Patent Publication Number: US-2013252950-A1

Title: Targeting mtor substrates in treating proliferative diseases

Description:
RELATED APPLICATIONS 
     This application claims priority under 35 U.S.C. §119(e) to U.S. provisional patent application, U.S. Ser. No. 61/403,932, filed Sep. 23, 2010, which is incorporated herein by reference. 
    
    
     GOVERNMENT SUPPORT 
     This invention was made with U.S. Government support under grant numbers GM051405 and HG3456 awarded by the National Institutes of Health. The U.S. Government has certain rights in the invention. 
    
    
     BACKGROUND 
     mTOR is an evolutionarily conserved ser/thr protein kinase that controls many critical cellular processes including growth, protein translation, metabolic flux, and cell survival. mTOR functions as the core catalytic component of two structurally and functionally distinct signaling complexes. mTOR complex 1 (mTORC1) regulates cell growth and is responsible for the well-characterized role of mTOR in controlling protein translation whereas mTOR complex 2 (mTORC2) regulates cell survival and the actin cytoskeleton (1-3). The mechanisms responsible for modulating mTORC1 and mTORC2 activity in response to upstream inputs such as growth factors, energetic status, and amino acid levels have been well studied (1). In contrast, relatively few direct substrates of mTOR have been identified and in many cases the mechanisms underlying mTOR&#39;s ability to regulate important aspects of cell biology are not known. 
     Misregulated mTOR activity is a common feature of most cancers (2). Despite great interest, clinical trials for evaluating the selective mTORC1 inhibitor rapamycin as an anti-cancer agent have met with limited success (3). Rapamycin resistance has emerged as a major challenge to its clinical use (4) and is caused in part by feedback loops that activate the PI3K and MAPK signaling pathways in rapamycin-treated cells through poorly understood mechanisms (5, 6). 
     SUMMARY OF THE INVENTION 
     Functional characterization of the mTOR signaling pathways has been hampered by the paucity of substrates that have been identified to date. Identifying novel substrates of mTORC1 and mTORC2 is important for making progress toward our general understanding how mTOR signals to downstream effectors and to specifically define components of the feedback loops involved in rapamycin resistance. The best-characterized mTORC1 substrates include p70S6K and 4EBP, whereas mTORC2 phosphorylates several members of the AGC kinase family, including Akt, SGK, and PKC. 
     The present invention is based in part on large-scale quantitative phospho-proteomics experiments that were performed to define the entire signaling networks downstream of both mTORC1 and mTORC2. Novel mTORC1 substrates identified herein include, but are not limited to Grb10, FOXK1, ZEB2, NDRG3, LARP1, SRPK2, CDK12, MIB1, and IBTK. 
     Extensive characterization of a novel mTORC1 substrate, the growth factor receptor-bound protein 10 (Grb10), shows that mTORC1-mediated phosphorylation stabilizes Grb10, leading to feedback inhibition of the PI3K and MAPK pathways. In addition, Grb10 expression was shown to be frequently downregulated in a variety of cancers. Interestingly, loss of Grb10 and the well-established tumor suppressor PTEN are mutually exclusive events. Grb10 has been found to be both a novel mTORC1 substrate and a tumor suppressor with relevance across a broad spectrum of cancer subtypes. 
     In some aspects, the invention provides methods for determining mTOR kinase activity in a cell, the method comprising obtaining a cancer cell from a subject diagnosed to have a cancer, determining the level of Grb10 phosphorylation in the cell, and comparing the level of Grb10 phosphorylation to a reference level, wherein if the level of Grb10 phosphorylation in the cell is higher than the reference level, then the cell is determined to exhibit an elevated level of mTOR kinase activity. In some embodiments, the cell is a normal or healthy cell. In some embodiments, the cell is a cell obtained from a subject not diagnosed with a neoplastic disease. In some embodiments, the cell is a cell obtained from a subject not diagnosed with a cancer. In some embodiments, the cell is a neoplastic cell. In some embodiments, the cell is a cancer cell. In some embodiments, the cell is a cell obtained from a subject diagnosed with a neoplastic disease, for example, with a cancer. 
     In some aspects, the invention provides methods for selecting a treatment of a neoplastic disease, for example, of a cancer, in a subject, the method comprising obtaining a cell from a subject diagnosed to have a neoplastic disease, for example, a cancer, exhibiting an elevated level of mTOR activity; determining the level of Grb10 expression in the cell; and comparing the level of Grb10 expression to a reference level, wherein if the level of Grb10 expression in the cell is higher than the reference level, then the cell is determined to exhibit a high likelihood of expressing an elevated level of PI3K, Akt, and/or MAPK activity upon being contacted with an mTORC1 inhibitor. 
     Other aspects of this invention provide methods for determining mTOR kinase activity in a cell by determining the level of phosphorylation of a phosphorylation site disclosed in Table 1, 2, 3, 7, 8, or 11 in the cell, and comparing the level of phosphorylation to a reference level, wherein if the level of phosphorylation is higher than the reference level, then the cell is determined to exhibit an elevated level of mTOR kinase activity, or if the level of phosphorylation is equal or lower than the reference level, then the cell is determined to not exhibit an elevated level of mTOR kinase activity. In certain embodiments, if a phosphorylation site determined to exhibit a higher level of phosphorylation in the cell as compared to the reference level is a class I phosphorylation site, then the cell is determined to exhibit an elevated level of rapamycin-sensitive mTORC1 activity. In certain embodiments, if a phosphorylation site determined to exhibit a higher level of phosphorylation in the cell as compared to the reference level is a class II phosphorylation site, then the cell is determined to exhibit an elevated level of rapamycin-insensitive mTORC1 and/or mTORC2 activity. In some embodiments, if a phosphorylation site determined to exhibit a higher level of phosphorylation in the cell as compared to the reference level is a class III phosphorylation site, then the cell is determined to exhibit an elevated level of rapamycin-sensitive mTOR activity, or an elevated level of rapamycin-insensitive mTOR activity, or both. 
     In some embodiments, the methods provided herein further comprise selecting a method of treatment of the subject based on the level of phosphorylation of the phosphorylation site. In some embodiments, if the cell is determined to exhibit an elevated level of mTOR kinase activity, then a method of treatment is selected that includes administering an effective amount of an mTOR kinase inhibitor to the subject. In some embodiments, if the cell is determined to not exhibit an elevated level of mTOR kinase activity, then a method of treatment is selected that does not include administering an mTOR kinase inhibitor. In some embodiments, if the cell is determined to exhibit an elevated level of rapamycin-sensitive mTORC1 activity, then a method of treatment is selected that comprises administering an effective amount of an inhibitor of rapamycin-sensitive mTORC1 kinase activity (e.g., rapamycin or a rapamycin analog) to the subject. In some embodiments, if the cell is determined to exhibit an elevated level of rapamycin-insensitive mTORC1 and/or mTORC2 activity, then a method of treatment is selected that comprises administering an effective amount of an inhibitor of rapamycin-insensitive mTORC1 kinase activity to the subject. In some embodiments, if the cell is determined to exhibit an elevated level of rapamycin-sensitive mTOR kinase activity, or an elevated level of rapamycin-insensitive mTOR kinase activity, or both, then a method of treatment is selected that comprises administering an effective amount of an inhibitor of rapamycin-sensitive and rapamycin-insensitive mTOR kinase activity or a combination of an inhibitor of rapamycin-sensitive mTOR kinase activity and an inhibitor of rapamycin-insensitive mTOR kinase activity to the subject. 
     In some embodiments, the method of treatment further comprises administering to the subject an effective amount of a compound that stabilizes Grb10 or that inhibits the degradation of Grb10. In some embodiments, the method of treatment further comprises administering an effective amount of an inhibitor of PI3K, Akt, or MAPK to the subject. 
     Some aspects of this invention provide a phosphoproteomics array that includes a plurality of phosphosensitive antibodies or antibody fragments each of which specifically binds to phosphorylation site disclosed in Table 1, 2, 3, 7, 8, or 11. In some aspects, the invention also provides a method of using a phosphoproteomics array to determine mTOR activity in a cell by contacting a proteinaceous sample derived from a cell, for example, from a cancer cell, with a phosphoproteomics array as described herein under conditions suitable for a protein expressed in the cell to bind to an antibody or antibody fragment of the array, determining the level of phosphorylated protein bound to an antibody or antibody fragment of the array, and comparing the level of phosphorylated protein bound to an antibody or antibody fragment of the array to a reference level. If the level phosphorylated protein in the sample derived from the cell is higher than the reference level, then the cell is determined to exhibit an elevated level of mTOR kinase activity. 
     In other aspects, the invention provides methods of identifying an mTOR kinase inhibitor by contacting an mTOR kinase with a polypeptide with a phosphorylation site disclosed in Table 1, 2, 3, 7, 8, or 11 under conditions suitable for the mTOR kinase to phosphorylate the phosphorylation site in the presence of a candidate agent, determining the level of phosphorylation at the phosphorylation site, and comparing the level of phosphorylation to a reference level. If the level of phosphorylation is lower than the reference level, then the candidate agent is identified as an mTOR kinase inhibitor. 
     In some embodiments involving a phosphorylation site disclosed in Table 1, 2, 3, 7, 8, or 11, the phosphorylation site is not a phosphorylation site previously known to be an mTOR target. 
     The subject matter of this application may involve, in some cases, interrelated products, alternative solutions to a particular problem, and/or a plurality of different uses of a single method or agent. Other advantages, features, and uses of the invention will become apparent from the following detailed description of non-limiting embodiments of the invention when considered in conjunction with the accompanying drawings. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1 . Sample preparation and data analysis for quantitative phosphorylation profiling of mTOR signaling. (A) Schematics of the two quantitative mass spectrometry experiments are shown with a plot highlighting the distribution of phosphopeptides identified in each screen. See data summary in Table 5. Note that most of the phosphopeptides have a ratio of 1:1 between the light and heavy populations and hence have a value close to 0 on a Log 2  axis. Proteins with downregulated phosphorylation in each screen are highlighted in the red box. (B) Typical quantitative MS and MS/MS spectra in which LS*SLRAS*TSKSESSQK (SEQ ID NO: 1) from ribosomal protein S6 (S235 and S240) are identified as a rapamycin-sensitive phosphopeptide. Note the light and heavy peptides differ by 26 Da, corresponding to 2 labeled Lys and 1 labeled Arg in this particular peptide. Sequence in lower panel: SEQ ID NO: 1722. (C) Quantitative differences between the rapamycin-sensitive and -insensitive mTOR downstream phosphorylation events. Phosphopeptides identified in both screens were extracted and their corresponding Log 2  ratios (fold-changes) were plotted. (D) The top ten pathways enriched in the down-regulated phospho-proteins identified in the rapamycin (Rapa) screen. 
         FIG. 2 . Phosphorylation of Grb10 at S501/S503 is sensitive to rapamycin inhibition. (A) Identification of a doubly-phosphorylated rapamycin-sensitive Grb10 peptide (MNILSS*QS*PLHPSTLNAVIHR, SEQ ID NO: 2, * indicates phosphorylation sites) corresponding to S501/S503. (B) Evolutionary conservation of Grb10 S501/S503 among vertebrate species. (C) Phosphorylation of Grb10 at S501/S503 shows rapamycin sensitivity in vivo. TSC2−/− cells were starved for serum and treated with 20 nM rapamycin for the indicated times. Sequences, from top to bottom: SEQ ID NO: 1723 to SEQ ID NO: 1727, respectively. (D) Phosphorylation of Grb10 at S501/501 is sensitive to amino acids withdrawal. TSC2−/− cells were starved in DMEM overnight and then transferred to D-PBS for the indicated times. (E) Phosphorylation of Grb10 at S501/S503 is not affected by the pan-kinase inhibitor, staurosporine. TSC2−/− cells were starved for serum and treated with either 100 nM staurosporine or Ku-0063794 at the indicated concentrations for two hours. (F) Grb10 phosphorylation is increased upon growth factor stimulation. Wild type (WT) mouse embryonic fibroblasts (MEFs) were starved for serum overnight and then were stimulated with insulin (100 nM) or serum (10%) for 15 min. The cells were preincubated with the indicated compounds for two hours. AktVIII (1 μM) is a specific inhibitor of Akt whereas AZD (AZD6244, 5 μM) specifically inhibits MEK. Rapamycin (rapa) was used at 20 nM. (G) Grb10 phosphorylation at S501/S503 is sensitive to various mTOR kinase inhibitors. TSC2−/− cells were serum-starved and treated with the indicated compounds for two hours. The concentrations of the compounds were rapamycin 20 nM, LY (LY294002) 20 μM, BEZ235 (NVP-BEZ235) 500 nM, torin 100 nM, and pp 242 1 μM. 
         FIG. 3 . mTOR-mediated Grb10 phosphorylation is important for Grb10 stability. (A) Grb10 interacts with raptor, but not rictor. HA-tagged Grb10 was co-transfected with Myc-raptor or Myc-rictor in HEK293T cells. Cells were lysed in lysis buffer A, and the lysates were subjected to immunoprecipitation using anti-HA antibody conjugated beads. Raptor and rictor were probed with an antibody against the Myc-tag. (B) Grb10 is phosphorylated by mTOR in vitro. Recombinant Grb10 was prepared from bacteria (the GST-fused Grb10 shows a molecular weight of 80 kDa) and was incubated with recombinant mTOR in vitro. Phosphorylation of Grb10 at S501/S503 was detected by using the phospho-specific antibody against these two sites. (C) Long-term rapamycin treatment leads to Grb10 degradation in TSC2−/− cells. Note that Grb10 protein expression levels inversely correlated with Akt activity. Grb10 is highly overexpressed in TSC2−/− cells. mRNA level was determined using quantitative RT-PCR based on three biological replicate experiments. (D) Knockdown of raptor in TSC2−/− cells decreased Grb10 protein level. Cells were starved overnight and the lysates were probed with the antibodies indicated. (E) Grb10 is highly overexpressed in TSC2−/− cells. (F) S501A/S503A mutant is unstable compared with the wild-type or the S501D/S503D mutant. The same amount of DNA was transfected into HEK293T cells. (G) Rapamycin failed to induce degradation of the S501D/S503D mutant. S501D/S503D mutant (DD) was stably expressed in TSC2−/− cells and cells were treated with 20 nM rapamycin for the indicated times. Endogenous Grb10 was detected using an antibody that preferentially recognizes mouse Grb10 whereas the Grb10 DD mutant (of human origin) was detected using an anti-HA antibody. 
         FIG. 4 . Grb10 is involved in the feedback inhibition loop from mTORC1 to PI3K and MAPK and GRB10 mRNA expression is significantly down-regulated in many cancers and is negatively correlated with PTEN expression. (A) Knockdown of Grb10 in TSC2−/− cells resulted in PI3K and MAPK hyperactivation after insulin or IGF stimulation. (B) Knockdown of Grb10 in TSC2−/− cells protected cells against apoptosis. Grb10 knockdown and control cells were starved overnight and then treated with 100 nM staurosporine for 5 hrs to induce apoptosis. (C) Box plots indicating that GRB10 expression is significantly lower in many tumor types compared to their corresponding normal tissues. (Only the tumor types that showed significantly lower GRB10 expression in cancer vs. normal in at least three independent microarray datasets are included). (D) Heat maps indicating a strong negative correlation between GRB10 and PTEN expression in breast carcinomas and myelomas. Low levels of GRB10 expression rarely occurred in tumors that also showed low levels of PTEN expression. (E) Scatter plots comparing the expression levels of GRB10 and PTEN levels in the normal and tumor samples, collected overall from 6 different tissue types, where GRB10 was shown to be significantly down-regulated in cancer vs. normal. The negative correlation between GRB10 and PTEN expression is evident in the tumor (P&lt;0.001) but not in the corresponding normal samples. 
         FIG. 5 . Data analysis for the rapamycin screen and Ku-0063794 screen. (A) Phosphopeptides enrichment in the second biological replicate experiment of the rapamycin screen. Number of phospho- and nonphospho-peptides, in each SCX fraction was plotted. (B) Number of downregulated proteins in the two biological replicates of the rapamycin screen. (C) Ku-0063794 inhibits insulin-induced Akt phosphorylation. (D) Pathways enriched in the downregulated phospho-proteins identified in the Ku-0063794 screen. The top ten overrepresented pathways were shown. Analysis was performed using DAVID. See Huang D W, Sherman B T, Lempicki R A.  Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources . Nature Protoc. 2009; 4(1):44-57; and Dennis G Jr, Sherman B T, Hosack D A, Yang J, Gao W, Lane H C, Lempicki R A.  DAVID: Database for Annotation, Visualization, and Integrated Discovery . Genome Biol. 2003; 4(5):P3; both incorporated herein by reference for disclosure of integrative analysis methods for large datasets. 
         FIG. 6 . Examples of protein phosphorylation changes identified in the rapamycin and Ku-0063794 screens. Note that the light cells were treated with rapamycin and the heavy cells were treated with DMSO in the rapamycin screen (2 nd  biological replicate). For the Ku-0063794 screen, light cells were treated with rapamycin whereas the heavy cells were treated with a combination of rapamycin and Ku-0063794. (A) Phosphorylation changes of different sites on 4EBP in the rapamycin screen and Ku-0063794 screen. Phosphorylation of T36/T45 was partially responsive to rapamycin and was completely abolished as a result of Ku-0063794 treatment. In contrast, T70 phosphorylation is mTOR-independent (B) NRDG1 phosphorylation at S330/S333 was sensitive to Ku-0063794 but not rapamycin inhibition. (C) GSK3β phosphorylation at S9 decreased in both rapamycin and Ku-0063794 screen. 
         FIG. 7 . Identification of the rapamycin-sensitive phosphorylation sites on mTOR (A) Intensities of an mTOR peptide  2471 AGTTVPES*HIS*FIGDGLVKPEALNKK 2496  (SEQ ID NO: 3, * indicates phosphorylation sites) from the rapamycin-treated (Light) and control (Heavy) TSC2−/− cells (B) Domain structure of mTOR and conservation of S2478 and S2481 across different species. Sequences, from top to bottom: SEQ ID NO: 1728 to SEQ ID NO: 1735, respectively. (C) Immunoblot experiments showing phospho-mTOR at S2481 is inhibited by acute rapamycin treatment. TSC2−/− cells were starved and then treated with 20 nM rapamycin for the indicated times. (D) mTOR kinase inhibitor pp 242 completely ablated mTOR phosphorylation at S2481. TSC2−/− cells were starved and were then treated with 1 pp 242 for two hours. 
         FIG. 8 . Identification of rapamycin-sensitive phosphorylation sites on Grb10. (A) MS/MS experiments identified that phosphorylation of residues S501/S503 of Grb10 is strongly inhibited by rapamycin. (B) Phosphorylation at S455/S458 is rapamycin-insensitive. Sequences, from top to bottom: SEQ ID NO: 1736 and SEQ ID NO: 1737, respectively. 
         FIG. 9 . Phosphorylation of Grb10 at S501/S503 regulates its stability. (A) An antibody showed specificity towards Grb10 phosphorylation at S501/S503. Preincubation of the antibody with the blocking antibody completely eliminated the immunoreactivity. (B) Further validation of the phospho-specific antibody raised against the Grb10 S501/S503 sites. Grb10 WT, S501A/S503A (AA) and S501D/S503D (DD) were transfected into HEK239T cells and were probed with the antibody. Note that this antibody detected wild type (WT) Grb10, but neither of the mutant proteins. (C) Treatment of TSC2−/− cells with various mTOR kinase inhibitors led to Grb10 degradation. (D) Both rapamycin and NVP-BEZ235 treatment led to a decreased level of Grb10 in TSC1−/− cells. (E) Grb10 is highly overexpressed in TSC1−/− cells compared with their wild-type counterparts. (F) rapamycin treatment of TSC2−/− cells stably expressing wild type (WT) Grb10 led to lower levels of both endogenous and exogenous Grb10. 
         FIG. 10 . Grb10 is involved in the feedback loop from mTORC1 to PI3K. (A) Overexpression of Grb10 in HEK293 cells inhibited PI3K activation. W, wild type (WT) Grb10, A, AA mutant and D, DD mutant. Knockdown of Grb10 in TSC2−/− cells led to IRS hyperphosphorylation after insulin stimulation. (B) Overexpression of Grb10 in HEK239 cells suppressed IRS tyrosine phosphorylation and PI3K recruitment after insulin stimulation. HA-tagged Grb10 was transfected and IRS2 immunoprecipitates were analyzed. Phosphorylation at Y612 of IRS was detected. (C) HA-tagged Grb10 was transfected and p85 immunoprecipitates were analyzed. (D) Knockdown of Grb10 in TSC2−/− cells led to increased IRS Y612 phosphorylation upon insulin stimulation. (E) Knockdown of Grb10 in TSC2−/− cells protected these cells against etoposide-induced apoptosis. Cells were starved overnight and were treated with 100 μM etoposide for the indicated times. 
     
    
    
     DEFINITIONS 
     In the tables and the database, *, @, ̂ and # denote phosphorylation (Ser, Thr and Tyr), heavy Lys, heavy Arg and oxidation (Met), respectively. International Protein Index (IPI) reference numbers are given in some of the tables and the database provided herein. The IPI database can be accessed at the European Bioinformatics Institute homepage (www.ebi.ac.uk/), for example, at (www.ebi.ac.uk/IPI/IPIhelp.html). Each IPI database entry provided by accession number is incorporated herein by reference for disclosure of the respective proteins amino acid sequence and accompanying protein information. 
     The term “antibody,” as used herein, refers to an immunoglobulin, whether natural or wholly or partially synthetically produced. All derivatives thereof which maintain specific binding ability are also included in the term. The term also covers any protein having a binding domain which is homologous or largely homologous to an immunoglobulin binding domain. These proteins may be derived from natural sources, or partly or wholly synthetically produced. An antibody may be monoclonal or polyclonal. The antibody may be a member of any immunoglobulin class, including any of the human classes:IgG, IgM, IgA, IgD, and IgE. Derivatives of the IgG class, however, are preferred in the present invention. 
     The term “antibody fragment,” as used herein, refers to any derivative of an antibody which is less than full-length. Preferably, the antibody fragment retains at least a significant portion of the full-length antibody&#39;s specific binding ability. Examples of antibody fragments include, but are not limited to, Fab, Fab′, F(ab′) 2 , scFv, Fv, dsFv, diabody, and Fd fragments. The antibody fragment may be produced by any means. For instance, the antibody fragment may be enzymatically or chemically produced by fragmentation of an intact antibody or it may be recombinantly produced from a gene encoding the partial antibody sequence. Alternatively, the antibody fragment may be wholly or partially synthetically produced. The antibody fragment may optionally be a single chain antibody fragment. Alternatively, the fragment may comprise multiple chains which are linked together, for instance, by disulfide linkages. The fragment may also optionally be a multimolecular complex. A functional antibody fragment will typically comprise at least about 50 amino acids and more typically will comprise at least about 200 amino acids. 
     Single-chain Fvs (scFvs) are recombinant antibody fragments consisting of only the variable light chain (V L ) and variable heavy chain (V H ) covalently connected to one another by a polypeptide linker. Either V L  or V H  may be the NH 2 -terminal domain. The polypeptide linker may be of variable length and composition so long as the two variable domains are bridged without serious steric interference. Typically, the linkers are comprised primarily of stretches of glycine and serine residues with some glutamic acid or lysine residues interspersed for solubility. 
     Diabodies are dimeric scFvs. The components of diabodies typically have shorter peptide linkers than most scFvs, and they show a preference for associating as dimers. 
     An Fv fragment is an antibody fragment which consists of one V H  and one V L  domain held together by noncovalent interactions. The term dsFv is used herein to refer to an Fv with an engineered intermolecular disulfide bond to stabilize the V H -V L  pair. 
     A F(ab′) 2  fragment is an antibody fragment essentially equivalent to that obtained from immunoglobulins (typically IgG) by digestion with an enzyme pepsin at pH 4.0-4.5. The fragment may be recombinantly produced. 
     A Fab fragment is an antibody fragment essentially equivalent to that obtained by reduction of the disulfide bridge or bridges joining the two heavy chain pieces in the F(ab′) 2  fragment. The Fab′ fragment may be recombinantly produced. 
     A Fab fragment is an antibody fragment essentially equivalent to that obtained by digestion of immunoglobulins (typically IgG) with the enzyme papain. The Fab fragment may be recombinantly produced. The heavy chain segment of the Fab fragment is the Fd piece. 
     The term “binding agent”, as used herein, refers to an agent binding a target molecule, for example, a polypeptide comprising a phosphorylation site provided herein, with high specificity. Examples of binding agents are antibodies, antibody fragments, aptamers, and adnectins. 
     The term “phosphosensitive”, as used herein in the context of a binding agent, refers to a binding agent that specifically binds to a phosphorylation site, for example, a phosphorylation site provided herein, in either the phosphorylated or non-phosphorylated state. In some embodiments, a phosphosensitive binding agent provided herein binds to the phosphorylation site in its phosphorylated state, but does not significantly bind the phosphorylation site in a non-phosphorylated state. Phosphosensitive binding agents, for example, phosphosensitive antibodies or antibody fragments, accordingly, allow for the detection of phosphorylation at a specific phosphorylation site. 
     The term “cancer”, as used herein, refers to a malignant neoplastic disease. Most cancers are characterized by hyperproliferation of a cell population. In some embodiments, a cancer manifests as a solid tumor. In some embodiments, a cancer manifests as a liquid tumor. Non-limiting examples of cancers include carcinomas (derived from epithelial cells, e.g., some forms of breast, prostate, lung and colon cancer), sarcomas (derived from connective tissue or mesenchymal cells), lymphoma and leukemia (derived from hematopoietic cells) and seminomas (derived from germ cells). 
     The term “cancer cell”, as used herein, refers to a malignant neoplastic cell. In some embodiments, a cancer cell is part of a neoplastic cell population. In some embodiments, a cancer cell is a cell of a solid tumor. In some embodiments, a cancer cell is a cell of a liquid tumor. In some embodiments, a cancer cell carries a mutation that affects regulation of cell cycle control. In some embodiments, a cancer cell is a cell obtained from a tumor in a subject. 
     The term “candidate agent”, as used herein refers to a molecule to be tested for a specific property, for example, for its ability to inhibit mTOR kinase activity. In some embodiments, a candidate agent is a small molecule. In some embodiments, a candidate agent is a polypeptide or protein. In some embodiments, a candidate agent is a binding agent. In some embodiments, a candidate agent is a nucleic acid. 
     The term “determining a level of expression”, as used herein, refers to performing an assay to determine the level of a gene product expressed in a cell or tissue, for example, in a cancer cell or tumor tissue. In some embodiments, the assay includes obtaining a cell from a subject, for example, by biopsy. In some embodiments, the gene product is a transcript, for example, an mRNA. In other embodiments, the gene product is a protein, for example, an mTOR substrate disclosed herein, or a protein comprising a phosphorylation site disclosed herein. In some embodiments, the gene product is a protein that is phosphorylated at a specific phosphorylation site. In some embodiments, the gene product is a protein that is not phosphorylated at a specific phosphorylation site. Methods, assays, and reagents to determine the level of a gene product in a cell or tissue are described herein and are well known to those of skill in the art. See, for example, Sambrook et al.,  Molecular Cloning , second edition, Cold Spring Harbor Laboratory, Plainview, N.Y.; (1989), or Ausubel et al.,  Current Protocols in Molecular Biology, Current Protocols  (1989), and  DNA Cloning: A Practical Approach , Volumes I and II (ed. D. N. Glover) IREL Press, Oxford, (1985); each of which is incorporated herein by reference. 
     Methods to determine transcript levels include, for example, RT-PCR, northern blot, in situ hybridization, microarray assays, and massive parallel sequencing assays. Methods to determine protein levels include, for example, western blot, immunohistochemistry, ELISA, protein array assays, and mass spectrometry. 
     The term “high risk of expressing an elevated level of PI3K, Akt, and/or MAPK activity”, as used herein in the context of cells, refers to a condition in a cell that is likely to result in upregulation of PI3K, Akt, and/or MAPK kinase activity, when the cell is contacted with a therapeutic agent, for example, with an mTOR inhibitor. The term “risk” is used interchangeably with the term “likelihood” in this context. Such risk can be conferred through feedback-relief triggered by the therapeutic target. For example, in some embodiments, a cell, for example, a cell derived from a tumor in a subject, is determined to have a high likelihood of expressing an elevated level of PI3K, Akt, and/or MAPK, if it is established that the cell highly expresses a feedback-mediator, for example, phosphorylated Grb10, that limits PI3K, Akt, and/or MAPK expression. If the feedback-mediator is a known substrate of an oncogenic kinase, for example, if the feedback-mediator is the mTOR kinase substrate Grb10, then the cell is likely to exhibit feedback relief upon administration of an inhibitor of the kinase, for example, an mTOR kinase inhibitor, which, in turn, may increase the cell&#39;s proliferation and/or survival capacity. 
     The term “inhibitor” as used herein in the context of kinases, refers to a molecule that inhibits the activity of a kinase. In some embodiments, an inhibitor diminishes the catalytic activity of a kinase. In some embodiments, an inhibitor abolishes the catalytic activity of a kinase. In some embodiments, the inhibitor is a small molecule. In some embodiments, the inhibitor is a nucleic acid or a polypeptide. In some embodiments, the inhibitor is a binding agent. In some embodiments, a kinase inhibitor effects inhibition by down-regulating expression of the kinase. In some embodiments, a kinase inhibitor effects inhibition by binding the kinase and interfering with the kinase reaction. In some embodiments, a kinase inhibitor is an allosteric kinase inhibitor. The term “allosteric kinase inhibitor” refers to a kinase inhibitor, for example, a small molecule, that binds its target kinase, wherein the binding of the inhibitor results in an allosteric change in the kinase molecule, leading to diminished kinase activity. Allosteric changes leading to diminished kinase activity can be changes resulting in a reduction of the kinase&#39;s ability to bind a substrate molecule, or changes resulting in a reduction of the kinases ability to transfer a phosphate group to a substrate molecule. In some embodiments, the kinase inhibitor is a catalytic kinase inhibitor. In some embodiments, a catalytic inhibitor, which itself cannot partake in a kinase reaction, competes with a kinase substrate for binding. In some embodiments, a catalytic kinase inhibitor is an ATP-competitive inhibitor. 
     The term “effective amount”, as used herein in the context of kinase inhibitors, refers to an amount of kinase inhibitor sufficient to achieve a measurable inhibition of kinase activity, or an amount of kinase inhibitor sufficient to achieve a clinically desirable outcome. For example, an effective amount of the mTOR inhibitor rapamycin is, in some embodiments, an amount of rapamycin that, when administered to a cell or tissue, results in a measurable decrease in mTOR kinase activity in the cell or tissue. In some embodiments, an effective amount of a kinase inhibitor is an amount that is effective to reduce the activity of the target kinase in a cell or tissue to less than 75%, less than 50%, less than 40%, less than 30%, less than 25%, less than 20%, less than 10%, less than 5%, less than 2.5%, less than 2%, or less than 1% of the activity in the cell or tissue not treated with the inhibitor. Assays for measuring kinase activity are well known in the art and described in more detail elsewhere herein. In some embodiments, an effective amount of a kinase inhibitor, for example, of rapamycin, is an amount that, when administered to a subject, for example, a subject having a cancer with elevated mTOR activity, results in a clinically desirable outcome. In some embodiments, a clinically desirable outcome is reversal of a disease, for example, a decrease in neoplastic or malignant cell number, tumor size, or cell proliferation rate, for example, in a subject having a proliferative disease, e.g., a neoplastic disease or a cancer, or a delay in the progression of a disease, for example a progression from one tumor stage to the next, or from a benign to a malignant neoplastic disease. 
     The term “mTOR kinase inhibitor” as used herein, refers to a molecule inhibiting a kinase activity of the mTOR kinase. Examples of mTOR kinase inhibitors are mTORC1 kinase inhibitors and mTORC1/2 inhibitors. Examples of mTORC1 kinase inhibitors are rapamycin and rapamycin analogs (e.g., Ridaforolimus, Sirolimus or Everolimus). Examples of mTORC1/2 inhibitors are PP242, PP30, AZD8055, OSI-027, WYE354, INK-128, XL388, and torin1. Further examples of mTOR inhibitors are inhibitors that target mTOR and an additional kinase or additional kinases, for example, dual PI3K/mTOR kinase inhibitors (e.g., NVP-BEZ235, BGT-226, XL-765, GSK2126458, or SF1126). 
     The term “PI3K kinase inhibitor”, as used herein, refers to a molecule that inhibits PI3K kinase activity. Examples of PI3K inhibitors are ZSTK474, TGX221, GDC0941, LY294002, XL147, PX147, BKM120, GSK 615, CAL101, and PX-866. 
     The term “mutation”, as used herein, refers to a change in a gene sequence, for example, a deletion, insertion, inversion, transposition, or substitution. In some embodiments, the mutation results in a change of the expression level of the gene product encoded by the respective gene. In some embodiments, a mutation is a mutation in a gene involved in an mTOR signaling pathway, for example, a gene encoding a protein that regulates, directly or indirectly, mTOR kinase activity. Examples of genes involved in an mTOR signaling pathway are Ras, Raf, MAPK, RSK, receptor tyrosine kinases, PI3K (Phosphoinositide 3-kinase), PTEN (phosphatase and tensin homolog), Akt (Protein Kinase B), TSC1/2 (Tuberous sclerosis protein 1, Tuberous sclerosis protein 2, respectively), MEK (Dual specificity mitogen-activated protein kinase kinase 1, MAPK21), LKB (, and NF2 (Neurofibromatosis 2). Methods to determine whether a cell carries a mutation in a gene are well known to those of skill in the related arts. 
     The term “phosphoproteomic profile”, as used herein, refers to a dataset comprising information regarding the level of phosphorylation of a plurality of phosphorylation sites in a biological sample, for example, a proteinaceous sample derived from a cell or tissue sample. Phosphoproteomic profiles of multiple samples can be compared and similarities and dissimilarities in such profiles can be detected and quantified by methods well known to those of skill in the art, including, but not limited to, supervised and non-supervised learning, hierarchical clustering, nearest neighbor analysis. In some embodiments, a phosphoproteomics profile of a clinical sample, for example, of a sample derived from a malignant cell or tissue sample of a subject is compared to a reference sample from healthy cells or tissue, for example, to determine aberrations in protein phosphorylation in the malignant cell or tissue sample. In some embodiments, a phosphoproteomics profile of a clinical sample at issue is compared to phosphoproteomics profiles of clinical samples of known character, for example, to classify the clinical sample at issue. Phosphoproteomic profiles can be classified by methods well known in the art, including the building and application of predictors for the classification. 
     The term “phosphorylation level”, as used herein, refers to the proportion of phosphorylated polypeptides carrying a certain phosphorylation site in a sample relation to all polypeptides carrying the phosphorylation site in the sample. For example, if the total number of polypeptides carrying a specific phosphorylation site in a sample is 10, and 3 of these proteins are phosphorylated at that site, while 7 are not, then the phosphorylation level of this phosphorylation site in the sample would be 30%. Phosphorylation levels can be detected and quantified by methods known to those in the art, for example, by protein detection using phosphosensitive binding agents, e.g., phosphosensitive antibodies or antibody fragments. Most protein quantitation methods known to those of skill in the art do not allow for precise molecule counting, so phosphorylation levels are often approximated based on estimations of the number or fractions of phosphorylated proteins in a sample, for example, after western blot or protein microarray analysis using phosphosensitive antibodies or antibody fragments. 
     The term “phosphorylation site”, as used herein, refers to an amino acid residue within an amino acid sequence, or motif, that can be phosphorylated, for example, by a kinase targeting the respective site. A phosphorylation site is a substrate of a kinase if it can be phosphorylated by that kinase. For example, 5421 and S432 are phosphorylation sites in Grb10 isoform 3 within the motif MSNILSS*QS*PLHPSTLNAVIHR (SEQ ID NO: 4), and are both mTOR substrates, as described elsewhere herein. mTOR phosphorylation sites can further be classified into three classes, as used herein. The term “class I phosphorylation site”, as used herein, refers to a phosphorylation site that is targeted by rapamycin-sensitive mTORC1 activity. The term “class II phosphorylation site,” as used herein, refers to a phosphorylation site that is targeted by rapamycin-insensitive mTORC1 and/or mTORC2 activity. The term “class III phosphorylation site,” as used herein, refers to a phosphorylation site that is targeted by rapamycin-sensitive mTOR activity, rapamycin-insensitive mTOR activity, or both. 
     The term “proliferative disease,” as used herein, refers to any disease in which cell or tissue homeostasis is disturbed in that a cell or cell population exhibits an abnormally elevated proliferation rate. Proliferative diseases include hyperproliferative diseases, such as pre-neoplastic hyperplastic conditions and neoplastic diseases. Neoplastic diseases are characterized by an abnormal proliferation of cells and include both benign and malignant neoplasias. Malignant neoplasia is also referred to a s cancer. 
     The term “reference”, interchangeably used with the term “control” herein, refers to a value, sample, or parameter that serves as a baseline for comparing a value, sample, or parameter of interest to. The use of a reference can be of value in many methods that allow for the detection of absolute levels, for example, of expression, phosphorylation, or protein binding, and is essential in methods that yield semi-quantitative or relative results. Comparing an assay result obtained for a cell or tissue in question, for example, a cell or tissue obtained from a tumor in a subject, to a reference result allows a determination whether the result is abnormal. Depending on their nature, abnormal results can support the inference of specific molecular or cellular aberrations and, in some embodiments, a selection of a course of treatment over another. In some embodiments, a reference value is obtained from cells of the same cell type or the same tissue of origin as the cell in question. For example, in some embodiments, a diseased and a healthy cell is obtained from a subject, and the cells are assayed by methods provided herein in parallel. The value observed in the healthy cell, for example, a level of phosphorylation of a protein then typically serves as the reference level to which the level observed in the cell in question is compared. In other embodiments, the reference level is an average level observed or expected in normal cells. In some embodiments, the reference level is a range typically observed in healthy cells. A suitable reference depends, of course, on the type of assay and sample involved. A suitable reference for a given assay or sample will readily be apparent to those of skill in the art. The following list of exemplary references is for illustration only, since the invention is not limited in this respect. 
     In some embodiments, a suitable reference level, for example, a suitable reference phosphorylation or expression level, is a level observed or expected in a healthy cell or tissue of the same type as the cell or tissue in question. In some embodiments, for example, in some embodiments where a tumor biopsy is assayed, a suitable reference level is a level observed or expected in healthy cells or tissue of the same tissue the tumor originated from, or in cells or tissue adjacent to the tumor. In some embodiments, for example, in some embodiments where a cell is assayed, a reference cell is a healthy cell that is of the same cell type or tissue of origin as the cell in question. In some embodiments, a reference cell is a cell exhibiting normal mTOR kinase activity. In some embodiments, a reference cell is a malignant cell of known phenotype, for example, a malignant cell known to exhibit elevated mTOR kinase activity, a cell known to exhibit elevated mTORC1 kinase activity, or a cell known to exhibit elevated mTORC1/2 kinase activity. In some embodiments, a reference cell is a malignant cell of known phenotype, for example, a rapamycin-sensitive cancer cell or a rapamycin-sensitive cancer cell. 
     In some embodiments, a suitable reference level is an average level calculated or approximated from historic data. In some embodiments, a reference level is a level obtained from a reference cell or tissue assayed in parallel to the cell or tissue in question. In some embodiments, a level obtained from a cell or tissue sample is determined to be different (higher or lower) than the reference level, if it is statistically significantly different (higher or lower) than the reference level. In some embodiments, a level obtained from a cell or tissue sample is determined to be higher than the reference level, if the level is at least about 1.25-fold, at least about 1.5-fold, at least about 2-fold, at least about 3-fold, at least about 5-fold, or at least about 10-fold the reference level. In some embodiments, a level obtained from a cell or tissue sample is determined to be lower than the reference level, if it is less than about 0.75-fold, less than about 0.70-fold, less than about 0.60-fold, less than about 0.50-fold, less than about 0.40-fold, less than about 0.30-fold, less than about 0.25-fold, less than about 0.10-fold, less than about 0.05-fold, or less than about 0.01-fold the reference level. In some embodiments, a level obtained from a cell or tissue is determined to be substantially similar to the reference level, if it is not statistically significantly different from the reference level. In some embodiments, a level obtained from a cell or tissue is determined to be substantially similar to a reference level, if it is within the range of 0.75-fold to 1.25-fold of the reference level. In some embodiments, a profile comprising a plurality of levels obtained from a cell or tissue sample is determined to be substantially similar to a reference profile, if the profiles cluster together in a clustering analysis. In some embodiments, a multi-value profile obtained from a cell or tissue is determined to be substantially similar to a reference profile, if the correlation coefficient between the profiles is at least 0.75, at least 0.8, at least 0.85, at least 0.9, at least 0.91, at least 0.92, at least 0.93, at least 0.94, at least 0.95, at least 0.96, at least 0.97, at least 0.98, or at least 0.99. 
     The term “sample”, as used herein, refers to a biological sample. A biological sample typically comprises a cell or tissue, or biological material derived from a cell or tissue. Examples of biological samples are cell samples and tissue samples obtained from a subject, for example, from a subject having a cancer, cell or tissue cultures, and extracts or preparations obtained from any such samples, for example, protein extracts, isolated proteins or isolated nucleic acids obtained from such samples. 
     A “proteinaceous” sample is a sample comprising proteins or fragments of proteins. In some embodiments, a proteinaceous sample is a sample derived from a cell that includes proteins or fragments of proteins expressed in the cell. In some embodiments, the sample includes a lysed cell. In some embodiments, the sample includes proteins isolated from a cell. In some embodiments, the sample includes an isolated, enriched, or purified protein fraction from a cell, for example, a protein fraction obtained by methods described herein or known to those of skill in the art to separate nucleic acids, carbohydrates, and/or lipids from proteins or fractions of proteins. In some embodiments, the sample is prepared under conditions suitable for obtaining native proteins from a cell. In some embodiments, the sample is prepared under conditions that do not significantly affect native protein phosphorylation patterns. In some embodiments, the sample is prepared under conditions that do not significantly affect the antigenic structure of a phosphorylation site identified herein, for example, a phosphorylation site identified herein to be a target of mTOR kinase activity. In some embodiments, the sample is prepared under conditions suitable for obtaining denatured or fragmented proteins. 
     The term “subject,” as used herein, refers to an individual mammal. In some embodiments, the subject is a human. In some embodiments, the subject is a non-human mammal. In some embodiments, the subject is a non-human primate. In some embodiments, the subject is a rodent. In some embodiments, the subject is a sheep, a goat, a cattle, a cat, or a dog. In some embodiments, the subject is a subject diagnosed to have a cancer. In some embodiments, the subject is a subject diagnosed to have a cancer that exhibits an elevated level of mTOR kinase activity. In some embodiments, the subject is a subject not diagnosed with a cancer. 
     The term “target,” as used herein in the context of kinases, refers to a substrate of a kinase. The term can, accordingly, refer to a protein (e.g., Grb10 is a target of mTOR kinase), to an amino acid sequence comprising a phosphorylation site (e.g., MNILSS*QS*PLHPSTLNAVIHR (SEQ ID NO: 5) or MNILGS*QS*PLHPSTLSTVIHR (SEQ ID NO: 6) are target sequences of mTOR), or to an amino acid residue (e.g. S421 and S423 of mouse Grb10, isoform 3, are targets of mTOR). 
     The term “tumor,” as used herein, refers to a neoplasm or a solid lesion formed by neoplastic cells. A tumor can be benign, pre-malignant, or malignant. In some embodiments, the tumor is a malignant tumor. 
     The term “treatment”, interchangeably used herein with the term “therapy,” as used herein, refers to a clinical intervention aimed to prevent or to ameliorate a disease or condition in a subject. In some embodiments, a treatment is aimed to ameliorate an existing condition, for example, a cancer in a subject. In some embodiments, a treatment is aimed to prevent a condition from occurring or from recurring. For example, in some embodiments, an mTOR kinase inhibitor is administered to a subject having a cancer exhibiting an elevated level of mTOR activity in order to inhibit cell proliferation in the malignant cells. For another example, in some embodiments, an mTOR kinase inhibitor is administered to a subject having a cancer exhibiting an elevated level of mTOR activity after a malignant tumor has been removed from the subject, in order to prevent or delay recurrence of the disease. The foregoing examples are non-limiting, and those of skill in the art will readily envision further scenarios of treatment as the invention is not limited in this respect. Some embodiments include a choice of treatment, referring to a selection of a clinical intervention from a number of alternatives, or to a design of a clinical intervention to meet the specific needs of an individual subject. In some embodiments, a choice of treatment involves the design of a personalized therapeutic approach for a subject having a cancer exhibiting elevated mTOR activity based on the results from diagnostic methods provided herein. For example, in some embodiments, a choice of treatment includes administering to a subject having cancer a specific mTOR inhibitor in combination with an additional kinase inhibitor targeting an mTOR feedback-inhibited pathway based on a determination that cancer cells in the subject exhibit high mTOR activity and elevated levels of a feedback-inhibitor targeted by mTOR in order to avoid feedback relief. In some embodiments, a choice of treatment includes the determination of an appropriate treatment. Some embodiments further include carrying out the selected treatment. 
     DETAILED DESCRIPTION OF CERTAIN EMBODIMENTS 
     This invention relates to the identification of proteins and sites on those proteins that are phosphorylated by mTOR kinase. Some aspects of this invention relate to the surprising discovery that some proteins that are substrates of mTOR kinase regulate mTOR upstream signaling pathways, thus providing feedback regulatory circuits. Some aspects of this invention relate to methods of classifying cells, for example, neoplastic cells or cancer cells, based on the phosphorylation status of mTOR targets. Some aspects of this invention relate to methods of personalized treatment of subjects having a proliferative disease, for example, a neoplastic disease or a cancer, exhibiting elevated mTOR signaling based on the phosphorylation status of mTOR targets in the diseased cells. Other aspects of this invention relate to methods and materials for the generation of phosphoproteomics profiles that include phosphorylation data for a plurality of mTOR targets. Some aspects of this invention relate to classification of cells or tissues, for example, tumor cells or tissues, based on phosphoproteomic data, for example, based on phosphoproteomic profiles of the cells or tissues. Some aspects of this invention relate to methods of identifying mTOR kinase inhibitors by identifying compounds able to interfere with mTOR kinase activity towards one or more of the mTOR targets provided herein. Some aspects of this invention relate to the identification of Grb10 as a target of mTOR kinase activity, and to methods for determining the level of mTOR activity in a cell based on Grb10 phosphorylation status. Some aspects of this invention relate to the surprising discovery that Grb10 is not only a target of mTOR kinase activity, but also an inhibitor of PI3K kinase activity. Since PI3K is a positive regulator of mTOR kinase activity, Grb10 has been identified as a mediator of mTOR feedback inhibition herein. Other aspects of this invention relate to the surprising discovery that Grb10 and PTEN mutations are mutually exclusive in certain types of tumor cells. Accordingly, some aspects of this invention relate to the surprising discovery that Grb10 is a tumor suppressor and that Grb10 phosphorylation is a useful biomarker for determining mTOR kinase activity in cells, and particularly in tumor cells. Other aspects of this invention relate to methods and reagents useful for determining the phosphorylation status of a protein or phosphorylation site identified to be an mTOR target herein. For example, some aspects of this invention provide phosphosensitive antibodies or antibody fragments specifically binding an mTOR kinase target site identified herein in either the phosphorylated or the non-phosphorylated state, thus allowing for a determination of the phosphorylation state of such a site in a cell. 
     mTOR Target Proteins and Sites
 
Identification of mTOR Target Sites
 
     Some aspects of this invention relate to the identification of proteins and phosphorylation sites thereon as downstream targets of mTOR kinase activity. Targets of mTOR kinase activity are provided in Tables 1 and 2. 
     Classification of mTOR Targets 
     Some aspects of this invention relate to the classification of mTOR target phosphorylation sites provided herein as class I (targets of rapamycin-sensitive mTORC1 kinase signaling), class II (targets of rapamycin-insensitive mTORC1 or mTORC2 signaling), and class III (targets of both rapamycin-sensitive and rapamycin-insensitive mTOR signaling) phosphorylation sites. 
     This classification is useful to determine the type(s) of mTOR signaling exhibited by a cell or tissue and can support a classification of cells that are targeted for therapy, for example, of cancer cells. For example, in some embodiments, the phosphorylation status of an mTOR target is determined in a cancer cell obtained from a subject with a cancer exhibiting elevated mTOR kinase activity. Classification of the type of mTOR signaling can, in some embodiments, be a basis for the selection of an appropriate therapeutic approach. For example, if it is determined that a class I target of mTOR signaling is phosphorylated, then the elevated mTOR kinase activity is rapamycin-sensitive mTORC1 kinase activity. In some such embodiments, a method of treatment is then typically selected that includes administration of an inhibitor of rapamycin-sensitive mTORC1 signaling, for example, rapamycin or a rapamycin analog. 
     To give but another example: if it is determined that a class II target of mTOR signaling is phosphorylated, then the elevated mTOR kinase activity is rapamycin-insensitive mTORC1 or mTORC2 kinase activity. In some such embodiments, a method of treatment is then typically selected that includes administration of an mTORC1/2 inhibitor as provided herein. In some embodiments where class I targets of mTOR signaling are found to not be phosphorylated, a method of treatment is typically selected that does not include administration of an mTORC1 inhibitor. 
     To give a third example: if it is determined that a class III target of mTOR signaling is phosphorylated, then a method of treatment is selected that includes administration of an mTORC1 inhibitor and an mTORC1/2 inhibitor as provided herein. In some embodiments, a method of treatment that includes administering an mTORC1 inhibitor or an mTORC1/2 inhibitor alone may be inappropriate. 
     Further, some aspects of this invention provide methods to analyze gene ontology distributions in sets of mTOR targets, for example, in order to determine whether a specific signaling pathway is targeted by mTOR in a given cell, or a given therapeutic or experimental scenario. 
     Exemplary Proteins Identified in the Rapamycin Phosphoproteomic Screen as Targets of mTORC1 Signaling. 
     The phosphoproteomic screen described herein identified numerous proteins as mTOR targets, for example, as mTORC1 targets. As described in more detail elsewhere herein, the expression, expression level, phosphorylation, or phosphorylation level of one or more of such mTOR target proteins, for example, the proteins described in any of tables 1-3, or the level of phosphorylation of their respective phosphorylation sites, is employed, in some embodiments, as a biomarker for monitoring or diagnosing disease. In some embodiments, the mTOR target proteins disclosed herein, for example, the mTORC1 target proteins described in any of tables 1-3, are used in pharmaceutical screens as drug targets for the development of drugs modulating mTOR pathway downstream effects. Some exemplary mTORC1 target proteins identified herein are described in more detail below. These descriptions of exemplary mTOR target proteins are for illustration of some aspects of this disclosure and are not meant to limit the scope of the invention. Grb10, one of the mTORC1 protein targets identified in the phosphoproteomics screen, is described in more detail elsewhere herein. Briefly, Grb10, also known as growth factor receptor-bound protein 10, is stabilized by mTORC1-mediated phosphorylation, which, in turn, results in feedback inhibition of the PI3K and MAPK pathways. This is consistent with Grb10 expression being frequently downregulated in a variety of cancers. Grb10 is a tumor suppressor with relevance across a broad spectrum of cancer subtypes, and the identification of Grb10 as an mTORC1 substrate links mTORC1 activity to cancers with aberrantly low Grb10 expression or stability. Accordingly, some embodiments provide Grb10 phosphorylation as a biomarker for mTORC1 activity in a cell, tissue, or sample of interest. Methods of using Grb10 expression or phosphorylation assays to monitor mTORC1 activity in a cell, tissue, or sample of interest are also provided. For example, some embodiments provide a method of monitoring the efficacy of a drug on mTORC1 activity in a cell, tissue, or sample, by measuring Grb10 expression or phosphorylation levels. In some embodiments, such assessments are used to diagnose or monitor a disease associated with aberrant levels of mTORC1 activity, for example, cancer, or to adjust a drug dosage, for example, to the minimal dosage necessary to achieve a target mTORC1 activity level, or to choose a suitable drug modulating mTORC1 activity from a plurality of drugs, for example, the drug that shows the highest efficacy at a given dose. 
     Some of the mTORC1 protein targets identified herein are potential regulators of gene expression. For example, FOXK1 (Forkhead box protein K1), also known to those of skill in the art as MNF, or MNF (myocyte nuclear factor)-beta, is a winged-helix protein expressed selectively and transiently in myogenic precursor cells of the heart and skeletal muscles, and collaborates with proteins of the mammalian Sin3 (mSin3) family to repress transcription. Mutated forms of MNF-beta that fail to bind mSin3 are defective in transcriptional repression and in negative growth regulation, an overexpression phenotype revealed in oncogenic transformation assays. These phenotypic traits associated with MNF-beta dysfunction are consistent with the mTORC1 phenotype. 
     For another example, ZEB2 (Zinc finger E-box-binding homeobox 2) belongs to the ZEB family of zinc finger transcription factors, which are essential regulators of gene expression during normal embryonic development. ZEB proteins induce epithelial to mesenchymal transition (EMT), a process in which epithelial cells become migratory mesenchymal cells. E-cadherin is a major target gene of ZEB transcriptional repressors, and e-cadherin downregulation is considered a hallmark of EMT. In recent years, the involvement of the ZEB proteins in pathological contexts has been documented as well. For example, ZEB proteins play an important role in mediating Ras-induced EMT in breast epithelial cells. Mutations in ZEB encoding genes cause severe syndromic malformations, and are implicated in malignant tumor progression. Without wishing to be bound by theory, ZEB2 is believed to be a critical target in lymphangioleiomyomatosis (LAM) that represents the point of convergence of the mTORC1 and ERK-MAP kinase pathways that are critical to this disease. 
     For another example, NDRG3 is the downstream target of N-Myc. Phosphorylation of NDRG3 links mTOR signaling pathway to Myc activity as an oncogenic transcription factor. 
     Accordingly, some embodiments provide FOXK1, ZEB2, and/or NDRG3 phosphorylation as a biomarker for mTORC1 activity in a cell, tissue, or sample of interest. Methods of using FOXK1, ZEB2, and/or NDRG3 expression or phosphorylation assays and levels useful for monitoring mTORC1 activity in a cell, tissue, or sample of interest are also provided. For example, some embodiments provide a method of monitoring the efficacy of a drug on mTORC1 activity in a cell, tissue, or sample, by measuring FOXK1, ZEB2, and/or NDRG3 expression or phosphorylation levels. In some embodiments, such assessments are used to monitor or diagnose a disease associated with aberrant mTORC1 activity, as manifest by aberrant FOXK1, ZEB2, and/or NDRG3 phosphorylation level(s), and/or to adjust a drug dosage, for example, to the minimal dosage necessary to achieve a target mTORC I activity level, or to choose a suitable drug modulating mTORC1 activity from a plurality of drugs, for example, the drug that exhibits the highest efficacy at a given dose. 
     Some of the mTORC1 protein targets identified herein are regulators of mRNA synthesis, mRNA processing, and protein synthesis. This is consistent with the role mTORC1 activity plays in the control of cell growth, which, if improperly regulated, can contribute to tumor genesis and/or growth. For example, LARP1 binds mRNA in vitro via both the La motif and the LARP1 domain. LARP-1 also down-regulates the Ras-MAPK pathway. Accordingly, without wishing to be bound by any particular theory, LARP1 phosphorylation represents an mTORC1-dependent regulation of this feedback loop. The LARP-1 protein colocalizes with P bodies, which function in RNA degradation, and it is believed that the cluster of LARP-1 homologs functions to control the expression of key developmental regulators. Without wishing to be bound by any particular theory, some aspects of this invention provide that LARP-1 functions in P-bodies to attenuate the abundance of Ras-MAPK pathway-regulated mRNAs. 
     For another example, EDC3 is associated with an mRNA-decapping complex required for removal of the 5′-cap from mRNA prior to its degradation from the 5″-end. 
     For another example, SRPK2 is involved in SR protein phosphorylation, which influences other aspects of mRNA metabolism, such as splice site selection (alternative splicing), mRNA export, nonsense-mediated decay (NMD), and translation efficiency. Accordingly, some aspects of this disclosure provide that SRPK2 links mTOR/S6K signaling to SR protein activity. 
     Another example of an MTORC1 target identified herein that regulates mRNA synthesis and processing is CDK12-(CDC2-related kinase, arginine/serine-rich). CDK12 is involved in the regulation of alternative mRNA splicing. Without wishing to be bound by any particular theory, it is believed that, similar to SRPK2, CDK12 is also involved in regulating mRNA splicing by mTOR signaling. A CDK12-binding partner, cyclin-L1 (CCNL1), is also identified as an mTORC1 target protein herein. Without wishing to be bound by any particular theory, similar to SRPK and CDK12, CCNL1 may contribute to mRNA biogenesis and cell proliferation. 
     Accordingly, some embodiments provide LARP1, SRPK2, and/or CDK12 phosphorylation as a biomarker for mTORC1 activity in a cell, tissue, or sample of interest. Methods of using LARP1, SRPK2, and/or CDK12 expression or phosphorylation levels to monitor mTORC1 activity in a cell, tissue, or sample of interest are also provided. For example, some embodiments provide a method of monitoring the efficacy of a drug on mTORC1 activity in a cell, tissue, or sample, by measuring LARP1, SRPK2, and/or CDK12 expression or phosphorylation levels. In some embodiments, such assessments are used to monitor or diagnose a disease associated with aberrant mTORC1 activity, as manifest by aberrant LARP1, SRPK2, and/or CDK12 phosphorylation level(s), and/or to adjust a drug dosage, for example, to the minimal dosage necessary to achieve a target mTORC1 activity level, or to choose a suitable drug modulating mTORC1 activity from a plurality of drugs, for example, the drug that exhibits the highest efficacy at a given dose. 
     Another example of an mTORC1 target protein identified herein is MIB1, an E3 ubiquitin-protein ligase that has been reported to ubiquinate Notch, which leads to the degradation of Notch. Accordingly, some aspects of this disclosure provide that mTORC1 activity is linked to Notch signaling via phosphorylation of MIB1. Yet another example of an mTORC1 target protein identified herein is IBTK (Isoform 2 of Inhibitor of Bruton tyrosine kinase), which is a protein tyrosine kinase implicated in the primary immunodeficiency disease X-linked agammaglobulinemia (Bruton agammaglobulinemia). IBTK is activated upon binding to PIP3 generated as a result of PI3K activation. Without wishing to be bound by any particular theory, phosphorylation of IBTK affects IBTK&#39;s ability to inhibit PI3K kinase activity. Accordingly, some embodiments of this invention are based on the recognition that there is a link between the mTORC1 signaling system and the regulation of tyrosine phosphorylation. 
     Accordingly, some embodiments provide MIB1 and/or IBTK phosphorylation as a biomarker for mTORC1 activity in a cell, tissue, or sample of interest. Methods of using MIB1 and/or IBTK expression or phosphorylation assays to monitor mTORC1 activity in a cell, tissue, or sample of interest are also provided. For example, some embodiments provide a method of monitoring the efficacy of a drug on mTORC1 activity in a cell, tissue, or sample, by measuring MIB1 and/or IBTK expression or phosphorylation levels. In some embodiments, such assessments are used to monitor or diagnose a disease associated with aberrant mTORC1 activity, as manifested by aberrant MIB1 and/or IBTK phosphorylation level(s), and/or to adjust a drug dosage, for example, to the minimal dosage necessary to achieve a target mTORC1 activity level, or to choose a suitable drug modulating mTORC1 activity from a plurality of drugs, for example, the drug that exhibits the highest efficacy at a given dose. 
     Representative protein sequences of Grb10, FOXK1, ZEB2, NDRG3, LARP1, SRPK2, CDK12, MIB1, IBTK, and other proteins identified herein to be mTORC1 substrates, can be found under the respective database entries provided in the tables and the database provided herein, and, for example, in the NCBI database under accession numbers NP — 001171100.1 (growth factor receptor-bound protein 10 (Grb10) isoform 2,  Mus musculus , SEQ ID NO: 1720), NP — 034475.2 (growth factor receptor-bound protein 10 (Grb10) isoform 1,  Mus musculus , SEQ ID NO: 1721), NP — 001001550.1 (growth factor receptor-bound protein 10 (Grb10) isoform c, SEQ ID NO: 7), NP — 005302.3 (Grb10 isoform a, SEQ ID NO: 8) and NP — 001001549.1 (Grb10 isoform b, SEQ ID NO: 9); NP — 001032242.1 (FOXK1, SEQ ID NO: 10); NP — 001165124.1 and NP — 055610.1 (ZEB2, SEQ ID NO: 11 and SEQ ID NO: 12, respectively); NP — 071922.2 and NP — 114402.1 (NDRG3, SEQ ID NO: 13 and SEQ ID NO: 14, respectively); NP — 056130.2 (LARP1, SEQ ID NO: 15); NP — 872633.1 and NP — 872634.1 (SRPK2, SEQ ID NO: 16 and SEQ ID NO: 17, respectively); NP — 055898.1 and NP — 057591.2 (CDK12, SEQ ID NO: 18 and SEQ ID NO: 19, respectively); NP — 065825.1 (MIB1, SEQ ID NO: 20); and NP — 056340.2 (IBTK, SEQ ID NO: 21). These database entries are incorporated herein by reference for disclosure of representative sequences of the respective proteins. 
     Feedback Circuitry Involving mTOR Targets 
     Some aspects of this invention relate to the surprising discovery that some mTOR target proteins are involved in feedback loops of mTOR signaling, for example, by inhibiting upstream modulators of mTOR signaling, such as PI3K, Akt, and MAPK, after being phosphorylated as a result of mTOR kinase activity. Some aspects of this invention relate to the surprising discovery that relief of feedback inhibition of cellular pro-survival, pro-proliferation signaling by mTOR downstream targets, for example, by Grb10, can contribute to rapamycin resistance or even clinically detrimental outcome in the treatment of neoplastic disease (e.g., cancer) with mTOR inhibitors. Some aspects of this invention relate to the identification, for the first time, of Grb10 as a target of mTOR kinase activity. Grb10, growth factor receptor-bound protein 10, is a protein well known to those of skill in the art. Representative protein sequences of Grb10 can be found under the respective database entries provided in the tables and the database provided herein, and, for example, in the NCBI database under accession numbers NP — 001001550.1 (growth factor receptor-bound protein 10 isoform c), NP — 005302.3 (isoform a) and NP — 001001549.1 (isoform b). These database entries are incorporated by reference for disclosure of representative Grb10 sequences. 
     Feedback Inhibition of PI3K by Grb10 
     Some aspects of this invention relate to the surprising discovery that Grb10 is not only a target of mTOR kinase activity, but also a mediator of mTOR feedback inhibition and, thus, a tumor suppressor gene. As described in more detail elsewhere herein, mTOR-mediated phosphorylation of Grb10 results in stabilization and/or prevention of degradation of Grb10. Grb10, in turn, inhibits PI3K kinase activity. PI3K kinase activity targets mTOR and activates mTOR signaling. Accordingly, as provided by some aspects of this invention, treatment of a cancer exhibiting an elevated level of Grb10 phosphorylation can lead to relief of the Grb10-mediated feedback inhibition of PI3K. PI3K signaling, however, promotes proliferation and survival, and aberrant PI3K activity is known to contribute to carcinogenesis. The discovery that some mTOR targets identified herein, for example, Grb10, mediate a feedback inhibition of pro-survival and pro-proliferation signaling (e.g. PI3K, Akt, and MAPK signaling) in cancer cells, could explain why some types of cancer exhibiting elevated levels of mTOR activity do not respond favorably to treatment with an mTORC1 inhibitor (e.g., rapamycin) alone. The mTORC1 inhibitor may cause relief of the feedback inhibition which may, in turn result in sustained survival and proliferation, and even an increase or acceleration in disease progression or recurrence, as observed in some clinical trials of cancer treatment with mTOR inhibitors. 
     Also provided herein are methods of treating a cancer determined to exhibit an elevated level of Grb10 phosphorylation. In some embodiments, the method comprises administering to the subject an mTOR inhibitor and, additionally, an agent that stabilizes Grb10 or that inhibits the degradation of Grb10. In some embodiments, the method comprises effecting an inhibition of Grb10 degradation by administering a compound that inhibits Grb10 degradation. In some embodiments, the compound that inhibits Grb10 degradation is a ubiquitin ligase inhibitor, for example, a ubiquitin E3 ligase inhibitor. In some embodiments, the method comprises administering to the subject an mTOR inhibitor and, additionally, a PI3K inhibitor. PI3K inhibitors are known to those of skill in the art and described in more detail elsewhere herein. 
     Diagnostic Methods 
     Classification of Cancer Cells Based on Grb10 Phosphorylation 
     Some aspects of this invention provide methods for the classification of a neoplastic disease, for example, a cancer, based on the phosphorylation status of Grb10. In some embodiments, a method is provided that includes obtaining a neoplastic cell from a subject diagnosed to have a cancer, determining the level of Grb10 phosphorylation in the cell, and comparing the level of Grb10 phosphorylation to a reference level. In some embodiments, if the level of Grb10 phosphorylation in the cell is higher than the reference level, then the cell is determined to exhibit an elevated level of mTOR kinase activity. In some embodiments, the cell is determined to exhibit an elevated level of mTORC1 kinase activity based on an elevated level of Grb10 phosphorylation. 
     Methods of determining a level of protein phosphorylation, for example, of Grb10 phosphorylation, are well known to those of skill in the art. Exemplary methods as well as materials useful for such methods are described, for example, in Marjo de Graauw (Editor),  Phospho - Proteomics: Methods and Protocols  ( Methods in Molecular Biology ), Humana Press; 1 edition (2009), ISBN-10: 1603278338. Phosphosensitive binding agents, for example, phosphosensitive antibodies, are provided herein, are commercially available, or can be obtained by those of skill in the art with no more than routine experimentation. 
     Such methods include, for example, detection of phosphorylated protein with a phosphosensitive antibody and comparison of the amount of phosphorylated protein detected to the total amount of the protein in a sample. Other methods for quantitative or semi-quantitative detection of phosphorylated protein will be apparent to those of skill in the art and the invention is not limited in this respect. 
     In some embodiments, a method is provided that includes selecting a method of treatment of a neoplastic disease, for example, a cancer based on a cell from a subject having the disease exhibiting an elevated level of Grb10 phosphorylation. In some embodiments, an elevated level of Grb10 phosphorylation is indicative of an elevated level of rapamycin-sensitive mTORC1 kinase activity in the cell. In some embodiments, a method of treatment is chosen based on the cell exhibiting an elevated level of Grb10 phosphorylation that includes administration of an mTORC1 inhibitor, for example, a rapamycin or a rapamycin analog. 
     Classification of Cancer Cells Known to Exhibit Elevated Levels of mTOR Activity 
     Some aspects of this invention relate to the discovery that the mTOR target Grb10 is an inhibitor of the mTOR upstream regulators, PI3K, Akt, and MAPK, and, thus, can be characterized as a tumor suppressor gene and an mTOR feedback inhibitor. Some aspects of this invention provide a method for selecting a treatment of a cancer known to exhibit an elevated mTOR kinase activity based on the expression level of the mTORC1 target Grb10. In some embodiments, the method comprises obtaining a cancer cell from a subject diagnosed to have a cancer exhibiting an elevated level of mTOR activity, determining the level of Grb10 expression in the cell, and comparing the level of Grb10 expression to a reference level. In some embodiments, if the level of Grb10 expression in the cancer cell is higher than the reference level, then the cell is determined to exhibit a high likelihood of expressing an elevated level of PI3K, Akt, and/or MAPK activity upon being contacted with an mTORC1 inhibitor. In some embodiments, elevated expression of Grb10 supports the conclusion that upon treatment of the cell or a population of cells of the same type, mTORC1-dependent phosphorylation of Grb10 will be decreased or abolished, resulting in rapid ubiquitination and degradation of Grb10 protein, and, subsequently, in a relief of the Grb10-mediated feedback inhibition of PI3K, as described herein. This relief of feedback inhibition may, in some embodiments, result in elevated PI3K signaling. In some embodiments, elevated PI3K in a cancer cell is an undesirable response to treatment of a subject because it can lead to increased cell proliferation and/or survival, thus offsetting or even outweighing the beneficial effect of the administered mTORC1 inhibitor. 
     Measuring the expression level of an mTOR target protein can be achieved by using methods well known to those of skill in the art, including, but not limited to, protein expression assays, for example, immunostaining methods (e.g., western blot, protein microarray, immunohistochemistry, phosphoproteomic assays using phosphosensitive binding agents), ELISA, transcript expression assays, for example, RT-PCR, massive parallel sequencing assays, microarray assays, northern blot, or in situ hybridization. Other suitable methods will be apparent to those of skill in the art and the invention is not limited in this respect. See, for example, Sambrook et al., Molecular Cloning, second edition, Cold Spring Harbor Laboratory, Plainview, N.Y.; (1989); Ausubel et al.,  Current Protocols in Molecular Biology , Current Protocols (1989), and DNA Cloning: A Practical Approach, Volumes I and II (ed. D. N. Glover) IREL Press, Oxford, (1985); and  Current Protocols in Molecular Biology , Wiley Publishing, accessible at www.currentprotocols.com; each of which is incorporated herein by reference. 
     In some embodiments, after a cancer cell is classified, a method of treatment of the subject from which the cell was obtained is selected based on the cancer cell exhibiting a high likelihood of expressing an elevated level of PI3K, Akt, and/or MAPK activity upon being contacted with an mTORC1 inhibitor. In some embodiments, the method of treatment comprises administering an effective amount of an mTOR kinase inhibitor and, additionally, an effective amount of an IGF1R, EGFR, PI3K, Akt, MEK, or RSK inhibitor, or a combination thereof. In some embodiments, the method of treatment comprises administering an effective amount of an mTOR kinase inhibitor and, additionally, of a compound stabilizing Grb10 to the subject. In some embodiments, the mTOR kinase inhibitor is an mTORC1 inhibitor, for example, rapamycin or a rapamycin analog. In some embodiments, the selected method of treatment is communicated to the subject, to a physician or other health care professional treating the subject. In some embodiments, the selected method of treatment is carried out. 
     Determining and Classifying mTOR Activity in a Cell Based on Phosphoproteomics 
     Some aspects of this invention provide methods for determining the level of mTOR activity in a cell based on analysis of the phosphorylation state of one or more mTOR targeted phosphorylation sites as provided herein. Some aspects of this invention provide methods to determine a class of mTOR signaling, for example, rapamycin-sensitive mTORC1 signaling, rapamycin-insensitive mTORC1 or mTORC2 signaling, or rapamycin-sensitive and/or rapamycin-insensitive mTOR signaling, in a cell based on an analysis of the phosphorylation state of a phosphorylation site as provided herein. 
     Methods useful for the determination of the phosphorylation level of a phosphorylation site in a cell are known to those of skill in the art. In some embodiments, such methods comprise obtaining a proteinaceous extract from the cell under conditions that allow for protein phosphorylation to be preserved with high fidelity. In some embodiments, such methods comprise contacting the cell extract with a phosphosensitive binding agent or with a plurality of phosphosensitive binding agents, for example, phosphosensitive antibodies or antibody fragments. 
     The invention provides phosphosensitive antibodies and antibody fragments to the phosphorylation sites described in the tables and the database. For example, phosphosensitive mTORC1 downstream effector antibodies, including, but not limited to, anti-phospho-NDRG3 (Ser331), anti-phospho-S501/503-Grb10, Anti-CDC2-related Kinase, Arg/Ser-Rich (Ser437), In some embodiments, antibodies provided herein are developed in rabbits. Other phosphosensitive antibodies are described elsewhere herein. 
     Phosphosensitive antibodies are useful in some embodiments to determine the phosphorylation level of one or more phosphorylation sites disclosed herein. One non-limiting example of such an embodiment is a phosphosensitive protein microarray assay. In some embodiments, the cell extract is contacted with a single phosphosensitive binding agent. In some embodiments, the cell extract is contacted with a plurality of binding agents in parallel. In some such embodiments, the cell is contacted with a microarray comprising a plurality of phosphosensitive binding antibodies or antibody fragments immobilized on a solid surface, for example, a glass surface. Phosphoproteomic assays, arrays, binding agents, and methods for sample preparation and analysis are well known in the art, and exemplary methods are described, for example, in Marjo de Graauw (Editor),  Phospho - Proteomics: Methods and Protocols  ( Methods in Molecular Biology ), Humana Press; 1 edition (2009), ISBN-10: 1603278338. The foregoing reference is incorporated herein by reference in its entirety for disclosure of methods and materials useful for the determination of the phosphorylation state of a phosphorylation site on a protein in a cell, tissue, or biological sample. 
     In some embodiments, the method comprises determining the level of phosphorylation of a phosphorylation site of a protein disclosed in Tables 1 or 2, and comparing the level of phosphorylation to a reference level. If the level of phosphorylation in the cell is higher than the reference level, then the cell is determined to exhibit an elevated level of mTOR kinase activity. If the level of phosphorylation in the cell is equal or lower than the reference level, then the cell is determined to not exhibit an elevated level of mTOR kinase activity. Methods of determining a level of phosphorylation are provided herein, and additional suitable methods will be apparent to those of skill in the art. The invention is not limited in this respect. 
     Suitable reference levels and methods of determining a reference level will be apparent to those of skill in the art. For example, if the cell is a neoplastic cell or cancer cell obtained from a subject, for example form a biopsy of a solid tumor in the subject, a suitable reference level may be obtained, in some embodiments, from a cell obtained from healthy or non-malignant tissue adjacent to the solid tumor, or a healthy cell of the same tissue of origin as the tumor cells from the same subject or from a different subject. If the cell is obtained from a healthy subject, a suitable reference level may be obtained from a cell of the same cell type obtained from another healthy subject. In some embodiments, a suitable reference level may be an average level or a range of levels observed or expected in cells obtained from healthy subjects that are of the same cell type of the same tissue of origin as the cell in question. In some embodiments, a reference level is a historical level, based on experience or prior experiments, or a level published or otherwise known in the art. Other suitable reference levels are described elsewhere herein and additional reference levels and methods to obtain such levels will be apparent to those of skill in the art. 
     In some embodiments, a plurality of phosphorylation sites are assayed including a Grb10 phosphorylation site, a pNDRG3 phosphorylation site, a CDK12 phosphorylation site, a FOXK1 phosphorylation site, a ZEB2 phosphorylation site, a LARP I phosphorylation site, an MIB1 phosphorylation site, an IBTK phosphorylation site, and/or a SRPK2 phosphorylation site. In some embodiments, a group of phosphorylation sites of proteins involved in a specific biological pathway are assayed, for example, of proteins known to those of skill in the art to be involved in a biological pathway disclosed in Table 10. In some embodiments, the plurality of phosphorylation sites includes mTOR target sites that were previously known. In some embodiments, the plurality of phosphorylation sites comprises at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 25, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90, or at least 100 phosphorylation sites disclosed in Table 1. In some embodiments, the plurality of phosphorylation sites comprises at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 25, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90, or at least 100 phosphorylation sites disclosed in Table 2. In some embodiments, the plurality of phosphorylation sites comprises at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 25, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90, or at least 100 phosphorylation sites disclosed in Table 3 or in replicate described therein. In some embodiments, the plurality of phosphorylation sites comprises at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 25, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90, or at least 100 phosphorylation sites disclosed in Table 7 or in replicate described therein. In some embodiments, the plurality of phosphorylation sites comprises at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 25, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90, or at least 100 phosphorylation sites disclosed in Table 8. In some embodiments, the plurality of phosphorylation sites comprises at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, at least 25, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90, or at least 100 phosphorylation sites disclosed in Table 11, or in any Rapa or Ku replicate therein 
     In some embodiments, if a phosphorylation site determined to exhibit a higher level of phosphorylation in a cell in question, for example, a cancer cell obtained from a subject, as compared to a reference level is a class I phosphorylation site, then the cell is determined to exhibit an elevated level of rapamycin-sensitive mTORC1 activity. In some embodiments, if a phosphorylation site determined to exhibit a higher level of phosphorylation in the cell as compared to the reference level is a class II phosphorylation site, then the cell is determined to exhibit an elevated level of rapamycin-insensitive mTORC1 and/or mTORC2 activity. In some embodiments, if a phosphorylation site determined to exhibit a higher level of phosphorylation in the cell as compared to the reference level is a class III phosphorylation site, then the cell is determined to exhibit an elevated level of rapamycin-sensitive mTOR activity, or an elevated level of rapamycin-insensitive mTOR activity, or both. In some embodiments, if a cell is determined to exhibit a higher level of phosphorylation at phosphorylation sites of more than one class, then the cell is determined to exhibit a combination of elevated levels of mTOR signaling of the respective type. 
     In some embodiments, a method is provided comprising selecting a method of treatment based on the level of phosphorylation of the phosphorylation site(s) assayed. In some embodiments, if the cell is determined to exhibit an elevated level of mTOR kinase activity, then a method of treatment is selected that comprises administering an effective amount of an mTOR kinase inhibitor to the subject. In some embodiments, if the cell is determined to not exhibit an elevated level of mTOR kinase activity, then a method of treatment is selected that does not include administering an mTOR kinase inhibitor. In some embodiments, a method is provided that comprises selecting a method of treatment based on the classification of mTOR target sites that are determined to exhibit an elevated level of phosphorylation in the cell. For example, in some embodiments, if the cell is determined to exhibit an elevated level of rapamycin-sensitive mTORC1 activity, then a method of treatment is selected that comprises administering an effective amount of an inhibitor of rapamycin-sensitive mTORC1 kinase activity to the subject. In some embodiments, if the cell is determined to exhibit an elevated level of rapamycin-insensitive mTORC1 and/or mTORC2 activity, then a method of treatment is selected that comprises administering an effective amount of an inhibitor of rapamycin-insensitive mTORC1 kinase activity to the subject. In some embodiments, if the cell is determined to exhibit an elevated level of rapamycin-sensitive mTOR kinase activity, or an elevated level of rapamycin-insensitive mTOR kinase activity, or both, then a method of treatment is selected that comprises administering an effective amount of an inhibitor of rapamycin-sensitive and rapamycin-insensitive mTOR kinase activity or a combination of an inhibitor of rapamycin-sensitive mTOR kinase activity and an inhibitor of rapamycin-insensitive mTOR kinase activity to the subject. 
     Classification of a Cancer Based on Grb10 and/or PTEN Expression Levels 
     Some aspects of this invention relate to the surprising discovery that mutations leading to loss of function of the tumor suppressor Grb10 and mutations leading to loss of function of the tumor suppressor PTEN, are mutually exclusive. Loss of function of either tumor suppressor leads to elevated PI3K activity, which is thought to significantly contribute to carcinogenesis in certain types of cancer. In some embodiments, a method is provided that allows for the classification of a cancer based on Grb10 or PTEN expression levels. In some embodiments, the method comprises determining the level of expression of Grb10 in a cancer cell. In some embodiments, the method comprises determining the level of expression of PTEN in a cancer cell. In some embodiments, the method comprises determining the level of expression of Grb10 and PTEN in a cancer cell. 
     Expression levels of Grb10 and PTEN can be determined by various methods known to those of skill in the art including, for example methods for determining a level of protein, methods for determining a level of mRNA. Since phosphorylation affects protein stability, for example, stability of Grb10, methods for determining a level of protein phosphorylation may also be useful in assessing protein expression levels. Some such methods for expression analysis are provided herein, and additional methods will be apparent to those of skill in the art. The invention is not limited in this respect. 
     In some embodiments, the level of expression determined for Grb10 or PTEN is compared to a reference level, for example, to a level observed or expected in a healthy cell of the same cell type or of the same tissue of origin. In some embodiments, if the level of expression of Grb10 or of PTEN in the cell is lower than the reference level, then the cell is likely to exhibit an elevated level of PI3K activity. In some embodiments, if the cell is a neoplastic cell in a subject, a method of treatment with a combination of an mTOR inhibitor and a PI3K inhibitor or with a dual mTOR/PI3K inhibitor is indicated. 
     Phosphoproteomics Binding Agents and Arrays 
     Phosphosensitive binding agents that specifically bind mTOR targets are also provided by the present invention. For example, some aspects of this invention provide antibodies and antibody fragments to each of the mTOR-targeted phosphorylation site disclosed in any of the Tables provided herein, for example, in any of Tables 1, 2, 3, 7, 8, or 11, and each such antibody is within the scope of the present invention. For example, some aspects of this invention provide aptamers and/or adnectins that specifically bind mTOR-targeted phosphorylation sites disclosed in Table 1, 2, 3, 7, 8, or 11, and each such aptamer or adnectin is within the scope of the present invention. In some embodiments, a kit is provided that comprises such phosphosensitive binding agents. A kit may also include a buffer, a container, control samples, or instructions. 
     Some embodiments provide a phosphoproteomics array that includes a plurality of phosphosensitive binding agents, for example, antibodies or antibody fragments, aptamers or adnectins, each of which specifically bind to a phosphorylation site disclosed in Table 1, 2, 3, 7, 8, or 11. In some embodiments the phosphosensitive binding agents are immobilized on a solid substrate, for example, on the surface of a glass slide, a bead, or a microtiter plate. In some embodiments, the plurality of phosphosensitive binding agents comprises binding agents that specifically bind to at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 15, at least 20, at least 25, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90, or at least 100 phosphorylation sites disclosed in Table 1. In some embodiments, the plurality of phosphosensitive binding agents comprises binding agents that specifically bind to at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 15, at least 20, at least 25, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90, or at least 100 phosphorylation sites disclosed in Table 2. In some embodiments, the plurality of phosphosensitive binding agents comprises binding agents that specifically bind to at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 15, at least 20, at least 25, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90, or at least 100 phosphorylation sites disclosed in Table 3. In some embodiments, the plurality of phosphosensitive binding agents comprises binding agents that specifically bind to at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 15, at least 20, at least 25, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90, or at least 100 phosphorylation sites disclosed in Table 7. In some embodiments, the plurality of phosphosensitive binding agents comprises binding agents that specifically bind to at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 15, at least 20, at least 25, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90, or at least 100 phosphorylation sites disclosed in Table 8. In some embodiments, the plurality of phosphosensitive binding agents comprises binding agents that specifically bind to at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 15, at least 20, at least 25, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90, or at least 100 phosphorylation sites disclosed in Table 11. 
     In some embodiments, an anti-phospho-S501/503-Grb10, anti-mTOR, anti-phospho-mTOR(S2481), anti-Grb10 (human), anti-phospho-Akt (Ser473), anti-Akt, anti-S6K, anti-phospho-S6K (T389), anti-IRS2, anti-PARP, anti-caspase 3, anti-4EBP, anti-4EBP (Ser37/46), anti-phospho-ribosomal protein S6 (Ser235/236), anti-ribosomal protein S6, anti-phospho-ERK1/2, anti-phospho-IRS (Y612), anti-p85 and anti-p110 of PI3K, and/or an anti ERK1/2 antibody or antibody fragment is provided. In some embodiments, phosphosensitive antibodies or antibody fragments are provided for mTOR upstream regulators, including, but not limited to anti-phospho-Akt (Ser473), anti-phospho-ERK1/2, anti-phospho-IRS (Y612), anti-p85, and anti-p110 of PI3K. In some embodiments, phosphosensitive antibodies or antibody fragments are provided for mTOR downstream effectors including, but not limited to anti-phospho-mTOR(S2481), anti-phospho-Akt (Ser473), anti-phospho-S6K (T389), anti-4EBP (Ser37/46), and anti-phospho-ribosomal protein S6 (Ser235/236). 
     In some embodiments, antibodies against mTORC1 downstream effectors identified for the first time herein are provided, including, anti-phospho-NDRG3 (Ser331), anti-phospho-S5011503-Grb10, and anti-CDC2-related kinase, Arg/Ser-Rich (Ser437). 
     Phosphosensitive binding agents, their generation and purification, and their use in assays, arrays, and methods for phosphoproteomics analyses of biological samples are well known in the art, and exemplary methods are described, for example, in Marjo de Graauw (Editor),  Phospho - Proteomics: Methods and Protocols  ( Methods in Molecular Biology ), Humana Press; 1 edition (2009), ISBN-10: 1603278338, incorporated herein by reference in its entirety. The foregoing reference is incorporated herein by reference in its entirety for disclosure of phosphosensitive binding agents, their generation and purification, and their use in assays, arrays, and methods for phosphoproteomics analyses of biological samples. 
     Methods of using a microarray comprising a plurality of phosphosensitive binding agents that specifically bind mTOR targets are also provided. In some embodiments, methods of using a phosphoproteomics array to determine mTOR activity in a cell, for example, in a cancer cell, are provided. In some embodiments, the method comprises contacting a proteinaceous sample derived from the cell with the phosphoproteomics array under conditions suitable for a protein expressed in the cell to bind to an antibody or antibody fragment of the array. Such conditions are well known to those of skill in the art and exemplary protocols for phosphoprotein microarrays are described in Marjo de Graauw (Editor),  Phospho - Proteomics: Methods and Protocols  ( Methods in Molecular Biology ), Humana Press; 1 edition (2009), ISBN-10: 1603278338, incorporated herein by reference for the disclosure of such methods and conditions. In some embodiments, the method further comprises determining a level of phosphorylated protein bound to a binding agent, for example, an antibody or antibody fragment of the array. In some embodiments, this step includes quantification, absolute or relative to a reference level, of the amount of protein bound to a specific binding agent. In some embodiments, the method includes comparing the level of phosphorylated protein bound to an antibody or antibody fragment of the array to a reference level, wherein if the level phosphorylated protein in the sample derived from the cell is higher than the reference level, then the cell is determined to exhibit an elevated level of mTOR kinase activity. 
     In some embodiments, methods are provided that include generating a phosphoproteomic profile of the cell. In some embodiments, the profile includes phosphorylation levels of a plurality of proteins, for example, mTOR targets expressed in the cell. In some embodiments, the method further includes comparing the phosphoproteomic profile of the cell with a phosphoproteomic profile of a control cell. In some embodiments, if the phosphoproteomic profile of the cell is similar to that of the control cell, then the cell is determined to exhibit a level of mTOR kinase activity similar to that of the control cell. Methods for comparing phosphoprotein profiles are well known in the art and include, for example, hierarchical clustering methods, supervised and unsupervised learning methods, classification methods, for example class predictor building methods based on phosphoproteomics profiles from cells of known character, and calculation of correlation parameters, such as distance analysis or correlation coefficient calculations. Useful similarity ranges are also known to those of skill in the art and the invention is not limited in this respect. For non-limiting examples of disclosures of such methods and algorithms, see Lim, Y. (2005) Mining the tumor phosphoproteome for cancer markers.  Clin Cancer Res  11(9): 3163-3169; Kalume, D. et al. (2003) Tackling the phosphoproteome: tools and strategies  Current Opinion in Chemical Biology  7: 64-69; Schmelzle, K. &amp; White, F. (2006) Phosphoproteomic approaches to elucidate cellular signaling networks.  Current Opinion in Chemical Biology  17: 406-414; Olsen J V et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.  Cell.  2006 Nov. 3; 127(3):635-48; Mumby, M. &amp; Brekken, D. (2005) Phosphoproteomics: new insights into cellular signaling. Genome Biology 6: 230.1-230.7; Zhang et al.  J. Proteome Res. vol.  5 pp. 581-8 2006; Hoffert J D, et al. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.  Proc Natl Acad Sci USA.  2006 May 2; 103(18):7159-64; Johnson, S &amp; Hunter, T. (2004) Phosphoproteomics finds its timing. Nature Biotech 22(9): 1093-1094; and Marjo de Graauw (Editor),  Phospho - Proteomics: Methods and Protocols  ( Methods in Molecular Biology ), Humana Press; 1 edition (2009), ISBN-10: 1603278338; all incorporated herein by reference in their entirety 
     In some embodiments, the control cell is a healthy cell. In some embodiments, the control cell is a cell exhibiting normal mTOR kinase activity. In some embodiments, the control cell is a cancer cell. In some embodiments, the control cell is a rapamycin-sensitive cancer cell. In some embodiments, the control cell is a rapamycin insensitive cancer cell. 
     Identification of mTOR Kinase Inhibitors Based on mTOR Target Analysis 
     In some aspects, the invention provides methods of identifying an mTOR kinase inhibitors by analyzing the phosphorylation state of an mTOR target as provided herein after contacting a cell or test sample with a candidate agent. In some embodiments, mTOR phosphorylation efficiency directed towards a target disclosed in Table 1, 2, 3, 7, 8, or 11 is measured in the presence of a candidate agent. In some embodiments, the method includes contacting an mTOR kinase molecule with a polypeptide comprising a phosphorylation site disclosed in Table 1, 2, 3, 7, 8, or 11 under conditions suitable for the mTOR kinase to phosphorylate the phosphorylation site in the presence of a candidate agent. In some embodiments, the level of phosphorylation of the phosphorylation site is then determined and compared to a reference level. In some embodiments, if the level obtained in the presence of the candidate agent is lower than the reference level, then the candidate agent is identified as an mTOR kinase inhibitor. 
     In some embodiments, the phosphorylation site is a Grb10 phosphorylation site, a pNDRG3 phosphorylation site, a CDK12 phosphorylation site, a FOXK1 phosphorylation site, a ZEB2 phosphorylation site, a LARP1 phosphorylation site, an MIB1 phosphorylation site, an IBTK phosphorylation site, and/or a SRPK2 phosphorylation site. In some embodiments, the candidate agent is a polypeptide, an aptamer, an adnectin, or a small molecule. In some embodiments, the reference level is the level of phosphorylation of the phosphorylation site determined in the absence of the candidate agent. In some embodiments, the level determined in the presence of the candidate agent is lower than the reference level, if the level determined in the presence of the candidate agent is less than 75%, less than 50%, less than 40%, less than 30%, less than 25%, less than 20%, less than 10%, less than 5%, less than 2.5%, or less than 1% of the reference level. 
     In some embodiments, the contacting is performed in vitro. In some embodiments, the contacting is performed in vivo. In some embodiments, the reference level is a level observed or expected in the absence of the candidate agent. In some embodiments, the reference level is a level observed or expected in the absence of any candidate agent. In some embodiments, the reference level is a level observed or expected in the presence of a known agent. In some embodiments, the reference level is a level observed or expected in the presence of a control agent. 
     Subjects and Cells 
     In some embodiments, the subject is an animal. In some embodiments, the subject is a domesticated animal. In some embodiments, the subject is a mammal. In some embodiments, the subject is a non-human mammal. In some embodiments, the subject is a non-human primate. In some embodiments, the subject is a mouse, rat, or rabbit. In some embodiments, the subject is a sheep, goat, cattle, pig, horse, dog, or cat. In some embodiments, the subject is a human. 
     In some embodiments, the subject is a healthy subject. In some embodiments, the subject is a subject having a hyperproliferative disease. In some embodiments, the subject is a subject having a neoplastic disease. In some embodiments, the subject is a subject having a cancer. In some embodiments, the subject is a subject having a cancer characterized and/or diagnosed to exhibit an elevated level of mTOR activity. In some embodiments, the subject is a subject who had a tumor removed. 
     In some embodiments, the cell is a healthy cell. In some embodiments, the cell is any cell. In some embodiments, the cell is a bacterial cell. In some embodiments, the cell is an animal cell. In some embodiments, the cell is a mammalian cell. In some embodiments, the cell is a human cell. In some embodiments, the cell is a cell of a cell line. In some embodiments, the cell is a transformed or immortalized cell. In some embodiments, the cell is a neoplastic cell. In some embodiments, the cell is a tumor cell. In some embodiments, the cell is a cancer cell. In some embodiments, the cell is obtained from a tumor in a subject, for example, by tumor biopsy. In some embodiments, the cell is a cell obtained from a tumor that has been removed from a subject. 
     In some embodiments, the cell is a cell known to exhibit an elevated level of mTOR activity. In some embodiments, the cell is a cell carrying a mutation in a gene involved in an mTOR signaling pathway. In some embodiments, the gene involved in an mTOR signaling pathway is a gene involved in IGF signaling, EGFR signaling, GF signaling, PI3K signaling, AKT signaling, MAPK signaling, Ras signaling, Raf signaling, or Rb signaling. In some embodiments, the gene is TSC1/2, a receptor tyrosine kinases (RTK), PI3K, PTEN, Akt, Ras, Raf, MEK, LKB, or NF2. 
     Kinase Inhibitors 
     Kinase inhibitors useful for some aspects of this invention include, but are not limited to, mTOR inhibitors, PI3K inhibitors, Akt inhibitors, and MAPK inhibitors. Further, inhibitors useful for some methods provided herein include, for example, inhibitors of mTOR target degradation, for example, inhibitors of Grb10 degradation. In some embodiments, a kinase inhibitor, for example, an mTOR inhibitor, as provided herein, is an allosteric mTOR kinase inhibitor or a catalytic mTOR kinase inhibitor. In some embodiments, the allosteric mTOR kinase inhibitor is rapamycin or a rapamycin analog. In some embodiments, the catalytic mTOR kinase inhibitor is an ATP-competitive mTOR kinase inhibitor. Other allosteric and catalytic mTOR kinase inhibitors are well known to those of skill in the art, and the invention is not limited in this respect. 
     In some embodiments, an mTOR kinase inhibitor as provided herein is an mTORC1 inhibitor. In some embodiments, an mTOR kinase inhibitor as provided herein is an mTORC1/2 inhibitor. In some embodiments, an mTOR kinase inhibitor as provided herein is rapamycin or a rapamycin analog. In some embodiments, the rapamycin analog is Ridaforolimus, Sirolimus or Everolimus. In some embodiments, an mTOR kinase inhibitor as provided herein is PP242, PP30, AZD8055, OSI-027, WYE354, INK-128, XL388, torin1, rapamycin (sirolimus), FK506 (tacrolimus), CCI779 (temsirolimus), RAD001 (everolimus), AP23573 (deforolimus, ridaforolimus), S-trans,trans-farnesyl thiosalicylic acid (FTS), FKBP38, PX-866, Theophylline, Caffeine, LY303511, PI-103, 2-(morpholin-1-yl)pyrimido[2,1-aplpha]isoquinolin-4-one, or BEZ235 (NVP-BEZ235) 
     In some embodiments, an mTOR kinase inhibitor as provided herein is a dual PI3K/mTOR kinase inhibitor. In some embodiments, the dual PI3K/mTOR kinase inhibitor is NVP-BEZ235, BGT-226, XL-765, GSK2126458 or SF1126. Some of the mTOR kinase inhibitors listed immediately above are in various stages of clinical trials. Additional mTOR inhibitors will be apparent to the skilled artisan as they are well known in the art, and it should be appreciated that the invention is not limited in this respect. 
     In some embodiments, a PI3K inhibitor is provided that is useful in a therapeutic method provided by aspects of this invention. In some embodiments, a PI3K inhibitor as provided herein is ZSTK474, TGX221, GDC0941, or LY294002, XL147, PX147, BKM120, GSK 615, CAL101, PX-866, Quercetin, Tetrodotoxin citrate, Thioperamide maleate, IC87114, PI-103, BEZ235 (NVP-BEZ235), TGX-115, (−)-Deguelin, NU 7026, Myricetin, Tandutinib, SF1126, XL765, D-87503, D-106669, or GSK615. In some embodiments, a PI3K inhibitor provided herein is a dual PI3K/mTOR kinase inhibitor, for example, NVP-BEZ235, BGT-226, XL-765, GSK2126458 or SF1126. In some embodiments, an Akt inhibitor is provided that is useful in a therapeutic method provided by aspects of this invention. In some embodiments, the Akt inhibitor is perifosine, GSK690693, A443654 or MK2206. 
     In some embodiments, a compound is provided that inhibits the degradation of an mTOR target, for example, of Grb10, NDRG3, CDK12, FOXK1, ZEB2, LARP1, MIB1, IBTK, and/or SRPK2. In some embodiments, the compound that inhibits the degradation of an mTOR target is a ubiquitin ligase inhibitor. In some embodiments, the ubiquitin ligase inhibitor is an E3 ubiquitin ligase inhibitor. 
     Compositions 
     In some embodiments, pharmaceutical compositions are provided that comprise an mTOR kinase inhibitor, a PI3K, Akt, or MAPK inhibitor, and/or an agent that inhibits the degradation of an mTOR target, for example, Grb10, NDRG3, CDK12, FOXK1, ZEB2, LARP1, MIB1, IBTK, and/or SRPK2. Pharmaceutical compositions provided herein preferably are sterile and contain an effective amount of one or more therapeutic agents as described herein for producing the desired response in a unit of weight or volume suitable for administration to a patient. If the desired response is amelioration of a hyperproliferative disease, neoplastic disease, or cancer, then the response can, for example, be measured by determining the proliferation of neoplastic or cancer cells in a subject after treatment by, for example, measuring tumor volume, evaluating regression, relapse, or disease symptoms, or by obtaining a cell sample and perform cell counting, flow cytometry, FACS, and other methods well known in the art to be suitable to determine cell proliferation. 
     In some embodiments, the pharmaceutical compositions as described herein may contain suitable buffering agents, for example, acetic acid in a salt form, citric acid in a salt form, boric acid in a salt form, and/or phosphoric acid in a salt form. The pharmaceutical compositions also may contain, optionally, suitable preservatives, such as ascorbic acid, benzalkonium chloride, benzyl alcohol, m-cresol, chlorobutanol, parabens, EDTA, EGTA, and/or thimerosal. The pharmaceutical compositions may conveniently be presented in unit dosage form and may be prepared by any of the methods well-known in the art of pharmacy. 
     In some embodiments, a therapeutic method or a method of formulating a kinase inhibitor into a medicament for therapeutic use may include the step of bringing the active agent, for example, a kinase inhibitor as described herein, into association with a carrier which constitutes one or more accessory ingredients. In general, compositions are prepared by uniformly and intimately bringing the active compound(s) into association with a liquid carrier, a finely divided solid carrier, or both, and then, if necessary, shaping the product. 
     In some therapeutic embodiments, a composition or pharmaceutic preparation provided herein is administered orally to a subject having a cancer. In some embodiments, compositions as described herein that are suitable for oral administration may be presented as discrete units, such as capsules, tablets, lozenges, each containing a predetermined amount of the active compound. Other examples of compositions include suspensions in aqueous liquids or non-aqueous liquids, such as a syrup, elixir, or an emulsion. Examples of compositions for parenteral administration include, without being limited to, sterile aqueous or non-aqueous solutions, suspensions, and emulsions. Examples of non-aqueous solvents are propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable organic esters such as ethyl oleate. Examples of aqueous carriers are water, alcoholic/aqueous solutions, emulsions or suspensions, for example, saline and buffered media. Examples of parenteral vehicles are sodium chloride solution, Ringer&#39;s dextrose, dextrose and sodium chloride, and lactated Ringer&#39;s or fixed oils. Examples for intravenous vehicles are fluid and nutrient replenishers, electrolyte replenishers (such as those based on Ringer&#39;s dextrose), and the like. Preservatives and other additives may also be present such as, for example, antimicrobials, anti-oxidants, chelating agents, and inert gases, and the like. 
     In some embodiments, a composition comprising a compound or a combination of compounds, useful in this invention, may further comprise an antioxidant to retard oxidation of one or more component. Additionally, the prevention of the action of microorganisms can be brought about by a preservative such as an antibacterial and antifungal agent, including but not limited to parabens (e.g., methylparabens, propylparabens), chlorobutanol, phenol, sorbic acid, thimerosal or combinations thereof. 
     The compounds useful in the invention, for example the mTOR, PI3K, Akt or MAPK inhibitors provided herein, may be derivatized in various ways. As used herein “derivatives” of the compounds (e.g., small molecule JAK2 and other kinase inhibitors) include salts (e.g., pharmaceutically acceptable salts), any complexes (e.g., inclusion complexes or clathrates with compounds such as cyclodextrins, or coordination complexes with metal ions such as Mn 2 + and Zn 2 +), esters such as in vivo hydrolysable esters, free acids or bases, polymorphic forms of the compounds, solvates (e.g., hydrates), prodrugs or lipids, coupling partners and protecting groups. By “prodrugs” is meant for example any compound that is converted in vivo into a biologically active compound. 
     The term “pharmaceutically acceptable salt” in this respect refers to the relatively non-toxic, inorganic or organic acid addition salts of agents of the present invention. These salts can be prepared in situ in the administration vehicle or the dosage form manufacturing process, or by separately reacting a purified agent of the invention with a suitable organic or inorganic acid, and isolating the salt thus formed during subsequent purification. Representative salts include the bromide, chloride, sulfate, bisulfate, phosphate, phosphonate, nitrate, acetate, valerate, oleate, palmitate, stearate, laurate, benzoate, lactate, tosylate, citrate, maleate, fumarate, succinate, tartrate, napthylate, mesylate, glucoheptonate, lactobionate, laurylsulphonate salts, and the like. See, for example, Berge et al. (1977) J. Pharm. Sci. 66:1-19. 
     The pharmaceutically acceptable salts of the subject agents include the conventional nontoxic salts or quaternary ammonium salts of the compounds, e.g., from non-toxic organic or inorganic acids. For example, such conventional nontoxic salts include those derived from inorganic acids such as hydrochloride, hydrobromic, sulfuric, sulfamic, phosphoric, nitric, and the like; and the salts prepared from organic acids such as acetic, propionic, succinic, glycolic, stearic, lactic, malic, tartaric, citric, ascorbic, palmitic, maleic, hydroxymaleic, phenylacetic, glutamic, benzoic, salicyclic, sulfanilic, 2-acetoxybenzoic, fumaric, toluenesulfonic, methanesulfonic, ethane disulfonic, oxalic, isothionic, and the like. 
     As set out herein, certain compounds may contain a basic functional group, such as amino or alkylamino, and are, thus, capable of forming pharmaceutically acceptable salts with pharmaceutically acceptable acids. The term “pharmaceutically acceptable salts” in this respect refers to the relatively non-toxic, inorganic or organic acid addition salts of compounds of the present invention. These salts can be prepared in situ in the administration vehicle or the dosage form manufacturing process, or by separately reacting a purified compound of the invention in its free base form with a suitable organic or inorganic acid, and isolating the salt thus formed during subsequent purification. Representative salts include the hydrobromide, hydrochloride, sulfate, bisulfate, phosphate, phosphonate, nitrate, acetate, valerate, oleate, palmitate, stearate, laurate, benzoate, lactate, tosylate, citrate, maleate, fumarate, succinate, tartrate, napthylate, mesylate, glucoheptonate, lactobionate, and laurylsulphonate salts and the like. See, for example, Berge et al. (1977)  J. Pharm. Sci.  66:1-19. 
     The pharmaceutically acceptable salts of the compounds useful in the present invention include the conventional nontoxic salts or quaternary ammonium salts of the compounds, e.g., from non-toxic organic or inorganic acids. For example, such conventional nontoxic salts include those derived from inorganic acids such as hydrochloride, hydrobromic, sulfuric, sulfamic, phosphoric, nitric, and the like; and the salts prepared from organic acids such as acetic, propionic, succinic, glycolic, stearic, lactic, malic, tartaric, citric, ascorbic, palmitic, maleic, hydroxymaleic, phenylacetic, glutamic, benzoic, salicyclic, sulfanilic, 2-acetoxybenzoic, fumaric, toluenesulfonic, methanesulfonic, ethane disulfonic, oxalic, isothionic, and the like. 
     In other cases, the compounds may contain one or more acidic functional groups and, thus, are capable of forming pharmaceutically acceptable salts with pharmaceutically acceptable bases. The term “pharmaceutically acceptable salts” in these instances refers to the relatively non-toxic, inorganic and organic base addition salts of compounds of the present invention. These salts can likewise be prepared in situ in the administration vehicle or the dosage form manufacturing process, or by separately reacting the purified compound in its free acid form with a suitable base, such as the hydroxide, carbonate or bicarbonate of a pharmaceutically acceptable metal cation, with ammonia, or with a pharmaceutically acceptable organic primary, secondary or tertiary amine. Representative alkali or alkaline earth salts include the lithium, sodium, potassium, calcium, magnesium, and aluminum salts and the like. Representative organic amines useful for the formation of base addition salts include ethylamine, diethylamine, ethylenediamine, ethanolamine, diethanolamine, piperazine, and the like. See, for example, Berge et al. (1977)  J. Pharm. Sci.  66:1-19. 
     In embodiments where the composition is in a liquid form, a carrier can be a solvent or dispersion medium comprising but not limited to, water, ethanol, polyol (e.g., glycerol, propylene glycol, liquid polyethylene glycol, etc.), lipids (e.g., triglycerides, vegetable oils, liposomes), and combinations thereof. The proper fluidity can be maintained, for example, by the use of a coating, such as lecithin; by the maintenance of the required particle size by dispersion in carriers such as, for example liquid polyol or lipids; by the use of surfactants such as, for example, hydroxypropylcellulose; or combinations thereof such methods. In many cases, it will be advisable to include isotonic agents, such as, for example, sugars, sodium chloride, or combinations thereof. 
     Therapeutic Methods 
     Some aspects of this invention provide therapeutic methods, for example, methods for the treatment of subjects having a hyperproliferative disease, a neoplastic disease, or a cancer. In some embodiments, a method of treatment is personalized to a specific subject by taking into account the phosphorylation level of at least one an mTOR target site in the subject. In some embodiments, therapeutic methods disclosed herein include administration of an mTOR inhibitor, for example, of an mTORC1 or an mTORC1/2 inhibitor. In some embodiments, therapeutic methods described herein include administration of an mTOR inhibitor and an additional kinase inhibitor, for example, a PI3K inhibitor, a MAPK inhibitor, MEKIERK inhibitor, or an AKT/PKB inhibitor. In some embodiments, therapeutic methods provided herein include administration of a dual mTOR/PI3K inhibitor, or of a combination of an mTOR inhibitor and a PI3K inhibitor. 
     In some therapeutic embodiments, a composition disclosed herein, for example, a composition comprising an mTOR inhibitor or a composition comprising an mTOR inhibitor and a PI3K inhibitor is administered to a subject having a cancer in an effective amount. An effective amount, in some embodiments, is an amount sufficient to elicit a desired clinical response in the subject. In some embodiments, the desired response is a slowing or inhibiting of the progression of a disorder, for example, of a malignant neoplastic disorder. In some embodiments, this involves slowing the progression of the disease temporarily, although, in more preferable embodiments, it involves halting the progression of the disease permanently. 
     In some embodiments, the desired response is a permanent reduction of cancer cell proliferation, for example, to a level comparable to a level found in healthy individuals. In some embodiments, a desired response is the induction of cell death in a cancer cell, in a population of cancer cells, or in all cancer cells in a subject. In some embodiments, the desired response is delaying or preventing the manifestation of clinical symptoms characteristic of the disease or condition. 
     The effect of administering an mTOR inhibitor, either alone or in combination with an additional compound, for example, a PI3K inhibitor, as provided herein, can be monitored by routine methods well known to those of skill in the related medical arts, for example, by methods involving assessment of cancer cell proliferation. 
     What constitutes an effective amount will depend on the particular condition being treated, the severity of the condition, the individual patient parameters including age, physical condition, size, and weight, the duration of the treatment, the nature of concurrent therapy (if any), the specific route of administration and like factors within the knowledge and expertise of the health care professional treating the subject. These factors are well known to those of ordinary skill in the art and can be addressed with no more than routine experimentation. It is generally preferred that a maximum dose of the individual components or combinations thereof be used, that is, the highest safe dose according to sound medical judgment. It will be understood by those of ordinary skill in the art, however, that a lower dose or tolerable dose may be used for medical reasons. 
     In general, an effective amount of a therapeutic agent, for example, an mTOR inhibitor or a combination of an mTOR inhibitor with a PI3K, Akt, or MAPK inhibitor, as provided herein, for the treatment of a cancer exhibiting an elevated level of mTOR kinase activity is a dose that achieves an alleviation of the specific neoplastic disease or disorder being treated, for example, by prevention, inhibition, amelioration, delay, or elimination of a symptom of such a disease or disorder. 
     Some embodiments provide a method of inducing cell death and/or inhibiting proliferation in a neoplastic cell exhibiting elevated mTOR kinase activity by contacting the cell with an mTOR kinase inhibitor or a combination of an mTOR kinase inhibitor and another kinase inhibitor, for example, a PI3K, Akt, or MAPK inhibitor, chosen based on the determination of the type of mTOR kinase signaling active in the cell. In some embodiments, the neoplastic cell is contacted in vivo by administering a composition disclosed herein to a subject carrying the cell. In some embodiments, the neoplastic cell is contacted ex vivo. In some embodiments, the cell is contacted in vitro. 
     In some embodiments, a neoplastic cell is contacted in vivo, ex vivo, or in vitro, with an effective amount of an mTOR inhibitor or a combination of an mTOR inhibitor and an additional kinase inhibitor, for example, a PI3K, Akt, or MAPK inhibitor, as provided herein. An effective amount, in some embodiments, is an amount sufficient to elicit a desired response in the contacted cell. In some embodiments involving contacting a neoplastic cell exhibiting elevated mTOR activity, for example, because of a mutation in an mTOR upstream pathway, the desired response is a slowing or inhibiting of the proliferation of the cell. In some embodiments, this decreases the proliferation rate and/or cell viability and/or life span, although, in more preferable embodiments, it involves the induction of cell death in the contacted cell or cells. 
     In some embodiments, the therapeutic methods provided herein further involve the administration of an additional antiproliferative agent to a cancer cell or to a subject carrying a cancer cell, for example, as part of a malignant tumor. Additional antiproliferative agents useful in the methods described herein are well known in the art and include, but are not limited to chemotherapeutic agents (e.g., cytostatic, and cytotoxic agents). Cytotoxic and cytostatic drugs are drugs that kill malignant cells, or inhibit their proliferation, respectively. Examples of cytotoxic and cytostatic drugs include, for example, alkylating agents, antimetabolites, antitumor antibiotics, vinca alkaloids, taxanes, topoisomerase-I compounds, anthrapyrazoles, and epidophylotoxins. In addition, angiogenesis inhibiting drugs, including, for example, compounds that block growth promoting receptors (e.g., PDGF-R and VEGF-R) such as sunitinib (Sutent®) may be used as additional antiproliferative agents. Non-limiting examples of additional antiproliferative agents include Cytoxan® (Cyclophosphamide), Methotrexate, 5-Fluorouracil (5-FU), Adriamycin® (Doxorubicin), Prednisone, Nolvadex® (Tamoxifen), Taxol® (Paclitaxel), Leucovorin, Oncovin® (Vincristine), Thioplex® (Thiotepa), Arimidex® (Anastrozole), Taxotere® (Docetaxel), Navelbine®, (Vinorelbine), Gemzar® (Gemcitabine), Ifex® (Ifosfamide), Pemetrexed, Topotecan, Melphalan (L-Pam®), Cisplatin (Cisplatinum®, Platinol®), Carboplatin (Paraplatin®), Carmustine (BCNU; BiCNU®), Methotrexate, Edatrexate, Mitomycin C (Mutamycin®), Mitoxantrone (Novantrone®), Vincristine (Oncovin®), Vinblastine (Velban®), Vinorelbine (Navelbine®), Fenretinide, Topotecan, Irinotecan, 9-amino-camptothecin (9-AC); Biantrazole, Losoxantrone, Etoposide, and Teniposide. 
     Administration schedules, formulations, dosages, and administration routes of antiproliferative agents and compositions are well known to those in of skill in the art. Exemplary administration routes, schedules, and dosages of commonly used chemotherapeutic drugs are described in Perry,  The Chemotherapy Source Book,  4 th  Edition, Lippinkott Williams &amp; Wilkins, 2008, incorporated herein by reference. Such administration schedules may comprise the administration of a single antiproliferative drug or the administration of a combination of such drugs, for example, one of the following, commonly administered combinations: CMF (cyclophosphamide, methotrexate, and 5-fluorouracil); classic CMF (oral cyclophosphamide plus methotrexate and 5-fluorouracil); CAF or FAC (cyclophosphamide, Adriamycin® (doxorubicin), and 5-fluorouracil); AC (Adriamycin® and cyclophosphamide); ACT (Adriamycin® plus cyclophosphamide and tamoxifen); AC taxol (Adriamycin® plus cyclophosphamide and paclitaxel (Taxol®); FACT (5-fluorouracil plus Adriamycin®, cyclophosphamide, and tamoxifen); A-CMF or Adria/CMF (4 cycles of Adriamycin® followed by 8 cycles of CMF); CMFP (CMF plus prednisone); CMFVP (CMF plus vincristine and prednisone); CAFMV (CAF plus methotrexate and vincristine); CMFVATN (CMF plus vincristine, Adriamycin®, thiotepa, and tamoxifen); MF (methotrexate plus 5-fluorouracil and leucovorin). The administration of such combinations of antiproliferative drugs and agents in addition to the administration of an mTOR kinase inhibitor with or without an additional kinase inhibitor, for example, a PI3K, Akt, or MAPK inhibitor, is also envisioned to be embraced by some embodiments. 
     The therapeutic inhibitors and compositions can be administered in a single dose comprising an effective amount of the individual agents. Multiple doses of the compounds of the invention are also contemplated. When a plurality of inhibitors are used together, they may be administered individually or sequentially, either in a single medicament or in separate units to provide therapeutic doses of the individual compounds. Many mTOR inhibitors, PI3K inhibitors, Akt inhibitors and MAPK inhibitors described herein are in clinical studies or even in clinical use. Therapeutic doses of such compounds are, accordingly, well known in the field of medicine. Dosages of compounds in clinical use are described in references such as  Remington&#39;s Pharmaceutical Sciences,  18th ed., 1990; as well as many other medical references relied upon by the medical profession as guidance for the treatment of proliferation disorders. 
     Administration Routes and Methods 
     A variety of administration routes are available for the kinase inhibitors and other therapeutic agents described herein. The particular mode selected will depend, of course, upon the particular compound selected, the particular condition being treated and the dosage required for therapeutic efficacy. The methods of this invention may be practiced using any mode of administration that is medically acceptable, meaning any mode that produces effective levels of compounds without causing clinically unacceptable adverse effects. Examples of modes of administration are parenteral routes. The term “parenteral” includes subcutaneous, intravenous, intramuscular, intraperitoneal, and intrasternal injection, or infusion techniques. Other routes include, but are not limited to, oral, nasal, dermal, sublingual, and local. 
     The formulations of the invention are administered in pharmaceutically acceptable solutions, which may routinely contain pharmaceutically acceptable concentrations of salts, buffering agents, preservatives, compatible carriers, adjuvants, and optionally other therapeutic ingredients. 
     According to the methods provided by aspects of the invention, the compounds described herein may be administered in a pharmaceutical composition. In some embodiments, a pharmaceutical composition comprises a compound provided by aspects of the invention and a pharmaceutically acceptable carrier. As used herein, a pharmaceutically acceptable carrier refers to a non-toxic material that does not interfere with the effectiveness of the biological activity of the active ingredients. 
     Pharmaceutically acceptable carriers include diluents, fillers, salts, buffers, stabilizers, solubilizers, and other materials which are well known in the art. Such preparations may routinely contain salt, buffering agents, preservatives, compatible carriers, and optionally other therapeutic agents. When used in medicine, the salts should be pharmaceutically acceptable, but non-pharmaceutically acceptable salts may conveniently be used to prepare pharmaceutically acceptable salts thereof and are not excluded from the scope of the invention. Such pharmacologically and pharmaceutically acceptable salts include, but are not limited to, those prepared from the following acids: hydrochloric, hydrobromic, sulfuric, nitric, phosphoric, maleic, acetic, salicylic, citric, formic, malonic, succinic, and the like. Also, pharmaceutically acceptable salts can be prepared as alkaline metal or alkaline earth salts, such as sodium, potassium or calcium salts. 
     The compounds used in the invention may be formulated into preparations in solid, semi-solid, liquid or gaseous forms such as tablets, capsules, powders, granules, ointments, solutions, depositories, inhalants and injections, and usual ways for oral, parenteral or surgical administration. Some aspects of the invention also embrace pharmaceutical compositions which are formulated for local administration, such as by implants. 
     Compositions suitable for oral administration may be presented as discrete units, such as capsules, tablets, lozenges, each containing a predetermined amount of the active compound. Other compositions include suspensions in aqueous liquids or non-aqueous liquids such as a syrup, elixir or an emulsion. When the compounds described herein are used therapeutically, in certain embodiments a desirable route of administration may be by pulmonary aerosol. 
     In some embodiments, a compound provided by some aspects of the invention may be administered directly to a tissue. Direct tissue administration may be achieved by direct injection. A compound may be administered once or alternatively may be administered in a plurality of administrations. If administered multiple times, a compound may be administered via different routes. For example, the first (or the first few) administrations may be made directly into the affected tissue while later administrations may be systemic. 
     For oral administration, the compounds can be formulated readily by combining the active compounds with pharmaceutically acceptable carriers well known in the art. Such carriers enable the compounds of the invention to be formulated as tablets, pills, dragees, capsules, liquids, gels, syrups, slurries, suspensions and the like, for oral ingestion by a subject to be treated. Pharmaceutical preparations for oral use can be obtained as solid excipient, optionally grinding a resulting mixture, and processing the mixture of granules, after adding suitable auxiliaries, if desired, to obtain tablets or dragee cores. Suitable excipients are, in particular, fillers such as sugars, including lactose, sucrose, mannitol, or sorbitol; cellulose preparations such as, for example, maize starch, wheat starch, rice starch, potato starch, gelatin, gum tragacanth, methyl cellulose, hydroxypropylmethyl-cellulose, sodium carboxymethylcellulose, and/or polyvinylpyrrolidone (PVP). If desired, disintegrating agents may be added, such as the cross-linked polyvinyl pyrrolidone, agar, or alginic acid or a salt thereof such as sodium alginate. Optionally the oral formulations may also be formulated in saline or buffers for neutralizing internal acid conditions or may be administered without any carriers. 
     Dragee cores are provided with suitable coatings. For this purpose, concentrated sugar solutions may be used, which may optionally contain gum arabic, talc, polyvinyl pyrrolidone, carbopol gel, polyethylene glycol, and/or titanium dioxide, lacquer solutions, and suitable organic solvents or solvent mixtures. Dyestuffs or pigments may be added to the tablets or dragee coatings for identification or to characterize different combinations of active compound doses. 
     Pharmaceutical preparations which can be used orally include push-fit capsules made of gelatin, as well as soft, sealed capsules made of gelatin and a plasticizer, such as glycerol or sorbitol. The push-fit capsules can contain the active ingredients in admixture with filler such as lactose, binders such as starches, and/or lubricants such as talc or magnesium stearate and, optionally, stabilizers. In soft capsules, the active compounds may be dissolved or suspended in suitable liquids, such as fatty oils, liquid paraffin, or liquid polyethylene glycols. In addition, stabilizers may be added. Microspheres formulated for oral administration may also be used. Such microspheres have been well defined in the art. All formulations for oral administration should be in dosages suitable for such administration. 
     For buccal administration, the compositions may take the form of tablets or lozenges formulated in conventional manner. 
     For administration by inhalation, the compounds for use according to the present invention may be conveniently delivered in the form of an aerosol spray presentation from pressurized packs or a nebulizer, with the use of a suitable propellant, e.g., dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas. In the case of a pressurized aerosol the dosage unit may be determined by providing a valve to deliver a metered amount. Capsules and cartridges of, e.g., gelatin for use in an inhaler or insufflator may be formulated containing a powder mix of the compound and a suitable powder base such as lactose or starch. 
     The compounds, when it is desirable to deliver them systemically, may be formulated for parenteral administration by injection, e.g., by bolus injection or continuous infusion. Formulations for injection may be presented in unit dosage form, e.g., in ampoules or in multi-dose containers, with an added preservative. The compositions may take such forms as suspensions, solutions, or emulsions in oily or aqueous vehicles, and may contain formulatory agents such as suspending, stabilizing, and/or dispersing agents. 
     Preparations for parenteral administration include sterile aqueous or non-aqueous solutions, suspensions, and emulsions. Examples of non-aqueous solvents are propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable organic esters such as ethyl oleate. Aqueous carriers include water, alcoholic/aqueous solutions, emulsions or suspensions, including saline and buffered media. Parenteral vehicles include sodium chloride solution, Ringer&#39;s dextrose, dextrose and sodium chloride, lactated Ringer&#39;s, or fixed oils. Intravenous vehicles include fluid and nutrient replenishers, electrolyte replenishers (such as those based on Ringer&#39;s dextrose), and the like. Preservatives and other additives may also be present such as, for example, antimicrobials, anti-oxidants, chelating agents, and inert gases and the like. Lower doses will result from other forms of administration, such as intravenous administration. In the event that a response in a subject is insufficient at the initial doses applied, higher doses (or effectively higher doses by a different, more localized delivery route) may be employed to the extent that patient tolerance permits. Multiple doses per day are contemplated to achieve appropriate systemic levels of compounds. 
     Other delivery systems can include time-release, delayed release or sustained release delivery systems. Such systems can avoid repeated administrations of the compound, increasing convenience to the subject and the physician. Many types of release delivery systems are available and known to those of ordinary skill in the art. They include polymer base systems such as poly(lactide-glycolide), copolyoxalates, polycaprolactones, polyesteramides, polyorthoesters, polyhydroxybutyric acid, and polyanhydrides. Microcapsules of the foregoing polymers containing drugs are described in, for example, U.S. Pat. No. 5,075,109. Delivery systems also include non-polymer systems that are: lipids including sterols such as cholesterol, cholesterol esters and fatty acids or neutral fats such as mono- di- and tri-glycerides; hydrogel release systems; silastic systems; peptide based systems; wax coatings; compressed tablets using conventional binders and excipients; partially fused implants; and the like. Specific examples include, but are not limited to: (a) erosional systems in which the platelet reducing agent is contained in a form within a matrix such as those described in U.S. Pat. Nos. 4,452,775, 4,675,189, and 5,736,152 and (b) diffusional systems in which an active component permeates at a controlled rate from a polymer such as described in U.S. Pat. Nos. 3,854,480, 5,133,974 and 5,407,686. In addition, pump-based hardware delivery systems can be used, some of which are adapted for implantation. 
     Therapeutic formulations useful in the invention may be prepared for storage by mixing a kinase inhibitor having the desired degree of purity with optional pharmaceutically acceptable carriers, excipients or stabilizers ( Remington&#39;s Pharmaceutical Sciences  16th edition, Osol, A. Ed. (1980)), in the form of lyophilized formulations or aqueous solutions. Acceptable carriers, excipients, or stabilizers are nontoxic to recipients at the dosages and concentrations employed, and include buffers such as phosphate, citrate, and other organic acids; antioxidants including ascorbic acid and methionine; preservatives (such as octadecyldimethylbenzyl ammonium chloride; hexamethonium chloride; benzalkonium chloride, benzethonium chloride; phenol, butyl or benzyl alcohol; alkyl parabens such as methyl or propyl paraben; catechol; resorcinol; cyclohexanol; 3-pentanol; and m-cresol); low molecular weight (less than about 10 residues) polypeptides; proteins, such as serum albumin, gelatin, or immunoglobulins; hydrophilic polymers such as polyvinylpyrrolidone; amino acids such as glycine, glutamine, asparagine, histidine, arginine, or lysine; monosaccharides, disaccharides, and other carbohydrates including glucose, mannose, or dextrins; chelating agents such as EDTA; sugars such as sucrose, mannitol, trehalose or sorbitol; salt-forming counter-ions such as sodium; metal complexes (e.g., Zn-protein complexes); and/or non-ionic surfactants such as TWEEN™, PLURONICS™ or polyethylene glycol (PEG). 
     EXAMPLES 
     Two sets of large-scale, quantitative phospho-proteomics experiments were performed to fully define how mTOR-containing complexes signal to downstream effectors ( FIG. 1A ). The first SILAC experiment (rapamycin screen) was performed using growth factor-deprived TSC2−/− mouse embryonic fibroblasts (MEFs). Deletion of the TSC2 tumor suppressor gene decouples mTORC1 from many upstream inputs, leading to constitutive hyper-activation of mTORC1 signaling (7). mTORC1 is still potently and specifically inhibited by rapamycin in these cells, which provides a sensitized genetic background for the study of mTORC1 signaling in the absence of other mitogen-regulated phosphorylation cascades. 
     Global Quantitative Phosphoproteomics Defines the Signaling Networks Downstream of both mTORC1 and mTORC2 
     Two populations of TSC2−/− cells were grown in parallel, one in conventional media (“light”) and the other in media containing [ 13 C 6   15 N 2 ]lysine and [ 13 C 6   15 N 4 ]arginine (“heavy”) ( FIG. 1A  and Table 5). As shown in  FIG. 5A , phosphopeptides were successfully enriched using a two-step SCX-IMAC procedure with the phosphopeptides representing 67.8% of the peptides identified. We performed two biological replicates of this experimental design with cross-labeling (swapping the labeled state of the rapamycin-treated cells, Table 5), from which a total of 14,635 (FDR=0.25%) and 32,500 (FDR=0.28%) phosphopeptides were identified, respectively. These corresponded to identification of at least 4,484 and 6,832 unique phosphorylation sites on 1,615 and 1,866 proteins, respectively. The quantitation was highly accurate (Table 5) with 93.7% of the phosphoproteome changing less than 50% in abundance between the rapamycin-treated (light) and control (heavy) cells (second biological replicate experiment, Median Log 2 (H/L)=−0.02 and standard deviation Log 2 (H/L)=0.53,  FIG. 1A ). Gene names and sequences of the phosphopeptides whose intensities decrease after rapamycin treatment (Rapamycin screen) are identified in Table 7. Note that the Rapamycin screen includes two biological replicates. For the first replicate (Table 7 Rapa Replicate 1), the light cells were controls whereas the heavy cells were treated with rapamycin. For the second replicate experiment (Table 7 Rapa Replicate 2), the light cells were treated with rapamycin and heavy cells were controls. 
     Based on the tight distribution of the quantified phosphopeptides, we considered phosphorylated peptides whose relative abundance decreased ≧2-fold as regulated in a rapamycin-sensitive fashion. Using this criteria, several hundred peptides (corresponding to 148 and 85 proteins respectively, in the two biological replicates, Table 11) were determined to contain rapamycin-sensitive phosphorylation sites. Table 11 identifies proteins with downregulated phosphorylation identified in the rapamycin and Ku-0063794 screen. Note that there are two biological replicate experiments for the rapamycin screen (“Table 11 Rapa Replicate 1,” and “Table 11 Rapa Replicate 2,” respectively) and one Ku-0063749 replicate (“Table 11 Ku”). Treatment for the light and heavy cells in each experiment is described in  FIG. 1C . We observed a similar distribution for the phosphopeptides in the first biological replicate experiment and found 85 proteins (Table 11) that carried rapamycin-sensitive phosphorylation sites. In addition, there was a substantial overlap in the down-regulated proteins between replicates and 40 of these proteins were found in both experiments ( FIG. 5B ). 
     For the Ku-screen, wild-type MEFs were grown in light and heavy SILAC media and starved overnight for serum. The light cells were treated with 20 nM rapamycin for 2 hrs, while the heavy cells were treated in parallel with a combination of 20 nM rapamycin and 2 μM of Ku-0063794 for 2 hrs. Both the light and heavy cell were subsequently stimulated with insulin for 15 minutes and samples were pooled and analyzed by quantitative mass spectrometry. Ku-0063794 is a recently identified compound that competitively inhibits mTOR kinase activity by occupying the ATP-binding pocket ( FIG. 5C ) (4, 11). For the Ku-screen, a total of 34,642 phosphopeptides were identified with a false discovery rate of 0.28%, which corresponded to identification of 6,220 unique phosphorylation sites on 1,867 proteins (Table 5). Gene names and sequences of the phosphopeptides whose intensities decrease after Ku-0063794 treatment are identified in Table 8. Note that the light cells were treated with rapamycin and serve as controls whereas the heavy cells were treated with a combination of rapamycin and Ku-0063794. A very tight distribution of phosphopeptides was observed (Median Log 2 (H/L)=−0.03 and standard deviation Log 2 (H/L)=0.34) and phosphorylated peptides whose relative abundance decreased ≧2-fold were considered regulated by Ku-sensitive, but rapamycin-insensitive mTOR signaling ( FIG. 1A ). Using these criteria, 100 proteins were determined to contain downregulated phosphorylation after Ku-0063794 treatment (Table 11). The identified phopho-proteins included many known downstream targets of mTORC2 (Table 6), including GSK3β, Braf, Akt1s1 (Akt substrate) and NDRG1 (SGK substrate). Combining the data from both the Rapa-screen and the Ku-screen, we identified a total of 81,777 phosphopeptides, and more than 11,271 unique phosphorylations sites on 2,778 proteins, with 9,694 of the sites confidently localized (A score ≧13) (Table 5). 
     Phosphorylation Specificity of the Downstream Effectors in the mTORC1 and mTORC2 Signaling Networks 
     Table 9 describes the classification of mTOR targets identified in the rapamycin and Ku-0063794 screens. Class I includes downstream effectors of rapamycin-sensitive mTORC1. Class II includes downstream effectors of rapamycin-insensitive mTORC1 or mTORC2. Class II includes the proteins downstream of both mTORC1 and mTORC2. Names of the genes and the sequences of the phosphopeptides are shown. 
     Class I sites represent phosphorylation events that are mediated by rapamycin-sensitive mTORC1/S6K signaling, (e.g. phospho-rpS6 S235/S236 phosphorylation). 
     Class II sites represent phosphorylation events mediated by rapamycin-insensitive mTORC1 or mTORC2 function. For example, 4EBP1 T36/T45 phosphorylation, previously characterized as a rapamycin insensitive mTORC1 substrate (12), only decreased slightly (20%) after rapamycin treatment, while phosphorylation at these sites decreased dramatically (7.2-fold) in the Ku-0063794 screen ( FIGS. 1C ,  5 C and  6 A). As another example, NDRG1 was also identified to contain Class II phosphorylation sites at S330/S333 ( FIGS. 1C and 6B ) and was recently shown to be a substrate of SGK (8), whose activation is under the control of mTORC2. 
     Class III represents phosphorylation sites that are both the rapamycin-sensitive and Ku-sensitive mTOR substrates. For example, GSK3β S9 phosphorylation is down-regulated by approximately 3.3-fold and 2.2-fold in the rapamycin and Ku-0063794 screens, respectively ( FIGS. 1C and 6C ), consistent with the previous observation that it can be a substrate of both Akt and S6K (9). As another example for the Class III phosphorylation, the abundance of mTOR autophosphorylation at S2478/S2481 decreased 3.6-fold in the rapamycin screen ( FIG. 7A ). Surprisingly, it was previously shown that S2481 is a conserved, rapamycin-insensitive, autophosphorylation site of mTOR ( FIG. 7B ) (20). Immunoblot analysis confirmed that site was indeed rapamycin-sensitive ( FIGS. 5C and 7C ). Intriguingly, acute rapamycin treatment only led to partial dephosphorylation of this site. In contrast, mTOR S2481 phosphorylation was completely abolished as a result of mTOR kinase inhibitor treatment ( FIGS. 5C and 7D ). Taken together, the data demonstrate that mTOR S2481 phosphorylation is regulated in both a rapamycin sensitive- and insensitive-manner. 
     There were several surprising examples of phosphopeptides that are insensitive to both rapamycin and Ku-0063794 as identified by the two phosphoproteomics screens. The intensity of a T70 singly phosphorylated 4EBP 1 peptide did not change in either the rapamycin or the Ku-0063794 screen ( FIGS. 1C and 6A ), indicating the 4EBP T70 is not phosphorylated by mTOR in this context. Indeed, several reports suggested that this site might be targeted by ERK2, another proline-directed kinase (21). In addition, we found that the 4EBP-1 S85/S 100 phosphorylation was also mTOR-independent ( FIG. 1C ). 
     Linking Phosphorylation Events to the Biological Processes Regulated by mTORC1 and mTORC2 
     To assess the predicated effects of mTOR inhibition in cells as a result of either rapamycin or Ku-0063794 treatment, we mapped the downregulated proteins in the two screens to Gene Ontology (GO) terms with respect to Biological Process (BP) and also performed gene functional classification analysis of these proteins. Table 10 describes the results of GO analysis of the hits identified in the rapamycin and Ku-0063794 screens. Pathways that the rapamycin-sensitive and Ku-0063794-sensitive hits overrepresented are shown in “Table 10 Rapa pathways” and “Table 10 Ku pathways”, respectively. Also shown is the biological process that the rapamycin-sensitive and Ku-0063794-sensitive hits overrepresented (Table 10 Rapa BP GO, and Table 10 Ku BP GO, respectively). Interestingly, for the rapamycin screen, the top enriched BPs included negative regulation of macromolecule metabolic process (P=4.2×10 −7 ), negative regulation of cellular biosynthetic process (P=4.2×10 −6 ), response to insulin stimulus (P=2.6×10 −4 ), negative regulation of transcription (P=2.7×10 −4 ) and vesicle-mediated transport (P=6.0×10 −4 ). By grouping the hits based on functional similarities, we also found that the downregulated proteins in the rapamycin screen were enriched for kinases (P=2.1×10 −20 ), WD40-repeat containing proteins (P=8.9×10 −12 ), proteins involved in transcription regulation (P=3.1×10 −9 ) and proteins involved in RNA processing (P=3.3×10 −5 ). The identification of many kinases in the downregulated proteins provides interesting points for potential signal integration and crosstalk. One example is the Ser/Thr kinase, unc-51-like kinase 1 (ULK1). Previously published research has demonstrated that ULK1 is positively involved in autophagy response (22). ULK1 has also been shown to interact with mTORC1 through binding to raptor (23). We identified three phosphorylation sites on ULK1 (S747/S757/T763) that showed a 4-fold downregulation after rapamycin treatment (Table 1), suggesting that ULK1 is likely a bona fide mTORC1 substrate. As mTORC1 is known to antagonize macroautophagy, it is tempting to speculate that mTORC1 negative regulates ULK1 either directly or indirectly via inhibitory phosphorylation events. Interestingly, in mammalian cells, knockdown of the related kinase ULK2 had no effect on the autophagic response (22). Interestingly, all three of the rapamycin-sensitive ULK1 phosphorylation sites are proline-directed (SP or TP), whereas two of the three comparable sites in ULK2 possess a C-terminal alanine, making it unlikely that these residues are similarly phosphorylated by mTORC1 ( FIG. 7E ). 
     For the downregulated proteins identified in the Ku-0063794 screen, the top enriched BPs included lamellipodium assembly (P=0.003), protein amino acid phosphorylation (P=0.007), the insulin receptor signaling pathway (P=0.01), actin filament-based process (P=0.015) and nucleocytoplasmic transport (P=0.015). Gene functional classification analysis revealed that the downregulated proteins were enriched for ATP-binding proteins (P=2.4×10 −11 ) and zinc-finger domain containing proteins (P=2.1×10 −4 ). Intriguingly, it has been suggested that mTORC2 promotes organization of the actin cytoskeleton upon growth factor stimulation through a mechanism that is poorly defined. The identification of a total of 10 proteins (CCDC88A, ARHGEF17, NCK1, myo9b, Mtap1b, Epb4.113, vel, Spnb2, FLNC, Npm1) in the Ku-0063794 screen that are related to cytoskeleton regulation provides an opportunity for the discovery of novel points of regulation. For example, we identified a peptide from filamin-C (FLNC) in the Ku-0063794 screen that was singly phosphorylated at S2234 ( FIG. 2 ). S2234 is localized in an AGC kinase substrate motif (RERLGS*F, SEQ ID NO: 22) and has previously been shown to be phosphorylated by Akt in vitro (24). We found S2234 could be categorized as a Class II phosphorylation site (rapamycin-insensitive and Ku0063794-sensitive,  FIG. 2  and Table 1), suggesting that it is not an S6K substrate but rather the substrate of Akt or SGK. FLNC crosslinks actin filaments into a three-dimensional network and is involved in assembling signaling complexes near the cell membrane (25). Interestingly, filamin-A (FLNA) has been shown to be phosphorylated at a similar site (S2152, RRRAPS*V, SEQ ID NO: 23) by RSK and Pak protein kinases which regulates FLNA function in cell migration (26). It will clearly be of great interest to investigate whether mTORC2 regulates actin assembly and cell migration through Akt- or SGK-mediated phosphorylation of FLNC and whether this phosphorylation coordinates regulation of these processes with Ras-, Cdc42- and Rac-mediated phosphorylation of FLNA. 
     The analysis identified 4,484 and 6,832 unique phosphorylation sites on 1,615 and 1,866 proteins from two biological replicate experiments, respectively, and achieved a high level of accuracy in quantitation (Table 5). Several hundred peptides corresponding to 148 and 85 proteins in the two replicates (Table 11) were determined to contain rapamycin-sensitive phosphorylation sites (defined as phosphorylated peptides whose relative abundance decreased ≧2-fold in response to rapamycin treatment). There was a substantial overlap in the downregulated proteins between the replicates, as 40 proteins were found in both experiments ( FIG. 5B ). Supporting the validity of the approach, many known effectors of the mTORC1 signaling pathway were identified in the downregulated population (Table 6), including p70S6K, 4EBP1/2, Akt1s1 (PRAS40), rpS6, eIF4B, eIF4G1 and GSK3β. A representative identification of the known rapamycin-sensitive phosphorylation sites on ribosomal protein S6 is shown in  FIG. 1B . 
     Rapamycin is an allosteric inhibitor that only partially inhibits mTORC1 signaling and has no effect on the activity of mTORC2 under short-term treatment conditions (3). In contrast, newly discovered ATP-competitive mTOR inhibitors block the activity of both mTORC1 and mTORC2 (2). To identify rapamycin-insensitive mTORC1, and mTORC2 substrates, we used the mTOR kinase inhibitor Ku-0063794 and performed a second SILAC experiment (Ku-0063794 screen) ( FIG. 1A ). The light cells were treated with 20 nM rapamycin for 2 hrs, while the heavy cells were treated in parallel with a combination of 20 nM rapamycin and 2 μM of Ku-0063794 for 2 hrs. Both the light and heavy cells were subsequently stimulated with insulin for 15 minutes and samples were pooled and analyzed by quantitative mass spectrometry. By creating a rapamycin-inhibited background in both the light and heavy cells, the combination of insulin stimulation and treatment with the mTOR kinase inhibitor leads to the identification of proteins specficially phosphorylated by rapamycin-insensitive mTOR signaling and kinases activated downstream of mTORC2 such as Akt and SGK. 
     In this experiment, one hundred proteins were determined to contain down-regulated phosphorylation after Ku-0063794 treatment (Table 11). The identified phospho-proteins included many known downstream targets of mTORC2 (Table 6), including GSK313, Braf, Akt1s1 (Akt substrates) and NDRG1 (SGK substrate). 
     To identify the specific downstream effectors of the two mTOR complexes, we compared the fold-change in phospho-peptides identified in both the rapamycin and Ku-0063794 screens ( FIG. 1C ). As expected, the majority of phospho-peptides in the cell are not affected by either rapamycin or Ku-0063794 treatment and show a heavy:light ratio close to 1:1 in both screens. However, there are clearly phosphopeptides that are mediated by mTORC1 and/or mTORC2 signaling, which can further be divided into three categories. Class I sites include rapamycin-sensitive events that are not further decreased by Ku-0063794 treatment, and represent canonical mTORC1 downstream effectors, such as rpS6 S235/236 phosphorylation ( FIG. 1C ). Class II sites include Ku-0063794-sensitive events that are not affected by rapamycin treatment and represent either rapamycin-resistant mTORC1 downstream effectors, such as 4EBP1 T36/T45 ( FIGS. 1C ,  5 C and  6 A), or sites downstream of the mTORC2 signaling, such as the recently described SGK-mediated NDRG1 S330/S333 phosphorylation events ( FIGS. 1C and 6B ) (8). Finally, Class III sites are sensitive to both compounds. For example, GSK3β S9 phosphorylation is downregulated in both the rapamycin and Ku-0063794 screens ( FIGS. 1C and 6C ), consistent with the previous observation that GSK313 can be a substrate of both Akt and S6K (9). In addition, we identified mTOR autophosphorylation at S2481 as a Class III site that is regulated in both a rapamycin sensitive- and insensitive-manner ( FIG. 7 ) (these target classes are discussed in more detail elsewhere herein). 
     We performed pathway analysis using DAVID (10), to determine the signaling networks that are statistically overrepresented by the hits in the rapamycin and Ku-0063794 screens ( FIGS. 1D and 5D ). Not surprisingly, proteins with downregulated phosphorylation in both screens were highly enriched for the canonical mTOR pathway (P=1.6×10 −6 , ranked first, for the rapamycin screen and P=0.0014, ranked second, for the Ku-0063794 screen). 
     Interestingly, one of the enriched GO classes in the rapamycin screen is the transmembrane receptor protein tyrosine kinase (RTK) signaling pathway (P=0.01), suggesting that mTORC1 might inhibit proteins in the upstream PI3K and MAPK pathways through modulating the activities of these RTKs. In particular, we observed that phosphorylation of two sites on the growth factor receptor-bound protein 10 (Grb10, S501/S503,  496 MNILSS*QS*PLHPSTLNAVIHR 516  (SEQ ID NO: 24), mass error=2.32 ppm, Xcorr=4.39) was strongly inhibited by rapamycin ( FIGS. 2A and 8A ). The level of phosphorylation decreased by more than 27-fold after a 2 h rapamycin treatment (Table 6). The intensity of a triply phosphorylated Grb10 peptide (T76/S96/S104, insufficient MS/MS fragment ions to localize T76) also decreased by about five-fold after rapamycin treatment (Table 6). In contrast, phosphorylation of two other Grb10 sites, 5455 and 5458, did not change after a 2-hr rapamycin treatment ( FIG. 8B ), suggesting that decreased S501/S503 phosphorylation was not the result of a change in Grb10 protein abundance. 
     Grb10 belongs to the growth factor receptor-bound (Grb) protein family, which contains Grb7, Grb10 and Grb14. Members of this protein family serve as cellular adaptor proteins that bind to activated receptor tyrosine kinases (11). Grb10 has an N-terminal Ras-associating (RA) domain, a PH domain, a C-terminal SH2 domain and a BPS (between PH and SH2) domain, in which the two rapamycin-sensitive phosphorylation sites reside ( FIG. 2B ). The S501/S503 sites, and their flanking sequences, are highly conserved in vertebrates ( FIG. 2B ), suggesting that they could be functionally relevant and phosphorylated by a common evolutionarily conserved kinase, such as mTOR. 
     We developed a phosphospecific antibody ( FIGS. 9A and 9B ) to further characterize these two Grb10 phosphorylation sites. Treatment of TSC2−/− MEFs with 20 nM rapamycin induced rapid dephosphorylation of Grb10, within 15 min, and remained completely inhibited for the remainder of the time course examined ( FIG. 2C ). The dephosphorylation kinetics correlated well with that of S6K. We also found that Grb10 phosphorylation at S501/S503 is sensitive to amino acid availability in TSC2−/− MEFs ( FIG. 2D ). 
     To determine whether the Grb10 S501/S503 sites can be phosphorylated by other kinases, we treated TSC2−/− cells with staurosporine, a broad-spectrum kinase inhibitor that does not suppress mTOR activity (12). No change in the phosphorylation level of Grb10 S501/S503 phosphorylation was observed in response to staurosporine treatment ( FIG. 2E ). In contrast, treatment of Ku-0063794 led to a dose-dependent dephosphorylation of Grb10, correlating with the dephosphorylation of mTOR, 4EBP and rpS6. Interestingly, S6K activity was inhibited by staurosporine treatment, as shown by a complete loss of rpS6 phosphorylation, suggesting that Grb10 S501/S503 was directly phosphorylated by mTORC1 rather than by S6K. 
     We further investigated the effects of growth factor stimulation and rapamycin-mediated inhibition on Grb10 phosphorylation in other cell types. Wild-type MEFs were serum-starved and then stimulated with either insulin or 10% serum, both of which led to a robust increase in Grb10 phosphorylation ( FIG. 2F ). The insulin- or serum-induced increase in Grb10 phosphorylation was completely blocked by rapamycin pre-treatment. It was previously reported that Grb10 S503 (S476 in human Grb10 isoform 3) was phosphorylated by ERK1/2 in vitro (13). We found that inhibiting MEK by using AZD6244 completely abolished the activities of ERK but had no effect on Grb10 S501/S503 phosphorylation ( FIG. 2F ), indicating that phosphorylation at these two sites on Grb10 is not mediated by ERK in vivo. We also tested other mTOR catalytic site inhibitors, including LY294002, NVP-BEZ235, torin and pp 242 (14), all of which completely abolished Grb10 S501/S503 phosphorylation ( FIG. 2G ). 
     We next examined the in vivo interaction between Grb10 and the components of the mTOR complexes. We co-overexpressed HA-tagged Grb10 with Myc-tagged raptor or rictor in HEK293T cells. Grb10 was found to interact with raptor, but not rictor, suggesting Grb10 is a binding partner of mTORC1, but not mTORC2 ( FIG. 3A ). To further evaluate the possibility that Grb10 is a substrate of mTORC1, we prepared recombinant Grb10 from bacteria and subjected it to an in vitro kinase assay using recombinant mTOR. As shown in  FIG. 3B , Grb10 was robustly phosphorylated by recombinant mTOR at S501/S503. 
     We found long-term inhibition of mTORC1 by rapamycin led to a significant decrease in Grb10 protein levels ( FIG. 3C ) while Grb10 mRNA levels showed a modest (approximately 2-fold) decrease, suggesting mTORC1 activity positively regulates Grb10 expression at both the transcriptional and post-translational levels. Similarly, knockdown of the mTORC1 component raptor led to a decreased level of Grb10 protein, correlating with diminished mTORC1 activity, as shown by phospho-4EBP levels ( FIG. 3D ). In addition, long-term treatment with mTOR kinase inhibitors, including LY-294002, NVP-BEZ235, torin and pp 242 all led to reduced Grb10 protein expression ( FIG. 9C ). Similar results were obtained in TSC1−/− MEFs ( FIG. 9D ). In contrast, we found Grb10 was highly overexpressed in TSC2−/− and TSC1−/− MEFs compared with their wild-type counterparts ( FIGS. 3E and 9E ), correlating with elevated mTORC1 activity in these cells. 
     To explore whether mTORC1-mediated Grb10 stabilization depends on phosphorylation on S501/S503, we transfected WT-Grb10, Grb10-S501A/S503A (AA) mutant and Grb10-S501D/S503D (DD) mutant into HEK293T cells. Exogenous wild type (WT) and DD mutant Grb10 proteins were expressed at equal levels, while expression of the AA mutant was markedly reduced, suggesting lower protein stability for the unphosphoryated form of Grb10 ( FIG. 3F ). To confirm this result, we generated TSC2−/− MEFs stably expressing the HA-tagged Grb10-DD mutant and treated these cells with rapamycin. Long-term rapamycin treatment decreased endogenous, wild-type Grb10 levels but had no effect on the DD mutant protein levels ( FIG. 3G ). To rule out the possibility that this result was an artifact based on protein overexpression, we repeated the experiment on TSC2−/− cells expressing HA-tagged wild-type Grb10, in which rapamycin treatment decreased both the endogenous and ectopically expressed Grb10 ( FIG. 9F ). These data support a critical role for mTORC1 in stabilizing Grb10 through phosphorylation of the S5011S503 residues. 
     Grb10 has been suggested to function as a negative regulator of the insulin signaling pathway. In mice with genetically disrupted Grb10 function, overgrowth of both the embryo and placenta was observed, and these mice are approximately 30% larger than normal at birth (15). In addition, enhanced activity of the insulin-stimulated PI3K/Akt pathway was observed in insulin target tissues, including skeletal muscle and adipose tissue (16). We examined the role of mTORC1-mediated Grb10 protein stabilization and accumulation in mTORC1 mediated negative feedback on the PI3K/Akt pathway. 
     As expected from previous reports (5, 6), both the PI3K/Akt and MAPK pathways were highly suppressed in TSC2−/− cells due to constitutively elevated mTORC1 activity. In contrast, Akt was strongly activated in Grb10 knockdown cells under both serum-starved and insulin/IGF stimulation conditions ( FIG. 4A ). In addition, Grb10 knockdown also led to ERK hyperactivation upon insulin/IGF stimulation. Conversely, overexpression of Grb10 in HEK293 cells substantially interfered with activation of PI3K, as judged by decreased Akt T308 phosphorylation ( FIG. 10A ). The observed inhibition was not affected by the phosphorylation status of S501/S503. Previous work demonstrated that Grb10 interferes with insulin-mediated PI3K activation by binding to, and inhibiting, the insulin receptor (11). We confirmed this observation and demonstrated that Grb10 overexpression interferes with insulin receptor-dependent IRS phosphorylation and subsequent PI3K recruitment ( FIGS. 10B ,  10 C and  10 D). 
     The current model of the negative feedback loop from mTORC1 to PI3K involves S6K-mediated phosphorylation and subsequent degradation of IRS 1/2 (6). However, it has also been shown that overexpression of a dominant-negative, kinase-deficient S6K1 failed to completely recapitulate the hyperactivation of Akt induced by overexpression of kinase-dead mTOR, suggesting mTORC1 is directly involved in modulating this feedback inhibition loop (17). Our data clearly show that hyperactivation of mTORC1/S6K promotes feedback loop inhibition of PI3K through a two-prong mechanism: (1) mTORC1/S6K-mediated phosphorylation and degradation of a positive regulator of PI3K signaling, IRS, and (2) mTORC1-mediated phosphorylation and accumulation of a negative regulator of PI3K signaling, Grb10. 
     Numerous genetic alterations in cancers result in hyperactivation of the mTOR complexes. Based on these observations, rapamycin analogues are currently approved, or being assessed in various clinical trials, as targeted therapeutics against several cancer subtypes. However, with a few exceptions, the current results have been disappointing, as the clinical outcome of rapamycin treatment is unpredictable and rapamycin is largely ineffective as a monotherapy (3). In particular, it has been shown that post-surgical, maintenance rapamycin treatment led to PI3K/Akt activation in glioblastoma patients, and this activation was associated with shorter time-to-progression (4). We asked whether PI3K hyperactivation induced by Grb10 knockdown (which phenotypically mimics rapamycin-induced Grb10 depletion) would contribute to the survival of cells undergoing stress-induced apoptosis. In response to either staurosporine or etoposide, reduced caspase 3 cleavage was observed in Grb10 knockdown cells compared to control cells. These results indicate that Grb10 depletion is sufficient to protect cells from apoptosis ( FIGS. 4B and 10E ). Combined with the recent finding that rapamycin can protect cells from energy stress-induced death (18), these results provide a plausible mechanism as to why the effect of rapamycin therapy is cytostatic rather than cytotoxic in some types of cancers and suggest a complete understanding of the feedback inhibition control will be critical in designing combination therapy involving rapamycin and DNA-damaging reagents or reagents targeting metabolic pathways. 
     To explore the role of Grb10 in cancer progression, we performed a comprehensive meta-analysis of GRB10 expression based on published microarray data. GRB10 expression is significantly down-regulated in many tumor types compared to their normal tissue counterparts ( FIG. 4C ). The most profound down-regulation was observed in infiltrating bladder urothelial carcinoma, glioblastoma, breast, myeloma, prostate and pancreatic cancers. Given that loss of Grb10 results in a dramatic activation of the PI3K/Akt pathway ( FIG. 4A ), we performed correlation analysis between variations in the expression of GRB10 and PTEN, a known negative regulator of the PI3K/Akt pathway and tumor suppressor gene. While both GRB10 and PTEN are ubiquitously down-regulated, in all cases there was a significantly (p&lt;0.05) negative correlation between GRB10 and PTEN expression. The most striking differences were observed in breast carcinoma (Pearson correlation coefficient=−0.7, p=0.02) and myeloma (Pearson correlation coefficient=−0.82, p=0.001) ( FIG. 4D ). The data suggest that GRB10 loss provides an alternative mechanism of PI3K/Akt activation when PTEN expression is retained. It is particularly compelling that this correlation is only observed in tumor samples but not the normal tissue controls ( FIG. 4E ). It has been previously reported that PIK3CA mutations and PTEN loss are mutually exclusive in breast cancer (19), suggesting that an increased level of PIP 3  resulting from of genetic alteration of either PIK3CA or PTEN relieves selective pressure targeting the other gene. Similarly, Grb10 loss, which results in PI3K hyperactivation, might provide the cells with growth and survival advantages that are redundant with respect to PTEN loss-of-function, suggesting that Grb10 might be a novel tumor suppressor that is regulated by mTORC1. These data point to the exciting therapeutic prospects of targeting Grb10 stability in cancer therapy. 
     Materials and Methods 
     Cells and Reagents 
     Human embryonic kidney (HEK) 293E cells, immortalized wild-type mouse embryonic fibroblast (MEF) cells and TSC2−/− MEFs (a kind gift from David Kwiatkowski, Brigham and Women&#39;s Hospital) were maintained in Dulbecco&#39;s modified Eagle&#39;s medium (DMEM) supplemented with 10% fetal bovine serum. In collaboration with Millipore Inc., we generated anti-phospho-5501/S503-Grb10 antibodies. Anti-mTOR, anti-phospho-mTOR (S2481), anti-Grb10 (human), anti-phospho-Akt (S473), anti-phospho-Akt (T308), anti-Akt, anti-S6K, anti-phospho-S6K (T389), anti-IRS2, anti-PARP, anti-caspase 3, anti-4EBP, anti-4EBP (T37/T46), anti-phospho-ribosomal protein S6 (S235/S236), and anti-ribosomal protein S6 antibodies were obtained from Cell Signaling Technology. Anti-phospho-ERK1/2 antibody, insulin, Phorbol Myristate Acetate (PMA), Epidermal Growth Factor (EGF) and polybrene were purchased from Sigma. Anti-Grb10 (mouse), anti-phospho-IRS (Y612), anti-p85 and anti-p110 of PI3K antibodies were purchased from Santa Cruz, Invitrogen, Millipore and BD, respectively. ERK1/2 antibody and anti-HA antibody were prepared in the lab. LY294002 and AktVIII inhibitor were purchased from Calbiochem. Lipofectamine 2000 was purchased from Invitrogen. Torin was kindly provided by Nathanael Gray (Dana Farber Cancer Institute). 
     SILAC Cell Culture 
     TSC2−/− MEFs were used in the rapamycin screen due to constitutive hyperactivation of mTORC1 signaling in this cell line. Cells were grown in light ([ 12 C 6   14 N 2 ]Lys, [ 12 C 6   14 N 4 ]Arg) and heavy ([ 13 C 6   15 N 2 ]Lys, [ 13 C 6   15 N 4 ]Arg) DMEM (Cambridge Isotope Labs), respectively. Both light and heavy DMEM were supplemented with 10% dialyzed FBS (Invitrogen). Cells were serum-deprived for 17 hours and cells were cultured inheavy media were treated with 20 nM rapamycin for two hours. We performed two biological replicates of this experimental design with cross-labeling (swapping the labeled state of the rapamycin-treated cells). For the purposes of illustration, the data for biological replicate #2 is presented in  FIGS. 1A and 1D . 
     The Ku-0063794 screen was performed using wild-type (WT) MEFs. Cells were grown in the aforementioned SILAC media. Both the light and heavy cells were starved of serum for 17 hrs. The light cells were treated with 20 nM rapamycin for 2 hrs, while the heavy cells were treated with a combination of 20 nM rapamycin and 2 μM Ku-0063794 for 2 hrs. Both the light and heavy cells were then stimulated with 100 nM insulin for 15 min. 
     Sample Preparation for Mass Spectrometric Analysis 
     The heavy and light cells were lysed in urea buffer (8 M urea, 20 mM HEPES pH 7.0, 75 mM β-glycerolphosphate, 1 mM sodium vanadate, 1 mM DTT and 1.5 mM EGTA) and the lysates were combined at a 1:1 ratio. Lysates were reduced by adding DTT to a final concentration of 3 mM, followed by incubation at room temperature for 20 min. Cysteines were alkylated by adding iodoacetamide to a final concentration of 50 mM, followed by incubation in the dark for 20 min. The lysates were diluted to a final concentration of 2 M urea by addition of 100 mM NH 4 OAC and were digested overnight with sequencing-grade trypsin (Promega) at a 1:100 (enzyme:substrate) ratio. Digestion was quenched by addition of trifluoroacetic acid to a final concentration of 0.1% and precipitates were removed by centrifugation at 4,000 rpm for 30 min. Peptides were desalted on SepPak C18 columns (Waters) according to manufacturer&#39;s instructions. 
     Phosphopeptides were enriched by SCX-IMAC (27). Briefly, lyophilized peptides were resuspended in 500 μl SCX buffer A (5 mM KH 2 PO 4 , pH 2.65, 30% acetonitrile) and injected onto a SCX column (Polysulfoethyl aspartamide, 9.4 mm×200 mm, 5 μM particle size, 200 Å pore size, PolyLC). Gradient was developed over 35 min ranging from 0% to 21% buffer B (5 mM KH 2 PO 4 , pH 2.65, 30% acetonitrile, 350 mM KCl) at a flow rate of 2 ml/min. Twelve fractions were collected and lyophilized. Peptides were then desalted using SepPak C18 columns and were subjected to IMAC (Sigma) for phosphopeptide enrichment. The eluate was further desalted using STAGE tips (28) and lyophilized. 
     Mass Spectrometry Analysis and Data Processing 
     The rapamycin screen samples were analyzed by LC-MS/MS on an LTQ-Orbitrap mass spectrometer (Thermo, San Jose, Calif.) using the top ten method. The Ku-0063794 screen samples were analyzed on an LTQ-Velos mass spectrometer (Thermo Fischer Scientific, San Jose, Calif.) using the top twenty method. MS/MS spectra were searched against a composite database of the mouse IPI protein database (Version 3.60) and its reversed complement using the Sequest algorithm. Search parameters allowed for a static modification of 57.02146 Da for Cys and a dynamic modification of phosphorylation (79.96633 Da) on Ser, Thr and Tyr, oxidation (15.99491 Da) on Met, stable isotope (10.00827 Da) and (8.01420 Da) on Arg and Lys, respectively. Search results were filtered to include &lt;1% matches to the reverse data base by the linear discriminator function (Huttlin et al., manuscript in preparation) using parameters including Xcorr, dCN, missed cleavage, charge state (exclude 1+ peptides), mass accuracy, peptide length and fraction of ions matched to MS/MS spectra. Phosphorylation site localization was assessed by the Ascore algorithm (29) based on the observation of phosphorylation-specific fragment ions and peptide quantification was performed by using the Vista algorithm (30, 31). 
     We further filter the peptides according to the following criteria for quantitation of the peptide abundance changes: (1) Vista confidence score must be at least 85, (2) signal to noise ratio (S/N)≧3 for both the heavy and light peptides, (3) in the cases where one of the isotopic species has an S/N of ≦3, S/N of the other was required to be ≧5, and (4) in the cases where only the heavy or light version of a peptide was found, we reported the peak S/N ratio, or its inverse, as a proxy for relative abundance measurement. For such peptides, we also required S/N of at ≧5 for the observed species. 
     Plasmids 
     The cDNA for human Grb10 (NCBI gene symbol GRB10; Gene ID: 2887) was obtained from Invitrogen and amplified by PCR. The product was subcloned into (1) the BamH I and EcoR I sites of pKH3, (2) the BamH I and EcoR I sites of pGEX-4T-3 or (3) the Hind III and EcoR I sites of pLPCX. The Grb10 point mutant constructs were generated using the QuickChange site-directed mutagenesis kit (Stratagene). pRK5-Myc-raptor andpRK5-Myc-Rictor were kindly provided by David Sabatini (MIT). Lentiviral plasmids (Δ8.9 and VSVG) were kind gifts from Andrew Kung (Dana Farber Cancer Institute) and David Baltimore (California Institute of Technology). 
     Immunoprecipitation 
     Cells were extracted with lysis buffer A (40 mM HEPES, pH 7.5, 120 mM NaCl, 1 mM EDTA, 10 mM β-glycerophosphate, 50 mM NaF, 2 mM phenylmethylsulfonyl fluoride, 2 mg/ml aprotinin, 2 mg/ml leupeptin, and 1 mg/ml pepstatin, 1 mM DTT) containing 1% Triton X-100, 1% NP-40, or 0.2% CHAPS. After centrifugation, supernatants were collected and pre-cleared for 1 h with protein A- and G-Sepharose beads (GE Healthcare Biosciences). After centrifugation at 3,000 rpm for 5 min, the supernatants were incubated with the antibody at 4° C. for 2 h, and then incubated with protein A- and G-Sepharose for an additional hour. Beads were washed four times with the lysis buffer and eluted in 2× reducing sample buffer. 
     Mammalian Lentiviral shRNAs 
     Lentiviral short hairpin RNA (shRNA) expression vectors were a kind gift from William Hahn (Dana Farber Cancer Institute). To generate the lentiviruses, shRNA plasmids were co-transfected into HEK293TD cells along with packaging (Δ8.9) and envelope (VSVG) expression plasmids using lipofectamine 2000 (Invitrogen). Two days after transfection, viral supernatants were harvested and filtered. Recipient cells were infected in the presence of a serum-containing medium supplemented with 8 μg/ml polybrene. Following infection for 36 h, cells were treated with 2.0 μg/ml puromycin (Sigma) and cell lines that stably expressed the shRNAs were selected. Knockdown efficiencies were examined by immunoblot assay using antibodies against the target protein. 
     Immunoblot Analysis 
     For immunoblot analysis, the cells were extracted in lysis buffer (20 mM HEPES (pH 7.5), 1% Triton X-100, 150 mM NaCl, 10 mM EDTA, 1 mM EGTA, 1 mM sodium orthovanadate, 1 mM NaF, 2 mM phenylmethylsulfonyl fluoride, 2 mg/ml aprotinin, 2 mg/ml leupeptin, and 1 mg/ml pepstatin), and extracts were mixed with the 5× reducing buffer (60 mM Tris-HCl, pH 6.8, 25% glycerol, 2% SDS, 14.4 mM 2-mercaptoethanol, 0.1% bromophenol blue). Samples were boiled for 5 min and subject to electrophoresis using the standard SDS-PAGE method. Proteins were then transferred to a nitrocellulose membrane (Whatman). The membranes were blocked with a TBST buffer (25 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.05% Tween 20) containing 3% nonfat dried milk, and probed overnight with primary antibodies at 4° C. and for 1 h at RT with peroxidase-conjugated secondary antibodies. Blots were developed using enhanced chemiluminescence, exposed on autoradiograph film and developed using standard methods. 
     Recombinant Protein Purification 
     For the purification of GST-tagged proteins, plasmids were transformed into  Escherichia coli  strain BL21 (DE3), and purified to homogeneity from crude lysates using glutathione-sepharose beads (GE Healthcare) according to the manufacture&#39;s protocol. Briefly, protein production was initiated by adding isopropyl-D-thiogalactopyranoside (Sigma) to the cultures. Bacteria were collected by centrifugation, resuspended in PBS and lysed by sonication. After centrifugation at 13,000 rpm for 15 min, the supernatant was incubated with glutathione-sepharose beads for 1 h. The beads were washed with PBS three times and the recombinant protein was eluted with PBS containing 20 mM reduced glutathione. Proteins were dialyzed against PBS and stored at −80° C. until use. 
     Quantitative RT-PCR Analysis 
     Total cellular RNA was purified from cultured cells using the RNeasy mini kit (Qiagen) following the manufacturer&#39;s protocol. For quantitative real-time PCR (qRT-PCR), RNA was reverse-transcribed using the High-Capacity cDNA Reverse Transcription Kit (Applied Biosystems) according to the manufacturer&#39;s instructions. The resulting cDNA was analyzed by qRT-PCR using the QuantiTect SYBR Green qPCR System (Qiagen). A QuantiTect Primer Assay for mouse Grb10 was used to amplify the target gene, while the β-acting primers (β-actin forward, ACCCAGATCATGTTTGAGACCT (SEQ ID NO: 25); and β-actin reverse, GCAGTAATCTCCTTCTGCATCC (SEQ ID NO: 26)) were used as a normalization control. All reactions were run on an ABI 7900HT Fast Real-Time PCR instrument with a 15 min hot start at 95° C. followed by 40 cycles of a 3-step thermocycling program: denaturation: 15 s at 94° C., annealing: 30 s at 55° C. and extension: 30 s at 70° C. Melting curve analysis was performed at the end of every run to ensure that a single PCR product of the expected melting temperature was produced in a given well. A total of 3 biological replicates×4 technical replicates/biological replicate were performed for each treatment group. Data analysis utilized the comparative C t  method (ΔΔC t  method). 
     Analysis of GRB10 and PTEN Expression in Human Samples. 
     Microarray expression data from six independent data sets corresponding to patient samples from bladder (GSE3167), glioblastoma (GSE4536), breast (GSE5764), myeloma (GSE5900), pancreatic (GSE1542) carcinoma and matching normal tissues were downloaded from Gene Expression Omnibus (www.nebi.nlm.nih.gov/geo/) and for prostate carcinoma from the Broad Institute cancer program datasets (www.broadinstitute.org/cgi-bin/cancer/datasets.cgi). The correlation in the gene expression between GRB10 and PTEN was performed using Pearson&#39;s correlation coefficient analysis and the samples were clustered using the Euclidean distance metric and Ward&#39;s linkage algorithm. 
     REFERENCES 
     
         
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         11. M. A. Lim, H. Riedel, F. Liu,  Front Biosci  9, 387 (2004). 
         12. A. Y. Choo, S. O. Yoon, S. G. Kim, P. P. Roux, J. Blenis,  Proc Natl Acad Sci USA  105, 17414 (2008). 
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     INCORPORATION BY REFERENCE 
     All publications, patents and sequence database entries mentioned herein, including those items listed below and in the databases and tables provided or referred to herein, are hereby incorporated by reference in their entirety for disclosure of the relevant subject matter indicated, as if each individual database entry, publication, or patent was specifically and individually indicated to be incorporated by reference. The specification provides a number of International Protein Index (IPI) accession numbers, starting with IPI followed by a number. International Protein Index database entries identified by IPI accession number in the specification are incorporated by reference for disclosure of the respective protein sequence and accompanying protein information. The IPI database can be accessed at the European Bioinformatics Institute homepage (www.ebi.ac.uk/), for example, at (www.ebi.ac.uk/IPI/IPIhelp.html). In case of conflict, the present application, including any definitions herein, will control. 
     EQUIVALENTS AND SCOPE 
     Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. The scope of the present invention is not intended to be limited to the above description, but rather is as set forth in the appended claims. 
     In the claims articles such as “a,” “an,” and “the” may mean one or more than one unless indicated to the contrary or otherwise evident from the context. Claims or descriptions that include “or” between one or more members of a group are considered satisfied if one, more than one, or all of the group members are present in, employed in, or otherwise relevant to a given product or process unless indicated to the contrary or otherwise evident from the context. The invention includes embodiments in which exactly one member of the group is present in, employed in, or otherwise relevant to a given product or process. The invention also includes embodiments in which more than one, or all of the group members are present in, employed in, or otherwise relevant to a given product or process. Furthermore, it is to be understood that the invention encompasses all variations, combinations, and permutations in which one or more limitations, elements, clauses, descriptive terms, etc., from one or more of the claims or from relevant portions of the description is introduced into another claim. For example, any claim that is dependent on another claim can be modified to include one or more limitations found in any other claim that is dependent on the same base claim. Furthermore, where the claims recite a composition, it is to be understood that methods of using the composition for any of the purposes disclosed herein are included, and methods of making the composition according to any of the methods of making disclosed herein or other methods known in the art are included, unless otherwise indicated or unless it would be evident to one of ordinary skill in the art that a contradiction or inconsistency would arise. For example, it is to be understood that any of the compositions of the invention can be used for vocal cord repair or other soft tissue repair or augmentation. It is also to be understood that any of the compositions made according to the methods for preparing compositions disclosed herein can be used for vocal cord repair or other soft tissue repair or augmentation. In addition, the invention encompasses compositions made according to any of the methods for preparing compositions disclosed herein. 
     Where elements are presented as lists, e.g., in Markush group format, it is to be understood that each subgroup of the elements is also disclosed, and any element(s) can be removed from the group. It is also noted that the term “comprising” is intended to be open and permits the inclusion of additional elements or steps. It should be understood that, in general, where the invention, or aspects of the invention, is/are referred to as comprising particular elements, features, steps, etc., certain embodiments of the invention or aspects of the invention consist, or consist essentially of, such elements, features, steps, etc. For purposes of simplicity those embodiments have not been specifically set forth in haec verba herein. Thus for each embodiment of the invention that comprises one or more elements, features, steps, etc., the invention also provides embodiments that consist or consist essentially of those elements, features, steps, etc. 
     Where ranges are given, endpoints are included. Furthermore, it is to be understood that unless otherwise indicated or otherwise evident from the context and/or the understanding of one of ordinary skill in the art, values that are expressed as ranges can assume any specific value within the stated ranges in different embodiments of the invention, to the tenth of the unit of the lower limit of the range, unless the context clearly dictates otherwise. It is also to be understood that unless otherwise indicated or otherwise evident from the context and/or the understanding of one of ordinary skill in the art, values expressed as ranges can assume any subrange within the given range, wherein the endpoints of the subrange are expressed to the same degree of accuracy as the tenth of the unit of the lower limit of the range. 
     In addition, it is to be understood that any particular embodiment of the present invention may be explicitly excluded from any one or more of the claims. Any embodiment, element, feature, application, or aspect of the compositions and/or methods of the invention, can be excluded from any one or more claims. For purposes of brevity, all of the embodiments in which one or more element, feature, purpose, or aspect is excluded are not set forth explicitly herein. 
     TABLES 
     The Tables provided below are referred to in the specification and the claims. Because some of the tables are lengthy, they are provided in this subsection. 
     
       
         
           
               
               
             
               
                 TABLE 1 
               
               
                   
               
               
                 Gene Symbol 
                 Annotation 
               
               
                   
               
             
            
               
                 1110013L07Rik 
                 Putative uncharacterized protein 
               
               
                 1600027N09Rik 
                 RIKEN cDNA 1600027N09 gene 
               
               
                 2610110G12Rik 
                 Isoform 1 of UPF0635 protein C6orf134 homolog 
               
               
                 Aak1 
                 Isoform 2 of AP2-associated protein kinase 1 
               
               
                 Adamts2 
                 A disintegrin and metalloproteinase with thrombospondin motifs 2 
               
               
                 Ahctf1 
                 AT-hook-containing transcription factor 1 
               
               
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
               
               
                 Aim1l 
                 Absent in melanoma 1-like 
               
               
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
               
               
                 Alkbh6 
                 24 kDa protein 
               
               
                 Arhgap17 
                 Isoform 1 of Rho GTPase-activating protein 17 
               
               
                 Atg2a 
                 Autophagy-related protein 2 homolog A 
               
               
                 B230208H17Rik 
                 Putative GTP-binding protein Parf 
               
               
                 Bat2l 
                 Isoform 1 of Protein BAT2-like 
               
               
                 Bcas3 
                 Isoform 1 of Breast carcinoma-amplified sequence 3 homolog 
               
               
                 Bclaf1 
                 Isoform 2 of Bcl-2-associated transcription factor 1 
               
               
                 Bcr 
                 Breakpoint cluster region protein 
               
               
                 Bmp2k 
                 Isoform 1 of BMP-2-inducible protein kinase 
               
               
                 Bod1l 
                 biorientation of chromosomes in cell division 1-like 
               
               
                 C130092O11Rik 
                 Isoform 1 of Uncharacterized protein KIAA1680 
               
               
                 Cabin1 
                 calcineurin binding protein 1 
               
               
                 Carhspl 
                 Calcium-regulated heat stable protein 1 
               
               
                 Ccdc6 
                 coiled-coil domain containing 6 
               
               
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
               
               
                 Cd2ap 
                 CD2-associated protein 
               
               
                 Cdgap 
                 Cdc42 GTPase-activating protein 
               
               
                 Chd1 
                 Chromodomain-helicase-DNA-binding protein 1 
               
               
                 Crkrs 
                 Isoform 2 of Cell division cycle 2-related protein kinase 7 
               
               
                 Cttn 
                 Src substrate cortactin 
               
               
                 Cux1 
                 cut-like homeobox 1 isoform a 
               
               
                 D6Wsu116e 
                 Isoform 1 of Protein FAM21 
               
               
                 D830015G02Rik 
                 Putative uncharacterized protein 
               
               
                 Dab2 
                 Isoform p93 of Disabled homolog 2 
               
               
                 Ddx21 
                 Nucleolar RNA helicase 2 
               
               
                 Dennd4a 
                 hypothetical protein LOC102442 
               
               
                 Dhx15 
                 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 
               
               
                 Dnajc2 
                 DnaJ homolog subfamily C member 2 
               
               
                 Dock11 
                 Dedicator of cytokinesis protein 11 
               
               
                 Edc3 
                 Enhancer of mRNA-decapping protein 3 
               
               
                 Edc4 
                 Isoform 1 of Enhancer of mRNA-decapping protein 4 
               
               
                 Eef2k 
                 Elongation factor 2 kinase 
               
               
                 Ehbp1 
                 Isoform 2 of EH domain-binding protein 1 
               
               
                 Ehmt2 
                 Isoform 1 of Histone-lysine N-methyltransferase H3 lysine-9 specific 3 
               
               
                 Eif3a 
                 Eukaryotic translation initiation factor 3 subunit A 
               
               
                 Eif4b 
                 Eukaryotic translation initiation factor 4B 
               
               
                 Eif4ebp1 
                 Eukaryotic translation initiation factor 4E-binding protein 1 
               
               
                 Eif4ebp2 
                 Eukaryotic translation initiation factor 4E-binding protein 2 
               
               
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation initiation factor 4 gamma 1 
               
               
                 Eif5; LOC100047658 
                 Eukaryotic translation initiation factor 5 
               
               
                 Emg1 
                 Probable ribosome biogenesis protein NEP1 
               
               
                 Eps8l2 
                 Isoform 1 of Epidermal growth factor receptor kinase substrate 8-like protein 2 
               
               
                 Epyc 
                 Epiphycan 
               
               
                 Erc1; LOC100048600 
                 Isoform 1 of ELKS/RAB6-interacting/CAST family member 1 
               
               
                 Ext1 
                 Exostosin-1 
               
               
                 Fbxw9 
                 F-box and WD-40 domain protein 9 
               
               
                 Fkbp15 
                 Isoform B of FK506-binding protein 15 
               
               
                 FLNA 
                 Filamin-A 
               
               
                 Fmnl3 
                 Isoform 1 of Formin-like protein 3 
               
               
                 Foxk1 
                 Forkhead box protein K1 
               
               
                 Foxk2 
                 Isoform 1 of Forkhead box protein K2 
               
               
                 Fxr1 
                 Isoform E of Fragile X mental retardation syndrome-related protein 1 
               
               
                 Gbf1 
                 Golgi-specific brefeldin A-resistance factor 1 
               
               
                 Gm13099 
                 Novel protein similar to preferentially expressed antigen in melanoma-like family 
               
               
                 Gm13697 
                 Novel protein containing MIF4G and MA3 domains 
               
               
                 Gm14085 
                 Novel protein similar to solute carrier family 28 (Sodium-coupled nucleoside 
               
               
                   
                 transporter) member 2 
               
               
                 Gm6988 
                 similar to hCG1640785 
               
               
                 Gm9757 
                 Putative uncharacterized protein 
               
               
                 Gon4l 
                 RIKEN cDNA 5830417110 gene 
               
               
                 Grb10 
                 Isoform 3 of Growth factor receptor-bound protein 10 
               
               
                 Gsk3b 
                 Glycogen synthase kinase-3 beta 
               
               
                 Gtf2f1 
                 General transcription factor IIF subunit 1 
               
               
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth factor-related protein 2 
               
               
                 Herc1 
                 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 
               
               
                   
                 (CHC1)-like domain (RLD) 1 
               
               
                 Hisppd1 
                 140 kDa protein 
               
               
                 Hn1l 
                 Hematological and neurological expressed 1-like protein 
               
               
                 Ibtk 
                 Isoform 2 of Inhibitor of Bruton tyrosine kinase 
               
               
                 Inf2 
                 Isoform 1 of Inverted formin-2 
               
               
                 Iqsec1 
                 IQ motif and Sec7 domain 1 isoform b 
               
               
                 Irs2 
                 Insulin receptor substrate 2 
               
               
                 Iws1 
                 Isoform 1 of Protein IWS1 homolog 
               
               
                 Junb 
                 Transcription factor jun-B 
               
               
                 Kdm3b 
                 Isoform 2 of Lysine-specific demethylase 3B 
               
               
                 Kdm6a 
                 Isoform 1 of Lysine-specific demethylase 6A 
               
               
                 Ktn1 
                 Isoform 1 of Kinectin 
               
               
                 Larp1 
                 Isoform 1 of La-related protein 1 
               
               
                 Larp4 
                 Putative uncharacterized protein 
               
               
                 Larp7 
                 Isoform 1 of La-related protein 7 
               
               
                 Ldhd 
                 22 kDa protein 
               
               
                 Lin9 
                 lsoform 2 of Lin-9 homolog 
               
               
                 Llgl1 
                 lethal giant larvae homolog 1 isoform 1 
               
               
                 LOC100048123; Akt2 
                 RAC-beta serine/threonine-protein kinase 
               
               
                 LOC100048559; Sfrs1 
                 Isoform 1 of Splicing factor arginine/serine-rich 1 
               
               
                 Luc7l2 
                 Isoform 1 of Putative RNA-binding protein Luc7-like 2 
               
               
                 Macf1 
                 Isoform 3 of Microtubule-actin cross-linking factor 1 
               
               
                 Med1 
                 Isoform 4 of Mediator of RNA polymerase II transcription subunit 1 
               
               
                 Megf11 
                 Isoform 4 of Multiple epidermal growth factor-like domains 11 
               
               
                 Mett10d 
                 Isoform 1 of Putative methyltransferase METT10D 
               
               
                 Mib1 
                 E3 ubiquitin-protein ligase MIB1 
               
               
                 Micall1 
                 Isoform 1 of MICAL-like protein 1 
               
               
                 Mll2 
                 similar to myeloid/lymphoid or mixed-lineage leukemia 2 
               
               
                 Mllt4 
                 Isoform 3 of Afadin 
               
               
                 Mogat1 
                 2-acylglycerol O-acyltransferase 1 
               
               
                 Mtap1b 
                 Microtubule-associated protein 1B 
               
               
                 Mtor 
                 Isoform 1 of FKBP12-rapamycin complex-associated protein 
               
               
                 Myef2 
                 Isoform 2 of Myelin expression factor 2 
               
               
                 Myo5a 
                 Myosin-Va 
               
               
                 Nacc1 
                 Nucleus accumbens-associated protein 1 
               
               
                 Ndrg3 
                 Protein NDRG3 
               
               
                 Nfic 
                 Isoform 1 of Nuclear factor 1 C-type 
               
               
                 Npm1 
                 Nucleophosmin 
               
               
                 Numa1 
                 Nuclear mitotic apparatus protein 1 
               
               
                 Palm 
                 Isoform 1 of Paralemmin 
               
               
                 Patl1 
                 Protein PAT1 homolog 1 
               
               
                 Pbx2 
                 Pre-B-cell leukemia transcription factor 2 
               
               
                 Pcbp1 
                 Poly(rC)-binding protein 1 
               
               
                 Pcbp2 
                 Isoform 1 of Poly(rC)-binding protein 2 
               
               
                 Pcm1 
                 Isoform 1 of Pericentriolar material 1 protein 
               
               
                 Pdcd11 
                 Protein RRP5 homolog 
               
               
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion protein PDS5 homolog B 
               
               
                 Peg3 
                 Isoform 1 of Paternally-expressed gene 3 protein 
               
               
                 Pgrmc2 
                 Membrane-associated progesterone receptor component 2 
               
               
                 Phf3 
                 PHD finger protein 3 
               
               
                 Phldb1 
                 Isoform 2 of Pleckstrin homology-like domain family B member 1 
               
               
                 Phldb2 
                 lsoform 1 of Pleckstrin homology-like domain family B member 2 
               
               
                 Pi4k2a 
                 Phosphatidylinositol 4-kinase type 2-alpha 
               
               
                 Pkn2 
                 Isoform 1 of Serine/threonine-protein kinase N2 
               
               
                 Pla2g4a 
                 Cytosolic phospholipase A2 
               
               
                 Plekhm1 
                 Pleckstrin homology domain-containing family M member 1 
               
               
                 Pom121 
                 Nuclear envelope pore membrane protein POM 121 
               
               
                 Ppfibp2 
                 Isoform 4 of Liprin-beta-2 
               
               
                 Ppp1r12a 
                 MCG122391 isoform CRA_e 
               
               
                 Prkd2 
                 Serine/threonine-protein kinase D2 
               
               
                 Ptk2 
                 Isoform 1 of Focal adhesion kinase 1 
               
               
                 Qsox2 
                 Isoform 3 of Sulfhydryl oxidase 2 
               
               
                 Rab1 
                 Ras-related protein Rab-1A 
               
               
                 Ranbp10 
                 Ran-binding protein 10 
               
               
                 Ranbp9 
                 RAN binding protein 9 
               
               
                 Rb1 
                 Retinoblastoma-associated protein 
               
               
                 Rfc1 
                 Rfc1 protein 
               
               
                 Rictor 
                 Isoform 1 of rapamycin-insensitive companion of mTOR 
               
               
                 Rnf19b 
                 IBR domain containing 3 
               
               
                 Rps6 
                 29 kDa protein 
               
               
                 Rps6kb1 
                 Isoform Alpha I of Ribosomal protein S6 kinase beta-1 
               
               
                 RsI1d1 
                 Putative uncharacterized protein 
               
               
                 rsp6 
                 29 kDa protein 
               
               
                 Sap30 
                 Histone deacetylase complex subunit SAP30 
               
               
                 Sbno1 
                 Isoform 2 of Protein strawberry notch homolog 1 
               
               
                 Scrib 
                 Isoform 1 of Protein LAP4 
               
               
                 Serbp1 
                 Isoform 1 of Plasminogen activator inhibitor 1 RNA-binding protein 
               
               
                 Setd1a 
                 SET domain containing 1A 
               
               
                 Sfrs18 
                 splicing factor arginine/serine-rich 18 
               
               
                 Sfrs8 
                 splicing factor arginine/serine-rich 8 
               
               
                 Sgta 
                 Isoform 1 of Small glutamine-rich tetratricopeptide repeat-containing protein alpha 
               
               
                 Slc4a1ap 
                 solute carrier family 4 (anion exchanger) member 1 adaptor protein 
               
               
                 Smarca4 
                 Putative uncharacterized protein 
               
               
                 Smarcad1 
                 Isoform 1 of SWI/SNF-related matrix-associated actin-dependent regulator of 
               
               
                   
                 chromatin subfamily A containing DEAD/H box 1 
               
               
                 Smarcc2 
                 Isoform 2 of SWI/SNF complex subunit SMARCC2 
               
               
                 Snx17 
                 Sorting nexin-17 
               
               
                 Snx30 
                 Sorting nexin-30 
               
               
                 Sorbs3 
                 Vinexin 
               
               
                 Spna2 
                 Isoform 2 of Spectrin alpha chain brain 
               
               
                 Sqstm1 
                 Isoform 1 of Sequestosome-1 
               
               
                 Srpk2 
                 serine/arginine-rich protein-specific kinase 2 
               
               
                 Srrm1 
                 Isoform 2 of Serine/arginine repetitive matrix protein 1 
               
               
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive matrix protein 2 
               
               
                 St5 
                 Isoform 1 of Suppression of tumorigenicity 5 
               
               
                 Strn3 
                 Striatin-3 
               
               
                 Syap1 
                 Synapse-associated protein 1 
               
               
                 Tbc1d4 
                 140 kDa protein 
               
               
                 Tcfeb 
                 Transcription factor EB 
               
               
                 Tinf2 
                 Putative uncharacterized protein 
               
               
                 Tjp2 
                 Tight junction protein ZO-2 
               
               
                 Tmem106b 
                 Transmembrane protein 106B isoform CRA_b 
               
               
                 Tmpo 
                 Isoform Beta of Lamina-associated polypeptide 2 isoforms beta/delta/epsilon/gamma 
               
               
                 Tnc 
                 Isoform 1 of Tenascin 
               
               
                 Tns1 
                 tensin 1 
               
               
                 Tox4 
                 TOX high mobility group box family member 4 
               
               
                 Trim28 
                 Isoform 1 of Transcription intermediary factor 1-beta 
               
               
                 Trip10 
                 Isoform 3 of Cdc42-interacting protein 4 
               
               
                 Ubxn7 
                 UBX domain-containing protein 7 
               
               
                 Ulk1 
                 Putative uncharacterized protein 
               
               
                 Usp24 
                 Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 24 
               
               
                 Usp36 
                 Ubiquitin specific peptidase 36 
               
               
                 Uvrag 
                 UV radiation resistance associated 
               
               
                 Vwa5b1 
                 von Willebrand factor A domain-containing protein 5B1 
               
               
                 Wdr91 
                 WD repeat-containing protein 91 
               
               
                 Wnk1 
                 Serine/threonine-protein kinase WNK1 
               
               
                 Zc3h4 
                 Isoform 2 of Zinc finger CCCH domain-containing protein 4 
               
               
                 Zc3hc1 
                 Isoform 1 of Nuclear-interacting partner of ALK 
               
               
                 Zeb2 
                 Zinc finger E-box-binding homeobox 2 
               
               
                 Zfp106 
                 Isoform 1 of Zinc finger protein 106 
               
               
                 Zfp516 
                 Zinc finger protein 516 
               
               
                 Znrf2 
                 E3 ubiquitin-protein ligase ZNRF2 
               
               
                   
               
               
                 Table 1. Names and annotations of proteins identified to harbor phosphopeptides whose intensities decrease after rapamycin treatment (rapamycin screen). 
               
               
                 Note 
               
               
                 that the rapamycin screen included two biological replicates. For the first replicate, the light cells were controls whereas the heavy cells were treated with rapamycin. For the second replicate experiment, the light cells were treated with rapamycin, and the heavy cells were controls. Table 1 includes all unique proteins identified in both replicates. Protein sequences and phosphorylation sites can be identified from the identifiers provided in the tables and database provided herein. 
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 2 
               
               
                   
               
               
                 Gene Symbol 
                 Annotation 
               
               
                   
               
             
            
               
                 Myo18a 
                 Isoform 4 of Myosin-XVIIIa 
               
               
                 Brd2 
                 Isoform 2 of Bromodomain-containing protein 2 
               
               
                 6330577E15Rik 
                 Uncharacterized protein C10orf78 homolog 
               
               
                 Best3 
                 Bestrophin-3 
               
               
                 Larp1 
                 Isoform 1 of La-related protein 1 
               
               
                 Fam62c 
                 Isoform 1 of Extended synaptotagmin-3 
               
               
                 Mdn1 
                 Midasin homolog 
               
               
                 Rtn4 
                 Isoform 2 of Reticulon-4 
               
               
                 Pcdh24 
                 Pcdh24 protein 
               
               
                 Synj1 
                 similar to mKIAA0910 protein 
               
               
                 Zfp318 
                 zinc finger protein 318 isoform 1 
               
               
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
               
               
                 Alpk3 
                 myocyte induction differentiation originator 
               
               
                 Zc3h14 
                 Isoform 2 of Zinc finger CCCH domain-containing 
               
               
                   
                 protein 14 
               
               
                 Edc4 
                 Isoform 1 of Enhancer of mRNA-decapping 
               
               
                   
                 protein 4 
               
               
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive matrix 
               
               
                   
                 protein 2 
               
               
                 Kif20b 
                 Isoform 1 of M-phase phosphoprotein 1 
               
               
                 1110007A13Rik 
                 UPF0557 protein C10orf119 homolog 
               
               
                 Pi4k2a 
                 Phosphatidylinositol 4-kinase type 2-alpha 
               
               
                 Top2b 
                 DNA topoisomerase 2-beta 
               
               
                 BC021381 
                 Isoform 2 of Uncharacterized protein KIAA1931 
               
               
                 Bbx 
                 Isoform 1 of HMG box transcription factor BBX 
               
               
                 Vcl 
                 Vinculin 
               
               
                 Eif4ebp1 
                 Eukaryotic translation initiation factor 4E-binding 
               
               
                   
                 protein 1 
               
               
                 Rrp15 
                 RRP15-like protein 
               
               
                 D10Wsu102e 
                 Uncharacterized protein C12orf45 homolog 
               
               
                 Braf 
                 Isoform 1 of B-Raf proto-oncogene serine/ 
               
               
                   
                 threonine-protein kinase 
               
               
                 Atg2b 
                 Isoform 1 of Autophagy-related protein 2 
               
               
                   
                 homolog B 
               
               
                 Npm1 
                 Nucleophosmin 
               
               
                 Pcsk5 
                 proprotein convertase subtilisin/kexin type 5 
               
               
                 Mtap1b 
                 Microtubule-associated protein 1B 
               
               
                 Ercc6l 
                 DNA excision repair protein ERCC-6-like 
               
               
                 Serinc1 
                 Serine incorporator 1 
               
               
                 Klf3; LOC100046855 
                 Krueppel-like factor 3 
               
               
                 Smarca4 
                 Putative uncharacterized protein 
               
               
                 Aak1 
                 Uncharacterized protein FLJ45252 homolog 
               
               
                 Eif4ebp2 
                 Eukaryotic translation initiation factor 4E-binding 
               
               
                   
                 protein 2 
               
               
                 Ndrg1 
                 Protein NDRG1 
               
               
                 Melk 
                 Maternal embryonic leucine zipper kinase 
               
               
                 Arhgef17 
                 Isoform 1 of Rho guanine nucleotide exchange 
               
               
                   
                 factor 17 
               
               
                 Grit 
                 Isoform 2 of Rho/Cdc42/Rac GTPase-activating 
               
               
                   
                 protein RICS 
               
               
                 Mdc1 
                 mediator of DNA damage checkpoint 1 
               
               
                 Nfkb2 
                 NF-kB2 splice variant 4 
               
               
                 Pcm1 
                 Isoform 1 of Pericentriolar material 1 protein 
               
               
                 Mybbp1a 
                 Myb-binding protein 1A 
               
               
                 Sf3b1 
                 Splicing factor 3B subunit 1 
               
               
                 Atrx 
                 Transcriptional regulator ATRX 
               
               
                 Ccdc88a 
                 Isoform 2 of Girdin 
               
               
                 Baz1b 
                 Isoform 1 of Tyrosine-protein kinase BAZ1B 
               
               
                 Nedd4l 
                 Isoform 3 of E3 ubiquitin-protein ligase NEDD4- 
               
               
                   
                 like 
               
               
                 Orc6l 
                 Origin recognition complex subunit 6 
               
               
                 Trp53bp1 
                 Transformation related protein 53 binding protein 1 
               
               
                 Map3k2 
                 Mitogen-activated protein kinase kinase kinase 2 
               
               
                 Hectd2 
                 Hectd2 protein 
               
               
                 Usp10 
                 Ubiquitin carboxyl-terminal hydrolase 10 
               
               
                 D830031N03Rik 
                 similar to mKIAA0754 protein 
               
               
                 Nck1 
                 non-catalytic region of tyrosine kinase adaptor 
               
               
                   
                 protein 1 
               
               
                 Exosc9 
                 Exosome complex exonuclease RRP45 
               
               
                 Dap 
                 Death-associated protein 1 
               
               
                 Rps6kb1 
                 Isoform Alpha I of Ribosomal protein S6 kinase 
               
               
                   
                 beta-1 
               
               
                 Lmna 
                 Isoform C2 of Lamin-A/C 
               
               
                 Sltm 
                 Isoform 1 of SAFB-like transcription modulator 
               
               
                 Sh3pxd2a 
                 Isoform 1 of SH3 and PX domain-containing 
               
               
                   
                 protein 2A 
               
               
                 Flnc 
                 Isoform 1 of Filamin-C 
               
               
                 Oxr1 
                 Isoform 2 of Oxidation resistance protein 1 
               
               
                 Rin2 
                 Isoform 1 of Ras and Rab interactor 2 
               
               
                 Nek9 
                 Serine/threonine-protein kinase Nek9 
               
               
                 Pebp1 
                 Phosphatidylethanolamine-binding protein 1 
               
               
                 Pop1 
                 Processing of 1 ribonuclease P/MRP family 
               
               
                 Serhl 
                 Serine hydrolase-like protein 
               
               
                 Epb4.1l3 
                 Isoform 1 of Band 4.1-like protein 3 
               
               
                 Hnrpll 
                 Isoform 1 of Heterogeneous nuclear 
               
               
                   
                 ribonucleoprotein L-like 
               
               
                 Samhd1 
                 SAM domain and HD domain-containing protein 1 
               
               
                 Zfp828 
                 Zinc finger protein 828 
               
               
                 Larp7 
                 Isoform 1 of La-related protein 7 
               
               
                 Myc 
                 myc proto-oncogene protein 
               
               
                 Myo9a 
                 Isoform 2 of Myosin-IXa 
               
               
                 Gsk3b 
                 Glycogen synthase kinase-3 beta 
               
               
                 Zfp395 
                 zinc finger protein 395 
               
               
                 Bend3 
                 BEN domain-containing protein 3 
               
               
                 Akap12 
                 Isoform 1 of A-kinase anchor protein 12 
               
               
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation initiation factor 
               
               
                   
                 4 gamma 1 
               
               
                 Eif4b 
                 Eukaryotic translation initiation factor 4B 
               
               
                 Dock7 
                 Isoform 2 of Dedicator of cytokinesis protein 7 
               
               
                 Patl1 
                 Protein PAT1 homolog 1 
               
               
                 Slc7a11 
                 Cystine/glutamate transporter 
               
               
                 Myo9b 
                 Isoform 1 of Myosin-IXb 
               
               
                 Setd2 
                 SET domain containing 2 
               
               
                 Gphn 
                 Gephyrin 
               
               
                 Erf 
                 ETS domain-containing transcription factor ERF 
               
               
                 Spnb2 
                 Isoform 2 of Spectrin beta chain brain 1 
               
               
                 Phip 
                 PH-interacting protein 
               
               
                 Sdpr 
                 Serum deprivation-response protein 
               
               
                 Tcof1 
                 Treacle protein 
               
               
                 Pwp1 
                 Periodic tryptophan protein 1 homolog 
               
               
                 Rbl1 
                 Isoform Long of Retinoblastoma-like protein 1 
               
               
                 Eef1b2 
                 Elongation factor 1-beta 
               
               
                 Phactr4 
                 Isoform 1 of Phosphatase and actin regulator 4 
               
               
                 C230081A13Rik 
                 Tyrosine-protein kinase-protein kinase SgK269 
               
               
                 Ahnak2 
                 Putative uncharacterized protein 
               
               
                   
               
               
                 Table 2. Names and annotations of proteins identified to harbor phosphopeptides whose intensities decrease after Ku-0063794 treatment (Ku-0063794 screen). 
               
               
                 Note 
               
               
                 that the light cells were treated with rapamycin and serve as controls whereas the heavy cells were treated with a combination of rapamycin and Ku-0063794. Protein sequences and phosphorylation sites can be identified from the identifiers provided in the tables and the database provided herein. 
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 3 
               
               
                   
               
               
                   
                   
                 SEQ 
                   
                   
               
               
                   
                   
                 ID 
                 Gene 
               
               
                 IPI Reference 
                 Peptide 
                 NO 
                 Name 
                 Class 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 IPI00121418.1 
                 K.DGEGPDNLEPACPLSLPLQGNHTAADMYLS*PLRS*PK.K 
                 30 
                 Rb1 
                 1 
               
               
                   
               
               
                 IPI00221581.1 
                 R.TGS*ESS*QTGASATSGR.N 
                 31 
                 Eif4b 
                 1 
               
               
                   
               
               
                 IPI00929786.1 
                 R.TAS*ISSS*PSEGTPAVGSYGCT*PQS*LPK@.F 
                 32 
                 Larp1 
                 1 
               
               
                   
               
               
                 IPI00929786.1 
                 R.TAS*ISSS*PSEGTPAVGSYGCT*PQS*LPK@.F 
                 33 
                 Larp1 
                 1 
               
               
                   
               
               
                 IPI00929786.1 
                 R.T*AS*ISSSPSEGTPAVGS*YGCTPQSLPK@.F 
                 34 
                 Larp1 
                 1 
               
               
                   
               
               
                 IPI00317401.6 
                 R.AES*PETSAVESTQST*PQK@.G 
                 35 
                 Pds5b 
                 1 
               
               
                   
               
               
                 IPI00107958.1 
                 K.TSDIFGS*PVTATAPLAHPNK@PK@.D 
                 36 
                 Hn1l 
                 1 
               
               
                   
               
               
                 IPI00108454.2 
                 R.R{circumflex over ( )}LS*S*LR{circumflex over ( )}.A 
                 37 
                 Rps6 
                 1 
               
               
                   
               
               
                 IPI00225062.2 
                 R.R{circumflex over ( )}SS*SELS*PEVVEK@.V 
                 38 
                 Srrm2 
                 1 
               
               
                   
               
               
                 IPI00761759.1 
                 R.S*SSGS*EHST*EGSVSLGDGPLSR{circumflex over ( )}.S 
                 39 
                 Larp4 
                 1 
               
               
                   
               
               
                 IPI00761759.1 
                 R.SSS*GS*EHST*EGSVSLGDGPLSR{circumflex over ( )}.S 
                 40 
                 Larp4 
                 1 
               
               
                   
               
               
                 IPI00225062.2 
                 R.RSS*SELS*PEVVEK.V 
                 41 
                 Srrm2 
                 1 
               
               
                   
               
               
                 IPI00122594.4 
                 R.TTPLAS*PSLS*PGR{circumflex over ( )}.S 
                 42 
                 Ahctf1 
                 1 
               
               
                   
               
               
                 IPI00136107.1 
                 R.THS*TSS*S*IGSGESPFSR{circumflex over ( )}.S 
                 43 
                 Ndrg3 
                 1 
               
               
                   
               
               
                 IPI00136107.1 
                 R.THS*TSSS*IGSGESPFSR{circumflex over ( )}.S 
                 44 
                 Ndrg3 
                 1 
               
               
                   
               
               
                 IPI00136107.1 
                 R.THS*TSS*SIGSGESPFSR{circumflex over ( )}.S 
                 45 
                 Ndrg3 
                 1 
               
               
                   
               
               
                 IPI00136107.1 
                 R.THS*TSSSIGSGESPFSR{circumflex over ( )}.S 
                 46 
                 Ndrg3 
                 1 
               
               
                   
               
               
                 IPI00136107.1 
                 R.T*HST*S*SSIGSGESPFSR{circumflex over ( )}.S 
                 47 
                 Ndrg3 
                 1 
               
               
                   
               
               
                 IPI00136107.1 
                 R.T*HSTSSS*IGSGESPFSR{circumflex over ( )}.S 
                 48 
                 Ndrg3 
                 1 
               
               
                   
               
               
                 IPI00136107.1 
                 R.THS*TSSS*IGSGESPFSR{circumflex over ( )}.S 
                 49 
                 Ndrg3 
                 1 
               
               
                   
               
               
                 IPI00136107.1 
                 R.T*HSTSS*SIGSGESPFSR{circumflex over ( )}.S 
                 50 
                 Ndrg3 
                 1 
               
               
                   
               
               
                 IPI00136107.1 
                 R.THS*TSSSIGSGESPFSR{circumflex over ( )}.S 
                 51 
                 Ndrg3 
                 1 
               
               
                   
               
               
                 IPI00551454.3 
                 R.ER{circumflex over ( )}QES*ESEQELVNK@.R 
                 52 
                 Pdcd11 
                 1 
               
               
                   
               
               
                 IPI00117229.3 
                 R.TS*PAGGTWSSVVSGVPR.L 
                 53 
                 Atxn2 
                 1 
               
               
                   
               
               
                 IPI00348442.1 
                 R.SK@FDS*DEEDEDAENLEAVSSGK@.V 
                 54 
                 Sfrs18 
                 1 
               
               
                   
               
               
                 IPI00556837.1 
                 K.DTVIIVS*EPS*EDEESHDLPSVTR.R 
                 55 
                 Smarcad1 
                 1 
               
               
                   
               
               
                 IPI00153986.2 
                 K.GTS*RPGT*PSAEAASTSSTLR.A 
                 56 
                 Gtf2f1 
                 1 
               
               
                   
               
               
                 IPI00225062.2 
                 R.GCS*PPKS*PEKPPQSTSSESCPPS*PQPTK.V 
                 57 
                 Srrm2 
                 1 
               
               
                   
               
               
                 IPI00128904.1 
                 R.VMTIPYQPMPASS*PVICAGGQDR.C 
                 58 
                 Pcbp1 
                 1 
               
               
                   
               
               
                 IPI00121251.7 
                 R.LSTTPS*PT*NSLHEDGVDDFRR.Q 
                 59 
                 Tox4 
                 1 
               
               
                   
               
               
                 IPI00320594.5 
                 K.SQPHSSTSNQETS*DS*EMEMEAEHYPNGVLESVSTR{circumflex over ( )}.I 
                 60 
                 Ranbp10 
                 1 
               
               
                   
               
               
                 IPI00808277.2 
                 R.SAPASPNHAGVLS*AHS*SGAQTPESLS*R{circumflex over ( )}.E 
                 61 
                 Foxk2 
                 1 
               
               
                   
               
               
                 IPI00137166.1 
                 R.SR{circumflex over ( )}DAT*PPVS*PINMEDQER{circumflex over ( )}.I 
                 62 
                 Junb 
                 1 
               
               
                   
               
               
                 IPI00454104.1 
                 K.TTEAPCS*PGSQQPPS*PDELPANVK@.Q 
                 63 
                 Scrib 
                 1 
               
               
                   
               
               
                 IPI00225062.2 
                 R.GCS*PPK@S*PEK@PPQSTSSESCPPS*PQPTK@.V 
                 64 
                 Srrm2 
                 1 
               
               
                   
               
               
                 IPI00153986.2 
                 K.GTS*R{circumflex over ( )}PGTPS*AEAASTSSTLR{circumflex over ( )}.A 
                 65 
                 Gtf2f1 
                 1 
               
               
                   
               
               
                 IPI00753321.2 
                 K.SVS*ETSEDK@K@DEES*DEEEEEEEEEEPLGATTR{circumflex over ( )}.S 
                 66 
                 Bod1l 
                 1 
               
               
                   
               
               
                 IPI00153986.2 
                 K.GT*SR{circumflex over ( )}PGT*PSAEAASTSSTLR{circumflex over ( )}.A 
                 67 
                 Gtf2f1 
                 1 
               
               
                   
               
               
                 IPI00153986.2 
                 K.GTS*R{circumflex over ( )}PGT*PSAEAASTSSTLR{circumflex over ( )}.A 
                 68 
                 Gtf2f1 
                 1 
               
               
                   
               
               
                 IPI00929786.1 
                 R.TASIS*SSPS*EGTPAVGSYGCT*PQSLPK@.F 
                 69 
                 Larp1 
                 1 
               
               
                   
               
               
                 IPI00929786.1 
                 R.TASISS*SPSEGT*PAVGSYGCT*PQS*LPK@.F 
                 70 
                 Larp1 
                 1 
               
               
                   
               
               
                 IPI00130920.1 
                 R.RSES*PFECK.N 
                 71 
                 Mtap1b 
                 1 
               
               
                   
               
               
                 IPI00336973.2 
                 K.GLNLDGTPALSTLGGFS*PASK@PSS*PR{circumflex over ( )}.E 
                 72 
                 Ccnl1 
                 1 
               
               
                   
               
               
                 IPI00336973.2 
                 K.GLNLDGTPALSTLGGFSPAS*KPS*SPR.E 
                 73 
                 Ccnl1 
                 1 
               
               
                   
               
               
                 IPI00336973.2 
                 K.GLNLDGT*PALSTLGGFSPAS*K@PS*SPR{circumflex over ( )}.E 
                 74 
                 Ccnl1 
                 1 
               
               
                   
               
               
                 IPI00336973.2 
                 K.GLNLDGTPALSTLGGFSPAS*K@PS*SPR{circumflex over ( )}.E 
                 75 
                 Ccnl1 
                 1 
               
               
                   
               
               
                 IPI00379844.4 
                 R.TAS*EGDGGAAGGAGTAGGR{circumflex over ( )}PMSVAGS*PLS*PGPVR{circumflex over ( )}.A 
                 76 
                 Irs2 
                 1 
               
               
                   
               
               
                 IPI00336973.2 
                 K.GLNLDGTPALSTLGGFSPAS*KPSS*PR.E 
                 77 
                 Ccnl1 
                 1 
               
               
                   
               
               
                 IPI00336973.2 
                 K.GLNLDGT*PALSTLGGFSPAS*KPSS*PR.E 
                 78 
                 Ccnl1 
                 1 
               
               
                   
               
               
                 IPI00656285.2 
                 R.SLVS*PIPSPT*GTISVPNSCPAS*PR{circumflex over ( )}.G 
                 79 
                 Foxk1 
                 1 
               
               
                   
               
               
                 IPI00656285.2 
                 R.SLVS*PIPS*PTGTISVPNSCPAS*PR.G 
                 80 
                 Foxk1 
                 1 
               
               
                   
               
               
                 IPI00454104.1 
                 K.TTEAPCS*PGSQQPPS*PDELPANVK@.Q 
                 81 
                 Scrib 
                 1 
               
               
                   
               
               
                 IPI00753321.2 
                 K.S*VSETSEDK@K@DEES*DEEEEEEEEEEPLGATTR{circumflex over ( )}.S 
                 82 
                 Bod1l 
                 1 
               
               
                   
               
               
                 IPI00753321.2 
                 K.SVS*ETSEDK@K@DEES*DEEEEEEEEEEPLGATTR{circumflex over ( )}.S 
                 83 
                 Bod1l 
                 1 
               
               
                   
               
               
                 IPI00313307.3 
                 R.SYQNS*PSS*EDGIR{circumflex over ( )}PLPEYSTEK@.H 
                 84 
                 Med1 
                 1 
               
               
                   
               
               
                 IPI00225062.2 
                 R.GCS*PPK@S*PEK@PPQSTSS*ESCPPSPQPTK@.V 
                 85 
                 Srrm2 
                 1 
               
               
                   
               
               
                 IPI00318938.6 
                 R.NS*PVAK@TPPK@DLPAIPGVTS*PTSDEPPMQASQSQL 
                 86 
                 Eif4ebp1 
                 1 
               
               
                   
                 PSSPEDK@.R 
               
               
                   
               
               
                 IPI00130920.1 
                 R.SLMS*SPEDLTK@DFEELK@AEEIDVAK@.D 
                 87 
                 Mtap1b 
                 1 
               
               
                   
               
               
                 IPI00553798.2 
                 R.SS*EVVLS*GDDEDYQR{circumflex over ( )}.I 
                 88 
                 Ahnak 
                 1 
               
               
                   
               
               
                 IPI00129264.1 
                 R.ATSR{circumflex over ( )}PINLGPSS*PNTEIHWTPYR{circumflex over ( )}.A 
                 89 
                 Sorbs3 
                 1 
               
               
                   
               
               
                 IPI00129264.1 
                 R.ATSRPINLGPS*SPNTEIHWTPYR.A 
                 90 
                 Sorbs3 
                 1 
               
               
                   
               
               
                 IPI00123410.5 
                 R.TIS*AQDTLAYATALLNEK@.E 
                 91 
                 Usp24 
                 1 
               
               
                   
               
               
                 IPI00226441.2 
                 R.LHYT*PPLQS*PIT*DGDPLLGQS*PWR{circumflex over ( )}.S 
                 92 
                 Lin9 
                 1 
               
               
                   
               
               
                 IPI00309059.7 
                 R.ST*SPIIGS*PPVR{circumflex over ( )}.A 
                 93 
                 Patl1 
                 1 
               
               
                   
               
               
                 IPI00336713.1 
                 R.CS*PVPGLSSS*PSGSPLHGK@.L 
                 94 
                 Bcas3 
                 1 
               
               
                   
               
               
                 IPI00320905.7 
                 R.LGEQGPEPGPT*PPQTPT*PPS*TPPLAK.Q 
                 95 
                 Arhgap17 
                 1 
               
               
                   
               
               
                 IPI00309059.7 
                 R.R{circumflex over ( )}S*TS*PIIGS*PPVR{circumflex over ( )}.A 
                 96 
                 Patl1 
                 1 
               
               
                   
               
               
                 IPI00309059.7 
                 R.RSTS*PIIGS*PPVR.A 
                 97 
                 Patl1 
                 1 
               
               
                   
               
               
                 IPI00309059.7 
                 R.ST*S*PIIGS*PPVR{circumflex over ( )}.A 
                 98 
                 Patl1 
                 1 
               
               
                   
               
               
                 IPI00317599.3 
                 K.SQEDEEEISTS*PGVSEFVSDAFDTCSLNQEDLRK.E 
                 99 
                 Syap1 
                 1 
               
               
                   
               
               
                 IPI00317599.3 
                 K.SQEDEEEIST*SPGVSEFVSDAFDTCSLNQEDLRK.E 
                 100 
                 Syap1 
                 1 
               
               
                   
               
               
                 IPI00656285.2 
                 R.S*LVSPIPSPT*GTISVPNS*CPASPR{circumflex over ( )}.G 
                 101 
                 Foxk1 
                 1 
               
               
                   
               
               
                 IPI00676574.2 
                 R.RVS*TDLPEGQDVYTAACNSVIHR.C 
                 102 
                 Herc1 
                 1 
               
               
                   
               
               
                 IPI00458958.2 
                 K.DWDK@ES*EGEEPAGGR{circumflex over ( )}.A 
                 103 
                 Rrp15 
                 2 
               
               
                   
               
               
                 IPI00230719.8 
                 R.R{circumflex over ( )}DSS*DDWEIPDGQITVGQR{circumflex over ( )}.I 
                 104 
                 Braf 
                 2 
               
               
                   
               
               
                 IPI00318938.6 
                 R.VALGDGVQLPPGDYSTT*PGGTLFSTTPGGT*R.I 
                 105 
                 Eif4ebp1 
                 2 
               
               
                   
               
               
                 IPI00874995.2 
                 R.AS*DDLGEPDVFATAPFR.S 
                 106 
                 Aak1 
                 2 
               
               
                   
               
               
                 IPI00318938.6 
                 R.VALGDGVQLPPGDYSTT*PGGTLFSTTPGGT*R{circumflex over ( )}.I 
                 107 
                 Eif4ebp1 
                 2 
               
               
                   
               
               
                 IPI00318938.6 
                 R.VALGDGVQLPPGDYSTTPGGT*LFSTT*PGGTR.I 
                 108 
                 Eif4ebp1 
                 2 
               
               
                   
               
               
                 IPI00318938.6 
                 R.VALGDGVQLPPGDYSTTPGGT*LFSTT*PGGTR{circumflex over ( )}.I 
                 109 
                 Eif4ebp1 
                 2 
               
               
                   
               
               
                 IPI00323045.3 
                 R.S*MDVDLNQAHMEDTPK@.K 
                 110 
                 Melk 
                 2 
               
               
                   
               
               
                 IPI00623284.4 
                 K.IWDPTPSHT*PAGAAT*PGRGDT*PGHAT*PGHGGATSSA 
                 111 
                 Sf3b1 
                 2 
               
               
                   
                 R.K 
               
               
                   
               
               
                 IPI00125960.1 
                 R.TAS*GSS*VTSLEGTR.S 
                 112 
                 Ndrg1 
                 2 
               
               
                   
               
               
                 IPI00318938.6 
                 R.R{circumflex over ( )}VALGDGVQLPPGDYSTT*PGGTLFSTT*PGGTR{circumflex over ( )}.I 
                 113 
                 Eif4ebp1 
                 2 
               
               
                   
               
               
                 IPI00229571.1 
                 R.ISS*K@S*PGHMVILNQTK@.G 
                 114 
                 Sltm 
                 2 
               
               
                   
               
               
                 IPI00120095.2 
                 R.DFTK@PQDGDIIAPLIT*PLK@.W 
                 115 
                 Samhd1 
                 2 
               
               
                   
               
               
                 IPI00340860.5 
                 R.T*AS*EGSEAETPEAPK.Q 
                 116 
                 Larp7 
                 2 
               
               
                   
               
               
                 IPI00664670.4 
                 R.LGS*FGSITR{circumflex over ( )}.Q 
                 117 
                 Flnc 
                 2 
               
               
                   
               
               
                 IPI00654192.2 
                 R.S*LSFSEPQQPPPTVK@.S 
                 118 
                 Zfp395 
                 2 
               
               
                   
               
               
                 IPI00225062.2 
                 K.IHTTALTGQSPPLAS*GHQGEGDAPSVEPGATNIQQPSS* 
                 119 
                 Srrm2 
                 2 
               
               
                   
                 PAPSTK.Q 
               
               
                   
               
               
                 IPI00225062.2 
                 K.IHTTALTGQS*PPLASGHQGEGDAPSVEPGATNIQQPSS* 
                 120 
                 Srrm2 
                 2 
               
               
                   
                 PAPST*K@.Q 
               
               
                   
               
               
                 IPI00225062.2 
                 K.IHTTALTGQS*PPLASGHQGEGDAPSVEPGATNIQQPSS* 
                 121 
                 Srrm2 
                 2 
               
               
                   
                 PAPST*K.Q 
               
               
                   
               
               
                 IPI00339428.9 
                 R.MSSHTETS*SFLQTLTGR.L 
                 122 
                 Dock7 
                 2 
               
               
                   
               
               
                 IPI00225062.2 
                 R.DGSGT*PSRHSLS*GS*S*PGMKDTPQT*PSR.G 
                 123 
                 Srrm2 
                 2 
               
               
                   
               
               
                 IPI00668709.2 
                 R.DRS*SSAPNVHINTIEPVNIDDLIR.D 
                 124 
                 Braf 
                 2 
               
               
                   
               
               
                 IPI00135660.5 
                 R.RGNNS*AVGS*NADLT*IEEDEEEEPVALQQAQQVR.Y 
                 125 
                 Sdpr 
                 2 
               
               
                   
               
               
                 IPI00135660.5 
                 R.R{circumflex over ( )}GNNSAVGS*NADLT*IEEDEEEEPVALQQAQQVR{circumflex over ( )}.Y 
                 126 
                 Sdpr 
                 2 
               
               
                   
               
               
                 IPI00404545.2 
                 R.SLS*S*PTVTLSAPLEGAK@.D 
                 127 
                 Nedd4l 
                 2 
               
               
                   
               
               
                 IPI00121892.9 
                 R.R{circumflex over ( )}PPS*PDPNTK@.V 
                 128 
                 Spnb2 
                 2 
               
               
                   
               
               
                 IPI00322707.5 
                 K.AKQPVIGDQNSDS*DEMLAVLK.E 
                 129 
                 Atrx 
                 2 
               
               
                   
               
               
                 IPI00929786.1 
                 R.S*LPTTVPES*PNYR{circumflex over ( )}.N 
                 130 
                 Larp1 
                 3 
               
               
                   
               
               
                 IPI00125319.1 
                 R.TTS*FAESCK@PVQQPSAFGSMK@.V 
                 131 
                 Gsk3b 
                 3 
               
               
                   
               
               
                 Table 3. Categorization of mTOR targets identified in the rapamycin and Ku-0063794 screens. Class 1 includes downstream effectors of rapamycin-sensitive mTORC1. Class 2 includes downstream effectors of rapamycin-insensitive mTORC1 or mTORC2. Class 3 includes the proteins downstream of both mTORC1 and mTORC2. Name of exemplary genes and sequences of respective phosphopeptides are shown. 
               
               
                 *represents the site of phosphorylation (Ser, Thr and Tyr); 
               
               
                 {circumflex over ( )}and @ represent heavy Arg and Lys, respectively. 
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 4 
               
               
                   
               
               
                 Extracted Term 
                 IPI References 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
            
               
                 Rapamycin screen 
               
            
           
           
               
               
            
               
                 mTOR signaling pathway 
                 IPI00453603, IPI00318938, IPI00399440, IPI00268673, IPI00467843, IPI00221581, IPI00121335 
               
               
                 ErbB signaling pathway 
                 IPI00125319, IPI00453603, IPI00318938, IPI00113563, IPI00268673, IPI00121335 
               
               
                 Insulin signaling pathway 
                 IPI00125319, IPI00453603, IPI00116923, IPI00318938, IPI00268673, IPI00379844, IPI00121335 
               
               
                 Acute myeloid leukemia 
                 IPI00453603, IPI00318938, IPI00268673, IPI00121335 
               
               
                 Focal adhesion 
                 IPI00403938, IPI00125319, IPI00131138, IPI00113563, IPI00671847, IPI00121335 
               
               
                 Tight junction 
                 IPI00118143, IPI00380354, IPI00323349, IPI00845596, IPI00121335 
               
               
                 Pathways in cancer 
                 IPI00125319, IPI00121418, IPI00381495, IPI00113563, IPI00268673, IPI00380817, IPI00121335 
               
               
                 Prostate cancer 
                 IPI00125319, IPI00121418, IPI00268673, IPI00121335 
               
               
                 RNA degradation 
                 IPI00169888, IPI00309059, IPI00330066 
               
               
                 Glioma 
                 IPI00121418, IPI00268673, IPI00121335 
               
               
                 Adipocytokine signaling pathway 
                 IPI00268673, IPI00379844, IPI00121335 
               
               
                 VEGF signaling pathway 
                 IPI00111169, IPI00113563, IPI00121335 
               
               
                 Chronic myeloid leukemia 
                 IPI00121418, IPI00380817, IPI00121335 
               
            
           
           
               
            
               
                 Ku-0063794 Screen 
               
            
           
           
               
               
            
               
                 Erb6 signaling pathway 
                 IPI00453999, IPI00125319, IPI00453603, IPI00230719, IPI00318938, IPI00668709, IPI00131999 
               
               
                 mTOR signaling pathway 
                 IPI00453603, IPI00230719, IPI00318938, IPI00668709, IPI00221581 
               
               
                 Acute myeloid leukemia 
                 IPI00453603, IPI00230719, IPI00318938, IPI00668709, IPI00131999 
               
               
                 Cell cycle 
                 IPI00125319, IPI00124717, IPI00137864, IPI00131999 
               
               
                 Insulin signaling pathway 
                 IPI00125319, IPI00453603, IPI00230719, IPI00318938, IPI00668709 
               
               
                 Endometrial cancer 
                 IPI00125319, IPI00230719, IPI00668709, IPI00131999 
               
               
                 MAPK signaling pathway 
                 IPI00230719, IPI00117088, IPI00123474, IPI00668709, IPI00664670, IPI00131999 
               
               
                 RNA degradation 
                 IPI00309059, IPI00119442, IPI00330066 
               
               
                 Focal adhesion 
                 IPI00125319, IPI00230719, IPI00405227, IPI00668709, IPI00664670 
               
               
                 Colorectal cancer 
                 IPI00125319, IPI00230719, IPI00668709, IPI00131999 
               
               
                 TGF-beta signaling pathway 
                 IPI00453603, IPI00137864, IPI00131999 
               
               
                   
               
               
                 Table 4. Gene ontology analysis of mTOR targets identified in the rapamycin and Ku-0063794 screens. Pathways that were overrepresented among the rapamycin-sensitive and Ku-sensitive mTOR targets are shown. Also shown is the biological process that the rapamycin-sensitive and Ku-sensitive targets overrepresented. 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 Summary of the data. Two biological replicates were obtained for the rapamycin 
               
               
                 screen (each contained data from two technical replicates) and one SILAC experiment was 
               
               
                 performed for the Ku-0063794 screen. (L), light cells. (H), heavy cells. 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                 # of 
                 # of 
                 # of 
                   
                 Total 
               
               
                   
                 Bio- 
                 # of tech- 
                   
                   
                 phospho- 
                 phospho- 
                 unique 
                 Total 
                 phospho- 
               
               
                 Screen 
                 repli- 
                 replicate 
                 Cell 
                 Drug 
                 peptides 
                 proteins 
                 phospho- 
                 unique 
                 proteins 
               
               
                 ID 
                 cate 
                 combined 
                 line 
                 treatment 
                 (FDR %) 
                 (FDR %) 
                 sites 
                 sites 
                 (FDR %) 
               
               
                   
               
               
                 Rapa 
                 #1 
                 2 
                 TSC2-/- 
                 (L) DMSO 
                 14,635 
                 1,615 
                 4,484 
                   
                   
               
               
                   
                   
                   
                   
                 (H) rapa 
                 (0.25%) 
                 (1.0%) 
                   
                   
                   
               
               
                   
                 #2 
                 2 
                 TSC2-/- 
                 (L) rapa 
                 32,500 
                 1,866 
                 6,832 
                 11,271 
                 2,778 
               
               
                   
                   
                   
                   
                 (H) DMSO 
                 (0.28%) 
                 (0.97%) 
                   
                   
                 (1.7%) 
               
               
                 Ku 
                 #1 
                 1 
                 wt MEF 
                 (L) rapa 
                 34,642 
                 1,867 
                 6,220 
                   
                   
               
               
                   
                   
                   
                   
                 (H) rapa+Ku 
                 (0.28%) 
                 (0.97%) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 6 
               
               
                   
               
               
                 Gene 
                   
                   
                 SEQ 
                 Amino acid 
                 Median 
               
               
                 Name 
                 Description 
                 Modified Sequence 
                 ID NO 
                 position 
                 (treated/ctrl) 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
            
               
                 Rapa Screen (Proteins with downregulated phosphorylation) 
               
            
           
           
               
               
               
               
               
               
            
               
                 RPS6 
                 Ribosomal protein S6 
                 RLS*S*LRASTSK 
                 132 
                 S235, S236 
                 30.5 
               
               
                   
               
               
                 RPS6 
                 Ribosomal protein S6 
                 LSSLRAS*TS*KSES*S*QK 
                 133 
                 S240, S242, 
                 4.5 
               
               
                   
                   
                   
                   
                 S246, S247 
               
               
                   
               
               
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
                 S*LPVSVPVWAFK 
                 134 
                 S184 
                 2.2 
               
               
                   
               
               
                 Gsk3β 
                 Glycogen synthase kinase-3 
                 TTS*FAESCKPVQQPSAFGSMK 
                 135 
                 S9 
                 3.3 
               
               
                   
                 beta 
               
               
                   
               
               
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 RNS*PMAQT*PPCHLPNIPGVT 
                 136 
                 S65, T70 
                 39.1 
               
               
                   
                 factor 4E-binding protein 2 
                 SPGALIEDSK 
               
               
                   
               
               
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 TVAISDAAQLPDYCTT*PGGT 
                 137 
                 T37, T46 
                 2.3 
               
               
                   
                 factor 4E-binding protein 2 
                 LFSTT*PGGTRIIYDRK 
               
               
                   
               
               
                 Eif4b 
                 Eukaryotic translation initiation 
                 SRT*GS*ESSQTGASATSGR 
                 138 
                 T420, S422 
                 4.3 
               
               
                   
                 factor 4B 
               
               
                   
               
               
                 Eif4b 
                 Eukaryotic translation initiation 
                 TGS*ESS*QTGASATSGR 
                 139 
                 S422, S425 
                 4.6 
               
               
                   
                 factor 4B 
               
               
                   
               
               
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 NS*PVAKT*PPKDLPAIPGVTSP 
                 140 
                 S64, T69 
                 2.8 
               
               
                   
                 factor 4E-binding protein 1 
                 TSDEPPMQASQSQLPSSPEDK 
               
               
                   
               
               
                 Eif4g1 
                 Isoform 1 of Eukaryotic 
                 SFS*KEVEER 
                 141 
                 S1189 
                 2.8 
               
               
                   
                 translation initiation factor 4 
               
               
                   
                 gamma 1 
               
               
                   
               
               
                 Rps6kb1 
                 Isoform Alpha I of Ribosomal 
                 FIGS*PRT*PVS*PVKFSPGDFW 
                 142 
                 S441, T444, 
                 2.8 
               
               
                   
                 protein S6 kinase beta-1 
                 GR 
                   
                 S447 
               
               
                   
               
               
                 mTOR 
                 Isoform 1 of FKBP12- 
                 AGTTVPES*IHS*FIGDGLVKPE 
                 143 
                 S2478, 
                 3.6 
               
               
                   
                 rapamycin complex- 
                 ALNKK 
                   
                 S2481 
               
               
                   
                 associated protein 
               
               
                   
               
               
                 ULK1 
                 Serine/threonine-protein 
                 GGGASS*PAPVVFTVGS*PPSG 
                 144 
                 S747, S757, 
                 4.1 
               
               
                   
                 kinase ULK1 
                 AT*PPQSTR 
                   
                 T763 
               
               
                   
               
               
                 Grb10 
                 Isoform 3 of Growth factor 
                 MNILSS*QS*PLHPSTLNAVIHR 
                 145 
                 S421, S423 
                 27.3 
               
               
                   
                 receptor-bound protein 10 
               
               
                   
               
               
                 Grb10 
                 Isoform 3 of Growth factor 
                 T*ASLPAIPNPFPELTGAAPGS* 
                 146 
                 T76, S96, 
                 5.4 
               
               
                   
                 receptor-bound protein 10 
                 PPSVAPSS*LPPPPSQPPAK 
                   
                 S104 
               
               
                   
               
            
           
           
               
            
               
                 Ku Screen (Proteins with downregulated phosphorylation) 
               
            
           
           
               
               
               
               
               
               
            
               
                 Flnc 
                 Filamin-C 
                 LGS*FGSITR 
                 147 
                 S2234 
                 2.4 
               
               
                   
               
               
                 Gsk3β 
                 Glycogen synthase kinase-3 
                 TTS*FAESCKPVQQPSAFGSMK 
                 148 
                 S9 
                 2.2 
               
               
                   
                 beta 
               
               
                   
               
               
                 Ndrg1 
                 Protein NDRG1 
                 TAS*GSS*VTSLEGTR 
                 149 
                 S330, S333 
                 4.1 
               
               
                   
               
               
                 Braf 
                 B-Raf protein 
                 DRSSS*APNVHINTIEPVNIDDLIR 
                 150 
                 S312 
                 2.1 
               
               
                   
               
               
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
                 LNT*SDFQK 
                 151 
                 T247 
                 31.3 
               
               
                   
               
               
                 Eif4b 
                 Eukaryotic translation initiation 
                 TGS*ESSQTGASATSGR 
                 152 
                 S422 
                 2.2 
               
               
                   
                 factor 4B 
               
               
                   
               
               
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 VALGDGVQLPPGDYSTT*PGGT 
                 153 
                 T36, T45 
                 7.2 
               
               
                   
                 factor 4E-binding protein 1 
                 LFSTT*PGGTR 
               
               
                   
               
               
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 NS*PMAQTPPCHLPNIPGVTSP 
                 154 
                 S65 
                 6.8 
               
               
                   
                 factor 4E-bindg protein 2 
                 GALIEDSK 
               
               
                   
               
               
                 Table 6. Representative hits identified in the rapamycin and Ku-0063794 screens. Only protein targets with downregulated phosphorylation are shown. Median fold-changes of the identified phosphopeptides are reported. For the rapamycin screen, hits from the second biological replicate are shown. The control group is DMSO vehicle treated sample whereas the experiment group is the one treated with rapamycin. For the Ku-0063794 screen, the control group was treated with rapamycin whereas the experiment group was treated with a combination of rapamycin and Ku-0063794. An asterisk indicates the site of phosphorylation. Phosphorylation of Grb10 in MNILSS*QS*PLHPSTLNAVIHR (SEQ ID NO: 27) corresponds to S421/S423 in isoform 3 and S501/S503 in isoform 1, respectively. The site designation in the text corresponds to the sites in isoform 1 (mouse sequence). 
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 7 
               
               
                   
               
               
                   
                   
                   
                   
                   
                 Log2 
               
               
                   
                   
                 SEQ 
                   
                   
                 Area 
               
               
                   
                   
                 ID 
                 Gene 
                   
                 (H/L) 
               
               
                 Reference 
                 Ascore Seq 
                 NO: 
                 Name 
                 Annotation 
                 Ratio 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
            
               
                 Rapa replicate 1 (light cells were control and heavy cells were treated 
               
               
                 with rapamycin. L, light; H, heavy) 
               
            
           
           
               
               
               
               
               
               
            
               
                 IPI:IPI00136419.1 
                 LDGNPINLS*R 
                 155 
                 Epyc 
                 Epiphycan 
                 −7.993 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 LSS*LRAS*TSKSESSQK 
                 156 
                 rpS6 
                 29 kDa protein 
                 −7.693 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 RLS*S*LRASTSK 
                 157 
                 rpS6 
                 29 kDa protein 
                 −6.817 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 TPQAPTPANLVVGPR{circumflex over ( )}S*A 
                 158 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −6.606 
               
               
                   
                 HGT*APVNIAGS*R{circumflex over ( )} 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00111497.1 
                 VTEGSYSCLAHS*PLGVVA 
                 159 
                 Igdcc4 
                 Isoform 2 of Immunoglobulin 
                 −6.062 
               
               
                   
                 SQVAVVK 
                   
                   
                 superfamily DCC subclass member 4 
               
               
                   
               
               
                 IPI:IPI00874813.1 
                 MPAT*DTANLTAPWHPR 
                 160 
                 Ldhd 
                 22 kDa protein 
                 −5.745 
               
               
                   
               
               
                 IPI:IPI00126317.1 
                 NAS*TS*FQELEDKK 
                 161 
                 Dnajc2 
                 DnaJ homolog subfamily C member 2 
                 −5.522 
               
               
                   
               
               
                 IPI:IPI00187443.1 
                 WLKEAEEES*S*GGEEEDE 
                 162 
                 Eif5; 
                 Eukaryotic translation initiation 
                 −5.378 
               
               
                   
                 DENIEVVYSK 
                   
                 LOC100047658 
                 factor 5 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTT* 
                 163 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −5.301 
               
               
                   
                 PGGTLFS*TTPGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 S*AHGT*APVNIAGSRTPAG 
                 164 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −5.098 
               
               
                   
                 LAPTNLS*SSR 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00467423.3 
                 GYS*YDDSMESR 
                 165 
                 Gm13697 
                 Novel protein containing MIF4G and 
                 −5.093 
               
               
                   
                   
                   
                   
                 MA3 domains 
               
               
                   
               
               
                 IPI:IPI00467423.3 
                 GYS*YDDSMESR 
                 166 
                 Gm13697 
                 Novel protein containing MIF4G and 
                 −4.733 
               
               
                   
                   
                   
                   
                 MA3 domains 
               
               
                   
               
               
                 IPI:IPI00130920.1 
                 SDISPLT*PR 
                 167 
                 Mtap1b 
                 Microtubule-associated protein 1B 
                 −4.668 
               
               
                   
               
               
                 IPI:IPI00133685.1 
                 AATATRPPGPPPAPQPPS* 
                 168 
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
                 −4.667 
               
               
                   
                 PAPS*PPPRPALAR 
               
               
                   
               
               
                 IPI:IPI00154084.2 
                 GFGDS*FGR 
                 169 
                 Myef2 
                 Isoform 2 of Myelin expression factor 2 
                 −4.553 
               
               
                   
               
               
                 IPI:IPI00338745.4 
                 QADVADQQTTELPAENGET 
                 170 
                 Hmgn1; 
                 Non-histone chromosomal protein 
                 −4.546 
               
               
                   
                 ENQSPAS*EEEKEAKS*D 
                   
                 LOC100044391 
                 HMG-14 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 RNS*PMAQT*PPCHLPNIPG 
                 171 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 −4.531 
               
               
                   
                 VTSPGALIEDSK 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00154084.2 
                 GFGDS*FGR 
                 172 
                 Myef2 
                 Isoform 2 of Myelin expression factor 2 
                 −4.429 
               
               
                   
               
               
                 IPI:IPI00121519.1 
                 SYSESGLMGEPQPQGPPS* 
                 173 
                 Neurod1 
                 Neurogenic differentiation factor 1 
                 −4.393 
               
               
                   
                 WTDECLS*S*QDEEHEADKK 
               
               
                   
               
               
                 IPI:IPI00317794.5 
                 KEDS*DEDEDEEDEDDS*D 
                 174 
                 Ncl 
                 Nucleolin 
                 −4.345 
               
               
                   
                 EDEDDEEEDEFEPPIVK 
               
               
                   
               
               
                 IPI:IPI00399953.1 
                 VFTSDISDPVVASTSQAPG 
                 175 
                 Wnk1 
                 Serine/threonine-protein kinase WNK1 
                 −4.306 
               
               
                   
                 M#NLSHSASSLS*LQQAFS 
               
               
                   
                 ELK 
               
               
                   
               
               
                 IPI:IPI00263048.1 
                 VS*SETHQGPGTPESK 
                 176 
                 Numa1 
                 Nuclear mitotic apparatus protein 1 
                 −4.079 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 TPPSAPS*QSRM#T*SER 
                 177 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −4.002 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00263048.1 
                 VSS*ETHQGPGTPESK 
                 178 
                 Numa1 
                 Nuclear mitotic apparatus protein 1 
                 −3.674 
               
               
                   
               
               
                 IPI:IPI00664808.2 
                 SSSPT*NSLTQPIEMPTLSS 
                 179 
                 Kdm3b 
                 Isoform 2 of Lysine-specific 
                 −3.64 
               
               
                   
                 S*PTEER{circumflex over ( )}PTVGPGQQDNP 
                   
                   
                 demethylase 3B 
               
               
                   
                 LLK@ 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 RKETPS*PR 
                 180 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −3.569 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00453603.1 
                 TPVS*PVKFS*PGDFWGR 
                 181 
                 Rps6kb1 
                 Isoform Alpha I of Ribosomal protein 
                 −3.424 
               
               
                   
                   
                   
                   
                 S6 kinase beta-1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 R{circumflex over ( )}VALGDGVQLPPGDY*ST 
                 182 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.386 
               
               
                   
                 TPGGTLFSTTPGGT*R{circumflex over ( )} 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00330066.5 
                 DSQDTSAEQS*DHDDEVAS 
                 183 
                 Edc4 
                 Isoform 1 of Enhancer of mRNA- 
                 −3.347 
               
               
                   
                 LASASGGFGSK 
                   
                   
                 decapping protein 4 
               
               
                   
               
               
                 IPI:IPI00399953.1 
                 DAMNLS*GR 
                 184 
                 Wnk1 
                 Serine/threonine-protein kinase WNK1 
                 −3.343 
               
               
                   
               
               
                 IPI:IPI00127707.1 
                 LHQLAMQQSHFPMTHGNT 
                 185 
                 Pcbp2 
                 Isoform 1 of Poly(rC)-binding protein 2 
                 −3.277 
               
               
                   
                 GFSGIESSS*PEVK 
               
               
                   
               
               
                 IPI:IPI00458068.6 
                 SNS*LSEQLTVNSNPDTVK 
                 186 
                 Fkbp15 
                 Isoform B of FK506-binding protein 15 
                 −3.252 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 S*EGLSLER 
                 187 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 −3.127 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 S*EGLSLER{circumflex over ( )} 
                 188 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 −3.127 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00112101.1 
                 TTQSLQDFPVADS*EEEAE 
                 189 
                 Tfip11 
                 Tuftelin-interacting protein 11 
                 −3.096 
               
               
                   
                 EEFQKELSQWR 
               
               
                   
               
               
                 IPI:IPI00750472.3 
                 TESASLSQS*QVNGFFASH 
                 190 
                 Ptpn13 
                 Tyrosine-protein phosphatase non- 
                 −3.058 
               
               
                   
                 LGDR 
                   
                   
                 receptor type 13 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYS*TTP 
                 191 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.042 
               
               
                   
                 GGT*LFST*TPGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00317599.3 
                 SQEDEEEISTS*PGVSEFVS 
                 192 
                 Syap1 
                 Synapse-associated protein 1 
                 −3.022 
               
               
                   
                 DAFDTCS*LNQEDLRK 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 S*EGLSLER 
                 193 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 −3.012 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 T*PEMIIQKPKIS*M#QDVDL 
                 194 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 −2.987 
               
               
                   
                 S*LGSCK 
               
               
                   
               
               
                 IPI:IPI00751009.1 
                 TSEFPTPLFSGPLEPVACG 
                 195 
                 Srpk2 
                 serine/arginine-rich protein specific 
                 −2.951 
               
               
                   
                 SVISEGSPLTEQEESSPSH 
                   
                   
                 kinase 2 
               
               
                   
                 DR{circumflex over ( )}S*R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSSQS*PLHPSTLNAVI 
                 196 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 −2.946 
               
               
                   
                 HR 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 M#NILSS*QSPLHPSTLNAVI 
                 197 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 −2.944 
               
               
                   
                 HR 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 SSGLQTPECLS*REGS*PIP 
                 198 
                 Foxk1 
                 Forkhead box protein K1 
                 −2.896 
               
               
                   
                 HDPDLGSK 
               
               
                   
               
               
                 IPI:IPI00830829.1 
                 S*GEQITSS*PVS*PK 
                 199 
                 Hisppd1 
                 140 kDa protein 
                 −2.883 
               
               
                   
               
               
                 IPI:IPI00380722.1 
                 LAWVGDVFTTT*PTDPRPL 
                 200 
                 Bat2 
                 Large proline-rich protein BAT2 
                 −2.824 
               
               
                   
                 TS*PLR 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTS*RPGTPSAEAASTSSTLR 
                 201 
                 Gtf2f1 
                 General transcription factor IIF 
                 −2.802 
               
               
                   
                   
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00129276.2 
                 LES*LNIQR{circumflex over ( )} 
                 202 
                 Eif3a 
                 Eukaryotic translation initiation 
                 −2.792 
               
               
                   
                   
                   
                   
                 factor 3 subunit A 
               
               
                   
               
               
                 IPI:IPI00121277.1 
                 SAS*ESYTQSFQSR 
                 203 
                 Pi4k2a 
                 Phosphatidylinositol 4-kinase type 2- 
                 −2.789 
               
               
                   
                   
                   
                   
                 alpha 
               
               
                   
               
               
                 IPI:IPI00470003.3 
                 S*PTPKS*PPSR 
                 204 
                 Parva 
                 Alpha-parvin 
                 −2.746 
               
               
                   
               
               
                 IPI:IPI00308971.1 
                 AEALSSLHGDDQDS*EDEV 
                 205 
                 Igf2r 
                 Cation-independent mannose-6- 
                 −2.738 
               
               
                   
                 LTVPEVK 
                   
                   
                 phosphate receptor 
               
               
                   
               
               
                 IPI:IPI00121277.1 
                 SASESYT*QSFQSR 
                 206 
                 Pi4k2a 
                 Phosphatidylinositol 4-kinase type 2- 
                 −2.723 
               
               
                   
                   
                   
                   
                 alpha 
               
               
                   
               
               
                 IPI:IPI00130920.1 
                 VLS*PLR{circumflex over ( )}S*PPLLGSESPYE 
                 207 
                 Mtap1b 
                 Microtubule-associated protein 1B 
                 −2.715 
               
               
                   
                 DFLSADSK@ 
               
               
                   
               
               
                 IPI:IPI00129276.2 
                 LES*LNIQR 
                 208 
                 Eif3a 
                 Eukaryotic translation initiation 
                 −2.711 
               
               
                   
                   
                   
                   
                 factor 3 subunit A 
               
               
                   
               
               
                 IPI:IPI00111169.1 
                 CSVS*LSNVEAR 
                 209 
                 Pla2g4a 
                 Cytosolic phospholipase A2 
                 −2.664 
               
               
                   
               
               
                 IPI:IPI00458068.6 
                 HS*S*GNSM#LLPSMSVTM 
                 210 
                 Fkbp15 
                 Isoform B of FK506-binding protein 15 
                 −2.641 
               
               
                   
                 ETSM#IM#SNIQR 
               
               
                   
               
               
                 IPI:IPI00751009.1 
                 TVSASS*T*GDLPK@ 
                 211 
                 Srpk2 
                 serine/arginine-rich protein-specific 
                 −2.607 
               
               
                   
                   
                   
                   
                 kinase 2 
               
               
                   
               
               
                 IPI:IPI00222828.2 
                 S*SPNPFVGSPPK@ 
                 212 
                 Dab2 
                 Isoform p93 of Disabled homolog 2 
                 −2.599 
               
               
                   
               
               
                 IPI:IPI00111169.1 
                 CSVS*LSNVEAR 
                 213 
                 Pla2g4a 
                 Cytosolic phospholipase A2 
                 −2.579 
               
               
                   
               
               
                 IPI:IPI00120886.3 
                 SVGDGET*VEFDVVEGEK 
                 214 
                 Ybx1 
                 Nuclease-sensitive element-binding 
                 −2.553 
               
               
                   
                   
                   
                   
                 protein 1 
               
               
                   
               
               
                 IPI:IPI00751009.1 
                 TVS*ASS*TGDLPK@ 
                 215 
                 Srpk2 
                 serine/arginine-rich protein-specific 
                 −2.534 
               
               
                   
                   
                   
                   
                 kinase 2 
               
               
                   
               
               
                 IPI:IPI00133349.1 
                 DR{circumflex over ( )}S*PS*PLR{circumflex over ( )}GNVVPS*PL 
                 216 
                 Carhsp1 
                 Calcium-regulated heat stable protein 1 
                 −2.512 
               
               
                   
                 PTR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00469392.2 
                 GSGSVDET*LFALPAASEPV 
                 217 
                 Rtn4 
                 Isoform 1 of Reticulon-4 
                 −2.475 
               
               
                   
                 IPSSAEK 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 T*ASLPAIPNPFPELTGAAP 
                 218 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 −2.437 
               
               
                   
                 GS*PPSVAPSS*LPPPPSQP 
                   
                   
                 bound protein 10 
               
               
                   
                 PAK 
               
               
                   
               
               
                 IPI:IPI00751009.1 
                 TSEFPTPLFSGPLEPVACG 
                 219 
                 Srpk2 
                 serine/arginine-rich protein-specific 
                 −2.408 
               
               
                   
                 SVISEGSPLTEQEESSPSH 
                   
                   
                 kinase 2 
               
               
                   
                 DRS*R 
               
               
                   
               
               
                 IPI:IPI00761677.1 
                 S*RSPVDSPVPASMFAPEP 
                 220 
                 Gtpbp1 
                 GTP-binding protein 1 
                 −2.406 
               
               
                   
                 SS*PGAAR 
               
               
                   
               
               
                 IPI:IPI00468516.3 
                 TRT*VLS*LFDEDEDKVEDE 
                 221 
                 D6Wsu116e 
                 Isoform 1 of Protein FAM21 
                 −2.398 
               
               
                   
                 SSTCAPQDGR 
               
               
                   
               
               
                 IPI:IPI00396728.3 
                 R{circumflex over ( )}VSGS*ATPNSEAPR{circumflex over ( )} 
                 222 
                 Ddx51 
                 ATP-dependent RNA helicase DDX51 
                 −2.351 
               
               
                   
               
               
                 IPI:IPI00660767.2 
                 KRSDS*S*GGYTLSDVIQS* 
                 223 
                 Ibtk 
                 Isoform 2 of Inhibitor of Bruton 
                 −2.347 
               
               
                   
                 PPSAGLLK 
                   
                   
                 tyrosine kinase 
               
               
                   
               
               
                 IPI:IPI00226750.2 
                 TSST*CS*NES*LNAGGTPV 
                 224 
                 Tbc1d4 
                 140 kDa protein 
                 −2.275 
               
               
                   
                 TPR 
               
               
                   
               
               
                 IPI:IPI00113033.1 
                 RSPASSGSVAPQPS*SPPS 
                 225 
                 Ighmbp2 
                 DNA-binding protein SMUBP-2 
                 −2.241 
               
               
                   
                 *PAQAEPEPR 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THS*TSSS*IGSGESPFSR 
                 226 
                 Ndrg3 
                 Protein NDRG3 
                 −2.202 
               
               
                   
               
               
                 IPI:IPI00751009.1 
                 TSEFPTPLFSGPLEPVACG 
                 227 
                 Srpk2 
                 serine/arginine-rich protein-specific 
                 −2.187 
               
               
                   
                 SVISEGSPLTEQEESSPSH 
                   
                   
                 kinase 2 
               
               
                   
                 DRS*R 
               
               
                   
               
               
                 IPI:IPI00321647.2 
                 QNPEQS*ADEDAEKNEEDS 
                 228 
                 Eif3c 
                 Eukaryotic translation initiation 
                 −2.165 
               
               
                   
                 *EGS*S*DEDEDEDGVGNTT 
                   
                   
                 factor 3 subunit C 
               
               
                   
                 FLKK 
               
               
                   
               
               
                 IPI:IPI00453800.4 
                 HSSFADTGAAPSALSPESP 
                 229 
                 Zfp828 
                 Zinc finger protein 828 
                 −2.147 
               
               
                   
                 VLATS*PEPWGPS*LSASPE 
               
               
                   
                 SR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THS*TSSS*IGSGESPFSR{circumflex over ( )} 
                 230 
                 Ndrg3 
                 Protein NDRG3 
                 −2.124 
               
               
                   
               
               
                 IPI:IPI00377615.2 
                 RSS*RS*FSLDEPPLFIPDNI 
                 231 
                 Phf3 
                 PHD finger protein 3 
                 −2.124 
               
               
                   
                 ATVK 
               
               
                   
               
               
                 IPI:IPI00377615.2 
                 R{circumflex over ( )}SSR{circumflex over ( )}S*FS*LDEPPLFIPD 
                 232 
                 Phf3 
                 PHD finger protein 3 
                 −2.124 
               
               
                   
                 NIATVK@ 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 233 
                 Npm1 
                 Nucleophosmin 
                 −2.101 
               
               
                   
                 AES*EDEDEEDVKLLGM#S 
               
               
                   
                 GK 
               
               
                   
               
               
                 IPI:IPI00331075.4 
                 SLNFQEDDDT*S*RETFASD 
                 234 
                 Phax 
                 Phosphorylated adapter RNA export 
                 −2.101 
               
               
                   
                 TNEALASLDEAQEGPGETK 
                   
                   
                 protein 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THSTSS*S*IGSGESPFSR{circumflex over ( )} 
                 235 
                 Ndrg3 
                 Protein NDRG3 
                 −2.098 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THST*SSS*IGSGESPFSR 
                 236 
                 Ndrg3 
                 Protein NDRG3 
                 −2.098 
               
               
                   
               
               
                 IPI:IPI00669522.4 
                 SRS*DIDVNAAASAK 
                 237 
                 Clasp1 
                 Isoform 2 of CLIP-associating protein 1 
                 −2.073 
               
               
                   
               
               
                 IPI:IPI00117953.2 
                 S*TDSPVAGS*EDDLVAAAP 
                 238 
                 Bicc1; 
                 Isoform 1 of Protein bicaudal C 
                 −2.07 
               
               
                   
                 LLHSPEWSEER{circumflex over ( )} 
                   
                 4930533K18Rik 
                 homolog 1 
               
               
                   
               
               
                 IPI:IPI00137229.1 
                 GFQFVSSS*LPDICYR 
                 239 
                 Cnbp 
                 Isoform 2 of Cellular nucleic acid- 
                 −2.061 
               
               
                   
                   
                   
                   
                 binding protein 
               
               
                   
               
               
                 IPI:IPI00380309.3 
                 AMLDQLMGTS*R 
                 240 
                 Luc7l2 
                 Isoform 1 of Putative RNA-binding 
                 −2.046 
               
               
                   
                   
                   
                   
                 protein Luc7-like 2 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTSRPGT*PSAEAASTSSTLR 
                 241 
                 Gtf2f1 
                 General transcription factor IIF 
                 −2.035 
               
               
                   
                   
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00330262.5 
                 S*QDDAMVDYFFQR 
                 242 
                 Pum1 
                 Isoform 1 of Pumilio homolog 1 
                 −2.02 
               
               
                   
               
               
                 IPI:IPI00312128.3 
                 LDLDLTS*DSQPPVFK 
                 243 
                 Trim28 
                 Isoform 1 of Transcription intermediary 
                 −2.01 
               
               
                   
                   
                   
                   
                 factor 1-beta 
               
               
                   
               
               
                 IPI:IPI00667973.3 
                 IRQPS*IDLT*DDDQTSSVPH 
                 244 
                 Cep170 
                 Isoform 1 of Centrosomal protein 
                 −1.979 
               
               
                   
                 SAISDIMSSDQETYSCK 
                   
                   
                 of 170 kDa 
               
               
                   
               
               
                 IPI:IPI00468516.3 
                 TRT*VLS*LFDEDEDKVEDE 
                 245 
                 D6Wsu116e 
                 Isoform 1 of Protein FAM21 
                 −1.956 
               
               
                   
                 SSTCAPQDGR 
               
               
                   
               
               
                 IPI:IPI00136207.6 
                 YTPTSPSY*SPSSPEYTPAS 
                 246 
                 Polr2a 
                 DNA-directed RNA polymerase II 
                 −1.95 
               
               
                   
                 PK@ 
                   
                   
                 subunit RPB1 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 SLLPNSSQDELM#EVEKSE 
                 247 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.937 
               
               
                   
                 QPLSQVLPSLS*PEHK 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00222828.2 
                 S*SPNPFVGSPPK@ 
                 248 
                 Dab2 
                 Isoform p93 of Disabled homolog 2 
                 −1.915 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 RS*TS*PIIGS*PPVR 
                 249 
                 Patl1 
                 Protein PAT1 homolog 1 
                 −1.901 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 RST*S*PIIGS*PPVR 
                 250 
                 Patl1 
                 Protein PAT1 homolog 1 
                 −1.896 
               
               
                   
               
               
                 IPI:IPI00338745.4 
                 QADVADQQTTELPAENGET 
                 251 
                 Hmgn1; 
                 Non-histone chromosomal protein 
                 −1.895 
               
               
                   
                 ENQSPASEEEKEAKS*D 
                   
                 LOC100044391 
                 HMG-14 
               
               
                   
               
               
                 IPI:IPI00417158.1 
                 SQTPQLHFLDT*DDEISPTS 
                 252 
                 Smg6 
                 Telomerase-binding protein EST1A 
                 −1.895 
               
               
                   
                 WGDSR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00761759.1 
                 SSS*GSEHSTEGSVSLGDG 
                 253 
                 Larp4 
                 Putative uncharacterized protein 
                 −1.89 
               
               
                   
                 PLSR 
               
               
                   
               
               
                 IPI:IPI00314502.5 
                 VHGLPT*TSPSGVNMAELA 
                 254 
                 Tcfeb 
                 Transcription factor EB 
                 −1.887 
               
               
                   
                 QQVVK 
               
               
                   
               
               
                 IPI:IPI00117689.1 
                 ATEEPSGTGS*DELIK@SD 
                 255 
                 Ptrf 
                 Polymerase I and transcript release 
                 −1.875 
               
               
                   
                 QVNGVLVLSLLDK@ 
                   
                   
                 factor 
               
               
                   
               
               
                 IPI:IPI00462949.4 
                 AENIMAS*LER 
                 256 
                 Dock11 
                 Dedicator of cytokinesis protein 11 
                 −1.851 
               
               
                   
               
               
                 IPI:IPI00471475.1 
                 FDQLFDDES*DPFEVLK@ 
                 257 
                 Serbp1 
                 Isoform 1 of Plasminogen activator 
                 −1.845 
               
               
                   
                   
                   
                   
                 inhibitor 1 RNA-binding protein 
               
               
                   
               
               
                 IPI:IPI00471475.1 
                 FDQLFDDES*DPFEVLK 
                 258 
                 Serbp1 
                 Isoform 1 of Plasminogen activator 
                 −1.845 
               
               
                   
                   
                   
                   
                 inhibitor 1 RNA-binding protein 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 RS*TS*PIIGS*PPVR 
                 259 
                 Patl1 
                 Protein PAT1 homolog 1 
                 −1.837 
               
               
                   
               
               
                 IPI:IPI00331612.3 
                 K@PAQETEETSS*QES*AE 
                 260 
                 Hmga2 
                 High mobility group protein HMGI-C 
                 −1.834 
               
               
                   
                 ED 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 SLPT*TVPES*PNYR{circumflex over ( )} 
                 261 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 −1.823 
               
               
                   
               
               
                 IPI:IPI00112101.1 
                 TTQSLQDFPVADS*EEEAE 
                 262 
                 Tfip11 
                 Tuftelin-interacting protein 11 
                 −1.813 
               
               
                   
                 EEFQKELSQWR 
               
               
                   
               
               
                 IPI:IPI00133685.1 
                 SSDEENGPPSS*PDLDR 
                 263 
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
                 −1.779 
               
               
                   
               
               
                 IPI:IPI00761443.2 
                 SLS*ESYELSSDLQDK 
                 264 
                 Iqsec1 
                 IQ motif and Sec7 domain 1 isoform b 
                 −1.779 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKTPPKDLPAIPGVT 
                 265 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −1.776 
               
               
                   
                 *SPTSDEPPMQASQSQLPS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 SPEDK 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NSPVAKT*PPKDLPAIPGVT 
                 266 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −1.776 
               
               
                   
                 SPT*SDEPPMQASQSQLPS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 SPEDK 
               
               
                   
               
               
                 IPI:IPI00421179.1 
                 SFS*KEVEER 
                 267 
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation 
                 −1.77 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 1 
               
               
                   
               
               
                 IPI:IPI00379844.4 
                 TYS*LTTPAR 
                 268 
                 Irs2 
                 Insulin receptor substrate 2 
                 −1.769 
               
               
                   
               
               
                 IPI:IPI00379844.4 
                 TYS*LTTPAR 
                 269 
                 Irs2 
                 Insulin receptor substrate 2 
                 −1.769 
               
               
                   
               
               
                 IPI:IPI00127989.1 
                 FSEM#M#DHMGGDEDVDL 
                 270 
                 Ptges3; 
                 Prostaglandin E synthase 3 
                 −1.762 
               
               
                   
                 PEVDGADDDS*QDS*DDEK 
                   
                 Gm9769; 
               
               
                   
                 MPDLE 
                   
                 LOC100048119 
               
               
                   
               
               
                 IPI:IPI00127989.1 
                 FSEM#M#DHMGGDEDVDL 
                 271 
                 Ptges3; 
                 Prostaglandin E synthase 3 
                 −1.762 
               
               
                   
                 PEVDGADDDS*QDS*DDEK 
                   
                 Gm9769; 
               
               
                   
                 @MPDLE 
                   
                 LOC100048119 
               
               
                   
               
               
                 IPI:IPI00320208.3 
                 YGPSSVEDTTGSGAADAK 
                 272 
                 Eef1b2 
                 Elongation factor 1-beta 
                 −1.754 
               
               
                   
                 @DDDDIDLFGS*DDEEESE 
               
               
                   
                 EAK@ 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAK@T*PPK@DLPAI 
                 273 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −1.752 
               
               
                   
                 PGVTSPTSDEPPMQASQS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 QLPSSPEDK@ 
               
               
                   
               
               
                 IPI:IPI00317794.5 
                 KEDS*DEDEDEEDEDDS*D 
                 274 
                 Ncl 
                 Nucleolin 
                 −1.75 
               
               
                   
                 EDEDDEEEDEFEPPIVK 
               
               
                   
               
               
                 IPI:IPI00116331.1 
                 S*RTPSAS*HEEQQE 
                 275 
                 Sgta 
                 Isoform 1 of Small glutamine-rich 
                 −1.747 
               
               
                   
                   
                   
                   
                 tetratricopeptide repeat-containing 
               
               
                   
                   
                   
                   
                 protein alpha 
               
               
                   
               
               
                 IPI:IPI00116331.1 
                 S*R{circumflex over ( )}TPS*ASHEEQQE 
                 276 
                 Sgta 
                 Isoform 1 of Small glutamine-rich 
                 −1.747 
               
               
                   
                   
                   
                   
                 tetratricopeptide repeat-containing 
               
               
                   
                   
                   
                   
                 protein alpha 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 FGT*FGGLGS*K 
                 277 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 −1.745 
               
               
                   
               
               
                 IPI:IPI00130510.1 
                 LQDISELLAT*GVGLS*DSEV 
                 278 
                 Ppan 
                 Suppressor of SWI4 1 homolog 
                 −1.743 
               
               
                   
                 EPDGEHNTTELPQAVAGR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00330262.5 
                 S*QDDAMVDYFFQR 
                 279 
                 Pum1 
                 Isoform 1 of Pumilio homolog 1 
                 −1.734 
               
               
                   
               
               
                 IPI:IPI00459468.2 
                 LSESSALKQPAT*PTAAES* 
                 280 
                 Wmip1 
                 Isoform 1 of ATPase WRNIP1 
                 −1.728 
               
               
                   
                 S*EGEGEEGDDGGETESR 
               
               
                   
               
               
                 IPI:IPI00130573.1 
                 SLLSHEFQDET*DT*EEETL 
                 281 
                 Cpd 
                 Carboxypeptidase D 
                 −1.723 
               
               
                   
                 YSSK 
               
               
                   
               
               
                 IPI:IPI00468516.3 
                 TSALLFSS*DEEDQWNIADS 
                 282 
                 D6Wsu116e 
                 Isoform 1 of Protein FAM21 
                 −1.718 
               
               
                   
                 HTK 
               
               
                   
               
               
                 IPI:IPI00468516.3 
                 TSALLFSS*DEEDQWNIADS 
                 283 
                 D6Wsu116e 
                 Isoform 1 of Protein FAM21 
                 −1.718 
               
               
                   
                 HTK 
               
               
                   
               
               
                 IPI:IPI00109676.6 
                 SSGSSSSGLGTVSS*SPAS 
                 284 
                 Phf8 
                 Isoform 1 of PHD finger protein 8 
                 −1.715 
               
               
                   
                 QR 
               
               
                   
               
               
                 IPI:IPI00399953.1 
                 VFTSDISDPVVAST*SQAPG 
                 285 
                 Wnk1 
                 Serine/threonine-protein kinase WNK1 
                 −1.704 
               
               
                   
                 MNLSHSASSLSLQQAFSELK 
               
               
                   
               
               
                 IPI:IPI00399953.1 
                 VFTSDISDPVVASTSQAPG 
                 286 
                 Wnk1 
                 Serine/threonine-protein kinase WNK1 
                 −1.704 
               
               
                   
                 MNLSHSASS*LSLQQAFSE 
               
               
                   
                 LK@ 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 RSSS*ELS*PEVVEK 
                 287 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.702 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00116331.1 
                 S*RTPS*ASHEEQQE 
                 288 
                 Sgta 
                 Isoform 1 of Small glutamine-rich 
                 −1.694 
               
               
                   
                   
                   
                   
                 tetratricopeptide repeat-containing 
               
               
                   
                   
                   
                   
                 protein alpha 
               
               
                   
               
               
                 IPI:IPI00116331.1 
                 SRT*PS*ASHEEQQE 
                 289 
                 Sgta 
                 Isoform 1 of Small glutamine-rich 
                 −1.69 
               
               
                   
                   
                   
                   
                 tetratricopeptide repeat-containing 
               
               
                   
                   
                   
                   
                 protein alpha 
               
               
                   
               
               
                 IPI:IPI00116331.1 
                 S*R{circumflex over ( )}TPS*ASHEEQQE 
                 290 
                 Sgta 
                 Isoform 1 of Small glutamine-rich 
                 −1.69 
               
               
                   
                   
                   
                   
                 tetratricopeptide repeat-containing 
               
               
                   
                   
                   
                   
                 protein alpha 
               
               
                   
               
               
                 IPI:IPI00405752.3 
                 VLQESDVS*PSSSTTSLPIS* 
                 291 
                 C130092O11Rik 
                 Isoform 1 of Uncharacterized protein 
                 −1.689 
               
               
                   
                 PLTEEPLPFKDITR 
                   
                   
                 KIAA1680 
               
               
                   
               
               
                 IPI:IPI00380415.2 
                 ALS*LS*SADS*TDAKR 
                 292 
                 Bat2l 
                 Isoform 1 of Protein BAT2-like 
                 −1.687 
               
               
                   
               
               
                 IPI:IPI00130510.1 
                 LQDISELLATGVGLS*DS*EV 
                 293 
                 Ppan 
                 Suppressor of SWI4 1 homolog 
                 −1.68 
               
               
                   
                 EPDGEHNTTELPQAVAGR 
               
               
                   
               
               
                 IPI:IPI00229859.1 
                 AKPAAQS*EEETATS*PAAS 
                 294 
                 Eif3b 
                 Eif3b protein 
                 −1.677 
               
               
                   
                 *PTPQSAERS*PSQEPSAP 
               
               
                   
                 GK 
               
               
                   
               
               
                 IPI:IPI00224200.1 
                 RLS*S*TGGQTPR 
                 295 
                 Iws1 
                 Isoform 1 of Protein IWS1 homolog 
                 −1.663 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 R{circumflex over ( )}SSS*ELS*PEVVEK@ 
                 296 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.663 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00331612.3 
                 K@PAQETEETS*SQES*AE 
                 297 
                 Hmga2 
                 High mobility group protein HMGI-C 
                 −1.658 
               
               
                   
                 ED 
               
               
                   
               
               
                 IPI:IPI00229645.2 
                 K@GSS*GNAS*EVSVACLT 
                 298 
                 Cytsa 
                 Cytospin-A 
                 −1.657 
               
               
                   
                 ER{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00317794.5 
                 KEDS*DEDEDEEDEDDS*D 
                 299 
                 Ncl 
                 Nucleolin 
                 −1.637 
               
               
                   
                 EDEDDEEEDEFEPPIVK 
               
               
                   
               
               
                 IPI:IPI00663627.1 
                 GFLDGVYSFEYYPS*TPGK 
                 300 
                 Flnb 
                 Filamin-B 
                 −1.621 
               
               
                   
               
               
                 IPI:IPI00312128.3 
                 LDLDLTSDS*QPPVFK 
                 301 
                 Trim28 
                 Isoform 1 of Transcription intermediary 
                 −1.616 
               
               
                   
                   
                   
                   
                 factor 1-beta 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 HSGS*TSPY*PK@ 
                 302 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.603 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00312414.4 
                 TSTFCGT*PEFLAPEVLTET 
                 303 
                 Pkn2 
                 Isoform 1 of Serine/threonine-protein 
                 −1.603 
               
               
                   
                 SYTR{circumflex over ( )} 
                   
                   
                 kinase N2 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 S*NS*FSDER{circumflex over ( )}EFSAPST*PT 
                 304 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 −1.602 
               
               
                   
                 GT*LEFAGGDAK@ 
               
               
                   
               
               
                 IPI:IPI00126176.3 
                 VSLLGPVT*T*PEFQLVKTPL 
                 305 
                 Racgap1 
                 Rac GTPase-activating protein 1 
                 −1.597 
               
               
                   
                 SSSLSQR 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GSLSRSS*S*PVTELTAR 
                 306 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.593 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00399953.1 
                 VFTSDISDPVVASTSQAPG 
                 307 
                 Wnk1 
                 Serine/threonine-protein kinase WNK1 
                 −1.588 
               
               
                   
                 MNLSHS*ASSLSLQQAFSE 
               
               
                   
                 LK 
               
               
                   
               
               
                 IPI:IPI00226155.3 
                 VSALEEDMDDVES*S*EEEE 
                 308 
                 Prpf38a 
                 Isoform 1 of Pre-mRNA-splicing factor 
                 −1.585 
               
               
                   
                 EEDEKLER 
                   
                   
                 38A 
               
               
                   
               
               
                 IPI:IPI00226155.3 
                 VSALEEDMDDVES*S*EEEE 
                 309 
                 Prpf38a 
                 Isoform 1 of Pre-mRNA-splicing factor 
                 −1.585 
               
               
                   
                 EEDEK@LER{circumflex over ( )} 
                   
                   
                 38A 
               
               
                   
               
               
                 IPI:IPI00116331.1 
                 S*RTPS*ASHEEQQE 
                 310 
                 Sgta 
                 Isoform 1 of Small glutamine-rich 
                 −1.58 
               
               
                   
                   
                   
                   
                 tetratricopeptide repeat-containing 
               
               
                   
                   
                   
                   
                 protein alpha 
               
               
                   
               
               
                 IPI:IPI00116331.1 
                 S*R{circumflex over ( )}TPS*ASHEEQQE 
                 311 
                 Sgta 
                 Isoform 1 of Small glutamine-rich 
                 −1.58 
               
               
                   
                   
                   
                   
                 tetratricopeptide repeat-containing 
               
               
                   
                   
                   
                   
                 protein alpha 
               
               
                   
               
               
                 IPI:IPI00135660.5 
                 SLEETLHNVDLS*S*DDELP 
                 312 
                 Sdpr 
                 Serum deprivation-response protein 
                 −1.577 
               
               
                   
                 R{circumflex over ( )}DEEALEDSAEEK@ 
               
               
                   
               
               
                 IPI:IPI00323349.2 
                 HSSHDMLSHS*WEGNR 
                 313 
                 Tjp2 
                 Tight junction protein ZO-2 
                 −1.566 
               
               
                   
               
               
                 IPI:IPI00169500.3 
                 TESILDKEDKVPMAGVGGT 
                 314 
                 Atxn2l 
                 Isoform 1 of Ataxin-2-like protein 
                 −1.564 
               
               
                   
                 EGPEQLPAPCPSQTGS*PP 
               
               
                   
                 VGLIK 
               
               
                   
               
               
                 IPI:IPI00118143.1 
                 K@QTPPASPS*PQPIEDR{circumflex over ( )} 
                 315 
                 Cttn 
                 Src substrate cortactin 
                 −1.556 
               
               
                   
                 PPS*SPIYEDAAPFK@ 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 TVSLGAGAK@DELHIVEAE 
                 316 
                 Npm1 
                 Nucleophosmin 
                 −1.555 
               
               
                   
                 AM#NYEGS*PIK@VTLATLK@ 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 SLLPNSSQDELMEVEK@S 
                 317 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.55 
               
               
                   
                 EQPLSQVLPSLS*PEHK@ 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 SLLPNSSQDELMEVEKSEQ 
                 318 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.55 
               
               
                   
                 PLSQVLPSLS*PEHK 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00320267.1 
                 GDQVLNFS*DAEDLIDDSK 
                 319 
                 Mcrs1 
                 Microspherule protein 1 
                 −1.55 
               
               
                   
                 @LK@ 
               
               
                   
               
               
                 IPI:IPI00320267.1 
                 GDQVLNFS*DAEDLIDDSKLK 
                 320 
                 Mcrs1 
                 Microspherule protein 1 
                 −1.55 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 SNS*FSDER{circumflex over ( )}EFS*APS*TPT 
                 321 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 −1.548 
               
               
                   
                 *GTLEFAGGDAK@ 
               
               
                   
               
               
                 IPI:IPI00116331.1 
                 S*RTPS*ASHEEQQE 
                 322 
                 Sgta 
                 Isoform 1 of Small glutamine-rich 
                 −1.543 
               
               
                   
                   
                   
                   
                 tetratricopeptide repeat-containing 
               
               
                   
                   
                   
                   
                 protein alpha 
               
               
                   
               
               
                 IPI:IPI00222828.2 
                 SSPNPFVGS*PPK 
                 323 
                 Dab2 
                 Isoform p93 of Disabled homolog 2 
                 −1.531 
               
               
                   
               
               
                 IPI:IPI00317794.5 
                 KEDS*DEDEDEEDEDDS*D 
                 324 
                 Ncl 
                 Nucleolin 
                 −1.531 
               
               
                   
                 EDEDDEEEDEFEPPIVK 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 RSS*SELS*PEVVEK 
                 325 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.524 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 R{circumflex over ( )}SS*S*ELSPEVVEK@ 
                 326 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.524 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00116331.1 
                 S*RTPS*ASHEEQQE 
                 327 
                 Sgta 
                 Isoform 1 of Small glutamine-rich 
                 −1.52 
               
               
                   
                   
                   
                   
                 tetratricopeptide repeat-containing 
               
               
                   
                   
                   
                   
                 protein alpha 
               
               
                   
               
               
                 IPI:IPI00380415.2 
                 ALS*LS*S*ADSTDAKR 
                 328 
                 Bat2l 
                 Isoform 1 of Protein BAT2-like 
                 −1.519 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 RSSS*ELS*PEVVEK 
                 329 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.518 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 R{circumflex over ( )}SSS*ELS*PEVVEK@ 
                 330 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.518 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00399469.2 
                 VS*PPAS*PTLDVELGAGEA 
                 331 
                 Sh3rf1 
                 Isoform 2 of Putative E3 ubiquitin- 
                 −1.504 
               
               
                   
                 PLQGAVGPELPLGGSHGR 
                   
                   
                 protein ligase SH3RF1 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 R{circumflex over ( )}SS*SELS*PEVVEK@ 
                 332 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.501 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00137501.1 
                 TEMDKS*PFNS*PSPQDS*PR 
                 333 
                 Nfic 
                 Isoform 1 of Nuclear factor 1 C-type 
                 −1.498 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 RSTS*PIIGS*PPVR 
                 334 
                 Patl1 
                 Protein PAT1 homolog 1 
                 −1.498 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 RSS*SELS*PEVVEK 
                 335 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.497 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00116331.1 
                 S*R{circumflex over ( )}TPS*ASHEEQQE 
                 336 
                 Sgta 
                 Isoform 1 of Small glutamine-rich 
                 −1.493 
               
               
                   
                   
                   
                   
                 tetratricopeptide repeat-containing 
               
               
                   
                   
                   
                   
                 protein alpha 
               
               
                   
               
               
                 IPI:IPI00470095.1 
                 HGS*GADS*DYENTQSGDP 
                 337 
                 Git1 
                 ARF GTPase-activating protein GIT1 
                 −1.488 
               
               
                   
                 LLGLEGK@ 
               
               
                   
               
               
                 IPI:IPI00470095.1 
                 HGS*GADS*DYENTQSGDP 
                 338 
                 Git1 
                 ARF GTPase-activating protein GIT1 
                 −1.488 
               
               
                   
                 LLGLEGK 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 IHTTALTGQS*PPLASGHQG 
                 339 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.479 
               
               
                   
                 EGDAPSVEPGATNIQQPSS 
                   
                   
                 matrix protein 2 
               
               
                   
                 *PAPS*TK 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 TRLAS*ESANDDNEDS 
                 340 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 −1.456 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GSLSRSS*S*PVTELTAR 
                 341 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.454 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00320267.1 
                 GDQVLNFS*DAEDLIDDSK 
                 342 
                 Mcrs1 
                 Microspherule protein 1 
                 −1.454 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 RSSS*ELS*PEVVEK 
                 343 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.445 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00661508.3 
                 S*IDPDSIQSALLASGLGSK@ 
                 344 
                 Sbno1 
                 Isoform 2 of Protein strawberry notch 
                 −1.442 
               
               
                   
                   
                   
                   
                 homolog 1 
               
               
                   
               
               
                 IPI:IPI00661508.3 
                 S*IDPDSIQSALLASGLGSK 
                 345 
                 Sbno1 
                 Isoform 2 of Protein strawberry notch 
                 −1.442 
               
               
                   
                   
                   
                   
                 homolog 1 
               
               
                   
               
               
                 IPI:IPI00317794.5 
                 K@EDS*DEDEDEEDEDDS* 
                 346 
                 Ncl 
                 Nucleolin 
                 −1.441 
               
               
                   
                 DEDEDDEEEDEFEPPIVK@ 
               
               
                   
               
               
                 IPI:IPI00225267.6 
                 ATPTESPEKPPPPAVQRDE 
                 347 
                 2310022B05Rik 
                 Uncharacterized protein C1orf198 
                 −1.438 
               
               
                   
                 DDDALFS*EPALAQISSSNV 
                   
                   
                 homolog 
               
               
                   
                 LLK 
               
               
                   
               
               
                 IPI:IPI00122594.4 
                 EVS*VSS*VTEEPKLDSSQL 
                 348 
                 Ahctf1 
                 AT-hook-containing transcription 
                 −1.437 
               
               
                   
                 PLQTGLDVPATPR 
                   
                   
                 factor 1 
               
               
                   
               
               
                 IPI:IPI00129356.1 
                 SAFTPATATGS*S*PSPVLG 
                 349 
                 Itsn1 
                 lsoform 1 of Intersectin-1 
                 −1.43 
               
               
                   
                 QGEK@VEGLQAQALYPWR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGV 
                 350 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −1.412 
               
               
                   
                 TSPTSDEPPMQASQSQLPS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 S*PEDK 
               
               
                   
               
               
                 IPI:IPI00224200.1 
                 VVCDADDS*DSDVVSDK@ 
                 351 
                 Iws1 
                 Isoform 1 of Protein IWS1 homolog 
                 −1.403 
               
               
                   
               
               
                 IPI:IPI00321647.2 
                 QNPEQSADEDAEK@NEED 
                 352 
                 Eif3c 
                 Eukaryotic translation initiation 
                 −1.399 
               
               
                   
                 S*EGS*S*DEDEDEDGVGN 
                   
                   
                 factor 3 subunit C 
               
               
                   
                 TTFLK@ 
               
               
                   
               
               
                 IPI:IPI00664808.2 
                 VSESVADDS*SS*RDSFTQS 
                 353 
                 Kdm3b 
                 Isoform 2 of Lysine-specific 
                 −1.393 
               
               
                   
                 LESLTSGLCK 
                   
                   
                 demethylase 3B 
               
               
                   
               
               
                 IPI:IPI00122863.2 
                 RGQS*PQPDQGP 
                 354 
                 Rarg 
                 Isoform 2 of Retinoic acid receptor 
                 −1.387 
               
               
                   
                   
                   
                   
                 gamma 
               
               
                   
               
               
                 IPI:IPI00453853.2 
                 TPVASECTQTDGAEEVAGS 
                 355 
                 Bap1 
                 Ubiquitin carboxyl-terminal hydrolase 
                 −1.38 
               
               
                   
                 CPQTTTHS*PPSK@ 
                   
                   
                 BAP1 
               
               
                   
               
               
                 IPI:IPI00132028.1 
                 K@GS*DDDGGDS*PVQDID 
                 356 
                 Sap30 
                 Histone deacetylase complex subunit 
                 −1.376 
               
               
                   
                 TPEVDLYQLQVNTLR{circumflex over ( )} 
                   
                   
                 SAP30 
               
               
                   
               
               
                 IPI:IPI00132028.1 
                 KGS*DDDGGDS*PVQDIDT 
                 357 
                 Sap30 
                 Histone deacetylase complex subunit 
                 −1.376 
               
               
                   
                 PEVDLYQLQVNTLR 
                   
                   
                 SAP30 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGV 
                 358 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −1.374 
               
               
                   
                 TSPTSDEPPMQASQSQLPS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 S*PEDK 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 TRLAS*ESANDDNEDS 
                 359 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 −1.358 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTS*RPGT*PSAEAASTSST 
                 360 
                 Gtf2f1 
                 General transcription factor IIF 
                 −1.348 
               
               
                   
                 LR 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00226149.6 
                 GSASES*PSASVAEATTTD 
                 361 
                 Rsl1d1 
                 Putative uncharacterized protein 
                 −1.342 
               
               
                   
                 VQVTPTALLQLDR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00226149.6 
                 GS*ASESPSASVAEATTTD 
                 362 
                 Rsl1d1 
                 Putative uncharacterized protein 
                 −1.342 
               
               
                   
                 VQVTPTALLQLDR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00313307.3 
                 SYQNSPS*S*EDGIRPLPEY 
                 363 
                 Med1 
                 Isoform 4 of Mediator of RNA 
                 −1.337 
               
               
                   
                 STEK 
                   
                   
                 polymerase II transcription subunit 1 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 S*LVS*PIPSPTGTISVPNSC 
                 364 
                 Foxk1 
                 Forkhead box protein K1 
                 −1.327 
               
               
                   
                 PAS*PR 
               
               
                   
               
               
                 IPI:IPI00320208.3 
                 YGPSSVEDTTGSGAADAK 
                 365 
                 Eef1b2 
                 Elongation factor 1-beta 
                 −1.324 
               
               
                   
                 @DDDDIDLFGSDDEEES*E 
               
               
                   
                 EAK@ 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGV 
                 366 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −1.322 
               
               
                   
                 TSPTSDEPPMQASQSQLPS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 S*PEDK 
               
               
                   
               
               
                 IPI:IPI00136572.4 
                 SSTHASVS*PASEPSR 
                 367 
                 Zc3hav1 
                 Isoform 1 of Zinc finger CCCH-type 
                 −1.318 
               
               
                   
                   
                   
                   
                 antiviral protein 1 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 TRLAS*ES*ANDDNEDS 
                 368 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 −1.315 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 TR{circumflex over ( )}LAS*ES*ANDDNEDS 
                 369 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 −1.315 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00226149.6 
                 GS*ASESPSASVAEATTTD 
                 370 
                 Rsl1d1 
                 Putative uncharacterized protein 
                 −1.314 
               
               
                   
                 VQVTPTALLQLDR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00169500.3 
                 R{circumflex over ( )}SPGGT*SPPNGGLPGPL 
                 371 
                 Atxn2l 
                 Isoform 1 of Ataxin-2-like protein 
                 −1.308 
               
               
                   
                 TAT*AAPPGPPAAVSPCLG 
               
               
                   
                 PAAAAGSGLR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00467362.6 
                 S*ESLIDASEDS*QLEAAIR 
                 372 
                 Ubxn7 
                 UBX domain-containing protein 7 
                 −1.307 
               
               
                   
               
               
                 IPI:IPI00124753.3 
                 RNTFIGTPY*WMAPEVIACD 
                 373 
                 Mink1 
                 misshapen-like kinase 1 isoform 2 
                 −1.302 
               
               
                   
                 ENPDATYDYR 
               
               
                   
               
               
                 IPI:IPI00110247.7 
                 SLSQS*FENLLDEPAYGLIQ 
                 374 
                 Tbc1d15 
                 TBC1 domain family member 15 
                 −1.301 
               
               
                   
                 K@ 
               
               
                   
               
               
                 IPI:IPI00276222.1 
                 KLDDQS*EDEALELEGPLIM 
                 375 
                 Fermt2 
                 Fermitin family homolog 2 
                 −1.293 
               
               
                   
                 PGSGSIYSS*PGLYSK 
               
               
                   
               
               
                 IPI:IPI00460668.2 
                 EVDYSDS*LTEK@ 
                 376 
                 Smarca4 
                 Putative uncharacterized protein 
                 −1.293 
               
               
                   
               
               
                 IPI:IPI00380736.1 
                 STTPT*PSVITR 
                 377 
                 Zfp516 
                 Zinc finger protein 516 
                 −1.259 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTS*R{circumflex over ( )}PGT*PSAEAASTSS 
                 378 
                 Gtf2f1 
                 General transcription factor IIF 
                 −1.251 
               
               
                   
                 TLR{circumflex over ( )} 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00230486.3 
                 LSSKLS*AVS*LR 
                 379 
                 Snx17 
                 Sorting nexin-17 
                 −1.24 
               
               
                   
               
               
                 IPI:IPI00116331.1 
                 SR{circumflex over ( )}T*PSAS*HEEQQE 
                 380 
                 Sgta 
                 Isoform 1 of Small glutamine-rich 
                 −1.239 
               
               
                   
                   
                   
                   
                 tetratricopeptide repeat-containing 
               
               
                   
                   
                   
                   
                 protein alpha 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGV 
                 381 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −1.238 
               
               
                   
                 TSPTSDEPPMQASQSQLPS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 SPEDK 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGV 
                 382 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −1.238 
               
               
                   
                 TSPTSDEPPMQASQSQLPS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 SPEDK 
               
               
                   
               
               
                 IPI:IPI00749954.8 
                 LR{circumflex over ( )}TDNAS*DAS*ESS*DAE 
                 383 
                 Jmjd1c 
                 jumonji domain containing 1C 
                 −1.235 
               
               
                   
                 SSSK@ 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 SVSSPR{circumflex over ( )}T*K@ 
                 384 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.234 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THS*TSSSIGSGESPFSRA 
                 385 
                 Ndrg3 
                 Protein NDRG3 
                 −1.23 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THST*SSSIGSGESPFSR 
                 386 
                 Ndrg3 
                 Protein NDRG3 
                 −1.23 
               
               
                   
               
               
                 IPI:IPI00113377.1 
                 K@EESEES*EDDMGFGLFD 
                 387 
                 Rplp1 
                 60S acidic ribosomal protein P1 
                 −1.229 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 GGVT*GSPEAS*IS*GSK@G 
                 388 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 −1.228 
               
               
                   
                 DLK@ 
               
               
                   
               
               
                 IPI:IPI00330240.7 
                 S*QDAESYQNVVELK@ 
                 389 
                 Peg3 
                 Isoform 1 of Paternally-expressed gene 
                 −1.221 
               
               
                   
                   
                   
                   
                 3 protein 
               
               
                   
               
               
                 IPI:IPI00122845.1 
                 LGS*QEPER{circumflex over ( )} 
                 390 
                   
                   
                 −1.219 
               
               
                   
               
               
                 IPI:IPI00224200.1 
                 VVCDADDS*DSDVVSDK@ 
                 391 
                 Iws1 
                 Isoform 1 of Protein IWS1 homolog 
                 −1.219 
               
               
                   
               
               
                 IPI:IPI00465879.2 
                 LCS*SSSSDTSPR{circumflex over ( )} 
                 392 
                 Zc3hc1 
                 Isoform 1 of Nuclear-interacting 
                 −1.207 
               
               
                   
                   
                   
                   
                 partner of ALK 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 TR{circumflex over ( )}LAS*ES*ANDDNEDS 
                 393 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 −1.206 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 TRLAS*ES*ANDDNEDS 
                 394 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 −1.206 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00322095.4 
                 IDEPNT*PYHNMIGDDEDAY 
                 395 
                 Ppp1r2 
                 Putative uncharacterized protein 
                 −1.204 
               
               
                   
                 S*DSEGNEVMTPDILAK 
               
               
                   
               
               
                 IPI:IPI00322095.4 
                 IDEPNTPY*HNMIGDDEDAY 
                 396 
                 Ppp1r2 
                 Putative uncharacterized protein 
                 −1.204 
               
               
                   
                 S*DSEGNEVMTPDILAK 
               
               
                   
               
               
                 IPI:IPI00387384.3 
                 LLCQEETPEAT*EDERDEER 
                 397 
                 Mett10d 
                 Isoform 1 of Putative methyltransferase 
                 −1.202 
               
               
                   
                   
                   
                   
                 METT10D 
               
               
                   
               
               
                 IPI:IPI00330246.2 
                 WAAHGTS*PEDFSLTLGAR{circumflex over ( )} 
                 398 
                 Phldb1 
                 Isoform 2 of Pleckstrin homology-like 
                 −1.202 
               
               
                   
                   
                   
                   
                 domain family B member 1 
               
               
                   
               
               
                 IPI:IPI00330246.2 
                 WAAHGTS*PEDFSLTLGAR 
                 399 
                 Phldb1 
                 Isoform 2 of Pleckstrin homology-like 
                 −1.202 
               
               
                   
                   
                   
                   
                 domain family B member 1 
               
               
                   
               
               
                 IPI:IPI00678133.3 
                 SSHQDATDPEALWGVHQT 
                 400 
                 Inf2 
                 Isoform 1 of Inverted formin-2 
                 −1.199 
               
               
                   
                 EADS*T*S*EGPEDEAQR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00465879.2 
                 LCS*SSSSDTSPR{circumflex over ( )} 
                 401 
                 Zc3hc1 
                 Isoform 1 of Nuclear-interacting 
                 −1.189 
               
               
                   
                   
                   
                   
                 partner of ALK 
               
               
                   
               
               
                 IPI:IPI00313513.6 
                 S*VDIFGSTPFQPFSVSASK 
                 402 
                 Bmp2k 
                 Isoform 1 of BMP-2-inducible protein 
                 −1.18 
               
               
                   
                   
                   
                   
                 kinase 
               
               
                   
               
               
                 IPI:IPI00465879.2 
                 LCS*SSSSDTSPR 
                 403 
                 Zc3hc1 
                 Isoform 1 of Nuclear-interacting 
                 −1.172 
               
               
                   
                   
                   
                   
                 partner of ALK 
               
               
                   
               
               
                 IPI:IPI00465879.2 
                 LCS*SSSSDTSPR 
                 404 
                 Zc3hc1 
                 Isoform 1 of Nuclear-interacting 
                 −1.171 
               
               
                   
                   
                   
                   
                 partner of ALK 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 EFSAPST*PT*GTLEFAGGD 
                 405 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 −1.169 
               
               
                   
                 AK@ 
               
               
                   
               
               
                 IPI:IPI00317794.5 
                 K@EDS*DEDEDEEDEDDS* 
                 406 
                 Ncl 
                 Nucleolin 
                 −1.167 
               
               
                   
                 DEDEDDEEEDEFEPPIVK@ 
               
               
                   
               
               
                 IPI:IPI00465879.2 
                 LCS*SSSSDTSPR{circumflex over ( )} 
                 407 
                 Zc3hc1 
                 Isoform 1 of Nuclear-interacting 
                 −1.163 
               
               
                   
                   
                   
                   
                 partner of ALK 
               
               
                   
               
               
                 IPI:IPI00465879.2 
                 LCS*SSSSDTSPR 
                 408 
                 Zc3hc1 
                 Isoform 1 of Nuclear-interacting 
                 −1.163 
               
               
                   
                   
                   
                   
                 partner of ALK 
               
               
                   
               
               
                 IPI:IPI00229739.4 
                 LVVSS*PT*SPKGK 
                 409 
                 Plekhm1 
                 Pleckstrin homology domain-containing 
                 −1.159 
               
               
                   
                   
                   
                   
                 family M member 1 
               
               
                   
               
               
                 IPI:IPI00465879.2 
                 LCS*SSSSDTSPR 
                 410 
                 Zc3hc1 
                 Isoform 1 of Nuclear-interacting 
                 −1.156 
               
               
                   
                   
                   
                   
                 partner of ALK 
               
               
                   
               
               
                 IPI:IPI00465879.2 
                 LCS*SSSSDTSPR{circumflex over ( )} 
                 411 
                 Zc3hc1 
                 Isoform 1 of Nuclear-interacting 
                 −1.155 
               
               
                   
                   
                   
                   
                 partner of ALK 
               
               
                   
               
               
                 IPI:IPI00225616.3 
                 DGAGS*PLR{circumflex over ( )}T*SPPSTPSS 
                 412 
                 Dennd2a 
                 DENN domain-containing protein 2A 
                 −1.15 
               
               
                   
                 PDDTFFNLGDLQNGR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00720110.2 
                 VLTANSNPSS*PSAAK 
                 413 
                 1600027N09Rik 
                 RIKEN cDNA 1600027N09 gene 
                 −1.148 
               
               
                   
               
               
                 IPI:IPI00465879.2 
                 LCS*SSSSDTSPR 
                 414 
                 Zc3hc1 
                 Isoform 1 of Nuclear-interacting 
                 −1.143 
               
               
                   
                   
                   
                   
                 partner of ALK 
               
               
                   
               
               
                 IPI:IPI00461396.6 
                 STRHS*PSALQDVFVELLS* 
                 415 
                 Baz1a 
                 bromodomain adjacent to zinc finger 
                 −1.134 
               
               
                   
                 PHSK 
                   
                   
                 domain 1A 
               
               
                   
               
               
                 IPI:IPI00222828.2 
                 SSPNPFVGS*PPK@ 
                 416 
                 Dab2 
                 Isoform p93 of Disabled homolog 2 
                 −1.134 
               
               
                   
               
               
                 IPI:IPI00222828.2 
                 SSPNPFVGS*PPK 
                 417 
                 Dab2 
                 Isoform p93 of Disabled homolog 2 
                 −1.134 
               
               
                   
               
               
                 IPI:IPI00222828.2 
                 SSPNPFVGS*PPK 
                 418 
                 Dab2 
                 Isoform p93 of Disabled homolog 2 
                 −1.134 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GCS*PPKS*PEKPPQSTSS* 
                 419 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.133 
               
               
                   
                 ESCPPSPQPTK 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 GGVTGS*PEAS*IS*GSK@G 
                 420 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 −1.132 
               
               
                   
                 DLK@ 
               
               
                   
               
               
                 IPI:IPI00318671.2 
                 DK@PVYDELFYTLS*PINGK@ 
                 421 
                 Ehd4 
                 EH-domain containing 4-KJR 
                 −1.131 
               
               
                   
                   
                   
                   
                 (Fragment) 
               
               
                   
               
               
                 IPI:IPI00129388.1 
                 HDHAVSLLTAASPT*ISLL 
                 422 
                 Scrib 
                 Isoform 3 of Protein LAP4 
                 −1.13 
               
               
                   
                 LER 
               
               
                   
               
               
                 IPI:IPI00336973.2 
                 GLNLDGTPALSTLGGFS*PA 
                 423 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 −1.124 
               
               
                   
                 SKPSS*PR 
               
               
                   
               
               
                 IPI:IPI00336973.2 
                 GLNLDGTPALSTLGGFS*PA 
                 424 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 −1.124 
               
               
                   
                 SK@PSS*PR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00317401.6 
                 METVSNASSSSNPSS*PGR{circumflex over ( )} 
                 425 
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion 
                 −1.12 
               
               
                   
                   
                   
                   
                 protein PDS5 homolog B 
               
               
                   
               
               
                 IPI:IPI00317401.6 
                 METVSNASSSSNPSS*PGR 
                 426 
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion 
                 −1.12 
               
               
                   
                   
                   
                   
                 protein PDS5 homolog B 
               
               
                   
               
               
                 IPI:IPI00471475.1 
                 HSGSDR{circumflex over ( )}S*SFSHYSGLK@ 
                 427 
                 Serbp1 
                 Isoform 1 of Plasminogen activator 
                 −1.119 
               
               
                   
                   
                   
                   
                 inhibitor 1 RNA-binding protein 
               
               
                   
               
               
                 IPI:IPI00330240.7 
                 S*QDAESYQNVVELK@ 
                 428 
                 Peg3 
                 Isoform 1 of Paternally-expressed gene 
                 −1.108 
               
               
                   
                   
                   
                   
                 3 protein 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTS*RPGTPSAEAASTSSTLR 
                 429 
                 Gtf2f1 
                 General transcription factor IIF 
                 −1.102 
               
               
                   
                   
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00453656.2 
                 KVAPLS*SSLDTSLDFSK 
                 430 
                 Uvrag 
                 UV radiation resistance associated 
                 −1.098 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 SVS*ENS*LVAMDFSGQIGR 
                 431 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 −1.097 
               
               
                   
                   
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00135443.2 
                 KTS*FDQDS*DVDIFPSDFT 
                 432 
                 Top2b 
                 DNA topoisomerase 2-beta 
                 −1.092 
               
               
                   
                 SEPPALPR 
               
               
                   
               
               
                 IPI:IPI00331612.3 
                 KPAQETEETSS*QES*AEED 
                 433 
                 Hmga2 
                 High mobility group protein HMGI-C 
                 −1.078 
               
               
                   
               
               
                 IPI:IPI00331612.3 
                 K@PAQETEETSS*QES*AE 
                 434 
                 Hmga2 
                 High mobility group protein HMGI-C 
                 −1.078 
               
               
                   
                 ED 
               
               
                   
               
               
                 IPI:IPI00320208.3 
                 YGPSSVEDTTGSGAADAK 
                 435 
                 Eef1b2 
                 Elongation factor 1-beta 
                 −1.075 
               
               
                   
                 @DDDDIDLFGS*DDEEESE 
               
               
                   
                 EAK@ 
               
               
                   
               
               
                 IPI:IPI00321884.1 
                 ESLPLDLS*DDQSNSK 
                 436 
                 Nvl 
                 Nuclear valosin-containing protein-like 
                 −1.071 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 437 
                 Npm1 
                 Nucleophosmin 
                 −1.071 
               
               
                   
                 AES*EDEDEEDVK@LLGMS 
               
               
                   
                 GK@ 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 GGVTGS*PEAS*ISGS*K@G 
                 438 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 −1.067 
               
               
                   
                 DLK@ 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THST*SS*SIGSGESPFSR 
                 439 
                 Ndrg3 
                 Protein NDRG3 
                 −1.054 
               
               
                   
               
               
                 IPI:IPI00130920.1 
                 VLS*PLR{circumflex over ( )}SPPLLGSES*PYE 
                 440 
                 Mtap1b 
                 Microtubule-associated protein 1B 
                 −1.054 
               
               
                   
                 DFLSADSK@ 
               
               
                   
               
               
                 IPI:IPI00349069.4 
                 GPQQDS*DS*DDGEALGGN 
                 441 
                 B230208H17Rik 
                 Putative GTP-binding protein Parf 
                 −1.048 
               
               
                   
                 PMVAGFQDDVDIEDQTHGK 
               
               
                   
               
               
                 IPI:IPI00349069.4 
                 GPQQDS*DS*DDGEALGGN 
                 442 
                 B230208H17Rik 
                 Putative GTP-binding protein Parf 
                 −1.048 
               
               
                   
                 PMVAGFQDDVDIEDQTHG 
               
               
                   
                 K@ 
               
               
                   
               
               
                 IPI:IPI00408803.6 
                 GR{circumflex over ( )}ES*DEDT*EDAS*ETDL 
                 443 
                 Suds3 
                 Sin3 histone deacetylase corepressor 
                 −1.047 
               
               
                   
                 AK@ 
                   
                   
                 complex component SDS3 
               
               
                   
               
               
                 IPI:IPI00109311.3 
                 SASS*DTS*EELNS*QDSPK 
                 444 
                 Slc9a3r1 
                 Isoform 1 of Na(+)/H(+) exchange 
                 −1.047 
               
               
                   
                 @R{circumflex over ( )} 
                   
                   
                 regulatory cofactor NHE-RF1 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THSTSS*SIGSGESPFSR{circumflex over ( )} 
                 445 
                 Ndrg3 
                 Protein NDRG3 
                 −1.042 
               
               
                   
               
               
                 IPI:IPI00114560.5 
                 FRT*ITSSYYR 
                 446 
                 Rab1 
                 Ras-related protein Rab-1A 
                 −1.042 
               
               
                   
               
               
                 IPI:IPI00123410.5 
                 TIS*AQDTLAYATALLNEK 
                 447 
                 Usp24 
                 Isoform 1 of Ubiquitin carboxyl- 
                 −1.04 
               
               
                   
                   
                   
                   
                 terminal hydrolase 24 
               
               
                   
               
               
                 IPI:IPI00169477.1 
                 NT*PSQHSHSIQHS*PER{circumflex over ( )} 
                 448 
                 Bclaf1 
                 Isoform 2 of Bcl-2-associated 
                 −1.036 
               
               
                   
                   
                   
                   
                 transcription factor 1 
               
               
                   
               
               
                 IPI:IPI00317401.6 
                 AES*PETSAVESTQST*PQK 
                 449 
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion 
                 −1.036 
               
               
                   
                   
                   
                   
                 protein PDS5 homolog B 
               
               
                   
               
               
                 IPI:IPI00317401.6 
                 METVSNASSSSNPSS*PGR{circumflex over ( )} 
                 450 
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion 
                 −1.035 
               
               
                   
                   
                   
                   
                 protein PDS5 homolog B 
               
               
                   
               
               
                 IPI:IPI00317401.6 
                 METVSNASSSSNPSS*PGR 
                 451 
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion 
                 −1.035 
               
               
                   
                   
                   
                   
                 protein PDS5 homolog B 
               
               
                   
               
               
                 IPI:IPI00229702.1 
                 KDS*PPLVT*PPQS*PPSSQ 
                 452 
                 Smtnl2 
                 Smoothelin-like protein 2 
                 −1.03 
               
               
                   
                 PPAMTQAPR 
               
               
                   
               
               
                 IPI:IPI00107999.1 
                 SSPS*ILAVQR 
                 453 
                 Chd1 
                 Chromodomain-helicase-DNA-binding 
                 −1.019 
               
               
                   
                   
                   
                   
                 protein 1 
               
               
                   
               
               
                 IPI:IPI00107999.1 
                 SS*PSILAVQR{circumflex over ( )} 
                 454 
                 Chd1 
                 Chromodomain-helicase-DNA-binding 
                 −1.019 
               
               
                   
                   
                   
                   
                 protein 1 
               
               
                   
               
               
                 IPI:IPI00118120.1 
                 TSS*IADEGTYTLDSILR 
                 455 
                 Myo5a 
                 Myosin-Va 
                 −1.018 
               
               
                   
               
               
                 IPI:IPI00453848.5 
                 SAFK@LDS*DS*DEEDAQF 
                 456 
                 Atg2a 
                 Protein 
                 −1.014 
               
               
                   
                 FSMASGVPQTPAPEPSR{circumflex over ( )}R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 AS*YSGTSPSHSFISGEPDR{circumflex over ( )} 
                 457 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 −1.013 
               
               
                   
                   
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GCS*PPKS*PEKPPQSTSS* 
                 458 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.003 
               
               
                   
                 ESCPPSPQPTK 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00229613.3 
                 SSS*SASQSNHSCTSMPSS 
                 459 
                 Macf1 
                 Isoform 3 of Microtubule-actin cross- 
                 −1.003 
               
               
                   
                 PATPASGTK 
                   
                   
                 linking factor 1 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THS*TSSS*IGSGESPFSR{circumflex over ( )} 
                 460 
                 Ndrg3 
                 Protein NDRG3 
                 −1.002 
               
               
                   
               
               
                 IPI:IPI00121135.5 
                 R.S*KS*PPKS*PEEEGAVS* 
                 461 
                 Sfrs2 
                 Splicing factor 
                 −1 
               
               
                   
                 S. 
               
               
                   
               
               
                 IPI:IPI00126338.5 
                 R.SST*PLPTVS*SS*AENTR 
                 462 
                 Tmpo 
                 Isoform Alpha of Lamina-associated 
                 −1 
               
               
                   
                 {circumflex over ( )}.Q 
                   
                   
                 polypeptide 2 
               
               
                   
               
               
                 IPI:IPI00623249.4 
                 R.T*DSVIIADQT*PT* 
                 463 
                 Atf7 
                 Activating transcription factor 7 
                 −1 
               
               
                   
                 PTR{circumflex over ( )}.F 
               
            
           
           
               
            
               
                 Rapa replicate 2 (Note: heavy cells were control and light cells were 
               
               
                 treated with rapamycin. L, light; H, heavy.) 
               
            
           
           
               
               
               
               
               
               
            
               
                 IPI:IPI00330112.1 
                 VAPAGSAIS*NASGER{circumflex over ( )} 
                 464 
                 Mib1 
                 E3 ubiquitin-protein ligase MIB1 
                 9.6909 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 R{circumflex over ( )}LS*S*LR{circumflex over ( )}AS*TSK@ 
                 465 
                 rpS6 
                 29 kDa protein 
                 9.6182 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 R{circumflex over ( )}LS*S*LR{circumflex over ( )}AS*TSK@ 
                 466 
                 rpS6 
                 29 kDa protein 
                 9.6182 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 ELS*HSPPRENSFESSLEFK 
                 467 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 9.4619 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 R{circumflex over ( )}LS*S*LR{circumflex over ( )}AS*TSK@ 
                 468 
                 rpS6 
                 29 kDa protein 
                 9.4253 
               
               
                   
               
               
                 IPI:IPI00346155.4 
                 NFLS*MDS*LK@ 
                 469 
                 Gm13099 
                 Novel protein similar to preferentially 
                 9.2638 
               
               
                   
                   
                   
                   
                 expressed antigen in melanoma-like 
               
               
                   
                   
                   
                   
                 family 
               
               
                   
               
               
                 IPI:IPI00649156.4 
                 NLAITGGVTLS*VIASPVI 
                 470 
                 Rnf19b 
                 IBR domain containing 3 
                 9.1171 
               
               
                   
                 AAVSVGIGVPIMLAY*VY* 
               
               
                   
                 GVVPISLCR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 R{circumflex over ( )}LS*S*LR{circumflex over ( )}AS*TSK@ 
                 471 
                 rpS6 
                 29 kDa protein 
                 9.0561 
               
               
                   
               
               
                 IPI:IPI00133349.1 
                 TR{circumflex over ( )}TFS*ATVR{circumflex over ( )} 
                 472 
                 Carhsp1 
                 Calcium-regulated heat stable protein 1 
                 8.7001 
               
               
                   
               
               
                 IPI:IPI00133349.1 
                 TR{circumflex over ( )}TFS*ATVR{circumflex over ( )} 
                 473 
                 Carhsp1 
                 Calcium-regulated heat stable protein 1 
                 8.6779 
               
               
                   
               
               
                 IPI:IPI00133349.1 
                 TR{circumflex over ( )}TFS*ATVR{circumflex over ( )} 
                 474 
                 Carhsp1 
                 Calcium-regulated heat stable protein 1 
                 8.6519 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 R{circumflex over ( )}LS*S*LR{circumflex over ( )}AS*TSK@ 
                 475 
                 rpS6 
                 29 kDa protein 
                 8.6271 
               
               
                   
               
               
                 IPI:IPI00351206.5 
                 GLCSGPGAGEESPAAT*LP 
                 476 
                 Pgrmc2 
                 Membrane-associated progesterone 
                 8.5943 
               
               
                   
                 R{circumflex over ( )}M#K@ 
                   
                   
                 receptor component 2 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 LS*SLR{circumflex over ( )}AS*TSK@ 
                 477 
                 rpS6 
                 29 kDa protein 
                 7.5465 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 LSS*LR{circumflex over ( )}AS*TSK@ 
                 478 
                 rpS6 
                 29 kDa protein 
                 7.5465 
               
               
                   
               
               
                 IPI:IPI00131138.1 
                 AHVAPCFDAS*K@ 
                 479 
                   
                   
                 7.3937 
               
               
                   
               
               
                 IPI:IPI00125530.1 
                 WTNDYSMVLTGAAIY*HK@ 
                 480 
                 Ext1 
                 Exostosin-1 
                 7.3545 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 LSS*LR{circumflex over ( )}AS*TSK@ 
                 481 
                 rpS6 
                 29 kDa protein 
                 7.1711 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 LSS*LR{circumflex over ( )}AS*TSK@ 
                 482 
                 rpS6 
                 29 kDa protein 
                 7.1711 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 R{circumflex over ( )}LSS*LR{circumflex over ( )}AS*TSK@ 
                 483 
                 rpS6 
                 29 kDa protein 
                 7.0714 
               
               
                   
               
               
                 IPI:IPI00131138.1 
                 AHVAPCFDAS*K@ 
                 484 
                   
                   
                 7.0413 
               
               
                   
               
               
                 IPI:IPI00378564.4 
                 LVY*PEVK@ES*K@FK@ 
                 485 
                 Gm14085 
                 Novel protein similar to solute carrier 
                 6.9768 
               
               
                   
                   
                   
                   
                 family 28 (Sodium-coupled nucleoside 
               
               
                   
                   
                   
                   
                 transporter) member 2 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 R{circumflex over ( )}LSS*LR{circumflex over ( )}AS*TSK@ 
                 486 
                 rpS6 
                 29 kDa protein 
                 6.9459 
               
               
                   
               
               
                 IPI:IPI00133685.1 
                 AATATRPPGPPPAPQPPS* 
                 487 
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
                 6.9065 
               
               
                   
                 PAPS*PPPRPALAR 
               
               
                   
               
               
                 IPI:IPI00316922.1 
                 R{circumflex over ( )}LGAAM#T*FPR{circumflex over ( )}PPSR{circumflex over ( )} 
                 488 
                 Gm9757 
                 Putative uncharacterized protein 
                 6.6604 
               
               
                   
               
               
                 IPI:IPI00118875.4 
                 ATAPQTQHVS*PMR{circumflex over ( )} 
                 489 
                 Eef1d 
                 eukaryotic translation elongation 
                 6.5442 
               
               
                   
                   
                   
                   
                 factor 1 delta isoform a 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 R{circumflex over ( )}NS*PMAQT*PPCHLPNIP 
                 490 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 6.5094 
               
               
                   
                 GVTSPGALIEDSK@ 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 R{circumflex over ( )}NS*PMAQT*PPCHLPNIP 
                 491 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 6.4811 
               
               
                   
                 GVTSPGALIEDSK@ 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00131138.1 
                 AHVAPCFDAS*K@ 
                 492 
                   
                   
                 6.4769 
               
               
                   
               
               
                 IPI:IPI00757687.1 
                 LK@PDS*K@PFSR{circumflex over ( )} 
                 493 
                 Gon4l 
                 RIKEN cDNA 5830417I10 gene 
                 6.4593 
               
               
                   
               
               
                 IPI:IPI00121027.4 
                 ES*LS*HVLSK@ 
                 494 
                 Mogat1 
                 2-acylglycerol O-acyltransferase 1 
                 6.0819 
               
               
                   
               
               
                 IPI:IPI00115681.1 
                 TECGS*TGS*PASSFHFK@ 
                 495 
                 Eef2k 
                 Elongation factor 2 kinase 
                 5.912 
               
               
                   
               
               
                 IPI:IPI00115681.1 
                 TECGS*T*GSPASSFHFK@ 
                 496 
                 Eef2k 
                 Elongation factor 2 kinase 
                 5.912 
               
               
                   
               
               
                 IPI:IPI00128818.2 
                 LYTEK@AY*K@ 
                 497 
                 Dhx15 
                 Putative pre-mRNA-splicing factor ATP- 
                 5.9047 
               
               
                   
                   
                   
                   
                 dependent RNA helicase DHX15 
               
               
                   
               
               
                 IPI:IPI00118438.4 
                 SR{circumflex over ( )}VS*VS*PGR{circumflex over ( )} 
                 498 
                 Srrm1 
                 Isoform 2 of Serine/arginine repetitive 
                 5.834 
               
               
                   
                   
                   
                   
                 matrix protein 1 
               
               
                   
               
               
                 IPI:IPI00323238.5 
                 R{circumflex over ( )}K@T*VSFS*AAEEAPVPE 
                 499 
                 Setd1a 
                 SET domain containing 1A 
                 5.7891 
               
               
                   
                 PSTAAPLQAK@ 
               
               
                   
               
               
                 IPI:IPI00323238.5 
                 R{circumflex over ( )}K@T*VSFS*AAEEAPVPE 
                 500 
                 Setd1a 
                 SET domain containing 1A 
                 5.6797 
               
               
                   
                 PSTAAPLQAK@ 
               
               
                   
               
               
                 IPI:IPI00323238.5 
                 R{circumflex over ( )}K@T*VSFS*AAEEAPVPE 
                 501 
                 Setd1a 
                 SET domain containing 1A 
                 5.6797 
               
               
                   
                 PSTAAPLQAK@ 
               
               
                   
               
               
                 IPI:IPI00405470.1 
                 SGHSLLT*WDSAMSALSSA 
                 502 
                 D830015G02Rik 
                 Putative uncharacterized protein 
                 5.6705 
               
               
                   
                 S*SSSCCTLR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00137148.2 
                 R{circumflex over ( )}K@Y*GMLHTQESSSSVF 
                 503 
                 Vwa5b1 
                 von Willebrand factor A domain- 
                 5.6371 
               
               
                   
                 YPSQDEGLSPGSGNCAK@ 
                   
                   
                 containing protein 5B1 
               
               
                   
               
               
                 IPI:IPI00660767.2 
                 SDSS*GGYTLSDVIQS*PPS 
                 504 
                 Ibtk 
                 Isoform 2 of Inhibitor of Bruton 
                 5.5816 
               
               
                   
                 AGLLK@ 
                   
                   
                 tyrosine kinase 
               
               
                   
               
               
                 IPI:IPI00660767.2 
                 SDSS*GGYTLSDVIQS*PPS 
                 505 
                 Ibtk 
                 Isoform 2 of Inhibitor of Bruton 
                 5.4166 
               
               
                   
                 AGLLK@ 
                   
                   
                 tyrosine kinase 
               
               
                   
               
               
                 IPI:IPI00351206.5 
                 GLCSGPGAGEESPAAT*LP 
                 506 
                 Pgrmc2 
                 Membrane-associated progesterone 
                 5.4066 
               
               
                   
                 R{circumflex over ( )}M#K@ 
                   
                   
                 receptor component 2 
               
               
                   
               
               
                 IPI:IPI00117731.1 
                 TFWS*PELK@K@ 
                 507 
                 Erc1; 
                 Isoform 1 of ELKS/RAB6- 
                 5.3901 
               
               
                   
                   
                   
                 LOC100048600 
                 interacting/CAST family member 1 
               
               
                   
               
               
                 IPI:IPI00115681.1 
                 TECGS*TGSPAS*SFHFK@ 
                 508 
                 Eef2k 
                 Elongation factor 2 kinase 
                 5.3519 
               
               
                   
               
               
                 IPI:IPI00351206.5 
                 GLCSGPGAGEES*PAATLP 
                 509 
                 Pgrmc2 
                 Membrane-associated progesterone 
                 5.2793 
               
               
                   
                 R{circumflex over ( )}M#K@ 
                   
                   
                 receptor component 2 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 LSS*LR{circumflex over ( )}AS*TSK@SESSQK@ 
                 510 
                 rpS6 
                 29 kDa protein 
                 5.274 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 LSS*LR{circumflex over ( )}ASTS*K@SESSQK@ 
                 511 
                 rpS6 
                 29 kDa protein 
                 5.274 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 R{circumflex over ( )}LS*S*LR{circumflex over ( )} 
                 512 
                 rpS6 
                 29 kDa protein 
                 5.2699 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 RLS*S*LR 
                 513 
                 rpS6 
                 29 kDa protein 
                 5.2699 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 LS*SLR{circumflex over ( )}ASTS*K@SESSQK@ 
                 514 
                 rpS6 
                 29 kDa protein 
                 5.257 
               
               
                   
               
               
                 IPI:IPI00331280.1 
                 AALDQT*SGLPGGAAQDPG 
                 515 
                 Adamts2 
                 A disintegrin and metalloproteinase 
                 5.2222 
               
               
                   
                 GR{circumflex over ( )} 
                   
                   
                 with thrombospondin motifs 2 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 RLS*S*LR 
                 516 
                 rpS6 
                 29 kDa protein 
                 5.1769 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 R{circumflex over ( )}LS*S*LR{circumflex over ( )} 
                 517 
                 rpS6 
                 29 kDa protein 
                 5.1745 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILS*SQS*PLHPSTLNAVI 
                 518 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 5.0363 
               
               
                   
                 HR{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSS*QS*PLHPSTLNAVI 
                 519 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 5.0363 
               
               
                   
                 HR{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 SLVSPIPS*PTGTISVPNSCP 
                 520 
                 Foxk1 
                 Forkhead box protein K1 
                 5.0164 
               
               
                   
                 AS*PR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00461419.2 
                 IR{circumflex over ( )}S*S*LAR{circumflex over ( )} 
                 521 
                 Gm6988 
                 similar to hCG1640785 
                 4.998 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 R{circumflex over ( )}LS*S*LR{circumflex over ( )}ASTSK@ 
                 522 
                 rpS6 
                 29 kDa protein 
                 4.9653 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILS*SQS*PLHPSTLNAVI 
                 523 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 4.9297 
               
               
                   
                 HR{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00403938.2 
                 LLDPQEFT*LS*GT*QR{circumflex over ( )} 
                 524 
                 Tnc 
                 Isoform 1 of Tenascin 
                 4.9074 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 R{circumflex over ( )}LS*S*LR{circumflex over ( )}ASTSK@ 
                 525 
                 rpS6 
                 29 kDa protein 
                 4.8929 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 TASISSSPS*EGTPAVGS*Y 
                 526 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 4.8902 
               
               
                   
                 GCT*PQSLPK@ 
               
               
                   
               
               
                 IPI:IPI00169986.4 
                 SLLVLR{circumflex over ( )}GT*AYT*R{circumflex over ( )} 
                 527 
                 Alkbh6 
                 24 kDa protein 
                 4.8761 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSS*QS*PLHPSTLNAVI 
                 528 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 4.774 
               
               
                   
                 HR{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 T*ASISSS*PSEGTPAVGSY 
                 529 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 4.758 
               
               
                   
                 GCT*PQS*LPK@ 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 T*ASISSS*PSEGTPAVGSY* 
                 530 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 4.758 
               
               
                   
                 GCT*PQSLPK@ 
               
               
                   
               
               
                 IPI:IPI00115681.1 
                 TECGS*TGS*PASSFHFK@ 
                 531 
                 Eef2k 
                 Elongation factor 2 kinase 
                 4.7395 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 TAS*ISSS*PSEGTPAVGSY 
                 532 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 4.7282 
               
               
                   
                 GCT*PQS*LPK@ 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 M#NILSS*QS*PLHPSTLNAV 
                 533 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 4.7179 
               
               
                   
                 IHR{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00340860.5 
                 TAS*EGS*EAETPEAPK@Q 
                 534 
                 Larp7 
                 Isoform 1 of La-related protein 7 
                 4.7122 
               
               
                   
                 PAK@K@ 
               
               
                   
               
               
                 IPI:IPI00340860.5 
                 TAS*EGS*EAETPEAPK@Q 
                 535 
                 Larp7 
                 Isoform 1 of La-related protein 7 
                 4.7105 
               
               
                   
                 PAK@K@ 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSSQS*PLHPSTLNAVIH 
                 536 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 4.6623 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSSQS*PLHPSTLNAVIH 
                 537 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 4.6623 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 TASIS*SSPSEGT*PAVGSY 
                 538 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 4.5768 
               
               
                   
                 GCTPQS*LPK@ 
               
               
                   
               
               
                 IPI:IPI00115681.1 
                 TECGS*TGSPAS*SFHFK@ 
                 539 
                 Eef2k 
                 Elongation factor 2 kinase 
                 4.562 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 VK@T*PEMIIQK@PK@ 
                 540 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 4.557 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 T*ASISSS*PSEGTPAVGSY* 
                 541 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 4.4981 
               
               
                   
                 GCT*PQSLPK@ 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 TAS*ISSS*PSEGTPAVGSY 
                 542 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 4.4981 
               
               
                   
                 GCT*PQS*LPK@ 
               
               
                   
               
               
                 IPI:IPI00320208.3 
                 YGPSSVEDTTGSGAADAK 
                 543 
                 Eef1b2 
                 Elongation factor 1-beta 
                 4.4765 
               
               
                   
                 @DDDDIDLFGS*DDEEESE 
               
               
                   
                 EAK@K@ 
               
               
                   
               
               
                 IPI:IPI00320208.3 
                 YGPSSVEDTTGSGAADAKD 
                 544 
                 Eef1b2 
                 Elongation factor 1-beta 
                 4.4765 
               
               
                   
                 DDDIDLFGS*DDEEESEEAKK 
               
               
                   
               
               
                 IPI:IPI00474916.3 
                 AVVPFLGVGFSSLDMS*LCV 
                 545 
                 Qsox2 
                 Isoform 3 of Sulfhydryl oxidase 2 
                 4.4747 
               
               
                   
                 VLY*VASS*LFLM#IMYFFFR 
               
               
                   
                 {circumflex over ( )}VR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00399953.1 
                 K@FS*APGQLCVPMTSNLG 
                 546 
                 Wnk1 
                 Serine/threonine-protein kinase WNK1 
                 4.3426 
               
               
                   
                 GSTPISAASATSLGHFTK@ 
               
               
                   
               
               
                 IPI:IPI00654415.2 
                 MT*S*T*DYS*LSGTCGM#D 
                 547 
                 Megf11 
                 Isoform 4 of Multiple epidermal growth 
                 4.325 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 factor-like domains 11 
               
               
                   
               
               
                 IPI:IPI00660767.2 
                 SDS*SGGYTLSDVIQS*PPS 
                 548 
                 Ibtk 
                 Isoform 2 of Inhibitor of Bruton 
                 4.2681 
               
               
                   
                 AGLLK@ 
                   
                   
                 tyrosine kinase 
               
               
                   
               
               
                 IPI:IPI00660767.2 
                 K@R{circumflex over ( )}SDSSGGYT*LSDVIQS 
                 549 
                 Ibtk 
                 Isoform 2 of Inhibitor of Bruton 
                 4.2613 
               
               
                   
                 *PPSAGLLK@ 
                   
                   
                 tyrosine kinase 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSSQS*PLHPSTLNAVIH 
                 550 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 4.2564 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSSQSPLHPS*TLNAVIH 
                 551 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 4.2564 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 M#NILSSQS*PLHPSTLNAVI 
                 552 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 4.2332 
               
               
                   
                 HR{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00313653.2 
                 QFCQEGQPHVLEALS*PPQ 
                 553 
                 Maf1 
                 Repressor of RNA polymerase III 
                 4.2077 
               
               
                   
                 TSGLS*PSR{circumflex over ( )} 
                   
                   
                 transcription MAF1 homolog 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 TAS*ISSS*PSEGTPAVGSY 
                 554 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 4.18 
               
               
                   
                 GCT*PQS*LPK@ 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 M#NILSSQS*PLHPSTLNAVI 
                 555 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 4.1504 
               
               
                   
                 HR{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 M#NILSSQS*PLHPSTLNAVI 
                 556 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 4.1504 
               
               
                   
                 HR{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00122594.4 
                 EVS*VSS*VTEEPK@LDSSQ 
                 557 
                 Ahctf1 
                 AT-hook-containing transcription 
                 4.144 
               
               
                   
                 LPLQTGLDVPAT*PR{circumflex over ( )} 
                   
                   
                 factor 1 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSSQS*PLHPSTLNAVIH 
                 558 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 4.133 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSSQS*PLHPSTLNAVIH 
                 559 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 4.133 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 R{circumflex over ( )}NS*PMAQT*PPCHLPNIP 
                 560 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 4.0914 
               
               
                   
                 GVTSPGALIEDSK@ 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 R{circumflex over ( )}NS*PMAQT*PPCHLPNIP 
                 561 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 4.0914 
               
               
                   
                 GVTSPGALIEDSK@ 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00122521.1 
                 K@DELSDWS*LAGEDDR{circumflex over ( )}E 
                 562 
                 Fxr1 
                 Isoform E of Fragile X mental 
                 4.0773 
               
               
                   
                 TR{circumflex over ( )} 
                   
                   
                 retardation syndrome-related protein 1 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSS*QSPLHPSTLNAV 
                 563 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 4.0585 
               
               
                   
                 IHR 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILS*SQS*PLHPSTLNAVI 
                 564 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 4.0417 
               
               
                   
                 HR{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00313653.2 
                 QFCQEGQPHVLEALS*PPQ 
                 565 
                 Maf1 
                 Repressor of RNA polymerase III 
                 4.0213 
               
               
                   
                 TSGLS*PSR{circumflex over ( )} 
                   
                   
                 transcription MAF1 homolog 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSS*QSPLHPSTLNAV 
                 566 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 3.9734 
               
               
                   
                 IHR 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSSQS*PLHPSTLNAVIH 
                 567 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 3.9734 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSSQS*PLHPSTLNAVIH 
                 568 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 3.9734 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSS*QSPLHPSTLNAV 
                 569 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 3.9734 
               
               
                   
                 IHR 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00120691.3 
                 QADSET*K@EIITEEPS*EEE 
                 570 
                 Ddx21 
                 Nucleolar RNA helicase 2 
                 3.9589 
               
               
                   
                 ADMPK@PK@ 
               
               
                   
               
               
                 IPI:IPI00226441.2 
                 LHYT*PPLQS*PIT*DGDPLL 
                 571 
                 Lin9 
                 Isoform 2 of Lin-9 homolog 
                 3.8536 
               
               
                   
                 GQS*PWR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSSQS*PLHPSTLNAVIH 
                 572 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 3.8383 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILSSQS*PLHPSTLNAVIH 
                 573 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 3.8383 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 SSGLQTPECLS*REGS*PIP 
                 574 
                 Foxk1 
                 Forkhead box protein K1 
                 3.7948 
               
               
                   
                 HDPDLGSK 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 SSGLQTPECLS*R{circumflex over ( )}EGS*PIP 
                 575 
                 Foxk1 
                 Forkhead box protein K1 
                 3.7948 
               
               
                   
                 HDPDLGSK@ 
               
               
                   
               
               
                 IPI:IPI00468516.3 
                 SHILESVPTLPGS*VEAGVS 
                 576 
                 D6Wsu116e 
                 Isoform 1 of Protein FAM21 
                 3.7932 
               
               
                   
                 FDLPAQADTLHSANK@ 
               
               
                   
               
               
                 IPI:IPI00751009.1 
                 TSEFPTPLFSGPLEPVACGS 
                 577 
                 Srpk2 
                 serine/arginine-rich protein-specific 
                 3.7653 
               
               
                   
                 VISEGSPLTEQEESSPSHDR 
                   
                   
                 kinase 2 
               
               
                   
                 {circumflex over ( )}S*R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 TASISSSPS*EGTPAVGSYG 
                 578 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 3.756 
               
               
                   
                 CT*PQS*LPK@ 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 TASISSSPS*EGTPAVGSY* 
                 579 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 3.756 
               
               
                   
                 GCT*PQSLPK@ 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 SSGLQTPECLS*R{circumflex over ( )}EGS*PIP 
                 580 
                 Foxk1 
                 Forkhead box protein K1 
                 3.7214 
               
               
                   
                 HDPDLGSK@ 
               
               
                   
               
               
                 IPI:IPI00400017.2 
                 TQS*GNFNTDAPGMAEFR{circumflex over ( )} 
                 581 
                 Ppfibp2 
                 Isoform 4 of Liprin-beta-2 
                 3.6603 
               
               
                   
               
               
                 IPI:IPI00660767.2 
                 SDSS*GGYTLSDVIQS*PPS 
                 582 
                 Ibtk 
                 Isoform 2 of Inhibitor of Bruton 
                 3.6519 
               
               
                   
                 AGLLK@ 
                   
                   
                 tyrosine kinase 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 S*EGLSLER{circumflex over ( )} 
                 583 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 3.6501 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00379844.4 
                 TAS*EGDGGAAGGAGTAG 
                 584 
                 Irs2 
                 Insulin receptor substrate 2 
                 3.6492 
               
               
                   
                 GR{circumflex over ( )}PMSVAGS*PLS*PGPVR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 T*ASISSS*PSEGTPAVGS*Y 
                 585 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 3.6217 
               
               
                   
                 GCTPQSLPK@ 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 T*ASISSS*PSEGTPAVGS*Y 
                 586 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 3.6217 
               
               
                   
                 GCTPQSLPK@ 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 R{circumflex over ( )}S*EGLSLER{circumflex over ( )} 
                 587 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 3.6142 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 SLVS*PIPSPTGT*ISVPNSC 
                 588 
                 Foxk1 
                 Forkhead box protein K1 
                 3.6065 
               
               
                   
                 PAS*PR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 SLVS*PIPS*PTGTISVPNSC 
                 589 
                 Foxk1 
                 Forkhead box protein K1 
                 3.6065 
               
               
                   
                 PAS*PR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 SLVSPIPSPT*GTISVPNSCP 
                 590 
                 Foxk1 
                 Forkhead box protein K1 
                 3.605 
               
               
                   
                 AS*PR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00654417.1 
                 HSS*PPLTVK 
                 591 
                 Tinf2 
                 Putative uncharacterized protein 
                 3.5562 
               
               
                   
               
               
                 IPI:IPI00830829.1 
                 R{circumflex over ( )}R{circumflex over ( )}SGEQIT*SS*PVS*PK@ 
                 592 
                 Hisppd1 
                 140 kDa protein 
                 3.5492 
               
               
                   
               
               
                 IPI:IPI00118875.4 
                 GATPAEDDEDKDIDLFGS*D 
                 593 
                 Eef1d 
                 eukaryotic translation elongation 
                 3.5469 
               
               
                   
                 EEEEDKEAAR 
                   
                   
                 factor 1 delta isoform a 
               
               
                   
               
               
                 IPI:IPI00118875.4 
                 GATPAEDDEDKDIDLFGS*D 
                 594 
                 Eef1d 
                 eukaryotic translation elongation 
                 3.5469 
               
               
                   
                 EEEEDKEAAR 
                   
                   
                 factor 1 delta isoform a 
               
               
                   
               
               
                 IPI:IPI00169888.3 
                 SQDVAIS*PQQQQCSK@S* 
                 595 
                 Edc3 
                 Enhancer of mRNA-decapping protein 3 
                 3.5277 
               
               
                   
                 YVDR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00134029.8 
                 VS*SS*VS*VGPSM#SGET*L 
                 596 
                 Aim1l 
                 Absent in melanoma 1-like 
                 3.5092 
               
               
                   
                 PR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00654417.1 
                 HSS*PPLTVK 
                 597 
                 Tinf2 
                 Putative uncharacterized protein 
                 3.4997 
               
               
                   
               
               
                 IPI:IPI00676574.2 
                 RVS*TDLPEGQDVYTAACN 
                 598 
                 Herc1 
                 hect (homologous to the E6-AP 
                 3.4866 
               
               
                   
                 SVIHR 
                   
                   
                 (UBE3A) carboxyl terminus) domain 
               
               
                   
                   
                   
                   
                 and RCC1 (CHC1)-like domain (RLD) 1 
               
               
                   
               
               
                 IPI:IPI00762234.2 
                 SGDPR{circumflex over ( )}S*CEEES*DPEPDP 
                 599 
                 Fbxw9 
                 F-box and WD-40 domainprotein 9 
                 3.4479 
               
               
                   
                 DPDTQAEAYVAR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00660767.2 
                 VDTAASSSWLAGS*CS*PVS 
                 600 
                 Ibtk 
                 Isoform 2 of Inhibitor of Bruton 
                 3.398 
               
               
                   
                 PPVVDLR{circumflex over ( )} 
                   
                   
                 tyrosine kinase 
               
               
                   
               
               
                 IPI:IPI00169888.3 
                 SQDVAIS*PQQQQCS*K@S 
                 601 
                 Edc3 
                 Enhancer of mRNA-decapping protein 3 
                 3.3665 
               
               
                   
                 YVDR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00169888.3 
                 SQDVAISPQQQQCS*K@SY 
                 602 
                 Edc3 
                 Enhancer of mRNA-decapping protein 3 
                 3.3665 
               
               
                   
                 *VDR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00122521.1 
                 K@DELSDWS*LAGEDDR{circumflex over ( )}E 
                 603 
                 Fxr1 
                 Isoform E of Fragile X mental 
                 3.3379 
               
               
                   
                 TR{circumflex over ( )} 
                   
                   
                 retardation syndrome-related protein 1 
               
               
                   
               
               
                 IPI:IPI00761443.2 
                 RSS*AGS*LESNVEGSIISS* 
                 604 
                 Iqsec1 
                 IQ motif and Sec7 domain 1 isoform b 
                 3.3179 
               
               
                   
                 PHMR 
               
               
                   
               
               
                 IPI:IPI00761443.2 
                 R{circumflex over ( )}S*SAGS*LESNVEGSIISS* 
                 605 
                 Iqsec1 
                 IQ motif and Sec7 domain 1 isoform b 
                 3.3179 
               
               
                   
                 PHMR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00828461.1 
                 GPPDFS*S*DEER{circumflex over ( )}EPTPVL 
                 606 
                 Tmpo 
                 thymopoietin isoform delta 
                 3.3038 
               
               
                   
                 GSGASVGR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00828461.1 
                 GPPDFS*S*DEER{circumflex over ( )}EPTPVL 
                 607 
                 Tmpo 
                 thymopoietin isoform delta 
                 3.3038 
               
               
                   
                 GSGASVGR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00126317.1 
                 NAS*TS*FQELEDK@K@EL 
                 608 
                 Dnajc2 
                 DnaJ homolog subfamily C member 2 
                 3.2768 
               
               
                   
                 SEESEDEELQLEEFPMLK@ 
               
               
                   
               
               
                 IPI:IPI00227934.3 
                 TSASCS*PAPES*PMSSSES 
                 609 
                 Cux1 
                 cut-like homeobox 1 isoform a 
                 3.1887 
               
               
                   
                 VK@ 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 S*EGLSLER{circumflex over ( )} 
                 610 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 3.1751 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00468516.3 
                 SHILESVPTLPGS*VEAGVS 
                 611 
                 D6Wsu116e 
                 Isoform 1 of Protein FAM21 
                 3.1635 
               
               
                   
                 FDLPAQADTLHSANK@ 
               
               
                   
               
               
                 IPI:IPI00468516.3 
                 SHILESVPTLPGS*VEAGVS 
                 612 
                 D6Wsu116e 
                 Isoform 1 of Protein FAM21 
                 3.1635 
               
               
                   
                 FDLPAQADTLHSANK@ 
               
               
                   
               
               
                 IPI:IPI00762234.2 
                 SGDPR{circumflex over ( )}S*CEEES*DPEPDP 
                 613 
                 Fbxw9 
                 F-box and WD-40 domain protein 9 
                 3.1508 
               
               
                   
                 DPDTQAEAYVAR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00320208.3 
                 YGPSSVEDTTGSGAADAKD 
                 614 
                 Eef1b2 
                 Elongation factor 1-beta 
                 3.1436 
               
               
                   
                 DDDIDLFGS*DDEEESEEAKK 
               
               
                   
               
               
                 IPI:IPI00320594.5 
                 SQPHSSTSNQETS*DS*EM 
                 615 
                 Ranbp10 
                 Ran-binding protein 10 
                 3.1377 
               
               
                   
                 EMEAEHYPNGVLESVSTR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00808277.2 
                 S*APASPNHAGVLSAHSSG 
                 616 
                 Foxk2 
                 Isoform 1 of Forkhead box protein K2 
                 3.1204 
               
               
                   
                 AQTPES*LSR{circumflex over ( )}EGS*PAPLE 
               
               
                   
                 PEPGASQPK@ 
               
               
                   
               
               
                 IPI:IPI00808277.2 
                 SAPAS*PNHAGVLSAHSSG 
                 617 
                 Foxk2 
                 Isoform 1 of Forkhead box protein K2 
                 3.1105 
               
               
                   
                 AQTPES*LSR{circumflex over ( )}EGS*PAPLE 
               
               
                   
                 PEPGASQPK@ 
               
               
                   
               
               
                 IPI:IPI00753321.2 
                 S*VSETSEDK@K@DEES*D 
                 618 
                 Bod1l 
                 biorientation of chromosomes in cell 
                 3.106 
               
               
                   
                 EEEEEEEEEEPLGATTR{circumflex over ( )} 
                   
                   
                 division 1-like 
               
               
                   
               
               
                 IPI:IPI00420464.3 
                 SNT*PS*PLNLSSTSSK@ 
                 619 
                 Zeb2 
                 Zinc finger E-box-binding homeobox 2 
                 3.0996 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 S*EGLSLER{circumflex over ( )} 
                 620 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 3.0974 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00808277.2 
                 SAPAS*PNHAGVLSAHSSG 
                 621 
                 Foxk2 
                 Isoform 1 of Forkhead box protein K2 
                 3.0877 
               
               
                   
                 AQT*PES*LSR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00830829.1 
                 R{circumflex over ( )}R{circumflex over ( )}S*GEQITSS*PVS*PK@ 
                 622 
                 Hisppd1 
                 140 kDa protein 
                 3.0712 
               
               
                   
               
               
                 IPI:IPI00117932.2 
                 S*PPVQPHTPVTISLGTAPS 
                 623 
                 Sin3a 
                 Isoform 1 of Paired amphipathic helix 
                 3.0565 
               
               
                   
                 LQNNQPVEFNHAINYVNK@ 
                   
                   
                 protein Sin3a 
               
               
                   
               
               
                 IPI:IPI00117932.2 
                 S*PPVQPHTPVTISLGTAPS 
                 624 
                 Sin3a 
                 Isoform 1 of Paired amphipathic helix 
                 3.0565 
               
               
                   
                 LQNNQPVEFNHAINYVNK@ 
                   
                   
                 protein Sin3a 
               
               
                   
               
               
                 IPI:IPI00320594.5 
                 SQPHSSTSNQETS*DS*EM 
                 625 
                 Ranbp10 
                 Ran-binding protein 10 
                 3.0328 
               
               
                   
                 EMEAEHYPNGVLESVSTR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00227934.3 
                 TS*ASCSPAPES*PMSSSES 
                 626 
                 Cux1 
                 cut-like homeobox 1 isoform a 
                 3.0118 
               
               
                   
                 VK@ 
               
               
                   
               
               
                 IPI:IPI00380817.6 
                 GR{circumflex over ( )}SS*ESSCGLDGDYEDA 
                 627 
                 Bcr 
                 Breakpoint cluster region protein 
                 3.0087 
               
               
                   
                 ELNPR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 SLVSPIPS*PTGTISVPNSCP 
                 628 
                 Foxk1 
                 Forkhead box protein K1 
                 2.9994 
               
               
                   
                 AS*PR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 SLVS*PIPS*PTGTISVPNSC 
                 629 
                 Foxk1 
                 Forkhead box protein K1 
                 2.9989 
               
               
                   
                 PAS*PR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00127976.1 
                 MNILS*SQS*PLHPSTLNAVI 
                 630 
                 Grb10 
                 Isoform 3 of Growth factor receptor- 
                 2.9784 
               
               
                   
                 HR{circumflex over ( )} 
                   
                   
                 bound protein 10 
               
               
                   
               
               
                 IPI:IPI00551454.3 
                 ER{circumflex over ( )}QES*ESEQELVNK@ 
                 631 
                 Pdcd11 
                 Protein RRP5 homolog 
                 2.9603 
               
               
                   
               
               
                 IPI:IPI00226155.3 
                 VSALEEDMDDVES*S*EEEE 
                 632 
                 Prpf38a 
                 Isoform 1 of Pre-mRNA-splicing factor 
                 2.9547 
               
               
                   
                 EEDEKLER 
                   
                   
                 38A 
               
               
                   
               
               
                 IPI:IPI00753321.2 
                 SVSETS*EDK@K@DEES*D 
                 633 
                 Bod1l 
                 biorientation of chromosomes in cell 
                 2.9525 
               
               
                   
                 EEEEEEEEEEPLGATTR{circumflex over ( )} 
                   
                   
                 division 1-like 
               
               
                   
               
               
                 IPI:IPI00753321.2 
                 SVSET*SEDK@K@DEES*D 
                 634 
                 Bod1l 
                 biorientation of chromosomes in cell 
                 2.9525 
               
               
                   
                 EEEEEEEEEEPLGATTR{circumflex over ( )} 
                   
                   
                 division 1-like 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 LSS*LR{circumflex over ( )}ASTS*K@S*ESSQ 
                 635 
                 — 
                 29 kDa protein 
                 2.9394 
               
               
                   
                 K@ 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 HR{circumflex over ( )}SNS*FS*DER{circumflex over ( )}EFSAPS* 
                 636 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 2.9368 
               
               
                   
                 TPTGTLEFAGGDAK@ 
               
               
                   
               
               
                 IPI:IPI00551454.3 
                 ER{circumflex over ( )}QES*ESEQELVNK@ 
                 637 
                 Pdcd11 
                 Protein RRP5 homolog 
                 2.9308 
               
               
                   
               
               
                 IPI:IPI00468516.3 
                 SHILESVPTLPGS*VEAGVS 
                 638 
                 D6Wsu116e 
                 Isoform 1 of Protein FAM21 
                 2.9286 
               
               
                   
                 FDLPAQADTLHSANK@ 
               
               
                   
               
               
                 IPI:IPI00420464.3 
                 SNT*PS*PLNLSSTSSK@ 
                 639 
                 Zeb2 
                 Zinc finger E-box-binding homeobox 2 
                 2.9204 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 SLVS*PIPS*PTGTISVPNSC 
                 640 
                 Foxk1 
                 Forkhead box protein K1 
                 2.8837 
               
               
                   
                 PAS*PR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 K@MLLASTSSDDFDR{circumflex over ( )}AS* 
                 641 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 2.8699 
               
               
                   
                 Y*SGTSPSHSFISGEPDR{circumflex over ( )} 
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00551454.3 
                 ER{circumflex over ( )}QES*ESEQELVNK@ 
                 642 
                 Pdcd11 
                 Protein RRP5 homolog 
                 2.8488 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 SLVS*PIPSPT*GTISVPN 
                 643 
                 Foxk1 
                 Forkhead box protein K1 
                 2.818 
               
               
                   
                 S*CPASPR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00660767.2 
                 VDTAASSSWLAGS*CS*PVS 
                 644 
                 Ibtk 
                 Isoform 2 of Inhibitor of Bruton 
                 2.8109 
               
               
                   
                 PPVVDLR{circumflex over ( )} 
                   
                   
                 tyrosine kinase 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 SLVS*PIPS*PTGTISVPNSC 
                 645 
                 Foxk1 
                 Forkhead box protein K1 
                 2.8019 
               
               
                   
                 PAS*PR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 SLVS*PIPS*PTGTISVPNSC 
                 646 
                 Foxk1 
                 Forkhead box protein K1 
                 2.8019 
               
               
                   
                 PAS*PR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00656285.2 
                 SLVSPIPSPT*GT*ISVPNSC 
                 647 
                 Foxk1 
                 Forkhead box protein K1 
                 2.8019 
               
               
                   
                 PAS*PR 
               
               
                   
               
               
                 IPI:IPI00107958.1 
                 TSDIFGS*PVTATAPLAHPN 
                 648 
                 Hn1l 
                 Hematological and neurological 
                 2.7751 
               
               
                   
                 K@PK@ 
                   
                   
                 expressed 1-like protein 
               
               
                   
               
               
                 IPI:IPI00129298.1 
                 EIDVLEFGESAPAASKENSA 
                 649 
                 Palm 
                 Isoform 1 of Paralemmin 
                 2.7684 
               
               
                   
                 APS*PGRPQSASPAKEEQK 
               
               
                   
               
               
                 IPI:IPI00320208.3 
                 YGPSSVEDTTGSGAADAK 
                 650 
                 Eef1b2 
                 Elongation factor 1-beta 
                 2.7577 
               
               
                   
                 @DDDDIDLFGS*DDEEESE 
               
               
                   
                 EAK@K@ 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 TASISSS*PSEGT*PAVGSY 
                 651 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 2.7577 
               
               
                   
                 GCT*PQS*LPK@ 
               
               
                   
               
               
                 IPI:IPI00377615.2 
                 R{circumflex over ( )}SS*R{circumflex over ( )}S*FSLDEPPLFIPD 
                 652 
                 Phf3 
                 PHD finger protein 3 
                 2.7452 
               
               
                   
                 NIATVK@ 
               
               
                   
               
               
                 IPI:IPI00113563.3 
                 YMEDST*YY*K@ASK@ 
                 653 
                 Ptk2 
                 Isoform 1 of Focal adhesion kinase 1 
                 2.7394 
               
               
                   
               
               
                 IPI:IPI00553283.1 
                 MMPS*PSDSSR{circumflex over ( )} 
                 654 
                 1110013L07Rik 
                 Putative uncharacterized protein 
                 2.7037 
               
               
                   
               
               
                 IPI:IPI00314502.5 
                 VHGLPTTSPS*GVNMAELA 
                 655 
                 Tcfeb 
                 Transcription factor EB 
                 2.6958 
               
               
                   
                 QQVVK@ 
               
               
                   
               
               
                 IPI:IPI00314502.5 
                 VHGLPTTSPS*GVNMAELA 
                 656 
                 Tcfeb 
                 Transcription factor EB 
                 2.6958 
               
               
                   
                 QQVVK@ 
               
               
                   
               
               
                 IPI:IPI00122594.4 
                 EVS*VSS*VTEEPK@LDSSQ 
                 657 
                 Ahctf1 
                 AT-hook-containing transcription 
                 2.6674 
               
               
                   
                 LPLQTGLDVPAT*PR{circumflex over ( )} 
                   
                   
                 factor 1 
               
               
                   
               
               
                 IPI:IPI00377615.2 
                 S*S*R{circumflex over ( )}SFSLDEPPLFIPDNIA 
                 658 
                 Phf3 
                 PHD finger protein 3 
                 2.6537 
               
               
                   
                 TVK@K@ 
               
               
                   
               
               
                 IPI:IPI00468516.3 
                 SHILESVPTLPGS*VEAGVS 
                 659 
                 D6Wsu116e 
                 Isoform 1 of Protein FAM21 
                 2.6436 
               
               
                   
                 FDLPAQADTLHSANK@ 
               
               
                   
               
               
                 IPI:IPI00122521.1 
                 SSISSVLK@DPDSNPYSLLD 
                 660 
                 Fxr1 
                 Isoform E of Fragile X mental 
                 2.618 
               
               
                   
                 NTES*DQTADT*DAS*ESHH 
                   
                   
                 retardation syndrome-related protein 1 
               
               
                   
                 STNR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00625723.2 
                 TGTGSPFAGNS*PAR{circumflex over ( )}EGE 
                 661 
                 Zc3h4 
                 Isoform 2 of Zinc finger CCCH domain- 
                 2.5583 
               
               
                   
                 QDAGSLK@DVFK@ 
                   
                   
                 containing protein 4 
               
               
                   
               
               
                 IPI:IPI00625723.2 
                 TGTGSPFAGNS*PAR{circumflex over ( )}EGE 
                 662 
                 Zc3h4 
                 Isoform 2 of Zinc finger CCCH domain- 
                 2.5583 
               
               
                   
                 QDAGSLK@DVFK@ 
                   
                   
                 containing protein 4 
               
               
                   
               
               
                 IPI:IPI00122559.3 
                 EIQNGTLR{circumflex over ( )}ES*DSEHVPR{circumflex over ( )} 
                 663 
                 Ktn1 
                 isoform 1 of Kinectin 
                 2.5547 
               
               
                   
               
               
                 IPI:IPI00136379.1 
                 GGGSAAAAAAAAASGGGV 
                 664 
                 Pbx2 
                 Pre-B-cell leukemia transcription 
                 2.554 
               
               
                   
                 S*PDNSIEHSDYR{circumflex over ( )} 
                   
                 factor 2 
               
               
                   
               
               
                 IPI:IPI00330246.2 
                 SGPLPSSSGSSSSSSQLSV 
                 665 
                 Phldb1 
                 Isoform 2 of Pleckstrin homology-like 
                 2.5309 
               
               
                   
                 AT*LGR{circumflex over ( )}SPS*PK@ 
                   
                   
                 domain family B member 1 
               
               
                   
               
               
                 IPI:IPI00330246.2 
                 SGPLPSSSGSSSSSSQLSV 
                 666 
                 Phldb1 
                 Isoform 2 of Pleckstrin homology-like 
                 2.5309 
               
               
                   
                 AT*LGR{circumflex over ( )}SPS*PK@ 
                   
                   
                 domain family B member 1 
               
               
                   
               
               
                 IPI:IPI00377615.2 
                 S*S*R{circumflex over ( )}SFSLDEPPLFIPDNIA 
                 667 
                 Phf3 
                 PHD finger protein 3 
                 2.5121 
               
               
                   
                 TVK@K@ 
               
               
                   
               
               
                 IPI:IPI00125505.2 
                 TTGNSHWTLEAPFSSS*CA 
                 668 
                 Cdgap 
                 Cdc42 GTPase-activating protein 
                 2.4733 
               
               
                   
                 NLETER{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00551454.3 
                 ER{circumflex over ( )}QES*ESEQELVNK@ 
                 669 
                 Pdcd11 
                 Protein RRP5 homolog 
                 2.4392 
               
               
                   
               
               
                 IPI:IPI00320594.5 
                 SQPHSSTSNQETS*DS*EM 
                 670 
                 Ranbp10 
                 Ran-binding protein 10 
                 2.4384 
               
               
                   
                 EMEAEHYPNGVLESVSTR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00126317.1 
                 NAS*TS*FQELEDK@K@EL 
                 671 
                 Dnajc2 
                 DnaJ homolog subfamily C member 2 
                 2.438 
               
               
                   
                 SEESEDEELQLEEFPMLK@ 
               
               
                   
               
               
                 IPI:IPI00129276.2 
                 LES*LNIQR{circumflex over ( )} 
                 672 
                 Eif3a 
                 Eukaryotic translation initiation 
                 2.429 
               
               
                   
                   
                   
                   
                 factor 3 subunit A 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 SS*EVVLS*GDDEDYQR{circumflex over ( )} 
                 673 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 2.4187 
               
               
                   
               
               
                 IPI:IPI00226750.2 
                 T*S*S*TCSNESLNAGGTPV 
                 674 
                 Tbc1d4 
                 140 kDa protein 
                 2.4185 
               
               
                   
                 TPR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00377615.2 
                 R{circumflex over ( )}SSR{circumflex over ( )}S*FS*LDEPPLFIPD 
                 675 
                 Phf3 
                 PHD finger protein 3 
                 2.409 
               
               
                   
                 NIATVK@ 
               
               
                   
               
               
                 IPI:IPI00377615.2 
                 R{circumflex over ( )}SSR{circumflex over ( )}S*FS*LDEPPLFIPD 
                 676 
                 Phf3 
                 PHD finger protein 3 
                 2.409 
               
               
                   
                 NIATVK@ 
               
               
                   
               
               
                 IPI:IPI00114227.7 
                 SIST*CGPLDK@DDPGGQK@ 
                 677 
                 Dennd4a 
                 hypothetical protein LOC102442 
                 2.3733 
               
               
                   
               
               
                 IPI:IPI00339693.1 
                 LGDSELALVCSQR{circumflex over ( )}PAS*LS 
                 678 
                 Wdr91 
                 WD repeat-containing protein 91 
                 2.3532 
               
               
                   
                 QSPR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00137166.1 
                 SR{circumflex over ( )}DAT*PPVS*PINMEDQE 
                 679 
                 Junb 
                 Transcription factor jun-B 
                 2.3444 
               
               
                   
                 R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00751009.1 
                 TVS*ASS*TGDLPK@ 
                 680 
                 Srpk2 
                 serine/arginine-rich protein-specific 
                 2.3444 
               
               
                   
                   
                   
                   
                 kinase 2 
               
               
                   
               
               
                 IPI:IPI00751009.1 
                 TVS*ASS*TGDLPK@ 
                 681 
                 Srpk2 
                 serine/arginine-rich protein-specific 
                 2.3444 
               
               
                   
                   
                   
                   
                 kinase 2 
               
               
                   
               
               
                 IPI:IPI00751009.1 
                 TVS*ASS*TGDLPK 
                 682 
                 Srpk2 
                 serine/arginine-rich protein-specific 
                 2.3444 
               
               
                   
                   
                   
                   
                 kinase 2 
               
               
                   
               
               
                 IPI:IPI00226750.2 
                 TSST*CS*NESLNAGGTPVT 
                 683 
                 Tbc1d4 
                 140 kDa protein 
                 2.3429 
               
               
                   
                 PR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00221581.1 
                 SR{circumflex over ( )}T*GS*ESSQTGASATSG 
                 684 
                 Eif4b 
                 Eukaryotic translation initiation 
                 2.3268 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 factor 4B 
               
               
                   
               
               
                 IPI:IPI00122521.1 
                 SSISSVLK@DPDSNPYSLLD 
                 685 
                 Fxr1 
                 Isoform E of Fragile X mental 
                 2.3266 
               
               
                   
                 NTES*DQT*ADT*DASESHH 
                   
                   
                 retardation syndrome-related protein 1 
               
               
                   
                 STNR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 K@R{circumflex over ( )}S*EGLS*LER{circumflex over ( )} 
                 686 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 2.3042 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00828461.1 
                 GPPDFS*S*DEER{circumflex over ( )}EPT*PVL 
                 687 
                 Tmpo 
                 thymopoietin isoform delta 
                 2.3011 
               
               
                   
                 GS*GASVGR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00463493.1 
                 S*ATDADMVNSGWLVVGK 
                 688 
                 Gbf1 
                 Golgi-specific brefeldin A-resistance 
                 2.294 
               
               
                   
                   
                   
                   
                 factor 1 
               
               
                   
               
               
                 IPI:IPI00129276.2 
                 LES*LNIQR{circumflex over ( )} 
                 689 
                 Eif3a 
                 Eukaryotic translation initiation 
                 2.2772 
               
               
                   
                   
                   
                   
                 factor 3 subunit A 
               
               
                   
               
               
                 IPI:IPI00751009.1 
                 TVS*ASS*TGDLPK@ 
                 690 
                 Srpk2 
                 serine/arginine-rich protein-specific 
                 2.2686 
               
               
                   
                   
                   
                   
                 kinase 2 
               
               
                   
               
               
                 IPI:IPI00137166.1 
                 SR{circumflex over ( )}DAT*PPVS*PINMEDQE 
                 691 
                 Junb 
                 Transcription factor jun-B 
                 2.2666 
               
               
                   
                 R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00221581.1 
                 SR{circumflex over ( )}TGS*ESS*QTGASATSG 
                 692 
                 Eif4b 
                 Eukaryotic translation initiation 
                 2.2646 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 factor 4B 
               
               
                   
               
               
                 IPI:IPI00221581.1 
                 SR{circumflex over ( )}TGS*ESS*QTGASATSG 
                 693 
                 Eif4b 
                 Eukaryotic translation initiation 
                 2.2646 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 factor 4B 
               
               
                   
               
               
                 IPI:IPI00221581.1 
                 SRT*GS*ESSQTGASATSGR 
                 694 
                 Eif4b 
                 Eukaryotic translation initiation 
                 2.2646 
               
               
                   
                   
                   
                   
                 factor 4B 
               
               
                   
               
               
                 IPI:IPI00268688.3 
                 TSS*S*ETEEK@K@TEK@P 
                 695 
                 Cd2ap 
                 CD2-associated protein 
                 2.2567 
               
               
                   
                 LILQPLGSR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00268688.3 
                 TSS*S*ETEEKKTEKPLILQP 
                 696 
                 Cd2ap 
                 CD2-associated protein 
                 2.2567 
               
               
                   
                 LGSR 
               
               
                   
               
               
                 IPI:IPI00226750.2 
                 TSST*CS*NES*LNAGGTPV 
                 697 
                 Tbc1d4 
                 140 kDa protein 
                 2.2548 
               
               
                   
                 TPR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00221581.1 
                 SRT*GS*ESSQTGASATSGR 
                 698 
                 Eif4b 
                 Eukaryotic translation initiation 
                 2.2395 
               
               
                   
                   
                   
                   
                 factor 4B 
               
               
                   
               
               
                 IPI:IPI00221581.1 
                 SR{circumflex over ( )}TGS*ESS*QTGASATSG 
                 699 
                 Eif4b 
                 Eukaryotic translation initiation 
                 2.2395 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 factor 4B 
               
               
                   
               
               
                 IPI:IPI00122594.4 
                 EVS*VSS*VTEEPK@LDSSQ 
                 700 
                 Ahctf1 
                 AT-hook-containing transcription 
                 2.2291 
               
               
                   
                 LPLQTGLDVPATPR{circumflex over ( )} 
                   
                   
                 factor 1 
               
               
                   
               
               
                 IPI:IPI00122594.4 
                 EVSVS*S*VTEEPKLDSSQL 
                 701 
                 Ahctf1 
                 AT-hook-containing transcription 
                 2.2291 
               
               
                   
                 PLQTGLDVPATPR 
                   
                   
                 factor 1 
               
               
                   
               
               
                 IPI:IPI00676574.2 
                 RVST*DLPEGQDVYTAACN 
                 702 
                 Herc1 
                 hect (homologous to the E6-AP 
                 2.2125 
               
               
                   
                 SVIHR 
                   
                   
                 (UBE3A) carboxyl terminus) domain 
               
               
                   
                   
                   
                   
                 and RCC1 (CHC1)-like domain (RLD) 1 
               
               
                   
               
               
                 IPI:IPI00268688.3 
                 TSS*S*ETEEK@K@TEK@P 
                 703 
                 Cd2ap 
                 CD2-associated protein 
                 2.1992 
               
               
                   
                 LILQPLGSR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00320905.7 
                 LGEQGPEPGPT*PPQTPT*P 
                 704 
                 Arhgap17 
                 Isoform 1 of Rho GTPase-activating 
                 2.1798 
               
               
                   
                 PS*TPPLAK 
                   
                   
                 protein 17 
               
               
                   
               
               
                 IPI:IPI00108454.2 
                 LSSLRAS*TS*KSES*S*QK 
                 705 
                 — 
                 29 kDa protein 
                 2.1655 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 TASIS*S*SPSEGTPAVGSY 
                 706 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 2.1557 
               
               
                   
                 GCT*PQSLPK@ 
               
               
                   
               
               
                 IPI:IPI00381495.5 
                 TVSSPIPYTPSPSSSR{circumflex over ( )}PIS* 
                 707 
                 Ccdc6 
                 coiled-coil domain containing 6 
                 2.1555 
               
               
                   
                 PGLSY*ASHTVGFTPPTSLT 
               
               
                   
                 R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00221581.1 
                 TGS*ESS*QTGASATSGR{circumflex over ( )} 
                 708 
                 Eif4b 
                 Eukaryotic translation initiation 
                 2.1437 
               
               
                   
                   
                   
                   
                 factor 4B 
               
               
                   
               
               
                 IPI:IPI00221581.1 
                 TGS*ESS*QTGASATSGR{circumflex over ( )} 
                 709 
                 Eif4b 
                 Eukaryotic translation initiation 
                 2.1437 
               
               
                   
                   
                   
                   
                 factor 4B 
               
               
                   
               
               
                 IPI:IPI00137166.1 
                 SR{circumflex over ( )}DAT*PPVS*PINMEDQE 
                 710 
                 Junb 
                 Transcription factor jun-B 
                 2.1419 
               
               
                   
                 R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 S*LPTTVPES*PNYR{circumflex over ( )} 
                 711 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 2.1397 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 S*LPTTVPESPNY*R 
                 712 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 2.1397 
               
               
                   
               
               
                 IPI:IPI00406045.3 
                 SESSAGICVPLSTS*PQVSE 
                 713 
                 Pik3r4 
                 Phosphoinositide 3-kinase regulatory 
                 2.1394 
               
               
                   
                 AAHIPSK@K@PVIPVVSST 
                   
                   
                 subunit 4 
               
               
                   
                 VLPSTYQIR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00122594.4 
                 ER{circumflex over ( )}EVS*VS*SVTEEPK@LD 
                 714 
                 Ahctf1 
                 AT-hook-containing transcription 
                 2.1312 
               
               
                   
                 SSQLPLQTGLDVPATPR{circumflex over ( )} 
                   
                   
                 factor 1 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 S*LPTTVPES*PNYR{circumflex over ( )} 
                 715 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 2.1207 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 S*LPTTVPES*PNYR 
                 716 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 2.1207 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 SLPT*TVPES*PNYR{circumflex over ( )} 
                 717 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 2.1207 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 S*LPTTVPES*PNYR 
                 718 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 2.1207 
               
               
                   
               
               
                 IPI:IPI00625723.2 
                 TGTGSPFAGNS*PAR{circumflex over ( )}EGE 
                 719 
                 Zc3h4 
                 Isoform 2 of Zinc finger CCCH domain- 
                 2.1078 
               
               
                   
                 QDAGSLK@DVFK@ 
                   
                   
                 containing protein 4 
               
               
                   
               
               
                 IPI:IPI00221581.1 
                 T*GSESS*QTGASATSGR{circumflex over ( )} 
                 720 
                 Eif4b 
                 Eukaryotic translation initiation 
                 2.103 
               
               
                   
                   
                   
                   
                 factor 4B 
               
               
                   
               
               
                 IPI:IPI00221581.1 
                 T*GSESS*QTGASATSGR{circumflex over ( )} 
                 721 
                 Eif4b 
                 Eukaryotic translation initiation 
                 2.103 
               
               
                   
                   
                   
                   
                 factor 4B 
               
               
                   
               
               
                 IPI:IPI00221581.1 
                 TGS*ESS*QTGASATSGR 
                 722 
                 Eif4b 
                 Eukaryotic translation initiation 
                 2.103 
               
               
                   
                   
                   
                   
                 factor 4B 
               
               
                   
               
               
                 IPI:IPI00625723.2 
                 TGTGSPFAGNS*PAR{circumflex over ( )}EGE 
                 723 
                 Zc3h4 
                 Isoform 2 of Zinc finger CCCH domain- 
                 2.0988 
               
               
                   
                 QDAGSLK@DVFK@ 
                   
                   
                 containing protein 4 
               
               
                   
               
               
                 IPI:IPI00379844.4 
                 GEQGSLAQSQPQPGDK@N 
                 724 
                 Irs2 
                 Insulin receptor substrate 2 
                 2.0959 
               
               
                   
                 S*WSR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 T*HST*SSS*IGSGESPFSR{circumflex over ( )} 
                 725 
                 Ndrg3 
                 Protein NDRG3 
                 2.0759 
               
               
                   
               
               
                 IPI:IPI00467843.2 
                 GGGAS*SPAPVVFTVGS*PP 
                 726 
                 Ulk1 
                 Putative uncharacterized protein 
                 2.0752 
               
               
                   
                 S*GATPPQSTR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 LK@CGSGPVHISGQHLVAV 
                 727 
                 Npm1 
                 Nucleophosmin 
                 2.0591 
               
               
                   
                 EEDAES*EDEDEEDVK@LL 
               
               
                   
                 GM#SGK@ 
               
               
                   
               
               
                 IPI:IPI00320905.7 
                 LGEQGPEPGPT*PPQTPT*P 
                 728 
                 Arhgap17 
                 Isoform 1 of Rho GTPase-activating 
                 2.0572 
               
               
                   
                 PS*TPPLAK 
                   
                   
                 protein 17 
               
               
                   
               
               
                 IPI:IPI00622946.2 
                 QFIAAQNLGPASGLPTPTSS 
                 729 
                 Palld 
                 Isoform 4 of Palladin 
                 2.0517 
               
               
                   
                 *PSSSSLPSPLSPT*PR{circumflex over ( )}PFG 
               
               
                   
                 R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00467843.2 
                 GGGASS*PAPVVFTVGS*PP 
                 730 
                 Ulk1 
                 Putative uncharacterized protein 
                 2.0359 
               
               
                   
                 S*GATPPOSTR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 TASISSSPS*EGTPAVGSYG 
                 731 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 2.0315 
               
               
                   
                 CT*PQSLPK@ 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 ST*S*PIIGS*PPVR{circumflex over ( )} 
                 732 
                 Patl1 
                 Protein PAT1 homolog 1 
                 2.0311 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 TASIS*SSPS*EGTPAVGSY 
                 733 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 2.0277 
               
               
                   
                 GCT*PQS*LPK@ 
               
               
                   
               
               
                 IPI:IPI00107958.1 
                 TSDIFGS*PVTATAPLAHPN 
                 734 
                 Hn1l 
                 Hematological and neurological 
                 2.0059 
               
               
                   
                 KPK 
                   
                   
                 expressed 1-like protein 
               
               
                   
               
               
                 IPI:IPI00336713.1 
                 CS*PVPGLSSS*PSGSPLHG 
                 735 
                 Bcas3 
                 Isoform 1 of Breast carcinoma- 
                 1.9848 
               
               
                   
                 K@ 
                   
                   
                 amplified sequence 3 homolog 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THST*SSS*IGSGESPFSR{circumflex over ( )} 
                 736 
                 Ndrg3 
                 Protein NDRG3 
                 1.9707 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THSTSS*S*IGSGESPFSR{circumflex over ( )} 
                 737 
                 Ndrg3 
                 Protein NDRG3 
                 1.9707 
               
               
                   
               
               
                 IPI:IPI00830210.1 
                 LSESPAS*LPSCLPVETALIN 
                 738 
                 Atg2a 
                 Autophagy-related protein 2 
                 1.9651 
               
               
                   
                 QR{circumflex over ( )} 
                   
                   
                 homolog A 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GCSPPK@S*PEK@PPQST 
                 739 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.9354 
               
               
                   
                 SS*ESCPPS*PQPTK@ 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00122594.4 
                 ER{circumflex over ( )}EVS*VSS*VTEEPK@LD 
                 740 
                 Ahctf1 
                 AT-hook-containing transcription 
                 1.9159 
               
               
                   
                 SSQLPLQTGLDVPATPR{circumflex over ( )} 
                   
                   
                 factor 1 
               
               
                   
               
               
                 IPI:IPI00336973.2 
                 GLNLDGTPALSTLGGFS*PA 
                 741 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1.8986 
               
               
                   
                 SKPSS*PR 
               
               
                   
               
               
                 IPI:IPI00336973.2 
                 GLNLDGTPALSTLGGFS*PA 
                 742 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1.896 
               
               
                   
                 SKPSS*PR 
               
               
                   
               
               
                 IPI:IPI00336973.2 
                 GLNLDGTPALSTLGGFS*PA 
                 743 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1.896 
               
               
                   
                 SK@PS*SPR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00336973.2 
                 GLNLDGTPALSTLGGFS*PA 
                 744 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1.896 
               
               
                   
                 S*KPSSPR 
               
               
                   
               
               
                 IPI:IPI00336973.2 
                 GLNLDGTPALSTLGGFSPA 
                 745 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1.896 
               
               
                   
                 S*K@PS*SPR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00137166.1 
                 SR{circumflex over ( )}DAT*PPVS*PINMEDQE 
                 746 
                 Junb 
                 Transcription factor jun-B 
                 1.8916 
               
               
                   
                 R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00336973.2 
                 GLNLDGTPALSTLGGFS*PA 
                 747 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1.8893 
               
               
                   
                 S*KPSSPR 
               
               
                   
               
               
                 IPI:IPI00467930.2 
                 LVIGS*LPAHLSPHLFGGFK@ 
                 748 
                 Znrf2 
                 E3 ubiquitin-protein ligase ZNRF2 
                 1.8798 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 R{circumflex over ( )}SSS*ELS*PEVVEK@ 
                 749 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.8718 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 ST*S*PIIGS*PPVR{circumflex over ( )} 
                 750 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.8673 
               
               
                   
               
               
                 IPI:IPI00751009.1 
                 TSEFPTPLFSGPLEPVACGS 
                 751 
                 Srpk2 
                 serine/arginine-rich protein specific 
                 1.859 
               
               
                   
                 VISEGSPLT*EQEESSPSHD 
                   
                   
                 kinase 2 
               
               
                   
                 R{circumflex over ( )}SR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00808277.2 
                 SAPASPNHAGVLSAHSSGA 
                 752 
                 Foxk2 
                 Isoform 1 of Forkhead box protein K2 
                 1.8546 
               
               
                   
                 QT*PES*LSR{circumflex over ( )}EGS*PAPLEP 
               
               
                   
                 EPGASQPK@ 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THS*TSSS*IGSGESPFSR{circumflex over ( )} 
                 753 
                 Ndrg3 
                 Protein NDRG3 
                 1.8482 
               
               
                   
               
               
                 IPI:IPI00761759.1 
                 SSSGSEHST*EGSVSLGDG 
                 754 
                 Larp4 
                 Putative uncharacterized protein 
                 1.8482 
               
               
                   
                 PLSR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00122594.4 
                 EVS*VSS*VTEEPK@LDSSQ 
                 755 
                 Ahctf1 
                 AT-hook-containing transcription 
                 1.8472 
               
               
                   
                 LPLQTGLDVPATPR{circumflex over ( )} 
                   
                   
                 factor 1 
               
               
                   
               
               
                 IPI:IPI00122594.4 
                 EVS*VSS*VTEEPK@LDSSQ 
                 756 
                 Ahctf1 
                 AT-hook-containing transcription 
                 1.8472 
               
               
                   
                 LPLQTGLDVPATPR{circumflex over ( )} 
                   
                   
                 factor 1 
               
               
                   
               
               
                 IPI:IPI00268673.5 
                 AGTTVPES*IHS*FIGDGLVK 
                 757 
                 Mtor 
                 Isoform 1 of FKBP12-rapamycin 
                 1.8442 
               
               
                   
                 @PEALNK@K@ 
                   
                   
                 complex-associated protein 
               
               
                   
               
               
                 IPI:IPI00314502.5 
                 VHGLPTTS*PSGVNMAELA 
                 758 
                 Tcfeb 
                 Transcription factor EB 
                 1.8426 
               
               
                   
                 QQVVK@ 
               
               
                   
               
               
                 IPI:IPI00125319.1 
                 TTS*FAESCK@PVQQPSAF 
                 759 
                 Gsk3b 
                 Glycogen synthase kinase-3 beta 
                 1.8417 
               
               
                   
                 GSMK@ 
               
               
                   
               
               
                 IPI:IPI00125319.1 
                 TTS*FAESCK@PVQQPSAF 
                 760 
                 Gsk3b 
                 Glycogen synthase kinase-3 beta 
                 1.8417 
               
               
                   
                 GSMK@ 
               
               
                   
               
               
                 IPI:IPI00116285.2 
                 SQDSYPVS*PR{circumflex over ( )}PFSSPSMS 
                 761 
                 Ranbp9 
                 RAN binding protein 9 
                 1.8399 
               
               
                   
                 *PSHGMSIHSLAPGK@ 
               
               
                   
               
               
                 IPI:IPI00323510.5 
                 TDNSVAS*SPSSAISTATPS* 
                 762 
                 Kdm6a 
                 Isoform 1 of Lysine-specific 
                 1.8307 
               
               
                   
                 PK@ 
                   
                   
                 demethylase 6A 
               
               
                   
               
               
                 IPI:IPI00229859.1 
                 GHPSAGAEEEGGS*DGS*A 
                 763 
                 Eif3b 
                 Eif3b protein 
                 1.826 
               
               
                   
                 AEAEPR 
               
               
                 PI:IPI00136107.1 
                 THS*TSS*SIGSGESPFSR{circumflex over ( )} 
                 764 
                 Ndrg3 
                 Protein NDRG3 
                 1.8106 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 T*HSTSSSIGS*GESPFSR{circumflex over ( )} 
                 765 
                 Ndrg3 
                 Protein NDRG3 
                 1.8106 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GCS*PPK@S*PEK@PPQST 
                 766 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.8106 
               
               
                   
                 SSESCPPS*PQPTK@ 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00405752.3 
                 VLASS*LS*PYR{circumflex over ( )}EGR{circumflex over ( )} 
                 767 
                 C130092O11Rik 
                 Isoform 1 of Uncharacterized protein 
                 1.8087 
               
               
                   
                   
                   
                   
                 KIAA1680 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THSTSS*S*IGSGESPFSR{circumflex over ( )} 
                 768 
                 Ndrg3 
                 Protein NDRG3 
                 1.8041 
               
               
                   
               
               
                 IPI:IPI00130920.1 
                 RSES*PFEGK 
                 769 
                 Mtap1b 
                 Microtubule-associated protein 1B 
                 1.7981 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THS*TSS*S*IGSGESPFSR{circumflex over ( )} 
                 770 
                 Ndrg3 
                 Protein NDRG3 
                 1.7967 
               
               
                   
               
               
                 IPI:IPI00336713.1 
                 CS*PVPGLSSS*PSGSPLHG 
                 771 
                 Bcas3 
                 Isoform 1 of Breast carcinoma- 
                 1.7932 
               
               
                   
                 K@ 
                   
                   
                 amplified sequence 3 homolog 
               
               
                   
               
               
                 IPI:IPI00323349.2 
                 GYPPPIAAK@PAFGR{circumflex over ( )}PILK 
                 772 
                 Tjp2 
                 Tight junction protein ZO-2 
                 1.7869 
               
               
                   
                 @PST*PVPMPESEEVGES* 
               
               
                   
                 TEEQEDAPR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GCS*PPK@S*PEK@PPQST 
                 773 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.7868 
               
               
                   
                 SSESCPPS*PQPTK@ 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GCS*PPKS*PEKPPQSTSSE 
                 774 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.7868 
               
               
                   
                 SCPPS*PQPTK 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00808277.2 
                 SAPASPNHAGVLSAHSSGA 
                 775 
                 Foxk2 
                 Isoform 1 of Forkhead box protein K2 
                 1.7848 
               
               
                   
                 QT*PES*LSR{circumflex over ( )}EGS*PAPLEP 
               
               
                   
                 EPGASQPK@ 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THS*TSS*S*IGSGESPFSR{circumflex over ( )} 
                 776 
                 Ndrg3 
                 Protein NDRG3 
                 1.7706 
               
               
                   
               
               
                 IPI:IPI00107958.1 
                 TSDIFGS*PVTATAPLAHPN 
                 777 
                 Hn1l 
                 Hematological and neurological 
                 1.7561 
               
               
                   
                 K@PK@ 
                   
                   
                 expressed 1-like protein 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THS*TSSS*IGSGESPFSR{circumflex over ( )} 
                 778 
                 Ndrg3 
                 Protein NDRG3 
                 1.7555 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THS*TSSS*IGSGESPFSR{circumflex over ( )} 
                 779 
                 Ndrg3 
                 Protein NDRG3 
                 1.7525 
               
               
                   
               
               
                 IPI:IPI00130920.1 
                 RSES*PFEGK 
                 780 
                 Mtap1b 
                 Microtubule-associated protein 1B 
                 1.7508 
               
               
                   
               
               
                 IPI:IPI00130920.1 
                 RSES*PFEGK 
                 781 
                 Mtap1b 
                 Microtubule-associated protein 1B 
                 1.7508 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THS*TSS*SIGSGESPFSR{circumflex over ( )} 
                 782 
                 Ndrg3 
                 Protein NDRG3 
                 1.7499 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THS*TSS*SIGSGESPFSR 
                 783 
                 Ndrg3 
                 Protein NDRG3 
                 1.7499 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 784 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.7456 
               
               
                   
                 GGTLFS*TTPGGTRIIYDR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00468516.3 
                 R{circumflex over ( )}LAAQES*SEAEDVTVDR{circumflex over ( )} 
                 785 
                 D6Wsu116e 
                 Isoform 1 of Protein FAM21 
                 1.7446 
               
               
                   
                 GPVAQLSSS*PVLPNGHQP 
               
               
                   
                 LLQPR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00137501.1 
                 TEMDKS*PFNSPS*PQDS*PR 
                 786 
                 Nfic 
                 Isoform 1 of Nuclear factor 1 C-type 
                 1.7419 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GCS*PPK@S*PEK@PPQS* 
                 787 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.7403 
               
               
                   
                 TSSESCPPSPQPTK@ 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GCS*PPK@S*PEK@PPQST 
                 788 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.7403 
               
               
                   
                 SSESCPPS*PQPTK@ 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GCS*PPKS*PEKPPQSTSS* 
                 789 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.7403 
               
               
                   
                 ESCPPSPQPTK 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00336973.2 
                 GLNLDGTPALSTLGGFS*PA 
                 790 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1.7368 
               
               
                   
                 SK@PS*SPR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00107958.1 
                 TSDIFGS*PVTATAPLAHPN 
                 791 
                 Hn1l 
                 Hematological and neurological 
                 1.7353 
               
               
                   
                 K@PK@ 
                   
                   
                 expressed 1-like protein 
               
               
                   
               
               
                 IPI:IPI00227209.3 
                 R{circumflex over ( )}LSS*T*SLASGHSVR{circumflex over ( )} 
                 792 
                 Prkd2 
                 Serine/threonine-protein kinase D2 
                 1.7328 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 RSS*SELS*PEVVEK 
                 793 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.7324 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 R{circumflex over ( )}SS*SELS*PEVVEK@ 
                 794 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.7324 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 RSS*SELS*PEVVEK 
                 795 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.7324 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 R{circumflex over ( )}SSS*ELS*PEVVEK@ 
                 796 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.7324 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00929779.1 
                 S*EGLSQEATPSQDLIQHSC 
                 797 
                 Usp36 
                 Ubiquitin specific peptidase 36 
                 1.7192 
               
               
                   
                 SPVDHSEPEAR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00467930.2 
                 LVIGS*LPAHLS*PHLFGGFK 
                 798 
                 Znrf2 
                 E3 ubiquitin-protein ligase ZNRF2 
                 1.7137 
               
               
                   
               
               
                 IPI:IPI00467930.2 
                 LVIGS*LPAHLS*PHLFG 
                 799 
                 Znrf2 
                 E3 ubiquitin-protein ligase ZNRF2 
                 1.7137 
               
               
                   
                 GFK@ 
               
               
                   
               
               
                 IPI:IPI00459443.5 
                 DLQSEFGVATDSHHSSFGS 
                 800 
                 Tnks1bp1 
                 182 kDa tankyrase-1-binding protein 
                 1.7011 
               
               
                   
                 SSWSQDTSQNYSLGGR{circumflex over ( )}S* 
               
               
                   
                 PVGDTGLGK@ 
               
               
                   
               
               
                 IPI:IPI00785400.1 
                 LTSHTPGLDDEKEAS*ENET 
                 801 
                 Syne2 
                 Syne2 protein 
                 1.7003 
               
               
                   
                 *DIEDPREIQADSWR 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THST*SSSIGSGESPFSR{circumflex over ( )} 
                 802 
                 Ndrg3 
                 Protein NDRG3 
                 1.6838 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THST*SSSIGSGESPFSR{circumflex over ( )} 
                 803 
                 Ndrg3 
                 Protein NDRG3 
                 1.6838 
               
               
                   
               
               
                 IPI:IPI00336713.1 
                 QGGRCS*PVPGLSSS*PSG 
                 804 
                 Bcas3 
                 Isoform 1 of Breast carcinoma- 
                 1.6818 
               
               
                   
                 SPLHGK 
                   
                   
                 amplified sequence 3 homolog 
               
               
                   
               
               
                 IPI:IPI00336713.1 
                 QGGR{circumflex over ( )}CS*PVPGLSS*SPSG 
                 805 
                 Bcas3 
                 Isoform 1 of Breast carcinoma- 
                 1.6818 
               
               
                   
                 SPLHGK@ 
                   
                   
                 amplified sequence 3 homolog 
               
               
                   
               
               
                 IPI:IPI00380354.1 
                 LQES*PKLSQANGTR 
                 806 
                 Llgl1 
                 lethal giant larvae homolog 1 isoform 1 
                 1.6806 
               
               
                   
               
               
                 IPI:IPI00128904.1 
                 VMTIPYQPMPASS*PVICAG 
                 807 
                 Pcbp1 
                 Poly(rC)-binding protein 1 
                 1.6782 
               
               
                   
                 GQDR 
               
               
                   
               
               
                 IPI:IPI00380107.4 
                 LVIPS*ATTKSPPEITVT* 
                 808 
                 Cabin1 
                 calcineurin binding protein 1 
                 1.6782 
               
               
                   
                 PPT*PTLLSPK 
               
               
                   
               
               
                 IPI:IPI00153375.1 
                 SACFS*PVSLS*PR{circumflex over ( )}PCS*PF 
                 809 
                 Pdlim2 
                 PDZ and LIM domain protein 2 
                 1.6659 
               
               
                   
                 STPPPTSPVALSK@ 
               
               
                   
               
               
                 IPI:IPI00467930.2 
                 LVIGS*LPAHLSPHLFGGFK@ 
                 810 
                 Znrf2 
                 E3 ubiquitin-protein ligase ZNRF2 
                 1.6655 
               
               
                   
               
               
                 IPI:IPI00467930.2 
                 LVIGS*LPAHLSPHLFGGFK@ 
                 811 
                 Znrf2 
                 E3 ubiquitin-protein ligase ZNRF2 
                 1.6655 
               
               
                   
               
               
                 IPI:IPI00221581.1 
                 S*R{circumflex over ( )}TGS*ESS*QTGASATS 
                 812 
                 Eif4b 
                 Eukaryotic translation initiation 
                 1.6642 
               
               
                   
                 GR{circumflex over ( )} 
                   
                   
                 factor 4B 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAK@T*PPK@DLPAIP 
                 813 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.6633 
               
               
                   
                 GVTSPTSDEPPMQASQSQL 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 PSSPEDK@ 
               
               
                   
               
               
                 IPI:IPI00120529.2 
                 NK@PLS*PIK@LTPTSVLDY 
                 814 
                 Rfc1 
                 Rfc1 protein 
                 1.6568 
               
               
                   
                 FGTESVQR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 RSS*SELS*PEVVEK 
                 815 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.6324 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 R{circumflex over ( )}SS*SELS*PEVVEK@ 
                 816 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.6324 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 R{circumflex over ( )}SS*SELS*PEVVEK@ 
                 817 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.6324 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 RSS*SELS*PEVVEK 
                 818 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.6324 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 R{circumflex over ( )}SS*SELS*PEVVEK@ 
                 819 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.6324 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 R{circumflex over ( )}SS*SELS*PEVVEK@ 
                 820 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.6324 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00761759.1 
                 SSSGSEHSTEGS*VSLGDG 
                 821 
                 Larp4 
                 Putative uncharacterized protein 
                 1.6294 
               
               
                   
                 PLSR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 R{circumflex over ( )}S*TS*PIIGS*PPVR{circumflex over ( )} 
                 822 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.6275 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 R{circumflex over ( )}S*TS*PIIGS*PPVR{circumflex over ( )} 
                 823 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.6245 
               
               
                   
               
               
                 IPI:IPI00317401.6 
                 AES*PETSAVESTQS*TPQK 
                 824 
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion 
                 1.623 
               
               
                   
                 @GR{circumflex over ( )} 
                   
                   
                 protein PDS5 homolog B 
               
               
                   
               
               
                 IPI:IPI00317401.6 
                 AES*PETSAVESTQST*PQK 
                 825 
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion 
                 1.623 
               
               
                   
                 @GR{circumflex over ( )} 
                   
                   
                 protein PDS5 homolog B 
               
               
                   
               
               
                 IPI:IPI00115620.1 
                 AS*LYNAVTTEDVEK 
                 826 
                 Psat1 
                 Phosphoserine aminotransferase 
                 1.6216 
               
               
                   
               
               
                 IPI:IPI00126124.2 
                 T*FSECS*YPETEEEAEALP 
                 827 
                 St5 
                 Isoform 1 of Suppression of 
                 1.6159 
               
               
                   
                 GR{circumflex over ( )} 
                   
                   
                 tumorigenicity 5 
               
               
                   
               
               
                 IPI:IPI00421179.1 
                 SFS*K@EVEER{circumflex over ( )} 
                 828 
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation 
                 1.6081 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 1 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GCSPPK@S*PEK@PPQST* 
                 829 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.608 
               
               
                   
                 SSESCPPS*PQPTK@ 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00227934.3 
                 AAPSS*EGDS*CDGVEATDA 
                 830 
                 Cux1 
                 cut-like homeobox 1 isoform a 
                 1.6068 
               
               
                   
                 EEPGGNIVATK@ 
               
               
                   
               
               
                 IPI:IPI00314240.5 
                 K@LEK@EEEEGIS*QES*S* 
                 831 
                 Hmga1 
                 Isoform HMG-I of High mobility group 
                 1.6058 
               
               
                   
                 EEEQ 
                   
                   
                 protein HMG-I/HMG-Y 
               
               
                   
               
               
                 IPI:IPI00111754.6 
                 LDT*FCGSPPYAAPELFQGK 
                 832 
                 Mark2 
                 Isoform 2 of Serine/threonine-protein 
                 1.5994 
               
               
                   
                   
                   
                   
                 kinase MARK2 
               
               
                   
               
               
                 IPI:IPI00125319.1 
                 TTS*FAESCK@PVQQPSAF 
                 833 
                 Gsk3b 
                 Glycogen synthase kinase-3 beta 
                 1.5966 
               
               
                   
                 GSMK@ 
               
               
                   
               
               
                 IPI:IPI00320905.7 
                 LGEQGPEPGPT*PPQT*PTP 
                 834 
                 Arhgap17 
                 Isoform 1 of Rho GTPase-activating 
                 1.5946 
               
               
                   
                 PS*TPPLAK 
                   
                   
                 protein 17 
               
               
                   
               
               
                 IPI:IPI00380737.1 
                 TSSVS*S*LASACTGGIPSSS 
                 835 
                 Pom121 
                 Nuclear envelope pore membrane 
                 1.5883 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 protein POM 121 
               
               
                   
               
               
                 IPI:IPI00122594.4 
                 TTPLAS*PSLS*PGR{circumflex over ( )} 
                 836 
                 Ahctf1 
                 AT-hook-containing transcription 
                 1.5845 
               
               
                   
                   
                   
                   
                 factor 1 
               
               
                   
               
               
                 IPI:IPI00125319.1 
                 TTS*FAESCK@PVQQPSAF 
                 837 
                 Gsk3b 
                 Glycogen synthase kinase-3 beta 
                 1.5821 
               
               
                   
                 GSMK@ 
               
               
                   
               
               
                 IPI:IPI00381019.1 
                 KRS*PS*PSPTPEAK 
                 838 
                 Smarcc2 
                 Isoform 2 of SWI/SNF complex subunit 
                 1.5795 
               
               
                   
                   
                   
                   
                 SMARCC2 
               
               
                   
               
               
                 IPI:IPI00111754.6 
                 LDT*FCGSPPYAAPELFQGK@ 
                 839 
                 Mark2 
                 Isoform 2 of Serine/threonine-protein 
                 1.578 
               
               
                   
                   
                   
                   
                 kinase MARK2 
               
               
                   
               
               
                 IPI:IPI00111754.6 
                 LDT*FCGSPPYAAPELFQGK@ 
                 840 
                 Mark2 
                 Isoform 2 of Serine/threonine-protein 
                 1.578 
               
               
                   
                   
                   
                   
                 kinase MARK2 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THS*TSSSIGSGESPFSR{circumflex over ( )} 
                 841 
                 Ndrg3 
                 Protein NDRG3 
                 1.576 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THS*TSSSIGSGESPFSR{circumflex over ( )} 
                 842 
                 Ndrg3 
                 Protein NDRG3 
                 1.576 
               
               
                   
               
               
                 IPI:IPI00128904.1 
                 VMTIPYQPMPASS*PVICAG 
                 843 
                 Pcbp1 
                 Poly(rC)-binding protein 1 
                 1.5752 
               
               
                   
                 GQDR 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 S*SS*PVTELTAR{circumflex over ( )} 
                 844 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.5701 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00421179.1 
                 SFS*KEVEER 
                 845 
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation 
                 1.5642 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 1 
               
               
                   
               
               
                 IPI:IPI00421179.1 
                 SFS*K@EVEER{circumflex over ( )} 
                 846 
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation 
                 1.5642 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 1 
               
               
                   
               
               
                 IPI:IPI00421179.1 
                 SFS*KEVEER 
                 847 
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation 
                 1.5642 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 1 
               
               
                   
               
               
                 IPI:IPI00421179.1 
                 SFS*K@EVEER{circumflex over ( )} 
                 848 
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation 
                 1.5642 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 1 
               
               
                   
               
               
                 IPI:IPI00115492.1 
                 HSLSSESQAPEDIAPPGS*S 
                 849 
                 Eps8l2 
                 Isoform 1 of Epidermal growth factor 
                 1.564 
               
               
                   
                 PHANR{circumflex over ( )} 
                   
                   
                 receptor kinase substrate 8-like 
               
               
                   
                   
                   
                   
                 protein 2 
               
               
                   
               
               
                 IPI:IPI00761759.1 
                 S*SS*GS*EHSTEGSVSLGD 
                 850 
                 Larp4 
                 Putative uncharacterized protein 
                 1.5621 
               
               
                   
                 GPLSR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THSTS*SSIGSGESPFSR{circumflex over ( )} 
                 851 
                 Ndrg3 
                 Protein NDRG3 
                 1.5584 
               
               
                   
               
               
                 IPI:IPI00111754.6 
                 LDT*FCGSPPYAAPELFQGK 
                 852 
                 Mark2 
                 Isoform 2 of Serine/threonine-protein 
                 1.5403 
               
               
                   
                   
                   
                   
                 kinase MARK2 
               
               
                   
               
               
                 IPI:IPI00336973.2 
                 GLNLDGT*PALSTLGGFS*P 
                 853 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1.5363 
               
               
                   
                 ASK@PS*SPR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00229739.4 
                 LVVSS*PTS*PK@GK@ 
                 854 
                 Plekhm1 
                 Pleckstrin homology domain-containing 
                 1.5286 
               
               
                   
                   
                   
                   
                 family M member 1 
               
               
                   
               
               
                 IPI:IPI00126124.2 
                 TFSECS*Y*PETEEEAEALP 
                 855 
                 St5 
                 Isoform 1 of Suppression of 
                 1.526 
               
               
                   
                 GR{circumflex over ( )} 
                   
                   
                 tumorigenicity 5 
               
               
                   
               
               
                 IPI:IPI00122594.4 
                 TTPLAS*PSLS*PGR{circumflex over ( )} 
                 856 
                 Ahctf1 
                 AT-hook-containing transcription 
                 1.5177 
               
               
                   
                   
                   
                   
                 factor 1 
               
               
                   
               
               
                 IPI:IPI00229739.4 
                 LWSS*PTS*PKGK 
                 857 
                 Plekhm1 
                 Pleckstrin homology domain-containing 
                 1.515 
               
               
                   
                   
                   
                   
                 family M member 1 
               
               
                   
               
               
                 IPI:IPI00421179.1 
                 SFS*K@EVEER{circumflex over ( )} 
                 858 
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation 
                 1.5113 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 1 
               
               
                   
               
               
                 IPI:IPI00421179.1 
                 SFS*KEVEER 
                 859 
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation 
                 1.5113 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 1 
               
               
                   
               
               
                 IPI:IPI00349069.4 
                 LFGT*SPAAEVTPSPPEPAP 
                 860 
                 B230208H17Rik 
                 Putative GTP-binding protein Parf 
                 1.5073 
               
               
                   
                 ALEAPAR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00605037.1 
                 KET*ES*EAEDDNLDDLER 
                 861 
                 Srrm1 
                 Isoform 1 of Serine/arginine repetitive 
                 1.5038 
               
               
                   
                   
                   
                   
                 matrix protein 1 
               
               
                   
               
               
                 IPI:IPI00381244.8 
                 KEELGASS*PGYGPPNLGC 
                 862 
                 Mll2 
                 similar to myeloid/lymphoid or mixed- 
                 1.4993 
               
               
                   
                 VDS*PSAGPHLGGLELK 
                   
                   
                 lineage leukemia 2 
               
               
                   
               
               
                 IPI:IPI00421179.1 
                 SFS*K@EVEER{circumflex over ( )} 
                 863 
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation 
                 1.4913 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 1 
               
               
                   
               
               
                 IPI:IPI00421179.1 
                 SFS*KEVEER 
                 864 
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation 
                 1.4913 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 1 
               
               
                   
               
               
                 IPI:IPI00421179.1 
                 SFS*KEVEER 
                 865 
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation 
                 1.4913 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 1 
               
               
                   
               
               
                 IPI:IPI00421179.1 
                 SFS*K@EVEER{circumflex over ( )} 
                 866 
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation 
                 1.4913 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 1 
               
               
                   
               
               
                 IPI:IPI00136572.4 
                 YEENPAWPGTSTHNGPNG 
                 867 
                 Zc3hav1 
                 Isoform 1 of Zinc finger CCCH-type 
                 1.4864 
               
               
                   
                 FSQIMDET*PNVSK@SSPT 
                   
                   
                 antiviral protein 1 
               
               
                   
                 GFGIK@ 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAK@T*PPK@DLPAIP 
                 868 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.4819 
               
               
                   
                 GVTSPTSDEPPMQASQSQL 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 PSSPEDK@ 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAK@T*PPK@DLPAIP 
                 869 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.4819 
               
               
                   
                 GVTSPTSDEPPMQASQSQL 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 PSSPEDK@ 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NSPVAKT*PPKDLPAIPGVT* 
                 870 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.4819 
               
               
                   
                 SPTSDEPPMQASQSQLPSS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 PEDK 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAK@T*PPK@DLPAIP 
                 871 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.4819 
               
               
                   
                 GVTSPTSDEPPMQASQSQL 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 PSSPEDK@ 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGVT 
                 872 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.4819 
               
               
                   
                 SPTSDEPPMQASQSQLPSS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 PEDK 
               
               
                   
               
               
                 IPI:IPI00228948.3 
                 S*FGDK@DLILPNGGTPAG 
                 873 
                 Snx30 
                 Sorting nexin-30 
                 1.4774 
               
               
                   
                 TASPASSSSLLNR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00330246.2 
                 WAAHGTS*PEDFSLTLGAR{circumflex over ( )} 
                 874 
                 Phldb1 
                 Isoform 2 of Pleckstrin homology-like 
                 1.474 
               
               
                   
                   
                   
                   
                 domain family B member 1 
               
               
                   
               
               
                 IPI:IPI00229739.4 
                 LVVSS*PTS*PK@GK@ 
                 875 
                 Plekhm1 
                 Pleckstrin homology domain-containing 
                 1.4728 
               
               
                   
                   
                   
                   
                 family M member 1 
               
               
                   
               
               
                 IPI:IPI00229739.4 
                 LVVSS*PT*SPKGK 
                 876 
                 Plekhm1 
                 Pleckstrin homology domain-containing 
                 1.4728 
               
               
                   
                   
                   
                   
                 family M member 1 
               
               
                   
               
               
                 IPI:IPI00453603.1 
                 FIGS*PR{circumflex over ( )}T*PVS*PVK@FSP 
                 877 
                 Rps6kb1 
                 Isoform Alpha I of Ribosomal protein 
                 1.4727 
               
               
                   
                 GDFWGR{circumflex over ( )} 
                   
                   
                 S6 kinase beta-1 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THS*TSSSIGSGESPFSR{circumflex over ( )} 
                 878 
                 Ndrg3 
                 Protein NDRG3 
                 1.4724 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 THS*TSSSIGSGESPFSR{circumflex over ( )} 
                 879 
                 Ndrg3 
                 Protein NDRG3 
                 1.4724 
               
               
                   
               
               
                 IPI:IPI00317401.6 
                 AES*PETSAVESTQST*PQK 
                 880 
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion 
                 1.4711 
               
               
                   
                 @GR{circumflex over ( )} 
                   
                   
                 protein PDS5 homolog B 
               
               
                   
               
               
                 IPI:IPI00317401.6 
                 AES*PETSAVESTQST*PQK 
                 881 
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion 
                 1.4711 
               
               
                   
                 @GR{circumflex over ( )} 
                   
                   
                 protein PDS5 homolog B 
               
               
                   
               
               
                 IPI:IPI00453603.1 
                 FIGS*PRT*PVS*PVKFSPGD 
                 882 
                 Rps6kb1 
                 Isoform Alpha I of Ribosomal protein 
                 1.4689 
               
               
                   
                 FWGR 
                   
                   
                 S6 kinase beta-1 
               
               
                   
               
               
                 IPI:IPI00453603.1 
                 FIGS*PR{circumflex over ( )}T*PVS*PVK@FSP 
                 883 
                 Rps6kb1 
                 Isoform Alpha I of Ribosomal protein 
                 1.4689 
               
               
                   
                 GDFWGR{circumflex over ( )} 
                   
                   
                 S6 kinase beta-1 
               
               
                   
               
               
                 IPI:IPI00453603.1 
                 FIGS*PR{circumflex over ( )}T*PVS*PVK@FSP 
                 884 
                 Rps6kb1 
                 Isoform Alpha I of Ribosomal protein 
                 1.4689 
               
               
                   
                 GDFWGR{circumflex over ( )} 
                   
                   
                 S6 kinase beta-1 
               
               
                   
               
               
                 IPI:IPI00380737.1 
                 TS*SVSS*LASACTGGIPSSS 
                 885 
                 Pom121 
                 Nuclear envelope pore membrane 
                 1.4684 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 protein POM 121 
               
               
                   
               
               
                 IPI:IPI00380737.1 
                 TS*SVSS*LASACTGGIPSSS 
                 886 
                 Pom121 
                 Nuclear envelope pore membrane 
                 1.4684 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 protein POM 121 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGVT 
                 887 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.4676 
               
               
                   
                 SPTSDEPPMQASQSQLPSS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 PEDK 
               
               
                   
               
               
                 IPI:IPI00317401.6 
                 AES*PETSAVESTQST*PQK 
                 888 
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion 
                 1.4613 
               
               
                   
                 @GR{circumflex over ( )} 
                   
                   
                 protein PDS5 homolog B 
               
               
                   
               
               
                 IPI:IPI00317401.6 
                 AES*PETSAVESTQST*PQK 
                 889 
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion 
                 1.4526 
               
               
                   
                 @GR{circumflex over ( )} 
                   
                   
                 protein PDS5 homolog B 
               
               
                   
               
               
                 IPI:IPI00317401.6 
                 AES*PETSAVESTQST*PQK 
                 890 
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion 
                 1.4526 
               
               
                   
                 @GR{circumflex over ( )} 
                   
                   
                 protein PDS5 homolog B 
               
               
                   
               
               
                 IPI:IPI00136107.1 
                 S*RT*HSTSSSIGSGESPFSR 
                 891 
                 Ndrg3 
                 Protein NDRG3 
                 1.451 
               
               
                   
               
               
                 IPI:IPI00118438.4 
                 KPPAPPSPVQS*QSPS*T*N 
                 892 
                 Srrm1 
                 Isoform 2 of Serine/arginine repetitive 
                 1.45 
               
               
                   
                 WS*PAVPAKK 
                   
                   
                 matrix protein 1 
               
               
                   
               
               
                 IPI:IPI00123410.5 
                 TIS*AQDTLAYATALLNEK@ 
                 893 
                 Usp24 
                 Isoform 1 of Ubiquitin carboxyl- 
                 1.4486 
               
               
                   
                   
                   
                   
                 terminal hydrolase 24 
               
               
                   
               
               
                 IPI:IPI00411026.1 
                 SLHPWYGITPTSS*PK@ 
                 894 
                 Micall1 
                 Isoform 1 of MICAL-like protein 1 
                 1.4479 
               
               
                   
               
               
                 IPI:IPI00761759.1 
                 SSS*GSEHS*T*EGSVSLGD 
                 895 
                 Larp4 
                 Putative uncharacterized protein 
                 1.4347 
               
               
                   
                 GPLSR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00313307.3 
                 SYQNSPS*S*EDGIR{circumflex over ( )}PLPEY 
                 896 
                 Med1 
                 Isoform 4 of Mediator of RNA 
                 1.4214 
               
               
                   
                 STEK@ 
                   
                   
                 polymerase II transcription subunit 1 
               
               
                   
               
               
                 IPI:IPI00313307.3 
                 SYQNS*PSS*EDGIR{circumflex over ( )}PLPEY 
                 897 
                 Med1 
                 Isoform 4 of Mediator of RNA 
                 1.4158 
               
               
                   
                 STEK@ 
                   
                   
                 polymerase II transcription subunit 1 
               
               
                   
               
               
                 IPI:IPI00129264.1 
                 ATSR{circumflex over ( )}PINLGPSS*PNTEIHW 
                 898 
                 Sorbs3 
                 Vinexin 
                 1.4122 
               
               
                   
                 TPYR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 ASYSGTS*PSHS*FISGEPD 
                 899 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.403 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 TR{circumflex over ( )}LAS*ES*ANDDNEDS 
                 900 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 1.3985 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 STS*PIIGS*PPVR{circumflex over ( )} 
                 901 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3955 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 STS*PIIGS*PPVR{circumflex over ( )} 
                 902 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3937 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 STS*PIIGS*PPVR{circumflex over ( )} 
                 903 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3937 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 STS*PIIGS*PPVR 
                 904 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3937 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAK@TPPK@DLPAIP 
                 905 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.3906 
               
               
                   
                 GVTSPTS*DEPPMQASQSQ 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 LPSSPEDK@ 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGVT 
                 906 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.3906 
               
               
                   
                 SPTSDEPPMQASQSQLPSS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 PEDK 
               
               
                   
               
               
                 IPI:IPI00108388.1 
                 R{circumflex over ( )}PYTGNPQYTYNNWS*PP 
                 907 
                 Usp9x 
                 Probable ubiquitin carboxyl-terminal 
                 1.3905 
               
               
                   
                 VQSNETSNGYFLER{circumflex over ( )} 
                   
                   
                 hydrolase FAF-X 
               
               
                   
               
               
                 IPI:IPI00108388.1 
                 RPYTGNPQYTYNNWS*PPV 
                 908 
                 Usp9x 
                 Probable ubiquitin carboxyl-terminal 
                 1.3905 
               
               
                   
                 QSNETSNGYFLER 
                   
                   
                 hydrolase FAF-X 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 STS*PIIGS*PPVR{circumflex over ( )} 
                 909 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3897 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 STS*PIIGS*PPVR{circumflex over ( )} 
                 910 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3897 
               
               
                   
               
               
                 IPI:IPI00556837.1 
                 DTVIIVS*EPS*EDEESHDLP 
                 911 
                 Smarcad1 
                 Isoform 1 of SWI/SNF-related matrix- 
                 1.3868 
               
               
                   
                 SVTR 
                   
                   
                 associated actin-dependent regulator of 
               
               
                   
                   
                   
                   
                 chromatin subfamily A containing 
               
               
                   
                   
                   
                   
                 DEAD/H box 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGVT 
                 912 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.3764 
               
               
                   
                 SPTSDEPPMQASQSQLPSS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 PEDK 
               
               
                   
               
               
                 IPI:IPI00467843.2 
                 GGGASSPAPVVFTVGS*PP 
                 913 
                 Ulk1 
                 Putative uncharacterized protein 
                 1.3745 
               
               
                   
                 SGAT*PPQSTR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00467843.2 
                 GGGASSPAPVVFTVGS*PP 
                 914 
                 Ulk1 
                 Putative uncharacterized protein 
                 1.3745 
               
               
                   
                 SGATPPQST*R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00467843.2 
                 GGGASSPAPVVFTVGS*PP 
                 915 
                 Ulk1 
                 Putative uncharacterized protein 
                 1.3702 
               
               
                   
                 SGAT*PPQSTR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 ASYSGTS*PSHSFISGEPDR{circumflex over ( )} 
                 916 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.3697 
               
               
                   
                   
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 AS*YSGTSPSHSFISGEPDR 
                 917 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.3697 
               
               
                   
                   
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 ASYSGTS*PSHSFISGEPDR{circumflex over ( )} 
                 918 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.3697 
               
               
                   
                   
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00117932.2 
                 SPPVQPHTPVTIS*LGTAPS 
                 919 
                 Sin3a 
                 Isoform 1 of Paired amphipathic helix 
                 1.3566 
               
               
                   
                 LQNNQPVEFNHAINYVNK@ 
                   
                   
                 protein Sin3a 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 STS*PIIGS*PPVR{circumflex over ( )} 
                 920 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3334 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 STS*PIIGS*PPVR{circumflex over ( )} 
                 921 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3334 
               
               
                   
               
               
                 IPI:IPI00224153.6 
                 VHHS*VQTFQEDSLPVAHS* 
                 922 
                 Ptpn21 
                 Tyrosine-protein phosphatase non- 
                 1.3332 
               
               
                   
                 LQEVSEPLTAAR{circumflex over ( )} 
                   
                   
                 receptor type 21 
               
               
                   
               
               
                 IPI:IPI00224153.6 
                 VHHSVQT*FQEDSLPVAHS* 
                 923 
                 Ptpn21 
                 Tyrosine-protein phosphatase non- 
                 1.3332 
               
               
                   
                 LQEVSEPLTAAR 
                   
                   
                 receptor type 21 
               
               
                   
               
               
                 IPI:IPI00136572.4 
                 FHHNS*LEVLSTVS*PLGSG 
                 924 
                 Zc3hav1 
                 Isoform 1 of Zinc finger CCCH-type 
                 1.3312 
               
               
                   
                 PPS*PDVTGCK@DPLEDVS 
                   
                   
                 antiviral protein 1 
               
               
                   
                 ADVTQK@ 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 STS*PIIGS*PPVR 
                 925 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3311 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 STS*PIIGS*PPVR{circumflex over ( )} 
                 926 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3311 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 STS*PIIGS*PPVR{circumflex over ( )} 
                 927 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3311 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 STS*PIIGS*PPVR 
                 928 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3311 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 R{circumflex over ( )}STS*PIIGS*PPVR{circumflex over ( )} 
                 929 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3267 
               
               
                   
               
               
                 IPI:IPI00229739.4 
                 LVVSSPT*S*PK@ 
                 930 
                 Plekhm1 
                 Pleckstrin homology domain-containing 
                 1.3252 
               
               
                   
                   
                   
                   
                 family M member 1 
               
               
                   
               
               
                 IPI:IPI00321774.2 
                 HSSIS*PVR{circumflex over ( )}LPLNSSLGAEL 
                 931 
                 Crkrs 
                 Isoform 2 of Cell division cycle 2- 
                 1.3231 
               
               
                   
                 SR{circumflex over ( )} 
                   
                   
                 related protein kinase 7 
               
               
                   
               
               
                 IPI:IPI00129264.1 
                 ATSR{circumflex over ( )}PINLGPS*SPNTEIHW 
                 932 
                 Sorbs3 
                 Vinexin 
                 1.3226 
               
               
                   
                 TPYR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00380354.1 
                 LQES*PKLSQANGTR 
                 933 
                 Llgl1 
                 lethal giant larvae homolog 1 isoform 1 
                 1.3225 
               
               
                   
               
               
                 IPI:IPI00320905.7 
                 LGEQGPEPGPT*PPQT*PT* 
                 934 
                 Arhgap17 
                 Isoform 1 of Rho GTPase-activating 
                 1.3166 
               
               
                   
                 PPST*PPLAK 
                   
                   
                 protein 17 
               
               
                   
               
               
                 IPI:IPI00381495.5 
                 TVSS*PIPYTPSPS*SSR{circumflex over ( )}PIS 
                 935 
                 Ccdc6 
                 coiled-coil domain containing 6 
                 1.3165 
               
               
                   
                 *PGLSYASHTVGFT*PPTSL 
               
               
                   
                 TR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 ASYSGTS*PSHS*FISGEPD 
                 936 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.3149 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00660767.2 
                 VDTAASSSWLAGS*CS*PVS 
                 937 
                 Ibtk 
                 Isoform 2 of Inhibitor of Bruton 
                 1.3143 
               
               
                   
                 PPVVDLR{circumflex over ( )} 
                   
                   
                 tyrosine kinase 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 RSTS*PIIGS*PPVR 
                 938 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3126 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 R{circumflex over ( )}STS*PIIGS*PPVR{circumflex over ( )} 
                 939 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3126 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 R{circumflex over ( )}STS*PIIGS*PPVR{circumflex over ( )} 
                 940 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3126 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 RSTS*PIIGS*PPVR 
                 941 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3123 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 RSTS*PIIGS*PPVR 
                 942 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3122 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 R{circumflex over ( )}STS*PIIGS*PPVR{circumflex over ( )} 
                 943 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3122 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 R{circumflex over ( )}STS*PIIGS*PPVR{circumflex over ( )} 
                 944 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.3122 
               
               
                   
               
               
                 IPI:IPI00112593.2 
                 S*T*S*S*PK@ 
                 945 
                 Spert 
                 Isoform 2 of Spermatid-associated 
                 1.3085 
               
               
                   
                   
                   
                   
                 protein 
               
               
                   
               
               
                 IPI:IPI00129264.1 
                 ATSR{circumflex over ( )}PINLGPSS*PNTEIHW 
                 946 
                 Sorbs3 
                 Vinexin 
                 1.3056 
               
               
                   
                 TPYR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00129264.1 
                 ATSRPINLGPSS*PNTEIHW 
                 947 
                 Sorbs3 
                 Vinexin 
                 1.3056 
               
               
                   
                 TPYR 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 TR{circumflex over ( )}LAS*ES*ANDDNEDS 
                 948 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 1.3036 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00313307.3 
                 SYQNS*PSS*EDGIRPLPEY 
                 949 
                 Med1 
                 Isoform 4 of Mediator of RNA 
                 1.298 
               
               
                   
                 STEK 
                   
                   
                 polymerase II transcription subunit 1 
               
               
                   
               
               
                 IPI:IPI00313307.3 
                 SYQNS*PSS*EDGIR{circumflex over ( )}PLPEY 
                 950 
                 Med1 
                 Isoform 4 of Mediator of RNA 
                 1.298 
               
               
                   
                 STEK@ 
                   
                   
                 polymerase II transcription subunit 1 
               
               
                   
               
               
                 IPI:IPI00313307.3 
                 SYQNS*PSS*EDGIR{circumflex over ( )}PLPEY 
                 951 
                 Med1 
                 Isoform 4 of Mediator of RNA 
                 1.298 
               
               
                   
                 STEK@ 
                   
                   
                 polymerase II transcription subunit 1 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 ASYSGTS*PSHSFISGEPDR{circumflex over ( )} 
                 952 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.2944 
               
               
                   
                   
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 ASYSGTS*PSHSFISGEPDR 
                 953 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.2944 
               
               
                   
                   
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 ASYSGTS*PSHSFISGEPDR{circumflex over ( )} 
                 954 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.2944 
               
               
                   
                   
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTS*R{circumflex over ( )}PGTPS*AEAASTSS 
                 955 
                 Gtf2f1 
                 General transcription factor IIF 
                 1.2876 
               
               
                   
                 TLR{circumflex over ( )} 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTSRPGT*PS*AEAASTSST 
                 956 
                 Gtf2f1 
                 General transcription factor IIF 
                 1.2876 
               
               
                   
                 LR 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 957 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.2862 
               
               
                   
                 GGTLFS*TTPGGTR{circumflex over ( )}IIYDR{circumflex over ( )} 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 K@ 
               
               
                   
               
               
                 IPI:IPI00221581.1 
                 SR{circumflex over ( )}TGS*ESSQTGASATSG 
                 958 
                 Eif4b 
                 Eukaryotic translation initiation 
                 1.2845 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 factor 4B 
               
               
                   
               
               
                 IPI:IPI00454104.1 
                 TTEAPCSPGS*QQPPS*PDE 
                 959 
                 Scrib 
                 Isoform 1 of Protein LAP4 
                 1.2842 
               
               
                   
                 LPANVK@ 
               
               
                   
               
               
                 IPI:IPI00454104.1 
                 TTEAPCS*PGSQQPPS*PDE 
                 960 
                 Scrib 
                 Isoform 1 of Protein LAP4 
                 1.2842 
               
               
                   
                 LPANVK 
               
               
                   
               
               
                 IPI:IPI00454104.1 
                 TTEAPCS*PGSQQPPS*PDE 
                 961 
                 Scrib 
                 Isoform 1 of Protein LAP4 
                 1.2842 
               
               
                   
                 LPANVK 
               
               
                   
               
               
                 IPI:IPI00320905.7 
                 LGEQGPEPGPTPPQT*PT*P 
                 962 
                 Arhgap17 
                 Isoform 1 of Rho GTPase-activating 
                 1.2828 
               
               
                   
                 PST*PPLAK@ 
                   
                   
                 protein 17 
               
               
                   
               
               
                 IPI:IPI00381495.5 
                 TVSS*PIPYTPS*PSSSR{circumflex over ( )}PIS 
                 963 
                 Ccdc6 
                 coiled-coil domain containing 6 
                 1.2808 
               
               
                   
                 *PGLSYASHTVGFTPPTS*L 
               
               
                   
                 TR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00381495.5 
                 TVSS*PIPYTPS*PSS*SR 
                 964 
                 Ccdc6 
                 coiled-coil domain containing 6 
                 1.2808 
               
               
                   
                 PISPGLSYASHTVGFT* 
               
               
                   
                 PPTSLTR 
               
               
                   
               
               
                 IPI:IPI00381495.5 
                 TVSS*PIPYTPS*PSSSRPIS 
                 965 
                 Ccdc6 
                 coiled-coil domain containing 6 
                 1.2808 
               
               
                   
                 PGLS*YASHTVGFT*PPTSL 
               
               
                   
                 TR 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 RSTS*PIIGS*PPVR 
                 966 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.2745 
               
               
                   
               
               
                 IPI:IPI00336973.2 
                 GLNLDGT*PALSTLGGFS*P 
                 967 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1.273 
               
               
                   
                 ASK@PS*SPR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00336973.2 
                 GLNLDGT*PALSTLGGFS*P 
                 968 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1.273 
               
               
                   
                 ASKPSS*PR 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 R{circumflex over ( )}STS*PIIGS*PPVR{circumflex over ( )} 
                 969 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.2725 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 R{circumflex over ( )}STS*PIIGS*PPVR{circumflex over ( )} 
                 970 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.2725 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 RSTS*PIIGS*PPVR 
                 971 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.2725 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 R{circumflex over ( )}STS*PIIGS*PPVR{circumflex over ( )} 
                 972 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.2723 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 RSTS*PIIGS*PPVR 
                 973 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.2723 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 R{circumflex over ( )}STS*PIIGS*PPVR{circumflex over ( )} 
                 974 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.2723 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 RSTS*PIIGS*PPVR 
                 975 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1.2723 
               
               
                   
               
               
                 IPI:IPI00129264.1 
                 ATSR{circumflex over ( )}PINLGPS*SPNTEIHW 
                 976 
                 Sorbs3 
                 Vinexin 
                 1.2719 
               
               
                   
                 TPYR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAK@T*PPK@DLPAIP 
                 977 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.2719 
               
               
                   
                 GVTSPTSDEPPM#QASQSQ 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 LPSSPEDK@ 
               
               
                   
               
               
                 IPI:IPI00115492.1 
                 HSLSSESQAPEDIAPPGS*S 
                 978 
                 Eps8l2 
                 Isoform 1 of Epidermal growth factor 
                 1.2678 
               
               
                   
                 PHANR{circumflex over ( )} 
                   
                   
                 receptor kinase substrate 8-like 
               
               
                   
                   
                   
                   
                 protein 2 
               
               
                   
               
               
                 IPI:IPI00381495.5 
                 TVSS*PIPYTPS*PSSSR{circumflex over ( )}PIS 
                 979 
                 Ccdc6 
                 coiled-coil domain containing 6 
                 1.2638 
               
               
                   
                 *PGLSYASHTVGFT*PPTSL 
               
               
                   
                 TR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00381495.5 
                 TVSS*PIPYTPS*PSSSRP 
                 980 
                 Ccdc6 
                 coiled-coil domain containing 6 
                 1.2638 
               
               
                   
                 IS*PGLSYASHTVGFT* 
               
               
                   
                 PPTSLTR 
               
               
                   
               
               
                 IPI:IPI00381495.5 
                 TVSS*PIPYTPS*PSSSRP 
                 981 
                 Ccdc6 
                 coiled-coil domain containing 6 
                 1.2638 
               
               
                   
                 IS*PGLSYASHTVGFT* 
               
               
                   
                 PPTSLTR 
               
               
                   
               
               
                 IPI:IPI00381495.5 
                 TVSS*PIPYTPSPSS*SR{circumflex over ( )}PIS 
                 982 
                 Ccdc6 
                 coiled-coil domain containing 6 
                 1.2638 
               
               
                   
                 PGLSYAS*HTVGFTPPTS*L 
               
               
                   
                 TR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00133917.1 
                 YAQGFLPEK@PPQQDHTT* 
                 983 
                 Phc2 
                 Isoform 1 of Polyhomeotic-like 
                 1.2624 
               
               
                   
                 TTDSEMEEPYLQESK@EE 
                   
                   
                 protein 2 
               
               
                   
                 GTPLK@ 
               
               
                   
               
               
                 IPI:IPI00227209.3 
                 R{circumflex over ( )}LS*S*TSLASGHSVR{circumflex over ( )} 
                 984 
                 Prkd2 
                 Serine/threonine-protein kinase D2 
                 1.2605 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 985 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.2599 
               
               
                   
                 GGTLFST*TPGGTR{circumflex over ( )} 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00230368.1 
                 SSS*LGNS*PDR{circumflex over ( )}GPLR{circumflex over ( )}PF 
                 986 
                 2610110G12Rik 
                 Isoform 1 of UPF0635 protein C6orf134 
                 1.2571 
               
               
                   
                 VPEQELLR{circumflex over ( )} 
                   
                   
                 homolog 
               
               
                   
               
               
                 IPI:IPI00845596.1 
                 LFS*QGQDVSDK@VK@ 
                 987 
                 Mllt4 
                 Isoform 3 of Afadin 
                 1.2551 
               
               
                   
               
               
                 IPI:IPI00378026.4 
                 VSSPSCDS*QGLHPEEAPS* 
                 988 
                 Nacc1 
                 Nucleus accumbens-associated protein 1 
                 1.253 
               
               
                   
                 SEPQSPVAQTLGWPACSTP 
               
               
                   
                 LPLVSR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00458460.1 
                 SLS*ESS*VVMDR{circumflex over ( )} 
                 989 
                 Zfp106 
                 Isoform 1 of Zinc finger protein 106 
                 1.2522 
               
               
                   
               
               
                 IPI:IPI00399440.2 
                 HLEDAGST*PS*IGENDLK@ 
                 990 
                 Rictor 
                 Isoform 1 of Rapamycin-insensitive 
                 1.2463 
               
               
                   
                 FPK@ 
                   
                   
                 companion of mTOR 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 TVAISDAAQLPQDYCTT*PG 
                 991 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 1.2423 
               
               
                   
                 GTLFSTT*PGGTR{circumflex over ( )}IIYDR{circumflex over ( )}K@ 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 TVAISDAAQLPQDYCTT*PG 
                 992 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 1.2423 
               
               
                   
                 GTLFST*TPGGTRIIYDRK 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00379682.1 
                 R{circumflex over ( )}ANTLS*HFPVECPAPPEP 
                 993 
                 Tbc1d1 
                 Isoform 1 of TBC1 domain family 
                 1.2355 
               
               
                   
                 AQS*SPGVSQR{circumflex over ( )} 
                   
                   
                 member 1 
               
               
                   
               
               
                 IPI:IPI00454104.1 
                 TTEAPCS*PGSQQPPS*PDE 
                 994 
                 Scrib 
                 Isoform 1 of Protein LAP4 
                 1.2352 
               
               
                   
                 LPANVK 
               
               
                   
               
               
                 IPI:IPI00454104.1 
                 TTEAPCS*PGSQQPPS*PDE 
                 995 
                 Scrib 
                 Isoform 1 of Protein LAP4 
                 1.2352 
               
               
                   
                 LPANVK@ 
               
               
                   
               
               
                 IPI:IPI00454104.1 
                 TTEAPCS*PGSQQPPS*PDE 
                 996 
                 Scrib 
                 Isoform 1 of Protein LAP4 
                 1.2352 
               
               
                   
                 LPANVK@ 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 TVAISDAAQLPQDYCT*TPG 
                 997 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 1.2336 
               
               
                   
                 GTLFSTT*PGGTR{circumflex over ( )}IIYDR{circumflex over ( )}K@ 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00378438.6 
                 S*QSVPGAWPGASPLSSQP 
                 998 
                 Tns1 
                 tensin 1 
                 1.2303 
               
               
                   
                 LLGSS*R{circumflex over ( )}QSHPLTQSR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00118143.1 
                 KQT*PPAS*PS*PQPIEDRPP 
                 999 
                 Cttn 
                 Src substrate cortactin 
                 1.2254 
               
               
                   
                 SS*PIYEDAAPFKAEPSYR 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 ASYSGTSPS*HSFISGEPDR{circumflex over ( )} 
                 1000 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.2251 
               
               
                   
                   
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 ASYSGTS*PSHSFISGEPDR{circumflex over ( )} 
                 1001 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.2251 
               
               
                   
                   
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00127071.3 
                 GATEEEQQDS*GS*EPR{circumflex over ( )}G 
                 1002 
                 Ddx41 
                 Probable ATP-dependent RNA helicase 
                 1.223 
               
               
                   
                 DEDDIPLGPQSNVSLLDQH 
                   
                   
                 DDX41 
               
               
                   
                 QHLK@ 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTSR{circumflex over ( )}PGT*PS*AEAASTSS 
                 1003 
                 Gtf2f1 
                 General transcription factor IIF 
                 1.2226 
               
               
                   
                 TLR{circumflex over ( )} 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTS*R{circumflex over ( )}PGT*PSAEAASTSS 
                 1004 
                 Gtf2f1 
                 General transcription factor IIF 
                 1.2226 
               
               
                   
                 TLR{circumflex over ( )} 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTS*RPGT*PSAEAASTSST 
                 1005 
                 Gtf2f1 
                 General transcription factor IIF 
                 1.2226 
               
               
                   
                 LR 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00117277.2 
                 R{circumflex over ( )}GS*GDTSISMDTEASIR{circumflex over ( )} 
                 1006 
                 Lrrfip1 
                 Isoform 2 of Leucine-rich repeat 
                 1.2213 
               
               
                   
                   
                   
                   
                 flightless-interacting protein 1 
               
               
                   
               
               
                 IPI:IPI00661508.3 
                 LYSLLGIDLTAPSNNS*SPR{circumflex over ( )} 
                 1007 
                 Sbno1 
                 Isoform 2 of Protein strawberry notch 
                 1.2147 
               
               
                   
                 DS*PCK@ENK@ 
                   
                   
                 homolog 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGVT 
                 1008 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.2095 
               
               
                   
                 *SPTSDEPPMQASQSQLPS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 S*PEDK 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 TRLAS*ES*ANDDNEDS 
                 1009 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma derived growth 
                 1.1963 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 TRLAS*ES*ANDDNEDS 
                 1010 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 1.1963 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00929761.1 
                 R{circumflex over ( )}CPS*QSSSR{circumflex over ( )}PATGISQP 
                 1011 
                 Larp1 
                 Isoform 2 of La-related protein 1 
                 1.1959 
               
               
                   
                 PTTPTGQATR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00320905.7 
                 LGEQGPEPGPT*PPQT*PT* 
                 1012 
                 Arhgap17 
                 Isoform 1 of Rho GTPase-activating 
                 1.1918 
               
               
                   
                 PPS*TPPLAK@ 
                   
                   
                 protein 17 
               
               
                   
               
               
                 IPI:IPI00420509.2 
                 S*IEDLQPPNALSAPFTNS 
                 1013 
                 Fmnl3 
                 Isoform 1 of Formin-like protein 3 
                 1.1892 
               
               
                   
                 LAR 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTS*RPGT*PSAEAASTSST 
                 1014 
                 Gtf2f1 
                 General transcription factor IIF 
                 1.1888 
               
               
                   
                   
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GT*SR{circumflex over ( )}PGT*PSAEAASTSS 
                 1015 
                 Gtf2f1 
                 General transcription factor IIF 
                 1.1888 
               
               
                   
                 TLR{circumflex over ( )} 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTS*RPGT*PSAEAASTSST 
                 1016 
                 Gtf2f1 
                 General transcription factor IIF 
                 1.1888 
               
               
                   
                 LR 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTS*R{circumflex over ( )}PGTPS*AEAASTSS 
                 1017 
                 Gtf2f1 
                 General transcription factor IIF 
                 1.1888 
               
               
                   
                 TLR{circumflex over ( )} 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00320905.7 
                 LGEQGPEPGPT*PPQT*PT* 
                 1018 
                 Arhgap17 
                 Isoform 1 of Rho GTPase-activating 
                 1.1882 
               
               
                   
                 PPST*PPLAK 
                   
                   
                 protein 17 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 ASYSGTS*PSHSFISGEPDR 
                 1019 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.1879 
               
               
                   
                   
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 ASYSGTSPS*HSFISGEPDR{circumflex over ( )} 
                 1020 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.1879 
               
               
                   
                   
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 ASYSGTS*PSHSFISGEPDR{circumflex over ( )} 
                 1021 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.1879 
               
               
                   
                   
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 SDELLGDLTRT*PPSSSAAF 
                 1022 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.185 
               
               
                   
                 LK 
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 SDELLGDLTR{circumflex over ( )}T*PPSSSAA 
                 1023 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.185 
               
               
                   
                 FLK@ 
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00340860.5 
                 TAS*EGS*EAETPEAPK@Q 
                 1024 
                 Larp7 
                 Isoform 1 of La-related protein 7 
                 1.1845 
               
               
                   
                 PAK@K@ 
               
               
                   
               
               
                 IPI:IPI00340860.5 
                 TAS*EGS*EAETPEAPK@Q 
                 1025 
                 Larp7 
                 Isoform 1 of La-related protein 7 
                 1.1845 
               
               
                   
                 PAK@K@ 
               
               
                   
               
               
                 IPI:IPI00129264.1 
                 ATSRPINLGPSS*PNTEIHW 
                 1026 
                 Sorbs3 
                 Vinexin 
                 1.175 
               
               
                   
                 TPYR 
               
               
                   
               
               
                 IPI:IPI00129264.1 
                 ATSR{circumflex over ( )}PINLGPSS*PNTEIHW 
                 1027 
                 Sorbs3 
                 Vinexin 
                 1.175 
               
               
                   
                 TPYR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00129264.1 
                 ATSRPINLGPS*SPNTEIHW 
                 1028 
                 Sorbs3 
                 Vinexin 
                 1.175 
               
               
                   
                 TPYR 
               
               
                   
               
               
                 IPI:IPI00381495.5 
                 T*VSSPIPYTPS*PSSS*R{circumflex over ( )}PI 
                 1029 
                 Ccdc6 
                 coiled-coil domain containing 6 
                 1.1749 
               
               
                   
                 SPGLSYASHTVGFT*PPTSL 
               
               
                   
                 TR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTS*R{circumflex over ( )}PGT*PSAEAASTSS 
                 1030 
                 Gtf2f1 
                 General transcription factor IIF 
                 1.1748 
               
               
                   
                 TLR{circumflex over ( )} 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTS*RPGT*PSAEAASTSST 
                 1031 
                 Gtf2f1 
                 General transcription factor IIF 
                 1.1748 
               
               
                   
                 LR 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTS*R{circumflex over ( )}PGT*PSAEAASTSS 
                 1032 
                 Gtf2f1 
                 General transcription factor IIF 
                 1.1748 
               
               
                   
                 TLR{circumflex over ( )} 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00153986.2 
                 GTS*RPGT*PSAEAASTSST 
                 1033 
                 Gtf2f1 
                 General transcription factor IIF 
                 1.1748 
               
               
                   
                 LR 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 IPI:IPI00136572.4 
                 YEENPAWPGTSTHNGPNG 
                 1034 
                 Zc3hav1 
                 Isoform 1 of Zinc finger CCCH-type 
                 1.1738 
               
               
                   
                 FSQIMDETPNVSK@SS*PT 
                   
                   
                 antiviral protein 1 
               
               
                   
                 GFGIK@ 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GSLS*R{circumflex over ( )}SS*S*PVTELTAR{circumflex over ( )} 
                 1035 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.1701 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00133685.1 
                 S*LPVSVPVWAFK@ 
                 1036 
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
                 1.1669 
               
               
                   
               
               
                 IPI:IPI00133685.1 
                 S*LPVSVPVWAFK@ 
                 1037 
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
                 1.1669 
               
               
                   
               
               
                 IPI:IPI00133685.1 
                 S*LPVSVPVWAFK@ 
                 1038 
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
                 1.1669 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GSLS*RSS*S*PVTELTAR 
                 1039 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.1669 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GSLS*R{circumflex over ( )}SS*S*PVTELTAR{circumflex over ( )} 
                 1040 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.1669 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 S*LPTTVPESPNYR{circumflex over ( )} 
                 1041 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 1.1655 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 S*LPTTVPESPNYR 
                 1042 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 1.1655 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 TRLAS*ES*ANDDNEDS 
                 1043 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 1.1626 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 TR{circumflex over ( )}LAS*ES*ANDDNEDS 
                 1044 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 1.1626 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 TR{circumflex over ( )}LAS*ES*ANDDNEDS 
                 1045 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 1.1626 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00116442.1 
                 TRLAS*ES*ANDDNEDS 
                 1046 
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth 
                 1.1626 
               
               
                   
                   
                   
                   
                 factor-related protein 2 
               
               
                   
               
               
                 IPI:IPI00317599.3 
                 SQEDEEEIST*SPGVSEFVS 
                 1047 
                 Syap1 
                 Synapse-associated protein 1 
                 1.1567 
               
               
                   
                 DAFDTCSLNQEDLRK 
               
               
                   
               
               
                 IPI:IPI00317599.3 
                 SQEDEEEISTS*PGVSEFVS 
                 1048 
                 Syap1 
                 Synapse-associated protein 1 
                 1.1567 
               
               
                   
                 DAFDTCSLNQEDLR{circumflex over ( )}K@ 
               
               
                   
               
               
                 IPI:IPI00317599.3 
                 SQEDEEEISTS*PGVSEFVS 
                 1049 
                 Syap1 
                 Synapse-associated protein 1 
                 1.1567 
               
               
                   
                 DAFDTCSLNQEDLR{circumflex over ( )}K@ 
               
               
                   
               
               
                 IPI:IPI00317599.3 
                 SQEDEEEISTS*PGVSEFVS 
                 1050 
                 Syap1 
                 Synapse-associated protein 1 
                 1.1567 
               
               
                   
                 DAFDTCSLNQEDLRK 
               
               
                   
               
               
                 IPI:IPI00126124.2 
                 T*FSECS*YPETEEEAEALP 
                 1051 
                 St5 
                 Isoform 1 of Suppression of 
                 1.1565 
               
               
                   
                 GR{circumflex over ( )} 
                   
                   
                 tumorigenicity 5 
               
               
                   
               
               
                 IPI:IPI00312600.2 
                 LSSDENSNPDLS*GDENDD 
                 1052 
                 Eed 
                 Isoform 1 of Polycomb protein EED 
                 1.1553 
               
               
                   
                 AVSIESGTNTER{circumflex over ( )}PDTPTNT 
               
               
                   
                 PNAPGR{circumflex over ( )}K@ 
               
               
                   
               
               
                 IPI:IPI00312600.2 
                 LSSDENSNPDLS*GDENDD 
                 1053 
                 Eed 
                 Isoform 1 of Polycomb protein EED 
                 1.1553 
               
               
                   
                 AVSIESGTNTERPDTPTNTP 
               
               
                   
                 NAPGRK 
               
               
                   
               
               
                 IPI:IPI00229990.7 
                 RPPGDVLETFNFLENADDS* 
                 1054 
                 Strn3 
                 Striatin-3 
                 1.1544 
               
               
                   
                 DEEENDMIEGIPEGKDK 
               
               
                   
               
               
                 IPI:IPI00229990.7 
                 R{circumflex over ( )}PPGDVLETFNFLENADDS 
                 1055 
                 Strn3 
                 Striatin-3 
                 1.1544 
               
               
                   
                 *DEEENDMIEGIPEGK@DK@ 
               
               
                   
               
               
                 IPI:IPI00121418.1 
                 DGEGPDNLEPACPLSLPLQ 
                 1056 
                 Rb1 
                 Retinoblastoma-associated protein 
                 1.152 
               
               
                   
                 GNHTAADMYLS*PLRS*PK 
               
               
                   
               
               
                 IPI:IPI00121418.1 
                 DGEGPDNLEPACPLSLPLQ 
                 1057 
                 Rb1 
                 Retinoblastoma-associated protein 
                 1.152 
               
               
                   
                 GNHTAADMYLS*PLR{circumflex over ( )}S*PK@ 
               
               
                   
               
               
                 IPI:IPI00121418.1 
                 DGEGPDNLEPACPLSLPLQ 
                 1058 
                 Rb1 
                 Retinoblastoma-associated protein 
                 1.152 
               
               
                   
                 GNHTAADMYLS*PLR{circumflex over ( )}S*PK@ 
               
               
                   
               
               
                 IPI:IPI00136386.2 
                 GDT*S*ET*ASAT*PAY*R{circumflex over ( )} 
                 1059 
                 Tssk4 
                 Isoform 2 of Testis-specific 
                 1.15 
               
               
                   
                   
                   
                   
                 serine/threonine-protein kinase 4 
               
               
                   
               
               
                 IPI:IPI00515576.5 
                 TGVNENTVVSAGKDLSTS*P 
                 1060 
                 Ehbp1 
                 Isoform 2 of EH domain-binding 
                 1.1492 
               
               
                   
                 KPS*PIPS*PVLGQKPNASQ 
                   
                   
                 protein 1 
               
               
                   
                 SLLAWCR 
               
               
                   
               
               
                 IPI:IPI00420143.1 
                 STSSVDSDILSSSHS*S*DTL 
                 1061 
                 Usp47 
                 Isoform 2 of Ubiquitin carboxyl- 
                 1.1474 
               
               
                   
                 CNADSAQIPLANGLDSHSIT 
                   
                   
                 terminal hydrolase 47 
               
               
                   
                 SSR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 TVAISDAAQLPQDYCTT*PG 
                 1062 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 1.147 
               
               
                   
                 GTLFSTT*PGGTRIIYDRK 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 TVAISDAAQLPQDYCT*TPG 
                 1063 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 1.147 
               
               
                   
                 GTLFSTT*PGGTR{circumflex over ( )}IIYDR{circumflex over ( )}K@ 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 SDELLGDLTR{circumflex over ( )}T*PPSSSAA 
                 1064 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.1466 
               
               
                   
                 FLK@ 
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 SDELLGDLTRT*PPSSSAAF 
                 1065 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.1466 
               
               
                   
                 LK 
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00229697.3 
                 GT*FSDQELDAQS*LDDEDD 
                 1066 
                 — 
                 68 kDa protein 
                 1.1465 
               
               
                   
                 SLQHAVHPALNRFS*PS*PR 
               
               
                   
               
               
                 IPI:IPI00133685.1 
                 S*LPVSVPVWAFK@ 
                 1067 
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
                 1.1417 
               
               
                   
               
               
                 IPI:IPI00133685.1 
                 S*LPVSVPVWAFK 
                 1068 
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
                 1.1417 
               
               
                   
               
               
                 IPI:IPI00133685.1 
                 S*LPVSVPVWAFK@ 
                 1069 
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
                 1.1417 
               
               
                   
               
               
                 IPI:IPI00133685.1 
                 S*LPVSVPVWAFK 
                 1070 
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
                 1.1417 
               
               
                   
               
               
                 IPI:IPI00130920.1 
                 SLMSS*PEDLTK@DFEELK 
                 1071 
                 Mtap1b 
                 Microtubule-associated protein 1B 
                 1.1401 
               
               
                   
                 @AEEIDVAK@ 
               
               
                   
               
               
                 IPI:IPI00130920.1 
                 SLMSSPEDLT*KDFEELKAE 
                 1072 
                 Mtap1b 
                 Microtubule-associated protein 1B 
                 1.1401 
               
               
                   
                 EIDVAK 
               
               
                   
               
               
                 IPI:IPI00828355.1 
                 GTLVHTT*SDSDS*EDGDQE 
                 1073 
                 Fmn1 
                 Isoform 5 of Formin-1 
                 1.1401 
               
               
                   
                 AEEESSLDTQK@PTTVVLC 
               
               
                   
                 EPSQEPK@ 
               
               
                   
               
               
                 IPI:IPI00381495.5 
                 T*VSSPIPYTPSPS*SSR{circumflex over ( )}PIS 
                 1074 
                 Ccdc6 
                 coiled-coil domain containing 6 
                 1.1376 
               
               
                   
                 PGLSYASHT*VGFT*PPTSL 
               
               
                   
                 TR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00929761.1 
                 CPS*QSSSRPATGISQPPTT 
                 1075 
                 Larp1 
                 Isoform 2 of La-related protein 1 
                 1.1372 
               
               
                   
                 PTGQATR 
               
               
                   
               
               
                 IPI:IPI00379682.1 
                 R{circumflex over ( )}ANTLS*HFPVECPAPPEP 
                 1076 
                 Tbc1d1 
                 Isoform 1 of TBC1 domain family 
                 1.1351 
               
               
                   
                 AQSS*PGVSQR{circumflex over ( )} 
                   
                   
                 member 1 
               
               
                   
               
               
                 IPI:IPI00379682.1 
                 RANT*LSHFPVECPAPPEPA 
                 1077 
                 Tbc1d1 
                 Isoform 1 of TBC1 domain family 
                 1.1351 
               
               
                   
                 QSS*PGVSQR 
                   
                   
                 member 1 
               
               
                   
               
               
                 IPI:IPI00381495.5 
                 T*VSSPIPYTPSPSS*SR{circumflex over ( )}PIS 
                 1078 
                 Ccdc6 
                 coiled-coil domain containing 6 
                 1.1342 
               
               
                   
                 PGLS*YASHTVGFT*PPTSL 
               
               
                   
                 TR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00381495.5 
                 T*VSSPIPYTPS*PSSSRPIS 
                 1079 
                 Ccdc6 
                 coiled-coil domain containing 6 
                 1.1342 
               
               
                   
                 PGLSYASHT*VGFT*PPTSL 
               
               
                   
                 TR 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 M#SCFS*R{circumflex over ( )}PSMS*PTPLDR{circumflex over ( )} 
                 1080 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.1322 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00133374.5 
                 EVDPSTGELQS*LQMPES*E 
                 1081 
                 Sqstm1 
                 Isoform 1 of Sequestosome-1 
                 1.1315 
               
               
                   
                 GPS*SLDPSQEGPTGLK@ 
               
               
                   
               
               
                 IPI:IPI00133374.5 
                 EVDPSTGELQS*LQMPES*E 
                 1082 
                 Sqstm1 
                 Isoform 1 of Sequestosome-1 
                 1.1315 
               
               
                   
                 GPS*SLDPSQEGPTGLK@ 
               
               
                   
               
               
                 IPI:IPI00133374.5 
                 EVDPSTGELQS*LQMPES*E 
                 1083 
                 Sqstm1 
                 Isoform 1 of Sequestosome-1 
                 1.1315 
               
               
                   
                 GPS*SLDPSQEGPTGLK@ 
               
               
                   
               
               
                 IPI:IPI00133374.5 
                 EVDPSTGELQS*LQMPES*E 
                 1084 
                 Sqstm1 
                 Isoform 1 of Sequestosome-1 
                 1.1315 
               
               
                   
                 GPS*SLDPSQEGPTGLK 
               
               
                   
               
               
                 IPI:IPI00465879.2 
                 LCS*SSS*SDTSPR{circumflex over ( )} 
                 1085 
                 Zc3hc1 
                 Isoform 1 of Nuclear-interacting 
                 1.1277 
               
               
                   
                   
                   
                   
                 partner of ALK 
               
               
                   
               
               
                 IPI:IPI00468802.5 
                 YEMACAIADAFNLPSSHLR{circumflex over ( )} 
                 1086 
                 Mat2b 
                 Isoform 1 of Methionine 
                 1.1262 
               
               
                   
                 PITDS*PVIGAQR{circumflex over ( )}PK@ 
                   
                   
                 adenosyltransferase 2 subunit beta 
               
               
                   
               
               
                 IPI:IPI00121251.7 
                 LSTTPS*PTNS*LHEDGVDD 
                 1087 
                 Tox4 
                 TOX high mobility group box family 
                 1.1209 
               
               
                   
                 FR{circumflex over ( )}R{circumflex over ( )} 
                   
                   
                 member 4 
               
               
                   
               
               
                 IPI:IPI00121251.7 
                 LSTTPS*PTNS*LHEDGVDD 
                 1088 
                 Tox4 
                 TOX high mobility group box family 
                 1.1209 
               
               
                   
                 FR{circumflex over ( )}R{circumflex over ( )} 
                   
                   
                 member 4 
               
               
                   
               
               
                 IPI:IPI00121251.7 
                 LSTTPS*PTNS*LHEDGVDD 
                 1089 
                 Tox4 
                 TOX high mobility group box family 
                 1.1209 
               
               
                   
                 FRR 
                   
                   
                 member 4 
               
               
                   
               
               
                 IPI:IPI00127554.1 
                 R{circumflex over ( )}FS*VQEQDWETT*PPK@ 
                 1090 
                 Emg1 
                 Probable ribosome biogenesis protein 
                 1.1179 
               
               
                   
                 K@ 
                   
                   
                 NEP1 
               
               
                   
               
               
                 IPI:IPI00127554.1 
                 RFS*VQEQDWET*TPPKK 
                 1091 
                 Emg1 
                 Probable ribosome biogenesis protein 
                 1.1179 
               
               
                   
                   
                   
                   
                 NEP1 
               
               
                   
               
               
                 IPI:IPI00459443.5 
                 GEGVSQVGPGTPPAPES*P 
                 1092 
                 Tnks1bp1 
                 182 kDa tankyrase-1-binding protein 
                 1.1175 
               
               
                   
                 RKPISGVQGNDPGISLPQR 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 MELGT*PLR{circumflex over ( )}HSGSTS*PYP 
                 1093 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.1138 
               
               
                   
                 K@ 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 MELGT*PLRHSGST*SPYPK 
                 1094 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.1138 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 MELGT*PLR{circumflex over ( )}HSGSTS*PYP 
                 1095 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.1138 
               
               
                   
                 K@ 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00127764.2 
                 EIS*QSR{circumflex over ( )}NPS*VSEHLPDEK@ 
                 1096 
                 Pcm1 
                 Isoform 1 of Pericentriolar material 1 
                 1.1126 
               
               
                   
                   
                   
                   
                 protein 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAK@T*PPK@DLPAIP 
                 1097 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.1074 
               
               
                   
                 GVTSPTSDEPPMQASQSQL 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 PSS*PEDK@ 
               
               
                   
               
               
                 IPI:IPI00116923.2 
                 SGFAR{circumflex over ( )}PGDLEFEDFS*QVI 
                 1098 
                 Trip10 
                 Isoform 3 of Cdc42-interacting 
                 1.1069 
               
               
                   
                 NR{circumflex over ( )}VPSDSSLGT*PDGR{circumflex over ( )}PE 
                   
                   
                 protein 4 
               
               
                   
                 LR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00121335.1 
                 CGS*PSDSSTSEMMEVAVN 
                 1099 
                 LOC100048123; 
                 RAC-beta serine/threonine-protein 
                 1.1028 
               
               
                   
                 K@ 
                   
                 Akt2 
                 kinase 
               
               
                   
               
               
                 IPI:IPI00356608.4 
                 VGS*LT*PPS*SPK@ 
                 1100 
                 Aak1 
                 Isoform 2 of AP2-associated protein 
                 1.1012 
               
               
                   
                   
                   
                   
                 kinase 1 
               
               
                   
               
               
                 IPI:IPI00828461.1 
                 GPPDFS*SDEER{circumflex over ( )}EPT*PVL 
                 1101 
                 Tmpo 
                 thymopoietin isoform delta 
                 1.1001 
               
               
                   
                 GSGASVGR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00381495.5 
                 TVSSPIPYTPS*PS*SSR{circumflex over ( )}PIS 
                 1102 
                 Ccdc6 
                 coiled-coil domain containing 6 
                 1.0993 
               
               
                   
                 PGLSYASHTVGFTPPTSLTR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00381495.5 
                 TVSSPIPYTPS*PSSSRPISP 
                 1103 
                 Ccdc6 
                 coiled-coil domain containing 6 
                 1.0993 
               
               
                   
                 GLSY*ASHTVGFTPPTSLTR 
               
               
                   
               
               
                 IPI:IPI00127554.1 
                 R{circumflex over ( )}FS*VQEQDWETTPPK@K@ 
                 1104 
                 Emg1 
                 Probable ribosome biogenesis protein 
                 1.0981 
               
               
                   
                   
                   
                   
                 NEP1 
               
               
                   
               
               
                 IPI:IPI00127554.1 
                 R{circumflex over ( )}FS*VQEQDWETTPPK@K@ 
                 1105 
                 Emg1 
                 Probable ribosome biogenesis protein 
                 1.0981 
               
               
                   
                   
                   
                   
                 NEP1 
               
               
                   
               
               
                 IPI:IPI00121251.7 
                 LSTT*PSPTNS*LHEDGVDD 
                 1106 
                 Tox4 
                 TOX high mobility group box family 
                 1.0844 
               
               
                   
                 FRR 
                   
                   
                 member 4 
               
               
                   
               
               
                 IPI:IPI00121251.7 
                 LSTTPS*PTNS*LHEDGVDD 
                 1107 
                 Tox4 
                 TOX high mobility group box family 
                 1.0844 
               
               
                   
                 FR{circumflex over ( )}R{circumflex over ( )} 
                   
                   
                 member 4 
               
               
                   
               
               
                 IPI:IPI00121251.7 
                 LSTTPS*PTNS*LHEDGVDD 
                 1108 
                 Tox4 
                 TOX high mobility group box family 
                 1.0844 
               
               
                   
                 FR{circumflex over ( )}R{circumflex over ( )} 
                   
                   
                 member 4 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAK@T*PPK@DLPAIP 
                 1109 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.0842 
               
               
                   
                 GVTSPTSDEPPMQASQSQL 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 PSS*PEDK@ 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGVT 
                 1110 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.0842 
               
               
                   
                 S*PTSDEPPMQASQSQLPS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 SPEDK 
               
               
                   
               
               
                 IPI:IPI00169771.1 
                 S*SASGTHSES*PEK@LQC 
                 1111 
                 BC031781 
                 UPF0667 protein C1orf55 homolog 
                 1.0823 
               
               
                   
                 PVTEPGQGILENTGTEPGE 
               
               
                   
                 TSDK@ECNER{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAK@T*PPK@DLPAIP 
                 1112 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.0778 
               
               
                   
                 GVTSPTSDEPPMQASQSQL 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 PSS*PEDK@ 
               
               
                   
               
               
                 IPI:IPI00127764.2 
                 EISQS*RNPS*VSEHLPDEK 
                 1113 
                 Pcm1 
                 Isoform 1 of Pericentriolar material 1 
                 1.074 
               
               
                   
                   
                   
                   
                 protein 
               
               
                   
               
               
                 IPI:IPI00112597.1 
                 SQSS*EGVSSLSSS*PSNSL 
                 1114 
                   
                   
                 1.0712 
               
               
                   
                 ETQSQSLSR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00112597.1 
                 SQS*SEGVSSLSSS*PSNSL 
                 1115 
                   
                   
                 1.0712 
               
               
                   
                 ETQSQSLSR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 S*RSSSPDS*KMELGTPLR 
                 1116 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 1.0696 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00330773.3 
                 ASYSGTS*PSHS*FISGEPD 
                 1117 
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like 
                 1.0688 
               
               
                   
                 R{circumflex over ( )} 
                   
                   
                 domain family B member 2 
               
               
                   
               
               
                 IPI:IPI00330246.2 
                 WAAHGTS*PEDFSLTLGAR{circumflex over ( )} 
                 1118 
                 Phldb1 
                 Isoform 2 of Pleckstrin homology-like 
                 1.068 
               
               
                   
                   
                   
                   
                 domain family B member 1 
               
               
                   
               
               
                 IPI:IPI00122594.4 
                 NGVSLFNSPK@T*EQPSPV 
                 1119 
                 Ahctf1 
                 AT-hook-containing transcription 
                 1.0661 
               
               
                   
                 VHSFPHPELPEAFVGTPISN 
                   
                   
                 factor 1 
               
               
                   
                 TSQR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00122594.4 
                 NGVSLFNS*PKTEQPSPVV 
                 1120 
                 Ahctf1 
                 AT-hook-containing transcription 
                 1.0661 
               
               
                   
                 HSFPHPELPEAFVGTPISNT 
                   
                   
                 factor 1 
               
               
                   
                 SQR 
               
               
                   
               
               
                 IPI:IPI00122594.4 
                 NGVSLFNSPK@TEQPSPVV 
                 1121 
                 Ahctf1 
                 AT-hook-containing transcription 
                 1.0661 
               
               
                   
                 HS*FPHPELPEAFVGTPISN 
                   
                   
                 factor 1 
               
               
                   
                 TSQR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00121418.1 
                 DGEGPDNLEPACPLSLPLQ 
                 1122 
                 Rb1 
                 Retinoblastoma-associated protein 
                 1.0618 
               
               
                   
                 GNHTAADMYLS*PLR{circumflex over ( )}S*PK@ 
               
               
                   
               
               
                 IPI:IPI00121418.1 
                 DGEGPDNLEPACPLSLPLQ 
                 1123 
                 Rb1 
                 Retinoblastoma-associated protein 
                 1.0618 
               
               
                   
                 GNHTAADMYLS*PLRS*PK 
               
               
                   
               
               
                 IPI:IPI00320905.7 
                 LGEQGPEPGPT*PPQT*PT* 
                 1124 
                 Arhgap17 
                 Isoform 1 of Rho GTPase-activating 
                 1.0618 
               
               
                   
                 PPST*PPLAK 
                   
                   
                 protein 17 
               
               
                   
               
               
                 IPI:IPI00403116.9 
                 NGS*PVPVPDISQEPDGPAL 
                 1125 
                 Ncaph2 
                 Isoform 3 of Condensin-2 complex 
                 1.0598 
               
               
                   
                 S*GGEEDAEDGAEPLEVAL 
                   
                   
                 subunit H2 
               
               
                   
                 EPAEPR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00403116.9 
                 NGS*PVPVPDISQEPDGPAL 
                 1126 
                 Ncaph2 
                 Isoform 3 of Condensin-2 complex 
                 1.0598 
               
               
                   
                 S*GGEEDAEDGAEPLEVAL 
                   
                   
                 subunit H2 
               
               
                   
                 EPAEPR 
               
               
                   
               
               
                 IPI:IPI00403116.9 
                 NGS*PVPVPDIS*QEPDGPA 
                 1127 
                 Ncaph2 
                 Isoform 3 of Condensin-2 complex 
                 1.0598 
               
               
                   
                 LSGGEEDAEDGAEPLEVAL 
                   
                   
                 subunit H2 
               
               
                   
                 EPAEPR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00230237.1 
                 TAVTATNVSAHGSQANS*P 
                 1128 
                 Pbx1 
                 Isoform PBX1b of Pre-B-cell leukemia 
                 1.054 
               
               
                   
                 STPNSAGGY*PSPCYQPDR 
                   
                   
                 transcription factor 1 
               
               
                   
                 {circumflex over ( )}R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00421139.8 
                 SS*SHLDPAATPHSTLQGSS 
                 1129 
                 Dlg5 
                 Putative uncharacterized protein 
                 1.0498 
               
               
                   
                 AGTPEHPSVIDPLMEQDEG 
               
               
                   
                 PGTPPAK@ 
               
               
                   
               
               
                 IPI:IPI00121251.7 
                 LSTTPS*PTNS*LHEDGVDD 
                 1130 
                 Tox4 
                 TOX high mobility group box family 
                 1.0342 
               
               
                   
                 FRR 
                   
                   
                 member 4 
               
               
                   
               
               
                 IPI:IPI00121251.7 
                 LSTTPS*PTNS*LHEDGVDD 
                 1131 
                 Tox4 
                 TOX high mobility group box family 
                 1.0342 
               
               
                   
                 FR{circumflex over ( )}R{circumflex over ( )} 
                   
                   
                 member 4 
               
               
                   
               
               
                 IPI:IPI00121431.4 
                 S*INYSELDQFPSELEK 
                 1132 
                 Hells 
                 Isoform 1 of Lymphocyte specific 
                 1.0332 
               
               
                   
                   
                   
                   
                 helicase 
               
               
                   
               
               
                 IPI:IPI00121431.4 
                 S*INYSELDQFPSELEK@ 
                 1133 
                 Hells 
                 Isoform 1 of Lymphocyte-specific 
                 1.0332 
               
               
                   
                   
                   
                   
                 helicase 
               
               
                   
               
               
                 IPI:IPI00121431.4 
                 S*INYSELDQFPSELEK@ 
                 1134 
                 Hells 
                 Isoform 1 of Lymphocyte-specific 
                 1.0332 
               
               
                   
                   
                   
                   
                 helicase 
               
               
                   
               
               
                 IPI:IPI00454039.3 
                 VGS*EHSLLDPPGK 
                 1135 
                 Erbb2ip 
                 Isoform 1 of Protein LAP2 
                 1.0307 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 TVAISDAAQLPQDYCTT*PG 
                 1136 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 1.0271 
               
               
                   
                 GTLFSTT*PGGTR{circumflex over ( )}IIYDR{circumflex over ( )} 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 TVAISDAAQLPQDYCTT*PG 
                 1137 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 1.0271 
               
               
                   
                 GTLFSTT*PGGTRIIYDR 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00226228.5 
                 ANNAGASIYPTGPADPCPP 
                 1138 
                 Azi1 
                 5-azacytidine-induced protein 1 
                 1.0268 
               
               
                   
                 ASES*S*PEQWQSPEDKPQ 
               
               
                   
                 DIHSQGEAR 
               
               
                   
               
               
                 IPI:IPI00317401.6 
                 AES*PETSAVESTQST*PQK@ 
                 1139 
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion 
                 1.0246 
               
               
                   
                   
                   
                   
                 protein PDS5 homolog B 
               
               
                   
               
               
                 IPI:IPI00317401.6 
                 AES*PETSAVESTQST*PQK@ 
                 1140 
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion 
                 1.0246 
               
               
                   
                   
                   
                   
                 protein PDS5 homolog B 
               
               
                   
               
               
                 IPI:IPI00317401.6 
                 AES*PETSAVESTQST*PQK 
                 1141 
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion 
                 1.0246 
               
               
                   
                   
                   
                   
                 protein PDS5 homolog B 
               
               
                   
               
               
                 IPI:IPI00113389.5 
                 HNLFEDNM#ALPSESVSS*L 
                 1142 
                 Fam129a 
                 Protein Niban 
                 1.0232 
               
               
                   
                 TDLK 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAK@T*PPK@DLPAIP 
                 1143 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.0227 
               
               
                   
                 GVTSPTSDEPPM#QASQSQ 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 LPSSPEDK@ 
               
               
                   
               
               
                 IPI:IPI00463074.6 
                 SRS*S*PSTDHYSQEVPVEP 
                 1144 
                 Shroom2 
                 shroom family member 2 
                 1.0176 
               
               
                   
                 NR 
               
               
                   
               
               
                 IPI:IPI00463074.6 
                 SRS*S*PSTDHYSQEVPVEP 
                 1145 
                 Shroom2 
                 shroom family member 2 
                 1.0176 
               
               
                   
                 NR 
               
               
                   
               
               
                 IPI:IPI00463074.6 
                 SR{circumflex over ( )}S*S*PSTDHYSQEVPVE 
                 1146 
                 Shroom2 
                 shroom family member 2 
                 1.0176 
               
               
                   
                 PNR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 S*NS*FSDERAEFSAPSTPT 
                 1147 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 1.0143 
               
               
                   
                 GTLEFAGGDAK@ 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 S*NS*FSDEREFSAPSTPTG 
                 1148 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 1.0143 
               
               
                   
                 TLEFAGGDAK 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 S*NS*FSDEREFSAPSTPTG 
                 1149 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 1.0143 
               
               
                   
                 TLEFAGGDAK 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGVT 
                 1150 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1.0129 
               
               
                   
                 SPT*SDEPPMQASQSQLPS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 S*PEDK 
               
               
                   
               
               
                 IPI:IPI00127131.6 
                 GPS*PSPVGS*PASVAQSR{circumflex over ( )} 
                 1151 
                 Arid1a 
                 AT rich interactive domain 1A 
                 1.0107 
               
               
                   
               
               
                 IPI:IPI00113389.5 
                 HNLFEDNMALPSES*VSSLT 
                 1152 
                 Fam129a 
                 Protein Niban 
                 1.0048 
               
               
                   
                 DLK@TAMGS*NQAS*PAR{circumflex over ( )} 
               
               
                   
                 R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00113389.5 
                 HNLFEDNMALPSESVSSLT* 
                 1153 
                 Fam129a 
                 Protein Niban 
                 1.0048 
               
               
                   
                 DLK@TAMGS*NQAS*PAR{circumflex over ( )} 
               
               
                   
                 R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00454109.2 
                 FPPST*PSEVLS*PTEDPRS* 
                 1154 
                 Erf 
                 ETS domain-containing transcription 
                 1.0039 
               
               
                   
                 PPACSSSSSSLFSAVVAR 
                   
                   
                 factor ERF 
               
               
                   
               
               
                 IPI:IPI00120095.2 
                 CDGS*PR{circumflex over ( )}T*PPS*TPPATAN 
                 1155 
                 Samhd1 
                 SAM domain and HD domain- 
                 1.0027 
               
               
                   
                 LSADDDFQNTDLR{circumflex over ( )} 
                   
                   
                 containing protein 1 
               
               
                   
               
               
                 IPI:IPI00117229.3 
                 TS*PAGGTWSSVVSGVPR{circumflex over ( )} 
                 1156 
                 Atxn2 
                 ataxin 2 
                 1.0015 
               
               
                   
               
               
                 IPI:IPI00117229.3 
                 TS*PAGGTWSSVVSGVPR 
                 1157 
                 Atxn2 
                 ataxin 2 
                 1.0015 
               
               
                   
               
               
                 IPI:IPI00320594.5 
                 SQDSYPGS*PSLS*PR 
                 1158 
                 Ranbp10 
                 Ran-binding protein 10 
                 1.0009 
               
               
                   
               
               
                 IPI:IPI00320594.5 
                 SQDSYPGS*PSLS*PR{circumflex over ( )} 
                 1159 
                 Ranbp10 
                 Ran-binding protein 10 
                 1.0009 
               
               
                   
               
               
                 IPI:IPI00320594.5 
                 SQDSYPGS*PSLS*PR{circumflex over ( )} 
                 1160 
                 Ranbp10 
                 Ran-binding protein 10 
                 1.0009 
               
               
                   
               
               
                 IPI:IPI00320594.5 
                 SQDS*YPGS*PSLSPR 
                 1161 
                 Ranbp10 
                 Ran-binding protein 10 
                 1.0009 
               
               
                   
               
               
                 IPI:IPI00320594.5 
                 SQDSYPGS*PSLS*PR{circumflex over ( )} 
                 1162 
                 Ranbp10 
                 Ran-binding protein 10 
                 1.0009 
               
               
                   
               
               
                 IPI:IPI00121251.7 
                 LSTTPS*PTNS*LHEDGVDD 
                 1163 
                 Tox4 
                 TOX high mobility group box family 
                 1.0005 
               
               
                   
                 FR{circumflex over ( )}R{circumflex over ( )} 
                   
                   
                 member 4 
               
               
                   
               
               
                 IPI:IPI00121251.7 
                 LSTTPS*PTNS*LHEDGVDD 
                 1164 
                 Tox4 
                 TOX high mobility group box family 
                 1.0005 
               
               
                   
                 FRR 
                   
                   
                 member 4 
               
               
                   
               
               
                 Table 7. Phosphopeptides whose intensities decrease after rapamycin treatment (Rapamycin screen). 
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 8 
               
               
                   
               
               
                   
                   
                   
                   
                   
                 Log2 
               
               
                   
                   
                 SEQ 
                   
                   
                 Area 
               
               
                   
                   
                 ID 
                 Gene 
                   
                 (H/L) 
               
               
                 Reference 
                 Ascore Seq 
                 NO 
                 Name 
                 Annotation 
                 Ratio 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
            
               
                 Ku (light cells: control (rapamycin treated); heavy cells: treated with 
               
               
                 rapamycin + Ku-0063794. L, light; H, heavy) 
               
            
           
           
               
               
               
               
               
               
            
               
                 IPI:IPI00648918.3 
                 DQEEELDEQAGS*IQM#LEQ 
                 1165 
                 Myo18a 
                 Isoform 4 of Myosin-XVIIIa 
                 −7.171 
               
               
                   
                 LK 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1166 
                 Eif4ebp1 
                 Eukaryotic translation 
                 −7.159 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 initiation factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYS*TT*P 
                 1167 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −7.127 
               
               
                   
                 GGTLFSTTPGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00622700.2 
                 TAPPVLPTGYDS*EEEEESR 
                 1168 
                 Brd2 
                 Isoform 2 of Bromodomain-containing 
                 −6.823 
               
               
                   
                 {circumflex over ( )}PMSYDEK@ 
                   
                   
                 protein 2 
               
               
                   
               
               
                 IPI:IPI00458153.2 
                 ENPPSPPT*SPAAPQPR{circumflex over ( )} 
                 1169 
                 6330577E15Rik 
                 Uncharacterized protein C10orf78 
                 −6.819 
               
               
                   
                   
                   
                   
                 homolog 
               
               
                   
               
               
                 IPI:IPI00454090.1 
                 DSVDLQS*LM#TEM#NR 
                 1170 
                 Best3 
                 Bestrophin-3 
                 −6.498 
               
               
                   
               
               
                 IPI:IPI00274140.4 
                 LSPFFTLDLS*PTDDKSSKP 
                 1171 
                 Grit 
                 Isoform 2 of Rho/Cdc42/Rac GTPase- 
                 −6.465 
               
               
                   
                 SSFTEK 
                   
                   
                 activating protein RICS 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 SLPT*TVPES*PNYR 
                 1172 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 −6.159 
               
               
                   
               
               
                 IPI:IPI00224969.2 
                 VAPS*MSSLNS*LAS*S*CFD 
                 1173 
                 Fam62c 
                 Isoform 1 of Extended synaptotagmin-3 
                 −6.023 
               
               
                   
                 LTDVSLNTEAGDSR 
               
               
                   
               
               
                 IPI:IPI00929786.1 
                 S*LPTTVPES*PNYR 
                 1174 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 −5.98 
               
               
                   
               
               
                 IPI:IPI00458039.3 
                 IFTEANLVS*VGS*KK 
                 1175 
                 Mdn1 
                 Midasin homolog 
                 −5.907 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGVT 
                 1176 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −5.874 
               
               
                   
                 SPTSDEPPMQASQSQLPS* 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 SPEDK 
               
               
                   
               
               
                 IPI:IPI00130920.1 
                 TLEVVSPSQSVTGS*AGHTP 
                 1177 
                 Mtap1b 
                 Microtubule-associated protein 1B 
                 −5.86 
               
               
                   
                 YYQS*PTDEK 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1178 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −5.685 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00270767.3 
                 VVK@EDGVMS*PEK@ 
                 1179 
                 Rtn4 
                 Isoform 2 of Reticulon-4 
                 −5.681 
               
               
                   
               
               
                 IPI:IPI00121430.2 
                 DLKPETDYVVNVY*S*VVED 
                 1180 
                 Col12a1 
                 Isoform 1 of Collagen alpha-1(XII) 
                 −5.655 
               
               
                   
                 EYSEPLKGT*EK 
                   
                   
                 chain 
               
               
                   
               
               
                 IPI:IPI00169506.7 
                 QAVY*Y*LTLQAT*DGGNQS 
                 1181 
                 Pcdh24 
                 Pcdh24 protein 
                 −5.499 
               
               
                   
                 TT*TALEITLLDINDNPPVVR 
               
               
                   
               
               
                 IPI:IPI00133685.1 
                 LNT*SDFQK 
                 1182 
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
                 −5.419 
               
               
                   
               
               
                 IPI:IPI00876080.1 
                 LPDLRS*R 
                 1183 
                 Gpr157 
                 Putative uncharacterized protein 
                 −5.334 
               
               
                   
                   
                   
                   
                 (Fragment) 
               
               
                   
               
               
                 IPI:IPI00850983.1 
                 TPGPPS*SQGSPVDTQPAA 
                 1184 
                 Synj1 
                 similar to mKIAA0910 protein 
                 −5.321 
               
               
                   
                 QK 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGVT 
                 1185 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −4.991 
               
               
                   
                 SPTSDEPPMQASQSQLPSS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 *PEDK 
               
               
                   
               
               
                 IPI:IPI00282808.7 
                 T*PGVPKQKPCSPLS*EPDA 
                 1186 
                 Zfp318 
                 zinc finger protein 318 isoform 1 
                 −4.923 
               
               
                   
                 FLK 
               
               
                   
               
               
                 IPI:IPI00133374.5 
                 EVDPSTGELQSLQMPESEG 
                 1187 
                 Sqstm1 
                 Isoform 1 of Sequestosome-1 
                 −4.888 
               
               
                   
                 PS*SLDPSQEGPTGLK@ 
               
               
                   
               
               
                 IPI:IPI00133374.5 
                 EVDPSTGELQSLQMPESEG 
                 1188 
                 Sqstm1 
                 Isoform 1 of Sequestosome-1 
                 −4.882 
               
               
                   
                 PS*SLDPSQEGPTGLK@ 
               
               
                   
               
               
                 IPI:IPI00133685.1 
                 LNT*SDFQK 
                 1189 
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
                 −4.871 
               
               
                   
               
               
                 IPI:IPI00623114.5 
                 DMPAAGS*LGSSS*R 
                 1190 
                 Fat1 
                 FAT tumor suppressor homolog 1 
                 −4.85 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1191 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −4.78 
               
               
                   
                 GGT*LFSTTPGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00125442.4 
                 VPMVSS*QPTS*SM#VPPPI 
                 1192 
                 Alpk3 
                 myocyte induction differentiation 
                 −4.621 
               
               
                   
                 KPLNR 
                   
                   
                 originator 
               
               
                   
               
               
                 IPI:IPI00380641.3 
                 KLPVVSS*VVK 
                 1193 
                 Zc3h14 
                 Isoform 2 of Zinc finger CCCH domain- 
                 −4.368 
               
               
                   
                   
                   
                   
                 containing protein 14 
               
               
                   
               
               
                 IPI:IPI00338745.4 
                 QADVADQQTTELPAENGET 
                 1194 
                 Hmgn1; 
                 Non-histone chromosomal protein 
                 −4.324 
               
               
                   
                 ENQSPAS*EEEKEAK 
                   
                 LOC100044391 
                 HMG-14 
               
               
                   
               
               
                 IPI:IPI00338745.4 
                 QADVADQQTTELPAENGET 
                 1195 
                 Hmgn1; 
                 Non-histone chromosomal protein 
                 −4.324 
               
               
                   
                 ENQS*PASEEEKEAK 
                   
                 LOC100044391 
                 HMG-14 
               
               
                   
               
               
                 IPI:IPI00271998.4 
                 GPNS*PPPGMPLR 
                 1196 
                 2310057M21Rik 
                 Uncharacterized protein C10orf88 
                 −4.316 
               
               
                   
                   
                   
                   
                 homolog 
               
               
                   
               
               
                 IPI:IPI00338976.3 
                 FTISAIS*K 
                 1197 
                 Fcrls 
                 Fc receptor-like protein 2 scavenger 
                 −4.254 
               
               
                   
                   
                   
                   
                 isoform 
               
               
                   
               
               
                 IPI:IPI00352984.4 
                 IVHFS*VNACLT*PICSLHHV 
                 1198 
                 Xdh 
                 Xanthine dehydrogenase/oxidase 
                 −4.21 
               
               
                   
                 AVTT*VEGIGNTKK 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYS*TTP 
                 1199 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −4.196 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00330246.2 
                 K@GSFS*GR{circumflex over ( )}LS*PAYSLGS 
                 1200 
                 Phldb1 
                 Isoform 2 of Pleckstrin homology-like 
                 −4.16 
               
               
                   
                 LTGASPR{circumflex over ( )} 
                   
                   
                 domain family B member 1 
               
               
                   
               
               
                 IPI:IPI00330066.5 
                 T*RSPDVISSASTALSQDIPE 
                 1201 
                 Edc4 
                 Isoform 1 of Enhancer of mRNA- 
                 −4.045 
               
               
                   
                 IASEALSR 
                   
                   
                 decapping protein 4 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 RKETPS*PR 
                 1202 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −4.005 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00405665.6 
                 K@IIETM#SS*PK@ 
                 1203 
                 Kif20b 
                 Isoform 1 of M-phase phosphoprotein 1 
                 −3.928 
               
               
                   
               
               
                 IPI:IPI00311187.4 
                 S*AASGS*SGES*MDSVSVS 
                 1204 
                 Rgl1 
                 Ral guanine nucleotide dissociation 
                 −3.911 
               
               
                   
                 *S*CESNHS*EAEEGPVTPM 
                   
                   
                 stimulator-like 1 
               
               
                   
                 DTPDEPQKK 
               
               
                   
               
               
                 IPI:IPI00153724.1 
                 VHS*PPASLVPR{circumflex over ( )} 
                 1205 
                 1110007A13Rik 
                 UPF0557 protein C10orf119 homolog 
                 −3.905 
               
               
                   
               
               
                 IPI:IPI00121277.1 
                 VAAAAGSGPS*PPCS*PGH 
                 1206 
                 Pi4k2a 
                 Phosphatidylinositol 4-kinase type 2- 
                 −3.904 
               
               
                   
                 DR 
                   
                   
                 alpha 
               
               
                   
               
               
                 IPI:IPI00331556.5 
                 MQVDQEEPHTEEQQQQPQ 
                 1207 
                 Hspa4 
                 Heat shock 70 kDa protein 4 
                 −3.897 
               
               
                   
                 TPAENKAESEEM#ET*SQA 
               
               
                   
                 GSK 
               
               
                   
               
               
                 IPI:IPI00135443.2 
                 KTSFDQDS*DVDIFPSDFTS 
                 1208 
                 Top2b 
                 DNA topoisomerase 2-beta 
                 −3.873 
               
               
                   
                 EPPALPR 
               
               
                   
               
               
                 IPI:IPI00469938.3 
                 VGSGAEPGEGS*PGSR{circumflex over ( )}PG 
                 1209 
                 BC021381 
                 Isoform 2 of Uncharacterized protein 
                 −3.843 
               
               
                   
                 PIQADS*PK@ 
                   
                   
                 KIAA1931 
               
               
                   
               
               
                 IPI:IPI00331361.2 
                 SPT*KAEPATPAEAAQSDR 
                 1210 
                 Mybbp1a 
                 Myb-binding protein 1A 
                 −3.83 
               
               
                   
               
               
                 IPI:IPI00625898.3 
                 RQS*S*ESDIESVMYT 
                 1211 
                 Bbx 
                 Isoform 1 of HMG box transcription 
                 −3.809 
               
               
                   
                 IEAVAK 
                   
                   
                 factor BBX 
               
               
                   
               
               
                 IPI:IPI00405227.3 
                 S*LGEIAALTSK 
                 1212 
                 Vcl 
                 Vinculin 
                 −3.804 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 RNS*PMAQTPPCHLPNIPGV 
                 1213 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 −3.791 
               
               
                   
                 TSPGALIEDSK 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1214 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.751 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDY*STT 
                 1215 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.726 
               
               
                   
                 PGGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTT* 
                 1216 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.726 
               
               
                   
                 PGGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTTPG 
                 1217 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.705 
               
               
                   
                 GTLFS*TT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00929814.1 
                 KEANEVLS*DS*AGEDHPAE 
                 1218 
                 Morc2a 
                 microrchidia 2A isoform 2 
                 −3.673 
               
               
                   
                 LR 
               
               
                   
               
               
                 IPI:IPI00229645.2 
                 S*NDDLLAGMAGGVNVTNG 
                 1219 
                 Cytsa 
                 Cytospin-A 
                 −3.632 
               
               
                   
                 IK 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 AGAIS*ASGPELEGAGHSK 
                 1220 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 −3.608 
               
               
                   
               
               
                 IPI:IPI00756424.3 
                 TAR{circumflex over ( )}PNSEAPLS*GS*EDAD 
                 1221 
                 Eif5b 
                 Isoform 1 of Eukaryotic translation 
                 −3.543 
               
               
                   
                 DSNK@ 
                   
                   
                 initiation factor 5B 
               
               
                   
               
               
                 IPI:IPI00121760.5 
                 LKTEEGEIVY*SAEESENR 
                 1222 
                 Hnrpll 
                 Isoform 1 of Heterogeneous nuclear 
                 −3.51 
               
               
                   
                   
                   
                   
                 ribonucleoprotein L-like 
               
               
                   
               
               
                 IPI:IPI00458958.2 
                 DWDKES*EGEEPAGGR 
                 1223 
                 Rrp15 
                 RRP15-like protein 
                 −3.46 
               
               
                   
               
               
                 IPI:IPI00458958.2 
                 DWDK@ES*EGEEPAGGR{circumflex over ( )} 
                 1224 
                 Rrp15 
                 RRP15-like protein 
                 −3.46 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTT* 
                 1225 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.429 
               
               
                   
                 PGGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTTP 
                 1226 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.429 
               
               
                   
                 GGT*LFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTT* 
                 1227 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.429 
               
               
                   
                 PGGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00109695.3 
                 IEILDS*PASK 
                 1228 
                 D10Wsu102e 
                 Uncharacterized protein C12orf45 
                 −3.403 
               
               
                   
                   
                   
                   
                 homolog 
               
               
                   
               
               
                 IPI:IPI00230719.8 
                 RDS*SDDWEIPDGQITVGQR 
                 1229 
                 Braf 
                 Isoform 1 of B-Raf proto-oncogene 
                 −3.372 
               
               
                   
                   
                   
                   
                 serine/threonine-protein kinase 
               
               
                   
               
               
                 IPI:IPI00377925.2 
                 SS*PVCSTAPVETEPK 
                 1230 
                 Atg2b 
                 Isoform 1 of Autophagy-related protein 
                 −3.353 
               
               
                   
                   
                   
                   
                 2 homolog B 
               
               
                   
               
               
                 IPI:IPI00221723.1 
                 MGQEFVES*K 
                 1231 
                 Wasf2 
                 Wiskott-Aldrich syndrome protein family 
                 −3.314 
               
               
                   
                   
                   
                   
                 member 2 
               
               
                   
               
               
                 IPI:IPI00165794.1 
                 LWTHTSDQQVSAISNPSPC 
                 1232 
                 Tmem48 
                 Nucleoporin NDC1 
                 −3.255 
               
               
                   
                 AS*VTAEGK 
               
               
                   
               
               
                 IPI:IPI00848747.1 
                 DDS*TCLGGILPAGLEPGS* 
                 1233 
                 4930568B11Rik 
                 hypothetical protein LOC75873 
                 −3.253 
               
               
                   
                 S*T*R 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1234 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.239 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 1235 
                 Npm1 
                 Nucleophosmin 
                 −3.232 
               
               
                   
                 AES*EDEDEEDVK@ 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYST*TP 
                 1236 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.209 
               
               
                   
                 GGTLFST*TPGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYS*TTP 
                 1237 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.209 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1238 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.175 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1239 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.175 
               
               
                   
                 GGTLFS*TTPGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00120133.1 
                 EDGDILAS*S*FSVDTQVAYI 
                 1240 
                 Nat15 
                 N-acetyltransferase 15 
                 −3.163 
               
               
                   
                 LSLGVVK 
               
               
                   
               
               
                 IPI:IPI00154109.2 
                 SNS*APLIHGLSDSS*PVFQA 
                 1241 
                 Fam122a 
                 Protein FAM122A 
                 −3.124 
               
               
                   
                 EAPSAR 
               
               
                   
               
               
                 IPI:IPI00138199.5 
                 DGY*Y*GES*T*S*GR{circumflex over ( )} 
                 1242 
                 Pcsk5 
                 proprotein convertase subtilisin/kexin 
                 −3.103 
               
               
                   
                   
                   
                   
                 type 5 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTT* 
                 1243 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.092 
               
               
                   
                 PGGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00130920.1 
                 TELS*PSFINPNPLEWFAGE 
                 1244 
                 Mtap1b 
                 Microtubule-associated protein 1B 
                 −3.089 
               
               
                   
                 EPTEESEKPLTQSGGAPPP 
               
               
                   
                 SGGK 
               
               
                   
               
               
                 IPI:IPI00131725.3 
                 HQIVCINNDLS*EEES*DDES 
                 1245 
                 Npm3 
                 Nucleoplasmin-3 
                 −3.087 
               
               
                   
                 *EEDEIK@LCGILPAK@ 
               
               
                   
               
               
                 IPI:IPI00330066.5 
                 T*RSPDVISSASTALSQDIPE 
                 1246 
                 Edc4 
                 Isoform 1 of Enhancer of mRNA- 
                 −3.084 
               
               
                   
                 IASEALSR 
                   
                   
                 decapping protein 4 
               
               
                   
               
               
                 IPI:IPI00756765.3 
                 ALVIQESESPPS*PPPS*PDR 
                 1247 
                 Ehmt2 
                 Euchromatic histone lysine N- 
                 −3.071 
               
               
                   
                 {circumflex over ( )}R{circumflex over ( )} 
                   
                   
                 methyltransferase 2 
               
               
                   
               
               
                 IPI:IPI00221889.2 
                 ILS*DDEDEDEEDAFK 
                 1248 
                 Ercc6l 
                 DNA excision repair protein ERCC-6- 
                 −3.063 
               
               
                   
                   
                   
                   
                 like 
               
               
                   
               
               
                 IPI:IPI00130920.1 
                 TELS*PSFINPNPLEWFAGE 
                 1249 
                 Mtap1b 
                 Microtubule-associated protein 1B 
                 −3.052 
               
               
                   
                 EPTEESEKPLTQSGGAPPP 
               
               
                   
                 SGGK 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1250 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.033 
               
               
                   
                 GGTLFSTTPGGT*R 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTT* 
                 1251 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.031 
               
               
                   
                 PGGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTT* 
                 1252 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.031 
               
               
                   
                 PGGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTT* 
                 1253 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −3.031 
               
               
                   
                 PGGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00137465.1 
                 S*DGSLDDGDGIHR 
                 1254 
                 Serinc1 
                 Serine incorporator 1 
                 −3.027 
               
               
                   
               
               
                 IPI:IPI00130920.1 
                 QGFPDRES*PVSDLTSTGLY 
                 1255 
                 Mtap1b 
                 Microtubule-associated protein 1B 
                 −3 
               
               
                   
                 QDK 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1256 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.995 
               
               
                   
                 GGTLFSTTPGGT*R 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 RNSPMAQT*PPCHLPNIPGV 
                 1257 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 −2.988 
               
               
                   
                 TSPGALIEDSK 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00122757.1 
                 TDYYPEEMS*PPLMNPVSP 
                 1258 
                 Klf3; 
                 Krueppel-like factor 3 
                 −2.986 
               
               
                   
                 PQALLQENHPS*VIVQPGK@ 
                   
                 LOC100046855 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1259 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.972 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00126006.6 
                 TQT*PPLGQTPQLGLK 
                 1260 
                 Eif4g2 
                 Isoform 1 of Eukaryotic translation 
                 −2.956 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 2 
               
               
                   
               
               
                 IPI:IPI00460668.2 
                 KAENAEGQTPAIGPDGEPL 
                 1261 
                 Smarca4 
                 Putative uncharacterized protein 
                 −2.915 
               
               
                   
                 DETSQM#S*DLPVK 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGVT 
                 1262 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.908 
               
               
                   
                 SPTSDEPPMQASQSQLPS* 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 SPEDK 
               
               
                   
               
               
                 IPI:IPI00127764.2 
                 EGENVKPVNSGTWVAS*NS 
                 1263 
                 Pcm1 
                 Isoform 1 of Pericentriolar material 1 
                 −2.9 
               
               
                   
                 *ELTPSESLVTT*DDETFEK 
                   
                   
                 protein 
               
               
                   
               
               
                 IPI:IPI00874995.2 
                 AS*DDLGEPDVFATAPFR 
                 1264 
                 Aak1 
                 Uncharacterized protein FLJ45252 
                 −2.899 
               
               
                   
                   
                   
                   
                 homolog 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGVT 
                 1265 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.888 
               
               
                   
                 SPTSDEPPMQASQSQLPSS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 PEDK 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTTPG 
                 1266 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.884 
               
               
                   
                 GT*LFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00128564.1 
                 R{circumflex over ( )}AAAASAAEAGIAT*PGTE 
                 1267 
                 Psmd4 
                 Isoform Rpn10A of 26S proteasome 
                 −2.861 
               
               
                   
                 DSDDALLK@ 
                   
                   
                 non-ATPase regulatory subunit 4 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTTPG 
                 1268 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.846 
               
               
                   
                 GT*LFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1269 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.84 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00406741.5 
                 AAVGVTGNDITTPPNKEPPP 
                 1270 
                 Mtap4 
                 Isoform 4 of Microtubule-associated 
                 −2.832 
               
               
                   
                 S*PEKK 
                   
                   
                 protein 4 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1271 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.799 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1272 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.799 
               
               
                   
                 GGTLFST*TPGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1273 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.794 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTTPG 
                 1274 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.776 
               
               
                   
                 GT*LFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 NS*PMAQTPPCHLPNIPGVT 
                 1275 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 −2.763 
               
               
                   
                 SPGALIEDSK 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1276 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.762 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1277 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.756 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00331177.2 
                 VSS*TPETPLTK@ 
                 1278 
                 Pola2 
                 DNA polymerase alpha subunit B 
                 −2.747 
               
               
                   
               
               
                 IPI:IPI00109318.1 
                 NSPMAQT*PPCHLPNIPGVT 
                 1279 
                 Eif4ebp2 
                 Eukaryotic translation initiation 
                 −2.714 
               
               
                   
                 SPGALIEDSK 
                   
                   
                 factor 4E-binding protein 2 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTTPG 
                 1280 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.672 
               
               
                   
                 GT*LFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1281 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.672 
               
               
                   
                 GGTLFSTTPGGT*R 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1282 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.672 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00322707.5 
                 IK@PVTENLVLPSHTGFCQ 
                 1283 
                 Atrx 
                 Transcriptional regulator ATRX 
                 −2.663 
               
               
                   
                 S*S*GDEALSK@ 
               
               
                   
               
               
                 IPI:IPI00322707.5 
                 IK@PVTENLVLPSHTGFCQ 
                 1284 
                 Atrx 
                 Transcriptional regulator ATRX 
                 −2.663 
               
               
                   
                 S*S*GDEALSK@ 
               
               
                   
               
               
                 IPI:IPI00918973.1 
                 IGFPETAEEELEEIASENS*D 
                 1285 
                 Strap 
                 Serine-threonine kinase receptor- 
                 −2.612 
               
               
                   
                 SIYSSTPEVK 
                   
                   
                 associated protein 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYS*TTP 
                 1286 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.565 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00125960.1 
                 TAS*GSS*VTS*LEGTR 
                 1287 
                 Ndrg1 
                 Protein NDRG1 
                 −2.557 
               
               
                   
               
               
                 IPI:IPI00125960.1 
                 TAS*GSS*VTS*LEGTR 
                 1288 
                 Ndrg1 
                 Protein NDRG1 
                 −2.557 
               
               
                   
               
               
                 IPI:IPI00125960.1 
                 TAS*GSSVTS*LEGTR 
                 1289 
                 Ndrg1 
                 Protein NDRG1 
                 −2.546 
               
               
                   
               
               
                 IPI:IPI00323045.3 
                 S*MDVDLNQAHMEDTPK@ 
                 1290 
                 Melk 
                 Maternal embryonic leucine zipper 
                 −2.53 
               
               
                   
                   
                   
                   
                 kinase 
               
               
                   
               
               
                 IPI:IPI00465761.5 
                 SQLVHGCSQDSDELNPGGL 
                 1291 
                 Arhgef17 
                 Isoform 1 of Rho guanine nucleotide 
                 −2.526 
               
               
                   
                 GSAGGVGS*PEPPTS*PR{circumflex over ( )} 
                   
                   
                 exchange factor 17 
               
               
                   
               
               
                 IPI:IPI00465761.5 
                 SQLVHGCSQDSDELNPGGL 
                 1292 
                 Arhgef17 
                 Isoform 1 of Rho guanine nucleotide 
                 −2.513 
               
               
                   
                 GSAGGVGS*PEPPTS*PR{circumflex over ( )} 
                   
                   
                 exchange factor 17 
               
               
                   
               
               
                 IPI:IPI00274140.4 
                 LSPFFTLDLSPT*DDK@SSK 
                 1293 
                 Grit 
                 Isoform 2 of Rho/Cdc42/Rac GTPase- 
                 −2.507 
               
               
                   
                 @PSSFTEK@ 
                   
                   
                 activating protein RICS 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTT* 
                 1294 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.506 
               
               
                   
                 PGGTLFSTFPGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00314240.5 
                 K@QPPVS*PGTALVGSQK@ 
                 1295 
                 Hmga1 
                 Isoform HMG-I of High mobility group 
                 −2.493 
               
               
                   
                   
                   
                   
                 protein HMG-I/HMG-Y 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1296 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.484 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00135379.3 
                 VSPMLPSSSLES*PKDK 
                 1297 
                 Myo9b 
                 Isoform 1 of Myosin-IXb 
                 −2.452 
               
               
                   
               
               
                 IPI:IPI00753701.3 
                 SQSGS*PAAPVEQVVIHTDT 
                 1298 
                 Mdc1 
                 mediator of DNA damage checkpoint 1 
                 −2.44 
               
               
                   
                 SGDPTLPQR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00221889.2 
                 R{circumflex over ( )}ILS*DDEDEDEEDAFK@ 
                 1299 
                 Ercc6l 
                 DNA excision repair protein ERCC-6- 
                 −2.438 
               
               
                   
                   
                   
                   
                 like 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTT* 
                 1300 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.437 
               
               
                   
                 PGGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYS*TT 
                 1301 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.437 
               
               
                   
                 PGGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00454138.4 
                 K@QQHVISTEEGDM#M#ET 
                 1302 
                 Sap130 
                 Isoform 1 of Histone deacetylase 
                 −2.434 
               
               
                   
                 *NST*DDEK@ 
                   
                   
                 complex subunit SAP130 
               
               
                   
               
               
                 IPI:IPI00454138.4 
                 K@QQHVISTEEGDM#M#ET 
                 1303 
                 Sap130 
                 Isoform 1 of Histone deacetylase 
                 −2.434 
               
               
                   
                 *NS*TDDEK@ 
                   
                   
                 complex subunit SAP130 
               
               
                   
               
               
                 IPI:IPI00753701.3 
                 SQSGS*PAAPVEQVVIHTDT 
                 1304 
                 Mdc1 
                 mediator of DNA damage checkpoint 1 
                 −2.433 
               
               
                   
                 SGDPTLPQR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00654388.2 
                 AENQR{circumflex over ( )}PAEDSALS*PGPLA 
                 1305 
                 Lrrfip1 
                 Isoform 1 of Leucine-rich repeat 
                 −2.425 
               
               
                   
                 GAK@ 
                   
                   
                 flightless-interacting protein 1 
               
               
                   
               
               
                 IPI:IPI00654388.2 
                 AENQRPAEDSALS*PGPLA 
                 1306 
                 Lrrfip1 
                 Isoform 1 of Leucine-rich repeat 
                 −2.425 
               
               
                   
                 GAK 
                   
                   
                 flightless-interacting protein 1 
               
               
                   
               
               
                 IPI:IPI00330121.4 
                 GLPYADHNYGAPPPPT*PP 
                 1307 
                 Setd5 
                 Isoform 2 of SET domain-containing 
                 −2.414 
               
               
                   
                 AS*PPVQTIIPR{circumflex over ( )} 
                   
                   
                 protein 5 
               
               
                   
               
               
                 IPI:IPI00323256.3 
                 HGS*SSYPPVIYSPLMPK 
                 1308 
                 Zfpm2 
                 Isoform 1 of Zinc finger protein ZFPM2 
                 −2.405 
               
               
                   
               
               
                 IPI:IPI00323256.3 
                 HGSSS*YPPVIYSPLMPK 
                 1309 
                 Zfpm2 
                 Isoform 1 of Zinc finger protein ZFPM2 
                 −2.405 
               
               
                   
               
               
                 IPI:IPI00323256.3 
                 HGSS*SYPPVIYSPLMPK@ 
                 1310 
                 Zfpm2 
                 Isoform 1 of Zinc finger protein ZFPM2 
                 −2.395 
               
               
                   
               
               
                 IPI:IPI00123474.2 
                 AGADIHAENEEPLCPLPSPS 
                 1311 
                 Nfkb2 
                 NF-kB2 splice variant 4 
                 −2.389 
               
               
                   
                 TSGSDS*DSEGPER{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00117689.1 
                 EGDELGEGERPEDDTAAIE 
                 1312 
                 Ptrf 
                 Polymerase I and transcript release 
                 −2.385 
               
               
                   
                 LS*S*DEAVEVEEVIEESR 
                   
                   
                 factor 
               
               
                   
               
               
                 IPI:IPI00117689.1 
                 EGDELGEGERPEDDTAAIE 
                 1313 
                 Ptrf 
                 Polymerase I and transcript release 
                 −2.385 
               
               
                   
                 LS*S*DEAVEVEEVIEESR 
                   
                   
                 factor 
               
               
                   
               
               
                 IPI:IPI00127764.2 
                 RSS*LVDEAPEDEEFEQK 
                 1314 
                 Pcm1 
                 Isoform 1 of Pericentriolar material 1 
                 −2.38 
               
               
                   
                   
                   
                   
                 protein 
               
               
                   
               
               
                 IPI:IPI00330121.4 
                 GLPYADHNYGAPPPPT*PP 
                 1315 
                 Setd5 
                 Isoform 2 of SET domain-containing 
                 −2.359 
               
               
                   
                 AS*PPVQTIIPR 
                   
                   
                 protein 5 
               
               
                   
               
               
                 IPI:IPI00121277.1 
                 VAAAAGSGPS*PPCS*PGH 
                 1316 
                 Pi4k2a 
                 Phosphatidylinositol 4-kinase type 2- 
                 −2.354 
               
               
                   
                 DR 
                   
                   
                 alpha 
               
               
                   
               
               
                 IPI:IPI00331361.2 
                 SPT*KAEPATPAEAAQSDR 
                 1317 
                 Mybbp1a 
                 Myb-binding protein 1A 
                 −2.35 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTT* 
                 1318 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.341 
               
               
                   
                 PGGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00330121.4 
                 GLPYADHNYGAPPPPT*PP 
                 1319 
                 Setd5 
                 Isoform 2 of SET domain-containing 
                 −2.334 
               
               
                   
                 AS*PPVQTIIPIR{circumflex over ( )} 
                   
                   
                 protein 5 
               
               
                   
               
               
                 IPI:IPI00623284.4 
                 IWDPTPS*HTPAGAAT*PGR 
                 1320 
                 Sf3b1 
                 Splicing factor 3B subunit 1 
                 −2.329 
               
               
                   
                 GDT*PGHAT*PGHGGATSS 
               
               
                   
                 AR 
               
               
                   
               
               
                 IPI:IPI00153715.5 
                 TEDEEFLIQHLLQAPS*PPR 
                 1321 
                 Prr12 
                 proline rich 12 
                 −2.321 
               
               
                   
               
               
                 IPI:IPI00116268.3 
                 SGS*CSS*PQPKPNY*PPLS* 
                 1322 
                 N4bp1 
                 N4bp1 protein 
                 −2.307 
               
               
                   
                 PPLPLPQLLPSVT*EAR 
               
               
                   
               
               
                 IPI:IPI00322707.5 
                 AK@QPVIGDQNS*DSDEM# 
                 1323 
                 Atrx 
                 Transcriptional regulator ATRX 
                 −2.262 
               
               
                   
                 LAVLK@ 
               
               
                   
               
               
                 IPI:IPI00322707.5 
                 AKQPVIGDQNS*DSDEM#LA 
                 1324 
                 Atrx 
                 Transcriptional regulator ATRX 
                 −2.262 
               
               
                   
                 VLK 
               
               
                   
               
               
                 IPI:IPI00461244.3 
                 DTTS*FEDISPQGISDDSST 
                 1325 
                 Ccdc88a 
                 Isoform 2 of Girdin 
                 −2.242 
               
               
                   
                 GSR 
               
               
                   
               
               
                 IPI:IPI00317794.5 
                 KEDS*DEDEDEEDEDDS*D 
                 1326 
                 Ncl 
                 Nucleolin 
                 −2.198 
               
               
                   
                 EDEDDEEEDEFEPPIVK 
               
               
                   
               
               
                 IPI:IPI00317794.5 
                 K@EDS*DEDEDEEDEDDS* 
                 1327 
                 Ncl 
                 Nucleolin 
                 −2.198 
               
               
                   
                 DEDEDDEEEDEFEPPIVK@ 
               
               
                   
               
               
                 IPI:IPI00400381.9 
                 AHS*LLFENSDSFSEDTGTL 
                 1328 
                 Phactr4 
                 Isoform 1 of Phosphatase and actin 
                 −2.193 
               
               
                   
                 GR{circumflex over ( )} 
                   
                   
                 regulator 4 
               
               
                   
               
               
                 IPI:IPI00320208.3 
                 YGPSSVEDTTGSGAADAKD 
                 1329 
                 Eef1b2 
                 Elongation factor 1-beta 
                 −2.192 
               
               
                   
                 DDDIDLFGS*DDEEESEEAK 
               
               
                   
               
               
                 IPI:IPI00923656.1 
                 R{circumflex over ( )}DS*SSLSSPLNPK@ 
                 1330 
                 Baz1b 
                 Isoform 1 of Tyrosine-protein kinase 
                 −2.17 
               
               
                   
                   
                   
                   
                 BAZ1B 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTTPG 
                 1331 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.17 
               
               
                   
                 GT*LFST*TPGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00108389.5 
                 ETVVSGPLGVEDISPSMS*P 
                 1332 
                 Trp53bp1 
                 Transformation related protein 53 
                 −2.161 
               
               
                   
                 DDK@ 
                   
                   
                 binding protein 1 
               
               
                   
               
               
                 IPI:IPI00415558.1 
                 AASPAKPS*SLDLVPNLPR 
                 1333 
                 Synpo 
                 Isoform 3 of Synaptopodin 
                 −2.151 
               
               
                   
               
               
                 IPI:IPI00404545.2 
                 SCSVT*DTVAEQAHLPPPSV 
                 1334 
                 Nedd4I 
                 Isoform 3 of E3 ubiquitin-protein 
                 −2.113 
               
               
                   
                 AYVHTTPGLPSGWEER 
                   
                   
                 ligase NEDD4-like 
               
               
                   
               
               
                 IPI:IPI00416203.1 
                 AVPFVPM#SYQLS*QS*Y*Y 
                 1335 
                 Gtf3c1 
                 Isoform 2 of General transcription 
                 −2.105 
               
               
                   
                 S*LGK 
                   
                   
                 factor 3C polypeptide 1 
               
               
                   
               
               
                 IPI:IPI00355042.3 
                 IPMPPSS*PQPR 
                 1336 
                 Ppp1r13l 
                 RelA-associated inhibitor 
                 −2.104 
               
               
                   
               
               
                 IPI:IPI00320208.3 
                 YGPSSVEDTTGSGAADAKDK 
                 1337 
                 Eef1b2 
                 Elongation factor 1-beta 
                 −2.096 
               
               
                   
                 DDDIDLFGS*DDEEESEEAKK 
               
               
                   
               
               
                 IPI:IPI00623382.2 
                 LMKPPS*PEHQS*PDTQQE 
                 1338 
                 Morc2a 
                 MORC family CW-type zinc finger 
                 −2.069 
               
               
                   
                 GGEEEEAMVAR 
                   
                   
                 protein 2A 
               
               
                   
               
               
                 IPI:IPI00125960.1 
                 TAS*GSS*VTSLEGTR 
                 1339 
                 Ndrg1 
                 Protein NDRG1 
                 −2.055 
               
               
                   
               
               
                 IPI:IPI00125960.1 
                 TAS*GSS*VTSLEGTR 
                 1340 
                 Ndrg1 
                 Protein NDRG1 
                 −2.055 
               
               
                   
               
               
                 IPI:IPI00125960.1 
                 TAS*GSS*VTSLEGTR{circumflex over ( )} 
                 1341 
                 Ndrg1 
                 Protein NDRG1 
                 −2.055 
               
               
                   
               
               
                 IPI:IPI00330121.4 
                 GLPYADHNYGAPPPPT*PP 
                 1342 
                 Setd5 
                 Isoform 2 of SET domain-containing 
                 −2.045 
               
               
                   
                 AS*PPVQTIIPR{circumflex over ( )} 
                   
                   
                 protein 5 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTT* 
                 1343 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.035 
               
               
                   
                 PGGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00226701.3 
                 ILGDHLLLDPAHELPPY*TPP 
                 1344 
                 Trerf1 
                 Isoform 4 of Transcriptional-regulating 
                 −2.03 
               
               
                   
                 PMLS*PVR 
                   
                   
                 factor 1 
               
               
                   
               
               
                 IPI:IPI00348488.5 
                 SCS*M#ELHGEGNQEPGSP 
                 1345 
                 Dennd4c 
                 DENN/MADD domain containing 4C 
                 −2.012 
               
               
                   
                 AVFAHPLER{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTT* 
                 1346 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −2.01 
               
               
                   
                 PGGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00317794.5 
                 K@EDS*DEDEDEEDEDDS* 
                 1347 
                 Ncl 
                 Nucleolin 
                 −1.999 
               
               
                   
                 DEDEDDEEEDEFEPPIVK@ 
               
               
                   
               
               
                 IPI:IPI00124717.1 
                 K@PEFS*PTLK@ 
                 1348 
                 Orc6l 
                 Origin recognition complex subunit 6 
                 −1.969 
               
               
                   
               
               
                 IPI:IPI00380722.1 
                 SET*PPVPPPPPYLANYPGF 
                 1349 
                 Bat2 
                 Large proline-rich protein BAT2 
                 −1.961 
               
               
                   
                 PENGTPGPPISR 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 SNSFS*DEREFSAPSTPTGT 
                 1350 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 −1.95 
               
               
                   
                 LEFAGGDAK 
               
               
                   
               
               
                 IPI:IPI00108389.5 
                 LVS*PETEASEESLQFSLEK 
                 1351 
                 Trp53bp1 
                 Transformation related protein 53 
                 −1.94 
               
               
                   
                 @PTTAER{circumflex over ( )} 
                   
                   
                 binding protein 1 
               
               
                   
               
               
                 IPI:IPI00124272.1 
                 LTTTGQVTS*PVK@ 
                 1352 
                 Lig3 
                 Isoform Alpha of DNA ligase 3 
                 −1.932 
               
               
                   
               
               
                 IPI:IPI00406741.5 
                 AAVGVTGNDITTPPNKEPPP 
                 1353 
                 Mtap4 
                 Isoform 4 of Microtubule-associated 
                 −1.932 
               
               
                   
                 S*PEKK 
                   
                   
                 protein 4 
               
               
                   
               
               
                 IPI:IPI00321774.2 
                 HLLTDLPLPPELPGGDPSPP 
                 1354 
                 Crkrs 
                 Isoform 2 of Cell division cycle 2- 
                 −1.921 
               
               
                   
                 DS*PEPK@ 
                   
                   
                 related protein kinase 7 
               
               
                   
               
               
                 IPI:IPI00321774.2 
                 HLLTDLPLPPELPGGDPSPP 
                 1355 
                 Crkrs 
                 Isoform 2 of Cell division cycle 2- 
                 −1.921 
               
               
                   
                 DS*PEPK@ 
                   
                   
                 related protein kinase 7 
               
               
                   
               
               
                 IPI:IPI00124914.1 
                 S*LHKPMY*FFLINL 
                 1356 
                 Olfr521 
                 Olfactory receptor Olfr521 
                 −1.913 
               
               
                   
                 S*ALDILFTT*TTVPK 
               
               
                   
               
               
                 IPI:IPI00123881.1 
                 VETPDVNLDQEEEIQM#ET 
                 1357 
                 Mcm6 
                 DNA replication licensing factor MCM6 
                 −1.909 
               
               
                   
                 DEGQGGVNGHADS*PAPV 
               
               
                   
                 NR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00123881.1 
                 VETPDVNLDQEEEIQM#ET 
                 1358 
                 Mcm6 
                 DNA replication licensing factor MCM6 
                 −1.909 
               
               
                   
                 DEGQGGVNGHADS*PAPV 
               
               
                   
                 NR 
               
               
                   
               
               
                 IPI:IPI00117932.2 
                 S*PPVQPHTPVTISLGTAPS 
                 1359 
                 Sin3a 
                 Isoform 1 of Paired amphipathic helix 
                 −1.896 
               
               
                   
                 LQNNQPVEFNHAINYVNK 
                   
                   
                 protein Sin3a 
               
               
                   
               
               
                 IPI:IPI00229571.1 
                 ISS*K@S*PGHM#VILNQTK@ 
                 1360 
                 Sltm 
                 Isoform 1 of SAFB-like transcription 
                 −1.88 
               
               
                   
                   
                   
                   
                 modulator 
               
               
                   
               
               
                 IPI:IPI00124753.3 
                 SLLLADSNGYTNLPDVVQP 
                 1361 
                 Mink1 
                 misshapen-like kinase 1 isoform 2 
                 −1.868 
               
               
                   
                 SHSPTENS*K 
               
               
                   
               
               
                 IPI:IPI00117088.2 
                 LS*VVGPPNR{circumflex over ( )} 
                 1362 
                 Map3k2 
                 Mitogen-activated protein kinase kinase 
                 −1.86 
               
               
                   
                   
                   
                   
                 kinase 2 
               
               
                   
               
               
                 IPI:IPI00127602.1 
                 VVVADDDSEAPER{circumflex over ( )}PVNGA 
                 1363 
                 Slc30a4 
                 Zinc transporter 4 
                 −1.822 
               
               
                   
                 HPALQADDDS*LLDQDLPLT 
               
               
                   
                 NSQLSLK@ 
               
               
                   
               
               
                 IPI:IPI00127602.1 
                 VVVADDDSEAPER{circumflex over ( )}PVNGA 
                 1364 
                 Slc30a4 
                 Zinc transporter 4 
                 −1.822 
               
               
                   
                 HPALQADDDS*LLDQDLPLT 
               
               
                   
                 NSQLSLK@ 
               
               
                   
               
               
                 IPI:IPI00228942.4 
                 DLS*PGAPPAVAAAAPEER{circumflex over ( )} 
                 1365 
                 Hectd2 
                 Hectd2 protein 
                 −1.792 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 EMPGSNIES*S*PEVEERPA 
                 1366 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.785 
               
               
                   
                 VLSALDQSQSQPSK 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00127602.1 
                 VVVADDDSEAPERPVNGAH 
                 1367 
                 Slc30a4 
                 Zinc transporter 4 
                 −1.782 
               
               
                   
                 PALQADDDS*LLDQDLPLTN 
               
               
                   
                 SQLSLK 
               
               
                   
               
               
                 IPI:IPI00127602.1 
                 VVVADDDSEAPERPVNGAH 
                 1368 
                 Slc30a4 
                 Zinc transporter 4 
                 −1.782 
               
               
                   
                 PALQADDDS*LLDQDLPLTN 
               
               
                   
                 SQLSLK 
               
               
                   
               
               
                 IPI:IPI00551082.3 
                 EK@PPFLPEEPSS*S*SEED 
                 1369 
                 Rbbp6 
                 Isoform 2 of Retinoblastoma-binding 
                 −1.768 
               
               
                   
                 DPIPDELLCLICK@ 
                   
                   
                 protein 6 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTT* 
                 1370 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −1.759 
               
               
                   
                 PGGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 RVALGDGVQLPPGDYSTT* 
                 1371 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −1.759 
               
               
                   
                 PGGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00135660.5 
                 FQHPNTDMLQEK@PSSPS 
                 1372 
                 Sdpr 
                 Serum deprivation-response protein 
                 −1.749 
               
               
                   
                 PMPSST*PSPSLNLGSTEEA 
               
               
                   
                 IR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00131725.3 
                 HQIVCINNDLS*EEES*DDES 
                 1373 
                 Npm3 
                 Nucleoplasmin-3 
                 −1.749 
               
               
                   
                 *EEDEIKLCGILPAK 
               
               
                   
               
               
                 IPI:IPI00320208.3 
                 YGPSSVEDTTGSGAADAKD 
                 1374 
                 Eef1b2 
                 Elongation factor 1-beta 
                 −1.741 
               
               
                   
                 DDDIDLFGS*DDEEESEEAKK 
               
               
                   
               
               
                 IPI:IPI00321774.2 
                 HLLTDLPLPPELPGGDPS*P 
                 1375 
                 Crkrs 
                 Isoform 2 of Cell division cycle 2- 
                 −1.734 
               
               
                   
                 PDSPEPK@ 
                   
                   
                 related protein kinase 7 
               
               
                   
               
               
                 IPI:IPI00420601.5 
                 T*CDSPQNPVDFISGPVPDS 
                 1376 
                 Usp10 
                 Ubiquitin carboxyl-terminal hydrolase 
                 −1.734 
               
               
                   
                 PFPR{circumflex over ( )} 
                   
                   
                 10 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 1377 
                 Npm1 
                 Nucleophosmin 
                 −1.718 
               
               
                   
                 AES*EDEDEEDVK@ 
               
               
                   
               
               
                 IPI:IPI00464324.2 
                 AS*CEENLPVFIASELAK@ 
                 1378 
                 D830031N03Rik 
                 similar to mKIAA0754 protein 
                 −1.718 
               
               
                   
               
               
                 IPI:IPI00318048.5 
                 SSPKEEVAS*EPEEAAS*PT 
                 1379 
                 Nop56 
                 Nucleolar protein 56 
                 −1.708 
               
               
                   
                 T*PK 
               
               
                   
               
               
                 IPI:IPI00115257.1 
                 QVDTEEAGMVTAAT*ASNV 
                 1380 
                 Psip1 
                 Isoform 1 of PC4 and SFRS1- 
                 −1.694 
               
               
                   
                 KASPK 
                   
                   
                 interacting protein 
               
               
                   
               
               
                 IPI:IPI00317794.5 
                 KEDS*DEDEDEEDEDDS*D 
                 1381 
                 Ncl 
                 Nucleolin 
                 −1.692 
               
               
                   
                 EDEDDEEEDEFEPPIVK 
               
               
                   
               
               
                 IPI:IPI00125745.1 
                 HAELSGS*PLK@ 
                 1382 
                 Mta3 
                 Isoform 1 of Metastasis associated 
                 −1.69 
               
               
                   
                   
                   
                   
                 protein MTA3 
               
               
                   
               
               
                 IPI:IPI00461272.6 
                 RGS*PGGVEMNVELPQQE 
                 1383 
                 2310047M10Rik 
                 Putative uncharacterized protein 
                 −1.686 
               
               
                   
                 GDDDDDEDEEAAAGR 
               
               
                   
               
               
                 IPI:IPI00453999.2 
                 K@PS*VPDTASPADDSFVD 
                 1384 
                 Nck1 
                 non-catalytic region of tyrosine kinase 
                 −1.682 
               
               
                   
                 PGER{circumflex over ( )} 
                   
                   
                 adaptor protein 1 
               
               
                   
               
               
                 IPI:IPI00119442.1 
                 M#DTGEVSDIGSQGAPIVLS 
                 1385 
                 Exosc9 
                 Exosome complex exonuclease RRP45 
                 −1.674 
               
               
                   
                 *DS*EEEEMIILEPEK@NPK@ 
               
               
                   
               
               
                 IPI:IPI00654388.2 
                 AENQRPAEDSALS*PGPLA 
                 1386 
                 Lrrfip1 
                 Isoform 1 of Leucine-rich repeat 
                 −1.673 
               
               
                   
                 GAK 
                   
                   
                 flightless-interacting protein 1 
               
               
                   
               
               
                 IPI:IPI00128975.3 
                 DK@DDQEWEST*SPPK@P 
                 1387 
                 Dap 
                 Death-associated protein 1 
                 −1.669 
               
               
                   
                 TVFISGVIAR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00153375.1 
                 SACFSPVSLS*PR{circumflex over ( )}PCSPFS 
                 1388 
                 Pdlim2 
                 PDZ and LIM domain protein 2 
                 −1.659 
               
               
                   
                 T*PPPTS*PVALSK@ 
               
               
                   
               
               
                 IPI:IPI00515576.5 
                 LDGELAITKPNVSS*PSK 
                 1389 
                 Ehbp1 
                 Isoform 2 of EH domain-binding 
                 −1.659 
               
               
                   
                   
                   
                   
                 protein 1 
               
               
                   
               
               
                 IPI:IPI00169521.4 
                 ALAEEDS*EDELPS*DVDFN 
                 1390 
                 Esf1 
                 ESF1 homolog 
                 −1.656 
               
               
                   
                 DPYFAEEVKK 
               
               
                   
               
               
                 IPI:IPI00405756.8 
                 SISGTS*TSEK@PNSMDTA 
                 1391 
                 Rasal2 
                 RAS protein activator like 2 
                 −1.654 
               
               
                   
                 NTSPFK@ 
               
               
                   
               
               
                 IPI:IPI00108508.5 
                 ET*PPTPT*S*SPAEFSPK 
                 1392 
                 4921517D21Rik 
                 RIKEN cDNA 4921517D21 gene 
                 −1.652 
               
               
                   
               
               
                 IPI:IPI00652649.1 
                 IRPPPELETS*LTERPSS*PS 
                 1393 
                 Als2cr4 
                 Amyotrophic lateral sclerosis 2 
                 −1.649 
               
               
                   
                 LLR 
                   
                   
                 chromosomal region candidate gene 4 
               
               
                   
                   
                   
                   
                 protein homolog 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 LKCGSGPVHISGQHLVAVE 
                 1394 
                 Npm1 
                 Nucleophosmin 
                 −1.638 
               
               
                   
                 EDAES*EDEDEEDVK 
               
               
                   
               
               
                 IPI:IPI00453603.1 
                 TPVS*PVKFS*PGDFWGR 
                 1395 
                 Rps6kb1 
                 Isoform Alpha I of Ribosomal protein 
                 −1.635 
               
               
                   
                   
                   
                   
                 S6 kinase beta-1 
               
               
                   
               
               
                 IPI:IPI00313307.3 
                 LSSS*DSIGPDVTDILSDIAE 
                 1396 
                 Med1 
                 Isoform 4 of Mediator of RNA 
                 −1.624 
               
               
                   
                 EASK@LPSTSDDCPPIGT*P 
                   
                   
                 polymerase II transcription subunit 1 
               
               
                   
                 VR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00379682.1 
                 ANTLSHFPVECPAPPEPAQ 
                 1397 
                 Tbc1d1 
                 Isoform 1 of TBC1 domain family 
                 −1.623 
               
               
                   
                 SS*PGVSQR{circumflex over ( )} 
                   
                   
                 member 1 
               
               
                   
               
               
                 IPI:IPI00379682.1 
                 ANTLSHFPVECPAPPEPAQ 
                 1398 
                 Tbc1d1 
                 Isoform 1 of TBC1 domain family 
                 −1.623 
               
               
                   
                 S*SPGVSQR{circumflex over ( )} 
                   
                   
                 member 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1399 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −1.621 
               
               
                   
                 GGTLFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 IPI:IPI00351206.5 
                 LLK@PGEEPSEY*T*DEEDT 
                 1400 
                 Pgrmc2 
                 Membrane-associated progesterone 
                 −1.62 
               
               
                   
                 K@ 
                   
                   
                 receptor component 2 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 NSGPVSEVNTGFS*PEVK@ 
                 1401 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.616 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00112339.9 
                 R{circumflex over ( )}LS*ENNCSLDDWEIGAGH 
                 1402 
                 Lima1 
                 LIM domain and actin binding 1 
                 −1.615 
               
               
                   
                 LSSSAFNSEK@ 
                   
                   
                 isoform a 
               
               
                   
               
               
                 IPI:IPI00112339.9 
                 R{circumflex over ( )}LS*ENNCSLDDWEIGAGH 
                 1403 
                 Lima1 
                 LIM domain and actin binding 1 
                 −1.615 
               
               
                   
                 LSSSAFNSEK@ 
                   
                   
                 isoform a 
               
               
                   
               
               
                 IPI:IPI00515576.5 
                 LDGELAITKPNVSS*PSK 
                 1404 
                 Ehbp1 
                 Isoform 2 of EH domain-binding 
                 −1.612 
               
               
                   
                   
                   
                   
                 protein 1 
               
               
                   
               
               
                 IPI:IPI00229472.5 
                 VEEQVEDS*DDEEDDDS*H 
                 1405 
                 Rbm28 
                 RNA-binding protein 28 
                 −1.609 
               
               
                   
                 DDEEER 
               
               
                   
               
               
                 IPI:IPI00229472.5 
                 VEEQVEDS*DDEEDDDS*H 
                 1406 
                 Rbm28 
                 RNA-binding protein 28 
                 −1.609 
               
               
                   
                 DDEEER{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGVT 
                 1407 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −1.6 
               
               
                   
                 SPTSDEPPM#QASQSQLPS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 SPEDK 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 LKCGSGPVHISGQHLVAVE 
                 1408 
                 Npm1 
                 Nucleophosmin 
                 −1.599 
               
               
                   
                 EDAES*EDEDEEDVK 
               
               
                   
               
               
                 IPI:IPI00453837.2 
                 KLPPPPPQAPPEEENES*EP 
                 1409 
                 Kdm1 
                 Lysine-specific histone demethylase 1 
                 −1.587 
               
               
                   
                 EEPSGVEGAAFQSR 
               
               
                   
               
               
                 IPI:IPI00319933.4 
                 DGTAPPPQSPSSPGSGQD 
                 1410 
                 Pacsin3 
                 Protein kinase C and casein kinase II 
                 −1.565 
               
               
                   
                 EDWS*DEESPR 
                   
                   
                 substrate protein 3 
               
               
                   
               
               
                 IPI:IPI00125662.2 
                 S*PQVPAAQQMLNFPEK 
                 1411 
                 Smarcc1 
                 Isoform 1 of SWI/SNF complex subunit 
                 −1.554 
               
               
                   
                   
                   
                   
                 SMARCC1 
               
               
                   
               
               
                 IPI:IPI00230435.1 
                 SLTM#VEDNEDDDEDGEEL 
                 1412 
                 Lmna 
                 Isoform C2 of Lamin-A/C 
                 −1.546 
               
               
                   
                 LHHHR{circumflex over ( )}VS*GSR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00228748.1 
                 LDR{circumflex over ( )}AS*PDLWPEQLPGVAE 
                 1413 
                 Lin52; 
                 Protein lin-52 homolog 
                 −1.545 
               
               
                   
                 FAASFK@ 
                   
                 Gm7020 
               
               
                   
               
               
                 IPI:IPI00622364.4 
                 LPPPFPGMDPESEGAAGAS 
                 1414 
                 Snx1 
                 Sorting nexin-1 
                 −1.535 
               
               
                   
                 EPEAGDSDTEGEDIFTGAA 
               
               
                   
                 AAT*K@PQS*PK@ 
               
               
                   
               
               
                 IPI:IPI00117689.1 
                 GEATDLLRGS*S*PDVHTLL 
                 1415 
                 Ptrf 
                 Polymerase I and transcript release 
                 −1.532 
               
               
                   
                 EITEESDAVLVDK 
                   
                   
                 factor 
               
               
                   
               
               
                 IPI:IPI00117689.1 
                 GEATDLLR{circumflex over ( )}GS*S*PDVHTLL 
                 1416 
                 Ptrf 
                 Polymerase I and transcript release 
                 −1.532 
               
               
                   
                 EITEESDAVLVDK@ 
                   
                   
                 factor 
               
               
                   
               
               
                 IPI:IPI00606555.2 
                 KPEPEAGQAEPLS*PRPPP 
                 1417 
                 Rreb1 
                 Isoform 3 of Ras-responsive element- 
                 −1.526 
               
               
                   
                 CPTLSVTVEPK 
                   
                   
                 binding protein 1 
               
               
                   
               
               
                 IPI:IPI00606555.2 
                 KPEPEAGQAEPLS*PRPPP 
                 1418 
                 Rreb1 
                 Isoform 3 of Ras-responsive element- 
                 −1.526 
               
               
                   
                 CPTLSVTVEPK 
                   
                   
                 binding protein 1 
               
               
                   
               
               
                 IPI:IPI00380394.5 
                 IEEPVSM#EMDNHLSDKDE 
                 1419 
                 Ints3 
                 Integrator complex subunit 3 
                 −1.525 
               
               
                   
                 SCYDNAEAAFS*DDEEDLN 
               
               
                   
                 SK 
               
               
                   
               
               
                 IPI:IPI00229571.1 
                 IS*SK@S*PGHM#VILNQTK@ 
                 1420 
                 Sltm 
                 Isoform 1 of SAFB-like transcription 
                 −1.524 
               
               
                   
                   
                   
                   
                 modulator 
               
               
                   
               
               
                 IPI:IPI00551082.3 
                 EKPPFLPEEPS*S*SSEEDD 
                 1421 
                 Rbbp6 
                 Isoform 2 of Retinoblastoma-binding 
                 −1.522 
               
               
                   
                 PIPDELLCLICK 
                   
                   
                 protein 6 
               
               
                   
               
               
                 IPI:IPI00468896.7 
                 KGELMENDQDAMEYS*S*E 
                 1422 
                 Ddx46 
                 Isoform 1 of Probable ATP-dependent 
                 −1.517 
               
               
                   
                 EEEVDLQTALTGYQTK 
                   
                   
                 RNA helicase DDX46 
               
               
                   
               
               
                 IPI:IPI00280250.5 
                 VGES*SEDVALEEETIYENE 
                 1423 
                 Sh3pxd2a 
                 Isoform 1 of SH3 and PX domain- 
                 −1.513 
               
               
                   
                 GFR{circumflex over ( )}PYTEDTLSAR{circumflex over ( )} 
                   
                   
                 containing protein 2A 
               
               
                   
               
               
                 IPI:IPI00280250.5 
                 VGES*SEDVALEEETIYENE 
                 1424 
                 Sh3pxd2a 
                 Isoform 1 of SH3 and PX domain- 
                 −1.513 
               
               
                   
                 GFRPYTEDTLSAR 
                   
                   
                 containing protein 2A 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR 
                 1425 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.512 
               
               
                   
               
               
                 IPI:IPI00117929.1 
                 STEESLSEDAFTESELS*PIR 
                 1426 
                 Oxr1 
                 Isoform 2 of Oxidation resistance 
                 −1.51 
               
               
                   
                 {circumflex over ( )}EELLSSEPR{circumflex over ( )} 
                   
                   
                 protein 1 
               
               
                   
               
               
                 IPI:IPI00117929.1 
                 STEESLSEDAFTESELS*PIR 
                 1427 
                 Oxr1 
                 Isoform 2 of Oxidation resistance 
                 −1.51 
               
               
                   
                 {circumflex over ( )}EELLSSEPR{circumflex over ( )} 
                   
                   
                 protein 1 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR{circumflex over ( )} 
                 1428 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.509 
               
               
                   
               
               
                 IPI:IPI00130920.1 
                 AS*LS*PMDEPVPDSESPVE 
                 1429 
                 Mtap1b 
                 Microtubule-associated protein 1B 
                 −1.509 
               
               
                   
                 K@ 
               
               
                   
               
               
                 IPI:IPI00113362.2 
                 NSNSYGIPEPAHAY*AQPQT 
                 1430 
                 Crkl 
                 Crk-like protein 
                 −1.508 
               
               
                   
                 TTPLPTVASTPGAAINPLPS 
               
               
                   
                 TQNGPVFAK 
               
               
                   
               
               
                 IPI:IPI00331334.3 
                 VSSAPIPCPS*PSPAPSAVP 
                 1431 
                 Bag3 
                 BAG family molecular chaperone 
                 −1.508 
               
               
                   
                 S*PPK 
                   
                   
                 regulator 3 
               
               
                   
               
               
                 IPI:IPI00331209.1 
                 NSS*FVLPK 
                 1432 
                 Rin2 
                 Isoform 1 of Ras and Rab interactor 2 
                 −1.504 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 GHTQTWPDTSSPEVMQT*Q 
                 1433 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.504 
               
               
                   
                 VES*PLLQSK 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR{circumflex over ( )} 
                 1434 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.502 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR 
                 1435 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.502 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR 
                 1436 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.502 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR 
                 1437 
                 Flnc 
                 lsoform 1 of Filamin-C 
                 −1.497 
               
               
                   
               
               
                 IPI:IPI00126006.6 
                 TQT*PPLGQTPQLGLK@ 
                 1438 
                 Eif4g2 
                 Isoform 1 of Eukaryotic translation 
                 −1.492 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 2 
               
               
                   
               
               
                 IPI:IPI00113798.2 
                 ATWGDGGDNS*PSNVVSK 
                 1439 
                 Snap23 
                 Synaptosomal-associated protein 
                 −1.49 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR{circumflex over ( )} 
                 1440 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.483 
               
               
                   
               
               
                 IPI:IPI00169771.1 
                 EDGIDAVEVAADR{circumflex over ( )}PGS*PR{circumflex over ( )} 
                 1441 
                 BC031781 
                 UPF0667 protein C1orf55 homolog 
                 −1.482 
               
               
                   
               
               
                 IPI:IPI00169806.3 
                 GMEGLIS*PTEAVGNSCGA 
                 1442 
                 Nek9 
                 Serine/threonine-protein kinase Nek9 
                 −1.478 
               
               
                   
                 SSSCPGWLR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00117932.2 
                 S*PPVQPHTPVTISLGTAPS 
                 1443 
                 Sin3a 
                 Isoform 1 of Paired amphipathic helix 
                 −1.477 
               
               
                   
                 LQNNQPVEFNHAINYVNK@ 
                   
                   
                 protein Sin3a 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 NSGPVSEVNTGFS*PEVK@ 
                 1444 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.475 
               
               
                   
                   
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00128062.1 
                 RGQEELEVPVDPLPS*SPA 
                 1445 
                 Snx15 
                 Sorting nexin-15 
                 −1.472 
               
               
                   
                 QEALDLLFSCDSTEEASSSL 
               
               
                   
                 AR 
               
               
                   
               
               
                 IPI:IPI00224570.3 
                 GVNFAEEPMRS*DS*ENGE 
                 1446 
                 Prkar2b 
                 cAMP-dependent protein kinase type II- 
                 −1.468 
               
               
                   
                 EEEAAEAGAFNAPVINR 
                   
                   
                 beta regulatory subunit 
               
               
                   
               
               
                 IPI:IPI00380722.1 
                 SET*PPVPPPPPYLANYPGF 
                 1447 
                 Bat2 
                 Large proline-rich protein BAT2 
                 −1.463 
               
               
                   
                 PENGTPGPPISR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00330695.5 
                 GLLAQDLQAESSPPAS*PLL 
                 1448 
                 Fam129b 
                 Niban-like protein 1 
                 −1.46 
               
               
                   
                 NGAPVQESSQPVAVPEAS* 
               
               
                   
                 PPASPLR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00750546.1 
                 GGGQSS*PQEEPTWK@ 
                 1449 
                 Cwc22 
                 Novel protein 
                 −1.452 
               
               
                   
               
               
                 IPI:IPI00129356.1 
                 SGS*GMSVISSSSVDQR 
                 1450 
                 Itsn1 
                 Isoform 1 of Intersectin-1 
                 −1.451 
               
               
                   
               
               
                 IPI:IPI00753701.3 
                 SPT*LGEDS*DTEVDEDHKP 
                 1451 
                 Mdc1 
                 mediator of DNA damage checkpoint 1 
                 −1.447 
               
               
                   
                 GFADS*ETDVEEER 
               
               
                   
               
               
                 IPI:IPI00137730.7 
                 VLTPTQVMNR{circumflex over ( )}PSS*ISWDG 
                 1452 
                 Pebp1 
                 Phosphatidylethanolamine-binding 
                 −1.431 
               
               
                   
                 LDPGK@ 
                   
                   
                 protein 1 
               
               
                   
               
               
                 IPI:IPI00123802.5 
                 NIQQDNSEAGTQPQVQTDG 
                 1453 
                 Hsph1 
                 Isoform HSP105-alpha of Heat shock 
                 −1.428 
               
               
                   
                 QQTSQSPPS*PELTSEESK 
                   
                   
                 protein 105 kDa 
               
               
                   
                 @TPDADK@ 
               
               
                   
               
               
                 IPI:IPI00421179.1 
                 EATLPPVS*PPK@ 
                 1454 
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation 
                 −1.421 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 1 
               
               
                   
               
               
                 IPI:IPI00421179.1 
                 EATLPPVS*PPK 
                 1455 
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation 
                 −1.421 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 1 
               
               
                   
               
               
                 IPI:IPI00318006.5 
                 R{circumflex over ( )}IS*WPENSFDFVSK@ 
                 1456 
                 Serhl 
                 Serine hydrolase-like protein 
                 −1.411 
               
               
                   
               
               
                 IPI:IPI00318006.5 
                 R{circumflex over ( )}IS*WPENSFDFVSK@ 
                 1457 
                 Serhl 
                 Serine hydrolase-like protein 
                 −1.411 
               
               
                   
               
               
                 IPI:IPI00125501.1 
                 KAEEAT*PVTALR 
                 1458 
                 Epb4.1l3 
                 Isoform 1 of Band 4.1-like protein 3 
                 −1.408 
               
               
                   
               
               
                 IPI:IPI00405665.6 
                 K@IIETM#SS*PK@ 
                 1459 
                 Kif20b 
                 Isoform 1 of M-phase phosphoprotein 1 
                 −1.399 
               
               
                   
               
               
                 IPI:IPI00405665.6 
                 KIIETM#SS*PK 
                 1460 
                 Kif20b 
                 Isoform 1 of M-phase phosphoprotein 1 
                 −1.399 
               
               
                   
               
               
                 IPI:IPI00119442.1 
                 M#DTGEVSDIGSQGAPIVLS 
                 1461 
                 Exosc9 
                 Exosome complex exonuclease RRP45 
                 −1.396 
               
               
                   
                 *DS*EEEEMIILEPEK@NPK@ 
               
               
                   
               
               
                 IPI:IPI00121760.5 
                 LKTEEGEIVYS*AEESENR 
                 1462 
                 Hnrpll 
                 Isoform 1 of Heterogeneous nuclear 
                 −1.387 
               
               
                   
                   
                   
                   
                 ribonucleoprotein L-like 
               
               
                   
               
               
                 IPI:IPI00320208.3 
                 YGPSSVEDTTGSGAADAKD 
                 1463 
                 Eef1b2 
                 Elongation factor 1-beta 
                 −1.381 
               
               
                   
                 DDDIDLFGS*DDEEESEEAK 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR{circumflex over ( )} 
                 1464 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.373 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR 
                 1465 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.373 
               
               
                   
               
               
                 IPI:IPI00125348.2 
                 AEEQLPPLLSPPS*PSTPHSR 
                 1466 
                 Mprip 
                 Isoform 1 of Myosin phosphatase Rho- 
                 −1.371 
               
               
                   
                   
                   
                   
                 interacting protein 
               
               
                   
               
               
                 IPI:IPI00120095.2 
                 DFTKPQDGDIIAPLIT*PLK 
                 1467 
                 Samhd1 
                 SAM domain and HD domain- 
                 −1.371 
               
               
                   
                   
                   
                   
                 containing protein 1 
               
               
                   
               
               
                 IPI:IPI00756765.3 
                 ALVIQESESPPS*PPPS* 
                 1468 
                 Ehmt2 
                 Euchromatic histone lysine N- 
                 −1.368 
               
               
                   
                 PDRR 
                   
                   
                 methyltransferase 2 
               
               
                   
               
               
                 IPI:IPI00135708.1 
                 RKPVLPALTINPTIAEGPS*P 
                 1469 
                 Map2k2 
                 Dual specificity mitogen-activated 
                 −1.365 
               
               
                   
                 TSEGASEANLVDLQK 
                   
                   
                 protein kinase kinase 2 
               
               
                   
               
               
                 IPI:IPI00317794.5 
                 KEDS*DEDEDEEDEDDS*D 
                 1470 
                 Ncl 
                 Nucleolin 
                 −1.364 
               
               
                   
                 EDEDDEEEDEFEPPIVK 
               
               
                   
               
               
                 IPI:IPI00330695.5 
                 GLLAQDLQAESSPPASPLL 
                 1471 
                 Fam129b 
                 Niban-like protein 1 
                 −1.36 
               
               
                   
                 NGAPVQES*S*QPVAVPEAS 
               
               
                   
                 *PPASPLR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00330695.5 
                 GLLAQDLQAES*S*PPASPL 
                 1472 
                 Fam129b 
                 Niban-like protein 1 
                 −1.36 
               
               
                   
                 LNGAPVQESSQPVAVPEAS 
               
               
                   
                 *PPASPLR 
               
               
                   
               
               
                 IPI:IPI00453800.4 
                 K@PSSS*PDLWK@VS*PDQ 
                 1473 
                 Zfp828 
                 Zinc finger protein 828 
                 −1.358 
               
               
                   
                 R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00135443.2 
                 AS*PITNDGEDEFVPSDGLD 
                 1474 
                 Top2b 
                 DNA topoisomerase 2-beta 
                 −1.357 
               
               
                   
                 KDEYAFSSGK 
               
               
                   
               
               
                 IPI:IPI00227267.2 
                 EVENEQTPVS*EPEEEKGS 
                 1475 
                 Epb4.1l2 
                 Putative uncharacterized protein 
                 −1.357 
               
               
                   
                 QPGPPVER 
               
               
                   
               
               
                 IPI:IPI00649691.3 
                 LASEDAALVDDDEES*DTPA 
                 1476 
                 Cc2d1b 
                 Coiled-coil and C2 domain-containing 
                 −1.353 
               
               
                   
                 QAPLAK@ 
                   
                   
                 protein 1B 
               
               
                   
               
               
                 IPI:IPI00340860.5 
                 TAS*EGSEAETPEAPK@ 
                 1477 
                 Larp7 
                 Isoform 1 of La-related protein 7 
                 −1.347 
               
               
                   
               
               
                 IPI:IPI00320208.3 
                 YGPSSVEDTTGSGAADAKD 
                 1478 
                 Eef1b2 
                 Elongation factor 1-beta 
                 −1.336 
               
               
                   
                 DDDIDLFGS*DDEEESEEAK 
               
               
                   
               
               
                 IPI:IPI00320208.3 
                 YGPSSVEDTTGSGAADAKD 
                 1479 
                 Eef1b2 
                 Elongation factor 1-beta 
                 −1.336 
               
               
                   
                 DDDIDLFGS*DDEEESEEAK 
               
               
                   
               
               
                 IPI:IPI00750546.1 
                 GGGQSS*PQEEPTWK 
                 1480 
                 Cwc22 
                 Novel protein 
                 −1.327 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 1481 
                 Npm1 
                 Nucleophosmin 
                 −1.324 
               
               
                   
                 AES*EDEDEEDVK 
               
               
                   
               
               
                 IPI:IPI00123871.2 
                 VHEPPR{circumflex over ( )}EDTVPPK@PVPP 
                 1482 
                 Ncor2 
                 nuclear receptor co-repressor 2 
                 −1.31 
               
               
                   
                 VPPPTQHLQPEGDVSQQS 
               
               
                   
                 GGS*PR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00458583.3 
                 AKS*PQPPVEEEDEHFDDT 
                 1483 
                 Hnrnpu 
                 Putative uncharacterized protein 
                 −1.308 
               
               
                   
                 VVCLDTYNCDLHFK 
               
               
                   
               
               
                 IPI:IPI00124959.1 
                 GPIQTLGHTDESASDKGPT 
                 1484 
                 Mki67 
                 Ki-67 protein 
                 −1.306 
               
               
                   
                 QMPCNSLQPEQVDSFQSS* 
               
               
                   
                 PR 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR 
                 1485 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.29 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR{circumflex over ( )} 
                 1486 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.289 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR{circumflex over ( )} 
                 1487 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.289 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR 
                 1488 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.289 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR 
                 1489 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.289 
               
               
                   
               
               
                 IPI:IPI00270767.3 
                 M#K@ESETFSDSS*PIEIIDE 
                 1490 
                 Rtn4 
                 Isoform 2 of Reticulon-4 
                 −1.286 
               
               
                   
                 FPTFVSAK@ 
               
               
                   
               
               
                 IPI:IPI00318048.5 
                 SSPKEEVAS*EPEEAASPT* 
                 1491 
                 Nop56 
                 Nucleolar protein 56 
                 −1.284 
               
               
                   
                 TPK 
               
               
                   
               
               
                 IPI:IPI00276222.1 
                 LSIMTSENHLNNSDKEVDEV 
                 1492 
                 Fermt2 
                 Fermitin family homolog 2 
                 −1.279 
               
               
                   
                 DAALS*DLEITLEGGK 
               
               
                   
               
               
                 IPI:IPI00475055.3 
                 RCPS*T*DPEEAVEDAEGPS 
                 1493 
                 Zfhx3 
                 AT motif binding factor 1 
                 −1.274 
               
               
                   
                 EASADPEELAK 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR{circumflex over ( )} 
                 1494 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.273 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR 
                 1495 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.273 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR{circumflex over ( )} 
                 1496 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.273 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR 
                 1497 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.273 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR{circumflex over ( )} 
                 1498 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.273 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR 
                 1499 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.273 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGSITR{circumflex over ( )} 
                 1500 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.272 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 1501 
                 Npm1 
                 Nucleophosmin 
                 −1.271 
               
               
                   
                 AES*EDEDEEDVK@ 
               
               
                   
               
               
                 IPI:IPI00121277.1 
                 VAAAAGSGPS*PPCS*PGH 
                 1502 
                 Pi4k2a 
                 Phosphatidylinositol 4-kinase type 2- 
                 −1.266 
               
               
                   
                 DR 
                   
                   
                 alpha 
               
               
                   
               
               
                 IPI:IPI00121277.1 
                 VAAAAGSGPS*PPCS*PGH 
                 1503 
                 Pi4k2a 
                 Phosphatidylinositol 4-kinase type 2- 
                 −1.266 
               
               
                   
                 DR{circumflex over ( )} 
                   
                   
                 alpha 
               
               
                   
               
               
                 IPI:IPI00317794.5 
                 K@EDS*DEDEDEEDEDDS* 
                 1504 
                 Ncl 
                 Nucleolin 
                 −1.255 
               
               
                   
                 DEDEDDEEEDEFEPPIVK@ 
               
               
                   
               
               
                 IPI:IPI00270767.3 
                 VVKEDGVM#S*PEK 
                 1505 
                 Rtn4 
                 Isoform 2 of Reticulon-4 
                 −1.252 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGVT 
                 1506 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −1.238 
               
               
                   
                 SPTSDEPPM#QASQSQLPS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 SPEDK 
               
               
                   
               
               
                 IPI:IPI00114352.1 
                 VNHEPEPASGAS*PGATIPK 
                 1507 
                 Bin1 
                 Isoform 1 of Myc box-dependent- 
                 −1.237 
               
               
                   
                 @S*PSQLR{circumflex over ( )} 
                   
                   
                 interacting protein 1 
               
               
                   
               
               
                 IPI:IPI00114352.1 
                 VNHEPEPASGAS*PGATIPK 
                 1508 
                 Bin1 
                 Isoform 1 of Myc box-dependent- 
                 −1.237 
               
               
                   
                 S*PSQLR 
                   
                   
                 interacting protein 1 
               
               
                   
               
               
                 IPI:IPI00110435.2 
                 TPS*PEPVDK@DFYSEFGD 
                 1509 
                 Nisch 
                 Isoform 1 of Nischarin 
                 −1.229 
               
               
                   
                 K@ 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 1510 
                 Npm1 
                 Nucleophosmin 
                 −1.226 
               
               
                   
                 AES*EDEDEEDVK@ 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 1511 
                 Npm1 
                 Nucleophosmin 
                 −1.226 
               
               
                   
                 AES*EDEDEEDVK@ 
               
               
                   
               
               
                 IPI:IPI00132386.1 
                 ANS*TSDSMFTETPSPVLK@ 
                 1512 
                 Cdc42ep3 
                 Cdc42 effector protein 3 
                 −1.225 
               
               
                   
               
               
                 IPI:IPI00131999.2 
                 FELLPTPPLSPS*RR 
                 1513 
                 Myc 
                 myc proto-oncogene protein 
                 −1.219 
               
               
                   
               
               
                 IPI:IPI00282957.4 
                 EPAAPAS*PAPS*PVPSPT*P 
                 1514 
                 Mtap7d1 
                 Isoform 1 of MAP7 domain-containing 
                 −1.217 
               
               
                   
                 AQPQK 
                   
                   
                 protein 1 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGVT 
                 1515 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −1.212 
               
               
                   
                 SPTSDEPPMQASQSQLPSS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 PEDK 
               
               
                   
               
               
                 IPI:IPI00226220.2 
                 TFS*LDAAPADHSLGPSR{circumflex over ( )} 
                 1516 
                 Rtkn 
                 Isoform 1 of Rhotekin 
                 −1.207 
               
               
                   
               
               
                 IPI:IPI00318938.6 
                 NS*PVAKT*PPKDLPAIPGVT 
                 1517 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 −1.203 
               
               
                   
                 SPTSDEPPM#QASQSQLPS 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                 SPEDK 
               
               
                   
               
               
                 IPI:IPI00664670.4 
                 LGS*FGS*ITR{circumflex over ( )} 
                 1518 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 −1.194 
               
               
                   
               
               
                 IPI:IPI00473912.4 
                 NSTHSNLHTS*LGNS*VWG 
                 1519 
                 Gigyf2 
                 Isoform 1 of PERQ amino acid-rich with 
                 −1.193 
               
               
                   
                 SINT*GPS*NQWASELVSSI 
                   
                   
                 GYF domain-containing protein 2 
               
               
                   
                 WSNADTK 
               
               
                   
               
               
                 IPI:IPI00227380.1 
                 TRS*EPLPPSATASPLLAPL 
                 1520 
                 Hdac7 
                 Isoform 4 of Histone deacetylase 7 
                 −1.178 
               
               
                   
                 QPR 
               
               
                   
               
               
                 IPI:IPI00119442.1 
                 M#DTGEVSDIGSQGAPIVLS 
                 1521 
                 Exosc9 
                 Exosome complex exonuclease RRP45 
                 −1.177 
               
               
                   
                 *DS*EEEEMIILEPEK@NPK@ 
               
               
                   
               
               
                 IPI:IPI00119442.1 
                 M#DTGEVSDIGSQGAPIVLS 
                 1522 
                 Exosc9 
                 Exosome complex exonuclease RRP45 
                 −1.177 
               
               
                   
                 *DS*EEEEMIILEPEKNPK 
               
               
                   
               
               
                 IPI:IPI00119442.1 
                 MDTGEVSDIGSQGAPIVLS* 
                 1523 
                 Exosc9 
                 Exosome complex exonuclease RRP45 
                 −1.177 
               
               
                   
                 DS*EEEEM#IILEPEKNPK 
               
               
                   
               
               
                 IPI:IPI00221882.1 
                 DHNS*EDEDEDKYADDIDM 
                 1524 
                 Slu7 
                 Pre-mRNA-splicing factor SLU7 
                 −1.167 
               
               
                   
                 #PGQNFDSK 
               
               
                   
               
               
                 IPI:IPI00675346.2 
                 R{circumflex over ( )}QSGT*DLQEDVIVR{circumflex over ( )} 
                 1525 
                 Myo9a 
                 Isoform 2 of Myosin-IXa 
                 −1.166 
               
               
                   
               
               
                 IPI:IPI00125319.1 
                 TTS*FAESCKPVQQPSAFG 
                 1526 
                 Gsk3b 
                 Glycogen synthase kinase-3 beta 
                 −1.165 
               
               
                   
                 SMK 
               
               
                   
               
               
                 IPI:IPI00654192.2 
                 SLS*FSEPQQPPPTVK 
                 1527 
                 Zfp395 
                 zinc finger protein 395 
                 −1.165 
               
               
                   
               
               
                 IPI:IPI00128975.3 
                 DKDDQEWEST*SPPKPTVFI 
                 1528 
                 Dap 
                 Death-associated protein 1 
                 −1.165 
               
               
                   
                 SGVIAR 
               
               
                   
               
               
                 IPI:IPI00330897.1 
                 S*PVVITIDS*DS* 
                 1529 
                 Topors 
                 E3 ubiquitin-protein ligase Topors 
                 −1.161 
               
               
                   
                 DGESEVK@ 
               
               
                   
               
               
                 IPI:IPI00330133.2 
                 INDELEGLGLEGGS*EGEAPR 
                 1530 
                 Bend3 
                 BEN domain-containing protein 3 
                 −1.159 
               
               
                   
               
               
                 IPI:IPI00330133.2 
                 INDELEGLGLEGGS*EGEAPR 
                 1531 
                 Bend3 
                 BEN domain-containing protein 3 
                 −1.159 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 1532 
                 Npm1 
                 Nucleophosmin 
                 −1.157 
               
               
                   
                 AES*EDEDEEDVK@ 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 1533 
                 Npm1 
                 Nucleophosmin 
                 −1.157 
               
               
                   
                 AES*EDEDEEDVK 
               
               
                   
               
               
                 IPI:IPI00314749.2 
                 ISENYS*DKSDVENADESSS 
                 1534 
                 Slc4a4 
                 Isoform 1 of Electrogenic sodium 
                 −1.156 
               
               
                   
                 SILKPLISPAAER 
                   
                   
                 bicarbonate cotransporter 1 
               
               
                   
               
               
                 IPI:IPI00123709.1 
                 GPSEAPQEAEAEEGATS*D 
                 1535 
                 Akap12 
                 Isoform 1 of A-kinase anchor protein 12 
                 −1.154 
               
               
                   
                 GEK 
               
               
                   
               
               
                 IPI:IPI00321774.2 
                 HLLTDLPLPPELPGGDPS*P 
                 1536 
                 Crkrs 
                 Isoform 2 of Cell division cycle 2- 
                 −1.15 
               
               
                   
                 PDS*PEPK 
                   
                   
                 related protein kinase 7 
               
               
                   
               
               
                 IPI:IPI00420601.5 
                 SDLIEDEELEDTGKGS*EDE 
                 1537 
                 Usp10 
                 Ubiquitin carboxyl-terminal hydrolase 
                 −1.149 
               
               
                   
                 WEQVGPK 
                   
                   
                 10 
               
               
                   
               
               
                 IPI:IPI00421179.1 
                 EATLPPVS*PPK@ 
                 1538 
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation 
                 −1.146 
               
               
                   
                   
                   
                   
                 initiation factor 4 gamma 1 
               
               
                   
               
               
                 IPI:IPI00269136.2 
                 KGLVAASGS*DS*EDEDSM 
                 1539 
                 Tgif1 
                 Isoform 1 of Homeobox protein TGIF1 
                 −1.143 
               
               
                   
                 DSPLDLSSSAASGK 
               
               
                   
               
               
                 IPI:IPI00221581.1 
                 TGS*ESSQTGASATSGR 
                 1540 
                 Eif4b 
                 Eukaryotic translation initiation 
                 −1.142 
               
               
                   
                   
                   
                   
                 factor 4B 
               
               
                   
               
               
                 IPI:IPI00756765.3 
                 ALVIQESESPPS*PPPS*PDR 
                 1541 
                 Ehmt2 
                 Euchromatic histone lysine N- 
                 −1.141 
               
               
                   
                 {circumflex over ( )}R{circumflex over ( )} 
                   
                   
                 methyltransferase 2 
               
               
                   
               
               
                 IPI:IPI00137668.1 
                 M#LPHAPGVQM#QAIPEDA 
                 1542 
                 Hdac2 
                 Histone deacetylase 2 
                 −1.123 
               
               
                   
                 VHEDS*GDEDGEDPDKR 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 IHTTALTGQS*PPLASGHQG 
                 1543 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.123 
               
               
                   
                 EGDAPSVEPGATNIQQPSS* 
                   
                   
                 matrix protein 2 
               
               
                   
                 PAPSTK@ 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 IHTTALTGQS*PPLASGHQG 
                 1544 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.123 
               
               
                   
                 EGDAPSVEPGATNIQQPSS* 
                   
                   
                 matrix protein 2 
               
               
                   
                 PAPSTK 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 IHTTALTGQSPPLASGHQG 
                 1545 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.123 
               
               
                   
                 EGDAPS*VEPGATNIQQPSS 
                   
                   
                 matrix protein 2 
               
               
                   
                 *PAPSTK 
               
               
                   
               
               
                 IPI:IPI00339428.9 
                 MSSHT*ETSSFLQTLTGR{circumflex over ( )} 
                 1546 
                 Dock7 
                 Isoform 2 of Dedicator of cytokinesis 
                 −1.12 
               
               
                   
                   
                   
                   
                 protein 7 
               
               
                   
               
               
                 IPI:IPI00339428.9 
                 MS*SHTETSSFLQTLTGR{circumflex over ( )} 
                 1547 
                 Dock7 
                 Isoform 2 of Dedicator of cytokinesis 
                 −1.12 
               
               
                   
                   
                   
                   
                 protein 7 
               
               
                   
               
               
                 IPI:IPI00339428.9 
                 MS*SHTETSSFLQTLTGR 
                 1548 
                 Dock7 
                 Isoform 2 of Dedicator of cytokinesis 
                 −1.12 
               
               
                   
                   
                   
                   
                 protein 7 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 1549 
                 Npm1 
                 Nucleophosmin 
                 −1.119 
               
               
                   
                 AES*EDEDEEDVK@ 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 1550 
                 Npm1 
                 Nucleophosmin 
                 −1.119 
               
               
                   
                 AES*EDEDEEDVK@ 
               
               
                   
               
               
                 IPI:IPI00331361.2 
                 S*PSLLQSGVK 
                 1551 
                 Mybbp1a 
                 Myb-binding protein 1A 
                 −1.116 
               
               
                   
               
               
                 IPI:IPI00309059.7 
                 ST*S*PIIGSPPVR{circumflex over ( )} 
                 1552 
                 Patl1 
                 Protein PAT1 homolog 1 
                 −1.115 
               
               
                   
               
               
                 IPI:IPI00339428.9 
                 MSSHTETS*SFLQTLTGR{circumflex over ( )} 
                 1553 
                 Dock7 
                 Isoform 2 of Dedicator of cytokinesis 
                 −1.114 
               
               
                   
                   
                   
                   
                 protein 7 
               
               
                   
               
               
                 IPI:IPI00123747.1 
                 LPS*M#GDQEPPGQEK 
                 1554 
                 Slc7a11 
                 Cystine/glutamate transporter 
                 −1.114 
               
               
                   
               
               
                 IPI:IPI00322095.4 
                 IDEPNTPYHNMIGDDEDAYS 
                 1555 
                 Ppp1r2 
                 Putative uncharacterized protein 
                 −1.107 
               
               
                   
                 DS*EGNEVM#TPDILAK 
               
               
                   
               
               
                 IPI:IPI00135379.3 
                 LSEGEPGPVAAGEQLSEHP 
                 1556 
                 Myo9b 
                 Isoform 1 of Myosin-IXb 
                 −1.106 
               
               
                   
                 VEDPESLGVEAETWMNKS* 
               
               
                   
                 PDGMS*PK 
               
               
                   
               
               
                 IPI:IPI00125319.1 
                 TTS*FAESCKPVQQPSAFG 
                 1557 
                 Gsk3b 
                 Glycogen synthase kinase-3 beta 
                 −1.105 
               
               
                   
                 SMK 
               
               
                   
               
               
                 IPI:IPI00125319.1 
                 TTS*FAESCK@PVQQPSAF 
                 1558 
                 Gsk3b 
                 Glycogen synthase kinase-3 beta 
                 −1.105 
               
               
                   
                 GSMK@ 
               
               
                   
               
               
                 IPI:IPI00125319.1 
                 TTS*FAESCKPVQQPSAFG 
                 1559 
                 Gsk3b 
                 Glycogen synthase kinase-3 beta 
                 −1.103 
               
               
                   
                 SMK 
               
               
                   
               
               
                 IPI:IPI00320208.3 
                 YGPSSVEDTTGSGAADAKD 
                 1560 
                 Eef1b2 
                 Elongation factor 1-beta 
                 −1.102 
               
               
                   
                 DDDIDLFGS*DDEEESEEAKK 
               
               
                   
               
               
                 IPI:IPI00331361.2 
                 SPAPSNPTLS*PS*TPAK@T 
                 1561 
                 Mybbp1a 
                 Myb-binding protein 1A 
                 −1.101 
               
               
                   
                 PK@ 
               
               
                   
               
               
                 IPI:IPI00331361.2 
                 SPAPSNPTLS*PST*PAKTPK 
                 1562 
                 Mybbp1a 
                 Myb-binding protein 1A 
                 −1.101 
               
               
                   
               
               
                 IPI:IPI00668709.2 
                 SSS*APNVHINTI 
                 1563 
                 Braf 
                 B-Raf protein 
                 −1.097 
               
               
                   
                 EPVNIDDLIR 
               
               
                   
               
               
                 IPI:IPI00462466.6 
                 K@LDES*PVLK@PEFIGHD 
                 1564 
                 Setd2 
                 SET domain containing 2 
                 −1.096 
               
               
                   
                 GR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00462466.6 
                 KLDES*PVLKPEFIGHDGR 
                 1565 
                 Setd2 
                 SET domain containing 2 
                 −1.096 
               
               
                   
               
               
                 IPI:IPI00108389.5 
                 LLDGPTGS*S*EEEEEFLEIP 
                 1566 
                 Trp53bp1 
                 Transformation related protein 53 
                 −1.094 
               
               
                   
                 PFNK 
                   
                   
                 binding protein 1 
               
               
                   
               
               
                 IPI:IPI00668709.2 
                 SSS*APNVHINTIEP 
                 1567 
                 Braf 
                 B-Raf protein 
                 −1.088 
               
               
                   
                 VNIDDLIR 
               
               
                   
               
               
                 IPI:IPI00225062.2 
                 DGSGT*PSRHSLS*GSS*PG 
                 1568 
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive 
                 −1.081 
               
               
                   
                 M#KDTPQT*PSR 
                   
                   
                 matrix protein 2 
               
               
                   
               
               
                 IPI:IPI00135971.1 
                 VQIPVSHPDPEPVS*DNEDD 
                 1569 
                 Tjp1 
                 Tight junction protein ZO-1 
                 −1.08 
               
               
                   
                 S*YDEEVHDPR 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 1570 
                 Npm1 
                 Nucleophosmin 
                 −1.077 
               
               
                   
                 AES*EDEDEEDVK 
               
               
                   
               
               
                 IPI:IPI00111169.1 
                 HIVSNDSSDS*DDEAQGPK@ 
                 1571 
                 Pla2g4a 
                 Cytosolic phospholipase A2 
                 −1.072 
               
               
                   
               
               
                 IPI:IPI00225670.1 
                 EVHDELEDLPS*PPPPLSPP 
                 1572 
                 Gphn 
                 Gephyrin 
                 −1.07 
               
               
                   
                 PT*TSPHK 
               
               
                   
               
               
                 IPI:IPI00225670.1 
                 EVHDELEDLPS*PPPPLS*P 
                 1573 
                 Gphn 
                 Gephyrin 
                 −1.07 
               
               
                   
                 PPTTSPHK@ 
               
               
                   
               
               
                 IPI:IPI00123709.1 
                 AEDS*GAEQLASEIEPSR 
                 1574 
                 Akap12 
                 Isoform 1 of A-kinase anchor protein 12 
                 −1.067 
               
               
                   
               
               
                 IPI:IPI00123709.1 
                 AEDS*GAEQLASEIEPSR 
                 1575 
                 Akap12 
                 Isoform 1 of A-kinase anchor protein 12 
                 −1.067 
               
               
                   
               
               
                 IPI:IPI00454109.2 
                 S*PPACSSSSSSLFSAVVAR{circumflex over ( )} 
                 1576 
                 Erf 
                 ETS domain-containing transcription 
                 −1.066 
               
               
                   
                   
                   
                   
                 factor ERF 
               
               
                   
               
               
                 IPI:IPI00313517.1 
                 GPPS*EDEGMDIHFEEGVLS 
                 1577 
                   
                   
                 −1.066 
               
               
                   
                 PSAADMR{circumflex over ( )}PEPPNSLDLNG 
               
               
                   
                 SHPR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00313517.1 
                 GPPS*EDEGMDIHFEEGVLS 
                 1578 
                   
                   
                 −1.066 
               
               
                   
                 PSAADMRPEPPNSLDLNGS 
               
               
                   
                 HPR 
               
               
                   
               
               
                 IPI:IPI00311375.6 
                 S*GITSLLFGEDDLEALK 
                 1579 
                 Sgsm3 
                 small G protein signaling modulator 3 
                 −1.061 
               
               
                   
               
               
                 IPI:IPI00311490.4 
                 VLS*DS*EEEEKDADVPGTS 
                 1580 
                 Phip 
                 PH-interacting protein 
                 −1.059 
               
               
                   
                 TR 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 GHYEVT*GSDDEAGKLQGS 
                 1581 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 −1.057 
               
               
                   
                 GVSLASK 
               
               
                   
               
               
                 IPI:IPI00553798.2 
                 GHYEVTGS*DDEAGK@LQ 
                 1582 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 −1.057 
               
               
                   
                 GSGVSLASK@ 
               
               
                   
               
               
                 IPI:IPI00336281.1 
                 RDSICS*SVSMESSLAEPQD 
                 1583 
                 Golga3 
                 Isoform 1 of Golgin subfamily A 
                 −1.056 
               
               
                   
                 ELLQILK 
                   
                   
                 member 3 
               
               
                   
               
               
                 IPI:IPI00229859.1 
                 ALENGEADEPS*FS*DPEDF 
                 1584 
                 Eif3b 
                 Eif3b protein 
                 −1.053 
               
               
                   
                 VDDVSEEELLGDVLK 
               
               
                   
               
               
                 IPI:IPI00668709.2 
                 DRSSS*APNVHINTIEPVNID 
                 1585 
                 Braf 
                 B-Raf protein 
                 −1.048 
               
               
                   
                 DLIR 
               
               
                   
               
               
                 IPI:IPI00668709.2 
                 DR{circumflex over ( )}SSS*APNVHINTIEPVNI 
                 1586 
                 Braf 
                 B-Raf protein 
                 −1.048 
               
               
                   
                 DDLIR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00125319.1 
                 T*TSFAESCKPVQQPSAFG 
                 1587 
                 Gsk3b 
                 Glycogen synthase kinase-3 beta 
                 −1.047 
               
               
                   
                 SMK 
               
               
                   
               
               
                 IPI:IPI00135660.5 
                 RGNNSAVGS*NADLT*IEED 
                 1588 
                 Sdpr 
                 Serum deprivation-response protein 
                 −1.046 
               
               
                   
                 EEEEPVALQQAQQVR 
               
               
                   
               
               
                 IPI:IPI00339428.9 
                 MSS*HTETSSFLQTLTGR 
                 1589 
                 Dock7 
                 Isoform 2 of Dedicator of cytokinesis 
                 −1.042 
               
               
                   
                   
                   
                   
                 protein 7 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 1590 
                 Npm1 
                 Nucleophosmin 
                 −1.039 
               
               
                   
                 AES*EDEDEEDVK 
               
               
                   
               
               
                 IPI:IPI00115660.1 
                 GPILAT*PGK@ 
                 1591 
                 Tcof1 
                 Treacle protein 
                 −1.038 
               
               
                   
               
               
                 IPI:IPI00115660.1 
                 GPILAT*PGK 
                 1592 
                 Tcof1 
                 Treacle protein 
                 −1.038 
               
               
                   
               
               
                 IPI:IPI00115660.1 
                 GPILAT*PGK 
                 1593 
                 Tcof1 
                 Treacle protein 
                 −1.038 
               
               
                   
               
               
                 IPI:IPI00115660.1 
                 GPILAT*PGK@ 
                 1594 
                 Tcof1 
                 Treacle protein 
                 −1.038 
               
               
                   
               
               
                 IPI:IPI00230704.4 
                 KES*APQVLLPEEEK 
                 1595 
                 Arhgef7 
                 Isoform C of Rho guanine nucleotide 
                 −1.036 
               
               
                   
                   
                   
                   
                 exchange factor 7 
               
               
                   
               
               
                 IPI:IPI00320422.3 
                 LQEEGGS*EEEEAGNPSED 
                 1596 
                 Pwp1 
                 Periodic tryptophan protein 1 homolog 
                 −1.035 
               
               
                   
                 GM#QSGPTQAPPR 
               
               
                   
               
               
                 IPI:IPI00270767.3 
                 VVKEDGVM#S*PEK 
                 1597 
                 Rtn4 
                 Isoform 2 of Reticulon-4 
                 −1.035 
               
               
                   
               
               
                 IPI:IPI00331306.7 
                 ARQPSQADTGEEDSDEDY* 
                 1598 
                 Sh3bp2 
                 SH3-domain binding protein 2 isoform c 
                 −1.034 
               
               
                   
                 EKVPLPNSVFVNTTESCEV 
               
               
                   
                 ER 
               
               
                   
               
               
                 IPI:IPI00137864.1 
                 YDLSNQDHIMDAPPLS*PFP 
                 1599 
                 Rbl1 
                 Isoform Long of Retinoblastoma-like 
                 −1.03 
               
               
                   
                 HIK@ 
                   
                   
                 protein 1 
               
               
                   
               
               
                 IPI:IPI00137864.1 
                 YDLSNQDHIMDAPPLS*PFP 
                 1600 
                 Rbl1 
                 Isoform Long of Retinoblastoma-like 
                 −1.03 
               
               
                   
                 HIK 
                   
                   
                 protein 1 
               
               
                   
               
               
                 IPI:IPI00320208.3 
                 YGPSSVEDTTGSGAADAK 
                 1601 
                 Eef1b2 
                 Elongation factor 1-beta 
                 −1.028 
               
               
                   
                 @DDDDIDLFGS*DDEEESE 
               
               
                   
                 EAK@K@ 
               
               
                   
               
               
                 IPI:IPI00404545.2 
                 SLS*S*PTVTLSAPLEGAK 
                 1602 
                 Nedd4l 
                 Isoform 3 of E3 ubiquitin-protein 
                 −1.027 
               
               
                   
                   
                   
                   
                 ligase NEDD4-like 
               
               
                   
               
               
                 IPI:IPI00127764.2 
                 VIEDEDGAAAAATVSNSEET 
                 1603 
                 Pcm1 
                 Isoform 1 of Pericentriolar material 1 
                 −1.024 
               
               
                   
                 PIIENHNS*PQPISDVSAVPC 
                   
                   
                 protein 
               
               
                   
                 PR{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00131884.1 
                 TT*PAPS*PGS*ANESFFAPS 
                 1604 
                 Mid1ip1 
                 Mid1-interacting protein 1 
                 −1.024 
               
               
                   
                 R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00131884.1 
                 TT*PAPS*PGS*ANESFFAPS 
                 1605 
                 Mid1ip1 
                 Mid1-interacting protein 1 
                 −1.024 
               
               
                   
                 R{circumflex over ( )} 
               
               
                   
               
               
                 IPI:IPI00131884.1 
                 TT*PAPS*PGS*ANESF 
                 1606 
                 Mid1ip1 
                 Mid1-interacting protein 1 
                 −1.024 
               
               
                   
                 FAPSR 
               
               
                   
               
               
                 IPI:IPI00400381.9 
                 LGST*GS*QPNSEAEPGPEH 
                 1607 
                 Phactr4 
                 Isoform 1 of Phosphatase and actin 
                 −1.02 
               
               
                   
                 APK 
                   
                   
                 regulator 4 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 1608 
                 Npm1 
                 Nucleophosmin 
                 −1.018 
               
               
                   
                 AES*EDEDEEDVK 
               
               
                   
               
               
                 IPI:IPI00756765.3 
                 ALVIQESESPPS*PPPS*PDR 
                 1609 
                 Ehmt2 
                 Euchromatic histone lysine N- 
                 −1.017 
               
               
                   
                 {circumflex over ( )}R{circumflex over ( )} 
                   
                   
                 methyltransferase 2 
               
               
                   
               
               
                 IPI:IPI00136917.5 
                 TDQEGLNASQPT*PPPLPK@ 
                 1610 
                 C230081A13Rik 
                 Tyrosine-protein kinase-protein kinase 
                 −1.016 
               
               
                   
               
               
                 IPI:IPI00127415.1 
                 CGSGPVHISGQHLVAVEED 
                 1611 
                 Npm1 
                 Nucleophosmin 
                 −1.015 
               
               
                   
                 AES*EDEDEEDVK 
               
               
                   
               
               
                 IPI:IPI00453673.4 
                 RAS*DGGANIQLHAQQLLK 
                 1612 
                 BC033915 
                 serine/threonine-protein kinase QSK 
                 −1.015 
               
               
                   
               
               
                 IPI:IPI00453837.2 
                 KLPPPPPQAPPEEENES*EP 
                 1613 
                 Kdm1 
                 Lysine-specific histone demethylase 1 
                 −1.014 
               
               
                   
                 EEPSGVEGAAFQSR 
               
               
                   
               
               
                 IPI:IPI00227900.1 
                 FKGPGDTSNFDDYEEEEIR 
                 1614 
                 Prkaca 
                 Isoform 2 of cAMP-dependent protein 
                 −1.01 
               
               
                   
                 VS*INEK 
                   
                   
                 kinase catalytic subunit alpha 
               
               
                   
               
               
                 IPI:IPI00125662.2 
                 VDPTYGLESSCIAGTGPDE 
                 1615 
                 Smarcc1 
                 Isoform 1 of SWI/SNF complex subunit 
                 −1.007 
               
               
                   
                 PEK@LEGS*EEEK@M#ETD 
                   
                   
                 SMARCC1 
               
               
                   
                 PDGQQPEK@ 
               
               
                   
               
               
                 IPI:IPI00677756.1 
                 KLS*FSMPR 
                 1616 
                 Ahnak2 
                 Putative uncharacterized protein 
                 −1.006 
               
               
                   
               
               
                 IPI:IPI00395213.1 
                 LDFLPEMMVDHCS*LNSSP 
                 1617 
                 Cugbp1 
                 Isoform 4 of CUG-BP- and ETR-3-like 
                 −1.002 
               
               
                   
                 VSK@K@ 
                   
                   
                 factor 1 
               
               
                   
               
               
                 Table 8. Gene names and sequences of the phosphopeptides whose intensities decrease after Ku-0063794 treatment. Note that the light cells were treated with rapamycin and serve as controls whereas the heavy cells were treated with a combination of rapamycin and Ku-0063794. 
               
            
           
         
       
     
     
       
         
           
               
             
               
                   
               
             
            
               
                 Table 9(a) 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                 SEQ ID 
                 Gene 
                   
                   
               
               
                 ID 
                 Reference 
                 Ascore Seq 
                 NO 
                 Name 
                 Annotation 
                 Class 
               
               
                   
               
               
                  1 
                 IPI:IPI00121418.1 
                 DGEGPDNLEPACPLSLPLQ 
                 1618 
                 Rb1 
                 Retinoblastoma-associated 
                 1 
               
               
                   
                   
                 GNHTAADMYLS*PLRS*PK 
                   
                   
                 protein 
               
               
                   
               
               
                  2 
                 IPI:IPI00221581.1 
                 TGS*ESS*QTGASATSGR 
                 1619 
                 Eif4b 
                 Eukaryotic translation initiation 
                 1 
               
               
                   
                   
                   
                   
                   
                 factor 4B 
               
               
                   
               
               
                  3 
                 IPI:IPI00929786.1 
                 T*ASISSS*PSEGTPAVGSY 
                 1620 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 1 
               
               
                   
                   
                 GCT*PQS*LPK@ 
               
               
                   
               
               
                  4 
                 IPI:IPI00929786.1 
                 T*ASISSS*PSEGTPAVGSY* 
                 1621 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 1 
               
               
                   
                   
                 GCT*PQSLPK@ 
               
               
                   
               
               
                  5 
                 IPI:IPI00929786.1 
                 T*ASISSS*PSEGTPAVGS*Y 
                 1622 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 1 
               
               
                   
                   
                 GCTPQSLPK@ 
               
               
                   
               
               
                  6 
                 IPI:IPI00317401.6 
                 AES*PETSAVESTQST*PQK@ 
                 1623 
                 Pds5b 
                 Isoform 1 of Sister chromatid 
                 1 
               
               
                   
                   
                   
                   
                   
                 cohesion protein PDS5 homolog B 
               
               
                   
               
               
                  7 
                 IPI:IPI00107958.1 
                 TSDIFGS*PVTATAPLAHPN 
                 1624 
                 Hn1l 
                 Hematological and neurological 
                 1 
               
               
                   
                   
                 K@PK@ 
                   
                   
                 expressed 1-like protein 
               
               
                   
               
               
                  8 
                 IPI:IPI00108454.2 
                 R{circumflex over ( )}LS*S*LR{circumflex over ( )} 
                 1625 
                 Rps6 
                 29 kDa protein 
                 1 
               
               
                   
               
               
                  9 
                 IPI:IPI00225062.2 
                 R{circumflex over ( )}SSS*ELS*PEVVEK@ 
                 1626 
                 Srrm2 
                 Isoform 3 of Serine/arginine 
                 1 
               
               
                   
                   
                   
                   
                   
                 repetitive matrix protein 2 
               
               
                   
               
               
                 10 
                 IPI:IPI00761759.1 
                 S*SS*GS*EHSTEGSVSLGD 
                 1627 
                 Larp4 
                 Putative uncharacterized protein 
                 1 
               
               
                   
                   
                 GPLSR{circumflex over ( )} 
               
               
                   
               
               
                 11 
                 IPI:IPI00761759.1 
                 SSS*GSEHS*T*EGSVSLGD 
                 1628 
                 Larp4 
                 Putative uncharacterized protein 
                 1 
               
               
                   
                   
                 GPLSR{circumflex over ( )} 
               
               
                   
               
               
                 12 
                 IPI:IPI00225062.2 
                 RSS*SELS*PEVVEK 
                 1629 
                 Srrm2 
                 Isoform 3 of Serine/arginine 
                 1 
               
               
                   
                   
                   
                   
                   
                 repetitive matrix protein 2 
               
               
                   
               
               
                 13 
                 IPI:IPI00122594.4 
                 TTPLAS*PSLS*PGR{circumflex over ( )} 
                 1630 
                 Ahctf1 
                 AT-hook-containing transcription 
                 1 
               
               
                   
                   
                   
                   
                   
                 factor 1 
               
               
                   
               
               
                 14 
                 IPI:IPI00136107.1 
                 THS*TSS*S*IGSGESPFSR{circumflex over ( )} 
                 1631 
                 Ndrg3 
                 Protein NDRG3 
                 1 
               
               
                   
               
               
                 15 
                 IPI:IPI00136107.1 
                 THS*TSSS*IGSGESPFSR{circumflex over ( )} 
                 1632 
                 Ndrg3 
                 Protein NDRG3 
                 1 
               
               
                   
               
               
                 16 
                 IPI:IPI00136107.1 
                 THS*TSS*SIGSGESPFSR{circumflex over ( )} 
                 1633 
                 Ndrg3 
                 Protein NDRG3 
                 1 
               
               
                   
               
               
                 17 
                 IPI:IPI00136107.1 
                 THS*TSSSIGSGESPFSR{circumflex over ( )} 
                 1634 
                 Ndrg3 
                 Protein NDRG3 
                 1 
               
               
                   
               
               
                 18 
                 IPI:IPI00136107.1 
                 T*HST*SSS*IGSGESPFSR{circumflex over ( )} 
                 1635 
                 Ndrg3 
                 Protein NDRG3 
                 1 
               
               
                   
               
               
                 19 
                 IPI:IPI00136107.1 
                 THST*SSS*IGSGESPFSR{circumflex over ( )} 
                 1636 
                 Ndrg3 
                 Protein NDRG3 
                 1 
               
               
                   
               
               
                 20 
                 IPI:IPI00136107.1 
                 THSTSS*S*IGSGESPFSR{circumflex over ( )} 
                 1637 
                 Ndrg3 
                 Protein NDRG3 
                 1 
               
               
                   
               
               
                 21 
                 IPI:IPI00136107.1 
                 T*HSTSSSIGS*GESPFSR{circumflex over ( )} 
                 1638 
                 Ndrg3 
                 Protein NDRG3 
                 1 
               
               
                   
               
               
                 22 
                 IPI:IPI00136107.1 
                 THST*SSSIGSGESPFSR{circumflex over ( )} 
                 1639 
                 Ndrg3 
                 Protein NDRG3 
                 1 
               
               
                   
               
               
                 23 
                 IPI:IPI00551454.3 
                 ER{circumflex over ( )}QES*ESEQELVNK@ 
                 1640 
                 Pdcd11 
                 Protein RRP5 homolog 
                 1 
               
               
                   
               
               
                 24 
                 IPI:IPI00117229.3 
                 TS*PAGGTWSSVVSGVPR 
                 1641 
                 Atxn2 
                 ataxin 2 
                 1 
               
               
                   
               
               
                 25 
                 IPI:IPI00348442.1 
                 SK@FDS*DEEDEDAENLEA 
                 1642 
                 Sfrs18 
                 splicing factor arginine/serine-rich 
                 1 
               
               
                   
                   
                 VSSGK@ 
                   
                   
                 18 
               
               
                   
               
               
                 26 
                 IPI:IPI00556837.1 
                 DTVIIVS*EPS*EDEESHDLP 
                 1643 
                 Smarcad1 
                 Isoform 1 of SWI/SNF-related 
                 1 
               
               
                   
                   
                 SVTR 
                   
                   
                 matrix-associated actin- 
               
               
                   
                   
                   
                   
                   
                 dependent regulator of chromatin 
               
               
                   
                   
                   
                   
                   
                 subfamily A containing DEAD/H 
               
               
                   
                   
                   
                   
                   
                 box 1 
               
               
                   
               
               
                 27 
                 IPI:IPI00153986.2 
                 GTS*RPGT*PSAEAASTSST 
                 1644 
                 Gtf2f1 
                 General transcription factor IIF 
                 1 
               
               
                   
                   
                 LR 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 28 
                 IPI:IPI00225062.2 
                 GCS*PPKS*PEKPPQSTSS* 
                 1645 
                 Srrm2 
                 Isoform 3 of Serine/arginine 
                 1 
               
               
                   
                   
                 ESCPPSPQPTK 
                   
                   
                 repetitive matrix protein 2 
               
               
                   
               
               
                 29 
                 IPI:IPI00128904.1 
                 VMTIPYQPMPASS*PVICAG 
                 1646 
                 Pcbp1 
                 Poly(rC)-binding protein 1 
                 1 
               
               
                   
                   
                 GQDR 
               
               
                   
               
               
                 30 
                 IPI:IPI00121251.7 
                 LSTTPS*PTNS*LHEDGVDD 
                 1647 
                 Tox4 
                 TOX high mobility group box 
                 1 
               
               
                   
                   
                 FRR 
                   
                   
                 family member 4 
               
               
                   
               
               
                 31 
                 IPI:IPI00320594.5 
                 SQPHSSTSNQETS*DS*EM 
                 1648 
                 Ranbp10 
                 Ran-binding protein 10 
                 1 
               
               
                   
                   
                 EMEAEHYPNGVLESVSTR{circumflex over ( )} 
               
               
                   
               
               
                 32 
                 IPI:IPI00808277.2 
                 SAPAS*PNHAGVLSAHSSG 
                 1649 
                 Foxk2 
                 Isoform 1 of Forkhead box 
                 1 
               
               
                   
                   
                 AQT*PES*LSR{circumflex over ( )} 
                   
                   
                 protein K2 
               
               
                   
               
               
                 33 
                 IPI:IPI00137166.1 
                 SR{circumflex over ( )}DAT*PPVS*PINMEDQE 
                 1650 
                 Junb 
                 Transcription factor jun-B 
                 1 
               
               
                   
                   
                 R{circumflex over ( )} 
               
               
                   
               
               
                 34 
                 IPI:IPI00454104.1 
                 TTEAPCSPGS*QQPPS*PD 
                 1651 
                 Scrib 
                 Isoform 1 of Protein LAP4 
                 1 
               
               
                   
                   
                 ELPANVK@ 
               
               
                   
               
               
                 35 
                 IPI:IPI00225062.2 
                 GCS*PPK@S*PEK@PPQST 
                 1652 
                 Srrm2 
                 Isoform 3 of Serine/arginine 
                 1 
               
               
                   
                   
                 SSESCPPS*PQPTK@ 
                   
                   
                 repetitive matrix protein 2 
               
               
                   
               
               
                 36 
                 IPI:IPI00153986.2 
                 GTSR{circumflex over ( )}PGT*PS*AEAASTSS 
                 1653 
                 Gtf2f1 
                 General transcription factor IIF 
                 1 
               
               
                   
                   
                 TLR{circumflex over ( )} 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 37 
                 IPI:IPI00753321.2 
                 SVSET*SEDK@K@DEES*D 
                 1654 
                 Bod1l 
                 biorientation of chromosomes in 
                 1 
               
               
                   
                   
                 EEEEEEEEEEPLGATTR{circumflex over ( )} 
                   
                   
                 cell division 1-like 
               
               
                   
               
               
                 38 
                 IPI:IPI00153986.2 
                 GT*SR{circumflex over ( )}PGT*PSAEAASTSS 
                 1655 
                 Gtf2f1 
                 General transcription factor IIF 
                 1 
               
               
                   
                   
                 TLR{circumflex over ( )} 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 39 
                 IPI:IPI00153986.2 
                 GTS*R{circumflex over ( )}PGTPS*AEAASTSS 
                 1656 
                 Gtf2f1 
                 General transcription factor IIF 
                 1 
               
               
                   
                   
                 TLR{circumflex over ( )} 
                   
                   
                 subunit 1 
               
               
                   
               
               
                 40 
                 IPI:IPI00929786.1 
                 TASIS*S*SPSEGTPAVGSY 
                 1657 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 1 
               
               
                   
                   
                 GCT*PQSLPK@ 
               
               
                   
               
               
                 41 
                 IPI:IPI00929786.1 
                 TAS*ISSS*PSEGTPAVGSY 
                 1658 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 1 
               
               
                   
                   
                 GCT*PQS*LPK@ 
               
               
                   
               
               
                 42 
                 IPI:IPI00130920.1 
                 RSES*PFEGK 
                 1659 
                 Mtap1b 
                 Microtubule-associated protein 
                 1 
               
               
                   
                   
                   
                   
                   
                 1B 
               
               
                   
               
               
                 43 
                 IPI:IPI00336973.2 
                 GLNLDGTPALSTLGGFS*PA 
                 1660 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1 
               
               
                   
                   
                 SK@PS*SPR{circumflex over ( )} 
               
               
                   
               
               
                 44 
                 IPI:IPI00336973.2 
                 GLNLDGTPALSTLGGFS*PA 
                 1661 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1 
               
               
                   
                   
                 S*KPSSPR 
               
               
                   
               
               
                 45 
                 IPI:IPI00336973.2 
                 GLNLDGT*PALSTLGGFS*P 
                 1662 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1 
               
               
                   
                   
                 ASK@PS*SPR{circumflex over ( )} 
               
               
                   
               
               
                 46 
                 IPI:IPI00336973.2 
                 GLNLDGTPALSTLGGFSPA 
                 1663 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1 
               
               
                   
                   
                 S*K@PS*SPR{circumflex over ( )} 
               
               
                   
               
               
                 47 
                 IPI:IPI00379844.4 
                 TAS*EGDGGAAGGAGTAG 
                 1664 
                 Irs2 
                 Insulin receptor substrate 2 
                 1 
               
               
                   
                   
                 GR{circumflex over ( )}PMSVAGS*PLS*PGPV 
               
               
                   
                   
                 R{circumflex over ( )} 
               
               
                   
               
               
                 48 
                 IPI:IPI00336973.2 
                 GLNLDGTPALSTLGGFS*PA 
                 1665 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1 
               
               
                   
                   
                 SKPSS*PR 
               
               
                   
               
               
                 49 
                 IPI:IPI00336973.2 
                 GLNLDGT*PALSTLGGFS*P 
                 1666 
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
                 1 
               
               
                   
                   
                 ASKPSS*PR 
               
               
                   
               
               
                 50 
                 IPI:IPI00656285.2 
                 SLVS*PIPS*PTGTISVPNSC 
                 1667 
                 Foxk1 
                 Forkhead box protein K1 
                 1 
               
               
                   
                   
                 PAS*PR{circumflex over ( )} 
               
               
                   
               
               
                 51 
                 IPI:IPI00656285.2 
                 SLVSPIPSPT*GT*ISVPNSC 
                 1668 
                 Foxk1 
                 Forkhead box protein K1 
                 1 
               
               
                   
                   
                 PAS*PR 
               
               
                   
               
               
                 52 
                 IPI:IPI00454104.1 
                 TTEAPCS*PGSQQPPS*PD 
                 1669 
                 Scrib 
                 Isoform 1 of Protein LAP4 
                 1 
               
               
                   
                   
                 ELPANVK@ 
               
               
                   
               
               
                 53 
                 IPI:IPI00753321.2 
                 S*VSETSEDK@K@DEES*D 
                 1670 
                 Bod1l 
                 biorientation of chromosomes in 
                 1 
               
               
                   
                   
                 EEEEEEEEEEPLGATTR{circumflex over ( )} 
                   
                   
                 cell division 1-like 
               
               
                   
               
               
                 54 
                 IPI:IPI00753321.2 
                 SVSETS*EDK@K@DEES*D 
                 1671 
                 Bod1l 
                 biorientation of chromosomes in 
                 1 
               
               
                   
                   
                 EEEEEEEEEEPLGATTR{circumflex over ( )} 
                   
                   
                 cell division 1-like 
               
               
                   
               
               
                 55 
                 IPI:IPI00313307.3 
                 SYQNS*PSS*EDGIR{circumflex over ( )}PLPE 
                 1672 
                 Med1 
                 Isoform 4 of Mediator of RNA 
                 1 
               
               
                   
                   
                 YSTEK@ 
                   
                   
                 polymerase II transcription 
               
               
                   
                   
                   
                   
                   
                 subunit 1 
               
               
                   
               
               
                 56 
                 IPI:IPI00225062.2 
                 GCS*PPK@S*PEK@PPQS* 
                 1673 
                 Srrm2 
                 Isoform 3 of Serine/arginine 
                 1 
               
               
                   
                   
                 TSSESCPPSPQPTK@ 
                   
                   
                 repetitive matrix protein 2 
               
               
                   
               
               
                 57 
                 IPI:IPI00318938.6 
                 NS*PVAK@TPPK@DLPAIP 
                 1674 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 1 
               
               
                   
                   
                 GVTSPTS*DEPPMQASQSQ 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
                   
                 LPSSPEDK@ 
               
               
                   
               
               
                 58 
                 IPI:IPI00130920.1 
                 SLMSS*PEDLTK@DFEELK 
                 1675 
                 MtaP1b 
                 Microtubule-associated protein 
                 1 
               
               
                   
                   
                 @AEEIDVAK@ 
                   
                   
                 1B 
               
               
                   
               
               
                 59 
                 IPI:IPI00553798.2 
                 SS*EVVLS*GDDEDYQR{circumflex over ( )} 
                 1676 
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
                 1 
               
               
                   
               
               
                 60 
                 IPI:IPI00129264.1 
                 ATSR{circumflex over ( )}PINLGPSS*PNTEIH 
                 1677 
                 Sorbs3 
                 Vinexin 
                 1 
               
               
                   
                   
                 WTPYR{circumflex over ( )} 
               
               
                   
               
               
                 61 
                 IPI:IPI00129264.1 
                 ATSRPINLGPS*SPNTEIHW 
                 1678 
                 Sorbs3 
                 Vinexin 
                 1 
               
               
                   
                   
                 TPYR 
               
               
                   
               
               
                 62 
                 IPI:IPI00123410.5 
                 TIS*AQDTLAYATALLNEK@ 
                 1679 
                 Usp24 
                 Isoform 1 of Ubiquitin carboxyl- 
                 1 
               
               
                   
                   
                   
                   
                   
                 terminal hydrolase 24 
               
               
                   
               
               
                 63 
                 IPI:IPI00226441.2 
                 LHYT*PPLQS*PIT*DGDPLL 
                 1680 
                 Lin9 
                 Isoform 2 of Lin-9 homolog 
                 1 
               
               
                   
                   
                 GQS*PWR{circumflex over ( )} 
               
               
                   
               
               
                 64 
                 IPI:IPI00309059.7 
                 STS*PIIGS*PPVR{circumflex over ( )} 
                 1681 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1 
               
               
                   
               
               
                 65 
                 IPI:IPI00336713.1 
                 CS*PVPGLSSS*PSGSPLHG 
                 1682 
                 Bcas3 
                 Isoform 1 of Breast carcinoma- 
                 1 
               
               
                   
                   
                 K@ 
                   
                   
                 amplified sequence 3 homolog 
               
               
                   
               
               
                 66 
                 IPI:IPI00320905.7 
                 LGEQGPEPGPT*PPQTPT* 
                 1683 
                 Arhgap17 
                 Isoform 1 of Rho GTPase- 
                 1 
               
               
                   
                   
                 PPS*TPPLAK 
                   
                   
                 activating protein 17 
               
               
                   
               
               
                 67 
                 IPI:IPI00309059.7 
                 R{circumflex over ( )}S*TS*PIIGS*PPVR{circumflex over ( )} 
                 1684 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1 
               
               
                   
               
               
                 68 
                 IPI:IPI00309059.7 
                 RSTS*PIIGS*PPVR 
                 1685 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1 
               
               
                   
               
               
                 69 
                 IPI:IPI00309059.7 
                 ST*S*PIIGS*PPVR{circumflex over ( )} 
                 1686 
                 Patl1 
                 Protein PAT1 homolog 1 
                 1 
               
               
                   
               
               
                 70 
                 IPI:IPI00317599.3 
                 SQEDEEEIST*SPGVSEFVS 
                 1687 
                 Syap1 
                 Synapse-associated protein 1 
                 1 
               
               
                   
                   
                 DAFDTCSLNQEDLRK 
               
               
                   
               
               
                 71 
                 IPI:IPI00317599.3 
                 SQEDEEEISTS*PGVSEFVS 
                 1688 
                 Syap1 
                 Synapse-associated protein 1 
                 1 
               
               
                   
                   
                 DAFDTCSLNQEDLRK 
               
               
                   
               
               
                 72 
                 IPI:IPI00656285.2 
                 SLVS*PIPSPT*GTISVPNS* 
                 1689 
                 Foxk1 
                 Forkhead box protein K1 
                 1 
               
               
                   
                   
                 CPASPR{circumflex over ( )} 
               
               
                   
               
               
                 73 
                 IPI:IPI00676574.2 
                 RVS*TDLPEGQDVYTAACN 
                 1690 
                 Herc1 
                 hect (homologous to the E6-AP 
                 1 
               
               
                   
                   
                 SVIHR 
                   
                   
                 (UBE3A) carboxyl terminus) 
               
               
                   
                   
                   
                   
                   
                 domain and RCC1 (CHC1)-like 
               
               
                   
                   
                   
                   
                   
                 domain (RLD) 1 
               
               
                   
               
               
                 74 
                 IPI:IPI00458958.2 
                 DWDK@ES*EGEEPAGGR{circumflex over ( )} 
                 1691 
                 Rrp15 
                 RRP15-like protein 
                 2 
               
               
                   
               
               
                 75 
                 IPI:IPI00230719.8 
                 R{circumflex over ( )}DS*SDDWEIPDGQITVGQ 
                 1692 
                 Braf 
                 Isoform 1 of B-Raf proto- 
                 2 
               
               
                   
                   
                 R{circumflex over ( )} 
                   
                   
                 oncogene serine/threonine- 
               
               
                   
                   
                   
                   
                   
                 protein kinase 
               
               
                   
               
               
                 76 
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1693 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 2 
               
               
                   
                   
                 GGTLFSTTPGGT*R 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 77 
                 IPI:IPI00874995.2 
                 AS*DDLGEPDVFATAPFR 
                 1694 
                 Aak1 
                 Uncharacterized protein 
                 2 
               
               
                   
                   
                   
                   
                   
                 FLJ45252 homolog 
               
               
                   
               
               
                 78 
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTT*P 
                 1695 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 2 
               
               
                   
                   
                 GGTLFSTT*PGGTR{circumflex over ( )} 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 79 
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYSTTPG 
                 1696 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 2 
               
               
                   
                   
                 GT*LFSTT*PGGTR 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 80 
                 IPI:IPI00318938.6 
                 VALGDGVQLPPGDYS*TTP 
                 1697 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 2 
               
               
                   
                   
                 GGTLFSTT*PGGTR{circumflex over ( )} 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 81 
                 IPI:IPI00323045.3 
                 S*MDVDLNQAHMEDTPK@ 
                 1698 
                 Melk 
                 Maternal embryonic leucine 
                 2 
               
               
                   
                   
                   
                   
                   
                 zipper kinase 
               
               
                   
               
               
                 82 
                 IPI:IPI00623284.4 
                 IWDPTPS*HTPAGAAT*PGR 
                 1699 
                 Sf3b1 
                 Splicing factor 3B subunit 1 
                 2 
               
               
                   
                   
                 GDT*PGHAT*PGHGGATSS 
               
               
                   
                   
                 AR 
               
               
                   
               
               
                 83 
                 IPI:IPI00125960.1 
                 TAS*GSS*VTSLEGTR 
                 1700 
                 Ndrg1 
                 Protein NDRG1 
                 2 
               
               
                   
               
               
                 84 
                 IPI:IPI00318938.6 
                 R{circumflex over ( )}VALGDGVQLPPGDYSTT 
                 1701 
                 Eif4ebp1 
                 Eukaryotic translation initiation 
                 2 
               
               
                   
                   
                 *PGGTLFSTT*PGGTR{circumflex over ( )} 
                   
                   
                 factor 4E-binding protein 1 
               
               
                   
               
               
                 85 
                 IPI:IPI00229571.1 
                 IS*SK@S*PGHMVILNQTK@ 
                 1702 
                 Sltm 
                 Isoform 1 of SAFB-like 
                 2 
               
               
                   
                   
                   
                   
                   
                 transcription modulator 
               
               
                   
               
               
                 86 
                 IPI:IPI00120095.2 
                 DFTK@PQDGDIIAPLIT*PLK@ 
                 1703 
                 Samhd1 
                 SAM domain and HD domain- 
                 2 
               
               
                   
                   
                   
                   
                   
                 containing protein 1 
               
               
                   
               
               
                 87 
                 IPI:IPI00340860.5 
                 T*AS*EGSEAETPEAPK 
                 1704 
                 Larp7 
                 Isoform 1 of La-related protein 7 
                 2 
               
               
                   
               
               
                 88 
                 IPI:IPI00664670.4 
                 LGS*FGSITR{circumflex over ( )} 
                 1705 
                 Flnc 
                 Isoform 1 of Filamin-C 
                 2 
               
               
                   
               
               
                 89 
                 IPI:IPI00654192.2 
                 SLS*FSEPQQPPPTVK@ 
                 1706 
                 Zfp395 
                 zinc finger protein 395 
                 2 
               
               
                   
               
               
                 90 
                 IPI:IPI00225062.2 
                 IHTTALTGQS*PPLASGHQG 
                 1707 
                 Srrm2 
                 Isoform 3 of Serine/arginine 
                 2 
               
               
                   
                   
                 EGDAPSVEPGATNIQQPSS 
                   
                   
                 repetitive matrix protein 2 
               
               
                   
                   
                 *PAPSTK 
               
               
                   
               
               
                 91 
                 IPI:IPI00225062.2 
                 IHTTALTGQS*PPLASGHQG 
                 1708 
                 Srrm2 
                 Isoform 3 of Serine/arginine 
                 2 
               
               
                   
                   
                 EGDAPSVEPGATNIQQPSS 
                   
                   
                 repetitive matrix protein 2 
               
               
                   
                   
                 *PAPS*TK@ 
               
               
                   
               
               
                 92 
                 IPI:IPI00225062.2 
                 IHTTALTGQS*PPLASGHQG 
                 1709 
                 Srrm2 
                 Isoform 3 of Serine/arginine 
                 2 
               
               
                   
                   
                 EGDAPSVEPGATNIQQPSS 
                   
                   
                 repetitive matrix protein 2 
               
               
                   
                   
                 *PAPST*K 
               
               
                   
               
               
                 93 
                 IPI:IPI00339428.9 
                 MSSHT*ETSSFLQTLTGR 
                 1710 
                 Dock7 
                 Isoform 2 of Dedicator of 
                 2 
               
               
                   
                   
                   
                   
                   
                 cytokinesis protein 7 
               
               
                   
               
               
                 94 
                 IPI:IPI00225062.2 
                 DGSGT*PSRHSLS*GS*S*P 
                 1711 
                 Srrm2 
                 Isoform 3 of Serine/arginine 
                 2 
               
               
                   
                   
                 GMKDTPQT*PSR 
                   
                   
                 repetitive matrix protein 2 
               
               
                   
               
               
                 95 
                 IPI:IPI00668709.2 
                 DRSSS*APNVHINTIEPVNID 
                 1712 
                 Braf 
                 B-Raf protein 
                 2 
               
               
                   
                   
                 DLIR 
               
               
                   
               
               
                 96 
                 IPI:IPI00135660.5 
                 RGNNS*AVGS*NADLT*IEE 
                 1713 
                 Sdpr 
                 Serum deprivation-response 
                 2 
               
               
                   
                   
                 DEEEEPVALQQAQQVR 
                   
                   
                 protein 
               
               
                   
               
               
                 97 
                 IPI:IPI00135660.5 
                 R{circumflex over ( )}GNNSAVGS*NADLT*IEE 
                 1714 
                 Sdpr 
                 Serum deprivation-response 
                 2 
               
               
                   
                   
                 DEEEEPVALQQAQQVR{circumflex over ( )} 
                   
                   
                 protein 
               
               
                   
               
               
                 98 
                 IPI:IPI00404545.2 
                 SLS*S*PTVTLSAPLEGAK@ 
                 1715 
                 Nedd4l 
                 Isoform 3 of E3 ubiquitin-protein 
                 2 
               
               
                   
                   
                   
                   
                   
                 ligase NEDD4-like 
               
               
                   
               
               
                 99 
                 IPI:IPI00121892.9 
                 R{circumflex over ( )}PPS*PDPNTK@ 
                 1716 
                 Spnb2 
                 Isoform 2 of Spectrin beta chain 
                 2 
               
               
                   
                   
                   
                   
                   
                 brain 1 
               
               
                   
               
               
                 100  
                 IPI:IPI00322707.5 
                 AKQPVIGDQNS*DSDEMLA 
                 1717 
                 Atrx 
                 Transcriptional regulator ATRX 
                 2 
               
               
                   
                   
                 VLK 
               
               
                   
               
               
                 101  
                 IPI:IPI00929786.1 
                 SLPT*TVPES*PNYR{circumflex over ( )} 
                 1718 
                 Larp1 
                 Isoform 1 of La-related protein 1 
                 3 
               
               
                   
               
               
                 102  
                 IPI:IPI00125319.1 
                 TTS*FAESCK@PVQQPSAF 
                 1719 
                 Gsk3b 
                 Glycogen synthase kinase-3 beta 
                 3 
               
               
                   
                   
                 GSMK@ 
               
               
                   
               
            
           
           
               
            
               
                 Table 9(b) 
               
            
           
           
               
               
               
               
               
            
               
                   
                 rapa median area 
                   
                   
                   
               
               
                 ID 
                 ratio 
                 rapa median SN ratio 
                 KU median area ratio 
                 KU median SN ratio 
               
               
                   
               
               
                  1 
                 −1.15E+00 
                 −1.14E+00 
                 −0.8183 
                 −0.9318 
               
               
                   
               
               
                  2 
                 −2.1437 
                 −2.4238 
                 −0.78695 
                 −0.9492 
               
               
                   
               
               
                  3 
                 −4.758 
                 −4.9643 
                 −0.6283 
                 −0.5475 
               
               
                   
               
               
                  4 
                 −4.62805 
                 −4.47925 
                 −0.6283 
                 −0.5475 
               
               
                   
               
               
                  5 
                 −3.6217 
                 −3.885 
                 −0.6283 
                 −0.5475 
               
               
                   
               
               
                  6 
                 −1.0246 
                 −1.0724 
                 −0.5666 
                 0.1321 
               
               
                   
               
               
                  7 
                 −1.881 
                 −1.90875 
                 −0.5354 
                 −0.5361 
               
               
                   
               
               
                  8 
                 −5.2234 
                 −5.13485 
                 −0.4254 
                 −0.6826 
               
               
                   
               
               
                  9 
                 −1.8021 
                 −2.01515 
                 −0.4151 
                 −0.4336 
               
               
                   
               
               
                 10 
                 −1.5621 
                 −1.0464 
                 −0.3725 
                 −0.7405 
               
               
                   
               
               
                 11 
                 −1.4347 
                 −1.3061 
                 −0.3725 
                 −0.7405 
               
               
                   
               
               
                 12 
                 −1.6324 
                 −1.5779 
                 −0.3224 
                 −0.0637 
               
               
                   
               
               
                 13 
                 −1.5511 
                 −1.71335 
                 −0.2831 
                 −0.0584 
               
               
                   
               
               
                 14 
                 −1.78365 
                 −2.00075 
                 −0.2767 
                 0.0092 
               
               
                   
               
               
                 15 
                 −1.7555 
                 −2.0749 
                 −0.2767 
                 0.0092 
               
               
                   
               
               
                 16 
                 −1.7499 
                 −1.7737 
                 −0.2767 
                 0.0092 
               
               
                   
               
               
                 17 
                 −1.5242 
                 −1.76425 
                 −0.2767 
                 0.0092 
               
               
                   
               
               
                 18 
                 −2.0759 
                 −2.2586 
                 −0.2661 
                 −0.1505 
               
               
                   
               
               
                 19 
                 −1.9707 
                 −1.7471 
                 −0.2661 
                 −0.1505 
               
               
                   
               
               
                 20 
                 −1.8874 
                 −1.85315 
                 −0.2661 
                 −0.1505 
               
               
                   
               
               
                 21 
                 −1.8106 
                 −1.691 
                 −0.2661 
                 −0.1505 
               
               
                   
               
               
                 22 
                 −1.6838 
                 −1.5207 
                 −0.2661 
                 −0.1505 
               
               
                   
               
               
                 23 
                 −2.8898 
                 −2.7784 
                 −0.2201 
                 −0.1513 
               
               
                   
               
               
                 24 
                 −1.0015 
                 −0.8287 
                 −0.2135 
                 −0.3206 
               
               
                   
               
               
                 25 
                 −3.15205 
                 −2.9693 
                 −0.213 
                 0.1493 
               
               
                   
               
               
                 26 
                 −1.3868 
                 −0.6688 
                 −0.1992 
                 −0.1577 
               
               
                   
               
               
                 27 
                 −1.1818 
                 −1.15455 
                 −0.1474 
                 −0.0308 
               
               
                   
               
               
                 28 
                 −1.7403 
                 −1.8968 
                 −0.1417 
                 0.6197 
               
               
                   
               
               
                 29 
                 −1.6267 
                 −1.0033 
                 −0.139 
                 −0.2714 
               
               
                   
               
               
                 30 
                 −1.0844 
                 −1.1514 
                 −0.106 
                 −0.2609 
               
               
                   
               
               
                 31 
                 −2.78805 
                 −1.56635 
                 −0.1017 
                 −0.8833 
               
               
                   
               
               
                 32 
                 −3.0877 
                 −2.2749 
                 −0.099 
                 0.6127 
               
               
                   
               
               
                 33 
                 −2.20425 
                 −2.1077 
                 −0.085 
                 0.023 
               
               
                   
               
               
                 34 
                 −1.2842 
                 −0.6546 
                 −0.0822 
                 0.1059 
               
               
                   
               
               
                 35 
                 −1.7868 
                 −2.1396 
                 −0.0816 
                 0.1618 
               
               
                   
               
               
                 36 
                 −1.2551 
                 −1.22675 
                 −0.0656 
                 −0.106 
               
               
                   
               
               
                 37 
                 −2.9525 
                 −3.6913 
                 −0.0637 
                 0.7614 
               
               
                   
               
               
                 38 
                 −1.1888 
                 −1.2446 
                 −0.014 
                 −0.0308 
               
               
                   
               
               
                 39 
                 −1.2382 
                 −1.25285 
                 −0.0136 
                 0.0107 
               
               
                   
               
               
                 40 
                 −2.1557 
                 −2.1257 
                 −0.01 
                 −0.0601 
               
               
                   
               
               
                 41 
                 −4.4981 
                 −3.9942 
                 0.0259 
                 −0.0762 
               
               
                   
               
               
                 42 
                 −1.7508 
                 −0.9897 
                 0.0386 
                 0.3631 
               
               
                   
               
               
                 43 
                 −1.896 
                 −2.1685 
                 0.0563 
                 0.2174 
               
               
                   
               
               
                 44 
                 −1.89265 
                 −2.1434 
                 0.0563 
                 0.1073 
               
               
                   
               
               
                 45 
                 −1.40465 
                 −1.02655 
                 0.0563 
                 0.2174 
               
               
                   
               
               
                 46 
                 −1.896 
                 −2.1685 
                 0.0814 
                 0.17005 
               
               
                   
               
               
                 47 
                 −3.6492 
                 −3.6492 
                 0.0966 
                 0.0223 
               
               
                   
               
               
                 48 
                 −1.8973 
                 −2.1434 
                 0.1063 
                 0.2306 
               
               
                   
               
               
                 49 
                 −1.273 
                 −0.7556 
                 0.1063 
                 0.2306 
               
               
                   
               
               
                 50 
                 −2.8428 
                 −2.9973 
                 0.1159 
                 0.0362 
               
               
                   
               
               
                 51 
                 −2.8019 
                 −2.9973 
                 0.1159 
                 0.0362 
               
               
                   
               
               
                 52 
                 −1.2352 
                 −0.0592 
                 0.1368 
                 0.1632 
               
               
                   
               
               
                 53 
                 −3.106 
                 −3.2482 
                 0.1555 
                 0.3337 
               
               
                   
               
               
                 54 
                 −2.9525 
                 −3.6913 
                 0.1555 
                 0.3337 
               
               
                   
               
               
                 55 
                 −1.298 
                 −1.4299 
                 0.2219 
                 0.413 
               
               
                   
               
               
                 56 
                 −1.7403 
                 −1.8968 
                 0.22985 
                 0.1085 
               
               
                   
               
               
                 57 
                 −1.3906 
                 −1.2466 
                 0.2704 
                 1.5615 
               
               
                   
               
               
                 58 
                 −1.1401 
                 −1.2853 
                 0.2835 
                 0.1358 
               
               
                   
               
               
                 59 
                 −2.4187 
                 −0.9488 
                 0.307 
                 0.366 
               
               
                   
               
               
                 60 
                 −1.3056 
                 −1.2452 
                 0.3118 
                 0.4053 
               
               
                   
               
               
                 61 
                 −1.2719 
                 −1.0234 
                 0.3118 
                 0.4053 
               
               
                   
               
               
                 62 
                 −1.4486 
                 −1.5455 
                 0.3219 
                 0.2377 
               
               
                   
               
               
                 63 
                 −3.8536 
                 −3.8536 
                 0.3485 
                 0.0243 
               
               
                   
               
               
                 64 
                 −1.36155 
                 −1.26665 
                 0.3516 
                 0.4392 
               
               
                   
               
               
                 65 
                 −1.889 
                 −1.727 
                 0.3696 
                 1.0368 
               
               
                   
               
               
                 66 
                 −2.0572 
                 −2.2717 
                 0.3908 
                 0.1481 
               
               
                   
               
               
                 67 
                 −1.626 
                 −2.0445 
                 0.51825 
                 0.767 
               
               
                   
               
               
                 68 
                 −1.29335 
                 −1.2722 
                 0.51825 
                 0.767 
               
               
                   
               
               
                 69 
                 −1.9492 
                 −2.05475 
                 0.5526 
                 0.865 
               
               
                   
               
               
                 70 
                 −1.1567 
                 −1.0106 
                 0.5969 
                 0.9976 
               
               
                   
               
               
                 71 
                 −1.1567 
                 −1.0106 
                 0.5969 
                 0.9976 
               
               
                   
               
               
                 72 
                 −2.818 
                 −2.9973 
                 1.1365 
                 1.0801 
               
               
                   
               
               
                 73 
                 −3.4866 
                 −3.4138 
                 1.2714 
                 1.4529 
               
               
                   
               
               
                 74 
                 0.0401 
                 −0.1138 
                 −3.4595 
                 −5.0415 
               
               
                   
               
               
                 75 
                 0.011 
                 −0.1502 
                 −3.3715 
                 −3.3715 
               
               
                   
               
               
                 76 
                 −0.22145 
                 −0.31255 
                 −2.9948 
                 −2.3042 
               
               
                   
               
               
                 77 
                 0.2389 
                 0.2797 
                 −2.8989 
                 −2.0993 
               
               
                   
               
               
                 78 
                 −0.2639 
                 −0.32955 
                 −2.8403 
                 −2.8893 
               
               
                   
               
               
                 79 
                 −0.2514 
                 −0.2836 
                 −2.7755 
                 −2.167 
               
               
                   
               
               
                 80 
                 −0.2469 
                 −0.3415 
                 −2.5654 
                 −2.1344 
               
               
                   
               
               
                 81 
                 −0.58015 
                 −0.1451 
                 −2.5295 
                 −2.6811 
               
               
                   
               
               
                 82 
                 −0.1752 
                 0.3008 
                 −2.3289 
                 −2.6763 
               
               
                   
               
               
                 83 
                 0.2073 
                 0.2067 
                 −2.0546 
                 −2.0769 
               
               
                   
               
               
                 84 
                 −0.3079 
                 −0.4553 
                 −1.759 
                 −1.6004 
               
               
                   
               
               
                 85 
                 0.13985 
                 0.04745 
                 −1.5237 
                 −1.538 
               
               
                   
               
               
                 86 
                 −0.1736 
                 −0.41725 
                 −1.3706 
                 −0.9742 
               
               
                   
               
               
                 87 
                 −0.1646 
                 −0.2464 
                 −1.3468 
                 −1.5444 
               
               
                   
               
               
                 88 
                 0.3745 
                 0.3233 
                 −1.2893 
                 −1.2512 
               
               
                   
               
               
                 89 
                 −0.5295 
                 −0.8185 
                 −1.1648 
                 −1.0131 
               
               
                   
               
               
                 90 
                 −0.4199 
                 −0.3301 
                 −1.1227 
                 −0.4758 
               
               
                   
               
               
                 91 
                 −0.2531 
                 −0.1626 
                 −1.1227 
                 −0.4758 
               
               
                   
               
               
                 92 
                 −0.1997 
                 −0.1626 
                 −1.1227 
                 −0.4758 
               
               
                   
               
               
                 93 
                 0.1923 
                 0.3451 
                 −1.1197 
                 −1.2356 
               
               
                   
               
               
                 94 
                 −0.0084 
                 0.0364 
                 −1.0814 
                 −1.582 
               
               
                   
               
               
                 95 
                 −0.3065 
                 −0.4384 
                 −1.0477 
                 −1.431 
               
               
                   
               
               
                 96 
                 −0.18955 
                 −0.4136 
                 −1.0458 
                 −1.0184 
               
               
                   
               
               
                 97 
                 −0.15495 
                 −0.3246 
                 −1.0458 
                 −1.0184 
               
               
                   
               
               
                 98 
                 −0.573 
                 −0.2978 
                 −1.0265 
                 −0.7599 
               
               
                   
               
               
                 99 
                 0.0109 
                 −0.0378 
                 −1.0209 
                 −0.674 
               
               
                   
               
               
                 100  
                 0.10215 
                 0.0699 
                 −1.011 
                 −2.1889 
               
               
                   
               
               
                 101  
                 −2.1207 
                 −2.1939 
                 −6.1589 
                 −5.4183 
               
               
                   
               
               
                 102  
                 −1.71915 
                 −1.62995 
                 −1.07715 
                 −2.06845 
               
               
                   
               
               
                 Table 9. Classification of mTOR targets identified in the Rapamycin and Ku-0063794 screens. Class 1 represents downstream effectors of rapamycin-sensitive mTORC1. Class 2 represents downstream effectors of rapamycin-insensitive mTORC1 or mTORC2. Class 3 represents the proteins downstream of both mTORC1 and mTORC2. Name of the genes and the sequences of the phosphopeptides are shown. Table 9 is provided in two parts because the colums span more than a single page. Table 9(a) contains colums 1-6 of Table 9 and Table 9(b) contains columns 7-10, wherein corresponding entries are identified in an ID column in each section. Information provided in (a) for ID 1 relates to the information provided in (b) for ID 1 and vice versa, information provided in (a) for ID 2 relates to the information provided in (b) for ID 2 and vice versa, and so on. 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 10 
               
               
                   
               
               
                 Gene ontology analysis of the hits identified in the rapamycin and Ku-0063794 screens. The Table contains 
               
               
                 four subsections: Biological processes that the rapamycin-sensitive and Ku-0063794-sensitive hits overrepresented 
               
               
                 are identified in the “Rapa BP GO” and “Ku BP GO” subsection, respectively. Pathways that the Rapamycin- 
               
               
                 senstitive and Ku-0063794-sensitive hits overrepresented are shown under “Rapa KEGG pathways” and “Ku 
               
               
                 KEGG pathways,” respectively. Subsections are displayed in three parts, (a), (b), and (c), because the Table 
               
               
                 columns span more than one page. Corresponding entries are identified by an ID number. For example, entries 
               
               
                 under ID number 1 in Rapa BP GO (a), (b), and (c) refer to the same entry, entries under ID number 2 in Rapa BP 
               
               
                 GO (a), (b), and (c) refer to the same entry, entries under ID number 1 in Rapa KEGG pathways (a), (b), and (c) 
               
               
                 refer to the same entry, and so forth. 
               
               
                   
               
             
            
               
                 Rapa BP GO pathways (a): 
               
            
           
           
               
               
               
               
               
            
               
                 ID 
                 Term 
                 Count 
                 % 
                 PValue 
               
               
                   
               
               
                 1 
                 GO:0010605~negative regulation of macromolecule 
                 20 
                 10.41666667 
                 4.18E−07 
               
               
                   
                 metabolic process 
                   
                   
                   
               
               
                 2 
                 GO:0031327~negative regulation of cellular  
                 17 
                  8.854166667 
                 4.17E−06 
               
               
                   
                 biosynthetic process 
                   
                   
                   
               
               
                 3 
                 GO:0010558~negative regulation of macromolecule 
                 16 
                  8.333333333 
                 1.31E−05 
               
               
                   
                 biosynthetic process 
                   
                   
                   
               
               
                 4 
                 GO:0045934~negative regulation of nucleobase, 
                 15 
                  7.8125 
                 0.0000314 
               
               
                   
                 nucleoside, nucleotide and nucleic acid metabolic  
                   
                   
                   
               
               
                   
                 process 
                   
                   
                   
               
               
                 5 
                 GO:0032868~response to insulin stimulus 
                 6 
                  3.125 
                 0.000264 
               
               
                 6 
                 GO:0016481~negative regulation of transcription 
                 13 
                  6.770833333 
                 0.000271 
               
               
                 7 
                 GO:0016192~vesicle-mediated transport 
                 14 
                  7.291666667 
                 0.000603 
               
               
                 8 
                 GO:0032869~cellular response to insulin stimulus 
                 5 
                  2.604166667 
                 0.000783 
               
               
                 9 
                 GO:0051253~negative regulation of RNA  
                 11 
                  5.729166667 
                 0.000886 
               
               
                   
                 metabolic process 
                   
                   
                   
               
               
                 10 
                 GO:0051248~negative regulation of protein  
                 6 
                  3.125 
                 0.00096 
               
               
                   
                 metabolic process 
                   
                   
                   
               
               
                 11 
                 GO:0006898~receptor-mediated endocytosis 
                 4 
                  2.083333333 
                 0.001048574 
               
               
                 12 
                 GO:0006468~protein amino acid phosphorylation 
                 16 
                  8.333333333 
                 0.00137311 
               
               
                 13 
                 GO:0051276~chromosome organization 
                 12 
                  6.25 
                 0.001936745 
               
               
                 14 
                 GO:0016568~chromatin modification 
                 9 
                  4.6875 
                 0.002136023 
               
               
                 15 
                 GO:0043434~response to peptide hormone stimulus 
                 6 
                  3.125 
                 0.002310739 
               
               
                 16 
                 GO:0032870~cellular response to hormone stimulus 
                 5 
                  2.604166667 
                 0.002406516 
               
               
                 17 
                 GO:0008286~insulin receptor signaling pathway 
                 4 
                  2.083333333 
                 0.002457872 
               
               
                 18 
                 GO:0045892~negative regulation of transcription,  
                 10 
                  5.208333333 
                 0.003123471 
               
               
                   
                 DNA dependent 
                   
                   
                   
               
               
                 19 
                 GO:0006325~chromatin organization 
                 10 
                  5.208333333 
                 0.003622675 
               
               
                 20 
                 GO:0046777~protein amino acid autophosphory- 
                 5 
                  2.604166667 
                 0.003851564 
               
               
                   
                 lation 
                   
                   
                   
               
               
                 21 
                 GO:0010627~regulation of protein kinase cascade 
                 7 
                  3.645833333 
                 0.004027038 
               
               
                 22 
                 GO:0016310~phosphorylation 
                 16 
                  8.333333333 
                 0.004128421 
               
               
                 23 
                 GO:0051656~establishment of organelle localization 
                 4 
                  2.083333333 
                 0.004303328 
               
               
                 24 
                 GO:0007010~cytoskeleton organization 
                 10 
                  5.208333333 
                 0.004531801 
               
               
                 25 
                 GO:0032535~regulation of cellular component size 
                 7 
                  3.645833333 
                 0.004843432 
               
               
                 26 
                 GO:0022402~cell cycle process 
                 11 
                  5.729166667 
                 0.00498568 
               
               
                 27 
                 GO:0045926~negative regulation of growth 
                 5 
                  2.604166667 
                 0.005003024 
               
               
                 28 
                 GO:0032269~negative regulation of cellular protein 
                 5 
                  2.604166667 
                 0.005258125 
               
               
                   
                 metabolic process 
                   
                   
                   
               
               
                 29 
                 GO:0065003~macromolecular complex assembly 
                 10 
                  5.208333333 
                 0.005717288 
               
               
                 30 
                 GO:0032268~regulation of cellular protein metabolic 
                 9 
                  4.6875 
                 0.006003754 
               
               
                   
                 process 
                   
                   
                   
               
               
                 31 
                 GO:0000122~negative regulation of transcription  
                 8 
                  4.166666667 
                 0.007342706 
               
               
                   
                 from RNA polymerase II promoter 
                   
                   
                   
               
               
                 32 
                 GO:0032319~regulation of Rho GTPase activity 
                 3 
                  1.5625 
                 0.007895767 
               
               
                 33 
                 GO:0046578~regulation of Ras protein signal 
                 7 
                  3.645833333 
                 0.008452332 
               
               
                   
                 transduction 
                   
                   
                   
               
               
                 34 
                 GO:0043933~macromolecular complex subunit 
                 10 
                  5.208333333 
                 0.009572997 
               
               
                   
                 organization 
                   
                   
                   
               
               
                 35 
                 GO:0006793~phosphorus metabolic process 
                 17 
                  8.854166667 
                 0.009756342 
               
               
                 36 
                 GO:0006796~phosphate metabolic process 
                 17 
                  8.854166667 
                 0.009756342 
               
               
                 37 
                 GO:0006897~endocytosis 
                 7 
                  3.645833333 
                 0.010081394 
               
               
                 38 
                 GO:0010324~membrane invagination 
                 7 
                  3.645833333 
                 0.010081394 
               
               
                 39 
                 GO:0006396~RNA processing 
                 11 
                  5.729166667 
                 0.01020022 
               
               
                 40 
                 GO:0007169~transmembrane receptor protein  
                 7 
                  3.645833333 
                 0.01110676 
               
               
                   
                 tyrosine kinase signaling pathway 
                   
                   
                   
               
               
                 41 
                 GO:0010608~posttranscriptional regulation of gene 
                 6 
                  3.125 
                 0.01469374 
               
               
                   
                 expression 
                   
                   
                   
               
               
                 42 
                 GO:0045792~negative regulation of cell size 
                 4 
                  2.083333333 
                 0.014742447 
               
               
                 43 
                 GO:0001701~in utero embryonic development 
                 8 
                  4.166666667 
                 0.015417559 
               
               
                 44 
                 GO:0051640~organelle localization 
                 4 
                  2.083333333 
                 0.015500935 
               
               
                 45 
                 GO:0051493~regulation of cytoskeleton organization 
                 5 
                  2.604166667 
                 0.015757695 
               
               
                 46 
                 GO:0007049~cell cycle 
                 13 
                  6.770833333 
                 0.015795779 
               
               
                 47 
                 GO:0006417~regulation of translation 
                 5 
                  2.604166667 
                 0.016293879 
               
               
                 48 
                 GO:0017148~negative regulation of translation 
                 3 
                  1.5625 
                 0.019054263 
               
               
                 49 
                 GO:0034622~cellular macromolecular complex  
                 7 
                  3.645833333 
                 0.019238583 
               
               
                   
                 assembly 
                   
                   
                   
               
               
                 50 
                 GO:0008361~regulation of cell size 
                 5 
                  2.604166667 
                 0.020996944 
               
               
                 51 
                 GO:0009725~response to hormone stimulus 
                 6 
                  3.125 
                 0.022401918 
               
               
                 52 
                 GO:0051056~regulation of small GTPase mediated  
                 7 
                  3.645833333 
                 0.023850905 
               
               
                   
                 signal transduction 
                   
                   
                   
               
               
                 53 
                 GO:0030029~actin filament-based process 
                 6 
                  3.125 
                 0.028573614 
               
               
                 54 
                 GO:0048729~tissue morphogenesis 
                 7 
                  3.645833333 
                 0.028642761 
               
               
                 55 
                 GO:0001932~regulation of protein amino acid 
                 5 
                  2.604166667 
                 0.030261806 
               
               
                   
                 phosphorylation 
                   
                   
                   
               
               
                 56 
                 GO:0008104~protein localization 
                 14 
                  7.291666667 
                 0.031319732 
               
               
                 57 
                 GO:0000278~mitotic cell cycle 
                 7 
                  3.645833333 
                 0.031803074 
               
               
                 58 
                 GO:0034621~cellular macromolecular complex  
                 7 
                  3.645833333 
                 0.032351058 
               
               
                   
                 subunit organization 
                   
                   
                   
               
               
                 59 
                 GO:0009719~response to endogenous stimulus 
                 6 
                  3.125 
                 0.03367924 
               
               
                 60 
                 GO:0045449~regulation of transcription 
                 31 
                 16.14583333 
                 0.03551581 
               
               
                 61 
                 GO:0007163~establishment or maintenance of cell 
                 3 
                  1.5625 
                 0.036247509 
               
               
                   
                 polarity 
                   
                   
                   
               
               
                 62 
                 GO:0080135~regulation of cellular response to stress 
                 4 
                  2.083333333 
                 0.036466875 
               
               
                 63 
                 GO:0006357~regulation of transcription from RNA 
                 12 
                  6.25 
                 0.037453702 
               
               
                   
                 polymerase II promoter 
                   
                   
                   
               
               
                 64 
                 GO:0032314~regulation of Rac GTPase activity 
                 2 
                  1.041666667 
                 0.038299417 
               
               
                 65 
                 GO:0040007~growth 
                 6 
                  3.125 
                 0.040063168 
               
               
                 66 
                 GO:0022403~cell cycle phase 
                 8 
                  4.166666667 
                 0.040932988 
               
               
                 67 
                 GO:0031328-positive regulation of cellular  
                 11 
                  5.729166667 
                 0.042602185 
               
               
                   
                 biosynthetic process 
                   
                   
                   
               
               
                 68 
                 GO:0032318~regulation of Ras GTPase activity 
                 4 
                  2.083333333 
                 0.042864282 
               
               
                 69 
                 GO:0010604~positive regulation of macromolecule 
                 12 
                  6.25 
                 0.044146336 
               
               
                   
                 metabolic process 
                   
                   
                   
               
               
                 70 
                 GO:0022613~ribonucleoprotein complex biogenesis 
                 5 
                  2.604166667 
                 0.044519805 
               
               
                 71 
                 GO:0009891~positive regulation of biosynthetic  
                 11 
                  5.729166667 
                 0.044819532 
               
               
                   
                 process 
                   
                   
                   
               
               
                 72 
                 GO:0046822~regulation of nucleocytoplasmic  
                 3 
                  1.5625 
                 0.045236118 
               
               
                   
                 transport 
                   
                   
                   
               
               
                 73 
                 GO:0006346~methylation-dependent chromatin  
                 2 
                  1.041666667 
                 0.047644564 
               
               
                   
                 silencing 
                   
                   
                   
               
               
                 74 
                 GO:0016044~membrane organization 
                 7 
                  3.645833333 
                 0.049524346 
               
               
                 75 
                 GO:0007167~enzyme linked receptor protein  
                 7 
                  3.645833333 
                 0.05025049 
               
               
                   
                 signaling pathway 
                   
                   
                   
               
               
                 76 
                 GO:0035023~regulation of Rho protein signal 
                 4 
                  2.083333333 
                 0.051230918 
               
               
                   
                 transduction 
                   
                   
                   
               
               
                 77 
                 GO:0043009~chordate embryonic development 
                 9 
                  4.6875 
                 0.052874272 
               
               
                 78 
                 GO:0006916~anti-apoptosis 
                 4 
                  2.083333333 
                 0.054183284 
               
               
                 79 
                 GO:0009792~embryonic development ending in  
                 9 
                  4.6875 
                 0.055294577 
               
               
                   
                 birth or egg hatching 
                   
                   
                   
               
               
                 80 
                 GO:0044087~regulation of cellular component  
                 4 
                  2.083333333 
                 0.055689578 
               
               
                   
                 biogenesis 
                   
                   
                   
               
               
                 81 
                 GO:0006350~transcription 
                 25 
                 13.02083333 
                 0.055970599 
               
               
                 82 
                 GO:0043062~extracellular structure organization 
                 5 
                  2.604166667 
                 0.057303217 
               
               
                 83 
                 GO:0043122~regulation of I-kappaB kinase/ 
                 3 
                  1.5625 
                 0.057483236 
               
               
                   
                 NF-kappaB cascade 
                   
                   
                   
               
               
                 84 
                 GO:0051726~regulation of cell cycle 
                 6 
                  3.125 
                 0.057658627 
               
               
                 85 
                 GO:0046907~intracellular transport 
                 9 
                  4.6875 
                 0.059056688 
               
               
                 86 
                 GO:0006260~DNA replication 
                 5 
                  2.604166667 
                 0.060776557 
               
               
                 87 
                 GO:0048598~embryonic morphogenesis 
                 8 
                  4.166666667 
                 0.060833555 
               
               
                 88 
                 GO:0043087~regulation of GTPase activity 
                 4 
                  2.083333333 
                 0.061912428 
               
               
                 89 
                 GO:0051129~negative regulation of cellular  
                 4 
                  2.083333333 
                 0.061912428 
               
               
                   
                 component organization 
                   
                   
                   
               
               
                 90 
                 GO:0032386~regulation of intracellular transport 
                 3 
                  1.5625 
                 0.062669535 
               
               
                 91 
                 GO:0033043~regulation of organelle organization 
                 5 
                  2.604166667 
                 0.063153096 
               
               
                 92 
                 GO:0042325~regulation of phosphorylation 
                 7 
                  3.645833333 
                 0.063602017 
               
               
                 93 
                 GO:0045786~negative regulation of cell cycle 
                 3 
                  1.5625 
                 0.065320236 
               
               
                 94 
                 GO:0001570~vasculogenesis 
                 3 
                  1.5625 
                 0.065320236 
               
               
                 95 
                 GO:0045947~negative regulation of translational  
                 2 
                  1.041666667 
                 0.066065335 
               
               
                   
                 initiation 
                   
                   
                   
               
               
                 96 
                 GO:0006461~protein complex assembly 
                 6 
                  3.125 
                 0.070461851 
               
               
                 97 
                 GO:0070271~protein complex biogenesis 
                 6 
                  3.125 
                 0.070461851 
               
               
                 98 
                 GO:0030833~regulation of actin filament  
                 3 
                  1.5625 
                 0.070731878 
               
               
                   
                 polymerization 
                   
                   
                   
               
               
                 99 
                 GO:0010557~positive regulation of macromolecule 
                 10 
                  5.208333333 
                 0.073220823 
               
               
                   
                 biosynthetic process 
                   
                   
                   
               
               
                 100 
                 GO:0019220~regulation of phosphate metabolic  
                 7 
                  3.645833333 
                 0.073259901 
               
               
                   
                 process 
                   
                   
                   
               
               
                 101 
                 GO:0051174~regulation of phosphorus metabolic  
                 7 
                  3.645833333 
                 0.073259901 
               
               
                   
                 process 
                   
                   
                   
               
               
                 102 
                 GO:0048589~developmental growth 
                 4 
                  2.083333333 
                 0.073541659 
               
               
                 103 
                 GO:0030838~positive regulation of actin filament 
                 2 
                  1.041666667 
                 0.075142677 
               
               
                   
                 polymerization 
                   
                   
                   
               
               
                 104 
                 GO:0030308~negative regulation of cell growth 
                 3 
                  1.5625 
                 0.076284196 
               
               
                 105 
                 GO:0030036~actin cytoskeleton organization 
                 5 
                  2.604166667 
                 0.077082848 
               
               
                 106 
                 GO:0031399~regulation of protein modification  
                 5 
                  2.604166667 
                 0.077082848 
               
               
                   
                 process 
                   
                   
                   
               
               
                 107 
                 GO:0000902~cell morphogenesis 
                 7 
                  3.645833333 
                 0.080785789 
               
               
                 108 
                 GO:0016477~cell migration 
                 6 
                  3.125 
                 0.08471051 
               
               
                 109 
                 GO:0008064~regulation of actin polymerization or 
                 3 
                  1.5625 
                 0.084860387 
               
               
                   
                 depolymerization 
                   
                   
                   
               
               
                 110 
                 GO:0030832~regulation of actin filament length 
                 3 
                  1.5625 
                 0.08778162 
               
               
                 111 
                 GO:0002009~morphogenesis of an epithelium 
                 5 
                  2.604166667 
                 0.088103636 
               
               
                 112 
                 GO:0006333~chromatin assembly or disassembly 
                 4 
                  2.083333333 
                 0.089801855 
               
               
                 113 
                 GO:0010638~positive regulation of organelle  
                 3 
                  1.5625 
                 0.090732662 
               
               
                   
                 organization 
                   
                   
                   
               
               
                 114 
                 GO:0045941~positive regulation of transcription 
                 9 
                  4.6875 
                 0.091555467 
               
               
                 115 
                 GO:0006887~exocytosis 
                 4 
                  2.083333333 
                 0.091694717 
               
               
                 116 
                 GO:0008283~cell proliferation 
                 6 
                  3.125 
                 0.092969193 
               
               
                 117 
                 GO:0035020~regulation of Rac protein signal 
                 2 
                  1.041666667 
                 0.093035503 
               
               
                   
                 transduction 
                   
                   
                   
               
               
                 118 
                 GO:0000226~microtubule cytoskeleton organization 
                 4 
                  2.083333333 
                 0.093604179 
               
               
                 119 
                 GO:0060562~epithelial tube morphogenesis 
                 4 
                  2.083333333 
                 0.093604179 
               
               
                   
               
            
           
           
               
            
               
                 Rapa BP GO pathways (b): 
               
            
           
           
               
               
            
               
                 ID 
                 Genes 
               
               
                   
               
               
                  1 
                 BCLAF1,FOXK1,GM5611,ZEB2,SAP30,EIP4EBP1,SORBS3,EIF4EBP2,GM7289,FAM129A,HELLS, 
               
               
                   
                 IBTK,LOC100046628,NACC1,GM9118,TRIM28,RB1,EHMT2,FLNA,FXR1,GM6477,NFIC,CUX1,LOC 
               
               
                   
                 633387,SMARCA4 
               
               
                  2 
                 PALM,BCLAF1,NACC1,FOXK1,TRIM28,ZEB2,RB1,EHMT2,FXR1,SAP30,EIF4EBP1,SORBS3, 
               
               
                   
                 EIF4EBP2,CUX1,NFIC,HELLS,SMARCA4 
               
               
                  3 
                 BCLAF1,NACC1,FOXK1,TRIM28,ZEB2,RB1,EHMT2,FXR1,SAP30,EIF4EBP2,SORBS3,EIF4EBP2, 
               
               
                   
                 CUX1,NFIC,HELLS,SMARCA4 
               
               
                  4 
                 PALM,LOC100046628,BCLAF1,NACC1,FOXK1,GM9118,TRIM28,GM5611,ZEB2,RB1,EHMT2, 
               
               
                   
                 GM6477,SAP30,SORBS3,NPM1,GM7289,CUX1,NFIC,LOC633387,HELLS,SMARCA4 
               
               
                  5 
                 ZFP106,IRS2,EIF4EBP1,EIF4EBP2,LOC100048123,LOC544757,MTOR,AKT2 
               
               
                  6 
                 NACC1,BCLAF1,FOXK1,TRIM28,ZEB2,RB1,EHMT2,SAP30,SORBS3,NFIC,CUX1,HELLS,SMARCA4 
               
               
                  7 
                 MYO5A,GM8786,LOC100048600,SNX17,ARHGAP17,LLGL1,SCRIB,FLNA,DAB2,CTTN,ULK1,RAB1, 
               
               
                   
                 FKBP15,CUX1,ERC1,TRIP10 
               
               
                  8 
                 ZFP106,IRS2,EIF4EBP1,EIF4DBP2,LOC100048123,LOC544757,AKT2 
               
               
                  9 
                 LOC100046628,FOXK1,GM9118,TRIM28,GM5611,RB1,EHMT2,GM6477,SAP30,SORBS3,NPM1,GM7 
               
               
                   
                 289,CUX1,NFIC,LOC633387,HELLS,SMARCA4 
               
               
                  10 
                 IBTK,EIF4EBP1,EIF4EBP2,FAM129A,FLNA,FXR1 
               
               
                  11 
                 DAB2,CTTN,GM8786,ULK1,SNX17 
               
               
                  12 
                 SRPK2,GM4521,BCR,TRIM28,LOC544757,PKN2,WNK1,RPS6KB1,PRKD2,PTK2,LOC100048123,ULK 
               
               
                   
                 1,AAK1,GSK3B,EEF2K,BMP2K,CDK12,MTOR,AKT2 
               
               
                  13 
                 KDM6A,PDS5B,ARID1A,RB1,EHMT2,1600027N09RIK,SMARCC2,LOC675933,CHD1,KDM3B,TINF2, 
               
               
                   
                 HELLS,SMARCA4 
               
               
                  14 
                 KDM6A,SMARCC2,CHD1,KDM3B,RB1,1600027N09RIK,EHMT2,HELLS,SMARCA4 
               
               
                  15 
                 ZFP106,IRS2,EIF4EBP1,EIF4EBP2,LOC100048123,LOC544757,MTOR,AKT2 
               
               
                  16 
                 ZFP106,IRS2,EIF4EBP1,EIF4EBP2,LOC100048123,LOC544757,AKT2 
               
               
                  17 
                 ZFP106,IRS2,EIF4EBP1,EIF4EBP2 
               
               
                  18 
                 SAP30,SORBS3,FOXK1,TRIM28,RB1,CUX1,EHMT2,NFIC,HELLS,SMARCA4 
               
               
                  19 
                 KDM6A,SMARCC2,LOC675933,CHD1,ARID1A,KDM3B,RB1,1600027N09RIK,EHMT2,HELLS, 
               
               
                   
                 SMARCA4 
               
               
                  20 
                 PTK2,ULK1,TRIM28,CDK12,MTOR 
               
               
                  21 
                 PDCD11,SORBS3,LOC100048123,SQSTM1,LOC544757,ZEB2,RICTOR,FLNA,AKT2 
               
               
                  22 
                 SRPK2,GM4521,BCR,TRIM28,LOC544757,PKN2,WNK1,RPS6KB1,PRKD2,LOC100048123,ULK1, 
               
               
                   
                 AAK1,GSK3B,EEF2K,BMP2K,CDK12,MTOR,AKT2 
               
               
                  23 
                 MYO5A,LOC100046628,PTK2,GM9118,NPM1,GM5611,GM7289,SCRIB,LOC633387,GM6477 
               
               
                  24 
                 INF2,PALM,LOC100046628,FMNL3,GM9118,GM5611,ARHGAP17,RICTOR,INF2Q,FLNA,GM6477, 
               
               
                   
                 PTK2,NPM1,MTAP1B,GM7289,LOC633387,RANBP10 
               
               
                  25 
                 LOC100046628,GM9118,FOXK1,GM5611,RICTOR,GM6477,ULK1,NPM1,GM7289,SPNA2,MTOR, 
               
               
                   
                 DNAJC2,LOC633387 
               
               
                  26 
                 LOC100046628,PDS5B,ZC3HC1,GM9118,AHCTF1,GM5611,RB1,EHMT2,CD2AP,GM6477,MACF1, 
               
               
                   
                 GSK3B,NPM1,GM7289,DNAJC2,LOC633387,HELLS 
               
               
                  27 
                 ATXN2,PTK2,FOXK1,ULK1,DNAJC2 
               
               
                  28 
                 IBTK,EIF4EBP1,EIF4EBP2,FAM129A,FXR1 
               
               
                  29 
                 SRPK2,LOC100046628,NACC1,GM9118,AHCTF1,GM5611,FLNA,GM6477,EIF3A,PTK2,GTF2F1, 
               
               
                   
                 NPM1,GM7289,LOC633387,HELLS,SMARCA4 
               
               
                  30 
                 IBTK,EIF4G1,EIF4EBP1,EIF4EBP2,ZEB2,MTOR,RICTOR,FAM129A,FXR1 
               
               
                  31 
                 SAP30,SORBS3,TRIM28,RB1,CUX1,EHMT2,NFIC,SMARCA4 
               
               
                  32 
                 MTOR,RICTOR,SCRIB 
               
               
                  33 
                 BCR,GBF1,TBC1D4,MTOR,RICTOR,SCRIB,IQSEC1 
               
               
                  34 
                 SRPK2,LOC100046628,NACC1,GM9118,AHCTF1,GM5611,FLNA,GM6477,EIF3A,PTK2,GTF2F1,NPM1, 
               
               
                   
                 GM7289,LOC633387,HELLS,SMARCA4 
               
               
                  35 
                 SRPK2,GM4521,BCR,TRIM28,LOC544757,PKN2,WNK1,RPS6KB1,PRKD2,PTK2,LOC100048123,UKL1, 
               
               
                   
                 AAK1,GSK3B,CDK12,EEF2K,BMP2K,PPP1R12A,MTOR,AKT2 
               
               
                  36 
                 SRPK2,GM4521,BCR,TRIM28,LOC544757,PKN2,WNK1,RPS6KB1,PTK2,LOC100048123,ULK1, 
               
               
                   
                 AAK1,GSK3B,CDK12,EEF2K,BMP2K,PPP1R12A,MTOR,AKT2 
               
               
                  37 
                 DAB2,CTTN,GM8786,ULK1,SNX17,FKBP15,TRIP10,SCRIB 
               
               
                  38 
                 DAB2,CTTN,GM8786,ULK1,SNX17,FKBP15,TRIP10,SCRIB 
               
               
                  39 
                 LOC100046766,SRPK2,PDCD11,LOC100046744,EMG1,SFRS1,LOC100047322,RSL1D1,SFRS8,PCBP1, 
               
               
                   
                 SRRM2,LARP7,LOC100046735,DHX15,SRRM1,LOC100048559 
               
               
                  40 
                 ZFP106,GRB10,PTK2,IRS2,EIF4EBP1,EIF4EBP2,FLNA 
               
               
                  41 
                 EIF4G1,EIF4EBP1,EIF4EBP2,FAM129A,FLNA,FXR1 
               
               
                  42 
                 FOXK1,ULK1,MTOR,DNAJC2 
               
               
                  43 
                 MIB1,DAB2,SRFS1,TCFEB,JUNB,LOC100048559,MLL2,MED1,SMARCA4 
               
               
                  44 
                 MYO5A,LOC100046628,PTK2,GM9118,NPM1,GM5611,GM7289,SCRIB,LOC633387,GM6477 
               
               
                  45 
                 LOC100046628,GM9118,MTAP1B,NPM1,GM5611,SPNA2,GM7289,MTOR,RICTOR,LOC633387, 
               
               
                   
                 GM6477 
               
               
                  46 
                 LOC100046628,ZC3HC1,PDS5B,GM9118,LIN9,GM5611,AHCTF1,RB1,EHMT2,CD2AP,GM6477,NUM 
               
               
                   
                 A1,MACF1,GSK3B,NPM1,GM7289,DNAJC2,HELLS,LOC633387 
               
               
                  47 
                 EIF4G1,EIF4EBP1,EIF4EBP2,FAM129A,FXR1 
               
               
                  48 
                 EIF4EBP1,EIF4EBP2,FXR1 
               
               
                  49 
                 SRPK2,PTK2,EIF3A,AHCTF1,HELLS,FLNA,SMARCA4 
               
               
                  50 
                 LOC100046628,FOXK1,GM9118,ULK1,NPM1,GM5611,GM7289,MTOR,DNAJC2,LOC633387,GM6477 
               
               
                  51 
                 ZFP106,IRS2,EIF4EBP1,EIF4EBP2,LOC100048123,LOC544757,MTOR,AKT2 
               
               
                  52 
                 BCR,GBF1,TBC1D4,MTOR,RICTOR,SCRIB,IQSEC1 
               
               
                  53 
                 MYO5A,INF2,FMNL3,ARHGAP17,RICTOR,INF2Q,FLNA 
               
               
                  54 
                 MIB1,MACF1,TNC,ZEB2,SCRIB,MED1,SMARCA4 
               
               
                  55 
                 IBTK,ZEB2,MTOR,RICTOR,FAM129A 
               
               
                  56 
                 PALM,LOC100046628,LOC100048600,GM9118,SNX17,GM5611,AHCTF1,FLNA,SCRIB,GM6477, 
               
               
                   
                 POM121,ERBB2IP,MACF1,ULK1,RAB1,GSK3B,NPM1,GM7289,SNX30,ERC1,LOC633387 
               
               
                  57 
                 ZC3HC1,PDS5B,AHCTF1,RB1,CD2AP,DNAJC2,HELLS 
               
               
                  58 
                 SRPK2,PTK2,EIF3A,AHCTF1,HELLS,FLNA,SMARCA4 
               
               
                  59 
                 ZFP106,IRS2,EIF4EBP1,EIF4EBP2,LOC100048123,LOC1000544757,MTOR,AKT2 
               
               
                  60 
                 BCLAF1,CARHSP1,FOXK1,FOXK2,AHCTF1,ZEB2,1600027N09RIK,SAP30,SORBS3,GM9791,KDM3B, 
               
               
                   
                 TCFEB,DNAJC2,HELLS,NACC1,PDCD11,TRIM28,CCNL1,RB1,EHMT2,JUNB,FLNA,RFC1,GTF2F1, 
               
               
                   
                 SMARCC2,TMPO,ZFP516,CUX1,NFIC,PBX2,SMARCA4,MED1 
               
               
                  61 
                 MACF1,SCRIB,LLGL1 
               
               
                  62 
                 LOC100046628,LOC100048123,GM9118,NPM1,LOC544757,GM5611,ZEB2,GM7289,MTOR,LOC633387, 
               
               
                   
                 AKT2,GM6477 
               
               
                  63 
                 SAP30,SORBS3,FOXK1,TRIM28,RB1,CUX1,TCFEB,EHMT2,NFIC,PBX2,MED1,SMARCA4 
               
               
                  64 
                 MTOR,RICTOR 
               
               
                  65 
                 MYO5A,LOC100046628,GM9118,ULK1,NPM1,GM5611,GM7289,EHMT2,LOC633387,MED1,GM6477, 
               
               
                   
                 SMARCA4 
               
               
                  66 
                 ZC3HC1,PDS5B,ACHTF1,RB1,EHTMC2,CD2AP,DNAJC2,HELLS 
               
               
                  67 
                 LOC100046628,GM9118,FOXK1,TRIM28,AHCTF1,GM5611,RB1,GM6477,GTF2F1,NPM1,GM7289, 
               
               
                   
                 TCFEB,FAM129A,NFIC,PBX2,LOC633387,MED1 
               
               
                  68 
                 TBC1D4,MTOR,RICTOR,SCRIB 
               
               
                  69 
                 FOXK1,GTF2F1,TRIM28,AHCTF1,MTOR,RB1,RICTOR,TCFEB,FAM129A,NFIC,PBX2,MED1 
               
               
                  70 
                 SRPK2,LOC100046628,PDCD11,EIF3A,GM9118,EMG1,NPM1,GM5611,LOC633387,GM6477 
               
               
                  71 
                 LOC100046628,GM9118,FOXK1,TRIM28,AHCTF1,GM5611,RB1,GM6477,GTF2F1,NPM1,GM7289, 
               
               
                   
                 TCFEB,FAM129A,NFIC,PBX2,LOC633387,MED1 
               
               
                  72 
                 GSK3B,PPP1R12A,FLNA 
               
               
                  73 
                 HELLS,SMARCA4 
               
               
                  74 
                 DAB2,CTTN,GM8786,ULK1,SNX17,FKBP15,TRIP10,SCRIB 
               
               
                  75 
                 ZFP106,GRB10,PTK2,IRS2,EIF4EBP1,EIF4EBP2,FLNA 
               
               
                  76 
                 BCR,MTOR,RICTOR,SCRIB 
               
               
                  77 
                 MIB1,DAB2,ZEB2,SFRS1,TBFEB,JUNB,LOC100048559,MLL2,MED1,SMARCA4 
               
               
                  78 
                 AKT1S1,ZC3HC1,GSK3B,HELLS 
               
               
                  79 
                 MIB1,DAB2,ZEB2,SFRS1,TCFEB,JUNB,LOC100048559,MLL2,MED1,SMARCA4 
               
               
                  80 
                 PTK2,SPNA2,MTOR,RICTOR 
               
               
                  81 
                 BLCAF1,FOXK1,FOXK2,MYEF2,AHCTF1,ZEB2,1600027N09RIK,SAP30,KDM3B,TCFEB,HELLS, 
               
               
                   
                 NACC1,TRIM28,CCNL1,RB1,JUNB,PHF3,RFC1,GTF2F1,SMARCC2,ZFP516,NFIC,CUX1,PBX2, 
               
               
                   
                 MED1 
               
               
                  82 
                 MYO5A,PTK2,TNC,LOC100048740,ADAMTS2,SMARCA4 
               
               
                  83 
                 PDCD11,SQSTM1,FLNA 
               
               
                  84 
                 LOC100046628,BCR,FOXK1,GM9118,NPM1,GM5611,GM7289,RB1,SCRIB,JUNB,LOC633387, 
               
               
                   
                 GM6477 
               
               
                  85 
                 MYO5A,LOC100046628,LOC100048600,GM9118,GM5611,FLNA,GM6477,MACF1,ERBB2IP,GSK3B, 
               
               
                   
                 RAB1,NPM1,GM7289,CUX1,ERC1,LOC633387 
               
               
                  86 
                 RFC1,LIN9,NFIC,DNAJC2,MED1 
               
               
                  87 
                 MIB1,MACF1,ZEB2,EXT1,PBX2,SCRIB,MED1,SMARCA4 
               
               
                  88 
                 TBC1D4,MTOR,RICTOR,SCRIB 
               
               
                  89 
                 PTK2,ULK1,MTAP1B,SPNA2 
               
               
                  90 
                 GSK3B,PPP1R12A,FLNA 
               
               
                  91 
                 LOC100046628,GM9118,MTAP1B,NPM1,GM5611,SPNA2,GM7289,MTOR,RICTOR,LOC633387, 
               
               
                   
                 GM6477 
               
               
                  92 
                 IBTK,LOC100046628,GM9118,GM5611,ZEB2,RICTOR,RB1,GM6477,NPM1,GM7289,MTOR, 
               
               
                   
                 FAM129A,LOC633387 
               
               
                  93 
                 FOXK1,RB1,SCRIB 
               
               
                  94 
                 PTK2,JUNB,SMARCA4 
               
               
                  95 
                 EIF4EBP1,EIF4EBP2 
               
               
                  96 
                 LOC100046628,PTK2,NACC1,GM9118,GTF2F1,NPM1,AHCTF1,GM5611,GM7289,LOC633387,FLNA, 
               
               
                   
                 GM6477 
               
               
                  97 
                 LOC100046628,PTK2,NACC1,GM9118,GTF2F1,NPM1,AHCTF1,GM5611,GM7289,LOC633387,FLNA, 
               
               
                   
                 GM6477 
               
               
                  98 
                 SPNA2,MTOR,RICTOR 
               
               
                  99 
                 FOXK1,GTF2F1,TRIM28,AHCTF1,RB1,TCFEB,FAM129A,NFIC,PBX2,MED1 
               
               
                 100 
                 IBTK,LOC100046628,GM9118,GM5611,ZEB2,RICTOR,RB1,GM6477,NPM1,GM7289,MTOR, 
               
               
                   
                 FAM129A,LOC633387 
               
               
                 101 
                 IBTK,LOC100046628,GM9118,GM5611,ZEB2,RICTOR,RB1,GM6477,NPM1,GM7289,MTOR, 
               
               
                   
                 FAM129A,LOC633387 
               
               
                 102 
                 MYO5A,ULK1,MED1,SMARCA4 
               
               
                 103 
                 MTOR,RICTOR 
               
               
                 104 
                 FOXK1,ULK1,DNAJC2 
               
               
                 105 
                 INF2,FMNL3,ARHGAP17,RICTOR,INF2Q,FLNA 
               
               
                 106 
                 IBTK,ZEB2,MTOR,RICTOR,FAM129A 
               
               
                 107 
                 DAB2,PTK2,MACF1,ULK1,TRIM28,SCRIB,LLGL1 
               
               
                 108 
                 PTK2,TNS1,ULK1,ZEB2,CD2AP,SCRIB 
               
               
                 109 
                 SPNA2,MTOR,RICTOR 
               
               
                 110 
                 SPNA2,MTOR,RICTOR 
               
               
                 111 
                 MIB1,TNC,ZEB2,SCRIB,MED1 
               
               
                 112 
                 SMARCC2,CHD1,HELLS,SMARCA4 
               
               
                 113 
                 LOC100046628,GM9118,NPM1,GM5611,GM7289,MTOR,RICTOR,LOC633387,GM6477 
               
               
                 114 
                 FOXK1,GTF2F1,TRIM28,AHCTF1,RB1,TCFEB,NFIC,PBX2,MED1 
               
               
                 115 
                 MYO5A,ARHGAP17,SCRIB,LLGL1 
               
               
                 116 
                 IRS2,GSK3B,ZEB2,SCRIB,HELLS,MED1 
               
               
                 117 
                 MTOR,RICTOR 
               
               
                 118 
                 LOC100046628,PTK2,GM9118,MTAP1B,NPM1,GM5611,GM7289,LOC633387,RANBP10,GM6477 
               
               
                 119 
                 MIB1,ZEB2,SCRIB,MED1 
               
               
                   
               
            
           
           
               
            
               
                 Rapa BP GO pathways (c): 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                   
                 List 
                 Pop 
                 Pop 
                 Fold 
                   
                   
                   
               
               
                 ID 
                 Total 
                 Hits 
                 Total 
                 Enrichment 
                 Bonferroni 
                 Benjamini 
                 FDR 
               
               
                   
               
               
                 1 
                 133 
                 506 
                 13588 
                  4.038158638 
                 0.000424 
                 4.24E−04 
                  6.62E-04 
               
               
                 2 
                 133 
                 430 
                 13588 
                  4.039097744 
                 0.00422262 
                 0.002113544 
                  0.006599221 
               
               
                 3 
                 133 
                 418 
                 13588 
                  3.910637839 
                 0.013202715 
                 0.003317148 
                  0.020725619 
               
               
                 4 
                 133 
                 397 
                 13588 
                  3.860154164 
                 0.031339368 
                 0.006347957 
                  0.049646045 
               
               
                 5 
                 133 
                 59 
                 13588 
                 10.38970307 
                 0.234820063 
                 0.037513168 
                  0.4165415 
               
               
                 6 
                 133 
                 372 
                 13588 
                  3.57029671 
                 0.240156236 
                 0.033747706 
                  0.427409635 
               
               
                 7 
                 133 
                 466 
                 13588 
                  3.069347188 
                 0.458108033 
                 0.065811007 
                  0.950983483 
               
               
                 8 
                 133 
                 43 
                 13588 
                 11.87969925 
                 0.548457185  
                 0.069730046 
                  1.232339007 
               
               
                 9 
                 133 
                 310 
                 13588 
                  3.625224351 
                 0.593238056 
                 0.072219958 
                  1.393086083 
               
               
                 10 
                 133 
                 78 
                 13588 
                  7.858877964 
                 0.622688909 
                 0.072234052 
                  1.508600184 
               
               
                 11 
                 133 
                 21 
                 13588 
                 19.46007877 
                 0.655224183 
                 0.073240783 
                  1.647016896 
               
               
                 12 
                 133 
                 640 
                 13588 
                  2.554135338 
                 0.752083804 
                 0.08878612 
                  2.151600307 
               
               
                 13 
                 133 
                 404 
                 13588 
                  3.034616244 
                 0.860222342 
                 0.115719883 
                  3.022171324 
               
               
                 14 
                 133 
                 236 
                 13588 
                  3.896138652 
                 0.885866021 
                 0.119855821 
                  3.328229194 
               
               
                 15 
                 133 
                 95 
                 13588 
                  6.452552434 
                 0.904450787  
                 0.122300298 
                  3.595818606 
               
               
                 16 
                 133 
                 58 
                 13588 
                  8.807363236 
                 0.913322224 
                 0.120774231 
                  3.742213886 
               
               
                 17 
                 133 
                 28 
                 13588 
                 14.59505908 
                 0.917735112 
                 0.117406498 
                  3.820625016 
               
               
                 18 
                 133 
                 308 
                 13588 
                  3.317058881 
                 0.958217785 
                 0.140327713 
                  4.831479072 
               
               
                 19 
                 133 
                 315 
                 13588 
                  3.243346461 
                 0.974869971 
                 0.154173087 
                  5.583086162 
               
               
                 20 
                 133 
                 66 
                 13588 
                  7.739804056 
                 0.980097008 
                 0.156587702  
                  5.925840566 
               
               
                 21 
                 133 
                 155 
                 13588 
                  4.613921902 
                 0.983355842 
                 0.15688676 
                  6.187818747 
               
               
                 22 
                 133 
                 718 
                 13588 
                  2.276666597 
                 0.984989728 
                 0.154613045 
                  6.33886821 
               
               
                 23 
                 133 
                 34 
                 13588 
                 12.01946042 
                 0.987440816  
                 0.154948588 
                  6.59892672 
               
               
                 24 
                 133 
                 326 
                 13588 
                  3.133908391 
                 0.990050495 
                 0.156967149 
                  6.937610234 
               
               
                 25 
                 133 
                 161 
                 13588 
                  4.441974501 
                 0.992759227 
                 0.161382833 
                  7.397709501 
               
               
                 26 
                 133 
                 393 
                 13588 
                  2.859591727 
                 0.993737166 
                 0.16048863 
                  7.607019539 
               
               
                 27 
                 133 
                 71 
                 13588 
                  7.194747432 
                 0.993846998 
                 0.156076846 
                  7.632510001 
               
               
                 28 
                 133 
                 72 
                 13588 
                  7.094820384 
                 0.995256964 
                 0.158538831 
                  8.006669044 
               
               
                 29 
                 133 
                 338 
                 13588 
                  3.022645371 
                 0.997031505 
                 0.166286638 
                  8.676553117 
               
               
                 30 
                 133 
                 280 
                 13588 
                  3.283888292 
                 0.997784278 
                 0.169076444 
                  9.092166954 
               
               
                 31 
                 133 
                 231 
                 13588 
                  3.53819614 
                 0.999435936 
                 0.197489303 
                 11.01137247 
               
               
                 32 
                 133 
                 14 
                 13588 
                 21.89258861 
                 0.999679622 
                 0.205375826  
                 11.79297815 
               
               
                 33 
                 133 
                 181 
                 13588 
                  3.95114859 
                 0.99981874 
                 0.212838341 
                 12.57303844 
               
               
                 34 
                 133 
                 367 
                 13588 
                  2.783798734 
                 0.999942481 
                 0.231930955 
                 14.12415408 
               
               
                 35 
                 133 
                 866 
                 13588 
                  2.005556617 
                 0.999952335 
                 0.230394008 
                 14.37545544 
               
               
                 36 
                 133 
                 866 
                 13588 
                  2.005556617 
                 0.999952335 
                 0.230394008 
                 14.37545544 
               
               
                 37 
                 133 
                 188 
                 13588 
                  3.804031355 
                 0.999965843 
                 0.231800837 
                 14.81929399 
               
               
                 38 
                 133 
                 188 
                 13588 
                  3.804031355 
                 0.999965843 
                 0.231800837 
                 14.81929399 
               
               
                 39 
                 133 
                 437 
                 13588 
                  2.571669448 
                 0.999969761 
                 0.229071539 
                 14.98100495 
               
               
                 40 
                 133 
                 192 
                 13588 
                  3.724780702 
                 0.99998807 
                 0.241565162 
                 16.20528578 
               
               
                 41 
                 133 
                 148 
                 13588 
                  4.141841089 
                 0.999999702 
                 0.300740537 
                 20.88938812 
               
               
                 42 
                 133 
                 53 
                 13588 
                  7.710597248 
                 0.999999716 
                 0.295721164 
                 20.95127119 
               
               
                 43 
                 133 
                 267 
                 13588 
                  3.061135986 
                 0.999999858 
                 0.301224134 
                 21.80434851 
               
               
                 44 
                 133 
                 54 
                 13588 
                  7.56780841 
                 0.99999987 
                 0.296980281 
                 21.90910181 
               
               
                 45 
                 133 
                 99 
                 13588 
                  5.15986937 
                 0.9999999 
                 0.295639893 
                 22.230872 
               
               
                 46 
                 133 
                 611 
                 13588 
                  2.173732203 
                 0.999999904 
                 0.290960801 
                 22.27849302 
               
               
                 47 
                 133 
                 100 
                 13588 
                  5.108270677 
                 0.999999943 
                 0.293467107 
                 22.89881268 
               
               
                 48 
                 133 
                 22 
                 13588 
                 13.9316473 
                 0.999999997 
                 0.328676558 
                 26.2532865 
               
               
                 49 
                 133 
                 217 
                 13588 
                  3.295658501 
                 0.999999997 
                 0.325881168 
                 26.47233348 
               
               
                 50 
                 133 
                 108 
                 13588 
                  4.729880256 
                 1 
                 0.344482216 
                 28.53155823 
               
               
                 51 
                 133 
                 165 
                 13588 
                  3.715105947 
                 1 
                 0.357404888 
                 30.13796653 
               
               
                 52 
                 133 
                 228 
                 13588 
                  3.136657433 
                 1 
                 0.370168333 
                 31.75922119 
               
               
                 53 
                 133 
                 176 
                 13588 
                  3.482911825 
                 1 
                 0.420100589 
                 36.80211781 
               
               
                 54 
                 133 
                 238 
                 13588 
                  3.004865104 
                 1 
                 0.41509568 
                 36.87329018 
               
               
                 55 
                 133 
                 121 
                 13588 
                  4.221711303 
                 1 
                 0.427055137 
                 38.51844258 
               
               
                 56 
                 133 
                 753 
                 13588 
                  1.89948976 
                 1 
                 0.432566345 
                 39.57163653 
               
               
                 57 
                 133 
                 244 
                 13588 
                  2.930974978 
                 1 
                 0.431978548 
                 40.04717075 
               
               
                 58 
                 133 
                 245 
                 13588 
                  2.919011815 
                 1 
                 0.432065576 
                 40.58206094 
               
               
                 59 
                 133 
                 184 
                 13588 
                  3.331480876 
                 1 
                 0.439852811 
                 41.86001448 
               
               
                 60 
                 133 
                 2227 
                 13588 
                  1.422149897 
                 1 
                 0.452125635 
                 43.58475519 
               
               
                 61 
                 133 
                 31 
                 13588 
                  9.886975503 
                 1 
                 0.453613528 
                 44.25845315 
               
               
                 62 
                 133 
                 75 
                 13588 
                  5.448822055 
                 1 
                 0.450365735 
                 44.4589569 
               
               
                 63 
                 133 
                 616 
                 13588 
                  1.990235329 
                 1 
                 0.454144887 
                 45.35260328 
               
               
                 64 
                 133 
                 4 
                 13588 
                 51.08270677 
                 1 
                 0.456547995 
                 46.10772521 
               
               
                 65 
                 133 
                 193 
                 13588 
                  3.176126846 
                 1 
                 0.466771241 
                 47.65120316 
               
               
                 66 
                 133 
                 328 
                 13588 
                  2.491839354 
                 1 
                 0.469084762 
                 48.39705082 
               
               
                 67 
                 133 
                 552 
                 13588 
                  2.03590498 
                 1 
                 0.477872288 
                 49.80054252 
               
               
                 68 
                 133 
                 80 
                 13588 
                  5.108270677 
                 1 
                 0.475050206 
                 50.01764292 
               
               
                 69 
                 133 
                 633 
                 13588 
                  1.936785091 
                 1 
                 0.480392471 
                 51.06697676 
               
               
                 70 
                 133 
                 137 
                 13588 
                  3.728664728 
                 1 
                 0.478500703 
                 51.36875 
               
               
                 71 
                 133 
                 557 
                 13588 
                  2.017629352 
                 1 
                 0.476086095 
                 51.60967499 
               
               
                 72 
                 133 
                 35 
                 13588 
                  8.757035446 
                 1 
                 0.474622436 
                 51.94267678 
               
               
                 73 
                 133 
                 5 
                 13588 
                 40.86616541 
                 1 
                 0.488078471 
                 53.82618784 
               
               
                 74 
                 133 
                 272 
                 13588 
                  2.629256966 
                 1 
                 0.497115601 
                 55.24796589 
               
               
                 75 
                 133 
                 273 
                 13588 
                  2.619625988 
                 1 
                 0.497699806 
                 55.7861226 
               
               
                 76 
                 133 
                 86 
                 13588 
                  4.751879699 
                 1 
                 0.50004125 
                 56.50311848 
               
               
                 77 
                 133 
                 421 
                 13588 
                  2.184058722 
                 1 
                 0.506829853 
                 57.6805401 
               
               
                 78 
                 133 
                 88 
                 13588 
                  4.643882433 
                 1 
                 0.511161168 
                 58.59697919 
               
               
                 79 
                 133 
                 425 
                 13588 
                  2.163502875 
                 1 
                 0.514070595 
                 59.36036942 
               
               
                 80 
                 133 
                 89 
                 13588 
                  4.591703979 
                 1 
                 0.512284313 
                 59.62851936 
               
               
                 81 
                 133 
                 1772 
                 13588 
                  1.441385631 
                 1 
                 0.509804241 
                 59.81828305 
               
               
                 82 
                 133 
                 149 
                 13588 
                  3.428369582 
                 1 
                 0.51404321 
                 60.70683174 
               
               
                 83 
                 133 
                 40 
                 13588 
                  7.662406015 
                 1 
                 0.510980221 
                 60.82544158 
               
               
                 84 
                 133 
                 214 
                 13588 
                  2.864450847 
                 1 
                 0.507942029 
                 60.94067925 
               
               
                 85 
                 133 
                 431 
                 13588 
                  2.133384505 
                 1 
                 0.512485719 
                 61.84796511 
               
               
                 86 
                 133 
                 152 
                 13588 
                  3.360704393 
                 1 
                 0.518823826 
                 62.93700974 
               
               
                 87 
                 133 
                 359 
                 13588 
                  2.276666597 
                 1 
                 0.515146769 
                 62.97259844 
               
               
                 88 
                 133 
                 93 
                 13588 
                  4.394211335 
                 1 
                 0.51755278 
                 63.64021648 
               
               
                 89 
                 133 
                 93 
                 13588 
                  4.394211335 
                 1 
                 0.51755278 
                 63.64021648 
               
               
                 90 
                 133 
                 42 
                 13588 
                  7.297529538 
                 1 
                 0.518038348 
                 64.10197022 
               
               
                 91 
                 133 
                 154 
                 13588 
                  3.317058881 
                 1 
                 0.516945411 
                 64.39400928 
               
               
                 92 
                 133 
                 290 
                 13588 
                  2.466061706 
                 1 
                 0.515677628 
                 64.66313432 
               
               
                 93 
                 133 
                 43 
                 13588 
                  7.127819549 
                 1 
                 0.521573895 
                 65.67569163 
               
               
                 94  
                 133 
                 43 
                 13588 
                  7.127819549 
                 1 
                 0.521573895 
                 65.67569163 
               
               
                 95 
                 133 
                 7 
                 13588 
                 29.19011815 
                 1 
                 0.521941211 
                 66.10627789 
               
               
                 96 
                 133 
                 227 
                 13588 
                  2.700407406 
                 1 
                 0.541900011 
                 68.54571328 
               
               
                 97 
                 133 
                 227 
                 13588 
                  2.700407406 
                 1 
                 0.541900011 
                 68.54571328 
               
               
                 98 
                 133 
                 45 
                 13588 
                  6.811027569 
                 1 
                 0.539576096 
                 68.69004358 
               
               
                 99 
                 133 
                 530 
                 13588 
                  1.927649312 
                 1 
                 0.548723845 
                 69.99148633 
               
               
                 100 
                 133 
                 301 
                 13588 
                  2.37593985 
                 1 
                 0.545243603 
                 70.01150996 
               
               
                 101 
                 133 
                 301 
                 13588 
                  2.37593985 
                 1 
                 0.545243603 
                 70.01150996 
               
               
                 102 
                 133 
                 100 
                 13588 
                  4.086616541 
                 1 
                 0.543036347 
                 70.15551118 
               
               
                 103 
                 133 
                 8 
                 13588 
                 25.54135338 
                 1 
                 0.547458295 
                 70.9615401 
               
               
                 104 
                 133 
                 47 
                 13588 
                  6.521196609 
                 1 
                 0.549517711 
                 71.52373165 
               
               
                 105 
                 133 
                 165 
                 13588 
                  3.095921622 
                 1 
                 0.549873189 
                 71.91098296 
               
               
                 106 
                 133 
                 165 
                 13588 
                  3.095921622 
                 1 
                 0.549873189 
                 71.91098296 
               
               
                 107 
                 133 
                 309 
                 13588 
                  2.314426844 
                 1 
                 0.563991497 
                 73.64287114 
               
               
                 108 
                 133 
                 240 
                 13588 
                  2.554135338 
                 1 
                 0.578472896 
                 75.36897392 
               
               
                 109 
                 133 
                 50 
                 13588 
                  6.129924812 
                 1 
                 0.575662811 
                 75.43274213 
               
               
                 110 
                 133 
                 51 
                 13588 
                  6.009730208 
                 1 
                 0.58511535 
                 76.64517662 
               
               
                 111 
                 133 
                 173 
                 13588 
                  2.952757617 
                 1 
                 0.583088756 
                 76.77534105 
               
               
                 112 
                 133 
                 109 
                 13588 
                  3.749189487 
                 1 
                 0.586996658 
                 77.45061982 
               
               
                 113 
                 133 
                 52 
                 13588 
                  5.894158473 
                 1 
                 0.587580562 
                 77.81289666 
               
               
                 114 
                 133 
                 475 
                 13588 
                  1.93576573 
                 1 
                 0.58770496 
                 78.12859078 
               
               
                 115 
                 133 
                 110 
                 13588 
                  3.715105947 
                 1 
                 0.584982961 
                 78.1816002 
               
               
                 116 
                 133 
                 247 
                 13588 
                  2.481750936 
                 1 
                 0.587000314 
                 78.66120379 
               
               
                 117 
                 133 
                 10 
                 13588 
                 20.43308271 
                 1 
                 0.584028864 
                 78.68588514 
               
               
                 118 
                 133 
                 111 
                 13588 
                  3.681636524 
                 1 
                 0.583150293 
                 78.89645491 
               
               
                 119 
                 133 
                 111 
                 13588 
                  3.681636524 
                 1 
                 0.583150293 
                 78.89645491 
               
               
                   
               
            
           
           
               
            
               
                 Rapa KEGG pathways (a): 
               
            
           
           
               
               
               
               
               
               
            
               
                 ID 
                 Term 
                 Count 
                 % 
                 PValue 
                 minuslog10P 
               
               
                   
               
               
                 1 
                 mmu04150:mTOR signaling pathway 
                 7 
                 3.51758794 
                 1.57E−06 
                 5.8 
               
               
                 2 
                 mmu04012:ErbB signaling pathway 
                 6 
                 3.015075377 
                 3.09E−04 
                 3.51 
               
               
                 3 
                 mmu04910:Insulin signaling pathway 
                 7 
                 3.51758794 
                 3.40E−04 
                 3.47 
               
               
                 4 
                 mmu05221:Acute myeloid leukemia 
                 4 
                 2.010050251 
                 0.007078848 
                 2.15 
               
               
                 5 
                 mmu04510:Focal adhesion 
                 6 
                 3.015075377 
                 0.011465215 
                 1.94 
               
               
                 6 
                 mmu04530:Tight junction 
                 5 
                 2.512562814 
                 0.013906132 
                 1.86 
               
               
                 7 
                 mmu052GO:Pathways in cancer 
                 7 
                 3.51758794 
                 0.02305239 
                 1.64 
               
               
                 8 
                 mmu05215:Prostate cancer 
                 4 
                 2.010050251 
                 0.024273508 
                 1.61 
               
               
                 9 
                 mmu03018:RNA degradation 
                 3 
                 1.507537688 
                 0.065096102 
                 1.19 
               
               
                 10 
                 mmu05214:Glioma 
                 3 
                 1.507537688 
                 0.072876584 
                 1.14 
               
               
                 11 
                 mmu04920:Adipocytokine signaling  
                 3 
                 1.507537688 
                 0.078901015 
                 1.1 
               
               
                   
                 pathway 
                   
                   
                   
                   
               
               
                 12 
                 mmu04370:VEGF signaling pathway 
                 3 
                 1.507537688 
                 0.097853719 
                 1.01 
               
               
                 13 
                 mmu05220:Chronic myeloid leukemia 
                 3 
                 1.507537688 
                 0.097853719 
                 1.01 
               
               
                   
               
            
           
           
               
            
               
                 Rapa KEGG pathways (b): 
               
            
           
           
               
               
            
               
                 ID 
                 Genes 
               
               
                   
               
               
                 1 
                 IPI00453603,IPI00318938,IPI00399440,IPI00268673,IPI00467843,IPI00221581,IPI00121335 
               
               
                 2 
                 IPI00125319,IPI00453603,IPI00318938,IPI00113563,IPI00268673,IPI00121335 
               
               
                 3 
                 IPI00125319,IPI00453603,IPI00116923,IPI00318938,IPI00268673,IPI00379844,IPI00121335 
               
               
                 4 
                 IPI00453603,IPI00318938,IPI00268673,IPI00121335 
               
               
                 5 
                 IPI00403938,IPI00125319,IPI00131138,IPI00113563,IPI00671847,IPI00121335 
               
               
                 6 
                 IPI00118143,IPI00380354,IPI00323349,IPI00845596,IPI00121335 
               
               
                 7 
                 IPI00125319,IPI00121418,IPI00381495,IPI00113563,IPI00268673,IPI00380817,IPI00121335 
               
               
                 8 
                 IPI00125319,IPI00121418,IP100268673,IPI00121335 
               
               
                 9 
                 IPI00169888,IPI00309059,IPI00330066 
               
               
                 10 
                 IPI00121418,IPI00268673,IPI00121335 
               
               
                 11 
                 IPI00268673,IPI00379844,IPI00121335 
               
               
                 12 
                 IPI00111169,IPI00113563,IPI00121335 
               
               
                 13 
                 IPI00121418,IPI00380817,IPI00121335 
               
               
                   
               
            
           
           
               
            
               
                 Rapa KEGG pathways (c): 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 ID 
                 List Total 
                 Pop Hits 
                 Pop Total 
                 Fold Enrichment 
                 Bonferroni 
                 Benjamini 
                 FDR 
               
               
                   
               
               
                 1 
                 41 
                 54 
                 5738 
                 18.14182475 
                 1.10E−04 
                 1.10E−04 
                  0.001624292 
               
               
                 2 
                 41 
                 87 
                 5738 
                  9.651808242 
                 0.02142063 
                 0.010768293 
                  0.319622391 
               
               
                 3 
                 41 
                 138 
                 5738 
                  7.098974903 
                 0.023507108 
                 0.007897915 
                  0.35107298 
               
               
                 4 
                 41 
                 57 
                 5738 
                  9.821138211 
                 0.391818277 
                 0.116903139 
                  7.088295684 
               
               
                 5 
                 41 
                 198 
                 5738 
                  4.240946046 
                 0.553895165 
                 0.149082636 
                 11.24945571 
               
               
                 6 
                 41 
                 135 
                 5738 
                  5.1833785 
                 0.624786839 
                 0.150728903 
                 13.49142317 
               
               
                 7 
                 41 
                 323 
                 5738 
                  3.032998565 
                 0.804570905 
                 0.208022678 
                 21.44454537 
               
               
                 8 
                 41 
                 90 
                 5738 
                  6.220054201 
                 0.820953112 
                 0.193469404 
                 22.45479997 
               
               
                 9 
                 41 
                 60 
                 5738 
                  6.997560976 
                 0.991011485 
                 0.407576887 
                 50.1731853 
               
               
                 10 
                 41 
                 64 
                 5738 
                  6.560213415 
                 0.994992413 
                 0.411206711 
                 54.30152323 
               
               
                 11 
                 41 
                 67 
                 5738 
                  6.266472515 
                 0.99682721 
                 0.407268104 
                 57.28300003 
               
               
                 12 
                 41 
                 76 
                 5738 
                  5.524390244 
                 0.999259735 
                 0.451577052 
                 65.55273205 
               
               
                 13 
                 41 
                 76 
                 5738 
                  5.524390244 
                 0.999259735 
                 0.451577052 
                 65.55273205 
               
               
                   
               
            
           
           
               
            
               
                 Ku BP GO (a): 
               
            
           
           
               
               
               
               
               
            
               
                 ID 
                 Term 
                 Count 
                 % 
                 PValue 
               
               
                   
               
               
                 1 
                 GO:0030032~lamellipodium assembly 
                 3 
                  3.092783505 
                 3.25E−03 
               
               
                 2 
                 GO:0006468~protein amino acid phosphorylation 
                 10 
                 10.30927835 
                 7.09E−03 
               
               
                 3 
                 GO:0008286~insulin receptor signaling pathway 
                 3 
                  3.092783505 
                 9.83E−03 
               
               
                 4 
                 GO:0030029~actin filament-based process 
                 5 
                  5.154639175 
                 0.014807537 
               
               
                 5 
                 GO:0006913~nucleocytoplasmic transport 
                 4 
                  4.12371134 
                 0.014880914 
               
               
                 6 
                 GO:0051493~regulation of cytoskeleton  
                 4 
                  4.12371134 
                 0.016150894 
               
               
                   
                 organization 
                   
                   
                   
               
               
                 7 
                 GO:0006796~phosphate metabolic process 
                 11 
                 11.34020619 
                 0.016942852 
               
               
                 8 
                 GO:0006259~DNA metabolic process 
                 7 
                  7.216494845 
                 0.025415897 
               
               
                 9 
                 GO:0045947~negative regulation of transla- 
                 2 
                  2.06185567 
                 0.037014038 
               
               
                   
                 tional initiation 
                   
                   
                   
               
               
                 10 
                 GO:0007049~cell cycle 
                 8 
                  8.24742268 
                 0.04530749 
               
               
                 11 
                 GO:0033043~regulation of organelle organization 
                 4 
                  4.12371134 
                 0.049959502 
               
               
                 12 
                 GO:0043484~regulation of RNA splicing 
                 2 
                  2.06185567 
                 0.052460451 
               
               
                 13 
                 GO:0010605~negative regulation of macro- 
                 7 
                  7.216494845 
                 0.05420299 
               
               
                   
                 molecule metabolic process 
                   
                   
                   
               
               
                 14 
                 GO:0030031~cell projection assembly 
                 3 
                  3.092783505 
                 0.054397233 
               
               
                 15 
                 GO:0022402~cell cycle process 
                 6 
                  6.18556701 
                 0.059968997 
               
               
                 16 
                 GO:0033554~cellular response to stress 
                 6 
                  6.18556701 
                 0.065899107 
               
               
                 17 
                 GO:0045884~regulation of survival gene product 
                 2 
                  2.06185567 
                 0.072676117 
               
               
                   
                 expression 
                   
                   
                   
               
               
                 18 
                 GO:0010558~negative regulation of macro- 
                 6 
                  6.18556701 
                 0.073909203 
               
               
                   
                 molecule biosynthetic process 
                   
                   
                   
               
               
                 19 
                 GO:0006916~anti-apoptosis 
                 3 
                  3.092783505 
                 0.081129603 
               
               
                 20 
                 GO:0031327~negative regulation of cellular  
                 6 
                  6.18556701 
                 0.081184023 
               
               
                   
                 biosynthetic process 
                   
                   
                   
               
               
                 21 
                 GO:0046907~intracellular transport 
                 6 
                  6.18556701 
                 0.081807159 
               
               
                 22 
                 GO:0009890~negative regulation of biosynthetic  
                 6 
                  6.18556701 
                 0.083692072 
               
               
                   
                 process 
                   
                   
                   
               
               
                 23 
                 GO:0006396~RNA processing 
                 6 
                  6.18556701 
                 0.085600178 
               
               
                 24 
                 GO:0051129~negative regulation of cellular  
                 3 
                  3.092783505 
                 0.089153114 
               
               
                   
                 component organization 
                   
                   
                   
               
               
                 25 
                 GO:0006325~chromatin organization 
                 5 
                  5.154639175 
                 0.08921682 
               
               
                 26 
                 GO:0030030~cell projection organization 
                 5 
                  5.154639175 
                 0.092408475 
               
               
                 27 
                 GO:0043434~response to peptide hormone  
                 3 
                  3.092783505 
                 0.092426596 
               
               
                   
                 stimulus 
                   
                   
                   
               
               
                 28 
                 GO:0016569~covalent chromatin modification 
                 3 
                  3.092783505 
                 0.094076504 
               
               
                 29 
                 GO:0043271~negative regulation of ion transport 
                 2 
                  2.06185567 
                 0.097348357 
               
               
                 30 
                 GO:0007010~cytoskeleton organization 
                 5 
                  5.154639175 
                 0.098124703 
               
               
                   
               
            
           
           
               
            
               
                 Ku BP GO (b): 
               
            
           
           
               
               
            
               
                 ID 
                 Genes 
               
               
                   
               
               
                 1 
                 CCDC88A,NCK1,VCL 
               
               
                 2 
                 ALPK3,BAZ1B,BRAF,MAP3K2,SPNB2,GSK3B,NEK9,RPS6KB1,C230081A13RIK,MELK 
               
               
                 3 
                 PHIP,EIF4EBPI,EIF4EBP2 
               
               
                 4 
                 EPB4.1L3,NCK1,ARHGEF17,MY09B,FLNC 
               
               
                 5 
                 LOCI 00046628,GM9118,SPNB2,GSK3B,NPM1,GM5611,GM7289,MYBBP1A,LOC633387,GM6477 
               
               
                 6 
                 LOCI 00046628, CCDC88A,GM9118,SPNB2,MTAP1B,NPM1,GM5611,GM7289,LOC633387, 
               
               
                   
                 GM6477 
               
               
                 7 
                 ALPK3,BAZ1B,BRAF,MAP3K2,SPNB2,GSK3B,SYNJ1,NEK9,RPS6KB1,C230081A13R1K,MELK 
               
               
                 8 
                 ATRX,TRP53BP1,CCDC88A,MDC1,ORC6L,TOP2B,MYC 
               
               
                 9 
                 ElF4EBP1,E1F4EBP2 
               
               
                 10 
                 LOC100046628,GM9118,RBL1,GM5611,ZFP318,GM6477,MDC1,GSK3B,NPM1,KIF20B,NEK9,  
               
               
                   
                 GM7289,LOC633387,ERCC6L 
               
               
                 11 
                 LOC100046628,CCDC88A,GM9118,SPNB2,MTAP1B,NPM1,GM5611,GM7289,LOC633387,GM6477 
               
               
                 12 
                 LOC100046628,GM9118,GPX4,NPM1,GM5611,GM7289,HNRPLL,LOC633387,GM6477 
               
               
                 13 
                 LOC100046628,GM9118,RBL1,GM5611,GM6477,EIF4EBP1,EIF4EBP2,NPM1,GM7289,MYC,MYBB  
               
               
                   
                 P1A, LOC633387,SMARCA4 
               
               
                 14 
                 CCDC88A,NCK1,VCL 
               
               
                 15 
                 LOC100046628,GM9118,GSK3B,NPM1,KIF20B,NEK9,GM5611,GM7289,ZFP318,LOC633387, 
               
               
                   
                 GM6477,ERCC6L 
               
               
                 16 
                 ATRX,TRP53BP1,BAZ1B,MDC1,GPX4,GSK3B,HNRPLL 
               
               
                 17 
                 AKT1S1,MYC 
               
               
                 18 
                 EIF4EBP1,EIF4EBP2,RBL1,MYBBP1A,MYC,SMARCA4 
               
               
                 19 
                 AKT1S1,GSK3B,MYC 
               
               
                 20 
                 EIF4EBP1,EIF4EBP2,RBL1,MYBBP1A,MYC,SMARCA4 
               
               
                 21 
                 LOC100046628,GM9118,SPNB2,GSK3B,NPM1,AKAP12,GM5611,MYO9B,GM7289,MYBBP1A, 
               
               
                   
                 LOC633387,GM6477 
               
               
                 22 
                 EIF4EBP1,EIF4EBP2,RBL1,MYBBP1A,MYC,SMARCA4 
               
               
                 23 
                 LOC100046766,SF3B1,EXOSC9,LOC100046744,GPX4,LARP7,SRRM2,LOC100046735,POP1, 
               
               
                   
                 LOC675032,LOC100047322,HNRPLL 
               
               
                 24 
                 RTN4,SPNB2,MTAP1B 
               
               
                 25 
                 BAZ1B,GPX4,RBL1,SETD2,HNRPLL,SMARCA4 
               
               
                 26 
                 CCDC88A,NCK1,MTAP1B,TOP2B,VCL 
               
               
                 27 
                 PHIP,EIF4EBP1,EIF4EBP2 
               
               
                 28 
                 BAZ1B,SETD2,SMARCA4 
               
               
                 29 
                 BEST3,NEDD4L 
               
               
                 30 
                 EPB4.1L3,LOC100046628,GM9118,NCK1,MTAP1B,NPM1,ARHGEF17,GM5611,GM7289,LOC633387, 
               
               
                   
                 GM6477 
               
               
                   
               
            
           
           
               
            
               
                 Ku BP GO (c): 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 ID 
                 List Total 
                 Pop Hits 
                 Pop Total 
                 Fold Enrichment 
                 Bonferroni 
                 Benjamini 
                 FDR 
               
               
                   
               
               
                 1 
                 74 
                 16 
                 13588 
                  34.42905405 
                 0.882872164 
                 8.83E−01 
                 4.76E+3000 
               
               
                 2 
                 74 
                 640 
                 13588 
                  2.869087838 
                 0.990722194 
                 0.903678632 
                 10.0912277 
               
               
                 3 
                 74 
                 28 
                 13588 
                 19.67374517 
                 0.998498942 
                 0.885501679 
                 13.73744045 
               
               
                 4 
                 74 
                 176 
                 13588 
                  5.216523342 
                 0.99994544 
                 0.859597701 
                 19.99753834 
               
               
                 5 
                 74 
                 96 
                 13588 
                  7.650900901 
                 0.99994805 
                 0.806833826 
                 20.08660666 
               
               
                 6 
                 74 
                 99 
                 13588 
                  7.419055419 
                 0.999977769 
                 0.737959309 
                 21.61357964 
               
               
                 7 
                 74 
                 866 
                 13588 
                  2.332376256 
                 0.999986913 
                 0.713301589 
                 22.55196875 
               
               
                 8 
                 74 
                 421 
                 13588 
                  3.053091096 
                 0.999999956 
                 0.785616066 
                 31.95670058 
               
               
                 9 
                 74 
                 7 
                 13588 
                 52.46332046 
                 1 
                 0.87357656 
                 43.11139373 
               
               
                 10 
                 74 
                 611 
                 13588 
                  2.404211085 
                 1 
                 0.869178376 
                 50.01437111 
               
               
                 11 
                 74 
                 154 
                 13588 
                  4.769392769 
                 1 
                 0.878480874 
                 53.53582478 
               
               
                 12 
                 74 
                 10 
                 13588 
                 36.72432432 
                 1 
                 0.875783402 
                 55.33191067 
               
               
                 13 
                 74 
                 506 
                 13588 
                  2.540220062 
                 1 
                 0.869599238 
                 56.5448088 
               
               
                 14 
                 74 
                 70 
                 13588 
                  7.869498069 
                 1 
                 0.855869756 
                 56.678091 
               
               
                 15 
                 74 
                 393 
                 13588 
                  2.803383536 
                 1 
                 0.869269287 
                 60.34271545 
               
               
                 16 
                 74 
                 404 
                 13588 
                  2.727053786 
                 1 
                 0.881875859 
                 63.92395423 
               
               
                 17 
                 74 
                 14 
                 13588 
                 26.23166023 
                 1 
                 0.895305874 
                 67.64630011 
               
               
                 18 
                 74 
                 418 
                 13588 
                  2.635717057 
                 1 
                 0.888826293 
                 68.28378078 
               
               
                 19 
                 74 
                 88 
                 13588 
                  6.25982801 
                 1 
                 0.901699824 
                 71.78744367 
               
               
                 20 
                 74 
                 430 
                 13588 
                  2.562162162 
                 1 
                 0.892310062  
                 71.81242243 
               
               
                 21 
                 74 
                 431 
                 13588 
                  2.55621747 
                 1 
                 0.884669916 
                 72.09697589 
               
               
                 22 
                 74 
                 434 
                 13588 
                  2.538547764 
                 1 
                 0.881167309 
                 72.94148547 
               
               
                 23 
                 74 
                 437 
                 13588 
                  2.521120663 
                 1 
                 0.877904651 
                 73.77204657 
               
               
                 24 
                 74 
                 93 
                 13588 
                  5.923278117 
                 1 
                 0.879820716 
                 75.2555379 
               
               
                 25 
                 74 
                 315 
                 13588 
                  2.914628915 
                 1 
                 0.871223772 
                 75.28140884 
               
               
                 26 
                 74 
                 319 
                 13588 
                  2.878081844 
                 1 
                 0.872300131 
                 76.54568607 
               
               
                 27 
                 74 
                 95 
                 13588 
                  5.798577525 
                 1 
                 0.863873178 
                 76.55268842 
               
               
                 28 
                 74 
                 96 
                 13588 
                  5.738175676 
                 1 
                 0.860545996  
                 77.18216045 
               
               
                 29 
                 74 
                 19 
                 13588 
                 19.32859175 
                 1 
                 0.862220501  
                 78.38406819 
               
               
                 30 
                 74 
                 326 
                 13588 
                  2.81628254 
                 1 
                 0.856532331 
                 78.66045069 
               
               
                   
               
            
           
           
               
            
               
                 Ku KEGG pathways (a): 
               
            
           
           
               
               
               
               
               
               
            
               
                 ID 
                 Term 
                 Count 
                 % 
                 PValue 
                 minuslogP 
               
               
                   
               
               
                 1 
                 mmu04012:ErbB signaling pathway 
                 6 
                 6.060606061 
                 2.42E−05 
                 4.62 
               
               
                 2 
                 mmu04150:mTOR signaling pathway 
                 4 
                 4.04040404 
                 1.39E−03 
                 2.86 
               
               
                 3 
                 mmu05221:Acute myeloid leukemia 
                 4 
                 4.04040404 
                 1.62E−03 
                 2.79 
               
               
                 4 
                 mmu04110:Cell cycle 
                 4 
                 4.04040404 
                 0.015586032 
                 1.81 
               
               
                 5 
                 mmu04910:Insulin signaling pathway 
                 4 
                 4.04040404 
                 0.01903863 
                 1.72 
               
               
                 6 
                 mmu05213:Endometrial cancer 
                 3 
                 3.03030303 
                 0.019575313 
                 1.71 
               
               
                 7 
                 mmu04010:MARK signaling pathway 
                 5 
                 5.050505051 
                 0.022772811 
                 1.64 
               
               
                 8 
                 mmu03018:RNA degradation 
                 3 
                 3.03030303 
                 0.025605774 
                 1.59 
               
               
                 9 
                 mmu04510:Focal adhesion 
                 4 
                 4.04040404 
                 0.048078613 
                 1.32 
               
               
                 10 
                 mmu05210:Colorectal cancer 
                 3 
                 3.03030303 
                 0.049516956 
                 1.31 
               
               
                 11 
                 mmu04350:TGF-beta signaling 
                 3 
                 3.03030303 
                 0.050554685 
                 1.3 
               
               
                   
                 pathway 
                   
                   
                   
                   
               
               
                   
               
            
           
           
               
            
               
                 Ku KEGG pathways (b): 
               
            
           
           
               
               
            
               
                 ID 
                 Genes 
               
               
                   
               
               
                 1 
                 IPI00453999,IPI00125319,IPI00453603,IPI00230719,IPI00318938,IPI00668709,IPI00131999 
               
               
                 2 
                 IPI00453603,IPI00230719,IPI00318938,IPI00668709,IPI00221581 
               
               
                 3 
                 IPI00453603,IPI00230719,IPI00318938,IPI00668709,IPI00131999 
               
               
                 4 
                 IPI00125319,IPI00124717,IPI00137864,IPI00131999 
               
               
                 5 
                 IPI00125319,IPI00453603,IPI00230719,IPI00318938,IPI00668709 
               
               
                 6 
                 IPI00125319,IPI00230719,IPI00668709,IPI00131999 
               
               
                 7 
                 IPI00230719,IPI00117088,IPI00123474,IPI00668709,IPI00664670,IPI00131999 
               
               
                 8 
                 IPI00309059,IPI00119442,IPI00330066 
               
               
                 9 
                 IPI00125319,IPI00230719,IPI00405227,IPI00668709,IPI00664670 
               
               
                 10 
                 IPI00125319,IPI00230719,IPI00668709,IPI00131999 
               
               
                 11 
                 IPI00453603,IPI00137864,IPI00131999 
               
               
                   
               
            
           
           
               
            
               
                 Ku KEGG pathways (c): 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 ID 
                 List Total 
                 Pop Hits 
                 Pop Total 
                 Fold Enrichment 
                 Bonferroni 
                 Benjamini 
                 FDR 
               
               
                   
               
               
                 1 
                 25 
                 87 
                 5738 
                 15.82896552 
                 1.38E−03 
                 1.38E−03 
                  0.023962829 
               
               
                 2 
                 25 
                 54 
                 5738 
                 17.00148148 
                 0.076050732 
                 0.038777202 
                  1.366086094 
               
               
                 3 
                 25 
                 57 
                 5738 
                 16.10666667 
                 0.088400206 
                 0.030380355 
                  1.596618843 
               
               
                 4 
                 25 
                 128 
                 5738 
                  7.1725 
                 0.591555799 
                 0.200564953 
                 14.41914204 
               
               
                 5 
                 25 
                 138 
                 5738 
                  6.652753623 
                 0.6656829 
                 0.196785171 
                 17.34826426 
               
               
                 6 
                 25 
                 52 
                 5738 
                 13.24153846 
                 0.675950335 
                 0.171227632 
                 17.79538958 
               
               
                 7 
                 25 
                 265 
                 5738 
                  4.330566038 
                 0.731003969 
                 0.171037042 
                 20.41453368 
               
               
                 8 
                 25 
                 60 
                 5738 
                 11.476 
                 0.772029847 
                 0.168744085 
                 22.67212753 
               
               
                 9 
                 25 
                 198 
                 5738 
                  4.636767677 
                 0.939707705 
                 0.268063281 
                 38.63940264 
               
               
                 10 
                 25 
                 86 
                 5738 
                  8.006511628 
                 0.944686732 
                 0.251342928 
                 39.55225136 
               
               
                 11 
                 25 
                 87 
                 5738 
                  7.914482759 
                 0.948025839 
                 0.235718393 
                 40.20324697 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 11 
               
               
                   
               
               
                 Gene Symbol 
                 Annotation 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
            
               
                 Rapa replicate 1 
               
            
           
           
               
               
            
               
                 1600027N09Rik 
                 RIKEN cDNA 1600027N09 gene 
               
               
                 Ahctf1 
                 AT-hook-containing transcription factor 1 
               
               
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
               
               
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
               
               
                 Bat2l 
                 Isoform 1 of Protein BAT2-like 
               
               
                 Bclaf1 
                 Isoform 2 of Bcl-2-associated transcription factor 1 
               
               
                 Bmp2k 
                 Isoform 1 of BMP-2-inducible protein kinase 
               
               
                 C130092O11Rik 
                 Isoform 1 of Uncharacterized protein KIAA1680 
               
               
                 Carhsp1 
                 Calcium-regulated heat stable protein 1 
               
               
                 Ccn/l 
                 Isoform 1 of Cyclin-L1 
               
               
                 Chd1 
                 Chromodomain-helicase-DNA-binding protein 1 
               
               
                 Cttn 
                 Src substrate cortactin 
               
               
                 D6Wsu116e 
                 Isoform 1 of Protein FAM21 
               
               
                 Dab2 
                 Isoform p93 of Disabled homolog 2 
               
               
                 Dock11 
                 Dedicator of cytokinesis protein 11 
               
               
                 Edc4 
                 Isoform 1 of Enhancer of mRNA-decapping protein 4 
               
               
                 Eif3a 
                 Eukaryotic translation initiation factor 3 subunit A 
               
               
                 Eif4ebp1 
                 Eukaryotic translation initiation factor 4E-binding protein 1 
               
               
                 Eif4ebp2 
                 Eukaryotic translation initiation factor 4E-binding protein 2 
               
               
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation initiation factor 4 gamma 1 
               
               
                 Eif5; LOC100047658 
                 Eukaryotic translation initiation factor 5 
               
               
                 Epyc 
                 Epiphycan 
               
               
                 Fkbp15 
                 Isoform B of FK506-binding protein 15 
               
               
                 Foxk1 
                 Forkhead box protein K1 
               
               
                 Gm13697 
                 Novel protein containing MIF4G and MA3 domains 
               
               
                 Grb10 
                 Isoform 3 of Growth factor receptor-bound protein 10 
               
               
                 Gtf2f1 
                 General transcription factor IIF subunit 1 
               
               
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth factor-related protein 2 
               
               
                 Hisppd1 
                 140 kDa protein 
               
               
                 Ibtk 
                 Isoform 2 of Inhibitor of Bruton tyrosine kinase 
               
               
                 Inf2 
                 Isoform 1 of Inverted formin-2 
               
               
                 Iqsec1 
                 IQ motif and Sec7 domain 1 isoform b 
               
               
                 Irs2 
                 Insulin receptor substrate 2 
               
               
                 Iws1 
                 Isoform 1 of Protein IWS1 homolog 
               
               
                 Kdm3b 
                 Isoform 2 of Lysine-specific demethylase 3B 
               
               
                 Larp1 
                 Isoform 1 of La-related protein 1 
               
               
                 Larp4 
                 Putative uncharacterized protein 
               
               
                 Ldhd 
                 22 kDa protein 
               
               
                 Luc7l2 
                 Isoform 1 of Putative RNA-binding protein Luc7-like 2 
               
               
                 Macf1 
                 Isoform 3 of Microtubule-actin cross-linking factor 1 
               
               
                 Mett10d 
                 Isoform 1 of Putative methyltransferase METT10D 
               
               
                 Mtap1b 
                 Microtubule-associated protein 1B 
               
               
                 Myef2 
                 Isoform 2 of Myelin expression factor 2 
               
               
                 Myo5a 
                 Myosin-Va 
               
               
                 Ndrg3 
                 Protein NDRG3 
               
               
                 Nfic 
                 Isoform 1 of Nuclear factor 1 C-type 
               
               
                 Npm1 
                 Nucleophosmin 
               
               
                 Numa1 
                 Nuclear mitotic apparatus protein 1 
               
               
                 Patl1 
                 Protein PAT1 homolog 1 
               
               
                 Pcbp2 
                 Isoform 1 of Poly(rC)-binding protein 2 
               
               
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion protein PDS5 homolog B 
               
               
                 Peg3 
                 Isoform 1 of Paternally-expressed gene 3 protein 
               
               
                 Phf3 
                 PHD finger protein 3 
               
               
                 Phldb1 
                 Isoform 2 of Pleckstrin homology-like domain family B member 1 
               
               
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like domain family B member 2 
               
               
                 Pi4k2a 
                 Phosphatidylinositol 4-kinase type 2-alpha 
               
               
                 Pkn2 
                 Isoform 1 of Serine/threonine-protein kinase N2 
               
               
                 Pla2g4a 
                 Cytosolic phospholipase A2 
               
               
                 Plekhm1 
                 Pleckstrin homology domain-containing family M member 1 
               
               
                 Ppp1r12a 
                 MCG122391 isoform CRA_e 
               
               
                 Rab1 
                 Ras-related protein Rab-1A 
               
               
                 Rps6 
                 29 kDa protein 
               
               
                 Rps6kb1 
                 Isoform Alpha I of Ribosomal protein S6 kinase beta-1 
               
               
                 Rsl1d1 
                 Putative uncharacterized protein 
               
               
                 Sap30 
                 Histone deacetylase complex subunit SAP30 
               
               
                 Serbp1 
                 Isoform 1 of Plasminogen activator inhibitor 1 RNA-binding protein 
               
               
                 Sfrs8 
                 splicing factor arginine/serine-rich 8 
               
               
                 Sgta 
                 Isoform 1 of Small glutamine-rich tetratricopeptide repeat-containing protein alpha 
               
               
                 Smarca4 
                 Putative uncharacterized protein 
               
               
                 Snx17 
                 Sorting nexin-17 
               
               
                 Srpk2 
                 serine/arginine-rich protein-specific kinase 2 
               
               
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive matrix protein 2 
               
               
                 Syap1 
                 Synapse-associated protein 1 
               
               
                 Tbc1d4 
                 140 kDa protein 
               
               
                 Tcfeb 
                 Transcription factor EB 
               
               
                 Tjp2 
                 Tight junction protein ZO-2 
               
               
                 Tmem106b 
                 Transmembrane protein 106B isoform CRA_b 
               
               
                 Tmpo 
                 Isoform Beta of Lamina-associated polypeptide 2 isoforms beta/delta/epsilon/gamma 
               
               
                 Trim28 
                 Isoform 1 of Transcription intermediary factor 1-beta 
               
               
                 Ubxn7 
                 UBX domain-containing protein 7 
               
               
                 Usp24 
                 Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 24 
               
               
                 Uvrag 
                 UV radiation resistance associated 
               
               
                 Wnk1 
                 Serine/threonine-protein kinase WNK1 
               
               
                 Zc3hc1 
                 Isoform 1 of Nuclear-interacting partner of ALK 
               
               
                 Zfp516 
                 Zinc finger protein 516 
               
            
           
           
               
            
               
                 Rapa Replicate 2 
               
            
           
           
               
               
            
               
                 Mib1 
                 E3 ubiquitin-protein ligase MIB1 
               
               
                 rsp6 
                 29 kDa protein 
               
               
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive matrix protein 2 
               
               
                 Gm13099 
                 Novel protein similar to preferentially expressed antigen in melanoma-like family 
               
               
                 Rnf19b 
                 IBR domain containing 3 
               
               
                 Rps6 
                 29 kDa protein 
               
               
                 Carhsp1 
                 Calcium-regulated heat stable protein 1 
               
               
                 Pgrmc2 
                 Membrane-associated progesterone receptor component 2 
               
               
                 FLNA 
                 Filamin-A 
               
               
                 Ext1 
                 Exostosin-1 
               
               
                 Gm14085 
                 Novel protein similar to solute carrier family 28 (Sodium-coupled nucleoside 
               
               
                   
                 transporter) member 2 
               
               
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
               
               
                 Gm9757 
                 Putative uncharacterized protein 
               
               
                 Eif4ebp2 
                 Eukaryotic translation initiation factor 4E-binding protein 2 
               
               
                 Gon4l 
                 RIKEN cDNA 5830417l10 gene 
               
               
                 Mogat1 
                 2-acylglycerol O-acyltransferase 1 
               
               
                 Eef2k 
                 Elongation factor 2 kinase 
               
               
                 Dhx15 
                 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 
               
               
                 Srrm1 
                 Isoform 2 of Serine/arginine repetitive matrix protein 1 
               
               
                 Setd1a 
                 SET domain containing 1A 
               
               
                 D830015G02Rik 
                 Putative uncharacterized protein 
               
               
                 Vwa5b1 
                 von Willebrand factor A domain-containing protein 5B1 
               
               
                 Ibtk 
                 Isoform 2 of Inhibitor of Bruton tyrosine kinase 
               
               
                 Erc1; LOC100048600 
                 Isoform 1 of ELKS/RAB6-interacting/CAST family member 1 
               
               
                 Adamts2 
                 A disintegrin and metalloproteinase with thrombospondin motifs 2 
               
               
                 Grb10 
                 Isoform 3 of Growth factor receptor-bound protein 10 
               
               
                 Foxk1 
                 Forkhead box protein K1 
               
               
                 Gm6988 
                 similar to hCG1640785 
               
               
                 Tnc 
                 Isoform 1 of Tenascin 
               
               
                 Larp1 
                 Isoform 1 of La-related protein 1 
               
               
                 Alkbh6 
                 24 kDa protein 
               
               
                 Larp7 
                 Isoform 1 of La-related protein 7 
               
               
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
               
               
                 Qsox2 
                 Isoform 3 of Sulfhydryl oxidase 2 
               
               
                 Wnk1 
                 Serine/threonine-protein kinase WNK1 
               
               
                 Megf11 
                 Isoform 4 of Multiple epidermal growth factor-like domains 11 
               
               
                 Ahctf1 
                 AT-hook-containing transcription factor 1 
               
               
                 Fxr1 
                 Isoform E of Fragile X mental retardation syndrome-related protein 1 
               
               
                 Ddx21 
                 Nucleolar RNA helicase 2 
               
               
                 Lin9 
                 Isoform 2 of Lin-9 homolog 
               
               
                 D6Wsu116e 
                 Isoform 1 of Protein FAM21 
               
               
                 Sfrs8 
                 splicing factor arginine/serine-rich 8 
               
               
                 Ppfibp2 
                 Isoform 4 of Liprin-beta-2 
               
               
                 Hdgfrp2 
                 Isoform 3 of Hepatoma-derived growth factor-related protein 2 
               
               
                 Irs2 
                 Insulin receptor substrate 2 
               
               
                 Tinf2 
                 Putative uncharacterized protein 
               
               
                 Hisppd1 
                 140 kDa protein 
               
               
                 Edc3 
                 Enhancer of mRNA-decapping protein 3 
               
               
                 Aim1l 
                 Absent in melanoma 1-like 
               
               
                 Herc1 
                 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 
               
               
                   
                 (CHC1)-like domain (RLD) 1 
               
               
                 Fbxw9 
                 F-box and WD-40 domain protein 9 
               
               
                 Sfrs18 
                 splicing factor arginine/serine-rich 18 
               
               
                 Dnajc2 
                 DnaJ homolog subfamily C member 2 
               
               
                 Cux1 
                 cut-like homeobox 1 isoform a 
               
               
                 Ranbp10 
                 Ran-binding protein 10 
               
               
                 Foxk2 
                 Isoform 1 of Forkhead box protein K2 
               
               
                 Bod1l 
                 biorientation of chromosomes in cell division 1-like 
               
               
                 Zeb2 
                 Zinc finger E-box-binding homeobox 2 
               
               
                 Bcr 
                 Breakpoint cluster region protein 
               
               
                 Pdcd11 
                 Protein RRP5 homolog 
               
               
                 Hn1l 
                 Hematological and neurological expressed 1-like protein 
               
               
                 Palm 
                 Isoform 1 of Paralemmin 
               
               
                 Phf3 
                 PHD finger protein 3 
               
               
                 Ptk2 
                 Isoform 1 of Focal adhesion kinase 1 
               
               
                 1110013L07Rik 
                 Putative uncharacterized protein 
               
               
                 Tcfeb 
                 Transcription factor EB 
               
               
                 Ehmt2 
                 Isoform 1 of Histone-lysine N-methyltransferase H3 lysine-9 specific 3 
               
               
                 Zc3h4 
                 Isoform 2 of Zinc finger CCCH domain-containing protein 4 
               
               
                 Ktn1 
                 Isoform 1 of Kinectin 
               
               
                 Pbx2 
                 Pre-B-cell leukemia transcription factor 2 
               
               
                 Phldb1 
                 Isoform 2 of Pleckstrin homology-like domain family B member 1 
               
               
                 Cdgap 
                 Cdc42 GTPase-activating protein 
               
               
                 Eif3a 
                 Eukaryotic translation initiation factor 3 subunit A 
               
               
                 Tbc1d4 
                 140 kDa protein 
               
               
                 Dennd4a 
                 hypothetical protein LOC102442 
               
               
                 Wdr91 
                 WD repeat-containing protein 91 
               
               
                 Junb 
                 Transcription factor jun-B 
               
               
                 Srpk2 
                 serine/arginine-rich protein-specific kinase 2 
               
               
                 Eif4b 
                 Eukaryotic translation initiation factor 4B 
               
               
                 Gbf1 
                 Golgi-specific brefeldin A-resistance factor 1 
               
               
                 Cd2ap 
                 CD2-associated protein 
               
               
                 LOC100048559; Sfrs1 
                 Isoform 1 of Splicing factor arginine/serine-rich 1 
               
               
                 Ccdc6 
                 coiled-coil domain containing 6 
               
               
                 Ndrg3 
                 Protein NDRG3 
               
               
                 Ulk1 
                 Putative uncharacterized protein 
               
               
                 Arhgap17 
                 Isoform 1 of Rho GTPase-activating protein 17 
               
               
                 Spna2 
                 Isoform 2 of Spectrin alpha chain brain 
               
               
                 Patl1 
                 Protein PAT1 homolog 1 
               
               
                 Bcas3 
                 Isoform 1 of Breast carcinoma-amplified sequence 3 homolog 
               
               
                 Atg2a 
                 Autophagy-related protein 2 homolog A 
               
               
                 Ccnl1 
                 Isoform 1 of Cyclin-L1 
               
               
                 Znrf2 
                 E3 ubiquitin-protein ligase ZNRF2 
               
               
                 Larp4 
                 Putative uncharacterized protein 
               
               
                 Mtor 
                 Isoform 1 of FKBP12-rapamycin complex-associated protein 
               
               
                 Gsk3b 
                 Glycogen synthase kinase-3 beta 
               
               
                 Ranbp9 
                 RAN binding protein 9 
               
               
                 Kdm6a 
                 Isoform 1 of Lysine-specific demethylase 6A 
               
               
                 C130092O11Rik 
                 Isoform 1 of Uncharacterized protein KIAA1680 
               
               
                 Mtap1b 
                 Microtubule-associated protein 1B 
               
               
                 Prkd2 
                 Serine/threonine-protein kinase D2 
               
               
                 Usp36 
                 Ubiquitin specific peptidase 36 
               
               
                 Slc4a1ap 
                 solute carrier family 4 (anion exchanger) member 1 adaptor protein 
               
               
                 Llgl1 
                 lethal giant larvae homolog 1 isoform 1 
               
               
                 Cabin1 
                 calcineurin binding protein 1 
               
               
                 Pcbp1 
                 Poly(rC)-binding protein 1 
               
               
                 Eif4ebp1 
                 Eukaryotic translation initiation factor 4E-binding protein 1 
               
               
                 Rfc1 
                 Rfc1 protein 
               
               
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion protein PDS5 homolog B 
               
               
                 St5 
                 Isoform 1 of Suppression of tumorigenicity 5 
               
               
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation initiation factor 4 gamma 1 
               
               
                 Pom121 
                 Nuclear envelope pore membrane protein POM 121 
               
               
                 Smarcc2 
                 Isoform 2 of SWI/SNF complex subunit SMARCC2 
               
               
                 Eps8l2 
                 Isoform 1 of Epidermal growth factor receptor kinase substrate 8-like protein 2 
               
               
                 Plekhm1 
                 Pleckstrin homology domain-containing family M member 1 
               
               
                 B230208H17Rik 
                 Putative GTP-binding protein Parf 
               
               
                 Mll2 
                 similar to myeloid/lymphoid or mixed-lineage leukemia 2 
               
               
                 Snx30 
                 Sorting nexin-30 
               
               
                 Rps6kb1 
                 Isoform Alpha I of Ribosomal protein S6 kinase beta-1 
               
               
                 Usp24 
                 Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 24 
               
               
                 Micall1 
                 Isoform 1 of MICAL-like protein 1 
               
               
                 Med1 
                 Isoform 4 of Mediator of RNA polymerase II transcription subunit 1 
               
               
                 Sorbs3 
                 Vinexin 
               
               
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like domain family B member 2 
               
               
                 Smarcad1 
                 Isoform 1 of SWI/SNF-related matrix-associated actin-dependent regulator of 
               
               
                   
                 chromatin subfamily A containing DEAD/H box 1 
               
               
                 Crkrs 
                 Isoform 2 of Cell division cycle 2-related protein kinase 7 
               
               
                 Gtf2f1 
                 General transcription factor IIF subunit 1 
               
               
                 Scrib 
                 Isoform 1 of Protein LAP4 
               
               
                 2610110G12Rik 
                 Isoform 1 of UPF0635 protein C6orf134 homolog 
               
               
                 Mllt4 
                 Isoform 3 of Afadin 
               
               
                 Nacc1 
                 Nucleus accumbens-associated protein 1 
               
               
                 Zfp106 
                 Isoform 1 of Zinc finger protein 106 
               
               
                 Rictor 
                 Isoform 1 of Rapamycin-insensitive companion of mTOR 
               
               
                 Tns1 
                 tensin 1 
               
               
                 Cttn 
                 Src substrate cortactin 
               
               
                 Sbno1 
                 Isoform 2 of Protein strawberry notch homolog 1 
               
               
                 Fmnl3 
                 Isoform 1 of Formin-like protein 3 
               
               
                 Syap1 
                 Synapse-associated protein 1 
               
               
                 Strn3 
                 Striatin-3 
               
               
                 Rb1 
                 Retinoblastoma-associated protein 
               
               
                 Ehbp1 
                 Isoform 2 of EH domain-binding protein 1 
               
               
                 Sqstm1 
                 Isoform 1 of Sequestosome-1 
               
               
                 Zc3hc1 
                 Isoform 1 of Nuclear-interacting partner of ALK 
               
               
                 Tox4 
                 TOX high mobility group box family member 4 
               
               
                 Emg1 
                 Probable ribosome biogenesis protein NEP1 
               
               
                 Pcm1 
                 Isoform 1 of Pericentriolar material 1 protein 
               
               
                 Trip10 
                 Isoform 3 of Cdc42-interacting protein 4 
               
               
                 LOC100048123; Akt2 
                 RAC-beta serine/threonine-protein kinase 
               
               
                 Aak1 
                 Isoform 2 of AP2-associated protein kinase 1 
               
               
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive matrix protein 2 
               
               
                 Phldb2 
                 Isoform 1 of Pleckstrin homology-like domain family B member 2 
               
               
                 Phldb1 
                 Isoform 2 of Pleckstrin homology-like domain family B member 1 
               
               
                 Ahctf1 
                 AT-hook-containing transcription factor 1 
               
               
                 Ahctf1 
                 AT-hook-containing transcription factor 1 
               
               
                 Ahctf1 
                 AT-hook-containing transcription factor 1 
               
               
                 Arhgap17 
                 Isoform 1 of Rho GTPase-activating protein 17 
               
               
                 Rb1 
                 Retinoblastoma-associated protein 
               
               
                 Rb1 
                 Retinoblastoma-associated protein 
               
               
                 Tox4 
                 TOX high mobility group box family member 4 
               
               
                 Tox4 
                 TOX high mobility group box family member 4 
               
               
                 Hells 
                 Isoform 1 of Lymphocyte-specific helicase 
               
               
                 Hells 
                 Isoform 1 of Lymphocyte-specific helicase 
               
               
                 Hells 
                 Isoform 1 of Lymphocyte-specific helicase 
               
               
                 Erbb2ip 
                 Isoform 1 of Protein LAP2 
               
               
                 Eif4ebp2 
                 Eukaryotic translation initiation factor 4E-binding protein 2 
               
               
                 Eif4ebp2 
                 Eukaryotic translation initiation factor 4E-binding protein 2 
               
               
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion protein PDS5 homolog B 
               
               
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion protein PDS5 homolog B 
               
               
                 Pds5b 
                 Isoform 1 of Sister chromatid cohesion protein PDS5 homolog B 
               
               
                 Fam129a 
                 Protein Niban 
               
               
                 Eif4ebp1 
                 Eukaryotic translation initiation factor 4E-binding protein 1 
               
               
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
               
               
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
               
               
                 Ahnak 
                 AHNAK nucleoprotein isoform 1 
               
               
                 Eif4ebp1 
                 Eukaryotic translation initiation factor 4E-binding protein 1 
               
               
                 Arid1a 
                 AT rich interactive domain 1A 
               
               
                 Fam129a 
                 Protein Niban 
               
               
                 Fam129a 
                 Protein Niban 
               
               
                 Atxn2 
                 ataxin 2 
               
               
                 Atxn2 
                 ataxin 2 
               
               
                 Ranbp10 
                 Ran-binding protein 10 
               
               
                 Ranbp10 
                 Ran-binding protein 10 
               
               
                 Ranbp10 
                 Ran-binding protein 10 
               
               
                 Ranbp10 
                 Ran-binding protein 10 
               
               
                 Ranbp10 
                 Ran-binding protein 10 
               
               
                 Tox4 
                 TOX high mobility group box family member 4 
               
               
                 Tox4 
                 TOX high mobility group box family member 4 
               
            
           
           
               
            
               
                 Ku 
               
            
           
           
               
               
            
               
                 Myo18a 
                 Isoform 4 of Myosin-XVIIIa 
               
               
                 Brd2 
                 Isoform 2 of Bromodomain-containing protein 2 
               
               
                 6330577E15Rik 
                 Uncharacterized protein C10orf78 homolog 
               
               
                 Best3 
                 Bestrophin-3 
               
               
                 Larp1 
                 Isoform 1 of La-related protein 1 
               
               
                 Fam62c 
                 Isoform 1 of Extended synaptotagmin-3 
               
               
                 Mdn1 
                 Midasin homolog 
               
               
                 Rtn4 
                 Isoform 2 of Reticulon-4 
               
               
                 Pcdh24 
                 Pcdh24 protein 
               
               
                 Synj1 
                 similar to mKIAA0910 protein 
               
               
                 Zfp318 
                 zinc finger protein 318 isoform 1 
               
               
                 Akt1s1 
                 Proline-rich AKT1 substrate 1 
               
               
                 Alpk3 
                 myocyte induction differentiation originator 
               
               
                 Zc3h14 
                 Isoform 2 of Zinc finger CCCH domain-containing protein 14 
               
               
                 Edc4 
                 Isoform 1 of Enhancer of mRNA-decapping protein 4 
               
               
                 Srrm2 
                 Isoform 3 of Serine/arginine repetitive matrix protein 2 
               
               
                 Kif20b 
                 Isoform 1 of M-phase phosphoprotein 1 
               
               
                 1110007A13Rik 
                 UPF0557 protein C10orf119 homolog 
               
               
                 Pi4k2a 
                 Phosphatidylinositol 4-kinase type 2-alpha 
               
               
                 Top2b 
                 DNA topoisomerase 2-beta 
               
               
                 BC021381 
                 Isoform 2 of Uncharacterized protein KIAA1931 
               
               
                 Bbx 
                 Isoform 1 of HMG box transcription factor BBX 
               
               
                 Vcl 
                 Vinculin 
               
               
                 Eif4ebp1 
                 Eukaryotic translation initiation factor 4E-binding protein 1 
               
               
                 Rrp15 
                 RRP15-like protein 
               
               
                 D10Wsu102e 
                 Uncharacterized protein C12orf45 homolog 
               
               
                 Braf 
                 Isoform 1 of B-Raf proto-oncogene serine/threonine-protein kinase 
               
               
                 Atg2b 
                 Isoform 1 of Autophagy-related protein 2 homolog B 
               
               
                 Npm1 
                 Nucleophosmin 
               
               
                 Pcsk5 
                 proprotein convertase subtilisin/kexin type 5 
               
               
                 Mtap1b 
                 Microtubule-associated protein 1B 
               
               
                 Ercc6l 
                 DNA excision repair protein ERCC-6-like 
               
               
                 Serinc1 
                 Serine incorporator 1 
               
               
                 Klf3; LOC100046855 
                 Krueppel-like factor 3 
               
               
                 Smarca4 
                 Putative uncharacterized protein 
               
               
                 Aak1 
                 Uncharacterized protein FLJ45252 homolog 
               
               
                 Eif4ebp2 
                 Eukaryotic translation initiation factor 4E-binding protein 2 
               
               
                 Ndrg1 
                 Protein NDRG1 
               
               
                 Melk 
                 Maternal embryonic leucine zipper kinase 
               
               
                 Arhgef17 
                 Isoform 1 of Rho guanine nucleotide exchange factor 17 
               
               
                 Grit 
                 Isoform 2 of Rho/Cdc42/Rac GTPase-activating protein RICS 
               
               
                 Mdc1 
                 mediator of DNA damage checkpoint 1 
               
               
                 Nfkb2 
                 NF-kB2 splice variant 4 
               
               
                 Pcm1 
                 Isoform 1 of Pericentriolar material 1 protein 
               
               
                 Mybbp1a 
                 Myb-binding protein 1A 
               
               
                 Sf3b1 
                 Splicing factor 3B subunit 1 
               
               
                 Atrx 
                 Transcriptional regulator ATRX 
               
               
                 Ccdc88a 
                 Isoform 2 of Girdin 
               
               
                 Baz1b 
                 Isoform 1 of Tyrosine-protein kinase BAZ1B 
               
               
                 Nedd4l 
                 Isoform 3 of E3 ubiquitin-protein ligase NEDD4-like 
               
               
                 Orc6l 
                 Origin recognition complex subunit 6 
               
               
                 Trp53bp1 
                 Transformation related protein 53 binding protein 1 
               
               
                 Map3k2 
                 Mitogen-activated protein kinase kinase kinase 2 
               
               
                 Hectd2 
                 Hectd2 protein 
               
               
                 Usp10 
                 Ubiquitin carboxyl-terminal hydrolase 10 
               
               
                 D830031N03Rik 
                 similar to mKIAA0754 protein 
               
               
                 Nck1 
                 non-catalytic region of tyrosine kinase adaptor protein 1 
               
               
                 Exosc9 
                 Exosome complex exonuclease RRP45 
               
               
                 Dap 
                 Death-associated protein 1 
               
               
                 Rps6kb1 
                 Isoform Alpha I of Ribosomal protein S6 kinase beta-1 
               
               
                 Lmna 
                 Isoform C2 of Lamin-A/C 
               
               
                 Sltm 
                 Isoform 1 of SAFB-like transcription modulator 
               
               
                 Sh3pxd2a 
                 Isoform 1 of SH3 and PX domain-containing protein 2A 
               
               
                 Flnc 
                 Isoform 1 of Filamin-C 
               
               
                 Oxr1 
                 Isoform 2 of Oxidation resistance protein 1 
               
               
                 Rin2 
                 Isoform 1 of Ras and Rab interactor 2 
               
               
                 Nek9 
                 Serine/threonine-protein kinase Nek9 
               
               
                 Pebp1 
                 Phosphatidylethanolamine-binding protein 1 
               
               
                 Pop1 
                 Processing of 1 ribonuclease P/MRP family 
               
               
                 Serhl 
                 Serine hydrolase-like protein 
               
               
                 Epb4.1l3 
                 Isoform 1 of Band 4.1-like protein 3 
               
               
                 Hnrpll 
                 Isoform 1 of Heterogeneous nuclear ribonucleoprotein L-like 
               
               
                 Samhd1 
                 SAM domain and HD domain-containing protein 1 
               
               
                 Zfp828 
                 Zinc finger protein 828 
               
               
                 Larp7 
                 Isoform 1 of La-related protein 7 
               
               
                 Myc 
                 myc proto-oncogene protein 
               
               
                 Myo9a 
                 Isoform 2 of Myosin-IXa 
               
               
                 Gsk3b 
                 Glycogen synthase kinase-3 beta 
               
               
                 Zfp395 
                 zinc finger protein 395 
               
               
                 Bend3 
                 BEN domain-containing protein 3 
               
               
                 Akap12 
                 Isoform 1 of A-kinase anchor protein 12 
               
               
                 Eif4g1 
                 Isoform 1 of Eukaryotic translation initiation factor 4 gamma 1 
               
               
                 Eif4b 
                 Eukaryotic translation initiation factor 4B 
               
               
                 Dock7 
                 Isoform 2 of Dedicator of cytokinesis protein 7 
               
               
                 Patl1 
                 Protein PAT1 homolog 1 
               
               
                 Slc7a11 
                 Cystine/glutamate transporter 
               
               
                 Myo9b 
                 Isoform 1 of Myosin-IXb 
               
               
                 Setd2 
                 SET domain containing 2 
               
               
                 Gphn 
                 Gephyrin 
               
               
                 Erf 
                 ETS domain-containing transcription factor ERF 
               
               
                 Spnb2 
                 Isoform 2 of Spectrin beta chain brain 1 
               
               
                 Phip 
                 PH-interacting protein 
               
               
                 Sdpr 
                 Serum deprivation-response protein 
               
               
                 Tcof1 
                 Treacle protein 
               
               
                 Pwp1 
                 Periodic tryptophan protein 1 homolog 
               
               
                 Rb/1 
                 Isoform Long of Retinoblastoma-like protein 1 
               
               
                 Eef1b2 
                 Elongation factor 1-beta 
               
               
                 Phactr4 
                 Isoform 1 of Phosphatase and actin regulator 4 
               
               
                 C230081A13Rik 
                 Tyrosine-protein kinase-protein kinase SgK269 
               
               
                 Ahnak2 
                 Putative uncharacterized protein 
               
               
                   
               
               
                 Table 11. Proteins with downregulated phosphorylation identified in the rapamycin and Ku-0063794 screen.