Patent Publication Number: US-2021186521-A1

Title: Adhesion device

Description:
CROSS-REFERENCES TO RELATED APPLICATIONS 
     This application is a continuation of International Patent Application No. PCT/JP2019/035278 filed on Sep. 6, 2019, which claims priority to Japanese Patent Application No. 2018-168298 filed on Sep. 7, 2018, the entire content of both of which is incorporated herein by reference. 
    
    
     FIELD OF THE INVENTION 
     The present disclosure generally relates to an adhesion device and method, more specifically a hemostasis method and a medical adhesion device for applying compression to a puncture site to perform hemostasis. 
     BACKGROUND DISCUSSION 
     In recent years, in the medical institutions, various forms of examinations or treatments are performed using a medical insertion device which has an elongated hollow tubular shape and is called a catheter. The catheter is percutaneously inserted into a blood vessel from a puncture site, which is formed in the wrist, the inguinal region, or the like, to be delivered to a site to be examined or treated through the blood vessel. After the examination or treatment by a health care worker is completed, the catheter or a sheath used to introduce the catheter is extracted from the puncture site, and hemostasis is performed on the puncture site. 
     JP-T-2005-521464 (PTL 1) discloses a dressing as an adhesion device including a compression member that compresses a wound of a patient after a sheath is extracted. The dressing described in this publication includes an inflatable bladder having a deflated state where a membrane is adjacent to an end wall and an inflated state where the membrane is spaced apart from the end wall. In addition, the dressing described in this publication includes holding means that holds the bladder against the skin of the patient at a position where the wound is substantially covered. The noted publication discloses the holding means including a flexible web that is connected to the end wall of the bladder to protrude outward from the end wall of the bladder, and a pressure-sensitive adhesion layer which is bonded to the skin of the patient is provided on one surface as an adhesion surface of the flexible web. During shipping and transportation, the pressure-sensitive adhesion layer is covered with a protective sheet which is removable. The protective sheet is removed before use. 
     In the dressing as an adhesion device described in the publication identified above, the pressure-sensitive adhesion layer provided on the one surface of the flexible web is bonded to the skin as a biological surface of the patient, and the bladder as a compression member is brought into an inflated state, so that the wound of the patient can be compressed by the bladder. 
     However, in the dressing described in the noted patent application publication, when the wound of the patient is compressed by the bladder, due to a depression of the skin by compression or reaction force received from the skin, the pressure-sensitive adhesion layer provided on the one surface of the flexible web is likely to peel off in the vicinity of the bladder. When the pressure-sensitive adhesion layer peels off, a desired compression force of the bladder may not be obtained. 
     In addition, even an adhesion device which does not include a compression member may be likely to peel off from the skin due to external force. 
     Further, the noted publication discloses the protective sheet as a release sheet which protects the pressure-sensitive adhesion layer of the adhesion surface; however, there is room for improvement in the configuration of the protective sheet. 
     SUMMARY 
     The adhesion device disclosed here is unlikely to peel off from a biological surface. Further, the adhesion device includes a release sheet that is easily released from an adhesion surface. 
     According to a first aspect of the present disclosure, there is provided an adhesion device including: an adhesion sheet that includes an adhesion surface that is adherable to a biological surface, and a mounting surface that is located on a side of the adhesion sheet opposite the adhesion surface, a device main body that is mounted to the mounting surface of the adhesion sheet, and a release sheet that is releasably adhered to the adhesion surface of the adhesion sheet. The adhesion sheet includes a first portion to which the device main body is mounted and a second portion to which the device main body is not mounted, and the release sheet includes a release layer that is adhered to the adhesion surface of the adhesion sheet, and a folded layer which is formed of at least one layer and is folded to a side, which is opposite to the adhesion surface with respect to the release layer. The folded layer of the release sheet is layered on the release layer of the release sheet at least at a position of the second portion of the adhesion sheet. 
     As one embodiment of the present disclosure, the folded layer of the release sheet forms a sheet grip portion that is gripped when the release sheet is released from the adhesion sheet. The sheet grip portion includes a designated grip portion. The designated grip portion includes at least one of an extending portion which is formed of a portion of the folded layer of the release sheet, the portion not overlapping the release layer in a plan view seen along a thickness direction of the adhesion sheet, and a grip guide portion which is a portion of the folded layer of the release sheet, the portion overlapping the release layer in the plan view seen along the thickness direction of the adhesion sheet, and to which a predetermined mark which provides a guide on gripping is applied. 
     According to one embodiment of the present disclosure, in the plan view seen along the thickness direction, at least one fold between the release layer and the folded layer of the release sheet passes through the first portion of the adhesion sheet. 
     In accordance with one embodiment of the present disclosure, in the plan view seen along the thickness direction, the device main body is interposed between a portion of the at least one fold and the designated grip portion of the sheet grip portion, the portion overlapping the first portion of the adhesion sheet. 
     According to one embodiment of the present disclosure, the device main body includes a holder that is fixed to the mounting surface of the adhesion sheet, and a compression member that is held by the holder and protrudes or is protrudable toward one side in the thickness direction from the adhesion surface of the adhesion sheet to compress the biological surface. In the plan view seen along the thickness direction, the holder is interposed between the portion of the at least one fold and the designated grip portion of the sheet grip portion, the portion overlapping the first portion of the adhesion sheet. 
     According to one embodiment of the present disclosure, the holder includes a cover portion that covers the other side of the compression member in the thickness direction, and a support portion that supports the cover portion, and is fixed to the mounting surface of the adhesion sheet. In the plan view seen along the thickness direction, the support portion of the holder is interposed between the portion of the at least one fold and the designated grip portion of the sheet grip portion, the portion overlapping the first portion of the adhesion sheet. 
     In accordance with one embodiment of the present disclosure, in the plan view seen along the thickness direction, the support portion extends to surround the cover portion. In the plan view seen along the thickness direction, a part of the support portion extends from the portion of the fold in a direction toward the designated grip portion of the sheet grip portion, the portion overlapping the first portion of the adhesion sheet. 
     In accordance with one embodiment of the present disclosure, the adhesion sheet includes an outer peripheral portion that is located on a periphery outside the device main body in the plan view seen along the thickness direction. In the plan view seen along the thickness direction, the outer peripheral portion of the adhesion sheet does not fully surround the periphery of the device main body, and a receiving portion configured to receive an insertion device is defined around the device main body at a position where the outer peripheral portion of the adhesion sheet is not provided. In the plan view seen along the thickness direction, the designated grip portion of the sheet grip portion is formed at a position different from a position of the receiving portion. 
     In one embodiment of the present disclosure, in the plan view seen along the thickness direction, the release sheet is not provided in at least a part of the receiving portion. 
     According to one embodiment of the present disclosure, in the plan view seen along the thickness direction, the adhesion sheet extends to surround the cover portion. A gap leading to an outside is formed in the adhesion sheet and the support portion at the same position of a part of a periphery surrounding the cover portion in the plan view seen along the thickness direction. A receiving portion configured to receive an insertion device is formed of the gap. 
     In one embodiment of the present disclosure, in the plan view seen along the thickness direction, the release sheet is located at the gap, and has a split at a position of the gap. 
     According to the present disclosure, it is possible to provide the adhesion device that is unlikely to peel off from the biological surface. Further, according to the present disclosure, it is possible to provide the adhesion device including the release sheet that is easily released from the adhesion surface. 
     According to another aspect, an adhesion device comprises: an adhesion sheet that includes oppositely facing surfaces, one of the oppositely facing surfaces being a mounting surface, an other of the oppositely facing surfaces being an adhesion surface on which is provided an adhesive that is adherable to a biological surface; a device main body; and a release sheet. The adhesion device main body includes a support portion fixed to the mounting surface of the adhesion sheet so that when the adhesion surface of the adhesion sheet is adhered to the biological surface the device main body is fixed in position on the biological surface. The device main body also includes a part that is supported by the support portion and that is configured to interact with the biological surface when the device main body is fixed in position on the biological surface by virtue of the adhesion surface of the adhesion sheet being adhered to the biological surface. The support portion of the device main body includes a periphery, and the adhesion sheet extends beyond the periphery of the support portion in a plan view seen along a thickness direction of the adhesion sheet. The release sheet is releasably adhered to the adhesion surface of the adhesion sheet so that the release sheet covers an entirety of the adhesion surface. The release sheet is releasable from the adhesion surface so that the release sheet is removable from the adhesion sheet to expose the adhesive and allow the adhesive to be adhered to the biological surface. The adhesion sheet includes a first portion and a second portion, with the support portion of the device main body being fixed to the mounting surface of the adhesion sheet along the first portion of the adhesion sheet, and the support portion of the device main body not being fixed to the mounting surface of the adhesion sheet along the second portion of the adhesion sheet. The release sheet includes a release layer and a folded layer, with the release layer having a surface that is adhered to the adhesion surface of the adhesion sheet, and the folded layer being comprised of at least one layer and being folded to a side of the release sheet opposite the adhesion sheet. The folded layer of the release sheet and the release layer of the release sheet overlie one another at least at a position of the second portion of the adhesion sheet. 
     In accordance with another aspect, a method comprises: holding an adhesive device that comprises an adhesion sheet, a device main body and a release sheet. The adhesion sheet includes an adhesion surface on one side of the adhesion sheet and a mounting surface on an opposite side of the adhesion sheet, with the device main body being fixed to the mounting surface of the adhesion sheet along a first portion of the adhesion sheet, and the device main body not being fixed to the mounting surface of the adhesion sheet along a second portion of the adhesion sheet. The release sheet includes a release layer and a folded layer, wherein the release layer of the release sheet is releasably adhered to the adhesion surface of the adhesion sheet, and the folded layer is folded to a side opposite the adhesion surface with respect to the release layer. The folded layer and the release layer of the release sheet overlie one another at a position of the second portion of the adhesion sheet. The method additionally involves, removing the release sheet from the adhesion sheet to expose the adhesion surface, and pressing the exposed adhesion surface against a biological surface to adhere the adhesion device to the biological surface. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  is a perspective view of an adhesion device in a first embodiment. 
         FIG. 2  is an exploded perspective view of the adhesion device illustrated in  FIG. 1 . 
         FIG. 3A  is a side view of the adhesion device illustrated in  FIG. 1 . 
         FIG. 3B  is a side view of the adhesion device illustrated in  FIG. 1  as seen in a direction different from that of  FIG. 3A . 
         FIG. 4A  is a perspective view illustrating a state where a release sheet is removed from the adhesion device illustrated in  FIG. 1 . 
         FIG. 4B  is a top view in the state illustrated in  FIG. 4A . 
         FIG. 4C  is a bottom view in the state illustrated in  FIG. 4A . 
         FIG. 5  is a view illustrating the release sheet of the adhesion device illustrated in  FIG. 1 , and is a view illustrating a method of forming the release sheet. 
         FIG. 6  is a top view of the adhesion device illustrated in  FIG. 1 . 
         FIG. 7  is a bottom view of the adhesion device illustrated in  FIG. 1 . 
         FIG. 8A  is a side view in the state illustrated in  FIG. 4A , and illustrates a state of a compression member before inflated. 
         FIG. 8B  is a side view in the state illustrated in  FIG. 4A , and illustrates a state of the compression member after inflated. 
         FIG. 9  is a flowchart illustrating a compression method using the adhesion device illustrated in  FIG. 1 . 
         FIG. 10A  is a view illustrating an outline of an alignment step in a mounting step of  FIG. 9 . 
         FIG. 10B  is a view illustrating an outline of the alignment step in the mounting step of  FIG. 9 . 
         FIG. 10C  is a view illustrating an outline of a release sheet removing step in the mounting step of  FIG. 9 . 
         FIG. 10D  is a view illustrating an outline of the release sheet removing step in the mounting step of  FIG. 9 . 
         FIG. 10E  is a view illustrating an outline of an adhesion step in the mounting step of  FIG. 9 . 
         FIG. 10F  is a view illustrating an outline of a first compression step of  FIG. 9 . 
         FIG. 10G  is a view illustrating an outline of an extraction step of  FIG. 9 . 
         FIG. 10H  is a view illustrating an outline of a second compression step of  FIG. 9 . 
         FIG. 11  is a top view of an adhesion device in a second embodiment. 
         FIG. 12  is a bottom view of the adhesion device illustrated in  FIG. 11 . 
         FIG. 13A  is a side view of the adhesion device illustrated in  FIG. 11 . 
         FIG. 13B  is a side view of the adhesion device illustrated in  FIG. 11  as seen in a direction different from that of  FIG. 13A . 
         FIG. 14  is a view illustrating a release sheet of the adhesion device illustrated in  FIG. 11 , and is a view illustrating a method of forming the release sheet. 
         FIG. 15  is a perspective view of the release sheet of the adhesion device illustrated in  FIG. 11 . 
         FIG. 16  is a perspective view of an adhesion device in a third embodiment. 
         FIG. 17  is an exploded perspective view of the adhesion device illustrated in  FIG. 16 . 
         FIG. 18  is a top view of the adhesion device illustrated in  FIG. 16 . 
         FIG. 19  is a bottom view of the adhesion device illustrated in  FIG. 16 . 
         FIG. 20  is a view illustrating a release sheet of the adhesion device illustrated in  FIG. 16 , and is a view illustrating a method of forming the release sheet. 
         FIG. 21  is a perspective view of an adhesion device in a fourth embodiment. 
         FIG. 22  is an exploded perspective view of the adhesion device illustrated in  FIG. 21 . 
         FIG. 23  is a top view of the adhesion device illustrated in  FIG. 21 . 
         FIG. 24  is a bottom view of the adhesion device illustrated in  FIG. 21 . 
         FIG. 25  is a view illustrating a release sheet of the adhesion device illustrated in  FIG. 21 , and is a view illustrating a method of forming the release sheet. 
         FIG. 26  is a perspective view of an adhesion device in a fifth embodiment. 
         FIG. 27  is an exploded perspective view of the adhesion device illustrated in  FIG. 26 . 
         FIG. 28  is a top view of the adhesion device illustrated in  FIG. 26 . 
         FIG. 29  is a bottom view of the adhesion device illustrated in  FIG. 26 . 
         FIG. 30  is a view illustrating a release sheet of the adhesion device illustrated in  FIG. 26 , and is a view illustrating a method of forming the release sheet. 
         FIG. 31  is a description view describing when external force in a direction orthogonal to a biological surface is applied to a device main body in a state where the adhesion device illustrated in  FIG. 1  adheres to the biological surface. 
         FIG. 32A  is a view illustrating a state where an insertion device is inserted into a femoral vein from the biological surface through a connective tissue. 
         FIG. 32B  is a view illustrating a state of the insertion device after extracted from the state illustrated in  FIG. 32A . 
         FIG. 33  is a view illustrating a modification example of the release sheet illustrated in  FIG. 1 , and is a view illustrating a method of forming the release sheet in the modification example. 
         FIG. 34  is a view illustrating another modification example of the release sheet illustrated in  FIG. 1 , and is a view illustrating a method of forming the release sheet in the modification example. 
         FIG. 35  is a perspective view illustrating an adhesion device to which the release sheet illustrated in  FIG. 34  adheres. 
     
    
    
     DETAILED DESCRIPTION 
     Set forth below with reference to the accompanying drawings is a detailed description of embodiments of an adhesion device representing examples of the inventive adhesion device disclosed here. The dimensions or scales on the drawings may be exaggerated or different from actuality/reality for convenience of description and illustration. 
     First Embodiment 
       FIG. 1  is a perspective view of a medical adhesion device  1  in a first embodiment of the present disclosure.  FIG. 2  is an exploded perspective view of the adhesion device  1 .  FIGS. 3A and 3B  are side views of the adhesion device  1  as seen in different directions. 
     As illustrated in  FIGS. 1 to 3 , the adhesion device  1  includes an adhesion sheet  2 , a device main body  3 , and a release sheet  4 . 
     The adhesion sheet  2  includes an adhesion surface  11  that is adherable to a biological surface, and a mounting surface  12  that is located on a side opposite to the adhesion surface  11 . The adhesion surface  11  is located on one side in a thickness direction A of the adhesion sheet  2 . The mounting surface  12  is located on the other or opposite side of the adhesion sheet  2  in the thickness direction A. 
     The device main body  3  is mounted to the mounting surface  12  of the adhesion sheet  2 . The configuration of the device main body  3  is not particularly limited. The device main body  3  of the present embodiment includes a compression member  22  (refer to  FIG. 8B ) to be described later which can compress the biological surface, but is not limited to the configuration with the compression member  22 . Details of an example of the compression member  22  will be described later. 
     The release sheet  4  releasably adheres to the adhesion surface  11  of the adhesion sheet  2 . The “adhesion” is one aspect of “mounting”, and the “mounting” is not limited to adhesion. 
       FIG. 4A  is a perspective view illustrating a state where the release sheet  4  is released from the adhesion device  1  illustrated in  FIGS. 1 to 3 .  FIG. 4B  is a plan view of the state illustrated in  FIG. 4A  as seen from a mounting surface  12  side of the adhesion sheet  2 .  FIG. 4C  is a plan view of the state illustrated in  FIG. 4A  as seen from an adhesion surface  11  side of the adhesion sheet  2 . The adhesion surface  11  adheres to the biological surface, so that the position of the adhesion device  1  on the biological surface is fixed. When the adhesion device  1  is to be adhered to the biological surface, the release sheet  4  is released or removed from the adhesion surface  11 . Accordingly, the adhesion surface  11  of the adhesion sheet  2  is exposed to the outside, and the adhesion device  1  is in the state of being able to adhere to the biological surface. 
     Hereinafter, for convenience of description, a state where the release sheet  4  adheres to the adhesion surface  11  of the adhesion sheet  2  (refer to  FIGS. 1 to 3 ) may be simply referred to as a “pre-use state”, and a state where the release sheet  4  is removed from the adhesion surface  11  of the adhesion sheet  2  (refer to  FIG. 4 ) may be simply referred to as a “use state”. 
     Hereinafter, for convenience of description, in the adhesion device  1 , the one side in the thickness direction A, which is a direction from the mounting surface  12  toward the adhesion surface  11  in the thickness direction A of the adhesion sheet  2 , is simply referred to as a “downward direction A 1 ”. In addition, for convenience of description, in the adhesion device  1 , the other side in the thickness direction A, which is a direction from the adhesion surface  11  toward the mounting surface  12  in the thickness direction A of the adhesion sheet  2 , is simply referred to as an “upward direction A 2 ”. Therefore, the adhesion surface  11  of the adhesion sheet  2  of the present embodiment is formed of a lower surface of the adhesion sheet  2 . In addition, the mounting surface  12  of the adhesion sheet  2  of the present embodiment is formed of an upper surface of the adhesion sheet  2 . 
     As illustrated in  FIGS. 4B and 4C  and the like, the adhesion sheet  2  includes a first portion X 1  to which the device main body  3  is mounted, and a second portion X 2  to which the device main body  3  is not mounted. The “first portion X 1 ” means a portion of the adhesion sheet  2 , which overlaps the device main body  3  in the thickness direction A, and a portion of the adhesion sheet  2 , which is not separable from the device main body  3  in the thickness direction A. In addition, the “second portion X 2 ” means both (i) a portion of the adhesion sheet  2 , which does not overlap the device main body  3  in the thickness direction A, and (ii) a portion of the adhesion sheet  2 , which overlaps the device main body  3  in the thickness direction A, and a portion of the adhesion sheet  2 , which is separable from the device main body  3  in the thickness direction A. Therefore, for example, a portion of the adhesion sheet  2 , which is simply covered with the device main body  3  but is separable therefrom in the thickness direction A, corresponds to the second portion X 2 . Although details will be described later, since the adhesion sheet  2  includes not only the first portion X 1  but also the second portion X 2 , the adhesion device  1  can be suppressed from being unintentionally released from the biological surface (refer to  FIG. 31 ). 
     In addition, as illustrated in  FIGS. 1 to 3 , the release sheet  4  includes a release layer  4   a  that adheres to the adhesion surface  11  of the adhesion sheet  2 , and a folded layer  4   b  which is formed of at least one layer (in the present embodiment, a part of the folded layer  4   b  is in three layers and the other part of the folded layer  4   b  is in one layer) and is folded to a side, which is opposite to the adhesion surface  11  with respect to the release layer  4   a , to be layered. 
     As illustrated in  FIG. 1 , the folded layer  4   b  of the release sheet  4  is layered on the release layer  4   a  of the release sheet  4  (the folded layer  4   b  and the release layer  4   a  overlie one another) at least at the position of the second portion X 2  of the adhesion sheet  2 . Since the release sheet  4  has such a configuration, the release sheet  4  is easily released from the second portion X 2  of the adhesion sheet  2 . The release sheet  4  can be released from the adhesion sheet  2  by moving the folded layer  4   b  in an extending direction B of the adhesion sheet  2 , which is orthogonal to the thickness direction A of the adhesion sheet  2 . For this reason, as compared to a configuration without the folded layer  4   b , when the release sheet  4  is released from the adhesion sheet  2 , it is more difficult to apply force to the adhesion sheet  2  in the thickness direction A which is an out-of-plane direction of the adhesion sheet  2 . On the other hand, it is easy to apply force to the adhesion sheet  2  in the extending direction B which is an in-plane direction of the adhesion sheet  2 . Accordingly, when the release sheet  4  is released from the adhesion sheet  2 , the second portion X 2  of the adhesion sheet  2 , which is not mounted to the device main body  3 , can be suppressed from being bent together with the release sheet  4 . 
     Therefore, since the adhesion sheet  2  includes the second portion X 2  as described above, the adhesion device  1  is unlikely to peel off from the biological surface. Further, in the adhesion device  1 , the release sheet  4  includes the folded layer  4   b  in the second portion X 2  of the adhesion sheet  2 . For this reason, the release sheet  4  is easily released from the adhesion surface  11  even in the second portion X 2  of the adhesion sheet  2 . 
       FIG. 5  is a view illustrating the release sheet  4  of the adhesion device  1 .  FIG. 5  illustrates a method of forming the release sheet  4 . As illustrated in  FIG. 2  and the like, in the present embodiment, the entire region of the adhesion surface  11  of the adhesion sheet  2  is covered with two release sheets  4  which are symmetrical in shape.  FIG. 5  illustrates only one release sheet  4  of the two release sheets  4  which are symmetrical in shape. Since the two release sheets  4  are symmetrical in shape, hereinafter, only the one release sheet  4  will be described as an example. 
     As illustrated in  FIG. 5 , the release sheet  4  of the present embodiment is folded once from an original form of a single layer (left figure in  FIG. 5 ) to be shaped into an intermediate form of two layers (middle figure in  FIG. 5 ). Further, the release sheet  4  of the present embodiment is further partially folded from the intermediate form of two layers to be shaped into a completed form (right figure in  FIG. 5 ) in which a part is in four layers and the other part is in two layers. In such a manner, the release sheet  4  including the release layer  4   a  which is formed of one layer and the folded layer  4   b  of which a part is formed of three layers and the other part is formed of one layer is formed. 
     The configuration of the release layer  4   a  and the folded layer  4   b  of the release sheet  4  is not limited to the configuration illustrated in  FIG. 5 . In the present embodiment, the release sheet  4  is used in the completed form illustrated in  FIG. 5  (right figure in  FIG. 5 ); however, for example, the release sheet may be used in the intermediate form illustrated in  FIG. 5  (middle figure in  FIG. 5 ). In the present embodiment, the release sheet  4  is partially folded from the intermediate form illustrated in  FIG. 5  to be shaped into the completed form, so that a receiving portion  14  (refer to  FIG. 1  and the like) which can receive an insertion device such as a sheath is secured. Details of the receiving portion  14  will be described later. In addition, examples of release sheets having shapes different from that of the release sheet  4  of the present embodiment will be also described later (refer to  FIGS. 14, 15, 20, 25, and 30 ). 
     Further, in the present embodiment, as illustrated in  FIG. 2  and the like, the two release sheets  4  are mounted to the adhesion surface  11  of one adhesion sheet  2 ; however, the entire region of the adhesion surface  11  of the adhesion sheet  2  may be covered with one release sheet, or may be covered with three or more release sheets (refer to  FIGS. 21 to 25 ). 
     As described above, the folded layer  4   b  of the release sheet  4  forms a sheet grip portion that is gripped when the release sheet  4  is released from the adhesion sheet  2 . The folded layer  4   b  as the sheet grip portion may include only a portion that overlaps the release layer  4   a  in the thickness direction A. It is preferable that the sheet grip portion includes a designated grip portion. As illustrated in  FIG. 1  and the like, the sheet grip portion of the present embodiment includes an extending portion  50  that is formed of a portion of the folded layer  4   b  of the release sheet  4 , the portion not overlapping the release layer  4   a  in a plan view seen along the thickness direction A of the adhesion sheet  2 . That is, in the illustrated embodiment, the sheet grip portion includes the extending portion  50  which may be a portion of the folded layer  4   b  of the release sheet  4  that is located outwardly beyond the outer periphery of the release layer  4   a  in a plan view seen along the thickness direction A of the adhesion sheet  2 . The designated grip portion of the sheet grip portion of the present embodiment is formed of the extending portion  50 . Since the sheet grip portion includes the extending portion  50  as a designated grip portion, the operability of releasing the release sheet  4  from the adhesion sheet  2  can be improved. The extending portion  50  of the present embodiment is located outside the adhesion sheet  2  and the device main body  3  in a plan view seen along the thickness direction A of the adhesion sheet  2 . Further, the extending portion  50  of the present embodiment is located outside the release layer  4   a  in a plan view seen along the thickness direction A of the adhesion sheet  2 . 
     In addition,  FIG. 33  is a view illustrating a release sheet  504  as a modification example of the release sheet  4  illustrated in  FIGS. 1 to 5 .  FIG. 33  illustrates a method of forming the release sheet  504 . A folded layer  504   b  of the release sheet  504  illustrated in  FIG. 33  includes a grip guide portion  550  which is a portion overlapping a release layer  504   a  in a plan view seen along the thickness direction A of the adhesion sheet  2 , and to which a predetermined mark  550   a  which provides a guide on gripping is applied. In the example illustrated in  FIG. 33 , a designated grip portion of the sheet grip portion is formed of the grip guide portion  550 . Examples of the mark  550   a  include various symbols, patterns, characters, combinations thereof, and the like which guide or visually indicate that the grip guide portion  550  is to be gripped to release the release sheet  504 . In addition, the mark  550   a  may include various symbols such as arrows, characters, and the like that also guide or visually indicate a direction in which the grip guide portion  550  is to be moved when the release sheet  504  is released, in addition to simply providing a guide on gripping. The grip guide portion  550  illustrated in  FIG. 33  provides a guide or visual indication on gripping with a line indicating a grip range, and guides the direction, in which the grip guide portion  550  is to be moved when the release sheet  504  is released, with an arrow. Namely, the mark  550   a  which is formed of a line and an arrow is applied to the grip guide portion  550  illustrated in  FIG. 33 . 
     As described above, the designated grip portion of the sheet grip portion may be the extending portion  50  described above (refer to  FIG. 5  and the like), or may be the grip guide portion  550  (refer to  FIG. 33 ). In  FIG. 33 , the extending portion is not provided; however, a configuration in which the extending portion is provided in addition to the grip guide portion  550  may be employed. In addition, in  FIG. 5 , the grip guide portion is not provided; however, a configuration in which the grip guide portion is provided in addition to the extending portion  50  may be employed. In addition, a mark which provides a guide or visual indication on gripping or a mark which guides the movement direction when the release sheet  4  is released may be applied to the extending portion  50  as the designated grip portion illustrated in  FIGS. 1 to 5 . 
     Hereinafter, each member and portion of the adhesion device  1  of the present embodiment will be described in further detail. 
     &lt;Adhesion Sheet  2 &gt; 
     The adhesion sheet  2  is flexible. Namely, the adhesion sheet  2  is easily deformable in the out-of-plane direction. For this reason, the adhesion sheet  2  is deformable along the shape of the biological surface. In addition, since the adhesion surface  11  adheres to the biological surface, the adhesion sheet  2  is easily deformed according to deformation of the biological surface so that the adhesion sheet conforms to the biological surface. As a result, the adhesion surface  11  is unlikely to peel off from the biological surface, and the adhesion device  1  can be suppressed from being unintentionally released from the biological surface. 
     Means for mounting the device main body  3  to the mounting surface  12  of the adhesion sheet  2  is not particularly limited. The device main body  3  and the mounting surface  12  of the adhesion sheet  2  may be joined, for example, by bonding using a bonding agent, fusion, adhesion, or the like. The release strength of the device main body  3  with respect to the mounting surface  12  of the adhesion sheet  2  is larger than at least the release strength of the release sheet  4  with respect to the adhesion surface  11  of the adhesion sheet  2 . The “release strength” referred to here can be measured, for example, by a 180° release test of the adhesion sheet  2 . 
     The adhesion sheet  2  includes a plurality of layers including, for example, a base material layer and a bonding layer. 
     The base material layer is made of, for example, a thin resin sheet. More specifically, the base material layer of the present embodiment is made of a white spunlace non-woven fabric of polyester fibers, and the thickness of the base material layer is in a range of 5 μm to 150 μm, for example, 30 μm or the like. The material of the base material layer is not limited to polyester, and for example, acrylic polymer, polyethylene, ethylene-vinyl acetate copolymer, polyurethane, polyamide derivative, or the like may be used. 
     The bonding layer is formed of a bonding agent such as a rubber-based bonding agent, an acrylic-based bonding agent, a silicon-based bonding agent, or the like. The bonding layer is laminated on the base material layer directly or indirectly with another layer interposed therebetween. The adhesion surface  11  of the adhesion sheet  2  of the present embodiment is formed of the bonding layer. 
     As described above, the adhesion sheet  2  of the present embodiment is made of a non-woven fabric tape, to one surface of which a pressure-sensitive adhesive is applied as a bonding agent, but may be made of a double sided tape in which bonding layers are provided on both sides of a base material layer. When the adhesion sheet is made of a double sided tape, the device main body  3  is bonded to one bonding layer of the adhesion sheet, so that the device main body  3  can be fixed to the adhesion sheet. 
     The adhesion sheet  2  is not limited to a structure of two layers including the base material layer and the bonding layer, and may have, for example, a structure of three or more layers further including another layer. The adhesion sheet may include, for example, a base material layer, a bonding layer, and a surface layer. For example, the surface layer is laminated, directly or indirectly with another layer interposed between the surface layer and the base layer, on an opposite side of the base material layer from the bonding layer with the base material layer interposed therebetween. Namely, the surface layer forms a mounting surface of the adhesion sheet. Since such a surface layer is provided, the mechanical strength can be adjusted. For example, the surface layer may be bonded with another bonding layer intervening between the base material layer and the surface layer. The surface layer can be made of, for example, a resin having a thickness of approximately 5 μm to 50 μm. More specifically, as the material of the surface layer, polyester, polyimide, polyamideimide, polyethylene, polypropylene, polycarbonate, polyurethane, polyvinyl chloride, fluororesin, and the like can be used. 
       FIGS. 6 and 7  are plan views of the adhesion device  1  as seen along the thickness direction A of the adhesion sheet  2 . More specifically,  FIG. 6  is a plan view of the adhesion device  1  as seen from the mounting surface  12  side of the adhesion sheet  2 , to which the device main body  3  is mounted.  FIG. 7  is a plan view of the adhesion device  1  as seen from the adhesion surface  11  side of the adhesion sheet  2 , to which the release sheet  4  is mounted. Hereinafter, for convenience of description, a plan view of the adhesion device  1  seen along the thickness direction A of the adhesion sheet  2  (refer to  FIGS. 4B, 4C, 6, and 7 ) is simply referred to as a “plan view”. In addition, among plan views of the adhesion device  1 , a plan view of the adhesion device  1  seen from the mounting surface  12  side of the adhesion sheet  2  (refer to  FIGS. 4B and 6 ) may be simply referred to as a “top view”. In addition, among the plan views of the adhesion device  1 , a plan view of the adhesion device  1  seen from the adhesion surface  11  side of the adhesion sheet  2  (refer to  FIGS. 4C and 7 ) may be simply referred to as a “bottom view”. 
     As illustrated in  FIG. 4B  and the like, in a plan view, the adhesion sheet  2  extends in a C shape. In other words, in a plan view, the adhesion sheet  2  of the present embodiment defines a central opening region. An open region of the central opening region forms the receiving portion  14  to be described later, the open region communicating with the outside. The open region in the central opening region is a region that is interposed between both end portions of the adhesion sheet  2  having a C shape in a plan view. 
     As described above, the outer shape of the adhesion sheet  2  of the present embodiment is a C shape in a plan view, but is not limited to this shape. For example, an adhesion sheet having an endless outer shape in a plan view may be used. The outer edge shape and the inner edge shape of the adhesion sheet having an endless outer shape in a plan view are not particularly limited. Various shapes such as polygonal shapes including a circular shape, an elliptical shape, and a quadrilateral shape can be employed. 
     In addition, if the adhesion sheet having an endless outer shape in a plan view is employed, it is preferable that a slit extends from an outer edge to an inner edge is formed in the adhesion sheet. Since such a slit is provided, the central opening region and the outside communicate with each other through the slit. For this reason, the insertion device such as a catheter or a sheath can be moved from outside the adhesion sheet to the central opening region through the slit. As described above, the slit may form the receiving portion  14 . 
     Next, the first portion X 1  and the second portion X 2  of the adhesion sheet  2  will be described. 
     As described above, the adhesion sheet  2  includes the first portion X 1  to which the device main body  3  is mounted, and the second portion X 2  to which the device main body  3  is not mounted (refer to  FIG. 1  and the like). More specifically, the adhesion sheet  2  includes the second portion X 2  that extends continuously from the first portion X 1 . An adhesion portion formed of a bonding agent or the like is provided in at least a part of the adhesion surface  11  at a position corresponding to the second portion X 2 . 
     Since the adhesion sheet  2  of the adhesion device  1  includes the second portion X 2  described above, the adhesion sheet  2  can be suppressed from unintentionally peeling off from the biological surface. Hereinafter, the details will be described. 
     The device main body  3  is mounted to the mounting surface  12  of the adhesion sheet  2 . For this reason, the adhesion device  1  is likely to receive external force even in a state where the adhesion device  1  adheres to the biological surface.  FIG. 31  illustrates a state where external force in a direction orthogonal to a biological surface BS is applied to the device main body  3  in a state where the adhesion surface  11  of the adhesion sheet  2  adheres to the biological surface BS. As illustrated in  FIG. 31 , when the external force in the direction orthogonal to the biological surface BS is applied to the device main body  3 , the first portion X 1  of the adhesion sheet  2  to which the device main body  3  is mounted is lifted in a direction away from the biological surface BS. Accordingly, a portion of the biological surface BS, to which the first portion X 1  adheres, is deformed to be lifted according to the first portion X 1 . Even when the above-described deformation occurs in the biological surface BS, the second portion X 2  extending from the first portion X 1  maintains the state of adhesion according to the biological surface BS. For this reason, force in a direction along a raised portion of the adhesion surface  11  and the biological surface BS is likely to be applied to the second portion X 2  extending from the first portion X 1 . 
     Namely, the application of the force in the direction orthogonal to the biological surface to the second portion X 2  extending from the first portion X 1  can be reduced. In addition, shearing force in a direction along the biological surface BS is likely to be applied to the second portion X 2  of the adhesion sheet  2 . The adhesion sheet  2  is unlikely to be moved and peeled off by the shearing force in the direction along the biological surface BS. As described above, since the adhesion sheet  2  is provided with the second portion X 2 , it is possible to realize the adhesion sheet  2  which is more unlikely to peel off from the biological surface BS as compared to a configuration without the second portion X 2 . 
     Particularly, as in the present embodiment, when the adhesion device  1  is a compression device, it is preferable that the adhesion sheet  2  includes not only the first portion X 1  but also the second portion X 2 . Although details will be described later, the adhesion device  1  of the present embodiment is a compression device including the compression member  22  (refer to  FIG. 8B ). Namely, in the adhesion device  1  of the present embodiment, the compression member  22  can compress a predetermined site on the biological surface in a state where the adhesion surface  11  adheres to the biological surface. Examples of the predetermined site on the biological surface, which is compressed by the adhesion device  1 , include a wound and the vicinity of the wound formed by insertion of a medical insertion device such as a puncture needle, a catheter, or a sheath into a blood vessel of a living body. After the above-described insertion device such as a sheath is extracted from the living body, the wound or the vicinity of the wound on the biological surface is compressed by the compression member  22  of the adhesion device  1 , so that hemostasis can be achieved. Since the adhesion surface  11  of the adhesion sheet  2  adheres to the biological surface, the device main body  3  including the compression member  22  can maintain a state where the biological surface is compressed. In other words, a compression force from the compression member  22  to the biological surface is applied at the position of the first portion X 1  of the adhesion sheet  2  as a force to lift the adhesion surface  11  to the upward direction A 2  in the thickness direction A. Namely, as illustrated in  FIG. 31 , a force to pull the first portion X 1  of the adhesion sheet  2  in a direction away from the biological surface BS is likely to be generated. For this reason, when the adhesion device  1  is a compression device, it is particularly preferable that the adhesion sheet  2  includes not only the first portion X 1  but also the second portion X 2 . 
     Further, as illustrated in  FIG. 7 , it is preferable that the second portion X 2  of the adhesion sheet  2  is provided on at least a compression member  22  side with respect to the first portion X 1 . A compression member  22  side of the first portion X 1  of the adhesion sheet  2  is more likely to be released due to the compression force of the compression member  22  as compared to a side opposite to the compression member  22  side. For this reason, the second portion X 2  is provided on at least the compression member  22  side with respect to the first portion X 1 , so that release of the adhesion sheet  2  can be more reliably suppressed. 
     As illustrated in  FIG. 7 , it is preferable that the second portion X 2  of the adhesion sheet  2  is provided not only on the compression member  22  side with respect to the first portion X 1  but also on the side opposite to the compression member  22  side. As a consequence, release of the adhesion sheet  2  can be even further suppressed. 
     Further, as illustrated in  FIG. 6  and the like, the adhesion sheet  2  of the present embodiment includes an outer peripheral portion  13  that is located on a periphery outside the device main body  3  in a plan view. In other words, the outer peripheral portion  13  of the adhesion sheet  2  of the present embodiment is the second portion X 2  that is not mounted to the device main body  3 , and this outer peripheral portion  13  of the adhesion sheet  2  is located outwardly of the outer periphery of the device main body  3  in a plan view. 
     As illustrated in  FIG. 6 , in the present embodiment, in a plan view, the outer peripheral portion  13  of the adhesion sheet  2  does not fully surround the periphery of the device main body  3 . Namely, a position where the outer peripheral portion  13  of the adhesion sheet  2  is not provided exists around the device main body  3 . A portion of the insertion device such as a sheath which is inserted into the living body is received at the position where the outer peripheral portion  13  of the adhesion sheet  2  is not provided, the portion extending outside the living body. Namely, the receiving portion  14  which can receive the insertion device such as a sheath is defined around the device main body  3  at the position where the outer peripheral portion  13  of the adhesion sheet  2  is not provided. In other words, as shown for example in  FIGS. 1 and 2 , the adhesion sheet  2  is discontinuous (the annular shape is interrupted), and the part where the adhesion sheet is not provided coincides with the receiving portion  14  of the device main body  3 . Accordingly, the compression member  22  of the device main body  3  can be brought close to the wound or the vicinity of the wound on the biological surface, the wound being formed by the insertion device such as a sheath. For this reason, after the insertion device such as a sheath is extracted from the living body, the wound or the vicinity of the wound on the biological surface is easily compressed by the compression member  22  of the device main body  3  of the adhesion device  1 . 
     &lt;Device Main Body  3 &gt; 
     As described above, the adhesion device  1  of the present embodiment is a compression device. Here, the device main body  3  including the compression member  22  will be described as an example; however, a device main body without the compression member  22  may be used. 
     As illustrated in  FIG. 4B  and the like, in a plan view, the device main body  3  of the present embodiment is disposed across the contour of the adhesion sheet  2 . In other words, in a plan view, the device main body  3  includes a portion that overlaps the adhesion sheet  2 , and a portion that does not overlap the adhesion sheet  2 . More specifically, in a plan view, the device main body  3  of the present embodiment is disposed to cover the central opening region of the adhesion sheet  2 . The device main body  3  of the present embodiment is fixed to the mounting surface  12  of the adhesion sheet  2  at the position of an outer edge portion of the device main body  3 . In the device main body  3  of the present embodiment, the compression member  22  to be described later can compress the biological surface in the central opening region defined by the adhesion sheet  2 . 
       FIGS. 8A and 8B  are side views of the adhesion device  1  in a use state. The adhesion device  1  in a use state illustrated in  FIGS. 8A and 8B  is in a side view seen from the same viewpoint as that of the side view of the adhesion device  1  in a pre-use state illustrated in  FIG. 3B .  FIG. 8A  illustrates a state of an inflator  55  as the compression member  22  to be described later before inflated.  FIG. 8B  illustrates a state of the inflator  55  as the compression member  22  after inflated. 
     As illustrated in  FIGS. 8A and 8B , the device main body  3  of the present embodiment includes a holder  21  and the compression member  22 . 
     «Holder  21 » 
     The holder  21  is fixed to the mounting surface  12  of the adhesion sheet  2 . In addition, the holder  21  holds the compression member  22 . 
     As illustrated in  FIG. 4B  and the like, in a plan view, the holder  21  of the present embodiment includes a portion that overlaps the adhesion sheet  2 , and a portion that does not overlap the adhesion sheet  2 . The portion of the holder  21  of the present embodiment, which overlaps the adhesion sheet  2 , is fixed to the mounting surface  12  of the adhesion sheet  2 . The portion of the holder  21  of the present embodiment, which does not overlap the adhesion sheet  2 , is located in the central opening region defined by the adhesion sheet  2  in a plan view. 
     Examples of the material of the holder  21  include a resin material. Examples of the resin material include thermoplastic resins used in injection molding, such as ABS resin, AS resin, polyethylene, polypropylene, polystyrene, polyvinyl chloride, polyvinylidene chloride resin, polyphenylene oxide, thermoplastic polyurethane, polymethylene methacrylate, polyoxyethylene, fluororesin, polycarbonate, polyamide, acetal resin, acrylic resin, and polyethylene terephthalate, thermosetting resins such as phenol resin, epoxy resin, silicone resin, and unsaturated polyester, and the like. 
     «Compression Member  22 » 
     The compression member  22  is held by the holder  21 . The compression member  22  is protrudable or configured to project toward the downward direction A 1 , which is the one side in the thickness direction A, from the adhesion surface  11  of the adhesion sheet  2 . In the adhesion device  1 , in a state where the adhesion surface  11  of the adhesion sheet  2  adheres to the biological surface, the compression member  22  protrudes or projects from the adhesion surface  11  of the adhesion sheet  2  to the downward direction A 1 . Accordingly, the biological surface is compressed by the compression member  22 . 
     The compression member  22  of the present embodiment is the inflator  55  that is inflatable toward the downward direction A 1  in the thickness direction A by supply of a fluid such as air. The form of the inflator  55  of the present embodiment is changed from a retracted form illustrated in  FIG. 8A  to a protruding form illustrated in  FIG. 8B , so that the inflator  55  protrudes from the adhesion surface  11  of the adhesion sheet  2  toward the downward direction A 1  in the thickness direction A to assume a posture, thus to be able to compress the biological surface. 
     Specifically, the adhesion device  1  of the present embodiment adheres to the biological surface when the adhesion device is in the retracted form (refer to  FIG. 8A ) before the inflator  55  as the compression member  22  is inflated. In a state where the adhesion device  1  is fixed to the biological surface, the inflator  55  is inflated by an operation of an operator such as a health care worker, to assume the protruding form (refer to  FIG. 8B ). Accordingly, in the adhesion device  1  of the present embodiment, the inflator  55  can compress a predetermined site on the biological surface. As described above, the predetermined site on the biological surface is a wound or the like formed by insertion of the medical insertion device into a blood vessel of the living body. After the above-described insertion device such as a sheath is extracted from the living body, the wound or the vicinity of the wound on the biological surface is compressed by the compression member  22  of the adhesion device  1 , so that hemostasis can be achieved. Details of a method of the series of compression will be described later (refer to  FIGS. 10A to 10H ). 
     As illustrated in  FIG. 8A , the inflator  55  as the compression member  22  of the present embodiment in the retracted form is substantially flush with the adhesion surface  11  of the adhesion sheet  2 , and does not protrude from or beyond the adhesion surface  11  to the downward direction A 1 . The holder  21  may include a lock mechanism which performs locking such that the inflator  55  in the retracted form does not protrude from or beyond the adhesion surface  11  of the adhesion sheet  2  to the downward direction A 1 . 
     The inflator  55  of the present embodiment defines an internal space  55   a . The internal space  55   a  of the inflator  55  communicates with a tube  61  that penetrates through the holder  21  to extend outside the holder  21 . For example, a fluid such as air is supplied through the tube  61  to the internal space  55   a  of the inflator  55  from a fluid supply device such as a syringe that is connected to an inflation port as a connection section  62  provided in an end portion of the tube  61 . Accordingly, the form of the inflator  55  can be changed from the retracted form (refer to  FIG. 8A ) to the protruding form (refer to  FIG. 8B ). Namely, the inflator  55  as the compression member  22  is protrudable to the downward direction A 1  from the adhesion surface  11  of the adhesion sheet  2 . The fluid to be supplied to the internal space of the inflator  55  is not limited to a gas, and may be a liquid. In addition, when the fluid is aspirated from the internal space  55   a  of the inflator  55 , the form of the inflator  55  can be changed from the protruding form (refer to  FIG. 8B ) to the retracted form (refer to  FIG. 8A ). 
     More specifically, as illustrated in  FIG. 8B , the compression member  22  of the present embodiment includes a contact portion  22   a  that comes into contact with the biological surface to directly compress the biological surface, and a pressing portion  22   b  that presses the contact portion  22   a  in a predetermined direction to increase the compression force of the contact portion  22   a  in the predetermined direction. Specifically, the inflator  55  as the compression member  22  of the present embodiment includes a first inflator  60   a  as the contact portion  22   a  and a second inflator  60   b  as the pressing portion  22   b.    
     The first inflator  60   a  defines a first internal space  60   a   1 . The second inflator  60   b  defines a second internal space  60   b   1 . The first internal space  60   a   1  and the second internal space  60   b   1  communicate with each other. In the retracted form of the inflator  55 , the first inflator  60   a  and the second inflator  60   b  in a deflated state overlap each other in the thickness direction A. The first inflator  60   a  in a deflated state is located on a lower side, and the second inflator  60   b  in a deflated state is located on an upper side to overlap the first inflator  60   a . The upward direction A 2  of the second inflator  60   b  is covered with the holder  21 . In addition, the first inflator  60   a  and the second inflator  60   b  are continuous with each other only at one end (left side in  FIG. 8B ) in a direction orthogonal to the thickness direction A. 
     The fluid which is supplied to the internal space  55   a  of the inflator  55  through the tube  61  flows into the second internal space  60   b   1  of the second inflator  60   b , and then flows into the first internal space  60   a   1  of the first inflator  60   a . For this reason, when the fluid is supplied to the internal space  55   a  of the inflator  55 , first, the second inflator  60   b  is inflated. As described above, since the upward direction A 2  of the second inflator  60   b  is covered with the holder  21 , the second inflator  60   b  to which the fluid has been supplied is inflated toward the downward direction A 1 . Next, the fluid flows into the first internal space  60   a   1 , and the first inflator  60   a  is inflated. At that time, the first inflator  60   a  is inflated to move rotationally around the one end (left side in  FIG. 8B ) in the direction orthogonal to the thickness direction A, the second inflator  60   b  being continuous with the first inflator  60   a  in the one end as a central axis of the rotary movement. Namely, when the fluid is supplied to the first internal space  60   a   1  of the first inflator  60   a , since the first inflator  60   a  is pressed by the second inflator  60   b , the first inflator  60   a  is inflated such that the other end (right side in  FIG. 8B ) with respect to the one end in the direction orthogonal to the thickness direction A moves to the downward direction A 1 , to assume the protruding form illustrated in  FIG. 8B . Accordingly, the compression force of the first inflator  60   a  in the predetermined direction (compression force in a lower left direction in  FIG. 8B ) can be increased. 
     As the inflator  55 , a balloon which is inflated by, for example, a gas such as air can be used. As the forming material of the inflator  55 , a material which is flexible such as soft polyvinyl chloride, polyurethane, polyethylene, polypropylene, polyester, ethylene-vinyl acetate copolymer (EVA), silicone, or a mixture of any of these materials can be used. 
     The configuration of the compression member  22  is not particularly limited. A compression member without the pressing portion  22   b  may be employed. In addition, even when the compression member  22  is formed of an inflator, the configuration is not limited to the above-described configuration of the inflator  55 . Further, the compression member  22  of the present embodiment is configured to protrude from the adhesion surface  11  of the adhesion sheet  2  to the downward direction A 1  by inflation, but may be a compression member that normally protrudes from the adhesion surface  11  of the adhesion sheet  2  to the downward direction A 1 . 
     In addition, as illustrated in  FIG. 8B , when the compression member  22  includes the pressing portion  22   b , it is preferable that the contact portion  22   a  of the compression member  22  is disposed to be biased toward a pressing direction (left side in  FIG. 8B ), in which the pressing portion  22   b  performs pressing, in the holder  21 . In other words, as illustrated in  FIG. 7 , it is preferable that the contact portion  22   a  of the compression member  22  is disposed to be biased toward a receiving portion  14  side of the adhesion sheet  2  from the center position of the holder  21  in the holder  21  in a plan view. 
     &lt;&lt;&lt;Cover Portion  23  of Holder  21 &gt;&gt;&gt; 
     Next, the holder  21  of the present embodiment will be described in further detail. The holder  21  of the embodiment includes a cover portion  23  and a support portion  24 . 
     The cover portion  23  covers the upward direction A 2  of the inflator  55  as the compression member  22 . In addition, the cover portion  23  is mounted to the inflator  55  as the compression member  22 . 
     As illustrated in  FIG. 4B  and the like, in a plan view, the cover portion  23  of the present embodiment is located in the central opening region defined by the adhesion sheet  2 . In other words, the cover portion  23  of the present embodiment is a portion of the holder  21 , which does not overlap the adhesion sheet  2  in a plan view. 
     As illustrated in  FIG. 1 , the cover portion  23  of the present embodiment includes two plate portions  23   a  that protrude upward. The two plate portions  23   a  are disposed to face each other, and form a grip portion of the device main body  3 . In the present embodiment, the two plate portions  23   a  form the grip portion; however, the grip portion is not limited to the configuration. The grip portion may be formed of one plate portion  23   a.    
     &lt;&lt;&lt;Support Portion  24  of Holder  21 &gt;&gt;&gt; 
     The support portion  24  supports the cover portion  23 , and is fixed to the mounting surface  12  of the adhesion sheet  2 . In addition, a part of the support portion  24  of the present embodiment is continuous with the cover portion  23 , and the support portion  24  supports the cover portion  23  in the continuous place. 
     As illustrated in  FIG. 4B  and the like, in a plan view, a part of the support portion  24  of the present embodiment is disposed at a position where the part overlaps the adhesion sheet  2 . In other words, a part of the support portion  24  of the present embodiment is a portion of the holder  21 , which overlaps the adhesion sheet  2  in a plan view. Specifically, the support portion  24  of the present embodiment includes a portion that extends along the adhesion sheet  2  having a C shape in a plan view, and a lower surface of the portion is fixed to the mounting surface  12  of the adhesion sheet  2 . In addition, in a plan view, the support portion  24  of the present embodiment extends to surround (e.g., completely surround) the cover portion  23 . As illustrated in  FIG. 7 , the support portion  24  may be annular and configured to completely surround or encircle a central open area at which is located the compression member  22 . 
     The support portion  24  of the present embodiment is fixed to the mounting surface  12 , for example, by bonding, fusion, or the like; however, as long as a portion of the adhesion sheet  2  is located in the upward direction A 2  above the adhesion surface  11 , the position of the portion, at which the support portion  24  is fixed, is not particularly limited. Therefore, the support portion  24  may be fixed to a layer located in the downward direction A 1  below the mounting surface  12 . With the configuration where the support portion  24  of the device main body  3  is fixed to the mounting surface  12  of the adhesion sheet  2  by bonding, fusion, or the like, the device main body  3  can be easily mounted to the adhesion sheet  2 . 
     &lt;Release Sheet  4 &gt; 
     As described above, the release sheet  4  includes the release layer  4   a  and the folded layer  4   b . In addition, the folded layer  4   b  of the release sheet  4  is layered on the release layer  4   a  at the position of the second portion X 2  of the adhesion sheet  2 . 
     The release sheet  4  of the present embodiment has two folds  30 , which are linear, at an outer edge of the release layer  4   a . In addition, the release sheet  4  of the present embodiment includes a fold  31  between the folded layers  4   b  in addition to the folds  30 . Hereinafter, for convenience of description, a fold of the two folds  30  which is far from the fold  31  between the folded layers  4   b  is referred to as a “first fold  30   a ”. In addition, a fold of the two folds  30  which is close to the fold  31  between the folded layers  4   b  is referred to as a “second fold  30   b”.    
     As illustrated in  FIG. 7  and the like, in a plan view, the first fold  30   a  which is one of the two folds (fold lines or fold edges)  30  between the release layer  4   a  and the folded layer  4   b  of the release sheet  4  passes through the first portion X 1  of the adhesion sheet  2  in a plan view. In other words, in a plan view, at least a part of the first fold  30   a  overlaps the first portion X 1  of the adhesion sheet  2 . The folded layer  4   b  is moved to cause the release layer  4   a  of the release sheet  4  to be released from the adhesion surface  11  of the adhesion sheet  2 . For this reason, the release layer  4   a  is released from the position of the fold  30  with respect to the adhesion surface  11  of the adhesion sheet  2 . With the configuration where the first fold  30   a  passes through the first portion X 1  of the adhesion sheet  2  in a plan view, the position of the first portion X 1  of the adhesion sheet  2  can be set as the release start position of the release layer  4   a  of the release sheet  4 . Since the release layer  4   a  of the release sheet  4  starts being released from the first portion X 1  of the adhesion sheet  2 , as compared to when release starts from the second portion X 2  of the adhesion sheet  2 , the release sheet  4  is more easily released from the adhesion sheet  2 . Namely, the winding and bending of the second portion X 2  of the adhesion sheet  2  caused by the release operation of the release sheet  4  can be suppressed. 
     As illustrated in  FIG. 7  and the like, the first fold  30   a  of the present embodiment passes through the first portion X 1  of the adhesion sheet  2  in a plan view, but may be a fold that does not pass through the first portion X 1  and the second portion X 2  of the adhesion sheet  2  in a plan view. Even with such a fold, when the second portion X 2  does not intervene between the fold and the first portion X 1  of the adhesion sheet  2  in a plan view, the same effect as described above can be obtained. Further, even when the second portion X 2  intervenes between the fold and the first portion X 1  of the adhesion sheet  2  in a plan view but the length of the second portion X 2  is sufficiently short (for example, 2 mm or less), the same effect as described above can be obtained. 
     As illustrated in  FIG. 7  and the like, in a plan view, the second fold  30   b  which is the other of the two folds  30  between the release layer  4   a  and the folded layer  4   b  of the release sheet  4  does not pass through the first portion X 1  of the adhesion sheet  2  in a plan view. However, in a plan view, the second fold  30   b  does not pass through the first portion X 1  and the second portion X 2  of the adhesion sheet  2 . In addition, in a plan view, the second portion X 2  intervenes between the second fold  30   b  and the first portion X 1  of the adhesion sheet  2 , but the length of the second portion X 2  is sufficiently short (2 mm or less). Therefore, the same effect as that in the first fold  30   a  described above can be obtained even at the position of the second fold  30   b.    
     Here, as illustrated in  FIG. 6  and the like, in a plan view, the device main body  3  is interposed between a portion of the first fold  30   a , which overlaps the first portion X 1  of the adhesion sheet  2 , and the extending portion  50  as the designated grip portion of the sheet grip portion which is formed of the folded layer  4   b . With such a configuration, the release sheet  4  is easily released while passing through the first portion X 1  of the adhesion sheet  2  on a lower surface of the device main body  3 . Namely, the possibility that the release sheet  4  is released only from the position of the second portion X 2  of the adhesion sheet  2  can be reduced. In other words, when the release sheet  4  is released from a predetermined place on the second portion X 2  of the adhesion sheet  2 , the possibility that the release sheet  4  is released from a predetermined place on the first portion X 1  of the adhesion sheet  2  can be increased. For this reason, the winding and bending of the second portion X 2  of the adhesion sheet  2  caused by the release operation of the release sheet  4  can be suppressed. 
     Further, as illustrated in  FIG. 7  and the like, in a plan view, the holder  21  of the device main body  3 , more specifically, the support portion  24  of the holder  21  is interposed between the portion of the first fold  30   a , which overlaps the first portion X 1  of the adhesion sheet  2 , and the extending portion  50  as the designated grip portion of the sheet grip portion which is formed of the folded layer  4   b . As described above, in a plan view, the support portion  24  of the present embodiment extends to surround the cover portion  23 . In addition, in a plan view, a part of the support portion  24  (for example, refer to the position of reference sign “ 24   a ” in  FIG. 7 ) of the present embodiment extends from the portion of the first fold  30   a , which overlaps the first portion X 1  of the adhesion sheet  2 , in a direction toward the extending portion  50  as the designated grip portion of the sheet grip portion. As a consequence, when the extending portion  50  as the designated grip portion is moved to the outside of the device main body  3  in a plan view, the release sheet  4  can be released along the first portion X 1  of the adhesion sheet  2  which is located below the support portion  24 . For this reason, the winding and bending of the second portion X 2  of the adhesion sheet  2  caused by the release operation of the release sheet  4  can be further suppressed. 
     In addition, as illustrated in  FIG. 7  and the like, in the present embodiment, in a plan view, the extending portion  50  as the designated grip portion of the sheet grip portion is formed at a position different from that of the receiving portion  14  defined by the adhesion sheet  2 . As a consequence, in a state where a portion of the insertion device such as a sheath which is inserted into the living body remains received by the receiving portion  14 , the portion extending outside the living body, the extending portion  50  as the designated grip portion of the sheet grip portion can be operated to release the release sheet  4  from the adhesion sheet  2 . 
     Further, as illustrated in  FIG. 7  and the like, in a plan view, the release sheet  4  of the present embodiment is not provided in at least a part of the receiving portion  14  defined by the adhesion sheet  2 . Namely, even in a pre-use state before the release sheet  4  is released, the receiving portion  14  defined by the adhesion sheet  2  can receive the insertion device such as a sheath from the outside. 
     As the release sheet  4 , a plastic film made of, for example, polyethylene, polyvinyl chloride, polyester, polypropylene, or the like, paper, a metal film, a cloth, or the like can be used. In addition, the release sheet  4  may be a single-layer film which is formed of a film of one layer, or may be a laminated film in which a plurality of types of films are laminated. Further, a release treatment such as a silicon treatment or embossing may be applied to the surface of the release sheet  4 , to which the adhesion surface  11  of the adhesion sheet  2  adheres. The thickness of the release sheet  4  is, for example, from 15 μm to 200 μm, preferably, 40 μm to 100 μm. 
     In the present embodiment, the tensile modulus of the release sheet  4  is smaller than the tensile modulus of the adhesion sheet  2 . Namely, both the adhesion sheet  2  and the release sheet  4  are flexible, and in the present embodiment, the adhesion sheet  2  has a higher flexibility and is more easily bent than the release sheet  4 . For this reason, when the release sheet  4  is operated to be released from the second portion X 2  of the adhesion sheet  2 , the second portion X 2  of the adhesion sheet  2  is easily bent and deformed according to the release sheet  4 . The tensile modulus of the release sheet  4  may be the same as the tensile modulus of the adhesion sheet  2  or may be more than the tensile modulus of the adhesion sheet  2 . 
     &lt;Compression Method Performed Using Adhesion Device  1 &gt; 
     Next, a method of compressing a biological surface (e.g., surface of a patient&#39;s body), which is performed using the adhesion device  1 , will be described.  FIG. 9  is a flowchart illustrating one example of the method of compressing a biological surface. The compression method illustrated in  FIG. 9  includes a mounting step S 1 , a first compression step S 2 , an extraction step S 3 , and a second compression step S 4 .  FIGS. 10A to 10E  are views illustrating an outline of the mounting step S 1 .  FIG. 10F  is a view illustrating an outline of the first compression step S 2 .  FIG. 10G  is a view illustrating an outline of the extraction step S 3 .  FIG. 10H  is a view illustrating an outline of the second compression step S 4 . 
     The compression method illustrated in  FIGS. 9 and 10A to 10H  is a compression method by which the biological surface BS is compressed to narrow or obstruct a perforation, which is formed or results upon extraction of a sheath as an insertion device  100  in the state of being inserted into, for example, a vein such as a femoral vein from the biological surface BS through a connective tissue, without obstructing the vein. Accordingly, hemostasis can be performed after the sheath as the insertion device  100  is extracted. First, the perforation which is formed after the insertion device  100  is extracted will be described with reference to  FIGS. 32A and 32B .  FIG. 32A  illustrates a state where the sheath as the insertion device  100  is inserted into a femoral vein FV from the biological surface BS through a connective tissue CT.  FIG. 32A  illustrates three sheaths as the insertion device  100 ; however, the number of the sheaths may be two or less or may be four or more.  FIG. 32B  illustrates a state of the sheath as the insertion device  100  after extracted from the state illustrated in  FIG. 32A . As illustrated in  FIG. 32B , when the sheaths as the insertion device  100  are extracted, perforations P are formed between the biological surface BS and the femoral vein FV. In the compression method illustrated in  FIGS. 9 and 10A to 10H , the perforations P can be narrowed or obstructed without obstructing the femoral vein FV. Hereinafter, steps S 1  to S 4  will be described in detail with reference to  FIGS. 10A to 10H . 
       FIG. 10A  illustrates a state where the sheath as the insertion device  100  is inserted into the femoral vein FV from the biological surface BS (refer to  FIGS. 32A and 32B ). First, in this state, the adhesion device  1  is mounted on the biological surface BS. 
     As illustrated in  FIG. 9 , the mounting step S 1  includes an alignment step S 1 - 1  of aligning the mounting position of the adhesion device  1  on the biological surface BS, a release sheet removing step S 1 - 2  of releasing the release sheet  4  from the adhesion surface  11  of the adhesion sheet  2 , and an adhesion step S 1 - 3  of causing the adhesion surface  11  of the adhesion sheet  2  to adhere to the biological surface BS. 
       FIGS. 10A and 10B  are views illustrating an outline of the alignment step S 1 - 1  of the mounting step S 1 . As illustrated in  FIG. 10B , in the alignment step S 1 - 1 , the adhesion position of the adhesion device  1  is aligned such that a portion of the sheath as the insertion device  100  is received by the receiving portion  14 , the portion extending outside the living body. 
       FIGS. 10C and 10D  are views illustrating an outline of the release sheet removing step S 1 - 2  of the mounting step S 1 . As illustrated in  FIGS. 10C and 10D , in the release sheet removing step S 1 - 2 , an operator such as a health care worker releases the release sheet  4  from the adhesion sheet  2  while holding the adhesion device  1  in a place where the alignment is made in the alignment step S 1 - 1 . As illustrated in  FIGS. 10C and 10D , in a state where the device main body  3  remains held with one hand of the operator, the release sheet  4  is released with the other hand of the operator. As a consequence, the adhesion device  1  is easily held in the place where the alignment is made in the alignment step S 1 - 1 . For this reason, it is preferable that the device main body  3  is provided with a grip portion which is easy for the operator to grip. As described above, in the present embodiment, the grip portion is formed of the two plate portions  23   a  provided in the cover portion  23  of the holder  21  of the device main body  3 . 
       FIG. 10E  is a view illustrating an outline of the adhesion step S 1 - 3  of the mounting step S 1 . As illustrated in  FIG. 10E , in the adhesion step S 1 - 3 , the adhesion surface  11  of the adhesion sheet  2 , which is exposed in the release sheet removing step S 1 - 2 , adheres to the biological surface BS. The place where adhesion is performed in the adhesion step S 1 - 3  is a place on the biological surface BS, in which the alignment is made in the alignment step S 1 - 1 . In such a manner, the adhesion device  1  can be mounted in a predetermined place on the biological surface BS. 
     Next, as illustrated in  FIG. 10F , a syringe  70  as a fluid supply device is connected to the connection section  62  of the tube  61 . Air is supplied to the inflator  55  (refer to  FIG. 8B ) as the compression member  22  of the adhesion device  1  through the tube  61  to inflate the inflator  55 . As a consequence, before the sheath as the insertion device  100  is extracted from the biological surface BS, the vicinity of a wound on the biological surface BS can be compressed in advance. In other words, the compression of the biological surface BS starts in a state where the sheath as the insertion device  100  is inserted into or remains positioned in the femoral vein FV as a vein from the biological surface BS through the connective tissue CT (refer to  FIGS. 32A and 32B ). As described above, since compression is performed before the insertion device  100  is extracted from the biological surface BS, immediately after the sheath as the insertion device  100  is extracted, the biological surface BS can be compressed such that the perforations P (refer to  FIG. 32B ) extending from the biological surface BS to the femoral vein FV (refer to  FIGS. 32A and 32B ) are narrowed or obstructed. 
     Next, as illustrated in  FIG. 10G , the sheath as the insertion device  100  is extracted from the biological surface BS. More specifically, the sheath as the insertion device  100  of the present embodiment is extracted from the living body through the receiving portion  14  of the adhesion sheet  2 . The perforations P illustrated in  FIG. 32B  are formed by extraction of the sheath. If the biological surface BS is not compressed at all in this state, bleeding occurs from the femoral vein FV to the outside of the living body through the perforations P and the wound on the biological surface BS. However, in the compression method illustrated here, as illustrated in  FIG. 10F , before the sheath as the insertion device  100  is extracted from the biological surface BS, the biological surface BS is compressed in advance. For this reason, immediately after the sheath is extracted, the biological surface BS can be compressed such that the perforations P (refer to  FIG. 32B ) are narrowed or obstructed, and the amount of bleeding immediately after extraction of the sheath can be suppressed. 
     Next, as illustrated in  FIG. 10H , the syringe  70  as a fluid supply device is connected again to the connection section  62  of the tube  61 . Air is supplied again to the inflator  55  (refer to  FIG. 8B ) as the compression member  22  of the adhesion device  1  through the tube  61  to apply pressure, or is removed to reduce pressure. In other words, the compression force of the biological surface BS after extraction of the sheath as the insertion device  100  is adjusted. Accordingly, the compression force of the biological surface BS is adjusted to further narrow or obstruct the perforations P (refer to  FIG. 32B ) without obstructing the femoral vein FV (refer to  FIGS. 32A and 32B ), so that the amount of bleeding can be greatly reduced or bleeding can be stopped. 
     More specifically, when bleeding is confirmed after the sheath is extracted, the compression force is slowly increased to apply pressure until hemostasis is achieved. On the other hand, when hemostasis is confirmed after the sheath is extracted, the compression force is slowly decreased to reduce pressure until bleeding is confirmed. Then, after bleeding is confirmed, the compression force is slowly increased to apply pressure until hemostasis is achieved. As a consequence, the obstruction of the femoral vein FV (refer to  FIGS. 32A and 32B ) by overpressurization can be prevented. 
     The compression state is maintained for several hours (for example, two to six hours) as it is, so that hemostasis can be completed. After hemostasis is completed, the adhesion surface  11  of the adhesion sheet  2  is released from the biological surface BS, so that the adhesion device  1  is removed from the biological surface BS. 
     In the compression method illustrated here, the perforations P (refer to  FIG. 32B ) are narrowed or obstructed without obstructing the femoral vein FV (refer to  FIGS. 32A  and  32 B). In the case of hemostasis of a vein, hemostasis can be performed by narrowing or obstructing the perforations P (refer to  FIG. 32B ). For example, in the case of hemostasis of a femoral artery, even when only perforations are obstructed, blood leaks and spreads in the connective tissue CT (refer to  FIGS. 32A and 32B ), so that hemostasis cannot be achieved. In the case of hemostasis of the femoral artery, a large-scale measure such as a method of applying strong compression to the extent that the artery itself is narrowed or obstructed or a method of closing a hole in an artery wall is required. 
     Therefore, in the above-described compression method, it is preferable that the biological surface BS is compressed to a position where the compression depth from the biological surface BS is from 5 mm to 20 mm. When the compression depth is set in the above range, a compression state where the perforations P (refer to  FIG. 32B ) are narrowed or obstructed without obstructing the vein is easily realized. The compression depth is more preferably set in a range of 5 mm to 15 mm, further preferably, in a range of 8 mm to 12 mm. Further, as illustrated in  FIG. 8B , in the present embodiment, the inflator  55  as the compression member  22  includes the second inflator  60   b  as the pressing portion  22   b . For this reason, according to the compression member  22  of the present embodiment, the compression force in a direction orthogonal to an extending direction of the perforations P (refer to  FIG. 32B ) can be increased. Accordingly, the compression state where the perforations P (refer to  FIG. 32B ) are narrowed or obstructed without obstructing the vein is more easily realized. 
     Further, in the above-described compression method, it is preferable that the biological surface BS is compressed at 25 g/cm 2  to 400 g/cm 2 . The compression pressure is a pressure after the sheath as the insertion device  100  is extracted, and does not mean the above-described compression force before extraction of the sheath. When the compression pressure is set in the above range, the compression state where the perforations P (refer to  FIG. 32B ) are narrowed or obstructed without obstructing the vein is easily realized. The compression pressure is more preferably set in a range of 50 g/cm 2  to 400 g/cm 2 , further preferably, in a range of 100 g/cm 2  to 300 g/cm 2 . 
     According to the compression method illustrated in  FIGS. 9 and 10A to 10H , hemostasis can be performed by narrowing or obstructing the perforations P (refer to  FIG. 32B ) without obstructing the vein such as the femoral vein FV. Particularly, the above-described compression method is realized by the adhesion device  1 , so that compression by the hand of a health care worker, the use of a large-scale hemostat device, or the like is not required, and hemostasis can be performed by a simple method. Further, as illustrated in  FIG. 32B , even when a plurality of the perforations P are collectively formed, the plurality of perforations P can be collectively narrowed or obstructed. 
     Second Embodiment 
     Next, an adhesion device  101  in a second embodiment will be described with reference to  FIGS. 11 to 15 .  FIG. 11  is a top view of the adhesion device  101  in the present embodiment.  FIG. 12  is a bottom view of the adhesion device  101 .  FIGS. 13A and 13B  are side views of the adhesion device  101 .  FIGS. 13A and 13B  are side views seen from different viewpoints.  FIG. 14  is a view illustrating a release sheet  104  of the adhesion device  101 .  FIG. 14  illustrates a method of forming the release sheet  104 .  FIG. 15  is a perspective view of the release sheet  104  of the adhesion device  101 . 
     The adhesion device  101  includes the adhesion sheet  2 , the device main body  3 , and the release sheet  104 . Since the adhesion sheet  2  and the device main body  3  of the adhesion device  101  are the same as those of the adhesion device  1  of the first embodiment, the description thereof will not be repeated. In addition, the release sheet  104  is different in folding method from the release sheet  4  (refer to  FIG. 1  and the like) of the first embodiment, and other configurations are the same. Therefore, in the description below, the points of difference of the release sheet  104  of the present embodiment over the release sheet  4  described above will be mainly described, and the description of other common previously described will not be repeated. 
     As illustrated in  FIGS. 14 and 15 , the release sheet  104  includes a release layer  104   a  and a folded layer  104   b . The configuration of the release layer  104   a  of the release sheet  104  is the same as that of the release layer  4   a  of the release sheet  4  described above. The folded layer  104   b  of the release sheet  104  is different from the folded layer  4   b  of the release sheet  4  described above. As illustrated in  FIG. 15 , a part of the folded layer  104   b  of the release sheet  104  may include three layers that are folded in a zigzag shape. 
     Third Embodiment 
     Next, an adhesion device  201  in a third embodiment will be described with reference to  FIGS. 16 to 20 .  FIG. 16  is a perspective view of the adhesion device  201 .  FIG. 17  is an exploded perspective view of the adhesion device  201 .  FIG. 18  is a top view of the adhesion device  201 .  FIG. 19  is a bottom view of the adhesion device  201 .  FIG. 20  is a view illustrating a release sheet  204  of the adhesion device  201 .  FIG. 20  illustrates a method of forming the release sheet  204 . 
     The adhesion device  201  includes the adhesion sheet  2 , the device main body  3 , and the release sheet  204 . Since the adhesion sheet  2  and the device main body  3  of the adhesion device  201  are the same as those of the adhesion device  1  of the first embodiment, the description thereof will not be repeated. 
     The release sheet  204  releasably adheres to the adhesion surface  11  of the adhesion sheet  2 . When the adhesion device  201  is to be adhered to the biological surface, the release sheet  204  is released from the adhesion surface  11 . Accordingly, the adhesion surface  11  of the adhesion sheet  2  is exposed to the outside, and the adhesion device  201  is in the state of being able to adhere to the biological surface. 
     As illustrated in  FIGS. 16 to 20 , the release sheet  204  includes a release layer  204   a  that adheres to the adhesion surface  11  of the adhesion sheet  2 , and a folded layer  204   b  which is formed of at least one layer (one layer in the present embodiment) and is folded to a side, which is opposite to the adhesion surface  11  with respect to the release layer  204   a , to be layered. 
     As illustrated in  FIG. 16 , the folded layer  204   b  of the release sheet  204  is layered on the release layer  204   a  of the release sheet  204  at least at the position of the second portion X 2  of the adhesion sheet  2 . Since the release sheet  204  has such a configuration, similar to the release sheet  4  of the first embodiment, the release sheet  204  is easily released from the second portion X 2  of the adhesion sheet  2  (refer to  FIG. 18  and the like). 
     As illustrated in  FIG. 17  and the like, in the present embodiment, the entire region of the adhesion surface  11  of the adhesion sheet  2  is covered with two release sheets  204  which are symmetrical in shape.  FIG. 20  illustrates only one release sheet  204  of the two release sheets  204  which are symmetrical in shape. Since the two release sheets  204  are symmetrical in shape, hereinafter, only the one release sheet  204  will be described as an example. As illustrated in  FIG. 20 , the release sheet  204  of the present embodiment is folded once from an original form of a single layer (left figure in  FIG. 20 ) to be shaped into a completed form of two layers (right figure in  FIG. 20 ). In such a manner, the release sheet  204  including the release layer  204   a  which is formed of one layer and the folded layer  204   b  which is formed of one layer is formed. 
     As illustrated in  FIG. 20 , the original form (left figure in  FIG. 20 ) of a single layer in the release sheet  204  of the present embodiment has a substantially C-shaped or a substantially U-shaped outer shape in a plan view seen in the thickness direction. In other words, the original form (left figure in  FIG. 20 ) of the release sheet  204  of the present embodiment is not formed in an endless shape in a plan view seen in the thickness direction, and a gap is provided in a part of the original form. In addition, the release sheet  204  of the present embodiment is folded such that a fold (fold line or fold edge)  230  in the completed form (right figure in  FIG. 20 ) is formed in one place. In other words, a virtual straight line obtained by extending only one fold  230  which is linear passes through the above-described gap of the release sheet  204  in the original form (left figure in  FIG. 20 ) unfolded from the completed form (right figure in  FIG. 20 ). 
     As described above, the release sheet  204  of the present embodiment has only one fold  230  between the release layer  204   a  and the folded layer  204   b . In addition, the fold  230  is disposed to be located toward one end when the release sheet  204  is in the completed form (right figure in  FIG. 20 ). That is, the fold  230  may be at one end of the release sheet  240  when the release sheet  204  is in the completed form. For this reason, a latch section which latches one of the release layer  204   a  and the folded layer  204   b  to the other is provided at the position of the other end, which is opposite to the one end where the fold  230  is provided, when the release sheet  204  is in the completed form (right figure in  FIG. 20 ). Accordingly, the other end which is far from the fold  230  of the folded layer  204   b  can be suppressed from hanging down from the release layer  204   a . The latch section of the present embodiment is formed of a projection portion  204   a   1  of the release layer  204   a , and a slit  204   b   1  of the folded layer  204   b . The projection portion  204   a   1  is formed in a part of an outer edge of the release layer  204   a . The projection portion  204   a   1  can be inserted into the slit  204   b   1  when the release sheet  204  is in the completed form (right figure in  FIG. 20 ). The latch section is not limited to the above-described configuration illustrated in the present embodiment. For example, the projection portion may be provided in the folded layer, and the slit may be provided in the release layer. It is preferable that since a latch state can be easily released, the latch section formed of the projection portion and the slit described above is employed. 
     As illustrated in  FIG. 19  and the like, in a plan view, the fold  230  between the release layer  204   a  and the folded layer  204   b  of the release sheet  204  passes through the first portion X 1  of the adhesion sheet  2 . As a consequence, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the position of the first portion X 1  of the adhesion sheet  2  can be set as a release start position of the release layer  204   a  of the release sheet  204 . Accordingly, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the winding and bending of the second portion X 2  of the adhesion sheet  2  caused by the release operation of the release sheet  204  can be suppressed. 
     Here, as illustrated in  FIG. 18  and the like, in a plan view, the device main body  3  is interposed between a portion of the fold  230 , which overlaps the first portion X 1  of the adhesion sheet  2 , and an extending portion  250  as a designated grip portion of a sheet grip portion which is formed of the folded layer  204   b . With such a configuration, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the release sheet  204  is easily released while passing through the first portion X 1  of the adhesion sheet  2  on the lower surface of the device main body  3 . Namely, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the winding and bending of the second portion X 2  of the adhesion sheet  2  caused by the release operation of the release sheet  204  can be suppressed. 
     Further, as illustrated in  FIG. 18  and the like, in a plan view, the holder  21  of the device main body  3 , more specifically, the support portion  24  of the holder  21  is interposed between the portion of the fold  230 , which overlaps the first portion X 1  of the adhesion sheet  2 , and the extending portion  250  as the designated grip portion of the sheet grip portion which is formed of the folded layer  204   b . As illustrated in  FIG. 19  and the like, in a plan view, the support portion  24  of the present embodiment extends to surround the cover portion  23 . In addition, in a plan view, a part of the support portion  24  (for example, refer to the position of reference sign “ 24   a ” in  FIG. 19 ) of the present embodiment extends from the portion of the fold  230 , which overlaps the first portion X 1  of the adhesion sheet  2 , in a direction toward the extending portion  250  as the designated grip portion of the sheet grip portion. As a consequence, when the extending portion  250  as the designated grip portion is moved to the outside of the device main body  3  in a plan view, the release sheet  204  can be released along the first portion X 1  of the adhesion sheet  2  which is located below the support portion  24 . For this reason, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the winding and bending of the second portion X 2  of the adhesion sheet  2  caused by the release operation of the release sheet  204  can be further suppressed. 
     In addition, as illustrated in  FIG. 18  and the like, in the present embodiment, in a plan view, the extending portion  250  as the designated grip portion of the sheet grip portion is formed at a position different from that of the receiving portion  14  defined by the adhesion sheet  2 . As a consequence, in a state where a portion of the insertion device such as a sheath which is inserted into the living body remains received by the receiving portion  14 , the portion extending outside the living body, the extending portion  250  as the designated grip portion of the sheet grip portion can be operated to release the release sheet  204  from the adhesion sheet  2 . 
     A mark which guides an operator such as a health care worker through a predetermined operation may be formed in the extending portion  250  as the designated grip portion of the sheet grip portion. Examples of such a mark include various marks which guide that the extending portion  250  is to be gripped to release the release sheet  204 , various marks such as arrows which guide or direct a direction in which the extending portion  250  is moved when the release sheet  204  is released, and the like. 
     Further, as illustrated in  FIG. 18  and the like, in a plan view, the release sheet  204  of the present embodiment is not provided in at least a part of the receiving portion  14  defined by the adhesion sheet  2 . Namely, even in a pre-use state before the release sheet  204  is released, the receiving portion  14  defined by the adhesion sheet  2  can receive the insertion device  100  such as a sheath (refer to  FIG. 10A  and the like) from the outside. 
     Fourth Embodiment 
     Next, an adhesion device  301  in a fourth embodiment will be described with reference to  FIGS. 21 to 25 .  FIG. 21  is a perspective view of the adhesion device  301 .  FIG. 22  is an exploded perspective view of the adhesion device  301 .  FIG. 23  is a top view of the adhesion device  301 .  FIG. 24  is a bottom view of the adhesion device  301 .  FIG. 25  is a view illustrating a release sheet  304  of the adhesion device  301 .  FIG. 25  illustrates a method of forming the release sheet  304 . 
     The adhesion device  301  includes the adhesion sheet  2 , the device main body  3 , and the release sheet  304 . Since the adhesion sheet  2  and the device main body  3  of the adhesion device  301  are the same as those of the adhesion device  1  of the first embodiment, the description thereof will not be repeated. 
     The release sheet  304  releasably adheres to the adhesion surface  11  of the adhesion sheet  2 . When the adhesion device  301  adheres to the biological surface, the release sheet  304  is released from the adhesion surface  11 . Accordingly, the adhesion surface  11  of the adhesion sheet  2  is exposed to the outside, and the adhesion device  301  is in the state of being able to adhere to the biological surface. 
     As illustrated in  FIGS. 21 to 25 , the release sheet  304  includes a release layer  304   a  that adheres to the adhesion surface  11  of the adhesion sheet  2 , and a folded layer  304   b  which is formed of at least one layer (one layer in the present embodiment) and is folded to a side, which is opposite to the adhesion surface  11  with respect to the release layer  304   a , to be layered. 
     As illustrated in  FIG. 21 , the folded layer  304   b  of the release sheet  304  is layered on the release layer  304   a  of the release sheet  304  at least at the position of the second portion X 2  of the adhesion sheet  2 . Since the release sheet  304  has such a configuration, similar to the release sheet  4  of the first embodiment, the release sheet  304  is easily released from the second portion X 2  of the adhesion sheet  2  (refer to  FIG. 23  and the like). 
     As illustrated in  FIG. 22  and the like, in the present embodiment, the entire region of the adhesion surface  11  of the adhesion sheet  2  is covered with two sets of pairs of release sheet groups  380   a  and  380   b  which are symmetrical in shape.  FIG. 25  illustrates only one release sheet group  380   a  of the two sets of release sheet groups  380   a  and  380   b  which are symmetrical in shape. Since the two sets of release sheet groups  380   a  and  380   b  are symmetrical in shape, hereinafter, only one release sheet group  380   a  will be described as an example. 
     The release sheet group  380   a  includes two release sheets  304 . As illustrated in  FIG. 25 , each of the two release sheets  304  of the present embodiment is folded once from an original form of a single layer (left figure in  FIG. 25 ) to be shaped into a completed form of two layers (middle figure in  FIG. 25 ). In such a manner, each of the two release sheets  304  including the release layer  304   a  which is formed of one layer and the folded layer  304   b  which is formed of one layer is formed. 
     Next, parts of the two release sheets  304  overlap each other in the thickness direction, so that the release sheet group  380   a  (right figure in  FIG. 25 ) is formed. Specifically, in the present embodiment, the release layers  304   a  of the two release sheets  304  do not overlap each other in the thickness direction. The folded layer  304   b  of one release sheet  304  overlaps the release layer  304   a  and the folded layer  304   b  of the other release sheet  304  in the thickness direction. In addition, the folded layer  304   b  of the other release sheet  304  overlaps the release layer  304   a  and the folded layer  304   b  of the one release sheet  304  in the thickness direction. In such a manner, the release sheet group  380   a  (right figure in  FIG. 25 ) is formed. 
     As illustrated in  FIG. 25 , each of the release sheets  304  of the release sheet group  380   a  of the present embodiment has only one fold  330  between the release layer  304   a  and the folded layer  304   b.    
     As illustrated in  FIG. 24  and the like, in a plan view, the fold (fold line or fold edge)  330  between the release layer  304   a  and the folded layer  304   b  of the one release sheet  304  (the release sheet  304  on the upper side in  FIG. 25 ) of the release sheet group  380   a  passes through the first portion X 1  of the adhesion sheet  2 . As a consequence, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the position of the first portion X 1  of the adhesion sheet  2  can be set as a release start position of the release layer  304   a  of the one release sheet  304  (the release sheet  304  on the upper side in  FIG. 25 ) of the release sheet group  380   a . Accordingly, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the winding and bending of the second portion X 2  of the adhesion sheet  2  caused by the release operation of the release sheet  304  can be suppressed. 
     Here, in the one release sheet  304  (the release sheet  304  on the upper side in  FIG. 25 ) of the release sheet group  380   a , attention is paid to the folded layer  304   b  and the fold  330 . As illustrated in  FIG. 23  and the like, in a plan view, the device main body  3  is interposed between a portion of the fold  330 , which overlaps the first portion X 1  of the adhesion sheet  2 , and an extending portion  350  as a designated grip portion of a sheet grip portion which is formed of the folded layer  304   b . With such a configuration, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the one release sheet  304  (the release sheet  304  on the upper side in  FIG. 25 ) of the release sheet group  380   a  is easily released while passing through the first portion X 1  of the adhesion sheet  2  on the lower surface of the device main body  3 . Namely, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the winding and bending of the second portion X 2  of the adhesion sheet  2  caused by the release operation of the one release sheet  304  (the release sheet  304  on the upper side in  FIG. 25 ) of the release sheet group  380   a  can be suppressed. 
     On the other hand, as illustrated in  FIG. 24  and the like, in a plan view, the fold  330  between the release layer  304   a  and the folded layer  304   b  of the other release sheet  304  (the release sheet  304  on the lower side in  FIG. 25 ) of the release sheet group  380   a  does not pass through the first portion X 1  of the adhesion sheet  2 . However, in a plan view, the fold  330  of the other release sheet  304  (the release sheet  304  on the lower side in  FIG. 25 ) does not pass through both the first portion X 1  and the second portion X 2  of the adhesion sheet  2 . In addition, in a plan view, the second portion X 2  intervenes between the fold  330  and the first portion X 1  of the adhesion sheet  2 , but the length of the second portion X 2  is sufficiently short (2 mm or less). Therefore, the same effect as that in the fold  330  of the one release sheet  304  (the release sheet  304  on the upper side in  FIG. 25 ) can be obtained even at the position of the fold  330  of the other release sheet  304  (the release sheet  304  on the lower side in  FIG. 25 ) of the release sheet group  380   a.    
     Here, in the other release sheet  304  (the release sheet  304  on the lower side in  FIG. 25 ) of the release sheet group  380   a , attention is paid to the folded layer  304   b  and the fold  330 . As illustrated in  FIG. 23  and the like, in a plan view, the device main body  3  is interposed between the fold  330  and the extending portion  350  as the designated grip portion of the sheet grip portion which is formed of the folded layer  304   b . With such a configuration, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the other release sheet  304  (the release sheet  304  on the lower side in  FIG. 25 ) of the release sheet group  380   a  is easily released while passing through the first portion X 1  of the adhesion sheet  2  on the lower surface of the device main body  3 . Namely, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the winding and bending of the second portion X 2  of the adhesion sheet  2  caused by the release operation of the other release sheet  304  (the release sheet  304  on the lower side in  FIG. 25 ) of the release sheet group  380   a  can be suppressed. 
     As described above, according to two release sheets  304  of the release sheet group  380   a , the winding and bending of the second portion X 2  of the adhesion sheet  2  caused by a release operation can be suppressed. In addition, the same effect can be also obtained for the two release sheets  304  of the release sheet group  380   b , which are symmetrical in shape. 
     Hereinafter, items common to four release sheets  304  of the release sheet groups  380   a  and  380   b  will be described. For this reason, unless otherwise specified, the four release sheets  304  will be described without distinction. 
     Attention is paid to each of the release sheets  304 . As illustrated in  FIG. 23  and the like, in a plan view, the holder  21  of the device main body  3 , more specifically, the support portion  24  of the holder  21  is interposed between the fold  330  and the extending portion  350  as the designated grip portion of the sheet grip portion which is formed of the folded layer  304   b . The support portion  24  of the present embodiment extends to surround the cover portion  23  in a plan view. In addition, as illustrated in  FIG. 24  and the like, in a plan view, a part of the support portion  24  (for example, refer to the position of reference sign “ 24   a ” in  FIG. 24 ) of the present embodiment extends from the fold  330  in a direction toward the extending portion  350  as the designated grip portion of the sheet grip portion. As a consequence, when the extending portion  350  as the designated grip portion is moved to the outside of the device main body  3  in a plan view, the release sheet  304  can be released along the first portion X 1  of the adhesion sheet  2  which is located below the support portion  24 . For this reason, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the winding and bending of the second portion X 2  of the adhesion sheet  2  caused by the release operation of the release sheet  304  can be further suppressed. 
     As illustrated in  FIGS. 23 and 24 , in the present embodiment, the extending portions  350  of the two release sheets  304  of the release sheet group  380   a  may be moved in the direction of a white arrow “M1”. In addition, as illustrated in  FIG. 24 , in the present embodiment, the extending portions  350  of the two release sheets  304  of the release sheet group  380   b  may be moved in the direction of a white arrow “M2”. 
     In addition, as illustrated in  FIG. 23  and the like, in the present embodiment, in a plan view, the extending portion  350  as the designated grip portion of the sheet grip portion is formed at a position different from that of the receiving portion  14  defined by the adhesion sheet  2 . As a consequence, in a state where a portion of the insertion device such as a sheath which is inserted into the living body remains received by the receiving portion  14 , the portion extending outside the living body, the extending portion  350  as the designated grip portion of the sheet grip portion can be operated to release the release sheet  304  from the adhesion sheet  2 . 
     Further, as illustrated in  FIG. 23  and the like, in a plan view, the release sheet  304  of the present embodiment is not provided in at least a part of the receiving portion  14  defined by the adhesion sheet  2 . Namely, even in a pre-use state before the release sheet  304  is released, the receiving portion  14  defined by the adhesion sheet  2  can receive the insertion device  100  such as a sheath (refer to  FIG. 10A  and the like) from the outside. 
     Fifth Embodiment 
     Next, an adhesion device  401  in a fifth embodiment will be described with reference to  FIGS. 26 to 30 .  FIG. 26  is a perspective view of the adhesion device  401 .  FIG. 27  is an exploded perspective view of the adhesion device  401 .  FIG. 28  is a top view of the adhesion device  401 .  FIG. 29  is a bottom view of the adhesion device  401 .  FIG. 30  is a view illustrating a release sheet  404  of the adhesion device  401 .  FIG. 30  illustrates a method of forming the release sheet  404 . 
     The adhesion device  401  includes an adhesion sheet  402 , a device main body  403 , and the release sheet  404 . 
     The adhesion sheet  402  is slightly different in shape in a plan view from the adhesion sheet  2  of the first embodiment, and other configurations are the same. The shape of the device main body  403  to be described later is different from the shape of the device main body  3  of the first embodiment. For this reason, the positional relationship in a plan view between the adhesion sheet  402  and the device main body  403  of the present embodiment is different from the positional relationship in a plan view between the adhesion sheet  2  and the device main body  3  of the first embodiment. As illustrated in  FIG. 28  and the like, for example, in a plan view, the adhesion sheet  402  of the present embodiment extends to surround a cover portion  423  of a holder  421  to be described later (i.e., the adhesion sheet  402  surrounds an entirety of the cover portion  423  of the holder  421 ). In addition, as illustrated in  FIG. 28  and the like, in a plan view, a gap G 1  leading to the outside is formed in the adhesion sheet  402  at the position of a part of the periphery surrounding the cover portion  423  of the holder  421  to be described later. 
     The device main body  403  is mounted to a mounting surface  412  of the adhesion sheet  402 . The device main body  403  includes the holder  421  and a compression member  422 . Similar to the compression member  22  of the first embodiment, the compression member  422  of the present embodiment is an inflator  455 . The shape of the holder  421  of the device main body  403  is different from that of the device main body  3  of the first embodiment. Particularly, as illustrated in  FIG. 28 , in a plan view, a support portion  424  of the holder  421  of the present embodiment does not fully surround the periphery of the cover portion  423  (the support portion  424  surrounds the cover portion  423 , but for a gap along one part of the support portion). As illustrated in  FIG. 28  and the like, in a plan view, a gap G 2  leading to the outside is formed in the support portion  424  at the position of a part of the periphery surrounding the cover portion  423 . The gap G 2  is provided at the same position as that of the gap G 1  of the adhesion sheet  402  having a C shape in a plan view. Therefore, in the adhesion device  401  of the present embodiment, a receiving portion  414  which can receive the insertion device  100  such as a sheath (refer to  FIG. 10A  and the like) is formed of the gap G 2  of the support portion  424  of the holder  421  and the gap G 1  of the adhesion sheet  402 . 
     Further, the receiving portion  414  of the present embodiment extends to a central opening region defined by the adhesion sheet  402  having a C shape. Therefore, in the present embodiment, the insertion device  100  such as a sheath (refer to  FIG. 10A  and the like) can be received at the position of the central opening region defined by the adhesion sheet  402  having a C shape. 
     The release sheet  404  releasably adheres to an adhesion surface  411  of the adhesion sheet  402 . When the adhesion device  401  is to be adhered to the biological surface, the release sheet  404  is released from the adhesion surface  411 . Accordingly, the adhesion surface  411  of the adhesion sheet  402  is exposed to the outside, and the adhesion device  401  is in the state of being able to adhere to the biological surface. 
     As illustrated in  FIGS. 26 to 30 , the release sheet  404  includes a release layer  404   a  that adheres to the adhesion surface  411  of the adhesion sheet  402 , and a folded layer  404   b  which is formed of at least one layer (one layer in the present embodiment) and is folded to a side, which is opposite to the adhesion surface  411  with respect to the release layer  404   a , to be layered. 
     As illustrated in  FIG. 26 , the folded layer  404   b  of the release sheet  404  is layered on the release layer  404   a  of the release sheet  404  at least at the position of the second portion X 2  of the adhesion sheet  402 . Since the release sheet  404  has such a configuration, similar to the release sheet  4  of the first embodiment, the release sheet  404  is easily released from the second portion X 2  of the adhesion sheet  402 . 
     As illustrated in  FIG. 27  and the like, in the present embodiment, the entire region of the adhesion surface  411  of the adhesion sheet  402  is covered with two release sheets  404  which are symmetrical in shape.  FIG. 30  illustrates only one release sheet  404  of the two release sheets  404  which are symmetrical in shape. Since the two release sheets  404  are symmetrical in shape, hereinafter, only the one release sheet  404  will be described as an example. As illustrated in  FIG. 30 , the release sheet  404  of the present embodiment is folded once from an original form of a single layer (left figure in  FIG. 30 ) to be shaped into a completed form of two layers (right figure in  FIG. 30 ). In such a manner, the release sheet  404  including the release layer  404   a  which is formed of one layer and the folded layer  404   b  which is formed of one layer is formed. 
     The release sheet  404  of the present embodiment has two folds (fold lines or fold edges)  430  between the release layer  404   a  and the folded layer  404   b . The two folds  430  of the present embodiment are located on the same virtual straight line. Hereinafter, for convenience of description, the two folds  430  are referred as a “first fold  430   a ” and a “second fold  430   b”.    
     As illustrated in  FIG. 29 , in a plan view, the first fold  430   a  passes through the first portion X 1  of the adhesion sheet  402 . As a consequence, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the position of the first portion X 1  of the adhesion sheet  402  can be set as a release start position of the release layer  404   a  of the release sheet  404 . Accordingly, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the winding and bending of the second portion X 2  of the adhesion sheet  402  caused by the release operation of the release sheet  404  can be suppressed. 
     As illustrated in  FIG. 29 , in a plan view, the second fold  430   b  does not pass through the first portion X 1  of the adhesion sheet  402 . However, in a plan view, the second fold  430   b  does not pass through the first portion X 1  and the second portion X 2  of the adhesion sheet  402 . In addition, in a plan view, the second portion X 2  does not intervene between the second fold  430   b  and the first portion X 1  of the adhesion sheet  402 . Therefore, the same effect as that in the first fold  430   a  can be obtained even at the position of the second fold  430   b.    
     Hereinafter, items common to the first fold  430   a  and the second fold  430   b  will be described. For this reason, unless otherwise specified, the first fold  430   a  and the second fold  430   b  are simply referred to as the fold  430  without distinction. 
     In the release sheet  404 , attention is paid to the folded layer  404   b  and the fold  430 . As illustrated in  FIG. 28  and the like, in a plan view, the device main body  403  is interposed between the fold  430  and an extending portion  450  as a designated grip portion of a sheet grip portion which is formed of the folded layer  404   b . With such a configuration, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the release sheet  404  is easily released while passing through the first portion X 1  of the adhesion sheet  402  on a lower surface of the device main body  403 . Namely, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the winding and bending of the second portion X 2  of the adhesion sheet  402  caused by the release operation of the release sheet  404  can be suppressed. 
     More specifically, as illustrated in  FIG. 28  and the like, in a plan view, the holder  421  of the device main body  403 , more specifically, the support portion  424  of the holder  421  is interposed between the fold  430  and the extending portion  450  as the designated grip portion of the sheet grip portion which is formed of the folded layer  404   b . As illustrated in  FIG. 28  and the like, in a plan view, the support portion  424  of the present embodiment extends to surround the cover portion  423 . In addition, as illustrated in  FIG. 29  and the like, in a plan view, a part of the support portion  424  (for example, refer to the position of reference sign “ 424   a ” in  FIG. 29 ) of the present embodiment extends from the fold  430  in a direction toward the extending portion  450  as the designated grip portion of the sheet grip portion. As a consequence, when the extending portion  450  as the designated grip portion is moved to the outside of the device main body  403  in a plan view, the release sheet  404  can be released along the first portion X 1  of the adhesion sheet  402  which is located below the support portion  424 . For this reason, similar to the release sheet  4  (refer to  FIG. 1  and the like) described above, the winding and bending of the second portion X 2  of the adhesion sheet  402  caused by the release operation of the release sheet  404  can be further suppressed. 
     In addition, as illustrated in  FIG. 28  and the like, in the present embodiment, in a plan view, the extending portion  450  as the designated grip portion of the sheet grip portion is formed at a position different from that of the receiving portion  414  defined by the adhesion sheet  402  and the support portion  424 . As a consequence, in a state where a portion of the insertion device such as a sheath which is inserted into the living body remains received by the receiving portion  414 , the portion extending outside the living body, the extending portion  450  as the designated grip portion of the sheet grip portion can be operated to release the release sheet  404  from the adhesion sheet  402 . 
     Further, as illustrated in  FIG. 28  and the like, in a plan view, the release sheet  404  of the present embodiment is located in the gaps G 1  and G 2  described above. Namely, in a plan view, the release sheet  404  of the present embodiment closes the receiving portion  414  defined by the adhesion sheet  402  and the support portion  424 . However, the release sheet  404  has a split  483  at the position of the gaps G 1  and G 2  as the receiving portion  414 . More specifically, two release sheets  404  of the present embodiment are divided at the position of the receiving portion  414 . Namely, the release sheet  404  of the present embodiment has a discontinuous configuration at the position of the receiving portion  414 . For this reason, even in a pre-use state before the release sheet  404  is released, the receiving portion  414  defined by the adhesion sheet  402  and the support portion  424  can receive the insertion device  100  such as a sheath (refer to  FIG. 10A  and the like) from the outside through the split  483  of the release sheet  404 . 
     The adhesion device according to the present disclosure is not limited to the specific configurations described in the embodiments described above, and various modifications and changes can be made without departing from the concept of the present disclosure. For example, an adhesion device configured by appropriately combining the components illustrated in the first to fifth embodiments described above also belongs to the technical scope of the present disclosure. 
       FIG. 34  is a view illustrating a release sheet  604  as a modification example of the release sheet  4  illustrated in  FIG. 5 .  FIG. 34  illustrates a method of forming the release sheet  604 . The configuration of a designated grip portion of the release sheet  604  illustrated in  FIG. 34  is different from that of the release sheet  4  illustrated in  FIG. 5 , and other configurations are the same. The designated grip portion in a folded layer  604   b  as a sheet grip portion of the release sheet  604  illustrated in  FIG. 34  is configured to serve as both the same extending portion as the extending portion  50  illustrated in  FIG. 5  and the same grip guide portion as the grip guide portion  550  illustrated in  FIG. 33 . Hereinafter, for convenience of description, the designated grip portion illustrated in  FIG. 34  is referred to as an “extending grip guide portion  650 ”. The extending grip guide portion  650  is formed of a portion that does not overlap a release layer  604   a , and has a predetermined mark  650   a  which provides a guide on gripping. Examples of the mark  650   a  of the extending grip guide portion  650  illustrated in  FIG. 34  include various symbols, colors, patterns, characters, combinations thereof, and the like which provide a guide on gripping. In  FIG. 34 , as one example, a guide on gripping is provided by indicating the grip range with a line and the grip position with a color, and when the release sheet  604  is released, a direction in which the extending grip guide portion  650  is moved is guided by an arrow. 
       FIG. 35  is a perspective view illustrating a state where instead of the release sheet  4  illustrated in  FIG. 5 , the release sheet  604  illustrated in  FIG. 34  adheres to the adhesion surface  11  of the adhesion sheet  2 . An operator such as a health care worker grips the extending grip guide portion  650  and moves the extending grip guide portion  650  in a direction indicated by a thick arrow in  FIG. 35 . Accordingly, the release sheet  604  can be released from the adhesion surface  11  of the adhesion sheet  2 . As illustrated in  FIGS. 34 and 35 , the extending grip guide portion  650  serving as the extending portion and the grip guide portion is set as the designated grip portion, the operator can easily and intuitively understand the grip position, the operation method, and the like. 
     The detailed description above describes embodiments of an adhesion device, for example a medical adhesion device for applying compression to a puncture site to perform hemostasis, and hemostasis method representing examples of the inventive adhesion device and hemostasis method disclosed here. The invention is not limited, however, to the precise embodiments and variations described. Various changes, modifications and equivalents can be effected by one skilled in the art without departing from the spirit and scope of the invention as defined in the accompanying claims. It is expressly intended that all such changes, modifications and equivalents which fall within the scope of the claims are embraced by the claims.