 (q, J=7.2 Hz, 3H). MS (ESI): m/z 328 (M+1). 
     Synthesis of 2-(2 ((-oxo-2-phenylethyl)carbomyl)phenoxy)acetic acid (2) 
     To a solution of methyl 2-(2((-oxo-2-phenylethyl)carbomyl)phenoxy)acetate (1, 0.6 g, 1.77 mol) in EtOH (10 mL) was added 4N NaOH (6 mL) with stirring, followed by addition of 2N HCl (1 mL). The resulting solution was stirred at room temperature for 4 hrs. The reaction was monitored by checking TLC. After completion of the reaction, to the mixture were added water and HCl to maintain acidic pH, followed by extraction with EA. The organic layer was separated, washed with brine (3×100 mL). The washed solution was dried with anhydrous sodium sulphate, and the solvent was evaporated in vacuo. The residue was purified by column chromatography (EtOAc: Hexane 2:3) to give the title compounds (2) as a white powder (567 mg, 83%). 
       1 H-NMR (400 MHz, CDCl 3 ) δ 9.01 (t, J=5.3 Hz, 1H), 8.03-8.06 (m, 2H), 7.93 (dd, J=7.3, 1.8 Hz, 1H), 7.67-7.71 (m, 2H), 7.55-7.59 (m, 1H), 7.49-7.53 (m, 1H), 7.09-7.14 (m, 2H), 4.93 (s, 2H), 4.87 (d, J=5.5 Hz, 2H). MS (ESI): m/z 314 (M+1). 
     General Preparation Method for Compounds 201 to 230 (DKC1125h01 to 30) 
     To a solution of 2-(2((-oxo-2-phenylethyl)carbomyl)phenoxy)acetic acid (2, 20 mg, 0.069 mmol) and each amine (10 μL, 0.069 mmol) shown in Table 9 below in DMF was added HATU (18 mg, 0.069 mmol). Finally, DIEA (24 μL, 0.143 mmol) was added thereto, and the reaction mixture was stirred at room temperature for 1 hr. After completion of the reaction, the mixture was evaporated by using Rota vapor and purified by column chromatography to obtain the title compound as a solid (12 mg, 80 to 90%). 
     
       
         
           
               
             
               
                 TABLE 9 
               
             
            
               
                   
               
               
                 Amines used in preparation of compounds 201 to 230 
               
               
                 (DKC1125h01 to 30) 
               
            
           
           
               
               
               
            
               
                   
                 Compounds 
                 Amine 
               
               
                   
                   
               
               
                   
                 DKC1125h01 
                 Aniline 
               
               
                   
                 DKC1125h02 
                 o-toluidine 
               
               
                   
                 DKC1125h03 
                 Allylamine 
               
               
                   
                 DKC1125h04 
                 Benzylamine 
               
               
                   
                 DKC1125h05 
                 3-fluorobenzylamine 
               
               
                   
                 DKC1125h06 
                 2-methoxy-5-methylaniline 
               
               
                   
                 DKC1125h07 
                 3-Fluoro-4-methoxyaniline 
               
               
                   
                 DKC1125h08 
                 3-aminopyridine 
               
               
                   
                 DKC1125h09 
                 m-anisidine 
               
               
                   
                 DKC1125h10 
                 2-propylaniline 
               
               
                   
                 DKC1125h11 
                 4-fluoro-3-nitroaniline 
               
               
                   
                 DKC1125h12 
                 3,4-(methylenedioxy)benzylamine 
               
               
                   
                 DKC1125h13 
                 4-n-propylaniline 
               
               
                   
                 DKC1125h14 
                 3-phenoxyaniline 
               
               
                   
                 DKC1125h15 
                 3,4-Dimethoxybenzylamine 
               
               
                   
                 DKC1125h16 
                 3,4-Dimethoxyaniline 
               
               
                   
                 DKC1125h17 
                 3,4-(methylenedioxy)aniline 
               
               
                   
                 DKC1125h18 
                 1,4-benzodioxan-6-amine 
               
               
                   
                 DKC1125h19 
                 5-aminoindane 
               
               
                   
                 DKC1125h20 
                 3-isopropoxyaniline 
               
               
                   
                 DKC1125h21 
                 4-phenoxyaniline 
               
               
                   
                 DKC1125h22 
                 3-Amino-4-fluorobenzotrifluoride 
               
               
                   
                 DKC1125h23 
                 3-aminophenol 
               
               
                   
                 DKC1125h24 
                 2-chloroaniline 
               
               
                   
                 DKC1125h25 
                 2-aminophenol 
               
               
                   
                 DKC1125h26 
                 isopropylamine 
               
               
                   
                 DKC1125h27 
                 1,2,3,4-tetrahydroisoquinoline 
               
               
                   
                 DKC1125h28 
                 1-propylamine 
               
               
                   
                 DKC1125h29 
                 isoamylamine 
               
               
                   
                 DKC1125h30 
                 cyclohexylamine 
               
               
                   
                   
               
            
           
         
       
     
     Confirmation of Preparation of Compounds 201 to 230 (DKC1125h01 to 30) 
     2-(2-oxo-2-(phenylamino) ethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h01)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.76 (s, 1H), 8.48 (s, 1H), 8.01-8.03 (m, 1H), 7.81-7.84 (m, 1H), 7.74-7.77 (m, 2H), 7.49-7.56 (m, 3H), 7.29 (dd, J=7.2, 1.8 Hz, 3H), 7.10-7.15 (m, 2H), 7.05-7.08 (m, 1H), 5.03 (t, J=3.9 Hz, 2H), 4.83 (s, 2H). MS (ESI): m/z 389 (M+1). 
     2-(2-oxo-2-(o-toylamino) ethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h02)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.74 (s, 1H), 8.38 (s, 1H), 8.01-8.03 (m, 2H), 7.81-7.84 (m, 1H), 7.74-7.77 (m, 1H), 7.49-7.56 (m, 3H), 7.29 (dd, J=7.2, 1.8 Hz, 3H), 7.10-7.15 (m, 2H), 7.05-7.08 (m, 1H), 5.03 (t, J=3.9 Hz, 2H), 4.83 (s, 2H), 2.9 (s, 3H). MS (ESI): m/z 403 (M+1). 
     2-(2-(allylamino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h03)  1 H-NMR (400 MHz, CDCl 3 ) 9.70 (s, 1H), 8.64 (s, 1H), 8.02 (d, J=7.3 Hz, 1H), 7.79 (dd, J=7.8, 1.4 Hz, 1H), 7.71 (d, J=3.2 Hz, 3H), 7.52-7.56 (m, 3H), 6.89-6.94 (m, 1H), 5.03 (t, J=3.9 Hz, 2H), 4.83 (s, 2H), 4.66 (s, 1H), 4.04-4.10 (m, 2H), 3.95 (t, J=5.7 Hz, 2H). MS (ESI): m/z 353(M+1). 
     2-(2-(benzylamino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h04)  1 H-NMR (400 MHz, CDCl 3 ) 9.76 (s, 1H), 8.01-8.03 (m, 2H), 7.81-7.84 (m, 1H), 7.74-7.77 (m, 2H), 7.49-7.56 (m, 3H), 7.18 (dd, J=7.2, 1.8 Hz, 3H), 7.10-7.15 (m, 2H), 7.05-7.08 (m, 1H), 5.24 (s, 2H), 5.01 (t, J=3.9 Hz, 2H), 4.67 (s, 2H). MS (ESI): m/z 403(M+1). 
     2-(2-((fluorobenzyl)amino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h05)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.76 (s, 1H), 8.71 (s, 1H), 8.01-8.03 (m, 2H), 7.81-7.84 (m, 1H), 7.74-7.77 (m, 1H), 7.49-7.56 (m, 3H), 7.30 (dd, J=7.4, 1.8 Hz, 3H), 7.10-7.15 (m, 2H), 7.05-7.08 (m, 1H), 5.03 (t, J=3.9 Hz, 2H), 4.83 (s, 2H). MS (ESI): m/z 421(M+1). 
     2-(2-((2-methoxy-4-methylphenyl)amino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h06)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.81 (s, 2H), 8.17 (q, J=2.3 Hz, 1H), 8.14 (dd, J=7.8, 1.8 Hz, 1H), 7.90-7.92 (m, 2H), 7.60-7.64 (m, 1H), 7.46-7.53 (m, 3H), 7.15-7.19 (m, 1H), 7.03 (d, J=8.2 Hz, 1H), 6.82 (dd, J=8.2, 1.4 Hz, 1H), 6.57-6.61 (m, 1H), 5.42 (d, J=4.1 Hz, 2H), 4.79 (s, 2H). 3.96 (s, 3H), 3.12 (s, 1H). MS (ESI): m/z 433 (M+1). 
     2-(2-((3-fluoro-4-methoxyphenyl)amino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h07)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.78 (s, 2H), 8.17 (q, J=2.3 Hz, 2H), 8.15 (dd, J=7.8, 1.8 Hz, 2H), 7.90-7.92 (m, 2H), 7.62-7.64 (m, 2H), 7.03 (d, J=8.2 Hz, 2H), 6.82 (dd, J=8.2, 1.4 Hz, 1H), 6.57-6.61 (m, 1H), 5.03 (d, J=4.1 Hz, 2H), 4.89 (s, 2H), 3.68 (d, J=3.2 Hz, 3H). MS (ESI): m/z 437 (M+1). 
     2-(2-oxo-2-(pyridin-3-ylamino)ethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h08)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.76 (s, 1H), 8.84 (s, 1H), 8.01-8.03 (m, 2H), 7.81-7.84 (m, 1H), 7.74-7.77 (m, 1H), 7.89-7.59 (m, 3H), 7.48-7.42 (dd, J=7.4, 1.8 Hz, 3H), 7.20-7.25 (m, 2H), 7.05-7.08 (m, 1H), 5.47 (t, J=3.9 Hz, 2H), 4.87 (s, 2H). MS (ESI): m/z 390 (M+1). 
     2-(2-((3-methoxyphenyl)amino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h09)  1 H-NMR (400 MHz, CDCl 3 ) 8.62 (s, 1H), 8.17 (q, J=2.3 Hz, 1H), 8.14 (dd, J=7.8, 1.8 Hz, 2H), 7.90-7.92 (m, 2H), 7.60-7.64 (m, 1H), 7.46-7.53 (m, 3H), 7.15-7.19 (m, 1H), 7.03 (d, J=8.2 Hz, 1H), 6.82 (dd, J=8.2, 1.4 Hz, 1H), 6.57-6.61 (m, 1H), 5.03 (d, J=4.1 Hz, 2H), 4.89 (s, 2H), 3.61 (d, J=3.2 Hz, 3H). MS (ESI): m/z 419 (M+1). 
     2-(2-oxo-2-((2-propylphenyl)amino) ethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h10)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.91 (s, 1H), 8.60 (s, 1H), 8.17 (q, J=2.3 Hz, 1H), 8.15 (dd, J=7.8, 1.8 Hz, 2H), 7.90-7.92 (m, 2H), 7.60-7.64 (m, 1H), 7.15-7.19 (m, 1H), 7.03 (d, J=8.2 Hz, 2H), 6.82 (dd, J=8.2, 1.4 Hz, 2H), 6.57-6.61 (m, 2H), 5.03 (d, J=4.1 Hz, 2H), 4.89 (s, 2H), 3.61 (d, J=3.2 Hz, 3H), 2.66-2.72 (m, 2H), 2.42-2.50 (m, 2H). MS (ESI): m/z 431 (M+1). 
     2-(2-((1-fluoro-3-nitrophenyl)amino)-2-oxoethoxy)-N-(2-oxo-2-phenylethylbenzamide (DKC1125h11)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.80 (s, 1H), 8.68 (s, 1H), 8.17 (q, J=2.3 Hz, 2H), 8.14 (dd, J=7.8, 1.8 Hz, 2H), 7.90-7.92 (m, 2H), 7.60-7.64 (m, 1H), 7.05-7.16 (m, 1H), 7.03 (d, J=8.2 Hz, 2H), 6.82 (dd, J=8.2, 1.4 Hz, 1H), 6.57-6.61 (m, 1H), 5.52 (d, J=4.1 Hz, 2H), 4.90 (s, 2H). MS (ESI): m/z 452 (M+1). 
     2-(2-((benzo [1,3]dioxol-5-ylmethyl)amino)-2-oxoethoxy)-N-(2-oxo-2-phenylethylbenzamide (DKC1125h12)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.90 (s, 1H), 8.71 (s, 1H), 8.17 (q, J=2.3 Hz, 1H), 8.14 (dd, J=7.8, 1.8 Hz, 1H), 7.90-7.92 (m, 2H), 7.60-7.64 (m, 1H), 7.46-7.53 (m, 3H), 7.15-7.19 (m, 1H), 7.03 (d, J=8.2 Hz, 1H), 6.82 (dd, J=8.2, 1.4 Hz, 1H), 6.57-6.61 (m, 1H), 6.0 (s, 2H), 5.01 (d, J=4.1 Hz, 2H), 4.68 (s, 2H). MS (ESI): m/z 447 (M+1). 
     2-(2-oxo-2-((4-propylphenyl)amino)ethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h13)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.02 (s, 1H), 8.71 (s, 1H), 8.17 (q, J=2.3 Hz, 1H), 8.03 (dd, J=7.8, 1.8 Hz, 2H), 7.91-7.92 (m, 2H), 7.62-7.64 (m, 1H), 7.44-7.50 (m, 2H), 7.16-7.19 (m, 1H), 7.03 (d, J=8.2 Hz, 1H), 6.82 (dd, J=8.2, 1.4 Hz, 1H), 6.57-6.61 (m, 2H), 5.20 (d, J=4.1 Hz, 2H), 4.54 (s, 2H), 3.61 (d, J=3.2 Hz, 3H). 2.66-2.8 (m, 2H), 2.42-2.48 (m, 2H). MS (ESI): m/z 431 (M+1). 
     2-(2-oxo-2-((3-phenoxyphenyl)amino)ethoxy)-N-(2-oxo-2-phenylethyl)benzamid (DKC1125h14)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.71 (s, 1H), 8.17 (q, J=2.3 Hz, 1H), 8.14 (dd, J=7.8, 1.8 Hz, 1H), 7.90-7.92 (m, 2H), 7.70-7.80 (m, 2H), 7.61-7.64 (m, 2H), 7.50-7.60 (m, 2H), 7.46-7.53 (m, 3H), 7.15-7.19 (m, 2H), 7.03 (d, J=8.2 Hz, 2H), 6.57-6.61 (m, 1H), 5.02 (d, J=4.1 Hz, 2H), 4.67 (s, 2H). MS (ESI): m/z 481 (M+1). 
     2-(2-((3,4-dimethoxybenzyl)amino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h15)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.22 (s, 2H), 8.18 (q, J=2.3 Hz, 2H), 8.12 (dd, J=7.8, 1.8 Hz, 2H), 7.90-7.91 (m, 2H), 7.60-7.64 (m, 1H), 7.15-7.19 (m, 1H), 7.03 (d, J=8.2 Hz, 2H), 6.82 (dd, J=8.2, 1.4 Hz, 1H), 6.57-6.61 (m, 1H), 5.10 (d, J=4.1 Hz, 2H), 4.02 (s, 2H), 3.61 (d, J=3.2 Hz, 3H), 2.31 (d, J=2.3 Hz, 3H). MS (ESI): m/z 463 (M+1). 
     2-(2-((3,4-dimethoxyphenyl)amino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h16)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.20 (s, 2H), 8.17 (q, J=2.3 Hz, 2H), 8.14 (dd, J=7.8, 1.8 Hz, 2H), 7.90-7.92 (m, 2H), 7.60-7.64 (m, 1H), 7.15-7.19 (m, 1H), 7.03 (d, J=8.2 Hz, 2H), 6.82 (dd, J=8.2, 1.4 Hz, 1H), 6.57-6.61 (m, 1H), 5.34 (d, J=4.1 Hz, 2H), 4.33 (s, 2H), 3.61 (d, J=3.2 Hz, 3H), 2.31 (d, J=2.3 Hz, 3H). MS (ESI): m/z 449 (M+1). 
     2-(2-(benzo [d] [1,3]dioxol-5-ylamino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h17)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.90 (s, 1H), 8.71 (s, 1H), 8.17 (q, J=2.3 Hz, 1H), 8.14 (dd, J=7.8, 1.8 Hz, 1H), 7.90-7.92 (m, 2H), 7.60-7.64 (m, 1H), 7.46-7.53 (m, 3H), 7.15-7.19 (m, 1H), 7.03 (d, J=8.2 Hz, 1H), 6.82 (dd, J=8.2, 1.4 Hz, 1H), 6.57-6.61 (m, 1H), 6.0 (s, 2H), 5.01 (d, J=4.1 Hz, 2H), 4.68 (s, 2H). MS (ESI): m/z 433 (M+1). 
     2-(2-((2, 3-dihydrobenzo[b] [1, 4]dioxin-6-yl)amino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h18)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.01 (s, 1H), 8.71 (s, 1H), 8.17 (q, J=2.3 Hz, 1H), 8.14 (dd J=7.8, 1.8 Hz, 1H), 7.90-7.92 (m, 2H), 7.60-7.64 (m, 1H), 7.46-7.53 (m, 3H), 7.15-7.19 (m, 1H), 7.03 (d, J=8.2 Hz, 1H), 6.82 (dd, J=8.2, 1.4 Hz, 1H), 6.57-6.61 (m, 1H), 6.34-6.45 (m, 2H), 6.12-6.23 (m, 2H), 5.43 (d, J=4.1 Hz, 2H), 4.90 (s, 2H). MS (ESI): m/z 447 (M+1). 
     2-(2-((2,3-dihydro-1H-inden-5-yl)amino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h19)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.71 (s, 2H), 8.17 (q, J=2.3 Hz, 1H), 8.14 (dd, J=7.8, 1.8 Hz, 1H), 7.90-7.92 (m, 2H), 7.60-7.64 (m, 1H), 7.46-7.53 (m, 3H), 7.15-7.19 (m, 1H), 7.03 (d, J=8.2 Hz, 1H), 6.82 (dd, J=8.2, 1.4 Hz, 1H), 6.57-6.61 (m, 1H), 5.15 (d, J=4.1 Hz, 2H), 4.78 (s, 2H), 3.60-3.62 (d, J=3.1 Hz, 2H), 3.64-3.66 (d, J=3.4 Hz, 2H), 2.31-2.34 (d, J=2.32 Hz, 2H). MS (ESI): m/z 429 (M+1). 
     2-(2-((3-isopropoxyphenyl)amino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h20)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.12 (s, 1H), 8.43 (s, 1H), 8.01-8.03 (m, 2H), 7.81-7.84 (m, 1H), 7.74-7.77 (m, 1H), 7.49-7.56 (m, 3H), 7.20 (dd, J=7.4, 1.8 Hz, 3H), 7.10-7.15 (m, 2H), 7.05-7.08 (m, 2H), 5.03 (t, J=3.9 Hz, 2H), 4.83 (s, 2H), 4.76-4.80 (m, 3H), 4.32-4.40 (m, 3H). MS (ESI): m/z 447 (M+1). 
     2-(2-oxo-2-((4-phenoxyphenyl)amino)ethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h21)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.31 (s, 1H), 8.17 (q, J=2.3 Hz, 1H), 8.14 (dd, J=7.8, 1.8 Hz, 2H), 7.90-7.92 (m, 2H), 7.80 (dd, J=8.0, 1.8 Hz, 2H), 7.61-7.64 (m, 2H), 7.56 (s, 2H), 7.46-7.53 (m, 3H), 7.32 (d, J=8.2 Hz, 1H), 7.24 (dd, J=6.7, 1.4 Hz, 1H), 6.82 (dd, J=8.2, 1.4 Hz, 1H), 6.57-6.61 (m, 1H), 5.03 (d, J=4.1 Hz, 2H), 4.89 (s, 2H). MS (ESI): m/z 481 (M+1). 
     2-(2-((2-fluoro-5-(trifluoromethyl) phenyl)amino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h22)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.71 (s, 2H), 8.37 (q, J=2.3 Hz, 2H), 8.12-8.18 (dd, J=7.8, 1H), 7.90-7.92 (m, 2H), 7.46-7.53 (m, 3H), 7.15-7.19 (m, 1H), 7.03 (d, J=8.2 Hz, 1H), 6.82 (dd, J=8.2, 1.4 Hz, 1H), 6.57-6.61 (m, 1H), 5.13 (d, J=4.1 Hz, 2H), 4.89 (s, 2H). MS (ESI): m/z 475 (M+1). 
     2-(2-((3-hydroxyphenyl)amino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h23)  1 H-NMR (400 MHz, CDCl 3 ) 9.56 (s, 1H), 8.43 (s, 1H), 8.01-8.03 (dd, J=8.0, 1.4 Hz, 2H), 7.81-7.84 (m, 1H), 7.74-7.77 (m, 1H), 7.49-7.56 (m, 3H), 7.20-7.24 (m, 3H), 7.10-7.15 (m, 2H), 7.05-7.08 (m, 1H), 5.40 (m, 1H), 5.03 (t, J=3.9 Hz, 2H), 4.83 (s, 2H). MS (ESI): m/z 405 (M+1). 
     2-(2-((2-chlorophenyl)amino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h24)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.66 (s, 1H), 8.20 (s, 1H), 8.11-8.13 (m, 2H), 7.81-7.84 (m, 1H), 7.74-7.77 (m, 1H), 7.49-7.56 (m, 3H), 7.29 (dd, J=6.7, 1.8 Hz, 3H), 7.10-7.15 (m, 2H), 7.05-7.08 (m, 1H), 5.24 (t, J=3.9 Hz, 2H), 4.40 (s, 2H). MS (ESI): m/z 423 (M+1). 
     2-(2-((3-bromophenyl)amino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h25)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.76 (s, 1H), 8.39 (s, 1H), 8.01-8.03 (m, 2H), 7.81-7.84 (m, 1H), 7.74-7.77 (m, 2H), 7.49-7.56 (m, 3H), 7.24 (dd, J=6.7, 1.4 Hz, 2H), 7.10-7.15 (m, 2H), 7.05-7.08 (m, 1H), 5.12 (t, J=3.9 Hz, 2H), 4.90 (s, 2H). MS (ESI): m/z 467 (M+1). 
     2-(2-(isopropylamino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h26)  1 H-NMR (400 MHz, CDCl 3 ) δ 9.76 (s, 1H), 8.01-8.03 (s, 1H), 7.81-7.84 (m, 1H), 7.74-7.77 (m, 2H), 7.30-7.34 (m, 2H), 7.10-7.15 (m, 2H), 7.05-7.08 (m, 1H), 6.01-6.1 (m, 1H), 5.03 (t, J=3.9 Hz, 2H), 4.83 (s, 2H), 4.9 (s, 3H), 4.3 (s, 3H). MS (ESI): m/z 355 (M+1). 
     2-(2-(3,4-dihydroisoquinolin-2 (1H)-yl)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h27)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.71 (s, 1H), 8.17 (d, J=2.3 Hz, 1H), 8.14 (dd, J=7.8, 1.8 Hz, 1H), 7.90-7.92 (m, 2H), 7.60-7.64 (m, 1H), 7.46-7.53 (m, 3H), 7.15-7.19 (m, 1H), 7.03 (d, J=8.2 Hz, 1H), 6.82 (dd, J=8.2, 1.4 Hz, 2H), 6.57-6.61 (m, 1H), 5.03 (d, J=4.1 Hz, 2H), 4.89 (s, 2H), 3.60-3.62 (d, J=3.1 Hz, 2H), 3.64-3.66 (d, J=3.4 Hz, 2H), 2.31-2.34 (d, J=2.3 Hz, 2H). MS (ESI): m/z 429 (M+1). 
     2-(2-oxo-2-propylamino)ethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h28)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.39 (s, 1H), 8.02 (d, J=7.3 Hz, 1H), 7.80 (dd, J=7.8, 1.4 Hz, 2H), 7.62 (d, J=3.2 Hz, 3H), 7.56-7.58 (m, 3H), 6.89-6.96 (m, 1H), 5.03 (t, J=3.9 Hz, 2H), 4.83 (s, 2H), 4.04-4.10 (m, 2H), 3.95 (t, J=5.7 Hz, 2H), 3.7 (s, 3H) MS (ESI): m/z 355 (M+1). 
     2-(2-(isopentylamino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h29)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.96 (s, 1H) 8.02 (d, J=7.3 Hz, 1H), 7.72 (dd, J=7.8, 1.4 Hz, 2H), 7.71 (d, J=3.2 Hz, 3H), 7.52-7.56 (m, 3H), 6.89-6.94 (m, 1H), 5.03 (t, J=3.9 Hz, 2H), 4.83 (s, 2H), 4.66 (s, 1H), 4.04-4.10 (m, 2H), 3.95 (t, J=5.7 Hz, 2H), 3.8 (s, 3H), 3.3 (s, 3H). MS (ESI): m/z 383(M+1). 
     2-(2-(cyclohexylamino)-2-oxoethoxy)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125h30)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.02 (d, J=7.3 Hz, 1H), 7.79 (dd, J=7.8, 1.4 Hz, 1H), 7.71 (d, J=3.2 Hz, 3H), 7.52-7.56 (m, 3H), 6.89-6.94 (m, 1H), 5.03 (t, J=3.9 Hz, 2H), 4.83 (s, 2H), 4.42-4.48 (m, 1H), 3.26 (td, J=8.7, 4.3 Hz, 2H), 2.4 (m, 2H), 2.17-2.25 (m, 4H), 2.06-2.14 (m, 2H). MS (ESI): m/z 395 (M+1). 
     Examples 231 to 305. Preparation of Compounds 231 to 305 (DKC1125i01 to 75) According to the Present Invention 
     Synthesis of Compounds 231 to 305 (DKC1125i01 to 75) 
     Compounds 231 to 305 (DKC1125i01-75) of the present invention were synthesized according to the following Reaction Scheme 8. 
     
       
         
         
             
             
         
       
     
     Preparation Method for Bromomethylbenzoyl Chloride (1) 
     SOCl 2  (2 mL, 27.91 mmol) was added dropwise to bromomethylbenzoic acid (1 g, 4.651 mmol) under an anhydrous atmosphere at room temperature. The reaction mixture was stirred under reflux for 4.5 hrs. After completion of the reaction, excess of SOCl 2  was removed by evaporation to obtain bromomethylbenzoyl chloride (1) (1.62 g, 6.95 mmol, 73%) which was used in the next step without any purification. 
     Preparation Method for 3-(bromomethyl)-N-(2-oxo-2-phenylethyl)benzamide (R 1 =CH 2 Br, R 2 =H) (3) 
     To 3-(bromomethyl)benzoyl chloride (1) (1 g, 4.29 mmol) in DCM (100 mL) was added 2-amino-1-phenylethan-1-one (2) (737 mg, 4.29 mmol) and added NaHCO 3  (50 mL). The reaction mixture was stirred at room temperature for 1 hr. The stirred mixture was extracted with DCM, washed with brine, and then dried over anhydrous Na 2 SO 4 . Purification using an EA/HEX system column afforded 3-(bromomethyl)-N-(2-oxo-2-phenylethyl)benzamide (R 1 =CH 2 Br, R 2 =H) (3) (883 mg, 62%). 
       1 H-NMR (400 MHz, CDCl 3 ) δ 8.03-8.05 (m, 2H), 7.86-7.88 (m, 2H), 7.65 (d, J=7.3 Hz, 1H), 7.49-7.56 (m, 4H), 7.30 (s, 1H), 4.97 (d, J=4.1 Hz, 2H), 4.52 (s, 2H). 
     Preparation Method for 4-(bromomethyl)-N-(2-oxo-2-phenylethyl)benzamide (R 1 =CH 2 Br, R 2 =H) (3) 
     To 4-(bromomethyl)benzoyl chloride (1) (1 g, 4.29 mmol) in DCM (100 mL) was added 2-amino-1-phenylethan-1-one (2) (736 mg, 4.29 mmol) and added NaHCO 3  (50 mL). The reaction mixture was stirred at room temperature for 1 hr. The stirred mixture was extracted with DCM, washed brine and then dried over anhydrous Na 2 SO 4 . Purification using an EA/HEX system column afforded 4-(bromomethyl)-N-(2-oxo-2-phenylethyl)benzamide (R 1 =CH 2 Br, R 2 =H) (3) (1.18 g, 3.56 mmol, 83%). 
       1 H-NMR (400 MHz, CDCl 3 ) δ 8.05 (dd, J=8.5, 1.1 Hz, 2H), 7.91-7.92 (m, 1H), 7.81 (dd, J=6.2, 1.6 Hz, 1H), 7.64-7.68 (m, 1H), 7.52-7.59 (m, 3H), 7.47 (t, J=7.8 Hz, 1H), 7.31 (s, 1H), 4.98 (d, J=4.1 Hz, 2H), 4.55 (s, 2H) 
     Preparation Method for 3-(bromomethyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (R 1 =CH 2 Br, R 2 =OCH 3 ) (3) 
     To 3-(bromomethyl)benzoyl chloride (1) (1 g, 4.29 mmol) in DCM (100 mL) was added 1-amino-3-(3-methoxyphenyl)propan-2-one (2) (736 mg, 4.29 mmol) and added NaHCO 3  (50 mL). The reaction mixture was stirred at room temperature for 1 hr. The stirred mixture was extracted with DCM, washed brine and then dried over anhydrous Na 2 SO 4 . Purification using an r EA/HEX system column afforded 3-(bromomethyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (R 1 =CH 2 Br, R 2 =OCH 3 ) (3) (1.01 g, 65%). 
       1 H-NMR (400 MHz, CDCl 3 ) δ 7.91-7.92 (m, 1H), 7.81 (dt, J=7.8, 1.4 Hz, 1H), 7.61-7.64 (m, 1H), 7.54-7.59 (m, 2H), 7.46 (q, J=8.1 Hz, 2H), 7.18-7.21 (m, 1H), 4.96 (d, J=4.1 Hz, 2H), 4.55 (s, 2H), 3.89 (s, 3H). 
     Preparation Method for 2-(bromomethyl)-N-(2-oxo-2-phenylethyl)benzamide (R 1 =CH 2 Br, R 2 =H) (3) 
     To 2-(bromomethyl)benzoyl chloride (1) (1 g, 4.29 mmol) in DCM (100 mL) was added 2-amino-1-phenylethan-1-one (2) (736 mg, 4.29 mmol) and added NaHCO 3  (50 mL). The reaction mixture was stirred at room temperature for 1 hr. The stirred mixture was extracted with DCM, washed brine and then dried over anhydrous Na 2 SO 4 . The resulting crude product was purified by column chromatography to obtain the title compound (3) (955 mg, 67%). 
       1 H-NMR (400 MHz, CDCl 3 ) δ 8.02-8.05 (m, 2H), 7.66 (tt, J=7.5, 1.4 Hz, 1H), 7.37-7.59 (m, 6H), 7.10 (s, 1H), 4.99 (d, J=4.6 Hz, 2H), 4.84 (s, 2H) 
     General Preparation Method for Compounds 231 to 253 (DKC1125i01 to 23) 
     The title compounds were prepared. Specifically, to 3-(bromomethyl)-N-(2-oxo-2-phenylethyl)benzamide (R 1 =CH 2 Br, R 2 =H) (3) (50 mg, 0.15 mmol) in DCM (1 mL) was added secondary amine described in Table 10 below. Then, DIEA (39 mg, 0.30 mmol) was added thereto. The reaction mixture was stirred at 35° C. for 3 hrs. Purification using an EA/HEX system column afforded the final compound (yield: 50 to 60%). 
     
       
         
           
               
             
               
                 TABLE 10 
               
             
            
               
                   
               
               
                 Secondary amines used in preparation  
               
               
                 of compounds 231 to 253 
               
               
                 (DKC1125i01 to 23) 
               
            
           
           
               
               
               
            
               
                   
                 Compounds 
                 Secondary amine 
               
               
                   
                   
               
               
                   
                 DKC1125i01 
                 Dimethylamine hydrochloride 
               
               
                   
                 DKC1125i02 
                 1,2,3,4-tetrahydroisoquinoline 
               
               
                   
                 DKC1125i03 
                 N-methylisopropylamine 
               
               
                   
                 DKC1125i04 
                 1-(2-fluorophenyl)piperazine 
               
               
                   
                 DKC1125i05 
                 2-(1-Piperazinyl)pyrimidine 
               
               
                   
                 DKC1125i06 
                 1-(2-methoxyphenyl)piperazine 
               
               
                   
                 DKC1125i07 
                 4-Piperidinopiperidine 
               
               
                   
                 DKC1125i08 
                 1-(4-nitrophenyl)piperazine 
               
               
                   
                 DKC1125i09 
                 N-Ethylaniline 
               
               
                   
                 DKC1125i10 
                 1-(2-pyridyl)piperazine, HCl 
               
               
                   
                 DKC1125i11 
                 Diallylamine 
               
               
                   
                 DKC1125i12 
                 N-Benzylmethylamine 
               
               
                   
                 DKC1125i13 
                 2-(Methylamino)ethanol 
               
               
                   
                 DKC1125i14 
                 2-(Butylamino)ethanol 
               
               
                   
                 DKC1125i15 
                 1-Boc-piperazine 
               
               
                   
                 DKC1125i16 
                 N-methyl-1-butylamine 
               
               
                   
                 DKC1125i17 
                 Diethylamine 
               
               
                   
                 DKC1125i18 
                 Di-n-propylamine 
               
               
                   
                 DKC1125i19 
                 N-ethylbutylamine 
               
               
                   
                 DKC1125i20 
                 Dipentylamine 
               
               
                   
                 DKC1125i21 
                 N-Methylpropargylamine 
               
               
                   
                 DKC1125i22 
                 Morpholine 
               
               
                   
                 DKC1125i23 
                 1-methylpiperazine 
               
               
                   
                   
               
            
           
         
       
     
     General Preparation Method for Compounds 254 to 278 (DKC1125i24 to 48) 
     To 4-(bromomethyl)-N-(2-oxo-2-phenylethyl)benzamide (R 1 =CH 2 Br, R 2 =H) (3) (50 mg, 0.15 mmol) in DCM (1 mL) was added secondary amine shown in Table 11 below. Then, DIEA (39 mg, 0.30 mmol) was added thereto. The reaction mixture was stirred at 35° C. for 3 hrs. Purification using an EA/HEX system column afforded to the final compound (50 to 60% yield). 
     
       
         
           
               
             
               
                 TABLE 11 
               
             
            
               
                   
               
               
                 Secondary amines used in preparation 
               
               
                 of compounds 254 to 278 
               
               
                 (DKC1125i24 to 48) 
               
            
           
           
               
               
               
            
               
                   
                 Compounds 
                 Secondary amine 
               
               
                   
                   
               
               
                   
                 DKC1125i24 
                 1,2,3,4-tetrahydroisoquinoline 
               
               
                   
                 DKC1125i25 
                 N-methylcyclohexylamine 
               
               
                   
                 DKC1125i26 
                 N-methylisopropylamine 
               
               
                   
                 DKC1125i27 
                 1-(2-fluorophenyl)piperazine 
               
               
                   
                 DKC1125i28 
                 2-(1-Piperazinyl)pyrimidine 
               
               
                   
                 DKC1125i29 
                 1-(2-methoxyphenyl)piperazine 
               
               
                   
                 DKC1125i30 
                 4-Piperidinopiperidine 
               
               
                   
                 DKC1125i31 
                 1-(4-nitrophenyl)piperazine 
               
               
                   
                 DKC1125i32 
                 N-Methylaniline 
               
               
                   
                 DKC1125i33 
                 N-Ethylaniline 
               
               
                   
                 DKC1125i34 
                 1-(2-pyridyl)piperazine, HCl 
               
               
                   
                 DKC1125i35 
                 Diallylamine 
               
               
                   
                 DKC1125i36 
                 N-Benzylmethylamine 
               
               
                   
                 DKC1125i37 
                 2-(Methylamino)ethanol 
               
               
                   
                 DKC1125i38 
                 2-(Butylamino)ethanol 
               
               
                   
                 DKC1125i39 
                 1-Boc-piperazine 
               
               
                   
                 DKC1125i40 
                 dicyclohexylamine 
               
               
                   
                 DKC1125i41 
                 N-methyl-1-butylamine 
               
               
                   
                 DKC1125i42 
                 Di-n-propylamine 
               
               
                   
                 DKC1125i43 
                 N-ethylbutylamine 
               
               
                   
                 DKC1125i44 
                 2-(Ethylamino)ethanol 
               
               
                   
                 DKC1125i45 
                 N-Methylpropargylamine 
               
               
                   
                 DKC1125i46 
                 N-ethylpropan-1-amine 
               
               
                   
                 DKC1125i47 
                 Ethyl piperazine-1-carboxylate 
               
               
                   
                 DKC1125i48 
                 2,6-dimethylmorpholine 
               
               
                   
                   
               
            
           
         
       
     
     General Preparation Method for Compounds 279 to 295 (DKC1125i49 to 65) 
     To 3-(bromomethyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (R 1 =CH 2 Br, R 2 =OCH 3 ) (3) (50 mg, 0.15 mmol) in DCM (1 mL) was added secondary amine shown in Table 12 below. Then, DIEA (39 mg, 0.30 mmol) was added thereto. The reaction mixture was stirred at 35° C. for 3 hrs. Purification using an EA/HEX system column afforded the final compound (50 to 60% yield). 
     
       
         
           
               
             
               
                 TABLE 12 
               
             
            
               
                   
               
               
                 Secondary amines used in preparation 
               
               
                 of compounds 279 to 295  
               
               
                 (DKC1125i49 to 65) 
               
            
           
           
               
               
               
            
               
                   
                 Compounds 
                 Secondary amine 
               
               
                   
                   
               
               
                   
                 DKC1125i49 
                 1,2,3,4-tetrahydroisoquinoline 
               
               
                   
                 DKC1125i50 
                 N-methylcyclohexylamine 
               
               
                   
                 DKC1125i51 
                 1-(2-fluorophenyl)piperazine 
               
               
                   
                 DKC1125i52 
                 1-(2-methoxyphenyl)piperazine 
               
               
                   
                 DKC1125i53 
                 4-Piperidinopiperidine 
               
               
                   
                 DKC1125i54 
                 1-(2-pyridyl)piperazine, HCl 
               
               
                   
                 DKC1125i55 
                 Diallylamine 
               
               
                   
                 DKC1125i56 
                 N-Benzylmethylamine 
               
               
                   
                 DKC1125i57 
                 N-Ethylmethylamine 
               
               
                   
                 DKC1125i58 
                 2-(Butylamino)ethanol 
               
               
                   
                 DKC1125i59 
                 1-Boc-piperazine 
               
               
                   
                 DKC1125i60 
                 N-ethylbutylamine 
               
               
                   
                 DKC1125i61 
                 Dipentylamine 
               
               
                   
                 DKC1125i62 
                 1-Piperazineethanol 
               
               
                   
                 DKC1125i63 
                 morpholine 
               
               
                   
                 DKC1125i64 
                 N-ethylpropan-1-amine 
               
               
                   
                 DKC1125i65 
                 2,6-dimethylmorpholine 
               
               
                   
                   
               
            
           
         
       
     
     General Preparation Method for Compounds 296 to 305 (DKC1125i66 to 75) 
     To 2-(bromomethyl)-N-(2-oxo-2-phenylethyl)benzamide (R 1 =CH 2 Br, R 2 =H) (3) (50 mg, 0.15 mmol) in DCM (1 mL) was added secondary amine shown in Table 13 below. Then, DIEA (39 mg, 0.30 mmol) was added thereto. The reaction mixture was stirred at 35° C. for 3 hrs. Purification using an EA/HEX system column afforded the final compound (50 to 60% yield). 
     
       
         
           
               
             
               
                 TABLE 13 
               
             
            
               
                   
               
               
                 Secondary amines used in preparation  
               
               
                 of compounds 296 to 305 
               
               
                 (DKC1125i66 to 75) 
               
            
           
           
               
               
               
            
               
                   
                 Compounds 
                 Secondary amine 
               
               
                   
                   
               
               
                   
                 DKC1125i66 
                 Dimethylamine hydrochloride 
               
               
                   
                 DKC1125i67 
                 1,2,3,4-tetrahydroisoquinoline 
               
               
                   
                 DKC1125i68 
                 N-methylcyclohexylamine 
               
               
                   
                 DKC1125i69 
                 1-(2-fluorophenyl)piperazine 
               
               
                   
                 DKC1125i70 
                 2-(1-Piperazinyl)pyrimidine 
               
               
                   
                 DKC1125i71 
                 4-Piperidinopiperidine 
               
               
                   
                 DKC1125i72 
                 1-(2-pyridyl)piperazine, HCl 
               
               
                   
                 DKC1125i73 
                 Diallylamine 
               
               
                   
                 DKC1125i74 
                 Morpholine 
               
               
                   
                 DKC1125i75 
                 Ethyl piperazine-1-carboxylate 
               
               
                   
                   
               
            
           
         
       
     
     Confirmation of Preparation of Compounds 231 to 305 (DKC1125i01 to 75) 
     3-((dimethylamino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i01)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.02-7.29 (m, 10H), 4.94 (d, J=4.0 Hz, 2H), 3.62 (s, 2H), 2.34 (s, 6H). MS(ESI): m/z 297 (M+1). 
     3-((3,4-dihydroisoquinolin-2 (1H)-yl)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i02)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.01-7.44 (m, 10H), 7.10 (s, 3H), 6.97 (d, 8.0 Hz, 1H), 4.96 (d, J=4 Hz 2H), 3.75 (s, 2H), 3.65 (s, 2H), 2.79 (t, J=6.0 Hz, 2H), 1.26 (t, J=6.8 Hz, 2H). MS(ESI): m/z 385 (M+1). 
     3-((isopropyl(methyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i03)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.03-7.40 (m, 10H), 4.95 (d, J=4.0 Hz, 2H), 3.69 (s, 2H), 3.05 (q, J=6.4 Hz, 1H), 2.24 (s, 3H), 1.16 (d, J=6.4 Hz, 6H). MS(ESI): m/z 325 (M+1). 
     3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i04)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.04-8.06 (m, 2H), 7.89 (s, 1H), 7.79 (d, J=7.8 Hz, 1H), 7.66 (t, J=7.5 Hz, 1H), 7.52-7.56 (m, 3H), 7.44 (t, J=7.8 Hz, 1H), 7.33 (s, 1H), 6.90-7.07 (m, 4H), 4.98 (d, J=4.6 Hz, 2H), 3.65 (s, 2H), 3.13 (t, J=4.6 Hz, 4H), 2.67 (t, J=4.3 Hz, 4H). MS(ESI): m/z 432 (M+1). 
     N-(2-oxo-2-phenylethyl)-3-((4-(pyrimidin-2-yl)piperazin-1-yl)methyl)benzamide (DKC1125i05)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.27 (d, J=4.8 Hz, 2H), 8.02-7.39 (m, 10H), 6.45 (t, J=4.8 Hz, 1H), 4.95 (d, J=4.4 Hz, 2H), 3.83 (t, J=4.8 Hz, 4H), 3.60 (s, 2H), 2.52 (t, J=4.8 Hz, 4H). MS (ESI): m/z 417 (M+1). 
     3-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i06)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.09-7.33 (m, 10H), 7.01-6.84 (m, 4H), 4.98 (d, J=4.0 Hz, 2H), 3.85 (s, 3H), 3.65 (s, 2H), 3.10 (s, 4H), 2.68 (s, 4H). MS(ESI): m/z 445 (M+1). 
     3-([1,4′-bipiperidin]-1′-ylmethyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i07)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.01 (d, J=8.7 Hz, 2H), 7.80 (s, 1H), 7.76 (d, J=7.3 Hz, 1H), 7.63 (dd, J=8.0, 6.6 Hz, 1H), 7.49-7.53 (m, 2H), 7.34-7.45 (m, 3H), 4.94 (d, J=4.1 Hz, 2H), 3.52 (s, 2H), 2.95-3.10 (m, 6H), 2.01-2.13 (m, 5H), 1.75-1.84 (m, 2H), 1.44-1.58 (m, 4H), 1.16-1.30 (m, 2H). MS(ESI): m/z 421 (M+1). 
     3-((4-(4-nitrophenyl)piperazin-1-yl)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i08)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.02-8.14 (m, 4H), 7.88 (s, 1H), 7.79 (d, J=7.8 Hz, 1H), 7.63-7.67 (m, 1H), 7.51-7.54 (m, 3H), 7.41-7.46 (m, 1H), 7.34 (s, 1H), 6.79 (d, J=9.6 Hz, 2H), 4.97 (d, J=4.1 Hz, 2H), 3.62 (s, 2H), 3.42 (t, J=5.0 Hz, 4H), 2.60 (t, J=5.0 Hz, 4H). MS(ESI): m/z 460 (M+1). 
     3-((ethyl(phenyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i09)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.01-8.04 (m, 5H), 7.50-7.81 (m, 7H), 6.69 (s, 3H), 4.94 (d, J=4.1 Hz, 2H), 4.53 (s, 2H), 3.49 (brs, 2H), 1.67 (brs, 3H). MS(ESI): m/z 373 (M+1). 
     N-(2-oxo-2-phenylethyl)-3-((4-(pyridin-2-yl)piperazin-1-yl)methyl)benzamide (DKC1125i10)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.98-8.17 (m, 4H), 7.82 (d, J=7.8 Hz, 1H), 7.43-7.65 (m, 7H), 6.61-6.67 (m, 2H), 4.95 (d, J=4.4 Hz, 2H), 3.75 (s, 2H), 3.67 (t, J=4.8 Hz, 4H), 2.70 (brs, 4H). MS (ESI): m/z 416 (M+1). 
     3-((diallylamino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i11)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.03-8.06 (m, 2H), 7.30-7.84 (m, 8H), 5.85-5.95 (m, 2H), 5.15-5.24 (m, 4H), 4.97 (d, J=4.1 Hz, 2H), 3.64 (s, 2H), 3.10 (d, J=6.4 Hz, 4H). MS(ESI): m/z 349 (M+1). 
     3-((benzyl(methyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i12)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.04-8.07 (m, 2H), 7.88 (s, 1H), 7.27-7.78 (m, 12H), 4.98 (d, J=4.1 Hz, 2H), 3.59 (s, 2H), 3.55 (s, 2H), 2.20 (s, 3H). MS(ESI): m/z 373 (M+1). 
     3-(((2-hydroxyethyl) (methyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i13)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.03 (dd, J=8.5, 1.1 Hz, 2H), 7.92 (s, 1H), 7.79-7.82 (m, 1H), 7.62-7.64 (m, 1H), 7.42-7.54 (m, 5H), 4.95 (d, J=4.1 Hz, 2H), 3.76 (s, 2H), 3.71 (t, J=5.2 Hz, 2H), 3.13 (q, J=7.3 Hz, 1H), 2.72 (t, J=5.3 Hz, 2H), 2.35 (s, 3H). MS(ESI): m/z 327 (M+1). 
     3-((butyl (2-hydroxyethyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i14)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.16 (s, 1H), 8.00-8.02 (m, 2H), 7.88 (d, J=7.8 Hz, 1H), 7.61-7.69 (m, 3H), 7.45-7.53 (m, 3H), 4.94 (d, J=4.6 Hz, 2H), 4.11 (s, 2H), 3.83 (t, J=5.0 Hz, 2H), 3.13 (q, J=7.5 Hz, 2H), 3.00 (t, J=4.8 Hz, 2H), 2.86 (t, J=7.8 Hz, 2H), 1.58 (t, J=7.3 Hz, 2H), 0.90 (t, J=7.5 Hz, 3H). MS (ESI): m/z 369 (M+1). 
     tert-butyl 4-(3-((2-oxo-2-phenylethyl) carbamoyl)benzyl) piperazine-1-carboxylate (DKC1125i15)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.02-8.04 (m, 2H), 7.84 (s, 1H), 7.77 (d, J=7.8 Hz, 1H), 7.65 (t, J=7.5 Hz, 1H), 7.40-7.55 (m, 4H), 7.32 (s, 1H), 4.97 (d, J=4.1 Hz, 2H), 3.56 (s, 2H), 3.43 (t, J=4.8 Hz, 4H), 2.40 (brt, 4H), 1.45 (s, 9H). MS(ESI): m/z 439 (M+1). 
     3-((butyl (methyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i16)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.17 (s, 1H), 7.99-8.04 (m, 3H), 7.90 (d, J=7.8 Hz, 1H), 7.60-7.69 (m, 2H), 7.47-7.52 (m, 3H), 4.92 (d, J=5.0 Hz, 2H), 4.03 (s, 2H), 2.81 (t, J=8.0 Hz, 2H), 2.54 (s, 3H), 1.73-1.77 (m, 2H), 1.48-1.58 (m, 2H), 1.32-1.40 (m, 3H) MS(ESI): m/z 339 (M+1). 
     3-((diethylamino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i17)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.32 (s, 1H), 7.98-8.00 (m, 2H), 7.92 (d, J=7.8 Hz, 1H), 7.84 (s, 1H), 7.71 (d, J=7.8 Hz, 1H), 7.59-7.63 (m, 1H), 7.46-7.51 (m, 3H), 4.91 (d, J=4.6 Hz, 2H), 4.12 (s, 2H), 3.02 (q, J=7.3 Hz, 4H), 1.35 (t, J=7.1 Hz, 6H). MS(ESI): m/z 325 (M+1). 
     3-((dipropylamino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i18)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.04 (d, J=7.3 Hz, 2H), 7.84 (s, 1H), 7.75 (d, J=7.8 Hz, 1H), 7.64 (t, J=7.3 Hz, 1H), 7.33-7.54 (m, 5H), 4.96 (d, J=4.6 Hz, 2H), 3.62 (s, 2H), 2.35-2.41 (m, 4H), 1.45-1.54 (m, 4H), 0.87 (t, J=7.3 Hz, 6H). MS(ESI): m/z 353 (M+1). 
     3-((butyl(ethyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i19)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.37-8.18 (m, 10H), 4.94 (d, J=4.1 Hz, 2H), 3.96 (s, 2H), 2.75-3.05 (m, 4H), 1.25-1.84 (m, 10H). MS(ESI): m/z 353 (M+1). 
     3-((dipentylamino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i20)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.31-8.05 (m, 10H), 4.97 (d, J=4.1 Hz, 2H), 3.50-3.63 (m, 2H), 2.09-2.40 (m, 8H), 1.01-1.57 (m, 14H). MS(ESI): m/z 410 (M+1). 
     3-((ethynyl(methyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i21)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.04 (d, J=7.3 Hz, 2H), 7.79-7.85 (m, 2H), 7.63-7.67 (m, 1H), 7.32-7.55 (m, 5H), 4.97 (d, J=4.1 Hz, 2H), 3.64 (s, 2H), 3.33 (d, J=2.3 Hz, 1H), 2.35 (s, 3H). MS(ESI): m/z 307 (M+1). 
     3-(morpholinomethyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i22)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.04 (d, J=7.3 Hz, 2H), 7.85 (s, 1H), 7.77 (d, J=7.3 Hz, 1H), 7.62-7.67 (m, 1H), 7.33-7.55 (m, 5H), 4.96 (d, J=4.6 Hz, 2H), 3.71 (t, J=4.6 Hz, 4H), 3.56 (s, 2H), 2.46 (t, J=4.3 Hz, 4H). MS (ESI): m/z 339 (M+1). 
     3-((4-methylpiperazin-1-yl)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i23)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.34-8.04 (m, 10H), 4.96 (d, J=4.1 Hz, 2H), 3.56 (s, 2H), 2.52 (s, 11H). MS(ESI): m/z 352 (M+1). 
     4-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i24)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.03-8.08 (m, 2H), 7.86 (d, J=8.2 Hz, 2H), 7.63-7.67 (m, 1H), 7.50-7.55 (m, 4H), 7.31 (brs, 1H), 7.08-7.13 (m, 3H), 6.98-7.00 (m, 1H), 4.97 (d, J=4.1 Hz, 2H), 3.75 (s, 2H), 3.65 (s, 2H), 2.92 (t, J=5.7 Hz, 2H), 2.76 (t, J=5.9 Hz, 2H). MS(ESI): m/z 385 (M+1). 
     4-((cyclohexyl(methyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i25)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.08 (d, J=7.3 Hz, 2H), 7.92 (d, J=7.8 Hz, 2H), 7.55-7.71 (m, 5H), 7.38 (s, 1H), 5.01 (d, J=4.6 Hz, 2H), 3.91 (s, 2H), 3.72-3.79 (m, 1H), 2.43 (s, 3H), 2.09 (d, J=11.4 Hz, 2H), 1.89 (d, J=12.8 Hz, 2H), 1.61-1.72 (m, 2H), 1.43 (dd, J=12.1, 2.5 Hz, 2H), 1.21-1.33 (m, 2H). MS(ESI): m/z 365 (M+1). 
     4-((isopropyl(methyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i26)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.02-8.04 (m, 2H), 7.85-7.87 (m, 2H), 7.63-7.66 (m, 1H), 7.48-7.54 (m, 4H), 7.29 (s, 1H), 4.95 (d, J=4.1 Hz, 2H), 4.50 (s, 2H), 1.60 (s, 3H), 1.24 (s, 6H), 0.81-0.88 (m, 1H). MS (ESI): m/z 325 (M+1). 
     4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i27)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.03-8.06 (m, 2H), 7.85-7.87 (m, 2H), 7.63-7.68 (m, 1H), 7.47-7.56 (m, 4H), 7.30 (t, J=4.1 Hz, 1H), 6.91-7.08 (m, 4H), 4.98 (d, J=4.6 Hz, 2H), 3.64 (s, 2H), 3.12 (t, J=4.8 Hz, 4H), 2.65 (t, J=4.8 Hz, 4H). MS (ESI): m/z 433 (M+1). 
     N-(2-oxo-2-phenylethyl)-4-((4-(pyrimidin-2-yl)piperazin-1-yl)methyl)benzamide (DKC1125i28)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.30 (d, J=4.6 Hz, 2H), 8.03-8.05 (m, 2H), 7.86 (d, J=8.2 Hz, 2H), 7.65 (tt, J=7.4, 1.4 Hz, 1H), 7.46-7.55 (m, 4H), 7.30 (t, J=3.9 Hz, 1H), 6.47 (t, J=4.6 Hz, 1H), 4.97 (d, J=4.6 Hz, 2H), 3.84 (t, J=5.0 Hz, 4H), 3.60 (s, 2H), 2.51 (t, J=5.0 Hz, 4H). MS(ESI): m/z 417 (M+1). 
     4-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i29)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.03-8.05 (m, 2H), 7.86 (d, J=8.2 Hz, 2H), 7.63-7.67 (m, 1H), 7.47-7.55 (m, 4H), 7.30 (t, J=4.1 Hz, 1H), 6.84-7.02 (m, 4H), 4.97 (d=4.1 Hz, 2H), 3.86 (s, 3H), 3.64 (s, 2H), 3.10 (brs, 4H), 2.67 (brs, 4H). MS(ESI): m/z 445 (M+1). 
     4-([1,4′-bipiperidin]-1′-ylmethyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i30)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.99-8.02 (m, 2H), 7.82 (d, J=8.2 Hz, 2H), 7.60-7.62 (m, 1H), 7.50 (t, J=7.8 Hz, 2H), 7.34-7.38 (m, 3H), 4.93 (d, J=4.1 Hz, 2H), 3.65-3.72 (m, 3H), 3.54 (s, 2H), 3.11 (q, J=7.5 Hz, 4H), 2.98 (d, J=12.3 Hz, 2H), 2.21 (d, J=11.9 Hz, 2H), 2.09 (t, J=11.2 Hz, 2H), 1.86 (dd, J=11.9, 3.7 Hz, 2H), 1.55 (t, J=7.5 Hz, 4H). MS(ESI): m/z 421 (M+1). 
     4-((4-(4-nitrophenyl)piperazin-1-yl)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i31)  1 H-NMR (400 MHz, CDCl 3 ) 8.10-8.14 (m, 2H), 8.03-8.06 (m, 2H), 7.87 (d, J=8.2 Hz, 2H), 7.64-7.68 (m, 1H), 7.43-7.56 (m, 4H), 7.29 (t, J=4.1 Hz, 1H), 6.80-6.84 (m, 2H), 4.98 (d, J=4.6 Hz, 2H), 3.63 (s, 2H), 3.44 (t, J=5.0 Hz, 4H), 2.61 (t, J=5.3 Hz, 4H). MS(ESI): m/z 460 (M+1). 
     4-((methyl (phenyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i32)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.04 (d, J=7.8 Hz, 2H), 7.82-7.87 (m, 2H), 7.51-7.67 (m, 3H), 7.33-7.40 (m, 2H), 7.22-7.24 (m, 1H), 6.73-6.91 (m, 5H), 4.96 (d, J=4.1 Hz, 2H), 4.59 (s, 2H), 3.05 (s, 3H). MS (ESI): m/z 359 (M+1). 
     4-((ethyl(phenyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i33)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.02-8.05 (m, 3H), 7.82-7.88 (m, 3H), 7.49-7.68 (m, 6H), 7.30-7.36 (m, 1H), 7.19 (dd, J=8.9, 7.1 Hz, 1H), 6.69 (t, J=8.0 Hz, 1H), 4.97 (d, J=4.1 Hz, 2H), 4.52 (s, 2H), 3.50 (q, J=7.0 Hz, 2H), 1.22 (t, J=7.1 Hz, 3H). MS(ESI): m/z 373 (M+1). 
     N-(2-oxo-2-phenylethyl)-4-((4-(pyridin-2-yl)piperazin-1-yl)methyl)benzamide (DKC1125i34)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.18-8.19 (m, 1H), 8.03-8.06 (m, 2H), 7.86 (d, J=8.2 Hz, 2H), 7.63-7.68 (m, 1H), 7.45-7.56 (m, 5H), 7.29 (s, 1H), 6.60-6.65 (m, 2H), 4.98 (d, J=4.1 Hz, 2H), 3.61 (s, 2H), 3.56 (t, J=5.0 Hz, 4H), 2.57 (t, J=5.0 Hz, 4H). MS (ESI): m/z 416 (M+1). 
     4-((diallylamino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i35)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.04 (d, J=8.2 Hz, 2H), 7.83 (d, J=8.2 Hz, 2H), 7.63-7.67 (m, 1H), 7.53 (t, J=7.5 Hz, 2H), 7.28-7.45 (m, 3H), 5.83-5.93 (m, 2H), 5.13-5.22 (m, 4H), 4.97 (d, J=4.1 Hz, 2H), 3.62 (s, 2H), 3.08 (d, J=6.4 Hz, 4H). MS(ESI): m/z 349 (M+1). 
     4-((benzyl(methyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i36)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.04 (d, J=7.3 Hz, 2H), 7.85 (d, J=8.2 Hz, 2H), 7.65 (t, J=7.5 Hz, 1H), 7.47-7.55 (m, 4H), 7.27-7.38 (m, 6H), 4.97 (d, J=4.1 Hz, 2H), 3.57 (s, 2H), 3.54 (s, 2H), 2.20 (s, 3H). MS(ESI): m/z 373 (M+1). 
     4-(((2-hydroxyethyl) (methyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i37)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.02 (d, J=7.3 Hz, 2H), 7.86 (d, J=8.2 Hz, 2H), 7.63 (t, J=7.3 Hz, 1H), 7.47-7.53 (m, 4H), 7.36 (s, 1H), 4.95 (d, J=4.6 Hz, 2H), 3.80 (s, 2H), 3.72 (t, J=5.9 Hz, 2H), 2.75 (t, J=5.3 Hz, 2H), 2.37 (s, 3H). MS(ESI): m/z 327 (M+1). 
     4-((butyl(2-hydroxyethyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i38)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.02-8.04 (m, 2H), 7.86 (d, J=8.2 Hz, 2H), 7.64 (t, J=7.5 Hz, 1H), 7.46-7.54 (m, 4H), 7.34 (d, J=3.7 Hz, 1H), 4.96 (d, J=4.1 Hz, 2H), 3.80 (s, 2H), 3.65 (t, J=5.0 Hz, 2H), 3.13 (q, J=7.5 Hz, 1H), 2.75 (t, J=5.3 Hz, 2H), 2.59 (t, J=7.5 Hz, 2H), 1.54-1.60 (m, 2H), 1.24-1.34 (m, 2H), 0.89 (q, J=7.3 Hz, 3H). MS(ESI): m/z 369 (M+1). 
     tert-butyl 4-(4-((2-oxo-2-phenylethyl)carbamoyl)benzyl) piperazine-1-carboxylate (DKC1125i39)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.03 (d, J=7.3 Hz, 2H), 7.83 (d, J=8.2 Hz, 2H), 7.41-7.66 (m, 5H), 7.30 (d, J=3.7 Hz, 1H), 4.96 (d, J=4.1 Hz, 2H), 3.55 (s, 2H), 3.43 (t, J=4.6 Hz, 4H), 2.38 (brs, 4H), 1.44 (s, 9H). MS(ESI): m/z 439 (M+1). 
     4-((dicyclohexylamino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i40)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.03-8.05 (m, 2H), 7.80 (d, J=8.2 Hz, 2H), 7.47-7.67 (m, 6H), 4.97 (d, J=4.6 Hz, 2H), 3.80 (s, 2H), 2.49-2.55 (m, 2H), 1.56-1.78 (m, 10H), 1.01-1.30 (m, 10H). MS(ESI): m/z 434 (M+1). 
     4-((butyl (methyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i41)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.98-8.00 (m, 2H), 7.85 (d, J=8.2 Hz, 2H), 7.47-7.62 (m, 5H), 7.40 (t, J=4.1 Hz, 1H), 4.92 (d, J=4.1 Hz, 2H), 3.80 (s, 2H), 2.58 (t, J=8.0 Hz, 2H), 2.36 (s, 3H), 1.58-1.64 (m, 2H), 1.26-1.33 (m, 2H), 0.88 (t, J=7.3 Hz, 3H). MS (ESI): m/z 339 (M+1). 
     4-((dipropylamino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i42)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.01-8.03 (m, 2H), 7.82-7.84 (m, 2H), 7.61-7.65 (m, 1H), 7.40-7.53 (m, 4H), 7.29-7.32 (m, 1H), 4.95 (d, J=4.6 Hz, 2H), 3.66 (s, 2H), 2.42 (t, J=7.5 Hz, 4H), 1.47-1.56 (m, 4H), 0.86 (t, J=7.3 Hz, 6H). MS(ESI): m/z 353 (M+1). 
     4-((butyl(ethyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i43)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.01-8.03 (m, 2H), 7.82-7.84 (m, 2H), 7.61-7.65 (m, 1H), 7.40-7.53 (m, 4H), 7.29-7.32 (m, 1H), 4.95 (d, J=4.6 Hz, 2H), 3.66 (s, 2H), 2.42 (t, J=7.5 Hz, 4H), 1.47-1.56 (m, 4H), 0.86 (t, J=7.3 Hz, 6H). MS(ESI): m/z 353 (M+1). 
     4-((ethyl(2-hydroxyethyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i44)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.03 (d, J=7.3 Hz, 2H), 7.81-7.84 (m, 2H), 7.64 (t, J=7.5 Hz, 1H), 7.28-7.54 (m, 5H), 4.96 (d, J=4.6 Hz, 2H), 3.47-3.61 (m, 4H), 2.08-2.43 (m, 4H), 1.43-1.48 (m, 3H) MS(ESI): m/z 341 (M+1). 
     4-((ethynyl(methyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i45)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.03 (d, J=7.8 Hz, 2H), 7.84 (d, J=8.2 Hz, 2H), 7.30-7.66 (m, 6H), 4.96 (d, J=4.1 Hz, 2H), 3.63 (s, 2H), 3.32 (s, 1H), 2.34 (s, 3H). MS(ESI): m/z 307 (M+1). 
     4-(morpholinomethyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i46)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.04 (d, J=7.3 Hz, 2H), 7.84 (d, J=8.2 Hz, 2H), 7.65 (t, J=7.3 Hz, 1H), 7.43-7.55 (m, 4H), 7.29 (s, 1H), 4.96 (d, J=4.1 Hz, 2H), 3.72 (t, J=4.8 Hz, 4H), 3.55 (s, 2H), 2.45 (t, J=4.6 Hz, 4H). MS(ESI): m/z 339 (M+1). 
     ethyl 4-(4-((2-oxo-2-phenylethyl)carbamoyl)benzyl)piperazine-1-carboxylate (DKC1125i47)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.01 (d, J=8.5 Hz, 2H), 7.81-7.83 (m, 2H), 7.60-7.64 (m, 1H), 7.48-7.52 (m, 2H), 7.31-7.42 (m, 3H), 4.94 (d, J=4.1 Hz, 2H), 4.08-4.17 (m, 4H), 3.46 (t, J=5.2 Hz, 4H), 2.38 (s, 4H), 1.23 (t, J=6.8 Hz, 3H). MS(ESI): m/z 410 (M+1). 
     4-((2,6-dimethylmorpholino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i48)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.03 (d, J=7.8 Hz, 2H), 7.84 (d, J=7.8 Hz, 2H), 7.63-7.66 (m, 1H), 7.29-7.54 (m, 5H), 4.96 (d, J=4.1 Hz, 2H), 3.66-3.72 (m, 2H), 3.52 (s, 2H), 2.66-2.69 (m, 2H), 1.74-1.79 (m, 2H), 1.13 (d, J=5.9 Hz, 6H). MS(ESI): m/z 367 (M+1). 
     3-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (DKC1125i49) 1 H-NMR (400 MHz, CDCl 3 ) δ 7.79-7.90 (m, 2H), 7.53-7.63 (m, 3H), 7.32-7.46 (m, 3H), 7.17-7.20 (m, 1H), 7.09-7.12 (m, 3H), 6.98 (d, J=7.8 Hz, 1H), 4.95 (d, J=4.1 Hz, 2H), 3.88 (d, J=3.2 Hz, 3H), 3.75 (s, 2H), 3.65 (s, 2H), 2.92 (t, J=5.7 Hz, 2H), 2.77 (t, J=5.9 Hz, 2H). MS(ESI): m/z 416 (M+1). 
     3-((cyclohexyl(methyl)amino)methyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (DKC1125i50) 1 H-NMR (400 MHz, CDCl 3 ) δ 7.97 (s, 1H), 7.78 (d, J=7.8 Hz, 1H), 7.37-7.59 (m, 6H), 7.13-7.16 (m, 1H), 4.91 (d, J=4.6 Hz, 2H), 3.84 (s, 3H), 3.75 (s, 2H), 2.61 (s, 1H), 2.28 (s, 3H), 1.99 (d, J=11.0 Hz, 2H), 1.82 (d, J=12.8 Hz, 2H), 1.63 (d, J=12.8 Hz, 2H), 1.19-1.36 (m, 4H). MS(ESI): m/z 396 (M+1). 
     3-((1-(2-fluorophenyl)piperidin-4-yl)methyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (DKC1125i51) 1 H-NMR (400 MHz, CDCl 3 ) δ 7.77-7.88 (m, 2H), 7.33-7.63 (m, 6H), 6.91-7.19 (m, 5H), 4.95 (d, J=4.1 Hz, 2H), 3.87 (s, 3H), 3.12 (t, J=4.8 Hz, 4H), 2.94 (s, 1H), 2.87 (s, 1H), 2.65 (t, J=4.8 Hz, 5H). MS(ESI): m/z 462 (M+1). 
     N-(2-(3-methoxyphenyl)-2-oxoethyl)-3-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)benzamide (DKC1125i52)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.88 (s, 1H), 7.77-7.80 (m, 1H), 7.61-7.63 (m, 1H), 7.54-7.56 (m, 2H), 7.41-7.45 (m, 2H), 7.33 (t, J=3.9 Hz, 1H), 7.17-7.20 (m, 1H), 6.88-7.01 (m, 3H), 6.85 (dd, J=8.0, 1.1 Hz, 1H), 4.95 (d, J=4.6 Hz, 2H), 3.88 (s, 3H), 3.85 (s, 3H), 3.65 (s, 2H), 3.10 (brs, 4H), 2.69 (brs, 4H). MS(ESI): m/z 475 (M+1). 
     3-([1,4′-bipiperidin]-1′-ylmethyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (DKC1125i53) 1 H-NMR (400 MHz, CDCl 3 ) δ 7.75-7.82 (m, 2H), 7.34-7.62 (m, 6H), 7.18 (d, J=8.2 Hz, 1H), 4.94 (d, J=4.1 Hz, 2H), 3.87 (s, 3H), 3.53 (s, 2H), 2.94 (d, J=10.1 Hz, 1H), 2.61 (s, 8H), 1.99 (t, J=11.7 Hz, 2H), 1.83 (d, J=11.0 Hz, 2H), 1.66 (s, 4H), 1.46 (s, 2H). MS(ESI): m/z 451 (M+1). 
     N-(2-(3-methoxyphenyl)-2-oxoethyl)-3-((4-(pyridin-2-yl)piperazin-1-yl)methyl)benzamide (DKC1125i54)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.17-8.20 (m, 1H), 7.87 (s, 1H), 7.78 (d, J=7.8 Hz, 1H), 7.61-7.63 (m, 1H), 7.41-7.55 (m, 5H), 7.33 (t, J=4.3 Hz, 1H), 7.18 (dd, J=8.0, 3.0 Hz, 1H), 6.59-6.64 (m, 2H), 4.95 (d, J=4.1 Hz, 2H), 3.87 (s, 3H), 3.61 (s, 2H), 3.55 (t, J=5.0 Hz, 4H), 2.57 (t, J=5.0 Hz, 4H). MS (ESI): m/z 446 (M+1). 
     3-((diallylamino)methyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (DKC1125i55)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.84 (s, 1H), 7.75 (d, J=7.8 Hz, 1H), 7.61-7.63 (m, 1H), 7.51-7.54 (m, 2H), 7.42 (q, J=7.9 Hz, 2H), 7.30 (d, J=4.6 Hz, 1H), 7.18 (dd, J=8.0, 3.0 Hz, 1H), 5.84-5.94 (m, 2H), 5.16-5.24 (m, 4H), 4.95 (d, J=4.6 Hz, 2H), 3.88 (s, 3H), 3.64 (s, 2H), 3.10 (d, J=6.4 Hz, 4H). MS(ESI): m/z 379 (M+1). 
     3-((benzyl (methyl)amino)methyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (DKC1125i56) 1 H-NMR (400 MHz, CDCl 3 ) δ 7.98 (s, 1H), 7.81 (d, J=7.8 Hz, 1H), 7.29-7.62 (m, 11H), 7.16-7.19 (m, 1H), 4.94 (d, J=4.6 Hz, 2H), 3.87 (s, 4H), 3.73 (s, 3H), 2.29 (s, 3H). MS(ESI): m/z 403 (M+1). 
     3-((ethyl (methyl)amino)methyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (DKC1125i57) 1 H-NMR (400 MHz, CDCl 3 ) δ 7.30-7.91 (m, 8H), 7.18-7.21 (m, 1H), 4.96 (d, J=4.1 Hz, 2H), 4.65 (s, 1H), 4.54 (s, 1H), 3.85-3.89 (m, 5H), 1.61 (s, 3H), 1.25 (s, 3H). MS(ESI): m/z 341 (M+1). 
     3-((butyl (2-hydroxyethyl)amino)methyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (DKC1125i58) 1 H-NMR (400 MHz, CDCl 3 ) δ 8.13 (s, 1H), 7.87 (d, J=7.8 Hz, 1H), 7.40-7.63 (m, 6H), 7.15-7.18 (m, 1H), 4.93 (d, J=4.6 Hz, 2H), 4.06 (s, 2H), 3.87 (s, 3H), 3.80 (t, J=5.0 Hz, 2H), 2.96 (t, J=4.8 Hz, 2H), 2.82 (t, J=8.0 Hz, 2H), 1.58 (t, J=7.5 Hz, 3H), 1.30-1.35 (m, 4H). MS (ESI): m/z 400 (M+1). 
     tert-butyl 4-(3-((2-(3-methoxyphenyl)-2-oxoethyl)carbamoyl)benzyl)piperazine-1-carboxylate (DKC1125i59)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.84 (s, 1H), 7.77 (dd, J=7.8, 1.4 Hz, 1H), 7.62 (dd, J=7.8, 0.9 Hz, 1H), 7.29-7.54 (m, 5H), 7.17-7.20 (m, 1H), 4.95 (d, J=4.1 Hz, 2H), 3.88 (s, 3H), 3.57 (s, 2H), 3.44 (t, J=4.6 Hz, 4H), 2.41 (brs, 4H), 1.45 (s, 9H). MS(ESI): m/z 469 (M+1). 
     3-((butyl (ethyl)amino)methyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (DKC1125i60)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.04 (s, 1H), 7.82 (d, J=7.8 Hz, 1H), 7.61 (d, J=7.8 Hz, 2H), 7.40-7.53 (m, 4H), 7.15-7.18 (m, 1H), 4.93 (d, J=4.6 Hz, 2H), 3.87 (s, 3H), 3.82 (s, 2H), 2.72 (q, J=7.0 Hz, 2H), 2.62 (t, J=7.8 Hz, 2H), 1.50 (d, J=6.9 Hz, 3H), 1.27-1.37 (m, 2H), 1.18 (t, J=7.1 Hz, 2H), 0.90 (t, J=7.3 Hz, 3H). MS(ESI): m/z 384 (M+1). 
     3-((dipentylamino)methyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (DKC1125i61)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.82 (s, 1H), 7.72-7.76 (m, 1H), 7.62 (d, J=7.8 Hz, 1H), 7.52-7.57 (m, 2H), 7.35-7.46 (m, 2H), 7.30 (d, J=3.2 Hz, 1H), 7.17-7.21 (m, 1H), 4.95 (d, J=4.1 Hz, 2H), 3.88 (s, 3H), 3.55 (s, 2H), 2.02-2.43 (m, 8H), 1.39-1.58 (m, 6H), 1.22-1.32 (m, 8H). MS(ESI): m/z 371 (M+1). 
     3-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (DKC1125i62) 1 H-NMR (400 MHz, CDCl 3 ) δ 7.88 (s, 1H), 7.78 (d, J=7.8 Hz, 1H), 7.69 (s, 1H), 7.60 (d, J=7.8 Hz, 1H), 7.34-7.52 (m, 4H), 7.16-7.19 (m, 1H), 4.93 (d, J=4.6 Hz, 2H), 3.88 (s, 3H), 3.66 (s, 2H), 3.12 (t, J=7.5 Hz, 2H), 2.95 (t, J=4.8 Hz, 2H), 2.83 (brs, 4H), 1.50 (brs, 4H). MS(ESI): m/z 440 (M+1). 
     N-(2-(3-methoxyphenyl)-2-oxoethyl)-3-(morpholinomethyl)benzamide (DKC1125i63)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.91 (s, 1H), 7.77 (d, J=7.8 Hz, 1H), 7.49-7.59 (m, 3H), 7.37-7.42 (m, 3H), 7.13-7.16 (m, 1H), 4.91 (d, J=4.1 Hz, 2H), 3.84 (s, 3H), 3.74 (t, J=4.6 Hz, 4H), 3.64 (s, 2H), 3.11 (q, J=7.3 Hz, 2H), 1.53 (q, J=7.0 Hz, 2H). MS (ESI): m/z 369 (M+1). 
     3-((ethyl(propyl)amino)methyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (DKC1125i64) 1 H-NMR (400 MHz, CDCl 3 ) δ 8.15 (s, 1H), 7.76-7.79 (m, 1H), 7.48-7.66 (m, 3H), 7.33-7.42 (m, 3H), 7.14-7.18 (m, 1H), 4.90 (d, J=5.0 Hz, 2H), 3.99 (s, 2H), 3.85 (s, 3H), 3.61-3.70 (m, 2H), 1.47 (d, J=6.9 Hz, 2H), 0.94-0.99 (m, 8H). MS(ESI): m/z 369 (M+1). 
     3-((2,6-dimethylmorpholino)methyl)-N-(2-(3-methoxyphenyl)-2-oxoethyl)benzamide (DKC1125i65) 1 H-NMR (400 MHz, CDCl 3 ) δ 7.84 (s, 1H), 7.77 (d, J=7.8 Hz, 1H), 7.62 (d, J=7.8 Hz, 1H), 7.50-7.54 (m, 2H), 7.43 (td, J=7.8, 4.1 Hz, 2H), 7.30 (d, J=4.1 Hz, 1H), 7.17-7.20 (m, 1H), 4.95 (d, J=4.1 Hz, 2H), 3.88 (s, 3H), 3.67-3.73 (m, 2H), 3.53 (s, 2H), 2.67 (t, J=10.6 Hz, 2H), 1.78 (t, J=10.7 Hz, 2H), 1.14 (d, J=6.4 Hz, 6H). MS(ESI): m/z 397 (M+1). 
     2-((dimethylamino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i66)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.42-8.05 (m, 10H), 3.67 (d, J=4.1 Hz, 2H), 3.10 (s, 2H), 1.47 (s, 6H). MS(ESI): m/z 297 (M+1). 
     2-((3,4-dihydroquinolin-1(2H)-yl)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i67)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.93-8.08 (m, 4H), 7.38-7.60 (m, 8H), 7.04-7.10 (m, 1H), 6.92 (d, J=6.9 Hz, 1H), 4.85 (d, J=3.7 Hz, 2H), 3.93 (s, 2H), 2.97-3.09 (m, 2H), 2.90 (t, J=5.7 Hz, 2H), 2.83 (t, J=5.7 Hz, 2H). MS(ESI): m/z 385 (M+1). 
     2-((cyclohexyl(methyl)amino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i68)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.97-8.01 (m, 3H), 7.83 (d, J=7.3 Hz, 1H), 7.47-7.65 (m, 6H), 4.92 (s, 2H), 4.35 (s, 2H), 3.66-3.72 (m, 1H), 2.63 (s, 3H), 2.23 (d, J=11.0 Hz, 2H), 1.89 (d, J=13.3 Hz, 2H), 1.67 (d, J=13.3 Hz, 2H), 1.28 (m, 4H). MS(ESI): m/z 365 (M+1). 
     2-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i69)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.99-8.07 (m, 3H), 7.42-7.66 (m, 7H), 7.00-7.10 (m, 2H), 6.91-6.97 (m, 2H), 5.02 (d, J=5.5 Hz, 2H), 3.81 (s, 2H), 3.12 (brs, 4H), 2.76 (brs, 4H). MS(ESI): m/z 433 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-((4-(pyrimidin-2-yl)piperazin-1-yl)methyl)benzamide (DKC1125i70)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.28 (d, J=4.4 Hz, 2H), 7.96-8.03 (m, 3H), 7.41-7.63 (m, 6H), 7.20 (d, J=6.8 Hz, 1H), 6.48 (t, J=4.4 Hz, 1H), 5.02 (d, J=5.0 Hz, 2H), 3.84 (brs, 4H), 3.74 (s, 2H), 2.60 (t, J=5.0 Hz, 4H). MS(ESI): m/z 417 (M+1). 
     2-([1,4′-bipiperidin]-1′-ylmethyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i71)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.89-7.99 (m, 3H), 7.37-7.64 (m, 5H), 7.20 (d, J=5.9 Hz, 1H), 5.06 (d, J=4.6 Hz, 2H), 3.66-3.73 (m, 3H), 3.06-3.15 (m, 4H), 2.02-2.25 (m, 4H), 1.49-1.58 (m, 10H). MS(ESI): m/z 421 (M+1). 
     N-(2-oxo-2-phenylethyl)-2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)benzamide (DKC1125i72)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.16-8.17 (m, 1H), 7.97-8.03 (m, 3H), 7.59-7.63 (m, 1H), 7.39-7.54 (m, 6H), 7.22-7.24 (m, 1H), 6.60-6.67 (m, 2H), 5.00 (d, J=5.0 Hz, 2H), 3.77 (s, 2H), 3.54 (t, J=4.8 Hz, 4H), 2.66 (t, J=5.0 Hz, 4H). MS(ESI): m/z 415 (M+1). 
     2-((diallylamino)methyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i73)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.02-8.04 (m, 2H), 7.92-7.95 (m, 1H), 7.37-7.63 (m, 7H), 5.81-5.92 (m, 2H), 5.14-5.21 (m, 4H), 4.97 (s, 2H), 3.81 (s, 2H), 3.18 (d, J=6.9 Hz, 4H). MS(ESI): m/z 349 (M+1). 
     2-(morpholinomethyl)-N-(2-oxo-2-phenylethyl)benzamide (DKC1125i74)  1 H-NMR (400 MHz, CDCl 3 ) δ 7.92-8.05 (m, 3H), 7.37-7.69 (m, 6H), 7.20-7.23 (m, 1H), 5.01 (d, J=5.0 Hz, 2H), 3.67-3.73 (m, 6H), 2.55 (brs, 4H). MS(ESI): m/z 339 (M+1). 
     ethyl 4-(2-((2-oxo-2-phenylethyl)carbamoyl)benzyl)piperazine-1-carboxylate (DKC1125i75)  1 H-NMR (400 MHz, CDCl 3 ) δ 8.01-8.03 (m, 2H), 7.91-7.96 (m, 1H), 7.60-7.64 (m, 1H), 7.37-7.55 (m, 6H), 7.19 (dd, J=6.9, 1.8 Hz, 1H), 5.01 (d, J=4.6 Hz, 2H), 4.12 (q, J=7.2 Hz, 2H), 3.70 (s, 2H), 3.50 (t, J=4.6 Hz, 4H), 2.50 (t, J=5.0 Hz, 4H), 1.24 (t, J=7.1 Hz, 3H). MS(ESI): m/z 410 (M+1). 
     Experimental Example 1: Measurement of Cancer Metastasis-Related Promoter Activity-Increasing Effects of Compounds by Luciferase Assay 
     Experiments were conducted to evaluate the metastasis-related promoter activity-increasing effects of the compounds according to the present invention. Specifically, the KAI1 promoter reporter vector was used. In this case, the pRL-TK vector, a vector expressing  renilla  luciferase, was used as an internal control indicating the transfection efficiency in each transfected well. 
     First, 24 hours before transfection, 2×10 6  human colon cancer cell line, Caco2) cells were cultured in 10 ml of DMEM containing 10% FBS and 1% penicillin/streptomycin on a 100-mm-diameter plate, and then transformed with 5 μg of a pRL-TK vector mixture containing a transfection reagent and the KAI1 promoter, and then cultured in a 5% CO 2  incubator at 37° C. for 48 hours. Thereafter, the adherent cells were detached using trypsin and counted using a hemacytometer, and then 5×10 3  transfected Caco2 cells in 100 μl of DMEM containing 10% FBS and 1% penicillin/streptomycin were seeded into each well of a 96-well plate and cultured in a 5% CO 2  incubator at 37° C. for 24 hours. Next, 1 μM of each of the 305 compounds prepared in Examples 1 to 305 was added to each well, and after 16 hours, 100 μl of a lysis buffer for analysis containing a luciferase substrate was added, and the cells were lysed with stirring for 20 minutes. After completion of lysis, the cells were measured for luciferase activity using a luciferase reporter assay system (Promega, USA). In the experiment, DMSO was used as a control, and PHA-665752 known to increase the KAI1 promoter activity was used as a negative control. In addition, data were analyzed at a significance level of p&lt;0.05 by one-way ANOVA (Tukey&#39;s HSD), and SPSS 17.0 (Chicago, USA) statistical program was used. The results are shown in Tables 14 to 20 below. In Table 14 to 20, PHA is the PHA-665752, and KIT is KITENIN. 
     As a result of the experiment, it was confirmed that compounds 1 to 305 of Examples 1 to 305 had more significant effects on the KAI1 promoter reporter activity than the control DMSO. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 14 
               
               
                   
               
               
                   
                 Relative 
                   
                   
               
               
                   
                 KAI 
                   
                 In vivo 
               
               
                   
                 promoter  
                   
                 relative 
               
               
                   
                 activity 
                 SD 
                 invation 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 cont 
                 1.00 
                 0.02 
                   
               
               
                 PHA 
                 1.43 
                 0.27 
                   
               
               
                 Example 1 (DKC1125a1) 
                 1.70 
                 0.12 
                 0.967212071 
               
               
                 Example 2 (DKC1125a2) 
                 1.14 
                 0.08 
                 0.865139296 
               
               
                 Example 3 (DKC1125a3) 
                 2.12 
                 0.13 
                 1.0000975 
               
               
                 Example 4 (DKC1125a4) 
                 1.88 
                 0.11 
                 1.083507938 
               
               
                 Example 5 (DKC1125a5) 
                 1.98 
                 0.14 
                 0.812007649 
               
               
                 Example 6 (DKC1125a6) 
                 1.91 
                 0.12 
                 1.143814805 
               
               
                 Example 7 (DKC1125a7) 
                 1.20 
                 0.08 
                 1.091112955 
               
               
                 Example 8 (DKC1125a8) 
                 1.15 
                 0.09 
                 1.0773117 
               
               
                 Example 9 (DKC1125a9) 
                 1.14 
                 0.09 
                 0.84188251 
               
               
                 Example 10 (DKC1125a10) 
                 1.08 
                 0.06 
                 0.909895874 
               
               
                 Example 11 (DKC1125a11) 
                 1.82 
                 0.12 
                 1.036035283 
               
               
                 Example 12 (DKC1125a12) 
                 1.75 
                 0.12 
                 1.357212927 
               
               
                 Example 13 (DKC1125a13) 
                 1.73 
                 0.14 
                 0.856537389 
               
               
                 Example 14 (DKC1125a14) 
                 1.02 
                 0.08 
                 0.91063011 
               
               
                 Example 15 (DKC1125a15) 
                 1.74 
                 0.16 
                 1.170012516 
               
               
                 Example 16 (DKC1125a16) 
                 0.92 
                 0.08 
                 0.964495994 
               
               
                 Example 17 (DKC1125a17) 
                 0.98 
                 0.03 
                 0.928830813 
               
               
                 Example 18 (DKC1125a18) 
                 2.18 
                 0.06 
                 1.099903893 
               
               
                 Example 19 (DKC1125a19) 
                 0.98 
                 0.06 
                 1.201337942 
               
               
                 Example 20 (DKC1125a20) 
                 0.99 
                 0.05 
                 1.217248385 
               
               
                 Example 21 (DKC1125a21) 
                 0.99 
                 0.11 
                 1.098839349 
               
               
                 Example 22 (DKC1125a22) 
                 1.56 
                 0.07 
                 1.16319745 
               
               
                 Example 23 (DKC1125a23) 
                 1.00 
                 0.05 
                 1.103863595 
               
               
                 Example 24 (DKC1125a24) 
                 0.84 
                 0.05 
                 1.127960077 
               
               
                 Example 25 (DKC1125a25) 
                 1.49 
                 0.06 
                 1.215411799 
               
               
                 Example 26 (DKC1125a26) 
                 1.26 
                 0.16 
                 1.062762281 
               
               
                 Example 27 (DKC1125a27) 
                 1.31 
                 0.13 
                 1.043524891 
               
               
                 Example 28 (DKC1125a28) 
                 1.02 
                 0.07 
                 1.057274411 
               
               
                 Example 29 (DKC1125a29) 
                 0.90 
                 0.03 
                 1.026118119 
               
               
                 Example 30 (DKC1125a30) 
                 1.41 
                 0.13 
                 0.763132184 
               
               
                 Example 31 (DKC1125a31) 
                 1.18 
                 0.11 
                 0.821148791 
               
               
                 Example 32 (DKC1125a32) 
                 1.02 
                 0.08 
                 1.383289259 
               
               
                 Example 33 (DKC1125a33) 
                 1.78 
                 0.12 
                 0.751253077 
               
               
                 Example 34 (DKC1125a34) 
                 1.34 
                 0.13 
                 1.10271548 
               
               
                 Example 35 (DKC1125a35) 
                 1.28 
                 0.09 
                 0.881117392 
               
               
                 Example 36 (DKC1125a36) 
                 1.16 
                 0.08 
                 1.055670632 
               
               
                 Example 37 (DKC1125a37) 
                 1.17 
                 0.06 
                 0.964820331 
               
               
                 Example 38 (DKC1125a38) 
                 1.57 
                 0.18 
                 1.118590107 
               
               
                 Example 39 (DKC1125a39) 
                 1.21 
                 0.13 
                 0.598418507 
               
               
                 Example 40 (DKC1125a40) 
                 1.00 
                 0.03 
                 1.173484717 
               
               
                 Example 41 (DKC1125a41) 
                 1.19 
                 0.14 
                 0.756462374 
               
               
                 Example 42 (DKC1125a42) 
                 1.12 
                 0.07 
                 1.525309265 
               
               
                 Example 43 (DKC1125a43) 
                 1.91 
                 0.17 
                 0.977360052 
               
               
                 EV 
                   
                   
                 1 
               
               
                 KIT 
                   
                   
                 1.418701735 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                 TABLE 15 
               
               
                   
               
               
                   
                 Relative  
                   
                   
               
               
                   
                 KAI 
                   
                 In vivo 
               
               
                   
                 promoter  
                   
                 relative 
               
               
                   
                 activity 
                 SD 
                 invation 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 cont 
                 1.00 
                 0.02 
                   
               
               
                 PHA 
                 1.43 
                 0.27 
                   
               
               
                 Example 44 (DKC1125b1) 
                 0.98 
                 0.06 
                 0.975231046 
               
               
                 Example 45 (DKC1125b2) 
                 0.84 
                 0.03 
                 1.475976967 
               
               
                 Example 46 (DKC1125b3) 
                 0.98 
                 0.06 
                 1.181352768 
               
               
                 Example 47 (DKC1125b4) 
                 0.76 
                 0.02 
                 0.903801892 
               
               
                 Example 48 (DKC1125b5) 
                 0.85 
                 0.05 
                 1.189692419 
               
               
                 Example 49 (DKC1125b6) 
                 0.70 
                 0.06 
                 1.196722292 
               
               
                 Example 50 (DKC1125b7) 
                 0.94 
                 0.03 
                 1.089160084 
               
               
                 Example 51 (DKC1125b8) 
                 1.81 
                 0.07 
                 1.512528499 
               
               
                 Example 52 (DKC1125b9) 
                 1.36 
                 0.13 
                 1.157600115 
               
               
                 Example 53 (DKC1125b10) 
                 2.02 
                 0.12 
                 0.941084399 
               
               
                 Example 54 (DKC1125b11) 
                 0.70 
                 0.04 
                 1.082513363 
               
               
                 Example 55 (DKC1125b12) 
                 0.67 
                 0.02 
                 1.178638102 
               
               
                 Example 56 (DKC1125b13) 
                 0.92 
                 0.08 
                 1.248572694 
               
               
                 Example 57 (DKC1125b14) 
                 0.94 
                 0.08 
                 1.216616259 
               
               
                 Example 58 (DKC1125b15) 
                 0.91 
                 0.08 
                 1.243673251 
               
               
                 Example 59 (DKC1125b16) 
                 1.56 
                 0.04 
                 1.007369545 
               
               
                 Example 60 (DKC1125b17) 
                 0.81 
                 0.04 
                 0.9712691 
               
               
                 Example 61 (DKC1125b18) 
                 0.72 
                 0.03 
                 1.000434781 
               
               
                 Example 62 (DKC1125b19) 
                 1.03 
                 0.05 
                 1.122415428 
               
               
                 Example 63 (DKC1125b20) 
                 0.70 
                 0.02 
                 1.102301352 
               
               
                 Example 64 (DKC1125b21) 
                 1.35 
                 0.09 
                 1.083225317 
               
               
                 Example 65 (DKC1125b22) 
                 0.84 
                 0.03 
                 1.191339154 
               
               
                 Example 66 (DKC1125b23) 
                 0.87 
                 0.08 
                 1.167665305 
               
               
                 Example 67 (DKC1125b24) 
                 0.87 
                 0.07 
                 1.174738656 
               
               
                 Example 68 (DKC1125b25) 
                 0.88 
                 0.05 
                 1.124828465 
               
               
                 Example 69 (DKC1125b26) 
                 0.84 
                 0.04 
                 1.095461697 
               
               
                 Example 70 (DKC1125b27) 
                 0.81 
                 0.03 
                 1.273966647 
               
               
                 Example 71 (DKC1125b28) 
                 0.85 
                 0.06 
                 1.134844742 
               
               
                 Example 72 (DKC1125b29) 
                 0.80 
                 0.05 
                 1.04378249 
               
               
                 Example 73 (DKC1125b30) 
                 0.99 
                 0.06 
                 1.115749685 
               
               
                 Example 74 (DKC1125b31) 
                 0.78 
                 0.05 
                 1.169583778 
               
               
                 Example 75 (DKC1125b32) 
                 0.71 
                 0.07 
                 1.283061731 
               
               
                 Example 76 (DKC1125b33) 
                 0.83 
                 0.06 
                 1.120344782 
               
               
                 Example 77 (DKC1125b34) 
                 0.92 
                 0.05 
                 1.273648713 
               
               
                 Example 78 (DKC1125b35) 
                 0.90 
                 0.05 
                 1.170409863 
               
               
                 Example 79 (DKC1125b36) 
                 1.03 
                 0.05 
                 1.101727984 
               
               
                 Example 80 (DKC1125b37) 
                 0.86 
                 0.07 
                 1.182643525 
               
               
                 Example 81 (DKC1125b38) 
                 0.80 
                 0.04 
                 1.142382765 
               
               
                 Example 82 (DKC1125b39) 
                 0.80 
                 0.02 
                 1.189048399 
               
               
                 Example 83 (DKC1125b40) 
                 0.80 
                 0.05 
                 1.170551167 
               
               
                 Example 84 (DKC1125b41) 
                 0.94 
                 0.04 
                 1.181249507 
               
               
                 Example 85 (DKC1125b42) 
                 0.96 
                 0.07 
                 1.206282048 
               
               
                 Example 86 (DKC1125b43) 
                 1.01 
                 0.07 
                 1.192621759 
               
               
                 Example 87 (DKC1125b44) 
                 0.91 
                 0.07 
                 1.218137994 
               
               
                 EV 
                   
                   
                 1 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                 TABLE 16 
               
               
                   
               
               
                   
                 Relative 
                   
                   
               
               
                   
                 KAI 
                   
                 In vivo 
               
               
                   
                 promoter 
                   
                 relative 
               
               
                   
                 activity 
                 SD 
                 invation 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 con 
                 1 
                 0.055867817 
                   
               
               
                 PHA 
                 1.20 
                 0.043393675 
                   
               
               
                 Example 88 (DKC1125C1) 
                 1.35 
                 0.081249856 
                 0.921644707 
               
               
                 Example 89 (DKC1125C2) 
                 1.27 
                 0.059512199 
                 1.07388343 
               
               
                 Example 90 (DKC1125C3) 
                 1.88 
                 0.219588912 
                 1.124246315 
               
               
                 Example 91 (DKC1125C4) 
                 2.44 
                 0.221626597 
                 1.0580728 
               
               
                 Example 92 (DKC1125C5) 
                 2.29 
                 0.179681535 
                 1.064202769 
               
               
                 Example 93 (DKC1125C6) 
                 2.48 
                 0.140226867 
                 1.090545444 
               
               
                 Example 94 (DKC1125C7) 
                 1.81 
                 0.090850801 
                 1.095687249 
               
               
                 Example 95 (DKC1125C8) 
                 1.21 
                 0.046088014 
                 1.160261277 
               
               
                 Example 96 (DKC1125C9) 
                 2.23 
                 0.129624575 
                 1.140757593 
               
               
                 Example 97 (DKC1125C10) 
                 1.80 
                 0.087958979 
                 1.02382481 
               
               
                 Example 98 (DKC1125C11) 
                 2.64 
                 0.112880624 
                 1.120653752 
               
               
                 Example 99 (DKC1125C12) 
                 1.71 
                 0.049767964 
                 1.133689705 
               
               
                 Example 100 (DKC1125C13) 
                 1.62 
                 0.051742572 
                 1.093844908 
               
               
                 Example 101 (DKC1125C14) 
                 3.04 
                 0.146269026 
                 0.881467731 
               
               
                 Example 102 (DKC1125C15) 
                 2.53 
                 0.156923386 
                 1.120589549 
               
               
                 Example 103 (DKC1125C16) 
                 1.70 
                 0.050962298 
                 1.171655873 
               
               
                 Example 104 (DKC1125C17) 
                 1.78 
                 0.055249295 
                 1.115470076 
               
               
                 Example 105 (DKC1125C18) 
                 1.25 
                 0.039978414 
                 1.0791341 
               
               
                 Example 106 (DKC1125C19) 
                 2.44 
                 0.129482512 
                 1.170731912 
               
               
                 Example 107 (DKC1125C20) 
                 2.07 
                 0.147047337 
                 0.986796561 
               
               
                 Example 108 (DKC1125C21) 
                 1.36 
                 0.071134957 
                 0.989004578 
               
               
                 Example 109 (DKC1125C22) 
                 2.89 
                 0.287084408 
                 0.905353953 
               
               
                 Example 110 (DKC1125C23) 
                 1.49 
                 0.059141858 
                 1.009342899 
               
               
                 Example 111 (DKC1125C24) 
                 1.44 
                 0.058746042 
                 1.065364002 
               
               
                 Example 112 (DKC1125C25) 
                 2.82 
                 0.128566052 
                 0.983474766 
               
               
                 Example 113 (DKC1125C26) 
                 1.40 
                 0.044927755 
                 1.166980237 
               
               
                 Example 114 (DKC1125C27) 
                 1.38 
                 0.04051327 
                 1.196784279 
               
               
                 Example 115 (DKC1125C28) 
                 2.04 
                 0.133934593 
                 1.209331733 
               
               
                 Example 116 (DKC1125C29) 
                 2.15 
                 0.19730863 
                 1.164258598 
               
               
                 Example 117 (DKC1125C30) 
                 1.32 
                 0.062835904 
                 1.075661568 
               
               
                 Example 118 (DKC1125C31) 
                 1.74 
                 0.13810257 
                 0.76806331 
               
               
                 Example 119 (DKC1125C32) 
                 1.35 
                 0.041971277 
                 1.202847253 
               
               
                 Example 120 (DKC1125C33) 
                 1.38 
                 0.049104151 
                 1.096641916 
               
               
                 Example 121 (DKC1125C34) 
                 0.96 
                 0.186314456 
                 1.202604399 
               
               
                 EV 
                   
                   
                 1 
               
               
                 KIT 
                   
                   
                 1.156487271 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                 TABLE 17 
               
               
                   
               
               
                   
                 Relative 
                   
                   
               
               
                   
                 KAI 
                   
                 In vivo 
               
               
                   
                 promoter 
                   
                 relative 
               
               
                   
                 activity 
                 SD 
                 invation 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 Cont 
                 1.00 
                 0.04 
                   
               
               
                 PHA 
                 2.04 
                 0.50 
                   
               
               
                 Example 122 (DKC1125D1) 
                 1.65 
                 0.08 
                 1.373534212 
               
               
                 Example 123 (DKC1125D2) 
                 1.14 
                 0.02 
                 1.312034373 
               
               
                 Example 124 (DKC1125D3) 
                 1.04 
                 0.04 
                 1.266167671 
               
               
                 Example 125 (DKC1125D4) 
                 1.48 
                 0.07 
                 0.89653738 
               
               
                 Example 126 (DKC1125D5) 
                 1.08 
                 0.02 
                 1.351757201 
               
               
                 Example 127 (DKC1125D6) 
                 2.46 
                 0.07 
                 1.350506317 
               
               
                 Example 128 (DKC1125D7) 
                 1.10 
                 0.04 
                 1.179120716 
               
               
                 Example 129 (DKC1125D8) 
                 1.30 
                 0.04 
                 1.298274653 
               
               
                 Example 130 (DKC1125E1) 
                 1.32 
                 0.05 
                 0.987543526 
               
               
                 Example 131 (DKC1125E2) 
                 1.19 
                 0.05 
                 1.292834764 
               
               
                 Example 132 (DKC1125E3) 
                 1.18 
                 0.02 
                 1.226348845 
               
               
                 Example 133 (DKC1125E4) 
                 1.15 
                 0.07 
                 1.319848032 
               
               
                 Example 134 (DKC1125E5) 
                 1.09 
                 0.04 
                 1.296825956 
               
               
                 Example 135 (DKC1125E6) 
                 1.30 
                 0.06 
                 1.484699948 
               
               
                 Example 136 (DKC1125E7) 
                 1.17 
                 0.03 
                 1.296697958 
               
               
                 Example 137 (DKC1125F1) 
                 1.19 
                 0.04 
                 1.231017841 
               
               
                 Example 138 (DKC1125F2) 
                 1.15 
                 0.04 
                 1.258420919 
               
               
                 Example 139 (DKC1125F3) 
                 1.01 
                 0.03 
                 1.313526706 
               
               
                 Example 140 (DKC1125F4) 
                 1.15 
                 0.03 
                 1.552957467 
               
               
                 Example 141 (DKC1125F5) 
                 1.06 
                 0.03 
                 1.392812365 
               
               
                 Example 142 (DKC1125F6) 
                 1.12 
                 0.03 
                 1.800082616 
               
               
                 Example 143 (DKC1125F7) 
                 1.16 
                 0.03 
                 0.802837469 
               
               
                 Example 144 (DKC1125F8) 
                 1.08 
                 0.02 
                 1.284340392 
               
               
                 Example 145 (DKC1125F9) 
                 1.10 
                 0.03 
                 1.432724279 
               
               
                 Example 146 (DKC1125F10) 
                 1.16 
                 0.05 
                 0.747426234 
               
               
                 Example 147 (DKC1125F11) 
                 1.10 
                 0.04 
                 0.952431514 
               
               
                 Example 148 (DKC1125F12) 
                 1.44 
                 0.04 
                 1.84351155 
               
               
                 Example 149 (DKC1125F13) 
                 1.07 
                 0.03 
                 1.260689964 
               
               
                 Example 150 (DKC1125F14) 
                 1.14 
                 0.03 
                 1.071189823 
               
               
                 EV 
                   
                   
                 1 
               
               
                 KIT 
                   
                   
                 1.580081278 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                 TABLE 18 
               
               
                   
               
               
                   
                 Relative 
                   
                   
               
               
                   
                 KAI 
                   
                 In vivo 
               
               
                   
                 promoter 
                   
                 relative 
               
               
                   
                 activity 
                 SD 
                 invation 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 cont 
                 1.00 
                 0.035728039 
                   
               
               
                 #25 
                 1.72 
                 0.051949457 
                   
               
               
                 Example 151 (DKC1125g1) 
                 1.05 
                 0.015406669 
                 1.212117692 
               
               
                 Example 152 (DKC1125g2) 
                 1.08 
                 0.05020165 
                 1.160090569 
               
               
                 Example 153 (DKC1125g3) 
                 1.05 
                 0.022504904 
                 1.095142017 
               
               
                 Example 154 (DKC1125g4) 
                 1.05 
                 0.033408055 
                 1.172964579 
               
               
                 Example 155 (DKC1125g5) 
                 0.99 
                 0.036569054 
                 1.150687562 
               
               
                 Example 156 (DKC1125g6) 
                 0.99 
                 0.040959537 
                 1.15752525 
               
               
                 Example 157 (DKC1125g7) 
                 1.05 
                 0.059800725 
                 1.088757172 
               
               
                 Example 158 (DKC1125g8) 
                 1.00 
                 0.021721992 
                 1.170875812 
               
               
                 Example 159 (DKC1125g9) 
                 0.99 
                 0.05344675 
                 1.059322396 
               
               
                 Example 160 (DKC1125g10) 
                 1.05 
                 0.039047303 
                 1.066565508 
               
               
                 Example 161 (DKC1125g11) 
                 0.95 
                 0.11431494 
                 1.121492247 
               
               
                 Example 162 (DKC1125g12) 
                 0.99 
                 0.04776634 
                 1.042903884 
               
               
                 Example 163 (DKC1125g13) 
                 1.10 
                 0.046391673 
                 1.162700934 
               
               
                 Example 164 (DKC1125g14) 
                 0.98 
                 0.027883891 
                 1.088399165 
               
               
                 Example 165 (DKC1125g15) 
                 1.07 
                 0.031173347 
                 1.133081227 
               
               
                 Example 166 (DKC1125g16) 
                 1.01 
                 0.04132212 
                 1.094224477 
               
               
                 Example 167 (DKC1125g17) 
                 1.04 
                 0.034419555 
                 1.159165916 
               
               
                 Example 168 (DKC1125g18) 
                 1.05 
                 0.051934534 
                 1.199229456 
               
               
                 Example 169 (DKC1125g19) 
                 0.99 
                 0.034417249 
                 1.186412348 
               
               
                 Example 170 (DKC1125g20) 
                 1.03 
                 0.019980382 
                 1.244191285 
               
               
                 Example 171 (DKC1125g21) 
                 1.07 
                 0.030083522 
                 1.190841197 
               
               
                 Example 172 (DKC1125g22) 
                 0.93 
                 0.042731342 
                 1.159585566 
               
               
                 Example 173 (DKC1125g23) 
                 1.07 
                 0.048598895 
                 1.120954052 
               
               
                 Example 174 (DKC1125g24) 
                 1.07 
                 0.045490053 
                 1.144233961 
               
               
                 Example 175 (DKC1125g25) 
                 0.97 
                 0.030587107 
                 1.148880933 
               
               
                 Example 176 (DKC1125g26) 
                 1.08 
                 0.03777825 
                 1.260190147 
               
               
                 Example 177 (DKC1125g27) 
                 0.95 
                 0.025583177 
                 1.158698848 
               
               
                 Example 178 (DKC1125g28) 
                 0.91 
                 0.027068291 
                 1.228353644 
               
               
                 Example 179 (DKC1125g29) 
                 0.97 
                 0.028444174 
                 1.081229551 
               
               
                 Example 180 (DKC1125g30) 
                 1.09 
                 0.030961498 
                 1.252928067 
               
               
                 Example 181 (DKC1125g31) 
                 1.06 
                 0.047857709 
                 1.193766893 
               
               
                 Example 182 (DKC1125g32) 
                 0.93 
                 0.050219774 
                 1.094710513 
               
               
                 Example 183 (DKC1125g33) 
                 0.96 
                 0.034837465 
                 1.193745555 
               
               
                 Example 184 (DKC1125g34) 
                 0.98 
                 0.011433171 
                 1.113907724 
               
               
                 Example 185 (DKC1125g35) 
                 1.12 
                 0.020945265 
                 1.113542605 
               
               
                 Example 186 (DKC1125g36) 
                 1.06 
                 0.023271028 
                 1.144717625 
               
               
                 Example 187 (DKC1125g37) 
                 1.03 
                 0.045390634 
                 1.23497558 
               
               
                 Example 188 (DKC1125g38) 
                 0.92 
                 0.028776265 
                 1.123381858 
               
               
                 Example 189 (DKC1125g39) 
                 0.90 
                 0.024634724 
                 1.18502774 
               
               
                 Example 190 (DKC1125g40) 
                 0.83 
                 0.048934241 
                 1.202513159 
               
               
                 Example 191 (DKC1125g41) 
                 0.84 
                 0.025066468 
                 1.105775523 
               
               
                 Example 192 (DKC1125g42) 
                 0.92 
                 0.024830991 
                 1.250301105 
               
               
                 Example 193 (DKC1125g43) 
                 0.82 
                 0.019545606 
                 1.214076059 
               
               
                 Example 194 (DKC1125g44) 
                 1.01 
                 0.040004484 
                 1.259054483 
               
               
                 Example 195 (DKC1125g45) 
                 1.08 
                 0.037760393 
                 1.139454218 
               
               
                 Example 196 (DKC1125g46) 
                 0.84 
                 0.015353354 
                 1.112954621 
               
               
                 Example 197 (DKC1125g47) 
                 0.92 
                 0.025999083 
                 1.213772583 
               
               
                 Example 198 (DKC1125g48) 
                 0.87 
                 0.033098976 
                 1.149841149 
               
               
                 Example 199 (DKC1125g49) 
                 0.97 
                 0.030843205 
                 1.105472047 
               
               
                 Example 200 (DKC1125g50) 
                 1.01 
                 0.033825902 
                 1.073633174 
               
               
                 EV 
                   
                   
                 1.047669401 
               
               
                 KIT 
                   
                   
                 1.287517189 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                 TABLE 19 
               
               
                   
               
               
                   
                 Relative 
                   
                   
               
               
                   
                 KAI 
                   
                 In vivo 
               
               
                   
                 promoter 
                   
                 relative 
               
               
                   
                 activity 
                 SD 
                 invation 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 cont 
                 1 
                 0.045599246 
                   
               
               
                 #25 
                 2.657463873 
                 0.063163146 
                   
               
               
                 Example 201 (DKC1125h1) 
                 1.45738535 
                 0.079462555 
                 0.928329384 
               
               
                 Example 202 (DKC1125h2) 
                 1.312848554 
                 0.057783663 
                 1.13776894 
               
               
                 Example 203 (DKC1125h3) 
                 1.053432732 
                 0.023471095 
                 1.17750128 
               
               
                 Example 204 (DKC1125h4) 
                 1.304834442 
                 0.036602658 
                 1.095031374 
               
               
                 Example 205 (DKC1125h5) 
                 1.096349677 
                 0.043106182 
                 1.165632777 
               
               
                 Example 206 (DKC1125h6) 
                 1.050041236 
                 0.030215636 
                 1.10968126 
               
               
                 Example 207 (DKC1125h7) 
                 1.430985662 
                 0.052532617 
                 1.036274662 
               
               
                 Example 208 (DKC1125h8) 
                 1.141502143 
                 0.042137772 
                 1.18447855 
               
               
                 Example 209 (DKC1125h9) 
                 1.124707639 
                 0.052152941 
                 1.069956065 
               
               
                 Example 210 (DKC1125h10) 
                 1.02640633 
                 0.023509915 
                 0.927379237 
               
               
                 Example 211 (DKC1125h11) 
                 1.440195485 
                 0.035947539 
                 0.869891769 
               
               
                 Example 212 (DKC1125h12) 
                 1.012011355 
                 0.015036199 
                 1.218681463 
               
               
                 Example 213 (DKC1125h13) 
                 1.136015792 
                 0.03074789 
                 1.209439556 
               
               
                 Example 214 (DKC1125h14) 
                 1.085757281 
                 0.034425293 
                 1.244025861 
               
               
                 Example 215 (DKC1125h15) 
                 0.975093626 
                 0.03535319 
                 1.304068487 
               
               
                 Example 216 (DKC1125h16) 
                 1.202091224 
                 0.03332846 
                 1.254991844 
               
               
                 Example 217 (DKC1125h17) 
                 1.179071269 
                 0.036269836 
                 1.265776846 
               
               
                 Example 218 (DKC1125h18) 
                 1.333459412 
                 0.057451894 
                 1.169109505 
               
               
                 Example 219 (DKC1125h19) 
                 1.27302544 
                 0.040484495 
                 1.145489183 
               
               
                 Example 220 (DKC1125h20) 
                 1.14776276 
                 0.03159924 
                 0.932439544 
               
               
                 Example 221 (DKC1125h21) 
                 0.961286968 
                 0.031480315 
                 1.32159739 
               
               
                 Example 222 (DKC1125h22) 
                 1.196063971 
                 0.044053472 
                 1.275056854 
               
               
                 Example 223 (DKC1125h23) 
                 1.096834141 
                 0.018382377 
                 1.194515818 
               
               
                 Example 224 (DKC1125h24) 
                 1.133087247 
                 0.025384233 
                 1.249752938 
               
               
                 Example 225 (DKC1125h25) 
                 1.349029621 
                 0.045429658 
                 1.234879207 
               
               
                 Example 226 (DKC1125h26) 
                 1.088612385 
                 0.05682518 
                 1.348570612 
               
               
                 Example 227 (DKC1125h27) 
                 1.012540188 
                 0.01932845 
                 1.153121316 
               
               
                 Example 228 (DKC1125h28) 
                 0.982240102 
                 0.013079669 
                 1.277757272 
               
               
                 Example 229 (DKC1125h29) 
                 1.058902384 
                 0.033688612 
                 1.244864086 
               
               
                 Example 230 (DKC1125h30) 
                 1.075326759 
                 0.032648818 
                 1.266617453 
               
               
                 EV 
                   
                   
                 1 
               
               
                 KIT 
                   
                   
                 1.205379404 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                 TABLE 20 
               
               
                   
               
               
                   
                 Relative  
                   
                   
               
               
                   
                 KAI 
                   
                 In vivo 
               
               
                   
                 promoter 
                   
                 relative 
               
               
                   
                 activity 
                 SD 
                 invation 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 cont 
                 1 
                 0.129112624 
                   
               
               
                 Example 231 (DKC1125i1) 
                 1.556398647 
                 0.356950339 
                 1.122056659 
               
               
                 Example 232 (DKC1125i2) 
                 1.231242745 
                 0.088151665 
                 1.125203154 
               
               
                 Example 233 (DKC1125i3) 
                 1.151771581 
                 0.044393835 
                 1.025831359 
               
               
                 Example 234 (DKC1125i4) 
                 1.549705281 
                 0.215596374 
                 1.119107161 
               
               
                 Example 235 (DKC1125i5) 
                 1.444493299 
                 0.11360543 
                 1.13306392 
               
               
                 Example 236 (DKC1125i6) 
                 1.301399979 
                 0.118292539 
                 1.111736154 
               
               
                 Example 237 (DKC1125i7) 
                 1.555303186 
                 0.075592034 
                 1.113930493 
               
               
                 Example 238 (DKC1125i8) 
                 1.603237137 
                 0.192740023 
                 1.119662586 
               
               
                 Example 239 (DKC1125i9) 
                 1.080807827 
                 0.099370588 
                 1.13515976 
               
               
                 Example 240 (DKC1125i10) 
                 1.304013005 
                 0.126278512 
                 1.1003048 
               
               
                 Example 241 (DKC1125i11) 
                 1.103382864 
                 0.02639089 
                 1.126095117 
               
               
                 Example 242 (DKC1125i12) 
                 1.17351246 
                 0.217832762 
                 1.146366755 
               
               
                 Example 243 (DKC1125i13) 
                 1.476648593 
                 0.246946908 
                 1.105040959 
               
               
                 Example 244 (DKC1125i14) 
                 1.514132953 
                 0.093639982 
                 1.100228189 
               
               
                 Example 245 (DKC1125i15) 
                 1.34532394 
                 0.199290669 
                 1.126305796 
               
               
                 Example 246 (DKC1125i16) 
                 1.876396336 
                 0.278631225 
                 1.147773102 
               
               
                 Example 247 (DKC1125i17) 
                 1.273772255 
                 0.177238928 
                 1.124489037 
               
               
                 Example 248 (DKC1125i18) 
                 1.300907524 
                 0.166614644 
                 1.115525629 
               
               
                 Example 249 (DKC1125i19) 
                 1.346344025 
                 0.217908326 
                 1.112617173 
               
               
                 Example 250 (DKC1125i20) 
                 1.250584162 
                 0.122450664 
                 0.978086712 
               
               
                 Example 251 (DKC1125i21) 
                 2.365102536 
                 0.369710339 
                 1.197359133 
               
               
                 Example 252 (DKC1125i22) 
                 1.560973955 
                 0.242281458 
                 1.165185534 
               
               
                 Example 253 (DKC1125i23) 
                 0.963357336 
                 0.077755496 
                 1.421250062 
               
               
                 Example 254 (DKC1125i24) 
                 2.076943564 
                 0.156698532 
                 0.914289467 
               
               
                 Example 255 (DKC1125i25) 
                 1.731617111 
                 0.258660774 
                 1.173719376 
               
               
                 Example 256 (DKC1125i26) 
                 2.249993719 
                 0.25040892 
                 1.266677793 
               
               
                 Example 257 (DKC1125i27) 
                 1.360595066 
                 0.170128384 
                 1.337561493 
               
               
                 Example 258 (DKC1125i28) 
                 2.308821978 
                 0.32046683 
                 1.223037271 
               
               
                 Example 259 (DKC1125i29) 
                 1.227092054 
                 0.258824364 
                 1.251473381 
               
               
                 Example 260 (DKC1125i30) 
                 1.328778963 
                 0.078885596 
                 1.092134856 
               
               
                 Example 261 (DKC1125i31) 
                 1.251468571 
                 0.187588116 
                 1.196759931 
               
               
                 Example 262 (DKC1125i32) 
                 1.541190334 
                 0.238186218 
                 1.089562938 
               
               
                 Example 263 (DKC1125i33) 
                 2.229416139 
                 0.213378821 
                 1.301160646 
               
               
                 Example 264 (DKC1125i34) 
                 1.905300423 
                 0.18881145 
                 1.199189572 
               
               
                 Example 265 (DKC1125i35) 
                 1.912227454 
                 0.149517135 
                 1.342792884 
               
               
                 Example 266 (DKC1125i36) 
                 2.212346045 
                 0.113129725 
                 1.400822467 
               
               
                 Example 267 (DKC1125i37) 
                 3.559546841 
                 0.38015012 
                 0.904641718 
               
               
                 Example 268 (DKC1125i38) 
                 1.599719602 
                 0.127926085 
                 1.220238582 
               
               
                 Example 269 (DKC1125i39) 
                 1.37605212 
                 0.095531412 
                 1.162686287 
               
               
                 Example 270 (DKC1125i40) 
                 1.468374849 
                 0.151630778 
                 1.237535549 
               
               
                 Example 271 (DKC1125i41) 
                 1.30625669 
                 0.15116153 
                 1.227526454 
               
               
                 Example 272 (DKC1125i42) 
                 1.589342874 
                 0.11944405 
                 1.230201962 
               
               
                 Example 273 (DKC1125i43) 
                 1.195039773 
                 0.196597091 
                 1.17105928 
               
               
                 Example 274 (DKC1125i44) 
                 5.269907991 
                 0.405048334 
                 1.21949993 
               
               
                 Example 275 (DKC1125i45) 
                 6.848650523 
                 1.198566554 
                 1.145663608 
               
               
                 Example 276 (DKC1125i46) 
                 3.393903609 
                 0.21257212 
                 1.224121918 
               
               
                 Example 277 (DKC1125i47) 
                 1.300399994 
                 0.124870762 
                 1.126237302 
               
               
                 Example 278 (DKC1125i48) 
                 1.380129948 
                 0.265090603 
                 1.217358561 
               
               
                 Example 279 (DKC1125i49) 
                 2.276031015 
                 0.299057444 
                 1.187429924 
               
               
                 Example 280 (DKC1125i50) 
                 1.628018171 
                 0.189568898 
                 1.19499449 
               
               
                 Example 281 (DKC1125i51) 
                 1.518168068 
                 0.18664641 
                 1.236428774 
               
               
                 Example 282 (DKC1125i52) 
                 1.470347181 
                 0.166307965 
                 1.213865002 
               
               
                 Example 283 (DKC1125i53) 
                 1.328550323 
                 0.189829759 
                 1.235314781 
               
               
                 Example 284 (DKC1125i54) 
                 1.443445576 
                 0.142080934 
                 1.275521989 
               
               
                 Example 285 (DKC1125i55) 
                 1.471193902 
                 0.109249503 
                 1.246500426 
               
               
                 Example 286 (DKC1125i56) 
                 1.429571413 
                 0.231373226 
                 1.232636867 
               
               
                 Example 287 (DKC1125i57) 
                 2.059948845 
                 0.157138042 
                 1.375947375 
               
               
                 Example 288 (DKC1125i58) 
                 1.730695015 
                 0.22183601 
                 1.221513779 
               
               
                 Example 289 (DKC1125i59) 
                 1.614154058 
                 0.09440281 
                 1.262830168 
               
               
                 Example 290 (DKC1125i60) 
                 1.231245258 
                 0.244002014 
                 0.92340877 
               
               
                 Example 291 (DKC1125i61) 
                 1.61539022 
                 0.243489702 
                 1.125527523 
               
               
                 Example 292 (DKC1125i62) 
                 1.448628915 
                 0.252312759 
                 1.238358412 
               
               
                 Example 293 (DKC1125i63) 
                 1.246390758 
                 0.226601045 
                 1.174329078 
               
               
                 Example 294 (DKC1125i64) 
                 1.565235197 
                 0.14861702 
                 1.033340391 
               
               
                 Example 295 (DKC1125i65) 
                 1.524549881 
                 0.099988167 
                 1.310621189 
               
               
                 Example 296 (DKC1125i66) 
                 1.531260835 
                 0.185676483 
                 1.026110264 
               
               
                 Example 297 (DKC1125i67) 
                 1.327040296 
                 0.133929746 
                 1.230702417 
               
               
                 Example 298 (DKC1125i68) 
                 1.341102898 
                 0.081503164 
                 1.213135975 
               
               
                 Example 299 (DKC1125i69) 
                 2.166005035 
                 0.449875932 
                 1.06790064 
               
               
                 Example 300 (DKC1125i70) 
                 1.911006367 
                 0.368118524 
                 0.986889529 
               
               
                 Example 301 (DKC1125i71) 
                 1.614450536 
                 0.220205424 
                 1.145603457 
               
               
                 Example 302 (DKC1125i72) 
                 1.412219916 
                 0.242568691 
                 1.175212092 
               
               
                 Example 303 (DKC1125i73) 
                 1.846492264 
                 0.176562687 
                 1.137812724 
               
               
                 Example 304 (DKC1125i74) 
                 1.236122069 
                 0.047645221 
                 1.193134627 
               
               
                 Example 305 (DKC1125i75) 
                 1.14356065 
                 0.045375583 
                 1.186202848 
               
               
                 EV 
                   
                   
                 1 
               
               
                 KIT 
                   
                   
                 1.369215237