Patent Publication Number: US-2011065577-A1

Title: Substituted pyridin-4-yl-methyl sulfonamides as fungicides

Description:
The present invention relates to compounds of formula I 
     
       
         
         
             
             
         
       
     
     wherein:
     R a  is halogen, CN, NH 2 , NO 2 , OH, SH, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -haloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl, C 1 -C 6 -haloalkylsulfonyl, C 1 -C 6 -alkylcarbonyl, C 1 -C 6 -haloalkylcarbonyl, C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -haloalkoxycarbonyl, C 1 -C 6 -alkylamino, C 1 -C 6 -haloalkylamino, di(C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -haloalkyl)amino, C 1 -C 6 -alkylaminocarbonyl, di(C 1 -C 6 -alkyl)aminocarbonyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -haloalkynyl, C 3 -C 8 -cycloalkyl or C 1 -C 6 -alkyl-C 3 -C 8 -cycloalkyl; and/or
       two radicals R a  that are bound to adjacent ring member atoms of the pyridine ring may form together with said ring member atoms a fused 5-, 6- or 7-membered saturated, partially unsaturated or aromatic cycle, which may be a carbocycle or heterocycle, wherein the ring member atoms of the fused heterocycle include besides carbon atoms 1, 2, 3 or 4 heteroatoms selected from the group of N, O and S, and wherein the fused carbocycle or heterocycle is unsubstituted or carries 1, 2, 3 or 4 identical or different groups as defined for R a ;   
       n indicates the number of the substituents R a  on the pyridine ring and n is 0, 1, 2, 3 or 4, wherein R a  are identical or different if n is 2, 3 or 4;   R is hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylamino, di(C 1 -C 6 -alkyl)amino, C 1 -C 6 -alkylcarbonyl, C 1 -C 6 -haloalkylcarbonyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -haloalkoxy-C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, C 1 -C 6 -alkyl-C 3 -C 8 -cycloalkyl or benzyl, wherein the phenyl moiety of benzyl is unsubstituted or carries 1, 2, 3, 4, or 5 substituents selected from the group consisting of CN, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylcarbonyl, C 1 -C 6 -haloalkylcarbonyl, C 1 -C 6 -alkoxycarbonyl and di(C 1 -C 6 -alkyl)aminocarbonyl;   A is phenylene or a 5- or 6-membered heteroarenediyl, wherein the ring member atoms of the 5-membered heteroarenediyl include besides carbon atoms 1, 2, 3 or 4 heteroatoms selected from the group of N, O and S and wherein the ring member atoms of the 6-membered heteroarenediyl include besides carbon atoms 2 or 3 nitrogen atoms, and wherein the aforementioned divalent radicals are unsubstituted or carry 1, 2, 3 or 4 identical or different groups R b :
       R b  is halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -haloalkynyl, (C 1 -C 6 -alkyl)carbonyl, (C 1 -C 6 -alkoxy)carbonyl, C 1 -C 6 -alkylamino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)aminocarbonyl and di(C 1 -C 6 -alkyl)aminocarbonyl;   two radicals R b  that are bound to adjacent ring member atoms of the group A may form together with said ring member atoms a fused 5-, 6- or 7-membered saturated, partially unsaturated or aromatic cycle, which may be a carbocycle or heterocycle, wherein the ring member atoms of the fused heterocycle include besides carbon atoms 1, 2, 3 or 4 heteroatoms selected from the group of N, O and S, and wherein the fused carbocycle or heterocycle is unsubstituted or carries 1, 2, 3 or 4 identical or different groups as defined for R b ;   
       Het is a 5- or 6-membered heteroaryl, wherein the ring member atoms of the heteroaryl include besides carbon atoms 1, 2, 3 or 4 heteroatoms selected from the group of N, O and S and wherein the heteroaryl is unsubstituted or carries 1, 2, 3, 4 or 5 identical or different groups R c :
       R c  is halogen, CN, NO 2 , NH 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylamino, di(C 1 -C 6 -alkyl)amino, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -haloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl, C 1 -C 6 -haloalkylsulfonyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -haloalkoxy-C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C(═O)R′, C(═NOR″)R′″, C 3 -C 8 -cycloalkyl, C 1 -C 6 -alkyl-C 3 -C 8 -cycloalkyl, phenyl, phenoxy, phenoxy-C 1 -C 6 -alkyl or a 5- or 6-membered heteroaryl, wherein the ring member atoms of the heteroaryl include besides carbon atoms 1, 2, 3 or 4 heteroatoms selected from the group of N, O and S, and wherein the aforementioned cyclic radicals are unsubstituted or carry 1, 2, 3 or 4 identical or different substituents R d :
           R′ is hydrogen, NH 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxy-C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylamino or di(C 1 -C 6 -alkyl)amino;   R″ is hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl or C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl,   R′″ is hydrogen or C 1 -C 6 -alkyl;   R d  is halogen, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy or C 1 -C 6 -haloalkoxy;   and/or two radicals R c  that are bound to adjacent ring member atoms of the group Het may form together with said ring member atoms a fused 5-, 6- or 7-membered saturated, partially unsaturated or aromatic aromatic cycle, which may be a carbocycle or heterocycle, wherein the ring member atoms of the fused heterocycle include besides carbon atoms 1, 2, 3 or 4 heteroatoms selected from the group of N, O and S, and wherein the fused carbocycle or heterocycle is unsubstituted or carries 1, 2, 3 or 4 identical or different groups R e :   R e  is halogen, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy or C 1 -C 6 -haloalkoxy;
 
and its N-oxides and agriculturally acceptable salts thereof.
   
           
       

     The invention also relates to processes and intermediates for preparing such compounds, to agrochemical compositions comprising a solvent or solid carrier and at least a compound of formula I or an N-oxide or an agriculturally acceptable salt thereof and their use for combating phytopathogenic fungi, and seed comprising a compound of formula I, or an N-oxide or an agriculturally acceptable salt thereof. 
     WO 05/033081 describes pyridin-4-ylmethyl sulfonamides and their use for combating phytopathogenic fungi. WO 06/097489 and WO 08/031,824 describe various pyridin-4-ylmethylamides of biphenyl sulfonic acid and their use as fungicides and insecticides, respectively. WO 07/093,599 and WO 08/022,937 describe pyridin-4-ylmethylamides of pyridiylsulfonic acid and thiophenesulfonic acid, respectively, and their use as fungicides. 
     The compounds according to the present invention differ from those described in WO 05/033081 and WO 06/097489 by having a heteroaryl attached to the cyclic group that is bound to sulfur of the sulfonamide group. 
     With respect to their fungicidal activity, the action of the known compounds is not always completely satisfactory. Based on this, it was an object of the present invention to provide compounds having improved action and/or a broadened activity spectrum against harmful fungi. This object is achieved by substituted pyridin-4-ylmethyl sulfonamides of formula I and its N-oxides and their salts, in particular the agriculturally acceptable salts, as defined herein. 
     The compounds I can be prepared by various routes in analogy to prior art processes known per se for preparing sulfonamides and, advantageously, by the synthesis shown in the following schemes and in the experimental part of this application. 
     A further aspect of the present invention relates to a process for preparing compounds I as defined before, which comprises reacting compounds II, wherein R a , n, and R are defined as above, under basic conditions with compounds III, wherein A and Het are defined as above and L is a nucleophilic leaving group such as halogen, substituted phenoxy, N 3 , heterocyclyl or heterocyclyloxy, preferably pentafluorphenoxy, heterocyclyl such as imazolyl, pyrazolyl or triazolyl, or halogen such as chloro, fluoro or bromo, as shown below: 
     
       
         
         
             
             
         
       
     
     This reaction is usually carried out at temperatures of from −30 to 120° C., preferably from −10 to 100° C., in an inert organic solvent in the presence of a base. 
     Suitable solvents are, in general, aliphatic hydrocarbons, such as pentane, hexane, cyclohexane and petroleum ether, aromatic hydrocarbons, such as toluene, o-, m- and p-xylene, halogenated hydrocarbons, such as dichloromethane (DCM), chloroform and chlorobenzene, ethers, such as diethyl ether, diisopropyl ether, methyl tert-butyl ether (MTBE), dioxane, anisole and tetrahydrofuran (THF), nitriles such as acetonitrile and propionitrile, ketones such as acetone, methyl ethyl ketone, diethyl ketone and tert-butyl methyl ketone, and also dimethyl sulfoxide (DMSO), dimethyl formamide (DMF) and dimethyl acetamide, preferably THF, MTBE, dichloromethane, chloroform, acetonitrile, toluene or DMF, and also mixtures thereof. 
     Suitable bases are, in general, inorganic compounds such as alkali metal and alkaline earth metal hydroxides such as lithium hydroxide, sodium hydroxide, potassium hydroxide and calcium hydroxide, alkali metal and alkaline earth metal oxides such as lithium oxide, sodium oxide, calcium oxide and magnesium oxide, alkali metal and alkaline earth metal hydrides such as lithium hydride, sodium hydride, potassium hydride and calcium hydride, alkali metal and alkaline earth metal carbonates such as lithium carbonate, potassium carbonate and calcium carbonate, and also alkali metal bicarbonates such as sodium bicarbonate, moreover organic bases, e.g. tertiary amines such as trimethylamine, triethylamine, diisopropylethylamine and N-methylpiperidine (NMP), pyridine, substituted pyridines such as collidine, lutidine and 4-dimethylaminopyridine, and also bicyclic amines. Particular preference is given to triethylamine, pyridine, triethylamine and potassium carbonate. The bases are generally employed in catalytic amounts; however, they can also be used in equimolar amounts, in excess or, if appropriate, as solvent. The amount of base is typically 0.5 to 5 molar equivalents relative to 1 mole of compounds II. 
     The starting materials, i.e. compounds II and compounds III, are generally reacted with one another in equimolar amounts. In terms of yield it may be advantageous to employ an excess of compound II based on compound III. 
     Alternatively, compounds IV, wherein R a  and n are as defined above and L′ is a leaving group such as methylsulfonyl, toluenesulfonyl, hydroxyl or a group as defined for L in formula III, preferably, methylsulfonyl, toluenesulfonyl or halogen such as chloro, bromo and iodo, can be reacted with compounds III.a, wherein R, A and Het are as defined above, to obtain directly compounds I as shown below: 
     
       
         
         
             
             
         
       
     
     This reaction can be conducted under similar conditions as described for reacting compounds II with compounds III. Should other leaving groups L′ than hydroxy be desired, the hydroxy group can be effectively reacted to form the leaving group in question, e.g. in situ upon treatment with triphenylphosphine and diethylazodicarboxylate or diisopropylazodicarboxylate or a suitable substitute as described in Organ. Lett. 8, 5069-5072, 2006. 
     Alternatively, this reaction may also be carried in two consecutive steps as shown below, wherein R a , n, R, A and Het are defined as above, R i  and R j  are each independently hydrogen or C 1 -C 4 -alkyl, or R i  and R j  together form an 1,2-ethylene or 1,2-propylene moiety the carbon atoms of which may be unsubstituted or may all or in part be substituted by methyl groups, and L is a suitable leaving group, such as halogen, preferably chlorine, bromine or iodine, alkylcarbonylate, benzoate, alkylsulfonate, haloalkylsulfonate or arylsulfonate, most preferably chlorine or bromine: 
     
       
         
         
             
             
         
       
     
     The first of the abovementioned reaction steps, wherein compounds IV are reacted with compounds V to obtain compounds VI, can be conducted under similar conditions as described for reacting compounds II with compounds III. 
     The second reaction step, wherein compounds VI are reacted with compounds VII, is usually carried out at temperatures of from 20° C. to 180° C., preferably from 40° C. to 120° C. in an inorganic solvent in the presence of a base and a catalyst, in particular a palladium catalyst, such as described e.g. in the following literature: Synth. Commun. Vol. 11, p. 513 (1981); Acc. Chem. Res. Vol. 15, pp. 178-184 (1982); Chem. Rev. Vol. 95, pp. 2457-2483 (1995); Organic Letters Vol. 6 (16), p. 2808 (2004); “Metal catalyzed cross coupling reactions”, 2nd Edition, Wiley, VCH 2005 (Eds. De Meijere, Diederich); “Handbook of organopalladium chemistry for organic synthesis” (Eds Negishi), Wiley, Interscience, New York, 2002; “Handbook of functionalized organometallics”, (Ed. P. Knochel), Wiley, VCH, 2005. 
     Suitable catalysts are, in general, tetrakis(triphenylphosphine)palladium(0); bis(triphenylphosphine)palladium(II) chloride; bis(acetonitrile)palladium(II) chloride; [1,1′-bis(diphenylphosphino)ferrocene]-palladium(II) chloride/methylene chloride (1:1) complex; bis[bis-(1,2-diphenylphosphino)ethane]palla-dium(0); bis(bis-(1,2-diphenylphosphino)butane]-palladium(II) chloride; palladium(II) acetate; palladium(II) chloride; and palladium(II) acetate/tri-o-tolylphosphine complex or mixtures of phosphines and Pd salts or phosphines and Pd-complexes e.g. dibenzylideneacetonepalladium and tritertbutylphosphine (or its tetrafluoroborate), tris cyclohexylphosphine; or a polymer-bound Pd-triphenylphosphine catalyst system. 
     Suitable solvents are, in general, aliphatic hydrocarbons, such as pentane, hexane, cyclohexane and petroleum ether, aromatic hydrocarbons, such as toluene, o-, m- and p-xylene, ethers, such as diisopropyl ether, MTBE, dioxane, anisole and THF and dimethoxyethane, ketones, such as acetone, methyl ethyl ketone, diethyl ketone and tert-butyl methyl ketone, and also DMSO, DMF and dimethylacetamide, particularly preferably ethers, such as THF, dioxane and dimethoxyethane. It is also possible to use mixtures of the solvents mentioned, or mixtures with water. 
     Suitable bases are, in general, inorganic compounds, such as alkali metal and alkaline earth metal oxides, such as lithium oxide, sodium oxide, calcium oxide and magnesium oxide, alkali metal and alkaline earth metal carbonates, such as lithium carbonate, sodium carbonate, potassium carbonate, caesium carbonate and calcium carbonate, and also alkali metal bicarbonates, such as sodium bicarbonate, alkali metal and alkaline earth metal alkoxides, such as sodium methoxide, sodium ethoxide, potassium ethoxide and potassium tert-butoxide, moreover organic bases, for example tertiary amines, such as trimethylamine, triethylamine, diisopropylethylamine and NMP, pyridine, substituted pyridines, such as collidine, lutidine and 4-dimethylaminopyridine, and also bicyclic amines. Particular preference is given to bases such as sodium carbonate, potassium carbonate, caesium carbonate, triethylamine and sodium bicarbonate. 
     The bases are generally employed in catalytic amounts; however, they can also be used in equimolar amounts, in excess or, if appropriate, as solvent. The amount of base is typically 1 to 10 molar equivalents, preferably 1.5 to 5 molar equivalents relative to 1 mole of compounds VI. The amount of he boronic acid VII is used in a 0.2 to 1 molar equivalents, preferably 0.4 to 1 molar equivalents relative to 1 mole of compounds VI. In some cases it may be beneficial for easy purification to use the boronic acid in a substoechiometric amount of from 0.7 to 0.99 molar equivalents per 1 mole of compounds VI. 
     It is also possible to add a scavenger to the reaction mixtures to remove byproducts or unreacted starting materials by binding to those and simple filtration. For details see “Synthesis and purification catalog”, Argonaut, 2003 and literature cited therein. 
     Alternatively, the conditions of Negishi-coupling (F. Diederich, P. Stang, Metal-catalyzed Cross-coupling Reactions, Wiley 1998, p. 1 ff), Stille-coupling (F. Diederich, P. Stang, Metal-catalyzed Cross-coupling Reactions, Wiley 1998, p. 167 ff) or Kumadacoupling (Angew. Chem. Int. Ed 41 (22), 2002, 4176 if) may be applicable for reacting compounds VI with compounds VII. 
     Boronic acids or esters VII are commercially available or can be prepared according to “Science of Synthesis” Vol. 6, Thieme, 2005; WO 02/042275; Synlett 2003, (8) p. 1204; J. Org. Chem., 2003, 68, p. 3729, Synthesis, 2000, p. 442, J. Org. Chem., 1995, 60, p. 750; or “Handbook of functionalized organometallics”, (Ed. P. Knochel), Wiley, VCH, 2005. 
     Compounds VI may also be obtained by reacting compounds VIII, wherein A is as defined above and L 1  and L are leaving goups and have one of the meanings mentioned for L in formula III, preferably being L 1  and L different from each other, with compounds II as shown below: 
     
       
         
         
             
             
         
       
     
     The abovementioned reaction can be conducted under similar conditions as described for reacting compounds II with compounds III. 
     Some compounds II are known from the literature (cf. Bioorg. Med. Chem. 15(7), 2759-2767, 2007; US 2007129547; WO 07/64993), are commercially available or they can be prepared by reactions known in the art e.g. by treatment with ammonia or ammonium acetate in the presence or absence of a suitable iodide salt, such as NaI, KI or tetrabutylammonium iodide, in an analogous fashion to the one described in WO 07/69685. Alternatively, compounds II may be prepared starting from derivatives IV by treatment with a suitable phthalimide salt, preferably K +  or Na +  salt, followed by hydrazine, as illustrated in US 2007129547. 
     Alternatively, compounds II, wherein R is hydrogen, can be prepared by reduction of the corresponding oximes IX.a, nitriles IX.b, or amides IX.c or by reductive amination of the corresponding aldehydes IX.d or ketones IX.e as described below. Appropriate methods therefore are known to those skilled in the art: 
     
       
         
         
             
             
         
       
     
     Methods suitable for the reduction of oximes IX.a, aldehydes IX.d or ketones IX.e to the corresponding compounds II have been described in the literature e.g. in March, J. “Advanced Organic Chemistry: Reactions, Mechanisms, and Structure” (Wiley &amp; Sons, New York, 4th ed., 1992, pp. 1218-1219). 
     Methods suitable for the reduction of nitriles IX.b to the corresponding compounds II have been described in the literature, e.g. in March, J. “Advanced Organic Chemistry: Reactions, Mechanisms, and Structure” (Wiley &amp; Sons, New York, 4th ed., 1992, 918-919). 
     Methods suitable for the reduction of amides IX.c to the corresponding compounds II have been described in the literature, e.g. in March, J. “Advanced Organic Chemistry: Reactions, Mechanisms, and Structure” (Wiley &amp; Sons, New York, 4th ed., 1992, 1212-1213) 
     The oximes IX.a can be prepared prepared by reactions known in the art, e.g. from either the respective aldehydes IX.d, ketones IX.e, or the methyl derivatives IX.f in analogy to methods described by Houben-Weyl, vol. 10/4, Thieme, Stuttgart, 1968; vol. 11/2, 1957; vol E5, 1985; J. Prakt. Chem./Chem. Ztg. 336(8), 695-697, 1994; Tetrahedron Lett. 42(39), 6815-6818, 2001; Heterocycles 29(9), 1741-1760, 1989; or Liebigs Ann. Chem. 737, 39-45, 1970. 
     The aldehydes IX.d can be synthesized from the corresponding methyl derivatives IX.f in analogy to J. Org. Chem. 51(4), 536-537, 1986, or from halogenated derivatives IX.g as shown in Eur. J. Org. Chem. 2003(8), 1576-1588, 2003; Tetrahedron Lett. 40(19), 3719-3722 1999; or Tetrahedron 55(41), 12149-12156, 1999. The ketones IX.e may be prepared by oxidation of the corresponding alcohols using standard agents, e.g. in analogy to the methods described in Synthesis 11, 881-884; or Heterocycles 71(4), 911-918. 
     The nitriles IX.b can be prepared in analogy to methods described in Heterocycles, 41(4), 675 (1995); Chem. Pharm. Bull., 21, 1927 (1973); or J. Chem. Soc., 426 (1942); e.g. from the corresponding halogenated derivatives IX.g by reaction with cyanides such as CuCN, NaCN or KCN or in analogy to the route described in Monatsh. Chem. 87, 526-536, (1956), e.g. from the corresponding halogenated derivatives IX.g by reaction with a trialkylamine to afford the trialkylammonium substituted derivatives, followed by reaction with suitable cyanation reagents such as organic or inorganic cyanides, e.g. tetraalkylammonium cyanides, NaCN or KCN. The compounds IX.g are commercially available or can be synthesized according to standard methods. 
     The amides IX.c can be prepared, e.g. from the corresponding carboxylic acid chlorides or anhydrides by reaction with ammonia, e.g. as described in March, J. “Advanced Organic Chemistry: Reactions, Mechanisms, and Structure” (Wiley &amp; Sons, New York, 3th edition, 1985, 370-371). 
     A further method to obtain compounds II is shown below, wherein PG is a suitable protection group that may be cleaved under acidic, basic or standard hydrogenation conditions such as defined below: 
     
       
         
         
             
             
         
       
     
     Protection of amino groups against reaction during one or more synthesis steps is a procedure well known and described in the art. Examples of suitable protection groups are those which are customarily used in organic synthesis, preferably t-butyloxycarbonyl, benzyloxycarbonyl, allyloxy-carbonyl, diformyl or phthaloyl. Further details on suitable protection groups and their cleavage may be found in Greene T. W., Wits P. G. “Protective groups in organic synthesis” (Wiley &amp; Sons, New York, 1999, 494 et sqq.). The hydrogenation of the nitriles IX.b can be advantageously performed in the presence of suitable catalysts, preferably Raney nickel or palladium-on-carbon, and protection reagents such as di-tert-butyl dicarbonate, dibenzyl dicarbonate, benzyl chloroformate, to yield the N-protected compounds X. On treating with hydrogen chloride or with hydrogen bromide/glacial acetic acid or with trifluoroacetic acid/water mixtures, the compounds X can be deprotected to yield compounds II, wherein R is hydrogen. 
     Compounds IV, wherein L′ is halogen, preferably Cl or Br, may be synthesized under standard halogenation conditions, e.g. by treatment of the corresponding methyl derivative IX.f with halogenation reagents such as Cl 2 , Br 2 , N-chlorosuccinimide, N-bromosuccinimide or isocyanuric chloride in analogy to methods described in Bioorg. Med. Chem. 15(10), 3315-3320; 2007, Eur. J. Org. Chem. 4, 947-957, 2006; J. Med. Chem. 48(5), 1367-1383, 2005; or J. Org. Chem. 68(11), 4179-4188, 2003. 
     Compounds IV, wherein L′ is methylsulfonyl or toluenesulfonyl, may be prepared under standard conditions by reacting the corresponding alcohol with methanesulfonic anhydride or trifluoromethanesulfonic anhydride, respectively, in analogy to methods described in J. Org. Chem. 50, 165-2170, 1985; or J. Chem. Soc. Perkin Trans. 1: Org. Bioorg. Chem. 12, 2887-2894, 1980. 
     The group R may be present in compounds II or may be introduced at a later stage as shown below by standard conditions in analogy to Coll. Czechoslovak. Chem. Comm. 40(4), 1193-1198, 1975 or J. Med. Chem. 19(12), 1409-1416, 1991, upon reaction of compounds I, wherein R is hydrogen, with suitable compounds XI, wherein the R and the leaving group L are as defined above and which compounds XI are known in the art: 
     
       
         
         
             
             
         
       
     
     Compounds III and its derivatives III.a and III.b are known in the art and can be prepared in analogy to methods described in the European patent application 08101694.1. 
     If individual compounds I cannot be obtained by the routes described above, they can be prepared by derivatization of other compounds I. 
     The N-oxides may be prepared from the compounds I according to conventional oxidation methods, e.g. by treating compounds I with an organic peracid such as metachloroperbenzoic acid (cf. WO 03/64572 or J. Med. Chem. 38(11), 1892-903, 1995); or with inorganic oxidizing agents such as hydrogen peroxide (cf. J. Heterocyc. Chem. 18(7), 1305-8, 1981) or oxone (cf. J. Am. Chem. Soc. 123(25), 5962-5973, 2001). The oxidation may lead to pure mono-N-oxides or to a mixture of different N-oxides, which can be separated by conventional methods such as chromatography. 
     If the synthesis yields mixtures of isomers, a separation is generally not necessarily required since in some cases the individual isomers can be interconverted during workup for use or during application (e.g. under the action of light, acids or bases). Such conversions may also take place after use, e.g. in the treatment of plants in the treated plant, or in the harmful fungus to be controlled. 
     The term “compounds I” refers to compounds of formula I. Likewise, this terminology applies to all sub-formulae, e.g. “compounds I.2” refers to compounds of formula I.2 or “compounds II” refers to compounds of formula II. 
     In the definitions of the variables given above, collective terms are used which are generally representative for the substituents in question. The term “C n -C m ” indicates the number of carbon atoms possible in each case in the substituent or substituent moiety in question. 
     The term “halogen” refers to fluorine, chlorine, bromine and iodine. 
     The term “C 1 -C 6 -alkyl” refers to a straight-chained or branched saturated hydrocarbon group having 1 to 6 carbon atoms, e.g. methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, 1,1-dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, hexyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl. Likewise, the term “C 1 -C 4 -alkyl” refers to a straight-chained or branched alkyl group having 1 to 4 carbon atoms. 
     The term “C 1 -C 4 -haloalkyl” refers to a straight-chained or branched alkyl group having 1 to 4 carbon atoms, wherein some or all of the hydrogen atoms in these groups may be replaced by halogen atoms, e.g. chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-bromoethyl, 1-fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl and pentafluoroethyl, 2-fluoropropyl, 3-fluoropropyl, 2,2-difluoropropyl, 2,3-difluoropropyl, 2-chloropropyl, 3-chloropropyl, 2,3-dichloropropyl, 2-bromopropyl, 3-bromopropyl, 3,3,3-trifluoropropyl, 3,3,3-trichloropropyl, CH 2 —C 2 F 5 , CF 2 —C 2 F 5 , CF(CF 3 ) 2 , 1-(fluoromethyl)-2-fluoroethyl, 1-(chloromethyl)-2-chloroethyl, 1-(bromomethyl)-2-bromoethyl, 4-fluorobutyl, 4-chlorobutyl, 4-bromobutyl or nonafluorobutyl. Likewise, the term “C 1 -C 6 -haloalkyl” refers to a straight-chained or branched alkyl group having 1 to 6 carbon atoms, wherein some or all of the hydrogen atoms in these groups may be replaced by halogen atoms. 
     The term “C 1 -C 6 -alkoxy” refers to a straight-chain or branched alkyl group having 1 to 4 carbon atoms which is bonded via an oxygen, at any position in the alkyl group, e.g. OCH 3 , OCH 2 CH 3 , O(CH 2 ) 2 CH 3 , 1-methylethoxy, O(CH 2 ) 3 CH 3 , 1-methyhpropoxy, 2-methylpropoxy or 1,1-dimethylethoxy, O(CH 2 ) 4 —CH 3  or O(CH 2 ) 5 CH 3 . Likewise, the term “C 1 -C 4 -alkoxy” refers to a straight-chain or branched alkyl group having 1 to 4 carbon atoms which is bonded via an oxygen, at any position in the alkyl group. 
     The term “C 1 -C 4 -haloalkoxy” refers to a C 1 -C 4 -alkoxy group, wherein some or all of the hydrogen atoms may be replaced by halogen atoms as mentioned above, e.g. OCH 2 F, OCHF2, OCF 3 , OCH 2 Cl, OCHCl 2 , OCCl 3 , chlorofluoromethoxy, dichlorofluoromethoxy, chlorodifluoromethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2-bromoethoxy, 2-iodoethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, 2-chloro-2-fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2-dichloro-2-fluoroethoxy, 2,2,2-trichloro ethoxy, OC 2 F 5 , 2-fluoropropoxy, 3-fluoropropoxy, 2,2-difluoropropoxy, 2,3-difluoro propoxy, 2-chloropropoxy, 3-chloropropoxy, 2,3-dichloropropoxy, 2-bromo propoxy, 3-bromopropoxy, 3,3,3-trifluoropropoxy, 3,3,3-trichloropropoxy, OCH 2 —C 2 F 5 , OCF 2 —C 2 F 5 , 1-difluoromethyl-2-fluoroethoxy, 1-dichloromethyl-2-chloroethoxy, 1-dibromomethyl-2-bromo ethoxy, 4-fluorobutoxy, 4-chlorobutoxy, 4-bromobutoxy or nonafluorobutoxy. Likewise, the term “C 1 -C 6 -haloalkoxy” refers to a C 1 -C 6 -alkoxy group, wherein some or all of the hydrogen atoms may be replaced by halogen atoms. 
     The term “C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl” refers to alkyl having 1 to 4 carbon atoms, wherein one hydrogen atom of the alkyl radical is replaced by a C 1 -C 4 -alkoxy group. Likewise, the term “C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl” refers to alkyl having 1 to 6 carbon atoms, wherein one hydrogen atom of the alkyl radical is replaced by a C 1 -C 6 -alkoxy group. 
     The term “C 1 -C 4 -haloalkoxy-C 1 -C 4 -alkyl” refers to alkyl having 1 to 4 carbon atoms, wherein one hydrogen atom of the alkyl radical is replaced by a C 1 -C 4 -haloalkoxy group. Likewise, the term “C 1 -C 6 -haloalkoxy-C 1 -C 6 -alkyl” refers to alkyl having 1 to 6 carbon atoms, wherein one hydrogen atom of the alkyl radical is replaced by a C 1 -C 6 -alkoxy group. 
     The term “C 1 -C 6 -alkoxy-C 1 -C 6 -alkoxy” refers to an C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl group, which is bonded via an oxygen atom to the remainder of the molecule. 
     The term “C 1 -C 4 -alkylthio” as used herein refers to straight-chain or branched alkyl groups having 1 to 4 carbon atoms bonded via a sulfur atom, at any position in the alkyl group, e.g. methylthio, ethylthio, propylthio, isopropylthio, and n-butylthio. Likewise, the term “C 1 -C 6 -alkylthio” as used herein refers to straight-chain or branched alkyl groups having 1 to 6 carbon atoms bonded via a sulfur atom. Accordingly, the terms “C 1 -C 4 -haloalkylthio” and “C 1 -C 6 -haloalkylthio” refer to straight-chain or branched haloalkyl groups having 1 to 4 or 1 to 6 carbon atoms bonded through a sulfur atom, at any position in the haloalkyl group. 
     The terms “C 1 -C 4 -alkylsulfinyl” and “C 1 -C 6 -alkylsulfinyl”, respectively refer to straight-chain or branched alkyl groups having 1 to 4 or 1 to 6 carbon atoms, respectively, bonded through a —S(═O)— moiety, at any position in the alkyl group, e.g. methylsulfinyl and ethylsulfinyl, and the like. Accordingly, the terms “C 1 -C 4 -haloalkylsulfinyl” and “C 1 -C 6 -haloalkylsulfinyl”, respectively, refer to straight-chain or branched haloalkyl groups having 1 to 4 and 1 to 6 carbon atoms, respectively, bonded through a —S(═O)— moiety, at any position in the haloalkyl group. 
     The terms “C 1 -C 4 -alkylsulfonyl” and “C 1 -C 6 -alkylsulfonyl”, respectively, refer to straight-chain or branched alkyl groups having 1 to 4 and 1 to 6 carbon atoms, respectively, bonded through a —S(═O) 2 — moiety, at any position in the alkyl group, e.g. methylsulfonyl. Accordingly, the terms “C 1 -C 4 -haloalkylsulfonyl” and “C 1 -C 6 -haloalkylsulfonyl”, respectively, refer to straight-chain or branched haloalkyl groups having 1 to 4 and 1 to 6 carbon atoms, respectively, bonded through a —S(═O) 2 — moiety, at any position in the haloalkyl group. 
     The term “C 1 -C 4 -alkylamino” refers to an amino radical carrying one C 1 -C 4 -alkyl group as substituent, e.g. methylamino, ethylamino, propylamino, 1-methylethylamino, butylamino, 1-methylpropylamino, 2-methylpropylamino, 1,1-dimethylethylamino and the like. Likewise, the term “C 1 -C 6 -alkylamino” refers to an amino radical carrying one C 1 -C 6 -alkyl group as substituent. 
     The term “di(C 1 -C 4 -alkyl)amino” refers to an amino radical carrying two identical or different C 1 -C 4 -alkyl groups as substituents, e.g. dimethylamino, diethylamino, di-n-propylamino, diisopropylamino, N-ethyl-N-methylamino, N-(n-propyl)-N-methylamino, N-(isopropyl)-N methylamino, N-(n-butyl)-N-methylamino, N-(n-pentyl)-N-methylamino, N-(2-butyl)-N methylamino, N-(isobutyl)-N-methylamino, and the like. Likewise, the term “di(C 1 -C 6 -alkyl)amino” refers to an amino radical carrying two identical or different C 1 -C 6 -alkyl groups as substituents. 
     Accordingly, the terms “C 1 -C 6 -haloalkylamino” and “di(C 1 -C 4 -haloalkyl)amino”, respectively, refer to amino radicals carrying one and two identical or different C 1 -C 6 -alkyl groups as substituents, respectively. 
     The term “C 1 -C 4 -alkylcarbonyl” refers to a C 1 -C 6 -alkyl radical which is attached via a carbonyl group. The term “(C 1 -C 6 -alkoxy)carbonyl” refers to a C 1 -C 6 -alkoxy radical which is attached via a carbonyl group. Accordingly, the terms “C 1 -C 6 -haloalkylcarbonyl” and “C 1 -C 6 -haloalkoxycarbonyl”, respectively, refer to a C 1 -C 6 -alkyl radical and a C 1 -C 6 -alkoxy radical, respectively, which are attached via a carbonyl group. 
     The term “C 1 -C 6 -alkylaminocarbonyl” refers to a C 1 -C 6 -alkylamino radical which is attached via a carbonyl group. Likewise, the term “di(C 1 -C 6 -alkyl)aminocarbonyl” refers to a di(C 1 -C 6 )alkylamino radical which is attached via a carbonyl group. 
     The term “phenoxy” and refers to a phenyl radical which is attached via an oxygen atom. Likewise, the term “phenoxy-C 1 -C 6 -alkyl” and refers to a phenoxy radical which is attached via a C 1 -C 6 -alkyl group. 
     The term “C 2 -C 4 -alkenyl” refers to a straight-chain or branched unsaturated hydrocarbon radical having 2 to 4 carbon atoms and a double bond in any position, e.g. ethenyl, 1-propenyl, 2-propenyl(allyl), 1-methylethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl. Likewise, the term “C 2 -C 6 -alkenyl” refers to a straight-chain or branched unsaturated hydrocarbon radical having 2 to 6 carbon atoms and a double bond in any position. 
     The term “C 2 -C 4 -alkynyl” refers to a straight-chain or branched unsaturated hydrocarbon radical having 2 to 4 carbon atoms and containing at least one triple bond, such as ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl. Likewise, the term “C 2 -C 6 -alkynyl” refers to a straight-chain or branched unsaturated hydrocarbon radical having 2 to 6 carbon atoms and at least one triple bond. 
     The term “C 3 -C 10 -cycloalkyl” refers to monocyclic, bicyclic, bridged and diamandoid saturated hydrocarbon radicals having 3 to 10 carbon ring members, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, cyclodecyl, norbornyl or adamantyl. 
     Likewise, the term “C 3 -C 10 -cycloalkenyl” refers to monocyclic, bicyclic and bridged unsaturated hydrocarbon radicals having 3 to 10 carbon ring members and a double bond in any position, such as cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, cyclooctenyl, cyclononenyl, cyclodecenyl or norbornenyl. 
     The term “C 1 -C 6 -alkyl-C 3 -C 8 -cycloalkyl” refers to a cycloalkyl radical having 3 to 8 carbon atoms (as defined above), wherein one hydrogen atom of the cycloalkyl radical is replaced by a C 1 -C 6 -alkyl group. 
     The term “5-, 6- or 7-membered carbocycle” is to be understood as meaning both saturated or partially unsaturated carbocycles having 5, 6 or 7 ring members as well as phenyl. Examples for non-aromatic rings include cyclopentyl, cyclopentenyl, cyclopentadienyl, cyclohexyl, cyclohexenyl, cyclohexadienyl, cycloheptyl, cycloheptenyl, cycloheptadienyl, and the like. 
     The term “5-, 6-, or 7-membered heterocycle” wherein the ring member atoms of the heterocycle include besides carbon atoms one, two, three or four heteroatoms selected from the group of N, O and S, is to be understood as meaning both saturated and partially unsaturated as well as aromatic heterocycles having 5, 6 or 7 ring atoms. 
     Examples Include: 
     
         
         
           
             saturated and partially unsaturated 5-, 6-, or 7-membered heterocycle wherein the ring member atoms of the heterocycle include besides carbon atoms 1, 2 or 3 heteroatoms selected from the group of N, O and S, and which is saturated or partially unsaturated, e.g. pyrrolidin-2-yl, pyrrolidin-3-yl, tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, tetrahydrothien-2-yl, tetrahydrothien-3-yl, 1,3-dioxolan-4-yl, isoxazolidin-3-yl, isoxazolidin-4-yl, isoxazolidin-5-yl, isothiazolidin-3-yl, isothiazolidin-4-yl, isothiazolidin-5-yl, pyrazolidin-3-yl, pyrazolidin-4-yl, pyrazolidin-5-yl, oxazolidin-2-yl, oxazolidin-4-yl, oxazolidin-5-yl, thiazolidin-2-yl, thiazolidin-4-yl, thiazolidin-5-yl, imidazolidin-2-yl, imidazolidin-4-yl, 2-pyrrolin-2-yl, 2-pyrrolin-3-yl, 3-pyrrolin-2-yl, 3-pyrrolin-3-yl, piperidin-2-yl, piperidin-3-yl, piperidin-4-yl, 1,3-dioxan-5-yl, tetrahydropyran-2-yl, tetrahydropyran-4-yl, tetrahydrothien-2-yl, hexahydropyridazin-3-yl, hexahydropyridazin-4-yl, hexahydropyrimidin-2-yl, hexahydropyrimidin-4-yl, 5-hexahydropyrimidinyl and piperazin-2-yl; 
             5-membered heteroaryl (heteroaromatic radical), wherein the ring member atoms of the heteroaryl include besides carbon atoms 1, 2 or 3 heteroatoms selected from the group of N, O and S, e.g. pyrrol-1-yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan-2-yl, furan-3-yl, pyrazol-1-yl, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1-yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, 1,2,4-triazolyl-1-yl, 1,2,4-triazol-3-yl 1,2,4-triazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl, 1,2,4-thiadiazol-3-yl and 1,2,4-thiadiazol-5-yl; 
             6-membered heteroaryl (heteroaromatic radical), wherein the ring member atoms of the heteroaryl include besides carbon atoms 1, 2 or 3 nitrogen atoms, e.g. pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrazin-2-yl and 1,3,5-triazin-2-yl. 
           
         
       
    
     Furthermore, the term “5- or 6-membered heteroarenediyl” refers to a divalent radical derived from an aromatic heteroaryl having two points of attachment. Examples of heteroarenediyl radicals are, e.g. divalent radicals derived from pyridine, pyrimidine, pyridazine, 1,2,3-triazine, 1,2,4-triazine, 1,2,3,4-tetrazine, furan, thiophene, pyrrole, thiazole, thiadiazole, pyrazole, imidazole, triazole, tetrazole, oxazole, isoxazole, isothiazole, oxadiazole and the like. The aforementioned groups can be C-attached or N-attached where such is possible; e.g. a group derived from pyrrole, imidiazole or pyrazole can be N-attached or C-attached. 
     The term “phenylene” refers to 1,2-phenylene (o-phenylene), 1,3-phenylene (m-phenylene) and 1,4-phenylene (p-phenylene). 
     The term “two radicals R a  that are bound to adjacent ring member atoms of the pyridine ring may form together with said ring member atoms a fused 5-, 6- or 7-membered saturated, partially unsaturated or aromatic cycle” refers to a condensed bicyclic ring system, wherein the pyridine ring carries a fused-on 5-, 6- or 7-membered carbocyclic or heterocyclic ring. 
     The term “two radicals R b  that are bound to adjacent ring member atoms of the group A may form together with said ring member atoms a fused 5-, 6- or 7-membered saturated, partially unsaturated or aromatic cycle” refers to a condensed bicyclic ring system, wherein the 5- or 6-membered heteroarenediyl and phenylene, respectively carry a fused-on 5-, 6- or 7-membered carbocyclic or heterocyclic ring. 
     The term “two radicals R c  that are bound to adjacent ring member atoms of the group Het may form together with said ring member atoms a fused 5-, 6- or 7-membered saturated, partially unsaturated or aromatic aromatic cycle, which may be a carbocycle or heterocycle” refers to a condensed bicyclic ring system, wherein the 5- or 6-membered heteroaryl carries a fused-on 5-, 6- or 7-membered carbocyclic or heterocyclic ring. 
     Agriculturally acceptable salts of compounds I encompass especially the salts of those cations or the acid addition salts of those acids whose cations and anions, respectively, have no adverse effect on the fungicidal action of the compounds I. Suitable cations are thus in particular the ions of the alkali metals, preferably sodium and potassium, of the alkaline earth metals, preferably calcium, magnesium and barium, of the transition metals, preferably manganese, copper, zinc and iron, and also the ammonium ion which, if desired, may carry one to four C 1 -C 4 -alkyl substituents and/or one phenyl or benzyl substituent, preferably diisopropylammonium, tetramethylammonium, tetrabutylammonium, trimethylbenzylammonium, furthermore phosphonium ions, sulfonium ions, preferably tri(C 1 -C 4 -alkyl)sulfonium, and sulfoxonium ions, preferably tri(C 1 -C 4 -alkyl)sulfoxonium. Anions of useful acid addition salts are primarily chloride, bromide, fluoride, hydrogensulfate, sulfate, dihydrogenphosphate, hydrogenphosphate, phosphate, nitrate, bicarbonate, carbonate, hexafluorosilicate, hexafluorophosphate, benzoate, and the anions of C 1 -C 4 -alkanoic acids, preferably formate, acetate, propionate and butyrate. They can be formed by reacting a compound of formula I with an acid of the corresponding anion, preferably of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid or nitric acid. 
     The compounds of formula I can be present in atropisomers arising from restricted rotation about a single bond of asymmetric groups. They also form part of the subject matter of the present invention. 
     Depending on the substitution pattern, the compounds of formula I and their N-oxides may have one or more centers of chirality, in which case they are present as pure enantiomers or pure diastereomers or as enantiomer or diastereomer mixtures. Both, the pure enantiomers or diastereomers and their mixtures are subject matter of the present invention. 
     In respect of the variables, the embodiments of the intermediates correspond to the embodiments of the compounds I. 
     Preference is given to those compounds I and where applicable also to compounds of all sub-formulae provided herein, e.g. formulae I.1 and I.2 and to the intermediates such as compounds II, III, IV and IX.a to IX.h, wherein the substituents and variables (m, R, A, Het, R a , R b , R c , R d , R e , R′, R″ and R′″) have independently of each other or more preferably in combination the following meanings: 
     One embodiment of the invention relates to compounds I, wherein n is 1, 2, 3 or 4, more preferably n is 1 or 2. Another embodiment relates to compounds I, wherein n is 2 and R a  is position 2 and 3 of the pyridine ring. A further embodiment relates to compounds I, wherein n is 2 and R a  is position 2 and 6 of the pyridine ring. A further embodiment relates to compounds I, wherein n is 2 and R a  is in position 3 and 5 of the pyridine ring. A further embodiment relates to compounds I, wherein n is 3. A further embodiment relates to compounds I, wherein n is 1. A further embodiment relates to compounds I, wherein n is 0. 
     A further embodiment relates to compounds I, wherein two radicals R a  that are bound to adjacent ring member atoms of the pyridine ring do not form together with said ring member atoms any fused cycle. 
     In one embodiment of the invention, R a  is halogen, CN, NH 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, C 1 -C 6 -alkylamino, C 1 -C 6 -haloalkylamino, di(C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -haloalkyl)-amino, C 1 -C 6 -alkylcarbonyl, C 1 -C 6 -haloalkylcarbonyl, C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -haloalkoxycarbonyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 6 -alkylaminocarbonyl, di(C 1 -C 6 -alkyl)-aminocarbonyl. 
     In another embodiment, R a  is halogen, CN, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 3 -C 8 -cycloalkyl or C 1 -C 4 -alkyl-C 3 -C 8 -cycloalkyl. 
     In a further embodiment, R a  is halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 1 -C 4 -alkylthio or di(C 1 -C 4 -alkyl)amino. 
     In a further embodiment, R a  is selected from F, Cl, Br, OH, SH, CN, C 1 -C 2 -alkyl, cyclopropyl, CH═CH 2 , C≡CH, C 1 -C 2 -alkoxy, methylthio, methylamino, dimethylamino, CF 3 , CHF 2 , OCF 3  and OCHF 2 , more preferably selected from F, Cl, Br, CN, C 1 -C 2 -alkyl, C 1 -C 2 -alkoxy, CF 3 , CHF 2 , OCF 3  and OCHF 2 , and particularly preferred selected from Cl, CH 3 , and OCH 3 . 
     In a further embodiment, R a  is Cl, CN, CH 3 , CF 3 , OCH 3 , OCF 3 , N(CH 3 ) 2 , C 1 -C 6 -alkylcarbonyl and preferably selected from C(═O)CH 3 , C(═O)CH(CH 3 ) 2  and C(═O)C(CH 3 ) 3 , C 1 -haloalkylcarbonyl, in particular C(═O)CF 3 , C 1 -C 4 -alkoxycarbonyl and preferably selected from C(═O)OCH 3 , C(═O)OCH(CH 3 ) 2  and C(═O)OC(CH 3 ) 3 , C 1 -haloalkoxycarbonyl, in particular C(═O)OCF 3 , C 1 -C 6 -alkylaminocarbonyl and preferably selected from C(═O)NHCH 3 , C(═O)NHCH(CH 3 ) 2  and C(═O)NHC(CH 3 ) 3 , di(C 1 -C 6 -alkyl)aminocarbonyl and preferably selected from C(═O)N(CH 3 ) 2 , C(═O)N[CH(CH 3 ) 2 ] 2  and C(═O)N[C(CH 3 ) 3 ] 2 . 
     In a further embodiment, R a  is CH 2 CH 3 , CH 2 (CH 3 ) 2 , CF 3 , OCH 3 , OCH 2 CH 3 , isopropoxy, OCF 3 , OCHF 2 , NHCH 3 , N(CH 3 ) 2 , NHCH 2 CH 3  or NHCH 2 (CH 3 ) 2 . 
     In a further embodiment, R a  is CH 2 CH 3 , CH 2 (CH 3 ) 2 , CF 3 , OCH 2 CH 3 , isopropoxy, OCF 3 , OCHF 2 , N(CH 3 ) 2 , NHCH 2 CH 3  or NHCH 2 (CH 3 ) 2 . 
     In a further embodiment, R a  is halogen and preferably selected from F and Cl and in particular, R a  is Cl. In a further embodiment, R a  is CN. In a further embodiment, R a  is C 1 -C 6 -alkyl and preferably selected from methyl, ethyl, n-propyl, i-propyl and t-butyl. In a further embodiment, R a  is C 1 -C 6 -haloalkyl. More preferably, R a  is C 1 -haloalkyl and selected from fluormethyl, difluormethyl, trifluormethyl, chlormethyl, dichlormethyl and trichlormethyl, and in particular, R a  is trifluormethyl. In a further embodiment, R a  is C 1 -C 4 -alkoxy and preferably selected from methoxy, ethoxy, n-propyloxy and i-propyloxy, and in particular methoxy. A further embodiment relates to compounds I, wherein n is 2 and R a  is in position 2 and 3 of the pyridine ring and is selected from halogen, C 1 -C 2 -alkyl, C 1 -C 2 -alkoxy, C 1 -C 2 -haloalkyl or C 1 -C 2 -haloalkoxy. 
     A further embodiment relates to compounds I, wherein n is 2 and R a  is in position 2 and 3 of the pyridine ring and is selected from Cl, F, CH 3 , OCH 3  or C 2 H 5 . 
     In a further embodiment, two radicals R a  that are bound to adjacent ring member atoms of the pyridine ring form together with said ring member atoms a fused 5-, 6- or 7-membered saturated, partially unsaturated or aromatic aromatic cycle, which may be a carbocycle or heterocycle, wherein the ring member atoms of the fused heterocycle include besides carbon atoms one, two, three or four heteroatoms selected from the group of N, O and S, and wherein the fused carbocycle or heterocycle is unsubstituted and carries 1, 2, 3 or 4 identical or different groups as defined for R a . In one embodiment, the fused cycle is preferably phenyl. In a another embodiment, the fused cycle is preferably a saturated carbocycle and in particular cyclohexyl. In a further embodiment, the fused cycle is preferably a partially unsaturated carbocycle and in particular cyclohexenyl. 
     A further embodiment relates to compounds I, wherein the moiety 
     
       
         
         
             
             
         
       
     
     wherein * indicates the bond to the methylene bridge bound to the nitrogen atom of the sulfonamide group, is selected from quinolin-4-yl, 1,8-naphthyridin-4-yl, 1,7-naphthyridin-4-yl, 1,6-naphthyridin-4-yl, 1,5-naphthyridin-4-yl, pyrido-[2,3-d]pyrimidin-5-yl and pyrido[3,2-d]pyrimidin-8-yl, it being possible for the pyridin-4-yl ring to carry 1 or 2 further radicals R a  and it being possible for the fused-on ring to carry 1 or 2 radicals selected from the group consisting of halogen, C 1 -C 4 -alkyl, halomethyl, C 1 -C 4 -alkoxy or halomethoxy. Particular preference is given to compounds I, wherein the pyridin-4-yl moiety shown above is quinolin-4-yl. Another embodiment relates to compounds I, wherein the pyridin-4-yl moiety shown above is 5,6,7,8-tetrahydroquinolin-4-yl. A further embodiment relates to compounds I, wherein the pyridin-4-yl moiety shown above is 2,3-dihydrofuro[2,3-b]pyridin-4-yl. A further embodiment relates to compounds I, wherein the pyridin-4-yl moiety shown above is 2,3-dihydrofuro[3,2-b]pyridin-4-yl. 
     Specific embodiments relate to compounds I, wherein R a1 , R a2 , R a3  and R a4  are each independently hydrogen or have one of the definitions specified for R a  and wherein the pyridyl group carries one of the following combinations of the radicals R a1 , R a2  and R a3  as defined in Table P, which compounds are of formula I.1 
                     TABLE P                  I.1.                                                                           line   R a1     R a2     R a3     R a4                         P-1   H   H   H   H           P-2   F   H   H   H           P-3   Cl   H   H   H           P-4   CH 3     H   H   H           P-5   OCHF 2     H   H   H           P-6   H   F   H   H           P-7   H   Cl   H   H           P-8   H   CH 3     H   H           P-9   H   C 2 H 5     H   H           P-10   H   OCH 3     H   H           P-11   H   OC 2 H 5     H   H           P-12   CH 3     CH 3     H   H           P-13   OCH 3     CH 3     H   H           P-14   CH 3     OCH 3     H   H                        
wherein % indicates the point of attachment to the pyridine ring at the position of the R a1  substituent; and # indicates the point of attachment to the pyridine ring at the position of the R a2  substituent.
 
     One embodiment relates to compounds I, wherein R is hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkylcarbonyl or C 1 -C 6 -haloalkylcarbonyl, preferably hydrogen or C 1 -C 6 -alkyl. 
     Another embodiment relates to compounds I, wherein R is hydrogen, C 1 -C 4 -alkyl, C 1 -C 2 -haloalkoxy, di(C 1 -C 2 -alkyl)amino, allyl or propargyl. 
     A further embodiment relates to compounds I, wherein R is hydrogen, C 1 -C 4 -alkyl, —CH═CH 2 , —CH 2 —CH═CH 2  or —CH 2 —C≡CH. 
     A further embodiment relates to compounds I, wherein R is C 1 -C 4 -alkyl and preferably selected from methyl, ethyl, n-propyl and i-propyl, and in particular, R is methyl. 
     A further embodiment relates to compounds I, wherein R is hydrogen and wherein R a1 , R a2  and R a3  are each independently hydrogen or have one of the definitions specified for R a , especially those being preferred, which compounds are of formula I.2 
     
       
         
         
             
             
         
       
     
     One embodiment relates to compounds I, wherein A is phenylene, which ist unsubstituted or carries one, two, three or four identical or different substituents R b , with 1,3-phenylene or 1,4-phenylene being preferred. 
     Another embodiment relates to compounds I, wherein A is 1,4-phenylene, which is unsubstituted or carries 1, 2, 3 or 4 identical or different substituents R b , in particular A is 1,4-phenylene, which is unsubstituted. 
     A further embodiment relates to compounds I, wherein A is a heteroarenediyl selected from the group consisting of pyrimidindiyl, pyridazindiyl, pyrazindiyl, triazindiyl, furandiyl, thiendiyl, pyrroldiyl, pyrazoldiyl, isoxazoldiyl, isothiazoldiyl, imidazoldiyl, oxazoldiyl, thiazoldiyl, triazoldiyl, thiadiazoldiyl and oxadiazoldiyl, and wherein the aforementioned radicals are unsubstituted or carry 1, 2 or 3 identical or different substituents R b . If one point of attachment is located on a nitrogen atom of the heteroarenediyl radical, said nitrogen atom is attached either to the sulfur atom of the sulfonamide group or to Het, with the point of attachment to Het being more preferred. 
     A further embodiment relates to compounds I, wherein A is a 6-membered heteroarenediyl, which is unsubstituted or carries 1, 2, 3 or 4 identical or different substituents R b . Amongst compounds I, wherein A is a 6-membered heteroarenediyl, particular preference given to those, wherein A is pyrimidinyl, pyridazinyl or pyrazinyl, wherein each of the aforementioned two radicals are unsubstituted or carry 1, 2 or 3 identical or different substituents R b . 
     A further embodiment relates to compounds I, wherein A is a 5-membered heteroarenediyl, which is unsubstituted or carries 1, 2, 3 or 4 identical or different substituents R b . Amongst compounds I, wherein A is a 5-membered heteroarenediyl, particular preference given to those, wherein A is thiendiyl, thiazoldiyl, oxazoldiyl, pyrazoldiyl or pyridindiyl, wherein each of the aforementioned five radicals are unsubstituted or carry 1, 2 or 3 identical or different substituents R b . 
     Particularly preferred embodiments of the invention relate to compounds I, in which A is one of the following radicals A-1 to A-6: 
                                             No.   A                          A-1                                             A-2                                             A-3                                             A-4                                             A-5                                             A-6                                              
wherein # indicates the bond to the sulfur atom of the sulfonamide group; and * indicates the bond to Het.
 
     One embodiment of the invention relates to compounds I, wherein the group A carries 1, 2 or 3 radicals R b , more preferably 1 or 2 radicals R b . In another embodiment, the group A is unsubstituted or carries 1 radical R b . In a further embodiment, the group A is unsubstituted. In a further embodiment, the group A carries 1 radical R b . In a further embodiment, the group A carries 2 radicals R b . In a further embodiment, the group A carries 3 radicals R b . 
     If R b  is present, R b  is preferably halogen, CN, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 2 -C 4 -alkenyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -alkynyl, C 2 -C 4 -haloalkynyl, C 1 -C 4 -alkylcarbonyl, C 1 -C 4 -alkoxycarbonyl, C 1 -C 4 -alkylamino, di(C 1 -C 4 -alkyl)amino, C 1 -C 4 -alkylaminocarbonyl or di(C 1 -C 4 -alkyl)aminocarbonyl. More preferably, R b  is halogen, CN, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy or C 1 -C 4 -haloalkoxy. Another embodiment relates to compounds I, wherein R b  is halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl or C 1 -C 4 -alkoxy. A further embodiment relates to compounds I, wherein R b  is halogen, CN, C 1 -C 2 -alkyl, C 1 -C 2 -haloalkyl or C 1 -C 2 -alkoxy. A further embodiment relates to compounds I, wherein R b  is F, Cl, CN, CH 3 , OCH 3 , CF 3  or OCHF 2 . A further embodiment relates to compounds I, wherein R b  is OCH 3  or CH 3 . 
     In a further embodiment, R b  is halogen and preferably selected from fluorine and chlorine, and in particular, chlorine. In a further embodiment, R b  is CN. In a further embodiment, R b  is C 1 -C 4 -alkyl and preferably selected from methyl, ethyl, n-propyl and i-propyl, and in particular, methyl. In a further embodiment, R b  is C 1 -C 4 -haloalkyl. More preferably, R b  is C 1 -haloalkyl and selected from fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl and trichloromethyl, and in particular, trifluoromethyl. In a further embodiment, R b  is C 1 -C 4 -alkoxy and preferably selected from methoxy and ethoxy. 
     A further embodiment relates to compounds I, wherein two radicals R b  that are bound to adjacent ring member atoms of the group A form together with said ring member atoms a fused cycle being a fused 5-, 6- or 7-membered saturated, partially unsaturated or aromatic carbocycle or heterocycle, wherein the ring member atoms of the fused heterocycle include besides carbon atoms 1, 2, 3 or 4 heteroatoms selected from the group of N, O and S, and wherein the fused cycle is unsubstituted and carries 1, 2, 3 or 4 identical or different groups as defined for R b . In one embodiment, the fused cycle is preferably phenyl. In another embodiment, the fused cycle is preferably a saturated carbocycle and in particular cyclohexyl. In a further embodiment, the fused cycle is preferably a partially unsaturated carbocycle and in particular cyclohexenyl. 
     One embodiment relates to compounds I, wherein Het is selected from pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, thiazolyl, oxazolyl, isothiazolyl, isoxazolyl, thienyl, furyl, 1,3,5-triazinyl, 1,2,4-triazinyl, thiadiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, pyrazolyl, and imidazolyl, wherein the aforementioned radicals are unsubstituted or carry 1, 2, 3 or 4 identical or different groups R c . 
     Another embodiment relates to compounds I, wherein Het is selected from pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, thiazolyl, 1,3,5-triazinyl and 1,2,4-triazinyl, wherein the aforementioned radicals are unsubstituted or carry 1 or 2 identical or different groups R c . 
     A further embodiment relates to compounds I, wherein Het is selected from pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, thiazol-2-yl, pyrazin-2-yl, pyridazin-3-yl, 1,3,5-triazin-2-yl, and 1,2,4-triazin-3-yl, wherein the aforementioned radicals are unsubstituted or carry 1, 2, 3 or 4 identical or different groups R c . 
     A further embodiment relates to compounds I, wherein Het is a 6-membered heteroaryl, wherein the 6-membered heteroaryl is unsubstituted or carries 1, 2, 3 or 4 identical or different groups R c . 
     In one embodiment, Het is a pyridyl radical that is preferably selected from pyridin-2-yl and pyridin-3-yl, and wherein the aforementioned pyridyl radicals are unsubstituted or carry 1, 2, 3 or 4 identical or different substituents R c . In another embodiment, Het is a pyridin-2-yl radical that is substituted by 1 or 2 identical or different substituents R c . In a more preferred embodiment, Het is selected from 3-trifluoromethylpyridin-2-yl, 4-trifluoromethylpyridin-2-yl, 5-trifluoromethylpyridin-2-yl, 3-chloropyridin-2-yl, 4-chloropyridin-2-yl, 5-chloropyridin-2-yl, 3-cyanopyridin-2-yl, 4-cyanopyridin-2-yl, 5-cyanopyridin-2-yl, 3-nitropyridin-2-yl, 4-nitropyridin-2-yl, 5-nitropyridin-2-yl, 3-methoxycarbonylpyridin-2-yl, 4-methoxycarbonylpyridin-2-yl, 5-methoxycarbonylpyridin-2-yl, 3-aminocarbonylpyridin-2-yl, 4-aminocarbonylpyridin-2-yl, 5-aminocarbonylpyridin-2-yl, 3-methoxypyridin-2-yl, 3-ethoxypyridin-2-yl, 3-difluoromethoxypyridin-2-yl, 5-methoxypyridin-2-yl, 5-ethoxypyridin-2-yl, 5-difluoromethoxypyridin-2-yl, 3-chloro-5-trifluoromethylpyridin-2-yl, 3-fluoro-5-trifluoromethylpyridin-2-yl, 3-bromo-5-trifluoromethylpyridin-2-yl, 3-methyl-5-trifluoromethylpyridin-2-yl, 3-ethyl-5-trifluoromethylpyridin-2-yl, 3-chloro-5-difluoromethoxypyridin-2-yl, 3-fluoro-5-difluoromethoxypyridin-2-yl, 3-methyl-5-difluoromethoxypyridin-2-yl, 3-chloro-5-trichloromethylpyridin-2-yl, 3-fluoro-5-trichloromethylpyridin-2-yl, 3-chloro-5-cyanopyridin-2-yl, 3-fluoro-5-cyanopyridin-2-yl, 3-methyl-5-cyanopyridin-2-yl, 3-ethyl-5-cyanopyridin-2-yl, 3-chloro-5-nitropyridin-2-yl, 3-chloro-5-methoxycarbonylpyridin-2-yl, 3-chloro-5-aminocarbonylpyridin-2-yl, 3-chloro-5-methylaminocarbonylpyridin-2-yl, 3-fluoro-5-nitropyridin-2-yl, 3,5-dichloropyridin-2-yl, 3,5-difluoropyridin-2-yl, 3,5-dibromopyridin-2-yl, 3-methyl-5-chloropyridin-2-yl, 3-methyl-5-fluoropyridin-2-yl, 3-methyl-5-bromopyridin-2-yl, 3-methoxy-5-trifluoromethylpyridin-2-yl, 3-methoxy-5-cyanopyridin-2-yl, 3-methoxy-5-nitropyridin-2-yl, 3-methoxy-5-difluoromethoxypyridin-2-yl, 3-ethoxy-5-trifluoromethylpyridin-2-yl, 3-ethoxy-5-cyanopyridin-2-yl, 3-ethoxy-5-nitropyridin-2-yl, 3-ethoxy-5-difluoromethoxypyridin-2-yl, 3-chloro-4-methyl-5-trifluoromethylpyridin-2-yl and 3,4-dichloro-5-trifluoromethylpyridin-2-yl. 
     In a further embodiment, Het is pyridin-3-yl, which is unsubstituted or carries 1 or 2 radicals R c . In a more preferred embodiment, Het is selected from 6-trifluoromethylpyridin-3-yl, 2-trifluoromethylpyridin-3-yl, 4-trifluoromethylpyridin-3-yl, 4-chloro-6-trifluoromethylpyridin-3-yl, 2-chloro-6-trifluoromethylpyridin-3-yl, 2-chloro-5-trifluoromethylpyridin-3-yl, 4-fluoro-6-trifluoromethylpyridin-3-yl, 4,6-di(trifluoromethyl)pyridin-3-yl, 4,6-dichloropyridin-3-yl, 4-methyl-6-chloropyridin-3-yl, 5-cyanopyridin-3-yl, 5-fluoro-6-cyanopyridin-3-yl, 4-fluoro-6-cyanopyridin-3-yl, 6-methylsulfonylpyridin-3-yl, 5-chloro-6-methylsulfonylpyridin-3-yl and 5-methyl-6-methylsulfonylpyridin-3-yl. 
     In a further embodiment, Het is a pyridazinyl radical. More preferably, Het is pyridazin-3-yl, which is unsubstituted or carries 1 or 2 radicals R c . In a particularly preferred embodiment, Het is selected from 4-trifluoromethylpyridazin-3-yl, 4-methyl-6-trifluoromethylpyridazin-3-yl, 4-chloro-6-difluoromethoxypyridazin-3-yl, 4-fluoro-6-difluoromethoxypyridazin-3-yl and 4-methyl-6-difluoromethoxypyridazin-3-yl. 
     In a further embodiment, Het is a pyrimidinyl radical and preferably selected from pyrimidin-2-yl, pyrimidin-4-yl and pyrimidin-5-yl, and wherein the aforementioned pyrimidinyl radicals are unsubstituted or carry 1, 2 or 3 identical or different substituents R c . In a particularly preferred embodiment, Het is selected from pyrimidin-2-yl, 4-trifluoromethylpyrimidin-2-yl, 5-trifluoromethylpyrimidin-2-yl, 2-trifluoromethylpyrimid in-4-yl, 2-trifluoromethylpyrimidin-5-yl, 6-trifluoromethylpyrimidin-4-yl, 4-cyanopyrimidin-2-yl, 5-cyanopyrimidin-2-yl, 4-(1,1,1-trifluoroethoxy)pyrimidin-2-yl, 5-chloro-6-trifluoromethylpyrimidin-4-yl, 5-fluoro-6-trifluoromethylpyrimidin-4-yl and 5-chloro-2-trifluoromethylpyrimidin-4-yl. 
     Another embodiment of the invention relates to compounds I, wherein Het is a 5-membered heteroaryl, wherein the ring member atoms of the heteroaryl include besides carbon atoms 1, 2, 3 or 4 heteroatoms selected from the group of N, O and S, and wherein the heteroaryl is unsubstituted or carries 1, 2, 3 or 4 identical or different groups R c . 
     If Het is a 5-membered heteroaryl, in one embodiment of the invention, Het carries one nitrogen as ring member atom. 
     If Het is a 5-membered heteroaryl, Het carries one heteroatom as ring member atom. In one embodiment, Het is a furanyl radical selected from furan-2-yl and furan-3-yl, wherein the aforementioned furanyl radicals are unsubstituted or carry 1, 2 or 3 identical or different substituents R c . In another embodiment, Het is a thienyl radical selected from thien-2-yl and thien-3-yl, wherein the aforementioned thienyl radicals are unsubstituted or carry 1, 2 or 3 identical or different substituents R c . In a further embodiment, Het is a pyrrolyl radical selected from pyrrol-2-yl and pyrrol-3-yl, wherein the aforementioned pyrrolyl radicals are unsubstituted or carry 1, 2, 3 or 4 identical or different substituents R c . 
     If Het is a 5-membered heteroaryl, Het carries two heteroatoms as ring member atoms. In a more preferred embodiment, Het carries at least one nitrogen as ring member atom. In another embodiment, Het is a pyrazolyl radical that is unsubstituted or carries 1, 2 or 3 identical or different substituents R c . In a further embodiment, Het is an isoxazolyl radical that is unsubstituted or carries 1 or 2 identical or different substituents R c . In a further embodiment, Het is an isothiazolyl radical that is unsubstituted or carries 1 or 2 identical or different substituents R c . In a further embodiment, Het is an imidazolyl radical that is unsubstituted or carries 1, 2 or 3 identical or different substituents R c . In a further embodiment, Het is an oxazolyl radical that is unsubstituted or carries 1 or 2 identical or different substituents R c . In a further embodiment, Het is a thiazolyl radical that is unsubstituted or carries 1 or 2 identical or different substituents R c . More preferably, Het is thiazol-2-yl, which is unsubstituted or carries 1 or 2 radicals R c . In a particularly preferred embodiment, Het is selected from thiazol-2-yl, 5-trifluoromethylthiazol-2-yl and 4-trifluoromethylthiazol-2-yl. 
     Particularly preferred embodiments of the invention relate to compounds I, in which Het is one of the following radicals H-1 to H-12: 
                                             No.   Het                          H-1                                             H-2                                             H-3                                             H-4                                             H-5                                             H-6                                             H-7                                             H-8                                             H-9                                             H-10                                             H-11                                             H-12                                              
in which * indicates the bond to A; and R c1 , R c2 , R c3  and R c4  and are each independently hydrogen or have one of the definitions specified for R c , especially those being preferred.
 
     One embodiment of the invention relates to compounds I, wherein Het carries 1, 2 or 3 radicals R c , preferably Het carries 1 or 2 radicals R c , in particular Het carries 1 radical R c . A further embodiment relates to compounds I, wherein Het carries 2 radicals R c . A further embodiment relates to compounds I, wherein Het carries 3 radicals R c . A further embodiment relates to compounds I, wherein Het is unsubstituted. In a further embodiment, two radicals R c  that are bound to adjacent ring member atoms of the group Het do not form together with said ring member atoms any fused cycle. 
     Preferably, R c  is halogen, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C(═O)R′, C(═NOR″)R′″, C 3 -C 8 -cycloalkyl, C 1 -C 6 -alkyl-C 3 -C 8 -cycloalkyl, phenyl, phenoxy, phenoxy-C 1 -C 4 -alkyl or a 5- or 6-membered heteroaryl, wherein the ring member atoms of the heteroaryl include besides carbon atoms 1, 2, 3 or 4 heteroatoms selected from the group of N, O and S, and wherein the aforementioned cyclic radicals are unsubstituted or carry 1, 2, 3 or 4 identical or different substituents R d . 
     In one embodiment, R c  is halogen and preferably selected from F and Cland in particular, R c  is Cl. In another embodiment, R c  is CN. In a further embodiment, R c  is C 1 -C 6 -alkyl and preferably selected from methyl, ethyl, n-propyl and i-propyl, and in particular, R c  is methyl. In a further embodiment, R c  is C 1 -C 6 -haloalkyl. More preferably, R c  is C 1 -haloalkyl and selected from fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl and trichloromethyl, and in particular, R c  is trifluoromethyl. In a further embodiment, R c  is C 1 -C 6 -alkoxy and preferably selected from methoxy and ethoxy. In a further embodiment, R c  is C 1 -C 6 -haloalkoxy and preferably halomethoxy such as difluormethoxy, trifluormethoxy, dichlormethoxy and trichlormethoxy; haloethoxy such as 2,2-difluorethoxy, 2,2,2-trifluorethoxy, 2,2-dichlorethoxy and 2,2,2-trichloroethoxy; halo-n-propoxy, halo-i-propoxy, halo-n-butoxy, halo-1-methyl-propoxy, halo-2-methyl-propoxy or halo-1,1-dimethylethoxy. In a further embodiment, R c  is C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl and preferably selected from methoxymethyl, ethoxymethyl, methoxyethyl and ethoxyethyl. 
     In a further embodiment, R c  is C 3 -C 8 -cycloalkyl and preferably selected from cyclopropyl, cyclopentyl and cyclohexyl, and in particular, R c  is cyclopropyl. In a further embodiment, R c  is C 1 -C 6 -alkyl-C 3 -C 8 -cycloalkyl and selected from cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, cycloheptylmethyl and cyclooctylmethyl. In a further embodiment, R c  is phenyl. In a further embodiment, R c  is phenoxy. In a further embodiment, R c  is phenoxy-C 1 -C 6 -alkyl and selected from phenoxymethyl, 1-phenoxy-ethyl and 2-phenoxyethyl. 
     In a further embodiment, R c  is a 6-membered heteroaryl, wherein the ring member atoms of the heteroaryl include besides carbon atoms 1, 2 or 3 nitrogen atoms, and wherein R c  is unsubstituted or carries 1, 2, 3 or 4 identical or different groups R d . 
     If R c  is a 5-membered heteroaryl, R c  carries 1 heteroatom as ring member atom. In another embodiment, R c  is a furanyl radical that is unsubstituted or carries 1, 2 or 3 identical or different substituents R d . In a further embodiment, R c  is a thienyl radical that is unsubstituted or carries 1, 2 or 3 identical or different substituents R d . In a further embodiment, R c  is a pyrrolyl radical selected from pyrrol-2-yl and pyrrol-3-yl, wherein the aforementioned pyrrolyl radicals are unsubstituted or carry 1, 2, 3 or 4 identical or different substituents R d . 
     If R c  is a 5-membered heteroaryl, R c  carries 2 heteroatoms as ring member atoms. In a further embodiment, R c  is a pyrazolyl radical selected from pyrazol-3-yl, pyrazol-4-yl and pyrazol-5-yl, wherein the aforementioned pyrazolyl radicals are unsubstituted or carry 1, 2 or 3 identical or different substituents R d . In a further embodiment, R c  is an isoxazolyl radical that is unsubstituted or carries 1 or 2 identical or different substituents R d . In a further embodiment, R c  is an isothiazolyl radical that is unsubstituted or carries 1 or 2 identical or different substituents R d . In a further embodiment, R c  is an imidazolyl radical that is unsubstituted or carries 1, 2 or 3 identical or different substituents R d . In a further embodiment, R c  is an oxazolyl radical that is unsubstituted or carries 1 or 2 identical or different substituents R d . In a further embodiment, R c  is a thiazolyl radical that is unsubstituted or carries 1 or 2 identical or different substituents R d . 
     If R c  is a 5-membered heteroaryl, in another embodiment, R c  carries 3 heteroatoms as ring member atoms. 
     A further embodiment relates to compounds I, wherein two radicals R c  that are bound to adjacent ring member atoms of the group Het form together with said ring member atoms a fused cycle being a fused 5-, 6- or 7-membered saturated, partially unsaturated or aromatic carbocycle or heterocycle, wherein the ring member atoms of the fused heterocycle include besides carbon atoms 1, 2, 3 or 4 heteroatoms selected from the group of N, O and S, and wherein the fused cycle is unsubstituted and carries 1, 2, 3 or 4 identical or different R c  radicals. In one embodiment, the fused cycle is preferably phenyl. In another embodiment, the fused cycle is preferably a saturated carbocycle and in particular cyclohexyl. In a further embodiment, the fused cycle is preferably a partially unsaturated carbocycle and in particular cyclohexenyl. 
     In a further embodiment, two radicals R c  that are bound to adjacent ring member atoms of the group Het form together with said ring member atoms a fused 5-, 6- or 7-membered saturated, partially unsaturated or aromatic cycle, wherein the fused cycle is substituted by 1, 2, 3 or 4 R e  radicals, and preferably, by 1, 2 or 3 R e  radicals, more preferably by 1 or 2 R e  radicals, and in particular by 1 radical R e . In one embodiment, R e  is halogen and preferably selected from fluorine and chlorine and in particular, chlorine. In another embodiment, R e  is CN. In a further embodiment, R e  is C 1 -C 4 -alkyl and in particular, methyl. In a further embodiment, R e  is C 1 -C 4 -alkoxy and preferably selected from methoxy and ethoxy. 
     If R c  is C(═O)R′, R′ is selected from NH 2 , C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkoxy-C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 1 -C 4 -alkylamino and di(C 1 -C 4 -alkyl)-amino. If R c  is C(═O)R′, R′ is preferably NH 2 . If R c  is C(═O)R′, R′ is preferably C 1 -C 4 -alkyl and in particular, methyl. If R c  is C(═O)R′, R′ is preferably C 1 -C 4 -alkoxy and more preferably selected from methoxy and ethoxy. If R c  is C(═O)R′, R′ is preferably C 1 -C 4 -haloalkyl. More preferably, R′ is C 1 -haloalkyl and selected from fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl and trichloromethyl. If R c  is C(═O)R′, R′ is preferably C 1 -C 4 -haloalkoxy and preferably halomethoxy, such as difluoromethoxy, trifluoromethoxy, dichloromethoxy and trichloromethoxy, or haloethoxy, such as 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, 2,2-dichloroethoxy and 2,2,2-trichloroethoxy. If R c  is C(═O)R′, R′ is preferably C 1 -C 4 -alkoxy-C 1 -C 4 -alkoxy and selected from methoxy-methoxy, methoxy-ethoxy, ethoxy-methoxy and ethoxy-ethoxy. If R c  is C(═O)R′, R′ is preferably C 1 -C 4 -alkylamino and in particular selected from methylamino and ethylamino. If R c  is C(═O)R′, R′ is preferably di(C 1 -C 4 -alkyl)amino and more preferably selected from dimethylamino, methyl-ethyl-amino, methyl-n-propyl-amino, methyl-i-propyl-amino, methyl-n-butyl-amino, methyl-(1-methyl-propyl)-amino, methyl-(2-methylpropyl)-amino, methyl-(1,1-dimethylethyl)-amino, diethylamino, and in particular from dimethylamino, methyl-ethylamino and diethylamino. 
     If R c  is C(═NOR″)R′″, in one embodiment, R″ is C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -alkynyl or C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl. 
     If R c  is C(═NOR″)R′″, R″ is preferably C 1 -C 4 -alkyl and more preferably selected from methyl, ethyl, n-propyl, i-propyl, and in particular, R″ is methyl. If R c  is C(═NOR″)R′″, R″ is preferably C 2 -C 4 -alkenyl and selected from vinyl, prop-1-en-3-yl, but-1-en-3-yl, but-1-en-4-yl and but-2-en-1-yl. If R c  is C(═NOR″)R′″, R″ is preferably C 2 -C 4 -alkynyl and selected from prop-1-in-3-yl, but-1-in-3-yl, but-1-in-4-yl and but-2-in-1-yl. If R c  is C(═NOR″)R′″, R″ is preferably C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl and more preferably selected from methoxymethyl, ethoxymethyl, methoxyethyl and ethoxyethyl. 
     If R c  is C(═NOR″)R′″, R′″ is C 1 -C 4 -alkyl and preferably selected from methyl, ethyl, n-propyl, i-propyl, and in particular, R′″ is methyl. If R c  is C(═NOR″)R′″, in another embodiment, R′″ is hydrogen. 
     If R c  is present, one embodiment relates to compounds I, wherein R c  carries 1, 2, 3 or 4 radicals R d , preferably 1, 2 or 3 radicals R d , and more preferably 1 or 2 radicals R d . In another embodiment, R c  carries one radical R d . 
     In one embodiment, R d  is halogen and preferably selected from F and Cl, and in particular, Cl. In another embodiment, R d  is CN. In a further embodiment, R d  is C 1 -C 4 -alkyl and preferably selected from methyl, ethyl, n-propyl and i-propyl and in particular, R d  is methyl. In a further embodiment, R d  is C 1 -C 4 -haloalkyl. More preferably, R d  is C 1 -haloalkyl and selected from fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl and trichloromethyl, and in particular, R d  is trifluoromethyl. 
     A skilled person will readily understand that the preferences given in connection with compounds I apply for formulae I.1 and I.2 as defined above. 
     With respect to their use, particular preference is given to the compounds of formula 1.2 compiled in the tables 1 to 60 below, wherein the definitions for the substituents R a  of the pyridine group are selected from P-1 to P-20 in Table P and wherein the definitions for group A are selected from A-1 to A-3 as described above and wherein the definitions for group Het are selected from H-1 to H-12 as described above. Here, the groups mentioned in the Tables for a substituent are furthermore, independently of the combination wherein they are mentioned, a particularly preferred embodiment of the substituent in question. 
     Table 1: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in line P-1 of table P, A is A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
Table 2: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in line P-2 of table P, A is A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
Table 3: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in line P-3 of table P, A is A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
Table 4: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in line P-4 of table P, A is A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
Table 5: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in line P-5 of table P, A is A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
Table 6: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in line P-6 of table P, A is A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
Table 7: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in line P-7 of table P, A is A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
Table 8: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in line P-8 of table P, A is A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
Table 9: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in line P-9 of table P, A is A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
Table 10: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in line P-10 of table P, A is A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
Table 11: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in line P-11 of table P, A is A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
Table 12: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in line P-12 of table P, A is A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
Table 13: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in line P-13 of table P, A is A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
Table 14: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in line P-14 of table P, A is A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
Tables 15 to 28: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in Tables 1 to 14, A is A-2 instead of A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
Tables 29 to 42: Compounds of formula I.2, wherein R a1 , R a2 , R a3  and R a4  are defined as in Tables 1 to 14, A is A-3 instead of A-1 and the meaning of Het for each compound corresponds to one line of table A.
 
                                         TABLE A               line   Het   R c1     R c2     R c3     R c4                                                          1   H-1   H   H   H   H       2   H-1   F   H   H   H       3   H-1   Cl   H   H   H       4   H-1   CH 3     H   H   H       5   H-1   CF 3     H   H   H       6   H-1   CN   H   H   H       7   H-1   OCH 3     H   H   H       8   H-1   OC 2 H 5     H   H   H       9   H-1   OCF 3     H   H   H       10   H-1   H   F   H   H       11   H-1   H   Cl   H   H       12   H-1   H   CH 3     H   H       13   H-1   H   CF 3     H   H       14   H-1   H   CN   H   H       15   H-1   H   OCH 3     H   H       16   H-1   H   OC 2 H 5     H   H       17   H-1   H   OCF 3     H   H       18   H-1   H   H   F   H       19   H-1   H   H   Cl   H       20   H-1   H   H   CH 3     H       21   H-1   H   H   CF 3     H       22   H-1   H   H   CN   H       23   H-1   H   H   OCH 3     H       24   H-1   H   H   OC 2 H 5     H       25   H-1   H   H   OCF 3     H       26   H-1   H   H   H   F       27   H-1   H   H   H   Cl       28   H-1   H   H   H   CH 3         29   H-1   H   H   H   CF 3         30   H-1   H   H   H   CN       31   H-1   H   H   H   OCH 3         32   H-1   H   H   H   OC 2 H 5         33   H-1   H   H   H   OCF 3         34   H-1   F   F   H   H       35   H-1   Cl   F   H   H       36   H-1   CH 3     F   H   H       37   H-1   CF 3     F   H   H       38   H-1   CN   F   H   H       39   H-1   OCH 3     F   H   H       40   H-1   OC 2 H 5     F   H   H       41   H-1   OCF 3     F   H   H       42   H-1   F   Cl   H   H       43   H-1   Cl   Cl   H   H       44   H-1   CH 3     Cl   H   H       45   H-1   CF 3     Cl   H   H       46   H-1   CN   Cl   H   H       47   H-1   OCH 3     Cl   H   H       48   H-1   OC 2 H 5     Cl   H   H       49   H-1   OCF 3     Cl   H   H       50   H-1   F   CH 3     H   H       51   H-1   Cl   CH 3     H   H       52   H-1   CH 3     CH 3     H   H       53   H-1   CF 3     CH 3     H   H       54   H-1   CN   CH 3     H   H       55   H-1   OCH 3     CH 3     H   H       56   H-1   OC 2 H 5     CH 3     H   H       57   H-1   OCF 3     CH 3     H   H       58   H-1   F   CF 3     H   H       59   H-1   Cl   CF 3     H   H       60   H-1   CH 3     CF 3     H   H       61   H-1   CF 3     CF 3     H   H       62   H-1   CN   CF 3     H   H       63   H-1   OCH 3     CF 3     H   H       64   H-1   OC 2 H 5     CF 3     H   H       65   H-1   OCF 3     CF 3     H   H       66   H-1   F   CN   H   H       67   H-1   Cl   CN   H   H       68   H-1   CH 3     CN   H   H       69   H-1   CF 3     CN   H   H       70   H-1   CN   CN   H   H       71   H-1   OCH 3     CN   H   H       72   H-1   OC 2 H 5     CN   H   H       73   H-1   OCF 3     CN   H   H       74   H-1   F   OCH 3     H   H       75   H-1   Cl   OCH 3     H   H       76   H-1   CH 3     OCH 3     H   H       77   H-1   CF 3     OCH 3     H   H       78   H-1   CN   OCH 3     H   H       79   H-1   OCH 3     OCH 3     H   H       80   H-1   OC 2 H 5     OCH 3     H   H       81   H-1   OCF 3     OCH 3     H   H       82   H-1   F   OC 2 H 5     H   H       83   H-1   Cl   OC 2 H 5     H   H       84   H-1   CH 3     OC 2 H 5     H   H       85   H-1   CF 3     OC 2 H 5     H   H       86   H-1   CN   OC 2 H 5     H   H       87   H-1   OCH 3     OC 2 H 5     H   H       88   H-1   OC 2 H 5     OC 2 H 5     H   H       89   H-1   OCF 3     OC 2 H 5     H   H       90   H-1   F   OCF 3     H   H       91   H-1   Cl   OCF 3     H   H       92   H-1   CH 3     OCF 3     H   H       93   H-1   CF 3     OCF 3     H   H       94   H-1   CN   OCF 3     H   H       95   H-1   OCH 3     OCF 3     H   H       96   H-1   OC 2 H 5     OCF 3     H   H       97   H-1   OCF 3     OCF 3     H   H       98   H-1   F   H   F   H       99   H-1   Cl   H   F   H       100   H-1   CH 3     H   F   H       101   H-1   CF 3     H   F   H       102   H-1   CN   H   F   H       103   H-1   OCH 3     H   F   H       104   H-1   OC 2 H 5     H   F   H       105   H-1   OCF 3     H   F   H       106   H-1   F   H   Cl   H       107   H-1   Cl   H   Cl   H       108   H-1   CH 3     H   Cl   H       109   H-1   CF 3     H   Cl   H       110   H-1   CN   H   Cl   H       111   H-1   OCH 3     H   Cl   H       112   H-1   OC 2 H 5     H   Cl   H       113   H-1   OCF 3     H   Cl   H       114   H-1   F   H   CH 3     H       115   H-1   Cl   H   CH 3     H       116   H-1   CH 3     H   CH 3     H       117   H-1   CF 3     H   CH 3     H       118   H-1   CN   H   CH 3     H       119   H-1   OCH 3     H   CH 3     H       120   H-1   OC 2 H 5     H   CH 3     H       121   H-1   OCF 3     H   CH 3     H       122   H-1   F   H   CF 3     H       123   H-1   Cl   H   CF 3     H       124   H-1   CH 3     H   CF 3     H       125   H-1   CF 3     H   CF 3     H       126   H-1   CN   H   CF 3     H       127   H-1   OCH 3     H   CF 3     H       128   H-1   OC 2 H 5     H   CF 3     H       129   H-1   OCF 3     H   CF 3     H       130   H-1   F   H   CN   H       131   H-1   Cl   H   CN   H       132   H-1   CH 3     H   CN   H       133   H-1   CF 3     H   CN   H       134   H-1   CN   H   CN   H       135   H-1   OCH 3     H   CN   H       136   H-1   OC 2 H 5     H   CN   H       137   H-1   OCF 3     H   CN   H       138   H-1   OCHF 2     H   CN   H       139   H-1   F   H   OCH 3     H       140   H-1   Cl   H   OCH 3     H       141   H-1   CH 3     H   OCH 3     H       142   H-1   CF 3     H   OCH 3     H       143   H-1   CN   H   OCH 3     H       144   H-1   OCH 3     H   OCH 3     H       145   H-1   OC 2 H 5     H   OCH 3     H       146   H-1   OCF 3     H   OCH 3     H       147   H-1   F   H   OC 2 H 5     H       148   H-1   Cl   H   OC 2 H 5     H       149   H-1   CH 3     H   OC 2 H 5     H       150   H-1   CF 3     H   OC 2 H 5     H       151   H-1   CN   H   OC 2 H 5     H       152   H-1   OCH 3     H   OC 2 H 5     H       153   H-1   OC 2 H 5     H   OC 2 H 5     H       154   H-1   OCF 3     H   OC 2 H 5     H       155   H-1   F   H   OCF 3     H       156   H-1   Cl   H   OCF 3     H       157   H-1   CH 3     H   OCF 3     H       158   H-1   CF 3     H   OCF 3     H       159   H-1   CN   H   OCF 3     H       160   H-1   OCH 3     H   OCF 3     H       161   H-1   OC 2 H 5     H   OCF 3     H       162   H-1   OCF 3     H   OCF 3     H       163   H-1   F   H   H   F       164   H-1   Cl   H   H   F       165   H-1   CH 3     H   H   F       166   H-1   CF 3     H   H   F       167   H-1   CN   H   H   F       168   H-1   OCH 3     H   H   F       169   H-1   OC 2 H 5     H   H   F       170   H-1   OCF 3     H   H   F       171   H-1   F   H   H   Cl       172   H-1   Cl   H   H   Cl       173   H-1   CH 3     H   H   Cl       174   H-1   CF 3     H   H   Cl       175   H-1   CN   H   H   Cl       176   H-1   OCH 3     H   H   Cl       177   H-1   OC 2 H 5     H   H   Cl       178   H-1   OCF 3     H   H   Cl       179   H-1   F   H   H   CH 3         180   H-1   Cl   H   H   CH 3         181   H-1   CH 3     H   H   CH 3         182   H-1   CF 3     H   H   CH 3         183   H-1   CN   H   H   CH 3         184   H-1   OCH 3     H   H   CH 3         185   H-1   OC 2 H 5     H   H   CH 3         186   H-1   OCF 3     H   H   CH 3         187   H-1   F   H   H   CF 3         188   H-1   Cl   H   H   CF 3         189   H-1   CH 3     H   H   CF 3         190   H-1   CF 3     H   H   CF 3         191   H-1   CN   H   H   CF 3         192   H-1   OCH 3     H   H   CF 3         193   H-1   OC 2 H 5     H   H   CF 3         194   H-1   OCF 3     H   H   CF 3         195   H-1   F   H   H   CN       196   H-1   Cl   H   H   CN       197   H-1   CH 3     H   H   CN       198   H-1   CF 3     H   H   CN       199   H-1   CN   H   H   CN       200   H-1   OCH 3     H   H   CN       201   H-1   OC 2 H 5     H   H   CN       202   H-1   OCF 3     H   H   CN       203   H-1   F   H   H   OCH 3         204   H-1   Cl   H   H   OCH 3         205   H-1   CH 3     H   H   OCH 3         206   H-1   CF 3     H   H   OCH 3         207   H-1   CN   H   H   OCH 3         208   H-1   OCH 3     H   H   OCH 3         209   H-1   OC 2 H 5     H   H   OCH 3         210   H-1   OCF 3     H   H   OCH 3         211   H-1   F   H   H   OC 2 H 5         212   H-1   Cl   H   H   OC 2 H 5         213   H-1   CH 3     H   H   OC 2 H 5         214   H-1   CF 3     H   H   OC 2 H 5         215   H-1   CN   H   H   OC 2 H 5         216   H-1   OCH 3     H   H   OC 2 H 5         217   H-1   OC 2 H 5     H   H   OC 2 H 5         218   H-1   OCF 3     H   H   OC 2 H 5         219   H-1   F   H   H   OCF 3         220   H-1   Cl   H   H   OCF 3         221   H-1   CH 3     H   H   OCF 3         222   H-1   CF 3     H   H   OCF 3         223   H-1   CN   H   H   OCF 3         224   H-1   OCH 3     H   H   OCF 3         225   H-1   OC 2 H 5     H   H   OCF 3         226   H-1   OCF 3     H   H   OCF 3         227   H-1   H   F   F   H       228   H-1   H   Cl   F   H       229   H-1   H   CH 3     F   H       230   H-1   H   CF 3     F   H       231   H-1   H   CN   F   H       232   H-1   H   OCH 3     F   H       233   H-1   H   OC 2 H 5     F   H       234   H-1   H   OCF 3     F   H       235   H-1   H   F   Cl   H       236   H-1   H   Cl   Cl   H       237   H-1   H   CH 3     Cl   H       238   H-1   H   CF 3     Cl   H       239   H-1   H   CN   Cl   H       240   H-1   H   OCH 3     Cl   H       241   H-1   H   OC 2 H 5     Cl   H       242   H-1   H   OCF 3     Cl   H       243   H-1   H   F   CH 3     H       244   H-1   H   Cl   CH 3     H       245   H-1   H   CH 3     CH 3     H       246   H-1   H   CF 3     CH 3     H       247   H-1   H   CN   CH 3     H       248   H-1   H   OCH 3     CH 3     H       249   H-1   H   OC 2 H 5     CH 3     H       250   H-1   H   OCF 3     CH 3     H       251   H-1   H   F   CF 3     H       252   H-1   H   Cl   CF 3     H       253   H-1   H   CH 3     CF 3     H       254   H-1   H   CF 3     CF 3     H       255   H-1   H   CN   CF 3     H       256   H-1   H   OCH 3     CF 3     H       257   H-1   H   OC 2 H 5     CF 3     H       258   H-1   H   OCF 3     CF 3     H       259   H-1   H   F   CN   H       260   H-1   H   Cl   CN   H       261   H-1   H   CH 3     CN   H       262   H-1   H   CF 3     CN   H       263   H-1   H   CN   CN   H       264   H-1   H   OCH 3     CN   H       265   H-1   H   OC 2 H 5     CN   H       266   H-1   H   OCF 3     CN   H       267   H-1   H   F   OCH 3     H       268   H-1   H   Cl   OCH 3     H       269   H-1   H   CH 3     OCH 3     H       270   H-1   H   CF 3     OCH 3     H       271   H-1   H   CN   OCH 3     H       272   H-1   H   OCH 3     OCH 3     H       273   H-1   H   OC 2 H 5     OCH 3     H       274   H-1   H   OCF 3     OCH 3     H       275   H-1   H   F   OC 2 H 5     H       276   H-1   H   Cl   OC 2 H 5     H       277   H-1   H   CH 3     OC 2 H 5     H       278   H-1   H   CF 3     OC 2 H 5     H       279   H-1   H   CN   OC 2 H 5     H       280   H-1   H   OCH 3     OC 2 H 5     H       281   H-1   H   OC 2 H 5     OC 2 H 5     H       282   H-1   H   OCF 3     OC 2 H 5     H       283   H-1   H   F   OCF 3     H       284   H-1   H   Cl   OCF 3     H       285   H-1   H   CH 3     OCF 3     H       286   H-1   H   CF 3     OCF 3     H       287   H-1   H   CN   OCF 3     H       288   H-1   H   OCH 3     OCF 3     H       289   H-1   H   OC 2 H 5     OCF 3     H       290   H-1   H   OCF 3     OCF 3     H       291   H-1   H   F   H   F       292   H-1   H   Cl   H   F       293   H-1   H   Br   H   F       294   H-1   H   CH 3     H   F       295   H-1   H   CF 3     H   F       296   H-1   H   CN   H   F       297   H-1   H   OCH 3     H   F       298   H-1   H   OC 2 H 5     H   F       299   H-1   H   OCF 3     H   F       300   H-1   H   OCHF 2     H   F       301   H-1   H   F   H   Cl       302   H-1   H   Cl   H   Cl       303   H-1   H   CH 3     H   Cl       304   H-1   H   CF 3     H   Cl       305   H-1   H   CN   H   Cl       306   H-1   H   OCH 3     H   Cl       307   H-1   H   OC 2 H 5     H   Cl       308   H-1   H   OCF 3     H   Cl       309   H-1   H   F   H   CH 3         310   H-1   H   Cl   H   CH 3         311   H-1   H   CH 3     H   CH 3         312   H-1   H   CF 3     H   CH 3         313   H-1   H   CN   H   CH 3         314   H-1   H   OCH 3     H   CH 3         315   H-1   H   OC 2 H 5     H   CH 3         316   H-1   H   OCF 3     H   CH 3         317   H-1   H   F   H   CF 3         318   H-1   H   Cl   H   CF 3         319   H-1   H   CH 3     H   CF 3         320   H-1   H   CF 3     H   CF 3         321   H-1   H   CN   H   CF 3         322   H-1   H   OCH 3     H   CF 3         323   H-1   H   OC 2 H 5     H   CF 3         324   H-1   H   OCF 3     H   CF 3         325   H-1   H   F   H   CN       326   H-1   H   Cl   H   CN       327   H-1   H   CH 3     H   CN       328   H-1   H   CF 3     H   CN       329   H-1   H   CN   H   CN       330   H-1   H   OCH 3     H   CN       331   H-1   H   OC 2 H 5     H   CN       332   H-1   H   OCF 3     H   CN       333   H-1   H   F   H   OCH 3         334   H-1   H   Cl   H   OCH 3         335   H-1   H   CH 3     H   OCH 3         336   H-1   H   CF 3     H   OCH 3         337   H-1   H   CN   H   OCH 3         338   H-1   H   OCH 3     H   OCH 3         339   H-1   H   OC 2 H 5     H   OCH 3         340   H-1   H   OCF 3     H   OCH 3         341   H-1   H   F   H   OC 2 H 5         342   H-1   H   Cl   H   OC 2 H 5         343   H-1   H   CH 3     H   OC 2 H 5         344   H-1   H   CF 3     H   OC 2 H 5         345   H-1   H   CN   H   OC 2 H 5         346   H-1   H   OCH 3     H   OC 2 H 5         347   H-1   H   OC 2 H 5     H   OC 2 H 5         348   H-1   H   OCF 3     H   OC 2 H 5         349   H-1   H   F   H   OCF 3         350   H-1   H   Cl   H   OCF 3         351   H-1   H   CH 3     H   OCF 3         352   H-1   H   CF 3     H   OCF 3         353   H-1   H   CN   H   OCF 3         354   H-1   H   OCH 3     H   OCF 3         355   H-1   H   OC 2 H 5     H   OCF 3         356   H-1   H   OCF 3     H   OCF 3         357   H-1   H   H   F   F       358   H-1   H   H   Cl   F       359   H-1   H   H   CH 3     F       360   H-1   H   H   CF 3     F       361   H-1   H   H   CN   F       362   H-1   H   H   OCH 3     F       363   H-1   H   H   OC 2 H 5     F       364   H-1   H   H   OCF 3     F       365   H-1   H   H   F   Cl       366   H-1   H   H   Cl   Cl       367   H-1   H   H   CH 3     Cl       368   H-1   H   H   CF 3     Cl       369   H-1   H   H   CN   Cl       370   H-1   H   H   OCH 3     Cl       371   H-1   H   H   OC 2 H 5     Cl       372   H-1   H   H   OCF 3     Cl       373   H-1   H   H   F   CH 3         374   H-1   H   H   Cl   CH 3         375   H-1   H   H   CH 3     CH 3         376   H-1   H   H   CF 3     CH 3         377   H-1   H   H   CN   CH 3         378   H-1   H   H   OCH 3     CH 3         379   H-1   H   H   OC 2 H 5     CH 3         380   H-1   H   H   OCF 3     CH 3         381   H-1   H   H   F   CF 3         382   H-1   H   H   Cl   CF 3         383   H-1   H   H   CH 3     CF 3         384   H-1   H   H   CF 3     CF 3         385   H-1   H   H   CN   CF 3         386   H-1   H   H   OCH 3     CF 3         387   H-1   H   H   OC 2 H 5     CF 3         388   H-1   H   H   OCF 3     CF 3         389   H-1   H   H   F   CN       390   H-1   H   H   Cl   CN       391   H-1   H   H   CH 3     CN       392   H-1   H   H   CF 3     CN       393   H-1   H   H   CN   CN       394   H-1   H   H   OCH 3     CN       395   H-1   H   H   OC 2 H 5     CN       396   H-1   H   H   OCF 3     CN       397   H-1   H   H   F   OCH 3         398   H-1   H   H   Cl   OCH 3         399   H-1   H   H   CH 3     OCH 3         400   H-1   H   H   CF 3     OCH 3         401   H-1   H   H   CN   OCH 3         402   H-1   H   H   OCH 3     OCH 3         403   H-1   H   H   OC 2 H 5     OCH 3         404   H-1   H   H   OCF 3     OCH 3         405   H-1   H   H   F   OC 2 H 5         406   H-1   H   H   Cl   OC 2 H 5         407   H-1   H   H   CH 3     OC 2 H 5         408   H-1   H   H   CF 3     OC 2 H 5         409   H-1   H   H   CN   OC 2 H 5         410   H-1   H   H   OCH 3     OC 2 H 5         411   H-1   H   H   OC 2 H 5     OC 2 H 5         412   H-1   H   H   OCF 3     OC 2 H 5         413   H-1   H   H   F   OCF 3         414   H-1   H   H   Cl   OCF 3         415   H-1   H   H   CH 3     OCF 3         416   H-1   H   H   CF 3     OCF 3         417   H-1   H   H   CN   OCF 3         418   H-1   H   H   OCH 3     OCF 3         419   H-1   H   H   OC 2 H 5     OCF 3         420   H-1   H   H   OCF 3     OCF 3         421   H-2   H   H   H   H       422   H-2   F   H   H   H       423   H-2   Cl   H   H   H       424   H-2   CH 3     H   H   H       425   H-2   CF 3     H   H   H       426   H-2   CN   H   H   H       427   H-2   OCH 3     H   H   H       428   H-2   OC 2 H 5     H   H   H       429   H-2   OCF 3     H   H   H       430   H-2   H   F   H   H       431   H-2   H   Cl   H   H       432   H-2   H   CH 3     H   H       433   H-2   H   CF 3     H   H       434   H-2   H   CN   H   H       435   H-2   H   OCH 3     H   H       436   H-2   H   OC 2 H 5     H   H       437   H-2   H   OCF 3     H   H       438   H-2   H   H   F   H       439   H-2   H   H   Cl   H       440   H-2   H   H   CH 3     H       441   H-2   H   H   CF 3     H       442   H-2   H   H   CN   H       443   H-2   H   H   OCH 3     H       444   H-2   H   H   OC 2 H 5     H       445   H-2   H   H   OCF 3     H       446   H-2   H   H   H   F       447   H-2   H   H   H   Cl       448   H-2   H   H   H   CH 3         449   H-2   H   H   H   CF 3         450   H-2   H   H   H   CN       451   H-2   H   H   H   OCH 3         452   H-2   H   H   H   OC 2 H 5         453   H-2   H   H   H   OCF 3         454   H-2   F   F   H   H       455   H-2   Cl   F   H   H       456   H-2   CH 3     F   H   H       457   H-2   CF 3     F   H   H       458   H-2   CN   F   H   H       459   H-2   OCH 3     F   H   H       460   H-2   OC 2 H 5     F   H   H       461   H-2   OCF 3     F   H   H       462   H-2   F   Cl   H   H       463   H-2   Cl   Cl   H   H       464   H-2   CH 3     Cl   H   H       465   H-2   CF 3     Cl   H   H       466   H-2   CN   Cl   H   H       467   H-2   OCH 3     Cl   H   H       468   H-2   OC 2 H 5     Cl   H   H       469   H-2   OCF 3     Cl   H   H       470   H-2   F   CH 3     H   H       471   H-2   Cl   CH 3     H   H       472   H-2   CH 3     CH 3     H   H       473   H-2   CF 3     CH 3     H   H       474   H-2   CN   CH 3     H   H       475   H-2   OCH 3     CH 3     H   H       476   H-2   OC 2 H 5     CH 3     H   H       477   H-2   OCF 3     CH 3     H   H       478   H-2   F   CF 3     H   H       479   H-2   Cl   CF 3     H   H       480   H-2   CH 3     CF 3     H   H       481   H-2   CF 3     CF 3     H   H       482   H-2   CN   CF 3     H   H       483   H-2   OCH 3     CF 3     H   H       484   H-2   OC 2 H 5     CF 3     H   H       485   H-2   OCF 3     CF 3     H   H       486   H-2   F   CN   H   H       487   H-2   Cl   CN   H   H       488   H-2   CH 3     CN   H   H       489   H-2   CF 3     CN   H   H       490   H-2   CN   CN   H   H       491   H-2   OCH 3     CN   H   H       492   H-2   OC 2 H 5     CN   H   H       493   H-2   OCF 3     CN   H   H       494   H-2   F   OCH 3     H   H       495   H-2   Cl   OCH 3     H   H       496   H-2   CH 3     OCH 3     H   H       497   H-2   CF 3     OCH 3     H   H       498   H-2   CN   OCH 3     H   H       499   H-2   OCH 3     OCH 3     H   H       500   H-2   OC 2 H 5     OCH 3     H   H       501   H-2   OCF 3     OCH 3     H   H       502   H-2   F   OC 2 H 5     H   H       503   H-2   Cl   OC 2 H 5     H   H       504   H-2   CH 3     OC 2 H 5     H   H       505   H-2   CF 3     OC 2 H 5     H   H       506   H-2   CN   OC 2 H 5     H   H       507   H-2   OCH 3     OC 2 H 5     H   H       508   H-2   OC 2 H 5     OC 2 H 5     H   H       509   H-2   OCF 3     OC 2 H 5     H   H       510   H-2   F   OCF 3     H   H       511   H-2   Cl   OCF 3     H   H       512   H-2   CH 3     OCF 3     H   H       513   H-2   CF 3     OCF 3     H   H       514   H-2   CN   OCF 3     H   H       515   H-2   OCH 3     OCF 3     H   H       516   H-2   OC 2 H 5     OCF 3     H   H       517   H-2   OCF 3     OCF 3     H   H       518   H-2   F   H   F   H       519   H-2   Cl   H   F   H       520   H-2   CH 3     H   F   H       521   H-2   CF 3     H   F   H       522   H-2   CN   H   F   H       523   H-2   OCH 3     H   F   H       524   H-2   OC 2 H 5     H   F   H       525   H-2   OCF 3     H   F   H       526   H-2   F   H   Cl   H       527   H-2   Cl   H   Cl   H       528   H-2   CH 3     H   Cl   H       529   H-2   CF 3     H   Cl   H       530   H-2   CN   H   Cl   H       531   H-2   OCH 3     H   Cl   H       532   H-2   OC 2 H 5     H   Cl   H       533   H-2   OCF 3     H   Cl   H       534   H-2   F   H   CH 3     H       535   H-2   Cl   H   CH 3     H       536   H-2   CH 3     H   CH 3     H       537   H-2   CF 3     H   CH 3     H       538   H-2   CN   H   CH 3     H       539   H-2   OCH 3     H   CH 3     H       540   H-2   OC 2 H 5     H   CH 3     H       541   H-2   OCF 3     H   CH 3     H       542   H-2   F   H   CF 3     H       543   H-2   Cl   H   CF 3     H       544   H-2   CH 3     H   CF 3     H       545   H-2   CF 3     H   CF 3     H       546   H-2   CN   H   CF 3     H       547   H-2   OCH 3     H   CF 3     H       548   H-2   OC 2 H 5     H   CF 3     H       549   H-2   OCF 3     H   CF 3     H       550   H-2   F   H   CN   H       551   H-2   Cl   H   CN   H       552   H-2   CH 3     H   CN   H       553   H-2   CF 3     H   CN   H       554   H-2   CN   H   CN   H       555   H-2   OCH 3     H   CN   H       556   H-2   OC 2 H 5     H   CN   H       557   H-2   OCF 3     H   CN   H       558   H-2   OCHF 2     H   CN   H       559   H-2   F   H   OCH 3     H       560   H-2   Cl   H   OCH 3     H       561   H-2   CH 3     H   OCH 3     H       562   H-2   CF 3     H   OCH 3     H       563   H-2   CN   H   OCH 3     H       564   H-2   OCH 3     H   OCH 3     H       565   H-2   OC 2 H 5     H   OCH 3     H       566   H-2   OCF 3     H   OCH 3     H       567   H-2   F   H   OC 2 H 5     H       568   H-2   Cl   H   OC 2 H 5     H       569   H-2   CH 3     H   OC 2 H 5     H       570   H-2   CF 3     H   OC 2 H 5     H       571   H-2   CN   H   OC 2 H 5     H       572   H-2   OCH 3     H   OC 2 H 5     H       573   H-2   OC 2 H 5     H   OC 2 H 5     H       574   H-2   OCF 3     H   OC 2 H 5     H       575   H-2   F   H   OCF 3     H       576   H-2   Cl   H   OCF 3     H       577   H-2   CH 3     H   OCF 3     H       578   H-2   CF 3     H   OCF 3     H       579   H-2   CN   H   OCF 3     H       580   H-2   OCH 3     H   OCF 3     H       581   H-2   OC 2 H 5     H   OCF 3     H       582   H-2   OCF 3     H   OCF 3     H       583   H-2   F   H   H   F       584   H-2   Cl   H   H   F       585   H-2   CH 3     H   H   F       586   H-2   CF 3     H   H   F       587   H-2   CN   H   H   F       588   H-2   OCH 3     H   H   F       589   H-2   OC 2 H 5     H   H   F       590   H-2   OCF 3     H   H   F       591   H-2   F   H   H   Cl       592   H-2   Cl   H   H   Cl       593   H-2   CH 3     H   H   Cl       594   H-2   CF 3     H   H   Cl       595   H-2   CN   H   H   Cl       596   H-2   OCH 3     H   H   Cl       597   H-2   OC 2 H 5     H   H   Cl       598   H-2   OCF 3     H   H   Cl       599   H-2   F   H   H   CH 3         600   H-2   Cl   H   H   CH 3         601   H-2   CH 3     H   H   CH 3         602   H-2   CF 3     H   H   CH 3         603   H-2   CN   H   H   CH 3         604   H-2   OCH 3     H   H   CH 3         605   H-2   OC 2 H 5     H   H   CH 3         606   H-2   OCF 3     H   H   CH 3         607   H-2   F   H   H   CF 3         608   H-2   Cl   H   H   CF 3         609   H-2   CH 3     H   H   CF 3         610   H-2   CF 3     H   H   CF 3         611   H-2   CN   H   H   CF 3         612   H-2   OCH 3     H   H   CF 3         613   H-2   OC 2 H 5     H   H   CF 3         614   H-2   OCF 3     H   H   CF 3         615   H-2   F   H   H   CN       616   H-2   Cl   H   H   CN       617   H-2   CH 3     H   H   CN       618   H-2   CF 3     H   H   CN       619   H-2   CN   H   H   CN       620   H-2   OCH 3     H   H   CN       621   H-2   OC 2 H 5     H   H   CN       622   H-2   OCF 3     H   H   CN       623   H-2   F   H   H   OCH 3         624   H-2   Cl   H   H   OCH 3         625   H-2   CH 3     H   H   OCH 3         626   H-2   CF 3     H   H   OCH 3         627   H-2   CN   H   H   OCH 3         628   H-2   OCH 3     H   H   OCH 3         629   H-2   OC 2 H 5     H   H   OCH 3         630   H-2   OCF 3     H   H   OCH 3         631   H-2   F   H   H   OC 2 H 5         632   H-2   Cl   H   H   OC 2 H 5         633   H-2   CH 3     H   H   OC 2 H 5         634   H-2   CF 3     H   H   OC 2 H 5         635   H-2   CN   H   H   OC 2 H 5         636   H-2   OCH 3     H   H   OC 2 H 5         637   H-2   OC 2 H 5     H   H   OC 2 H 5         638   H-2   OCF 3     H   H   OC 2 H 5         639   H-2   F   H   H   OCF 3         640   H-2   Cl   H   H   OCF 3         641   H-2   CH 3     H   H   OCF 3         642   H-2   CF 3     H   H   OCF 3         643   H-2   CN   H   H   OCF 3         644   H-2   OCH 3     H   H   OCF 3         645   H-2   OC 2 H 5     H   H   OCF 3         646   H-2   OCF 3     H   H   OCF 3         647   H-2   H   F   F   H       648   H-2   H   Cl   F   H       649   H-2   H   CH 3     F   H       650   H-2   H   CF 3     F   H       651   H-2   H   CN   F   H       652   H-2   H   OCH 3     F   H       653   H-2   H   OC 2 H 5     F   H       654   H-2   H   OCF 3     F   H       655   H-2   H   F   Cl   H       656   H-2   H   Cl   Cl   H       657   H-2   H   CH 3     Cl   H       658   H-2   H   CF 3     Cl   H       659   H-2   H   CN   Cl   H       660   H-2   H   OCH 3     Cl   H       661   H-2   H   OC 2 H 5     Cl   H       662   H-2   H   OCF 3     Cl   H       663   H-2   H   F   CH 3     H       664   H-2   H   Cl   CH 3     H       665   H-2   H   CH 3     CH 3     H       666   H-2   H   CF 3     CH 3     H       667   H-2   H   CN   CH 3     H       668   H-2   H   OCH 3     CH 3     H       669   H-2   H   OC 2 H 5     CH 3     H       670   H-2   H   OCF 3     CH 3     H       671   H-2   H   F   CF 3     H       672   H-2   H   Cl   CF 3     H       673   H-2   H   CH 3     CF 3     H       674   H-2   H   CF 3     CF 3     H       675   H-2   H   CN   CF 3     H       676   H-2   H   OCH 3     CF 3     H       677   H-2   H   OC 2 H 5     CF 3     H       678   H-2   H   OCF 3     CF 3     H       679   H-2   H   F   CN   H       680   H-2   H   Cl   CN   H       681   H-2   H   CH 3     CN   H       682   H-2   H   CF 3     CN   H       683   H-2   H   CN   CN   H       684   H-2   H   OCH 3     CN   H       685   H-2   H   OC 2 H 5     CN   H       686   H-2   H   OCF 3     CN   H       687   H-2   H   F   OCH 3     H       688   H-2   H   Cl   OCH 3     H       689   H-2   H   CH 3     OCH 3     H       690   H-2   H   CF 3     OCH 3     H       691   H-2   H   CN   OCH 3     H       692   H-2   H   OCH 3     OCH 3     H       693   H-2   H   OC 2 H 5     OCH 3     H       694   H-2   H   OCF 3     OCH 3     H       695   H-2   H   F   OC 2 H 5     H       696   H-2   H   Cl   OC 2 H 5     H       697   H-2   H   CH 3     OC 2 H 5     H       698   H-2   H   CF 3     OC 2 H 5     H       699   H-2   H   CN   OC 2 H 5     H       700   H-2   H   OCH 3     OC 2 H 5     H       701   H-2   H   OC 2 H 5     OC 2 H 5     H       702   H-2   H   OCF 3     OC 2 H 5     H       703   H-2   H   F   OCF 3     H       704   H-2   H   Cl   OCF 3     H       705   H-2   H   CH 3     OCF 3     H       706   H-2   H   CF 3     OCF 3     H       707   H-2   H   CN   OCF 3     H       708   H-2   H   OCH 3     OCF 3     H       709   H-2   H   OC 2 H 5     OCF 3     H       710   H-2   H   OCF 3     OCF 3     H       711   H-2   H   F   H   F       712   H-2   H   Cl   H   F       713   H-2   H   Br   H   F       714   H-2   H   CH 3     H   F       715   H-2   H   CF 3     H   F       716   H-2   H   CN   H   F       717   H-2   H   OCH 3     H   F       718   H-2   H   OC 2 H 5     H   F       719   H-2   H   OCF 3     H   F       720   H-2   H   OCHF 2     H   F       721   H-2   H   F   H   Cl       722   H-2   H   Cl   H   Cl       723   H-2   H   CH 3     H   Cl       724   H-2   H   CF 3     H   Cl       725   H-2   H   CN   H   Cl       726   H-2   H   OCH 3     H   Cl       727   H-2   H   OC 2 H 5     H   Cl       728   H-2   H   OCF 3     H   Cl       729   H-2   H   F   H   CH 3         730   H-2   H   Cl   H   CH 3         731   H-2   H   CH 3     H   CH 3         732   H-2   H   CF 3     H   CH 3         733   H-2   H   CN   H   CH 3         734   H-2   H   OCH 3     H   CH 3         735   H-2   H   OC 2 H 5     H   CH 3         736   H-2   H   OCF 3     H   CH 3         737   H-2   H   F   H   CF 3         738   H-2   H   Cl   H   CF 3         739   H-2   H   CH 3     H   CF 3         740   H-2   H   CF 3     H   CF 3         741   H-2   H   CN   H   CF 3         742   H-2   H   OCH 3     H   CF 3         743   H-2   H   OC 2 H 5     H   CF 3         744   H-2   H   OCF 3     H   CF 3         745   H-2   H   F   H   CN       746   H-2   H   Cl   H   CN       747   H-2   H   CH 3     H   CN       748   H-2   H   CF 3     H   CN       749   H-2   H   CN   H   CN       750   H-2   H   OCH 3     H   CN       751   H-2   H   OC 2 H 5     H   CN       752   H-2   H   OCF 3     H   CN       753   H-2   H   F   H   OCH 3         754   H-2   H   Cl   H   OCH 3         755   H-2   H   CH 3     H   OCH 3         756   H-2   H   CF 3     H   OCH 3         757   H-2   H   CN   H   OCH 3         758   H-2   H   OCH 3     H   OCH 3         759   H-2   H   OC 2 H 5     H   OCH 3         760   H-2   H   OCF 3     H   OCH 3         761   H-2   H   F   H   OC 2 H 5         762   H-2   H   Cl   H   OC 2 H 5         763   H-2   H   CH 3     H   OC 2 H 5         764   H-2   H   CF 3     H   OC 2 H 5         765   H-2   H   CN   H   OC 2 H 5         766   H-2   H   OCH 3     H   OC 2 H 5         767   H-2   H   OC 2 H 5     H   OC 2 H 5         768   H-2   H   OCF 3     H   OC 2 H 5         769   H-2   H   F   H   OCF 3         770   H-2   H   Cl   H   OCF 3         771   H-2   H   CH 3     H   OCF 3         772   H-2   H   CF 3     H   OCF 3         773   H-2   H   CN   H   OCF 3         774   H-2   H   OCH 3     H   OCF 3         775   H-2   H   OC 2 H 5     H   OCF 3         776   H-2   H   OCF 3     H   OCF 3         777   H-2   H   H   F   F       778   H-2   H   H   Cl   F       779   H-2   H   H   CH 3     F       780   H-2   H   H   CF 3     F       781   H-2   H   H   CN   F       782   H-2   H   H   OCH 3     F       783   H-2   H   H   OC 2 H 5     F       784   H-2   H   H   OCF 3     F       785   H-2   H   H   F   Cl       786   H-2   H   H   Cl   Cl       787   H-2   H   H   CH 3     Cl       788   H-2   H   H   CF 3     Cl       789   H-2   H   H   CN   Cl       790   H-2   H   H   OCH 3     Cl       791   H-2   H   H   OC 2 H 5     Cl       792   H-2   H   H   OCF 3     Cl       793   H-2   H   H   F   CH 3         794   H-2   H   H   Cl   CH 3         795   H-2   H   H   CH 3     CH 3         796   H-2   H   H   CF 3     CH 3         797   H-2   H   H   CN   CH 3         798   H-2   H   H   OCH 3     CH 3         799   H-2   H   H   OC 2 H 5     CH 3         800   H-2   H   H   OCF 3     CH 3         801   H-2   H   H   F   CF 3         802   H-2   H   H   Cl   CF 3         803   H-2   H   H   CH 3     CF 3         804   H-2   H   H   CF 3     CF 3         805   H-2   H   H   CN   CF 3         806   H-2   H   H   OCH 3     CF 3         807   H-2   H   H   OC 2 H 5     CF 3         808   H-2   H   H   OCF 3     CF 3         809   H-2   H   H   F   CN       810   H-2   H   H   Cl   CN       811   H-2   H   H   CH 3     CN       812   H-2   H   H   CF 3     CN       813   H-2   H   H   CN   CN       814   H-2   H   H   OCH 3     CN       815   H-2   H   H   OC 2 H 5     CN       816   H-2   H   H   OCF 3     CN       817   H-2   H   H   F   OCH 3         818   H-2   H   H   Cl   OCH 3         819   H-2   H   H   CH 3     OCH 3         820   H-2   H   H   CF 3     OCH 3         821   H-2   H   H   CN   OCH 3         822   H-2   H   H   OCH 3     OCH 3         823   H-2   H   H   OC 2 H 5     OCH 3         824   H-2   H   H   OCF 3     OCH 3         825   H-2   H   H   F   OC 2 H 5         826   H-2   H   H   Cl   OC 2 H 5         827   H-2   H   H   CH 3     OC 2 H 5         828   H-2   H   H   CF 3     OC 2 H 5         829   H-2   H   H   CN   OC 2 H 5         830   H-2   H   H   OCH 3     OC 2 H 5         831   H-2   H   H   OC 2 H 5     OC 2 H 5         832   H-2   H   H   OCF 3     OC 2 H 5         833   H-2   H   H   F   OCF 3         834   H-2   H   H   Cl   OCF 3         835   H-2   H   H   CH 3     OCF 3         836   H-2   H   H   CF 3     OCF 3         837   H-2   H   H   CN   OCF 3         838   H-2   H   H   OCH 3     OCF 3         839   H-2   H   H   OC 2 H 5     OCF 3         840   H-2   H   H   OCF 3     OCF 3         841   H-3   H   H   H   H       842   H-3   F   H   H   H       843   H-3   Cl   H   H   H       844   H-3   CH 3     H   H   H       845   H-3   CF 3     H   H   H       846   H-3   CN   H   H   H       847   H-3   OCH 3     H   H   H       848   H-3   OC 2 H 5     H   H   H       849   H-3   OCF 3     H   H   H       850   H-3   H   F   H   H       851   H-3   H   Cl   H   H       852   H-3   H   CH 3     H   H       853   H-3   H   CF 3     H   H       854   H-3   H   CN   H   H       855   H-3   H   OCH 3     H   H       856   H-3   H   OC 2 H 5     H   H       857   H-3   H   OCF 3     H   H       858   H-3   H   H   F   H       859   H-3   H   H   Cl   H       860   H-3   H   H   CH 3     H       861   H-3   H   H   CF 3     H       862   H-3   H   H   CN   H       863   H-3   H   H   OCH 3     H       864   H-3   H   H   OC 2 H 5     H       865   H-3   H   H   OCF 3     H       866   H-3   H   H   H   F       867   H-3   H   H   H   Cl       868   H-3   H   H   H   CH 3         869   H-3   H   H   H   CF 3         870   H-3   H   H   H   CN       871   H-3   H   H   H   OCH 3         872   H-3   H   H   H   OC 2 H 5         873   H-3   H   H   H   OCF 3         874   H-3   F   F   H   H       875   H-3   Cl   F   H   H       876   H-3   CH 3     F   H   H       877   H-3   CF 3     F   H   H       878   H-3   CN   F   H   H       879   H-3   OCH 3     F   H   H       880   H-3   OC 2 H 5     F   H   H       881   H-3   OCF 3     F   H   H       882   H-3   F   Cl   H   H       883   H-3   Cl   Cl   H   H       884   H-3   CH 3     Cl   H   H       885   H-3   CF 3     Cl   H   H       886   H-3   CN   Cl   H   H       887   H-3   OCH 3     Cl   H   H       888   H-3   OC 2 H 5     Cl   H   H       889   H-3   OCF 3     Cl   H   H       890   H-3   F   CH 3     H   H       891   H-3   Cl   CH 3     H   H       892   H-3   CH 3     CH 3     H   H       893   H-3   CF 3     CH 3     H   H       894   H-3   CN   CH 3     H   H       895   H-3   OCH 3     CH 3     H   H       896   H-3   OC 2 H 5     CH 3     H   H       897   H-3   OCF 3     CH 3     H   H       898   H-3   F   CF 3     H   H       899   H-3   Cl   CF 3     H   H       900   H-3   CH 3     CF 3     H   H       901   H-3   CF 3     CF 3     H   H       902   H-3   CN   CF 3     H   H       903   H-3   OCH 3     CF 3     H   H       904   H-3   OC 2 H 5     CF 3     H   H       905   H-3   OCF 3     CF 3     H   H       906   H-3   F   CN   H   H       907   H-3   Cl   CN   H   H       908   H-3   CH 3     CN   H   H       909   H-3   CF 3     CN   H   H       910   H-3   CN   CN   H   H       911   H-3   OCH 3     CN   H   H       912   H-3   OC 2 H 5     CN   H   H       913   H-3   OCF 3     CN   H   H       914   H-3   F   OCH 3     H   H       915   H-3   Cl   OCH 3     H   H       916   H-3   CH 3     OCH 3     H   H       917   H-3   CF 3     OCH 3     H   H       918   H-3   CN   OCH 3     H   H       919   H-3   OCH 3     OCH 3     H   H       920   H-3   OC 2 H 5     OCH 3     H   H       921   H-3   OCF 3     OCH 3     H   H       922   H-3   F   OC 2 H 5     H   H       923   H-3   Cl   OC 2 H 5     H   H       924   H-3   CH 3     OC 2 H 5     H   H       925   H-3   CF 3     OC 2 H 5     H   H       926   H-3   CN   OC 2 H 5     H   H       927   H-3   OCH 3     OC 2 H 5     H   H       928   H-3   OC 2 H 5     OC 2 H 5     H   H       929   H-3   OCF 3     OC 2 H 5     H   H       930   H-3   F   OCF 3     H   H       931   H-3   Cl   OCF 3     H   H       932   H-3   CH 3     OCF 3     H   H       933   H-3   CF 3     OCF 3     H   H       934   H-3   CN   OCF 3     H   H       935   H-3   OCH 3     OCF 3     H   H       936   H-3   OC 2 H 5     OCF 3     H   H       937   H-3   OCF 3     OCF 3     H   H       938   H-3   F   H   F   H       939   H-3   Cl   H   F   H       940   H-3   CH 3     H   F   H       941   H-3   CF 3     H   F   H       942   H-3   CN   H   F   H       943   H-3   OCH 3     H   F   H       944   H-3   OC 2 H 5     H   F   H       945   H-3   OCF 3     H   F   H       946   H-3   F   H   Cl   H       947   H-3   Cl   H   Cl   H       948   H-3   CH 3     H   Cl   H       949   H-3   CF 3     H   Cl   H       950   H-3   CN   H   Cl   H       951   H-3   OCH 3     H   Cl   H       952   H-3   OC 2 H 5     H   Cl   H       953   H-3   OCF 3     H   Cl   H       954   H-3   F   H   CH 3     H       955   H-3   Cl   H   CH 3     H       956   H-3   CH 3     H   CH 3     H       957   H-3   CF 3     H   CH 3     H       958   H-3   CN   H   CH 3     H       959   H-3   OCH 3     H   CH 3     H       960   H-3   OC 2 H 5     H   CH 3     H       961   H-3   OCF 3     H   CH 3     H       962   H-3   F   H   CF 3     H       963   H-3   Cl   H   CF 3     H       964   H-3   CH 3     H   CF 3     H       965   H-3   CF 3     H   CF 3     H       966   H-3   CN   H   CF 3     H       967   H-3   OCH 3     H   CF 3     H       968   H-3   OC 2 H 5     H   CF 3     H       969   H-3   OCF 3     H   CF 3     H       970   H-3   F   H   CN   H       971   H-3   Cl   H   CN   H       972   H-3   CH 3     H   CN   H       973   H-3   CF 3     H   CN   H       974   H-3   CN   H   CN   H       975   H-3   OCH 3     H   CN   H       976   H-3   OC 2 H 5     H   CN   H       977   H-3   OCF 3     H   CN   H       978   H-3   OCHF 2     H   CN   H       979   H-3   F   H   OCH 3     H       980   H-3   Cl   H   OCH 3     H       981   H-3   CH 3     H   OCH 3     H       982   H-3   CF 3     H   OCH 3     H       983   H-3   CN   H   OCH 3     H       984   H-3   OCH 3     H   OCH 3     H       985   H-3   OC 2 H 5     H   OCH 3     H       986   H-3   OCF 3     H   OCH 3     H       987   H-3   F   H   OC 2 H 5     H       988   H-3   Cl   H   OC 2 H 5     H       989   H-3   CH 3     H   OC 2 H 5     H       990   H-3   CF 3     H   OC 2 H 5     H       991   H-3   CN   H   OC 2 H 5     H       992   H-3   OCH 3     H   OC 2 H 5     H       993   H-3   OC 2 H 5     H   OC 2 H 5     H       994   H-3   OCF 3     H   OC 2 H 5     H       995   H-3   F   H   OCF 3     H       996   H-3   Cl   H   OCF 3     H       997   H-3   CH 3     H   OCF 3     H       998   H-3   CF 3     H   OCF 3     H       999   H-3   CN   H   OCF 3     H       1000   H-3   OCH 3     H   OCF 3     H       1001   H-3   OC 2 H 5     H   OCF 3     H       1002   H-3   OCF 3     H   OCF 3     H       1003   H-3   F   H   H   F       1004   H-3   Cl   H   H   F       1005   H-3   CH 3     H   H   F       1006   H-3   CF 3     H   H   F       1007   H-3   CN   H   H   F       1008   H-3   OCH 3     H   H   F       1009   H-3   OC 2 H 5     H   H   F       1010   H-3   OCF 3     H   H   F       1011   H-3   F   H   H   Cl       1012   H-3   Cl   H   H   Cl       1013   H-3   CH 3     H   H   Cl       1014   H-3   CF 3     H   H   Cl       1015   H-3   CN   H   H   Cl       1016   H-3   OCH 3     H   H   Cl       1017   H-3   OC 2 H 5     H   H   Cl       1018   H-3   OCF 3     H   H   Cl       1019   H-3   F   H   H   CH 3         1020   H-3   Cl   H   H   CH 3         1021   H-3   CH 3     H   H   CH 3         1022   H-3   CF 3     H   H   CH 3         1023   H-3   CN   H   H   CH 3         1024   H-3   OCH 3     H   H   CH 3         1025   H-3   OC 2 H 5     H   H   CH 3         1026   H-3   OCF 3     H   H   CH 3         1027   H-3   F   H   H   CF 3         1028   H-3   Cl   H   H   CF 3         1029   H-3   CH 3     H   H   CF 3         1030   H-3   CF 3     H   H   CF 3         1031   H-3   CN   H   H   CF 3         1032   H-3   OCH 3     H   H   CF 3         1033   H-3   OC 2 H 5     H   H   CF 3         1034   H-3   OCF 3     H   H   CF 3         1035   H-3   F   H   H   CN       1036   H-3   Cl   H   H   CN       1037   H-3   CH 3     H   H   CN       1038   H-3   CF 3     H   H   CN       1039   H-3   CN   H   H   CN       1040   H-3   OCH 3     H   H   CN       1041   H-3   OC 2 H 5     H   H   CN       1042   H-3   OCF 3     H   H   CN       1043   H-3   F   H   H   OCH 3         1044   H-3   Cl   H   H   OCH 3         1045   H-3   CH 3     H   H   OCH 3         1046   H-3   CF 3     H   H   OCH 3         1047   H-3   CN   H   H   OCH 3         1048   H-3   OCH 3     H   H   OCH 3         1049   H-3   OC 2 H 5     H   H   OCH 3         1050   H-3   OCF 3     H   H   OCH 3         1051   H-3   F   H   H   OC 2 H 5         1052   H-3   Cl   H   H   OC 2 H 5         1053   H-3   CH 3     H   H   OC 2 H 5         1054   H-3   CF 3     H   H   OC 2 H 5         1055   H-3   CN   H   H   OC 2 H 5         1056   H-3   OCH 3     H   H   OC 2 H 5         1057   H-3   OC 2 H 5     H   H   OC 2 H 5         1058   H-3   OCF 3     H   H   OC 2 H 5         1059   H-3   F   H   H   OCF 3         1060   H-3   Cl   H   H   OCF 3         1061   H-3   CH 3     H   H   OCF 3         1062   H-3   CF 3     H   H   OCF 3         1063   H-3   CN   H   H   OCF 3         1064   H-3   OCH 3     H   H   OCF 3         1065   H-3   OC 2 H 5     H   H   OCF 3         1066   H-3   OCF 3     H   H   OCF 3         1067   H-3   H   F   F   H       1068   H-3   H   Cl   F   H       1069   H-3   H   CH 3     F   H       1070   H-3   H   CF 3     F   H       1071   H-3   H   CN   F   H       1072   H-3   H   OCH 3     F   H       1073   H-3   H   OC 2 H 5     F   H       1074   H-3   H   OCF 3     F   H       1075   H-3   H   F   Cl   H       1076   H-3   H   Cl   Cl   H       1077   H-3   H   CH 3     Cl   H       1078   H-3   H   CF 3     Cl   H       1079   H-3   H   CN   Cl   H       1080   H-3   H   OCH 3     Cl   H       1081   H-3   H   OC 2 H 5     Cl   H       1082   H-3   H   OCF 3     Cl   H       1083   H-3   H   F   CH 3     H       1084   H-3   H   Cl   CH 3     H       1085   H-3   H   CH 3     CH 3     H       1086   H-3   H   CF 3     CH 3     H       1087   H-3   H   CN   CH 3     H       1088   H-3   H   OCH 3     CH 3     H       1089   H-3   H   OC 2 H 5     CH 3     H       1090   H-3   H   OCF 3     CH 3     H       1091   H-3   H   F   CF 3     H       1092   H-3   H   Cl   CF 3     H       1093   H-3   H   CH 3     CF 3     H       1094   H-3   H   CF 3     CF 3     H       1095   H-3   H   CN   CF 3     H       1096   H-3   H   OCH 3     CF 3     H       1097   H-3   H   OC 2 H 5     CF 3     H       1098   H-3   H   OCF 3     CF 3     H       1099   H-3   H   F   CN   H       1100   H-3   H   Cl   CN   H       1101   H-3   H   CH 3     CN   H       1102   H-3   H   CF 3     CN   H       1103   H-3   H   CN   CN   H       1104   H-3   H   OCH 3     CN   H       1105   H-3   H   OC 2 H 5     CN   H       1106   H-3   H   OCF 3     CN   H       1107   H-3   H   F   OCH 3     H       1108   H-3   H   Cl   OCH 3     H       1109   H-3   H   CH 3     OCH 3     H       1110   H-3   H   CF 3     OCH 3     H       1111   H-3   H   CN   OCH 3     H       1112   H-3   H   OCH 3     OCH 3     H       1113   H-3   H   OC 2 H 5     OCH 3     H       1114   H-3   H   OCF 3     OCH 3     H       1115   H-3   H   F   OC 2 H 5     H       1116   H-3   H   Cl   OC 2 H 5     H       1117   H-3   H   CH 3     OC 2 H 5     H       1118   H-3   H   CF 3     OC 2 H 5     H       1119   H-3   H   CN   OC 2 H 5     H       1120   H-3   H   OCH 3     OC 2 H 5     H       1121   H-3   H   OC 2 H 5     OC 2 H 5     H       1122   H-3   H   OCF 3     OC 2 H 5     H       1123   H-3   H   F   OCF 3     H       1124   H-3   H   Cl   OCF 3     H       1125   H-3   H   CH 3     OCF 3     H       1126   H-3   H   CF 3     OCF 3     H       1127   H-3   H   CN   OCF 3     H       1128   H-3   H   OCH 3     OCF 3     H       1129   H-3   H   OC 2 H 5     OCF 3     H       1130   H-3   H   OCF 3     OCF 3     H       1131   H-3   H   F   H   F       1132   H-3   H   Cl   H   F       1133   H-3   H   Br   H   F       1134   H-3   H   CH 3     H   F       1135   H-3   H   CF 3     H   F       1136   H-3   H   CN   H   F       1137   H-3   H   OCH 3     H   F       1138   H-3   H   OC 2 H 5     H   F       1139   H-3   H   OCF 3     H   F       1140   H-3   H   OCHF 2     H   F       1141   H-3   H   F   H   Cl       1142   H-3   H   Cl   H   Cl       1143   H-3   H   CH 3     H   Cl       1144   H-3   H   CF 3     H   Cl       1145   H-3   H   CN   H   Cl       1146   H-3   H   OCH 3     H   Cl       1147   H-3   H   OC 2 H 5     H   Cl       1148   H-3   H   OCF 3     H   Cl       1149   H-3   H   F   H   CH 3         1150   H-3   H   Cl   H   CH 3         1151   H-3   H   CH 3     H   CH 3         1152   H-3   H   CF 3     H   CH 3         1153   H-3   H   CN   H   CH 3         1154   H-3   H   OCH 3     H   CH 3         1155   H-3   H   OC 2 H 5     H   CH 3         1156   H-3   H   OCF 3     H   CH 3         1157   H-3   H   F   H   CF 3         1158   H-3   H   Cl   H   CF 3         1159   H-3   H   CH 3     H   CF 3         1160   H-3   H   CF 3     H   CF 3         1161   H-3   H   CN   H   CF 3         1162   H-3   H   OCH 3     H   CF 3         1163   H-3   H   OC 2 H 5     H   CF 3         1164   H-3   H   OCF 3     H   CF 3         1165   H-3   H   F   H   CN       1166   H-3   H   Cl   H   CN       1167   H-3   H   CH 3     H   CN       1168   H-3   H   CF 3     H   CN       1169   H-3   H   CN   H   CN       1170   H-3   H   OCH 3     H   CN       1171   H-3   H   OC 2 H 5     H   CN       1172   H-3   H   OCF 3     H   CN       1173   H-3   H   F   H   OCH 3         1174   H-3   H   Cl   H   OCH 3         1175   H-3   H   CH 3     H   OCH 3         1176   H-3   H   CF 3     H   OCH 3         1177   H-3   H   CN   H   OCH 3         1178   H-3   H   OCH 3     H   OCH 3         1179   H-3   H   OC 2 H 5     H   OCH 3         1180   H-3   H   OCF 3     H   OCH 3         1181   H-3   H   F   H   OC 2 H 5         1182   H-3   H   Cl   H   OC 2 H 5         1183   H-3   H   CH 3     H   OC 2 H 5         1184   H-3   H   CF 3     H   OC 2 H 5         1185   H-3   H   CN   H   OC 2 H 5         1186   H-3   H   OCH 3     H   OC 2 H 5         1187   H-3   H   OC 2 H 5     H   OC 2 H 5         1188   H-3   H   OCF 3     H   OC 2 H 5         1189   H-3   H   F   H   OCF 3         1190   H-3   H   Cl   H   OCF 3         1191   H-3   H   CH 3     H   OCF 3         1192   H-3   H   CF 3     H   OCF 3         1193   H-3   H   CN   H   OCF 3         1194   H-3   H   OCH 3     H   OCF 3         1195   H-3   H   OC 2 H 5     H   OCF 3         1196   H-3   H   OCF 3     H   OCF 3         1197   H-3   H   H   F   F       1198   H-3   H   H   Cl   F       1199   H-3   H   H   CH 3     F       1200   H-3   H   H   CF 3     F       1201   H-3   H   H   CN   F       1202   H-3   H   H   OCH 3     F       1203   H-3   H   H   OC 2 H 5     F       1204   H-3   H   H   OCF 3     F       1205   H-3   H   H   F   Cl       1206   H-3   H   H   Cl   Cl       1207   H-3   H   H   CH 3     Cl       1208   H-3   H   H   CF 3     Cl       1209   H-3   H   H   CN   Cl       1210   H-3   H   H   OCH 3     Cl       1211   H-3   H   H   OC 2 H 5     Cl       1212   H-3   H   H   OCF 3     Cl       1213   H-3   H   H   F   CH 3         1214   H-3   H   H   Cl   CH 3         1215   H-3   H   H   CH 3     CH 3         1216   H-3   H   H   CF 3     CH 3         1217   H-3   H   H   CN   CH 3         1218   H-3   H   H   OCH 3     CH 3         1219   H-3   H   H   OC 2 H 5     CH 3         1220   H-3   H   H   OCF 3     CH 3         1221   H-3   H   H   F   CF 3         1222   H-3   H   H   Cl   CF 3         1223   H-3   H   H   CH 3     CF 3         1224   H-3   H   H   CF 3     CF 3         1225   H-3   H   H   CN   CF 3         1226   H-3   H   H   OCH 3     CF 3         1227   H-3   H   H   OC 2 H 5     CF 3         1228   H-3   H   H   OCF 3     CF 3         1229   H-3   H   H   F   CN       1230   H-3   H   H   Cl   CN       1231   H-3   H   H   CH 3     CN       1232   H-3   H   H   CF 3     CN       1233   H-3   H   H   CN   CN       1234   H-3   H   H   OCH 3     CN       1235   H-3   H   H   OC 2 H 5     CN       1236   H-3   H   H   OCF 3     CN       1237   H-3   H   H   F   OCH 3         1238   H-3   H   H   Cl   OCH 3         1239   H-3   H   H   CH 3     OCH 3         1240   H-3   H   H   CF 3     OCH 3         1241   H-3   H   H   CN   OCH 3         1242   H-3   H   H   OCH 3     OCH 3         1243   H-3   H   H   OC 2 H 5     OCH 3         1244   H-3   H   H   OCF 3     OCH 3         1245   H-3   H   H   F   OC 2 H 5         1246   H-3   H   H   Cl   OC 2 H 5         1247   H-3   H   H   CH 3     OC 2 H 5         1248   H-3   H   H   CF 3     OC 2 H 5         1249   H-3   H   H   CN   OC 2 H 5         1250   H-3   H   H   OCH 3     OC 2 H 5         1251   H-3   H   H   OC 2 H 5     OC 2 H 5         1252   H-3   H   H   OCF 3     OC 2 H 5         1253   H-3   H   H   F   OCF 3         1254   H-3   H   H   Cl   OCF 3         1255   H-3   H   H   CH 3     OCF 3         1256   H-3   H   H   CF 3     OCF 3         1257   H-3   H   H   CN   OCF 3         1258   H-3   H   H   OCH 3     OCF 3         1259   H-3   H   H   OC 2 H 5     OCF 3         1260   H-3   H   H   OCF 3     OCF 3         1261   H-4   H   H   H       1262   H-4   F   H   H       1263   H-4   Cl   H   H       1264   H-4   CH 3     H   H       1265   H-4   CF 3     H   H       1266   H-4   CN   H   H       1267   H-4   OCH 3     H   H       1268   H-4   OC 2 H 5     H   H       1269   H-4   OCF 3     H   H       1270   H-4   H   F   H       1271   H-4   H   Cl   H       1272   H-4   H   CH 3     H       1273   H-4   H   CF 3     H       1274   H-4   H   CN   H       1275   H-4   H   OCH 3     H       1276   H-4   H   OC 2 H 5     H       1277   H-4   H   OCF 3     H       1278   H-4   F   F   H       1279   H-4   Cl   F   H       1280   H-4   CH 3     F   H       1281   H-4   CF 3     F   H       1282   H-4   CN   F   H       1283   H-4   OCH 3     F   H       1284   H-4   OC 2 H 5     F   H       1285   H-4   OCF 3     F   H       1286   H-4   F   Cl   H       1287   H-4   Cl   Cl   H       1288   H-4   CH 3     Cl   H       1289   H-4   CF 3     Cl   H       1290   H-4   CN   Cl   H       1291   H-4   OCH 3     Cl   H       1292   H-4   OC 2 H 5     Cl   H       1293   H-4   OCF 3     Cl   H       1294   H-4   F   CH 3     H       1295   H-4   Cl   CH 3     H       1296   H-4   CH 3     CH 3     H       1297   H-4   CF 3     CH 3     H       1298   H-4   CN   CH 3     H       1299   H-4   OCH 3     CH 3     H       1300   H-4   OC 2 H 5     CH 3     H       1301   H-4   OCF 3     CH 3     H       1302   H-4   F   CF 3     H       1303   H-4   Cl   CF 3     H       1304   H-4   CH 3     CF 3     H       1305   H-4   CF 3     CF 3     H       1306   H-4   CN   CF 3     H       1307   H-4   OCH 3     CF 3     H       1308   H-4   OC 2 H 5     CF 3     H       1309   H-4   OCF 3     CF 3     H       1310   H-4   F   CN   H       1311   H-4   Cl   CN   H       1312   H-4   CH 3     CN   H       1313   H-4   CF 3     CN   H       1314   H-4   CN   CN   H       1315   H-4   OCH 3     CN   H       1316   H-4   OC 2 H 5     CN   H       1317   H-4   OCF 3     CN   H       1318   H-4   F   OCH 3     H       1319   H-4   Cl   OCH 3     H       1320   H-4   CH 3     OCH 3     H       1321   H-4   CF 3     OCH 3     H       1322   H-4   CN   OCH 3     H       1323   H-4   OCH 3     OCH 3     H       1324   H-4   OC 2 H 5     OCH 3     H       1325   H-4   OCF 3     OCH 3     H       1326   H-4   F   OC 2 H 5     H       1327   H-4   Cl   OC 2 H 5     H       1328   H-4   CH 3     OC 2 H 5     H       1329   H-4   CF 3     OC 2 H 5     H       1330   H-4   CN   OC 2 H 5     H       1331   H-4   OCH 3     OC 2 H 5     H       1332   H-4   OC 2 H 5     OC 2 H 5     H       1333   H-4   OCF 3     OC 2 H 5     H       1334   H-4   F   OCF 3     H       1335   H-4   Cl   OCF 3     H       1336   H-4   CH 3     OCF 3     H       1337   H-4   CF 3     OCF 3     H       1338   H-4   CN   OCF 3     H       1339   H-4   OCH 3     OCF 3     H       1340   H-4   OC 2 H 5     OCF 3     H       1341   H-4   OCF 3     OCF 3     H       1342   H-4   F   H   F       1343   H-4   Cl   H   F       1344   H-4   CH 3     H   F       1345   H-4   CF 3     H   F       1346   H-4   CN   H   F       1347   H-4   OCH 3     H   F       1348   H-4   OC 2 H 5     H   F       1349   H-4   OCF 3     H   F       1350   H-4   F   H   Cl       1351   H-4   Cl   H   Cl       1352   H-4   CH 3     H   Cl       1353   H-4   CF 3     H   Cl       1354   H-4   CN   H   Cl       1355   H-4   OCH 3     H   Cl       1356   H-4   OC 2 H 5     H   Cl       1357   H-4   OCF 3     H   Cl       1358   H-4   F   H   CH 3         1359   H-4   Cl   H   CH 3         1360   H-4   CH 3     H   CH 3         1361   H-4   CF 3     H   CH 3         1362   H-4   CN   H   CH 3         1363   H-4   OCH 3     H   CH 3         1364   H-4   OC 2 H 5     H   CH 3         1365   H-4   OCF 3     H   CH 3         1366   H-4   F   H   CF 3         1367   H-4   Cl   H   CF 3         1368   H-4   CH 3     H   CF 3         1369   H-4   CF 3     H   CF 3         1370   H-4   CN   H   CF 3         1371   H-4   OCH 3     H   CF 3         1372   H-4   OC 2 H 5     H   CF 3         1373   H-4   OCF 3     H   CF 3         1374   H-4   F   H   CN       1375   H-4   Cl   H   CN       1376   H-4   CH 3     H   CN       1377   H-4   CF 3     H   CN       1378   H-4   CN   H   CN       1379   H-4   OCH 3     H   CN       1380   H-4   OC 2 H 5     H   CN       1381   H-4   OCF 3     H   CN       1382   H-4   F   H   OCH 3         1383   H-4   Cl   H   OCH 3         1384   H-4   Br   H   OCH 3         1385   H-4   CH 3     H   OCH 3         1386   H-4   CF 3     H   OCH 3         1387   H-4   CN   H   OCH 3         1388   H-4   OCH 3     H   OCH 3         1389   H-4   OC 2 H 5     H   OCH 3         1390   H-4   OCF 3     H   OCH 3         1391   H-4   OCHF 2     H   OCH 3         1392   H-4   F   H   OC 2 H 5         1393   H-4   Cl   H   OC 2 H 5         1394   H-4   CH 3     H   OC 2 H 5         1395   H-4   CF 3     H   OC 2 H 5         1396   H-4   CN   H   OC 2 H 5         1397   H-4   OCH 3     H   OC 2 H 5         1398   H-4   OC 2 H 5     H   OC 2 H 5         1399   H-4   OCF 3     H   OC 2 H 5         1400   H-4   F   H   OCF 3         1401   H-4   Cl   H   OCF 3         1402   H-4   CH 3     H   OCF 3         1403   H-4   CF 3     H   OCF 3         1404   H-4   CN   H   OCF 3         1405   H-4   OCH 3     H   OCF 3         1406   H-4   OC 2 H 5     H   OCF 3         1407   H-4   OCF 3     H   OCF 3         1408   H-5   H   H   H       1409   H-5   F   H   H       1410   H-5   Cl   H   H       1411   H-5   CH 3     H   H       1412   H-5   CF 3     H   H       1413   H-5   CN   H   H       1414   H-5   OCH 3     H   H       1415   H-5   OC 2 H 5     H   H       1416   H-5   OCF 3     H   H       1417   H-5   H   F   H       1418   H-5   H   Cl   H       1419   H-5   H   CH 3     H       1420   H-5   H   CF 3     H       1421   H-5   H   CN   H       1422   H-5   H   OCH 3     H       1423   H-5   H   OC 2 H 5     H       1424   H-5   H   OCF 3     H       1425   H-5   H   H   F       1426   H-5   H   H   Cl       1427   H-5   H   H   CH 3         1428   H-5   H   H   CF 3         1429   H-5   H   H   CN       1430   H-5   H   H   OCH 3         1431   H-5   H   H   OC 2 H 5         1432   H-5   H   H   OCF 3         1433   H-5   F   F   H       1434   H-5   Cl   F   H       1435   H-5   CH 3     F   H       1436   H-5   CF 3     F   H       1437   H-5   CN   F   H       1438   H-5   OCH 3     F   H       1439   H-5   OC 2 H 5     F   H       1440   H-5   OCF 3     F   H       1441   H-5   F   Cl   H       1442   H-5   Cl   Cl   H       1443   H-5   CH 3     Cl   H       1444   H-5   CF 3     Cl   H       1445   H-5   CN   Cl   H       1446   H-5   OCH 3     Cl   H       1447   H-5   OC 2 H 5     Cl   H       1448   H-5   OCF 3     Cl   H       1449   H-5   F   CH 3     H       1450   H-5   Cl   CH 3     H       1451   H-5   CH 3     CH 3     H       1452   H-5   CF 3     CH 3     H       1453   H-5   CN   CH 3     H       1454   H-5   OCH 3     CH 3     H       1455   H-5   OC 2 H 5     CH 3     H       1456   H-5   OCF 3     CH 3     H       1457   H-5   F   CF 3     H       1458   H-5   Cl   CF 3     H       1459   H-5   CH 3     CF 3     H       1460   H-5   CF 3     CF 3     H       1461   H-5   CN   CF 3     H       1462   H-5   OCH 3     CF 3     H       1463   H-5   OC 2 H 5     CF 3     H       1464   H-5   OCF 3     CF 3     H       1465   H-5   F   CN   H       1466   H-5   Cl   CN   H       1467   H-5   CH 3     CN   H       1468   H-5   CF 3     CN   H       1469   H-5   CN   CN   H       1470   H-5   OCH 3     CN   H       1471   H-5   OC 2 H 5     CN   H       1472   H-5   OCF 3     CN   H       1473   H-5   F   OCH 3     H       1474   H-5   Cl   OCH 3     H       1475   H-5   CH 3     OCH 3     H       1476   H-5   CF 3     OCH 3     H       1477   H-5   CN   OCH 3     H       1478   H-5   OCH 3     OCH 3     H       1479   H-5   OC 2 H 5     OCH 3     H       1480   H-5   OCF 3     OCH 3     H       1481   H-5   F   OC 2 H 5     H       1482   H-5   Cl   OC 2 H 5     H       1483   H-5   CH 3     OC 2 H 5     H       1484   H-5   CF 3     OC 2 H 5     H       1485   H-5   CN   OC 2 H 5     H       1486   H-5   OCH 3     OC 2 H 5     H       1487   H-5   OC 2 H 5     OC 2 H 5     H       1488   H-5   OCF 3     OC 2 H 5     H       1489   H-5   F   OCF 3     H       1490   H-5   Cl   OCF 3     H       1491   H-5   CH 3     OCF 3     H       1492   H-5   CF 3     OCF 3     H       1493   H-5   CN   OCF 3     H       1494   H-5   OCH 3     OCF 3     H       1495   H-5   OC 2 H 5     OCF 3     H       1496   H-5   OCF 3     OCF 3     H       1497   H-5   F   H   F       1498   H-5   Cl   H   F       1499   H-5   CH 3     H   F       1500   H-5   CF 3     H   F       1501   H-5   CN   H   F       1502   H-5   OCH 3     H   F       1503   H-5   OC 2 H 5     H   F       1504   H-5   OCF 3     H   F       1505   H-5   F   H   Cl       1506   H-5   Cl   H   Cl       1507   H-5   CH 3     H   Cl       1508   H-5   CF 3     H   Cl       1509   H-5   CN   H   Cl       1510   H-5   OCH 3     H   Cl       1511   H-5   OC 2 H 5     H   Cl       1512   H-5   OCF 3     H   Cl       1513   H-5   F   H   CH 3         1514   H-5   Cl   H   CH 3         1515   H-5   CH 3     H   CH 3         1516   H-5   CF 3     H   CH 3         1517   H-5   CN   H   CH 3         1518   H-5   OCH 3     H   CH 3         1519   H-5   OC 2 H 5     H   CH 3         1520   H-5   OCF 3     H   CH 3         1521   H-5   F   H   CF 3         1522   H-5   Cl   H   CF 3         1523   H-5   CH 3     H   CF 3         1524   H-5   CF 3     H   CF 3         1525   H-5   CN   H   CF 3         1526   H-5   OCH 3     H   CF 3         1527   H-5   OC 2 H 5     H   CF 3         1528   H-5   OCF 3     H   CF 3         1529   H-5   F   H   CN       1530   H-5   Cl   H   CN       1531   H-5   CH 3     H   CN       1532   H-5   CF 3     H   CN       1533   H-5   CN   H   CN       1534   H-5   OCH 3     H   CN       1535   H-5   OC 2 H 5     H   CN       1536   H-5   OCF 3     H   CN       1537   H-5   F   H   OCH 3         1538   H-5   Cl   H   OCH 3         1539   H-5   CH 3     H   OCH 3         1540   H-5   CF 3     H   OCH 3         1541   H-5   CN   H   OCH 3         1542   H-5   OCH 3     H   OCH 3         1543   H-5   OC 2 H 5     H   OCH 3         1544   H-5   OCF 3     H   OCH 3         1545   H-5   F   H   OC 2 H 5         1546   H-5   Cl   H   OC 2 H 5         1547   H-5   CH 3     H   OC 2 H 5         1548   H-5   CF 3     H   OC 2 H 5         1549   H-5   CN   H   OC 2 H 5         1550   H-5   OCH 3     H   OC 2 H 5         1551   H-5   OC 2 H 5     H   OC 2 H 5         1552   H-5   OCF 3     H   OC 2 H 5         1553   H-5   F   H   OCF 3         1554   H-5   Cl   H   OCF 3         1555   H-5   CH 3     H   OCF 3         1556   H-5   CF 3     H   OCF 3         1557   H-5   CN   H   OCF 3         1558   H-5   OCH 3     H   OCF 3         1559   H-5   OC 2 H 5     H   OCF 3         1560   H-5   OCF 3     H   OCF 3         1561   H-5   H   F   F       1562   H-5   H   Cl   F       1563   H-5   H   CH 3     F       1564   H-5   H   CF 3     F       1565   H-5   H   CN   F       1566   H-5   H   OCH 3     F       1567   H-5   H   OC 2 H 5     F       1568   H-5   H   OCF 3     F       1569   H-5   H   F   Cl       1570   H-5   H   Cl   Cl       1571   H-5   H   CH 3     Cl       1572   H-5   H   CF 3     Cl       1573   H-5   H   CN   Cl       1574   H-5   H   OCH 3     Cl       1575   H-5   H   OC 2 H 5     Cl       1576   H-5   H   OCF 3     Cl       1577   H-5   H   F   CH 3         1578   H-5   H   Cl   CH 3         1579   H-5   H   CH 3     CH 3         1580   H-5   H   CF 3     CH 3         1581   H-5   H   CN   CH 3         1582   H-5   H   OCH 3     CH 3         1583   H-5   H   OC 2 H 5     CH 3         1584   H-5   H   OCF 3     CH 3         1585   H-5   H   F   CF 3         1586   H-5   H   Cl   CF 3         1587   H-5   H   CH 3     CF 3         1588   H-5   H   CF 3     CF 3         1589   H-5   H   CN   CF 3         1590   H-5   H   OCH 3     CF 3         1591   H-5   H   OC 2 H 5     CF 3         1592   H-5   H   OCF 3     CF 3         1593   H-5   H   F   CN       1594   H-5   H   Cl   CN       1595   H-5   H   CH 3     CN       1596   H-5   H   CF 3     CN       1597   H-5   H   CN   CN       1598   H-5   H   OCH 3     CN       1599   H-5   H   OC 2 H 5     CN       1600   H-5   H   OCF 3     CN       1601   H-5   H   F   OCH 3         1602   H-5   H   Cl   OCH 3         1603   H-5   H   CH 3     OCH 3         1604   H-5   H   CF 3     OCH 3         1605   H-5   H   CN   OCH 3         1606   H-5   H   OCH 3     OCH 3         1607   H-5   H   OC 2 H 5     OCH 3         1608   H-5   H   OCF 3     OCH 3         1609   H-5   H   F   OC 2 H 5         1610   H-5   H   Cl   OC 2 H 5         1611   H-5   H   CH 3     OC 2 H 5         1612   H-5   H   CF 3     OC 2 H 5         1613   H-5   H   CN   OC 2 H 5         1614   H-5   H   OCH 3     OC 2 H 5         1615   H-5   H   OC 2 H 5     OC 2 H 5         1616   H-5   H   OCF 3     OC 2 H 5         1617   H-5   H   F   OCF 3         1618   H-5   H   Cl   OCF 3         1619   H-5   H   CH 3     OCF 3         1620   H-5   H   CF 3     OCF 3         1621   H-5   H   CN   OCF 3         1622   H-5   H   OCH 3     OCF 3         1623   H-5   H   OC 2 H 5     OCF 3         1624   H-5   H   OCF 3     OCF 3         1625   H-6   H   H   H       1626   H-6   F   H   H       1627   H-6   Cl   H   H       1628   H-6   CH 3     H   H       1629   H-6   CF 3     H   H       1630   H-6   CN   H   H       1631   H-6   OCH 3     H   H       1632   H-6   OC 2 H 5     H   H       1633   H-6   OCF 3     H   H       1634   H-6   H   F   H       1635   H-6   H   Cl   H       1636   H-6   H   CH 3     H       1637   H-6   H   CF 3     H       1638   H-6   H   CN   H       1639   H-6   H   OCH 3     H       1640   H-6   H   OC 2 H 5     H       1641   H-6   H   OCF 3     H       1642   H-6   F   F   H       1643   H-6   Cl   F   H       1644   H-6   CH 3     F   H       1645   H-6   CF 3     F   H       1646   H-6   CN   F   H       1647   H-6   OCH 3     F   H       1648   H-6   OC 2 H 5     F   H       1649   H-6   OCF 3     F   H       1650   H-6   F   Cl   H       1651   H-6   Cl   Cl   H       1652   H-6   CH 3     Cl   H       1653   H-6   CF 3     Cl   H       1654   H-6   CN   Cl   H       1655   H-6   OCH 3     Cl   H       1656   H-6   OC 2 H 5     Cl   H       1657   H-6   OCF 3     Cl   H       1658   H-6   F   CH 3     H       1659   H-6   Cl   CH 3     H       1660   H-6   CH 3     CH 3     H       1661   H-6   CF 3     CH 3     H       1662   H-6   CN   CH 3     H       1663   H-6   OCH 3     CH 3     H       1664   H-6   OC 2 H 5     CH 3     H       1665   H-6   OCF 3     CH 3     H       1666   H-6   F   CF 3     H       1667   H-6   Cl   CF 3     H       1668   H-6   CH 3     CF 3     H       1669   H-6   CF 3     CF 3     H       1670   H-6   CN   CF 3     H       1671   H-6   OCH 3     CF 3     H       1672   H-6   OC 2 H 5     CF 3     H       1673   H-6   OCF 3     CF 3     H       1674   H-6   F   CN   H       1675   H-6   Cl   CN   H       1676   H-6   CH 3     CN   H       1677   H-6   CF 3     CN   H       1678   H-6   CN   CN   H       1679   H-6   OCH 3     CN   H       1680   H-6   OC 2 H 5     CN   H       1681   H-6   OCF 3     CN   H       1682   H-6   F   OCH 3     H       1683   H-6   Cl   OCH 3     H       1684   H-6   CH 3     OCH 3     H       1685   H-6   CF 3     OCH 3     H       1686   H-6   CN   OCH 3     H       1687   H-6   OCH 3     OCH 3     H       1688   H-6   OC 2 H 5     OCH 3     H       1689   H-6   OCF 3     OCH 3     H       1690   H-6   F   OC 2 H 5     H       1691   H-6   Cl   OC 2 H 5     H       1692   H-6   CH 3     OC 2 H 5     H       1693   H-6   CF 3     OC 2 H 5     H       1694   H-6   CN   OC 2 H 5     H       1695   H-6   OCH 3     OC 2 H 5     H       1696   H-6   OC 2 H 5     OC 2 H 5     H       1697   H-6   OCF 3     OC 2 H 5     H       1698   H-6   F   OCF 3     H       1699   H-6   Cl   OCF 3     H       1700   H-6   CH 3     OCF 3     H       1701   H-6   CF 3     OCF 3     H       1702   H-6   CN   OCF 3     H       1703   H-6   OCH 3     OCF 3     H       1704   H-6   OC 2 H 5     OCF 3     H       1705   H-6   OCF 3     OCF 3     H       1706   H-6   H   F   F       1707   H-6   H   Cl   F       1708   H-6   H   CH 3     F       1709   H-6   H   CF 3     F       1710   H-6   H   CN   F       1711   H-6   H   OCH 3     F       1712   H-6   H   OC 2 H 5     F       1713   H-6   H   OCF 3     F       1714   H-6   H   F   Cl       1715   H-6   H   Cl   Cl       1716   H-6   H   CH 3     Cl       1717   H-6   H   CF 3     Cl       1718   H-6   H   CN   Cl       1719   H-6   H   OCH 3     Cl       1720   H-6   H   OC 2 H 5     Cl       1721   H-6   H   OCF 3     Cl       1722   H-6   H   F   CH 3         1723   H-6   H   Cl   CH 3         1724   H-6   H   CH 3     CH 3         1725   H-6   H   CF 3     CH 3         1726   H-6   H   CN   CH 3         1727   H-6   H   OCH 3     CH 3         1728   H-6   H   OC 2 H 5     CH 3         1729   H-6   H   OCF 3     CH 3         1730   H-6   H   F   CF 3         1731   H-6   H   Cl   CF 3         1732   H-6   H   CH 3     CF 3         1733   H-6   H   CF 3     CF 3         1734   H-6   H   CN   CF 3         1735   H-6   H   OCH 3     CF 3         1736   H-6   H   OC 2 H 5     CF 3         1737   H-6   H   OCF 3     CF 3         1738   H-6   H   F   CN       1739   H-6   H   Cl   CN       1740   H-6   H   CH 3     CN       1741   H-6   H   CF 3     CN       1742   H-6   H   CN   CN       1743   H-6   H   OCH 3     CN       1744   H-6   H   OC 2 H 5     CN       1745   H-6   H   OCF 3     CN       1746   H-6   H   F   OCH 3         1747   H-6   H   Cl   OCH 3         1748   H-6   H   CH 3     OCH 3         1749   H-6   H   CF 3     OCH 3         1750   H-6   H   CN   OCH 3         1751   H-6   H   OCH 3     OCH 3         1752   H-6   H   OC 2 H 5     OCH 3         1753   H-6   H   OCF 3     OCH 3         1754   H-6   H   F   OC 2 H 5         1755   H-6   H   Cl   OC 2 H 5         1756   H-6   H   CH 3     OC 2 H 5         1757   H-6   H   CF 3     OC 2 H 5         1758   H-6   H   CN   OC 2 H 5         1759   H-6   H   OCH 3     OC 2 H 5         1760   H-6   H   OC 2 H 5     OC 2 H 5         1761   H-6   H   OCF 3     OC 2 H 5         1762   H-6   H   F   OCF 3         1763   H-6   H   Cl   OCF 3         1764   H-6   H   CH 3     OCF 3         1765   H-6   H   CF 3     OCF 3         1766   H-6   H   CN   OCF 3         1767   H-6   H   OCH 3     OCF 3         1768   H-6   H   OC 2 H 5     OCF 3         1769   H-6   H   OCF 3     OCF 3         1770   H-7   H   H   H       1771   H-7   F   H   H       1772   H-7   Cl   H   H       1773   H-7   CH 3     H   H       1774   H-7   CF 3     H   H       1775   H-7   CN   H   H       1776   H-7   OCH 3     H   H       1777   H-7   OC 2 H 5     H   H       1778   H-7   OCF 3     H   H       1779   H-7   H   F   H       1780   H-7   H   Cl   H       1781   H-7   H   CH 3     H       1782   H-7   H   CF 3     H       1783   H-7   H   CN   H       1784   H-7   H   OCH 3     H       1785   H-7   H   OC 2 H 5     H       1786   H-7   H   OCF 3     H       1787   H-7   H   H   F       1788   H-7   H   H   Cl       1789   H-7   H   H   CH 3         1790   H-7   H   H   CF 3         1791   H-7   H   H   CN       1792   H-7   H   H   OCH 3         1793   H-7   H   H   OC 2 H 5         1794   H-7   H   H   OCF 3         1795   H-7   F   F   H       1796   H-7   Cl   F   H       1797   H-7   CH 3     F   H       1798   H-7   CF 3     F   H       1799   H-7   CN   F   H       1800   H-7   OCH 3     F   H       1801   H-7   OC 2 H 5     F   H       1802   H-7   OCF 3     F   H       1803   H-7   F   Cl   H       1804   H-7   Cl   Cl   H       1805   H-7   CH 3     Cl   H       1806   H-7   CF 3     Cl   H       1807   H-7   CN   Cl   H       1808   H-7   OCH 3     Cl   H       1809   H-7   OC 2 H 5     Cl   H       1810   H-7   OCF 3     Cl   H       1811   H-7   F   CH 3     H       1812   H-7   Cl   CH 3     H       1813   H-7   Br   CH 3     H       1814   H-7   CH 3     CH 3     H       1815   H-7   CF 3     CH 3     H       1816   H-7   CN   CH 3     H       1817   H-7   OCH 3     CH 3     H       1818   H-7   OC 2 H 5     CH 3     H       1819   H-7   OCF 3     CH 3     H       1820   H-7   OCHF 2     CH 3     H       1821   H-7   F   CF 3     H       1822   H-7   Cl   CF 3     H       1823   H-7   CH 3     CF 3     H       1824   H-7   CF 3     CF 3     H       1825   H-7   CN   CF 3     H       1826   H-7   OCH 3     CF 3     H       1827   H-7   OC 2 H 5     CF 3     H       1828   H-7   OCF 3     CF 3     H       1829   H-7   F   CN   H       1830   H-7   Cl   CN   H       1831   H-7   CH 3     CN   H       1832   H-7   CF 3     CN   H       1833   H-7   CN   CN   H       1834   H-7   OCH 3     CN   H       1835   H-7   OC 2 H 5     CN   H       1836   H-7   OCF 3     CN   H       1837   H-7   F   OCH 3     H       1838   H-7   Cl   OCH 3     H       1839   H-7   CH 3     OCH 3     H       1840   H-7   CF 3     OCH 3     H       1841   H-7   CN   OCH 3     H       1842   H-7   OCH 3     OCH 3     H       1843   H-7   OC 2 H 5     OCH 3     H       1844   H-7   OCF 3     OCH 3     H       1845   H-7   F   OC 2 H 5     H       1846   H-7   Cl   OC 2 H 5     H       1847   H-7   CH 3     OC 2 H 5     H       1848   H-7   CF 3     OC 2 H 5     H       1849   H-7   CN   OC 2 H 5     H       1850   H-7   OCH 3     OC 2 H 5     H       1851   H-7   OC 2 H 5     OC 2 H 5     H       1852   H-7   OCF 3     OC 2 H 5     H       1853   H-7   F   OCF 3     H       1854   H-7   Cl   OCF 3     H       1855   H-7   CH 3     OCF 3     H       1856   H-7   CF 3     OCF 3     H       1857   H-7   CN   OCF 3     H       1858   H-7   OCH 3     OCF 3     H       1859   H-7   OC 2 H 5     OCF 3     H       1860   H-7   OCF 3     OCF 3     H       1861   H-7   F   H   F       1862   H-7   Cl   H   F       1863   H-7   CH 3     H   F       1864   H-7   CF 3     H   F       1865   H-7   CN   H   F       1866   H-7   OCH 3     H   F       1867   H-7   OC 2 H 5     H   F       1868   H-7   OCF 3     H   F       1869   H-7   F   H   Cl       1870   H-7   Cl   H   Cl       1871   H-7   CH 3     H   Cl       1872   H-7   CF 3     H   Cl       1873   H-7   CN   H   Cl       1874   H-7   OCH 3     H   Cl       1875   H-7   OC 2 H 5     H   Cl       1876   H-7   OCF 3     H   Cl       1877   H-7   F   H   CH 3         1878   H-7   Cl   H   CH 3         1879   H-7   CH 3     H   CH 3         1880   H-7   CF 3     H   CH 3         1881   H-7   CN   H   CH 3         1882   H-7   OCH 3     H   CH 3         1883   H-7   OC 2 H 5     H   CH 3         1884   H-7   OCF 3     H   CH 3         1885   H-7   F   H   CF 3         1886   H-7   Cl   H   CF 3         1887   H-7   CH 3     H   CF 3         1888   H-7   CF 3     H   CF 3         1889   H-7   CN   H   CF 3         1890   H-7   OCH 3     H   CF 3         1891   H-7   OC 2 H 5     H   CF 3         1892   H-7   OCF 3     H   CF 3         1893   H-7   F   H   CN       1894   H-7   Cl   H   CN       1895   H-7   CH 3     H   CN       1896   H-7   CF 3     H   CN       1897   H-7   CN   H   CN       1898   H-7   OCH 3     H   CN       1899   H-7   OC 2 H 5     H   CN       1900   H-7   OCF 3     H   CN       1901   H-7   F   H   OCH 3         1902   H-7   Cl   H   OCH 3         1903   H-7   CH 3     H   OCH 3         1904   H-7   CF 3     H   OCH 3         1905   H-7   CN   H   OCH 3         1906   H-7   OCH 3     H   OCH 3         1907   H-7   OC 2 H 5     H   OCH 3         1908   H-7   OCF 3     H   OCH 3         1909   H-7   F   H   OC 2 H 5         1910   H-7   Cl   H   OC 2 H 5         1911   H-7   CH 3     H   OC 2 H 5         1912   H-7   CF 3     H   OC 2 H 5         1913   H-7   CN   H   OC 2 H 5         1914   H-7   OCH 3     H   OC 2 H 5         1915   H-7   OC 2 H 5     H   OC 2 H 5         1916   H-7   OCF 3     H   OC 2 H 5         1917   H-7   F   H   OCF 3         1918   H-7   Cl   H   OCF 3         1919   H-7   CH 3     H   OCF 3         1920   H-7   CF 3     H   OCF 3         1921   H-7   CN   H   OCF 3         1922   H-7   OCH 3     H   OCF 3         1923   H-7   OC 2 H 5     H   OCF 3         1924   H-7   OCF 3     H   OCF 3         1925   H-7   H   F   F       1926   H-7   H   Cl   F       1927   H-7   H   Br   F       1928   H-7   H   CH 3     F       1929   H-7   H   CF 3     F       1930   H-7   H   CN   F       1931   H-7   H   OCH 3     F       1932   H-7   H   OC 2 H 5     F       1933   H-7   H   OCF 3     F       1934   H-7   H   OCHF 2     F       1935   H-7   H   F   Cl       1936   H-7   H   Cl   Cl       1937   H-7   H   CH 3     Cl       1938   H-7   H   CF 3     Cl       1939   H-7   H   CN   Cl       1940   H-7   H   OCH 3     Cl       1941   H-7   H   OC 2 H 5     Cl       1942   H-7   H   OCF 3     Cl       1943   H-7   H   F   CH 3         1944   H-7   H   Cl   CH 3         1945   H-7   H   CH 3     CH 3         1946   H-7   H   CF 3     CH 3         1947   H-7   H   CN   CH 3         1948   H-7   H   OCH 3     CH 3         1949   H-7   H   OC 2 H 5     CH 3         1950   H-7   H   OCF 3     CH 3         1951   H-7   H   F   CF 3         1952   H-7   H   Cl   CF 3         1953   H-7   H   CH 3     CF 3         1954   H-7   H   CF 3     CF 3         1955   H-7   H   CN   CF 3         1956   H-7   H   OCH 3     CF 3         1957   H-7   H   OC 2 H 5     CF 3         1958   H-7   H   OCF 3     CF 3         1959   H-7   H   F   CN       1960   H-7   H   Cl   CN       1961   H-7   H   CH 3     CN       1962   H-7   H   CF 3     CN       1963   H-7   H   CN   CN       1964   H-7   H   OCH 3     CN       1965   H-7   H   OC 2 H 5     CN       1966   H-7   H   OCF 3     CN       1967   H-7   H   F   OCH 3         1968   H-7   H   Cl   OCH 3         1969   H-7   H   CH 3     OCH 3         1970   H-7   H   CF 3     OCH 3         1971   H-7   H   CN   OCH 3         1972   H-7   H   OCH 3     OCH 3         1973   H-7   H   OC 2 H 5     OCH 3         1974   H-7   H   OCF 3     OCH 3         1975   H-7   H   F   OC 2 H 5         1976   H-7   H   Cl   OC 2 H 5         1977   H-7   H   CH 3     OC 2 H 5         1978   H-7   H   CF 3     OC 2 H 5         1979   H-7   H   CN   OC 2 H 5         1980   H-7   H   OCH 3     OC 2 H 5         1981   H-7   H   OC 2 H 5     OC 2 H 5         1982   H-7   H   OCF 3     OC 2 H 5         1983   H-7   H   F   OCF 3         1984   H-7   H   Cl   OCF 3         1985   H-7   H   CH 3     OCF 3         1986   H-7   H   CF 3     OCF 3         1987   H-7   H   CN   OCF 3         1988   H-7   H   OCH 3     OCF 3         1989   H-7   H   OC 2 H 5     OCF 3         1990   H-7   H   OCF 3     OCF 3         1991   H-8   H   H   H       1992   H-8   F   H   H       1993   H-8   Cl   H   H       1994   H-8   CH 3     H   H       1995   H-8   CF 3     H   H       1996   H-8   CN   H   H       1997   H-8   OCH 3     H   H       1998   H-8   OC 2 H 5     H   H       1999   H-8   OCF 3     H   H       2000   H-8   H   F   H       2001   H-8   H   Cl   H       2002   H-8   H   CH 3     H       2003   H-8   H   CF 3     H       2004   H-8   H   CN   H       2005   H-8   H   OCH 3     H       2006   H-8   H   OC 2 H 5     H       2007   H-8   H   OCF 3     H       2008   H-8   H   H   F       2009   H-8   H   H   Cl       2010   H-8   H   H   CH 3         2011   H-8   H   H   CF 3         2012   H-8   H   H   CN       2013   H-8   H   H   OCH 3         2014   H-8   H   H   OC 2 H 5         2015   H-8   H   H   OCF 3         2016   H-8   F   F   H       2017   H-8   Cl   F   H       2018   H-8   CH 3     F   H       2019   H-8   CF 3     F   H       2020   H-8   CN   F   H       2021   H-8   OCH 3     F   H       2022   H-8   OC 2 H 5     F   H       2023   H-8   OCF 3     F   H       2024   H-8   F   Cl   H       2025   H-8   Cl   Cl   H       2026   H-8   CH 3     Cl   H       2027   H-8   CF 3     Cl   H       2028   H-8   CN   Cl   H       2029   H-8   OCH 3     Cl   H       2030   H-8   OC 2 H 5     Cl   H       2031   H-8   OCF 3     Cl   H       2032   H-8   F   CH 3     H       2033   H-8   Cl   CH 3     H       2034   H-8   CH 3     CH 3     H       2035   H-8   CF 3     CH 3     H       2036   H-8   CN   CH 3     H       2037   H-8   OCH 3     CH 3     H       2038   H-8   OC 2 H 5     CH 3     H       2039   H-8   OCF 3     CH 3     H       2040   H-8   F   CF 3     H       2041   H-8   Cl   CF 3     H       2042   H-8   CH 3     CF 3     H       2043   H-8   CF 3     CF 3     H       2044   H-8   CN   CF 3     H       2045   H-8   OCH 3     CF 3     H       2046   H-8   OC 2 H 5     CF 3     H       2047   H-8   OCF 3     CF 3     H       2048   H-8   F   CN   H       2049   H-8   Cl   CN   H       2050   H-8   CH 3     CN   H       2051   H-8   CF 3     CN   H       2052   H-8   CN   CN   H       2053   H-8   OCH 3     CN   H       2054   H-8   OC 2 H 5     CN   H       2055   H-8   OCF 3     CN   H       2056   H-8   F   OCH 3     H       2057   H-8   Cl   OCH 3     H       2058   H-8   CF 3     OCH 3     H       2059   H-8   CN   OCH 3     H       2060   H-8   OCH 3     OCH 3     H       2061   H-8   OC 2 H 5     OCH 3     H       2062   H-8   OCF 3     OCH 3     H       2063   H-8   F   OC 2 H 5     H       2064   H-8   Cl   OC 2 H 5     H       2065   H-8   CH 3     OC 2 H 5     H       2066   H-8   CF 3     OC 2 H 5     H       2067   H-8   CN   OC 2 H 5     H       2068   H-8   OCH 3     OC 2 H 5     H       2069   H-8   OC 2 H 5     OC 2 H 5     H       2070   H-8   OCF 3     OC 2 H 5     H       2071   H-8   F   OCF 3     H       2072   H-8   Cl   OCF 3     H       2073   H-8   CH 3     OCF 3     H       2074   H-8   CF 3     OCF 3     H       2075   H-8   CN   OCF 3     H       2076   H-8   OCH 3     OCF 3     H       2077   H-8   OC 2 H 5     OCF 3     H       2078   H-8   OCF 3     OCF 3     H       2079   H-8   F   H   F       2080   H-8   Cl   H   F       2081   H-8   CH 3     H   F       2082   H-8   CF 3     H   F       2083   H-8   CN   H   F       2084   H-8   OCH 3     H   F       2085   H-8   OC 2 H 5     H   F       2086   H-8   OCF 3     H   F       2087   H-8   F   H   Cl       2088   H-8   Cl   H   Cl       2089   H-8   CH 3     H   Cl       2090   H-8   CF 3     H   Cl       2091   H-8   CN   H   Cl       2092   H-8   OCH 3     H   Cl       2093   H-8   OC 2 H 5     H   Cl       2094   H-8   OCF 3     H   Cl       2095   H-8   F   H   CH 3         2096   H-8   Cl   H   CH 3         2097   H-8   CH 3     H   CH 3         2098   H-8   CF 3     H   CH 3         2099   H-8   CN   H   CH 3         2100   H-8   OCH 3     H   CH 3         2101   H-8   OC 2 H 5     H   CH 3         2102   H-8   OCF 3     H   CH 3         2103   H-8   F   H   CF 3         2104   H-8   Cl   H   CF 3         2105   H-8   CH 3     H   CF 3         2106   H-8   CF 3     H   CF 3         2107   H-8   CN   H   CF 3         2108   H-8   OCH 3     H   CF 3         2109   H-8   OC 2 H 5     H   CF 3         2110   H-8   OCF 3     H   CF 3         2111   H-8   F   H   CN       2112   H-8   Cl   H   CN       2113   H-8   CH 3     H   CN       2114   H-8   CF 3     H   CN       2115   H-8   CN   H   CN       2116   H-8   OCH 3     H   CN       2117   H-8   OC 2 H 5     H   CN       2118   H-8   OCF 3     H   CN       2119   H-8   F   H   OCH 3         2120   H-8   Cl   H   OCH 3         2121   H-8   CH 3     H   OCH 3         2122   H-8   CF 3     H   OCH 3         2123   H-8   CN   H   OCH 3         2124   H-8   OCH 3     H   OCH 3         2125   H-8   OC 2 H 5     H   OCH 3         2126   H-8   OCF 3     H   OCH 3         2127   H-8   F   H   OC 2 H 5         2128   H-8   Cl   H   OC 2 H 5         2129   H-8   CH 3     H   OC 2 H 5         2130   H-8   CF 3     H   OC 2 H 5         2131   H-8   CN   H   OC 2 H 5         2132   H-8   OCH 3     H   OC 2 H 5         2133   H-8   OC 2 H 5     H   OC 2 H 5         2134   H-8   OCF 3     H   OC 2 H 5         2135   H-8   F   H   OCF 3         2136   H-8   Cl   H   OCF 3         2137   H-8   CH 3     H   OCF 3         2138   H-8   CF 3     H   OCF 3         2139   H-8   CN   H   OCF 3         2140   H-8   OCH 3     H   OCF 3         2141   H-8   OC 2 H 5     H   OCF 3         2142   H-8   OCF 3     H   OCF 3         2143   H-8   H   F   F       2144   H-8   H   Cl   F       2145   H-8   H   CH 3     F       2146   H-8   H   CF 3     F       2147   H-8   H   CN   F       2148   H-8   H   OCH 3     F       2149   H-8   H   OC 2 H 5     F       2150   H-8   H   OCF 3     F       2151   H-8   H   F   Cl       2152   H-8   H   Cl   Cl       2153   H-8   H   CH 3     Cl       2154   H-8   H   CF 3     Cl       2155   H-8   H   CN   Cl       2156   H-8   H   OCH 3     Cl       2157   H-8   H   OC 2 H 5     Cl       2158   H-8   H   OCF 3     Cl       2159   H-8   H   F   CH 3         2160   H-8   H   Cl   CH 3         2161   H-8   H   CH 3     CH 3         2162   H-8   H   CF 3     CH 3         2163   H-8   H   CN   CH 3         2164   H-8   H   OCH 3     CH 3         2165   H-8   H   OC 2 H 5     CH 3         2166   H-8   H   OCF 3     CH 3         2167   H-8   H   F   CF 3         2168   H-8   H   Cl   CF 3         2169   H-8   H   CH 3     CF 3         2170   H-8   H   CF 3     CF 3         2171   H-8   H   CN   CF 3         2172   H-8   H   OCH 3     CF 3         2173   H-8   H   OC 2 H 5     CF 3         2174   H-8   H   OCF 3     CF 3         2175   H-8   H   F   CN       2176   H-8   H   Cl   CN       2177   H-8   H   CH 3     CN       2178   H-8   H   CF 3     CN       2179   H-8   H   CN   CN       2180   H-8   H   OCH 3     CN       2181   H-8   H   OC 2 H 5     CN       2182   H-8   H   OCF 3     CN       2183   H-8   H   F   OCH 3         2184   H-8   H   Cl   OCH 3         2185   H-8   H   CH 3     OCH 3         2186   H-8   H   CF 3     OCH 3         2187   H-8   H   CN   OCH 3         2188   H-8   H   OCH 3     OCH 3         2189   H-8   H   OC 2 H 5     OCH 3         2190   H-8   H   OCF 3     OCH 3         2191   H-8   H   F   OC 2 H 5         2192   H-8   H   Cl   OC 2 H 5         2193   H-8   H   CH 3     OC 2 H 5         2194   H-8   H   CF 3     OC 2 H 5         2195   H-8   H   CN   OC 2 H 5         2196   H-8   H   OCH 3     OC 2 H 5         2197   H-8   H   OC 2 H 5     OC 2 H 5         2198   H-8   H   OCF 3     OC 2 H 5         2199   H-8   H   F   OCF 3         2200   H-8   H   Cl   OCF 3         2201   H-8   H   CH 3     OCF 3         2202   H-8   H   CF 3     OCF 3         2203   H-8   H   CN   OCF 3         2204   H-8   H   OCH 3     OCF 3         2205   H-8   H   OC 2 H 5     OCF 3         2206   H-8   H   OCF 3     OCF 3         2207   H-9   CH 3     H   H       2208   H-9   CN   H   H       2209   H-9   OCH 3     H   H       2210   H-9   OC 2 H 5     H   H       2211   H-9   CH 3     F   H       2212   H-9   CN   F   H       2213   H-9   OCH 3     F   H       2214   H-9   OC 2 H 5     F   H       2215   H-9   CH 3     Cl   H       2216   H-9   CN   Cl   H       2217   H-9   OCH 3     Cl   H       2218   H-9   OC 2 H 5     Cl   H       2219   H-9   CH 3     CH 3     H       2220   H-9   CN   CH 3     H       2221   H-9   OCH 3     CH 3     H       2222   H-9   OC 2 H 5     CH 3     H       2223   H-9   CH 3     CF 3     H       2224   H-9   CN   CF 3     H       2225   H-9   OCH 3     CF 3     H       2226   H-9   OC 2 H 5     CF 3     H       2227   H-9   CH 3     CN   H       2228   H-9   CN   CN   H       2229   H-9   OCH 3     CN   H       2230   H-9   OC 2 H 5     CN   H       2231   H-9   CH 3     OCH 3     H       2232   H-9   CN   OCH 3     H       2233   H-9   OCH 3     OCH 3     H       2234   H-9   OC 2 H 5     OCH 3     H       2235   H-9   CH 3     OC 2 H 5     H       2236   H-9   CN   OC 2 H 5     H       2237   H-9   OCH 3     OC 2 H 5     H       2238   H-9   OC 2 H 5     OC 2 H 5     H       2239   H-9   CH 3     OCF 3     H       2240   H-9   CN   OCF 3     H       2241   H-9   OCH 3     OCF 3     H       2242   H-9   OC 2 H 5     OCF 3     H       2243   H-9   CH 3     H   F       2244   H-9   CN   H   F       2245   H-9   OCH 3     H   F       2246   H-9   OC 2 H 5     H   F       2247   H-9   CH 3     H   Cl       2248   H-9   CN   H   Cl       2249   H-9   OCH 3     H   Cl       2250   H-9   OC 2 H 5     H   Cl       2251   H-9   CH 3     H   CH 3         2252   H-9   CN   H   CH 3         2253   H-9   OCH 3     H   CH 3         2254   H-9   OC 2 H 5     H   CH 3         2255   H-9   CH 3     H   CF 3         2256   H-9   CN   H   CF 3         2257   H-9   OCH 3     H   CF 3         2258   H-9   OC 2 H 5     H   CF 3         2259   H-9   CH 3     H   CN       2260   H-9   CN   H   CN       2261   H-9   OCH 3     H   CN       2262   H-9   OC 2 H 5     H   CN       2263   H-9   CH 3     H   OCH 3         2264   H-9   CN   H   OCH 3         2265   H-9   OCH 3     H   OCH 3         2266   H-9   OC 2 H 5     H   OCH 3         2267   H-9   OCF 3     H   OCH 3         2268   H-9   CH 3     H   OC 2 H 5         2269   H-9   CN   H   OC 2 H 5         2270   H-9   OCH 3     H   OC 2 H 5         2271   H-9   OC 2 H 5     H   OC 2 H 5         2272   H-9   CH 3     H   OCF 3         2273   H-9   CN   H   OCF 3         2274   H-9   OCH 3     H   OCF 3         2275   H-9   OC 2 H 5     H   OCF 3         2276   H-9   CH 3     F   F       2277   H-9   CH 3     Cl   F       2278   H-9   CH 3     CH 3     F       2279   H-9   CH 3     CF 3     F       2280   H-9   CH 3     CN   F       2281   H-9   CH 3     OCH 3     F       2282   H-9   CH 3     OC 2 H 5     F       2283   H-9   CH 3     OCF 3     F       2284   H-9   CH 3     F   Cl       2285   H-9   CH 3     Cl   Cl       2286   H-9   CH 3     CH 3     Cl       2287   H-9   CH 3     CF 3     Cl       2288   H-9   CH 3     CN   Cl       2289   H-9   CH 3     OCH 3     Cl       2290   H-9   CH 3     OC 2 H 5     Cl       2291   H-9   CH 3     OCF 3     Cl       2292   H-9   CH 3     F   CH 3         2293   H-9   CH 3     Cl   CH 3         2294   H-9   CH 3     CH 3     CH 3         2295   H-9   CH 3     CF 3     CH 3         2296   H-9   CH 3     CN   CH 3         2297   H-9   CH 3     OCH 3     CH 3         2298   H-9   CH 3     OC 2 H 5     CH 3         2299   H-9   CH 3     OCF 3     CH 3         2300   H-9   CH 3     F   CF 3         2301   H-9   CH 3     Cl   CF 3         2302   H-9   CH 3     CH 3     CF 3         2303   H-9   CH 3     CF 3     CF 3         2304   H-9   CH 3     CN   CF 3         2305   H-9   CH 3     OCH 3     CF 3         2306   H-9   CH 3     OC 2 H 5     CF 3         2307   H-9   CH 3     OCF 3     CF 3         2308   H-9   CH 3     F   CN       2309   H-9   CH 3     Cl   CN       2310   H-9   CH 3     CH 3     CN       2311   H-9   CH 3     CF 3     CN       2312   H-9   CH 3     CN   CN       2313   H-9   CH 3     OCH 3     CN       2314   H-9   CH 3     OC 2 H 5     CN       2315   H-9   CH 3     OCF 3     CN       2316   H-9   CH 3     F   OCH 3         2317   H-9   CH 3     Cl   OCH 3         2318   H-9   CH 3     CH 3     OCH 3         2319   H-9   CH 3     CF 3     OCH 3         2320   H-9   CH 3     CN   OCH 3         2321   H-9   CH 3     OCH 3     OCH 3         2322   H-9   CH 3     OC 2 H 5     OCH 3         2323   H-9   CH 3     OCF 3     OCH 3         2324   H-9   CH 3     F   OC 2 H 5         2325   H-9   CH 3     Cl   OC 2 H 5         2326   H-9   CH 3     CH 3     OC 2 H 5         2327   H-9   CH 3     CF 3     OC 2 H 5         2328   H-9   CH 3     CN   OC 2 H 5         2329   H-9   CH 3     OCH 3     OC 2 H 5         2330   H-9   CH 3     OC 2 H 5     OC 2 H 5         2331   H-9   CH 3     OCF 3     OC 2 H 5         2332   H-9   CH 3     F   OCF 3         2333   H-9   CH 3     Cl   OCF 3         2334   H-9   CH 3     CH 3     OCF 3         2335   H-9   CH 3     CF 3     OCF 3         2336   H-9   CH 3     CN   OCF 3         2337   H-9   CH 3     OCH 3     OCF 3         2338   H-9   CH 3     OC 2 H 5     OCF 3         2339   H-9   CH 3     OCF 3     OCF 3         2340   H-10   CH 3     H   H       2341   H-10   CN   H   H       2342   H-10   OCH 3     H   H       2343   H-10   OC 2 H 5     H   H       2344   H-10   CH 3     F   H       2345   H-10   CN   F   H       2346   H-10   OCH 3     F   H       2347   H-10   OC 2 H 5     F   H       2348   H-10   CH 3     Cl   H       2349   H-10   CN   Cl   H       2350   H-10   OCH 3     Cl   H       2351   H-10   OC 2 H 5     Cl   H       2352   H-10   CH 3     CH 3     H       2353   H-10   CN   CH 3     H       2354   H-10   OCH 3     CH 3     H       2355   H-10   OC 2 H 5     CH 3     H       2356   H-10   CH 3     CF 3     H       2357   H-10   CN   CF 3     H       2358   H-10   OCH 3     CF 3     H       2359   H-10   OC 2 H 5     CF 3     H       2360   H-10   CH 3     CN   H       2361   H-10   CN   CN   H       2362   H-10   OCH 3     CN   H       2363   H-10   OC 2 H 5     CN   H       2364   H-10   CH 3     OCH 3     H       2365   H-10   CN   OCH 3     H       2366   H-10   OCH 3     OCH 3     H       2367   H-10   OC 2 H 5     OCH 3     H       2368   H-10   CH 3     OC 2 H 5     H       2369   H-10   CN   OC 2 H 5     H       2370   H-10   OCH 3     OC 2 H 5     H       2371   H-10   OC 2 H 5     OC 2 H 5     H       2372   H-10   CH 3     OCF 3     H       2373   H-10   CN   OCF 3     H       2374   H-10   OCH 3     OCF 3     H       2375   H-10   OC 2 H 5     OCF 3     H       2376   H-10   CH 3     H   F       2377   H-10   CN   H   F       2378   H-10   OCH 3     H   F       2379   H-10   OC 2 H 5     H   F       2380   H-10   CH 3     H   Cl       2381   H-10   CN   H   Cl       2382   H-10   OCH 3     H   Cl       2383   H-10   OC 2 H 5     H   Cl       2384   H-10   CH 3     H   CH 3         2385   H-10   CN   H   CH 3         2386   H-10   OCH 3     H   CH 3         2387   H-10   OC 2 H 5     H   CH 3         2388   H-10   CH 3     H   CF 3         2389   H-10   CN   H   CF 3         2390   H-10   OCH 3     H   CF 3         2391   H-10   OC 2 H 5     H   CF 3         2392   H-10   CH 3     H   CN       2393   H-10   CN   H   CN       2394   H-10   OCH 3     H   CN       2395   H-10   OC 2 H 5     H   CN       2396   H-10   CH 3     H   OCH 3         2397   H-10   CN   H   OCH 3         2398   H-10   OCH 3     H   OCH 3         2399   H-10   OC 2 H 5     H   OCH 3         2400   H-10   OCF 3     H   OCH 3         2401   H-10   CH 3     H   OC 2 H 5         2402   H-10   CN   H   OC 2 H 5         2403   H-10   OCH 3     H   OC 2 H 5         2404   H-10   OC 2 H 5     H   OC 2 H 5         2405   H-10   CH 3     H   OCF 3         2406   H-10   CN   H   OCF 3         2407   H-10   OCH 3     H   OCF 3         2408   H-10   OC 2 H 5     H   OCF 3         2409   H-10   CH 3     F   F       2410   H-10   CH 3     Cl   F       2411   H-10   CH 3     CH 3     F       2412   H-10   CH 3     CF 3     F       2413   H-10   CH 3     CN   F       2414   H-10   CH 3     OCH 3     F       2415   H-10   CH 3     OC 2 H 5     F       2416   H-10   CH 3     OCF 3     F       2417   H-10   CH 3     F   Cl       2418   H-10   CH 3     Cl   Cl       2419   H-10   CH 3     CH 3     Cl       2420   H-10   CH 3     CF 3     Cl       2421   H-10   CH 3     CN   Cl       2422   H-10   CH 3     OCH 3     Cl       2423   H-10   CH 3     OC 2 H 5     Cl       2424   H-10   CH 3     OCF 3     Cl       2425   H-10   CH 3     F   CH 3         2426   H-10   CH 3     Cl   CH 3         2427   H-10   CH 3     CH 3     CH 3         2428   H-10   CH 3     CF 3     CH 3         2429   H-10   CH 3     CN   CH 3         2430   H-10   CH 3     OCH 3     CH 3         2431   H-10   CH 3     OC 2 H 5     CH 3         2432   H-10   CH 3     OCF 3     CH 3         2433   H-10   CH 3     F   CF 3         2434   H-10   CH 3     Cl   CF 3         2435   H-10   CH 3     CH 3     CF 3         2436   H-10   CH 3     CF 3     CF 3         2437   H-10   CH 3     CN   CF 3         2438   H-10   CH 3     OCH 3     CF 3         2439   H-10   CH 3     OC 2 H 5     CF 3         2440   H-10   CH 3     OCF 3     CF 3         2441   H-10   CH 3     F   CN       2442   H-10   CH 3     Cl   CN       2443   H-10   CH 3     CH 3     CN       2444   H-10   CH 3     CF 3     CN       2445   H-10   CH 3     CN   CN       2446   H-10   CH 3     OCH 3     CN       2447   H-10   CH 3     OC 2 H 5     CN       2448   H-10   CH 3     OCF 3     CN       2449   H-10   CH 3     F   OCH 3         2450   H-10   CH 3     Cl   OCH 3         2451   H-10   CH 3     CH 3     OCH 3         2452   H-10   CH 3     CF 3     OCH 3         2453   H-10   CH 3     CN   OCH 3         2454   H-10   CH 3     OCH 3     OCH 3         2455   H-10   CH 3     OC 2 H 5     OCH 3         2456   H-10   CH 3     OCF 3     OCH 3         2457   H-10   CH 3     F   OC 2 H 5         2458   H-10   CH 3     Cl   OC 2 H 5         2459   H-10   CH 3     CH 3     OC 2 H 5         2460   H-10   CH 3     CF 3     OC 2 H 5         2461   H-10   CH 3     CN   OC 2 H 5         2462   H-10   CH 3     OCH 3     OC 2 H 5         2463   H-10   CH 3     OC 2 H 5     OC 2 H 5         2464   H-10   CH 3     OCF 3     OC 2 H 5         2465   H-10   CH 3     F   OCF 3         2466   H-10   CH 3     Cl   OCF 3         2467   H-10   CH 3     CH 3     OCF 3         2468   H-10   CH 3     CF 3     OCF 3         2469   H-10   CH 3     CN   OCF 3         2470   H-10   CH 3     OCH 3     OCF 3         2471   H-10   CH 3     OC 2 H 5     OCF 3         2472   H-10   CH 3     OCF 3     OCF 3         2473   H-11   H   H       2474   H-11   F   H       2475   H-11   Cl   H       2476   H-11   CH 3     H       2477   H-11   CF 3     H       2478   H-11   CN   H       2479   H-11   OCH 3     H       2480   H-11   OC 2 H 5     H       2481   H-11   OCF 3     H       2482   H-11   H   F       2483   H-11   H   Cl       2484   H-11   H   CH 3         2485   H-11   H   CF 3         2486   H-11   H   CN       2487   H-11   H   OCH 3         2488   H-11   H   OC 2 H 5         2489   H-11   H   OCF 3         2490   H-11   F   F       2491   H-11   Cl   F       2492   H-11   CH 3     F       2493   H-11   CF 3     F       2494   H-11   CN   F       2495   H-11   OCH 3     F       2496   H-11   OC 2 H 5     F       2497   H-11   OCF 3     F       2498   H-11   F   Cl       2499   H-11   Cl   Cl       2500   H-11   CH 3     Cl       2501   H-11   CF 3     Cl       2502   H-11   CN   Cl       2503   H-11   OCH 3     Cl       2504   H-11   OC 2 H 5     Cl       2505   H-11   OCF 3     Cl       2506   H-11   F   CH 3         2507   H-11   Cl   CH 3         2508   H-11   Br   CH 3         2509   H-11   CH 3     CH 3         2510   H-11   CF 3     CH 3         2511   H-11   CN   CH 3         2512   H-11   OCH 3     CH 3         2513   H-11   OC 2 H 5     CH 3         2514   H-11   OCF 3     CH 3         2515   H-11   Cl   CF 3         2516   H-11   CH 3     CF 3         2517   H-11   CF 3     CF 3         2518   H-11   CN   CF 3         2519   H-11   OCH 3     CF 3         2520   H-11   OC 2 H 5     CF 3         2521   H-11   OCF 3     CF 3         2522   H-11   F   CN       2523   H-11   Cl   CN       2524   H-11   CH 3     CN       2525   H-11   CF 3     CN       2526   H-11   CN   CN       2527   H-11   OCH 3     CN       2528   H-11   OC 2 H 5     CN       2529   H-11   OCF 3     CN       2530   H-11   F   OCH 3         2531   H-11   Cl   OCH 3         2532   H-11   CH 3     OCH 3         2533   H-11   CF 3     OCH 3         2534   H-11   CN   OCH 3         2535   H-11   OCH 3     OCH 3         2536   H-11   OC 2 H 5     OCH 3         2537   H-11   OCF 3     OCH 3         2538   H-11   F   OC 2 H 5         2539   H-11   Cl   OC 2 H 5         2540   H-11   CH 3     OC 2 H 5         2541   H-11   CF 3     OC 2 H 5         2542   H-11   CN   OC 2 H 5         2543   H-11   OCH 3     OC 2 H 5         2544   H-11   OC 2 H 5     OC 2 H 5         2545   H-11   OCF 3     OC 2 H 5         2546   H-11   F   OCF 3         2547   H-11   Cl   OCF 3         2548   H-11   Br   OCF 3         2549   H-11   CH 3     OCF 3         2550   H-11   CF 3     OCF 3         2551   H-11   CN   OCF 3         2552   H-11   OCH 3     OCF 3         2553   H-11   OC 2 H 5     OCF 3         2554   H-11   OCF 3     OCF 3         2555   H-12   H   H       2556   H-12   F   H       2557   H-12   Cl   H       2558   H-12   CH 3     H       2559   H-12   CF 3     H       2560   H-12   CN   H       2561   H-12   OCH 3     H       2562   H-12   OC 2 H 5     H       2563   H-12   OCF 3     H       2564   H-12   H   F       2565   H-12   H   Cl       2566   H-12   H   CH 3         2567   H-12   H   CF 3         2568   H-12   H   CN       2569   H-12   H   OCH 3         2570   H-12   H   OC 2 H 5         2571   H-12   H   OCF 3         2572   H-12   F   F       2573   H-12   Cl   F       2574   H-12   CH 3     F       2575   H-12   CF 3     F       2576   H-12   CN   F       2577   H-12   OCH 3     F       2578   H-12   OC 2 H 5     F       2579   H-12   OCF 3     F       2580   H-12   F   Cl       2581   H-12   Cl   Cl       2582   H-12   CH 3     Cl       2583   H-12   CF 3     Cl       2584   H-12   CN   Cl       2585   H-12   OCH 3     Cl       2586   H-12   OC 2 H 5     Cl       2587   H-12   OCF 3     Cl       2588   H-12   F   CH 3         2589   H-12   Cl   CH 3         2590   H-12   CH 3     CH 3         2591   H-12   CF 3     CH 3         2592   H-12   CN   CH 3         2593   H-12   OCH 3     CH 3         2594   H-12   OC 2 H 5     CH 3         2595   H-12   OCF 3     CH 3         2596   H-12   F   CF 3         2597   H-12   Cl   CF 3         2598   H-12   CH 3     CF 3         2599   H-12   CF 3     CF 3         2600   H-12   CN   CF 3         2601   H-12   OCH 3     CF 3         2602   H-12   OC 2 H 5     CF 3         2603   H-12   OCF 3     CF 3         2604   H-12   F   CN       2605   H-12   Cl   CN       2606   H-12   CH 3     CN       2607   H-12   CF 3     CN       2608   H-12   CN   CN       2609   H-12   OCH 3     CN       2610   H-12   OC 2 H 5     CN       2611   H-12   OCF 3     CN       2612   H-12   F   OCH 3         2613   H-12   Cl   OCH 3         2614   H-12   CH 3     OCH 3         2615   H-12   CF 3     OCH 3         2616   H-12   CN   OCH 3         2617   H-12   OCH 3     OCH 3         2618   H-12   OC 2 H 5     OCH 3         2619   H-12   OCF 3     OCH 3         2620   H-12   F   OC 2 H 5         2621   H-12   Cl   OC 2 H 5         2622   H-12   CH 3     OC 2 H 5         2623   H-12   CF 3     OC 2 H 5         2624   H-12   CN   OC 2 H 5         2625   H-12   OCH 3     OC 2 H 5         2626   H-12   OC 2 H 5     OC 2 H 5         2627   H-12   OCF 3     OC 2 H 5         2628   H-12   F   OCF 3         2629   H-12   Cl   OCF 3         2630   H-12   CH 3     OCF 3         2631   H-12   CF 3     OCF 3         2632   H-12   CN   OCF 3         2633   H-12   OCH 3     OCF 3         2634   H-12   OC 2 H 5     OCF 3         2635   H-12   OCF 3     OCF 3 ,                    
wherein Het is selected from the radicals H-1 to H-12 as described herein.
 
     The compounds I and the compositions according to the invention, respectively, are suitable as fungicides. They are distinguished by an outstanding effectiveness against a broad spectrum of phytopathogenic fungi, including soil-borne fungi, which derive especially from the classes of the Plasmodiophoromycetes, Peronosporomycetes (syn. Oomycetes), Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes (syn. Fungi imperfecti). Some are systemically effective and they can be used in crop protection as foliar fungicides, fungicides for seed dressing and soil fungicides. Moreover, they are suitable for controlling harmful fungi, which inter alia occur in wood or roots of plants. 
     The compounds I and the compositions according to the invention are particularly important in the control of a multitude of phytopathogenic fungi on various cultivated plants, such as cereals, e.g. wheat, rye, barley, triticale, oats or rice; beet, e.g. sugar beet or fodder beet; fruits, such as pomes, stone fruits or soft fruits, e.g. apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, blackberries or gooseberries; leguminous plants, such as lentils, peas, alfalfa or soybeans; oil plants, such as rape, mustard, olives, sunflowers, coconut, cocoa beans, castor oil plants, oil palms, ground nuts or soybeans; cucurbits, such as squashes, cucumber or melons; fiber plants, such as cotton, flax, hemp or jute; citrus fruit, such as oranges, lemons, grapefruits or mandarins; vegetables, such as spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, cucurbits or paprika; lauraceous plants, such as avocados, cinnamon or camphor; energy and raw material plants, such as corn, soybean, rape, sugar cane or oil palm; corn; tobacco; nuts; coffee; tea; bananas; vines (table grapes and grape juice grape vines); hop; turf; natural rubber plants or ornamental and forestry plants, such as flowers, shrubs, broad-leaved trees or evergreens, e.g. conifers; and on the plant propagation material, such as seeds, and the crop material of these plants. 
     Preferably, compounds I and compositions thereof, respectively are used for controlling a multitude of fungi on field crops, such as potatoes sugar beets, tobacco, wheat, rye, barley, oats, rice, corn, cotton, soybeans, rape, legumes, sunflowers, coffee or sugar cane; fruits; vines; ornamentals; or vegetables, such as cucumbers, tomatoes, beans or squashes. 
     The term “plant propagation material” is to be understood to denote all the generative parts of the plant such as seeds and vegetative plant material such as cuttings and tubers (e.g. potatoes), which can be used for the multiplication of the plant. This includes seeds, roots, fruits, tubers, bulbs, rhizomes, shoots, sprouts and other parts of plants, including seedlings and young plants, which are to be transplanted after germination or after emergence from soil. These young plants may also be protected before transplantation by a total or partial treatment by immersion or pouring. 
     Preferably, treatment of plant propagation materials with compounds I and compositions thereof, respectively, is used for controlling a multitude of fungi on cereals, such as wheat, rye, barley and oats; rice, corn, cotton and soybeans. 
     The term “cultivated plants” is to be understood as including plants which have been modified by breeding, mutagenesis or genetic engineering including but not limiting to agricultural biotech products on the market or in development (cf. http://www.bio.org/speeches/pubs/er/agri_products.asp). Genetically modified plants are plants, which genetic material has been so modified by the use of recombinant DNA techniques that under natural circumstances cannot readily be obtained by cross breeding, mutations or natural recombination. Typically, one or more genes have been integrated into the genetic material of a genetically modified plant in order to improve certain properties of the plant. Such genetic modifications also include but are not limited to targeted post-translational modification of protein(s), oligo- or polypeptides e.g. by glycosylation or polymer additions such as prenylated, acetylated or farnesylated moieties or PEG moieties. 
     The compounds I and compositions thereof, respectively, are particularly suitable for controlling the following plant diseases: 
       Alternaria  spp. ( Alternaria  leaf spot) on vegetables, rape ( A. brassicola  or brassicae), sugar beets ( A. tenuis ), fruits, rice, soybeans, potatoes (e.g.  A. solani  or  A. alternate ), tomatoes (e.g.  A. solani  or  A. alternate ) and wheat;  Bipolaris  and  Drechslera  spp. (teleomorph:  Cochliobolus  spp.), e.g. Southern leaf blight ( D. maydis ) or Northern leaf blight ( B. zeicola ) on corn, e.g. spot blotch ( B. sorokiniana ) on cereals and e.g.  B. oryzae  on rice and turfs; Blumeria (formerly  Erysiphe ) graminis (powdery mildew) on cereals (e.g. on wheat or barley);  Botrytis cinerea  (teleomorph:  Botryotinia fuckeliana : grey mold) on fruits and berries (e.g. strawberries), vegetables (e.g. lettuce, carrots, celery and cabbages), rape, flowers, vines, forestry plants and wheat;  Drechslera  (syn.  Helminthosporium , teleomorph:  Pyrenophora ) spp. on corn, cereals, such as barley (e.g.  D. teres , net blotch) and wheat (e.g.  D. tritici - repentis : tan spot), rice and turf; Esca (dieback, apoplexy) on vines;  Erysiphe  spp. (powdery mildew) on sugar beets ( E. betae ), vegetables (e.g. E. pisi), such as cucurbits (e.g.  E. cichoracearum ), cabbages, rape (e.g.  E. cruciferarum );  Fusarium  (teleomorph:  Gibberella ) spp. (wilt, root or stem rot) on various plants, such as  F. graminearum  or  F. culmorum  (root rot, scab or head blight) on cereals (e.g. wheat or barley),  F. oxysporum  on tomatoes,  F. solani  on soybeans and  F. verticillioides  on corn;  Gaeumannomyces graminis  (take-all) on cereals (e.g. wheat or barley) and corn;  Gibberella  spp. on cereals (e.g.  G. zeae ) and rice (e.g.  G. fujikuroi : Bakanae disease);  Guignardia bidwellii  (black rot) on vines; Microdochium (syn.  Fusarium ) nivale (pink snow mold) on cereals (e.g. wheat or barley);  Monilinia  spp., e.g.  M. laxa, M. fructicola  and  M. fructigena  (bloom and twig blight, brown rot) on stone fruits and other rosaceous plants;  Mycosphaerella  spp. on cereals, bananas, soft fruits and ground nuts, such as e.g.  M. graminicola  (anamorph:  Septoria tritici, Septoria  blotch) on wheat or  M. fijiensis  (black Sigatoka disease) on bananas;  Peronospora  spp. (downy mildew) on cabbage (e.g.  P. brassicae ), rape (e.g.  P. parasitica ), onions (e.g.  P. destructor ), tobacco ( P. tabacina ) and soybeans (e.g.  P. manshurica );  Phakopsora pachyrhizi  and  P. meibomiae  (soybean rust) on soybeans;  Phytophthora  spp. (wilt, root, leaf, fruit and stem root) on various plants, such as paprika and cucurbits (e.g.  P. capsici ), soybeans (e.g.  P. megasperma , syn.  P. sojae ), potatoes and tomatoes (e.g.  P. infestans : late blight);  Plasmopara  spp., e.g.  P. viticola  (grapevine downy mildew) on vines;  Puccinia  spp. (rusts) on various plants, e.g.  P. triticina  (brown or leaf rust),  P. striiformis  (stripe or yellow rust),  P. hordei  (dwarf rust),  P. graminis  (stem or black rust) or  P. recondita  (brown or leaf rust) on cereals, such as e.g. wheat, barley or rye, and asparagus (e.g.  P. asparagi );  Pyrenophora  (anamorph:  Drechslera ) tritici-repentis (tan spot) on wheat or  P. teres  (net blotch) on barley;  Pyricularia  spp., e.g.  P. oryzae  (teleomorph:  Magnaporthe grisea , rice blast) on rice and  P. grisea  on turf and cereals;  Pythium  spp. (damping-off) on turf, rice, corn, wheat, cotton, rape, sunflowers, soybeans, sugar beets, vegetables and various other plants (e.g.  P. ultimum  or  P. aphanidermatum );  Rhizoctonia  spp. on cotton, rice, potatoes, turf, corn, rape, potatoes, sugar beets, vegetables and various other plants, e.g.  R. solani  (root and stem rot) on soybeans,  R. solani  (sheath blight) on rice or  R. cerealis  (Rhizoctonia spring blight) on wheat or barley;  Rhynchosporium secalis  (scald) on barley, rye and triticale;  Septoria  spp. on various plants, e.g.  S. glycines  (brown spot) on soybeans,  S. tritici  (Septoria blotch) on wheat and S. (syn.  Stagonospora ) nodorum (Stagonospora blotch) on cereals;  Uncinula  (syn.  Erysiphe )  necator  (powdery mildew, anamorph: Oidium tuckeri) on vines;  Stagonospora  spp. on cereals, e.g.  S. nodorum  (Stagonospora blotch, teleomorph:  Leptosphaeria  [syn.  Phaeosphaeria] nodorum ) on wheat;  Venturia  spp. (scab) on apples (e.g.  V. inaequalis ) and pears. 
     The compounds I and compositions thereof, respectively, are also suitable for controlling harmful fungi in the protection of stored products or harvest and in the protection of materials. The term “protection of materials” is to be understood to denote the protection of technical and non-living materials, such as adhesives, glues, wood, paper and paperboard, textiles, leather, paint dispersions, plastics, coiling lubricants, fiber or fabrics, against the infestation and destruction by harmful microorganisms, such as fungi and bacteria. 
     The compounds I and compositions thereof, respectively, may be used for improving the health of a plant. The invention also relates to a method for improving plant health by treating a plant, its propagation material and/or the locus where the plant is growing or is to grow with an effective amount of compounds I and compositions thereof, respectively. 
     The term “plant health” is to be understood to denote a condition of the plant and/or its products which is determined by several indicators alone or in combination with each other such as yield (e.g. increased biomass and/or increased content of valuable ingredients), plant vigor (e.g. improved plant growth and/or greener leaves (“greening effect”)), quality (e.g. improved content or composition of certain ingredients) and tolerance to abiotic and/or biotic stress. The above identified indicators for the health condition of a plant may be interdependent or may result from each other. 
     The compounds of formula I can be present in different crystal modifications whose biological activity may differ. They are likewise subject matter of the present invention. 
     The compounds I are employed as such or in form of compositions by treating the fungi or the plants, plant propagation materials, such as seeds, soil, surfaces, materials or rooms to be protected from fungal attack with a fungicidally effective amount of the active substances. The application can be carried out both before and after the infection of the plants, plant propagation materials, such as seeds, soil, surfaces, materials or rooms by the fungi. 
     The invention also relates to agrochemical compositions comprising a solvent or solid carrier and at least one compound I and to the use for controlling harmful fungi. 
     An agrochemical composition comprises a fungicidally effective amount of a compound I. The term “effective amount” denotes an amount of the composition or of the compounds I, which is sufficient for controlling harmful fungi on cultivated plants or in the protection of materials and which does not result in a substantial damage to the treated plants. Such an amount can vary in a broad range and is dependent on various factors, such as the fungal species to be controlled, the treated cultivated plant or material, the climatic conditions and the specific compound I used. 
     The compounds I, their N-oxides and salts can be converted into customary types of agrochemical compositions, e.g. solutions, emulsions, suspensions, dusts, powders, pastes and granules. The composition type depends on the particular intended purpose; in each case, it should ensure a fine and uniform distribution of the compound according to the invention. 
     Examples for composition types are suspensions (SC, OD, FS), emulsifiable concentrates (EC), emulsions (EW, EO, ES), pastes, pastilles, wettable powders or dusts (WP, SP, SS, WS, DP, DS) or granules (GR, FG, GG, MG), which can be water-soluble or wettable, as well as gel formulations for the treatment of plant propagation materials such as seeds (GF). 
     Usually the composition types (e.g. SC, OD, FS, EC, WG, SG, WP, SP, SS, WS, GF) are employed diluted. Composition types such as DP, DS, GR, FG, GG and MG are usually used undiluted. 
     The compositions are prepared in a known manner (cf. U.S. Pat. No. 3,060,084, EP-A 707 445 (for liquid concentrates), Browning: “Agglomeration”, Chemical Engineering, Dec. 4, 1967, 147-48, Perry&#39;s Chemical Engineer&#39;s Handbook, 4th Ed., McGraw-Hill, New York, 1963, S. 8-57 and ff. WO 91/13546, U.S. Pat. No. 4,172,714, U.S. Pat. No. 4,144,050, U.S. Pat. No. 3,920,442, U.S. Pat. No. 5,180,587, U.S. Pat. No. 5,232,701, U.S. Pat. No. 5,208,030, GB 2,095,558, U.S. Pat. No. 3,299,566, Klingman: Weed Control as a Science (J. Wiley &amp; Sons, New York, 1961), Hance et al.: Weed Control Handbook (8th Ed., Blackwell Scientific, Oxford, 1989) and Mollet, H. and Grubemann, A.: Formulation technology (Wiley VCH Verlag, Weinheim, 2001). 
     The agrochemical compositions may also comprise auxiliaries which are customary in agrochemical compositions. The auxiliaries used depend on the particular application form and active substance, respectively. 
     Examples for suitable auxiliaries are solvents, solid carriers, dispersants or emulsifiers (such as further solubilizers, protective colloids, surfactants and adhesion agents), organic and anorganic thickeners, bactericides, anti-freezing agents, anti-foaming agents, if appropriate colorants and tackifiers or binders (e.g. for seed treatment formulations). 
     Powders, materials for spreading and dusts can be prepared by mixing or concomitantly grinding the compounds I and, if appropriate, further active substances, with at least one solid carrier. 
     Granules, e.g. coated granules, impregnated granules and homogeneous granules, can be prepared by binding the active substances to solid carriers. 
     The agrochemical compositions generally comprise between 0.01 and 95%, preferably between 0.1 and 90%, most preferably between 0.5 and 90%, by weight of active substance. The active substances are employed in a purity of from 90% to 100%, preferably from 95% to 100% (according to NMR spectrum). 
     Water-soluble concentrates (LS), flowable concentrates (FS), powders for dry treatment (DS), water-dispersible powders for slurry treatment (WS), water-soluble powders (SS), emulsions (ES) emulsifiable concentrates (EC) and gels (GF) are usually employed for the purposes of treatment of plant propagation materials, particularly seeds. These compositions can be applied to plant propagation materials, particularly seeds, diluted or undiluted. The compositions in question give, after two-to-tenfold dilution, active substance concentrations of from 0.01 to 60% by weight, preferably from 0.1 to 40% by weight, in the ready-to-use preparations. 
     In a preferred embodiment, a suspension-type (FS) composition is used for seed treatment. Typcially, a FS composition may comprise 1-800 g/l of active substance, 1-200 g/l Surfactant, 0 to 200 g/l antifreezing agent, 0 to 400 g/l of binder, 0 to 200 g/l of a pigment and up to 1 liter of a solvent, preferably water. 
     Aqueous application forms can be prepared from emulsion concentrates, pastes or wettable powders (sprayable powders, oil dispersions) by adding water. To prepare emulsions, pastes or oil dispersions, the substances, as such or dissolved in an oil or solvent, can be homogenized in water by means of a wetter, tackifier, dispersant or emulsifier. Alternatively, it is possible to prepare concentrates composed of active substance, wetter, tackifier, dispersant or emulsifier and, if appropriate, solvent or oil, and such concentrates are suitable for dilution with water. 
     The active substance concentrations in the ready-to-use preparations can be varied within relatively wide ranges. In general, they are from 0.0001 to 10%, preferably from 0.001 to 1% by weight of active substance. 
     The active substances may also be used successfully in the ultra-low-volume process (ULV), it being possible to apply compositions comprising over 95% by weight of active substance, or even to apply the active substance without additives. 
     When employed in plant protection, the amounts of active substances applied are, depending on the kind of effect desired, from 0.001 to 2 kg per ha, preferably from 0.005 to 2 kg per ha, more preferably from 0.05 to 0.9 kg per ha, in particular from 0.1 to 0.75 kg per ha. 
     In treatment of plant propagation materials such as seeds, e.g. by dusting, coating or drenching seed, amounts of active substance of from 0.1 to 1000 g, preferably from 1 to 1000 g, more preferably from 1 to 100 g and most preferably from 5 to 100 g, per 100 kilogram of plant propagation material (preferably seed) are generally required. 
     When used in the protection of materials or stored products, the amount of active substance applied depends on the kind of application area and on the desired effect. Amounts customarily applied in the protection of materials are, e.g., 0.001 g to 2 kg, preferably 0.005 g to 1 kg, of active substance per cubic meter of treated material. 
     Various types of oils, wetters, adjuvants, herbicides, bactericides, other fungicides and/or pesticides may be added to the active substances or the compositions comprising them, if appropriate not until immediately prior to use (tank mix). These agents can be admixed with the compositions according to the invention in a weight ratio of 1:100 to 100:1, preferably 1:10 to 10:1. 
     The compositions according to the invention can, in the use form as fungicides, also be present together with other active substances, e.g. with herbicides, insecticides, growth regulators, fungicides or else with fertilizers, as pre-mix or, if appropriate, not until immediately prior to use (tank mix). 
     Mixing the compounds I or the compositions comprising them in the use form as fungicides with other fungicides results in many cases in an expansion of the fungicidal spectrum of activity being obtained or in a prevention of fungicide resistance development. Furthermore, in many cases, synergistic effects are obtained. 
     The following list of active substances, in conjunction with which the compounds according to the invention can be used, is intended to illustrate the possible combinations but does not limit them: 
     A) strobilurins
         azoxystrobin, dimoxystrobin, enestroburin, fluoxastrobin, kresoxim-methyl, metominostrobin, orysastrobin, picoxystrobin, pyraclostrobin, pyribencarb, trifloxystrobin, 2-(2-(6-(3-chloro-2-methyl-phenoxy)-5-fluoro-pyrimidin-4-yloxy)-phenyl)-2-methoxyimino-N-methyl-acetamide, 3-methoxy-2-(2-(N-(4-methoxy-phenyl)-cyclopropane-carboximidoylsulfanylmethyl)-phenyl)-acrylic acid methyl ester, methyl (2-chloro-5-[1-(3-methylbenzyloxyimino)ethyl]benzyl)carbamate and 2-(2-(3-(2,6-di-chlorophenyl)-1-methyl-allylideneaminooxymethyl)-phenyl)-2-methoxyimino-N-methyl-acetamide;
 
B) carboxamides
   carboxanilides: benalaxyl, benalaxyl-M, benodanil, bixafen, boscalid, carboxin, fenfuram, fenhexamid, flutolanil, furametpyr, isopyrazam, isotianil, kiralaxyl, mepronil, metalaxyl, metalaxyl-M (mefenoxam), ofurace, oxadixyl, oxycarboxin, penthiopyrad, sedaxane, tecloftalam, thifluzamide, tiadinil, 2-amino-4-methyl-thiazole-5-carboxanilide, 2-chloro-N-(1,1,3-trimethyl-indan-4-yl)-nicotinamide, N-(3′,4′,5′-trifluorobiphenyl-2-yl)-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamide, N-(4′-trifluoromethylthiobiphenyl-2-yl)-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamide, N-(2-(1,3-dimethyl-butyl)-phenyl)-1,3-dimethyl-5-fluoro-1H-pyrazole-4-carboxamide and N-(2-(1,3,3-trimethyl-butyl)-phenyl)-1,3-dimethyl-5-fluoro-1H-pyrazole-4-carboxamide;   carboxylic morpholides: dimethomorph, flumorph, pyrimorph;   benzoic acid amides: flumetover, fluopicolide, fluopyram, zoxamide, N-(3-Ethyl-3,5,5-trimethyl-cyclohexyl)-3-formylamino-2-hydroxy-benzamide;   other carboxamides: carpropamid, dicyclomet, mandiproamid, oxytetracyclin, silthiofarm and N-(6-methoxy-pyridin-3-yl)cyclopropanecarboxylic acid amide;
 
C) azoles
   triazoles: azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, oxpoconazole, paclobutrazole, penconazole, propiconazole, prothioconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole, 1-(4-chloro-phenyl)-2-([1,2,4]triazol-1-yl)-cycloheptanol;   imidazoles: cyazofamid, imazalil, pefurazoate, prochloraz, triflumizol;   benzimidazoles: benomyl, carbendazim, fuberidazole, thiabendazole;   others: ethaboxam, etridiazole, hymexazole and 2-(4-chloro-phenyl)-N-[4-(3,4-dimethoxy-phenyl)-isoxazol-5-yl]-2-prop-2-ynyloxy-acetamide;
 
D) heterocyclic compounds
   pyridines: fluazinam, pyrifenox, 3-[5-(4-chloro-phenyl)-2,3-dimethyl-isoxazolidin-3-yl]-pyridine, 3-[5-(4-methyl-phenyl)-2,3-dimethyl-isoxazolidin-3-yl]-pyridine, 2,3,5,6-tetra-chloro-4-methanesulfonyl-pyridine, 3,4,5-trichloropyridine-2,6-di-carbonitrile, N-(1-(5-bromo-3-chloro-pyridin-2-yl)-ethyl)-2,4-dichloronicotinamide, N-[(5-bromo-3-chloro-pyridin-2-yl)-methyl]-2,4-dichloro-nicotinamide;   pyrimidines: bupirimate, cyprodinil, diflumetorim, fenarimol, ferimzone, mepanipyrim, nitrapyrin, nuarimol, pyrimethanil;   piperazines: triforine;   pyrroles: fenpiclonil, fludioxonil;   morpholines: aldimorph, dodemorph, dodemorph-acetate, fenpropimorph, tridemorph;   piperidines: fenpropidin;   dicarboximides: fluoroimid, iprodione, procymidone, vinclozolin;   non-aromatic 5-membered heterocycles: famoxadone, fenamidone, flutianil, octhilinone, probenazole, 5-amino-2-isopropyl-3-oxo-4-ortho-tolyl-2,3-dihydro-pyrazole-1-carbothioic acid S-allyl ester;   others: acibenzolar-5-methyl, amisulbrom, anilazin, blasticidin-S, captafol, captan, chinomethionat, dazomet, debacarb, diclomezine, difenzoquat, difenzoquat-methylsulfate, fenoxanil, Folpet, oxolinic acid, piperalin, proquinazid, pyroquilon, quinoxyfen, triazoxide, tricyclazole, 2-butoxy-6-iodo-3-propylchromen-4-one, 5-chloro-1-(4,6-dimethoxy-pyrimidin-2-yl)-2-methyl-1H-benzoimidazole, 5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine and 5-ethyl-6-octyl-[1,2,4]triazolo[1,5-a]pyrimidine-7-ylamine;
 
E) carbamates
   thio- and dithiocarbamates: ferbam, mancozeb, maneb, metam, methasulphocarb, metiram, propineb, thiram, zineb, ziram;   carbamates: benthiavalicarb, diethofencarb, iprovalicarb, propamocarb, propamocarb hydrochlorid, valiphenal and N-(1-(1-(4-cyano-phenyl)ethanesulfonyl)-but-2-yl) carbamic acid-(4-fluorophenyl) ester;
 
F) other active substances
   guanidines: guanidine, dodine, dodine free base, guazatine, guazatine-acetate, iminoctadine, iminoctadine-triacetate, iminoctadine-tris(albesilate);   antibiotics: kasugamycin, kasugamycin hydrochloride-hydrate, streptomycin, polyoxine, validamycin A;   nitrophenyl derivates: binapacryl, dinobuton, dinocap, nitrthal-isopropyl, tecnazen, organometal compounds: fentin salts, such as fentin-acetate, fentin chloride or fentin hydroxide;   sulfur-containing heterocyclyl compounds: dithianon, isoprothiolane;   organophosphorus compounds: edifenphos, fosetyl, fosetyl-aluminum, iprobenfos, phosphorous acid and its salts, pyrazophos, tolclofos-methyl;   organochlorine compounds: chlorothalonil, dichlofluanid, dichlorophen, flusulfamide, hexachlorobenzene, pencycuron, pentachlorphenole and its salts, phthalide, quintozene, thiophanate-methyl, tolylfluanid, N-(4-chloro-2-nitro-phenyl)-N-ethyl-4-methyl-benzenesulfonamide;   inorganic active substances: Bordeaux mixture, copper acetate, copper hydroxide, copper oxychloride, basic copper sulfate, sulfur;   others: biphenyl, bronopol, cyflufenamid, cymoxanil, diphenylamin, metrafenone, mildiomycin, oxin-copper, prohexadione-calcium, spiroxamine, tolylfluanid, N-(cyclo-propylmethoxyimino-(6-difluoro-methoxy-2,3-difluoro-phenyl)-methyl)-2-phenyl acetamide, N′-(4-(4-chloro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N-ethyl-N-methyl formamidine, N′-(4-(4-fluoro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N-ethyl-N-methyl formamidine, N′-(2-methyl-5-trifluoromethyl-4-(3-trimethyl-silanyl-propoxy)-phenyl)-N-ethyl-N-methyl formamidine, N′-(5-difluoromethyl-2-methyl-4-(3-trimethylsilanyl-propoxy)-phenyl)-N-ethyl-N-methyl formamidine, 2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazole-1-yl)-acetyl]-piperidin-4-yl}-thiazole-4-carboxylic acid methyl-(1,2,3,4-tetrahydro-naphthalen-1-yl)-amide, 2-{1-[2-(5-meth-yl-3-trifluoromethyl-pyrazole-1-yl)-acetyl]-piperidin-4-yl}-thiazole-4-carboxylic acid methyl-(R)-1,2,3,4-tetrahydro-naphthalen-1-yl-amide, acetic acid 6-tert-butyl-8-fluoro-2,3-dimethyl-quinolin-4-yl ester and methoxy-acetic acid 6-tert-butyl-8-fluoro-2,3-dimethyl-quinolin-4-yl ester.       

     The present invention furthermore relates to agrochemical compositions comprising a mixture of at least one compound I (component 1) and at least one further active substance useful for plant protection, e.g. selected from the groups A) to I) (component 2), in particular one further fungicide, e.g. one or more fungicide from the groups A) to F), as described above, and if desired one suitable solvent or solid carrier. Those mixtures are of particular interest, since many of them at the same application rate show higher efficiencies against harmful fungi. By applying compounds I together with at least one active substance from groups A) to I) a synergistic effect can be obtained, i.e. more then simple addition of the individual effects is obtained (synergistic mixtures). 
     In binary mixtures, i.e. compositions according to the invention comprising one compound I (component 1) and one further active substance (component 2), e.g. one active substance from groups A) to I), the weight ratio of component 1 and component 2 generally depends from the properties of the active substances used, usually it is in the range of from 1:100 to 100:1, regularly in the range of from 1:50 to 50:1, preferably in the range of from 1:20 to 20:1, more preferably in the range of from 1:10 to 10:1 and in particular in the range of from 1:3 to 3:1. 
     In ternary mixtures, i.e. compositions according to the invention comprising one compound I (component 1) and a first further active substance (component 2) and a second further active substance (component 3), e.g. two active substances from groups A) to I), the weight ratio of component 1 and component 2 depends from the properties of the active substances used, preferably it is in the range of from 1:50 to 50:1 and particularly in the range of from 1:10 to 10:1, and the weight ratio of component 1 and component 3 preferably is in the range of from 1:50 to 50:1 and particularly in the range of from 1:10 to 10:1. 
     Preference is also given to mixtures comprising a compound I (component 1) and at least one active substance selected from the strobilurines of group A) (component 2) and particularly selected from azoxystrobin, dimoxystrobin, fluoxastrobin, kresoximmethyl, orysastrobin, picoxystrobin, pyraclostrobin and trifloxystrobin. 
     Preference is also given to mixtures comprising a compound I (component 1) and at least one active substance selected from the carboxamides of group B) (component 2) and particularly selected from bixafen, boscalid, sedaxane, fenhexamid, metalaxyl, isopyrazam, mefenoxam, ofurace, dimethomorph, flumorph, fluopicolid (picobenzamid), zoxamide, carpropamid, mandipropamid and N-(3′,4′,5′-trifluorobiphenyl-2-yl)-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamide. 
     Preference is given to mixtures comprising a compound of formula I (component 1) and at least one active substance selected from the azoles of group C) (component 2) and particularly selected from cyproconazole, difenoconazole, epoxiconazole, fluquinconazole, flusilazole, flutriafol, metconazole, myclobutanil, penconazole, propiconazole, prothioconazole, triadimefon, triadimenol, tebuconazole, tetraconazole, triticonazole, prochloraz, cyazofamid, benomyl, carbendazim and ethaboxam. 
     Preference is also given to mixtures comprising a compound I (component 1) and at least one active substance selected from the heterocyclic compounds of group D) (component 2) and particularly selected from fluazinam, cyprodinil, fenarimol, mepanipyrim, pyrimethanil, triforine, fludioxonil, dodemorph, fenpropimorph, tridemorph, fenpropidin, iprodione, vinclozolin, famoxadone, fenamidone, probenazole, proquinazid, acibenzolar-S-methyl, captafol, folpet, fenoxanil, quinoxyfen and 5-ethyl-6-octyl-[1,2,4]triazolo[1,5-a]pyrimidine-7-ylamine. 
     Preference is also given to mixtures comprising a compound I (component 1) and at least one active substance selected from the carbamates of group E) (component 2) and particularly selected from mancozeb, metiram, propineb, thiram, iprovalicarb, benthiavalicarb and propamocarb. 
     Preference is also given to mixtures comprising a compound I (component 1) and at least one active substance selected from the fungicides given in group F) (component 2) and particularly selected from dithianon, fentin salts, such as fentin acetate, fosetyl, fosetyl-aluminium, H 3 PO 3  and salts thereof, chlorthalonil, dichlofluanid, thiophanatmethyl, copper acetate, copper hydroxide, copper oxychloride, copper sulfate, sulfur, cymoxanil, metrafenone and spiroxamine. 
     The active substances referred to as component 2, their preparation and their activity against harmful fungi is known (cf.: http://www.alanwood.net/pesticides/); these substances are commercially available. The compounds described by IUPAC nomenclature, their preparation and their fungicidal activity are also known (cf. Can. J. Plant Sci. 48(6), 587-94, 1968; EP-A 141 317; EP-A 152 031; EP-A 226 917; EP-A 243 970; EP-A 256 503; EP-A 428 941; EP-A 532 022; EP-A 1 028 125; EP-A 1 035 122; EP-A 1 201 648; EP-A 1 122 244, JP 2002316902; DE 19650197; DE 10021412; DE 102005009458; U.S. Pat. No. 3,296,272; U.S. Pat. No. 3,325,503; WO 98/46608; WO 99/14187; WO 99/24413; WO 99/27783; WO 00/29404; WO 00/46148; WO 00/65913; WO 01/54501; WO 01/56358; WO 02/22583; WO 02/40431; WO 03/10149; WO 03/11853; WO 03/14103; WO 03/16286; WO 03/53145; WO 03/61388; WO 03/66609; WO 03/74491; WO 04/49804; WO 04/83193; WO 05/120234; WO 05/123689; WO 05/123690; WO 05/63721; WO 05/87772; WO 05/87773; WO 06/15866; WO 06/87325; WO 06/87343; WO 07/82098; WO 07/90624). 
     The mixtures of active substances can be prepared as compositions comprising besides the active ingredients at least one inert ingredient by usual means, e.g. by the means given for the compositions of compounds I. Concerning usual ingredients of such compositions reference is made to the explanations given for the compositions containing compounds I. The mixtures of active substances according to the present invention are suitable as fungicides, as are the compounds of formula I. 
    
    
     I. SYNTHESIS EXAMPLES 
     With due modification of the starting compounds, the procedures shown in the synthesis examples below were used to obtain further compounds I. The resulting compounds, together with physical data, are listed in Table I below. 
     Example 1 
     N-(2-Methoxy-pyridin-4-ylmethyl)-4-(pyrimidin-5-yl)-benzenesulfonamide 
     A solution of 300 mg 4-iodo-N-(2-methoxypyridin-ylmethyl)benzenesulfonamide (WO 2006/097489) in 15 ml THF was mixed with 4-pyrimidinboronic acid and treated with 236 mg sodium carbonate in 9 ml water. After adding of 30 mg [1,4-bis-(diphenylphosphino)-butane]-palladium(II) chloride the reaction mixture was refluxed for 2 h and the solvent was removed in vacuum. The residue obtained was purified by flash chromatography on silica gel (cyclohexan/ethyl acetate, 1:1) to yield the title compound as yellow oil (356 mg).  1 H-NMR (CDCl 3 ): δ=3.85 (s, 3H), 4.2 (m, 2H), 5.0 (m, 1H), 6.5 (s, 1H), 6.8 (m, 1H), 7.7 (d, 2H), 8.0 8d, 2H), 8.05 (m, 1H), 9.0 (s, 2H) and 9.3 ppm (s, 1H) 
     Example 2 
     N-(2-Methoxy-pyridin-4-ylmethyl)-4-(6-methyl-pyridin-2-yl)-benzenesulfonamide 
     A solution of 300 mg 4-iodo-N-(2-methoxypyridin-ylmethyl)benzenesulfonamide (WO 2006/097489) in 5 ml DMF was mixed with 2-methyl-6-tributylstannanyl-pyridine (624 mg) and treated with 36 mg copper(I) iodide. After adding of 30 mg [1,4-bis-(diphenylphosphino)-butane]-palladium(II) chloride the reaction mixture was stirred at 90° C. for 2 h and for 20 h at 23° C. The solvent was removed in vacuum and the residue obtained was purified by flash chromatography on silica gel (cyclohexan/ethyl acetate, 1:1) to yield the title compound as yellow oil (369 mg).  1 H-NMR (CDCl 3 ): δ=2.6 (s, 3H), 3.85 (s, 3H), 4.1 (m, 3H), 5.2 (m, 1H), 6.6 (s, 1H), 6.7 (m, 1H), 7.2 (m, 1H), 7.5 (m, 1H), 7.7 (m, 1H), 7.9 (m, 2H) 8.05 (m, 1H) and 8.1 ppm (m, 2H). 
     
       
         
           
               
             
               
                 TABLE I 
               
             
            
               
                   
               
               
                 Compounds of formula I 
               
            
           
           
               
               
               
               
               
               
            
               
                 no. 
                 (R a ) n   
                 R 
                 A 
                 Het 
                 Physical data* 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1 
                 — 
                 H 
                 A-1 
                 thien-2-yl 
                 168-171° C. 
               
               
                 2 
                 — 
                 H 
                 A-4 
                 phenylbenzofuran-2-yl 
                 oil 
               
               
                 3 
                 — 
                 H 
                 A-5 
                 phenylbenzofuran-2-yl 
                 oil 
               
               
                 4 
                 — 
                 H 
                 A-2 
                 phenylbenzofuran-2-yl 
                 oil 
               
               
                 5 
                 — 
                 H 
                 A-1 
                 thien-3-yl 
                 210° C. 
               
               
                 6 
                 — 
                 H 
                 A-1 
                 3-chloro-pyridin-4-yl 
                 oil 
               
               
                 7 
                 %-(CH) 4 -# 
                 H 
                 A-1 
                 6-methoxy-pyridin-3-yl 
                 177-181° C. 
               
               
                 8 
                 %-(CH) 4 -# 
                 H 
                 A-1 
                 furan-3-yl 
                 oil 
               
               
                 9 
                 — 
                 H 
                 A-1 
                 1-carboxyl acid tert.butyl ester-pyrrol-2yl 
                 oil 
               
               
                 10 
                 %-(CH) 4 -# 
                 H 
                 A-1 
                 oxazol-5-yl 
                 190-191° C. 
               
               
                 11 
                 2-OCH 3   
                 H 
                 A-1 
                 3-chloro-pyridin-4-yl 
                 oil 
               
               
                 12 
                 — 
                 H 
                 A-6 
                 3-chloro-pyridin-4-yl 
                 oil 
               
               
                 13 
                 — 
                 H 
                 A-2 
                 3-chloro-pyridin-4-yl 
                 oil 
               
               
                 14 
                 3-OCH 3   
                 H 
                 A-1 
                 3-chloro-pyridin-4-yl 
                 oil 
               
               
                 15 
                 — 
                 H 
                 A-1 
                 pyridin-2-yl 
                 115-117° C. 
               
               
                 16 
                 — 
                 H 
                 A-1 
                 pyridin-4-yl 
                 203-210° C. 
               
               
                 17 
                 — 
                 H 
                 A-1 
                 2-chloro-pyridin-3-yl 
                 oil 
               
               
                 18 
                 — 
                 H 
                 A-1 
                 6-fluoro-pyridin-3-yl 
                 oil 
               
               
                 19 
                 — 
                 H 
                 A-1 
                 6-chloro-pyridin-3-yl 
                 197° C. 
               
               
                 20 
                 — 
                 H 
                 A-1 
                 3-methyl-thiophen-2-yl 
                 180° C. 
               
               
                 21 
                 — 
                 H 
                 A-1 
                 4-methyl-thiophen-3-yl 
                 167° C. 
               
               
                 22 
                 — 
                 H 
                 A-1 
                 6-methoxy-pyridin-3-yl 
                 160-169° C. 
               
               
                 23 
                 — 
                 H 
                 A-1 
                 5-chloro-thiophen-2-yl 
                 160-169° C. 
               
               
                 24 
                 — 
                 H 
                 A-1 
                 5-methyl-thiophen-2-yl 
                 177-180° C. 
               
               
                 25 
                 — 
                 H 
                 A-1 
                 pyrimidin-2-yl 
                 140-145° C. 
               
               
                 26 
                 — 
                 H 
                 A-1 
                 furan-3-yl 
                 162-178° C. 
               
               
                 27 
                 — 
                 H 
                 A-1 
                 5-acetyl-thiophen-2-yl 
                 199-202° C. 
               
               
                 28 
                 — 
                 H 
                 A-1 
                 5-ethanon O-methyloxim-thiophen-2-yl 
                 181-186° C. 
               
               
                 29 
                 — 
                 H 
                 A-1 
                 5-ethanon O-ethyloxim-thiophen-2-yl 
                 165-170° C. 
               
               
                 30 
                 — 
                 H 
                 A-1 
                 5-ethanon O-hexyloxim-thiophen-2-yl 
                 107-118° C. 
               
               
                 31 
                 %-(CH) 4 -# 
                 H 
                 A-2 
                 6-ethoxy-pyridin-3-yl 
                 oil 
               
               
                 32 
                 %-(CH) 4 -# 
                 H 
                 A-1 
                 6-ethoxy-pyridin-3-yl 
                 oil 
               
               
                 33 
                 %-(CH) 4 -# 
                 H 
                 A-1 
                 5-trifluoromethyl-isoxazol-3-yl 
                 153-154° C. 
               
               
                 34 
                 %-(CH) 4 -# 
                 H 
                 A-1 
                 2-methylthiazol-4-yl 
                 158° C. 
               
               
                 35 
                 %-(CH) 4 -# 
                 H 
                 A-1 
                 4-chloro-5-trifluoromethyl-isothiazol-3-yl 
                 oil 
               
               
                 36 
                 2-OCH 3   
                 H 
                 A-1 
                 5-trifluoromethylpyridin-2-yl 
                 2.88 min, 
               
               
                   
                   
                   
                   
                   
                 424.00 
               
               
                 37 
                 2,3-(CH 3 ) 2   
                 H 
                   
                 5-trifluoromethylpyridin-2-yl 
                 2.51, 422.10 
               
               
                 38 
                 2-OCH 3   
                 H 
                 A-1 
                 3-chloro-5-trifluoromethyl-pyridin-2-yl 
                 2.94 min, 
               
               
                   
                   
                   
                   
                   
                 455.60 
               
               
                 39 
                 2,3-(CH 3 ) 2   
                 H 
                 A-1 
                 3-chloro-5-trifluoromethyl-pyridin-2-yl 
                 2.67 min, 
               
               
                   
                   
                   
                   
                   
                 455.60 
               
               
                 40 
                 %-(CH 2 ) 3 -# 
                 H 
                 A-1 
                 5-trifluoromethylpyridin-2-yl 
                 2.91 min, 
               
               
                   
                   
                   
                   
                   
                 434.10 
               
               
                 41 
                 2-OCH 3   
                 H 
                 A-1 
                 pyrimidin-2-yl 
                 149-152° C. 
               
               
                 42 
                 2,3-(CH 3 ) 2   
                 H 
                 A-1 
                 pyrimidin-2-yl 
                 202-206° C. 
               
               
                 43 
                 2-OCH 3   
                 H 
                 A-1 
                 oxazol-5-yl 
                 145-147° C. 
               
               
                 44 
                 2,3-(CH 3 ) 2   
                 H 
                 A-1 
                 oxazol-5-yl 
                 201-206° C. 
               
               
                 45 
                 2-OCH 3   
                   
                 A-1 
                 3-methyl-thiazol-5-yl 
                 2.47 min, 
               
               
                   
                   
                   
                   
                   
                 375.80 
               
               
                 46 
                 2,3-(CH 3 ) 2   
                 H 
                 A-1 
                 3-methyl-thiazol-5-yl 
                 2.19 min, 
               
               
                   
                   
                   
                   
                   
                 373.80 
               
               
                 47 
                 2-OCH 3   
                 H 
                 A-1 
                 furan-3-yl 
                 oil 
               
               
                 48 
                 2-OCH 3   
                 H 
                 A-1 
                 thien-3-yl 
                 121-124° C. 
               
               
                 49 
                 2-OCH 3   
                 H 
                 A-1 
                 6-methoxy-pyridin-3-yl 
                 129-133° C. 
               
               
                 50 
                 2-OCH 3   
                 H 
                 A-1 
                 pyrimidin-4-yl 
                 145-147° C. 
               
               
                 51 
                 2-OCH 3   
                 H 
                 A-1 
                 6-chloro-pyridin-3-yl 
                 183-186° C. 
               
               
                 52 
                 2-OCH 3   
                 H 
                 A-1 
                 pyridin-3-yl 
                 117-118° C. 
               
               
                 53 
                 2-OCH 3   
                 H 
                 A-1 
                 pyridin-4-yl 
                 155-157° C. 
               
               
                 54 
                 2-OCH 3   
                 H 
                 A-1 
                 6-methyl-pyridin-3-yl 
                 154-157° C. 
               
               
                 55 
                 2-OCH 3   
                 H 
                 A-1 
                 oxazol-4-yl 
                 145-147 
               
               
                 56 
                 2-OCH 3   
                 H 
                 A-1 
                 6-methyl-pyridin-2-yl 
                 oil 
               
               
                 57 
                 2-OCH 3   
                 H 
                 A-1 
                 1-phenyl-1H-pyrazol-4-yl 
                 158-160° C. 
               
               
                 58 
                 3-OCH 3   
                 H 
                 A-1 
                 thien-3-yl 
                 175-176° C. 
               
               
                 59 
                 3-OCH 3   
                 H 
                 A-1 
                 furan-3-yl 
                 142-144° C. 
               
               
                 60 
                 3-OCH 3   
                 H 
                 A-1 
                 6-chloro-pyridin-3-yl 
                 158-161° C. 
               
               
                 61 
                 3-OCH 3   
                 H 
                 A-1 
                 6-methoxy-pyridin-3-yl 
                 172-174° C. 
               
               
                 62 
                 3-OCH 3   
                 H 
                 A-1 
                 pyrimidin-4-yl 
                 145-149° C. 
               
               
                 63 
                 3-OCH 3   
                 H 
                 A-1 
                 pyridin-3-yl 
                 170-173° C. 
               
               
                 64 
                 3-OCH 3   
                 H 
                 A-1 
                 pyridin-4-yl 
                 1.37 min, 
               
               
                   
                   
                   
                   
                   
                 355.80 
               
               
                 65 
                 2-OCH 3   
                 H 
                 A-2 
                 1-methyl-1H-pyrazol-3-yl 
                 101-104° C. 
               
               
                 66 
                 2,3-(CH 3 ) 2   
                 H 
                 A-1 
                 1-methyl-1H-pyrazol-3-yl 
                 147-150° C. 
               
               
                 67 
                 2,3-(CH 3 ) 2   
                 H 
                 A-1 
                 furan-2-yl 
                 191-195° C. 
               
               
                 68 
                 2,3-(CH 3 ) 2   
                 H 
                 A-1 
                 thien-2-yl 
                 171-174° C. 
               
               
                 69 
                 2,3-(CH 3 ) 2   
                 H 
                 A-1 
                 thien-3-yl 
                 185-192° C. 
               
               
                 70 
                 2,3-(CH 3 ) 2   
                 H 
                 A-1 
                 furan-3-yl 
                 170-173° C. 
               
               
                 71 
                 2,3-(CH 3 ) 2   
                 H 
                 A-1 
                 6-chloro-pyridin-3-yl 
                 173-180° C. 
               
               
                 72 
                 2,3-(CH 3 ) 2   
                 H 
                 A-1 
                 6-methoxy-pyridin-3-yl 
                 175-183° C. 
               
               
                 73 
                 2,3-(CH 3 ) 2   
                 H 
                 A-1 
                 pyrimidin-4-yl 
                 121-126° C. 
               
               
                 74 
                 2,3-(CH 3 ) 2   
                 H 
                 A-1 
                 pyridin-3-yl 
                 140-148° C. 
               
               
                 75 
                 2,3-(CH 3 ) 2   
                 H 
                 A-1 
                 pyrimidin-4-yl 
                 182-190° C. 
               
               
                 76 
                 2,3-(CH 3 ) 2   
                 H 
                 A-1 
                 3-chloro-5-trifluoromethyl-pyridin-2-yl 
                 oil; 2.7 min, 
               
               
                   
                   
                   
                   
                   
                 456.05 
               
               
                   
               
               
                 *Physical data: m.p. [° C.]; HPLC/MS R t  [min], M + H + . HPLC column: RP-18 column (Chromolith Speed ROD from Merck KgaA, Germany), 50 mm × 4.6 mm; Eluent: acetonitrile + 0.1% trifluoroacetic acid (TFA)/water + 0.1% TFA (gradient from 5:95 to 95:5 in 5 min at 40° C., flow of 1.8 ml/min). MS: Quadrupol Elektrospray Ionisation, 80 V (positive mode). 
               
               
                 For A, the definition is selected from A-1 to A-141 as defined earlier herein. 
               
               
                 For (R a ) n , “—” indicates that n is 0. For (R a ) n , being a divalent radical, % indicates the point of attachment at 2-position and # at 3-position of the pyridine ring. 
               
            
           
         
       
     
     II. EXAMPLES OF THE ACTION AGAINST HARMFUL FUNGI 
     The fungicidal action of the compounds of the formula I was demonstrated by the following experiments using synthsis examples as defined in Table I: 
     A) Microtiter tests 
     B) 
     The active substances were formulated separately as a stock solution in dimethyl sulfoxide (DMSO) at a concentration of 10 000 ppm. 
     After pipetting the stock solution into a microtiter plate (MTP) and diluting it to the stated active substance concentration using a nutrient medium for fungi and adding a spore suspension of the respective fungal pathogen, the plates were placed in a water vapor-saturated chamber at temperatures of 18° C. Using an absorption photometer, the MTPs were measured at 405 nm on day 7 after the inoculation. The measured parameters were compared to the growth of the active substance-free control variant (=100%) and the fungus- and active substance-free blank value to determine the relative growth in % of the pathogens in the individual active substances. 
     Use Example 1 
     Activity against the late blight pathogen  Phytophthora infestans  The stock solutions were mixed according to the ratio, pipetted into a MTP and diluted with water to the stated concentrations. A spore suspension of  Phytophtora  infestans containing a pea juice-based aqueous nutrient medium was then added. 
     In this test, the samples which had been treated with 125 ppm of the active compound from examples 2, 4, 11, 12, 13, 17, 31 and 32, respectively, showed up to at most 15% relative growth of the pathogen. 
     Use Example 2 
     Activity against leaf blotch on wheat caused by  Septoria tritici  The stock solutions were mixed according to the ratio, pipetted into a MTP and diluted with water to the stated concentrations. A spore suspension of  Septoria tritici  in an aqueous yeast-bactopeptone-glycerol solution was then added. 
     In this test, the samples which had been treated with 125 ppm of the active compound from examples 11, 13 and 14, respectively, showed up to at most 15% relative growth of the pathogen. 
     Use Example 3 
     Activity Against Rice Blast  Pyricularia oryzae    
     The stock solutions were mixed according to the ratio, pipetted into a MTP and diluted with water to the stated concentrations. A spore suspension of  Pyricularia oryzae  in an aqueous yeast-bactopeptone-glycerol solution was then added. 
     In this test, the samples which had been treated with 125 ppm of the active compound from examples 4, 17, 20, 21, 24, 29 and 31, respectively, showed up to at most 15% relative growth of the pathogen. 
     B) Greenhouse 
     The spray solutions were prepared in several steps: 
     The stock solution were prepared: a mixture of acetone and/or dimethylsulfoxide and the wetting agent/emulsifier Wettol, which is based on ethoxylated alkylphenoles, in a relation (volume) solvent-emulsifier of 99 to 1 was added to 25 mg of the compound to give a total of 10 ml. Water was then added to total volume of 100 ml. 
     This stock solution was diluted with the described solvent-emulsifier-water mixture to the given concentration. 
     Use Example 4 
     Preventative Control of Brown Rust on Wheat Caused by  Puccinia recondita    
     The first two developed leaves of pot-grown wheat seedling were sprayed to run-off with an aqueous suspension, containing the concentration of active ingredient as described. The next day the plants were inoculated with spores of  Puccinia recondita . To ensure the success the artificial inoculation, the plants were transferred to a humid chamber without light and a relative humidity of 95 to 99% and 20 to 22° C. for 24 h. Then the trial plants were cultivated for 6 days in a greenhouse chamber at 22-26° C. and a relative humidity between 65 and 70%. The extent of fungal attack on the leaves was visually assessed as % diseased leaf area. 
     In this test, the plants which had been treated with 250 ppm of the active compound from examples 36, 37, 38, 39, 49 and 67, respectively, showed an infection of less than or equal to 15% whereas the untreated plants were 90% infected. 
     Use Example 5 
     Control of Late Blight on Tomatoes Caused by  Phytophthora infestans    
     Young seedlings of tomato plants were grown in pots. These plants were sprayed to run-off with an aqueous suspension, containing the concentration of active ingredient as described. The next day, the treated plants were inoculated with an aqueous suspension of sporangia of  Phytophthora infestans . After inoculation, the trial plants were immediately transferred to a humid chamber. After 6 days at 18 to 20° C. and a relative humidity close to 100% the extent of fungal attack on the leaves was visually assessed as % diseased leaf area. 
     In this test, the plants which had been treated with 250 ppm of the active compound from examples 5, 7, 10, 15, 18, 33, 36, 37, 40, 41, 42, 43, 45, 47, 49, 50, 51, 52, 53, 54, 56, 57, 58, 59, 60, 61, 62, 63, 64, 67, 70, 71, 72 and 74, respectively, showed an infection of less than or equal to 15% whereas the untreated plants were 90% infected. 
     Use Example 6 
     Protective Control of Rust on Soybeans Caused by  Phakopsora pachyrhizi    
     Leaves of pot-grown soybean seedlings were sprayed to run-off with an aqueous suspension, containing the concentration of active ingredient as described. The plants were allowed to air-dry. The next day the plants were inoculated with spores of  Phakopsora pachyrhizi . To ensure the success the artificial inoculation, the plants were transferred to a humid chamber with a relative humidity of about 95% and 23 to 27° C. for 24 h. The trial plants were cultivated for 14 days in a glasshouse chamber at 23-27° C. and a relative humidity between 60 and 80%. The extent of fungal attack on the leaves was visually assessed as % diseased leaf area. 
     In this test, the plants which had been treated with 250 ppm of the active compound from examples 45, 50, 52, 53, 62, 72, 73 and 74, respectively, showed an infection of less than or equal to 15% whereas the untreated plants were 90% infected. 
     Use Example 7 
     Curative Control of Rust on Soy Beans Caused by  Phakopsora pachyrhizi    
     Leaves of pot-grown soybean seedlings were inoculated with spores of  Phakopsora pachyrhizi . To ensure the success of the artificial inoculation, the plants were transferred to a humid chamber with a relative humidity of about 95% and 23 to 27° C. for 24 h. The next day the plants were sprayed to run-off with an aqueous suspension, containing the concentration of active ingredient as described. The plants were allowed to air-dry. Then the trial plants were cultivated for 14 days in a greenhouse chamber at 23-27° C. and a relative humidity between 60 and 80%. The extent of fungal attack on the leaves was visually assessed as % diseased leaf area. 
     In this test, the plants which had been treated with 250 ppm of the active compound from examples 1, 15, 23, 28, 41, 42, 43 and 44, respectively, showed an infection of less than or equal to 15% whereas the untreated plants were 90% infected.