Patent Publication Number: US-10323045-B2

Title: Thienopyrimidine derivatives as NIK inhibitors

Description:
CROSS REFERENCE TO RELATED APPLICATIONS 
     This application is a national stage of PCT Application No. PCT/EP2015/074430, filed Oct. 22, 2015, which claims priority for EPO Patent Application No. 14190077.9, filed Oct. 23, 2014, all of which are hereby incorporated by reference in their entirety. 
     FIELD OF THE INVENTION 
     The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders. 
     BACKGROUND OF THE INVENTION 
     The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer and inflammatory disorders. Nuclear factor-kappa B (NF-κB) is a transcription factor regulating the expression of various genes involved in the immune response, cell proliferation, apoptosis, and carcinogenesis. NF-κB dependent transcriptional activation is a tightly controlled signaling pathway, through sequential events including phosphorylation and protein degradation. NIK is a serine/threonine kinase which regulates NF-κB pathway activation. There are two NF-κB signaling pathways, the canonical and the non-canonical. NIK has a role in both but has been shown to be indispensable for the non-canonical signaling pathway where it phosphorylates IKKα, leading to the partial proteolysis of p100; liberating p52 which then heterodimerizes with RelB, translocates to the nucleus and mediates gene expression. The non-canonical pathway is activated by only a handful of ligands such as CD40 ligands, B-cell activating factor (BAFF), lymphotoxin β receptor ligands and TNF-related weak inducer of apoptosis (TWEAK) and NIK has been shown to be required for activation of the pathway by these ligands. Because of its key role, NIK expression is tightly regulated. Under normal non-stimulated conditions NIK protein levels are very low, this is due to its interaction with a range of TNF receptor associated factors (TRAF), which are ubiquitin ligases and result in degradation of NIK. It is believed that when the non-canonical pathway is stimulated by ligands, the activated receptors now compete for TRAFs, dissociating the TRAF-NIK complexes and thereby increasing the levels of NIK. (Thu and Richmond,  Cytokine Growth F. R.  2010, 21, 213-226) 
     Research has shown that blocking the NF-κB signaling pathway in cancer cells can cause cells to stop proliferating, to die and to become more sensitive to the action of other anti-cancer therapies. A role for NIK has been shown in the pathogenesis of both hematological malignancies and solid tumours. 
     The NF-κB pathway is dysregulated in multiple myeloma due to a range of diverse genetic abnormalities that lead to the engagement of the canonical and non-canonical pathways (Annuziata et al.  Cancer Cell  2007, 12, 115-130; Keats et al.  ibid  2007, 12, 131-144; Demchenko et al.  Blood  2010, 115, 3541-3552). Myeloma patient samples frequently have increased levels of NIK activity. This can be due to chromosomal amplification, translocations (that result in NIK proteins that have lost TRAF binding domains), mutations (in the TRAF binding domain of NIK) or TRAF loss of function mutations. Researchers have shown that myeloma cell lines can be dependent on NIK for proliferation; in these cell lines if NIK activity is reduced by either shRNA or compound inhibition, this leads to a failure in NF-κB signaling and the induction of cell death (Annuziata 2007). 
     In a similar manner, mutations in TRAF and increased levels of NIK have also been seen in samples from Hodgkin lymphoma (HL) patients. Once again proliferation of cell lines derived from HL patients is susceptible to inhibition of NIK function by both shRNA and compounds (Ranuncolo et al.  Blood  First Edition Paper, 2012, DOI 10.1182/blood-2012-01-405951). 
     NIK levels are also enhanced in adult T cell leukemia (ATL) cells and targeting NIK with shRNA reduced ATL growth in vivo (Saitoh et al.  Blood  2008, 111, 5118-5129). It has been demonstrated that the API2-MALT1 fusion oncoprotein created by the recurrent translocation t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma induces proteolytic cleavage of NF-κB-inducing kinase (NIK) at arginine 325. NIK cleavage generates a C-terminal NIK fragment that retains kinase activity and is resistant to proteasomal degradation (due to loss of TRAF binding region). The presence of this truncated NIK leads to constitutive non-canonical NF-κB signaling, enhanced B cell adhesion, and apoptosis resistance. Thus NIK inhibitors could represent a new treatment approach for refractory t(11;18)-positive MALT lymphoma (Rosebeck et al.  Science  2011, 331, 468-472). 
     NIK aberrantly accumulates in diffuse large B-cell lymphoma (DLBCL) cells due to constitutive activation of B-cell activation factor (BAFF) through interaction with autochthonous B-lymphocyte stimulator (BLyS) ligand. NIK accumulation in human DLBCL cell lines and patient tumor samples suggested that constitutive NIK kinase activation is likely to be a key signaling mechanism involved in abnormal lymphoma tumor cell proliferation. Growth assays showed that using shRNA to inhibit NIK kinase protein expression in GCB- and ABC-like DLBCL cells decreased lymphoma cell growth in vitro, implicating NIK-induced NF-κB pathway activation as having a significant role in DLBCL proliferation (Pham et al.  Blood  2011, 117, 200-210). 
     As mentioned a role of NIK in tumour cell proliferation is not restricted to hematological cells, there are reports that NIK protein levels are stabilised in some pancreatic cancer cell lines and as seen in blood cells proliferation of these pancreatic cancer lines are susceptible to NIK siRNA treatment (Nishina et al.  Biochem. Bioph. Res. Co.  2009, 388, 96-101). Constitutive activation of NF-κB, is preferentially involved in the proliferation of basal-like subtype breast cancer cell lines, including elevated NIK protein levels in specific lines (Yamamoto et al.  Cancer Sci.  2010. 101, 2391-2397). In melanoma tumours, tissue microarray analysis of NIK expression revealed that there was a statistically significant elevation in NIK expression when compared with benign tissue. Moreover, shRNA techniques were used to knock-down NIK, the resultant NIK-depleted melanoma cell lines exhibited decreased proliferation, increased apoptosis, delayed cell cycle progression and reduced tumor growth in a mouse xenograft model (Thu et al.  Oncogene  2011, 1-13). A wealth of evidence showed that NF-κB is often constitutively activated in non-small cell lung cancer tissue specimens and cell lines. Depletion of NIK by RNAi induced apoptosis and affected efficiency of anchorage-independent NSCLC cell growth. 
     In addition research has shown that NF-κB controls the expression of many genes involved in inflammation and that NF-κB signalling is found to be chronically active in many inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, sepsis and others. Thus pharmaceutical agents capable of inhibiting NIK and thereby reducing NF-κB signaling pathway can have a therapeutic benefit for the treatment of diseases and disorders for which over-activation of NF-κB signaling is observed. 
     Dysregulated NF-κB activity is associated with colonic inflammation and cancer, and it has been shown that Nlrp12 deficient mice were highly susceptible to colitis and colitis-associated colon cancer. In this context work showed that NLRP12 functions as a negative regulator of the NF-κB pathway through its interaction and regulation of NIK and TRAF3, and as a checkpoint of critical pathways associated with inflammation and inflammation-associated tumorigenesis (Allen et al.  Immunity  2012, 36, 742-754). 
     Tumor necrosis factor (TNF)-α, is secreted in response to inflammatory stimuli in diseases such as rheumatoid arthritis and inflammatory bowel disease. In a series of experiments in colonic epithelial cells and mouse embryonic fibroblasts, TNF-α mediates both apoptosis and inflammation, stimulating an inflammatory cascade through the non-canonical pathway of NF-κB activation, leading to increased nuclear RelB and p52. TNF-α induced the ubiquitination of TRAFs, which interacts with NIK, leading to increased levels of phospho-NIK (Bhattacharyya et al.  J Biol. Chem.  2011, 285, 39511-39522). 
     Inflammatory responses are a key component of chronic obstructive pulmonary disease (COPD) as such it has been shown that NIK plays a key role in exacerbating the disease following infection with the Gram-negative bacterium nontypeable  Hemophilus influenza  (Shuto et al.  PNAS  2001, 98, 8774-8779). Likewise cigarette smoke (CS) contains numerous reactive oxygen/nitrogen species, reactive aldehydes, and quinones, which are considered to be some of the most important causes of the pathogenesis of chronic inflammatory lung diseases, such as COPD and lung cancer. Increased levels of NIK and p-IKKα have been observed in peripheral lungs of smokers and patients with COPD. In addition it has been shown that endogenous NIK is recruited to promoter sites of pro-inflammatory genes to induce post-translational modification of histones, thereby modifying gene expression profiles, in response to CS or TNFα (Chung et al.  PLoS ONE  2011, 6(8): e23488. doi: 10.1371/journal.pone.0023488). A shRNA screen was used in an in vitro model of oxidative stress induced cell death (as a model of COPD) to interrogate a human druggable genome siRNA library in order to identify genes that modulate the cellular response to stress. NIK was one of the genes identified in this screen as a potential new therapeutic target to modulate epithelial apoptosis in chronic lung diseases (Wixted et al.  Toxicol. In Vitro  2010, 24, 310-318). 
     Diabetic individuals can be troubled by a range of additional manifestations associated with inflammation. One such complication is cardiovascular disease and it has been shown that there are elevated levels of p-NIK, p-IKK-α/β and p-IκB-α in diabetic aortic tissues (Bitar et al.  Life Sci.  2010, 86, 844-853). In a similar manner, NIK has been shown to regulate proinflammatory responses of renal proximal tubular epithelial cells via mechanisms involving TRAF3. This suggests a role for NF-κB noncanonical pathway activation in modulating diabetes-induced inflammation in renal tubular epithelium (Zhao et al.  Exp. Diabetes Res.  2011, 1-9). The same group has shown that NIK plays a critical role in noncanonical NF-κB pathway activation, induced skeletal muscle insulin resistance in vitro, suggesting that NIK could be an important therapeutic target for the treatment of insulin resistance associated with inflammation in obesity and type 2 diabetes (Choudhary et al.  Endocrinology  2011, 152, 3622-3627). NF-κB is an important component of both autoimmunity and bone destruction in rheumatoid arthritis (RA). Mice lacking functional NIK have no peripheral lymph nodes, defective B and T cells, and impaired receptor activator of NF-κB ligand-stimulated osteoclastogenesis. Aya et al. ( J. Clin. Invest.  2005, 115, 1848-1854) investigated the role of NIK in murine models of inflammatory arthritis using Nik−/− mice. The serum transfer arthritis model was initiated by preformed antibodies and required only intact neutrophil and complement systems in recipients. While Nik−/− mice had inflammation equivalent to that of Nik+/+ controls, they showed significantly less periarticular osteoclastogenesis and less bone erosion. In contrast, Nik−/− mice were completely resistant to antigen-induced arthritis (AIA), which requires intact antigen presentation and lymphocyte function but not lymph nodes. Additionally, transfer of Nik+/+ splenocytes or T cells to Rag2−/− mice conferred susceptibility to AIA, while transfer of Nik−/− cells did not. Nik−/− mice were also resistant to a genetic, spontaneous form of arthritis, generated in mice expressing both the KRN T cell receptor and H-2g7. The same group used transgenic mice with OC-lineage expression of NIK lacking its TRAF3 binding domain (NT3), to demonstrate that constitutive activation of NIK drives enhanced osteoclastogenesis and bone resorption, both in basal conditions and in response to inflammatory stimuli (Yang et al.  PLoS One  2010, 5, 1-9, e15383). Thus this group concluded that NIK is important in the immune and bone-destructive components of inflammatory arthritis and represents a possible therapeutic target for these diseases. 
     It has also been hypothesized that manipulating levels of NIK in T cells may have therapeutic value. Decreasing NIK activity in T cells might significantly ameliorate autoimmune and alloresponses, like GVHD (Graft Versus Host Disease) and transplant rejection, without crippling the immune system as severely as do inhibitors of canonical NF-κB activation. 
     WO2010/042337 describes novel 6-azaindole aminopyrimidine derivatives having NIK inhibitory activity. 
     WO2009/158011 describes alkynyl alcohols as kinase inhibitors. 
     WO2012/123522 describes 6,5-heterocyclic propargylic alcohol compounds and uses therefor. 
     DESCRIPTION OF THE INVENTION 
     The present invention concerns novel compounds of Formula (I): 
                         
and tautomers and stereoisomeric forms thereof, wherein
     R 0  is selected from the group of hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl and C 1-4 alkyl substituted with one —OC 1-4 alkyl;   

     Het is a bicyclic heterocyclic radical selected from 
     
       
         
         
             
             
         
       
         
         R 1a  is selected from the group of hydrogen; C 1-4 alkyl; and C 1-4 alkyl substituted with one or more fluoro substituents; 
         R 2a  is selected from the group of hydrogen; C 1-4 alkyl; C 1-4 alkyl substituted with one or more fluoro substituents; C 3-6 cycloalkyl; and Het 1a ; 
         or R 1a  and R 2a  together with the carbon atom to which they are attached form a C 3-6 cycloalkyl; 
         R 1b  is selected from the group of hydrogen; C 1-4 alkyl; and C 1-4 alkyl substituted with one or more fluoro substituents; 
         R 2b  is selected from the group of hydrogen; C 1-4 alkyl; C 1-4 alkyl substituted with one or more fluoro substituents; C 3-6 cycloalkyl; and Het 1b ; 
         or R 1b  and R 2b  together with the carbon atom to which they are attached form a C 3-6 cycloalkyl; 
         Het 1a  is a heteroaryl selected from the group of thienyl, thiazolyl, pyrrolyl, oxazolyl, oxadiazolyl, pyrazolyl, imidazolyl, isoxazolyl, isothiazolyl, pyridinyl and pyrimidinyl, each of which may be optionally substituted with one or two substituents independently selected from halogen, cyano, C 1-4 alkyl, C 1-4 alkyloxy, C 1-4 alkyl substituted with one or more fluoro substituents, and C 1-4 alkyloxy substituted with one or more fluoro substituents; 
         Het 1b  is a heteroaryl selected from the group of thienyl, thiazolyl, pyrrolyl, oxazolyl, oxadiazolyl, pyrazolyl, imidazolyl, isoxazolyl, and isothiazolyl, each of which may be optionally substituted with one or two substituents independently selected from halogen, cyano, C 1-4 alkyl, C 1-4 alkyloxy, C 1-4 alkyl substituted with one or more fluoro substituents, and C 1-4 alkyloxy substituted with one or more fluoro substituents; 
         R 3a  is selected from the group of hydrogen; halogen; cyano; C 3-6 cycloalkyl; C 1-6 alkyl; 
         Het 4a ; C 1-6 alkyl substituted with one or more fluoro substituents; —OC 1-6 alkyl; —OC 1-6 alkyl substituted with one or more fluoro substituents; and C 1-6 alkyl substituted with one substituent selected from —NR 3aa R 3ab  and —OC 1-4 alkyl; 
         R 3b  is selected from the group of hydrogen; halogen; cyano; C 3-6 cycloalkyl; C 1-6 alkyl; 
         Het 4b ; C 1-6 alkyl substituted with one or more fluoro substituents; —OC 1-6 alkyl; —OC 1-6 alkyl substituted with one or more fluoro substituents; and C 1-6 alkyl substituted with one substituent selected from —NR 3ba R 3bb  and —OC 1-4 alkyl; 
         Het 4a  is a heteroaryl selected from the group of piperidinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl, piperazinyl, morpholinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl and C 1-4 alkyl substituted with one or more fluoro substituents; 
         Het 4b  is a heteroaryl selected from the group of piperidinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl, piperazinyl, morpholinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl and C 1-4 alkyl substituted with one or more fluoro substituents; 
         R 3aa , R 3ab , R 3ba  and R 3bb  are each independently selected from hydrogen and C 1-4 alkyl; 
         R 4a  and R 4b  are hydrogen; 
         R 5  is selected from the group of hydrogen; cyano; C 1-4 alkyl; C 1-4 alkyl substituted with one or more fluoro substituents; C 1-4 alkyl substituted with one substituent selected from the group of —NR 5a R 5b , —OC 1-4 alkyl, and Het 5 ; 
         R 6  is selected from the group of hydrogen; cyano; C 1-4 alkyl; C 1-4 alkyl substituted with one or more fluoro substituents; C 1-4 alkyl substituted with one substituent selected from the group of NR 6a R 6b , —OC 1-4 alkyl, and Het 6 ; 
         R 5a , R 5b , R 6a  and R 6b  are each independently selected from the group of hydrogen and C 1-4 alkyl; 
         Het 5  is a heterocyclyl selected from the group of piperidinyl, piperazinyl, morpholinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl and C 1-4 alkyl substituted with one or more fluoro substituents; 
         Het 6  is a heterocyclyl selected from the group of piperidinyl, piperazinyl, morpholinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl and C 1-4 alkyl substituted with one or more fluoro substituents; 
         R 7  is selected from the group of hydrogen; Het 2a ; R 10a ; C 1-6 alkyl optionally substituted with one Het 3a ; and C 2-6 alkyl substituted with one or more substituents independently selected from the group of fluoro, —NR 7a R 7b , and —OR 7c ; 
         R 7a , R 7b  and R 7c  are each independently selected from hydrogen and C 1-6 alkyl; 
         Het 2a  is a heterocyclyl, bound through any available carbon atom, selected from the group of piperidinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl, 
         C 1-4 alkyl substituted with one —OC 1-4 alkyl, 
         C 1-4 alkyl substituted with one C 3-6 cycloalkyl, 
         and C 1-4 alkyl substituted with one or more fluoro substituents; 
         Het 3a  is a heterocyclyl selected from the group of morpholinyl, piperidinyl, piperazinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl, 
         C 1-4 alkyl substituted with one —OC 1-4 alkyl, 
         C 1-4 alkyl substituted with one C 3-6 cycloalkyl, 
         and C 1-4 alkyl substituted with one or more fluoro substituents; 
         R 10a  is C 3-6 cycloalkyl optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 1-4 alkyl substituted with one —OC 1-4 alkyl, and C 1-4 alkyl substituted with one or more fluoro substituents; 
         R 8  is selected from the group of hydrogen; Het 2b ; R 10b ; halogen; cyano; —NR 8a R 8b ; and C 1-6 alkyl optionally substituted with one or more substituents independently selected from the group of fluoro, —NR 8a R 8b , —OR 8c , - and Het 3b ; 
         R 8a , R 8b  and R 8c  are each independently selected from the group of hydrogen and C 1-6 alkyl; 
         Het 2b  is a heterocyclyl selected from the group of morpholinyl, piperidinyl, piperazinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl, 
         C 1-4 alkyl substituted with one —OC 1-4 alkyl, 
         C 1-4 alkyl substituted with one C 3-6 cycloalkyl, 
         and C 1-4 alkyl substituted with one or more fluoro substituents; 
         Het 3b  is a heterocyclyl selected from the group of morpholinyl, piperidinyl, piperazinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl, 
         C 1-4 alkyl substituted with one —OC 1-4 alkyl, 
         C 1-4 alkyl substituted with one C 3-6 cycloalkyl, 
         and C 1-4 alkyl substituted with one or more fluoro substituents; 
         R 10b  is C 3-6 cycloalkyl optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 1-4 alkyl substituted with one —OC 1-4 alkyl, and C 1-4 alkyl substituted with one or more fluoro substituents; 
         and the pharmaceutically acceptable salts, and the solvates thereof. 
       
    
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     The term ‘halo’ or ‘halogen’ as used herein represents fluoro, chloro, bromo and iodo. 
     The prefix ‘C x-y ’ (where x and y are integers) as used herein refers to the number of carbon atoms in a given group. Thus, a C 1-6 alkyl group contains from 1 to 6 carbon atoms, a C 3-6 cycloalkyl group contains from 3 to 6 carbon atoms, and so on. 
     The term ‘C 1-4 alkyl’ as used herein as a group or part of a group represents a straight or branched chain saturated hydrocarbon radical having from 1 to 4 carbon atoms, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, s-butyl, t-butyl and the like. 
     The term ‘C 1-6 alkyl’ as used herein as a group or part of a group represents a straight or branched chain saturated hydrocarbon radical having from 1 to 6 carbon atoms such as the groups defined for C 1-4 alkyl and n-pentyl, n-hexyl, 2-methylbutyl and the like. 
     The term ‘C 2-6 alkyl’ as used herein as a group or part of a group represents a straight or branched chain saturated hydrocarbon radical having from 2 to 6 carbon atoms such as ethyl, n-propyl, isopropyl, n-butyl, s-butyl, t-butyl, n-pentyl, n-hexyl, 2-methylbutyl and the like. 
     The term ‘C 3-6 cycloalkyl’ as used herein as a group or part of a group represents cyclic saturated hydrocarbon radicals having from 3 to 6 carbon atoms such as cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl. 
     The term ‘C 1-4 alkyloxy’ as a group or part of a group refers to a radical having the Formula —OR c  wherein R c  is C 1-4 alkyl. Non-limiting examples of suitable C 1-4 alkyloxy include methyloxy (also methoxy), ethyloxy (also ethoxy), propyloxy, isopropyloxy, butyloxy, isobutyloxy, sec-butyloxy and tert-butyloxy. 
     The term ‘C 1-6 alkyl substituted with one or more substituents’ as used herein as a group or part of a group refers to a C 1-6 alkyl group as defined herein wherein one or more than one hydrogen atom is replaced with another group. The term therefore includes monosubstituted C 1-6 alkyl and also polysubstituted C 1-6 alkyl. There may be one, two, three or more hydrogen atoms replaced with a substituent, so the fully or partially substituted C 1-6 alkyl may have one, two, three or more substituents. Examples of such groups wherein the substituent is for example, fluoro include fluoromethyl, difluoromethyl, trifluoromethyl, fluoroethyl, trifluoroethyl and the like. 
     In general, whenever the term “substituted” is used in the present invention, it is meant, unless otherwise is indicated or is clear from the context, to indicate that one or more hydrogens, in particular from 1 to 4 hydrogens, more in particular from 1 to 3 hydrogens, preferably 1 or 2 hydrogens, more preferably 1 hydrogen, on the atom or radical indicated in the expression using “substituted” are replaced with a selection from the indicated group, provided that the normal valency is not exceeded, and that the substitution results in a chemically stable compound, i.e. a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into a therapeutic agent. 
     Combinations of substituents and/or variables are permissible only if such combinations result in chemically stable compounds. “Stable compound” is meant to indicate a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into a therapeutic agent. 
     C(O) or C(═O) represents a carbonyl moiety. 
     S(O) 2  or SO 2  represents a sulfonyl moiety. 
     Substituents covered by the term “Het x ” (where x is an integer; or Het x  refers to Het 1a , Het 1b , Het 2a , . . . ), “heterocyclyl” or “heteroaryl” may be attached to the remainder of the molecule of Formula (I) through any available ring carbon or heteroatom as appropriate, if not otherwise specified. 
     Whenever substituents are represented by chemical structure, “---” represents the bond of attachment to the remainder of the molecule of Formula (I). 
     When any variable occurs more than one time in any constituent, each definition is independent. 
     When any variable occurs more than one time in any formula (e.g. Formula (I)), each definition is independent. 
     The term “subject” as used herein, refers to an animal, preferably a mammal (e.g. cat, dog, primate or human), more preferably a human, who is or has been the object of treatment, observation or experiment. 
     The term “therapeutically effective amount” as used herein, means that amount of active compound or pharmaceutical agent that elicits the biological or medicinal response in a tissue system, animal or human that is being sought by a researcher, veterinarian, medicinal doctor or other clinician, which includes alleviation or reversal of the symptoms of the disease or disorder being treated. 
     The term “composition” is intended to encompass a product comprising the specified ingredients in the specified amounts, as well as any product which results, directly or indirectly, from combinations of the specified ingredients in the specified amounts. 
     The term “treatment”, as used herein, is intended to refer to all processes wherein there may be a slowing, interrupting, arresting or stopping of the progression of a disease, but does not necessarily indicate a total elimination of all symptoms. 
     The term “compound(s) of the (present) invention” or “compound(s) according to the (present) invention” as used herein, is meant to include the compounds of Formula (I) and the pharmaceutically acceptable salts, and the solvates thereof. 
     As used herein, any chemical formula with bonds shown only as solid lines and not as solid wedged or hashed wedged bonds, or otherwise indicated as having a particular configuration (e.g. R, S) around one or more atoms, contemplates each possible stereoisomer, or mixture of two or more stereoisomers. 
     Hereinbefore and hereinafter, the term “compound(s) of Formula (I)” is meant to include the tautomers thereof and the stereoisomeric forms thereof. 
     The terms “stereoisomers”, “stereoisomeric forms” or “stereochemically isomeric forms” hereinbefore or hereinafter are used interchangeably. 
     The invention includes all stereoisomers of the compounds of the invention either as a pure stereoisomer or as a mixture of two or more stereoisomers. 
     Enantiomers are stereoisomers that are non-superimposable mirror images of each other. A 1:1 mixture of a pair of enantiomers is a racemate or racemic mixture. 
     Atropisomers (or atropoisomers) are stereoisomers which have a particular spatial configuration, resulting from a restricted rotation about a single bond, due to large steric hindrance. All atropisomeric forms of the compounds of Formula (I) are intended to be included within the scope of the present invention. 
     Diastereomers (or diastereoisomers) are stereoisomers that are not enantiomers, i.e. they are not related as mirror images. If a compound contains a double bond, the substituents may be in the E or the Z configuration. 
     Substituents on bivalent cyclic (partially) saturated radicals may have either the cis- or trans-configuration; for example if a compound contains a disubstituted cycloalkyl group, the substituents may be in the cis or trans configuration. 
     Therefore, the invention includes enantiomers, atropisomers, diastereomers, racemates, E isomers, Z isomers, cis isomers, trans isomers and mixtures thereof, whenever chemically possible. 
     The meaning of all those terms, i.e. enantiomers, atropisomers, diastereomers, racemates, E isomers, Z isomers, cis isomers, trans isomers and mixtures thereof are known to the skilled person. 
     The absolute configuration is specified according to the Cahn-Ingold-Prelog system. The configuration at an asymmetric atom is specified by either R or S. Resolved stereoisomers whose absolute configuration is not known can be designated by (+) or (−) depending on the direction in which they rotate plane polarized light. For instance, resolved enantiomers whose absolute configuration is not known can be designated by (+) or (−) depending on the direction in which they rotate plane polarized light. 
     When a specific stereoisomer is identified, this means that said stereoisomer is substantially free, i.e. associated with less than 50%, preferably less than 20%, more preferably less than 10%, even more preferably less than 5%, in particular less than 2% and most preferably less than 1%, of the other stereoisomers. Thus, when a compound of Formula (I) is for instance specified as (R), this means that the compound is substantially free of the (S) isomer; when a compound of Formula (I) is for instance specified as E, this means that the compound is substantially free of the Z isomer; when a compound of Formula (I) is for instance specified as cis, this means that the compound is substantially free of the trans isomer. 
     Some of the compounds according to Formula (I) may also exist in their tautomeric form. Such forms in so far as they may exist, although not explicitly indicated in the above Formula (I) are intended to be included within the scope of the present invention. It follows that a single compound may exist in both stereoisomeric and tautomeric form. 
     For use in medicine, the salts of the compounds of this invention refer to non-toxic “pharmaceutically acceptable salts”. Other salts may, however, be useful in the preparation of compounds according to this invention or of their pharmaceutically acceptable salts. Suitable pharmaceutically acceptable salts of the compounds include acid addition salts which may, for example, be formed by mixing a solution of the compound with a solution of a pharmaceutically acceptable acid such as hydrochloric acid, sulfuric acid, fumaric acid, maleic acid, succinic acid, acetic acid, benzoic acid, citric acid, tartaric acid, carbonic acid or phosphoric acid. 
     Conversely, said salt forms can be converted into the free base form by treatment with an appropriate base. 
     Furthermore, where the compounds of the invention carry an acidic moiety, suitable pharmaceutically acceptable salts thereof may include alkali metal salts, e.g., sodium or potassium salts; alkaline earth metal salts, e.g., calcium or magnesium salts; and salts formed with suitable organic ligands, e.g., quaternary ammonium salts. 
     Representative acids which may be used in the preparation of pharmaceutically acceptable salts include, but are not limited to, the following: acetic acid, 2,2-dichloroactic acid, acylated amino acids, adipic acid, alginic acid, ascorbic acid, L-aspartic acid, benzenesulfonic acid, benzoic acid, 4-acetamidobenzoic acid, (+)-camphoric acid, camphorsulfonic acid, capric acid, caproic acid, caprylic acid, cinnamic acid, citric acid, cyclamic acid, ethane-1,2-disulfonic acid, ethanesulfonic acid, 2-hydroxy-ethanesulfonic acid, formic acid, fumaric acid, galactaric acid, gentisic acid, glucoheptonic acid, D-gluconic acid, D-glucoronic acid, L-glutamic acid, beta-oxo-glutaric acid, glycolic acid, hippuric acid, hydrobromic acid, hydrochloric acid, (+)-L-lactic acid, (±)-DL-lactic acid, lactobionic acid, maleic acid, (−)-L-malic acid, malonic acid, (±)-DL-mandelic acid, methanesulfonic acid, naphthalene-2-sulfonic acid, naphthalene-1,5-disulfonic acid, 1-hydroxy-2-naphthoic acid, nicotinic acid, nitric acid, oleic acid, orotic acid, oxalic acid, palmitic acid, pamoic acid, phosphoric acid, L-pyroglutamic acid, salicylic acid, 4-amino-salicylic acid, sebacic acid, stearic acid, succinic acid, sulfuric acid, tannic acid, (+)-L-tartaric acid, thiocyanic acid, p-toluenesulfonic acid, trifluoromethylsulfonic acid, and undecylenic acid. 
     Representative bases which may be used in the preparation of pharmaceutically acceptable salts include, but are not limited to, the following: ammonia, L-arginine, benethamine, benzathine, calcium hydroxide, choline, dimethylethanolamine, diethanolamine, diethylamine, 2-(diethylamino)-ethanol, ethanolamine, ethylene-diamine, N-methyl-glucamine, hydrabamine, 1H-imidazole, L-lysine, magnesium hydroxide, 4-(2-hydroxyethyl)-morpholine, piperazine, potassium hydroxide, 1-(2-hydroxyethyl)-pyrrolidine, secondary amine, sodium hydroxide, triethanolamine, tromethamine and zinc hydroxide. 
     Conversely, said salt forms can be converted into the free acid forms by treatment with an appropriate acid. 
     The term solvate comprises the solvent addition forms as well as the salts thereof, which the compounds of Formula (I) are able to form. Examples of such solvent addition forms are e.g. hydrates, alcoholates and the like. 
     In the framework of this application, an element, in particular when mentioned in relation to a compound according to Formula (I), comprises all isotopes and isotopic mixtures of this element, either naturally occurring or synthetically produced, either with natural abundance or in an isotopically enriched form. Radiolabelled compounds of Formula (I) may comprise a radioactive isotope selected from the group of  2 H (D),  3 H,  11 C,  18 F,  122 I,  123 I,  125 I,  131 I,  75 Br,  76 Br,  77 Br and  82 Br. Preferably, the radioactive isotope is selected from the group of  2 H,  3 H,  11 C and  18 F. More preferably, the radioactive isotope is  2 H. In particular, deuterated compounds are intended to be included within the scope of the present invention. 
     The present invention relates in particular to compounds of Formula (I) as defined herein, and tautomers and stereoisomeric forms thereof, wherein
     R 0  is selected from the group of hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl and C 1-4 alkyl substituted with one —OC 1-4 alkyl;   Het is a bicyclic heterocyclic radical selected from (a-1) and (a-2);   R 1a  is selected from the group of C 1-4 alkyl; and C 1-4 alkyl substituted with one or more fluoro substituents;   R 2a  is selected from the group of C 1-4 alkyl; C 1-4 alkyl substituted with one or more fluoro substituents; C 3-6 cycloalkyl; and Het 1a ;   or R 1a  and R 2a  together with the carbon atom to which they are attached form a C 3-6 cycloalkyl;   R 1b  is selected from the group of C 1-4 alkyl; and C 1-4 alkyl substituted with one or more fluoro substituents;   R 2b  is selected from the group of C 1-4 alkyl; C 1-4 alkyl substituted with one or more fluoro substituents; C 3-6 cycloalkyl; and Het 1b ;   or R 1b  and R 2b  together with the carbon atom to which they are attached form a C 3-6 cycloalkyl;   Het 1a  is a heteroaryl selected from the group of thienyl, thiazolyl, pyrrolyl, oxazolyl, oxadiazolyl, pyrazolyl, imidazolyl, isoxazolyl, and isothiazolyl, each of which may be optionally substituted with one or two substituents independently selected from halogen, cyano, C 1-4 alkyl, C 1-4 alkyloxy, C 1-4 alkyl substituted with one or more fluoro substituents, and C 1-4 alkyloxy substituted with one or more fluoro substituents;   Het 1b  is a heteroaryl selected from the group of thienyl, thiazolyl, pyrrolyl, oxazolyl, oxadiazolyl, pyrazolyl, imidazolyl, isoxazolyl, and isothiazolyl, each of which may be optionally substituted with one or two substituents independently selected from halogen, cyano, C 1-4 alkyl, C 1-4 alkyloxy, C 1-4 alkyl substituted with one or more fluoro substituents, and C 1-4 alkyloxy substituted with one or more fluoro substituents;   R 3a  is hydrogen;   R 3b  is hydrogen;   R 4a  and R 4b  are hydrogen;   R 5  is hydrogen;   R 6  is hydrogen;   R 7  is selected from the group of hydrogen; Het 2a ; R 10a ; C 1-6 alkyl optionally substituted with one Het 3a ; and C 2-6 alkyl substituted with one or more substituents independently selected from the group of fluoro, —NR 7a R 7b , and —OR 7c ;   R 7a , R 7b  and R 7c  are each independently selected from hydrogen and C 1-6 alkyl;   Het 2a  is a heterocyclyl, bound through any available carbon atom, selected from the group of piperidinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl,   C 1-4 alkyl substituted with one —OC 1-4 alkyl,   C 1-4 alkyl substituted with one C 3-6 cycloalkyl,   and C 1-4 alkyl substituted with one or more fluoro substituents;   Het 3a  is a heterocyclyl selected from the group of morpholinyl, piperidinyl, piperazinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl,   C 1-4 alkyl substituted with one —OC 1-4 alkyl,   C 1-4 alkyl substituted with one C 3-6 cycloalkyl,   and C 1-4 alkyl substituted with one or more fluoro substituents;   R 10a  is C 3-6 cycloalkyl optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 1-4 alkyl substituted with one —OC 1-4 alkyl, and C 1-4 alkyl substituted with one or more fluoro substituents;   R 8  is selected from the group of hydrogen; Het 2b ; R 10b ; halogen; cyano; —NR 8a R 8b ; and C 1-6 alkyl optionally substituted with one or more substituents independently selected from the group of fluoro, —NR 8a R 8b , —OR 8c , - and Het 3b ;   R 8a , R 8b  and R 8c  are each independently selected from the group of hydrogen and C 1-6 alkyl;   Het 2b  is a heterocyclyl selected from the group of morpholinyl, piperidinyl, piperazinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl,   C 1-4 alkyl substituted with one —OC 1-4 alkyl,   C 1-4 alkyl substituted with one C 3-6 cycloalkyl,   and C 1-4 alkyl substituted with one or more fluoro substituents;   Het 3b  is a heterocyclyl selected from the group of morpholinyl, piperidinyl, piperazinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl,   C 1-4 alkyl substituted with one —OC 1-4 alkyl,   C 1-4 alkyl substituted with one C 3-6 cycloalkyl,   and C 1-4 alkyl substituted with one or more fluoro substituents;   R 10b  is C 3-6 cycloalkyl optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 1-4 alkyl substituted with one —OC 1-4 alkyl, and C 1-4 alkyl substituted with one or more fluoro substituents;   and the pharmaceutically acceptable salts, and the solvates thereof.   

     The present invention relates in particular to compounds of Formula (I) as defined herein, and tautomers and stereoisomeric forms thereof, wherein
     R 0  is hydrogen;   Het is a bicyclic heterocyclic radical selected from (a-1) and (a-2);   R 1a  is selected from the group of C 1-4 alkyl and C 3-6 cycloalkyl;   R 2a  is selected from the group of C 1-4 alkyl and C 3-6 cycloalkyl;   R 1b  is C 1-4 alkyl;   R 2b  is C 1-4 alkyl;   R 3a  is hydrogen;   R 3b  is hydrogen;   R 4a  and R 4b  are hydrogen;   R 5  is hydrogen;   R 6  is hydrogen;   R 7  is selected from the group of hydrogen; Het 2a ; C 1-6 alkyl optionally substituted with one Het 3a ; and C 2-6 alkyl substituted with one —OR 7C ;   R 7c  is selected from hydrogen and C 1-6 alkyl;   Het 2a  is a heterocyclyl, bound through any available carbon atom, selected from the group of piperidinyl, pyrrolidinyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from C 1-4 alkyl and C 3-6 cycloalkyl;   Het 3a  is a pyrrolidinyl which may be optionally substituted with one or two C 1-4 alkyl substituents;   R 8  is selected from the group of hydrogen; Het 2b ; C 1-6 alkyl optionally substituted with Het 3a ; and C 1-6 alkyl substituted with one —OR 8c ;   R 8c  is selected from the group of hydrogen and C 1-6 alkyl;   Het 2b  is a heterocyclyl selected from the group of piperidinyl, pyrrolidinyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from C 1-4 alkyl and C 3-6 cycloalkyl;   Het 3b  is a pyrrolidinyl which may be optionally substituted with one or two C 1-4 alkyl substituents;   and the pharmaceutically acceptable salts, and the solvates thereof.   

     The present invention relates in particular to compounds of Formula (I) as defined herein, and tautomers and stereoisomeric forms thereof, wherein
     R 0  is hydrogen;   Het is a bicyclic heterocyclic radical selected from (a-1) and (a-2);   R 1a  is C 1-4 alkyl;   R 2a  is selected from the group of C 1-4 alkyl and C 3-6 cycloalkyl;   R 1b  is C 1-4 alkyl;   R 2b  is C 1-4 alkyl;   R 3a  is hydrogen;   R 3b  is hydrogen;   R 4a  and R 4b  are hydrogen;   R 5  is hydrogen;   R 6  is hydrogen;   R 7  is selected from the group of Het 2a ; C 1-6 alkyl optionally substituted with one Het 3a ; and C 2-6 alkyl substituted with one —OR 7c ;   R 7c  is selected from hydrogen and C 1-6 alkyl;   Het 2a  is a heterocyclyl, bound through any available carbon atom, selected from the group of piperidinyl, pyrrolidinyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from C 1-4 alkyl and C 3-6 cycloalkyl;   Het 3a  is a pyrrolidinyl which may be optionally substituted with one or two C 1-4 alkyl substituents;   R 8  is selected from the group of hydrogen; Het 2b ; and C 1-6 alkyl optionally substituted with one —OR 8c ;   R 8c  is selected from the group of hydrogen and C 1-6 alkyl;   Het 2b  is piperidinyl which may be optionally substituted with one or two C 1-4 alkyl substituents;   and the pharmaceutically acceptable salts, and the solvates thereof.   

     The present invention relates in particular to compounds of Formula (I) as defined herein, and tautomers and stereoisomeric forms thereof, wherein
     R 0  is selected from the group of hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl and C 1-4 alkyl substituted with one —OC 1-4 alkyl;   Het is bicyclic heterocyclic (a-1);   R 1a  is selected from the group of hydrogen; C 1-4 alkyl; and C 1-4 alkyl substituted with one or more fluoro substituents;   R 2a  is selected from the group of hydrogen; C 1-4 alkyl; C 1-4 alkyl substituted with one or more fluoro substituents; C 3-6 cycloalkyl; and Het 1a ;   or R 1a  and R 2a  together with the carbon atom to which they are attached form a C 3-6 cycloalkyl;   Het 1a  is a heteroaryl selected from the group of thienyl, thiazolyl, pyrrolyl, oxazolyl, oxadiazolyl, pyrazolyl, imidazolyl, isoxazolyl, and isothiazolyl, each of which may be optionally substituted with one or two substituents independently selected from halogen, cyano, C 1-4 alkyl, C 1-4 alkyloxy, C 1-4 alkyl substituted with one or more fluoro substituents, and C 1-4 alkyloxy substituted with one or more fluoro substituents;   R 3a  is selected from the group of hydrogen; halogen; cyano; C 3-6 cycloalkyl; C 1-6 alkyl;   Het 4a ; C 1-6 alkyl substituted with one or more fluoro substituents; —OC 1-6 alkyl; —OC 1-6 alkyl substituted with one or more fluoro substituents; and C 1-6 alkyl substituted with one substituent selected from —NR 3aa R 3ab  and —OC 1-4 alkyl;   Het 4a  is a heteroaryl selected from the group of piperidinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl, piperazinyl, morpholinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl and C 3-6 cycloalkyl;   R 3aa  and R 3ab  are each independently selected from hydrogen and C 1-4 alkyl;   R 4a  is hydrogen;   R 5  is selected from the group of hydrogen; cyano; C 1-4 alkyl; C 1-4 alkyl substituted with one or more fluoro substituents; C 1-4 alkyl substituted with one substituent selected from the group of —NR 5a R 5b , —OC 1-4 alkyl, and Het 5 ;   R 5a  and R 5b  are each independently selected from the group of hydrogen and C 1-4 alkyl;   Het 5  is a heterocyclyl selected from the group of piperidinyl, piperazinyl, morpholinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl and C 1-4 alkyl substituted with one or more fluoro substituents;   R 7  is selected from the group of hydrogen; Het 2a ; R 10a ; C 1-6 alkyl optionally substituted with one Het 3a ; and C 2-6 alkyl substituted with one or more substituents independently selected from the group of fluoro, —NR 7a R 7b , and —OR 7c ;   R 7a , R 7b  and R 7c  are each independently selected from hydrogen and C 1-6 alkyl;   Het 2a  is a heterocyclyl, bound through any available carbon atom, selected from the group of piperidinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl,   C 1-4 alkyl substituted with one —OC 1-4 alkyl,   C 1-4 alkyl substituted with one C 3-6 cycloalkyl,   and C 1-4 alkyl substituted with one or more fluoro substituents;   Het 3a  is a heterocyclyl selected from the group of morpholinyl, piperidinyl, piperazinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl,   C 1-4 alkyl substituted with one —OC 1-4 alkyl,   C 1-4 alkyl substituted with one C 3-6 cycloalkyl,   and C 1-4 alkyl substituted with one or more fluoro substituents;   R 10a  is C 3-6 cycloalkyl optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 1-4 alkyl substituted with one —OC 1-4 alkyl,   and C 1-4 alkyl substituted with one or more fluoro substituents;   and the pharmaceutically acceptable salts, and the solvates thereof.   

     The present invention relates in particular to compounds of Formula (I) as defined herein, and tautomers and stereoisomeric forms thereof, wherein
     R 0  is selected from the group of hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl and C 1-4 alkyl substituted with one —OC 1-4 alkyl;   Het is a bicyclic heterocyclic (a-2);   R 1b  is selected from the group of hydrogen; C 1-4 alkyl; and C 1-4 alkyl substituted with one or more fluoro substituents;   R 2b  is selected from the group of hydrogen; C 1-4 alkyl; C 1-4 alkyl substituted with one or more fluoro substituents; C 3-6 cycloalkyl; and Het 1b ;   or R 1b  and R 2b  together with the carbon atom to which they are attached form a C 3-6 cycloalkyl;   Het 1b  is a heteroaryl selected from the group of thienyl, thiazolyl, pyrrolyl, oxazolyl, oxadiazolyl, pyrazolyl, imidazolyl, isoxazolyl, and isothiazolyl, each of which may be optionally substituted with one or two substituents independently selected from halogen, cyano, C 1-4 alkyl, C 1-4 alkyloxy, C 1-4 alkyl substituted with one or more fluoro substituents, and C 1-4 alkyloxy substituted with one or more fluoro substituents;   R 3b  is selected from the group of hydrogen; halogen; cyano; C 3-6 cycloalkyl; C 1-6 alkyl;   Het 4b ; C 1-6 alkyl substituted with one or more fluoro substituents; —OC 1-6 alkyl; —OC 1-6 alkyl substituted with one or more fluoro substituents; and C 1-6 alkyl substituted with one substituent selected from —NR 3ba R 3bb  and —OC 1-4 alkyl;   Het 4b  is a heteroaryl selected from the group of piperidinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl, piperazinyl, morpholinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl and C 3-6 cycloalkyl;   R 3ba  and R 3bb  are each independently selected from hydrogen and C 1-4 alkyl;   R 4b  is hydrogen;   R 6  is selected from the group of hydrogen; cyano; C 1-4 alkyl; C 1-4 alkyl substituted with one or more fluoro substituents; C 1-4 alkyl substituted with one substituent selected from the group of —NR 6a R 6b , —OC 1-4 alkyl, and Het 6 ;   R 6a  and R 6b  are each independently selected from the group of hydrogen and C 1-4 alkyl;   Het 6  is a heterocyclyl selected from the group of piperidinyl, piperazinyl, morpholinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl and C 1-4 alkyl substituted with one or more fluoro substituents;   R 8  is selected from the group of hydrogen; Het 2b ; R 10b ; halogen; cyano; —NR 8a R 8b ; and C 1-6 alkyl optionally substituted with one or more substituents independently selected from the group of fluoro, —NR 8a R 8b , —OR 8c , - and Het 3b ;   R 8a , R 8b  and R 8c  are each independently selected from the group of hydrogen and C 1-6 alkyl;   Het 2b  is a heterocyclyl selected from the group of morpholinyl, piperidinyl, piperazinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl,   C 1-4 alkyl substituted with one —OC 1-4 alkyl,   C 1-4 alkyl substituted with one C 3-6 cycloalkyl,   and C 1-4 alkyl substituted with one or more fluoro substituents;   Het 3b  is a heterocyclyl selected from the group of morpholinyl, piperidinyl, piperazinyl, tetrahydropyranyl, pyrrolidinyl, tetrahydrofuranyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 3-6 cycloalkyl,   C 1-4 alkyl substituted with one —OC 1-4 alkyl,   C 1-4 alkyl substituted with one C 3-6 cycloalkyl,   and C 1-4 alkyl substituted with one or more fluoro substituents;   R 10b  is C 3-6 cycloalkyl optionally substituted with one or two substituents independently selected from fluoro, C 1-4 alkyl, —OC 1-4 alkyl, C 1-4 alkyl substituted with one —OC 1-4 alkyl, and C 1-4 alkyl substituted with one or more fluoro substituents;   and the pharmaceutically acceptable salts, and the solvates thereof.   

     Another embodiment of the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments wherein one or more of the following restrictions apply:
     (a) R 0  is hydrogen;   (b) Het is a bicyclic heterocyclic radical selected from (a-1) and (a-2);   (c) R 1a  is C 1-4 alkyl;   (d) R 2a  is selected from the group of C 1-4 alkyl and C 3-6 cycloalkyl;   (e) R 1b  is C 1-4 alkyl;   (f) R 2b  is C 1-4 alkyl;   (g) R 3a  is hydrogen;   (h) R 3b  is hydrogen;   (i) R 4a  and R 4b  are hydrogen;   (j) R 5  is hydrogen;   (k) R 6  is hydrogen;   (l) R 7  is selected from the group of Het 2a ; C 1-6 alkyl optionally substituted with one Het 3a ; and C 2-6 alkyl substituted with one —OR 7c ;   (m) R 7c  is selected from hydrogen and C 1-6 alkyl;   (n) Het 2a  is a heterocyclyl, bound through any available carbon atom, selected from the group of piperidinyl, pyrrolidinyl, azetidinyl and oxetanyl, each of which may be optionally substituted with one or two substituents independently selected from C 1-4 alkyl and C 3-6 cycloalkyl;   (o) Het 3a  is a pyrrolidinyl which may be optionally substituted with one or two C 1-4 alkyl substituents;   (p) R 8  is selected from the group of hydrogen; Het 2b ; and C 1-6 alkyl optionally substituted with one —OR 8c ;   (q) R 8c  is selected from the group of hydrogen and C 1-6 alkyl;   (r) Het 2b  is piperidinyl which may be optionally substituted with one or two C 1-4 alkyl substituents.   

     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein 
     Het 1a  is a heteroaryl selected from the group of thienyl, thiazolyl, pyrrolyl, oxazolyl, oxadiazolyl, pyrazolyl, imidazolyl, isoxazolyl, and isothiazolyl, each of which may be optionally substituted with one or two substituents independently selected from halogen, cyano, C 1-4 alkyl, C 1-4 alkyloxy, C 1-4 alkyl substituted with one or more fluoro substituents, and C 1-4 alkyloxy substituted with one or more fluoro substituents; 
     Het 1b  is a heteroaryl selected from the group of thienyl, thiazolyl, pyrrolyl, oxazolyl, oxadiazolyl, pyrazolyl, imidazolyl, isoxazolyl, and isothiazolyl, each of which may be optionally substituted with one or two substituents independently selected from halogen, cyano, C 1-4 alkyl, C 1-4 alkyloxy, C 1-4 alkyl substituted with one or more fluoro substituents, and C 1-4 alkyloxy substituted with one or more fluoro substituents. 
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein Het is (a-1). 
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein Het is (a-2). 
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein
     R 1a  is selected from the group of hydrogen; C 1-4 alkyl; and C 1-4 alkyl substituted with one or more fluoro substituents;   R 2a  is selected from the group of hydrogen; C 1-4 alkyl; C 1-4 alkyl substituted with one or more fluoro substituents; C 3-6 cycloalkyl; and Het 1a ;   R 1b  is selected from the group of hydrogen; C 1-4 alkyl; and C 1-4 alkyl substituted with one or more fluoro substituents;   R 2b  is selected from the group of hydrogen; C 1-4 alkyl; C 1-4 alkyl substituted with one or more fluoro substituents; C 3-6 cycloalkyl; and Het 1b .   

     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein
     R 1a  and R 2a  together with the carbon atom to which they are attached form a C 3-6 cycloalkyl;   R 1b  and R 2b  together with the carbon atom to which they are attached form a C 3-6 cycloalkyl.   

     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein
     R 1a  is selected from the group of C 1-4 alkyl; and C 1-4 alkyl substituted with one or more fluoro substituents;   R 2a  is selected from the group of C 1-4 alkyl; C 1-4 alkyl substituted with one or more fluoro substituents; C 3-6 cycloalkyl; and Het 1a .   

     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein R 1a  and R 2a  together with the carbon atom to which they are attached form a C 3-6 cycloalkyl. 
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein
     R 1b  is selected from the group of C 1-4 alkyl; and C 1-4 alkyl substituted with one or more fluoro substituents;   R 2b  is selected from the group of C 1-4 alkyl; C 1-4 alkyl substituted with one or more fluoro substituents; C 3-6 cycloalkyl; and Het 1b .   

     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein R 1b  and R 2b  together with the carbon atom to which they are attached form a C 3-6 cycloalkyl. 
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein R 0  is hydrogen. 
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein
     R 0  is hydrogen;   R 3a  is hydrogen;   R 3b  is hydrogen;   R 4a  and R 4b  are hydrogen;   R 5  is hydrogen;   R 6  is hydrogen.   

     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein R 7c  is C 1-6 alkyl; in particular methyl. 
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein R 8c  is C 1-6 alkyl; in particular methyl. 
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein R 7c  and R 8c  are C 1-6 alkyl; in particular methyl. 
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein Het 3a  is a heterocyclyl, bound through any available carbon atom. 
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein
     R 7  is selected from the group of hydrogen, —CH(CH 3 ) 2 ,   

                         
and wherein R 8  is selected from the group of hydrogen, —CH(CH 3 ) 2 ,
 
     
       
         
         
             
             
         
       
     
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein
     R 7  is selected from the group of   

                         
and wherein R 8  is selected from the group of hydrogen, —CH(CH 3 ) 2 ,
 
     
       
         
         
             
             
         
       
     
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein Het is (a-1) and R 7  is selected from the group of 
     
       
         
         
             
             
         
       
     
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein Het is (a-2) and R 8  is selected from the group of hydrogen, —CH(CH 3 ) 2 , 
     
       
         
         
             
             
         
       
     
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein
     R 7  is selected from the group of hydrogen, —CH(CH 3 ) 2 ,   

                         
and wherein R 8  is selected from the group of hydrogen, —C(CH 3 ) 2 ,
 
     
       
         
         
             
             
         
       
     
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein Het is (a-1) and R 7  is selected from the group of hydrogen, —CH(CH 3 ) 2 , 
     
       
         
         
             
             
         
       
     
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof, or any subgroup thereof as mentioned in any of the other embodiments, wherein Het is (a-2) and R 8  is selected from the group of hydrogen, —CH(CH 3 ) 2 , 
     
       
         
         
             
             
         
       
     
     In an embodiment, the present invention relates to those compounds of Formula (I) and the pharmaceutically acceptable addition salts, and the solvates thereof or any subgroup thereof as mentioned in any of the other embodiments, wherein R 7  and R 8  are other than hydrogen. 
     Specific compounds according to the invention include: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
         
         tautomers and stereoisomeric forms thereof, 
         and the pharmaceutically acceptable salts, and the solvates thereof. 
       
    
     METHODS OF SYNTHESIS 
     Compounds of Formula (I) can be prepared by methods known to those who are skilled in the art. The following schemes are only meant to represent examples of the invention and are in no way meant to be a limit of the invention. 
     Herein, the term ‘DCM’ means dichloromethane, ‘DMF’ means N,N-dimethylformamide, ‘MeOH’ means methanol, ‘EtOH’ means ethanol, ‘NMP’ means N-methyl-2-pyrrolidone, ‘Et 3 N’ means triethylamine, ‘Pd(PPh 3 ) 4 ’ means tetrakis(triphenylphosphine)palladium, ‘BOC’ means tert-butoxycarbonyl, ‘TFA’ means trifluoroacetic acid and ‘i-Pr’ means isopropyl. 
     
       
         
         
             
             
         
       
     
     Scheme 1 illustrates methods of preparing compounds of Formula (I) wherein Het is (a-1), hereby named compounds of Formula (Ia-1), wherein R 1a , R 2a , R 3a , R 4a , R 5  and R 7  are as defined in Formula (I). Intermediates of Formula IIa and IIb, wherein X is a suitable leaving group such as halogen or triflate, can be reacted with alkynes of Formula IIIa under palladium-catalyzed Sonogashira coupling conditions, using for example Pd(PPh 3 ) 4 , CuI and a base such as Et 3 N in acetonitrile, with heating, to furnish compounds of Formula (Ia-1). Alkynes of Formula IIIa are commercially available or can be prepared by known methods. 
     
       
         
         
             
             
         
       
     
     Scheme 2 illustrates methods of preparing intermediates of Formula IIa wherein R 3a , R 4a  and R 5  are as defined in Formula (I), R 7  is other than hydrogen, and X is as defined above. Treatment of azaindoles of Formula IV with a suitable electrophile under basic conditions, such as R 7 -LG, wherein LG is a leaving group such as halogen, mesylate or triflate, using for instance, cesium carbonate in DMF under heating, yields N-substituted azaindoles of Formula V. Intermediates of Formula V can be reacted with 3,4,5-trimethoxybenzylamine under basic conditions, for example employing pyridine in a suitable solvent such as NMP with heating, to yield benzylamines of Formula VI. The 3,4,5-trimethoxybenzyl group can then be removed under suitable conditions, for example employing TFA with heating to furnish intermediates of Formula IIa. 
     
       
         
         
             
             
         
       
     
     Scheme 3 illustrates methods of preparing intermediates of Formula IIb wherein R 3a , R 4a  and R 5  are as defined in Formula (I), R 7  is hydrogen and X is as defined above. Intermediates of Formula IV can be reacted with 3,4,5-trimethoxybenzylamine under basic conditions, for example employing pyridine in a suitable solvent such as NMP with heating, to yield benzylamines of Formula VII. The 3,4,5-trimethoxybenzyl group can then be removed under suitable conditions, for example employing TFA with heating to furnish intermediates IIb. 
     
       
         
         
             
             
         
       
     
     Scheme 4 illustrates alternative methods of preparing intermediates of Formula IIa wherein R 3a , R 4a , and R 5  are as defined in Formula (I), R 7  is other than hydrogen, and X is as defined above. Treatment of intermediates of Formula IIb with a suitable electrophile under basic conditions, such as R 7 -LG, wherein LG is a leaving group such as halogen, mesylate or triflate, using for instance, cesium carbonate in DMF under heating, yields intermediates IIa. 
     
       
         
         
             
             
         
       
     
     Scheme 5 illustrates alternative methods of preparing intermediates of Formula IIa wherein R 3a , R 4a , and R 5  are as defined in Formula (I), R 7  is other than hydrogen, and X is as defined above. Intermediates of Formula VII can be N-functionalised by treatment with a suitable electrophile under basic conditions, such as R 7 -LG, wherein LG is a leaving group such as halogen, mesylate or triflate, using for instance, cesium carbonate in DMF under heating, to give intermediates of Formula VI. The 3,4,5-trimethoxybenzyl group can then be removed under suitable conditions, for example employing TFA with heating to furnish intermediates of Formula IIa. 
     Additional intermediates of formula IIa, V and VI can be prepared by elaboration of functional groups present at R 7 . Such elaboration includes, but is not limited to, hydrolysis, reduction, oxidation, alkylation, amidation and dehydration. 
     
       
         
         
             
             
         
       
     
     Scheme 6 illustrates methods of preparing intermediates of Formula IV wherein R 3a , R 4a  and R 5  are as defined in Formula (I) and X is as defined above. Protection of an azaindole of Formula VIII with a suitable protecting group such as BOC furnishes an intermediate of Formula IX. An intermediate of Formula IX can be reacted with 2,4-dichlorothieno[3,2-d]pyrimidine under palladium-catalyzed Stille coupling conditions, using for example hexamethylditin and Pd(PPh 3 ) 4  in 1,4-dioxane, with heating, to furnish an intermediate of Formula IV. 
     
       
         
         
             
             
         
       
     
     Scheme 7 illustrates methods of preparing compounds of Formula (I) wherein Het is (a-2), hereby named compounds of Formula (Ia-2), wherein R 1b , R 2b , R 3b , R 4b , R 6  and R 8  are as defined in Formula (I). Azaindoles of Formula Xa wherein X is a suitable leaving group such as halogen or triflate, can be reacted with 2,4-dichlorothieno[3,2-d]pyrimidine under basic conditions, using for example NaH in DMF to give intermediates of Formula XI. Intermediates of Formula XI can be reacted with 3,4,5-trimethoxybenzylamine under basic conditions, for example employing pyridine in a suitable solvent such as NMP with heating, to yield benzylamines of Formula XII. The 3,4,5-trimethoxybenzyl group can then be removed under suitable conditions, for example employing TFA with heating to furnish intermediates of Formula XIII. Compounds of Formula (Ia-2) are then furnished by palladium-catalysed Sonogashira coupling with alkynes of Formula IIIb, as described above for the transformation of intermediates of Formula IIa and IIb into compounds of Formula (Ia-1). Alkynes of Formula IIIb are commercially available or can be prepared by known methods. 
     
       
         
         
             
             
         
       
     
     Scheme 8 illustrates alternative methods for preparing compounds of Formula (Ia-2) wherein R 1b , R 2b , R 3b , R 4b , R 6  and R 8  are as defined in Formula (I). Intermediates of Formula XI can be reacted with alkynes of Formula IIIb under palladium-catalysed Sonogashira coupling conditions, using for example Pd(PPh 3 ) 4 , CuI and a base such as Et 3 N in acetonitrile, with heating, to furnish intermediates of formula XIV. Büchwald-Hartwig amination of intermediates of Formula XIV, using a suitably protected nitrogen species such as carbamic acid tert-butyl ester in an appropriate solvent such as 1,4-dioxane gives intermediates of Formula XV. Removal of the protecting group under suitable conditions such as employing TFA in DCM furnishes compounds of Formula (Ia-2). 
     
       
         
         
             
             
         
       
     
     Scheme 9 illustrates a method for preparing intermediates of Formula Xb, wherein R 8  is N-substituted piperidin-4-yl (R a  is a substituent within the limits of the scope), X is as defined above, and all other variables are as defined in Formula (I). Azaindoles of Formula XVI can be alkylated with N-substituted piperidinones under basic conditions, for example employing potassium hydroxide, in a suitable solvent such as MeOH, with heating, to yield alkenes of Formula XVII. Alkenes of Formula XVII can then be hydrogenated, for example employing platinum on charcoal under a hydrogen atmosphere, in a suitable solvent such as EtOH, to yield intermediates of Formula Xb. 
     
       
         
         
             
             
         
       
     
     Scheme 10 illustrates methods of preparing intermediates of Formula Xc, wherein R b  and R c  are hydrogen or alkyl (within the limits of the scope), X is as defined above, and all other variables are as defined in Formula (I). 5-Azaindoles of Formula XVI can be converted to carbonyl intermediates of Formula XVIII by reaction with an acyl halide, anhydride or DMF. Carbonyl intermediates of Formula XVIII can be reacted with phosphonium/phosphonate ylides to give alkenes of Formula XIX, potentially as a mixture of isomers. Alkenes of Formula XIX can then be hydrogenated, for example employing platinum on charcoal under a hydrogen atmosphere, in a suitable solvent such as MeOH, to yield alkanes of Formula Xc. 
     
       
         
         
             
             
         
       
     
     Scheme 11 illustrates a method for preparing intermediates of Formula Xd, wherein R 8  is i-Pr, X is as defined above, and all other variables are as defined in Formula (I). 3-iodo-5-azaindoles of Formula XX can be protected with a suitable protecting group, such as for instance p-toluenesulfonyl, to yield azaindoles of Formula XXI. The iodo group in intermediates of Formula XXI can be reacted with isopropenylboronic acid pinacol ester under palladium-catalyzed Suzuki coupling conditions, using for example [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II)-dichloromethane complex, a base such as Cs 2 CO 3 , in a suitable solvent such as dioxane, with heating, and then hydrogenated as described above for intermediates of Formula XIX to yield intermediates of Formula Xc. 
     The method described in Scheme 11 may also be used to introduce other substituents in the R 8  position. 
     
       
         
         
             
             
         
       
     
     Scheme 12 illustrates a method for preparing intermediates of Formula Xe, wherein R 8  is —CH 2 CH 2 —R d  (R d  is a substituent within the limits of the scope), X is as defined above, and all other variables are as defined in Formula (I). The iodo group in an intermediate of Formula XXI can be reacted with alkynes under palladium-catalysed Sonogashira coupling conditions, using for example Pd(PPh 3 ) 4 , CuI and a base such as Et 3 N in acetonitrile, with heating, to furnish intermediates of Formula XXII. Hydrogenation of alkynes of Formula XXII under suitable conditions, for example employing platinum on charcoal under a hydrogen atmosphere, in a suitable solvent such as MeOH gives alkanes of Formula Xe. 
     It will be appreciated that where appropriate functional groups exist, compounds of various formulae or any intermediates used in their preparation may be further derivatised by one or more standard synthetic methods employing condensation, substitution, oxidation, reduction, or cleavage reactions. Particular substitution approaches include conventional alkylation, arylation, heteroarylation, acylation, sulfonylation, halogenation, nitration, formylation and coupling procedures. 
     The compounds of Formula (I) may be synthesized in the form of racemic mixtures of enantiomers which can be separated from one another following art-known resolution procedures. The racemic compounds of Formula (I) may be converted into the corresponding diastereomeric salt forms by reaction with a suitable chiral acid. Said diastereomeric salt forms are subsequently separated, for example, by selective or fractional crystallization and the enantiomers are liberated therefrom by alkali. An alternative manner of separating the enantiomeric forms of the compounds of Formula (I) involves liquid chromatography using a chiral stationary phase. Said pure stereochemically isomeric forms may also be derived from the corresponding pure stereochemically isomeric forms of the appropriate starting materials, provided that the reaction occurs stereospecifically. 
     In the preparation of compounds of the present invention, protection of remote functionality (e.g., primary or secondary amine) of intermediates may be necessary. The need for such protection will vary depending on the nature of the remote functionality and the conditions of the preparation methods. Suitable amino-protecting groups (NH-Pg) include acetyl, trifluoroacetyl, tert-butoxycarbonyl (BOC), benzyloxycarbonyl (CBz) and 9-fluorenylmethyleneoxycarbonyl (Fmoc). The need for such protection is readily determined by one skilled in the art. For a general description of protecting groups and their use, see T. W. Greene and P. G. M. Wuts, Protective Groups in Organic Synthesis, 4th ed., Wiley, Hoboken, N.J., 2007. 
     Compounds of the invention may be prepared from commercially available starting materials using the general methods illustrated herein. 
     Pharmacology 
     It has been found that the compounds of the present invention inhibit NF-κB-inducing kinase (NIK—also known as MAP3K14). The compounds according to the invention and the pharmaceutical compositions comprising such compounds may be useful for treating or preventing diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders. In particular, the compounds according to the present invention and the pharmaceutical compositions thereof may be useful in the treatment of a haematological malignancy or solid tumour. In a specific embodiment said haematological malignancy is selected from the group consisting of multiple myeloma, Hodgkin lymphoma, T-cell leukaemia, mucosa-associated lymphoid tissue lymphoma, diffuse large B-cell lymphoma and mantle cell lymphoma, in a particular embodiment mantle cell lymphoma. In another specific embodiment of the present invention, the solid tumour is selected from the group consisting of pancreatic cancer, breast cancer, melanoma and non-small cell lung cancer. 
     Examples of cancers which may be treated (or inhibited) include, but are not limited to, a carcinoma, for example a carcinoma of the bladder, breast, colon (e.g. colorectal carcinomas such as colon adenocarcinoma and colon adenoma), kidney, urothelial, uterus, epidermis, liver, lung (for example adenocarcinoma, small cell lung cancer and non-small cell lung carcinomas, squamous lung cancer), oesophagus, head and neck, gall bladder, ovary, pancreas (e.g. exocrine pancreatic carcinoma), stomach, gastrointestinal (also known as gastric) cancer (e.g. gastrointestinal stromal tumours), cervix, endometrium, thyroid, prostate, or skin (for example squamous cell carcinoma or dermatofibrosarcoma protuberans); pituitary cancer, a hematopoietic tumour of lymphoid lineage, for example leukemia, acute lymphocytic leukemia, chronic lymphocytic leukemia, B-cell lymphoma (e.g. diffuse large B-cell lymphoma, mantle cell lymphoma), T-cell leukaemia/lymphoma, Hodgkin&#39;s lymphoma, non-Hodgkin&#39;s lymphoma, hairy cell lymphoma, or Burkett&#39;s lymphoma; a hematopoietic tumour of myeloid lineage, for example leukemias, acute and chronic myelogenous leukemias, chronic myelomonocytic leukemia (CMML), myeloproliferative disorder, myeloproliferative syndrome, myelodysplastic syndrome, or promyelocytic leukemia; multiple myeloma; thyroid follicular cancer; hepatocellular cancer, a tumour of mesenchymal origin (e.g. Ewing&#39;s sarcoma), for example fibrosarcoma or rhabdomyosarcoma; a tumour of the central or peripheral nervous system, for example astrocytoma, neuroblastoma, glioma (such as glioblastoma multiforme) or schwannoma; melanoma; seminoma; teratocarcinoma; osteosarcoma; xeroderma pigmentosum; keratoctanthoma; thyroid follicular cancer; or Kaposi&#39;s sarcoma. 
     Hence, the invention relates to compounds of Formula (I), the tautomers and the stereoisomeric forms thereof, and the pharmaceutically acceptable salts, and the solvates thereof, for use as a medicament. 
     The invention also relates to the use of a compound of Formula (I), or a tautomer or a stereoisomeric form thereof, or a pharmaceutically acceptable salt, or a solvate thereof, or a pharmaceutical composition according to the invention, for the manufacture of a medicament. 
     The present invention also relates to a compound of Formula (I), or a tautomer or a stereoisomeric form thereof, or a pharmaceutically acceptable salt, or a solvate thereof, or a pharmaceutical composition according to the invention, for use in the treatment, prevention, amelioration, control or reduction of the risk of disorders associated with NF-κB-inducing kinase dysfunction in a mammal, including a human, the treatment or prevention of which is affected or facilitated by inhibition of NF-κB-inducing kinase. Also, the present invention relates to the use of a compound of Formula (I), or a tautomer or a stereoisomeric form thereof, or a pharmaceutically acceptable salt, or a solvate thereof, or a pharmaceutical composition according to the invention, for the manufacture of a medicament for treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with NF-κB-inducing kinase dysfunction in a mammal, including a human, the treatment or prevention of which is affected or facilitated by inhibition of NF-κB-inducing kinase. 
     The invention also relates to a compound of Formula (I), or a tautomer or a stereoisomeric form thereof, or a pharmaceutically acceptable salt, or a solvate thereof, for use in the treatment or prevention of any one of the diseases mentioned hereinbefore. 
     The invention also relates to a compound of Formula (I), or a tautomer or a stereoisomeric form thereof, or a pharmaceutically acceptable salt, or a solvate thereof, for use in treating or preventing any one of the diseases mentioned hereinbefore. 
     The invention also relates to the use of a compound of Formula (I), or a tautomer or a stereoisomeric form thereof, or a pharmaceutically acceptable salt, or a solvate thereof, for the manufacture of a medicament for the treatment or prevention of any one of the disease conditions mentioned hereinbefore. 
     The compounds of the present invention can be administered to mammals, preferably humans, for the treatment or prevention of any one of the diseases mentioned hereinbefore. 
     In view of the utility of the compounds of Formula (I), or a tautomer or a stereoisomeric form thereof, or a pharmaceutically acceptable salt, or a solvate thereof, there is provided a method of treating warm-blooded animals, including humans, suffering from any one of the diseases mentioned hereinbefore. 
     Said method comprises the administration, i.e. the systemic or topical administration, preferably oral administration, of a therapeutically effective amount of a compound of Formula (I), or a tautomer or a stereoisomeric form thereof, or a pharmaceutically acceptable salt, or a solvate thereof, to warm-blooded animals, including humans. 
     Therefore, the invention also relates to a method for the treatment of any one of the diseases mentioned hereinbefore comprising administering a therapeutically effective amount of compound according to the invention to a patient in need thereof. 
     One skilled in the art will recognize that a therapeutically effective amount of the compounds of the present invention is the amount sufficient to have therapeutic activity and that this amount varies inter alias, depending on the type of disease, the concentration of the compound in the therapeutic formulation, and the condition of the patient. Generally, the amount of a compound of the present invention to be administered as a therapeutic agent for treating the disorders referred to herein will be determined on a case by case by an attending physician. 
     Those of skill in the treatment of such diseases could determine the effective therapeutic daily amount from the test results presented hereinafter. An effective therapeutic daily amount would be from about 0.005 mg/kg to 50 mg/kg, in particular 0.01 mg/kg to 50 mg/kg body weight, more in particular from 0.01 mg/kg to 25 mg/kg body weight, preferably from about 0.01 mg/kg to about 15 mg/kg, more preferably from about 0.01 mg/kg to about 10 mg/kg, even more preferably from about 0.01 mg/kg to about 1 mg/kg, most preferably from about 0.05 mg/kg to about 1 mg/kg body weight. The amount of a compound according to the present invention, also referred to here as the active ingredient, which is required to achieve a therapeutically effect may vary on case-by-case basis, for example with the particular compound, the route of administration, the age and condition of the recipient, and the particular disorder or disease being treated. A method of treatment may also include administering the active ingredient on a regimen of between one and four intakes per day. In these methods of treatment the compounds according to the invention are preferably formulated prior to administration. As described herein below, suitable pharmaceutical formulations are prepared by known procedures using well known and readily available ingredients. 
     The present invention also provides compositions for preventing or treating the disorders referred to herein. Said compositions comprising a therapeutically effective amount of a compound of Formula (I), or a tautomer or a stereoisomeric form thereof, or a pharmaceutically acceptable salt, or a solvate thereof, and a pharmaceutically acceptable carrier or diluent. 
     While it is possible for the active ingredient to be administered alone, it is preferable to present it as a pharmaceutical composition. Accordingly, the present invention further provides a pharmaceutical composition comprising a compound according to the present invention, together with a pharmaceutically acceptable carrier or diluent. The carrier or diluent must be “acceptable” in the sense of being compatible with the other ingredients of the composition and not deleterious to the recipients thereof. 
     The pharmaceutical compositions of this invention may be prepared by any methods well known in the art of pharmacy, for example, using methods such as those described in Gennaro et al. Remington&#39;s Pharmaceutical Sciences (18 th  ed., Mack Publishing Company, 1990, see especially Part 8: Pharmaceutical preparations and their Manufacture). A therapeutically effective amount of the particular compound, in base form or addition salt form, as the active ingredient is combined in intimate admixture with a pharmaceutically acceptable carrier, which may take a wide variety of forms depending on the form of preparation desired for administration. These pharmaceutical compositions are desirably in unitary dosage form suitable, preferably, for systemic administration such as oral, percutaneous or parenteral administration; or topical administration such as via inhalation, a nose spray, eye drops or via a cream, gel, shampoo or the like. For example, in preparing the compositions in oral dosage form, any of the usual pharmaceutical media may be employed, such as, for example, water, glycols, oils, alcohols and the like in the case of oral liquid preparations such as suspensions, syrups, elixirs and solutions: or solid carriers such as starches, sugars, kaolin, lubricants, binders, disintegrating agents and the like in the case of powders, pills, capsules and tablets. Because of their ease in administration, tablets and capsules represent the most advantageous oral dosage unit form, in which case solid pharmaceutical carriers are obviously employed. For parenteral compositions, the carrier will usually comprise sterile water, at least in large part, though other ingredients, for example, to aid solubility, may be included. Injectable solutions, for example, may be prepared in which the carrier comprises saline solution, glucose solution or a mixture of saline and glucose solution. Injectable suspensions may also be prepared in which case appropriate liquid carriers, suspending agents and the like may be employed. In the compositions suitable for percutaneous administration, the carrier optionally comprises a penetration enhancing agent and/or a suitable wettable agent, optionally combined with suitable additives of any nature in minor proportions, which additives do not cause any significant deleterious effects on the skin. Said additives may facilitate the administration to the skin and/or may be helpful for preparing the desired compositions. These compositions may be administered in various ways, e.g., as a transdermal patch, as a spot-on or as an ointment. 
     It is especially advantageous to formulate the aforementioned pharmaceutical compositions in dosage unit form for ease of administration and uniformity of dosage. Dosage unit form as used in the specification and claims herein refers to physically discrete units suitable as unitary dosages, each unit containing a predetermined quantity of active ingredient calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier. Examples of such dosage unit forms are tablets (including scored or coated tablets), capsules, pills, powder packets, wafers, injectable solutions or suspensions, teaspoonfuls, tablespoonfuls and the like, and segregated multiples thereof. 
     The present compounds can be used for systemic administration such as oral, percutaneous or parenteral administration; or topical administration such as via inhalation, a nose spray, eye drops or via a cream, gel, shampoo or the like. The compounds are preferably orally administered. The exact dosage and frequency of administration depends on the particular compound of Formula (I) used, the particular condition being treated, the severity of the condition being treated, the age, weight, sex, extent of disorder and general physical condition of the particular patient as well as other medication the individual may be taking, as is well known to those skilled in the art. Furthermore, it is evident that said effective daily amount may be lowered or increased depending on the response of the treated subject and/or depending on the evaluation of the physician prescribing the compounds of the instant invention. 
     The compounds of the present invention may be administered alone or in combination with one or more additional therapeutic agents. Combination therapy includes administration of a single pharmaceutical dosage formulation which contains a compound according to the present invention and one or more additional therapeutic agents, as well as administration of the compound according to the present invention and each additional therapeutic agent in its own separate pharmaceutical dosage formulation. For example, a compound according to the present invention and a therapeutic agent may be administered to the patient together in a single oral dosage composition such as a tablet or capsule, or each agent may be administered in separate oral dosage formulations. 
     For the treatment of the above conditions, the compounds of the invention may be advantageously employed in combination with one or more other medicinal agents, more particularly, with other anti-cancer agents or adjuvants in cancer therapy. Examples of anti-cancer agents or adjuvants (supporting agents in the therapy) include but are not limited to:
         platinum coordination compounds for example cisplatin optionally combined with amifostine, carboplatin or oxaliplatin;   taxane compounds for example paclitaxel, paclitaxel protein bound particles (Abraxane™) or docetaxel;   topoisomerase I inhibitors such as camptothecin compounds for example irinotecan, SN-38, topotecan, topotecan hcl;   topoisomerase II inhibitors such as anti-tumour epipodophyllotoxins or podophyllotoxin derivatives for example etoposide, etoposide phosphate or teniposide;   anti-tumour vinca alkaloids for example vinblastine, vincristine or vinorelbine;   anti-tumour nucleoside derivatives for example 5-fluorouracil, leucovorin, gemcitabine, gemcitabine hcl, capecitabine, cladribine, fludarabine, nelarabine;   alkylating agents such as nitrogen mustard or nitrosourea for example cyclophosphamide, chlorambucil, carmustine, thiotepa, mephalan (melphalan), lomustine, altretamine, busulfan, dacarbazine, estramustine, ifosfamide optionally in combination with mesna, pipobroman, procarbazine, streptozocin, temozolomide, uracil;   anti-tumour anthracycline derivatives for example daunorubicin, doxorubicin optionally in combination with dexrazoxane, doxil, idarubicin, mitoxantrone, epirubicin, epirubicin hcl, valrubicin;   molecules that target the IGF-1 receptor for example picropodophilin;   tetracarcin derivatives for example tetrocarcin A;   glucocorticoden for example prednisone;   antibodies for example trastuzumab (HER2 antibody), rituximab (CD20 antibody), gemtuzumab, gemtuzumab ozogamicin, cetuximab, pertuzumab, bevacizumab, alemtuzumab, eculizumab, ibritumomab tiuxetan, nofetumomab, panitumumab, tositumomab, CNTO 328;   estrogen receptor antagonists or selective estrogen receptor modulators or inhibitors of estrogen synthesis for example tamoxifen, fulvestrant, toremifene, droloxifene, faslodex, raloxifene or letrozole;   aromatase inhibitors such as exemestane, anastrozole, letrazole, testolactone and vorozole;   differentiating agents such as retinoids, vitamin D or retinoic acid and retinoic acid metabolism blocking agents (RAMBA) for example accutane;   DNA methyl transferase inhibitors for example azacytidine or decitabine;   antifolates for example premetrexed disodium;   antibiotics for example antinomycin D, bleomycin, mitomycin C, dactinomycin, carminomycin, daunomycin, levamisole, plicamycin, mithramycin;   antimetabolites for example clofarabine, aminopterin, cytosine arabinoside or methotrexate, azacitidine, cytarabine, floxuridine, pentostatin, thioguanine;   apoptosis inducing agents and antiangiogenic agents such as Bcl-2 inhibitors for example YC 137, BH 312, ABT 737, gossypol, HA 14-1, TW 37 or decanoic acid;   tubuline-binding agents for example combrestatin, colchicines or nocodazole;   kinase inhibitors (e.g. EGFR (epithelial growth factor receptor) inhibitors, MTKI (multi target kinase inhibitors), mTOR inhibitors) for example flavoperidol, imatinib mesylate, erlotinib, gefitinib, dasatinib, lapatinib, lapatinib ditosylate, sorafenib, sunitinib, sunitinib maleate, temsirolimus;   famesyltransferase inhibitors for example tipifamib;   histone deacetylase (HDAC) inhibitors for example sodium butyrate, suberoylanilide hydroxamic acid (SAHA), depsipeptide (FR 901228), NVP-LAQ824, R306465, quisinostat, trichostatin A, vorinostat;   Inhibitors of the ubiquitin-proteasome pathway for example PS-341, MLN 0.41 or bortezomib;   Yondelis;   Telomerase inhibitors for example telomestatin;   Matrix metalloproteinase inhibitors for example batimastat, marimastat, prinostat or metastat;   Recombinant interleukins for example aldesleukin, denileukin diftitox, interferon alfa 2a, interferon alfa 2b, peginterferon alfa 2b;   MAPK inhibitors;   Retinoids for example alitretinoin, bexarotene, tretinoin;   Arsenic trioxide;   Asparaginase;   Steroids for example dromostanolone propionate, megestrol acetate, nandrolone (decanoate, phenpropionate), dexamethasone;   Gonadotropin releasing hormone agonists or antagonists for example abarelix, goserelin acetate, histrelin acetate, leuprolide acetate;   Thalidomide, lenalidomide;   Mercaptopurine, mitotane, pamidronate, pegademase, pegaspargase, rasburicase;   BH3 mimetics for example ABT-737;   MEK inhibitors for example PD98059, AZD6244, CI-1040;   colony-stimulating factor analogs for example filgrastim, pegfilgrastim, sargramostim; erythropoietin or analogues thereof (e.g. darbepoetin alfa); interleukin 11; oprelvekin; zoledronate, zoledronic acid; fentanyl; bisphosphonate; palifermin;   a steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase inhibitor (CYP17), e.g. abiraterone, abiraterone acetate.       

     Therefore, an embodiment of the present invention relates to a product containing as first active ingredient a compound according to the invention and as further active ingredient one or more anticancer agent, as a combined preparation for simultaneous, separate or sequential use in the treatment of patients suffering from cancer. 
     The one or more other medicinal agents and the compound according to the present invention may be administered simultaneously (e.g. in separate or unitary compositions) or sequentially in either order. In the latter case, the two or more compounds will be administered within a period and in an amount and manner that is sufficient to ensure that an advantageous or synergistic effect is achieved. It will be appreciated that the preferred method and order of administration and the respective dosage amounts and regimes for each component of the combination will depend on the particular other medicinal agent and compound of the present invention being administered, their route of administration, the particular tumour being treated and the particular host being treated. The optimum method and order of administration and the dosage amounts and regime can be readily determined by those skilled in the art using conventional methods and in view of the information set out herein. 
     The weight ratio of the compound according to the present invention and the one or more other anticancer agent(s) when given as a combination may be determined by the person skilled in the art. Said ratio and the exact dosage and frequency of administration depends on the particular compound according to the invention and the other anticancer agent(s) used, the particular condition being treated, the severity of the condition being treated, the age, weight, gender, diet, time of administration and general physical condition of the particular patient, the mode of administration as well as other medication the individual may be taking, as is well known to those skilled in the art. Furthermore, it is evident that the effective daily amount may be lowered or increased depending on the response of the treated subject and/or depending on the evaluation of the physician prescribing the compounds of the instant invention. A particular weight ratio for the present compound of Formula (I) and another anticancer agent may range from 1/10 to 10/1, more in particular from 1/5 to 5/1, even more in particular from 1/3 to 3/1. 
     The platinum coordination compound is advantageously administered in a dosage of 1 to 500 mg per square meter (mg/m2) of body surface area, for example 50 to 400 mg/m2, particularly for cisplatin in a dosage of about 75 mg/m2 and for carboplatin in about 300 mg/m2 per course of treatment. 
     The taxane compound is advantageously administered in a dosage of 50 to 400 mg per square meter (mg/m2) of body surface area, for example 75 to 250 mg/m2, particularly for paclitaxel in a dosage of about 175 to 250 mg/m2 and for docetaxel in about 75 to 150 mg/m2 per course of treatment. 
     The camptothecin compound is advantageously administered in a dosage of 0.1 to 400 mg per square meter (mg/m2) of body surface area, for example 1 to 300 mg/m2, particularly for irinotecan in a dosage of about 100 to 350 mg/m2 and for topotecan in about 1 to 2 mg/m2 per course of treatment. 
     The anti-tumour podophyllotoxin derivative is advantageously administered in a dosage of 30 to 300 mg per square meter (mg/m2) of body surface area, for example 50 to 250 mg/m2, particularly for etoposide in a dosage of about 35 to 100 mg/m2 and for teniposide in about 50 to 250 mg/m2 per course of treatment. 
     The anti-tumour  vinca  alkaloid is advantageously administered in a dosage of 2 to 30 mg per square meter (mg/m2) of body surface area, particularly for vinblastine in a dosage of about 3 to 12 mg/m2, for vincristine in a dosage of about 1 to 2 mg/m2, and for vinorelbine in dosage of about 10 to 30 mg/m2 per course of treatment. 
     The anti-tumour nucleoside derivative is advantageously administered in a dosage of 200 to 2500 mg per square meter (mg/m2) of body surface area, for example 700 to 1500 mg/m2, particularly for 5-FU in a dosage of 200 to 500 mg/m2, for gemcitabine in a dosage of about 800 to 1200 mg/m2 and for capecitabine in about 1000 to 2500 mg/m2 per course of treatment. 
     The alkylating agents such as nitrogen mustard or nitrosourea is advantageously administered in a dosage of 100 to 500 mg per square meter (mg/m2) of body surface area, for example 120 to 200 mg/m2, particularly for cyclophosphamide in a dosage of about 100 to 500 mg/m2, for chlorambucil in a dosage of about 0.1 to 0.2 mg/kg, for carmustine in a dosage of about 150 to 200 mg/m2, and for lomustine in a dosage of about 100 to 150 mg/m2 per course of treatment. 
     The anti-tumour anthracycline derivative is advantageously administered in a dosage of 10 to 75 mg per square meter (mg/m2) of body surface area, for example 15 to 60 mg/m2, particularly for doxorubicin in a dosage of about 40 to 75 mg/m2, for daunorubicin in a dosage of about 25 to 45 mg/m2, and for idarubicin in a dosage of about 10 to 15 mg/m2 per course of treatment. 
     The antiestrogen agent is advantageously administered in a dosage of about 1 to 100 mg daily depending on the particular agent and the condition being treated. Tamoxifen is advantageously administered orally in a dosage of 5 to 50 mg, preferably 10 to 20 mg twice a day, continuing the therapy for sufficient time to achieve and maintain a therapeutic effect. Toremifene is advantageously administered orally in a dosage of about 60 mg once a day, continuing the therapy for sufficient time to achieve and maintain a therapeutic effect. Anastrozole is advantageously administered orally in a dosage of about 1 mg once a day. Droloxifene is advantageously administered orally in a dosage of about 20-100 mg once a day. Raloxifene is advantageously administered orally in a dosage of about 60 mg once a day. Exemestane is advantageously administered orally in a dosage of about 25 mg once a day. 
     Antibodies are advantageously administered in a dosage of about 1 to 5 mg per square meter (mg/m2) of body surface area, or as known in the art, if different. Trastuzumab is advantageously administered in a dosage of 1 to 5 mg per square meter (mg/m2) of body surface area, particularly 2 to 4 mg/m2 per course of treatment. 
     These dosages may be administered for example once, twice or more per course of treatment, which may be repeated for example every 7, 14, 21 or 28 days. 
     The following examples further illustrate the present invention. 
     EXAMPLES 
     Several methods for preparing the compounds of this invention are illustrated in the following examples. Unless otherwise noted, all starting materials were obtained from commercial suppliers and used without further purification. 
     Herein, the term ‘DCE’ means 1,2-dichloroethane, ‘DCM’ means dichloromethane, ‘BEH’ means bridged ethylsiloxane/silica hybrid, ‘DIPEA’ means diisopropylethylamine, ‘DMAP’ means N,N-dimethylpyridin-4-amine, ‘DMF’ means N,N-dimethylformamide, ‘DMSO’ means dimethylsulfoxide, ‘Et 2 O’ means diethyl ether, ‘UPLC’ means ultra performance liquid chromatography, ‘LC’ means liquid chromatography, ‘EtOAc’ means ethyl acetate, ‘Celite®’ means diatomaceous earth, ‘HPLC’ means high performance liquid chromatography, ‘LCMS’ means liquid chromatography/mass spectrometry, ‘MeCN’ means acetonitrile, ‘MeOH’ means methanol, ‘NMP’ means N-methylpyrrolidinone, ‘R t ’ means retention time, ‘ISOLUTE® SCX-2 SPE’ means ISOLUTE® silica propylsulfonic acid strong cation exchange column, ‘TBAF’ means tetrabutylammonium fluoride, ‘SFC’ means supercritical fluid chromatography, ‘TFA’ means trifluoroacetic acid and ‘THF’ means tetrahydrofuran. 
     In the structures of the intermediates and the compounds of the present invention, deuterium ( 2 H) is represented by the chemical symbol D. 
     Preparation of Intermediates 
     Example A1 
     a) Preparation of Intermediate 1 
     
       
         
         
             
             
         
       
     
     A stirred solution of (methyldiphenylsilyl)acetylene (4.95 ml, 22.5 mmol) in anhydrous THF (80 ml) under an argon atmosphere at −78° C. was treated with a 1.6 M solution of n-butyllithium in hexanes (15.5 ml, 24.8 mmol) maintaining the temperature below −70° C. After 1 hour, the mixture was treated with acetone-d 6  (1.95 ml, 27.0 mmol) and the resulting mixture stirred at 0° C. for 1.5 hours. The mixture was quenched by the addition of water and partitioned between water and EtOAc. The organic phase was washed with brine, dried over Na 2 SO 4  and concentrated in vacuo. The residue was purified by column chromatography on silica gel, eluting with a mixture of EtOAc and cyclohexane (0:1 to 2:3 by volume), to afford the desired product as a colourless oil (6.31 g, 98%). 
     Example A2 
     a) Preparation of Intermediate 2 
     
       
         
         
             
             
         
       
     
     A stirred solution of (methyldiphenylsilyl)acetylene (80.0 g, 359.8 mmol) in anhydrous tetrahydrofuran (1200 ml) under an argon atmosphere at −78° C. was treated with n-butyllithium (23.5 g, 367 mmol) maintaining the temperature below −70° C. After stirring for 1 hour, the mixture was treated with 1-cyclopropyl-ethanone (36.3 g, 432 mmol) and the resulting mixture stirred at 0° C. for 1.5 hours. The mixture was quenched by the addition of water and partitioned between water and EtOAc. The organic phase was washed with brine, dried over Na 2 SO 4  and concentrated in vacuo. The residue was purified by chiral preparative SFC with the following conditions: column, ChiralPak IC, 300×50 mm, 10 μm; mobile phase, CO 2  (90%) and a mixture of heptane and isopropanol (1:1 by volume) (10%); flow rate 200 ml/min, back pressure 100 bar; detector, UV 220 nm; column temperature 38° C. The first eluting enantiomer was isolated as an off-white solid (20.2 g, 47.5%). The second eluting enantiomer (intermediate 2; R or S enantiomer) was isolated as an off-white solid (20.2 g, 47.5%). 
     Example A3 
     a) Preparation of Intermediate 3 
     
       
         
         
             
             
         
       
     
     A stirred solution of 6-bromo-1H-pyrrolo[3,2-c]pyridine-3-carboxaldehyde (15.0 g, 66.7 mmol) in DMF (150 ml) under a nitrogen atmosphere at 0° C. was treated with sodium hydride (60% in mineral oil, 3.20 g, 80.0 mmol). After stirring for 15 minutes, the mixture was treated with p-toluenesulfonyl chloride (14.0 g, 73.3 mmol) and warmed to ambient temperature over 1 hour. The reaction was diluted with water and the resulting precipitate was collected by filtration. The filter cake was washed sequentially with water and Et 20 , and dried in vacuo to afford the desired product as a beige solid (22.7 g, 90%). 
     LCMS (Method B): R t =3.48 min, m/z [M+H] + =379/381. 
     b) Preparation of Intermediate 4 
     
       
         
         
             
             
         
       
     
     A suspension of intermediate 3 (10.0 g, 26.4 mmol), methyl(triphenylphosphoranylidene)acetate (10.6 g, 30.4 mmol) and MeOH (500 ml) was stirred at ambient temperature for 1 hour. The mixture was concentrated in vacuo and the residue purified by column chromatography on silica gel, eluting with a mixture of EtOAc and cyclohexane (0:1 to 3:7 by volume), to afford the desired product as a white solid (7.5 g, 65%). 
     LCMS (Method B): R t =4.03 min, m/z [M+H] + =435/437. 
     c) Preparation of Intermediate 5 
     
       
         
         
             
             
         
       
     
     A mixture of intermediate 4 (7.5 g, 17.2 mmol), platinum (5% on charcoal, 2.0 g), DCM (200 ml) and MeOH (50 ml) under a hydrogen atmosphere was stirred at ambient temperature for 23 hours. A further aliquot of platinum (5% on charcoal, 2.0 g) was added and the resulting mixture stirred under a hydrogen atmosphere at ambient temperature for 18 hours. The mixture was filtered through Celite® and the filtrate concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with a mixture of EtOAc and cyclohexane (0:1 to 2:3 by volume). Further purification by column chromatography on silica gel, eluting with a mixture of EtOAc and cyclohexane (0:1 to 2:3 by volume), afforded the desired product as a white solid (3.57 g, 47%). 
     LCMS (Method B): R t =3.88 min, m/z [M+H] + =437/439. 
     d) Preparation of Intermediate 6 
     
       
         
         
             
             
         
       
     
     A stirred solution of intermediate 5 (1.0 g, 2.29 mmol) in THF (40 ml) under a nitrogen atmosphere at 0° C. was treated with 1.4 M solution of methylmagnesium bromide solution in a mixture of THF and toluene (1:3 by volume) (8.17 ml, 11.4 mmol) and the resulting mixture was stirred for 1 hour. The mixture was diluted with water, and partitioned between EtOAc and saturated aqueous sodium bicarbonate solution. The organic phase was washed with brine, dried over Na 2 SO 4  and concentrated in vacuo to afford the desired product as a white foam (0.99 g, 99%). 
     LCMS (Method B): R t =3.51 min, m/z [M+H] + =437/439. 
     e) Preparation of Intermediate 7 
     
       
         
         
             
             
         
       
     
     A stirred solution of intermediate 6 (0.99 g, 2.27 mmol) in MeOH (5.0 ml) and THF (15 ml) at ambient temperature was treated with sodium methoxide (25% wt. in MeOH, 5.2 ml, 22.6 mmol) and the resulting mixture was stirred for 30 minutes. The mixture was concentrated in vacuo and partitioned between EtOAc and saturated aqueous sodium bicarbonate solution. The organic phase was washed with brine, dried over Na 2 SO 4  and concentrated in vacuo to afford the desired product as a white solid (0.61 g, 95%). 
     LCMS (Method B): R t =1.95 min, m/z [M+H] + =283/285. 
     Example A4 
     a) Preparation of Intermediate 8 
     
       
         
         
             
             
         
       
     
     A stirred solution of 6-bromo-5-azaindole (3.00 g, 15.2 mmol) in DMF (30 ml) at ambient temperature was treated with powdered potassium hydroxide (3.42 g, 60.9 mmol). After stirring for 15 minutes, iodine (4.25 g, 16.74 mmol) was added and the resulting mixture was stirred for 18 hours. The mixture was concentrated in vacuo and the residue triturated with water to afford the desired product as a cream solid (5.06 g, 100%). 
     LCMS (Method C): R t =2.92 min, m/z [M+H] + =322/324. 
     b) Preparation of Intermediate 9 
     
       
         
         
             
             
         
       
     
     A stirred solution of intermediate 8 (4.92 g, 15.2 mmol), DMAP (0.037 g, 0.30 mmol) and DIPEA (5.82 ml, 33.4 mmol) in DCM (110 ml) under a nitrogen atmosphere at ambient temperature was treated with p-toluenesulfonyl chloride (3.47 g, 18.2 mmol), and the resulting mixture was stirred for 1 hour. The mixture was partitioned between water and DCM. The organic phase was washed with brine, dried over Na 2 SO 4  and concentrated in vacuo. The residue was purified by column chromatography on silica gel, eluting with DCM, to afford the desired product as a white solid (5.87 g, 81%). 
     LCMS (Method C): R t =4.37 min, m/z [M+H] + =477/479. 
     c) Preparation of Intermediate 10 
     
       
         
         
             
             
         
       
     
     A stirred suspension of intermediate 9 (3.67 g, 7.69 mmol), isopropenylboronic acid pinacol ester (1.61 ml, 8.14 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II)-dichloromethane complex (0.32 g, 0.39 mmol) and Cs 2 CO 3  (7.52 g, 23.1 mmol) in 1,4-dioxane (65 ml) and water (20 ml) was heated at 100° C. for 3 hours. The mixture was cooled to ambient temperature, and partitioned between EtOAc and saturated aqueous sodium bicarbonate. The organic phase was washed with brine, dried over Na 2 SO 4  and concentrated in vacuo. The residue was purified by column chromatography on silica gel, eluting with a mixture of EtOAc and pentane (0:1 to 1:9 by volume), to afford the desired product as a pale yellow solid (2.33 g, 78%). 
     LCMS (Method C): R t =4.41 min, m/z [M+H] + =391/393. 
     d) Preparation of Intermediate 11 
     
       
         
         
             
             
         
       
     
     A solution of intermediate 10 (2.33 g, 5.96 mmol) in ethanol (40 ml) and EtOAc (100 ml) under a hydrogen atmosphere at ambient temperature was treated with platinum (10% on charcoal, 0.60 g, 0.31 mmol), and the resulting mixture was stirred for 6 hours. The mixture was filtered through Celite® and the filtrate concentrated in vacuo to afford the desired product as a brown oil (2.08 g, 89%). 
     LCMS (Method C): R t =4.41 min, m/z [M+H] + =393/395. 
     e) Preparation of Intermediate 12 
     
       
         
         
             
             
         
       
     
     A solution of intermediate 11 (2.0 g, 5.08 mmol) in MeOH(80 ml) and THF (20 ml) at ambient temperature was treated with sodium methoxide (25% wt. in methanol, 2.75 g, 50.9 mmol), and the resulting mixture was stirred for 3 hours. The mixture was concentrated in vacuo and the residues partitioned between EtOAc and saturated aqueous sodium bicarbonate solution. The organic phase was washed with brine, dried over Na 2 SO 4  and concentrated in vacuo. The residue was purified by column chromatography on silica gel, eluting with a mixture of EtOAc and pentane (0:1 to 3:17 by volume), to afford the desired product as a white solid (0.98 g, 81%). 
     LCMS (Method C): R t =2.42 min, m/z [M+H] + =239/241. 
     Example A5 
     a) Preparation of Intermediate 13 
     
       
         
         
             
             
         
       
     
     A stirred solution of 5-bromo-1H-pyrrolo[2,3-c]pyridine (2.22 g, 11.3 mmol) in DMF (30 ml) at ambient temperature was treated with potassium hydroxide (2.53 g, 45.1 mmol). After 10 minutes, iodine (3.15 g, 12.4 mmol) was added and the resulting mixture was stirred for 2 hours. The mixture was diluted with water and extracted with EtOAc. The organic phase was washed with brine, dried over Na 2 SO 4  and concentrated in vacuo. The residue was triturated with water, filtered and dried in vacuo to afford the desired product as an orange solid (3.39 g, 93%). 
     LCMS (Method C): R t =3.14 min, m/z [M+H] + =323/325. 
     b) Preparation of Intermediate 14 
     
       
         
         
             
             
         
       
     
     A stirred suspension of intermediate 13 (3.39 g, 10.5 mmol) in DCM (60 ml) at 0° C. was treated sequentially with DMAP (0.128 g, 1.05 mmol), DIPEA (3.66 ml, 21.0 mmol) and di-tert-butyldicarbonate (3.44 g, 15.7 mmol). The resulting mixture was warmed to ambient temperature and stirred for 1 hour. The mixture was concentrated in vacuo and the residue triturated with water to afford the desired product as a pale yellow solid (4.24 g, 96%). 
     LCMS (Method C): R t =4.58 min, m/z [M+H] + =423/425. 
     c) Preparation of Intermediate 15 
     
       
         
         
             
             
         
       
     
     A degassed mixture of 2,4-dichloro-thieno[3,2-d]pyrimidine (0.39 g, 1.89 mmol), hexamethylditin (0.43 ml, 2.08 mmol), tetrakis(triphenylphosphine)palladium(0) (0.11 g, 0.095 mmol) and 1,4-dioxane (16 ml) under an argon atmosphere was heated at 80° C. for 1 hour. The mixture was cooled to ambient temperature, treated with a degassed solution of tetrakis(triphenylphosphine)palladium(0) (0.11 g, 0.095 mmol), intermediate 14 (0.80 g, 1.89 mmol) and copper thiophene carboxylate (0.04 g, 0.19 mmol) in 1,4-dioxane (4.0 ml), and the resulting mixture heated at 80° C. for 72 hours. The mixture was cooled to ambient temperature and concentrated in vacuo. The residue was diluted with DCM (10 ml) and treated with TFA (10 ml). The resulting mixture stirred at ambient temperature for 2 hours, then diluted with toluene and concentrated in vacuo. Trituration of the residue with EtOAc afforded the desired compound as a yellow solid (0.33 g, 48%). 
     LCMS (Method B): R t =3.41 min, m/z [M+H] + =365/367/369. 
     d) Preparation of Intermediate 16 
     
       
         
         
             
             
         
       
     
     A stirred mixture of intermediate 15 (0.33 g, 0.90 mmol), 1-bromo-3-methoxypropane (0.15 g, 0.99 mmol), Cs 2 CO 3  (0.59 g, 1.81 mmol) and DMF (3.0 ml) was heated by microwave irradiation at 110° C. for 1 hour. The mixture was cooled to ambient temperature and poured onto cold water. The resulting precipitate was collected by filtration, and washed sequentially with water and Et 2 O, to afford the desired product as a beige solid (0.32 g, 80%). 
     LCMS (Method B): R t =3.86 min, m/z [M+H] + =437/439/441. 
     Example A6 
     a) Preparation of Intermediate 17 
     
       
         
         
             
             
         
       
     
     A degassed mixture of intermediate 9 (1.23 g, 2.58 mmol), 3-methoxy-propyne (0.22 ml, 2.58 mmol), tetrakis(triphenylphosphine) palladium (0.15 g, 0.13 mmol), Et 3 N (1.80 ml, 12.9 mmol), copper(I) iodide (0.02 g, 0.13 mmol) and MeCN (8.0 ml) was heated at reflux for 4 hours. The mixture was cooled to ambient temperature and concentrated in vacuo. The residue was purified by column chromatography on silica gel, eluting with a mixture of EtOAc and cyclohexane (0:1 to 2:3 by volume), to afford the desired product as an off-white solid (0.99 g, 91%). 
     LCMS (Method C): R t =4.18 min, m/z [M+H] + =419/421. 
     b) Preparation of Intermediate 18 
     
       
         
         
             
             
         
       
     
     A suspension of intermediate 17 (0.99 g, 2.36 mmol) and Cs 2 CO 3  (2.31 g, 7.08 mmol) in MeOH (10 ml) and THF (20 ml) was stirred at ambient temperature for 2 hours. The mixture was concentrated in vacuo and the residue partitioned between EtOAc and saturated aqueous sodium bicarbonate solution. The organic phase was washed with brine, dried over Na 2 SO 4  and concentrated in vacuo. The residue was purified by column chromatography on silica gel, eluting with a mixture of EtOAc and cyclohexane (0:1 to 3:2 by volume), to afford the desired product as an off-white solid (0.39 g, 62%). 
     LCMS (Method C): R t =2.65 min, m/z [M+H] + =265/267. 
     c) Preparation of Intermediate 19 
     
       
         
         
             
             
         
       
     
     A mixture of intermediate 18 (0.39 g, 1.47 mmol), platinum (5% on charcoal, 0.10 g), DCM (30 ml) and MeOH (10 ml) under a hydrogen atmosphere was stirred at ambient temperature for 48 hours. The mixture was filtered through Celite® and the filtrate concentrated in vacuo. The residue was purified by column chromatography on silica gel, eluting with a mixture of EtOAc and cyclohexane (0:1 to 1:1 by volume), to afford the desired product as a white solid (0.19 g, 49%). 
     LCMS (Method C): R t =2.00 min, m/z [M+H] + =269/271. 
     Example A7 
     a) Preparation of Intermediate 20 
     
       
         
         
             
             
         
       
     
     A stirred solution of 6-bromo-1H-pyrrolo[3,2-c]pyridine (0.10 g, 0.51 mmol) in DMF (2.0 ml) under a nitrogen atmosphere at 0° C. was treated with sodium hydride (60% in mineral oil, 24.4 mg, 0.61 mmol). After stirring for 15 minutes, the mixture was treated with 2,4-dichloro-thieno[3,2-d]pyrimidine (0.10 g, 0.51 mmol) and warmed to ambient temperature. The reaction was diluted with water and the resulting precipitate collected by filtration. The filter cake was washed sequentially with water and Et 2 O, and dried in vacuo to afford the desired product as an off-white solid (0.16 g, 86%). 
     LCMS (Method B): R t =3.65 min, m/z [M+H]+=365/367/369. 
     b) Preparation of Intermediate 21 
     
       
         
         
             
             
         
       
     
     A stirred mixture of intermediate 20 (0.16 g, 0.44 mmol), 2-methyl-but-3-yn-2-ol (0.047 ml, 0.44 mmol), tetrakis(triphenylphosphine) palladium (0.10 g, 0.09 mmol), copper(I) iodide (0.0084 g, 0.04 mmol), Et 3 N (0.43 ml, 3.08 mmol) and MeCN (4.5 ml) was heated by microwave irradiation at 100° C. for 1 hour. The mixture was cooled to ambient temperature and concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with a mixture of MeOH and DCM (0:1 to 1:9 by volume). Further purification by column chromatography on silica gel, eluting with a mixture of MeOH and DCM (0:1 to 1:19 by volume), afforded the desired product as a pink solid (0.06 g, 37%). 
     LCMS (Method B): R t =2.54 min, m/z [M+H] + =369/371. 
     c) Preparation of Intermediate 22 
     
       
         
         
             
             
         
       
     
     A degassed suspension of intermediate 21 (0.06 g, 0.16 mmol), carbamic acid tert-butyl ester (0.06 g, 0.49 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.0075 g, 0.008 mmol), 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (0.0093 g, 0.016 mmol), Cs 2 CO 3  (0.13 g, 0.41 mmol) and 1,4-dioxane (3.0 ml) was heated at 100° C. for 1 hour. The mixture was cooled to ambient temperature and concentrated in vacuo. The residue was purified by column chromatography on silica gel, eluting with a mixture of MeOH and DCM (0:1 to 1:19 by volume), to afford the desired product as an off-white solid (0.04 g, 59%). 
     LCMS (Method B): R t =2.61 min, m/z [M+H] + =450. 
     Intermediates 23 to 25 were prepared by an analogous reaction protocol as intermediate 20 using the appropriate starting materials (Table 1). 
     
       
         
           
               
               
               
               
             
               
                 TABLE 1 
               
               
                   
               
               
                 Intermediate 
                 Structure 
                 Starting Material 
                 LCMS Data 
               
               
                   
               
             
            
               
                 23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) 2,4-Dichloro- thieno[3,2- d]pyrimidine b) Intermediate 7  
                 R t  = 3.68 min, m/z [M + H] +  = 451/453/455 (Method B)  
               
               
                   
               
               
                 24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) 2,4-Dichloro- thieno[3,2- d]pyrimidine b) Intermediate 12 
                 R t  = 4.47 min, m/z [M + H] +  = 407/409/411 (Method C) 
               
               
                   
               
               
                 25 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) 2,4-Dichloro- thieno[3,2- d]pyrimidine b) Intermediate 19 
                 R t  = 3.99 min, m/z [M + H] +  = 437/439/441 (Method A) 
               
               
                   
               
            
           
         
       
     
     Intermediate 26 was prepared by an analogous reaction protocol as intermediate 21 using the appropriate starting materials (Table 2). 
     
       
         
           
               
               
               
               
             
               
                 TABLE 2 
               
               
                   
               
               
                 Intermediate 
                 Structure 
                 Starting Material 
                 LCMS Data 
               
               
                   
               
             
            
               
                 26 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) 2-Methyl-but-3- yn-2-ol b) Intermediate 23 
                 R t  = 2.72 min, m/z [M + H] +  = 455/457 (Method B) 
               
               
                   
               
            
           
         
       
     
     Intermediate 27 was prepared by an analogous reaction protocol as intermediate 22 using the appropriate starting materials (Table 3). 
     
       
         
           
               
               
               
               
             
               
                 TABLE 3 
               
               
                   
               
               
                 Intermediate 
                 Structure 
                 Starting Material 
                 LCMS Data 
               
               
                   
               
             
            
               
                 27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) Carbamic acid tert-butyl ester b) Intermediate 26 
                 R t  = 2.80 min, m/z [M + H] +  = 536 (Method B) 
               
               
                   
               
            
           
         
       
     
     Example A8 
     a) Preparation of Intermediate 28 
     
       
         
         
             
             
         
       
     
     A stirred solution of 6-bromo-5-azaindole (4.00 g, 20.3 mmol) in MeOH (100 ml) at ambient temperature was treated with powdered potassium hydroxide (4.55 g, 81.1 mmol). After stirring for 10 minutes, the mixture was treated with N-methyl-piperidinone (4.99 g, 40.6 mmol) and heated at reflux for 72 hours. The mixture was cooled to ambient temperature and concentrated in vacuo. The residue was partitioned between water and EtOAc, and the organic phase was washed with brine, dried over Na 2 SO 4  and concentrated in vacuo. Trituration of the residue with Et 2 O afforded the desired product as a white solid (5.21 g, 88%). 
     LCMS (Method C): R t =0.30/079 min, m/z [M+H] + =292/294. 
     b) Preparation of Intermediate 29 
     
       
         
         
             
             
         
       
     
     A stirred solution of intermediate 28 (4.84 g, 16.6 mmol) in EtOAc (150 ml) under a hydrogen atmosphere (3.0 bar) at 25° C. was treated with platinum (5% on charcoal, 0.25 g), and the resulting mixture was stirred for 36 hours. The mixture was filtered through Celite® and the filtrate concentrated in vacuo. The residue was purified by column chromatography on silica gel, eluting with a mixture of MeOH and DCM (0:1 to 1:9 by volume), to afford the desired product as a white solid (1.37 g, 28%). 
     LCMS (Method C): R t =0.29/0.53 min, m/z [M+H] + =294/296. 
     c) Preparation of Intermediate 30 
     
       
         
         
             
             
         
       
     
     A stirred solution of intermediate 29 (0.40 g, 1.36 mmol) in DMF (5.0 ml) under a nitrogen atmosphere at 0° C. was treated with sodium hydride (60% in mineral oil, 0.08 g, 2.0 mmol). After stirring for 15 minutes, the mixture was treated with 2,4-dichloro-thieno[3,2-d]pyrimidine (0.31 g, 1.50 mmol) and the resulting mixture was stirred at ambient temperature for 2 hours. The mixture was diluted with water and the resulting precipitate collected by filtration. The filter cake was washed sequentially with water and acetone, and dried in vacuo to afford the desired product as an off-white solid (0.56 g, 89%). 
     LCMS (Method B): R t =2.47 min, m/z [M+H] + =462/464/466. 
     d) Preparation of Intermediate 31 
     
       
         
         
             
             
         
       
     
     A stirred mixture of intermediate 30 (0.10 g, 0.22 mmol), 3,4,5-trimethoxybenzylamine (0.21 g, 1.08 mmol), pyridine (0.17 g, 2.16 mmol) and NMP (1.5 ml) was heated by microwave irradiation at 180° C. for 1 hour. The mixture was cooled to ambient temperature and purified by ISOLUTE® SCX-2 SPE column eluting with a mixture of MeOH and 2.0 M ammonia solution in MeOH (1:0 to 0:1 by volume). Further purification by column chromatography on silica gel, eluting with a mixture of MeOH and DCM (0:1 to 1:9 by volume), afforded the desired product as a pale yellow solid (0.16 g, 99%). 
     LCMS (Method B): R t =2.41 min, m/z [M+H] + =623/625. 
     e) Preparation of Intermediate 32 
     
       
         
         
             
             
         
       
     
     A stirred mixture of intermediate 31 (0.16 g, 0.10 mmol) and TFA (1.0 ml, 13.1 mmol) was heated at reflux for 48 hours. The mixture was cooled to ambient temperature and concentrated in vacuo. The residue was purified by ISOLUTE® SCX-2 SPE column eluting with a mixture of MeOH and 2.0 M ammonia solution in MeOH (1:0 to 0:1 by volume). Further purification by column chromatography on silica gel, eluting with a mixture of 2.0 M ammonia solution in MeOH and DCM (0:1 to 1:9 by volume), afforded the desired product as a pale yellow solid (0.05 g, 40%). 
     LCMS (Method B): R t =1.86 min, m/z [M+H] + =443/445 
     Intermediates 33 to 36 were prepared by an analogous reaction protocol as intermediate 31 using the appropriate starting materials (Table 4). 
     
       
         
           
               
               
               
               
             
               
                 TABLE 4 
               
               
                   
               
               
                 Intermediate 
                 Structure 
                 Starting Material 
                 LCMS Data 
               
               
                   
               
             
            
               
                 33 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) 3,4,5- Trimethoxybenzylamine b) Intermediate 24  
                 R t  = 4.27 min, m/z [M + H] +  = 568/570 (Method B) 
               
               
                   
               
               
                 34 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) 3,4,5- Trimethoxybenzylamine b) Intermediate 16  
                 R t  = 3.11 min, m/z [M + H] +  = 598/600 (Method B) 
               
               
                   
               
               
                 35 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) 3,4,5- Trimethoxybenzylamine b) Intermediate 25  
                 R t  = 3.83 min, m/z [M + H] +  = 598/600 (Method B) 
               
               
                   
               
               
                 36 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) 3,4,5- Trimethoxybenzylamine b) Intermediate 15 
                 R t  = 2.71 min, m/z [M + H] +  = 526/528 (Method C) 
               
               
                   
               
            
           
         
       
     
     Intermediates 37 to 42 were prepared by an analogous reaction protocol as intermediate 32 using the appropriate starting material (Table 5). 
     
       
         
           
               
               
               
               
             
               
                 TABLE 5 
               
               
                   
               
               
                 Intermediate 
                 Structure 
                 Starting Material 
                 LCMS Data 
               
               
                   
               
             
            
               
                 37 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Intermediate 33 
                 R t  = 3.40 min, m/z [M + H] +  = 388/390 (Method B) 
               
               
                   
               
               
                 38 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Intermediate 34 
                 R t  = 2.28 min, m/z [M + H] +  = 418/420 (Method B) 
               
               
                   
               
               
                 39 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Intermediate 35 
                 R t  = 2.98 min, m/z [M + H] +  = 418/420 (Method B) 
               
               
                   
               
               
                 40 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Intermediate 36 
                 R t  = 2.00 min, m/z [M + H] +  = 346/348 (Method B) 
               
               
                   
               
               
                 41a and 41b 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Intermediate 54 
                 R t  = 1.79/1.82 min, m/z [M + H] +  = 457/459 (Method B) 
               
               
                   
               
               
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
                   
               
               
                   
               
               
                 42 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Intermediate 55 
                 R t  = 1.75 min, m/z [M + H] +  = 443/445 (Method C) 
               
               
                   
               
            
           
         
       
     
     Example A9 
     a) Preparation of Intermediate 43 
     
       
         
         
             
             
         
       
     
     A stirred mixture of intermediate 40 (0.13 g, 0.37 mmol), 3-iodooxetane (0.04 ml, 0.52 mmol), Cs 2 CO 3  (0.24 g, 0.75 mmol) and DMF (3.0 ml) was heated at 110° C. for 6 hours. A second aliquot of 3-iodooxetane (0.04 ml, 0.52 mmol) was added and the resulting mixture was heated at 110° C. for 5 hours. The mixture was cooled to ambient temperature and poured onto cold water. The resulting precipitate was collected by filtration, and washed sequentially with water and Et 2 O, to afford the desired product as a beige solid (0.10 g, 67%). 
     LCMS (Method B): R t =2.13 min, m/z [M+H]+=402/404. 
     Intermediates 44 to 47 were prepared by an analogous reaction protocol as Example A9 using the appropriate starting materials (Table 6). 
     
       
         
           
               
               
               
               
             
               
                 TABLE 6 
               
               
                   
               
               
                 Intermediate 
                 Structure 
                 Starting Materials 
                 LCMS Data 
               
               
                   
               
             
            
               
                 44 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) Intermediate 40 b) 4-Methane- sulfonyloxy-piperidine- 1-carboxylic acid tert- butyl ester 
                 R t  = 3.01 min, m/z [M + H] +  = 529/531 (Method B) 
               
               
                   
               
               
                 45 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) Intermediate 40 b) 3-Iodo-azetidine- 1-carboxylic acid tert-butyl ester  
                 R t  = 2.86 min, m/z [M + H] +  = 501/503 (Method B)  
               
               
                   
               
               
                 46 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) Intermediate 36 b) 3-Methane- sulfonyloxy-piperidine- 1-carboxylic acid tert- butyl ester  
                 R t  = 3.86 min, m/z [M + H] +  = 709/711 (Method B)  
               
               
                   
               
               
                 47 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) Intermediate 36 b) 3-Methane- sulfonyloxy-pyrrolidine- 1-carboxylic acid tert- butyl ester 
                 R t  = 3.70 min, m/z [M + H] +  = 695/697 (Method C) 
               
               
                   
               
            
           
         
       
     
     Example A10 
     a) Preparation of Intermediate 48 
     
       
         
         
             
             
         
       
     
     A stirred solution of intermediate 44 (0.46 g, 0.433 mmol) in DCM (3.0 ml) under a nitrogen atmosphere at ambient temperature was treated with TFA (3.0 ml, 39.0 mmol), and the resulting mixture was stirred for 1 hour. The mixture was concentrated in vacuo and the residue purified by ISOLUTE® SCX-2 SPE column, eluting with a mixture of MeOH and 2.0 M ammonia solution in MeOH (1:0 to 0:1 by volume), to afford the desired product as a yellow solid (0.17 g, 91.4%). 
     LCMS (Method B): R t =0.29 and 1.72 min, m/z [M+H] + =429/431. 
     b) Preparation of Intermediate 49 
     
       
         
         
             
             
         
       
     
     A stirred solution of intermediate 48 (0.17 g, 0.39 mmol) in a mixture of MeOH (4.0 ml) and acetic acid (2.0 ml) under a nitrogen atmosphere at ambient temperature was treated with (1-ethoxycyclopropoxy)trimethylsilane (0.40 ml, 1.98 mmol). After stirring for 10 minutes, the mixture was treated with sodium cyanoborohydride (0.15 g, 2.38 mmol) and the resulting mixture was stirred at 50° C. for 7.0 hours. The mixture was cooled to ambient temperature, concentrated in vacuo and partitioned between 2.0 M aqueous sodium carbonate solution and EtOAc. The organic phase was dried over Na 2 SO 4  and concentrated in vacuo. The residue was purified by ISOLUTE® SCX-2 SPE column, eluting with a mixture of MeOH and 2.0 M ammonia solution in MeOH (1:0 to 0:1 by volume), to afford the desired product as a yellow solid (0.06 g, 32%). 
     LCMS (Method B): R t =0.31 and 1.75 min, m/z [M+H] + =469/471. 
     Intermediates 50 to 52 were prepared by an analogous reaction protocol as intermediate 48 using the appropriate starting material (Table 7). 
     
       
         
           
               
               
               
               
             
               
                 TABLE 7 
               
               
                   
               
               
                 Intermediate 
                 Structure 
                 Starting Material 
                 LCMS Data 
               
               
                   
               
             
            
               
                 50 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Intermediate 45 
                 R t  = 1.48 min, m/z [M + H] +  = 401/403 (Method C) 
               
               
                   
               
               
                 51 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Intermediate 46 
                 R t  = 2.28 min, m/z [M + H] +  = 609/611 (Method C) 
               
               
                   
               
               
                 52 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Intermediate 47 
                 R t  = 2.18 min, m/z [M + H] +  = 595/597 (Method B) 
               
               
                   
               
            
           
         
       
     
     Intermediate 53 was prepared by an analogous reaction protocol as intermediate 49 using the appropriate starting materials (Table 8). 
     
       
         
           
               
               
               
               
             
               
                 TABLE 8 
               
               
                   
               
               
                 Intermediate 
                 Structure 
                 Starting Materials 
                 LCMS Data 
               
               
                   
               
             
            
               
                 53 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) Intermediate 50 b) (1-Ethoxy- cyclopropoxy) trimethylsilane 
                 R t  = 0.31 min, m/z [M + H] +  = 441/443 (Method C) 
               
               
                   
               
            
           
         
       
     
     Example A11 
     a) Preparation of Intermediate 54 
     
       
         
         
             
             
         
       
     
     A stirred mixture of intermediate 51 (0.11 g, 0.18 mmol), acetaldehyde (0.01 mg, 0.23 mmol), sodium acetate (0.02 g, 0.22 mmol), MeOH (3.0 ml) and DCE (3.0 ml) at 0° C. was treated with sodium triacetoxyborohydride (0.06 g, 0.27 mmol). The resulting mixture was warmed to ambient temperature and stirred for 1 hour. The mixture was concentrated in vacuo and the residue purified by ISOLUTE® SCX-2 SPE column, eluting with a mixture of MeOH and 2.0 M ammonia solution in MeOH (1:0 to 0:1 by volume), to afford the desired product as a light brown oil (0.11 g, 97%). 
     LCMS (Method B): R t =2.29 min, m/z [M+H]+=637/639. 
     Intermediate 55 was prepared by an analogous reaction protocol as intermediate 54 using the appropriate starting materials (Table 9). 
     
       
         
           
               
               
               
               
             
               
                 TABLE 9 
               
               
                   
               
               
                 Intermediate 
                 Structure 
                 Starting Materials 
                 LCMS Data 
               
               
                   
               
             
            
               
                 55 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) Intermediate 52 b) Acetaldehyde 
                 R t  = 2.22 min, m/z [M + H] +  = 623/625 (Method B) 
               
               
                   
               
            
           
         
       
     
     Preparation of Compounds 
     The values of acid content (e.g. formic acid or acetic acid) in the compounds as provided herein, are those obtained experimentally and may vary when using different analytical methods. The content of formic acid or acetic acid reported herein was determined by  1 H NMR integration and is reported together with the  1 H NMR results. Compounds with an acid content of below 0.5 equivalents may be considered as free bases. 
     Example B1 
     a) Preparation of Compound 1 
     
       
         
         
             
             
         
       
     
     A stirred solution of intermediate 22 (0.04 g, 0.096 mmol) in DCM (4.0 ml) under a nitrogen atmosphere at ambient temperature was treated with TFA (1.0 ml, 13.0 mmol), and the resulting mixture was stirred for 1 hour. The mixture was concentrated in vacuo and the residue purified by ISOLUTE® SCX-2 SPE column eluting with a mixture of MeOH and 2.0 M ammonia solution in MeOH (1:0 to 0:1 by volume). Further purification by reverse phase preparative HPLC, eluting with a mixture of MeCN and water containing 0.1% formic acid (1:19 to 49:1 by volume), afforded the desired product as a white solid (19 mg, 55%). 
       1 H NMR (400 MHz, DMSO-d 6 ) δ ppm: 8.93 (d, J=1.0 Hz, 1H), 8.35-8.33 (m, 2H), 8.18 (d, J=3.5 Hz, 1H), 7.29 (d, J=5.4 Hz, 1H), 7.07 (dd, J=0.7, 3.5 Hz, 1H), 7.01 (s, 2H), 5.56-5.49 (br .s., 1H), 1.51 (s, 6H). 
     LCMS (Method E): R t =2.44 min, m/z [M+H] + =350. 
     Compound 2 was prepared by an analogous reaction protocol as Example B1 using the appropriate starting material (Table 10). 
     
       
         
           
               
               
               
             
               
                 TABLE 10 
               
               
                   
               
               
                 Com- 
                   
                   
               
               
                 pound 
                 Structure 
                 Starting Material 
               
               
                   
               
             
            
               
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Intermediate 27 
               
               
                   
               
            
           
         
       
     
     Example B2 
     a) Preparation of Compound 3 
     
       
         
         
             
             
         
       
     
     A stirred mixture of intermediate 32 (0.04 g, 0.09 mmol), 2-methyl-but-3-yn-2-ol (0.093 g, 0.11 mmol), tetrakis(triphenylphosphine) palladium (0.02 g, 0.02 mmol), copper(I) iodide (0.0020 mg, 0.011 mmol), Et 3 N (0.09 ml, 0.646 mmol) and EtOAc (1.5 ml) was heated by microwave irradiation at 100° C. for 1 hour. The mixture was cooled to ambient temperature and concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with a mixture of 2.0 M ammonia solution in MeOH and DCM (0:1 to 1:9 by volume). Further purification by reverse phase preparative HPLC, eluting with a mixture of MeCN and water containing 0.1% formic acid (1:19 to 3:7 by volume over 20 min), afforded the desired product as a brown solid (0.016 g, 35%, contains formic acid 1.0 equivalents). 
       1 H NMR (400 MHz, DMSO-d 6 ) δ ppm: 9.00 (d, J=1.0 Hz, 1H), 8.33 (d, J=0.9 Hz, 1H), 8.31 (d, J=5.5 Hz, 1H), 8.22 (s, 1H), 7.90 (d, J=0.8 Hz, 1H), 7.28 (d, J=5.5 Hz, 1H), 6.97 (s, 2H), 5.51 (s, 1H), 2.98-2.90 (m, 3H), 2.27 (s, 3H), 2.20-2.11 (m, 2H), 2.05 (d, J=12.6 Hz, 2H), 1.84-1.71 (m, 2H), 1.50 (s, 6H). 
     LCMS (Method E): R t =2.03 min, m/z [M+H] + =447. 
     Compounds 4 to 8 were prepared by an analogous reaction protocol as Example B2 using the appropriate starting materials (Table 11). 
     
       
         
           
               
               
               
             
               
                 TABLE 11 
               
               
                   
               
               
                 Com- 
                   
                   
               
               
                 pound 
                 Structure 
                 Starting Materials 
               
               
                   
               
             
            
               
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) Intermediate 37 b) 2-Methyl-but-3- yn-2-ol  
               
               
                   
               
               
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) Intermediate 38 b) 2-Methyl-but-3- yn-2-ol  
               
               
                   
               
               
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) Intermediate 39 b) 2-Methyl-but-3- yn-2-ol  
               
               
                   
               
               
                 7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) Intermediate 43 b) 2-Methyl-but-3- yn-2-ol  
               
               
                   
               
               
                 8 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 a) Intermediate 49 b) 2-Cyclopropyl- but-3-yn-2-ol 
               
               
                   
               
            
           
         
       
     
     Example B3 
     a) Preparation of Compound 9 
     
       
         
         
             
             
         
       
     
     A degassed mixture of intermediate 49 (0.05 g, 0.102 mmol), intermediate 1 (0.04 g, 0.15 mmol), tetrakis(triphenylphosphine) palladium (0.02 g, 0.02 mmol), copper(I) iodide (0.002 g, 0.01 mmol), Et 3 N (0.10 ml, 0.714 mmol) and MeCN (3.0 ml) was treated with 1.0 M solution of TBAF in THF (0.05 ml, 0.05 mmol). The resulting mixture was heated by microwave irradiation at 100° C. for 1 hour. The mixture cooled to ambient temperature and concentrated in vacuo. The residue was partitioned between EtOAc and water and the organic phase was washed with brine, dried over Na 2 SO 4  and concentrated in vacuo. The residue was purified by ISOLUTE® SCX-2 SPE column washing with MeOH, followed by elution with 2.0 M ammonia in MeOH. Further purification by reverse phase preparative HPLC, eluting with a mixture of MeCN and water containing 0.1% formic acid (1:9 to 3:2 by volume over 20 min), afforded the desired product as a pale yellow solid (0.01 g, 20%, contains formic acid 0.8 equivalents). 
       1 H NMR (400 MHz, DMSO-d 6 ) δ ppm: 9.07 (d, J=1.0 Hz, 1H), 8.61 (d, J=1.1 Hz, 1H), 8.38 (s, 1H), 8.20 (d, J=5.5 Hz, 1H), 8.14 (s, 0.8H), 7.22 (d, J=5.5 Hz, 1H), 6.62 (s, 2H), 5.47 (s, 1H), 4.80-4.70 (m, 1H), 3.15-3.08 (m, 2H), 2.55-2.52 (m, 2H), 2.14-2.01 (m, 4H), 1.77-1.70 (m, 1H), 0.51-0.45 (m, 2H), 0.39-0.33 (m, 2H). 
     LCMS (Method E): R t =2.05 min, m/z [M+H] + =479. 
     Compounds 10 to 14 were prepared by an analogous reaction protocol as Example B3 using the appropriate starting materials (Table 12). 
                             TABLE 12               Com-               pound   Structure   Starting Materials                  10                         a) Intermediate 53 b) Intermediate 1                11                         a) Intermediate 53 b) Intermediate 2               12                         a) Intermediate 41a b) Intermediate 1                13                         a) Intermediate 41b b) Intermediate 1                14                         a) Intermediate 42 b) Intermediate 1                    
Analytical Part
 
LCMS
 
     Mass Spectrometry (LCMS) experiments to determine retention times and associated mass ions were performed using the following methods: 
     Method A: Experiments were performed on a Waters ZMD quadrupole mass spectrometer linked to a Waters 1525 LC system with a diode array detector. The spectrometer had an electrospray source operating in positive and negative ion mode. 
     Additional detection was achieved using a Sedex 85 evaporative light scattering detector. LC was carried out using a Luna 3 micron 30×4.6 mm C18 column and a 2 mL/minute flow rate. The initial solvent system was 95% water containing 0.1% formic acid (solvent A) and 5% MeCN containing 0.1% formic acid (solvent B) for the first 0.5 minute followed by a gradient up to 5% solvent A and 95% solvent B over the next 4 min. The final solvent system was held constant for a further 1 minute. 
     Method B: Experiments were performed on a Waters VG Platform II quadrupole spectrometer linked to a Hewlett Packard 1050 LC system with a diode array detector. The spectrometer had an electrospray source operating in positive and negative ion mode. Additional detection was achieved using a Sedex 85 evaporative light scattering detector. LC was carried out using a Luna 3 micron 30×4.6 mm C18 column and a 2 mL/minute flow rate. The initial solvent system was 95% water containing 0.1% formic acid (solvent A) and 5% MeCN containing 0.1% formic acid (solvent B) for the first 0.3 minute followed by a gradient up to 5% solvent A and 95% solvent B over the next 4 min. The final solvent system was held constant for a further 1 minute. 
     Method C: Experiments were performed on a Waters Platform LC quadrupole mass spectrometer linked to a Hewlett Packard HP 1100 LC system with diode array detector. 
     The spectrometer had an electrospray source operating in positive and negative ion mode. Additional detection was achieved using a Sedex 85 evaporative light scattering detector. LC was carried out using a Phenomenex Luna 3 micron 30×4.6 mm C18 column and a 2 mL/minute flow rate. The initial solvent system was 95% water containing 0.1% formic acid (solvent A) and 5% MeCN containing 0.1% formic acid (solvent B) for the first 0.5 minute followed by a gradient up to 5% solvent A and 95% solvent B over the next 4 min. The final solvent system was held constant for a further 1 minute. 
     Method D: Experiments were performed on a Waters ZQ quadrupole mass spectrometer linked to a Hewlett Packard HP 1100 LC system with quaternary pump and PDA detector. The spectrometer had an electrospray source operating in positive and negative ion mode. Additional detection was achieved using a Sedex 65 evaporative light scattering detector. LC was carried out using a Phenomenex Luna 3 micron 30×4.6 mm C18 column and a 2 mL/minute flow rate. The initial solvent system was 95% water containing 0.1% formic acid (solvent A) and 5% MeCN containing 0.1% formic acid (solvent B) for the first 0.3 minute followed by a gradient up to 5% solvent A and 95% solvent B over the next 4 min. The final solvent system was held constant for a further 1 minute. 
     Method E: Experiments were performed on a Waters Micromass ZQ2000 quadrupole mass spectrometer linked to a Waters Acquity UPLC system with a PDA UV detector. 
     The spectrometer had an electrospray source operating in positive and negative ion mode. LC was carried out using an Acquity BEH 1.7 micron C18 column, an Acquity BEH Shield 1.7 micron RP18 column or an Acquity HST 1.8 micron column. Each column has dimensions of 100×2.1 mm and was maintained at 40° C. with a flow rate of 0.4 mL/minute. The initial solvent system was 95% water containing 0.1% formic acid (solvent A) and 5% MeCN containing 0.1% formic acid (solvent B) for the first 0.4 minute followed by a gradient up to 5% solvent A and 95% solvent B over the next 5.2 min. The final solvent system was held constant for a further 0.8 min. 
     NMR Data 
     The NMR experiments herein were carried out using a Varian Unity Inova spectrometer with standard pulse sequences, operating at 400 MHz at ambient temperature. Chemical shifts (δ) are reported in parts per million (ppm) downfield from tetramethylsilane (TMS), which was used as internal standard. DMSO-d 6  (deuterated DMSO, dimethyl-d6 sulfoxide) was used as solvent. 
     The values of acid content (e.g. formic acid or acetic acid) in the compounds as provided herein, are those obtained experimentally and may vary when using different analytical methods. The content of formic acid or acetic acid reported herein was determined by  1 H NMR integration. Compounds with an acid content of below 0.5 equivalents may be considered as free bases. 
     Compound 2 
       1 H NMR (400 MHz, DMSO-d 6 ) δ ppm: 8.92 (d, J=1.0 Hz, 1H), 8.34 (d, J=0.9 Hz, 1H), 8.30 (d, J=5.5 Hz, 1H), 7.92 (s, 1H), 7.26 (d, J=5.4 Hz, 1H), 6.95 (s, 2H), 5.52 (s, 1H), 4.35 (s, 1H), 2.92-2.85 (m, 2H), 1.86-1.80 (m, 2H), 1.50 (s, 6H), 1.21 (s, 6H). 
     LCMS (Method E): R t =2.72 min, m/z [M+H] + =436. 
     Compound 4 
       1 H NMR (400 MHz, DMSO-d 6 ) δ ppm: 9.01 (s, 1H), 8.34 (s, 1H), 8.31 (d, J=5.4 Hz, 1H), 7.90 (d, J=0.8 Hz, 1H), 7.28 (d, J=5.4 Hz, 1H), 6.97 (s, 2H), 5.53 (s, 1H), 3.34 (s, 1H), 1.51 (s, 6H), 1.40 (d, J=6.8 Hz, 6H). 
     LCMS (Method E): R t =3.20 min, m/z [M+H] + =392. 
     Compound 5 
       1 H NMR (400 MHz, DMSO-d 6 ) δ ppm: 8.95 (d, J=1.0 Hz, 1H), 8.66 (d, J=1.0 Hz, 1H), 8.42 (s, 1H), 8.22 (d, J=5.5 Hz, 1H), 7.22 (d, J=5.5 Hz, 1H), 6.62 (s, 2H), 5.49 (s, 1H), 4.53 (t, J=6.7 Hz, 2H), 3.30-3.26 (m, 2H), 3.24 (s, 3H), 2.14-2.05 (m, 2H), 1.53 (s, 6H). 
     LCMS (Method E): R t =2.52 min, m/z [M+H] + =422. 
     Compound 6 
       1 H NMR (400 MHz, DMSO-d 6 ) δ ppm: 8.91 (d, J=0.9 Hz, 1H), 8.34 (d, J=1.1 Hz, 1H), 8.31 (d, J=5.5 Hz, 1H), 7.95 (s, 1H), 7.27 (d, J=5.5 Hz, 1H), 6.96 (s, 2H), 5.50 (s, 1H), 3.43 (t, J=6.3 Hz, 2H), 3.27 (s, 3H), 2.88 (t, J=7.5 Hz, 2H), 2.00-1.91 (m, 2H), 1.50 (s, 6H). 
     LCMS (Method E): R t =2.85 min, m/z [M+H] + =422. 
     Compound 7 
       1 H NMR (400 MHz, DMSO-d 6 ) δ ppm: 9.06 (s, 1H), 8.65 (d, J=0.9 Hz, 1H), 8.63 (s, 1H), 8.22 (d, J=5.1 Hz, 1H), 7.22 (d, J=5.5 Hz, 1H), 6.65 (s, 2H), 6.07-5.98 (m, 1H), 5.49 (s, 1H), 5.15 (t, J=7.4 Hz, 2H), 5.05-5.00 (m, 2H), 1.51 (s, 6H). 
     LCMS (Method E): R t =2.31 min, m/z [M+H] + =406. 
     Compound 8 
       1 H NMR (400 MHz, DMSO-d 6 ) δ ppm: 9.06 (s, 1H), 8.58 (d, J=1.0 Hz, 1H), 8.37 (s, 1H), 8.19 (d, J=5.5 Hz, 1H), 7.21 (d, J=5.5 Hz, 1H), 6.59 (s, 2H), 5.34 (s, 1H), 4.78-4.70 (m, 1H), 3.11 (d, J=11.2 Hz, 2H), 2.54-2.51 (m, 2H), 2.12-2.00 (m, 4H), 1.76-1.70 (m, 1H), 1.54 (s, 3H), 1.21-1.13 (m, 1H), 0.60-0.34 (m, 8H). 
     LCMS (Method E): R t =2.23 min, m/z [M+H] + =499. 
     A second batch was isolated with 0.5 equivalents of formic acid present. 
     Compound 10 
       1 H NMR (400 MHz, DMSO-d 6 ) δ ppm: 9.03 (s, 1H), 8.62 (d, J=1.0 Hz, 1H), 8.61 (s, 1H), 8.22 (d, J=5.4 Hz, 1H), 7.23 (d, J=5.4 Hz, 1H), 6.64 (s, 2H), 5.46 (s, 1H), 5.42-5.35 (m, 1H), 3.91 (t, J=7.6 Hz, 2H), 3.65-3.58 (m, 2H), 2.15-2.08 (m, 1H), 0.45-0.31 (m, 4H). 
     LCMS (Method E): R t =2.03 min, m/z [M+H] + =451. 
     Compound 11 
       1 H NMR (400 MHz, DMSO-d 6 ) δ ppm: 9.04 (s, 1H), 8.62 (s, 1H), 8.59 (s, 1H), 8.23 (d, J=5.4 Hz, 1H), 7.23 (d, J=5.4 Hz, 1H), 6.64 (s, 2H), 5.40-5.39 (m, 1H), 5.35 (s, 1H), 3.95-3.92 (m, 2H), 3.64-3.63 (m, 2H), 2.12 (s, 1H), 1.54 (s, 3H), 1.21-1.13 (m, 1H), 0.59-0.33 (m, 8H). 
     LCMS (Method E): R t =2.26 min, m/z [M+H] + =471. 
     Compound 12 
       1 H NMR (400 MHz, DMSO-d 6 ) δ ppm: 9.01-8.98 (m, 2H), 8.66 (d, J=1.0 Hz, 1H), 8.21 (d, J=5.4 Hz, 1H), 7.22 (d, J=5.4 Hz, 1H), 6.61 (s, 2H), 5.46 (s, 1H), 4.98-4.91 (m, 1H), 2.95-2.86 (m, 2H), 2.64-2.56 (m, 2H), 2.47-2.44 (m, 2H), 2.04-1.90 (m, 2H), 1.71-1.63 (m, 2H), 1.12 (t, J=7.1 Hz, 3H). 
     LCMS (Method E): R t =2.04 min, m/z [M+H] + =467. 
     Compound 13 
       1 H NMR (400 MHz, DMSO-d 6 ) δ ppm: 8.99 (d, J=0.9 Hz, 1H), 8.64 (d, J=1.0 Hz, 1H), 8.50 (s, 1H), 8.21 (d, J=5.5 Hz, 1H), 7.21 (d, J=5.4 Hz, 1H), 6.60 (s, 2H), 5.45 (s, 1H), 4.49-4.39 (m, 2H), 3.11-3.02 (m, 1H), 2.95-2.87 (m, 1H), 2.68-2.57 (m, 1H), 2.27-2.10 (m, 2H), 1.87-1.76 (m, 1H), 1.61-1.55 (m, 1H), 1.49-1.33 (m, 2H), 0.95 (t, J=7.1 Hz, 3H). 
     LCMS (Method E): R t =1.99 min, m/z [M+H] + =467. 
     Compound 14 
       1 H NMR (400 MHz, DMSO-d 6 ) δ ppm: 9.11 (d, J=0.9 Hz, 1H), 8.67 (s, 1H), 8.66 (d, J=1.0 Hz, 1H), 8.21 (d, J=5.5 Hz, 1H), 7.22 (d, J=5.5 Hz, 1H), 6.62 (s, 2H), 5.46 (s, 1H), 5.45-5.41 (m, 1H), 3.23-3.17 (m, 2H), 2.68-2.51 (m, 4H), 2.34-2.25 (m, 1H), 2.01-1.91 (m, 1H), 1.17 (t, J=7.2 Hz, 3H). 
     LCMS (Method E): R t =1.95 min, m/z [M+H] + =453. 
     Pharmacological Part 
     Biological Assay A 
     Inhibition of Auto-phosphorylation of Recombinant Human NF-kappaB-inducing Kinase (NIK/MAP3K14) Activity (AlphaScreen®) 
     NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreen® (αscreen) format (Perkin Elmer). All compounds tested were dissolved in dimethyl sulfoxide (DMSO) and further dilutions were made in assay buffer. Final DMSO concentration was 1% (v/v) in assays. Assay buffer was 50 mM Tris pH 7.5 containing 1 mM EGTA (ethylene glycol tetraacetic acid), 1 mM DTT (dithiothreitol), 0.1 mM Na 3 VO 4 , 5 mM MgCl 2 , 0.01% Tween® 20. Assays were carried out in 384 well Alphaplates (Perkin Elmer). Incubations consisted of compound, 25 microM Adenosine-5′-triphosphate (ATP), and 0.2 nM NIK/MAP3K14. Incubations were initiated by addition of GST-tagged NIK/MAP3K14 enzyme, carried out for 1 h at 25° C. and terminated by addition of stop buffer containing anti-phospho-IKK Ser176/180 antibody. Protein A Acceptor and Glutathione-Donor beads were added before reading using an EnVision® Multilabel Plate Reader (Perkin Elmer). Signal obtained in the wells containing blank samples was subtracted from all other wells and IC 50 &#39;s were determined by fitting a sigmoidal curve to % inhibition of control versus Log 10  compound concentration. 
     Biological Assay B 
     Effect of Compounds on P-IKKα Levels in L363 Cells 
     All compounds tested were dissolved in DMSO and further dilutions were made in culture medium. Final DMSO concentration was 1% (v/v) in cell assays. The human L363 cells (ATCC) were cultured in RPMI 1640 medium supplemented with GlutaMax and 10% fetal calf serum (PAA). Cells were routinely maintained at densities of 0.2×10 6  cells per ml-1×10 6  cells per ml at 37° C. in a humidified 5% C02 atmosphere. Cells were passaged twice a week splitting back to obtain the low density. Cells were seeded in 96 well plates (Nunc 167008) at 2×10 6  per ml media in a volume of 75 μl per well plus 25 μl 1 μg/ml recombinant human B-cell activating factor (BAFF/BLyS/TNFSF13B). Seeded cells were incubated at 37° C. in a humidified 5% CO 2  atmosphere for 24 hr. Drugs and/or solvents were added (20 μl) to a final volume of 120 μl. Following 2 hr treatment plates were removed from the incubator and cell lysis was achieved by the addition of 30 μl 5× lysis buffer followed by shaking on a plate shaker at 4° C. for 10 min. At the end of this incubation lysed cells were centrifuged at 800×g for 20 min at 4° C. and the lysate was assessed for P-IKKα levels by sandwich immuno-assay carried out in anti-rabbit antibody coated Mesoscale plates. Within an experiment, the results for each treatment were the mean of 2 replicate wells. 
     For initial screening purposes, compounds were tested using an 8 point dilution curve (serial 1:3 dilutions). For each experiment, controls (containing MG132 and BAFF but no test drug) and a blank incubation (containing MG132 and BAFF and 10 μM ADS 125117, a test concentration known to give full inhibition) were run in parallel. The blank incubation value was subtracted from all control and sample values. To determine the IC 50  a sigmoidal curve was fitted to the plot of % inhibition of control P-IKKα levels versus Log 10  compound concentration. 
     Biological Assay C 
     Determination of Antiproliferative Activity on LP-1, L-363 and JJN-3 Cells 
     All compounds tested were dissolved in DMSO and further dilutions were made in culture medium. Final DMSO concentration was 0.3% (v/v) in cell proliferation assays. 
     Viability was assessed using CellTiter-Glo cell viability assay kit (Promega). The human LP-1, L-363 and JJN-3 cells (DSMZ) were cultured in RPMI 1640 medium supplemented with 2 mM L-glutamine, and 10% fetal calf serum (PAA). Cells were routinely kept as suspension cells at 37° C. in a humidified 5% C02 atmosphere. Cells were passaged at a seeding density of 0.2×10 6 /ml twice a week. Cells were seeded in black tissue culture treated 96-well plates (Perkin Elmer). Densities used for plating ranged from 2,000 to 6,000 cells per well in a total volume of 75 μl medium. After twenty four hours, drugs and/or solvents were added (25 μl) to a final volume of 100 μl. Following 72 hr of treatment plates were removed from the incubator and allowed to equilibrate to room temperature for approx 10 min. 100 μl CellTiter-Glo reagent was added to each well that was then covered (Perkin Elmer Topseal) and shaken on plate shaker for 10 min. Luminescence was measured on a HTS Topcount (Perkin Elmer). Within an experiment, the results for each treatment were the mean of 2 replicate wells. 
     For initial screening purposes, compounds were tested using a 9 point dilution curve (serial 1:3 dilutions). For each experiment, controls (containing no drug) and a blank incubation (containing cells read at the time of compound addition) were run in parallel. The blank value was subtracted from all control and sample values. For each sample, the mean value for cell growth (in relative light units) was expressed as a percentage of the mean value for cell growth of the control. 
     Data for the compounds of the invention in the above assays are provided in Table 13 (the values in Table 13 are averaged values over all measurements on all batches of a compound). 
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 13 
               
               
                   
               
               
                   
                 Alpha- 
                 IKKα 
                   
                   
                   
               
               
                   
                 Screen 
                 Cellular 
                 JJN-3 
                 L-363 
                 LP-1 
               
               
                   
                 IC50 
                 IC 50   
                 EC 50   
                 EC 50   
                 EC 50   
               
               
                 Compound 
                 (nM) 
                 (nM) 
                 (nM) 
                 (nM) 
                 (nM) 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1 
                 15 
                 104 
                 764 
                 979 
                 2217 
               
               
                 2 
                 9 
                 339 
                 1470 
                 2798 
                 10276 
               
               
                 3 
                 140 
                 n.c. 
                 540 
                 258 
                 3984 
               
               
                 4 
                 26 
                 n.c. 
                 1735 
                 1578 
                 3126 
               
               
                 5 
                 19 
                  64 
                 299 
                 395 
                 1682 
               
               
                 6 
                 15 
                 n.c. 
                 580 
                 1037 
                 3431 
               
               
                 7 
                 32 
                 n.c. 
                 1062 
                 696 
                 &gt;30000 
               
               
                 8 
                 112 
                 n.c. 
                 16 
                 4 
                 38 
               
               
                 9 
                 20 
                 n.c. 
                 24 
                 7 
                 85 
               
               
                 10 
                 52 
                 n.c. 
                 494 
                 610 
                 1476 
               
               
                 11 
                 26 
                 n.c. 
                 652 
                 461 
                 918 
               
               
                 12 
                 66 
                 n.c. 
                 289 
                 243 
                 783 
               
               
                 13 
                 58 
                 n.c. 
                 60 
                 36 
                 75 
               
               
                 14 
                 38 
                 n.c. 
                 145 
                 122 
                 655 
               
               
                   
               
               
                 n.c. means not calculated 
               
            
           
         
       
     
     Prophetic Composition Examples 
     “Active ingredient” (a.i.) as used throughout these examples relates to a compound of Formula (I), including any tautomer or stereoisomeric form thereof, or a pharmaceutically acceptable addition salt, or a solvate thereof; in particular to any one of the exemplified compounds. 
     Typical examples of recipes for the formulation of the invention are as follows: 
     1. Tablets 
                                                    Active ingredient   5 to 50   mg           Di-calcium phosphate   20   mg           Lactose   30   mg           Talcum   10   mg           Magnesium stearate   5   mg           Potato starch   ad 200   mg                        
2. Suspension
 
     An aqueous suspension is prepared for oral administration so that each milliliter contains 1 to 5 mg of active ingredient, 50 mg of sodium carboxymethyl cellulose, 1 mg of sodium benzoate, 500 mg of sorbitol and water ad 1 ml. 
     3. Injectable 
     A parenteral composition is prepared by stirring 1.5 0 (weight/volume) of active ingredient in 0.9% NaCl solution or in 10% by volume propylene glycol in water. 
     4. Ointment 
     
       
         
           
               
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Active ingredient 
                 5 to 1000 
                 mg 
               
               
                   
                 Stearyl alcohol 
                 3 
                 g 
               
               
                   
                 Lanoline 
                 5 
                 g 
               
               
                   
                 White petroleum 
                 15 
                 g 
               
               
                   
                 Water 
                 ad 100 
                 g 
               
               
                   
                   
               
            
           
         
       
     
     In this Example, active ingredient can be replaced with the same amount of any of the compounds according to the present invention, in particular by the same amount of any of the exemplified compounds.