Patent Publication Number: US-2017368062-A1

Title: Pharmaceutical composition including pimobendan

Description:
CROSS REFERENCE TO RELATED APPLICATIONS 
     The present application is a continuation of U.S. Nonprovisional application Ser. No. 14/465,273, filed 21 Aug. 2014 and entitled “Pharmaceutical Composition Including Pimobendan”, which is a continuation of U.S. Nonprovisional application Ser. No. 13/802,989, filed 14 Mar. 2013 and entitled “Packaging Assembly for Pharmaceutical Composition Including Pimobendan,” which is a continuation of U.S. Nonprovisional application Ser. No. 13/402,292, filed 22 Feb. 2012 and entitled “Pharmaceutical Composition Comprising Pimobendan,” which is a divisional of U.S. Nonprovisional application Ser. No. 11/072,207, filed 4 Mar. 2005 and entitled “Pharmaceutical Composition Comprising Pimobendan,” which claims priority to German Patent Application No. 102004011512, filed on 8 Mar. 2004. The disclosure of each aforementioned application is incorporated herein by reference in its entirety. 
    
    
     FIELD OF THE INVENTION 
     The invention relates to the field of animal health. In particular, the invention relates to novel oral pharmaceutical compositions comprising, as part of the pharmaceutically active compounds, pimobendan. 
     BACKGROUND OF THE INVENTION 
     Pimobendan, (4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazone) is disclosed in U.S. Pat. No. 4,361,563, herein incorporated by reference in its entirety. Pimobendan is a cardiotonic, hypotensive and anti-thrombotic. Said substance is useful in the treatment of congestive heart failure. 
     Pimobendan hardly dissolves in water. The resorption of pimobendan when administered orally is prone to considerable inter- and intra-individual fluctuations if the active substance is incorporated in known or conventional pharmaceutical forms for oral administration. The reason for this is that pimobendan is characterized by a low solubility in aqueous media and a very highly pH-dependent solubility. To overcome this, hard gelatine capsules were used containing pimobendan formulated with citric acid, in particular at a weight ratio of pimobendan to citric acid of between 1:10 and 1:20 (U.S. Pat. No. 5,364,646, herein incorporated by reference in its entirety). However, the high quantity of citric acid and the acidic taste of citric acid is not readily accepted by most animals—thus, such capsules have to be force-fed to the animals or mixed with food prior to application. 
     The problem underlying the present invention was to provide a pimobendan solid formulation readily acceptable by mammalian subjects, especially small animals. 
     SUMMARY OF THE INVENTION 
     The invention relates to novel solid formulations comprising as a pharmaceutically active compound pimobendan or a pharmaceutically acceptable salt thereof which is homogenously dispersed in a polyvalent acid and a flavor acceptable to small animals. Preferably, such solid formulations are granules or tablets. Most preferred is a tablet characterized in that the tablet comprises, 1.25 mg, 2.5 mg, 5 mg or 10 mg pimobendan, and further comprises lactose, corn starch, croscarmellose-sodium, citric acid, preferably at an amount of 50 mg/g of the solid formulation, artificial beef flavor, polyvidone, colloidal anhydrous silica and magnesium stearate. 
     The invention further relates to fluid-bed granulation processes for production of the solid formulations comprising the following steps:
         a) an aqueous solution of pimobendan and a binder as defined above is sprayed onto a solid carrier bed comprising one or more carriers and/or excipients, flavor and citric acid anhydride and   b) the resulting mixture is dried and   c) the dried mixture is sieved and de-agglomerated and   d) a flow regulator is added to the sieved and de-agglomerated mixture and   e) a lubricant is added to the resulting mixture and   f) the resulting mixture with lubricant is blended for uniformity of granules to obtain final granules and/or   g) the final granules are compressed to solid formulations.       

     Step g) is omitted if the solid formulation is a granule. If the solid formulation is a tablet, step g) is carried out. 
     Furthermore, the invention relates to a method of prevention and/or treatment of diseases wherein cardiotonic, hypotensive and anti-thrombotic substances have a therapeutic benefit, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a solid formulation prepared as described above. 
     Preferred is a method of prevention and/or treatment of congestive heart failure, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a solid formulation according to the invention as disclosed above. Most preferably, the method comprises administering a tablet according to the invention, as defined above. 
     Furthermore, the invention relates to a method for manufacturing a medicament for the prevention and/or treatment of congestive heart failure, Additionally, the invention relates to a method for manufacturing a medicament for the prevention and/or treatment of congestive heart failure, characterized in that a tablet comprising 1.25 mg, 2.5 mg, 5 mg or 10 mg pimobendan and further comprising lactose, corn starch, croscarmellose-sodium, 50 mg/g citric acid, artificial beef flavor, polyvidone, colloidal anhydrous silica and magnesium stearate is made. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1 : Illustration of the basic top spray fluid bed process. Reference signs:  1  Exhaust air ventilator;  2  Filter;  3  Pump;  4  Stirrer;  5  Aqueous Suspension of micronized pimobendan and binder solution (PVP, HPMC, starch, gelatin);  6  Heating device for inlet air;  7  Sieve;  8  Nozzle, aqueous suspension is sprayed onto powder bed (citric acid, lactose, starch, flavor);  9  Powder bed. 
         FIG. 2 : Flow Chart of Manufacturing Process. 
         FIG. 3 : Dissolution Profiles, Pimobendan 1.25 mg tablets, showing 95% confidence intervals of the mean; USP apparatus  2  (Paddle), Rotation Speed 75 rpm, Buffer pH 4.0. Comparison of dissolution profiles of tablets which were stored 1 and 6 months at 40° C./75% in HDPE bottles; batch no. PB020049. 
         FIG. 4 : Dissolution Profiles, Pimobendan 1.25 mg tablets, showing 95% confidence intervals of the mean; USP apparatus  2  (Paddle), Rotation Speed 75 rpm, Buffer pH 4.0. Comparison of dissolution profiles of tablets which were stored 12 days at 25° C./60% in open glass bottles; batch no. PB010080. 
         FIG. 5 : Dissolution Profiles, Pimobendan 2.5 mg tablets, showing 95% confidence intervals of the mean; USP apparatus  2  (Paddle), Rotation Speed 75 rpm, Buffer pH 4.0. Comparison of dissolution profiles of tablets which were stored 3 and 6 months at 40.degree. C./75% in Alu-Alu Blister; batch no. PB010076 
         FIG. 6 : Dissolution Profiles, Pimobendan 5.0 mg tablets, showing 95% confidence intervals of the mean; USP apparatus  2  (Paddle), Rotation Speed 75 rpm, Buffer pH 4.0. Comparison of dissolution profiles of tablets which were stored 6 months at 40° C./75% in HDPE bottles; batch no. PB020059. 
         FIG. 7 : Dissolution Profiles, Pimobendan 5.0 mg tablets, showing 95% confidence intervals of the mean; USP apparatus 2 (Paddle), Rotation Speed 75 rpm, Buffer pH 4.0. Manufacturing variable: Different compression forces; batch no. PB020205. 
     
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     Before the embodiments of the present invention it must be noted that as used herein and in the appended claims, the singular forms “a”, “an”, and “the” include plural reference unless the context clearly dictates otherwise. Thus, for example, reference to “a tablet” includes a plurality of such tablets, reference to the “carrier” is a reference to one or more carriers and equivalents thereof known to those skilled in the art, and so forth. Unless defined otherwise, all technical and scientific terms used herein have the same meanings as commonly understood by one of ordinary skill in the art to which this invention belongs. All given ranges and values may vary by 1 to 5% unless indicated otherwise or known otherwise by the person skilled in the art. Accordingly, the term “about” is not used in the description. 
     Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods, devices, and materials are described. All publications mentioned herein are incorporated herein by reference for the purpose of describing and disclosing the substances, excipients, carriers, and methodologies as reported in the publications which might be used in connection with the invention. Nothing herein is to be construed as an admission that the invention is not entitled to antedate such disclosure by virtue of prior invention. 
     The solution to the above technical problem is achieved by the description and the embodiments characterized in the claims. 
     To overcome the difficulties in the art, a process was invented. Only the invention of this novel, fluid-bed granulation process allowed the formulation of solid formulations according to the invention. With the process according to the invention, it was possible to formulate a long-term stable, capable of being produced on a large scale, homogenously dispersed, fast-releasing solid formulation. Despite the large size, pimobendan was homogenously dispersed. Such solid formulations comprise a flavor suitable for small animals, which surprisingly still allows a formulation having a polyvalent acid and yet have a palatibility rate of more than 70%—in many cases more than 90%. Thus, the solid formulations according to the invention are a major step forward in therapeutic application as they do not have to be force-fed to the animal. 
     In a first important embodiment, the invention relates to a solid formulation, comprising pimobendan or a pharmaceutically acceptable salt thereof, see e.g. U.S. Pat. No. 4,361,563 or U.S. Pat. No. 5,364,646 (both herein incorporated by reference in its entirety), which is homogenously dispersed in a polyvalent acid selected from the group consisting of citric acid, acetic acid, maleic acid, tartaric acid and the anhydride of any of said polyvalent acids and mixtures thereof, and a flavor acceptable to small animals. Such flavors according to the invention preferably are selected from artificial beef flavors, artificial chicken flavors, pork liver extract, artificial meat flavor, honey flavor and the like. Said flavors not only disguise the taste of the polyvalent acid, but also the taste of pimobendan. 
     Preferably, the solid formulation according to the invention is a tablet or granule formulation. The granule formulation according to the invention is explained in more detail below. More preferably, the solid formulation is chewable. 
     The invention preferably also relates to a solid formulation according to the invention, further comprising one or several pharmaceutically acceptable excipients. Excipients according to the invention are preferably selected from the group consisting of diluents, disintegrants, carriers, binders, flow regulators, lubricants and solvents. Any other excipients known to the skilled person and found suitable for the solid formulation according to the invention may also be comprised in the solid formulation according to the invention. See also Remington, J. P. The science and Practice of Pharmacy (2000). 20th ed. Lippincott Williams &amp; Wilkins Publishers, Philadelphia, US. More preferably, said excipients are carriers/disintegrants selected from the group lactose, starch, cellulose, microcrystalline cellulose and cellulose derivatives, e.g. methylcellulose, and the like. Any other carrier known to the skilled person and found suitable for the solid formulation according to the invention may also form part of the solid formulation according to the invention. See also Remington, J. P. The science and Practice of Pharmacy (2000). 20th ed. Lippincott Williams &amp; Wilkins Publishers, Philadelphia, US. 
     One or several binders according to the invention are preferably selected from the group consisting of polyvidone (used synonymously for povidone), methylcellulose, hydroxypropylmethylcellulose (HPMC), hydroxymethylcellulose, starch, gelatin, and the like. Any other binder known to the skilled person and found suitable for the solid formulation according to the invention may also be comprised in the solid formulation according to the invention. See also Remington, J. P. The science and Practice of Pharmacy (loc. cit.). 
     The solid formulation according to the invention may also comprise one or several flow regulators selected from the group consisting of silica, preferably colloidal anhydrous silica, calcium silicate, magnesium silicate, talc, and the like. Any other flow regulator known to the skilled person and found suitable for the solid formulation according to the invention may also be incorporated into the solid formulation according to the invention. See also Remington, J. P. The science and Practice of Pharmacy (loc. cit.). 
     The solid formulation according to the invention may also comprise one or several disintegrants selected from the group consisting of croscarmellose sodium, sodium starch glycolate, pregelatinised starch, cross-linked polyvinylpyrrolidone and the like. Any other disintegrant known to the skilled person and found suitable for the solid formulation according to the invention may also form part of the solid formulation according to the invention. See also Remington, J. P. The science and Practice of Pharmacy (loc. cit.). 
     The solid formulation according to the invention may also comprise one or several lubricants selected from the group consisting of magnesium stearate, calcium stearate, glyceryl behenate, polyethylene glycol, stearic acid, talc and the like. Any other lubricant known to the skilled person and found suitable for the solid formulation according to the invention may form part of the solid formulation according to the invention. See also Remington, J. P. The science and Practice of Pharmacy (loc. cit.). 
     The invention preferably also relates to a solid formulation according to the invention, characterized in that the carriers are starch and lactose. The invention preferably also relates to a solid formulation according to the invention, characterized in that the lactose consists of coarse particles greater than 200 μm in size. The person skilled in the art knows other types of lactose which are suitable as well as carrier according to the invention, e.g. fine lactose equal or smaller than 200 μm in size or spray-dried lactose. Preferred is lactose consisting of coarse particles greater than 200 μm in size. 
     The invention preferably also relates to a solid formulation according to the invention, characterized in that the starch or various starches are selected from the group consisting of native starch, gelatinized starch, partly gelatinized starch, starch powder, starch granules, chemically modified starch and swellable, physically modified starch. 
     The invention preferably also relates to a solid formulation according to the invention, characterized in that the starch is corn starch. 
     The invention preferably also relates to a solid formulation according to the invention, comprising 0.5 mg to 20 mg of pimobendan. The more preferred solid formulation contains 1 to 10 mg of pimobendan. The even more preferred solid formulation contains 1.25 to 5 mg of pimobendan. Most preferred solid formulations contain 1.25 mg, 2.5 mg, 5 mg or 10 mg of pimobendan. 
     The invention preferably also relates to a solid formulation according to the invention, comprising a content of 1:10-1:40 of pimobendan in relation to citric acid anhydride. The preferred ratio is 1:20. 
     The invention preferably also relates to a solid formulation according to the invention, characterized in that the weight of the whole solid formulation is in the range of 250 to 3000 mg, with a more preferred weight range of 500 mg to 2000 mg, and most preferred weight of 500 mg, 1000 mg or 2000 mg. 
     The invention preferably also relates to a solid formulation according to the invention, characterized in that the solid formulation is produced by a fluid-bed granulation process comprising or consisting of the steps:
         a) an aqueous solution of pimobendan and a binder as defined above is sprayed onto a solid carrier bed comprising one or several carriers and/or excipients as defined above, flavor and citric acid anhydride and   b) the mixture of a) is dried and   c) the mixture of b) is sieved and de-agglomerated and   d) a flow regulator is added to the mixture of c) and   e) a lubricant is added to the mixture of d) and   f) the mixture of e) is blended for uniformity of granules to obtain final granules and/or   g) the final granules of f) are compressed to solid formulations.       

     Step g) is omitted if the solid formulation is a granule. If the solid formulation is a tablet, step g) is carried out. 
     The invention preferably also relates to a solid formulation according to the invention, characterized in that the solid formulation is produced by a fluid-bed granulation process comprising or consisting of the steps:
         a) an aqueous solution of pimobendan and povidone is sprayed onto a solid carrier bed comprising lactose, starch, flavor and citric acid anhydride and   b) the mixture of a) is dried and   c) the mixture of b) is sieved and de-agglomerated and   d) a flow regulator is added to the mixture of c) and   e) a lubricant is added to the mixture of d) and   f) the mixture of e) is blended for uniformity of granules to obtain final granules and/or   g) the final granules of f) are compressed to solid formulations.       

     Step g) is omitted if the solid formulation is a granule. If the solid formulation is a tablet, step g) is carried out. 
     The invention preferably relates to a granule formulation as obtained by the process above that can either be administered in the granular form or as tablets after compressing the final granules to tablets. Therefore, the solid formulation according to the invention preferably is a granule (or a plurality of such granules) or a tablet. The administration of the granules can take place by mixing with food or by offering the granules directly to the animal, e.g. in a bowl. The application of the granular form will allow an individual dosing of pimobendan according to the body weight of the animal. 
     The tablets according to the invention have surprising advantages. The dissolution profile ensures immediate release of pimobendan. Surprisingly, it could be demonstrated that while compressing the final granules as mentioned above, a decrease in the dissolution characteristics is not observed. By ensuring an immediate release profile of pimobendan, the amount of drug to be administered can be kept as low as possible, thereby improving the safety profile, which is especially important for long-term treatment. 
     Furthermore, the dosing accuracy of the tablet is excellent. This is due to the fact that in accordance with the manufacturing process according to this invention, an excellent uniformity of pimobendan content is achieved. Furthermore, the tablets can be broken into two halves so that half the dose per tablet can be administered. Compared with the existing gelatin capsule, the dosing accuracy and compliance of both the animal and the animal owner are assured. This is even more important since the drug is administered for a chronic condition and long-term treatment. 
     Also, the palatability of the tablet is excellent. More than 90% of the dogs to whom the tablet according to this invention was given accepted the tablet voluntarily with only the tablet offered in a bowl. Compared with the existing gelatin capsule, the ease of administration has increased compliance with the prescribed treatment regime. This is important since the drug is administered for a chronic condition. 
     The invention preferably also relates to a tablet according to the invention, characterized in that the tablet is stable for at least 18 months at 25.degree. C. and 60% relative humidity. In the examples, testing parameter assays are disclosed for degradation of pimobendan, dissolution, loss on drying, hardness and disintegration of the tablet. The tablets according to the invention are within the specification limits regarding degradation of pimobendan, dissolution, loss on drying, hardness and disintegration. 
     Suitable packaging materials for tablets according to the invention are selected from, but not limited to: aluminum/aluminum blisters, PVC/PVDC blisters, and HDPE (high density polyethylene bottles). 
     The invention preferably also relates to a tablet according to the invention, characterized in that the tablet is oblong in shape. For such a tablet, characteristics like crushing strength, disintegration, uniformity of weight and content uniformity fulfill the requirements of the European Pharmacopoeia (ISBN/ISSN 92-871-5106-7 of 4.sup.th Edition 2004, Vol. 4.8, European Directorate for the Quality of Medicines (EDQM), European Pharmacopoeia, 226 avenue de Colmar, F-67029 Strasbourg, France, http://www.pheur.org) and the United States Pharmacopoeia (http://www.usp.org; in print: USP-NF, catalog No. 2270001). 
     The invention preferably relates to a solid formulation, and most preferred a tablet according to the invention, characterized in that the solid formulation or tablet comprising 0.5-20 mg pimobendan, preferably of 1.25 mg, 2.5 mg, 5 mg or 10 mg pimobendan, and further comprises lactose (35-50% by weight relative to the dry mass of the solid formulation/tablet=(w/w)), corn starch (25-50% w/w), croscarmellose-sodium (1-5%), citric acid (2.5-10% w/w), artificial beef flavor (5-30% w/w), polyvidone (1-5% w/w), colloidal anhydrous silica (0.1-1, preferably 0.1-0.5% w/w) and magnesium stearate (0.25-1.5% w/w), wherein the percentage by weight of pimobendan contains preferably about 0.25% (w/w) and the sum of the percentages by weight of all ingredients of the solid formulation including pimobendan is 100% (w/w). A skilled man is in a position to prepare such solid formulations, preferably a tablet. Thus, the skilled man knows that he can add to 0.25% (w/w) pimobendan at most 32.625% (w/w) corn starch, 4% (w/w) croscarmellose-sodium 5% (w/w) citric acid, 20% (w/w) artificial beef flavor, 4% (w/w) polyvidone, colloidal, 0.5% (w/w) anhydrous silica, 1% (w/w) magnesium stearate if the amount of lactose to be 32.625% (w/w). Moreover, the skilled man also knows that if he decided to reduce the amount of the artificial beef flavor, for example, to the minimum of 5% (w/w), he can increase the amount of lactose, for example, to 47.625% (w/w). The invention also relates to a solid formulation, preferably a tablet, comprising about 0.25% (w/w) pimobendan and any of the above other ingredients of the solid formulation, preferably the tablet, in the range given above so that the sum of the amounts by weight of the individual formulation ingredients is 100%. 
     The present invention is also directed to a solid formulation, preferably to a tablet, which comprises 1 mg pimobendan, 100-200 mg lactose, 100-200 mg corn starch, 4-20 mg croscarmellose-sodium, 10-40 mg citric acid anhydrous, 20-120 mg artificial beef flavor, 4-20 mg polyvidone, 0.4-4 mg colloidal anhydrous silica, and 1-6 mg magnesium stearate for each 400 mg of total weight of the solid formulation, preferably a tablet. According to a further embodiment of the present invention, the solid formulation, preferably the tablet, comprises 1 mg pimobendan, 120-180 mg lactose, 120-180 mg corn starch, 8-18 mg croscarmellose-sodium, 15-30 mg citric acid anhydrous, 40-100 mg artificial beef flavor, 8-18 mg polyvidone, 0.5-2 mg colloidal anhydrous silica, and 2-5 mg magnesium stearate for each 400 mg of total weight of the solid formulation/tablet. For example, the present invention relates to a solid formulation comprising for each 400 mg of total weight: 1 mg pimobendan, 20 mg citric acid anhydrous, 130.5 mg lactose, 130.5 mg corn starch, 16 mg polyvidone, 16 mg croscarmellose-sodium, 80 mg artificial beef flavor, 4 mg magnesium stearate, and 2 mg colloidal anhydrous silica. A skilled man is in a position to prepare such solid formulation/tablet. The skilled man also knows that he can vary the amount of each ingredient of the solid formulation/tablet within the ranges given above in that the total weight of the solid formulation/tablet for each 1 mg pimobendan is 400 mg. For example, the amount of lactose may be 100, 101, 102, . . . 108, 109, 110 etc.; 111, 112, . . . 118, 119, 120 etc.; 121, 122, . . . 128, 129, 120 etc.; 131, 132, . . . 138, 139, 140 etc.; 141, 142, . . . 148, 149, 150 etc.; 151, 152, . . . 158, 159, 160 etc.; 161, 162, . . . 168, 169, 170 etc.; 171, 172, . . . 178, 179, 180 etc.; 108, 182, . . . 188, 189, 190 etc.; 191, 192, . . . 198, 199, 200 mg for each 400 mg of total weight of the solid formulation, preferably a tablet, comprising about 1 mg pimobendan. In the same manner the amount of corn starch may be 100, 101, 102, . . . 108, 109, 110 etc.; 111, 112, . . . 118, 119, 120 etc.; 121, 122, . . . 128, 129, 120 etc.; 131, 132, . . . 138, 139, 140 etc.; 141, 142, . . . 148, 149, 150 etc.; 151, 152, . . . 158, 159, 160 etc.; 161, 162, . . . 168, 169, 170 etc.; 171, 172, . . . 178, 179, 180 etc.; 108, 182, . . . 188, 189, 190 etc.; 191, 192, . . . 198, 199, 200 mg for each 400 mg of total weight of the solid formulation, preferably a tablet, comprising about 1 mg pimobendan. Furthermore, the amount of citric acid anhydrous may be 10, 11, 12, . . . 18, 19, 20 etc.; 21, 22, . . . 28, 29, 30 etc.; 31, 32, . . . 38, 39, 40 mg for each 400 mg of total weight of the solid formulation, preferably a tablet comprising about 1 mg pimobendan. Furthermore, the amount of artificial beef flavor may be 20, 21, 22, . . . 28, 29, 30 etc.; 31, 32, . . . 38, 39, 40 etc.; 41, 42, . . . 48, 49, 50 etc.; 50, 51, 52, . . . 58, 59, 60 etc.; 61, 62, . . . 68, 69, 70 etc.; 71, 72, . . . 78, 79, 80 etc., 81, 82, 83, . . . 88, 89, 90 etc.; 91, 92, . . . 98, 99, 100 etc.; 101, 102, . . . 108, 109, 110 etc.; 111, 112, . . . 118, 119, 120 mg for each 400 mg of total weight of the solid formulation, preferably a tablet, comprising about 1 mg pimobendan. Furthermore, the amount of polyyidone may be 4, 5, 6, . . . 8, 9, 10 etc.; 11, 12, . . . 18, 19, 20 mg for each 400 mg of total weight of the solid formulation, preferably a tablet, comprising about 1 mg pimobendan. Furthermore, the amount of croscarmellose-sodium may be 4, 5, 6, . . . 8, 9, 10 etc.; 11, 12, . . . 18, 19, 20 mg for each 400 mg of total weight of the solid formulation, preferably a tablet, comprising 1 mg pimobendan. Furthermore, the amount of magnesium stearate may be 1.0, 1.1, 1.2, . . . 1.8, 1.9, 2.0 etc.; 2.1, 2.2, . . . 2.8, 2.9, 3.0 etc.; 3.1, 3.2, . . . 3.8, 3.9, 40 etc.; 4.0, 4.1, 4.2, . . . 4.8, 4.9, 5.0 etc.; 5.1, 5.2, . . . 5.8, 5.9, 6.0 mg for each 400 mg of total weight of the solid formulation, preferably a tablet, comprising about 1 mg pimobendan. Furthermore, the amount of colloidal anhydrous silica may be 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 1.0, 1.1, 1.2, . . . 1.8, 1.9, 2.0 etc.; 2.1, 2.2, . . . 2.8, 2.9, 3.0 etc.; 3.1, 3.2, . . . 3.8, 3.9, 4.0 mg for each 400 mg of total weight of the solid formulation, preferably a tablet, comprising about 1 mg pimobendan. A skilled man is in a position to prepare any of such inventive solid formulation, preferably as a tablet. 
     In another important embodiment, the invention relates to a fluid-bed granulation process comprising the following steps:
         a) an aqueous solution of pimobendan and a binder as defined above is sprayed onto a solid carrier bed comprising one or several carriers and/or excipients as defined above, flavor and citric acid anhydride and   b) the mixture of a) is dried and   c) the mixture of b) is sieved and de-agglomerated and   d) a flow regulator is added to the mixture of c) and   e) a lubricant is added to the mixture of d) and   f) the mixture of e) is blended for uniformity of granules to obtain final granules and/or   g) the final granules of f) are compressed to solid formulations.       

     Step g) is omitted if the solid formulation is a granule. If the solid formulation is a tablet, step g) is carried out. 
     The invention preferably relates to a fluid-bed granulation process comprising the following steps:
         a) an aqueous solution of pimobendan and polyvidone is sprayed onto a solid support comprising lactose, starch, flavor and citric acid anhydride and   b) the mixture of a) is dried and   c) the mixture of b) is sieved and de-agglomerated and   d) a flow regulator is added to the mixture of c) and   e) a lubricant is added to the mixture of d) and   f) the mixture of e) is blended for uniformity of granules to obtain final granules and/or   g) the final granules of f) are tableted.       

     Step g) is omitted if the solid formulation is a granule. If the solid formulation is a tablet, step g) is carried out. 
     Another embodiment is a method of prevention and/or treatment of diseases wherein cardiotonic, hypotensive and anti-thrombotic substances have a therapeutic benefit, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a solid formulation according to the invention as disclosed above. Preferred is a method of prevention and/or treatment of congestive heart failure, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a solid formulation according to the invention as disclosed above. Most preferably, the method comprises administering a tablet according to the invention, characterized in that the tablet comprises 1.25 mg, 2.5 mg, 5 mg or 10 mg pimobendan, and further comprises lactose, corn starch, croscarmellose-sodium, citric acid preferably at an amount of 50 mg/g, artificial beef flavor, polyvidone, colloidal anhydrous silica and magnesium stearate. Preferably also, such treatment is by orally administering the solid formulation according to the invention. 
     The mammal according to the invention is preferably a mammal selected from the group consisting of dogs, cats and rodents such as rabbits. 
     Furthermore, the invention relates to a method for manufacturing a medicament for the prevention and/or treatment of congestive heart failure, characterized in that a solid formulation according to the invention is used. Preferably, the invention relates to a method for manufacturing a medicament for the prevention and/or treatment of congestive heart failure, characterized in that a tablet consisting of 1.25 mg, 2.5 mg, 5 mg or 10 mg pimobendan and further consisting of lactose, corn starch, croscarmellose-sodium, 50 mg/g citric acid, artificial beef flavor, polyvidone, colloidal anhydrous silica and magnesium stearate is used. 
     The present invention furthermore relates to a kit, which comprises a solid formulation, preferably a tablet according to the present invention described herein, and a package leaflet or user instruction including the information concerning how the solid formulation, preferably the tablet, is to used via the oral route for the prevention and/or treatment of congestive heart failure in a mammal in need of such prevention or treatment, preferably in a dog, cat or rodent. 
     EXAMPLES 
     The following examples serve to further illustrate the present invention; but the same should not be construed as limiting the scope of the invention disclosed herein. 
     Example 1 
     Compositions 
     Composition A 
     
       
         
           
               
            
               
                   
               
               
                 Composition A 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                 mg/tablet 
                 mg/tablet 
                 mg/tablet 
                   
                   
               
               
                   
                   
                 1.25 mg 
                 2.5 mg 
                 5.0 mg 
                 Volatile 
               
               
                   
                 Ingredients 
                 chewable 
                 chewable 
                 chewable 
                 ingredient 
                 kg/batch 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 (01) 
                 Pimobendan 
                 1.250 
                 2.500 
                 5.000 
                   
                 0.175 
               
               
                 (02) 
                 Citric acid 
                 25.000 
                 50.000 
                 100.00 
                   
                 3.500 
               
               
                   
                 anhydrous &lt;200 μm 
               
               
                 (03) 
                 Starch 
                 163.125 
                 326.250 
                 652.500 
                   
                 22.8375 
               
               
                 (04) 
                 Lactose, coarse 
                 163.125 
                 326.250 
                 652.500 
                   
                 22.8375 
               
               
                 (05) 
                 Polyvidone 
                 20.000 
                 40.000 
                 80.000 
                   
                 2.800 
               
               
                 (06) 
                 Croscarmellose 
                 20.000 
                 40.000 
                 80.000 
                   
                 2.800 
               
               
                   
                 Sodium 
               
               
                 (07) 
                 Artificial Powered 
                 100.000 
                 200.00 
                 400.000 
                   
                 14.000 
               
               
                   
                 Beef Flavour 
               
               
                 (08) 
                 Silica, colloidal 
                 2.500 
                 5.00 
                 10.000 
                   
                 0.350 
               
               
                   
                 anhydrous 
               
               
                 (09) 
                 Magnesium stearate 
                 5.000 
                 10.00 
                 20.000 
                   
                 0.700 
               
               
                 (10) 
                 Purified water 
                   
                   
                   
                 + 
                   
               
               
                   
                   
                 500.000 
                 1000.000 
                 2000.000 
                 − 
                 70.000 
               
               
                   
               
            
           
         
       
     
     Composition B 
     
       
         
           
               
            
               
                   
               
               
                 Composition B 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 mg/tablet 
                 mg/tablet 
                 mg/tablet 
                   
                   
               
               
                   
                 1.25 mg 
                 2.5 mg 
                 5.0 mg 
                 Volatile 
               
               
                 Ingredients 
                 chewable 
                 chewable 
                 chewable 
                 ingredient 
                 kg/batch 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Pimobendan 
                 1.250 
                 2.500 
                 5.000 
                   
                 0.175 
               
               
                 Citric acid 
                 25.000 
                 50.000 
                 100.000 
                   
                 3.500 
               
               
                 anhydrous &lt;200 μm 
               
               
                 Starch 
                 163.125 
                 326.250 
                 652.500 
                   
                 22.8375 
               
               
                 Lactose, coarse 
                 238.125 
                 476.250 
                 952.500 
                   
                 22.8375 
               
               
                 Polyvidon 
                 20.000 
                 40.000 
                 80.000 
                   
                 2.800 
               
               
                 Croscarmellose 
                 20.000 
                 40.000 
                 80.000 
                   
                 2.800 
               
               
                 Sodium 
               
               
                 Meat Flavour 
                 25.000 
                 50.000 
                 100.000 
                   
                 14.000 
               
               
                 Silica, colloidal 
                 2.500 
                 5.000 
                 10.000 
                   
                 0.350 
               
               
                 anhydrous 
               
               
                 Magnesium stearate 
                 5.000 
                 10.000 
                 20.000 
                   
                 0.700 
               
               
                 Purified water 
                   
                   
                   
                 + 
                   
               
               
                   
                 500.000 
                 1000.000 
                 2000.000 
                 − 
                 70.000 
               
               
                   
               
            
           
         
       
     
     Example 2 
     Raw Materials 
     (01) Pimobendan 
     Function: Active ingredient 
     (02) Citric acid anhydrous &lt;200 μm 
     Function: Diluent, Disintegrant 
     (03) Starch 
     Function: Carrier, Disintegrant 
     (04) Lactose coarse 
     Function: Carrier, Disintegrant 
     (05) Povidone 
     Function: Binder 
     (06) Croscarmellose Sodium 
     Function: Disintegrant 
     (07) Artificial Powdered Beef Flavor 
     Function: Flavor 
     (08) Silica, colloidal anhydrous 
     Function: Flow regulator, Disintegrant 
     (09) Magnesium stearate 
     Function: Lubricant 
     (10) Purified water 
     Function: Solvent 
     Example 3 
     Product Description 
     Appearance: brownish, oblong tablets, with break line. 
     
       
         
           
               
               
               
               
             
               
                   
                   
               
               
                   
                 Tablet 
                 Tablet 
                 Tablet 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Weight 
                 500 
                 mg 
                 1000 
                 mg 
                 2000 
                 mg 
               
               
                 Length 
                 About 19.0 
                 mm 
                 About 24.0 
                 mm 
                 About 25.0 
                 mm 
               
               
                 Width 
                 About 7.0 
                 mm 
                 About 7.5 
                 mm 
                 About 15.0 
                 mm 
               
               
                 Thick- 
                 About 4.2 
                 mm 
                 About 5.6 
                 mm 
                 About 6.0 
                 mm 
               
               
                 ness 
               
               
                   
               
            
           
         
       
     
     Example 4 
     Manufacturing Process 
     1 batch=140000 tablets (1.25 mg Dosage) 
     1 batch=70000 tablets (2.50 mg Dosage) 
     1 batch=35000 tablets (5.00 mg Dosage) 
     1. 1. Granulating 
                                             Transfer in a suitable Granulator after presereening:                                                    (01)   Starch (e.g. 18 mesh sieve)   22.8375   kg       (02)   Lactose (e.g. 18 mesh sieve)   22.8375   kg       (03)   Citric acid anhydrous (e.g. 18 mesh sieve)   3.500   kg       (04)   Croscarmellose sodium (e.g. 18 mesh sieve)   2.800   kg       (05)   Artificial Beef Flavour (e.g. 45 mesh sieve)   14.000   kg       (05)   Povidone (Spray solution)   2.800   kg       (06)   UDCG 115 BS (Spray liquid)   0.175   kg           Premix in the granulator and granulate                   68.950   kg                    
Purified water (e.g. 16.8 kg, range; 12.0-18.0 kg) is used as a solvent for the spray solution povidone and dispersion of pimobendan.
 
     2. Screening 
     
       
         
           
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Screen the premixture 1. 
                 68.950 kg 
               
               
                   
                   
                 68.950 kg 
               
               
                   
                   
               
            
           
         
       
     
     3. Final Mixing 
     
       
         
           
               
               
               
             
               
                   
               
             
            
               
                   
                 Add 
                   
               
               
                 (07) 
                 Sillica, colloidal anhydrous (e.g. 25 mesh sieve) 
                  0.350 kg 
               
               
                 (08) 
                 Magnesium stearate (e.g. 25 mesh sieve) 
                  0.700 kg 
               
               
                   
                 In a tumbling mixer, mix the screened premixture (2.) 
                 70.000 kg 
               
               
                   
                 and the two ingredients 
               
               
                   
                   
                 70.000 kg 
               
               
                   
               
            
           
         
       
     
     4. Compression 
     
       
         
           
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Using a rotary press, compress the final mixture (3.) 
                 70.000 kg 
               
               
                   
                 into tablets of 500 mg, 1000 mg, 2000 mg. 
                   
               
               
                   
                   
                 70.000 kg 
               
               
                   
                   
               
            
           
         
       
     
     5. Packaging 
     Transfer the tablets in a suitable container. 
     The tablets can be packed e.g. by blistering of the tablets in a suitable machine. 
     Example 5 
     In Process Controls 
     1. Granules 
     1.1 Appearance: Brownish, white-speckled granules 
     1.2 Loss on Drying: Determine the loss on drying 
     e.g.: HR73; 3 g/105° C./5 min 
     Target: approx. 3.0% 
     Tolerance limits: below 5.0% 
     2. Tablets 
     2.1 Appearance: Brownish, white-speckled, oblong tablets with breakline 
     2.2 Weight uniformity: 
     
       
         
           
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 1) 1.25 mg chewable 
                 Average weight: 475-525 mg 
               
               
                   
                 2) 2.5 mg chewable 
                 Average weight: 950-1050 mg 
               
               
                   
                 3) 5 mg chewable 
                 Average weight: 1900-2100 mg 
               
               
                   
                   
               
            
           
         
       
     
     2.3 Hardness: Determine the hardness 
     
       
         
           
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 1) 1.25 mg 
                 Target: 140 N 
               
               
                   
                   
                 Tolerance: 60-250 N 
               
               
                   
                 2) 2.5 mg 
                 Target: 160 N 
               
               
                   
                   
                 Tolerance: 60-250 N 
               
               
                   
                 3) 5.0 mg 
                 Target 190 N 
               
               
                   
                   
                 Tolerance: 60-300 N 
               
               
                   
                   
               
            
           
         
       
     
     2.4 Disintegration time: Determine the disintegration time according to USP/EP 
     Tolerance limits: ≦15 minutes with water at 37° C., with disks 
     Example 6 
     Palatability Study 
     A study to investigate the palatability of pimobendan-containing tablets was carried out. For a period of four days, two products were given to twenty or ten dogs, respectively, for voluntary uptake. For example, the following formulations with a content of 5 mg/500 mg active ingredient were examined: 
     
       
         
           
               
               
             
               
                   
               
               
                 Ch. 010122 (tablets with 10% 
                 Ch. 010123 (tablets with 10% 
               
               
                 content of artificial beef flavor) 
                 content of artificial beef flavor) 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Pimobendan 
                 5 
                 mg 
                 Pimobendan 
                 5 
                 mg 
               
               
                 (UD-CG 115 BS) 
                   
                   
                 (UD-CG 115 BS) 
               
               
                 Lactose 
                 85.5 
                 mg 
                 Lactose 
                 55.5 
                 mg 
               
               
                 Corn starch 
                 199.5 
                 mg 
                 Corn starch 
                 129.5 
                 mg 
               
               
                 Croscarmellose- 
                 20 
                 mg 
                 Croscarmellose- 
                 20 
                 mg 
               
               
                 Sodium 
                   
                   
                 Sodium 
               
               
                 Citric acid 
                 100 
                 mg 
                 Citric acid 
                 100 
                 mg 
               
               
                 Artificial Beef 
                 50 
                 mg 
                 Artificial Beef 
                 150 
                 mg 
               
               
                 Flavor 
                   
                   
                 Flavor 
               
               
                 Polyvidone 
                 25 
                 mg 
                 Polyvidone 
                 25 
                 mg 
               
               
                 Macrogol 6000 
                 15 
                 mg 
                 Macrogol 6000 
                 15 
                 mg 
               
               
                   
                 Total: 500 
                 mg 
                   
                 Total: 500 
                 mg 
               
               
                   
               
            
           
         
       
     
     In case of Ch. 010123 in competition with the identical formulation in granulated format, a voluntary uptake was observed in 36 out of 40 possible opportunities (i.e. when offered to 10 dogs for 10 days). This compares to an acceptance rate of 90.0%. 
     In case of Ch. 010222 in competition with a formulation in granulated format of equal quantity with 30% flavor, a voluntary uptake was observed in 31 out of 40 possible opportunities. This compares to an acceptance rate of 77.5%. 
     Example 7 
     Dissolution Profiles 
     Examples for representative dissolution profiles of the tablet according to this invention are as disclosed in  FIG. 3 . 
     Dissolution Profiles, Pimobendan 1.25 mg Tablets 
     Showing 95% Confidence Intervals of the Mean 
     USP Apparatus  2  (Paddle), Rotation Speed 75 rpm, Buffer PH 4.0 Comparison of Dissolution Profiles of Tablets Which Were Stored 1 and 6 Months at 40° C./75% in HDPE Bottles 
     Batch No. PB020049 
     Examples for representative dissolution profiles of the tablet according to this invention are as disclosed in  FIG. 4 . 
     Dissolution Profiles, Pimobendan 1.25 mg Tablets 
     Showing 95% Confidence Intervals of the Mean 
     USP Apparatus  2  (Paddle), Rotation Speed 75 rpm, Buffer pH 4.0 Comparison of Dissolution Profiles of Tablets Which Were Stored 12 Days at 25° C./60% in Open Glass Bottles 
     Batch No. PB010080 
     Dissolution Profiles, Pimobendan 1.25 mg Tablets 
     Manufacturing Variable: Different Compression Forces 
       
     
       
         
           
               
               
               
               
            
               
                   
                   
               
               
                   
                   
                 % Dissolved, mean (n = 6) 
                   
               
               
                   
                 Time 
                 Tablet hardness 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                 Batch No. 
                 (min) 
                 70 N 
                 105 N 
                 135 N 
                 157 N 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                 020102 
                 10 
                 82 
                 82 
                 81 
                 84 
               
               
                   
                   
                 20 
                 98 
                 97 
                 97 
                 98 
               
               
                   
                   
                 30 
                 101 
                 99 
                 100 
                 100 
               
               
                   
                   
                 45 
                 101 
                 101 
                 102 
                 102 
               
               
                   
                   
               
            
           
         
       
     
     Examples for representative dissolution profiles of the tablet according to this invention are as disclosed in  FIG. 5 . 
     Dissolution Profiles, Pimobendan 2.5 mg Tablets 
     Showing 95% Confidence Intervals of the Mean 
     USP Apparatus  2  (Paddle), Rotation Speed 75 rpm, Buffer pH 4.0 Comparison of Dissolution Profiles of Tablets Which Were Stored 3 and 6 Months at 40° C./175% in Alu-Alu Blister 
     Batch No. PB010076 
     Examples for representative dissolution profiles of the tablet according to this invention are as disclosed in  FIG. 6 . 
     Dissolution Profiles, Pimobendan 5.0 mg Tablets 
     Showing 95% Confidence Intervals of the Mean 
     USP Apparatus  2  (Paddle), Rotation Speed 75 rpm, Buffer pH 4.0 Comparison of Dissolution Profiles of Tablets Which Were Stored 6 Months at 40.Degree. C./75%/ in HDPE Bottles 
     Batch No. PB020059 
     Examples for representative dissolution profiles of the tablet according to this invention are as disclosed in  FIG. 7 . 
     Dissolution Profiles, Pimobendan 5.0 mg Tablets 
     Showing 95% Confidence Intervals of the Mean 
     USP Apparatus  2  (Paddle), Rotation Speed 75 rpm, Buffer pH 4.0 Manufacturing Variable: Different Compression Forces 
     Batch No. 020205 
       
     
       
         
           
               
               
            
               
                   
                   
               
               
                   
                 % Dissolved, mean (n = 6) 
               
               
                   
                 Tablet hardness 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Time 
                   
                   
                   
                   
               
               
                 Batch No. 
                 (min) 
                 117 N 
                 150 N 
                 186 N 
                 222 N 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 020205 
                 10 
                 56 
                 56 
                 56 
                 56 
               
               
                   
                 20 
                 76 
                 75 
                 76 
                 76 
               
               
                   
                 30 
                 79 
                 79 
                 80 
                 80 
               
               
                   
                 45 
                 80 
                 80 
                 81 
                 81 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
            
               
                   
               
               
                 Analytical Results for Pimobendan Chewable Tablet Batches Used in Stability Study 
               
            
           
           
               
               
            
               
                   
                 % dissolved in t = 30 minutes, mean (n = 6) 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Tablet 
                   
                   
                 Initial 
                 6 Months 
                 6 Months 
                 6 Months 
               
               
                 strength 
                 Batch No. 
                 Packaging 
                 value 
                 25° C./60% 
                 30° C./70% 
                 40° C./75% 
               
               
                   
               
               
                 1.25 mg  
                 PB020049 
                 HDPE bottle 
                 97 
                 95 
                 94 
                 93 
               
               
                   
                 PB020049 
                 Alu-Alu blister 
                   
                 95 
                 93 
                 94 
               
               
                   
                 PB020049 
                 PVC/PVDC blister 
                   
                 94 
                 93 
                 93 
               
               
                   
                 PB020050 
                 HDPE bottle 
                 94 
                 92 
                 93 
                 91 
               
               
                   
                 PB020050 
                 Alu-Alu blister 
                   
                 92 
                 92 
                 91 
               
               
                   
                 PB020050 
                 PVC/PVDC blister 
                   
                 93 
                 93 
                 92 
               
               
                   
                 PB020051 
                 HDPE bottle 
                 94 
                 93 
                 92 
                 92 
               
               
                   
                 PB020051 
                 Alu-Alu blister 
                   
                 94 
                 93 
                 92 
               
               
                   
                 PB020051 
                 PVC/PVDC blister 
                   
                 93 
                 93 
                 91 
               
               
                 2.5 mg 
                 PB020052 
                 HDPE bottle 
                 98 
                 n.d. 
                 n.d. 
                 93 
               
               
                   
                 PB020052 
                 Alu-Alu blister 
                   
                 n.d. 
                 n.d. 
                 94 
               
               
                   
                 PB020052 
                 PVC/PVDC blister 
                   
                 n.d. 
                 n.d. 
                 92 
               
               
                   
                 PB020053 
                 HDPE bottle 
                 97 
                 n.d. 
                 n.d. 
                 91 
               
               
                   
                 PB020053 
                 Alu-Alu blister 
                   
                 n.d. 
                 n.d. 
                 91 
               
               
                   
                 PB020053 
                 PVC/PVDC blister 
                   
                 n.d. 
                 n.d. 
                 91 
               
               
                   
                 PB020054 
                 HDPE bottle 
                 97 
                 n.d. 
                 n.d. 
                 91 
               
               
                   
                 PB020054 
                 Alu-Alu blister 
                   
                 n.d. 
                 n.d. 
                 92 
               
               
                   
                 PB020054 
                 PVC/PVDC blister 
                   
                 n.d. 
                 n.d. 
                 91 
               
               
                 5.0 mg 
                 PB020059 
                 HDPE bottle 
                 95 
                 93 
                 92 
                 92 
               
               
                   
                 PB020059 
                 Alu-Alu blister 
                   
                 93 
                 92 
                 92 
               
               
                   
                 PB020059 
                 PVC/PVDC blister 
                   
                 92 
                 92 
                 91 
               
               
                   
                 PB020060 
                 HDPE bottle 
                 92 
                 91 
                 90 
                 89 
               
               
                   
                 PB020060 
                 Alu-Alu blister 
                   
                 91 
                 91 
                 90 
               
               
                   
                 PB020060 
                 PVC/PVDC blister 
                   
                 91 
                 91 
                 89 
               
               
                   
                 PB020061 
                 HDPE bottle 
                 94 
                 91 
                 91 
                 89 
               
               
                   
                 PB020061 
                 Alu-Alu blister 
                   
                 92 
                 92 
                 90 
               
               
                   
                 PB020061 
                 PVC/PVDC blister 
                   
                 91 
                 91 
                 89 
               
               
                   
               
               
                 n.d. = not determined 
               
            
           
         
       
     
     Example 8 
     Content Uniformity 
     Samples were taken from both the final blend before tableting and from the tableting process. The following results demonstrate the uniformity of pimobendan content. 
     
       
         
           
               
            
               
                   
               
               
                 Blend Uniformity 
               
            
           
           
               
               
               
               
            
               
                   
                 Batch 
                 Assay [mg/g] 
                 % Target 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 0007LP-A 
                 2.37 
                 94.8 
               
               
                   
                 0007LP-B 
                 2.48 
                 99.2 
               
               
                   
                 0007LP-C 
                 2.43 
                 97.2 
               
               
                   
                 0007LP-D 
                 2.44 
                 97.6 
               
               
                   
                 0007LP-E 
                 2.47 
                 98.8 
               
               
                   
                 0007LP-F 
                 2.50 
                 100.0 
               
               
                   
                 0007LP-G 
                 2.49 
                 99.6 
               
               
                   
                 0007LP-H 
                 2.49 
                 99.6 
               
               
                   
                 0007LP-I 
                 2.50 
                 100.0 
               
               
                   
                 0007LP-J 
                 2.43 
                 97.2 
               
               
                   
                 Average 
                 2.46 
                 98.4 
               
               
                   
                 0008LP-A 
                 2.41 
                 96.4 
               
               
                   
                 0008LP-B 
                 2.48 
                 99.2 
               
               
                   
                 0008LP-C 
                 2.45 
                 98.0 
               
               
                   
                 0008LP-D 
                 2.45 
                 98.0 
               
               
                   
                 0008LP-E 
                 2.46 
                 98.4 
               
               
                   
                 0008LP-F 
                 2.43 
                 97.2 
               
               
                   
                 0008LP-G 
                 2.46 
                 98.4 
               
               
                   
                 0008LP-H 
                 2.44 
                 97.6 
               
               
                   
                 0008LP-I 
                 2.47 
                 98.8 
               
               
                   
                 0008LP-J 
                 2.50 
                 100.0 
               
               
                   
                 Average 
                 2.46 
                 98.2 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
            
               
                   
               
               
                 Uniformity of Process 
               
            
           
           
               
               
               
               
            
               
                   
                 Batch 
                 Assay [mg/g] 
                 % Target 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 PM020080-1 
                 2.48 
                 99.2 
               
               
                   
                 PM020080-2 
                 2.52 
                 100.8 
               
               
                   
                 PM020080-3 
                 2.50 
                 100.0 
               
               
                   
                 PM020080-4 
                 2.52 
                 100.8 
               
               
                   
                 PM020080-5 
                 2.49 
                 99.6 
               
               
                   
                 PM020080-6 
                 2.52 
                 100.8 
               
               
                   
                 Average 
                 2.51 
                 100.2 
               
               
                   
                 PM020081-1 
                 2.45 
                 98.0 
               
               
                   
                 PM020081-2 
                 2.51 
                 100.4 
               
               
                   
                 PM020081-3 
                 2.48 
                 99.2 
               
               
                   
                 PM020081-4 
                 2.45 
                 98.0 
               
               
                   
                 PM020081-5 
                 2.47 
                 98.8 
               
               
                   
                 PM020081-6 
                 2.45 
                 98.0 
               
               
                   
                 Average 
                 2.47 
                 98.7 
               
               
                   
                   
               
            
           
         
       
     
     Example 9 
     Accuracy of Broken Tablets 
     The tablets according to this invention were part of an content uniformity test for the broken tablets. 10 tablets were taken from the beginning, middle and end of the tabletting process and broken into two halves. The pimobendan content was determined. 
     
       
         
           
               
            
               
                   
               
               
                 Pimobendan 5 mg tablet, batch no. 0000251607 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Specification 
                 Start 
                 Middle 
                 End 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 CU min. (mg) 
                 ≧2.13 
                 2.44 
                 2.43 
                 2.41 
               
               
                   
                 CU max. (mg) 
                 ≦2.87 
                 2.61 
                 2.57 
                 2.57 
               
               
                   
                 CU average (mg 
                 2.25-2.62 
                 2.52 
                 2.51 
                 2.50 
               
               
                   
                 RSD (%) 
                 ≦6.0 
                 2.3 
                 1.9 
                 2.0 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
            
               
                   
               
               
                 Pimobendan 1.25 mg tablet, batch no. 0000251604 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Specification 
                 Start 
                 Middle 
                 End 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 CU min. (mg) 
                 ≧0.532 
                 0.577 
                 0.590 
                 0.582 
               
               
                   
                 CU max. (mg) 
                 ≦0.718 
                 0.664 
                 0.650 
                 0.645 
               
               
                   
                 CU average (mg 
                 0.563-0.656 
                 0.621 
                 0.621 
                 0.616 
               
               
                   
                 RSD (%) 
                 ≦6.0 
                 5.4 
                 3.4 
                 3.6 
               
               
                   
                   
               
            
           
         
       
     
     Example 10 
     Stability Data After 24 Months (Dissolution/Assay of Pimobendan/Degradation of Pimobendan) 
       
     
       
         
           
               
            
               
                   
               
               
                 Product: Pimobendan chewable tablets 1.25 mg 
               
            
           
           
               
               
               
               
            
               
                   
                 HDPE bottle (m) 
                 PVC/PVDC (m) 
                 Aluminium blister (m) 
               
               
                   
                   
               
            
           
           
               
            
               
                 Batch No.: PB020049 
               
            
           
           
               
               
               
               
               
            
               
                 Dissolution 
                 25° C./60° C. 
                 0 months 95 (min)-102 
                 0 months 95 (min)-102 
                 0 months 95 (min)-102 
               
               
                   
                   
                 (max)/97 (avg); 24 
                 (max)/97 (avg); 24 
                 (max)/97 (avg); 24 
               
               
                   
                   
                 months 96-99/97 
                 months 96-99/97 
                 months 92-96/94 
               
               
                   
                 30° C./70° C. 
                 0 months 95 (min)-102 
                 0 months 95 (min)-102 
                 0 months 95 (min)-102 
               
               
                   
                   
                 (max)/97 (avg); 24 
                 (max)/97 (avg); 24 
                 (max)/97 (avg); 24 
               
               
                   
                   
                 months 96-97/97 
                 months 96-98/97 
                 months 95-99/97 
               
               
                   
                 40° C./75° C. 
                 0 months 95 (min)-102 
                 0 months 95 (min)-102 
                 0 months 95 (min)-102 
               
               
                   
                   
                 (max)/97 (avg); 6 
                 (max)/97 (avg); 6 
                 (max)/97 (avg); 6 
               
               
                   
                   
                 months 92-94/93 
                 months 91-94/93 
                 months 92-95/94 
               
               
                   
                   
                 Batch No.: PB020049 
               
               
                   
                   
                 HDPE bottle (m) 
                 PVC/PVDC (m) 
                 Aluminium blister (m) 
               
               
                 Assay of 
                 25° C./60° C. 
                 0 months 1.251; 24 
                 0 months 1.251; 24 
                 0 months 1.251; 24 
               
               
                 Pimobendan 
                   
                 months 1.233 
                 months 1.236 
                 months 1.237 
               
               
                   
                 30° C./70° C. 
                 0 months 1.251; 24 
                 0 months 1.251; 24 
                 0 months 1.251; 24 
               
               
                   
                   
                 months 1.229 
                 months 1.242 
                 months 1.236 
               
               
                   
                 40° C./75° C. 
                 0 months 1.251; 6 
                 0 months 1.251; 6 months 
                 0 months 1.251; 6 
               
               
                   
                   
                 months 1.221 
                 1.214 
                 months 1.231 
               
               
                 Degradation of 
                 25° C./60° C. 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                 Pimobendan 
                   
                 2) &lt;0.10 (DU- 
                 2) &lt;0.10 (DU-CG 
                 2) &lt;0.10 (DU-CG 
               
               
                   
                   
                 CG 134 
                 134 BS); 3) &lt;0.10 (any 
                 134 BS); 3) &lt;0.10 (any 
               
               
                   
                   
                 BS); 3) &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 (total); 
                 unspecified); 4) &lt;0.10 (total; 
               
               
                   
                   
                 unspecified); 4) &lt;0.10 (total; 
                 24 months 1) &lt;0.10; 
                 24 months 1) &lt;0.10; 
               
               
                   
                   
                 24 months 
                 2) &lt;0.10; 3) &lt;0.10; 4) &lt;0.10 
                 2) &lt;0.10; 3) &lt;0.10; 
               
               
                   
                   
                 1) &lt;0.10; 2) &lt;0.10; 
                   
                 4) &lt;0.10 
               
               
                   
                   
                 3) &lt;0.10; 4) &lt;0.10 
               
               
                   
                 30° C./7° C. 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 (DU- 
                 2) &lt;0.10 (DU-CG 
                 2) &lt;0.10 (DU-CG 
               
               
                   
                   
                 CG 134 
                 134 BS); 3) &lt;0.10 (any 
                 134 BS); 3) &lt;0.10 (any 
               
               
                   
                   
                 BS); 3) &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 (total); 
                 unspecified); 4) &lt;0.10 (total); 
               
               
                   
                   
                 unspecified); 4) &lt;0.10 (total); 
                 24 months 1) 0.35; 
                 24 months 1) &lt;0.10; 
               
               
                   
                   
                 24 months 
                 2) &lt;0.10; 3) &lt;0.10; 4) 0.35 
                 2) &lt;0.10; 3) &lt;0.10; 
               
               
                   
                   
                 1) &lt;0.10; 2) 0.10; 
                   
                 4) &lt;0.10 
               
               
                   
                   
                 3) &lt;0.10; 4) 0.10 
               
               
                   
                 40° C./75° C. 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 (DU- 
                 2) &lt;0.10 (DU-CG 
                 2) &lt;0.10 (DU-CG 
               
               
                   
                   
                 CG 134 
                 134 BS); 3) &lt;0.10 (any 
                 134 BS); 3) &lt;0.10 (any 
               
               
                   
                   
                 BS); 3) &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 (total); 
                 unspecified); 4) &lt;0.10 (total); 
               
               
                   
                   
                 unspecified); 4) &lt;0.10 (total); 
                 6 months 1) 0.55; 
                 6 months 1) &lt;0.10; 
               
               
                   
                   
                 6 months 1) 0.10; 
                 2) &lt;0.10; 3) &lt;0.10; 4) 0.55 
                 2) &lt;0.10; 3) &lt;0.10; 
               
               
                   
                   
                 2) 0.11; 3) &lt;0.10; 4) 0.21 
                   
                 4) &lt;0.10 
               
            
           
           
               
            
               
                 Batch No.: PB020050 
               
            
           
           
               
               
               
               
               
            
               
                 Dissolution 
                 25° C./60° C. 
                 0 months 91 (min)-96 
                 0 months 91 (min)-96 
                 0 months 91 (min)-96 
               
               
                   
                   
                 (max)/94 (avg); 24 
                 (max)/94 (avg); 24 
                 (max)/94 (avg); 24 
               
               
                   
                   
                 months 96-104/99 
                 months 84-101/95 
                 months 92-96/94 
               
               
                   
                 30° C./70° C. 
                 0 months 91 (min)-96 
                 0 months 91 (min)-96 
                 0 months 91 (min)-96 
               
               
                   
                   
                 (max)/94 (avg); 24 
                 (max)/94 (avg); 24 
                 (max)/94 (avg); 24 
               
               
                   
                   
                 months 94-102/97 
                 months 93-102/97 
                 months 97-105/99 
               
               
                   
                 40° C./75° C. 
                 0 months 91 (min)-96 
                 0 months 91 (min)-96 
                 0 months 91 (min)-96 
               
               
                   
                   
                 (max)/94 (avg); 6 
                 (max)/94 (avg); 6 
                 (max)/94 (avg); 6 
               
               
                   
                   
                 months 91-92/91 
                 months 91-93/92 
                 months 91-92/91 
               
               
                 Assay of 
                 25° C./60° C. 
                 0 months 1.231; 24 
                 0 months 1.231; 24 
                 0 months 1.231; 24 
               
               
                 Pimobendan 
                   
                 months 1.224 
                 months 1.201 
                 months 1.228 
               
               
                   
                 30° C./70° C. 
                 0 months 1.231; 24 
                 0 months 1.231; 24 
                 0 months 1.231; 24 
               
               
                   
                   
                 months 1.213 
                 months 1.217 
                 months 1.230 
               
               
                   
                 40° C./75° C. 
                 0 months 1.231; 6 
                 0 months 1.231; 6 months 
                 0 months 1.231; 6 
               
               
                   
                   
                 months 1.205 
                 1.202 
                 months 1.215 
               
               
                 Degradation of 
                 25° C./60° C. 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                 Pimobendan 
                   
                 2) &lt;0.10 (DU- 
                 2) &lt;0.10 (DU-CG 
                 2) &lt;0.10 (DU-CG 
               
               
                   
                   
                 CG 134 
                 134 BS); 3) &lt;0.10 (any 
                 134 BS); 3) &lt;0.10 (any 
               
               
                   
                   
                 BS); 3) &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 (total); 
                 unspecified); 4) &lt;0.10 (total); 
               
               
                   
                   
                 unspecified); 4) &lt;0.10 (total); 
                 24 months 1) &lt;0.10; 
                 24 months 1) &lt;0.10; 
               
               
                   
                   
                 24 months 
                 2) &lt;0.10; 3) &lt;0.10; 4) &lt;0.10 
                 2) &lt;0.10; 3) &lt;0.10; 
               
               
                   
                   
                 1) &lt;0.10; 2) &lt;0.10; 
                   
                 4) &lt;0.10 
               
               
                   
                   
                 3) &lt;0.10; 4) &lt;0.10 
               
               
                   
                 30° C./7° C. 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 (DU- 
                 2) &lt;0.10 (DU-CG 
                 2) &lt;0.10 (DU-CG 
               
               
                   
                   
                 CG 134 
                 134 BS); 3) &lt;0.10 (any 
                 134 BS); 3) &lt;0.10 (any 
               
               
                   
                   
                 BS); 3) &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 (total); 
                 unspecified); 4) &lt;0.10 (total); 
               
               
                   
                   
                 unspecified); 4) &lt;0.10 (total); 
                 24 months 1) &lt;0.37; 
                 24 months 1) &lt;0.10; 
               
               
                   
                   
                 24 months1) &lt;0.10; 
                 2) &lt;0.10; 3) &lt;0.10; 4) &lt;0.37 
                 2) &lt;0.10; 3) &lt;0.10; 
               
               
                   
                   
                 2) &lt;0.10; 3) &lt;0.10; 
                   
                 4) &lt;0.10 
               
               
                   
                   
                 4) &lt;0.10 
               
               
                   
                 40° C./75° C. 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 (DU- 
                 2) &lt;0.10 (DU-CG 
                 2) &lt;0.10 (DU-CG 
               
               
                   
                   
                 CG 134 
                 134 BS); 3) &lt;0.10 (any 
                 134 BS); 3) &lt;0.10 (any 
               
               
                   
                   
                 BS); 3) &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 (total); 
                 unspecified); 4) &lt;0.10 (total); 
               
               
                   
                   
                 unspecified); 4) &lt;0.10 (total); 
                 6 months 1) 0.58; 
                 6 months 1) &lt;0.10; 
               
               
                   
                   
                 6 months 1) &lt;0.10; 
                 2) &lt;0.10; 3) &lt;0.10; 4) 0.58 
                 2) &lt;0.10; 3) &lt;0.10; 
               
               
                   
                   
                 2) &lt;0.10; 3) &lt;0.10; 
                   
                 4) &lt;0.10 
               
               
                   
                   
                 4) &lt;0.10 
               
            
           
           
               
            
               
                 Batch No.: PB020051 
               
            
           
           
               
               
               
               
               
            
               
                 Dissolution 
                 25° C./60° C. 
                 0 months 92 (min)-95 
                 0 months 92 (min)-95 
                 0 months 92 (min)-95 
               
               
                   
                   
                 (max)/94 (avg); 24 
                 (max)/94 (avg); 24 
                 (max)/94 (avg); 24 
               
               
                   
                   
                 months 92-100/96 
                 months 94-101/97 
                 months 91-100/95 
               
               
                   
                 30° C./70° C. 
                 0 months 92 (min)-95 
                 0 months 92 (min)-95 
                 0 months 92 (min)-95 
               
               
                   
                   
                 (max)/94 (avg); 24 
                 (max)/94 (avg); 24 
                 (max)/94 (avg); 24 
               
               
                   
                   
                 months 92-99/96 
                 months 95-98/97 
                 months 92-100/97 
               
               
                   
                 40° C./75° C. 
                 0 months 92 (min)-95 
                 0 months 92 (min)-95 
                 0 months 92 (min)-95 
               
               
                   
                   
                 (max)/94 (avg); 6 
                 (max)/94 (avg); 6 
                 (max)/94 (avg); 6 
               
               
                   
                   
                 months 91-93/92 
                 months 90-92/91 
                 months 91-94/92 
               
               
                 Assay of 
                 25° C./60° C. 
                 0 months 1.230; 24 
                 0 months 1.230; 24 
                 0 months 1.230; 24 
               
               
                 Pimobendan 
                   
                 months 1.222 
                 months 1.225 
                 months 1.228 
               
               
                   
                 30° C./70° C. 
                 0 months 1.230; 24 
                 0 months 1.230; 24 
                 0 months 1.230; 24 
               
               
                   
                   
                 months 1.214 
                 months 1.221 
                 months 1.230 
               
               
                   
                 40° C./75° C. 
                 0 months 1.230; 6 
                 0 months 1.230; 6 months 
                 0 months 1.230; 6 
               
               
                   
                   
                 months 1.210 
                 1.202 
                 months 1.218 
               
               
                 Degradation of 
                 25° C./60° C. 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                 Pimobendan 
                   
                 2) &lt;0.10 (DU- 
                 2) &lt;0.10 (DU-CG 
                 2) &lt;0.10 (DU-GG 
               
               
                   
                   
                 CG 134 
                 134 BS); 3) &lt;0.10 (any 
                 134 BS); 3) &lt;0.10 (any 
               
               
                   
                   
                 BS); 3) &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 (total); 
                 unspecified); 4) &lt;0.10 (total); 
               
               
                   
                   
                 unspecified); 4) &lt;0.10 (total); 
                 24 months 1) &lt;0.10; 
               
               
                   
                   
                 24 months 
                 2) &lt;0.10; 3) &lt;0.10; 4) &lt;0.10 
               
               
                   
                   
                 1) &lt;0.10; 2) &lt;0.10; 
               
               
                   
                   
                 3) &lt;0.10; 4) &lt;0.10 
               
               
                   
                 30° C./7° C. 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 (DU- 
                 2) &lt;0.10 (DU-CG 
                 2) &lt;0.10 (DU-CG 
               
               
                   
                   
                 CG 134 
                 134 BS); 3) &lt;0.10 (any 
                 134 BS); 3) &lt;0.10 (any 
               
               
                   
                   
                 BS); 3) &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 (total); 
                 unspecified); 4) &lt;0.10 (total); 
               
               
                   
                   
                 unspecified); 4) &lt;0.10 (total); 
                 24 months 1) &lt;0.33; 
               
               
                   
                   
                 24 months 
                 2) &lt;0.10; 3) &lt;0.10; 4) 0.33 
               
               
                   
                   
                 1) &lt;0.10; 2) &lt;0.10; 
               
               
                   
                   
                 3) &lt;0.10; 4) &lt;0.10 
               
               
                   
                 40° C./75° C. 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 (DU- 
                 2) &lt;0.10 (DU-CG 
                 2) &lt;0.10 (DU-CG 
               
               
                   
                   
                 CG 134 
                 134 BS); 3) &lt;0.10 (any 
                 134 BS); 3) &lt;0.10 (any 
               
               
                   
                   
                 BS); 3) &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 (total); 
                 unspecified); 4) &lt;0.10 (total); 
               
               
                   
                   
                 unspecified); 4) &lt;0.10 (total); 
                 6 months 1) &lt;0.54; 
               
               
                   
                   
                 6 months 1) &lt;0.10; 
                 2) &lt;0.10; 3) &lt;0.10; 4) &lt;0.54 
               
               
                   
                   
                 2) 0.10; 3) &lt;0.10; 4) 0.10 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
            
               
                   
               
               
                 Product: Pimobendan chewable tablets 2.5 mg 
               
            
           
           
               
               
               
               
            
               
                   
                 HDPE bottle (m) 
                 PVC/PVDC (m) 
                 Aluminium blister (m) 
               
               
                   
                   
               
            
           
           
               
            
               
                 Batch No.: PB020052 
               
            
           
           
               
               
               
               
               
            
               
                 Dissolution 
                 30° C./70° C. 
                 0 months 97 (min)-99 
                 0 months 97 (min)-99 
                 0 months 97 (min)-99 
               
               
                   
                   
                 (max)/98 (avg); 12 
                 (max)/98 (avg); 12 
                 (max)/98 (avg); 12 
               
               
                   
                   
                 Months 93-95/94 
                 months 93-94/94 
                 months 94-97/96 
               
               
                   
                 40° C./75° C. 
                 0 months 97 (min)-99 
                 0 months 97 (min)-99 
                 0 months 97 (min)-99 
               
               
                   
                   
                 (max)/98 (avg); 6 
                 (max)/98 (avg); 6 
                 (max)/98 (avg); 6 
               
               
                   
                   
                 months 93-94/93 
                 months 91-93/92 
                 months 93-95/94 
               
               
                 Assay of 
                 30° C./70° C. 
                 0 months 2.49; 12 
                 0 months 2.49; 12 months 
                 0 months 2.49; 12 
               
               
                 Pimobendan 
                   
                 months 2.49 
                 2.47 
                 months 2.50 
               
               
                   
                 40° C./75° C. 
                 0 months 2.49; 6 
                 0 months 2.49; 6 months 
                 0 months 2.49; 6 months 
               
               
                   
                   
                 months 2.41 
                 2.41 
                 2.45 
               
               
                 Degradation of 
                 30° C./7° C. 
                 0 months 
                 0 months 
                 0 months 
               
               
                 Pimobendan 
                   
                 1) &lt;0.10 (K2006a); 
                 1) &lt;0.10 (K2006a); 
                 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 (UDCG 134 
                 2) &lt;0.10 (UDCG 134 BS); 
                 2) &lt;0.10 (UDCG 134 
               
               
                   
                   
                 BS); 3) &lt;0.10 (any 
                 3) &lt;0.10 (any 
                 BS); 3) &lt;0.10 (any 
               
               
                   
                   
                 unspecified); 
                 unspecified); 
                 unspecified); 
               
               
                   
                   
                 4) &lt;0.10 (total); 12 
                 4) &lt;0.10 (total); 12 months 
                 4) &lt;0.10 (total); 12 
               
               
                   
                   
                 months 1) &lt;0.10; 
                 1) &lt;0.10; 2) &lt;0.10; 
                 months 1) &lt;0.10; 
               
               
                   
                   
                 2) &lt;0.10; 3) &lt;0.10; 
                 3) &lt;0.10; 4) &lt;0.10 
                 2) &lt;0.10; 3) &lt;0.10; 
               
               
                   
                   
                 4) &lt;0.10 
                   
                 4) &lt;0.10 
               
               
                   
                 40° C./75° C. 
                 0 months 
                 0 months 
                 0 months 
               
               
                   
                   
                 1) &lt;0.10 (K2006a); 
                 1) &lt;0.10 (K2006a); 
                 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 (UDCG 134 
                 2) &lt;0.10 (UDCG 134 BS); 
                 2) &lt;0.10 (UDCG 134 
               
               
                   
                   
                 BS); 3) &lt;0.10 (any 
                 3) &lt;0.10 (any 
                 BS); 3) &lt;0.10 (any 
               
               
                   
                   
                 unspecified); 
                 unspecified); 
                 unspecified); 
               
               
                   
                   
                 4) &lt;0.10 (total); 6 
                 4) &lt;0.10 (total); 6 months 
                 4) &lt;0.10 (total); 6 months 
               
               
                   
                   
                 months 1) &lt;0.10; 
                 1) 0.43; 2) &lt;0.10; 3) &lt;0.10; 
                 1) &lt;0.10; 2) &lt;0.10; 
               
               
                   
                   
                 2) &lt;0.10; 3) &lt;0.10; 
                 4) 0.43 
                 3) &lt;0.10; 4) &lt;0.10 
               
               
                   
                   
                 4) &lt;0.10 
               
            
           
           
               
            
               
                 Batch No.: PB020053 
               
            
           
           
               
               
               
               
               
            
               
                 Dissolution 
                 30° C./70° C. 
                 0 months 96 (min)-98 
                 0 months 96 (min)-98 
                 0 months 96 (min)-98 
               
               
                   
                   
                 (max)/97 (avg); 12 
                 (max)/97 (avg); 12 
                 (max)/97 (avg); 12 
               
               
                   
                   
                 months 92-94/93 
                 months 90-93/92 
                 months 91-95/93 
               
               
                   
                 40° C./75° C. 
                 0 months 96 (min)-98 
                 0 months 96 (min)-98 
                 0 months 96 (min)-98 
               
               
                   
                   
                 (max)/97 (avg); 6 
                 (max)/97 (avg); 6 
                 (max)/97 (avg); 6 
               
               
                   
                   
                 months 89-93/91 
                 months 91-91/91 
                 months 90-92/91 
               
               
                 Assay of 
                 30° C./70° C. 
                 0 months 2.44; 12 
                 0 months 2.44; 12 months 
                 0 months 2.44; 12 
               
               
                 Pimobendan 
                   
                 months 2.44 
                 2.41 
                 months 2.46 
               
               
                   
                 40° C./75° C. 
                 0 months 2.44; 6 
                 0 months 2.44; 6 months 
                 0 months 2.44; 6 months 
               
               
                   
                   
                 months 2.41 
                 2.40 
                 2.40 
               
               
                 Degradation of 
                 30° C./7° C. 
                 0 months 
                 0 months 
                 0 months 
               
               
                 Pimobendan 
                   
                 1) &lt;0.10 (K2006a); 
                 1) &lt;0.10 (K2006a); 
                 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 (UDCG 134 
                 2) &lt;0.10 (UDCG 134 BS); 
                 2) &lt;0.10 (UDCG 134 
               
               
                   
                   
                 BS); 3) &lt;0.10 (any 
                 3) &lt;0.10 (any 
                 BS); 3) &lt;0.10 (any 
               
               
                   
                   
                 unspecified); 
                 unspecified); 
                 unspecified); 
               
               
                   
                   
                 4) &lt;0.10 (total); 12 
                 4) &lt;0.10 (total); 12 months 
                 4) &lt;0.10 (total); 12 
               
               
                   
                   
                 months 1) &lt;0.10; 
                 1) &lt;0.10; 2) &lt;0.10; 
                 months 1) &lt;0.10; 
               
               
                   
                   
                 2) &lt;0.10; 3) &lt;0.10; 
                 3) &lt;0.10; 4) &lt;0.10 
                 2) &lt;0.10; 3) &lt;0.10; 
               
               
                   
                   
                 4) &lt;0.10 
                   
                 4) &lt;0.10 
               
               
                   
                 40° C./75° C. 
                 0 months 
                 0 months 
                 0 months 
               
               
                   
                   
                 1) &lt;0.10 (K2006a); 
                 1) &lt;0.10 (K2006a); 
                 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 (UDCG 134 
                 2) &lt;0.10 (UDCG 134 BS); 
                 2) &lt;0.10 (UDCG 134 
               
               
                   
                   
                 BS); 3) &lt;0.10 (any 
                 3) &lt;0.10 (any 
                 BS); 3) &lt;0.10 (any 
               
               
                   
                   
                 unspecified); 
                 unspecified); 
                 unspecified); 
               
               
                   
                   
                 4) &lt;0.10 (total); 6 
                 4) &lt;0.10 (total); 6 months 
                 4) &lt;0.10 (total); 6 months 
               
               
                   
                   
                 months 1) &lt;0.10; 
                 1) 0.39; 2) &lt;0.10; 3) &lt;0.10; 
                 1) &lt;0.10; 2) &lt;0.10; 
               
               
                   
                   
                 2) &lt;0.10; 3) &lt;0.10; 
                 4) 0.39 
                 3) &lt;0.10; 4) &lt;0.10 
               
               
                   
                   
                 4) &lt;0.10 
               
            
           
           
               
            
               
                 Batch No.: PB020054 
               
            
           
           
               
               
               
               
               
            
               
                 Dissolution 
                 30° C./70° C. 
                 0 months 96 (min)-98 
                 0 months 96 (min)-98 
                 0 months 96 (min)-98 
               
               
                   
                   
                 (max)/97 (avg); 12 
                 (max)/97 (avg); 12 
                 (max)/97 (avg); 12 
               
               
                   
                   
                 months 93-95/94 
                 months 90-93/91 
                 months 93-94/94 
               
               
                   
                 40° C./75° C. 
                 0 months 96 (min)-98 
                 0 months 96 (min)-98 
                 0 months 96 (min)-98 
               
               
                   
                   
                 (max)/97 (avg); 6 
                 (max)/97 (avg); 6 
                 (max)/97 (avg); 6 
               
               
                   
                   
                 months 90-92/91 
                 months 90-92/91 
                 months 91-93/92 
               
               
                 Assay of 
                 30° C./70° C. 
                 0 months 2.45; 12 
                 0 months 2.45; 12 months 
                 0 months 2.45; 12 
               
               
                 Pimobendan 
                   
                 months 2.47 
                 2.45 
                 months 2.44 
               
               
                   
                 40° C./75° C. 
                 0 months 2.45; 6 
                 0 months; 6 months 2.39 
                 0 months 2.45; 6 months 
               
               
                   
                   
                 months 2.40 
                   
                 2.41 
               
               
                 Degradation of 
                 30° C./7° C. 
                 0 months 
                 0 months 
                 0 months 
               
               
                 Pimobendan 
                   
                 1) &lt;0.10 (K2006a); 
                 1) &lt;0.10 (K2006a); 
                 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 (UDCG 134 
                 2) &lt;0.10 (UDCG 134 BS); 
                 2) &lt;0.10 (UDCG 134 
               
               
                   
                   
                 BS); 3) &lt;0.10 (any 
                 3) &lt;0.10 (any 
                 BS); 3) &lt;0.10 (any 
               
               
                   
                   
                 unspecified); 
                 unspecified); 
                 unspecified); 
               
               
                   
                   
                 4) &lt;0.10 (total); 12 
                 4) &lt;0.10 (total); 12 months 
                 4) &lt;0.10 (total); 12 
               
               
                   
                   
                 months 1) &lt;0.10; 
                 1) &lt;0.10; 2) &lt;0.10; 
                 months 1) &lt;0.10; 
               
               
                   
                   
                 2) &lt;0.10; 3) &lt;0.10; 
                 3) &lt;0.10; 4) &lt;0.10 
                 2) &lt;0.10; 3) &lt;0.10; 
               
               
                   
                   
                 4) &lt;0.10 
                   
                 4) &lt;0.10 
               
               
                   
                 40° C./75° C. 
                 0 months 
                 0 months 
                 0 months 
               
               
                   
                   
                 1) &lt;0.10 (K2006a); 
                 1) &lt;0.10 (K2006a); 
                 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 (UDCG 134 
                 2) &lt;0.10 (UDCG 134 BS); 
                 2) &lt;0.10 (UDCG 134 
               
               
                   
                   
                 BS); 3) &lt;0.10 (any 
                 3) &lt;0.10 (any 
                 BS); 3) &lt;0.10 (any 
               
               
                   
                   
                 unspecified); 
                 unspecified); 
                 unspecified); 
               
               
                   
                   
                 4) &lt;0.10 (total); 6 
                 4) &lt;0.10 (total); 6 months 
                 4) &lt;0.10 (total); 6 months 
               
               
                   
                   
                 months 1) &lt;0.10; 
                 1) 0.36; 2) &lt;0.10; 3) &lt;0.10; 
                 1) &lt;0.10; 2) &lt;0.10; 
               
               
                   
                   
                 2) &lt;0.10; 3) &lt;0.10; 
                 4) 0.36 
                 3) &lt;0.10; 4) &lt;0.10 
               
               
                   
                   
                 4) &lt;0.10 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
            
               
                   
               
               
                 Product: Pimobendan chewable tablets 5 mg 
               
            
           
           
               
               
               
               
            
               
                   
                 HDPE bottle (m) 
                 PVC/PVDC (m) 
                 Aluminium blister (m) 
               
               
                   
                   
               
            
           
           
               
            
               
                 Batch No.: PB020059 
               
            
           
           
               
               
               
               
               
            
               
                 Dissolution 
                 25° C./60% 
                 0 months 94 (min)-96 
                 0 months 94 (min)-96 
                 0 months 94 (min)-96 
               
               
                   
                   
                 (max)/95 (avg); 
                 (max)/95 (avg); 24 
                 (max)/95 (avg); 24 
               
               
                   
                   
                 24 months 83-90/88 
                 months 83-92/88 
                 months 85-89/87 
               
               
                   
                 30° C./70° C. 
                 0 months 94 (min)-96 
                 0 months 94 (min)-96 
                 0 months 94 (min)-96 
               
               
                   
                   
                 (max)/95 (avg); 
                 (max)/95 (avg); 24 
                 (max)/95 (avg); 24 
               
               
                   
                   
                 24 months 83-95/89 
                 months 82-97/88 
                 months 83-91/87 
               
               
                   
                 40° C./75° C. 
                 0 months 94 (min)-96 
                 0 months 94 (min)-96 
                 0 months 94 (min)-96 
               
               
                   
                   
                 (max)/95 (avg); 6 
                 (max)/95 (avg); 6 months 
                 (max)/95 (avg); 6 
               
               
                   
                   
                 months 91-92/91 
                 90-92/91 
                 months 81-93/92 
               
               
                 Assay of 
                 25° C./60% 
                 0 month 4.95; 24 
                 0 month 4.95; 24 month 
                 0 month 4.95; 24 month 
               
               
                 Pimobendan 
                   
                 month 4.94 
                 4.92 
                 4.92 
               
               
                   
                 30° C./70° C. 
                 0 month 4.95; 24 
                 0 month 4.95; 24 month 
                 0 month 4.95; 24 month 
               
               
                   
                   
                 month 4.90 
                 4.92 
                 4.96 
               
               
                   
                 40° C./75° C. 
                 0 month 4.95; 6 
                 0 month 4.95; 6 month 
                 0 month 4.95; 6 month 
               
               
                   
                   
                 month 4.88 
                 4.91 
                 4.95 
               
               
                 Degradation of 
                 25° C./60% 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                 Pimobendan 
                   
                 2) &lt;0.10 
                 2) &lt;0.10 (UD-CG 
                 2) &lt;0.10 (UD- 
               
               
                   
                   
                 (UD-CG 134 BS); 3) 
                 134 BS); 3) &lt;0.10 (any 
                 CG 134 BS); 3) &lt;0.10 
               
               
                   
                   
                 &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 
                 (any unspecified); 4) 
               
               
                   
                   
                 unspecified); 4) 
                 (total); 24 months 1) 
                 &lt;0.10 (total); 24 months 
               
               
                   
                   
                 &lt;0.10 (total); 24 
                 &lt;0.10; 2) &lt;0.10; 3) &lt;0.10; 
                 1) &lt;0.10; 2) &lt;0.10; 3) 
               
               
                   
                   
                 months 1) &lt;0.10; 2) 
                 4) &lt;0.10 
                 &lt;0.10; 4) &lt;0.10 
               
               
                   
                   
                 &lt;0.10; 3) &lt;0.10; 4) 
               
               
                   
                   
                 &lt;0.10 
               
               
                   
                 30° C./7° C. 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 
                 2) &lt;0.10 (UD-CG 
                 2) &lt;0.10 (UD- 
               
               
                   
                   
                 (UD-CG 134 BS); 3) 
                 134 BS); 3) &lt;0.10 (any 
                 CG 134 BS); 3) &lt;0.10 
               
               
                   
                   
                 &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 
                 (any unspecified); 4) 
               
               
                   
                   
                 unspecified); 4) 
                 (total); 24 months 1) 
                 &lt;0.10 (total); 24 months 
               
               
                   
                   
                 &lt;0.10 (total); 24 
                 &lt;0.10; 2) &lt;0.10; 3) &lt;0.10; 
                 1) &lt;0.10; 2) &lt;0.10; 3) 
               
               
                   
                   
                 months 1) &lt;0.10; 2) 
                 4) &lt;0.10 
                 &lt;0.10; 4) &lt;0.10 
               
               
                   
                   
                 &lt;0.10; 3) &lt;0.10; 4) 
               
               
                   
                   
                 &lt;0.10 
               
               
                   
                 40° C./75° C. 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 
                 2) &lt;0.10 (UD-CG 
                 2) &lt;0.10 (UD- 
               
               
                   
                   
                 (UD-CG 134 BS); 3) 
                 134 BS); 3) &lt;0.10 (any 
                 CG 134 BS); 3) &lt;0.10 
               
               
                   
                   
                 &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 
                 (any unspecified); 4) 
               
               
                   
                   
                 unspecified); 4) 
                 (total); 6 months 1) 0.23; 
                 &lt;0.10 (total); 6 months 
               
               
                   
                   
                 &lt;0.10 (total); 6 
                 2) &lt;0.10; 3) &lt;0.10; 4) 
                 1) &lt;0.10; 2) &lt;0.10; 3) 
               
               
                   
                   
                 months 1) &lt;0.10; 2) 
                 0.23 
                 &lt;0.10; 4) &lt;0.10 
               
               
                   
                   
                 &lt;0.10; 3) &lt;0.10; 4) &lt;0.10 
               
            
           
           
               
            
               
                 Batch No.: PB020060 
               
            
           
           
               
               
               
               
               
            
               
                 Dissolution 
                 25° C./60% 
                 0 months 91 (min)-94 
                 0 months 91 (min)-94 
                 0 months 91 (min)-94 
               
               
                   
                   
                 (max)/92 (avg); 
                 (max)/92 (avg); 24 
                 (max)/92 (avg); 24 
               
               
                   
                   
                 24 months 85-90/87 
                 months 84-90/86 
                 months 82-88/86 
               
               
                   
                 30° C./70° C. 
                 0 months 91 (min)-94 
                 0 months 91 (min)-94 
                 0 months 91 (min)-94 
               
               
                   
                   
                 (max)/92 (avg); 
                 (max)/92 (avg); 24 
                 (max)/92 (avg); 24 
               
               
                   
                   
                 24 months 85-90/87 
                 months 82-90/87 
                 months 86-90/88 
               
               
                   
                 40° C./75° C. 
                 0 months 94 (min)-96 
                 0 months 91 (min)-94 
                 0 months 91 (min)-94 
               
               
                   
                   
                 (max)/95 (avg); 6 
                 (max)/92 (avg); 6 months 
                 (max)/92 (avg); 6 
               
               
                   
                   
                 months 88-89/89 
                 88-90/89 
                 months 89-92/90 
               
               
                 Assay of 
                 25° C./60% 
                 0 month 4.87; 24 
                 0 month 4.87; 24 month 
                 0 month 4.87; 24 month 
               
               
                 Pimobendan 
                   
                 month 4.88 
                 4.86 
                 4.90 
               
               
                   
                 30° C./70° C. 
                 0 month 4.87; 24 
                 0 month 4.87; 24 month 
                 0 month 4.84; 24 month 
               
               
                   
                   
                 month 4.83 
                 4.86 
                 4.89 
               
               
                   
                 40° C./75° C. 
                 0 month 4.87; 6 
                 0 month 4.87; 6 month 
                 0 month 4.87; 6 month 
               
               
                   
                   
                 month 4.86 
                 4.87 
                 4.86 
               
               
                 Degradation of 
                 25° C./60% 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                 Pimobendan 
                   
                 2) &lt;0.10 
                 2) &lt;0.10 (UD-CG 
                 2) &lt;0.10 (UD- 
               
               
                   
                   
                 (UD-CG 134 BS); 3) 
                 134 BS); 3) &lt;0.10 (any 
                 CG 134 BS); 3) &lt;0.10 
               
               
                   
                   
                 &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 
                 (any unspecified); 4) 
               
               
                   
                   
                 unspecified); 4) 
                 (total); 24 months 1) 
                 &lt;0.10 (total); 24 months 
               
               
                   
                   
                 &lt;0.10 (total); 24 
                 &lt;0.10; 2) &lt;0.10; 3) &lt;0.10; 
                 1) &lt;0.10; 2) &lt;0.10; 3) 
               
               
                   
                   
                 months 1) &lt;0.10; 2) 
                 4) &lt;0.10; 
                 &lt;0.10; 4) &lt;0.10; 
               
               
                   
                   
                 &lt;0.10; 3) &lt;0.10; 4) 
               
               
                   
                   
                 &lt;0.10; 
               
               
                   
                 30° C./7° C. 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 
                 2) &lt;0.10 (UD-CG 
                 2) &lt;0.10 (UD- 
               
               
                   
                   
                 (UD-CG 134 BS); 3) 
                 134 BS); 3) &lt;0.10 (any 
                 CG 134 BS); 3) &lt;0.10 
               
               
                   
                   
                 &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 
                 (any unspecified); 4) 
               
               
                   
                   
                 unspecified); 4) 
                 (total); 24 months 1) 
                 &lt;0.10 (total); 24 months 
               
               
                   
                   
                 &lt;0.10 (total); 24 
                 &lt;0.10; 2) &lt;0.10; 3) &lt;0.10; 
                 1) &lt;0.10; 2) &lt;0.10; 3) 
               
               
                   
                   
                 months 1) &lt;0.10; 2) 
                 4) &lt;0.10; 
                 &lt;0.10; 4) &lt;0.10; 
               
               
                   
                   
                 &lt;0.10; 3) &lt;0.10; 4) 
               
               
                   
                   
                 &lt;0.10; 
               
               
                   
                 40° C./75° C. 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 
                 2) &lt;0.10 (UD-CG 
                 2) &lt;0.10 (UD- 
               
               
                   
                   
                 (UD-CG 134 BS); 3) 
                 134 BS); 3) &lt;0.10 (any 
                 CG 134 BS); 3) &lt;0.10 
               
               
                   
                   
                 &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 
                 (any unspecified); 4) 
               
               
                   
                   
                 unspecified); 4) 
                 (total); 24 months 1) 
                 &lt;0.10 (total); 6 months 
               
               
                   
                   
                 &lt;0.10 (total); 6 
                 &lt;0.10; 2) &lt;0.10; 3) &lt;0.10; 
                 1) &lt;0.10; 2) &lt;0.10; 3) 
               
               
                   
                   
                 months 1) &lt;0.10; 2) 
                 4) &lt;0.10; 6 months 1) 
                 &lt;0.10; 4) &lt;0.10 
               
               
                   
                   
                 &lt;0.10; 3) &lt;0.10; 4) 
                 0.22; 2) &lt;0.10; 3) &lt;0.10; 
               
               
                   
                   
                 &lt;0.10 
                 4) 0.22 
               
            
           
           
               
            
               
                 Batch No.: PB020061 
               
            
           
           
               
               
               
               
               
            
               
                 Dissolution 
                 25° C./60% 
                 0 months 92 (min)-95 
                 0 months 92 (min)-95 
                 0 months 92 (min)-95 
               
               
                   
                   
                 (max)/94 (avg); 
                 (max)/94 (avg); 24 
                 (max)/94 (avg); 24 
               
               
                   
                   
                 24 months 83-90/87 
                 months 86-91/88 
                 months 65-92/84 
               
               
                   
                 30° C./70° C. 
                 0 months 92 (min)-95 
                 0 months 92 (min)-95 
                 0 months 92 (min)-95 
               
               
                   
                   
                 (max)/94 (avg); 
                 (max)/94 (avg); 24 
                 (max)/94 (avg); 24 
               
               
                   
                   
                 24 months 84-88/87 
                 months 81-87/85 
                 months 88-91/90 
               
               
                   
                 40° C./75° C. 
                 0 months 92 (min)-95 
                 0 months 92 (min)-95 
                 0 months 92 (min)-95 
               
               
                   
                   
                 (max)/94 (avg); 6 
                 (max)/94 (avg); 6 months 
                 (max)/94 (avg); 6 
               
               
                   
                   
                 months 88-90/89 
                 88-90/89 
                 months 88-91/90 
               
               
                 Assay of 
                 25° C./60% 
                 0 month 4.87; 24 
                 0 month 4.87; 24 month 
                 0 month 4.87; 24 month 
               
               
                 Pimobendan 
                   
                 month 4.83 
                 4.85 
                 4.88 
               
               
                   
                 30° C./70° C. 
                 0 month 4.87; 24 
                 0 month 4.87; 24 month 
                 0 month 4.87; 24 month 
               
               
                   
                   
                 month 4.82 
                 4.80 
                 4.90 
               
               
                   
                 40° C./75° C. 
                 0 month 4.87; 6 
                 0 month 4.87; 6 month 
                 0 month 4.87; 6 month 
               
               
                   
                   
                 month 4.83 
                 4.82 
                 4.88 
               
               
                 Degradation of 
                 25° C./60% 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                 Pimobendan 
                   
                 2) &lt;0.10 
                 2) &lt;0.10 (UD-CG 
                 2) &lt;0.10 (UD- 
               
               
                   
                   
                 (UD-CG 134 BS); 3) 
                 134 BS); 3) &lt;0.10 (any 
                 CG 134 BS); 3) &lt;0.10 
               
               
                   
                   
                 &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 
                 (any unspecified); 4) 
               
               
                   
                   
                 unspecified); 4) 
                 (total); 24 months 1) 
                 &lt;0.10 (total); 24 months 
               
               
                   
                   
                 &lt;0.10 (total); 24 
                 &lt;0.10; 2) &lt;0.10; 3) &lt;0.10; 
                 1) &lt;0.10; 2) &lt;0.10; 3) 
               
               
                   
                   
                 months 1) &lt;0.10; 2) 
                 4) &lt;0.10; 
                 &lt;0.10; 4) &lt;0.10 
               
               
                   
                   
                 &lt;0.10; 3) &lt;0.10; 4) 
               
               
                   
                   
                 &lt;0.10; 
               
               
                   
                 30° C./7° C. 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 
                 2) &lt;0.10 (UD-CG 
                 2) &lt;0.10 (UD- 
               
               
                   
                   
                 (UD-CG 134 BS); 3) 
                 134 BS); 3) &lt;0.10 (any 
                 CG 134 BS); 3) &lt;0.10 
               
               
                   
                   
                 &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 
                 (any unspecified); 4) 
               
               
                   
                   
                 unspecified); 4) 
                 (total); 24 months 1) 
                 &lt;0.10 (total); 24 months 
               
               
                   
                   
                 &lt;0.10 (total); 24 
                 &lt;0.10; 2) &lt;0.10; 3) &lt;0.10; 
                 1) &lt;0.10; 2) &lt;0.10; 3) 
               
               
                   
                   
                 months 1) &lt;0.10; 2) 
                 4) &lt;0.10; 
                 &lt;0.10; 4) &lt;0.10; 
               
               
                   
                   
                 &lt;0.10; 3) &lt;0.10; 4) 
               
               
                   
                   
                 &lt;0.10; 
               
               
                   
                 40° C./75° C. 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
                 0 months 1) &lt;0.10 (K2006a); 
               
               
                   
                   
                 2) &lt;0.10 
                 2) &lt;0.10 (UD-CG 
                 2) &lt;0.10 (UD- 
               
               
                   
                   
                 (UD-CG 134 BS); 3) 
                 134 BS); 3) &lt;0.10 (any 
                 CG 134 BS); 3) &lt;0.10 
               
               
                   
                   
                 &lt;0.10 (any 
                 unspecified); 4) &lt;0.10 
                 (any unspecified); 4) 
               
               
                   
                   
                 unspecified); 4) 
                 (total); 6 months 1) 0.22; 
                 &lt;0.10 (total); 6 months 
               
               
                   
                   
                 &lt;0.10 (total); 6 
                 2) &lt;0.10; 3) &lt;0.10; 4) 
                 1) &lt;0.10; 2) &lt;0.10; 3) 
               
               
                   
                   
                 months 1) &lt;0.10; 2) 
                 0.22 
                 &lt;0.10; 4) &lt;0.10 
               
               
                   
                   
                 &lt;0.10; 3) &lt;0.10; 4) 
               
               
                   
                   
                 &lt;0.10