Patent Publication Number: US-2022220157-A1

Title: Adenovirus polynucleotides and polypeptides

Description:
CROSS REFERENCE TO RELATED APPLICATIONS 
     This application is a Continuation of copending U.S. application Ser. No. 15/735,872 filed Dec. 12, 2017, which is the National Phase under 35 U.S.C. § 371 of International Application No. PCT/EP2016/063297, filed on Jun. 10, 2016, which claims the benefit under 35 U.S.C. § 119(a) to Patent Application No. PCT/EP2015/063248, filed in European Patent Office on Jun. 12, 2015, Patent Application No. 1514772.1, filed in United Kingdom on Aug. 19, 2015, and Patent Application No. 1510357.5, filed in United Kingdom on Jun. 12, 2015, all of which are hereby expressly incorporated by reference into the present application. 
    
    
     FIELD OF THE INVENTION 
     The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimp adenovirus ChAd155, as well as to recombinant polynucleotides, vectors, adenoviruses and compositions comprising said polynucleotide and polypeptide sequences. 
     BACKGROUND OF THE INVENTION 
     Adenovirus has been widely used for gene transfer applications due to its ability to achieve highly efficient gene transfer in a variety of target tissues and large transgene capacity. Conventionally, E1 genes of adenovirus are deleted and replaced with a transgene cassette consisting of the promoter of choice, cDNA sequence of the gene of interest and a poly A signal, resulting in a replication defective recombinant virus. 
     Recombinant adenoviruses are useful in gene therapy and as vaccines. Viral vectors based on chimpanzee adenovirus represent an alternative to the use of human derived Ad vectors for the development of genetic vaccines. Adenoviruses isolated from chimpanzees are closely related to adenoviruses isolated from humans as demonstrated by their efficient propagation in cells of human origin. However, since human and chimp adenoviruses are close relatives, serologic cross reactivity between the two virus species is possible. 
     There is a demand for vectors which effectively deliver molecules to a target and minimize the effect of pre-existing immunity to selected adenovirus serotypes in the population. One aspect of pre-existing immunity that is observed in humans is humoral immunity, which can result in the production and persistence of antibodies that are specific for adenoviral proteins. The humoral response elicited by adenovirus is mainly directed against the three major structural capsid proteins: fiber, penton and hexon. 
     Vectors, compositions and methods of the present invention may have one or more following improved characteristics over the prior art, including but not limited to higher productivity, improved immunogenicity and increased transgene expression. Vectors of the present invention may find use in the expression of one or more immunogens useful to immunise a human or non-human animal against a pathogen. 
     Respiratory syncytial virus (RSV) is a highly contagious human pathogen that causes respiratory tract infections in people of all ages. During the first year of life, 50-70% of infants are infected with RSV and essentially all children have had an RSV infection by their second birthday. The risk for severe RSV-associated lower respiratory tract infections (LRTI) is highest in infants below 6 months of age and is a leading cause for hospitalization. Infection with RSV does not confer full protective immunity. Symptomatic RSV re-infections are common later in life and continue throughout adulthood. These re-infections generally go undiagnosed because they usually present as common acute upper respiratory tract infections. In more vulnerable persons (e.g., immunocompromised adults or elderly), re-infections can however also lead to severe disease. 
     To date, no vaccine is available against RSV and treatment of RSV disease is largely symptomatic and supportive care. The antiviral drug ribavirin is currently the only approved antiviral therapy for RSV treatment, but its use is restricted to severe hospitalized cases due to uncertainties regarding its efficacy, difficulty in administration (aerosol) and high cost [American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis, 2006]. RSV-specific monoclonal antibodies (palivizumab, Synagis™, Medimmune) are indicated for the prevention of serious LRTIs requiring hospitalization caused by RSV in children at high risk for RSV disease but are not indicated or recommended in the general, healthy infant population due to high cost and the need for repeated administration. 
     In the late 1960s, a formalin-inactivated whole virus RSV vaccine (FI-RSV) tested in clinical trials led to more severe clinical symptoms upon subsequent natural infection with RSV in children under the age of two [Kim, 1969; Chin, 1969]). This experience has led to heightened safety concerns with pediatric RSV vaccine candidates. Since that time, several investigational vaccines have been and continue to be explored, including live attenuated viral vaccines and those based upon purified or recombinant viral proteins. However there is not yet a licensed vaccine for the prevention of RSV disease. 
     SUMMARY OF THE INVENTION 
     There is provided an isolated polynucleotide, wherein the polynucleotide encodes a polypeptide selected from the group consisting of: 
     (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1, 
     (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and 
     (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3. 
     Also provided is a recombinant polynucleotide comprising a polynucleotide selected from the group consisting of: 
     (a) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 1, 
     (b) a polynucleotide which encodes a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and 
     (c) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 3. 
     Also provided is a recombinant vector comprising a polynucleotide selected from the group consisting of: 
     (a) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 1, 
     (b) a polynucleotide which encodes a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and 
     (c) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 3. 
     Also provided is a recombinant adenovirus comprising at least one polynucleotide or polypeptide selected from the group consisting of: 
     (a) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 1, 
     (b) a polynucleotide which encodes a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, 
     (c) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 3, 
     (d) a polypeptide having the amino acid sequence according to SEQ ID NO: 1, 
     (e) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and 
     (f) a polypeptide having the amino acid sequence according to SEQ ID NO: 3. 
     Also provided is a composition comprising at least one of the following: 
     (a) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 1, 
     (b) a polynucleotide which encodes a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, 
     (c) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 3, 
     (d) a polypeptide having the amino acid sequence according to SEQ ID NO: 1, 
     (e) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, 
     (f) a polypeptide having the amino acid sequence according to SEQ ID NO: 3, 
     (g) a vector comprising a polynucleotide as described in (a), (b) or (c) above, and 
     (h) a recombinant adenovirus comprising a polynucleotide as described in (a), (b) or (c) above, and a pharmaceutically acceptable excipient. 
     Also provided is a cell comprising at least one of the following: 
     (a) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 1, 
     (b) a polynucleotide which encodes a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, 
     (c) a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 3, 
     (d) a polypeptide having the amino acid sequence according to SEQ ID NO: 1, 
     (e) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, 
     (f) a polypeptide having the amino acid sequence according to SEQ ID NO: 3, 
     (g) a vector comprising a polynucleotide as described in (a), (b) or (c) above, and 
     (h) a recombinant adenovirus comprising a polynucleotide as described in (a), (b) or (c) above. 
     Also provided is an isolated adenoviral polypeptide selected from the group consisting of: 
     (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1, 
     (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and 
     (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3. 
     Also provided is an isolated polynucleotide, vector, recombinant adenovirus, composition or cell comprising or consisting of the sequence according to SEQ ID NO: 6. 
    
    
     
       DESCRIPTION OF THE FIGURES 
         FIG. 1A-C —Alignment of fiber protein sequences from the indicated simian adenoviruses.
         ChAd3 (SEQ ID NO:27)   PanAd3 (SEQ ID NO:28)   ChAd17 (SEQ ID NO:29)   ChAd19 (SEQ ID NO:30)   ChAd24 (SEQ ID NO:31)   ChAd155 (SEQ ID NO:1)   ChAd11 (SEQ ID NO:32)   ChAd20 (SEQ ID NO:33)   ChAd31 (SEQ ID NO:34)   PanAd1 (SEQ ID NO:35)   PanAd2 (SEQ ID NO:36)       

         FIG. 2 —Flow diagram for production of specific ChAd155 BAC and plasmid vectors 
         FIG. 3 —Species C BAC Shuttle #1365 schematic 
         FIG. 4 —pArsChAd155 Ad5E4orf6-2 (#1490) schematic 
         FIG. 5 —pChAd155/RSV schematic 
         FIG. 6 —BAC ChAd155/RSV schematic 
         FIG. 7 —Productivty of ChAd3 and ChAd155 vectors expressing an HIV Gag transgene (Experiment 1) 
         FIG. 8 —Productivity of ChAd3 and ChAd155 vectors expressing an HIV Gag transgene (Experiment 2) 
         FIG. 9 —Productivity of PanAd3 and ChAd155 vectors expressing RSV transgene 
         FIG. 10 —Expression levels of ChAd3 and ChAd155 vectors expressing an HIV Gag transgene 
         FIG. 11 —Expression levels of PanAd3 and ChAd155 vectors expressing an HIV Gag transgene—Western Blot 
         FIG. 12 —Immunogenicity of ChAd3 and ChAd155 vectors expressing an HIV Gag transgene—IFN-gamma ELISpot 
         FIG. 13 —Immunogenicity of PanAd3 and ChAd155 vectors expressing an HIV Gag transgene—IFN-gamma ELISpot 
         FIG. 14 —Schematic of the synthetic DNA fragment used to express RSV antigens by the ChAd155-RSV vector 
         FIG. 15 —Anti-F antibody titers induced by ChAd155-RSV and PanAd3-RSV in BALB/c mice 
         FIG. 16 —RSV titers in nasal tissues (A) and lung homogenates (B), RSV neutralizing antibody (C) and pathology score (D) after viral challenge 
         FIG. 17 —Kinetics of induction of bRSV-specific IgG (A) and RSV neutralizing antibodies (B) 
         FIG. 18 —Kinetics of mean virus titers in nasopharyngeal swabs detected up to day 6 post bRSV challenge 
         FIG. 19 —Effect of vaccination on bRSV replication in the lower respiratory tract 
         FIG. 20 —Effect of vaccination on gross pneumonic consolidation 6 days post bRSV challenge 
         FIG. 21 —Effect of vaccination on the pulmonary inflammatory response 6 days post bRSV challenge 
     
    
    
     DESCRIPTION OF THE SEQUENCES 
     
         
         
           
             SEQ ID NO: 1—Polypeptide sequence of ChAd155 fiber 
             SEQ ID NO: 2—Polynucleotide sequence encoding ChAd155 fiber 
             SEQ ID NO: 3—Polypeptide sequence of ChAd155 penton 
             SEQ ID NO: 4—Polynucleotide sequence encoding ChAd155 penton 
             SEQ ID NO: 5—Polypeptide sequence of ChAd155 hexon 
             SEQ ID NO: 6—Polynucleotide sequence encoding ChAd155 hexon 
             SEQ ID NO: 7—Polynucleotide sequence encoding ChAd155#1434 
             SEQ ID NO: 8—Polynucleotide sequence encoding ChAd155#1390 
             SEQ ID NO: 9—Polynucleotide sequence encoding ChAd155#1375 
             SEQ ID NO: 10—Polynucleotide sequence encoding wild type ChAd155 
             SEQ ID NO: 11—Polynucleotide sequence encoding ChAd155/RSV 
             SEQ ID NO: 12—Polynucleotide sequence encoding the CASI promoter 
             SEQ ID NO: 13—Ad5orf6 primer 1 polynucleotide sequence 
             SEQ ID NO: 14—Ad5orf6 primer 2 polynucleotide sequence 
             SEQ ID NO: 15—BAC/CHAd155 ΔE1_TetO hCMV RpsL-Kana primer 1 polynucleotide sequence 
             SEQ ID NO: 16—BAC/CHAd155 ΔE1_TetO hCMV RpsL-Kana (#1375) primer 2 polynucleotide sequence 
             SEQ ID NO: 17—1021-FW E4 Del Step1 primer polynucleotide sequence 
             SEQ ID NO: 18—1022-RW E4 Del Step1 primer polynucleotide sequence 
             SEQ ID NO: 19—1025-FW E4 Del Step2 primer polynucleotide sequence 
             SEQ ID NO: 20—1026-RW E4 Del Step2 primer polynucleotide sequence 
             SEQ ID NO: 21—91-SubMonte FW primer polynucleotide sequence 
             SEQ ID NO: 22—890-BghPolyA RW primer polynucleotide sequence 
             SEQ ID NO: 23—CMVfor primer polynucleotide sequence 
             SEQ ID NO: 24—CMVrev primer polynucleotide sequence 
             SEQ ID NO: 25—CMVFAM-TAMRA qPCR probe polynucleotide sequence 
             SEQ ID NO: 26—Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element (WPRE) polynucleotide sequence 
             SEQ ID NO: 27—Amino acid sequence for the fiber protein of ChAd3 
             SEQ ID NO: 28—Amino acid sequence for the fiber protein of PanAd3 
             SEQ ID NO: 29—Amino acid sequence for the fiber protein of ChAd17 
             SEQ ID NO: 30—Amino acid sequence for the fiber protein of ChAd19 
             SEQ ID NO: 31—Amino acid sequence for the fiber protein of ChAd24 
             SEQ ID NO: 32—Amino acid sequence for the fiber protein of ChAd11 
             SEQ ID NO: 33—Amino acid sequence for the fiber protein of ChAd20 
             SEQ ID NO: 34—Amino acid sequence for the fiber protein of ChAd31 
             SEQ ID NO: 35—Amino acid sequence for the fiber protein of PanAd1 
           
         
       
    
     SEQ ID NO: 36—Amino acid sequence for the fiber protein of PanAd2 
     SEQ ID NO: 37—RSV FΔTM-N-M2-1 amino acid sequence
         SEQ ID NO: 38—HIV Gag polynucleotide sequence       

     DETAILED DESCRIPTION OF THE INVENTION 
     Adenovirus 
     Adenoviruses have a characteristic morphology with an icosahedral capsid comprising three major proteins, hexon (II), penton base (III) and a knobbed fiber (IV), along with a number of other minor proteins, VI, VIII, IX, IIIa and IVa2. The virus genome is a linear, double-stranded DNA. The virus DNA is intimately associated with the highly basic protein VII and a small peptide pX (formerly termed mu). Another protein, V, is packaged with this DNA-protein complex and provides a structural link to the capsid via protein VI. The virus also contains a virus-encoded protease, which is necessary for processing of some of the structural proteins to produce mature infectious virus. 
     The adenoviral genome is well characterized. There is general conservation in the overall organization of the adenoviral genome with respect to specific open reading frames being similarly positioned, e.g. the location of the E1A, E1B, E2A, E2B, E3, E4, L1, L2, L3, L4 and L5 genes of each virus. Each extremity of the adenoviral genome comprises a sequence known as an inverted terminal repeat (ITR), which is necessary for viral replication. The virus also comprises a virus-encoded protease, which is necessary for processing some of the structural proteins required to produce infectious virions. The structure of the adenoviral genome is described on the basis of the order in which the viral genes are expressed following host cell transduction. More specifically, the viral genes are referred to as early (E) or late (L) genes according to whether transcription occurs prior to or after onset of DNA replication. In the early phase of transduction, the E1A, E1B, E2A, E2B, E3 and E4 genes of adenovirus are expressed to prepare the host cell for viral replication. During the late phase of infection, expression of the late genes L1-L5, which encode the structural components of the virus particles, is activated. 
     Adenoviruses are species-specific and different serotypes, i.e., types of viruses that are not cross-neutralized by antibodies, have been isolated from a variety of mammalian species. For example, more than 50 serotypes have been isolated from humans which are divided into six subgroups (A-F; B is subdivided into B1 and B2) based on sequence homology and on their ability to agglutinate red blood cells (Tatsis and Ertl  Molecular Therapy  (2004) 10:616-629). Numerous adenoviruses have been isolated from nonhuman simians such as chimpanzees, bonobos, rhesus macaques and gorillas, and they are classified into the same human groups based on phylogenetic relationships based on hexon or fiber sequences (Colloca et al. (2012) Science Translational Medicine 4:1-9; Roy et al. (2004)  Virology  324: 361-372; Roy et al. (2010)  Journal of Gene Medicine  13:17-25). 
     Adenovirus Capsid Proteins including the Fiber Protein and Polynucleotides Encoding these Proteins 
     As outlined above, the adenoviral capsid comprises three major proteins, hexon, penton and fiber. The hexon accounts for the majority of the structural components of the capsid, which consists of 240 trimeric hexon capsomeres and 12 penton bases. The hexon has three conserved double barrels, while the top has three towers, each tower containing a loop from each subunit that forms most of the capsid. The base of hexon is highly conserved between adenoviral serotypes, while the surface loops are variable (Tatsis and Ertl  Molecular Therapy  (2004) 10:616-629). 
     Penton is another adenoviral capsid protein that forms a pentameric base to which fiber attaches. The trimeric fiber protein protrudes from the penton base at each of the 12 vertices of the capsid and is a knobbed rod-like structure. A remarkable difference in the surface of adenovirus capsids compared to that of most other icosahedral viruses is the presence of the long, thin fiber protein. The primary role of the fiber protein is the tethering of the viral capsid to the cell surface via its interaction with a cellular receptor. 
     The fiber proteins of many adenovirus serotypes share a common architecture: an N-terminal tail, a central shaft made of repeating sequences, and a C-terminal globular knob domain (or “head”). The central shaft domain consists of a variable number of beta-repeats. The beta-repeats connect to form an elongated structure of three intertwined spiralling strands that is highly rigid and stable. The shaft connects the N-terminal tail with the globular knob structure, which is responsible for interaction with the target cellular receptor. The globular nature of the adenovirus knob domain presents large surfaces for binding the receptor laterally and apically. The effect of this architecture is to project the receptor-binding site far from the virus capsid, thus freeing the virus from steric constraints presented by the relatively flat capsid surface. 
     Although fibers of many adenovirus serotypes have the same overall architecture, they have variable amino acid sequences that influence their function as well as structure. For example, a number of exposed regions on the surface of the fiber knob present an easily adaptable receptor binding site. The globular shape of the fiber knob allows receptors to bind at the sides of the knob or on top of the fiber knob. These binding sites typically lie on surface-exposed loops connecting beta-strands that are poorly conserved among human adenoviruses. The exposed side chains on these loops give the knob a variety of surface features while preserving the tertiary and quaternary structure. For example, the electrostatic potential and charge distributions at the knob surfaces can vary due to the wide range of isoelectric points in the fiber knob sequences, from pl approximately 9 for Ad 8, Ad 19, and Ad 37 to approximately 5 for subgroup B adenoviruses. As a structurally complex virus ligand, the fiber protein allows the presentation of a variety of binding surfaces (knob) in a number of orientations and distances (shaft) from the viral capsid. 
     One of the most obvious variations between some serotypes is fiber length. Studies have shown that the length of the fiber shaft strongly influences the interaction of the knob and the virus with its target receptors. Further, fiber proteins between serotypes can also vary in their ability to bend. Although beta-repeats in the shaft form a highly stable and regular structure, electron microscopy (EM) studies have shown distinct hinges in the fiber. Analysis of the protein sequence from several adenovirus serotype fibers pinpoints a disruption in the repeating sequences of the shaft at the third beta-repeat from the N-terminal tail, which correlates strongly with one of the hinges in the shaft, as seen by EM. The hinges in the fiber allow the knob to adopt a variety of orientations relative to the virus capsid, which may circumvent steric hindrances to receptor engagement requiring the correct presentation of the receptor binding site on the knob. For example, the rigid fibers of subgroup D Ads thus require a flexible receptor or one prepositioned for virus attachment, as they are unable to bend themselves. (Nicklin et al  Molecular Therapy  2005 12:384-393) 
     The identification of specific cell receptors for different Ad serotypes and the knowledge of how they contribute to tissue tropism have been achieved through the use of fiber pseudotyping technology. Although Ads of some subgroups use CAR as a primary receptor, it is becoming clear that many Ads use alternate primary receptors, leading to vastly different tropism in vitro and in vivo. The fibers of these serotypes show clear differences in their primary and tertiary structures, such as fiber shaft rigidity, the length of the fiber shaft, and the lack of a CAR binding site and/or the putative HSPG binding motif, together with the differences in net charge within the fiber knob. Pseudotyping Ad 5 particles with an alternate fiber shaft and knob therefore provides an opportunity to remove important cell binding domains and, in addition, may allow more efficient (and potentially more cell-selective) transgene delivery to defined cell types compared to that achieved with Ad 5. Neutralization of fiber-pseudotyped Ad particles may also be reduced if the fibers used are from Ads with lower seroprevalence in humans or experimental models, a situation that favours successful administration of the vector (Nicklin et al  Molecular Therapy  (2005) 12:384-393). Furthermore, full length fiber as well as isolated fiber knob regions, but not hexon or penton alone, are capable of inducing dendritic cell maturation and are associated with induction of a potent CD8+ T cell response (Molinier-Frenkel et al.  J. Biol. Chem.  (2003) 278:37175-37182). Taken together, adenoviral fiber plays an important role in at least receptor-binding and immunogenicity of adenoviral vectors. 
     Illustrating the differences between the fiber proteins of Group C simian adenoviruses is the alignment provided in  FIG. 1 . A striking feature is that the fiber sequences of these adenoviruses can be broadly grouped into having a long fiber, such as ChAd155, or a short fiber, such as ChAd3. This length differential is due to a 36 amino acid deletion at approximately position 321 in the short fiber relative to the long fiber. In addition, there are a number of amino acid substitutions that differ between the short versus long fiber subgroup yet are consistent within each subgroup. While the exact function of these differences have not yet been elucidated, given the function and immunogenicity of fiber, they are likely to be significant. It has been shown that one of the determinants of viral tropism is the length of the fiber shaft. It has been demonstrated that an Ad5 vector with a shorter shaft has a lower efficiency of binding to CAR receptor and a lower infectivity (Ambriović-Ristov A. et al.: Virology. (2003) 312(2):425-33): It has been speculated that this impairment is the results of an increased rigidity of the shorter fiber leading to a less efficient attachment to the cell receptor (Wu, E et al.: J Virol. (2003) 77(13): 7225-7235). These studies may explain the improved properties of ChAd155 carrying a longer and more flexible fiber in comparison with the previously described ChAd3 and PanAd3 carrying a fiber with a shorter shaft. 
     In one aspect of the invention there is provided isolated fiber, penton and hexon capsid polypeptides of chimp adenovirus ChAd155 and isolated polynucleotides encoding the fiber, penton and hexon capsid polypeptides of chimp adenovirus ChAd155. 
     All three capsid proteins are expected to contribute to low seroprevalence and can, thus, be used independently from each other or in combination to suppress the affinity of an adenovirus to preexisting neutralizing antibodies, e.g. to manufacture a recombinant adenovirus with a reduced seroprevalence. Such a recombinant adenovirus may be a chimeric adenovirus with capsid proteins from different serotypes with at least a fiber protein from ChAd155. 
     The ChAd155 fiber polypeptide sequence is provided in SEQ ID NO: 1. 
     The ChAd155 penton polypeptide sequence is provided in SEQ ID NO: 3. 
     The ChAd155 hexon polypeptide sequence is provided in SEQ ID NO: 5. 
     Polypeptides, Recombinant Adenoviruses, Compositions or Cells comprising Polypeptide Sequences of ChAd155 Fiber or a Functional Derivative thereof 
     Suitably the isolated polypeptide, recombinant adenovirus, composition or cell of the invention comprises a polypeptide having the amino acid sequence according to SEQ ID NO: 1. 
     Suitably the polypeptide, recombinant adenovirus, composition or cell of the invention comprises a polypeptide which is a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1. Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1 has an amino acid sequence which is at least 80% identical, such as at least 85.0% identical, such as at least 90% identical, such as at least 91.0% identical, such as at least 93.0% identical, such as at least 95.0% identical, such as at least 97.0% identical, such as at least 98.0% identical, such as at least 99.0% identical, such as at least 99.2% identical, such as at least 99.4% identical, such as 99.5% identical, such as at least 99.6% identical, such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO: 1. Alternatively the functional derivative has no more than 130, more suitably no more than 120, more suitably no more than 110, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 1. 
     Suitably the polypeptide, recombinant adenovirus, composition or cell according to the invention further comprises: 
     (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 3; or 
     (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 3, wherein the functional derivative has an amino acid sequence which is at least 50.0% identical over its entire length to the amino acid sequence of SEQ ID NO: 3, and/or 
     (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 5; or 
     (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 5, wherein the functional derivative has an amino acid sequence which is at least 50% identical over its entire length to the amino acid sequence of SEQ ID NO: 5. 
     Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 3 has an amino acid sequence which is at least 60.0%, such as at least 70.0%, such as at least 80.0%, such as at least 85.0%, such as at least 90.0%, such as at least 91.0% identical, such as at least 93.0% identical, such as at least 95.0% identical, such as at least 97.0% identical, such as at least 98.0% identical, such as at least 99.0%, such as at least 99.2%, such as at least 99.4%, such as 99.5% identical, such as at least 99.6%, such as 99.7% identical such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO: 3. Alternatively the functional derivative has no more than 300, more suitably no more than 250, more suitably no more than 200, more suitably no more than 150, more suitably no more than 125, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 3. 
     Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 5 has an amino acid sequence which is at least 60.0%, such as at least 70.0%, such as at least 80.0%, such as at least 85.0%, such as at least 90.0%, such as at least 91.0% identical, such as at least 93.0% identical, such as at least 95.0% identical, such as at least 97.0% identical, such as at least 98.0% identical, such as at least 99.0%, such as at least 99.2%, such as at least 99.4%, such as 99.5% identical, such as at least 99.6%, such as 99.7% identical such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO: 5. Alternatively the functional derivative has no more than 500, more suitably no more than 400, more suitably no more than 450, more suitably no more than 300, more suitably no more than 250, more suitably no more than 200, more suitably no more than 150, more suitably no more than 125, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 5. 
     Polypeptides, Recombinant Adenoviruses, Compositions or Cells comprising Polypeptide Sequences of ChAd155 Penton 
     Suitably the polypeptide, recombinant adenovirus, composition or cell of the invention comprises a polypeptide having the amino acid sequence according to SEQ ID NO: 3. 
     Suitably the polypeptide, recombinant adenovirus, composition or cell of the invention further comprises: 
     (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1; or 
     (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1 and/or 
     (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 5; or 
     (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 5, wherein the functional derivative has an amino acid sequence which is at least 60% identical over its entire length to the amino acid sequence of SEQ ID NO: 5. 
     Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1 has an amino acid sequence which is at least 60.0% identical, such as at least 70.0% identical, such as at least 80.0% identical, such as at least 85.0% identical, such as at least 87.0% identical, such as at least 89.0% identical, such as at least 91.0% identical, such as at least 93.0% identical, such as at least 95.0% identical, such as at least 97.0% identical, such as at least 98.0% identical, such as at least 99.0% identical, such as at least 99.2%, such as at least 99.4%, such as 99.5% identical, such as at least 99.6%, such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO: 1. Alternatively the functional derivative has no more than 130, more suitably no more than 120, more suitably no more than 110, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 1. 
     Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 5 has an amino acid sequence which is at least 60.0%, such as at least 70.0%, such as at least 80.0%, such as at least 85.0%, such as at least 90.0%, such as at least 95.0%, such as at least 97.0%, such as at least 99.0%, such as at least 99.0%, such as at least 99.2%, such as at least 99.4%, such as 99.5% identical, such as at least 99.6%, such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO:5. Alternatively the functional derivative has no more than 500, more suitably no more than 400, more suitably no more than 450, more suitably no more than 300, more suitably no more than 250, more suitably no more than 200, more suitably no more than 150, more suitably no more than 125, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 5. 
     Isolated Polynucleotides, Vectors, Recombinant Adenoviruses, Compositions or Cells comprising Polynucleotides Encoding ChAd155 Fiber or a Functional Derivative thereof 
     Suitably the isolated polynucleotide, vector, recombinant adenovirus, thereof composition or cell of the invention comprises a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 1. Suitably the polynucleotide has a sequence according to SEQ ID NO: 2. 
     Alternatively, the polynucleotide, vector, recombinant adenovirus, composition or cell of the invention comprises a polynucleotide which encodes a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1. Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1 has an amino acid sequence which is at least 80% identical, such as at least 85.0% identical, such as at least 90% identical, such as at least 91.0% identical, such as at least 93.0% identical, such as at least 95.0% identical, such as at least 97.0% identical, such as at least 98.0% identical, such as at least 99.0% identical, such as at least 99% identical, such as at least 99.4% identical, such as at least 99.6% identical, such as at least 99.8% identical over its entire length to the amino acid sequence of SEQ ID NO: 1. Alternatively the functional derivative has no more than 130, more suitably no more than 120, more suitably no more than 110, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 1. 
     Suitably the polynucleotide, vector, recombinant adenovirus, composition or cell of the invention further comprises a polynucleotide encoding: 
     (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 3; or 
     (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 3, wherein the functional derivative has an amino acid sequence which is at least 50.0% identical over its entire length to the amino acid sequence of SEQ ID NO: 3, and/or 
     (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 5; or 
     (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 5, wherein the functional derivative has an amino acid sequence which is at least 50% identical over its entire length to the amino acid sequence of SEQ ID NO: 5. 
     Suitably the functional derivative of the polypeptide having the amino acid sequence according to SEQ ID NO: 3 has an amino acid sequence which is at least 60.0%, such as at least 70.0%, such as at least 80.0%, such as at least 85.0%, such as at least 90.0%, such as at least 91.0% identical, such as at least 93.0% identical, such as at least 95.0% identical, such as at least 97.0% identical, such as at least 98.0% identical, such as at least 99.0%, such as at least 99%, such as at least 99.4%, such as at least 99.6%, such as at least 99.8% identical over its entire length to the amino acid sequence of SEQ ID NO: 3. Alternatively the functional derivative has no more than 300, more suitably no more than 250, more suitably no more than 200, more suitably no more than 150, more suitably no more than 125, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 3. 
     Suitably the functional derivative of the polypeptide having the amino acid sequence according to SEQ ID NO: 5 has an amino acid sequence which is at least 60.0%, such as at least 70.0%, such as at least 80.0%, such as at least 85.0%, such as at least 90.0%, such as at least 95.0%, such as at least 97.0%, such as at least 98.0%, such as at least 99.0%, such as at least 99.2%, such as at least 99.4%, such as 99.5% identical, such as at least 99.6%, such as 99.7% identical such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO: 5. Alternatively the functional derivative has no more than 500, more suitably no more than 400, more suitably no more than 450, more suitably no more than 300, more suitably no more than 250, more suitably no more than 200, more suitably no more than 150, more suitably no more than 125, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 5. 
     Isolated Polynucleotides, Vectors, Recombinant Adenoviruses, Compositions or Cells comprising Polynucleotides Encoding ChAd155 Penton 
     Suitably the isolated polynucleotide, vector, recombinant adenovirus, composition or cell of the invention comprises a polynucleotide which encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 3. Suitably the polynucleotide has a sequence according to SEQ ID NO: 4. 
     Suitably the polynucleotide, vector, recombinant adenovirus, composition or cell of the invention further comprises a polynucleotide encoding: 
     (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1; or 
     (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 50% identical over its entire length to the amino acid sequence of SEQ ID NO: 1 and/or 
     (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 5; or 
     (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 5, wherein the functional derivative has an amino acid sequence which is at least 50% identical over its entire length to the amino acid sequence of SEQ ID NO: 5. 
     Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1 has an amino acid sequence which is at least 60.0% identical, such as at least 70.0% identical, such as at least 80.0% identical, such as at least 85.0% identical, such as at least 87.0% identical, such as at least 89.0% identical, such as at least 91.0% identical, such as at least 93.0% identical, such as at least 95.0% identical, such as at least 97.0% identical, such as at least 98.0% identical, such as at least 99.0%, such as at least 99.2%, such as at least 99.4%, such as 99.5% identical, such as at least 99.6%, such as 99.7% identical such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO: 1. Alternatively the functional derivative has no more than 130, more suitably no more than 120, more suitably no more than 110, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 1. 
     Suitably the functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 5 has an amino acid sequence which is at least 60.0%, such as at least 70.0%, such as at least 80.0%, such as at least 85.0%, such as at least 90.0%, such as at least 95.0%, such as at least 97.0%, such as at least 98.0%, such as at least 99.0%, such as at least 99.2%, such as at least 99.4%, such as 99.5% identical, such as at least 99.6%, such as 99.7% identical such as at least 99.8% identical, such as 99.9% identical over its entire length to the amino acid sequence of SEQ ID NO: 5. Alternatively the functional derivative has no more than 500, more suitably no more than 400, more suitably no more than 450, more suitably no more than 300, more suitably no more than 250, more suitably no more than 200, more suitably no more than 150, more suitably no more than 125, more suitably no more than 100, more suitably no more than 90, more suitably no more than 80, more suitably no more than 70, more suitably no more than 60, more suitably no more than 50, more suitably no more than 40, more suitably no more than 30, more suitably no more than 20, more suitably no more than 10, more suitably no more than 5, more suitably no more than 4, more suitably no more than 3, more suitably no more than 2, more suitably no more than 1 addition(s), deletion(s) or substitutions(s) compared to SEQ ID NO: 5. 
     ChAd155 Backbones 
     The invention provides isolated polynucleotide sequences of chimp adenovirus ChAd155, including that of wild type, unmodified ChAd155 (SEQ ID NO: 10) and modified backbone constructs of ChAd155. These modified backbone constructs include ChAd155#1434 (SEQ ID NO: 7), ChAd155#1390 (SEQ ID NO: 8) and ChAd155#1375 (SEQ ID NO: 9). ChAd155 backbones may be used in the construction of recombinant replication-competent or replication-incompetent adenoviruses for example for the delivery of transgenes. 
     Annotation of the ChAd155 wild type sequence (SEQ ID NO: 10) sequence is provided below. 
     
       
         
           
               
            
               
                   
               
               
                 LOCUS ChAd155 37830 bp DNA linear 10-JUN-2015 
               
            
           
           
               
               
            
               
                 DEFINITION 
                 Chimp adenovirus 155, complete genome. 
               
               
                 COMMENT 
                 Annotation according to alignment of ChAd155 against  
               
               
                   
                 the human Adenovirus 2 reference strain NC_001405 
               
               
                   
                 Two putative ORFs in the E3 region added manually 
               
               
                 FEATURES 
                 Location/Qualifiers 
               
               
                   
               
               
                 source 
                 1 . . . 37830 
               
               
                   
                 /organism = “Chimpanzee adenovirus 155” 
               
               
                   
                 /mol_type =  “genomic DNA” 
               
               
                   
                 /acronym = “ChAd155” 
               
               
                   
               
               
                 repeat_region 
                 1 . . . 101 
               
               
                   
                 /standard_name = “ITR” 
               
               
                   
                 /rpt_type = inverted 
               
               
                   
               
               
                 gene 
                 466 . . . 1622 
               
               
                   
                 /gene = “E1A” 
               
               
                   
               
               
                 TATA_signal 
                 466 . . . 471 
               
               
                   
                 /gene = “E1A” 
               
               
                   
               
               
                 prim_transcript 
                 497 . . . 1622 
               
               
                   
                 /gene = “E1A” 
               
               
                   
               
               
                 CDS 
                 join(577 . . . 1117, 1231 . . . 1532) 
               
               
                   
                 /gene = “E1A” 
               
               
                   
                 /product = “E1A_280R” 
               
               
                   
               
               
                 CDS 
                 join(577 . . . 979, 1231 . . . 1532) 
               
               
                   
                 /gene = “E1A” 
               
               
                   
                 /product = “E1A_243R” 
               
               
                   
               
               
                 polyA_signal 
                 1600 . . . 1605 
               
               
                   
                 /gene = “E1A” 
               
               
                   
               
               
                 gene 
                 1662 . . . 4131 
               
               
                   
                 /gene = “E1B” 
               
               
                   
               
               
                 TATA_signal 
                 1662 . . . 1667 
               
               
                   
                 /gene = “E1B” 
               
               
                   
               
               
                 prim_transcript 
                 1692 . . . 4131 
               
               
                   
                 /gene = “E1B” 
               
               
                   
               
               
                 CDS 
                 1704 . . . 2267 
               
               
                   
                 /gene = “E1B” 
               
               
                   
                 /product = “E1B_19K” 
               
               
                   
               
               
                 CDS 
                 2009 . . . 3532 
               
               
                   
                 /gene = “E1B” 
               
               
                   
                 /product = “E1B_55K” 
               
               
                   
               
               
                 gene 
                 3571 . . . 4131 
               
               
                   
                 /gene = “IX” 
               
               
                   
               
               
                 TATA_signal 
                 3571 . . . 3576 
               
               
                   
                 /gene = “IX” 
               
               
                   
               
               
                 prim_transcript 
                 3601 . . . 4131 
               
               
                   
                 /gene = “IX” 
               
               
                   
               
               
                 CDS 
                 3628 . . . 4092 
               
               
                   
                 /gene = “IX” 
               
               
                   
                 /product = “IX” 
               
               
                   
               
               
                 polyA_signal 
                 4097 . . . 4102 
               
               
                   
                 /note = “E1B, IX” 
               
               
                   
               
               
                 gene 
                 complement(4117 . . . 27523) 
               
               
                   
                 /gene = “E2B” 
               
               
                   
               
               
                 prim_transcript 
                 complement(4117 . . . 27494) 
               
               
                   
                 /gene = “E2B” 
               
               
                   
               
               
                 gene 
                 complement(4117 . . . 5896) 
               
               
                   
                 /gene = “IVa2” 
               
               
                   
               
               
                 prim_transcript 
                 complement(4117 . . . 5896) 
               
               
                   
                 /gene = “IVa2” 
               
               
                   
               
               
                 CDS 
                 complement(join(4151 . . . 5487, 5766 . . . 5778)) 
               
               
                   
                 /gene = “IVa2” 
               
               
                   
                 /product = “E2B_IVa2” 
               
               
                   
               
               
                 polyA_signal 
                 complement(4150 . . . 4155) 
               
               
                   
                 /note = “IVa2, E2B” 
               
               
                   
               
               
                 CDS 
                 complement(join(5257 . . . 8838, 14209 . . . 14217)) 
               
               
                   
                 /gene = “E2B” 
               
               
                   
                 /product = “E2B_polymerase” 
               
               
                   
               
               
                 gene 
                 6078 . . . 34605 
               
               
                   
                 /gene = “L5” 
               
               
                   
               
               
                 gene 
                 6078 . . . 28612 
               
               
                   
                 /gene = “L4” 
               
               
                   
               
               
                 gene 
                 6078 . . . 22658 
               
               
                   
                 /gene = “L3” 
               
               
                   
               
               
                 gene 
                 6078 . . . 18164 
               
               
                   
                 /gene = “L2” 
               
               
                   
               
               
                 gene 
                 6078 . . . 14216 
               
               
                   
                 /gene = “L1” 
               
               
                   
               
               
                 TATA_signal 
                 6078 . . . 6083 
               
               
                   
                 /note = “L” 
               
               
                   
               
               
                 prim_transcript 
                 6109 . . . 34605 
               
               
                   
                 /gene = “L5” 
               
               
                   
               
               
                 prim_transcript 
                 6109 . . . 28612 
               
               
                   
                 /gene = “L4” 
               
               
                   
               
               
                 prim_transcript 
                 6109 . . . 22658 
               
               
                   
                 /gene = “L3” 
               
               
                   
               
               
                 prim_transcript 
                 6109 . . . 18164 
               
               
                   
                 /gene = “L2” 
               
               
                   
               
               
                 prim_transcript 
                 6109 . . . 14216 
               
               
                   
                 /gene = “L1” 
               
               
                   
               
               
                 CDS 
                 join(8038 . . . 8457, 9722 . . . 9742) 
               
               
                   
                 /gene = “L1” 
               
               
                   
                 /product = “L1_13.6K” 
               
               
                   
               
               
                 CDS 
                 complement(join(8637 . . . 10640, 14209 . . . 14217)) 
               
               
                   
                 /gene = “E2B” 
               
               
                   
                 /product = “E2B_pTP” 
               
               
                   
               
               
                 gene 
                 10671 . . . 10832 
               
               
                   
                 /gene = “VAI” 
               
               
                   
               
               
                 misc_RNA 
                 10671 . . . 10832 
               
               
                   
                 /gene = “VAI” 
               
               
                   
                 /product = “VAI” 
               
               
                   
               
               
                 gene 
                 10902 . . . 11072 
               
               
                   
                 /gene = “VAII” 
               
               
                   
               
               
                 misc_RNA 
                 10902 . . . 11072 
               
               
                   
                 /gene = “VAII” 
               
               
                   
                 /product = “VAII” 
               
               
                   
               
               
                 CDS 
                 11093 . . . 12352 
               
               
                   
                 /gene = “L1” 
               
               
                   
                 /product = “L1_52K” 
               
               
                   
               
               
                 CDS 
                 12376 . . . 14157 
               
               
                   
                 /gene = “L1” 
               
               
                   
                 /product = “L1_pIIIa” 
               
               
                   
               
               
                 polyA_signal 
                 14197 . . . 14202 
               
               
                   
                 /gene = “L1” 
               
               
                   
               
               
                 CDS 
                 14254 . . . 16035 
               
               
                   
                 /gene = “L2” 
               
               
                   
                 /product = “L2_penton” 
               
               
                   
               
               
                 CDS 
                 16050 . . . 16646 
               
               
                   
                 /gene = “L2” 
               
               
                   
                 /product = “L2_pVII” 
               
               
                   
               
               
                 CDS 
                 16719 . . . 17834 
               
               
                   
                 /gene = “L2” 
               
               
                   
                 /product = “L2_V” 
               
               
                   
               
               
                 CDS 
                 17859 . . . 18104 
               
               
                   
                 /gene = “L2” 
               
               
                   
                 /product = “L2_pX” 
               
               
                   
               
               
                 polyA_signal 
                 18143 . . . 18148 
               
               
                   
                 /gene = “L2” 
               
               
                   
               
               
                 CDS 
                 18196 . . . 18951 
               
               
                   
                 /gene = “L3” 
               
               
                   
                 /product = “L3_pVI” 
               
               
                   
               
               
                 CDS 
                 19063 . . . 21945 
               
               
                   
                 /gene = “L3” 
               
               
                   
                 /product = “L3_hexon” 
               
               
                   
               
               
                 CDS 
                 21975 . . . 22604 
               
               
                   
                 /gene = “L3” 
               
               
                   
                 /product = “L3_protease” 
               
               
                   
               
               
                 polyA_signal 
                 22630 . . . 22635 
               
               
                   
                 /gene = “L3” 
               
               
                   
               
               
                 gene 
                 complement(22632 . . . 27523) 
               
               
                   
                 /gene = “E2A” 
               
               
                   
               
               
                 prim_transcript 
                 complement(22632 . . . 27494) 
               
               
                   
                 /gene = “E2A” 
               
               
                   
               
               
                 gene 
                 complement(22632 . . . 26357) 
               
               
                   
                 /gene = “E2A-L” 
               
               
                   
               
               
                 prim_transcript 
                 complement(22632 . . . 26328) 
               
               
                   
                 /gene = “E2A-L” 
               
               
                   
               
               
                 polyA_signal 
                 complement(22649 . . . 22654) 
               
               
                   
                 /note = “E2A, E2A-L” 
               
               
                   
               
               
                 CDS 
                 complement(22715 . . . 24367) 
               
               
                   
                 /gene = “E2A” 
               
               
                   
                 /note = “DBP; genus-common; DBP family” 
               
               
                   
                 /codon_start = 1 
               
               
                   
                 /product = “E2A” 
               
               
                   
               
               
                 CDS 
                 24405 . . . 26915 
               
               
                   
                 /gene = “L4” 
               
               
                   
                 /product = “L4_100k” 
               
               
                   
               
               
                 TATA_signal 
                 complement(26352 . . . 26357) 
               
               
                   
                 /gene = “E2A-L” 
               
               
                   
               
               
                 CDS 
                 join(26602 . . . 26941, 27147 . . . 27529) 
               
               
                   
                 /gene = “L4” 
               
               
                   
                 /product = “L4_33K” 
               
               
                   
               
               
                 CDS 
                 26602 . . . 27207 
               
               
                   
                 /gene = “L4” 
               
               
                   
                 /product = “L4_22K” 
               
               
                   
               
               
                 TATA_signal 
                 complement(27518 . . . 27523) 
               
               
                   
                 /note = “E2A, E2B; nominal” 
               
               
                   
               
               
                 CDS 
                 27604 . . . 28287 
               
               
                   
                 /gene = “L4” 
               
               
                   
                 /product = “L4_pVIII” 
               
               
                   
               
               
                 gene 
                 27969 . . . 32686 
               
               
                   
                 /gene = “E3B” 
               
               
                   
               
               
                 gene 
                 27969 . . . 31611 
               
               
                   
                 /gene = “E3A” 
               
               
                   
               
               
                 TATA_signal 
                 27969 . . . 27974 
               
               
                   
                 /note = “E3A, E3B” 
               
               
                   
               
               
                 prim_transcript 
                 27998 . . . 32686 
               
               
                   
                 /gene = “E3B” 
               
               
                   
               
               
                 prim_transcript 
                 27998 . . . 31611 
               
               
                   
                 /gene = “E3A” 
               
               
                   
               
               
                 CDS 
                 28288 . . . 28605 
               
               
                   
                 /gene = “E3A” 
               
               
                   
                 /product = “E3 ORF1” 
               
               
                   
               
               
                 polyA_signal 
                 28594 . . . 28599 
               
               
                   
                 /gene = “L4” 
               
               
                   
               
               
                 CDS 
                 29103 . . . 29303 
               
               
                   
                 /gene = “E3A” 
               
               
                   
                 /product = “E3 ORF2” 
               
               
                   
               
               
                 CDS 
                 29300 . . . 29797 
               
               
                   
                 /gene = “E3A” 
               
               
                   
                 /product = “E3 ORF3” 
               
               
                   
               
               
                 CDS 
                 29826 . . . 30731 
               
               
                   
                 /gene = “E3A” 
               
               
                   
                 /product = “E3 ORF4” 
               
               
                   
               
               
                 CDS 
                 30728 . . . 31579 
               
               
                   
                 /gene = “E3A” 
               
               
                   
                 /product = “E3 ORF5” 
               
               
                   
               
               
                 CDS 
                 31283 . . . 31579 
               
               
                   
                 /gene = “E3A” 
               
               
                   
                 /product = “E3 ORF6” 
               
               
                   
               
               
                 polyA_signal 
                 31578 . . . 31584 
               
               
                   
                 /gene = “E3A” 
               
               
                   
               
               
                 CDS 
                 31591 . . . 31863 
               
               
                   
                 /gene = “E3B” 
               
               
                   
                 /product = “E3 ORF7” 
               
               
                   
               
               
                 CDS 
                 31866 . . . 32264 
               
               
                   
                 /gene = “E3B” 
               
               
                   
                 /product = “E3 ORF8” 
               
               
                   
               
               
                 CDS 
                 32257 . . . 32643 
               
               
                   
                 /gene = “E3B” 
               
               
                   
                 /product = “E3 ORF9” 
               
               
                   
               
               
                 polyA_signal 
                 32659 . . . 32664 
               
               
                   
                 /gene = “E3B” 
               
               
                   
               
               
                 gene 
                 complement(&lt;32678 . . . 32838) 
               
               
                   
                 /gene = “U” 
               
               
                   
               
               
                 CDS 
                 complement(&lt;32678 . . . 32838) 
               
               
                   
                 /gene = “U” 
               
               
                   
                 /note = “exon encoding C terminus unidentified; 
               
               
                   
                 genus-common” 
               
               
                   
                 /product = “protein U” 
               
               
                   
               
               
                 CDS 
                 32849 . . . 34585 
               
               
                   
                 /gene = “L5” 
               
               
                   
                 /product = “L5_fiber” 
               
               
                   
               
               
                 polyA_signal 
                 34581 . . . 34586 
               
               
                   
                 /gene = “L5” 
               
               
                   
               
               
                 gene 
                 complement(34611 . . . 37520) 
               
               
                   
                 /gene = “E4” 
               
               
                   
               
               
                 prim_transcript 
                 complement(34611 . . . 37490) 
               
               
                   
                 /gene = “E4” 
               
               
                   
               
               
                 polyA_signal 
                 complement(34625 . . . 34630) 
               
               
                   
                 /gene = “E4” 
               
               
                   
               
               
                 CDS 
                 complement(join)34794 . . . 35069, 35781 . . . 35954)) 
               
               
                   
                 /gene = “E4” 
               
               
                   
                 /product = “E4 0RF7” 
               
               
                   
               
               
                 CDS 
                 complement(35070 . . . 35954) 
               
               
                   
                 /gene = “E4” 
               
               
                   
                 /product = “E4 ORF6” 
               
               
                   
               
               
                 CDS 
                 complement(35875 . . . 36219) 
               
               
                   
                 /gene = “E4” 
               
               
                   
                 /product = “E4 ORF4” 
               
               
                   
               
               
                 CDS 
                 complement(36235 . . . 36582) 
               
               
                   
                 /gene = “E4” 
               
               
                   
                 /product = “E4 ORF3” 
               
               
                   
               
               
                 CDS 
                 complement(36579 . . . 36971) 
               
               
                   
                 /gene = “E4” 
               
               
                   
                 /product = “E4 ORF2” 
               
               
                   
               
               
                 CDS 
                 complement(37029 . . . 37415) 
               
               
                   
                 /gene = “E4” 
               
               
                   
                 /product = “E4 ORF1” 
               
               
                   
               
               
                 TATA_signal 
                 complement(37515 . . . 37520) 
               
               
                   
                 /gene = “E4” 
               
               
                   
               
               
                 repeat_region 
                 37740 . . . 37830 
               
               
                   
                 /standard_name = “ITR” 
               
               
                   
                 /rpt_type = inverted 
               
               
                   
               
            
           
         
       
     
     In one embodiment, fragments of the sequences of SEQ ID NO: 7, 8, 9, 10 and their complementary strands, cDNA and RNA complementary thereto are provided. Suitably, fragments are at least 15 nucleotides in length, more suitably 30 nucleotides in length, more suitably 60 nucleotides in length, more suitably 120 nucleotides in length, more suitably 240, more suitably 480 nucleotides in length and encompass functional fragments, i.e., fragments which are of biological interest. For example, a functional fragment can express a desired adenoviral product or may be useful in production of recombinant viral vectors. Such fragments include the gene sequences listed above. 
     Gene products of the ChAd155 adenovirus, such as proteins, enzymes, and fragments thereof, which are encoded by the adenoviral nucleic acids described herein are provided. Such proteins include those encoded by the open reading frames identified above and the proteins encoded by the polynucleotides provided in the Sequence Listing. 
     Further ChAd155 Polynucleotides and Polypeptides 
     In some embodiments the polynucleotide of the invention comprises a polynucleotide encoding a fiber polypeptide; a penton polypeptide; a hexon polypeptide and penton polypeptide; a hexon polypeptide and fiber polypeptide; penton polypeptide and fiber polypeptide; or hexon polypeptide, penton polypeptide and fiber polypeptide of the invention; and may further comprise additional adenoviral polynucleotides, suitably ChAd155 polynucleotides. Thus, suitably the polynucleotide according to the invention comprises one or more of the following, the sequence coordinates relative to SEQ ID NO:10 provided in the previous annotation:
         (a) an adenoviral 5′-inverted terminal repeat (ITR);   (b) an adenoviral E1A region, or a fragment thereof selected from among the E1A_280R and E1A_243R regions;   (c) an adenoviral E1B or IX region, or a fragment thereof selected from among the group consisting of the E1B_19K, E1B_55K and IX regions;   (d) an adenoviral E2B region; or a fragment thereof selected from among the group consisting of the E2B_pTP, E2B_polymerase and E2B_IVa2 regions;   (e) an adenoviral L1 region, or a fragment thereof, said fragment encoding an adenoviral protein selected from the group consisting of the L1_13.6K, L1_52K and L1_pIIIa protein;   (f) an adenoviral L2 region or a L2 region comprising a polynucleotide encoding the penton protein of the invention, or a fragment thereof, said fragment encoding an adenoviral protein selected from the group consisting of the L2_penton protein, the L2_pVII protein, the L2_V protein and the L2_pX protein;   (g) an adenoviral L3 region or a L3 region comprising a polynucleotide encoding the hexon protein of the invention, or a fragment thereof, said fragment encoding an adenoviral protein selected from the group consisting of the L3_pVI protein, the L3_hexon protein and the L3_protease protein;   (h) an adenoviral E2A region;   (i) an adenoviral L4 region, or a fragment thereof said fragment encoding an adenoviral protein selected from the group consisting of the L4_100k protein, the L4_33K protein, the L4_22K protein and protein L4_VIII;   (j) an adenoviral E3 region, or a fragment thereof selected from the group consisting of E3 ORF1, E3 ORF2, E3 ORF3, E3 ORF4, E3 ORF5, E3 ORF6, E3 ORF7, E3 ORF8, and E3 ORF9;   (k) an adenoviral L5 region or a L5 region comprising a polynucleotide encoding the L5_fiber fiber polypeptide of the invention   (l) an adenoviral (such as Ad5) E4 region, or a fragment thereof selected from the group consisting of E4 ORF7, E4 ORF6, E4 ORF4, E4 ORF3, E4 ORF2, and E4 ORF1; in particular ORF6 of said E4 region;   (m) an adenoviral 3′-ITR; and/or   (n) an adenoviral VAI or VAII RNA region, preferably an adenoviral VAI or VAII RNA region from an adenovirus other than ChAd155, more preferably from Ad5.       

     Definitions 
     Suitably the polynucleotides or polypeptides of the invention are isolated. An “isolated” polynucleotide is one that is removed from its original environment. For example, a naturally-occurring polynucleotide is isolated if it is separated from some or all of the coexisting materials in the natural system. A polynucleotide is considered to be isolated if, for example, it is cloned into a vector that is not a part of its natural environment or if it is comprised within cDNA. 
     Suitably the polynucleotides of the invention are recombinant. Recombinant means that the polynucleotide is the product of at least one of cloning, restriction or ligation steps, or other procedures that result in a polynucleotide that is distinct from a polynucleotide found in nature. A recombinant adenovirus is an adenovirus comprising a recombinant polynucleotide. A recombinant vector is a vector comprising a recombinant polynucleotide. ‘A recombinant virus’ includes progeny of the original recombinant virus. ‘A recombinant vector’ includes replicates of the original recombinant vector. ‘A recombinant polynucleotide’ includes replicates of the original recombinant polynucleotide. 
     Suitably, the polypeptide sequence of the present invention contains at least one alteration with respect to a native sequence. Suitably, the polynucleotide sequences of the present invention contain at least one alteration with respect to a native sequence. For example, a polynucleotide introduced by genetic engineering techniques into a plasmid or vector derived from a different species (and often a different genus, subfamily or family) is a heterologous polynucleotide. A promoter removed from its native coding sequence and operatively linked to a coding sequence with which it is not naturally found linked is a heterologous promoter. A specific recombination site that has been cloned into a genome of a virus or viral vector, wherein the genome of the virus does not naturally contain it, is a heterologous recombination site. A heterologous nucleic acid sequence also includes a sequence naturally found in an adenoviral genome, but located at a non-native position within the adenoviral vector. 
     Typically, “heterologous” means derived from a genotypically distinct entity from that of the rest of the entity to which it is being compared. A heterologous nucleic acid sequence refers to any nucleic acid sequence that is not isolated from, derived from, or based upon a naturally occurring nucleic acid sequence of the adenoviral vector. “Naturally occurring” means a sequence found in nature and not synthetically prepared or modified. A sequence is “derived” from a source when it is isolated from a source but modified (e.g., by deletion, substitution (mutation), insertion, or other modification), suitably so as not to disrupt the normal function of the source gene. 
     A “functional derivative” of a polypeptide suitably refers to a modified version of a polypeptide, e.g. wherein one or more amino acids of the polypeptide may be deleted, inserted, modified and/or substituted. A derivative of an unmodified adenoviral capsid protein is considered functional if, for example:
         (a) an adenovirus comprising the derivative capsid protein within its capsid retains substantially the same or a lower seroprevalence compared to an adenovirus comprising the unmodified capsid protein and/or   (b) an adenovirus comprising the derivative capsid protein within its capsid retains substantially the same or a higher host cell infectivity compared to an adenovirus comprising the unmodified capsid protein and/or   (c) an adenovirus comprising the derivative capsid protein within its capsid retains substantially the same or a higher immunogenicity compared to an adenovirus comprising the unmodified capsid protein and or   (d) an adenovirus comprising the derivative capsid protein within its capsid retains substantially the same or a higher level of transgene productivity compared to an adenovirus comprising the unmodified capsid protein.       

     Properties (a)-(d) above may suitably be measured using the methods described in the Examples section below. 
     Suitably, the polypeptide, vector or recombinant adenovirus has a low seroprevalence in a human population. “Low seroprevalence” may mean having a reduced pre-existing neutralizing antibody level as compared to human adenovirus 5 (Ad5). Similarly or alternatively, “low seroprevalence” may mean less than about 20% seroprevalence, less than about 15% seroprevalence, less than about 10% seroprevalence, less than about 5% seroprevalence, less than about 4% seroprevalence, less than about 3% seroprevalence, less than about 2% seroprevalence, less than about 1% seroprevalence or no detectable seroprevalence. Seroprevalence can be measured as the percentage of individuals having a clinically relevant neutralizing titre (defined as a 50% neutralisation titer &gt;200) using methods as described in Aste-Amézaga et al., Hum. Gene Ther. (2004) 15(3):293-304. 
     The terms polypeptide, peptide and protein are used interchangeably herein. 
     The term “simian” is typically meant to encompass nonhuman primates, for example Old World monkeys, New World monkeys, apes and gibbons. In particular, simian may refer to nonhuman apes such as chimpanzees ( Pan troglodyte ), bonobos ( Pan paniscus ) and gorillas (genus  Gorilla ). Non-ape simians may include rhesus macaques ( Macaca mulatta ) 
     Sequence Comparison 
     For the purposes of comparing two closely-related polynucleotide or polypeptide sequences, the “% identity” between a first sequence and a second sequence may be calculated using an alignment program, such as BLAST® (available at blast.ncbi.nlm.nih.gov, last accessed 9 Mar. 2015) using standard settings. The % identity is the number of identical residues divided by the number of residues in the reference sequence, multiplied by 100. The identity figures referred to above and in the claims are percentages calculated by this methodology. An alternative definition of % identity is the number of identical residues divided by the number of aligned residues, multiplied by 100. Alternative methods include using a gapped method in which gaps in the alignment, for example deletions in one sequence relative to the other sequence, are accounted for in a gap score or a gap cost in the scoring parameter. For more information, see the BLAST® fact sheet available at ftp.ncbi.nlm.nih.gov/pub/factsheets/HowTo_BLASTGuide.pdf, last accessed on 9 Mar. 2015. 
     Sequences that preserve the functionality of the polynucleotide or a polypeptide encoded thereby are likely to be more closely identical. Polypeptide or polynucleotide sequences are said to be the same as or identical to other polypeptide or polynucleotide sequences, if they share 100% sequence identity over their entire length. 
     A “difference” between sequences refers to an insertion, deletion or substitution of a single amino acid residue in a position of the second sequence, compared to the first sequence. Two polypeptide sequences can contain one, two or more such amino acid differences. Insertions, deletions or substitutions in a second sequence which is otherwise identical (100% sequence identity) to a first sequence result in reduced percent sequence identity. For example, if the identical sequences are 9 amino acid residues long, one substitution in the second sequence results in a sequence identity of 88.9%. If the identical sequences are 17 amino acid residues long, two substitutions in the second sequence results in a sequence identity of 88.2%. If the identical sequences are 7 amino acid residues long, three substitutions in the second sequence results in a sequence identity of 57.1%. If first and second polypeptide sequences are 9 amino acid residues long and share 6 identical residues, the first and second polypeptide sequences share greater than 66% identity (the first and second polypeptide sequences share 66.7% identity). If first and second polypeptide sequences are 17 amino acid residues long and share 16 identical residues, the first and second polypeptide sequences share greater than 94% identity (the first and second polypeptide sequences share 94.1% identity). If first and second polypeptide sequences are 7 amino acid residues long and share 3 identical residues, the first and second polypeptide sequences share greater than 42% identity (the first and second polypeptide sequences share 42.9% identity). 
     Alternatively, for the purposes of comparing a first, reference polypeptide sequence to a second, comparison polypeptide sequence, the number of additions, substitutions and/or deletions made to the first sequence to produce the second sequence may be ascertained. An addition is the addition of one amino acid residue into the sequence of the first polypeptide (including addition at either terminus of the first polypeptide). A substitution is the substitution of one amino acid residue in the sequence of the first polypeptide with one different amino acid residue. A deletion is the deletion of one amino acid residue from the sequence of the first polypeptide (including deletion at either terminus of the first polypeptide). 
     For the purposes of comparing a first, reference polynucleotide sequence to a second, comparison polynucleotide sequence, the number of additions, substitutions and/or deletions made to the first sequence to produce the second sequence may be ascertained. An addition is the addition of one nucleotide residue into the sequence of the first polynucleotide (including addition at either terminus of the first polynucleotide). A substitution is the substitution of one nucleotide residue in the sequence of the first polynucleotide with one different nucleotide residue. A deletion is the deletion of one nucleotide residue from the sequence of the first polynucleotide (including deletion at either terminus of the first polynucleotide). 
     Suitably substitutions in the sequences of the present invention may be conservative substitutions. A conservative substitution comprises the substitution of an amino acid with another amino acid having a chemical property similar to the amino acid that is substituted (see, for example, Stryer et al,  Biochemistry,  5 th  Edition 2002, pages 44-49). Preferably, the conservative substitution is a substitution selected from the group consisting of: (i) a substitution of a basic amino acid with another, different basic amino acid; (ii) a substitution of an acidic amino acid with another, different acidic amino acid; (iii) a substitution of an aromatic amino acid with another, different aromatic amino acid; (iv) a substitution of a non-polar, aliphatic amino acid with another, different non-polar, aliphatic amino acid; and (v) a substitution of a polar, uncharged amino acid with another, different polar, uncharged amino acid. A basic amino acid is preferably selected from the group consisting of arginine, histidine, and lysine. An acidic amino acid is preferably aspartate or glutamate. An aromatic amino acid is preferably selected from the group consisting of phenylalanine, tyrosine and tryptophane. A non-polar, aliphatic amino acid is preferably selected from the group consisting of glycine, alanine, valine, leucine, methionine and isoleucine. A polar, uncharged amino acid is preferably selected from the group consisting of serine, threonine, cysteine, proline, asparagine and glutamine. In contrast to a conservative amino acid substitution, a non-conservative amino acid substitution is the exchange of one amino acid with any amino acid that does not fall under the above-outlined conservative substitutions (i) through (v). 
     Vectors and Recombinant Adenovirus 
     The ChAd155 sequences of the invention are useful as therapeutic agents and in construction of a variety of vector systems, recombinant adenovirus and host cells. Suitably the term “vector” refers to a nucleic acid that has been substantially altered (e.g., a gene or functional region that has been deleted and/or inactivated) relative to a wild type sequence and/or incorporates a heterologous sequence, i.e.,nucleic acid obtained from a different source (also called an “insert”), and replicating and/or expressing the inserted polynucleotide sequence, when introduced into a cell (e.g., a host cell). For example, the insert may be all or part of the ChAd155 sequences described herein. In addition or alternatively, a ChAd155 vector may be a ChAd155 adenovirus comprising one or more deletions or inactivations of viral genes, such as E1 or other viral gene or functional region described herein. Such a ChAd155, which may or may not comprise a heterologous sequence, is often called a “backbone” and may be used as is or as a starting point for additional modifications to the vector. 
     A vector may be any suitable nucleic acid molecule including naked DNA, a plasmid, a virus, a cosmid, phage vector such as lambda vector, an artificial chromosome such as a BAC (bacterial artificial chromosome), or an episome. Alternatively, a vector may be a transcription and/or expression unit for cell-free in vitro transcription or expression, such as a T7-compatible system. The vectors may be used alone or in combination with other adenoviral sequences or fragments, or in combination with elements from non-adenoviral sequences. The ChAd155 sequences are also useful in antisense delivery vectors, gene therapy vectors, or vaccine vectors. Thus, further provided are gene delivery vectors, and host cells which contain the ChAd155 sequences. 
     The term “replication-competent” adenovirus refers to an adenovirus which can replicate in a host cell in the absence of any recombinant helper proteins comprised in the cell. Suitably, a “replication-competent” adenovirus comprises the following intact or functional essential early genes: E1A, E1B, E2A, E2B, E3 and E4. Wild type adenoviruses isolated from a particular animal will be replication competent in that animal. 
     The term “replication-incompetent” or “replication-defective” adenovirus refers to an adenovirus which is incapable of replication because it has been engineered to comprise at least a functional deletion (or “loss-of-function” mutation), i.e. a deletion or mutation which impairs the function of a gene without removing it entirely, e.g. introduction of artificial stop codons, deletion or mutation of active sites or interaction domains, mutation or deletion of a regulatory sequence of a gene etc, or a complete removal of a gene encoding a gene product that is essential for viral replication, such as one or more of the adenoviral genes selected from E1A, E1B, E2A, E2B, E3 and E4 (such as E3 ORF1, E3 ORF2, E3 ORF3, E3 ORF4, E3 ORF5, E3 ORF6, E3 ORF7, E3 ORF8, E3 ORF9, E4 ORF7, E4 ORF6, E4 ORF4, E4 ORF3, E4 ORF2 and/or E4 ORF1). Particularly suitably E1 and optionally E3 and/or E4 are deleted. If deleted, the aforementioned deleted gene region will suitably not be considered in the alignment when determining % identity with respect to another sequence. 
     The present invention provides vectors such as recombinant adenovirus that deliver a protein, suitably a heterologous protein, to cells, either for therapeutic or vaccine purposes. A vector may include any genetic element including naked DNA, a phage, transposon, cosmid, episome, plasmid, or a virus. Such vectors contain DNA of ChAd155 as disclosed herein and a minigene. By “minigene” (or “expression cassette”) is meant the combination of a selected heterologous gene (transgene) and the other regulatory elements necessary to drive translation, transcription and/or expression of the gene product in a host cell. 
     Typically, a ChAd155-derived adenoviral vector is designed such that the minigene is located in a nucleic acid molecule which contains other adenoviral sequences in the region native to a selected adenoviral gene. The minigene may be inserted into an existing gene region to disrupt the function of that region, if desired. Alternatively, the minigene may be inserted into the site of a partially or fully deleted adenoviral gene. For example, the minigene may be located in the site of a mutation, insertion or deletion which renders non-functional at least one gene of a genomic region selected from the group consisting of E1A, E1B, E2A, E2B, E3 and E4. The term “renders non-functional” means that a sufficient amount of the gene region is removed or otherwise disrupted, so that the gene region is no longer capable of producing functional products of gene expression. If desired, the entire gene region may be removed (and suitably replaced with the minigene). 
     For example, for a production vector useful for generation of a recombinant virus, the vector may contain the minigene and either the 5′ end of the adenoviral genome or the 3′ end of the adenoviral genome, or both the 5′ and 3′ ends of the adenoviral genome. The 5′ end of the adenoviral genome contains the 5′ cis-elements necessary for packaging and replication; i.e., the 5′ ITR sequences (which function as origins of replication) and the native 5′ packaging enhancer domains (that contain sequences necessary for packaging linear Ad genomes and enhancer elements for the E1 promoter). The 3′ end of the adenoviral genome includes the 3′ cis-elements (including the ITRs) necessary for packaging and encapsidation. Suitably, a recombinant adenovirus contains both 5′ and 3′ adenoviral cis-elements and the minigene (suitably containing a transgene) is located between the 5′ and 3′ adenoviral sequences. A ChAd155-based adenoviral vector may also contain additional adenoviral sequences. 
     Suitably, ChAd155-based vectors contain one or more adenoviral elements derived from the adenoviral ChAd155 genome of the invention. In one embodiment, the vectors contain adenoviral ITRs from ChAd155 and additional adenoviral sequences from the same adenoviral serotype. In another embodiment, the vectors contain adenoviral sequences that are derived from a different adenoviral serotype than that which provides the ITRs. 
     As defined herein, a pseudotyped adenovirus refers to an adenovirus in which the capsid proteins of the adenovirus are from a different adenovirus than the adenovirus which provides the ITRs. 
     Further, chimeric or hybrid adenoviruses may be constructed using the adenoviruses described herein using techniques known to those of skill in the art (e.g., U.S. Pat. No. 7,291,498). 
     ITRs and any other adenoviral sequences present in the vector of the present invention may be obtained from many sources. A variety of adenovirus strains are available from the American Type Culture Collection, Manassas, Va., or available by request from a variety of commercial and institutional sources. Further, the sequences of many such strains are available from a variety of databases including, e.g., PubMed and GenBank. Homologous adenovirus vectors prepared from other chimp or from human adenoviruses are described in the published literature (for example, U.S. Pat. No. 5,240,846). The DNA sequences of a number of adenovirus types are available from GenBank, including type Ad5 (GenBank Accession Number M73370). The adenovirus sequences may be obtained from any known adenovirus serotype, such as serotypes 2, 3, 4, 7, 12 and 40, and further including any of the presently identified human types. Similarly adenoviruses known to infect nonhuman animals (e.g., simians) may also be employed in the vector constructs of this invention (e.g., U.S. Pat. No. 6,083,716). The viral sequences, helper viruses (if needed), and recombinant viral particles, and other vector components and sequences employed in the construction of the vectors described herein may be obtained as described below. 
     Sequence, Vector and Adenovirus Production 
     The sequences of the invention may be produced by any suitable means, including recombinant production, chemical synthesis, or other synthetic means. Suitable production techniques are well known to those of skill in the art. Alternatively, peptides can also be synthesized by well known solid phase peptide synthesis methods. 
     The adenoviral plasmids (or other vectors) may be used to produce adenoviral vectors. In one embodiment, the adenoviral vectors are adenoviral particles which are replication-incompetent. In one embodiment, the adenoviral particles are rendered replication-incompetent by deletions in the E1A and/or E1B genes. Alternatively, the adenoviruses are rendered replication-incompetent by another means, optionally while retaining the E1A and/or E1B genes. Similarly, in some embodiments, reduction of an immune response to the vector may be accomplished by deletions in the E2B and/or DNA polymerase genes. The adenoviral vectors can also contain other mutations to the adenoviral genome, e.g., temperature-sensitive mutations or deletions in other genes. In other embodiments, it is desirable to retain an intact E1A and/or E1B region in the adenoviral vectors. Such an intact E1 region may be located in its native location in the adenoviral genome or placed in the site of a deletion in the native adenoviral genome (e.g., in the E3 region). 
     In the construction of adenovirus vectors for delivery of a gene to a mammalian (such as human) cell, a range of modified adenovirus nucleic acid sequences can be employed in the vectors. For example, all or a portion of the adenovirus delayed early gene E3 may be eliminated from the adenovirus sequence which forms a part of the recombinant virus. The function of E3 is believed to be irrelevant to the function and production of the recombinant virus particle. Adenovirus vectors may also be constructed having a deletion of at least the ORF6 region of the E4 gene, and more desirably because of the redundancy in the function of this region, the entire E4 region. Still another vector of the invention contains a deletion in the delayed early gene E2A. Deletions may also be made in any of the late genes L1 to L5 of the adenovirus genome. Similarly, deletions in the intermediate genes IX and IVa2 may be useful for some purposes. Other deletions may be made in the other structural or non-structural adenovirus genes. The above discussed deletions may be used individually, i.e., an adenovirus sequence for use as described herein may contain deletions in only a single region. Alternatively, deletions of entire genes or portions thereof effective to destroy their biological activity may be used in any combination. For example, in one exemplary vector, the adenovirus sequence may have deletions of the E1 genes and the E4 gene, or of the E1, E2A and E3 genes, or of the E1 and E3 genes, or of E1, E2A and E4 genes, with or without deletion of E3, and so on. Any one or more of the E genes may suitably be replaced with an E gene (or one or more E gene open reading frames) sourced from a different strain of adenovirus. Particularly suitably the ChAd155 E1 and E3 genes are deleted and the ChAd155E4 gene is replaced with E4Ad5orf6. As discussed above, such deletions and/or substitutions may be used in combination with other mutations, such as temperature-sensitive mutations, to achieve a desired result. 
     An adenoviral vector lacking one or more essential adenoviral sequences (e.g., E1A, E1B, E2A, E2B, E4 ORF6, L1, L2, L3, L4 and L5) may be cultured in the presence of the missing adenoviral gene products which are required for viral infectivity and propagation of an adenoviral particle. These helper functions may be provided by culturing the adenoviral vector in the presence of one or more helper constructs (e.g., a plasmid or virus) or a packaging host cell. 
     Complementation of Replication-Incompetent Vectors 
     To generate recombinant adenoviruses deleted in any of the genes described above, the function of the deleted gene region, if essential to the replication and infectivity of the virus, must be supplied to the recombinant virus by a helper virus or cell line, i.e., a complementation or packaging cell line. 
     Helper Viruses 
     Depending upon the adenovirus gene content of the viral vectors employed to carry the minigene, a helper adenovirus or non-replicating virus fragment may be used to provide sufficient adenovirus gene sequences necessary to produce an infective recombinant viral particle containing the minigene. Useful helper viruses contain selected adenovirus gene sequences not present in the adenovirus vector construct and/or not expressed by the packaging cell line in which the vector is transfected. In one embodiment, the helper virus is replication-defective and contains adenovirus genes in addition, suitably, to one or more of the sequences described herein. Such a helper virus is suitably used in combination with an E1 expressing (and optionally additionally E3 expressing) cell line. 
     A helper virus may optionally contain a reporter gene. A number of such reporter genes are known to the art as well as described herein. The presence of a reporter gene on the helper virus which is different from the transgene on the adenovirus vector allows both the adenoviral vector and the helper virus to be independently monitored. This reporter is used to enable separation between the resulting recombinant virus and the helper virus upon purification. 
     Complementation Cell Lines 
     In many circumstances, a cell line expressing the one or more missing genes which are essential to the replication and infectivity of the virus, such as human E1, can be used to transcomplement a chimp adenoviral vector. This is particularly advantageous because, due to the diversity between the chimp adenovirus sequences of the invention and the human adenovirus sequences found in currently available packaging cells, the use of the current human E1-containing cells prevents the generation of replication-competent adenoviruses during the replication and production process. 
     Alternatively, if desired, one may utilize the sequences provided herein to generate a packaging cell or cell line that expresses, at a minimum, the E1 gene from ChAd155 under the transcriptional control of a promoter for expression in a selected parent cell line. Inducible or constitutive promoters may be employed for this purpose. Examples of such promoters are described in detail elsewhere in this document. A parent cell is selected for the generation of a novel cell line expressing any desired ChAd155 gene. Without limitation, such a parent cell line may be HeLa [ATCC Accession No. CCL 2], A549 [ATCC Accession No. CCL 185], HEK 293, KB [CCL 17], Detroit [e.g., Detroit 510, CCL 72] and WI-38 [CCL 75] cells, among others. These cell lines are all available from the American Type Culture Collection, 10801 University Boulevard, Manassas, Va. 20110-2209. 
     Such E1-expressing cell lines are useful in the generation of recombinant adenovirus E1 deleted vectors. Additionally, or alternatively, cell lines that express one or more adenoviral gene products, e.g., E1A, E1B, E2A, E3 and/or E4, can be constructed using essentially the same procedures as used in the generation of recombinant viral vectors. Such cell lines can be utilised to transcomplement adenovirus vectors deleted in the essential genes that encode those products, or to provide helper functions necessary for packaging of a helper-dependent virus (e.g., adeno-associated virus). The preparation of a host cell involves techniques such as assembly of selected DNA sequences. 
     In another alternative, the essential adenoviral gene products are provided in trans by the adenoviral vector and/or helper virus. In such an instance, a suitable host cell can be selected from any biological organism, including prokaryotic (e.g., bacterial) cells, and eukaryotic cells, including, insect cells, yeast cells and mammalian cells. 
     Host cells may be selected from among any mammalian species, including, without limitation, cells such as A549, WEHI, 3T3, 1011/2, HEK 293 cells or Per.C6 (both of which express functional adenoviral El) [Fallaux, 1998], Saos, C2C12, L cells, HT1080, HepG2 and primary fibroblast, hepatocyte and myoblast cells derived from mammals including human, monkey, mouse, rat, rabbit, and hamster. 
     A particularly suitable complementation cell line is the Procell92 cell line. The Procell92 cell line is based on HEK 293 cells which express adenoviral E1 genes, transfected with the Tet repressor under control of the human phosphoglycerate kinase-1 (PGK) promoter, and the G418-resistance gene (Vitelli et al.  PLOS One  (2013) 8(e55435):1-9). Procell92.S is adapted for growth in suspension conditions and is useful for producing adenoviral vectors expressing toxic proteins (www.okairos.com/e/inners.php?m=00084, last accessed 13 Apr. 2015). 
     Assembly of a Viral Particle and Transfection of a Cell Line 
     Generally, when delivering the vector comprising the minigene by transfection, the vector is delivered in an amount from about 5 μg to about 100 μg DNA, and preferably about 10 to about 50 μg DNA to about 1×10 4  cells to about 1×10 13  cells, and preferably about 10 5  cells. 
     However, the relative amounts of vector DNA to host cells may be adjusted, taking into consideration such factors as the selected vector, the delivery method and the host cells selected. 
     Introduction into the host cell of the vector may be achieved by any means known in the art, including transfection, and infection. One or more of the adenoviral genes may be stably integrated into the genome of the host cell, stably expressed as episomes, or expressed transiently. The gene products may all be expressed transiently, on an episome or stably integrated, or some of the gene products may be expressed stably while others are expressed transiently. 
     Introduction of vectors into the host cell may also be accomplished using techniques known to the skilled person. Suitably, standard transfection techniques are used, e.g., CaPC transfection or electroporation. 
     Assembly of the selected DNA sequences of the adenovirus (as well as the transgene and other vector elements) into various intermediate plasmids, and the use of the plasmids and vectors to produce a recombinant viral particle are all achieved using conventional techniques. Such techniques include conventional cloning techniques of cDNA, use of overlapping oligonucleotide sequences of the adenovirus genomes, polymerase chain reaction, and any suitable method which provides the desired nucleotide sequence. Standard transfection and co-transfection techniques are employed, e.g., CaPC precipitation techniques. Other conventional methods employed include homologous recombination of the viral genomes, plaquing of viruses in agar overlay, methods of measuring signal generation, and the like. 
     For example, following the construction and assembly of the desired minigene-containing viral vector, the vector is transfected in vitro in the presence of a helper virus into the packaging cell line. Homologous recombination occurs between the helper and the vector sequences, which permits the adenovirus-transgene sequences in the vector to be replicated and packaged into virion capsids, resulting in the recombinant viral vector particles. The resulting recombinant adenoviruses are useful in transferring a selected transgene to a selected cell. In in vivo experiments with the recombinant virus grown in the packaging cell lines, the E1-deleted recombinant adenoviral vectors of the invention demonstrate utility in transferring a transgene to a non-simian mammal, preferably a human, cell. 
     Transgenes 
     The transgene is a nucleic acid sequence, heterologous to the vector sequences flanking the transgene, which encodes a protein of interest. The nucleic acid coding sequence is operatively linked to regulatory components in a manner which permits transgene transcription, translation, and/or expression in a host cell. 
     The composition of the transgene sequence will depend upon the use to which the resulting vector will be put. For example, the transgene may be a therapeutic transgene or an immunogenic transgene. Alternatively, a transgene sequence may include a reporter sequence, which upon expression produces a detectable signal. Such reporter sequences include, without limitation, DNA sequences encoding β-lactamase, β-galactosidase (LacZ), alkaline phosphatase, thymidine kinase, green fluorescent protein (GFP), chloramphenicol acetyltransferase (CAT), luciferase, membrane bound proteins including, for example, CD2, CD4, CD8, the influenza hemagglutinin protein, and others well known in the art, to which high affinity antibodies directed thereto exist or can be produced by conventional means, and fusion proteins comprising a membrane bound protein appropriately fused to an antigen tag domain from, among others, hemagglutinin or Myc. These coding sequences, when associated with regulatory elements which drive their expression, provide signals detectable by conventional means, including enzymatic, radiographic, colorimetric, fluorescence or other spectrographic assays, fluorescent activating cell sorting assays and immunological assays, including enzyme linked immunosorbent assay (ELISA), radioimmunoassay (RIA) and immunohistochemistry. 
     In one embodiment, the transgene is a non-marker sequence encoding a product which is useful in biology and medicine, such as a therapeutic transgene or an immunogenic transgene such as proteins, RNA, enzymes, or catalytic RNAs. Desirable RNA molecules include tRNA, dsRNA, ribosomal RNA, catalytic RNAs, and antisense RNAs. One example of a useful RNA sequence is a sequence which extinguishes expression of a targeted nucleic acid sequence in the treated animal. 
     The transgene may be used for treatment, e.g., of genetic deficiencies, as a cancer therapeutic or vaccine, for induction of an immune response, and/or for prophylactic vaccine purposes. As used herein, induction of an immune response refers to the ability of a protein to induce a T cell and/or a humoral immune response to the protein. 
     Accordingly, in one embodiment the present invention provides a recombinant vector according to the present invention comprising an expression cassette comprising an immunogenic transgene derived from a pathogen. In certain embodiments the pathogen is a respiratory virus. Thus, the present invention provides a recombinant ChAd155-derived adenoviral vector comprising an expression cassette comprising an immunogenic transgene derived from human respiratory syncytial virus (RSV). In one embodiment the recombinant ChAd155-derived adenoviral vector of the present invention comprises an RSV F antigen and RSV M and N antigens. More specifically, the nucleic acid encodes an RSV FΔTM antigen (fusion (F) protein deleted of the transmembrane and cytoplasmic regions), and RSV M2-1 (transcription anti-termination) and N (nucleocapsid) antigens. In certain embodiments, a recombinant vector comprises a nucleic acid sequence (for example within an expression cassette) which encodes a sequence according to SEQ ID NO: 37. In one embodiment, the recombinant vector consists essentially of a polynucleotide having a sequence according to SEQ IS NO: 11. 
     Regulatory Elements 
     In addition to the transgene the vector also includes conventional control elements which are operably linked to the transgene in a manner that permits its transcription, translation and/or expression in a cell transfected with the plasmid vector or infected with the virus produced by the invention. As used herein, “operably linked” sequences include both expression control sequences that are contiguous with the gene of interest and expression control sequences that act in trans or at a distance to control the gene of interest. 
     Expression control sequences include appropriate transcription initiation, termination, promoter and enhancer sequences; efficient RNA processing signals such as splicing and polyadenylation (poly A) signals including rabbit beta-globin polyA; sequences that stabilize cytoplasmic mRNA; sequences that enhance translation efficiency (e.g., Kozak consensus sequence); sequences that enhance protein stability; and when desired, sequences that enhance secretion of the encoded product. Among other sequences, chimeric introns may be used. 
     In some embodiments, the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element (WPRE) (Zuffrey et al. (1999) J Virol; 73(4):2886-9) may be operably linked to the transgene. An exemplary WPRE is provided in SEQ ID NO: 26. 
     A “promoter” is a nucleotide sequence that permits binding of RNA polymerase and directs the transcription of a gene. Typically, a promoter is located in the 5′ non-coding region of a gene, proximal to the transcriptional start site of the gene. Sequence elements within promoters that function in the initiation of transcription are often characterized by consensus nucleotide sequences. Examples of promoters include, but are not limited to, promoters from bacteria, yeast, plants, viruses, and mammals (including humans). A great number of expression control sequences, including promoters which are internal, native, constitutive, inducible and/or tissue-specific, are known in the art and may be utilized. 
     Examples of constitutive promoters include, without limitation, the TBG promoter, the retroviral Rous sarcoma virus LTR promoter (optionally with the enhancer), the cytomegalovirus (CMV) promoter (optionally with the CMV enhancer, see, e.g., Boshart et al, Cell, 41:521-530 (1985)), the CASI promoter, the SV40 promoter, the dihydrofolate reductase promoter, the β-actin promoter, the phosphoglycerol kinase (PGK) promoter, and the EF1a promoter (Invitrogen). 
     In some embodiments, the promoter is a CASI promoter (see, for example, WO2012/115980). The CASI promoter is a synthetic promoter which contains a portion of the CMV enhancer, a portion of the chicken beta-actin promoter, and a portion of the UBC enhancer. In some embodiments, the CASI promoter can include a nucleic acid sequence having at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or more, sequence identity to SEQ ID NO: 12. In some embodiments, the promoter comprises or consists of a nucleic acid sequence of SEQ ID NO: 12. 
     Inducible promoters allow regulation of gene expression and can be regulated by exogenously supplied compounds, environmental factors such as temperature, or the presence of a specific physiological state, e.g., acute phase, a particular differentiation state of the cell, or in replicating cells only. Inducible promoters and inducible systems are available from a variety of commercial sources, including, without limitation, Invitrogen, Clontech and Ariad. Many other systems have been described and can be readily selected by one of skill in the art. For example, inducible promoters include the zinc-inducible sheep metallothionine (MT) promoter and the dexamethasone (Dex)-inducible mouse mammary tumor virus (MMTV) promoter. Other inducible systems include the T7 polymerase promoter system (WO 98/10088); the ecdysone insect promoter (No et al, Proc. Natl. Acad. Sci. USA, 93:3346-3351 (1996)), the tetracycline-repressible system (Gossen et al, Proc. Natl. Acad. Sci. USA, 89:5547-5551 (1992)), the tetracycline-inducible system (Gossen et al, Science, 378:1766-1769 (1995), see also Harvey et al, Curr. Opin. Chem. Biol, 2:512-518 (1998)). Other systems include the FK506 dimer, VP16 or p65 using castradiol, diphenol murislerone, the RU486-inducible system (Wang et al, Nat. Biotech., 15:239-243 (1997) and Wang et al, Gene Ther., 4:432-441 (1997)) and the rapamycin-inducible system (Magari et al, J. Clin. Invest., 100:2865-2872 (1997)). The effectiveness of some inducible promoters increases over time. In such cases one can enhance the effectiveness of such systems by inserting multiple repressors in tandem, e.g., TetR linked to a TetR by an IRES. 
     In another embodiment, the native promoter for the transgene will be used. The native promoter may be preferred when it is desired that expression of the transgene should mimic the native expression. The native promoter may be used when expression of the transgene must be regulated temporally or developmentally, or in a tissue-specific manner, or in response to specific transcriptional stimuli. In a further embodiment, other native expression control elements, such as enhancer elements, polyadenylation sites or Kozak consensus sequences may also be used to mimic the native expression. 
     The transgene may be operably linked to a tissue-specific promoter. For instance, if expression in skeletal muscle is desired, a promoter active in muscle should be used. These include the promoters from genes encoding skeletal β-actin, myosin light chain 2A, dystrophin, muscle creatine kinase, as well as synthetic muscle promoters with activities higher than naturally occurring promoters (see Li et al, Nat. Biotech., 17:241-245 (1999)). Examples of promoters that are tissue-specific are known for liver (albumin, Miyatake et al, J. Virol, 71:5124-32 (1997); hepatitis B virus core promoter, Sandig et al, Gene Ther., 3:1002-9 (1996); alpha-fetoprotein (AFP), Arbuthnot et al., Hum. Gene Ther., 7: 1503-14 (1996)), bone osteocalcin (Stein et al, Mol. Biol. Rep., 24:185-96 (1997)); bone sialoprotein (Chen et al., J. Bone Miner. Res., 11:654-64 (1996)), lymphocytes (CD2, Hansal et al, J. Immunol, 161:1063-8 (1998); immunoglobulin heavy chain; T cell receptor chain), neuronal such as neuron-specific enolase (NSE) promoter (Andersen et al, Cell. Mol. Neurobiol, 13:503-15 (1993)), neurofilament light-chain gene (Piccioli et al, Proc. Natl. Acad. Sci. USA, 88:5611-5 (1991)), and the neuron-specific vgf gene (Piccioli et al, Neuron, 15:373-84 (1995)), among others. 
     Optionally, vectors carrying transgenes encoding therapeutically useful or immunogenic products may also include selectable markers or reporter genes which may include sequences encoding geneticin, hygromicin or purimycin resistance, among others. Such selectable reporters or marker genes (preferably located outside the viral genome to be packaged into a viral particle) can be used to signal the presence of the plasmids in bacterial cells, such as ampicillin resistance. Other components of the vector may include an origin of replication. 
     These vectors are generated using the techniques and sequences provided herein, in conjunction with techniques known to those of skill in the art. Such techniques include conventional cloning techniques of cDNA such as those described in texts, use of overlapping oligonucleotide sequences of the adenovirus genomes, polymerase chain reaction, and any suitable method which provides the desired nucleotide sequence. 
     Therapeutics and Prophylaxis 
     The recombinant ChAd155-based vectors are useful for gene transfer to a human or non-simian mammal in vitro, ex vivo, and in vivo. 
     The recombinant adenovirus vectors described herein can be used as expression vectors for the production of the products encoded by the heterologous transgenes in vitro. For example, the recombinant replication-incompetent adenovirus containing a transgene may be transfected into a complementation cell line as described above. 
     A ChAd155-derived recombinant adenoviral vector provides an efficient gene transfer vehicle that can deliver a selected transgene to a selected host cell in vivo or ex vivo even where the organism has neutralizing antibodies to one or more adenovirus serotypes. In one embodiment, the vector and the cells are mixed ex vivo; the infected cells are cultured using conventional methodologies; and the transduced cells are re-infused into the patient. These techniques are particularly well suited to gene delivery for therapeutic purposes and for immunisation, including inducing protective immunity. 
     Immunogenic Transgenes 
     The recombinant ChAd155 vectors may also be as administered in immunogenic compositions. An immunogenic composition as described herein is a composition comprising one or more recombinant ChAd155 vector capable of inducing an immune response, for example a humoral (e.g., antibody) and/or cell-mediated (e.g., a cytotoxic T cell) response, against a transgene product delivered by the vector following delivery to a mammal, suitably a human. A recombinant adenovirus may comprise (suitably in any of its gene deletions) a gene encoding a desired immunogen and may therefore be used in a vaccine. The recombinant adenoviruses can be used as prophylactic or therapeutic vaccines against any pathogen for which the antigen(s) crucial for induction of an immune response and able to limit the spread of the pathogen has been identified and for which the cDNA is available. 
     Accordingly, in one embodiment the present invention provides the use of a recombinant adenovirus according to the present invention in the treatment of disease cause by a pathogen. In one embodiment, such treatment is prophylaxis. In one embodiment, the present invention provides the use of a recombinant adenovirus in the generation of an immune response against a pathogen. In certain embodiments the pathogen is a respiratory virus. Thus, the present invention provides the use of a recombinant ChAd155-derived adenoviral vector comprising an expression cassette comprising an immunogenic transgene derived from human respiratory syncytial virus (RSV) in the treatment or prophylaxis of RSV infection. In one embodiment the recombinant ChAd155-derived adenoviral vector of the present invention comprises an RSV F antigen and RSV M and N antigens. More specifically, the nucleic acid encodes an RSV FΔTM antigen (fusion (F) protein deleted of the transmembrane and cytoplasmic regions), and RSV M2-1 (transcription anti-termination) and N (nucleocapsid) antigens. Particularly, the transgene encodes an RSV antigen as set out in SEQ ID NO: 37. 
     In further embodiments, the present invention provides the use of a recombinant adenovirus according to the present invention in the manufacture of a medicament for the generation of an immune response against a pathogen. Thus, the present invention provides the use of a recombinant ChAd155-derived adenoviral vector comprising an expression cassette comprising an immunogenic transgene derived from human respiratory syncytial virus (RSV) in the manufacture of a medicament for the treatment or prophylaxis of RSV infection. More specifically, the transgene encodes an RSV FΔTM antigen (fusion (F) protein deleted of the transmembrane and cytoplasmic regions), and RSV M2-1 (transcription anti-termination) and N (nucleocapsid) antigens. Particularly, the transgene encodes an RSV antigen as set out in SEQ ID NO: 37, for example, in one embodiment the trangene comprises a polynucleotide of SEQ ID NO: 11. 
     In one embodiment the present invention provides a method of treatment or prevention of a disease cause by a pathogen, comprising the administration of an effective amount of a recombinant adenovirus according to the present invention, for example a ChAd155-derived adenovirus, comprising an expression cassette comprising an immunogenic transgene derived from the pathogen. In certain embodiments the pathogen is human respiratory syncytial virus (RSV). In one embodiment the present invention provides a method of generating or enhancing an immune response directed against human respiratory syncytial virus (RSV) comprising the administration of a recombinant adenovirus according to the present invention. Particularly, the method of generating or enhancing an immune response comprises the administration of an effective amount of a ChAd155-derived adenovirus comprising a transgene encoding an RSV antigen as set out in SEQ ID NO: 37, for example, in one embodiment the trangene comprises a polynucleotide of SEQ ID NO: 11. 
     In one embodiment, the present invention provides an immunogenic composition comprising a recombinant adenovirus according to the present invention, for example a ChAd155-derived adenovirus, including an expression cassette comprising an immunogenic transgene derived from a pathogen, for example human respiratory syncytial virus (RSV), and a pharmaceutically acceptable excipient. 
     Such vaccine or other immunogenic compositions may be formulated in a suitable delivery vehicle. Generally, doses for the immunogenic compositions are in the range defined below under ‘Delivery Methods and Dosage’. The levels of immunity of the selected gene can be monitored to determine the need, if any, for boosters. Following an assessment of antibody titers in the serum, optional booster immunizations may be desired. 
     In one embodiment an immunogenic composition comprising a recombinant ChAd155-derived adenoviral vector of the present invention comprising an expression cassette containing a transgene encoding an RSV F antigen and RSV M and N antigens. More specifically, the transgene encodes an RSV FΔTM antigen (fusion (F) protein deleted of the transmembrane and cytoplasmic regions), and RSV M2-1 (transcription anti-termination) and N (nucleocapsid) antigens. Particularly, the transgene encodes an RSV antigen as set out in SEQ ID NO: 37, for example, in one embodiment the trangene comprises a polynucleotide of SEQ ID NO: 11. Optionally, a vaccine or immunogenic composition of the invention may be formulated to contain other components, including, e.g., adjuvants, stabilizers, pH adjusters, preservatives and the like. Examples of suitable adjuvants are provided below under ‘Adjuvants’. Such an adjuvant can be administered with a priming DNA vaccine encoding an antigen to enhance the antigen-specific immune response compared with the immune response generated upon priming with a DNA vaccine encoding the antigen only. Alternatively, such an adjuvant can be administered with a polypeptide antigen which is administered in an administration regimen involving the ChAd155 vectors of the invention (as described below under ‘Administration Regimens’. 
     The recombinant adenoviruses are administered in an immunogenic amount, that is, an amount of recombinant adenovirus that is effective in a route of administration to transfect the desired target cells and provide sufficient levels of expression of the selected gene to induce an immune response. Where protective immunity is provided, the recombinant adenoviruses are considered to be vaccine compositions useful in preventing infection and/or recurrent disease. 
     Immunogens expressed by the inventive vectors which are useful to immunize a human or non-human animal against other pathogens include, e.g., bacteria, fungi, parasitic microorganisms or multicellular parasites which infect human and non-human vertebrates, or from a cancer cell or tumor cell. For example, immunogens may be selected from a variety of viral families. Examples of viral families against which an immune response would be desirable include respiratory viruses such as respiratory syncytial virus (RSV) and other paramyxoviruses such as human metapneumovirus, hMPV and parainfluenza viruses (PIV). 
     Infection with RSV does not confer full protective immunity. Infection in infancy is followed by symptomatic RSV re-infections which continue throughout adulthood. These re-infections generally go undiagnosed because they usually present as common acute upper respiratory tract infections. In more vulnerable persons (e.g., immunocompromised adults or elderly), re-infections can however also lead to severe disease. Both arms of the immune system (humoral and cellular immunity) are involved in protection from severe disease [American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis.  Pediatrics.  2006; 118: 1774-93. 
     Boukhvalova M S and Blanco J C. The cotton rat Sigmodon hyspidus model of respiratory syncytial virus infection.  Curr Top Microbiol Immunol.  2013; 372: 347-58. 
     Cardenas S, Auais A and Piedimonte G. Palivizumab in the prophylaxis of respiratory syncytial virus infection.  Expert Rev Anti Infect Ther.  2005; 3(5): 719-26. 
     Castilow E M and Varga S M. Overcoming T cell-mediated immunopathology to achieve safe RSV vaccination.  Future Virol.  2008; 3(5): 445-454. 
     Chin J, Magoffin R L, Shearer L A, et al., Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population.  Am J Epidemiol.  1969; 89(4): 449-63. 
     Colloca S, Barnes E, Folgori A, et al., Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species.  Sci Transl Med.  2012; 4(115): p. 115ra2. 
     Donnelly M L, Luke G, Mehrotra A, et al., Analysis of the aphthovirus 2A/2B polyprotein ‘cleavage’ mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal ‘skip’.  J Gen Virol.  2001; 82(Pt 5): 1013-25. 
     Fallaux, F J et al, (1998), Hum Gene Ther, 9:1909-1917 
     Guvenel, 2014]. 
     The humoral immune response is capable of neutralizing the virus and inhibiting viral replication, thereby playing a major role in protection against lower respiratory RSV infection and severe disease [American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis.  Pediatrics.  2006; 118: 1774-93. 
     Boukhvalova M S and Blanco J C. The cotton rat Sigmodon hyspidus model of respiratory syncytial virus infection.  Curr Top Microbiol Immunol.  2013; 372: 347-58. 
     Cardenas S, Auais A and Piedimonte G. Palivizumab in the prophylaxis of respiratory syncytial virus infection.  Expert Rev Anti Infect Ther.  2005; 3(5): 719-26. 
     Castilow E M and Varga S M. Overcoming T cell-mediated immunopathology to achieve safe RSV vaccination.  Future Virol.  2008; 3(5): 445-454. 
     Chin J, Magoffin R L, Shearer L A, et al., Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population.  Am J Epidemiol.  1969; 89(4): 449-63. 
     Colloca S, Barnes E, Folgori A, et al., Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species.  Sci Transl Med.  2012; 4(115): p. 115ra2. 
     Donnelly M L, Luke G, Mehrotra A, et al., Analysis of the aphthovirus 2A/2B polyprotein ‘cleavage’ mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal ‘skip’.  J Gen Virol.  2001; 82(Pt 5): 1013-25. 
     Fallaux, F J et al, (1998), Hum Gene Ther, 9:1909-1917 
     Guvenel A K, Chiu C and Openshaw P J. Current concepts and progress in RSV vaccine development.  Expert Rev Vaccines.  2014; 13(3): 333-44. 
     Hertz, M I, Englund J A, Snover D, et al., Respiratory syncytial virus-induced acute lung injury in adult patients with bone marrow transplants: a clinical approach and review of the literature.  Medicine  (Baltimore). 1989; 68(5): 269-81. 
     Kim H W, Canchola J G, Brandt C D et al., Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine.  Am J Epidemiol.  1969; 89(4): 422-34. 
     Magro M, Andreu D, Gómez-Puertas P, et al., Neutralization of human respiratory syncytial virus infectivity by antibodies and low-molecular-weight compounds targeted against the fusion glycoprotein.  J Virol.  2010; 84(16): 7970-82. 
     Piedra, 2003]. Passive immunization, in the form of Immunoglobulin G (IgG) RSV-neutralizing monoclonal antibodies (Synagis) given prophylactically, has been shown to prevent RSV disease to some extent in premature infants and newborns with bronchopulmonary dysplasia or underlying cardiopulmonary disease [American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis.  Pediatrics.  2006; 118: 1774-93. 
     Boukhvalova M S and Blanco J C. The cotton rat Sigmodon hyspidus model of respiratory syncytial virus infection.  Curr Top Microbiol Immunol.  2013; 372: 347-58. 
     Cardenas, 2005]. 
     T cells are also involved in the control of RSV disease. Lethal RSV infections have been described in patients with low CD8 T cells counts, as in the case of severe combined immunodeficiency, bone marrow and lung transplant recipients [Hertz, 1989]. The histopathology of fatal cases of RSV infection of newborns shows that there is a relative paucity of CD8 T cells in the lung infiltrate [Welliver, 2007]. Moreover, the presence of CD8 T cells producing Interferon-gamma (IFN-γ) has been associated with diminished Th2 responses and reduced eosinophilia in animal models of RSV [Castilow, 2008; Stevens, 2009]. 
     The recombinant vectors described herein are expected to be highly efficacious at inducing cytolytic T cells and antibodies directed to the inserted heterologous antigenic protein expressed by the vector. 
     Suitable antigens of RSV which are useful as immunogens to immunize a human or non-human animal can be selected from: the fusion protein (F), the attachment protein (G), the matrix protein (M2) and the nucleoprotein (N). The term “F protein” or “fusion protein” or “F protein polypeptide” or “fusion protein polypeptide” refers to a polypeptide or protein having all or part of an amino acid sequence of an RSV Fusion protein polypeptide. Similarly, the term “G protein” or “G protein polypeptide” refers to a polypeptide or protein having all or part of an amino acid sequence of an RSV Attachment protein polypeptide. The term “M protein” or “matrix protein” or “M protein polypeptide” refers to a polypeptide or protein having all or part of an amino acid sequence of an RSV Matrix protein and may include either or both of the M2-1 (which may be written herein as M2.1) and M2-2 gene products. Likewise, the term “N protein” or “Nucleocapsid protein” or “N protein polypeptide” refers to a polypeptide or protein having all or part of an amino acid sequence of an RSV Nucleoprotein. 
     Two groups of human RSV strains have been described, the A and B groups, based mainly on differences in the antigenicity of the G glycoprotein. Numerous strains of RSV have been isolated to date, any of which are suitable in the context of the antigens of the immunogenic combinations disclosed herein. Exemplary strains indicated by GenBank and/or EMBL Accession number can be found in US published application number 2010/0203071 (WO2008114149), which is incorporated herein by reference for the purpose of disclosing the nucleic acid and polypeptide sequences of RSV F and G proteins suitable for use in present invention. In an embodiment, the RSV F protein can be an ectodomain of an RSV F Protein (FΔTM). 
     Exemplary M and N protein nucleic acids and protein sequences can be found, e.g., in US published application number 2014/0141042 (WO2012/089833), which are incorporated herein for purpose of disclosing the nucleic acid and polypeptide sequences of RSV M and N proteins suitable for use in present invention. 
     Suitably, for use with in present invention, a transgene nucleic acid encodes an RSV F antigen and RSV M and N antigens. More specifically, the nucleic acid encodes an RSV FΔTM antigen (fusion (F) protein deleted of the transmembrane and cytoplasmic regions), and RSV M2-1 (transcription anti-termination) and N (nucleocapsid) antigens. 
     Fusion (F) Protein Deleted of the Transmembrane and Cytoplasmic Regions (F0ΔTM) 
     The RSV F protein is a major surface antigen and mediates viral fusion to target cells. The F protein is an antigen which is highly conserved among RSV subgroups and strains. The F protein is a target for neutralizing antibodies, including the prophylactic RSV-neutralizing monoclonal antibody Synagis. Deletion of the transmembrane region and cytoplasmic tail permits secretion of the FΔTM protein. Neutralizing antibodies including Synagis, that recognize this soluble form of the F protein, inhibit RSV infectivity in vitro [American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis.  Pediatrics.  2006; 118: 1774-93. 
     Boukhvalova M S and Blanco J C. The cotton rat Sigmodon hyspidus model of respiratory syncytial virus infection.  Curr Top Microbiol Immunol.  2013; 372: 347-58. 
     Cardenas S, Auais A and Piedimonte G. Palivizumab in the prophylaxis of respiratory syncytial virus infection.  Expert Rev Anti Infect Ther.  2005; 3(5): 719-26. 
     Castilow E M and Varga S M. Overcoming T cell-mediated immunopathology to achieve safe RSV vaccination.  Future Virol.  2008; 3(5): 445-454. 
     Chin J, Magoffin R L, Shearer L A, et al., Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population.  Am J Epidemiol.  1969; 89(4): 449-63. 
     Colloca S, Barnes E, Folgori A, et al., Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species.  Sci Transl Med.  2012; 4(115): p. 115ra2. 
     Donnelly M L, Luke G, Mehrotra A, et al., Analysis of the aphthovirus 2A/2B polyprotein ‘cleavage’ mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal ‘skip’.  J Gen Virol.  2001; 82(Pt 5): 1013-25. 
     Fallaux, F J et al, (1998), Hum Gene Ther, 9:1909-1917 
     Guvenel A K, Chiu C and Openshaw P J. Current concepts and progress in RSV vaccine development.  Expert Rev Vaccines.  2014; 13(3): 333-44. 
     Hertz, M I, Englund J A, Snover D, et al., Respiratory syncytial virus-induced acute lung injury in adult patients with bone marrow transplants: a clinical approach and review of the literature.  Medicine  (Baltimore). 1989; 68(5): 269-81. 
     Kim H W, Canchola J G, Brandt C D et al., Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine.  Am J Epidemiol.  1969; 89(4): 422-34. 
     Magro, 2010]. 
     Nucleocapsid (N) Protein 
     The N protein is an internal (non-exposed) antigen, highly conserved between RSV strains and known to be a source of many T cell epitopes [Townsend, 1984]. The N protein is essential for the replication and transcription of the RSV genome. The primary function of the N protein is to encapsulate the virus genome for the purposes of RNA transcription, replication and packaging and protects it from ribonucleases. 
     Transcription Anti-Termination (M2-1) Protein 
     The M2-1 protein is a transcription anti-termination factor that is important for the efficient synthesis of full-length messenger RNAs (mRNAs) as well as for the synthesis of polycistronic readthrough mRNAs, which are characteristic of non-segmented negative-strand RNA viruses. M2-1 is an internal (non-exposed) antigen, which is highly conserved between RSV strains and known to be a source of many T cell epitopes [Townsend, 1984]. 
     In one embodiment, the present invention provides a recombinant ChAd155 vector comprising a transgene encoding an RSV FΔTM antigen, and RSV M2-1 and N antigens wherein a self-cleavage site is included between the RSV FΔTM antigen and the RSV M2-1 and a flexible linker is included between the RSV M2-1 and N antigens. In one embodiment a suitable transgene nucleic acid encodes the polypeptide represented by SEQ ID NO:37 
     In one embodiment, the immunogen may be from a retrovirus, for example a lentivirus such as the Human Immunodeficiency Virus (HIV). In such an embodiment, immunogens may be derived from HIV-1 or HIV-2. 
     The HIV genome encodes a number of different proteins, each of which can be immunogenic in its entirety or as a fragment when expressed by vectors of the present invention. Envelope proteins include gp120, gp41 and Env precursor gp160, for example. Non-envelope proteins of HIV include for example internal structural proteins such as the products of the gag and pol genes and other non-structural proteins such as Rev, Nef, Vif and Tat. In an embodiment the vector of the invention encodes one or more polypeptides comprising HIV Gag. 
     The Gag gene is translated as a precursor polyprotein that is cleaved by protease to yield products that include the matrix protein (p17), the capsid (p24), the nucleocapsid (p9), p6 and two space peptides, p2 and p1, all of which are examples of fragments of Gag. 
     The Gag gene gives rise to the 55-kilodalton (kD) Gag precursor protein, also called p55, which is expressed from the unspliced viral mRNA. During translation, the N terminus of p55 is myristoylated, triggering its association with the cytoplasmic aspect of cell membranes. The membrane-associated Gag polyprotein recruits two copies of the viral genomic RNA along with other viral and cellular proteins that triggers the budding of the viral particle from the surface of an infected cell. After budding, p55 is cleaved by the virally encoded protease (a product of the pol gene) during the process of viral maturation into four smaller proteins designated MA (matrix [p17]), CA (capsid [p24]), NC (nucleocapsid [p9]), and p6, all of which are examples of fragments of Gag. In one embodiment, the vectors of the present invention comprise a Gag polypeptide of SEQ ID NO: 38. 
     Adjuvants 
     An “adjuvant” as used herein refers to a composition that enhances the immune response to an immunogen. Examples of such adjuvants include but are not limited to inorganic adjuvants (e.g. inorganic metal salts such as aluminium phosphate or aluminium hydroxide), organic adjuvants (e.g. saponins, such as QS21, or squalene), oil-based adjuvants (e.g. Freund&#39;s complete adjuvant and Freund&#39;s incomplete adjuvant), cytokines (e.g. IL-1β, IL-2, IL-7, IL-12, IL-18, GM-CFS, and INF-γ) particulate adjuvants (e.g. immuno-stimulatory complexes (ISCOMS), liposomes, or biodegradable microspheres), virosomes, bacterial adjuvants (e.g. monophosphoryl lipid A, such as 3-de-O-acylated monophosphoryl lipid A (3D-MPL), or muramyl peptides), synthetic adjuvants (e.g. non-ionic block copolymers, muramyl peptide analogues, or synthetic lipid A), synthetic polynucleotides adjuvants (e.g polyarginine or polylysine) and immunostimulatory oligonucleotides containing unmethylated CpG dinucleotides (“CpG”). 
     One suitable adjuvant is monophosphoryl lipid A (MPL), in particular 3-de-O-acylated monophosphoryl lipid A (3D-MPL). Chemically it is often supplied as a mixture of 3-de-O-acylated monophosphoryl lipid A with either 4, 5, or 6 acylated chains. It can be purified and prepared by the methods taught in GB 2122204B, which reference also discloses the preparation of diphosphoryl lipid A, and 3-O-deacylated variants thereof. Other purified and synthetic lipopolysaccharides have been described (U.S. Pat. No. 6,005,099 and EP 0 729 473 B1; Hilgers et al., 1986, Int. Arch. Allergy. Immunol., 79(4):392-6; Hilgers et al., 1987, Immunology, 60(1):141-6; and EP 0 549 074 B11). 
     Saponins are also suitable adjuvants (see Lacaille-Dubois, M and Wagner H, A review of the biological and pharmacological activities of saponins. Phytomedicine vol 2 pp 363-386 (1996)). For example, the saponin Quil A (derived from the bark of the South American tree Quillaja Saponaria Molina), and fractions thereof, are described in U.S. Pat. No. 5,057,540 and Kensil, Crit. Rev. Ther. Drug Carrier Syst., 1996, 12:1-55; and EP 0 362 279 B1. Purified fractions of Quil A are also known as immunostimulants, such as QS21 and QS17; methods of their production is disclosed in U.S. Pat. No. 5,057,540 and EP 0 362 279 B1. Also described in these references is QS7 (a non-haemolytic fraction of Quil-A). Use of QS21 is further described in Kensil et al. (1991, J. Immunology, 146: 431-437). Combinations of QS21 and polysorbate or cyclodextrin are also known (WO 99/10008). Particulate adjuvant systems comprising fractions of QuilA, such as QS21 and QS7 are described in WO 96/33739 and WO 96/11711. 
     Another adjuvant is an immunostimulatory oligonucleotide containing unmethylated CpG dinucleotides (“CpG”) (Krieg, Nature 374:546 (1995)). CpG is an abbreviation for cytosine-guanosine dinucleotide motifs present in DNA. CpG is known as an adjuvant when administered by both systemic and mucosal routes (WO 96/02555, EP 468520, Davis et al, J. Immunol, 1998, 160:870-876; McCluskie and Davis, J. Immunol., 1998, 161:4463-6). CpG, when formulated into vaccines, may be administered in free solution together with free antigen (WO 96/02555) or covalently conjugated to an antigen (WO 98/16247), or formulated with a carrier such as aluminium hydroxide (Brazolot-Millan et al., Proc. Natl. Acad. Sci., USA, 1998, 95:15553-8). 
     Adjuvants such as those described above may be formulated together with carriers, such as liposomes, oil in water emulsions, and/or metallic salts (including aluminum salts such as aluminum hydroxide). For example, 3D-MPL may be formulated with aluminum hydroxide (EP 0 689 454) or oil in water emulsions (WO 95/17210); QS21 may be formulated with cholesterol containing liposomes (WO 96/33739), oil in water emulsions (WO 95/17210) or alum (WO 98/15287); CpG may be formulated with alum (Brazolot-Millan, supra) or with other cationic carriers. 
     Combinations of adjuvants may be utilized in the present invention, in particular a combination of a monophosphoryl lipid A and a saponin derivative (see, e.g., WO 94/00153; WO 95/17210; WO 96/33739; WO 98/56414; WO 99/12565; WO 99/11241), more particularly the combination of QS21 and 3D-MPL as disclosed in WO 94/00153, or a composition where the QS21 is quenched in cholesterol-containing liposomes (DQ) as disclosed in WO 96/33739. Alternatively, a combination of CpG plus a saponin such as QS21 is an adjuvant suitable for use in the present invention. A potent adjuvant formulation involving QS21, 3D-MPL &amp; tocopherol in an oil in water emulsion is described in WO 95/17210 and is another formulation for use in the present invention. Saponin adjuvants may be formulated in a liposome and combined with an immunostimulatory oligonucleotide. Thus, suitable adjuvant systems include, for example, a combination of monophosphoryl lipid A, preferably 3D-MPL, together with an aluminium salt (e.g. as described in WO00/23105). A further exemplary adjuvant comprises comprises QS21 and/or MPL and/or CpG. QS21 may be quenched in cholesterol-containing liposomes as disclosed in WO 96/33739. 
     Other suitable adjuvants include alkyl Glucosaminide phosphates (AGPs) such as those disclosed in WO9850399 or U.S. Pat. No. 6,303,347 (processes for preparation of AGPs are also disclosed), or pharmaceutically acceptable salts of AGPs as disclosed in U.S. Pat. No. 6,764,840. Some AGPs are TLR4 agonists, and some are TLR4 antagonists. Both are thought to be useful as adjuvants. 
     It has been found (WO 2007/062656, which published as US 2011/0293704 and is incorporated by reference for the purpose of disclosing invariant chain sequences) that the fusion of the invariant chain to an antigen which is comprised by an expression system used for vaccination increases the immune response against said antigen, if it is administered with an adenovirus. Accordingly, in one embodiment of the invention, the immunogenic transgene may be co-expressed with invariant chain in a recombinant ChAd155 viral vector. 
     In another embodiment, the invention provides the use of the capsid of ChAd155 (optionally an intact or recombinant viral particle or an empty capsid is used) to induce an immunomodulatory effect response, or to enhance or adjuvant a cytotoxic T cell response to another active agent by delivering a ChAd155 capsid to a subject. The ChAd155 capsid can be delivered alone or in a combination regimen with an active agent to enhance the immune response thereto. Advantageously, the desired effect can be accomplished without infecting the host with an adenovirus. 
     Administration Regimens 
     Commonly, the ChAd155 recombinant adenoviral vectors will be utilized for delivery of therapeutic or immunogenic molecules (such as proteins). It will be readily understood for both applications, that the recombinant adenoviral vectors of the invention are particularly well suited for use in regimens involving repeat delivery of recombinant adenoviral vectors. Such regimens typically involve delivery of a series of viral vectors in which the viral capsids are alternated. The viral capsids may be changed for each subsequent administration, or after a pre-selected number of administrations of a particular serotype capsid (e.g. one, two, three, four or more). Thus, a regimen may involve delivery of a recombinant adenovirus with a first capsid, delivery with a recombinant adenovirus with a second capsid, and delivery with a recombinant adenovirus with a third capsid. A variety of other regimens which use the adenovirus capsids of the invention alone, in combination with one another, or in combination with other adenoviruses (which are preferably immunologically non-crossreactive) will be apparent to those of skill in the art. Optionally, such a regimen may involve administration of recombinant adenovirus with capsids of other non-human primate adenoviruses, human adenoviruses, or artificial sequences such as are described herein. 
     The adenoviral vectors of the invention are particularly well suited for therapeutic regimens in which multiple adenoviral-mediated deliveries of transgenes are desired, e.g., in regimens involving redelivery of the same transgene or in combination regimens involving delivery of other transgenes. Such regimens may involve administration of a ChAd155 adenoviral vector, followed by re-administration with a vector from the same serotype adenovirus. Particularly desirable regimens involve administration of a ChAd155 adenoviral vector, in which the source of the adenoviral capsid sequences of the vector delivered in the first administration differs from the source of adenoviral capsid sequences of the viral vector utilized in one or more of the subsequent administrations. For example, a therapeutic regimen involves administration of a ChAd155 vector and repeat administration with one or more adenoviral vectors of the same or different serotypes. 
     In another example, a therapeutic regimen involves administration of an adenoviral vector followed by repeat administration with a ChAd155 vector which has a capsid which differs from the source of the capsid in the first delivered adenoviral vector, and optionally further administration with another vector which is the same or, preferably, differs from the source of the adenoviral capsid of the vector in the prior administration steps. These regimens may deliver the same or different therapeutic or immunogenic molecules. These regimens are not limited to delivery of adenoviral vectors constructed using the ChAd155 sequences. Rather, these regimens can readily utilize other adenoviral sequences, including, without limitation, other adenoviral sequences including other non-human primate adenoviral sequences, or human adenoviral sequences, in combination with the ChAd155 vectors. 
     In a further example, a therapeutic regimen may involve either simultaneous (such as co-administration) or sequential (such as a prime-boost) delivery of (i) one or more ChAd155 adenoviral vectors and (ii) a further component such as non-adenoviral vectors, non-viral vectors, and/or a variety of other therapeutically useful compounds or molecules such as antigenic proteins optionally simultaneously administered with adjuvant. These regimens may deliver the same or different therapeutic or immunogenic molecules. Examples of co-administration include homo-lateral co-administration and contra-lateral co-administration (further described below under ‘Delivery Methods and Dosage’). 
     Suitable non-adenoviral vectors for use in simultaneous or particularly in sequential delivery (such as prime-boost) with one or more ChAd155 adenoviral vectors include one or more poxviral vectors. Suitably, the poxviral vector belongs to the subfamily chordopoxvirinae, more suitably to a genus in said subfamily selected from the group consisting of orthopox, parapox, yatapox, avipox (suitably canarypox (ALVAC) or fowlpox (FPV)) and molluscipox. Even more suitably, the poxviral vector belongs to the orthopox and is selected from the group consisting of vaccinia virus, NYVAC (derived from the Copenhagen strain of vaccinia), Modified Vaccinia Ankara (MVA), cowpoxvirus and monkeypox virus. Most suitably, the poxviral vector is MVA. 
     “Simultaneous” administration suitably refers to the same ongoing immune response. Preferably both components are administered at the same time (such as simultaneous administration of both DNA and protein), however, one component could be administered within a few minutes (for example, at the same medical appointment or doctor&#39;s visit), within a few hours. Such administration is also referred to as co-administration. In some embodiments, co-administration may refer to the administration of an adenoviral vector, an adjuvant and a protein component. In other embodiments, co-administration refers to the administration of an adenoviral vector and another viral vector, for example a second adenoviral vector or a poxvirus such as MVA. In other embodiments, co-administration refers to the administration of an adenoviral vector and a protein component, which is optionally adjuvanted. 
     In another embodiment, a therapeutic regimen involves the administration of an immunogenic composition to a pregnant mother and subsequent administration of a further immunogenic composition to the infant after birth, for example 1, 2, 3, 4, 5, 6, 7 or 8 months after birth. Antibodies generated as a result of the maternal immunisation can cross the placenta to provide passive immunisation of the gestational infant. In one embodiment the maternal immunisation is by administration of a recombinant protein antigen and the infant immunisation is by administration of a recombinant adenoviral vector according to the present invention. In another embodiment the maternal immunisation is by administration of a recombinant adenoviral vector according to the present invention and the infant immunisation is by administration of a recombinant protein antigen. In another embodiment both the maternal and infant immunisation is by administration of a recombinant adenoviral vector according to the present invention. 
     Thus, the present invention provides the use of a recombinant ChAd155-derived adenoviral vector according to the present invention in the generation of an immune response against RSV in an infant, particularly an infant born to a mother immunised against RSV during pregnancy. Accordingly, the present invention provides the use of a recombinant ChAd155-derived adenoviral vector comprising an immunogenic transgene derived from human respiratory syncytial virus (RSV) in the manufacture of a medicament for the generation of an immune response in an infant. Desirably, particularly the infant born to a mother immunised against RSV during her pregnancy. More specifically, the transgene encodes an RSV FΔTM antigen (fusion (F) protein deleted of the transmembrane and cytoplasmic regions), and RSV M2-1 (transcription anti-termination) and N (nucleocapsid) antigens. Particularly, the transgene encodes an RSV antigen as set out in SEQ ID NO: 37, for example, in one embodiment the trangene comprises a polynucleotide of SEQ ID NO: 11. 
     A prime-boost regimen may be used. Prime-boost refers to two separate immune responses in the same individual: (i) an initial priming of the immune system followed by (ii) a secondary or boosting of the immune system many weeks or months after the primary immune response has been established. 
     Such a regimen may involve the administration of a recombinant ChAd155 vector to prime the immune system to second, booster, administration with a traditional antigen, such as a protein (optionally co-administered with adjuvant), or a recombinant virus carrying the sequences encoding such an antigen (e.g., WO 00/11140). Alternatively, an immunization regimen may involve the administration of a recombinant ChAd155 vector to boost the immune response to a vector (either viral or DNA-based) encoding an antigen. In another alternative, an immunization regimen involves administration of a protein followed by booster with a recombinant ChAd155 vector encoding the antigen. In one example, the prime-boost regimen can provide a protective immune response to the virus, bacteria or other organism from which the antigen is derived. In another embodiment, the prime-boost regimen provides a therapeutic effect that can be measured using conventional assays for detection of the presence of the condition for which therapy is being administered. 
     Preferably, a boosting composition is administered about 2 to about 27 weeks after administering the priming composition to the subject. The administration of the boosting composition is accomplished using an effective amount of a boosting composition containing or capable of delivering the same antigen or a different antigen as administered by the priming vaccine. The boosting composition may be composed of a recombinant viral vector derived from the same viral source or from another source. Alternatively, the boosting composition can be a composition containing the same antigen as encoded in the priming vaccine, but in the form of a protein, which composition induces an immune response in the host. The primary requirements of the boosting composition are that the antigen of the composition is the same antigen, or a cross-reactive antigen, as that encoded by the priming composition. 
     Delivery Methods and Dosage 
     The vector may be prepared for administration by being suspended or dissolved in a pharmaceutically or physiologically acceptable carrier such as isotonic saline; isotonic salts solution or other formulations that will be apparent to those skilled in the art. The appropriate carrier will be evident to those skilled in the art and will depend in large part upon the route of administration. The compositions described herein may be administered to a mammal in a sustained release formulation using a biodegradable biocompatible polymer, or by on-site delivery using micelles, gels and liposomes. 
     In some embodiments, the recombinant adenovirus of the invention is administered to a subject by intramuscular injection, intravaginal injection, intravenous injection, intraperitoneal injection, subcutaneous injection, epicutaneous administration, intradermal administration, nasal administration or oral administration. 
     If the therapeutic regimen involves co-administration of one or more ChAd155 adenoviral vectors and a further component, each formulated in different compositions, they are favourably administered co-locationally at or near the same site. For example, the components can be administered (e.g. via an administration route selected from intramuscular, transdermal, intradermal, sub-cutaneous) to the same side or extremity (“co-lateral” administration) or to opposite sides or extremities (“contra-lateral” administration). 
     Dosages of the viral vector will depend primarily on factors such as the condition being treated, the age, weight and health of the patient, and may thus vary among patients. For example, a therapeutically effective adult human or veterinary dosage of the viral vector generally contains 1×10 5  to 1×10 15  viral particles, such as from 1×10 8  to 1×10 12  (e.g., 1×10 8 , 2.5×10 8 , 5×10 8 , 1×10 9 , 1.5×10 9 , 2.5×10 9 , 5×10 9 , 1×10 10 , 1.5×10 10 , 2.5×10 10 , 5×10 10 , 1×10 11  1.5×10 11 , 2.5×10 11 , 5×10 11 , 1×10 12  particles). Alternatively, a viral vector can be administered at a dose that is typically from 1×10 5  to 1×10 10  plaque forming units (PFU), such as 1×10 5  PFU, 2.5×10 5  PFU, 5×10 5  PFU, 1×10 6  PFU, 2.5×10 6  PFU, 5×10 6  PFU, 1×10 7  PFU, 2.5×10 7  PFU, 5×10 7  PFU, 1×10 8  PFU, 2.5×10 8  PFU, 5×10 8  PFU, 1×10 9  PFU, 2.5×10 9  PFU, 5×10 9  PFU, or 1×10 10  PFU. Dosages will vary depending upon the size of the animal and the route of administration. For example, a suitable human or veterinary dosage (for about an 80 kg animal) for intramuscular injection is in the range of about 1×10 9  to about 5×10 12  particles per mL, for a single site. Optionally, multiple sites of administration may be used. In another example, a suitable human or veterinary dosage may be in the range of about 1×10 11  to about 1×10 15  particles for an oral formulation. 
     The viral vector can be quantified by Quantitative PCR Analysis (Q-PCR), for example with primers and probe designed on CMV promoter region using as standard curve serial dilution of plasmid DNA containing the vector genome with expression cassette including HCMV promoter. The copy number in the test sample is determined by the parallel line analysis method. Alternative methods for vector particle quantification can be analytical HPLC or spectrophotometric method based on A 260  nm. 
     An immunologically effective amount of a nucleic acid may suitably be between 1 ng and 100 mg. For example, a suitable amount can be from 1 μg to 100 mg. An appropriate amount of the particular nucleic acid (e.g., vector) can readily be determined by those of skill in the art. Exemplary effective amounts of a nucleic acid component can be between 1 ng and 100 μg, such as between 1 ng and 1 μg (e.g., 100 ng-1 μg), or between1 μg and 100 μg, such as 10 ng, 50 ng, 100 ng, 150 ng, 200 ng, 250 ng, 500 ng, 750 ng, or 1 μg. Effective amounts of a nucleic acid can also include from 1 μg to 500 μg, such as between 1 μg and 200 μg, such as between 10 and 100 μg, for example 1 μg, 2 μg, 5 μg, 10 μg, 20 μg, 50 μg, 75 μg, 100 μg, 150 μg, or 200 μg. Alternatively, an exemplary effective amount of a nucleic acid can be between 100 μg and 1 mg, such as from 100 μg to 500 μg, for example, 100 μg, 150 μg, 200 μg, 250 μg, 300 μg, 400 μg, 500 μg, 600 μg, 700 μg, 800 μg, 900 μg or 1 mg. 
     Generally a human dose will be in a volume of between 0.1 ml and 2 ml. Thus the composition described herein can be formulated in a volume of, for example 0.1, 0.15, 0.2, 0.5, 1.0, 1.5 or 2.0 ml human dose per individual or combined immunogenic components. 
     One of skill in the art may adjust these doses, depending on the route of administration and the therapeutic or vaccine application for which the recombinant vector is employed. The levels of expression of the transgene, or for an adjuvant, the level of circulating antibody, can be monitored to determine the frequency of dosage administration. 
     If one or more priming and/or boosting steps are used, this step may include a single dose that is administered hourly, daily, weekly or monthly, or yearly. As an example, mammals may receive one or two doses containing between about 10 μg to about 50 μg of plasmid in carrier. 
     The amount or site of delivery is desirably selected based upon the identity and condition of the mammal. 
     The therapeutic levels of, or level of immune response against, the protein encoded by the selected transgene can be monitored to determine the need, if any, for boosters. Following an assessment of CD8+ T cell response, or optionally, antibody titers, in the serum, optional booster immunizations may be desired. Optionally, the recombinant ChAd155 vectors may be delivered in a single administration or in various combination regimens, e.g., in combination with a regimen or course of treatment involving other active ingredients or in a prime-boost regimen. 
     The present invention will now be further described by means of the following non-limiting examples. 
     EXAMPLES 
     Example 1: Isolation of ChAd155 
     Wild type chimpanzee adenovirus type 155 (ChAd155) was isolated from a healthy young chimpanzee housed at the New Iberia Research Center facility (New Iberia Research Center; The University of Louisiana at Lafayette) using standard procedures as described in Colloca et al. (2012) and WO 2010086189, which is hereby incorporated by reference for the purpose of describing adenoviral isolation and characterization techniques 
     Example 2: ChAd155 Vector Construction 
     The ChAd155 viral genome was then cloned in a plasmid or in a BAC vector and subsequently modified ( FIG. 2 ) to carry the following modifications in different regions of the ChAd155 viral genome: 
     a) deletion of the E1 region (from bp 449 to bp 3529) of the viral genome; 
     b) deletion of the E4 region (from bp 34731 to bp 37449) of the viral genome; 
     c) insertion of the E4orf6 derived from human AdS. 
     2.1: Deletion of E1 Region: Construction of BAC/ChAd155 ΔE1 TetO hCMV RpsL-Kana #1375 
     The ChAd155 viral genome was cloned into a BAC vector by homologous recombination in  E. coli  strain BJ5183 electroporation competent cells (Stratagene catalog no. 2000154) co-transformed with ChAd155 viral DNA and Subgroup C BAC Shuttle (#1365). As shown in the schematic of  FIG. 3 , the Subgroup C Shuttle is a BAC vector derived from pBeloBAC11 (GenBank U51113, NEB) and which is dedicated to the cloning of ChAd belonging to species C and therefore contains the pIX gene and DNA fragments derived from right and left ends (including right and left ITRs) of species C ChAd viruses. 
     The Species C BAC Shuttle also contains a RpsL-Kana cassette inserted between left end and the pIX gene. In addition, an Amp-LacZ-SacB selection cassette, flanked by ISceI restriction sites, is present between the pIX gene and right end of the viral genome. In particular, the BAC Shuttle comprised the following features: Left ITR: bp 27 to 139, hCMV(tetO) RpsL-Kana cassette: bp 493 to 3396, pIX gene: bp 3508 to 3972, ISceI restriction sites: bp 3990 and 7481, Amp-LacZ-SacB selection cassette: bp 4000 to 7471, Right ITR: bp 7805 to 7917. 
     BJ5183 cells were co-transformed by electroporation with ChAd155 purified viral DNA and Subgroup C BAC Shuttle vector digested with ISceI restriction enzyme and then purified from gel. Homologous recombination occurring between pIX gene and right ITR sequences (present at the ends of Species C BAC Shuttle linearized DNA) and homologous sequences present in ChAd155 viral DNA lead to the insertion of ChAd155 viral genomic DNA in the BAC shuttle vector. At the same time, the viral E1 region was deleted and substituted by the RpsL-Kana cassette, generating BAC/ChAd155 ΔE1/TetO hCMV RpsL-Kana #1375. 
     2.2: Plasmid Construction by Homologous Recombination in  E. coli  BJ5183 
     2.2.1: Deletion of E4 Region—Construction of pChAd155 ΔE1, E4_Ad5E4orf6/TetO hCMV RpsL-Kana (#1434) 
     To improve propagation of the vector, a deletion of the E4 region spanning from nucleotide 34731-37449 (ChAd155 wild type sequence) was introduced in the vector backbone by replacing the native E4 region with Ad5 E4orf6 coding sequence using a strategy involving several steps of cloning and homologous recombination in  E. coli.  The E4 coding region was completely deleted while the E4 native promoter and polyadenylation signal were conserved. To this end, a shuttle vector was constructed to allow the insertion of Ad5orf6 by replacing the ChAd155 native E4 region by homologous recombination in  E. coli  BJ5183 as detailed below. 
     Construction of pARS SpeciesC Ad5E4orf6-1 
     A DNA fragment containing Ad5orf6 was obtained by PCR using Ad5 DNA as template, with the oligonucleotides 5′-ATACGGACTAGTGGAGAAGTACTCGCCTACATG-3′ (SEQ ID NO: 13) and 5′-ATACGGAAGATCTAAGACTTCAGGAAATATGACTAC-3′ (SEQ ID NO: 14). The PCR fragment was digested with BgIII and SpeI and cloned into Species C RLD-EGFP shuttle digested with BgIII and SpeI, generating the plasmid pARS Species C Ad5orf6-1. Details regarding the shuttle can be found in Colloca et al, Sci. Transl. Med. (2012) 4:115ra. 
     Construction of pARS SpeciesC Ad5E4orf6-2 
     To delete the E4 region, a 177 bp DNA fragment spanning bp 34586 to bp 34730 of the ChAd155 wt sequence (SEQ ID NO: 10) was amplified by PCR using the plasmid BAC/ChAd155 ΔE1_TetO hCMV RpsL-Kana (#1375) as a template with the following oligonucleotides: 5′-ATTCAGTGTACAGGCGCGCCAAAGCATGACGCTGTTGATTTGATTC-3′ (SEQ ID NO: 15) and 5′-ACTAGGACTAGTTATAAGCTAGAATGGGGCTTTGC-3′ (SEQ ID NO: 16). The PCR fragment was digested with BsrGI and SpeI and cloned into pARS SubGroupC Ad5orf6-1 digested with BsrGI and SpeI, generating the plasmid pARS SpeciesC Ad5orf6-2 (#1490). A schematic diagram of this shuttle plasmid is provided in  FIG. 4 . In particular, the shuttle plasmid comprised the following features: Left ITR: bp 1 to 113, Species C first 460bp: bp 1 to 460, ChAd155 wt (bp 34587 to bp 34724 of SEQ ID NO:10): bp 516 to 650, Ad5 orf6: bp 680 and 1561, Species C last 393 bp: bp 1567 to 1969, Right ITR: bp 1857 to 1969. 
     Construction of pChAd155 ΔE1, E4_Ad5E4orf6/TetO hCMV RpsL-Kana (#1434) 
     The resulting plasmid pARS SubGroupC Ad5orf6-2 was then used to replace the E4 region within the ChAd155 backbone with Ad5orf6. To this end the plasmid BAC/ChAd155 ΔE1_TetO hCMV RpsL-Kana (#1375) was digested with PacI/PmeI and co-transformed into BJ5183 cells with the digested plasmid pARS SubGroupC Ad5orf6-2 BsrGI/AscI, to obtain the pChAd155 ΔE1, E4_Ad5E4orf6/TetO hCMV RpsL-Kana (#1434) pre-adeno plasmid. 
     2.2.2: Insertion of RSV Expression Cassette—Construction of pChAd155 ΔE1, E4_Ad5E4orf6/TetO hCMV RSV 
     The vaccine antigens are computational consensus sequences derived from the alignment of many different subgroup A RSV isolates retrieved from the National Centre for Biotechnology Information (NCBI) database. For each antigen the protein consensus sequence was derived using Multiple Sequence Comparison by Log-Expectation (MUSCLE) version 3.6 by alignment of all non-identical sequences and applying the majority rule. When blasted, the derived consensus sequence of the F protein was found to differ by only one amino acid from a natural annotated variant: embCAA26143.1. The consensus N protein also had only one amino acid different from the annotated variant ID:1494470, while the M2-1 protein was identical to the variant P04545. Finally, each antigenic sequence was codon-optimized for expression in eukaryotic cells, chemically synthesized and assembled. The construct, shown in  FIG. 14  and SEQ ID NO: 37 contains the aphtovirus Foot and Mouth Disease Virus 2A region (18 amino acids) between the soluble F protein FΔTM and the other two RSV antigens, which mediates polyprotein processing by a translational effect known as ribosomal skip [American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis.  Pediatrics.  2006; 118: 1774-93. 
     Boukhvalova M S and Blanco J C. The cotton rat Sigmodon hyspidus model of respiratory syncytial virus infection.  Curr Top Microbiol Immunol.  2013; 372: 347-58. 
     Cardenas S, Auais A and Piedimonte G. Palivizumab in the prophylaxis of respiratory syncytial virus infection.  Expert Rev Anti Infect Ther.  2005; 3(5): 719-26. 
     Castilow E M and Varga S M. Overcoming T cell-mediated immunopathology to achieve safe RSV vaccination.  Future Virol.  2008; 3(5): 445-454. 
     Chin J, Magoffin R L, Shearer L A, et al., Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population.  Am J Epidemiol.  1969; 89(4): 449-63. 
     Colloca S, Barnes E, Folgori A, et al., Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species.  Sci Transl Med.  2012; 4(115): p. 115ra2. 
     Donnelly, 2001]. After transfection into mammalian cells, cleavage occurs and the soluble F protein is detected in the cell culture supernatant. The fusion protein N-M2-1 is instead expressed and detected in the intracellular fraction. 
     An RSV cassette was cloned into a linearised pre-adeno acceptor vector via homologous recombination in  E. coli  by exploiting the homology existing between HCMV promoter and BGH polyA sequences. The plasmid pvjTetOhCMV-bghpolyA_RSV was cleaved with SfiI and SpeI to excise the 4.65 Kb fragment containing the HCMV promoter with tetO, RSV and BGHpolyA sequence. The resulting RSV 4.65 Kb fragment was cloned by homologous recombination into the pChAd155 ΔE1, E4_Ad5E4orf6/TetO hCMV RpsL-Kana (#1434) acceptor vector carrying the RpsL-Kana selection cassette under control of HCMV and BGHpA. The acceptor pre-adeno plasmid was linearized with the restriction endonuclease SnaBI. The resulting construct was the pChAd155 ΔE1, E4_Ad5E4orf6/TetO hCMV RSV vector ( FIG. 5 ). 
     2.3: BAC Vector Construction by Recombineering 
     2.3.1: Deletion of E4 Region—Construction of BAC/ChAd155 ΔE1, E4_Ad5E4orf6/TetO hCMV RpsL-Kana #1390 
     A deletion of the E4 region spanning from nucleotide 34731-37449 of the ChAd155 wt sequence was introduced in the vector backbone by replacing this native E4 region with the Ad5 E4orf6 coding sequence using a strategy involving two different steps of recombineering in  E. coli  SW102 competent cells. 
     The first step resulted in insertion of a selection cassette including the suicide gene SacB, ampicillin-R gene and lacZ (Amp-LacZ-SacB selection cassette) in the E4 region of ChAd155, for the purpose of positive/negative selection of recombinants. 
     First Step—Substitution of ChAd155 Native E4 Region with Amp-LacZ-SacB Selection Cassette 
     The Amp-LacZ-SacB selection cassette was amplified by PCR using the oligonucleotides provided below containing E4 flanking sequences to allow homologous recombination: 
     
       
         
           
               
            
               
                 1021-FW E4 Del Stepl 
               
               
                 (SEQ ID NO: 17) 
               
               
                 (5′- 
               
               
                   
               
               
                 TTAATAGACACAGTAGCTTAATAGACCCAGTAGTGCAAAGCCCCATTCTA 
               
               
                   
               
               
                 GCTTATAACCCCTATTTGTTTATTTTTCT-3′) 
               
               
                 and 
               
               
                   
               
               
                 1022-RW E4 Del Step1 
               
               
                 (SEQ ID NO: 18) 
               
               
                 (5′- 
               
               
                   
               
               
                 ATATATACTCTCTCGGCACTTGGCCTTTTACACTGCGAAGTGTTGGTGCT 
               
               
                   
               
               
                 GGTGCTGCGTTGAGAGATCTTTATTTGTTAACTGTTAATTGTC-3′). 
               
            
           
         
       
     
     The PCR product was used to transform  E. coli  SW102 competent cells containing the pAdeno plasmid BAC/ChAd155 (DE1) tetO hCMV—RpsLKana #1375. The transformation of SW102 cells allowed the insertion of the selection cassette in the E4 region of ChAd155 via lambda (λ) Red-mediated homologous recombination, thus obtaining BAC/ChAd155 (DE1) TetOhCMV—RpsL Kana #1379 (including Amp-LacZ-SacB cassette by substituting ChAd155 native E4 region). 
     Second Step—Substitution of Amp-IacZ-SacB Selection Cassette with Ad5E4orf6 Region 
     The resulting plasmid BAC/ChAd155 (DE1) TetOhCMV—RpsL Kana #1379 (with Amp-LacZ-SacB cassette in place of ChAd155 E4 region) was then manipulated to replace the Amp-lacZ-SacB selection cassette with Ad5orf6 within the ChAd155 backbone. To this end, a DNA fragment containing the Ad5orf6 region was obtained by PCR, using the oligonucleotides 1025-FW E4 Del Step2 (5′-TTAATAGACACAGTAGCTTAATA-3′) (SEQ ID NO: 19) and 1026-RW E4 Del Step2 (5′-GGAAGGGAGTGTCTAGTGTT-3′) (SEQ ID NO: 20). The resulting DNA fragment was introduced into  E. coli  SW102 competent cells containing the pAdeno plasmid BAC/ChAd155 (DE1) TetOhCMV—RpsL Kana) #1379, resulting in a final plasmid BAC/ChAd155 (DE1, E4 Ad5E4orf6) TetOhCMV—RpsL Kana #1390 containing Ad5orf6 substituting the native ChAd155 E4 region. 
     2.3.2: Insertion of RSV Expression Cassette: Construction of BAC/ChAd155 ΔE1, E4_Ad5E4orf6/TetOhCMV RSV #1393 
     An RSV transgene was cloned into the BAC/ChAd155 ΔE1, E4_Ad5E4orf6/TetOhCMV RpsL Kana #1390 vector by substituting the RpsL-Kana selection cassette. The construction strategy was based on two different steps of recombineering in  E. coli  SW102 competent cells. 
     First Step—Substitution of RpsL-Kana Cassette with Amp-LacZ-SacB Selection Cassette 
     The Amp-LacZ-SacB selection cassette was obtained from plasmid BAC/ChAd155 (DE1) TetO hCMV Amp-LacZ-SacB #1342 by PCR using the oligonucleotides 91-SubMonte FW (5′-CAATGGGCGTGGATAGCGGTTTGAC-3′) (SEQ ID NO: 21) and 890-BghPolyA RW (5′-CAGCATGCCTGCTATTGTC-3′) (SEQ ID NO: 22). The product was transformed into  E. coli  SW102 competent cells containing the pAdeno plasmid BAC/ChAd155 (DE1, E4 Ad5E4orf6) TetOhCMV—RpsL Kana #1390, resulting in BAC/ChAd155 (DE1, E4 Ad5E4orf6) TetOhCMV—Amp-LacZ-SacB #1386. 
     Second Step—Substitution of Amp-lacZ-SacB Selection Cassette with RSV Transgene 
     The RSV transgene was inserted in plasmid BAC/ChAd155 (DE1, E4 Ad5E4orf6) TetOhCMV—Amp-LacZ-SacB #1386 by replacing the Amp-lacZ-SacB selection cassette by homologous recombination. To this end, the plasmid pvjTetOhCMV-bghpolyA_RSV #1080 (containing an RSV expression cassette) was cleaved with SpeI and SfiI to excise the 4.4 Kb fragment including the HCMV promoter, RSV and BGHpolyA. The resulting RSV 4.4 Kb fragment was transformed into  E. coli  SW102 competent cells containing the pAdeno plasmid BAC/ChAd155 (DE1, E4 Adr5E4orf6) TetOhCMV—Amp-LacZ-SacB #1386, resulting in the final plasmid BAC/ChAd155 ΔE1, E4_Ad5E4orf6/TetO hCMV RSV #1393. The structure of the BAC carrying ChAd155/RSV (SEQ ID NO: 11) is illustrated in  FIG. 6 . In particular, ChAd155/RSV comprised the following features: Species C Left ITR: bp 1 to 113, hCMV(tetO) bp 467 to 1311, RSV gene: bp 1348 to 4785, bghpolyA: by 4815 to 5032, Ad5E4orf6: bp 36270 to 37151, Species C Right ITR: bp 37447 to 37559. 
     Example 3: Vector Production 
     The productivity of ChAd155 was evaluated in comparison to ChAd3 and PanAd3 in the Procell 92 cell line. 
     3.1: Production of Vectors comprising an HIV Gag Transgene 
     Vectors expressing the HIV Gag protein were prepared as described above (ChAd155/GAG) or previously (ChAd3/GAG Colloca et al, Sci. Transl. Med. (2012) 4:115ra). ChAd3/GAG and ChAd155/GAG were rescued and amplified in Procell 92 until passages 3 (P3); P3 lysates were used to infect 2 T75 flasks of Procell 92 cultivated in monolayer with each vector. A multiplicity of infection (MOI) of 100 vp/cell was used for both infection experiments. The infected cells were harvested when full CPE was evident (72 hours post-infection) and pooled; the viruses were released from the infected cells by 3 cycles of freeze/thaw (−70°/37° C.) then the lysate was clarified by centrifugation. The clarified lysates were quantified by Quantitative PCR Analysis with primers and probe complementary to the CMV promoter region. The oligonucleotide sequences are the following: CMVfor 5′-CATCTACGTATTAGTCATCGCTATTACCA-3′ (SEQ ID NO: 23), CMVrev 5′-GACTTGGAAATCCCCGTGAGT-3′ (SEQ ID NO: 24), CMVFAM-TAMRA probe 5′-ACATCAATGGGCGTGGATAGCGGTT-3′ (SEQ ID NO: 25) (QPCRs were run on ABI Prism 7900 Sequence detector—Applied Biosystem). The resulting volumetric titers (vp/ml) measured on clarified lysates and the specific productivity expressed in virus particles per cell (vp/cell) are provided in Table 1 below and illustrated in  FIG. 7 . 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Vector productivity from P3 lysates. 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                   
                 Total vp 
                   
               
               
                   
                 Vector 
                 vp/ml 
                 (20 ml conc.) 
                 vp/cell 
               
               
                   
                   
               
               
                   
                 ChAd3/GAG 
                 9.82E+09 
                 1.96E+11 
                 6.61E+03 
               
               
                   
                 ChAd155/GAG 
                 1.11E+10 
                 2.22E+11 
                 7.46E+03 
               
               
                   
                   
               
            
           
         
       
     
     To confirm the higher productivity of the ChAd155 vector expressing HIV Gag transgene, a second experiment was performed by using purified viruses as inoculum. To this end, Procell 92 cells were seeded in a T25 Flask and infected with ChAd3/GAG and ChAd155/GAG when the confluence of the cells was about 80%, using a MOI=100 vp/cell of infection. The infected cells were harvested when full CPE was evident; the viruses were released from the infected cells by freeze/thaw and clarified by centrifugation. The clarified lysates were quantified by Quantitative PCR Analysis by using following primers and probe: CMVfor 5′-CATCTACGTATTAGTCATCGCTATTACCA-3′ (SEQ ID NO: 23), CMV rev GACTTGGAAATCCCCGTGAGT (SEQ ID NO: 24), CMV FAM-TAMRA probe 5′-ACATCAATGGGCGTGGATAGCGGTT-3′ (SEQ ID NO: 25) complementary to the CMV promoter region (samples were analysed on an ABI Prism 7900 Sequence detector—Applied Biosystems). The resulting volumetric titers (vp/ml) measured on clarified lysates and the specific productivity expressed in virus particles per cell (vp/cell) are provided in Table 2 below and illustrated in  FIG. 8 . 
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Vector productivity from purified viruses. 
               
            
           
           
               
               
               
               
            
               
                   
                   
                 Total vp/T25 flask 
                   
               
               
                 Vector 
                 vp/ml 
                 (5 ml of lysate) 
                 vp/cell 
               
               
                   
               
               
                 ChAd3/GAG 
                 1.00E+10 
                 5.00E+10 
                 1.67E+04 
               
               
                 ChAd155/GAG 
                 1.21E+10 
                 6.05E+10 
                 2.02E+04 
               
               
                   
               
            
           
         
       
     
     3.2: Production of Vectors comprising an RSV Transgene 
     A different set of experiments were performed to evaluate the productivity of RSV vaccine vectors in Procell 92.S cultivated in suspension. The experiment compared PanAd3/RSV (described in WO2012/089833) and Chad155/RSV in parallel by infecting Procell 92.S at a cell density of 5×10 5  cells/ml. The infected cells were harvested 3 days post infection; the virus was released from the infected cells by 3 cycles of freeze/thaw and the lysate was clarified by centrifugation. The clarified lysates were then quantified by Quantitative PCR Analysis as reported above. The volumetric productivity and the cell specific productivity are provided in Table 3 below and illustrated in  FIG. 9 . 
     
       
         
           
               
               
               
               
               
             
               
                   
                 TABLE 3 
               
               
                   
                   
               
               
                   
                   
                 Volumetric 
                   
                 Cell specific 
               
               
                   
                   
                 productivity 
                   
                 productivity 
               
               
                   
                 Virus 
                 (Vp/ml) 
                 Total vp 
                 (vp/cell) 
               
               
                   
                   
               
             
            
               
                   
                 PanAd3/RSV 
                 5.82E+09 
                 2.91E+11 
                 1.16E+4  
               
               
                   
                 ChAd155/RSV 
                 3.16E+10 
                 1.58E+12 
                 6.31E+04 
               
               
                   
                   
               
            
           
         
       
     
     Example 4: Transgene Expression Levels 
     4.1: Expression Level of HIV Gag Transgene 
     Expression levels were compared in parallel experiments by infecting HeLa cells with ChAd3 and ChAd155 vectors comprising an HIV Gag transgene. HeLa cells were seeded in 24 well plates and infected in duplicate with ChAd3/GAG and ChAd155/GAG purified viruses using a MOI=250 vp/cell. The supernatants of HeLa infected cells were harvested 48 hours post-infection, and the production of secreted HIV GAG protein was quantified by using a commercial ELISA Kit (HIV-1 p24 ELISA Kit, PerkinElmer Life Science). The quantification was performed according to the manufacturer&#39;s instruction by using an HIV-1 p24 antigen standard curve. The results, expressed in pg/ml of GAG protein, are illustrated in  FIG. 10 . 
     4.1: Expression Level of RSV F Transgene 
     Expression levels were compared in parallel experiments by infecting HeLa cells with the above-described PanAd3 and ChAd155 vectors comprising an RSV F transgene. To this end, HeLa cells were seeded in 6 well plates and infected in duplicate with PanAd3/RSV and ChAd155/RSV purified viruses using a MOI=500 vp/cell. The supernatants were harvested 48 hours post-infection, and the production of secreted RSV F protein was quantified by ELISA. Five different dilutions of the supernatants were transferred to microplate wells which are coated with a commercial mouse anti-RSV F monoclonal antibody. The captured antigen was revealed using a secondary anti-RSV F rabbit antiserum followed by Biotin-conjugated anti-rabbit IgG, then by adding Streptavidin-AP conjugate (BD Pharmingen cat. 554065). The quantification was performed by using an RSV F protein (Sino Biological cat. 11049-V08B) standard curve. The results obtained, expressed as ug/ml of RSV F protein, are provided in Table 4 below. 
     
       
         
           
               
               
               
             
               
                   
                 TABLE 4 
               
               
                   
                   
               
               
                   
                 Sample 
                 μg/ml RSV F protein 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 ChAd155/RSV 
                 5.9 
               
               
                   
                 PanAd3/RSV 
                 4 
               
               
                   
                   
               
            
           
         
       
     
     A western blot analysis was also performed to confirm the higher level of transgene expression provided by the ChAd155 RSV vector relative to the PanAd3 RSV vector. HeLa cells plated in 6 well plates were infected with PanAd3/RSV and ChAd155/RSV purified viruses using MOI=250 and 500 vp/cell. The supernatants of HeLa infected cells were harvested and the production of secreted RSV F protein were analysed by non-reducing SDS gel followed by Western Blot analysis. Equivalent quantities of supernatants were loaded on non-reducing SDS gel; after electrophoresis separation, the proteins were transferred to a nitrocellulose membrane to be probed with an anti-RSV F mouse monoclonal antibody (clone RSV-F-3 catalog no: ABIN308230 available at antibodies-online.com (last accessed 13 Apr. 2015). After the incubation with primary antibody, the membrane was washed and then incubated with anti-mouse HRP conjugate secondary antibody. Finally the assay was developed by electrochemiluminescence using standard techniques (ECL detection reagents Pierce catalog no W3252282). The Western Blot results are shown in  FIG. 11 . A band of about 170 kD indicated by the arrow was revealed by monoclonal antibody mAb 13 raised against the F protein, which corresponds to the expected weight of trimeric F protein. It can be seen that the ChAd155 RSV vector produced a darker band at both MOI=250 and 500 vp/cell. 
     Example 5: Evaluation of Immunological Potency by Mouse Immunization Experiments 
     5.1: Immunogenicity of Vectors comprising the HIV Gag Transgene 
     The immunogenicity of the ChAd155/GAG vector was evaluated in parallel with the ChAd3/GAG vector in BALB/c mice (5 per group). The experiment was performed by injecting 10 6  viral particles intramuscularly. T-cell response was measured 3 weeks after the immunization by ex vivo IFN-gamma enzyme-linked immunospot (ELISpot) using a GAG CD8+ T cell epitope mapped in BALB/c mice. The results are shown in  FIG. 12 , expressed as IFN-gamma Spot Forming Cells (SFC) per million of splenocytes. Each dot represents the response in a single mouse, and the line corresponds to the mean for each dose group. Injected dose in number of virus particles and frequency of positive mice to the CD8 immunodominant peptide are shown on the x axis. 
     5.2 Immunogenicity of Vectors comprising the RSV Transgene 
     Preclinical studies to evaluate the immunogenicity of the vaccine candidate ChAd155-RSV were performed in inbred BALB/c mice (5.2.1). The vaccine efficacy was also evaluated in cotton rats after intranasal (IN) challenge with RSV through measurement of viral load in lower (lung) or upper (nasal tissue) respiratory tract (5.2.2). Finally, the vaccine was tested in young seronegative calves, which is a model that mimics natural RSV infection (5.2.3). 
     5.2.1—Inbred Mice 
     ChAd155-RSV was tested in the BALB/c mouse strain to evaluate its immunological potency. Dose escalation in inbred mice is the standard assay that has enabled the ranking of chimpanzee adenoviral vectors immunological potency in mice with results that have been confirmed consistently across species (non-human primates and humans) [Colloca, 2012]. 
     The immunological potency of the PanAd3/RSV and ChAd155/RSV vectors was evaluated in BALB/c mice. Both vectors were injected intramuscularly at doses of 3×10 6 , 10 7 , and 10 8  vp. Three weeks after vaccination the splenocytes of immunized mice were isolated and analyzed by IFN-gamma-ELISpot using as antigens immunodominant peptide F and M epitopes mapped in BALB/c mice. The levels of immune-responses were reduced in line with decreasing dosage (as expected) but immune responses were clearly higher in the groups of mice immunized with ChAd155/RSV vector compared to the equivalent groups of mice immunized with PanAd3/RSV vaccine ( FIG. 13 ). In  FIG. 13 , symbols show individual mouse data, expressed as IFN-gamma Spot Forming Cells (SFC)/million splenocytes, calculated as the sum of responses to the three immunodominant epitopes (F 51-66  F 85-93  and M2-1 282-290 ) and corrected for background. Horizontal lines represent the mean number of IFN-gamma SFC/million splenocytes for each dose group. A T cell dose response was observed in ChAd155-RSV immunized mice with all mice responding even at the low 3×10 6  vp dosage. PanAd3-RSV induced comparable responses at the highest dosage, while ChAd155-RSV induced higher responses at the two lower dosages ( FIG. 13 ). 
     In a second study, a group of BALB/c mice received ChAd155-RSV and another group received PanAd3-RSV, IM at a single dose of 5×10 8  vp. The mice (n=5/group) were subsequently bled every two weeks starting from Week 4 post-vaccination up to Week 10, to monitor induction and maintenance of anti F antibodies. Pooled sera from immunized mice were tested in Enzyme-Linked Immunosorbent Assay (ELISA) on coated RSV-F protein.  FIG. 15  shows RSV F Immunoglobulin G (IgG) titers, measured by ELISA in pooled sera from immunized mice at different time points from vaccination. Pooled sera serial dilutions were plated in RSV-F protein coated ELISA wells, and the binding of specific IgG revealed using a goat anti-mouse IgG conjugated to Alkaline Phosphatase (AP) and p-Nitrophenyl Phosphate (pNPP) substrate. The reaction was allowed to proceed over time and read at 405 nanometres (nm) during fixed time points. Data are expressed as endpoint titers calculated as the dilution of serum giving an optical density (OD) 405  reading greater than three Standard Deviations (SDs) above the mean of pre-immune sera at a 1:100 dilution. Antibody responses to RSV F protein were induced by ChAd155-RSV and maintained over a period of 10 weeks after a single IM administration of 5×10 8  vp, and antibody titers were 1.5-fold higher at plateau than those induced by PanAd3-RSV ( FIG. 15 ). 
     5.2.2—Cotton Rats 
     Methodology 
     Five groups of female, 6-8 weeks old cotton rats (8 rats/group) were immunized by the intramusculat (IM) route with 5×10 8  or 5×10 7  vp of ChAd155-RSV or PanAd3-RSV (see Table 5). A control group was left unvaccinated. Seven weeks after vaccination, the animals were challenged by intranasal (IN) inoculation with a 10 5  pfu standard dose of RSV A (Long strain). Five days after challenge, the animals were sacrificed, the nasal tissue harvested for viral titration, and the lung en bloc collected and bisected for viral titration (left lobes) and histopathology (right lobes, Groups A, D, E only). RSV titers in nasal tissue or lung homogenates collected five days after RSV challenge were determined by a standard plaque assay on permissive cells (HEp-2 cells). FFPE lung sections were stained with Hematoxylin/Eosin. Four parameters of pulmonary inflammation were evaluated: peribronchiolitis (PB), perivasculitis (PV), interstitial pneumonia (IP), and alveolitis (A). Slides were scored blind on a 0-4 severity scale, and values were then converted to a 0-100% histopathology score. The animals were also bled at Day 0 and at the time of challenge, for RSV neutralizing antibody titration by standard plaque assay on permissive cells (Vero cells). Neutralizing antibody titers were determined as the reciprocal of the serum dilutions at which 60% of the virus was neutralized compared to virus control. 
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 Dosing scheme of cotton rats 
               
            
           
           
               
               
               
               
            
               
                   
                 Group 
                 Vaccine 
                 Immunization dose 
               
               
                   
                   
               
               
                   
                 A 
                 Control 
                 — 
               
               
                   
                 B 
                 PanAd3-RSV IM 
                 5 × 10 8  vp 
               
               
                   
                 C 
                 PanAd3-RSV IM 
                 5 × 10 7  vp 
               
               
                   
                 D 
                 ChAd155-RSV IM 
                 5 × 10 8  vp 
               
               
                   
                 E 
                 ChAd155-RSV IM 
                 5 × 10 7  vp 
               
               
                   
                   
               
            
           
         
       
     
     Immunogenicity and Efficacy Results 
       FIG. 16  panels A and B show the RSV viral titers from nasal tissue and lung homogenates, respectively, by plaque assay. RSV titers in nasal tissue or lung homogenates collected five days after RSV challenge were determined by a standard plaque assay on permissive cells. Data are expressed as RSV plaque forming units per gram of tissue (pfu/g). intramuscular ChAd155-RSV at both dosages completely abolished viral replication in the lung, apart from one animal at the lowest dosage. Infection of the upper respiratory tract was also significantly reduced (between 1 and 2 logs lower RSV titers recovered from nasal tissue) in a dose-dependent manner compared to unvaccinated control animals. 
     It has been previously shown that in cotton rats a serum neutralizing antibody titer of 1:100 or greater confers protection from viral replication in the lung [Prince, 1985]. In this study both vectors administered IM at 5×10 8  vp induced RSV neutralizing antibodies in the range of the protective threshold while titers decreased with a lower vaccine dosage ( FIG. 16  panel C). Nevertheless, the vaccination prevented viral replication in the lung even when serum antibody levels were below 1:100, suggesting a role for other immune effector mechanisms. RSV neutralizing antibody titers are expressed as the serum dilution reducing plaques by 60% compared to control. 
     Safety Results 
     Lung histopathology was performed five days post-infection to assess whether vaccination with ChAd155-RSV induced vaccine-enhanced pathology. Four parameters of pulmonary inflammation were evaluated according to the presence of inflammatory cells in different areas of the lung structure: peribronchiolitis (PB, inflammatory cell infiltration around the bronchioles), perivasculitis (PV, inflammatory cell infiltration around the small blood vessels), interstitial pneumonia (IP, inflammatory cell infiltration and thickening of alveolar walls), and alveolitis (A, cells within the alveolar space). Formalin-fixed, paraffin-embedded lung sections were stained with Hematoxylin/Eosin. Slides were scored blind on a 0-4 severity scale, and values were then converted to a 0-100% histopathology score. The dashed line (set at 5%) represents the threshold for significant pathology. Histopathology data for PanAd3-RSV (depicted in grey) derive from a previous study. Among the four parameters, the presence of inflammatory infiltrate in the alveolar walls (interstitial pneumonia [IP]), and more importantly in the alveolar space, (alveolitis [A]), is considered predictive for enhanced disease and lung pathology [Prince, 2001]. The results of the lung histopathology analysis ( FIG. 16  panel D) showed that IM ChAd155-RSV did not induce significant IP and A pathology scores. The low levels of IP and A observed were consistent with what has been observed during RSV acute infection and secondary RSV re-infection [American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis.  Pediatrics.  2006; 118: 1774-93. 
     Boukhvalova, 2013], and were comparable to values observed with PanAd3-RSV in previous studies. 
     In  FIG. 16 , dashed horizontal lines represent limit of detection (LOD) for each assay in panels A, B and C. In panel D The dashed horizontal line (set at 5%) represents the threshold for significant pathology. 
     5.2.3—Seronegative Calves 
     Bovine RSV (bRSV) causes respiratory disease in young calves that is very similar to that observed in human infants. In addition, bovine RSV is genetically and antigenically related to human RSV. The newborn calf bRSV model a relevant animal model for evaluation of safety of human RSV vaccines 
     Methodology 
     Three groups of five colostrum-restricted calves were vaccinated on two occasions, four weeks apart, with 5×10 10  vp ChAd155-RSV or comparator PanAd3-RSV, as indicated in Table 6. 
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 Dosing scheme of newborn calves 
               
            
           
           
               
               
               
               
               
            
               
                 Group 
                 Vaccination 1 
                 Dose 
                 Vaccination 2 
                 Dose 
               
               
                   
               
               
                 A 
                 PanAd3-RSV IM 
                 5 × 10 10  vp 
                 PanAd3-RSV IM 
                 5 × 10 10  vp 
               
               
                 B 
                 ChAd155-RSV IM 
                 5 × 10 10  vp 
                 ChAd155-RSV IM 
                 5 × 10 10  vp 
               
               
                 C 
                 PanAd3-control IM 
                 5 × 10 10  vp 
                 PanAd3-control IM 
                 5 × 10 10  vp 
               
               
                   
               
            
           
         
       
     
     Group C was mock-vaccinated with PanAd3 adenovectors containing unrelated antigens. The animals were challenged four weeks after the second vaccination by IN (10 mL) and intratracheal (IT) (10 mL) administration of 10 4  pfu of bRSV Snook strain. Six days after the infection, when the virus replication peaked in the lung and in the nose causing maximal pulmonary pathology, the animals were sacrificed. In this model, due to the IN/IT routes of administration of the challenge inoculum, very few, if any, clinical signs are observed in challenged control animals. Therefore, the effects of vaccination on bRSV challenge were studied by nasopharyngeal excretion of bRSV, analysis of levels of bRSV in lung homogenate, development of gross pneumonic lesions and analysis of leukocytes in broncho-alveolar lavage (BAL). Antibody responses (antibody and neutralizing titers) induced after vaccination and/or challenge were also investigated. 
     Immunogenicity Results 
     Effect of Vaccination on Induction of bRSV-Specific Serum IgG 
     Kinetics of the mean bRSV-specific serum IgG antibody and human RSV (hRSV) neutralizing titers throughout the course of the vaccination are shown per study group in  FIG. 17 . The graph shows the geometric mean value of each study group. Levels of bRSV-specific IgG were determined using bRSV (Snook strain)-infected fetal calf kidney (FCK) cell lysate as antigen [Taylor, 1995]. A lysate of mock-infected FCK cells was used as a control antigen. 
     Two out of five animals in each group receiving an RSV immunogen showed low levels of maternal bRSV-specific antibodies at the start of the vaccination. Nevertheless, all animals responded to the vaccines and reached high levels (log 10 =3-3.5) of bRSV-specific antibodies after the boost ( FIG. 17A ). All the calves in the control group had detectable bRSV-specific antibodies at the start of the vaccination which declined during the study and were not detectable on the day of the challenge. In conclusion, PanAd3-RSV and ChAd155-RSV displayed similar potency in eliciting antibody responses. 
     No hRSV neutralizing response could be detected before vaccination. After a single dose, all animals vaccinated with PanAd3-RSV and 2 out of 5 animals vaccinated with ChAd155-RSV had measurable RSV neutralizing antibodies ( FIG. 17B ). A marked boost was observed after the second dose for both vaccines. No further enhancement of the hRSV neutralizing response was observed 1 week after challenge. 
     Efficacy Results 
     Effect of Vaccination on Nasopharyngeal Excretion of bRSV 
     Following bRSV challenge, nasopharynx swabs were obtained daily and the bRSV titers within the samples determined. As shown in  FIG. 18 , titers in the control group increased from day 3 to day 6. bRSV replication appeared to be significantly reduced in calves that had received either of the adenovector RSV constructs. 
     Effect of Vaccination on Replication of bRSV in the Lower Respiratory Tract. 
     Six days after bRSV challenge, high titers of bRSV were detected in lung wash cells (LWC) and lung lobe homogenates (RA, RC and LC) of all of the control calves, and from tracheal scrape (TSc) samples in 5 out of 6 of the control calves ( FIG. 19 ). In contrast, bRSV was detected at low titers from the TSc samples of 2 and from LWC of 1 of the calves which received ChAd155-RSV, while it was undetectable in all samples from the calves which received PanAd3-RSV. 
     Effect of Vaccination on Pulmonary Pathology 
     Six days after bRSV challenge, extensive gross pneumonic consolidation was observed in 6 out of 6 control calves ( FIG. 20 ). In contrast, there was little or no gross pneumonic consolidation in the calves that had received either of the adenovector RSV constructs.  FIG. 21  quantifies the mean proportion±SD of lymphocytes (L), macrophages (Mo), polymorphonuclear leukocytes (PMN) and eosinophils (Eo) in BAL, 6 days after bRSV challenge. Approximately 70% of the cells in BAL from control calves were PMN. A lower proportion of PMN was found in BAL from calves which received ChAd155-RSV or PanAd3-RSV, indicating a reduced pulmonary inflammation. Importantly, eosinophils were very few or undetectable in the lungs of calves which received ChAd155-RSV or PanAd3-RSV suggesting the absence of vaccine-induced disease exacerbation. 
     Conclusion 
     Taken together the results reported above demonstrated that ChAd155 is an improved adenoviral vector in comparison to ChAd3 and PanAd3 vectors. ChAd155 was shown to be more productive therefore facilitating the manufacture process, able to express higher level of transgene in vitro and also in vivo providing a stronger T-cell response and at least as potent an antibody response against the antigens expressed in animal models. Protective immunity is achieved without signs of vaccine-induced enhanced pulmonary pathology. 
     REFERENCES 
     American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis.  Pediatrics.  2006; 118: 1774-93. 
     Boukhvalova M S and Blanco J C. The cotton rat Sigmodon hyspidus model of respiratory syncytial virus infection.  Curr Top Microbiol Immunol.  2013; 372: 347-58. 
     Cardenas S, Auais A and Piedimonte G. Palivizumab in the prophylaxis of respiratory syncytial virus infection.  Expert Rev Anti Infect Ther.  2005; 3(5): 719-26. 
     Castilow E M and Varga S M. Overcoming T cell-mediated immunopathology to achieve safe RSV vaccination.  Future Virol.  2008; 3(5): 445-454. 
     Chin J, Magoffin R L, Shearer L A, et al., Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population.  Am J Epidemiol.  1969; 89(4): 449-63. 
     Colloca S, Barnes E, Folgori A, et al., Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species.  Sci Transl Med.  2012; 4(115): p. 115ra2. 
     Donnelly M L, Luke G, Mehrotra A, et al., Analysis of the aphthovirus 2A/2B polyprotein ‘cleavage’ mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal ‘skip’.  J Gen Virol.  2001; 82(Pt 5): 1013-25. 
     Fallaux, F J et al, (1998), Hum Gene Ther, 9:1909-1917 
     Guvenel A K, Chiu C and Openshaw P J. Current concepts and progress in RSV vaccine development.  Expert Rev Vaccines.  2014; 13(3): 333-44. 
     Hertz, M I, Englund J A, Snover D, et al., Respiratory syncytial virus-induced acute lung injury in adult patients with bone marrow transplants: a clinical approach and review of the literature.  Medicine  (Baltimore). 1989; 68(5): 269-81. 
     Kim H W, Canchola J G, Brandt C D et al., Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine.  Am J Epidemiol.  1969; 89(4): 422-34. 
     Magro M, Andreu D, Gómez-Puertas P, et al., Neutralization of human respiratory syncytial virus infectivity by antibodies and low-molecular-weight compounds targeted against the fusion glycoprotein.  J Virol.  2010; 84(16): 7970-82. 
     Piedra P A, Jewell A M, Cron S G, et al., Correlates of immunity to respiratory syncytial virus (RSV) associated-hospitalization: establishment of minimum protective threshold levels of serum neutralizing antibodies.  Vaccine.  2003; 21(24): 3479-82. 
     Prince G A, Curtis S J, Yim K C, et al., Vaccine-enhanced respiratory syncytial virus disease in cotton rats following immunization with Lot 100 or a newly prepared reference vaccine.  J. Gen. Virol.  2001; 82: 2881-88. 
     Prince G A, Horswood R L and Chanock R M. Quantitative aspects of passive immunity to respiratory syncytial virus infection in infant cotton rats.  J Virol.  1985; 55(3): 517-20. 
     Stevens W W, Sun J, Castillo J P, et al., Pulmonary eosinophilia is attenuated by early responding CD8(+) memory T cells in a murine model of RSV vaccine-enhanced disease.  Viral Immunol.  2009; 22(4): 243-51. 
     Taylor G, Thomas L H, Wyld S G, et al., Role of T-lymphocyte subsets in recovery from respiratory syncytial virus infection in calves.  J Virol.  1995; 69(11): 6658-64. 
     Townsend A R and Skehel J J. The influenza A virus nucleoprotein gene controls the induction of both subtype specific and cross-reactive cytotoxic T cells.  J Exp Med.  1984; 160(2): 552-63. 
     Welliver T P, Garofalo R P, Hosakote Y, et al., Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses.  J Infect Dis.  2007. 195(8): 1126-36. 
     
       
         
           
               
               
            
               
                 DESCRIPTION OF THE SEQUENCES 
                   
               
               
                 Polypeptide sequence of ChAd155 fiber 
               
               
                 SEQ ID NO: 1 
                   
               
               
                 MKRTKTSDESFNPVYPYDTESGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS 
                   
               
               
                   
               
               
                 LDDAGNLTSQDITTASPPLKKTKTNLSLETSSPLTVSTSGALTVAAAAPLAVAGTSLTMQSEAPLTVQDAK 
               
               
                   
               
               
                 LTLATKGPLTVSEGKLALQTSAPLTAADSSTLTVSATPPLSTSNGSLGIDMQAPIYTTNGKLGLNFGAPLH 
               
               
                   
               
               
                 VVDSLNALTVVTGQGLTINGTALQTRVSGALNYDTSGNLELRAAGGMRVDANGQLILDVAYPFDAQNN 
               
               
                   
               
               
                 LSLRLGQGPLFVNSAHNLDVNYNRGLYLFTSGNTKKLEVNIKTAKGLIYDDTAIAINAGDGLQFDSGSDT 
               
               
                   
               
               
                 NPLKTKLGLGLDYDSSRAIIAKLGTGLSFDNTGAITVGNKNDDKLTLWTTPDPSPNCRIYSEKDAKFTLVL 
               
               
                   
               
               
                 TKCGSQVLASVSVLSVKGSLAPISGTVTSAQIVLRFDENGVLLSNSSLDPQYWNYRKGDLTEGTAYTNAV 
               
               
                   
               
               
                 GFMPNLTAYPKTQSQTAKSNIVSQVYLNGDKSKPMTLTITLNGTNETGDATVSTYSMSFSWNWNGSNYI 
               
               
                   
               
               
                 NETFQTNSFTFSYIAQE 
               
               
                   
               
               
                 Polynucleotide sequence encoding ChAd155 fiber 
               
               
                 SEQ ID NO: 2 
                   
               
               
                 ATGAAGCGCACCAAAACGTCTGACGAGAGCTTCAACCCCGTGTACCCCTATGACACGGAAAGCGGCC 
                   
               
               
                   
               
               
                 CTCCCTCCGTCCCTTTCCTCACCCCTCCCTTCGTGTCTCCCGATGGATTCCAAGAAAGTCCCCCCGGGG 
               
               
                   
               
               
                 TCCTGTCTCTGAACCTGGCCGAGCCCCTGGTCACTTCCCACGGCATGCTCGCCCTGAAAATGGGAAGT 
               
               
                   
               
               
                 GGCCTCTCCCTGGACGACGCTGGCAACCTCACCTCTCAAGATATCACCACCGCTAGCCCTCCCCTCAA 
               
               
                   
               
               
                 AAAAACCAAGACCAACCTCAGCCTAGAAACCTCATCCCCCCTAACTGTGAGCACCTCAGGCGCCCTC 
               
               
                   
               
               
                 ACCGTAGCAGCCGCCGCTCCCCTGGCGGTGGCCGGCACCTCCCTCACCATGCAATCAGAGGCCCCCC 
               
               
                   
               
               
                 TGACAGTACAGGATGCAAAACTCACCCTGGCCACCAAAGGCCCCCTGACCGTGTCTGAAGGCAAACT 
               
               
                   
               
               
                 GGCCTTGCAAACATCGGCCCCGCTGACGGCCGCTGACAGCAGCACCCTCACAGTCAGTGCCACACCA 
               
               
                   
               
               
                 CCCCTTAGCACAAGCAATGGCAGCTTGGGTATTGACATGCAAGCCCCCATTTACACCACCAATGGAA 
               
               
                   
               
               
                 AACTAGGACTTAACTTTGGCGCTCCCCTGCATGTGGTAGACAGCCTAAATGCACTGACTGTAGTTACT 
               
               
                   
               
               
                 GGCCAAGGTCTTACGATAAACGGAACAGCCCTACAAACTAGAGTCTCAGGTGCCCTCAACTATGACA 
               
               
                   
               
               
                 CATCAGGAAACCTAGAATTGAGAGCTGCAGGGGGTATGCGAGTTGATGCAAATGGTCAACTTATCCT 
               
               
                   
               
               
                 TGATGTAGCTTACCCATTTGATGCACAAAACAATCTCAGCCTTAGGCTTGGACAGGGACCCCTGTTTG 
               
               
                   
               
               
                 TTAACTCTGCCCACAACTTGGATGTTAACTACAACAGAGGCCTCTACCTGTTCACATCTGGAAATACC 
               
               
                   
               
               
                 AAAAAGCTAGAAGTTAATATCAAAACAGCCAAGGGTCTCATTTATGATGACACTGCTATAGCAATCA 
               
               
                   
               
               
                 ATGCGGGTGATGGGCTACAGTTTGACTCAGGCTCAGATACAAATCCATTAAAAACTAAACTTGGATT 
               
               
                   
               
               
                 AGGACTGGATTATGACTCCAGCAGAGCCATAATTGCTAAACTGGGAACTGGCCTAAGCTTTGACAAC 
               
               
                   
               
               
                 ACAGGTGCCATCACAGTAGGCAACAAAAATGATGACAAGCTTACCTTGTGGACCACACCAGACCCAT 
               
               
                   
               
               
                 CCCCTAACTGTAGAATCTATTCAGAGAAAGATGCTAAATTCACACTTGTTTTGACTAAATGCGGCAGT 
               
               
                   
               
               
                 CAGGTGTTGGCCAGCGTTTCTGTTTTATCTGTAAAAGGTAGCCTTGCGCCCATCAGTGGCACAGTAAC 
               
               
                   
               
               
                 TAGTGCTCAGATTGTCCTCAGATTTGATGAAAATGGAGTTCTACTAAGCAATTCTTCCCTTGACCCTC 
               
               
                   
               
               
                 AATACTGGAACTACAGAAAAGGTGACCTTACAGAGGGCACTGCATATACCAACGCAGTGGGATTTAT 
               
               
                   
               
               
                 GCCCAACCTCACAGCATACCCAAAAACACAGAGCCAAACTGCTAAAAGCAACATTGTAAGTCAGGTT 
               
               
                   
               
               
                 TACTTGAATGGGGACAAATCCAAACCCATGACCCTCACCATTACCCTCAATGGAACTAATGAAACAG 
               
               
                   
               
               
                 GAGATGCCACAGTAAGCACTTACTCCATGTCATTCTCATGGAACTGGAATGGAAGTAATTACATTAA 
               
               
                   
               
               
                 TGAAACGTTCCAAACCAACTCCTTCACCTTCTCCTACATCGCCCAAGAA 
               
               
                   
               
               
                 Polypeptide sequence of ChAd155 penton 
               
               
                 SEQ ID NO: 3 
                   
               
               
                 MRRAAMYQEGPPPSYESVVGAAAAAPSSPFASQLLEPPYVPPRYLRPTGGRNSIRYSELAPLFDTTRVYLV 
                   
               
               
                   
               
               
                 DNKSADVASLNYQNDHSNFLTTVIQNNDYSPSEASTQTINLDDRSHWGGDLKTILHTNMPNVNEFMFTN 
               
               
                   
               
               
                 KFKARVMVSRSHTKEDRVELKYEWVEFELPEGNYSETMTIDLMNNAIVEHYLKVGRQNGVLESDIGVKF 
               
               
                   
               
               
                 DTRNFRLGLDPVTGLVMPGVYTNEAFHPDIILLPGCGVDFTYSRLSNLLGIRKRQPFQEGFRITYEDLEGG 
               
               
                   
               
               
                 NIPALLDVEAYQDSLKENEAGQEDTAPAASAAAEQGEDAADTAAADGAEADPAMVVEAPEQEEDMNDS 
               
               
                   
               
               
                 AVRGDTFVTRGEEKQAEAEAAAEEKQLAAAAAAAALAAAEAESEGTKPAKEPVIKPLTEDSKKRSYNLL 
               
               
                   
               
               
                 KDSTNTAYRSWYLAYNYGDPSTGVRSWTLLCTPDVTCGSEQVYWSLPDMMQDPVTFRSTRQVSNFPVV 
               
               
                   
               
               
                 GAELLPVHSKSFYNDQAVYSQLIRQFTSLTHVFNRFPENQILARPPAPTITTVSENVPALTDHGTLPLRNSIG 
               
               
                   
               
               
                 GVQRVTVTDARRRTCPYVYKALGIVSPRVLSSRTF 
               
               
                   
               
               
                 Polynucleotide sequence encoding ChAd155 penton 
               
               
                 SEQ ID NO: 4 
                   
               
               
                 ATGCGGCGCGCGGCGATGTACCAGGAGGGACCTCCTCCCTCTTACGAGAGCGTGGTGGGCGCGGCGG 
                   
               
               
                   
               
               
                 CGGCGGCGCCCTCTTCTCCCTTTGCGTCGCAGCTGCTGGAGCCGCCGTACGTGCCTCCGCGCTACCTG 
               
               
                   
               
               
                 CGGCCTACGGGGGGGAGAAACAGCATCCGTTACTCGGAGCTGGCGCCCCTGTTCGACACCACCCGGG 
               
               
                   
               
               
                 TGTACCTGGTGGACAACAAGTCGGCGGACGTGGCCTCCCTGAACTACCAGAACGACCACAGCAATTT 
               
               
                   
               
               
                 TTTGACCACGGTCATCCAGAACAATGACTACAGCCCGAGCGAGGCCAGCACCCAGACCATCAATCTG 
               
               
                   
               
               
                 GATGACCGGTCGCACTGGGGCGGCGACCTGAAAACCATCCTGCACACCAACATGCCCAACGTGAAC 
               
               
                   
               
               
                 GAGTTCATGTTCACCAATAAGTTCAAGGCGCGGGTGATGGTGTCGCGCTCGCACACCAAGGAAGACC 
               
               
                   
               
               
                 GGGTGGAGCTGAAGTACGAGTGGGTGGAGTTCGAGCTGCCAGAGGGCAACTACTCCGAGACCATGA 
               
               
                   
               
               
                 CCATTGACCTGATGAACAACGCGATCGTGGAGCACTATCTGAAAGTGGGCAGGCAGAACGGGGTCCT 
               
               
                   
               
               
                 GGAGAGCGACATCGGGGTCAAGTTCGACACCAGGAACTTCCGCCTGGGGCTGGACCCCGTGACCGG 
               
               
                   
               
               
                 GCTGGTTATGCCCGGGGTGTACACCAACGAGGCCTTCCATCCCGACATCATCCTGCTGCCCGGCTGCG 
               
               
                   
               
               
                 GGGTGGACTTCACTTACAGCCGCCTGAGCAACCTCCTGGGCATCCGCAAGCGGCAGCCCTTCCAGGA 
               
               
                   
               
               
                 GGGCTTCAGGATCACCTACGAGGACCTGGAGGGGGGCAACATCCCCGCGCTCCTCGATGTGGAGGCC 
               
               
                   
               
               
                 TACCAGGATAGCTTGAAGGAAAATGAGGCGGGACAGGAGGATACCGCCCCCGCCGCCTCCGCCGCC 
               
               
                   
               
               
                 GCCGAGCAGGGCGAGGATGCTGCTGACACCGCGGCCGCGGACGGGGCAGAGGCCGACCCCGCTATG 
               
               
                   
               
               
                 GTGGTGGAGGCTCCCGAGCAGGAGGAGGACATGAATGACAGTGCGGTGCGCGGAGACACCTTCGTC 
               
               
                   
               
               
                 ACCCGGGGGGAGGAAAAGCAAGCGGAGGCCGAGGCCGCGGCCGAGGAAAAGCAACTGGCGGCAGC 
               
               
                   
               
               
                 AGCGGCGGCGGCGGCGTTGGCCGCGGCGGAGGCTGAGTCTGAGGGGACCAAGCCCGCCAAGGAGCC 
               
               
                   
               
               
                 CGTGATTAAGCCCCTGACCGAAGATAGCAAGAAGCGCAGTTACAACCTGCTCAAGGACAGCACCAA 
               
               
                   
               
               
                 CACCGCGTACCGCAGCTGGTACCTGGCCTACAACTACGGCGACCCGTCGACGGGGGTGCGCTCCTGG 
               
               
                   
               
               
                 ACCCTGCTGTGCACGCCGGACGTGACCTGCGGCTCGGAGCAGGTGTACTGGTCGCTGCCCGACATGA 
               
               
                   
               
               
                 TGCAAGACCCCGTGACCTTCCGCTCCACGCGGCAGGTCAGCAACTTCCCGGTGGTGGGCGCCGAGCT 
               
               
                   
               
               
                 GCTGCCCGTGCACTCCAAGAGCTTCTACAACGACCAGGCCGTCTACTCCCAGCTCATCCGCCAGTTCA 
               
               
                   
               
               
                 CCTCTCTGACCCACGTGTTCAATCGCTTTCCTGAGAACCAGATTCTGGCGCGCCCGCCCGCCCCCACC 
               
               
                   
               
               
                 ATCACCACCGTCAGTGAAAACGTTCCTGCTCTCACAGATCACGGGACGCTACCGCTGCGCAACAGCA 
               
               
                   
               
               
                 TCGGAGGAGTCCAGCGAGTGACCGTTACTGACGCCAGACGCCGCACCTGCCCCTACGTTTACAAGGC 
               
               
                   
               
               
                 CTTGGGCATAGTCTCGCCGCGCGTCCTTTCCAGCCGCACTTTT 
               
               
                   
               
               
                 Polypeptide sequence of ChAd155 hexon 
               
               
                 SEQ ID NO: 5 
                   
               
               
                 MATPSMMPQWSYMHISGQDASEYLSPGLVQFARATDSYFSLSNKFRNPTVAPTHDVTTDRSQRLTLRFIP 
                   
               
               
                   
               
               
                 VDREDTAYSYKARFTLAVGDNRVLDMASTYFDIRGVLDRGPTFKPYSGTAYNSLAPKGAPNSCEWEQEE 
               
               
                   
               
               
                 TQTAEEAQDEEEDEAEAEEEMPQEEQAPVKKTHVYAQAPLSGEKITKDGLQIGTDATATEQKPIYADPTF 
               
               
                   
               
               
                 QPEPQIGESQWNEADASVAGGRVLKKTTPMKPCYGSYARPTNANGGQGVLVEKDGGKMESQVDMQFFS 
               
               
                   
               
               
                 TSENARNEANNIQPKLVLYSEDVHMETPDTHISYKPAKSDDNSKVMLGQQSMPNRPNYIGFRDNFIGLMY 
               
               
                   
               
               
                 YNSTGNMGVLAGQASQLNAVVDLQDRNTELSYQLLLDSMGDRTRYFSMWNQAVDSYDPDVRIIENHGT 
               
               
                   
               
               
                 EDELPNYCFPLGGIGVTDTYQAIKTNGNGNGGGNTTWTKDETFADRNEIGVGNNFAMEINLSANLWRNF 
               
               
                   
               
               
                 LYSNVALYLPDKLKYNPSNVEISDNPNTYDYMNKRVVAPGLVDCYINLGARWSLDYMDNVNPFNHHRN 
               
               
                   
               
               
                 AGLRYRSMLLGNGRYVPFHIQVPQKFFAIKNLLLLPGSYTYEWNFRKDVNMVLQSSLGNDLRVDGASIKF 
               
               
                   
               
               
                 ESICLYATFFPMAHNTASTLEAMLRNDTNDQSFNDYLSAANMLYPIPANATNVPISIPSRNWAAFRGWAF 
               
               
                   
               
               
                 TRLKTKETPSLGSGFDPYYTYSGSIPYLDGTFYLNHTFKKVSVTFDSSVSWPGNDRLLTPNEFEIKRSVDGE 
               
               
                   
               
               
                 GYNVAQCNMTKDWFLIQMLANYNIGYQGFYIPESYKDRMYSFFRNFQPMSRQVVDETKYKDYQQVGII 
               
               
                   
               
               
                 HQHNNSGFVGYLAPTMREGQAYPANFPYPLIGKTAVDSVTQKKFLCDRTLWRIPFSSNFMSMGALTDLG 
               
               
                   
               
               
                 QNLLYANSAHALDMTFEVDPMDEPTLLYVLFEVFDVVRVHQPHRGVIETVYLRTPFSAGNATT 
               
               
                   
               
               
                 Polynucleotide sequence encoding ChAd155 hexon 
               
               
                 SEQ ID NO: 6 
                   
               
               
                 ATGGCGACCCCATCGATGATGCCGCAGTGGTCGTACATGCACATCTCGGGCCAGGACGCCTCGGAGT 
                   
               
               
                   
               
               
                 ACCTGAGCCCCGGGCTGGTGCAGTTCGCCCGCGCCACCGAGAGCTACTTCAGCCTGAGTAACAAGTT 
               
               
                   
               
               
                 TAGGAACCCCACGGTGGCGCCCACGCACGATGTGACCACCGACCGGTCTCAGCGCCTGACGCTGCGG 
               
               
                   
               
               
                 TTCATTCCCGTGGACCGCGAGGACACCGCGTACTCGTACAAGGCGCGGTTCACCCTGGCCGTGGGCG 
               
               
                   
               
               
                 ACAACCGCGTGCTGGACATGGCCTCCACCTACTTTGACATCCGCGGGGTGCTGGACCGGGGTCCCAC 
               
               
                   
               
               
                 TTTCAAGCCCTACTCTGGCACCGCCTACAACTCCCTGGCCCCCAAGGGCGCTCCCAACTCCTGCGAGT 
               
               
                   
               
               
                 GGGAGCAAGAGGAAACTCAGGCAGTTGAAGAAGCAGCAGAAGAGGAAGAAGAAGATGCTGACGGT 
               
               
                   
               
               
                 CAAGCTGAGGAAGAGCAAGCAGCTACCAAAAAGACTCATGTATATGCTCAGGCTCCCCTTTCTGGCG 
               
               
                   
               
               
                 AAAAAATTAGTAAAGATGGTCTGCAAATAGGAACGGACGCTACAGCTACAGAACAAAAACCTATTT 
               
               
                   
               
               
                 ATGCAGACCCTACATTCCAGCCCGAACCCCAAATCGGGGAGTCCCAGTGGAATGAGGCAGATGCTAC 
               
               
                   
               
               
                 AGTCGCCGGCGGTAGAGTGCTAAAGAAATCTACTCCCATGAAACCATGCTATGGTTCCTATGCAAGA 
               
               
                   
               
               
                 CCCACAAATGCTAATGGAGGTCAGGGTGTACTAACGGCAAATGCCCAGGGACAGCTAGAATCTCAG 
               
               
                   
               
               
                 GTTGAAATGCAATTCTTTTCAACTTCTGAAAACGCCCGTAACGAGGCTAACAACATTCAGCCCAAATT 
               
               
                   
               
               
                 GGTGCTGTATAGTGAGGATGTGCACATGGAGACCCCGGATACGCACCTTTCTTACAAGCCCGCAAAA 
               
               
                   
               
               
                 AGCGATGACAATTCAAAAATCATGCTGGGTCAGCAGTCCATGCCCAACAGACCTAATTACATCGGCT 
               
               
                   
               
               
                 TCAGAGACAACTTTATCGGCCTCATGTATTACAATAGCACTGGCAACATGGGAGTGCTTGCAGGTCA 
               
               
                   
               
               
                 GGCCTCTCAGTTGAATGCAGTGGTGGACTTGCAAGACAGAAACACAGAACTGTCCTACCAGCTCTTG 
               
               
                   
               
               
                 CTTGATTCCATGGGTGACAGAACCAGATACTTTTCCATGTGGAATCAGGCAGTGGACAGTTATGACC 
               
               
                   
               
               
                 CAGATGTTAGAATTATTGAAAATCATGGAACTGAAGACGAGCTCCCCAACTATTGTTTCCCTCTGGGT 
               
               
                   
               
               
                 GGCATAGGGGTAACTGACACTTACCAGGCTGTTAAAACCAACAATGGCAATAACGGGGGCCAGGTG 
               
               
                   
               
               
                 ACTTGGACAAAAGATGAAACTTTTGCAGATCGCAATGAAATAGGGGTGGGAAACAATTTCGCTATGG 
               
               
                   
               
               
                 AGATCAACCTCAGTGCCAACCTGTGGAGAAACTTCCTGTACTCCAACGTGGCGCTGTACCTACCAGA 
               
               
                   
               
               
                 CAAGCTTAAGTACAACCCCTCCAATGTGGACATCTCTGACAACCCCAACACCTACGATTACATGAAC 
               
               
                   
               
               
                 AAGCGAGTGGTGGCCCCGGGGCTGGTGGACTGCTACATCAACCTGGGCGCGCGCTGGTCGCTGGACT 
               
               
                   
               
               
                 ACATGGACAACGTCAACCCCTTCAACCACCACCGCAATGCGGGCCTGCGCTACCGCTCCATGCTCCT 
               
               
                   
               
               
                 GGGCAACGGGCGCTACGTGCCCTTCCACATCCAGGTGCCCCAGAAGTTCTTTGCCATCAAGAACCTC 
               
               
                   
               
               
                 CTCCTCCTGCCGGGCTCCTACACCTACGAGTGGAACTTCAGGAAGGATGTCAACATGGTCCTCCAGA 
               
               
                   
               
               
                 GCTCTCTGGGTAACGATCTCAGGGTGGACGGGGCCAGCATCAAGTTCGAGAGCATCTGCCTCTACGC 
               
               
                   
               
               
                 CACCTTCTTCCCCATGGCCCACAACACGGCCTCCACGCTCGAGGCCATGCTCAGGAACGACACCAAC 
               
               
                   
               
               
                 GACCAGTCCTTCAATGACTACCTCTCCGCCGCCAACATGCTCTACCCCATACCCGCCAACGCCACCAA 
               
               
                   
               
               
                 CGTCCCCATCTCCATCCCCTCGCGCAACTGGGCGGCCTTCCGCGGCTGGGCCTTCACCCGCCTCAAGA 
               
               
                   
               
               
                 CCAAGGAGACCCCCTCCCTGGGCTCGGGATTCGACCCCTACTACACCTACTCGGGCTCCATTCCCTAC 
               
               
                   
               
               
                 CTGGACGGCACCTTCTACCTCAACCACACTTTCAAGAAGGTCTCGGTCACCTTCGACTCCTCGGTCAG 
               
               
                   
               
               
                 CTGGCCGGGCAACGACCGTCTGCTCACCCCCAACGAGTTCGAGATCAAGCGCTCGGTCGACGGGGAG 
               
               
                   
               
               
                 GGCTACAACGTGGCCCAGTGCAACATGACCAAGGACTGGTTCCTGGTCCAGATGCTGGCCAACTACA 
               
               
                   
               
               
                 ACATCGGCTACCAGGGCTTCTACATCCCAGAGAGCTACAAGGACAGGATGTACTCCTTCTTCAGGAA 
               
               
                   
               
               
                 CTTCCAGCCCATGAGCCGGCAGGTGGTGGACCAGACCAAGTACAAGGACTACCAGGAGGTGGGCAT 
               
               
                   
               
               
                 CATCCACCAGCACAACAACTCGGGCTTCGTGGGCTACCTCGCCCCCACCATGCGCGAGGGACAGGCC 
               
               
                   
               
               
                 TACCCCGCCAACTTCCCCTATCCGCTCATAGGCAAGACCGCGGTCGACAGCATCACCCAGAAAAAGT 
               
               
                   
               
               
                 TCCTCTGCGACCGCACCCTCTGGCGCATCCCCTTCTCCAGCAACTTCATGTCCATGGGTGCGCTCTCG 
               
               
                   
               
               
                 GACCTGGGCCAGAACTTGCTCTACGCCAACTCCGCCCACGCCCTCGACATGACCTTCGAGGTCGACC 
               
               
                   
               
               
                 CCATGGACGAGCCCACCCTTCTCTATGTTCTGTTCGAAGTCTTTGACGTGGTCCGGGTCCACCAGCCG 
               
               
                   
               
               
                 CACCGCGGCGTCATCGAGACCGTGTACCTGCGTACGCCCTTCTCGGCCGGCAACGCCACCACC 
               
               
                   
               
               
                 Polynucleotide sequence encoding ChAd155#1434 backbone construct 
               
               
                 SEQ ID NO: 7 
                   
               
               
                 CATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGATGGGCGGCGCGGGGCG 
                   
               
               
                   
               
               
                 GGGCGCGGGGCGGGAGGCGGGTTTGGGGGCGGGCCGGCGGGCGGGGCGGTGTGGCGGAAGTGGAC 
               
               
                   
               
               
                 TTTGTAAGTGTGGCGGATGTGACTTGCTAGTGCCGGGCGCGGTAAAAGTGACGTTTTCCGTGCGCGA 
               
               
                   
               
               
                 CAACGCCCCCGGGAAGTGACATTTTTCCCGCGGTTTTTACCGGATGTTGTAGTGAATTTGGGCGTAAC 
               
               
                   
               
               
                 CAAGTAAGATTTGGCCATTTTCGCGGGAAAACTGAAACGGGGAAGTGAAATCTGATTAATTTTGCGT 
               
               
                   
               
               
                 TAGTCATACCGCGTAATATTTGTCTAGGGCCGAGGGACTTTGGCCGATTACGTGGAGGACTCGCCCA 
               
               
                   
               
               
                 GGTGTTTTTTGAGGTGAATTTCCGCGTTCCGGGTCAAAGTCTGCGTTTTATTATTATAGGATATCCCAT 
               
               
                   
               
               
                 TGCATACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTT 
               
               
                   
               
               
                 GACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATG 
               
               
                   
               
               
                 GAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCAT 
               
               
                   
               
               
                 TGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGT 
               
               
                   
               
               
                 GGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCT 
               
               
                   
               
               
                 ATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCC 
               
               
                   
               
               
                 TACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCA 
               
               
                   
               
               
                 ATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAG 
               
               
                   
               
               
                 TTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAA 
               
               
                   
               
               
                 TGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCCCTATCAGTGATAGAGATCT 
               
               
                   
               
               
                 CCCTATCAGTGATAGAGATCGTCGACGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT 
               
               
                   
               
               
                 CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGCGGCCGGGAACGGTGCA 
               
               
                   
               
               
                 TTGGAACGCGGATTCCCCGTGCCAAGAGTGAGATCTTCCGTTTATCTAGGTACCGGGCCCCCCCTCGA 
               
               
                   
               
               
                 GGTCGACGGTATCGATAAGCTTCACGCTGCCGCAAGCACTCAGGGCGCAAGGGCTGCTAAAGGAAG 
               
               
                   
               
               
                 CGGAACACGTAGAAAGCCAGTCCGCAGAAACGGTGCTGACCCCGGATGAATGTCAGCTACTGGGCT 
               
               
                   
               
               
                 ATCTGGACAAGGGAAAACGCAAGCGCAAAGAGAAAGCAGGTAGCTTGCAGTGGGCTTACATGGCGA 
               
               
                   
               
               
                 TAGCTAGACTGGGCGGTTTTATGGACAGCAAGCGAACCGGAATTGCCAGCTGGGGCGCCCTCTGGTA 
               
               
                   
               
               
                 AGGTTGGGAAGCCCTGCAAAGTAAACTGGATGGCTTTCTTGCCGCCAAGGATCTGATGGCGCAGGGG 
               
               
                   
               
               
                 ATCAAGATCTAACCAGGAGCTATTTAATGGCAACAGTTAACCAGCTGGTACGCAAACCACGTGCTCG 
               
               
                   
               
               
                 CAAAGTTGCGAAAAGCAACGTGCCTGCGCTGGAAGCATGCCCGCAAAAACGTGGCGTATGTACTCGT 
               
               
                   
               
               
                 GTATATACTACCACTCCTAAAAAACCGAACTCCGCGCTGCGTAAAGTATGCCGTGTTCGTCTGACTAA 
               
               
                   
               
               
                 CGGTTTCGAAGTGACTTCCTACATCGGTGGTGAAGGTCACAACCTGCAGGAGCACTCCGTGATCCTG 
               
               
                   
               
               
                 ATCCGTGGCGGTCGTGTTAAAGACCTCCCGGGTGTTCGTTACCACACCGTACGTGGTGCGCTTGACTG 
               
               
                   
               
               
                 CTCCGGCGTTAAAGACCGTAAGCAGGCTCGTTCCAAGTATGGCGTGAAGCGTCCTAAGGCTTAATGG 
               
               
                   
               
               
                 TAGATCTGATCAAGAGACAGGATGACGGTCGTTTCGCATGCTTGAACAAGATGGATTGCACGCAGGT 
               
               
                   
               
               
                 TCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTG 
               
               
                   
               
               
                 ATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGT 
               
               
                   
               
               
                 GCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCG 
               
               
                   
               
               
                 CAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCA 
               
               
                   
               
               
                 GGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGC 
               
               
                   
               
               
                 TGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACG 
               
               
                   
               
               
                 TACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCA 
               
               
                   
               
               
                 GCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCG 
               
               
                   
               
               
                 ATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTG 
               
               
                   
               
               
                 GGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCG 
               
               
                   
               
               
                 AATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTAT 
               
               
                   
               
               
                 CGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAA 
               
               
                   
               
               
                 CCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCC 
               
               
                   
               
               
                 GGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCGGGCT 
               
               
                   
               
               
                 CGATCCCCTCGGGGGGAATCAGAATTCAGTCGACAGCGGCCGCGATCTGCTGTGCCTTCTAGTTGCC 
               
               
                   
               
               
                 AGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTT 
               
               
                   
               
               
                 CCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGT 
               
               
                   
               
               
                 GGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCT 
               
               
                   
               
               
                 CTATGGCCGATCAGCGATCGCTGAGGTGGGTGAGTGGGCGTGGCCTGGGGTGGTCATGAAAATATAT 
               
               
                   
               
               
                 AAGTTGGGGGTCTTAGGGTCTCTTTATTTGTGTTGCAGAGACCGCCGGAGCCATGAGCGGGAGCAGC 
               
               
                   
               
               
                 AGCAGCAGCAGTAGCAGCAGCGCCTTGGATGGCAGCATCGTGAGCCCTTATTTGACGACGCGGATGC 
               
               
                   
               
               
                 CCCACTGGGCCGGGGTGCGTCAGAATGTGATGGGCTCCAGCATCGACGGCCGACCCGTCCTGCCCGC 
               
               
                   
               
               
                 AAATTCCGCCACGCTGACCTATGCGACCGTCGCGGGGACGCCGTTGGACGCCACCGCCGCCGCCGCC 
               
               
                   
               
               
                 GCCACCGCAGCCGCCTCGGCCGTGCGCAGCCTGGCCACGGACTTTGCATTCCTGGGACCACTGGCGA 
               
               
                   
               
               
                 CAGGGGCTACTTCTCGGGCCGCTGCTGCCGCCGTTCGCGATGACAAGCTGACCGCCCTGCTGGCGCA 
               
               
                   
               
               
                 GTTGGATGCGCTTACTCGGGAACTGGGTGACCTTTCTCAGCAGGTCATGGCCCTGCGCCAGCAGGTCT 
               
               
                   
               
               
                 CCTCCCTGCAAGCTGGCGGGAATGCTTCTCCCACAAATGCCGTTTAAGATAAATAAAACCAGACTCT 
               
               
                   
               
               
                 GTTTGGATTAAAGAAAAGTAGCAAGTGCATTGCTCTCTTTATTTCATAATTTTCCGCGCGCGATAGGC 
               
               
                   
               
               
                 CCTAGACCAGCGTTCTCGGTCGTTGAGGGTGCGGTGTATCTTCTCCAGGACGTGGTAGAGGTGGCTCT 
               
               
                   
               
               
                 GGACGTTGAGATACATGGGCATGAGCCCGTCCCGGGGGTGGAGGTAGCACCACTGCAGAGCTTCATG 
               
               
                   
               
               
                 CTCCGGGGTGGTGTTGTAGATGATCCAGTCGTAGCAGGAGCGCTGGGCATGGTGCCTAAAAATGTCC 
               
               
                   
               
               
                 TTCAGCAGCAGGCCGATGGCCAGGGGGAGGCCCTTGGTGTAAGTGTTTACAAAACGGTTAAGTTGGG 
               
               
                   
               
               
                 AAGGGTGCATTCGGGGAGAGATGATGTGCATCTTGGACTGTATTTTTAGATTGGCGATGTTTCCGCCC 
               
               
                   
               
               
                 AGATCCCTTCTGGGATTCATGTTGTGCAGGACCACCAGTACAGTGTATCCGGTGCACTTGGGGAATTT 
               
               
                   
               
               
                 GTCATGCAGCTTAGAGGGAAAAGCGTGGAAGAACTTGGAGACGCCTTTGTGGCCTCCCAGATTTTCC 
               
               
                   
               
               
                 ATGCATTCGTCCATGATGATGGCAATGGGCCCGCGGGAGGCAGCTTGGGCAAAGATATTTCTGGGGT 
               
               
                   
               
               
                 CGCTGACGTCGTAGTTGTGTTCCAGGGTGAGGTCGTCATAGGCCATTTTTACAAAGCGCGGGCGGAG 
               
               
                   
               
               
                 GGTGCCCGACTGGGGGATGATGGTCCCCTCTGGCCCTGGGGCGTAGTTGCCCTCGCAGATCTGCATTT 
               
               
                   
               
               
                 CCCAGGCCTTAATCTCGGAGGGGGGAATCATATCCACCTGCGGGGCGATGAAGAAAACGGTTTCCGG 
               
               
                   
               
               
                 AGCCGGGGAGATTAACTGGGATGAGAGCAGGTTTCTAAGCAGCTGTGATTTTCCACAACCGGTGGGC 
               
               
                   
               
               
                 CCATAAATAACACCTATAACCGGTTGCAGCTGGTAGTTTAGAGAGCTGCAGCTGCCGTCGTCCCGGA 
               
               
                   
               
               
                 GGAGGGGGGCCACCTCGTTGAGCATGTCCCTGACGCGCATGTTCTCCCCGACCAGATCCGCCAGAAG 
               
               
                   
               
               
                 GCGCTCGCCGCCCAGGGACAGCAGCTCTTGCAAGGAAGCAAAGTTTTTCAGCGGCTTGAGGCCGTCC 
               
               
                   
               
               
                 GCCGTGGGCATGTTTTTCAGGGTCTGGCTCAGCAGCTCCAGGCGGTCCCAGAGCTCGGTGACGTGCT 
               
               
                   
               
               
                 CTACGGCATCTCTATCCAGCATATCTCCTCGTTTCGCGGGTTGGGGCGACTTTCGCTGTAGGGCACCA 
               
               
                   
               
               
                 AGCGGTGGTCGTCCAGCGGGGCCAGAGTCATGTCCTTCCATGGGCGCAGGGTCCTCGTCAGGGTGGT 
               
               
                   
               
               
                 CTGGGTCACGGTGAAGGGGTGCGCTCCGGGCTGAGCGCTTGCCAAGGTGCGCTTGAGGCTGGTTCTG 
               
               
                   
               
               
                 CTGGTGCTGAAGCGCTGCCGGTCTTCGCCCTGCGCGTCGGCCAGGTAGCATTTGACCATGGTGTCATA 
               
               
                   
               
               
                 GTCCAGCCCCTCCGCGGCGTGTCCCTTGGCGCGCAGCTTGCCCTTGGAGGTGGCGCCGCACGAGGGG 
               
               
                   
               
               
                 CAGAGCAGGCTCTTGAGCGCGTAGAGCTTGGGGGCGAGGAAGACCGATTCGGGGGAGTAGGCGTCC 
               
               
                   
               
               
                 GCGCCGCAGACCCCGCACACGGTCTCGCACTCCACCAGCCAGGTGAGCTCGGGGCGCGCCGGGTCAA 
               
               
                   
               
               
                 AAACCAGGTTTCCCCCATGCTTTTTGATGCGTTTCTTACCTCGGGTCTCCATGAGGTGGTGTCCCCGCT 
               
               
                   
               
               
                 CGGTGACGAAGAGGCTGTCCGTGTCTCCGTAGACCGACTTGAGGGGTCTTTTCTCCAGGGGGGTCCC 
               
               
                   
               
               
                 TCGGTCTTCCTCGTAGAGGAACTCGGACCACTCTGAGACGAAGGCCCGCGTCCAGGCCAGGACGAAG 
               
               
                   
               
               
                 GAGGCTATGTGGGAGGGGTAGCGGTCGTTGTCCACTAGGGGGTCCACCTTCTCCAAGGTGTGAAGAC 
               
               
                   
               
               
                 ACATGTCGCCTTCCTCGGCGTCCAGGAAGGTGATTGGCTTGTAGGTGTAGGCCACGTGACCGGGGGT 
               
               
                   
               
               
                 TCCTGACGGGGGGGTATAAAAGGGGGTGGGGGCGCGCTCGTCGTCACTCTCTTCCGCATCGCTGTCT 
               
               
                   
               
               
                 GCGAGGGCCAGCTGCTGGGGTGAGTATTCCCTCTCGAAGGCGGGCATGACCTCCGCGCTGAGGTTGT 
               
               
                   
               
               
                 CAGTTTCCAAAAACGAGGAGGATTTGATGTTCACCTGTCCCGAGGTGATACCTTTGAGGGTACCCGC 
               
               
                   
               
               
                 GTCCATCTGGTCAGAAAACACGATCTTTTTATTGTCCAGCTTGGTGGCGAACGACCCGTAGAGGGCG 
               
               
                   
               
               
                 TTGGAGAGCAGCTTGGCGATGGAGCGCAGGGTCTGGTTCTTGTCCCTGTCGGCGCGCTCCTTGGCCGC 
               
               
                   
               
               
                 GATGTTGAGCTGCACGTACTCGCGCGCGACGCAGCGCCACTCGGGGAAGACGGTGGTGCGCTCGTCG 
               
               
                   
               
               
                 GGCACCAGGCGCACGCGCCAGCCGCGGTTGTGCAGGGTGACCAGGTCCACGCTGGTGGCGACCTCGC 
               
               
                   
               
               
                 CGCGCAGGCGCTCGTTGGTCCAGCAGAGACGGCCGCCCTTGCGCGAGCAGAAGGGGGGCAGGGGGT 
               
               
                   
               
               
                 CGAGCTGGGTCTCGTCCGGGGGGTCCGCGTCCACGGTGAAAACCCCGGGGCGCAGGCGCGCGTCGA 
               
               
                   
               
               
                 AGTAGTCTATCTTGCAACCTTGCATGTCCAGCGCCTGCTGCCAGTCGCGGGCGGCGAGCGCGCGCTC 
               
               
                   
               
               
                 GTAGGGGTTGAGCGGCGGGCCCCAGGGCATGGGGTGGGTGAGTGCGGAGGCGTACATGCCGCAGAT 
               
               
                   
               
               
                 GTCATAGACGTAGAGGGGCTCCCGCAGGACCCCGATGTAGGTGGGGTAGCAGCGGCCGCCGCGGAT 
               
               
                   
               
               
                 GCTGGCGCGCACGTAGTCATACAGCTCGTGCGAGGGGGCGAGGAGGTCGGGGCCCAGGTTGGTGCG 
               
               
                   
               
               
                 GGCGGGGCGCTCCGCGCGGAAGACGATCTGCCTGAAGATGGCATGCGAGTTGGAAGAGATGGTGGG 
               
               
                   
               
               
                 GCGCTGGAAGACGTTGAAGCTGGCGTCCTGCAGGCCGACGGCGTCGCGCACGAAGGAGGCGTAGGA 
               
               
                   
               
               
                 GTCGCGCAGCTTGTGTACCAGCTCGGCGGTGACCTGCACGTCGAGCGCGCAGTAGTCGAGGGTCTCG 
               
               
                   
               
               
                 CGGATGATGTCATATTTAGCCTGCCCCTTCTTTTTCCACAGCTCGCGGTTGAGGACAAACTCTTCGCG 
               
               
                   
               
               
                 GTCTTTCCAGTACTCTTGGATCGGGAAACCGTCCGGTTCCGAACGGTAAGAGCCTAGCATGTAGAAC 
               
               
                   
               
               
                 TGGTTGACGGCCTGGTAGGCGCAGCAGCCCTTCTCCACGGGGAGGGCGTAGGCCTGCGCGGCCTTGC 
               
               
                   
               
               
                 GGAGCGAGGTGTGGGTCAGGGCGAAGGTGTCCCTGACCATGACTTTGAGGTACTGGTGCTTGAAGTC 
               
               
                   
               
               
                 GGAGTCGTCGCAGCCGCCCCGCTCCCAGAGCGAGAAGTCGGTGCGCTTCTTGGAGCGGGGGTTGGGC 
               
               
                   
               
               
                 AGAGCGAAGGTGACATCGTTGAAGAGGATTTTGCCCGCGCGGGGCATGAAGTTGCGGGTGATGCGG 
               
               
                   
               
               
                 AAGGGCCCCGGCACTTCAGAGCGGTTGTTGATGACCTGGGCGGCGAGCACGATCTCGTCGAAGCCGT 
               
               
                   
               
               
                 TGATGTTGTGGCCCACGATGTAGAGTTCCAGGAAGCGGGGCCGGCCCTTTACGGTGGGCAGCTTCTT 
               
               
                   
               
               
                 TAGCTCTTCGTAGGTGAGCTCCTCGGGCGAGGCGAGGCCGTGCTCGGCCAGGGCCCAGTCCGCGAGG 
               
               
                   
               
               
                 TGCGGGTTGTCTCTGAGGAAGGACTTCCAGAGGTCGCGGGCCAGGAGGGTCTGCAGGCGGTCTCTGA 
               
               
                   
               
               
                 AGGTCCTGAACTGGCGGCCCACGGCCATTTTTTCGGGGGTGATGCAGTAGAAGGTGAGGGGGTCTTG 
               
               
                   
               
               
                 CTGCCAGCGGTCCCAGTCGAGCTGCAGGGCGAGGTCGCGCGCGGCGGTGACCAGGCGCTCGTCGCCC 
               
               
                   
               
               
                 CCGAATTTCATGACCAGCATGAAGGGCACGAGCTGCTTTCCGAAGGCCCCCATCCAAGTGTAGGTCT 
               
               
                   
               
               
                 CTACATCGTAGGTGACAAAGAGGCGCTCCGTGCGAGGATGCGAGCCGATCGGGAAGAACTGGATCT 
               
               
                   
               
               
                 CCCGCCACCAGTTGGAGGAGTGGCTGTTGATGTGGTGGAAGTAGAAGTCCCGTCGCCGGGCCGAACA 
               
               
                   
               
               
                 CTCGTGCTGGCTTTTGTAAAAGCGAGCGCAGTACTGGCAGCGCTGCACGGGCTGTACCTCATGCACG 
               
               
                   
               
               
                 AGATGCACCTTTCGCCCGCGCACGAGGAAGCCGAGGGGAAATCTGAGCCCCCCGCCTGGCTCGCGGC 
               
               
                   
               
               
                 ATGGCTGGTTCTCTTCTACTTTGGATGCGTGTCCGTCTCCGTCTGGCTCCTCGAGGGGTGTTACGGTG 
               
               
                   
               
               
                 GAGCGGACCACCACGCCGCGCGAGCCGCAGGTCCAGATATCGGCGCGCGGCGGTCGGAGTTTGATG 
               
               
                   
               
               
                 ACGACATCGCGCAGCTGGGAGCTGTCCATGGTCTGGAGCTCCCGCGGCGGCGGCAGGTCAGCCGGG 
               
               
                   
               
               
                 AGTTCTTGCAGGTTCACCTCGCAGAGTCGGGCCAGGGCGCGGGGCAGGTCTAGGTGGTACCTGATCT 
               
               
                   
               
               
                 CTAGGGGCGTGTTGGTGGCGGCGTCGATGGCTTGCAGGAGCCCGCAGCCCCGGGGGGCGACGACGG 
               
               
                   
               
               
                 TGCCCCGCGGGGTGGTGGTGGTGGTGGCGGTGCAGCTCAGAAGCGGTGCCGCGGGCGGGCCCCCGG 
               
               
                   
               
               
                 AGGTAGGGGGGGCTCCGGTCCCGCGGGCAGGGGCGGCAGCGGCACGTCGGCGTGGAGCGCGGGCAG 
               
               
                   
               
               
                 GAGTTGGTGCTGTGCCCGGAGGTTGCTGGCGAAGGCGACGACGCGGCGGTTGATCTCCTGGATCTGG 
               
               
                   
               
               
                 CGCCTCTGCGTGAAGACGACGGGCCCGGTGAGCTTGAACCTGAAAGAGAGTTCGACAGAATCAATCT 
               
               
                   
               
               
                 CGGTGTCATTGACCGCGGCCTGGCGCAGGATCTCCTGCACGTCTCCCGAGTTGTCTTGGTAGGCGATC 
               
               
                   
               
               
                 TCGGCCATGAACTGCTCGATCTCTTCCTCCTGGAGGTCTCCGCGTCCGGCGCGTTCCACGGTGGCCGC 
               
               
                   
               
               
                 CAGGTCGTTGGAGATGCGCCCCATGAGCTGCGAGAAGGCGTTGAGTCCGCCCTCGTTCCAGACTCGG 
               
               
                   
               
               
                 CTGTAGACCACGCCCCCCTGGTCATCGCGGGCGCGCATGACCACCTGCGCGAGGTTGAGCTCCACGT 
               
               
                   
               
               
                 GCCGCGCGAAGACGGCGTAGTTGCGCAGACGCTGGAAGAGGTAGTTGAGGGTGGTGGCGGTGTGCT 
               
               
                   
               
               
                 CGGCCACGAAGAAGTTCATGACCCAGCGGCGCAACGTGGATTCGTTGATGTCCCCCAAGGCCTCCAG 
               
               
                   
               
               
                 CCGTTCCATGGCCTCGTAGAAGTCCACGGCGAAGTTGAAAAACTGGGAGTTGCGCGCCGACACGGTC 
               
               
                   
               
               
                 AACTCCTCCTCCAGAAGACGGATGAGCTCGGCGACGGTGTCGCGCACCTCGCGCTCGAAGGCTATGG 
               
               
                   
               
               
                 GGATCTCTTCCTCCGCTAGCATCACCACCTCCTCCTCTTCCTCCTCTTCTGGCACTTCCATGATGGCTT 
               
               
                   
               
               
                 CCTCCTCTTCGGGGGGTGGCGGCGGCGGCGGTGGGGGAGGGGGCGCTCTGCGCCGGCGGCGGCGCA 
               
               
                   
               
               
                 CCGGGAGGCGGTCCACGAAGCGCGCGATCATCTCCCCGCGGCGGCGGCGCATGGTCTCGGTGACGGC 
               
               
                   
               
               
                 GCGGCCGTTCTCCCGGGGGCGCAGTTGGAAGACGCCGCCGGACATCTGGTGCTGGGGCGGGTGGCCG 
               
               
                   
               
               
                 TGAGGCAGCGAGACGGCGCTGACGATGCATCTCAACAATTGCTGCGTAGGTACGCCGCCGAGGGAC 
               
               
                   
               
               
                 CTGAGGGAGTCCATATCCACCGGATCCGAAAACCTTTCGAGGAAGGCGTCTAACCAGTCGCAGTCGC 
               
               
                   
               
               
                 AAGGTAGGCTGAGCACCGTGGCGGGCGGCGGGGGGTGGGGGGAGTGTCTGGCGGAGGTGCTGCTGA 
               
               
                   
               
               
                 TGATGTAATTGAAGTAGGCGGACTTGACACGGCGGATGGTCGACAGGAGCACCATGTCCTTGGGTCC 
               
               
                   
               
               
                 GGCCTGCTGGATGCGGAGGCGGTCGGCTATGCCCCAGGCTTCGTTCTGGCATCGGCGCAGGTCCTTG 
               
               
                   
               
               
                 TAGTAGTCTTGCATGAGCCTTTCCACCGGCACCTCTTCTCCTTCCTCTTCTGCTTCTTCCATGTCTGCTT 
               
               
                   
               
               
                 CGGCCCTGGGGCGGCGCCGCGCCCCCCTGCCCCCCATGCGCGTGACCCCGAACCCCCTGAGCGGTTG 
               
               
                   
               
               
                 GAGCAGGGCCAGGTCGGCGACGACGCGCTCGGCCAGGATGGCCTGCTGCACCTGCGTGAGGGTGGT 
               
               
                   
               
               
                 TTGGAAGTCATCCAAGTCCACGAAGCGGTGGTAGGCGCCCGTGTTGATGGTGTAGGTGCAGTTGGCC 
               
               
                   
               
               
                 ATGACGGACCAGTTGACGGTCTGGTGGCCCGGTTGCGACATCTCGGTGTACCTGAGTCGCGAGTAGG 
               
               
                   
               
               
                 CGCGGGAGTCGAAGACGTAGTCGTTGCAAGTCCGCACCAGGTACTGGTAGCCCACCAGGAAGTGCG 
               
               
                   
               
               
                 GCGGCGGCTGGCGGTAGAGGGGCCAGCGCAGGGTGGCGGGGGCTCCGGGGGCCAGGTCTTCCAGCA 
               
               
                   
               
               
                 TGAGGCGGTGGTAGGCGTAGATGTACCTGGACATCCAGGTGATACCCGCGGCGGTGGTGGAGGCGC 
               
               
                   
               
               
                 GCGGGAAGTCGCGCACCCGGTTCCAGATGTTGCGCAGGGGCAGAAAGTGCTCCATGGTAGGCGTGCT 
               
               
                   
               
               
                 CTGTCCAGTCAGACGCGCGCAGTCGTTGATACTCTAGACCAGGGAAAACGAAAGCCGGTCAGCGGG 
               
               
                   
               
               
                 CACTCTTCCGTGGTCTGGTGAATAGATCGCAAGGGTATCATGGCGGAGGGCCTCGGTTCGAGCCCCG 
               
               
                   
               
               
                 GGTCCGGGCCGGACGGTCCGCCATGATCCACGCGGTTACCGCCCGCGTGTCGAACCCAGGTGTGCGA 
               
               
                   
               
               
                 CGTCAGACAACGGTGGAGTGTTCCTTTTGGCGTTTTTCTGGCCGGGCGCCGGCGCCGCGTAAGAGAC 
               
               
                   
               
               
                 TAAGCCGCGAAAGCGAAAGCAGTAAGTGGCTCGCTCCCCGTAGCCGGAGGGATCCTTGCTAAGGGTT 
               
               
                   
               
               
                 GCGTTGCGGCGAACCCCGGTTCGAATCCCGTACTCGGGCCGGCCGGACCCGCGGCTAAGGTGTTGGA 
               
               
                   
               
               
                 TTGGCCTCCCCCTCGTATAAAGACCCCGCTTGCGGATTGACTCCGGACACGGGGACGAGCCCCTTTTA 
               
               
                   
               
               
                 TTTTTGCTTTCCCCAGATGCATCCGGTGCTGCGGCAGATGCGCCCCCCGCCCCAGCAGCAGCAACAAC 
               
               
                   
               
               
                 ACCAGCAAGAGCGGCAGCAACAGCAGCGGGAGTCATGCAGGGCCCCCTCACCCACCCTCGGCGGGC 
               
               
                   
               
               
                 CGGCCACCTCGGCGTCCGCGGCCGTGTCTGGCGCCTGCGGCGGCGGCGGGGGGCCGGCTGACGACCC 
               
               
                   
               
               
                 CGAGGAGCCCCCGCGGCGCAGGGCCAGACACTACCTGGACCTGGAGGAGGGCGAGGGCCTGGCGCG 
               
               
                   
               
               
                 GCTGGGGGCGCCGTCTCCCGAGCGCCACCCGCGGGTGCAGCTGAAGCGCGACTCGCGCGAGGCGTA 
               
               
                   
               
               
                 CGTGCCTCGGCAGAACCTGTTCAGGGACCGCGCGGGCGAGGAGCCCGAGGAGATGCGGGACAGGAG 
               
               
                   
               
               
                 GTTCAGCGCAGGGCGGGAGCTGCGGCAGGGGCTGAACCGCGAGCGGCTGCTGCGCGAGGAGGACTT 
               
               
                   
               
               
                 TGAGCCCGACGCGCGGACGGGGATCAGCCCCGCGCGCGCGCACGTGGCGGCCGCCGACCTGGTGAC 
               
               
                   
               
               
                 GGCGTACGAGCAGACGGTGAACCAGGAGATCAACTTCCAAAAGAGTTTCAACAACCACGTGCGCAC 
               
               
                   
               
               
                 GCTGGTGGCGCGCGAGGAGGTGACCATCGGGCTGATGCACCTGTGGGACTTTGTAAGCGCGCTGGTG 
               
               
                   
               
               
                 CAGAACCCCAACAGCAAGCCTCTGACGGCGCAGCTGTTCCTGATAGTGCAGCACAGCAGGGACAAC 
               
               
                   
               
               
                 GAGGCGTTTAGGGACGCGCTGCTGAACATCACCGAGCCCGAGGGTCGGTGGCTGCTGGACCTGATTA 
               
               
                   
               
               
                 ACATCCTGCAGAGCATAGTGGTGCAGGAGCGCAGCCTGAGCCTGGCCGACAAGGTGGCGGCCATCA 
               
               
                   
               
               
                 ACTACTCGATGCTGAGCCTGGGCAAGTTTTACGCGCGCAAGATCTACCAGACGCCGTACGTGCCCAT 
               
               
                   
               
               
                 AGACAAGGAGGTGAAGATCGACGGTTTTTACATGCGCATGGCGCTGAAGGTGCTCACCCTGAGCGAC 
               
               
                   
               
               
                 GACCTGGGCGTGTACCGCAACGAGCGCATCCACAAGGCCGTGAGCGTGAGCCGGCGGCGCGAGCTG 
               
               
                   
               
               
                 AGCGACCGCGAGCTGATGCACAGCCTGCAGCGGGCGCTGGCGGGCGCCGGCAGCGGCGACAGGGAG 
               
               
                   
               
               
                 GCGGAGTCCTACTTCGATGCGGGGGCGGACCTGCGCTGGGCGCCCAGCCGGCGGGCCCTGGAGGCC 
               
               
                   
               
               
                 GCGGGGGTCCGCGAGGACTATGACGAGGACGGCGAGGAGGATGAGGAGTACGAGCTAGAGGAGGG 
               
               
                   
               
               
                 CGAGTACCTGGACTAAACCGCGGGTGGTGTTTCCGGTAGATGCAAGACCCGAACGTGGTGGACCCGG 
               
               
                   
               
               
                 CGCTGCGGGCGGCTCTGCAGAGCCAGCCGTCCGGCCTTAACTCCTCAGACGACTGGCGACAGGTCAT 
               
               
                   
               
               
                 GGACCGCATCATGTCGCTGACGGCGCGTAACCCGGACGCGTTCCGGCAGCAGCCGCAGGCCAACAG 
               
               
                   
               
               
                 GCTCTCCGCCATCCTGGAGGCGGTGGTGCCTGCGCGCTCGAACCCCACGCACGAGAAGGTGCTGGCC 
               
               
                   
               
               
                 ATAGTGAACGCGCTGGCCGAGAACAGGGCCATCCGCCCGGACGAGGCCGGGCTGGTGTACGACGCG 
               
               
                   
               
               
                 CTGCTGCAGCGCGTGGCCCGCTACAACAGCGGCAACGTGCAGACCAACCTGGACCGGCTGGTGGGG 
               
               
                   
               
               
                 GACGTGCGCGAGGCGGTGGCGCAGCGCGAGCGCGCGGATCGGCAGGGCAACCTGGGCTCCATGGTG 
               
               
                   
               
               
                 GCGCTGAATGCCTTCCTGAGCACGCAGCCGGCCAACGTGCCGCGGGGGCAGGAAGACTACACCAAC 
               
               
                   
               
               
                 TTTGTGAGCGCGCTGCGGCTGATGGTGACCGAGACCCCCCAGAGCGAGGTGTACCAGTCGGGCCCGG 
               
               
                   
               
               
                 ACTACTTCTTCCAGACCAGCAGACAGGGCCTGCAGACGGTGAACCTGAGCCAGGCTTTCAAGAACCT 
               
               
                   
               
               
                 GCGGGGGCTGTGGGGCGTGAAGGCGCCCACCGGCGACCGGGCGACGGTGTCCAGCCTGCTGACGCC 
               
               
                   
               
               
                 CAACTCGCGCCTGCTGCTGCTGCTGATCGCGCCGTTCACGGACAGCGGCAGCGTGTCCCGGGACACC 
               
               
                   
               
               
                 TACCTGGGGCACCTGCTGACCCTGTACCGCGAGGCCATCGGGCAGGCGCAGGTGGACGAGCACACCT 
               
               
                   
               
               
                 TCCAGGAGATCACCAGCGTGAGCCGCGCGCTGGGGCAGGAGGACACGAGCAGCCTGGAGGCGACTC 
               
               
                   
               
               
                 TGAACTACCTGCTGACCAACCGGCGGCAGAAGATTCCCTCGCTGCACAGCCTGACCTCCGAGGAGGA 
               
               
                   
               
               
                 GCGCATCTTGCGCTACGTGCAGCAGAGCGTGAGCCTGAACCTGATGCGCGACGGGGTGACGCCCAGC 
               
               
                   
               
               
                 GTGGCGCTGGACATGACCGCGCGCAACATGGAACCGGGCATGTACGCCGCGCACCGGCCTTACATCA 
               
               
                   
               
               
                 ACCGCCTGATGGACTACCTGCATCGCGCGGCGGCCGTGAACCCCGAGTACTTTACCAACGCCATCCT 
               
               
                   
               
               
                 GAACCCGCACTGGCTCCCGCCGCCCGGGTTCTACAGCGGGGGCTTCGAGGTCCCGGAGACCAACGAT 
               
               
                   
               
               
                 GGCTTCCTGTGGGACGACATGGACGACAGCGTGTTCTCCCCGCGGCCGCAGGCGCTGGCGGAAGCGT 
               
               
                   
               
               
                 CCCTGCTGCGTCCCAAGAAGGAGGAGGAGGAGGAGGCGAGTCGCCGCCGCGGCAGCAGCGGCGTGG 
               
               
                   
               
               
                 CTTCTCTGTCCGAGCTGGGGGCGGCAGCCGCCGCGCGCCCCGGGTCCCTGGGCGGCAGCCCCTTTCC 
               
               
                   
               
               
                 GAGCCTGGTGGGGTCTCTGCACAGCGAGCGCACCACCCGCCCTCGGCTGCTGGGCGAGGACGAGTAC 
               
               
                   
               
               
                 CTGAATAACTCCCTGCTGCAGCCGGTGCGGGAGAAAAACCTGCCTCCCGCCTTCCCCAACAACGGGA 
               
               
                   
               
               
                 TAGAGAGCCTGGTGGACAAGATGAGCAGATGGAAGACCTATGCGCAGGAGCACAGGGACGCGCCTG 
               
               
                   
               
               
                 CGCTCCGGCCGCCCACGCGGCGCCAGCGCCACGACCGGCAGCGGGGGCTGGTGTGGGATGACGAGG 
               
               
                   
               
               
                 ACTCCGCGGACGATAGCAGCGTGCTGGACCTGGGAGGGAGCGGCAACCCGTTCGCGCACCTGCGCCC 
               
               
                   
               
               
                 CCGCCTGGGGAGGATGTTTTAAAAAAAAAAAAAAAAAGCAAGAAGCATGATGCAAAAATTAAATAA 
               
               
                   
               
               
                 AACTCACCAAGGCCATGGCGACCGAGCGTTGGTTTCTTGTGTTCCCTTCAGTATGCGGCGCGCGGCG 
               
               
                   
               
               
                 ATGTACCAGGAGGGACCTCCTCCCTCTTACGAGAGCGTGGTGGGCGCGGCGGCGGCGGCGCCCTCTT 
               
               
                   
               
               
                 CTCCCTTTGCGTCGCAGCTGCTGGAGCCGCCGTACGTGCCTCCGCGCTACCTGCGGCCTACGGGGGG 
               
               
                   
               
               
                 GAGAAACAGCATCCGTTACTCGGAGCTGGCGCCCCTGTTCGACACCACCCGGGTGTACCTGGTGGAC 
               
               
                   
               
               
                 AACAAGTCGGCGGACGTGGCCTCCCTGAACTACCAGAACGACCACAGCAATTTTTTGACCACGGTCA 
               
               
                   
               
               
                 TCCAGAACAATGACTACAGCCCGAGCGAGGCCAGCACCCAGACCATCAATCTGGATGACCGGTCGC 
               
               
                   
               
               
                 ACTGGGGCGGCGACCTGAAAACCATCCTGCACACCAACATGCCCAACGTGAACGAGTTCATGTTCAC 
               
               
                   
               
               
                 CAATAAGTTCAAGGCGCGGGTGATGGTGTCGCGCTCGCACACCAAGGAAGACCGGGTGGAGCTGAA 
               
               
                   
               
               
                 GTACGAGTGGGTGGAGTTCGAGCTGCCAGAGGGCAACTACTCCGAGACCATGACCATTGACCTGATG 
               
               
                   
               
               
                 AACAACGCGATCGTGGAGCACTATCTGAAAGTGGGCAGGCAGAACGGGGTCCTGGAGAGCGACATC 
               
               
                   
               
               
                 GGGGTCAAGTTCGACACCAGGAACTTCCGCCTGGGGCTGGACCCCGTGACCGGGCTGGTTATGCCCG 
               
               
                   
               
               
                 GGGTGTACACCAACGAGGCCTTCCATCCCGACATCATCCTGCTGCCCGGCTGCGGGGTGGACTTCAC 
               
               
                   
               
               
                 TTACAGCCGCCTGAGCAACCTCCTGGGCATCCGCAAGCGGCAGCCCTTCCAGGAGGGCTTCAGGATC 
               
               
                   
               
               
                 ACCTACGAGGACCTGGAGGGGGGCAACATCCCCGCGCTCCTCGATGTGGAGGCCTACCAGGATAGCT 
               
               
                   
               
               
                 TGAAGGAAAATGAGGCGGGACAGGAGGATACCGCCCCCGCCGCCTCCGCCGCCGCCGAGCAGGGCG 
               
               
                   
               
               
                 AGGATGCTGCTGACACCGCGGCCGCGGACGGGGCAGAGGCCGACCCCGCTATGGTGGTGGAGGCTC 
               
               
                   
               
               
                 CCGAGCAGGAGGAGGACATGAATGACAGTGCGGTGCGCGGAGACACCTTCGTCACCCGGGGGGAGG 
               
               
                   
               
               
                 AAAAGCAAGCGGAGGCCGAGGCCGCGGCCGAGGAAAAGCAACTGGCGGCAGCAGCGGCGGCGGCG 
               
               
                   
               
               
                 GCGTTGGCCGCGGCGGAGGCTGAGTCTGAGGGGACCAAGCCCGCCAAGGAGCCCGTGATTAAGCCC 
               
               
                   
               
               
                 CTGACCGAAGATAGCAAGAAGCGCAGTTACAACCTGCTCAAGGACAGCACCAACACCGCGTACCGC 
               
               
                   
               
               
                 AGCTGGTACCTGGCCTACAACTACGGCGACCCGTCGACGGGGGTGCGCTCCTGGACCCTGCTGTGCA 
               
               
                   
               
               
                 CGCCGGACGTGACCTGCGGCTCGGAGCAGGTGTACTGGTCGCTGCCCGACATGATGCAAGACCCCGT 
               
               
                   
               
               
                 GACCTTCCGCTCCACGCGGCAGGTCAGCAACTTCCCGGTGGTGGGCGCCGAGCTGCTGCCCGTGCAC 
               
               
                   
               
               
                 TCCAAGAGCTTCTACAACGACCAGGCCGTCTACTCCCAGCTCATCCGCCAGTTCACCTCTCTGACCCA 
               
               
                   
               
               
                 CGTGTTCAATCGCTTTCCTGAGAACCAGATTCTGGCGCGCCCGCCCGCCCCCACCATCACCACCGTCA 
               
               
                   
               
               
                 GTGAAAACGTTCCTGCTCTCACAGATCACGGGACGCTACCGCTGCGCAACAGCATCGGAGGAGTCCA 
               
               
                   
               
               
                 GCGAGTGACCGTTACTGACGCCAGACGCCGCACCTGCCCCTACGTTTACAAGGCCTTGGGCATAGTC 
               
               
                   
               
               
                 TCGCCGCGCGTCCTTTCCAGCCGCACTTTTTGAGCAACACCACCATCATGTCCATCCTGATCTCACCC 
               
               
                   
               
               
                 AGCAATAACTCCGGCTGGGGACTGCTGCGCGCGCCCAGCAAGATGTTCGGAGGGGCGAGGAAGCGT 
               
               
                   
               
               
                 TCCGAGCAGCACCCCGTGCGCGTGCGCGGGCACTTCCGCGCCCCCTGGGGAGCGCACAAACGCGGCC 
               
               
                   
               
               
                 GCGCGGGGCGCACCACCGTGGACGACGCCATCGACTCGGTGGTGGAGCAGGCGCGCAACTACAGGC 
               
               
                   
               
               
                 CCGCGGTCTCTACCGTGGACGCGGCCATCCAGACCGTGGTGCGGGGCGCGCGGCGGTACGCCAAGCT 
               
               
                   
               
               
                 GAAGAGCCGCCGGAAGCGCGTGGCCCGCCGCCACCGCCGCCGACCCGGGGCCGCCGCCAAACGCGC 
               
               
                   
               
               
                 CGCCGCGGCCCTGCTTCGCCGGGCCAAGCGCACGGGCCGCCGCGCCGCCATGAGGGCCGCGCGCCGC 
               
               
                   
               
               
                 TTGGCCGCCGGCATCACCGCCGCCACCATGGCCCCCCGTACCCGAAGACGCGCGGCCGCCGCCGCCG 
               
               
                   
               
               
                 CCGCCGCCATCAGTGACATGGCCAGCAGGCGCCGGGGCAACGTGTACTGGGTGCGCGACTCGGTGAC 
               
               
                   
               
               
                 CGGCACGCGCGTGCCCGTGCGCTTCCGCCCCCCGCGGACTTGAGATGATGTGAAAAAACAACACTGA 
               
               
                   
               
               
                 GTCTCCTGCTGTTGTGTGTATCCCAGCGGCGGCGGCGCGCGCAGCGTCATGTCCAAGCGCAAAATCA 
               
               
                   
               
               
                 AAGAAGAGATGCTCCAGGTCGTCGCGCCGGAGATCTATGGGCCCCCGAAGAAGGAAGAGCAGGATT 
               
               
                   
               
               
                 CGAAGCCCCGCAAGATAAAGCGGGTCAAAAAGAAAAAGAAAGATGATGACGATGCCGATGGGGAG 
               
               
                   
               
               
                 GTGGAGTTCCTGCGCGCCACGGCGCCCAGGCGCCCGGTGCAGTGGAAGGGCCGGCGCGTAAAGCGC 
               
               
                   
               
               
                 GTCCTGCGCCCCGGCACCGCGGTGGTCTTCACGCCCGGCGAGCGCTCCACCCGGACTTTCAAGCGCG 
               
               
                   
               
               
                 TCTATGACGAGGTGTACGGCGACGAAGACCTGCTGGAGCAGGCCAACGAGCGCTTCGGAGAGTTTGC 
               
               
                   
               
               
                 TTACGGGAAGCGTCAGCGGGCGCTGGGGAAGGAGGACCTGCTGGCGCTGCCGCTGGACCAGGGCAA 
               
               
                   
               
               
                 CCCCACCCCCAGTCTGAAGCCCGTGACCCTGCAGCAGGTGCTGCCGAGCAGCGCACCCTCCGAGGCG 
               
               
                   
               
               
                 AAGCGGGGTCTGAAGCGCGAGGGCGGCGACCTGGCGCCCACCGTGCAGCTCATGGTGCCCAAGCGG 
               
               
                   
               
               
                 CAGAGGCTGGAGGATGTGCTGGAGAAAATGAAAGTAGACCCCGGTCTGCAGCCGGACATCAGGGTC 
               
               
                   
               
               
                 CGCCCCATCAAGCAGGTGGCGCCGGGCCTCGGCGTGCAGACCGTGGACGTGGTCATCCCCACCGGCA 
               
               
                   
               
               
                 ACTCCCCCGCCGCCGCCACCACTACCGCTGCCTCCACGGACATGGAGACACAGACCGATCCCGCCGC 
               
               
                   
               
               
                 AGCCGCAGCCGCAGCCGCCGCCGCGACCTCCTCGGCGGAGGTGCAGACGGACCCCTGGCTGCCGCCG 
               
               
                   
               
               
                 GCGATGTCAGCTCCCCGCGCGCGTCGCGGGCGCAGGAAGTACGGCGCCGCCAACGCGCTCCTGCCCG 
               
               
                   
               
               
                 AGTACGCCTTGCATCCTTCCATCGCGCCCACCCCCGGCTACCGAGGCTATACCTACCGCCCGCGAAG 
               
               
                   
               
               
                 AGCCAAGGGTTCCACCCGCCGTCCCCGCCGACGCGCCGCCGCCACCACCCGCCGCCGCCGCCGCAGA 
               
               
                   
               
               
                 CGCCAGCCCGCACTGGCTCCAGTCTCCGTGAGGAAAGTGGCGCGCGACGGACACACCCTGGTGCTGC 
               
               
                   
               
               
                 CCAGGGCGCGCTACCACCCCAGCATCGTTTAAAAGCCTGTTGTGGTTCTTGCAGATATGGCCCTCACT 
               
               
                   
               
               
                 TGCCGCCTCCGTTTCCCGGTGCCGGGATACCGAGGAGGAAGATCGCGCCGCAGGAGGGGTCTGGCCG 
               
               
                   
               
               
                 GCCGCGGCCTGAGCGGAGGCAGCCGCCGCGCGCACCGGCGGCGACGCGCCACCAGCCGACGCATGC 
               
               
                   
               
               
                 GCGGCGGGGTGCTGCCCCTGTTAATCCCCCTGATCGCCGCGGCGATCGGCGCCGTGCCCGGGATCGC 
               
               
                   
               
               
                 CTCCGTGGCCTTGCAAGCGTCCCAGAGGCATTGACAGACTTGCAAACTTGCAAATATGGAAAAAAAA 
               
               
                   
               
               
                 ACCCCAATAAAAAAGTCTAGACTCTCACGCTCGCTTGGTCCTGTGACTATTTTGTAGAATGGAAGAC 
               
               
                   
               
               
                 ATCAACTTTGCGTCGCTGGCCCCGCGTCACGGCTCGCGCCCGTTCCTGGGACACTGGAACGATATCG 
               
               
                   
               
               
                 GCACCAGCAACATGAGCGGTGGCGCCTTCAGTTGGGGCTCTCTGTGGAGCGGCATTAAAAGTATCGG 
               
               
                   
               
               
                 GTCTGCCGTTAAAAATTACGGCTCCCGGGCCTGGAACAGCAGCACGGGCCAGATGTTGAGAGACAA 
               
               
                   
               
               
                 GTTGAAAGAGCAGAACTTCCAGCAGAAGGTGGTGGAGGGCCTGGCCTCCGGCATCAACGGGGTGGT 
               
               
                   
               
               
                 GGACCTGGCCAACCAGGCCGTGCAGAATAAGATCAACAGCAGACTGGACCCCCGGCCGCCGGTGGA 
               
               
                   
               
               
                 GGAGGTGCCGCCGGCGCTGGAGACGGTGTCCCCCGATGGGCGTGGCGAGAAGCGCCCGCGGCCCGA 
               
               
                   
               
               
                 TAGGGAAGAGACCACTCTGGTCACGCAGACCGATGAGCCGCCCCCGTATGAGGAGGCCCTGAAGCA 
               
               
                   
               
               
                 AGGTCTGCCCACCACGCGGCCCATCGCGCCCATGGCCACCGGGGTGGTGGGCCGCCACACCCCCGCC 
               
               
                   
               
               
                 ACGCTGGACTTGCCTCCGCCCGCCGATGTGCCGCAGCAGCAGAAGGCGGCACAGCCGGGCCCGCCCG 
               
               
                   
               
               
                 CGACCGCCTCCCGTTCCTCCGCCGGTCCTCTGCGCCGCGCGGCCAGCGGCCCCCGCGGGGGGGTCGC 
               
               
                   
               
               
                 GAGGCACGGCAACTGGCAGAGCACGCTGAACAGCATCGTGGGTCTGGGGGTGCGGTCCGTGAAGCG 
               
               
                   
               
               
                 CCGCCGATGCTACTGAATAGCTTAGCTAACGTGTTGTATGTGTGTATGCGCCCTATGTCGCCGCCAGA 
               
               
                   
               
               
                 GGAGCTGCTGAGTCGCCGCCGTTCGCGCGCCCACCACCACCGCCACTCCGCCCCTCAAGATGGCGAC 
               
               
                   
               
               
                 CCCATCGATGATGCCGCAGTGGTCGTACATGCACATCTCGGGCCAGGACGCCTCGGAGTACCTGAGC 
               
               
                   
               
               
                 CCCGGGCTGGTGCAGTTCGCCCGCGCCACCGAGAGCTACTTCAGCCTGAGTAACAAGTTTAGGAACC 
               
               
                   
               
               
                 CCACGGTGGCGCCCACGCACGATGTGACCACCGACCGGTCTCAGCGCCTGACGCTGCGGTTCATTCC 
               
               
                   
               
               
                 CGTGGACCGCGAGGACACCGCGTACTCGTACAAGGCGCGGTTCACCCTGGCCGTGGGCGACAACCGC 
               
               
                   
               
               
                 GTGCTGGACATGGCCTCCACCTACTTTGACATCCGCGGGGTGCTGGACCGGGGTCCCACTTTCAAGCC 
               
               
                   
               
               
                 CTACTCTGGCACCGCCTACAACTCCCTGGCCCCCAAGGGCGCTCCCAACTCCTGCGAGTGGGAGCAA 
               
               
                   
               
               
                 GAGGAAACTCAGGCAGTTGAAGAAGCAGCAGAAGAGGAAGAAGAAGATGCTGACGGTCAAGCTGA 
               
               
                   
               
               
                 GGAAGAGCAAGCAGCTACCAAAAAGACTCATGTATATGCTCAGGCTCCCCTTTCTGGCGAAAAAATT 
               
               
                   
               
               
                 AGTAAAGATGGTCTGCAAATAGGAACGGACGCTACAGCTACAGAACAAAAACCTATTTATGCAGAC 
               
               
                   
               
               
                 CCTACATTCCAGCCCGAACCCCAAATCGGGGAGTCCCAGTGGAATGAGGCAGATGCTACAGTCGCCG 
               
               
                   
               
               
                 GCGGTAGAGTGCTAAAGAAATCTACTCCCATGAAACCATGCTATGGTTCCTATGCAAGACCCACAAA 
               
               
                   
               
               
                 TGCTAATGGAGGTCAGGGTGTACTAACGGCAAATGCCCAGGGACAGCTAGAATCTCAGGTTGAAATG 
               
               
                   
               
               
                 CAATTCTTTTCAACTTCTGAAAACGCCCGTAACGAGGCTAACAACATTCAGCCCAAATTGGTGCTGTA 
               
               
                   
               
               
                 TAGTGAGGATGTGCACATGGAGACCCCGGATACGCACCTTTCTTACAAGCCCGCAAAAAGCGATGAC 
               
               
                   
               
               
                 AATTCAAAAATCATGCTGGGTCAGCAGTCCATGCCCAACAGACCTAATTACATCGGCTTCAGAGACA 
               
               
                   
               
               
                 ACTTTATCGGCCTCATGTATTACAATAGCACTGGCAACATGGGAGTGCTTGCAGGTCAGGCCTCTCAG 
               
               
                   
               
               
                 TTGAATGCAGTGGTGGACTTGCAAGACAGAAACACAGAACTGTCCTACCAGCTCTTGCTTGATTCCA 
               
               
                   
               
               
                 TGGGTGACAGAACCAGATACTTTTCCATGTGGAATCAGGCAGTGGACAGTTATGACCCAGATGTTAG 
               
               
                   
               
               
                 AATTATTGAAAATCATGGAACTGAAGACGAGCTCCCCAACTATTGTTTCCCTCTGGGTGGCATAGGG 
               
               
                   
               
               
                 GTAACTGACACTTACCAGGCTGTTAAAACCAACAATGGCAATAACGGGGGCCAGGTGACTTGGACA 
               
               
                   
               
               
                 AAAGATGAAACTTTTGCAGATCGCAATGAAATAGGGGTGGGAAACAATTTCGCTATGGAGATCAACC 
               
               
                   
               
               
                 TCAGTGCCAACCTGTGGAGAAACTTCCTGTACTCCAACGTGGCGCTGTACCTACCAGACAAGCTTAA 
               
               
                   
               
               
                 GTACAACCCCTCCAATGTGGACATCTCTGACAACCCCAACACCTACGATTACATGAACAAGCGAGTG 
               
               
                   
               
               
                 GTGGCCCCGGGGCTGGTGGACTGCTACATCAACCTGGGCGCGCGCTGGTCGCTGGACTACATGGACA 
               
               
                   
               
               
                 ACGTCAACCCCTTCAACCACCACCGCAATGCGGGCCTGCGCTACCGCTCCATGCTCCTGGGCAACGG 
               
               
                   
               
               
                 GCGCTACGTGCCCTTCCACATCCAGGTGCCCCAGAAGTTCTTTGCCATCAAGAACCTCCTCCTCCTGC 
               
               
                   
               
               
                 CGGGCTCCTACACCTACGAGTGGAACTTCAGGAAGGATGTCAACATGGTCCTCCAGAGCTCTCTGGG 
               
               
                   
               
               
                 TAACGATCTCAGGGTGGACGGGGCCAGCATCAAGTTCGAGAGCATCTGCCTCTACGCCACCTTCTTC 
               
               
                   
               
               
                 CCCATGGCCCACAACACGGCCTCCACGCTCGAGGCCATGCTCAGGAACGACACCAACGACCAGTCCT 
               
               
                   
               
               
                 TCAATGACTACCTCTCCGCCGCCAACATGCTCTACCCCATACCCGCCAACGCCACCAACGTCCCCATC 
               
               
                   
               
               
                 TCCATCCCCTCGCGCAACTGGGCGGCCTTCCGCGGCTGGGCCTTCACCCGCCTCAAGACCAAGGAGA 
               
               
                   
               
               
                 CCCCCTCCCTGGGCTCGGGATTCGACCCCTACTACACCTACTCGGGCTCCATTCCCTACCTGGACGGC 
               
               
                   
               
               
                 ACCTTCTACCTCAACCACACTTTCAAGAAGGTCTCGGTCACCTTCGACTCCTCGGTCAGCTGGCCGGG 
               
               
                   
               
               
                 CAACGACCGTCTGCTCACCCCCAACGAGTTCGAGATCAAGCGCTCGGTCGACGGGGAGGGCTACAAC 
               
               
                   
               
               
                 GTGGCCCAGTGCAACATGACCAAGGACTGGTTCCTGGTCCAGATGCTGGCCAACTACAACATCGGCT 
               
               
                   
               
               
                 ACCAGGGCTTCTACATCCCAGAGAGCTACAAGGACAGGATGTACTCCTTCTTCAGGAACTTCCAGCC 
               
               
                   
               
               
                 CATGAGCCGGCAGGTGGTGGACCAGACCAAGTACAAGGACTACCAGGAGGTGGGCATCATCCACCA 
               
               
                   
               
               
                 GCACAACAACTCGGGCTTCGTGGGCTACCTCGCCCCCACCATGCGCGAGGGACAGGCCTACCCCGCC 
               
               
                   
               
               
                 AACTTCCCCTATCCGCTCATAGGCAAGACCGCGGTCGACAGCATCACCCAGAAAAAGTTCCTCTGCG 
               
               
                   
               
               
                 ACCGCACCCTCTGGCGCATCCCCTTCTCCAGCAACTTCATGTCCATGGGTGCGCTCTCGGACCTGGGC 
               
               
                   
               
               
                 CAGAACTTGCTCTACGCCAACTCCGCCCACGCCCTCGACATGACCTTCGAGGTCGACCCCATGGACG 
               
               
                   
               
               
                 AGCCCACCCTTCTCTATGTTCTGTTCGAAGTCTTTGACGTGGTCCGGGTCCACCAGCCGCACCGCGGC 
               
               
                   
               
               
                 GTCATCGAGACCGTGTACCTGCGTACGCCCTTCTCGGCCGGCAACGCCACCACCTAAAGAAGCAAGC 
               
               
                   
               
               
                 CGCAGTCATCGCCGCCTGCATGCCGTCGGGTTCCACCGAGCAAGAGCTCAGGGCCATCGTCAGAGAC 
               
               
                   
               
               
                 CTGGGATGCGGGCCCTATTTTTTGGGCACCTTCGACAAGCGCTTCCCTGGCTTTGTCTCCCCACACAA 
               
               
                   
               
               
                 GCTGGCCTGCGCCATCGTCAACACGGCCGGCCGCGAGACCGGGGGCGTGCACTGGCTGGCCTTCGCC 
               
               
                   
               
               
                 TGGAACCCGCGCTCCAAAACATGCTTCCTCTTTGACCCCTTCGGCTTTTCGGACCAGCGGCTCAAGCA 
               
               
                   
               
               
                 AATCTACGAGTTCGAGTACGAGGGCTTGCTGCGTCGCAGCGCCATCGCCTCCTCGCCCGACCGCTGC 
               
               
                   
               
               
                 GTCACCCTCGAAAAGTCCACCCAGACCGTGCAGGGGCCCGACTCGGCCGCCTGCGGTCTCTTCTGCT 
               
               
                   
               
               
                 GCATGTTTCTGCACGCCTTTGTGCACTGGCCTCAGAGTCCCATGGACCGCAACCCCACCATGAACTTG 
               
               
                   
               
               
                 CTGACGGGGGTGCCCAACTCCATGCTCCAGAGCCCCCAGGTCGAGCCCACCCTGCGCCGCAACCAGG 
               
               
                   
               
               
                 AGCAGCTCTACAGCTTCCTGGAGCGCCACTCGCCTTACTTCCGCCGCCACAGCGCACAGATCAGGAG 
               
               
                   
               
               
                 GGCCACCTCCTTCTGCCACTTGCAAGAGATGCAAGAAGGGTAATAACGATGTACACACTTTTTTTCTC 
               
               
                   
               
               
                 AATAAATGGCATCTTTTTATTTATACAAGCTCTCTGGGGTATTCATTTCCCACCACCACCCGCCGTTGT 
               
               
                   
               
               
                 CGCCATCTGGCTCTATTTAGAAATCGAAAGGGTTCTGCCGGGAGTCGCCGTGCGCCACGGGCAGGGA 
               
               
                   
               
               
                 CACGTTGCGATACTGGTAGCGGGTGCCCCACTTGAACTCGGGCACCACCAGGCGAGGCAGCTCGGGG 
               
               
                   
               
               
                 AAGTTTTCGCTCCACAGGCTGCGGGTCAGCACCAGCGCGTTCATCAGGTCGGGCGCCGAGATCTTGA 
               
               
                   
               
               
                 AGTCGCAGTTGGGGCCGCCGCCCTGCGCGCGCGAGTTGCGGTACACCGGGTTGCAGCACTGGAACAC 
               
               
                   
               
               
                 CAACAGCGCCGGGTGCTTCACGCTGGCCAGCACGCTGCGGTCGGAGATCAGCTCGGCGTCCAGGTCC 
               
               
                   
               
               
                 TCCGCGTTGCTCAGCGCGAACGGGGTCATCTTGGGCACTTGCCGCCCCAGGAAGGGCGCGTGCCCCG 
               
               
                   
               
               
                 GTTTCGAGTTGCAGTCGCAGCGCAGCGGGATCAGCAGGTGCCCGTGCCCGGACTCGGCGTTGGGGTA 
               
               
                   
               
               
                 CAGCGCGCGCATGAAGGCCTGCATCTGGCGGAAGGCCATCTGGGCCTTGGCGCCCTCCGAGAAGAAC 
               
               
                   
               
               
                 ATGCCGCAGGACTTGCCCGAGAACTGGTTTGCGGGGCAGCTGGCGTCGTGCAGGCAGCAGCGCGCGT 
               
               
                   
               
               
                 CGGTGTTGGCGATCTGCACCACGTTGCGCCCCCACCGGTTCTTCACGATCTTGGCCTTGGACGATTGC 
               
               
                   
               
               
                 TCCTTCAGCGCGCGCTGCCCGTTCTCGCTGGTCACATCCATCTCGATCACATGTTCCTTGTTCACCATG 
               
               
                   
               
               
                 CTGCTGCCGTGCAGACACTTCAGCTCGCCCTCCGTCTCGGTGCAGCGGTGCTGCCACAGCGCGCAGC 
               
               
                   
               
               
                 CCGTGGGCTCGAAAGACTTGTAGGTCACCTCCGCGAAGGACTGCAGGTACCCCTGCAAAAAGCGGCC 
               
               
                   
               
               
                 CATCATGGTCACGAAGGTCTTGTTGCTGCTGAAGGTCAGCTGCAGCCCGCGGTGCTCCTCGTTCAGCC 
               
               
                   
               
               
                 AGGTCTTGCACACGGCCGCCAGCGCCTCCACCTGGTCGGGCAGCATCTTGAAGTTCACCTTCAGCTCA 
               
               
                   
               
               
                 TTCTCCACGTGGTACTTGTCCATCAGCGTGCGCGCCGCCTCCATGCCCTTCTCCCAGGCCGACACCAG 
               
               
                   
               
               
                 CGGCAGGCTCACGGGGTTCTTCACCATCACCGTGGCCGCCGCCTCCGCCGCGCTTTCGCTTTCCGCCC 
               
               
                   
               
               
                 CGCTGTTCTCTTCCTCTTCCTCCTCTTCCTCGCCGCCGCCCACTCGCAGCCCCCGCACCACGGGGTCGT 
               
               
                   
               
               
                 CTTCCTGCAGGCGCTGCACCTTGCGCTTGCCGTTGCGCCCCTGCTTGATGCGCACGGGCGGGTTGCTG 
               
               
                   
               
               
                 AAGCCCACCATCACCAGCGCGGCCTCTTCTTGCTCGTCCTCGCTGTCCAGAATGACCTCCGGGGAGG 
               
               
                   
               
               
                 GGGGGTTGGTCATCCTCAGTACCGAGGCACGCTTCTTTTTCTTCCTGGGGGCGTTCGCCAGCTCCGCG 
               
               
                   
               
               
                 GCTGCGGCCGCTGCCGAGGTCGAAGGCCGAGGGCTGGGCGTGCGCGGCACCAGCGCGTCCTGCGAG 
               
               
                   
               
               
                 CCGTCCTCGTCCTCCTCGGACTCGAGACGGAGGCGGGCCCGCTTCTTCGGGGGCGCGCGGGGCGGCG 
               
               
                   
               
               
                 GAGGCGGCGGCGGCGACGGAGACGGGGACGAGACATCGTCCAGGGTGGGTGGACGGCGGGCCGCG 
               
               
                   
               
               
                 CCGCGTCCGCGCTCGGGGGTGGTCTCGCGCTGGTCCTCTTCCCGACTGGCCATCTCCCACTGCTCCTT 
               
               
                   
               
               
                 CTCCTATAGGCAGAAAGAGATCATGGAGTCTCTCATGCGAGTCGAGAAGGAGGAGGACAGCCTAAC 
               
               
                   
               
               
                 CGCCCCCTCTGAGCCCTCCACCACCGCCGCCACCACCGCCAATGCCGCCGCGGACGACGCGCCCACC 
               
               
                   
               
               
                 GAGACCACCGCCAGTACCACCCTCCCCAGCGACGCACCCCCGCTCGAGAATGAAGTGCTGATCGAGC 
               
               
                   
               
               
                 AGGACCCGGGTTTTGTGAGCGGAGAGGAGGATGAGGTGGATGAGAAGGAGAAGGAGGAGGTCGCC 
               
               
                   
               
               
                 GCCTCAGTGCCAAAAGAGGATAAAAAGCAAGACCAGGACGACGCAGATAAGGATGAGACAGCAGT 
               
               
                   
               
               
                 CGGGCGGGGGAACGGAAGCCATGATGCTGATGACGGCTACCTAGACGTGGGAGACGACGTGCTGCT 
               
               
                   
               
               
                 TAAGCACCTGCACCGCCAGTGCGTCATCGTCTGCGACGCGCTGCAGGAGCGCTGCGAAGTGCCCCTG 
               
               
                   
               
               
                 GACGTGGCGGAGGTCAGCCGCGCCTACGAGCGGCACCTCTTCGCGCCGCACGTGCCCCCCAAGCGCC 
               
               
                   
               
               
                 GGGAGAACGGCACCTGCGAGCCCAACCCGCGTCTCAACTTCTACCCGGTCTTCGCGGTACCCGAGGT 
               
               
                   
               
               
                 GCTGGCCACCTACCACATCTTTTTCCAAAACTGCAAGATCCCCCTCTCCTGCCGCGCCAACCGCACCC 
               
               
                   
               
               
                 GCGCCGACAAAACCCTGACCCTGCGGCAGGGCGCCCACATACCTGATATCGCCTCTCTGGAGGAAGT 
               
               
                   
               
               
                 GCCCAAGATCTTCGAGGGTCTCGGTCGCGACGAGAAACGGGCGGCGAACGCTCTGCACGGAGACAG 
               
               
                   
               
               
                 CGAAAACGAGAGTCACTCGGGGGTGCTGGTGGAGCTCGAGGGCGACAACGCGCGCCTGGCCGTACT 
               
               
                   
               
               
                 CAAGCGCAGCATAGAGGTCACCCACTTTGCCTACCCGGCGCTCAACCTGCCCCCCAAGGTCATGAGT 
               
               
                   
               
               
                 GTGGTCATGGGCGAGCTCATCATGCGCCGCGCCCAGCCCCTGGCCGCGGATGCAAACTTGCAAGAGT 
               
               
                   
               
               
                 CCTCCGAGGAAGGCCTGCCCGCGGTCAGCGACGAGCAGCTGGCGCGCTGGCTGGAGACCCGCGACC 
               
               
                   
               
               
                 CCGCGCAGCTGGAGGAGCGGCGCAAGCTCATGATGGCCGCGGTGCTGGTCACCGTGGAGCTCGAGT 
               
               
                   
               
               
                 GTCTGCAGCGCTTCTTCGCGGACCCCGAGATGCAGCGCAAGCTCGAGGAGACCCTGCACTACACCTT 
               
               
                   
               
               
                 CCGCCAGGGCTACGTGCGCCAGGCCTGCAAGATCTCCAACGTGGAGCTCTGCAACCTGGTCTCCTAC 
               
               
                   
               
               
                 CTGGGCATCCTGCACGAGAACCGCCTCGGGCAGAACGTCCTGCACTCCACCCTCAAAGGGGAGGCGC 
               
               
                   
               
               
                 GCCGCGACTACATCCGCGACTGCGCCTACCTCTTCCTCTGCTACACCTGGCAGACGGCCATGGGGGTC 
               
               
                   
               
               
                 TGGCAGCAGTGCCTGGAGGAGCGCAACCTCAAGGAGCTGGAAAAGCTCCTCAAGCGCACCCTCAGG 
               
               
                   
               
               
                 GACCTCTGGACGGGCTTCAACGAGCGCTCGGTGGCCGCCGCGCTGGCGGACATCATCTTTCCCGAGC 
               
               
                   
               
               
                 GCCTGCTCAAGACCCTGCAGCAGGGCCTGCCCGACTTCACCAGCCAGAGCATGCTGCAGAACTTCAG 
               
               
                   
               
               
                 GACTTTCATCCTGGAGCGCTCGGGCATCCTGCCGGCCACTTGCTGCGCGCTGCCCAGCGACTTCGTGC 
               
               
                   
               
               
                 CCATCAAGTACAGGGAGTGCCCGCCGCCGCTCTGGGGCCACTGCTACCTCTTCCAGCTGGCCAACTA 
               
               
                   
               
               
                 CCTCGCCTACCACTCGGACCTCATGGAAGACGTGAGCGGCGAGGGCCTGCTCGAGTGCCACTGCCGC 
               
               
                   
               
               
                 TGCAACCTCTGCACGCCCCACCGCTCTCTAGTCTGCAACCCGCAGCTGCTCAGCGAGAGTCAGATTAT 
               
               
                   
               
               
                 CGGTACCTTCGAGCTGCAGGGTCCCTCGCCTGACGAGAAGTCCGCGGCTCCAGGGCTGAAACTCACT 
               
               
                   
               
               
                 CCGGGGCTGTGGACTTCCGCCTACCTACGCAAATTTGTACCTGAGGACTACCACGCCCACGAGATCA 
               
               
                   
               
               
                 GGTTCTACGAAGACCAATCCCGCCCGCCCAAGGCGGAGCTCACCGCCTGCGTCATCACCCAGGGGCA 
               
               
                   
               
               
                 CATCCTGGGCCAATTGCAAGCCATCAACAAAGCCCGCCGAGAGTTCTTGCTGAAAAAGGGTCGGGGG 
               
               
                   
               
               
                 GTGTACCTGGACCCCCAGTCCGGCGAGGAGCTAAACCCGCTACCCCCGCCGCCGCCCCAGCAGCGGG 
               
               
                   
               
               
                 ACCTTGCTTCCCAGGATGGCACCCAGAAAGAAGCAGCAGCCGCCGCCGCCGCCGCAGCCATACATGC 
               
               
                   
               
               
                 TTCTGGAGGAAGAGGAGGAGGACTGGGACAGTCAGGCAGAGGAGGTTTCGGACGAGGAGCAGGAG 
               
               
                   
               
               
                 GAGATGATGGAAGACTGGGAGGAGGACAGCAGCCTAGACGAGGAAGCTTCAGAGGCCGAAGAGGT 
               
               
                   
               
               
                 GGCAGACGCAACACCATCGCCCTCGGTCGCAGCCCCCTCGCCGGGGCCCCTGAAATCCTCCGAACCC 
               
               
                   
               
               
                 AGCACCAGCGCTATAACCTCCGCTCCTCCGGCGCCGGCGCCACCCGCCCGCAGACCCAACCGTAGAT 
               
               
                   
               
               
                 GGGACACCACAGGAACCGGGGTCGGTAAGTCCAAGTGCCCGCCGCCGCCACCGCAGCAGCAGCAGC 
               
               
                   
               
               
                 AGCAGCGCCAGGGCTACCGCTCGTGGCGCGGGCACAAGAACGCCATAGTCGCCTGCTTGCAAGACTG 
               
               
                   
               
               
                 CGGGGGCAACATCTCTTTCGCCCGCCGCTTCCTGCTATTCCACCACGGGGTCGCCTTTCCCCGCAATG 
               
               
                   
               
               
                 TCCTGCATTACTACCGTCATCTCTACAGCCCCTACTGCAGCGGCGACCCAGAGGCGGCAGCGGCAGC 
               
               
                   
               
               
                 CACAGCGGCGACCACCACCTAGGAAGATATCCTCCGCGGGCAAGACAGCGGCAGCAGCGGCCAGGA 
               
               
                   
               
               
                 GACCCGCGGCAGCAGCGGCGGGAGCGGTGGGCGCACTGCGCCTCTCGCCCAACGAACCCCTCTCGAC 
               
               
                   
               
               
                 CCGGGAGCTCAGACACAGGATCTTCCCCACTTTGTATGCCATCTTCCAACAGAGCAGAGGCCAGGAG 
               
               
                   
               
               
                 CAGGAGCTGAAAATAAAAAACAGATCTCTGCGCTCCCTCACCCGCAGCTGTCTGTATCACAAAAGCG 
               
               
                   
               
               
                 AAGATCAGCTTCGGCGCACGCTGGAGGACGCGGAGGCACTCTTCAGCAAATACTGCGCGCTCACTCT 
               
               
                   
               
               
                 TAAAGACTAGCTCCGCGCCCTTCTCGAATTTAGGCGGGAGAAAACTACGTCATCGCCGGCCGCCGCC 
               
               
                   
               
               
                 CAGCCCGCCCAGCCGAGATGAGCAAAGAGATTCCCACGCCATACATGTGGAGCTACCAGCCGCAGA 
               
               
                   
               
               
                 TGGGACTCGCGGCGGGAGCGGCCCAGGACTACTCCACCCGCATGAACTACATGAGCGCGGGACCCC 
               
               
                   
               
               
                 ACATGATCTCACAGGTCAACGGGATCCGCGCCCAGCGAAACCAAATACTGCTGGAACAGGCGGCCA 
               
               
                   
               
               
                 TCACCGCCACGCCCCGCCATAATCTCAACCCCCGAAATTGGCCCGCCGCCCTCGTGTACCAGGAAAC 
               
               
                   
               
               
                 CCCCTCCGCCACCACCGTACTACTTCCGCGTGACGCCCAGGCCGAAGTCCAGATGACTAACTCAGGG 
               
               
                   
               
               
                 GCGCAGCTCGCGGGCGGCTTTCGTCACGGGGCGCGGCCGCTCCGACCAGGTATAAGACACCTGATGA 
               
               
                   
               
               
                 TCAGAGGCCGAGGTATCCAGCTCAACGACGAGTCGGTGAGCTCTTCGCTCGGTCTCCGTCCGGACGG 
               
               
                   
               
               
                 AACTTTCCAGCTCGCCGGATCCGGCCGCTCTTCGTTCACGCCCCGCCAGGCGTACCTGACTCTGCAGA 
               
               
                   
               
               
                 CCTCGTCCTCGGAGCCCCGCTCCGGCGGCATCGGAACCCTCCAGTTCGTGGAGGAGTTCGTGCCCTCG 
               
               
                   
               
               
                 GTCTACTTCAACCCCTTCTCGGGACCTCCCGGACGCTACCCCGACCAGTTCATTCCGAACTTTGACGC 
               
               
                   
               
               
                 GGTGAAGGACTCGGCGGACGGCTACGACTGAATGTCAGGTGTCGAGGCAGAGCAGCTTCGCCTGAG 
               
               
                   
               
               
                 ACACCTCGAGCACTGCCGCCGCCACAAGTGCTTCGCCCGCGGTTCTGGTGAGTTCTGCTACTTTCAGC 
               
               
                   
               
               
                 TACCCGAGGAGCATACCGAGGGGCCGGCGCACGGCGTCCGCCTGACCACCCAGGGCGAGGTTACCT 
               
               
                   
               
               
                 GTTCCCTCATCCGGGAGTTTACCCTCCGTCCCCTGCTAGTGGAGCGGGAGCGGGGTCCCTGTGTCCTA 
               
               
                   
               
               
                 ACTATCGCCTGCAACTGCCCTAACCCTGGATTACATCAAGATCTTTGCTGTCATCTCTGTGCTGAGTTT 
               
               
                   
               
               
                 AATAAACGCTGAGATCAGAATCTACTGGGGCTCCTGTCGCCATCCTGTGAACGCCACCGTCTTCACCC 
               
               
                   
               
               
                 ACCCCGACCAGGCCCAGGCGAACCTCACCTGCGGTCTGCATCGGAGGGCCAAGAAGTACCTCACCTG 
               
               
                   
               
               
                 GTACTTCAACGGCACCCCCTTTGTGGTTTACAACAGCTTCGACGGGGACGGAGTCTCCCTGAAAGAC 
               
               
                   
               
               
                 CAGCTCTCCGGTCTCAGCTACTCCATCCACAAGAACACCACCCTCCAACTCTTCCCTCCCTACCTGCC 
               
               
                   
               
               
                 GGGAACCTACGAGTGCGTCACCGGCCGCTGCACCCACCTCACCCGCCTGATCGTAAACCAGAGCTTT 
               
               
                   
               
               
                 CCGGGAACAGATAACTCCCTCTTCCCCAGAACAGGAGGTGAGCTCAGGAAACTCCCCGGGGACCAG 
               
               
                   
               
               
                 GGCGGAGACGTACCTTCGACCCTTGTGGGGTTAGGATTTTTTATTACCGGGTTGCTGGCTCTTTTAAT 
               
               
                   
               
               
                 CAAAGTTTCCTTGAGATTTGTTCTTTCCTTCTACGTGTATGAACACCTCAACCTCCAATAACTCTACCC 
               
               
                   
               
               
                 TTTCTTCGGAATCAGGTGACTTCTCTGAAATCGGGCTTGGTGTGCTGCTTACTCTGTTGATTTTTTTCC 
               
               
                   
               
               
                 TTATCATACTCAGCCTTCTGTGCCTCAGGCTCGCCGCCTGCTGCGCACACATCTATATCTACTGCTGGT 
               
               
                   
               
               
                 TGCTCAAGTGCAGGGGTCGCCACCCAAGATGAACAGGTACATGGTCCTATCGATCCTAGGCCTGCTG 
               
               
                   
               
               
                 GCCCTGGCGGCCTGCAGCGCCGCCAAAAAAGAGATTACCTTTGAGGAGCCCGCTTGCAATGTAACTT 
               
               
                   
               
               
                 TCAAGCCCGAGGGTGACCAATGCACCACCCTCGTCAAATGCGTTACCAATCATGAGAGGCTGCGCAT 
               
               
                   
               
               
                 CGACTACAAAAACAAAACTGGCCAGTTTGCGGTCTATAGTGTGTTTACGCCCGGAGACCCCTCTAAC 
               
               
                   
               
               
                 TACTCTGTCACCGTCTTCCAGGGCGGACAGTCTAAGATATTCAATTACACTTTCCCTTTTTATGAGTTA 
               
               
                   
               
               
                 TGCGATGCGGTCATGTACATGTCAAAACAGTACAACCTGTGGCCTCCCTCTCCCCAGGCGTGTGTGG 
               
               
                   
               
               
                 AAAATACTGGGTCTTACTGCTGTATGGCTTTCGCAATCACTACGCTCGCTCTAATCTGCACGGTGCTA 
               
               
                   
               
               
                 TACATAAAATTCAGGCAGAGGCGAATCTTTATCGATGAAAAGAAAATGCCTTGATCGCTAACACCGG 
               
               
                   
               
               
                 CTTTCTATCTGCAGAATGAATGCAATCACCTCCCTACTAATCACCACCACCCTCCTTGCGATTGCCCA 
               
               
                   
               
               
                 TGGGTTGACACGAATCGAAGTGCCAGTGGGGTCCAATGTCACCATGGTGGGCCCCGCCGGCAATTCC 
               
               
                   
               
               
                 ACCCTCATGTGGGAAAAATTTGTCCGCAATCAATGGGTTCATTTCTGCTCTAACCGAATCAGTATCAA 
               
               
                   
               
               
                 GCCCAGAGCCATCTGCGATGGGCAAAATCTAACTCTGATCAATGTGCAAATGATGGATGCTGGGTAC 
               
               
                   
               
               
                 TATTACGGGCAGCGGGGAGAAATCATTAATTACTGGCGACCCCACAAGGACTACATGCTGCATGTAG 
               
               
                   
               
               
                 TCGAGGCACTTCCCACTACCACCCCCACTACCACCTCTCCCACCACCACCACCACTACTACTACTACT 
               
               
                   
               
               
                 ACTACTACTACTACTACTACCACTACCGCTGCCCGCCATACCCGCAAAAGCACCATGATTAGCACAA 
               
               
                   
               
               
                 AGCCCCCTCGTGCTCACTCCCACGCCGGCGGGCCCATCGGTGCGACCTCAGAAACCACCGAGCTTTG 
               
               
                   
               
               
                 CTTCTGCCAATGCACTAACGCCAGCGCTCATGAACTGTTCGACCTGGAGAATGAGGATGTCCAGCAG 
               
               
                   
               
               
                 AGCTCCGCTTGCCTGACCCAGGAGGCTGTGGAGCCCGTTGCCCTGAAGCAGATCGGTGATTCAATAA 
               
               
                   
               
               
                 TTGACTCTTCTTCTTTTGCCACTCCCGAATACCCTCCCGATTCTACTTTCCACATCACGGGTACCAAAG 
               
               
                   
               
               
                 ACCCTAACCTCTCTTTCTACCTGATGCTGCTGCTCTGTATCTCTGTGGTCTCTTCCGCGCTGATGTTAC 
               
               
                   
               
               
                 TGGGGATGTTCTGCTGCCTGATCTGCCGCAGAAAGAGAAAAGCTCGCTCTCAGGGCCAACCACTGAT 
               
               
                   
               
               
                 GCCCTTCCCCTACCCCCCGGATTTTGCAGATAACAAGATATGAGCTCGCTGCTGACACTAACCGCTTT 
               
               
                   
               
               
                 ACTAGCCTGCGCTCTAACCCTTGTCGCTTGCGACTCGAGATTCCACAATGTCACAGCTGTGGCAGGAG 
               
               
                   
               
               
                 AAAATGTTACTTTCAACTCCACGGCCGATACCCAGTGGTCGTGGAGTGGCTCAGGTAGCTACTTAACT 
               
               
                   
               
               
                 ATCTGCAATAGCTCCACTTCCCCCGGCATATCCCCAACCAAGTACCAATGCAATGCCAGCCTGTTCAC 
               
               
                   
               
               
                 CCTCATCAACGCTTCCACCCTGGACAATGGACTCTATGTAGGCTATGTACCCTTTGGTGGGCAAGGAA 
               
               
                   
               
               
                 AGACCCACGCTTACAACCTGGAAGTTCGCCAGCCCAGAACCACTACCCAAGCTTCTCCCACCACCAC 
               
               
                   
               
               
                 CACCACCACCACCATCACCAGCAGCAGCAGCAGCAGCAGCCACAGCAGCAGCAGCAGATTATTGAC 
               
               
                   
               
               
                 TTTGGTTTTGGCCAGCTCATCTGCCGCTACCCAGGCCATCTACAGCTCTGTGCCCGAAACCACTCAGA 
               
               
                   
               
               
                 TCCACCGCCCAGAAACGACCACCGCCACCACCCTACACACCTCCAGCGATCAGATGCCGACCAACAT 
               
               
                   
               
               
                 CACCCCCTTGGCTCTTCAAATGGGACTTACAAGCCCCACTCCAAAACCAGTGGATGCGGCCGAGGTC 
               
               
                   
               
               
                 TCCGCCCTCGTCAATGACTGGGCGGGGCTGGGAATGTGGTGGTTCGCCATAGGCATGATGGCGCTCT 
               
               
                   
               
               
                 GCCTGCTTCTGCTCTGGCTCATCTGCTGCCTCCACCGCAGGCGAGCCAGACCCCCCATCTATAGACCC 
               
               
                   
               
               
                 ATCATTGTCCTGAACCCCGATAATGATGGGATCCATAGATTGGATGGCCTGAAAAACCTACTTTTTTC 
               
               
                   
               
               
                 TTTTACAGTATGATAAATTGAGACATGCCTCGCATTTTCTTGTACATGTTCCTTCTCCCACCTTTTCTG 
               
               
                   
               
               
                 GGGTGTTCTACGCTGGCCGCTGTGTCTCACCTGGAGGTAGACTGCCTCTCACCCTTCACTGTCTACCT 
               
               
                   
               
               
                 GCTTTACGGATTGGTCACCCTCACTCTCATCTGCAGCCTAATCACAGTAATCATCGCCTTCATCCAGT 
               
               
                   
               
               
                 GCATTGATTACATCTGTGTGCGCCTCGCATACTTCAGACACCACCCGCAGTACCGAGACAGGAACAT 
               
               
                   
               
               
                 TGCCCAACTTCTAAGACTGCTCTAATCATGCATAAGACTGTGATCTGCCTTCTGATCCTCTGCATCCT 
               
               
                   
               
               
                 GCCCACCCTCACCTCCTGCCAGTACACCACAAAATCTCCGCGCAAAAGACATGCCTCCTGCCGCTTCA 
               
               
                   
               
               
                 CCCAACTGTGGAATATACCCAAATGCTACAACGAAAAGAGCGAGCTCTCCGAAGCTTGGCTGTATGG 
               
               
                   
               
               
                 GGTCATCTGTGTCTTAGTTTTCTGCAGCACTGTCTTTGCCCTCATAATCTACCCCTACTTTGATTTGGG 
               
               
                   
               
               
                 ATGGAACGCGATCGATGCCATGAATTACCCCACCTTTCCCGCACCCGAGATAATTCCACTGCGACAA 
               
               
                   
               
               
                 GTTGTACCCGTTGTCGTTAATCAACGCCCCCCATCCCCTACGCCCACTGAAATCAGCTACTTTAACCT 
               
               
                   
               
               
                 AACAGGCGGAGATGACTGACGCCCTAGATCTAGAAATGGACGGCATCAGTACCGAGCAGCGTCTCCT 
               
               
                   
               
               
                 AGAGAGGCGCAGGCAGGCGGCTGAGCAAGAGCGCCTCAATCAGGAGCTCCGAGATCTCGTTAACCT 
               
               
                   
               
               
                 GCACCAGTGCAAAAGAGGCATCTTTTGTCTGGTAAAGCAGGCCAAAGTCACCTACGAGAAGACCGG 
               
               
                   
               
               
                 CAACAGCCACCGCCTCAGTTACAAATTGCCCACCCAGCGCCAGAAGCTGGTGCTCATGGTGGGTGAG 
               
               
                   
               
               
                 AATCCCATCACCGTCACCCAGCACTCGGTAGAGACCGAGGGGTGTCTGCACTCCCCCTGTCGGGGTC 
               
               
                   
               
               
                 CAGAAGACCTCTGCACCCTGGTAAAGACCCTGTGCGGTCTCAGAGATTTAGTCCCCTTTAACTAATCA 
               
               
                   
               
               
                 AACACTGGAATCAATAAAAAGAATCACTTACTTAAAATCAGACAGCAGGTCTCTGTCCAGTTTATTC 
               
               
                   
               
               
                 AGCAGCACCTCCTTCCCCTCCTCCCAACTCTGGTACTCCAAACGCCTTCTGGCGGCAAACTTCCTCCA 
               
               
                   
               
               
                 CACCCTGAAGGGAATGTCAGATTCTTGCTCCTGTCCCTCCGCACCCACTATCTTCATGTTGTTGCAGA 
               
               
                   
               
               
                 TGAAGCGCACCAAAACGTCTGACGAGAGCTTCAACCCCGTGTACCCCTATGACACGGAAAGCGGCCC 
               
               
                   
               
               
                 TCCCTCCGTCCCTTTCCTCACCCCTCCCTTCGTGTCTCCCGATGGATTCCAAGAAAGTCCCCCCGGGGT 
               
               
                   
               
               
                 CCTGTCTCTGAACCTGGCCGAGCCCCTGGTCACTTCCCACGGCATGCTCGCCCTGAAAATGGGAAGT 
               
               
                   
               
               
                 GGCCTCTCCCTGGACGACGCTGGCAACCTCACCTCTCAAGATATCACCACCGCTAGCCCTCCCCTCAA 
               
               
                   
               
               
                 AAAAACCAAGACCAACCTCAGCCTAGAAACCTCATCCCCCCTAACTGTGAGCACCTCAGGCGCCCTC 
               
               
                   
               
               
                 ACCGTAGCAGCCGCCGCTCCCCTGGCGGTGGCCGGCACCTCCCTCACCATGCAATCAGAGGCCCCCC 
               
               
                   
               
               
                 TGACAGTACAGGATGCAAAACTCACCCTGGCCACCAAAGGCCCCCTGACCGTGTCTGAAGGCAAACT 
               
               
                   
               
               
                 GGCCTTGCAAACATCGGCCCCGCTGACGGCCGCTGACAGCAGCACCCTCACAGTCAGTGCCACACCA 
               
               
                   
               
               
                 CCCCTTAGCACAAGCAATGGCAGCTTGGGTATTGACATGCAAGCCCCCATTTACACCACCAATGGAA 
               
               
                   
               
               
                 AACTAGGACTTAACTTTGGCGCTCCCCTGCATGTGGTAGACAGCCTAAATGCACTGACTGTAGTTACT 
               
               
                   
               
               
                 GGCCAAGGTCTTACGATAAACGGAACAGCCCTACAAACTAGAGTCTCAGGTGCCCTCAACTATGACA 
               
               
                   
               
               
                 CATCAGGAAACCTAGAATTGAGAGCTGCAGGGGGTATGCGAGTTGATGCAAATGGTCAACTTATCCT 
               
               
                   
               
               
                 TGATGTAGCTTACCCATTTGATGCACAAAACAATCTCAGCCTTAGGCTTGGACAGGGACCCCTGTTTG 
               
               
                   
               
               
                 TTAACTCTGCCCACAACTTGGATGTTAACTACAACAGAGGCCTCTACCTGTTCACATCTGGAAATACC 
               
               
                   
               
               
                 AAAAAGCTAGAAGTTAATATCAAAACAGCCAAGGGTCTCATTTATGATGACACTGCTATAGCAATCA 
               
               
                   
               
               
                 ATGCGGGTGATGGGCTACAGTTTGACTCAGGCTCAGATACAAATCCATTAAAAACTAAACTTGGATT 
               
               
                   
               
               
                 AGGACTGGATTATGACTCCAGCAGAGCCATAATTGCTAAACTGGGAACTGGCCTAAGCTTTGACAAC 
               
               
                   
               
               
                 ACAGGTGCCATCACAGTAGGCAACAAAAATGATGACAAGCTTACCTTGTGGACCACACCAGACCCAT 
               
               
                   
               
               
                 CCCCTAACTGTAGAATCTATTCAGAGAAAGATGCTAAATTCACACTTGTTTTGACTAAATGCGGCAGT 
               
               
                   
               
               
                 CAGGTGTTGGCCAGCGTTTCTGTTTTATCTGTAAAAGGTAGCCTTGCGCCCATCAGTGGCACAGTAAC 
               
               
                   
               
               
                 TAGTGCTCAGATTGTCCTCAGATTTGATGAAAATGGAGTTCTACTAAGCAATTCTTCCCTTGACCCTC 
               
               
                   
               
               
                 AATACTGGAACTACAGAAAAGGTGACCTTACAGAGGGCACTGCATATACCAACGCAGTGGGATTTAT 
               
               
                   
               
               
                 GCCCAACCTCACAGCATACCCAAAAACACAGAGCCAAACTGCTAAAAGCAACATTGTAAGTCAGGTT 
               
               
                   
               
               
                 TACTTGAATGGGGACAAATCCAAACCCATGACCCTCACCATTACCCTCAATGGAACTAATGAAACAG 
               
               
                   
               
               
                 GAGATGCCACAGTAAGCACTTACTCCATGTCATTCTCATGGAACTGGAATGGAAGTAATTACATTAA 
               
               
                   
               
               
                 TGAAACGTTCCAAACCAACTCCTTCACCTTCTCCTACATCGCCCAAGAATAAAAAGCATGACGCTGTT 
               
               
                   
               
               
                 GATTTGATTCAATGTGTTTCTGTTTTATTTTCAAGCACAACAAAATCATTCAAGTCATTCTTCCATCTT 
               
               
                   
               
               
                 AGCTTAATAGACACAGTAGCTTAATAGACCCAGTAGTGCAAAGCCCCATTCTAGCTTATAACTAGTG 
               
               
                   
               
               
                 GAGAAGTACTCGCCTACATGGGGGTAGAGTCATAATCGTGCATCAGGATAGGGCGGTGGTGCTGCAG 
               
               
                   
               
               
                 CAGCGCGCGAATAAACTGCTGCCGCCGCCGCTCCGTCCTGCAGGAATACAACATGGCAGTGGTCTCC 
               
               
                   
               
               
                 TCAGCGATGATTCGCACCGCCCGCAGCATAAGGCGCCTTGTCCTCCGGGCACAGCAGCGCACCCTGA 
               
               
                   
               
               
                 TCTCACTTAAATCAGCACAGTAACTGCAGCACAGCACCACAATATTGTTCAAAATCCCACAGTGCAA 
               
               
                   
               
               
                 GGCGCTGTATCCAAAGCTCATGGCGGGGACCACAGAACCCACGTGGCCATCATACCACAAGCGCAG 
               
               
                   
               
               
                 GTAGATTAAGTGGCGACCCCTCATAAACACGCTGGACATAAACATTACCTCTTTTGGCATGTTGTAAT 
               
               
                   
               
               
                 TCACCACCTCCCGGTACCATATAAACCTCTGATTAAACATGGCGCCATCCACCACCATCCTAAACCAG 
               
               
                   
               
               
                 CTGGCCAAAACCTGCCCGCCGGCTATACACTGCAGGGAACCGGGACTGGAACAATGACAGTGGAGA 
               
               
                   
               
               
                 GCCCAGGACTCGTAACCATGGATCATCATGCTCGTCATGATATCAATGTTGGCACAACACAGGCACA 
               
               
                   
               
               
                 CGTGCATACACTTCCTCAGGATTACAAGCTCCTCCCGCGTTAGAACCATATCCCAGGGAACAACCCA 
               
               
                   
               
               
                 TTCCTGAATCAGCGTAAATCCCACACTGCAGGGAAGACCTCGCACGTAACTCACGTTGTGCATTGTC 
               
               
                   
               
               
                 AAAGTGTTACATTCGGGCAGCAGCGGATGATCCTCCAGTATGGTAGCGCGGGTTTCTGTCTCAAAAG 
               
               
                   
               
               
                 GAGGTAGACGATCCCTACTGTACGGAGTGCGCCGAGACAACCGAGATCGTGTTGGTCGTAGTGTCAT 
               
               
                   
               
               
                 GCCAAATGGAACGCCGGACGTAGTCATATTTCCTGAAGTCTTAGATCTCTCAACGCAGCACCAGCAC 
               
               
                   
               
               
                 CAACACTTCGCAGTGTAAAAGGCCAAGTGCCGAGAGAGTATATATAGGAATAAAAAGTGACGTAAA 
               
               
                   
               
               
                 CGGGCAAAGTCCAAAAAACGCCCAGAAAAACCGCACGCGAACCTACGCCCCGAAACGAAAGCCAAA 
               
               
                   
               
               
                 AAACACTAGACACTCCCTTCCGGCGTCAACTTCCGCTTTCCCACGCTACGTCACTTGCCCCAGTCAAA 
               
               
                   
               
               
                 CAAACTACATATCCCGAACTTCCAAGTCGCCACGCCCAAAACACCGCCTACACCTCCCCGCCCGCCG 
               
               
                   
               
               
                 GCCCGCCCCCAAACCCGCCTCCCGCCCCGCGCCCCGCCCCGCGCCGCCCATCTCATTATCATATTGGC 
               
               
                   
               
               
                 TTCAATCCAAAATAAGGTATATTATTGATGATGGTTTAAACGGATCCAATTCTTGAAGACGAAAGGG 
               
               
                   
               
               
                 CCTCGTGATACGCCTATTTTTATAGGTTAATGTCATGATAATAATGGTTTCTTAGACGTCAGGTGGCA 
               
               
                   
               
               
                 CTTTTCGGGGAAATGTGCGCGGAACCCCTATTTGTTTATTTTTCTAAATACATTCAAATATGTATCCGC 
               
               
                   
               
               
                 TCATGAGACAATAACCCTGATAAATGCTTCAATAATATTGAAAAAGGAAGAGTATGAGTATTCAACA 
               
               
                   
               
               
                 TTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTG 
               
               
                   
               
               
                 GTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACA 
               
               
                   
               
               
                 GCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTG 
               
               
                   
               
               
                 CTATGTGGCGCGGTATTATCCCGTGTTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATT 
               
               
                   
               
               
                 CTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAG 
               
               
                   
               
               
                 AGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATC 
               
               
                   
               
               
                 GGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTT 
               
               
                   
               
               
                 GGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGTAGCAATGG 
               
               
                   
               
               
                 CAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGA 
               
               
                   
               
               
                 CTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTG 
               
               
                   
               
               
                 CTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAA 
               
               
                   
               
               
                 GCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAG 
               
               
                   
               
               
                 ATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATATACT 
               
               
                   
               
               
                 TTAGATTGATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACG 
               
               
                   
               
               
                 TGAGTTTTCGTTCCACTGAGCGTCAGACCCCGTAGAAAAGATCAAAGGATCTTCTTGAGATCCTTTTT 
               
               
                   
               
               
                 TTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGAT 
               
               
                   
               
               
                 CAAGAGCTACCAACTCTTTTTCCGAAGGTAACTGGCTTCAGCAGAGCGCAGATACCAAATACTGTCC 
               
               
                   
               
               
                 TTCTAGTGTAGCCGTAGTTAGGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATACCTCGCTCTG 
               
               
                   
               
               
                 CTAATCCTGTTACCAGTGGCTGCTGCCAGTGGCGATAAGTCGTGTCTTACCGGGTTGGACTCAAGACG 
               
               
                   
               
               
                 ATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACGGGGGGTTCGTGCACACAGCCCAGCTTGGA 
               
               
                   
               
               
                 GCGAACGACCTACACCGAACTGAGATACCTACAGCGTGAGCTATGAGAAAGCGCCACGCTTCCCGA 
               
               
                   
               
               
                 AGGGAGAAAGGCGGACAGGTATCCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGGAGC 
               
               
                   
               
               
                 TTCCAGGGGGAAACGCCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGACTTGAGCGTCGA 
               
               
                   
               
               
                 TTTTTGTGATGCTCGTCAGGGGGGCGGAGCCTATGGAAAAACGCCAGCAACGCGGCCTTTTTACGGT 
               
               
                   
               
               
                 TCCTGGCCTTTTGCTGGCCTTGAAGCTGTCCCTGATGGTCGTCATCTACCTGCCTGGACAGCATGGCC 
               
               
                   
               
               
                 TGCAACGCGGGCATCCCGATGCCGCCGGAAGCGAGAAGAATCATAATGGGGAAGGCCATCCAGCCT 
               
               
                   
               
               
                 CGCGTCGCAGATCCGAATTCGTTTAAAC 
               
               
                   
               
               
                 Polynucleotide sequence encoding ChAd155#1390 backbone construct 
               
               
                 SEQ ID NO: 8 
                   
               
               
                 CATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGATGGGCGGCGCGGGGCG 
                   
               
               
                   
               
               
                 GGGCGCGGGGCGGGAGGCGGGTTTGGGGGCGGGCCGGCGGGCGGGGCGGTGTGGCGGAAGTGGAC 
               
               
                   
               
               
                 TTTGTAAGTGTGGCGGATGTGACTTGCTAGTGCCGGGCGCGGTAAAAGTGACGTTTTCCGTGCGCGA 
               
               
                   
               
               
                 CAACGCCCCCGGGAAGTGACATTTTTCCCGCGGTTTTTACCGGATGTTGTAGTGAATTTGGGCGTAAC 
               
               
                   
               
               
                 CAAGTAAGATTTGGCCATTTTCGCGGGAAAACTGAAACGGGGAAGTGAAATCTGATTAATTTTGCGT 
               
               
                   
               
               
                 TAGTCATACCGCGTAATATTTGTCTAGGGCCGAGGGACTTTGGCCGATTACGTGGAGGACTCGCCCA 
               
               
                   
               
               
                 GGTGTTTTTTGAGGTGAATTTCCGCGTTCCGGGTCAAAGTCTGCGTTTTATTATTATAGGATATCCCAT 
               
               
                   
               
               
                 TGCATACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTT 
               
               
                   
               
               
                 GACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATG 
               
               
                   
               
               
                 GAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCAT 
               
               
                   
               
               
                 TGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGT 
               
               
                   
               
               
                 GGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCT 
               
               
                   
               
               
                 ATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCC 
               
               
                   
               
               
                 TACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCA 
               
               
                   
               
               
                 ATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAG 
               
               
                   
               
               
                 TTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAA 
               
               
                   
               
               
                 TGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCCCTATCAGTGATAGAGATCT 
               
               
                   
               
               
                 CCCTATCAGTGATAGAGATCGTCGACGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT 
               
               
                   
               
               
                 CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGCGGCCGGGAACGGTGCA 
               
               
                   
               
               
                 TTGGAACGCGGATTCCCCGTGCCAAGAGTGAGATCTTCCGTTTATCTAGGTACCGGGCCCCCCCTCGA 
               
               
                   
               
               
                 GGTCGACGGTATCGATAAGCTTCACGCTGCCGCAAGCACTCAGGGCGCAAGGGCTGCTAAAGGAAG 
               
               
                   
               
               
                 CGGAACACGTAGAAAGCCAGTCCGCAGAAACGGTGCTGACCCCGGATGAATGTCAGCTACTGGGCT 
               
               
                   
               
               
                 ATCTGGACAAGGGAAAACGCAAGCGCAAAGAGAAAGCAGGTAGCTTGCAGTGGGCTTACATGGCGA 
               
               
                   
               
               
                 TAGCTAGACTGGGCGGTTTTATGGACAGCAAGCGAACCGGAATTGCCAGCTGGGGCGCCCTCTGGTA 
               
               
                   
               
               
                 AGGTTGGGAAGCCCTGCAAAGTAAACTGGATGGCTTTCTTGCCGCCAAGGATCTGATGGCGCAGGGG 
               
               
                   
               
               
                 ATCAAGATCTAACCAGGAGCTATTTAATGGCAACAGTTAACCAGCTGGTACGCAAACCACGTGCTCG 
               
               
                   
               
               
                 CAAAGTTGCGAAAAGCAACGTGCCTGCGCTGGAAGCATGCCCGCAAAAACGTGGCGTATGTACTCGT 
               
               
                   
               
               
                 GTATATACTACCACTCCTAAAAAACCGAACTCCGCGCTGCGTAAAGTATGCCGTGTTCGTCTGACTAA 
               
               
                   
               
               
                 CGGTTTCGAAGTGACTTCCTACATCGGTGGTGAAGGTCACAACCTGCAGGAGCACTCCGTGATCCTG 
               
               
                   
               
               
                 ATCCGTGGCGGTCGTGTTAAAGACCTCCCGGGTGTTCGTTACCACACCGTACGTGGTGCGCTTGACTG 
               
               
                   
               
               
                 CTCCGGCGTTAAAGACCGTAAGCAGGCTCGTTCCAAGTATGGCGTGAAGCGTCCTAAGGCTTAATGG 
               
               
                   
               
               
                 TAGATCTGATCAAGAGACAGGATGACGGTCGTTTCGCATGCTTGAACAAGATGGATTGCACGCAGGT 
               
               
                   
               
               
                 TCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTG 
               
               
                   
               
               
                 ATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGT 
               
               
                   
               
               
                 GCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCG 
               
               
                   
               
               
                 CAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCA 
               
               
                   
               
               
                 GGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGC 
               
               
                   
               
               
                 TGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACG 
               
               
                   
               
               
                 TACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCA 
               
               
                   
               
               
                 GCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCG 
               
               
                   
               
               
                 ATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTG 
               
               
                   
               
               
                 GGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCG 
               
               
                   
               
               
                 AATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTAT 
               
               
                   
               
               
                 CGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAA 
               
               
                   
               
               
                 CCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCC 
               
               
                   
               
               
                 GGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCGGGCT 
               
               
                   
               
               
                 CGATCCCCTCGGGGGGAATCAGAATTCAGTCGACAGCGGCCGCGATCTGCTGTGCCTTCTAGTTGCC 
               
               
                   
               
               
                 AGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTT 
               
               
                   
               
               
                 CCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGT 
               
               
                   
               
               
                 GGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCT 
               
               
                   
               
               
                 CTATGGCCGATCAGCGATCGCTGAGGTGGGTGAGTGGGCGTGGCCTGGGGTGGTCATGAAAATATAT 
               
               
                   
               
               
                 AAGTTGGGGGTCTTAGGGTCTCTTTATTTGTGTTGCAGAGACCGCCGGAGCCATGAGCGGGAGCAGC 
               
               
                   
               
               
                 AGCAGCAGCAGTAGCAGCAGCGCCTTGGATGGCAGCATCGTGAGCCCTTATTTGACGACGCGGATGC 
               
               
                   
               
               
                 CCCACTGGGCCGGGGTGCGTCAGAATGTGATGGGCTCCAGCATCGACGGCCGACCCGTCCTGCCCGC 
               
               
                   
               
               
                 AAATTCCGCCACGCTGACCTATGCGACCGTCGCGGGGACGCCGTTGGACGCCACCGCCGCCGCCGCC 
               
               
                   
               
               
                 GCCACCGCAGCCGCCTCGGCCGTGCGCAGCCTGGCCACGGACTTTGCATTCCTGGGACCACTGGCGA 
               
               
                   
               
               
                 CAGGGGCTACTTCTCGGGCCGCTGCTGCCGCCGTTCGCGATGACAAGCTGACCGCCCTGCTGGCGCA 
               
               
                   
               
               
                 GTTGGATGCGCTTACTCGGGAACTGGGTGACCTTTCTCAGCAGGTCATGGCCCTGCGCCAGCAGGTCT 
               
               
                   
               
               
                 CCTCCCTGCAAGCTGGCGGGAATGCTTCTCCCACAAATGCCGTTTAAGATAAATAAAACCAGACTCT 
               
               
                   
               
               
                 GTTTGGATTAAAGAAAAGTAGCAAGTGCATTGCTCTCTTTATTTCATAATTTTCCGCGCGCGATAGGC 
               
               
                   
               
               
                 CCTAGACCAGCGTTCTCGGTCGTTGAGGGTGCGGTGTATCTTCTCCAGGACGTGGTAGAGGTGGCTCT 
               
               
                   
               
               
                 GGACGTTGAGATACATGGGCATGAGCCCGTCCCGGGGGTGGAGGTAGCACCACTGCAGAGCTTCATG 
               
               
                   
               
               
                 CTCCGGGGTGGTGTTGTAGATGATCCAGTCGTAGCAGGAGCGCTGGGCATGGTGCCTAAAAATGTCC 
               
               
                   
               
               
                 TTCAGCAGCAGGCCGATGGCCAGGGGGAGGCCCTTGGTGTAAGTGTTTACAAAACGGTTAAGTTGGG 
               
               
                   
               
               
                 AAGGGTGCATTCGGGGAGAGATGATGTGCATCTTGGACTGTATTTTTAGATTGGCGATGTTTCCGCCC 
               
               
                   
               
               
                 AGATCCCTTCTGGGATTCATGTTGTGCAGGACCACCAGTACAGTGTATCCGGTGCACTTGGGGAATTT 
               
               
                   
               
               
                 GTCATGCAGCTTAGAGGGAAAAGCGTGGAAGAACTTGGAGACGCCTTTGTGGCCTCCCAGATTTTCC 
               
               
                   
               
               
                 ATGCATTCGTCCATGATGATGGCAATGGGCCCGCGGGAGGCAGCTTGGGCAAAGATATTTCTGGGGT 
               
               
                   
               
               
                 CGCTGACGTCGTAGTTGTGTTCCAGGGTGAGGTCGTCATAGGCCATTTTTACAAAGCGCGGGCGGAG 
               
               
                   
               
               
                 GGTGCCCGACTGGGGGATGATGGTCCCCTCTGGCCCTGGGGCGTAGTTGCCCTCGCAGATCTGCATTT 
               
               
                   
               
               
                 CCCAGGCCTTAATCTCGGAGGGGGGAATCATATCCACCTGCGGGGCGATGAAGAAAACGGTTTCCGG 
               
               
                   
               
               
                 AGCCGGGGAGATTAACTGGGATGAGAGCAGGTTTCTAAGCAGCTGTGATTTTCCACAACCGGTGGGC 
               
               
                   
               
               
                 CCATAAATAACACCTATAACCGGTTGCAGCTGGTAGTTTAGAGAGCTGCAGCTGCCGTCGTCCCGGA 
               
               
                   
               
               
                 GGAGGGGGGCCACCTCGTTGAGCATGTCCCTGACGCGCATGTTCTCCCCGACCAGATCCGCCAGAAG 
               
               
                   
               
               
                 GCGCTCGCCGCCCAGGGACAGCAGCTCTTGCAAGGAAGCAAAGTTTTTCAGCGGCTTGAGGCCGTCC 
               
               
                   
               
               
                 GCCGTGGGCATGTTTTTCAGGGTCTGGCTCAGCAGCTCCAGGCGGTCCCAGAGCTCGGTGACGTGCT 
               
               
                   
               
               
                 CTACGGCATCTCTATCCAGCATATCTCCTCGTTTCGCGGGTTGGGGCGACTTTCGCTGTAGGGCACCA 
               
               
                   
               
               
                 AGCGGTGGTCGTCCAGCGGGGCCAGAGTCATGTCCTTCCATGGGCGCAGGGTCCTCGTCAGGGTGGT 
               
               
                   
               
               
                 CTGGGTCACGGTGAAGGGGTGCGCTCCGGGCTGAGCGCTTGCCAAGGTGCGCTTGAGGCTGGTTCTG 
               
               
                   
               
               
                 CTGGTGCTGAAGCGCTGCCGGTCTTCGCCCTGCGCGTCGGCCAGGTAGCATTTGACCATGGTGTCATA 
               
               
                   
               
               
                 GTCCAGCCCCTCCGCGGCGTGTCCCTTGGCGCGCAGCTTGCCCTTGGAGGTGGCGCCGCACGAGGGG 
               
               
                   
               
               
                 CAGAGCAGGCTCTTGAGCGCGTAGAGCTTGGGGGCGAGGAAGACCGATTCGGGGGAGTAGGCGTCC 
               
               
                   
               
               
                 GCGCCGCAGACCCCGCACACGGTCTCGCACTCCACCAGCCAGGTGAGCTCGGGGCGCGCCGGGTCAA 
               
               
                   
               
               
                 AAACCAGGTTTCCCCCATGCTTTTTGATGCGTTTCTTACCTCGGGTCTCCATGAGGTGGTGTCCCCGCT 
               
               
                   
               
               
                 CGGTGACGAAGAGGCTGTCCGTGTCTCCGTAGACCGACTTGAGGGGTCTTTTCTCCAGGGGGGTCCC 
               
               
                   
               
               
                 TCGGTCTTCCTCGTAGAGGAACTCGGACCACTCTGAGACGAAGGCCCGCGTCCAGGCCAGGACGAAG 
               
               
                   
               
               
                 GAGGCTATGTGGGAGGGGTAGCGGTCGTTGTCCACTAGGGGGTCCACCTTCTCCAAGGTGTGAAGAC 
               
               
                   
               
               
                 ACATGTCGCCTTCCTCGGCGTCCAGGAAGGTGATTGGCTTGTAGGTGTAGGCCACGTGACCGGGGGT 
               
               
                   
               
               
                 TCCTGACGGGGGGGTATAAAAGGGGGTGGGGGCGCGCTCGTCGTCACTCTCTTCCGCATCGCTGTCT 
               
               
                   
               
               
                 GCGAGGGCCAGCTGCTGGGGTGAGTATTCCCTCTCGAAGGCGGGCATGACCTCCGCGCTGAGGTTGT 
               
               
                   
               
               
                 CAGTTTCCAAAAACGAGGAGGATTTGATGTTCACCTGTCCCGAGGTGATACCTTTGAGGGTACCCGC 
               
               
                   
               
               
                 GTCCATCTGGTCAGAAAACACGATCTTTTTATTGTCCAGCTTGGTGGCGAACGACCCGTAGAGGGCG 
               
               
                   
               
               
                 TTGGAGAGCAGCTTGGCGATGGAGCGCAGGGTCTGGTTCTTGTCCCTGTCGGCGCGCTCCTTGGCCGC 
               
               
                   
               
               
                 GATGTTGAGCTGCACGTACTCGCGCGCGACGCAGCGCCACTCGGGGAAGACGGTGGTGCGCTCGTCG 
               
               
                   
               
               
                 GGCACCAGGCGCACGCGCCAGCCGCGGTTGTGCAGGGTGACCAGGTCCACGCTGGTGGCGACCTCGC 
               
               
                   
               
               
                 CGCGCAGGCGCTCGTTGGTCCAGCAGAGACGGCCGCCCTTGCGCGAGCAGAAGGGGGGCAGGGGGT 
               
               
                   
               
               
                 CGAGCTGGGTCTCGTCCGGGGGGTCCGCGTCCACGGTGAAAACCCCGGGGCGCAGGCGCGCGTCGA 
               
               
                   
               
               
                 AGTAGTCTATCTTGCAACCTTGCATGTCCAGCGCCTGCTGCCAGTCGCGGGCGGCGAGCGCGCGCTC 
               
               
                   
               
               
                 GTAGGGGTTGAGCGGCGGGCCCCAGGGCATGGGGTGGGTGAGTGCGGAGGCGTACATGCCGCAGAT 
               
               
                   
               
               
                 GTCATAGACGTAGAGGGGCTCCCGCAGGACCCCGATGTAGGTGGGGTAGCAGCGGCCGCCGCGGAT 
               
               
                   
               
               
                 GCTGGCGCGCACGTAGTCATACAGCTCGTGCGAGGGGGCGAGGAGGTCGGGGCCCAGGTTGGTGCG 
               
               
                   
               
               
                 GGCGGGGCGCTCCGCGCGGAAGACGATCTGCCTGAAGATGGCATGCGAGTTGGAAGAGATGGTGGG 
               
               
                   
               
               
                 GCGCTGGAAGACGTTGAAGCTGGCGTCCTGCAGGCCGACGGCGTCGCGCACGAAGGAGGCGTAGGA 
               
               
                   
               
               
                 GTCGCGCAGCTTGTGTACCAGCTCGGCGGTGACCTGCACGTCGAGCGCGCAGTAGTCGAGGGTCTCG 
               
               
                   
               
               
                 CGGATGATGTCATATTTAGCCTGCCCCTTCTTTTTCCACAGCTCGCGGTTGAGGACAAACTCTTCGCG 
               
               
                   
               
               
                 GTCTTTCCAGTACTCTTGGATCGGGAAACCGTCCGGTTCCGAACGGTAAGAGCCTAGCATGTAGAAC 
               
               
                   
               
               
                 TGGTTGACGGCCTGGTAGGCGCAGCAGCCCTTCTCCACGGGGAGGGCGTAGGCCTGCGCGGCCTTGC 
               
               
                   
               
               
                 GGAGCGAGGTGTGGGTCAGGGCGAAGGTGTCCCTGACCATGACTTTGAGGTACTGGTGCTTGAAGTC 
               
               
                   
               
               
                 GGAGTCGTCGCAGCCGCCCCGCTCCCAGAGCGAGAAGTCGGTGCGCTTCTTGGAGCGGGGGTTGGGC 
               
               
                   
               
               
                 AGAGCGAAGGTGACATCGTTGAAGAGGATTTTGCCCGCGCGGGGCATGAAGTTGCGGGTGATGCGG 
               
               
                   
               
               
                 AAGGGCCCCGGCACTTCAGAGCGGTTGTTGATGACCTGGGCGGCGAGCACGATCTCGTCGAAGCCGT 
               
               
                   
               
               
                 TGATGTTGTGGCCCACGATGTAGAGTTCCAGGAAGCGGGGCCGGCCCTTTACGGTGGGCAGCTTCTT 
               
               
                   
               
               
                 TAGCTCTTCGTAGGTGAGCTCCTCGGGCGAGGCGAGGCCGTGCTCGGCCAGGGCCCAGTCCGCGAGG 
               
               
                   
               
               
                 TGCGGGTTGTCTCTGAGGAAGGACTTCCAGAGGTCGCGGGCCAGGAGGGTCTGCAGGCGGTCTCTGA 
               
               
                   
               
               
                 AGGTCCTGAACTGGCGGCCCACGGCCATTTTTTCGGGGGTGATGCAGTAGAAGGTGAGGGGGTCTTG 
               
               
                   
               
               
                 CTGCCAGCGGTCCCAGTCGAGCTGCAGGGCGAGGTCGCGCGCGGCGGTGACCAGGCGCTCGTCGCCC 
               
               
                   
               
               
                 CCGAATTTCATGACCAGCATGAAGGGCACGAGCTGCTTTCCGAAGGCCCCCATCCAAGTGTAGGTCT 
               
               
                   
               
               
                 CTACATCGTAGGTGACAAAGAGGCGCTCCGTGCGAGGATGCGAGCCGATCGGGAAGAACTGGATCT 
               
               
                   
               
               
                 CCCGCCACCAGTTGGAGGAGTGGCTGTTGATGTGGTGGAAGTAGAAGTCCCGTCGCCGGGCCGAACA 
               
               
                   
               
               
                 CTCGTGCTGGCTTTTGTAAAAGCGAGCGCAGTACTGGCAGCGCTGCACGGGCTGTACCTCATGCACG 
               
               
                   
               
               
                 AGATGCACCTTTCGCCCGCGCACGAGGAAGCCGAGGGGAAATCTGAGCCCCCCGCCTGGCTCGCGGC 
               
               
                   
               
               
                 ATGGCTGGTTCTCTTCTACTTTGGATGCGTGTCCGTCTCCGTCTGGCTCCTCGAGGGGTGTTACGGTG 
               
               
                   
               
               
                 GAGCGGACCACCACGCCGCGCGAGCCGCAGGTCCAGATATCGGCGCGCGGCGGTCGGAGTTTGATG 
               
               
                   
               
               
                 ACGACATCGCGCAGCTGGGAGCTGTCCATGGTCTGGAGCTCCCGCGGCGGCGGCAGGTCAGCCGGG 
               
               
                   
               
               
                 AGTTCTTGCAGGTTCACCTCGCAGAGTCGGGCCAGGGCGCGGGGCAGGTCTAGGTGGTACCTGATCT 
               
               
                   
               
               
                 CTAGGGGCGTGTTGGTGGCGGCGTCGATGGCTTGCAGGAGCCCGCAGCCCCGGGGGGCGACGACGG 
               
               
                   
               
               
                 TGCCCCGCGGGGTGGTGGTGGTGGTGGCGGTGCAGCTCAGAAGCGGTGCCGCGGGCGGGCCCCCGG 
               
               
                   
               
               
                 AGGTAGGGGGGGCTCCGGTCCCGCGGGCAGGGGCGGCAGCGGCACGTCGGCGTGGAGCGCGGGCAG 
               
               
                   
               
               
                 GAGTTGGTGCTGTGCCCGGAGGTTGCTGGCGAAGGCGACGACGCGGCGGTTGATCTCCTGGATCTGG 
               
               
                   
               
               
                 CGCCTCTGCGTGAAGACGACGGGCCCGGTGAGCTTGAACCTGAAAGAGAGTTCGACAGAATCAATCT 
               
               
                   
               
               
                 CGGTGTCATTGACCGCGGCCTGGCGCAGGATCTCCTGCACGTCTCCCGAGTTGTCTTGGTAGGCGATC 
               
               
                   
               
               
                 TCGGCCATGAACTGCTCGATCTCTTCCTCCTGGAGGTCTCCGCGTCCGGCGCGTTCCACGGTGGCCGC 
               
               
                   
               
               
                 CAGGTCGTTGGAGATGCGCCCCATGAGCTGCGAGAAGGCGTTGAGTCCGCCCTCGTTCCAGACTCGG 
               
               
                   
               
               
                 CTGTAGACCACGCCCCCCTGGTCATCGCGGGCGCGCATGACCACCTGCGCGAGGTTGAGCTCCACGT 
               
               
                   
               
               
                 GCCGCGCGAAGACGGCGTAGTTGCGCAGACGCTGGAAGAGGTAGTTGAGGGTGGTGGCGGTGTGCT 
               
               
                   
               
               
                 CGGCCACGAAGAAGTTCATGACCCAGCGGCGCAACGTGGATTCGTTGATGTCCCCCAAGGCCTCCAG 
               
               
                   
               
               
                 CCGTTCCATGGCCTCGTAGAAGTCCACGGCGAAGTTGAAAAACTGGGAGTTGCGCGCCGACACGGTC 
               
               
                   
               
               
                 AACTCCTCCTCCAGAAGACGGATGAGCTCGGCGACGGTGTCGCGCACCTCGCGCTCGAAGGCTATGG 
               
               
                   
               
               
                 GGATCTCTTCCTCCGCTAGCATCACCACCTCCTCCTCTTCCTCCTCTTCTGGCACTTCCATGATGGCTT 
               
               
                   
               
               
                 CCTCCTCTTCGGGGGGTGGCGGCGGCGGCGGTGGGGGAGGGGGCGCTCTGCGCCGGCGGCGGCGCA 
               
               
                   
               
               
                 CCGGGAGGCGGTCCACGAAGCGCGCGATCATCTCCCCGCGGCGGCGGCGCATGGTCTCGGTGACGGC 
               
               
                   
               
               
                 GCGGCCGTTCTCCCGGGGGCGCAGTTGGAAGACGCCGCCGGACATCTGGTGCTGGGGCGGGTGGCCG 
               
               
                   
               
               
                 TGAGGCAGCGAGACGGCGCTGACGATGCATCTCAACAATTGCTGCGTAGGTACGCCGCCGAGGGAC 
               
               
                   
               
               
                 CTGAGGGAGTCCATATCCACCGGATCCGAAAACCTTTCGAGGAAGGCGTCTAACCAGTCGCAGTCGC 
               
               
                   
               
               
                 AAGGTAGGCTGAGCACCGTGGCGGGCGGCGGGGGGTGGGGGGAGTGTCTGGCGGAGGTGCTGCTGA 
               
               
                   
               
               
                 TGATGTAATTGAAGTAGGCGGACTTGACACGGCGGATGGTCGACAGGAGCACCATGTCCTTGGGTCC 
               
               
                   
               
               
                 GGCCTGCTGGATGCGGAGGCGGTCGGCTATGCCCCAGGCTTCGTTCTGGCATCGGCGCAGGTCCTTG 
               
               
                   
               
               
                 TAGTAGTCTTGCATGAGCCTTTCCACCGGCACCTCTTCTCCTTCCTCTTCTGCTTCTTCCATGTCTGCTT 
               
               
                   
               
               
                 CGGCCCTGGGGCGGCGCCGCGCCCCCCTGCCCCCCATGCGCGTGACCCCGAACCCCCTGAGCGGTTG 
               
               
                   
               
               
                 GAGCAGGGCCAGGTCGGCGACGACGCGCTCGGCCAGGATGGCCTGCTGCACCTGCGTGAGGGTGGT 
               
               
                   
               
               
                 TTGGAAGTCATCCAAGTCCACGAAGCGGTGGTAGGCGCCCGTGTTGATGGTGTAGGTGCAGTTGGCC 
               
               
                   
               
               
                 ATGACGGACCAGTTGACGGTCTGGTGGCCCGGTTGCGACATCTCGGTGTACCTGAGTCGCGAGTAGG 
               
               
                   
               
               
                 CGCGGGAGTCGAAGACGTAGTCGTTGCAAGTCCGCACCAGGTACTGGTAGCCCACCAGGAAGTGCG 
               
               
                   
               
               
                 GCGGCGGCTGGCGGTAGAGGGGCCAGCGCAGGGTGGCGGGGGCTCCGGGGGCCAGGTCTTCCAGCA 
               
               
                   
               
               
                 TGAGGCGGTGGTAGGCGTAGATGTACCTGGACATCCAGGTGATACCCGCGGCGGTGGTGGAGGCGC 
               
               
                   
               
               
                 GCGGGAAGTCGCGCACCCGGTTCCAGATGTTGCGCAGGGGCAGAAAGTGCTCCATGGTAGGCGTGCT 
               
               
                   
               
               
                 CTGTCCAGTCAGACGCGCGCAGTCGTTGATACTCTAGACCAGGGAAAACGAAAGCCGGTCAGCGGG 
               
               
                   
               
               
                 CACTCTTCCGTGGTCTGGTGAATAGATCGCAAGGGTATCATGGCGGAGGGCCTCGGTTCGAGCCCCG 
               
               
                   
               
               
                 GGTCCGGGCCGGACGGTCCGCCATGATCCACGCGGTTACCGCCCGCGTGTCGAACCCAGGTGTGCGA 
               
               
                   
               
               
                 CGTCAGACAACGGTGGAGTGTTCCTTTTGGCGTTTTTCTGGCCGGGCGCCGGCGCCGCGTAAGAGAC 
               
               
                   
               
               
                 TAAGCCGCGAAAGCGAAAGCAGTAAGTGGCTCGCTCCCCGTAGCCGGAGGGATCCTTGCTAAGGGTT 
               
               
                   
               
               
                 GCGTTGCGGCGAACCCCGGTTCGAATCCCGTACTCGGGCCGGCCGGACCCGCGGCTAAGGTGTTGGA 
               
               
                   
               
               
                 TTGGCCTCCCCCTCGTATAAAGACCCCGCTTGCGGATTGACTCCGGACACGGGGACGAGCCCCTTTTA 
               
               
                   
               
               
                 TTTTTGCTTTCCCCAGATGCATCCGGTGCTGCGGCAGATGCGCCCCCCGCCCCAGCAGCAGCAACAAC 
               
               
                   
               
               
                 ACCAGCAAGAGCGGCAGCAACAGCAGCGGGAGTCATGCAGGGCCCCCTCACCCACCCTCGGCGGGC 
               
               
                   
               
               
                 CGGCCACCTCGGCGTCCGCGGCCGTGTCTGGCGCCTGCGGCGGCGGCGGGGGGCCGGCTGACGACCC 
               
               
                   
               
               
                 CGAGGAGCCCCCGCGGCGCAGGGCCAGACACTACCTGGACCTGGAGGAGGGCGAGGGCCTGGCGCG 
               
               
                   
               
               
                 GCTGGGGGCGCCGTCTCCCGAGCGCCACCCGCGGGTGCAGCTGAAGCGCGACTCGCGCGAGGCGTA 
               
               
                   
               
               
                 CGTGCCTCGGCAGAACCTGTTCAGGGACCGCGCGGGCGAGGAGCCCGAGGAGATGCGGGACAGGAG 
               
               
                   
               
               
                 GTTCAGCGCAGGGCGGGAGCTGCGGCAGGGGCTGAACCGCGAGCGGCTGCTGCGCGAGGAGGACTT 
               
               
                   
               
               
                 TGAGCCCGACGCGCGGACGGGGATCAGCCCCGCGCGCGCGCACGTGGCGGCCGCCGACCTGGTGAC 
               
               
                   
               
               
                 GGCGTACGAGCAGACGGTGAACCAGGAGATCAACTTCCAAAAGAGTTTCAACAACCACGTGCGCAC 
               
               
                   
               
               
                 GCTGGTGGCGCGCGAGGAGGTGACCATCGGGCTGATGCACCTGTGGGACTTTGTAAGCGCGCTGGTG 
               
               
                   
               
               
                 CAGAACCCCAACAGCAAGCCTCTGACGGCGCAGCTGTTCCTGATAGTGCAGCACAGCAGGGACAAC 
               
               
                   
               
               
                 GAGGCGTTTAGGGACGCGCTGCTGAACATCACCGAGCCCGAGGGTCGGTGGCTGCTGGACCTGATTA 
               
               
                   
               
               
                 ACATCCTGCAGAGCATAGTGGTGCAGGAGCGCAGCCTGAGCCTGGCCGACAAGGTGGCGGCCATCA 
               
               
                   
               
               
                 ACTACTCGATGCTGAGCCTGGGCAAGTTTTACGCGCGCAAGATCTACCAGACGCCGTACGTGCCCAT 
               
               
                   
               
               
                 AGACAAGGAGGTGAAGATCGACGGTTTTTACATGCGCATGGCGCTGAAGGTGCTCACCCTGAGCGAC 
               
               
                   
               
               
                 GACCTGGGCGTGTACCGCAACGAGCGCATCCACAAGGCCGTGAGCGTGAGCCGGCGGCGCGAGCTG 
               
               
                   
               
               
                 AGCGACCGCGAGCTGATGCACAGCCTGCAGCGGGCGCTGGCGGGCGCCGGCAGCGGCGACAGGGAG 
               
               
                   
               
               
                 GCGGAGTCCTACTTCGATGCGGGGGCGGACCTGCGCTGGGCGCCCAGCCGGCGGGCCCTGGAGGCC 
               
               
                   
               
               
                 GCGGGGGTCCGCGAGGACTATGACGAGGACGGCGAGGAGGATGAGGAGTACGAGCTAGAGGAGGG 
               
               
                   
               
               
                 CGAGTACCTGGACTAAACCGCGGGTGGTGTTTCCGGTAGATGCAAGACCCGAACGTGGTGGACCCGG 
               
               
                   
               
               
                 CGCTGCGGGCGGCTCTGCAGAGCCAGCCGTCCGGCCTTAACTCCTCAGACGACTGGCGACAGGTCAT 
               
               
                   
               
               
                 GGACCGCATCATGTCGCTGACGGCGCGTAACCCGGACGCGTTCCGGCAGCAGCCGCAGGCCAACAG 
               
               
                   
               
               
                 GCTCTCCGCCATCCTGGAGGCGGTGGTGCCTGCGCGCTCGAACCCCACGCACGAGAAGGTGCTGGCC 
               
               
                   
               
               
                 ATAGTGAACGCGCTGGCCGAGAACAGGGCCATCCGCCCGGACGAGGCCGGGCTGGTGTACGACGCG 
               
               
                   
               
               
                 CTGCTGCAGCGCGTGGCCCGCTACAACAGCGGCAACGTGCAGACCAACCTGGACCGGCTGGTGGGG 
               
               
                   
               
               
                 GACGTGCGCGAGGCGGTGGCGCAGCGCGAGCGCGCGGATCGGCAGGGCAACCTGGGCTCCATGGTG 
               
               
                   
               
               
                 GCGCTGAATGCCTTCCTGAGCACGCAGCCGGCCAACGTGCCGCGGGGGCAGGAAGACTACACCAAC 
               
               
                   
               
               
                 TTTGTGAGCGCGCTGCGGCTGATGGTGACCGAGACCCCCCAGAGCGAGGTGTACCAGTCGGGCCCGG 
               
               
                   
               
               
                 ACTACTTCTTCCAGACCAGCAGACAGGGCCTGCAGACGGTGAACCTGAGCCAGGCTTTCAAGAACCT 
               
               
                   
               
               
                 GCGGGGGCTGTGGGGCGTGAAGGCGCCCACCGGCGACCGGGCGACGGTGTCCAGCCTGCTGACGCC 
               
               
                   
               
               
                 CAACTCGCGCCTGCTGCTGCTGCTGATCGCGCCGTTCACGGACAGCGGCAGCGTGTCCCGGGACACC 
               
               
                   
               
               
                 TACCTGGGGCACCTGCTGACCCTGTACCGCGAGGCCATCGGGCAGGCGCAGGTGGACGAGCACACCT 
               
               
                   
               
               
                 TCCAGGAGATCACCAGCGTGAGCCGCGCGCTGGGGCAGGAGGACACGAGCAGCCTGGAGGCGACTC 
               
               
                   
               
               
                 TGAACTACCTGCTGACCAACCGGCGGCAGAAGATTCCCTCGCTGCACAGCCTGACCTCCGAGGAGGA 
               
               
                   
               
               
                 GCGCATCTTGCGCTACGTGCAGCAGAGCGTGAGCCTGAACCTGATGCGCGACGGGGTGACGCCCAGC 
               
               
                   
               
               
                 GTGGCGCTGGACATGACCGCGCGCAACATGGAACCGGGCATGTACGCCGCGCACCGGCCTTACATCA 
               
               
                   
               
               
                 ACCGCCTGATGGACTACCTGCATCGCGCGGCGGCCGTGAACCCCGAGTACTTTACCAACGCCATCCT 
               
               
                   
               
               
                 GAACCCGCACTGGCTCCCGCCGCCCGGGTTCTACAGCGGGGGCTTCGAGGTCCCGGAGACCAACGAT 
               
               
                   
               
               
                 GGCTTCCTGTGGGACGACATGGACGACAGCGTGTTCTCCCCGCGGCCGCAGGCGCTGGCGGAAGCGT 
               
               
                   
               
               
                 CCCTGCTGCGTCCCAAGAAGGAGGAGGAGGAGGAGGCGAGTCGCCGCCGCGGCAGCAGCGGCGTGG 
               
               
                   
               
               
                 CTTCTCTGTCCGAGCTGGGGGCGGCAGCCGCCGCGCGCCCCGGGTCCCTGGGCGGCAGCCCCTTTCC 
               
               
                   
               
               
                 GAGCCTGGTGGGGTCTCTGCACAGCGAGCGCACCACCCGCCCTCGGCTGCTGGGCGAGGACGAGTAC 
               
               
                   
               
               
                 CTGAATAACTCCCTGCTGCAGCCGGTGCGGGAGAAAAACCTGCCTCCCGCCTTCCCCAACAACGGGA 
               
               
                   
               
               
                 TAGAGAGCCTGGTGGACAAGATGAGCAGATGGAAGACCTATGCGCAGGAGCACAGGGACGCGCCTG 
               
               
                   
               
               
                 CGCTCCGGCCGCCCACGCGGCGCCAGCGCCACGACCGGCAGCGGGGGCTGGTGTGGGATGACGAGG 
               
               
                   
               
               
                 ACTCCGCGGACGATAGCAGCGTGCTGGACCTGGGAGGGAGCGGCAACCCGTTCGCGCACCTGCGCCC 
               
               
                   
               
               
                 CCGCCTGGGGAGGATGTTTTAAAAAAAAAAAAAAAAAGCAAGAAGCATGATGCAAAAATTAAATAA 
               
               
                   
               
               
                 AACTCACCAAGGCCATGGCGACCGAGCGTTGGTTTCTTGTGTTCCCTTCAGTATGCGGCGCGCGGCG 
               
               
                   
               
               
                 ATGTACCAGGAGGGACCTCCTCCCTCTTACGAGAGCGTGGTGGGCGCGGCGGCGGCGGCGCCCTCTT 
               
               
                   
               
               
                 CTCCCTTTGCGTCGCAGCTGCTGGAGCCGCCGTACGTGCCTCCGCGCTACCTGCGGCCTACGGGGGG 
               
               
                   
               
               
                 GAGAAACAGCATCCGTTACTCGGAGCTGGCGCCCCTGTTCGACACCACCCGGGTGTACCTGGTGGAC 
               
               
                   
               
               
                 AACAAGTCGGCGGACGTGGCCTCCCTGAACTACCAGAACGACCACAGCAATTTTTTGACCACGGTCA 
               
               
                   
               
               
                 TCCAGAACAATGACTACAGCCCGAGCGAGGCCAGCACCCAGACCATCAATCTGGATGACCGGTCGC 
               
               
                   
               
               
                 ACTGGGGCGGCGACCTGAAAACCATCCTGCACACCAACATGCCCAACGTGAACGAGTTCATGTTCAC 
               
               
                   
               
               
                 CAATAAGTTCAAGGCGCGGGTGATGGTGTCGCGCTCGCACACCAAGGAAGACCGGGTGGAGCTGAA 
               
               
                   
               
               
                 GTACGAGTGGGTGGAGTTCGAGCTGCCAGAGGGCAACTACTCCGAGACCATGACCATTGACCTGATG 
               
               
                   
               
               
                 AACAACGCGATCGTGGAGCACTATCTGAAAGTGGGCAGGCAGAACGGGGTCCTGGAGAGCGACATC 
               
               
                   
               
               
                 GGGGTCAAGTTCGACACCAGGAACTTCCGCCTGGGGCTGGACCCCGTGACCGGGCTGGTTATGCCCG 
               
               
                   
               
               
                 GGGTGTACACCAACGAGGCCTTCCATCCCGACATCATCCTGCTGCCCGGCTGCGGGGTGGACTTCAC 
               
               
                   
               
               
                 TTACAGCCGCCTGAGCAACCTCCTGGGCATCCGCAAGCGGCAGCCCTTCCAGGAGGGCTTCAGGATC 
               
               
                   
               
               
                 ACCTACGAGGACCTGGAGGGGGGCAACATCCCCGCGCTCCTCGATGTGGAGGCCTACCAGGATAGCT 
               
               
                   
               
               
                 TGAAGGAAAATGAGGCGGGACAGGAGGATACCGCCCCCGCCGCCTCCGCCGCCGCCGAGCAGGGCG 
               
               
                   
               
               
                 AGGATGCTGCTGACACCGCGGCCGCGGACGGGGCAGAGGCCGACCCCGCTATGGTGGTGGAGGCTC 
               
               
                   
               
               
                 CCGAGCAGGAGGAGGACATGAATGACAGTGCGGTGCGCGGAGACACCTTCGTCACCCGGGGGGAGG 
               
               
                   
               
               
                 AAAAGCAAGCGGAGGCCGAGGCCGCGGCCGAGGAAAAGCAACTGGCGGCAGCAGCGGCGGCGGCG 
               
               
                   
               
               
                 GCGTTGGCCGCGGCGGAGGCTGAGTCTGAGGGGACCAAGCCCGCCAAGGAGCCCGTGATTAAGCCC 
               
               
                   
               
               
                 CTGACCGAAGATAGCAAGAAGCGCAGTTACAACCTGCTCAAGGACAGCACCAACACCGCGTACCGC 
               
               
                   
               
               
                 AGCTGGTACCTGGCCTACAACTACGGCGACCCGTCGACGGGGGTGCGCTCCTGGACCCTGCTGTGCA 
               
               
                   
               
               
                 CGCCGGACGTGACCTGCGGCTCGGAGCAGGTGTACTGGTCGCTGCCCGACATGATGCAAGACCCCGT 
               
               
                   
               
               
                 GACCTTCCGCTCCACGCGGCAGGTCAGCAACTTCCCGGTGGTGGGCGCCGAGCTGCTGCCCGTGCAC 
               
               
                   
               
               
                 TCCAAGAGCTTCTACAACGACCAGGCCGTCTACTCCCAGCTCATCCGCCAGTTCACCTCTCTGACCCA 
               
               
                   
               
               
                 CGTGTTCAATCGCTTTCCTGAGAACCAGATTCTGGCGCGCCCGCCCGCCCCCACCATCACCACCGTCA 
               
               
                   
               
               
                 GTGAAAACGTTCCTGCTCTCACAGATCACGGGACGCTACCGCTGCGCAACAGCATCGGAGGAGTCCA 
               
               
                   
               
               
                 GCGAGTGACCGTTACTGACGCCAGACGCCGCACCTGCCCCTACGTTTACAAGGCCTTGGGCATAGTC 
               
               
                   
               
               
                 TCGCCGCGCGTCCTTTCCAGCCGCACTTTTTGAGCAACACCACCATCATGTCCATCCTGATCTCACCC 
               
               
                   
               
               
                 AGCAATAACTCCGGCTGGGGACTGCTGCGCGCGCCCAGCAAGATGTTCGGAGGGGCGAGGAAGCGT 
               
               
                   
               
               
                 TCCGAGCAGCACCCCGTGCGCGTGCGCGGGCACTTCCGCGCCCCCTGGGGAGCGCACAAACGCGGCC 
               
               
                   
               
               
                 GCGCGGGGCGCACCACCGTGGACGACGCCATCGACTCGGTGGTGGAGCAGGCGCGCAACTACAGGC 
               
               
                   
               
               
                 CCGCGGTCTCTACCGTGGACGCGGCCATCCAGACCGTGGTGCGGGGCGCGCGGCGGTACGCCAAGCT 
               
               
                   
               
               
                 GAAGAGCCGCCGGAAGCGCGTGGCCCGCCGCCACCGCCGCCGACCCGGGGCCGCCGCCAAACGCGC 
               
               
                   
               
               
                 CGCCGCGGCCCTGCTTCGCCGGGCCAAGCGCACGGGCCGCCGCGCCGCCATGAGGGCCGCGCGCCGC 
               
               
                   
               
               
                 TTGGCCGCCGGCATCACCGCCGCCACCATGGCCCCCCGTACCCGAAGACGCGCGGCCGCCGCCGCCG 
               
               
                   
               
               
                 CCGCCGCCATCAGTGACATGGCCAGCAGGCGCCGGGGCAACGTGTACTGGGTGCGCGACTCGGTGAC 
               
               
                   
               
               
                 CGGCACGCGCGTGCCCGTGCGCTTCCGCCCCCCGCGGACTTGAGATGATGTGAAAAAACAACACTGA 
               
               
                   
               
               
                 GTCTCCTGCTGTTGTGTGTATCCCAGCGGCGGCGGCGCGCGCAGCGTCATGTCCAAGCGCAAAATCA 
               
               
                   
               
               
                 AAGAAGAGATGCTCCAGGTCGTCGCGCCGGAGATCTATGGGCCCCCGAAGAAGGAAGAGCAGGATT 
               
               
                   
               
               
                 CGAAGCCCCGCAAGATAAAGCGGGTCAAAAAGAAAAAGAAAGATGATGACGATGCCGATGGGGAG 
               
               
                   
               
               
                 GTGGAGTTCCTGCGCGCCACGGCGCCCAGGCGCCCGGTGCAGTGGAAGGGCCGGCGCGTAAAGCGC 
               
               
                   
               
               
                 GTCCTGCGCCCCGGCACCGCGGTGGTCTTCACGCCCGGCGAGCGCTCCACCCGGACTTTCAAGCGCG 
               
               
                   
               
               
                 TCTATGACGAGGTGTACGGCGACGAAGACCTGCTGGAGCAGGCCAACGAGCGCTTCGGAGAGTTTGC 
               
               
                   
               
               
                 TTACGGGAAGCGTCAGCGGGCGCTGGGGAAGGAGGACCTGCTGGCGCTGCCGCTGGACCAGGGCAA 
               
               
                   
               
               
                 CCCCACCCCCAGTCTGAAGCCCGTGACCCTGCAGCAGGTGCTGCCGAGCAGCGCACCCTCCGAGGCG 
               
               
                   
               
               
                 AAGCGGGGTCTGAAGCGCGAGGGCGGCGACCTGGCGCCCACCGTGCAGCTCATGGTGCCCAAGCGG 
               
               
                   
               
               
                 CAGAGGCTGGAGGATGTGCTGGAGAAAATGAAAGTAGACCCCGGTCTGCAGCCGGACATCAGGGTC 
               
               
                   
               
               
                 CGCCCCATCAAGCAGGTGGCGCCGGGCCTCGGCGTGCAGACCGTGGACGTGGTCATCCCCACCGGCA 
               
               
                   
               
               
                 ACTCCCCCGCCGCCGCCACCACTACCGCTGCCTCCACGGACATGGAGACACAGACCGATCCCGCCGC 
               
               
                   
               
               
                 AGCCGCAGCCGCAGCCGCCGCCGCGACCTCCTCGGCGGAGGTGCAGACGGACCCCTGGCTGCCGCCG 
               
               
                   
               
               
                 GCGATGTCAGCTCCCCGCGCGCGTCGCGGGCGCAGGAAGTACGGCGCCGCCAACGCGCTCCTGCCCG 
               
               
                   
               
               
                 AGTACGCCTTGCATCCTTCCATCGCGCCCACCCCCGGCTACCGAGGCTATACCTACCGCCCGCGAAG 
               
               
                   
               
               
                 AGCCAAGGGTTCCACCCGCCGTCCCCGCCGACGCGCCGCCGCCACCACCCGCCGCCGCCGCCGCAGA 
               
               
                   
               
               
                 CGCCAGCCCGCACTGGCTCCAGTCTCCGTGAGGAAAGTGGCGCGCGACGGACACACCCTGGTGCTGC 
               
               
                   
               
               
                 CCAGGGCGCGCTACCACCCCAGCATCGTTTAAAAGCCTGTTGTGGTTCTTGCAGATATGGCCCTCACT 
               
               
                   
               
               
                 TGCCGCCTCCGTTTCCCGGTGCCGGGATACCGAGGAGGAAGATCGCGCCGCAGGAGGGGTCTGGCCG 
               
               
                   
               
               
                 GCCGCGGCCTGAGCGGAGGCAGCCGCCGCGCGCACCGGCGGCGACGCGCCACCAGCCGACGCATGC 
               
               
                   
               
               
                 GCGGCGGGGTGCTGCCCCTGTTAATCCCCCTGATCGCCGCGGCGATCGGCGCCGTGCCCGGGATCGC 
               
               
                   
               
               
                 CTCCGTGGCCTTGCAAGCGTCCCAGAGGCATTGACAGACTTGCAAACTTGCAAATATGGAAAAAAAA 
               
               
                   
               
               
                 ACCCCAATAAAAAAGTCTAGACTCTCACGCTCGCTTGGTCCTGTGACTATTTTGTAGAATGGAAGAC 
               
               
                   
               
               
                 ATCAACTTTGCGTCGCTGGCCCCGCGTCACGGCTCGCGCCCGTTCCTGGGACACTGGAACGATATCG 
               
               
                   
               
               
                 GCACCAGCAACATGAGCGGTGGCGCCTTCAGTTGGGGCTCTCTGTGGAGCGGCATTAAAAGTATCGG 
               
               
                   
               
               
                 GTCTGCCGTTAAAAATTACGGCTCCCGGGCCTGGAACAGCAGCACGGGCCAGATGTTGAGAGACAA 
               
               
                   
               
               
                 GTTGAAAGAGCAGAACTTCCAGCAGAAGGTGGTGGAGGGCCTGGCCTCCGGCATCAACGGGGTGGT 
               
               
                   
               
               
                 GGACCTGGCCAACCAGGCCGTGCAGAATAAGATCAACAGCAGACTGGACCCCCGGCCGCCGGTGGA 
               
               
                   
               
               
                 GGAGGTGCCGCCGGCGCTGGAGACGGTGTCCCCCGATGGGCGTGGCGAGAAGCGCCCGCGGCCCGA 
               
               
                   
               
               
                 TAGGGAAGAGACCACTCTGGTCACGCAGACCGATGAGCCGCCCCCGTATGAGGAGGCCCTGAAGCA 
               
               
                   
               
               
                 AGGTCTGCCCACCACGCGGCCCATCGCGCCCATGGCCACCGGGGTGGTGGGCCGCCACACCCCCGCC 
               
               
                   
               
               
                 ACGCTGGACTTGCCTCCGCCCGCCGATGTGCCGCAGCAGCAGAAGGCGGCACAGCCGGGCCCGCCCG 
               
               
                   
               
               
                 CGACCGCCTCCCGTTCCTCCGCCGGTCCTCTGCGCCGCGCGGCCAGCGGCCCCCGCGGGGGGGTCGC 
               
               
                   
               
               
                 GAGGCACGGCAACTGGCAGAGCACGCTGAACAGCATCGTGGGTCTGGGGGTGCGGTCCGTGAAGCG 
               
               
                   
               
               
                 CCGCCGATGCTACTGAATAGCTTAGCTAACGTGTTGTATGTGTGTATGCGCCCTATGTCGCCGCCAGA 
               
               
                   
               
               
                 GGAGCTGCTGAGTCGCCGCCGTTCGCGCGCCCACCACCACCGCCACTCCGCCCCTCAAGATGGCGAC 
               
               
                   
               
               
                 CCCATCGATGATGCCGCAGTGGTCGTACATGCACATCTCGGGCCAGGACGCCTCGGAGTACCTGAGC 
               
               
                   
               
               
                 CCCGGGCTGGTGCAGTTCGCCCGCGCCACCGAGAGCTACTTCAGCCTGAGTAACAAGTTTAGGAACC 
               
               
                   
               
               
                 CCACGGTGGCGCCCACGCACGATGTGACCACCGACCGGTCTCAGCGCCTGACGCTGCGGTTCATTCC 
               
               
                   
               
               
                 CGTGGACCGCGAGGACACCGCGTACTCGTACAAGGCGCGGTTCACCCTGGCCGTGGGCGACAACCGC 
               
               
                   
               
               
                 GTGCTGGACATGGCCTCCACCTACTTTGACATCCGCGGGGTGCTGGACCGGGGTCCCACTTTCAAGCC 
               
               
                   
               
               
                 CTACTCTGGCACCGCCTACAACTCCCTGGCCCCCAAGGGCGCTCCCAACTCCTGCGAGTGGGAGCAA 
               
               
                   
               
               
                 GAGGAAACTCAGGCAGTTGAAGAAGCAGCAGAAGAGGAAGAAGAAGATGCTGACGGTCAAGCTGA 
               
               
                   
               
               
                 GGAAGAGCAAGCAGCTACCAAAAAGACTCATGTATATGCTCAGGCTCCCCTTTCTGGCGAAAAAATT 
               
               
                   
               
               
                 AGTAAAGATGGTCTGCAAATAGGAACGGACGCTACAGCTACAGAACAAAAACCTATTTATGCAGAC 
               
               
                   
               
               
                 CCTACATTCCAGCCCGAACCCCAAATCGGGGAGTCCCAGTGGAATGAGGCAGATGCTACAGTCGCCG 
               
               
                   
               
               
                 GCGGTAGAGTGCTAAAGAAATCTACTCCCATGAAACCATGCTATGGTTCCTATGCAAGACCCACAAA 
               
               
                   
               
               
                 TGCTAATGGAGGTCAGGGTGTACTAACGGCAAATGCCCAGGGACAGCTAGAATCTCAGGTTGAAATG 
               
               
                   
               
               
                 CAATTCTTTTCAACTTCTGAAAACGCCCGTAACGAGGCTAACAACATTCAGCCCAAATTGGTGCTGTA 
               
               
                   
               
               
                 TAGTGAGGATGTGCACATGGAGACCCCGGATACGCACCTTTCTTACAAGCCCGCAAAAAGCGATGAC 
               
               
                   
               
               
                 AATTCAAAAATCATGCTGGGTCAGCAGTCCATGCCCAACAGACCTAATTACATCGGCTTCAGAGACA 
               
               
                   
               
               
                 ACTTTATCGGCCTCATGTATTACAATAGCACTGGCAACATGGGAGTGCTTGCAGGTCAGGCCTCTCAG 
               
               
                   
               
               
                 TTGAATGCAGTGGTGGACTTGCAAGACAGAAACACAGAACTGTCCTACCAGCTCTTGCTTGATTCCA 
               
               
                   
               
               
                 TGGGTGACAGAACCAGATACTTTTCCATGTGGAATCAGGCAGTGGACAGTTATGACCCAGATGTTAG 
               
               
                   
               
               
                 AATTATTGAAAATCATGGAACTGAAGACGAGCTCCCCAACTATTGTTTCCCTCTGGGTGGCATAGGG 
               
               
                   
               
               
                 GTAACTGACACTTACCAGGCTGTTAAAACCAACAATGGCAATAACGGGGGCCAGGTGACTTGGACA 
               
               
                   
               
               
                 AAAGATGAAACTTTTGCAGATCGCAATGAAATAGGGGTGGGAAACAATTTCGCTATGGAGATCAACC 
               
               
                   
               
               
                 TCAGTGCCAACCTGTGGAGAAACTTCCTGTACTCCAACGTGGCGCTGTACCTACCAGACAAGCTTAA 
               
               
                   
               
               
                 GTACAACCCCTCCAATGTGGACATCTCTGACAACCCCAACACCTACGATTACATGAACAAGCGAGTG 
               
               
                   
               
               
                 GTGGCCCCGGGGCTGGTGGACTGCTACATCAACCTGGGCGCGCGCTGGTCGCTGGACTACATGGACA 
               
               
                   
               
               
                 ACGTCAACCCCTTCAACCACCACCGCAATGCGGGCCTGCGCTACCGCTCCATGCTCCTGGGCAACGG 
               
               
                   
               
               
                 GCGCTACGTGCCCTTCCACATCCAGGTGCCCCAGAAGTTCTTTGCCATCAAGAACCTCCTCCTCCTGC 
               
               
                   
               
               
                 CGGGCTCCTACACCTACGAGTGGAACTTCAGGAAGGATGTCAACATGGTCCTCCAGAGCTCTCTGGG 
               
               
                   
               
               
                 TAACGATCTCAGGGTGGACGGGGCCAGCATCAAGTTCGAGAGCATCTGCCTCTACGCCACCTTCTTC 
               
               
                   
               
               
                 CCCATGGCCCACAACACGGCCTCCACGCTCGAGGCCATGCTCAGGAACGACACCAACGACCAGTCCT 
               
               
                   
               
               
                 TCAATGACTACCTCTCCGCCGCCAACATGCTCTACCCCATACCCGCCAACGCCACCAACGTCCCCATC 
               
               
                   
               
               
                 TCCATCCCCTCGCGCAACTGGGCGGCCTTCCGCGGCTGGGCCTTCACCCGCCTCAAGACCAAGGAGA 
               
               
                   
               
               
                 CCCCCTCCCTGGGCTCGGGATTCGACCCCTACTACACCTACTCGGGCTCCATTCCCTACCTGGACGGC 
               
               
                   
               
               
                 ACCTTCTACCTCAACCACACTTTCAAGAAGGTCTCGGTCACCTTCGACTCCTCGGTCAGCTGGCCGGG 
               
               
                   
               
               
                 CAACGACCGTCTGCTCACCCCCAACGAGTTCGAGATCAAGCGCTCGGTCGACGGGGAGGGCTACAAC 
               
               
                   
               
               
                 GTGGCCCAGTGCAACATGACCAAGGACTGGTTCCTGGTCCAGATGCTGGCCAACTACAACATCGGCT 
               
               
                   
               
               
                 ACCAGGGCTTCTACATCCCAGAGAGCTACAAGGACAGGATGTACTCCTTCTTCAGGAACTTCCAGCC 
               
               
                   
               
               
                 CATGAGCCGGCAGGTGGTGGACCAGACCAAGTACAAGGACTACCAGGAGGTGGGCATCATCCACCA 
               
               
                   
               
               
                 GCACAACAACTCGGGCTTCGTGGGCTACCTCGCCCCCACCATGCGCGAGGGACAGGCCTACCCCGCC 
               
               
                   
               
               
                 AACTTCCCCTATCCGCTCATAGGCAAGACCGCGGTCGACAGCATCACCCAGAAAAAGTTCCTCTGCG 
               
               
                   
               
               
                 ACCGCACCCTCTGGCGCATCCCCTTCTCCAGCAACTTCATGTCCATGGGTGCGCTCTCGGACCTGGGC 
               
               
                   
               
               
                 CAGAACTTGCTCTACGCCAACTCCGCCCACGCCCTCGACATGACCTTCGAGGTCGACCCCATGGACG 
               
               
                   
               
               
                 AGCCCACCCTTCTCTATGTTCTGTTCGAAGTCTTTGACGTGGTCCGGGTCCACCAGCCGCACCGCGGC 
               
               
                   
               
               
                 GTCATCGAGACCGTGTACCTGCGTACGCCCTTCTCGGCCGGCAACGCCACCACCTAAAGAAGCAAGC 
               
               
                   
               
               
                 CGCAGTCATCGCCGCCTGCATGCCGTCGGGTTCCACCGAGCAAGAGCTCAGGGCCATCGTCAGAGAC 
               
               
                   
               
               
                 CTGGGATGCGGGCCCTATTTTTTGGGCACCTTCGACAAGCGCTTCCCTGGCTTTGTCTCCCCACACAA 
               
               
                   
               
               
                 GCTGGCCTGCGCCATCGTCAACACGGCCGGCCGCGAGACCGGGGGCGTGCACTGGCTGGCCTTCGCC 
               
               
                   
               
               
                 TGGAACCCGCGCTCCAAAACATGCTTCCTCTTTGACCCCTTCGGCTTTTCGGACCAGCGGCTCAAGCA 
               
               
                   
               
               
                 AATCTACGAGTTCGAGTACGAGGGCTTGCTGCGTCGCAGCGCCATCGCCTCCTCGCCCGACCGCTGC 
               
               
                   
               
               
                 GTCACCCTCGAAAAGTCCACCCAGACCGTGCAGGGGCCCGACTCGGCCGCCTGCGGTCTCTTCTGCT 
               
               
                   
               
               
                 GCATGTTTCTGCACGCCTTTGTGCACTGGCCTCAGAGTCCCATGGACCGCAACCCCACCATGAACTTG 
               
               
                   
               
               
                 CTGACGGGGGTGCCCAACTCCATGCTCCAGAGCCCCCAGGTCGAGCCCACCCTGCGCCGCAACCAGG 
               
               
                   
               
               
                 AGCAGCTCTACAGCTTCCTGGAGCGCCACTCGCCTTACTTCCGCCGCCACAGCGCACAGATCAGGAG 
               
               
                   
               
               
                 GGCCACCTCCTTCTGCCACTTGCAAGAGATGCAAGAAGGGTAATAACGATGTACACACTTTTTTTCTC 
               
               
                   
               
               
                 AATAAATGGCATCTTTTTATTTATACAAGCTCTCTGGGGTATTCATTTCCCACCACCACCCGCCGTTGT 
               
               
                   
               
               
                 CGCCATCTGGCTCTATTTAGAAATCGAAAGGGTTCTGCCGGGAGTCGCCGTGCGCCACGGGCAGGGA 
               
               
                   
               
               
                 CACGTTGCGATACTGGTAGCGGGTGCCCCACTTGAACTCGGGCACCACCAGGCGAGGCAGCTCGGGG 
               
               
                   
               
               
                 AAGTTTTCGCTCCACAGGCTGCGGGTCAGCACCAGCGCGTTCATCAGGTCGGGCGCCGAGATCTTGA 
               
               
                   
               
               
                 AGTCGCAGTTGGGGCCGCCGCCCTGCGCGCGCGAGTTGCGGTACACCGGGTTGCAGCACTGGAACAC 
               
               
                   
               
               
                 CAACAGCGCCGGGTGCTTCACGCTGGCCAGCACGCTGCGGTCGGAGATCAGCTCGGCGTCCAGGTCC 
               
               
                   
               
               
                 TCCGCGTTGCTCAGCGCGAACGGGGTCATCTTGGGCACTTGCCGCCCCAGGAAGGGCGCGTGCCCCG 
               
               
                   
               
               
                 GTTTCGAGTTGCAGTCGCAGCGCAGCGGGATCAGCAGGTGCCCGTGCCCGGACTCGGCGTTGGGGTA 
               
               
                   
               
               
                 CAGCGCGCGCATGAAGGCCTGCATCTGGCGGAAGGCCATCTGGGCCTTGGCGCCCTCCGAGAAGAAC 
               
               
                   
               
               
                 ATGCCGCAGGACTTGCCCGAGAACTGGTTTGCGGGGCAGCTGGCGTCGTGCAGGCAGCAGCGCGCGT 
               
               
                   
               
               
                 CGGTGTTGGCGATCTGCACCACGTTGCGCCCCCACCGGTTCTTCACGATCTTGGCCTTGGACGATTGC 
               
               
                   
               
               
                 TCCTTCAGCGCGCGCTGCCCGTTCTCGCTGGTCACATCCATCTCGATCACATGTTCCTTGTTCACCATG 
               
               
                   
               
               
                 CTGCTGCCGTGCAGACACTTCAGCTCGCCCTCCGTCTCGGTGCAGCGGTGCTGCCACAGCGCGCAGC 
               
               
                   
               
               
                 CCGTGGGCTCGAAAGACTTGTAGGTCACCTCCGCGAAGGACTGCAGGTACCCCTGCAAAAAGCGGCC 
               
               
                   
               
               
                 CATCATGGTCACGAAGGTCTTGTTGCTGCTGAAGGTCAGCTGCAGCCCGCGGTGCTCCTCGTTCAGCC 
               
               
                   
               
               
                 AGGTCTTGCACACGGCCGCCAGCGCCTCCACCTGGTCGGGCAGCATCTTGAAGTTCACCTTCAGCTCA 
               
               
                   
               
               
                 TTCTCCACGTGGTACTTGTCCATCAGCGTGCGCGCCGCCTCCATGCCCTTCTCCCAGGCCGACACCAG 
               
               
                   
               
               
                 CGGCAGGCTCACGGGGTTCTTCACCATCACCGTGGCCGCCGCCTCCGCCGCGCTTTCGCTTTCCGCCC 
               
               
                   
               
               
                 CGCTGTTCTCTTCCTCTTCCTCCTCTTCCTCGCCGCCGCCCACTCGCAGCCCCCGCACCACGGGGTCGT 
               
               
                   
               
               
                 CTTCCTGCAGGCGCTGCACCTTGCGCTTGCCGTTGCGCCCCTGCTTGATGCGCACGGGCGGGTTGCTG 
               
               
                   
               
               
                 AAGCCCACCATCACCAGCGCGGCCTCTTCTTGCTCGTCCTCGCTGTCCAGAATGACCTCCGGGGAGG 
               
               
                   
               
               
                 GGGGGTTGGTCATCCTCAGTACCGAGGCACGCTTCTTTTTCTTCCTGGGGGCGTTCGCCAGCTCCGCG 
               
               
                   
               
               
                 GCTGCGGCCGCTGCCGAGGTCGAAGGCCGAGGGCTGGGCGTGCGCGGCACCAGCGCGTCCTGCGAG 
               
               
                   
               
               
                 CCGTCCTCGTCCTCCTCGGACTCGAGACGGAGGCGGGCCCGCTTCTTCGGGGGCGCGCGGGGCGGCG 
               
               
                   
               
               
                 GAGGCGGCGGCGGCGACGGAGACGGGGACGAGACATCGTCCAGGGTGGGTGGACGGCGGGCCGCG 
               
               
                   
               
               
                 CCGCGTCCGCGCTCGGGGGTGGTCTCGCGCTGGTCCTCTTCCCGACTGGCCATCTCCCACTGCTCCTT 
               
               
                   
               
               
                 CTCCTATAGGCAGAAAGAGATCATGGAGTCTCTCATGCGAGTCGAGAAGGAGGAGGACAGCCTAAC 
               
               
                   
               
               
                 CGCCCCCTCTGAGCCCTCCACCACCGCCGCCACCACCGCCAATGCCGCCGCGGACGACGCGCCCACC 
               
               
                   
               
               
                 GAGACCACCGCCAGTACCACCCTCCCCAGCGACGCACCCCCGCTCGAGAATGAAGTGCTGATCGAGC 
               
               
                   
               
               
                 AGGACCCGGGTTTTGTGAGCGGAGAGGAGGATGAGGTGGATGAGAAGGAGAAGGAGGAGGTCGCC 
               
               
                   
               
               
                 GCCTCAGTGCCAAAAGAGGATAAAAAGCAAGACCAGGACGACGCAGATAAGGATGAGACAGCAGT 
               
               
                   
               
               
                 CGGGCGGGGGAACGGAAGCCATGATGCTGATGACGGCTACCTAGACGTGGGAGACGACGTGCTGCT 
               
               
                   
               
               
                 TAAGCACCTGCACCGCCAGTGCGTCATCGTCTGCGACGCGCTGCAGGAGCGCTGCGAAGTGCCCCTG 
               
               
                   
               
               
                 GACGTGGCGGAGGTCAGCCGCGCCTACGAGCGGCACCTCTTCGCGCCGCACGTGCCCCCCAAGCGCC 
               
               
                   
               
               
                 GGGAGAACGGCACCTGCGAGCCCAACCCGCGTCTCAACTTCTACCCGGTCTTCGCGGTACCCGAGGT 
               
               
                   
               
               
                 GCTGGCCACCTACCACATCTTTTTCCAAAACTGCAAGATCCCCCTCTCCTGCCGCGCCAACCGCACCC 
               
               
                   
               
               
                 GCGCCGACAAAACCCTGACCCTGCGGCAGGGCGCCCACATACCTGATATCGCCTCTCTGGAGGAAGT 
               
               
                   
               
               
                 GCCCAAGATCTTCGAGGGTCTCGGTCGCGACGAGAAACGGGCGGCGAACGCTCTGCACGGAGACAG 
               
               
                   
               
               
                 CGAAAACGAGAGTCACTCGGGGGTGCTGGTGGAGCTCGAGGGCGACAACGCGCGCCTGGCCGTACT 
               
               
                   
               
               
                 CAAGCGCAGCATAGAGGTCACCCACTTTGCCTACCCGGCGCTCAACCTGCCCCCCAAGGTCATGAGT 
               
               
                   
               
               
                 GTGGTCATGGGCGAGCTCATCATGCGCCGCGCCCAGCCCCTGGCCGCGGATGCAAACTTGCAAGAGT 
               
               
                   
               
               
                 CCTCCGAGGAAGGCCTGCCCGCGGTCAGCGACGAGCAGCTGGCGCGCTGGCTGGAGACCCGCGACC 
               
               
                   
               
               
                 CCGCGCAGCTGGAGGAGCGGCGCAAGCTCATGATGGCCGCGGTGCTGGTCACCGTGGAGCTCGAGT 
               
               
                   
               
               
                 GTCTGCAGCGCTTCTTCGCGGACCCCGAGATGCAGCGCAAGCTCGAGGAGACCCTGCACTACACCTT 
               
               
                   
               
               
                 CCGCCAGGGCTACGTGCGCCAGGCCTGCAAGATCTCCAACGTGGAGCTCTGCAACCTGGTCTCCTAC 
               
               
                   
               
               
                 CTGGGCATCCTGCACGAGAACCGCCTCGGGCAGAACGTCCTGCACTCCACCCTCAAAGGGGAGGCGC 
               
               
                   
               
               
                 GCCGCGACTACATCCGCGACTGCGCCTACCTCTTCCTCTGCTACACCTGGCAGACGGCCATGGGGGTC 
               
               
                   
               
               
                 TGGCAGCAGTGCCTGGAGGAGCGCAACCTCAAGGAGCTGGAAAAGCTCCTCAAGCGCACCCTCAGG 
               
               
                   
               
               
                 GACCTCTGGACGGGCTTCAACGAGCGCTCGGTGGCCGCCGCGCTGGCGGACATCATCTTTCCCGAGC 
               
               
                   
               
               
                 GCCTGCTCAAGACCCTGCAGCAGGGCCTGCCCGACTTCACCAGCCAGAGCATGCTGCAGAACTTCAG 
               
               
                   
               
               
                 GACTTTCATCCTGGAGCGCTCGGGCATCCTGCCGGCCACTTGCTGCGCGCTGCCCAGCGACTTCGTGC 
               
               
                   
               
               
                 CCATCAAGTACAGGGAGTGCCCGCCGCCGCTCTGGGGCCACTGCTACCTCTTCCAGCTGGCCAACTA 
               
               
                   
               
               
                 CCTCGCCTACCACTCGGACCTCATGGAAGACGTGAGCGGCGAGGGCCTGCTCGAGTGCCACTGCCGC 
               
               
                   
               
               
                 TGCAACCTCTGCACGCCCCACCGCTCTCTAGTCTGCAACCCGCAGCTGCTCAGCGAGAGTCAGATTAT 
               
               
                   
               
               
                 CGGTACCTTCGAGCTGCAGGGTCCCTCGCCTGACGAGAAGTCCGCGGCTCCAGGGCTGAAACTCACT 
               
               
                   
               
               
                 CCGGGGCTGTGGACTTCCGCCTACCTACGCAAATTTGTACCTGAGGACTACCACGCCCACGAGATCA 
               
               
                   
               
               
                 GGTTCTACGAAGACCAATCCCGCCCGCCCAAGGCGGAGCTCACCGCCTGCGTCATCACCCAGGGGCA 
               
               
                   
               
               
                 CATCCTGGGCCAATTGCAAGCCATCAACAAAGCCCGCCGAGAGTTCTTGCTGAAAAAGGGTCGGGGG 
               
               
                   
               
               
                 GTGTACCTGGACCCCCAGTCCGGCGAGGAGCTAAACCCGCTACCCCCGCCGCCGCCCCAGCAGCGGG 
               
               
                   
               
               
                 ACCTTGCTTCCCAGGATGGCACCCAGAAAGAAGCAGCAGCCGCCGCCGCCGCCGCAGCCATACATGC 
               
               
                   
               
               
                 TTCTGGAGGAAGAGGAGGAGGACTGGGACAGTCAGGCAGAGGAGGTTTCGGACGAGGAGCAGGAG 
               
               
                   
               
               
                 GAGATGATGGAAGACTGGGAGGAGGACAGCAGCCTAGACGAGGAAGCTTCAGAGGCCGAAGAGGT 
               
               
                   
               
               
                 GGCAGACGCAACACCATCGCCCTCGGTCGCAGCCCCCTCGCCGGGGCCCCTGAAATCCTCCGAACCC 
               
               
                   
               
               
                 AGCACCAGCGCTATAACCTCCGCTCCTCCGGCGCCGGCGCCACCCGCCCGCAGACCCAACCGTAGAT 
               
               
                   
               
               
                 GGGACACCACAGGAACCGGGGTCGGTAAGTCCAAGTGCCCGCCGCCGCCACCGCAGCAGCAGCAGC 
               
               
                   
               
               
                 AGCAGCGCCAGGGCTACCGCTCGTGGCGCGGGCACAAGAACGCCATAGTCGCCTGCTTGCAAGACTG 
               
               
                   
               
               
                 CGGGGGCAACATCTCTTTCGCCCGCCGCTTCCTGCTATTCCACCACGGGGTCGCCTTTCCCCGCAATG 
               
               
                   
               
               
                 TCCTGCATTACTACCGTCATCTCTACAGCCCCTACTGCAGCGGCGACCCAGAGGCGGCAGCGGCAGC 
               
               
                   
               
               
                 CACAGCGGCGACCACCACCTAGGAAGATATCCTCCGCGGGCAAGACAGCGGCAGCAGCGGCCAGGA 
               
               
                   
               
               
                 GACCCGCGGCAGCAGCGGCGGGAGCGGTGGGCGCACTGCGCCTCTCGCCCAACGAACCCCTCTCGAC 
               
               
                   
               
               
                 CCGGGAGCTCAGACACAGGATCTTCCCCACTTTGTATGCCATCTTCCAACAGAGCAGAGGCCAGGAG 
               
               
                   
               
               
                 CAGGAGCTGAAAATAAAAAACAGATCTCTGCGCTCCCTCACCCGCAGCTGTCTGTATCACAAAAGCG 
               
               
                   
               
               
                 AAGATCAGCTTCGGCGCACGCTGGAGGACGCGGAGGCACTCTTCAGCAAATACTGCGCGCTCACTCT 
               
               
                   
               
               
                 TAAAGACTAGCTCCGCGCCCTTCTCGAATTTAGGCGGGAGAAAACTACGTCATCGCCGGCCGCCGCC 
               
               
                   
               
               
                 CAGCCCGCCCAGCCGAGATGAGCAAAGAGATTCCCACGCCATACATGTGGAGCTACCAGCCGCAGA 
               
               
                   
               
               
                 TGGGACTCGCGGCGGGAGCGGCCCAGGACTACTCCACCCGCATGAACTACATGAGCGCGGGACCCC 
               
               
                   
               
               
                 ACATGATCTCACAGGTCAACGGGATCCGCGCCCAGCGAAACCAAATACTGCTGGAACAGGCGGCCA 
               
               
                   
               
               
                 TCACCGCCACGCCCCGCCATAATCTCAACCCCCGAAATTGGCCCGCCGCCCTCGTGTACCAGGAAAC 
               
               
                   
               
               
                 CCCCTCCGCCACCACCGTACTACTTCCGCGTGACGCCCAGGCCGAAGTCCAGATGACTAACTCAGGG 
               
               
                   
               
               
                 GCGCAGCTCGCGGGCGGCTTTCGTCACGGGGCGCGGCCGCTCCGACCAGGTATAAGACACCTGATGA 
               
               
                   
               
               
                 TCAGAGGCCGAGGTATCCAGCTCAACGACGAGTCGGTGAGCTCTTCGCTCGGTCTCCGTCCGGACGG 
               
               
                   
               
               
                 AACTTTCCAGCTCGCCGGATCCGGCCGCTCTTCGTTCACGCCCCGCCAGGCGTACCTGACTCTGCAGA 
               
               
                   
               
               
                 CCTCGTCCTCGGAGCCCCGCTCCGGCGGCATCGGAACCCTCCAGTTCGTGGAGGAGTTCGTGCCCTCG 
               
               
                   
               
               
                 GTCTACTTCAACCCCTTCTCGGGACCTCCCGGACGCTACCCCGACCAGTTCATTCCGAACTTTGACGC 
               
               
                   
               
               
                 GGTGAAGGACTCGGCGGACGGCTACGACTGAATGTCAGGTGTCGAGGCAGAGCAGCTTCGCCTGAG 
               
               
                   
               
               
                 ACACCTCGAGCACTGCCGCCGCCACAAGTGCTTCGCCCGCGGTTCTGGTGAGTTCTGCTACTTTCAGC 
               
               
                   
               
               
                 TACCCGAGGAGCATACCGAGGGGCCGGCGCACGGCGTCCGCCTGACCACCCAGGGCGAGGTTACCT 
               
               
                   
               
               
                 GTTCCCTCATCCGGGAGTTTACCCTCCGTCCCCTGCTAGTGGAGCGGGAGCGGGGTCCCTGTGTCCTA 
               
               
                   
               
               
                 ACTATCGCCTGCAACTGCCCTAACCCTGGATTACATCAAGATCTTTGCTGTCATCTCTGTGCTGAGTTT 
               
               
                   
               
               
                 AATAAACGCTGAGATCAGAATCTACTGGGGCTCCTGTCGCCATCCTGTGAACGCCACCGTCTTCACCC 
               
               
                   
               
               
                 ACCCCGACCAGGCCCAGGCGAACCTCACCTGCGGTCTGCATCGGAGGGCCAAGAAGTACCTCACCTG 
               
               
                   
               
               
                 GTACTTCAACGGCACCCCCTTTGTGGTTTACAACAGCTTCGACGGGGACGGAGTCTCCCTGAAAGAC 
               
               
                   
               
               
                 CAGCTCTCCGGTCTCAGCTACTCCATCCACAAGAACACCACCCTCCAACTCTTCCCTCCCTACCTGCC 
               
               
                   
               
               
                 GGGAACCTACGAGTGCGTCACCGGCCGCTGCACCCACCTCACCCGCCTGATCGTAAACCAGAGCTTT 
               
               
                   
               
               
                 CCGGGAACAGATAACTCCCTCTTCCCCAGAACAGGAGGTGAGCTCAGGAAACTCCCCGGGGACCAG 
               
               
                   
               
               
                 GGCGGAGACGTACCTTCGACCCTTGTGGGGTTAGGATTTTTTATTACCGGGTTGCTGGCTCTTTTAAT 
               
               
                   
               
               
                 CAAAGTTTCCTTGAGATTTGTTCTTTCCTTCTACGTGTATGAACACCTCAACCTCCAATAACTCTACCC 
               
               
                   
               
               
                 TTTCTTCGGAATCAGGTGACTTCTCTGAAATCGGGCTTGGTGTGCTGCTTACTCTGTTGATTTTTTTCC 
               
               
                   
               
               
                 TTATCATACTCAGCCTTCTGTGCCTCAGGCTCGCCGCCTGCTGCGCACACATCTATATCTACTGCTGGT 
               
               
                   
               
               
                 TGCTCAAGTGCAGGGGTCGCCACCCAAGATGAACAGGTACATGGTCCTATCGATCCTAGGCCTGCTG 
               
               
                   
               
               
                 GCCCTGGCGGCCTGCAGCGCCGCCAAAAAAGAGATTACCTTTGAGGAGCCCGCTTGCAATGTAACTT 
               
               
                   
               
               
                 TCAAGCCCGAGGGTGACCAATGCACCACCCTCGTCAAATGCGTTACCAATCATGAGAGGCTGCGCAT 
               
               
                   
               
               
                 CGACTACAAAAACAAAACTGGCCAGTTTGCGGTCTATAGTGTGTTTACGCCCGGAGACCCCTCTAAC 
               
               
                   
               
               
                 TACTCTGTCACCGTCTTCCAGGGCGGACAGTCTAAGATATTCAATTACACTTTCCCTTTTTATGAGTTA 
               
               
                   
               
               
                 TGCGATGCGGTCATGTACATGTCAAAACAGTACAACCTGTGGCCTCCCTCTCCCCAGGCGTGTGTGG 
               
               
                   
               
               
                 AAAATACTGGGTCTTACTGCTGTATGGCTTTCGCAATCACTACGCTCGCTCTAATCTGCACGGTGCTA 
               
               
                   
               
               
                 TACATAAAATTCAGGCAGAGGCGAATCTTTATCGATGAAAAGAAAATGCCTTGATCGCTAACACCGG 
               
               
                   
               
               
                 CTTTCTATCTGCAGAATGAATGCAATCACCTCCCTACTAATCACCACCACCCTCCTTGCGATTGCCCA 
               
               
                   
               
               
                 TGGGTTGACACGAATCGAAGTGCCAGTGGGGTCCAATGTCACCATGGTGGGCCCCGCCGGCAATTCC 
               
               
                   
               
               
                 ACCCTCATGTGGGAAAAATTTGTCCGCAATCAATGGGTTCATTTCTGCTCTAACCGAATCAGTATCAA 
               
               
                   
               
               
                 GCCCAGAGCCATCTGCGATGGGCAAAATCTAACTCTGATCAATGTGCAAATGATGGATGCTGGGTAC 
               
               
                   
               
               
                 TATTACGGGCAGCGGGGAGAAATCATTAATTACTGGCGACCCCACAAGGACTACATGCTGCATGTAG 
               
               
                   
               
               
                 TCGAGGCACTTCCCACTACCACCCCCACTACCACCTCTCCCACCACCACCACCACTACTACTACTACT 
               
               
                   
               
               
                 ACTACTACTACTACTACTACCACTACCGCTGCCCGCCATACCCGCAAAAGCACCATGATTAGCACAA 
               
               
                   
               
               
                 AGCCCCCTCGTGCTCACTCCCACGCCGGCGGGCCCATCGGTGCGACCTCAGAAACCACCGAGCTTTG 
               
               
                   
               
               
                 CTTCTGCCAATGCACTAACGCCAGCGCTCATGAACTGTTCGACCTGGAGAATGAGGATGTCCAGCAG 
               
               
                   
               
               
                 AGCTCCGCTTGCCTGACCCAGGAGGCTGTGGAGCCCGTTGCCCTGAAGCAGATCGGTGATTCAATAA 
               
               
                   
               
               
                 TTGACTCTTCTTCTTTTGCCACTCCCGAATACCCTCCCGATTCTACTTTCCACATCACGGGTACCAAAG 
               
               
                   
               
               
                 ACCCTAACCTCTCTTTCTACCTGATGCTGCTGCTCTGTATCTCTGTGGTCTCTTCCGCGCTGATGTTAC 
               
               
                   
               
               
                 TGGGGATGTTCTGCTGCCTGATCTGCCGCAGAAAGAGAAAAGCTCGCTCTCAGGGCCAACCACTGAT 
               
               
                   
               
               
                 GCCCTTCCCCTACCCCCCGGATTTTGCAGATAACAAGATATGAGCTCGCTGCTGACACTAACCGCTTT 
               
               
                   
               
               
                 ACTAGCCTGCGCTCTAACCCTTGTCGCTTGCGACTCGAGATTCCACAATGTCACAGCTGTGGCAGGAG 
               
               
                   
               
               
                 AAAATGTTACTTTCAACTCCACGGCCGATACCCAGTGGTCGTGGAGTGGCTCAGGTAGCTACTTAACT 
               
               
                   
               
               
                 ATCTGCAATAGCTCCACTTCCCCCGGCATATCCCCAACCAAGTACCAATGCAATGCCAGCCTGTTCAC 
               
               
                   
               
               
                 CCTCATCAACGCTTCCACCCTGGACAATGGACTCTATGTAGGCTATGTACCCTTTGGTGGGCAAGGAA 
               
               
                   
               
               
                 AGACCCACGCTTACAACCTGGAAGTTCGCCAGCCCAGAACCACTACCCAAGCTTCTCCCACCACCAC 
               
               
                   
               
               
                 CACCACCACCACCATCACCAGCAGCAGCAGCAGCAGCAGCCACAGCAGCAGCAGCAGATTATTGAC 
               
               
                   
               
               
                 TTTGGTTTTGGCCAGCTCATCTGCCGCTACCCAGGCCATCTACAGCTCTGTGCCCGAAACCACTCAGA 
               
               
                   
               
               
                 TCCACCGCCCAGAAACGACCACCGCCACCACCCTACACACCTCCAGCGATCAGATGCCGACCAACAT 
               
               
                   
               
               
                 CACCCCCTTGGCTCTTCAAATGGGACTTACAAGCCCCACTCCAAAACCAGTGGATGCGGCCGAGGTC 
               
               
                   
               
               
                 TCCGCCCTCGTCAATGACTGGGCGGGGCTGGGAATGTGGTGGTTCGCCATAGGCATGATGGCGCTCT 
               
               
                   
               
               
                 GCCTGCTTCTGCTCTGGCTCATCTGCTGCCTCCACCGCAGGCGAGCCAGACCCCCCATCTATAGACCC 
               
               
                   
               
               
                 ATCATTGTCCTGAACCCCGATAATGATGGGATCCATAGATTGGATGGCCTGAAAAACCTACTTTTTTC 
               
               
                   
               
               
                 TTTTACAGTATGATAAATTGAGACATGCCTCGCATTTTCTTGTACATGTTCCTTCTCCCACCTTTTCTG 
               
               
                   
               
               
                 GGGTGTTCTACGCTGGCCGCTGTGTCTCACCTGGAGGTAGACTGCCTCTCACCCTTCACTGTCTACCT 
               
               
                   
               
               
                 GCTTTACGGATTGGTCACCCTCACTCTCATCTGCAGCCTAATCACAGTAATCATCGCCTTCATCCAGT 
               
               
                   
               
               
                 GCATTGATTACATCTGTGTGCGCCTCGCATACTTCAGACACCACCCGCAGTACCGAGACAGGAACAT 
               
               
                   
               
               
                 TGCCCAACTTCTAAGACTGCTCTAATCATGCATAAGACTGTGATCTGCCTTCTGATCCTCTGCATCCT 
               
               
                   
               
               
                 GCCCACCCTCACCTCCTGCCAGTACACCACAAAATCTCCGCGCAAAAGACATGCCTCCTGCCGCTTCA 
               
               
                   
               
               
                 CCCAACTGTGGAATATACCCAAATGCTACAACGAAAAGAGCGAGCTCTCCGAAGCTTGGCTGTATGG 
               
               
                   
               
               
                 GGTCATCTGTGTCTTAGTTTTCTGCAGCACTGTCTTTGCCCTCATAATCTACCCCTACTTTGATTTGGG 
               
               
                   
               
               
                 ATGGAACGCGATCGATGCCATGAATTACCCCACCTTTCCCGCACCCGAGATAATTCCACTGCGACAA 
               
               
                   
               
               
                 GTTGTACCCGTTGTCGTTAATCAACGCCCCCCATCCCCTACGCCCACTGAAATCAGCTACTTTAACCT 
               
               
                   
               
               
                 AACAGGCGGAGATGACTGACGCCCTAGATCTAGAAATGGACGGCATCAGTACCGAGCAGCGTCTCCT 
               
               
                   
               
               
                 AGAGAGGCGCAGGCAGGCGGCTGAGCAAGAGCGCCTCAATCAGGAGCTCCGAGATCTCGTTAACCT 
               
               
                   
               
               
                 GCACCAGTGCAAAAGAGGCATCTTTTGTCTGGTAAAGCAGGCCAAAGTCACCTACGAGAAGACCGG 
               
               
                   
               
               
                 CAACAGCCACCGCCTCAGTTACAAATTGCCCACCCAGCGCCAGAAGCTGGTGCTCATGGTGGGTGAG 
               
               
                   
               
               
                 AATCCCATCACCGTCACCCAGCACTCGGTAGAGACCGAGGGGTGTCTGCACTCCCCCTGTCGGGGTC 
               
               
                   
               
               
                 CAGAAGACCTCTGCACCCTGGTAAAGACCCTGTGCGGTCTCAGAGATTTAGTCCCCTTTAACTAATCA 
               
               
                   
               
               
                 AACACTGGAATCAATAAAAAGAATCACTTACTTAAAATCAGACAGCAGGTCTCTGTCCAGTTTATTC 
               
               
                   
               
               
                 AGCAGCACCTCCTTCCCCTCCTCCCAACTCTGGTACTCCAAACGCCTTCTGGCGGCAAACTTCCTCCA 
               
               
                   
               
               
                 CACCCTGAAGGGAATGTCAGATTCTTGCTCCTGTCCCTCCGCACCCACTATCTTCATGTTGTTGCAGA 
               
               
                   
               
               
                 TGAAGCGCACCAAAACGTCTGACGAGAGCTTCAACCCCGTGTACCCCTATGACACGGAAAGCGGCCC 
               
               
                   
               
               
                 TCCCTCCGTCCCTTTCCTCACCCCTCCCTTCGTGTCTCCCGATGGATTCCAAGAAAGTCCCCCCGGGGT 
               
               
                   
               
               
                 CCTGTCTCTGAACCTGGCCGAGCCCCTGGTCACTTCCCACGGCATGCTCGCCCTGAAAATGGGAAGT 
               
               
                   
               
               
                 GGCCTCTCCCTGGACGACGCTGGCAACCTCACCTCTCAAGATATCACCACCGCTAGCCCTCCCCTCAA 
               
               
                   
               
               
                 AAAAACCAAGACCAACCTCAGCCTAGAAACCTCATCCCCCCTAACTGTGAGCACCTCAGGCGCCCTC 
               
               
                   
               
               
                 ACCGTAGCAGCCGCCGCTCCCCTGGCGGTGGCCGGCACCTCCCTCACCATGCAATCAGAGGCCCCCC 
               
               
                   
               
               
                 TGACAGTACAGGATGCAAAACTCACCCTGGCCACCAAAGGCCCCCTGACCGTGTCTGAAGGCAAACT 
               
               
                   
               
               
                 GGCCTTGCAAACATCGGCCCCGCTGACGGCCGCTGACAGCAGCACCCTCACAGTCAGTGCCACACCA 
               
               
                   
               
               
                 CCCCTTAGCACAAGCAATGGCAGCTTGGGTATTGACATGCAAGCCCCCATTTACACCACCAATGGAA 
               
               
                   
               
               
                 AACTAGGACTTAACTTTGGCGCTCCCCTGCATGTGGTAGACAGCCTAAATGCACTGACTGTAGTTACT 
               
               
                   
               
               
                 GGCCAAGGTCTTACGATAAACGGAACAGCCCTACAAACTAGAGTCTCAGGTGCCCTCAACTATGACA 
               
               
                   
               
               
                 CATCAGGAAACCTAGAATTGAGAGCTGCAGGGGGTATGCGAGTTGATGCAAATGGTCAACTTATCCT 
               
               
                   
               
               
                 TGATGTAGCTTACCCATTTGATGCACAAAACAATCTCAGCCTTAGGCTTGGACAGGGACCCCTGTTTG 
               
               
                   
               
               
                 TTAACTCTGCCCACAACTTGGATGTTAACTACAACAGAGGCCTCTACCTGTTCACATCTGGAAATACC 
               
               
                   
               
               
                 AAAAAGCTAGAAGTTAATATCAAAACAGCCAAGGGTCTCATTTATGATGACACTGCTATAGCAATCA 
               
               
                   
               
               
                 ATGCGGGTGATGGGCTACAGTTTGACTCAGGCTCAGATACAAATCCATTAAAAACTAAACTTGGATT 
               
               
                   
               
               
                 AGGACTGGATTATGACTCCAGCAGAGCCATAATTGCTAAACTGGGAACTGGCCTAAGCTTTGACAAC 
               
               
                   
               
               
                 ACAGGTGCCATCACAGTAGGCAACAAAAATGATGACAAGCTTACCTTGTGGACCACACCAGACCCAT 
               
               
                   
               
               
                 CCCCTAACTGTAGAATCTATTCAGAGAAAGATGCTAAATTCACACTTGTTTTGACTAAATGCGGCAGT 
               
               
                   
               
               
                 CAGGTGTTGGCCAGCGTTTCTGTTTTATCTGTAAAAGGTAGCCTTGCGCCCATCAGTGGCACAGTAAC 
               
               
                   
               
               
                 TAGTGCTCAGATTGTCCTCAGATTTGATGAAAATGGAGTTCTACTAAGCAATTCTTCCCTTGACCCTC 
               
               
                   
               
               
                 AATACTGGAACTACAGAAAAGGTGACCTTACAGAGGGCACTGCATATACCAACGCAGTGGGATTTAT 
               
               
                   
               
               
                 GCCCAACCTCACAGCATACCCAAAAACACAGAGCCAAACTGCTAAAAGCAACATTGTAAGTCAGGTT 
               
               
                   
               
               
                 TACTTGAATGGGGACAAATCCAAACCCATGACCCTCACCATTACCCTCAATGGAACTAATGAAACAG 
               
               
                   
               
               
                 GAGATGCCACAGTAAGCACTTACTCCATGTCATTCTCATGGAACTGGAATGGAAGTAATTACATTAA 
               
               
                   
               
               
                 TGAAACGTTCCAAACCAACTCCTTCACCTTCTCCTACATCGCCCAAGAATAAAAAGCATGACGCTGTT 
               
               
                   
               
               
                 GATTTGATTCAATGTGTTTCTGTTTTATTTTCAAGCACAACAAAATCATTCAAGTCATTCTTCCATCTT 
               
               
                   
               
               
                 AGCTTAATAGACACAGTAGCTTAATAGACCCAGTAGTGCAAAGCCCCATTCTAGCTTATAACTAGTG 
               
               
                   
               
               
                 GAGAAGTACTCGCCTACATGGGGGTAGAGTCATAATCGTGCATCAGGATAGGGCGGTGGTGCTGCAG 
               
               
                   
               
               
                 CAGCGCGCGAATAAACTGCTGCCGCCGCCGCTCCGTCCTGCAGGAATACAACATGGCAGTGGTCTCC 
               
               
                   
               
               
                 TCAGCGATGATTCGCACCGCCCGCAGCATAAGGCGCCTTGTCCTCCGGGCACAGCAGCGCACCCTGA 
               
               
                   
               
               
                 TCTCACTTAAATCAGCACAGTAACTGCAGCACAGCACCACAATATTGTTCAAAATCCCACAGTGCAA 
               
               
                   
               
               
                 GGCGCTGTATCCAAAGCTCATGGCGGGGACCACAGAACCCACGTGGCCATCATACCACAAGCGCAG 
               
               
                   
               
               
                 GTAGATTAAGTGGCGACCCCTCATAAACACGCTGGACATAAACATTACCTCTTTTGGCATGTTGTAAT 
               
               
                   
               
               
                 TCACCACCTCCCGGTACCATATAAACCTCTGATTAAACATGGCGCCATCCACCACCATCCTAAACCAG 
               
               
                   
               
               
                 CTGGCCAAAACCTGCCCGCCGGCTATACACTGCAGGGAACCGGGACTGGAACAATGACAGTGGAGA 
               
               
                   
               
               
                 GCCCAGGACTCGTAACCATGGATCATCATGCTCGTCATGATATCAATGTTGGCACAACACAGGCACA 
               
               
                   
               
               
                 CGTGCATACACTTCCTCAGGATTACAAGCTCCTCCCGCGTTAGAACCATATCCCAGGGAACAACCCA 
               
               
                   
               
               
                 TTCCTGAATCAGCGTAAATCCCACACTGCAGGGAAGACCTCGCACGTAACTCACGTTGTGCATTGTC 
               
               
                   
               
               
                 AAAGTGTTACATTCGGGCAGCAGCGGATGATCCTCCAGTATGGTAGCGCGGGTTTCTGTCTCAAAAG 
               
               
                   
               
               
                 GAGGTAGACGATCCCTACTGTACGGAGTGCGCCGAGACAACCGAGATCGTGTTGGTCGTAGTGTCAT 
               
               
                   
               
               
                 GCCAAATGGAACGCCGGACGTAGTCATATTTCCTGAAGTCTTAGATCTCTCAACGCAGCACCAGCAC 
               
               
                   
               
               
                 CAACACTTCGCAGTGTAAAAGGCCAAGTGCCGAGAGAGTATATATAGGAATAAAAAGTGACGTAAA 
               
               
                   
               
               
                 CGGGCAAAGTCCAAAAAACGCCCAGAAAAACCGCACGCGAACCTACGCCCCGAAACGAAAGCCAAA 
               
               
                   
               
               
                 AAACACTAGACACTCCCTTCCGGCGTCAACTTCCGCTTTCCCACGCTACGTCACTTGCCCCAGTCAAA 
               
               
                   
               
               
                 CAAACTACATATCCCGAACTTCCAAGTCGCCACGCCCAAAACACCGCCTACACCTCCCCGCCCGCCG 
               
               
                   
               
               
                 GCCCGCCCCCAAACCCGCCTCCCGCCCCGCGCCCCGCCCCGCGCCGCCCATCTCATTATCATATTGGC 
               
               
                   
               
               
                 TTCAATCCAAAATAAGGTATATTATTGATGATGGTTTAAACGGATCCTCTAGAGTCGACCTGCAGGC 
               
               
                   
               
               
                 ATGCAAGCTTGAGTATTCTATAGTGTCACCTAAATAGCTTGGCGTAATCATGGTCATAGCTGTTTCCT 
               
               
                   
               
               
                 GTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCT 
               
               
                   
               
               
                 GGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGA 
               
               
                   
               
               
                 AACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGAACCCCTTGCGGCCGCCCGGGCCGTCG 
               
               
                   
               
               
                 ACCAATTCTCATGTTTGACAGCTTATCATCGAATTTCTGCCATTCATCCGCTTATTATCACTTATTCAG 
               
               
                   
               
               
                 GCGTAGCAACCAGGCGTTTAAGGGCACCAATAACTGCCTTAAAAAAATTACGCCCCGCCCTGCCACT 
               
               
                   
               
               
                 CATCGCAGTACTGTTGTAATTCATTAAGCATTCTGCCGACATGGAAGCCATCACAAACGGCATGATG 
               
               
                   
               
               
                 AACCTGAATCGCCAGCGGCATCAGCACCTTGTCGCCTTGCGTATAATATTTGCCCATGGTGAAAACG 
               
               
                   
               
               
                 GGGGCGAAGAAGTTGTCCATATTGGCCACGTTTAAATCAAAACTGGTGAAACTCACCCAGGGATTGG 
               
               
                   
               
               
                 CTGAGACGAAAAACATATTCTCAATAAACCCTTTAGGGAAATAGGCCAGGTTTTCACCGTAACACGC 
               
               
                   
               
               
                 CACATCTTGCGAATATATGTGTAGAAACTGCCGGAAATCGTCGTGGTATTCACTCCAGAGCGATGAA 
               
               
                   
               
               
                 AACGTTTCAGTTTGCTCATGGAAAACGGTGTAACAAGGGTGAACACTATCCCATATCACCAGCTCAC 
               
               
                   
               
               
                 CGTCTTTCATTGCCATACGGAATTCCGGATGAGCATTCATCAGGCGGGCAAGAATGTGAATAAAGGC 
               
               
                   
               
               
                 CGGATAAAACTTGTGCTTATTTTTCTTTACGGTCTTTAAAAAGGCCGTAATATCCAGCTGAACGGTCT 
               
               
                   
               
               
                 GGTTATAGGTACATTGAGCAACTGACTGAAATGCCTCAAAATGTTCTTTACGATGCCATTGGGATATA 
               
               
                   
               
               
                 TCAACGGTGGTATATCCAGTGATTTTTTTCTCCATTTTAGCTTCCTTAGCTCCTGAAAATCTCGATAAC 
               
               
                   
               
               
                 TCAAAAAATACGCCCGGTAGTGATCTTATTTCATTATGGTGAAAGTTGGAACCTCTTACGTGCCGATC 
               
               
                   
               
               
                 AACGTCTCATTTTCGCCAAAAGTTGGCCCAGGGCTTCCCGGTATCAACAGGGACACCAGGATTTATTT 
               
               
                   
               
               
                 ATTCTGCGAAGTGATCTTCCGTCACAGGTATTTATTCGCGATAAGCTCATGGAGCGGCGTAACCGTCG 
               
               
                   
               
               
                 CACAGGAAGGACAGAGAAAGCGCGGATCTGGGAAGTGACGGACAGAACGGTCAGGACCTGGATTG 
               
               
                   
               
               
                 GGGAGGCGGTTGCCGCCGCTGCTGCTGACGGTGTGACGTTCTCTGTTCCGGTCACACCACATACGTTC 
               
               
                   
               
               
                 CGCCATTCCTATGCGATGCACATGCTGTATGCCGGTATACCGCTGAAAGTTCTGCAAAGCCTGATGG 
               
               
                   
               
               
                 GACATAAGTCCATCAGTTCAACGGAAGTCTACACGAAGGTTTTTGCGCTGGATGTGGCTGCCCGGCA 
               
               
                   
               
               
                 CCGGGTGCAGTTTGCGATGCCGGAGTCTGATGCGGTTGCGATGCTGAAACAATTATCCTGAGAATAA 
               
               
                   
               
               
                 ATGCCTTGGCCTTTATATGGAAATGTGGAACTGAGTGGATATGCTGTTTTTGTCTGTTAAACAGAGAA 
               
               
                   
               
               
                 GCTGGCTGTTATCCACTGAGAAGCGAACGAAACAGTCGGGAAAATCTCCCATTATCGTAGAGATCCG 
               
               
                   
               
               
                 CATTATTAATCTCAGGAGCCTGTGTAGCGTTTATAGGAAGTAGTGTTCTGTCATGATGCCTGCAAGCG 
               
               
                   
               
               
                 GTAACGAAAACGATTTGAATATGCCTTCAGGAACAATAGAAATCTTCGTGCGGTGTTACGTTGAAGT 
               
               
                   
               
               
                 GGAGCGGATTATGTCAGCAATGGACAGAACAACCTAATGAACACAGAACCATGATGTGGTCTGTCCT 
               
               
                   
               
               
                 TTTACAGCCAGTAGTGCTCGCCGCAGTCGAGCGACAGGGCGAAGCCCTCGAGTGAGCGAGGAAGCA 
               
               
                   
               
               
                 CCAGGGAACAGCACTTATATATTCTGCTTACACACGATGCCTGAAAAAACTTCCCTTGGGGTTATCCA 
               
               
                   
               
               
                 CTTATCCACGGGGATATTTTTATAATTATTTTTTTTATAGTTTTTAGATCTTCTTTTTTAGAGCGCCTTG 
               
               
                   
               
               
                 TAGGCCTTTATCCATGCTGGTTCTAGAGAAGGTGTTGTGACAAATTGCCCTTTCAGTGTGACAAATCA 
               
               
                   
               
               
                 CCCTCAAATGACAGTCCTGTCTGTGACAAATTGCCCTTAACCCTGTGACAAATTGCCCTCAGAAGAA 
               
               
                   
               
               
                 GCTGTTTTTTCACAAAGTTATCCCTGCTTATTGACTCTTTTTTATTTAGTGTGACAATCTAAAAACTTG 
               
               
                   
               
               
                 TCACACTTCACATGGATCTGTCATGGCGGAAACAGCGGTTATCAATCACAAGAAACGTAAAAATAGC 
               
               
                   
               
               
                 CCGCGAATCGTCCAGTCAAACGACCTCACTGAGGCGGCATATAGTCTCTCCCGGGATCAAAAACGTA 
               
               
                   
               
               
                 TGCTGTATCTGTTCGTTGACCAGATCAGAAAATCTGATGGCACCCTACAGGAACATGACGGTATCTG 
               
               
                   
               
               
                 CGAGATCCATGTTGCTAAATATGCTGAAATATTCGGATTGACCTCTGCGGAAGCCAGTAAGGATATA 
               
               
                   
               
               
                 CGGCAGGCATTGAAGAGTTTCGCGGGGAAGGAAGTGGTTTTTTATCGCCCTGAAGAGGATGCCGGCG 
               
               
                   
               
               
                 ATGAAAAAGGCTATGAATCTTTTCCTTGGTTTATCAAACGTGCGCACAGTCCATCCAGAGGGCTTTAC 
               
               
                   
               
               
                 AGTGTACATATCAACCCATATCTCATTCCCTTCTTTATCGGGTTACAGAACCGGTTTACGCAGTTTCG 
               
               
                   
               
               
                 GCTTAGTGAAACAAAAGAAATCACCAATCCGTATGCCATGCGTTTATACGAATCCCTGTGTCAGTAT 
               
               
                   
               
               
                 CGTAAGCCGGATGGCTCAGGCATCGTCTCTCTGAAAATCGACTGGATCATAGAGCGTTACCAGCTGC 
               
               
                   
               
               
                 CTCAAAGTTACCAGCGTATGCCTGACTTCCGCCGCCGCTTCCTGCAGGTCTGTGTTAATGAGATCAAC 
               
               
                   
               
               
                 AGCAGAACTCCAATGCGCCTCTCATACATTGAGAAAAAGAAAGGCCGCCAGACGACTCATATCGTAT 
               
               
                   
               
               
                 TTTCCTTCCGCGATATCACTTCCATGACGACAGGATAGTCTGAGGGTTATCTGTCACAGATTTGAGGG 
               
               
                   
               
               
                 TGGTTCGTCACATTTGTTCTGACCTACTGAGGGTAATTTGTCACAGTTTTGCTGTTTCCTTCAGCCTGC 
               
               
                   
               
               
                 ATGGATTTTCTCATACTTTTTGAACTGTAATTTTTAAGGAAGCCAAATTTGAGGGCAGTTTGTCACAG 
               
               
                   
               
               
                 TTGATTTCCTTCTCTTTCCCTTCGTCATGTGACCTGATATCGGGGGTTAGTTCGTCATCATTGATGAGG 
               
               
                   
               
               
                 GTTGATTATCACAGTTTATTACTCTGAATTGGCTATCCGCGTGTGTACCTCTACCTGGAGTTTTTCCCA 
               
               
                   
               
               
                 CGGTGGATATTTCTTCTTGCGCTGAGCGTAAGAGCTATCTGACAGAACAGTTCTTCTTTGCTTCCTCG 
               
               
                   
               
               
                 CCAGTTCGCTCGCTATGCTCGGTTACACGGCTGCGGCGAGCGCTAGTGATAATAAGTGACTGAGGTA 
               
               
                   
               
               
                 TGTGCTCTTCTTATCTCCTTTTGTAGTGTTGCTCTTATTTTAAACAACTTTGCGGTTTTTTGATGACTTT 
               
               
                   
               
               
                 GCGATTTTGTTGTTGCTTTGCAGTAAATTGCAAGATTTAATAAAAAAACGCAAAGCAATGATTAAAG 
               
               
                   
               
               
                 GATGTTCAGAATGAAACTCATGGAAACACTTAACCAGTGCATAAACGCTGGTCATGAAATGACGAAG 
               
               
                   
               
               
                 GCTATCGCCATTGCACAGTTTAATGATGACAGCCCGGAAGCGAGGAAAATAACCCGGCGCTGGAGA 
               
               
                   
               
               
                 ATAGGTGAAGCAGCGGATTTAGTTGGGGTTTCTTCTCAGGCTATCAGAGATGCCGAGAAAGCAGGGC 
               
               
                   
               
               
                 GACTACCGCACCCGGATATGGAAATTCGAGGACGGGTTGAGCAACGTGTTGGTTATACAATTGAACA 
               
               
                   
               
               
                 AATTAATCATATGCGTGATGTGTTTGGTACGCGATTGCGACGTGCTGAAGACGTATTTCCACCGGTGA 
               
               
                   
               
               
                 TCGGGGTTGCTGCCCATAAAGGTGGCGTTTACAAAACCTCAGTTTCTGTTCATCTTGCTCAGGATCTG 
               
               
                   
               
               
                 GCTCTGAAGGGGCTACGTGTTTTGCTCGTGGAAGGTAACGACCCCCAGGGAACAGCCTCAATGTATC 
               
               
                   
               
               
                 ACGGATGGGTACCAGATCTTCATATTCATGCAGAAGACACTCTCCTGCCTTTCTATCTTGGGGAAAAG 
               
               
                   
               
               
                 GACGATGTCACTTATGCAATAAAGCCCACTTGCTGGCCGGGGCTTGACATTATTCCTTCCTGTCTGGC 
               
               
                   
               
               
                 TCTGCACCGTATTGAAACTGAGTTAATGGGCAAATTTGATGAAGGTAAACTGCCCACCGATCCACAC 
               
               
                   
               
               
                 CTGATGCTCCGACTGGCCATTGAAACTGTTGCTCATGACTATGATGTCATAGTTATTGACAGCGCGCC 
               
               
                   
               
               
                 TAACCTGGGTATCGGCACGATTAATGTCGTATGTGCTGCTGATGTGCTGATTGTTCCCACGCCTGCTG 
               
               
                   
               
               
                 AGTTGTTTGACTACACCTCCGCACTGCAGTTTTTCGATATGCTTCGTGATCTGCTCAAGAACGTTGAT 
               
               
                   
               
               
                 CTTAAAGGGTTCGAGCCTGATGTACGTATTTTGCTTACCAAATACAGCAATAGTAATGGCTCTCAGTC 
               
               
                   
               
               
                 CCCGTGGATGGAGGAGCAAATTCGGGATGCCTGGGGAAGCATGGTTCTAAAAAATGTTGTACGTGAA 
               
               
                   
               
               
                 ACGGATGAAGTTGGTAAAGGTCAGATCCGGATGAGAACTGTTTTTGAACAGGCCATTGATCAACGCT 
               
               
                   
               
               
                 CTTCAACTGGTGCCTGGAGAAATGCTCTTTCTATTTGGGAACCTGTCTGCAATGAAATTTTCGATCGT 
               
               
                   
               
               
                 CTGATTAAACCACGCTGGGAGATTAGATAATGAAGCGTGCGCCTGTTATTCCAAAACATACGCTCAA 
               
               
                   
               
               
                 TACTCAACCGGTTGAAGATACTTCGTTATCGACACCAGCTGCCCCGATGGTGGATTCGTTAATTGCGC 
               
               
                   
               
               
                 GCGTAGGAGTAATGGCTCGCGGTAATGCCATTACTTTGCCTGTATGTGGTCGGGATGTGAAGTTTACT 
               
               
                   
               
               
                 CTTGAAGTGCTCCGGGGTGATAGTGTTGAGAAGACCTCTCGGGTATGGTCAGGTAATGAACGTGACC 
               
               
                   
               
               
                 AGGAGCTGCTTACTGAGGACGCACTGGATGATCTCATCCCTTCTTTTCTACTGACTGGTCAACAGACA 
               
               
                   
               
               
                 CCGGCGTTCGGTCGAAGAGTATCTGGTGTCATAGAAATTGCCGATGGGAGTCGCCGTCGTAAAGCTG 
               
               
                   
               
               
                 CTGCACTTACCGAAAGTGATTATCGTGTTCTGGTTGGCGAGCTGGATGATGAGCAGATGGCTGCATT 
               
               
                   
               
               
                 ATCCAGATTGGGTAACGATTATCGCCCAACAAGTGCTTATGAACGTGGTCAGCGTTATGCAAGCCGA 
               
               
                   
               
               
                 TTGCAGAATGAATTTGCTGGAAATATTTCTGCGCTGGCTGATGCGGAAAATATTTCACGTAAGATTAT 
               
               
                   
               
               
                 TACCCGCTGTATCAACACCGCCAAATTGCCTAAATCAGTTGTTGCTCTTTTTTCTCACCCCGGTGAACT 
               
               
                   
               
               
                 ATCTGCCCGGTCAGGTGATGCACTTCAAAAAGCCTTTACAGATAAAGAGGAATTACTTAAGCAGCAG 
               
               
                   
               
               
                 GCATCTAACCTTCATGAGCAGAAAAAAGCTGGGGTGATATTTGAAGCTGAAGAAGTTATCACTCTTT 
               
               
                   
               
               
                 TAACTTCTGTGCTTAAAACGTCATCTGCATCAAGAACTAGTTTAAGCTCACGACATCAGTTTGCTCCT 
               
               
                   
               
               
                 GGAGCGACAGTATTGTATAAGGGCGATAAAATGGTGCTTAACCTGGACAGGTCTCGTGTTCCAACTG 
               
               
                   
               
               
                 AGTGTATAGAGAAAATTGAGGCCATTCTTAAGGAACTTGAAAAGCCAGCACCCTGATGCGACCACGT 
               
               
                   
               
               
                 TTTAGTCTACGTTTATCTGTCTTTACTTAATGTCCTTTGTTACAGGCCAGAAAGCATAACTGGCCTGAA 
               
               
                   
               
               
                 TATTCTCTCTGGGCCCACTGTTCCACTTGTATCGTCGGTCTGATAATCAGACTGGGACCACGGTCCCA 
               
               
                   
               
               
                 CTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTCGGTCTGATTATTAG 
               
               
                   
               
               
                 TCTGGGACCACGGTCCCACTCGTATCGTCGGTCTGATAATCAGACTGGGACCACGGTCCCACTCGTAT 
               
               
                   
               
               
                 CGTCGGTCTGATTATTAGTCTGGGACCATGGTCCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGA 
               
               
                   
               
               
                 CCACGGTCCCACTCGTATCGTCGGTCTGATTATTAGTCTGGAACCACGGTCCCACTCGTATCGTCGGT 
               
               
                   
               
               
                 CTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGAT 
               
               
                   
               
               
                 CCCACTCGTGTTGTCGGTCTGATTATCGGTCTGGGACCACGGTCCCACTTGTATTGTCGATCAGACTA 
               
               
                   
               
               
                 TCAGCGTGAGACTACGATTCCATCAATGCCTGTCAAGGGCAAGTATTGACATGTCGTCGTAACCTGT 
               
               
                   
               
               
                 AGAACGGAGTAACCTCGGTGTGCGGTTGTATGCCTGCTGTGGATTGCTGCTGTGTCCTGCTTATCCAC 
               
               
                   
               
               
                 AACATTTTGCGCACGGTTATGTGGACAAAATACCTGGTTACCCAGGCCGTGCCGGCACGTTAACCGG 
               
               
                   
               
               
                 GCTGCATCCGATGCAAGTGTGTCGCTGTCGACGAGCTCGCGAGCTCGGACATGAGGTTGCCCCGTAT 
               
               
                   
               
               
                 TCAGTGTCGCTGATTTGTATTGTCTGAAGTTGTTTTTACGTTAAGTTGATGCAGATCAATTAATACGAT 
               
               
                   
               
               
                 ACCTGCGTCATAATTGATTATTTGACGTGGTTTGATGGCCTCCACGCACGTTGTGATATGTAGATGAT 
               
               
                   
               
               
                 AATCATTATCACTTTACGGGTCCTTTCCGGTGATCCGACAGGTTACGGGGCGGCGACCTCGCGGGTTT 
               
               
                   
               
               
                 TCGCTATTTATGAAAATTTTCCGGTTTAAGGCGTTTCCGTTCTTCTTCGTCATAACTTAATGTTTTTATT 
               
               
                   
               
               
                 TAAAATACCCTCTGAAAAGAAAGGAAACGACAGGTGCTGAAAGCGAGCTTTTTGGCCTCTGTCGTTT 
               
               
                   
               
               
                 CCTTTCTCTGTTTTTGTCCGTGGAATGAACAATGGAAGTCCGAGCTCATCGCTAATAACTTCGTATAG 
               
               
                   
               
               
                 CATACATTATACGAAGTTATATTCGATGCGGCCGCAAGGGGTTCGCGTCAGCGGGTGTTGGCGGGTG 
               
               
                   
               
               
                 TCGGGGCTGGCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCGGTGTGAA 
               
               
                   
               
               
                 ATACCGCACAGATGCGTAAGGAGAAAATACCGCATCAGGCGCCATTCGCCATTCAGGCTGCGCAACT 
               
               
                   
               
               
                 GTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGC 
               
               
                   
               
               
                 AAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAGTGAA 
               
               
                   
               
               
                 TTGTAATACGACTCACTATAGGGCGAATTCGAGCTCGGTACCCGGGGATCCTCGTTTAAAC 
               
               
                   
               
               
                 Polynucleotide sequence encoding ChAd155#1375 backbone construct 
               
               
                 SEQ ID NO: 9 
                   
               
               
                 CATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGATGGGCGGCGCGGGGCG 
                   
               
               
                   
               
               
                 GGGCGCGGGGCGGGAGGCGGGTTTGGGGGCGGGCCGGCGGGCGGGGCGGTGTGGCGGAAGTGGAC 
               
               
                   
               
               
                 TTTGTAAGTGTGGCGGATGTGACTTGCTAGTGCCGGGCGCGGTAAAAGTGACGTTTTCCGTGCGCGA 
               
               
                   
               
               
                 CAACGCCCCCGGGAAGTGACATTTTTCCCGCGGTTTTTACCGGATGTTGTAGTGAATTTGGGCGTAAC 
               
               
                   
               
               
                 CAAGTAAGATTTGGCCATTTTCGCGGGAAAACTGAAACGGGGAAGTGAAATCTGATTAATTTTGCGT 
               
               
                   
               
               
                 TAGTCATACCGCGTAATATTTGTCTAGGGCCGAGGGACTTTGGCCGATTACGTGGAGGACTCGCCCA 
               
               
                   
               
               
                 GGTGTTTTTTGAGGTGAATTTCCGCGTTCCGGGTCAAAGTCTGCGTTTTATTATTATAGGATATCCCAT 
               
               
                   
               
               
                 TGCATACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTT 
               
               
                   
               
               
                 GACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATG 
               
               
                   
               
               
                 GAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCAT 
               
               
                   
               
               
                 TGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGT 
               
               
                   
               
               
                 GGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCT 
               
               
                   
               
               
                 ATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCC 
               
               
                   
               
               
                 TACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCA 
               
               
                   
               
               
                 ATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAG 
               
               
                   
               
               
                 TTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAA 
               
               
                   
               
               
                 TGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCCCTATCAGTGATAGAGATCT 
               
               
                   
               
               
                 CCCTATCAGTGATAGAGATCGTCGACGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT 
               
               
                   
               
               
                 CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGCGGCCGGGAACGGTGCA 
               
               
                   
               
               
                 TTGGAACGCGGATTCCCCGTGCCAAGAGTGAGATCTTCCGTTTATCTAGGTACCGGGCCCCCCCTCGA 
               
               
                   
               
               
                 GGTCGACGGTATCGATAAGCTTCACGCTGCCGCAAGCACTCAGGGCGCAAGGGCTGCTAAAGGAAG 
               
               
                   
               
               
                 CGGAACACGTAGAAAGCCAGTCCGCAGAAACGGTGCTGACCCCGGATGAATGTCAGCTACTGGGCT 
               
               
                   
               
               
                 ATCTGGACAAGGGAAAACGCAAGCGCAAAGAGAAAGCAGGTAGCTTGCAGTGGGCTTACATGGCGA 
               
               
                   
               
               
                 TAGCTAGACTGGGCGGTTTTATGGACAGCAAGCGAACCGGAATTGCCAGCTGGGGCGCCCTCTGGTA 
               
               
                   
               
               
                 AGGTTGGGAAGCCCTGCAAAGTAAACTGGATGGCTTTCTTGCCGCCAAGGATCTGATGGCGCAGGGG 
               
               
                   
               
               
                 ATCAAGATCTAACCAGGAGCTATTTAATGGCAACAGTTAACCAGCTGGTACGCAAACCACGTGCTCG 
               
               
                   
               
               
                 CAAAGTTGCGAAAAGCAACGTGCCTGCGCTGGAAGCATGCCCGCAAAAACGTGGCGTATGTACTCGT 
               
               
                   
               
               
                 GTATATACTACCACTCCTAAAAAACCGAACTCCGCGCTGCGTAAAGTATGCCGTGTTCGTCTGACTAA 
               
               
                   
               
               
                 CGGTTTCGAAGTGACTTCCTACATCGGTGGTGAAGGTCACAACCTGCAGGAGCACTCCGTGATCCTG 
               
               
                   
               
               
                 ATCCGTGGCGGTCGTGTTAAAGACCTCCCGGGTGTTCGTTACCACACCGTACGTGGTGCGCTTGACTG 
               
               
                   
               
               
                 CTCCGGCGTTAAAGACCGTAAGCAGGCTCGTTCCAAGTATGGCGTGAAGCGTCCTAAGGCTTAATGG 
               
               
                   
               
               
                 TAGATCTGATCAAGAGACAGGATGACGGTCGTTTCGCATGCTTGAACAAGATGGATTGCACGCAGGT 
               
               
                   
               
               
                 TCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTG 
               
               
                   
               
               
                 ATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGT 
               
               
                   
               
               
                 GCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCG 
               
               
                   
               
               
                 CAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCA 
               
               
                   
               
               
                 GGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGC 
               
               
                   
               
               
                 TGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACG 
               
               
                   
               
               
                 TACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCA 
               
               
                   
               
               
                 GCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCG 
               
               
                   
               
               
                 ATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTG 
               
               
                   
               
               
                 GGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCG 
               
               
                   
               
               
                 AATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTAT 
               
               
                   
               
               
                 CGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAA 
               
               
                   
               
               
                 CCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCC 
               
               
                   
               
               
                 GGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCGGGCT 
               
               
                   
               
               
                 CGATCCCCTCGGGGGGAATCAGAATTCAGTCGACAGCGGCCGCGATCTGCTGTGCCTTCTAGTTGCC 
               
               
                   
               
               
                 AGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTT 
               
               
                   
               
               
                 CCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGT 
               
               
                   
               
               
                 GGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCT 
               
               
                   
               
               
                 CTATGGCCGATCAGCGATCGCTGAGGTGGGTGAGTGGGCGTGGCCTGGGGTGGTCATGAAAATATAT 
               
               
                   
               
               
                 AAGTTGGGGGTCTTAGGGTCTCTTTATTTGTGTTGCAGAGACCGCCGGAGCCATGAGCGGGAGCAGC 
               
               
                   
               
               
                 AGCAGCAGCAGTAGCAGCAGCGCCTTGGATGGCAGCATCGTGAGCCCTTATTTGACGACGCGGATGC 
               
               
                   
               
               
                 CCCACTGGGCCGGGGTGCGTCAGAATGTGATGGGCTCCAGCATCGACGGCCGACCCGTCCTGCCCGC 
               
               
                   
               
               
                 AAATTCCGCCACGCTGACCTATGCGACCGTCGCGGGGACGCCGTTGGACGCCACCGCCGCCGCCGCC 
               
               
                   
               
               
                 GCCACCGCAGCCGCCTCGGCCGTGCGCAGCCTGGCCACGGACTTTGCATTCCTGGGACCACTGGCGA 
               
               
                   
               
               
                 CAGGGGCTACTTCTCGGGCCGCTGCTGCCGCCGTTCGCGATGACAAGCTGACCGCCCTGCTGGCGCA 
               
               
                   
               
               
                 GTTGGATGCGCTTACTCGGGAACTGGGTGACCTTTCTCAGCAGGTCATGGCCCTGCGCCAGCAGGTCT 
               
               
                   
               
               
                 CCTCCCTGCAAGCTGGCGGGAATGCTTCTCCCACAAATGCCGTTTAAGATAAATAAAACCAGACTCT 
               
               
                   
               
               
                 GTTTGGATTAAAGAAAAGTAGCAAGTGCATTGCTCTCTTTATTTCATAATTTTCCGCGCGCGATAGGC 
               
               
                   
               
               
                 CCTAGACCAGCGTTCTCGGTCGTTGAGGGTGCGGTGTATCTTCTCCAGGACGTGGTAGAGGTGGCTCT 
               
               
                   
               
               
                 GGACGTTGAGATACATGGGCATGAGCCCGTCCCGGGGGTGGAGGTAGCACCACTGCAGAGCTTCATG 
               
               
                   
               
               
                 CTCCGGGGTGGTGTTGTAGATGATCCAGTCGTAGCAGGAGCGCTGGGCATGGTGCCTAAAAATGTCC 
               
               
                   
               
               
                 TTCAGCAGCAGGCCGATGGCCAGGGGGAGGCCCTTGGTGTAAGTGTTTACAAAACGGTTAAGTTGGG 
               
               
                   
               
               
                 AAGGGTGCATTCGGGGAGAGATGATGTGCATCTTGGACTGTATTTTTAGATTGGCGATGTTTCCGCCC 
               
               
                   
               
               
                 AGATCCCTTCTGGGATTCATGTTGTGCAGGACCACCAGTACAGTGTATCCGGTGCACTTGGGGAATTT 
               
               
                   
               
               
                 GTCATGCAGCTTAGAGGGAAAAGCGTGGAAGAACTTGGAGACGCCTTTGTGGCCTCCCAGATTTTCC 
               
               
                   
               
               
                 ATGCATTCGTCCATGATGATGGCAATGGGCCCGCGGGAGGCAGCTTGGGCAAAGATATTTCTGGGGT 
               
               
                   
               
               
                 CGCTGACGTCGTAGTTGTGTTCCAGGGTGAGGTCGTCATAGGCCATTTTTACAAAGCGCGGGCGGAG 
               
               
                   
               
               
                 GGTGCCCGACTGGGGGATGATGGTCCCCTCTGGCCCTGGGGCGTAGTTGCCCTCGCAGATCTGCATTT 
               
               
                   
               
               
                 CCCAGGCCTTAATCTCGGAGGGGGGAATCATATCCACCTGCGGGGCGATGAAGAAAACGGTTTCCGG 
               
               
                   
               
               
                 AGCCGGGGAGATTAACTGGGATGAGAGCAGGTTTCTAAGCAGCTGTGATTTTCCACAACCGGTGGGC 
               
               
                   
               
               
                 CCATAAATAACACCTATAACCGGTTGCAGCTGGTAGTTTAGAGAGCTGCAGCTGCCGTCGTCCCGGA 
               
               
                   
               
               
                 GGAGGGGGGCCACCTCGTTGAGCATGTCCCTGACGCGCATGTTCTCCCCGACCAGATCCGCCAGAAG 
               
               
                   
               
               
                 GCGCTCGCCGCCCAGGGACAGCAGCTCTTGCAAGGAAGCAAAGTTTTTCAGCGGCTTGAGGCCGTCC 
               
               
                   
               
               
                 GCCGTGGGCATGTTTTTCAGGGTCTGGCTCAGCAGCTCCAGGCGGTCCCAGAGCTCGGTGACGTGCT 
               
               
                   
               
               
                 CTACGGCATCTCTATCCAGCATATCTCCTCGTTTCGCGGGTTGGGGCGACTTTCGCTGTAGGGCACCA 
               
               
                   
               
               
                 AGCGGTGGTCGTCCAGCGGGGCCAGAGTCATGTCCTTCCATGGGCGCAGGGTCCTCGTCAGGGTGGT 
               
               
                   
               
               
                 CTGGGTCACGGTGAAGGGGTGCGCTCCGGGCTGAGCGCTTGCCAAGGTGCGCTTGAGGCTGGTTCTG 
               
               
                   
               
               
                 CTGGTGCTGAAGCGCTGCCGGTCTTCGCCCTGCGCGTCGGCCAGGTAGCATTTGACCATGGTGTCATA 
               
               
                   
               
               
                 GTCCAGCCCCTCCGCGGCGTGTCCCTTGGCGCGCAGCTTGCCCTTGGAGGTGGCGCCGCACGAGGGG 
               
               
                   
               
               
                 CAGAGCAGGCTCTTGAGCGCGTAGAGCTTGGGGGCGAGGAAGACCGATTCGGGGGAGTAGGCGTCC 
               
               
                   
               
               
                 GCGCCGCAGACCCCGCACACGGTCTCGCACTCCACCAGCCAGGTGAGCTCGGGGCGCGCCGGGTCAA 
               
               
                   
               
               
                 AAACCAGGTTTCCCCCATGCTTTTTGATGCGTTTCTTACCTCGGGTCTCCATGAGGTGGTGTCCCCGCT 
               
               
                   
               
               
                 CGGTGACGAAGAGGCTGTCCGTGTCTCCGTAGACCGACTTGAGGGGTCTTTTCTCCAGGGGGGTCCC 
               
               
                   
               
               
                 TCGGTCTTCCTCGTAGAGGAACTCGGACCACTCTGAGACGAAGGCCCGCGTCCAGGCCAGGACGAAG 
               
               
                   
               
               
                 GAGGCTATGTGGGAGGGGTAGCGGTCGTTGTCCACTAGGGGGTCCACCTTCTCCAAGGTGTGAAGAC 
               
               
                   
               
               
                 ACATGTCGCCTTCCTCGGCGTCCAGGAAGGTGATTGGCTTGTAGGTGTAGGCCACGTGACCGGGGGT 
               
               
                   
               
               
                 TCCTGACGGGGGGGTATAAAAGGGGGTGGGGGCGCGCTCGTCGTCACTCTCTTCCGCATCGCTGTCT 
               
               
                   
               
               
                 GCGAGGGCCAGCTGCTGGGGTGAGTATTCCCTCTCGAAGGCGGGCATGACCTCCGCGCTGAGGTTGT 
               
               
                   
               
               
                 CAGTTTCCAAAAACGAGGAGGATTTGATGTTCACCTGTCCCGAGGTGATACCTTTGAGGGTACCCGC 
               
               
                   
               
               
                 GTCCATCTGGTCAGAAAACACGATCTTTTTATTGTCCAGCTTGGTGGCGAACGACCCGTAGAGGGCG 
               
               
                   
               
               
                 TTGGAGAGCAGCTTGGCGATGGAGCGCAGGGTCTGGTTCTTGTCCCTGTCGGCGCGCTCCTTGGCCGC 
               
               
                   
               
               
                 GATGTTGAGCTGCACGTACTCGCGCGCGACGCAGCGCCACTCGGGGAAGACGGTGGTGCGCTCGTCG 
               
               
                   
               
               
                 GGCACCAGGCGCACGCGCCAGCCGCGGTTGTGCAGGGTGACCAGGTCCACGCTGGTGGCGACCTCGC 
               
               
                   
               
               
                 CGCGCAGGCGCTCGTTGGTCCAGCAGAGACGGCCGCCCTTGCGCGAGCAGAAGGGGGGCAGGGGGT 
               
               
                   
               
               
                 CGAGCTGGGTCTCGTCCGGGGGGTCCGCGTCCACGGTGAAAACCCCGGGGCGCAGGCGCGCGTCGA 
               
               
                   
               
               
                 AGTAGTCTATCTTGCAACCTTGCATGTCCAGCGCCTGCTGCCAGTCGCGGGCGGCGAGCGCGCGCTC 
               
               
                   
               
               
                 GTAGGGGTTGAGCGGCGGGCCCCAGGGCATGGGGTGGGTGAGTGCGGAGGCGTACATGCCGCAGAT 
               
               
                   
               
               
                 GTCATAGACGTAGAGGGGCTCCCGCAGGACCCCGATGTAGGTGGGGTAGCAGCGGCCGCCGCGGAT 
               
               
                   
               
               
                 GCTGGCGCGCACGTAGTCATACAGCTCGTGCGAGGGGGCGAGGAGGTCGGGGCCCAGGTTGGTGCG 
               
               
                   
               
               
                 GGCGGGGCGCTCCGCGCGGAAGACGATCTGCCTGAAGATGGCATGCGAGTTGGAAGAGATGGTGGG 
               
               
                   
               
               
                 GCGCTGGAAGACGTTGAAGCTGGCGTCCTGCAGGCCGACGGCGTCGCGCACGAAGGAGGCGTAGGA 
               
               
                   
               
               
                 GTCGCGCAGCTTGTGTACCAGCTCGGCGGTGACCTGCACGTCGAGCGCGCAGTAGTCGAGGGTCTCG 
               
               
                   
               
               
                 CGGATGATGTCATATTTAGCCTGCCCCTTCTTTTTCCACAGCTCGCGGTTGAGGACAAACTCTTCGCG 
               
               
                   
               
               
                 GTCTTTCCAGTACTCTTGGATCGGGAAACCGTCCGGTTCCGAACGGTAAGAGCCTAGCATGTAGAAC 
               
               
                   
               
               
                 TGGTTGACGGCCTGGTAGGCGCAGCAGCCCTTCTCCACGGGGAGGGCGTAGGCCTGCGCGGCCTTGC 
               
               
                   
               
               
                 GGAGCGAGGTGTGGGTCAGGGCGAAGGTGTCCCTGACCATGACTTTGAGGTACTGGTGCTTGAAGTC 
               
               
                   
               
               
                 GGAGTCGTCGCAGCCGCCCCGCTCCCAGAGCGAGAAGTCGGTGCGCTTCTTGGAGCGGGGGTTGGGC 
               
               
                   
               
               
                 AGAGCGAAGGTGACATCGTTGAAGAGGATTTTGCCCGCGCGGGGCATGAAGTTGCGGGTGATGCGG 
               
               
                   
               
               
                 AAGGGCCCCGGCACTTCAGAGCGGTTGTTGATGACCTGGGCGGCGAGCACGATCTCGTCGAAGCCGT 
               
               
                   
               
               
                 TGATGTTGTGGCCCACGATGTAGAGTTCCAGGAAGCGGGGCCGGCCCTTTACGGTGGGCAGCTTCTT 
               
               
                   
               
               
                 TAGCTCTTCGTAGGTGAGCTCCTCGGGCGAGGCGAGGCCGTGCTCGGCCAGGGCCCAGTCCGCGAGG 
               
               
                   
               
               
                 TGCGGGTTGTCTCTGAGGAAGGACTTCCAGAGGTCGCGGGCCAGGAGGGTCTGCAGGCGGTCTCTGA 
               
               
                   
               
               
                 AGGTCCTGAACTGGCGGCCCACGGCCATTTTTTCGGGGGTGATGCAGTAGAAGGTGAGGGGGTCTTG 
               
               
                   
               
               
                 CTGCCAGCGGTCCCAGTCGAGCTGCAGGGCGAGGTCGCGCGCGGCGGTGACCAGGCGCTCGTCGCCC 
               
               
                   
               
               
                 CCGAATTTCATGACCAGCATGAAGGGCACGAGCTGCTTTCCGAAGGCCCCCATCCAAGTGTAGGTCT 
               
               
                   
               
               
                 CTACATCGTAGGTGACAAAGAGGCGCTCCGTGCGAGGATGCGAGCCGATCGGGAAGAACTGGATCT 
               
               
                   
               
               
                 CCCGCCACCAGTTGGAGGAGTGGCTGTTGATGTGGTGGAAGTAGAAGTCCCGTCGCCGGGCCGAACA 
               
               
                   
               
               
                 CTCGTGCTGGCTTTTGTAAAAGCGAGCGCAGTACTGGCAGCGCTGCACGGGCTGTACCTCATGCACG 
               
               
                   
               
               
                 AGATGCACCTTTCGCCCGCGCACGAGGAAGCCGAGGGGAAATCTGAGCCCCCCGCCTGGCTCGCGGC 
               
               
                   
               
               
                 ATGGCTGGTTCTCTTCTACTTTGGATGCGTGTCCGTCTCCGTCTGGCTCCTCGAGGGGTGTTACGGTG 
               
               
                   
               
               
                 GAGCGGACCACCACGCCGCGCGAGCCGCAGGTCCAGATATCGGCGCGCGGCGGTCGGAGTTTGATG 
               
               
                   
               
               
                 ACGACATCGCGCAGCTGGGAGCTGTCCATGGTCTGGAGCTCCCGCGGCGGCGGCAGGTCAGCCGGG 
               
               
                   
               
               
                 AGTTCTTGCAGGTTCACCTCGCAGAGTCGGGCCAGGGCGCGGGGCAGGTCTAGGTGGTACCTGATCT 
               
               
                   
               
               
                 CTAGGGGCGTGTTGGTGGCGGCGTCGATGGCTTGCAGGAGCCCGCAGCCCCGGGGGGCGACGACGG 
               
               
                   
               
               
                 TGCCCCGCGGGGTGGTGGTGGTGGTGGCGGTGCAGCTCAGAAGCGGTGCCGCGGGCGGGCCCCCGG 
               
               
                   
               
               
                 AGGTAGGGGGGGCTCCGGTCCCGCGGGCAGGGGCGGCAGCGGCACGTCGGCGTGGAGCGCGGGCAG 
               
               
                   
               
               
                 GAGTTGGTGCTGTGCCCGGAGGTTGCTGGCGAAGGCGACGACGCGGCGGTTGATCTCCTGGATCTGG 
               
               
                   
               
               
                 CGCCTCTGCGTGAAGACGACGGGCCCGGTGAGCTTGAACCTGAAAGAGAGTTCGACAGAATCAATCT 
               
               
                   
               
               
                 CGGTGTCATTGACCGCGGCCTGGCGCAGGATCTCCTGCACGTCTCCCGAGTTGTCTTGGTAGGCGATC 
               
               
                   
               
               
                 TCGGCCATGAACTGCTCGATCTCTTCCTCCTGGAGGTCTCCGCGTCCGGCGCGTTCCACGGTGGCCGC 
               
               
                   
               
               
                 CAGGTCGTTGGAGATGCGCCCCATGAGCTGCGAGAAGGCGTTGAGTCCGCCCTCGTTCCAGACTCGG 
               
               
                   
               
               
                 CTGTAGACCACGCCCCCCTGGTCATCGCGGGCGCGCATGACCACCTGCGCGAGGTTGAGCTCCACGT 
               
               
                   
               
               
                 GCCGCGCGAAGACGGCGTAGTTGCGCAGACGCTGGAAGAGGTAGTTGAGGGTGGTGGCGGTGTGCT 
               
               
                   
               
               
                 CGGCCACGAAGAAGTTCATGACCCAGCGGCGCAACGTGGATTCGTTGATGTCCCCCAAGGCCTCCAG 
               
               
                   
               
               
                 CCGTTCCATGGCCTCGTAGAAGTCCACGGCGAAGTTGAAAAACTGGGAGTTGCGCGCCGACACGGTC 
               
               
                   
               
               
                 AACTCCTCCTCCAGAAGACGGATGAGCTCGGCGACGGTGTCGCGCACCTCGCGCTCGAAGGCTATGG 
               
               
                   
               
               
                 GGATCTCTTCCTCCGCTAGCATCACCACCTCCTCCTCTTCCTCCTCTTCTGGCACTTCCATGATGGCTT 
               
               
                   
               
               
                 CCTCCTCTTCGGGGGGTGGCGGCGGCGGCGGTGGGGGAGGGGGCGCTCTGCGCCGGCGGCGGCGCA 
               
               
                   
               
               
                 CCGGGAGGCGGTCCACGAAGCGCGCGATCATCTCCCCGCGGCGGCGGCGCATGGTCTCGGTGACGGC 
               
               
                   
               
               
                 GCGGCCGTTCTCCCGGGGGCGCAGTTGGAAGACGCCGCCGGACATCTGGTGCTGGGGCGGGTGGCCG 
               
               
                   
               
               
                 TGAGGCAGCGAGACGGCGCTGACGATGCATCTCAACAATTGCTGCGTAGGTACGCCGCCGAGGGAC 
               
               
                   
               
               
                 CTGAGGGAGTCCATATCCACCGGATCCGAAAACCTTTCGAGGAAGGCGTCTAACCAGTCGCAGTCGC 
               
               
                   
               
               
                 AAGGTAGGCTGAGCACCGTGGCGGGCGGCGGGGGGTGGGGGGAGTGTCTGGCGGAGGTGCTGCTGA 
               
               
                   
               
               
                 TGATGTAATTGAAGTAGGCGGACTTGACACGGCGGATGGTCGACAGGAGCACCATGTCCTTGGGTCC 
               
               
                   
               
               
                 GGCCTGCTGGATGCGGAGGCGGTCGGCTATGCCCCAGGCTTCGTTCTGGCATCGGCGCAGGTCCTTG 
               
               
                   
               
               
                 TAGTAGTCTTGCATGAGCCTTTCCACCGGCACCTCTTCTCCTTCCTCTTCTGCTTCTTCCATGTCTGCTT 
               
               
                   
               
               
                 CGGCCCTGGGGCGGCGCCGCGCCCCCCTGCCCCCCATGCGCGTGACCCCGAACCCCCTGAGCGGTTG 
               
               
                   
               
               
                 GAGCAGGGCCAGGTCGGCGACGACGCGCTCGGCCAGGATGGCCTGCTGCACCTGCGTGAGGGTGGT 
               
               
                   
               
               
                 TTGGAAGTCATCCAAGTCCACGAAGCGGTGGTAGGCGCCCGTGTTGATGGTGTAGGTGCAGTTGGCC 
               
               
                   
               
               
                 ATGACGGACCAGTTGACGGTCTGGTGGCCCGGTTGCGACATCTCGGTGTACCTGAGTCGCGAGTAGG 
               
               
                   
               
               
                 CGCGGGAGTCGAAGACGTAGTCGTTGCAAGTCCGCACCAGGTACTGGTAGCCCACCAGGAAGTGCG 
               
               
                   
               
               
                 GCGGCGGCTGGCGGTAGAGGGGCCAGCGCAGGGTGGCGGGGGCTCCGGGGGCCAGGTCTTCCAGCA 
               
               
                   
               
               
                 TGAGGCGGTGGTAGGCGTAGATGTACCTGGACATCCAGGTGATACCCGCGGCGGTGGTGGAGGCGC 
               
               
                   
               
               
                 GCGGGAAGTCGCGCACCCGGTTCCAGATGTTGCGCAGGGGCAGAAAGTGCTCCATGGTAGGCGTGCT 
               
               
                   
               
               
                 CTGTCCAGTCAGACGCGCGCAGTCGTTGATACTCTAGACCAGGGAAAACGAAAGCCGGTCAGCGGG 
               
               
                   
               
               
                 CACTCTTCCGTGGTCTGGTGAATAGATCGCAAGGGTATCATGGCGGAGGGCCTCGGTTCGAGCCCCG 
               
               
                   
               
               
                 GGTCCGGGCCGGACGGTCCGCCATGATCCACGCGGTTACCGCCCGCGTGTCGAACCCAGGTGTGCGA 
               
               
                   
               
               
                 CGTCAGACAACGGTGGAGTGTTCCTTTTGGCGTTTTTCTGGCCGGGCGCCGGCGCCGCGTAAGAGAC 
               
               
                   
               
               
                 TAAGCCGCGAAAGCGAAAGCAGTAAGTGGCTCGCTCCCCGTAGCCGGAGGGATCCTTGCTAAGGGTT 
               
               
                   
               
               
                 GCGTTGCGGCGAACCCCGGTTCGAATCCCGTACTCGGGCCGGCCGGACCCGCGGCTAAGGTGTTGGA 
               
               
                   
               
               
                 TTGGCCTCCCCCTCGTATAAAGACCCCGCTTGCGGATTGACTCCGGACACGGGGACGAGCCCCTTTTA 
               
               
                   
               
               
                 TTTTTGCTTTCCCCAGATGCATCCGGTGCTGCGGCAGATGCGCCCCCCGCCCCAGCAGCAGCAACAAC 
               
               
                   
               
               
                 ACCAGCAAGAGCGGCAGCAACAGCAGCGGGAGTCATGCAGGGCCCCCTCACCCACCCTCGGCGGGC 
               
               
                   
               
               
                 CGGCCACCTCGGCGTCCGCGGCCGTGTCTGGCGCCTGCGGCGGCGGCGGGGGGCCGGCTGACGACCC 
               
               
                   
               
               
                 CGAGGAGCCCCCGCGGCGCAGGGCCAGACACTACCTGGACCTGGAGGAGGGCGAGGGCCTGGCGCG 
               
               
                   
               
               
                 GCTGGGGGCGCCGTCTCCCGAGCGCCACCCGCGGGTGCAGCTGAAGCGCGACTCGCGCGAGGCGTA 
               
               
                   
               
               
                 CGTGCCTCGGCAGAACCTGTTCAGGGACCGCGCGGGCGAGGAGCCCGAGGAGATGCGGGACAGGAG 
               
               
                   
               
               
                 GTTCAGCGCAGGGCGGGAGCTGCGGCAGGGGCTGAACCGCGAGCGGCTGCTGCGCGAGGAGGACTT 
               
               
                   
               
               
                 TGAGCCCGACGCGCGGACGGGGATCAGCCCCGCGCGCGCGCACGTGGCGGCCGCCGACCTGGTGAC 
               
               
                   
               
               
                 GGCGTACGAGCAGACGGTGAACCAGGAGATCAACTTCCAAAAGAGTTTCAACAACCACGTGCGCAC 
               
               
                   
               
               
                 GCTGGTGGCGCGCGAGGAGGTGACCATCGGGCTGATGCACCTGTGGGACTTTGTAAGCGCGCTGGTG 
               
               
                   
               
               
                 CAGAACCCCAACAGCAAGCCTCTGACGGCGCAGCTGTTCCTGATAGTGCAGCACAGCAGGGACAAC 
               
               
                   
               
               
                 GAGGCGTTTAGGGACGCGCTGCTGAACATCACCGAGCCCGAGGGTCGGTGGCTGCTGGACCTGATTA 
               
               
                   
               
               
                 ACATCCTGCAGAGCATAGTGGTGCAGGAGCGCAGCCTGAGCCTGGCCGACAAGGTGGCGGCCATCA 
               
               
                   
               
               
                 ACTACTCGATGCTGAGCCTGGGCAAGTTTTACGCGCGCAAGATCTACCAGACGCCGTACGTGCCCAT 
               
               
                   
               
               
                 AGACAAGGAGGTGAAGATCGACGGTTTTTACATGCGCATGGCGCTGAAGGTGCTCACCCTGAGCGAC 
               
               
                   
               
               
                 GACCTGGGCGTGTACCGCAACGAGCGCATCCACAAGGCCGTGAGCGTGAGCCGGCGGCGCGAGCTG 
               
               
                   
               
               
                 AGCGACCGCGAGCTGATGCACAGCCTGCAGCGGGCGCTGGCGGGCGCCGGCAGCGGCGACAGGGAG 
               
               
                   
               
               
                 GCGGAGTCCTACTTCGATGCGGGGGCGGACCTGCGCTGGGCGCCCAGCCGGCGGGCCCTGGAGGCC 
               
               
                   
               
               
                 GCGGGGGTCCGCGAGGACTATGACGAGGACGGCGAGGAGGATGAGGAGTACGAGCTAGAGGAGGG 
               
               
                   
               
               
                 CGAGTACCTGGACTAAACCGCGGGTGGTGTTTCCGGTAGATGCAAGACCCGAACGTGGTGGACCCGG 
               
               
                   
               
               
                 CGCTGCGGGCGGCTCTGCAGAGCCAGCCGTCCGGCCTTAACTCCTCAGACGACTGGCGACAGGTCAT 
               
               
                   
               
               
                 GGACCGCATCATGTCGCTGACGGCGCGTAACCCGGACGCGTTCCGGCAGCAGCCGCAGGCCAACAG 
               
               
                   
               
               
                 GCTCTCCGCCATCCTGGAGGCGGTGGTGCCTGCGCGCTCGAACCCCACGCACGAGAAGGTGCTGGCC 
               
               
                   
               
               
                 ATAGTGAACGCGCTGGCCGAGAACAGGGCCATCCGCCCGGACGAGGCCGGGCTGGTGTACGACGCG 
               
               
                   
               
               
                 CTGCTGCAGCGCGTGGCCCGCTACAACAGCGGCAACGTGCAGACCAACCTGGACCGGCTGGTGGGG 
               
               
                   
               
               
                 GACGTGCGCGAGGCGGTGGCGCAGCGCGAGCGCGCGGATCGGCAGGGCAACCTGGGCTCCATGGTG 
               
               
                   
               
               
                 GCGCTGAATGCCTTCCTGAGCACGCAGCCGGCCAACGTGCCGCGGGGGCAGGAAGACTACACCAAC 
               
               
                   
               
               
                 TTTGTGAGCGCGCTGCGGCTGATGGTGACCGAGACCCCCCAGAGCGAGGTGTACCAGTCGGGCCCGG 
               
               
                   
               
               
                 ACTACTTCTTCCAGACCAGCAGACAGGGCCTGCAGACGGTGAACCTGAGCCAGGCTTTCAAGAACCT 
               
               
                   
               
               
                 GCGGGGGCTGTGGGGCGTGAAGGCGCCCACCGGCGACCGGGCGACGGTGTCCAGCCTGCTGACGCC 
               
               
                   
               
               
                 CAACTCGCGCCTGCTGCTGCTGCTGATCGCGCCGTTCACGGACAGCGGCAGCGTGTCCCGGGACACC 
               
               
                   
               
               
                 TACCTGGGGCACCTGCTGACCCTGTACCGCGAGGCCATCGGGCAGGCGCAGGTGGACGAGCACACCT 
               
               
                   
               
               
                 TCCAGGAGATCACCAGCGTGAGCCGCGCGCTGGGGCAGGAGGACACGAGCAGCCTGGAGGCGACTC 
               
               
                   
               
               
                 TGAACTACCTGCTGACCAACCGGCGGCAGAAGATTCCCTCGCTGCACAGCCTGACCTCCGAGGAGGA 
               
               
                   
               
               
                 GCGCATCTTGCGCTACGTGCAGCAGAGCGTGAGCCTGAACCTGATGCGCGACGGGGTGACGCCCAGC 
               
               
                   
               
               
                 GTGGCGCTGGACATGACCGCGCGCAACATGGAACCGGGCATGTACGCCGCGCACCGGCCTTACATCA 
               
               
                   
               
               
                 ACCGCCTGATGGACTACCTGCATCGCGCGGCGGCCGTGAACCCCGAGTACTTTACCAACGCCATCCT 
               
               
                   
               
               
                 GAACCCGCACTGGCTCCCGCCGCCCGGGTTCTACAGCGGGGGCTTCGAGGTCCCGGAGACCAACGAT 
               
               
                   
               
               
                 GGCTTCCTGTGGGACGACATGGACGACAGCGTGTTCTCCCCGCGGCCGCAGGCGCTGGCGGAAGCGT 
               
               
                   
               
               
                 CCCTGCTGCGTCCCAAGAAGGAGGAGGAGGAGGAGGCGAGTCGCCGCCGCGGCAGCAGCGGCGTGG 
               
               
                   
               
               
                 CTTCTCTGTCCGAGCTGGGGGCGGCAGCCGCCGCGCGCCCCGGGTCCCTGGGCGGCAGCCCCTTTCC 
               
               
                   
               
               
                 GAGCCTGGTGGGGTCTCTGCACAGCGAGCGCACCACCCGCCCTCGGCTGCTGGGCGAGGACGAGTAC 
               
               
                   
               
               
                 CTGAATAACTCCCTGCTGCAGCCGGTGCGGGAGAAAAACCTGCCTCCCGCCTTCCCCAACAACGGGA 
               
               
                   
               
               
                 TAGAGAGCCTGGTGGACAAGATGAGCAGATGGAAGACCTATGCGCAGGAGCACAGGGACGCGCCTG 
               
               
                   
               
               
                 CGCTCCGGCCGCCCACGCGGCGCCAGCGCCACGACCGGCAGCGGGGGCTGGTGTGGGATGACGAGG 
               
               
                   
               
               
                 ACTCCGCGGACGATAGCAGCGTGCTGGACCTGGGAGGGAGCGGCAACCCGTTCGCGCACCTGCGCCC 
               
               
                   
               
               
                 CCGCCTGGGGAGGATGTTTTAAAAAAAAAAAAAAAAAGCAAGAAGCATGATGCAAAAATTAAATAA 
               
               
                   
               
               
                 AACTCACCAAGGCCATGGCGACCGAGCGTTGGTTTCTTGTGTTCCCTTCAGTATGCGGCGCGCGGCG 
               
               
                   
               
               
                 ATGTACCAGGAGGGACCTCCTCCCTCTTACGAGAGCGTGGTGGGCGCGGCGGCGGCGGCGCCCTCTT 
               
               
                   
               
               
                 CTCCCTTTGCGTCGCAGCTGCTGGAGCCGCCGTACGTGCCTCCGCGCTACCTGCGGCCTACGGGGGG 
               
               
                   
               
               
                 GAGAAACAGCATCCGTTACTCGGAGCTGGCGCCCCTGTTCGACACCACCCGGGTGTACCTGGTGGAC 
               
               
                   
               
               
                 AACAAGTCGGCGGACGTGGCCTCCCTGAACTACCAGAACGACCACAGCAATTTTTTGACCACGGTCA 
               
               
                   
               
               
                 TCCAGAACAATGACTACAGCCCGAGCGAGGCCAGCACCCAGACCATCAATCTGGATGACCGGTCGC 
               
               
                   
               
               
                 ACTGGGGCGGCGACCTGAAAACCATCCTGCACACCAACATGCCCAACGTGAACGAGTTCATGTTCAC 
               
               
                   
               
               
                 CAATAAGTTCAAGGCGCGGGTGATGGTGTCGCGCTCGCACACCAAGGAAGACCGGGTGGAGCTGAA 
               
               
                   
               
               
                 GTACGAGTGGGTGGAGTTCGAGCTGCCAGAGGGCAACTACTCCGAGACCATGACCATTGACCTGATG 
               
               
                   
               
               
                 AACAACGCGATCGTGGAGCACTATCTGAAAGTGGGCAGGCAGAACGGGGTCCTGGAGAGCGACATC 
               
               
                   
               
               
                 GGGGTCAAGTTCGACACCAGGAACTTCCGCCTGGGGCTGGACCCCGTGACCGGGCTGGTTATGCCCG 
               
               
                   
               
               
                 GGGTGTACACCAACGAGGCCTTCCATCCCGACATCATCCTGCTGCCCGGCTGCGGGGTGGACTTCAC 
               
               
                   
               
               
                 TTACAGCCGCCTGAGCAACCTCCTGGGCATCCGCAAGCGGCAGCCCTTCCAGGAGGGCTTCAGGATC 
               
               
                   
               
               
                 ACCTACGAGGACCTGGAGGGGGGCAACATCCCCGCGCTCCTCGATGTGGAGGCCTACCAGGATAGCT 
               
               
                   
               
               
                 TGAAGGAAAATGAGGCGGGACAGGAGGATACCGCCCCCGCCGCCTCCGCCGCCGCCGAGCAGGGCG 
               
               
                   
               
               
                 AGGATGCTGCTGACACCGCGGCCGCGGACGGGGCAGAGGCCGACCCCGCTATGGTGGTGGAGGCTC 
               
               
                   
               
               
                 CCGAGCAGGAGGAGGACATGAATGACAGTGCGGTGCGCGGAGACACCTTCGTCACCCGGGGGGAGG 
               
               
                   
               
               
                 AAAAGCAAGCGGAGGCCGAGGCCGCGGCCGAGGAAAAGCAACTGGCGGCAGCAGCGGCGGCGGCG 
               
               
                   
               
               
                 GCGTTGGCCGCGGCGGAGGCTGAGTCTGAGGGGACCAAGCCCGCCAAGGAGCCCGTGATTAAGCCC 
               
               
                   
               
               
                 CTGACCGAAGATAGCAAGAAGCGCAGTTACAACCTGCTCAAGGACAGCACCAACACCGCGTACCGC 
               
               
                   
               
               
                 AGCTGGTACCTGGCCTACAACTACGGCGACCCGTCGACGGGGGTGCGCTCCTGGACCCTGCTGTGCA 
               
               
                   
               
               
                 CGCCGGACGTGACCTGCGGCTCGGAGCAGGTGTACTGGTCGCTGCCCGACATGATGCAAGACCCCGT 
               
               
                   
               
               
                 GACCTTCCGCTCCACGCGGCAGGTCAGCAACTTCCCGGTGGTGGGCGCCGAGCTGCTGCCCGTGCAC 
               
               
                   
               
               
                 TCCAAGAGCTTCTACAACGACCAGGCCGTCTACTCCCAGCTCATCCGCCAGTTCACCTCTCTGACCCA 
               
               
                   
               
               
                 CGTGTTCAATCGCTTTCCTGAGAACCAGATTCTGGCGCGCCCGCCCGCCCCCACCATCACCACCGTCA 
               
               
                   
               
               
                 GTGAAAACGTTCCTGCTCTCACAGATCACGGGACGCTACCGCTGCGCAACAGCATCGGAGGAGTCCA 
               
               
                   
               
               
                 GCGAGTGACCGTTACTGACGCCAGACGCCGCACCTGCCCCTACGTTTACAAGGCCTTGGGCATAGTC 
               
               
                   
               
               
                 TCGCCGCGCGTCCTTTCCAGCCGCACTTTTTGAGCAACACCACCATCATGTCCATCCTGATCTCACCC 
               
               
                   
               
               
                 AGCAATAACTCCGGCTGGGGACTGCTGCGCGCGCCCAGCAAGATGTTCGGAGGGGCGAGGAAGCGT 
               
               
                   
               
               
                 TCCGAGCAGCACCCCGTGCGCGTGCGCGGGCACTTCCGCGCCCCCTGGGGAGCGCACAAACGCGGCC 
               
               
                   
               
               
                 GCGCGGGGCGCACCACCGTGGACGACGCCATCGACTCGGTGGTGGAGCAGGCGCGCAACTACAGGC 
               
               
                   
               
               
                 CCGCGGTCTCTACCGTGGACGCGGCCATCCAGACCGTGGTGCGGGGCGCGCGGCGGTACGCCAAGCT 
               
               
                   
               
               
                 GAAGAGCCGCCGGAAGCGCGTGGCCCGCCGCCACCGCCGCCGACCCGGGGCCGCCGCCAAACGCGC 
               
               
                   
               
               
                 CGCCGCGGCCCTGCTTCGCCGGGCCAAGCGCACGGGCCGCCGCGCCGCCATGAGGGCCGCGCGCCGC 
               
               
                   
               
               
                 TTGGCCGCCGGCATCACCGCCGCCACCATGGCCCCCCGTACCCGAAGACGCGCGGCCGCCGCCGCCG 
               
               
                   
               
               
                 CCGCCGCCATCAGTGACATGGCCAGCAGGCGCCGGGGCAACGTGTACTGGGTGCGCGACTCGGTGAC 
               
               
                   
               
               
                 CGGCACGCGCGTGCCCGTGCGCTTCCGCCCCCCGCGGACTTGAGATGATGTGAAAAAACAACACTGA 
               
               
                   
               
               
                 GTCTCCTGCTGTTGTGTGTATCCCAGCGGCGGCGGCGCGCGCAGCGTCATGTCCAAGCGCAAAATCA 
               
               
                   
               
               
                 AAGAAGAGATGCTCCAGGTCGTCGCGCCGGAGATCTATGGGCCCCCGAAGAAGGAAGAGCAGGATT 
               
               
                   
               
               
                 CGAAGCCCCGCAAGATAAAGCGGGTCAAAAAGAAAAAGAAAGATGATGACGATGCCGATGGGGAG 
               
               
                   
               
               
                 GTGGAGTTCCTGCGCGCCACGGCGCCCAGGCGCCCGGTGCAGTGGAAGGGCCGGCGCGTAAAGCGC 
               
               
                   
               
               
                 GTCCTGCGCCCCGGCACCGCGGTGGTCTTCACGCCCGGCGAGCGCTCCACCCGGACTTTCAAGCGCG 
               
               
                   
               
               
                 TCTATGACGAGGTGTACGGCGACGAAGACCTGCTGGAGCAGGCCAACGAGCGCTTCGGAGAGTTTGC 
               
               
                   
               
               
                 TTACGGGAAGCGTCAGCGGGCGCTGGGGAAGGAGGACCTGCTGGCGCTGCCGCTGGACCAGGGCAA 
               
               
                   
               
               
                 CCCCACCCCCAGTCTGAAGCCCGTGACCCTGCAGCAGGTGCTGCCGAGCAGCGCACCCTCCGAGGCG 
               
               
                   
               
               
                 AAGCGGGGTCTGAAGCGCGAGGGCGGCGACCTGGCGCCCACCGTGCAGCTCATGGTGCCCAAGCGG 
               
               
                   
               
               
                 CAGAGGCTGGAGGATGTGCTGGAGAAAATGAAAGTAGACCCCGGTCTGCAGCCGGACATCAGGGTC 
               
               
                   
               
               
                 CGCCCCATCAAGCAGGTGGCGCCGGGCCTCGGCGTGCAGACCGTGGACGTGGTCATCCCCACCGGCA 
               
               
                   
               
               
                 ACTCCCCCGCCGCCGCCACCACTACCGCTGCCTCCACGGACATGGAGACACAGACCGATCCCGCCGC 
               
               
                   
               
               
                 AGCCGCAGCCGCAGCCGCCGCCGCGACCTCCTCGGCGGAGGTGCAGACGGACCCCTGGCTGCCGCCG 
               
               
                   
               
               
                 GCGATGTCAGCTCCCCGCGCGCGTCGCGGGCGCAGGAAGTACGGCGCCGCCAACGCGCTCCTGCCCG 
               
               
                   
               
               
                 AGTACGCCTTGCATCCTTCCATCGCGCCCACCCCCGGCTACCGAGGCTATACCTACCGCCCGCGAAG 
               
               
                   
               
               
                 AGCCAAGGGTTCCACCCGCCGTCCCCGCCGACGCGCCGCCGCCACCACCCGCCGCCGCCGCCGCAGA 
               
               
                   
               
               
                 CGCCAGCCCGCACTGGCTCCAGTCTCCGTGAGGAAAGTGGCGCGCGACGGACACACCCTGGTGCTGC 
               
               
                   
               
               
                 CCAGGGCGCGCTACCACCCCAGCATCGTTTAAAAGCCTGTTGTGGTTCTTGCAGATATGGCCCTCACT 
               
               
                   
               
               
                 TGCCGCCTCCGTTTCCCGGTGCCGGGATACCGAGGAGGAAGATCGCGCCGCAGGAGGGGTCTGGCCG 
               
               
                   
               
               
                 GCCGCGGCCTGAGCGGAGGCAGCCGCCGCGCGCACCGGCGGCGACGCGCCACCAGCCGACGCATGC 
               
               
                   
               
               
                 GCGGCGGGGTGCTGCCCCTGTTAATCCCCCTGATCGCCGCGGCGATCGGCGCCGTGCCCGGGATCGC 
               
               
                   
               
               
                 CTCCGTGGCCTTGCAAGCGTCCCAGAGGCATTGACAGACTTGCAAACTTGCAAATATGGAAAAAAAA 
               
               
                   
               
               
                 ACCCCAATAAAAAAGTCTAGACTCTCACGCTCGCTTGGTCCTGTGACTATTTTGTAGAATGGAAGAC 
               
               
                   
               
               
                 ATCAACTTTGCGTCGCTGGCCCCGCGTCACGGCTCGCGCCCGTTCCTGGGACACTGGAACGATATCG 
               
               
                   
               
               
                 GCACCAGCAACATGAGCGGTGGCGCCTTCAGTTGGGGCTCTCTGTGGAGCGGCATTAAAAGTATCGG 
               
               
                   
               
               
                 GTCTGCCGTTAAAAATTACGGCTCCCGGGCCTGGAACAGCAGCACGGGCCAGATGTTGAGAGACAA 
               
               
                   
               
               
                 GTTGAAAGAGCAGAACTTCCAGCAGAAGGTGGTGGAGGGCCTGGCCTCCGGCATCAACGGGGTGGT 
               
               
                   
               
               
                 GGACCTGGCCAACCAGGCCGTGCAGAATAAGATCAACAGCAGACTGGACCCCCGGCCGCCGGTGGA 
               
               
                   
               
               
                 GGAGGTGCCGCCGGCGCTGGAGACGGTGTCCCCCGATGGGCGTGGCGAGAAGCGCCCGCGGCCCGA 
               
               
                   
               
               
                 TAGGGAAGAGACCACTCTGGTCACGCAGACCGATGAGCCGCCCCCGTATGAGGAGGCCCTGAAGCA 
               
               
                   
               
               
                 AGGTCTGCCCACCACGCGGCCCATCGCGCCCATGGCCACCGGGGTGGTGGGCCGCCACACCCCCGCC 
               
               
                   
               
               
                 ACGCTGGACTTGCCTCCGCCCGCCGATGTGCCGCAGCAGCAGAAGGCGGCACAGCCGGGCCCGCCCG 
               
               
                   
               
               
                 CGACCGCCTCCCGTTCCTCCGCCGGTCCTCTGCGCCGCGCGGCCAGCGGCCCCCGCGGGGGGGTCGC 
               
               
                   
               
               
                 GAGGCACGGCAACTGGCAGAGCACGCTGAACAGCATCGTGGGTCTGGGGGTGCGGTCCGTGAAGCG 
               
               
                   
               
               
                 CCGCCGATGCTACTGAATAGCTTAGCTAACGTGTTGTATGTGTGTATGCGCCCTATGTCGCCGCCAGA 
               
               
                   
               
               
                 GGAGCTGCTGAGTCGCCGCCGTTCGCGCGCCCACCACCACCGCCACTCCGCCCCTCAAGATGGCGAC 
               
               
                   
               
               
                 CCCATCGATGATGCCGCAGTGGTCGTACATGCACATCTCGGGCCAGGACGCCTCGGAGTACCTGAGC 
               
               
                   
               
               
                 CCCGGGCTGGTGCAGTTCGCCCGCGCCACCGAGAGCTACTTCAGCCTGAGTAACAAGTTTAGGAACC 
               
               
                   
               
               
                 CCACGGTGGCGCCCACGCACGATGTGACCACCGACCGGTCTCAGCGCCTGACGCTGCGGTTCATTCC 
               
               
                   
               
               
                 CGTGGACCGCGAGGACACCGCGTACTCGTACAAGGCGCGGTTCACCCTGGCCGTGGGCGACAACCGC 
               
               
                   
               
               
                 GTGCTGGACATGGCCTCCACCTACTTTGACATCCGCGGGGTGCTGGACCGGGGTCCCACTTTCAAGCC 
               
               
                   
               
               
                 CTACTCTGGCACCGCCTACAACTCCCTGGCCCCCAAGGGCGCTCCCAACTCCTGCGAGTGGGAGCAA 
               
               
                   
               
               
                 GAGGAAACTCAGGCAGTTGAAGAAGCAGCAGAAGAGGAAGAAGAAGATGCTGACGGTCAAGCTGA 
               
               
                   
               
               
                 GGAAGAGCAAGCAGCTACCAAAAAGACTCATGTATATGCTCAGGCTCCCCTTTCTGGCGAAAAAATT 
               
               
                   
               
               
                 AGTAAAGATGGTCTGCAAATAGGAACGGACGCTACAGCTACAGAACAAAAACCTATTTATGCAGAC 
               
               
                   
               
               
                 CCTACATTCCAGCCCGAACCCCAAATCGGGGAGTCCCAGTGGAATGAGGCAGATGCTACAGTCGCCG 
               
               
                   
               
               
                 GCGGTAGAGTGCTAAAGAAATCTACTCCCATGAAACCATGCTATGGTTCCTATGCAAGACCCACAAA 
               
               
                   
               
               
                 TGCTAATGGAGGTCAGGGTGTACTAACGGCAAATGCCCAGGGACAGCTAGAATCTCAGGTTGAAATG 
               
               
                   
               
               
                 CAATTCTTTTCAACTTCTGAAAACGCCCGTAACGAGGCTAACAACATTCAGCCCAAATTGGTGCTGTA 
               
               
                   
               
               
                 TAGTGAGGATGTGCACATGGAGACCCCGGATACGCACCTTTCTTACAAGCCCGCAAAAAGCGATGAC 
               
               
                   
               
               
                 AATTCAAAAATCATGCTGGGTCAGCAGTCCATGCCCAACAGACCTAATTACATCGGCTTCAGAGACA 
               
               
                   
               
               
                 ACTTTATCGGCCTCATGTATTACAATAGCACTGGCAACATGGGAGTGCTTGCAGGTCAGGCCTCTCAG 
               
               
                   
               
               
                 TTGAATGCAGTGGTGGACTTGCAAGACAGAAACACAGAACTGTCCTACCAGCTCTTGCTTGATTCCA 
               
               
                   
               
               
                 TGGGTGACAGAACCAGATACTTTTCCATGTGGAATCAGGCAGTGGACAGTTATGACCCAGATGTTAG 
               
               
                   
               
               
                 AATTATTGAAAATCATGGAACTGAAGACGAGCTCCCCAACTATTGTTTCCCTCTGGGTGGCATAGGG 
               
               
                   
               
               
                 GTAACTGACACTTACCAGGCTGTTAAAACCAACAATGGCAATAACGGGGGCCAGGTGACTTGGACA 
               
               
                   
               
               
                 AAAGATGAAACTTTTGCAGATCGCAATGAAATAGGGGTGGGAAACAATTTCGCTATGGAGATCAACC 
               
               
                   
               
               
                 TCAGTGCCAACCTGTGGAGAAACTTCCTGTACTCCAACGTGGCGCTGTACCTACCAGACAAGCTTAA 
               
               
                   
               
               
                 GTACAACCCCTCCAATGTGGACATCTCTGACAACCCCAACACCTACGATTACATGAACAAGCGAGTG 
               
               
                   
               
               
                 GTGGCCCCGGGGCTGGTGGACTGCTACATCAACCTGGGCGCGCGCTGGTCGCTGGACTACATGGACA 
               
               
                   
               
               
                 ACGTCAACCCCTTCAACCACCACCGCAATGCGGGCCTGCGCTACCGCTCCATGCTCCTGGGCAACGG 
               
               
                   
               
               
                 GCGCTACGTGCCCTTCCACATCCAGGTGCCCCAGAAGTTCTTTGCCATCAAGAACCTCCTCCTCCTGC 
               
               
                   
               
               
                 CGGGCTCCTACACCTACGAGTGGAACTTCAGGAAGGATGTCAACATGGTCCTCCAGAGCTCTCTGGG 
               
               
                   
               
               
                 TAACGATCTCAGGGTGGACGGGGCCAGCATCAAGTTCGAGAGCATCTGCCTCTACGCCACCTTCTTC 
               
               
                   
               
               
                 CCCATGGCCCACAACACGGCCTCCACGCTCGAGGCCATGCTCAGGAACGACACCAACGACCAGTCCT 
               
               
                   
               
               
                 TCAATGACTACCTCTCCGCCGCCAACATGCTCTACCCCATACCCGCCAACGCCACCAACGTCCCCATC 
               
               
                   
               
               
                 TCCATCCCCTCGCGCAACTGGGCGGCCTTCCGCGGCTGGGCCTTCACCCGCCTCAAGACCAAGGAGA 
               
               
                   
               
               
                 CCCCCTCCCTGGGCTCGGGATTCGACCCCTACTACACCTACTCGGGCTCCATTCCCTACCTGGACGGC 
               
               
                   
               
               
                 ACCTTCTACCTCAACCACACTTTCAAGAAGGTCTCGGTCACCTTCGACTCCTCGGTCAGCTGGCCGGG 
               
               
                   
               
               
                 CAACGACCGTCTGCTCACCCCCAACGAGTTCGAGATCAAGCGCTCGGTCGACGGGGAGGGCTACAAC 
               
               
                   
               
               
                 GTGGCCCAGTGCAACATGACCAAGGACTGGTTCCTGGTCCAGATGCTGGCCAACTACAACATCGGCT 
               
               
                   
               
               
                 ACCAGGGCTTCTACATCCCAGAGAGCTACAAGGACAGGATGTACTCCTTCTTCAGGAACTTCCAGCC 
               
               
                   
               
               
                 CATGAGCCGGCAGGTGGTGGACCAGACCAAGTACAAGGACTACCAGGAGGTGGGCATCATCCACCA 
               
               
                   
               
               
                 GCACAACAACTCGGGCTTCGTGGGCTACCTCGCCCCCACCATGCGCGAGGGACAGGCCTACCCCGCC 
               
               
                   
               
               
                 AACTTCCCCTATCCGCTCATAGGCAAGACCGCGGTCGACAGCATCACCCAGAAAAAGTTCCTCTGCG 
               
               
                   
               
               
                 ACCGCACCCTCTGGCGCATCCCCTTCTCCAGCAACTTCATGTCCATGGGTGCGCTCTCGGACCTGGGC 
               
               
                   
               
               
                 CAGAACTTGCTCTACGCCAACTCCGCCCACGCCCTCGACATGACCTTCGAGGTCGACCCCATGGACG 
               
               
                   
               
               
                 AGCCCACCCTTCTCTATGTTCTGTTCGAAGTCTTTGACGTGGTCCGGGTCCACCAGCCGCACCGCGGC 
               
               
                   
               
               
                 GTCATCGAGACCGTGTACCTGCGTACGCCCTTCTCGGCCGGCAACGCCACCACCTAAAGAAGCAAGC 
               
               
                   
               
               
                 CGCAGTCATCGCCGCCTGCATGCCGTCGGGTTCCACCGAGCAAGAGCTCAGGGCCATCGTCAGAGAC 
               
               
                   
               
               
                 CTGGGATGCGGGCCCTATTTTTTGGGCACCTTCGACAAGCGCTTCCCTGGCTTTGTCTCCCCACACAA 
               
               
                   
               
               
                 GCTGGCCTGCGCCATCGTCAACACGGCCGGCCGCGAGACCGGGGGCGTGCACTGGCTGGCCTTCGCC 
               
               
                   
               
               
                 TGGAACCCGCGCTCCAAAACATGCTTCCTCTTTGACCCCTTCGGCTTTTCGGACCAGCGGCTCAAGCA 
               
               
                   
               
               
                 AATCTACGAGTTCGAGTACGAGGGCTTGCTGCGTCGCAGCGCCATCGCCTCCTCGCCCGACCGCTGC 
               
               
                   
               
               
                 GTCACCCTCGAAAAGTCCACCCAGACCGTGCAGGGGCCCGACTCGGCCGCCTGCGGTCTCTTCTGCT 
               
               
                   
               
               
                 GCATGTTTCTGCACGCCTTTGTGCACTGGCCTCAGAGTCCCATGGACCGCAACCCCACCATGAACTTG 
               
               
                   
               
               
                 CTGACGGGGGTGCCCAACTCCATGCTCCAGAGCCCCCAGGTCGAGCCCACCCTGCGCCGCAACCAGG 
               
               
                   
               
               
                 AGCAGCTCTACAGCTTCCTGGAGCGCCACTCGCCTTACTTCCGCCGCCACAGCGCACAGATCAGGAG 
               
               
                   
               
               
                 GGCCACCTCCTTCTGCCACTTGCAAGAGATGCAAGAAGGGTAATAACGATGTACACACTTTTTTTCTC 
               
               
                   
               
               
                 AATAAATGGCATCTTTTTATTTATACAAGCTCTCTGGGGTATTCATTTCCCACCACCACCCGCCGTTGT 
               
               
                   
               
               
                 CGCCATCTGGCTCTATTTAGAAATCGAAAGGGTTCTGCCGGGAGTCGCCGTGCGCCACGGGCAGGGA 
               
               
                   
               
               
                 CACGTTGCGATACTGGTAGCGGGTGCCCCACTTGAACTCGGGCACCACCAGGCGAGGCAGCTCGGGG 
               
               
                   
               
               
                 AAGTTTTCGCTCCACAGGCTGCGGGTCAGCACCAGCGCGTTCATCAGGTCGGGCGCCGAGATCTTGA 
               
               
                   
               
               
                 AGTCGCAGTTGGGGCCGCCGCCCTGCGCGCGCGAGTTGCGGTACACCGGGTTGCAGCACTGGAACAC 
               
               
                   
               
               
                 CAACAGCGCCGGGTGCTTCACGCTGGCCAGCACGCTGCGGTCGGAGATCAGCTCGGCGTCCAGGTCC 
               
               
                   
               
               
                 TCCGCGTTGCTCAGCGCGAACGGGGTCATCTTGGGCACTTGCCGCCCCAGGAAGGGCGCGTGCCCCG 
               
               
                   
               
               
                 GTTTCGAGTTGCAGTCGCAGCGCAGCGGGATCAGCAGGTGCCCGTGCCCGGACTCGGCGTTGGGGTA 
               
               
                   
               
               
                 CAGCGCGCGCATGAAGGCCTGCATCTGGCGGAAGGCCATCTGGGCCTTGGCGCCCTCCGAGAAGAAC 
               
               
                   
               
               
                 ATGCCGCAGGACTTGCCCGAGAACTGGTTTGCGGGGCAGCTGGCGTCGTGCAGGCAGCAGCGCGCGT 
               
               
                   
               
               
                 CGGTGTTGGCGATCTGCACCACGTTGCGCCCCCACCGGTTCTTCACGATCTTGGCCTTGGACGATTGC 
               
               
                   
               
               
                 TCCTTCAGCGCGCGCTGCCCGTTCTCGCTGGTCACATCCATCTCGATCACATGTTCCTTGTTCACCATG 
               
               
                   
               
               
                 CTGCTGCCGTGCAGACACTTCAGCTCGCCCTCCGTCTCGGTGCAGCGGTGCTGCCACAGCGCGCAGC 
               
               
                   
               
               
                 CCGTGGGCTCGAAAGACTTGTAGGTCACCTCCGCGAAGGACTGCAGGTACCCCTGCAAAAAGCGGCC 
               
               
                   
               
               
                 CATCATGGTCACGAAGGTCTTGTTGCTGCTGAAGGTCAGCTGCAGCCCGCGGTGCTCCTCGTTCAGCC 
               
               
                   
               
               
                 AGGTCTTGCACACGGCCGCCAGCGCCTCCACCTGGTCGGGCAGCATCTTGAAGTTCACCTTCAGCTCA 
               
               
                   
               
               
                 TTCTCCACGTGGTACTTGTCCATCAGCGTGCGCGCCGCCTCCATGCCCTTCTCCCAGGCCGACACCAG 
               
               
                   
               
               
                 CGGCAGGCTCACGGGGTTCTTCACCATCACCGTGGCCGCCGCCTCCGCCGCGCTTTCGCTTTCCGCCC 
               
               
                   
               
               
                 CGCTGTTCTCTTCCTCTTCCTCCTCTTCCTCGCCGCCGCCCACTCGCAGCCCCCGCACCACGGGGTCGT 
               
               
                   
               
               
                 CTTCCTGCAGGCGCTGCACCTTGCGCTTGCCGTTGCGCCCCTGCTTGATGCGCACGGGCGGGTTGCTG 
               
               
                   
               
               
                 AAGCCCACCATCACCAGCGCGGCCTCTTCTTGCTCGTCCTCGCTGTCCAGAATGACCTCCGGGGAGG 
               
               
                   
               
               
                 GGGGGTTGGTCATCCTCAGTACCGAGGCACGCTTCTTTTTCTTCCTGGGGGCGTTCGCCAGCTCCGCG 
               
               
                   
               
               
                 GCTGCGGCCGCTGCCGAGGTCGAAGGCCGAGGGCTGGGCGTGCGCGGCACCAGCGCGTCCTGCGAG 
               
               
                   
               
               
                 CCGTCCTCGTCCTCCTCGGACTCGAGACGGAGGCGGGCCCGCTTCTTCGGGGGCGCGCGGGGCGGCG 
               
               
                   
               
               
                 GAGGCGGCGGCGGCGACGGAGACGGGGACGAGACATCGTCCAGGGTGGGTGGACGGCGGGCCGCG 
               
               
                   
               
               
                 CCGCGTCCGCGCTCGGGGGTGGTCTCGCGCTGGTCCTCTTCCCGACTGGCCATCTCCCACTGCTCCTT 
               
               
                   
               
               
                 CTCCTATAGGCAGAAAGAGATCATGGAGTCTCTCATGCGAGTCGAGAAGGAGGAGGACAGCCTAAC 
               
               
                   
               
               
                 CGCCCCCTCTGAGCCCTCCACCACCGCCGCCACCACCGCCAATGCCGCCGCGGACGACGCGCCCACC 
               
               
                   
               
               
                 GAGACCACCGCCAGTACCACCCTCCCCAGCGACGCACCCCCGCTCGAGAATGAAGTGCTGATCGAGC 
               
               
                   
               
               
                 AGGACCCGGGTTTTGTGAGCGGAGAGGAGGATGAGGTGGATGAGAAGGAGAAGGAGGAGGTCGCC 
               
               
                   
               
               
                 GCCTCAGTGCCAAAAGAGGATAAAAAGCAAGACCAGGACGACGCAGATAAGGATGAGACAGCAGT 
               
               
                   
               
               
                 CGGGCGGGGGAACGGAAGCCATGATGCTGATGACGGCTACCTAGACGTGGGAGACGACGTGCTGCT 
               
               
                   
               
               
                 TAAGCACCTGCACCGCCAGTGCGTCATCGTCTGCGACGCGCTGCAGGAGCGCTGCGAAGTGCCCCTG 
               
               
                   
               
               
                 GACGTGGCGGAGGTCAGCCGCGCCTACGAGCGGCACCTCTTCGCGCCGCACGTGCCCCCCAAGCGCC 
               
               
                   
               
               
                 GGGAGAACGGCACCTGCGAGCCCAACCCGCGTCTCAACTTCTACCCGGTCTTCGCGGTACCCGAGGT 
               
               
                   
               
               
                 GCTGGCCACCTACCACATCTTTTTCCAAAACTGCAAGATCCCCCTCTCCTGCCGCGCCAACCGCACCC 
               
               
                   
               
               
                 GCGCCGACAAAACCCTGACCCTGCGGCAGGGCGCCCACATACCTGATATCGCCTCTCTGGAGGAAGT 
               
               
                   
               
               
                 GCCCAAGATCTTCGAGGGTCTCGGTCGCGACGAGAAACGGGCGGCGAACGCTCTGCACGGAGACAG 
               
               
                   
               
               
                 CGAAAACGAGAGTCACTCGGGGGTGCTGGTGGAGCTCGAGGGCGACAACGCGCGCCTGGCCGTACT 
               
               
                   
               
               
                 CAAGCGCAGCATAGAGGTCACCCACTTTGCCTACCCGGCGCTCAACCTGCCCCCCAAGGTCATGAGT 
               
               
                   
               
               
                 GTGGTCATGGGCGAGCTCATCATGCGCCGCGCCCAGCCCCTGGCCGCGGATGCAAACTTGCAAGAGT 
               
               
                   
               
               
                 CCTCCGAGGAAGGCCTGCCCGCGGTCAGCGACGAGCAGCTGGCGCGCTGGCTGGAGACCCGCGACC 
               
               
                   
               
               
                 CCGCGCAGCTGGAGGAGCGGCGCAAGCTCATGATGGCCGCGGTGCTGGTCACCGTGGAGCTCGAGT 
               
               
                   
               
               
                 GTCTGCAGCGCTTCTTCGCGGACCCCGAGATGCAGCGCAAGCTCGAGGAGACCCTGCACTACACCTT 
               
               
                   
               
               
                 CCGCCAGGGCTACGTGCGCCAGGCCTGCAAGATCTCCAACGTGGAGCTCTGCAACCTGGTCTCCTAC 
               
               
                   
               
               
                 CTGGGCATCCTGCACGAGAACCGCCTCGGGCAGAACGTCCTGCACTCCACCCTCAAAGGGGAGGCGC 
               
               
                   
               
               
                 GCCGCGACTACATCCGCGACTGCGCCTACCTCTTCCTCTGCTACACCTGGCAGACGGCCATGGGGGTC 
               
               
                   
               
               
                 TGGCAGCAGTGCCTGGAGGAGCGCAACCTCAAGGAGCTGGAAAAGCTCCTCAAGCGCACCCTCAGG 
               
               
                   
               
               
                 GACCTCTGGACGGGCTTCAACGAGCGCTCGGTGGCCGCCGCGCTGGCGGACATCATCTTTCCCGAGC 
               
               
                   
               
               
                 GCCTGCTCAAGACCCTGCAGCAGGGCCTGCCCGACTTCACCAGCCAGAGCATGCTGCAGAACTTCAG 
               
               
                   
               
               
                 GACTTTCATCCTGGAGCGCTCGGGCATCCTGCCGGCCACTTGCTGCGCGCTGCCCAGCGACTTCGTGC 
               
               
                   
               
               
                 CCATCAAGTACAGGGAGTGCCCGCCGCCGCTCTGGGGCCACTGCTACCTCTTCCAGCTGGCCAACTA 
               
               
                   
               
               
                 CCTCGCCTACCACTCGGACCTCATGGAAGACGTGAGCGGCGAGGGCCTGCTCGAGTGCCACTGCCGC 
               
               
                   
               
               
                 TGCAACCTCTGCACGCCCCACCGCTCTCTAGTCTGCAACCCGCAGCTGCTCAGCGAGAGTCAGATTAT 
               
               
                   
               
               
                 CGGTACCTTCGAGCTGCAGGGTCCCTCGCCTGACGAGAAGTCCGCGGCTCCAGGGCTGAAACTCACT 
               
               
                   
               
               
                 CCGGGGCTGTGGACTTCCGCCTACCTACGCAAATTTGTACCTGAGGACTACCACGCCCACGAGATCA 
               
               
                   
               
               
                 GGTTCTACGAAGACCAATCCCGCCCGCCCAAGGCGGAGCTCACCGCCTGCGTCATCACCCAGGGGCA 
               
               
                   
               
               
                 CATCCTGGGCCAATTGCAAGCCATCAACAAAGCCCGCCGAGAGTTCTTGCTGAAAAAGGGTCGGGGG 
               
               
                   
               
               
                 GTGTACCTGGACCCCCAGTCCGGCGAGGAGCTAAACCCGCTACCCCCGCCGCCGCCCCAGCAGCGGG 
               
               
                   
               
               
                 ACCTTGCTTCCCAGGATGGCACCCAGAAAGAAGCAGCAGCCGCCGCCGCCGCCGCAGCCATACATGC 
               
               
                   
               
               
                 TTCTGGAGGAAGAGGAGGAGGACTGGGACAGTCAGGCAGAGGAGGTTTCGGACGAGGAGCAGGAG 
               
               
                   
               
               
                 GAGATGATGGAAGACTGGGAGGAGGACAGCAGCCTAGACGAGGAAGCTTCAGAGGCCGAAGAGGT 
               
               
                   
               
               
                 GGCAGACGCAACACCATCGCCCTCGGTCGCAGCCCCCTCGCCGGGGCCCCTGAAATCCTCCGAACCC 
               
               
                   
               
               
                 AGCACCAGCGCTATAACCTCCGCTCCTCCGGCGCCGGCGCCACCCGCCCGCAGACCCAACCGTAGAT 
               
               
                   
               
               
                 GGGACACCACAGGAACCGGGGTCGGTAAGTCCAAGTGCCCGCCGCCGCCACCGCAGCAGCAGCAGC 
               
               
                   
               
               
                 AGCAGCGCCAGGGCTACCGCTCGTGGCGCGGGCACAAGAACGCCATAGTCGCCTGCTTGCAAGACTG 
               
               
                   
               
               
                 CGGGGGCAACATCTCTTTCGCCCGCCGCTTCCTGCTATTCCACCACGGGGTCGCCTTTCCCCGCAATG 
               
               
                   
               
               
                 TCCTGCATTACTACCGTCATCTCTACAGCCCCTACTGCAGCGGCGACCCAGAGGCGGCAGCGGCAGC 
               
               
                   
               
               
                 CACAGCGGCGACCACCACCTAGGAAGATATCCTCCGCGGGCAAGACAGCGGCAGCAGCGGCCAGGA 
               
               
                   
               
               
                 GACCCGCGGCAGCAGCGGCGGGAGCGGTGGGCGCACTGCGCCTCTCGCCCAACGAACCCCTCTCGAC 
               
               
                   
               
               
                 CCGGGAGCTCAGACACAGGATCTTCCCCACTTTGTATGCCATCTTCCAACAGAGCAGAGGCCAGGAG 
               
               
                   
               
               
                 CAGGAGCTGAAAATAAAAAACAGATCTCTGCGCTCCCTCACCCGCAGCTGTCTGTATCACAAAAGCG 
               
               
                   
               
               
                 AAGATCAGCTTCGGCGCACGCTGGAGGACGCGGAGGCACTCTTCAGCAAATACTGCGCGCTCACTCT 
               
               
                   
               
               
                 TAAAGACTAGCTCCGCGCCCTTCTCGAATTTAGGCGGGAGAAAACTACGTCATCGCCGGCCGCCGCC 
               
               
                   
               
               
                 CAGCCCGCCCAGCCGAGATGAGCAAAGAGATTCCCACGCCATACATGTGGAGCTACCAGCCGCAGA 
               
               
                   
               
               
                 TGGGACTCGCGGCGGGAGCGGCCCAGGACTACTCCACCCGCATGAACTACATGAGCGCGGGACCCC 
               
               
                   
               
               
                 ACATGATCTCACAGGTCAACGGGATCCGCGCCCAGCGAAACCAAATACTGCTGGAACAGGCGGCCA 
               
               
                   
               
               
                 TCACCGCCACGCCCCGCCATAATCTCAACCCCCGAAATTGGCCCGCCGCCCTCGTGTACCAGGAAAC 
               
               
                   
               
               
                 CCCCTCCGCCACCACCGTACTACTTCCGCGTGACGCCCAGGCCGAAGTCCAGATGACTAACTCAGGG 
               
               
                   
               
               
                 GCGCAGCTCGCGGGCGGCTTTCGTCACGGGGCGCGGCCGCTCCGACCAGGTATAAGACACCTGATGA 
               
               
                   
               
               
                 TCAGAGGCCGAGGTATCCAGCTCAACGACGAGTCGGTGAGCTCTTCGCTCGGTCTCCGTCCGGACGG 
               
               
                   
               
               
                 AACTTTCCAGCTCGCCGGATCCGGCCGCTCTTCGTTCACGCCCCGCCAGGCGTACCTGACTCTGCAGA 
               
               
                   
               
               
                 CCTCGTCCTCGGAGCCCCGCTCCGGCGGCATCGGAACCCTCCAGTTCGTGGAGGAGTTCGTGCCCTCG 
               
               
                   
               
               
                 GTCTACTTCAACCCCTTCTCGGGACCTCCCGGACGCTACCCCGACCAGTTCATTCCGAACTTTGACGC 
               
               
                   
               
               
                 GGTGAAGGACTCGGCGGACGGCTACGACTGAATGTCAGGTGTCGAGGCAGAGCAGCTTCGCCTGAG 
               
               
                   
               
               
                 ACACCTCGAGCACTGCCGCCGCCACAAGTGCTTCGCCCGCGGTTCTGGTGAGTTCTGCTACTTTCAGC 
               
               
                   
               
               
                 TACCCGAGGAGCATACCGAGGGGCCGGCGCACGGCGTCCGCCTGACCACCCAGGGCGAGGTTACCT 
               
               
                   
               
               
                 GTTCCCTCATCCGGGAGTTTACCCTCCGTCCCCTGCTAGTGGAGCGGGAGCGGGGTCCCTGTGTCCTA 
               
               
                   
               
               
                 ACTATCGCCTGCAACTGCCCTAACCCTGGATTACATCAAGATCTTTGCTGTCATCTCTGTGCTGAGTTT 
               
               
                   
               
               
                 AATAAACGCTGAGATCAGAATCTACTGGGGCTCCTGTCGCCATCCTGTGAACGCCACCGTCTTCACCC 
               
               
                   
               
               
                 ACCCCGACCAGGCCCAGGCGAACCTCACCTGCGGTCTGCATCGGAGGGCCAAGAAGTACCTCACCTG 
               
               
                   
               
               
                 GTACTTCAACGGCACCCCCTTTGTGGTTTACAACAGCTTCGACGGGGACGGAGTCTCCCTGAAAGAC 
               
               
                   
               
               
                 CAGCTCTCCGGTCTCAGCTACTCCATCCACAAGAACACCACCCTCCAACTCTTCCCTCCCTACCTGCC 
               
               
                   
               
               
                 GGGAACCTACGAGTGCGTCACCGGCCGCTGCACCCACCTCACCCGCCTGATCGTAAACCAGAGCTTT 
               
               
                   
               
               
                 CCGGGAACAGATAACTCCCTCTTCCCCAGAACAGGAGGTGAGCTCAGGAAACTCCCCGGGGACCAG 
               
               
                   
               
               
                 GGCGGAGACGTACCTTCGACCCTTGTGGGGTTAGGATTTTTTATTACCGGGTTGCTGGCTCTTTTAAT 
               
               
                   
               
               
                 CAAAGTTTCCTTGAGATTTGTTCTTTCCTTCTACGTGTATGAACACCTCAACCTCCAATAACTCTACCC 
               
               
                   
               
               
                 TTTCTTCGGAATCAGGTGACTTCTCTGAAATCGGGCTTGGTGTGCTGCTTACTCTGTTGATTTTTTTCC 
               
               
                   
               
               
                 TTATCATACTCAGCCTTCTGTGCCTCAGGCTCGCCGCCTGCTGCGCACACATCTATATCTACTGCTGGT 
               
               
                   
               
               
                 TGCTCAAGTGCAGGGGTCGCCACCCAAGATGAACAGGTACATGGTCCTATCGATCCTAGGCCTGCTG 
               
               
                   
               
               
                 GCCCTGGCGGCCTGCAGCGCCGCCAAAAAAGAGATTACCTTTGAGGAGCCCGCTTGCAATGTAACTT 
               
               
                   
               
               
                 TCAAGCCCGAGGGTGACCAATGCACCACCCTCGTCAAATGCGTTACCAATCATGAGAGGCTGCGCAT 
               
               
                   
               
               
                 CGACTACAAAAACAAAACTGGCCAGTTTGCGGTCTATAGTGTGTTTACGCCCGGAGACCCCTCTAAC 
               
               
                   
               
               
                 TACTCTGTCACCGTCTTCCAGGGCGGACAGTCTAAGATATTCAATTACACTTTCCCTTTTTATGAGTTA 
               
               
                   
               
               
                 TGCGATGCGGTCATGTACATGTCAAAACAGTACAACCTGTGGCCTCCCTCTCCCCAGGCGTGTGTGG 
               
               
                   
               
               
                 AAAATACTGGGTCTTACTGCTGTATGGCTTTCGCAATCACTACGCTCGCTCTAATCTGCACGGTGCTA 
               
               
                   
               
               
                 TACATAAAATTCAGGCAGAGGCGAATCTTTATCGATGAAAAGAAAATGCCTTGATCGCTAACACCGG 
               
               
                   
               
               
                 CTTTCTATCTGCAGAATGAATGCAATCACCTCCCTACTAATCACCACCACCCTCCTTGCGATTGCCCA 
               
               
                   
               
               
                 TGGGTTGACACGAATCGAAGTGCCAGTGGGGTCCAATGTCACCATGGTGGGCCCCGCCGGCAATTCC 
               
               
                   
               
               
                 ACCCTCATGTGGGAAAAATTTGTCCGCAATCAATGGGTTCATTTCTGCTCTAACCGAATCAGTATCAA 
               
               
                   
               
               
                 GCCCAGAGCCATCTGCGATGGGCAAAATCTAACTCTGATCAATGTGCAAATGATGGATGCTGGGTAC 
               
               
                   
               
               
                 TATTACGGGCAGCGGGGAGAAATCATTAATTACTGGCGACCCCACAAGGACTACATGCTGCATGTAG 
               
               
                   
               
               
                 TCGAGGCACTTCCCACTACCACCCCCACTACCACCTCTCCCACCACCACCACCACTACTACTACTACT 
               
               
                   
               
               
                 ACTACTACTACTACTACTACCACTACCGCTGCCCGCCATACCCGCAAAAGCACCATGATTAGCACAA 
               
               
                   
               
               
                 AGCCCCCTCGTGCTCACTCCCACGCCGGCGGGCCCATCGGTGCGACCTCAGAAACCACCGAGCTTTG 
               
               
                   
               
               
                 CTTCTGCCAATGCACTAACGCCAGCGCTCATGAACTGTTCGACCTGGAGAATGAGGATGTCCAGCAG 
               
               
                   
               
               
                 AGCTCCGCTTGCCTGACCCAGGAGGCTGTGGAGCCCGTTGCCCTGAAGCAGATCGGTGATTCAATAA 
               
               
                   
               
               
                 TTGACTCTTCTTCTTTTGCCACTCCCGAATACCCTCCCGATTCTACTTTCCACATCACGGGTACCAAAG 
               
               
                   
               
               
                 ACCCTAACCTCTCTTTCTACCTGATGCTGCTGCTCTGTATCTCTGTGGTCTCTTCCGCGCTGATGTTAC 
               
               
                   
               
               
                 TGGGGATGTTCTGCTGCCTGATCTGCCGCAGAAAGAGAAAAGCTCGCTCTCAGGGCCAACCACTGAT 
               
               
                   
               
               
                 GCCCTTCCCCTACCCCCCGGATTTTGCAGATAACAAGATATGAGCTCGCTGCTGACACTAACCGCTTT 
               
               
                   
               
               
                 ACTAGCCTGCGCTCTAACCCTTGTCGCTTGCGACTCGAGATTCCACAATGTCACAGCTGTGGCAGGAG 
               
               
                   
               
               
                 AAAATGTTACTTTCAACTCCACGGCCGATACCCAGTGGTCGTGGAGTGGCTCAGGTAGCTACTTAACT 
               
               
                   
               
               
                 ATCTGCAATAGCTCCACTTCCCCCGGCATATCCCCAACCAAGTACCAATGCAATGCCAGCCTGTTCAC 
               
               
                   
               
               
                 CCTCATCAACGCTTCCACCCTGGACAATGGACTCTATGTAGGCTATGTACCCTTTGGTGGGCAAGGAA 
               
               
                   
               
               
                 AGACCCACGCTTACAACCTGGAAGTTCGCCAGCCCAGAACCACTACCCAAGCTTCTCCCACCACCAC 
               
               
                   
               
               
                 CACCACCACCACCATCACCAGCAGCAGCAGCAGCAGCAGCCACAGCAGCAGCAGCAGATTATTGAC 
               
               
                   
               
               
                 TTTGGTTTTGGCCAGCTCATCTGCCGCTACCCAGGCCATCTACAGCTCTGTGCCCGAAACCACTCAGA 
               
               
                   
               
               
                 TCCACCGCCCAGAAACGACCACCGCCACCACCCTACACACCTCCAGCGATCAGATGCCGACCAACAT 
               
               
                   
               
               
                 CACCCCCTTGGCTCTTCAAATGGGACTTACAAGCCCCACTCCAAAACCAGTGGATGCGGCCGAGGTC 
               
               
                   
               
               
                 TCCGCCCTCGTCAATGACTGGGCGGGGCTGGGAATGTGGTGGTTCGCCATAGGCATGATGGCGCTCT 
               
               
                   
               
               
                 GCCTGCTTCTGCTCTGGCTCATCTGCTGCCTCCACCGCAGGCGAGCCAGACCCCCCATCTATAGACCC 
               
               
                   
               
               
                 ATCATTGTCCTGAACCCCGATAATGATGGGATCCATAGATTGGATGGCCTGAAAAACCTACTTTTTTC 
               
               
                   
               
               
                 TTTTACAGTATGATAAATTGAGACATGCCTCGCATTTTCTTGTACATGTTCCTTCTCCCACCTTTTCTG 
               
               
                   
               
               
                 GGGTGTTCTACGCTGGCCGCTGTGTCTCACCTGGAGGTAGACTGCCTCTCACCCTTCACTGTCTACCT 
               
               
                   
               
               
                 GCTTTACGGATTGGTCACCCTCACTCTCATCTGCAGCCTAATCACAGTAATCATCGCCTTCATCCAGT 
               
               
                   
               
               
                 GCATTGATTACATCTGTGTGCGCCTCGCATACTTCAGACACCACCCGCAGTACCGAGACAGGAACAT 
               
               
                   
               
               
                 TGCCCAACTTCTAAGACTGCTCTAATCATGCATAAGACTGTGATCTGCCTTCTGATCCTCTGCATCCT 
               
               
                   
               
               
                 GCCCACCCTCACCTCCTGCCAGTACACCACAAAATCTCCGCGCAAAAGACATGCCTCCTGCCGCTTCA 
               
               
                   
               
               
                 CCCAACTGTGGAATATACCCAAATGCTACAACGAAAAGAGCGAGCTCTCCGAAGCTTGGCTGTATGG 
               
               
                   
               
               
                 GGTCATCTGTGTCTTAGTTTTCTGCAGCACTGTCTTTGCCCTCATAATCTACCCCTACTTTGATTTGGG 
               
               
                   
               
               
                 ATGGAACGCGATCGATGCCATGAATTACCCCACCTTTCCCGCACCCGAGATAATTCCACTGCGACAA 
               
               
                   
               
               
                 GTTGTACCCGTTGTCGTTAATCAACGCCCCCCATCCCCTACGCCCACTGAAATCAGCTACTTTAACCT 
               
               
                   
               
               
                 AACAGGCGGAGATGACTGACGCCCTAGATCTAGAAATGGACGGCATCAGTACCGAGCAGCGTCTCCT 
               
               
                   
               
               
                 AGAGAGGCGCAGGCAGGCGGCTGAGCAAGAGCGCCTCAATCAGGAGCTCCGAGATCTCGTTAACCT 
               
               
                   
               
               
                 GCACCAGTGCAAAAGAGGCATCTTTTGTCTGGTAAAGCAGGCCAAAGTCACCTACGAGAAGACCGG 
               
               
                   
               
               
                 CAACAGCCACCGCCTCAGTTACAAATTGCCCACCCAGCGCCAGAAGCTGGTGCTCATGGTGGGTGAG 
               
               
                   
               
               
                 AATCCCATCACCGTCACCCAGCACTCGGTAGAGACCGAGGGGTGTCTGCACTCCCCCTGTCGGGGTC 
               
               
                   
               
               
                 CAGAAGACCTCTGCACCCTGGTAAAGACCCTGTGCGGTCTCAGAGATTTAGTCCCCTTTAACTAATCA 
               
               
                   
               
               
                 AACACTGGAATCAATAAAAAGAATCACTTACTTAAAATCAGACAGCAGGTCTCTGTCCAGTTTATTC 
               
               
                   
               
               
                 AGCAGCACCTCCTTCCCCTCCTCCCAACTCTGGTACTCCAAACGCCTTCTGGCGGCAAACTTCCTCCA 
               
               
                   
               
               
                 CACCCTGAAGGGAATGTCAGATTCTTGCTCCTGTCCCTCCGCACCCACTATCTTCATGTTGTTGCAGA 
               
               
                   
               
               
                 TGAAGCGCACCAAAACGTCTGACGAGAGCTTCAACCCCGTGTACCCCTATGACACGGAAAGCGGCCC 
               
               
                   
               
               
                 TCCCTCCGTCCCTTTCCTCACCCCTCCCTTCGTGTCTCCCGATGGATTCCAAGAAAGTCCCCCCGGGGT 
               
               
                   
               
               
                 CCTGTCTCTGAACCTGGCCGAGCCCCTGGTCACTTCCCACGGCATGCTCGCCCTGAAAATGGGAAGT 
               
               
                   
               
               
                 GGCCTCTCCCTGGACGACGCTGGCAACCTCACCTCTCAAGATATCACCACCGCTAGCCCTCCCCTCAA 
               
               
                   
               
               
                 AAAAACCAAGACCAACCTCAGCCTAGAAACCTCATCCCCCCTAACTGTGAGCACCTCAGGCGCCCTC 
               
               
                   
               
               
                 ACCGTAGCAGCCGCCGCTCCCCTGGCGGTGGCCGGCACCTCCCTCACCATGCAATCAGAGGCCCCCC 
               
               
                   
               
               
                 TGACAGTACAGGATGCAAAACTCACCCTGGCCACCAAAGGCCCCCTGACCGTGTCTGAAGGCAAACT 
               
               
                   
               
               
                 GGCCTTGCAAACATCGGCCCCGCTGACGGCCGCTGACAGCAGCACCCTCACAGTCAGTGCCACACCA 
               
               
                   
               
               
                 CCCCTTAGCACAAGCAATGGCAGCTTGGGTATTGACATGCAAGCCCCCATTTACACCACCAATGGAA 
               
               
                   
               
               
                 AACTAGGACTTAACTTTGGCGCTCCCCTGCATGTGGTAGACAGCCTAAATGCACTGACTGTAGTTACT 
               
               
                   
               
               
                 GGCCAAGGTCTTACGATAAACGGAACAGCCCTACAAACTAGAGTCTCAGGTGCCCTCAACTATGACA 
               
               
                   
               
               
                 CATCAGGAAACCTAGAATTGAGAGCTGCAGGGGGTATGCGAGTTGATGCAAATGGTCAACTTATCCT 
               
               
                   
               
               
                 TGATGTAGCTTACCCATTTGATGCACAAAACAATCTCAGCCTTAGGCTTGGACAGGGACCCCTGTTTG 
               
               
                   
               
               
                 TTAACTCTGCCCACAACTTGGATGTTAACTACAACAGAGGCCTCTACCTGTTCACATCTGGAAATACC 
               
               
                   
               
               
                 AAAAAGCTAGAAGTTAATATCAAAACAGCCAAGGGTCTCATTTATGATGACACTGCTATAGCAATCA 
               
               
                   
               
               
                 ATGCGGGTGATGGGCTACAGTTTGACTCAGGCTCAGATACAAATCCATTAAAAACTAAACTTGGATT 
               
               
                   
               
               
                 AGGACTGGATTATGACTCCAGCAGAGCCATAATTGCTAAACTGGGAACTGGCCTAAGCTTTGACAAC 
               
               
                   
               
               
                 ACAGGTGCCATCACAGTAGGCAACAAAAATGATGACAAGCTTACCTTGTGGACCACACCAGACCCAT 
               
               
                   
               
               
                 CCCCTAACTGTAGAATCTATTCAGAGAAAGATGCTAAATTCACACTTGTTTTGACTAAATGCGGCAGT 
               
               
                   
               
               
                 CAGGTGTTGGCCAGCGTTTCTGTTTTATCTGTAAAAGGTAGCCTTGCGCCCATCAGTGGCACAGTAAC 
               
               
                   
               
               
                 TAGTGCTCAGATTGTCCTCAGATTTGATGAAAATGGAGTTCTACTAAGCAATTCTTCCCTTGACCCTC 
               
               
                   
               
               
                 AATACTGGAACTACAGAAAAGGTGACCTTACAGAGGGCACTGCATATACCAACGCAGTGGGATTTAT 
               
               
                   
               
               
                 GCCCAACCTCACAGCATACCCAAAAACACAGAGCCAAACTGCTAAAAGCAACATTGTAAGTCAGGTT 
               
               
                   
               
               
                 TACTTGAATGGGGACAAATCCAAACCCATGACCCTCACCATTACCCTCAATGGAACTAATGAAACAG 
               
               
                   
               
               
                 GAGATGCCACAGTAAGCACTTACTCCATGTCATTCTCATGGAACTGGAATGGAAGTAATTACATTAA 
               
               
                   
               
               
                 TGAAACGTTCCAAACCAACTCCTTCACCTTCTCCTACATCGCCCAAGAATAAAAAGCATGACGCTGTT 
               
               
                   
               
               
                 GATTTGATTCAATGTGTTTCTGTTTTATTTTCAAGCACAACAAAATCATTCAAGTCATTCTTCCATCTT 
               
               
                   
               
               
                 AGCTTAATAGACACAGTAGCTTAATAGACCCAGTAGTGCAAAGCCCCATTCTAGCTTATAGATCAGA 
               
               
                   
               
               
                 CAGTGATAATTAACCACCACCACCACCATACCTTTTGATTCAGGAAATCATGATCATCACAGGATCCT 
               
               
                   
               
               
                 AGTCTTCAGGCCGCCCCCTCCCTCCCAAGACACAGAATACACAGTCCTCTCCCCCCGACTGGCTTTAA 
               
               
                   
               
               
                 ATAACACCATCTGGTTGGTCACAGACATGTTCTTAGGGGTTATATTCCACACGGTCTCCTGCCGCGCC 
               
               
                   
               
               
                 AGGCGCTCGTCGGTGATGTTGATAAACTCTCCCGGCAGCTCGCTCAAGTTCACGTCGCTGTCCAGCGG 
               
               
                   
               
               
                 CTGAACCTCCGGCTGACGCGATAACTGTGCGACCGGCTGCTGGACGAACGGAGGCCGCGCCTACAAG 
               
               
                   
               
               
                 GGGGTAGAGTCATAATCCTCGGTCAGGATAGGGCGGTGATGCAGCAGCAGCGAGCGAAACATCTGC 
               
               
                   
               
               
                 TGCCGCCGCCGCTCCGTCCGGCAGGAAAACAACACGCCGGTGGTCTCCTCCGCGATAATCCGCACCG 
               
               
                   
               
               
                 CCCGCAGCATCAGCTTCCTCGTTCTCCGCGCGCAGCACCTCACCCTTATCTCGCTCAAATCGGCGCAG 
               
               
                   
               
               
                 TAGGTACAGCACAGCACCACGATGTTATTCATGATCCCACAGTGCAGGGCGCTGTATCCAAAGCTCA 
               
               
                   
               
               
                 TGCCGGGAACCACCGCCCCCACGTGGCCATCGTACCACAAGCGCACGTAAATCAAGTGTCGACCCCT 
               
               
                   
               
               
                 CATGAACGCGCTGGACACAAACATTACTTCCTTGGGCATGTTGTAATTCACCACCTCCCGGTACCAGA 
               
               
                   
               
               
                 TAAACCTCTGGTTGAACAGGGCACCTTCCACCACCATCCTGAACCAAGAGGCCAGAACCTGCCCACC 
               
               
                   
               
               
                 GGCTATGCACTGCAGGGAACCCGGGTTGGAACAATGACAATGCAGACTCCAAGGCTCGTAACCGTG 
               
               
                   
               
               
                 GATCATCCGGCTGCTGAAGGCATCGATGTTGGCACAACACAGACACACGTGCATGCACTTTCTCATG 
               
               
                   
               
               
                 ATTAGCAGCTCTTCCCTCGTCAGGATCATATCCCAAGGAATAACCCATTCTTGAATCAACGTAAAACC 
               
               
                   
               
               
                 CACACAGCAGGGAAGGCCTCGCACATAACTCACGTTGTGCATGGTCAGCGTGTTGCATTCCGGAAAC 
               
               
                   
               
               
                 AGCGGATGATCCTCCAGTATCGAGGCGCGGGTCTCCTTCTCACAGGGAGGTAAAGGGTCCCTGCTGT 
               
               
                   
               
               
                 ACGGACTGCGCCGGGACGACCGAGATCGTGTTGAGCGTAGTGTCATGGAAAAGGGAACGCCGGACG 
               
               
                   
               
               
                 TGGTCATACTTCTTGAAGCAGAACCAGGTTCGCGCGTGGCAGGCCTCCTTGCGTCTGCGGTCTCGCCG 
               
               
                   
               
               
                 TCTAGCTCGCTCCGTGTGATAGTTGTAGTACAGCCACTCCCGCAGAGCGTCGAGGCGCACCCTGGCTT 
               
               
                   
               
               
                 CCGGATCTATGTAGACTCCGTCTTGCACCGCGGCCCTGATAATATCCACCACCGTAGAATAAGCAAC 
               
               
                   
               
               
                 ACCCAGCCAAGCAATACACTCGCTCTGCGAGCGGCAGACAGGAGGAGCGGGCAGAGATGGGAGAAC 
               
               
                   
               
               
                 CATGATAAAAAACTTTTTTTAAAGAATATTTTCCAATTCTTCGAAAGTAAGATCTATCAAGTGGCAGC 
               
               
                   
               
               
                 GCTCCCCTCCACTGGCGCGGTCAAACTCTACGGCCAAAGCACAGACAACGGCATTTCTAAGATGTTC 
               
               
                   
               
               
                 CTTAATGGCGTCCAAAAGACACACCGCTCTCAAGTTGCAGTAAACTATGAATGAAAACCCATCCGGC 
               
               
                   
               
               
                 TGATTTTCCAATATAGACGCGCCGGCAGCGTCCACCAAACCCAGATAATTTTCTTCTCTCCAGCGGTT 
               
               
                   
               
               
                 TACGATCTGTCTAAGCAAATCCCTTATATCAAGTCCGACCATGCCAAAAATCTGCTCAAGAGCGCCCT 
               
               
                   
               
               
                 CCACCTTCATGTACAAGCAGCGCATCATGATTGCAAAAATTCAGGTTCTTCAGAGACCTGTATAAGA 
               
               
                   
               
               
                 TTCAAAATGGGAACATTAACAAAAATTCCTCTGTCGCGCAGATCCCTTCGCAGGGCAAGCTGAACAT 
               
               
                   
               
               
                 AATCAGACAGGTCCGAACGGACCAGTGAGGCCAAATCCCCACCAGGAACCAGATCCAGAGACCCTA 
               
               
                   
               
               
                 TACTGATTATGACGCGCATACTCGGGGCTATGCTGACCAGCGTAGCGCCGATGTAGGCGTGCTGCAT 
               
               
                   
               
               
                 GGGCGGCGAGATAAAATGCAAAGTGCTGGTTAAAAAATCAGGCAAAGCCTCGCGCAAAAAAGCTAA 
               
               
                   
               
               
                 CACATCATAATCATGCTCATGCAGGTAGTTGCAGGTAAGCTCAGGAACCAAAACGGAATAACACACG 
               
               
                   
               
               
                 ATTTTCCTCTCAAACATGACTTCGCGGATACTGCGTAAAACAAAAAATTATAAATAAAAAATTAATT 
               
               
                   
               
               
                 AAATAACTTAAACATTGGAAGCCTGTCTCACAACAGGAAAAACCACTTTAATCAACATAAGACGGGC 
               
               
                   
               
               
                 CACGGGCATGCCGGCATAGCCGTAAAAAAATTGGTCCCCGTGATTAACAAGTACCACAGACAGCTCC 
               
               
                   
               
               
                 CCGGTCATGTCGGGGGTCATCATGTGAGACTCTGTATACACGTCTGGATTGTGAACATCAGACAAAC 
               
               
                   
               
               
                 AAAGAAATCGAGCCACGTAGCCCGGAGGTATAATCACCCGCAGGCGGAGGTACAGCAAAACGACCC 
               
               
                   
               
               
                 CCATAGGAGGAATCACAAAATTAGTAGGAGAAAAAAATACATAAACACCAGAAAAACCCTGTTGCT 
               
               
                   
               
               
                 GAGGCAAAATAGCGCCCTCCCGATCCAAAACAACATAAAGCGCTTCCACAGGAGCAGCCATAACAA 
               
               
                   
               
               
                 AGACCCGAGTCTTACCAGTAAAAGAAAAAAGATCTCTCAACGCAGCACCAGCACCAACACTTCGCA 
               
               
                   
               
               
                 GTGTAAAAGGCCAAGTGCCGAGAGAGTATATATAGGAATAAAAAGTGACGTAAACGGGCAAAGTCC 
               
               
                   
               
               
                 AAAAAACGCCCAGAAAAACCGCACGCGAACCTACGCCCCGAAACGAAAGCCAAAAAACACTAGAC 
               
               
                   
               
               
                 ACTCCCTTCCGGCGTCAACTTCCGCTTTCCCACGCTACGTCACTTGCCCCAGTCAAACAAACTACATA 
               
               
                   
               
               
                 TCCCGAACTTCCAAGTCGCCACGCCCAAAACACCGCCTACACCTCCCCGCCCGCCGGCCCGCCCCCA 
               
               
                   
               
               
                 AACCCGCCTCCCGCCCCGCGCCCCGCCCCGCGCCGCCCATCTCATTATCATATTGGCTTCAATCCAAA 
               
               
                   
               
               
                 ATAAGGTATATTATTGATGATGGTTTAAACGGATCCTCTAGAGTCGACCTGCAGGCATGCAAGCTTG 
               
               
                   
               
               
                 AGTATTCTATAGTGTCACCTAAATAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTG 
               
               
                   
               
               
                 TTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAA 
               
               
                   
               
               
                 TGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTG 
               
               
                   
               
               
                 CCAGCTGCATTAATGAATCGGCCAACGCGAACCCCTTGCGGCCGCCCGGGCCGTCGACCAATTCTCA 
               
               
                   
               
               
                 TGTTTGACAGCTTATCATCGAATTTCTGCCATTCATCCGCTTATTATCACTTATTCAGGCGTAGCAACC 
               
               
                   
               
               
                 AGGCGTTTAAGGGCACCAATAACTGCCTTAAAAAAATTACGCCCCGCCCTGCCACTCATCGCAGTAC 
               
               
                   
               
               
                 TGTTGTAATTCATTAAGCATTCTGCCGACATGGAAGCCATCACAAACGGCATGATGAACCTGAATCG 
               
               
                   
               
               
                 CCAGCGGCATCAGCACCTTGTCGCCTTGCGTATAATATTTGCCCATGGTGAAAACGGGGGCGAAGAA 
               
               
                   
               
               
                 GTTGTCCATATTGGCCACGTTTAAATCAAAACTGGTGAAACTCACCCAGGGATTGGCTGAGACGAAA 
               
               
                   
               
               
                 AACATATTCTCAATAAACCCTTTAGGGAAATAGGCCAGGTTTTCACCGTAACACGCCACATCTTGCG 
               
               
                   
               
               
                 AATATATGTGTAGAAACTGCCGGAAATCGTCGTGGTATTCACTCCAGAGCGATGAAAACGTTTCAGT 
               
               
                   
               
               
                 TTGCTCATGGAAAACGGTGTAACAAGGGTGAACACTATCCCATATCACCAGCTCACCGTCTTTCATTG 
               
               
                   
               
               
                 CCATACGGAATTCCGGATGAGCATTCATCAGGCGGGCAAGAATGTGAATAAAGGCCGGATAAAACT 
               
               
                   
               
               
                 TGTGCTTATTTTTCTTTACGGTCTTTAAAAAGGCCGTAATATCCAGCTGAACGGTCTGGTTATAGGTA 
               
               
                   
               
               
                 CATTGAGCAACTGACTGAAATGCCTCAAAATGTTCTTTACGATGCCATTGGGATATATCAACGGTGGT 
               
               
                   
               
               
                 ATATCCAGTGATTTTTTTCTCCATTTTAGCTTCCTTAGCTCCTGAAAATCTCGATAACTCAAAAAATAC 
               
               
                   
               
               
                 GCCCGGTAGTGATCTTATTTCATTATGGTGAAAGTTGGAACCTCTTACGTGCCGATCAACGTCTCATT 
               
               
                   
               
               
                 TTCGCCAAAAGTTGGCCCAGGGCTTCCCGGTATCAACAGGGACACCAGGATTTATTTATTCTGCGAA 
               
               
                   
               
               
                 GTGATCTTCCGTCACAGGTATTTATTCGCGATAAGCTCATGGAGCGGCGTAACCGTCGCACAGGAAG 
               
               
                   
               
               
                 GACAGAGAAAGCGCGGATCTGGGAAGTGACGGACAGAACGGTCAGGACCTGGATTGGGGAGGCGGT 
               
               
                   
               
               
                 TGCCGCCGCTGCTGCTGACGGTGTGACGTTCTCTGTTCCGGTCACACCACATACGTTCCGCCATTCCT 
               
               
                   
               
               
                 ATGCGATGCACATGCTGTATGCCGGTATACCGCTGAAAGTTCTGCAAAGCCTGATGGGACATAAGTC 
               
               
                   
               
               
                 CATCAGTTCAACGGAAGTCTACACGAAGGTTTTTGCGCTGGATGTGGCTGCCCGGCACCGGGTGCAG 
               
               
                   
               
               
                 TTTGCGATGCCGGAGTCTGATGCGGTTGCGATGCTGAAACAATTATCCTGAGAATAAATGCCTTGGC 
               
               
                   
               
               
                 CTTTATATGGAAATGTGGAACTGAGTGGATATGCTGTTTTTGTCTGTTAAACAGAGAAGCTGGCTGTT 
               
               
                   
               
               
                 ATCCACTGAGAAGCGAACGAAACAGTCGGGAAAATCTCCCATTATCGTAGAGATCCGCATTATTAAT 
               
               
                   
               
               
                 CTCAGGAGCCTGTGTAGCGTTTATAGGAAGTAGTGTTCTGTCATGATGCCTGCAAGCGGTAACGAAA 
               
               
                   
               
               
                 ACGATTTGAATATGCCTTCAGGAACAATAGAAATCTTCGTGCGGTGTTACGTTGAAGTGGAGCGGAT 
               
               
                   
               
               
                 TATGTCAGCAATGGACAGAACAACCTAATGAACACAGAACCATGATGTGGTCTGTCCTTTTACAGCC 
               
               
                   
               
               
                 AGTAGTGCTCGCCGCAGTCGAGCGACAGGGCGAAGCCCTCGAGTGAGCGAGGAAGCACCAGGGAAC 
               
               
                   
               
               
                 AGCACTTATATATTCTGCTTACACACGATGCCTGAAAAAACTTCCCTTGGGGTTATCCACTTATCCAC 
               
               
                   
               
               
                 GGGGATATTTTTATAATTATTTTTTTTATAGTTTTTAGATCTTCTTTTTTAGAGCGCCTTGTAGGCCTTT 
               
               
                   
               
               
                 ATCCATGCTGGTTCTAGAGAAGGTGTTGTGACAAATTGCCCTTTCAGTGTGACAAATCACCCTCAAAT 
               
               
                   
               
               
                 GACAGTCCTGTCTGTGACAAATTGCCCTTAACCCTGTGACAAATTGCCCTCAGAAGAAGCTGTTTTTT 
               
               
                   
               
               
                 CACAAAGTTATCCCTGCTTATTGACTCTTTTTTATTTAGTGTGACAATCTAAAAACTTGTCACACTTCA 
               
               
                   
               
               
                 CATGGATCTGTCATGGCGGAAACAGCGGTTATCAATCACAAGAAACGTAAAAATAGCCCGCGAATC 
               
               
                   
               
               
                 GTCCAGTCAAACGACCTCACTGAGGCGGCATATAGTCTCTCCCGGGATCAAAAACGTATGCTGTATC 
               
               
                   
               
               
                 TGTTCGTTGACCAGATCAGAAAATCTGATGGCACCCTACAGGAACATGACGGTATCTGCGAGATCCA 
               
               
                   
               
               
                 TGTTGCTAAATATGCTGAAATATTCGGATTGACCTCTGCGGAAGCCAGTAAGGATATACGGCAGGCA 
               
               
                   
               
               
                 TTGAAGAGTTTCGCGGGGAAGGAAGTGGTTTTTTATCGCCCTGAAGAGGATGCCGGCGATGAAAAAG 
               
               
                   
               
               
                 GCTATGAATCTTTTCCTTGGTTTATCAAACGTGCGCACAGTCCATCCAGAGGGCTTTACAGTGTACAT 
               
               
                   
               
               
                 ATCAACCCATATCTCATTCCCTTCTTTATCGGGTTACAGAACCGGTTTACGCAGTTTCGGCTTAGTGA 
               
               
                   
               
               
                 AACAAAAGAAATCACCAATCCGTATGCCATGCGTTTATACGAATCCCTGTGTCAGTATCGTAAGCCG 
               
               
                   
               
               
                 GATGGCTCAGGCATCGTCTCTCTGAAAATCGACTGGATCATAGAGCGTTACCAGCTGCCTCAAAGTT 
               
               
                   
               
               
                 ACCAGCGTATGCCTGACTTCCGCCGCCGCTTCCTGCAGGTCTGTGTTAATGAGATCAACAGCAGAACT 
               
               
                   
               
               
                 CCAATGCGCCTCTCATACATTGAGAAAAAGAAAGGCCGCCAGACGACTCATATCGTATTTTCCTTCC 
               
               
                   
               
               
                 GCGATATCACTTCCATGACGACAGGATAGTCTGAGGGTTATCTGTCACAGATTTGAGGGTGGTTCGTC 
               
               
                   
               
               
                 ACATTTGTTCTGACCTACTGAGGGTAATTTGTCACAGTTTTGCTGTTTCCTTCAGCCTGCATGGATTTT 
               
               
                   
               
               
                 CTCATACTTTTTGAACTGTAATTTTTAAGGAAGCCAAATTTGAGGGCAGTTTGTCACAGTTGATTTCC 
               
               
                   
               
               
                 TTCTCTTTCCCTTCGTCATGTGACCTGATATCGGGGGTTAGTTCGTCATCATTGATGAGGGTTGATTAT 
               
               
                   
               
               
                 CACAGTTTATTACTCTGAATTGGCTATCCGCGTGTGTACCTCTACCTGGAGTTTTTCCCACGGTGGAT 
               
               
                   
               
               
                 ATTTCTTCTTGCGCTGAGCGTAAGAGCTATCTGACAGAACAGTTCTTCTTTGCTTCCTCGCCAGTTCGC 
               
               
                   
               
               
                 TCGCTATGCTCGGTTACACGGCTGCGGCGAGCGCTAGTGATAATAAGTGACTGAGGTATGTGCTCTTC 
               
               
                   
               
               
                 TTATCTCCTTTTGTAGTGTTGCTCTTATTTTAAACAACTTTGCGGTTTTTTGATGACTTTGCGATTTTGT 
               
               
                   
               
               
                 TGTTGCTTTGCAGTAAATTGCAAGATTTAATAAAAAAACGCAAAGCAATGATTAAAGGATGTTCAGA 
               
               
                   
               
               
                 ATGAAACTCATGGAAACACTTAACCAGTGCATAAACGCTGGTCATGAAATGACGAAGGCTATCGCCA 
               
               
                   
               
               
                 TTGCACAGTTTAATGATGACAGCCCGGAAGCGAGGAAAATAACCCGGCGCTGGAGAATAGGTGAAG 
               
               
                   
               
               
                 CAGCGGATTTAGTTGGGGTTTCTTCTCAGGCTATCAGAGATGCCGAGAAAGCAGGGCGACTACCGCA 
               
               
                   
               
               
                 CCCGGATATGGAAATTCGAGGACGGGTTGAGCAACGTGTTGGTTATACAATTGAACAAATTAATCAT 
               
               
                   
               
               
                 ATGCGTGATGTGTTTGGTACGCGATTGCGACGTGCTGAAGACGTATTTCCACCGGTGATCGGGGTTGC 
               
               
                   
               
               
                 TGCCCATAAAGGTGGCGTTTACAAAACCTCAGTTTCTGTTCATCTTGCTCAGGATCTGGCTCTGAAGG 
               
               
                   
               
               
                 GGCTACGTGTTTTGCTCGTGGAAGGTAACGACCCCCAGGGAACAGCCTCAATGTATCACGGATGGGT 
               
               
                   
               
               
                 ACCAGATCTTCATATTCATGCAGAAGACACTCTCCTGCCTTTCTATCTTGGGGAAAAGGACGATGTCA 
               
               
                   
               
               
                 CTTATGCAATAAAGCCCACTTGCTGGCCGGGGCTTGACATTATTCCTTCCTGTCTGGCTCTGCACCGT 
               
               
                   
               
               
                 ATTGAAACTGAGTTAATGGGCAAATTTGATGAAGGTAAACTGCCCACCGATCCACACCTGATGCTCC 
               
               
                   
               
               
                 GACTGGCCATTGAAACTGTTGCTCATGACTATGATGTCATAGTTATTGACAGCGCGCCTAACCTGGGT 
               
               
                   
               
               
                 ATCGGCACGATTAATGTCGTATGTGCTGCTGATGTGCTGATTGTTCCCACGCCTGCTGAGTTGTTTGA 
               
               
                   
               
               
                 CTACACCTCCGCACTGCAGTTTTTCGATATGCTTCGTGATCTGCTCAAGAACGTTGATCTTAAAGGGT 
               
               
                   
               
               
                 TCGAGCCTGATGTACGTATTTTGCTTACCAAATACAGCAATAGTAATGGCTCTCAGTCCCCGTGGATG 
               
               
                   
               
               
                 GAGGAGCAAATTCGGGATGCCTGGGGAAGCATGGTTCTAAAAAATGTTGTACGTGAAACGGATGAA 
               
               
                   
               
               
                 GTTGGTAAAGGTCAGATCCGGATGAGAACTGTTTTTGAACAGGCCATTGATCAACGCTCTTCAACTG 
               
               
                   
               
               
                 GTGCCTGGAGAAATGCTCTTTCTATTTGGGAACCTGTCTGCAATGAAATTTTCGATCGTCTGATTAAA 
               
               
                   
               
               
                 CCACGCTGGGAGATTAGATAATGAAGCGTGCGCCTGTTATTCCAAAACATACGCTCAATACTCAACC 
               
               
                   
               
               
                 GGTTGAAGATACTTCGTTATCGACACCAGCTGCCCCGATGGTGGATTCGTTAATTGCGCGCGTAGGA 
               
               
                   
               
               
                 GTAATGGCTCGCGGTAATGCCATTACTTTGCCTGTATGTGGTCGGGATGTGAAGTTTACTCTTGAAGT 
               
               
                   
               
               
                 GCTCCGGGGTGATAGTGTTGAGAAGACCTCTCGGGTATGGTCAGGTAATGAACGTGACCAGGAGCTG 
               
               
                   
               
               
                 CTTACTGAGGACGCACTGGATGATCTCATCCCTTCTTTTCTACTGACTGGTCAACAGACACCGGCGTT 
               
               
                   
               
               
                 CGGTCGAAGAGTATCTGGTGTCATAGAAATTGCCGATGGGAGTCGCCGTCGTAAAGCTGCTGCACTT 
               
               
                   
               
               
                 ACCGAAAGTGATTATCGTGTTCTGGTTGGCGAGCTGGATGATGAGCAGATGGCTGCATTATCCAGAT 
               
               
                   
               
               
                 TGGGTAACGATTATCGCCCAACAAGTGCTTATGAACGTGGTCAGCGTTATGCAAGCCGATTGCAGAA 
               
               
                   
               
               
                 TGAATTTGCTGGAAATATTTCTGCGCTGGCTGATGCGGAAAATATTTCACGTAAGATTATTACCCGCT 
               
               
                   
               
               
                 GTATCAACACCGCCAAATTGCCTAAATCAGTTGTTGCTCTTTTTTCTCACCCCGGTGAACTATCTGCCC 
               
               
                   
               
               
                 GGTCAGGTGATGCACTTCAAAAAGCCTTTACAGATAAAGAGGAATTACTTAAGCAGCAGGCATCTAA 
               
               
                   
               
               
                 CCTTCATGAGCAGAAAAAAGCTGGGGTGATATTTGAAGCTGAAGAAGTTATCACTCTTTTAACTTCTG 
               
               
                   
               
               
                 TGCTTAAAACGTCATCTGCATCAAGAACTAGTTTAAGCTCACGACATCAGTTTGCTCCTGGAGCGACA 
               
               
                   
               
               
                 GTATTGTATAAGGGCGATAAAATGGTGCTTAACCTGGACAGGTCTCGTGTTCCAACTGAGTGTATAG 
               
               
                   
               
               
                 AGAAAATTGAGGCCATTCTTAAGGAACTTGAAAAGCCAGCACCCTGATGCGACCACGTTTTAGTCTA 
               
               
                   
               
               
                 CGTTTATCTGTCTTTACTTAATGTCCTTTGTTACAGGCCAGAAAGCATAACTGGCCTGAATATTCTCTC 
               
               
                   
               
               
                 TGGGCCCACTGTTCCACTTGTATCGTCGGTCTGATAATCAGACTGGGACCACGGTCCCACTCGTATCG 
               
               
                   
               
               
                 TCGGTCTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACC 
               
               
                   
               
               
                 ACGGTCCCACTCGTATCGTCGGTCTGATAATCAGACTGGGACCACGGTCCCACTCGTATCGTCGGTCT 
               
               
                   
               
               
                 GATTATTAGTCTGGGACCATGGTCCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGGTCC 
               
               
                   
               
               
                 CACTCGTATCGTCGGTCTGATTATTAGTCTGGAACCACGGTCCCACTCGTATCGTCGGTCTGATTATT 
               
               
                   
               
               
                 AGTCTGGGACCACGGTCCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGATCCCACTCGT 
               
               
                   
               
               
                 GTTGTCGGTCTGATTATCGGTCTGGGACCACGGTCCCACTTGTATTGTCGATCAGACTATCAGCGTGA 
               
               
                   
               
               
                 GACTACGATTCCATCAATGCCTGTCAAGGGCAAGTATTGACATGTCGTCGTAACCTGTAGAACGGAG 
               
               
                   
               
               
                 TAACCTCGGTGTGCGGTTGTATGCCTGCTGTGGATTGCTGCTGTGTCCTGCTTATCCACAACATTTTGC 
               
               
                   
               
               
                 GCACGGTTATGTGGACAAAATACCTGGTTACCCAGGCCGTGCCGGCACGTTAACCGGGCTGCATCCG 
               
               
                   
               
               
                 ATGCAAGTGTGTCGCTGTCGACGAGCTCGCGAGCTCGGACATGAGGTTGCCCCGTATTCAGTGTCGC 
               
               
                   
               
               
                 TGATTTGTATTGTCTGAAGTTGTTTTTACGTTAAGTTGATGCAGATCAATTAATACGATACCTGCGTC 
               
               
                   
               
               
                 ATAATTGATTATTTGACGTGGTTTGATGGCCTCCACGCACGTTGTGATATGTAGATGATAATCATTAT 
               
               
                   
               
               
                 CACTTTACGGGTCCTTTCCGGTGATCCGACAGGTTACGGGGCGGCGACCTCGCGGGTTTTCGCTATTT 
               
               
                   
               
               
                 ATGAAAATTTTCCGGTTTAAGGCGTTTCCGTTCTTCTTCGTCATAACTTAATGTTTTTATTTAAAATAC 
               
               
                   
               
               
                 CCTCTGAAAAGAAAGGAAACGACAGGTGCTGAAAGCGAGCTTTTTGGCCTCTGTCGTTTCCTTTCTCT 
               
               
                   
               
               
                 GTTTTTGTCCGTGGAATGAACAATGGAAGTCCGAGCTCATCGCTAATAACTTCGTATAGCATACATTA 
               
               
                   
               
               
                 TACGAAGTTATATTCGATGCGGCCGCAAGGGGTTCGCGTCAGCGGGTGTTGGCGGGTGTCGGGGCTG 
               
               
                   
               
               
                 GCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCGGTGTGAAATACCGCAC 
               
               
                   
               
               
                 AGATGCGTAAGGAGAAAATACCGCATCAGGCGCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAG 
               
               
                   
               
               
                 GGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATT 
               
               
                   
               
               
                 AAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAGTGAATTGTAATAC 
               
               
                   
               
               
                 GACTCACTATAGGGCGAATTCGAGCTCGGTACCCGGGGATCCTCGTTTAAAC 
               
               
                   
               
               
                 Polynucleotide sequence encoding wild type ChAd155 
               
               
                 SEQ ID NO: 10 
                   
               
               
                 CATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGATGGGCGGCGCGGGGCG 
                   
               
               
                   
               
               
                 GGAGGCGGGTCCGGGGGCGGGCCGGCGGGCGGGGCGGTGTGGCGGAAGTGGACTTTGTAAGTGTGG 
               
               
                   
               
               
                 CGGATGTGACTTGCTAGTGCCGGGCGCGGTAAAAGTGACGTTTTCCGTGCGCGACAACGCCCACGGG 
               
               
                   
               
               
                 AAGTGACATTTTTCCCGCGGTTTTTACCGGATGTTGTAGTGAATTTGGGCGTAACCAAGTAAGATTTG 
               
               
                   
               
               
                 GCCATTTTCGCGGGAAAACTGAAACGGGGAAGTGAAATCTGATTAATTTCGCGTTAGTCATACCGCG 
               
               
                   
               
               
                 TAATATTTGTCGAGGGCCGAGGGACTTTGGCCGATTACGTGGAGGACTCGCCCAGGTGTTTTTTGAG 
               
               
                   
               
               
                 GTGAATTTCCGCGTTCCGGGTCAAAGTCTCCGTTTTATTATTATAGTCAGCTGACGCGGAGTGTATTT 
               
               
                   
               
               
                 ATACCCTCTGATCTCGTCAAGTGGCCACTCTTGAGTGCCAGCGAGTAGAGTTTTCTCCTCTGCCGCTC 
               
               
                   
               
               
                 TCCGCTCCGCTCCGCTCGGCTCTGACACCGGGGAAAAAATGAGACATTTCACCTACGATGGCGGTGT 
               
               
                   
               
               
                 GCTCACCGGCCAGCTGGCTGCTGAAGTCCTGGACACCCTGATCGAGGAGGTATTGGCCGATAATTAT 
               
               
                   
               
               
                 CCTCCCTCGACTCCTTTTGAGCCACCTACACTTCACGAACTCTACGATCTGGATGTGGTGGGGCCCAG 
               
               
                   
               
               
                 CGATCCGAACGAGCAGGCGGTTTCCAGTTTTTTTCCAGAGTCCATGTTGTTGGCCAGCCAGGAGGGG 
               
               
                   
               
               
                 GTCGAACTTGAGACCCCTCCTCCGATCGTGGATTCCCCCGATCCGCCGCAGCTGACTAGGCAGCCCG 
               
               
                   
               
               
                 AGCGCTGTGCGGGACCTGAGACTATGCCCCAGCTGCTACCTGAGGTGATCGATCTCACCTGTAATGA 
               
               
                   
               
               
                 GTCTGGTTTTCCACCCAGCGAGGATGAGGACGAAGAGGGTGAGCAGTTTGTGTTAGATTCTGTGGAA 
               
               
                   
               
               
                 CAACCCGGGCGAGGATGCAGGTCTTGTCAATATCACCGGAAAAACACAGGAGACTCCCAGATTATGT 
               
               
                   
               
               
                 GTTCTCTGTGTTATATGAAGATGACCTGTATGTTTATTTACAGTAAGTTTATCATCTGTGGGCAGGTG 
               
               
                   
               
               
                 GGCTATAGTGTGGGTGGTGGTCTTTGGGGGGTTTTTTAATATATGTCAGGGGTTATGCTGAAGACTTT 
               
               
                   
               
               
                 TTTATTGTGATTTTTAAAGGTCCAGTGTCTGAGCCCGAGCAAGAACCTGAACCGGAGCCTGAGCCTTC 
               
               
                   
               
               
                 TCGCCCCAGGAGAAAGCCTGTAATCTTAACTAGACCCAGCGCACCGGTAGCGAGAGGCCTCAGCAGC 
               
               
                   
               
               
                 GCGGAGACCACCGACTCCGGTGCTTCCTCATCACCCCCGGAGATTCACCCCCTGGTGCCCCTGTGTCC 
               
               
                   
               
               
                 CGTTAAGCCCGTTGCCGTGAGAGTCAGTGGGCGGCGGTCTGCTGTGGAGTGCATTGAGGACTTGCTT 
               
               
                   
               
               
                 TTTGATTCACAGGAACCTTTGGACTTGAGCTTGAAACGCCCCAGGCATTAAACCTGGTCACCTGGACT 
               
               
                   
               
               
                 GAATGAGTTGACGCCTATGTTTGCTTTTGAATGACTTAATGTGTATAGATAATAAAGAGTGAGATAAT 
               
               
                   
               
               
                 GTTTTAATTGCATGGTGTGTTTAACTTGGGCGGAGTCTGCTGGGTATATAAGCTTCCCTGGGCTAAAC 
               
               
                   
               
               
                 TTGGTTACACTTGACCTCATGGAGGCCTGGGAGTGTTTGGAGAACTTTGCCGGAGTTCGTGCCTTGCT 
               
               
                   
               
               
                 GGACGAGAGCTCTAACAATACCTCTTGGTGGTGGAGGTATTTGTGGGGCTCTCCCCAGGGCAAGTTA 
               
               
                   
               
               
                 GTTTGTAGAATCAAGGAGGATTACAAGTGGGAATTTGAAGAGCTTTTGAAATCCTGTGGTGAGCTAT 
               
               
                   
               
               
                 TGGATTCTTTGAATCTAGGCCACCAGGCTCTCTTCCAGGAGAAGGTCATCAGGACTTTGGATTTTTCC 
               
               
                   
               
               
                 ACACCGGGGCGCATTGCAGCCGCGGTTGCTTTTCTAGCTTTTTTGAAGGATAGATGGAGCGAAGAGA 
               
               
                   
               
               
                 CCCACTTGAGTTCGGGCTACGTCCTGGATTTTCTGGCCATGCAACTGTGGAGAGCATGGATCAGACA 
               
               
                   
               
               
                 CAAGAACAGGCTGCAACTGTTGTCTTCCGTCCGCCCGTTGCTGATTCCGGCGGAGGAGCAACAGGCC 
               
               
                   
               
               
                 GGGTCAGAGGACCGGGCCCGTCGGGATCCGGAGGAGAGGGCACCGAGGCCGGGCGAGAGGAGCGC 
               
               
                   
               
               
                 GCTGAACCTGGGAACCGGGCTGAGCGGCCATCCACATCGGGAGTGAATGTCGGGCAGGTGGTGGAT 
               
               
                   
               
               
                 CTTTTTCCAGAACTGCGGCGGATTTTGACTATTAGGGAGGATGGGCAATTTGTTAAGGGTCTTAAGAG 
               
               
                   
               
               
                 GGAGAGGGGGGCTTCTGAGCATAACGAGGAGGCCAGTAATTTAGCTTTTAGCTTGATGACCAGACAC 
               
               
                   
               
               
                 CGTCCAGAGTGCATCACTTTTCAGCAGATTAAGGACAATTGTGCCAATGAGTTGGATCTGTTGGGTCA 
               
               
                   
               
               
                 GAAGTATAGCATAGAGCAGCTGACCACTTACTGGCTGCAGCCGGGTGATGATCTGGAGGAAGCTATT 
               
               
                   
               
               
                 AGGGTGTATGCTAAGGTGGCCCTGCGGCCCGATTGCAAGTACAAGCTCAAGGGGCTGGTGAATATCA 
               
               
                   
               
               
                 GGAATTGTTGCTACATTTCTGGCAACGGGGCGGAGGTGGAGATAGAGACCGAAGACAGGGTGGCTTT 
               
               
                   
               
               
                 CAGATGCAGCATGATGAATATGTGGCCGGGGGTGCTGGGCATGGACGGGGTGGTGATTATGAATGTG 
               
               
                   
               
               
                 AGGTTCACGGGGCCCAACTTTAACGGCACGGTGTTTTTGGGGAACACCAACCTGGTCCTGCACGGGG 
               
               
                   
               
               
                 TGAGCTTCTATGGGTTTAACAACACCTGTGTGGAGGCCTGGACCGATGTGAAGGTCCGCGGTTGCGC 
               
               
                   
               
               
                 CTTTTATGGATGTTGGAAGGCCATAGTGAGCCGCCCTAAGAGCAGGAGTTCCATTAAGAAATGCTTG 
               
               
                   
               
               
                 TTTGAGAGGTGCACCTTGGGGATCCTGGCCGAGGGCAACTGCAGGGTGCGCCACAATGTGGCCTCCG 
               
               
                   
               
               
                 AGTGCGGTTGCTTCATGCTAGTCAAGAGCGTGGCGGTAATCAAGCATAATATGGTGTGCGGCAACAG 
               
               
                   
               
               
                 CGAGGACAAGGCCTCACAGATGCTGACCTGCACGGATGGCAACTGCCACTTGCTGAAGACCATCCAT 
               
               
                   
               
               
                 GTAACCAGCCACAGCCGGAAGGCCTGGCCCGTGTTCGAGCACAACTTGCTGACCCGCTGCTCCTTGC 
               
               
                   
               
               
                 ATCTGGGCAACAGGCGGGGGGTGTTCCTGCCCTATCAATGCAACTTTAGTCACACCAAGATCTTGCT 
               
               
                   
               
               
                 AGAGCCCGAGAGCATGTCCAAGGTGAACTTGAACGGGGTGTTTGACATGACCATGAAGATCTGGAA 
               
               
                   
               
               
                 GGTGCTGAGGTACGACGAGACCAGGTCCCGGTGCAGACCCTGCGAGTGCGGGGGCAAGCATATGAG 
               
               
                   
               
               
                 GAACCAGCCCGTGATGCTGGATGTGACCGAGGAGCTGAGGACAGACCACTTGGTTCTGGCCTGCACC 
               
               
                   
               
               
                 AGGGCCGAGTTTGGTTCTAGCGATGAAGACACAGATTGAGGTGGGTGAGTGGGCGTGGCCTGGGGT 
               
               
                   
               
               
                 GGTCATGAAAATATATAAGTTGGGGGTCTTAGGGTCTCTTTATTTGTGTTGCAGAGACCGCCGGAGCC 
               
               
                   
               
               
                 ATGAGCGGGAGCAGCAGCAGCAGCAGTAGCAGCAGCGCCTTGGATGGCAGCATCGTGAGCCCTTAT 
               
               
                   
               
               
                 TTGACGACGCGGATGCCCCACTGGGCCGGGGTGCGTCAGAATGTGATGGGCTCCAGCATCGACGGCC 
               
               
                   
               
               
                 GACCCGTCCTGCCCGCAAATTCCGCCACGCTGACCTATGCGACCGTCGCGGGGACGCCGTTGGACGC 
               
               
                   
               
               
                 CACCGCCGCCGCCGCCGCCACCGCAGCCGCCTCGGCCGTGCGCAGCCTGGCCACGGACTTTGCATTC 
               
               
                   
               
               
                 CTGGGACCACTGGCGACAGGGGCTACTTCTCGGGCCGCTGCTGCCGCCGTTCGCGATGACAAGCTGA 
               
               
                   
               
               
                 CCGCCCTGCTGGCGCAGTTGGATGCGCTTACTCGGGAACTGGGTGACCTTTCTCAGCAGGTCATGGCC 
               
               
                   
               
               
                 CTGCGCCAGCAGGTCTCCTCCCTGCAAGCTGGCGGGAATGCTTCTCCCACAAATGCCGTTTAAGATA 
               
               
                   
               
               
                 AATAAAACCAGACTCTGTTTGGATTAAAGAAAAGTAGCAAGTGCATTGCTCTCTTTATTTCATAATTT 
               
               
                   
               
               
                 TCCGCGCGCGATAGGCCCTAGACCAGCGTTCTCGGTCGTTGAGGGTGCGGTGTATCTTCTCCAGGAC 
               
               
                   
               
               
                 GTGGTAGAGGTGGCTCTGGACGTTGAGATACATGGGCATGAGCCCGTCCCGGGGGTGGAGGTAGCA 
               
               
                   
               
               
                 CCACTGCAGAGCTTCATGCTCCGGGGTGGTGTTGTAGATGATCCAGTCGTAGCAGGAGCGCTGGGCA 
               
               
                   
               
               
                 TGGTGCCTAAAAATGTCCTTCAGCAGCAGGCCGATGGCCAGGGGGAGGCCCTTGGTGTAAGTGTTTA 
               
               
                   
               
               
                 CAAAACGGTTAAGTTGGGAAGGGTGCATTCGGGGAGAGATGATGTGCATCTTGGACTGTATTTTTAG 
               
               
                   
               
               
                 ATTGGCGATGTTTCCGCCCAGATCCCTTCTGGGATTCATGTTGTGCAGGACCACCAGTACAGTGTATC 
               
               
                   
               
               
                 CGGTGCACTTGGGGAATTTGTCATGCAGCTTAGAGGGAAAAGCGTGGAAGAACTTGGAGACGCCTTT 
               
               
                   
               
               
                 GTGGCCTCCCAGATTTTCCATGCATTCGTCCATGATGATGGCAATGGGCCCGCGGGAGGCAGCTTGG 
               
               
                   
               
               
                 GCAAAGATATTTCTGGGGTCGCTGACGTCGTAGTTGTGTTCCAGGGTGAGGTCGTCATAGGCCATTTT 
               
               
                   
               
               
                 TACAAAGCGCGGGCGGAGGGTGCCCGACTGGGGGATGATGGTCCCCTCTGGCCCTGGGGCGTAGTTG 
               
               
                   
               
               
                 CCCTCGCAGATCTGCATTTCCCAGGCCTTAATCTCGGAGGGGGGAATCATATCCACCTGCGGGGCGA 
               
               
                   
               
               
                 TGAAGAAAACGGTTTCCGGAGCCGGGGAGATTAACTGGGATGAGAGCAGGTTTCTAAGCAGCTGTG 
               
               
                   
               
               
                 ATTTTCCACAACCGGTGGGCCCATAAATAACACCTATAACCGGTTGCAGCTGGTAGTTTAGAGAGCT 
               
               
                   
               
               
                 GCAGCTGCCGTCGTCCCGGAGGAGGGGGGCCACCTCGTTGAGCATGTCCCTGACGCGCATGTTCTCC 
               
               
                   
               
               
                 CCGACCAGATCCGCCAGAAGGCGCTCGCCGCCCAGGGACAGCAGCTCTTGCAAGGAAGCAAAGTTTT 
               
               
                   
               
               
                 TCAGCGGCTTGAGGCCGTCCGCCGTGGGCATGTTTTTCAGGGTCTGGCTCAGCAGCTCCAGGCGGTCC 
               
               
                   
               
               
                 CAGAGCTCGGTGACGTGCTCTACGGCATCTCTATCCAGCATATCTCCTCGTTTCGCGGGTTGGGGCGA 
               
               
                   
               
               
                 CTTTCGCTGTAGGGCACCAAGCGGTGGTCGTCCAGCGGGGCCAGAGTCATGTCCTTCCATGGGCGCA 
               
               
                   
               
               
                 GGGTCCTCGTCAGGGTGGTCTGGGTCACGGTGAAGGGGTGCGCTCCGGGCTGAGCGCTTGCCAAGGT 
               
               
                   
               
               
                 GCGCTTGAGGCTGGTTCTGCTGGTGCTGAAGCGCTGCCGGTCTTCGCCCTGCGCGTCGGCCAGGTAGC 
               
               
                   
               
               
                 ATTTGACCATGGTGTCATAGTCCAGCCCCTCCGCGGCGTGTCCCTTGGCGCGCAGCTTGCCCTTGGAG 
               
               
                   
               
               
                 GTGGCGCCGCACGAGGGGCAGAGCAGGCTCTTGAGCGCGTAGAGCTTGGGGGCGAGGAAGACCGAT 
               
               
                   
               
               
                 TCGGGGGAGTAGGCGTCCGCGCCGCAGACCCCGCACACGGTCTCGCACTCCACCAGCCAGGTGAGCT 
               
               
                   
               
               
                 CGGGGCGCGCCGGGTCAAAAACCAGGTTTCCCCCATGCTTTTTGATGCGTTTCTTACCTCGGGTCTCC 
               
               
                   
               
               
                 ATGAGGTGGTGTCCCCGCTCGGTGACGAAGAGGCTGTCCGTGTCTCCGTAGACCGACTTGAGGGGTC 
               
               
                   
               
               
                 TTTTCTCCAGGGGGGTCCCTCGGTCTTCCTCGTAGAGGAACTCGGACCACTCTGAGACGAAGGCCCG 
               
               
                   
               
               
                 CGTCCAGGCCAGGACGAAGGAGGCTATGTGGGAGGGGTAGCGGTCGTTGTCCACTAGGGGGTCCAC 
               
               
                   
               
               
                 CTTCTCCAAGGTGTGAAGACACATGTCGCCTTCCTCGGCGTCCAGGAAGGTGATTGGCTTGTAGGTGT 
               
               
                   
               
               
                 AGGCCACGTGACCGGGGGTTCCTGACGGGGGGGTATAAAAGGGGGTGGGGGCGCGCTCGTCGTCAC 
               
               
                   
               
               
                 TCTCTTCCGCATCGCTGTCTGCGAGGGCCAGCTGCTGGGGTGAGTATTCCCTCTCGAAGGCGGGCATG 
               
               
                   
               
               
                 ACCTCCGCGCTGAGGTTGTCAGTTTCCAAAAACGAGGAGGATTTGATGTTCACCTGTCCCGAGGTGA 
               
               
                   
               
               
                 TACCTTTGAGGGTACCCGCGTCCATCTGGTCAGAAAACACGATCTTTTTATTGTCCAGCTTGGTGGCG 
               
               
                   
               
               
                 AACGACCCGTAGAGGGCGTTGGAGAGCAGCTTGGCGATGGAGCGCAGGGTCTGGTTCTTGTCCCTGT 
               
               
                   
               
               
                 CGGCGCGCTCCTTGGCCGCGATGTTGAGCTGCACGTACTCGCGCGCGACGCAGCGCCACTCGGGGAA 
               
               
                   
               
               
                 GACGGTGGTGCGCTCGTCGGGCACCAGGCGCACGCGCCAGCCGCGGTTGTGCAGGGTGACCAGGTCC 
               
               
                   
               
               
                 ACGCTGGTGGCGACCTCGCCGCGCAGGCGCTCGTTGGTCCAGCAGAGACGGCCGCCCTTGCGCGAGC 
               
               
                   
               
               
                 AGAAGGGGGGCAGGGGGTCGAGCTGGGTCTCGTCCGGGGGGTCCGCGTCCACGGTGAAAACCCCGG 
               
               
                   
               
               
                 GGCGCAGGCGCGCGTCGAAGTAGTCTATCTTGCAACCTTGCATGTCCAGCGCCTGCTGCCAGTCGCG 
               
               
                   
               
               
                 GGCGGCGAGCGCGCGCTCGTAGGGGTTGAGCGGCGGGCCCCAGGGCATGGGGTGGGTGAGTGCGGA 
               
               
                   
               
               
                 GGCGTACATGCCGCAGATGTCATAGACGTAGAGGGGCTCCCGCAGGACCCCGATGTAGGTGGGGTA 
               
               
                   
               
               
                 GCAGCGGCCGCCGCGGATGCTGGCGCGCACGTAGTCATACAGCTCGTGCGAGGGGGCGAGGAGGTC 
               
               
                   
               
               
                 GGGGCCCAGGTTGGTGCGGGCGGGGCGCTCCGCGCGGAAGACGATCTGCCTGAAGATGGCATGCGA 
               
               
                   
               
               
                 GTTGGAAGAGATGGTGGGGCGCTGGAAGACGTTGAAGCTGGCGTCCTGCAGGCCGACGGCGTCGCG 
               
               
                   
               
               
                 CACGAAGGAGGCGTAGGAGTCGCGCAGCTTGTGTACCAGCTCGGCGGTGACCTGCACGTCGAGCGC 
               
               
                   
               
               
                 GCAGTAGTCGAGGGTCTCGCGGATGATGTCATATTTAGCCTGCCCCTTCTTTTTCCACAGCTCGCGGT 
               
               
                   
               
               
                 TGAGGACAAACTCTTCGCGGTCTTTCCAGTACTCTTGGATCGGGAAACCGTCCGGTTCCGAACGGTA 
               
               
                   
               
               
                 AGAGCCTAGCATGTAGAACTGGTTGACGGCCTGGTAGGCGCAGCAGCCCTTCTCCACGGGGAGGGCG 
               
               
                   
               
               
                 TAGGCCTGCGCGGCCTTGCGGAGCGAGGTGTGGGTCAGGGCGAAGGTGTCCCTGACCATGACTTTGA 
               
               
                   
               
               
                 GGTACTGGTGCTTGAAGTCGGAGTCGTCGCAGCCGCCCCGCTCCCAGAGCGAGAAGTCGGTGCGCTT 
               
               
                   
               
               
                 CTTGGAGCGGGGGTTGGGCAGAGCGAAGGTGACATCGTTGAAGAGGATTTTGCCCGCGCGGGGCAT 
               
               
                   
               
               
                 GAAGTTGCGGGTGATGCGGAAGGGCCCCGGCACTTCAGAGCGGTTGTTGATGACCTGGGCGGCGAG 
               
               
                   
               
               
                 CACGATCTCGTCGAAGCCGTTGATGTTGTGGCCCACGATGTAGAGTTCCAGGAAGCGGGGCCGGCCC 
               
               
                   
               
               
                 TTTACGGTGGGCAGCTTCTTTAGCTCTTCGTAGGTGAGCTCCTCGGGCGAGGCGAGGCCGTGCTCGGC 
               
               
                   
               
               
                 CAGGGCCCAGTCCGCGAGGTGCGGGTTGTCTCTGAGGAAGGACTTCCAGAGGTCGCGGGCCAGGAG 
               
               
                   
               
               
                 GGTCTGCAGGCGGTCTCTGAAGGTCCTGAACTGGCGGCCCACGGCCATTTTTTCGGGGGTGATGCAG 
               
               
                   
               
               
                 TAGAAGGTGAGGGGGTCTTGCTGCCAGCGGTCCCAGTCGAGCTGCAGGGCGAGGTCGCGCGCGGCG 
               
               
                   
               
               
                 GTGACCAGGCGCTCGTCGCCCCCGAATTTCATGACCAGCATGAAGGGCACGAGCTGCTTTCCGAAGG 
               
               
                   
               
               
                 CCCCCATCCAAGTGTAGGTCTCTACATCGTAGGTGACAAAGAGGCGCTCCGTGCGAGGATGCGAGCC 
               
               
                   
               
               
                 GATCGGGAAGAACTGGATCTCCCGCCACCAGTTGGAGGAGTGGCTGTTGATGTGGTGGAAGTAGAA 
               
               
                   
               
               
                 GTCCCGTCGCCGGGCCGAACACTCGTGCTGGCTTTTGTAAAAGCGAGCGCAGTACTGGCAGCGCTGC 
               
               
                   
               
               
                 ACGGGCTGTACCTCATGCACGAGATGCACCTTTCGCCCGCGCACGAGGAAGCCGAGGGGAAATCTGA 
               
               
                   
               
               
                 GCCCCCCGCCTGGCTCGCGGCATGGCTGGTTCTCTTCTACTTTGGATGCGTGTCCGTCTCCGTCTGGCT 
               
               
                   
               
               
                 CCTCGAGGGGTGTTACGGTGGAGCGGACCACCACGCCGCGCGAGCCGCAGGTCCAGATATCGGCGC 
               
               
                   
               
               
                 GCGGCGGTCGGAGTTTGATGACGACATCGCGCAGCTGGGAGCTGTCCATGGTCTGGAGCTCCCGCGG 
               
               
                   
               
               
                 CGGCGGCAGGTCAGCCGGGAGTTCTTGCAGGTTCACCTCGCAGAGTCGGGCCAGGGCGCGGGGCAG 
               
               
                   
               
               
                 GTCTAGGTGGTACCTGATCTCTAGGGGCGTGTTGGTGGCGGCGTCGATGGCTTGCAGGAGCCCGCAG 
               
               
                   
               
               
                 CCCCGGGGGGCGACGACGGTGCCCCGCGGGGTGGTGGTGGTGGTGGCGGTGCAGCTCAGAAGCGGT 
               
               
                   
               
               
                 GCCGCGGGCGGGCCCCCGGAGGTAGGGGGGGCTCCGGTCCCGCGGGCAGGGGCGGCAGCGGCACGT 
               
               
                   
               
               
                 CGGCGTGGAGCGCGGGCAGGAGTTGGTGCTGTGCCCGGAGGTTGCTGGCGAAGGCGACGACGCGGC 
               
               
                   
               
               
                 GGTTGATCTCCTGGATCTGGCGCCTCTGCGTGAAGACGACGGGCCCGGTGAGCTTGAACCTGAAAGA 
               
               
                   
               
               
                 GAGTTCGACAGAATCAATCTCGGTGTCATTGACCGCGGCCTGGCGCAGGATCTCCTGCACGTCTCCC 
               
               
                   
               
               
                 GAGTTGTCTTGGTAGGCGATCTCGGCCATGAACTGCTCGATCTCTTCCTCCTGGAGGTCTCCGCGTCC 
               
               
                   
               
               
                 GGCGCGTTCCACGGTGGCCGCCAGGTCGTTGGAGATGCGCCCCATGAGCTGCGAGAAGGCGTTGAGT 
               
               
                   
               
               
                 CCGCCCTCGTTCCAGACTCGGCTGTAGACCACGCCCCCCTGGTCATCGCGGGCGCGCATGACCACCT 
               
               
                   
               
               
                 GCGCGAGGTTGAGCTCCACGTGCCGCGCGAAGACGGCGTAGTTGCGCAGACGCTGGAAGAGGTAGT 
               
               
                   
               
               
                 TGAGGGTGGTGGCGGTGTGCTCGGCCACGAAGAAGTTCATGACCCAGCGGCGCAACGTGGATTCGTT 
               
               
                   
               
               
                 GATGTCCCCCAAGGCCTCCAGCCGTTCCATGGCCTCGTAGAAGTCCACGGCGAAGTTGAAAAACTGG 
               
               
                   
               
               
                 GAGTTGCGCGCCGACACGGTCAACTCCTCCTCCAGAAGACGGATGAGCTCGGCGACGGTGTCGCGCA 
               
               
                   
               
               
                 CCTCGCGCTCGAAGGCTATGGGGATCTCTTCCTCCGCTAGCATCACCACCTCCTCCTCTTCCTCCTCTT 
               
               
                   
               
               
                 CTGGCACTTCCATGATGGCTTCCTCCTCTTCGGGGGGTGGCGGCGGCGGCGGTGGGGGAGGGGGCGC 
               
               
                   
               
               
                 TCTGCGCCGGCGGCGGCGCACCGGGAGGCGGTCCACGAAGCGCGCGATCATCTCCCCGCGGCGGCG 
               
               
                   
               
               
                 GCGCATGGTCTCGGTGACGGCGCGGCCGTTCTCCCGGGGGCGCAGTTGGAAGACGCCGCCGGACATC 
               
               
                   
               
               
                 TGGTGCTGGGGCGGGTGGCCGTGAGGCAGCGAGACGGCGCTGACGATGCATCTCAACAATTGCTGCG 
               
               
                   
               
               
                 TAGGTACGCCGCCGAGGGACCTGAGGGAGTCCATATCCACCGGATCCGAAAACCTTTCGAGGAAGG 
               
               
                   
               
               
                 CGTCTAACCAGTCGCAGTCGCAAGGTAGGCTGAGCACCGTGGCGGGCGGCGGGGGGTGGGGGGAGT 
               
               
                   
               
               
                 GTCTGGCGGAGGTGCTGCTGATGATGTAATTGAAGTAGGCGGACTTGACACGGCGGATGGTCGACAG 
               
               
                   
               
               
                 GAGCACCATGTCCTTGGGTCCGGCCTGCTGGATGCGGAGGCGGTCGGCTATGCCCCAGGCTTCGTTCT 
               
               
                   
               
               
                 GGCATCGGCGCAGGTCCTTGTAGTAGTCTTGCATGAGCCTTTCCACCGGCACCTCTTCTCCTTCCTCTT 
               
               
                   
               
               
                 CTGCTTCTTCCATGTCTGCTTCGGCCCTGGGGCGGCGCCGCGCCCCCCTGCCCCCCATGCGCGTGACC 
               
               
                   
               
               
                 CCGAACCCCCTGAGCGGTTGGAGCAGGGCCAGGTCGGCGACGACGCGCTCGGCCAGGATGGCCTGC 
               
               
                   
               
               
                 TGCACCTGCGTGAGGGTGGTTTGGAAGTCATCCAAGTCCACGAAGCGGTGGTAGGCGCCCGTGTTGA 
               
               
                   
               
               
                 TGGTGTAGGTGCAGTTGGCCATGACGGACCAGTTGACGGTCTGGTGGCCCGGTTGCGACATCTCGGT 
               
               
                   
               
               
                 GTACCTGAGTCGCGAGTAGGCGCGGGAGTCGAAGACGTAGTCGTTGCAAGTCCGCACCAGGTACTGG 
               
               
                   
               
               
                 TAGCCCACCAGGAAGTGCGGCGGCGGCTGGCGGTAGAGGGGCCAGCGCAGGGTGGCGGGGGCTCCG 
               
               
                   
               
               
                 GGGGCCAGGTCTTCCAGCATGAGGCGGTGGTAGGCGTAGATGTACCTGGACATCCAGGTGATACCCG 
               
               
                   
               
               
                 CGGCGGTGGTGGAGGCGCGCGGGAAGTCGCGCACCCGGTTCCAGATGTTGCGCAGGGGCAGAAAGT 
               
               
                   
               
               
                 GCTCCATGGTAGGCGTGCTCTGTCCAGTCAGACGCGCGCAGTCGTTGATACTCTAGACCAGGGAAAA 
               
               
                   
               
               
                 CGAAAGCCGGTCAGCGGGCACTCTTCCGTGGTCTGGTGAATAGATCGCAAGGGTATCATGGCGGAGG 
               
               
                   
               
               
                 GCCTCGGTTCGAGCCCCGGGTCCGGGCCGGACGGTCCGCCATGATCCACGCGGTTACCGCCCGCGTG 
               
               
                   
               
               
                 TCGAACCCAGGTGTGCGACGTCAGACAACGGTGGAGTGTTCCTTTTGGCGTTTTTCTGGCCGGGCGCC 
               
               
                   
               
               
                 GGCGCCGCGTAAGAGACTAAGCCGCGAAAGCGAAAGCAGTAAGTGGCTCGCTCCCCGTAGCCGGAG 
               
               
                   
               
               
                 GGATCCTTGCTAAGGGTTGCGTTGCGGCGAACCCCGGTTCGAATCCCGTACTCGGGCCGGCCGGACC 
               
               
                   
               
               
                 CGCGGCTAAGGTGTTGGATTGGCCTCCCCCTCGTATAAAGACCCCGCTTGCGGATTGACTCCGGACA 
               
               
                   
               
               
                 CGGGGACGAGCCCCTTTTATTTTTGCTTTCCCCAGATGCATCCGGTGCTGCGGCAGATGCGCCCCCCG 
               
               
                   
               
               
                 CCCCAGCAGCAGCAACAACACCAGCAAGAGCGGCAGCAACAGCAGCGGGAGTCATGCAGGGCCCCC 
               
               
                   
               
               
                 TCACCCACCCTCGGCGGGCCGGCCACCTCGGCGTCCGCGGCCGTGTCTGGCGCCTGCGGCGGCGGCG 
               
               
                   
               
               
                 GGGGGCCGGCTGACGACCCCGAGGAGCCCCCGCGGCGCAGGGCCAGACACTACCTGGACCTGGAGG 
               
               
                   
               
               
                 AGGGCGAGGGCCTGGCGCGGCTGGGGGCGCCGTCTCCCGAGCGCCACCCGCGGGTGCAGCTGAAGC 
               
               
                   
               
               
                 GCGACTCGCGCGAGGCGTACGTGCCTCGGCAGAACCTGTTCAGGGACCGCGCGGGCGAGGAGCCCG 
               
               
                   
               
               
                 AGGAGATGCGGGACAGGAGGTTCAGCGCAGGGCGGGAGCTGCGGCAGGGGCTGAACCGCGAGCGG 
               
               
                   
               
               
                 CTGCTGCGCGAGGAGGACTTTGAGCCCGACGCGCGGACGGGGATCAGCCCCGCGCGCGCGCACGTG 
               
               
                   
               
               
                 GCGGCCGCCGACCTGGTGACGGCGTACGAGCAGACGGTGAACCAGGAGATCAACTTCCAAAAGAGT 
               
               
                   
               
               
                 TTCAACAACCACGTGCGCACGCTGGTGGCGCGCGAGGAGGTGACCATCGGGCTGATGCACCTGTGGG 
               
               
                   
               
               
                 ACTTTGTAAGCGCGCTGGTGCAGAACCCCAACAGCAAGCCTCTGACGGCGCAGCTGTTCCTGATAGT 
               
               
                   
               
               
                 GCAGCACAGCAGGGACAACGAGGCGTTTAGGGACGCGCTGCTGAACATCACCGAGCCCGAGGGTCG 
               
               
                   
               
               
                 GTGGCTGCTGGACCTGATTAACATCCTGCAGAGCATAGTGGTGCAGGAGCGCAGCCTGAGCCTGGCC 
               
               
                   
               
               
                 GACAAGGTGGCGGCCATCAACTACTCGATGCTGAGCCTGGGCAAGTTTTACGCGCGCAAGATCTACC 
               
               
                   
               
               
                 AGACGCCGTACGTGCCCATAGACAAGGAGGTGAAGATCGACGGTTTTTACATGCGCATGGCGCTGAA 
               
               
                   
               
               
                 GGTGCTCACCCTGAGCGACGACCTGGGCGTGTACCGCAACGAGCGCATCCACAAGGCCGTGAGCGTG 
               
               
                   
               
               
                 AGCCGGCGGCGCGAGCTGAGCGACCGCGAGCTGATGCACAGCCTGCAGCGGGCGCTGGCGGGCGCC 
               
               
                   
               
               
                 GGCAGCGGCGACAGGGAGGCGGAGTCCTACTTCGATGCGGGGGCGGACCTGCGCTGGGCGCCCAGC 
               
               
                   
               
               
                 CGGCGGGCCCTGGAGGCCGCGGGGGTCCGCGAGGACTATGACGAGGACGGCGAGGAGGATGAGGA 
               
               
                   
               
               
                 GTACGAGCTAGAGGAGGGCGAGTACCTGGACTAAACCGCGGGTGGTGTTTCCGGTAGATGCAAGAC 
               
               
                   
               
               
                 CCGAACGTGGTGGACCCGGCGCTGCGGGCGGCTCTGCAGAGCCAGCCGTCCGGCCTTAACTCCTCAG 
               
               
                   
               
               
                 ACGACTGGCGACAGGTCATGGACCGCATCATGTCGCTGACGGCGCGTAACCCGGACGCGTTCCGGCA 
               
               
                   
               
               
                 GCAGCCGCAGGCCAACAGGCTCTCCGCCATCCTGGAGGCGGTGGTGCCTGCGCGCTCGAACCCCACG 
               
               
                   
               
               
                 CACGAGAAGGTGCTGGCCATAGTGAACGCGCTGGCCGAGAACAGGGCCATCCGCCCGGACGAGGCC 
               
               
                   
               
               
                 GGGCTGGTGTACGACGCGCTGCTGCAGCGCGTGGCCCGCTACAACAGCGGCAACGTGCAGACCAAC 
               
               
                   
               
               
                 CTGGACCGGCTGGTGGGGGACGTGCGCGAGGCGGTGGCGCAGCGCGAGCGCGCGGATCGGCAGGGC 
               
               
                   
               
               
                 AACCTGGGCTCCATGGTGGCGCTGAATGCCTTCCTGAGCACGCAGCCGGCCAACGTGCCGCGGGGGC 
               
               
                   
               
               
                 AGGAAGACTACACCAACTTTGTGAGCGCGCTGCGGCTGATGGTGACCGAGACCCCCCAGAGCGAGG 
               
               
                   
               
               
                 TGTACCAGTCGGGCCCGGACTACTTCTTCCAGACCAGCAGACAGGGCCTGCAGACGGTGAACCTGAG 
               
               
                   
               
               
                 CCAGGCTTTCAAGAACCTGCGGGGGCTGTGGGGCGTGAAGGCGCCCACCGGCGACCGGGCGACGGT 
               
               
                   
               
               
                 GTCCAGCCTGCTGACGCCCAACTCGCGCCTGCTGCTGCTGCTGATCGCGCCGTTCACGGACAGCGGC 
               
               
                   
               
               
                 AGCGTGTCCCGGGACACCTACCTGGGGCACCTGCTGACCCTGTACCGCGAGGCCATCGGGCAGGCGC 
               
               
                   
               
               
                 AGGTGGACGAGCACACCTTCCAGGAGATCACCAGCGTGAGCCGCGCGCTGGGGCAGGAGGACACGA 
               
               
                   
               
               
                 GCAGCCTGGAGGCGACTCTGAACTACCTGCTGACCAACCGGCGGCAGAAGATTCCCTCGCTGCACAG 
               
               
                   
               
               
                 CCTGACCTCCGAGGAGGAGCGCATCTTGCGCTACGTGCAGCAGAGCGTGAGCCTGAACCTGATGCGC 
               
               
                   
               
               
                 GACGGGGTGACGCCCAGCGTGGCGCTGGACATGACCGCGCGCAACATGGAACCGGGCATGTACGCC 
               
               
                   
               
               
                 GCGCACCGGCCTTACATCAACCGCCTGATGGACTACCTGCATCGCGCGGCGGCCGTGAACCCCGAGT 
               
               
                   
               
               
                 ACTTTACCAACGCCATCCTGAACCCGCACTGGCTCCCGCCGCCCGGGTTCTACAGCGGGGGCTTCGA 
               
               
                   
               
               
                 GGTCCCGGAGACCAACGATGGCTTCCTGTGGGACGACATGGACGACAGCGTGTTCTCCCCGCGGCCG 
               
               
                   
               
               
                 CAGGCGCTGGCGGAAGCGTCCCTGCTGCGTCCCAAGAAGGAGGAGGAGGAGGAGGCGAGTCGCCGC 
               
               
                   
               
               
                 CGCGGCAGCAGCGGCGTGGCTTCTCTGTCCGAGCTGGGGGCGGCAGCCGCCGCGCGCCCCGGGTCCC 
               
               
                   
               
               
                 TGGGCGGCAGCCCCTTTCCGAGCCTGGTGGGGTCTCTGCACAGCGAGCGCACCACCCGCCCTCGGCT 
               
               
                   
               
               
                 GCTGGGCGAGGACGAGTACCTGAATAACTCCCTGCTGCAGCCGGTGCGGGAGAAAAACCTGCCTCCC 
               
               
                   
               
               
                 GCCTTCCCCAACAACGGGATAGAGAGCCTGGTGGACAAGATGAGCAGATGGAAGACCTATGCGCAG 
               
               
                   
               
               
                 GAGCACAGGGACGCGCCTGCGCTCCGGCCGCCCACGCGGCGCCAGCGCCACGACCGGCAGCGGGGG 
               
               
                   
               
               
                 CTGGTGTGGGATGACGAGGACTCCGCGGACGATAGCAGCGTGCTGGACCTGGGAGGGAGCGGCAAC 
               
               
                   
               
               
                 CCGTTCGCGCACCTGCGCCCCCGCCTGGGGAGGATGTTTTAAAAAAAAAAAAAAAAAGCAAGAAGC 
               
               
                   
               
               
                 ATGATGCAAAAATTAAATAAAACTCACCAAGGCCATGGCGACCGAGCGTTGGTTTCTTGTGTTCCCTT 
               
               
                   
               
               
                 CAGTATGCGGCGCGCGGCGATGTACCAGGAGGGACCTCCTCCCTCTTACGAGAGCGTGGTGGGCGCG 
               
               
                   
               
               
                 GCGGCGGCGGCGCCCTCTTCTCCCTTTGCGTCGCAGCTGCTGGAGCCGCCGTACGTGCCTCCGCGCTA 
               
               
                   
               
               
                 CCTGCGGCCTACGGGGGGGAGAAACAGCATCCGTTACTCGGAGCTGGCGCCCCTGTTCGACACCACC 
               
               
                   
               
               
                 CGGGTGTACCTGGTGGACAACAAGTCGGCGGACGTGGCCTCCCTGAACTACCAGAACGACCACAGC 
               
               
                   
               
               
                 AATTTTTTGACCACGGTCATCCAGAACAATGACTACAGCCCGAGCGAGGCCAGCACCCAGACCATCA 
               
               
                   
               
               
                 ATCTGGATGACCGGTCGCACTGGGGCGGCGACCTGAAAACCATCCTGCACACCAACATGCCCAACGT 
               
               
                   
               
               
                 GAACGAGTTCATGTTCACCAATAAGTTCAAGGCGCGGGTGATGGTGTCGCGCTCGCACACCAAGGAA 
               
               
                   
               
               
                 GACCGGGTGGAGCTGAAGTACGAGTGGGTGGAGTTCGAGCTGCCAGAGGGCAACTACTCCGAGACC 
               
               
                   
               
               
                 ATGACCATTGACCTGATGAACAACGCGATCGTGGAGCACTATCTGAAAGTGGGCAGGCAGAACGGG 
               
               
                   
               
               
                 GTCCTGGAGAGCGACATCGGGGTCAAGTTCGACACCAGGAACTTCCGCCTGGGGCTGGACCCCGTGA 
               
               
                   
               
               
                 CCGGGCTGGTTATGCCCGGGGTGTACACCAACGAGGCCTTCCATCCCGACATCATCCTGCTGCCCGG 
               
               
                   
               
               
                 CTGCGGGGTGGACTTCACTTACAGCCGCCTGAGCAACCTCCTGGGCATCCGCAAGCGGCAGCCCTTC 
               
               
                   
               
               
                 CAGGAGGGCTTCAGGATCACCTACGAGGACCTGGAGGGGGGCAACATCCCCGCGCTCCTCGATGTGG 
               
               
                   
               
               
                 AGGCCTACCAGGATAGCTTGAAGGAAAATGAGGCGGGACAGGAGGATACCGCCCCCGCCGCCTCCG 
               
               
                   
               
               
                 CCGCCGCCGAGCAGGGCGAGGATGCTGCTGACACCGCGGCCGCGGACGGGGCAGAGGCCGACCCCG 
               
               
                   
               
               
                 CTATGGTGGTGGAGGCTCCCGAGCAGGAGGAGGACATGAATGACAGTGCGGTGCGCGGAGACACCT 
               
               
                   
               
               
                 TCGTCACCCGGGGGGAGGAAAAGCAAGCGGAGGCCGAGGCCGCGGCCGAGGAAAAGCAACTGGCG 
               
               
                   
               
               
                 GCAGCAGCGGCGGCGGCGGCGTTGGCCGCGGCGGAGGCTGAGTCTGAGGGGACCAAGCCCGCCAAG 
               
               
                   
               
               
                 GAGCCCGTGATTAAGCCCCTGACCGAAGATAGCAAGAAGCGCAGTTACAACCTGCTCAAGGACAGC 
               
               
                   
               
               
                 ACCAACACCGCGTACCGCAGCTGGTACCTGGCCTACAACTACGGCGACCCGTCGACGGGGGTGCGCT 
               
               
                   
               
               
                 CCTGGACCCTGCTGTGCACGCCGGACGTGACCTGCGGCTCGGAGCAGGTGTACTGGTCGCTGCCCGA 
               
               
                   
               
               
                 CATGATGCAAGACCCCGTGACCTTCCGCTCCACGCGGCAGGTCAGCAACTTCCCGGTGGTGGGCGCC 
               
               
                   
               
               
                 GAGCTGCTGCCCGTGCACTCCAAGAGCTTCTACAACGACCAGGCCGTCTACTCCCAGCTCATCCGCC 
               
               
                   
               
               
                 AGTTCACCTCTCTGACCCACGTGTTCAATCGCTTTCCTGAGAACCAGATTCTGGCGCGCCCGCCCGCC 
               
               
                   
               
               
                 CCCACCATCACCACCGTCAGTGAAAACGTTCCTGCTCTCACAGATCACGGGACGCTACCGCTGCGCA 
               
               
                   
               
               
                 ACAGCATCGGAGGAGTCCAGCGAGTGACCGTTACTGACGCCAGACGCCGCACCTGCCCCTACGTTTA 
               
               
                   
               
               
                 CAAGGCCTTGGGCATAGTCTCGCCGCGCGTCCTTTCCAGCCGCACTTTTTGAGCAACACCACCATCAT 
               
               
                   
               
               
                 GTCCATCCTGATCTCACCCAGCAATAACTCCGGCTGGGGACTGCTGCGCGCGCCCAGCAAGATGTTC 
               
               
                   
               
               
                 GGAGGGGCGAGGAAGCGTTCCGAGCAGCACCCCGTGCGCGTGCGCGGGCACTTCCGCGCCCCCTGG 
               
               
                   
               
               
                 GGAGCGCACAAACGCGGCCGCGCGGGGCGCACCACCGTGGACGACGCCATCGACTCGGTGGTGGAG 
               
               
                   
               
               
                 CAGGCGCGCAACTACAGGCCCGCGGTCTCTACCGTGGACGCGGCCATCCAGACCGTGGTGCGGGGCG 
               
               
                   
               
               
                 CGCGGCGGTACGCCAAGCTGAAGAGCCGCCGGAAGCGCGTGGCCCGCCGCCACCGCCGCCGACCCG 
               
               
                   
               
               
                 GGGCCGCCGCCAAACGCGCCGCCGCGGCCCTGCTTCGCCGGGCCAAGCGCACGGGCCGCCGCGCCG 
               
               
                   
               
               
                 CCATGAGGGCCGCGCGCCGCTTGGCCGCCGGCATCACCGCCGCCACCATGGCCCCCCGTACCCGAAG 
               
               
                   
               
               
                 ACGCGCGGCCGCCGCCGCCGCCGCCGCCATCAGTGACATGGCCAGCAGGCGCCGGGGCAACGTGTA 
               
               
                   
               
               
                 CTGGGTGCGCGACTCGGTGACCGGCACGCGCGTGCCCGTGCGCTTCCGCCCCCCGCGGACTTGAGAT 
               
               
                   
               
               
                 GATGTGAAAAAACAACACTGAGTCTCCTGCTGTTGTGTGTATCCCAGCGGCGGCGGCGCGCGCAGCG 
               
               
                   
               
               
                 TCATGTCCAAGCGCAAAATCAAAGAAGAGATGCTCCAGGTCGTCGCGCCGGAGATCTATGGGCCCCC 
               
               
                   
               
               
                 GAAGAAGGAAGAGCAGGATTCGAAGCCCCGCAAGATAAAGCGGGTCAAAAAGAAAAAGAAAGATG 
               
               
                   
               
               
                 ATGACGATGCCGATGGGGAGGTGGAGTTCCTGCGCGCCACGGCGCCCAGGCGCCCGGTGCAGTGGA 
               
               
                   
               
               
                 AGGGCCGGCGCGTAAAGCGCGTCCTGCGCCCCGGCACCGCGGTGGTCTTCACGCCCGGCGAGCGCTC 
               
               
                   
               
               
                 CACCCGGACTTTCAAGCGCGTCTATGACGAGGTGTACGGCGACGAAGACCTGCTGGAGCAGGCCAAC 
               
               
                   
               
               
                 GAGCGCTTCGGAGAGTTTGCTTACGGGAAGCGTCAGCGGGCGCTGGGGAAGGAGGACCTGCTGGCG 
               
               
                   
               
               
                 CTGCCGCTGGACCAGGGCAACCCCACCCCCAGTCTGAAGCCCGTGACCCTGCAGCAGGTGCTGCCGA 
               
               
                   
               
               
                 GCAGCGCACCCTCCGAGGCGAAGCGGGGTCTGAAGCGCGAGGGCGGCGACCTGGCGCCCACCGTGC 
               
               
                   
               
               
                 AGCTCATGGTGCCCAAGCGGCAGAGGCTGGAGGATGTGCTGGAGAAAATGAAAGTAGACCCCGGTC 
               
               
                   
               
               
                 TGCAGCCGGACATCAGGGTCCGCCCCATCAAGCAGGTGGCGCCGGGCCTCGGCGTGCAGACCGTGG 
               
               
                   
               
               
                 ACGTGGTCATCCCCACCGGCAACTCCCCCGCCGCCGCCACCACTACCGCTGCCTCCACGGACATGGA 
               
               
                   
               
               
                 GACACAGACCGATCCCGCCGCAGCCGCAGCCGCAGCCGCCGCCGCGACCTCCTCGGCGGAGGTGCA 
               
               
                   
               
               
                 GACGGACCCCTGGCTGCCGCCGGCGATGTCAGCTCCCCGCGCGCGTCGCGGGCGCAGGAAGTACGGC 
               
               
                   
               
               
                 GCCGCCAACGCGCTCCTGCCCGAGTACGCCTTGCATCCTTCCATCGCGCCCACCCCCGGCTACCGAGG 
               
               
                   
               
               
                 CTATACCTACCGCCCGCGAAGAGCCAAGGGTTCCACCCGCCGTCCCCGCCGACGCGCCGCCGCCACC 
               
               
                   
               
               
                 ACCCGCCGCCGCCGCCGCAGACGCCAGCCCGCACTGGCTCCAGTCTCCGTGAGGAAAGTGGCGCGCG 
               
               
                   
               
               
                 ACGGACACACCCTGGTGCTGCCCAGGGCGCGCTACCACCCCAGCATCGTTTAAAAGCCTGTTGTGGT 
               
               
                   
               
               
                 TCTTGCAGATATGGCCCTCACTTGCCGCCTCCGTTTCCCGGTGCCGGGATACCGAGGAGGAAGATCG 
               
               
                   
               
               
                 CGCCGCAGGAGGGGTCTGGCCGGCCGCGGCCTGAGCGGAGGCAGCCGCCGCGCGCACCGGCGGCGA 
               
               
                   
               
               
                 CGCGCCACCAGCCGACGCATGCGCGGCGGGGTGCTGCCCCTGTTAATCCCCCTGATCGCCGCGGCGA 
               
               
                   
               
               
                 TCGGCGCCGTGCCCGGGATCGCCTCCGTGGCCTTGCAAGCGTCCCAGAGGCATTGACAGACTTGCAA 
               
               
                   
               
               
                 ACTTGCAAATATGGAAAAAAAAACCCCAATAAAAAAGTCTAGACTCTCACGCTCGCTTGGTCCTGTG 
               
               
                   
               
               
                 ACTATTTTGTAGAATGGAAGACATCAACTTTGCGTCGCTGGCCCCGCGTCACGGCTCGCGCCCGTTCC 
               
               
                   
               
               
                 TGGGACACTGGAACGATATCGGCACCAGCAACATGAGCGGTGGCGCCTTCAGTTGGGGCTCTCTGTG 
               
               
                   
               
               
                 GAGCGGCATTAAAAGTATCGGGTCTGCCGTTAAAAATTACGGCTCCCGGGCCTGGAACAGCAGCACG 
               
               
                   
               
               
                 GGCCAGATGTTGAGAGACAAGTTGAAAGAGCAGAACTTCCAGCAGAAGGTGGTGGAGGGCCTGGCC 
               
               
                   
               
               
                 TCCGGCATCAACGGGGTGGTGGACCTGGCCAACCAGGCCGTGCAGAATAAGATCAACAGCAGACTG 
               
               
                   
               
               
                 GACCCCCGGCCGCCGGTGGAGGAGGTGCCGCCGGCGCTGGAGACGGTGTCCCCCGATGGGCGTGGC 
               
               
                   
               
               
                 GAGAAGCGCCCGCGGCCCGATAGGGAAGAGACCACTCTGGTCACGCAGACCGATGAGCCGCCCCCG 
               
               
                   
               
               
                 TATGAGGAGGCCCTGAAGCAAGGTCTGCCCACCACGCGGCCCATCGCGCCCATGGCCACCGGGGTGG 
               
               
                   
               
               
                 TGGGCCGCCACACCCCCGCCACGCTGGACTTGCCTCCGCCCGCCGATGTGCCGCAGCAGCAGAAGGC 
               
               
                   
               
               
                 GGCACAGCCGGGCCCGCCCGCGACCGCCTCCCGTTCCTCCGCCGGTCCTCTGCGCCGCGCGGCCAGC 
               
               
                   
               
               
                 GGCCCCCGCGGGGGGGTCGCGAGGCACGGCAACTGGCAGAGCACGCTGAACAGCATCGTGGGTCTG 
               
               
                   
               
               
                 GGGGTGCGGTCCGTGAAGCGCCGCCGATGCTACTGAATAGCTTAGCTAACGTGTTGTATGTGTGTAT 
               
               
                   
               
               
                 GCGCCCTATGTCGCCGCCAGAGGAGCTGCTGAGTCGCCGCCGTTCGCGCGCCCACCACCACCGCCAC 
               
               
                   
               
               
                 TCCGCCCCTCAAGATGGCGACCCCATCGATGATGCCGCAGTGGTCGTACATGCACATCTCGGGCCAG 
               
               
                   
               
               
                 GACGCCTCGGAGTACCTGAGCCCCGGGCTGGTGCAGTTCGCCCGCGCCACCGAGAGCTACTTCAGCC 
               
               
                   
               
               
                 TGAGTAACAAGTTTAGGAACCCCACGGTGGCGCCCACGCACGATGTGACCACCGACCGGTCTCAGCG 
               
               
                   
               
               
                 CCTGACGCTGCGGTTCATTCCCGTGGACCGCGAGGACACCGCGTACTCGTACAAGGCGCGGTTCACC 
               
               
                   
               
               
                 CTGGCCGTGGGCGACAACCGCGTGCTGGACATGGCCTCCACCTACTTTGACATCCGCGGGGTGCTGG 
               
               
                   
               
               
                 ACCGGGGTCCCACTTTCAAGCCCTACTCTGGCACCGCCTACAACTCCCTGGCCCCCAAGGGCGCTCCC 
               
               
                   
               
               
                 AACTCCTGCGAGTGGGAGCAAGAGGAAACTCAGGCAGTTGAAGAAGCAGCAGAAGAGGAAGAAGA 
               
               
                   
               
               
                 AGATGCTGACGGTCAAGCTGAGGAAGAGCAAGCAGCTACCAAAAAGACTCATGTATATGCTCAGGC 
               
               
                   
               
               
                 TCCCCTTTCTGGCGAAAAAATTAGTAAAGATGGTCTGCAAATAGGAACGGACGCTACAGCTACAGAA 
               
               
                   
               
               
                 CAAAAACCTATTTATGCAGACCCTACATTCCAGCCCGAACCCCAAATCGGGGAGTCCCAGTGGAATG 
               
               
                   
               
               
                 AGGCAGATGCTACAGTCGCCGGCGGTAGAGTGCTAAAGAAATCTACTCCCATGAAACCATGCTATGG 
               
               
                   
               
               
                 TTCCTATGCAAGACCCACAAATGCTAATGGAGGTCAGGGTGTACTAACGGCAAATGCCCAGGGACAG 
               
               
                   
               
               
                 CTAGAATCTCAGGTTGAAATGCAATTCTTTTCAACTTCTGAAAACGCCCGTAACGAGGCTAACAACA 
               
               
                   
               
               
                 TTCAGCCCAAATTGGTGCTGTATAGTGAGGATGTGCACATGGAGACCCCGGATACGCACCTTTCTTAC 
               
               
                   
               
               
                 AAGCCCGCAAAAAGCGATGACAATTCAAAAATCATGCTGGGTCAGCAGTCCATGCCCAACAGACCT 
               
               
                   
               
               
                 AATTACATCGGCTTCAGAGACAACTTTATCGGCCTCATGTATTACAATAGCACTGGCAACATGGGAG 
               
               
                   
               
               
                 TGCTTGCAGGTCAGGCCTCTCAGTTGAATGCAGTGGTGGACTTGCAAGACAGAAACACAGAACTGTC 
               
               
                   
               
               
                 CTACCAGCTCTTGCTTGATTCCATGGGTGACAGAACCAGATACTTTTCCATGTGGAATCAGGCAGTGG 
               
               
                   
               
               
                 ACAGTTATGACCCAGATGTTAGAATTATTGAAAATCATGGAACTGAAGACGAGCTCCCCAACTATTG 
               
               
                   
               
               
                 TTTCCCTCTGGGTGGCATAGGGGTAACTGACACTTACCAGGCTGTTAAAACCAACAATGGCAATAAC 
               
               
                   
               
               
                 GGGGGCCAGGTGACTTGGACAAAAGATGAAACTTTTGCAGATCGCAATGAAATAGGGGTGGGAAAC 
               
               
                   
               
               
                 AATTTCGCTATGGAGATCAACCTCAGTGCCAACCTGTGGAGAAACTTCCTGTACTCCAACGTGGCGCT 
               
               
                   
               
               
                 GTACCTACCAGACAAGCTTAAGTACAACCCCTCCAATGTGGACATCTCTGACAACCCCAACACCTAC 
               
               
                   
               
               
                 GATTACATGAACAAGCGAGTGGTGGCCCCGGGGCTGGTGGACTGCTACATCAACCTGGGCGCGCGCT 
               
               
                   
               
               
                 GGTCGCTGGACTACATGGACAACGTCAACCCCTTCAACCACCACCGCAATGCGGGCCTGCGCTACCG 
               
               
                   
               
               
                 CTCCATGCTCCTGGGCAACGGGCGCTACGTGCCCTTCCACATCCAGGTGCCCCAGAAGTTCTTTGCCA 
               
               
                   
               
               
                 TCAAGAACCTCCTCCTCCTGCCGGGCTCCTACACCTACGAGTGGAACTTCAGGAAGGATGTCAACAT 
               
               
                   
               
               
                 GGTCCTCCAGAGCTCTCTGGGTAACGATCTCAGGGTGGACGGGGCCAGCATCAAGTTCGAGAGCATC 
               
               
                   
               
               
                 TGCCTCTACGCCACCTTCTTCCCCATGGCCCACAACACGGCCTCCACGCTCGAGGCCATGCTCAGGAA 
               
               
                   
               
               
                 CGACACCAACGACCAGTCCTTCAATGACTACCTCTCCGCCGCCAACATGCTCTACCCCATACCCGCCA 
               
               
                   
               
               
                 ACGCCACCAACGTCCCCATCTCCATCCCCTCGCGCAACTGGGCGGCCTTCCGCGGCTGGGCCTTCACC 
               
               
                   
               
               
                 CGCCTCAAGACCAAGGAGACCCCCTCCCTGGGCTCGGGATTCGACCCCTACTACACCTACTCGGGCT 
               
               
                   
               
               
                 CCATTCCCTACCTGGACGGCACCTTCTACCTCAACCACACTTTCAAGAAGGTCTCGGTCACCTTCGAC 
               
               
                   
               
               
                 TCCTCGGTCAGCTGGCCGGGCAACGACCGTCTGCTCACCCCCAACGAGTTCGAGATCAAGCGCTCGG 
               
               
                   
               
               
                 TCGACGGGGAGGGCTACAACGTGGCCCAGTGCAACATGACCAAGGACTGGTTCCTGGTCCAGATGCT 
               
               
                   
               
               
                 GGCCAACTACAACATCGGCTACCAGGGCTTCTACATCCCAGAGAGCTACAAGGACAGGATGTACTCC 
               
               
                   
               
               
                 TTCTTCAGGAACTTCCAGCCCATGAGCCGGCAGGTGGTGGACCAGACCAAGTACAAGGACTACCAGG 
               
               
                   
               
               
                 AGGTGGGCATCATCCACCAGCACAACAACTCGGGCTTCGTGGGCTACCTCGCCCCCACCATGCGCGA 
               
               
                   
               
               
                 GGGACAGGCCTACCCCGCCAACTTCCCCTATCCGCTCATAGGCAAGACCGCGGTCGACAGCATCACC 
               
               
                   
               
               
                 CAGAAAAAGTTCCTCTGCGACCGCACCCTCTGGCGCATCCCCTTCTCCAGCAACTTCATGTCCATGGG 
               
               
                   
               
               
                 TGCGCTCTCGGACCTGGGCCAGAACTTGCTCTACGCCAACTCCGCCCACGCCCTCGACATGACCTTCG 
               
               
                   
               
               
                 AGGTCGACCCCATGGACGAGCCCACCCTTCTCTATGTTCTGTTCGAAGTCTTTGACGTGGTCCGGGTC 
               
               
                   
               
               
                 CACCAGCCGCACCGCGGCGTCATCGAGACCGTGTACCTGCGTACGCCCTTCTCGGCCGGCAACGCCA 
               
               
                   
               
               
                 CCACCTAAAGAAGCAAGCCGCAGTCATCGCCGCCTGCATGCCGTCGGGTTCCACCGAGCAAGAGCTC 
               
               
                   
               
               
                 AGGGCCATCGTCAGAGACCTGGGATGCGGGCCCTATTTTTTGGGCACCTTCGACAAGCGCTTCCCTG 
               
               
                   
               
               
                 GCTTTGTCTCCCCACACAAGCTGGCCTGCGCCATCGTCAACACGGCCGGCCGCGAGACCGGGGGCGT 
               
               
                   
               
               
                 GCACTGGCTGGCCTTCGCCTGGAACCCGCGCTCCAAAACATGCTTCCTCTTTGACCCCTTCGGCTTTT 
               
               
                   
               
               
                 CGGACCAGCGGCTCAAGCAAATCTACGAGTTCGAGTACGAGGGCTTGCTGCGTCGCAGCGCCATCGC 
               
               
                   
               
               
                 CTCCTCGCCCGACCGCTGCGTCACCCTCGAAAAGTCCACCCAGACCGTGCAGGGGCCCGACTCGGCC 
               
               
                   
               
               
                 GCCTGCGGTCTCTTCTGCTGCATGTTTCTGCACGCCTTTGTGCACTGGCCTCAGAGTCCCATGGACCG 
               
               
                   
               
               
                 CAACCCCACCATGAACTTGCTGACGGGGGTGCCCAACTCCATGCTCCAGAGCCCCCAGGTCGAGCCC 
               
               
                   
               
               
                 ACCCTGCGCCGCAACCAGGAGCAGCTCTACAGCTTCCTGGAGCGCCACTCGCCTTACTTCCGCCGCC 
               
               
                   
               
               
                 ACAGCGCACAGATCAGGAGGGCCACCTCCTTCTGCCACTTGCAAGAGATGCAAGAAGGGTAATAAC 
               
               
                   
               
               
                 GATGTACACACTTTTTTTCTCAATAAATGGCATCTTTTTATTTATACAAGCTCTCTGGGGTATTCATTT 
               
               
                   
               
               
                 CCCACCACCACCCGCCGTTGTCGCCATCTGGCTCTATTTAGAAATCGAAAGGGTTCTGCCGGGAGTCG 
               
               
                   
               
               
                 CCGTGCGCCACGGGCAGGGACACGTTGCGATACTGGTAGCGGGTGCCCCACTTGAACTCGGGCACCA 
               
               
                   
               
               
                 CCAGGCGAGGCAGCTCGGGGAAGTTTTCGCTCCACAGGCTGCGGGTCAGCACCAGCGCGTTCATCAG 
               
               
                   
               
               
                 GTCGGGCGCCGAGATCTTGAAGTCGCAGTTGGGGCCGCCGCCCTGCGCGCGCGAGTTGCGGTACACC 
               
               
                   
               
               
                 GGGTTGCAGCACTGGAACACCAACAGCGCCGGGTGCTTCACGCTGGCCAGCACGCTGCGGTCGGAG 
               
               
                   
               
               
                 ATCAGCTCGGCGTCCAGGTCCTCCGCGTTGCTCAGCGCGAACGGGGTCATCTTGGGCACTTGCCGCCC 
               
               
                   
               
               
                 CAGGAAGGGCGCGTGCCCCGGTTTCGAGTTGCAGTCGCAGCGCAGCGGGATCAGCAGGTGCCCGTGC 
               
               
                   
               
               
                 CCGGACTCGGCGTTGGGGTACAGCGCGCGCATGAAGGCCTGCATCTGGCGGAAGGCCATCTGGGCCT 
               
               
                   
               
               
                 TGGCGCCCTCCGAGAAGAACATGCCGCAGGACTTGCCCGAGAACTGGTTTGCGGGGCAGCTGGCGTC 
               
               
                   
               
               
                 GTGCAGGCAGCAGCGCGCGTCGGTGTTGGCGATCTGCACCACGTTGCGCCCCCACCGGTTCTTCACG 
               
               
                   
               
               
                 ATCTTGGCCTTGGACGATTGCTCCTTCAGCGCGCGCTGCCCGTTCTCGCTGGTCACATCCATCTCGAT 
               
               
                   
               
               
                 CACATGTTCCTTGTTCACCATGCTGCTGCCGTGCAGACACTTCAGCTCGCCCTCCGTCTCGGTGCAGC 
               
               
                   
               
               
                 GGTGCTGCCACAGCGCGCAGCCCGTGGGCTCGAAAGACTTGTAGGTCACCTCCGCGAAGGACTGCAG 
               
               
                   
               
               
                 GTACCCCTGCAAAAAGCGGCCCATCATGGTCACGAAGGTCTTGTTGCTGCTGAAGGTCAGCTGCAGC 
               
               
                   
               
               
                 CCGCGGTGCTCCTCGTTCAGCCAGGTCTTGCACACGGCCGCCAGCGCCTCCACCTGGTCGGGCAGCA 
               
               
                   
               
               
                 TCTTGAAGTTCACCTTCAGCTCATTCTCCACGTGGTACTTGTCCATCAGCGTGCGCGCCGCCTCCATG 
               
               
                   
               
               
                 CCCTTCTCCCAGGCCGACACCAGCGGCAGGCTCACGGGGTTCTTCACCATCACCGTGGCCGCCGCCTC 
               
               
                   
               
               
                 CGCCGCGCTTTCGCTTTCCGCCCCGCTGTTCTCTTCCTCTTCCTCCTCTTCCTCGCCGCCGCCCACTCGC 
               
               
                   
               
               
                 AGCCCCCGCACCACGGGGTCGTCTTCCTGCAGGCGCTGCACCTTGCGCTTGCCGTTGCGCCCCTGCTT 
               
               
                   
               
               
                 GATGCGCACGGGCGGGTTGCTGAAGCCCACCATCACCAGCGCGGCCTCTTCTTGCTCGTCCTCGCTGT 
               
               
                   
               
               
                 CCAGAATGACCTCCGGGGAGGGGGGGTTGGTCATCCTCAGTACCGAGGCACGCTTCTTTTTCTTCCTG 
               
               
                   
               
               
                 GGGGCGTTCGCCAGCTCCGCGGCTGCGGCCGCTGCCGAGGTCGAAGGCCGAGGGCTGGGCGTGCGC 
               
               
                   
               
               
                 GGCACCAGCGCGTCCTGCGAGCCGTCCTCGTCCTCCTCGGACTCGAGACGGAGGCGGGCCCGCTTCT 
               
               
                   
               
               
                 TCGGGGGCGCGCGGGGCGGCGGAGGCGGCGGCGGCGACGGAGACGGGGACGAGACATCGTCCAGG 
               
               
                   
               
               
                 GTGGGTGGACGGCGGGCCGCGCCGCGTCCGCGCTCGGGGGTGGTCTCGCGCTGGTCCTCTTCCCGAC 
               
               
                   
               
               
                 TGGCCATCTCCCACTGCTCCTTCTCCTATAGGCAGAAAGAGATCATGGAGTCTCTCATGCGAGTCGAG 
               
               
                   
               
               
                 AAGGAGGAGGACAGCCTAACCGCCCCCTCTGAGCCCTCCACCACCGCCGCCACCACCGCCAATGCCG 
               
               
                   
               
               
                 CCGCGGACGACGCGCCCACCGAGACCACCGCCAGTACCACCCTCCCCAGCGACGCACCCCCGCTCGA 
               
               
                   
               
               
                 GAATGAAGTGCTGATCGAGCAGGACCCGGGTTTTGTGAGCGGAGAGGAGGATGAGGTGGATGAGAA 
               
               
                   
               
               
                 GGAGAAGGAGGAGGTCGCCGCCTCAGTGCCAAAAGAGGATAAAAAGCAAGACCAGGACGACGCAG 
               
               
                   
               
               
                 ATAAGGATGAGACAGCAGTCGGGCGGGGGAACGGAAGCCATGATGCTGATGACGGCTACCTAGACG 
               
               
                   
               
               
                 TGGGAGACGACGTGCTGCTTAAGCACCTGCACCGCCAGTGCGTCATCGTCTGCGACGCGCTGCAGGA 
               
               
                   
               
               
                 GCGCTGCGAAGTGCCCCTGGACGTGGCGGAGGTCAGCCGCGCCTACGAGCGGCACCTCTTCGCGCCG 
               
               
                   
               
               
                 CACGTGCCCCCCAAGCGCCGGGAGAACGGCACCTGCGAGCCCAACCCGCGTCTCAACTTCTACCCGG 
               
               
                   
               
               
                 TCTTCGCGGTACCCGAGGTGCTGGCCACCTACCACATCTTTTTCCAAAACTGCAAGATCCCCCTCTCC 
               
               
                   
               
               
                 TGCCGCGCCAACCGCACCCGCGCCGACAAAACCCTGACCCTGCGGCAGGGCGCCCACATACCTGATA 
               
               
                   
               
               
                 TCGCCTCTCTGGAGGAAGTGCCCAAGATCTTCGAGGGTCTCGGTCGCGACGAGAAACGGGCGGCGAA 
               
               
                   
               
               
                 CGCTCTGCACGGAGACAGCGAAAACGAGAGTCACTCGGGGGTGCTGGTGGAGCTCGAGGGCGACAA 
               
               
                   
               
               
                 CGCGCGCCTGGCCGTACTCAAGCGCAGCATAGAGGTCACCCACTTTGCCTACCCGGCGCTCAACCTG 
               
               
                   
               
               
                 CCCCCCAAGGTCATGAGTGTGGTCATGGGCGAGCTCATCATGCGCCGCGCCCAGCCCCTGGCCGCGG 
               
               
                   
               
               
                 ATGCAAACTTGCAAGAGTCCTCCGAGGAAGGCCTGCCCGCGGTCAGCGACGAGCAGCTGGCGCGCT 
               
               
                   
               
               
                 GGCTGGAGACCCGCGACCCCGCGCAGCTGGAGGAGCGGCGCAAGCTCATGATGGCCGCGGTGCTGG 
               
               
                   
               
               
                 TCACCGTGGAGCTCGAGTGTCTGCAGCGCTTCTTCGCGGACCCCGAGATGCAGCGCAAGCTCGAGGA 
               
               
                   
               
               
                 GACCCTGCACTACACCTTCCGCCAGGGCTACGTGCGCCAGGCCTGCAAGATCTCCAACGTGGAGCTC 
               
               
                   
               
               
                 TGCAACCTGGTCTCCTACCTGGGCATCCTGCACGAGAACCGCCTCGGGCAGAACGTCCTGCACTCCA 
               
               
                   
               
               
                 CCCTCAAAGGGGAGGCGCGCCGCGACTACATCCGCGACTGCGCCTACCTCTTCCTCTGCTACACCTG 
               
               
                   
               
               
                 GCAGACGGCCATGGGGGTCTGGCAGCAGTGCCTGGAGGAGCGCAACCTCAAGGAGCTGGAAAAGCT 
               
               
                   
               
               
                 CCTCAAGCGCACCCTCAGGGACCTCTGGACGGGCTTCAACGAGCGCTCGGTGGCCGCCGCGCTGGCG 
               
               
                   
               
               
                 GACATCATCTTTCCCGAGCGCCTGCTCAAGACCCTGCAGCAGGGCCTGCCCGACTTCACCAGCCAGA 
               
               
                   
               
               
                 GCATGCTGCAGAACTTCAGGACTTTCATCCTGGAGCGCTCGGGCATCCTGCCGGCCACTTGCTGCGCG 
               
               
                   
               
               
                 CTGCCCAGCGACTTCGTGCCCATCAAGTACAGGGAGTGCCCGCCGCCGCTCTGGGGCCACTGCTACC 
               
               
                   
               
               
                 TCTTCCAGCTGGCCAACTACCTCGCCTACCACTCGGACCTCATGGAAGACGTGAGCGGCGAGGGCCT 
               
               
                   
               
               
                 GCTCGAGTGCCACTGCCGCTGCAACCTCTGCACGCCCCACCGCTCTCTAGTCTGCAACCCGCAGCTGC 
               
               
                   
               
               
                 TCAGCGAGAGTCAGATTATCGGTACCTTCGAGCTGCAGGGTCCCTCGCCTGACGAGAAGTCCGCGGC 
               
               
                   
               
               
                 TCCAGGGCTGAAACTCACTCCGGGGCTGTGGACTTCCGCCTACCTACGCAAATTTGTACCTGAGGACT 
               
               
                   
               
               
                 ACCACGCCCACGAGATCAGGTTCTACGAAGACCAATCCCGCCCGCCCAAGGCGGAGCTCACCGCCTG 
               
               
                   
               
               
                 CGTCATCACCCAGGGGCACATCCTGGGCCAATTGCAAGCCATCAACAAAGCCCGCCGAGAGTTCTTG 
               
               
                   
               
               
                 CTGAAAAAGGGTCGGGGGGTGTACCTGGACCCCCAGTCCGGCGAGGAGCTAAACCCGCTACCCCCG 
               
               
                   
               
               
                 CCGCCGCCCCAGCAGCGGGACCTTGCTTCCCAGGATGGCACCCAGAAAGAAGCAGCAGCCGCCGCC 
               
               
                   
               
               
                 GCCGCCGCAGCCATACATGCTTCTGGAGGAAGAGGAGGAGGACTGGGACAGTCAGGCAGAGGAGGT 
               
               
                   
               
               
                 TTCGGACGAGGAGCAGGAGGAGATGATGGAAGACTGGGAGGAGGACAGCAGCCTAGACGAGGAAG 
               
               
                   
               
               
                 CTTCAGAGGCCGAAGAGGTGGCAGACGCAACACCATCGCCCTCGGTCGCAGCCCCCTCGCCGGGGCC 
               
               
                   
               
               
                 CCTGAAATCCTCCGAACCCAGCACCAGCGCTATAACCTCCGCTCCTCCGGCGCCGGCGCCACCCGCC 
               
               
                   
               
               
                 CGCAGACCCAACCGTAGATGGGACACCACAGGAACCGGGGTCGGTAAGTCCAAGTGCCCGCCGCCG 
               
               
                   
               
               
                 CCACCGCAGCAGCAGCAGCAGCAGCGCCAGGGCTACCGCTCGTGGCGCGGGCACAAGAACGCCATA 
               
               
                   
               
               
                 GTCGCCTGCTTGCAAGACTGCGGGGGCAACATCTCTTTCGCCCGCCGCTTCCTGCTATTCCACCACGG 
               
               
                   
               
               
                 GGTCGCCTTTCCCCGCAATGTCCTGCATTACTACCGTCATCTCTACAGCCCCTACTGCAGCGGCGACC 
               
               
                   
               
               
                 CAGAGGCGGCAGCGGCAGCCACAGCGGCGACCACCACCTAGGAAGATATCCTCCGCGGGCAAGACA 
               
               
                   
               
               
                 GCGGCAGCAGCGGCCAGGAGACCCGCGGCAGCAGCGGCGGGAGCGGTGGGCGCACTGCGCCTCTCG 
               
               
                   
               
               
                 CCCAACGAACCCCTCTCGACCCGGGAGCTCAGACACAGGATCTTCCCCACTTTGTATGCCATCTTCCA 
               
               
                   
               
               
                 ACAGAGCAGAGGCCAGGAGCAGGAGCTGAAAATAAAAAACAGATCTCTGCGCTCCCTCACCCGCAG 
               
               
                   
               
               
                 CTGTCTGTATCACAAAAGCGAAGATCAGCTTCGGCGCACGCTGGAGGACGCGGAGGCACTCTTCAGC 
               
               
                   
               
               
                 AAATACTGCGCGCTCACTCTTAAAGACTAGCTCCGCGCCCTTCTCGAATTTAGGCGGGAGAAAACTA 
               
               
                   
               
               
                 CGTCATCGCCGGCCGCCGCCCAGCCCGCCCAGCCGAGATGAGCAAAGAGATTCCCACGCCATACATG 
               
               
                   
               
               
                 TGGAGCTACCAGCCGCAGATGGGACTCGCGGCGGGAGCGGCCCAGGACTACTCCACCCGCATGAAC 
               
               
                   
               
               
                 TACATGAGCGCGGGACCCCACATGATCTCACAGGTCAACGGGATCCGCGCCCAGCGAAACCAAATA 
               
               
                   
               
               
                 CTGCTGGAACAGGCGGCCATCACCGCCACGCCCCGCCATAATCTCAACCCCCGAAATTGGCCCGCCG 
               
               
                   
               
               
                 CCCTCGTGTACCAGGAAACCCCCTCCGCCACCACCGTACTACTTCCGCGTGACGCCCAGGCCGAAGT 
               
               
                   
               
               
                 CCAGATGACTAACTCAGGGGCGCAGCTCGCGGGCGGCTTTCGTCACGGGGCGCGGCCGCTCCGACCA 
               
               
                   
               
               
                 GGTATAAGACACCTGATGATCAGAGGCCGAGGTATCCAGCTCAACGACGAGTCGGTGAGCTCTTCGC 
               
               
                   
               
               
                 TCGGTCTCCGTCCGGACGGAACTTTCCAGCTCGCCGGATCCGGCCGCTCTTCGTTCACGCCCCGCCAG 
               
               
                   
               
               
                 GCGTACCTGACTCTGCAGACCTCGTCCTCGGAGCCCCGCTCCGGCGGCATCGGAACCCTCCAGTTCGT 
               
               
                   
               
               
                 GGAGGAGTTCGTGCCCTCGGTCTACTTCAACCCCTTCTCGGGACCTCCCGGACGCTACCCCGACCAGT 
               
               
                   
               
               
                 TCATTCCGAACTTTGACGCGGTGAAGGACTCGGCGGACGGCTACGACTGAATGTCAGGTGTCGAGGC 
               
               
                   
               
               
                 AGAGCAGCTTCGCCTGAGACACCTCGAGCACTGCCGCCGCCACAAGTGCTTCGCCCGCGGTTCTGGT 
               
               
                   
               
               
                 GAGTTCTGCTACTTTCAGCTACCCGAGGAGCATACCGAGGGGCCGGCGCACGGCGTCCGCCTGACCA 
               
               
                   
               
               
                 CCCAGGGCGAGGTTACCTGTTCCCTCATCCGGGAGTTTACCCTCCGTCCCCTGCTAGTGGAGCGGGAG 
               
               
                   
               
               
                 CGGGGTCCCTGTGTCCTAACTATCGCCTGCAACTGCCCTAACCCTGGATTACATCAAGATCTTTGCTG 
               
               
                   
               
               
                 TCATCTCTGTGCTGAGTTTAATAAACGCTGAGATCAGAATCTACTGGGGCTCCTGTCGCCATCCTGTG 
               
               
                   
               
               
                 AACGCCACCGTCTTCACCCACCCCGACCAGGCCCAGGCGAACCTCACCTGCGGTCTGCATCGGAGGG 
               
               
                   
               
               
                 CCAAGAAGTACCTCACCTGGTACTTCAACGGCACCCCCTTTGTGGTTTACAACAGCTTCGACGGGGA 
               
               
                   
               
               
                 CGGAGTCTCCCTGAAAGACCAGCTCTCCGGTCTCAGCTACTCCATCCACAAGAACACCACCCTCCAA 
               
               
                   
               
               
                 CTCTTCCCTCCCTACCTGCCGGGAACCTACGAGTGCGTCACCGGCCGCTGCACCCACCTCACCCGCCT 
               
               
                   
               
               
                 GATCGTAAACCAGAGCTTTCCGGGAACAGATAACTCCCTCTTCCCCAGAACAGGAGGTGAGCTCAGG 
               
               
                   
               
               
                 AAACTCCCCGGGGACCAGGGCGGAGACGTACCTTCGACCCTTGTGGGGTTAGGATTTTTTATTACCG 
               
               
                   
               
               
                 GGTTGCTGGCTCTTTTAATCAAAGTTTCCTTGAGATTTGTTCTTTCCTTCTACGTGTATGAACACCTCA 
               
               
                   
               
               
                 ACCTCCAATAACTCTACCCTTTCTTCGGAATCAGGTGACTTCTCTGAAATCGGGCTTGGTGTGCTGCT 
               
               
                   
               
               
                 TACTCTGTTGATTTTTTTCCTTATCATACTCAGCCTTCTGTGCCTCAGGCTCGCCGCCTGCTGCGCACA 
               
               
                   
               
               
                 CATCTATATCTACTGCTGGTTGCTCAAGTGCAGGGGTCGCCACCCAAGATGAACAGGTACATGGTCC 
               
               
                   
               
               
                 TATCGATCCTAGGCCTGCTGGCCCTGGCGGCCTGCAGCGCCGCCAAAAAAGAGATTACCTTTGAGGA 
               
               
                   
               
               
                 GCCCGCTTGCAATGTAACTTTCAAGCCCGAGGGTGACCAATGCACCACCCTCGTCAAATGCGTTACC 
               
               
                   
               
               
                 AATCATGAGAGGCTGCGCATCGACTACAAAAACAAAACTGGCCAGTTTGCGGTCTATAGTGTGTTTA 
               
               
                   
               
               
                 CGCCCGGAGACCCCTCTAACTACTCTGTCACCGTCTTCCAGGGCGGACAGTCTAAGATATTCAATTAC 
               
               
                   
               
               
                 ACTTTCCCTTTTTATGAGTTATGCGATGCGGTCATGTACATGTCAAAACAGTACAACCTGTGGCCTCC 
               
               
                   
               
               
                 CTCTCCCCAGGCGTGTGTGGAAAATACTGGGTCTTACTGCTGTATGGCTTTCGCAATCACTACGCTCG 
               
               
                   
               
               
                 CTCTAATCTGCACGGTGCTATACATAAAATTCAGGCAGAGGCGAATCTTTATCGATGAAAAGAAAAT 
               
               
                   
               
               
                 GCCTTGATCGCTAACACCGGCTTTCTATCTGCAGAATGAATGCAATCACCTCCCTACTAATCACCACC 
               
               
                   
               
               
                 ACCCTCCTTGCGATTGCCCATGGGTTGACACGAATCGAAGTGCCAGTGGGGTCCAATGTCACCATGG 
               
               
                   
               
               
                 TGGGCCCCGCCGGCAATTCCACCCTCATGTGGGAAAAATTTGTCCGCAATCAATGGGTTCATTTCTGC 
               
               
                   
               
               
                 TCTAACCGAATCAGTATCAAGCCCAGAGCCATCTGCGATGGGCAAAATCTAACTCTGATCAATGTGC 
               
               
                   
               
               
                 AAATGATGGATGCTGGGTACTATTACGGGCAGCGGGGAGAAATCATTAATTACTGGCGACCCCACAA 
               
               
                   
               
               
                 GGACTACATGCTGCATGTAGTCGAGGCACTTCCCACTACCACCCCCACTACCACCTCTCCCACCACCA 
               
               
                   
               
               
                 CCACCACTACTACTACTACTACTACTACTACTACTACTACCACTACCGCTGCCCGCCATACCCGCAAA 
               
               
                   
               
               
                 AGCACCATGATTAGCACAAAGCCCCCTCGTGCTCACTCCCACGCCGGCGGGCCCATCGGTGCGACCT 
               
               
                   
               
               
                 CAGAAACCACCGAGCTTTGCTTCTGCCAATGCACTAACGCCAGCGCTCATGAACTGTTCGACCTGGA 
               
               
                   
               
               
                 GAATGAGGATGTCCAGCAGAGCTCCGCTTGCCTGACCCAGGAGGCTGTGGAGCCCGTTGCCCTGAAG 
               
               
                   
               
               
                 CAGATCGGTGATTCAATAATTGACTCTTCTTCTTTTGCCACTCCCGAATACCCTCCCGATTCTACTTTC 
               
               
                   
               
               
                 CACATCACGGGTACCAAAGACCCTAACCTCTCTTTCTACCTGATGCTGCTGCTCTGTATCTCTGTGGT 
               
               
                   
               
               
                 CTCTTCCGCGCTGATGTTACTGGGGATGTTCTGCTGCCTGATCTGCCGCAGAAAGAGAAAAGCTCGCT 
               
               
                   
               
               
                 CTCAGGGCCAACCACTGATGCCCTTCCCCTACCCCCCGGATTTTGCAGATAACAAGATATGAGCTCGC 
               
               
                   
               
               
                 TGCTGACACTAACCGCTTTACTAGCCTGCGCTCTAACCCTTGTCGCTTGCGACTCGAGATTCCACAAT 
               
               
                   
               
               
                 GTCACAGCTGTGGCAGGAGAAAATGTTACTTTCAACTCCACGGCCGATACCCAGTGGTCGTGGAGTG 
               
               
                   
               
               
                 GCTCAGGTAGCTACTTAACTATCTGCAATAGCTCCACTTCCCCCGGCATATCCCCAACCAAGTACCAA 
               
               
                   
               
               
                 TGCAATGCCAGCCTGTTCACCCTCATCAACGCTTCCACCCTGGACAATGGACTCTATGTAGGCTATGT 
               
               
                   
               
               
                 ACCCTTTGGTGGGCAAGGAAAGACCCACGCTTACAACCTGGAAGTTCGCCAGCCCAGAACCACTACC 
               
               
                   
               
               
                 CAAGCTTCTCCCACCACCACCACCACCACCACCATCACCAGCAGCAGCAGCAGCAGCAGCCACAGCA 
               
               
                   
               
               
                 GCAGCAGCAGATTATTGACTTTGGTTTTGGCCAGCTCATCTGCCGCTACCCAGGCCATCTACAGCTCT 
               
               
                   
               
               
                 GTGCCCGAAACCACTCAGATCCACCGCCCAGAAACGACCACCGCCACCACCCTACACACCTCCAGCG 
               
               
                   
               
               
                 ATCAGATGCCGACCAACATCACCCCCTTGGCTCTTCAAATGGGACTTACAAGCCCCACTCCAAAACC 
               
               
                   
               
               
                 AGTGGATGCGGCCGAGGTCTCCGCCCTCGTCAATGACTGGGCGGGGCTGGGAATGTGGTGGTTCGCC 
               
               
                   
               
               
                 ATAGGCATGATGGCGCTCTGCCTGCTTCTGCTCTGGCTCATCTGCTGCCTCCACCGCAGGCGAGCCAG 
               
               
                   
               
               
                 ACCCCCCATCTATAGACCCATCATTGTCCTGAACCCCGATAATGATGGGATCCATAGATTGGATGGCC 
               
               
                   
               
               
                 TGAAAAACCTACTTTTTTCTTTTACAGTATGATAAATTGAGACATGCCTCGCATTTTCTTGTACATGTT 
               
               
                   
               
               
                 CCTTCTCCCACCTTTTCTGGGGTGTTCTACGCTGGCCGCTGTGTCTCACCTGGAGGTAGACTGCCTCTC 
               
               
                   
               
               
                 ACCCTTCACTGTCTACCTGCTTTACGGATTGGTCACCCTCACTCTCATCTGCAGCCTAATCACAGTAAT 
               
               
                   
               
               
                 CATCGCCTTCATCCAGTGCATTGATTACATCTGTGTGCGCCTCGCATACTTCAGACACCACCCGCAGT 
               
               
                   
               
               
                 ACCGAGACAGGAACATTGCCCAACTTCTAAGACTGCTCTAATCATGCATAAGACTGTGATCTGCCTTC 
               
               
                   
               
               
                 TGATCCTCTGCATCCTGCCCACCCTCACCTCCTGCCAGTACACCACAAAATCTCCGCGCAAAAGACAT 
               
               
                   
               
               
                 GCCTCCTGCCGCTTCACCCAACTGTGGAATATACCCAAATGCTACAACGAAAAGAGCGAGCTCTCCG 
               
               
                   
               
               
                 AAGCTTGGCTGTATGGGGTCATCTGTGTCTTAGTTTTCTGCAGCACTGTCTTTGCCCTCATAATCTACC 
               
               
                   
               
               
                 CCTACTTTGATTTGGGATGGAACGCGATCGATGCCATGAATTACCCCACCTTTCCCGCACCCGAGATA 
               
               
                   
               
               
                 ATTCCACTGCGACAAGTTGTACCCGTTGTCGTTAATCAACGCCCCCCATCCCCTACGCCCACTGAAAT 
               
               
                   
               
               
                 CAGCTACTTTAACCTAACAGGCGGAGATGACTGACGCCCTAGATCTAGAAATGGACGGCATCAGTAC 
               
               
                   
               
               
                 CGAGCAGCGTCTCCTAGAGAGGCGCAGGCAGGCGGCTGAGCAAGAGCGCCTCAATCAGGAGCTCCG 
               
               
                   
               
               
                 AGATCTCGTTAACCTGCACCAGTGCAAAAGAGGCATCTTTTGTCTGGTAAAGCAGGCCAAAGTCACC 
               
               
                   
               
               
                 TACGAGAAGACCGGCAACAGCCACCGCCTCAGTTACAAATTGCCCACCCAGCGCCAGAAGCTGGTGC 
               
               
                   
               
               
                 TCATGGTGGGTGAGAATCCCATCACCGTCACCCAGCACTCGGTAGAGACCGAGGGGTGTCTGCACTC 
               
               
                   
               
               
                 CCCCTGTCGGGGTCCAGAAGACCTCTGCACCCTGGTAAAGACCCTGTGCGGTCTCAGAGATTTAGTC 
               
               
                   
               
               
                 CCCTTTAACTAATCAAACACTGGAATCAATAAAAAGAATCACTTACTTAAAATCAGACAGCAGGTCT 
               
               
                   
               
               
                 CTGTCCAGTTTATTCAGCAGCACCTCCTTCCCCTCCTCCCAACTCTGGTACTCCAAACGCCTTCTGGCG 
               
               
                   
               
               
                 GCAAACTTCCTCCACACCCTGAAGGGAATGTCAGATTCTTGCTCCTGTCCCTCCGCACCCACTATCTT 
               
               
                   
               
               
                 CATGTTGTTGCAGATGAAGCGCACCAAAACGTCTGACGAGAGCTTCAACCCCGTGTACCCCTATGAC 
               
               
                   
               
               
                 ACGGAAAGCGGCCCTCCCTCCGTCCCTTTCCTCACCCCTCCCTTCGTGTCTCCCGATGGATTCCAAGA 
               
               
                   
               
               
                 AAGTCCCCCCGGGGTCCTGTCTCTGAACCTGGCCGAGCCCCTGGTCACTTCCCACGGCATGCTCGCCC 
               
               
                   
               
               
                 TGAAAATGGGAAGTGGCCTCTCCCTGGACGACGCTGGCAACCTCACCTCTCAAGATATCACCACCGC 
               
               
                   
               
               
                 TAGCCCTCCCCTCAAAAAAACCAAGACCAACCTCAGCCTAGAAACCTCATCCCCCCTAACTGTGAGC 
               
               
                   
               
               
                 ACCTCAGGCGCCCTCACCGTAGCAGCCGCCGCTCCCCTGGCGGTGGCCGGCACCTCCCTCACCATGC 
               
               
                   
               
               
                 AATCAGAGGCCCCCCTGACAGTACAGGATGCAAAACTCACCCTGGCCACCAAAGGCCCCCTGACCGT 
               
               
                   
               
               
                 GTCTGAAGGCAAACTGGCCTTGCAAACATCGGCCCCGCTGACGGCCGCTGACAGCAGCACCCTCACA 
               
               
                   
               
               
                 GTCAGTGCCACACCACCCCTTAGCACAAGCAATGGCAGCTTGGGTATTGACATGCAAGCCCCCATTT 
               
               
                   
               
               
                 ACACCACCAATGGAAAACTAGGACTTAACTTTGGCGCTCCCCTGCATGTGGTAGACAGCCTAAATGC 
               
               
                   
               
               
                 ACTGACTGTAGTTACTGGCCAAGGTCTTACGATAAACGGAACAGCCCTACAAACTAGAGTCTCAGGT 
               
               
                   
               
               
                 GCCCTCAACTATGACACATCAGGAAACCTAGAATTGAGAGCTGCAGGGGGTATGCGAGTTGATGCAA 
               
               
                   
               
               
                 ATGGTCAACTTATCCTTGATGTAGCTTACCCATTTGATGCACAAAACAATCTCAGCCTTAGGCTTGGA 
               
               
                   
               
               
                 CAGGGACCCCTGTTTGTTAACTCTGCCCACAACTTGGATGTTAACTACAACAGAGGCCTCTACCTGTT 
               
               
                   
               
               
                 CACATCTGGAAATACCAAAAAGCTAGAAGTTAATATCAAAACAGCCAAGGGTCTCATTTATGATGAC 
               
               
                   
               
               
                 ACTGCTATAGCAATCAATGCGGGTGATGGGCTACAGTTTGACTCAGGCTCAGATACAAATCCATTAA 
               
               
                   
               
               
                 AAACTAAACTTGGATTAGGACTGGATTATGACTCCAGCAGAGCCATAATTGCTAAACTGGGAACTGG 
               
               
                   
               
               
                 CCTAAGCTTTGACAACACAGGTGCCATCACAGTAGGCAACAAAAATGATGACAAGCTTACCTTGTGG 
               
               
                   
               
               
                 ACCACACCAGACCCATCCCCTAACTGTAGAATCTATTCAGAGAAAGATGCTAAATTCACACTTGTTTT 
               
               
                   
               
               
                 GACTAAATGCGGCAGTCAGGTGTTGGCCAGCGTTTCTGTTTTATCTGTAAAAGGTAGCCTTGCGCCCA 
               
               
                   
               
               
                 TCAGTGGCACAGTAACTAGTGCTCAGATTGTCCTCAGATTTGATGAAAATGGAGTTCTACTAAGCAA 
               
               
                   
               
               
                 TTCTTCCCTTGACCCTCAATACTGGAACTACAGAAAAGGTGACCTTACAGAGGGCACTGCATATACC 
               
               
                   
               
               
                 AACGCAGTGGGATTTATGCCCAACCTCACAGCATACCCAAAAACACAGAGCCAAACTGCTAAAAGC 
               
               
                   
               
               
                 AACATTGTAAGTCAGGTTTACTTGAATGGGGACAAATCCAAACCCATGACCCTCACCATTACCCTCA 
               
               
                   
               
               
                 ATGGAACTAATGAAACAGGAGATGCCACAGTAAGCACTTACTCCATGTCATTCTCATGGAACTGGAA 
               
               
                   
               
               
                 TGGAAGTAATTACATTAATGAAACGTTCCAAACCAACTCCTTCACCTTCTCCTACATCGCCCAAGAAT 
               
               
                   
               
               
                 AAAAAGCATGACGCTGTTGATTTGATTCAATGTGTTTCTGTTTTATTTTCAAGCACAACAAAATCATT 
               
               
                   
               
               
                 CAAGTCATTCTTCCATCTTAGCTTAATAGACACAGTAGCTTAATAGACCCAGTAGTGCAAAGCCCCAT 
               
               
                   
               
               
                 TCTAGCTTATAGATCAGACAGTGATAATTAACCACCACCACCACCATACCTTTTGATTCAGGAAATCA 
               
               
                   
               
               
                 TGATCATCACAGGATCCTAGTCTTCAGGCCGCCCCCTCCCTCCCAAGACACAGAATACACAGTCCTCT 
               
               
                   
               
               
                 CCCCCCGACTGGCTTTAAATAACACCATCTGGTTGGTCACAGACATGTTCTTAGGGGTTATATTCCAC 
               
               
                   
               
               
                 ACGGTCTCCTGCCGCGCCAGGCGCTCGTCGGTGATGTTGATAAACTCTCCCGGCAGCTCGCTCAAGTT 
               
               
                   
               
               
                 CACGTCGCTGTCCAGCGGCTGAACCTCCGGCTGACGCGATAACTGTGCGACCGGCTGCTGGACGAAC 
               
               
                   
               
               
                 GGAGGCCGCGCCTACAAGGGGGTAGAGTCATAATCCTCGGTCAGGATAGGGCGGTGATGCAGCAGC 
               
               
                   
               
               
                 AGCGAGCGAAACATCTGCTGCCGCCGCCGCTCCGTCCGGCAGGAAAACAACACGCCGGTGGTCTCCT 
               
               
                   
               
               
                 CCGCGATAATCCGCACCGCCCGCAGCATCAGCTTCCTCGTTCTCCGCGCGCAGCACCTCACCCTTATC 
               
               
                   
               
               
                 TCGCTCAAATCGGCGCAGTAGGTACAGCACAGCACCACGATGTTATTCATGATCCCACAGTGCAGGG 
               
               
                   
               
               
                 CGCTGTATCCAAAGCTCATGCCGGGAACCACCGCCCCCACGTGGCCATCGTACCACAAGCGCACGTA 
               
               
                   
               
               
                 AATCAAGTGTCGACCCCTCATGAACGCGCTGGACACAAACATTACTTCCTTGGGCATGTTGTAATTCA 
               
               
                   
               
               
                 CCACCTCCCGGTACCAGATAAACCTCTGGTTGAACAGGGCACCTTCCACCACCATCCTGAACCAAGA 
               
               
                   
               
               
                 GGCCAGAACCTGCCCACCGGCTATGCACTGCAGGGAACCCGGGTTGGAACAATGACAATGCAGACT 
               
               
                   
               
               
                 CCAAGGCTCGTAACCGTGGATCATCCGGCTGCTGAAGGCATCGATGTTGGCACAACACAGACACACG 
               
               
                   
               
               
                 TGCATGCACTTTCTCATGATTAGCAGCTCTTCCCTCGTCAGGATCATATCCCAAGGAATAACCCATTC 
               
               
                   
               
               
                 TTGAATCAACGTAAAACCCACACAGCAGGGAAGGCCTCGCACATAACTCACGTTGTGCATGGTCAGC 
               
               
                   
               
               
                 GTGTTGCATTCCGGAAACAGCGGATGATCCTCCAGTATCGAGGCGCGGGTCTCCTTCTCACAGGGAG 
               
               
                   
               
               
                 GTAAAGGGTCCCTGCTGTACGGACTGCGCCGGGACGACCGAGATCGTGTTGAGCGTAGTGTCATGGA 
               
               
                   
               
               
                 AAAGGGAACGCCGGACGTGGTCATACTTCTTGAAGCAGAACCAGGTTCGCGCGTGGCAGGCCTCCTT 
               
               
                   
               
               
                 GCGTCTGCGGTCTCGCCGTCTAGCTCGCTCCGTGTGATAGTTGTAGTACAGCCACTCCCGCAGAGCGT 
               
               
                   
               
               
                 CGAGGCGCACCCTGGCTTCCGGATCTATGTAGACTCCGTCTTGCACCGCGGCCCTGATAATATCCACC 
               
               
                   
               
               
                 ACCGTAGAATAAGCAACACCCAGCCAAGCAATACACTCGCTCTGCGAGCGGCAGACAGGAGGAGCG 
               
               
                   
               
               
                 GGCAGAGATGGGAGAACCATGATAAAAAACTTTTTTTAAAGAATATTTTCCAATTCTTCGAAAGTAA 
               
               
                   
               
               
                 GATCTATCAAGTGGCAGCGCTCCCCTCCACTGGCGCGGTCAAACTCTACGGCCAAAGCACAGACAAC 
               
               
                   
               
               
                 GGCATTTCTAAGATGTTCCTTAATGGCGTCCAAAAGACACACCGCTCTCAAGTTGCAGTAAACTATG 
               
               
                   
               
               
                 AATGAAAACCCATCCGGCTGATTTTCCAATATAGACGCGCCGGCAGCGTCCACCAAACCCAGATAAT 
               
               
                   
               
               
                 TTTCTTCTCTCCAGCGGTTTACGATCTGTCTAAGCAAATCCCTTATATCAAGTCCGACCATGCCAAAA 
               
               
                   
               
               
                 ATCTGCTCAAGAGCGCCCTCCACCTTCATGTACAAGCAGCGCATCATGATTGCAAAAATTCAGGTTCT 
               
               
                   
               
               
                 TCAGAGACCTGTATAAGATTCAAAATGGGAACATTAACAAAAATTCCTCTGTCGCGCAGATCCCTTC 
               
               
                   
               
               
                 GCAGGGCAAGCTGAACATAATCAGACAGGTCCGAACGGACCAGTGAGGCCAAATCCCCACCAGGAA 
               
               
                   
               
               
                 CCAGATCCAGAGACCCTATACTGATTATGACGCGCATACTCGGGGCTATGCTGACCAGCGTAGCGCC 
               
               
                   
               
               
                 GATGTAGGCGTGCTGCATGGGCGGCGAGATAAAATGCAAAGTGCTGGTTAAAAAATCAGGCAAAGC 
               
               
                   
               
               
                 CTCGCGCAAAAAAGCTAACACATCATAATCATGCTCATGCAGGTAGTTGCAGGTAAGCTCAGGAACC 
               
               
                   
               
               
                 AAAACGGAATAACACACGATTTTCCTCTCAAACATGACTTCGCGGATACTGCGTAAAACAAAAAATT 
               
               
                   
               
               
                 ATAAATAAAAAATTAATTAAATAACTTAAACATTGGAAGCCTGTCTCACAACAGGAAAAACCACTTT 
               
               
                   
               
               
                 AATCAACATAAGACGGGCCACGGGCATGCCGGCATAGCCGTAAAAAAATTGGTCCCCGTGATTAAC 
               
               
                   
               
               
                 AAGTACCACAGACAGCTCCCCGGTCATGTCGGGGGTCATCATGTGAGACTCTGTATACACGTCTGGA 
               
               
                   
               
               
                 TTGTGAACATCAGACAAACAAAGAAATCGAGCCACGTAGCCCGGAGGTATAATCACCCGCAGGCGG 
               
               
                   
               
               
                 AGGTACAGCAAAACGACCCCCATAGGAGGAATCACAAAATTAGTAGGAGAAAAAAATACATAAACA 
               
               
                   
               
               
                 CCAGAAAAACCCTGTTGCTGAGGCAAAATAGCGCCCTCCCGATCCAAAACAACATAAAGCGCTTCCA 
               
               
                   
               
               
                 CAGGAGCAGCCATAACAAAGACCCGAGTCTTACCAGTAAAAGAAAAAAGATCTCTCAACGCAGCAC 
               
               
                   
               
               
                 CAGCACCAACACTTCGCAGTGTAAAAGGCCAAGTGCCGAGAGAGTATATATAGGAATAAAAAGTGA 
               
               
                   
               
               
                 CGTAAACGGGCAAAGTCCAAAAAACGCCCAGAAAAACCGCACGCGAACCTACGCCCCGAAACGAAA 
               
               
                   
               
               
                 GCCAAAAAACACTAGACACTCCCTTCCGGCGTCAACTTCCGCTTTCCCACGCTACGTCACTTCCCCCG 
               
               
                   
               
               
                 GTCAAACAAACTACATATCCCGAACTTCCAAGTCGCCACGCCCAAAACACCGCCTACACCTCCCCGC 
               
               
                   
               
               
                 CCGCCGGCCCGCCCCCGGACCCGCCTCCCGCCCCGCGCCGCCCATCTCATTATCATATTGGCTTCAAT 
               
               
                   
               
               
                 CCAAAATAAGGTATATTATTGATGATG 
               
               
                   
               
               
                 Polynucleotide sequence encoding ChAd155/RSV 
               
               
                 SEQ ID NO: 11 
                   
               
               
                 CATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGATGGGCGGCGCGGGGCG 
                   
               
               
                   
               
               
                 GGGCGCGGGGCGGGAGGCGGGTTTGGGGGCGGGCCGGCGGGCGGGGCGGTGTGGCGGAAGTGGAC 
               
               
                   
               
               
                 TTTGTAAGTGTGGCGGATGTGACTTGCTAGTGCCGGGCGCGGTAAAAGTGACGTTTTCCGTGCGCGA 
               
               
                   
               
               
                 CAACGCCCCCGGGAAGTGACATTTTTCCCGCGGTTTTTACCGGATGTTGTAGTGAATTTGGGCGTAAC 
               
               
                   
               
               
                 CAAGTAAGATTTGGCCATTTTCGCGGGAAAACTGAAACGGGGAAGTGAAATCTGATTAATTTTGCGT 
               
               
                   
               
               
                 TAGTCATACCGCGTAATATTTGTCTAGGGCCGAGGGACTTTGGCCGATTACGTGGAGGACTCGCCCA 
               
               
                   
               
               
                 GGTGTTTTTTGAGGTGAATTTCCGCGTTCCGGGTCAAAGTCTGCGTTTTATTATTATAGGATATCCCAT 
               
               
                   
               
               
                 TGCATACGTTGTATCCATATCATAATATGTACATTTATATTGGCTCATGTCCAACATTACCGCCATGTT 
               
               
                   
               
               
                 GACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATG 
               
               
                   
               
               
                 GAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCAT 
               
               
                   
               
               
                 TGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGT 
               
               
                   
               
               
                 GGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCT 
               
               
                   
               
               
                 ATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCC 
               
               
                   
               
               
                 TACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCA 
               
               
                   
               
               
                 ATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAG 
               
               
                   
               
               
                 TTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAA 
               
               
                   
               
               
                 TGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCCCTATCAGTGATAGAGATCT 
               
               
                   
               
               
                 CCCTATCAGTGATAGAGATCGTCGACGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCAT 
               
               
                   
               
               
                 CCACGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCAGCCTCCGCGGCCGGGAACGGTGCA 
               
               
                   
               
               
                 TTGGAACGCGGATTCCCCGTGCCAAGAGTGAGATCTTCCGTTTATCTAGGTACCAGATATCGCCACCA 
               
               
                   
               
               
                 TGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGCTTCGCC 
               
               
                   
               
               
                 AGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGAGCAAGGGCTACCTG 
               
               
                   
               
               
                 AGCGCCCTGAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAAC 
               
               
                   
               
               
                 AAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAGGAACTGGACAAGTACAAGAACGCC 
               
               
                   
               
               
                 GTGACCGAGCTGCAGCTGCTGATGCAGAGCACCCCCGCCACCAACAACCGGGCCAGACGGGAGCTG 
               
               
                   
               
               
                 CCCCGGTTCATGAACTACACCCTGAACAACGCCAAAAAGACCAACGTGACCCTGAGCAAGAAGCGG 
               
               
                   
               
               
                 AAGCGGCGGTTCCTGGGCTTTCTGCTGGGCGTGGGCAGCGCCATTGCCAGCGGCGTGGCCGTGTCTA 
               
               
                   
               
               
                 AGGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCG 
               
               
                   
               
               
                 TGGTGTCCCTGAGCAACGGCGTGAGCGTGCTGACCAGCAAGGTGCTGGATCTGAAGAACTACATCGA 
               
               
                   
               
               
                 CAAGCAGCTGCTGCCCATCGTGAACAAGCAGAGCTGCAGCATCAGCAACATCGAGACAGTGATCGA 
               
               
                   
               
               
                 GTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGGGAGTTCAGCGTGAACGCCGGCGTGAC 
               
               
                   
               
               
                 CACCCCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATC 
               
               
                   
               
               
                 ACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACTCCATC 
               
               
                   
               
               
                 ATGTCCATCATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCCCTGTACGGCGTGATCGACA 
               
               
                   
               
               
                 CCCCCTGCTGGAAGCTGCACACCAGCCCCCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTG 
               
               
                   
               
               
                 CCTGACCCGGACCGACAGAGGCTGGTACTGCGACAACGCCGGCAGCGTGTCATTCTTTCCACAGGCC 
               
               
                   
               
               
                 GAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAACAGCCTGACCCTGCCCTCCG 
               
               
                   
               
               
                 AAGTGAACCTGTGCAACGTGGACATCTTCAACCCCAAGTACGACTGCAAGATCATGACCTCCAAGAC 
               
               
                   
               
               
                 CGACGTGTCCAGCTCCGTGATCACCTCCCTGGGCGCCATCGTGTCCTGCTACGGCAAGACCAAGTGC 
               
               
                   
               
               
                 ACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAAC 
               
               
                   
               
               
                 AAGGGGGTGGACACCGTGTCCGTGGGCAACACCCTGTACTACGTGAACAAACAGGAAGGCAAGAGC 
               
               
                   
               
               
                 CTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCCCTGGTGTTCCCCAGCGACGAGTTCG 
               
               
                   
               
               
                 ACGCCAGCATCAGCCAGGTGAACGAGAAGATCAACCAGAGCCTGGCCTTCATCCGGAAGTCCGACG 
               
               
                   
               
               
                 AGCTGCTGCACAATGTGAATGCCGGCAAGTCCACCACCAACCGGAAGCGGAGAGCCCCTGTGAAGC 
               
               
                   
               
               
                 AGACCCTGAACTTCGACCTGCTGAAGCTGGCCGGCGACGTGGAGAGCAATCCCGGCCCTATGGCCCT 
               
               
                   
               
               
                 GAGCAAAGTGAAACTGAACGATACACTGAACAAGGACCAGCTGCTGTCCAGCAGCAAGTACACCAT 
               
               
                   
               
               
                 CCAGCGGAGCACCGGCGACAGCATCGATACCCCCAACTACGACGTGCAGAAGCACATCAACAAGCT 
               
               
                   
               
               
                 GTGCGGCATGCTGCTGATCACAGAGGACGCCAACCACAAGTTCACCGGCCTGATCGGCATGCTGTAC 
               
               
                   
               
               
                 GCCATGAGCCGGCTGGGCCGGGAGGACACCATCAAGATCCTGCGGGACGCCGGCTACCACGTGAAG 
               
               
                   
               
               
                 GCCAATGGCGTGGACGTGACCACACACCGGCAGGACATCAACGGCAAAGAAATGAAGTTCGAGGTG 
               
               
                   
               
               
                 CTGACCCTGGCCAGCCTGACCACCGAGATCCAGATCAATATCGAGATCGAGAGCCGGAAGTCCTACA 
               
               
                   
               
               
                 AGAAAATGCTGAAAGAAATGGGCGAGGTGGCCCCCGAGTACAGACACGACAGCCCCGACTGCGGCA 
               
               
                   
               
               
                 TGATCATCCTGTGTATCGCCGCCCTGGTGATCACAAAGCTGGCCGCTGGCGACAGATCTGGCCTGAC 
               
               
                   
               
               
                 AGCCGTGATCAGACGGGCCAACAATGTGCTGAAGAACGAGATGAAGCGGTACAAGGGCCTGCTGCC 
               
               
                   
               
               
                 CAAGGACATTGCCAACAGCTTCTACGAGGTGTTCGAGAAGTACCCCCACTTCATCGACGTGTTCGTG 
               
               
                   
               
               
                 CACTTCGGCATTGCCCAGAGCAGCACCAGAGGCGGCTCCAGAGTGGAGGGCATCTTCGCCGGCCTGT 
               
               
                   
               
               
                 TCATGAACGCCTACGGCGCTGGCCAGGTGATGCTGAGATGGGGCGTGCTGGCCAAGAGCGTGAAGA 
               
               
                   
               
               
                 ACATCATGCTGGGCCACGCCAGCGTGCAGGCCGAGATGGAACAGGTGGTGGAGGTGTACGAGTACG 
               
               
                   
               
               
                 CCCAGAAGCTGGGCGGAGAGGCCGGCTTCTACCACATCCTGAACAACCCTAAGGCCTCCCTGCTGTC 
               
               
                   
               
               
                 CCTGACCCAGTTCCCCCACTTCTCCAGCGTGGTGCTGGGAAATGCCGCCGGACTGGGCATCATGGGC 
               
               
                   
               
               
                 GAGTACCGGGGCACCCCCAGAAACCAGGACCTGTACGACGCCGCCAAGGCCTACGCCGAGCAGCTG 
               
               
                   
               
               
                 AAAGAAAACGGCGTGATCAACTACAGCGTGCTGGACCTGACCGCTGAGGAACTGGAAGCCATCAAG 
               
               
                   
               
               
                 CACCAGCTGAACCCCAAGGACAACGACGTGGAGCTGGGAGGCGGAGGATCTGGCGGCGGAGGCATG 
               
               
                   
               
               
                 AGCAGACGGAACCCCTGCAAGTTCGAGATCCGGGGCCACTGCCTGAACGGCAAGCGGTGCCACTTCA 
               
               
                   
               
               
                 GCCACAACTACTTCGAGTGGCCCCCTCATGCTCTGCTGGTGCGGCAGAACTTCATGCTGAACCGGATC 
               
               
                   
               
               
                 CTGAAGTCCATGGACAAGAGCATCGACACCCTGAGCGAGATCAGCGGAGCCGCCGAGCTGGACAGA 
               
               
                   
               
               
                 ACCGAGGAATATGCCCTGGGCGTGGTGGGAGTGCTGGAAAGCTACATCGGCTCCATCAACAACATCA 
               
               
                   
               
               
                 CAAAGCAGAGCGCCTGCGTGGCCATGAGCAAGCTGCTGACAGAGCTGAACAGCGACGACATCAAGA 
               
               
                   
               
               
                 AGCTGAGGGACAACGAGGAACTGAACAGCCCCAAGATCCGGGTGTACAACACCGTGATCAGCTACA 
               
               
                   
               
               
                 TTGAGAGCAACCGCAAGAACAACAAGCAGACCATCCATCTGCTGAAGCGGCTGCCCGCCGACGTGCT 
               
               
                   
               
               
                 GAAAAAGACCATCAAGAACACCCTGGACATCCACAAGTCCATCACCATCAACAATCCCAAAGAAAG 
               
               
                   
               
               
                 CACCGTGTCTGACACCAACGATCACGCCAAGAACAACGACACCACCTGATGAGCGGCCGCGATCTGC 
               
               
                   
               
               
                 TGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGC 
               
               
                   
               
               
                 CACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTA 
               
               
                   
               
               
                 TTCTGGGGGGTGGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTG 
               
               
                   
               
               
                 GGGATGCGGTGGGCTCTATGGCCGATCAGCGATCGCTGAGGTGGGTGAGTGGGCGTGGCCTGGGGTG 
               
               
                   
               
               
                 GTCATGAAAATATATAAGTTGGGGGTCTTAGGGTCTCTTTATTTGTGTTGCAGAGACCGCCGGAGCCA 
               
               
                   
               
               
                 TGAGCGGGAGCAGCAGCAGCAGCAGTAGCAGCAGCGCCTTGGATGGCAGCATCGTGAGCCCTTATTT 
               
               
                   
               
               
                 GACGACGCGGATGCCCCACTGGGCCGGGGTGCGTCAGAATGTGATGGGCTCCAGCATCGACGGCCG 
               
               
                   
               
               
                 ACCCGTCCTGCCCGCAAATTCCGCCACGCTGACCTATGCGACCGTCGCGGGGACGCCGTTGGACGCC 
               
               
                   
               
               
                 ACCGCCGCCGCCGCCGCCACCGCAGCCGCCTCGGCCGTGCGCAGCCTGGCCACGGACTTTGCATTCC 
               
               
                   
               
               
                 TGGGACCACTGGCGACAGGGGCTACTTCTCGGGCCGCTGCTGCCGCCGTTCGCGATGACAAGCTGAC 
               
               
                   
               
               
                 CGCCCTGCTGGCGCAGTTGGATGCGCTTACTCGGGAACTGGGTGACCTTTCTCAGCAGGTCATGGCCC 
               
               
                   
               
               
                 TGCGCCAGCAGGTCTCCTCCCTGCAAGCTGGCGGGAATGCTTCTCCCACAAATGCCGTTTAAGATAA 
               
               
                   
               
               
                 ATAAAACCAGACTCTGTTTGGATTAAAGAAAAGTAGCAAGTGCATTGCTCTCTTTATTTCATAATTTT 
               
               
                   
               
               
                 CCGCGCGCGATAGGCCCTAGACCAGCGTTCTCGGTCGTTGAGGGTGCGGTGTATCTTCTCCAGGACG 
               
               
                   
               
               
                 TGGTAGAGGTGGCTCTGGACGTTGAGATACATGGGCATGAGCCCGTCCCGGGGGTGGAGGTAGCACC 
               
               
                   
               
               
                 ACTGCAGAGCTTCATGCTCCGGGGTGGTGTTGTAGATGATCCAGTCGTAGCAGGAGCGCTGGGCATG 
               
               
                   
               
               
                 GTGCCTAAAAATGTCCTTCAGCAGCAGGCCGATGGCCAGGGGGAGGCCCTTGGTGTAAGTGTTTACA 
               
               
                   
               
               
                 AAACGGTTAAGTTGGGAAGGGTGCATTCGGGGAGAGATGATGTGCATCTTGGACTGTATTTTTAGAT 
               
               
                   
               
               
                 TGGCGATGTTTCCGCCCAGATCCCTTCTGGGATTCATGTTGTGCAGGACCACCAGTACAGTGTATCCG 
               
               
                   
               
               
                 GTGCACTTGGGGAATTTGTCATGCAGCTTAGAGGGAAAAGCGTGGAAGAACTTGGAGACGCCTTTGT 
               
               
                   
               
               
                 GGCCTCCCAGATTTTCCATGCATTCGTCCATGATGATGGCAATGGGCCCGCGGGAGGCAGCTTGGGC 
               
               
                   
               
               
                 AAAGATATTTCTGGGGTCGCTGACGTCGTAGTTGTGTTCCAGGGTGAGGTCGTCATAGGCCATTTTTA 
               
               
                   
               
               
                 CAAAGCGCGGGCGGAGGGTGCCCGACTGGGGGATGATGGTCCCCTCTGGCCCTGGGGCGTAGTTGCC 
               
               
                   
               
               
                 CTCGCAGATCTGCATTTCCCAGGCCTTAATCTCGGAGGGGGGAATCATATCCACCTGCGGGGCGATG 
               
               
                   
               
               
                 AAGAAAACGGTTTCCGGAGCCGGGGAGATTAACTGGGATGAGAGCAGGTTTCTAAGCAGCTGTGATT 
               
               
                   
               
               
                 TTCCACAACCGGTGGGCCCATAAATAACACCTATAACCGGTTGCAGCTGGTAGTTTAGAGAGCTGCA 
               
               
                   
               
               
                 GCTGCCGTCGTCCCGGAGGAGGGGGGCCACCTCGTTGAGCATGTCCCTGACGCGCATGTTCTCCCCG 
               
               
                   
               
               
                 ACCAGATCCGCCAGAAGGCGCTCGCCGCCCAGGGACAGCAGCTCTTGCAAGGAAGCAAAGTTTTTCA 
               
               
                   
               
               
                 GCGGCTTGAGGCCGTCCGCCGTGGGCATGTTTTTCAGGGTCTGGCTCAGCAGCTCCAGGCGGTCCCA 
               
               
                   
               
               
                 GAGCTCGGTGACGTGCTCTACGGCATCTCTATCCAGCATATCTCCTCGTTTCGCGGGTTGGGGCGACT 
               
               
                   
               
               
                 TTCGCTGTAGGGCACCAAGCGGTGGTCGTCCAGCGGGGCCAGAGTCATGTCCTTCCATGGGCGCAGG 
               
               
                   
               
               
                 GTCCTCGTCAGGGTGGTCTGGGTCACGGTGAAGGGGTGCGCTCCGGGCTGAGCGCTTGCCAAGGTGC 
               
               
                   
               
               
                 GCTTGAGGCTGGTTCTGCTGGTGCTGAAGCGCTGCCGGTCTTCGCCCTGCGCGTCGGCCAGGTAGCAT 
               
               
                   
               
               
                 TTGACCATGGTGTCATAGTCCAGCCCCTCCGCGGCGTGTCCCTTGGCGCGCAGCTTGCCCTTGGAGGT 
               
               
                   
               
               
                 GGCGCCGCACGAGGGGCAGAGCAGGCTCTTGAGCGCGTAGAGCTTGGGGGCGAGGAAGACCGATTC 
               
               
                   
               
               
                 GGGGGAGTAGGCGTCCGCGCCGCAGACCCCGCACACGGTCTCGCACTCCACCAGCCAGGTGAGCTCG 
               
               
                   
               
               
                 GGGCGCGCCGGGTCAAAAACCAGGTTTCCCCCATGCTTTTTGATGCGTTTCTTACCTCGGGTCTCCAT 
               
               
                   
               
               
                 GAGGTGGTGTCCCCGCTCGGTGACGAAGAGGCTGTCCGTGTCTCCGTAGACCGACTTGAGGGGTCTT 
               
               
                   
               
               
                 TTCTCCAGGGGGGTCCCTCGGTCTTCCTCGTAGAGGAACTCGGACCACTCTGAGACGAAGGCCCGCG 
               
               
                   
               
               
                 TCCAGGCCAGGACGAAGGAGGCTATGTGGGAGGGGTAGCGGTCGTTGTCCACTAGGGGGTCCACCTT 
               
               
                   
               
               
                 CTCCAAGGTGTGAAGACACATGTCGCCTTCCTCGGCGTCCAGGAAGGTGATTGGCTTGTAGGTGTAG 
               
               
                   
               
               
                 GCCACGTGACCGGGGGTTCCTGACGGGGGGGTATAAAAGGGGGTGGGGGCGCGCTCGTCGTCACTCT 
               
               
                   
               
               
                 CTTCCGCATCGCTGTCTGCGAGGGCCAGCTGCTGGGGTGAGTATTCCCTCTCGAAGGCGGGCATGAC 
               
               
                   
               
               
                 CTCCGCGCTGAGGTTGTCAGTTTCCAAAAACGAGGAGGATTTGATGTTCACCTGTCCCGAGGTGATA 
               
               
                   
               
               
                 CCTTTGAGGGTACCCGCGTCCATCTGGTCAGAAAACACGATCTTTTTATTGTCCAGCTTGGTGGCGAA 
               
               
                   
               
               
                 CGACCCGTAGAGGGCGTTGGAGAGCAGCTTGGCGATGGAGCGCAGGGTCTGGTTCTTGTCCCTGTCG 
               
               
                   
               
               
                 GCGCGCTCCTTGGCCGCGATGTTGAGCTGCACGTACTCGCGCGCGACGCAGCGCCACTCGGGGAAGA 
               
               
                   
               
               
                 CGGTGGTGCGCTCGTCGGGCACCAGGCGCACGCGCCAGCCGCGGTTGTGCAGGGTGACCAGGTCCAC 
               
               
                   
               
               
                 GCTGGTGGCGACCTCGCCGCGCAGGCGCTCGTTGGTCCAGCAGAGACGGCCGCCCTTGCGCGAGCAG 
               
               
                   
               
               
                 AAGGGGGGCAGGGGGTCGAGCTGGGTCTCGTCCGGGGGGTCCGCGTCCACGGTGAAAACCCCGGGG 
               
               
                   
               
               
                 CGCAGGCGCGCGTCGAAGTAGTCTATCTTGCAACCTTGCATGTCCAGCGCCTGCTGCCAGTCGCGGG 
               
               
                   
               
               
                 CGGCGAGCGCGCGCTCGTAGGGGTTGAGCGGCGGGCCCCAGGGCATGGGGTGGGTGAGTGCGGAGG 
               
               
                   
               
               
                 CGTACATGCCGCAGATGTCATAGACGTAGAGGGGCTCCCGCAGGACCCCGATGTAGGTGGGGTAGC 
               
               
                   
               
               
                 AGCGGCCGCCGCGGATGCTGGCGCGCACGTAGTCATACAGCTCGTGCGAGGGGGCGAGGAGGTCGG 
               
               
                   
               
               
                 GGCCCAGGTTGGTGCGGGCGGGGCGCTCCGCGCGGAAGACGATCTGCCTGAAGATGGCATGCGAGT 
               
               
                   
               
               
                 TGGAAGAGATGGTGGGGCGCTGGAAGACGTTGAAGCTGGCGTCCTGCAGGCCGACGGCGTCGCGCA 
               
               
                   
               
               
                 CGAAGGAGGCGTAGGAGTCGCGCAGCTTGTGTACCAGCTCGGCGGTGACCTGCACGTCGAGCGCGC 
               
               
                   
               
               
                 AGTAGTCGAGGGTCTCGCGGATGATGTCATATTTAGCCTGCCCCTTCTTTTTCCACAGCTCGCGGTTG 
               
               
                   
               
               
                 AGGACAAACTCTTCGCGGTCTTTCCAGTACTCTTGGATCGGGAAACCGTCCGGTTCCGAACGGTAAG 
               
               
                   
               
               
                 AGCCTAGCATGTAGAACTGGTTGACGGCCTGGTAGGCGCAGCAGCCCTTCTCCACGGGGAGGGCGTA 
               
               
                   
               
               
                 GGCCTGCGCGGCCTTGCGGAGCGAGGTGTGGGTCAGGGCGAAGGTGTCCCTGACCATGACTTTGAGG 
               
               
                   
               
               
                 TACTGGTGCTTGAAGTCGGAGTCGTCGCAGCCGCCCCGCTCCCAGAGCGAGAAGTCGGTGCGCTTCT 
               
               
                   
               
               
                 TGGAGCGGGGGTTGGGCAGAGCGAAGGTGACATCGTTGAAGAGGATTTTGCCCGCGCGGGGCATGA 
               
               
                   
               
               
                 AGTTGCGGGTGATGCGGAAGGGCCCCGGCACTTCAGAGCGGTTGTTGATGACCTGGGCGGCGAGCAC 
               
               
                   
               
               
                 GATCTCGTCGAAGCCGTTGATGTTGTGGCCCACGATGTAGAGTTCCAGGAAGCGGGGCCGGCCCTTT 
               
               
                   
               
               
                 ACGGTGGGCAGCTTCTTTAGCTCTTCGTAGGTGAGCTCCTCGGGCGAGGCGAGGCCGTGCTCGGCCA 
               
               
                   
               
               
                 GGGCCCAGTCCGCGAGGTGCGGGTTGTCTCTGAGGAAGGACTTCCAGAGGTCGCGGGCCAGGAGGG 
               
               
                   
               
               
                 TCTGCAGGCGGTCTCTGAAGGTCCTGAACTGGCGGCCCACGGCCATTTTTTCGGGGGTGATGCAGTA 
               
               
                   
               
               
                 GAAGGTGAGGGGGTCTTGCTGCCAGCGGTCCCAGTCGAGCTGCAGGGCGAGGTCGCGCGCGGCGGT 
               
               
                   
               
               
                 GACCAGGCGCTCGTCGCCCCCGAATTTCATGACCAGCATGAAGGGCACGAGCTGCTTTCCGAAGGCC 
               
               
                   
               
               
                 CCCATCCAAGTGTAGGTCTCTACATCGTAGGTGACAAAGAGGCGCTCCGTGCGAGGATGCGAGCCGA 
               
               
                   
               
               
                 TCGGGAAGAACTGGATCTCCCGCCACCAGTTGGAGGAGTGGCTGTTGATGTGGTGGAAGTAGAAGTC 
               
               
                   
               
               
                 CCGTCGCCGGGCCGAACACTCGTGCTGGCTTTTGTAAAAGCGAGCGCAGTACTGGCAGCGCTGCACG 
               
               
                   
               
               
                 GGCTGTACCTCATGCACGAGATGCACCTTTCGCCCGCGCACGAGGAAGCCGAGGGGAAATCTGAGCC 
               
               
                   
               
               
                 CCCCGCCTGGCTCGCGGCATGGCTGGTTCTCTTCTACTTTGGATGCGTGTCCGTCTCCGTCTGGCTCCT 
               
               
                   
               
               
                 CGAGGGGTGTTACGGTGGAGCGGACCACCACGCCGCGCGAGCCGCAGGTCCAGATATCGGCGCGCG 
               
               
                   
               
               
                 GCGGTCGGAGTTTGATGACGACATCGCGCAGCTGGGAGCTGTCCATGGTCTGGAGCTCCCGCGGCGG 
               
               
                   
               
               
                 CGGCAGGTCAGCCGGGAGTTCTTGCAGGTTCACCTCGCAGAGTCGGGCCAGGGCGCGGGGCAGGTCT 
               
               
                   
               
               
                 AGGTGGTACCTGATCTCTAGGGGCGTGTTGGTGGCGGCGTCGATGGCTTGCAGGAGCCCGCAGCCCC 
               
               
                   
               
               
                 GGGGGGCGACGACGGTGCCCCGCGGGGTGGTGGTGGTGGTGGCGGTGCAGCTCAGAAGCGGTGCCG 
               
               
                   
               
               
                 CGGGCGGGCCCCCGGAGGTAGGGGGGGCTCCGGTCCCGCGGGCAGGGGCGGCAGCGGCACGTCGGC 
               
               
                   
               
               
                 GTGGAGCGCGGGCAGGAGTTGGTGCTGTGCCCGGAGGTTGCTGGCGAAGGCGACGACGCGGCGGTT 
               
               
                   
               
               
                 GATCTCCTGGATCTGGCGCCTCTGCGTGAAGACGACGGGCCCGGTGAGCTTGAACCTGAAAGAGAGT 
               
               
                   
               
               
                 TCGACAGAATCAATCTCGGTGTCATTGACCGCGGCCTGGCGCAGGATCTCCTGCACGTCTCCCGAGTT 
               
               
                   
               
               
                 GTCTTGGTAGGCGATCTCGGCCATGAACTGCTCGATCTCTTCCTCCTGGAGGTCTCCGCGTCCGGCGC 
               
               
                   
               
               
                 GTTCCACGGTGGCCGCCAGGTCGTTGGAGATGCGCCCCATGAGCTGCGAGAAGGCGTTGAGTCCGCC 
               
               
                   
               
               
                 CTCGTTCCAGACTCGGCTGTAGACCACGCCCCCCTGGTCATCGCGGGCGCGCATGACCACCTGCGCG 
               
               
                   
               
               
                 AGGTTGAGCTCCACGTGCCGCGCGAAGACGGCGTAGTTGCGCAGACGCTGGAAGAGGTAGTTGAGG 
               
               
                   
               
               
                 GTGGTGGCGGTGTGCTCGGCCACGAAGAAGTTCATGACCCAGCGGCGCAACGTGGATTCGTTGATGT 
               
               
                   
               
               
                 CCCCCAAGGCCTCCAGCCGTTCCATGGCCTCGTAGAAGTCCACGGCGAAGTTGAAAAACTGGGAGTT 
               
               
                   
               
               
                 GCGCGCCGACACGGTCAACTCCTCCTCCAGAAGACGGATGAGCTCGGCGACGGTGTCGCGCACCTCG 
               
               
                   
               
               
                 CGCTCGAAGGCTATGGGGATCTCTTCCTCCGCTAGCATCACCACCTCCTCCTCTTCCTCCTCTTCTGGC 
               
               
                   
               
               
                 ACTTCCATGATGGCTTCCTCCTCTTCGGGGGGTGGCGGCGGCGGCGGTGGGGGAGGGGGCGCTCTGC 
               
               
                   
               
               
                 GCCGGCGGCGGCGCACCGGGAGGCGGTCCACGAAGCGCGCGATCATCTCCCCGCGGCGGCGGCGCA 
               
               
                   
               
               
                 TGGTCTCGGTGACGGCGCGGCCGTTCTCCCGGGGGCGCAGTTGGAAGACGCCGCCGGACATCTGGTG 
               
               
                   
               
               
                 CTGGGGCGGGTGGCCGTGAGGCAGCGAGACGGCGCTGACGATGCATCTCAACAATTGCTGCGTAGGT 
               
               
                   
               
               
                 ACGCCGCCGAGGGACCTGAGGGAGTCCATATCCACCGGATCCGAAAACCTTTCGAGGAAGGCGTCTA 
               
               
                   
               
               
                 ACCAGTCGCAGTCGCAAGGTAGGCTGAGCACCGTGGCGGGCGGCGGGGGGTGGGGGGAGTGTCTGG 
               
               
                   
               
               
                 CGGAGGTGCTGCTGATGATGTAATTGAAGTAGGCGGACTTGACACGGCGGATGGTCGACAGGAGCA 
               
               
                   
               
               
                 CCATGTCCTTGGGTCCGGCCTGCTGGATGCGGAGGCGGTCGGCTATGCCCCAGGCTTCGTTCTGGCAT 
               
               
                   
               
               
                 CGGCGCAGGTCCTTGTAGTAGTCTTGCATGAGCCTTTCCACCGGCACCTCTTCTCCTTCCTCTTCTGCT 
               
               
                   
               
               
                 TCTTCCATGTCTGCTTCGGCCCTGGGGCGGCGCCGCGCCCCCCTGCCCCCCATGCGCGTGACCCCGAA 
               
               
                   
               
               
                 CCCCCTGAGCGGTTGGAGCAGGGCCAGGTCGGCGACGACGCGCTCGGCCAGGATGGCCTGCTGCACC 
               
               
                   
               
               
                 TGCGTGAGGGTGGTTTGGAAGTCATCCAAGTCCACGAAGCGGTGGTAGGCGCCCGTGTTGATGGTGT 
               
               
                   
               
               
                 AGGTGCAGTTGGCCATGACGGACCAGTTGACGGTCTGGTGGCCCGGTTGCGACATCTCGGTGTACCT 
               
               
                   
               
               
                 GAGTCGCGAGTAGGCGCGGGAGTCGAAGACGTAGTCGTTGCAAGTCCGCACCAGGTACTGGTAGCC 
               
               
                   
               
               
                 CACCAGGAAGTGCGGCGGCGGCTGGCGGTAGAGGGGCCAGCGCAGGGTGGCGGGGGCTCCGGGGGC 
               
               
                   
               
               
                 CAGGTCTTCCAGCATGAGGCGGTGGTAGGCGTAGATGTACCTGGACATCCAGGTGATACCCGCGGCG 
               
               
                   
               
               
                 GTGGTGGAGGCGCGCGGGAAGTCGCGCACCCGGTTCCAGATGTTGCGCAGGGGCAGAAAGTGCTCC 
               
               
                   
               
               
                 ATGGTAGGCGTGCTCTGTCCAGTCAGACGCGCGCAGTCGTTGATACTCTAGACCAGGGAAAACGAAA 
               
               
                   
               
               
                 GCCGGTCAGCGGGCACTCTTCCGTGGTCTGGTGAATAGATCGCAAGGGTATCATGGCGGAGGGCCTC 
               
               
                   
               
               
                 GGTTCGAGCCCCGGGTCCGGGCCGGACGGTCCGCCATGATCCACGCGGTTACCGCCCGCGTGTCGAA 
               
               
                   
               
               
                 CCCAGGTGTGCGACGTCAGACAACGGTGGAGTGTTCCTTTTGGCGTTTTTCTGGCCGGGCGCCGGCGC 
               
               
                   
               
               
                 CGCGTAAGAGACTAAGCCGCGAAAGCGAAAGCAGTAAGTGGCTCGCTCCCCGTAGCCGGAGGGATC 
               
               
                   
               
               
                 CTTGCTAAGGGTTGCGTTGCGGCGAACCCCGGTTCGAATCCCGTACTCGGGCCGGCCGGACCCGCGG 
               
               
                   
               
               
                 CTAAGGTGTTGGATTGGCCTCCCCCTCGTATAAAGACCCCGCTTGCGGATTGACTCCGGACACGGGG 
               
               
                   
               
               
                 ACGAGCCCCTTTTATTTTTGCTTTCCCCAGATGCATCCGGTGCTGCGGCAGATGCGCCCCCCGCCCCA 
               
               
                   
               
               
                 GCAGCAGCAACAACACCAGCAAGAGCGGCAGCAACAGCAGCGGGAGTCATGCAGGGCCCCCTCACC 
               
               
                   
               
               
                 CACCCTCGGCGGGCCGGCCACCTCGGCGTCCGCGGCCGTGTCTGGCGCCTGCGGCGGCGGCGGGGGG 
               
               
                   
               
               
                 CCGGCTGACGACCCCGAGGAGCCCCCGCGGCGCAGGGCCAGACACTACCTGGACCTGGAGGAGGGC 
               
               
                   
               
               
                 GAGGGCCTGGCGCGGCTGGGGGCGCCGTCTCCCGAGCGCCACCCGCGGGTGCAGCTGAAGCGCGAC 
               
               
                   
               
               
                 TCGCGCGAGGCGTACGTGCCTCGGCAGAACCTGTTCAGGGACCGCGCGGGCGAGGAGCCCGAGGAG 
               
               
                   
               
               
                 ATGCGGGACAGGAGGTTCAGCGCAGGGCGGGAGCTGCGGCAGGGGCTGAACCGCGAGCGGCTGCTG 
               
               
                   
               
               
                 CGCGAGGAGGACTTTGAGCCCGACGCGCGGACGGGGATCAGCCCCGCGCGCGCGCACGTGGCGGCC 
               
               
                   
               
               
                 GCCGACCTGGTGACGGCGTACGAGCAGACGGTGAACCAGGAGATCAACTTCCAAAAGAGTTTCAAC 
               
               
                   
               
               
                 AACCACGTGCGCACGCTGGTGGCGCGCGAGGAGGTGACCATCGGGCTGATGCACCTGTGGGACTTTG 
               
               
                   
               
               
                 TAAGCGCGCTGGTGCAGAACCCCAACAGCAAGCCTCTGACGGCGCAGCTGTTCCTGATAGTGCAGCA 
               
               
                   
               
               
                 CAGCAGGGACAACGAGGCGTTTAGGGACGCGCTGCTGAACATCACCGAGCCCGAGGGTCGGTGGCT 
               
               
                   
               
               
                 GCTGGACCTGATTAACATCCTGCAGAGCATAGTGGTGCAGGAGCGCAGCCTGAGCCTGGCCGACAAG 
               
               
                   
               
               
                 GTGGCGGCCATCAACTACTCGATGCTGAGCCTGGGCAAGTTTTACGCGCGCAAGATCTACCAGACGC 
               
               
                   
               
               
                 CGTACGTGCCCATAGACAAGGAGGTGAAGATCGACGGTTTTTACATGCGCATGGCGCTGAAGGTGCT 
               
               
                   
               
               
                 CACCCTGAGCGACGACCTGGGCGTGTACCGCAACGAGCGCATCCACAAGGCCGTGAGCGTGAGCCG 
               
               
                   
               
               
                 GCGGCGCGAGCTGAGCGACCGCGAGCTGATGCACAGCCTGCAGCGGGCGCTGGCGGGCGCCGGCAG 
               
               
                   
               
               
                 CGGCGACAGGGAGGCGGAGTCCTACTTCGATGCGGGGGCGGACCTGCGCTGGGCGCCCAGCCGGCG 
               
               
                   
               
               
                 GGCCCTGGAGGCCGCGGGGGTCCGCGAGGACTATGACGAGGACGGCGAGGAGGATGAGGAGTACG 
               
               
                   
               
               
                 AGCTAGAGGAGGGCGAGTACCTGGACTAAACCGCGGGTGGTGTTTCCGGTAGATGCAAGACCCGAA 
               
               
                   
               
               
                 CGTGGTGGACCCGGCGCTGCGGGCGGCTCTGCAGAGCCAGCCGTCCGGCCTTAACTCCTCAGACGAC 
               
               
                   
               
               
                 TGGCGACAGGTCATGGACCGCATCATGTCGCTGACGGCGCGTAACCCGGACGCGTTCCGGCAGCAGC 
               
               
                   
               
               
                 CGCAGGCCAACAGGCTCTCCGCCATCCTGGAGGCGGTGGTGCCTGCGCGCTCGAACCCCACGCACGA 
               
               
                   
               
               
                 GAAGGTGCTGGCCATAGTGAACGCGCTGGCCGAGAACAGGGCCATCCGCCCGGACGAGGCCGGGCT 
               
               
                   
               
               
                 GGTGTACGACGCGCTGCTGCAGCGCGTGGCCCGCTACAACAGCGGCAACGTGCAGACCAACCTGGA 
               
               
                   
               
               
                 CCGGCTGGTGGGGGACGTGCGCGAGGCGGTGGCGCAGCGCGAGCGCGCGGATCGGCAGGGCAACCT 
               
               
                   
               
               
                 GGGCTCCATGGTGGCGCTGAATGCCTTCCTGAGCACGCAGCCGGCCAACGTGCCGCGGGGGCAGGA 
               
               
                   
               
               
                 AGACTACACCAACTTTGTGAGCGCGCTGCGGCTGATGGTGACCGAGACCCCCCAGAGCGAGGTGTAC 
               
               
                   
               
               
                 CAGTCGGGCCCGGACTACTTCTTCCAGACCAGCAGACAGGGCCTGCAGACGGTGAACCTGAGCCAGG 
               
               
                   
               
               
                 CTTTCAAGAACCTGCGGGGGCTGTGGGGCGTGAAGGCGCCCACCGGCGACCGGGCGACGGTGTCCA 
               
               
                   
               
               
                 GCCTGCTGACGCCCAACTCGCGCCTGCTGCTGCTGCTGATCGCGCCGTTCACGGACAGCGGCAGCGT 
               
               
                   
               
               
                 GTCCCGGGACACCTACCTGGGGCACCTGCTGACCCTGTACCGCGAGGCCATCGGGCAGGCGCAGGTG 
               
               
                   
               
               
                 GACGAGCACACCTTCCAGGAGATCACCAGCGTGAGCCGCGCGCTGGGGCAGGAGGACACGAGCAGC 
               
               
                   
               
               
                 CTGGAGGCGACTCTGAACTACCTGCTGACCAACCGGCGGCAGAAGATTCCCTCGCTGCACAGCCTGA 
               
               
                   
               
               
                 CCTCCGAGGAGGAGCGCATCTTGCGCTACGTGCAGCAGAGCGTGAGCCTGAACCTGATGCGCGACGG 
               
               
                   
               
               
                 GGTGACGCCCAGCGTGGCGCTGGACATGACCGCGCGCAACATGGAACCGGGCATGTACGCCGCGCA 
               
               
                   
               
               
                 CCGGCCTTACATCAACCGCCTGATGGACTACCTGCATCGCGCGGCGGCCGTGAACCCCGAGTACTTT 
               
               
                   
               
               
                 ACCAACGCCATCCTGAACCCGCACTGGCTCCCGCCGCCCGGGTTCTACAGCGGGGGCTTCGAGGTCC 
               
               
                   
               
               
                 CGGAGACCAACGATGGCTTCCTGTGGGACGACATGGACGACAGCGTGTTCTCCCCGCGGCCGCAGGC 
               
               
                   
               
               
                 GCTGGCGGAAGCGTCCCTGCTGCGTCCCAAGAAGGAGGAGGAGGAGGAGGCGAGTCGCCGCCGCGG 
               
               
                   
               
               
                 CAGCAGCGGCGTGGCTTCTCTGTCCGAGCTGGGGGCGGCAGCCGCCGCGCGCCCCGGGTCCCTGGGC 
               
               
                   
               
               
                 GGCAGCCCCTTTCCGAGCCTGGTGGGGTCTCTGCACAGCGAGCGCACCACCCGCCCTCGGCTGCTGG 
               
               
                   
               
               
                 GCGAGGACGAGTACCTGAATAACTCCCTGCTGCAGCCGGTGCGGGAGAAAAACCTGCCTCCCGCCTT 
               
               
                   
               
               
                 CCCCAACAACGGGATAGAGAGCCTGGTGGACAAGATGAGCAGATGGAAGACCTATGCGCAGGAGCA 
               
               
                   
               
               
                 CAGGGACGCGCCTGCGCTCCGGCCGCCCACGCGGCGCCAGCGCCACGACCGGCAGCGGGGGCTGGT 
               
               
                   
               
               
                 GTGGGATGACGAGGACTCCGCGGACGATAGCAGCGTGCTGGACCTGGGAGGGAGCGGCAACCCGTT 
               
               
                   
               
               
                 CGCGCACCTGCGCCCCCGCCTGGGGAGGATGTTTTAAAAAAAAAAAAAAAAAGCAAGAAGCATGAT 
               
               
                   
               
               
                 GCAAAAATTAAATAAAACTCACCAAGGCCATGGCGACCGAGCGTTGGTTTCTTGTGTTCCCTTCAGT 
               
               
                   
               
               
                 ATGCGGCGCGCGGCGATGTACCAGGAGGGACCTCCTCCCTCTTACGAGAGCGTGGTGGGCGCGGCGG 
               
               
                   
               
               
                 CGGCGGCGCCCTCTTCTCCCTTTGCGTCGCAGCTGCTGGAGCCGCCGTACGTGCCTCCGCGCTACCTG 
               
               
                   
               
               
                 CGGCCTACGGGGGGGAGAAACAGCATCCGTTACTCGGAGCTGGCGCCCCTGTTCGACACCACCCGGG 
               
               
                   
               
               
                 TGTACCTGGTGGACAACAAGTCGGCGGACGTGGCCTCCCTGAACTACCAGAACGACCACAGCAATTT 
               
               
                   
               
               
                 TTTGACCACGGTCATCCAGAACAATGACTACAGCCCGAGCGAGGCCAGCACCCAGACCATCAATCTG 
               
               
                   
               
               
                 GATGACCGGTCGCACTGGGGCGGCGACCTGAAAACCATCCTGCACACCAACATGCCCAACGTGAAC 
               
               
                   
               
               
                 GAGTTCATGTTCACCAATAAGTTCAAGGCGCGGGTGATGGTGTCGCGCTCGCACACCAAGGAAGACC 
               
               
                   
               
               
                 GGGTGGAGCTGAAGTACGAGTGGGTGGAGTTCGAGCTGCCAGAGGGCAACTACTCCGAGACCATGA 
               
               
                   
               
               
                 CCATTGACCTGATGAACAACGCGATCGTGGAGCACTATCTGAAAGTGGGCAGGCAGAACGGGGTCCT 
               
               
                   
               
               
                 GGAGAGCGACATCGGGGTCAAGTTCGACACCAGGAACTTCCGCCTGGGGCTGGACCCCGTGACCGG 
               
               
                   
               
               
                 GCTGGTTATGCCCGGGGTGTACACCAACGAGGCCTTCCATCCCGACATCATCCTGCTGCCCGGCTGCG 
               
               
                   
               
               
                 GGGTGGACTTCACTTACAGCCGCCTGAGCAACCTCCTGGGCATCCGCAAGCGGCAGCCCTTCCAGGA 
               
               
                   
               
               
                 GGGCTTCAGGATCACCTACGAGGACCTGGAGGGGGGCAACATCCCCGCGCTCCTCGATGTGGAGGCC 
               
               
                   
               
               
                 TACCAGGATAGCTTGAAGGAAAATGAGGCGGGACAGGAGGATACCGCCCCCGCCGCCTCCGCCGCC 
               
               
                   
               
               
                 GCCGAGCAGGGCGAGGATGCTGCTGACACCGCGGCCGCGGACGGGGCAGAGGCCGACCCCGCTATG 
               
               
                   
               
               
                 GTGGTGGAGGCTCCCGAGCAGGAGGAGGACATGAATGACAGTGCGGTGCGCGGAGACACCTTCGTC 
               
               
                   
               
               
                 ACCCGGGGGGAGGAAAAGCAAGCGGAGGCCGAGGCCGCGGCCGAGGAAAAGCAACTGGCGGCAGC 
               
               
                   
               
               
                 AGCGGCGGCGGCGGCGTTGGCCGCGGCGGAGGCTGAGTCTGAGGGGACCAAGCCCGCCAAGGAGCC 
               
               
                   
               
               
                 CGTGATTAAGCCCCTGACCGAAGATAGCAAGAAGCGCAGTTACAACCTGCTCAAGGACAGCACCAA 
               
               
                   
               
               
                 CACCGCGTACCGCAGCTGGTACCTGGCCTACAACTACGGCGACCCGTCGACGGGGGTGCGCTCCTGG 
               
               
                   
               
               
                 ACCCTGCTGTGCACGCCGGACGTGACCTGCGGCTCGGAGCAGGTGTACTGGTCGCTGCCCGACATGA 
               
               
                   
               
               
                 TGCAAGACCCCGTGACCTTCCGCTCCACGCGGCAGGTCAGCAACTTCCCGGTGGTGGGCGCCGAGCT 
               
               
                   
               
               
                 GCTGCCCGTGCACTCCAAGAGCTTCTACAACGACCAGGCCGTCTACTCCCAGCTCATCCGCCAGTTCA 
               
               
                   
               
               
                 CCTCTCTGACCCACGTGTTCAATCGCTTTCCTGAGAACCAGATTCTGGCGCGCCCGCCCGCCCCCACC 
               
               
                   
               
               
                 ATCACCACCGTCAGTGAAAACGTTCCTGCTCTCACAGATCACGGGACGCTACCGCTGCGCAACAGCA 
               
               
                   
               
               
                 TCGGAGGAGTCCAGCGAGTGACCGTTACTGACGCCAGACGCCGCACCTGCCCCTACGTTTACAAGGC 
               
               
                   
               
               
                 CTTGGGCATAGTCTCGCCGCGCGTCCTTTCCAGCCGCACTTTTTGAGCAACACCACCATCATGTCCAT 
               
               
                   
               
               
                 CCTGATCTCACCCAGCAATAACTCCGGCTGGGGACTGCTGCGCGCGCCCAGCAAGATGTTCGGAGGG 
               
               
                   
               
               
                 GCGAGGAAGCGTTCCGAGCAGCACCCCGTGCGCGTGCGCGGGCACTTCCGCGCCCCCTGGGGAGCGC 
               
               
                   
               
               
                 ACAAACGCGGCCGCGCGGGGCGCACCACCGTGGACGACGCCATCGACTCGGTGGTGGAGCAGGCGC 
               
               
                   
               
               
                 GCAACTACAGGCCCGCGGTCTCTACCGTGGACGCGGCCATCCAGACCGTGGTGCGGGGCGCGCGGCG 
               
               
                   
               
               
                 GTACGCCAAGCTGAAGAGCCGCCGGAAGCGCGTGGCCCGCCGCCACCGCCGCCGACCCGGGGCCGC 
               
               
                   
               
               
                 CGCCAAACGCGCCGCCGCGGCCCTGCTTCGCCGGGCCAAGCGCACGGGCCGCCGCGCCGCCATGAG 
               
               
                   
               
               
                 GGCCGCGCGCCGCTTGGCCGCCGGCATCACCGCCGCCACCATGGCCCCCCGTACCCGAAGACGCGCG 
               
               
                   
               
               
                 GCCGCCGCCGCCGCCGCCGCCATCAGTGACATGGCCAGCAGGCGCCGGGGCAACGTGTACTGGGTGC 
               
               
                   
               
               
                 GCGACTCGGTGACCGGCACGCGCGTGCCCGTGCGCTTCCGCCCCCCGCGGACTTGAGATGATGTGAA 
               
               
                   
               
               
                 AAAACAACACTGAGTCTCCTGCTGTTGTGTGTATCCCAGCGGCGGCGGCGCGCGCAGCGTCATGTCC 
               
               
                   
               
               
                 AAGCGCAAAATCAAAGAAGAGATGCTCCAGGTCGTCGCGCCGGAGATCTATGGGCCCCCGAAGAAG 
               
               
                   
               
               
                 GAAGAGCAGGATTCGAAGCCCCGCAAGATAAAGCGGGTCAAAAAGAAAAAGAAAGATGATGACGA 
               
               
                   
               
               
                 TGCCGATGGGGAGGTGGAGTTCCTGCGCGCCACGGCGCCCAGGCGCCCGGTGCAGTGGAAGGGCCG 
               
               
                   
               
               
                 GCGCGTAAAGCGCGTCCTGCGCCCCGGCACCGCGGTGGTCTTCACGCCCGGCGAGCGCTCCACCCGG 
               
               
                   
               
               
                 ACTTTCAAGCGCGTCTATGACGAGGTGTACGGCGACGAAGACCTGCTGGAGCAGGCCAACGAGCGCT 
               
               
                   
               
               
                 TCGGAGAGTTTGCTTACGGGAAGCGTCAGCGGGCGCTGGGGAAGGAGGACCTGCTGGCGCTGCCGCT 
               
               
                   
               
               
                 GGACCAGGGCAACCCCACCCCCAGTCTGAAGCCCGTGACCCTGCAGCAGGTGCTGCCGAGCAGCGC 
               
               
                   
               
               
                 ACCCTCCGAGGCGAAGCGGGGTCTGAAGCGCGAGGGCGGCGACCTGGCGCCCACCGTGCAGCTCAT 
               
               
                   
               
               
                 GGTGCCCAAGCGGCAGAGGCTGGAGGATGTGCTGGAGAAAATGAAAGTAGACCCCGGTCTGCAGCC 
               
               
                   
               
               
                 GGACATCAGGGTCCGCCCCATCAAGCAGGTGGCGCCGGGCCTCGGCGTGCAGACCGTGGACGTGGTC 
               
               
                   
               
               
                 ATCCCCACCGGCAACTCCCCCGCCGCCGCCACCACTACCGCTGCCTCCACGGACATGGAGACACAGA 
               
               
                   
               
               
                 CCGATCCCGCCGCAGCCGCAGCCGCAGCCGCCGCCGCGACCTCCTCGGCGGAGGTGCAGACGGACCC 
               
               
                   
               
               
                 CTGGCTGCCGCCGGCGATGTCAGCTCCCCGCGCGCGTCGCGGGCGCAGGAAGTACGGCGCCGCCAAC 
               
               
                   
               
               
                 GCGCTCCTGCCCGAGTACGCCTTGCATCCTTCCATCGCGCCCACCCCCGGCTACCGAGGCTATACCTA 
               
               
                   
               
               
                 CCGCCCGCGAAGAGCCAAGGGTTCCACCCGCCGTCCCCGCCGACGCGCCGCCGCCACCACCCGCCGC 
               
               
                   
               
               
                 CGCCGCCGCAGACGCCAGCCCGCACTGGCTCCAGTCTCCGTGAGGAAAGTGGCGCGCGACGGACAC 
               
               
                   
               
               
                 ACCCTGGTGCTGCCCAGGGCGCGCTACCACCCCAGCATCGTTTAAAAGCCTGTTGTGGTTCTTGCAGA 
               
               
                   
               
               
                 TATGGCCCTCACTTGCCGCCTCCGTTTCCCGGTGCCGGGATACCGAGGAGGAAGATCGCGCCGCAGG 
               
               
                   
               
               
                 AGGGGTCTGGCCGGCCGCGGCCTGAGCGGAGGCAGCCGCCGCGCGCACCGGCGGCGACGCGCCACC 
               
               
                   
               
               
                 AGCCGACGCATGCGCGGCGGGGTGCTGCCCCTGTTAATCCCCCTGATCGCCGCGGCGATCGGCGCCG 
               
               
                   
               
               
                 TGCCCGGGATCGCCTCCGTGGCCTTGCAAGCGTCCCAGAGGCATTGACAGACTTGCAAACTTGCAAA 
               
               
                   
               
               
                 TATGGAAAAAAAAACCCCAATAAAAAAGTCTAGACTCTCACGCTCGCTTGGTCCTGTGACTATTTTGT 
               
               
                   
               
               
                 AGAATGGAAGACATCAACTTTGCGTCGCTGGCCCCGCGTCACGGCTCGCGCCCGTTCCTGGGACACT 
               
               
                   
               
               
                 GGAACGATATCGGCACCAGCAACATGAGCGGTGGCGCCTTCAGTTGGGGCTCTCTGTGGAGCGGCAT 
               
               
                   
               
               
                 TAAAAGTATCGGGTCTGCCGTTAAAAATTACGGCTCCCGGGCCTGGAACAGCAGCACGGGCCAGATG 
               
               
                   
               
               
                 TTGAGAGACAAGTTGAAAGAGCAGAACTTCCAGCAGAAGGTGGTGGAGGGCCTGGCCTCCGGCATC 
               
               
                   
               
               
                 AACGGGGTGGTGGACCTGGCCAACCAGGCCGTGCAGAATAAGATCAACAGCAGACTGGACCCCCGG 
               
               
                   
               
               
                 CCGCCGGTGGAGGAGGTGCCGCCGGCGCTGGAGACGGTGTCCCCCGATGGGCGTGGCGAGAAGCGC 
               
               
                   
               
               
                 CCGCGGCCCGATAGGGAAGAGACCACTCTGGTCACGCAGACCGATGAGCCGCCCCCGTATGAGGAG 
               
               
                   
               
               
                 GCCCTGAAGCAAGGTCTGCCCACCACGCGGCCCATCGCGCCCATGGCCACCGGGGTGGTGGGCCGCC 
               
               
                   
               
               
                 ACACCCCCGCCACGCTGGACTTGCCTCCGCCCGCCGATGTGCCGCAGCAGCAGAAGGCGGCACAGCC 
               
               
                   
               
               
                 GGGCCCGCCCGCGACCGCCTCCCGTTCCTCCGCCGGTCCTCTGCGCCGCGCGGCCAGCGGCCCCCGC 
               
               
                   
               
               
                 GGGGGGGTCGCGAGGCACGGCAACTGGCAGAGCACGCTGAACAGCATCGTGGGTCTGGGGGTGCGG 
               
               
                   
               
               
                 TCCGTGAAGCGCCGCCGATGCTACTGAATAGCTTAGCTAACGTGTTGTATGTGTGTATGCGCCCTATG 
               
               
                   
               
               
                 TCGCCGCCAGAGGAGCTGCTGAGTCGCCGCCGTTCGCGCGCCCACCACCACCGCCACTCCGCCCCTC 
               
               
                   
               
               
                 AAGATGGCGACCCCATCGATGATGCCGCAGTGGTCGTACATGCACATCTCGGGCCAGGACGCCTCGG 
               
               
                   
               
               
                 AGTACCTGAGCCCCGGGCTGGTGCAGTTCGCCCGCGCCACCGAGAGCTACTTCAGCCTGAGTAACAA 
               
               
                   
               
               
                 GTTTAGGAACCCCACGGTGGCGCCCACGCACGATGTGACCACCGACCGGTCTCAGCGCCTGACGCTG 
               
               
                   
               
               
                 CGGTTCATTCCCGTGGACCGCGAGGACACCGCGTACTCGTACAAGGCGCGGTTCACCCTGGCCGTGG 
               
               
                   
               
               
                 GCGACAACCGCGTGCTGGACATGGCCTCCACCTACTTTGACATCCGCGGGGTGCTGGACCGGGGTCC 
               
               
                   
               
               
                 CACTTTCAAGCCCTACTCTGGCACCGCCTACAACTCCCTGGCCCCCAAGGGCGCTCCCAACTCCTGCG 
               
               
                   
               
               
                 AGTGGGAGCAAGAGGAAACTCAGGCAGTTGAAGAAGCAGCAGAAGAGGAAGAAGAAGATGCTGAC 
               
               
                   
               
               
                 GGTCAAGCTGAGGAAGAGCAAGCAGCTACCAAAAAGACTCATGTATATGCTCAGGCTCCCCTTTCTG 
               
               
                   
               
               
                 GCGAAAAAATTAGTAAAGATGGTCTGCAAATAGGAACGGACGCTACAGCTACAGAACAAAAACCTA 
               
               
                   
               
               
                 TTTATGCAGACCCTACATTCCAGCCCGAACCCCAAATCGGGGAGTCCCAGTGGAATGAGGCAGATGC 
               
               
                   
               
               
                 TACAGTCGCCGGCGGTAGAGTGCTAAAGAAATCTACTCCCATGAAACCATGCTATGGTTCCTATGCA 
               
               
                   
               
               
                 AGACCCACAAATGCTAATGGAGGTCAGGGTGTACTAACGGCAAATGCCCAGGGACAGCTAGAATCT 
               
               
                   
               
               
                 CAGGTTGAAATGCAATTCTTTTCAACTTCTGAAAACGCCCGTAACGAGGCTAACAACATTCAGCCCA 
               
               
                   
               
               
                 AATTGGTGCTGTATAGTGAGGATGTGCACATGGAGACCCCGGATACGCACCTTTCTTACAAGCCCGC 
               
               
                   
               
               
                 AAAAAGCGATGACAATTCAAAAATCATGCTGGGTCAGCAGTCCATGCCCAACAGACCTAATTACATC 
               
               
                   
               
               
                 GGCTTCAGAGACAACTTTATCGGCCTCATGTATTACAATAGCACTGGCAACATGGGAGTGCTTGCAG 
               
               
                   
               
               
                 GTCAGGCCTCTCAGTTGAATGCAGTGGTGGACTTGCAAGACAGAAACACAGAACTGTCCTACCAGCT 
               
               
                   
               
               
                 CTTGCTTGATTCCATGGGTGACAGAACCAGATACTTTTCCATGTGGAATCAGGCAGTGGACAGTTATG 
               
               
                   
               
               
                 ACCCAGATGTTAGAATTATTGAAAATCATGGAACTGAAGACGAGCTCCCCAACTATTGTTTCCCTCTG 
               
               
                   
               
               
                 GGTGGCATAGGGGTAACTGACACTTACCAGGCTGTTAAAACCAACAATGGCAATAACGGGGGCCAG 
               
               
                   
               
               
                 GTGACTTGGACAAAAGATGAAACTTTTGCAGATCGCAATGAAATAGGGGTGGGAAACAATTTCGCTA 
               
               
                   
               
               
                 TGGAGATCAACCTCAGTGCCAACCTGTGGAGAAACTTCCTGTACTCCAACGTGGCGCTGTACCTACC 
               
               
                   
               
               
                 AGACAAGCTTAAGTACAACCCCTCCAATGTGGACATCTCTGACAACCCCAACACCTACGATTACATG 
               
               
                   
               
               
                 AACAAGCGAGTGGTGGCCCCGGGGCTGGTGGACTGCTACATCAACCTGGGCGCGCGCTGGTCGCTGG 
               
               
                   
               
               
                 ACTACATGGACAACGTCAACCCCTTCAACCACCACCGCAATGCGGGCCTGCGCTACCGCTCCATGCT 
               
               
                   
               
               
                 CCTGGGCAACGGGCGCTACGTGCCCTTCCACATCCAGGTGCCCCAGAAGTTCTTTGCCATCAAGAAC 
               
               
                   
               
               
                 CTCCTCCTCCTGCCGGGCTCCTACACCTACGAGTGGAACTTCAGGAAGGATGTCAACATGGTCCTCCA 
               
               
                   
               
               
                 GAGCTCTCTGGGTAACGATCTCAGGGTGGACGGGGCCAGCATCAAGTTCGAGAGCATCTGCCTCTAC 
               
               
                   
               
               
                 GCCACCTTCTTCCCCATGGCCCACAACACGGCCTCCACGCTCGAGGCCATGCTCAGGAACGACACCA 
               
               
                   
               
               
                 ACGACCAGTCCTTCAATGACTACCTCTCCGCCGCCAACATGCTCTACCCCATACCCGCCAACGCCACC 
               
               
                   
               
               
                 AACGTCCCCATCTCCATCCCCTCGCGCAACTGGGCGGCCTTCCGCGGCTGGGCCTTCACCCGCCTCAA 
               
               
                   
               
               
                 GACCAAGGAGACCCCCTCCCTGGGCTCGGGATTCGACCCCTACTACACCTACTCGGGCTCCATTCCCT 
               
               
                   
               
               
                 ACCTGGACGGCACCTTCTACCTCAACCACACTTTCAAGAAGGTCTCGGTCACCTTCGACTCCTCGGTC 
               
               
                   
               
               
                 AGCTGGCCGGGCAACGACCGTCTGCTCACCCCCAACGAGTTCGAGATCAAGCGCTCGGTCGACGGGG 
               
               
                   
               
               
                 AGGGCTACAACGTGGCCCAGTGCAACATGACCAAGGACTGGTTCCTGGTCCAGATGCTGGCCAACTA 
               
               
                   
               
               
                 CAACATCGGCTACCAGGGCTTCTACATCCCAGAGAGCTACAAGGACAGGATGTACTCCTTCTTCAGG 
               
               
                   
               
               
                 AACTTCCAGCCCATGAGCCGGCAGGTGGTGGACCAGACCAAGTACAAGGACTACCAGGAGGTGGGC 
               
               
                   
               
               
                 ATCATCCACCAGCACAACAACTCGGGCTTCGTGGGCTACCTCGCCCCCACCATGCGCGAGGGACAGG 
               
               
                   
               
               
                 CCTACCCCGCCAACTTCCCCTATCCGCTCATAGGCAAGACCGCGGTCGACAGCATCACCCAGAAAAA 
               
               
                   
               
               
                 GTTCCTCTGCGACCGCACCCTCTGGCGCATCCCCTTCTCCAGCAACTTCATGTCCATGGGTGCGCTCT 
               
               
                   
               
               
                 CGGACCTGGGCCAGAACTTGCTCTACGCCAACTCCGCCCACGCCCTCGACATGACCTTCGAGGTCGA 
               
               
                   
               
               
                 CCCCATGGACGAGCCCACCCTTCTCTATGTTCTGTTCGAAGTCTTTGACGTGGTCCGGGTCCACCAGC 
               
               
                   
               
               
                 CGCACCGCGGCGTCATCGAGACCGTGTACCTGCGTACGCCCTTCTCGGCCGGCAACGCCACCACCTA 
               
               
                   
               
               
                 AAGAAGCAAGCCGCAGTCATCGCCGCCTGCATGCCGTCGGGTTCCACCGAGCAAGAGCTCAGGGCC 
               
               
                   
               
               
                 ATCGTCAGAGACCTGGGATGCGGGCCCTATTTTTTGGGCACCTTCGACAAGCGCTTCCCTGGCTTTGT 
               
               
                   
               
               
                 CTCCCCACACAAGCTGGCCTGCGCCATCGTCAACACGGCCGGCCGCGAGACCGGGGGCGTGCACTGG 
               
               
                   
               
               
                 CTGGCCTTCGCCTGGAACCCGCGCTCCAAAACATGCTTCCTCTTTGACCCCTTCGGCTTTTCGGACCA 
               
               
                   
               
               
                 GCGGCTCAAGCAAATCTACGAGTTCGAGTACGAGGGCTTGCTGCGTCGCAGCGCCATCGCCTCCTCG 
               
               
                   
               
               
                 CCCGACCGCTGCGTCACCCTCGAAAAGTCCACCCAGACCGTGCAGGGGCCCGACTCGGCCGCCTGCG 
               
               
                   
               
               
                 GTCTCTTCTGCTGCATGTTTCTGCACGCCTTTGTGCACTGGCCTCAGAGTCCCATGGACCGCAACCCC 
               
               
                   
               
               
                 ACCATGAACTTGCTGACGGGGGTGCCCAACTCCATGCTCCAGAGCCCCCAGGTCGAGCCCACCCTGC 
               
               
                   
               
               
                 GCCGCAACCAGGAGCAGCTCTACAGCTTCCTGGAGCGCCACTCGCCTTACTTCCGCCGCCACAGCGC 
               
               
                   
               
               
                 ACAGATCAGGAGGGCCACCTCCTTCTGCCACTTGCAAGAGATGCAAGAAGGGTAATAACGATGTACA 
               
               
                   
               
               
                 CACTTTTTTTCTCAATAAATGGCATCTTTTTATTTATACAAGCTCTCTGGGGTATTCATTTCCCACCAC 
               
               
                   
               
               
                 CACCCGCCGTTGTCGCCATCTGGCTCTATTTAGAAATCGAAAGGGTTCTGCCGGGAGTCGCCGTGCGC 
               
               
                   
               
               
                 CACGGGCAGGGACACGTTGCGATACTGGTAGCGGGTGCCCCACTTGAACTCGGGCACCACCAGGCG 
               
               
                   
               
               
                 AGGCAGCTCGGGGAAGTTTTCGCTCCACAGGCTGCGGGTCAGCACCAGCGCGTTCATCAGGTCGGGC 
               
               
                   
               
               
                 GCCGAGATCTTGAAGTCGCAGTTGGGGCCGCCGCCCTGCGCGCGCGAGTTGCGGTACACCGGGTTGC 
               
               
                   
               
               
                 AGCACTGGAACACCAACAGCGCCGGGTGCTTCACGCTGGCCAGCACGCTGCGGTCGGAGATCAGCTC 
               
               
                   
               
               
                 GGCGTCCAGGTCCTCCGCGTTGCTCAGCGCGAACGGGGTCATCTTGGGCACTTGCCGCCCCAGGAAG 
               
               
                   
               
               
                 GGCGCGTGCCCCGGTTTCGAGTTGCAGTCGCAGCGCAGCGGGATCAGCAGGTGCCCGTGCCCGGACT 
               
               
                   
               
               
                 CGGCGTTGGGGTACAGCGCGCGCATGAAGGCCTGCATCTGGCGGAAGGCCATCTGGGCCTTGGCGCC 
               
               
                   
               
               
                 CTCCGAGAAGAACATGCCGCAGGACTTGCCCGAGAACTGGTTTGCGGGGCAGCTGGCGTCGTGCAGG 
               
               
                   
               
               
                 CAGCAGCGCGCGTCGGTGTTGGCGATCTGCACCACGTTGCGCCCCCACCGGTTCTTCACGATCTTGGC 
               
               
                   
               
               
                 CTTGGACGATTGCTCCTTCAGCGCGCGCTGCCCGTTCTCGCTGGTCACATCCATCTCGATCACATGTT 
               
               
                   
               
               
                 CCTTGTTCACCATGCTGCTGCCGTGCAGACACTTCAGCTCGCCCTCCGTCTCGGTGCAGCGGTGCTGC 
               
               
                   
               
               
                 CACAGCGCGCAGCCCGTGGGCTCGAAAGACTTGTAGGTCACCTCCGCGAAGGACTGCAGGTACCCCT 
               
               
                   
               
               
                 GCAAAAAGCGGCCCATCATGGTCACGAAGGTCTTGTTGCTGCTGAAGGTCAGCTGCAGCCCGCGGTG 
               
               
                   
               
               
                 CTCCTCGTTCAGCCAGGTCTTGCACACGGCCGCCAGCGCCTCCACCTGGTCGGGCAGCATCTTGAAGT 
               
               
                   
               
               
                 TCACCTTCAGCTCATTCTCCACGTGGTACTTGTCCATCAGCGTGCGCGCCGCCTCCATGCCCTTCTCCC 
               
               
                   
               
               
                 AGGCCGACACCAGCGGCAGGCTCACGGGGTTCTTCACCATCACCGTGGCCGCCGCCTCCGCCGCGCT 
               
               
                   
               
               
                 TTCGCTTTCCGCCCCGCTGTTCTCTTCCTCTTCCTCCTCTTCCTCGCCGCCGCCCACTCGCAGCCCCCG 
               
               
                   
               
               
                 CACCACGGGGTCGTCTTCCTGCAGGCGCTGCACCTTGCGCTTGCCGTTGCGCCCCTGCTTGATGCGCA 
               
               
                   
               
               
                 CGGGCGGGTTGCTGAAGCCCACCATCACCAGCGCGGCCTCTTCTTGCTCGTCCTCGCTGTCCAGAATG 
               
               
                   
               
               
                 ACCTCCGGGGAGGGGGGGTTGGTCATCCTCAGTACCGAGGCACGCTTCTTTTTCTTCCTGGGGGCGTT 
               
               
                   
               
               
                 CGCCAGCTCCGCGGCTGCGGCCGCTGCCGAGGTCGAAGGCCGAGGGCTGGGCGTGCGCGGCACCAG 
               
               
                   
               
               
                 CGCGTCCTGCGAGCCGTCCTCGTCCTCCTCGGACTCGAGACGGAGGCGGGCCCGCTTCTTCGGGGGC 
               
               
                   
               
               
                 GCGCGGGGCGGCGGAGGCGGCGGCGGCGACGGAGACGGGGACGAGACATCGTCCAGGGTGGGTGG 
               
               
                   
               
               
                 ACGGCGGGCCGCGCCGCGTCCGCGCTCGGGGGTGGTCTCGCGCTGGTCCTCTTCCCGACTGGCCATCT 
               
               
                   
               
               
                 CCCACTGCTCCTTCTCCTATAGGCAGAAAGAGATCATGGAGTCTCTCATGCGAGTCGAGAAGGAGGA 
               
               
                   
               
               
                 GGACAGCCTAACCGCCCCCTCTGAGCCCTCCACCACCGCCGCCACCACCGCCAATGCCGCCGCGGAC 
               
               
                   
               
               
                 GACGCGCCCACCGAGACCACCGCCAGTACCACCCTCCCCAGCGACGCACCCCCGCTCGAGAATGAAG 
               
               
                   
               
               
                 TGCTGATCGAGCAGGACCCGGGTTTTGTGAGCGGAGAGGAGGATGAGGTGGATGAGAAGGAGAAGG 
               
               
                   
               
               
                 AGGAGGTCGCCGCCTCAGTGCCAAAAGAGGATAAAAAGCAAGACCAGGACGACGCAGATAAGGAT 
               
               
                   
               
               
                 GAGACAGCAGTCGGGCGGGGGAACGGAAGCCATGATGCTGATGACGGCTACCTAGACGTGGGAGAC 
               
               
                   
               
               
                 GACGTGCTGCTTAAGCACCTGCACCGCCAGTGCGTCATCGTCTGCGACGCGCTGCAGGAGCGCTGCG 
               
               
                   
               
               
                 AAGTGCCCCTGGACGTGGCGGAGGTCAGCCGCGCCTACGAGCGGCACCTCTTCGCGCCGCACGTGCC 
               
               
                   
               
               
                 CCCCAAGCGCCGGGAGAACGGCACCTGCGAGCCCAACCCGCGTCTCAACTTCTACCCGGTCTTCGCG 
               
               
                   
               
               
                 GTACCCGAGGTGCTGGCCACCTACCACATCTTTTTCCAAAACTGCAAGATCCCCCTCTCCTGCCGCGC 
               
               
                   
               
               
                 CAACCGCACCCGCGCCGACAAAACCCTGACCCTGCGGCAGGGCGCCCACATACCTGATATCGCCTCT 
               
               
                   
               
               
                 CTGGAGGAAGTGCCCAAGATCTTCGAGGGTCTCGGTCGCGACGAGAAACGGGCGGCGAACGCTCTG 
               
               
                   
               
               
                 CACGGAGACAGCGAAAACGAGAGTCACTCGGGGGTGCTGGTGGAGCTCGAGGGCGACAACGCGCGC 
               
               
                   
               
               
                 CTGGCCGTACTCAAGCGCAGCATAGAGGTCACCCACTTTGCCTACCCGGCGCTCAACCTGCCCCCCA 
               
               
                   
               
               
                 AGGTCATGAGTGTGGTCATGGGCGAGCTCATCATGCGCCGCGCCCAGCCCCTGGCCGCGGATGCAAA 
               
               
                   
               
               
                 CTTGCAAGAGTCCTCCGAGGAAGGCCTGCCCGCGGTCAGCGACGAGCAGCTGGCGCGCTGGCTGGA 
               
               
                   
               
               
                 GACCCGCGACCCCGCGCAGCTGGAGGAGCGGCGCAAGCTCATGATGGCCGCGGTGCTGGTCACCGT 
               
               
                   
               
               
                 GGAGCTCGAGTGTCTGCAGCGCTTCTTCGCGGACCCCGAGATGCAGCGCAAGCTCGAGGAGACCCTG 
               
               
                   
               
               
                 CACTACACCTTCCGCCAGGGCTACGTGCGCCAGGCCTGCAAGATCTCCAACGTGGAGCTCTGCAACC 
               
               
                   
               
               
                 TGGTCTCCTACCTGGGCATCCTGCACGAGAACCGCCTCGGGCAGAACGTCCTGCACTCCACCCTCAA 
               
               
                   
               
               
                 AGGGGAGGCGCGCCGCGACTACATCCGCGACTGCGCCTACCTCTTCCTCTGCTACACCTGGCAGACG 
               
               
                   
               
               
                 GCCATGGGGGTCTGGCAGCAGTGCCTGGAGGAGCGCAACCTCAAGGAGCTGGAAAAGCTCCTCAAG 
               
               
                   
               
               
                 CGCACCCTCAGGGACCTCTGGACGGGCTTCAACGAGCGCTCGGTGGCCGCCGCGCTGGCGGACATCA 
               
               
                   
               
               
                 TCTTTCCCGAGCGCCTGCTCAAGACCCTGCAGCAGGGCCTGCCCGACTTCACCAGCCAGAGCATGCT 
               
               
                   
               
               
                 GCAGAACTTCAGGACTTTCATCCTGGAGCGCTCGGGCATCCTGCCGGCCACTTGCTGCGCGCTGCCCA 
               
               
                   
               
               
                 GCGACTTCGTGCCCATCAAGTACAGGGAGTGCCCGCCGCCGCTCTGGGGCCACTGCTACCTCTTCCA 
               
               
                   
               
               
                 GCTGGCCAACTACCTCGCCTACCACTCGGACCTCATGGAAGACGTGAGCGGCGAGGGCCTGCTCGAG 
               
               
                   
               
               
                 TGCCACTGCCGCTGCAACCTCTGCACGCCCCACCGCTCTCTAGTCTGCAACCCGCAGCTGCTCAGCGA 
               
               
                   
               
               
                 GAGTCAGATTATCGGTACCTTCGAGCTGCAGGGTCCCTCGCCTGACGAGAAGTCCGCGGCTCCAGGG 
               
               
                   
               
               
                 CTGAAACTCACTCCGGGGCTGTGGACTTCCGCCTACCTACGCAAATTTGTACCTGAGGACTACCACGC 
               
               
                   
               
               
                 CCACGAGATCAGGTTCTACGAAGACCAATCCCGCCCGCCCAAGGCGGAGCTCACCGCCTGCGTCATC 
               
               
                   
               
               
                 ACCCAGGGGCACATCCTGGGCCAATTGCAAGCCATCAACAAAGCCCGCCGAGAGTTCTTGCTGAAAA 
               
               
                   
               
               
                 AGGGTCGGGGGGTGTACCTGGACCCCCAGTCCGGCGAGGAGCTAAACCCGCTACCCCCGCCGCCGCC 
               
               
                   
               
               
                 CCAGCAGCGGGACCTTGCTTCCCAGGATGGCACCCAGAAAGAAGCAGCAGCCGCCGCCGCCGCCGC 
               
               
                   
               
               
                 AGCCATACATGCTTCTGGAGGAAGAGGAGGAGGACTGGGACAGTCAGGCAGAGGAGGTTTCGGACG 
               
               
                   
               
               
                 AGGAGCAGGAGGAGATGATGGAAGACTGGGAGGAGGACAGCAGCCTAGACGAGGAAGCTTCAGAG 
               
               
                   
               
               
                 GCCGAAGAGGTGGCAGACGCAACACCATCGCCCTCGGTCGCAGCCCCCTCGCCGGGGCCCCTGAAAT 
               
               
                   
               
               
                 CCTCCGAACCCAGCACCAGCGCTATAACCTCCGCTCCTCCGGCGCCGGCGCCACCCGCCCGCAGACC 
               
               
                   
               
               
                 CAACCGTAGATGGGACACCACAGGAACCGGGGTCGGTAAGTCCAAGTGCCCGCCGCCGCCACCGCA 
               
               
                   
               
               
                 GCAGCAGCAGCAGCAGCGCCAGGGCTACCGCTCGTGGCGCGGGCACAAGAACGCCATAGTCGCCTG 
               
               
                   
               
               
                 CTTGCAAGACTGCGGGGGCAACATCTCTTTCGCCCGCCGCTTCCTGCTATTCCACCACGGGGTCGCCT 
               
               
                   
               
               
                 TTCCCCGCAATGTCCTGCATTACTACCGTCATCTCTACAGCCCCTACTGCAGCGGCGACCCAGAGGCG 
               
               
                   
               
               
                 GCAGCGGCAGCCACAGCGGCGACCACCACCTAGGAAGATATCCTCCGCGGGCAAGACAGCGGCAGC 
               
               
                   
               
               
                 AGCGGCCAGGAGACCCGCGGCAGCAGCGGCGGGAGCGGTGGGCGCACTGCGCCTCTCGCCCAACGA 
               
               
                   
               
               
                 ACCCCTCTCGACCCGGGAGCTCAGACACAGGATCTTCCCCACTTTGTATGCCATCTTCCAACAGAGCA 
               
               
                   
               
               
                 GAGGCCAGGAGCAGGAGCTGAAAATAAAAAACAGATCTCTGCGCTCCCTCACCCGCAGCTGTCTGTA 
               
               
                   
               
               
                 TCACAAAAGCGAAGATCAGCTTCGGCGCACGCTGGAGGACGCGGAGGCACTCTTCAGCAAATACTG 
               
               
                   
               
               
                 CGCGCTCACTCTTAAAGACTAGCTCCGCGCCCTTCTCGAATTTAGGCGGGAGAAAACTACGTCATCG 
               
               
                   
               
               
                 CCGGCCGCCGCCCAGCCCGCCCAGCCGAGATGAGCAAAGAGATTCCCACGCCATACATGTGGAGCTA 
               
               
                   
               
               
                 CCAGCCGCAGATGGGACTCGCGGCGGGAGCGGCCCAGGACTACTCCACCCGCATGAACTACATGAG 
               
               
                   
               
               
                 CGCGGGACCCCACATGATCTCACAGGTCAACGGGATCCGCGCCCAGCGAAACCAAATACTGCTGGA 
               
               
                   
               
               
                 ACAGGCGGCCATCACCGCCACGCCCCGCCATAATCTCAACCCCCGAAATTGGCCCGCCGCCCTCGTG 
               
               
                   
               
               
                 TACCAGGAAACCCCCTCCGCCACCACCGTACTACTTCCGCGTGACGCCCAGGCCGAAGTCCAGATGA 
               
               
                   
               
               
                 CTAACTCAGGGGCGCAGCTCGCGGGCGGCTTTCGTCACGGGGCGCGGCCGCTCCGACCAGGTATAAG 
               
               
                   
               
               
                 ACACCTGATGATCAGAGGCCGAGGTATCCAGCTCAACGACGAGTCGGTGAGCTCTTCGCTCGGTCTC 
               
               
                   
               
               
                 CGTCCGGACGGAACTTTCCAGCTCGCCGGATCCGGCCGCTCTTCGTTCACGCCCCGCCAGGCGTACCT 
               
               
                   
               
               
                 GACTCTGCAGACCTCGTCCTCGGAGCCCCGCTCCGGCGGCATCGGAACCCTCCAGTTCGTGGAGGAG 
               
               
                   
               
               
                 TTCGTGCCCTCGGTCTACTTCAACCCCTTCTCGGGACCTCCCGGACGCTACCCCGACCAGTTCATTCC 
               
               
                   
               
               
                 GAACTTTGACGCGGTGAAGGACTCGGCGGACGGCTACGACTGAATGTCAGGTGTCGAGGCAGAGCA 
               
               
                   
               
               
                 GCTTCGCCTGAGACACCTCGAGCACTGCCGCCGCCACAAGTGCTTCGCCCGCGGTTCTGGTGAGTTCT 
               
               
                   
               
               
                 GCTACTTTCAGCTACCCGAGGAGCATACCGAGGGGCCGGCGCACGGCGTCCGCCTGACCACCCAGGG 
               
               
                   
               
               
                 CGAGGTTACCTGTTCCCTCATCCGGGAGTTTACCCTCCGTCCCCTGCTAGTGGAGCGGGAGCGGGGTC 
               
               
                   
               
               
                 CCTGTGTCCTAACTATCGCCTGCAACTGCCCTAACCCTGGATTACATCAAGATCTTTGCTGTCATCTCT 
               
               
                   
               
               
                 GTGCTGAGTTTAATAAACGCTGAGATCAGAATCTACTGGGGCTCCTGTCGCCATCCTGTGAACGCCA 
               
               
                   
               
               
                 CCGTCTTCACCCACCCCGACCAGGCCCAGGCGAACCTCACCTGCGGTCTGCATCGGAGGGCCAAGAA 
               
               
                   
               
               
                 GTACCTCACCTGGTACTTCAACGGCACCCCCTTTGTGGTTTACAACAGCTTCGACGGGGACGGAGTCT 
               
               
                   
               
               
                 CCCTGAAAGACCAGCTCTCCGGTCTCAGCTACTCCATCCACAAGAACACCACCCTCCAACTCTTCCCT 
               
               
                   
               
               
                 CCCTACCTGCCGGGAACCTACGAGTGCGTCACCGGCCGCTGCACCCACCTCACCCGCCTGATCGTAA 
               
               
                   
               
               
                 ACCAGAGCTTTCCGGGAACAGATAACTCCCTCTTCCCCAGAACAGGAGGTGAGCTCAGGAAACTCCC 
               
               
                   
               
               
                 CGGGGACCAGGGCGGAGACGTACCTTCGACCCTTGTGGGGTTAGGATTTTTTATTACCGGGTTGCTG 
               
               
                   
               
               
                 GCTCTTTTAATCAAAGTTTCCTTGAGATTTGTTCTTTCCTTCTACGTGTATGAACACCTCAACCTCCAA 
               
               
                   
               
               
                 TAACTCTACCCTTTCTTCGGAATCAGGTGACTTCTCTGAAATCGGGCTTGGTGTGCTGCTTACTCTGTT 
               
               
                   
               
               
                 GATTTTTTTCCTTATCATACTCAGCCTTCTGTGCCTCAGGCTCGCCGCCTGCTGCGCACACATCTATAT 
               
               
                   
               
               
                 CTACTGCTGGTTGCTCAAGTGCAGGGGTCGCCACCCAAGATGAACAGGTACATGGTCCTATCGATCC 
               
               
                   
               
               
                 TAGGCCTGCTGGCCCTGGCGGCCTGCAGCGCCGCCAAAAAAGAGATTACCTTTGAGGAGCCCGCTTG 
               
               
                   
               
               
                 CAATGTAACTTTCAAGCCCGAGGGTGACCAATGCACCACCCTCGTCAAATGCGTTACCAATCATGAG 
               
               
                   
               
               
                 AGGCTGCGCATCGACTACAAAAACAAAACTGGCCAGTTTGCGGTCTATAGTGTGTTTACGCCCGGAG 
               
               
                   
               
               
                 ACCCCTCTAACTACTCTGTCACCGTCTTCCAGGGCGGACAGTCTAAGATATTCAATTACACTTTCCCT 
               
               
                   
               
               
                 TTTTATGAGTTATGCGATGCGGTCATGTACATGTCAAAACAGTACAACCTGTGGCCTCCCTCTCCCCA 
               
               
                   
               
               
                 GGCGTGTGTGGAAAATACTGGGTCTTACTGCTGTATGGCTTTCGCAATCACTACGCTCGCTCTAATCT 
               
               
                   
               
               
                 GCACGGTGCTATACATAAAATTCAGGCAGAGGCGAATCTTTATCGATGAAAAGAAAATGCCTTGATC 
               
               
                   
               
               
                 GCTAACACCGGCTTTCTATCTGCAGAATGAATGCAATCACCTCCCTACTAATCACCACCACCCTCCTT 
               
               
                   
               
               
                 GCGATTGCCCATGGGTTGACACGAATCGAAGTGCCAGTGGGGTCCAATGTCACCATGGTGGGCCCCG 
               
               
                   
               
               
                 CCGGCAATTCCACCCTCATGTGGGAAAAATTTGTCCGCAATCAATGGGTTCATTTCTGCTCTAACCGA 
               
               
                   
               
               
                 ATCAGTATCAAGCCCAGAGCCATCTGCGATGGGCAAAATCTAACTCTGATCAATGTGCAAATGATGG 
               
               
                   
               
               
                 ATGCTGGGTACTATTACGGGCAGCGGGGAGAAATCATTAATTACTGGCGACCCCACAAGGACTACAT 
               
               
                   
               
               
                 GCTGCATGTAGTCGAGGCACTTCCCACTACCACCCCCACTACCACCTCTCCCACCACCACCACCACTA 
               
               
                   
               
               
                 CTACTACTACTACTACTACTACTACTACTACCACTACCGCTGCCCGCCATACCCGCAAAAGCACCATG 
               
               
                   
               
               
                 ATTAGCACAAAGCCCCCTCGTGCTCACTCCCACGCCGGCGGGCCCATCGGTGCGACCTCAGAAACCA 
               
               
                   
               
               
                 CCGAGCTTTGCTTCTGCCAATGCACTAACGCCAGCGCTCATGAACTGTTCGACCTGGAGAATGAGGA 
               
               
                   
               
               
                 TGTCCAGCAGAGCTCCGCTTGCCTGACCCAGGAGGCTGTGGAGCCCGTTGCCCTGAAGCAGATCGGT 
               
               
                   
               
               
                 GATTCAATAATTGACTCTTCTTCTTTTGCCACTCCCGAATACCCTCCCGATTCTACTTTCCACATCACG 
               
               
                   
               
               
                 GGTACCAAAGACCCTAACCTCTCTTTCTACCTGATGCTGCTGCTCTGTATCTCTGTGGTCTCTTCCGCG 
               
               
                   
               
               
                 CTGATGTTACTGGGGATGTTCTGCTGCCTGATCTGCCGCAGAAAGAGAAAAGCTCGCTCTCAGGGCC 
               
               
                   
               
               
                 AACCACTGATGCCCTTCCCCTACCCCCCGGATTTTGCAGATAACAAGATATGAGCTCGCTGCTGACAC 
               
               
                   
               
               
                 TAACCGCTTTACTAGCCTGCGCTCTAACCCTTGTCGCTTGCGACTCGAGATTCCACAATGTCACAGCT 
               
               
                   
               
               
                 GTGGCAGGAGAAAATGTTACTTTCAACTCCACGGCCGATACCCAGTGGTCGTGGAGTGGCTCAGGTA 
               
               
                   
               
               
                 GCTACTTAACTATCTGCAATAGCTCCACTTCCCCCGGCATATCCCCAACCAAGTACCAATGCAATGCC 
               
               
                   
               
               
                 AGCCTGTTCACCCTCATCAACGCTTCCACCCTGGACAATGGACTCTATGTAGGCTATGTACCCTTTGG 
               
               
                   
               
               
                 TGGGCAAGGAAAGACCCACGCTTACAACCTGGAAGTTCGCCAGCCCAGAACCACTACCCAAGCTTCT 
               
               
                   
               
               
                 CCCACCACCACCACCACCACCACCATCACCAGCAGCAGCAGCAGCAGCAGCCACAGCAGCAGCAGC 
               
               
                   
               
               
                 AGATTATTGACTTTGGTTTTGGCCAGCTCATCTGCCGCTACCCAGGCCATCTACAGCTCTGTGCCCGA 
               
               
                   
               
               
                 AACCACTCAGATCCACCGCCCAGAAACGACCACCGCCACCACCCTACACACCTCCAGCGATCAGATG 
               
               
                   
               
               
                 CCGACCAACATCACCCCCTTGGCTCTTCAAATGGGACTTACAAGCCCCACTCCAAAACCAGTGGATG 
               
               
                   
               
               
                 CGGCCGAGGTCTCCGCCCTCGTCAATGACTGGGCGGGGCTGGGAATGTGGTGGTTCGCCATAGGCAT 
               
               
                   
               
               
                 GATGGCGCTCTGCCTGCTTCTGCTCTGGCTCATCTGCTGCCTCCACCGCAGGCGAGCCAGACCCCCCA 
               
               
                   
               
               
                 TCTATAGACCCATCATTGTCCTGAACCCCGATAATGATGGGATCCATAGATTGGATGGCCTGAAAAA 
               
               
                   
               
               
                 CCTACTTTTTTCTTTTACAGTATGATAAATTGAGACATGCCTCGCATTTTCTTGTACATGTTCCTTCTCC 
               
               
                   
               
               
                 CACCTTTTCTGGGGTGTTCTACGCTGGCCGCTGTGTCTCACCTGGAGGTAGACTGCCTCTCACCCTTC 
               
               
                   
               
               
                 ACTGTCTACCTGCTTTACGGATTGGTCACCCTCACTCTCATCTGCAGCCTAATCACAGTAATCATCGC 
               
               
                   
               
               
                 CTTCATCCAGTGCATTGATTACATCTGTGTGCGCCTCGCATACTTCAGACACCACCCGCAGTACCGAG 
               
               
                   
               
               
                 ACAGGAACATTGCCCAACTTCTAAGACTGCTCTAATCATGCATAAGACTGTGATCTGCCTTCTGATCC 
               
               
                   
               
               
                 TCTGCATCCTGCCCACCCTCACCTCCTGCCAGTACACCACAAAATCTCCGCGCAAAAGACATGCCTCC 
               
               
                   
               
               
                 TGCCGCTTCACCCAACTGTGGAATATACCCAAATGCTACAACGAAAAGAGCGAGCTCTCCGAAGCTT 
               
               
                   
               
               
                 GGCTGTATGGGGTCATCTGTGTCTTAGTTTTCTGCAGCACTGTCTTTGCCCTCATAATCTACCCCTACT 
               
               
                   
               
               
                 TTGATTTGGGATGGAACGCGATCGATGCCATGAATTACCCCACCTTTCCCGCACCCGAGATAATTCCA 
               
               
                   
               
               
                 CTGCGACAAGTTGTACCCGTTGTCGTTAATCAACGCCCCCCATCCCCTACGCCCACTGAAATCAGCTA 
               
               
                   
               
               
                 CTTTAACCTAACAGGCGGAGATGACTGACGCCCTAGATCTAGAAATGGACGGCATCAGTACCGAGCA 
               
               
                   
               
               
                 GCGTCTCCTAGAGAGGCGCAGGCAGGCGGCTGAGCAAGAGCGCCTCAATCAGGAGCTCCGAGATCT 
               
               
                   
               
               
                 CGTTAACCTGCACCAGTGCAAAAGAGGCATCTTTTGTCTGGTAAAGCAGGCCAAAGTCACCTACGAG 
               
               
                   
               
               
                 AAGACCGGCAACAGCCACCGCCTCAGTTACAAATTGCCCACCCAGCGCCAGAAGCTGGTGCTCATGG 
               
               
                   
               
               
                 TGGGTGAGAATCCCATCACCGTCACCCAGCACTCGGTAGAGACCGAGGGGTGTCTGCACTCCCCCTG 
               
               
                   
               
               
                 TCGGGGTCCAGAAGACCTCTGCACCCTGGTAAAGACCCTGTGCGGTCTCAGAGATTTAGTCCCCTTTA 
               
               
                   
               
               
                 ACTAATCAAACACTGGAATCAATAAAAAGAATCACTTACTTAAAATCAGACAGCAGGTCTCTGTCCA 
               
               
                   
               
               
                 GTTTATTCAGCAGCACCTCCTTCCCCTCCTCCCAACTCTGGTACTCCAAACGCCTTCTGGCGGCAAAC 
               
               
                   
               
               
                 TTCCTCCACACCCTGAAGGGAATGTCAGATTCTTGCTCCTGTCCCTCCGCACCCACTATCTTCATGTTG 
               
               
                   
               
               
                 TTGCAGATGAAGCGCACCAAAACGTCTGACGAGAGCTTCAACCCCGTGTACCCCTATGACACGGAAA 
               
               
                   
               
               
                 GCGGCCCTCCCTCCGTCCCTTTCCTCACCCCTCCCTTCGTGTCTCCCGATGGATTCCAAGAAAGTCCCC 
               
               
                   
               
               
                 CCGGGGTCCTGTCTCTGAACCTGGCCGAGCCCCTGGTCACTTCCCACGGCATGCTCGCCCTGAAAATG 
               
               
                   
               
               
                 GGAAGTGGCCTCTCCCTGGACGACGCTGGCAACCTCACCTCTCAAGATATCACCACCGCTAGCCCTC 
               
               
                   
               
               
                 CCCTCAAAAAAACCAAGACCAACCTCAGCCTAGAAACCTCATCCCCCCTAACTGTGAGCACCTCAGG 
               
               
                   
               
               
                 CGCCCTCACCGTAGCAGCCGCCGCTCCCCTGGCGGTGGCCGGCACCTCCCTCACCATGCAATCAGAG 
               
               
                   
               
               
                 GCCCCCCTGACAGTACAGGATGCAAAACTCACCCTGGCCACCAAAGGCCCCCTGACCGTGTCTGAAG 
               
               
                   
               
               
                 GCAAACTGGCCTTGCAAACATCGGCCCCGCTGACGGCCGCTGACAGCAGCACCCTCACAGTCAGTGC 
               
               
                   
               
               
                 CACACCACCCCTTAGCACAAGCAATGGCAGCTTGGGTATTGACATGCAAGCCCCCATTTACACCACC 
               
               
                   
               
               
                 AATGGAAAACTAGGACTTAACTTTGGCGCTCCCCTGCATGTGGTAGACAGCCTAAATGCACTGACTG 
               
               
                   
               
               
                 TAGTTACTGGCCAAGGTCTTACGATAAACGGAACAGCCCTACAAACTAGAGTCTCAGGTGCCCTCAA 
               
               
                   
               
               
                 CTATGACACATCAGGAAACCTAGAATTGAGAGCTGCAGGGGGTATGCGAGTTGATGCAAATGGTCA 
               
               
                   
               
               
                 ACTTATCCTTGATGTAGCTTACCCATTTGATGCACAAAACAATCTCAGCCTTAGGCTTGGACAGGGAC 
               
               
                   
               
               
                 CCCTGTTTGTTAACTCTGCCCACAACTTGGATGTTAACTACAACAGAGGCCTCTACCTGTTCACATCT 
               
               
                   
               
               
                 GGAAATACCAAAAAGCTAGAAGTTAATATCAAAACAGCCAAGGGTCTCATTTATGATGACACTGCTA 
               
               
                   
               
               
                 TAGCAATCAATGCGGGTGATGGGCTACAGTTTGACTCAGGCTCAGATACAAATCCATTAAAAACTAA 
               
               
                   
               
               
                 ACTTGGATTAGGACTGGATTATGACTCCAGCAGAGCCATAATTGCTAAACTGGGAACTGGCCTAAGC 
               
               
                   
               
               
                 TTTGACAACACAGGTGCCATCACAGTAGGCAACAAAAATGATGACAAGCTTACCTTGTGGACCACAC 
               
               
                   
               
               
                 CAGACCCATCCCCTAACTGTAGAATCTATTCAGAGAAAGATGCTAAATTCACACTTGTTTTGACTAAA 
               
               
                   
               
               
                 TGCGGCAGTCAGGTGTTGGCCAGCGTTTCTGTTTTATCTGTAAAAGGTAGCCTTGCGCCCATCAGTGG 
               
               
                   
               
               
                 CACAGTAACTAGTGCTCAGATTGTCCTCAGATTTGATGAAAATGGAGTTCTACTAAGCAATTCTTCCC 
               
               
                   
               
               
                 TTGACCCTCAATACTGGAACTACAGAAAAGGTGACCTTACAGAGGGCACTGCATATACCAACGCAGT 
               
               
                   
               
               
                 GGGATTTATGCCCAACCTCACAGCATACCCAAAAACACAGAGCCAAACTGCTAAAAGCAACATTGTA 
               
               
                   
               
               
                 AGTCAGGTTTACTTGAATGGGGACAAATCCAAACCCATGACCCTCACCATTACCCTCAATGGAACTA 
               
               
                   
               
               
                 ATGAAACAGGAGATGCCACAGTAAGCACTTACTCCATGTCATTCTCATGGAACTGGAATGGAAGTAA 
               
               
                   
               
               
                 TTACATTAATGAAACGTTCCAAACCAACTCCTTCACCTTCTCCTACATCGCCCAAGAATAAAAAGCAT 
               
               
                   
               
               
                 GACGCTGTTGATTTGATTCAATGTGTTTCTGTTTTATTTTCAAGCACAACAAAATCATTCAAGTCATTC 
               
               
                   
               
               
                 TTCCATCTTAGCTTAATAGACACAGTAGCTTAATAGACCCAGTAGTGCAAAGCCCCATTCTAGCTTAT 
               
               
                   
               
               
                 AACTAGTGGAGAAGTACTCGCCTACATGGGGGTAGAGTCATAATCGTGCATCAGGATAGGGCGGTG 
               
               
                   
               
               
                 GTGCTGCAGCAGCGCGCGAATAAACTGCTGCCGCCGCCGCTCCGTCCTGCAGGAATACAACATGGCA 
               
               
                   
               
               
                 GTGGTCTCCTCAGCGATGATTCGCACCGCCCGCAGCATAAGGCGCCTTGTCCTCCGGGCACAGCAGC 
               
               
                   
               
               
                 GCACCCTGATCTCACTTAAATCAGCACAGTAACTGCAGCACAGCACCACAATATTGTTCAAAATCCC 
               
               
                   
               
               
                 ACAGTGCAAGGCGCTGTATCCAAAGCTCATGGCGGGGACCACAGAACCCACGTGGCCATCATACCAC 
               
               
                   
               
               
                 AAGCGCAGGTAGATTAAGTGGCGACCCCTCATAAACACGCTGGACATAAACATTACCTCTTTTGGCA 
               
               
                   
               
               
                 TGTTGTAATTCACCACCTCCCGGTACCATATAAACCTCTGATTAAACATGGCGCCATCCACCACCATC 
               
               
                   
               
               
                 CTAAACCAGCTGGCCAAAACCTGCCCGCCGGCTATACACTGCAGGGAACCGGGACTGGAACAATGA 
               
               
                   
               
               
                 CAGTGGAGAGCCCAGGACTCGTAACCATGGATCATCATGCTCGTCATGATATCAATGTTGGCACAAC 
               
               
                   
               
               
                 ACAGGCACACGTGCATACACTTCCTCAGGATTACAAGCTCCTCCCGCGTTAGAACCATATCCCAGGG 
               
               
                   
               
               
                 AACAACCCATTCCTGAATCAGCGTAAATCCCACACTGCAGGGAAGACCTCGCACGTAACTCACGTTG 
               
               
                   
               
               
                 TGCATTGTCAAAGTGTTACATTCGGGCAGCAGCGGATGATCCTCCAGTATGGTAGCGCGGGTTTCTGT 
               
               
                   
               
               
                 CTCAAAAGGAGGTAGACGATCCCTACTGTACGGAGTGCGCCGAGACAACCGAGATCGTGTTGGTCGT 
               
               
                   
               
               
                 AGTGTCATGCCAAATGGAACGCCGGACGTAGTCATATTTCCTGAAGTCTTAGATCTCTCAACGCAGC 
               
               
                   
               
               
                 ACCAGCACCAACACTTCGCAGTGTAAAAGGCCAAGTGCCGAGAGAGTATATATAGGAATAAAAAGT 
               
               
                   
               
               
                 GACGTAAACGGGCAAAGTCCAAAAAACGCCCAGAAAAACCGCACGCGAACCTACGCCCCGAAACGA 
               
               
                   
               
               
                 AAGCCAAAAAACACTAGACACTCCCTTCCGGCGTCAACTTCCGCTTTCCCACGCTACGTCACTTGCCC 
               
               
                   
               
               
                 CAGTCAAACAAACTACATATCCCGAACTTCCAAGTCGCCACGCCCAAAACACCGCCTACACCTCCCC 
               
               
                   
               
               
                 GCCCGCCGGCCCGCCCCCAAACCCGCCTCCCGCCCCGCGCCCCGCCCCGCGCCGCCCATCTCATTATC 
               
               
                   
               
               
                 ATATTGGCTTCAATCCAAAATAAGGTATATTATTGATGATG 
               
               
                   
               
               
                 Polynucleotide sequence encoding the CASI promoter 
               
               
                 SEQ ID NO: 12 
                   
               
               
                 GGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCA 
                   
               
               
                   
               
               
                 TTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGT 
               
               
                   
               
               
                 GGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCT 
               
               
                   
               
               
                 ATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCC 
               
               
                   
               
               
                 TACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTCGAGGTGAGCCCCACGTTCTGCT 
               
               
                   
               
               
                 TCACTCTCCCCATCTCCCCCCCCTCCCCACCCCCAATTTTGTATTTATTTATTTTTTAATTATTTTGTGC 
               
               
                   
               
               
                 AGCGATGGGGGCGGGGGGGGGGGGGGGCGCGCGCCAGGCGGGGCGGGGCGGGGCGAGGGGCGGGG 
               
               
                   
               
               
                 CGGGGCGAGGCGGAGAGGTGCGGCGGCAGCCAATCAGAGCGGCGCGCTCCGAAAGTTTCCTTTTAT 
               
               
                   
               
               
                 GGCGAGGCGGCGGCGGCGGCGGCCCTATAAAAAGCGAAGCGCTCCCTATCAGTGATAGAGATCTCC 
               
               
                   
               
               
                 CTATCAGTGATAGAGATCGTCGACGAGCTCGCGGCGGGCGGGAGTCGCTGCGCGCTGCCTTCGCCCC 
               
               
                   
               
               
                 GTGCCCCGCTCCGCCGCCGCCTCGCGCCGCCCGCCCCGGCTCTGACTGACCGCGTTACTAAAACAGG 
               
               
                   
               
               
                 TAAGTCCGGCCTCCGCGCCGGGTTTTGGCGCCTCCCGCGGGCGCCCCCCTCCTCACGGCGAGCGCTGC 
               
               
                   
               
               
                 CACGTCAGACGAAGGGCGCAGCGAGCGTCCTGATCCTTCCGCCCGGACGCTCAGGACAGCGGCCCGC 
               
               
                   
               
               
                 TGCTCATAAGACTCGGCCTTAGAACCCCAGTATCAGCAGAAGGACATTTTAGGACGGGACTTGGGTG 
               
               
                   
               
               
                 ACTCTAGGGCACTGGTTTTCTTTCCAGAGAGCGGAACAGGCGAGGAAAAGTAGTCCCTTCTCGGCGA 
               
               
                   
               
               
                 TTCTGCGGAGGGATCTCCGTGGGGCGGTGAACGCCGATGATGCCTCTACTAACCATGTTCATGTTTTC 
               
               
                   
               
               
                 TTTTTTTTTCTACAGGTCCTGGGTGACGAACAG 
               
               
                   
               
               
                 Ad5orf6 primer 1 polynucleotide sequence 
               
               
                 SEQ ID NO: 13 
                   
               
               
                 ATACGGACTAGTGGAGAAGTACTCGCCTACATG 
                   
               
               
                   
               
               
                 Ad5orf6 primer 2 polynucleotide sequence 
               
               
                 SEQ ID NO: 14 
                   
               
               
                 ATACGGAAGATCTAAGACTTCAGGAAATATGACTAC 
                   
               
               
                   
               
               
                 BAC/CHAd155 ΔE1_TetO hCMV RpsL-Kana primer 
               
               
                 1 polynucleotide sequence 
               
               
                 SEQ ID NO: 15 
                   
               
               
                 ATTCAGTGTACAGGCGCGCCAAAGCATGACGCTGTTGATTTGATTC 
                   
               
               
                   
               
               
                 BAC/CHAd155 ΔE1_TetO hCMV RpsL-Kana 
               
               
                 (#1375) primer 2 polynucleotide sequence 
               
               
                 SEQ ID NO: 16 
                   
               
               
                 ACTAGGACTAGTTATAAGCTAGAATGGGGCTTTGC 
                   
               
               
                   
               
               
                 1021-FW E4 Del Step1 primer polynucleotide sequence 
               
               
                 SEQ ID NO: 17 
                   
               
               
                 TTAATAGACACAGTAGCTTAATAGACCCAGTAGTGCAAAGCCCCATTCTAGCTTATAACCCCTATTTG 
                   
               
               
                   
               
               
                 TTTATTTTTCT 
               
               
                   
               
               
                 1022-RW E4 Del Step1 primer polynucleotide sequence 
               
               
                 SEQ ID NO: 18 
                   
               
               
                 ATATATACTCTCTCGGCACTTGGCCTTTTACACTGCGAAGTGTTGGTGCTGGTGCTGCGTTGAGAGAT 
                   
               
               
                   
               
               
                 CTTTATTTGTTAACTGTTAATTGTC 
               
               
                   
               
               
                 1025-FW E4 Del Step2 primer polynucleotide sequence 
               
               
                 SEQ ID NO: 19 
                   
               
               
                 TTAATAGACACAGTAGCTTAATA 
                   
               
               
                   
               
               
                 1026-RW E4 Del Step2 primer polynucleotide sequence 
               
               
                 SEQ ID NO: 20 
                   
               
               
                 GGAAGGGAGTGTCTAGTGTT 
                   
               
               
                   
               
               
                 91-SubMonte FW primer polynucleotide sequence 
               
               
                 SEQ ID NO: 21 
                   
               
               
                 CAATGGGCGTGGATAGCGGTTTGAC 
                   
               
               
                   
               
               
                 90-BghPolyA RW primer polynucleotide sequence 
               
               
                 SEQ ID NO: 22 
                   
               
               
                 CAGCATGCCTGCTATTGTC 
                   
               
               
                   
               
               
                 CMVfor primer polynucleotide sequence 
               
               
                 SEQ ID NO: 23 
                   
               
               
                 CATCTACGTATTAGTCATCGCTATTACCA 
                   
               
               
                   
               
               
                 CMVrev primer polynucleotide sequence 
               
               
                 SEQ ID NO: 24 
                   
               
               
                 GACTTGGAAATCCCCGTGAGT 
                   
               
               
                   
               
               
                 CMVFAM-TAMRA qPCR probe polynucleotide sequence 
               
               
                 SEQ ID NO: 25 
                   
               
               
                 ACATCAATGGGCGTGGATAGCGGTT 
                   
               
               
                   
               
               
                 Woodchuck Hepatitis Virus Posttranscriptional Regulatory 
               
               
                 Element (WPRE) polynucleotide sequence 
               
               
                 SEQ ID NO: 26 
                   
               
               
                 TAATCAACCTCTGGATTACAAAATTTGTGAAAGATTGACTGGTATTCTTAACTATGTTGCTCCTTTTAC 
                   
               
               
                   
               
               
                 GCTATGTGGATACGCTGCTTTAATGCCTTTGTATCATGCTATTGCTTCCCGTATGGCTTTCATTTTCTC 
               
               
                   
               
               
                 CTCCTTGTATAAATCCTGGTTGCTGTCTCTTTATGAGGAGTTGTGGCCCGTTGTCAGGCAACGTGGCG 
               
               
                   
               
               
                 TGGTGTGCACTGTGTTTGCTGACGCAACCCCCACTGGTTGGGGCATTGCCACCACCTGTCAGCTCCTT 
               
               
                   
               
               
                 TCCGGGACTTTCGCTTTCCCCCTCCCTATTGCCACGGCGGAACTCATCGCCGCCTGCCTTGCCCGCTG 
               
               
                   
               
               
                 CTGGACAGGGGCTCGGCTGTTGGGCACTGACAATTCCGTGGTGTTGTCGGGGAAATCATCGTCCTTTC 
               
               
                   
               
               
                 CTTGGCTGCTCGCCTGTGTTGCCACCTGGATTCTGCGCGGGACGTCCTTCTGCTACGTCCCTTCGGCCC 
               
               
                   
               
               
                 TCAATCCAGCGGACCTTCCTTCCCGCGGCCTGCTGCCGGCTCTGCGGCCTCTTCCGCGTCTTCGCCTTC 
               
               
                   
               
               
                 GCCCTCAGACGAGTCGGATCTCCCTTTGGGCCGCCTCCCCGCCT 
               
               
                   
               
               
                 ChAd3 fiber amino acid sequence 
               
               
                 SEQ ID NO: 27 
                   
               
               
                 MKRTKTSDESFNPVYPYDTESGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS 
                   
               
               
                   
               
               
                 LDDAGNLTSQDITTASPPLKKTKTNLSLETSSPLTVSTSGALTVAAAAPLAVAGTSLTMQSEAPLTVQDAK 
               
               
                   
               
               
                 LTLATKGPLTVSEGKLALQTSAPLTAADSSTLTVSATPPINVSSGSLGLDMEDPMYTHDGKLGIRIGGPLR 
               
               
                   
               
               
                 VVDSLHTLTVVTGNGLTVDNNALQTRVTGALGYDTSGNLQLRAAGGMRIDANGQLILNVAYPFDAQNN 
               
               
                   
               
               
                 LSLRLGQGPLYINTDHNLDLNCNRGLTTTTTNNTKKLETKISSGLDYDTNGAVIIKLGTGLSFDNTGALTV 
               
               
                   
               
               
                 GNTGDDKLTLWTTPDPSPNCRIHSDKDCKFTLVLTKCGSQILASVAALAVSGNLASITGTVASVTIFLRFD 
               
               
                   
               
               
                 QNGVLMENSSLDRQYWNFRNGNSTNAAPYTNAVGFMPNLAAYPKTQSQTAKNNIVSQVYLNGDKSKP 
               
               
                   
               
               
                 MTLTITLNGTNESSETSQVSHYSMSFTWAWESGQYATETFATNSFTFSYIAEQ 
               
               
                   
               
               
                 PanAd3 fiber amino acid sequence 
               
               
                 SEQ ID NO: 28 
                   
               
               
                 MKRAKTSDETFNPVYPYDTENGPPSVPFLTPPFVSPDGFQESPPGVLSLRLSEPLVTSHGMLALKMGNGLS 
                   
               
               
                   
               
               
                 LDDAGNLTSQDVTTVTPPLKKTKTNLSLQTSAPLTVSSGSLTVAAAAPLAVAGTSLTMQSQAPLTVQDAK 
               
               
                   
               
               
                 LGLATQGPLTVSEGKLTLQTSAPLTAADSSTLTVGTTPPISVSSGSLGLDMEDPMYTHDGKLGIRIGGPLQ 
               
               
                   
               
               
                 VVDSLHTLTVVTGNGITVANNALQTKVAGALGYDSSGNLELRAAGGMRINTGGQLILDVAYPFDAQNNL 
               
               
                   
               
               
                 SLRLGQGPLYVNTNHNLDLNCNRGLTTTTSSNTTKLETKIDSGLDYNANGAIIAKLGTGLTFDNTGAITVG 
               
               
                   
               
               
                 NTGDDKLTLWTTPDPSPNCRIHADKDKFTLVLTKCGSQILASVAALAVSGNLSSMTGTVSSVTIFLRFDQN 
               
               
                   
               
               
                 GVLMENSSLDKEYWNFRNGNSTNATPYTNAVGFMPNLSAYPKTQSQTAKNNIVSEVYLHGDKSKPMILT 
               
               
                   
               
               
                 ITLNGTNESSETSQVSHYSMSFTWSWDSGKYATETFATNSFTFSYIAEQ 
               
               
                   
               
               
                 ChAd17 fiber amino acid sequence 
               
               
                 SEQ ID NO: 29 
                   
               
               
                 MKRTKTSDESFNPVYPYDTESGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS 
                   
               
               
                   
               
               
                 LDDAGNLTSQDITSTTPPLKKTKTNLSLETSSPLTVSTSGALTVAAAAPLAVAGTSLTMQSEAPLAVQDAK 
               
               
                   
               
               
                 LTLATKGPLTVSEGKLALQTSAPLTAADSSTLTVSSTPPISVSSGSLGLDMEDPMYTHDGKLGIRIGGPLRV 
               
               
                   
               
               
                 VDSLHTLTVVTGNGLTVDNNALQTRVTGALGYDTSGNLQLRAAGGMRIDANGQLILDVAYPFDAQNNL 
               
               
                   
               
               
                 SLRLGQGPLYVNTDHNLDLNCNRGLTTTTTNNTKKLETKISSGLDYDTNGAVIIKLGTGLSFDNTGALTV 
               
               
                   
               
               
                 GNTGDDKLTLWTTPDPSPNCRIHSDKDCKFTLVLTKCGSQILASVAALAVSGNLASITGTVASVTIFLRFD 
               
               
                   
               
               
                 QNGVLMENSSLDKQYWNFRNGNSTNAAPYTNAVGFMPNLAAYPKTQSQTAKNNIVSQVYLNGDKSKP 
               
               
                   
               
               
                 MTLTITLNGTNESSETSQVSHYSMSFTWAWESGQYATETFATNSFTFSYIAEQ 
               
               
                   
               
               
                 ChAd19 fiber amino acid sequence 
               
               
                 SEQ ID NO: 30 
                   
               
               
                 MKRTKTSDKSFNPVYPYDTENGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS 
                   
               
               
                   
               
               
                 LDDAGNLTSQDVTTTTPPLKKTKTNLSLETSAPLTVSTSGALTLAAAAPLAVAGTSLTMQSEAPLTVQDA 
               
               
                   
               
               
                 KLTLATKGPLTVSEGKLALQTSAPLTAADSSTLTVSATPPISVSSGSLGLDMEDPMYTHDGKLGIRTGGPLR 
               
               
                   
               
               
                 VVDSLHTLTVVTGNGIAVDNNALQTRVTGALGYDTSGNLQLRAAGGMRIDANGQLILDVAYPFDAQNN 
               
               
                   
               
               
                 LSLRLGQGPLYVNTDHNLDLNCNRGLTTTTTNNTKKLETKIGSGLDYDTNGAVIIKLGTGVSFDSTGALS 
               
               
                   
               
               
                 VGNTGDDKLTLWTTPDPSPNCRIHSDKDCKFTLVLTKCGSQILASVAALAVSGNLASITGTVSSVTIFLRFD 
               
               
                   
               
               
                 QNGVLMENSSLDKQYWNFRNGNSTNATPYTNAVGFMPNLAAYPKTQSQTAKNNIVSQVYLNGDKSKP 
               
               
                   
               
               
                 MTLTITLNGTNESSETSQVSHYSMSFTWAWESGQYATETFATNSFTFSYIAEQ 
               
               
                   
               
               
                 ChAd24 fiber amino acid sequence 
               
               
                 SEQ ID NO: 31 
                   
               
               
                 MKRTKTSDESFNPVYPYDTENGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS 
                   
               
               
                   
               
               
                 LDDAGNLTSQDVTTTTPPLKKTKTNLSLETSAPLTVSTSGALTLAAAAPLAVAGTSLTMQSEAPLTVQDA 
               
               
                   
               
               
                 KLTLATKGPLTVSEGKLALQTSAPLTAADSSTLTVSATPPINVSSGSLGLDMENPMYTHDGKLGIRTGGPL 
               
               
                   
               
               
                 RVVDSLHTLTVVTGNGIAVDNNALQTRVTGALGYDTSGNLQLRAAGGMRIDANGQLILDVAYPFDAQN 
               
               
                   
               
               
                 NLSLRLGQGPLYVNTDHNLDLNCNRGLTTTTTNNTKKLETKIGSGLDYDTNGAVIIKLGTGVSFDSTGAL 
               
               
                   
               
               
                 SVGNTGDDKLTLWTTPDPSPNCRIHSDKDCKFTLVLTKCGSQILASVAALAVSGNLASITGTVSSVTIFLRF 
               
               
                   
               
               
                 DQNGVLMENSSLDKQYWNFRNGNSTNATPYTNAVGFMPNLAAYPKTQSQTAKNNIVSQVYLNGDKSKP 
               
               
                   
               
               
                 MILTITLNGTNESSETSQVSHYSMSFTWAWESGQYATETFATNSFTFSYIAEQ 
               
               
                   
               
               
                 ChAd11 fiber amino acid sequence 
               
               
                 SEQ ID NO: 32 
                   
               
               
                 MKRTKTSDESFNPVYPYDTENGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS 
                   
               
               
                   
               
               
                 LDDAGNLTSQDVTTTTPPLKKTKTNLSLETSAPLTVSTSGALTLAAAVPLAVAGTSLTMQSEAPLTVQDA 
               
               
                   
               
               
                 KLTLATKGPLTVSEGKLALQTSAPLTAADSSTLTISATPPLSTSNGSLGIDMQAPIYTTNGKLGLNFGAPLH 
               
               
                   
               
               
                 VVDSLNALTVVTGQGLTINGTALQTRVSGALNYDSSGNLELRAAGGMRVDANGKLILDVAYPFDAQNN 
               
               
                   
               
               
                 LSLRLGQGPLFVNSAHNLDVNYNRGLYLFTSGNTKKLEVNIKTAKGLIYDDTAIAINPGDGLEFGSGSDTN 
               
               
                   
               
               
                 PLKTKLGLGLEYDSSRAIIAKLGTGLSFDNTGAITVGNKNDDKLTLWTTPDPSPNCRIYSEKDAKFTLVLT 
               
               
                   
               
               
                 KCGSQVLASVSVLSVKGSLAPISGTVTSAQIILRFDENGVLLSNSSLDPQYWNYRKGDLTEGTAYTNAVGF 
               
               
                   
               
               
                 MPNLTAYPKTQSQTAKSNIVSQVYLNGDKSKPMILTITLNGTNETGDATVSTYSMSFSWNWNGSNYINET 
               
               
                   
               
               
                 FQTNSFTFSYIAQE 
               
               
                   
               
               
                 ChAd20 fiber amino acid sequence 
               
               
                 SEQ ID NO: 33 
                   
               
               
                 MKRTKTSDESFNPVYPYDTESGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS 
                   
               
               
                   
               
               
                 LDDAGNLTSQDITTASPPLKKTKTNLSLETSSPLTVSTSGALTVAAAAPLAVAGTSLTMQSEAPLTVQDAK 
               
               
                   
               
               
                 LTLATKGPLTVSEGKLALQTSAPLTAADSSTLTVSATPPLSTSNGSLGIDMQAPIYTTNGKLGLNFGAPLH 
               
               
                   
               
               
                 VVDSLNALTVVTGQGLTINGTALQTRVSGALNYDTSGNLELRAAGGMRVDANGQLILDVAYPFDAQNN 
               
               
                   
               
               
                 LSLRLGQGPLFVNSAHNLDVNYNRGLYLFTSGNTKKLEVNIKTAKGLIYDDTAIAINAGDGLQFDSGSDT 
               
               
                   
               
               
                 NPLKTKLGLGLDYDSSRAIIAKLGTGLSFDNTGAITVGNKNDDKLTLWTTPDPSPNCRIYSEKDAKFTLVL 
               
               
                   
               
               
                 TKCGSQVLASVSVLSVKGSLAPISGTVTSAQIVLRFDENGVLLSNSSLDPQYWNYRKGDLTEGTAYTNAV 
               
               
                   
               
               
                 GFMPNLTAYPKTQSQTAKSNIVSQVYLNGDKSKPMTLTITLNGTNETGDATVSTYSMSFSWNWNGSNYI 
               
               
                   
               
               
                 NETFQTNSFTFSYIAQE 
               
               
                   
               
               
                 ChAd31 fiber amino acid sequence 
               
               
                 SEQ ID NO: 34 
                   
               
               
                 MKRTKTSDESFNPVYPYDTESGPPSVPFLTPPFVSPDGFQESPPGVLSLNLAEPLVTSHGMLALKMGSGLS 
                   
               
               
                   
               
               
                 LDDAGNLTSQDITTASPPLKKTKTNLSLETSSPLTVSTSGALTVAAAAPLAVAGTSLTMQSEAPLTVQDAK 
               
               
                   
               
               
                 LTLATKGPLTVSEGKLALQTSAPLTAADSSTLTVSATPPLSTSNGSLGIDMQAPIYTTNGKLGLNFGAPLH 
               
               
                   
               
               
                 VVDSLNALTVVTGQGLTINGTALQTRVSGALNYDTSGNLELRAAGGMRVDANGQLILDVAYPFDAQNN 
               
               
                   
               
               
                 LSLRLGQGPLFVNSAHNLDVNYNRGLYLFTSGNTKKLEVNIKTAKGLIYDDTAIAINAGDGLQFDSGSDT 
               
               
                   
               
               
                 NPLKTKLGLGLDYDSSRAIIAKLGTGLSFDNTGAITVGNKNDDKLTLWTTPDPSPNCRIYSEKDAKFTLVL 
               
               
                   
               
               
                 TKCGSQVLASVSVLSVKGSLAPISGTVTSAQIVLRFDENGVLLSNSSLDPQYWNYRKGDLTEGTAYTNAV 
               
               
                   
               
               
                 GFMPNLTAYPKTQSQTAKSNIVSQVYLNGDKSKPMTLTITLNGTNETGDATVSTYSMSFSWNWNGSNYI 
               
               
                   
               
               
                 NETFQTNSFTFSYIAQE 
               
               
                   
               
               
                 PanAd1 fiber amino acid sequence 
               
               
                 SEQ ID NO: 35 
                   
               
               
                 MKRAKTSDETFNPVYPYDTENGPPSVPFLTPPFVSPDGFQESPPGVLSLRLSEPLVTSHGMLALKMGNGLS 
                   
               
               
                   
               
               
                 LDDAGNLTSQDVTTVTPPLKKTKTNLSLQTSAPLTVSSGSLTVAAAAPLAVAGTSLTMQSQAPLTVQDAK 
               
               
                   
               
               
                 LGLATQGPLTVSEGKLTLQTSAPLTAADSSTLTVSATPPLSTSNGSLSIDMQAPIYTTNGKLALNIGAPLHV 
               
               
                   
               
               
                 VDTLNALTVVTGQGLTINGRALQTRVTGALSYDTEGNIQLQAGGGMRIDNNGQLILNVAYPFDAQNNLS 
               
               
                   
               
               
                 LRLGQGPLIVNSAHNLDLNLNRGLYLFTSGNTKKLEVNIKTAKGLFYDGTAIAINAGDGLQFGSGSDTNPL 
               
               
                   
               
               
                 QTKLGLGLEYDSNKAIITKLGTGLSFDNTGAITVGNKNDDKLTLWTTPDPSPNCRINSEKDAKLTLVLTKC 
               
               
                   
               
               
                 GSQVLASVSVLSVKGSLAPISGTVTSAQIVLRFDENGVLLSNSSLDPQYWNYRKGDSTEGTAYTNAVGFM 
               
               
                   
               
               
                 PNLTAYPKTQSQTAKSNIVSQVYLNGDKTKPMTLTITLNGTNETGDATVSTYSMSFSWNWNGSNYINDTF 
               
               
                   
               
               
                 QTNSFTFSYIAQE 
               
               
                   
               
               
                 PanAd2 fiber amino acid sequence 
               
               
                 SEQ ID NO: 36 
                   
               
               
                 MKRAKTSDETFNPVYPYDTENGPPSVPFLTPPFVSPDGFQESPPGVLSLRLSEPLVTSHGMLALKMGNGLS 
                   
               
               
                   
               
               
                 LDDAGNLTSQDVTTVTPPLKKTKTNLSLQTSAPLTVSSGSLTVAAAAPLAVAGTSLTMQSQAPLTVQDAK 
               
               
                   
               
               
                 LGLATQGPLTVSEGKLTLQTSAPLTAADSSTLTVSATPPLSTSNGSLSIDMQAPIYTTNGKLALNIGAPLHV 
               
               
                   
               
               
                 VDTLNALTVVTGQGLTINGRALQTRVTGALSYDTEGNIQLQAGGGMRIDNNGQLILNVAYPFDAQNNLS 
               
               
                   
               
               
                 LRLGQGPLIVNSAHNLDLNLNRGLYLFTSGNTKKLEVNIKTAKGLFYDGTAIAINAGDGLQFGSGSDTNPL 
               
               
                   
               
               
                 QTKLGLGLEYDSNKAIITKLGTGLSFDNTGAITVGNKNDDKLTLWTTPDPSPNCRINSEKDAKLTLVLTKC 
               
               
                   
               
               
                 GSQVLASVSVLSVKGSLAPISGTVTSAQIVLRFDENGVLLSNSSLDPQYWNYRKGDSTEGTAYTNAVGFM 
               
               
                   
               
               
                 PNLTAYPKTQSQTAKSNIVSQVYLNGDKTKPMTLTITLNGTNETGDATVSTYSMSFSWNWNGSNYINDTF 
               
               
                   
               
               
                 QTNSFTFSYIAQE 
               
               
                   
               
               
                 RSV FΔTM-N-M2-1 amino acid sequence 
               
               
                 SEQ ID NO: 37 
                   
               
               
                 MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTD 
                   
               
               
                   
               
               
                 AKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLL 
               
               
                   
               
               
                 GVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCS 
               
               
                   
               
               
                 ISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLNDMPITNDQKKLMSNNVQIVRQQSY 
               
               
                   
               
               
                 SIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAET 
               
               
                   
               
               
                 CKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKN 
               
               
                   
               
               
                 RGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKIN 
               
               
                   
               
               
                 QSLAFIRKSDELLHNVNAGKSTTNRKRRAPVKQTLNFDLLKLAGDVESNPGPMALSKVKLNDTLNKDQL 
               
               
                   
               
               
                 LSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGY 
               
               
                   
               
               
                 HVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGM 
               
               
                   
               
               
                 IILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANS 
               
               
                   
               
               
                 FYEVFEKYPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASV 
               
               
                   
               
               
                 QAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDL 
               
               
                   
               
               
                 YDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVELGGGGSGGGGMSRRNPCKNFIRGHC 
               
               
                   
               
               
                 LNGKRCHFSHNYFEWPPHALLVRQNFMLNRILKSMDKSIDTLSEISGAAELDRTEEYALGVVGVLESYIGS 
               
               
                   
               
               
                 INNITKQSACVAMSKLLTELNSDDIKKLRDNEELNSPKIRVYNTVISYIESNRKNNKQTIHLLKRLPADVLK 
               
               
                   
               
               
                 KTIKNTLDIHKSITINNPKESTVSDTNDHAKNNDTT 
               
               
                   
               
               
                 HIV Gag polynucleotide sequence 
               
               
                 SEQ ID NO: 38 
                   
               
               
                 ATGGGTGCTAGGGCTTCTGTGCTGTCTGGTGGTGAGCTGGACAAGTGGGAGAAGATCAGGCTGAGGC 
                   
               
               
                   
               
               
                 CTGGTGGCAAGAAGAAGTACAAGCTAAAGCACATTGTGTGGGCCTCCAGGGAGCTGGAGAGGTTTG 
               
               
                   
               
               
                 CTGTGAACCCTGGCCTGCTGGAGACCTCTGAGGGGTGCAGGCAGATCCTGGGCCAGCTCCAGCCCTC 
               
               
                   
               
               
                 CCTGCAAACAGGCTCTGAGGAGCTGAGGTCCCTGTACAACACAGTGGCTACCCTGTACTGTGTGCAC 
               
               
                   
               
               
                 CAGAAGATTGATGTGAAGGACACCAAGGAGGCCCTGGAGAAGATTGAGGAGGAGCAGAACAAGTCC 
               
               
                   
               
               
                 AAGAAGAAGGCCCAGCAGGCTGCTGCTGGCACAGGCAACTCCAGCCAGGTGTCCCAGAACTACCCC 
               
               
                   
               
               
                 ATTGTGCAGAACCTCCAGGGCCAGATGGTGCACCAGGCCATCTCCCCCCGGACCCTGAATGCCTGGG 
               
               
                   
               
               
                 TGAAGGTGGTGGAGGAGAGGCCTTCTCCCCTGAGGTGATCCCCATGTTCTCTGCCCTGTCTGAGGGTG 
               
               
                   
               
               
                 CCACCCCCCAGGACCTGAACACCATGCTGAACACAGTGGGGGGCCATCAGGCTGCCATGCAGATGCT 
               
               
                   
               
               
                 GAAGGAGACCATCAATGAGGAGGCTGCTGAGTGGGACAGGCTGCATCCTGTGCACGCTGGCCCCATT 
               
               
                   
               
               
                 GCCCCCGGCCAGATGAGGGAGCCCAGGGGCTCTGACATTGCTGGCACCACCTCCACCCTCCAGGAGC 
               
               
                   
               
               
                 AGATTGGCTGGATGACCAACAACCCCCCCATCCCTGTGGGGGAAATCTACAAGAGGTGGATCATCCT 
               
               
                   
               
               
                 GGGCCTGAACAAGATTGTGAGGATGTACTCCCCCACCTCCATCCTGGACATCAGGCAGGGCCCCAAG 
               
               
                   
               
               
                 GAGCCCTTCAGGGACTATGTGGACAGGTTCTACAAGACCCTGAGGGCTGAGCAGGCCTCCCAGGAGG 
               
               
                   
               
               
                 TGAAGAACTGGATGACAGAGACCCTGCTGGTGCAGAATGCCAACCCTGACTGCAAGACCATCCTGAA 
               
               
                   
               
               
                 GGCCCTGGGCCCTGCTGCCACCCTGGAGGAGATGATGACAGCCTGCCAGGGGGTGGGGGGCCCTGGT 
               
               
                   
               
               
                 CACAAGGCCAGGGTGCTGGCTGAGGCCATGTCCCAGGTGACCAACTCCGCCACCATCATGATGCAGA 
               
               
                   
               
               
                 GGGGCAACTTCAGGAACCAGAGGAAGACAGTGAAGTGCTTCAACTGTGGCAAGGTGGGCCACATTG 
               
               
                   
               
               
                 CCAAGAACTGTAGGGCCCCCAGGAAGAAGGGCTGCTGGAAGTGTGGCAAGGAGGGCCACCAGATGA 
               
               
                   
               
               
                 AGGACTGCAATGAGAGGCAGGCCAACTTCCTGGGCAAAATCTGGCCCTCCCACAAGGGCAGGCCTG 
               
               
                   
               
               
                 GCAACTTCCTCCAGTCCAGGCCTGAGCCCACAGCCCCTCCCGAGGAGTCCTTCAGGTTTGGGGAGGA 
               
               
                   
               
               
                 GAAGACCACCCCCAGCCAGAAGCAGGAGCCCATTGACAAGGAGCTGTACCCCCTGGCCTCCCTGAG 
               
               
                   
               
               
                 GTCCCTGTTTGGCAACGACCCCTCCTCCCAGTAA