Patent Publication Number: US-2018042233-A1

Title: Nitrogen-containing heterocyclic derivative having 2-imino group and pest control agent including the same

Description:
TECHNICAL FIELD 
     The present invention relates to a nitrogen-containing heterocyclic derivative having a 2-imino group, and a novel pest control agent using the same. 
     BACKGROUND ART 
     Although numerous pest control agents have been discovered so far, novel drugs are still required in view of the problem of reduction in drug sensitivity, long-term efficacy, safety during the use thereof and the like. 
     In particular, for rice cultivation in East Asia and Southeast Asia, damage by planthoppers that have developed drug resistance against main insecticides including Neonicotinoids represented by imidacloprid is materializing and a specific medicine against planthoppers that have developed drug resistance is expected. 
     European Patent Application Laid-Open No. 432600(PTL1) discloses a plurality of compounds having the same ring structure as a compound represented by Formula (I), but the compounds are used as herbicides and there is no description about pest control. 
     European Patent Application Laid-Open No. 268915(PTL2) discloses the structural formula of N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide, but there is no description about the pest control by compounds having other structures. 
     Japanese Patent Application Laid-Open No. 5-78323(PTL3) discloses a compound similar to the compound represented by Formula (I), but the compound has a structure different from the compound of the present invention, in that R in Formula (I) is an acyl group having a benzene ring, an acyl group having a hetero ring, an alkylsulfonyl group, an alkylaminocarbonyl group and an alkylaminothiocarbonyl group. The biological activity thereof is an insecticidal activity, but the compound of the present invention does not suggest significantly high activity against a wide range of insect species. 
     International Publication No. 2006/051704(PTL4) discloses a compound similar to Formula (I) of the present invention, but fails to specifically disclose the compound represented by Formula (I) and does not suggest the content of the present invention about pest control activity. 
     European Patent Application Laid-Open No. 259738(PTL5) discloses a plurality of compounds having a ring structure similar to that of a compound represented by Formula (I), but fails to disclose or suggest a compound having a trifluoroacetic acid imino structure. 
     CITATION LIST 
     Patent Literature 
     
         
         [PTL 1] European Patent Application Laid-Open No. 432600 
         [PTL 2] European Patent Application Laid-Open No. 268915 
         [PTL 3] Japanese Patent Application Laid-Open No. 5-78323 
         [PTL 4] International Publication No. 2006/051704 
         [PTL 5] European Patent Application Laid-Open No. 259738 
       
    
     SUMMARY OF INVENTION 
     Technical Problem 
     The present invention is contrived to provide a novel pest control agent to solve problems which chemicals in the related art have, such as reduction in drug sensitivity, long-term efficacy, safety during the use thereof and the like in the field of pest control. 
     One of the important problems in the present invention is to provide a chemical which has excellent pest control effects against  Nilaparvata lugens, Sogatella furcifera  and  Laodelphax striatella , which has recently become major pests in the field of rice, exhibits high activity even against drug-resistant planthoppers, reduces the chance that workers are exposed to the chemical during the use thereof such as soil treatment, seed treatment, nursery box treatment and may be safely used. 
     Solution to Problem 
     In order to solve the problems, the present inventors have intensively studied, and as a result, have found that a nitrogen-containing heterocyclic derivative having a 2-imino group, which is represented by Chemical Formula (I), has excellent activity as a pest control agent. 
     That is, according to the present invention, the following inventions are provided. 
     (1) A nitrogen-containing heterocyclic derivative having a 2-imino group, which is represented by the following Formula (I), or salts thereof. 
     
       
         
         
             
             
         
       
     
     Formula (I) 
     [in the formula, Ar represents a phenyl group which may be substituted, a 5- to 6-membered heterocycle which may be substituted, or a 4- to 10-membered heterocycloalkyl group, 
     A represents a heterocycle having a 5- to 10-membered unsaturated bond including one or more nitrogen atoms, and has an imino group substituted with an R group at a position adjacent to the nitrogen atom present on the cycle, 
     Y represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1 to C6 alkyl group which may be substituted with a halogen atom, a C1 to C6 alkyloxy group which may be substituted with a halogen atom, a cyano group, or a nitro group, and 
     R represents any one of groups represented by the following Formulae (a) to (e), (y) or (z), 
     
       
         
         
             
             
         
       
     
     [where, R1 represents a hydrogen atom, a substituted C1 to C6 alkyl group, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, or a pentafluorophenyl group, 
     R2 represents a C1 to C6 alkyl group substituted with a halogen atom, an unsubstituted C3 to C6 branched or cyclic alkyl group, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a substituted or unsubstituted (C6 to C10) aryl group, a substituted or unsubstituted 5- to 10-membered heterocycle, or a substituted or unsubstituted benzyl group, 
     R3 represents a C1 to C6 alkyl group which may be substituted with a halogen atom, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a substituted or unsubstituted (C6 to C10) aryl group, a substituted or unsubstituted (C6 to C10) aryl (C1 to C6) alkyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkenyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkynyl group, a substituted or unsubstituted phenoxy (C1 to C6) alkyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkenyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkynyl group, a substituted or unsubstituted 5- to 10-membered heterocycle, a substituted or unsubstituted 5- to 10-membered heterocycle (C1 to C6) alkyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkenyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkynyl group, a (C1 to C4) alkoxy (C1 to C5) alkyl group, a (C1 to C4) alkoxy (C2 to C5) alkenyl group, a (C1 to C4) alkoxy (C2 to C5) alkynyl group, a (C1 to C4) alkylthio (C1 to C5) alkyl group, a (C1 to C4) alkylthio (C2 to C5) alkenyl group, or a (C1 to C4) alkylthio (C2 to C5) alkynyl group, 
     R4 represents a hydrogen atom, a formyl group, a C1 to C18 alkyl group which may be substituted, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a substituted or unsubstituted (C6 to C10) aryl group, a substituted or unsubstituted (C6 to C10) aryl (C1 to C6) alkyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkenyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkynyl group, a substituted or unsubstituted phenoxy (C1 to C6) alkyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkenyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkynyl group, a substituted or unsubstituted 5- to 10-membered heterocycle, a substituted or unsubstituted 5- to 10-membered heterocycle (C1 to C6) alkyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkenyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkynyl group, a (C1 to C4) alkoxy (C1 to C5) alkyl group, a (C1 to C4) alkoxy (C2 to C5) alkenyl group, a (C1 to C4) alkoxy (C2 to C5) alkynyl group, a (C1 to C4) alkylthio (C1 to C5) alkyl group, a (C1 to C4) alkylthio (C2 to C5) alkenyl group, a (C1 to C4) alkylthio (C2 to C5) alkynyl group, or a group represented by the following Formulae (f) to (n), 
     
       
         
         
             
             
         
       
     
     where, R4a, R4b and R4c represent a C1 to C6 alkyl group which may be substituted with a halogen atom, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a substituted or unsubstituted (C6 to C10) aryl group, a substituted or unsubstituted (C6 to C10) aryl (C1 to C6) alkyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkenyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkynyl group, a substituted or unsubstituted phenoxy (C1 to C6) alkyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkenyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkynyl group, a substituted or unsubstituted 5- to 10-membered heterocycle, a substituted or unsubstituted 5- to 10-membered heterocycle (C1 to C6) alkyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkenyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkynyl group, a (C1 to C4) alkoxy (C1 to C5) alkyl group, a (C1 to C4) alkoxy (C2 to C5) alkenyl group, a (C1 to C4) alkoxy (C2 to C5) alkynyl group, a (C1 to C4) alkylthio (C1 to C5) alkyl group, a (C1 to C4) alkylthio (C2 to C5) alkenyl group, or a (C1 to C4) alkylthio (C2 to C5) alkynyl group, 
     R4d represents a C1 to C6 alkyl group which may be substituted with a halogen atom, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a substituted or unsubstituted (C6 to C10) aryl group, or a substituted or unsubstituted 5- to 10-membered heterocycle, and 
     R4e and R4f each independently represent a hydrogen atom, a C1 to C6 alkyl group which may be substituted with a halogen atom, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a substituted or unsubstituted (C6 to C10) aryl group, or a substituted or unsubstituted 5- to 10-membered heterocycle, 
     R5 represents a C1 to C6 alkyl group which may be substituted with a halogen atom, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a substituted or unsubstituted (C6 to C10) aryl group, a substituted or unsubstituted (C6 to C10) aryl (C1 to C6) alkyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkenyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkynyl group, a substituted or unsubstituted phenoxy (C1 to C6) alkyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkenyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkynyl group, a substituted or unsubstituted 5- to 10-membered heterocycle, a substituted or unsubstituted 5- to 10-membered heterocycle (C1 to C6) alkyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkenyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkynyl group, a (C1 to C4) alkoxy (C1 to C5) alkyl group, a (C1 to C4) alkoxy (C2 to C5) alkenyl group, a (C1 to C4) alkoxy (C2 to C5) alkynyl group, a (C1 to C4) alkylthio (C1 to C5) alkyl group, a (C1 to C4) alkylthio (C2 to C5) alkenyl group, or a (C1 to C4) alkylthio (C2 to C5) alkynyl group, 
     R6 represents a hydrogen atom, a formyl group, a O,O′—C1 to C4 alkyl phosphoryl group, a C1 to C18 alkyl group which may be substituted, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a substituted or unsubstituted (C6 to C10) aryl group, a substituted or unsubstituted (C6 to C10) aryl (C1 to C6) alkyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkenyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkynyl group, a substituted or unsubstituted phenoxy (C1 to C6) alkyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkenyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkynyl group, a substituted or unsubstituted 5- to 10-membered heterocycle, a substituted or unsubstituted 5- to 10-membered heterocycle (C1 to C6) alkyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkenyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkynyl group, a (C1 to C4) alkoxy (C1 to C5) alkyl group, a (C1 to C4) alkoxy (C2 to C5) alkenyl group, a (C1 to C4) alkoxy (C2 to C5) alkynyl group, a (C1 to C4) alkylthio (C1 to C5) alkyl group, a (C1 to C4) alkylthio (C2 to C5) alkenyl group, a (C1 to C4) alkylthio (C2 to C5) alkynyl group, or a group represented by the following Formulae (o) to (x) 
     
       
         
         
             
             
         
       
     
     where, R6a, R6b and R6c represent a (C1 to C6) alkyl group which may be substituted with a halogen atom, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a substituted or unsubstituted (C6 to C10) aryl group, a substituted or unsubstituted (C6 to C10) aryl (C1 to C6) alkyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkenyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkynyl group, a substituted or unsubstituted phenoxy (C1 to C6) alkyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkenyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkynyl group, a substituted or unsubstituted 5- to 10-membered heterocycle, a substituted or unsubstituted 5- to 10-membered heterocycle (C1 to C6) alkyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkenyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkynyl group, a (C1 to C4) alkoxy (C1 to C5) alkyl group, a (C1 to C4) alkoxy (C2 to C5) alkenyl group, a (C1 to C4) alkoxy (C2 to C5) alkynyl group, a (C1 to C4) alkylthio (C1 to C5) alkyl group, a (C1 to C4) alkylthio (C2 to C5) alkenyl group, or a (C1 to C4) alkylthio (C2 to C5) alkynyl group, 
     R6d represents a C1 to C6 alkyl group which may be substituted with a halogen atom, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a substituted or unsubstituted (C6 to C10) aryl group, or a substituted or unsubstituted 5- to 10-membered heterocycle, 
     R6e and R6f each independently represent a hydrogen atom, a C1 to C6 alkyl group which may be substituted with a halogen atom, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a (C1 to C4) alkoxy (C1 to C5) alkyl group, a (C1 to C4) alkylthio (C1 to C5) alkyl group, a substituted or unsubstituted (C6 to C10) aryl group, a substituted or unsubstituted (C6 to C10) aryl (C1 to C6) alkyl group, or a substituted or unsubstituted 5- to 10-membered heterocycle, 
     R6g and R6h each independently represent a hydrogen atom, a C1 to C6 alkyl group which may be substituted with a halogen atom, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a substituted or unsubstituted (C6 to C10) aryl group, or a substituted or unsubstituted 5- to 10-membered heterocycle, and 
     R6i, R6j and R6k each independently represent a hydrogen atom, a C1 to C6 alkyl group which may be substituted with a halogen atom, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, or a substituted or unsubstituted (C6 to C10) aryl group), and 
     R7 represents a C1 to C6 alkyl group which may be substituted with a halogen atom, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a substituted or unsubstituted (C6 to C10) aryl group, a substituted or unsubstituted (C6 to C10) aryl (C1 to C6) alkyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkenyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkynyl group, a substituted or unsubstituted phenoxy (C1 to C6) alkyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkenyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkynyl group, a substituted or unsubstituted 5- to 10-membered heterocycle, a substituted or unsubstituted 5- to 10-membered heterocycle (C1 to C6) alkyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkenyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkynyl group, a (C1 to C4) alkoxy (C1 to C5) alkyl group, a (C1 to C4) alkoxy (C2 to C5) alkenyl group, a (C1 to C4) alkoxy (C2 to C5) alkynyl group, a (C1 to C4) alkylthio (C1 to C5) alkyl group, a (C1 to C4) alkylthio (C2 to C5) alkenyl group, or a (C1 to C4) alkylthio (C2 to C5) alkynyl group, 
     Y1 and Y2 represent an oxygen atom or a sulfur atom, and may be the same or different, and Ry represents a C1 to C6 alkyl group which may be substituted with a halogen atom, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a substituted or unsubstituted (C6 to C10) aryl group, a substituted or unsubstituted (C6 to C10) aryl (C1 to C6) alkyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkenyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkynyl group, a substituted or unsubstituted phenoxy (C1 to C6) alkyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkenyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkynyl group, a substituted or unsubstituted 5- to 10-membered heterocycle, a substituted or unsubstituted 5- to 10-membered heterocycle (C1 to C6) alkyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkenyl group, or a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkynyl group, 
     Rz represents a C1 to C6 alkyl group which may be substituted with a halogen atom, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a substituted or unsubstituted (C6 to C10) aryl group, a substituted or unsubstituted (C6 to C10) aryl (C1 to C6) alkyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkenyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkynyl group, a substituted or unsubstituted phenoxy (C1 to C6) alkyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkenyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkynyl group, a substituted or unsubstituted 5- to 10-membered heterocycle, a substituted or unsubstituted 5- to 10-membered heterocycle (C1 to C6) alkyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkenyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkynyl group, a (C1 to C4) alkoxy (C1 to C5) alkyl group, a (C1 to C4) alkoxy (C2 to C5) alkenyl group, a (C1 to C4) alkoxy (C2 to C5) alkynyl group, a (C1 to C4) alkylthio (C1 to C5) alkyl group, a (C1 to C4) alkylthio (C2 to C5) alkenyl group, or a (C1 to C4) alkylthio (C2 to C5) alkynyl group, and n represents 1 or 2, 
     here, Ar represents a 6-chloro-3-pyridyl group, A represents a ring represented by the following Formula (A-1), which may be substituted with a methyl group or a halogen atom: 
     
       
         
         
             
             
         
       
     
     where R represents an (a) group in this formula, R1 does not represent a methyl group, a difluoromethyl group, a trifluoromethyl group, a chlorodifluoromethyl group, a chloromethyl group, a dichloromethyl group, a trichloromethyl group, a bromochloromethyl group, a bromomethyl group, a dibromomethyl group, or a pentafluoromethyl group, and where R represents a (b) group of this formula, R2 does not represent an ethyl group, respectively, and 
     A represents a cycle denoted by the formula (A-1) which may be substituted with a halogen atom, and where R represents an (a) group of this formula, and R1 represents a trifluoromethyl group, Ar does not represent a 2-chloro-5-thiazolyl group, a phenyl group, a 4-chlorophenyl group, a 3-pyridyl group, a 6-chloro-5-fluoro-3-pyridyl group, a 6-fluoro-3-pyridyl group, a 5,6-dichloropyridyl group, a 6-bromo-3-pyridyl group, or a 2-chloro-5-pyrimidyl group. 
     In addition, the compounds indicated in tables 1 and 2 below are not included.] 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Compound 
                   
                   
                   
                   1 H-NMR (CDCl3, 
                 IR (KBr, v, 
               
               
                 No. 
                 Ar 
                 R1a 
                 Y 
                 δ, ppm) 
                 cm −1 ) or MS 
               
               
                   
               
               
                 P212 
                 6-chloro-3-pyridyl 
                 CF3 
                 H 
                 5.57 (2H, s), 6.92 (1H, td), 7.31 (1H, 
                 m/z = 316 
               
               
                   
                   
                   
                   
                 d), 7.80 (1H, td), 7.87 (1H, dd), 7.99 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, dd), 8.48 (2H, m) 
                   
               
               
                 P213 
                 2-chloro-5-thiazolyl 
                 CF3 
                 H 
                 5.61 (2H, s), 6.93 (1H, dd), 7.68 (1H, 
                 m/z = 322 
               
               
                   
                   
                   
                   
                 s), 7.83 (1H, td), 7.97 (1H, d), 8.53 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, d) 
                   
               
               
                 P214 
                 6-chloro-3-pyridyl 
                 OCH3 
                 H 
                 3.74 (3H, s), 5.40 (2H, s), 6.45 (1H, 
                 m/z = 278 
               
               
                   
                   
                   
                   
                 td), 7.29 (1H, d), 7.46 (2H, m), 7.73 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, dd), 8.12 (1H, dd), 8.40 (1H, d) 
                   
               
               
                 P215 
                 6-chloro-3-pyridyl 
                 CF3 
                 5-Cl 
                 5.53 (2H, s), 7.34 (1H, d), 7.71 (1H, 
                 m/z = 350 
               
               
                   
                   
                   
                   
                 dd), 7.87 (1H, dd), 7.94 (1H, d), 8.49 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, d), 8.55 (1H, s) 
                   
               
               
                 P216 
                 6-chloro-3-pyridyl 
                 CF3 
                 5-F 
                 5.54 (2H, s), 7.34 (1H, d), 7.70 (1H, 
                 m/z = 334 
               
               
                   
                   
                   
                   
                 m), 7.80 (1H, m), 7.88 (1H, dd), 8.48 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, d), 8.64 (1H, m) 
                   
               
               
                 P217 
                 6-chloro-3-pyridyl 
                 CF3 
                 4-Cl 
                 5.49 (2H, s), 6.85 (1H, dd), 7.35 (1H, 
                 m/z = 350 
               
               
                   
                   
                   
                   
                 d), 7.76 (1H, dd), 7.85 (1H, dd), 8.44 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, d), 8.62 (1H, s) 
                   
               
               
                 P218 
                 2-chloro-5-thiazolyl 
                 CF3 
                 5-Cl 
                 5.56 (2H, s), 7.68 (1H, s), 7.74 (1H, 
                 m/z = 356 
               
               
                   
                   
                   
                   
                 dd), 7.84 (1H, d), 8.58 (1H, d) 
                 (M + H) 
               
               
                 P219 
                 2-chloro-5-thiazolyl 
                 CF3 
                 5-F 
                 5.60 (2H, s), 7.69 (1H, s), 7.72 (1H, 
                 m/z = 340 
               
               
                   
                   
                   
                   
                 td), 7.86 (1H, m), 8.67 (1H, m) 
                 (M + H) 
               
               
                 P220 
                 2-chloro-5-thiazolyl 
                 CF3 
                 4-Cl 
                 5.58 (2H, s), 6.90 (1H, d), 7.67 (1H, 
                 m/z = 356 
               
               
                   
                   
                   
                   
                 s), 7.90 (1H, d), 8.61 (1H, s) 
                 (M + H) 
               
               
                 P221 
                 6-chloro-3-pyridyl 
                 CF3 
                 3-Me 
                 2.31 (3H, s), 5.50 (2H, s), 6.98 (1H, 
                 m/z = 330 
               
               
                   
                   
                   
                   
                 m), 7.34 (1H, d), 7.73 (1H, dd), 
                 (M + H) 
               
               
                   
                   
                   
                   
                 7.77 (2H, m), 8.42 (1H, d) 
                   
               
               
                 P222 
                 6-chloro-3-pyridyl 
                 CF3 
                 4-Me 
                 2.40 (3H, S), 5.49 (2H, s), 6.70 (1H, 
                 m/z = 330 
               
               
                   
                   
                   
                   
                 dd), 7.32 (1H, d), 7.70 (1H, d), 7.86 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, dd), 8.37 (1H, s), 8.43 (1H, d) 
                   
               
               
                 P223 
                 6-chloro-3-pyridyl 
                 CF3 
                 5-Me 
                 2.29 (3H, s), 5.52 (2H, s), 7.32 (1H, 
                 m/z = 330 
               
               
                   
                   
                   
                   
                 d), 7.62 (1H, s), 7.65 (1H, dd), 7.88 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, dd), 8.46 (1H, d), 8.50 (1H, d) 
                   
               
               
                 P224 
                 phenyl 
                 CF3 
                 H 
                 5.58 (2H, s), 6.81 (1H, m), 7.37 (4H, 
                 m/z = 281 
               
               
                   
                   
                   
                   
                 m), 7.77 (2H, m), 8.50 (1H, d) 
                 (M + H) 
               
               
                 P225 
                 4-chlorophenyl 
                 CF3 
                 H 
                 5.52 (2H, s), 6.85 (1H, m), 7.30 (2H, 
                 m/z = 315 
               
               
                   
                   
                   
                   
                 d), 7.36 (2H, d), 7.75 (1H, td), 7.84 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, d), 8.47 (1H, d) 
                   
               
               
                 P226 
                 3-pyridyl 
                 CF3 
                 H 
                 5.57 (2H, s), 6.86 (1H, m), 7.26-7.35 
                 m/z = 282 
               
               
                   
                   
                   
                   
                 (2H, m), 7.78 (1H, td), 7.86 (1H, m), 
                 (M + H) 
               
               
                   
                   
                   
                   
                 8.63 (2H, m), 8.67 (1H, d) 
                   
               
               
                 P227 
                 6-chloro-5-fluoro- 
                 CF3 
                 H 
                 5.54 (2H, s), 6.89 (1H, td), 7.76 (1H, 
                 m/z = 334 
               
               
                   
                 3-pyridyl 
                   
                   
                 dd), 7.80 (1H, td), 7.85 (1H, d), 8.29 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, d), 8.57 (1H, d) 
                   
               
               
                 P228 
                 6-trifluoromethyl- 
                 CF3 
                 H 
                 5.62 (2H, s), 6.90 (1H, t), 7.69 (1H, 
                 m/z = 350 
               
               
                   
                 3-pyridyl 
                   
                   
                 d), 7.81 (1H, t), 7.88 (1H, d), 8.06 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, d), 8.56 (1H, d), 8.78 (1H, s) 
                   
               
               
                 P229 
                 6-fluoro-3-pyridyl 
                 CF3 
                 H 
                 5.56 (2H, s), 6.89 (1H, td), 6.94 (1H, 
                 m/z = 300 
               
               
                   
                   
                   
                   
                 d), 7.79 (1H, td), 7.87 (1H, d), 8.03 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, m), 8.31 (1H, s), 8.54 (1H, d) 
                   
               
               
                 P230 
                 5,6-dichloro-3- 
                 CF3 
                 H 
                 5.49 (2H, s), 6.89 (1H, t), 7.79-7.90 
                 m/z = 350 
               
               
                   
                 pyridyl 
                   
                   
                 (2H, m), 8.04 (1H, d), 8.37 (1H, d), 
                 (M + H) 
               
               
                   
                   
                   
                   
                 8.56 (1H, m) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Compound 
                   
                   
                   
                   
                 IR (KBr, v, 
               
               
                 No. 
                 Ar 
                 R1a 
                 Y 
                   1 H-NMR (CDCl3, δ, ppm) 
                 cm −1 ) or MS 
               
               
                   
               
               
                 P231 
                 6-bromo-3-pyridyl 
                 CF3 
                 H 
                 5.52 (2H, s), 6.88 (1H, t), 7.48 (1H, d), 
                 m/z = 360 
               
               
                   
                   
                   
                   
                 7.78 (2H, m), 7.84 (1H, d), 8.44 (1H, 
                 (M + H) 
               
               
                   
                   
                   
                   
                 d), 8.53 (1H, d) 
                   
               
               
                 P232 
                 6-chloro-3-pyridyl 
                 CF3 
                 4-F 
                 5.52 (2H, s), 6.71 (1H, m), 7.35 (1H, 
                 m/z = 334 
               
               
                   
                   
                   
                   
                 d), 7.86 (1H, dd), 7.94 (1H, m), 8.33 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, dd), 8.44 (1H, d) 
                   
               
               
                 P233 
                 6-chloro-3-pyridyl 
                 CF3 
                 3-F 
                 5.53 (2H, s), 6.74 (1H, m), 7.33 (1H, 
                 m/z = 334 
               
               
                   
                   
                   
                   
                 d), 7.87 (1H, dd), 8.07 (1H, m), 8.29 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, dd), 8.45 (1H, d) 
                   
               
               
                 P234 
                 6-chloro-3-pyridyl 
                 CHCl2 
                 H 
                 5.54 (2H, s), 6.02 (1H, s), 6.77 (1H, t), 
                 m/z = 330 
               
               
                   
                   
                   
                   
                 7.32 (1H, m), 7.69 (1H, m), 7.77 (1H, 
                 (M + H) 
               
               
                   
                   
                   
                   
                 d), 7.89 (1H, m), 8.42 (1H, m), 8.49 
                   
               
               
                   
                   
                   
                   
                 (1H, s) 
                   
               
               
                 P235 
                 6-chloro-3-pyridyl 
                 CCl3 
                 H 
                 5.59 (2H, s), 6.86 (1H, t), 7.32 (1H, 
                 m/z = 364 
               
               
                   
                   
                   
                   
                 d), 7.78 (1H, td), 7.91 (2H, m), 8.43 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, d), 8.50 (1H, d) 
                   
               
               
                 P236 
                 6-chloro-3-pyridyl 
                 CH2Cl 
                 H 
                 4.17 (2H, s), 5.46 (2H, s), 6.64 (1H, 
                 m/z = 296 
               
               
                   
                   
                   
                   
                 td), 7.31 (1H, d), 7.60 (1H, td), 7.64 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, dd), 7.80 (1H, dd), 8.32 (1H, d), 
                   
               
               
                   
                   
                   
                   
                 8.45 (1H, d) 
                   
               
               
                 P238 
                 6-chloro-3-pyridyl 
                 CHF2 
                 H 
                 5.52 (2H, s), 5.90 (1H, t), 6.79 (1H, 
                 m/z = 298 
               
               
                   
                   
                   
                   
                 td), 7.33 (1H, d), 7.71 (1H, m), 7.77 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, dd), 7.85 (1H, dd), 8.45 (1H, d), 
                   
               
               
                   
                   
                   
                   
                 8.50 (1H, d) 
                   
               
               
                 P239 
                 6-chloro-3-pyridyl 
                 CF2Cl 
                 H 
                 5.56 (2H, s), 6.92 (1H, t), 7.33 (1H, d), 
                 m/z = 332 
               
               
                   
                   
                   
                   
                 7.82 (1H, m), 7.91 (1H, dd), 8.02 (1H, 
                 (M + H) 
               
               
                   
                   
                   
                   
                 d), 8.45 (1H, d), 8.48 (1H, d) 
                   
               
               
                 P240 
                 6-chloro-3-pyridyl 
                 CHClBr 
                 H 
                 5.53 (1H, d), 5.58 (1H, d), 6.06 (1H, 
                 m/z = 374 
               
               
                   
                   
                   
                   
                 s), 6.76 (1H, td), 7.32 (1H, d), 7.69 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, m), 7.70 (1H, m), 7.90 (1H, dd), 
                   
               
               
                   
                   
                   
                   
                 8.40 (1H, d), 8.50 (1H, d) 
                   
               
               
                 P241 
                 6-chloro-3-pyridyl 
                 CHBr2 
                 H 
                 5.56 (2H, s), 5.99 (1H, s), 6.78 (1H, 
                 m/z = 418 
               
               
                   
                   
                   
                   
                 td), 7.33 (1H, d), 7.69 (1H, td), 7.76 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, dd), 7.93 (1H, dd), 8.39 (1H, d), 
                   
               
               
                   
                   
                   
                   
                 8.50 (1H, d) 
                   
               
               
                 P242 
                 6-chloro-3-pyridyl 
                 CF2CF3 
                 H 
                 5.56 (2H, s), 6.90 (1H, td), 7.32 (1H, 
                 m/z = 366 
               
               
                   
                   
                   
                   
                 d), 7.79 (2H, m), 7.84 (1H, d), 8.43 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (1H, d), 8.56 (1H, d) 
                   
               
               
                 P243 
                 2-chloro-5- 
                 CF3 
                 H 
                 5.54 (2H, s), 6.98 (1H, m), 7.87 (1H, 
                 m/z = 317 
               
               
                   
                 pyrimidinyl 
                   
                   
                 m), 8.18 (1H, m), 8.48 (1H, m), 8.83 
                 (M + H) 
               
               
                   
                   
                   
                   
                 (2H, m) 
                   
               
               
                 P244 
                 6-chloro-3-pyridyl 
                 CH2Br 
                 H 
                 4.17 (2H, s), 5.46 (2H, s), 6.63 (1H, 
                   
               
               
                   
                   
                   
                   
                 td), 7.31 (1H, d), 7.60 (1H, td), 7.65 
                   
               
               
                   
                   
                   
                   
                 (1H, dd), 7.80 (1H, dd), 8.32 (1H, d), 
                   
               
               
                   
                   
                   
                   
                 8.47 (1H, d) 
               
               
                   
               
            
           
         
       
     
     (2) a nitrogen-containing heterocyclic derivative or a salt thereof having a 2-imino group represented by Formula (I) in (1), wherein Ar in Formula (I) is a 6-chloro-3-pyridyl group, a 6-chloro-5-fluoro-3-pyridyl group, a 6-fluoro-3-pyridyl group, a 6-bromo-3-pyridyl group, a 2-chloro-5-pyrimidinyl group, a 2-chloro-5-thiazolyl group, or a 5-chloro-2-pyradinyl group, 
     (3) a nitrogen-containing heterocyclic derivative or a salt thereof having a 2-imino group indicated in either (1) or (2) in the above, wherein A in the formula (I) is equivalent to formula (A-1) in (1), Y being a hydrogen atom, a halogen atom, or a cyano group, 
     (4) a nitrogen-containing heterocyclic derivative or a salt thereof having a 2-imino group indicated in any of (1) to (3) in the above, wherein R in the formula (I) is a (c) group of the following formula: 
     
       
         
         
             
             
         
       
     
     (5) a nitrogen-containing heterocyclic derivative or a salt thereof having a 2-imino group indicated in any of (1) to (3) in the above, wherein R in the formula (I) is an (a) group of the following formula: 
     
       
         
         
             
             
         
       
     
     (6) a nitrogen-containing heterocyclic derivative having a 2-imino group or a salt thereof according to any one of (1) to (3), wherein R in the Formula (I) is a group of Formula (d): 
     
       
         
         
             
             
         
       
     
     in which R 4  is a C1 to C18 alkyl group which may be substituted, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a substituted or unsubstituted (C6 to C10) aryl group, a substituted or unsubstituted (C6 to C10) aryl (C1 to C6) alkyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkenyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkynyl group, a substituted or unsubstituted phenoxy (C1 to C6) alkyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkenyl group, a substituted or unsubstituted phenoxy (C2 to C6) alkynyl group, a substituted or unsubstituted 5- to 10-membered heterocycle, a substituted or unsubstituted 5- to 10-membered heterocycle (C1 to C6) alkyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkenyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkynyl group, a (C1 to C4) alkoxy (C1 to C5) alkyl group, a (C1 to C4) alkoxy (C2 to C5) alkenyl group, a (C1 to C4) alkoxy (C2 to C5) alkynyl group, a (C1 to C4) alkylthio (C1 to C5) alkyl group, a (C1 to C4) alkylthio (C2 to C5) alkenyl group, a (C1 to C4) alkylthio (C2 to C5) alkynyl group, and R5 is a C1 to C6 alkyl group which may be substituted with a halogen atom, a C2 to C6 alkenyl group which may be substituted with a halogen atom, or a C2 to C6 alkynyl group which may be substituted with a halogen atom, 
     (7) a nitrogen-containing heterocyclic derivative or a salt thereof having a 2-imino group indicated in (1) in the above, the 2-imino group being N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroethanthioamide, 
     (8) a pest control agent including a nitrogen-containing heterocyclic derivative having a 2-imino group, which is described in any one of (1) to (7) or salts thereof, 
     (9) a method for controlling pests, using a nitrogen-containing heterocyclic derivative having a 2-imino group, which is described in any one of (1) to (7) or salts thereof, or a pest control agent described in (8), 
     (10) a method for controlling pests, including: treating seeds, roots, tubers, bulbs and rhizomes of plants, soil, a nutrient solution in nutrient solution culture, a solid medium in nutrient solution culture or a simple body that grows plants with a nitrogen-containing heterocyclic derivative having a 2-imino group, which is described in any one of (1) to (7) or salts thereof, or a pest control agent described in (8) to penetrate and migrate the compound into the plants, 
     (11) a method described in (9) or (10), in which the pest is an agricultural and horticultural pest, 
     (12) a method described in (9), in which the pest is an animal parasitic pest, 
     (13) a method described in (9) to (12), in which the pest is a drug-resistant pest, 
     (14) a method for preparing a compound represented by Formula (I-3) [in the formula, Ar, A, Y and R3 have the same meaning as those defined as Formula (I) in (1)], 
     
       
         
         
             
             
         
       
     
     in which a reaction of converting an oxygen atom in the compound represented by Formula (II-3a) [in the formula, Ar, A, Y and R3 have the same meaning as those defined as Formula (I) in (1)] or 
     
       
         
         
             
             
         
       
     
     Formula (II-3c) [in the formula, A, Y and R3 have the same meaning as those defined as Formula (I) in (1)] 
     
       
         
         
             
             
         
       
     
     into a sulfur atom is performed, and 
     (15) a method for preparing a compound represented by Formula (I-4) (in which Ar, A, Y, R 4  and R 5  are defined as in Formula (I) of (1)): 
     
       
         
         
             
             
         
       
     
     wherein a compound represented by Formula (II-4a): 
     
       
         
         
             
             
         
       
     
     (in which Ar, A, Y and R 5  are defined as in Formula (I) of (1)) is reacted with a compound represented by R 4 —NH 2  (in which R 4  is defined as in Formula (I) of (1)). 
     Advantageous Effects of Invention 
     It is possible to effectively perform pest control against cabbage moths,  Spodoptera litura , aphids, planthoppers, leafhoppers,  thrips  and other numerous pests by using the nitrogen-containing heterocyclic derivative having a 2-imino group of the present invention. 
    
    
     DESCRIPTION OF EMBODIMENTS 
     In a nitrogen-containing heterocyclic derivative having a 2-imino group denoted in the formula (I) provided in the present invention, examples of a substituent that may be substituted with “a phenyl group which may be substituted” and “a 5- to 6-membered heterocycle which may be substituted”, which are represented by Ar, include a halogen atom, a C1 to C4 alkyl group which may be substituted with a halogen atom, a C1 to C4 alkyloxy group which may be substituted with a halogen atom, a hydroxyl group, a cyano group, a nitro group and the like, preferably a halogen atom, a trifluoromethyl group and a cyano group, and particularly preferably a halogen atom. 
     Specific examples of the “a phenyl group which may be substituted” represented by Ar of a nitrogen-containing heterocyclic derivative compound having a 2-imino group represented by Formula (I) include a phenyl group and a 3-cyano phenyl group. 
     “A 5- to 6-membered heterocycle which may be substituted”, represented by Ar of a nitrogen-containing heterocyclic derivative compound having a 2-imino group represented by Formula (I) represents an aromatic 5- to 6-membered heterocycle including one or two of a heteroatom such as an oxygen atom, a sulfur atom or a nitrogen atom, specific examples thereof include a pyridine ring, a pyrazine ring, a pyrimidine ring, a pyridazine ring, a thiazole ring, an oxazole ring and the like, and preferable aspects thereof include a 6-chloro-3-pyridyl group, a 6-chloro-5-fluoro-3-pyridyl group, a 6-bromo-3-pyridyl group, a 6-fluoro-3-pyridyl group, a 6-trifluoromethyl-3-pyridyl group, a 6-chloro-3-pyridazinyl group, a 5-chloro-2-pyrazinyl group, a 2-chloro-5-pyrimidinyl group, a 2-chloro-5-thiazolyl group, a 2-chloro-4-pyridyl group, and more preferably a 6-chloro-3-pyridyl group, a 6-fluoro-3-pyridyl group, a 6-chloro-5-fluoro-3-pyridyl group, a 6-bromo-3-pyridyl group and a 2-chloro-5-pyrimidinyl group. 
     Specific examples of “a 4- to 10-membered heterocycloalkyl group” represented by Ar of a nitrogen-containing hetero ring derivative having a 2-imino group represented by Formula (I) include a 2-tetrahydrofuranyl group, a 3-tetrahydrofuranyl group and the like and preferably a 3-tetrahydrofuranyl group. 
     “A heterocycle having a 5- to 10-membered unsaturated bond including one or more nitrogen atoms”, which A of a nitrogen-containing heterocyclic derivative having a 2-imino group, which is represented by Formula (I), represents, means 
     
       
         
         
             
             
         
       
     
     in Formula (I), but represents any one ring represented by the following Formulas A-1 to A-40. In each formula, the end of a double bond is the substitution position of a nitrogen atom. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     The ring is preferably the ring of Formulas A-1, A-13, A-14, A-15, A-16, A-23, A-25, A-38 and A-39 and more preferably the ring of Formula A-1. 
     “A C1 to C6 alkyl group which may be substituted with a halogen atom”, which Y of the nitrogen-containing heterocyclic derivative having a 2-imino group, which is represented by Formula (I), represents, is a C1 to C6 alkyl group, which is chained, branched, cyclic or combination thereof, and the upper limit of the number of halogen atoms which may be substituted is the number of hydrogen atoms which the alkyl group has. When a branched or cyclic alkyl group is included, it is obvious that the number of carbons is 3 or more. 
     Specific examples of “a C1 to C6 alkyloxy group which may be substituted with a halogen atom” which Y represents include a methoxy group, an ethoxy group, a trifluoromethyloxy group and a difluoromethyloxy group. 
     A preferred aspect of Y is preferably a hydrogen atom or a halogen atom and more preferably a hydrogen atom. 
     In Formula (I), when R represents a Formula (a) group, “a substituted C1 to C6 alkyl group” which R1 represents is an alkyl group having 1 to 6 carbon atoms, which is chained, branched, cyclic or combination thereof, and the upper limit of the number of substituted substituents is the number of hydrogen atoms which the alkyl group has. Examples of the substituent include a halogen atom, a hydroxyl group, a cyano group, a nitro group, a phenyl group (this phenyl group may be substituted with a C1 to C4 alkyl group which may be substituted with a halogen, a C1 to C4 alkyloxy group which may be substituted with a halogen, a hydroxyl group, or a halogen atom), a phenoxy group (this phenoxy group may be substituted with a C1 to C4 alkyl group which may be substituted with a halogen, a C1 to C4 alkyloxy group which may be substituted with a halogen, a hydroxyl group, or a halogen atom), a benzyloxy group (the phenyl group in this benzyloxy group may be substituted with a C1 to C4 alkyl group which may be substituted with a halogen, a C1 to C4 alkyloxy group which may be substituted with a halogen, a hydroxyl group, or a halogen atom), and the like. Specific examples of the substituent include a trifluoromethyl group, a trichloromethyl group, a difluorochloromethyl group, a difluoromethyl group, a dichloromethyl group, a dibromomethyl group, a chloromethyl group, a difluoroethyl group, a dichloroethyl group, a 2,2,2-trifluoroethyl group, a pentafluoroethyl group, a difluorocyclopropyl group, a 2-cyanoethyl group, and a 2-nitroethyl group, and the like. Preferably, the C1-C6 alkyl group is a 2,2,2-trifluoroethyl group, a trifluoromethyl group, a difluorochloromethyl group, a difluoromethyl group, and a pentafluoroethyl group, and more preferably, the substituent is a trifluoromethyl group, a difluorochloromethyl group, a difluoromethyl group, and a pentafluoroethyl group, and particularly, a trifluoromethyl group. 
     In Formula (I), “a C1 to C6 alkyl group which may be substituted with a halogen atom”, which R3 when R represents a Formula (c) group, R5 when R represents a Formula (d) group, R7 when R represents a Formula (e) group, Ry when R represents a Formula (y), and Rz when R represents a Formula (z) each represent, is an alkyl group having 1 to 6 carbon atoms, which is chained, branched, cyclic or combination thereof, and the upper limit of the number of substituted halogen atoms is the number of hydrogen atoms which the alkyl group has. When a branched or cyclic alkyl group is included, it is obvious that the number of carbons is 3 or more. Specific examples of the C1-C6 alkyl group include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, a t-butyl group, a cyclopropyl group, a cyclopentyl group, a cyclohexyl group, a trifluoromethyl group, a trichloromethyl group, a difluorochloromethyl group, a difluoromethyl group, a dichloromethyl group, a dibromomethyl group, a chloromethyl group, a difluoroethyl group, a dichloroethyl group, a 2,2,2-trifluoroethyl group, a pentafluoroethyl group, a difluorocyclopropyl group, a trifluoroisopropyl group, and a hexafluoroisopropyl group, and the like. 
     R3 is, preferably, an ethyl group, an isopropyl group, a cyclopropyl group, a trifluoromethyl group, a difluorochloromethyl group, a difluoromethyl group, and a pentafluoroethyl group, more preferably, a trifluoromethyl group, a difluorochloromethyl group, a difluoromethyl group, and a pentafluoroethyl group, and particularly preferably, a trifluoromethyl group. R5 is, preferably, a trifluoromethyl group, a trichloromethyl group, a dichloromethyl group, a difluoromethyl group, a difluorochloromethyl group, a chloromethyl group, and a pentafluoroethyl group, more preferably, a trifluoromethyl group, a difluoromethyl group, a difluorochloromethyl group, a pentafluoroethyl group, and particularly preferably, a trifluoromethyl group. R7 is, preferably, a trifluoromethyl group, a trichloromethyl group, a dichloromethyl group, a difluoromethyl group, a difluorochloromethyl group, a chloromethyl group, and a pentafluoroethyl group, more preferably, a trifluoromethyl group, a difluoromethyl group, a difluorochloromethyl group, and a pentafluoroethyl group, and particularly preferably, a trifluoromethyl group. 
     Ry is preferably a methyl group, ethyl group, propyl group or isopropyl group. Rz is preferably a methyl group or trifluoromethyl group. 
     In Formula (I), when R represents a Formula (b) group, “a C1 to C6 alkyl group which is substituted with a halogen atom” which R2 represents is an alkyl group having 1 to 6 carbon atoms, which is chained, branched, cyclic or combination thereof, and the upper limit of the number of substituted halogen atoms is the number of hydrogen atoms which the alkyl group has. When a branched or cyclic alkyl group is included, it is obvious that the number of carbons is 3 or more. Specific examples of the C1-C6 alkyl group includes a trifluoromethyl group, a trichloromethyl group, a difluorochloromethyl group, a difluoromethyl group, a dichloromethyl group, a dibromomethyl group, a chloromethyl group, a difluoroethyl group, a dichloroethyl group, a 2,2,2-trifluoroethyl group, a 1-(trifluoromethyl)ethyl group, a 1-trifluoromethyl-2,2,2-trifluoroethyl group, a pentafluoroethyl group, and a difluorocyclopropyl group, and the like, and preferably, the alkyl group is a 2,2,2-trifluoroethyl group, a 1-(trifluoromethyl)ethyl group, a 1-trifluoromethyl-2,2,2-trifluoroethyl group, a pentafluoroethyl group, and a difluorocyclopropyl group, and the like, and preferably, the alkyl group is a 2,2,2-trifluoroethyl group, a 1-(trifluoromethyl)ethyl group, and a 1-trifluoromethyl-2,2,2-trifluoroethyl group. 
     In Formula (I), “a C1 to C18 alkyl group which may be substituted”, which R4 when R represents a Formula (d) group and R6 when R represents a Formula (e) group represent, is an alkyl group having 1 to 18 carbon atoms, which is chained, branched, cyclic or combination thereof, and the upper limit of the number of substituents which may be substituted is the number of hydrogen atoms which the alkyl group has. When a branched or cyclic alkyl group is included, it is obvious that the number of carbons is 3 or more. Examples of the substituent which may be substituted with C1-C18 alkyl group include a halogen atom, a hydroxyl group, a cyano group, and a nitro group. Specific examples of C1-C18 alkyl group include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an s-butyl group, a t-butyl group, a 3-methyl-2-butyl group, a 3-pentyl group, a 4-heptyl group, a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group, an n-octyl group, an n-tridecyl group, an n-hexadecyl group, an n-octadecyl group, a trifluoromethyl group, a trichloromethyl group, a difluorochloromethyl group, a difluoromethyl group, a dichloromethyl group, a dibromomethyl group, a chloromethyl group, a difluoroethyl group, a dichloroethyl group, a 2,2,2-trifluoroethyl group, a pentafluoroethyl group, a difluorocyclopropyl group, a 2-hydroxyethyl group, a 2-hydroxy-n-propyl group, a 3-hydroxy-n-propyl group, a 2,3-dihydroxy-n-propyl group, a cyanomethyl group, a 2-cyanoethyl group, and a 2-nitroethyl group, and the like. 
     R4 is, preferably, a methyl group, an ethyl group, a 2,2,2-trifluoroethyl group, a 2,2-difluoroethyl group, an n-propyl group, an isopropyl group, a cyclopropyl group, a t-butyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group, and a 2-hydroxyethyl group, and more preferably, a methyl group, an ethyl group, an isopropyl group, an n-butyl group, a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, and a cyclohexyl group. R6 is, preferably, a methyl group, an ethyl group, an isopropyl group, a cyclopropyl group, a t-butyl group, and a cyanomethyl group, and more preferably, a methyl group, an ethyl group, a cyclopropyl group, and a t-butyl group. 
     In Formula (I), “a C1 to C6 alkyl group which may be substituted with a halogen atom”, which R4a when R represents a Formula (f) group, R4b when R represents a Formula (g) group, R4c when R represents a Formula (h) group, R6a when R represents a Formula (o) group, R6b when R represents a Formula (p) group, R6c when R represents a Formula (q) group, R4d when R represents a Formula (i), (j), (k) or (1) group, R4e and R4f when R represents Formulas (m) and (n) groups, R6d when R represents a Formula (r), (s), (t) or (u) group, R6e and R6f when R represents a Formula (v) group, R6g and R6h when R represents a Formula (w) group, and R6i, R6j and R6k when R represents a Formula (x) group represent, is an alkyl group having 1 to 6 carbon atoms, which is chained, branched, cyclic or combination thereof, and the upper limit of the number of substituted halogen atoms is the number of hydrogen atoms which the alkyl group has. When a branched or cyclic alkyl group is included, it is obvious that the number of carbons is 3 or more. Specific examples of the C1-C6 alkyl group include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, a t-butyl group, a cyclopropyl group, a cyclopentyl group, a cyclohexyl group, a trifluoromethyl group, a trichloromethyl group, a difluorochloromethyl group, a difluoromethyl group, a dichloromethyl group, a dibromomethyl group, a chloromethyl group, a difluoroethyl group, a 2-chloroethyl group, a dichloroethyl group, a 2,2,2-trifluoroethyl group, a pentafluoroethyl group, and a difluorocyclopropyl group, and the like. R6a is, preferably, a methyl group, an ethyl group, an isopropyl group, and a cyclopropyl group. R6b is, preferably, a methyl group. 
     “A C2 to C6 alkenyl group which may be substituted with a halogen atom”, which R1, R2, R3, R4, R4a, R4b, R4c, R5, R6, R6a, R6b, R6c, R7, R4d, R4e, R4f, R6d, R6e, R6f, R6g, R6h, R6i, R6j, R6k, Ry and Rz represent, is an alkenyl group having 2 to 6 carbon atoms, which is chained, branched, cyclic or combination thereof, and the upper limit of the number of substituted halogen atoms is the number of hydrogen atoms which the alkenyl group has. When a branched or cyclic alkenyl group is included, it is obvious that the number of carbons is 3 or more. Specifically, the C2-C6 alkenyl group is an ethenyl group, a 1-propenyl group, a 2-propenyl group, a 2-fluoro-1-propenyl group, a 2-methyl-1-propenyl group, and the like. R6 is, preferably, a 2-propenyl group, and R6a is, preferably, an ethenyl group. 
     “A C2 to C6 alkynyl group which may be substituted with a halogen atom”, which R1, R2, R3, R4, R4a, R4b, R4c, R5, R6, R6a, R6b, R6c, R7, R4d, R4e, R4f, R6d, R6e, R6f, R6g, R6h, R6i, R6j, R6k, Ry and Rz represent, is an alkynyl group having 2 to 6 carbon atoms, which is chained, branched or combination thereof, and the upper limit of the number of substituted halogen atoms is the number of hydrogen atoms which the alkynyl group has. When a branched or cyclic alkynyl group is included, it is obvious that the number of carbons is 3 or more. Specific examples thereof include a 1-propynyl group, a 2-propynyl group, a 1-butynyl group, a 2-butynyl group, a 1-pentynyl group, a 2-pentynyl group, a 3-pentynyl group and the like, and preferred examples thereof include a 1-propynyl group, a 2-propynyl group and a 2-butynyl group. 
     The (C6 to C10) aryl of “a substituted or unsubstituted (C6 to C10) aryl group, a substituted or unsubstituted (C6 to C10) aryl (C1 to C6) alkyl group, a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkenyl group and a substituted or unsubstituted (C6 to C10) aryl (C2 to C6) alkynyl group”, which R2, R3, R4, R4a, R4b, R4c, R5, R6, R6a, R6b, R6c, R7, Ry and Rz represent, specifically represents a phenyl group and a naphthyl group, and the (C1 to C6) alkyl group, the (C2 to C6) alkenyl group and the (C2 to C6) alkynyl group may have a straight chain, branch or ring. Examples of the substituent which may be substituted with an aryl group include a halogen atom, a C1 to C4 alkyl group which may be substituted with halogen, a C1 to C4 alkyloxy group which may be substituted with halogen, a C3 to C6 cyclic alkyl group, a methylsulfonyl group, a methoxy group, a nitro group, a cyano group and the like. Specific examples of the (C6-C10) aryl include a phenyl group, a benzyl group, a 2-phenylethyl group, a 2-phenylethenyl group, a 2-phenylethynyl group, a 4-methylphenyl group, a 2-cyanophenyl group, a 3-chlorophenyl group, a 4-methoxyphenyl group, and a 3-cyanophenyl group, a 1,1-diphenylmethyl group, a naphthylethyl group, a naphthylpropyl group, and the like, and preferably, a benzyl group, a 2-phenylethyl group, a naphthylethyl group, and a naphthylpropynyl group. 
     The (C1 to C6) alkyl group, (C2 to C6) alkenyl group and (C2 to C6) alkynyl group of “a substituted or unsubstituted phenoxy group (C1 to C6) alkyl group, a substituted or unsubstituted phenoxy group (C2 to C6) alkenyl group and a substituted or unsubstituted phenoxy group (C2 to C6) alkynyl group”, which R3, R4, R4a, R4b, R4c, R5, R6, R6a, R6b, R6c, R7, Ry and Rz represent, may have a straight chain, branch or ring. Examples of the substituent which may be substituted with a phenoxy group include a halogen atom, a C1 to C4 alkyl group which may be substituted with halogen, a C1 to C4 alkyloxy group which may be substituted with halogen, a C3 to C6 cyclic alkyl group, a methylsulfonyl group, a methoxy group, a nitro group, a cyano group and the like. Specific examples of the (C1 to C6) alkyl group, a (C2 to C6) alkenyl group, and the (C2 to C6) alkynyl group include a phenoxy group, a phenoxymethyl group, a 2-phenoxyethyl group, a 2-phenoxyethenyl group, a 2-phenoxyethynyl group, a 4-chlorophenoxy group, and a 2-methylphenoxy group, and the like, and preferably, a 2-phenoxyethyl group. 
     The 5- to 10-membered heterocycle of “a substituted or unsubstituted 5- to 10-membered heterocycle, a substituted or unsubstituted 5- to 10-membered heterocycle (C1 to C6) alkyl group, a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkenyl group and a substituted or unsubstituted 5- to 10-membered heterocycle (C2 to C6) alkynyl group”, which R2, R3, R4, R4a, R4b, R4c, R5, R6, R6a, R6b, R6c, R7, Ry and Rz represent, represents a ring including one to four heteroatoms such as an oxygen atom, a sulfur atom or a nitrogen atom and the like as an atom constituting the ring, and examples thereof include a furanyl group, a thienyl group, a pyridyl group, a pyrrolidinyl group, a piperidinyl group, a piperazinyl group, a pyrimidinyl group, a morpholinyl group, a thiazolyl group, an imidazolyl group, a triazolyl group, a tetrahydrofuranyl group, a quinolinyl group and the like. Examples of the substituent which may be substituted with a heterocycle include a halogen atom, a C1 to C4 alkyl group which may be substituted with halogen, a C1 to C4 alkyloxy group which may be substituted with halogen, a C3 to C6 cyclic alkyl group, a methylsulfonyl group, a methoxy group, a nitro group, a cyano group and the like. The (C1 to C6) alkyl group, (C2 to C6) alkenyl group and (C2 to C6) alkenyl group may have a straight chain, branch or ring. Specifically, the 5- to 10-membered heterocycle is a 2-pyridyl group, a 3-pyridyl group, a 4-pyridyl group, a 2-pyridylmethyl group, a 3-pyridylmethyl group, a 4-pyridylmethyl group, a 2-(4-pyridyl)ethenyl group, a 2-(4-pyridyl)ethynyl group, a 2-furanylmethyl group, a 2-thienylmethyl group, a 2-tetrahydrofuranylmethyl group, and the like, and R4 is, preferably, a 2-pyridylmethyl group, a 3-pyridylmethyl group, a 4-pyridylmethyl group, a 2-furanylmethyl group, a 2-thienylmethyl group, and a 2-tetrahydrofuranylmethyl group. 
     The (C1 to C4) alkoxy of “a (C1 to C4) alkoxy (C1 to C5) alkyl group, a (C1 to C4) alkoxy (C2 to C5) alkenyl group and a (C1 to C4) alkoxy (C2 to C5) alkynyl group”, which R3, R4, R4a, R4b, R4c, R5, R6, R6a, R6b, R6c, R7, R6e, R6f and Rz represent, represents a (C1 to C4) alkyloxy, alkenyloxy and alkynyloxy having a straight chain, branch or ring. Specific examples of the (C1 to C4) alkoxy includes a methoxymethyl group, a 2-methoxyethyl group, an ethoxymethyl group, a 2-ethoxyethyl group, a 3-methoxy-2-propenyl group, and a 3-methoxy-2-propynyl group, and the like, and R4 is, preferably, a 2-methoxyethyl group. 
     The (C1 to C4) alkylthio of “a (C1 to C4) alkylthio (C1 to C5) alkyl group, a (C1 to C4) alkylthio (C2 to C5) alkenyl group and a (C1 to C4) alkylthio (C2 to C5) alkynyl group”, which R3, R4, R4a, R4b, R4c, R5, R6, R6a, R6b, R6c, R7, R6e, R6f and Rz represent, represents a (C1 to C4) alkylthio, alkenylthio and alkynylthio having a straight chain, branch or ring. The (C1 to C4) alkylthio includes a methylthiomethyl group, a 2-methylthioethyl group, an ethylthiomethyl group, a 2-ethylthioethyl group, a 3-methylthio-2-propenyl group, and a 3-methylthio-2-propynyl group, and the like, and R4 is, preferably, a 2-methylthioethyl group. 
     The (C6 to C10) aryl group of “a substituted or unsubstituted (C6 to C10) aryl group”, which R4d, R4e, R4f, R6d, R6e, R6f, R6g, R6h, R6i, R6j and R6k represent, specifically represents a phenyl group and a naphthyl group, and the (C1 to C6) alkyl group, (C2 to C6) alkenyl group and (C2 to C6) alkynyl group may have a straight chain, branch or ring. Examples of the substituent which may be substituted with an aryl group include a halogen atom, a C1 to C4 alkyl group which may be substituted with halogen, a C1 to C4 alkyloxy group which may be substituted with halogen, a C3 to C6 cyclic alkyl group, a methylsulfonyl group, a methoxy group, a nitro group, a cyano group and the like. Specific examples of the (C6-C10) aryl include a phenyl group, a 2-methylphenyl group, a 3-methoxyphenyl group, a 4-nitrophenyl group, and a 4-cyanophenyl group. 
     The 5- to 10-membered heterocycle of “a substituted or unsubstituted 5- to 10-membered heterocycle”, which R4d, R4e, R4f, R6d, R6e, R6f, R6g and R6h represent, represents a ring including one to four heteroatoms such as an oxygen atom, a sulfur atom or a nitrogen atom and the like as an atom constituting the ring, and examples thereof include a furanyl group, a thienyl group, a pyridyl group, a pyrrolidinyl group, a piperidinyl group, a piperazinyl group, a pyrimidinyl group, a morpholinyl group, a thiazolyl group, an imidazolyl group, a triazolyl group, a tetrahydrofuranyl group, a quinolinyl group and the like. The substituent which may be substituted with a heterocycle includes a halogen atom, a C1 to C4 alkyl group which may be substituted with a halogen, a C1 to C4 alkyloxy group which may be substituted with a halogen, a C3 to C6 cyclic alkyl group, a methylsulphonyl group, a methoxy group, a nitro group, and a cyano group, and the like. Specific examples of the 5- to 10-membered heterocycle include a 2-pyridyl group, a 3-pyridyl group, a 4-pyridyl group, a 2-furanyl group, a 2-thienyl group, and a 2-tetrahydrofuranyl group, and the like. 
     As a preferred aspect of a compound represented by Formula (I), 
     R represents the following Formula (a) group 
     
       
         
         
             
             
         
       
     
     Ar represents a 6-chloro-3-pyridyl group, a 2-chloro-5-thiazolyl group, a 6-chloro-5-fluoro-3-pyridyl group, a 6-fluoro-3-pyridyl group, a 6-bromo-3-pyridyl group, a 2-chloro-5-pyrimidinyl group, a 6-trifluoromethyl-3-pyridyl group and a 2-chloro-5-pyrimidinyl group, 
     A represents a ring represented by A-1, A-13, A-14, A-15, A-16, A-23 and A-38, 
     Y represents a hydrogen atom and a 3-cyano group, and 
     R1 represents a trifluoromethyl group, a difluoromethyl group, a chlorodifluoromethyl group, a pentafluoroethyl group, a trifluoroethyl group, an ethenyl group and a 2-propynyl group. 
     As another preferred aspect of a compound represented by Formula (I), 
     R represents the following Formula (c) group 
     
       
         
         
             
             
         
       
     
     Ar represents a 6-chloro-3-pyridyl group, a 2-chloro-5-thiazolyl group, a 6-chloro-5-fluoro-3-pyridyl group, a 6-fluoro-3-pyridyl group, a 6-bromo-3-pyridyl group, a 2-chloro-5-pyrimidyl group and a 6-trifluoromethyl-3-pyridyl group, 
     A represents a ring represented by A-1, 
     Y represents a hydrogen atom, and 
     R3 represents a trifluoromethyl group, a difluoromethyl group, a chlorodifluoromethyl group and a pentafluoroethyl group. 
     As still another preferred aspect of a compound represented by Formula (I), 
     R represents the following Formula (d) group 
     
       
         
         
             
             
         
       
     
     Ar represents a 6-chloro-3-pyridyl group, a 6-chloro-5-fluoro-3-pyridyl group, a 6-fluoro-3-pyridyl group, a 6-bromo-3-pyridyl group and a 2-chloro-5-pyrimidyl group, 
     A represents a ring represented by A-1, 
     Y represents a hydrogen atom, 
     R4 represents a hydrogen atom, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, a cyclopropyl group, a cyclobutyl group, a cyclohexyl group, and a cyclopentyl group, and 
     R5 represents a trifluoromethyl group, a difluoromethyl group, a chlorodifluoromethyl group and a pentafluoroethyl group. 
     As still another preferred aspect of a compound represented by Formula (I), 
     R represents the following Formula (e) group 
     
       
         
         
             
             
         
       
     
     Ar represents a 6-chloro-3-pyridyl group, a 6-chloro-5-fluoro-3-pyridyl group, a 6-fluoro-3-pyridyl group, a 6-bromo-3-pyridyl group and a 2-chloro-5-pyrimidyl group, 
     A represents a ring represented by A-1, 
     Y represents a hydrogen atom, 
     R6 represents a hydrogen atom, a methyl group, an ethyl group, a 2-propenyl group, a methylcarbonyl group, a ethylcarbonyl group, a cyclopropylcarbonyl group, an ethenylcarbonyl group, 2-propylcarbonyl group, benzoyl group, 3-pyridylcarbonyl group, methyloxycarbonyl group, and a phenyloxycarbonyl group, and 
     R7 represents a trifluoromethyl group, a difluoromethyl group, a chlorodifluoromethyl group and a pentafluoroethyl group. 
     The nitrogen-containing heterocyclic derivative having a 2-imino group may be a hydrochloride salt, nitrate salt, sulfate salt, phosphate salt, acetate salt or other acid addition salt. 
     Specific examples of the compound represented by Formula (I) include compounds shown in the following Table A (Tables 3 to 21) and Table B (Tables 22 to 37). 
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Table 1 
                 1-5~1-710 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 represents a 
               
               
                   
                   
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Nos. (1 
               
               
                   
                   
                   
                   
                   
                 and 6) below of Table B 
               
               
                 Table 2 
                 2-1~2-710 
                 2-Chloro-5-thiazolyl 
                 A-1 
                 H 
                 represents a 
               
               
                   
                   
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 3 
                 3-2~3-710 
                 6-Fluoro-3-pyridyl 
                 A-1 
                 H 
                 represents a 
               
               
                   
                   
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Nos. (1 
               
               
                   
                   
                   
                   
                   
                 and 3) below of Table B 
               
               
                 Table 4 
                 4-2~4-710 
                 6-Bromo-3-pyridyl 
                 A-1 
                 H 
                 represents a 
               
               
                   
                   
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Nos. (1 
               
               
                   
                   
                   
                   
                   
                 and 3) below of Table B 
               
               
                 Table 5 
                 5-2~5-710 
                 6-Chloro-5-fluoro- 
                 A-1 
                 H 
                 represents a 
               
               
                   
                   
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 1 each row of Nos. (1 
               
               
                   
                   
                   
                   
                   
                 and 3) below of Table B 
               
               
                 Table 6 
                 6-2~6-710 
                 2-Chloro-5-pyrimidinyl 
                 A-1 
                 H 
                 represents a 
               
               
                   
                   
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Nos. (1 
               
               
                   
                   
                   
                   
                   
                 and 3) below of Table B 
               
               
                 Table 7 
                 7-1~7-710 
                 5-Chloropyrazin- 
                 A-1 
                 H 
                 represents a 
               
               
                   
                   
                 2-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 8 
                 8-1~8-710 
                 6-Chloropyridazin- 
                 A-1 
                 H 
                 represents a 
               
               
                   
                   
                 3-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 9 
                 9-1~9- 
                 2-Chloro-5-oxazolyl 
                 A-1 
                 H 
                 represents a 
               
               
                   
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 10-1~10- 
                 6-trifluoromethyl- 
                 A-1 
                 H 
                 represents a 
               
               
                 10 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 11-1~11- 
                 3-tetrahydrofuranyl 
                 A-1 
                 H 
                 represents a 
               
               
                 11 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 12-1~12- 
                 2-Chloro-4-pyridyl 
                 A-1 
                 H 
                 represents a 
               
               
                 12 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 13-1~13- 
                 3-Cyanophenyl 
                 A-1 
                 H 
                 represents a 
               
               
                 13 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 14-1~14- 
                 6-Chloro-3-pyridyl 
                 A-1 
                 3-F 
                 represents a 
               
               
                 14 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 15-1~15- 
                 2-Chloro-5-thiazolyl 
                 A-1 
                 3-F 
                 represents a 
               
               
                 15 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 16-1~16- 
                 6-Fluoro-3-pyridyI 
                 A-1 
                 3-F 
                 represents a 
               
               
                 16 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 17-1~17- 
                 6-Bromo-3-pyridyl 
                 A-1 
                 3-F 
                 represents a 
               
               
                 17 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 18-1~18- 
                 6-Chloro-5-fluoro- 
                 A-1 
                 3-F 
                 represents a 
               
               
                 18 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 19-1~19- 
                 2-Chloro-5-pyrimidinyl 
                 A-1 
                 3-F 
                 represents a 
               
               
                 19 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 20-1~20- 
                 5-Chloropyrazin- 
                 A-1 
                 3-F 
                 represents a 
               
               
                 20 
                 710 
                 2-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 21-1~21- 
                 6-Chloropyridazin- 
                 A-1 
                 3-F 
                 represents a 
               
               
                 21 
                 710 
                 3-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 22-1~22- 
                 2-Chloro-5-oxazolyl 
                 A-1 
                 3-F 
                 represents a 
               
               
                 22 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 23-1~23- 
                 6-trifluoromethyl- 
                 A-1 
                 3-F 
                 represents a 
               
               
                 23 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 24-1~24- 
                 3-tetrahydrofuranyl 
                 A-1 
                 3-F 
                 represents a 
               
               
                 24 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 25-1~25- 
                 6-Chloro-3-pyridyl 
                 A-1 
                 4-F 
                 represents a 
               
               
                 25 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 26-1~26- 
                 2-Chloro-5-thiazolyl 
                 A-1 
                 4-F 
                 represents a 
               
               
                 26 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 27-1~27- 
                 6-Fluoro-3-pyridyl 
                 A-1 
                 4-F 
                 represents a 
               
               
                 27 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 28-1~28- 
                 6-Bromo-3-pyridyl 
                 A-1 
                 4-F 
                 represents a 
               
               
                 28 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 29-1~29- 
                 6-Chloro-5-fluoro- 
                 A-1 
                 4-F 
                 represents a 
               
               
                 29 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 30-1~30- 
                 2-Chloro-5-pyrimidinyl 
                 A-1 
                 4-F 
                 represents a 
               
               
                 30 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 31-1~31- 
                 5-Chloropyrazin- 
                 A-1 
                 4-F 
                 represents a 
               
               
                 31 
                 710 
                 2-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 32-1~32- 
                 6-Chloropyridazin- 
                 A-1 
                 4-F 
                 represents a 
               
               
                 32 
                 710 
                 3-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Table 
                 33-1~33- 
                 2-Chloro-5-oxazolyl 
                 A-1 
                 4-F 
                 represents a 
               
               
                 33 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 34-1~34- 
                 6-trifluoromethyl- 
                 A-1 
                 4-F 
                 represents a 
               
               
                 34 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 35-1~35- 
                 3-tetrahydrofuranyl 
                 A-1 
                 4-F 
                 represents a 
               
               
                 35 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 36-1~36- 
                 6-Chloro-3-pyridyl 
                 A-1 
                 5-F 
                 represents a 
               
               
                 36 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 37-1~37- 
                 2-Chloro-5-thiazolyl 
                 A-1 
                 5-F 
                 represents a 
               
               
                 37 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 38-1~38- 
                 6-Fluoro-3-pyridyl 
                 A-1 
                 5-F 
                 represents a 
               
               
                 38 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 39-1~39- 
                 6-Bromo-3-pyridyl 
                 A-1 
                 5-F 
                 represents a 
               
               
                 39 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 40-1~40- 
                 6-Chloro-5-fluoro- 
                 A-1 
                 5-F 
                 represents a 
               
               
                 40 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 41-1~41- 
                 2-Chloro-5-pyrimidinyl 
                 A-1 
                 5-F 
                 represents a 
               
               
                 41 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 42-1~42- 
                 5-Chloropyrazin- 
                 A-1 
                 5-F 
                 represents a 
               
               
                 42 
                 710 
                 2-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 43-1~43- 
                 6-Chloropyridazin- 
                 A-1 
                 5-F 
                 represents a 
               
               
                 43 
                 710 
                 3-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 44-1~44- 
                 2-Chloro-5-oxazolyl 
                 A-1 
                 5-F 
                 represents a 
               
               
                 44 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 45-1~45- 
                 6-trifluoromethyl- 
                 A-1 
                 5-F 
                 represents a 
               
               
                 45 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 46-1~46- 
                 3-tetrahydrofuranyl 
                 A-1 
                 5-F 
                 represents a 
               
               
                 46 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 47-1~47- 
                 6-Chloro-3-pyridyl 
                 A-1 
                 6-F 
                 represents a 
               
               
                 47 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 48-1~48- 
                 2-Chloro-5-thiazolyl 
                 A-1 
                 6-F 
                 represents a 
               
               
                 48 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 49-1~49- 
                 6-Fluoro-3-pyridyl 
                 A-1 
                 6-F 
                 represents a 
               
               
                 49 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 50-1~50- 
                 6-Bromo-3-pyridyl 
                 A-1 
                 6-F 
                 represents a 
               
               
                 50 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 51-1~51- 
                 6-Chloro-5-fluoro- 
                 A-1 
                 6-F 
                 represents a 
               
               
                 51 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 52-1~52- 
                 2-Chloro-5-pyrimidinyl 
                 A-1 
                 6-F 
                 represents a 
               
               
                 52 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 53-1~53- 
                 5-Chloropyrazin- 
                 A-1 
                 6-F 
                 represents a 
               
               
                 53 
                 710 
                 2-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 54-1~54- 
                 6-Chloropyridazin- 
                 A-1 
                 6-F 
                 represents a 
               
               
                 54 
                 710 
                 3-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 55-1~55- 
                 2-Chloro-5-oxazolyl 
                 A-1 
                 6-F 
                 represents a 
               
               
                 55 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 56-1~56- 
                 6-trifluoromethyl- 
                 A-1 
                 6-F 
                 represents a 
               
               
                 56 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 57-1~57- 
                 3-tetrahydrofuranyl 
                 A-1 
                 6-F 
                 represents a 
               
               
                 57 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 58-1~58- 
                 6-Chloro-3-pyridyl 
                 A-1 
                 3- 
                 represents a 
               
               
                 58 
                 710 
                   
                   
                 Cl 
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 59-1~59- 
                 2-Chloro-5-thiazolyl 
                 A-1 
                 3- 
                 represents a 
               
               
                 59 
                 710 
                   
                   
                 Cl 
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 60-1~60- 
                 6-Fluoro-3-pyridyl 
                 A-1 
                 3- 
                 represents a 
               
               
                 60 
                 710 
                   
                   
                 Cl 
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 61-1~61- 
                 6-Bromo-3-pyridyl 
                 A-1 
                 3- 
                 represents a 
               
               
                 61 
                 710 
                   
                   
                 Cl 
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 62-1~62- 
                 6-Chloro-5-fluoro- 
                 A-1 
                 3- 
                 represents a 
               
               
                 62 
                 710 
                 3-pyridyl 
                   
                 Cl 
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 63-1~63- 
                 2-Chloro-5-pyrimidinyl 
                 A-1 
                 3- 
                 represents a 
               
               
                 63 
                 642 
                   
                   
                 Cl 
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 64-1~64- 
                 5-Chloropyrazin- 
                 A-1 
                 3- 
                 represents a 
               
               
                 64 
                 710 
                 2-yl 
                   
                 Cl 
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Table 
                 65- 
                 6- 
                 A-1 
                 3- 
                 represents a 
               
               
                 65 
                 1~65- 
                 Chloropyridazin- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 66- 
                 2-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 66 
                 1~66- 
                 oxazolyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 67- 
                 6- 
                 A-1 
                 3- 
                 represents a 
               
               
                 67 
                 1~67- 
                 trifluoromethyl- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 68- 
                 3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 68 
                 1~68- 
                 tetrahydro- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 furanyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 69- 
                 6-Chloro-3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 69 
                 1~69- 
                 pyridyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 70- 
                 2-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 70 
                 1~70- 
                 thiazolyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 71- 
                 6-Fluoro-3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 71 
                 1~71- 
                 pyridyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 72- 
                 6-Bromo-3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 72 
                 1~72- 
                 pyridyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 73- 
                 6-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 73 
                 1~73- 
                 fluoro-3- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 74- 
                 2-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 74 
                 1~74- 
                 pyrimidinyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 75- 
                 5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 75 
                 1~75- 
                 Chloropyrazin- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 2-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 76- 
                 6- 
                 A-1 
                 4- 
                 represents a 
               
               
                 76 
                 1~76- 
                 Chloropyridazin- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 77- 
                 2-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 77 
                 1~77- 
                 oxazolyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 78- 
                 6- 
                 A-1 
                 4- 
                 represents a 
               
               
                 78 
                 1~78- 
                 trifluoromethyl- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 3-pyridyI 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 79- 
                 3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 79 
                 1~79- 
                 tetrahydro- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 furanyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 80- 
                 6-Chloro-3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 80 
                 1~80- 
                 pyridyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 81- 
                 2-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 81 
                 1~81- 
                 thiazolyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 82- 
                 6-Fluoro-3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 82 
                 1~82- 
                 pyridyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 83- 
                 6-Bromo-3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 83 
                 1~83- 
                 pyridyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 84- 
                 6-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 84 
                 1~84- 
                 fluoro-3- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 85- 
                 2-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 85 
                 1~85- 
                 pyrimidinyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 86- 
                 5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 86 
                 1~86- 
                 Chloropyrazin- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 2-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 87- 
                 6- 
                 A-1 
                 5- 
                 represents a 
               
               
                 87 
                 1~87- 
                 Chloropyridazin- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 88- 
                 2-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 88 
                 1~88- 
                 oxazolyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 89- 
                 6- 
                 A-1 
                 5- 
                 represents a 
               
               
                 89 
                 1~89- 
                 trifluoromethyl- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 90- 
                 3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 90 
                 1~90- 
                 tetrahydro- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 furanyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 91- 
                 6-Chloro-3- 
                 A-1 
                 6- 
                 represents a 
               
               
                 91 
                 1~91- 
                 pyridyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 92- 
                 2-Chloro- 
                 A-1 
                 6- 
                 represents a 
               
               
                 92 
                 1~92- 
                 5-thiazolyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 93- 
                 6-Fluoro-3- 
                 A-1 
                 6-Cl 
                 represents a 
               
               
                 93 
                 1~93- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 94- 
                 6-Bromo-3- 
                 A-1 
                 6- 
                 represents a 
               
               
                 94 
                 1~94- 
                 pyridyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 95- 
                 6-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 95 
                 1~95- 
                 fluoro-3- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 96- 
                 2-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 96 
                 1~96- 
                 pyrimidinyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Table 
                 97- 
                 5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 97 
                 1~97- 
                 Chloropyrazin- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 2-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 98- 
                 6- 
                 A-1 
                 6- 
                 represents a 
               
               
                 98 
                 1~98- 
                 Chloropyridazin- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 99- 
                 2-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 99 
                 1~99- 
                 oxazolyl 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 100- 
                 6- 
                 A-1 
                 6- 
                 represents a 
               
               
                 100 
                 1~100- 
                 trifluoromethyl- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 101- 
                 3- 
                 A-1 
                 6- 
                 represents a 
               
               
                 101 
                 1~101- 
                 tetrahydro- 
                   
                 Cl 
                 combination of 
               
               
                   
                 710 
                 furanyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 102- 
                 6-Chloro-3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 102 
                 1~102- 
                 pyridyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 103- 
                 2-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 103 
                 1~103- 
                 thiazolyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 104- 
                 6-Fluoro-3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 104 
                 1~104- 
                 pyridyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 105- 
                 6-Bromo-3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 105 
                 1~105- 
                 pyridyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 106- 
                 6-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 106 
                 1~106- 
                 fluoro-3- 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 107- 
                 2-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 107 
                 1~107- 
                 pyrimidinyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 108- 
                 5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 108 
                 1~108- 
                 Chloropyrazin- 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                 2-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 109- 
                 6- 
                 A-1 
                 3- 
                 represents a 
               
               
                 109 
                 1~109- 
                 Chloropyridazin- 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 110- 
                 2-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 110 
                 1~110- 
                 oxazolyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 111- 
                 6- 
                 A-1 
                 3- 
                 represents a 
               
               
                 111 
                 1~111- 
                 trifluoromethyl- 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 112- 
                 3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 112 
                 1~112- 
                 tetrahydro- 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                 furanyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 113- 
                 6-Chloro-3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 113 
                 1~113- 
                 pyridyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 114- 
                 2-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 114 
                 1~114- 
                 thiazolyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 115- 
                 6-Fluoro-3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 115 
                 1~115- 
                 pyridyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 116- 
                 6-Bromo-3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 116 
                 1~116- 
                 pyridyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 117- 
                 6-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 117 
                 1~117- 
                 Fluoro-3- 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 118- 
                 2-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 118 
                 1~118- 
                 pyrimidinyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 119- 
                 5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 119 
                 1~119- 
                 Chloropyrazin- 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                 2-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 120- 
                 6- 
                 A-1 
                 4- 
                 represents a 
               
               
                 120 
                 1~120- 
                 Chloropyridazin- 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 121- 
                 2-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 121 
                 1~121- 
                 oxazolyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 122- 
                 6- 
                 A-1 
                 4- 
                 represents a 
               
               
                 122 
                 1~122- 
                 trifluoromethyl- 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 123- 
                 3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 123 
                 1~123- 
                 tetrahydro- 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                 furanyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 124- 
                 6-Chloro-3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 124 
                 1~124- 
                 pyridyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 125- 
                 2-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 125 
                 1~155- 
                 thiazolyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 126- 
                 6-Fluoro-3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 126 
                 1~126- 
                 pyridyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 127- 
                 6-Bromo-3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 127 
                 1~127- 
                 pyridyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 128- 
                 6-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 128 
                 1~128- 
                 fluoro-3- 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 7 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Table 
                 129- 
                 2-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 129 
                 1~129- 
                 pyrimidinyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 130- 
                 5-Chloro- 
                 A-1 
                 5- 
                 represents a 
               
               
                 130 
                 1~130- 
                 pyrazin-2-yl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 131- 
                 6-Chloro- 
                 A-1 
                 5- 
                 represents a 
               
               
                 131 
                 1~131- 
                 pyridazin-3-yl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 132- 
                 2-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 132 
                 1~132- 
                 oxazolyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 133- 
                 6-trifluoromethyl- 
                 A-1 
                 5- 
                 represents a 
               
               
                 133 
                 1~133- 
                 3-pyridyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 134- 
                 3-tetrahydro- 
                 A-1 
                 5- 
                 represents a 
               
               
                 134 
                 1~134- 
                 furanyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 135- 
                 6-Chloro- 
                 A-1 
                 6- 
                 represents a 
               
               
                 135 
                 1~135- 
                 3-pyridyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 136- 
                 2-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 136 
                 1~136- 
                 thiazolyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 137- 
                 6-Fluoro-3- 
                 A-1 
                 6- 
                 represents a 
               
               
                 137 
                 1~137- 
                 pyridyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 138- 
                 6-Bromo-3- 
                 A-1 
                 6- 
                 represents a 
               
               
                 138 
                 1~138- 
                 pyridyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 139- 
                 6-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 139 
                 1~139- 
                 fluoro-3- 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 140- 
                 2-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 140 
                 1~140- 
                 pyrimidinyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 141- 
                 5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 141 
                 1~141- 
                 Chloropyrazin- 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                 2-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 142- 
                 6- 
                 A-1 
                 6- 
                 represents a 
               
               
                 142 
                 1~142- 
                 Chloropyridazin- 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 143- 
                 2-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 143 
                 1~143- 
                 oxazolyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 144- 
                 6- 
                 A-1 
                 6- 
                 represents a 
               
               
                 144 
                 1~144- 
                 trifluoromethyl- 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 145- 
                 3-tetrahydro- 
                 A-1 
                 6- 
                 represents a 
               
               
                 145 
                 1~145- 
                 furanyl 
                   
                 CN 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 146- 
                 6-Chloro-3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 146 
                 1~146- 
                 pyridyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 147- 
                 2-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 147 
                 1~147- 
                 thiazolyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 148- 
                 6-Fluoro-3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 148 
                 1~148- 
                 pyridyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 149- 
                 6-Bromo-3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 149 
                 1~149- 
                 pyridyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 150- 
                 6-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 150 
                 1~150- 
                 Fluoro-3- 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 151- 
                 2-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 151 
                 1~151- 
                 pyrimidinyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 152- 
                 5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 152 
                 1~152- 
                 Chloropyrazin- 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                 2-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 153- 
                 6- 
                 A-1 
                 3- 
                 represents a 
               
               
                 153 
                 1~153- 
                 Chloropyridazin- 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 154- 
                 2-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 154 
                 1~154- 
                 oxazolyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 155- 
                 6- 
                 A-1 
                 3- 
                 represents a 
               
               
                 155 
                 1~155- 
                 trifluoromethyl- 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 156- 
                 3-tetrahydro- 
                 A-1 
                 3- 
                 represents a 
               
               
                 156 
                 1~156- 
                 furanyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 157- 
                 6-Chloro-3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 157 
                 1~157- 
                 pyridyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 158- 
                 2-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 158 
                 1~158- 
                 thiazolyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 159- 
                 6-Fluoro-3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 159 
                 1~159- 
                 pyridyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 160- 
                 6-Bromo-3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 160 
                 1~160- 
                 pyridyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 8 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Table 
                 161- 
                 6-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 161 
                 1~161- 
                 fluoro-3- 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 162- 
                 2-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 162 
                 1~162- 
                 pyrimidinyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 163- 
                 5-Chloro- 
                 A-1 
                 4- 
                 represents a 
               
               
                 163 
                 1~163- 
                 pyrazin-2-yl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 164- 
                 6-Chloro- 
                 A-1 
                 4- 
                 represents a 
               
               
                 164 
                 1~164- 
                 pyridazin-3-yl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 165- 
                 2-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 165 
                 1~165- 
                 oxazolyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 166- 
                 6- 
                 A-1 
                 4- 
                 represents a 
               
               
                 166 
                 1~166- 
                 trifluoromethyl- 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 167- 
                 3-tetrahydro- 
                 A-1 
                 4- 
                 represents a 
               
               
                 167 
                 1~167- 
                 furanyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 168- 
                 6-Chloro-3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 168 
                 1~168- 
                 pyridyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 169- 
                 2-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 169 
                 1~169- 
                 thiazolyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 170- 
                 6-Fluoro-3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 170 
                 1~170- 
                 pyridyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 171- 
                 6-Bromo-3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 171 
                 1~171- 
                 pyridyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 172- 
                 6-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 172 
                 1~172- 
                 fluoro-3- 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 173- 
                 2-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 173 
                 1~173- 
                 pyrimidinyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 174- 
                 5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 174 
                 1~174- 
                 Chloropyrazin- 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                 2-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 175- 
                 6- 
                 A-1 
                 5- 
                 represents a 
               
               
                 175 
                 1~175- 
                 Chloropyridazin- 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 176- 
                 2-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 176 
                 1~176- 
                 oxazolyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 177- 
                 6- 
                 A-1 
                 5- 
                 represents a 
               
               
                 177 
                 1~77- 
                 ftriluoromethyl- 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                 3-pyridyI 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 178- 
                 3-tetrahydro- 
                 A-1 
                 5- 
                 represents a 
               
               
                 178 
                 1~178- 
                 furanyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 179- 
                 6-Chloro-3- 
                 A-1 
                 6- 
                 represents a 
               
               
                 179 
                 1~179- 
                 pyridyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 180- 
                 2-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 180 
                 1~180- 
                 thiazolyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 181- 
                 6-Fluoro-3- 
                 A-1 
                 6- 
                 represents a 
               
               
                 181 
                 1~181- 
                 pyridyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 182- 
                 6-Bromo-3- 
                 A-1 
                 6- 
                 represents a 
               
               
                 182 
                 1~182- 
                 pyridyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 183- 
                 6-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 183 
                 1~183- 
                 fluoro-3- 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 184- 
                 2-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 184 
                 1~184- 
                 pyrimidinyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 185- 
                 5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 185 
                 1~185- 
                 Chloropyrazin- 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                 2-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 186- 
                 6- 
                 A-1 
                 6- 
                 represents a 
               
               
                 186 
                 1~186- 
                 Chloropyridazin- 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 187- 
                 2-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 187 
                 1~187- 
                 oxazolyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 188- 
                 6- 
                 A-1 
                 6- 
                 represents a 
               
               
                 188 
                 1~188- 
                 trifluoromethyl- 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 189- 
                 3-tetrahydro- 
                 A-1 
                 6- 
                 represents a 
               
               
                 189 
                 1~189- 
                 furanyl 
                   
                 OH 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 190- 
                 6-Chloro-3- 
                 A-13 
                 H 
                 represents a 
               
               
                 190 
                 1~190- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 191- 
                 2-Chloro-5- 
                 A-13 
                 H 
                 represents a 
               
               
                 191 
                 1~191- 
                 thiazolyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 192- 
                 6-Fluoro-3- 
                 A-13 
                 H 
                 represents a 
               
               
                 192 
                 1~192- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 9 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
               
               
                 Table 
                 193-1~193- 
                 6-Bromo-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 193 
                 710 
                   
                 13 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 194-1~194- 
                 6-Chloro-5-fluoro- 
                 A- 
                 H 
                 represents a 
               
               
                 194 
                 710 
                 3-pyridyl 
                 13 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 195-1~195- 
                 2-Chloro-5- 
                 A- 
                 H 
                 represents a 
               
               
                 195 
                 710 
                 pyrimidinyl 
                 13 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 196-1~196- 
                 5-Chloropyrazin- 
                 A- 
                 H 
                 represents a 
               
               
                 196 
                 710 
                 2-yl 
                 13 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 197-1~197- 
                 6-Chloropyridazin- 
                 A- 
                 H 
                 represents a 
               
               
                 197 
                 710 
                 3-yl 
                 13 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 198-1~198- 
                 2-Chloro-5-oxazolyl 
                 A- 
                 H 
                 represents a 
               
               
                 198 
                 710 
                   
                 13 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 199-1~199- 
                 6-trifluoromethyl- 
                 A- 
                 H 
                 represents a 
               
               
                 199 
                 710 
                 3-pyridyl 
                 13 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 200-1~200- 
                 3-tetrahydrofuranyl 
                 A- 
                 H 
                 represents a 
               
               
                 200 
                 710 
                   
                 13 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 201-1~201- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 201 
                 710 
                   
                 14 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 202-1~202- 
                 2-Chloro-5-thiazolyl 
                 A- 
                 H 
                 represents a 
               
               
                 202 
                 710 
                   
                 14 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 203-1~203- 
                 6-Fluoro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 203 
                 710 
                   
                 14 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 204-1~204- 
                 6-Bromo-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 204 
                 710 
                   
                 14 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 205-1~205- 
                 6-Chloro-5-fluoro- 
                 A- 
                 H 
                 represents a 
               
               
                 205 
                 710 
                 3-pyridyl 
                 14 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 206-1~206- 
                 2-Chloro-5- 
                 A- 
                 H 
                 represents a 
               
               
                 206 
                 710 
                 pyrimidinyl 
                 14 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 207-1~207- 
                 5-Chloropyrazin- 
                 A- 
                 H 
                 represents a 
               
               
                 207 
                 710 
                 2-yl 
                 14 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 208-1~208- 
                 6-Chloropyridazin- 
                 A- 
                 H 
                 represents a 
               
               
                 208 
                 710 
                 3-yl 
                 14 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 209-1~209- 
                 2-Chloro-5-oxazolyl 
                 A- 
                 H 
                 represents a 
               
               
                 209 
                 710 
                   
                 14 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 210-1~210- 
                 6-trifluoromethyl- 
                 A- 
                 H 
                 represents a 
               
               
                 210 
                 710 
                 3-pyridyl 
                 14 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 211-1~211- 
                 3-tetrahydrofuranyl 
                 A- 
                 H 
                 represents a 
               
               
                 211 
                 710 
                   
                 14 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 212-1~212- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 212 
                 710 
                   
                 15 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 213-1~213- 
                 2-Chloro-5-thiazolyl 
                 A- 
                 H 
                 represents a 
               
               
                 213 
                 710 
                   
                 15 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 214-1~214- 
                 6-Fluoro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 214 
                 710 
                   
                 15 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 215-1~215- 
                 6-Bromo-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 215 
                 710 
                   
                 15 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 216-1~216- 
                 6-Chloro-5-fluoro- 
                 A- 
                 H 
                 represents a 
               
               
                 216 
                 710 
                 3-pyridyl 
                 15 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 217-1~217- 
                 2-Chloro-5- 
                 A- 
                 H 
                 represents a 
               
               
                 217 
                 710 
                 pyrimidinyl 
                 15 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 218-1~218- 
                 5-Chloropyrazin- 
                 A- 
                 H 
                 represents a 
               
               
                 218 
                 710 
                 2-yl 
                 15 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 219-1~219- 
                 6-Chloropyridazin- 
                 A- 
                 H 
                 represents a 
               
               
                 219 
                 710 
                 3-yl 
                 15 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 220-1~220- 
                 2-Chloro-5-oxazolyl 
                 A- 
                 H 
                 represents a 
               
               
                 220 
                 710 
                   
                 15 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 221-1~221- 
                 6-trifluoromethyl- 
                 A- 
                 H 
                 represents a 
               
               
                 221 
                 710 
                 3-pyridyl 
                 15 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 222-1~222- 
                 3-tetrahydrofuranyl 
                 A- 
                 H 
                 represents a 
               
               
                 222 
                 710 
                   
                 15 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 223-1~223- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 223 
                 710 
                   
                 16 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 224-1~224- 
                 2-Chloro-5-thiazolyl 
                 A- 
                 H 
                 represents a 
               
               
                 224 
                 710 
                   
                 16 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 10 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
               
               
                 Table 
                 225-1~225- 
                 6-Fluoro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 225 
                 710 
                   
                 16 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 226-1~226- 
                 6-Bromo-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 226 
                 710 
                   
                 16 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 227-1~227- 
                 6-Chloro-5-fluoro- 
                 A- 
                 H 
                 represents a 
               
               
                 227 
                 710 
                 3-pyridyl 
                 16 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 228-1~228- 
                 2-Chloro-5- 
                 A- 
                 H 
                 represents a 
               
               
                 228 
                 710 
                 pyrimidinyl 
                 16 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 229-1~229- 
                 5-Chloropyrazin- 
                 A- 
                 H 
                 represents a 
               
               
                 229 
                 710 
                 2-yl 
                 16 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 230-1~230- 
                 6-Chloropyridazin- 
                 A- 
                 H 
                 represents a 
               
               
                 230 
                 710 
                 3-yl 
                 16 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 231-1~231- 
                 2-Chloro-5-oxazolyl 
                 A- 
                 H 
                 represents a 
               
               
                 231 
                 710 
                   
                 16 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 232-1~232- 
                 6-trifluoromethyl- 
                 A- 
                 H 
                 represents a 
               
               
                 232 
                 710 
                 3-pyridyl 
                 16 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 233-1~233- 
                 3-tetrahydrofuranyl 
                 A- 
                 H 
                 represents a 
               
               
                 233 
                 710 
                   
                 16 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 234-1~234- 
                 6-Chloro-3-pyridyl 
                 A-2 
                 H 
                 represents a 
               
               
                 234 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 235-1~235- 
                 6-Chloro-3-pyridyl 
                 A-3 
                 H 
                 represents a 
               
               
                 235 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 236-1~236- 
                 6-Chloro-3-pyridyl 
                 A-4 
                 H 
                 represents a 
               
               
                 236 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 237-1~237- 
                 6-Chloro-3-pyridyl 
                 A-5 
                 H 
                 represents a 
               
               
                 237 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 238-1~238- 
                 6-Chloro-3-pyridyl 
                 A-6 
                 H 
                 represents a 
               
               
                 238 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 239-1~239- 
                 6-Chloro-3-pyridyl 
                 A-7 
                 H 
                 represents a 
               
               
                 239 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 240-1~240- 
                 6-Chloro-3-pyridyl 
                 A-8 
                 H 
                 represents a 
               
               
                 240 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 241-1~241- 
                 6-Chloro-3-pyridyl 
                 A-9 
                 H 
                 represents a 
               
               
                 241 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 242-1~242- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 242 
                 710 
                   
                 10 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 243-1~243- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 243 
                 710 
                   
                 11 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 244-1~244- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 244 
                 710 
                   
                 12 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 245-1~245- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 245 
                 710 
                   
                 17 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 246-1~246- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 246 
                 710 
                   
                 18 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 247-1~247- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 247 
                 710 
                   
                 19 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 248-1~248- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 248 
                 710 
                   
                 20 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 249-1~249- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 249 
                 710 
                   
                 21 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 250-1~250- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 250 
                 710 
                   
                 22 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 251-1~251- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 251 
                 710 
                   
                 23 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 252-1~252- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 252 
                 710 
                   
                 24 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 253-1~253- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 253 
                 710 
                   
                 25 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 254-1~254- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 254 
                 710 
                   
                 26 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 255-1~255- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 255 
                 710 
                   
                 27 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 256-1~256- 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 represents a 
               
               
                 256 
                 710 
                   
                 28 
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 11 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
               
               
                 Table 
                 257-1~257- 
                 6-Chloro-3-pyridyl 
                 A-29 
                 H 
                 represents a 
               
               
                 257 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 258-1~258- 
                 6-Chloro-3-pyridyl 
                 A-30 
                 H 
                 represents a 
               
               
                 258 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 259-1~259- 
                 6-Chloro-3-pyridyl 
                 A-31 
                 H 
                 represents a 
               
               
                 259 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 260-1~260- 
                 6-Chloro-3-pyridyl 
                 A-32 
                 H 
                 represents a 
               
               
                 260 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 261-1~261- 
                 6-Chloro-3-pyridyl 
                 A-33 
                 H 
                 represents a 
               
               
                 261 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 262-1~262- 
                 6-Chloro-3-pyridyl 
                 A-34 
                 H 
                 represents a 
               
               
                 262 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 263-1~263- 
                 6-Chloro-3-pyridyl 
                 A-35 
                 H 
                 represents a 
               
               
                 263 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 264-1~264- 
                 6-Chloro-3-pyridyl 
                 A-36 
                 H 
                 represents a 
               
               
                 264 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 265-1~265- 
                 6-Chloro-3-pyridyl 
                 A-37 
                 H 
                 represents a 
               
               
                 265 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 266-1~266- 
                 6-Chloro-3-pyridyl 
                 A-38 
                 H 
                 represents a 
               
               
                 266 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 267-1~267- 
                 6-Chloro-3-pyridyl 
                 A-39 
                 H 
                 represents a 
               
               
                 267 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 268-1~268- 
                 6-Chloro-3-pyridyl 
                 A-40 
                 H 
                 represents a 
               
               
                 268 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 269-1~269- 
                 6-Chloro-3-pyridyl 
                 A-2 
                 H 
                 represents a 
               
               
                 269 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 270-1~270- 
                 6-Chloro-3-pyridyl 
                 A-3 
                 H 
                 represents a 
               
               
                 270 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 271-1~271- 
                 6-Chloro-3-pyridyl 
                 A-4 
                 H 
                 represents a 
               
               
                 271 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 272-1~272- 
                 6-Chloro-3-pyridyl 
                 A-5 
                 H 
                 represents a 
               
               
                 272 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 273-1~273- 
                 6-Chloro-3-pyridyl 
                 A-6 
                 H 
                 represents a 
               
               
                 273 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 274-1~274- 
                 6-Chloro-3-pyridyl 
                 A-7 
                 H 
                 represents a 
               
               
                 274 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 275-1~275- 
                 6-Chloro-3-pyridyl 
                 A-8 
                 H 
                 represents a 
               
               
                 275 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 276-1~276- 
                 6-Chloro-3-pyridyl 
                 A-9 
                 H 
                 represents a 
               
               
                 276 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 277-1~277- 
                 6-Chloro-3-pyridyl 
                 A-10 
                 H 
                 represents a 
               
               
                 277 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 278-1~278- 
                 6-Chloro-3-pyridyl 
                 A-11 
                 H 
                 represents a 
               
               
                 278 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 279-1~279- 
                 6-Chloro-3-pyridyl 
                 A-12 
                 H 
                 represents a 
               
               
                 279 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 280-1~280- 
                 6-Chloro-3-pyridyl 
                 A-17 
                 H 
                 represents a 
               
               
                 280 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 281-1~281- 
                 6-Chloro-3-pyridyl 
                 A-18 
                 H 
                 represents a 
               
               
                 281 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 282-1~282- 
                 6-Chloro-3-pyridyl 
                 A-19 
                 H 
                 represents a 
               
               
                 282 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 283-1~283- 
                 6-Chloro-3-pyridyl 
                 A-20 
                 H 
                 represents a 
               
               
                 283 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 284-1~284- 
                 6-Chloro-3-pyridyl 
                 A-21 
                 H 
                 represents a 
               
               
                 284 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 285-1~285- 
                 6-Chloro-3-pyridyl 
                 A-22 
                 H 
                 represents a 
               
               
                 285 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 286-1~286- 
                 6-Chloro-3-pyridyl 
                 A-23 
                 H 
                 represents a 
               
               
                 286 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 287-1~287- 
                 6-Chloro-3-pyridyl 
                 A-24 
                 H 
                 represents a 
               
               
                 287 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 288-1~288- 
                 6-Chloro-3-pyridyl 
                 A-25 
                 H 
                 represents a 
               
               
                 288 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 12 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
               
               
                 Table 
                 289-1~289- 
                 6-Chloro-3-pyridyl 
                 A-26 
                 H 
                 represents a 
               
               
                 289 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 290-1~290- 
                 6-Chloro-3-pyridyl 
                 A-27 
                 H 
                 represents a 
               
               
                 290 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 291-1~291- 
                 6-Chloro-3-pyridyl 
                 A-28 
                 H 
                 represents a 
               
               
                 291 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 292-1~292- 
                 6-Chloro-3-pyridyl 
                 A-29 
                 H 
                 represents a 
               
               
                 292 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 293-1~293- 
                 6-Chloro-3-pyridyl 
                 A-30 
                 H 
                 represents a 
               
               
                 293 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 294-1~294- 
                 6-Chloro-3-pyridyl 
                 A-31 
                 H 
                 represents a 
               
               
                 294 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 295-1~295- 
                 6-Chloro-3-pyridyl 
                 A-32 
                 H 
                 represents a 
               
               
                 295 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 296-1~296- 
                 6-Chloro-3-pyridyl 
                 A-33 
                 H 
                 represents a 
               
               
                 296 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 297-1~297- 
                 6-Chloro-3-pyridyl 
                 A-34 
                 H 
                 represents a 
               
               
                 297 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 298-1~298- 
                 6-Chloro-3-pyridyl 
                 A-35 
                 H 
                 represents a 
               
               
                 298 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 299-1~299- 
                 6-Chloro-3-pyridyl 
                 A-36 
                 H 
                 represents a 
               
               
                 299 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 300-1~300- 
                 6-Chloro-3-pyridyl 
                 A-37 
                 H 
                 represents a 
               
               
                 300 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 301-1~301- 
                 6-Chloro-3-pyridyl 
                 A-38 
                 H 
                 represents a 
               
               
                 301 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 302-1~302- 
                 6-Chloro-3-pyridyl 
                 A-39 
                 H 
                 represents a 
               
               
                 302 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 303-1~303- 
                 6-Chloro-3-pyridyl 
                 A-40 
                 H 
                 represents a 
               
               
                 303 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 304-1~304- 
                 6-Chloro-3-pyridyl 
                 A-2 
                 H 
                 represents a 
               
               
                 304 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 305-1~305- 
                 6-Chloro-3-pyridyl 
                 A-3 
                 H 
                 represents a 
               
               
                 305 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 306-1~306- 
                 6-Chloro-3-pyridyl 
                 A-4 
                 H 
                 represents a 
               
               
                 306 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 307-1~307- 
                 6-Chloro-3-pyridyl 
                 A-5 
                 H 
                 represents a 
               
               
                 307 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 308-1~308- 
                 6-Chloro-3-pyridyl 
                 A-6 
                 H 
                 represents a 
               
               
                 308 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 309-1~309- 
                 6-Chloro-3-pyridyl 
                 A-7 
                 H 
                 represents a 
               
               
                 309 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 310-1~310- 
                 6-Chloro-3-pyridyl 
                 A-8 
                 H 
                 represents a 
               
               
                 310 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 311-1~311- 
                 6-Chloro-3-pyridyl 
                 A-9 
                 H 
                 represents a 
               
               
                 311 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 312-1~312- 
                 6-Chloro-3-pyridyl 
                 A-10 
                 H 
                 represents a 
               
               
                 312 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 313-1~313- 
                 6-Chloro-3-pyridyl 
                 A-11 
                 H 
                 represents a 
               
               
                 313 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 314-1~314- 
                 6-Chloro-3-pyridyl 
                 A-12 
                 H 
                 represents a 
               
               
                 314 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 315-1~315- 
                 6-Chloro-3-pyridyl 
                 A-17 
                 H 
                 represents a 
               
               
                 315 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 316-1~316- 
                 6-Chloro-3-pyridyl 
                 A-18 
                 H 
                 represents a 
               
               
                 316 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 317-1~317- 
                 6-Chloro-3-pyridyl 
                 A-19 
                 H 
                 represents a 
               
               
                 317 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 318-1~318- 
                 6-Chloro-3-pyridyl 
                 A-20 
                 H 
                 represents a 
               
               
                 318 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 319-1~319- 
                 6-Chloro-3-pyridyl 
                 A-21 
                 H 
                 represents a 
               
               
                 319 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 320-1~320- 
                 6-Chloro-3-pyridyl 
                 A-22 
                 H 
                 represents a 
               
               
                 320 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 13 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound No 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
               
               
                 Table 
                 321-1~321- 
                 6-Chloro-3- 
                 A-23 
                 H 
                 represents a 
               
               
                 321 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 322-1~322- 
                 6-Chloro-3- 
                 A-24 
                 H 
                 represents a 
               
               
                 322 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 323-1~323- 
                 6-Chloro-3- 
                 A-25 
                 H 
                 represents a 
               
               
                 323 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 324-1~324- 
                 6-Chloro-3- 
                 A-26 
                 H 
                 represents a 
               
               
                 324 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 325-1~325- 
                 6-Chloro-3- 
                 A-27 
                 H 
                 represents a 
               
               
                 325 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 326-1~326- 
                 6-Chloro-3- 
                 A-28 
                 H 
                 represents a 
               
               
                 326 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 327-1~327- 
                 6-Chloro-3- 
                 A-29 
                 H 
                 represents a 
               
               
                 327 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 328-1~328- 
                 6-Chloro-3- 
                 A-30 
                 H 
                 represents a 
               
               
                 328 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 329-1~329- 
                 6-Chloro-3- 
                 A-31 
                 H 
                 represents a 
               
               
                 329 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 330-1~330- 
                 6-Chloro-3- 
                 A-32 
                 H 
                 represents a 
               
               
                 330 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 331-1~331- 
                 6-Chloro-3- 
                 A-33 
                 H 
                 represents a 
               
               
                 331 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 332-1~332- 
                 6-Chloro-3- 
                 A-34 
                 H 
                 represents a 
               
               
                 332 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 333-1~333- 
                 6-Chloro-3- 
                 A-35 
                 H 
                 represents a 
               
               
                 333 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 334-1~334- 
                 6-Chloro-3- 
                 A-36 
                 H 
                 represents a 
               
               
                 334 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 335-1~335- 
                 6-Chloro-3- 
                 A-37 
                 H 
                 represents a 
               
               
                 335 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 336-1~336- 
                 6-Chloro-3- 
                 A-38 
                 H 
                 represents a 
               
               
                 336 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 337-1~337- 
                 6-Chloro-3- 
                 A-39 
                 H 
                 represents a 
               
               
                 337 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 338-1~338- 
                 6-Chloro-3- 
                 A-40 
                 H 
                 represents a 
               
               
                 338 
                 710 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 339-1~339- 
                 2-Chloro-5- 
                 A-2 
                 H 
                 represents a 
               
               
                 339 
                 710 
                 thiazolyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 340-1~340- 
                 3-Trifluoro- 
                 A-3 
                 H 
                 represents a 
               
               
                 340 
                 710 
                 methylphenyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 341-1~341- 
                 2- 
                 A-4 
                 H 
                 represents a 
               
               
                 341 
                 710 
                 Methylphenyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 342-1~342- 
                 3- 
                 A-5 
                 H 
                 represents a 
               
               
                 342 
                 710 
                 Methylphenyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 343-1~343- 
                 4- 
                 A-6 
                 H 
                 represents a 
               
               
                 343 
                 710 
                 Methylphenyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 344-1~344- 
                 4-Trifluoro- 
                 A-7 
                 H 
                 represents a 
               
               
                 344 
                 710 
                 methylphenyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 345-1~345- 
                 2-Trifluoro- 
                 A-8 
                 H 
                 represents a 
               
               
                 345 
                 710 
                 methylphenyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 346-1~346- 
                 2- 
                 A-9 
                 H 
                 represents a 
               
               
                 346 
                 710 
                 Methoxyphenyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 347-1~347- 
                 3- 
                 A-10 
                 H 
                 represents a 
               
               
                 347 
                 710 
                 Methoxyphenyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 348-1~348- 
                 4-l 
                 A-11 
                 H 
                 represents a 
               
               
                 348 
                 710 
                 Methoxypheny 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 349-1~349- 
                 2-Cyanophenyl 
                 A-12 
                 H 
                 represents a 
               
               
                 349 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 350-1~350- 
                 3-Cyanophenyl 
                 A-17 
                 H 
                 represents a 
               
               
                 350 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 351-1~351- 
                 4-Cyanophenyl 
                 A-18 
                 H 
                 represents a 
               
               
                 351 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 352-1~352- 
                 2-Nitrophenyl 
                 A-19 
                 H 
                 represents a 
               
               
                 352 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 14 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Table 
                 353- 
                 3-Nitrophenyl 
                 A-20 
                 H 
                 represents a 
               
               
                 353 
                 1~353- 
                   
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 354- 
                 4-Nitrophenyl 
                 A-21 
                 H 
                 represents a 
               
               
                 354 
                 1~354- 
                   
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 355- 
                 3-Hydroxy-2- 
                 A-22 
                 H 
                 represents a 
               
               
                 355 
                 1~355- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 356- 
                 4-hydroxy-2- 
                 A-23 
                 H 
                 represents a 
               
               
                 356 
                 1~356- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 357- 
                 5-hydroxy-2- 
                 A-24 
                 H 
                 represents a 
               
               
                 357 
                 1~357- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 358- 
                 6-hydroxy-2- 
                 A-25 
                 H 
                 represents a 
               
               
                 358 
                 1~358- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 359- 
                 2-Hydroxy-3- 
                 A-26 
                 H 
                 represents a 
               
               
                 359 
                 1~359- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 360- 
                 5-Hydroxy-3- 
                 A-27 
                 H 
                 represents a 
               
               
                 360 
                 1~360- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 361- 
                 6-Hydroxy-3- 
                 A-28 
                 H 
                 represents a 
               
               
                 361 
                 1~361- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 362- 
                 4-Hydroxy-3- 
                 A-29 
                 H 
                 represents a 
               
               
                 362 
                 1~362- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 363- 
                 2-Hydroxy-4- 
                 A-30 
                 H 
                 represents a 
               
               
                 363 
                 1~363- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 364- 
                 3-Hydroxy-4- 
                 A-31 
                 H 
                 represents a 
               
               
                 364 
                 1~364- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 365- 
                 3-Chloro-2- 
                 A-32 
                 H 
                 represents a 
               
               
                 365 
                 1~365- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 366- 
                 4-Chloro-2- 
                 A-33 
                 H 
                 represents a 
               
               
                 366 
                 1~366- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 367- 
                 5-Chloro-2- 
                 A-34 
                 H 
                 represents a 
               
               
                 367 
                 1~367- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 368- 
                 6-Chloro-2- 
                 A-35 
                 H 
                 represents a 
               
               
                 368 
                 1~368- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 369- 
                 2-Chloro-3- 
                 A-36 
                 H 
                 represents a 
               
               
                 369 
                 1~369- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 370- 
                 5-Chloro-3- 
                 A-37 
                 H 
                 represents a 
               
               
                 370 
                 1~370- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 371- 
                 6-Chloro-3- 
                 A-38 
                 H 
                 represents a 
               
               
                 371 
                 1~371- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 372- 
                 4-Chloro-3- 
                 A-39 
                 H 
                 represents a 
               
               
                 372 
                 1~372- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 373- 
                 2-Chloro-4- 
                 A-40 
                 H 
                 represents a 
               
               
                 373 
                 1~373- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 374- 
                 3-Chloro-4- 
                 A-2 
                 H 
                 represents a 
               
               
                 374 
                 1~374- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 375- 
                 3-bromo-2- 
                 A-3 
                 H 
                 represents a 
               
               
                 375 
                 1~375- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 376- 
                 4-bromo-2- 
                 A-4 
                 H 
                 represents a 
               
               
                 376 
                 1~376- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 377- 
                 5-bromo-2- 
                 A-5 
                 H 
                 represents a 
               
               
                 377 
                 1~377- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 378- 
                 6-bromo-2- 
                 A-6 
                 H 
                 represents a 
               
               
                 378 
                 1~378- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 379- 
                 2-bromo-3- 
                 A-7 
                 H 
                 represents a 
               
               
                 379 
                 1~379- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 380- 
                 5-bromo-3- 
                 A-8 
                 H 
                 represents a 
               
               
                 380 
                 1~380- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 381- 
                 6-bromo-3- 
                 A-9 
                 H 
                 represents a 
               
               
                 381 
                 1~381- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 382- 
                 4-bromo-3- 
                 A-10 
                 H 
                 represents a 
               
               
                 382 
                 1~382- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 383- 
                 2-bromo-4- 
                 A-11 
                 H 
                 represents a 
               
               
                 383 
                 1~383- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 384- 
                 3-bromo-4- 
                 A-12 
                 H 
                 represents a 
               
               
                 384 
                 1~384- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 15 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Table 
                 385- 
                 3-Fluoro-2- 
                 A-17 
                 H 
                 represents a 
               
               
                 385 
                 1~385- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 386- 
                 4-Fluoro-2- 
                 A-18 
                 H 
                 represents a 
               
               
                 386 
                 1~386- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 387- 
                 5-Fluoro-2- 
                 A-19 
                 H 
                 represents a 
               
               
                 387 
                 1~387- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 388- 
                 6-Fluoro-2- 
                 A-20 
                 H 
                 represents a 
               
               
                 388 
                 1~388- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 389- 
                 2-Fluoro-3- 
                 A-21 
                 H 
                 represents a 
               
               
                 389 
                 1~389- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 390- 
                 5-Fluoro-3- 
                 A-22 
                 H 
                 represents a 
               
               
                 390 
                 1~390- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 391- 
                 6-Fluoro-3- 
                 A-23 
                 H 
                 represents a 
               
               
                 391 
                 1~391- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 392- 
                 4-Fluoro-3- 
                 A-24 
                 H 
                 represents a 
               
               
                 392 
                 1~392- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 393- 
                 2-Fluoro-4- 
                 A-25 
                 H 
                 represents a 
               
               
                 393 
                 1~393- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 394- 
                 3-Fluoro-4- 
                 A-26 
                 H 
                 represents a 
               
               
                 394 
                 1~394- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 395- 
                 6-Fluoro-3- 
                 A-27 
                 H 
                 represents a 
               
               
                 395 
                 1~395- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 396- 
                 3-iodo-2- 
                 A-28 
                 H 
                 represents a 
               
               
                 396 
                 1~396- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 397- 
                 4-iodo-2- 
                 A-29 
                 H 
                 represents a 
               
               
                 397 
                 1~397- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 398- 
                 5-iodo-2- 
                 A-30 
                 H 
                 represents a 
               
               
                 398 
                 1~398- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 399- 
                 6-iodo-2~ 
                 A-31 
                 H 
                 represents a 
               
               
                 399 
                 1~399- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 400- 
                 2-iodo-3- 
                 A-32 
                 H 
                 represents a 
               
               
                 400 
                 1~400- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 401- 
                 5-iodo-3- 
                 A-33 
                 H 
                 represents a 
               
               
                 401 
                 1~401- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 402- 
                 6-iodo-3- 
                 A-34 
                 H 
                 represents a 
               
               
                 402 
                 1~402- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 403- 
                 4-iodo~3- 
                 A-35 
                 H 
                 represents a 
               
               
                 403 
                 1~403- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 404- 
                 2-iodo-4- 
                 A-36 
                 H 
                 represents a 
               
               
                 404 
                 1~404- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 405- 
                 3-iodo-4- 
                 A-37 
                 H 
                 represents a 
               
               
                 405 
                 1~405- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 406- 
                 6-iodo-3- 
                 A-38 
                 H 
                 represents a 
               
               
                 406 
                 1~406- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 407- 
                 6-iodo-3- 
                 A-39 
                 H 
                 represents a 
               
               
                 407 
                 1~407- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 408- 
                 2-tetrahydro- 
                 A-40 
                 H 
                 represents a 
               
               
                 408 
                 1~408- 
                 furanyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 409- 
                 3-tetrahydro- 
                 A-2 
                 H 
                 represents a 
               
               
                 409 
                 1~409- 
                 furanyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 410- 
                 5-Chloro-2- 
                 A-3 
                 H 
                 represents a 
               
               
                 410 
                 1~410- 
                 thiazolyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 411- 
                 6-Fluoro-3- 
                 A-4 
                 H 
                 represents a 
               
               
                 411 
                 1~411- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 412- 
                 6-Bromo-3- 
                 A-5 
                 H 
                 represents a 
               
               
                 412 
                 1~412- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 413- 
                 6-Chloro-5- 
                 A-6 
                 H 
                 represents a 
               
               
                 413 
                 1~413- 
                 Fluoro-3- 
                   
                   
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 414- 
                 3,5-Dimethyl- 
                 A-7 
                 H 
                 represents a 
               
               
                 414 
                 1~414- 
                 phenyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 415- 
                 2,3-Dimethyl- 
                 A-8 
                 H 
                 represents a 
               
               
                 415 
                 1~415- 
                 phenyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 416- 
                 2,4-Dimethyo- 
                 A-9 
                 H 
                 represents a 
               
               
                 416 
                 1~416- 
                 phenyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 16 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Table 
                 417- 
                 Phenyl 
                 A-10 
                 H 
                 represents a 
               
               
                 417 
                 1~417- 
                   
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 418- 
                 cyclopentyl 
                 A-11 
                 H 
                 represents a 
               
               
                 418 
                 1~418- 
                   
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 419- 
                 cyclohexyl 
                 A-12 
                 H 
                 represents a 
               
               
                 419 
                 1~419- 
                   
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 420- 
                 3- 
                 A-17 
                 H 
                 represents a 
               
               
                 420 
                 1~420- 
                 methyl- 
                   
                   
                 combination of 
               
               
                   
                 710 
                 cyclohexyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 421- 
                 cyclobutyl 
                 A-18 
                 H 
                 represents a 
               
               
                 421 
                 1~421- 
                   
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 422- 
                 2-oxetanyl 
                 A-19 
                 H 
                 represents a 
               
               
                 422 
                 1~422- 
                   
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 423- 
                 3-oxetanyl 
                 A-20 
                 H 
                 represents a 
               
               
                 423 
                 1~423- 
                   
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 424- 
                 2-thietanyl 
                 A-21 
                 H 
                 represents a 
               
               
                 424 
                 1~424- 
                   
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 425- 
                 3-thietanyl 
                 A-22 
                 H 
                 represents a 
               
               
                 425 
                 1~425- 
                   
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 426- 
                 2-azetidinyl 
                 A-23 
                 H 
                 represents a 
               
               
                 426 
                 1~426- 
                   
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 427- 
                 3-azetidinyl 
                 A-24 
                 H 
                 represents a 
               
               
                 427 
                 1~427- 
                   
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 428- 
                 6-iodo-3- 
                 A-25 
                 H 
                 represents a 
               
               
                 428 
                 1~428- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 429- 
                 6-iodo- 
                 A-26 
                 H 
                 represents a 
               
               
                 429 
                 1~429- 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 430- 
                 2- 
                 A-27 
                 H 
                 represents a 
               
               
                 430 
                 1~430- 
                 tetrahydro- 
                   
                   
                 combination of 
               
               
                   
                 710 
                 furanyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 431- 
                 2-Chloro-3- 
                 A-28 
                 H 
                 represents a 
               
               
                 431 
                 1~431- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 432- 
                 5-Chloro-3- 
                 A-29 
                 H 
                 represents a 
               
               
                 432 
                 1~432- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 433- 
                 6-Chloro-3- 
                 A-30 
                 H 
                 represents a 
               
               
                 433 
                 1~433- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 434- 
                 4-Chloro-3- 
                 A-31 
                 H 
                 represents a 
               
               
                 434 
                 1~434- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 435- 
                 2-Chloro-4- 
                 A-32 
                 H 
                 represents a 
               
               
                 435 
                 1~435- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 436- 
                 3-Chloro-4- 
                 A-33 
                 H 
                 represents a 
               
               
                 436 
                 1~436- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 437- 
                 3-bromo-2- 
                 A-34 
                 H 
                 represents a 
               
               
                 437 
                 1~437- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 438- 
                 4-bromo-2- 
                 A-35 
                 H 
                 represents a 
               
               
                 438 
                 1~438- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 439- 
                 2-FIuoro-4- 
                 A-36 
                 H 
                 represents a 
               
               
                 439 
                 1~439- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 440- 
                 3-Fluoro-4- 
                 A-37 
                 H 
                 represents a 
               
               
                 440 
                 1~440- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 441- 
                 6-Fluoro-3- 
                 A-38 
                 H 
                 represents a 
               
               
                 441 
                 1~441- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 442- 
                 3-iodo- 
                 A-39 
                 H 
                 represents a 
               
               
                 442 
                 1~442- 
                 2-pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 443- 
                 6-Fluoro-3- 
                 A-40 
                 H 
                 represents a 
               
               
                 443 
                 1~443- 
                 pyridyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 444- 
                 2-Chloro-5- 
                 A-38 
                 H 
                 represents a 
               
               
                 444 
                 1~444- 
                 thiazolyl 
                   
                   
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 17 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Table 
                 445- 
                 6-Chloro-3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 445 
                 1~445- 
                 pyridyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 446- 
                 2-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 446 
                 1~446- 
                 thiazolyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 447- 
                 6-Fluoro-3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 447 
                 1~447- 
                 pyridyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 448- 
                 6-Bromo-3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 448 
                 1~448- 
                 pyridyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 449- 
                 6-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 449 
                 1~449- 
                 fluoro-3- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 450- 
                 2-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 450 
                 1~450- 
                 pyrimidinyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 451- 
                 5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 451 
                 1~451- 
                 Chloropyrazin- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 2-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 452- 
                 6- 
                 A-1 
                 3- 
                 represents a 
               
               
                 452 
                 1~452- 
                 Chloropyridazin- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 453- 
                 2-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 453 
                 1~453- 
                 oxazolyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 454- 
                 6- 
                 A-1 
                 3- 
                 represents a 
               
               
                 454 
                 1~454- 
                 trifluoromethyl- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 455- 
                 3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 455 
                 1~455- 
                 tetrahydrofu- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 ranyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 456- 
                 6-Chloro-3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 456 
                 1~456- 
                 pyridyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 457- 
                 2-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 457 
                 1~457- 
                 thiazolyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 458- 
                 6-Fluoro-3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 458 
                 1~458- 
                 pyridyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 459- 
                 6-Bromo-3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 459 
                 1~459- 
                 pyridyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 460- 
                 6-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 460 
                 1~460- 
                 Fluoro-3- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 461- 
                 2-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 461 
                 1~461- 
                 pyrimidinyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 462- 
                 5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 462 
                 1~462- 
                 Chloropyrazin- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 2-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 463- 
                 6- 
                 A-1 
                 4- 
                 represents a 
               
               
                 463 
                 1~463- 
                 Chloropyridazin- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 464- 
                 2-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 464 
                 1~464- 
                 oxazolyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 465- 
                 6- 
                 A-1 
                 4- 
                 represents a 
               
               
                 465 
                 1~465- 
                 trifluoromethyl- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 466- 
                 3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 466 
                 1~466- 
                 tetrahydrofu- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 ranyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 467- 
                 6-Chloro-3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 467 
                 1~467- 
                 pyridyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 468- 
                 2-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 468 
                 1~468- 
                 thiazolyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 469- 
                 6-Fluoro-3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 469 
                 1~469- 
                 pyridyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 470- 
                 6-Bromo-3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 470 
                 1~470- 
                 pyridyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 471- 
                 6-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 471 
                 1~471- 
                 fluoro-3- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 472- 
                 2-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 472 
                 1~472- 
                 pyrimidinyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 473- 
                 5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 473 
                 1~473- 
                 Chloropyrazin- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 2-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 474- 
                 6- 
                 A-1 
                 5- 
                 represents a 
               
               
                 474 
                 1~474- 
                 Chloropyridazin- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 475- 
                 2-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 475 
                 1~475- 
                 oxazolyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 476- 
                 6- 
                 A-1 
                 5- 
                 represents a 
               
               
                 476 
                 1~476- 
                 trifluoromethyl- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 18 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Table 
                 477- 
                 3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 477 
                 1~477- 
                 tetrahydrofu- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 ranyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 478- 
                 6-Chloro-3- 
                 A-1 
                 6- 
                 represents a 
               
               
                 478 
                 1~478- 
                 pyridyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 479- 
                 2-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 479 
                 1~479- 
                 thiazolyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 480- 
                 6-Fluoro-3- 
                 A-1 
                 6- 
                 represents a 
               
               
                 480 
                 1~480- 
                 pyridyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 481- 
                 6-Bromo-3- 
                 A-1 
                 6- 
                 represents a 
               
               
                 481 
                 1~481- 
                 pyridyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 482- 
                 6-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 482 
                 1~482- 
                 fluoro-3- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 483- 
                 2-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 483 
                 1~483- 
                 pyrimidinyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 484- 
                 5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 484 
                 1~484- 
                 Chloropyrazin- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 2-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 485- 
                 6- 
                 A-1 
                 6- 
                 represents a 
               
               
                 485 
                 1~485- 
                 Chloropyridazin- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 486- 
                 2-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 486 
                 1~486- 
                 oxazolyl 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 487- 
                 6- 
                 A-1 
                 6- 
                 represents a 
               
               
                 487 
                 1~487- 
                 trifluoromethyl- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 488- 
                 3- 
                 A-1 
                 6- 
                 represents a 
               
               
                 488 
                 1~488- 
                 tetrahydrofu- 
                   
                 CH3 
                 combination of 
               
               
                   
                 710 
                 ranyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 489- 
                 6-Chloro-3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 489 
                 1~489- 
                 pyridyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 490- 
                 2-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 490 
                 1~490- 
                 thiazolyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 491- 
                 6-Fluoro-3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 491 
                 1~491- 
                 pyridyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 492- 
                 6-Bromo- 
                 A-1 
                 3- 
                 represents a 
               
               
                 492 
                 1~492- 
                 3-pyridyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 493- 
                 6-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 493 
                 1~493- 
                 Fluoro-3- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 494- 
                 2-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 494 
                 1~494- 
                 pyrimidinyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 495- 
                 5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 495 
                 1~495- 
                 Chloropyrazin- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 2-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 496- 
                 6- 
                 A-1 
                 3- 
                 represents a 
               
               
                 496 
                 1~496- 
                 Chloropyridazin- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 497- 
                 2-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 497 
                 1~497- 
                 oxazolyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 498- 
                 6- 
                 A-1 
                 3- 
                 represents a 
               
               
                 498 
                 1~498- 
                 trifluoromethyl- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 499- 
                 3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 499 
                 1~499- 
                 tetrahydrofu- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 ranyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 500- 
                 6-Chloro-3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 500 
                 1~500- 
                 pyridyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 501- 
                 2-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 501 
                 1~501- 
                 thiazolyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 502- 
                 6-Fluoro-3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 502 
                 1~502- 
                 pyridyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 503- 
                 6-Bromo-3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 503 
                 1~503- 
                 pyridyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 504- 
                 6-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 504 
                 1~504- 
                 fluoro-3- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 505- 
                 2-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 505 
                 1~505- 
                 pyrimidinyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 506- 
                 5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 506 
                 1~506- 
                 Chloropyrazin- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 2-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 507- 
                 6- 
                 A-1 
                 4- 
                 represents a 
               
               
                 507 
                 1~507- 
                 Chloropyridazin- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 508- 
                 2-Chloro-5- 
                 A-1 
                 4- 
                 represents a 
               
               
                 508 
                 1~508- 
                 oxazolyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 19 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Table 
                 509~ 
                 6-tri- 
                 A-1 
                 4- 
                 represents a 
               
               
                 509 
                 1~509- 
                 fluoromethyl- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 510- 
                 3- 
                 A-1 
                 4- 
                 represents a 
               
               
                 510 
                 1~510- 
                 tetrahydro- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 furanyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 511- 
                 6-Chloro-3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 511 
                 1~511- 
                 pyridyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 512- 
                 2-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 512 
                 1~512- 
                 thiazolyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 513- 
                 6-Fluoro-3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 513 
                 1~513- 
                 pyridyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 514- 
                 6-Bromo-3- 
                 A-1 
                 5- 
                 represents a 
               
               
                 514 
                 1~514- 
                 pyridyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 515- 
                 6-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 515 
                 1~515- 
                 fluoro-3- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 516- 
                 2-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 516 
                 1~516- 
                 pyrimidinyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 517- 
                 5-Chloro- 
                 A-1 
                 5- 
                 represents a 
               
               
                 517 
                 1~517- 
                 pyrazin-2-yl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 518- 
                 6-Chloro- 
                 A-1 
                 5- 
                 represents a 
               
               
                 518 
                 1~518- 
                 pyridazin- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 519- 
                 2-Chloro-5- 
                 A-1 
                 5- 
                 represents a 
               
               
                 519 
                 1~519- 
                 oxazolyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 520- 
                 6-tri- 
                 A-1 
                 5- 
                 represents a 
               
               
                 520 
                 1~520- 
                 fluoromethyl- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 521- 
                 3-tetrahydro- 
                 A-1 
                 5- 
                 represents a 
               
               
                 521 
                 1~521- 
                 furanyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 522- 
                 6-Chloro-3- 
                 A-1 
                 6- 
                 represents a 
               
               
                 522 
                 1~522- 
                 pyridyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 523- 
                 2-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 523 
                 1~523- 
                 thiazolyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 524- 
                 6-Fluoro-3- 
                 A-1 
                 6- 
                 represents a 
               
               
                 524 
                 1~524- 
                 pyridyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 525- 
                 6-Bromo-3- 
                 A-1 
                 6- 
                 represents a 
               
               
                 525 
                 1~525- 
                 pyridyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 526- 
                 6-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 526 
                 1~526- 
                 Fluoro-3- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 527- 
                 2-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 527 
                 1~527- 
                 pyrimidinyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 528- 
                 5-Chloro- 
                 A-1 
                 6- 
                 represents a 
               
               
                 528 
                 1~528- 
                 pyrazin-2-yl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 529- 
                 6-Chloro- 
                 A-1 
                 6- 
                 represents a 
               
               
                 529 
                 1~529- 
                 pyridazin- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 3-yl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 530- 
                 2-Chloro-5- 
                 A-1 
                 6- 
                 represents a 
               
               
                 530 
                 1~530- 
                 oxazolyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 531- 
                 6-tri- 
                 A-1 
                 6- 
                 represents a 
               
               
                 531 
                 1~531- 
                 fluoromethyl- 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                 3-pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 532- 
                 3-tetra- 
                 A-1 
                 6- 
                 represents a 
               
               
                 532 
                 1~532- 
                 hydrofuranyl 
                   
                 NO2 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 533- 
                 6-Chloro-3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 533 
                 1~533- 
                 pyridyl 
                   
                 OCH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 534- 
                 2-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 534 
                 1~534- 
                 thiazolyl 
                   
                 OCH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 535- 
                 6-Fluoro-3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 535 
                 1~535- 
                 pyridyl 
                   
                 OCH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 536- 
                 6-Bromo-3- 
                 A-1 
                 3- 
                 represents a 
               
               
                 536 
                 1~536- 
                 pyridyl 
                   
                 OCH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 537- 
                 6-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 537 
                 1~537- 
                 fluoro-3- 
                   
                 OCH3 
                 combination of 
               
               
                   
                 710 
                 pyridyl 
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 538- 
                 2-Chloro-5- 
                 A-1 
                 3- 
                 represents a 
               
               
                 538 
                 1~538- 
                 pyrimidinyl 
                   
                 OCH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 539- 
                 5-Chloro- 
                 A-1 
                 3- 
                 represents a 
               
               
                 539 
                 1~539- 
                 pyrazin-2-yl 
                   
                 OCH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                 Table 
                 540- 
                 6-Chloro- 
                 A-1 
                 3- 
                 represents a 
               
               
                 540 
                 1~540- 
                 pyridazin-3-yl 
                   
                 OCH3 
                 combination of 
               
               
                   
                 710 
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of 
               
               
                   
                   
                   
                   
                   
                 Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 20 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound 
                   
                   
                   
                   
               
               
                   
                 No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Table 
                 541-1~541- 
                 2-Chloro-5-oxazolyl 
                 A-1 
                 3-OCH3 
                 represents a 
               
               
                 541 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 542-1~542- 
                 6-trifluoromethyl- 
                 A-1 
                 3-OCH3 
                 represents a 
               
               
                 542 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 543-1~543- 
                 3-tetrahydrofuranyl 
                 A-1 
                 3-OCH3 
                 represents a 
               
               
                 543 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 544-1~544- 
                 6-Chloro-3-pyridyl 
                 A-1 
                 4-OCH3 
                 represents a 
               
               
                 544 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 545-1~545- 
                 2-Chloro-5-thiazolyl 
                 A-1 
                 4-OCH3 
                 represents a 
               
               
                 545 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 546-1~546- 
                 6-Fluoro-3-pyridyl 
                 A-1 
                 4-OCH3 
                 represents a 
               
               
                 546 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 547-1~547- 
                 6-Bromo-3-pyridyl 
                 A-1 
                 4-OCH3 
                 represents a 
               
               
                 547 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 548-1~548- 
                 6-Chloro-5-Fluoro- 
                 A-1 
                 4-OCH3 
                 represents a 
               
               
                 548 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 549-1~549- 
                 2-Chloro-5-pyrimidinyl 
                 A-1 
                 4-OCH3 
                 represents a 
               
               
                 549 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 550-1~550- 
                 5-Chloropyrazin- 
                 A-1 
                 4-OCH3 
                 represents a 
               
               
                 550 
                 710 
                 2-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 551-1~551- 
                 6-Chloropyridazin- 
                 A-1 
                 4-OCH3 
                 represents a 
               
               
                 551 
                 710 
                 3-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 552-1~552- 
                 2-Chloro-5-oxazolyl 
                 A-1 
                 4-OCH3 
                 represents a 
               
               
                 552 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 553-1~553- 
                 6-trifluoromethyl- 
                 A-1 
                 4-OCH3 
                 represents a 
               
               
                 553 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 554-1~554- 
                 3-tetrahydrofuranyl 
                 A-1 
                 4-OCH3 
                 represents a 
               
               
                 554 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 555-1~555- 
                 6-Chloro-3-pyridyl 
                 A-1 
                 5-OCH3 
                 represents a 
               
               
                 555 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 556-1~556- 
                 2-Chloro-5-thiazolyl 
                 A-1 
                 5-OCH3 
                 represents a 
               
               
                 556 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 557-1~557- 
                 6-Fluoro-3-pyridyl 
                 A-1 
                 5-OCH3 
                 represents a 
               
               
                 557 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 558-1~558- 
                 6-Bromo-3-pyridyl 
                 A-1 
                 5-OCH3 
                 represents a 
               
               
                 558 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 559-1~559- 
                 6-Chloro-5-fluoro- 
                 A-1 
                 5-OCH3 
                 represents a 
               
               
                 559 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 560-1~560- 
                 2-Chloro-5-pyrimidinyl 
                 A-1 
                 5-OCH3 
                 represents a 
               
               
                 560 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 561-1~561- 
                 5-Chloropyrazin- 
                 A-1 
                 5-OCH3 
                 represents a 
               
               
                 561 
                 710 
                 2-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 562-1~562- 
                 6-Chloropyridazin- 
                 A-1 
                 5-OCH3 
                 represents a 
               
               
                 562 
                 710 
                 3-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 563-1~563- 
                 2-Chloro-5-oxazolyl 
                 A-1 
                 5-OCH3 
                 represents a 
               
               
                 563 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 564-1~564- 
                 6-trifluoromethyl- 
                 A-1 
                 5-OCH3 
                 represents a 
               
               
                 564 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 565-1~565- 
                 3-tetrahydrofuranyl 
                 A-1 
                 5-OCH3 
                 represents a 
               
               
                 565 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 566-1~566- 
                 6-Chloro-3-pyridyl 
                 A-1 
                 6-OCH3 
                 represents a 
               
               
                 566 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 567-1~567- 
                 2-Chloro-5-thiazolyl 
                 A-1 
                 6-OCH3 
                 represents a 
               
               
                 567 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 568-1~568- 
                 6-Fluoro-3-pyridyl 
                 A-1 
                 6-OCH3 
                 represents a 
               
               
                 568 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 569-1~569- 
                 6-Bromo-3-pyridyl 
                 A-1 
                 6-OCH3 
                 represents a 
               
               
                 569 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 570-1~570- 
                 6-Chloro-5-Fluoro- 
                 A-1 
                 6-OCH3 
                 represents a 
               
               
                 570 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 571-1~571- 
                 2-Chloro-5-pyrimidinyl 
                 A-1 
                 6-OCH3 
                 represents a 
               
               
                 571 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 572-1~572- 
                 5-Chloropyrazin- 
                 A-1 
                 6-OCH3 
                 represents a 
               
               
                 572 
                 710 
                 2-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 21 
               
             
            
               
                   
               
               
                 Table A 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Compound No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Table 
                 573-1~573- 
                 6-Chloropyridazin- 
                 A-1 
                 6-OCH3 
                 represents a 
               
               
                 573 
                 710 
                 3-yl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 574-1~574- 
                 2-Chloro-5-oxazolyl 
                 A-1 
                 6-OCH3 
                 represents a 
               
               
                 574 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 575-1~575- 
                 6-trifluoromethyl- 
                 A-1 
                 6-OCH3 
                 represents a 
               
               
                 575 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 576-1~576- 
                 3-tetrahydrofuranyl 
                 A-1 
                 6-OCH3 
                 represents a 
               
               
                 576 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 577-1~577- 
                 2,6-dichloro- 
                 A-1 
                 H 
                 represents a 
               
               
                 577 
                 710 
                 3-pyridyl 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 578-1~578- 
                 3-pyridyl 
                 A-1 
                 H 
                 represents a 
               
               
                 578 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 579-1~579- 
                 4-pyridyl 
                 A-1 
                 H 
                 represents a 
               
               
                 579 
                 710 
                   
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                 Table 
                 580-1~580- 
                 6-chloro-3-pyridyl- 
                 A-1 
                 H 
                 represents a 
               
               
                 580 
                 710 
                 N-oxide 
                   
                   
                 combination of 
               
               
                   
                   
                   
                   
                   
                 substituents 
               
               
                   
                   
                   
                   
                   
                 corresponding to 
               
               
                   
                   
                   
                   
                   
                 each row of Table B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE B 
               
               
                   
               
               
                 [Table 22] 
               
               
                 R 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                     R1 
               
               
                   
               
               
                  1 
                   
                 H 
               
               
                  2 
                   
                 CF3 
               
               
                  3 
                   
                 CHF2 
               
               
                  4 
                   
                 CF2Cl 
               
               
                  5 
                   
                 CF2CF3 
               
               
                  6 
                   
                 CH2Cl 
               
               
                  7 
                   
                 CHCl2 
               
               
                  8 
                   
                 CCl3 
               
               
                  9 
                   
                 CHClBr 
               
               
                 10 
                   
                 2,2-difluorocyclopropyl 
               
               
                 11 
                   
                 2,3,3-trifluoroacryl 
               
               
                 12 
                   
                 CH2CHF2 
               
               
                 13 
                   
                 CH2CF3 
               
               
                 14 
                   
                 CH═CH2 
               
               
                 15 
                   
                 CH2C≡CH 
               
               
                 16 
                   
                 CH2CH2≡CH 
               
               
                   
               
               
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                     R2 
               
               
                   
               
               
                 17 
                   
                 CH2CF3 
               
               
                 18 
                   
                 CH(Me)CF3 
               
               
                 19 
                   
                 CH(CF3)2 
               
               
                   
               
               
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                     R3 
               
               
                   
               
               
                 20 
                   
                 CF3 
               
               
                 21 
                   
                 CHF2 
               
               
                 22 
                   
                 CF2Cl 
               
               
                 23 
                   
                 CF2CF3 
               
               
                 24 
                   
                 CH2Cl 
               
               
                 25 
                   
                 CHCl2 
               
               
                 26 
                   
                 CCl3 
               
               
                 27 
                   
                 CHClBr 
               
               
                 28 
                   
                 CHBr2 
               
               
                 29 
                   
                 2,3,3-trifluoroacryl 
               
               
                 30 
                   
                 CH2CHF2 
               
               
                 31 
                   
                 CH2CF3 
               
               
                 32 
                   
                 CH═CH2 
               
               
                 33 
                   
                 CH2C≡CH 
               
               
                 34 
                   
                 CH2CF3 
               
               
                 35 
                   
                 CH2CH2Ph 
               
               
                 36 
                   
                 Me 
               
               
                 37 
                   
                 Et 
               
               
                 38 
                   
                 n-Pr 
               
               
                 39 
                   
                 i-Pr 
               
               
                 40 
                   
                 cyclopropyl 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE B 
               
             
            
               
                   
               
               
                 [Table 23] 
               
               
                 R 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 R4 
                 R5 
               
               
                   
               
               
                 41 
                 H 
                 CF3 
               
               
                 42 
                 Me 
                 CF3 
               
               
                 43 
                 Et 
                 CF3 
               
               
                 44 
                 n-Pr 
                 CF3 
               
               
                 45 
                 i-Pr 
                 CF3 
               
               
                 46 
                 t-Bu 
                 CF3 
               
               
                 47 
                 n-Bu 
                 CF3 
               
               
                 48 
                 n-Pentyl 
                 CF3 
               
               
                 49 
                 n-Hexyl 
                 CF3 
               
               
                 50 
                 cyclopropyl 
                 CF3 
               
               
                 51 
                 cyclobutyl 
                 CF3 
               
               
                 52 
                 cyclopentyl 
                 CF3 
               
               
                 53 
                 cyclohexyl 
                 CF3 
               
               
                 54 
                 CH═CH2 
                 CF3 
               
               
                 55 
                 CH2CH═CH2 
                 CF3 
               
               
                 56 
                 CH2C≡CH 
                 CF3 
               
               
                 57 
                 CH2CH2CΞCH 
                 CF3 
               
               
                 58 
                 CH2CHF2 
                 CF3 
               
               
                 59 
                 CH2CCF3 
                 CF3 
               
               
                 60 
                 CH2CH2Cl 
                 CF3 
               
               
                 61 
                 CH2CHCl2 
                 CF3 
               
               
                 62 
                 2-fluoro-2-chloroethyl 
                 CF3 
               
               
                 63 
                 CH2CCl3 
                 CF3 
               
               
                 64 
                 CH2CN 
                 CF3 
               
               
                 65 
                 CH2CH2CN 
                 CF3 
               
               
                 66 
                 CH2CH(CN)CH2CN 
                 CF3 
               
               
                 67 
                 CH2CH2OH 
                 CF3 
               
               
                 68 
                 CH2CH2CH2OH 
                 CF3 
               
               
                 69 
                 CH2CH(OH)CH2OH 
                 CF3 
               
               
                 70 
                 CH2CH2NO2 
                 CF3 
               
               
                 71 
                 Phenyl 
                 CF3 
               
               
                 72 
                 CH2-Phenyl 
                 CF3 
               
               
                 73 
                 CH(Me)-Phenyl 
                 CF3 
               
               
                 74 
                 C(Me2)-Phenyl 
                 CF3 
               
               
                 75 
                 C(cyclopropyl)-Phenyl 
                 CF3 
               
               
                 76 
                 CH2CH2-Phenyl 
                 CF3 
               
               
                 77 
                 CH2-(2-Methylphenyl) 
                 CF3 
               
               
                 78 
                 CH2-(3-Methylphenyl) 
                 CF3 
               
               
                 79 
                 CH2-(4-Methylphenyl) 
                 CF3 
               
               
                 80 
                 CH2-(2-Methoxylphenyl) 
                 CF3 
               
               
                 81 
                 CH2-(3-Methoxylphenyl) 
                 CF3 
               
               
                 82 
                 CH2-(4-Methoxylphenyl) 
                 CF3 
               
               
                 83 
                 CH2-(2-fluorolphenyl) 
                 CF3 
               
               
                 84 
                 CH2-(3-fluorolphenyl) 
                 CF3 
               
               
                 85 
                 CH2-(4-fluorolphenyl) 
                 CF3 
               
               
                 86 
                 CH2-(2-Chlorophenyl) 
                 CF3 
               
               
                 87 
                 CH2-(3-Chlorophenyl) 
                 CF3 
               
               
                 88 
                 CH2-(4-Chlorophenyl) 
                 CF3 
               
               
                 89 
                 CH2-(2-Bromophenyl) 
                 CF3 
               
               
                 90 
                 CH2-(3-Bromophenyl) 
                 CF3 
               
               
                 91 
                 CH2-(4-Bromophenyl) 
                 CF3 
               
               
                 92 
                 CH2-(2-iodophenyl) 
                 CF3 
               
               
                 93 
                 CH2-(3-iodophenyl) 
                 CF3 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE B 
               
             
            
               
                   
               
               
                 [TABLE 24] 
               
               
                 R 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                   
                 R4 
                 R5 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 94 
                 CH2-(4-iodo- 
                 CF3 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 95 
                 CH2-(1- 
                 CF3 
               
               
                   
                   
                 naphthalenyl) 
                   
               
               
                   
                 96 
                 CH2-(2- 
                 CF3 
               
               
                   
                   
                 naphthalenyl) 
                   
               
               
                   
                 97 
                 naphthalen-1- 
                 CF3 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 98 
                 naphthalen-2- 
                 CF3 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 99 
                 quinolin-2-yl 
                 CF3 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 100 
                 quinolin-7-yl- 
                 CF3 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 101 
                 isoquinolin-7- 
                 CF3 
               
               
                   
                   
                 ylmethyl) 
                   
               
               
                   
                 102 
                 isoquinolin-6- 
                 CF3 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 103 
                 quinolin-6-yl- 
                 CF3 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 104 
                 quinolin-3-yl- 
                 CF3 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 105 
                 isoquinolin-3- 
                 CF3 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 106 
                 isoquinolin-1- 
                 CF3 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 107 
                 isoquinolin-4- 
                 CF3 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 108 
                 quinolin-4-yl- 
                 CF3 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 109 
                 quinolin-5-yl 
                 CF3 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 110 
                 isoquinolin-5- 
                 CF3 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 111 
                 isoquinolin-8- 
                 CF3 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 112 
                 quinolin-8-yl- 
                 CF3 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 113 
                 CH2O-Phenyl 
                 CF3 
               
               
                   
                 114 
                 CH2CH2O-Phenyl 
                 CF3 
               
               
                   
                 115 
                 2-pyridyl 
                 CF3 
               
               
                   
                 116 
                 3-pyridyl 
                 CF3 
               
               
                   
                 117 
                 4-pyridyl 
                 CF3 
               
               
                   
                 118 
                 CH2-(2-pyridyl) 
                 CF3 
               
               
                   
                 119 
                 CH2-(3-pyridyl) 
                 CF3 
               
               
                   
                 120 
                 CH2-(4-Chloro- 
                 CF3 
               
               
                   
                   
                 3-pyridyl) 
                   
               
               
                   
                 121 
                 CH2-(4-pyridyl) 
                 CF3 
               
               
                   
                 122 
                 CH2-(2-thienyl) 
                 CF3 
               
               
                   
                 123 
                 CH2-(3-thienyl) 
                 CF3 
               
               
                   
                 124 
                 CH2-(2-furanyl) 
                 CF3 
               
               
                   
                 125 
                 CH2-(3-furanyl) 
                 CF3 
               
               
                   
                 126 
                 CH2-(2-tetra- 
                 CF3 
               
               
                   
                   
                 hydrofuranyl) 
                   
               
               
                   
                 127 
                 CH2-(3-tetra- 
                 CF3 
               
               
                   
                   
                 hydrofuranyl) 
                   
               
               
                   
                 128 
                 (1H-imidazol- 
                 CF3 
               
               
                   
                   
                 2-yl)methyl 
                   
               
               
                   
                 129 
                 (1H-imidazol- 
                 CF3 
               
               
                   
                   
                 1-yl)methyl 
                   
               
               
                   
                 130 
                 (1H-imidazol- 
                 CF3 
               
               
                   
                   
                 4-yl)methyl 
                   
               
               
                   
                 131 
                 CH2-(2- 
                 CF3 
               
               
                   
                   
                 thiazolyl) 
                   
               
               
                   
                 132 
                 CH2-(3- 
                 CF3 
               
               
                   
                   
                 thiazolyl) 
                   
               
               
                   
                 133 
                 CH2-(2-pyrrol- 
                 CF3 
               
               
                   
                   
                 yl) 
                   
               
               
                   
                 134 
                 CH2-(3-pyrrol- 
                 CF3 
               
               
                   
                   
                 yl) 
                   
               
               
                   
                 135 
                 CH2-(5-methyl- 
                 CF3 
               
               
                   
                   
                 pyrazol-1-yl) 
                   
               
               
                   
                 136 
                 CH2-(1- 
                 CF3 
               
               
                   
                   
                 pyrazolyl) 
                   
               
               
                   
                 137 
                 CH2-(2- 
                 CF3 
               
               
                   
                   
                 pyrazolyl) 
                   
               
               
                   
                 138 
                 CH2-(3- 
                 CF3 
               
               
                   
                   
                 pyrazolyl) 
                   
               
               
                   
                 139 
                 CH2-(4- 
                 CF3 
               
               
                   
                   
                 pyrazolyl) 
                   
               
               
                   
                 140 
                 CH2-(5- 
                 CF3 
               
               
                   
                   
                 pyrazolyl) 
                   
               
               
                   
                 141 
                 CH2-(2-oxazol- 
                 CF3 
               
               
                   
                   
                 yl) 
                   
               
               
                   
                 142 
                 CH2-(3-oxazol- 
                 CF3 
               
               
                   
                   
                 yl) 
                   
               
               
                   
                 143 
                 CH2-(3- 
                 CF3 
               
               
                   
                   
                 isoxazolyl) 
                   
               
               
                   
                 144 
                 CH2-(4- 
                 CF3 
               
               
                   
                   
                 isoxazolyl) 
                   
               
               
                   
                 145 
                 CH2-(5- 
                 CF3 
               
               
                   
                   
                 isoxazolyl) 
                   
               
               
                   
                 146 
                 CH2CH2OCH3 
                 CF3 
               
               
                   
                 147 
                 CH2CH2OCH2CH3 
                 CF3 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE B 
               
             
            
               
                   
               
               
                 [Table 25] 
               
               
                 R 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                   
                 R4 
                 R5 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 148 
                 CH2CH2CH2OCH3 
                 CF3 
               
               
                   
                 149 
                 CH2CH2CH2OCH2CH3 
                 CF3 
               
               
                   
                 150 
                 CH2CH2SCH3 
                 CF3 
               
               
                   
                 151 
                 CH2CH2SCH2CH3 
                 CF3 
               
               
                   
                 152 
                 CH2CH2CH2SCH3 
                 CF3 
               
               
                   
                 153 
                 CH2CH2CH2SCH2CH3 
                 CF3 
               
               
                   
                 154 
                 Me 
                 CHF2 
               
               
                   
                 155 
                 Et 
                 CHF2 
               
               
                   
                 156 
                 n-Pr 
                 CHF2 
               
               
                   
                 157 
                 i-Pr 
                 CHF2 
               
               
                   
                 158 
                 t-Bu 
                 CHF2 
               
               
                   
                 159 
                 n-Bu 
                 CHF2 
               
               
                   
                 160 
                 n-Pentyl 
                 CHF2 
               
               
                   
                 161 
                 n-Hexyl 
                 CHF2 
               
               
                   
                 162 
                 cyclopropyl 
                 CHF2 
               
               
                   
                 163 
                 cyclobutyl 
                 CHF2 
               
               
                   
                 164 
                 cyclopentyl 
                 CHF2 
               
               
                   
                 165 
                 cyclohexyl 
                 CHF2 
               
               
                   
                 166 
                 CH═CH2 
                 CHF2 
               
               
                   
                 167 
                 CH2CH═CH2 
                 CHF2 
               
               
                   
                 168 
                 CH2≡CH 
                 CHF2 
               
               
                   
                 169 
                 CH2CH2C≡CH 
                 CHF2 
               
               
                   
                 170 
                 CH2CHF2 
                 CHF2 
               
               
                   
                 171 
                 CH2CCF3 
                 CHF2 
               
               
                   
                 172 
                 CH2CH2Cl 
                 CHF2 
               
               
                   
                 173 
                 CH2CHCl2 
                 CHF2 
               
               
                   
                 174 
                 2-fluoro-2- 
                 CHF2 
               
               
                   
                   
                 chloroethyl 
                   
               
               
                   
                 175 
                 CH2CCl3 
                 CHF2 
               
               
                   
                 176 
                 CH2CH2CN 
                 CHF2 
               
               
                   
                 177 
                 CH2CH2CH2CN 
                 CHF2 
               
               
                   
                 178 
                 CH2CH(CN)CH2CN 
                 CHF2 
               
               
                   
                 179 
                 CH2CH2OH 
                 CHF2 
               
               
                   
                 180 
                 CH2CH2CH2OH 
                 CHF2 
               
               
                   
                 181 
                 CH2CH(OH)CH2OH 
                 CHF2 
               
               
                   
                 182 
                 CH2CH2NO2 
                 CHF2 
               
               
                   
                 183 
                 Phenyl 
                 CHF2 
               
               
                   
                 184 
                 CH2-Phenyl 
                 CHF2 
               
               
                   
                 185 
                 CH(Me)-Phenyl 
                 CHF2 
               
               
                   
                 186 
                 C(Me2)-Phenyl 
                 CHF2 
               
               
                   
                 187 
                 C(cyclopropyl)- 
                 CHF2 
               
               
                   
                   
                 Phenyl 
                   
               
               
                   
                 188 
                 CH2CH2-Phenyl 
                 CHF2 
               
               
                   
                 189 
                 CH2-(2-Methyl- 
                 CHF2 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 190 
                 CH2-(3-Methyl- 
                 CHF2 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 191 
                 CH2-(4-Methyl- 
                 CHF2 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 192 
                 CH2-(2-Methoxyl- 
                 CHF2 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 193 
                 CH2-(3-Methyl- 
                 CHF2 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 194 
                 CH2-(4-Methyl- 
                 CHF2 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 195 
                 CH2-(2- 
                 CHF2 
               
               
                   
                   
                 fluorolphenyl) 
                   
               
               
                   
                 196 
                 CH2-(3- 
                 CHF2 
               
               
                   
                   
                 fluorolphenyl) 
                   
               
               
                   
                 197 
                 CH2-(4-fluorol- 
                 CHF2 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 198 
                 CH2-(2-Chloro- 
                 CHF2 
               
               
                   
                   
                 phenvl) 
                   
               
               
                   
                 199 
                 CH2-(3-Chloro- 
                 CHF2 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 200 
                 CH2-(4-Chloro- 
                 CHF2 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 201 
                 CH2-(2-Bromo- 
                 CHF2 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE B 
               
             
            
               
                   
               
               
                 [Table 26] 
               
               
                 R 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                   
                 R4 
                 R5 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 202 
                 CH2-(3-Bromo- 
                 CHF2 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 203 
                 CH2-(4-Bromo- 
                 CHF2 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 204 
                 CH2-(2-iodo- 
                 CHF2 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 205 
                 CH2-(3-iodo- 
                 CHF2 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 206 
                 CH2-(4-iodo- 
                 CHF2 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 207 
                 CH2-(1-naph- 
                 CHF2 
               
               
                   
                   
                 thalenyl) 
                   
               
               
                   
                 208 
                 CH2-(2-naph- 
                 CHF2 
               
               
                   
                   
                 thalenyl) 
                   
               
               
                   
                 209 
                 naphthalen-1- 
                 CHF2 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 210 
                 naphthalen-2- 
                 CHF2 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 211 
                 quinolin-2-yl 
                 CHF2 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 212 
                 quinolin-7-yl 
                 CHF2 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 213 
                 isoquinolin-7- 
                 CHF2 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 214 
                 isoquinolin-6- 
                 CHF2 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 215 
                 quinolin-6-yl- 
                 CHF2 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 216 
                 quinolin-3-yl- 
                 CHF2 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 217 
                 isoquinolin-3- 
                 CHF2 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 218 
                 isoquinolin-1- 
                 CHF2 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 219 
                 isoquinolin-4- 
                 CHF2 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 220 
                 quinolin-4-yl- 
                 CHF2 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 221 
                 quinolin-5-yl- 
                 CHF2 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 222 
                 isoquinolin-5- 
                 CHF2 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 223 
                 isoquinolin-8- 
                 CHF2 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 224 
                 quinolin-8-yl- 
                 CHF2 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 225 
                 CH2O-Phenyl 
                 CHF2 
               
               
                   
                 226 
                 CH2CH2O-Phenyl 
                 CHF2 
               
               
                   
                 227 
                 2-pyridyl 
                 CHF2 
               
               
                   
                 228 
                 3-pyridyl 
                 CHF2 
               
               
                   
                 229 
                 4-pyridyl 
                 CHF2 
               
               
                   
                 230 
                 CH2-(2-pyridyl) 
                 CHF2 
               
               
                   
                 231 
                 CH2-(3-pyridyl) 
                 CHF2 
               
               
                   
                 232 
                 CH2-(4-chloro- 
                 CHF2 
               
               
                   
                   
                 3-pyridyl) 
                   
               
               
                   
                 233 
                 CH2-(4-pyridyl) 
                 CHF2 
               
               
                   
                 234 
                 CH2-(2-thienyl) 
                 CHF2 
               
               
                   
                 235 
                 CH2-(3-thienyl) 
                 CHF2 
               
               
                   
                 236 
                 CH2-(2-furanyl) 
                 CHF2 
               
               
                   
                 237 
                 CH2-(3-furanyl) 
                 CHF2 
               
               
                   
                 238 
                 CH2-(2-tetra- 
                 CHF2 
               
               
                   
                   
                 hydrofuranyl) 
                   
               
               
                   
                 239 
                 CH2-(3-tetra- 
                 CHF2 
               
               
                   
                   
                 hydrofuranyl) 
                   
               
               
                   
                 240 
                 (1H-imidazol- 
                 CHF2 
               
               
                   
                   
                 2-yl)methyl 
                   
               
               
                   
                 241 
                 (1H-imidazol- 
                 CHF2 
               
               
                   
                   
                 1-yl)methyl 
                   
               
               
                   
                 242 
                 (1H-imidazol- 
                 CHF2 
               
               
                   
                   
                 4-yl)methyl 
                   
               
               
                   
                 243 
                 CH2-(2- 
                 CHF2 
               
               
                   
                   
                 thiazolyl) 
                   
               
               
                   
                 244 
                 CH2-(3- 
                 CHF2 
               
               
                   
                   
                 thiazolyl) 
                   
               
               
                   
                 245 
                 CH2-(2-pyrrol- 
                 CHF2 
               
               
                   
                   
                 yl) 
                   
               
               
                   
                 246 
                 CH2-(3-pyrrol- 
                 CHF2 
               
               
                   
                   
                 yl) 
                   
               
               
                   
                 247 
                 CH2-(5-methyl- 
                 CHF2 
               
               
                   
                   
                 pyrazol-1-yl) 
                   
               
               
                   
                 248 
                 CH2-(1- 
                 CHF2 
               
               
                   
                   
                 pyrazolyl) 
                   
               
               
                   
                 249 
                 CH2-(2- 
                 CHF2 
               
               
                   
                   
                 pyrazolyl) 
                   
               
               
                   
                 250 
                 CH2-(3- 
                 CHF2 
               
               
                   
                   
                 pyrazolyl) 
                   
               
               
                   
                 251 
                 CH2-(4- 
                 CHF2 
               
               
                   
                   
                 pyrazolyl) 
                   
               
               
                   
                 252 
                 CH2-(5- 
                 CHF2 
               
               
                   
                   
                 pyrazolyl) 
                   
               
               
                   
                 253 
                 CH2-(2-oxazol- 
                 CHF2 
               
               
                   
                   
                 yl) 
                   
               
               
                   
                 254 
                 CH2-(3-oxazol- 
                 CHF2 
               
               
                   
                   
                 yl 
                   
               
               
                   
                 255 
                 CH2-(3- 
                 CHF2 
               
               
                   
                   
                 isoxazolyl) 
                   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE B 
               
             
            
               
                   
               
               
                 [Table 27] 
               
               
                 R 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                   
                 R4 
                 R5 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 256 
                 CH2-(4- 
                 CHF2 
               
               
                   
                   
                 isoxazolyl) 
                   
               
               
                   
                 257 
                 CH2-(5- 
                 CHF2 
               
               
                   
                   
                 isoxazolyl) 
                   
               
               
                   
                 258 
                 CH2CH2OCH3 
                 CHF2 
               
               
                   
                 259 
                 CH2CH2OCH2CH3 
                 CHF2 
               
               
                   
                 260 
                 CH2CH2CH2OCH3 
                 CHF2 
               
               
                   
                 261 
                 CH2CH2CH2OCH2CH3 
                 CHF2 
               
               
                   
                 262 
                 CH2CH2SCH3 
                 CHF2 
               
               
                   
                 263 
                 CH2CH2SCH2CH3 
                 CHF2 
               
               
                   
                 264 
                 CH2CH2CH2SCH3 
                 CHF2 
               
               
                   
                 265 
                 CH2CH2CH2SCH2CH3 
                 CHF2 
               
               
                   
                 266 
                 Me 
                 CF2Cl 
               
               
                   
                 267 
                 Et 
                 CF2Cl 
               
               
                   
                 268 
                 n-Pr 
                 CF2Cl 
               
               
                   
                 269 
                 i-Pr 
                 CF2Cl 
               
               
                   
                 270 
                 t-Bu 
                 CF2Cl 
               
               
                   
                 271 
                 n-Bu 
                 CF2Cl 
               
               
                   
                 272 
                 n-Pentyl 
                 CF2Cl 
               
               
                   
                 273 
                 n-Hexyl 
                 CF2Cl 
               
               
                   
                 274 
                 cyclopropyl 
                 CF2Cl 
               
               
                   
                 275 
                 cyclobutyl 
                 CF2Cl 
               
               
                   
                 276 
                 cyclopentyl 
                 CF2Cl 
               
               
                   
                 277 
                 cyclohexyl 
                 CF2Cl 
               
               
                   
                 278 
                 CH═CH2 
                 CF2Cl 
               
               
                   
                 279 
                 CH2CH═CH2 
                 CF2Cl 
               
               
                   
                 280 
                 CH2C≡CH 
                 CF2Cl 
               
               
                   
                 281 
                 CH2CH2C≡CH 
                 CF2Cl 
               
               
                   
                 282 
                 CH2CHF2 
                 CF2Cl 
               
               
                   
                 283 
                 CH2CCF3 
                 CF2Cl 
               
               
                   
                 284 
                 CH2CH2Cl 
                 CF2Cl 
               
               
                   
                 285 
                 CH2CHCl2 
                 CF2Cl 
               
               
                   
                 286 
                 2-fluoro-2- 
                 CF2Cl 
               
               
                   
                   
                 chloroethyl 
                   
               
               
                   
                 287 
                 CH2CCl3 
                 CF2Cl 
               
               
                   
                 288 
                 CH2CH2CN 
                 CF2Cl 
               
               
                   
                 289 
                 CH2CH2CH2CN 
                 CF2Cl 
               
               
                   
                 290 
                 CH2CH(CN)CH2CN 
                 CF2Cl 
               
               
                   
                 291 
                 CH2CH2OH 
                 CF2Cl 
               
               
                   
                 292 
                 CH2CH2CH2OH 
                 CF2Cl 
               
               
                   
                 293 
                 CH2CH(OH)CH2OH 
                 CF2Cl 
               
               
                   
                 294 
                 CH2CH2NO2 
                 CF2Cl 
               
               
                   
                 295 
                 Phenyl 
                 CF2Cl 
               
               
                   
                 296 
                 CH2-Phenyl 
                 CF2Cl 
               
               
                   
                 297 
                 CH(Me)-Phenyl 
                 CF2Cl 
               
               
                   
                 298 
                 C(Me2)-Phenyl 
                 CF2Cl 
               
               
                   
                 299 
                 C(cyclopropyl)- 
                 CF2Cl 
               
               
                   
                   
                 Phenyl 
                   
               
               
                   
                 300 
                 CH2CH2-Phenyl 
                 CF2Cl 
               
               
                   
                 301 
                 CH2-(2-Methyl- 
                 CF2Cl 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 302 
                 CH2-(3-Methyl- 
                 CF2Cl 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 303 
                 CH2-(4-Methyl- 
                 CF2Cl 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 304 
                 CH2-(2-Methox- 
                 CF2Cl 
               
               
                   
                   
                 ylphenyl) 
                   
               
               
                   
                 305 
                 CH2-(3-Methox- 
                 CF2Cl 
               
               
                   
                   
                 ylphenyl) 
                   
               
               
                   
                 306 
                 CH2-(4-Methox- 
                 CF2Cl 
               
               
                   
                   
                 ylphenyl) 
                   
               
               
                   
                 307 
                 CH2-(2-fluorol- 
                 CF2Cl 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 308 
                 CH2-(3-fluorol- 
                 CF2Cl 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 309 
                 CH2-(4-fluorol- 
                 CF2Cl 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE B 
               
             
            
               
                   
               
               
                 [Table 28] 
               
               
                 R 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                   
                 R4 
                 R5 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 310 
                 CH2-(2-Chloro- 
                 CF2Cl 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 311 
                 CH2-(3-Chloro- 
                 CF2Cl 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 312 
                 CH2-(4-Chloro- 
                 CF2Cl 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 313 
                 CH2-(2-Bromo- 
                 CF2Cl 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 314 
                 CH2-(3-Bromo- 
                 CF2Cl 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 315 
                 CH2-(4-Bromo- 
                 CF2Cl 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 316 
                 CH2-(2-iodo- 
                 CF2Cl 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 317 
                 CH2-(3-iodo- 
                 CF2Cl 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 318 
                 CH2-(4-iodo- 
                 CF2Cl 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 319 
                 CH2-(1-naph- 
                 CF2Cl 
               
               
                   
                   
                 thalenyl) 
                   
               
               
                   
                 320 
                 CH2-(2-naph- 
                 CF2Cl 
               
               
                   
                   
                 thalenyl) 
                   
               
               
                   
                 321 
                 naphthalen-1- 
                 CF2Cl 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 322 
                 naphthalen-2- 
                 CF2Cl 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 323 
                 quinolin-2-yl- 
                 CF2Cl 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 324 
                 quinolin-7-yl- 
                 CF2Cl 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 325 
                 isoquinolin-7- 
                 CF2Cl 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 326 
                 isoquinolin-6- 
                 CF2Cl 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 327 
                 quinolin-6-yl- 
                 CF2Cl 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 328 
                 quinolin-3-yl- 
                 CF2Cl 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 329 
                 isoquinolin-3- 
                 CF2Cl 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 330 
                 isoquinolin-1- 
                 CF2Cl 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 331 
                 isoquinolin-4- 
                 CF2Cl 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 332 
                 quinolin-4-yl- 
                 CF2Cl 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 333 
                 quinolin-5-yl- 
                 CF2Cl 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 334 
                 isoquinolin-5- 
                 CF2Cl 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 335 
                 isoquinolin-8- 
                 CF2Cl 
               
               
                   
                   
                 ylmethyl 
                   
               
               
                   
                 336 
                 quinolin-8-yl- 
                 CF2Cl 
               
               
                   
                   
                 methyl 
                   
               
               
                   
                 337 
                 CH2O-Phenyl 
                 CF2Cl 
               
               
                   
                 338 
                 CH2CH2O-Phenyl 
                 CF2Cl 
               
               
                   
                 339 
                 2-pyridyl 
                 CF2Cl 
               
               
                   
                 340 
                 3-pyridyl 
                 CF2Cl 
               
               
                   
                 341 
                 4-pyridyl 
                 CF2Cl 
               
               
                   
                 342 
                 CH2-(2-pyridyl 
                 CF2Cl 
               
               
                   
                 343 
                 CH2-(3-pyridyl) 
                 CF2Cl 
               
               
                   
                 344 
                 CH2-(4-Chloro- 
                 CF2Cl 
               
               
                   
                   
                 3-pyridyl) 
                   
               
               
                   
                 345 
                 CH2-(4-pyridyl) 
                 CF2Cl 
               
               
                   
                 346 
                 CH2-(2-thienyl) 
                 CF2Cl 
               
               
                   
                 347 
                 CH2-(3-thienyl) 
                 CF2Cl 
               
               
                   
                 348 
                 CH2-(2-furanyl) 
                 CF2Cl 
               
               
                   
                 349 
                 CH2-(3-furanyl) 
                 CF2Cl 
               
               
                   
                 350 
                 CH2-(2-tetra- 
                 CF2Cl 
               
               
                   
                   
                 hydrofuranyl) 
                   
               
               
                   
                 351 
                 CH2-(3-tetra- 
                 CF2Cl 
               
               
                   
                   
                 hydrofuranyl) 
                   
               
               
                   
                 352 
                 (1H-imidazol- 
                 CF2Cl 
               
               
                   
                   
                 2-yl)methyl 
                   
               
               
                   
                 353 
                 (1H-imidazol- 
                 CF2Cl 
               
               
                   
                   
                 1-yl)methyl 
                   
               
               
                   
                 354 
                 (1H-imidazol- 
                 CF2Cl 
               
               
                   
                   
                 4-yl)methyl 
                   
               
               
                   
                 355 
                 CH2-(2- 
                 CF2Cl 
               
               
                   
                   
                 thiazolyl) 
                   
               
               
                   
                 356 
                 CH2-(3- 
                 CF2Cl 
               
               
                   
                   
                 thiazolyl) 
                   
               
               
                   
                 357 
                 CH2-(2-pyrrol- 
                 CF2Cl 
               
               
                   
                   
                 yl) 
                   
               
               
                   
                 358 
                 CH2-(3-pyrrol- 
                 CF2Cl 
               
               
                   
                   
                 yl) 
                   
               
               
                   
                 359 
                 CH2-(1-pyrazol- 
                 CF2Cl 
               
               
                   
                   
                 yl) 
                   
               
               
                   
                 360 
                 CH2-(2-pyrazol- 
                 CF2Cl 
               
               
                   
                   
                 yl) 
                   
               
               
                   
                 361 
                 CH2-(3-pyrazol- 
                 CF2Cl 
               
               
                   
                   
                 yl) 
                   
               
               
                   
                 362 
                 CH2-(4-pyrazol- 
                 CF2Cl 
               
               
                   
                   
                 yl) 
                   
               
               
                   
                 363 
                 CH2-(5-pyrazol- 
                 CF2Cl 
               
               
                   
                   
                 yl) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE B 
               
             
            
               
                   
               
               
                 [Table 29] 
               
               
                 R 
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                   
                 R4 
                 R5 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 364 
                 CH2-(5- 
                 CF2Cl 
               
               
                   
                   
                 pyrazolyl) 
                   
               
               
                   
                 365 
                 CH2-(2- 
                 CF2Cl 
               
               
                   
                   
                 oxazolyl) 
                   
               
               
                   
                 366 
                 CH2-(3- 
                 CF2Cl 
               
               
                   
                   
                 oxazolyl) 
                   
               
               
                   
                 367 
                 CH2-(3- 
                 CF2Cl 
               
               
                   
                   
                 isoxazolyl) 
                   
               
               
                   
                 368 
                 CH2-(4- 
                 CF2Cl 
               
               
                   
                   
                 isoxazolyl) 
                   
               
               
                   
                 369 
                 CH2-(5- 
                 CF2Cl 
               
               
                   
                   
                 isoxazolyl) 
                   
               
               
                   
                 370 
                 CH2CH2OCH3 
                 CF2Cl 
               
               
                   
                 371 
                 CH2CH2OCH2CH3 
                 CF2Cl 
               
               
                   
                 372 
                 CH2CH2CH2OCH3 
                 CF2Cl 
               
               
                   
                 373 
                 CH2CH2CH2OCH2CH3 
                 CF2Cl 
               
               
                   
                 374 
                 CH2CH2SCH3 
                 CF2Cl 
               
               
                   
                 375 
                 CH2CH2SCH2CH3 
                 CF2Cl 
               
               
                   
                 376 
                 CH2CH2CH2SCH3 
                 CF2Cl 
               
               
                   
                 377 
                 CH2CH2CH2SCH2CH3 
                 CF2Cl 
               
               
                   
                 378 
                 Me 
                 CF2CF3 
               
               
                   
                 379 
                 Et 
                 CF2CF3 
               
               
                   
                 380 
                 n-Pr 
                 CF2CF3 
               
               
                   
                 381 
                 i-Pr 
                 CF2CF3 
               
               
                   
                 382 
                 t-Bu 
                 CF2CF3 
               
               
                   
                 383 
                 n-Bu 
                 CF2CF3 
               
               
                   
                 384 
                 n-Pentyl 
                 CF2CF3 
               
               
                   
                 385 
                 n-Hexyl 
                 CF2CF3 
               
               
                   
                 386 
                 cyclopropyl 
                 CF2CF3 
               
               
                   
                 387 
                 cyclobutyl 
                 CF2CF3 
               
               
                   
                 388 
                 cyclopentyl 
                 CF2CF3 
               
               
                   
                 389 
                 cyclohexyl 
                 CF2CF3 
               
               
                   
                 390 
                 CH═CH2 
                 CF2CF3 
               
               
                   
                 391 
                 CH2CH═CH2 
                 CF2CF3 
               
               
                   
                 392 
                 CH2C≡CH 
                 CF2CF3 
               
               
                   
                 393 
                 CH2CH2C≡CH 
                 CF2CF3 
               
               
                   
                 394 
                 CH2CHF2 
                 CF2CF3 
               
               
                   
                 395 
                 CH2CCF3 
                 CF2CF3 
               
               
                   
                 396 
                 CH2CH2Cl 
                 CF2CF3 
               
               
                   
                 397 
                 CH2CHCl2 
                 CF2CF3 
               
               
                   
                 398 
                 2-fluoro-2- 
                 CF2CF3 
               
               
                   
                   
                 chloroethyl 
                   
               
               
                   
                 399 
                 CH2CCl3 
                 CF2CF3 
               
               
                   
                 400 
                 CH2CH2CN 
                 CF2CF3 
               
               
                   
                 401 
                 CH2CH2CH2CN 
                 CF2CF3 
               
               
                   
                 402 
                 CH2CH(CN)CH2CN 
                 CF2CF3 
               
               
                   
                 403 
                 CH2CH2OH 
                 CF2CF3 
               
               
                   
                 404 
                 CH2CH2CH2OH 
                 CF2CF3 
               
               
                   
                 405 
                 CH2CH(OH)CH2OH 
                 CF2CF3 
               
               
                   
                 406 
                 CH2CH2NO2 
                 CF2CF3 
               
               
                   
                 407 
                 Phenyl 
                 CF2CF3 
               
               
                   
                 408 
                 CH2-Phenyl 
                 CF2CF3 
               
               
                   
                 409 
                 CH(Me)-Phenyl 
                 CF2CF3 
               
               
                   
                 410 
                 C(Me2)-Phenyl 
                 CF2CF3 
               
               
                   
                 411 
                 C(cyclopropyl)- 
                 CF2CF3 
               
               
                   
                   
                 Phenyl 
                   
               
               
                   
                 412 
                 CH2CH2-Phenyl 
                 CF2CF3 
               
               
                   
                 413 
                 CH2-(2-Methyl- 
                 CF2CF3 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 414 
                 CH2-(3-Methyl- 
                 CF2CF3 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 415 
                 CH2-(4-Methyl- 
                 CF2CF3 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 416 
                 CH2-(2-Methoxyl- 
                 CF2CF3 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
                 417 
                 CH2-(3-Methoxyl- 
                 CF2CF3 
               
               
                   
                   
                 phenyl) 
                   
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 30 
               
             
            
               
                   
               
               
                 Table B 
               
            
           
           
               
               
            
               
                   
                 R 
               
               
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 R4 
                 R5 
               
               
                   
               
               
                 418 
                 CH2-(4- 
                 CF2CF3 
               
               
                   
                 Methoxylphenyl) 
                   
               
               
                 419 
                 CH2-(2- 
                 CF2CF3 
               
               
                   
                 fluorolphenyl) 
                   
               
               
                 420 
                 CH2-(3- 
                 CF2CF3 
               
               
                   
                 fluorolphenyl) 
                   
               
               
                 421 
                 CH2-(4- 
                 CF2CF3 
               
               
                   
                 fluorolphenyl) 
                   
               
               
                 422 
                 CH2-(2- 
                 CF2CF3 
               
               
                   
                 Chlorophenyl) 
                   
               
               
                 423 
                 CH2-(3- 
                 CF2CF3 
               
               
                   
                 Chlorophenyl) 
                   
               
               
                 424 
                 CH2-(4- 
                 CF2CF3 
               
               
                   
                 Chlorophenyl) 
                   
               
               
                 425 
                 CH2-(2- 
                 CF2CF3 
               
               
                   
                 Bromophenyl) 
                   
               
               
                 426 
                 CH2-(3- 
                 CF2CF3 
               
               
                   
                 Bromophenyl) 
                   
               
               
                 427 
                 CH2-(4- 
                 CF2CF3 
               
               
                   
                 Bromophenyl) 
                   
               
               
                 428 
                 CH2-(2- 
                 CF2CF3 
               
               
                   
                 iodophenyl) 
                   
               
               
                 429 
                 CH2-(3- 
                 CF2CF3 
               
               
                   
                 iodophenyl) 
                   
               
               
                 430 
                 CH2-(4- 
                 CF2CF3 
               
               
                   
                 iodophenyl) 
                   
               
               
                 431 
                 CH2-(1- 
                 CF2CF3 
               
               
                   
                 naphthalenyl) 
                   
               
               
                 432 
                 CH2-(2- 
                 CF2CF3 
               
               
                   
                 naphthalenyl) 
                   
               
               
                 433 
                 naphthalen-1- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 434 
                 naphthalen-2- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 435 
                 quinolin-2- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 436 
                 quinolin-7- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 437 
                 isoquinolin-7- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 438 
                 isoquinolin-6- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 439 
                 quinolin-6- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 440 
                 quinolin-3- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 441 
                 isoquinolin-3- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 442 
                 isoquinolin-1- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 443 
                 isoquinolin-4- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 444 
                 quinolin-4- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 445 
                 quinolin-5- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 446 
                 isoquinolin-5- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 447 
                 isoquinolin-8- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 448 
                 quinolin-8- 
                 CF2CF3 
               
               
                   
                 ylmethyl 
                   
               
               
                 449 
                 CH2O-Phenyl 
                 CF2CF3 
               
               
                 450 
                 CH2CH2O- 
                 CF2CF3 
               
               
                   
                 Phenyl 
                   
               
               
                 451 
                 2-pyridyl 
                 CF2CF3 
               
               
                 452 
                 3-pyridyl 
                 CF2CF3 
               
               
                 453 
                 4-pyridyl 
                 CF2CF3 
               
               
                 454 
                 CH2-(2- 
                 CF2CF3 
               
               
                   
                 pyridyl) 
                   
               
               
                 455 
                 CH2-(3- 
                 CF2CF3 
               
               
                   
                 pyridyl) 
                   
               
               
                 456 
                 CH2-(4-Chloro- 
                 CF2CF3 
               
               
                   
                 3-pyridyl) 
                   
               
               
                 457 
                 CH2-(4- 
                 CF2CF3 
               
               
                   
                 pyridyl) 
                   
               
               
                 458 
                 CH2-(2- 
                 CF2CF3 
               
               
                   
                 thienyl) 
                   
               
               
                 459 
                 CH2-(3- 
                 CF2CF3 
               
               
                   
                 thienyl) 
                   
               
               
                 460 
                 CH2-(2- 
                 CF2CF3 
               
               
                   
                 furanyl) 
                   
               
               
                 461 
                 CH2-(3- 
                 CF2CF3 
               
               
                   
                 furanyl) 
                   
               
               
                 462 
                 CH2-(2-tetra- 
                 CF2CF3 
               
               
                   
                 hydrofuranyl) 
                   
               
               
                 463 
                 CH2-(3-tetra- 
                 CF2CF3 
               
               
                   
                 hydrofuranyl) 
                   
               
               
                 464 
                 (1H-imidazol- 
                 CF2CF3 
               
               
                   
                 2-yl)methyl 
                   
               
               
                 465 
                 (1H-imidazol- 
                 CF2CF3 
               
               
                   
                 1-yImethyl 
                   
               
               
                 466 
                 (1H-imidazol- 
                 CF2CF3 
               
               
                   
                 4-yl)methyl 
                   
               
               
                 467 
                 CH2-(2- 
                 CF2CF3 
               
               
                   
                 thiazolyl) 
                   
               
               
                 468 
                 CH2-(3- 
                 CF2CF3 
               
               
                   
                 thiazolyl) 
                   
               
               
                 469 
                 CH2-(2- 
                 CF2CF3 
               
               
                   
                 pyrrolyl) 
                   
               
               
                 470 
                 CH2-(3- 
                 CF2CF3 
               
               
                   
                 pyrrolyl) 
                   
               
               
                 471 
                 CH2-(5-methyl- 
                 CF2CF3 
               
               
                   
                 pyrazolyl-1-yl) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 31 
               
               
                   
               
               
                 Table B 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                   
                 R 
               
               
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 R4 
                 R5 
               
               
                   
               
               
                 472 
                 CH2-(1-pyrazolyl) 
                 CF2CF3 
               
               
                 473 
                 CH2-(2-pyrazolyl) 
                 CF2CF3 
               
               
                 474 
                 CH2-(3-pyrazolyl) 
                 CF2CF3 
               
               
                 475 
                 CH2-(4-pyrazolyl) 
                 CF2CF3 
               
               
                 476 
                 CH2-(5-pyrazolyl) 
                 CF2CF3 
               
               
                 477 
                 CH2-(2-oxazolyl) 
                 CF2CF3 
               
               
                 478 
                 CH2-(3-oxazolyl) 
                 CF2CF3 
               
               
                 479 
                 CH2-(3-isooxazolyl) 
                 CF2CF3 
               
               
                 480 
                 CH2-(4-isooxazolyl) 
                 CF2CF3 
               
               
                 481 
                 CH2-(5-isooxazolyl) 
                 CF2CF3 
               
               
                 482 
                 CH2CH2OCH3 
                 CF2CF3 
               
               
                 483 
                 CH2CH2OCH2CH3 
                 CF2CF3 
               
               
                 484 
                 CH2CH2CH2OCH3 
                 CF2CF3 
               
               
                 485 
                 CH2CH2CH2OCH2CH3 
                 CF2CF3 
               
               
                 486 
                 CH2CH2SCH3 
                 CF2CF3 
               
               
                 487 
                 CH2CH2SCH2CH3 
                 CF2CF3 
               
               
                 488 
                 CH2CH2CH2SCH3 
                 CF2CF3 
               
               
                 489 
                 CH2CH2CH2SCH2CH3 
                 CF2CF3 
               
               
                 490 
                 Me 
                 CH2CF3 
               
               
                 491 
                 Et 
                 CH2Cl 
               
               
                 492 
                 n-Pr 
                 CHCl2 
               
               
                 493 
                 i-Pr 
                 CCl3 
               
               
                 494 
                 t-Bu 
                 CHClBr 
               
               
                 495 
                 n-Bu 
                 CHBr2 
               
               
                 496 
                 n-Pentyl 
                 CH═CH2 
               
               
                 497 
                 n-Hexyl 
                 CH2CH═CH2 
               
               
                 498 
                 cyclopropyl 
                 CH2C≡CH 
               
               
                   
               
            
           
           
               
               
            
               
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 R6 
                 R7 
               
               
                   
               
               
                 499 
                 H 
                 CF3 
               
               
                 500 
                 Me 
                 CF3 
               
               
                 501 
                 Et 
                 CF3 
               
               
                 502 
                 n-Pr 
                 CF3 
               
               
                 503 
                 i-Pr 
                 CF3 
               
               
                 504 
                 t-Bu 
                 CF3 
               
               
                 505 
                 cyclopropyl 
                 CF3 
               
               
                 506 
                 CH═CH2 
                 CF3 
               
               
                 507 
                 CH2CH═CH2 
                 CF3 
               
               
                 508 
                 CH2C≡CH 
                 CF3 
               
               
                 509 
                 Ph 
                 CF3 
               
               
                 510 
                 CH2Ph 
                 CF3 
               
               
                 511 
                 COMe 
                 CF3 
               
               
                 512 
                 COEt 
                 CF3 
               
               
                 513 
                 CO-n-Pr 
                 CF3 
               
               
                 514 
                 CO-i-Pr 
                 CF3 
               
               
                 515 
                 CO-cyclopropyl 
                 CF3 
               
               
                 516 
                 COCH═CH2 
                 CF3 
               
               
                 517 
                 COCH2CH═CH2 
                 CF3 
               
               
                 518 
                 COCH2C≡CH 
                 CF3 
               
               
                 519 
                 COPh 
                 CF3 
               
               
                 520 
                 CO-(2-pyridyl) 
                 CF3 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 32 
               
             
            
               
                   
               
               
                 Table B 
               
            
           
           
               
               
            
               
                   
                 R 
               
               
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 R6 
                 R7 
               
               
                   
               
               
                 521 
                 CO-(3-pyridyl) 
                 CF3 
               
               
                 522 
                 CO-(4-pyridyl) 
                 CF3 
               
               
                 523 
                 COOMe 
                 CF3 
               
               
                 524 
                 COOEt 
                 CF3 
               
               
                 525 
                 COO-i-Pr 
                 CF3 
               
               
                 526 
                 COO-t-Bu 
                 CF3 
               
               
                 527 
                 COOPh 
                 CF3 
               
               
                 528 
                 SO2Me 
                 CF3 
               
               
                 529 
                 SO2Et 
                 CF3 
               
               
                 530 
                 SO2Ph 
                 CF3 
               
               
                 531 
                 SO2-(4-methylphenyl) 
                 CF3 
               
               
                 532 
                 NHMe 
                 CF3 
               
               
                 533 
                 NHEt 
                 CF3 
               
               
                 534 
                 NH-n-Pr 
                 CF3 
               
               
                 535 
                 NHCH2CH2Cl 
                 CF3 
               
               
                 536 
                 NHCH2Ph 
                 CF3 
               
               
                 537 
                 N(Me)2 
                 CF3 
               
               
                 538 
                 Me 
                 CHF2 
               
               
                 539 
                 Et 
                 CHF2 
               
               
                 540 
                 n-Pr 
                 CHF2 
               
               
                 541 
                 i-Pr 
                 CHF2 
               
               
                 542 
                 t-Bu 
                 CHF2 
               
               
                 543 
                 cyclopropyl 
                 CHF2 
               
               
                 544 
                 CH═CH2 
                 CHF2 
               
               
                 545 
                 CH2CH═CH2 
                 CHF2 
               
               
                 546 
                 CH2C≡CH 
                 CHF2 
               
               
                 547 
                 Ph 
                 CHF2 
               
               
                 548 
                 CH2Ph 
                 CHF2 
               
               
                 549 
                 COMe 
                 CHF2 
               
               
                 550 
                 COEt 
                 CHF2 
               
               
                 551 
                 CO-n-Pr 
                 CHF2 
               
               
                 552 
                 CO-i-Pr 
                 CHF2 
               
               
                 553 
                 CO-cyclopropyl 
                 CHF2 
               
               
                 554 
                 COCH═CH2 
                 CHF2 
               
               
                 555 
                 COCH2CH═CH2 
                 CHF2 
               
               
                 556 
                 COCH2C≡CH 
                 CHF2 
               
               
                 557 
                 COPh 
                 CHF2 
               
               
                 558 
                 CO-(2-pyridyl) 
                 CHF2 
               
               
                 559 
                 CO-(3-pyridyl) 
                 CHF2 
               
               
                 560 
                 CO-(4-pyridyl) 
                 CHF2 
               
               
                 561 
                 COOMe 
                 CHF2 
               
               
                 562 
                 COOEt 
                 CHF2 
               
               
                 563 
                 COO-i-Pr 
                 CHF2 
               
               
                 564 
                 COO-t-Bu 
                 CHF2 
               
               
                 565 
                 COOPh 
                 CHF2 
               
               
                 566 
                 SO2Me 
                 CHF2 
               
               
                 567 
                 SO2Et 
                 CHF2 
               
               
                 568 
                 SO2Ph 
                 CHF2 
               
               
                 569 
                 SO2-(4-methylphenyl) 
                 CHF2 
               
               
                 570 
                 Me 
                 CF2Cl 
               
               
                 571 
                 Et 
                 CF2Cl 
               
               
                 572 
                 n-Pr 
                 CF2Cl 
               
               
                 573 
                 i-Pr 
                 CF2Cl 
               
               
                 574 
                 t-Bu 
                 CF2Cl 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 33 
               
             
            
               
                   
               
               
                 Table B 
               
            
           
           
               
               
            
               
                   
                 R 
               
               
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 R6 
                 R7 
               
               
                   
               
               
                 575 
                 cyclopropyl 
                 CF2Cl 
               
               
                 576 
                 CH═CH2 
                 CF2Cl 
               
               
                 577 
                 CH2CH═CH2 
                 CF2Cl 
               
               
                 578 
                 CH2C≡CH 
                 CF2Cl 
               
               
                 579 
                 Ph 
                 CF2Cl 
               
               
                 580 
                 CH2Ph 
                 CF2Cl 
               
               
                 581 
                 COMe 
                 CF2Cl 
               
               
                 582 
                 COEt 
                 CF2Cl 
               
               
                 583 
                 CO-n-Pr 
                 CF2Cl 
               
               
                 584 
                 CO-i-Pr 
                 CF2Cl 
               
               
                 585 
                 CO-cyclopropyl 
                 CF2Cl 
               
               
                 586 
                 COCH═CH2 
                 CF2Cl 
               
               
                 587 
                 COCH2CH═CH2 
                 CF2Cl 
               
               
                 588 
                 COCH2C≡CH 
                 CF2Cl 
               
               
                 589 
                 COPh 
                 CF2Cl 
               
               
                 590 
                 CO-(2-pyridyl) 
                 CF2Cl 
               
               
                 591 
                 CO-(3-pyridyl) 
                 CF2Cl 
               
               
                 592 
                 CO-(4-pyridyl) 
                 CF2Cl 
               
               
                 593 
                 COOMe 
                 CF2Cl 
               
               
                 594 
                 COOEt 
                 CF2Cl 
               
               
                 595 
                 COO-i-Pr 
                 CF2Cl 
               
               
                 596 
                 COO-t-Bu 
                 CF2Cl 
               
               
                 597 
                 COOPh 
                 CF2Cl 
               
               
                 598 
                 SO2Me 
                 CF2Cl 
               
               
                 599 
                 SO2Et 
                 CF2Cl 
               
               
                 600 
                 SO2Ph 
                 CF2Cl 
               
               
                 601 
                 SO2-(4-methylphenyl) 
                 CF2Cl 
               
               
                 602 
                 Me 
                 CF2CF3 
               
               
                 603 
                 Et 
                 CF2CF3 
               
               
                 604 
                 n-Pr 
                 CF2CF3 
               
               
                 605 
                 i-Pr 
                 CF2CF3 
               
               
                 606 
                 t-Bu 
                 CF2CF3 
               
               
                 607 
                 cyclopropyl 
                 CF2CF3 
               
               
                 608 
                 CH═CH2 
                 CF2CF3 
               
               
                 609 
                 CH2CH═CH2 
                 CF2CF3 
               
               
                 610 
                 CH2C≡CH 
                 CF2CF3 
               
               
                 611 
                 Ph 
                 CF2CF3 
               
               
                 612 
                 CH2Ph 
                 CF2CF3 
               
               
                 613 
                 COMe 
                 CF2CF3 
               
               
                 614 
                 COEt 
                 CF2CF3 
               
               
                 615 
                 CO-n-Pr 
                 CF2CF3 
               
               
                 616 
                 CO-i-Pr 
                 CF2CF3 
               
               
                 617 
                 CO-cyclopropyl 
                 CF2CF3 
               
               
                 618 
                 COCH═CH2 
                 CF2CF3 
               
               
                 619 
                 COCH2CH═CH2 
                 CF2CF3 
               
               
                 620 
                 COCH2C≡CH 
                 CF2CF3 
               
               
                 621 
                 COPh 
                 CF2CF3 
               
               
                 622 
                 CO-(2-pyridyl) 
                 CF2CF3 
               
               
                 623 
                 CO-(3-pyridyl) 
                 CF2CF3 
               
               
                 624 
                 CO-(4-pyridyl) 
                 CF2CF3 
               
               
                 625 
                 COOMe 
                 CF2CF3 
               
               
                 626 
                 COOEt 
                 CF2CF3 
               
               
                 627 
                 COO-i-Pr 
                 CF2CF3 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 34 
               
             
            
               
                   
               
               
                 Table B 
               
            
           
           
               
               
               
            
               
                   
                   
                 R 
               
               
                   
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                   
                 R6 
                 R7 
               
               
                   
                   
               
               
                   
                 628 
                 COO-t-Bu 
                 CF2CF3 
               
               
                   
                 629 
                 COOPh 
                 CF2CF3 
               
               
                   
                 630 
                 SO2Me 
                 CF2CF3 
               
               
                   
                 631 
                 SO2Et 
                 CF2CF3 
               
               
                   
                 632 
                 SO2Ph 
                 CF2CF3 
               
               
                   
                 633 
                 SO2- (4-methylphenyl) 
                 CF2CF3 
               
               
                   
                 634 
                 Me 
                 CH2CF3 
               
               
                   
                 635 
                 Et 
                 CH2Cl 
               
               
                   
                 636 
                 n-Pr 
                 CHCl2 
               
               
                   
                 637 
                 i-Pr 
                 CCl3 
               
               
                   
                 638 
                 t-Bu 
                 CHClBr 
               
               
                   
                 639 
                 cyclopropyl 
                 CHBr2 
               
               
                   
                 640 
                 CH═CH2 
                 CH═CH2 
               
               
                   
                 641 
                 CH2CH═CH2 
                 CH2CH═CH2 
               
               
                   
                 642 
                 CH2C≡CH 
                 CH2C≡CH 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 35 
               
               
                   
               
               
                 Table B 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                   
                 R 
               
               
                   
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                   
                 R1 
               
               
                   
                   
               
               
                   
                 643 
                 C6F5 
               
               
                   
                 644 
                 CH2OCH2C6H5 
               
               
                   
                   
               
               
                   
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                   
                 R2 
               
               
                   
                   
               
               
                   
                 645 
                 CH2C6H5 
               
               
                   
                 646 
                 isopropyl 
               
               
                   
                 647 
                 CH2CH2CH═CH2 
               
               
                   
                   
               
               
                   
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                   
                 R3 
               
               
                   
                   
               
               
                   
                 648 
                 C6F5 
               
               
                   
                 649 
                 CH2OCH2C6H5 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 36 
               
             
            
               
                   
               
               
                 Table B 
               
            
           
           
               
               
               
            
               
                   
                   
                 R 
               
               
                   
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                   
                 R4 
                 R5 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 650 
                 Ethyl 
                 CH2CF3 
               
               
                   
                 651 
                 n-Propyl 
                 CH2CF3 
               
               
                   
                 652 
                 iso-Propyl 
                 CH2CF3 
               
               
                   
                 653 
                 t-Butyl 
                 CH2CF3 
               
               
                   
                 654 
                 n-Butyl 
                 CH2CF3 
               
               
                   
                 655 
                 cyclopropyl 
                 CH2CF3 
               
               
                   
                 656 
                 cyclopentyl 
                 CH2CF3 
               
               
                   
                 657 
                 cyclohexyl 
                 CH2CF3 
               
               
                   
                 658 
                 n-hexa decyl 
                 CF3 
               
               
                   
                 659 
                 n-tridecyl 
                 CF3 
               
               
                   
                 660 
                 CH(CH3)CH2CH3 
                 CF3 
               
               
                   
                 661 
                 CH(CH3)CH2CH2CH3 
                 CF3 
               
               
                   
                 662 
                 CH(CH3)-isopropyl 
                 CF3 
               
               
                   
                 663 
                 1-phenylethyl 
                 CF3 
               
               
                   
                 664 
                 1,2,3,4-tetra- 
                 CF3 
               
               
                   
                   
                 hydronaphthalen-1-yl 
                   
               
               
                   
                 665 
                 1-(naphthalen-1-yl)ethyl 
                 CF3 
               
               
                   
                 666 
                 1-(naphthalen-1-yl)propyl 
                 CF3 
               
               
                   
                 667 
                 1-(furan-2-yl)ethyl 
                 CF3 
               
               
                   
                 668 
                 3.3-dimethylbutan-2-yl 
                 CF3 
               
               
                   
                 669 
                 1-(thiophen-2-yl)ethyl 
                 CF3 
               
               
                   
                 670 
                 CH2CH2F 
                 CF3 
               
               
                   
                 671 
                 n-Octyl 
                 CF3 
               
               
                   
                 672 
                 n-Octyl 
                 CHF2 
               
               
                   
                 673 
                 n-Octyl 
                 CF2Cl 
               
               
                   
                 674 
                 n-Octyl 
                 CF2CF3 
               
               
                   
                 675 
                 n-Octyl 
                 CF2CF3 
               
               
                   
                 676 
                 CH(C6H5)2 
                 CF3 
               
               
                   
                 677 
                 CH(C6H5)2 
                 CHF2 
               
               
                   
                 678 
                 CH(C6H5)2 
                 CF2Cl 
               
               
                   
                 679 
                 CH(C6H5)2 
                 CF2CF3 
               
               
                   
                 680 
                 CH(C6H5)2 
                 CH2CF3 
               
               
                   
                 681 
                 CH(CH2CH3)2 
                 CF3 
               
               
                   
                 682 
                 CH(CH2CH3)2 
                 CHF2 
               
               
                   
                 683 
                 CH(CH2CH3)2 
                 CF2Cl 
               
               
                   
                 684 
                 CH(CH2CH3)2 
                 CF2CF3 
               
               
                   
                 685 
                 CH(CH2CH3)2 
                 CH2CF3 
               
               
                   
                 686 
                 CH(CH2CH2CH3)2 
                 CF3 
               
               
                   
                 687 
                 CH(CH2CH2CH3)2 
                 CHF2 
               
               
                   
                 688 
                 CH(CH2CH2CH3)2 
                 CF2Cl 
               
               
                   
                 689 
                 CH(CH2CH2CH3)2 
                 CF2CF3 
               
               
                   
                 690 
                 CH(CH2CH2CH3)2 
                 CF2CF3 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 37 
               
               
                   
               
               
                 Table B 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                   
                 R 
               
               
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Y1 
                 Y2 
                 Ry 
               
               
                   
               
               
                 691 
                 O 
                 O 
                 Methyl 
               
               
                 692 
                 O 
                 O 
                 Ethyl 
               
               
                 693 
                 O 
                 O 
                 Propyl 
               
               
                 694 
                 O 
                 O 
                 isopropyl 
               
               
                 695 
                 S 
                 O 
                 Methyl 
               
               
                 696 
                 S 
                 O 
                 Ethyl 
               
               
                 697 
                 S 
                 O 
                 Propyl 
               
               
                 698 
                 S 
                 O 
                 isopropyl 
               
               
                 699 
                 S 
                 S 
                 Methyl 
               
               
                 700 
                 S 
                 S 
                 Ethyl 
               
               
                 701 
                 S 
                 S 
                 Propyl 
               
               
                 702 
                 S 
                 S 
                 isopropyl 
               
               
                   
               
            
           
           
               
               
            
               
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 n 
                 Rz 
               
               
                   
               
               
                 703 
                 1 
                 CF3 
               
               
                 704 
                 1 
                 CF2CF3 
               
               
                 705 
                 1 
                 CH2CF3 
               
               
                 706 
                 1 
                 Me 
               
               
                 707 
                 2 
                 CF3 
               
               
                 708 
                 2 
                 CF2CF3 
               
               
                 709 
                 2 
                 CH2CF3 
               
               
                 710 
                 2 
                 Me 
               
               
                   
               
            
           
         
       
     
     Preferred examples of the compound represented by Formula (I) include compounds in the following Tables 38, 39, and 40. 
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 38 
               
               
                   
               
               
                 Com- 
                   
                   
                   
                   
               
               
                 pound 
               
               
                 No 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
               
             
            
               
                 266-2 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 COCF3 
               
               
                   
                   
                 38 
               
               
                 444-2 
                 2-chloro-5-thiazolyl 
                 A- 
                 H 
                 COCF3 
               
               
                   
                   
                 38 
               
               
                 190-2 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 COCF3 
               
               
                   
                   
                 13 
               
               
                 201-2 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 COCF3 
               
               
                   
                   
                 14 
               
               
                 223-2 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 COCF3 
               
               
                   
                   
                 16 
               
               
                 146-2 
                 6-Chloro-3-pyridyl 
                 A-1 
                 3- 
                 COCF3 
               
               
                   
                   
                   
                 OH 
               
               
                 224-2 
                 2-chloro-5-thiazolyl 
                 A- 
                 H 
                 COCF3 
               
               
                   
                   
                 16 
               
               
                 102-2 
                 6-Chloro-3-pyridyl 
                 A-1 
                 3- 
                 COCF3 
               
               
                   
                   
                   
                 CN 
               
               
                 212-2 
                 6-Chloro-3-pyridyl 
                 A- 
                 H 
                 COCF3 
               
               
                   
                   
                 15 
               
               
                 1-20 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 CSCF3 
               
               
                 12-2 
                 2-Chloro-4-pyridyl 
                 A-1 
                 H 
                 COCF3 
               
               
                 213-2 
                 2-chloro-5-thiazolyl 
                 A- 
                 H 
                 COCF3 
               
               
                   
                   
                 15 
               
               
                 1-17 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 COOCH2CF3 
               
               
                 1-18 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 COOCH(Me)CF3 
               
               
                 1-19 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 COOCH(CF3)2 
               
               
                 7-2 
                 5-Chloropyrazin- 
                 A-1 
                 H 
                 COCF3 
               
               
                   
                 2-yl 
               
               
                 1-13 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 COCH2CF3 
               
               
                 168-2 
                 6-Chloro-3-pyridyl 
                 A-1 
                 5- 
                 COCF3 
               
               
                   
                   
                   
                 OH 
               
               
                 1-21 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 CSCHF2 
               
               
                 3-20 
                 6-Fluoro-3-pyridyl 
                 A-1 
                 H 
                 CSCF3 
               
               
                 4-20 
                 6-Bromo-3-pyridyl 
                 A-1 
                 H 
                 CSCF3 
               
               
                 3-3 
                 6-Fluoro-3-pyridyl 
                 A-1 
                 H 
                 COCHF2 
               
               
                 4-3 
                 6-Bromo-3-pyridyl 
                 A-1 
                 H 
                 COCHF2 
               
               
                 5-5 
                 6-Chloro-5-fluoro- 
                 A-1 
                 H 
                 COCF2CF3 
               
               
                   
                 3-pyridyl 
               
               
                 6-5 
                 2-Chloro-5-pyrimidinyl 
                 A-1 
                 H 
                 COCF2CF3 
               
               
                 1-22 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 CSCF2Cl 
               
               
                 1-23 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 CSCF2CF3 
               
               
                 5-20 
                 6-Chloro-5-fluoro- 
                 A-1 
                 H 
                 CSCF3 
               
               
                   
                 3-pyridyl 
               
               
                 5-3 
                 6-Chloro-5-fluoro- 
                 A-1 
                 H 
                 COCHF2 
               
               
                   
                 3-pyridyl 
               
               
                 6-3 
                 2-Chloro-5-pyrimidinyl 
                 A-1 
                 H 
                 COCHF2 
               
               
                 8-2 
                 6-Chloropyridazin- 
                 A-1 
                 H 
                 COCF3 
               
               
                   
                 3-yl 
               
               
                 5-4 
                 6-Chloro-5-fluoro- 
                 A-1 
                 H 
                 COCF2Cl 
               
               
                   
                 3-pyridyl 
               
               
                 4-4 
                 6-Bromo-3-pyridyl 
                 A-1 
                 H 
                 COCF2Cl 
               
               
                 6-4 
                 2-Chloro-5-pyrimidinyl 
                 A-1 
                 H 
                 COCF2Cl 
               
               
                 4-5 
                 6-Bromo-3-pyridyl 
                 A-1 
                 H 
                 COCF2CF3 
               
               
                 2-20 
                 2-chloro-5-thiazolyl 
                 A-1 
                 H 
                 CSCF3 
               
               
                 10-20 
                 6-trifluoromethyl- 
                 A-1 
                 H 
                 CSCF3 
               
               
                   
                 3-pyridyl 
               
               
                 3-4 
                 6-Fluoro-3-pyridyl 
                 A-1 
                 H 
                 COCF2Cl 
               
               
                 3-5 
                 6-Fluoro-3-pyridyl 
                 A-1 
                 H 
                 COCF2CF3 
               
               
                 11-20 
                 3-THF 
                 A-1 
                 H 
                 CSCF3 
               
               
                 1-14 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 COCH═CH2 
               
               
                 1-37 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 CSEt 
               
               
                 1-39 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 CS-i-Pr 
               
               
                 1-40 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 CS-cyclopropyl 
               
               
                 1-15 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 COCH2CΞCH 
               
               
                 1-35 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 CSCH2CH2Ph 
               
               
                 1-501 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOEt)CF3 
               
               
                 1-499 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOH)CF3 
               
               
                 1-510 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOCH2Ph)CF3 
               
               
                 1-511 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOCOMe)CF3 
               
               
                 1-519 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOCOPh)CF3 
               
               
                 1-523 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOCOOMe)CF3 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 39 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
               
               
                 No 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
               
             
            
               
                 1-528 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOSO2Me)CF3 
               
               
                 1-531 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOSO2-(4-Methylphenyl))CF3 
               
               
                 1-507 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOCH2CH═CH2)CF3 
               
               
                 1-516 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOCOCH═CH2)CF3 
               
               
                 1-518 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOCOCH2C≡CH)CF3 
               
               
                 1-527 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOCOOPh)CF3 
               
               
                 1-521 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOCO-3-pyr)CF3 
               
               
                 1-43 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NEt)CF3 
               
               
                 1-536 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOCONHCH2Ph)CF3 
               
               
                 1-42 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NMe)CF3 
               
               
                 1-500 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOMe)CF3 
               
               
                 1-504 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOtBu)CF3 
               
               
                 1-534 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOCONHnPr)CF3 
               
               
                 1-535 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOCONHCH2CH2Cl)CF3 
               
               
                 1-72 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH2Ph)CF3 
               
               
                 1-150 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH2CH2SMe)CF3 
               
               
                 1-67 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH2CH2OH) 
               
               
                 1-515 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOCO-cyclopropyl)CF3 
               
               
                 1-56 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH2CΞCH)CF3 
               
               
                 1-512 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOCOCH2CH3)CF3 
               
               
                 1-514 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NOCOiPr)CF3 
               
               
                 1-50 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N-cyclopropyl)CF3 
               
               
                 1-114 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH2CH2OPh)CF3 
               
               
                 1-44 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N-n-Pr)CF3 
               
               
                 1-118 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH2-(2-pyridyl))CF3 
               
               
                 1-119 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH2-(3-pyridyl))CF3 
               
               
                 1-47 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N-n-Bu)CF3 
               
               
                 1-55 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N—CH2CH═CH2)CF3 
               
               
                 1-122 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH2-(2-thienyl))CF3 
               
               
                 1-45 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N-i-Pr)CF3 
               
               
                 1-124 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH2-(2-furanyl))CF3 
               
               
                 1-126 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH2-(2-tetrahydrofuranyl))CF3 
               
               
                 1-64 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH2CN)CF3 
               
               
                 1-146 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH2CH2OCH3)CF3 
               
               
                 1-52 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N-cyclopentyl)CF3 
               
               
                 1-121 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH2-(4-pyridyl))CF3 
               
               
                 1-53 
                 6~Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N-cyclohexyl)CF3 
               
               
                 1-76 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH2CH2Ph)CF3 
               
               
                 267-2 
                 6-Chloro-3-pyridyl 
                 A-39 
                 H 
                 COCF3 
               
               
                 253-2 
                 6-Chloro-3-pyridyl 
                 A-25 
                 H 
                 COCF3 
               
               
                 251-2 
                 6-Chloro-3-pyridyl 
                 A-23 
                 H 
                 COCF3 
               
               
                 13-2 
                 3-Cyanophenyl 
                 A-1 
                 H 
                 COCF3 
               
               
                 1-1 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 CHO 
               
               
                 1-41 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NH)CF3 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 40 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
               
               
                 No. 
                 Ar 
                 A 
                 Y 
                 R 
               
               
                   
               
             
            
               
                 1-647 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 COOCH2CH2CH═CH2 
               
               
                 1-670 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH2CH2F)CF3 
               
               
                 157-2 
                 6-Chloro-3-pyridyl 
                 A-1 
                 4-OH 
                 COCF3 
               
               
                 1-10 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 CO(2,2-difluonocyclopropyl) 
               
               
                 580-2 
                 6-chloro-3-pyridyl- 
                 A-1 
                 H 
                 COCF3 
               
               
                   
                 N-oxid 
               
               
                 1-671 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N(CH2)7CH3)CF3 
               
               
                 1-658 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N(CH2)15CH3)CF3 
               
               
                 1-659 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N(CH2)11CH3)CF3 
               
               
                 1-660 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH(CH3)CH2CH3)CF3 
               
               
                 1-681 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH(CH2CH3)2)CF3 
               
               
                 1-686 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH(CH2CH2CH3)2)CF3 
               
               
                 1-661 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH(CH3)CH2CH2CH3)CF3 
               
               
                 1-662 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH(iso-propyl)CH3)CF3 
               
               
                 1-663 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N(1-phenylethyl))CF3 
               
               
                 1-664 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N(1,2,3,4-tetrahydronaphthalen-1-yl)CF3 
               
               
                 1-665 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N(1-(naphthalen-1-yl)ethyl))CF3 
               
               
                 1-666 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N(1-(naphthalen-1-yl)propyl))CF3 
               
               
                 1-667 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N(1-(furan-2-yl)ethyl))CF3 
               
               
                 1-676 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═NCH(C6H5)2)CF3 
               
               
                 1-668 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N(3,3-dimethylbutan-2-yl))CF3 
               
               
                 47-2 
                 6-Chloro-3-pyridyl 
                 A-1 
                 6-F 
                 COCF3 
               
               
                 91-2 
                 6-Chloro-3-pyridyl 
                 A-1 
                 6-Cl 
                 COCF3 
               
               
                 478-2 
                 6-Chloro-3-pyridyl 
                 A-1 
                 6-CH3 
                 COCF3 
               
               
                 479-2 
                 2-Chloro-5-thiazolyl 
                 A-1 
                 6-CH3 
                 COCF3 
               
               
                 1-51 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N-cyclobutyl)CF3 
               
               
                 566-2 
                 6-Chloro-3-pyridyl 
                 A-1 
                 6-CH3O 
                 COCF3 
               
               
                 488-2 
                 3- 
                 A-1 
                 6-CH3 
                 COCF3 
               
               
                   
                 tetrahydrofuranyl 
               
               
                 511-2 
                 6-Chloro-3-pyridyl 
                 A-1 
                 5-NO2 
                 COCF3 
               
               
                 1-669 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 C(═N(1-(thiophen- 
               
               
                   
                   
                   
                   
                 2-yl)ethyl))CF3 
               
               
                 179-2 
                 6-Chloro-3-pyridyl 
                 A-1 
                 6-OH 
                 COCF3 (also represents 
               
               
                   
                   
                   
                   
                 a tautomer) 
               
               
                 555-2 
                 6-Chloro-3-pyridyl 
                 A-1 
                 5-OCH3 
                 COCF3 
               
               
                 577-2 
                 2,6-dichrolo-3-pyridyl 
                 A-1 
                 H 
                 COCF3 
               
               
                 544-2 
                 6-Chloro-3-pyridyl 
                 A-1 
                 4-OCH3 
                 COCF3 
               
               
                 168-2 
                 6-Chloro-3-pyridyl 
                 A-1 
                 5-OH 
                 COCF3 
               
               
                 1-644 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 COCH2OCH2C6H5 
               
               
                 578-644 
                 3-pyridyl 
                 A-1 
                 H 
                 COCH2OCH2C6H5 
               
               
                 1-703 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 SOCF3 
               
               
                 1-707 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 SO2CF3 
               
               
                 1-706 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 SOCH3 
               
               
                 1-692 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 P(═O)(OEt)2 
               
               
                 1-700 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 P(═S)(SEt)2 
               
               
                 1-701 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 P(═S)(S-n-propyl)2 
               
               
                 1-702 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 P(═S)(S-isopropyl)2 
               
               
                 1-646 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 COO-iso-Pr 
               
               
                 1-645 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 COOCH2C6H5 
               
               
                 1-643 
                 6-Chloro-3-pyridyl 
                 A-1 
                 H 
                 COC6F5 
               
               
                 2-643 
                 2-Chloro-5-thiazolyl 
                 A-1 
                 H 
                 COC6F5 
               
               
                   
               
            
           
         
       
     
     Examples of particularly preferable compounds include compounds 3-3, 4-3, 5-3, 6-3, 1-20, 1-21, 3-20, 4-20, 1-22, 1-23, 5-20, and 1-45. 
     Examples of insect species against which a pest control agent containing at least one of the compounds of the present invention, which is represented by Formula (I), shows pest control effects are as follows. 
     Examples of agricultural and horticultural pests include lepidopteran pests (for example,  Spodoptera litura , cabbage armyworm,  Mythimna separata , cabbageworm, cabbage moth,  Spodoptera exigua , rice stem borer, grass leaf roller,  Naranga aenescens , tortricid, codling moth, leafminer moth, tussock moth,  Agrotis  spp,  Helicoverpa  spp,  Heliothis  spp and the like), hemipteran pests (for example, aphids (Aphididae, Adelgidae, Phylloxeridae) such as  Myzus persicae, Aphis gossypii, Aphis fabae , corn leaf aphid, pea aphid,  Aulacorthum solani, Aphis craccivora, Macrosiphum euphorbiae, Macrosiphum avenae, Methopolophium dirhodum, Rhopalosiphum padi , greenbug,  Brevicoryne brassicae, Lipaphis erysimi, Aphis spiraecola , Rosy apple aphid, apple blight,  Toxoptera aurantii, Toxoptera citricidus  and the like, leafhoppers such as  Nephotettix cincticeps, Empoasca vitis  and the like, planthoppers such as  Laodelphax striatella, Nilaparvata lugens, Sogatella furcifera  and the like, Pentatomorpha such as  Eysarcoris ventralis, Nezara viridula, Plautia stali, Trigonotylus caelestialium  and the like, whiteflies (Aleyrodidae) such as silverleaf whitefly,  Bemisia tabaci , greenhouse whitefly and the like, scale insects (Diaspididae, Margarodidae, Ortheziidae, Aclerdiae, Dactylopiidae, Kerridae, Pseudococcidae, Coccidae, Eriococcidae, Asterolecaniidae, Beesonidae, Lecanodiaspididae, Cerococcidae and the like) such as  Pseudococcus comstocki, Planococcus citri, Pseudaulacaspis pentagona, Aonidiella aurantii  and the like, coleopteran pests (for example,  Lissorhoptrus oryzophilus, Callosobruchus chinensis, Tenebrio molitor, Diabrotica virgifera virgifera, Diabrotica undecimpunctata howardi, Anomala cuprea, Anomala rufocuprea, Phyllotreta striolata, Aulacophora femoralis, Leptinotarsa decemlineata, Oulema oryzae , Bostrichidae, Cerambycidae and the like), Acarina (for example,  Tetranychus urticae, Tetranychus kanzawai, Panonychus citri  and the like), hymenopteran pests (for example, Tenthredinidae), orthopteran pests (for example, Acridioidea), dipteran pests (for example, housefly and Agromyzidae), thysanopteran pests (for example,  Thrips palmi, Frankliniella occidentalis  and the like), phytoparasitic nematode (for example,  Meloidogyne, Pratylenchus, Aphelenchoides besseyi, Bursaphelenchus xylophilus  and the like), and the like. 
     Examples of animal parasitic pests include Ixodidae (for example,  Amblyomma americanum, Amblyomma maculatum, Boophilus microplus, Dermacentor andersoni, Dermacentor occidentalis, Dermacentor variabilis, Haemaphysalis campanulata, Haemaphysalis flava, Haemaphysalis longicornis, Haemaphysalis megaspinosa  Saito,  Ixodes nipponensis, Ixodes ovatus, Ixodes pacifcus, Ixodes persulcatus, Ixodes ricinus, Ixodes scapularis, Ornithodoros moubata pacifcus  and  Rhipicephalus sanguineus ), Cheyletidae (for example,  Cheyletiella blakei  and  Cheyletiella yasguri ),  Demodex  (for example,  Demodex canis  and  Demodex cati ), Psoroptidae (for example,  Psoroptes communis ), Sarcoptidae (for example, Chorioptes  bovis  and  Otodectes cynotis ), Dermanyssidae (for example,  Ornithonyssus sylviarum ),  Dermanyssus gallinae, Pterolichus  (for example,  Megninia cubitalis  and  Pterolichus obtusus ), Trombiculidae (for example,  Helenicula miyagawai  and  Leptotrombidium akamushi ), Shiphonaptera (for example,  Ctenocephalides felis, Pulex irritans, Xenopsylla cheopis  and  Xenopsylla ), Mallophaga (for example,  Trichodectes canis  and  Menopon gallinae ), Anoplura (for example,  Haematopinus suis, Linognathus setosus, Pediculus humanus humanus, Pediculus humanus, Pthirus pubis  and  Cimex lectularius ),  Musca domestica, Hypoderma bovis, Stomoxys calcitrans , Gasterophilus, Psychodidae (for example,  Phlebotomus ),  Glossina morsitans , Tabanidae,  Aedes  spp. (for example,  Aedes albopictus  and  Aedes aegypti ),  Culex  spp. (for example,  Culex pipiens pallens ), Anophelini, Ceratopogonidae, Simuliidae, Reduviidae,  Monomorium pharaonis , Nematoda (for example,  Strongyloides , Ancylostomatoidea, Strongyloidea (for example,  Haemonchus contortus  and Nippostrongylus  braziliensis ), Trichostrongyloidea, Metastrongyloidea (for example,  Metastrongylus elongatus, Angiostrongylus cantonensis  and  Aelurostrongylus abstrutus ), Oxyuroidea, Haterakoidea (for example,  Ascaridia galli ), Ascaridoidea (for example,  Anisakis simplex, Ascaris suum, Parascaris equorum, Toxocara canis  and  Toxocara cati ), Spiruroidea (for example,  Subuluroidea, Gnathostoma spinigerum, Physaloptea praeputialis, Ascarops strongylina, Draschia megastoma  and  Ascaria hamulosa, Dracunculus medinensis ), Filarioidea (for example,  Dirofilaria immitis , lymphatic filarial,  Onchocerca volvulus  and  Loa loa ), Dioctophymatoidea,  Trichinella  (for example,  Trichuris vulpis  and  Trichinella spiralis )), Trematoda (for example,  Schistosoma japonicum  and  Fasciola hepatica ), Acanthocephala,  Taenia  (for example, Pseudophyllidea (for example,  Spirometra erinaceieuropaei ) and Cyclophyllidea (for example,  Dipylidium caninum )), Protozoa, and the like. 
     Examples of hygiene pests, nuisance pests, stored grain pests, stored product pests and house pests include Culicidae spp. (for example,  Aedes albopictus  and  Culex pipiens pallens ),  Periplaneta  (for example,  Periplaneta fuliginosa, Periplaneta japonica  and  Blattella germanica ), Acaridae (for example, Tyrophagusputrescentiae), Diptera (for example, housefly, Sarcophagaperegrina, Psychodidae,  Drosophila  and Chironomus), Simuliidae, Ceratopogonidae, hymenopteran insects (for example, Formicidae such as  Camponotus japonicus, Solenopsis  spp. and the like and Hymenoptera such as  Vespa mandarinia ), Arthropod of Isopoda (for example,  Porcellio scaber, Ligia exotica  and  Armadillidium vulgare ), hemipteran insescts (for example,  Cimex lectularius ), Arthropod of Myriapoda (for example, centipedes, millipedes and Diplopoda), Arthropod of Araneae (for example,  Heteropoda venatoria ), coleopteran insects (for example,  Anisodactylus signatus ), Arthropod of Collembola (for example,  Onychiurus folsomi ), dermapteran insects (for example,  Labidura riparia ), orthopteran insects (for example, Stenopelmatidae), coleopteran insects (for example,  Callosobruchus chinensis, Sitophilus zeamais, Tenebroides mauritanicus, Tribolium castaneum, Anthrenus museorum, Anobiidae, Scolytidae  spp., Dermestidae and  Chlorophorus diadema inhirsutus  Matsushita), lepidopteran insects (for example, Pyralidae and Tineidae), Hemipeplidae, isopteran insects (for example,  Coptotermes formosanus, Incisitermes minor  (Hagen) and  Odontotermes formosanus ), Thysanura (for example,  Ctenolepisma villosa ) and the like. 
     Among them, preferred examples of insect species to which the pest control agent of the present invention is applied include lepidopteran pests, hemipteran pests, thysanopteran pests, dipteran pests, coleopteran pests, animal parasitic Shiphonaptera or Acari,  Dirofilaria immitis , mosquitoes,  Periplaneta  and isopteran insects (for example, at least one insect species selected from the group consisting of cabbage moth,  Spodoptera litura, Aphis gossypii, Myzus persicae, Laodelphax striatella, Nilaparvata lugens, Sogatella furcifera, Nephotettix cincticeps, Trigonotylus caelestialium, Plautia stali, Frankliniella occidentalis, Oulema oryzae, Lissorhoptrus oryzophilus , housefly,  Haemaphysalis longicornis, Dirofilaria immitis, Culex pipiens pallens, Blattella germanica  and  Coptotermes formosanus ), more preferred examples thereof include hemipteran pests, coleopteran insects and Ixodidae, and particularly preferred examples thereof include planthoppers,  Nephotettix cincticeps  and imidacloprid or fipronil-resistant planthoppers. 
     Accordingly, examples of a pest control agent provided by the present invention include an agricultural and horticultural insecticide, an agent for controlling endoparasites of an animal, an agent for controlling ectoparasites of an animal, an agent for controlling hygiene pests, an agent for controlling nuisance pests, an agent for controlling stored grain and stored product pests, an agent for controlling house pests and the like, but preferred examples thereof include an agricultural and horticultural insecticide, an agent for controlling endoparasites of an animal and an agent for controlling ectoparasites of an animal. 
     The pest control agent of the present invention may be prepared by using a carrier according to the use thereof in addition to the compound represented by Formula (I). 
     When the pest control agent of the present invention is an agricultural pest control agent, the agent is usually mixed with an appropriate solid carrier, liquid carrier, gaseous carrier, surfactant, dispersant and other adjuvants for preparation to be provided in any formulation form of emulsifiable concentrates, liquid formulations, suspensions, wettable powders, flowables, dust, granules, tablets, oils, aerosols, fumigants and the like. 
     Examples of the solid carrier include talc, bentonite, clay, kaolin, diatomaceous earth, vermiculite, white carbon, calcium carbonate and the like. 
     Examples of the liquid carrier include alcohols such as methanol, n-hexanol, ethylene glycol and the like, ketones such as acetone, methyl ethyl ketone, cyclohexane and the like, aliphatic hydrocarbons such as n-hexane, kerosene, lamp oil and the like, aromatic hydrocarbons such as toluene, xylene, methyl naphthalene and the like, ethers such as diethyl ether, dioxane, tetrahydrofuran and the like, esters such as ethyl acetate and the like, nitriles such as acetonitrile, isobutyl nitrile and the like, acid amides such as dimethylformamide, dimethylacetamide and the like, vegetable oils such as soybean oil, cotton seed oil and the like, dimethyl sulfoxide, water and the like. 
     Further, examples of the gaseous carrier include LPG, air, nitrogen, carbonic acid gas, dimethyl ether and the like. 
     As the surfactant or dispersant for emulsification, dispersion, spreading and the like, it is possible to use, for example, alkylsulfate esters, alkyl (aryl) sulfonates, polyoxyalkylene alkyl (aryl) ethers, polyhydric alcohol esters, lignin sulfonates or the like. 
     In addition, as the adjuvant for improving the properties of the preparation, it is possible to use, for example, carboxymethylcellulose, gum arabic, polyethylene glycol, calcium stearate or the like. 
     The aforementioned carriers, surfactants, dispersants and adjuvants may be used either alone or in combination, if necessary. 
     The content of active ingredients in the preparation is not particularly limited, but is usually in the range from 1 to 75% by weight for the emulsifiable concentrate, from 0.3 to 25% by weight for the dust, from 1 to 90% by weight for the wettable powder, and from 0.5 to 10% by weight for the granule. 
     The application thereof may be performed before and after the invasion of pest insects. 
     In particular, it is possible to control pests by applying an effective amount of the compounds represented by Formula (I), a preparation including the same and a mixed formulation of other pest control agents with the same to a subject selected from the group consisting of seeds, roots, tubers, bulbs and rhizomes of plants, germinated plants, seedlings, soil, a nutrient solution in nutrient solution culture and a solid medium in nutrient solution culture and penetrating and migrating the compound, the preparation or the mixed formulation into the plants. 
     When the subject to be applied is seeds, roots, tubers, bulbs or rhizomes of plants, appropriate examples of the application method are not particularly limited, but include a dipping method, a dust coating method, a smearing method, a spraying method, a pelleting method, a coating method and the like as long as the penetration and migration are not disturbed. 
     In the case of seeds, examples of the application method include a dipping method, a dust coating method, a smearing method, a spraying method, a pelleting method, a coating method and a fumigating method. The dipping method is a method in which seeds are dipped in a liquid chemical solution, and the dust coating method is classified into a dry dust coating method in which a granular chemical is adhered onto dry seeds, and a wet dust coating method in which a granular chemical is adhered onto seeds which have been slightly soaked in water. Further, the smearing method is a method in which a suspended chemical is applied on the surface of seeds within a mixer and the spraying method is a method in which a suspended chemical is sprayed onto the surface of seeds. In addition, the pelleting method is a method in which a chemical is mixed with a filler and treated when seeds are pelleted together with the filler to form pellets having certain size and shape, the coating method is a method in which a chemical-containing film is coated onto seeds, and the fumigating method is a method in which seeds are sterilized with a chemical which has been gasified within a hermetically sealed container. 
     When the method is applied to germinated plants and seedlings, these plants may be protected by the treatment of the whole or a part thereof by dipping by applying the method after germination, after budding from soil or before transplantation. 
     Further, when the method is applied to seeds, roots, tubers, bulbs, rhizomes or the like, examples of the method also include a method in which seeds, roots, tubers, bulbs, rhizomes or the like are planted or dipped in the chemical for a time enough to penetrate and migrate the chemical into the plants. In this case, the time and temperature for dipping is appropriately determined by those skilled in the art depending on the subject to be applied, kind and amount of drug and the like. Moreover, time for penetration and migration is not particularly limited, but is, for example, 1 hour or longer. In addition, the temperature for penetration and migration is, for example, from 5° C. to 45° C. 
     Examples of the method for applying the chemical to soil include a method in which granules of the compounds of the present invention, a preparation including the same and a mixed formulation of other pest control agents with the same are applied into soil or on soil. Preferred soil application methods include spraying, stripe application, groove application, and planting hole application. Here, the spraying treatment includes a surface treatment over the entire area to be treated and a subsequent mechanical introduction into soil. 
     In addition, application by drenching of soil with a solution prepared by emulsifying or dissolving the nitrogen-containing heterocyclic derivatives having a 2-imino group of the present invention, a preparation including the same and a mixed formulation of other pest control agents with the same in water is also an advantageous soil application method. 
     When the method is applied to a nutrient solution in nutrient solution culture systems such as solid medium cultivation, such as hydroponic culture, sand culture, NFT (nutrient film technique), rock wool culture and the like for the production of vegetables and flowering plants, it is obvious that the compounds of the present invention, a preparation including the same and a mixed formulation of other pest control agents with the same may be applied directly to artificial culture soil including vermiculite and a solid medium including an artificial mat for growing seedling. 
     Further, in the application process, an effective amount of the compound of Formula (I) or salts thereof is preferably an amount enough for the compound of Formula (1) to be penetrated and migrated into the plant in the subsequent penetration and migration process. 
     The effective amount may be appropriately determined by considering the properties of the compound, the kind and amount of subject to be applied, the length of the subsequent penetration and migration process, the temperature and the like, but for example, in the case of a seed, the compound of Formula (I) or salts thereof is applied in an amount of preferably from 1 g to 10 kg and more preferably from 10 g to 1 kg, per 10 kg of the seed. Further, the amount of the compound of Formula (I) or salts thereof applied to soil is preferably from 0.1 g to 10 kg and more preferably from 1 g to 1 kg, per 10 acres of cultivated land. The amount of the compound of Formula (I) or salts thereof treated to leaves and stems of a plant is preferably from 0.1 g to 10 kg and more preferably from 1 g to 1 kg, per 10 acres of cultivated land. 
     When the pest control agent of the present invention is a control agent for animal parasitic pests, the agent is provided in the form of liquid formulations, emulsifiable concentrates, liquid drops, sprays, foam preparations, tablets, granules, fine subtilaes, dust, capsules, chewable formulations, injections, suppositories, creams, shampoos, rinses, resin agents, fumigants, poison baits and the like, and is particularly preferably provided in the form of liquid formulations and liquid drops. 
     The liquid formulation may also be blended with a typical adjuvant for preparation, such as an emulsifier, a dispersant, a spreading agent, a wetting agent, a suspending agent, a preservative, a propellant and the like, and may also be blended with a typical film former. As the surfactant for emulsification, dispersion, spreading and the like, it is possible to use, for example, soaps, polyoxyalkylene alkyl (aryl) ethers, polyoxyethylene alkyl aryl ethers, polyoxyethylene fatty acid ester, higher alcohols, alkyl aryl sulfonates and the like. Examples of dispersants include casein, gelatin, polysaccharides, lignin derivatives, saccharides, synthetic water soluble polymers and the like. Examples of spreading and wetting agents include glycerin, polyethylene glycol and the like. Examples of suspending agents include casein, gelatin, hydroxypropylcellulose, gum arabic and the like, and examples of stabilizers include phenolic antioxidants (BHT, BHA and the like), amine antioxidants (diphenylamine and the like), organic sulfur antioxidants and the like. Examples of preservatives include methyl p-oxybenzoate, ethyl p-oxybenzoate, propyl p-oxybenzoate, butyl p-oxybenzoate and the like. The aforementioned carriers, surfactants, dispersants and adjuvants may be used either alone or in combination, if necessary. In addition, perfumes, synergists and the like may also be contained. It is appropriate that the content of the active ingredients in the pest control agent of the present invention is usually from 1 to 75% by weight for the liquid formulation. 
     Examples of carriers used for the preparation of creams include non-volatile hydrocarbons (liquid paraffin and the like), lanolin hydrogenated fats and oils, higher fatty acids, fatty acid esters, animal and vegetable oils, silicone oils, water and the like. Further, emulsifiers, humectants, antioxidants, perfumes, borax and ultraviolet absorbers may also be used either alone or in combination, if necessary. Examples of emulsifiers include fatty acid sorbitan, polyoxyethylene alkyl ether, and fatty acid polyoxyethylene and the like. It is appropriate that the content of the active ingredients in the pest control agent of the present invention is usually from 0.5 to 70% by weight for the cream. 
     The capsules, pills or tablets may be used such that the active ingredients in the composition of the present invention are divided into suitable small portions, the small portion is mixed with a diluting solution or a carrier such as starch, lactose, talc, or the like, a disintegrator and/or a binder, such as magnesium stearate is added thereto, and the mixture is tabletted, if necessary. 
     Injections need to be prepared as an aseptic solution. For injections, the solution may contain, for example, a salt or glucose enough to isotonicate the solution with blood. Examples of available carriers for the preparation of injections include esters such as fatty acid derivatives of glyceride, benzyl benzoate, isopropyl myristate and propylene glycol, and the like, and organic solvents such as N-methylpyrrolidone and glycerol formal. It is appropriate that the content of the active ingredients in the pest control agent of the present invention is usually from 0.01 to 10% by weight for the injection. 
     Examples of carriers for the preparation of resin agents include vinyl chloride polymers, polyurethane and the like. Plasticizers such as phthalic acid esters, adipic acid esters, stearic acid and the like may be added to these bases, if necessary. After the active ingredients are kneaded into the base, the kneaded product may be molded by injection molding, extrusion molding, press molding and the like. Further, the molded product may also be properly subjected to processes such as molding, cutting or the like to form an ear tag for animals or insecticidal collar for animals. 
     Examples of carriers for toxic baits include bait substances and attraction substances (farina such as wheat flour, corn flour and the like, starch such as corn starch, potato starch and the like, saccharides such as granulated sugar, malt sugar, honey and the like, food flavors such as glycerin, onion flavor, milk flavor and the like, animal powders such as pupal powder, fish powder and the like, various pheromones and the like). It is appropriate that the content of the active ingredients in the pest control agent of the present invention is usually from 0.0001 to 90% by weight for the toxic bait. 
     It is possible to control pests by administering the pest control agent of the present invention into an applied animal either orally or by injection, or wholly or partly administering the agent into the body surface of the applied animal. In addition, it is also possible to control pests by covering places, in which the invasion, parasitism and movement of pests are expected, with the pest control agent of the present invention. 
     The pest control agent of the present invention may be used as it is, but may be diluted with water, liquid carriers, commercially available shampoos, rinses, baits, breed cage bottoms and the like and applied in some cases. 
     Further, the pest control agent according to the present invention may be mixed with other insecticides, fungicides, miticides, herbicides, plant growth regulators, fertilizers and the like and the mixture may be used. Examples of a chemical that may be mixed and used include those described in The Pesticide Manual (13th edition and published by the British Crop Protection Council) or the SHIBUYA INDEX (15th edition, 2010 and published by SHIBUYA INDEX RESEARCH GROUP). As insecticides, miticides or nematicides, more specific examples thereof include an organic phosphoric ester compound such as acephate, dichlorvos, EPN, fenitrothion, fenamifos, prothiofos, profenofos, pyraclofos, chlorpyrifos-methyl, diazinon, fosthiazate, imicyafos, trichlorfon, tetrachlorvinphos, bromofenofos and cythioate, a carbamate-based compound such as methomyl, thiodicarb, aldicarb, oxamyl, propoxur, carbaryl, fenobucarb, ethiofencarb, fenothiocarb, pirimicarb, carbofuran and benfuracarb, a nereistoxin derivative such as cartap and thiocyclam, an organochlorine compound such as dicofol and tetradifon, a pyrethroid-based compound such as allethrin, d•d-T allethrin, dl•d-T80 allethrin, pyrethrins, phenothrin, flumethrin, cyfluthrin, d•d-T80 prarethrin, phthalthrin, transfluthrin, resmethrin, cyphenothrin, pyrethrum extract, synepirin222, synepirin 500, permethrin, tefluthrin, cypermethrin, deltamethrin, cyhalothrin, fenvalerate, fluvalinate, ethofenprox and silafluofen, a benzoyl urea-based compound such as diflubenzuron, teflubenzuron, flufenoxuron, chlorfluazuron and lufenuron, a juvenile hormone-like compound such as methoprene and a molting hormone-like compound such as chromafenozide. In addition, examples of other compounds include buprofezin, hexythiazox, amitraz, chlordimeform, pyridaben, fenpyroxymate, pyrimidifen, tebufenpyrad, tolfenpyrad, fluacrypyrim, acequinocyl, cyflumetofen, flubendiamide, ethiprole, fipronil, etoxazole, imidacloprid, clothianidin, thiamethoxam, acetamiprid, nitenpyram, thiacloprid, dinotefuran, pymetrozine, bifenazate, spirodiclofen, spiromesifen, flonicamid, chlorfenapyr, pyriproxyfen, indoxacarb, pyridalyl, spinosad, avermectin, milbemycin, cyenopyrafen, spinetoram, pyrifluquinazon, chlorantraniliprole, cyantraniliprole, spirotetramat, lepimectin, metaflumizone, pyrafluprole, pyriprole, hydramethylnon, triazamate, sulfoxaflor, flupyradifurone, flometoquin, pyflubumide, pyrafluprole, ivermectin, selamectin, moxidectin, doramectin, eprinomectin, milbemycin oxime, deet, metoxadiazone, cyromazine, triflumuron, star anise oil, triclabendazole, flubendazole, fenbendazole, antimony sodium gluconate, levamisole hydrochloride, bithionol, dichlorophen, phenothiazine, piperazine-carbon disulfide, piperazine phosphate, piperazine adipate, piperazine citrate, melarsomine dihydrochloride, metyridine, santonin, pyrantel pamoate, pyrantel, praziquantel, febantel, emodepside, emamectin benzoate, cycloxaprid, 1-((6-chloropyridin-3-yl)methyl)-4-oxo-3-phenyl-4H-pyr ido[1,2-a]pyrimidin-1-ium-2-olate, an organic metal-based compound, a dinitro-based compound, an organic sulfur compound, a urea-based compound, a triazine-based compound, and a hydrazine-based compound. 
     The pest control agent of the present invention may be used in admixture or in combination with a microbial pesticide such as a BT agent, an entomopathogenic viral agent and the like. 
     Examples of the fungicide used in admixture or in combination include, for example, a strobilurin-based compound such as azoxystrobin, kresoxym-methyl, trifloxystrobin, metominostrobin, and orysastrobin, an anilinopyrimidine-based compound such as mepanipyrim, pyrimethanil and cyprodinil, an azole-based compound such as triadimefon, bitertanol, triflumizole, etaconazole, metoconazole, propiconazole, penconazole, flusilazole, myclobutanil, cyproconazole, tebuconazole, hexaconazole, prochloraz and simeconazole, a quinoxaline-based compound such as quinomethionate, a dithiocarbamate-based compound such as maneb, zineb, mancozeb, polycarbamate and propineb, a phenyl carbamate-based compound such as diethofencarb, an organochlorine compound such as chlorothalonil and quintozene, a benzimidazole-based compound such as benomyl, thiophanate-methyl and carbendazole, a phenyl amide-based compound such as metalaxyl, oxadixyl, ofurase, benalaxyl, furalaxyl and cyprofuram, a sulfenic acid-based compound such as dichlofluanid, a copper-based compound such as copper (II) hydroxide and copper oxyquinoline (oxine-copper), an isoxazole-based compound such as hydroxyisoxazole, an organic phosphorus-based compound such as fosetyl-aluminium and tolclofos-methyl, an N-halogenothioalkyl-based compound such as captan, captafol and folpet, a dicarboximide-based compound such as procymidone, iprodione and vinchlozolin, a carboxanilide-based compound such as flutolanil, mepronil, furamepyr, thifluzamide, boscalid, and penthiopyrad, a morpholine-based compound such as fenpropimorph and dimethomorph, an organic tin-based compound such as fentin hydroxide and fentin acetate, a cyanopyrrole-based compound such as fludioxonil and fenpiclonil, and other examples include tricyclazole, pyroquilon, carpropamid, diclocymet, fenoxanil, fthalide, fluazinam, cymoxanil, triforine, pyrifenox, fenarimol, fenpropidin, pencycuron, ferimzone, cyazofamid, iprovalicarb, benthiavalicarb-isopropyl, iminoctadin-albesilate, cyflufenamid, kasugamycin, validamycin, streptomycin, oxolinic-acid, tebufloquin, probenazole, tiadinil, and isotianil. 
     Examples of the herbicide used in admixture or in combination include lipid synthesis inhibitors, acetolactic acid synthesis inhibitors, photosynthesis inhibitors, protoporphyrinogen IX oxidation inhibitors, bleaching herbicides, amino acid synthesis inhibitors, dihydropteroate synthase inhibitors, cell division inhibitors, very long chain fatty acid synthesis inhibitors, cellulose biosynthesis inhibitors, uncouplers, auxin-like herbicides, auxin transport inhibitors and the like. Specific examples include alloxydim, alloxydim-sodium, butroxydim, clethodim, clodinafop, clodinafop-propargyl, cycloxydim, cyhalofop, cyhalofop-butyl, diclofop, diclofop-methyl, fenoxaprop, fenoxaprop-ethyl, fenoxaprop-P, fenoxaprop-P-ethyl, fluazifop, fluazifop-butyl, fluazifop-P, fluazifop-P-butyl, haloxyfop, haloxyfop-methyl, haloxyfop-P, haloxyfop-P-methyl ester, metamifop, pinoxaden, profoxydim, propaquizafop, quizalofop, quizalofop-ethyl, quizalofop-tefuryl, quizalofop-P, quizalofop-P-ethyl, quizalofop-P-tefuryl, sethoxydim, tepraloxydim, tralkoxydim, benfuresate, butylate, cycloate, dalapon, dimepiperate, ethyl dipropylthiocarbamate (EPTC), esprocarb, ethofumesate, flupropanate, molinate, orbencarb, pebulate, prosulfocarb, trichloroacetic acid (TCA), thiobencarb, tiocarbazil, triallate, vernolate, sulfonylureas (amidosulfuron, azimsulfuron, bensulfuron, bensulfuron-methyl, chlorimuron, chlorimuron-ethyl, chlorsulfuron, cinosulfuron, cyclosulfamuron, ethametsulfuron, ethametsulfuron-methyl, ethoxysulfuron, flazasulfuron, flucetosulfuron, flupyrsulfuron, flupyrsulfuron-methyl-sodium, foramsulfuron, halosulfuron, halosulfuron-methyl, imazosulfuron, iodosulfuron, iodosulfuron-methylsodium, mesosulfuron, metazosulfuron, metsulfuron, metsulfuron-methyl, nicosulfuron, orthosulfamuron, oxasulfuron, primisulfuron, primisulfuron-methyl, propyrisulfuron, prosulfuron, pyrazosulfuron, pyrazosulfuron-ethyl, rimsulfuron, sulfometuron, sulfometuron-methyl, sulfosulfuron, thifensulfuron, thifensulfuron-methyl, triasulfuron, tribenuron, tribenuron-methyl, trifloxysulfuron, triflusulfuron, triflusulfuron-methyl, tritosulfuron), imazamethabenz, imazamethabenz-methyl, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, triazolopyrimidine herbicides (chloransulam, cloransulam-methyl, diclosulam, flumetsulam, florasulam, metosulam, penoxsulam), pyrimisulfan, pyroxsulam, bispyribac, bispyribac-sodium, pyribenzoxim, pyriftalid, pyriminobac, pyriminobac-methyl, pyrithiobac, pyrithiobac-sodium, flucarbazone, flucarbazone-sodium, propoxycarbazone, propoxycarbazone-sodium, thiencarbazone, thiencarbazone-methyl, triazine herbicides (chlorotriazines, triazinones, triazindiones, methylthiotriazines and pyridazinones, such as ametryn, atrazine, chloridazone, cyanazine, desmetryn, dimethametryn, hexazinone, metribuzin, prometon, prometryn, propazin, simazin, simetryn, terbumeton, terbuthylazin, terbutryn and trietazin), aryl ureas (for example, chlorobromuron, chlorotoluron, chloroxuron, dimefuron, diuron, fluometuron, isoproturon, isouron, linuron, metamitron, methabenzthiazuron, metobenzuron, metoxuron, monolinuron, neburon, siduron, tebuthiuron and thiadiazuron), phenyl carbamates (for example, desmedipham, karbutilate, phenmedipham and phenmedipham-ethyl), nitrile herbicides (for example, bromofenoxim, bromoxynil or its salt or ester, and ioxynil or its salt or ester), uracils (for example, bromacil, lenacil and terbacil), bentazon, bentazon-sodium, pyridate, pyridafol, pentanochlor, propanil, photosynthesis inhibitors (for example, diquat, diquat-dibromide, paraquat, paraquat dichloride, paraquat-dimethylsulfate, acifluorfen, acifluorfen-sodium, azafenidin, bencarbazone, benzfendizone, bifenox, butafenacil, carfentrazone, carfentrazone-ethyl, chlomethoxyfen, cinidon-ethyl, fluazolate, flufenpyr, flufenpyr-ethyl, flumiclorac, flumiclorac-pentyl, flumioxazin, fluoroglycofen, fluoroglycofen-ethyl, fluthiacet, fluthiacet-methyl, fomesafen, halosafen, lactofen, oxadiargyl, oxadiazon, oxyfluorfen, pentoxazone, profluazol, pyraclonil, pyraflufen, pyraflufen-ethyl, saflufenacil, sulfentrazone, thidiazimin, beflubutamid, diflufenican, fluridone, flurochloridone, flurtamone, norflurazon, picolinafen, aclonifen, amitrole, clomazone, flumeturon, glyphosate and its salt, bialaphos, bilanaphos-sodium, glufosinate, glufosinate-P, glufosinate-ammonium, asulam, dinitroanilines (for example, benfluralin, butralin, dinitramine, ethalfluralin, fluchloralin, oryzalin, pendimethalin, prodiamine and trifluralin), phosphoramidate herbicides (for example, amiprophos, amiprophos-methyl and butamiphos), benzoic acid herbicides (for example, chlorthal and chlorthal-dimethyl), pyridines (for example, dithiopyr and thiazopyr), benzamides (for example, propyzamide and tebutam), chloroacetamides (for example, acetochlor, alachlor, butachlor, dimethachlor, dimethenamid, dimethenamid-P, metazachlor, metolachlor, metolachlor-S, pethoxamid, pretilachlor, propachlor, propisochlor and thenylchlor), oxyacetanilides (for example, flufenacet and mefenacet), acetanilides (for example, diphenamid, naproanilide and napropamide), tetrazolinones (for example, fentrazamide), anilofos, cafenstrole, fenoxasulfone, ipfencarbazone, piperophos, pyroxasulfone, chlorthiamid, dichlobenil, flupoxam, isoxaben, dinoseb, dinoterb, 4,6-dinitro-o-cresol (DNOC) and its salt, 2,4-D and it salt or ester, 2,4-DB and its salt or ester, aminopyralid and its salts (for example aminopyralid-tris(2-hydroxypropyl)ammonium) and esters of these, benazolin, benazolin-ethyl, chloramben and its salt or ester, chlomeprop, clopyralid and its salt or ester, dicamba and its salt or ester, dichlorprop and its salt or ester, dichlorprop-P and its salt or ester, fluroxypyr and its salt or ester, 2-methyl-4-chlorophenoxyacetic acid (MCPA) and its salt or ester, MCPA-thioethyl, 4-(2-methyl-4-chlorophenoxy)butyric acid (MCPB) and its salt or ester, mecoprop and its salt or ester, mecoprop-P and its salt or ester, picloram and its salt or ester, quinclorac, quinmerac, 2,3,6-trichlorobenzoic acid (TBA(2,3,6)) and its salt or ester, triclopyr and its salt or ester, aminocyclopyrachlor and its salt or ester, diflufenzopyr and its salt, naptalam and its salt, bromobutide, chlorflurenol, chlorflurenol-methyl, cinmethylin, cumyluron, dalapon, dazomet, difenzoquat, difenzoquat-methyl sulfate, dimethipin, disodium methanearsonate (DSMA), dymron, endothal and its salt, etobenzanid, flamprop, flamprop-isopropyl, flamprop-methyl, flamprop-M-isopropyl, flamprop-M-methyl, flurenol, flurenol-butyl, flurprimidol, fosamine, fosamine-ammonium, indanofan, indaziflam, maleic hydrazide, mefluidide, metam, methiozolin, methyl azide, methyl bromide, methyl-dymron, methyl iodide, MSMA, oleic acid, oxaziclomefone, pelargonic acid, pyributicarb, quinoclamine, triaziflam, tridiphane, and 6-chloro-3-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinol (CAS 499223-49-3) and its salt or ester. 
     Examples of the agent for controlling insect parasites of animals used in admixture or in combination include organic phosphate ester compounds, carbamate compounds, nereistoxin compounds, organochlorine compounds, pyrethroid compounds, benzoyl urea compounds, juvenile hormone-type compounds, molting hormone-type compounds, neonicotinoid compounds, nerve cell sodium channel blockers, insecticidal macrolactones, gamma-aminobutyric acid (GABA) antagonists, ryanodine receptor agonists, insecticidal ureas and the like. More desirable specific examples are dichlorvos, EPN, fenitrothion, fenamifos, prothiofos, profenofos, pyraclofos, chlorpyrifos-methyl, diazinon, trichlorfon, tetrachlorvinphos, bromofenofos, cythioate, fenthion and other organic phosphate ester compounds; methomyl, thiodicarb, aldicarb, oxamyl, propoxur, carbaryl, fenobucarb, ethiofencarb, fenothiocarb, pirimicarb, carbofuran, benfuracarb and other carbamate compounds; cartap, thiocyclam and other nereistoxin compounds; dicofol, tetradifon and other organochlorine compounds; allethrin, d•d-T allethrin, dl•d-T80 allethrin, pyrethrins, phenothrin, flumethrin, cyfluthrin, d•d-T80 prarethrin, phthalthrin, transfluthrin, resmethrin, cyphenothrin, pyrethrum extract, synepirin 222, synepirin 500, permethrin, tefluthrin, cypermethrin, deltamethrin, cyhalothrin, fenvalerate, fluvalinate, ethofenprox, silafluofen and other pyrethroid compounds; diflubenzuron, teflubenzuron, flufenoxuron, chlorfluazuron, lufenuron and other benzoyl urea compounds; methoprene and other juvenile hormone-type compounds; and chromafenozide and other molting hormone-type compounds. Examples of other compounds include amitraz, chlordimeform, fipronil, etoxazole, imidacloprid, clothianidin, thiamethoxam, acetamiprid, nitenpyram, thiacloprid, dinotefuran, spirodiclofen, pyriproxyfen, indoxacarb, spinosad, spinetoram, avermectin, milbemycin, metaflumizone, pyrafluprole, pyriprole, hydramethylnon, triazamate, sulfoxaflor, flupyradifurone, ivermectin, selamectin, moxidectin, doramectin, eprinomectin, milbemycin oxime, diethylcarbamazine citrate, deet, metoxadiazone, cyromazine, triflumuron, star anise oil, triclabendazole, flubendazole, fenbendazole, antimony sodium gluconate, levamisole hydrochloride, bithionol, dichlorophen, phenothiazine, piperazine carbon bisulfide, piperazine phosphate, piperazine adipate, piperazine citrate, melarsomine dihydrochloride, metyridine, santonin, pyrantel pamoate, pyrantel, praziquantel, febantel, emodepside, derquantel, monepantel, emamectin benzoate, cycloxaprid, and a compound represented by the following Formula (VI), or acid addition salts of these that are allowable as agricultural and veterinary chemicals. Examples of acid addition salts of these include hydrochloride salts, nitrate salts, sulfate salts, phosphate salts or acetate salts or the like. 
     [Synthesis Method of Compound of the Present Invention] 
     A compound represented by the following Formula (I-1) 
     
       
         
         
             
             
         
       
     
     may be obtained by reacting a compound represented by the following Formula (II-1) with a compound represented by ArCH2X [the definition of Ar, A, Y and R1 has the same meaning as the definition described above, and X represents a halogen atom or OTs, OMs and the like] in the presence or absence of a base. 
     
       
         
         
             
             
         
       
     
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction, and when the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol, propanol and isopropyl alcohol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but N,N-dimethylformamide and the like are preferably used. 
     The reaction may be performed usually at from 0° C. to 200° C., and it is preferred that reagents are added at from 20° C. to 40° C. and the reaction is performed at from 60° C. to 80° C. 
     The compound represented by Formula (II-1) may be obtained by reacting a compound represented by R1-C(═O)X, R1-C(═O)OC(═O)R1, R1C(═O)OR′ [X represents a halogen atom or OTs, OMs and the like, R′ represents a C1 to C6 alkyl group, and the definition of R1, Aand Y has the same meaning as the definition described above] and the like with a compound represented by in the following Formula (III) in the presence or absence of a base. 
     
       
         
         
             
             
         
       
     
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like as the base. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction. When the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol and propanol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, and water, either alone or in combination of two or more thereof, but toluene, N,N-dimethylformamide, acetonitrile, ethers, dichloromethane, chloroform and the like are preferably used. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 50° C. 
     The compound represented by Formula (II-1) may be obtained by reacting the compound represented by the Formula (III) with a carboxylic acid represented by R1-COOH [the definition of R1 has the same meaning as the definition described above] using a dehydration condensation agent in the presence or absence of a base, or may be obtained by performing the reaction using phosphorus pentaoxide, sulfuric acid, polyphosphoric acid, thionyl chloride, phosphorus oxychloride and oxalyl dichloride in the absence of a base. 
     It is possible to use a carbodiimide-based compound such as dicyclohexylcarbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and the like as the dehydration condensation agent. 
     When the reaction is performed in the presence of a base, it is possible to use, for example, a carbonate such as potassium carbonate or sodium carbonate and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction is preferably performed by using a solvent, and it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but N,N-dimethylformamide, acetonitrile, ethers, dichloromethane, chloroform and the like are preferably used. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 50° C. 
     The compound represented by Formula (I-1) may be obtained by reacting a compound represented by R1-C(═O)X, R1-C(═O)OC(═O)R1, R1C(═O)OR′ [X represents a halogen atom or OTs, OMs and the like, R′ represents a C1 to C6 alkyl group, and the definition of Ar, A, Y and R1 has the same meaning as the definition described above] and the like with a compound represented by the following Formula (IV) in the presence or absence of a base. 
     
       
         
         
             
             
         
       
     
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction. When a solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether, and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol, and propanol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, and water, either alone or in combination of two or more thereof, toluene, N,N-dimethylformamide, acetonitrile, ethers, dichloromethane, chloroform or the like is preferably used. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 50° C. The compound represented by Formula (I-1) may be obtained by reacting the above-described compound represented by Formula (IV) with a carboxylic acid represented by R1-COOH [the definition of R1—has the same meaning as the definition described above] using a dehydration condensation agent in the presence or absence of a base, or may be obtained by performing the reaction using phosphorus pentaoxide, sulfuric acid, polyphosphoric acid, thionyl chloride, phosphorus oxychloride and oxalyl dichloride in the absence of a base. 
     It is possible to use a carbodiimide-based compound such as dicyclohexylcarbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and the like as the dehydration condensation agent. 
     When the reaction is performed in the presence of a base, it is possible to use, for example, a carbonate such as potassium carbonate or sodium carbonate and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction is preferably performed by using a solvent, and it is possible to use, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but dichloromethane, chloroform or the like is preferably used. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 50° C. The compound represented by Formula (IV) may be obtained by reacting the above-described compound represented by Formula (III) with a compound represented by ArCH2X [the definition of Ar and X has the same meaning as the definition described above] in the presence or absence of a base. 
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride, a carbonate such as potassium carbonate or sodium carbonate, an alkali metal hydroxide such as potassium hydroxide and sodium hydroxide, tertiary amines such as triethylamine and 1,8-diazabicyclo[4.3.0]non-5-ene, and unsubstituted or substituent-containing pyridines, such as pyridine and 4-dimethylaminopyridine as the base. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction. When the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol and propanol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, and water, either alone or in combination of two or more thereof, but N,N-dimethylformamide, acetonitrile, ethers, dichloromethane, chloroform and the like is preferably used. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 80° C. 
     When Formula (I-1) is synthesized via Formula (II-1) from the compound represented by Formula (III), or when Formula (I-1) is synthesized via Formula (IV) from the compound represented by Formula (III), the reaction may be continuously performed without taking out Formula (II-1) or Formula (IV), or the reactions from Formula (III) to Formula (I-1) may be simultaneously performed in the same vessel. 
     
       
         
         
             
             
         
       
     
     The compound represented by Formula (I-2) may be obtained by reacting a compound represented by the following Formula (I-2a) with a compound represented by ArCH2X [the definition of Ar, A, Y and R2 has the same meaning as the definition described above, and X represents a halogen atom or OTs, OMs and the like] in the presence or absence of a base. 
     
       
         
         
             
             
         
       
     
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction, and when the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol, propanol and isopropyl alcohol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but N,N-dimethylformamide and the like are preferably used. 
     The reaction may be performed usually at from 0° C. to 200° C., and it is preferred that reagents are added at from 20° C. to 40° C. and the reaction is performed at from 60° C. to 80° C. 
     The compound represented by Formula (I-2a) may be obtained by reacting the above-described compound represented by Formula (III) with a compound represented by R2OC(═O)X (the definition of R2 and X has the same meaning as the definition described above) or represented by the following Formula (I-2b) in the presence or absence of a base. 
     
       
         
         
             
             
         
       
     
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction, and when the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol, propanol, and isopropyl alcohol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but acetonitrile, dichloromethane, and the like are preferably used. 
     The reaction may be performed usually at from 0° C. to 200° C., and is performed preferably at from 20° C. to 80° C. 
     The compound represented by Formula (I-2) may be obtained by reacting the above-described compound represented by Formula (IV) with a compound represented by R2OC(═O)X (the definition of R2 and X has the same meaning as the definition described above) or represented by the above-described Formula (I-2b) in the presence or absence of a base. 
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction, and when the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol, propanol, and isopropyl alcohol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but acetonitrile, dichloromethane, and the like are preferably used. 
     The reaction may be performed usually at from 0° C. to 200° C., and is performed preferably at from 20° C. to 80° C. 
     
       
         
         
             
             
         
       
     
     The compound represented by Formula (I-3) may be synthesized by acting a sulfurizing reagent on a compound (the definition of Ar, A, Y and R3 has the same meaning as the definition described above) represented by the following Formula (II-3a), which may be synthesized in the same manner as described in Formula (I-1), in the presence or absence of a base. 
     
       
         
         
             
             
         
       
     
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base, but potassium carbonate, sodium carbonate or the like is preferably used. 
     As the sulfurizing reagent, phosphorus pentasulfide, Lawesson&#39;s reagent, hydrogen sulfide and the like may be used. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction, and when the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol and propanol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but toluene, tetrahydrofuran, and the like are preferably used. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 80° C. 
     The compound represented by Formula (I-3) may be obtained by reacting a compound represented by the following Formula (II-3b) with a compound represented by ArCH2X [the definition of Ar, A, Y and R3 has the same meaning as the definition described above, and X represents a halogen atom or OTs, OMs and the like] in the presence or absence of a base. 
     
       
         
         
             
             
         
       
     
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction, and when the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol propanol, and isopropyl alcohol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but N,N-dimethylformamide is preferably used. 
     The reaction may be performed usually at from 0° C. to 200° C., and it is preferred that reagents are added at from 20° C. to 40° C. and the reaction is performed at from 60° C. to 80° C. 
     A compound represented by the following Formula (II-3b) may be synthesized by acting a sulfurizing reagent on a compound (the definition of A, Y and R3 has the same meaning as the definition described above) represented by the following Formula (II-3c), which may be synthesized in the same manner as described in Formula (II-1), in the presence or absence of a base. 
     
       
         
         
             
             
         
       
     
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base, but potassium carbonate, sodium carbonate or the like is preferably used. 
     As the sulfurizing reagent, phosphorus pentasulfide, Lawesson&#39;s reagent, hydrogen sulfide and the like may be used. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction, and when the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol and propanol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but toluene, N,N-dimethylformamide, acetonitrile, ethers, dichloromethane and chloroform are preferably used. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 80° C. 
     
       
         
         
             
             
         
       
     
     The compound represented by Formula (I-4) may be obtained by reacting a compound represented by the following Formula (II-4a), which may be synthesized in the same manner as described in Formula (I-3), with a compound represented by R4-NH2 (the definition of Ar, A, Y, R4 and R5 has the same meaning as the definition described above) 
     
       
         
         
             
             
         
       
     
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction, and when the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol, and propanol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but alcohols such as methanol, ethanol, and the like are preferably used. 
     The reaction, if performed in the presence of silver carbonate, copper carbonate and the like, progresses quickly, but may proceed without the compound. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 80° C. 
     The compound represented by Formula (I-4) may be obtained by reacting a compound represented by the following Formula (I-4b) or salts thereof with R4-X, R4-O—R4 and R4-OR′ (the definition of R4, R′, Ar, A, Y and R5 has the same meaning as the definition described above, and X represents a halogen atom) in the presence or absence of a base. 
     
       
         
         
             
             
         
       
     
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction. When a solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol and propanol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, and water, either alone or in combination of two or more thereof, but toluene, dimethylformamide, acetonitrile, ethers, dichloromethane, chloroform and the like are preferably used. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 50° C. 
     The compound represented by Formula (I-4b) may be obtained by reacting a compound represented by Formula (II-4a) with ammonia or an alcohol solution thereof, ammonium chloride and the like. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction. When the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol and propanol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, and water, either alone or in combination of two or more thereof, but alcohols such as methanol and ethanol are preferably used. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 50° C. 
     
       
         
         
             
             
         
       
     
     The compound represented by Formula (I-5) may be obtained by reacting a compound represented by the following Formula (II-5b) with R6-X (the definition of AR, A, Y, R6 and R7 has the same meaning as the definition described above, and X represents a halogen atom), R6-O—R6 or R6-OR′ (the definition of R′ has the same meaning as the definition described above) in the presence or absence of a base. 
     
       
         
         
             
             
         
       
     
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction. When the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol and propanol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, and water, either alone or in combination of two or more thereof, but toluene, N,N-dimethylformamide, acetonitrile, ethers, dichloromethane, and chloroform, and the like are preferably used. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 50° C. 
     When R6 represents —C(═O)R6a (R6a has the same meaning as described above), the compound represented by Formula (I-5) may be obtained by reacting the compound represented by Formula (II-5b) with a carboxylic acid represented by R6a-C(═O)OH (the definition of R6a has the same meaning as the definition described above) using a dehydration condensation agent in the presence or absence of a base, or may be obtained by performing the reaction using phosphorus pentaoxide, sulfuric acid, polyphosphoric acid, thionyl chloride, phosphorus oxychloride and oxalyl dichloride in the absence of a base. 
     It is possible to use a carbodiimide-based compound such as dicyclohexylcarbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and the like as the dehydration condensation agent. 
     When the reaction is performed in the presence of a base, it is possible to use, for example, a carbonate such as potassium carbonate or sodium carbonate and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction is preferably performed by using a solvent, and it is possible to use, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but dichloromethane and chloroform, and the like is preferably used. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 50° C. 
     When R6 represents CONR6eR6f (the definition of R6e and R6f has the same meaning as the definition described above, and R6e or R6f represents a hydrogen atom) or CSNR6gR6h (the definition of R6g and R6h has the same meaning as the definition described above, and R6g or R6h represents a hydrogen atom), the compound of Formula (I-5) may be obtained by reacting Formula (II-5b) with a compound represented by R″N═C═O (R″ represents a C1 to C6 alkyl group which may be substituted with a halogen atom, a C2 to C6 alkenyl group which may be substituted with a halogen atom, a C2 to C6 alkynyl group which may be substituted with a halogen atom, a (C1 to C4) alkoxy (C1 to C5) alkyl group, a (C1 to C4) alkylthio (C1 to C5) alkyl group, a substituted or unsubstituted (C6 to C10) aryl group, and a substituted or unsubstituted 5- to 10-membered heterocycle) in the presence or absence of a base. 
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction is preferably performed by using a solvent, and it is possible to use, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but nitriles such as acetonitrile are preferably used. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 80° C. 
     When R6 represents CONR6eR6f (the definition of R6e and R6f has the same meaning as the definition described above), the compound of Formula (I-5) may be obtained by reacting the above-described compound represented by Formula (II-5b) with a compound represented by the following Formula (II-5c) in the presence or absence of a base. 
     
       
         
         
             
             
         
       
     
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction is preferably performed by using a solvent, and it is possible to use, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but nitriles such as acetonitrile are preferably used. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 80° C. 
     The compound represented by Formula (II-5b) may be obtained by reacting the compound (the definition of Ar, A, Y and R7 has the same meaning as the definition described above) represented by Formula (II-5a), which may be synthesized in the same manner as described in Formula (I-3) with hydroxylamine or salts thereof in the presence or absence of a base. 
     
       
         
         
             
             
         
       
     
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction. When the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol and propanol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, and water, either alone or in combination of two or more thereof, but toluene, N,N-dimethylformamide, acetonitrile, ethers, dichloromethane, and chloroform, and the like are preferably used. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 80° C. 
     The compound represented by Formula (I-5) may also be obtained by reacting the compound represented by Formula (II-5a) with a compound represented by R6-ONH2 or salts thereof in the presence or absence of a base. 
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction. When the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol and propanol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, and water, either alone or in combination of two or more thereof, but alcohols such as methanol and ethanol are preferably used. 
     The reaction may be performed usually at from −80° C. to 100° C., and is performed preferably in a range from 20° C. to 80° C. 
     The reaction, if performed in the presence of silver carbonate, copper carbonate and the like, progresses quickly, but may proceed without the compound. 
     The compound represented by Formula(I-6) 
     
       
         
         
             
             
         
       
     
     [the definition of Ar, A, Y and Y1, Y2, Ry has the same meaning as the definition described above] may be obtained by reacting according to Phosphorus, sulfur, and silicon and the related elements (2006) 181, 2337-2344. 
     The compound represented by Formula (I-7) 
     
       
         
         
             
             
         
       
     
     [the definition of Ar, A, Y, n, Rz has the same meaning as the definition described above] may be obtained by reacting a compound represented by the following Formula (II-7a) with a compound represented by ArCH2X [the definition of Ar has the same meaning as the definition described above, and X represents a halogen atom or OTs, OMs and the like] in the presence or absence of a base. 
     
       
         
         
             
             
         
       
     
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction, and when the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol, propanol and isopropyl alcohol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but N,N-dimethylformamide and the like are preferably used. 
     The reaction may be performed usually at from 0° C. to 200° C., and it is preferred that reagents are added at from 20° C. to 40° C. and the reaction is performed at from 60° C. to 80° C. 
     The compound represented by Formula (II-7a) may be obtained by reacting a compound represented by (II-7b) [X represents a halogen atom, and the definition of Rz has the same meaning as the definition described above] with a compound represented by in the following Formula (III) in the presence or absence of a base. 
     
       
         
         
             
             
         
       
     
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction, and when the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol, propanol and isopropyl alcohol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but N,N-dimethylformamide and the like are preferably used. 
     The reaction may be performed usually at from 0° C. to 200° C., and it is preferred that reagents are added at from 20° C. to 40° C. and the reaction is performed at from 60° C. to 80° C. 
     The compound represented by Formula (I-7) may be obtained by reacting a compound represented by (II-7b) [X represents a halogen atom, and the definition of Rz has the same meaning as the definition described above] with a compound represented by in the following Formula (IV) in the presence or absence of a base. 
     When the reaction is performed in the presence of a base, it is possible to use, for example, an alkali metal hydride such as sodium hydride and the like, a carbonate such as potassium carbonate or sodium carbonate and the like, an alkali metal hydroxide such as potassium hydroxide, sodium hydroxide and the like, tertiary amines such as triethylamine, 1,8-diazabicyclo[4.3.0]non-5-ene and the like, and unsubstituted or substituent-containing pyridines, such as pyridine, 4-dimethylaminopyridine and the like, as the base. 
     The reaction may be performed without a solvent or using a solvent which does not affect the reaction, and when the solvent is used, it is possible to use solvents such as, for example, amides such as N,N-dimethylformamide and N,N-dimethylacetamide, nitriles such as acetonitrile, sulfoxides such as dimethyl sulfoxide, ethers such as diethyl ether and tetrahydrofuran, esters such as ethyl acetate and butyl acetate, aromatic hydrocarbons such as benzene, xylene and toluene, alcohols such as methanol, ethanol, propanol and isopropyl alcohol, ketones such as acetone and methyl ethyl ketone, aliphatic hydrocarbons such as hexane, heptane and octane, and halogen hydrocarbons such as dichloromethane, chloroform, chlorobenzene and dichlorobenzene, either alone or in combination of two or more thereof, but N,N-dimethylformamide and the like are preferably used. 
     The reaction may be performed usually at from 0° C. to 200° C., and it is preferred that the reaction is performed at from 0° C. to 80° C. 
     EXAMPLES 
     Subsequently, the present invention will be specifically described with reference to Examples, but the present invention is not limited to the Examples. 
     Reference Example 1 
     N-[1-((6-chloropyridine-3-yl)methyl)pyridine-2(1H)-ylidene-2,2,2-trifluoroacetamide (Compound P212) 
     (1) 25 g (270 mmol) of 2-aminopyridine was dissolved in 200 ml of anhydrous dichloromethane, 41 ml (30 g, 300 mmol) of triethylamine was added thereto, and the mixture was cooled to 0° C. 38 ml (57 g, 270 mmol) of anhydrous trifluoroacetic acid was added dropwise thereto over 15 minutes, and the resulting mixture was stirred at room temperature for 2 hours. After the reaction was completed, the reaction solution was injected into about 100 ml of iced water, and the mixture was stirred for 10 minutes. The mixture was transferred to a separatory funnel to perform liquid separation, and the organic layer was washed twice with 150 ml of water and twice with 150 ml of a 1% HCl aqueous solution, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 36 g (yield 71%) of 
     2,2,2-trifluoro-N-(pyridin-2(1H)-ylidene)acetamide 
     1H-NMR (CDCl3, δ, ppm): 7.20 (1H, ddd), 7.83 (1H, td), 8.20 (1H, d), 8.35 (1H, d), 10.07 (1H, brs) 
     13C-NMR (CDCl3, δ, ppm): 115.3, 115.5 (q), 121.6, 139.1, 147.9, 149.5, 155.3 (q) 
     MS:m/z=191 (M+H) 
     (2) 20 g (126 mmol) of 2-chloro 5-chloromethyl pyridine was dissolved in 200 ml of anhydrous acetonitrile, 24 g (126 mmol) of 2,2,2-trifluoro-N-(pyridin-2(1H)-ylidene)acetamide obtained by the above-described method and 21 g (151 mmol) of potassium carbonate were added thereto, and the resulting mixture was heated and refluxed for 6 hours, and then stirred at room temperature for 10 hours. After the reaction was completed, the reaction solution was filtered and the filtrate was concentrated under reduced pressure. Diethyl ether was added thereto for crystallization, and the crystals thus obtained were collected and washed well with diethyl ether and water. The crystals thus obtained were dried under reduced pressure at 60° C. for 1 hour to obtain the subject material. Amount obtained 26 g (yield 66%). 
     1H-NMR (CDCl3, δ, ppm): 5.57 (2H, s), 6.92 (1H, td), 7.31 (1H, d), 7.80 (1H, td), 7.87 (1H, dd), 7.99 (1H, dd), 8.48 (2H, m) 
     13C-NMR (CDCl3, δ, ppm): 53.8, 115.5, 117.2 (q), 122.1, 124.7, 130.0, 139.2, 140.0, 142.5, 149.7, 151.8, 158.9, 163.5 (q) 
     MS: m/z=316(M+H) 
     (3) Powder X-Ray Crystal Analysis 
     In the powder X-ray diffraction, measurement was performed under the following conditions. 
     Device name: RINT-2200 (Rigaku Corporation) 
     X-ray: Cu-Kα (40 kV, 20 mA) 
     Scanning range: 4 to 40°, sampling width: 0.02° and scanning rate: 1°/min 
     The results are as follows. 
     Diffraction angle (2θ) 8.7°, 14.2°, 17.5°, 18.3°, 19.8°, 22.4°, 30.9° and 35.3° 
     (4) Differential Scanning Calorimetry (DSC) 
     In the differential scanning calorimetry, measurement was performed under the following conditions. 
     Device name: DSC-60 
     Sample cell: aluminum 
     Temperature range: 50° C. to 250° C. (heating rate: 10° C./min) 
     As a result, the melting point was observed at 155° C. to 158° C. 
     Another Method of Reference Example 1 
     3.00 g (18.6 mmol) of 2-chloro-5-chloromethyl pyridine was dissolved in 20 ml of anhydrous DMF, 1.75 g (18.6 mmol) of 2-aminopyridine was added thereto, and the resulting mixture was stirred at 80° C. for 8 hours and at room temperature for 5 hours. After the reaction was completed, DMF was distilled off under reduced pressure, acetonitrile was added thereto to precipitate a solid, and the solid was collected, washed well with acetonitrile and dried to obtain 2.07 g (yield 44%) of 1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride. 
     1H-NMR (DMSO-d6, δ, ppm): 5.65 (2H, s), 6.96 (1H, t), 7.23 (1H, m), 7.57 (1H, d), 7.80 (1H, m), 7.91 (1H, m), 8.28 (1H, m), 8.49 (1H, d), 9.13 (2H, brs) 
     50 mg (0.20 mmol) of the 1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride obtained by the above-described method was dissolved in 5 ml of anhydrous dichloromethane, 122 mg (1.00 mmol) of DMAP and 50 mg (0.24 mmol) of anhydrous trifluoroacetic acid were added thereto in sequence under ice cold conditions, and the resulting mixture was stirred at room temperature for 1 hour. After the reaction was completed, the reaction solution was diluted with dichloromethane, washed with 1% hydrochloric acid, and then dried over anhydrous magnesium sulfate. Dichloromethane was distilled off under reduced pressure to obtain the subject material. Amount obtained 42 mg (yield 67%). NMR was the same as that of the above-described method. 
     Reference Example 2 
     2,2-dibromo-N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-acetamide (Compound P241) 
     200 mg (0.78 mmol) of the 1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride obtained by the method described in another method of Reference Example 1, 238 mg (1.95 mmol) of DMAP and 224 mg (1.17 mmol) of EDC-HCl were dissolved in 10 ml of anhydrous dichloromethane, 101 μl (202 mg, 1.17 mmol) of dibromoacetic acid was added thereto, and the resulting mixture was stirred at room temperature overnight. After the reaction was completed, the reaction solution was diluted with dichloromethane, washed once with water and twice with a 1% HCl aqueous solution, and then dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the subject material. Amount obtained 50 mg (yield 15%) 
     1H-NMR (CDCl3, δ, ppm): 5.56 (2H, s), 5.99 (1H, s), 6.78 (1H, td), 7.33 (1H, d), 7.69 (1H, td), 7.76 (1H, dd), 7.93 (1H, dd), 8.39 (1H, d), 8.50 (1H, d) 
     13C-NMR (CDCl3, δ, ppm): 44.6, 53.1, 113.7, 121.9, 124.8, 130.1, 138.2, 139.7, 141.2, 149.5, 152.0, 159.4, 172.2 
     Reference Example 3 
     N-[1-((6-chloro-5-fluoropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide (Compound P227) 
     4.00g (27.6 mmol) of 2-chloro-3-fluoro-5-methyl pyridine was dissolved in 80 ml of carbon tetrachloride, 7.37g (41.4 mmol) of N-bromosuccinimide and 20 mg of benzoyl peroxide were added thereto, and the resulting mixture was heated and refluxed overnight. After the reaction was completed, the reaction solution was returned to room temperature, concentrated under reduced pressure and purified by silica gel column chromatography (hexane:ethyl acetate=19:1) to obtain 3.06 g (yield 51%) of 5-(bromomethyl)-2-chloro-3-fluoropyridine. 
     1H-NMR (CDCl3, δ, ppm): 4.45 (2H, s), 7.54 (1H, td), 8.23 (1H, s) 
     50 mg (0.22 mmol) of the 5-(bromomethyl)-2-chloro-3-fluoropyridine obtained by the aforementioned method was dissolved in 5 ml of anhydrous acetonitrile, 42 mg (0.22 mmol) of 2,2,2-trifluoro-N-(pyridin-2(1H)-ylidene)acetamide obtained by the method described in (1) of Reference Example 1 and 36 mg (0.26 mmol) of potassium carbonate were added thereto in sequence, and the resulting mixture was heated and refluxed for 7 hours. After the reaction was completed, the reaction solution was returned to room temperature to filter insoluble materials, and the filtrate was concentrated under reduced pressure. Diethyl ether was added thereto to precipitate a solid, and thus the solid was collected, washed with diethyl ether, and then dried under reduced pressure in a desiccator to obtain the subject material. Amount obtained 29 mg (yield 40%). 
     1H-NMR (CDCl3, δ, ppm): 5.54 (2H, s), 6.89 (1H, td), 7.76 (1H, dd), 7.80 (1H, td), 7.85 (1H, d), 8.29 (1H, d), 8.57 (1H, d) 
     Reference Example 4 
     N-[1-((6-fluoropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide (Compound P229) 
     500 mg (4.50 mmol) of 2-fluoro-5-methyl pyridine was dissolved in 50 ml of carbon tetrachloride, 1.20 g (6.76 mmol) of N-bromosuccinimide and 20 mg of benzoyl peroxide were added thereto, and the resulting mixture was heated and refluxed for 2.5 hours. After the reaction was completed, the reaction solution was returned to room temperature, and the solvent was distilled off under reduced pressure and purified by silica gel column chromatography (hexane:ethyl acetate=19:1) to obtain 300 mg (yield 35%) of 5-bromomethyl-2-fluoropyridine. 
     57 mg (0.30 mmol) of the 5-bromomethyl-2-fluoropyridine obtained by the aforementioned method was dissolved in 10 ml of anhydrous acetonitrile, 57 mg (0.30 mmol) of 2,2,2-trifluoro-N-(pyridin-2(1H)-ylidene)acetamide synthesized by the method described in (1) of Reference Example 1 and 69 mg (0.50 mmol) of potassium carbonate were added thereto in sequence, and the resulting mixture was heated and refluxed for 6 hours. After the reaction was completed, the reaction solution was returned to room temperature to filter insoluble materials, and the filtrate was concentrated under reduced pressure. The filtrate was purified by silica gel column chromatography (hexane:ethyl acetate=1:1→3:1) to obtain the subject material. Amount obtained 21 mg (yield 23%) 
     1H-NMR (CDCl3, δ, ppm): 5.56 (2H, s), 6.89 (1H, td), 6.94 (1H, d), 7.79 (1H, td), 7.87 (1H, d), 8.03 (1H, m), 8.31 (1H, s), 8.54 (1H, d) 
     MS: m/z=300(M+H) 
     Reference Example 5 
     N-[1-((6-bromopyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2, 2,2-trifluoroacetamide (Compound P231) 
     500 mg (2.92 mmol) of 2-bromo-5-methylpyridine was dissolved in 15 ml of carbon tetrachloride, 623 mg (3.50 mmol) of N-bromosuccinimide and 10 mg of benzoyl peroxide were added thereto, and the resulting mixture was heated and refluxed for 19 hours. After the reaction was completed, the reaction solution was returned to room temperature, concentrated under reduced pressure and purified by silica gel column chromatography (hexane:ethyl acetate=19:1) to obtain 143 mg (yield 20%) of 2-bromo-5-bromomethylpyridine. 
     1H-NMR (CDCl3, δ, ppm): 4.42 (2H, s), 7.47 (1H, d), 7.59 (1H, dd), 8.38 (1H, d) 
     70 mg (0.28 mmol) of the 2-bromo-5-bromomethylpyridine obtained by the aforementioned method was dissolved in 10 ml of anhydrous acetonitrile, 54 mg (0.28 mmol) of 2,2,2-trifluoro-N-(pyridin-2(1H)-ylidene)acetamide synthesized by the method described in (1) of Reference Example 1 and 46 mg (0.34 mmol) of potassium carbonate were added thereto in sequence, and the resulting mixture was heated and refluxed for 6 hours. After the reaction was completed, the reaction solution was returned to room temperature to filter insoluble materials, and the filtrate was concentrated under reduced pressure. Diethyl ether was added thereto to precipitate a solid, and thus the solid was collected, washed with diethyl ether, and then dried under reduced pressure in a desiccator to obtain the subject material. Amount obtained 81 mg (yield 82%). 
     1H-NMR (CDCl3, δ, ppm): 5.52 (2H, s), 6.88 (1H, t), 7.48 (1H, d), 7.78 (2H, m), 7.84 (1H, d), 8.44 (1H, d), 8.53 (1H, d) 
     MS:m/z=360(M+H) 
     Reference Example 6 
     2-chloro-N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-acetamide (Compound P236) 
     70 mg (0.27 mmol) of the 1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride obtained by the method described in another method of Reference Example 1 was dissolved in 4 ml of anhydrous dichloromethane, 82 mg (0.67 mmol) of DMAP, 25 mg (0.27 mmol) of chloroacetic acid and 62 mg (0.32 mmol) of EDC-HCl were added thereto in sequence, and the resulting mixture was stirred at room temperature overnight. After the reaction was completed, dichloromethane was added thereto to dilute the mixture, and the mixture was washed with water and a 1% HCl aqueous solution, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the subject material. Amount obtained 4 mg (yield 5%). 
     1H-NMR (CDCl3, δ, ppm): 4.17 (2H, s), 5.46 (2H, s), 6.64 (1H, td), 7.31 (1H, d), 7.60 (1H, td), 7.64 (1H, dd), 7.80 (1H, dd), 8.32 (1H, d), 8.45 (1H, d) 
     MS:m/z=296(M+H) 
     Reference Example 7 
     N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2 (1H)-ylidene]-2,2-difluoroacetamide (Compound P238) 
     400 mg (4.26 mmol) of 2-aminopyridine was dissolved in 10 ml of anhydrous dichloromethane, 322 μl (490 mg, 5.11 mmol) of difluoroacetic acid, 982 mg (5.10 mmol) of EDC-HCl and 622 mg (5.11 mmol) of DMAP were added thereto, and the resulting mixture was stirred at room temperature for 61 hours. After the reaction was completed, the reaction solution was diluted with dichloromethane, washed once with water and twice with a 1% HCl aqueous solution, and then dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 102 mg (yield 14%) of 2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide. 
     1H-NMR (CDCl3, δ, ppm): 6.03 (1H, t), 7.15 (1H, m), 7.78 (1H, td), 8.20 (1H, d), 8.34 (1H, dd), 8.72 (1H, br s) 
     100 mg (0.58 mmol) of the 2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide obtained by the aforementioned method was dissolved in 10 ml of anhydrous acetonitrile, 94 mg (0.58 mmol) of 2-chloro-5-chloromethylpyridine was dissolved in 5 ml of anhydrous acetonitrile and added thereto, and subsequently, 84 mg (0.63 mmol) of potassium carbonate was added thereto and the resulting mixture was heated and refluxed for 140 minutes. After the reaction was completed, the reaction solution was returned to room temperature to filter off insoluble materials, and the filtrate was concentrated under reduced pressure. Ether was added thereto to precipitate a solid, and thus the solid was collected and dried well to obtain the subject material. Amount obtained 63 mg (yield 37%). 
     1H-NMR (CDCl3, δ, ppm): 5.52 (2H, s), 5.90 (1H, t), 6.79 (1H, td), 7.33 (1H, d), 7.71 (1H, m), 7.77 (1H, dd), 7.85 (1H, dd), 8.45 (1H, d), 8.50 (1H, d) 
     13C-NMR (DMSO-d6, δ, ppm): 53.0, 111.0 (t), 115.2, 120.7, 124.7, 131.7, 140.6, 141.6, 143.2, 150.4, 150.9, 158.3, 169.4 (t) 
     MS:m/z=298(M+H) 
     Reference Example 8 
     2-chloro-N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2-difluoroacetamide (Compound P239) 
     200 mg (2.13 mmol) of 2-aminopyridine was dissolved in 5 ml of dichloromethane, 491 mg (2.55 mol) of EDC-HCl, 311 mg (2.55 mmol) of DMAP and 187 μl (2.23 mmol, 290 mg) of chlorodifluoroacetic acid were added thereto in sequence, and the resulting mixture was stirred overnight. After the reaction was completed, the reaction solution was diluted with dichloromethane, washed with water and 1% hydrochloric acid, and then dried over anhydrous magnesium sulfate to obtain 105 mg (yield 24%) of 2-chloro-2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide. 
     1H-NMR (CDCl3, δ, ppm): 7.19 (1H, dd), 7.82 (1H, m), 8.18 (1H, d), 8.36 (1H, d), 9.35 (1H, brs) 
     53 mg (0.33 mmol) of 2-chloro-5-chloromethyl pyridine dissolved in 6 ml of anhydrous acetonitrile was added to 68 mg (0.33 mmol) of the 2-chloro-2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide synthesized by the aforementioned method, and subsequently, 50 mg (0.36 mmol) of potassium carbonate was added thereto and the resulting mixture was heated and refluxed for 1 hour. After the reaction was completed, the reaction solution was returned to room temperature and then concentrated under reduced pressure. Diethyl ether was added thereto to precipitate a solid, and thus the solid was collected and dried to obtain the subject material. Amount obtained 49 mg (yield 45%). 
     1H-NMR (CDCl3, δ, ppm): 5.56 (2H, s), 6.92 (1H, t), 7.33 (1H, d), 7.82 (1H, m), 7.91 (1H, dd), 8.02 (1H, d), 8.45 (1H, d), 8.48 (1H, d) 
     13C-NMR (CDCl3, δ, ppm): 53.8, 115.2, 120.1 (t), 122.1, 124.8, 139.0, 140.0, 142.3, 150.0, 151.9, 159.1, 159.1, 165.8 (t) 
     MS:m/z=332(M+H) 
     Reference Example 9 
     2,2,2-trichloro-N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-acetamide (Compound P235) 
     70 mg (0.27 mmol) of the 1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride obtained by the method described in another method of Reference Example 1 was dissolved in 4 ml of anhydrous dichloromethane, 94 μl (0.68 mmol, 68 mg) of triethylamine and 33 μg (0.27 mmol, 49 mg) of trichloroacetyl chloride were added thereto in sequence, and the resulting mixture was stirred at room temperature for 1 hour. After the reaction was completed, water was added thereto to stop the reaction and liquid separation was performed with dichloromethane and water. The organic layer was washed once with water and twice with 1% hydrochloric acid, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. Diethyl ether was added thereto to precipitate a solid, and thus the solid was collected and dried to obtain the subject material. Amount obtained 61 mg (yield 62%). 
     1H-NMR (CDCl3, δ, ppm): 5.59 (2H, s), 6.86 (1H, t), 7.32 (1H, d), 7.78 (1H, td), 7.91 (2H, m), 8.43 (1H, d), 8.50 (1H, d) 
     MS:m/z=364(M+H) 
     Reference Example 10 
     N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,3,3,3-pentafluoropropanamide (Compound P242) 
     300 mg (3.19 mmol) of 2-aminopyridine was dissolved in 15 ml of anhydrous dichloromethane, 919 mg (4.78 mol) of EDC-HCl, 583 mg (4.78 mmol) of DMAP and 397 μl (628 mg, 3.83 mmol) of pentafluoropropionic acid were added thereto in sequence, and the resulting mixture was stirred at room temperature overnight. After the reaction was completed, the reaction solution was diluted with dichloromethane, washed once with water and twice with 1% hydrochloric acid, and then dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 85 mg (yield 11%) of 2,2,3,3,3-pentafluoro-N-(pyridin-2(1H)-ylidene)propanamide. 
     52 mg (0.32 mmol) of 2-chloro-5-chloromethylpyridine dissolved in 8 ml of anhydrous acetonitrile and 49 mg (0.35 mmol) of potassium carbonate were added to 77 mg (0.32 mmol) of the 2,2,3,3,3-pentafluoro-N-(pyridin-2(1H)-ylidene)propanamide obtained by the aforementioned method, and the resulting mixture was heated and refluxed for 11 hours. After the reaction was completed, the reaction solution was returned to room temperature to filter insoluble materials, and the filtrate was concentrated under reduced pressure. The filtrate was purified by silica gel column chromatography (hexane:ethyl acetate=1:3) to obtain the subject material. Amount obtained 12 mg (yield 10%). 
     1H-NMR (CDCl3, δ, ppm): 5.56 (2H, s), 6.90 (1H, td), 7.32 (1H, d), 7.79 (2H, m), 7.84 (1H, d), 8.43 (1H, d), 8.56 (1H, d) 
     MS:m/z=366(M+H) 
     Reference Example 11 
     N-[1-((2-chloropyrimidin-5-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide (Compound P243) 
     1.04 g (8.13 mmol) of 2-chloro-5-methyl pyrimidine was dissolved in 30 ml of carbon tetrachloride, 1.73 g (9.75 mmol) of N-bromosuccinimide and 20 mg of benzoyl peroxide were added thereto, and the resulting mixture was heated and refluxed for 6 hours. After the reaction was completed, the reaction solution was returned to room temperature, concentrated under reduced pressure and purified by silica gel column chromatography (hexane:ethyl acetate=3:1) to obtain 641 mg (yield 38%) of 5-bromomethyl-2-chloropyridine. 
     1H-NMR (CDCl3, δ, ppm): 4.42 (2H, s), 8.66 (2H, s) 
     104 mg (0.50 mmol) of the 5-bromomethyl-2-chloropyridine obtained by the aforementioned method was dissolved in 6 ml of anhydrous acetonitrile, 96 mg (0.50 mmol) of 2,2,2-trifluoro-N-(pyridin-2(1H)-ylidene)acetamide obtained by the method described in (1) of Reference Example 1 and 76 mg (0.55 mmol) of potassium carbonate were added thereto, and the resulting mixture was heated and refluxed for 1 hour. After the reaction was completed, the reaction solution was returned to room temperature to filter off insoluble materials, and the filtrate was concentrated under reduced pressure. Diethyl ether was added thereto to precipitate a solid, and thus the solid was collected, washed with diethyl ether, and then dried under reduced pressure in a desiccator to obtain the subject material. Amount obtained 92 mg (yield 58%) 
     1H-NMR (CDCl3, δ, ppm): 5.54 (2H, s), 6.98 (1H, m), 7.87 (1H, m), 8.18 (1H, m), 8.48 (1H, m), 8.83 (2H, m) 
     13C-NMR (CDCl3, δ, ppm): 60.0, 115.6, 117.1 (q), 122.1, 127.5, 139.2, 142.9, 158.8, 160.3 (2C), 161.4, 163.8 (q) 
     MS:m/z=317(M+H) 
     Compounds P213 to P226, P228, P230, P232 to P234, P240 and P244 described in the Tables 1 and 2 were obtained in the same manner as in Reference Examples 1 to 11. 
     Synthetic Example 1 
     2,2-difluoro-N-[1-((6-fluoropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]acetamide (Compound 3-3) 
     
       
         
         
             
             
         
       
     
     (1) 400 mg (4.26 mmol) of 2-aminopyridine was dissolved in 10 ml of anhydrous dichloromethane, 322 μl (490 mg, 5.11 mmol) of difluoroacetic acid, 982 mg (5.10 mmol) of EDC-HCl and 622 mg (5.11 mmol) of DMAP were added thereto, and the resulting mixture was stirred at room temperature for 61 hours. After the reaction was completed, the reaction solution was diluted with dichloromethane, washed once with water and twice with a 1% HCl aqueous solution, and then dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 102 mg (yield 14%) of 2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide. 
     1H-NMR (CDCl3, δ, ppm): 6.03 (1H, t), 7.15 (1H, m), 7.78 (1H, td), 8.20 (1H, d), 8.34 (1H, dd), 8.72 (1H, brs) 
     (2) 128 mg (0.75 mmol) of 5-bromomethyl-2-fluoropyridine was dissolved in 3 ml of anhydrous DMF, 116 mg (0.68 mmol) of 2,2-difluoro-N-[pyridin-2(1H)-ylidene]acetamide was dissolved in 3 ml of anhydrous DMF and added thereto, and subsequently, 103 mg (0.75 mmol) of potassium carbonate was added thereto and the resulting mixture was stirred at 65° C. for 2 hours. After the reaction was completed, the reaction solution was returned to room temperature, and ethyl acetate and water were added thereto to perform liquid separation. The organic layer was washed with 1% hydrochloric acid, then dried over anhydrous magnesium sulfate and concentrated under reduced pressure. A small amount of hexane and diethyl ether were added thereto to precipitate crystals, and thus the crystals were collected and dried to obtain the subject material. Amount obtained 50 mg (yield 26%). 
     Synthetic Example 2 
     N-[1-((6-chloropyridin-3-yl)methyl)pyrimidin-2(1H)-ylidene]-2,2,2-trifluoroacetamide (Compound 190-2) 
     
       
         
         
             
             
         
       
     
     (1) 300 mg (1.86 mmol) of 2-chloro-5-chloromethylpyridine was dissolved in 6 ml of anhydrous DMF, 118 mg (1.24 mmol) of 2-aminopyrimidine was added thereto, and the resulting mixture was stirred at 80° C. for 8 hours. After the reaction was completed, the reaction solution was returned to room temperature to distill off DMF under reduced pressure. Diethyl ether was added thereto, and thus crystallization occurred on the wall surface of an eggplant flask. Diethyl ether was removed by decantation and dried well to obtain 1-((6-chloropyridin-3yl)methyl)pyrimidin-2(1H)-imine hydrochloride. Amount obtained 107 mg (yield 34%) 
     (2) 71 mg (0.27 mmol) of the 1-((6-chloropyridin-3-yl)methyl)pyrimidin-2(1H)-imine hydrochloride obtained by the aforementioned method was suspended in 5 ml of anhydrous dichloromethane, 114 l (0.83 mmol, 83 mg) of triethylamine and 53 μl (0.38 mmol) of trifluoroacetic anhydride were added thereto in sequence, and the resulting mixture was stirred at room temperature for 2 hours. After the reaction was completed, dichloromethane and water were added to the reaction solution to perform liquid separation, and the organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. A small amount of diethyl ether was added thereto to precipitate crystals, and thus the crystals were collected, washed with a small amount of diethyl ether, and then dried to obtain the subject material. Amount obtained 24 mg (yield 28%) 
     Synthetic Example 3 
     2,2,2-trifluoroethyl-[1-((6-chloropyridin-3-yl)methyl)pyridin-(2H)-ylidene]carbamate (Compound 1-17) 
     
       
         
         
             
             
         
       
     
     (1) 3.00 g (18.6 mmol) of 2-chloro-5-chloromethylpyridine was dissolved in 20 ml of anhydrous DMF, 1.75 g (18.6 mmol) of 2-aminopyridine was added thereto, and the resulting mixture was stirred at 80° C. for 8 hours and at room temperature for 5 hours. After the reaction was completed, DMF was distilled off under reduced pressure, acetonitrile was added thereto to precipitate a solid, and the solid was collected, washed well with acetonitrile and then dried to obtain 2.07 g (yield 44%) of 1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride. 
     1H-NMR (DMSO-d6, δ, ppm): 5.65 (2H, s), 6.96 (1H, t), 7.23 (1H, m), 7.57 (1H, d), 7.80 (1H, m), 7.91 (1H, m), 8.28 (1H, m), 8.49 (1H, d) 
     (2) 10 ml of anhydrous acetonitrile was added to 150 mg (0.66 mmol) of the 1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride obtained by the aforementioned method, 177 mg (0.66 mmol) of 4-nitrophenyl(2,2,2-trifluoroethyl)carbamate and 200 mg (1.46 mmol) of potassium carbonate were added, and the resulting mixture was stirred at 50° C. for 2 hours. After the reaction was completed, the reaction solution was returned to room temperature to filter off insoluble materials, and the filtrate was concentrated under reduced pressure. Dichloromethane and water were added thereto to perform liquid separation, and the organic layer was washed with 1% hydrochloric acid, then dried over anhydrous magnesium sulfate and concentrated under reduced pressure. A small amount of diethyl ether was added thereto to precipitate crystals, and thus the crystals were collected and dried well to obtain the subject material. Amount obtained 48 mg (yield 21%) 
     Synthetic Example 4 
     N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroethanethioamide (Compound 1-20) 
     
       
         
         
             
             
         
       
     
     (1) 25 g (270 mmol) of 2-aminopyridine was dissolved in 200 ml of anhydrous dichloromethane, 41 ml (30 g, 300 mmol) of triethylamine was added thereto, and the mixture was cooled to 0° C. 38 ml (57 g, 270 mmol) of anhydrous trifluoroacetic acid was added dropwise thereto over 15 minutes, and the resulting mixture was stirred at room temperature for 2 hours. After the reaction was completed, the reaction solution was injected into about 100 ml of iced water, and the mixture was stirred for 10 minutes. The mixture was transferred to a separatory funnel to perform liquid separation, and the organic layer was washed twice with 150 ml of water and twice with 150 ml of a 1% HCl aqueous solution, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 36 g (yield 71%) of 2,2,2-trifluoro-N-(pyridin-2(1H)-ylidene)acetamide. 
     1H-NMR (CDCl3, δ, ppm): 7.20 (1H, m), 7.83 (1H, m), 8.20 (1H, d), 8.35 (1H, d), 10.07 (1H, brs) 
     13C-NMR (CDCl3, δ, ppm): 115.3, 115.5 (q), 121.6, 139.1, 147.9, 149.5, 155.3 (q) 
     (2) 20 g (126 mmol) of 2-chloro 5-chloromethylpyridine was dissolved in 200 ml of anhydrous acetonitrile, 24 g (126 mmol) of 2,2,2-trifluoro-N-(pyridin-2(1H)-ylidene)acetamide obtained by the above-described method and 21 g (151 mmol) of potassium carbonate were added thereto, and the resulting mixture was heated and refluxed for 6 hours, and then stirred at room temperature for 10 hours. After the reaction was completed, the reaction solution was filtered and the filtrate was concentrated under reduced pressure. Diethyl ether was added thereto for crystallization, and the crystals thus obtained were collected and washed well with diethyl ether and water. The crystals thus obtained were dried under reduced pressure at 60° C. for 1 hour to obtain N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide. Amount obtained 26 g (yield 66%). 
     1H-NMR (CDCl3, δ, ppm): 5.57 (2H, s), 6.92 (1H, td), 7.31 (1H, d), 7.80 (1H, td), 7.87 (1H, dd), 7.99 (1H, dd), 8.48 (2H, m) 
     13C-NMR (CDCl3, δ, ppm): 53.8, 115.5, 117.2 (q), 122.1, 124.7, 130.0, 139.2, 140.0, 142.5, 149.7, 151.8, 158.9, 163.5 (q) 
     MS:m/z=316(M+H) 
     (3) 180 ml of toluene was added to 16.3 g (36.7 mmol) of phosphorus pentasulfide, 6.72 g (63.4 mmol) of sodium carbonate was added thereto and the resulting mixture was stirred at room temperature for 5 minutes. 20.0 g (63.4 mmol) of the N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide obtained by the above-described method was added thereto, and the resulting mixture was stirred at 50° C. for 19 hours. 150 ml of ethyl acetate was added to the reaction solution, the resulting mixture was stirred at 50° C. for 10 minutes, then insoluble materials were filtered off, and 250 ml of ethyl acetate was used to wash the mixture. The mixture was transferred to a separatory funnel, washed therein with 300 ml of a saturated sodium bicarbonate water and 200 ml of a saturated saline solution, and then concentrated under reduced pressure. 200 ml of water added thereto to precipitate crystals. 
     The mixture was stirred at room temperature for 1 hour, and then the crystals were collected, subjected to slurry washing twice with 150 ml of water and twice with 150 ml of hexane, and dried at 60° C. under reduced pressure for 2 hours to obtain the subject material. Amount obtained 19.5 g (yield 94%). 
     1H-NMR (CDCl3, δ, ppm): 5.48 (2H, s), 7.12 (1H, td), 7.34 (1H, d), 7.77 (1H, dd), 7.96 (1H, m), 8.05 (1H, dd), 8.45 (1H, d), 8.56 (1H, d) 
     MS:m/z=332(M+H) 
     Synthetic Example 5 
     N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoro-N′-methylacetimidamide (Compound 1-42) 
     
       
         
         
             
             
         
       
     
     150 mg (0.45 mmol) of the N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroethanethioamide synthesized by the method in Synthetic Example 4 was dissolved in 5 ml of methanol, 105 μl (42 mg, 1.36 mmol) of methylamine (40% methanol solution) and 124 mg (0.45 mmol) of silver carbonate were added thereto, and the resulting mixture was stirred at 50° C. for 1 hour. After the reaction was completed, the reaction solution was returned to room temperature and subjected to suction filtration by using celite to remove insoluble materials. Ethyl acetate and water were added thereto to perform liquid separation, and the organic layer was dried over anhydrous magnesium sulfate, then concentrated under reduced pressure and purified by silica gel column chromatography (hexane:ethyl acetate=1:1) to obtain the subject material. Amount obtained 81 mg (yield 56%). 
     Synthetic Example 6 
     N′-(aryloxy)-N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetimidamide (Compound 1-507) 
     
       
         
         
             
             
         
       
     
     30 mg (0.09 mmol) of the N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroethanethioamide synthesized by the method in Synthetic Example 4 was dissolved in 5 ml of ethanol, 50 mg (0.45 mmol) of O-ally hydroxylamine hydrochloride, 62 μl (0.45 mmol, 45 mg) of triethylamine and 25 mg (0.09 mmol) of silver carbonate were added thereto, and the resulting mixture was stirred at 50° C. for 5 hours and 20 minutes. After the reaction was completed, the reaction solution was returned to room temperature to filter off insoluble materials. The filtrate was concentrated under reduced pressure to perform liquid separation with ethyl acetate and 1% hydrochloric acid, and then the ethyl acetate layer was washed with a saturated saline solution, dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The ethyl acetate layer was purified by a TLC plate (one sheet of 0.5 mm plate, evolved with hexane:ethyl acetate=1:1) to obtain the subject material. Amount obtained mg (yield 45%). 
     Synthetic Example 7 
     N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2 (1H)-ylidene]-2,2,2-trifluoro-N′-hydroxyacetimidamide (Compound 1-499) 
     
       
         
         
             
             
         
       
     
     25 ml of ethanol was added to 1.00 g (3.00 mmol) of the N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroethanethioamide (1-20) synthesized by the method in Synthetic Example 4, 1.04 g (15.0 mmol) of hydroxylamine hydrochloride and 2.00 ml (1.50 g, 15.0 mmol) of triethylamine were added thereto in sequence, and the resulting mixture was stirred at 50° C. for 21 hours and 30 minutes. After the reaction was completed, ethyl acetate and 1% hydrochloric acid were added to the reaction solution to perform liquid separation, and the organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The organic layer was purified by silica gel column chromatography (hexane:ethyl acetate=1:1) to obtain the subject material. Amount obtained 625 mg (yield 63%) 
     Synthetic Example 8 
     N-(benzoyloxy)-N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2 (1H)-ylidene]-2,2,2-trifluoroacetimidamide (Compound 1-519) 
     
       
         
         
             
             
         
       
     
     30 mg (0.09 mmol) of the N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoro-N′-hydroxyacetamide (1-499) synthesized by the method in Synthetic Example 7 was dissolved in 3 ml of anhydrous acetonitrile, 24 μl (17 mg, 0.17 mmol) of triethylamine and 20 μg (22 mg, 0.17 mmol) of benzoyl chloride were added thereto in sequence, and the resulting mixture was stirred at room temperature for 10 minutes. After the reaction was completed, ethyl acetate and 1% hydrochloric acid were added to the reaction solution to perform liquid separation, and the organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The organic layer was purified by a TLC plate (one sheet of 0.5 mm plate, evolved with hexane:ethyl acetate=1:1) to obtain the subject material. Amount obtained 26 mg (yield 67%). 
     Synthetic Example 9 
     N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoro-N′-((propylcarbamoyl)oxy)acetimidamide (Compound 1-534) 
     
       
         
         
             
             
         
       
     
     5 ml of anhydrous acetonitrile was added to 11 mg (0.13 mmol) of normal propyl isocyanate, 40 mg (0.12 mmol) of the N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoro-N′-hydroxyacetamide (1-499) synthesized by the method in Synthetic Example 7 and 4 mg (0.04 mmol) of potassium-t-butoxide were added thereto, and the resulting mixture was stirred at room temperature for 1 hour. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and ethyl acetate and a saturated saline solution were added thereto to perform liquid separation. The ethyl acetate layer was dried over anhydrous magnesium sulfate, concentrated under reduced pressure and purified by a TLC plate (one sheet of 0.5 mm plate, evolved with hexane:ethyl acetate=1:3) to obtain the subject material. Amount obtained 16 mg (yield 32%) 
     Synthetic Example 10 
     Diisopropyl 1-((6-chloropyridin-3-yl)methyl)pyridyn-2(1H)-ylidenphospholamide trithioate (Compound 1-702) 
     
       
         
         
             
             
         
       
     
     4.0g (15.7 mmol) of 1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-imine hydrochloride obtained by the above-described method was suspended in 24.6 ml of dichloromethane, and under ice-cooling 1.35 ml of phosphorus trichloride over 10 mins, following 3.16g(31.2 mmol) of triethylamine dissolved in 37 ml of dichloromethane was added thereto. After the mixture was stirred for 2 hours at room temperature, 499 mg(15.6 mmol) of sulfur was added to the mixture, and the mixture was stirred over night at room temperature. Under ice-cooling 3.16g(31.2 mmol) of triethylamine, following 2.38g(31.2 mmol) of 2-propanethiol dissolved in 10 ml of dichloromethane were added to the mixture, additionally the mixture was stirred for a day. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and was extracted by 100 ml of diethylether twice. The ether solution was concentrated under reduced pressure, and 2.49g of crude compounds was obtained. 186 mg of crude compound was purified by a TLC plate (5 sheets of 0.5 mm plate, evolved with ethyl acetate) to obtain the subject material(47 mg. yield 9%) and (1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene)phosphoramidothioic dichloride (19 mg. yield 5%). 
     
       
         
         
             
             
         
       
     
     (1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene)phosphoramidothioic dichloride 
     Synthetic Example 11 
     N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-1,1,1-trifluoromethanesulfinamide (Compound 1-703) 
     
       
         
         
             
             
         
       
     
     330 mg(2 mmol) of sodium trifluoromethanesulfonate was added by 2 ml of ethylacetate and 154 mg(1 mmol) of phosphorus oxychloride and stirred for 5 min at room temperature. And 220 mg (0.86 mmol) of 1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-imine hydrochloride obtained by the above-described method was added to the mixture, and stirred for 2 hours. After the reaction was completed, the reaction mixture was purified by silica-gel column chromatography(eluent ethylacetate:hexane=1:1) to obtain the subject material (115 mg. yield 39%) 
     The preparation conditions of the compounds obtained in Synthetic Examples 1 to 11 and the compounds obtained in the same manner are shown in Tables 41 to 47 and the spectrum data are shown in the following Tables 48 to 53. 
     Further, the synthetic methods in the Table are described as follows. 
     A: the same method as in Synthetic Example 1 
     B: the same method as in Synthetic Example 2 
     C: the same method as in Synthetic Example 3 
     D: the same method as in Synthetic Example 4 
     E: the same method as in Synthetic Example 5 
     F: the same method as in Synthetic Example 6 
     G: the same method as in Synthetic Examples 7 and 8 
     H: the same method as in Synthetic Example 9 
     
       
         
           
               
               
               
               
               
               
               
               
             
               
                 TABLE 41 
               
               
                   
               
               
                   
                   
                   
                   
                   
                 Reaction 
                   
                   
               
               
                 Compound 
                   
                   
                 Base and 
                   
                 temperature, 
                 Synthetic 
                 Yield 
               
               
                 No. 
                 Raw material 1 
                 Raw material 2 
                 the like 
                 Solvent 
                 Time 
                 Method 
                 (%) 
               
               
                   
               
             
            
               
                 266-2 
                 69 mg (0.43 mmol) of 
                 84 mg (0.43 mmol) 
                 71 mg (0.52 
                 Acetonitrile 
                 reflux, 
                 A 
                 32 
               
               
                   
                 2-chloro-5- 
                 of 2,2,2-trifluoro- 
                 mmol) of 
                   
                 20 h 
               
               
                   
                 (chloromethyl)pyridine 
                 N-(1,3,4-thiadiazol- 
                 potassium 
               
               
                   
                   
                 2(3H)- 
                 carbonate 
               
               
                   
                   
                 ylidene))acetamide 
               
               
                 444-2 
                 56 mg (0.41 mmol) of 
                 66 mg (0.34 mmol) 
                 56 mg (0.41 
                 Acetonitrile 
                 reflux, 
                 A 
                 21 
               
               
                   
                 2-chloro-5- 
                 of 2,2,2-trifluoro- 
                 mmol) of 
                   
                 20 h 
               
               
                   
                 (chloromethyl)thiazole 
                 N-(1,3,4-thiadiazol- 
                 potassium 
               
               
                   
                   
                 2(3H)- 
                 carbonate 
               
               
                   
                   
                 ylidene))acetamide 
               
               
                 190-2 
                 71 mg (0.27 mmol) of 
                 53 μl (0.38 mmol) 
                 53 μl (0.38 
                 Dichloromethane 
                 Room 
                 B 
                 28 
               
               
                   
                 1-((6-chloropyridin-3- 
                 of anhydrous 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 yl)methyl)pyrimidin- 
                 trifluoroacetic 
                 triethylamine 
                   
                 1 h 
               
               
                   
                 2(1H)-imine 
                 acid 
               
               
                   
                 hydrochloride 
               
               
                 201-2 
                 120 mg (0.47 mmol) of 
                 99 μl (0.71 mmol) 
                 160 μl (1.17 
                 Dichloromethane 
                 Room 
                 B 
                 11 
               
               
                   
                 1-((6-chloropyridin- 
                 of anhydrous 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 3-yl)methyl)pyrazin- 
                 trifluoroacetic 
                 triethylamine 
                   
                 30 min 
               
               
                   
                 2(1H)-imine 
                 acid 
               
               
                   
                 hydrochloride 
               
               
                 223-2 
                 530 mg (2.07 mmol) of 
                 390 μl (2.79 mmol) 
                 537 μl (2.79 
                 Dichloromethane 
                 Room 
                 B 
                 14 
               
               
                   
                 2-chloro-2-((6- 
                 of anhydrous 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 chloropyridin-3- 
                 trifluoroacetic 
                 triethylamine 
                   
                 2 h 
               
               
                   
                 yl)methyl)pyridazin- 
                 acid 
               
               
                   
                 3(2H)-imine hydrochloride 
               
               
                 146-2 
                 113 mg (0.70 mmol) of 
                 145 mg (0.70 mmol) 
                 116 mg (0.84 
                 Acetonitrile 
                 reflux, 
                 A 
                 15 
               
               
                   
                 2-chloro-5- 
                 of 2,2,2-trifluoro- 
                 mmol) of 
                   
                 13 h 
               
               
                   
                 (chloromethyl)pyridine 
                 N-(3-hydroxypyridin- 
                 potassium 
               
               
                   
                   
                 2(1H)- 
                 carbonate 
               
               
                   
                   
                 ylidene))acetamide 
               
               
                 224-2 
                 190 mg (0.73 mmol) of 
                 168 μl (1.20 mmol) 
                 220 μl (1.60 
                 Dichloromethane 
                 Room 
                 B 
                 16 
               
               
                   
                 2-((2-chlorothiazol-5- 
                 of anhydrous 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 yl)methyl)pyridazin- 
                 trifluoroacetic acid 
                 triethylamine 
                   
                 5 min 
               
               
                   
                 3(2H)-imine hydrochloride 
               
               
                 102-2 
                 116 mg (0.72 mmol) of 
                 155 mg (0.72 mmol) 
                 109 mg (0.79 
                 Acetonitrile 
                 reflux, 
                 A 
                 22 
               
               
                   
                 2-chloro-5- 
                 of N-(3-cyanopyridin- 
                 mmol) of 
                   
                 8 h 
               
               
                   
                 (chloromethyl)pyridine 
                 2(1H)-ylidene))2,2,2- 
                 potassium 
               
               
                   
                   
                 trifluoroacetamide 
                 carbonate 
               
               
                 212-2 
                 59 mg (0.37 mmol) of 
                 70 mg (0.37 mmol) 
                 55 mg (0.40 
                 Acetonitrile 
                 reflux, 
                 A 
                 32 
               
               
                   
                 2-chloro-5- 
                 of 2,2,2-trifluoro- 
                 mmol) of 
                   
                 7 h 
               
               
                   
                 (chloromethyl)pyridine 
                 N-(pyrimidin-4(3H)- 
                 potassium 
               
               
                   
                   
                 ylidene))acetamide 
                 carbonate 
               
               
                 1-20 
                 20.0 g (63.4 mmol) of 
                 16.3 g (36.7 mmol) 
                 6.72 mg (63.4 
                 Toluene 
                 50° C., 
                 D 
                 94 
               
               
                   
                 N-[1-((6-chloropyridin-3- 
                 of phosphorus 
                 mmol) of 
                   
                 19 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 pentasulfide 
                 sodium 
               
               
                   
                 ylidene]-2,2,2- 
                   
                 carbonate 
               
               
                   
                 trifluoroacetamide 
               
               
                 12-2 
                 78 mg (0.38 mmol) of 
                 73 mg (0.38 mmol) 
                 58 mg (0.42 
                 Acetonitrile 
                 reflux, 
                 A 
                 44 
               
               
                   
                 2-chloro-4- 
                 of 2,2,2-trifluoro- 
                 mmol) of 
                   
                 3.5 h 
               
               
                   
                 (bromomethyl)pyridine 
                 N-(pyridin-2(1H)- 
                 potassium 
               
               
                   
                   
                 ylidene))acetamide 
                 carbonate 
               
               
                 213-2 
                 79 mg (0.47 mmol) of 
                 90 mg (0.47 mmol) 
                 72 mg (0.52 
                 Acetonitrile 
                 reflux, 
                 A 
                 42 
               
               
                   
                 2-chloro-5- 
                 of 2,2,2-trifluoro- 
                 mmol) of 
                   
                 12 h 
               
               
                   
                 (chloromethyl)thiazole 
                 N-(pyrimidin-4(3H)- 
                 potassium 
               
               
                   
                   
                 ylidene))acetamide 
                 carbonate 
               
               
                 1-17 
                 150 mg (0.66 mmol) of 
                 177 mg (0.66 mmol) 
                 200 mg (1.46 
                 Acetonitrile 
                 50° C., 
                 C 
                 21 
               
               
                   
                 1-[(6-chloropyridin-3- 
                 of 4-nitrophenyl(2,2,2- 
                 mmol) of 
                   
                 2 h 
               
               
                   
                 yl)methyl]pyridin-2(1H)- 
                 trifluoroethyl)carbamate 
                 potassium 
               
               
                   
                 imine hydrochloride 
                   
                 carbonate 
               
               
                 1-18 
                 150 mg (0.66 mmol) of 
                 184 mg (0.66 mmol) 
                 200 mg (1.46 
                 Acetonitrile 
                 50° C., 
                 C 
                 30 
               
               
                   
                 1-[(6-chloropyridin-3- 
                 of 4-nitrophenyl(1,1,1- 
                 mmol) of 
                   
                 2 h 
               
               
                   
                 yl)methyl]pyridin-2(1H)- 
                 trifluoropropan-2- 
                 potassium 
               
               
                   
                 imine hydrochloride 
                 yl)carbamate 
                 carbonate 
               
               
                 1-19 
                 150 mg (0.66 mmol) of 
                 220 mg (0.66 mmol) 
                 200 mg (1.46 
                 Acetonitrile 
                 50° C., 
                 C 
                 27 
               
               
                   
                 1-[(6-chloropyridin-3- 
                 of 1,1,1,3,3,3- 
                 mmol) of 
                   
                 3 h 
               
               
                   
                 yl)methyl]pyridin- 
                 hexafluoropropan- 
                 potassium 
               
               
                   
                 2(1H)-imine 
                 2-yl(4- 
                 carbonate 
               
               
                   
                 hydrochloride 
                 nitrophenyl)carbamate 
               
               
                 7-2 
                 116 mg (0.72 mmol) of 
                 137 mg (0.72 mmol) 
                 110 mg (0.80 
                 Acetonitrile 
                 reflux, 
                 A 
                 49 
               
               
                   
                 2-chloro-5- 
                 of 2,2,2-trifluoro- 
                 mmol) of 
                   
                 5 h 
               
               
                   
                 (chloromethyl)pyrazine 
                 N-(pyridin-2(1H)- 
                 potassium 
               
               
                   
                   
                 ylidene))acetamide 
                 carbonate 
               
               
                 1-13 
                 200 mg (0.78 mmol) of 
                 103 μl (1.17 mmol) 
                 EDC- 
                 Dichloromethane 
                 Room 
                 B 
                 21 
               
               
                   
                 1-[(6-chloropyridin-3- 
                 of 2,2,2- 
                 HCl225 mg 
                   
                 temperature, 
               
               
                   
                 yl)methyl]pyridin- 
                 trifluoropropionic 
                 (1.17 mmol), 
                   
                 12 h 
               
               
                   
                 2(1H)-imine 
                 acid 
                 DMAP238 mg(1.95 
               
               
                   
                 hydrochloride 
                   
                 mmol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
             
               
                 TABLE 42 
               
               
                   
               
               
                   
                   
                   
                   
                   
                 Reaction 
                   
                   
               
               
                 Compound 
                   
                   
                 Base and 
                   
                 temperature, 
                 Synthetic 
                 Yield 
               
               
                 No. 
                 Raw material 1 
                 Raw material 2 
                 the like 
                 Solvent 
                 Time 
                 Method 
                 (%) 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 168-2 
                 273 mg (1.70 mmol) of 
                 350 g (1.70 mmol) 
                 248 mg (1.80 
                 DMF 
                 65° C., 
                 A 
                 15 
               
               
                   
                 2-chloro-5- 
                 of 2,2,2-trifluoro- 
                 mmol) of 
                   
                 2 h 
               
               
                   
                 (chloromethyl)pyridine 
                 N-(5-hydroxypyridin- 
                 potassium 
               
               
                   
                   
                 2(1H)- 
                 carbonate 
               
               
                   
                   
                 ylidene))acetamide 
               
               
                 1-21 
                 23 mg (0.077 mmol) of 
                 41 mg (0.092 mmol) 
                 10 mg (0.092 
                 THF 
                 Room 
                 D 
                 49 
               
               
                   
                 N-[1-((6-chloropyridin-3- 
                 of phosphorus 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 pentasulfide 
                 sodium 
                   
                 2 h 
               
               
                   
                 ylidene]-2,2- 
                   
                 carbonate 
               
               
                   
                 difluoroacetamide 
               
               
                 3-20 
                 30 mg (0.10 mmol) of 
                 49 mg (0.11 mmol) 
                 12 mg (0.11 
                 THF 
                 Room 
                 D 
                 49 
               
               
                   
                 N-[1-((6-fluoropyridin-3- 
                 of phosphorus 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 pentasulfide 
                 sodium 
                   
                 3 h 
               
               
                   
                 ylidene]-2,2,2- 
                   
                 carbonate 
               
               
                   
                 trifluoroacetamide 
               
               
                 4-20 
                 30 mg (0.083 mmol) of 
                 41 mg (0.09 mmol) 
                 10 mg (0.09 
                 THF 
                 Room 
                 D 
                 61 
               
               
                   
                 N-[1-((6-bromopyridin-3- 
                 of phosphorus 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 pentasulfide 
                 sodium 
                   
                 3 h 
               
               
                   
                 ylidene]-2,2,2- 
                   
                 carbonate 
               
               
                   
                 trifluoroacetamide 
               
               
                 3-3 
                 116 mg (0.72 mmol) of 
                 116 mg (0.68 mmol) 
                 110 mg (0.80 
                 Acetonitrile 
                 reflux, 
                 A 
                 27 
               
               
                   
                 2-fluoro-5- 
                 of 2,2-difluoro-N- 
                 mmol) of 
                   
                 6 h 
               
               
                   
                 (bromomethyl)pyridine 
                 (pyridin-2(1H)- 
                 potassium 
               
               
                   
                   
                 ylidene))acetamide 
                 carbonate 
               
               
                 4-3 
                 50 mg (0.20 mmol) of 
                 35 mg (0.20 mmol) 
                 33 mg (0.24 
                 Acetonitrile 
                 reflux, 
                 A 
                 53 
               
               
                   
                 2-bromo-5- 
                 of 2,2-difluoro-N- 
                 mmol) of 
                   
                 6 h 
               
               
                   
                 (bromomethyl)pyridine 
                 (pyridin-2(1H)- 
                 potassium 
               
               
                   
                   
                 ylidene))acetamide 
                 carbonate 
               
               
                 5-5 
                 46 mg (0.21 mmol) of 
                 50 mg (0.21 mmol) 
                 35 mg (0.25 
                 Acetonitrile 
                 reflux, 
                 A 
                 26 
               
               
                   
                 5-(bromomethyl)-2-chloro- 
                 of 2,2,3,3,3- 
                 mmol) of 
                   
                 2 h 
               
               
                   
                 3-fluoropyridine 
                 pentafluoro-N- 
                 potassium 
               
               
                   
                   
                 (pyridin-2(1H)- 
                 carbonate 
               
               
                   
                   
                 ylidene))propanamide 
               
               
                 6-5 
                 43 mg (0.21 mmol) of 
                 50 mg (0.21 mmol) 
                 35 mg (0.25 
                 Acetonitrile 
                 reflux, 
                 A 
                 21 
               
               
                   
                 5-(bromomethyl)-2- 
                 of 2,2,3,3,3- 
                 mmol) of 
                   
                 2 h 
               
               
                   
                 chloropyrimidine 
                 pentafluoro-N- 
                 potassium 
               
               
                   
                   
                 (pyridin-2(1H)- 
                 carbonate 
               
               
                   
                   
                 ylidene))propanamide 
               
               
                 1-22 
                 37 mg (0.11 mmol) of 
                 49 mg (0.11 mmol) 
                 12 mg (0.11 
                 THF 
                 Room 
                 D 
                 31 
               
               
                   
                 2-chloro-N-[1-((6- 
                 of phosphorus 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 chloropyridin-3- 
                 pentasulfide 
                 sodium 
                   
                 4 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                   
                 carbonate 
               
               
                   
                 ylidene]-2,2- 
               
               
                   
                 difluoroacetamide 
               
               
                 1-23 
                 31 mg (0.085 mmol) of 
                 38 mg (0.085 mmol) 
                 9 mg (0.0854 
                 THF 
                 Room 
                 D 
                 59 
               
               
                   
                 N-[1-((6-chloropyridin-3- 
                 of phosphorus 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 pentasulfide 
                 sodium 
                   
                 4 h 
               
               
                   
                 ylidene]-2,2,3,3,3- 
                   
                 carbonate 
               
               
                   
                 pentafluoropropanamide 
               
               
                 5-20 
                 36 mg (0.11 mmol) of 
                 49 mg (0.11 mmol) 
                 12 mg (0.11 
                 THF 
                 Room 
                 D 
                 100 
               
               
                   
                 N-[1-((6-chloro-5- 
                 of phosphorus 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 fluoropyridin-3- 
                 pentasulfide 
                 sodium 
                   
                 4 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                   
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroacetamide 
               
               
                 5-3 
                 65 mg (0.29 mmol) of 
                 50 mg (0.29 mmol) 
                 48 mg (0.35 
                 Acetonitrile 
                 reflux, 
                 A 
                 38 
               
               
                   
                 5-(bromomethyl)-2-chloro- 
                 of 2,2-difluoro-N- 
                 mmol) of 
                   
                 3 h 
               
               
                   
                 3-fluoropyridine 
                 (pyridin-2(1H)- 
                 potassium 
               
               
                   
                   
                 ylidene))acetamide 
                 carbonate 
               
               
                 6-3 
                 60 mg (0.29 mmol) of 5- 
                 50 mg (0.29 mmol) 
                 48 mg (0.35 
                 Acetonitrile 
                 reflux, 
                 A 
                 37 
               
               
                   
                 (bromomethyl)-2- 
                 of 2,2-difluoro-N- 
                 mmol) of 
                   
                 3 h 
               
               
                   
                 chloropyrimidine 
                 (pyridin-2(1H)- 
                 potassium 
               
               
                   
                   
                 ylidene))acetamide 
                 carbonate 
               
               
                 8-2 
                 73 mg (0.45 mmol) of 
                 97 mg (0.51 mmol) 
                 83 mg (0.60 
                 DMF 
                 65° C., 
                 A 
                 32 
               
               
                   
                 3-chloro-6- 
                 of 2,2,2-trifluoro- 
                 mmol) of 
                   
                 3 h 
               
               
                   
                 (chloromethyl)pyridazine 
                 N-(pyridin-2(1H)- 
                 potassium 
               
               
                   
                   
                 ylidene))acetamide 
                 carbonate 
               
               
                 5-4 
                 54 mg (0.24 mmol) of 
                 50 mg (0.24 mmol) 
                 41 mg (0.30 
                 Acetonitrile 
                 reflux, 
                 A 
                 51 
               
               
                   
                 5-(bromomethyl)-2-chloro- 
                 of 2-chloro-2,2- 
                 mmol) of 
                   
                 6 h 
               
               
                   
                 3-fluoropyridine 
                 difluoro-N-(pyridin- 
                 potassium 
               
               
                   
                   
                 2(1H)- 
                 carbonate 
               
               
                   
                   
                 ylidene))acetamide 
               
               
                 4-4 
                 60 mg (0.24 mmol) of 
                 50 mg (0.24 mmol) 
                 41 mg (0.30 
                 Acetonitrile 
                 reflux, 
                 A 
                 48 
               
               
                   
                 2-bromo-5- 
                 of 2-chloro-2,2- 
                 mmol) of 
                   
                 6 h 
               
               
                   
                 bromomethylpyridine 
                 difluoro-N-(pyridin- 
                 potassium 
               
               
                   
                   
                 2(1H)- 
                 carbonate 
               
               
                   
                   
                 ylidene))acetamide 
               
               
                 6-4 
                 49 mg (0.24 mmol) of 
                 50 mg (0.24 mmol) 
                 41 mg (0.30 
                 Acetonitrile 
                 reflux, 
                 A 
                 55 
               
               
                   
                 5-(bromomethyl)-2- 
                 of 2-chloro-2,2- 
                 mmol) of 
                   
                 6 h 
               
               
                   
                 chloropyrimidine 
                 difluoro-N-(pyridin- 
                 potassium 
               
               
                   
                   
                 2(1H)- 
                 carbonate 
               
               
                   
                   
                 ylidene))acetamide 
               
               
                 4-5 
                 65 mg (0.26 mmol) of 
                 50 mg (0.26 mmol) 
                 41 mg (0.30 
                 Acetonitrile 
                 reflux, 
                 A 
                 8 
               
               
                   
                 2-bromo-5- 
                 of 2,2,3,3,3- 
                 mmol) of 
                   
                 2 h 
               
               
                   
                 bromomethylpyridine 
                 pentafluoro-N- 
                 potassium 
               
               
                   
                   
                 (pyridin-2(1H)- 
                 carbonate 
               
               
                   
                   
                 ylidene))propanamide 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
             
               
                 TABLE 43 
               
               
                   
               
               
                   
                   
                   
                   
                   
                 Reaction 
                   
                   
               
               
                 Compound 
                   
                   
                 Base and 
                   
                 temperature, 
                 Synthetic 
                 Yield 
               
               
                 No. 
                 Raw material 1 
                 Raw material 2 
                 the like 
                 Solvent 
                 Time 
                 Method 
                 (%) 
               
               
                   
               
             
            
               
                 2-20 
                 70 mg (0.22 mmol) of N- 
                 107 mg (0.24 mmol) 
                 25 mg (0.24 
                 THF 
                 Room 
                 D 
                 11 
               
               
                   
                 [1-((2-chlorothiazol-5- 
                 of phosphorus 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 yl)methyl)pyridin- 
                 pentasulfide 
                 sodium 
                   
                 4 h 
               
               
                   
                 2(1H)-ylidene]-2,2,2- 
                   
                 carbonate 
               
               
                   
                 trifluoroacetamide 
               
               
                 10-20 
                 130 mg (0.37 mmol) of 
                 181 mg (0.41 mmol) 
                 43 mg (0.41 
                 THF 
                 Room 
                 D 
                 93 
               
               
                   
                 2,2,2-trifluoro-N-[1- 
                 of phosphorus 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 ((6-trifluoromethyl)pyridin- 
                 pentasulfide 
                 sodium 
                   
                 4 h 
               
               
                   
                 3-yl)methyl)pyridin- 
                   
                 carbonate 
               
               
                   
                 2(1H)-ylidene]- 
               
               
                   
                 acetamide 
               
               
                 3-4 
                 110 mg (0.58 mmol) of 
                 105 mg (0.51 mmol) 
                 103 mg (0.75 
                 DMF 
                 65° C., 
                 A 
                 63 
               
               
                   
                 2-fluoro-5- 
                 of 2-chloro-2,2- 
                 mmol) of 
                   
                 2 h 
               
               
                   
                 (bromomethyl)pyridine 
                 difluoro-N- 
                 potassium 
               
               
                   
                   
                 (pyridin-2(1H)- 
                 carbonate 
               
               
                   
                   
                 ylidene))acetamide 
               
               
                 3-5 
                 110 mg (0.58 mmol) of 
                 139 mg (0.58 mmol) 
                 88 mg (0.63 
                 DMF 
                 65° C., 
                 A 
                 22 
               
               
                   
                 2-fluoro-5- 
                 of 2,2,3,3,3- 
                 mmol) of 
                   
                 2 h 
               
               
                   
                 (bromomethyl)pyridine 
                 pentafluoro-N- 
                 potassium 
               
               
                   
                   
                 (pyridin-2(1H)- 
                 carbonate 
               
               
                   
                   
                 ylidene)propanamide 
               
               
                 11-20 
                 40 mg (0.15 mmol) of 
                 65 mg (0.11 mmol) 
                 16 mg (0.15 
                 THF 
                 Room 
                 D 
                 53 
               
               
                   
                 2,2,2-trifluoro-N-[1- 
                 of phosphorus 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 ((tetrahydrofuran-3- 
                 pentasulfide 
                 sodium 
                   
                 4 h 
               
               
                   
                 yl)methyl)pyridin- 
                   
                 carbonate 
               
               
                   
                 2(1H)-ylidene]acetamide 
               
               
                 1-14 
                 200 mg (0.78 mmol) of 
                 76 μl (0. 94 mmol) 
                 32 μl (0.23 
                 Acetonitrile 
                 reflux, 
                 B 
                 28 
               
               
                   
                 1-[(6-chloropyridin-3- 
                 of acrylic acid 
                 mmol) of 
                   
                 1 h 
               
               
                   
                 yl)methyl]pyridin- 
                 chloride 
                 triethylamine 
               
               
                   
                 2(1H)-imine 
               
               
                   
                 hydrochloride 
               
               
                 1-37 
                 78 mg (0.28 mmol) of N- 
                 125 mg (0.28 mmol) 
                 30 mg (0.28 
                 THF 
                 Room 
                 D 
                 21 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of phosphorus 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 yl)methyl)pyridin- 
                 pentasulfide 
                 sodium 
                   
                 2 h 
               
               
                   
                 2(1H)-ylidene]- 
                   
                 carbonate 
               
               
                   
                 propionamide 
               
               
                 1-39 
                 180 mg (0.96 mmol) of N- 
                 341 mg (0.75 mmol) 
                 102 mg (0.96 
                 THF 
                 Room 
                 D 
                 29 
               
               
                   
                 [1-((6-chloropyridin- 
                 of phosphorus 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 3-yl)methyl)pyridin- 
                 pentasulfide 
                 sodium 
                   
                 2 h 
               
               
                   
                 2(1H)-ylidene]- 
                   
                 carbonate 
               
               
                   
                 isobutyramide 
               
               
                 1-40 
                 54 mg (0.19 mmol) of N- 
                 54 mg (0.19 mmol) 
                 20 mg (0.19 
                 THF 
                 Room 
                 D 
                 12 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of phosphorus 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 yl)methyl)pyridin- 
                 pentasulfide 
                 sodium 
                   
                 2 h 
               
               
                   
                 2(1H)-ylidene]- 
                   
                 carbonate 
               
               
                   
                 cyclopropane 
               
               
                   
                 carboxyamide 
               
               
                 1-15 
                 200 mg (0.78 mmol) of 
                 83 mg (0.94 mmol) 
                 320 μl (2.34 
                 Acetonitrile 
                 reflux, 
                 B 
                 19 
               
               
                   
                 1-[(6-chloropyridin-3- 
                 of propyol 
                 mmol) of 
                   
                 5 h 
               
               
                   
                 yl)methyl]pyridin-2(1H)- 
                 oxychloride 
                 triethylamine 
               
               
                   
                 imine hydrochloride 
               
               
                 1-35 
                 26 mg (0.074 mmol) of N- 
                 26 mg (0.06 mmol) 
                 8 mg (0.074 
                 THF 
                 Room 
                 D 
                 23 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of phosphorus 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 pentasulfide 
                 sodium 
                   
                 1.5 h 
               
               
                   
                 ylidene]-3- 
                   
                 carbonate 
               
               
                   
                 phyenylpropanamide 
               
               
                 1-501 
                 100 mg (0.30 mmol) of N- 
                 145 mg (1.50 mmol) 
                 205 μl (1.50 
                 Ethanol 
                 50° C., 
                 F 
                 14 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of O-ethyl 
                 mmol) of 
                   
                 19.5 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 hydroxylamine 
                 triethylamine 
               
               
                   
                 ylidene]-2,2,2- 
                 hydrochloride 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-499 
                 1.00 g (3.00 mmol) of N- 
                 1.04 g (15.0 mmol) 
                 2.00 ml (15.0 
                 Ethanol 
                 50° C., 
                 F 
                 63 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of hydroxylamine 
                 mmol) of 
                   
                 21 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 hydrochloride 
                 triethylamine 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-510 
                 100 mg (0.30 mmol) of N- 
                 239 mg (1.50 mmol) 
                 205 μl (1.50 
                 Ethanol 
                 50° C., 
                 F 
                 20 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of O-benzyl 
                 mmol) of 
                   
                 19.5 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 hydroxylamine 
                 triethylamine 
               
               
                   
                 ylidene]-2,2,2- 
                 hydrochloride 
               
               
                   
                 trifluoroethanethioamideL 
               
               
                 1-511 
                 30 mg (0.09 mmol) of N- 
                 20 μl (0.28 mmol) 
                 38 μl (0.28 
                 Acetonitrile 
                 Room 
                 G 
                 72 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of acetyl chloride 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 yl)methyl)pyridin- 
                   
                 triethylamine 
                   
                 15 min 
               
               
                   
                 2(1H)-ylidene]-2,2,2- 
               
               
                   
                 trifluoro-N′- 
               
               
                   
                 hydroxyacetimidamide 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
             
               
                 TABLE 44 
               
               
                   
               
               
                   
                   
                   
                   
                   
                 Reaction 
                   
                   
               
               
                 Compound 
                   
                   
                 Base and 
                   
                 temperature, 
                 Synthetic 
                 Yield 
               
               
                 No. 
                 Raw material 1 
                 Raw material 2 
                 the like 
                 Solvent 
                 Time 
                 Method 
                 (%) 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 1-519 
                 30 mg (0.09 mmol) of 
                 20 μl (0.17 mmol) 
                 24 μl (0.17 
                 Acetonitrile 
                 Room 
                 G 
                 67 
               
               
                   
                 N-[1-((6- 
                 of benzoyl 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 chloropyridin-3- 
                 chloride 
                 triethylamine 
                   
                 10 min 
               
               
                   
                 yl)methyl)pyridin- 
               
               
                   
                 2(1H)-ylidene]-2,2,2- 
               
               
                   
                 trifluoro-N′- 
               
               
                   
                 hydroxyacetimidamide 
               
               
                 1-523 
                 30 mg (0.09 mmol) of 
                 20 μl (0.26 mmol) 
                 36 μl (0.26 
                 Acetonitrile 
                 Room 
                 G 
                 49 
               
               
                   
                 N-[1-((6- 
                 of methyl 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 chloropyridin-3- 
                 chloroformate 
                 triethylamine 
                   
                 20 min 
               
               
                   
                 yl)methyl)pyridin- 
               
               
                   
                 2(1H)-ylidene]-2,2,2- 
               
               
                   
                 trifluoro-N′- 
               
               
                   
                 hydroxyacetimidamide 
               
               
                 1-528 
                 30 mg (0.09 mmol) of 
                 20 μl (0.18 mmol) 
                 25 μl (0.18 
                 Acetonitrile 
                 Room 
                 G 
                 100 
               
               
                   
                 N-[1-((6- 
                 of methanesulfonyl 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 chloropyridin-3- 
                 chloride 
                 triethylamine 
                   
                 20 min 
               
               
                   
                 yl)methyl)pyridin- 
               
               
                   
                 2(1H)-ylidene]-2,2,2- 
               
               
                   
                 trifluoro-N′- 
               
               
                   
                 hydroxyacetimidamide 
               
               
                 1-531 
                 30 mg (0.09 mmol) of 
                 28 ml (0.15 mmol) 
                 21 μl (0.15 
                 Acetonitrile 
                 Room 
                 G 
                 100 
               
               
                   
                 N-[1-((6- 
                 of 4- 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 chloropyridin-3- 
                 methylbenzenesufonyl 
                 triethylamine 
                   
                 12 h 
               
               
                   
                 yl)methyl)pyridin- 
                 chloride 
               
               
                   
                 2(1H)-ylidene]- 
               
               
                   
                 2,2,2-trifluoro-N′- 
               
               
                   
                 hydroxyacetimidamide 
               
               
                 1-507 
                 30 mg (0.09 mmol) of 
                 50 mg (0.45 mmol) 
                 62 μl (0.45 
                 Ethanol 
                 50° C., 
                 F 
                 45 
               
               
                   
                 N-[1-((6- 
                 of O-allyl 
                 mmol) of 
                   
                 5 h 
               
               
                   
                 chloropyridin-3- 
                 hydroxylamine 
                 triethylamine, 
               
               
                   
                 yl)methyl)pyridin- 
                 hydrochloride 
                 25 mg (0.09 
               
               
                   
                 2(1H)-ylidene]- 
                   
                 mmol) of silver 
               
               
                   
                 2,2,2- 
                   
                 carbonate 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-516 
                 30 mg (0.09 mmol) of 
                 20 μl (0.25 mmol) 
                 34 μl (0.25 
                 Acetonitrile 
                 Room 
                 G 
                 64 
               
               
                   
                 N-[1-((6- 
                 of acryloyl 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 chloropyridin-3- 
                 chloride 
                 triethylamine 
                   
                 20 min 
               
               
                   
                 yl)methyl)pyridin- 
               
               
                   
                 2(1H)-ylidene]- 
               
               
                   
                 2,2,2-trifluoro-N′- 
               
               
                   
                 hydroxyacetimidamide 
               
               
                 1-518 
                 30 mg (0.09 mmol) of 
                 15 mg (0.18 mmol) 
                 EDC- 
                 Dichloromethane 
                 Room 
                 G 
                 22 
               
               
                   
                 N-[1-((6- 
                 of 3-butynoate 
                 HCl35 mg(0.18 
                   
                 temperature, 
               
               
                   
                 chloropyridin-3- 
                   
                 mmol), 
                   
                 21 h 
               
               
                   
                 yl)methyl)pyridin- 
                   
                 DMAP22 mg(0.18 
               
               
                   
                 2(1H)-ylidene]- 
                   
                 mmol) 
               
               
                   
                 2,2,2-trifluoro-N′- 
               
               
                   
                 hydroxyacetimidamide 
               
               
                 1-527 
                 30 mg (0.09 mmol) of 
                 20 μl (0.16 mmol) 
                 22 μl (0.16 
                 Acetonitrile 
                 Room 
                 G 
                 54 
               
               
                   
                 N-[1-((6- 
                 of phenyl 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 chloropyridin-3- 
                 chloroformate 
                 triethylamine 
                   
                 1.5 h 
               
               
                   
                 yl)methyl)pyridin- 
               
               
                   
                 2(1H)-ylidene]- 
               
               
                   
                 2,2,2-trifluoro-N′- 
               
               
                   
                 hydroxyacetimidamide 
               
               
                 1-521 
                 30 mg (0.09 mmol) of 
                 20 mg (0.14 mmol) 
                 40 μl (0.28 
                 Acetonitrile 
                 Room 
                 G 
                 46 
               
               
                   
                 N-[1-((6- 
                 of nicotinic acid 
                 mmol) of 
                   
                 temperature, 
               
               
                   
                 chloropyridin-3- 
                 chloride 
                 triethylamine 
                   
                 1.5 h 
               
               
                   
                 yl)methyl)pyridin- 
                 hydrochloride 
               
               
                   
                 2(1H)-ylidene]- 
               
               
                   
                 2,2,2-trifluoro-N′- 
               
               
                   
                 hydroxyacetimidamide 
               
               
                 1-43 
                 100 mg (0.30 mmol) of 
                 Ethylamine (30% 
                 90 μl (0. 60 
                 Ethanol 
                 50° C., 
                 E 
                 57 
               
               
                   
                 N-[1-((6- 
                 methanol 
                 mmol) of 
                   
                 1.5 h 
               
               
                   
                 chloropyridin-3- 
                 solution, 0.60 
                 triethylamine, 
               
               
                   
                 yl)methyl)pyridin- 
                 mmol) 
                 91 mg (0.33 
               
               
                   
                 2(1H)-ylidene]- 
                   
                 mmol) of silver 
               
               
                   
                 2,2,2- 
                   
                 carbonate 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-536 
                 50 mg (0.15 mmol) of 
                 20 μl (0.17 mmol) 
                 TBuOK 
                 Acetonitrile 
                 Room 
                 H 
                 30 
               
               
                   
                 N-[1-((6- 
                 of benzyl 
                 5 mg (0.04 mmol) 
                   
                 temperature, 
               
               
                   
                 chloropyridin-3- 
                 isocyanate 
                   
                   
                 1 h 
               
               
                   
                 yl)methyl)pyridin- 
               
               
                   
                 2(1H)-ylidene]- 
               
               
                   
                 2,2,2-trifluoro-N′- 
               
               
                   
                 hydroxyacetimidamide 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
             
               
                 TABLE 45 
               
               
                   
               
               
                   
                   
                   
                   
                   
                 Reaction 
                   
                   
               
               
                 Compound 
                   
                   
                 Base and 
                   
                 temperature, 
                 Synthetic 
                 Yield 
               
               
                 No. 
                 Raw material 1 
                 Raw material 2 
                 the like 
                 Solvent 
                 Time 
                 Method 
                 (%) 
               
               
                   
               
             
            
               
                 1-42 
                 150 mg (0.45 mmol) of N- 
                 Methylamine 
                 124 mg (0.45 
                 Ethanol 
                 50° C., 
                 E 
                 56 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 (40% methanol 
                 mmol) of silver 
                   
                 1 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 solution, 
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
                 1.36 mmol) 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-500 
                 50 mg (0.15 mmol) of N- 
                 63 mg (0.75 mmol) 
                 103 μl (0.75 
                 Ethanol 
                 50° C., 
                 F 
                 50 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of O-methyl 
                 mmol) of 
                   
                 5 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 hydroxylamine 
                 triethylamine, 
               
               
                   
                 ylidene]-2,2,2- 
                 hydrochloride 
                 41 mg (0.15 
               
               
                   
                 trifluoroethanethioamide 
                   
                 mmol) of silver 
               
               
                   
                   
                   
                 carbonate 
               
               
                 1-504 
                 50 mg (0.15 mmol) of N- 
                 95 mg (0.75 mmol) 
                 165 μl (1.20 
                 Ethanol 
                 50° C., 
                 F 
                 19 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of O-t-butyl 
                 mmol) of 
                   
                 5 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 hydroxylamine 
                 triethylamine, 
               
               
                   
                 ylidene]-2,2,2- 
                 hydrochloride 
                 62 mg (0.23 
               
               
                   
                 trifluoroethanethioamide 
                   
                 mmol) of silver 
               
               
                   
                   
                   
                 carbonate 
               
               
                 1-534 
                 40 mg (0.12 mmol) of N- 
                 11 mg (0.13 mmol) 
                 137 mg (0.50 
                 Acetonitrile 
                 Room 
                 H 
                 32 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of n-propyl 
                 mmol) of silver 
                   
                 temperature, 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 isocyanate 
                 carbonate 
                   
                 1 h 
               
               
                   
                 ylidene]-2,2,2-trifluoro- 
               
               
                   
                 N′-hydroxyacetimidamide 
               
               
                 1-535 
                 40 mg (0.12 mmol) of N- 
                 14 mg (0.13 mmol) 
                 91 mg (0.33 
                 Acetonitrile 
                 Room 
                 H 
                 54 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of chloroethyl 
                 mmol) of silver 
                   
                 temperature, 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 isocyanate 
                 carbonate 
                   
                 1 h 
               
               
                   
                 ylidene]-2,2,2-trifluoro- 
               
               
                   
                 N′-hydroxyacetimidamide 
               
               
                 1-72 
                 150 mg (0.45 mmol) of N- 
                 74 μl (0.68 mmol) 
                 91 mg (0.33 
                 Ethanol 
                 50° C., 
                 E 
                 45 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of benzylamine 
                 mmol) of silver 
                   
                 3 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                   
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-150 
                 100 mg (0.30 mmol) of N- 
                 56 μl (0.60 mmol) 
                 30 μl (0.22 
                 Ethanol 
                 50° C., 
                 E 
                 50 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of 
                 mmol) of 
                   
                 5 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 methylthioethylamine 
                 triethylamine 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-67 
                 100 mg (0.30 mmol) of N- 
                 74 μl (1.20 mmol) 
                 91 mg (0.33 
                 Ethanol 
                 50° C., 
                 E 
                 49 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of 2- 
                 mmol) of silver 
                   
                 2 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 aminoethanol 
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-515 
                 30 mg (0.09 mmol) of N- 
                 40 μl (0.44 mmol) 
                 34 μl (0.25 
                 Acetonitrile 
                 50° C., 
                 G 
                 67 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of cyclopropane- 
                 mmol) of 
                   
                 2 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 carboxylic 
                 triethylamine 
               
               
                   
                 ylidene]-2,2,2-trifluoro- 
                 acid chloride 
               
               
                   
                 N′-hydroxyacetimidamide 
               
               
                 1-56 
                 100 mg (0.30 mmol) of N- 
                 38 μl (0.60 mmol) 
                 27 μl (0.20 
                 Ethanol 
                 50° C., 2 h→ 
                 E 
                 57 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of propargylamine 
                 mmol) of 
                   
                 reflux, 2 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                   
                 triethylamine 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-512 
                 30 mg (0.09 mmol) of N- 
                 20 μl (0.23 mmol) 
                 91 mg (0.33 
                 Acetonitrile 
                 Room 
                 G 
                 32 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of propionyl 
                 mmol) of silver 
                   
                 temperature, 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 chloride 
                 carbonate 
                   
                 30 min 
               
               
                   
                 ylidene]-2,2,2-trifluoro- 
               
               
                   
                 N′-hydroxyacetimidamide 
               
               
                 1-514 
                 30 mg (0.09 mmol) of N- 
                 20 μl (0.19 mmol) 
                 27 μl (0.20 
                 Acetonitrile 
                 Room 
                 G 
                 61 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of isopropionyl 
                 mmol) 
                   
                 temperature, 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 chloride 
                   
                   
                 2 h 
               
               
                   
                 ylidene]-2,2,2-trifluoro- 
               
               
                   
                 N′-hydroxyacetimidamide 
               
               
                 1-50 
                 100 mg (0.30 mmol) of N- 
                 48 μl (1.20 mmol) 
                 91 mg (0.33 
                 Ethanol 
                 50° C., 1.5 h→ 
                 E 
                 44 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of 
                 mmol) 
                   
                 reflux, 4.5 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 cyclopropylamine 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
             
               
                 TABLE 46 
               
               
                   
               
               
                   
                   
                   
                   
                   
                 Reaction 
                   
                   
               
               
                 Compound 
                   
                   
                 Base and 
                   
                 temperature, 
                 Synthetic 
                 Yield 
               
               
                 No. 
                 Raw material 1 
                 Raw material 2 
                 the like 
                 Solvent 
                 Time 
                 Method 
                 (%) 
               
               
                   
               
             
            
               
                 1-114 
                 80 mg (0.30 mmol) of N- 
                 48 μl (0.36 mmol) 
                 73 mg (0.33 
                 Ethanol 
                 50° C., 
                 E 
                 52 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of 2- 
                 mmol) of silver 
                   
                 3.5 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 phenyloxyethylamine 
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-44 
                 80 mg (0.30 mmol) of N- 
                 60 μl (0.72 mmol) 
                 73 mg (0.33 
                 Ethanol 
                 50° C., 
                 E 
                 55 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of n-propylamine 
                 mmol) of silver 
                   
                 2 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                   
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-118 
                 100 mg (0.30 mmol) of N- 
                 62 μl (0.60 mmol) 
                 91 mg (0.33 
                 Ethanol 
                 50° C., 
                 E 
                 70 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of 2- 
                 mmol) of silver 
                   
                 5 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 aminomethylpyridine 
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-119 
                 100 mg (0.30 mmol) of N- 
                 62 μl (0.60 mmol) 
                 91 mg (0.33 
                 Ethanol 
                 50° C., 
                 E 
                 58 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of 3- 
                 mmol) of silver 
                   
                 5 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 aminomethylpyridine 
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-47 
                 100 mg (0.30 mmol) of N- 
                 44 mg (0.60 mmol) 
                 91 mg (0.33 
                 Ethanol 
                 50° C., 
                 E 
                 49 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of n-butylamine 
                 mmol) of silver 
                   
                 5 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                   
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-55 
                 100 mg (0.30 mmol) of N- 
                 CH2═CHCH2NH2 
                 91 mg (0.33 
                 Ethanol 
                 50° C., 2 h→ 
                 E 
                 53 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 34 mg (0.60 mmol) 
                 mmol) of silver 
                   
                 reflux, 1 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                   
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-122 
                 100 mg (0.30 mmol) of N- 
                 H2NCH2-(2-thienyl) 
                 91 mg (0.33 
                 Ethanol 
                 50° C., 2 h→ 
                 E 
                 30 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 68 mg(0.60 mmol) 
                 mmol) of silver 
                   
                 reflux, 1 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                   
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-45 
                 100 mg (0.30 mmol) of N- 
                 70 mg (1.20 mmol) 
                 91 mg (0.33 
                 Ethanol 
                 50° C., 2 h→ 
                 E 
                 35 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of isopropylamine 
                 mmol) of silver 
                   
                 reflux, 5 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                   
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-124 
                 100 mg (0.30 mmol) of N- 
                 H2NCH2-(2-furanyl) 
                 91 mg (0.33 
                 Ethanol 
                 50° C., 
                 E 
                 56 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 58 mg(0.60 mmol) 
                 mmol) of silver 
                   
                 2.5 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                   
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-126 
                 100 mg (0.30 mmol) of N- 
                 H2NCH2-(2- 
                 91 mg (0.33 
                 Ethanol 
                 50° C., 
                 E 
                 43 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 tetrahyldrofuranyl) 
                 mmol) of silver 
                   
                 1 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 61 mg(0.60 mmol) 
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-64 
                 100 mg (0.30 mmol) of N- 
                 110 mg (1.20 mmol) 
                 91 mg (0.33 
                 Ethanol 
                 50° C., 1 h→ 
                 E 
                 22 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of aminoacetonitrile 
                 mmol) of silver 
                   
                 reflux, 6 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 hydrochloride 
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-146 
                 100 mg (0.30 mmol) of N- 
                 CH3OCH2CH2NH2 
                 91 mg (0.33 
                 Ethanol 
                 50° C., 
                 E 
                 30 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 45 mg(0.60 mmol) 
                 mmol) of silver 
                   
                 5 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                   
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-52 
                 100 mg (0.30 mmol) of N- 
                 51 mg (0.60 mmol) 
                 91 mg (0.33 
                 Ethanol 
                 50° C., 
                 E 
                 30 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of cyclopentylamine 
                 mmol) of silver 
                   
                 4 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                   
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-121 
                 100 mg (0.30 mmol) of N- 
                 65 mg (0.60 mmol) 
                 91 mg (0.33 
                 Ethanol 
                 60° C., 
                 E 
                 33 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of 4-aminomethyl 
                 mmol) of silver 
                   
                 4 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                 pyridine 
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
             
               
                 TABLE 47 
               
               
                   
               
               
                   
                   
                   
                   
                   
                 Reaction 
                   
                   
               
               
                 Compound 
                   
                   
                 Base and 
                   
                 temperature, 
                 Synthetic 
                 Yield 
               
               
                 No. 
                 Raw material 1 
                 Raw material 2 
                 the like 
                 Solvent 
                 Time 
                 Method 
                 (%) 
               
               
                   
               
             
            
               
                 1-53 
                 100 mg (0.30 mmol) of N- 
                 59 mg (0.60 mmol) 
                 91 mg (0.33 
                 Ethanol 
                 60° C., 
                 E 
                 28 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of cyclohexylamine 
                 mmol) of silver 
                   
                 2 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                   
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                 1-76 
                 100 mg (0.30 mmol) of N- 
                 73 mg (0.60 mmol) 
                 91 mg (0.33 
                 Ethanol 
                 60° C., 
                 E 
                 60 
               
               
                   
                 [1-((6-chloropyridin-3- 
                 of phenethylamine 
                 mmol) of silver 
                   
                 4 h 
               
               
                   
                 yl)methyl)pyridin-2(1H)- 
                   
                 carbonate 
               
               
                   
                 ylidene]-2,2,2- 
               
               
                   
                 trifluoroethanethioamide 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 48 
               
               
                   
               
               
                 Compound 
                   
                 MS or IR 
               
               
                 No. 
                 1H-NMR (CDCl3, δ, ppm) 
                 (KBr, v, cm −1 ) 
               
               
                   
               
             
            
               
                 266-2 
                 5.62 (2H. s). 7.33 (1H, d), 7.83 
                 m/z = 323 
               
               
                   
                 (1H, d). 8.57 (2H, m) 
                 (M + H) 
               
               
                 444-2 
                 5.73 (2H, s). 7.69 (1H, s), 8.56 
                 m/z = 329 
               
               
                   
                 (1H, s) 
                 (M + H) 
               
               
                 190-2 
                 5.39 (2H, s), 6.87 (1H, dd), 
                 m/z = 317 
               
               
                   
                 7.36 (1H, d), 7.91 (1H, dd), 
                 (M + H) 
               
               
                   
                 8.39 (1H, d), 8.49 (1H, s). 8.79 
               
               
                   
                 (1 H, d) 
               
               
                 201-2 
                 5.45 (2H, s), 7.37 (1H, d), 7.65 
                 m/z = 317 
               
               
                   
                 (1H, d), 7.87 (1H, dd), 7.99 
                 (M + H) 
               
               
                   
                 (1H, d), 8.49 (1H, d), 9.80 (1 H, 
               
               
                   
                 d) 
               
               
                 223-2 
                 5.69 (2H, s), 7.31 (1H, d), 7.55 
                 m/z = 317 
               
               
                   
                 (1H, dd), 7.92 (1H, dd), 8.28 
                 (M + H) 
               
               
                   
                 (1H, dd), 8.59 (1H, d), 8.78 
               
               
                   
                 (1H, dd) 
               
               
                 146-2 
                 5.64 (2H, s), 7.14 (1H, dd), 
                 m/z = 332 
               
               
                   
                 7.33 (1H, d), 7.47 (1H, dd), 
                 (M + H) 
               
               
                   
                 7.71 (1H, dd), 7.74 (1H, dd), 
               
               
                   
                 8.42 (1H, d), 11.64 (1H, br s) 
               
               
                 224-2 
                 5.78 (2H, s), 7.57, 7.63 (1H, 
                 m/z = 323 
               
               
                   
                 dd × 2), 7.70 (1H, s), 8.26, 8.41 
                 (M + H) 
               
               
                   
                 (1H, dd × 2), 8.82, 9.04 (1H, 
               
               
                   
                 dd × 2) 
               
               
                 102-2 
                 5.56 (2H, s), 7.15 (1H, m), 7.38 
                 m/z = 341 
               
               
                   
                 (1H, d), 7.84 (1H, dd), 8.26 
                 (M + H) 
               
               
                   
                 (1H, dd), 8.48 (1H, d), 8.60 
               
               
                   
                 (1H, d) 
               
               
                 212-2 
                 5.43 (2H, s), 7.35 (1H, d), 7.87 
                 m/z = 317 
               
               
                   
                 (1H, dd), 8.20 (1H, d), 8.29 
                 (M + H) 
               
               
                   
                 (1H, d), 8.51 (1H, d), 8.77 (1H, 
               
               
                   
                 s) 
               
               
                 1-20 
                 5.48 (2H, s), 7.12 (1H, td), 
                 m/z = 332 
               
               
                   
                 7.34 (1H, d), 7.77 (1H, dd), 
                 (M + H) 
               
               
                   
                 7.96 (1H, m), 8.05 (1H, dd), 
               
               
                   
                 8.45 (1H, d), 8.56 (1H, d) 
               
               
                 12-2 
                 5.54 (2H, s), 6.96 (1H, m), 7.21 
                 m/z = 316 
               
               
                   
                 (1H, d), 7.87 (1H, m), 7.97 (1H, 
                 (M + H) 
               
               
                   
                 m), 8.34 (1H, d), 8.50 (1H, d) 
               
               
                 213-2 
                 5.51 (2H, s), 7.69 (1H, s), 8.25 
                 m/z = 323 
               
               
                   
                 (1H, d), 8.30 (1H, d), 8.57 (1H, 
                 (M + H) 
               
               
                   
                 s) 
               
               
                 1-17 
                 4.52 (2H, q), 5.44 (2H, s), 6.85 
                 m/z = 346 
               
               
                   
                 (1H, td), 7.31 (1H, d), 7.57 (2H, 
                 (M + H) 
               
               
                   
                 m), 7.79 (1H, dd), 8.14 (1H, d), 
               
               
                   
                 8.40 (1H, d) 
               
               
                 1-18 
                 1.44 (3H, d), 5.31 (1H, m), 5.42 
                 m/z = 360 
               
               
                   
                 (2H, q), 6.54 (1H, td), 7.30 (1H, 
                 (M + H) 
               
               
                   
                 d), 7.53 (2H, m), 7.79 (1H, dd), 
               
               
                   
                 8.10 (1H, d), 8.40 (1H, d) 
               
               
                 1-19 
                 5.47 (2H, s), 5.81 (1H, m), 6.69 
                 m/z = 414 
               
               
                   
                 (1H, m), 7.31 (1H, d), 7.65 (1H, 
                 (M + H) 
               
               
                   
                 m), 7.68 (1H, dd), 7.85 (1H, dd), 
               
               
                   
                 8.17 (1H, d), 8.40 (1H, d) 
               
               
                 7-2 
                 5.57 (2H, s), 6.91 (1H, m), 7.80 
               
               
                   
                 (1H, m), 8.10 (1H, m), 8.47 (1H, 
               
               
                   
                 s), 8.49 (1H, d), 8.72 (1H, d) 
               
               
                 1-13 
                 3.22 (2H, q), 5.46 (2H, s), 6.65 
                 m/s = 330 
               
               
                   
                 (1H, td), 7.31 (1H, d), 7.62 (1H, 
                 (M + H) 
               
               
                   
                 m), 7.66 (1H, dd), 7.70 (1H, dd), 
               
               
                   
                 8.35 (1H, d), 8.41 (1H, d) 
               
               
                 168-2 
                 5.11 (2H, s), 7.40 (2H, m), 7.75 
                 m/z = 332.0426 
               
               
                   
                 (1H, dd), 8.09 (1H, d), 8.15 (1H, 
                 (M + H) 
               
               
                   
                 d), 8.46 (1H, d), 8.81 (1H, br s) 
               
               
                 1-21 
                 5.49 (2H, s), 6.21 (1H, t), 7.05 
                 m/z = 314.0346 
               
               
                   
                 (1H, td), 7.34 (1H, d), 7.82 (1H, 
                 (M + H) 
               
               
                   
                 dd), 7.90 (1H, m), 7.94 (1H, dd), 
               
               
                   
                 8.45 (1H, d), 8.49 (1H, d) 
               
               
                 3-20 
                 5.51 (2H, s), 6.95 (1H, d), 7.15 
                 m/z = 316.0559 
               
               
                   
                 (1H, td), 7.96 (2H, m), 8.09 (1H, 
                 (M + H) 
               
               
                   
                 d), 8.29 (1H, d), 8.52 (1H, d) 
               
               
                 4-20 
                 5.47 (2H, s), 7.13 (1H, m), 7.50 
                 m/z = 375.9 
               
               
                   
                 (1H, m), 7.66 (1H, m), 7.97 (1H, 
                 (M + H) 
               
               
                   
                 m), 8.07 (1H, m), 8.43 (1 H, s), 
               
               
                   
                 8.54 (1H, m) 
               
               
                 3-3 
                 5.54 (2H, s), 5.92 (1H, t), 6.79 
               
               
                   
                 (1H, td), 6.94 (1H, dd), 7.70 
               
               
                   
                 (1H, m), 7.78 (1H, dd), 8.03 (1H, 
               
               
                   
                 td), 8.30 (1H, d), 8.50 (1H, d) 
               
               
                 4-3 
                 5.50 (2H, s), 5.90 (1H, t), 6.79 
                 m/z = 342 
               
               
                   
                 (1H, m), 7.48 (1H, d), 7.74 (3H, 
                 (M + H) 
               
               
                   
                 m), 8.43 (1H, d), 8.50 (1H, d) 
               
               
                 5-5 
                 5.56 (2H, s), 6.91 (1H, m), 7.69 
                 m/z = 384.0372 
               
               
                   
                 (1H, dd), 7.82 (2H, m), 8.26 (1H, 
                 (M + H) 
               
               
                   
                 d), 8.60 (1H, d) 
               
               
                 6-5 
                 5.52 (2H, s), 6.93 (1H, m), 7.86 
                 m/z = 367.0687 
               
               
                   
                 (2H, m). 8.61 (1H, d), 8.75 (2H, 
                 (M + H) 
               
               
                   
                 s) 
               
               
                 1-22 
                 5.49 (2H, s), 7.09 (1H, td), 
                 m/z = 347.9972 
               
               
                   
                 7.35 (1H, d), 7.78 (1H, dd), 
                 (M + H) 
               
               
                   
                 7.95 (2H, m), 8.46 (1H, d), 8.55 
               
               
                   
                 (1H, d) 
               
               
                 1-23 
                 5.47 (2H, s), 7.10 (1H, td), 
                 m/z = 382.0246 
               
               
                   
                 7.34 (1H, d), 7.68 (1H, dd), 
                 (M + H) 
               
               
                   
                 7.95 (2H, m), 8.41 (1H. d), 8.55 
               
               
                   
                 (1 H, dd) 
               
               
                 5-20 
                 5.49 (2H, s), 7.10 (1H, m), 7.65 
                 m/z = 350.0188 
               
               
                   
                 (1H, dd), 7.96 (1H, m), 8.00 
                 (M + H) 
               
               
                   
                 (1H, m), 8.27 (1H, d), 8.63 (1H, 
               
               
                   
                 d) 
               
               
                 5-3 
                 5.53 (2H, s), 5.90 (1H, t), 6.80 
                 m/z = 316.0507 
               
               
                   
                 (1H, td), 7.76 (2H, m), 8.29 
                 (M + H) 
               
               
                   
                 (1H, d), 8.52 (1H, d) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 49 
               
               
                   
               
               
                 Compound 
                   
                 MS or IR 
               
               
                 No. 
                 1H-NMR (CDCl3, δ, ppm) 
                 (KBr, v, cm −1 ) 
               
               
                   
               
             
            
               
                 6-3 
                 5.45 (2H, s), 5.89 (1H, t), 6.83 
                 m/z = 299.0532 
               
               
                   
                 (1H, td), 7.75 (1H, m), 7.82 
                 (M + H) 
               
               
                   
                 (1H, dd), 8.52 (1H, d), 8.81 
               
               
                   
                 (2H, s) 
               
               
                 8-2 
                 5.73 (2H, s), 6.90 (1H, td), 
               
               
                   
                 7.54 (1H, d), 7.81 (1H, td), 
               
               
                   
                 7.97 (1H, d), 8.22 (1H, d), 8.53 
               
               
                   
                 (1H, d) 
               
               
                 5-4 
                 5.54 (2H, s), 6.86 (1H, td), 
                 m/z = 350.0082 
               
               
                   
                 7.99 (3H, m), 8.30 (1H, d), 8.54 
                 (M + H) 
               
               
                   
                 (1H, d) 
               
               
                 4-4 
                 5.52 (2H, s), 6.86 (1H, td), 
                 m/z = 375.96 
               
               
                   
                 7.49 (1H, d), 7.77 (2H, m), 7.83 
                 (M + H) 
               
               
                   
                 (1H, dd), 8.45 (1H, d), 8.52 
               
               
                   
                 (1H, d) 
               
               
                 6-4 
                 5.49 (2H, s), 6.90 (1H, td), 
                 m/z = 333.0121 
               
               
                   
                 7.82 (1H, td), 7.87 (1H, dd), 
                 (M + H) 
               
               
                   
                 8.54 (1H, d), 8.81 (2H, s) 
               
               
                 4-5 
                 5.53 (2H, s), 6.89 (1H, td), 
                 m/z = 410 
               
               
                   
                 7.48 (1H, d), 7.70 (1H, dd), 
                 (M + H) 
               
               
                   
                 7.82 (2H, m), 8.41 (1H, d), 8.58 
               
               
                   
                 (1H, d) 
               
               
                 2-20 
                 5.57 (2H, s), 7.12 (1H, m), 7.68 
                 m/z = 338 
               
               
                   
                 (1H, s), 7.97 (1H, m), 8.12 (1H, 
                 (M + H) 
               
               
                   
                 d), 8.67 (1H, d) 
               
               
                 10-20 
                 5.58 (2H, s), 7.12 (1H, m), 7.70 
                 m/z = 366 
               
               
                   
                 (1H, d), 7.97 (2H, m), 8.02 (1H, 
                 (M + H) 
               
               
                   
                 d), 8.62 (1H, d), 8.77 (1H, s) 
               
               
                 3-4 
                 5.55 (2H, s), 6.86 (1H, td), 
                 m/z = 316 
               
               
                   
                 6.95 (1H, dd), 7.77 (1H, td), 
                 (M + H) 
               
               
                   
                 7.85 (1H, dd), 8.06 (1H, td), 
               
               
                   
                 8.31 (1H, d), 8.53 (1H, d) 
               
               
                 3-5 
                 5.56 (2H, s), 6.89 (1H, m), 6.94 
                 m/z = 350 
               
               
                   
                 (1H, dd), 7.80 (2H, m), 7.97 
                 (M + H) 
               
               
                   
                 (1H, td), 8.27 (1H, d), 8.58 
               
               
                   
                 (1H, d) 
               
               
                 11-20 
                 1.69 (1H, m), 2.07 (1H, m), 2.84 
                 m/z = 291 
               
               
                   
                 (1H, m), 3.59 (1H, dd), 3.71 
                 (M + H) 
               
               
                   
                 (1H, dd), 3.77 (1H, m), 3.96 
               
               
                   
                 (1H, m), 4.13 (1H, dd), 4.42 
               
               
                   
                 (1H, dd), 7.11 (1H, m), 7.92 
               
               
                   
                 (1H, dd), 7.98 (1H, m), 8.40 
               
               
                   
                 (1H, d) 
               
               
                 1-14 
                 5.44 (2H, s), 5.61 (1H, dd), 
                 m/z = 274 
               
               
                   
                 6.28 (1H, dd), 6.36 (1H, dd), 
                 (M + H) 
               
               
                   
                 6.52 (1H, m), 7.30 (1H, d), 7.52 
               
               
                   
                 (1H, m), 7.57 (1H, d), 7.73 (1H, 
               
               
                   
                 dd), 8.28 (1H, d), 8.44 (1H, d) 
               
               
                 1-37 
                 1.28 (3H, t), 2.88 (2H, q), 5.41 
                 m/z = 292 
               
               
                   
                 (2H, s), 6.86 (1H, t), 7.35 (1H, 
                 (M + H) 
               
               
                   
                 d), 7.75 (3H, m), 8.10 (1H, d), 
               
               
                   
                 8.44 (1H, d) 
               
               
                 1-39 
                 1.26 (6H, d), 2.55 (1H, m), 5.51 
                 m/z = 306 
               
               
                   
                 (2H, s), 6.98 (1H, m), 7.36 (1H, 
                 (M + H) 
               
               
                   
                 d), 7.76 (1H, dd), 7.77 (2H, m), 
               
               
                   
                 8.08 (1H, d), 8.44 (1H, d) 
               
               
                 1-40 
                 0.92 (2H, m), 1.22 (2H, m), 2.40 
                 m/z = 304 
               
               
                   
                 (1H, m), 5.36 (2H, s), 6.77 (1H, 
                 (M + H) 
               
               
                   
                 td), 7.34 (1H, d), 7.66 (2H, m), 
               
               
                   
                 7.71 (1H, dd), 8.14 (1H, d), 
               
               
                   
                 8.41 (1H, d) 
               
               
                 1-15 
                 5.08 (2H, d), 5.40 (2H, s), 5.84 
                 m/z = 286 
               
               
                   
                 (1H, t), 6.50 (1H, m), 7.30 (1H, 
                 (M + H) 
               
               
                   
                 d), 7.50 (1H, m), 7.56 (1H, m), 
               
               
                   
                 7.80 (1H, dd), 8.25 (1H, d), 
               
               
                   
                 8.47 (1H, d) 
               
               
                 1-35 
                 3.18 (4H, m), 5.05 (2H, s), 6.83 
                 m/z = 368 
               
               
                   
                 (1H, td), 7.05 (1H, t), 7.25 
                 (M + H) 
               
               
                   
                 (2H, m), 7.38 (3H, m), 7.59 (1H, 
               
               
                   
                 dd), 7.67 (1H, d), 7.72 (1H, 
               
               
                   
                 td), 7.99 (1H, d), 8.30 (1H, d) 
               
               
                 1-501 
                 1.20 (3H, t), 4.10 (2H, q), 5.22 
                 m/z = 359 
               
               
                   
                 (2H, s), 6.15 (1H, td), 6.27 
                 (M + H) 
               
               
                   
                 (1H, d), 7.13 (1H, m), 7.27 (2H, 
               
               
                   
                 m), 7.79 (1H, dd), 8.37 (1H, d) 
               
               
                 1-499 
                 5.26 (2H, s), 6.11 (1H, d), 6.31 
                 m/z = 331 
               
               
                   
                 (1H, m), 7.31 (1H, m), 7.50 (1H, 
                 (M + H) 
               
               
                   
                 d), 7.83 (1H, dd), 7.90 (1H, 
               
               
                   
                 dd), 8.44 (1H, d), 11.0 (1H, s) 
               
               
                 1-510 
                 5.07 (2H, s), 5.19 (2H, s), 6.13 
                 m/z = 421 
               
               
                   
                 (1H, td), 6.22 (1H, d), 7.07 
                 (M + H) 
               
               
                   
                 (1H, m), 7.18-7.40 (8H, m), 7.69 
               
               
                   
                 (1H, dd), 8.34 (1H, d) 
               
               
                 1-511 
                 1.99 (3H, s), 5.27 (2H, s), 6.37 
                 m/z = 373 
               
               
                   
                 (2H, m), 7.31 (2H, m), 7.44 (1H, 
                 (M + H) 
               
               
                   
                 dd), 7.76 (1H, dd), 8.37 (1H, d) 
               
               
                 1-519 
                 5.31 (2H, s), 6.36 (1H, t), 6.51 
                 m/z = 435 
               
               
                   
                 (1H, d), 7.17 (1H, d), 7.25 (4H, 
                 (M + H) 
               
               
                   
                 m), 7.50 (3H, m), 7.78 (1H, dd), 
               
               
                   
                 8.41 (1H, d) 
               
               
                 1-523 
                 3.84 (3H, s), 5.26 (2H, s), 6.35 
                 m/z = 389 
               
               
                   
                 (1H, m), 6.40 (1H, d), 7.30 (2H, 
                 (M + H) 
               
               
                   
                 m), 7.37 (1H, dd), 7.73 (1H, 
               
               
                   
                 dd), 8.37 (1H, d) 
               
               
                 1-528 
                 3.14 (3H, s), 5.27 (2H, s), 6.44 
                 m/z = 409 
               
               
                   
                 (1H, td), 6.54 (1H, dd), 7.32 
                 (M + H) 
               
               
                   
                 (1H, d), 7.41 (2H, m), 7.68 (1H, 
               
               
                   
                 dd), 8.39 (1H, d) 
               
               
                 1-531 
                 2.45 (3H, s), 5.23 (2H, s), 6.37 
                 m/z = 485 
               
               
                   
                 (1H, d), 6.42 (1H, td), 7.29 
                 (M + H) 
               
               
                   
                 (4H, m), 7.45 (1H, d), 7.70 (1H, 
               
               
                   
                 dd), 7.80 (2H, d), 8.35 (1H, d) 
               
               
                 1-507 
                 4.54 (2H, m), 5.16 (2H, m), 5.22 
                 m/z = 371 
               
               
                   
                 (2H, s), 5.91 (1H, m), 6.17 (1H, 
                 (M + H) 
               
               
                   
                 td), 6.29 (1H, d), 7.15 (1H, m), 
               
               
                   
                 7.27 (2H, m), 7.79 (1H, dd), 
               
               
                   
                 8.37 (1H, d) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 50 
               
               
                   
               
               
                 Compound 
                   
                 MS or IR 
               
               
                 No. 
                 1H-NMR (CDCl3, δ, ppm) 
                 (KBr, v, cm −1 ) 
               
               
                   
               
             
            
               
                 1-516 
                 5.27 (2H, s), 5.76 (1H, dd), 5.91 
                 m/z = 385 
               
               
                   
                 (1H, dd), 6.22 (1H, dd), 6.36 (1H, 
                 (M + H) 
               
               
                   
                 m), 6.42 (1H, d), 7.29 (2H, m), 7.42 
               
               
                   
                 (1H, d), 7.76 (1H, dd), 8.37 (1H, d) 
               
               
                 1-518 
                 1.25 (1H, s), 1.98 (2H, s), 5.28 
                 m/z = 397 
               
               
                   
                 (2H, s), 6.38 (2H, m), 7.30 (2H, m), 
                 (M + H) 
               
               
                   
                 7.41 (1H, d), 7.75 (1H, dd), 8.38 
               
               
                   
                 (1H, d) 
               
               
                 1-527 
                 5.28 (2H, s), 6.39 (1H, m), 6.50 
                 m/z = 451 
               
               
                   
                 (1H, d), 7.13 (1H, d), 7.22-7.41 
                 (M + H) 
               
               
                   
                 (7H, m), 7.76 (1H, dd), 8.40 (1H, d) 
               
               
                 1-521 
                 5.30 (2H, s), 6.42 (1H, t), 6.52 
                 m/z = 436 
               
               
                   
                 (1H, d), 7.20 (1H, d), 7.32 (2H, m), 
                 (M + H) 
               
               
                   
                 7.53 (1H, dd), 7.75 (1H, dd), 8.01 
               
               
                   
                 (1H, dd), 8.41 (1H, d), 8.54 (1H, 
               
               
                   
                 d), 8.71 (1H. dd) 
               
               
                 1-43 
                 1.13 (3H, t), 3.03 (2H, q), 5.15 (2H, 
                 m/z = 343 
               
               
                   
                 s), 6.12 (1H, m), 6.19 (1H, d), 
                 (M + H) 
               
               
                   
                 7.14 (1H, m), 7.27 (1H, m), 7.33 (1H, 
               
               
                   
                 d), 7.72 (1H, dd), 8.37 (1H, d) 
               
               
                 1-536 
                 4.48 (2H, d), 5.25 (2H, s), 6.36 
                 m/z = 464 
               
               
                   
                 (1H, td), 6.41 (1H, d), 6.79 (1H, 
                 (M + H) 
               
               
                   
                 m), 7.41 (7H, m), 7.73 (1H, dd), 
               
               
                   
                 8.40 (1H, d) 
               
               
                 1-42 
                 2.86 (3H, s), 5.16 (2H, s), 6.15 
                 m/z = 329 
               
               
                   
                 (2H, m), 7.16 (1H, m), 7.26 (1H, 
                 (M + H) 
               
               
                   
                 dd), 7.31 (1H, d), 7.73 (1H, dd), 
               
               
                   
                 8.38 (1H, d) 
               
               
                 1-500 
                 3.86 (3H, s), 5.22 (2H, s), 6.17 
                 m/z = 345 
               
               
                   
                 (1H, m), 6.26 (1H, d), 7.14 (1H, m), 
                 (M + H) 
               
               
                   
                 7.23 (1H, dd), 7.30 (1H, d), 7.78 
               
               
                   
                 (1H, dd), 8.39 (1H, d) 
               
               
                 1-504 
                 1.23 (9H, s), 5.23 (2H, s), 6.10 
                 m/z = 387 
               
               
                   
                 (1H, m), 6.22 (1H, d), 7.09 (1H, m), 
                 (M + H) 
               
               
                   
                 7.20 (1H, dd), 7.26 (1H, m), 7.79 
               
               
                   
                 (1H, dd), 8.35 (1H, d) 
               
               
                 1-534 
                 0.95 (3H, t), 1.61 (2H, m), 3.23 
                 m/z = 416 
               
               
                   
                 (2H, t), 5.24 (2H, s), 6.32 (1H, t), 
                 (M + H) 
               
               
                   
                 6.39 (1H, d), 6.48 (1H, m), 7.33 (3H, 
               
               
                   
                 m), 7.74 (1H, dd), 8.40 (1H, d) 
               
               
                 1-535 
                 3.65 (4H, m), 5.25 (2H, s), 6.36 
                 m/z = 436 
               
               
                   
                 (1H, t), 6.41 (1H, d), 6.82 (1H, 
                 (M + H) 
               
               
                   
                 m), 7.36 (3H, m), 7.74 (1H, dd), 
               
               
                   
                 8.41 (1H, d) 
               
               
                 1-72 
                 4.22 (2H, s), 5.13 (2H, s), 6.14 
                 m/z = 405 
               
               
                   
                 (1H, m), 6.21 (1H, d), 7.13 (1H, 
                 (M + H) 
               
               
                   
                 m), 7.26 (7H, m), 7.68 (1H, dd), 
               
               
                   
                 8.36 (1H, d) 
               
               
                 1-150 
                 2.08 (3H, s), 2.70 (2H, t), 3.22 
                 m/z = 389 
               
               
                   
                 (2H, t), 5.15 (2H, s), 6.16 (1H, 
                 (M + H) 
               
               
                   
                 t), 6.22 (1H, d), 7.17 (1H, m), 
               
               
                   
                 7.29 (1H, d), 7.33 (1H, d), 7.70 
               
               
                   
                 (1H, dd), 8.38 (1H, d) 
               
               
                 1-67 
                 3.13 (2H, m), 3.73 (2H, t), 5.15 
                 m/z = 359 
               
               
                   
                 (2H, s), 6.18 (2H, m), 7.17 (1H, 
                 (M + H) 
               
               
                   
                 m), 7.33 (2H, m), 7.71 (1H, dd), 
               
               
                   
                 8.37 (1H, d) 
               
               
                 1-515 
                 0.82 (2H, m), 0.93 (2H, m), 1.40 
                 m/z = 399 
               
               
                   
                 (1H, m), 5.27 (2H, s), 6.35 (1H, 
                 (M + H) 
               
               
                   
                 m), 6.42 (1H, d), 7.31 (2H, m), 
               
               
                   
                 7.41 (1H, d), 7.77 (1H, dd), 
               
               
                   
                 8.38 (1H, d) 
               
               
                 1-56 
                 2.13 (1H, t), 3.85 (2H, d), 5.18 
                 m/z = 353 
               
               
                   
                 (2H, s), 6.21 (1H, t), 6.25 (1H, 
                 (M + H) 
               
               
                   
                 d), 7.18 (1H, m), 7.29 (1H, d), 
               
               
                   
                 7.33 (1H, d), 7.70 (1H, dd), 
               
               
                   
                 8.38 (1H, d) 
               
               
                 1-512 
                 1.02 (3H, t), 2.23 (2H, q), 5.26 
                 m/z = 387 
               
               
                   
                 (2H, s), 6.34 (1H, m), 6.39 (1H, 
                 (M + H) 
               
               
                   
                 m), 7.29 (2H, m), 7.40 (1H, d), 
               
               
                   
                 7.75 (1H, dd), 8.37 (1H, d) 
               
               
                 1-514 
                 0.97 (6H, s), 2.37 (1H, m), 5.26 
                 m/z = 399 
               
               
                   
                 (2H, s), 6.35 (1H, m), 6.40 (1H, 
                 (M + H) 
               
               
                   
                 d), 7.27 (2H, m), 7.42 (1H, dd), 
               
               
                   
                 7.77 (1H, dd), 8.38 (1H, d) 
               
               
                 1-50 
                 0.74 (2H, m), 0.85 (2H, m), 2.51 
                 m/z = 355 
               
               
                   
                 (1H, m), 5.18 (2H, s), 6.12 (1H, 
                 (M + H) 
               
               
                   
                 m), 6.30 (1H, d), 7.15 (1H, m), 
               
               
                   
                 7.27 (1H, m), 7.31 (1H, d), 7.79 
               
               
                   
                 (1H, dd), 8.39 (1H, d) 
               
               
                 1-114 
                 3.44 (2H, td), 4.18 (2H, t), 
                 m/z = 435 
               
               
                   
                 5.14 (2H, s), 6.15 (1H, td), 
                 (M + H) 
               
               
                   
                 6.26 (1H, d), 6.86 (2H, d), 6.92 
               
               
                   
                 (1H, m), 7.16 (1H, m), 7.28 (4H, 
               
               
                   
                 m), 7.71 (1H, dd), 8.38 (1H, d) 
               
               
                 1-44 
                 0.83 (3H, t), 1.55 (2H, m), 2.91 
                 m/z = 357 
               
               
                   
                 (2H, m), 5.14 (2H, s), 6.12 (1H, 
                 (M + H) 
               
               
                   
                 td), 6.18 (1H, d), 7.13 (1H, m), 
               
               
                   
                 7.30 (2H, m), 7.71 (1H, dd), 
               
               
                   
                 8.36 (1H, d) 
               
               
                 1-118 
                 4.41 (2H, s), 5.15 (2H, s), 6.18 
                 m/z = 406 
               
               
                   
                 (1H, t), 6.24 (1H, d), 7.14 (2H, 
                 (M + H) 
               
               
                   
                 m), 7.26 (2H, m), 7.54 (1H, d), 
               
               
                   
                 7.68 (1H, dd), 7.71 (1H, dd), 
               
               
                   
                 8.38 (1H, d), 8.47 (1H, d) 
               
               
                 1-119 
                 4.22 (2H, s), 5.16 (2H, s), 6.20 
                 m/z = 406 
               
               
                   
                 (2H, m), 7.15-7.30 (3H, m), 7.34 
                 (M + H) 
               
               
                   
                 (1H, dd), 7.61 (1H, d), 7.79 
               
               
                   
                 (1H, dd), 8.37 (1H, d), 8.42 
               
               
                   
                 (1H, d), 8.46 (1H, d) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 51 
               
               
                   
               
               
                 Compound 
                   
                 MS or IR 
               
               
                 No. 
                 1H-NMR (CDCl3, δ, ppm) 
                 (KBr, v, cm −1 ) 
               
               
                   
               
             
            
               
                 1-47 
                 0.85 (3H, t), 1.25 (2H, m), 1.53 
                 m/z = 371 
               
               
                   
                 (2H, m), 2.96 (2H, m), 5.14 (2H, 
                 (M + H) 
               
               
                   
                 s), 6.10 (1H, m), 6.17 (1H, d), 
               
               
                   
                 6.99 (1H, m), 7.27 (2H, m), 7.70 
               
               
                   
                 (1H, dd), 8.36 (1H, d) 
               
               
                 1-55 
                 3.65 (2H, m), 5.04 (2H, m), 5.15 
                 m/z = 355 
               
               
                   
                 (2H, s), 5.90 (1H, m), 6.13 (1H, 
                 (M + H) 
               
               
                   
                 m), 6.20 (1H, d), 7.13 (1H, m), 
               
               
                   
                 7.28 (2H, m), 7.71 (1H, dd), 
               
               
                   
                 8.36 (1H, d) 
               
               
                 1-122 
                 4.41 (2H, s), 5.17 (2H, s), 6.17 
                 m/z = 411 
               
               
                   
                 (2H, m), 6.82 (1H, m), 6.91 (1H, 
                 (M + H) 
               
               
                   
                 m), 7.16 (2H, m), 7.30 (2H, m), 
               
               
                   
                 7.70 (1H, dd), 8.38 (1H, d) 
               
               
                 1-45 
                 1.02 (6H, d), 3.34 (1H, m), 5.13 
                 m/z = 357 
               
               
                   
                 (2H, s), 6.10 (1H, m), 6.24 (1H, 
                 (M + H) 
               
               
                   
                 d), 7.11 (1H, m), 7.26 (1H, m), 
               
               
                   
                 7.31 (1H, d), 7.68 (1H, dd), 
               
               
                   
                 8.35 (1H, d) 
               
               
                 1-124 
                 4.20 (2H, s), 5.17 (2H, s), 
                 m/z = 395 
               
               
                   
                 6.13-6.29 (4H, m), 7.17 (1H, m), 
                 (M + H) 
               
               
                   
                 7.30 (3H, m), 7.71 (1H, dd), 
               
               
                   
                 8.38 (1H, d) 
               
               
                 1-126 
                 1.49 (1H, m), 1.84 (2H, m), 1.99 
                 m/z = 399 
               
               
                   
                 (1H, m), 2.98 (1H, ddd), 3.14 
                 (M + H) 
               
               
                   
                 (1H, ddd), 3.73 (2H, m), 4.09 
               
               
                   
                 (1H, m), 5.13 (2H, m), 6.13 (1H, 
               
               
                   
                 m), 6.20 (1H, d), 7.14 (1H, m), 
               
               
                   
                 7.30 (2H, m), 7.70 (1H, dd), 
               
               
                   
                 8.37 (1H, d) 
               
               
                 1-64 
                 4.01 (2H, s), 5.24 (2H, s), 6.34 
                 m/z = 354 
               
               
                   
                 (2H, m), 7.34 (2H, m), 7.41 (1H, 
                 (M + H) 
               
               
                   
                 dd), 7.66 (1H, dd), 8.36 (1H, d) 
               
               
                 1-146 
                 3.21 (2H, m), 3.34 (2H, s), 3.57 
                 m/z = 373 
               
               
                   
                 (2H, t), 5.14 (2H, s), 6.15 (1H, 
                 (M + H) 
               
               
                   
                 m), 6.21 (1H, m), 7.15 (1H, m), 
               
               
                   
                 7.30 (2H, m), 7.72 (1H, dd), 
               
               
                   
                 8.37 (1H, d) 
               
               
                 1-52 
                 1.40-1.77 (8H, m), 3.48 (1H, m), 
                 m/z = 383 
               
               
                   
                 5.12 (2H, s), 6.09 (1H, m), 6.23 
                 (M + H) 
               
               
                   
                 (1H, d), 7.12 (1H, m), 7.24 (1H, 
               
               
                   
                 m), 7.31 (1H, d), 7.69 (1H, dd), 
               
               
                   
                 8.35 (1H, d) 
               
               
                 1-121 
                 4.18 (2H, s), 5.14 (2H, s), 6.20 
                 m/z = 406 
               
               
                   
                 (2H, m), 7.19 (3H, m), 7.26 (1H, 
                 (M + H) 
               
               
                   
                 m), 7.35 (1H, dd), 7.75 (1H, 
               
               
                   
                 dd), 8.36 (1H, d), 8.51 (2H, m) 
               
               
                 1-53 
                 0.98-1.72 (10H, m), 2.91 (1H, 
                 m/z = 397 
               
               
                   
                 m), 5.11 (2H, s), 6.11 (1H, td), 
                 (M + H) 
               
               
                   
                 6.24 (1H, d), 7.11 (1H, m), 7.29 
               
               
                   
                 (3H, m), 7.66 (1H, dd), 8.34 
               
               
                   
                 (1H, d) 
               
               
                 1-76 
                 2.90 (2H, t), 3.24 (2H, td), 
                 m/z = 419 
               
               
                   
                 5.07 (2H, s), 6.01 (1H, d), 6.09 
                 (M + H) 
               
               
                   
                 (1H, td), 7.02-7.30 (8H, m), 
               
               
                   
                 7.61 (1H, dd), 8.34 (1H, d) 
               
               
                 267-2 
                 4.34 (1H, d), 4.62 (1H, d), 6.40 
                 1730, 1689, 
               
               
                   
                 (1H, d), 7.20 (1H, d), 7.51 (2H, 
                 1556, 1467, 
               
               
                   
                 m), 7.59 (1H, dd), 7.63 (2H, m), 
                 1440, 1418 
               
               
                   
                 7.82 (1H, d), 8.23 (1H, d) 
               
               
                 253-2 
                 5.31 (2H, s), 7.28 (2H, m), 7.50 
                 1644, 1557, 
               
               
                   
                 (1H, d), 7.72 (3H, m), 7.85 (1H, 
                 1508, 1483 
               
               
                   
                 m), 8.25 (1H, d), 8.45 (1H, d) 
               
               
                 251-2 
                 5.20 (2H, s), 7.26 (2H, m), 7.63 
                 3065, 1696, 
               
               
                   
                 (2H, m), 7.85 (2H, m), 8.02 (1H, 
                 1463, 1403 
               
               
                   
                 d), 8.23 (2H, m) 
               
               
                 13-2 
                 5.76 (2H, s), 6.91 (1H, m), 7.46 
                 3060, 2226, 
               
               
                   
                 (1H, m), 7.60 (1H, m), 7.70 (1H, 
                 1641, 1556, 
               
               
                   
                 d), 7.80 (2H, m), 8.12 (1H, d), 
                 1509 
               
               
                   
                 8.53 (1H, d) 
               
               
                 1-1 
                 5.49 (2H, s), 6.67 (1H, m), 7.30 
                 — 
               
               
                   
                 (1H, m), 7.60 (1H, m), 7.72 (2H, 
               
               
                   
                 m), 7.81 (1H, dd), 8.42 (1H, d), 
               
               
                   
                 9.06 (1H, s) 
               
               
                 1-41 
                 5.64 (2H, s), 7.50 (2H, m), 7.70 
                 m/z = 315.16 
               
               
                   
                 (1H, d), 7.78 (1H, dd), 8.27 
                 (M + H) 
               
               
                   
                 (1H, m), 8.37 (1H, d), 8.78 (1H, 
               
               
                   
                 d) (methanol-d4) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 52 
               
               
                   
               
               
                 Compound 
                   
                 MS or IR 
               
               
                 No. 
                 1H-NMR (CDCl3, δ, ppm) 
                 (KBr, v, cm −1 ) 
               
               
                   
               
             
            
               
                 2-2 
                 2.47 (2H, m), 4.17 (2H, t), 5.07 
                 m/z = 322 
               
               
                   
                 (1H, d), 5.15 (1H, dd), 5.39 (2H, 
                 (M + H) 
               
               
                   
                 s), 5.85 (1H, m), 6.43 (1H, td), 
               
               
                   
                 7.30 (1H, d), 7.44 (2H, m), 7.75 
               
               
                   
                 (1H, dd), 8.08 (1H, d), 8.40 (1H, d) 
               
               
                 1-647 
                 2.47 (2H, m), 4.17 (2H, t), 5.07 
                 m/z = 318.1013 
               
               
                   
                 (1H, d), 5.15 (1H, dd), 5.39 (2H, 
                 (M + H) 
               
               
                   
                 s), 5.85 (1H, m), 6.43 (1H, td), 
               
               
                   
                 7.30 (1H, d), 7.44 (2H, m), 7.75 
               
               
                   
                 (1H, dd), 8.08 (1H, d), 8.40 (1H, d) 
               
               
                 1-670 
                 3.35 (2H, tdd), 5.17 (2H, s), 6.02 
                 m/z = 379 
               
               
                   
                 (1H, tt), 6.23 (2H, m), 7.22 (1H, 
                 (M + H) 
               
               
                   
                 m), 7.33 (2H, m), 7.69 (1H, dd), 
               
               
                   
                 8.37 (1H, d) 
               
               
                 157-2 
                 5.51 (2H, s), 6.63 (1H, dd), 7.42 
                 m/z = 332 
               
               
                   
                 (1H, d), 7.77 (1H, d), 7.84 (1H, 
                 (M + H) 
               
               
                   
                 dd), 8.26 (1H, d), 8.45 (1H, d) 
               
               
                 1-10 
                 1.61 (1H, m), 2.29 (2H, m), 4.73 
                 m/z = 324 
               
               
                   
                 (2H, s), 7.26 (1H, m), 7.31 (1H, m), 
                 (M + H) 
               
               
                   
                 7.69 (1H, m), 7.79 (1H, m), 8.23 
               
               
                   
                 (1H, d), 8.40 (1H, d), 8.57 (1H, d) 
               
               
                 580-2 
                 5.47 (2H, s), 6.89 (1H, m), 7.47 
                 m/z = 332 
               
               
                   
                 (2H, m), 7.82 (2H, m), 8.41 (1H, s), 
                 (M + H) 
               
               
                   
                 8.56 (1H, d) 
               
               
                 1-671 
                 0.87 (3H, t), 1.28 (10H, m), 1.55 
                 m/z = 427 
               
               
                   
                 (2H, m), 2.96 (2H, t), 5.14 (2H, s), 
                 (M + H) 
               
               
                   
                 6.13 (1H, t), 6.18 (1H, d), 7.13 
               
               
                   
                 (1H, m), 7.30 (2H, m), 7.71 (1H, 
               
               
                   
                 dd), 8.37 (1H, d) 
               
               
                 1-658 
                 0.87 (3H, t), 1.25 (26H, m), 1.55 
                 m/z = 539 
               
               
                   
                 (2H, m), 2.96 (2H, t), 5.14 (2H, s), 
                 (M + H) 
               
               
                   
                 6.11 (1H, t), 6.17 (1H, d), 7.13 
               
               
                   
                 (1H, m), 7.30 (2H, m), 7.70 (1H, 
               
               
                   
                 dd), 8.36 (1H, d) 
               
               
                 1-659 
                 0.87 (3H, t), 1.26 (18H, m), 1.53 
                 m/z = 483 
               
               
                   
                 (2H, m), 2.95 (2H, t), 5.14 (2H, s), 
                 (M + H) 
               
               
                   
                 6.12 (1H, t), 6.18 (1H, d), 7.13 
               
               
                   
                 (1H, m), 7.31 (2H, m), 7.71 (1H, 
               
               
                   
                 dd), 8.36 (1H, d) 
               
               
                 1-660 
                 0.74 (3H, t), 0.97 (3H, d), 1.42 
                 m/z = 371 
               
               
                   
                 (2H, m), 3.08 (1H, m), 5.12 (2H, 
                 (M + H) 
               
               
                   
                 dd), 6.09 (1H, t), 6.23 (1H, d), 
               
               
                   
                 7.11 (1H, m), 7.24 (1H, m), 7.30 
               
               
                   
                 (1H, d), 7.67 (1H, dd), 8.35 
               
               
                   
                 (1H, d) 
               
               
                 1-681 
                 0.77, 0.90 (6H, t × 2), 1.40 (4H, 
                 m/z = 385 
               
               
                   
                 m), 2.97 (1H, m), 5.11 (2H, s), 
                 (M + H) 
               
               
                   
                 6.10 (1H, t), 6.25 (1H, d), 7.11 
               
               
                   
                 (1H, m), 7.24 (1H, d), 7.32 (1H, 
               
               
                   
                 d), 7.66 (1H, dd), 8.34 (1H, d) 
               
               
                 1-686 
                 0.81, 0.91 (6H, t × 2), 1.02-1.45 
                 m/z = 413 
               
               
                   
                 (8H, m), 3.19 (1H, m), 5.12 (2H, 
                 (M + H) 
               
               
                   
                 s), 6.10 (1H, t), 6.25 (1H, d), 
               
               
                   
                 7.11 (1H, m), 7.22 (1H, d), 7.30 
               
               
                   
                 (1H, d), 7.64 (1H, dd), 8.33 
               
               
                   
                 (1H, d) 
               
               
                 1-661 
                 0.81 (3H, t), 0.97 (3H, d), 
                 m/z = 385 
               
               
                   
                 0.90-1.50 (4H, m), 3.19 (1H, m), 
                 (M + H) 
               
               
                   
                 5.07 (1H, d), 5.15 (1H, d), 6.09 
               
               
                   
                 (1H, t), 6.24 (1H, d), 7.11 (1H, 
               
               
                   
                 m), 7.27 (2H, m), 7.66 (1H, dd), 
               
               
                   
                 8.34 (1H, d) 
               
               
                 1-662 
                 0.75 (3H, d), 0.80 (3H, d), 0.94 
                 m/z = 385 
               
               
                   
                 (3H, d), 1.61 (1H, m), 2.86 (1H, 
                 (M + H) 
               
               
                   
                 m), 5.11 (2H, s), 6.09 (1H, t), 
               
               
                   
                 6.23 (1H, d), 7.11 (1H, t), 7.25 
               
               
                   
                 (1H, d), 7.30 (1H, d), 7.66 (1H, 
               
               
                   
                 dd), 8.34 (1H, d) 
               
               
                 1-663 
                 1.35 (3H, d), 4.33 (1H, q), 5.05 
                 m/z = 419 
               
               
                   
                 (1H, d), 5.11 (1H, d), 6.00 (1H, 
                 (M + H) 
               
               
                   
                 d), 6.08 (1H, t), 6.96 (1H, m), 
               
               
                   
                 7.15-7.26 (7H, m), 7.63 (1H, 
               
               
                   
                 dd), 8.33 (1H, d) 
               
               
                 1-664 
                 1.55-1.75 (3H, m), 1.95 (1H, m), 
                 m/z = 445 
               
               
                   
                 2.70-2.88 (2H, m), 4.36 (1H, t), 
                 (M + H) 
               
               
                   
                 5.05 (1H, d), 5.20 (1H, d), 6.13 
               
               
                   
                 (1H, t), 6.38 (1H, d), 6.96 (1H, 
               
               
                   
                 m), 7.02-7.20 (5H, m), 7.28 (1H, 
               
               
                   
                 d), 7.62 (1H, dd), 8.3 (1H, d) 
               
               
                 1-665 
                 1.57 (3H, d), 4.78 (1H, d), 4.91 
                 m/z = 469 
               
               
                   
                 (1H, d), 5.18 (1H, q), 5.80 (1H, 
                 (M + H) 
               
               
                   
                 d), 5.93 (1H, t), 6.72 (1H, m), 
               
               
                   
                 7.05 (1H, d), 7.14 (1H, d), 7.38 
               
               
                   
                 (3H, m), 7.54 (1H, dd), 7.62 
               
               
                   
                 (1H, d), 7.66 (1H, d), 7.80 (1H, 
               
               
                   
                 d), 7.84 (1H, d), 8.28 (1H, d) 
               
               
                 1-666 
                 0.74 (3H, t), 1.75 (2H, m), 4.03 
                 m/z = 433 
               
               
                   
                 (1H, t), 5.06 (2H, dd), 5.85 
                 (M + H) 
               
               
                   
                 (1H, d), 6.05 (1H, m), 6.86 (1H, 
               
               
                   
                 m), 7.10-7.28 (7H, m), 7.63 (1H, 
               
               
                   
                 dd), 8.33 (1H, d) 
               
               
                 1-667 
                 1.34 (3H, d), 4.45 (1H, q), 5.11 
                 m/z = 409 
               
               
                   
                 (1H, d), 5.16 (1H, d), 6.07 (1H, 
                 (M + H) 
               
               
                   
                 m), 6.14 (1H, td), 6.26 (2H, m), 
               
               
                   
                 7.11 (1H, m), 7.28 (3H, m), 7.67 
               
               
                   
                 (1H, dd), 8.36 (1H, d) 
               
               
                 1-676 
                 5.06 (2H, s), 5.37 (1H, s), 5.38 
                 m/z = 481 
               
               
                   
                 (1H, d), 6.07 (1H, t), 6.85 (1H, 
                 (M + H) 
               
               
                   
                 t), 7.10-7.28 (12H, m), 7.61 
               
               
                   
                 (1H, d), 8.33 (1H, s) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 53 
               
               
                   
               
               
                 Compound 
                   
                 MS or IR 
               
               
                 No. 
                 1H-NMR (CDCl3, δ, ppm) 
                 (KBr, v, cm −1 ) 
               
               
                   
               
             
            
               
                 1-668 
                 0.79 (9H, s), 0.85 (3H, d), 2.89 
                 m/z = 399 
               
               
                   
                 (1H, q), 5.11 (2H, s), 6.08 (1H, 
                 (M + H) 
               
               
                   
                 t), 6.23 (1H, d), 7.10 (1H, t), 
               
               
                   
                 7.23 (1H, d), 7.30 (1H, d), 7.65 
               
               
                   
                 (1H, d), 8.34 (1H, s) 
               
               
                 47-2 
                 5.68 (2H, d), 6.57 (1H, m), 7.34 
                 m/z = 334 
               
               
                   
                 (1H, d), 7.80 (1H, m), 7.97 (1H, 
                 (M + H) 
               
               
                   
                 dd), 8.39 (1H, d), 8.57 (1H, s) 
               
               
                 91-2 
                 5.92 (2H, s), 6.95 (1H, d), 7.30 
                 m/z = 350 
               
               
                   
                 (1H, d), 7.69 (1H, m), 7.86 (1H, 
                 (M + H) 
               
               
                   
                 dd), 8..49 (1H, dd), 8.53 (1H, d) 
               
               
                 478-2 
                 2.59 (3H, s), 5.77 (2H, s), 6.75 
                 m/z = 330 
               
               
                   
                 (1H, d), 7.31 (1H, d), 7.63 (1H, 
                 (M + H) 
               
               
                   
                 dd), 7.72 (1H, m), 8.33 (1H, d), 
               
               
                   
                 8.45 (1H, d) 
               
               
                 479-2 
                 2.73 (3H, s), 5.71 (2H, s), 6.73 
                 m/z = 336 
               
               
                   
                 (1H, d), 7.63 (1H, s), 7.69 (1H, 
                 (M + H) 
               
               
                   
                 t), 8.44 (1H, d) 
               
               
                 1-51 
                 1.60 (2H, m), 1.73 (1H, m), 2.03 
                 m/z = 369 
               
               
                   
                 (4H, m), 3.75 (1H, m), 5.12 (2H, 
                 (M + H) 
               
               
                   
                 s), 6.12 (1H, t), 6.16 (1H, d), 
               
               
                   
                 7.10 (1H, m), 7.25 (1H, d), 7.32 
               
               
                   
                 (1H, d), 7.71 (1H, dd), 8.37 
               
               
                   
                 (1H, d) 
               
               
                 566-2 
                 4.09 (3H, s), 5.71 (2H, s), 6.25 
                 m/z = 346 
               
               
                   
                 (1H, d), 7.29 (1H, d), 7.74 (1H, 
                 (M + H) 
               
               
                   
                 t), 7.97 (1H, dd), 8.17 (1H, d), 
               
               
                   
                 8.50 (1H, d) 
               
               
                 488-2 
                 1.77 (1H, m), 2.11 (1H, m), 2.62 
                 m/z = 289 
               
               
                   
                 (3H, s), 2.98 (1H, m), 3.53 (1H, 
                 (M + H) 
               
               
                   
                 dd), 3.67 (1H, dd), 3.78 (1H, 
               
               
                   
                 m), 3.98 (1H, m), 4.22 (1H, m), 
               
               
                   
                 4.65 (1H, m), 6.73 (1H, d), 7.66 
               
               
                   
                 (1H, t), 8.32 (1H, d) 
               
               
                 511-2 
                 5.58 (2H, s), 7.38 (1H, d), 7.86 
                 m/z = 361 
               
               
                   
                 (1H, dd), 8.40 (1H, dd), 8.47 
                 (M + H) 
               
               
                   
                 (1H, d), 8.55 (1H, d), 8.93 (1H, d) 
               
               
                 1-669 
                 1.42 (3H, d), 4.65 (1H, q), 5.12 
                 m/z = 425 
               
               
                   
                 (2H, s), 6.13 (2H, m), 6.75 (1H, 
                 (M + H) 
               
               
                   
                 d), 6.88 (1H, dd), 7.07 (1H, m), 
               
               
                   
                 7.11 (1H, d), 7.26 (2H, m), 7.65 
               
               
                   
                 (1H, dd), 8.35 (1H, d) 
               
               
                 179-2 
                 5.30 (2H, s), 6.43 (1H, dd), 
                 m/z = 332 
               
               
                   
                 6.66 (1H, dd), 7.40 (1H, d), 
                 (M + H) 
               
               
                   
                 7.60 (2H, m), 8.20 (1H, d) 
               
               
                 555-2 
                 3.87 (3H, s), 5.60 (2H, s), 7.51 
                 m/z = 346 
               
               
                   
                 (1H, d), 7.88 (1H, dd), 7.93 
                 (M + H) 
               
               
                   
                 (1H, dd), 8.34 (1H, d), 8.49 
               
               
                   
                 (1H, d), 8.56 (1H, d) (DMSO-d6) 
               
               
                 577-2 
                 5.65 (2H, s), 6.87 (1H, td), 
                 m/z = 349 
               
               
                   
                 7.30 (1H, d), 7.81 (1H, m), 8.08 
                 (M + H) 
               
               
                   
                 (1H, dd), 8.13 (1H, d), 8.54 
               
               
                   
                 (1H, d) 
               
               
                 544-2 
                 3.93 (3H, s), 5.45 (2H, s), 6.49 
                 m/z = 346 
               
               
                   
                 (1H, dd), 7.31 (1H, d), 7.66 
                 (M + H) 
               
               
                   
                 (1H, d), 7.83 (1H, dd), 8.13 
               
               
                   
                 (1H, d), 8.42 (1H, d) 
               
               
                 168-2 
                 5.62 (2H, s), 7.43 (1H, d), 7.64 
                 m/z = 332 
               
               
                   
                 (1H, dd), 7.88 (1H, dd), 7.94 
                 (M + H) 
               
               
                   
                 (1H, d), 8.26 (1H, d), 8.49 (1H, d) 
               
               
                 1-644 
                 4.18 (2H, s), 4.68 (2H, s), 
                 m/z = 368 
               
               
                   
                 5.36 (2H, s), 6.55 (1H, m), 
                 (M + H) 
               
               
                   
                 7.16 (1H, d), 7.29 (1H, d), 
               
               
                   
                 7.35 (2H, m), 7.40 (2H, m), 
               
               
                   
                 1.52 (2H, m), 7.75 (1H, dd), 
               
               
                   
                 8.28 (1H, d), 8.40 (1H, d) 
               
               
                 578-644 
                 4.19 (2H, s), 4.69 (2H, s), 
                 m/z = 334 
               
               
                   
                 5.42 (2H, s), 6.52 (1H, m), 
                 (M + H) 
               
               
                   
                 7.20 (1H, m), 7.30 (1H, m), 
               
               
                   
                 7.32 (2H, m), 7.40 (2H, m), 
               
               
                   
                 7.55 (2H, m), 7.72 (1H, dd), 
               
               
                   
                 8.30 (1H, dd), 8.52 (1H, dd), 
               
               
                   
                 8.62 (1H, d) 
               
               
                 1-703 
                 5.20 (1H, d), 5.45 (1H, d), 
                 1715, 1636, 
               
               
                   
                 6.55 (1H, m) 7.34 (1H, m), 
                 1552, 1505, 
               
               
                   
                 7.50 (1H, m), 7.60 (1H, m), 
                 1457, 1174, 
               
               
                   
                 7.79 (1H, dd), 8.39 (1H, d) 
                 1144 
               
               
                 1-707 
                 5.43 (2H, s), 6.93 (1H, m), 
                 (EI-HRMS) 
               
               
                   
                 7.36 (1H, d), 7.77-7.85 (3H, 
                 m/z = 351.0084 
               
               
                   
                 m), 7.95 (1H, dd), 8.39 (1H, d) 
                 (M+) 
               
               
                 1-706 
                 1.20 (6H, m), 2.67 (4H, m), 
                 m/z = 298 
               
               
                   
                 5.22 (2H, s), 6.52 (1H, m),. 
                 (M + H) 
               
               
                   
                 7.31 (1H, m), 7.51 (1H, m), 
               
               
                   
                 7.60 (1H, dd), 7.73 (1H, m), 
               
               
                   
                 7.84 (1H, d), 8.41 (1H, d) 
               
               
                 1-692 
                 1.11 (3H, t), 1.20 (3H, t), 3.76 
                 m/z = 356 
               
               
                   
                 (2H, m), 3.92 (2H, m), 6.58 (1H, 
                 (M + H) 
               
               
                   
                 m), 7.26 (1H, d)., 7.53 (2H, m), 
               
               
                   
                 7.74 (1H, dd), 8.12 (1H, d), 8.40 
               
               
                   
                 (1H, d) (DMSO-d6) 
               
               
                 1-700 
                 1.20 (6H, m), 2.67 (4H, m), 5.22 
                 m/z = 404 
               
               
                   
                 (2H, s), 6.52 (1H, m),. 7.31 (1H, 
                 (M + H) 
               
               
                   
                 m), 7.51 (1H, m), 7.60 (1H, dd), 
               
               
                   
                 7.73 (1H, m), 7.84 (1H, d), 8.41 
               
               
                   
                 (1H, d) 
               
               
                 1-701 
                 0.95 (6H, m), 1.56 (4H, m), 2.62 
                 m/z = 432 
               
               
                   
                 (4H, m), 5.18 (2H, s), 6.52 (1H, 
                 (M + H) 
               
               
                   
                 m), 7.34 (1H, m), 7.49 (1H, m), 
               
               
                   
                 7.59 (1H, m), 7.77 (1H, dd), 7.84 
               
               
                   
                 (1H, d), 8.42 (1H, d) 
               
               
                 1-702 
                 1.13-1.46 (m, 12H), 3.20 (m, 2H), 
                 m/z = 432 
               
               
                   
                 5.27 (s, 2H), 6.51 (m, 1H), 7.31 
                 (M + H) 
               
               
                   
                 (m, 1H), 7.52 (m, 1H), 7.63 (m, 
               
               
                   
                 1H), 7.78 (m, 2H), 8.43 (d, 1H) 
               
               
                 1-646 
                 1.31 (6H, d), 4.95 (1H, sep), 
                 1646, 1620, 
               
               
                   
                 5.40 (2H, s), 6.40 (1H, m), 7.28 
                 1548, 1504, 
               
               
                   
                 (1H, d), 7.40 (2H, m), 7.73 (1H, 
                 1453, 
               
               
                   
                 dd) 8.05 (1H, m), 8.40 (1H, d) 
               
               
                 1-645 
                 5.18 (2H, s), 5.37 (2H, s), 6.43 
                 1655, 1518, 
               
               
                   
                 (1H, m), 7.25-7.36 (4H, m), 
                 1455, 1399, 
               
               
                   
                 7.41-7.46 (4H, m), 7.72 (1H, 
                 1235 
               
               
                   
                 dd), 8.12 (1H, m), 8.38 (1H, d) 
               
               
                 1-643 
                 5.52 (2H, s), 6.78 (1H, m), 7.31 
                 1633, 1601, 
               
               
                   
                 (1H, d), 7.68-7.75 (3H, m), 8.39 
                 1541, 1502, 
               
               
                   
                 (1H, m), 8.56 (1H, s) 
                 1482, 1453, 
               
               
                   
                   
                 1384 
               
               
                 2-643 
                 5.51 (2H, s), 6.80 (1H, m), 7.60 
                 1632, 1597, 
               
               
                   
                 (1H, s), 7.75 (2H, m), 8.57 (1H, m) 
                 1541, 1506, 
               
               
                   
                   
                 1483, 1455, 
               
               
                   
                   
                 1388 
               
               
                   
               
            
           
         
       
     
     Synthetic Example of Comparative Compound 
     Comparative Example 1 
     N-[1-chloropyridine-3-yl]methyl)pyridine-2(1H)-ylidene]cyanamide (Patent Document 5, Compound 20) 
     
       
         
         
             
             
         
       
     
     128 mg (0.58 mmol) of the 1-[(6-chloropyridin-3-yl)methyl]pyridine-2(1H)-imine obtained by the above-described method was dissolved in 5 ml of anhydrous DMF, 40 mg (net 24 mg, 1.04 mmol) of NaH (oil phase, purity 60%) was added thereto, and the resulting mixture was stirred at room temperature for 30 minutes. 60 mg (0.57 mmol) of cyanogen bromide was added thereto and the resulting mixture was stirred overnight. After the reaction was completed, water and ethyl acetate were added to the reaction solution to perform liquid separation. The organic layer was dried over anhydrous magnesium sulfate, then concentrated under reduced pressure and purified by a TLC plate (one sheet of 0.5 mm plate, evolved with 100% ethyl acetate) to obtain the subject material. Amount obtained 14 mg (yield 10%). 
       1 N-NMR (CDCl 3 , δ, ppm): 5.28 (2H, s), 6.55 (1H, m), 7.33 (2H, m), 7.56 (2H, m), 7.75 (1H, dd), 8.40 (1H, d) 
     Comparative Example 2 
     N-[1-((6-chloropyridine-3-yl)methyl)pyridine-2(2H)-ylidene]acetamide (Patent Document 3, Compound 2) 
     
       
         
         
             
             
         
       
     
     20 ml of anhydrous dichloromethane was added to 118 mg (0.46 mmol) the 1-[(6-[chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride obtained by the above-described method, 159 μl (1.16 mmol, 116 mg) of triethylamine and 33 μl of acetyl chloride were added thereto, and the resulting mixture was stirred at room temperature for 15 minutes. Water was added to the reaction solution to stop the reaction and liquid separation was performed with chloroform and water. The organic layer was washed with a saturated ammonium chloride aqueous solution and then concentrated, hexane was added thereto to precipitate a solid, and thus the solid was collected, washed and subjected to bath drying to obtain the subject material. Amount obtained 21 mg (yield 17%). 
       1 N-NMR (CDCl 3 , δ, ppm): 2.21 (3H, s), 5.35 (2H, s), 6.46 (1H, m), 7.32 (1H, d), 7.48 (2H, m), 7.75 (1H, d), 8.10 (1H, dd), 8.45 (1H, dd) 
     MS:m/z=322 (M+H) 
     Comparative Example 3 
     3-[1-((6-chloropyridine-3-yl)methyl)imidazolidine-2-ylidene]-1,1,1-trifluoropropane-2-on (Patent Document 2, Example 4) 
     
       
         
         
             
             
         
       
     
     20 ml of ethylenediamine was added to 2.0 g (12.4 mmol) of 2-chloro-5-chloromethylpyridine, and the resulting mixture was stirred overnight. After the reaction was completed, the mixture was concentrated under reduced pressure and acetonitrile was added thereto to filter off insoluble materials. The mixture was concentrated under reduced pressure to obtain 2.45 g (yield: 100%) of N-((6-chloropyridin-3-yl)methyl)ethane-1,2-diamine. 
     77 mg (0.42 mmol) of the N-((6-chloropyridin-3-yl)methyl)ethan-1,2-diamine obtained by the aforementioned method was dissolved in 8 ml of anhydrous acetonitrile, the resulting solution was added to 60 mg (0.28 mmol) of the 1,1,1-trifluoro-4,4-bis(methylthio)-3-butylen-2-one obtained by the above-described method, and the resulting mixture was heated and refluxed for 40 minutes. After the reaction was completed, the reaction solution was returned to room temperature and concentrated under reduced pressure, and ethyl acetate and water were added thereto to perform liquid separation. The organic layer was washed with anhydrous magnesium sulfate, concentrated under reduced pressure, and purified by silica gel column chromatography (hexane:ethyl acetate=3:1) to obtain the subject material. Amount obtained 59 mg (yield 69%). 
       1 N-NMR (CDCl 3 , δ, ppm): 3.49 (2H, t), 3.78 (2H, t), 4.40 (2H, s), 5.13 (1H, s), 7.37 (1H, d), 7.56 (1H, dd), 8.31 (1H, d), 9.34 (1H, br s) 
     m/z=306 (M+H) 
     Comparative Example 4 
     3-[3-((6-chloropyridine-3-yl)methyl)thiazoline-2-ylidene]-1,1,1-trifluoropropane-2-on (Patent Document 2, Example 3) 
     
       
         
         
             
             
         
       
     
     15 ml of anhydrous DMF was added to 1.30 g (33.9 mmol, 780 mg) of NaH (oil phase, purity 60%) and the resulting mixture was cooled to 0° C. 1.52 ml (1.90 g, 17.0 mmol) of 1,1,1-trifluoroacetone was added dropwise thereto, and the resulting mixture was stirred at 0° C. for 10 minutes. 7.0 ml (110 mmol, 8.35 g) of carbon disulfide was added thereto and the resulting mixture was stirred at 5° C. for 1 hour. Subsequently, the reaction solution was cooled to 0° C., 2.1 ml (34.0 mmol, 4.81 g) of methyl iodide was added thereto, and the resulting mixture was stirred at room temperature overnight. After the reaction was completed, the reaction solution was injected into iced water, and the mixture was stirred until the ice was completely melted. The mixture was transferred to a separatory funnel and extracted with ethyl acetate, and the organic layer was washed with a saturated saline solution, then dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The organic layer was purified by silica gel column chromatography (hexane:ethyl acetate=95:5) and a fraction including the subject material was collected and concentrated under reduced pressure. Hexane was added thereto to precipitate a solid, and thus the solid was collected, washed with hexane and then dried well to obtain 460 mg of 1,1,1-trifluoro-4,4-bis(methylthio)-3-butene-2-one (yield 13%). 
       1 N-NMR (CDCl 3 , δ, ppm): 2.56 (3H, s), 2.58 (2H, s), 6.25 (1H, s) 
     36 mg (0.46 mmol) of 2-aminoethanethiol dissolved in 10 ml of ethanol was added to 100 mg (0.46 mmol) of the 1,1,1-trifluoro-4,4-bis(methylthio)-3-butene-2-one obtained by the aforementioned method, and the resulting mixture was heated and refluxed for 6 hours, and stirred at room temperature for 13 hours. After the reaction was completed, ethanol was distilled off under reduced pressure, and the mixture was dissolved in ethyl acetate and washed once with water. The mixture was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure to obtain 73 mg (yield 81%) of 1,1,1-trifluoro-3-(thiazolidin-2-ylidene)propan-2-one. 
       1 N-NMR (CDCl 3 , δ, ppm): 3.35 (2H, m), 4.02 (2H, m), 5.61 (1H, s), 10.40 (1H, br s) 
     80 mg (0.50 mmol) of 2-chloro-5-chloromethylpyridine dissolved in 8 ml of anhydrous acetonitrile and 69 mg (0.50 mmol) of potassium carbonate were added to 65 mg (0.33 mmol) of the 1,1,1-trifluoro-3-(thiazolidin-2-ylidene)propan-2-one obtained by the aforementioned method, and the resulting mixture was heated and refluxed for 2 hours. After the reaction was completed, the reaction solution was returned to room temperature to filter off insoluble materials, and the filtrate was concentrated under reduced pressure. The filtrate was purified by silica gel column chromatography (hexane:ethyl acetate=1:1→1:3) to obtain the subject material. Amount obtained 53 mg (yield 50%) 
       1 N-NMR (CDCl 3 , δ, ppm): 3.20 (2H, t), 3.73 (2H, t), 4.61 (2H, s), 5.80 (1H, s), 7.36 (1H, d), 7.53 (1H, dd), 8.31 (1H, d) 
     MS: m/z=323 (M+H) 
     Comparative Example 5 
     3-[1-((6-chloropyridine-3-yl)methyl)imidazolidine-2-ylidene]-1,1,1,5,5,5-hexafluoropentane-2,4-dione (Patent Document 2, Example 5) 
     
       
         
         
             
             
         
       
     
     31 mg (0.10 mmol) of the 3-[1-((6-[chloropyridin-3-yl)methyl)imidazolidin-2-ylidene]-1,1,1-trifluoropropan-2-one obtained by the above-described method was dissolved in 2 ml of anhydrous dichloromethane, 20 μl (0.25 mmol, 20 mg) of pyridine and 28 μl (0.20 mmol, 42 mg) of trifluoroacetic anhydride were added in sequence, and the resulting mixture was stirred at room temperature for 30 minutes. The progress of the reaction was confirmed by TLC and the raw material was remaining, and thus 84 μl (0.60 mmol, 62 mg) of trifluoroacetic anhydride was added thereto and the resulting mixture was stirred at room temperature for 1 hour. After the reaction was completed, the reaction solution was concentrated under reduced pressure and purified by a TLC plate (one sheet of 0.5 mm plate, evolved with hexane:ethyl acetate=2:8) to obtain the subject material. Amount obtained 30 mg (yield 75%). 
       1 N-NMR (CD 3 OD, 6, ppm): 3.87 (4H, m), 4.51 (2H, s), 7.50 (1H, d), 7.82 (1H, dd), 8.35 (1H, d) 
     MS: m/z=402 (M+H) 
     Comparative Example 6 
     N-[1-((6-chloropyridine-3-yl)methyl)imidazolidine-2-ylidene]-2,2,2-trifluoroacetamide (Patent Document 2, Example 7) 
     
       
         
         
             
             
         
       
     
     4.61 g (2.49 mmol) of N-((6-chloropyridin-3-yl)methyl)ethane-1,2-diamine was synthesized by the above-described method. The compound was dissolved in 40 ml of anhydrous acetonitrile, 4.60 g (21.3 mmol) of the dimethyl(2,2,2-trifluoroacetyl)carbonimidedithioate obtained by the above-described method was added thereto, and the resulting mixture was heated and refluxed for 90 minutes. After the reaction was completed, the reaction solution was returned to room temperature, the solvent was distilled off under reduced pressure, and the precipitated solid was collected and washed with a small amount of acetonitrile to obtain the subject material. Amount obtained 2.17 g (yield 33%). 
       1 N-NMR (CDCl 3 , δ, ppm): 3.50 (2H, m), 3.76 (2H, m), 4.60 (2H, s), 7.34 (1H, d) 7.70 (1H, dd) 8.33 (1H, d) 
     Melting Point: 168-170° C. 
     Comparative Example 7 
     N-[3-((6-chloropyridine-3-yl)methyl)thiazoline-2-ylidene]-2,2,2-trifluoroacetamide (Patent Document 2, Example 6) 
     
       
         
         
             
             
         
       
     
     20 ml of ethanol was added to 77 mg (1.0 mmol) of 2-aminoethanethiol, 216 mmol (1.0 mmol) of the dimethyl(2,2,2-trifluoroacetyl)carbonimidedithioate synthesized by the above-described method was added thereto, and the resulting mixture was stirred at room temperature overnight. After the reaction was completed, the solvent was distilled off under reduced pressure and purified by silica gel column chromatography (hexane:ethyl acetate=1:1) to obtain 100 mg (yield 51%) of 2,2,2-trifluoro-N-(thiazolidin-2-ylidene)acetamide. The reaction was performed again by the same synthetic method, and 2,2,2-trifluoro-N-(thiazolidin-2-ylidene)acetamide was put together to obtain 350 mg of the compound. 
     2 ml of DMF and 18 ml of THF were added to 162 mg (0.82 mmol) of the 2,2,2-trifluoro-N-(thiazolidin-2-ylidene)acetamide obtained by the above-described method, 150 mg (1.09 mmol) of potassium carbonate was added thereto, and the resulting mixture was heated and refluxed for 20 hours. After the reaction was completed, the reaction solution was returned to room temperature to filter insoluble materials, and the filtrate was concentrated under reduced pressure. The filtrate was purified by TLC plates (two sheets of 0.5 mm plates, evolved with 100% ethyl acetate) to obtain the subject material. Amount obtained 230 mg (yield 87%). 
       1 N-NMR (CDCl 3 , δ, ppm): 3.27 (2H, m), 3.73 (2H, m), 4.86 (2H, s), 7.36 (1H, d) 7.72 (1H, dd) 8.36 (1H, d) 
     Melting Point: 96C 
     Comparative Example 8 
     1-[1-((6-chloropyridine-3-yl)methyl)pyridine-2(1H)-ylidene]-3-ethylthiourea (Patent Document 3, Japanese Patent Application Laid-Open No. 5-78323, Table 1, Compound No. 51) 
     
       
         
         
             
             
         
       
     
     10 ml of acetonitrile was added to 200 mg (0.78 mmol) of 1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride synthesized by the method described in Synthetic Example 3, 118 μl (0.86 mmol) of triethylamine and 68 μl (0.78 mmol) of ethyl isothiocyanate were added thereto in sequence, and the resulting mixture was heated and refluxed for 11 hours. After the reaction was completed, the reaction solution was returned to room temperature and concentrated under reduced pressure, and liquid separation was performed with ethyl acetate and a 1% hydrochloric acid aqueous solution. A saturated sodium bicarbonate water was added to the water layer to make the layer basic, and the layer was extracted once with ethyl acetate. The layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure to obtain a subject compound. Amount obtained 120 mg (yield 56%). 
     1H-NMR (CDCl3, δ, ppm): 1.06, 1.23 (3H, t×2), 3.21, 3.71 (2H, m×2), 5.23, 5.32 (2H, s×2), 6.25, 6.42 (1H, br s×2), 6.37, 6.51 (1H, m×2), 7.31-7.37 (2H, m), 7.47 (1H, m), 7.62 (1H, m), 8.14-8.22 (1H, m), 8.35 (1H, m) 
     MS: m/z=307 (M+H) 
     Melting point: 162-164° C. 
     Comparative Example 9 
     1-[1-((6-chloropyridine-3-yl)methyl)pyridine-2(1H)-ylidene]-3-ethoxycarbonylthiourea (Patent Document 3, Japanese Patent Application Laid-Open No. 5-78323, Table 1, Compound No. 56) 
     
       
         
         
             
             
         
       
     
     10 ml of acetonitrile was added to 200 mg (0.78 mmol) of 1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride synthesized by the method described in Synthetic Example 3, 118 μl (0.86 mmol) of triethylamine and 96 μl (0.82 mmol) of ethoxycarbonyl isothiocyanate were added thereto, and the resulting mixture was heated and refluxed for 1 hour. After the reaction was completed, the reaction solution was returned to room temperature and concentrated under reduced pressure, and liquid separation was performed with ethyl acetate and a saturated sodium bicarbonate water. The organic layer was washed once with water, then dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain the subject material. Amount obtained 156 mg (yield 57%). 17 mg of the subject material obtained by purifying 30 mg of the subject material with a TLC plate (one sheet of 0.5 mm plate, evolved twice with hexane:ethyl acetate=1:3) was provided for the measurement of spectrum data and the biological test. 
     1H-NMR (CDCl3, δ, ppm): 1.27 (3H, t), 4.16 (2H, q), 5.52 (2H, s), 6.82 (1H, td), 8.34 (1H, d), 7.72 (2H, m), 7.94 (2H, m), 8.34 (1H, d), 8.46 (1H, d) 
     MS:m/z=351 (M+H) 
     Melting point: 141-143° C. 
     Preparation Example 
     Preparation Example 1 [Granules] 
       
     
       
         
           
               
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Compound 1-20 
                 5% 
                 by weight 
               
               
                   
                 Bentonite 
                 40% 
                 by weight 
               
               
                   
                 Talc 
                 10% 
                 by weight 
               
               
                   
                 Clay 
                 43% 
                 by weight 
               
               
                   
                 Calcium ligninsulfonate 
                 2% 
                 by weight 
               
               
                   
                   
               
            
           
         
       
     
     The ingredients were homogeneously ground and mixed, water was added thereto to knead the ingredients thoroughly, and then the mixture was granulated and dried to obtain granules. 
     Preparation Example 2 [Granules] 
       
     
       
         
           
               
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Compound 3-3 
                 2% 
                 by weight 
               
               
                   
                 SAN X(R) P-252 
                 5% 
                 by weight 
               
               
                   
                 Binder 
                 1.5% 
                 by weight 
               
               
                   
                 Granular improving agent 
                 0.5% 
                 by weight 
               
               
                   
                 Clay 
                 91% 
                 by weight 
               
               
                   
                   
               
            
           
         
       
     
     The ingredients were homogeneously ground and mixed, water was added thereto to knead the ingredients thoroughly, and then the mixture was granulated and dried to obtain granules. 
     Preparation Example 3 [Wettable Powder] 
       
     
       
         
           
               
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Compound 1-42 
                 30% 
                 by weight 
               
               
                   
                 Clay 
                 50% 
                 by weight 
               
               
                   
                 White carbon 
                 2% 
                 by weight 
               
               
                   
                 Diatomaceous earth 
                 13% 
                 by weight 
               
               
                   
                 Calcium ligninsulfonate 
                 4% 
                 by weight 
               
               
                   
                 Sodium lauryl sulfate 
                 1% 
                 by weight 
               
               
                   
                   
               
            
           
         
       
     
     The ingredients were homogeneously mixed and ground to obtain wettable powder. 
     Preparation Example 4 [Water Dispersible Granule] 
       
     
       
         
           
               
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Compound 1-499 
                 30% 
                 by weight 
               
               
                   
                 Clay 
                 60% 
                 by weight 
               
               
                   
                 Dextrin 
                 5% 
                 by weight 
               
               
                   
                 Alkyl maleate copolymer 
                 4% 
                 by weight 
               
               
                   
                 Sodium lauryl sulfate 
                 1% 
                 by weight 
               
               
                   
                   
               
            
           
         
       
     
     The ingredients were homogeneously ground and mixed, water was added thereto to knead the ingredients thoroughly, and then the mixture was granulated and dried to obtain water dispersible granules. 
     Preparation Example 5 [Flowables] 
       
     
       
         
           
               
               
               
             
               
                   
               
             
            
               
                 Compound 1-21 
                 25% 
                 by weight 
               
               
                 POE polystyrylphenyl ether sulfate 
                 5% 
                 by weight 
               
               
                 Propylene glycol 
                 6% 
                 by weight 
               
               
                 Bentonite 
                 1% 
                 by weight 
               
               
                 1% xanthan-gum aqueous solution 
                 3% 
                 by weight 
               
               
                 PRONALEX-300 (TOHO Chemical Industry Co., 
                 0.05% 
                 by weight 
               
               
                 Ltd.) 
               
               
                 ADDAC827 (KI Chemical Industry Co., Ltd.) 
                 0.02% 
                 by weight 
               
            
           
           
               
               
            
               
                 Water 
                 added to 100% 
               
               
                   
                 by weight 
               
               
                   
               
            
           
         
       
     
     All the ingredients except for the 1% xanthan gum aqueous solution and a suitable amount of water were premixed together from the blending, and the mixture was then ground by a wet grinder. Thereafter, the 1% xanthan gum aqueous solution and the remaining water were added thereto to obtain 100% by weight of flowables. 
     Preparation Example 6 [Emulsifiable Concentrate] 
       
     
       
         
           
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Compound 212-2 
                 15% by weight 
               
               
                   
                 N,N-dimethylformamide 
                 20% by weight 
               
               
                   
                 Solvesso 150 (Exxon Mobil Corporation) 
                 55% by weight 
               
               
                   
                 Polyoxyethylene alkyl aryl ether 
                 10% by weight 
               
               
                   
                   
               
            
           
         
       
     
     The ingredients were homogeneously mixed and dissolved to obtain an emulsifiable concentrate. 
     Preparation Example 7 [Dust] 
       
     
       
         
           
               
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Compound 1-20 
                 2% 
                 by weight 
               
               
                   
                 Clay 
                 60% 
                 by weight 
               
               
                   
                 Talc 
                 37% 
                 by weight 
               
               
                   
                 Calcium stearate 
                 1% 
                 by weight 
               
               
                   
                   
               
            
           
         
       
     
     The ingredients were homogeneously mixed to obtain dust. 
     Preparation Example 8 [DL Dust] 
       
     
       
         
           
               
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Compound 168-2 
                 2% 
                 by weight 
               
               
                   
                 DL clay 
                 94.5% 
                 by weight 
               
               
                   
                 White carbon 
                 2% 
                 by weight 
               
               
                   
                 Calcium Stearate 
                 1% 
                 by weight 
               
               
                   
                 Light liquid paraffin 
                 0.5% 
                 by weight 
               
               
                   
                   
               
            
           
         
       
     
     The ingredients were homogeneously mixed to obtain dust. 
     Preparation Example 9 [Microgranule Fine] 
       
     
       
         
           
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Compound 4-3 
                 2% by weight 
               
               
                   
                 Carrier 
                 94% by weight  
               
               
                   
                 White carbon 
                 2% by weight 
               
               
                   
                 Hisol SAS-296 
                 2% by weight 
               
               
                   
                   
               
            
           
         
       
     
     The ingredients were homogeneously mixed to obtain dust. 
     Preparation Example 10 [Liquid Drops] 
       
     
       
         
           
               
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Compound 1-20 
                 10% 
                 by weight 
               
               
                   
                 Benzyl alcohol 
                 74.9% 
                 by weight 
               
               
                   
                 Propylene carbonate 
                 15% 
                 by weight 
               
               
                   
                 BHT 
                 0.1% 
                 by weight 
               
               
                   
                   
               
            
           
         
       
     
     The ingredients were homogeneously stirred and dissolved to obtain liquid drops. 
     Preparation Example 11 [Liquid Drops] 
       
     
       
         
           
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Compound 253-2 
                 48% by weight 
               
               
                   
                 Ethanol 
                 52% by weight 
               
               
                   
                   
               
            
           
         
       
     
     The ingredients were homogeneously mixed to obtain liquid drops. 
     In addition, examples of a mixed composition of the compound of the present invention and other pest control agents will be described as follows. 
     Preparation Example 12 [Granules] 
       
     
       
         
           
               
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 Compound 1-20 
                 2% 
                 by weight 
               
               
                   
                 Probenazole 
                 24% 
                 by weight 
               
               
                   
                 Binder 
                 3.0% 
                 by weight 
               
               
                   
                 Guanular improving agent 
                 0.5% 
                 by weight 
               
               
                   
                 Clay 
                 70.5% 
                 by weight 
               
               
                   
                   
               
            
           
         
       
     
     The ingredients were homogeneously ground and mixed, water was added thereto to knead the ingredients thoroughly, and then the mixture was granulated and dried to obtain granules. 
     Test Example 
     Test Example 1  Plutella xylostella  Control Test 
     A leaf disk having a diameter of 5.0 cm was cut out from a cabbage in pot culture, and a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 50% acetone water (0.05% Tween20 available), was sprayed to the leaf disk. After an air drying process, second instar larvae were released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Three days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. Test in duplicate. 
       mortality larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     As a result, compounds 266-2, 224-2, 7-2, 1-21, 3-20, 4-20, 4-5, 1-501, 1-499, 1-511, 1-519, 1-523, 1-528, 1-531, 1-42, 1-500, 1-72, 1-150, 1-47, 1-55, 1-122, 1-124, 1-64, 1-52, 1-121, 1-53, 1-76, 1-670, 1-671, 1-658, 1-659, 1-660, 1-681, 1-686, 1-661, 479-2, and 179-2, exhibited insecticidal activity having a mortality of 80% or higher by a foliar treatment at 500 ppm. 
     Further, compounds 1-20, 1-21, 4-20, 3-3, 4-3, 5-5, 6-5, 1-22, 1-23, 5-20, 5-3, 6-3, 5-4, 4-4, 6-4, 4-5, 2-20, 3-4, 3-5, 1-501, 1-499, 1-511, 1-519, 1-523, 1-507, 1-516, 1-518, 1-527, 1-521, 1-43, 1-536, 1-42, 1-500, 1-534, 1-535, 1-72, 1-150, 1-67, 1-515, 1-56, 1-512, 1-514, 1-50, 1-114, 1-44, 1-118, 1-119, 1-122, 1-671, 1-658, 1-659, 1-663, 1-664, 1-665, 1-666 and 1-667 exhibited insecticidal activity having a mortality of 80% or higher by a foliar treatment at 100 ppm. 
     Meanwhile, Comparative Example 8 (Japanese Patent Application Laid-Open No. 5-78323, Compound No. 51 in Table 1) exhibited a mortality of 20% in the treatment at 500 ppm. 
     Test Example 2 Pest Control Test Against  Spodoptera litura    
     A leaf disk having a diameter of 5.0 cm was cut out from a cabbage in pot culture, and a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 50% acetone water (0.05% Tween20 available), was sprayed to the leaf disk. After an air drying process, third instar larvae were released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Three days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. Test in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     As a result, compounds 1-21, 3-20, 4-20, 4-5, 1-499, 1-43, 1-67, 1-44, 1-47 and 1-55 exhibited insecticidal activity having a mortality of 80% or higher by a foliar treatment at 500 ppm. Further, compounds 1-20, 5-5, 4-5, 1-671, 478-2 and 479-2 exhibited insecticidal activity having a mortality of 80% or higher by a foliar treatment at 100 ppm. 
     Meanwhile, Comparative Example 8 (Japanese Patent Application Laid-Open No. 5-78323, Compound No. 51 in Table 1) and Comparative Example 9 (the same Compound 56) exhibited a mortality of 10% and 11% in the treatment at 500 ppm, respectively. 
     Test Example 3 Pest Control Test of  Aphis gossypii    
     A leaf disk having a diameter of 2.0 cm was cut out from a cucumber in pot culture, and a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 50% acetone water (0.05% Tween20 available), was sprayed to the leaf disk. After an air drying process, first instar larvae were released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Three days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. Test in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     As a result, compounds 266-2, 444-2, 201-2, 212-2, 213-2, 1-17, 1-18, 1-19, 7-2, 1-13, 4-5, 11-20, 1-501, 1-499, 1-510, 1-511, 1-519, 1-523, 1-528, 1-531, 1-42, 1-500, 1-72, 1-150, 251-2, 13-2, 479-2, 566-2, 488-2, 511-2, 555-2, 577-2, 1-644, 578-644 and 1-646 exhibited insecticidal activity having a mortality of 80% or higher by a foliar treatment at 500 ppm. 
     Further, compounds 266-2, 444-2, 190-2, 201-2, 224-2, 102-2, 212-2, 1-20, 213-2, 1-17, 1-18, 7-2, 1-13, 1-21, 3-20, 4-20, 4-5, 3-3, 2-20, 10-20, 3-4, 11-20, 1-14, 1-37, 1-40, 1-15, 1-35, 1-501, 1-499, 1-511, 1-519, 1-523, 1-531, 1-507, 1-516, 1-518, 1-521, 1-43, 1-42, 1-500, 1-72, 1-150, 1-67, 1-515, 1-56, 1-512, 1-514, 1-50, 1-114, 1-44, 1-118, 1-119, 1-47, 1-55, 1-50, 1-114, 1-44, 1-118, 1-119, 1-47, 1-55, 1-122, 1-124, 1-64, 1-52, 1-121, 1-53, 1-76, 1-670, 157-2, 1-10, 1-671, 1-658, 1-659, 1-660, 1-681, 1-686, 1-661, 478-2, 479-2, 566-2, 488-2, 511-2, 555-2, 577-2, 1-644, 578-644 and 1-646 exhibited insecticidal activity having a mortality of 80% or higher by a foliar treatment at 100 ppm. 
     Further, compounds 266-2, 190-2, 102-2, 1-20, 7-2, 1-13, 1-21, 3-20, 4-5, 3-3, 2-20, 3-4, 3-5, 1-14, 1-37, 1-501, 1-511, 1-507, 1-516, 1-518, 1-43, 1-72, 1-150, 1-67, 1-515, 1-56, 1-512, 1-514, 1-114, 1-118, 1-119, 1-50, 1-118, 1-119, 1-47, 1-122, 1-124, 1-64, 1-121, 1-53, 1-76, 1-670, 580-2, 1-671, 1-658, 1-659, 478-2, 479-2, 1-644, 578-644, 1-646, 1-663, 1-664, 1-665, 1-666 and 1-667 exhibited insecticidal activity having a mortality of 80% or higher by a foliar treatment at 20 ppm. 
     Test Example 4 Pest Control Test of  Aulacophora femoralis    
     A leaf disk having a diameter of 2.8 cm was cut out from a cucumber in pot culture, and a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 50% acetone water (0.05% Tween20 available), was sprayed to the leaf disk. After an air drying process, adults were released thereto. Thereafter, the adults were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Three days after the release, the adults were observed for survival or death, and the mortality of adults was calculated by the following equation. Test in duplicate. 
       Mortality of adults (%)={number of dead adults/(number of survived adults+number of dead adults)}×100
 
     As a result, compounds 1-20 and 4-20 exhibited insecticidal activity having a mortality of 80% or higher by a foliar treatment at 10 ppm. 
     Test Example 5 Pest Control Test Against  Callosobruchus chinensis    
     1 μL(/head) of a drug solution of the compound of the present invention prepared at a predetermined concentration with acetone was treated to the back of  Callosobruchus chinensis  adults. After the drug treatment, the adults were transferred to a plastic cup and left to stand in a thermostatic chamber at 25° C. Twenty four hours after the treatment, the adults were observed for survival or death, and the mortality of adults was calculated by the following equation. 
       Rate of agonized adults (%)={number of dead adults/(number of survived adults+number of dead adults)}×100
 
     As a result, compound 1-20 exhibited insecticidal activity having a mortality of 80% or higher in the rate at 0.1 μg/head. 
     Test Example 6 Pest Control Test of  Laodelphax striatella    
     A drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 50% acetone water (0.05% Tween20 available), was foliar sprayed to a rice seedling in pot culture. After an air drying process, second instar larvae were released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Six days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. Test in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     As a result, compounds 1-20, 1-42, 1-499, 1-519 and 4-20 exhibited insecticidal activity having a mortality of 80% or higher by a foliar treatment at 1.25 ppm. 
     Test Example 7 Pest Control Test of  Frankliniella occidentalis    
     A leaf disk having a diameter of 2.8 cm was cut out from a kidney bean in pot culture, and a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 50% acetone water (0.05% Tween20 available), was sprayed to the leaf disk. After an air drying process, first instar larvae were released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Three days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. Test in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     As a result, compounds 266-2, 224-2, 212-2, 1-20, 1-21, 3-20, 4-20, 1-15, 1-501, 1-499, 1-511, 1-72, 1-150, 1-56, 1-50, 1-114, 1-119, 1-47, 1-55, 1-50, 1-114, 1-119, 1-47, 1-55, 1-122, 1-124, 1-64, 1-52, 1-121, 1-53, 1-76, 1-670, 1-671, 1-660, 1-681, 1-686, 478-2, 479-2, 566-2 and 488-2 exhibited insecticidal activity having a mortality of 80% or higher by a foliar treatment at 500 ppm. 
     Further, compounds 212-2, 1-20, 1-21, 3-3, 4-3, 5-3, 6-3, 1-56, 1-121, 1-76, 479-2 and 488-2 exhibited insecticidal activity having a mortality of 80% or higher by a foliar treatment at 100 ppm. 
     Meanwhile, Comparative Example 8 (Japanese Patent Application Laid-Open No. 5-78323, Compound No. 51 in Table 1) exhibited a mortality of 15% in the treatment at 500 ppm. 
     Test Example 8 Pest Control Test of  Trigonotylus caelestialium    
     Wheat seedling leaves and stems four days after the dissemination of seedlings were dipped for 30 seconds in a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 50% acetone water (0.05% Tween20 available). After an air drying process, the wheat seedling leaves and stems were placed into a glass tube, and two second instar larvae of  Trigonotylus caelestialium  were released to the same glass tube. After the larvae were released, the tube was lidded to leave the larvae to stand in a thermostatic chamber at 25° C. In order to supply water to the wheat during the test, water was given to the wheat from the bottom of the glass tube. Three days after the treatment, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     As a result, compounds 102-2, 1-20, 1-13, 1-21, 3-20, 4-20, 4-5, 1-521, 1-150, 1-122, 1-124, 1-52, 1-121, 1-76 and 267-2 exhibited insecticidal activity having a mortality of 80% or higher by a dipping treatment of the drug solution at 50 ppm. 
     Further, compounds 102-2, 1-20, 1-21, 3-20, 4-20, 3-3, 4-3, 6-5, 1-22, 1-23, 6-3, 5-4, 4-4, 3-4 and 478-2 exhibited insecticidal activity having a mortality of 80% or higher by a dipping treatment of the drug solution at 10 ppm. 
     Test Example 9 Pest Control Test of  Laodelphax striatella    
     Wheat seedling roots forty eight hours after the dissemination of seeds were treated with a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 10% acetone water. The drug was absorbed from the roots for 72 hours, and then ten second instar larvae of  Laodelphax striatella  were each released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Seven days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. The test was performed in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     As a result, compounds 102-2, 1-20, 7-2, 1-13, 1-21, 3-20, 4-20, 5-4, 4-4, 6-4, 4-5, 3-3, 2-20, 3-4, 3-5, 1-501, 1-499, 1-511, 1-519, 1-523, 1-528, 1-531, 1-42, 1-500, 1-534, 1-535, 1-72, 1-150, 1-67, 1-515, 1-56, 1-512, 1-514, 1-47, 1-55, 1-122, 1-124, 1-64, 1-52, 1-121, 1-53, 1-76, 1-647, 1-670 and 478-2 exhibited high insecticidal activity having a mortality of 80% or higher in the rate of 20 μg/seedling. 
     Further, compounds 102-2, 212-2, 1-20, 7-2, 1-21, 3-20, 4-20, 3-3, 4-3, 1-22, 1-23, 5-20, 5-3, 6-3, 8-2, 4-4, 3-5, 1-501, 1-499, 1-511, 1-519, 1-523, 1-528, 1-531, 1-507, 1-516, 1-518, 1-527, 1-521, 1-42, 1-44, 1-50, 1-114, 1-118, 1-119, 1-47, 1-55, 1-124, 1-64, 1-52, 1-121, 1-53, 1-76, 1-670 and 478-2 exhibited insecticidal activity having a mortality of 80% or higher in the rate of 2 μg/seedling. 
     Meanwhile, Comparative Example 8 (Japanese Patent Application Laid-Open No. 5-78323, Compound No. 51 in Table 1) exhibited a mortality of 50% in the rate of 20 μg/seedling. 
     &lt;Soil Irrigation Treatment Test&gt; 
     Test Example 10 Pest Control Test of  Laodelphax striatellua    
     A rice seedling in pot culture was subjected to soil irrigation treatment with a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 10% acetone water. Three days after the treatment, ten second instar larvae of  Laodelphax striatella  were each released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Three days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. The test was performed in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     As a result, compounds 102-2, 1-20, 1-21, 3-20, 4-20, 3-3, 4-3, 1-22, 1-23, 5-20, 5-3, 6-3, 8-2, 5-4, 4-4, 6-4, 4-5, 3-4, 3-5, 1-150, 1-118, 1-122, 1-124, 1-64 and 1-121 exhibited high insecticidal activity having a mortality of 80% or higher in the rate of 0.05 mg/seedling. 
     Meanwhile, Comparative Example 8 (Patent Document 3 Japanese Patent Application Laid-Open No. 5-78323, Compound No. 51 in Table 1) and Comparative Example 9 (the same Compound No. 56) all exhibited a mortality of 0% in the treatment of 0.05 mg/seedling. 
     Test Example 11 Pest Control Test of  Sogatella furcifera    
     A rice seedling in pot culture was subjected to soil irrigation treatment with a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 10% acetone water. Three days after the treatment, ten second instar larvae of  Sogatella furcifera  were each released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Three days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. The test was performed in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     As a result, compounds 1-20 and 4-20 exhibited insecticidal activity having a mortality of 80% or higher in the rate of 0.01 mg/seedling. 
     Test Example 12 Pest Control Test of  Nilaparvata lugens    
     A rice seedling in pot culture was subjected to soil irrigation treatment with a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 10% acetone water. Three days after the treatment, ten second instar larvae of  Nilaparvata lugens  were each released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Three days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. The test was performed in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     As a result, compounds 1-20, 1-21, 3-20, 4-20, 1-23 and 5-20 exhibited insecticidal activity having a mortality of 80% or higher in the rate of 0.05 mg/seedling. 
     Meanwhile, Comparative Example 8 (Patent Document 3 Japanese Patent Application Laid-Open No. 5-78323, Compound No. 51 in Table 1) and Comparative Example 9 (the same Compound 56) exhibited a mortality of 15% and 0 in the treatment of 0.05 mg/seedling, respectively. 
     Test Example 13 Pest Control Test of  Oulema oryzae    
     A rice seedling in pot culture was subjected to soil irrigation treatment with a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 10% acetone water. Three days after the treatment, two second instar larvae of  Oulema oryzae  were each released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Three days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. The test was performed in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     As a result, compound 1-20 exhibited insecticidal activity having a mortality of 80% or higher in the rate of 0.05 mg/seedling. 
     Test Example 14 Pest Control Test of  Nephotettix cincticeps    
     A rice seedling in pot culture was subjected to soil irrigation treatment with a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 10% acetone water. Three days after the treatment, five second instar larvae of  Nephotettix cincticeps  were each released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Three days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. The test was performed in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     As a result, compound 1-20 exhibited insecticidal activity having a mortality of 80% or higher in the rate of 0.05 mg/seedling. 
     Effects Against Drug Resistant Pests 
     &lt;Foliar Spray Test&gt; 
     Test Example 15 Pest Control Test of  Laodelphax striatella    
     A drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 50% acetone water (0.05% Tween20 available), was foliar sprayed to a rice seedling in pot culture. After an air drying process, ten second instar larvae of  Laodelphax striatella  exhibiting drug resistance to fipronil were released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Six days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. Test in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     Further, for the origin of test pests, insects of  Laodelphax striatella  collected outdoors within the Kumamoto prefecture in 2006 were used. 
     As a result, compound 1-20 exhibited insecticidal activity having a mortality of 80% or higher by a foliar treatment at 1.25 ppm. 
     Test Example 16 Pest Control Test of  Nilaparvata lugens    
     A drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 50% acetone water (0.05% Tween20 available), was foliar sprayed to a rice seedling in pot culture. After an air drying process, second instar larvae of  Nilaparvata lugens  exhibiting drug resistance to imidacloprid were released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Six days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. Test in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     Further, for the origin of test pests, insects of  Nilaparvata lugens  collected outdoors within the Fukuoka prefecture in 2005 were used. 
     As a result, compound 1-20 exhibited insecticidal activity having a mortality of 80% or higher by a foliar treatment at 20 ppm. 
     Test Example 17 Pest Control Test of  Sogatella furcifera    
     A drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 10% acetone water (0.05% Tween20 available), was foliar sprayed to a rice seedling in pot culture. After an air drying process, second instar larvae of  Sogatella furcifera  exhibiting drug resistance to fipronil were released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Four days after the release, the larvae were observed for survival or death, the mortality of larvae was calculated by the following equation. Test in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     Further, for the origin of test pests, insects of  Sogatella furcifera  collected outdoors within the city of Odawara in 2010 were used. 
     As a result, compound 1-20 exhibited insecticidal activity having a mortality of 80% or higher by a foliar treatment at 20 ppm. 
     &lt;Soil Irrigation Test&gt; 
     Test Example 18 Pest Control Test of Drug-Resistant  Nilaparvata lugens    
     A rice seedling in pot culture was subjected to soil irrigation treatment with a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 10% acetone water. Three days after the treatment, ten second instar larvae of  Nilaparvata lugens  exhibiting drug resistance to imidacloprid were each released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Three days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. The test was performed in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     Further, for comparison, the test against some population of  Nilaparvata lugens  which is highly susceptible to imidacloprid was performed by the same method as described above, and the results thereof are shown in Table 43. As described in Table 43, compounds 1-20, 1-21, 1-22, 1-23, 3-20, 4-20 and 5-20 exhibited equivalent mortality of larvae against drug resistant populations and susceptible populations of  Nilaparvata lugens . From the test, it became obvious that 1-20, 1-21, 1-22, 1-23, 3-20, 4-20 and 5-20 exhibited high insecticidal effects even against drug resistant  Nilaparvata lugens.    
     Further, for the origin of test pests, bugs collected outdoors within the Kumamoto prefecture in 2007 as the drug resistant  Nilaparvata lugens , and bugs collected within the Kagoshima prefecture and then successively reared indoors for a long time as the imidacloprid susceptible populations of  Nilaparvata lugens  were used. 
     
       
         
           
               
               
               
             
               
                   
                 TABLE 54 
               
             
            
               
                   
                   
               
               
                   
                 Insecticidal effects against 
                   
               
               
                   
                 
                   Nilaparvata lugens 
                 
               
               
                   
                 (mortality of larvae %) 
               
            
           
           
               
               
               
               
            
               
                   
                   
                 Susceptible 
                 Drug resistant 
               
               
                   
                   
                 populations 
                 populations 
               
               
                   
                 Rate 
                 three days after 
                 three days after 
               
               
                 Compounds 
                 (mg/pot) 
                 the treatment 
                 the treatment 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 1-20 
                 0.05 
                 96 
                 100 
               
               
                   
                 0.01 
                 95 
                 81 
               
               
                 1-21 
                 0.05 
                 67 
                 50 
               
               
                 1-22 
                 0.05 
                 75 
                 60 
               
               
                 1-23 
                 0.05 
                 85 
                 70 
               
               
                 3-20 
                 0.05 
                 100 
                 100 
               
               
                 4-20 
                 0.05 
                 95 
                 100 
               
               
                 5-20 
                 0.05 
                 91 
                 100 
               
               
                 Comparative 
                 0.05 
                   
                 45 
               
               
                 Example 3 
               
               
                 (Patent 
               
               
                 Document 2 
               
               
                 Example 4) 
               
               
                 Comparative 
                 0.05 
                   
                 25 
               
               
                 Example 4 
               
               
                 (Patent 
               
               
                 Document 2 
               
               
                 Example 3) 
               
               
                 Comparative 
                 0.05 
                   
                 25 
               
               
                 Example 5 
               
               
                 (Patent 
               
               
                 Document 2 
               
               
                 Example 5) 
               
               
                 Comparative 
                 0.05 
                   
                 20 
               
               
                 Example 6 
               
               
                 (Patent 
               
               
                 Document 2 
               
               
                 Example 7) 
               
               
                 Comparative 
                 0.05 
                 15 
                 13 
               
               
                 Example 8 
               
               
                 (Patent 
               
               
                 Document 3 
               
               
                 Compound 51) 
               
               
                 Comparative 
                 0.05 
                 0 
                 31 
               
               
                 Example 9 
               
               
                 (Patent 
               
               
                 Document 3 
               
               
                 Compound 56) 
               
               
                 Imidacloprid 
                 0.05 
                 90 
                 6 
               
               
                   
                 0.01 
                 73 
                 0 
               
               
                   
               
            
           
         
       
     
     Test Example 19 Pest Control Test of  Sogatella furcifera    
     A rice seedling in pot culture was subjected to soil irrigation treatment with a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 10% acetone water. Three days after the treatment, ten second instar larvae of  Sogatella furcifera  exhibiting drug resistance to fipronil were each released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Six days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. The test was performed in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     Further, for comparison, the test against a populations of  Sogatella furcifera  which is highly susceptible to fipronil was performed by the same method as described above, and the results thereof are shown in Table 44. As shown in Table 44, compound 1-20 exhibited equivalent mortality of larvae against drug resistant populations and susceptible populations of  Sogatella furcifera . From the test, it became obvious that compound 1-20 exhibited high insecticidal effects even against drug resistant  Sogatella furcifera.    
     In addition, for the origin of test pests, bugs collected within the city of Odawara in 2010 as the drug resistant  Sogatella furcifera , and bugs collected within the city of Chigasaki in 1970 and then successively reared indoors for a long time as the susceptible populations of  Sogatella furcifera  were used. 
     
       
         
           
               
               
               
             
               
                   
                 TABLE 55 
               
             
            
               
                   
                   
               
               
                   
                 Insecticidal effects against 
                   
               
               
                   
                 
                   Sogatella furcifera 
                 
               
               
                   
                 (mortality of larvae %) 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                   
                 Susceptible 
                 Drug resistant 
               
               
                   
                   
                   
                 populations 
                 populations 
               
               
                   
                   
                 Rate 
                 six days after 
                 six days after 
               
               
                   
                 Compounds 
                 (mg/pot) 
                 the treatment 
                 the treatment 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 1-20 
                 0.01 
                 88 
                 88 
               
               
                   
                   
                 0.005 
                 75 
                 53 
               
               
                   
                 Fipronil 
                 0.05 
                   
                 90 
               
               
                   
                   
                 0.01 
                 100 
                 40 
               
               
                   
                   
                 0.005 
                 100 
               
               
                   
                   
                 0.01 
                 78 
               
               
                   
                   
               
            
           
         
       
     
     Test Example 20 Pest Control Test of  Laodelphax striatella    
     A rice seedling in pot culture was subjected to soil irrigation treatment with a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared so as to be a 10% acetone water. Three days after the treatment, ten second instar larvae of  Laodelphax striatella  exhibiting drug resistance to fipronil were each released thereto. Thereafter, the larvae were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Six days after the release, the larvae were observed for survival or death, and the mortality of larvae was calculated by the following equation. The test was performed in duplicate. 
       Mortality of larvae (%)={number of dead larvae/(number of survived larvae+number of dead larvae)}×100
 
     Further, for comparison, the test against a populations of  Laodelphax striatella  which is highly susceptible to fipronil was performed by the same method as described above, and the results thereof are shown in Table 45. As shown in Table 45, compound 1-20 exhibited equivalent mortality of larvae against drug resistant populations and susceptible populations of  Laodelphax striatella . From the test, it became obvious that compound 1-20 exhibited high insecticidal effects even against drug resistant  Laodelphax striatella.    
     In addition, for the origin of test pests, bugs collected within the Kumamoto prefecture in 2006 as the drug resistant  Laodelphax striatella , and bugs successively reared indoors for a long time as the susceptible populations of  Laodelphax striatella  were used. 
     
       
         
           
               
               
               
             
               
                   
                 TABLE 56 
               
             
            
               
                   
                   
               
               
                   
                 Insecticidal effects against 
                   
               
               
                   
                 
                   Laodelphax striatella 
                 
               
               
                   
                 (mortality of larvae %) 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                   
                 Susceptible 
                 Drug resistant 
               
               
                   
                   
                   
                 populations 
                 populations 
               
               
                   
                   
                 Rate 
                 six days after 
                 six days after 
               
               
                   
                 Compounds 
                 (mg/pot) 
                 the treatment 
                 the treatment 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 1-20 
                 0.005 
                 85 
                 79 
               
               
                   
                 Fipronil 
                 0.05 
                   
                 90 
               
               
                   
                   
                 0.02 
                   
                 76 
               
               
                   
                   
                 0.01 
                 100 
               
               
                   
                   
                 0.005 
                 89 
               
               
                   
                   
               
            
           
         
       
     
     Test Example 21 Pest Control Test of  Musca domestica    
     A drug solution of the compound of the present invention, which had been adjusted to be 50 ppm with a 40% sucrose liquid, was adsorbed on a pledget, and the pledget was put into a vial. Two adults reared indoors were released thereto. Thereafter, the adults were left to stand indoors at room temperature of 25° C. Four days after the release, the adults were observed for survival or death. When two adults were all agonized in death, it was judged to be effective. 
     As a result, compounds 223-2, 1-20, 1-21, 3-20, 4-20, 3-3, 4-3, 5-5, 6-5, 1-22, 1-23, 5-20, 6-3, 5-4, 4-4, 6-4, 4-5, 2-20, 3-4, 3-5, 1-531, 1-518, 1-43, 1-42, 1-500, 1-72, 1-150, 1-56, 1-50, 1-114, 1-44, 1-118 and 1-119 exhibited high activity that all the adults are agonized in death, in the rate at 50 ppm. 
     Test Example 22 Pest Control Test of Housefly Instar Larvae 
     Compound 1-20 was blended with an extremely small amount of DMSO, and then the resulting mixture was dissolved in deionized water to adjust the drug solution. 10 ml of the drug solution adjusted to be 30 ppm was added to 10 g of powder in which wheat bran, MF feed (Oriental Yeast Co., Ltd.) and dry yeast had been mixed in a ratio of 25:5:1, and the mixture was mixed well to prepare a bait for housefly instar larvae. A 50 ml Falcon tube was slightly filled with the bait including the compound, and 20 eggs were released thereto. The mouth of the Falcon tube was covered with a mesh-topped lid, and the tube was allowed to stand at 25° C. Twenty days after the drug treatment, the numbers of instar larvae, chrysalises and adults were measured, and the mortality of larvae, chrysalises and adults was calculated by the following equation. The test was performed by repeating each treatment twice. 
       Mortality of larvae, chrysalises and adults (%)={number of dead larvae, chrysalises and adults/(number of survived larvae, chrysalises and adults+number of dead larvae, chrysalises and adults)}×100
 
     As a result, compound 1-20 exhibited a mortality of 100% in the rate at 30 ppm. 
     Test Example 23 Pest Control Test of  Haemaphysalis longicornis    
     30 μL of a acetone solution of the compound of the present invention at 200 ppm and acetone at 10 ppm was put into a 4 mL glass vial. The glass vial was loaded into a shaker and blow-dried while being rotated to form a dry film of the compound on the internal wall of the vial. After the vial was dried for 24 hours or more, ten young mites of  Haemaphysalis longicornis  were released thereto and the lid of the vial was covered. The vial was allowed to stand in a thermostatic chamber under total dark conditions at 25° C. and the humidity of 85%. One day after the release, the insects were observed for survival or death, the mortality of insects was calculated by the following equation. The test was performed in duplicate. 
       Mortality of insects (%)={number of dead insects/(number of survived insects+number of dead insects)}×100
 
     As a result, compounds 266-2, 444-2, 1-17, 1-18, 1-19, 7-2, 1-13, 1-21, 3-3, 4-3, 5-5, 6-5, 1-22, 1-23, 5-20, 5-3, 6-3, 5-4, 4-5, 2-20, 1-47, 1-122, 1-45, 1-124, 1-52, 1-670, 1-662, 1-665, 1-667, 1-676, 478-2, 479-2, 1-51 and 1-669 exhibited insecticidal activity having a mortality of 80% or higher in the rate at 200 ppm. 
     Test Example 24 Pest Control Test of  Haemaphysalis longicornis    
     A capsule with a diameter of 2 cm and a height of 2 cm was adhered to the back of a mouse. 9.5 μg of the compound of the present invention was dissolved in ethanol, and the resulting mixture was added dropwise to the body surface of the mouse in the capsule. The capsule was sufficiently dried, then ten young mites of  Haemaphysalis longicornis  were released thereto, and the top of the capsule was hermetically sealed with a lid. The mouse was reared under conditions of 12 hours of light period and 12 hours of dark period at 25° C. in a cage. Five days after the release, the capsule was detached therefrom to measure the numbers of living and dead mites and blood-sucking individuals of young mites, and the rate of insects agonized in death was calculated according to the following equation. 
       Rate of insects agonized in death (%)={number of insects agonized in death/(number of survived insects+number of insects agonized in death)}×100
 
     As a result, compounds 1-20, 5-4, 4-5, 4-20, 1-501, 1-499, 1-516, 1-43, 1-42, 1-500, 1-72, 1-150, 1-515, 1-56, 1-50, 1-114, 1-44, 1-118, 1-119, 1-47, 1-55, 1-122, 1-45, 1-124, 1-64, 1-52, 1-121, 1-53, 1-76, 1-670, 1-671, 1-658, 1-659, 1-681, 1-662, 1-663, 1-667, 1-51 and 1-669 exhibited insecticidal activity having a rate of insects agonized in death of 80% or higher in the 9.5 μg of rate. 
     Test Example 25 Pest Control Test of  Haemaphysalis longicornis    
     Three petri dishes with a diameter of 9 cm and a height of 1 cm were adhered to the back of a dog. Compound 1-20 of the present invention was dissolved in ethanol so as to be 5.35 mg/mL, and the mixture was added dropwise to the body surface of the dog in the petri dish. The petri dish was sufficiently dried, and then thirty young mites of  Haemaphysalis longicornis  were released thereto. Each dog was housed in a cage and reared under conditions of 10 hours of light period and 14 hours of dark period at 23° C. Three days after the release, the petri dishes were detached therefrom to measure the numbers of living and dead mites and blood-sucking individuals of young mites, and the mortality of mites was calculated according to the following equation. 
       Mortality of mites (%)={number of dead mites/(number of survived mites+number of dead mites)}×100
 
     As a result, compound 1-20 exhibited a mortality of 100%. 
     Test Example 26 Pest Control Test of  Ctenocephalides felis    
     Three petri dishes with a diameter of 9 cm and a height of 1 cm were adhered to the back of a dog. Compound 1-20 of the present invention was dissolved in ethanol so as to be 5.35 mg/mL, and the mixture was added dropwise to the body surface of the dog in the petri dish. The petri dish was sufficiently dried, and then twenty insects of  Ctenocephalides felis  were released thereto. Each dog was housed in a cage and reared under conditions of 10 hours of light period and 14 hours of dark period at 23° C. Three days after the release, the petri dishes were detached therefrom to measure the numbers of living and dead insects of  Ctenocephalides felis  and blood-sucking individuals, and the mortality of insects was calculated according to the following equation. 
       Mortality of insects (%)={number of dead insects/(number of survived insects+number of dead insects)}×100
 
     As a result, compound 1-20 exhibited a mortality of 100%. 
     Test Example 27 Pest Control Test of  Coptotermes formosanus    
     A filter paper was allowed to be soaked in a drug solution of the compound of the present invention at a predetermined concentration, which had been prepared with acetone. The filter paper was sufficiently blow-dried and then put into a plastic petri dish, and 5 insects of  Coptotermes formosanus  (worker ant) were each released thereto. Thereafter, the insects were left to stand in a thermostatic chamber (16 hours of light period-8 hours of dark period) at 25° C. Seven days after the release, the insects were observed for survival or death, and the mortality of insects was calculated by the following equation. The test was performed in duplicate. 
       Mortality of insects (%)={number of dead insects/(number of survived insects+number of dead insects)}×100
 
     As a result, compound 1-20 exhibited insecticidal activity having a mortality of 100% in the rate at 0.5 μg/cm 2 . 
     The biological activities of the preferred compounds of this invention were described in Tables 57 and 58. 
     
       
         
           
               
             
               
                 TABLE 57 
               
             
            
               
                   
               
               
                 (foliar treatment) 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                 Compound 
                 Compound 
                 Compound 
                 Compound 
                 Compound 
               
               
                   
                   
                 1-20 
                 1-21 
                 3-20 
                 4-20 
                 5-20 
               
               
                   
                 Concentration 
                 % 
                 % 
                 % 
                 % 
                 % 
               
               
                 Test Example 
                 (ppm) 
                 Mortality 
                 Mortality 
                 Mortality 
                 Mortality 
                 Mortality 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Test Example1 
                 100 
                 100 
                 80 
                 55 
                 100 
                 100 
               
               
                 
                   Plutella 
                 
                 20 
                 100 
                 10 
                 0 
                 70 
                 100 
               
               
                 
                   xylostella 
                 
                 5 
                 50 
                   
                   
                   
                 20 
               
               
                 Test Example2 
                 100 
                 90 
                 55 
                 30 
                 20 
                 60 
               
               
                 
                   Spodoptera litura 
                 
               
               
                 Test Example3 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                 
                   Aphis gossypii 
                 
                 20 
                 100 
                 100 
                 100 
               
               
                   
                 5 
                 100 
                 100 
                 100 
                 100 
                 100 
               
               
                   
                 1.25 
                 75 
                 100 
                 100 
                 100 
                 55 
               
               
                   
                 0.313 
                   
                 55 
                 15 
               
               
                 Test Example4 
                 5 
                 100 
               
               
                 
                   Aulacophora 
                 
                 1.25 
                 100 
               
               
                 
                   femoralis 
                 
               
               
                 Test Example5 
                 100 
                 100 
               
               
                 
                   Callosobruchus 
                 
                 10 
                 100 
               
               
                 
                   chinensis 
                 
               
               
                 Test Example6 
                 1.25 
                 95 
               
               
                 
                   Laodelphax 
                 
               
               
                 
                   striatella 
                 
               
               
                 Test Example7 
                 100 
                 80 
                 90 
                 45 
                 60 
                 50 
               
               
                 
                   Frankliniella 
                 
                 20 
                 50 
                 80 
               
               
                 
                   occidentalis 
                 
               
               
                 Test Example8 
                 50 
                 100 
                 100 
                 100 
                 100 
               
               
                 
                   Trigonotylus 
                 
                 10 
                 100 
                 100 
                 100 
                 100 
                 17 
               
               
                 
                   caelestialium 
                 
                 2 
                 50 
                 67 
                 50 
                 33 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 58 
               
             
            
               
                   
               
               
                 soil irrigation treatment 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                 Compound 
                 Compound 
                 Compound 
                 Compound 
                 Compound 
               
               
                   
                   
                 1-20 
                 1-21 
                 3-20 
                 4-20 
                 5-20 
               
               
                   
                 Concentration 
                 % 
                 % 
                 % 
                 % 
                 % 
               
               
                 Test Example 
                 (mg/pot) 
                 Mortality 
                 Mortality 
                 Mortality 
                 Mortality 
                 Mortality 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Test Example10 
                 0.05 
                 100 
                 100 
                 90 
                 100 
                 95 
               
               
                 
                   Laodelphax 
                 
                 0.01 
                 91 
                 20 
                   
                 100 
                 52 
               
               
                 
                   striatella 
                 
                 0.005 
                 75 
                   
                   
                 35 
                 26 
               
               
                 Test Example11 
                 0.01 
                 88 
               
               
                 
                   Sogatella 
                 
                 0.005 
                 53 
               
               
                 
                   furcifera 
                 
               
               
                 Test Example12 
                 0.05 
                 100 
                 85 
                 100 
                 100 
                 100 
               
               
                 
                   Nilaparvata 
                 
                 0.01 
                 85 
                 10 
                 100 
                 96 
                 90 
               
               
                 
                   lugens 
                 
                 0.005 
                 80 
               
               
                 Test Example14 
                 0.01 
                 100 
               
               
                 
                   Nephotettix 
                 
                 0.001 
                 67 
               
               
                 
                   cincticeps 
                 
                 0.0001 
                 67