Patent Publication Number: US-2003224393-A1

Title: Gene for peripheral arterial occlusive disease

Description:
RELATED APPLICATION  
     [0001] This application is a continuation-in-part which claims priority to U.S. application Ser. No. 10/060,902, filed Jan. 30, 2002 (converted to provisional application No. ______). The entire teachings of the above applications are incorporated herein by reference. 
    
    
     
       BACKGROUND OF THE INVENTION  
       [0002] Atherosclerosis is the pathology underlying several of mankind&#39;s most lethal diseases, such as myocardial infarction and peripheral arterial occlusive disease. PAOD shares the risk factors of other atherosclerotic diseases, especially smoking, diabetes, hypertension and hyperlipidemia (Dormandy, J., et al.,  Semin. Vasc. Surg.,  12:123 (1999); Hooi, J. D., et al.,  Br. J. Gen. Pract.  49:49 (1999)). PAOD represents atherosclerosis of the large and medium arteries of the limbs, particularly to the lower extremities and includes the aorta and iliac arteries. It often coexists with coronary artery disease and cerebrovascular disease. Clinically significant lesions may gradually narrow the peripheral arteries leading to pain on walking usually relieved by rest (claudication), ischemic ulcers, gangrene, and sometimes limb amputation. Medical therapy is generally ineffective but operations bypassing or replacing the lesion with artificial or venous grafts improve blood flow distally, at least until they become restenosed (Haustein, K. O.,  Int. J. Clin. Pharmacol. Ther.,  35:266 (1997)).  
       SUMMARY OF THE INVENTION  
       [0003] As described herein, it has been discovered that the gene (hereinafter referred to as “PAOD”) that encodes prostaglandin E receptor 3 (subtype EP3) (known as PTGER3 or EP but also referred to herein as a PAOD1 protein or polypeptide) has been correlated through human linkage studies to peripheral arterial occlusive disease, particularly atherosclerosis of the limbs and lower extremities. The present invention relates to isolated nucleic acid molecules comprising a PAOD1 nucleic acid. In one embodiment, the isolated nucleic acid molecule comprises a nucleotide sequence selected from the group consisting of SEQ ID NO: 1 which may optionally comprise at least one polymorphism as shown in Table 1, and the complement thereof. The invention further relates to a nucleic acid molecule which hybridizes under high stringency conditions to a nucleotide sequence selected from the group consisting of SEQ ID NO: 1 which may optionally comprise at least one polymorphism as shown in Table 1, and the complement thereof. The invention additionally relates to isolated nucleic acid molecules (e.g., cDNA molecules) encoding a PAOD1 polypeptide (e.g., encoding isoforms such as those set forth in SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or another splicing variant of PAOD1 polypeptide which includes a polymorphic site and/or exon 4 or 5). Two new exons have been identified (exons 4 and 5) and are shown in FIGS. 3 and 5A to  5 B. Two new splicing variants (isoforms) are described containing the novel exons, referred to herein as EP 3g  and EP 3h  (see FIGS. 3 and 6A to  6 F).  
       [0004] The invention further provides a method for assaying a sample for the presence of a nucleic acid molecule comprising all or a portion of PAOD1 in a sample, comprising contacting said sample with a second nucleic acid molecule comprising a nucleotide sequence encoding a PAOD1 polypeptide (e.g., SEQ ID NO: 1 or the complement of SEQ ID NO: 1 which may optionally comprise at least one polymorphism as shown in Table 1; a nucleotide sequence encoding an isoform or splicing variant such as those selected from the group consisting of any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, which may optionally comprise at least one polymorphism as shown in Table 1, or another splicing variant of PAOD1 polypeptide which includes a polymorphic site and/or exon 4 or 5), or a fragment or derivative thereof, under conditions appropriate for selective hybridization. The invention additionally provides a method for assaying a sample for the level of expression of a PAOD1 polypeptide, or fragment or derivative thereof, comprising detecting (directly or indirectly) the level of expression of the PAOD1 polypeptide, fragment or derivative thereof.  
       [0005] The invention also relates to a vector comprising an isolated nucleic acid molecule of the invention operatively linked to a regulatory sequence, as well as to a recombinant host cell comprising the vector. The invention also provides a method for preparing a polypeptide encoded by an isolated nucleic acid molecule described herein (an PAOD1 polypeptide), comprising culturing a recombinant host cell of the invention under conditions suitable for expression of said nucleic acid molecule.  
       [0006] The invention further provides an isolated polypeptide encoded by isolated nucleic acid molecules of the invention (e.g., PAOD1 polypeptide), as well as fragments or derivatives thereof. In a particular embodiment, the polypeptide comprises the amino acid sequence of any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, and containing at least one polymorphism described herein. In another embodiment, the polypeptide is another splicing variant of an PAOD1 polypeptide, particularly a splicing variant containing all or a portion of exon 4 and/or exon 5. The invention also relates to an isolated polypeptide comprising an amino acid sequence which is greater than about 90 percent identical to the amino acid sequence of any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36 and containing at least one polymorphism described herein, preferably about 95 percent identical, and even more preferably about 98 percent identical.  
       [0007] The invention also relates to an antibody, or an antigen-binding fragment thereof, which selectively binds to a polypeptide of the invention, as well as to a method for assaying the presence of a polypeptide encoded by an isolated nucleic acid molecule of the invention in a sample, comprising contacting said sample with an antibody which specifically binds to the encoded polypeptide.  
       [0008] The invention further relates to methods of diagnosing a predisposition to peripheral arterial occlusive disease. The methods of diagnosing a predisposition to peripheral arterial occlusive disease in an individual include detecting the presence of an alteration in PAOD1, as well as detecting alterations in expression of an PAOD1 polypeptide, such as the presence of different splicing variants of PAOD1 polypeptides. The alterations in expression can be quantitative, qualitative, or both quantitative and qualitative. The methods of the invention allow the accurate diagnosis of peripheral arterial occlusive disease at or before disease onset, thus reducing or minimizing the debilitating effects of peripheral arterial occlusive disease.  
       [0009] The invention additionally relates to an assay for identifying agents which alter (e.g., enhance or inhibit) the activity or expression of one or more PAOD1 polypeptides. For example, a cell, cellular fraction, or solution containing an PAOD1 polypeptide or a fragment or derivative thereof, can be contacted with an agent to be tested, and the level of PAOD1 polypeptide expression or activity can be assessed. The activity or expression of more than one PAOD1 polypeptides can be assessed concurrently (e.g., the cell, cellular fraction, or solution can contain more than one type of PAOD1 polypeptide, such as different splicing variants, and the levels of the different polypeptides or splicing variants can be assessed).  
       [0010] In another embodiment, the invention relates to assays to identify polypeptides which interact with one or more PAOD1 polypeptides. In a yeast two-hybrid system, for example, a first vector is used which includes a nucleic acid encoding a DNA binding domain and also an PAOD1 polypeptide, splicing variant, or fragment or derivative thereof, and a second vector is used which includes a nucleic acid encoding a transcription activation domain and also a nucleic acid encoding a polypeptide which potentially may interact with the PAOD1 polypeptide, splicing variant, or fragment or derivative thereof (e.g., a PAOD1 polypeptide binding agent or receptor). Incubation of yeast containing both the first vector and the second vector under appropriate conditions allows identification of polypeptides which interact with the PAOD1 polypeptide or fragment or derivative thereof, and thus can be agents which alter the activity of expression of an PAOD1 polypeptide.  
       [0011] Agents that enhance or inhibit PAOD1 polypeptide expression or activity are also included in the current invention, as are methods of altering (enhancing or inhibiting) PAOD1 polypeptide expression or activity by contacting a cell containing PAOD1 and/or polypeptide, or by contacting the PAOD1 polypeptide, with an agent that enhances or inhibits expression or activity of PAOD1 or polypeptide.  
       [0012] Additionally, the invention pertains to pharmaceutical compositions comprising the nucleic acids of the invention, the polypeptides of the invention, and/or the agents that alter activity of PAOD1 polypeptide. The invention further pertains to methods of treating peripheral arterial occlusive disease, by administering PAOD1 therapeutic agents, such as nucleic acids of the invention, polypeptides of the invention, the agents that alter activity of PAOD1 polypeptide, or compositions comprising the nucleic acids, polypeptides, and/or the agents that alter activity of PAOD1 polypeptide. 
     
    
    
     BRIEF DESCRIPTION OF THE DRAWINGS  
     [0013] The foregoing and other objects, features and advantages of the invention will be apparent from the following more particular description of preferred embodiments of the invention, as illustrated in the accompanying drawings.  
     [0014] FIGS.  1 A- 1 C show three families used in the linkage study of PAOD1. Two of the families, A and B, have positive lod scores at the chromosome 1p31 locus, while the cousin pair in family C contributes negatively. Sex indicators have been shuffled for some individuals in the top two generations, and unaffected siblings of patients are not shown, to protect privacy. The darkened squares and circles represent men and women, respectively, affected with PAOD1. The cross-hatched shading represents a PAOD1 patient who also had stroke. The slashed symbols represent deceased individuals.  
     [0015]FIG. 2 shows multipoint allele-sharing lod score of chromosome 1 with extra microsatellite markers within PAOD11. The solid line represents the results of all 272 PAOD1 patients. The dashed line represents the results of defining affecteds as PAOD1 without stroke.  
     [0016]FIG. 3 shows various isoforms of PAOD1, including new isoform EP3g and EP3h. Known variants have been reported. See Schmid A, Thierauch K H, Schleuning W D, Dinter H. Splice variants of the human EP3 receptor for prostaglandin E2 , Eur. J. Biochem.,  15;228(1):23-30, February 1995; Kotani et al.,  Genomics,  40:425-434(1997).  
     [0017]FIGS. 4. 1  to  4 . 83  show the annotated genomic nucleic acid sequence of PAOD1 (SEQ ID NO: 1). The ORF starts at ATG at nts 58,162. For exon, the open reading frame starts at ATG and ends at GT. The 5′UTR is upstream of the ATG. For exons 2 and 3, the GT is an internal splice site used in all isoforms except EP3c. The first nts of the 3′UTR for isoform c are underlined. For exon 4, may have splice sites at either AG or AA. For exon 6, in the a2 isoform of EPa1 and a2, exon 6 is cut at the GT and spliced to a 3′UTR that begins at 2,563 nts; underlined in both cases are the first nts of the 3′UTR. Exon 9 is part of two isoforms called EP3v and EP3vi (Kotani, M. et al.,  Genomics  40:425-434 (1997). See Table 4.  
     [0018]FIGS. 5A to  5 B show the nucleic acid (Exons 1 and 2) sequences of exons 1 through 12 (SEQ ID NOs: 2-14).  
     [0019]FIGS. 6A to  6 F show nucleic acid and amino acid sequences for the PTGER3 isoforms (SEQ ID NOs: 15-36). Exon 2 is indicated by the first underline; both are found in all isoforms and code for most of the protein, i.e., the 359 amino acids that make up the extracellular domain and all 7 trans-membrane spanning helices. Tail-forming exons (indicated in bold) make up the different PTGER3 isoforms. The beginning of the 3′ UTR is indicated by the second underling.  
    
    
     DETAILED DESCRIPTION OF THE INVENTION  
     [0020] Extensive genealogical information for a population with population-based lists of patients has been combined with powerful genome sharing methods to map the first major locus in common peripheral arterial occlusive disease. A genome wide scan on patients, related within 6 meiotic events, diagnosed with peripheral arterial occlusive disease and their unaffected relatives has been completed. Locus PAOD11 on chromosome 1p31 has been identified through linkage studies to be associated with peripheral arterial occlusive disease. This locus does not correspond to known susceptibility loci for peripheral arterial occlusive disease or its risk factors (such as diabetes, hyperlipidemia and hypertension), and represents the first mapping of a gene for common peripheral arterial occlusive disease. Until now there have been no known linkage studies of peripheral arterial occlusive disease in humans showing any connection to this region of the chromosome. Based on the linkage studies conducted, Applicant has discovered a direct relationship between the PAOD1 gene and peripheral arterial occlusive disease. Although the PAOD1 gene (i.e., cDNA but not the genomic sequence) from normal individuals is known, there have been no studies directly investigating PAOD1 and peripheral arterial occlusive disease. Moreover, there have been no variant forms reported that have been associated with peripheral arterial occlusive disease. The full sequence of the PAOD1 gene and splicing variants are shown in the Figures and SEQ ID NO: 1. Additional single nucleotide polymorphisms are reported in Table 1 but may not be shown in SEQ ID NO: 1. It should be understood that the nucleic acids and their gene products embraced by the invention include the nucleotide sequence set forth in SEQ ID NO: 1 and may further comprise at least one polymorphism as shown in Table 1.  
     [0021] Nucleic Acids of the Invention  
     [0022] Nucleic Acids, Portions and Variants  
     [0023] Accordingly, the invention pertains to an isolated nucleic acid molecules comprising human PAOD1 nucleic acids having at least one nucleotide alteration and correlated with incidence of peripheral arterial occlusive disease. The term, “PAOD1 or variant PAOD1,” as used herein, refers to an isolated nucleic acid molecule on chromosome 1p31 that is associated with a susceptibility to a number of peripheral arterial occlusive disease phenotypes, and also to a portion or fragment of the isolated nucleic acid molecule (e.g., cDNA or the gene) that encodes PAOD1 polypeptide (e.g., the polypeptide having any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, as shown in the Figures and optionally comprising at least one SNP as set forth in Table 1, or another splicing variant of a PAOD1 polypeptide). In a preferred embodiment, the isolated nucleic acid molecule comprises SEQ ID NO: 1 (shown in FIG. 4) or the complement thereof. In another embodiment, the isolated nucleic acid molecule comprises the sequence of SEQ ID NO: 1 or the complement of SEQ ID NO: 1, except that one or more single nucleotide polymorphisms as shown in Table 1 are also present. In another embodiment, the isolated nucleic acid molecules comprises exon 4 or 5, or both exon 4 and 5.  
     [0024] The isolated nucleic acid molecules of the present invention can be RNA, for example, mRNA, or DNA, such as cDNA and genomic DNA. DNA molecules can be double-stranded or single-stranded; single stranded RNA or DNA can be either the coding, or sense, strand or the non-coding, or antisense, strand. The nucleic acid molecule can include all or a portion of the coding sequence of the gene and can further comprise additional non-coding sequences such as introns and non-coding 3′ and 5′ sequences (including regulatory sequences, for example). Additionally, the nucleic acid molecule can be fused to a marker sequence, for example, a sequence that encodes a polypeptide to assist in isolation or purification of the polypeptide. Such sequences include, but are not limited to, those which encode a glutathione-S-transferase (GST) fusion protein and those which encode a hemagglutinin A (HA) polypeptide marker from influenza.  
     [0025] An “isolated” nucleic acid molecule, as used herein, is one that is separated from nucleic acids which normally flank the gene or nucleotide sequence (as in genomic sequences) and/or has been completely or partially purified from other transcribed sequences (e.g., as in an RNA library). For example, an isolated nucleic acid of the invention may be substantially isolated with respect to the complex cellular milieu in which it naturally occurs, or culture medium when produced by recombinant techniques, or chemical precursors or other chemicals when chemically synthesized. In some instances, the isolated material will form part of a composition (for example, a crude extract containing other substances), buffer system or reagent mix. In other circumstances, the material may be purified to essential homogeneity, for example as determined by PAGE or column chromatography such as HPLC. Preferably, an isolated nucleic acid molecule comprises at least about 50, 80 or 90% (on a molar basis) of all macromolecular species present. With regard to genomic DNA, the term “isolated” also can refer to nucleic acid molecules which are separated from the chromosome with which the genomic DNA is naturally associated. For example, the isolated nucleic acid molecule can contain less than about 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb or 0.1 kb of nucleotides which flank the nucleic acid molecule in the genomic DNA of the cell from which the nucleic acid molecule is derived.  
     [0026] The nucleic acid molecule can be fused to other coding or regulatory sequences and still be considered isolated. Thus, recombinant DNA contained in a vector is included in the definition of “isolated” as used herein. Also, isolated nucleic acid molecules include recombinant DNA molecules in heterologous host cells, as well as partially or substantially purified DNA molecules in solution. “Isolated” nucleic acid molecules also encompass in vivo and in vitro RNA transcripts of the DNA molecules of the present invention. An isolated nucleic acid molecule or nucleotide sequence can include a nucleic acid molecule or nucleotide sequence which is synthesized chemically or by recombinant means. Therefore, recombinant DNA contained in a vector are included in the definition of “isolated” as used herein. Also, isolated nucleotide sequences include recombinant DNA molecules in heterologous organisms, as well as partially or substantially purified DNA molecules in solution. In vivo and in vitro RNA transcripts of the DNA molecules of the present invention are also encompassed by “isolated” nucleotide sequences. Such isolated nucleotide sequences are useful in the manufacture of the encoded polypeptide, as probes for isolating homologous sequences (e.g., from other mammalian species), for gene mapping (e.g., by in situ hybridization with chromosomes), or for detecting expression of the gene in tissue (e.g., human tissue), such as by Northern blot analysis.  
     [0027] The present invention also pertains to variant nucleic acid molecules which are not necessarily found in nature but which encode a PAOD1 polypeptide (e.g., a polypeptide having the amino acid sequence of any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36 or another isoform or splicing variant of PAOD1 polypeptide or polymorphic variant thereof). Thus, for example, DNA molecules which comprise a sequence that is different from the naturally-occurring nucleotide sequence but which, due to the degeneracy of the genetic code, encode a PAOD1 polypeptide of the present invention are also the subject of this invention. The invention also encompasses nucleotide sequences encoding portions (fragments), or encoding variant polypeptides such as analogues or derivatives of the PAOD1 polypeptide. Such variants can be naturally-occurring, such as in the case of allelic variation or single nucleotide polymorphisms, or non-naturally-occurring, such as those induced by various mutagens and mutagenic processes. Intended variations include, but are not limited to, addition, deletion and substitution of one or more nucleotides which can result in conservative or non-conservative amino acid changes, including additions and deletions. Preferably the nucleotide (and/or resultant amino acid) changes are silent or conserved; that is, they do not alter the characteristics or activity of the PAOD1 polypeptide. In one preferred embodiment, the nucleotide sequences are fragments that comprise one or more polymorphic microsatellite markers. In another preferred embodiment, the nucleotide sequences are fragments that comprise one or more single nucleotide polymorphisms in the PAOD1 gene.  
     [0028] Other alterations of the nucleic acid molecules of the invention can include, for example, labeling, methylation, internucleotide modifications such as uncharged linkages (e.g., methyl phosphonates, phosphotriesters, phosphoamidates, carbamates), charged linkages (e.g., phosphorothioates, phosphorodithioates), pendent moieties (e.g., polypeptides), intercalators (e.g., acridine, psoralen), chelators, alkylators, and modified linkages (e.g., alpha anomeric nucleic acids). Also included are synthetic molecules that mimic nucleic acid molecules in the ability to bind to a designated sequences via hydrogen bonding and other chemical interactions. Such molecules include, for example, those in which peptide linkages substitute for phosphate linkages in the backbone of the molecule.  
     [0029] The invention also pertains to nucleic acid molecules which hybridize under high stringency hybridization conditions, such as for selective hybridization, to a nucleotide sequence described herein (e.g., nucleic acid molecules which specifically hybridize to a nucleotide sequence encoding polypeptides described herein, and, optionally, have an activity of the polypeptide). In one embodiment, the invention includes variants described herein which hybridize under high stringency hybridization conditions (e.g., for selective hybridization) to a nucleotide sequence comprising a nucleotide sequence selected from SEQ ID NO: 1 which may optionally comprise at least one polymorphism as shown in Table 1 or the complement thereof. In another embodiment, the invention includes variants described herein which hybridize under high stringency hybridization conditions (e.g., for selective hybridization) to a nucleotide sequence encoding an amino acid sequence selected from any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or other polymorphic variant thereof. In a preferred embodiment, the variant which hybridizes under high stringency hybridizations has an activity of PAOD1.  
     [0030] Such nucleic acid molecules can be detected and/or isolated by specific hybridization (e.g., under high stringency conditions). “Specific hybridization,” as used herein, refers to the ability of a first nucleic acid to hybridize to a second nucleic acid in a manner such that the first nucleic acid does not hybridize to any nucleic acid other than to the second nucleic acid (e.g., when the first nucleic acid has a higher similarity to the second nucleic acid than to any other nucleic acid in a sample wherein the hybridization is to-be performed). “Stringency conditions” for hybridization is a term of art which refers to the incubation and wash conditions, e.g., conditions of temperature and buffer concentration, which permit hybridization of a particular nucleic acid to a second nucleic acid; the first nucleic acid may be perfectly (i.e., 100%) complementary to the second, or the first and second may share some degree of complementarity which is less than perfect (e.g., 70%, 75%, 85%, 90%, 95%, 98%). For example, certain high stringency conditions can be used which distinguish perfectly complementary nucleic acids from those of less complementarity. “High stringency conditions”, “moderate stringency conditions” and “low stringency conditions” for nucleic acid hybridizations are explained on pages 2.10.1-2.10.16 and pages 6.3.1-6.3.6 in  Current Protocols in Molecular Biology  (Ausubel, F. M. et al., “ Current Protocols in Molecular Biology ”, John Wiley &amp; Sons, (1998), the entire teachings of which are incorporated by reference herein). The exact conditions which determine the stringency of hybridization depend not only on ionic strength (e.g., 0.2×SSC, 0.1×SSC), temperature (e.g., room temperature, 42° C., 68° C.) and the concentration of destabilizing agents such as formamide or denaturing agents such as SDS, but also on factors such as the length of the nucleic acid sequence, base composition, percent mismatch between hybridizing sequences and the frequency of occurrence of subsets of that sequence within other non-identical sequences. Thus, equivalent conditions can be determined by varying one or more of these parameters while maintaining a similar degree of identity or similarity between the two nucleic acid molecules. Typically, conditions are used such that sequences at least about 60%, at least about 70%, at least about 80%, at least about 90% or at least about 95% or more identical to each other remain hybridized to one another. By varying hybridization conditions from a level of stringency at which no hybridization occurs to a level at which hybridization is first observed, conditions which will allow a given sequence to hybridize (e.g., selectively) with the most similar sequences in the sample can be determined.  
     [0031] Exemplary conditions are described in Krause, M. H. and S. A. Aaronson,  Methods in Enzymology,  200:546-556 (1991). Also, in, Ausubel, et al., “ Current Protocols in Molecular Biology ”, John Wiley &amp; Sons, (1998), which describes the determination of washing conditions for moderate or low stringency conditions. Washing is the step in which conditions are usually set so as to determine a minimum level of complementarity of the hybrids. Generally, starting from the lowest temperature at which only homologous hybridization occurs, each ° C. by which the final wash temperature is reduced (holding SSC concentration constant) allows an increase by 1% in the maximum extent of mismatching among the sequences that hybridize. Generally, doubling the concentration of SSC results in an increase in T m  of ˜17° C. Using these guidelines, the washing temperature can be determined empirically for high, moderate or low stringency, depending on the level of mismatch sought.  
     [0032] For example, a low stringency wash can comprise washing in a solution containing 0.2×SSC/0.1% SDS for 10 min at room temperature; a moderate stringency wash can comprise washing in a prewarmed solution (42° C.) solution containing 0.2×SSC/0.1% SDS for 15 min at 42° C.; and a high stringency wash can comprise washing in prewarmed (68° C.) solution containing 0.1×SSC/0.1%SDS for 15 min at 68° C. Furthermore, washes can be performed repeatedly or sequentially to obtain a desired result as known in the art. Equivalent conditions can be determined by varying one or more of the parameters given as an example, as known in the art, while maintaining a similar degree of identity or similarity between the target nucleic acid molecule and the primer or probe used.  
     [0033] The percent homology or identity of two nucleotide or amino acid sequences can be determined by aligning the sequences for optimal comparison purposes (e.g., gaps can be introduced in the sequence of a first sequence for optimal alignment). The nucleotides or amino acids at corresponding positions are then compared, and the percent identity between the two sequences is a function of the number of identical positions shared by the sequences (i.e., % identity=# of identical positions/total # of positions×100). When a position in one sequence is occupied by the same nucleotide or amino acid residue as the corresponding position in the other sequence, then the molecules are homologous at that position. As used herein, nucleic acid or amino acid “homology” is equivalent to nucleic acid or amino acid “identity”. In certain embodiments, the length of a sequence aligned for comparison purposes is at least 30%, for example, at least 40%, in certain embodiments at least 60%, and in other embodiments at least 70%, 80%, 90% or 95% of the length of the reference sequence. The actual comparison of the two sequences can be accomplished by well-known methods, for example, using a mathematical algorithm. A preferred, non-limiting example of such a mathematical algorithm is described in Karlin et al.,  Proc. Natl. Acad. Sci. USA  90:5873-5877 (1993). Such an algorithm is incorporated into the NBLAST and XBLAST programs (version 2.0) as described in Altschul et al.,  Nucleic Acids Res.  25:389-3402 (1997). When utilizing BLAST and Gapped BLAST programs, the default parameters of the respective programs (e.g., NBLAST) can be used. In one embodiment, parameters for sequence comparison can be set at score=100, wordlength=12, or can be varied (e.g., W=5 or W=20).  
     [0034] Another preferred, non-limiting example of a mathematical algorithm utilized for the comparison of sequences is the algorithm of Myers and Miller, CABIOS (1989). Such an algorithm is incorporated into the ALIGN program (version 2.0) which is part of the GCG-sequence alignment software package (Acceirys, Cambridge, UK). When utilizing the ALIGN program for comparing amino acid sequences, a PAM120 weight residue table, a gap length penalty of 12, and a gap penalty of 4 can be used. Additional algorithms for sequence analysis are known in the art and include ADVANCE and ADAM as described in Torellis and Robotti (1994)  Comput. Appl. Biosci.,  10:3-5; and FASTA described in Pearson and Lipman (1988)  PNAS,  85:2444-8.  
     [0035] In another embodiment, the percent identity between two amino acid sequences can be accomplished using the GAP program in the GCG-software package using either a Blossom 63 matrix or a PAM250 matrix, and a gap weight of 12, 10, 8, 6, or 4 and a length weight of 2, 3, or 4. In yet another embodiment, the percent identity between two nucleic acid sequences can be accomplished using the GAP program in the GCG-software package, using a gap weight of 50 and a length weight of 3.  
     [0036] The present invention also provides isolated nucleic acid molecules that contain a fragment or portion that hybridizes under highly stringent conditions to a nucleotide sequence comprising a nucleotide sequence selected from SEQ ID NO: 1 which may optionally comprise at least one polymorphism as shown in Table 1 and the complement thereof, and also provides isolated nucleic acid molecules that contain a fragment or portion that hybridizes under highly stringent conditions to a nucleotide sequence encoding an amino acid sequence selected from any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or polymorphic variant thereof. The nucleic acid fragments of the invention are at least about 15, preferably at least about 18, 20, 23 or 25 nucleotides, and can be 30, 40, 50, 100, 200 or more nucleotides in length. Longer fragments, for example, 30 or more nucleotides in length, which encode antigenic polypeptides described herein are particularly useful, such as for the generation of antibodies as described below.  
     [0037] Probes and Primers  
     [0038] In a related aspect, the nucleic acid fragments of the invention are used as probes or primers in assays such as those described herein. “Probes” or “primers” are oligonucleotides that hybridize in a base-specific manner to a complementary strand of nucleic acid molecules. Such probes and primers include polypeptide nucleic acids, as described in Nielsen et al.,  Science,  254, 1497-1500 (1991).  
     [0039] A probe or primer comprises a region of nucleotide sequence that hybridizes to at least about 15, for example about 20-25, and in certain embodiments about 40, 50 or 75, consecutive nucleotides of a nucleic acid molecule comprising a contiguous nucleotide sequence or polymorphic variant thereof. In other embodiments, a probe or primer comprises 100 or fewer nucleotides, in certain embodiments from 6 to 50 nucleotides, for example from 12 to 30 nucleotides. In other embodiments, the probe or primer is at least 70% identical to the contiguous nucleotide sequence or to the complement of the contiguous nucleotide sequence, for example at least 80% identical, in certain embodiments at least 90% identical, and in other embodiments at least 95% identical, or even capable of selectively hybridizing to the contiguous nucleotide sequence or to the complement of the contiguous nucleotide sequence. Often, the probe or primer further comprises a label, e.g., radioisotope, fluorescent compound, enzyme, or enzyme co-factor.  
     [0040] The nucleic acid molecules of the invention such as those described above can be identified and isolated using standard molecular biology techniques and the sequence information provided herein. For example, nucleic acid molecules can be amplified and isolated by the polymerase chain reaction using synthetic oligonucleotide primers designed based on one or more of the sequences provided in SEQ ID NO: 1 which may optionally comprise at least one polymorphism shown in Table 1, and/or the complement thereof, or designed based on nucleotides based on sequences encoding one or more of the amino acid sequences provided herein. See generally  PCR Technology: Principles and Applications for DNA Amplification  (ed. H. A. Erlich, Freeman Press, NY, N.Y., 1992);  PCR Protocols. A Guide to Methods and Applications  (Eds. Innis, et al., Academic Press, San Diego, Calif., 1990); Mattila et al.,  Nucleic Acids Res.,  19:4967 (1991); Eckert et al.,  PCR Methods and Applications,  1:17 (1991); PCR (eds. McPherson et al., IRL Press, Oxford); and U.S. Pat. No. 4,683,202. The nucleic acid molecules can be amplified using cDNA, mRNA or genomic DNA as a template, cloned into an appropriate vector and characterized by DNA sequence analysis.  
     [0041] Other suitable amplification methods include the ligase chain reaction (LCR) (see Wu and Wallace,  Genomics,  4:560 (1989), Landegren et al.,  Science,  241:1077 (1988), transcription amplification (Kwoh et al,  Proc. Natl. Acad. Sci. USA,  86:1173 (1989)), and self-sustained sequence replication (Guatelli et al.,  Proc. Nat. Acad. Sci. USA,  87:1874 (1990)) and nucleic acid based sequence amplification (NASBA). The latter two amplification methods involve isothermal reactions based on isothermal transcription, which produce both single stranded RNA (ssRNA) and double stranded DNA (dsDNA) as the amplification products in a ratio of about 30 or 100 to 1, respectively.  
     [0042] The amplified DNA can be labelled, for example radiolabelled, and used as a probe for screening a cDNA library derived from human cells, mRNA in zap express, ZIPLOX or other suitable vector. Corresponding clones can be isolated, DNA can obtained following in vivo excision, and the cloned insert can be sequenced in either or both orientations by art recognized methods to identify the correct reading frame encoding a polypeptide of the appropriate molecular weight. For example, the direct analysis of the nucleotide sequence of nucleic acid molecules of the present invention can be accomplished using well-known methods that are commercially available. See, for example, Sambrook et al.,  Molecular Cloning, A Laboratory Manual  (2nd Ed., CSHP, New York 1989); Zyskind et al., Recombinant DNA Laboratory Manual, (Acad. Press, 1988)). Using these or similar methods, the polypeptide and the DNA encoding the polypeptide can be isolated, sequenced and further characterized.  
     [0043] Antisense nucleic acid molecules of the invention can be designed using the nucleotide sequences of SEQ ID NO: 1 and/or the complement of SEQ ID NO: 1, and/or a portion of SEQ ID NO: 1 or the complement of SEQ ID NO: 1 and/or a sequence encoding the amino acid sequences or any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or encoding a portion of any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, (wherein any one of these may optionally comprise at least one polymorphism as shown in Table 1) and constructed using chemical synthesis and enzymatic ligation reactions using procedures known in the art. For example, an antisense nucleic acid molecule (e.g., an antisense oligonucleotide) can be chemically synthesized using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used. Alternatively, the antisense nucleic acid molecule can be produced biologically using an expression vector into which a nucleic acid molecule has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid molecule will be of an antisense orientation to a target nucleic acid of interest).  
     [0044] In general, the isolated nucleic acid sequences of the invention can be used as molecular weight markers on Southern gels, and as chromosome markers which are labeled to map related gene positions. The nucleic acid sequences can also be used to compare with endogenous DNA sequences in patients to identify genetic disorders (e.g., a predisposition for or susceptibility to peripheral arterial occlusive disease), and as probes, such as to hybridize and discover related DNA sequences or to subtract out known sequences from a sample. The nucleic acid sequences can further be used to derive primers for genetic fingerprinting, to raise anti-polypeptide antibodies using DNA immunization techniques, and as an antigen to raise anti-DNA antibodies or elicit immune responses. Portions or fragments of the nucleotide sequences identified herein (and the corresponding complete gene sequences) can be used in numerous ways as polynucleotide reagents. For example, these sequences can be used to: (i) map their respective genes on a chromosome; and, thus, locate gene regions associated with genetic disease; (ii) identify an individual from a minute biological sample (tissue typing); and (iii) aid in forensic identification of a biological sample. Additionally, the nucleotide sequences of the invention can be used to identify and express recombinant polypeptides for analysis, characterization or therapeutic use, or as markers for tissues in which the corresponding polypeptide is expressed, either constitutively, during tissue differentiation, or in diseased states. The nucleic acid sequences can additionally be used as reagents in the screening and/or diagnostic assays described herein, and can also be included as components of kits (e.g., reagent kits) for use in the screening and/or diagnostic assays described herein.  
     [0045] Vectors  
     [0046] Another aspect of the invention pertains to nucleic acid constructs containing a nucleic acid molecule selected from the group consisting of SEQ ID NO: 1 which may optionally comprise at least one polymorphism shown in Table 1 and the complement thereof (or a portion thereof). Yet another aspect of the invention pertains to nucleic acid constructs containing a nucleic acid molecule encoding the amino acid sequence of any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or polymorphic variant thereof. The constructs comprise a vector (e.g., an expression vector) into which a sequence of the invention has been inserted in a sense or antisense orientation. As used herein, the term “vector” refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked. One type of vector is a “plasmid”, which refers to a circular double stranded DNA loop into which additional DNA segments can be ligated. Another type of vector is a viral vector, wherein additional DNA segments can be ligated into the viral genome. Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g., bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) are integrated into the genome of a host cell upon introduction into the host cell, and thereby are replicated along with the host genome. Moreover, certain vectors, expression vectors, are capable of directing the expression of genes to which they are operably linked. In general, expression vectors of utility in recombinant DNA techniques are often in the form of plasmids. However, the invention is intended to include such other forms of expression vectors, such as viral vectors (e.g., replication defective retroviruses, adenoviruses and adeno-associated viruses) that serve equivalent functions.  
     [0047] Preferred recombinant expression vectors of the invention comprise a nucleic acid molecule of the invention in a form suitable for expression of the nucleic acid molecule in a host cell. This means that the recombinant expression vectors include one or more regulatory sequences, selected on the basis of the host cells to be used for expression, which is operably linked to the nucleic acid sequence to be expressed. Within a recombinant expression vector, “operably or operatively linked” is intended to mean that the nucleotide sequence of interest is linked to the regulatory sequence(s) in a manner which allows for expression of the nucleotide sequence (e.g., in an in vitro transcription/translation system or in a host cell when the vector is introduced into the host cell). The term “regulatory sequence” is intended to include promoters, enhancers and other expression control elements (e.g., polyadenylation signals). Such regulatory sequences are described, for example, in Goeddel,  Gene Expression Technology: Methods in Enzymology  185, Academic Press, San Diego, Calif. (1990). Regulatory sequences include those which direct constitutive expression of a nucleotide sequence in many types of host cell and those which direct expression of the nucleotide sequence only in certain host cells (e.g., tissue-specific regulatory sequences). It will be appreciated by those skilled in the art that the design of the expression vector can depend on such factors as the choice of the host cell to be transformed and the level of expression of polypeptide desired. The expression vectors of the invention can be introduced into host cells to thereby produce polypeptides, including fusion polypeptides, encoded by nucleic acid molecules as described herein.  
     [0048] The recombinant expression vectors of the invention can be designed for expression of a polypeptide of the invention in prokaryotic or eukaryotic cells, e.g., bacterial cells such as  E. coli , insect cells (using baculovirus expression vectors), yeast cells or mammalian cells. Suitable host cells are discussed further in Goeddel, supra. Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example using T7 promoter regulatory sequences and T7 polymerase.  
     [0049] Another aspect of the invention pertains to host cells into which a recombinant expression vector of the invention has been introduced. The terms “host cell” and “recombinant host cell” are used interchangeably herein. It is understood that such terms refer not only to the particular subject cell but also to the progeny or potential progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but are still included within the scope of the term as used herein.  
     [0050] A host cell can be any prokaryotic or eukaryotic cell. For example, a nucleic acid molecule of the invention can be expressed in bacterial cells (e.g.,  E. coli ), insect cells, yeast or mammalian cells (such as Chinese hamster ovary cells (CHO) or COS cells). Other suitable host cells are known to those skilled in the art.  
     [0051] Vector DNA can be introduced into prokaryotic or eukaryotic cells via conventional transformation or transfection techniques. As used herein, the terms “transformation” and “transfection” are intended to refer to a variety of art-recognized techniques for introducing a foreign nucleic acid molecule (e.g., DNA) into a host cell, including calcium phosphate or calcium chloride co-precipitation, DEAE-dextran-mediated transfection, lipofection, or electroporation. Suitable methods for transforming or transfecting host cells can be found in Sambrook, et al. (supra), and other laboratory manuals.  
     [0052] For stable transfection of mammalian cells, it is known that, depending upon the expression vector and transfection technique used, only a small fraction of cells may integrate the foreign DNA into their genome. In order to identify and select these integrants, a gene that encodes a selectable marker (e.g., for resistance to antibiotics) is generally introduced into the host cells along with the gene of interest. Preferred selectable markers include those that confer resistance to drugs, such as G418, hygromycin and methotrexate. Nucleic acid molecules encoding a selectable marker can be introduced into a host cell on the same vector as the nucleic acid molecule of the invention or can be introduced on a separate vector. Cells stably transfected with the introduced nucleic acid molecule can be identified by drug selection (e.g., cells that have incorporated the selectable marker gene will survive, while the other cells die).  
     [0053] A host cell of the invention, such as a prokaryotic or eukaryotic host cell in culture, can be used to produce (i.e., express) a polypeptide of the invention. Accordingly, the invention further provides methods for producing a polypeptide using the host cells of the invention. In one embodiment, the method comprises culturing the host cell of invention (into which a recombinant expression vector encoding a polypeptide of the invention has been introduced) in a suitable medium such that the polypeptide is produced. In another embodiment, the method further comprises isolating the polypeptide from the medium or the host cell.  
     [0054] The host cells of the invention can also be used to produce nonhuman transgenic animals. For example, in one embodiment, a host cell of the invention is a fertilized oocyte or an embryonic stem cell into which a nucleic acid molecule of the invention has been introduced (e.g., an exogenous PAOD1 gene, or an exogenous nucleic acid encoding PAOD1 polypeptide). Such host cells can then be used to create non-human transgenic animals in which exogenous nucleotide sequences have been introduced into the genome or homologous recombinant animals in which endogenous nucleotide sequences have been altered. Such animals are useful for studying the function and/or activity of the nucleotide sequence and polypeptide encoded by the sequence and for identifying and/or evaluating modulators of their activity. As used herein, a “transgenic animal” is a non-human animal, preferably a mammal, more preferably a rodent such as a rat or mouse, in which one or more of the cells of the animal includes a transgene. Other examples of transgenic animals include non-human primates, sheep, dogs, cows, goats, chickens and amphibians. A transgene is exogenous DNA which is integrated into the genome of a cell from which a transgenic animal develops and which remains in the genome of the mature animal, thereby directing the expression of an encoded gene product in one or more cell types or tissues of the transgenic animal. As used herein, an “homologous recombinant animal” is a non-human animal, preferably a mammal, more preferably a mouse, in which an endogenous gene has been altered by homologous recombination between the endogenous gene and an exogenous DNA molecule introduced into a cell of the animal, e.g., an embryonic cell of the animal, prior to development of the animal.  
     [0055] Methods for generating transgenic animals via embryo manipulation and microinjection, particularly animals such as mice, have become conventional in the art and are described, for example, in U.S. Pat. Nos. 4,736,866 and 4,870,009, U.S. Pat. No. 4,873,191 and in Hogan,  Manipulating the Mouse Embryo  (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1986). Methods for constructing homologous recombination vectors and homologous recombinant animals are described further in Bradley (1991)  Current Opinion in Bio/Technology,  2:823-829 and in PCT Publication Nos. WO 90/11354, WO 91/01140, WO 92/0968, and WO 93/04169. Clones of the non-human transgenic animals described herein can also be produced according to the methods described in Wilmut et al. (1997)  Nature,  385:810-813 and PCT Publication Nos. WO 97/07668 and WO 97/07669.  
     [0056] Polypeptides of the Invention  
     [0057] The present invention also pertains to isolated polypeptides encoded by PAOD1 (“PAOD1 polypeptides”) and fragments and variants thereof, as well as polypeptides encoded by nucleotide sequences described herein (e.g., other splicing variants). The term “polypeptide” refers to a polymer of amino acids, and not to a specific length; thus, peptides, oligopeptides and proteins are included within the definition of a polypeptide. As used herein, a polypeptide is said to be “isolated” or “purified” when it is substantially free of cellular material when it is isolated from recombinant and non-recombinant cells, or free of chemical precursors or other chemicals when it is chemically synthesized. A polypeptide, however, can be joined to another polypeptide with which it is not normally associated in a cell (e.g., in a “fusion protein”) and still be “isolated” or “purified.” 
     [0058] The polypeptides of the invention can be purified to homogeneity. It is understood, however, that preparations in which the polypeptide is not purified to homogeneity are useful. The critical feature is that the preparation allows for the desired function of the polypeptide, even in the presence of considerable amounts of other components. Thus, the invention encompasses various degrees of purity. In one embodiment, the language “substantially free of cellular material” includes preparations of the polypeptide having less than about 30% (by dry weight) other proteins (i.e., contaminating protein), less than about 20% other proteins, less than about 10% other proteins, or less than about 5% other proteins.  
     [0059] When a polypeptide is recombinantly produced, it can also be substantially free of culture medium, i.e., culture medium represents less than about 20%, less than about 10%, or less than about 5% of the volume of the polypeptide preparation. The language “substantially free of chemical precursors or other chemicals” includes preparations of the polypeptide in which it is separated from chemical precursors or other chemicals that are involved in its synthesis. In one embodiment, the language “substantially free of chemical precursors or other chemicals” includes preparations of the polypeptide having less than about 30% (by dry weight) chemical precursors or other chemicals, less than about 20% chemical precursors or other chemicals, less than about 10% chemical precursors or other chemicals, or less than about 5% chemical precursors or other chemicals.  
     [0060] In one embodiment, a polypeptide of the invention comprises an amino acid sequence encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1 which may optionally comprise at least one polymorphism shown in Table 1 and complements and portions thereof, e.g., any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36 or a portion or polymorphic variant thereof. However, the polypeptides of the invention also encompass fragment and sequence variants. Variants include a substantially homologous polypeptide encoded by the same genetic locus in an organism, i.e., an allelic variant, as well as other splicing variants. Variants also encompass polypeptides derived from other genetic loci in an organism, but having substantial homology to a polypeptide encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1 which may optionally comprise at least one polymorphism shown in Table 1 and complements and portions thereof, or having substantial homology to a polypeptide encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of nucleotide sequences encoding any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or polymorphic variants thereof. Variants also include polypeptides substantially homologous or identical to these polypeptides but derived from another organism, i.e., an ortholog. Variants also include polypeptides that are substantially homologous or identical to these polypeptides that are produced by chemical synthesis. Variants also include polypeptides that are substantially homologous or identical to these polypeptides that are produced by recombinant methods.  
     [0061] As used herein, two polypeptides (or a region of the polypeptides) are substantially homologous or identical when the amino acid sequences are at least about 45-55%, in certain embodiments at least about 70-75%, in other embodiments at least about 80-85%, and in other embodiments greater than about 90% or more homologous or identical. A substantially homologous amino acid sequence, according to the present invention, will be encoded by a nucleic acid molecule hybridizing to SEQ ID NO: 1 which may optionally comprise at least one polymorphism shown in Table 1, or portion thereof, under stringent conditions as more particularly described above, or will be encoded by a nucleic acid molecule hybridizing to a nucleic acid sequence encoding any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, portion thereof or polymorphic variant thereof, under stringent conditions as more particularly described thereof.  
     [0062] The invention also encompasses polypeptides having a lower degree of identity but having sufficient similarity so as to perform one or more of the same functions performed by a polypeptide encoded by a nucleic acid molecule of the invention. Similarity is determined by conserved amino acid substitution. Such substitutions are those that substitute a given amino acid in a polypeptide by another amino acid of like characteristics. Conservative substitutions are likely to be phenotypically silent. Typically seen as conservative substitutions are the replacements, one for another, among the aliphatic amino acids Ala, Val, Leu and Ile; interchange of the hydroxyl residues Ser and Thr, exchange of the acidic residues Asp and Glu, substitution between the amide residues Asn and Gln, exchange of the basic residues Lys and Arg and replacements among the aromatic residues Phe and Tyr. Guidance concerning which amino acid changes are likely to be phenotypically silent are found in Bowie et al.,  Science  247:1306-1310 (1990).  
     [0063] A variant polypeptide can differ in amino acid sequence by one or more substitutions, deletions, insertions, inversions, fusions, and truncations or a combination of any of these. Further, variant polypeptides can be fully functional or can lack function in one or more activities. Fully functional variants typically contain only conservative variation or variation in non-critical residues or in non-critical regions. Functional variants can also contain substitution of similar amino acids that result in no change or an insignificant change in function. Alternatively, such substitutions may positively or negatively affect function to some degree. Non-functional variants typically contain one or more non-conservative amino acid substitutions, deletions, insertions, inversions, or truncation or a substitution, insertion, inversion, or deletion in a critical residue or critical region.  
     [0064] Amino acids that are essential for function can be identified by methods known in the art, such as site-directed mutagenesis or alanine-scanning mutagenesis (Cunningham et al.,  Science,  244:1081-1085 (1989)). The latter procedure introduces single alanine mutations at every residue in the molecule. The resulting mutant molecules are then tested for biological activity in vitro, or in vitro proliferative activity. Sites that are critical for polypeptide activity can also be determined by structural analysis such as crystallization, nuclear magnetic resonance or photoaffinity labeling (Smith et al.,  J. Mol. Biol.,  224:899-904 (1992); de Vos et al.,  Science,  255:306-312 (1992)).  
     [0065] The invention also includes polypeptide fragments of the polypeptides of the invention. Fragments can be derived from a polypeptide encoded by a nucleic acid molecule comprising SEQ ID NO: 1 which may optionally comprise at least one polymorphism shown in Table 1 or a portion thereof and the complements thereof (e.g., any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or other splicing variants). However, the invention also encompasses fragments of the variants of the polypeptides described herein. As used herein, a fragment comprises at least 6 contiguous amino acids. Useful fragments include those that retain one or more of the biological activities of the polypeptide as well as fragments that can be used as an immunogen to generate polypeptide-specific antibodies.  
     [0066] Biologically active fragments (peptides which are, for example, 6, 9, 12, 15, 16, 20, 30, 35, 36, 37, 38, 39, 40, 50, 100 or more amino acids in length) can comprise a domain, segment, or motif that has been identified by analysis of the polypeptide sequence using well-known methods, e.g., signal peptides, extracellular domains, one or more transmembrane segments or loops, ligand binding regions, zinc finger domains, DNA binding domains, acylation sites, glycosylation sites, or phosphorylation sites.  
     [0067] Fragments can be discrete (not fused to other amino acids or polypeptides) or can be within a larger polypeptide. Further, several fragments can be comprised within a single larger polypeptide. In one embodiment a fragment designed for expression in a host can have heterologous pre- and pro-polypeptide regions fused to the amino terminus of the polypeptide fragment and an additional region fused to the carboxyl terminus of the fragment.  
     [0068] The invention thus provides chimeric or fusion polypeptides. These comprise a polypeptide of the invention operatively linked to a heterologous protein or polypeptide having an amino acid sequence not substantially homologous to the polypeptide. “Operatively linked” indicates that the polypeptide and the heterologous protein are fused in-frame. The heterologous protein can be fused to the N-terminus or C-terminus of the polypeptide. In one embodiment the fusion polypeptide does not affect function of the polypeptide per se. For example, the fusion polypeptide can be a GST-fusion polypeptide in which the polypeptide sequences are fused to the C-terminus of the GST sequences. Other types of fusion polypeptides include, but are not limited to, enzymatic fusion polypeptides, for example β-galactosidase fusions, yeast two-hybrid GAL fusions, poly-His fusions and Ig fusions. Such fusion polypeptides, particularly poly-His fusions, can facilitate the purification of recombinant polypeptide. In certain host cells (e.g., mammalian host cells), expression and/or secretion of a polypeptide can be increased by using a heterologous signal sequence. Therefore, in another embodiment, the fusion polypeptide contains a heterologous signal sequence at its N-terminus.  
     [0069] EP-A-O 464 533 discloses fusion proteins comprising various portions of immunoglobulin constant regions. The Fe is useful in therapy and diagnosis and thus results, for example, in improved pharmacokinetic properties (EP-A 0232 262). In drug discovery, for example, human proteins have been fused with Fe portions for the purpose of high-throughput screening assays to identify antagonists. Bennett et al.,  Journal of Molecular Recognition,  8:52-58 (1995) and Johanson et al.,  The Journal of Biological Chemistry,  270,16:9459-9471 (1995). Thus, this invention also encompasses soluble fusion polypeptides containing a polypeptide of the invention and various portions of the constant regions of heavy or light chains of immunoglobulins of various subclass (IgG, IgM, IgA, IgE).  
     [0070] A chimeric or fusion polypeptide can be produced by standard recombinant DNA techniques. For example, DNA fragments coding for the different polypeptide sequences are ligated together in-frame in accordance with conventional techniques. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA synthesizers. Alternatively, PCR amplification of nucleic acid fragments can be carried out using anchor primers which give rise to complementary overhangs between two consecutive nucleic acid fragments which can subsequently be annealed and re-amplified to generate a chimeric nucleic acid sequence (see Ausubel et al.,  Current Protocols in Molecular Biology,  1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST protein). A nucleic acid molecule encoding a polypeptide of the invention can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the polypeptide.  
     [0071] The isolated polypeptide can be purified from cells that naturally express it, purified from cells that have been altered to express it (recombinant), or synthesized using known protein synthesis methods. In one embodiment, the polypeptide is produced by recombinant DNA techniques. For example, a nucleic acid molecule encoding the polypeptide is cloned into an expression vector, the expression vector introduced into a host cell and the polypeptide expressed in the host cell. The polypeptide can then be isolated from the cells by an appropriate purification scheme using standard protein purification techniques.  
     [0072] In general, polypeptides of the present invention can be used as a molecular weight marker on SDS-PAGE gels or on molecular sieve gel filtration columns using art-recognized methods. The polypeptides of the present invention can be used to raise antibodies or to elicit an immune response. The polypeptides can also be used as a reagent, e.g., a labeled reagent, in assays to quantitatively determine levels of the polypeptide or a molecule to which it binds (e.g., a receptor or a ligand) in biological fluids. The polypeptides can also be used as markers for cells or tissues in which the corresponding polypeptide is preferentially expressed, either constitutively, during tissue differentiation, or in a diseased state. The polypeptides can be used to isolate a corresponding binding agent, e.g., receptor or ligand, such as, for example, in an interaction trap assay, and to screen for peptide or small molecule antagonists or agonists of the binding interaction.  
     [0073] Antibodies of the Invention  
     [0074] Polyclonal and/or monoclonal antibodies that specifically bind one form of the gene product but not to the other form of the gene product are also provided. Antibodies are also provided that bind a portion of either the variant or the reference gene product that contains the polymorphic site or sites. The invention provides antibodies to the polypeptides and polypeptide fragments of the invention, e.g., having an amino acid sequence encoded by any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or a portion thereof, or having an amino acid sequence encoded by a nucleic acid molecule comprising all or a portion of SEQ ID NO: 1 which may optionally comprise at least one polymorphism shown in Table 1 (e.g., any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or another isoform or splicing variant or portion thereof). The term “antibody” as used herein refers to immunoglobulin molecules and immunologically active portions of immunoglobulin molecules, i.e., molecules that contain an antigen binding site that specifically binds an antigen. A molecule that specifically binds to a polypeptide of the invention is a molecule that binds to that polypeptide or a fragment thereof, but does not substantially bind other molecules in a sample, e.g., a biological sample, which naturally contains the polypeptide. Examples of immunologically active portions of immunoglobulin molecules include F(ab) and F(ab′) 2  fragments which can be generated by treating the antibody with an enzyme such as pepsin. The invention provides polyclonal and monoclonal antibodies that bind to a polypeptide of the invention. The term “monoclonal antibody” or “monoclonal antibody composition”, as used herein, refers to a population of antibody molecules that contain only one species of an antigen binding site capable of immunoreacting with a particular epitope of a polypeptide of the invention. A monoclonal antibody composition thus typically displays a single binding affinity for a particular polypeptide of the invention with which it immunoreacts.  
     [0075] Polyclonal antibodies can be prepared as described above by immunizing a suitable subject with a desired immunogen, e.g., polypeptide of the invention or fragment thereof. The antibody titer in the immunized subject can be monitored over time by standard techniques, such as with an enzyme linked immunosorbent assay (ELISA) using immobilized polypeptide. If desired, the antibody molecules directed against the polypeptide can be isolated from the mammal (e.g., from the blood) and further purified by well-known techniques, such as protein A chromatography to obtain the IgG fraction. At an appropriate time after immunization, e.g., when the antibody titers are highest, antibody-producing cells can be obtained from the subject and used to prepare monoclonal antibodies by standard techniques, such as the hybridoma technique originally described by Kohler and Milstein (1975)  Nature,  256:495-497, the human B cell hybridoma technique (Kozbor et al. (1983)  Immunol. Today,  4:72), the EBV-hybridoma technique (Cole et al. (1985),  Monoclonal Antibodies and Cancer Therapy,  Alan R. Liss, Inc., pp. 77-96) or trioma techniques. The technology for producing hybridomas is well known (see generally  Current Protocols in Immunology  (1994) Coligan et al. (eds.) John Wiley &amp; Sons, Inc., New York, N.Y.). Briefly, an immortal cell line (typically a myeloma) is fused to lymphocytes (typically splenocytes) from a mammal immunized with an immunogen as described above, and the culture supernatants of the resulting hybridoma cells are screened to identify a hybridoma producing a monoclonal antibody that binds a polypeptide of the invention.  
     [0076] Any of the many well known protocols used for fusing lymphocytes and immortalized cell lines can be applied for the purpose of generating a monoclonal antibody to a polypeptide of the invention (see, e.g.,  Current Protocols in Immunology , supra; Galfre et al. (1977)  Nature,  266:55052; R. H. Kenneth, in  Monoclonal Antibodies: A New Dimension In Biological Analyses,  Plenum Publishing Corp., New York, N.Y. (1980); and Lerner (1981)  Yale J. Biol. Med.,  54:387-402. Moreover, the ordinarily skilled worker will appreciate that there are many variations of such methods that also would be useful.  
     [0077] Alternative to preparing monoclonal antibody-secreting hybridomas, a monoclonal antibody to a polypeptide of the invention can be identified and isolated by screening a recombinant combinatorial immunoglobulin library (e.g., an antibody phage display library) with the polypeptide to thereby isolate immunoglobulin library members that bind the polypeptide. Kits for generating and screening phage display libraries are commercially available (e.g., the Pharmacia  Recombinant Phage Antibody System , Catalog No. 27-9400-01; and the Stratagene SurfZAP™ Phage Display Kit, Catalog No. 240612). Additionally, examples of methods and reagents particularly amenable for use in generating and screening antibody display library can be found in, for example, U.S. Pat. No. 5,223,409; PCT Publication No. WO 92/18619; PCT Publication No. WO 91/17271; PCT Publication No. WO 92/20791; PCT Publication No. WO 92/15679; PCT Publication No. WO 93/01288; PCT Publication No. WO 92/01047; PCT Publication No. WO 92/09690; PCT Publication No. WO 90/02809; Fuchs et al. (1991)  Bio/Technology,  9:1370-1372; Hay et al. (1992)  Hum. Antibod. Hybridomas,  3:81-85; Huse et al. (1989)  Science,  246:1275-1281; Griffiths et al. (1993)  EMBO J.,  12:725-734.  
     [0078] Additionally, recombinant antibodies, such as chimeric and humanized monoclonal antibodies, comprising both human and non-human portions, which can be made using standard recombinant DNA techniques, are within the scope of the invention. Such chimeric and humanized monoclonal antibodies can be produced by recombinant DNA techniques known in the art.  
     [0079] The invention also is intended to cover human antibodies. Their methods for production, isolation purification and use are known to those skilled in the art using standard methodologies.  
     [0080] In general, antibodies of the invention (e.g., a monoclonal antibody) can be used to isolate a polypeptide of the invention by standard techniques, such as affinity chromatography or immunoprecipitation. A polypeptide-specific antibody can facilitate the purification of natural polypeptide from cells and of recombinantly produced polypeptide expressed in host cells. Moreover, an antibody specific for a polypeptide of the invention can be used to detect the polypeptide (e.g., in a cellular lysate, cell supernatant, or tissue sample) in order to evaluate the abundance and pattern of expression of the polypeptide. Antibodies can be used diagnostically to monitor protein levels in tissue as part of a clinical testing procedure, e.g., to, for example, determine the efficacy of a given treatment regimen. Detection can be facilitated by coupling the antibody to a detectable substance. Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, β-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include 125I, 131I, 35S or 3H.  
     [0081] Diagnostic and Screening Assays of the Invention  
     [0082] The present invention also pertains to a method of diagnosing or aiding in the diagnosis of peripheral arterial occlusive disease associated with the presence of the PAOD1 gene or gene product in an individual. Diagnostic assays can be designed for assessing PAOD1 gene expression, or for assessing activity of PAOD1 polypeptides of the invention. In one embodiment, the assays are used in the context of a biological sample (e.g., blood, serum, cells, tissue) to thereby determine whether an individual is afflicted with peripheral arterial occlusive disease, or is at risk for (has a predisposition for or a susceptibility to) developing peripheral arterial occlusive disease. The invention also provides for prognostic (or predictive) assays for determining whether an individual is susceptible to developing peripheral arterial occlusive disease. For example, alterations in a nucleic acid can be assayed in a biological sample. Such assays can be used for prognostic or predictive purpose to thereby prophylactically treat an individual prior to the onset of symptoms associated with peripheral arterial occlusive disease. Another aspect of the invention pertains to assays for monitoring the influence of agents (e.g., drugs, compounds or other agents) on nucleic acid expression or activity of polypeptides of the invention, as well as to assays for identifying agents which bind to PAOD1 polypeptides. These and other assays and agents are described in further detail in the following sections.  
     [0083] Diagnostic Assays  
     [0084] The nucleic acids, probes, primers, polypeptides and antibodies described herein can be used in methods of diagnosis of a susceptibility to peripheral arterial occlusive disease, as well as in kits useful for diagnosis of a susceptibility to peripheral arterial occlusive disease.  
     [0085] In one embodiment, the kit useful for diagnosis of a peripheral arterial occlusive condition associated with a PAOD1 nucleic acid or a susceptibility to a peripheral arterial occlusive condition associated with a PAOD1 nucleic acid comprises primers which contain one or more of the SNPs identified in Table 1.  
     [0086] In one embodiment of the invention, diagnosis of a susceptibility to peripheral arterial occlusive disease is made by detecting a polymorphism in PAOD1 as described herein. The polymorphism can be a change in PAOD1, such as the insertion or deletion of a single nucleotide, or of more than one nucleotide, resulting in a frame shift mutation; the change of at least one nucleotide, resulting in a change in the encoded amino acid; the change of at least one nucleotide, resulting in the generation of a premature stop codon; the deletion of several nucleotides, resulting in a deletion of one or more amino acids encoded by the nucleotides; the insertion of one or several nucleotides, such as by unequal recombination or gene conversion, resulting in an interruption of the coding sequence of the gene; duplication of all or a part of the nucleic acid; transposition of all or a part of the gene; or rearrangement of all or a part of the nucleic acid. More than one such change may be present in a single gene. Such sequence changes cause a difference in the polypeptide encoded by a PAOD1 nucleic acid. For example, if the difference is a frame shift change, the frame shift can result in a change in the encoded amino acids, and/or can result in the generation of a premature stop codon, causing generation of a truncated polypeptide. Alternatively, a polymorphism associated with a susceptibility to peripheral arterial occlusive disease can be a synonymous alteration in one or more nucleotides (i.e., an alteration that does not result in a change in the polypeptide encoded by a PAOD1 nucleic acid). Such a polymorphism may alter splicing sites, affect the stability or transport of mRNA, or otherwise affect the transcription or translation of the gene. A PAOD1 nucleic acid that has any of the alterations described above is referred to herein as a “altered nucleic acid.” 
     [0087] In a first method of diagnosing a susceptibility to peripheral arterial occlusive disease, hybridization methods, such as Southern analysis, Northern analysis, or in situ hybridizations, can be used (see Current Protocols in Molecular Biology, Ausubel, F. et al., eds., John Wiley &amp; Sons, including all supplements through 1999). For example, a biological sample from a test subject (a “test sample”) of genomic DNA, RNA, or cDNA, is obtained from an individual suspected of having, being susceptible to or predisposed for, or carrying a defect for, peripheral arterial occlusive disease (the “test individual”). The individual can be an adult, child, or fetus. The test sample can be from any source which contains genomic DNA, such as a blood sample, sample of amniotic fluid, sample of cerebrospinal fluid, or tissue sample from skin, muscle, buccal or conjunctival mucosa, placenta, gastrointestinal tract or other organs. A test sample of DNA from fetal cells or tissue can be obtained by appropriate methods, such as by amniocentesis or chorionic villus sampling. The DNA, RNA, or cDNA sample is then examined to determine whether a polymorphism in PAOD1 is present, and/or to determine which splicing variant(s) encoded by PAOD1 is present. The presence of the polymorphism or splicing variant(s) can be indicated by hybridization of the gene in the genomic DNA, RNA, or cDNA to a nucleic acid probe. A “nucleic acid probe”, as used herein, can be a DNA probe or an RNA probe; the nucleic acid probe can contain at least one polymorphism in PAOD1 or contains a nucleic acid encoding a particular splicing variant of PAOD1. The probe can be any of the nucleic acid molecules described above (e.g., the gene or nucleic acid, a fragment, a vector comprising the gene, a probe or primer, etc.).  
     [0088] To diagnose a susceptibility to peripheral arterial occlusive disease, a hybridization sample is formed by contacting the test sample containing PAOD1, with at least one nucleic acid probe. A preferred probe for detecting mRNA or genomic DNA is a labeled nucleic acid probe capable of hybridizing to mRNA or genomic DNA sequences described herein. The nucleic acid probe can be, for example, a full-length nucleic acid molecule, or a portion thereof, such as an oligonucleotide of at least 15, 30, 50, 100, 250 or 500 nucleotides in length and sufficient to specifically hybridize under stringent conditions to appropriate mRNA or genomic DNA. For example, the nucleic acid probe can be all or a portion of SEQ ID NO: 1 which may optionally comprise at least one polymorphism shown in Table 1, or the complement thereof, or a portion thereof; or can be a nucleic acid encoding a portion of any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36. Other suitable probes for use in the diagnostic assays of the invention are described above (see e.g., probes and primers discussed under the heading, “Nucleic Acids of the Invention”).  
     [0089] The hybridization sample is maintained under conditions which are sufficient to allow specific hybridization of the nucleic acid probe to PAOD1. “Specific hybridization”, as used herein, indicates exact hybridization (e.g., with no mismatches). Specific hybridization can be performed under high stringency conditions or moderate stringency conditions, for example, as described above. In a particularly preferred embodiment, the hybridization conditions for specific hybridization are high stringency.  
     [0090] Specific hybridization, if present, is then detected using standard methods. If specific hybridization occurs between the nucleic acid probe and PAOD1 in the test sample, then PAOD1 has the polymorphism, or is the splicing variant, that is present in the nucleic acid probe. More than one nucleic acid probe can also be used concurrently in this method. Specific hybridization of any one of the nucleic acid probes is indicative of a polymorphism in PAOD1, or of the presence of a particular splicing variant encoding PAOD1 and is therefore diagnostic for a susceptibility to peripheral arterial occlusive disease.  
     [0091] In Northern analysis (see Current Protocols in Molecular Biology, Ausubel, F. et al., eds., John Wiley &amp; Sons, supra) the hybridization methods described above are used to identify the presence of a polymorphism or a particular splicing variant, associated with a susceptibility to peripheral arterial occlusive disease. For Northern analysis, a test sample of RNA is obtained from the individual by appropriate means. Specific hybridization of a nucleic acid probe, as described above, to RNA from the individual is indicative of a polymorphism in PAOD1, or of the presence of a particular splicing variant encoded by PAOD1, and is therefore diagnostic for a susceptibility to peripheral arterial occlusive disease.  
     [0092] For representative examples of use of nucleic acid probes, see, for example, U.S. Pat. Nos. 5,288,611 and 4,851,330.  
     [0093] Alternatively, a peptide nucleic acid (PNA) probe can be used instead of a nucleic acid probe in the hybridization methods described above. PNA is a DNA mimic having a peptide-like, inorganic backbone, such as N-(2-aminoethyl)glycine units, with an organic base (A, G, C, T or U) attached to the glycine nitrogen via a methylene carbonyl linker (see, for example, Nielsen, P. E. et al.,  Bioconjugate Chemistry,  1994, 5, American Chemical Society, p.1 (1994). The PNA probe can be designed to specifically hybridize to a gene having a polymorphism associated with a susceptibility to peripheral arterial occlusive disease. Hybridization of the PNA probe to PAOD1 is diagnostic for a susceptibility to peripheral arterial occlusive disease.  
     [0094] In another method of the invention, mutation analysis by restriction digestion can be used to detect a mutant gene, or genes containing a polymorphism(s), if the mutation or polymorphism in the gene results in the creation or elimination of a restriction site. A test sample containing genomic DNA is obtained from the individual. Polymerase chain reaction (PCR) can be used to amplify PAOD1 (and, if necessary, the flanking sequences) in the test sample of genomic DNA from the test individual. RFLP analysis is conducted as described (see Current Protocols in Molecular Biology, supra). The digestion pattern of the relevant DNA fragment indicates the presence or absence of the mutation or polymorphism in PAOD1, and therefore indicates the presence or absence of this susceptibility to peripheral arterial occlusive disease.  
     [0095] Sequence analysis can also be used to detect specific polymorphisms in PAOD1. A test sample of DNA or RNA is obtained from the test individual. PCR or other appropriate methods can be used to amplify the gene, and/or its flanking sequences, if desired. The sequence of PAOD1, or a fragment of the gene, or cDNA, or fragment of the cDNA, or mRNA, or fragment of the mRNA, is determined, using standard methods. The sequence of the gene, gene fragment, cDNA, cDNA fragment, mRNA, or mRNA fragment is compared with the known nucleic acid sequence of the gene, cDNA (e.g., SEQ ID NO: 1 which may optionally comprise at least one polymorphism shown in Table 1, or a nucleic acid sequence encoding any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or a fragment thereof) or mRNA, as appropriate. The presence of a polymorphism in PAOD1 indicates that the individual has a susceptibility to peripheral arterial occlusive disease.  
     [0096] Allele-specific oligonucleotides can also be used to detect the presence of a polymorphism in PAOD1, through the use of dot-blot hybridization of amplified oligonucleotides with allele-specific oligonucleotide (ASO) probes (see, for example, Saiki, R. et al., (1986),  Nature  ( London ) 324:163-166). An “allele-specific oligonucleotide” (also referred to herein as an “allele-specific oligonucleotide probe”) is an oligonucleotide of approximately 10-50 base pairs, preferably approximately 15-30 base pairs, that specifically hybridizes to PAOD1, and that contains a polymorphism associated with a susceptibility to peripheral arterial occlusive disease. An allele-specific oligonucleotide probe that is specific for particular polymorphisms in PAOD1 can be prepared, using standard methods (see Current Protocols in Molecular Biology, supra). To identify polymorphisms in the gene that are associated with a susceptibility to peripheral arterial occlusive disease, a test sample of DNA is obtained from the individual. PCR can be used to amplify all or a fragment of PAOD1, and its flanking sequences. The DNA containing the amplified PAOD1 (or fragment of the gene) is dot-blotted, using standard methods (see Current Protocols in Molecular Biology, supra), and the blot is contacted with the oligonucleotide probe. The presence of specific hybridization of the probe to the amplified PAOD1 is then detected. Specific hybridization of an allele-specific oligonucleotide probe to DNA from the individual is indicative of a polymorphism in PAOD1, and is therefore indicative of a susceptibility to peripheral arterial occlusive disease.  
     [0097] The invention further provides allele-specific oligonucleotides that hybridize to the reference or variant allele of a gene or nucleic acid comprising a single nucleotide polymorphism or to the complement thereof. These oligonucleotides can be probes or primers.  
     [0098] An allele-specific primer hybridizes to a site on target DNA overlapping a polymorphism and only primes amplification of an allelic form to which the primer exhibits perfect complementarity. See Gibbs,  Nucleic Acid Res.  17, 2427-2448 (1989). This primer is used in conjunction with a second primer, which hybridizes at a distal site. Amplification proceeds from the two primers, resulting in a detectable product, which indicates the particular allelic form is present. A control is usually performed with a second pair of primers, one of which shows a single base mismatch at the polymorphic site and the other of which exhibits perfect complementarity to a distal site. The single-base mismatch prevents amplification and no detectable product is formed. The method works best when the mismatch is included in the 3′-most position of the oligonucleotide aligned with the polymorphism because this position is most destabilizing to elongation from the primer (see, e.g., WO 93/22456).  
     [0099] With the addition of such analogs as locked nucleic acids (LNAs), the size of primers and probes can be reduced to as few as 8 bases. LNAs are a novel class of bicyclic DNA analogs in which the 2′ and 4′ positions in the furanose ring are joined via an O-methylene (oxy-LNA), S-methylene (thio-LNA), or amino methylene (amino-LNA) moiety. Common to all of these LNA variants is an affinity toward complementary nucleic acids, which is by far the highest reported for a DNA analog. For example, particular all oxy-LNA nonamers have been shown to have melting temperatures of 64° C. and 74° C. when in complex with complementary DNA or RNA, respectively, as oposed to 28° C. for both DNA and RNA for the corresponding DNA nonamer. Substantial increases in T m  are also obtained when LNA monomers are used in combination with standard DNA or RNA monomers. For primers and probes, depending on where the LNA monomers are included (e.g., the 3′ end, the 5′end, or in the middle), the T m  could be increased considerably.  
     [0100] In another embodiment, arrays of oligonucleotide probes that are complementary to target nucleic acid sequence segments from an individual, can be used to identify polymorphisms in PAOD1. For example, in one embodiment, an oligonucleotide array can be used. Oligonucleotide arrays typically comprise a plurality of different oligonucleotide probes that are coupled to a surface of a substrate in different known locations. These oligonucleotide arrays, also described as “Genechips.TM.,” have been generally described in the art, for example, U.S. Pat. No. 5,143,854 and PCT patent publication Nos. WO 90/15070 and 92/10092. These arrays can generally be produced using mechanical synthesis methods or light directed synthesis methods which incorporate a combination of photolithographic methods and solid phase oligonucleotide synthesis methods. See Fodor et al.,  Science,  251:767-777 (1991), Pirrung et al., U.S. Pat. No. 5,143,854 (see also PCT Application No. WO 90/15070) and Fodor et al., PCT Publication No. WO 92/10092 and U.S. Pat. No. 5,424,186, the entire teachings of each of which are incorporated by reference herein. Techniques for the synthesis of these arrays using mechanical synthesis methods are described in, e.g., U.S. Pat. No. 5,384,261, the entire teachings of which are incorporated by reference herein. In another example, linear arrays can be utilized.  
     [0101] Once an oligonucleotide array is prepared, a nucleic acid of interest is hybridized with the array and scanned for polymorphisms. Hybridization and scanning are generally carried out by methods described herein and also in, e.g., Published PCT Application Nos. WO 92/10092 and WO 95/11995, and U.S. Pat. No. 5,424,186, the entire teachings of which are incorporated by reference herein. In brief, a target nucleic acid sequence which includes one or more previously identified polymorphic markers is amplified by well known amplification techniques, e.g., PCR. Typically, this involves the use of primer sequences that are complementary to the two strands of the target sequence both upstream and downstream from the polymorphism. Asymmetric PCR techniques may also be used. Amplified target, generally incorporating a label, is then hybridized with the array under appropriate conditions. Upon completion of hybridization and washing of the array, the array is scanned to determine the position on the array to which the target sequence hybridizes. The hybridization data obtained from the scan is typically in the form of fluorescence intensities as a function of location on the array.  
     [0102] Although primarily described in terms of a single detection block, e.g., for detection of a single polymorphism, arrays can include multiple detection blocks, and thus be capable of analyzing multiple, specific polymorphisms. In alternate arrangements, it will generally be understood that detection blocks may be grouped within a single array or in multiple, separate arrays so that varying, optimal conditions may be used during the hybridization of the target to the array. For example, it may often be desirable to provide for the detection of those polymorphisms that fall within G-C rich stretches of a genomic sequence, separately from those falling in A-T rich segments. This allows for the separate optimization of hybridization conditions for each situation.  
     [0103] Additional description of use of oligonucleotide arrays for detection of polymorphisms can be found, for example, in U.S. Pat. Nos. 5,858,659 and 5,837,832, the entire teachings of which are incorporated by reference herein.  
     [0104] Other methods of nucleic acid analysis can be used to detect polymorphisms in PAOD1 or splicing variants encoded by PAOD1. Representative methods include direct manual sequencing (Church and Gilbert, (1988),  Proc. Natl. Acad. Sci. USA  81:1991-1995; Sanger, F. et al. (1977)  Proc. Natl. Acad. Sci.  74:5463-5467; Beavis et al. U.S. Pat. No. 5,288,644); automated fluorescent sequencing; single-stranded conformation polymorphism assays (SSCP); clamped denaturing gel electrophoresis (CDGE); denaturing gradient gel electrophoresis (DGGE) (Sheffield, V. C. et al. (19891)  Proc. Natl. Acad. Sci. USA  86:232-236), mobility shift analysis (Orita, M. et al. (1989)  Proc. Natl. Acad. Sci. USA  86:2766-2770), restriction enzyme analysis (Flavell et al. (1978)  Cell  15:25; Geever, et al. (1981)  Proc. Natl Acad. Sci. USA  78:5081); heteroduplex analysis; chemical mismatch cleavage (CMC) (Cotton et al. (1985)  Proc. Natl. Acad. Sci. USA  85:4397-4401); RNase protection assays (Myers, R. M. et al. (1985)  Science  230:1242); use of polypeptides which recognize nucleotide mismatches, such as  E. coli  mutS protein; allele-specific PCR, for example.  
     [0105] In one embodiment of the invention, diagnosis of a disease or condition associated with a PAOD1 nucleic acid (e.g., peripheral arterial occlusive disease) or a susceptibility to a disease or condition associated with a PAOD1 nucleic acid (e.g., peripheral arterial occlusive disease) can also be made by expression analysis by quantitative PCR (kinetic thermal cycling). This technique, utilizing TaqMan can be used to allow the identification of polymorphisms and whether a patient is homozygous or heterozygous. The technique can assess the presence of an alteration in the expression or composition of the polypeptide encoded by a PAOD1 nucleic acid or splicing variants encoded by a PAOD1 nucleic acid. Further, the expression of the variants can be quantified as physically or functionally different.  
     [0106] In another embodiment of the invention, diagnosis of a susceptibility to peripheral arterial occlusive disease can also be made by examining expression and/or composition of an PAOD1 polypeptide, by a variety of methods, including enzyme linked immunosorbent assays (ELISAs), Western blots, immunoprecipitations and immunofluorescence. A test sample from an individual is assessed for the presence of an alteration in the expression and/or an alteration in composition of the polypeptide encoded by PAOD1, or for the presence of a particular variant encoded by PAOD1. An alteration in expression of a polypeptide encoded by PAOD1 can be, for example, an alteration in the quantitative polypeptide expression (i.e., the amount of polypeptide produced); an alteration in the composition of a polypeptide encoded by PAOD1 is an alteration in the qualitative polypeptide expression (e.g., expression of a mutant PAOD1 polypeptide or of a different splicing variant). In a preferred embodiment, diagnosis of a susceptibility to peripheral arterial occlusive disease is made by detecting a particular splicing variant encoded by PAOD1, or a particular pattern of splicing variants.  
     [0107] Both such alterations (quantitative and qualitative) can also be present. An “alteration” in the polypeptide expression or composition, as used herein, refers to an alteration in expression or composition in a test sample, as compared with the expression or composition of polypeptide by PAOD1 in a control sample. A control sample is a sample that corresponds to the test sample (e.g., is from the same type of cells), and is from an individual who is not affected by peripheral arterial occlusive disease. An alteration in the expression or composition of the polypeptide in the test sample, as compared with the control sample, is indicative of a susceptibility to peripheral arterial occlusive disease. Similarly, the presence of one or more different splicing variants in the test sample, or the presence of significantly different amounts of different splicing variants in the test sample, as compared with the control sample, is indicative of a susceptibility to peripheral arterial occlusive disease. Various means of examining expression or composition of the polypeptide encoded by PAOD1 can be used, including spectroscopy, colorimetry, electrophoresis, isoelectric focusing, and immunoassays (e.g., David et al., U.S. Pat. No. 4,376,110) such as immunoblotting (see also Current Protocols in Molecular Biology, particularly chapter 10). For example, in one embodiment, an antibody capable of binding to the polypeptide (e.g., as described above), preferably an antibody with a detectable label, can be used. Antibodies can be polyclonal, or more preferably, monoclonal. An intact antibody, or a fragment thereof (e.g., Fab or F(ab′) 2 ) can be used. The term “labeled”, with regard to the probe or antibody, is intended to encompass direct labeling of the probe or antibody by coupling (i.e., physically linking) a detectable substance to the probe or antibody, as well as indirect labeling of the probe or antibody by reactivity with another reagent that is directly labeled. Examples of indirect labeling include detection of a primary antibody using a fluorescently labeled secondary antibody and end-labeling of a DNA probe with biotin such that it can be detected with fluorescently labeled streptavidin.  
     [0108] Western blotting analysis, using an antibody as described above that specifically binds to a polypeptide encoded by an altered PAOD1, or an antibody that specifically binds to a polypeptide encoded by a non-altered nucleic acid, or an antibody that specifically binds to a particular splicing variant encoded by PAOD1, can be used to identify the presence in a test sample of a particular splicing variant or of a polypeptide encoded by a polymorphic or altered PAOD1, or the absence in a test sample of a particular splicing variant or of a polypeptide encoded by a non-polymorphic or non-altered acid. The presence of a polypeptide encoded by a polymorphic or altered nucleic acid, or the absence of a polypeptide encoded by a non-polymorphic or non-altered nucleic acid, is diagnostic for a susceptibility to peripheral arterial occlusive disease, as is the presence (or absence) of particular splicing variants encoded by the PAOD1 nucleic acid.  
     [0109] In one embodiment of this method, the level or amount of polypeptide encoded by PAOD1 in a test sample is compared with the level or amount of the polypeptide encoded by PAOD1 in a control sample. A level or amount of the polypeptide in the test sample that is higher or lower than the level or amount of the polypeptide in the control sample, such that the difference is statistically significant, is indicative of an alteration in the expression of the polypeptide encoded by PAOD1, and is diagnostic for a susceptibility to peripheral arterial occlusive disease. Alternatively, the composition of the polypeptide encoded by PAOD1 in a test sample is compared with the composition of the polypeptide encoded by PAOD1 in a control sample (e.g., the presence of different splicing variants). A difference in the composition of the polypeptide in the test sample, as compared with the composition of the polypeptide in the control sample, is diagnostic for a susceptibility to peripheral arterial occlusive disease. In another embodiment, both the level or amount and the composition of the polypeptide can be assessed in the test sample and in the control sample. A difference in the amount or level of the polypeptide in the test sample, compared to the control sample; a difference in composition in the test sample, compared to the control sample; or both a difference in the amount or level, and a difference in the composition, is indicative of a susceptibility to peripheral arterial occlusive disease.  
     [0110] The invention further pertains to a method for the diagnosis or identification of a susceptibility to peripheral arterial occlusive disease in an individual, by identifying an at-risk haplotype (e.g., a haplotype comprising a PAOD1 nucleic acid). In one embodiment, the at-risk haplotype is one that confers a significant risk of peripheral arterial occlusive disease. In one embodiment, significance associated with a haplotype is measured by an odds ratio. In a further embodiment, the significance is measured by a percentage. In one embodiment, a significant risk is measured as an odds ratio of at least about 2.2, including by not limited to: 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, and 1.9. In a further embodiment, an odds ratio of at least 1.2 is significant. In a further embodiment, an odds ratio of at least about 1.5 is significant. In a further embodiment, a significant increase in risk is at least about 1.7 is significant. In a further embodiment, a significant increase in risk is at least about 20%, including but not limited to about 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, and 98%. In a further embodiment, a significant increase in risk is at least about 50%. It is understood however, that identifying whether a risk is medically significant may also depend on a variety of factors, including the specific disease, the haplotype, and often, environmental factors.  
     [0111] The invention also pertains to methods of diagnosing peripheral arterial occlusive disease or a susceptibility to peripheral arterial occlusive disease in an individual, comprising screening for an at-risk haplotype in the PAOD1 nucleic acid that is more frequently present in an individual susceptible to peripheral arterial occlusive disease (affected), compared to the frequency of its presence in a healthy individual (control), wherein the presence of the haplotype is indicative of peripheral arterial occlusive disease or susceptibility to peripheral arterial occlusive disease. Standard techniques for genotyping for the presence of SNPs and/or microsatellite markers that are associated with peripheral arterial occlusive disease can be used, such as fluorescent based techniques (Chen, et al.,  Genome Res.  9, 492 (1999), PCR, LCR, Nested PCR and other techniques for nucleic acid amplification. In a preferred embodiment, the method comprises assessing in an individual the presence or frequency of SNPs and/or microsatellites in the PAOD1 nucleic acid that are associated with peripheral arterial occlusive disease, wherein an excess or higher frequency of the SNPs and/or microsatellites compared to a healthy control individual is indicative that the individual has peripheral arterial occlusive disease or is susceptible to peripheral arterial occlusive disease.  
     [0112] Kits (e.g., reagent kits) useful in the methods of diagnosis comprise components useful in any of the methods described herein, including for example, hybridization probes or primers as described herein (e.g., labeled probes or primers), reagents for detection of labeled molecules, restriction enzymes (e.g., for RFLP analysis), allele-specific oligonucleotides, antibodies which bind to altered or to non-altered (native) PAOD1 polypeptide, means for amplification of nucleic acids comprising PAOD1, or means for analyzing the nucleic acid sequence of PAOD1 or for analyzing the amino acid sequence of an PAOD1 polypeptide, etc.  
     [0113] Screening Assays and Agents Identified Thereby  
     [0114] The invention provides methods (also referred to herein as “screening assays”) for identifying the presence of a nucleotide that hybridizes to a nucleic acid of the invention, as well as for identifying the presence of a polypeptide encoded by a nucleic acid of the invention. In one embodiment, the presence (or absence) of a nucleic acid molecule of interest (e.g., a nucleic acid that has significant homology with a nucleic acid of the invention) in a sample can be assessed by contacting the sample with a nucleic acid comprising a nucleic acid of the invention (e.g., a nucleic acid having the sequence of SEQ ID NO: 1 which may optionally comprise at least one polymorphism shown in Table 1, or the complement thereof, or a nucleic acid encoding an amino acid having the sequence of any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or a fragment or variant of such nucleic acids), under stringent conditions as described above, and then assessing the sample for the presence (or absence) of hybridization. In a preferred embodiment, high stringency conditions are conditions appropriate for selective hybridization. In another embodiment, a sample containing the nucleic acid molecule of interest is contacted with a nucleic acid containing a contiguous nucleotide sequence (e.g., a primer or a probe as described above) that is at least partially complementary to a part of the nucleic acid molecule of interest (e.g., a PAOD1 nucleic acid), and the contacted sample is assessed for the presence or absence of hybridization. In a preferred embodiment, the nucleic acid containing a contiguous nucleotide sequence is completely complementary to a part of the nucleic acid molecule of interest.  
     [0115] In any of these embodiment, all or a portion of the nucleic acid of interest can be subjected to amplification prior to performing the hybridization.  
     [0116] In another embodiment, the presence (or absence) of a polypeptide of interest, such as a polypeptide of the invention or a fragment or variant thereof, in a sample can be assessed by contacting the sample with an antibody that specifically hybridizes to the polypeptide of interest (e.g., an antibody such as those described above), and then assessing the sample for the presence (or absence) of binding of the antibody to the polypeptide of interest.  
     [0117] In another embodiment, the invention provides methods for identifying agents (e.g., fusion proteins, polypeptides, peptidomimetics, prodrugs, receptors, binding agents, antibodies, small molecules or other drugs, or ribozymes which alter (e.g., increase or decrease) the activity of the polypeptides described herein, or which otherwise interact with the polypeptides herein. For example, such agents can be agents which bind to polypeptides described herein (e.g., PAOD1 binding agents); which have a stimulatory or inhibitory effect on, for example, activity of polypeptides of the invention; or which change (e.g., enhance or inhibit) the ability of the polypeptides of the invention to interact with PAOD1 binding agents (e.g., receptors or other binding agents); or which alter posttranslational processing of the PAOD1 polypeptide (e.g., agents that alter proteolytic processing to direct the polypeptide from where it is normally synthesized to another location in the cell, such as the cell surface; agents that alter proteolytic processing such that more polypeptide is released from the cell, etc.  
     [0118] In one embodiment, the invention provides assays for screening candidate or test agents that bind to or modulate the activity of polypeptides described herein (or biologically active portion(s) thereof), as well as agents identifiable by the assays. Test agents can be obtained using any of the numerous approaches in combinatorial library methods known in the art, including: biological libraries; spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring deconvolution; the ‘one-bead one-compound’ library method; and synthetic library methods using affinity chromatography selection. The biological library approach is limited to polypeptide libraries, while the other four approaches are applicable to polypeptide, non-peptide oligomer or small molecule libraries of compounds (Lam, K. S. (1997)  Anticancer Drug Des.,  12:145).  
     [0119] In one embodiment, to identify agents which alter the activity of a PAOD1 polypeptide, a cell, cell lysate, or solution containing or expressing a PAOD1 polypeptide (e.g., any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or another splicing variant encoded by PAOD1), or a fragment or derivative thereof (as described above), can be contacted with an agent to be tested; alternatively, the polypeptide can be contacted directly with the agent to be tested. The level (amount) of PAOD1 activity is assessed (e.g., the level (amount) of PAOD1 activity is measured, either directly or indirectly), and is compared with the level of activity in a control (i.e., the level of activity of the PAOD1 polypeptide or active fragment or derivative thereof in the absence of the agent to be tested). If the level of the activity in the presence of the agent differs, by an amount that is statistically significant, from the level of the activity in the absence of the agent, then the agent is an agent that alters the activity of PAOD1 polypeptide. An increase in the level of PAOD1 activity relative to a control, indicates that the agent is an agent that enhances (is an agonist of) PAOD1 activity. Similarly, a decrease in the level of PAOD1 activity relative to a control, indicates that the agent is an agent that inhibits (is an antagonist of) PAOD1 activity. In another embodiment, the level of activity of a PAOD1 polypeptide or derivative or fragment thereof in the presence of the agent to be tested, is compared with a control level that has previously been established. A level of the activity in the presence of the agent that differs from the control level by an amount that is statistically significant indicates that the agent alters PAOD1 activity.  
     [0120] The present invention also relates to an assay for identifying agents which alter the expression of the PAOD1 gene (e.g., antisense nucleic acids, fusion proteins, polypeptides, peptidomimetics, prodrugs, receptors, binding agents, antibodies, small molecules or other drugs, or ribozymes) which alter (e.g., increase or decrease) expression (e.g., transcription or translation) of the gene or which otherwise interact with the nucleic acids described herein, as well as agents identifiable by the assays. For example, a solution containing a nucleic acid encoding PAOD1 polypeptide (e.g., PAOD1 gene) can be contacted with an agent to be tested. The solution can comprise, for example, cells containing the nucleic acid or cell lysate containing the nucleic acid; alternatively, the solution can be another solution which comprises elements necessary for transcription/translation of the nucleic acid. Cells not suspended in solution can also be employed, if desired. The level and/or pattern of PAOD1 expression (e.g., the level and/or pattern of mRNA or of protein expressed, such as the level and/or pattern of different splicing variants) is assessed, and is compared with the level and/or pattern of expression in a control (i.e., the level and/or pattern of the PAOD1 expression in the absence of the agent to be tested). If the level and/or pattern in the presence of the agent differs, by an amount or in a manner that is statistically significant, from the level and/or pattern in the absence of the agent, then the agent is an agent that alters the expression of PAOD1. Enhancement of PAOD1 expression indicates that the agent is an agonist of PAOD1 activity. Similarly, inhibition of PAOD1 expression indicates that the agent is an antagonist of PAOD1 activity. In another embodiment, the level and/or pattern of PAOD1 polypeptide(s)(e.g., different splicing variants) in the presence of the agent to be tested, is compared with a control level and/or pattern that has previously been established. A level and/or pattern in the presence of the agent that differs from the control level and/or pattern by an amount or in a manner that is statistically significant indicates that the agent alters PAOD1 expression.  
     [0121] In another embodiment of the invention, agents which alter the expression of the PAOD1 gene or which otherwise interact with the nucleic acids described herein, can be identified using a cell, cell lysate, or solution containing a nucleic acid encoding the promoter region of the PAOD1 gene operably linked to a reporter gene. After contact with an agent to be tested, the level of expression of the reporter gene (e.g., the level of mRNA or of protein expressed) is assessed, and is compared with the level of expression in a control (i.e., the level of the expression of the reporter gene in the absence of the agent to be tested). If the level in the presence of the agent differs, by an amount or in a manner that is statistically significant, from the level in the absence of the agent, then the agent is an agent that alters the expression of PAOD1, as indicated by its ability to alter expression of a gene that is operably linked to the PAOD1 gene promoter. Enhancement of the expression of the reporter indicates that the agent is an agonist of PAOD1 activity. Similarly, inhibition of the expression of the reporter indicates that the agent is an antagonist of PAOD1 activity. In another embodiment, the level of expression of the reporter in the presence of the agent to be tested, is compared with a control level that has previously been established. A level in the presence of the agent that differs from the control level by an amount or in a manner that is statistically significant indicates that the agent alters PAOD1 expression.  
     [0122] Agents which alter the amounts of different splicing variants encoded by PAOD1 (e.g., an agent which enhances activity of a first splicing variant, and which inhibits activity of a second splicing variant), as well as agents which are agonists of activity of a first splicing variant and antagonists of activity of a second splicing variant, can easily be identified using these methods described above.  
     [0123] In other embodiments of the invention, assays can be used to assess the impact of a test agent on the activity of a polypeptide in relation to a PAOD1 binding agent. For example, a cell that expresses a compound that interacts with PAOD1 (herein referred to as a “PAOD1 binding agent”, which can be a polypeptide or other molecule that interacts with PAOD1, such as a receptor) is contacted with PAOD1 in the presence of a test agent, and the ability of the test agent to alter the interaction between PAOD1 and the PAOD1 binding agent is determined. Alternatively, a cell lysate or a solution containing the PAOD1 binding agent, can be used. An agent which binds to PAOD1 or the PAOD1 binding agent can alter the interaction by interfering with, or enhancing the ability of PAOD1 to bind to, associate with, or otherwise interact with the PAOD1 binding agent. Determining the ability of the test agent to bind to PAOD1 or an PAOD1 binding agent can be accomplished, for example, by coupling the test agent with a radioisotope or enzymatic label such that binding of the test agent to the polypeptide can be determined by detecting the labeled with  125 I,  35 S,  14 C or  3 H, either directly or indirectly, and the radioisotope detected by direct counting of radioemmission or by scintillation counting. Alternatively, test agents can be enzymatically labeled with, for example, horseradish peroxidase, alkaline phosphatase, or luciferase, and the enzymatic label detected by determination of conversion of an appropriate substrate to product. It is also within the scope of this invention to determine the ability of a test agent to interact with the polypeptide without the labeling of any of the interactants. For example, a microphysiometer can be used to detect the interaction of a test agent with PAOD1 or a PAOD1 binding agent without the labeling of either the test agent, PAOD1, or the PAOD1 binding agent. McConnell, H. M. et al. (1992)  Science,  257:1906-1912. As used herein, a “microphysiometer” (e.g., Cytosensor™) is an analytical instrument that measures the rate at which a cell acidifies its environment using a light-addressable potentiometric sensor (LAPS). Changes in this acidification rate can be used as an indicator of the interaction between ligand and polypeptide. Known PAOD1 binding partners include Gi/Go, Gs and Gp (Namba et al.,  Nature,  365:166-170, 1993). Thus, these receptors can be used to screen for compounds that are PAOD1 receptor agonists for use in treating peripheral arterial occlusive disease or PAOD1 receptor antagonists for studying peripheral arterial occlusive disease. The linkage data provided herein, for the first time, provides such connection to peripheral arterial occlusive disease. Drugs can be designed to regulate PAOD1 receptor activation which in turn can be used to regulate signaling pathways and transcription events of genes downstream, such as adynelate cyclase, MAP kinase, Rho (GTPase) Phospholipase C, NFkB.  
     [0124] In another embodiment of the invention, assays can be used to identify polypeptides that interact with one or more PAOD1 polypeptides, as described herein. For example, a yeast two-hybrid system such as that described by Fields and Song (Fields, S. and Song, O.,  Nature  340:245-246 (1989)) can be used to identify polypeptides that interact with one or more PAOD1 polypeptides. In such a yeast two-hybrid system, vectors are constructed based on the flexibility of a transcription factor which has two functional domains (a DNA binding domain and a transcription activation domain). If the two domains are separated but fused to two different proteins that interact with one another, transcriptional activation can be achieved, and transcription of specific markers (e.g., nutritional markers such as His and Ade, or color markers such as lacZ) can be used to identify the presence of interaction and transcriptional activation. For example, in the methods of the invention, a first vector is used which includes a nucleic acid encoding a DNA binding domain and also an PAOD1 polypeptide, splicing variant, or fragment or derivative thereof, and a second vector is used which includes a nucleic acid encoding a transcription activation domain and also a nucleic acid encoding a polypeptide which potentially may interact with the PAOD1 polypeptide, splicing variant, or fragment or derivative thereof (e.g., a PAOD1 polypeptide binding agent or receptor). Incubation of yeast containing the first vector and the second vector under appropriate conditions (e.g., mating conditions such as used in the Matchmaker™ system from Clontech) allows identification of colonies which express the markers of interest. These colonies can be examined to identify the polypeptide(s) which interact with the PAOD1 polypeptide or fragment or derivative thereof. Such polypeptides may be useful as agents which alter the activity of expression of an PAOD1 polypeptide, as described above.  
     [0125] In more than one embodiment of the above assay methods of the present invention, it may be desirable to immobilize either PAOD1, the PAOD1 binding agent, or other components of the assay on a solid support, in order to facilitate separation of complexed from uncomplexed forms of one or both of the polypeptides, as well as to accommodate automation of the assay. Binding of a test agent to the polypeptide, or interaction of the polypeptide with a binding agent in the presence and absence of a test agent, can be accomplished in any vessel suitable for containing the reactants. Examples of such vessels include microtitre plates, test tubes, and micro-centrifuge tubes. In one embodiment, a fusion protein (e.g., a glutathione-S-transferase fusion protein) can be provided which adds a domain that allows PAOD1 or a PAOD1 binding agent to be bound to a matrix or other solid support.  
     [0126] In another embodiment, modulators of expression of nucleic acid molecules of the invention are identified in a method wherein a cell, cell lysate, or solution containing a nucleic acid encoding PAOD1 is contacted with a test agent and the expression of appropriate mRNA or polypeptide (e.g., splicing variant(s)) in the cell, cell lysate, or solution, is determined. The level of expression of appropriate mRNA or polypeptide(s) in the presence of the test agent is compared to the level of expression of mRNA or polypeptide(s) in the absence of the test agent. The test agent can then be identified as a modulator of expression based on this comparison. For example, when expression of mRNA or polypeptide is greater (statistically significantly greater) in the presence of the test agent than in its absence, the test agent is identified as a stimulator or enhancer of the mRNA or polypeptide expression. Alternatively, when expression of the mRNA or polypeptide is less (statistically significantly less) in the presence of the test agent than in its absence, the test agent is identified as an inhibitor of the mRNA or polypeptide expression. The level of mRNA or polypeptide expression in the cells can be determined by methods described herein for detecting mRNA or polypeptide.  
     [0127] This invention further pertains to novel agents identified by the above-described screening assays. Accordingly, it is within the scope of this invention to further use an agent identified as described herein in an appropriate animal model. For example, an agent identified as described herein (e.g., a test agent that is a modulating agent, an antisense nucleic acid molecule, a specific antibody, or a polypeptide-binding agent) can be used in an animal model to determine the efficacy, toxicity, or side effects of treatment with such an agent. Alternatively, an agent identified as described herein can be used in an animal model to determine the mechanism of action of such an agent. Furthermore, this invention pertains to uses of novel agents identified by the above-described screening assays for treatments as described herein. In addition, an agent identified as described herein can be used to alter activity of a polypeptide encoded by PAOD1, or to alter expression of PAOD1, by contacting the polypeptide or the gene (or contacting a cell comprising the polypeptide or the nucleic acid) with the agent identified as described herein.  
     [0128] Pharmaceutical Compositions  
     [0129] The present invention also pertains to pharmaceutical compositions comprising nucleic acids described herein, particularly nucleotides encoding the polypeptides described herein; comprising polypeptides described herein (e.g., any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36); and/or comprising other splicing variants encoded by PAOD1; and/or an agent that alters (e.g., enhances or inhibits) PAOD1 gene expression or PAOD1 polypeptide activity as described herein. For instance, a polypeptide, protein (e.g., an PAOD1 receptor), an agent that alters PAOD1 gene expression, or a PAOD1 binding agent or binding partner, fragment, fusion protein or prodrug thereof, or a nucleotide or nucleic acid construct (vector) comprising a nucleotide of the present invention, or an agent that alters PAOD1 polypeptide activity, can be formulated with a physiologically acceptable carrier or excipient to prepare a pharmaceutical composition. The carrier and composition can be sterile. The formulation should suit the mode of administration.  
     [0130] Suitable pharmaceutically acceptable carriers include but are not limited to water, salt solutions (e.g., NaCl), saline, buffered saline, alcohols, glycerol, ethanol, gum arabic, vegetable oils, benzyl alcohols, polyethylene glycols, gelatin, carbohydrates such as lactose, amylose or starch, dextrose, magnesium stearate, talc, silicic acid, viscous paraffin, perfume oil, fatty acid esters, hydroxymethylcellulose, polyvinyl pyrolidone, etc., as well as combinations thereof. The pharmaceutical preparations can, if desired, be mixed with auxiliary agents, e.g., lubricants, preservatives, stabilizers, wetting agents, emulsifiers, salts for influencing osmotic pressure, buffers, coloring, flavoring and/or aromatic substances and the like which do not deleteriously react with the active agents.  
     [0131] The composition, if desired, can also contain minor amounts of wetting or emulsifying agents, or pH buffering agents. The composition can be a liquid solution, suspension, emulsion, tablet, pill, capsule, sustained release formulation, or powder. The composition can be formulated as a suppository, with traditional binders and carriers such as triglycerides. Oral formulation can include standard carriers such as pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, polyvinyl pyrollidone, sodium saccharine, cellulose, magnesium carbonate, etc.  
     [0132] Methods of introduction of these compositions include, but are not limited to, intradermal, intramuscular, intraperitoneal, intraocular, intravenous, subcutaneous, topical, oral and intranasal. Other suitable methods of introduction can also include gene therapy (as described below), rechargeable or biodegradable devices, particle acceleration devises (“gene guns”) and slow release polymeric devices. The pharmaceutical compositions of this invention can also be administered as part of a combinatorial therapy with other agents.  
     [0133] The composition can be formulated in accordance with the routine procedures as a pharmaceutical composition adapted for administration to human beings. For example, compositions for intravenous administration typically are solutions in sterile isotonic aqueous buffer. Where necessary, the composition may also include a solubilizing agent and a local anesthetic to ease pain at the site of the injection. Generally, the ingredients are supplied either separately or mixed together in unit dosage form, for example, as a dry lyophilized powder or water free concentrate in a hermetically sealed container such as an ampule or sachette indicating the quantity of active agent. Where the composition is to be administered by infusion, it can be dispensed with an infusion bottle containing sterile pharmaceutical grade water, saline or dextrose/water. Where the composition is administered by injection, an ampule of sterile water for injection or saline can be provided so that the ingredients may be mixed prior to administration.  
     [0134] For topical application, nonsprayable forms, viscous to semi-solid or solid forms comprising a carrier compatible with topical application and having a dynamic viscosity preferably greater than water, can be employed. Suitable formulations include but are not limited to solutions, suspensions, emulsions, creams, ointments, powders, enemas, lotions, sols, liniments, salves, aerosols, etc., which are, if desired, sterilized or mixed with auxiliary agents, e.g., preservatives, stabilizers, wetting agents, buffers or salts for influencing osmotic pressure, etc. The agent may be incorporated into a cosmetic formulation. For topical application, also suitable are sprayable aerosol preparations wherein the active ingredient, preferably in combination with a solid or liquid inert carrier material, is packaged in a squeeze bottle or in admixture with a pressurized volatile, normally gaseous propellant, e.g., pressurized air.  
     [0135] Agents described herein can be formulated as neutral or salt forms. Pharmaceutically acceptable salts include those formed with free amino groups such as those derived from hydrochloric, phosphoric, acetic, oxalic, tartaric acids, etc., and those formed with free carboxyl groups such as those derived from sodium, potassium, ammonium, calcium, ferric hydroxides, isopropylamine, triethylamine, 2-ethylamino ethanol, histidine, procaine, etc.  
     [0136] The agents are administered in a therapeutically effective amount. The amount of agents which will be therapeutically effective in the treatment of a particular disorder or condition will depend on the nature of the disorder or condition, and can be determined by standard clinical techniques. In addition, in vitro or in vivo assays may optionally be employed to help identify optimal dosage ranges. The precise dose to be employed in the formulation will also depend on the route of administration, and the seriousness of the symptoms of peripheral arterial occlusive disease, and should be decided according to the judgment of a practitioner and each patient&#39;s circumstances. Effective doses may be extrapolated from dose-response curves derived from in vitro or animal model test systems.  
     [0137] The invention also provides a pharmaceutical pack or kit comprising one or more containers filled with one or more of the ingredients of the pharmaceutical compositions of the invention. Optionally associated with such container(s) can be a notice in the form prescribed by a governmental agency regulating the manufacture, use or sale of pharmaceuticals or biological products, which notice reflects approval by the agency of manufacture, use of sale for human administration. The pack or kit can be labeled with information regarding mode of administration, sequence of drug administration (e.g., separately, sequentially or concurrently), or the like. The pack or kit may also include means for reminding the patient to take the therapy. The pack or kit can be a single unit dosage of the combination therapy or it can be a plurality of unit dosages. In particular, the agents can be separated, mixed together in any combination, present in a single vial or tablet. Agents assembled in a blister pack or other dispensing means is preferred. For the purpose of this invention, unit dosage is intended to mean a dosage that is dependent on the individual pharmacodynamics of each agent and administered in FDA approved dosages in standard time courses.  
     [0138] Methods of Therapy  
     [0139] The present invention also pertains to methods of treatment (prophylactic and/or therapeutic) for peripheral arterial occlusive disease or susceptibility to peripheral arterial occlusive disease, using a PAOD1 therapeutic agent. A “PAOD1 therapeutic agent” is an agent that alters (e.g., enhances or inhibits) PAOD1 polypeptide activity and/or PAOD1 gene expression, as described herein (e.g., a PAOD1 agonist or antagonist). PAOD1 therapeutic agents can alter PAOD1 polypeptide activity or gene expression by a variety of means, such as, for example, by providing additional PAOD1 polypeptide or by upregulating the transcription or translation of the PAOD1 gene; by altering posttranslational processing of the PAOD1 polypeptide; by altering transcription of PAOD1 splicing variants; or by interfering with PAOD1 polypeptide activity (e.g., by binding to a PAOD1 polypeptide), or by downregulating the transcription or translation of the PAOD1 gene. Representative PAOD1 therapeutic agents include the following: nucleic acids or fragments or derivatives thereof described herein, particularly nucleotides encoding the polypeptides described herein and vectors comprising such nucleic acids (e.g., a gene, cDNA, and/or mRNA, such as a nucleic acid encoding a PAOD1 polypeptide or active fragment or derivative thereof, or an oligonucleotide; for example, SEQ ID NO: 1 which may optionally comprise at least one polymorphism shown in Table 1 or a nucleic acid encoding an isoform, or fragments or derivatives thereof); polypeptides described herein (e.g., one or more of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, and/or other splicing variants encoded by PAOD1, or fragments or derivatives thereof); other polypeptides (e.g., PAOD1 receptors); PAOD1 binding agents; peptidomimetics; fusion proteins or prodrugs thereof; antibodies (e.g., an antibody to a mutant PAOD1 polypeptide, or an antibody to a non-mutant PAOD1 polypeptide, or an antibody to a particular splicing variant encoded by PAOD1, as described above); ribozymes; other small molecules; and other agents that alter (e.g., enhance or inhibit) PAOD1 gene expression or polypeptide activity, or that regulate transcription of PAOD1 splicing variants (e.g., agents that affect which splicing variants are expressed, or that affect the amount of each splicing variant that is expressed. More than one PAOD1 therapeutic agent can be used concurrently, if desired.  
     [0140] The PAOD1 therapeutic agent that is a nucleic acid is used in the treatment of peripheral arterial occlusive disease or treatment for a susceptibility of peripheral arterial occlusive disease. The term, “treatment” as used herein, refers not only to ameliorating symptoms associated with the disease, but also preventing or delaying the onset of the disease, and also lessening the severity or frequency of symptoms of the disease. The therapy is designed to alter (e.g., inhibit or enhance), replace or supplement activity of a PAOD1 polypeptide in an individual. For example, a PAOD1 therapeutic agent can be administered in order to upregulate or increase the expression or availability of the PAOD1 gene or of specific splicing variants of PAOD1, or, conversely, to downregulate or decrease the expression or availability of the PAOD1 gene or specific splicing variants of PAOD1. Upregulation or increasing expression or availability of a native PAOD1 gene or of a particular splicing variant could interfere with or compensate for the expression or activity of a defective gene or another splicing variant; downregulation or decreasing expression or availability of a native PAOD1 gene or of a particular splicing variant could minimize the expression or activity of a defective gene or the particular splicing variant and thereby minimize the impact of the defective gene or the particular splicing variant.  
     [0141] The PAOD1 therapeutic agent(s) are administered in a therapeutically effective amount (i.e., an amount that is sufficient to treat the disease, such as by ameliorating symptoms associated with the disease, preventing or delaying the onset of the disease, and/or also lessening the severity or frequency of symptoms of the disease). The amount which will be therapeutically effective in the treatment of a particular individual&#39;s disorder or condition will depend on the symptoms and severity of the disease, and can be determined by standard clinical techniques. In addition, in vitro or in vivo assays may optionally be employed to help identify optimal dosage ranges. The precise dose to be employed in the formulation will also depend on the route of administration, and the seriousness of the disease or disorder, and should be decided according to the judgment of a practitioner and each patient&#39;s circumstances. Effective doses may be extrapolated from dose-response curves derived from in vitro or animal model test systems.  
     [0142] In one embodiment, a nucleic acid of the invention (e.g., a nucleic acid encoding a PAOD1 polypeptide, such as SEQ ID NO: 1 which may optionally comprise at least one polymorphism shown in Table 1; or another nucleic acid that encodes a PAOD1 polypeptide or a splicing variant, derivative or fragment thereof, such as a nucleic acid encoding any one of SEQ ID NOs: 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36) can be used, either alone or in a pharmaceutical composition as described above. For example, PAOD1 or a cDNA encoding the PAOD1 polypeptide, either by itself or included within a vector, can be introduced into cells (either in vitro or in vivo) such that the cells produce native PAOD1 polypeptide. If necessary, cells that have been transformed with the gene or cDNA or a vector comprising the gene or cDNA can be introduced (or re-introduced) into an individual affected with the disease. Thus, cells which, in nature, lack native PAOD1 expression and activity, or have mutant PAOD1 expression and activity, or have expression of a disease-associated PAOD1 splicing variant, can be engineered to express PAOD1 polypeptide or an active fragment of the PAOD1 polypeptide (or a different variant of PAOD1 polypeptide). In a preferred embodiment, nucleic acid encoding the PAOD1 polypeptide, or an active fragment or derivative thereof, can be introduced into an expression vector, such as a viral vector, and the vector can be introduced into appropriate cells in an animal. Other gene transfer systems, including viral and nonviral transfer systems, can be used. Alternatively, nonviral gene transfer methods, such as calcium phosphate coprecipitation, mechanical techniques (e.g., microinjection); membrane fusion-mediated transfer via liposomes; or direct DNA uptake, can also be used.  
     [0143] Alternatively, in another embodiment of the invention, a nucleic acid of the invention; a nucleic acid complementary to a nucleic acid of the invention; or a portion of such a nucleic acid (e.g., an oligonucleotide as described below), can be used in “antisense” therapy, in which a nucleic acid (e.g., an oligonucleotide) which specifically hybridizes to the mRNA and/or genomic DNA of PAOD1 is administered or generated in situ. The antisense nucleic acid that specifically hybridizes to the mRNA and/or DNA inhibits expression of the PAOD1 polypeptide, e.g., by inhibiting translation and/or transcription. Binding of the antisense nucleic acid can be by conventional base pair complementarity, or, for example, in the case of binding to DNA duplexes, through specific interaction in the major groove of the double helix.  
     [0144] An antisense construct of the present invention can be delivered, for example, as an expression plasmid as described above. When the plasmid is transcribed in the cell, it produces RNA which is complementary to a portion of the mRNA and/or DNA which encodes PAOD1 polypeptide. Alternatively, the antisense construct can be an oligonucleotide probe which is generated ex vivo and introduced into cells; it then inhibits expression by hybridizing with the mRNA and/or genomic DNA of PAOD1. In one embodiment, the oligonucleotide probes are modified oligonucleotides which are resistant to endogenous nucleases, e.g. exonucleases and/or endonucleases, thereby rendering them stable in vivo. Exemplary nucleic acid molecules for use as antisense oligonucleotides are phosphoramidate, phosphothioate and methylphosphonate analogs of DNA (see also U.S. Pat. Nos. 5,176,996; 5,264,564; and 5,256,775). Additionally, general approaches to constructing oligomers useful in antisense therapy are also described, for example, by Van der Krol et al. ((1988)  Biotechniques  6:958-976); and Stein et al. ((1988)  Cancer Res  48:2659-2668). With respect to antisense DNA, oligodeoxyribonucleotides derived from the translation initiation site, e.g. between the −10 and +10 regions of PAOD1 sequence, are preferred.  
     [0145] To perform antisense therapy, oligonucleotides (mRNA, cDNA or DNA) are designed that are complementary to mRNA encoding PAOD1. The antisense oligonucleotides bind to PAOD1 mRNA transcripts and prevent translation. Absolute complementarity, although preferred, is not required a sequence “complementary” to a portion of an RNA, as referred to herein, indicates that a sequence has sufficient complementarity to be able to hybridize with the RNA, forming a stable duplex; in the case of double-stranded antisense nucleic acids, a single strand of the duplex DNA may thus be tested, or triplex formation may be assayed. The ability to hybridize will depend on both the degree of complementarity and the length of the antisense nucleic acid, as described in detail above. Generally, the longer the hybridizing nucleic acid, the more base mismatches with an RNA it may contain and still form a stable duplex (or triplex, as the case may be). One skilled in the art can ascertain a tolerable degree of mismatch by use of standard procedures.  
     [0146] The oligonucleotides used in antisense therapy can be DNA, RNA, or chimeric mixtures or derivatives or modified versions thereof, single-stranded or double-stranded. The oligonucleotides can be modified at the base moiety, sugar moiety, or phosphate backbone, for example, to improve stability of the molecule, hybridization, etc. The oligonucleotides can include other appended groups such as peptides (e.g. for targeting host cell receptors in vivo), or agents facilitating transport across the cell membrane (see, e.g., Letsinger et al. (1989)  Proc. Natl. Acad. Sci. USA  86:6553-6556; Lemaitre et al., (1987),  Proc. Natl. Acad Sci. USA  84:648-652; PCT International Publication No. WO88/09810) or the blood-brain barrier (see, e.g., PCT International Publication No. WO89/10134), or hybridization-triggered cleavage agents (see, e.g., Krol et al. (1988)  BioTechniques  6:958-976) or intercalating agents. (See, e.g., Zon, (1988),  Pharm. Res.  5:539-549). To this end, the oligonucleotide may be conjugated to another molecule (e.g., a peptide, hybridization triggered cross-linking agent, transport agent, hybridization-triggered cleavage agent).  
     [0147] The antisense molecules are delivered to cells which express PAOD1 in vivo. A number of methods can be used for delivering antisense DNA or RNA to cells; e.g., antisense molecules can be injected directly into the tissue site, or modified antisense molecules, designed to target the desired cells (e.g., antisense linked to peptides or antibodies that specifically bind receptors or antigens expressed on the target cell surface) can be administered systemically. Alternatively, in a preferred embodiment, a recombinant DNA construct is utilized in which the antisense oligonucleotide is placed under the control of a strong promoter (e.g., pol III or pol II). The use of such a construct to transfect target cells in the patient results in the transcription of sufficient amounts of single stranded RNAs that will form complementary base pairs with the endogenous PAOD1 transcripts and thereby prevent translation of the PAOD1 mRNA. For example, a vector can be introduced in vivo such that it is taken up by a cell and directs the transcription of an antisense RNA. Such a vector can remain episomal or become chromosomally integrated, as long as it can be transcribed to produce the desired antisense RNA. Such vectors can be constructed by recombinant DNA technology methods standard in the art and described above. For example, a plasmid, cosmid, YAC or viral vector can be used to prepare the recombinant DNA construct which can be introduced directly into the tissue site. Alternatively, viral vectors can be used which selectively infect the desired tissue, in which case administration may be accomplished by another route (e.g., systemically).  
     [0148] Endogenous PAOD1 expression can also be reduced by inactivating or “knocking out” PAOD1 or its promoter using targeted homologous recombination (e.g., see Smithies et al. (1985)  Nature  317:230-234; Thomas &amp; Capecchi (1987)  Cell  51:503-512; Thompson et al. (1989)  Cell  5:313-321). For example, a mutant, non-functional PAOD1 (or a completely unrelated DNA sequence) flanked by DNA homologous to the endogenous PAOD1 (either the coding regions or regulatory regions of PAOD1) can be used, with or without a selectable marker and/or a negative selectable marker, to transfect cells that express PAOD1 in vivo. Insertion of the DNA construct, via targeted homologous recombination, results in inactivation of PAOD1. The recombinant DNA constructs can be directly administered or targeted to the required site in vivo using appropriate vectors, as described above. Alternatively, expression of non-mutant PAOD1 can be increased using a similar method: targeted homologous recombination can be used to insert a DNA construct comprising a non-mutant, functional PAOD1 (e.g., a gene having SEQ ID NO: 1 which may optionally comprise at least one polymorphism shown in Table 1), or a portion thereof, in place of a mutant PAOD1 in the cell, as described above. In another embodiment, targeted homologous recombination can be used to insert a DNA construct comprising a nucleic acid that encodes a PAOD1 polypeptide variant that differs from that present in the cell.  
     [0149] Alternatively, endogenous PAOD1 expression can be reduced by targeting deoxyribonucleotide sequences complementary to the regulatory region of PAOD1 (i.e., the PAOD1 promoter and/or enhancers) to form triple helical structures that prevent transcription of PAOD1 in target cells in the body. (See generally, Helene, C. (1991)  Anticancer Drug Des.,  6(6):569-84; Helene, C., et al. (1992)  Ann, N.Y. Acad. Sci.,  660:27-36; and Maher, L. J. (1992)  Bioassays  14(12):807-15). Likewise, the antisense constructs described herein, by antagonizing the normal biological activity of one of the PAOD1 proteins, can be used in the manipulation of tissue, e.g. tissue differentiation, both in vivo and/or ex vivo tissue cultures. Furthermore, the anti-sense techniques (e.g. microinjection of antisense molecules, or transfection with plasmids whose transcripts are anti-sense with regard to a PAOD1 mRNA or gene sequence) can be used to investigate role of PAOD1 in developmental events, as well as the normal cellular function of PAOD1 in adult tissue: Such techniques can be utilized in cell culture, but can also be used in the creation of transgenic animals.  
     [0150] In yet another embodiment of the invention, other PAOD1 therapeutic agents as described herein can also be used in the treatment or prevention of peripheral arterial occlusive disease. The therapeutic agents can be delivered in a composition, as described above, or by themselves. They can be administered systemically, or can be targeted to a particular tissue. The therapeutic agents can be produced by a variety of means, including chemical synthesis; recombinant production; in vivo production (e.g., a transgenic animal, such as U.S. Pat. No. 4,873,316 to Meade et al.), for example, and can be isolated using standard means such as those described herein.  
     [0151] A combination of any of the above methods of treatment (e.g., administration of non-mutant PAOD1 polypeptide in conjunction with antisense therapy targeting mutant PAOD1 mRNA; administration of a first splicing variant encoded by PAOD1 in conjunction with antisense therapy targeting a second splicing encoded by PAOD1), can also be used.  
     [0152] The invention will be further described by the following non-limiting examples. The teachings of all publications cited herein are incorporated herein by reference in their entirety.  
     EXAMPLES  
     Example 1  
     Identification of the PAOD1 Gene  
     [0153] Materials and Methods  
     [0154] Population and Genealogy  
     [0155] This study was approved by the Data Protection Commission of Iceland and the National Bioethics Committee of Iceland. Informed consent was obtained from all patients and their relatives whose DNA samples were used in the linkage scan. The original population-based lists of PAOD1 patients covering the years 1980 to 1995 were derived from the two major hospitals in Iceland. All patients had undergone angiography and 85% had angioplasty and/or vascular surgery. Those undergoing vascular procedures for trauma were excluded.  
     [0156] A comprehensive genealogy database that has been established at deCODE genetics, Inc. was used to cluster the patients in pedigrees (Gulcher, J. R., and Stefansson, K.,  Clin. Chem. Lab. Med.  36:523 (1998)). Each version of the computerized genealogy database is reversibly encrypted by the Data Protection Commission of Iceland before arriving at the laboratory (Gulcher, J. R., et al.,  Eur. J. Hum. Genet.  8:739 (2000)). The database uses a patient list, with encrypted personal identifiers, as input, and recursive algorithms to find all ancestors in the database who are related to any member on the input list within a given number of generations back. The cluster function then searches for ancestors who are common to any two or more members of the input list.  
     [0157] Microsatellite Markers and Genotyping  
     [0158] The marker order and positions for the framework mapping set were obtained from the Marshfield genetic map except for a three-marker putative inversion on chromosome 8 (Jonsdottir, G. M. et al.,  Am. J. Hum. Genet.  67:332 (2000); Yu, A. et al.,  Am. J. Hum. Genet.  67:10 (2000); Giglio et al.,  Am. J. Hum. Genet.,  68:874-83 (2001)).  
     [0159] The DNA samples were genotyped using nearly 1000 fluorescently labelled primers. A microsatellite screening set was developed based in part on the ABI Linkage Marker (v2) screening set and the ABI Linkage Marker (v2) intercalating set in combination with over 500 custom-made markers. All markers were extensively tested for robustness, ease of scoring, and efficiency in 4× multiplex PCR reactions. The PCR amplifications were set up, run and pooled on Perkin Elmer/Applied Biosystems 877 Integrated Catalyst Thermocyclers with a similar protocol for each marker. The reaction volume used was 5 μl and for each PCR reaction 20 ng of genomic DNA was amplified in the presence of 2 μmol of each primer, 0.25 U AmpliTaq Gold, 0.2 mM dNTPs and 2.5 mM MgCl 2  (buffer was supplied by manufacturer). The PCR conditions used were 95° C. for 10 minutes, then 37 cycles of 15 s at 94° C., 30 s at 55° C. and 1 min at 72° C. The PCR products were supplemented with the internal size standard and the pools were separated and detected on Applied Biosystems model 377 Sequencer using GENESCAN v3.0 peak calling software. Alleles were called automatically with the TrueAllele program, which performs automated allele calling on DNA fragment data from automated fluorescent sequencers. The software automatically tracks lanes, and assesses the quality of every genotype it calls. TrueAllele uses stutter deconvolution to mathematically remove PCR stutter (“shadow bands”) from the data. See, e.g., U.S. Pat. Nos. 5,541,067, 5,580,728, 5,876,933, and 6,054,268. Alleles were also called automatically with the program DecodeGT (deCODE genetics, Iceland), which was used to fractionate according to quality and edit the called genotypes (Palsson, B. et al.,  Genome Res.  9:1002-12 (1999)). At least 180 Icelandic controls were genotyped to derive allelic frequencies.  
     [0160] Decode-GT is an editing program that works downstream of the allele calling program, TrueAllele (Cybergenetics, Inc.). It is a parametric approach to allele call quality control that eliminates much of the time required for manual editing of the data. Decode-GT is a PC program that runs under Windows NT and has three main functions. First, it sorts the allele calls according to quality measures and can display the electropherograms on which they are based. Second, it checks the allele calls of CEPH control samples to ensure that the gel is properly calibrated. Third, it performs an inheritance check on the results using pedigree information. Decode-GT reads the combined results file from TrueAllele and sorts the data into three categories—bad allele calls, good allele calls, and ambiguous allele calls—sorting is based on a TrueAllele quality measure, the peak heights, and the peak shifts. The aim is that only calls in the ambiguous category need be inspected by the user, thereby reducing dependence on manual editing.  
     [0161] Statistical Methods for Linkage Analysis  
     [0162] In the analyses described herein, multipoint, affected-only allele-sharing methods were used to assess the evidence for linkage. All relatives who did not have an angiogram or surgery for PAOD1 were considered to have “unknown” status. All results were obtained using the program ALLEGRO (Gudbjartsson, D. F. et al.,  Nat. Genet.  25:12-3 (2000)). The S pairs  scoring function (Whittemore, A. S. and Halpern, J.,  Biometrics  50:118-27 (1994); Kruglyak, L. et al.,  Am. J. Hum. Genet.  58:1347-63 (1996)) and the exponential allele-sharing model (Kong, A. and Cox, N. J.,  Am. J. Hum. Genet.  61:1179-88 (1997)) were used to generate the relevant one degree of freedom statistics. When combining the family scores to obtain an overall score, instead of weighting the families equally, the default of GENEHUNTER (Kruglyak, L. et al.,  Am. J. Hum. Genet.  58:1347-63 (1996)), or weighting the affected pairs equally, a weighting scheme was used which is half way between the two in the log scale; family weights are the geometric means of the weights of the two schemes. While not identical, this weighting scheme tends to give similar results compared to that proposed by Weeks and Lange (Week, D. E. and Lange, K.,  Am. J. Hum. Genet.  42:315-26 (1988)) as an extension of a weighting scheme of Hodge (Hodge, S. E.,  Genet. Epidemiol.  1:109-22 (1984)) designed for sibships. The P value was computed two different ways and the less significant one was reported. The first P value was computed based on large sample theory; Z lr =v(2 log e  (10)lod) is approximately distributed as a standard normal random variable under the null hypothesis of no linkage (Kong, A. and Cox, N. J.,  Am. J. Hum. Genet.  61:1179-88 (1997)). Because of the concern with small sample behavior, a second P value was computed by comparing the observed lod score to its complete data sampling distribution under the null hypothesis (Gudbjartsson, D. F. et al.,  Nat. Genet.  25:12-3 (2000)). When a data set consists of more than a handful of families, which is the case here, these two P values tend to be very similar. To ensure that the result was a true reflection of the information contained in the material, and to be considered a linkage result significant, not only was it required that the P value be smaller than 2×10 −5  (Lander, E. and Kruglyak, L.,  Nat. Genet.  11:241-7 (1995)), but also that the information content in the region was at least 85%. For the families in this study, an information content of 85% corresponded to a marker density of approximately one marker every centimorgan. The information measure used herein has been defined previously (Nicolae, D. L., 1999 , Allele sharing models in gene mapping: a likelihood approach.  A dissertation submitted to the faculty of the division of the physical sciences in candidacy for the degree of doctor of philosophy, University of Chicago, Chicago) and implemented in ALLEGRO. This measure is closely related to a classical measure of information (Dempster, A. P. et al.,  J. Roy. Statist. Soc. B 39:1-38 (1977)), having the property that it is between zero, if the marker genotypes are completely uninformative, and one, if the genotypes determine the exact amount of allele sharing by descent among the affected relatives.  
     [0163] ALLEGRO allows exact multipoint linkage calculations involving many markers for general families, and is based on the program GENEHUNTER (Kruglyak, L., Daly, M. J., Reeve-Daly, M. P., Lander, E. S. (1996) Am. J. Hum. Genet. 58:1347-1363.), and its later modification, GENEHUNTER-PLUS. Like GENEHUNTER, ALLEGRO uses a hidden Markov model, but it is considerably faster than Genehunter (typically 20-100 times). Apart from allowing for larger pedigrees (typically 20-30% larger), the speed improvement is relevant for simulation studies. ALLEGRO has much of the functionality of GENEHUNTER and GENEHUNTER-PLUS. Specifically, ALLEGRO calculates multipoint parametric lod scores, NPL scores and allele-sharing lod scores based on the scoring functions S pairs  and S all , reconstruction of haplotypes, estimated recombination count between markers (observed map), and entropy information. The X chromosome is supported in all calculations.  
     [0164] In addition to S pairs  and S all , and the entropy measure, ALLEGRO supports other scoring functions and information measures. Other advantages are improved input and output, and the ability to perform multiple analyses together at little extra cost (with different parametric models, scoring functions and family-weighting schemes). Also, at a cost of 10-30% in run time, ALLEGRO will, if necessary, use recalculation or disk-swapping to cut down memory requirements by a factor of 20-60 compared with GENEHUNTER. ALLEGRO can simulate multi-locus marker data either under no linkage or under linkage. Simulations under no linkage can be used to study the calibration of different methods of calculating P values. One can determine genome-wide adjusted P values for specific families and marker density. Under linkage to a susceptibility gene, ALLEGRO will simulate marker data conditional on the observed disease phenotypes and a given inheritance mode. These simulations can be used to assess the power of a set of families, or the effects of marker density and missing data. They can also be used to compare parametric and non-parametric methods, various scoring functions and weighting schemes, and SNPs versus microsatellites.  
     [0165] After obtaining a significant allele-sharing lod score, in an attempt to understand the contribution of this susceptibility locus, a range of parametric models was fitted to the data. Even when fitting parametric models, affected-only analyses were performed in the sense that an individual is either classified as affected or having unknown disease status. As a consequence, only ratios of penetrances are relevant. A range of single locus dominant, additive and multiplicative models (Risch, N.,  Am. J. Hum. Genet.  46:229-41 (1990)) was fitted. With a complex disease like PAOD1, none of these simple models are likely to be exactly true and the effect of a gene and its variants can only be reliably determined after the at-risk variant, or variants, are identified. However, by calculating the corresponding contribution to the sibling recurrence risk ratio, the fitted parametric models do provide some rough idea as to how much the gene is contributing to the familial clustering of the disease.  
     [0166] In order to assess whether the increase in lod score resulting from subtracting the 35 PAOD1 patients who also had stroke would be likely to occur by chance, 1000 random sets of 35 patients whose status was then changed to “unknown” in an analysis were selected. The P value used is the fraction of the 1000 simulations which produced a lod score increase at the peak locus equal to or greater than that which was observed by changing the affection status of the stroke patients to “unknown”. The same method was used to assess subtracting the 38 PAOD1 patients who also had MI. There, however, the significance of the decrease in lod score was assessed by looking at the fraction of the simulations which produced a lod score decrease greater or equal to that which was observed by changing the affection status of the MI patients to “unknown”.  
     [0167] Physical and Genetic Mapping  
     [0168] For the locus region, a combination of data from coincident hybridizations of BAC membranes using a high density of STSs and the Finger Printing Contig (FPC) database was used to build large contigs of BACs from the RPCI-11 library provided by Pieter deJong (Childrens&#39;s Hospital Oakland Research Institute). BAC contigs were generated by a method that combines coincident hybridization versus the RPCI-11 BAC library together with data mining and the FPC program. Hybridizations were performed using primers from markers in the region of interest according to their location in the Weizmann Institute Unified Database. To close the gaps, new markers were generated from BAC end sequences.  
     [0169] High-resolution genetic mapping was used both to anchor and place in order contigs found by physical mapping as well as to obtain accurate inter-marker distances for the correctly ordered markers (See Table 2 for marker orders and distances used). Data from 112 Icelandic nuclear families (sibships with their parents, containing from two to seven siblings) were analyzed together with the nuclear families available within the PAOD1 pedigrees. For the purpose of genetic mapping the 112 nuclear families alone provided 588 meioses, and the total number of meioses available for mapping was over 1000. By comparison, the Marshfield genetic map was constructed based on 182 meloses. The large number of meiotic events within our families provides the ability to map markers to a resolution of 1.0 cM or better. Using a modification of the ALLEGRO program, the EM algorithm (Dempster, A. P. et al.,  J. Roy. Statist. Soc. B 39:1-38 (1977)) was applied to the data to estimate the genetic distances between markers. Combining this information with the physical map resulted in a highly reliable order of markers and better estimates of inter-marker distances within the peak region, both of which are important for an accurate linkage analysis (Halpern, J. and Whittemore, A. S.,  Hum. Hered.  49:194-6 (1999); Daw, E. W. et al.,  Genet. Epidemiol.  19:366-80 (2000)).  
     [0170] The PAOD1 Gene  
     [0171] The PAOD1 human genomic sequence (SEQ ID NO: 1) is set forth in FIG. 4 and comprises 322,101 nts (partially described in Genbank Accession Nos. &gt;gi|4775605|emb|AL031429.11|HS333A15 and &gt;gi|16972792|emb|AL158087.12|AS158087; entire teachings incorporated herein). This sequence is representative of a healthy individual. The ORF starts at ATG at nucleotide 58,162 of exon 1. There are twelve exons shown, exons 4 and 5 are new. The gene encodes a GPCR, prostaglandin E receptor 3 (subtype 3) protein, which is alternatively expressed. FIG. 3 shows 11 isoforms; EP3g and EP3h are newly reported herein. Exons 1 and 2 are found in all PTGER3 isoforms and code for most of the protein, i.e., the 359 amino acids that make up the extracellular domain and all 7 transmembrane spanning helices. The tail-forming exons make up the different PTGER3 isoforms.  
     [0172] Single nucleotide polymorphisms (SNPs) are listed in Table 1. For known SNPs, the GenBank Accession numbers is provided. The nucleotide numbering is relative to SEQ ID NO: 1. Four additional SNPs have been identified and are identified with the “mut” suffix. In PAOD1 patient versus control studies, two SNPs showed good p-values, as follows:  
                                                      rs571705   p-0.0063           d15ptgSNP697624   p-0.00466                      
 
     [0173] Based upon this, one or a combination of these SNPs can be used to diagnose PAOD1 or predisposition thereto.  
     [0174] Prostaglandin E receptor 3 protein is widely distributed in tissue, including smooth muscle cells, platelets, endothelium and macrophages. They are know to bind to G proteins, including Gi/Go, Gs and Gp. See Namba et al.,  Nature  365: 166-170 (1993).  
     [0175] Results  
     [0176] A genealogy database, together with a population-based list of 1745 patients who had undergone angiography and/or surgery for PAOD1, was used to define families of PAOD1 patients. The study described herein was focused on patients who were related to other patients within 6 meiotic events (a total of 272 patients and 612 relatives within 116 families). FIG. 1 exhibits two of the larger families used in the analysis as well as an example of a family in which a PAOD1 patient is related to another PAOD1 patient who also had stroke. The most prominent linkage was found to chromosome 1p with a lod score of 2.95, although other lod scores above 1.5 also occur on 13q and 18q. Additional microsatellite markers were genotyped and mapped for the chromosome 1p peak region. Using the genome map annotated at deCODE, the multipoint analysis increased the lod score on chromosome 1 to 3.93 (P=1.04·10 −5 ) (FIG. 2). The peak is centered on marker Dl S2895, with markers D1S411 and D1S2855, telomeric and centromeric, respectively, defining a drop of one in lod score from the peak. This locus was designated as PAOD11. The PAOD1 patients in the families that contributed to the linkage did not have a higher rate of diabetes, hypertension, or hyperlipidemia than the families not contributing to the locus, suggesting that this locus might not be a locus for these risk factors.  
     [0177] Our genetic map for 19 markers in the peak region, along with the publicly available Marshfield genetic map, is displayed in Table 2. The Marshfield map differs from our map in both the order of a number of markers for which Marshfield has no resolution and in the genetic distance between markers. When our data is analyzed using the Marshfield map directly, the lod score at the peak is 2.83. Using the correct order for the markers, but the Marshfield distances, the lod score is also 2.83. At the time of our submission the December 2000 freeze of the UCSC draft assembly of the human DNA sequence was available. Our order of markers agreed with the public sequence except for the two markers which are indicated in Table 2. The April 2001 freeze (released June 2001) corrected the order of these two markers, but changed the orders of two other pairs (not shown in Table 2). The August 2001 freeze agrees with the order we have.  
     [0178] Some demographic information as well as the fraction of patients with several risk factors is given in Table 3 for the entire patient set. For the risk factors, we have also displayed the fractions for the set of patients in families with NPL scores of one or more (the patients in these families show an excess of sharing genetic material identical by descent over what would be expected simply due to their relationship). There does not appear to be any substantial shifting in the pattern of risk factors for the patients from these families. This suggests that this PAOD1 locus is not a locus for these risk factors.  
     [0179] PAOD1 is often associated with other forms of atherosclerosis, such as cerebrovascular disease and coronary artery disease, and many of our patients also had a history of stroke and/or myocardial infarction. When the data was reanalyzed after defining those 35 PAOD1 patients (13% of total) who also had history of stroke, as having unknown disease status, instead of as affected, the led score on chromosome 1 increased to 4.93. This increase in the lod score due to subtraction of the stroke patients is statistically significant (P=0.019) (FIG. 2). Subtraction of the 38 PAOD1 patients who also had MI (14%; designating them as “unknown”), resulted in a decrease in the lod score to 2.95. However, this decrease was not statistically significant (P=0.577) and may simply reflect the reduction of the material.  
     [0180] A variety of parametric models, dominant, additive or multiplicative were fitted to this locus. For each of these models it was possible to achieve a lod score over 4.0 at this locus. For example, a dominant model which assumes that the at-risk allele has a frequency of 14% and the penetrance of a non-carrier is zero gives a lod score of 4.26. When fitting the dominant model, 47 out of the 116 families give a positive lod score; of these 38 families have lod scores above 0.1, and three families have lod scores between 0.4 and 0.7. The three families, A, B and C, in FIG. 1 gave lod scores of 0.68, 0.62 and −0.12 respectively, for this model. Note that, even for a family with a negative lod score, some or all of the patients can carry the at-risk allele since they could have inherited it from different sources. A multiplicative model that assumes the at-risk allele has a frequency of 20% and that there is a 7-fold increase in risk for every at-risk allele carried gives a led score of 4.23. These dominant and multiplicative models correspond to sibling recurrence risk ratios of 2.37 and 2.54.  
     [0181] Discussion  
     [0182] In this study of PAOD1, the phenotype was defined as surgically corrected PAOD1 and/or angiographically documented which has many advantages. This decreased the subjectivity sometimes encountered when defining PAOD1 based on the patient&#39;s history of intermittent claudication. This also eliminated the need of relying on the ankle-brachial blood pressure ratio that may vary from observer to observer (Jeelani, N. U. et al.,  Eur. J. Vasc. Endovasc. Surg.  20:25-8 (2000)). Since only about 20 to 25% of PAOD1 patients ever go on to have angiography and surgery, this group represented those who are more severely affected by the disease.  
     [0183] The lack of prominent linkage to PAOD11 to stroke linkage studies suggests that the PAOD1 gene confers a specific predisposition to PAOD1 rather than to stroke or to PAOD1 in those patients with stroke. This increase in lod score with the removal of stroke patients suggests that there may be other strong genetic and/or environmental factors that contribute to both PAOD1 and stroke.  
     [0184] This study suggests that there is both overlap and independence between genetic factors for the major manifestations of atherosclerosis, specifically PAOD1 and stroke. Since PAOD11 is unlikely to be simply a hypertension, diabetes or hyperlipidemia locus, this suggests that additional genetic factors may affect the pathogenesis of atherosclerosis, either directly, in the arterial wall where it takes place, or indirectly, through mediators in the blood, such as mononuclear cells, macrophages, platelets or coagulation factors.  
                               TABLE 1                                          NA                   Position                   Relative to   Amino           GenBank Accession   SEQ. ID   Acid           No.   No: 1   Change                                             rs880099   50656               rs880098   51319           d15ptgSNP372803mu   58777   K (G/T)           rs1005749   59824           rs1005748   59904           rs1005747   59907           rs2050065   61003           rs1022530   81135           rs1022529   81280           rs1022528   81300           rs1022527   81448           rs2179412   82009           rs2143157   82143           rs2206346   84650           rs2206345   84720           rs997997   85220           rs1008484   85767           rs1569593   86008           rs2206344   90773           rs1474663   92830           d15ptgSNP407605mu   93581   W (T/A)           rs5680   94107           rs1983588   102929           rs1983587   102970           rs1883461   112374           rs1883460   112564           rs2050066   116287           rs2223501   122643           rs647921   123629           rs646621   123903           rs646511   123977           rs1409164   125519           rs516647   127273           rs590222   127333           rs879424   127430           rs726764   128023           rs909848   128272           rs909847   128295           rs873658   128380           rs508513   128451           rs484675   128685           rs484538   128739           rs481940   128965           rs479934   129216           rs847735   133322           rs847734   133330           rs653699   136921           rs596829   140456           rs594454   140954           rs594095   141031           rs573688   144853           rs977214   145162           rs661000   149858           rs571705   151923   R (G/A)           rs681196   154249           rs1071020   154700           rs650194   156559           rs500647   157924           rs1409984   157982           rs499641   158040           rs622721   158098           rs847704   160082           rs475468   164731           rs1327459   164891           rs570021   126032           rs541667   126788           rs601934   127067           rs493489   176240           rs645618   176964           rs545983   177931           rs602383   179776           rs2225026   182241           rs1854147   183835           rs942979   197085           rs1327466   197314           rs875727   197683           rs942976   203851           rs942977   203958           rs942978   204229           rs1327464   205184           rs1409989   205650           rs1359835   205928           rs1359834   206057           rs1409165   207317           rs1409166   207541           rs1325948   207601           rs2068651   208554           rs2068652   208578           rs1409977   218055           rs1409978   218318           rs1409981   218552           rs510414   169694           rs625617   172008           rs496216   175953           rs578096   176739           d15ptgSNP690878mut   243243   M (C/A)           rs5703   243338           rs1327460   246377           rs959   253160           rs766433   257197           rs2182324   262299           rs1327461   264672           rs1327462   265905           rs1327463   275747           rs2182707   276879           rs2031750   278230           rs1409987   278567           rs1409988   279596           rs1327453   286548           rs1327452   286855           rs1327451   286942           rs1327450   286948           rs1327456   296563           rs1409976   297783           rs1327455   297999           rs1327454   298032           rs2225110   298214           rs1536535   314267           rs1536261   233025           rs1327449   233497           rs1325949   234229           rs1409985   237149           rs1409986   239923           d15ptgSNP687624mu   239991   Y (C/T)           rs1536534   315254           rs2209748   319665           rs2209747   319670           rs1409980   320253           rs1409979   320291           rs943525   321337                      
 
     [0185]               TABLE 2                          Comparison of marker order and genetic distances                         Marshfield       deCODE genetics                                 Genetic   Marker       Marker   Genetic       distance (cM)   map       map   distance (cM)                                         96.04   D1S438       D1S438   91.808       97.49   D1S515       D1S515   92.797       98.21   D1S2684       D1S2684   93.257       98.21   D1S2866       D1S2866   94.964       99.30   D1S198       D1S198   95.980       100.39   D1S2829 a         D1S2806   97.783                                                         100.39   D1S2806       D1S2829   97.788       101.48   D1S411       D1S2803   99.120                                                         101.48   D1S2803       D1S411   100.099       102.02   D1S2895       D1S2895   102.020       104.23   D1S464       D1S464 b     104.358       104.23   D1S2855       D1S481 b     104.363                                                         104.23   D1S481       D1S2855   104.368       105.45   D1S2876       D1S2876   107.276       106.45   D1S2618       D1S2841   107.775                                                         106.45   D1S2841       D1S2618   108.378       107.56   D1S500       D1S500   108.644       107.56   D1S465       D1S465   109.234       109.04   D1S430       D1S430   109.840                                    
     [0186]               TABLE 3                          Demographics and risk factors of patients in the study                                 Mean   Sex (n = 272)       All (n = 272)   NPL &gt; 1 (n = 75)                                     age (yrs)   Male (%)   Female (%)   Risk factor a     (%)   (%)                                             70.8   169 (62)   103 (38)   Hyperlipidemia   33.8   39.2                   Hypertension   51.8   48.6                   Diabetes   9.9   9.5                   Smoking b     77.6   85                                    
     [0187]               TABLE 4                       Features of FIG. 4                                            CDS 58162-59061           CDS 93255-93437           misc_feature: internal splice site 93435-93436           CDS 93435-93524           3′UTR 93525-94233           CDS 94357-94581           3′UTR 94579-95040           misc_feature: splice site           94281-94282           misc_feature: splice site           94355-94356           CDS 98112-98258           3′UTR 98259-99051           CDS 131351-131446           3′UTR 131444-132260           CDS 131351-131442, 134006-134012           3′UTR 134006-134734           CDS 151950-151979           CDS 152680-152757           3′UTR 152758-153754           CDS 236419-236497           CDS 239904-240051           CDS 243340-243368           3′UTR 243366-244167           CDS 252878-252898           3′UTR 252896-253623                        
     [0188] While this invention has been particularly shown and described with reference to preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.  
    
     
       
         1 
         
           
             36  
           
           
             1  
             322101  
             DNA  
             Homo sapiens  
             
               misc_feature  
               (1)...(322101)  
               n = A,T,C or G  
             
           
            1 

tgtgacatat ttaaataagt atgtgacatg gttgaatatg gagaggccca ctatttagcc     60 

aggaagtaaa ctttgacaaa acatccaagt aattcagtaa cttcatagtc acatcatttt    120 

tcagggattt aaatgtatat gtgtttggct tttctgattc atgtcattac tctttcaatg    180 

atagaatgga catggtacat tgcgctgaga ggaatacctc attacctttc acgttctctg    240 

aattgcacag tgttgcctaa aaatatcttt tcaccagaag agcctagaac agcactcaaa    300 

agagagccgt gtttgccctt acactgatct tagtcagtag acaccaatgg attattgagc    360 

tgcatgctgc tcataaatca acacatatta tgcttatatt gtcctgcatt ttagtctttc    420 

atctatgtac taagggacat ttaatgttaa actaatgtaa gaattgtctt ttatctgtat    480 

ggtttgtttc ggattatttt ctttagtata tttaccaatg accaacctct tcaaaacttc    540 

atacatactg atgatctatg taacgtatcc agggaaataa ttttatttct ctcaagaaaa    600 

aagttacata ttcaatgaat caatattcag actatgatga aaatcaactt tttgacaaca    660 

taatcatgct gtagttgaag attttattgg tgccacaaag aagtcaattc taaaatagat    720 

ctgtaataga agctcactgg ctattcacct gaactctgtt cacataggag gtaatattgg    780 

ttcaagtatt attaaagcac atgaaaagat aaaaagtaag ccttatgaca taaaattaat    840 

tccagaaaat tgactagttc taggtgatac attaacctga taattttgag aatttcagtt    900 

gttgtctaat gctaaggtat atgaactcga tagacatata attcttacgt ggcaagaata    960 

tagctcctaa ttaacatttg agggataaca ggaaattcta caccagatac caaagggata   1020 

acaggaaaat ctacaccaga tacagataag caggatggag gcactagcta atagcgctga   1080 

acctaggatt agaagatcag atttgatctt acacaaacca gtgactgtga tactacatat   1140 

gtctttgagc ccacatttct tgatctttaa aatgaaagca aaaacacctc ttttacaggg   1200 

tggtggagac agtaatggga aataatagat gtagaaatgc tttgtaaatt ctaaagtggt   1260 

ctagaaatat aagatactat ctcttctgtt tcttgttagt gccatcccgt aagctatcaa   1320 

ggcatagtaa taatcctgga aagcacaaat ttaaggcaaa acatttgtca aagaaacctg   1380 

attggaagaa gcaatataaa caagtttaat gaacagtctt tcctatgttt ccggatacaa   1440 

tggtaagtaa aatattacca cagatattaa ataaaagctt ctattaaaaa ggctgtgcta   1500 

aaatgcacac agagcctaag agatccattc cataggaatt catacagtca agcctagcaa   1560 

tgtctgaact gttatccaag caaactgtct caaaaattaa tcaattgata aaaaaattaa   1620 

tcaattggaa ttactatcac aacaccaaca caggtgaagg tagtggcatg ctgttcctgg   1680 

ggtatctaca tgtctgctag atacctgtta atatccagtt aaataaataa taggctgcaa   1740 

aaatggaaaa agccattgct tatgtcagtg atagaaaaaa aaatgtctag aaataaggaa   1800 

agaattagtg ataagttgag cacatggaat agctaccact ttaaaagcta tgtggactta   1860 

ggcttcccag aagtcccaga cctgtcattc tcctagctac tatcactcct tacaccaaag   1920 

ccgtcaggtt tgaataatag aaaagctctg gataccgagc tcactgagag ggaggcaatt   1980 

taactatccc tccatagtcc cggttttttc ttccctgaca gctgcaatgt cttccgagaa   2040 

tgaccttcca tagcaatgat gaaaaatgag agttgaagaa aaagattgtc acaaattcaa   2100 

actaaaggat tggtaaaata gtttaataag gtaagcgata taattttaga attgaaaacc   2160 

atatactcca aaccagaatt ttcttctaag cctcctttag ttggttaaga ctctaccatt   2220 

cttggcagtt acttaagctc aagtatattt gatcaccctt attataatct ttaaattcta   2280 

caaaataaca gtcacttgga taaattgtgg tatatttata tactagaata tcatcaaaca   2340 

atgaaaataa gtgagccaca gatacattca acagcatgta tgagtctcat caacattgtt   2400 

aggtgaaaga agttagacat aaaataatat attttatgta atgacaggta tatagaatta   2460 

aaaaatagtc actcctggtc tacggtgtta gaggtcagtg gagtttcctt gagagagaaa   2520 

aaaaggtatg ttctttgaaa gggctgaatg ggctttctga tatgttggaa atgttttatt   2580 

ttgtgatctg ggtagtgatt tcataggagc attaactttg taataatcta tgaaatggac   2640 

acttatcttt tatgcacttt tctgcacttt aaaaaattat gtaagttctt agtttggcct   2700 

ttaaggttga ccatgattat ttcccaatgt gttactccaa cctcaccctc aagttgcctc   2760 

cctaaatatt ttattccaac tatgttgctt tattcatgca tctcaaacaa ggttgtatta   2820 

ttttttaacc ctgttctttt gcttttgctg tttctaacta gaagtcatct tctgtctctt   2880 

catatcaaaa tcccaaccat ttttcagagc tcaactatac gtcttttatg tagccttccc   2940 

tcatttcagc aaatgttctt tctccatttt ctgagttgca acgatcattt gaacctctct   3000 

catcaatttg attttaatta cccctgaatt aaaaataagt tcatttgttt tattatgtaa   3060 

caggtatata aattattgga gagctgggaa ctatatacta catatcttga aattcttttc   3120 

cttacttcac agattagctg tacctggtgc taagtggata attgaatgag tctgtgaata   3180 

aataagcaaa taagccactg agtcaattat ttataaacat ctataattat tatacacctc   3240 

tgaggggccc ttggatcaag tttcatccca gcccatgaat aagtgttggt aagtcctcca   3300 

gtgtcctctt ggttctggcc aacaaatcag tagatgagtg gtggaaagtt atacaatatg   3360 

ttgtacctta ctacacccca aaagtgagag agaaatagac tgaaagtcta gaatcagtaa   3420 

atatactacc tgcccaagac aaaattgtga aatgagaagt tgatccttct ctacctttcc   3480 

tccaaggatc atgcctttgt ccaatcccac ctccacactg tctttctcct cttcctcctt   3540 

tattttcaga ggtcaatagt gacatctgtt gattgctgta ttcaagttct ctaaagaaac   3600 

agagccaaga ggatatgcgt atgcaaattt ccatgtcaag ggcaaagcaa gaaggttatt   3660 

gcaggatcta ctctgcaagg ttgccaaagg cctatgttct tggcacatga ctgaggcaaa   3720 

gcttcaccag atgtccttat acccacacta ctgccttaag ggatggcagg cagcctgaca   3780 

cctttttcct gaaatcagca tcctctgctg agaaaggtta acataggtct cactttaaag   3840 

gagaaatact aaaaggaatt gtctattatc atagaatata tattgaaggg tgaatttgga   3900 

gccaagaggc aataacttga taactggcat ataggctatg agtatcagtt atgagagcca   3960 

ataaattccc ttttggtttt agatcttttc agctggattt tctgaatatt gtacagaaag   4020 

actgttaact gacaaaaggc ccagtcctca taccacctag agcaaagcag agtttttcgt   4080 

tgaatattct tttctgagtc tttctgccac tattttccct caaaatcttt ctgccctggt   4140 

cctgtttttt ttagttagaa ttctacatat tgtctttgat atatacgtta aaagcctgtc   4200 

aacaacatat ttttatttta ataatagaat tatagaaaat gaaggcttta aaacagaaga   4260 

ttgatagagt taggtatttt taaaagttaa tagaatatct taggacaaca ggcactttgg   4320 

tttccttcaa ataattaagc tataatctat aataacaaaa catagttaga atttttaatt   4380 

caattaggat tgctctcaaa tctgcctggt aattctagga ttgcaccttg acaacaaaac   4440 

atggtcccaa aagaaagcat ttattttcag taaaaaataa aaatacctaa gtaagcaact   4500 

ttaatagggt ttacatgagt ttcagttaaa agtaagatat ctaatgcaaa agacaattgc   4560 

tttctgtgtt atttttaaaa acagaagtgc caaagagtag aggaattaag aaagtaaaaa   4620 

ctttacacaa tggtaaaaaa tgtgttagtg gctaaaaaaa ttactttatg aagtagactc   4680 

ccaaggaatg tataaaagtt tccaattaga caatattggt tctttgaaaa gtttcatttt   4740 

aagatttaga ctaacatata tcttttttta ttcttgactt cagcaatttc ttctaactgc   4800 

ctcagtagtc ttgtcttcct tgggttttat aaccacaaag tttattatta aaaagtttta   4860 

gttcacctca aatactttct gtgttatttg gtaaaagtat ctaggggaaa attcacgtaa   4920 

gaagagtaaa cccaatttaa cagaaaacat gaaaaattgt tgatgaaggg gtttctgtgt   4980 

gtgtgtgctc agcccaaagg aagcattgga ctggctctgg gagtgggacg cagcgtgaaa   5040 

agatgtagta tctcctcctc tgcctgcttg tgttggataa gtggatcatt ttattgtcag   5100 

gttggctgag actgagcatc aacattatac aggaaagtcc caaaggtatg cagcagaggg   5160 

gatgctatac cagtctcctt cacttgatgc tattaaatga gctcacagtc tgtaagataa   5220 

aagttagata cattgaagga aaataagtac ctagttttat agcagtactt tatgttcaaa   5280 

ctcctcatga gtttatacat gtttctatag agagactgca tctaaaacaa cgctcttaac   5340 

aaatgaaatt tacaagaaaa aacaagctct gtgaattgct atactgatga gtgttttttt   5400 

ctttcaataa cagtagtaca atagtcactt acaatgtctg aacattctaa gccctaacta   5460 

tagatattat atttgattta aaatttcata aatatgttct atgctcatct agaaattttt   5520 

tcctgtgtta cacataaaga acattcatcc attcattcca caaaaacata tttgttacct   5580 

tctatatgcc aggaaaccat gatttctgcc tttgtaaatc tgtctagcat atgagaaaga   5640 

gtttttgctc taaaaatctg tgattatcat gtgttaaatg ggcaccacac ttcaaccagg   5700 

aataataatc atttttatat aatgatacaa tttccagagt gcacacacgc atacatatat   5760 

gtatggaaag agagagagat aatggtaata ttcaatatat ttaccaactg ctacagtaca   5820 

ggttccaaca aacctaaatg caaatggaat aagattgatt ttggaaaaga tctatagaat   5880 

acagaatctc agccattatg tccagttgca actatggttt agcaagctcc cactgatcca   5940 

aagacaggac cttaaactgg gaccttttcc ccatcttctc actataatat gagaacttaa   6000 

aagaggttat aatattggaa attagaaatt gatcattaat acatatttat tactttcata   6060 

ctatatgtca aaaactttgc ctggtgttca atcgagacaa gcctagcttc aggttaccaa   6120 

ggaataaata taaaataaac aataagcagg gggtacaatg agagaatact gattgtggta   6180 

gaagcatggc tgaggaggaa gttgtagaaa gagaatggaa aagcaagtaa aaaaggagat   6240 

cattattaaa gcaagaactt gcaagaggga gaaggtttga ggtcaaaggc aagaggaaag   6300 

gggtaaaaaa ggaagaatga ctatgttgaa ggaggaaaga aaataaggat ggataagaac   6360 

tgtaaatcaa tttagagttg caggagaagt agaataagtc cagaatgata ggaatctgga   6420 

aggaaagata gaggatcatc cagaatgaaa agaatagatg aactccagga agaagttata   6480 

aaggaaaatt ttcctgactg taacaactat ttcctctgtg aagtagggaa ggtaatctgc   6540 

aaagaataaa gagtgcagca ttaagtacaa agtataaaaa gctgtaaaaa ttttaaaaag   6600 

aaagcgtcat aggaaatagg taagtatctg taaagatttc ctagaaaaag attaagagtc   6660 

caacagatgt cagaaatcat aaatgtgtaa ggcagacaga caatcaatat ggttatgtga   6720 

tttgctccag gattattcag tgcctggttt caggatcaga acaaacagat ggttgggtta   6780 

ttctagaatc gaggattagg aataatggaa tgagaagaag gtcgtgagag tgttgggaaa   6840 

taagagcgtc agtgagagag aggtttaact gaatgaccat ggattgtcag ctggagtgaa   6900 

taaggaaatg aagccagaga agtcttattg atcaagaaca tacgaaactg acaaagtaca   6960 

gaagaatcaa tgagagtgaa gagcagtcat tcccctgaat gaaacccctc tgggtattct   7020 

gcagcctgga tgataaagtg ccattacttc ttaaaacata caagactgtt tataatcttg   7080 

cctgcctctc aagctcattt ctaattcctt ttcccaaatg cctccaggca ttctgtatgt   7140 

cctgtcaggc agaccaaata tgatgctttc tgtcttcatg ttactgctgt tctttcaaag   7200 

ggctcctctt cttctcctaa acttcctgtc ctctattcac taatgaactt ctcagttttc   7260 

aagacccact tcaagcatct ttcttattaa agtcacgtgt agtacttagt atgaaaaaaa   7320 

atggccgcca aaatttcctt ccacccttat acagtcatgc cattactccc accaaaaaac   7380 

cccttgattc tgggcaaaca aacagaatgc tgtagaactg acactattcc agttccagcc   7440 

taacccaact gccatattgc gaagaagttc aggctatctt gcctggagta tgagatacca   7500 

tgcagacaga aaatcataga gaggagagat tgcatatagc aactatacct cagacatatg   7560 

agtgagatct tcttggccat tcctgttcat cccaaccacc agatgaatgg aggtggagcc   7620 

cagtcaaccc acagaattat gggaaataag gaatcatttc cattttaagc cactatgttt   7680 

tagggtttag ttattcattt ctagataaat gatatctctc ccattttcaa cttaagtgta   7740 

actgttcaaa ctttccactg tatcatacta ctgcatctat aatatacctg tattatttta   7800 

cttatcacac taggattgca aaattgtttt tacatacctg ctcccttcct attctgtgag   7860 

atgaaacaat gtttcagtgc tagggtatgt ttacactatg tgtgcgcata tatgtgtctg   7920 

ttgtgtgagt ctgtattcta agtcctagca cacaacatac aataagtatt taataattga   7980 

cttgaactac attaaatatg gattgagtta gaggaaggta gaaagagaga gctatgaggt   8040 

tcagtcataa gaattttatg gcttatttca taaaaggagc agttccctga ttcacacgga   8100 

aacatgttgg aagtgaagtt ggcttaagga tagtctagga attcaggtgg ggtggtagaa   8160 

tcatcaagga ggtggacttg tggcctacta caattacaaa atttgtgtgg aatggaatat   8220 

ggtgatatcc aatgggaaga gattgtgaac ttcagaaaaa gagaagctgt gaatgacagc   8280 

tttccagtga agaaaaggct cttaaagtaa tagtaaacca ttaagaatat gcagtttcaa   8340 

ccttctcccc aatgcatgtt caagggagaa aaagtcagtc tccatttcac agacttacgt   8400 

ggaagttgta ctttaactaa aggaagtttt cctttaagtc atctgagtgc accttttcag   8460 

tctcctccag cgaccccttt cgttccactg ccactgaaag ctttctacac agtcctctgc   8520 

cattctcact ctacatctct tctctgggcc atgtgagcca ctcccacggc ttcgatcatt   8580 

actggtatct cctactgctg aactttctga ctccatttct tttatgagcg tcagaactat   8640 

tatttacaat tctcttctga atgtctccag tgttttgcct accacttatg taaaactcaa   8700 

gatgttaaga aacgaactga ttatctgata ttcaaaacat gtttttttcc tcccatattt   8760 

cctagtccag taaatggcat actggccact ccatgagtat agaaagaaac agccagcaca   8820 

ctggttaaga gcttggattc tggaattaat gaaacagaat gtgctcaaat ctggccttca   8880 

taaattacta actgtatggt aattctagac tgttcaggct actgtaacaa aataccagaa   8940 

gttgggtcac ttaaacaaca gacattgatt tctctcagtt ctggaggcta agaagtccaa   9000 

gatcagagtt ccaccacatt cagtttctgg tgagggcctt ctttgtggct tgcagaagct   9060 

gccttcttgc tgtgttctca cacagagcta cttctctggt ctcttcttat aagggtacta   9120 

gtgccatcat gagtaccttt atgaacttat ctaaacctat ttacctctta aaagccccat   9180 

ctccaaatgt cattacattg agagttaggg tttcaacata tgaattttgg gggcacacaa   9240 

ttcagtccaa agcagtaacc ttggcaaatt acttaacttt tcagagattc atttttctca   9300 

cctgttagaa tcttcaaaag cttgtgaaga ggattaaata aatgcttatc caaaccctca   9360 

aaactaatca taccaactag atctcttgaa gccattctta ccttctccct ttaccttagc   9420 

acgcacctct tccaagcaac tgatcgccaa attgttactt ccatttctaa agtgtacctt   9480 

aatacgtgcg tttgtccatt gtcacttcca ctgtgctagt atagacctga acatatttca   9540 

atcagactat tcttgacttt gtctaaccca tctttcacac cattgccaga gataatgttt   9600 

ttaaaaatat aaatctgatc atatcctttt tcttcatttt caattttttt tagtagctcc   9660 

ctgtttccta actctctagc caaactctct agcatctgat ttttgcagtc tttctctgaa   9720 

ctacgtttcc agggccactc tacatcattt cccaccattc cttgtattta aaaatgtcat   9780 

tctgtgaaca tattcttctg ccttcatgtc tatttccttt actaaatcct cacccctact   9840 

tttccccgag aattcctgct caaactccaa gacccagctc gaatgtgatt tcctttctgt   9900 

tatcttccca aaacccccag gtgacatagg ttgcaccctc atctgttttc ccacagggct   9960 

gtatacaaac ctgtctaggc tttatcacac tatagtatag ttattaattt acttgtctat  10020 

cttcccagct agactctgag cacttcctca gaggcaagga tagtgaacta tttattcttg  10080 

cattaaaagt ccataataca gttcctcgga aatactagtc agtatatgta agatgcttga  10140 

taaatgttgg ttgaaagatt gaataaataa tctatgtaac tttaatggtg cctgctgtat  10200 

attaattaag ttcaaatttt tcaggtataa gtccaatttt tcaggtatat ataaaaagta  10260 

aatcattaaa actgggcatt gaaagaagta gattatctac acgtattttt cccagcttta  10320 

aaattctata atcttatcgt gaactgagct aaaactcttc tccaggcata taggattaaa  10380 

gtcttgtctg agacagacta aatttgtaga taggatctag tgggttgttt aaggtatatt  10440 

cccaatttat tcattacatt aacttttata aactgtattt tgtgaatttt atacctttca  10500 

attaaacaaa attaaattat atgcaatagc tgatctttca aaatggtaac atggtgaaga  10560 

aagtgttttt ttctgaaacc ttgtcagctt gagtgacatg tgagtaccca gcactaagca  10620 

tctgttaggg aaatcttatt actctgtgtc tgtcactaga aaatgggaac aaacgtcgca  10680 

agacctacat acttaaaatg ttatgatgtg tttttaaaat tgctttccac ataaggtctt  10740 

ttattttatt agaaaattat aagcaaacaa ggcttgttta attgctttca aagtataagc  10800 

acatttcaca tcaaaattgt atcactttca actgctgact tgtgtgagaa agctgtcagg  10860 

ccctggtgcc caagaaaata gtgcaccatg gcagaaattt cttactgaag gatataatgt  10920 

atgctcaatt aaaccaatgc aatgtgtgta atggtttact tctatcttag aacgtactgc  10980 

tagctttctg ttctggaatc agaattttcc taatgcctgg actttttgtt gaatcccatg  11040 

taagaagtga tgcagtcttt gagtttatat ctcagggaag gttgggctct ttttttctcc  11100 

ttttaacatt caaaaattct cagatatatt accttctcat tctgataatc tatatatact  11160 

ctgctccctt tccataattc tcttagctta ctaaatatct tagctaacaa ttaaagaaat  11220 

tatgcatgaa atgctaaaaa ttatagccag cttttcagag gaatcaattg ttggttatag  11280 

tgctattttt cttaaaaaac attgccaaat cctttatttc ttcaaatatc atagatatct  11340 

atatgtgctt caaatgaatg ggaggtaata aaatatgatg gaaaaatcct ggaaaattcc  11400 

aacacacctt atattgtttg ttatttgaca agtttataac aactttgctt ctcttagcca  11460 

gcagagagca cccatagagg tggtagatga taacttttcc acaaaatatc gcaataaaca  11520 

gataacattt aagatatata ttttcatata tattctaaga aaagatgact gctaaacatg  11580 

aattccccat gatagaagga tattgtatgt tactaaactg ccatctactg gatttgttca  11640 

cccagtacac aatatcatct ataaatttgt atttttcaag gaatacatga ctttttttcc  11700 

cagccatttc ctgactttct ttctttccct aattctagca atgtgtgctt ctaatgacca  11760 

ggagaaaaaa ttgcttcaac taattatagt ccaaccaaag tcattcacat catttaagaa  11820 

ttagattgat tattcatagt gtcatgagga cgtgtcaatt tgagacgagg acgtgtcaat  11880 

ttgagacaag aagaggttta aagaggctta cacttttcag agtgccacct gtctccaaag  11940 

ggcacattca ttaagaagct ccaggtgcaa gttgtggaag caaaacagca taatgaagtc  12000 

ctttccctcc ttgtgcacct tttgattaat aacatcctcc ttcagttcta gcagattgca  12060 

caccagtgta tgccacaaga aacctaaaat gcaagcccac ttttctatcc ttctttgaat  12120 

agagtaaatc accatttatc tatgaccaga atcaaaagaa ttaacaaaat aaggtatctg  12180 

tggcacaatc tacttttata agaaaagaac agctaatacg ccgactgata atatttactt  12240 

gataacaatg tataatatgt gtcactgata aaattccacc taatctatct tctctgtcct  12300 

atattcacac atggaaatgc aattgatatt tggctgggtg cagtggctca cacctgtaat  12360 

cccagcactt tgggagacca aggcgggcag attacctgag gtcaggagtt cgagaccagc  12420 

ctggctaaca tggtgaaacc atttctacta aaaatacaaa aaattagacg ggcgtggtgg  12480 

tgcgcacctg taatcccaac tactcagaag gctgaggcag gagaatcact tgaacctgga  12540 

aggcagagat tgcagcgagc cgagatcacg ccattgcact ccagcttggt caaaaagagc  12600 

gaaactctgt ctcaaaaaat aaaaataata ataataaaat aaaaaatgga gaaaattggc  12660 

atttattgag tactatttac tagacttttt tttttttttt ttttgagaca gagtcttact  12720 

ctgtcaccca ggctggaggg cagtgacaag atctcgactc actgcaacct ccgtctccca  12780 

ggttcaagcg attctcctgc ttcagctgcc catatttact agacattttc atgggcgcta  12840 

tcacacttta tctacacagc agcctggtaa ggtaaatacc gttgtcctca ttgtcatcac  12900 

tgaatgtgac tgaagctcaa agtgataata agagctaaca cttattgact acttaatatt  12960 

ttcctggcat tgcctttatt actttagaaa aattgacaca attaattctc aagaccacat  13020 

tatggaatac atgttaccac tgtcctcatt ttattagagg tgactccaag aagctaagta  13080 

acctgcccaa cattacacaa ataatatgca atggagtctg gatttgaccc gagcaaactg  13140 

gtttcaatgc ctgtacctgt caacttcaac attatgctgt ttatgagtgt gtgtgtgtgt  13200 

gtgtgtgtgt gtgtgtgtgt gtatacttca gtattagatg ggctatatta ttgttttgtt  13260 

tctgaaaatt ggtaattgtg tatttattgt caggcatttt acatgtatta tccattagaa  13320 

atacacacat atatgtaata ttttccccat cttactttga taaaactgaa ttttggagaa  13380 

taacaataat aagaataatc acagtaaaca cattacacat atcacatgct agatactctt  13440 

catgagaaga gttttaaaca tagtacatat ttaatactga caacaacaat ataatgcact  13500 

gttatcacta ttatacaggt gaggaaaaag aaaggtagca ccttgaccaa agtcgcaagg  13560 

ctagcagaaa gcagtgcaag aaatctagtt ccagactcat gattttatcc actactctag  13620 

actttgaaac aatttagaat agtcattcct tgtttattgc agcaaatgtt tgcaacacgc  13680 

cttaactata atagcattca tcacaatcaa acattttgtt gcataccaag taaaataatt  13740 

atgcacattt ggtaaagagt aagaaggaat caagcctgta cagtttcaca ttggtcaggc  13800 

ttatgcatag tttcaataat ggtaaaaata aaattcctct cttcatttat cctacaaaca  13860 

tcgagcatta accttgttcc aggtgcttgg gtagtgagaa taatgtttat tttattctgc  13920 

gaagaattgg agatacataa aaacaaatag gtaattgcaa cataaaagga taattgctaa  13980 

gaagaagttt tgcttcctaa atcaaagcca aagctacaaa acactttatg ttacctggtt  14040 

tcatggctcc aaacgaggtc atacacaggg caaaactagg aaaagaataa aaagacagaa  14100 

gaacattctt tcataaatac ataaaataag gtgcttaaaa ttgttataat agttgcaatt  14160 

ttattttaaa ttctgttaac gtttatgtct gaatcacaag tggaagttca aaatagcttt  14220 

atgatatatg tattccttgt ttcacatctg atatttttct ttgagtacta ctccttccta  14280 

gtgggtttgc ctggtcctga gttcccaggt cctcccagtc tggctcatgc caaattcaag  14340 

ctatcatatt aatcagaatt tttagttgca ggtgacagaa ccccagtgca atgtagctta  14400 

agccaaaaga aagtgtgctg acatgactta ggtgactggg aagtccaaga gataagcatg  14460 

cctcagatag agctatattc agggatacaa atgctatatt cagagttcac ttttttccct  14520 

cgtcccactt ctttctcttt aattctctcc atctatcagc tcttattgta tctacttgac  14580 

ttccttttgt gggtaaactt tctctatata ggtgggtctc acattcacat ataccagatc  14640 

agcaactcta atgaagaaaa aacttctctt tcccaataat cctaaatgaa tcctcgggaa  14700 

tattctgatt ggccttgcct ggttcatata ttcagttttc agacaatcac catgattagg  14760 

tgagctaaca cacagaattt gatgctcgaa aaggactcac aaaaatcaga aatagcatca  14820 

agctttccta ataatttcag gagtacaggc aatcaagagg caaagacaga gcagagaaag  14880 

tctgggacat tctgtgtggc tttgccagat gcttcctatc cactgacccc cagtgattga  14940 

ctaggtctct gtacgtagtt ttgctgatta ttaccttaca gagtagaggc gtgtaattta  15000 

taatacatct ccattttata cctcagaatg ttataaaatg gcatgccatt acaagacatt  15060 

cttcagagaa gccatccatg tccccataaa tcaatagatt ccagatttat ttactagaag  15120 

taatccttat ccagggagat cctgctaagg gctttctgta gaaagatctc cttctgtcta  15180 

aaatcattat tctatttatt agggtgtcta gtcagaaagg agattagaat agattacctg  15240 

ccttcctttc tttttcctag tggtgccccc ataggaaagg aagttaatgg tccacagggc  15300 

tagctgcttt actccttccc cccatcagga gactggacat tctgactgaa catcttgaga  15360 

caagaatctc aaactgtgct cgggggtaaa ggaagaacca tgattgacag gcccccagaa  15420 

gcacctggac tgtgagatgg cgatagaaaa gcacgttgag tagatataaa ctgcgagtgc  15480 

tcttgtttat catactgttc ccgtccagac aagagacttt taagagttct aatgatgcta  15540 

taactttcct gttcctaaac tttgtctatt tctctctggt ttctaactgt gaaaaactct  15600 

tcagctatgt tctgtgactc acagatcaca gcaaaagaac aaatagtgac agcaaagaat  15660 

ggaaacaact atgccaaatc ttggagcccg caggaaagaa atgcaaaaga atgctgagta  15720 

gggcctcaca atgaaccctt aagaggagaa agaatatccc aagggttttc catctaggct  15780 

tatgtcctca taaccatttt cttacagaaa tctaaagttc taacatagca aatgaatttc  15840 

tttaacaggc agggtacaca aacaactatc ctactgacct gataatccaa aagaactttt  15900 

tatttggcca agacaacatt tatgtttagg ttgaatttga aaggctttga acagctcatc  15960 

acattttccc tcattcccta gtgttttaca caggcctgca tcattgattt atgttactgc  16020 

ctgaaccctg taaacatttg agtttttctt tcatggttta atacttgatt taactgaaaa  16080 

tccctttata agaatgtaaa ctttaggcag ggtgcggtgg ctcacgcctg taatcctagc  16140 

actttgggag gccaagatga gtgcatcgct tgagatcagg agttccagac aagcttggcc  16200 

aacgtggtga aaccccatct ctactaaaaa tacaaaaatt agctgggagt agcggtgcat  16260 

gcctataacc ccagttactc gggaggctga agcagaagaa tcgcttgacc ccaggaggtg  16320 

gagaggtgga ggttgcagtg agccgagatc gtgccattgc actccagcca gactccgtct  16380 

caaaaaaaaa aaaaaaaaag gacactttaa actgttttta gttatttaca ctaggatgta  16440 

aacagttttt caactgtttt tcactgtggg ggatgagagt ttttgaagaa ggtaagactg  16500 

aaggaataac aggatgggga ctagggtgag ccagatgcct agggttcaac atttaaggag  16560 

gcgctcattc tcaagtgata actccaggct cagcacctga gactgcctcc ttaaatgtca  16620 

tgccctgttt gtgttatttg cctcgctctt atcccagtcc tttaaggata aagtttaacc  16680 

agctttggtt tctgttactt gtgatgaagt atccttaatg catttccctt ccccacccat  16740 

gaactgaggg agtcattctt cctgggaaca cccataatat cctctgatta tacctatact  16800 

atacttacaa cacagttttc tcactattta cacatccata tgcatcggca ctctgtgcgc  16860 

tccttaaaca aagagactgt gacataatct tctttatagc tgcaatatct agtcctgtac  16920 

ctgttgagtg ggtaagtcaa tgaatgaatg gacaaataaa taaatgagtg tgttgtcaga  16980 

attgaacatg ccatacctgc tgtggcatgg cacaggtgtg tgaaatcctt cgtcagtaaa  17040 

aacattttat ttttgctata gatagatggc aaacttcaac ctgcttttat tctaattgtg  17100 

atatgatttt tctcataact ttgtatgtag catttgaatt gttccagttt tttatttaaa  17160 

catacgtgct caagaaagaa ctgcagtaga tttgtgactg acaccgtata tatgcttttg  17220 

ccctcagtct ccagcagggc cagcctcctt gacctaatta gacttctcac tcccacatgg  17280 

ctggtaaata ctataattaa tttataaagg actctgaaac accaactggc aaaaattccc  17340 

tattaatggt ttctacagaa tgaaaagagc atttaagttg taggagagtt gttgttgtgt  17400 

gtgtgtgtgt gtgtgtgtgc gcacatgtat tcacattttt taatgtagtg aatttctaag  17460 

aatgtcaaat cataacacgt actaagtaaa caatgtttaa taacgtcttg tcatttcttt  17520 

cagcacattt attttaaatt tgaaagaaat ctgtgtgaca aaatattctt agagatgtat  17580 

atttggggta tgtgagactt gagtgtccat gaatactcac acacatccca taaactatgc  17640 

cattcttaaa ataaagttaa agagaaaaat atagaccatc agtttaagaa ggatgtctca  17700 

atgatttgag aaagcaacaa ctgtagtggc ctttggagta tttgcctatt cagaagccat  17760 

ggttggcaga atttcaagat ggctcccaag atttctgtgt cctggtgtac atgccctgta  17820 

ttataccctc tctgtgagtg tgggcaggac ctgtgaatac aatgagatgg cactcctttg  17880 

attagtttat gttatatggc aaaggggacg gaaccatttc tcctctgatt acattatatt  17940 

atataagact ttatagcagt aatagttata gtagtagtat atagtagtaa tggtagtggc  18000 

agcagcagca gccaactgga gagaaattct cctgctggct ttggagaagt aaactccgtt  18060 

ttgagatggc catgtaatta ggacctgagg gcagtctcta gaagctgaga gaaccccctg  18120 

gccaacatct cccaagaaaa tagggacctc tgatgtaaag tttcagggaa ctaaattcca  18180 

ctaacaacct gaatatgcct aaaagcttca gatgaaattg cagctccact tggcactttg  18240 

attgctgctt agtgaaaccc taagcagata atccaattaa gctatgccca gacttctcat  18300 

ccacagaaac tgagagatat caaatacatg ttactttaag cttctaaggt tgtggtaatt  18360 

tgttactggg cactagaaaa ccaatacaag acccaacggc tttttctttt ctgtgggcac  18420 

taccctttac tccccttgtc ccacaggagt gcctcctagc agtcaggtct atacattaca  18480 

ccatgatcct gaaaaactga catagctgat tggatagagg tgcacacctg actcaagcca  18540 

gagcaactag agtctggaaa tttgaagaca gggctaagag gctccaggtg ggaatttctt  18600 

gaatggaaga gagatagaaa cttgaacact ttagcaacac tatcttctgt ccagggttgc  18660 

ctgtagatat taaaagccct gaggaaatgt tcgaggagag agagaatcta tctatagcaa  18720 

tcatctgatt acaaaaataa ttataaaagt catggaccca tgtgagatgg agtgatttgc  18780 

tgttaaagag tcaaggtaag gaaaagctga agagagtcaa ggtaaggaaa catagctact  18840 

tattgtccaa tcggtgaaca taaaaatttt ttctagtttc ttggagtcac ctatttgtat  18900 

taattattac taaagaaacc attcctgttc aatttcatat ctaccactgc aaggaaaagg  18960 

tagtaacact attatcattc acaatgcaat ggctcttcag gtcctattat aattggaacc  19020 

gtatagatct ttttgcctct gcagttccat aatgccattt atttaatgct gattacagca  19080 

ttactcatat tgcttcaaca tccattgtac tgcctgtgaa cactggatac taatgactca  19140 

aatggtgtta gtgtatttgt tcatgatgac cacaaacaca ggtctcacac agagaatgca  19200 

ggaaaatgca aacaattatt catactgtgg tcatgttaaa tttattgttt ggaatgtatt  19260 

aatagcattt atttatagaa cttactgcat taacatagaa tggcatatct ctcaaccatg  19320 

tcctctcttg aattgtctag accttaatca ctgcatccct agaatgtgac tcttttaagg  19380 

ttggctgcag ccctgctttc catatatagt tatcagtggt gaagatagat gagaggccct  19440 

ggatagatga aaagagccat cccatttggg caaccagtgt ccatcacttg ttcatcaagg  19500 

cttacaacca acccagaaga gaatgtcacc atgtttatta gaggtaaaaa agacattgat  19560 

tgaaatggcc cattggcttt gtgttgctac agtctcaaaa gccctgaaag gaggcaagca  19620 

ttgccatgat aagtagtgtc tgatatgtga cacggagctt gcagaggggt ggtgtgactg  19680 

ccctaatgcc agcagcaggg tgacggcagg agaccccagg ataaaggatg tctgcagaca  19740 

cacatacctt tttcaagtgc tctccactag aggtggttcc ttggtctgac cagtcaggga  19800 

agagcccaca tactggctca cacagtcagc tccagaccaa ggatgcatgg ggggacagtg  19860 

gtagcccaga gcactgaact catcctgtgt ctgatattag tgaaaatcac cctcaaacca  19920 

ctgaaaaagc atcattctgg tggcccaaac ttgtgcgatg aaagaaataa tgccatgaaa  19980 

gaaataatgc cccagccagt gggagctttg gccctccaag ttgctctcca ggaactggca  20040 

gggccatctg gccctaagcc accctacagg tgctagtacc agagatcctg ctgcactggt  20100 

ggaccctgag catgttaaga gggcaatatg gtcaggaggg cctgaaggga agaaacaaag  20160 

aagccaataa cattttcttt aggcttagga ctgtcccacc caacaggtcc tgctgacctg  20220 

gctggtcccc accaccaaaa gcaatagaac atctcaggac ttccactgtc caggacccac  20280 

atagtactac attttggctc catcctgctg aatggtccaa gacactcgag gggaattagg  20340 

gcacctcaag gaaggccagg tgcaggacca ggctaggagc cctggttgcc caggtctaag  20400 

ggcagtattg cttttttttt ttttttcagt cttctgaact aggtaacaga aaagctagtc  20460 

tgaggaaaga ataacgcata tgcagaacaa attcagcaaa gagacagaga aagggtgctg  20520 

cttgaataga ggatagtttc ttttaggata tttctgaaac tgcattcctg ctctggcatt  20580 

ccatcaaaca ccaccttctc tttataatat gctccccctt tttgttgttt aagtcatttt  20640 

atttttattt ttgttacttg caagcagagt gagccctaat gcaatattta gagccagatt  20700 

cttagctttg taggttcaga aactcaactt taccatttcc accagagcta atctcctggg  20760 

gaccaacata ttaagaggac ccataaacaa ctgatatgca tttcagagtg ccaatttctc  20820 

aatctataaa gagagcttaa tccagatgaa caacttgtgt ggataaattc actctgggaa  20880 

tttcaccaca gtaggttaag tgtgctcagg agagaagaca aattatcaga gggctgtttg  20940 

gtgagcatat aataagaata aagagaatgg gtagaatttt tctttcaaat taggatagct  21000 

gaaatgaatt tcttttgtag gaatatttct ctttgaaaaa tcagctaaag tccttgaact  21060 

caaataacct cttctggtca ttatcagatg tattcacgca ttttgttcat tatcctagac  21120 

ttactataga ggatttttct cttgacacat aattctccca gaaaaatttt gctaattaca  21180 

gttagtacag ttgattaact gttgttgcat taactgcatg tcatctacca gctttggcat  21240 

ctattattcc tattgacccc atgaagtcac tatctcctct ctactcccaa gggtgatcac  21300 

tatccaagat tagtttggct gcttttgaac ttcatgtaaa tggagtcata tagcatatgc  21360 

cattttgtgt cttgcttttt tcaattcaag actgtatttg tgagtgaaat actgttcaat  21420 

aatctgagtg taatttgtta ttcttgctac tgtattacac attccaactg tgtaaacata  21480 

tgacaattta tttatctagg ctaccactga taagcaattg ggaagcttcc agtttgggct  21540 

attttgaata gtacagctct gaacattact atatacatct tcagtgaaca ttatgtgcat  21600 

tcctgttggt aatataccta aaaatggaat ttcagggtca tagtgtacga aaatgttcag  21660 

atttaatata ttccgacatt ttccaaagta gatgtatcaa ttactttttg caatgtatga  21720 

gaattacagt tgctctacat gctttccaac acttagtatt ctctgatttt tcattttagt  21780 

cagtttgatg aatgcataat ggtatcatat ggttttaatt tgcattcccc tgacttgcag  21840 

taccaaccaa gacatagaaa gcccacaata acctatcttt cctaatgatt acagtgagaa  21900 

actcaagaca aaataccaaa agcaactgcc tgaagactct ggaaaaacaa aaacaaaaac  21960 

aggtaaattg gagtggagaa tgaaaacctg gagaaatgtt ctgtatgttt gcttttcctc  22020 

ttttctcaca gcttttgacc taaggcccaa cacctagtga aactgtggtg acaggaaaaa  22080 

ccgacagaaa cctgtatgtc ttgccagaat ggggataggg ggcttttgtg agccaaaagt  22140 

tagtcggggg aatacttagc tccccctctt ctggtttttc tttctttttt ttaatttctc  22200 

tctctctctc tctctctctc tctctctctg ggcattggcc caagagtgag gccctaggct  22260 

tgggtatcta caatactaac agaagctctg tttttatgga caaaggaagt agaaaaggag  22320 

gcctttgtgg tctgaagagt gtagagggaa tccacatttt ttctctctct tttctgtcac  22380 

tgctttgtct cagaatctgc cctagtcagc tgctatgcca ggctgctaaa actccaagag  22440 

gaacctcata tttctggtga gaggaccttg cgagacaaaa ggagaagaat gtaagaggag  22500 

agagctagag aagaggatcc cctaattcta tgtatgaacc tatacaagtt ctgtgttcac  22560 

acctaaactg aacacgtgca gaacaaacac aaaatagcat agcaaaactg aatttcaatt  22620 

taaactactg ctaacatccc caaataatcc ctgagtattg taggtatagg acacagcaaa  22680 

gcctttgaaa acccagctga catggaacca gtactcatag aagatgagac cgaacttttg  22740 

acctgaacca aattggatcg attgccttct aaaacaaaaa aaaatcaaca ttccctaaag  22800 

gcttttaaca ggactcagtc tatgcaacat aatgttcaaa atgtcctaga taaaatccac  22860 

aattacacag tataaaagaa ctggaaaaat gtgaccaact tgcaagggaa aatataatca  22920 

acacctgcta actcctagat gaccaaaatg ttataataca gattttaaag caacaatcat  22980 

aactagagag tagttgaaca atttctctcc taaacataat catacttgca taaagacatt  23040 

tcagtcaatg atgaaccaca tatacaaagg tggtcccata agattacaat accatatttt  23100 

tactgtacct ttatatttag atacacaaat accactgcgt tacaactgcc tacagtattt  23160 

agtacaataa gatgtactaa atgcaggttt gtagtctagg agcaataggc tataccatat  23220 

agcctaggtg tgtagtaggc tatacctgct aggcctgtgt aagcacattc tatgatgttc  23280 

acacaacagc acaattgccg aaagtggcat ttctcagaac atatccctat cattaagtga  23340 

ggcatgactg tatatgctgt attctaaaaa aaattaatgc atttatatac cagaatctat  23400 

gcataagaat gctcatactg gtgttgtttg taataccaag cctgagaaac agaaggaata  23460 

aactgtcaca aaaccacaaa acggaatagt atcagtatac atcagtgcaa ataaaagaat  23520 

tacacctata cacttctaca tgcaactacc taggattaat ttagaagcat aatgaacaaa  23580 

aaaagagtac agaatcaact atgcttacac agctcataaa attaaacata catgtatgtt  23640 

aggttttgaa gggaaggcaa ggattaaaga aagagagggt ggcttaacaa caaatacagg  23700 

atttatgtcc agcataagac ctacagaggt gggagaccag cttaatgcca gtgcccgttg  23760 

cttcttacag gctggggtga tttataggcc tgggtgggag tggtctgggg ggccatggcc  23820 

tgcttcctgg gaacatgttg ataaggtgtt cccaggacga ggcggctctg gcccttgttc  23880 

cagtggaatg tggtactttc tcccagcaga gtataagagg cagcctgttt ctcacgcccg  23940 

aaccccgtgg aatgtttcac tttgactaag gtctgcaaaa tggcaggggg gcttacaaaa  24000 

atggtgcagt ttggactaac aacgtacata aatttttaaa aagcaaaaga ataaatccca  24060 

aatatgggaa agtgttatct gtggaagaaa gtaatgggat ggtatcagaa aagacactgg  24120 

taatttaaac agtgttgaca atgtctcagt tttaaaatta ccagctggtt cccatgtata  24180 

agttgcttac ttatctgtta cacctattta tgtatatata aaaataggtt tccaaacgac  24240 

atcccatgtg tatgaaataa cagaattttt atgccttatt aaaataattt ctctaaacac  24300 

ttgaagagcc cgagccgcct cttaccctaa acgaacccca cgcccctgaa ttgatcagtc  24360 

acttccgcct ccacctttcc agctccacct aaggaagcgg aagtacttta ctcttgggtc  24420 

ctcccacctg tagggggctc tccgaggctt ctagtgccac gaaggcctcc tgcctgggtt  24480 

gtccttatgg cgcctgtgag tttagttcta gaaaagatat ttgtatttta acttttccat  24540 

ctaacaaaca gtagcacagg catcttagtc tggacaacaa cgtacaagct gaattcctgg  24600 

ctagttccct cattatcaaa ccctgacaca gtagtaggcg cgagtcaggc agtgtgggga  24660 

cagccccgag ttgccgaaag tccccggccc gttttcctcc tgtgaagaca tagctgcggg  24720 

tggctgtgct ggtggcgttc aagatgtcga ccaagaattt ccgagtcagt gacggggact  24780 

ggatttgccc tgacaaaaag tgagttcaag aagggtcctg aattgggacg gagtttgtta  24840 

gtggaagctt tccgaggtcc gtccggcatt ttcctttttt atgattttct gtgccttaag  24900 

acgggttgag gcggcgaacc gccagttccc tggcgggaag aaggctccca atctcctcac  24960 

gagagaggtc tttccgggag cctttgttct agatatgtct tcagcgtttc ctcgacatta  25020 

cctccgcaag gtagcctctc tttttagagt gcgagatggc ctaccttttt gcccccaccc  25080 

ccctcccccg ccccggccag gttttagcga taggaaacct ctccagtcag gccagcttgg  25140 

tgttggatct cccccacgtg acttttctct gcagaacttt actcttgttc acggaaaata  25200 

ttgctttctc gcactcgtcc ttttgcctct tatagttcac cttgttttgt atttttactc  25260 

aaacttttcc tccatactat tttccccttt tccggaagct ctaccctctt cggtttggga  25320 

aattctgaca ttttctttgt ggatcatttc tccacaagaa ttgggctttt cgcctcctta  25380 

gagccgaaaa ggagggaaga ggcctgtgtt tttgcctact cagcccttaa gatgcctgca  25440 

gcagagaagc acgtgtgtta gtggctctgc tttttgacat tgttgccaaa gccagtactc  25500 

gactagatag ttaatcagat tttttttgaa gggtgcacaa ataggtgtat ctattcggaa  25560 

ataacatgga aaataattta atgtacaact catgttcaca taaaagcctt ttatttgttg  25620 

tacctaagtt agccacaaat aggttttgat tgtaaaaagc aaaaactttg aaataaacct  25680 

gggtttagtt aaaattctat tacttattta actgctaaaa aaggaataga attttttttt  25740 

taatgaaaac atgaaataac atggataggg tgtgtaaaca gtgacgtgta gcaaattcta  25800 

attggtggct attgatagta atttgatatt aagatgacct gaaggagtag ttcaagccta  25860 

acaaatgata ctgaatagaa ccaaagttat atgttatgga tagtattgct ctgagtggta  25920 

agacattatt gaaaacgttc aaaagattta gaacaacaac ttctgacttt gttgttacct  25980 

gtaaaataat gtgcttttgt cagtgtcttt aatgacagca cacccagagg taggactctc  26040 

aatgagagtt catttcaact catttacaaa tatatgaata gaatgttgtt tgtacaatat  26100 

gtttaaatgc aggataaatt ttcagagtat attttccatg cttaatggag ttaaaaggaa  26160 

tatttttagg ggaaaaactt aacctaaata ttatttagag tgtttcactt tagtgtcatc  26220 

ccatacttca catctgtatt gtattctagt ataatgcctt aaaaatcagc tttttaaagt  26280 

ttaagcattc catgttatcc agagcattta acatactttt accaatatac acgtacactt  26340 

ctaaggtcat gtgagtgaac cagtaattct ttaggtttga gtttgttgag tataagcata  26400 

aagtcttact gtactacatg tgttgagatt attggttttg gtggttgtgt catttttttc  26460 

agcgaagtct cagaggtttg agaaatgccc tgtaaaactc agttttctta caattattga  26520 

atctttttgt atttttagtc agtacaacct atcatatttg gttccttagc atcctaccta  26580 

ctgcatgtaa aaagataatt tcattaagat ccatgaagcc ctccttgatt tataagtttt  26640 

tttcctcatt ggtccaccgc tagggtttaa aactccctgg tagcttgtaa gtaattagtg  26700 

aagtggagtt aactctcact ttcaactttg taaagggatt ataactaatg atatgtgcta  26760 

atgtgaggac ttgaggcaga gatcctaagt aacttaatca agatcacatg actggtaaat  26820 

ggaggattgg gatatcttat tctgaatttg tggctccaat caagtatttt tcccccagta  26880 

aattgtgtgg agttttttgt tggtaacatt gacattaaca tgactaagat ggattagaag  26940 

ttatgaattc cagatatgta gtgaggacaa gttaaaatgt aaaattttac aaatttaaat  27000 

ttttataaat gctttttaat ctgtttttag atgtggaaat gtaaactttg ctagaagaac  27060 

cagctgtaat cgatgtggtc ggggtaagta tttaaagaag attctattta tactgtatat  27120 

gtatcattta tttatttctc caggttcata ttgcatgatt tttctgtttt cagagaaaac  27180 

aactgaggcc aagatgatga aagctggggg cactgaaata ggaaagacac ttgcagaaaa  27240 

gagccgaggc ctatttagtg ctaatgactg gcaatgtaaa acgtatgttt tttaaattat  27300 

tgtctgctct ttcttccaaa ataatagatc tggccactac ttgtttatat tacagctctt  27360 

attagtgaca ttgacaagcc agggtaacct tttaaatcca aggtattgtt attcagtctc  27420 

atctttaagt atagtataaa gaagttttaa attattcttt gcatttttta atggtaatag  27480 

ttgtcactat gatggattat gtataccagt aaacaaatgc ttatggtaag ctcaaaacca  27540 

atcggggggt ggtggtactt aaaagtacta aggcctatta cttcctttat tgaaaaatcc  27600 

caatttttag actgtatagt tagtgtgaaa tacaccacaa aactcatttt gcctgtttac  27660 

aaaataatgt tagattcata agttgtgtgc cgtaagtaat taagtctaat tataggtagg  27720 

tttcttaatg atttttattt tcaggcttag atttaattct tcattgattt ttccaacttc  27780 

catcttttct ctatgcagat gaatcctatg tgtatgaaag aggtctaaat caaaaaagta  27840 

ttaaataaat ttctcttttt gtttgtttgt attttttgtt tttgagatga ggtcccactc  27900 

agtcacccag gctggagtgc agtggggcga tctcagttca ctgtaacctc tacctcccag  27960 

gctcaagcaa tcctctcact tcagcctcct tagtaactgg gaccacaggc ccatgccacc  28020 

atgcctggct cattttttta tatttttggt agagacaggg ttttaccatg ttgcccagga  28080 

tggcctcgaa cacctgagct caagcattct gcctgccttg gcctcccaaa gtgctgggat  28140 

tacaggcgag gcatgggcca ctattcctga ccctagagtc ttaaataaat ttctgatcct  28200 

caggattata aatttgtatt ggaaaagttt ccagctacag atttggtcac tggatttggt  28260 

atgctttgga attcagtgct tgaactgaga cctcaaaaaa ataaattaat attatttata  28320 

gggtataacc atactcttta aggtatattc agagactgag aaattagtgg agctgttaat  28380 

ttaaagttat attttttcat aagacatcag aatttctata caggttcagt atcacttacc  28440 

tgaaatgttt gtgggttcag catccctaat ctgaaaatct gaaatgctcc tgtgagcgtt  28500 

tctgttgagt gtcatgtcct ctctcaaaaa gttttagatt ttggaacgtt tttggatttt  28560 

ggatttgtgg attagtgata ctcgacctgt ggttataatt tgtcatttac ttctcaaaat  28620 

gacagaggca cttttcatac tatataaatt ttgcttctct gcttaaatgg ttcagtccgt  28680 

tgttggaacc cacatttact cttcaggcca ctgtacattt tctttgttta cattaccact  28740 

taataaacat ttctttgaca gtggtttcat cctagttttt attttaaaat tgtaaaatat  28800 

ctaaaaattt gatattcatc tatattatag cctactaatt tagtattttt cacttctaaa  28860 

gttgcagcaa tgtgaattgg gccagaagat cagagtgtaa tatgtgtaat actccaaagt  28920 

atgctaaatt agaagaaaga acaggtatga taaaaccaca ttgtaactaa atgatttttt  28980 

ttaaagcact aaatattgaa acgataattg tatcaccttc gagtaagagc cacagtaagt  29040 

gaggattctg tttattctgc cctgaatgtt tgttactggg atttttttcc ccccatacac  29100 

acatacaaat cttttgtttc acaatttata aaataacagt gttagggacc tttatcctaa  29160 

caaggaggga cataagaata ctttcagaaa tattctcctc ctctcccttt cactggtttg  29220 

catgtttgtt attagtaatg atataatgat accattttta aattcttttg atagcctgct  29280 

gtgacttaaa gggcaaagcc acaccattta aagtgttctt ctaaagcttt ggcagtaatt  29340 

ctgaaactta agctatgtgc tagattatct gaaaaacttt ttcaaatatc gattgcaaaa  29400 

tgcagaactg ttaaagttat ttggcggtgg gtttccaaca tctgcaggtt ttttggatgg  29460 

tgtttgataa tcattggcct aaataatagt tgatcattgg ctttgtatgt tactggtgaa  29520 

atgaaaatgt ttacctaata gcatatagtt tttccattat caccaattag cccaaccaca  29580 

ttatctgttt acttaaaatc tgattttgtc tttcaactgc ttatatgtca catgatcaaa  29640 

ggattccttc tatatctagt caccctgtca gacttaggct tggtgaactg cttccctgtt  29700 

ttctttgcct ctctaacttt aggccgtttt cattgtctgt ttagtttcta gggatcagag  29760 

ggccactgtt caatcttttc gacctagctc ttccagactt caacagaaat tctactttta  29820 

tcccccccca cccctttttt aaaacttaca ttctcatatg tgagaacatt ataacataat  29880 

gtccttgatc cccccttccc cagcccaacc gccactttca accctcaaat cctgccttat  29940 

tcttaggaag tgattttgcc tttccaccga ttgggtaagt taaggccttc tgacaaggat  30000 

ctcgtttttt tcttccctca cctaaggtat gcaccgtacc tccttcaccg cccccaccaa  30060 

cccccgtttg attgattgtt tattctgtct cctttgcagg tttctcttct tttggccact  30120 

gatgttggga ttcttcgcag ccatccctgg ccctctttct ttcctctatt ttcatggtgt  30180 

tttcttctaa gcccaaagtt taagtaactt tgccatgata acccaagttt atgtctccag  30240 

ctcagacttc tttgacccat atatccagct gcctattcaa cattgccatg caaatgtcaa  30300 

actcattata ttcaaactga atttgtgatt ttacccctgg gacctgaccc tcttccaatg  30360 

atctctttct catgattagt accactcacc atacatttat tacataagct ggaaatctag  30420 

atgtccttct tagcctaaat agccctttct tgatatctcc cataccccaa aaattctttt  30480 

ccattaccac cctaggcaaa gaattactat gttttgtgga aaaatagcca cctagctggt  30540 

ttctacatgt ttttatttcc aaatttaaaa tcctttttta aaaaacccat tttgattgct  30600 

tttaggataa agtctaaaat ctttttaaca gtttcaaaac ttaaaaaaac tttgacctat  30660 

ttcctgactc ctttatagtt tcattatcac aagaactata gtttaacaga gaagtaagca  30720 

aattttattt gataacttct cacttttctt attgtcattt ttcagtcatt ctggtgtctt  30780 

gaacctttct cacttccctt gctacaagta tttgtctttg ctggtaacag ttgaaggtgt  30840 

gaaataactt actctgttgc tttccgcttt cttttggcta tttgtaataa agcagtgcag  30900 

ggtttgggga gcatttccta agcatgagac aggatatgaa taaaagagaa tgtgattcac  30960 

tacctctgaa agattgctgc tggcttatcc tgcataattc catcaaattg ttcagtaatt  31020 

tacttctctg tttcaggatt taggattatt tttgtttttg tcagcttttt tttaaaaaaa  31080 

aaaccattaa agataatggc ataaaaacaa acttagtaca ttgtgatttt tattcttttg  31140 

gattctttcc ttagaatatg ttctcaggag ttgaattaat tgttcagggt gtagaatcac  31200 

agagttttcc tgttagtgcc ttagttcttc ctttgaagta catgttatat tcatccccct  31260 

ttcccgcttt ttttccattg tcacaatctt gatccaaaca ttcattttaa acctgtgttt  31320 

gattctttct tggcccttgc tcagcttttt acattatact gtgagacaaa tttgaaaata  31380 

tattcattgt aagacttact aaaatctacg gaaattcttg gttgctttct aaagctttcc  31440 

atagaaattc aaattcatta gatgattcca gaattgtgtt ttctgtattc attccttgaa  31500 

gacatttata ggccactgtg caaggtgctg gggataccta ggtgagcaaa agagtcttac  31560 

agcaccaaag attaatgaag tcctctttag gaaagctatg cttaagctaa gaagtgaaag  31620 

atgagttacc tgagtaatgg attaaacact cttctttctg tttgtggaga agtaattagg  31680 

agaggtggcg gcaagagtgg aaataaaacc aatttataca gcattatctg aagtgcttga  31740 

aattagtaga atgacggaaa catacatatc attccattga ttccactatc tcaggtattc  31800 

agtgaaaatg gtatgcttca gttttttcac gatagggagc tagtgtattt tccatttata  31860 

cagagttaat gagctagatt tatattgtat gggttcatag aacataccaa tgtctttgtt  31920 

gtcagcagac tattttgctg cctcttaaaa taattttatt tacatacttt tgaaaaatta  31980 

actactagag ttatagttca ctttctaatt ttactatatt tttgagcttt ccatatttgt  32040 

catattactt ttcagttttt tcctatgtaa attatttcca atttagatcc cacgtatgtt  32100 

taaaaatatt tttattaact tccaagtatt ttgaagtttt cactagtaca aagtataatg  32160 

aagaaaagat gctatattag tgtgggtttt tttcagaaag tgaaatttta aaaatatttt  32220 

tttaaatatg ataggcaaat tttaagttac aagtcctaat ttttataaaa tatttttatt  32280 

ataaatctat ttaatatttt gctgatgaat gaagtcccta agtctggaaa tcaccggcct  32340 

tattgtactg atactgctct ggagtatgtg accagttaga ttgtattact cttgatcaac  32400 

acatacctct ttaattttca atgggagact ttttcaaaat atgtcaactc acttttccta  32460 

aaactagctc attttcttta attccagtct ctcctttaag cttatgtcag agacctgcca  32520 

attgaattgt atacattggt tgtgacatga gagaatagtg gtttgctaat ctcaactact  32580 

ttttaataga atcatttaat ttcaaaattt actggctact tcagagaacc tgtgtgactt  32640 

ttacctatgt gttaaaacca attaaaccag ggccaaagga tggcctttat tgtgttattg  32700 

tgtttgtctg tgtaattagg aattttccaa gctctaataa ggcctgctac attttaaagt  32760 

agcaaaattt cagaatatca gaagatttca gactatttgc agttggtaaa cagtggaatt  32820 

taatgcttgg ttgttactga gcccaccctt cccagaagaa ttacgattaa ctgtagagga  32880 

aagtccttta aaacttggtt atagcagaag tttgagatgt tttccaccaa tactttctat  32940 

gaattaaata agtcatgtag ggcaatttgg aattgaaaag agctagaagt acagccatat  33000 

gacgttacaa ctaagttctc tgtattttct gtggtgattt ctaatatgct ttctaaagac  33060 

tagtaattta ttagatgggt aggcagccat tgttgattag atgttttttg ttgtctggag  33120 

atttgggcat gatgtgttta ttatttaaat caattgtcat agggtaacaa tttgtgccct  33180 

cttttttaag gatatggtgg tggttttaat gaaagagaaa atgttgaata tatagaaaga  33240 

gaagaatctg atggtgaata tgatgaggta agctatattt tggtgttcag gttgaatata  33300 

aattagaaaa acagaaaaaa ttcttaaatg caaaggaaaa caaacttttt tttaagtgca  33360 

atttgagtct tcagcaactg atcattttca ggaaatcata aatatctaaa ataatttttt  33420 

agaaaatgta ttaagtttaa tgcattatca gctgacaagc attttgaaat tgtttttctc  33480 

tagtttggac gtaaaaagaa aaaatacaga gggaaagcag ttggtcctgc atctatatta  33540 

aaggaagttg aagataaaga atcagaggga gaagaagagg atgaggatga agatctttct  33600 

aaatataagt tagatgaggt gaacaatttt cttgtcctat ttcccttttg tcttattgga  33660 

gttataccat aacatgaatg cttttgacag cctcagacac ttggtgaaaa tatattctgt  33720 

gttttcattt gttctcacaa aggttttgga tttccactct gccaagtact atttgtactt  33780 

ggaacactac tgttctggag atacagtggt gaccgaaaca gaaccagttt tctcttacac  33840 

agttctagag gaggaaatat ataaataggt aattttgata gcagtaacgt tatgaagaca  33900 

catgatgtga taacagttta aaagcaactt tggttttgcc gatggataat gtctaaggag  33960 

gtgaagtttg agctgaaact tgaatgatag gaaggagcca gcaataagag ccgaggtgag  34020 

agcacattta ggcagagaac agcaaatacg ggttccctaa ataggagata agccagcagc  34080 

cttcaaaaat accatacata ggccagtata gttagagcag aggggagaat gagatgaggg  34140 

ggacagcaca catttcaggt ctggtgatac ttgttctgtc aggccagagt gtaagtttta  34200 

tgccatgtta agggtacctt agagcctgat cataagaggt cttggaatgc aactaaagaa  34260 

ataataagcc agttttgaag tttttaagaa aaaagtgaga tgtgtttatc tgtcctgtgt  34320 

ttcagagtga tgactgtcag tatattgaga tactagagag gcagaatgga tcttcagatt  34380 

tgaggagacc agctaagagg ttactataat atgctagaga ataaggaaca gagtgtctaa  34440 

gactaaaaat ggtgatttca aggactttta aggaggtgga cttgaaaatt cttgggtgat  34500 

gcataagtgt gacagaaaaa gtgtgtatgg cctccaggtt tatgtctgtg caatacctga  34560 

gacaaagttg tcaagtctct atttgagatg agtttagtag gtgaatttta gaattcagaa  34620 

ttaatttgct gagatacctg tgatatatgc atatggaggt gctcagtaca cctaactgtt  34680 

ttatctttcc tggtaggtaa cactaatatc taaatgtcta attataattg aatttttgtt  34740 

aggatgagga tgaagatgac gctgatctct caaaatataa tcttgatgcc agtgaagaag  34800 

aagatagtaa taaaaagaaa tctaatagac gaagtcgctc aaagtctcga tcttcacatt  34860 

cacgatcttc atcacgctca tcctccccct caagttcaag gtctaggtcc aggtaaacgg  34920 

gtacaggtca agggtaacac cagtcaaaat gtcagtatct aactttttta tttataaatt  34980 

ttgtttttct tgacgaaata aactttcctt tttattttaa aaatttaatt caaatcaact  35040 

tttaaaataa tttttcagct tagtaccata cagttgttgt ccagtatttt tagaaaagta  35100 

aagtcttagc atgaaacttc cttaacctat tttagcctca tgcttttgac taaaatagac  35160 

ttaaaaactg aattaaattt ttatatacac ttatatttaa ttaatctaaa gagatagctt  35220 

acatatagaa attaagtaaa ggggagatct gtattttcat tcaagatgtt aaaggctagc  35280 

acagaaattt tctaggcatt aaatcattgc ttattacata atgtttttaa tagtttgctt  35340 

tgatatcagt attgtgaata acggagcaaa ttcagccata ttagttctgt tgacttcatg  35400 

ctcataattt tgagaagtcc aggcgtaaac taaaactctt ttggtgtact tgaatattgt  35460 

ttgttgatgt aaaatatgta atctctgatt ttatagttaa caataaaaat aaaattttag  35520 

gtgagtgaaa gcagtgattt aaatttaaca gtgtcctctt gaaaaacctt aatcacagtt  35580 

aagtgatggc atgggcaatg aattttaatc atatttagga ataaaatact agatattagt  35640 

gtataacaat tagatatatg ttaattgagc actacaaagc ctgaaagctt aacaaagtgg  35700 

ggctataact agtaattttt tggtaaaaat atagtgatct ttttctacag ggtattatta  35760 

taagggacaa attatagttg taaattagat taatgaattt tgtgagtttt aaaatttgta  35820 

cgaaccatgt ctcccttgtg tcatattttc caataatata attacctaac aatgacagaa  35880 

ttatacattt tccctttaat tctctaagca ttgagtaaac agaaaaatat agggatgaaa  35940 

tacacacatg ccaacattca aaactttgta ctaactagaa acaaaaatag aaggggattt  36000 

ataaaggaaa atgatggaga cattttagag aaattaagta taaatcgcaa cattctgttt  36060 

tcttggatgt attctgggta gcttctagtt acttgtaaac aaagtattca ttgtttttgt  36120 

aataaagtga taatgttttg ttttatagtt gagtggcttt agggtaattt aatcacctgg  36180 

aaagtgatat ttttttaatt accttttgtt actaaatctt atctaattta aaatactatg  36240 

ttttgaaagt atatatcttg tatagttatc tttttatatg aaaatgaact ctaatacata  36300 

tctttctttc agtgttcata tcacaaagct caattaaatg gtcctggaaa aaaaaaatcg  36360 

ttccatgttg ttccaggtcc cgttcaagaa gttcttccag ttcgcagtca agatctcgtt  36420 

ccagttccag agaacgttcg agatctcgtg ggtcgaaatc aaggtgaatg aggtagcatc  36480 

tctctgtaaa gcagagagaa aaatatttaa aggctgcaga aggtgttgct gctttttttc  36540 

cccttatttt gcttctactt gtcgatttta ttttagcatt agaaaactaa tgcacttgcc  36600 

tcagcttaat tttctcacca tgaaatgttt ccattgccag cagtgtgcca agacattccc  36660 

atgattgaaa tcaggtggct attttgcaat atgcagcgtt tattattttg gcactaagat  36720 

gttatgaagt aggaagatga agccaagtct tatcgccaca tctctagtat attaagatta  36780 

tatatggcca ggcacagtga ttcatgccta taatcccagc actttgggaa gctgaggtgg  36840 

gaggatcact tgaggccagg agttcaaggt tgtagtgaac cttgatcaca gcactgtaat  36900 

ccagcctggg tgacagagga gtgtctcaaa aaaaaaaaaa attaatagta gttcaaataa  36960 

aattacatat gtaaataaaa agaaaaattt tcttcattat taaaaggaag aaaaataacc  37020 

ctgcctcaaa acaggtcctg ttttgcacgg cagttgtttc aatattttca gaaacaaatt  37080 

tgccatttat atcagataaa gttactagag tactgtatat acattttcct ttctaatttt  37140 

acacacgcta ttatttatag agcacaaaac actcaaaact aaatcaggaa gtatagtcgg  37200 

ttagttgaga taggatgtgg tcttaagtag taaacagtgt tctaaagttt caggttgcat  37260 

gtagtcacat ctgtagaggg aaacataatt tgaaagatgc tcttgcagga aatttttctt  37320 

tgtttagtca aaatatgctc tctttgtttt taagttaatt tattatgacc taaaggcatc  37380 

taaaaaataa ataagaaaat gaaattccat atttgtggaa attcatattg aagtctaact  37440 

gtggctgttt tggtaaaagt atttgctgct ttgaatcaaa tttagcatta aagggctgcc  37500 

acagtataat catgttaagg agaaaagaat gttgtgcaca cttgcattat aagccaataa  37560 

gaaatagata acaaggccag gctcagtggc tcacgcctgt aatcccaata ccttgggagg  37620 

ccaaggtggg cgggctgctt gagcccagga gttcaagacc agcctgggca atatagtgag  37680 

acctcgtcta ctaaaaataa aaattaaaac aaccagccag gcatggtggt gtgttcttat  37740 

aggctgaggt ggaaggatca ctggagccct ggagattaag ggtgcagtga gccatgctta  37800 

tgctactgca ccacagcctg gggaacagag caagatcctg tctcaaaaaa aaaaaaaaaa  37860 

atagaagtag agagcaaatt attttttatt gttaccatta tttagtaaca atatttaagc  37920 

gctttatagg taaaaatcct taagttctgg tattcccttt gggaaccatt ataattaagg  37980 

tttacagaac acccatcata ttcttcccaa acattttttc attgcttgta actttccaaa  38040 

gaattctcct tttgggcttt ctggttttat tttaagccca aaggtgaatt ttttgggaag  38100 

tttgagctaa attccttcaa ccaaaatata caagtgaaga aaaaaaattt gtatttaaac  38160 

atttgcacat ttacttctac ctgaagcatg tgaatgtcaa cacttcatat ttcataagta  38220 

gtgggttttc ataaaaatag tattgtaaat ataaatcatc ttaaagttag tttttatttc  38280 

ttcttgaata tttagcagtt aagtacagtt actagtcttt tgttgctgtg ccatatacct  38340 

ggtttttcca taacagttta atgagttgaa taattccaca tggaattatg tttattttcc  38400 

tcaggaagtg gtatataaga tacatatttt aatcctcaaa tggaaggatg tagttcctaa  38460 

acgtaaagtc ctgttaatgc agttatctgc tgattttata atactataat atttgtgtat  38520 

actttgaaaa gccttaaaaa aagtttaaat tctattttga tatagtaagc agggttttaa  38580 

ttacacatga tagaatttta aagagacaaa attaaaatgt ttaagtagaa tgttttcatg  38640 

gttgatccag aagtcttctg ttgaataagc agtaagtatt cttccttata aaattttcat  38700 

agttgttata aatcctgttt atttttggag ctatctgata actaaataat cttccttatt  38760 

tcttctttta atgaaatgtt tgatttgttt ctcaatcaat gaagatccag ctccaggtcc  38820 

cacaggggct cttcttcccc acgaaaaaga tcttattcaa gttcatcatc ttctcctgag  38880 

aggaacagaa agagaagtcg ttctagatct tcttcatctg gtgatcgcaa aaaaagacga  38940 

acaagatcac ggtcacccga aaggtttggg tttctgtaga aataagaatg ggtgttctta  39000 

agtgtgttta atagataaag taaactttcc tagtcaaggg ttagattttt attatctctt  39060 

gtgttccgac tttctacttt tcaactttga acttcaaaaa aacattactt tgcttatcct  39120 

ttgtactttg atcaggttgt ttagaattgt agatcaaacc attctttgat cattttattg  39180 

tttaaatttt tagttccatt tataattttt atagccaact ctcggttatt tctgtctttt  39240 

gagattgcaa ttcagaagct gtatgtcgaa gtaatttatg agttgacttt tatacttagg  39300 

cttctttaaa tactaatagt caagaattct agagcatcta ataaaaaatt aactttcaga  39360 

tcattgggaa tctgtcctca tttaaatatg tgtaaatgca tttccacagc aaattgcttc  39420 

atgccctttg tctataagga aattattcct tgtagctaat acatttttca ttttgcagtc  39480 

caaatctttt ttgagaaagg cctatattag gttactttat ctgtactgac acttttaata  39540 

ttggaagaat gcaactgtca tctgtcagcc ttttctgcaa caggctaatt actcagtttc  39600 

attaattttc tctttgttcc caattatata gtcattttaa tggctttatt tgtagtcttt  39660 

gcaaattttt catattttat tagcttgtga aaataaagat tatgtaaagt ctattaattg  39720 

ctgggttcag tggtaggatt atctcatgat tcctacttgt acagaatgat tagttttgct  39780 

tcttcacatt ttggagttta gatgttaaga tttcacacag tcttgtttct ctgcatttgt  39840 

ttctttgtaa aaaaaattac tctgtttttg agtggaattc attctgttgc tttcttacca  39900 

cttctgcaaa tttttatctt agccacatat aatcccccta gtttgttgtc atctaaactt  39960 

aatgaacatg ttctctattc cataagccag gtgattggtg aaaacactaa acaaccctga  40020 

gcccagggcc aacccctacg gaacaccact actttaccca ggttgatatt gacttattca  40080 

tactagctgc atgaatataa ccctatagca aattgtacaa tcatcttgtg tgacctagat  40140 

ttccaaaact tatttatgag tatattttct catacacaga agccttgctg tatctttttt  40200 

acataataga cttcttacac tttctacacc gtgtcacagg gattggttta gtcacacttc  40260 

cattaccaag tttatatgct tttgttgtac attttctgta attttacaca tttttgcaag  40320 

gcttttcttt gatatcttaa ataattgaga ggtggctata ttttgaaatg agattctttt  40380 

gaaattgtag agaatttttt attgtattta tatgataact gggctcatat ccaaagtcta  40440 

aacatcagat aattttatgt gtgtaagttc ctatctcaat ttttaatttt tttgctagca  40500 

tcatggtact gaattttgta tactttcaca gtcttaagaa tgaatgctga gatttagctc  40560 

tagcttacta gaatgcctac tctctccatt atgtcttaca gacgccacag gtcatcatct  40620 

ggatcatccc attctggttc ccgttcaagt tcaaaaaaga aataatgtat taaaatttac  40680 

atcttaaaaa aatccagtac agtgcatgaa gcatattttt aaagaagttg gtgtcttact  40740 

tggtcagaag tgctaaatct gctagtagag gtgcatgcct ttcattgctt ttcaaaacaa  40800 

tacagctgtg tttatttgtg aagttaaaag taaatagcat tttaagccat aatgtcccaa  40860 

aatagatgtt ctgtcattca ttatttacaa ccatttgctt catttaaaac catttcagct  40920 

ataacaaagt actttgcttc ctaatttaaa cccatttttg tcatttccaa atacatcctg  40980 

tccattggct aagacaggat tacctaggct tgcctgaact ttgggcatgg aagaaagact  41040 

ggaaactagt tggaaacaac atacttatgg aaaagaaagt cagccttttt atgctgttaa  41100 

cagatgtcag agtgattctc accaaaaaaa gttaaactat gttgtaagca gccaactgta  41160 

aatgtctatt ttgaaattcc ctatgctaag ggtgccttag aatcattgtg tctcttttat  41220 

ccagctttac ttttttgctc cacatttaat gcaaaagaat cttgtgatgt ctacaaggag  41280 

agaagtggga tatattttcc tttctgacac ataatttggg gcaaaaaaga aagtcttaag  41340 

agtttatctt ttctctgctg atacggttgc ttgataaaga catctcaaaa tgtttaccaa  41400 

tgttttaaga agctttgtgt gatattcttc caaatgtagt taccaaatat aatatggtag  41460 

aaaaggctaa atcatactta atgagcaaat tgaagtaagc ttttaaagta tatttctctt  41520 

ttggtgaaag gccaatggag acattgtgaa tttaagtgaa catttgcctc aagatgttaa  41580 

ctataaacac actgcataca attttcttct gaataacaaa tgaatgctta ttgctgcatg  41640 

atgtaagcaa aagtcattat ttttcctatt catttgaaat aagttatggc ttaaaatgct  41700 

tttggagttt atttctcaaa attaaaatct ggtcacatga gctttagttt gttttctggt  41760 

ttaaaaaata aaaaggtttc tcttaacagt atttccagtg acaatgcaag gtaagtatat  41820 

caaaggaaat caacagttgt gcttgggggc tttttgttat gggatattga tttcttgttt  41880 

tttttccgta acattgtctg ctgcaattta aataaaaatt acgacatttt aagatatttc  41940 

atagacaaac caaacaaaaa tatatgtttt tactttaaag tgaatgtttt tctcttcagc  42000 

tgatctaaaa atgaaagcaa gatatcttat gtagaaatat tttgataata tttttacagt  42060 

gagctttccc atgtttttat gtcttaagtt tctttgctgc gtttatgtag gttgcacaag  42120 

aacttttact cacttgtaat tgtgcctcag actttttgaa agtctacctt ctaaattgcc  42180 

ccgacgatct agattctaca tgttaccatt ggtttattct tgtgctttct gtatttaaaa  42240 

ctttggctgt actaagcaaa tgcaaggtta taatttagct aatagtagtt tacagacaat  42300 

tctgatgatt atgatttcat ttggtttaac taagctgtac tagttcattt cataaggaaa  42360 

tgatactgta gacaaatgta aataaagcct gtgagtcaag catcaagtgg tgtttgttag  42420 

aaataaacta gagattttta aactctgatc taatgttcat ttttaaacta attacagttt  42480 

tctgttacct ttgatttgtt aattttttac actctttata ttcacctacc ttttatatat  42540 

gagtgcttgg tattttaaat tccaaagcca ttatcactgc aacctcagaa tttttaattt  42600 

aacctttttt tcgttttaaa tagagagctc ctaaattagt tgcacacttc ttgccagaac  42660 

attacatccc tcattccatg tggtaaaata ccatatcgta gtgtgcttcc tgaattactc  42720 

ttaaactgtc accttatata aagcactcaa ctgtcagctt aacagctaag ttttcttaag  42780 

tttctatttg gagtcctttc atctaaacaa tattgaatga tatctggtaa taaatgtcca  42840 

agttcagaac tagatctaaa tagaagatca tctctaggca caattaccaa gctaaattag  42900 

atctctgaaa ccatgtcatc tccccttctt gctatcttgt gtacatagcc agtgttgtgg  42960 

atgttggtaa gaaggtaggg aatttctcca ctttgccccc tgtttttgac ataaggttta  43020 

aatgtttttt aaatagaaat accctcatgg ctttcctgac ctggaaatgg tatttctatt  43080 

tctggggaaa ttgagtagac aggtttaact aaaagacagt ttcgtgtgtg tgtgtgtgtg  43140 

tgtgtgtgtg tgtgagagag agagagagat ttgcaggcat tatctaattc tccctatgat  43200 

cttgtgagag tatatactct tgcatatctt gtgttttgcg aaaaggaggg ttaaagcacg  43260 

gggaaattaa aaacttgccc aaggaagcca caggaatagc aaagtaggga ttcaccccca  43320 

aacatgatgg gaaatttcag tattatgtgt aataaaagcc aaaactcttt tgagaaaata  43380 

aatgtgaaat tgttaagccc gatagtcaga tattttttag tctggtaatt tggtagagaa  43440 

tatataattt cagccaatta tagtcaggga ggttagacaa acactatttt ggataacttt  43500 

agatttaaag aaaagttgca aagattgtgc agacagttct catatatccc cactaatttt  43560 

ctacagtcat tagcatctta aattgccatg tgtgtatatt tctcaaaacc aaaaccagcg  43620 

ttggtatgtt actattaatt acattacaga ttttactaga atgttatcat ttttcccctt  43680 

aagatattcc ataatctaga gtaccatctt gtactactaa taccttcctg ctctcttctc  43740 

ctctatgaca gtttttcatt ctttcctcat ttttgatgat tttgacaatc ttaagagagt  43800 

actagccagg tatcctctag aatatccacc actgcattct gtatttgact ggtttttctc  43860 

acgattagac tgggattatg gggttttgca gagaatacca cagaggaaaa gtgtctttct  43920 

tgtcacttcc tacacagagg aaaagtgtct ttcttgtcac ttcctgtgca gggtacatca  43980 

taaccctgtg acttcactgg gaatgttaac attcgtcatt tggttaaggt agggtttgcc  44040 

ctgattcacc attgcagtta ctgtttctcc ttttacctac tgttactctt tcaaatcagg  44100 

ttatactaag tgtagtccat catcatgata agacggggga attaagttcc atatcctttt  44160 

ggggttaggt atctacacag tatttggaat ttttctataa gaaagatttg tctccatttc  44220 

ttttatatat atactcagtt atatttattt tatacttgtt acttattttt catattggct  44280 

tttgtgacct ttgacaagcc tttattctct gttagagggg aaagtagatg gagagaggga  44340 

gggaagaatt tttggagagg tatcaaatag gagaaaacat ggggtctaga gccatgacaa  44400 

ggcggtgggg ggtgccttca atattaaatg agagcctcca cagttaatta cagtatgagg  44460 

agggatgggt ccagattgca ttacagccaa atttgtagtc attgagagtg agcagtaaac  44520 

atttaatggt tttttttttt cccctcagcc acatcgaact acctggctgc ttgaataagg  44580 

gtgttgtaat attacacaca gatataaata ataaacatgt agtaatagtt cttaaatatt  44640 

tgtttagcaa aataaaaggt gctgggataa gaaaaatgtt aacattaact tggtaaattt  44700 

gaaatacttc aatgcagatt aaaaggtatc taaaaagatt ttgaggaaag ctacacaatt  44760 

tttttcaaag aaaaatacct aaatttgaag ctaaaaatgc ataggacaac tcctcccctt  44820 

aacctcaatt tagtgcgaga aaagctctta taaaatacag ttgtacttaa gtgtctgtgg  44880 

ggaattggtt ccaggatcac ccacagataa caaaatttca agggtgctcg cgttccttat  44940 

gtaaaacagc atggtatttg catgtaacct atgtatatcc tctcatatac tttaaatcat  45000 

ctctagagta accctaatac agtgccatac attacttcac gtagattcag cataacacca  45060 

tgtggcaaat tcaagtattg tctttgggac tttatagggt tttcttttcc cctgaatatt  45120 

tttaatttgc agttgttgaa tccatggatg ctggatacag aactcatgaa tatagagggc  45180 

ctgttcttca ggttagagat aaagcctcca ataaaatagg aacagttttg cccgaataaa  45240 

gaggcaaact cttaatgagt tgacttgcag tcttgaagga caaatttata gatgaataag  45300 

gcaagctaag gttattctct ttgcaacact gaagatttga cgtttttagg gaactaaaaa  45360 

taccatggct gtgggaaacc tcggagaagg acagggaact tcgtaataat gctgttggaa  45420 

ttaaactgga ccacagtgaa tactgactac agaatattga taatttgaat agctaagtgt  45480 

tgaacacaga acagtgggat tttgcaccta ccctaaaatg aaacatctgt gacctgttat  45540 

tggtgaggtt atcacaaagg ctaagtacct ccaacctaaa agtaatagga actaaagttt  45600 

actttaatgg gtgtgatgca gtggtagagt tgtgactgat atttggttac tatctggttc  45660 

ttccactgac ttcaatttag ttaatggtaa ctgagtgact cgagacattc tttatgccta  45720 

agttgttaac acctataaaa tgaaaatgac cgtttctacc ttgtgggaat tattataaat  45780 

aatgtagcat atatgtatgc agcaaatatt ggcagttttt atcccttctc catgtttaca  45840 

gatatttctc atatatacac acacatgcac atatatatgt gtatatatgt ttatatatac  45900 

atatatttgt ttatacatat atatgtttat atatacatat atttgtttat acatatatat  45960 

gtttatatat acattatata tataataata tatatgtata tatatatgca tgtgtgtgta  46020 

tatattctca gatgcctatt tcccacttac tctttctaga gcaccagatc catgtatcta  46080 

gctgcctcct gtgtatctcc ctttattttt tttctttttg tcacgatgag tcttgcggtg  46140 

ttgcacaggc tggtctcgaa ttcctggact caagcagtct tcctgtcttg gcctcccaaa  46200 

gtgctaggat tataggtgtg agccactacg cctggcctgt atctcccttc acatgtcaga  46260 

cagccaattt tactgtattt aaattcttcc taaatcctct attcaccaaa cctgtatctc  46320 

atgttgtatt tcatattgat aaacatcatt atcagtactt gataatcctc ttagatttcc  46380 

tttttgtgaa cactaccact gctttgattt gtgggctagg atattgtagt ttcttcctaa  46440 

atggtcattt ggcatttagt aggatttcag taatatttgc taaatgaatt tttttcacca  46500 

agcattgatc acttcatcac tgatgctaga atgctcttaa ctaacgagca tttcatttca  46560 

tgttatttct ttgtttaaac cctttcagtg ccttttcatg gctttcagaa ttcaactaca  46620 

atccttatgc atatagtaaa aagttcaggg gttttttcca ggactcacac tacccccacc  46680 

tcccaattct aacctactta ggtgcacaga acctatacac tagctacgtt aactatgctg  46740 

aactactaat aggctttcat cttagtacaa gtttcttata cctgggatac cctacacata  46800 

ccccactacc atttcttttt tcatttagct ttcatgactc aattcagaac actaggatgc  46860 

catccctgat gcctcttccc tttcaatggg aattgggtga aactcctaaa agtttctcct  46920 

tccccagtat ccctctccct tagcatagtg tttgtcatta tagcaagcac tcaaatgttt  46980 

gatgagggtc aatatctgtt acctttctca aagaggtttt gatcagttgt attttttcct  47040 

cattactgat agaataaatg ttcttcgctg gaaagcattc tttgattgtg aaaggagttt  47100 

ttattctgaa attaaagctt tgtaagacca ttgtaggaga aacttttctt ttttcttttt  47160 

aaatatttat tttagagaca ggtctcacta tgttggccag gctggtctta aactcctaac  47220 

cttaagtgat cctcctccag cctcccaaag tgcggggatt ataggcatga accaccatgc  47280 

ccagcttttt tctgtttctt aagtccaagg aggccatttc ttcataagct gaaaaaactt  47340 

tgaagttatc tgtccagcca tccttcagga gagggtagaa catgtaaata aaccttattg  47400 

tcctcaattt tctacttaaa gtatgccaac ttatatttta ttacacacaa ctaagatagg  47460 

ttgagaaaga gcagcctcac tggcatacat tttgaaatta gattatttgt atatcaccaa  47520 

ggacagaagc acaaaaaatt actatgctgg aagtaagact tggggtcaac tattggcttt  47580 

cttcctaaca tgctgtgtga tcctctgcaa aaatattaac ctaagggact tcactatgga  47640 

ttggtaaatt gagttcccta taaatgtatg atcctgaagt aagtgcattg gggtgcatca  47700 

ttggcaaaat aagcaacaaa tcaaaaagta atttacctaa cttggaggag cagatgatag  47760 

agttcaaaat gctttgttag gttaaaatac tacgaacagg catatcatgt actaggtaga  47820 

accgaatttt ataagtatag ttaaaaagct ttcaaacaag aaaatataaa atacattatt  47880 

gcttgataac tagaccagta gatttttact gataaattgt ttggacattt attttggctt  47940 

atatacataa cactaactgt aaatgagcta tttctgtgaa aacacctaaa agtcaaaact  48000 

aaaatggaag tgttcagttt ggatgaagca aatccagtta attatggtct atcctcgtat  48060 

taactcttag tgacactgtt acctctaatc tagctgttga ctgtgaacct gtcaaaaatg  48120 

ttgctttttc agcaattatt tccatgtatc aaaattctga tcagggaaaa caagttatct  48180 

gtattcttat aatttgaata atgtattaga gcctaagaat tttaatgtgg tatcagcaac  48240 

tgtgacacaa gattgtgttg ccctatatca cactcacaat tatgtctcct gttccttatt  48300 

attgattcct tagaatcaca aaaagggaaa ggttaaggag aatgtagtta attctaccag  48360 

aagaaactac ctcagtattc tcaggctgca cccatagtac ctgtggcact aaaatcttag  48420 

gatagaagag tgctaagaag gaagaaagaa taataaaaat aatgttttgt gttttttcct  48480 

catattagtg ataatgaaaa tgtgtttaaa ttcaggcctc ccataaagta ttgcgtatca  48540 

taaagtctaa ggcaggtacc tgaccgtgaa aaactacatt ttgaagcact gatgactgat  48600 

aagagagaca caaaatgttt aacctgtaat tttggtgaag ccattggaaa ttagcaaacc  48660 

tacactatgt tttctctaca tttggagact attcatctgt taatgtagat gcaaaagaaa  48720 

gtcttattca aggactccaa agacatattt aacacaatat taaacattga acctgcattt  48780 

taagcaccac tgcattctgg tatcattgct tagtgccctt ttgattatat ttgctggggc  48840 

tatttgaatc agtatgatct atttttgtaa aatccttaat ttttttaatt agaggataag  48900 

ttagcacggg ccttttagag ggtaatttga gagtatctga aaaattagag tattcacagt  48960 

atgaacattt aaacatacta atgaattacg ttactgcatg ctaggtagtg aactaacatg  49020 

agataccttg attgaagcaa ggagaacaat tccgattgct actgtgaagg atataaaagg  49080 

ggttggtgta taaaactact cttaggacag taagtataag accttggggt caggcaaatt  49140 

gtacttggta actgaatttt taagagttca gtgccgcggg gctaagtctg ctcctggata  49200 

tgatgagaag ccagtaaatg gcttgggaaa aaaatggtct aagacagagt tgtagagtta  49260 

gaggacctgt catacaaacc ttgtaagcca tagaagggaa tttacatggt atgcgaagaa  49320 

cagttggaaa atagtaaaca gtttgaagtg acctagtttt aatacaaatt ggccactgct  49380 

tggagaatag atcagaaaga accctactgg atgggaaggg aatagtaaga agtcttactt  49440 

aagcaaatta aagttattac aaatttatat gatcaaaaca ctaaatttta gggtaactac  49500 

atgacagacc aatagtgttt taagaagttt aaaatgtgga aattcaaaag tggaagtagg  49560 

taatttgagc tgttgtgaga ttcattcctc agtaaatggt aaaagtacta tttaagtaga  49620 

ctctaataaa tcatggaacc atattttaat ctccataacc actaagaata ataaaggtat  49680 

aacaagtagt ggggaaaaag ggagtaatga aaatgattaa tacaaattag ttttttaaga  49740 

ggtaaagaat gacaaaacag caagccagtt aaactctcgt acctagaggt ggattataca  49800 

ccaattaatc cagagtatca gacagggtta agataaattg acaaagccaa ttgtgtattt  49860 

gtaatatgta ttttcagttt ggaaataaga gaatggggaa agtaaaagtt tggaattaaa  49920 

catccccatg ggtcagcaaa tagtgggatt tttttttgaa tgaaaataca atttatcagg  49980 

ccgggtgctg tggctcacgc ctgtaatccc agcactttga gaggcgaggc ggatggatca  50040 

cgaggtcagg agatgaagac catcgtggct aacacggtga aaccccgtct ctactaaaaa  50100 

cacaaaaaag ccaggcgtgg tggcacgcgc tgtagtccca gctgctcggg aggctgaggc  50160 

aagagaatcc cttgaacccg ggaggcggag atttcagtga gccgaggtcg caccattgca  50220 

ctccagcctc tgtgacagag cgagactctg cctcaaaaaa taaaaaaaga aagaaaaaag  50280 

aaaatacaat ttgtcaacac ctgtgagatt gagctaaagc agtgcttgga gttgtgtaac  50340 

tttgaaagcc tacattagag aaaattaagt caattaaact ttcaagaata caggaaaata  50400 

ctggcagatc aaacgtaatt cagagaaaaa aagagcagag gacttctgct tcaggccaag  50460 

atttaccctt caacctgtaa caaactagac aaaatgtatc aagcagcatt tttcagtaca  50520 

ttgaatgtaa ggctgtggag aagtacctga gaaaggaaaa caaggtgagt cctattaatg  50580 

cttcccagac tggccagatt ttctcacagc agccagccct atctcacatg tattaatgtt  50640 

ataatttcac atactctata atgctatcct ttgattagcg tttagtttga tgggaactcc  50700 

aaaccattaa agaaaattca ggccagccgt ggtggcgccg tgcctgtgga cccagctact  50760 

caggaggctg aaatgggagg atggctcaaa cccgagcagt caagtgagcc gttattgtgc  50820 

cactgcactc cagcctgggc tgtaacagag caagaccccc atctctaaag cagaaaagaa  50880 

aaaaaaaaaa tcatagcagg tgctacattt gcactgagaa gaatccacaa gcagagatgt  50940 

ttgtgagaac agtggtgtct tcagcagcat cagttcccgc agactcgagt gaattgggct  51000 

ccggcatgtg caccacgtgg ggtccagagt gcctggcccc agaacagccg ctgagtgcag  51060 

ggaccctaag gacaggggtg ggggtctggg tgacaaggcc ggaggagtcc ctggcacccc  51120 

tcacccaccc cgcgggacac cccagttgac accgtgtgcc agcaaagttg ggacctgatg  51180 

gttttgggaa cgtaggtcat tgaaagtggc ctgcagcaca cagcctgtag ggagcaggca  51240 

aggagggtcc ttgtccatct acctcctgag gctgtccttc ccgtggccat gccacctagg  51300 

caggagtgcg taggacttgc ctggctggaa cccacccttg aaaaccgcct gaggaggtgc  51360 

cagagtgtgg ctgcgggctc cagaccacgt cggctccacc tgcccggaac ccagctgcca  51420 

ctagcgctgg ctgggaacac aggcttgctg tcttctccgg gtcttgggaa acctgtactt  51480 

cttaagactc attcaggatc agcatgtcca tcccaaggac ttcttcagga aaggcactcc  51540 

ctccccacta aaagaacgtt cctcaaagca atttgagaag cgcagcccat ccgcctccag  51600 

ctgggtggcc gcagacacat caggctccgg cctccctgta ttttcatgcc ccacagtgaa  51660 

aaacgtgggc atttctttcc agttatgtcc ttagccaaat gcggagcttt tctgcccagg  51720 

atgggcaaaa ttctagcact ggcaggggtg caacccaagg ggtggccggg gttctcactg  51780 

cccttggcca tggggcaggc tggtctagac agcaggggga tgttttcagg gttggagttt  51840 

ccccccacct agtcctgaac ctattgggtc atggagcacc tgtgttccca tgaggccagt  51900 

gtgggccaca catgacttca aacggccctt gaggcttgat taagtgtgcc agtttcattc  51960 

caaacatgct gctctaaagc atccctgctg agccacagga ggatcagata ctgtgagctt  52020 

ctggcctgtt gatactcaag agccagggca tgcggggaag actccagaag tcctaactct  52080 

tgctaacctt acatctggga ttcttccacc ctcagctgaa gaacttgatg aatttcaact  52140 

ttgaagagat tcttctaaca cttggccatt tcaaccaggc tttgctaaag tcctctgaaa  52200 

ttgggggact gaaagccaat tacttagatc acaggttgcc tgtgaaatct gcaaggacct  52260 

gctgtcaggg ctcattaaac cccaaagtat ggcccctttg gcatgtggac tactctgacc  52320 

cagaggagac tggaagatct cagaagccta gcctttgtcc ttccctcctg gttcctgtgc  52380 

ccttttctcc cacaaagtga gtcacagaaa ccagaatttg ttttccccaa ggcaggtcat  52440 

agaaactaga actcctctct cccaaacata gccataaaac ctagcaaggt cactctgtcc  52500 

cttctccctg gaaaacccct cattcccgag gggtcctgcc ccatacccag gggaagggga  52560 

attgtacaaa gcaaccttgt tgggtttccc cactccgtcc atcactgtta ggccacgtta  52620 

gcgtgggtga cagagtgaga ctgtctcttt aaaacaaata aaacaataga atttctgtgc  52680 

ctactaacta aaagagataa tcacacgttg ttcaatacaa caacagcaac aacaaagctg  52740 

taggagtact tgcagtaatg atagaggaga aaagatgtca caaggaaaaa tcctctttta  52800 

atctcagagg tttatagttt taacaggtac atttaagtct attatctatt ttgttttgtg  52860 

gtgtaaggtc tatgttcatt tttatatcca tacagctatc tagtttttcc agcaccactt  52920 

gttaaaaaga ctgttctcct gaatcacctt aacacttttg acaaaaatct gttgaatgtc  52980 

tgcatatgtg tacacatatc tatatctcta tatgtgtata tatgatgctc tctataatac  53040 

tctctttcat tgatctatag atcagtgtct tagtttgttt tgtgctacta taacagtact  53100 

acatctgggt aatttataaa gaatataaat ttatttctca atgttttgga tgttggggat  53160 

gttcaaaagc aaggcgccat catctggtct ctggtgaagg ccttcttgcc ctgtcctcac  53220 

atgtcaggat gacaagaaag ggaccaaact ccctctgtca agcccttttg taagagcagc  53280 

taatcccatt ccctcaagag atgtcctcat agcccaacca cctcttaaag gcgtcacctc  53340 

ttaataccat catagtagcc attaagtttc aacacgaatt ttggagaaga cacattcaaa  53400 

ccatagcatg cctatcttta tgccagtatc acgctgccct gcatataaca atagtaaaat  53460 

atagttaaat ttgtaaaaac aagtatttga attttattaa actattgcat tggaaggcat  53520 

tcaaaagcat acagaaatca tagaagagaa aaaaagacct gcaaatgaaa ggagtaaaaa  53580 

ttatgactta ctggtttttg ggatcgagga tcctgcccat tcttcatgac tatggctatg  53640 

ggaaatactg gtagaaaaaa aaaaatcata gccttactgg caaaaagttc cagagactgg  53700 

agttaaggct tgaaaagcca ctgcaaattt aagtaggaaa tcttggtaat gagaaccaga  53760 

gaagaaatga gatagaacta cccaaattca tgtctcacag caaactctgc atgagtgaag  53820 

gagaccacat gaagcctgag gaaaaagcaa gcaaagacca gatagaaatc tagtcccagc  53880 

actttgggag gtcaaagtgg gaggatcatg atgttaggaa atcgagacca tcctggctaa  53940 

catggtgaaa ccctgtctct actaaaaata caaaaaatta gccaggcgtg gtggtgggcg  54000 

cctgtagtcc cagctacttg ggaggctgag gcaggagaat ggcgagaatc tgggaagcgg  54060 

cgcttgcagt gagccaagat tgcaccactg catccaacct ggatgacaga gtgagactcc  54120 

gtctaaaaaa aaaaaaaaaa aaaaaaaaaa acaaaacaca cacaaaaacc attattcaag  54180 

aatacatcta ctttgattac tttgatgctt tacttaaggg gatgtattcc tccctgtgct  54240 

gtgtgtactt tgggtgggag aaagctgaag cttcagaaac tttaaatgtc agggaatagc  54300 

cctaagctgg cagagtagct gcaaataaga ggagaatccc tagaatcaag gaacccacac  54360 

agaaggtgat ctccattgct aactgaccag caaattacac aggcataggg aaatcaatct  54420 

ctaggaagcc aagctaaaag agcatggaaa accatgagaa tgaagcagag ataccaagag  54480 

cagcatgccc catgggaggc aatattggca gtttgaatcc ggacaagtta actgtcaaac  54540 

agagcaaaca aacataaaat agataatact cagggaaaaa aacccggtag actccagagt  54600 

cattacaata tattacaatg tccagttttc aattaaaaaa aacaggcatg taaagaatag  54660 

gaagaaaaga cagcagaaaa ggcattcata gaaagggact ctttgatcta gcaaagactt  54720 

ctaggcattg cttttatttt gatacagtaa ttacattgat tgatgtttaa atgttaagtc  54780 

tacattgcac tgtacttcca tgacaatcat tctgagaaga caaaagccat gggatcagtg  54840 

tttctcctgt tatttggcac ttagaatcag taattttgca ctaaaatata aaccccatga  54900 

atataggcac tgttatgtat tgcttttgta tccctaatga ctgaaacagt gtctgacata  54960 

gattgggtgc tcaatgaatg gttattgaat gaatgaatga ctaaaatata aactaaaatt  55020 

actggttggc tccatgaaga aagactttca gatattttcc atccatagtg aggcaatcaa  55080 

aggctgatca tgtgactcat tattaatctt attttgtatc catatttaag atttttaaat  55140 

agatgtttaa tagaagtaaa tagcaaaata aattcatcat cactagctaa atattgacat  55200 

acattataca ttttaagctg tagggtacaa ttaagtaatc tgtgaattta aaacatgtcc  55260 

aggttagaat ttcattgaaa acataatagg tgaatatata ctttaaatta aaaaaaaatg  55320 

aatatctggt ctttcagttt aatcctctac tggtttattg actgttaaac aaagttgcca  55380 

atttgtaacc tcaaaggaaa acaaagtgac cacaattatg tactgataag tagatctcta  55440 

ggaaagaaat cagagattcc ctaagcaaag catccattgg ccctatggaa attctcttta  55500 

aaacagcata aagcatgtta ttagcctttt ggtcactaga gggtggtgtt gtttcagacc  55560 

aacacaattc acactatatc cgtagtaact gaccagaaag taccaaccag aatccaactg  55620 

ccagcttcac actgttactc cacaaaacct cacagtcact tgtttacaag gtgaatagct  55680 

aaaggcagac aatataggat gaagcaaagt gctgaaagaa gagaaatacc caaattatct  55740 

gaaatgcaac acattttgtt cattggcata gaggttagtg agaggctaac aattctttac  55800 

taatacatgc cccgacgctt accatgctta tcaagtccaa ttggctacag caagcacttc  55860 

agtgggagaa gtaaaagttt caaagaagtc aaatatttgt gaataaaaat gagaatagtt  55920 

tttgatgtaa ctggaaaaag ataagccttg cttcctttgc tgtgtgaatg gtgatatggt  55980 

cttaaatttt aaatattgaa ttacactaga attttactaa ctatagatgg tataaacttg  56040 

atagccactt tcatccaaat gctttggata aagctttgtc taagaataac ctcaaatatt  56100 

attttatttt caaatgatat taggctagaa aaatactatc ccaaatacag gtttgagatt  56160 

aattcaaaat aataagacaa aagtttacgg aagattttag aatcaaacca tttcaccctt  56220 

cctagctgtt gttcccattg taaacgtgac attttagtca gtaaaacgca aaagtgcaaa  56280 

acatttttaa atgacagcaa aacacaaaat gaaattcatg ttgtgattaa tgcatcttat  56340 

taaaatggag tttaagttgc attcttgctt ttccttcttt aaaaaacata taatgttata  56400 

gtgatatttt ttcaaactct catacagaat caagacaaca gcacataaag tatgcagagg  56460 

gacatatccc attcttacct cttaacagta atttaaaagt taagaacacc catacagaac  56520 

atcagctaag ctaggaaagg caaaactgat tgggcttgtt ctgaaagttg atctgtgtca  56580 

atcaaaataa tggtctttag agtgctatat gattaagtct aatttcttaa atatgaggaa  56640 

aaatgaactt tgcaattatt tttaaaaatc ttttcatctc ttagacagtg taaaaaggca  56700 

aaaagcaaaa aacacaagac tttcccaaga ttaggggaag atgatctcac cgttaatatt  56760 

catctgctga gagcagttat gggacccatg tcaggaatac atgcttcaaa taagatggga  56820 

cttgagaatt gctgagagac ttcaggaaca ttctttaact tcatggggcc tcagttaccc  56880 

cacctttaag ggaaataata atagcaatag taccttggag gatttctgtg ataaaatgag  56940 

aaaatgcttg tgagaagtac ataaaatatt ggcttactga aagatgttac gaggcaagca  57000 

agtatgccta ttttcattca atgtttatta tttcaaaggc aaagtttcca tatagattaa  57060 

ggccttcata acatctgaat accttttcta gttcttattg tatgaagata agaaggatgg  57120 

ttggaggctt tgtaaggaat acctttctct tctgctcccc tctcactccc ataggctggg  57180 

agcagttgat ttcactacct cagatatgca aattgatgcc accttcctgt agccactttt  57240 

gccatagctg acctttttgt tgggtggtgg ggaggggagc gggcaggatt aggcgagggg  57300 

tagtagttgg gatttcttgg tcttggaatt caaccatccg atgtatttgt ttccctgtgt  57360 

ctattccctt aagtctacag gcactgtcta gtaattttat agttttcagc ggcaccccag  57420 

gggacaggac accttggcct ttttataatc actctagagt cacaaagcag aaaggaaaaa  57480 

agttaacgat cagctatgca aaggcttgtg tggattgctt aaggacaggc gattttcact  57540 

ttaccagagt tactaaagga cttcaggaga aggatcccgt ccctgtagga gcgtttgtgg  57600 

ttgaagaagc aggaggacga gcgctcaggt gcgcctcggc agtttgcctg gggtccgcaa  57660 

gtccagtgct acttattagc tgcttgccgt ccaccgacac tttagcggag aactggagga  57720 

gaccccagtg ggctcccggt ccggccagga gcagggcgtt tcagaggaga ccgtctgggg  57780 

cttcccaacc caggcgatca ggataggcaa cagccaagag aggcgctcag ttgctttgca  57840 

ccctcctccc acctcggttc tgtccacacc cacgggcgcc ccgccccctc ggccttataa  57900 

aggggactcg gcacctccgc gcgcctcgcc accagaggtt tcccagagag gaaggcgtgg  57960 

ctccctcccg ggccagtgag ccctggcgcc gccgcggccg cggtcccagc agcggagtag  58020 

ggcggcggct gcgccccgca ccatgggggg cagcccagcc ccagccgcgg taaacgccga  58080 

cctccgccgc cgcccgcgcc gcgtctgccc cctcccgctg cggctctctg gacgccatcc  58140 

cctcctcacc tcgaagccaa catgaaggag acccggggct acggagggga tgcccccttc  58200 

tgcacccgcc tcaaccactc ctacacaggc atgtgggcgc ccgagcgttc cgccgaggcg  58260 

cggggcaacc tcacgcgccc tccagggtct ggcgaggatt gcggatcggt gtccgtggcc  58320 

ttcccgatca ccatgctgct cactggtttc gtgggcaacg cactggccat gctgctcgtg  58380 

tcgcgcagct accggcgccg ggagagcaag cgcaagaagt ccttcctgct gtgcatcggc  58440 

tggctggcgc tcaccgacct ggtcgggcag cttctcacca ccccggtcgt catcgtcgtg  58500 

tacctgtcca agcagcgttg ggagcacatc gacccgtcgg ggcggctctg cacctttttc  58560 

gggctgacca tgactgtttt cgggctctcc tcgttgttca tcgccagcgc catggccgtc  58620 

gagcgggcgc tggccatcag ggcgccgcac tggtatgcga gccacatgaa gacgcgtgcc  58680 

acccgcgctg tgctgctcgg cgtgtggctg gccgtgctcg ccttcgccct gctgccggtg  58740 

ctgggcgtgg gccagtacac cgtccagtgg cccgggacgt ggtgcttcat cagcaccggg  58800 

cgagggggca acgggactag ctcttcgcat aactggggca accttttctt cgcctctgcc  58860 

tttgccttcc tggggctctt ggcgctgaca gtcacctttt cctgcaacct ggccaccatt  58920 

aaggccctgg tgtcccgctg ccgggccaag gccacggcat ctcagtccag tgcccagtgg  58980 

ggccgcatca cgaccgagac ggccattcag cttatgggga tcatgtgcgt gctgtcggtc  59040 

tgctggtctc cgctcctggt aggtagttcc agggttgggg gaagtcagga tgcgtgtgcg  59100 

agtaagcggg aacctaagac tttgctaagt ggcagcaccc gcaggggtgt gtttgcaacc  59160 

gcagagcgct gaagtgtcct ttcctcctgc ccgcgcggtc ttggttacag cttcagagct  59220 

gagctcctca cttactagct gagcgccttc caagagccag gattcgcatt aggcactgtt  59280 

tatgagcaca tagagatcac agggctgctc acattctagt cgggtaggag acaggatgtg  59340 

tcattgaaat gacatatatg cagagctaga agtttgtcct gagtgcatta aaagcagaat  59400 

tgctatgata actgtagcct gatattgtgg ggtttttttt tttttttttt tttgagacgg  59460 

agtctcgctc tgtcacccag gctggagtac agtggcgcag cctcggctca ctgcaagctc  59520 

cgcctcccgg gttcacgcca ttctcctgcc tcagcctctc cgagtagctg ggactacagg  59580 

cgcccgccac cacgcccggc taattttttt tttttatttt tagtagagac ggggtttcac  59640 

cgtggtctcg atctcctgac ctcgtgatcc acccgcctcg gcctcccaaa gtgctgggat  59700 

tacaagcgtg agccaccgcg cccggccggg tttttttttt ttaatttcaa attcctcttt  59760 

cacgttaata agattttcag tctgcaaccc catacagtca cagccctcct gcagcttctg  59820 

aaagactgcg cgacctatgg gtgccttcaa ggttcattct tgatgaggca ggagaatgaa  59880 

agatacgagt tgcctcctca gcctttcgcc atggtgcttg accctctagg aagtgcccga  59940 

acgacagtca gtgggatccg gaagctcagc agcttcttca ggccagcatt tacttaccct  60000 

tgtagcactc aagcagggtt cgctaatcct gagataggag gtagaggttt ctccatgtcc  60060 

tagctcctca caccagagca atgcagagga gcaagggatg tttgcagagg ctctttgcct  60120 

aacacctgcc cttacgtgat atttttgagg tttttttgtc tgtgttactt ttagctagaa  60180 

atgtccgtgt gtaagtgctg tttactaatt cctgaagaat ggatgcttac ttaggccctg  60240 

gggtgtctgg gttaatagat gttgcagaaa gagcgatatg gtcactgtta caaaggtata  60300 

accaactata tgtattatac agttgtggaa aacctttgaa acacgtgaac gcagtttttt  60360 

ttctttccta attatggtaa aatatattac atacaattca gtattttaac cattattatg  60420 

tgtacagttc agtggcatta ggcattaagt acgttgagtt ttttgtgcgc catgtatact  60480 

tttaaatccc ttgcatttga aaatagaaat gtaatttctt taacctggtt tggtagattg  60540 

gagcacaaac cttggctcca aatcagtgac atgaggggac aaggagtgtt atgctgagac  60600 

ctaactgccc acaagtcgct gtatggtcac agttctttat tccaggagtt ggaactcagg  60660 

ctgatgtcat cactatggct tatcaaaacc agcaccagtt ttagatatac agtatttact  60720 

tttatggctg aggaatggag tgtacaggtg gccaactagg aaggaagaaa gagttctaaa  60780 

tagtaaacac tttactaaag tgtggtaatt aatataactt taaaggcaaa cagggtatca  60840 

gtttttcaca agtgtcattt gagtcccaca tctttgagtt tgctgtatca catgatttat  60900 

atcctaggga aaaaaaatgc agttaaatca attgaacaaa atacccatac agttaatcag  60960 

acttataatt tattgtttgt gcattttgtt tttaagtcaa agcgaagcca tgtagtgtgt  61020 

ttttgattta gacactttaa ttctagtacc aaaagtatgg tggcctcaga aagaaagtag  61080 

atcaatcttg aaaactgtaa tttaggatgg ccaaactcac tctttcaaga aagactgcat  61140 

ttgaaactag tcttacttaa tttcaattta ttttcatttg gataatactt attgatttat  61200 

agcattttac tgggtacttt attaattcaa ttataaaaac attaaacaaa ataaattaaa  61260 

catgtgatca tatcaaaaag gagaattttt tttttttttg agactctgtc tcaaaaaaaa  61320 

aaactccagg ctggagtgca gtggtgagat ctcagctctc tgcagcctcc acctcccagg  61380 

tgcaagtgat tctactgcct cagcctttgg agtcactagg attacaggcg cccgccacca  61440 

cacctggcta atttttgtat ttttagtaga gatggggttt caccatgttg gccaggctgg  61500 

tctcgaactc ctgacctgag gtgatccgcc cacctcggcc acccaaagtg ctgggattac  61560 

aggcatgagc caccgtgccc ggcctaggag aaatgagaac tttttaaaga aaatggttcc  61620 

atcggctggg cgcagtggct cacgcctgta atcccagcac tttgggaggc cgaggtgagt  61680 

ggatcatttg aggtcagcag ttcgagacca gcattccaac atggccaaac cccgcctcta  61740 

ctaaaaatac aaaaattagc ggggcatggt ggcatgcgcc tgtaatctca gttactcggg  61800 

aggctgatgc aggagaatta cttaggctag ggagacagag gttgctgtga gccgagatca  61860 

cgccactgca ctccagcacg ggtgacagag caggactccc tctaaaaaaa aaacaaaaaa  61920 

caaaaaaaaa actccaaata tcttcaaaaa gatttactgt acaaagttgg aattactaca  61980 

aagaaaagaa actggcaaag ctgctttctt aatagagaat tataagaata aaaacactag  62040 

aatttagtga attgaatttt cagcatatta gtgttaaaat gagagattaa cgctgttttt  62100 

tctaactatg agtgtaatat aggtttcctg ctagcattcg ttaagttggg tgtaggatac  62160 

tattctaatt gtccaaactt cttacttgaa aggaccctga gtatatcctg gaagactatc  62220 

atgactataa taaatattca gttgttactg caggaaaact tggtagtaca gaaacaccat  62280 

aataagaaaa tgtcccaaca gctacaagtt cacactacat aaatacttaa atagaggttt  62340 

atgtatcctt aaacaaaagc tttgtttcct ttttcttttt ctcagaaatt ttgcaaaata  62400 

caatataaaa tgtgaaatta agagagtaca gtgggaaatt atgtcaccat gatagatgac  62460 

ctacagtttt tagttactgc ttatgtaagg catcacattg tcattctgtt gcaatcagcc  62520 

agttcatcca gcaatgcaat ctatttgatt tttatcatta ttttatgttt tatattttat  62580 

gaatgatgct caccatagct cagttgtttg acctgatagc taaatttcca gaaatgggaa  62640 

taaccttagg attttgttca aaggaagcta tgagtacatt ttgtactttt ataacttggc  62700 

actcccaaac aggtagaatg tggctaatac tgtaagctat ctcaaaaaca gtaaatacaa  62760 

agccagctat gaacatcatg aaaagtgagg tatgagcaac aaacagtttc tcatcatcaa  62820 

tcttggaact ggataaaagc agccttagaa acttttgcct ttaatcttga accactgaat  62880 

tccctgctca gtatccacaa atacagagat gtttcagttc aagaagatat ttcacaatgt  62940 

agttgtgatt ttttttcatt ttagttaagg agtcactgat gtattttgac aagcgaaatt  63000 

tgcctttaat atgccacatg tggtagatat gtatgatgaa ttattttcag aaataatgtt  63060 

gttttatagc atataaaagt attattcaat tgctaatctc ttctgcctca actttctgcc  63120 

atattcagga tgttgcttca gagaaagtga ttaaacatat gaatccacat tgtaggaaaa  63180 

atattctata atttttctct tttgaaaaag gtgtgaaggt caacaaaata ttctatgatt  63240 

ataaaactga ttaatgttat aatctgttca gaaaagcaga atttccacat ttatgagtga  63300 

aatatttaaa gaattataat acaagatagg atgtaattaa tgcctttggc tctcagaaaa  63360 

aagtcagtct gaatttgcca gaggagattt ccaggaagat gaattggcat aacctcattt  63420 

catgacttca tgactgagag caagtgtgtc ccaaaaccca gcccaatgag aacaaagggt  63480 

gcacactaga tcaatgggaa tgatgtttta aaaatgttca agaaaacaaa tttagatggt  63540 

tagtccctga atgacaagat gaggacttca ctcttttgag tttatcagaa agagccaaga  63600 

attaaacact tcttaagcca tcatctttga agaaattcac atggtctgaa gttgtaatat  63660 

aattgtgagt cactggccct tctcttttga acaagctgtg aaggtcaaca actaaattat  63720 

aaaagtttcc ataggtttag ttttctggga ctaacactca ggaatatgca ccacaggcat  63780 

ctgtaacaga ctatgattca tctgagggtg cagaggggtg gtaggtgagg gatactgggt  63840 

gctaagtttc agtttttggt tctgcccttg cattgcagga cagaaatgca gggaagtccc  63900 

ccctaaaacg ctgtacatct gcgtaacatt tttgcaacct gccagtgttc cacatttatc  63960 

tcattcatgc ctcacaacac taagatctac aactgtaaca tgtcaaattc ttactctccc  64020 

attttttcca attgctttac aaaaagacag gaaggaagtt tgtatttcaa ctcctgccag  64080 

ctgtgcttct tgagaatcat tagacaatct ctctagtcct ccttttccct agaaacttcc  64140 

aactttcata aagatggtaa ccaatgaagg agcctcattt tgggggggtt cctcttatat  64200 

cttgtcccct aagtatatgg caacatttta ctgtaaacat agtaaagaca gtctctgacc  64260 

tatgcttttt caacttcatg atggtgtgaa aggaatgcac attcagtaga aactgtactt  64320 

ggaatttgga atggcgatct tctattgggc tagtgatatg cagtatgata ctctttggtg  64380 

atgcatgcac agctcccagt cagccacgca aacacaaggt aagcaaccaa tactccacag  64440 

tggactgtgt tgccagatga ttttgcccac ctgtaggcta atgtaagtgt tctgagcatg  64500 

tttaagatag gcaaggctaa gctatgatgt tcagtatgtt aggtgtatta aacgtattaa  64560 

acgcatcttt gatcttacaa tatattcaac ttaacaatat tttcaactga cagtgagttt  64620 

acccagacgt aaccctgttt taagttgagg aacatctgta attgattctt atacagaaat  64680 

gacagttggg cagcatatga ctgagataca tacaacatgg gaactctctg tgaattcctg  64740 

caccctgctc tctttacaca gagcacttct ttctccattt ttcattgcca ctttacccct  64800 

cagccattca gcaatatctg ccaagcaccc acctctcttg gattggctaa gatctcaagt  64860 

tagaagccat tttctagcga agccttcctt catcctctct aggccgtgat tgggtgccct  64920 

gatctcatga taccccgcat ttccctttca cagtctgagt cacacttcat tggagacatt  64980 

ggtttattgt ctttctgttc ttttagttct gctaaggtca agtacagtgt gtgtcttgca  65040 

cattattttt tcctaggaac tatcataatt gcttgccaca taaggtctgc ccaatacgtg  65100 

tttattgact gaatactttt ttttttcttt tgagacaaag tctcgctgtt gcctaggctg  65160 

gagtgcattg gcatgatctc gggctcactg caacttctgc ctcctgggtt caagtgattc  65220 

tcgtgcctca gcctcccgag tagctggggt tacaggcatg caccaccaca tgccctgcta  65280 

atttttgtat ttttttttta ctagagacgg gatttcacca tgttgggcag tttggtctca  65340 

aactcctgtc ctcctgtgat cctctcgcct ctgcctccca aagtgctgtg gcattacagg  65400 

cacgagccac cgcgctggcc ttgactgaat acttgagcaa ccaaatcaga agacagggtc  65460 

tggccccatg taaataagca attacttttg gccttagaca attcacttga taactttatg  65520 

aacccttccc ttcctttcct ttcctttccc ttcccttccc ttccctctcc tcctctctct  65580 

tttctttctt tttttctttc tctctttctc tttctttttt ttctttcttt ctttctttcc  65640 

ttctttcttt ctttcttccc tccctccctc tctttctttc tttctctctc tctctttctt  65700 

tctgaaacaa aaatgcctac ccagctcatt tcacagtgtt ataatgaaaa ccaacaagat  65760 

taacatatgt gaaaataatg gggtagtata cagtactatg aaaatacttt attactgagt  65820 

ccttttagca agctgggaac attccttcca tatgaggaat accactgtga tgttttactg  65880 

gatagtagtg ttgactcttg tgttgagata gacctttctc ctagcaaact ggagaaagga  65940 

ggcaagtagt gtttcacagc ttgattagtt atagttcatt ggggaaaaaa tgtggtggag  66000 

aatgcaactt tcagaaacag aaagaaaaat ggtaaaccaa ctgtgcctaa tttttctttc  66060 

tttttttctt tttttttttt tttttttttg agacagagtc tcgctctgtc acccaggctg  66120 

gagtgcagtg gcgcaatctc cgctcactgc aagctctgcc tcccgggttc atgccattct  66180 

cctgcctcag cctcccgagt agctgggact acaggcgccc accaccacac ccggctaatt  66240 

ttttctattt ttagtagaga cagggtttca ctgcattagc cagtatggtc tctatctcct  66300 

gacctcatga tccatccacc tcagcctccc aaagtgctgg gattacaggg tgcctaaatt  66360 

tttataaggt attgtaattc atccctcctt ccctccccct gccaccatcc ctcctctgca  66420 

ttctctcagc cctgtaatct gttccctttt acagcttcta gttagctctc taactccaaa  66480 

acacactgat cccatttccc ctttccctta cacctgaggg aagagctagt accttgtgtc  66540 

ctgaagacct ctgtcacagg tctggaatgc tcttttctgc tcgatggccc tgagaagggg  66600 

aggacttatc tgcagtgaac agttcccctc cccacctgaa cagtcattcc tctgtgttgg  66660 

agttaaatgt gggtcttgct agcacccaca gcctctcatg tgagctcttt ccagtcaggg  66720 

tcgtcttcct gttatcctat atgtgcacaa acctattctc aatggaatct tgagttgaac  66780 

taattgtgca tctaactgtt gtctaggatc aagtcattct gcaaacttct tgagagagtc  66840 

tctccctcag ttgtcttcat cttttcacag gcaattagaa atgttgggac tgaacagaac  66900 

ctgtgctgct gactgacagc ccagaattga atttacacaa gccttaagtc agaccaaagt  66960 

gtgtgaatca tagagttgta aactgcttca tacagtttga ccaggtcctg acaacacatt  67020 

aatattattt gtggcctgca aatagcacaa tgtgttattt ttctatccag tggcctttcc  67080 

agatattctc tgggaccaca tttataggga ggacatttca gtgacttatg tgggtgctta  67140 

cttaaaatcc aaatattatt ttagtgaact aattttatga tagatatttg aaggatcatc  67200 

gatctaaaat gaaaaatggt agcagaaatg gaagaggagg cttgagtatt cacactttat  67260 

ttttagaaaa aagaaaatgc ctactaattt aggcaaaagt tgtgcaatat agatacaaga  67320 

taaattctcc accagatacc attactgttt aaaaactctt ggtaatacaa aaacaaaagg  67380 

ccatgttgga actggaagcc tgtttatttc aagcaataat tggtccccaa atattaagtg  67440 

taatttaaaa catatacttt ccactaattt tttgttatat cctgagagta aatttgattt  67500 

gtatatcttt ttgtctctct ttctgaacac ataataaatg tcattttcta tggttgagaa  67560 

tatgctgctg ttgtgattca taaaaatttg gaaaaaagaa gtgtgtgatt aatgttgaaa  67620 

atgatgaaag agtgattgta aaagataaga ttcattctga gaaattcaca agacagtaaa  67680 

gtggagcact aattgctgtt tgatgtatga aatttcactg gtaacatctt gctaccaaca  67740 

accttatttg ggtcagagct cctggcagat cacacacttt catatttccc caaatagaag  67800 

aatgcctcaa cagccagctc ctcagccaca gagtagcatc agtgattaag tgacccccga  67860 

cttgtgagga ctcctctctg cttcataaga agaacagaag aaagttatta aagaagcaag  67920 

tgagtgccac agagagaaca aggcactgga tggcaagaga cctggatctg gtcacggcct  67980 

tgccatgtga tctaagtcac tttatcttgc cggactttcc ttttctaacc ggtaagataa  68040 

aacgattaac gactctaatc ctcctttcag ttctcacttc ctgtagctct aaatagatta  68100 

aatcgtccct attggacata ctatttcaga tatatggggg aaaatacgta aaaacttatt  68160 

aggaaaaagc atagaaatgt atgcaaatgg acaaaataga tcacacattc ttttatccag  68220 

cgattctata aatatttatt gagagcttgt tatgtgcctg ccactctcat cactctggta  68280 

atacagtggt ggtcagcacg gattcattta gctataaagg ttgagcagtt acgttgctcg  68340 

agagagtgct attcacatta tattgtaaga caatgacaat ctttggagtt gagcagtatg  68400 

caatctgtgc agctctacgt ggtagcctcg atggtaagcc aaatggaatg ctatcttcct  68460 

tcacatagct ttcagtctac taaggtagac agacagtaga taatcagtcg ttccaataag  68520 

ccaatgtaac tagtcggata ggtcttactg tggttgccct tactatcaca catgagattg  68580 

gcctcatgtg ggcaggacac ggctggtcca gtgcagcatg atggccctaa tggaacacgc  68640 

ttggccccaa ctgtactggg tctgtgcttg gactccataa ttagggagca cattaattca  68700 

cacctgtgac tccagctgta atgctcagct gcaattctcc gagcacaaac actgccagag  68760 

tgagtacatg gactcaaagg gctgctgacc tcaggccaca tgctgctcta gaatcagcct  68820 

tacttctggg atcattaggc tctgggtggt actcagatta tctcctgaga aatgtgtctt  68880 

tccctttctt tttttttttt gagacaaagt ctcgttctgt cacccaggct ggagtacagt  68940 

agcacgatct cggctcactg caagctccgc ctcctgggtt catgccattc tcctgcctca  69000 

gcctccccaa tagctgggac tacaggagcc caccaccaca cccggctagt ttttgtattt  69060 

ttggtagaga cggggtttca ccgtgttagc caggatggtc tcgatctcct gaccttgtga  69120 

tccgcccacc tcggcctccc aaagggctgg gattacaggt gtgagccact gtgccgggcc  69180 

cctttctttt attttttatt tttaattaat ttattttatt ttgagatagg gtcttgctct  69240 

gtcacccagg ctatagtaca gtggtgtgat catagctcac tgcagccttg aactattggg  69300 

ctcaagtgat cctccagcct cagcctctgc atagttgtac tattagttgt gcaccaccat  69360 

acccagtttt tccctttctc taagttttct tttaaggctt gtatgtcttt tccctgtagt  69420 

gaatgtggcc aaatccactc tgctccaagt tttttggctt caaatcttga gagaagaggt  69480 

tcagtttctt gatctcctct ttgaccagaa gtccctgggc cccttaagca ccatctacct  69540 

cttcccaagt gaccacagag tgttgtgtgg gttttccttt ggtataccac acaatttccc  69600 

ctgtgtaaag ctaatgattc caaatttacc agaataagta attcttctga aacttctgct  69660 

ccaatgtaat ttgttctgcc cacttgacca gagaagtgca gatggatgct ggcatacctt  69720 

tttatacatc aaaaacgagc actttatgaa ggcaagagaa aggtaatttg agagagtgtc  69780 

aaggaagatc tcctactgat gcattgggat tagggagggc atctctggga aaaaggtcat  69840 

ttatgacgag tcttacaaga taagacctca aggaagaaag agcagtatgt gaaggtgtca  69900 

gtgcaggaat acactggaag cattggagga actgaaagaa ggccagatgg atggattaga  69960 

gtgagtaaaa aagagattgc ctgcaaggcc agctagggag ggaggcaggg ccagataatt  70020 

cacaaccttg tcatttttgt ttgggagttt agatttctac cacaagtaca atgaaaaaca  70080 

actgaaagct gtaggggaat gatttgatct gcttcatgtt ttaagaccac ttaaggttgc  70140 

ctaatggatt agatgggtag agcatcagag ccctcgagta ctgaggacag atggagatgt  70200 

agagacatta atataaagaa aagccttctt ccttaaatgt tgctttaaaa gaggagtggg  70260 

aagtagcttg gcctagaatc ggtgagagag gggaagcagc agtggatctg tgcagatgca  70320 

ccacggaaaa tattgaacca gatgtgctgg gaatggtaag cagatctgtt tttgtagaag  70380 

tacatttgag aatgtcaaaa actatagata tagtcaaata gagactgaag ggaaagggag  70440 

aaacacataa gtagattgct taagattagg aatgagaatt tgtatttcat tttgggcaat  70500 

ttgtattgat tttctatact gttctatatt tgtaaaataa gagagtgtgc attataaaac  70560 

ctgaattcac aaacctcgtt taggaaaaca actcatctaa tatttgatat ctttctagaa  70620 

tattcttagt gaaattgttc cagctttgtt tacactttgt tgaacaccct taataatagg  70680 

aaatttttta cctttcaaga actctaggaa ttttcttaga gccaagattg tgccaggctc  70740 

tttctcacac atactttttt taaaatttct tgcaataacc ctatgagata ggcatttttg  70800 

tcgccaaagt tattatgatg agaaaactaa agctgagagg agttgagtga tttgttcaag  70860 

gtagcaaagc tattaagtag acaggctggg attgaaaggc caataaattt tcaataaaga  70920 

aacaaagctg agaaccattt agaattcatt tgtccatgtt tcctccatgc catgatgcct  70980 

tagaataccc caattcatct tgagctgttc tttgtattag aaaaattcat ttcccttata  71040 

ttgactgagt cagaatctgt cctccctttt gcttccaccc ttcggtgcta atactagctc  71100 

ttggattagt tagagcaata ctacatttat ttttatttta ctattatgtt ttatcacaaa  71160 

gaggttacat tttttactga caactcagtc actgcataca tactttattg cacaagttat  71220 

aagtggatca acaattatat tagcaatgta aactcatgtg catttacata aaatgactgc  71280 

cctagattct ggtgcatttt gtgccaggta ctttggtaaa tatggcaaac ataaagggac  71340 

ttagctattt caatttatgt gaacaaaagg tagcatatat atcatcttat aaaatacctg  71400 

ttatgtcaaa tccaggaaaa tcaataaatg acaaaaggaa cacattaaaa gaaaatttag  71460 

cgataaaaat gttagattaa aatattaggt ttaaaaactt taacagtttt tccctgctag  71520 

tataaatcat tgttttgtag ttattaatat aactcacata aatgagtttt aaaataagat  71580 

tcttctcact caaaataaaa taagataaaa ctaatattac ctccaccaaa ttacaaagaa  71640 

atcctatcaa aatgctggcc agataaagaa tccagataca gacacatcat aacaatacta  71700 

aatttactta aagacatctt ttatttttaa aggttttttt aatttttaaa gataaaaata  71760 

ctataccaat aactatacag agtagtatta ctaatgcagc attatattat taggtaatga  71820 

ggagttctac taagttttta agcagaaaaa taacaaaaaa ttaccttgac cacggcagaa  71880 

ggaggagcca tgatttataa tttatttagc agacacttat tgaatactga ttgtgtgtaa  71940 

ggtagtgcta caatgacgtg acccttgtcc tcaaggaatg tgttgtcttt aagacgattt  72000 

cctggagaaa cttgaaattg actcaaaaaa aaaagcagca gcattttcca tctttaattt  72060 

tcaaaaaaag aaacaaagct gagaaccatt cagaattcat ttatccatgc atgcaatcag  72120 

tatttgttta ttgagtccat acaatgtgtc aggcacagtt ctaggtgctg gaaatatggc  72180 

agtgaattag gctagtttca tgctctcagg gaattagcat tctagtggaa ggagagaggc  72240 

aataaataaa ctagaagtct agtgattgtg ataaatacca ttaagaaaat gaagcagtgt  72300 

gccagaataa agcctgaagc atccttctgg cagctatgtg gagctggatt gcagaaaggt  72360 

atgtgtggga acagggacac caggtagaag gctgttgaag tcatccaggt aagaggcggt  72420 

gacaactggg attggagtga agtacccata ttgacatagt gttttggaga cagtttgcca  72480 

gacattttga aatttctcta atccctgtcc tatgactctg acaagaaata ggacctctct  72540 

cttcctctcc aggcctttgg ttttgaggtg gccagctatc tacatatggc tttccatttg  72600 

gctccccaag aaggaagtga ctgctctaag cttacacaac taggaagaga gaattaggag  72660 

gtaaatttga tctaatagat gttatttcct tttttctgag acatgaatca gaacagtcac  72720 

acagagacac agaagttacc aaaatttgct tataaaataa tagaatgtca taagattcgt  72780 

gatccccaga agatctggag catgctgatt tccaggctag gtctcagaag aaactttttg  72840 

ttgtcattgt tctttctaaa cgggttctgg ttactgttgg cctctttttc tcctaaaagg  72900 

agagcagttc tcaaattaat actccctact tttaaaatca ggattgtttg gctgcaaatg  72960 

atcgaaaact aatgcaaact agcttaagca aataaataaa tataaaaagg tagggggagt  73020 

tgcttgattc acataaattg caggagtgtg aagagtggag gtggccttat agaagatgga  73080 

agccagcact gtctctttct gagactctaa cttcagcttc ttgctatgta tcagaatccc  73140 

cacttcaggc tctgctccta aggaaccagc ctaagccata gctttgcagc tctttggcta  73200 

ggtcttgtgt tcttttttca aagcttcaag ttaataagtt tatatttgtg gtctacatgt  73260 

gaggttttaa ttttgctttt ataataatac aatattttac tgaatacatc atcttgaagc  73320 

actgtttaga catcatagat tttttctatt gttttgtttt ataaacacaa gaaacagtca  73380 

tagatgacaa agttgcattt tcaaagacta gtatgagttt tctaggctat gaggaaagat  73440 

tcaggctcag agaattttcc agattcaggc tcagagaatt ttccagaagt aagagtataa  73500 

tgagaggtgg ccttataaga cgaaaatctc acgaatactc cattaacacc atagtgagat  73560 

gactagagaa gaaaaaagaa gttctttctt gatttttcca taaaggatga gttgtagtct  73620 

gggttttatg ttattctggc aaccagcttt ttctttataa atcagtagct gtgctaacgg  73680 

ccaacatgct gggtggcaga cttttgaatt tatttaatgg tagtaatttt ctccaagaat  73740 

agactaggga tttgcctgga tccaaaagca aatttcttaa tattagcttt tgctctataa  73800 

aagacattag ggaacatttt aaaattcttt tctctagcat ctatttctaa ttaaattttg  73860 

ctacagatca atatcaggaa gcatggaata tcttctgact tcagaattct accctcctcc  73920 

ttagacatgg ttctgggttg caaacaacca actgtgactc caagtgcaaa gagcatatgt  73980 

agaaggattt caggagctca cagagtccag agaaatctgg caggtcaggt ttggaaaaca  74040 

ggcaagaccc aggatgttct tgatgatgaa cttcaggctg cacagccaaa gtcctgctgg  74100 

aaaaatgttt gctgcatgcc tctgtgatga atccaatgtc taaaaacccc cttcttcttt  74160 

gtgttatgct tgtaaaattc aaacttctgt tgccagcctg actgctgtag cttgggttat  74220 

ttacccctat gctataacaa aggatgaagg ctcaggcacc tccagcactt ggtttatgac  74280 

atatgtgctg ggatttctct cccacccaga atacagagaa acggttatcc agaattggga  74340 

tattaataat aaaaggtggg ggttcatttt taccatctat ccaatttatt cgtagaaaca  74400 

ttataatagt aacatacttt tgaagccttg tgcacatgtg cgtgtgtgca cgtttgtgtg  74460 

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttttcctg ccacctatct gttgggaaat  74520 

tggggtagca gtgagactgg tggagcgcaa actgaagaga gccacaaaaa ataaaaggac  74580 

ttctatttac tgaatgcctg ttatgtgcag gtacatactt gacaattacc ctttccatat  74640 

attacctaat ttaatcttca caacaatttt tgagtttgtt acctttcatt cccatgtttc  74700 

agttgcaaat aataagacag aaaagatttt ataactttct ctaatcatat tcctagtaat  74760 

tagtagatct taggcttttg tacactataa tgctatgtgt cacgtttttc tctcttatta  74820 

gtttataaaa atattttcaa atcacttcgt tgaaaatatt gtacaaaaaa gaacaaattg  74880 

attgagaata gtaaaaaaaa aatcactgaa attgtctggg tcagataatt atggtgatgg  74940 

agatttcctg tagaatagct attgattcat caactgattg acctttgtag gagcttgagt  75000 

atctagggag catattctga aaaatcccgt agaaggtgac aggagttttc acttgtctga  75060 

cagtaacttg ttaaatgatt ccattcacca cgataccggc aatttaggaa gtgttttttg  75120 

taaaggtgtg gcatcaattt tatttacttc tgtgtgtctt ttaggcttag aacattcaca  75180 

tccagtgata aagttttact aggcaaacat ttttcagcta gtacaagtca catatattat  75240 

tcttttcact aaactattta taaaacaaat aaaactgtat attgaattct ttttgcttgg  75300 

tgggaaagtg tttgactaca gtcaaaatta gaaactttgt tttgacagtt ctaaagcctc  75360 

cagtatgata cagtgcaatt gggattcttg caaacctgct ttcatctttt ttcttataat  75420 

tagggaaaag agaaagagcc ttagagaacc tcagtgtgac cacggtgact ctctaacatg  75480 

gaattcaggc atgttactat agtagcctct cacccagatt aaaaggcttc agattcctta  75540 

gtttaatcct caagatcttg gatttggcca catttaccac tgtaccattt ttttccatcc  75600 

ctaccccagc atccttacct tcagtgataa aaatcagttt gcagctctta taatgattca  75660 

cacaatttca cactcagaaa tgtggacttt gtctcaaata cctacaaagc atctgctgtt  75720 

ttggcagaca ggggtttctc tgaacctaga aacttattta tttatttact tattttgtta  75780 

ttattattat tattattatt attattatta tttgagatgg agtctcactc tgtcacccag  75840 

gctggagtgc agtagcgtga tctcggctca gtgcaacctc cacctcccag gttcaagtga  75900 

ttctcctgcc tcagcctccg gagcaactgg gattacaggt gtgcaccaac acacccagct  75960 

aatttttgta tgtttagtac agatggggtt tcaccatgtt ggccaggcta gtctcgaatt  76020 

cctgacctca agtgatcctc ctgcctaggc ctgccaaagt actgggatta caggtgtgag  76080 

ccatcacgcc cggccataga aactgattta agtgcccctc ctctttactc catagtgcct  76140 

gtgcatacct ttatacttaa ttatgcacag ttataattat ggcaatgagg atgattggcc  76200 

acaatagaca aatgcttatt ttataattta tgcacattgc atttcacaga tataatttca  76260 

ttttgttcta ttgatgacaa cttgagggga tactgtcatc ttcgttttca gaagaggaaa  76320 

ctggttttga gatgtaaagt aactttcttg gggtcaaatc cagatttgtc tgattttatt  76380 

gcctatgtaa ttaaccacta agctttatgg tctccctcta tttgtctgat tcagtttaaa  76440 

ttataaactg cttaaaagca gagatcttgc cttgtttttc aataaatctt cctggcccaa  76500 

agaaatcacg caataaatga ttgtgaaatg aatgaagaag ggaagtgtaa ttaagtgaaa  76560 

aggacactag aataggaata agaagatcaa ggtataaatc ctagctttaa gagttttgca  76620 

tacattagat ggttttttaa tcttcacata aatcttgaaa tgtaggtgac atcagttcct  76680 

gttttttgtt ttattttatt ttactttttc acttgttgag taagcaactt gctttaaggc  76740 

cacagatgat aaatagtgtt gagtgaatca aactcaaatc tttttcattc taaagccact  76800 

aatccaactt gaatctaatg aatcatgggt attattaata cagtaaaagt tgttagtatt  76860 

taagataata gtgcatattt ttctttattc tttactttta ttgtctccac tttgttgtta  76920 

gtaataaaaa ttctagagaa gatttaaaca tacctttagg gtagacaact gtaagagaga  76980 

caacattgtt tttataatgg aagagagaag ttaattggaa gcaatgggaa ggagcacaag  77040 

aaaacagttg ctctaatgcc tggtgtttaa agacggaaaa aatgaaaggg atgtttggaa  77100 

aggtgccctg gggataacaa ttaaacatga ggaatttcgg cgacaatagg gaaacatagt  77160 

aaaaaataaa aaacaaagga aaaaacataa tgcttcaaaa gttgctccag agtgtcacta  77220 

tatttatgtt gccctcagtc attattagag atgatgtaat gtagtggttt gggaataaaa  77280 

aacataactg aaatccaaaa ttagggcagc cttcagagtt ggttaatccg aaagctcagc  77340 

atcgtcatct aggaccaaag tttgccgcat ctctctttcg cagtacagtc ttggcttcat  77400 

cctacggctt gttccccgca agtggtagct gtagtacgtg cttcctggtt aacttctagc  77460 

aggagagaga agctgtgttt ttctatgact ttctcttaaa aacgaggaaa ctgttggatc  77520 

tcattagcta gtatggggtc acatgatcat ccctaacccc ggcacattcc tgtagctagg  77580 

gatggggtca gccctgaagc acataggatc cagtgaaaat aactatgtcc atgagcaggg  77640 

gagatggatg aatggaccct gggtaggtga ccaatagtgg acactgcagt gatgatacct  77700 

acacagttta attgacagaa taaaggtgga aaaccctcaa aaagaataaa gcactaaact  77760 

ttcatctata cagcatagta gcatagtagc cactagccac atatggttat ttgcctcttg  77820 

aaatgtgatt aatccaaatt gagatacttt aaatgtaaac tacacagcag agttttaaga  77880 

ttaaatacaa aaaggtaaaa agtaaaatat tgcattaata atttttatgt tcactacatg  77940 

ctgatgtaac atttcagata tattgggtga attaaaattc aaaatgtttc tttttacttt  78000 

tttaaaaaaa atctggctac tagaaaatgc aaaagcatac atgtgctgca gatttgtggc  78060 

ttgaattaca tttctcttgg atagtactgc attagactga tgattttcca attgttttaa  78120 

ccggggggac tatgtcaata catctcttta gagaaataga tgaaaacaga cctgttctgg  78180 

ttaaatgggt tggggaaccg gatagttcca agtctcaata gatctatttg ccaattcctg  78240 

caaaaccatt cctgaaaata tctacttcgc cttggtgagg ttgcataaaa tcttttgttt  78300 

ttaatttcag tgctttgaga ggccaaagca ggagaatcac ttgaggctag gagttcaaga  78360 

ctagcctgag caatgtaggg agatgcctgt ctctacaaaa atttaaaaag aaaaaaatta  78420 

acccggcatg gtggcacatg cctgtagtac tagctactag ggaggaaccc ttgaacccag  78480 

gaatttgagg ctacagtgag taaattatga tggcattact gcactccagc ctcggtgaca  78540 

gagaaacccc gtctcttaaa aaaaataaca aaagaaactt acatcaaata taggatttta  78600 

gatgaattca ccaaaagcat tttccctatg atagttgtag gaactgtttt attattactt  78660 

gtttaaggtc ctccctagaa ggtaagtagt acagtaagaa ttgctctcac tgggttcaca  78720 

cgttaaggag agagggagtc aatggtgttg ggatctgttt atctttttac aggagcctgg  78780 

gagcctgtga tcctcatagg agttaggcat ttgagtcatg gtaggaacag gtttcttcct  78840 

catgtttgct tccttcttgt tcttattatt tactttgctg ttggaccaac ccagaataca  78900 

gagaaaaagt tatccaaaat tgggatatta ataataaaag atgggggtcc atttttaccg  78960 

tctatctaat ttattcttag aaacattata atagtaacat atttttgaag ccatgtccaa  79020 

cagccatgtc catgaccaaa gtcccacagc aaagtaaata ataatatagt attaatctaa  79080 

ataatataat attagtaata atatagtatt aatccaaata aatcaataga agagacaaaa  79140 

gcagcctaag ggggtaaaca cggaagatga acacattata attttccatt ttcctgcatt  79200 

gcatacaagt tgtgtcttat tcaaacttcc ttcaaacctg gtataaaatt gtaagtacta  79260 

accattattt aagtgagttt ttaaagtccg atttcctgaa aaacaaaaga aacatttttt  79320 

tcagaagttt cggaaactaa agtttacaat gagtaatata aatatcgcat ggcacttgct  79380 

ggttttcagc tgccacctat gtgttgcttc cgtttgtaat acataacatt caaataataa  79440 

caaaacagca agtagtactt acatagcact tatataggtc agggactgtg agtattactc  79500 

agttcctatt tacagtcaac aggacaagag ttagctgtaa agaaagctgg taaatttagc  79560 

caggggtgtg ttttgtgttg ggaaaaggaa aatgaatgaa tataatgtta ggaagttcct  79620 

gatgccaata ctgagtacaa gcctaacctg gggagggaat tttgcaagtg ctaaattaaa  79680 

ctgttactga tgtgttatct cagattctgg ggggtatttt aaatatttat tacagtataa  79740 

gcaagggggg agtaatcaca caatgccaga ttcacaactt gaggagctga aagtatcaca  79800 

caatagcatt gctttcgctt taacattaag aacagtctgt gatttcctaa tcatgacagg  79860 

aagtttggcc ttcaatgcct caacctttcc aaagagagcc atgttaactg ggtttaaccc  79920 

acaattttac tgcttggctc ttgtgaaggg aaaaagttgc aaccaaatat ttctggtgac  79980 

tttctctcct cttggggcta cccagtagca gcattgaaga cattcctgca actcactcac  80040 

ctcacaggca agcatagtct cttatagtaa gtattatata agcattagtt gctgttttgt  80100 

tattattcgt cttcagttgt taagcataag atatggtgtt atatttttgg gcaaaacttc  80160 

tataagcaag gagtgctaga atcatatata acacttacag taataaaagg acttttgaca  80220 

ctaagtatta gaaatttgat gatatcctca ttaaagactg tgttgatatg cataatatct  80280 

tctttttttc cttgggctat attttaaata aatgttatta gatatacagt taatagaata  80340 

tcctcttata gattcaatat attttatttt aaatacttgg ttctcctttc attctataac  80400 

cccaacttac cagcctcagg gttactactg gctgtcatct gaacaccaga acgttccact  80460 

taaaatcatg aatgataaga agatgtgctt atagtccatt agcacctagt ttgaagctgt  80520 

tatcctggct aattataata agaaggaagg aaggaaggaa aaaaaggaag gaaagaagga  80580 

aggaaggaag gaaggaagga aggaagggcc tggaatcttg aaaaggattg aatgatgttc  80640 

cccttcctgt ggccatgtgt tctcattgtg gggtggggga ggggggaggg atagcattag  80700 

gagatatgcc taatgttaaa tgacgagtta atgggtgcag cacaccaaca tggcacatgt  80760 

atacacgtaa caaacctgca cgttgtgcat atgcacccta aaacttaaag tataataaaa  80820 

ataaataaat aaataaataa ataaataaat aaataaataa ataaaagaat caagtatttt  80880 

tttcagccgg gcacggtggc tcatgactgg aatcccagca cactgggagg ttgaggcagg  80940 

tggatcacct gagatcagta gttcaagacc agcctggtca acacggtgaa accccatctc  81000 

tactaaaaat acaaaaatta gctatgcacg gtggcgggca cctgtaatcc cagctactcg  81060 

agaggctgag gcaaaaaaaa aaaaaaaaaa aaagaaagaa aaggatagaa tgtcggtaga  81120 

tttgtccatt acatcaaaac tctagaatct gtacccccaa atgggcagga tgcactatac  81180 

ccttgctctc attcacttat ttgttaattc aaaaacttta ttaatctact gggcttggcc  81240 

cttgctgtga tatacctaga atataggata gaattgatcc ctactcttgt aacaattttc  81300 

gattattgag agagaccaac aattaaaaac aagcagcaag ataaaatgta gagaagtaga  81360 

gaattatggg aatccatatg aagattgtat taaggcttgc ttttgtcaag agaaatatca  81420 

aataaattga tgtttcaaga ccacgcacga aataagtcag aatttttcaa gtaaagaaaa  81480 

agaggatgag agttttaaga cttaaagatc cacatttgta atgcctcaaa agcaagaaag  81540 

aactgtcact tttaaagacc tgcaagaagt tcaagataat tggaatactg atgcatgagg  81600 

gtaaaaaatg gtgagaactt aggctagaga acacaacagg tactcaccaa gtaaagagga  81660 

gctttgaatt taagtgtttg gactttatac tcagggcaat gtgtataaat gaaggacttt  81720 

gcaaagtgga ataacaagat taaaatttca ttttacaagc atctttttta agcagcagca  81780 

tgggccaggc cagatggagg ccaacaaatc atgtcattga tgattgtgat agttcagaca  81840 

agagacgatg gagacctcag tttatggtca attgggggtg taaatgagag aagtgataga  81900 

ttaaaaaaaa aaccataaga ggttagttgg agactccgtg attgattgga tgtgaggaat  81960 

atggtgaatg tggtggaatg tggagagaga cagagagacg tagagaaaga cacacagaga  82020 

aatgaatcaa gggtaactcc caggtttctg ttttagagat ggggatttac tgtgataggg  82080 

aagattaatg tagaaacacc tttgaggaaa aagataagaa ttttcatttt gaaaatgttg  82140 

aatttgatgt aagacattca aacaaagccg tgcaatagca gctaaactaa tccatttgga  82200 

gctcagagaa aaggtatggc ctatagcaca taaatggggt ttgaagccat tgagatgaaa  82260 

gaccacacat agtcagttta ttcacagtaa gaagaggagg ctctctaaga tacaattcag  82320 

aaatgctaac atattttgag acagcgagaa acaggagcat ataaagggga ctgcagagga  82380 

atacccagaa aggtagcagg aaaattagta ataaaatcag aacaaatggt gactcgaata  82440 

ttagggaaga gaatgtttca agagacagct acattcaatt aggtctgatg ttacagacaa  82500 

gtaagactgt ggcgttgatt ctgcaacctt gttggtggcc ttgggaacag ccttgtctga  82560 

ggatttgtga acacagaggt caggctgcag caggttttgg aataagttta aaggtaagga  82620 

gggtagacac ctcttttggg aaatttggct gtaacttctg gagcagtcta tatgtaggta  82680 

ggtgagaatt ccacacaggt tttattttct caaggtggca aaaatttgga catgttaaaa  82740 

tgtgactggg aaactgccaa aagtgggaga agttaactat aaaagaggac aggaacaatt  82800 

gagagtatat ggtctctgaa attcaggatg gataagatcc aggggctaga cagagggtgt  82860 

gccttagata gacaggacac ctcttccagt caaataagag gaaggaaaga atggatggct  82920 

gcagatgctg aagttggtgg caagaaggtg ggaagccccc taaacagatt ctgttcattt  82980 

gtgtgtgtat gtgtgtgtgt gtgcctgtgt atatgtgtgt ttgtgtgtgt gtgtaagaga  83040 

gagagagagc actgactaga gaatgaatta ggattggtga gcatacattt aaggacacct  83100 

caatctgctc atattcaccc agtgtccatc ctgaatataa gatgcatcta ttttggattc  83160 

tcctgtgaga tgaagtctta atagatttaa aaggcagtgt cattttgaca tactgcaaag  83220 

tttaataaga atgtatcata tcagattaga accatattca tcaccctgca ttgtgtaccc  83280 

actatgtcac aggaagggat tcttttgtat gtcatgtctg tattgtccat caagtccatc  83340 

actgaggcca cttaatttat cactaaattt agtaagccat aattaatttg ttgatcaagc  83400 

taaatgtttt gaacatacag agtgtcagac tgcttacctc ttgttaaatt atgcacacat  83460 

tgacctctta agaattcatc ctaaaatgac cacattatag ttctaggatt gcaacactaa  83520 

cactttacca atacatggat agatgattgt ttatagctaa gtcaccagct actctaaatg  83580 

taatgctttt taaagtgtaa aaaatagcat gtgtattgta aagaatttgg ggaaaacata  83640 

cagagaagaa aatagatatt gccataattc tcacccagag aaaactactt ctagcatatt  83700 

ttactataaa taagcacagt tattttttaa aatttggatt atactgtgca acatttattt  83760 

tcacttttca cattctgaac atttcttcat gttactaaat attcttcatg ttactaatat  83820 

tcaacagcat gattttaaat gtcagcatta gaatagatat aaattatgca tatgaaggat  83880 

ggtccatagt ttaagcagtg ctctattgtc agtcatctag gtttttctaa ctttctattt  83940 

ttatattgag gtgactatct ctgcacacac aattaattca catctctgat ttttttcctt  84000 

taagtgttta gttgttttta attgtcacga acactccgat tttctgaatg gatgagagta  84060 

aaattgaaca tttggggttt aaatgaaact atattttggg aggaaaaaac tctgaaatct  84120 

aagcattttt aaggattaat gtactttaag ccttgacaat gacatattat ctagactttc  84180 

ttttgacatc tgaaatatag gtgtttgaaa tatagtaaag ataactcttc taacttgtgt  84240 

gtcacccagc taatccatca tccataatcc aagaaatgaa tcctttgata gaatagattt  84300 

tgccttcccc ctttcagcca gaatttgaat acttacttag atattgacat tgtgtgactg  84360 

ttctaataga aagataaaca tttatctaga catacgtctt gagctattct gagccaagtc  84420 

atacagaatt tacaatttat actacttgaa agggaaattt ttatgtagca aataatgtgg  84480 

tagcgggctg ctggcttctt tataattttg attttccata tccagtaact gaataatgat  84540 

tctgcattac taaacatttt taaagtgcaa atttgaggtg agttttctaa aactacttta  84600 

ttagcaagaa attcaagcaa tatagacaca attcatttat ttctttgtcg tattccccta  84660 

agcatttttt tgttctgttt gtgaatgtca agacattttt ttttggaagc atctgcaata  84720 

gtgtgagtgc ctgaggcatg ggaagaggta tgctatataa attgaaggta ttaattattc  84780 

ttatcacatt ttaatttttg caactgctct gctagttgga gacgatacac agtaagtgtg  84840 

tgtgaatcat gttttagaga aggaagaagt taagaaccaa aattaggtaa ctagtctcca  84900 

aactagaagc agaattgagt cagacttatg gaagttcttt aactcttggt cagtatgttt  84960 

gccagaatct gctatttctt ttaataaaaa tacccccacc ccactacaca cacacacaca  85020 

cacacacaca cacacacaca ctctgctaac atacaccaaa gcttcatgaa tctagtccct  85080 

tgttctcata cactgtcttc taactttgta atttttctct ttcctccatt tgccccttgg  85140 

agtttttttt tgaagaggaa ttttgacttt tgtttcacac ctatttcctg taggttttaa  85200 

ttatttgcca aatgaaatcc tttcattttc cagctttgcc ccaaaaatca tcaaaaaaaa  85260 

actgtagagg tgtatgcaga ggccatccag tccagcccca ctgcttacta ataaatttaa  85320 

taaagttcag agataaatga cttttctaaa gttgtaaatg atggcaaaac tagcaatata  85380 

atttacttga ttcttaatcc attgttgttt taaaaaatct tataaaatta cgtagtagta  85440 

atgacgaaat ggcacaaatt ctactaattt ttttaatgtt tatgagctgt ttatttgtaa  85500 

tgttttcagt ttaaataagg cagggaaagc ttttgaaaca gtagtctagg atccagagat  85560 

gatttgacaa ctggagaact gttgtaacca gattggagag actacaattg tttcttaatc  85620 

cacagtgaag cttcttccca tgcaaatcct tcaaattaca taattaacta gtttaaaggg  85680 

cccagactgg ttttagtgta ttatgatgaa atacacttat caaattatag gggggaattt  85740 

ccagtagagc aggttattct cccataacct aacaacagag aattacggaa aacaaaacat  85800 

cgcagataaa aattggcttg tgaggaaact tctcttaaac acttgcatta ggaataaact  85860 

ggaaatgcag aaacacccca gaattgagcc taagggcagc taaccaattt atttcctccc  85920 

ccataaatta atttttctgg gtttcctcat ttatcatctt taatagatat gtgtggccta  85980 

caacccaagg catttttaaa ttaagaagtg aagtactaaa gatttttaag tgtgtgatta  86040 

taaatcctgc tgcaatagaa taaaatccaa ggatagaata ttaaagacag cctccctgat  86100 

taatgctttg aacacttaaa agaacgttat cactggggaa agggtaaatc atttttttcc  86160 

tttaggatgg aacaaggtaa ttgtacttga cagtagacag ggatggcgaa tttagaggtc  86220 

actgatgtag ttgtgttccc agttatctca agtgcataaa gaagctctct attactgctg  86280 

ataaccaagg gagagctctg ctagagggcc tgggagagtc acgtggaacc cagggaaggg  86340 

gctgacagaa cagctgcagc tccgttcagc tagaattggt ctcacgactc ccttgaccag  86400 

atcatttgtt atatgaggct gtttgaaagg agaaatagtg cagggtatat gtgtgtttgc  86460 

taaaaccagt aaacagcctc tctgttagct gagcatcctg ctttttcttt ggtccctctc  86520 

ccttgtatga cacagaattg gactaatagg aataattaat tctaccatat tcatgcctaa  86580 

ggttttctct caaagtctaa acagtctgaa agatatttgc aaacacatac acagaaatta  86640 

taattatggc ttaaatataa agactcaaca gatggatgct aatttgaatt tatgttcaaa  86700 

attggatgaa gaatttggag ccccagtttc atctctgctg ccatttggaa atggcagtag  86760 

catgctcact gcttctaatt ccaattatct ctatattgca catctcatga tttctgggga  86820 

aagctaatgt ctctcctcat gtgccagcta ctggctgatt ttataatttc agaatcattg  86880 

cattctcaat aggaaattac agtgtactaa acaatgtaag gcatatgaaa cctatatttg  86940 

cctcataaca ataattttaa attattagcc tcacaaaaat taattttcaa ataatcaagg  87000 

aggactgtgt aaaatgactg acgtatcatt ttaataagta attttgtgaa ttttcctgat  87060 

cacaaaaagt tagagaaatc caattcttta ttttatagag aaaataaaaa cataatttaa  87120 

gtgagttttt agataattct agacgaggcc cagaacactt tctggaggat agtaagtggt  87180 

caaatatatt taactattgg gtggggtaaa ggactgaaaa agataagcaa aacttttcta  87240 

atagtttata aaaagagggg aaagggatta ataagctttt tttcataaag ccaactgagt  87300 

tgaaaatatt aattttataa cttttagtca aacacattga ctgatgccac tagaataaca  87360 

ggcattcggt tttgcatgtt gtaaatttag aaattgagat aattgggaca ggagttagaa  87420 

tgaagtttac ttttacttta ttcatttatt tttaagtttc ctaggaaagt aaaaaaattt  87480 

aaagaagctt cctaggctat tttatctatg agaatgaaaa aatcgttttc aagctcattc  87540 

cttctattcc tcttaacatt ggttgagagc tcagtgtgtg ggcatatttg ttttctactg  87600 

ctgctgtagc aaattattgt aatcttggtg gctgtattag tccacctgag acttgctgta  87660 

aagaactacc tggggccagg tggtggtgac tcacgcctgt aatcccagca ctttggaagg  87720 

tcgagacggg tggattccct gagcccagga gtttgagacc agcctggcca atatggtgaa  87780 

accccatctc tactaaaaat acataaatta gccaggcctg gtggcacgtg cctgtgatcc  87840 

cagctacttg ggagtctgag gcacaagaat ggcttgaaca caggaagtga aggttgcagt  87900 

gagccaagat tgcaccactg cattccagcc tggggaacag agcaagactg tctcaaaagc  87960 

acaggttctg ctggctgtac aggaagcatg gctggggagg cctcaagaaa cttgtgatca  88020 

tggtggaagg tgaaggggaa gcagacacat cttcacatgg tggagcagga aagagagcag  88080 

agaggaaagt gttacacact tttaaacaag catatctcat gagaagtcac tcactattat  88140 

aagaacagca agggggaagt ctgcccccat gatccagtca cctcccacca agccccttct  88200 

ccaacactga ggattagaat ttgacatgag atttgggcgg ggacacagag ctagaccata  88260 

tcagtggctt aagagcaaca cacatttctc tgttctgtag gttagaagtc tgatggatct  88320 

cactgggcta aagtaaaggt gctacagggc tgcattactt tttaagtctc tgagagaaaa  88380 

gtgtttcttt gcctttttca gtttttagag gaggtcatcc tcattcctta cctcctggat  88440 

cccttcctcc accttcaaag ccagagatac tgtgtatctc tgaccattct tctatagtca  88500 

tctctccctc tggccacagc tgggaaaagt tctctgattt tttaggacac ttgtttttac  88560 

attgggtcca cgcaggtaat ctaggattat ctcctcacgt ctgggtcctt taccttaatc  88620 

acatctgcag agtccttttt gtcttgtgtg gtaacgtatt cacagattcc agggaccgag  88680 

aaatggatat ctttgtgtgt ggcaggaggg gcattattct gccttctatg atggggggta  88740 

gcattcagct cataggatga taagccagcc agcatcagaa tatattgatg taaatatatt  88800 

tattttaagt aaattcggtg tataattgtc catatttacc aaagaaggga ataataacca  88860 

tctgctttct ttaaataaaa gactttcatt aacatcattt gaaatgtttt tatatacata  88920 

caattttttt ttttttgagc ccaagtctca ctctgtcatc caggctggag tgcagtggtg  88980 

ctatcttggc tcactgcaac atctgcctcc taggttcaag tgattctcct gcttcagcct  89040 

cccaagtagc taggattaca ggcacacacc atcatgcccg gctaattttt gtgtttttaa  89100 

tagagacagg gtttcaccat gttgcccagg ctggtctcga actgctgggt tcaggggatc  89160 

catctgcctc gacctcccaa agtgctggga ttacaggcat gagccaccac acctggcctg  89220 

tgtacataca attttaaaat taaattatat tgtttaaaag taaattattg ttaaatagca  89280 

gtaattccat tgccttccac aagtctgcct attttaaata atataacaac aaaactttat  89340 

atataaagta tcttatattc tgttttttca cttaatactt atatatacta tttgtgaatt  89400 

attgttttat taagctttac acctgatgtt agagatgtat gtgtctgcaa tttcttgctg  89460 

gcatatataa tgctcctctg aacatttatt tattgtatag ctactatttg cttttattgg  89520 

ataaatcatt tggaaaaatt cctgtgaaag aaattacaca agaggattgc ttgaagccag  89580 

aagtttgaga tcagcctagt taacatagtg agaccccgtc actacaaaaa ataaaaatat  89640 

taattgagtg tggtggcata tacctgtaat cccagcatct cgggaggctg aggcaggagg  89700 

atcatttgag cccaggagtt caggactaca gtgagctatg attgtgccac tgcacccaag  89760 

ccttggtgac ggagtgagac actgtctcaa aaaacaaaat atgagtcaag ccccagagca  89820 

tgagtttgcc ttataagcca aaactggaaa ttcccatccc ctttgccagg gattcgttta  89880 

agaataaaaa ctgtgactaa ataagacaaa agggaaaatg gctggatacc agtgtcacac  89940 

agtcttgtaa gaattttcgt gtattatttc ctctctctct tgtctgtctg cttaacctgc  90000 

tctacctgct tttttgttat ataattgtat ttttgaaata aaattgagta tacatgagca  90060 

gaattggcaa taccagaaat cctatgactc agctctcttt tcctgttgac ttatcaacac  90120 

tgggaccagt cattatcagc ttagtggaaa aagacacaga agatggggaa ttaaaagaat  90180 

caaatattta cttacttcaa actaatatag acaattacat cttttatctc acaatagtag  90240 

tcaattttgc caacaagaat agaaaatact caaacctgat ggttaagtat cctttttccc  90300 

aaagcaaatc gatttcagat atgtcgatac tttgttcaat tgcttgcagt caagttcagt  90360 

aaccttggag ctgggttcct acgtgttgat gttatgtcca ctttaaatct tagagaccca  90420 

cattttcttc ccccatacgt ccaagttttt gagggacatg tggatgcctg ctagtattgt  90480 

ctatctgtct atctactaca aatatgtggt tatatcacac acacacacac acaattgtag  90540 

gccttcagag gccagtggtt tggaataatc aggaacaact gagatagtcc tgaaagactt  90600 

ggaagtctca gaagtagaaa tgatgaggat taaaagtgtt gcaggggtag aaaaaagaaa  90660 

gaataaaggc caagagggag gaaagaataa aaccaatgga ctatagctag agtttggagt  90720 

ctgtataggc aattagtggg agacaaaact ggaaagaata gtttggacag tactgtagag  90780 

ggctttgaat accagagtta aatttctgtt cgatggacaa tgggaagaca ttgatgattt  90840 

tctagttgga gaggatttga tcacagctgg gattggaagc tgcacctgtg atgggcagat  90900 

atctgtaaac actgtcttag tctgcttggg ctgccataac aaaggtgtaa acttgatggc  90960 

ttaaacagca gacatttatt tctcaccatt caggaagctg aagattctaa gatcaaggtg  91020 

cccccagatt cagtttctgg tgaaggccct tttcctggct tgtagactgc tgtcttcttg  91080 

ctgtgcccca catggctgaa ggagagacct gtgggttctt ctccctcttc ttataaggat  91140 

aataatccca ttataggagc tccaccctca tgacctcatc taaacctaat tacctcccaa  91200 

aggcctcact tcctaatacc atcacataaa gggttggggc tcccacatat aaattgaagg  91260 

gaggcacaaa cattcagtcc gtacatgtac catctgggtg tctgttatta ccataattca  91320 

aatgagagga agatctgaac aagaatgaga gtgaagcaag agcaaaaggc attgcagagg  91380 

atgaggaaaa gaagagttca cagactctga aatgttgatc cagggtgagt gtatcaaagt  91440 

gccatcactg gaattgtggt taagtggtta gggatgtttt ggatgctcag ggatgttgaa  91500 

ttcaatttaa gttatgtgac ctgagggcag aacatacaga taagtgtaag cctcaagaga  91560 

gagagattag gttcaataga aatgtactgt gagcaaaaaa aaaccacaag ccacatataa  91620 

tttaaagttt tctagtagct gcatttttaa aaagtcaaaa gaaacaagtg acattaattt  91680 

gaataatata tgtttattta acacaatata tagaaatatt attattccat tatggaatca  91740 

acatattcta acatttcagt gtgctttggc tacatgtcaa gtactcaata gctgtatagg  91800 

tctagaatgg gaaacttagg agccagttac aaactcagct catttctttg cttgggattg  91860 

tgaacccatg tttgagttgt tcctgctttt tttgctatta tgaacaatgc tgttatgaaa  91920 

cagtcatata cagtactctt ggtgcaggaa ttctggacag tatattccta ggagttgcat  91980 

agctgggaaa cagcaggtga aatagttcca atttgttttc tttttttttt ttttttgaga  92040 

cagagttttg ctcttgttgc ccaggctgga gtgcaatggc atgatcctgg ctcactgcaa  92100 

cctccacctc ccgggttcaa gggattctcc tgcctcagcc tcctgagtag ctgggattac  92160 

aggcatgcac catcacaccc agccaatttt gtatttttag tagagacagg gtttctctat  92220 

gttggtcagg ctggtctcga actcctgacc tcaagtgatc cgcctgcctc ggcctcccaa  92280 

agtgccggga ttacaggcgt gagccaccac acctggcctg aacattttta atatgcataa  92340 

gaacatcttt ttaattcaaa tataaataca tattatataa catactgtca tttgtgtgtt  92400 

gtataatata ttccttcaaa tataaaaatt tgttctcgca caaatacata taactcatat  92460 

actgtcattt ttatgttgta taatatattc cttcaaatat aaaaatttgt tctctcacaa  92520 

atacttactg aacatctgct atctgctacc tattgatcta ggcacttggg gaaaaaatag  92580 

tcccaaattc ctgctatcat ggagtttaca ttgcagtgta tattgggtgg gggcaaagaa  92640 

aagtataata ttgtacatca tatggtatta gtctggctca tccagaagga agtggtaata  92700 

ctacctgtgt tatgctgttt attaaatgca tatgaagaac tcggcaccat gtctgctaaa  92760 

tagtaaggat tctgaaaatg ctagtggcaa taataataat aataataata atatttcctc  92820 

ctttcttgcg tctacttttt ctgcagtaat ttttaaaatt agaactactg gaaatttaag  92880 

attaagatgt ttttgttatt gttgaagtgt tggctctcat ttgggtgaac ttgtggtgtt  92940 

ttctgcaaca aacatgactt tggctcattt tgagatgtgt tattttcaag cttcttaaat  93000 

tccaagaatc aagagcctga agacatgcat gttttaaaag ctacatcatg ataaatagcc  93060 

acaaatgtgg gaaaatacct aggaatgtct tgtataattc aggactgtgt tatccaagta  93120 

taaatgttgc ttgaattaat catttcaatc caacaaccaa tttattgaaa accaactatg  93180 

tgcaaagtac agtgtagagg agatgcatat gaccttacta atctttgaaa caattatttg  93240 

tccccttttc ttagataatg atgttgaaaa tgatcttcaa tcagacatca gttgagcact  93300 

gcaagacaca cacggagaag cagaaagaat gcaacttctt cttaatagct gttcgcctgg  93360 

cttcactgaa ccagatcttg gatccttggg tttacctgct gttaagaaag atccttcttc  93420 

gaaagttttg ccaggtagca aatgctgtct ccagctgctc taatgatgga cagaaagggc  93480 

agcctatctc attatctaat gaaataatac agacagaagc atgaaagaaa acacttaact  93540 

tgcatgtgca cagcttttgg taacaaatat cgctaaacct tactgtgaat ttaggcatct  93600 

ctggcatgcc actgtttatg cattgaagtg gaatttttgg tataaagcta aatggtctta  93660 

gaagcataga aaatccctat gtgccaaaag tagtgaaaca caaacaaagg aaaatatatt  93720 

aataacagtc tagtgttttt gttgagtctg ccattcgtag ctgaatatgt gattaattat  93780 

gtgatgaaaa cattttttat aaatgatctt ggtctattgg ggagcgggga tagttaatat  93840 

tccagtacac tgaatacatg aggaatttaa ccacatacat cattgaagac aagggatagc  93900 

agtttgtttt tattcaaaga cattgctgtg ttctctttca ttgcctctct cgctttctgt  93960 

cacttttttc ctccttacat taaagaaaag tttaattaca gttaaaaatg tataatgtat  94020 

ttataatatt catcgatacc attattcaaa tattgctcaa tacagcaaat tagctcctaa  94080 

cctaacaaag tttaagttta cttggattga taattaggtt tactctttat ctgaataaga  94140 

accaattcca tttgtttgaa atatggagtt tgtgactacc caaattgcta attattcttt  94200 

cttttgaata tattttacat ttctatgagc ctaaggaaga ttcatgaaac tgacctatga  94260 

gagtcgtgaa gtggtttttc agaatgctat gtaaggaccg atttgagcac taactatagg  94320 

tactctgaat atatatttcc cttgattatt caccaaaagt gttccccagt ctttgactct  94380 

ttaaattcca atactgattc caaaacaaat aaatattttg aagactcaat gaatactttc  94440 

catattttgg cctatttata taagaaagtt aataacattg acccttcaca gctcttctgc  94500 

ctgctcctca aagtggctct atctaaatat ttattactaa aatgtttttc ctacagtcta  94560 

catgaataca aacctcaata gctaagcttg acgtatttgt gcacaagtag atcactacat  94620 

taagttttgg gaattgcact tcttaaaaat gtctccccac caaacatagt aatcctgtag  94680 

ttatgcctac acaaagcttg ccatattctt tggtgcattc attttgtaaa cccattaact  94740 

ttttattgtg aagattttca tttgcagttt cttgcactgc ttttctagtt ttttaaaagc  94800 

ttgagattta tttatacttc ttgtagtaac tgcatatttc tgtgtgtgtt tagtggtaaa  94860 

gaattaattt tgataggtac aatatgtcta tcagattgat atatacacca gcctatgtca  94920 

attggggcta attattttaa atgaccatgt caaattgaat ttggagacaa aatctgttga  94980 

gagtgcttat gtaattaatg atggttctac taatctaaat tttggaaaag gtgataaata  95040 

gactatacta aaatctctct atgccataga attggattat cctgtaggtc atctcattgg  95100 

gtataagaca aaactaccta ctttttttca aaagtgcact gaaatcacat aataaagagg  95160 

ctttacctct tggttggtcc tgtgacccta agttctagtc agatagacac agaggcaatg  95220 

tgaatttgag tggcatgagc atgattaggt tattccttcc agcatctagt atagcacctg  95280 

gaatatagaa actgtctaat acatatttat tcagtgaatc aatgagcaga agtttgccag  95340 

gacagtacac attggcaagg cacataccat atgattgaag tgcttcatgc cattacagtc  95400 

catcaggctg ataaagtgaa ttatttctga ttatttaatt acagaaatat gaatttatct  95460 

tcaagggtgt agtgtcatac tgctgtacaa cacagtgctt tatttatact aataatttag  95520 

gagactgata cttccaaatg atagtggaca ttactatcac aagaatatca cttttcatca  95580 

aactgcaaaa atacagaaag gcaaaaaacc tgacacttat tcttaactgc aaattaaatt  95640 

cctgcccagg ggatatattt taggagggga tgaatggcag cttttgtgtt ttttttaaca  95700 

agcttgaaag ggaggtggaa aacaaagaaa ttatgtaaat ggcatatgag ttttattatc  95760 

taggcattcg ttagtatggg gaaacctgat aagaaatgaa aatcccaaat gatttcagcc  95820 

ttttcatgat ggttgaggtt agatttcaga gatgtacaga gactagagcg gtggttagaa  95880 

agaggatata tgtagtcaca gcagaaagac gtgtctaagt ttaattttat tggctttcaa  95940 

gttcactcat gtatacttag tttgtccata catatgtcta atcaggaaaa atgcatgtat  96000 

agattatgac aattcctgaa ttttgaagta ttggttaaaa gacaattaaa ggccaagaaa  96060 

accatggtgg aagaagtaag cgaatgaaat gtagaaatat atgtaaaatt agcaagtgtc  96120 

aattttacca agtagtgttg attttccaaa caatgaattt atatactatg ctgagtcaca  96180 

gagaagaatg atcacatgtt acttaatgag agcagtttac ttttcaaata aaataggtat  96240 

gatgaatgtc ttaaaaatat cttgaagttg aagaaacaaa aatgagttat ctcaatattt  96300 

accaagttaa cctagtgctg tatatatccc aagatatttt aggtaaatgt aagtgtttaa  96360 

tcatgccaga tttaaactag tctgaaatat agggtataca tatatttcta cttacatttc  96420 

tttattttat gaaatatccg accatgttgc agaaaataat gcaaaacctc atgtaagtta  96480 

actatgaaag atcctgtgag cacattggca ttgagtgaca gacaaactaa aaactggcaa  96540 

acagtatttt aataaggggg tcactctgtg gcagtattct aatattggat tttcaagtag  96600 

attaggcttt ttatttattc aacgcttttt ataattttgt tctttttgac tccaaattat  96660 

tggtcagctt tcaaccttct ccacatcagc aatcactaat agttcttttg gttgagatca  96720 

actcagaaaa agaaaataga aaacttttgt tctttgaaat tttagacatg cataatatct  96780 

atttattttc ataatttaac cccaaaagct tctcctgcaa tacacaggat tctaggagct  96840 

gaatgacaca gggagactac agagtattta ttattacaaa cacataaaaa gcctaacttg  96900 

aagaattaaa atttctattt tttatctgta taacaagtac aaaccatcaa caatgacaaa  96960 

ttttcacagc tgcttgttta ttgcttgttt tatatgttta catatctcaa aatctgttaa  97020 

aactgaggtc taaaaaatgt gcagaattgt gcaactgtgg cctagtccat aagacttttc  97080 

tgagttgcaa caaagtgctg acaaagtgac agatgtctgt gatgtttcat gacataggtt  97140 

atgatcgagc caatttacaa aatttaataa ccaacctaaa ctcacataca tatttgttaa  97200 

gaagctgaca tcagttcagt attgtaagga aactaactag gtggtgatga tgataaaaga  97260 

attagggaaa atattttatt tgatatattc ccttttataa ttcctaaaat gaagattcta  97320 

tttaagggtt ataatttata taagtttagt catataccat tacattatga taccataagc  97380 

agagtgcatt atgattctct agaaatataa ttcaatcaga tatgtattat atttatttat  97440 

gtcacacatt ttctttactg agaataaaaa ttatcttatt ttcagaagct ttgtatcaat  97500 

cagtttcatg taataagcaa cccagatatc tactagatta tgtatttctt catttgaaac  97560 

tacactgttt tctcctagtc cccttgactc tactgtgctt atccattctt tcacagaaag  97620 

aaagtaacag acataattcc tgttgatgag gctgggattg tttttaagag gagagataat  97680 

aacttcatat ttttaaagtg ccagtagcct aatatgtgaa acagatcaga atctgttgtg  97740 

tagtaagtct gctttgttga agaatttatt atgggagtaa agataagaag gaaagagatc  97800 

accatcagaa acaagtcagc cttttcatgc ttttttgagc atttttggag atgattccac  97860 

ttctcaagtt attatcattt gtgcatctct tcaatgctat tgttaaatgc tttagaatta  97920 

gaatattttg atcctttaat taaagtaagc caaacgtcta ggcaaaaaca gccaatcatt  97980 

aaactttaat agtaattcaa atatagattt ctcatacagt tttccatgtc tgtagaaatc  98040 

aaagttgtaa tgttaagcag agggaaatgc gtgtgattta ctaatacact tcaacgttct  98100 

acttttgaaa ggatactcat gtgggtgggg cagagaacat agaaaaagat atgatggaaa  98160 

acctgtccat tttctacctg ttaaccttca tcattttgtg ccaggccctg gaagcaaaga  98220 

gaggaaggga ccgactgcat ttatctttga acacttgagc atcagtagta ctactgagtg  98280 

gccaggggtc ttgtctgtca aagcaaatga taagttcact caggccatta ttgactgctg  98340 

aactctcttc cttcccaact cttccttgaa agagaaaaaa atactttgcc ttcttgctct  98400 

ccttatcaaa tgtttttgta caaatagtgt aagcctgttt aagcaaacca attaaaatag  98460 

gcactgatta ttttgatctg tttgtaacaa atgaatgtaa gtactattta catggtgtgc  98520 

ctaggaggag ctgaaatcat tggcacttta atccatattg taaagatcag tatcaaaagc  98580 

atagtgttct tcacctctcc tcctcagcat ccatctctat atacttgatt aaatggaaaa  98640 

gtctctttta tcacctctat gtaaagtttt atgggtagtt atcgtcagtg tatttaaata  98700 

tatcttctag tatgttttaa aggctggtct tcaatactgt ggagacaaaa aataaaagag  98760 

cgtatgaaaa gtacgttaga cttttgctgg cattcaagtc atggctagtc tgtgtattta  98820 

ataaatgtgt gttatttatg tcgtgtttgt caatggaaaa taaagttgaa tattctgaaa  98880 

tgtcgctgtg ttttcttcct gatgtcaact cacgtcagga atactttacc tataactatg  98940 

ttaagtattt tgctgaaatc ccatttgatg tgctttgtca aataatagca caatgtaatg  99000 

caacagcccc atgctatctg gaaaaattag atcattttgt tttatattcc ataatcatgt  99060 

gcataacaaa ttattgttga tttaatataa atatgagagt tgctcttttc cgattttcaa  99120 

catgatgttt ctttgtttta ttatctcaag attattgttc ttaacacaga gtgcatttat  99180 

aaattattgt aagcttagtt atttcccttt cttgtggatt ttggtgtaat ttacaggcag  99240 

ccaaaataag aattgtcctt gctcatagta caacccttta attgacttgt gcctgagttt  99300 

tggtgtgagc tgagtattgg tggttatgaa tactgggatc cccagctatt tgttcatgta  99360 

cttattgagg tcactattgg tcttccttct tcaatgaagg gagaagctct gtcaaatgta  99420 

gactgcaaag tcaagctcat taaaagtatc cctctttctt cgtgagaaaa gatatccaag  99480 

gagaattctg tccctggttc ctcccatgtg ggggttctag gcctaggacc agatcttatt  99540 

gtctctacaa tcttgattct ttagtatttc aggataggca gagttttgtt aaagtataca  99600 

aaaatcatag ctagataaga gagataacag aaataagttc cagtgttcta tactcctgta  99660 

ggatgactac agttaatgct aatatacagt tacaaatagc tagaaggagg ctattgaatg  99720 

ttcccaacac aaagaaatga taaatgtttg agatgatgat gtgctaatta ccctcatctg  99780 

accagtatac attatatgta tcgaaacatc gctctgtgcc ctgcgaatat gtacaattgt  99840 

gattattaaa ataaatacat aaataaaatt taaaagtcat tatgactact atggctatgg  99900 

ctcacccgaa atttccacca tcatgctggt aaacctacag gccatggggt gagacattcc  99960 

ccagtttcat gtcctcagag ggcatggggc caaatgtcct tggggccagt gtgcttgcta 100020 

gtactagcct tgagtaaatc cattctggat ggatgtttgt catggagaat ttaagtcact 100080 

tctgcaggct tgctctttcc ttcaacatat atttattgca tacctattaa gtgccaagct 100140 

ctggtaggta ctaagaccca agaattaata aaaacagcaa gctctcagtg aatttataac 100200 

ctggtagggg aacaggaaat aatcagagct gcaattagag taagcacatg gtatcatgag 100260 

aatacatgga aacgtgatgc taacatggga ggtattcctg tagaaggtgg catttaatcc 100320 

tcattttggg gaaaggaata ggtgttaacc tgtaaaggaa ggacattgta ggatattttt 100380 

tcacttcact ctgtccaaag cattacagtt tccaaatctg tcaaatggac taaactttag 100440 

tggtcctgtg ggtagtgtgg ctctacatag atcctttcta tataacctct cagggtcatc 100500 

aaagtggcat ggctttaggg cagggtttct caaccttggc actattgaca catgggacag 100560 

gtaattcttt gttgtgaggg ctgtcctatg cattgtaggt tatttcccaa tgtccctgac 100620 

ttctactcat gagatgccag caatacctct ctgatgtgac aatcaaaaat attcacagac 100680 

attgccaaat gtactatggg ggacataatt gccctcagtt ggaaccactc cttaaaagca 100740 

agggccaggg ccactaaaca ggtgctatgt acccaagggt ttgaggggtg aggccatctg 100800 

tggggccttg gtccacatag gcactgttct ggcatttcct gaagcagcag gtactagaat 100860 

gccagtttgt gtctgactgc acaaaaatgt ggtgctgcca ctacaacaat gcctggatca 100920 

ccacaggccc tgatcagctt ccataatcac ataaacctat tcacagatga ttaggcacaa 100980 

tttcttagaa agtatcatct ttctattgat gcctccaatc tctattctct ttttgataaa 101040 

aggaattagg gtttgtatgt ctctcaaagt gatacctaaa gtgagtcttt gtctccaaag 101100 

acctttaaaa aatctgttat aattctacat ctttaagtac acatttccag acaattctct 101160 

ccgaaggaga aaactaattt atcaaactat ttccttaaat tagatgtttg catatttagt 101220 

ctgtataaca aagctgcaga agcttcattt tatctgaaag atgattttta tcaaagaaca 101280 

aatattgggc aatgtctctt gatgagcctg tgactttctg agttcatgcc agtcttcaat 101340 

tcctcaggtc tagagttatt atcatacatt ttgataacag agttcaagtc atgatctcta 101400 

taactgacac tactgaaacc tattgtttgt ataaaatggg aagatgggtt tacctaccac 101460 

actgaaaatc aaagtctgat aaaaaaatac aattagaatg agggacctaa tctgttaacc 101520 

ataagtttct gaggccaagt tacaaaagac tatggataat cagtgtttat gcataatatt 101580 

cttatgcaat ttttaaaaag aaggctttga atataacata caaggttgtt tgaatctgat 101640 

tttgcaaaga acattgagag aaaataattc tgaaatccac aattgaggct gttttaagtg 101700 

atatttaatt agaaagaaca ttggttctta attattttag gatcaacgac ccttctgaga 101760 

aattgatgat aggtatgtgg tactcccaca aaaggtgcag aggatttttg cacagtgtca 101820 

gaaattgtac agacctgccg aagtctatct atagacctct tcggcattta tgcccatagg 101880 

ttaagaaatc cttctgtgag agcctctatg atttaaggaa ctgcaaagct ttccacgttt 101940 

ggttaggaaa ctcaaaccta aaactggaac taagtcaatg taattacttc ccagtgaatg 102000 

ccaaaattcc ttgacatcta tctaacgata tgtccataac agtaaatcaa tgtaactgga 102060 

ggtagaatta ttataaggaa ctgcaatcat ttttctctaa aagttgcaat catgtgatga 102120 

taagaaataa cacaatttga tctgagagga gcaatatagg ttactcaccc caaaacaggt 102180 

tgaaaagtga aagacccatt taaaaaaaat attacaagtt atccaaagat gcatttgcct 102240 

tacaataaag atgttgtttt agttttgcct tgtgctggcc caacaagaga gatttataat 102300 

gtagctattt aaaaaatcaa taaaaatgtc atctacccac ctccctggaa aaatgtaatc 102360 

tcctatacac aagcaagcta catggttaaa atgtaacttc atgatactag gatatatatg 102420 

tagacacata tctatttata cttctatagg cactaaattt gtgcattgcc attcagagtg 102480 

caagtggcag ggatgacctt attgattgaa cctttgaata agaaagcaag gcatgcagtc 102540 

acagaccgtc ttacaaatgt ataattaata atggtttaag ccaactttta aagctattag 102600 

tagaatctta ctgatgttta tggtttgcat ttctctggag ggaaaaatgc agagcaatta 102660 

atgacatgta tttttgcatt tgtctttcct tattaaagaa gatgaaaatg gaatcttaga 102720 

gcattgaagt atttgtcaat cataaacagc tctttgatac caaagcatcc tacattctgg 102780 

atgtatgtgc atgaattgga cagatacaca gtatgtgcat gacattacaa gttgatttta 102840 

atgagtcagc agtggtctgt gagttggagt cttcttctta ggagatccag gaggagctgt 102900 

ttttagagga aaagcaattg tcctttgtta gtttcaacat ttcttgacca tttaaatttt 102960 

ttgcccaacc cttttatttt aagaattaac gggacaaaac gggtttttac ttgaaatatt 103020 

ttggagaaat aatattggca tatcatgaag tgtaatcact gccttaaatg ttgggcagct 103080 

ctaattagat atgcatgact cttatccctg tccgagattt tctcacacca tgaccgtttt 103140 

gaatatccct gtgactattc attcagacta ttaataatcc aaagctgaac taattcattt 103200 

attttggcca tatgtaattt aaaatatttt aaagtatatt ttaaatacag tcattttaca 103260 

aaaatgctct ctaaagtttt gtgtgtcata atgaaagaga aaatgttcta cattggacaa 103320 

ggagccagaa caccttggtc gaattatttg atttgttatt tactggttat ttgcccttga 103380 

caatccatta aatgtctctg aatcaacttg aattttctta tcagcataag attgttacaa 103440 

ttaaatgaga taatgaaaat acagactttt tttttaagag atagggtctt actctgtccc 103500 

gaaggctaga gtgccatggt gtgatcataa ctcgttgcag cctcagcctc ctggcttaag 103560 

tgatcctccc acctcagcct ccccagtggc tgggactaca ggcatgcgac acctcactag 103620 

gcttattttt tttatttttt attgttttta gaaacaggtc tcactgtgtt gcccaggctg 103680 

gtcttaaact cctggcctca agcattcctc ctgtcttagc ctcccaaagt gctgggatta 103740 

caggtatgag gctttgcacc cagtaaagac acttgaaagt gctatacaag tggttagtgt 103800 

tactttgtta tattcatttc attaattgaa caatattaga aaattaatta tgattgttct 103860 

catctcatgt ttactacaga cttcccagtt tagtattggg caatcgcaca ttcaccagaa 103920 

cacacaagtg acgttagaaa gctggttctt gtcacagaca ggatgtgtga acttgggaaa 103980 

aatacacagc ttcttttagg cttagtacct catctgtaaa ataaggggat gatatttcta 104040 

tgtggtatct tctcactgaa aagccatgat tctcctttct ctctggaaat gtcatgaagg 104100 

tggtcttgtc agctaaacac agataagctt ttctcttctg agtcctggaa aacagctcac 104160 

aggaaaactc taggagacaa aaatagcaag actcaaaagt atagattctt tttttctcca 104220 

aaaagaaatt tcaggttccc actctttctc ctgaatgaga tggatttctt ttctcaacca 104280 

aattgcaaaa tccttgaata caggtaccat gtcttccatt tgttaagatt ttctgcctcc 104340 

ttttgcttta ctcttcatcc taactgctaa atcctatgcc tttaattgtt aaatgatgga 104400 

tattcattta tttgtggcta aggaactctt gtaacaaaga gtaagttaca tagattttta 104460 

tacacttgtg cttatttgtg tgtgtgtgaa ggagcaagag agatatctgt tatacctcaa 104520 

atgtgtattt cttttcttaa gttttttcat aaatttttat taaaatacta tgtgcatctc 104580 

tttaaaaagt caaatagtgc tgaaaggctt atcatgcatg aaacccacag tccccattct 104640 

aaccctaccc ctagaccacc tgctttccag tggctactcc tttcagctta ttttttcaat 104700 

gttttttcta gcatatgaca ccataatttt aaataatata ttgttatctc acactcaatc 104760 

aactttatag acattatatg ctgattttct attttgctgg atttagctct ctcctcaccc 104820 

attctcccat tatagttata actgactttc attaaatcaa cattcaatgt ttgcattttc 104880 

atgataatga aaatatcctt cactgaggaa tcagtagtac tgtaattatg tttcttttct 104940 

tgaatacatt tctctttttt tctagagtta cgaactcatc aagttttgaa tttgcttaag 105000 

tttgctttgg aacagtggct aaatcttaat agtcttccaa gtgcccaaac ctatctgata 105060 

atctttaccc actttgggag tctaacattt ttctggtttt ctctgctatt catccttttg 105120 

cctcttttat ttatattgat agtcctttgt ctagatccca tgtcttcatc cttcttgaat 105180 

tattcactca ttttgaccac atctgcttta aaatgagctt cttaatagta aaggatgtta 105240 

agtaaccaaa ctcccagaaa tggaaagaga atgctttcag ggacacatga acactaacaa 105300 

cgttttaaag aaatttgaac tggtgataat gaccatagtg gcagatacca ttttatgagc 105360 

acctacactt ttcgtatgtt atcaaattct catgtcaatg acagcaggta ggtgttatca 105420 

gcactttcca gataaggaaa ctggggtttg tggaagaaaa gtcacttgac caaatacaca 105480 

acagttaatg agaaataaag ctggggttca cacctgactt gggtttagaa tataatcatg 105540 

tgttatccat gagcaaataa ttactactgt gattagtttc agaagcttca agtttatctt 105600 

cgagggtttg tttaaaaccc catggaagaa aggctttgac tctattatca atgtctggac 105660 

attttcaaac caccagaaat aattttgggg agcagtggtg aggcagcttt tctaagagtg 105720 

ctgattagat taagcaaaca agattctcag caaaaaatgt gaaggtccat atgtccaatc 105780 

taggtgtgtg cacatgactg caaacattta gatccttcct tgtttgatcc aggaccactt 105840 

ctgcagtgga gaaactattg gtttcctggc agcagatggt tgtacagaaa aactgcactt 105900 

ctacttccac acaggcctgt ggtttttgct aaagccaaga gtttatcaca atttgggtta 105960 

ctaagaatac atctcttttg gccctattgg cttttgtctc tttttttatt tttcctttta 106020 

cccgtcctct cggacttgta atttgggaga atgcttactg aaaagcagaa gatacttgtg 106080 

cttcctagtt acagaggaac tcctaagaga ctgtagaaaa ttcaggacct agggcagacc 106140 

atttgtcatc agtgaaacta ttctgattat catctctccc tgcttaattt tgaaatttgc 106200 

tttagcttct tctggtaaaa tacaatgcag tttgagtgga gcacattttg tctttcagaa 106260 

agaaaaattc ttgccccctg tttctgagtt ttccatccct ttctgctaac aggtgaaatc 106320 

tatttgatgc atttgatatt ttattcattc accagttttc tcttcaactg actgctctct 106380 

gatttccaca gaactgatca gactgattag aactgtgcaa aacattttgt tcaaggaaac 106440 

aaaatctcag cgtctccaaa ctctaattct attattatca ctaaatgaat tcagaatgca 106500 

acttatccat agatatataa agtggaaaaa tttgtacatc ttgatgttta tctttagtct 106560 

tattttgtac attgtctttt gaatatttca atgtaagtgt gacaatagtc aacagttctc 106620 

aggcatctct ggggtcaatt gacatttatt tgaatgaatt caacccgagt agctgggact 106680 

acaggcgccc gccaccacgc ccggctaatt ttttgttttt tggtagagaa ggggtttcac 106740 

cgtgttagcc acgatggtct cgatctcctg acctcgtgat ccgccctcct cggcctcctg 106800 

aagtgctggg attacaggcg tgagccaccg tgcccagcca cacgccagat tttaaatatg 106860 

gtacttatcc accgtcatca taataagcac catcgtcgtt ccctgtgcaa aattttcata 106920 

gatgtatcga gattcaagca aaacagtaat ttatttctga gtacctcagt tcatctctag 106980 

ctgtaaagtc acaaacagaa ctaccagaga atttccggac tgtgatgtat ttgagaaata 107040 

cacaattaaa aggggcatta aatcaatttg aattaggatg gaagtgattc ttttcctctt 107100 

agtacttgga ttcacagcag taacaacttg gttcttagtg gagctgttac ttcccaagtg 107160 

atgactgtgt ctccaagtag attttgacca ccaattaaat gaatgatttg ttgatttatt 107220 

tagtcatatt cacattttta atgagcttct atcatgtggg tctaggttgt ggggacattg 107280 

aggtttatca cttgcagatt tcagatttca gattctctca ttcttcagag cgaagtctca 107340 

gttttcactg attgcattta ggacttaaat agctttccca aagtgtaaat cgctctacat 107400 

tttctttcat tgtaattaga atatatattc atgtataaaa tttaagcaat acaggaaagc 107460 

acgaggacca aagaaaaatt ccctatactt caccactcaa acttaatcat tgttatggtt 107520 

ttgattaata ttctttcaaa tatttgtctt tgtaaatttc ccttcaaacc tgactgcatc 107580 

taagaaccat ggtgagattc tctcaaatgc atgaaggagt gtcacattaa atagagattt 107640 

atttcatatg ccctgaaggg cggactaaga agctacagag agaaagagtc tgacttaatc 107700 

tagaaaggtg ctaaaccaat gtgccctaag gtggcagggc tgaccttaag caataatgag 107760 

ttccctgtca cttcaaatat tcaagcacat accagaaaac cactagggag tttgctgtag 107820 

atggatggaa tacaaatatc ttctttaagt cttcttccaa ctcaggattt tatgattcta 107880 

tgtctcaaaa cagtcatact atggctacaa tattggaatt ggtgtaaaag acaaagattt 107940 

gtctgaatat agctgctgag cttagtgttc tgctttcaac ctcttcagat gtggcttata 108000 

ttctgcttta tgtgtcacta aatgcattgt tgttgaccct aatctcaaag ctagaatttc 108060 

atgatttcta tgttcacttt atcagtttac aacatttttg gaaaactact cataaaacag 108120 

caaaaatgtt tttttaaaaa gagctacagc aattactttc caataattaa atcagaatat 108180 

ctggtggtca ttaataacaa ttataattgg attattggat tgacttcatc gaatatgaaa 108240 

gtctgccaac aatatgaatt tgatcaaact ctgcttatta tctattctga tcattttttg 108300 

ctatgtgtaa aatatacaca tatttcagaa gaataaatct atcatgaata acaatcacca 108360 

aatttttgta caatattatc taacctgtta tgtatatatt tttaagtttc ataaccaaga 108420 

gaagagacgt atactttatt tatttactta ttttattttt attttttggg agacagtctc 108480 

cctctgtcac ccaggctgga gtgcagtagt gcaatctctg ctcactgcat ctttcacctc 108540 

ccaggttcaa gctattctcc tgcctcagcc tcccaagtag ctgggattac aggcatgcac 108600 

caccaagctc agctaatttt tgtattttta gtagagacag ggttttatca tgtttgccag 108660 

tctggactcg aactcccaac ctcaattgat ctgtcctcct cggcttccca aagtgctggg 108720 

attacacgca tgagctacca cgcccagcca agaaatatac ttcaaaacat agaaacaggc 108780 

caggcgcagt ggctcatgcc tgcaatccca gcacttttgg aggccaaggc gggcggatca 108840 

cgaggtcagg agatcgagac catcctggct aacatggtga aaccccgtct ctactaaaaa 108900 

cacaaaaaaa ggctgggcgc ggtggcgggc gcctgtagtc ccacctactc cggaggctga 108960 

ggcaggagaa tggcgtgaac ctgggaggcg gagcttgcag tgagccgaga tctcgccact 109020 

gcactccagc ctgcgcgaca gagcgagact ccgtctcaat aaataaataa ataaataaat 109080 

aaataaataa ataaataaaa atacaaaaaa attagccggg catggtggcg ggcgcctgta 109140 

gtcccagcta ctcgggaggc tgaggcagga gaatggcatg aacccacgag gcggagcttg 109200 

cagtgagccg cgccactgca cttcagcctg ggtgacagag ggagactcct tctcaaaaac 109260 

aaaaacaaaa tagatacaaa tgattcagta aatgtttagg gaagatttta aagtttaaaa 109320 

taattataag gaaccaatac cattacttaa acagggaagt ttttttaaat caacagtaaa 109380 

attattctta aagacattat tttgtctcag agagtaggat agaatgggta tttttttttt 109440 

aggtaagtca agcctaatta ctacttaact attcaaccta attcttaaca ggattagaaa 109500 

gagttacatc tcttttaaag cacaaaaaac cagacactca catctttgtt ggaaatgctg 109560 

aaatttctgg catcattaat tgttccctga agacgtcatt tcagtgtgcc actgtaaact 109620 

ccaaggttta tagcatcatc aataaggaag gcaatgagta gccttatgga agggatttgg 109680 

ggatttaaag acataaattt gaagtatggt tcttgactta ccagctgtgt gactgagtag 109740 

gttttaatct ctttcagcct ctgtttactc atctataaat tggagataac aacacctatt 109800 

tcacaagata gcaaggaaat gagataatac gtatatataa agcccagtag gaatgcaatc 109860 

atttatagac aatattaaca tcaaataaca ctaatttcct ttccagaact atatttagga 109920 

gttatattag ttgaatagtg ataaatgtaa aataatatta atagtgaaca cttataaaag 109980 

tattttgtac tttctaaggc attttaccat ctgtagtttt atttgatcaa atttttagtt 110040 

agctagggag tgttgttatt attcctattt tataaataat taaattgaga ttaagacata 110100 

tatcaaaaca tcatgttatt actataattt ttacttgtca attaaaataa ttctaaaatt 110160 

tttttaaaga aagactaaga ctaggtgtag tatttggacg ctagagtgaa acttcagctc 110220 

aaatatcact ttcatacttt ctttagagtg agtttcttac tccttctaat ctcatttttc 110280 

tcatttgaat agtggagata gtagagtgtc ctagactatc tatttcaaga gcagagactt 110340 

agagtgtcct ttactacttc cccactgccc actgtacaaa gcccaaaagc tttaacttgt 110400 

tcaaagctct cagtaaacca atcccaatct accattccaa tttttttctg gcaacactga 110460 

taccagcctt ttttgaatcc tctccccaaa cacattatgc acattcacaa ttctgtttct 110520 

agtgtttact ttgcttaaat gttaatttca atgaagaaaa ttctgctcat tcattaaagc 110580 

ccagctcaaa tgacacctac cctaagagtt gtttccttat gcctgattca gaattactga 110640 

ttccctcttt tgtacatcca taaacacctc atttatgcct cggtgattac ttctcactgc 110700 

tctacttata ttacagtgag ctgtgggtga ttctagctcc cccactggat ggttaccttc 110760 

ttgaatgaaa gacacatcat tttaatctta gtgtcccagt ccctcccact tcctctcctc 110820 

cccagacctt cagcttccaa gaatgtgaag gctttgaatt atagatacac agtagacata 110880 

gaaatactta ttaaattgat ttaaatgacc aaaaaaaata gtacaaataa aaaaaaggca 110940 

atgatgtccc agaagaggtt ttagtttata aaaattaagt tttggctggt cgcaatggct 111000 

cacgcctgta atcccagcac tttaggaggc tgaggggggt ggatcgcaag gtcaggagat 111060 

caagaatatg ttggccaaca tggggaaacc ctgtctctac taaaaataca aaaattagcc 111120 

gggcgtggtg gtgcacactt gtactcccag ctactccgga ggctgaggca ggagaatcac 111180 

ttgaacccag gaggcggagg ttgcagcggg ccaagatcgc actactgcac tgcagcctgg 111240 

gcgacaagag tgaaactctg tctcaaaaaa aaaaaaatta aggtttacag acttaccaca 111300 

ttgatagata cagcatacac tacatgtttc cgtaaatagt taactataat tagggactga 111360 

aattagagat aatggcatcc aaacttttgg catgcttgct attcacaatg cctctttttc 111420 

catcccggta aaggtccctt ggtgtcacca ttggagagaa tattaaattg aatgaactac 111480 

tagtcttagt gggtgcaaca cttcttacgt tcttatatta agtttctgag gtgatatgaa 111540 

gggaagacag tttttgatta attcagatgt ctgcaatggc cctagctgga gaatggccag 111600 

gctgagaggt gagcggccag gctagaagag agaagggtag ctgtggttgg caggaacaga 111660 

gcaactggca aagagcagag cagcctttgg ccgcagggtc taaacccaca tccttgctcc 111720 

cagccctttt ggtaacacag ctatgaagtc agaggctgat aaagagtgaa aaaacacttt 111780 

ccttccaaga acgaagagcc tttgaagaaa acttctgacc acctcctttt ggggcacaag 111840 

gaagttgaac agggttttga tctgttcaca tttagaaatt ctttttgctt cctgccatgt 111900 

gttcatatca ctagactgca gtttctccat caattcttct tattgttcac tgcatccctt 111960 

attctttcac tcactcggtt tgcattcagc ttctaatttc tgcttattac tatacttaac 112020 

cacagtgggg atgcaaatgc cctcgaggag caaagaatgc aagtaacaca tctcaaagac 112080 

tggaaaactc caaagcacac ctgagcagcc tcccagtcat tcctgaaaat ctttcttctg 112140 

agctctccag agactacaga gctttttgtt attaaccctc ttcacctaca cctcagtttt 112200 

gttaatgggc tgctgcaaaa ggagagccta acatggttag acattttagc ctaactgtac 112260 

aaaatgtaga cttctgccca agaccagttc acttttcaat acttggtgaa tttctcagaa 112320 

aatgagtata gcatgattcc tctagctttt agggtgtcat aagctctatc gcacagacat 112380 

attcacccat gtcccatgta tacacatgcg ctttataaag caaaccaaag acccaggagt 112440 

cttgcgctgt ctctctagaa gttttccctt taacaaggac accatctgtg atacatctgc 112500 

tttcttagtg ggggatatgt aacaaacgta ggacagtaat actgaaaaac aaatggttta 112560 

aagatgaatg tgttccacta tgcagaaaaa gagaagtgag gttcataaga gaatatctgg 112620 

aagtgggaag aaagtaagta tatccagatc tatatctaga tatacttgtt agaagagggg 112680 

ggaatttaac attgagggac ctcatatcta attttattga agaagaaaaa caaggttaat 112740 

tgaatttatt ttcaagtatc taatgaaatt aatctcaaaa agttctaccc agggcaatgt 112800 

tgttataaat gttttgggtc ttagttatac tgttgctata gtattcaaat tagcatggat 112860 

gatcattaat caaatgcttc gaagatggta gtcactgtgc taagtgctta gaagctgcat 112920 

ttctcatctc tgcttctcag agggaaatat atagtgtagg gtgaggcttt aattagtatc 112980 

ttttatttgg ttgagcccta aaggaaatca agtaaaatga tgaaatcgat gtccttggtt 113040 

gctcaagtgt tgcctctttt ctctctgtaa cactaggctg tttccacctg agtgcatggt 113100 

agagaaaaga gcacattttg agacatgaag ctgctaggtg tgtctacaca attggttaca 113160 

tagggtcctg tagctgaaag aaacagtaga gatcattgag tcaaaaggag ttcaactggt 113220 

tcaacagagc gctatcttta gtaaggggtg aagggttcaa ttttgaacaa catgtgggtc 113280 

gctataacag cagcctaggc tcaatatctc ccttttatct gttgtgtata tcaggctttt 113340 

aattaggatt tcatttaaag aaatcgctct gcttccaaaa aaacaaggat atcaaccaca 113400 

aattcagttc aactgagaga gtttaagtgg cttgttcaaa gttgcatagc tccttagagg 113460 

cagagccagc tctagaactc gggccttctg actcccagac taacttcagc cttgatgctg 113520 

tgtttgacag ctatctggat gaataaagag cagggattct ggagccagac tacttgggtt 113580 

caaaccccag ttcatttact tactagctgt gtgactgagg gtaaattact caccctcctc 113640 

agggctcagt attttcattt gtaaaggtat tagtactttc ctctgggatt actatgaaca 113700 

tcaaatgagc taaaatgtgt aaagctttta gaaaagtgct tgatatttag tataaccaat 113760 

taaatatagc ctattattat tgtttaaagg gtttccaaaa gctttcctaa ccttatagga 113820 

tccaccataa gacctataat ctaagaattt tcatttcttt gagcaaggac acaaaaggcc 113880 

cttcttagaa agtaaatgca ttatctgagt aataacacag taaatcactg tcactctctc 113940 

atatctcata aataattatt tccattacct ctagccactt agtaaggcca tagaggaatg 114000 

ggacatagaa cagttaagcc ttaatgatga gttagagtta ggatttcttt ggaaaaacct 114060 

gggaaagaca cgaagggctg ggagggaacg aatctcaaga gaagacagac acctgaagct 114120 

attgtagccc atttcaaaat tctcttctgg gcccacctca gagactgagg cacggaatgc 114180 

atctccctgc agttcccaga aaggactggt gtcagggtct ccttgtgctc actccctaga 114240 

aaccttccct ccctgtctca ctccacatat attctctata ccctagtatt ctggctcaga 114300 

gagtgtaatg aaagtagcag tggaaaatta aagaaagaaa gcaggctcat aagggaagac 114360 

tgagggtttg gagaggagag gataagagag gaaatgtctc accagtcagc ctcggggata 114420 

gtgggcagag agtgagtagg gtttccaaga aaggagcagt aaaaccaaag tgtaatgtgc 114480 

acaggccagc tcctctttct ccatgtttcc ttggactgtc aaaagtgtga gggtagggcc 114540 

aagccctgag tatatatcct tgcagagtgt cttgtttttc tagattgtat tggagagtgg 114600 

gagttctaat ggtatgtgtg tgagtgtctg agagagaaga attgagtgaa gtttaaggtt 114660 

aggtgacttt tattattaat caaatggaag cccaaggtca atgagaagca cattggaagg 114720 

aagcctatga agtgaatgac gttcagaagg cagttctcaa caataaattc aaataacctg 114780 

ctttcttttg agcaagaaat taaatgttac cttcactatt tgtgaaacgg aattgtagca 114840 

tttttcattc tgctccaggt aaacacagat aatctagtgt ttttattgcc attaatatta 114900 

atctccatat tatatgattg tggagtggta catatcagtt agttaaatat tttagttcca 114960 

gccaggtgca gttgctcata cctgtataat ctcagcactt tgggaagctg aggtgggaga 115020 

attgcttgag cccagaaatt caagcacagc ctgagcaaca ctgtgaaacc cgatctctac 115080 

aaacataaaa attagccagg tgtagtagtg tgtacttgta gtaccaggta cttgggaggc 115140 

tgtggttatg ccactgccct ccagcctggg aaacagaaca agaccctgtc tcaaatatat 115200 

atacatgtac atacatgtat ttatatgtgt acatacatac atgtatataa aatgcatata 115260 

tgtgtatata tatgtataat atatgtatat atatattata cattgataca tatgtataat 115320 

agatataata tgtattttat atatatatat atgtgtgtgt gtgtgtgtgt gtgtgtgtgt 115380 

gtgtgagaca gtctcgttct gtcgcccagg ctggagtgca gtggcgcaat ctcagctcac 115440 

tgcaagctcc gtctcccggg ttcaagtgat tctcctgcct cagcctcccg agtagctggg 115500 

actacaggtg cccgccacca cgcctggcta attttttttt gtatttttta gtagagaggg 115560 

ggtttcaccg tgttagccag gttggtctcg atctcctgac ctcgtgatcc gcccaactcg 115620 

gcctcccaaa gtgctggcat tacagccgtg agccaccaca cccagctgta tgtgtatata 115680 

tattttcaca tatgtacaca tacatacatg tattgtatat catgcccaga agcttgatgt 115740 

gtatatacac acatccatac atgtatgtat atattttcac atatatattt ttacaaatac 115800 

atgtatatat gtgaaaatat atatgcatgt gtgtgtgtgc gtgtgtgtgt gtaggttcca 115860 

ttgactggta atatgttttt gataattcag aaggcacttc aatattttgt aagtccaggg 115920 

gcatttttac taccattgat aactggccaa tactatcaaa gtaaatgctg ctatgtgaaa 115980 

tgtctggatg cttgattctg ggttgaagaa attttactgc atatagcact tggatttcaa 116040 

tcagcaagtg acatattcta actgcacagc cttctataat ttgttaataa atttattttt 116100 

attttcagtc tcagtccaag tgcttctcag ctagtttcaa aataagcagt tatgagttag 116160 

ccaaatacac attctcaata atattgtttt agctaaaaat atttgcatac atgtagctca 116220 

tgaaaactca gacatcataa aaataaaatt atcctgcaga accatgaaag tgagaaggta 116280 

gagaaaataa gttaatgcag gcaaaaaaga gtccctttta aaaggtaatt attccagaaa 116340 

actgaaaaca gagtgcttct cccagtgaaa cataagtgag caccaaaatg attttagtaa 116400 

caacaataac actttgacat acatttattt tatttgatta tcccaacttc cctgcgtaga 116460 

aaatggagct gctgttatca ttatccttat aaccaagctt tataaaattt aagcaacttt 116520 

ccaggtctgt agtgagttaa gtaagcttca agcattctga tttctgttct gagcgctttc 116580 

ctgtgccact atctgtattg taaacccggt aggagggcag agcagatttt tattacacag 116640 

tagtatgata ctgtgtcacc tctcctcttt aagaatgtca aaatattgta caagttttgg 116700 

ggggggaatt acatgcaaac aatttgaaat tatcatggaa cttctgggca tgatacacaa 116760 

taaaaccagc ctcctcatgt taactcccaa agccttggtg actgaacaat ttaggtaatt 116820 

aacttcattt taggctagct ataatgaaag ctcttggttt cctttataag tgtggcttct 116880 

cttcacatta ctttaagttt tctcttgata actgctcaga atttattctg gctgatggga 116940 

tgactttatc actatgttag gttttggtca gcttcagaaa aaaacaaaaa ataaataaaa 117000 

caatgattaa aagaacacag atgggtatct ctttcctatt tatgtaaatt ctggatgtag 117060 

atagtccagg gctgatctgg ctacttcctg gttatcagag attggagcta tttctagctg 117120 

tcattcttag tttacatcct cataatccaa tatagctgct cgagctccag ccattatttt 117180 

gccttctggt cagtaggaag gaggaaggaa taaagaaggg tgtgcctctt tcctttaagg 117240 

agaattttag aagtctcatc acttctgctc acaaataatc ggctggaatt tggtcacgtt 117300 

gccacagcta actgggagag agtctggaaa tgcagtgttt tagtcggtat ccacctcata 117360 

atcagggctc tggtagaaag agaggagagt ggatgctagg aagcaattgg aaggctctgc 117420 

catagtctga gaatggttcc ttattttatg tacccatatt gcatgacttt taaaacttcc 117480 

tatgggttat tttatgggaa agaatttatc aaggttttgc ctgaagatca cagttactat 117540 

gttattaaga ataagagaag ctgaatgata agtaatttgc tgtattactt catatttaaa 117600 

attaaacaac tgagttttta aacactttta tgtaagatcc agattccaaa tggtcatatt 117660 

gtgactaatg gggctttagt catttttatt ttgatactcc tgtcactgag agaaatgaga 117720 

atgcattgtg aatttagacg cttcataacc acaaactaca tacaatttac actacgtaat 117780 

gagagctgtt taacaataaa acatttttat tggtgaggag tcaaagtttt cttttaatgc 117840 

ctagcacagt gtcttacaca tgaaagatat gtaatcaatg agtgctaaat tgaattgacc 117900 

ttcactagtc agttggattt atttatcgga tgtataaaag acccttgaca gcttctgcta 117960 

gtatccaatc attattctta tggcagtgtc acactagctg ggatttaatt tgattatatt 118020 

gggtggttgt ggttatgcct atgcatagct gggaccacag ggaacaaatc acttctcagc 118080 

tgtgttaagt gttttgcccc tgacagtgac cacacctgca gcttcaggga ctaggaaatc 118140 

ctccagaaca ctgaagtgca tagagatcaa tcaaatcagc tcttacttgg agaataagaa 118200 

tcgatttatc atggaactac ttagtgcaat taccatattt attatagtct tttatttaat 118260 

ccttctcaat tactgatgtg gtaatatact agaagagtgc atttaatatt ttctttttat 118320 

ctgagctata tttcttgtaa tttaccttgt aaaaaactgt agataaaatt gcaatgagac 118380 

ccttgattga ctcctattac tgattataca acaaaacata acttatacgt tttgtcagac 118440 

ttaatttgtc tttagacata tattcttaac ttgtttggaa ttagaatggc tgttcttatt 118500 

tgacattgtt tccatttcct tcctggtcac ctttataata catcaaactg gaaaagaaaa 118560 

ggctcacatt cacagattta taaaggggag aaccataacc atatttgttt agggccattg 118620 

atatctgttt ggctcttaga gtctctgttt ttgctaatgg ccagggtgaa aattatacag 118680 

tgtacaacta ggctgtaata caattatagt aaatactaat tgtaaaatta atacaatttt 118740 

aggtgcttaa agatatctgc ttaaaatttt tctagaaaga acaaaactct tacagatgtt 118800 

tggtctctgc tggctggagc aggagctagg aggtagaaga gtaggagatg ggttcttgat 118860 

cttgcggttg aagatatttt atcaatccat tattttctca ttttgggtta attcagtctc 118920 

tttgaggcaa atgttgtctt tcatggtttc tcccagcacg ccctttcctt agccaagatg 118980 

gcatctgtgt gaaggagaaa gctcacatac ccttgtgata atgcaggtaa ttgaagggag 119040 

gcagcttgtc aaaagcaggt cctgatcctg ccctttgggt cctccctgaa atccccagaa 119100 

tcaattgttg tcttgcctgg ttgctagaca gccactggca tccaccattg atttcagtgc 119160 

tggtgaaatc tgggaacagt ttcctcaaca tgttctagcc ttgtggtcct gcttccttga 119220 

ccccactgtc atctcagtga cacagaagac ccttgaggca cagccacttc cttcctccag 119280 

tccattgcct taggctcgtc ccctcatagg aactgctgtc tctgccatgg cgttacagga 119340 

aaggggtccc aatccagatc ccaaaagaca gttcttggat ctcaggcaag aaagacttca 119400 

gggtgagtct acagagtaaa gtgaaagcaa gtttattaag aaagtaaagg aataaaaaat 119460 

ggctaatcca tagaaaaagc agccccgaga gtcgattgtg gcccattttt atggttatct 119520 

cttgatgata tgctaaacaa agggctgagt attcatgcct ccccttttta gaccatatag 119580 

ggtaacttcc tgttgttgcc gtggcatttg taaactgtca tggtgctggt gggagtgtag 119640 

cagtgaggat gacctgagat cactcttgtc gccatcttgg ttttggtggg ttttggccag 119700 

cttctttact gtaagctgtt ttaacagcaa gatctttatg acctgtgtcc tgcactgatc 119760 

tcctatctca tcctgtgact tagaatgcct aaccatctgg gaatgcagcc cagtagattt 119820 

cagagttgct ctggttcaaa tgcctctgac aatgtcatct tagccctaat catagctgtg 119880 

acagactgcc actgctacta cttgagaccg tcactactgt tactgcctga gaccgtcatt 119940 

aaaagactga acaaagtgac gaacatagaa atgaaaactt aagacaaaag taactatttt 120000 

aaggaagggt ccaggggaag aagagagctc cctgcttcta gcgagcaaag gcagcccttt 120060 

gtatttattg ggtagaaaga gcagggagga ggaggtaacg actggtcagc tgcttaattg 120120 

atcacaggtt cacattatta ctaacaggct tcagatttgc ctaatcacaa gaaacacttg 120180 

tgcctggatt gtgactgccc tcctgtagtc cttctgggtg gcatacacag tttgtcagtt 120240 

cgccaacatt ctgcatttat gagaaacagt ttgctgttta ctcatatagc ctccagtggt 120300 

acactgagtt gatcatgact cttactcttt tggcctccaa caatagcaac tccatggcag 120360 

tctctatggt gttcagcttt ccactgcctt ccataagccc cagggagact tcagggaggc 120420 

tggaggagag tcagggaatc ataattggct ttctccttca tgtccacaca cgcatgcggt 120480 

gacacctcat gagcctgtgt actaaagagc ttgtgaccat ttcttcattc tctgtgtgtt 120540 

tctgttcttt ctcccgcttc tggattttga ctctgaggcc atcgtaatgg agaagtaagg 120600 

atgttatctc ctactcctct ttctatgctg tctcctcttc tagcactaga aggattttgt 120660 

cggcaaaggc ccttccttgc aaaggtttcc tcctgctgct gaagttggca ttagctctcc 120720 

catttcccta gggctgtcgt gatggaaggg tttccatgag agtggggagg ggatggaaga 120780 

caatattatc accaattcaa gaaaatgtat ttggaagttt ttgaagattt agagtacatt 120840 

tttgttgttt cactaaaata tctctttaat ttttctaaat tgtgtaactt tattcttaac 120900 

tgtttttgga aaatacatct ttttcttatt tttttccttt aaattatcaa ctaagatgtg 120960 

agttcttggg ctttgcttat tgacttaaaa ttttttttta attttatttc tagagacagg 121020 

gtctcactgt gttgttcagg ctggagtgca gtggtacaat catagttcac tgcatcttct 121080 

aactcctggg cacaagggat cctctcatcc tcccacctca gcctcctgag tagctgggac 121140 

tataggctca caccagcaca cctgactaat ttaaaacttt cttttttggt agggacagat 121200 

cttgctgtgt tgcccaggct ggtctcaaat tcctggcctc aagtgatcct cccaccttgg 121260 

ccttgcagag ttacccttat tgttttatta gtagagcaat tttgaatagt tagaataatt 121320 

ttgttaattt aatgaatttt tttttttttt ttgaggcaga gtctcagtct actgcccagg 121380 

ctggagtgca gtggtatgat cttggctcac tgcaatctcc atctctctgg ttcaagcgat 121440 

tcttgtgcct cagccttcca agtagctggg attacaggtg tgtgccacca cacttgggta 121500 

atttttgtat ttttagtaga gacagggttt caccacgttg gtcaggctgg tctcaaaccc 121560 

ctgacctcag gtaatccaca catattggcc tccaaaggtg ctgggattac aggcatgagc 121620 

caccacaccc agccttaatg aactttaata atgttactat ttgtgtcgat tagcaacata 121680 

gcagatagtc acaacagcta aaccatacag aacattttct atactcaacc caaaggttgt 121740 

gtgtaccgtt cgtcttccgg ccagttcagg ctttccatgg caataaatcc ctggggacta 121800 

ggacctttca ggaagcagcc tctggttaaa gtctacttcc agggatatgg ctgtttcctc 121860 

atggttctga gagccaggag gctctacgtg tggaacaaac tgaccaaatt caatgaatca 121920 

ggaagtgaca aagatagttc agggaaggat tagtctctag attactgtat ttttgatacc 121980 

aataattgtt cttccttttg cttattttac ctttatagag ctgggagcac ataaaagata 122040 

aggcaggatg tgaatttgac caggtgtgcg tggttatcac caggcttaaa gaaaaaaata 122100 

tctccctttg acatataaag agcttctaaa tcagacagca aatcataact agtgtcactc 122160 

agtgtcaggc attgtgctgg gttctttaga gttacagaac atttatgata cagtctgtga 122220 

tttcaaagag cttgagtctt gttgaaaata ttatccattc attcgctaaa tatttaatga 122280 

gttcatacta taggagaggc actgtgatat gtgggcatag agcagaaaca aggtagattt 122340 

gaaccctgcc tcaatggaac tgataatcaa gtggtactga tattcaataa ctgactctgg 122400 

atgtttccaa atatccccaa ttctagccat agaaagttcc gttgtttttt ttttcagatt 122460 

aattaaaaaa ctcaagcaca tcctgggtga cttcatgaaa tgcagtccct ctcgagcact 122520 

ctgatgattc cagggagtca ttaggttctg gctgtcacct gacaggtctc tctctgggct 122580 

atggttttgc atttccacag ttcccttcag gctctctctg atctgtttct ctaggtggct 122640 

gtcctctctc tactgtgctt ctaatcagtc tggggagcct ccttttttta ttcttcaaag 122700 

cttcaccctc ataaagctcc ttattcactt agttgtttag cctcttttta gaaatttgtg 122760 

atttacctta tttttaattg acaaataatc actgtatatg ttctgtattt atggggtatg 122820 

ttgtgatgtg ttgatatatg tttacactgt gcaatgatta aattaagcca attaacaact 122880 

ctatcaccta tttatgagtc tttaccgaga acttcaactg agccaagggt gaatgaggaa 122940 

ggagaaaatg aaaaaacagt gaaatttaaa aagcagagat aactactcct aatgtttatt 123000 

gactgctccc ttgcatagat gtccacaaat ggacagtaaa ttttttagct ctgcaaatat 123060 

ggagtgggag acagagagga atgatggtgg aaacatgaca ggagacttgt ggcccatgaa 123120 

ataaatgttt gtctttattt taaggctaat agaaaaataa gaagcaattt tacaaaacat 123180 

gtatgttggg atgtctgagt atgtatgtgt gtaatgagca ggctctcttt agaaacaatt 123240 

gtgtggagaa tggcttagct accaatatta ggtggcatac actagatgct ggatgagcag 123300 

gagcagtgtc atatactgat cgatgttttc cctcccaaat ctgacagtag atctgtcaga 123360 

catcaggaat ttcttcccaa cagcctgggg ggtggaatac tgcagtccaa tcacaaatga 123420 

tattcccaaa gtgagaggca gcaggtgtaa gactgagctt atttatatag caggtctgtg 123480 

tgattacaca cagtattgta aaatatacct ggtagaataa tttcatggag aaaaagtccc 123540 

tcttaacctg gtatcagaag tagatgtaca gggaagtgaa tgaagttgaa gtttcaaagt 123600 

ctctcaattt cacaggcctt ttcctaggca cctagcttta tattcatttt attaaagaaa 123660 

gttttgtact cttcagatgc cacaaaacct ggatccacct ctgtccagta tagtccccag 123720 

gtattcatgg agaaagtgga atttgaactt gcccttgaaa gaaaattagt ctgtgcatat 123780 

gtcaaaaaga atgggagccc attctgagtg aggataactg tgggggcagc atggagggtg 123840 

cactggaggg ccatgagtca attgattgat gggtaccagg gatcactaaa gcaagtgttg 123900 

gatacccaaa ctcatcatct aaggtgtttg cattggttgg ttatttacgt tccttggacc 123960 

ataggaaata gatcaaaact tatgttagct taagcaagag gaggtttatt gtaatagaaa 124020 

cagcattatg ggccatgcac agtggctcat gcctgtaatc ccaacacttt gggaggttga 124080 

ggtgggagga tcacttgagc tcaggagtta gagaccagcc taaacaacat agtgagatcc 124140 

tatctctaca aaaaataaaa acattagcag ggtgtggtga tgcatgcctg tagtcccagc 124200 

tacttggaag gctgaggtgg gaggcttgag cccaggatgt caggttgtaa tgagctgtga 124260 

ttgtgccact gcgctccagc ctaggtgaca gagacagact ctgtctgaaa gaaaagaaag 124320 

aaggaaggaa ggaaggaagg aaggaaagaa agaaagaaag aaagaaagaa agaaagaaag 124380 

aaagaaagaa agaaagaaag aaagaaagaa agaaagaaga aaggaaggaa ggaaggaagg 124440 

aaggaagaga gagagagaaa agaaaaggaa aaagaaaaga aaaaaaagga gaaagaaaaa 124500 

gaaacaatag tatggcttgg agtgtgtagg ctggagttgg agagtagatt aagatcctga 124560 

aaatcaacaa ctggagtaaa tggaatctct tgcctattgt ccaccattat tggacccagt 124620 

tattttctac ttgtcataat tttgtttcta ttaacagttg cctattcttt ctctgtattg 124680 

tcaatataat tccttagctt aatcatcttc ttcctcatgg ctctgttcct gatactaatc 124740 

ttccttattt tcttgacatt ctcaaaaaag gaagtctctt ataaggtcac tgttccttga 124800 

ctggcaaagt catagatcag tggctaacct attgcttgag cttgcacacc ttgtccaatc 124860 

aggtatgcct aaaatgtaca gaatctttgc acaaaatagg cgacctgtag ttgccccttc 124920 

agaagttgtg ggccagggaa tttcccttac aagaacctct aggtgaggct agcataataa 124980 

atggcctgtt tgttatggct gaaataggaa tagctaatat tttctgagtg cttactttgt 125040 

gtcattgcat cagattctgt tctaagtgtt ttatatacat taaccccttt tttaaaaatt 125100 

taagagtcag ggtcttgatc tgtcacccag gctggagtgc attggtgcca tcatggctca 125160 

gattcctggg atccctcaaa ttcctaggct ccaggaatcc tcctgcctag gtctcccaaa 125220 

gcactgggat tacagacata atgggcagcc tgcattaatc ctttaattcc accaacaatc 125280 

ttataggggt agttacaacc tttattccca ttccaccaag aaggaaactg agggccagca 125340 

agttgcagta acttgcccaa ggtcacgcag ctaataactg gtggaaccag gattccagct 125400 

gggcaatatt tctagagttt acccttcttc ctgcctaagg tttttggcta tcaatccccc 125460 

caaactatgt cgaagtcccc acttatttga aagtggtaac agttctattt ctccaattcc 125520 

catccacccc tatccaatct tagtccaaaa gtgaaacatc cacaataact agctgtattt 125580 

gctctctgcc ttccactctt gctcattcag tcctgtcttt gttcaagact tccccgcctc 125640 

ccttccagtt cttcttttca tgctctgcac ttccttatga aacctcaact cccctcaatt 125700 

actttaatat ttcccctttc tgtgaattct taaggcttct acaatctgtg ctattgtgaa 125760 

gagaccagta taactgcatt taaggtctat tatcttaaga atatattttg atgttgtaga 125820 

aagagaaaaa cacagaaccc ccttaaaaga tgaagattca agaagcagtg ctagaagtta 125880 

caaagcctag taactgtata atctctttag atagtgaggc tgtaaaaact ccaaaagatg 125940 

aaattaaatt gaggagacag ttgtaaggca ttggagtctt taatatagtt tgagttgatc 126000 

agagtctcac gaagtggtgt gagaacgctc aatggaagga cggtccccag cctgcccact 126060 

ttgtttctcc aggcagtttg aattctgaga ggaaagataa gaaaggaagg aaactttgga 126120 

aagtaagaag gggaaaccgt ttatttttgt tgttagtgtg atatagcagg ccccggacta 126180 

gaaatgatgg ctcacaccca aaagaccagc aagtaaataa tgacagtaga taacgtgcag 126240 

ctgtacccat ttcctcagaa ttttgctgaa gtgacaaatc tgtctgtatt ctctgtacag 126300 

aataacaatt aattttttta tgaaagcaat ctttttacag ctaaataatg aattaggcac 126360 

cagaagcctg gtttctagtt ctggttctag gtctagattt gagcaagtca acttcactca 126420 

gctttttttt ttttcaccta taaaatagaa ataatatcta ctcacttata gacattgcat 126480 

ataaaaaatg tagaagaaat cattcattca aacaccacat agtaattaaa ccacgttgtg 126540 

gctgactctg gtttactcac tgagggtcca tcaacaaaca gaaacgtgaa aatctctgct 126600 

cttgtggggc tcactgagta gtataattgg ctagctcaca tgttttagtc ttttaaccct 126660 

gctcagttat ctatactttc atttctttaa gaaacaagca tttgatgaat aaggtatgtt 126720 

ctagggtatt tatgcgtgga ttaaatctac aaatctatta ttgggcctag tgatagagca 126780 

gaaagagaaa gctagattcc agataggact ttgctgcaag ctagctttgt gactgtaaaa 126840 

gaaagtggct tcatatcctc atctgtaaat aaaagagttg gattacatca tctccaaggc 126900 

tccttttagc tttaaaatgt gcagttttct ttatgcccac agggatcact accctcttgg 126960 

tggcagctgg catggtgcct aagaagaact tgccagtgct cagaatatac cctgcaaatt 127020 

ctaacaaagt agatgatggt gaatatcacc atcctatgct ctggagagtg actatgtgcc 127080 

attttctact atttcttgtt atttcaattg cttcccaact agagcacaca ctcctgcaag 127140 

gcaggaatca ataagtgcat tatacatatt attatccgga tcaggaaaga ctcctctgat 127200 

atcagaagcc tggatttgtg tttctaaaat tatctatatt ttcccccttg agtaggtcaa 127260 

atgctgctcc tattacctta ttaatttttt gttttgctta ttaatttgac caattaagac 127320 

tattttatgt cacgaacaat ataaaattta gttctaccct tattagaata atgtgttcat 127380 

tccagcttaa tgaagtttca ttatacttgc ataaaaagtg gggggaggtt tgtaaatact 127440 

agaacttaat atgcaataca ggtatatcta gcctgagtac tacaatcaaa gatgagagca 127500 

tataccaaaa gtttctaaga gactagtttt attagcacag gaatgaaaac caattataga 127560 

atttggaggg agcgaggcag tagagtgtgg ttaggacatg tgttttggaa ctagactgct 127620 

ggcatttgaa ttcaaactct gccactcatc tggaggtgac cttaggcaag ttactttacc 127680 

tatctatgct tcagtttctg catatctcaa gtgaagatga taagagtacc gattacaaat 127740 

aattaaatga attattattt gtaaagtgtt tgaacagttt ctgacaaagg gagaggacct 127800 

tctaattctg gtcagttgtt taggagggag ctaaaaggag aggaattagg agcacctgag 127860 

actgcatgtc acttaaagaa gctggtgtta aagggaggca aaacattcga ctgcacttgg 127920 

aggaaggagt agagacaaac agtcaagcac aggtgtttgt gtgtattggt ttcccaagac 127980 

aagggaaact tccacatatc tgaaagtgga tggaaaggag ccggtggtca ggaagttgga 128040 

agagggaggg gatagctatg ggagcgggat gacctgtaac aaggactcaa gtaatcagag 128100 

gtgaagagag ggaattctag gatggttttc tctttttcct tcaaaatcta gctagattta 128160 

tgccaagtta cacttctggc cttgaaattc tgaaggtgac agcacagacc atcatagtcc 128220 

tcagttattc aggatcaagc agtggatggg gataaattag tgagctagtg taggtgagca 128280 

gaaagaacta ttaatgacat gatggaaagt agctataacc ctgtggtaca gctgggtcat 128340 

tctggaagga atctcgtaga caaactagca tagtgttcag cccacagagg cagcatggct 128400 

ctgtgaatac aggcatcagg catcctcagc taaaccataa atggcacagg atccacaaat 128460 

gagccatagc agaaggccaa acaaatgagc tatgtttctg gagtctccat ttggtgtctg 128520 

tgacgtgccc atttacacat caatcttctt tcagaattgc cataggaaaa taatttggcc 128580 

caagagttaa attcaaattg gaagatcaac accgaccctc cctccaaata cgcagttaaa 128640 

tagcctgaac caccttaact gaattatttt aaaatatcct gtaacacagc ttagtaaata 128700 

aagctgtcta aattgaaatc tttggggtct cacatccaaa gggaggataa agtttgctgg 128760 

cagattggat atcttatata cttggcaatt tgggaagaac acagcagagc tgcaagttta 128820 

gttgaaacaa gaacaagatt tatttcagac gggaagatcc taggcagcat aaaggaaaat 128880 

ctttatggct gcaagagctg atatgtctaa gagaggctcg ttagtacctg cttatcctta 128940 

tactttcagg acaggtcata tttgatgtga atgaagatca gtgtattaaa gggtttaagc 129000 

atgaaatgaa attaaaggca aaggagcttg gcatcacctg acatatggta gtctttatct 129060 

tttagaaatg ggaaactttc aaagatattt atgatttgcc aagatttgcc ttggaaacaa 129120 

tatgcaggat atgttaaaga gaaggaaaac tttggtcaga aacagtagta acaaggctat 129180 

tagtagatca aatcatatat aatccccaat atacagcaat tttttaaaat ggaatttatt 129240 

ttttggagca gtccatagca gaattgagaa gtgcagagat ttttcacaga ctcccctggc 129300 

cccacatatg catagcctcc tccattatca atgtccccta ccagagtggt atgtttattg 129360 

caattgatga atctacaagg acaccgcatt attacccaaa gtccatagtt tacattaggg 129420 

ttcactcttg ctgttgtaca ttccatgggt ttggaaaaat gtataatgac gcgtccacta 129480 

ttatggaatc atagattagt ttcacagccc taaaaatcct ctgtgctcca cagacagtgc 129540 

cactagggaa acatatgctg cagaactctt ggctcttgac aaactacctt gcagtgcctc 129600 

ttactttagg tttttttttt ttaatctcct gctatttgac attgtacagg tatgtgatat 129660 

cgaaattcct acagctgtag tctgcttcta aagtttagcc aacaaataat gcaagcccaa 129720 

gggcatttcc ttagttaaag caggcctcta aataagaacc aagcagcata atagcaggaa 129780 

gaggaaccta gttgtcagct aaggtaagaa cttatcctaa ccagatcgtt ctttagcaga 129840 

tggagaatct tctcacatag gagtacaaag ggggctttga aagtcttgca gacaaaaaat 129900 

ttaaaaagac cccaaaaacc tgttctcctt tctcctccaa gtctgaccac tcttccagaa 129960 

ccataaaatt tctgtgcaaa ttgccactaa actttttctg tttgctgtgg aataggtatt 130020 

ggtcaaagtg taatttttgc tgcaaagaaa acatggcatt ttatgattct tcacacagca 130080 

ctgcctacct aaaacagaaa tcatccattt gcttaacaca gttaaagatt ggaaaactat 130140 

atgtctgtct ggactgcttg tataatgcca tgccacttaa aatggccgtg ctgtttaaga 130200 

taatcttaat taaattttta aggaaaaaaa aactttagaa agccaattaa aaaagactga 130260 

agaaacactg gattttattt ctttctcctt tctcttgtaa caaattttta tgaggaattc 130320 

attttattgt gtctttttct tataagacaa ttactgagaa atttataaaa aaaaggaatc 130380 

gtttttctgc tgtgacatcc aatgaattta ggagatgtgt aatatggaga atactgttga 130440 

gggatgggcc tcaggactgg ctgtgcagca ttgtccactc aggccacaaa tgcttatcca 130500 

ctatgatttc tgtgccaggc accgtggtag ctgctggaga ctcagtggta agcaaaacca 130560 

ggcacagttc ctgctcttgt gaagcttata gcttaggtac aatgacacat caataaataa 130620 

tcacacacat aactatacgt ttcatatgcc atgagttcct gaaagaaaaa atagtagatg 130680 

tcatatagtg aggcaccagt cctagtgaac aggatgttct ccaagaaagt gattctccaa 130740 

gttgagatct atcagatgag tagaagttag ccaggtgatg aagaaatgga agcatactgc 130800 

aggcagaaga aagtgcaagt acaaaggccc tgaggtatga agaaggatga cactgttcat 130860 

aatgttcgaa gatggctagt gtagcctgag catttaagat caaaaaggca aaaagtttga 130920 

aaagagtttg aaattgcatc ccgaggccag ataaaacagc ctttgatgtc atgttaggaa 130980 

ttctattctt tatcccagag caatgggaaa tcacgaaaaa taatcagctg gagggtggtt 131040 

gaattagatt tcccttcacc aatcacttga ggtcaatgag ttcttattca gcctttaaca 131100 

agtgctgtga taacttcccc agtcatatca gacatggtct ctgcctgcaa gtcgtatttg 131160 

atgcgtaagt gtaggaggaa ataagtgtga gtcaaagcat ggaagtagaa atgagatggt 131220 

cctaggaagg taatatctaa aacatccata ttgatcatag ccaatgtgac tttgatatgc 131280 

aggttttggt tttgcttttc tttaaaaata ctcaaggaag tgtcctgtga aatcctctgt 131340 

ctgttcacag atcaggtacc acacaaacaa ctatgcatcc agctccacct ccttaccctg 131400 

ccagtgttcc tcaaccttga tgtggagcga ccatttggaa aggtgagatt tagaaactgc 131460 

cgggatttat agcatagcct tcccccgtct ctctgttcta atcggagttg atgctacaaa 131520 

ggcagaccat ctctgagaat taaaatgcaa attaaacata tacatctgat taagagtgct 131580 

agattcctta gaggagttgt tgtttttaac tttacttaag tttcctccaa ccaagagttt 131640 

tttgaaactg gcttgagtct gatcttgtga ctgatcaagt ctcttgccat gaaagaatct 131700 

gtaagtcact gattttttca tagtaaggac agtttccagt agtatgttaa ggctaggcca 131760 

ctcctatttt aattaggtat cagaatccag cgtgttcgcc atatggctca tatggctagc 131820 

acactctcag tcgcattttt gattagatct attttgaata aaacatgtac ttcaatgaat 131880 

gagtactcta aaaggcagaa cttaatccca aatgtcatgt atgattggcc atatcaaatt 131940 

ttgagcttta gtttcttccc tcaagcacct ctttttagta tttctattaa tggctaattg 132000 

aatggaaagt ctgctgggaa ttatagcatt gtgtgatttt tttcttttta agaaggactg 132060 

tgaaaaggtt tattttttca gagataacac agttgactta tcaaatgagt tgaactcttc 132120 

attttagcga aaaagcatgc tcattttatt ttattctctg ggtaatgtca ggtacagtaa 132180 

cccctctgct cggtacaagt tgttataact gatatgaaca ttcaagcagc tcaatttctt 132240 

tagacattta tcctcatggt tgagggaact gagagaattt ttcctgtttt tcagaggaag 132300 

agatgaatgt gttttttcaa tagagatata tagtgtgcca cttacaggat aagaacaagc 132360 

tggttgattc tggaaaacag cttaaaaatc atgaggccaa tacaattttt actcaactca 132420 

catttataat cctatatcct tccccacatc tatctgtcta cgtatctatc atctatctat 132480 

ctatctatct atctatctat ctatctatct atctatcatc tatctatcta tctatcatct 132540 

atctatatct atgtatctat ctgtctatct atctatgtct ataacacaca cacacacaca 132600 

cacacacaca cacacacgtg cacactgggt actgttttgc tgttaataca gatttcccta 132660 

gaaaaccaat gaagggaaac gaagagagat aacttgtttc catctctttt ttggtaggtt 132720 

cactctaact ccatttttaa ttttttaaag taaatcttat tatacttttg ctcagttaca 132780 

aaaataagcc ctgttctcta tggaaacttt ggaaaatgat gaaaattaga aagaaaaata 132840 

gcttactaaa ctttagtctc accagtcagt aaaaattcag tatcatgtta gtgtatgttt 132900 

ttctattctt tttttcctgc agttttttaa ttttgtttta catacttatg ttaatattat 132960 

gatatacatt ttttaatctt gttctcattt tatttagcat aaaataagca tttctcagac 133020 

catttgcaaa ttctttgtga agccatttta atatttatgt aataggttat ctaaataata 133080 

cactgtagct tacttaacca tatggtcaat tttgtggtca aatttgccac attgatgaaa 133140 

atattactgt atcattaccc aagtactgaa aggcagaggt ttgaaaaaac tgtttatata 133200 

tatatatatt ttaccataag gagaatttat ggaataagta atgtgtaata tttaatgttc 133260 

tttaaagata catgtagaca gactgtttgc gaaaataatt agatttaaaa tttcatcaac 133320 

cgtgtgtgaa aaaatttgct ttatactaat tggcactgtg tactatctta aaaaaataaa 133380 

cagaatactt taattaatga attaattatg tttttttgag atggagtctc gctctgtcaa 133440 

caggctggag tgcagtggca tgatctcggc tcactgcaac ctccacctcc cagattcaag 133500 

cgattctcct gcctcagcct cccaagtagc tgggactaca ggtgcacacc accacaccca 133560 

gctaattttt gtattagtag agatggggtt tcaccatgtt gaccaggatg gtcttgatct 133620 

cttgacctca tgatccactc gcctcggcct cccaaaatgc tgggattaca ggcatgaacc 133680 

accgcgtctg gcctactttg atgttttgat aggaaaatat tctatttcct ggctatttca 133740 

gcttctattc ttccttattt ctttttagac tagagttata tactaattga aacttgtttt 133800 

tacaacaaga ttatttgacc atttattgtg cctacaattg cttttttaaa tctaaaacac 133860 

atgtaattac ttcaaaagag aatgttttaa acgtttaaag caaacaaatt tattacttat 133920 

attttactcc tcacaccata cacaaaattt aaaaaaaata atccccatcc atgcttattg 133980 

catctttctc tctctattct aacagataat gaaagaacgg agttggacat tttattgcaa 134040 

ttcctgcttc cctgaatttg catatttctt cccacctgag aaggataatt atatatttta 134100 

atttggatta tttcttcatt tttatctttt tattttaatg attgttttgt cagtaatacc 134160 

catggagatc aactttatta ttataatcca tgcctctgaa tattagattg gtttcttgga 134220 

tgggattttg aatatgcatt taagaagttg ggaagaattt cacagatgat gattggagga 134280 

aaagtgatga aaagaaagac ctgtgttcca ggagttttct ccaacttcaa acctttacgt 134340 

gaatcttaac caaagtggac atctttacat ttcatgatag cttgcttttg caatatgagt 134400 

ttgaaaaatc agtataagct tatgatggtg aaaagtcaac atattgagag tgataattca 134460 

attaatagga tatgaactta acgacatata aaagcaaatg agggcaggag ggaatcgtga 134520 

caaaaaatat ttgtgcccaa ttatgattaa tgttttagag atgttgtgtc cctgtgggct 134580 

tagcatggaa ctaaaagttc ctaagtctca attctagtta tgtgtcattt agtaactcag 134640 

gaatctgctt aattgttatt tctaagcttt tgatgacaaa ggagtgatgc agctaagggc 134700 

atccttggag tgtcataaaa aacaaatttg aggttgaatg attagctgcg cagttagagt 134760 

gataaaaaaa tccaggtagg ccttctgatt caccatgacc aagtcaggat ttcttaatat 134820 

ttcttttctg gcagcatata caaaggcaaa attaataaat aacagttgtt gaataacaaa 134880 

ctttattacg tttttataaa ataaaagaat ctattttgtc tgtattaaaa taaaaaactt 134940 

tgtggacttc taaaagatat acttgagtca tctaatagtt ttcaacggat atgccgttac 135000 

ctgcttttaa attcaatcag cttttcttct tcttgtcctt ttttttctct tcctcccttt 135060 

cttctgtccc ctcatttgct taattcacca catatttact gagtgtctcc tctttaggta 135120 

ccatgctaaa ggccatgctg tcacctatag gacatcttgg gaagcgatga aaatatggta 135180 

tcagaagttt tgctgtagga tcatatgctg tgactacata tcgtttctgc caactataat 135240 

gactcaatag tagagtcctt cttaaatagc agaagcagtt gtgaattagc tataaactat 135300 

aactattttc ttccaaatct atatttaaaa tggtcttaac tagcacaaag ctgatgctgt 135360 

acacaatccc tttacttagg tttaaattca gtgaatttta ttgagtacat agtatttgcc 135420 

aacatcagaa gaatgtccat tcttctgtta cttctatctg ttcctcattc acctgtgtga 135480 

ctagctgtca tctattcact attttatttt tacaaaagat ggtacagttt ataaagggct 135540 

taaccgattt ttcataccta acataagtaa gaattcaaat tcaggttcaa gtttttaaaa 135600 

ttccaggtgt actgttcctt cttacagcac aatgggatga aagatttgct gcagtgatat 135660 

tctgtttaca agacaaagtg atgtggtaac agaagcatga gtttggaatc aaacttggat 135720 

ttaaatctgg ctgtgccact cacaagctct gtgactctga gaaagttaat tgcatctcaa 135780 

taaattaatc tataaattga agataatagt acttacctgt agggtaattg taataacgta 135840 

cataaaatga gtgttacacg atagatcctc agaaagtatt tactatgatt gattctttac 135900 

ccagacttat ttctacctat ttaatgtgaa tctcaatttc aactataaac cggcttcttg 135960 

actctgtggg tttaaatgtc atgaacggaa tcaaccccaa ccatcctttg gatgctattc 136020 

ttgtttttaa gacctcacga taatttttgt ccatgcaaaa cctacccacc tcccacatgt 136080 

tcagatctca ccttgtcctt aggccttgaa tactttaagt atttttgttt tttccttacc 136140 

tctgtctgca actttgaagt tacatagtac tcattttgac tattgtattg tactattcct 136200 

tgaatatttt cattgtatat gtctcttccc atgtgacaaa actgtaattc atggtggaga 136260 

ggactcgttt cttaattttt ttccacaggt ctcttggcac tagtgtagtg tttgacacct 136320 

agaaagatgt tactaattaa gtaaattatc agcgaaggta acatttatgt acaagattaa 136380 

cataagtgaa catgatagct ttttgttttt atgttgttgt tcatgttagt ggttgttgtc 136440 

atttcacgtt aaactttcct tgtttaaaaa tgtctacatc cagggagaat aatcacaaga 136500 

agtgcttttt gtttgtttat ttgtttgttt ttaagacaga gtctcactct gttgcccagg 136560 

ctggagtgca atggtgcgat ctcgggtcac tgcaactttg gcctccccag ttcaagcaat 136620 

tctcctgctt cagcgtcctg agtagctggg attacaggca cccaccacca ctcccagcta 136680 

atttttgtac ttttagtaga gacggagttt caccatgttg gccaggctgg tcttgaactc 136740 

ctaaccttaa gtgatccact cgcctcaacc ccccaaagtg ctgggattac aggtgtgagc 136800 

caccatgctc agcccacatg aagttttaca tagcatgttt attaaaggtt tttttgttaa 136860 

agtaataagt aacaaaataa ttagaaaagt tagaaaaata atgactattt ggcaaagata 136920 

cttctcatac aatgagaaat atctttgtcc aattagttta aaatctgatg tagagaaact 136980 

gtatatctat atatacatat cagtatatat atatatgata cttaaaaaac tactttagtt 137040 

tttagagtag ttttagtttc acagaaaaat tgagcaggta cagagaacat ttttgtttac 137100 

aatctagaca aatgtatcca ttgtgtacaa attcattgaa aataatgtta tattatgtta 137160 

tatgtgtact caaatactct gggttgtaat tcagcaaaac actggttttt aacaagtagc 137220 

ttcatcttca tttttgttat tttcaataaa cacaaattct tgtcattatg caacaaggtt 137280 

ataataaaga tagaactaac cctcaaaata aagtaagatc cttaagaact ttgccaaaaa 137340 

aaagttactt gtgaagaact gatgtttgat ctacagtttt attttaatta tagtaactac 137400 

tgtaaagttc tgtgggatac atatgtgaaa caaacatata acattaatat gctttaagtg 137460 

ggctgtatgg acatgagtcc tgactataca tataatatat tccacgtact tttaaactta 137520 

cagcttttgc attggaagaa atgaactgct gcctactcca gcccccattg tattgcagca 137580 

ttagtgcttt cattcagcat cagtgcaacc caatgtaaaa gaaaataaac aaacaaataa 137640 

acaaaaaact cagctgtgct gttcccaaga gaggttggac cagggtaatg tgaacaagca 137700 

tgccaagcca tgccgagatc tgttagccag ggatacgtaa gagaacagag aatattgtgt 137760 

ttagaagctt tggcttccgt cagaaggtat atttatctaa gttctcccaa ggagggaaga 137820 

gaaaagtaga gtcattatct tttacataat aaaatatatc cacagaatat atgaaaattc 137880 

agacagagtt gacttgggtc tgtgttttta gtatctaaaa gaacaatttt caaaaattaa 137940 

ataaataatg aaataaaagc tataaggaaa tcagataaac taagagaaaa agtttttcaa 138000 

catcctttgt aattggaagc acatttcaaa gaaaactgtt cttaagataa ttgtcattat 138060 

gcaggtatct taaggatctg tataaaatat acgcttatca ttatattttt agttatgact 138120 

acagaagtgt ttaattgcca tactaaaaat atctgtcctc atatttttca ttaatccagg 138180 

cttttactga ctattttatt aatacaaaat atttctaggc tcatcctaga ttttcgacag 138240 

ctttattttc attatctgaa ttttttttac tttaaggtaa tttgtacaag atatattttt 138300 

aaaaacttct gtatttttat ttaaatctca accacattgt aagctattgt gggcaggact 138360 

taaagcacct acagagaacc tatagagcct agcagagtca gtactaagca catagaaatt 138420 

gctcaataaa aatgtgatga atagtctcgg tggaccagac tataatataa atgaatgatg 138480 

cctaagacaa gtaggtgata tcacactgtg agtaatggtg gcatttagtt ggcagttgat 138540 

tctctattta catttctttt ttgatattat gccattttgg cagtcttatt taagtagtac 138600 

aaggaagtct ttccttagac ttcttgaaga aaacatctgt atttttttta acatggcatg 138660 

acatgactgc tgttaagaaa aaatgtaaat tagttcaatc attgtggaag acagtataga 138720 

gattcctcaa ggatctagaa ccagaaatac catttgaccc agtaatccta ttactgggta 138780 

tataccccca aaatagaaat cattctacta taaagacaca tgaacatgta tgtttattgc 138840 

agcactattt aaaatagcaa agacatggaa ccaacacaaa tgcccatcag tgatagactg 138900 

gataaagaaa atgtggttca tatacaccat ggaatactat gcagtcataa aagggaatga 138960 

gatcatgtcc tttgcaggga catgaatgaa gctggaagcc accatcctca gcaaactaac 139020 

acaggaacag aaaaccaaac accacatgtt ctcattcata agtgggagct gaacattgag 139080 

aacacatgga cacagagaag gaaacaacac acaccagggc ctgttggggg gtcgggggtg 139140 

aggggaggga acttagagga tgggtcaata ggtgcagcaa accaccatag cacatgtaca 139200 

cttatgtaac aaacctgcac gttttgtgca tgcatcctgt tttttttaga ataaagaaaa 139260 

aatgtaaaca atgaaaaact agataaatat aagcctgcat attaaataac ttcttttttt 139320 

atattcattt tttaaaattt tttatttcta taggttttgg gggaacaagt gttatttggt 139380 

tacatgagta agttctttag tggtgatttg tgagattttg gtgaacccat cacctgagca 139440 

gtatacactg aaataacttg ttttagccag ctatctaatt tcttaccttg acagaagagc 139500 

tgaattttaa ctttacacct acaggcagat gaaggtattg cagaagatat atagcctgta 139560 

caataaaatg aacataattt gcacacatga gaacaggaga aaatataaat tgtattactt 139620 

ctttgagcaa agtatagtgt tctctttaca gaaataagta caccagagcc ttagtaagtg 139680 

aataatagtt ttcagtttat ttccagataa aagttggtga ttgctaatta tggctttaat 139740 

cagtttattg gtttaacata aaactcaaat gctaaatctc tttagatgca ttggaattac 139800 

ataagaaata tttgtggagc attactttga gaaagtagta aaaaataaaa ttccaagtac 139860 

atatcaaaaa cctgagaact taagtaacaa gctctgaaat cctatggtcc tggaagagca 139920 

gaagaaaata cacgctaaac cacagaacaa tgaaaaatac aggataaagc aaaagtaaag 139980 

cagagaggaa tgtaaatttg tcacaaaaca agacaaagga taatttatta agaggtgctc 140040 

cataaacact tgctgcttgt tgtggtggtg gtagggagat gctgctgctt gatggtgttg 140100 

gtaaagaata agacataggt attcaagtaa aattagctaa ctgtcatatt aagtatggag 140160 

ggaatgggga aaagatagta atatagtctt aaaaaaactt ttgaaaaagg aagaaaaata 140220 

aaggattgag ttagtctcct ttctatgtat ctaatcatcc tgtaagttac attagttcta 140280 

caagtattac tcaattctgc ccctccgtct ttgctggcat ggtctacatc taggtctcca 140340 

tcatttccca tctgcattgc ttcagtaaca ggtgtctttc ttctggtcct ggcccctcca 140400 

tccattttcc acacctgctg ccagagttat gttttgttaa taaaatgaaa atctgctttt 140460 

ttttcttttt taaacatctt taatattttc ctgtgacttt taggataaag ttaaaccaac 140520 

taaacttagt ccacagagct ttctacaacc tagttcctgc aaggctctga ttttttttac 140580 

atccacctgg atttacagca atgcctacct gctctctcac atctctgtgc ttttcatatg 140640 

ctgttctatc tacattggat actcccttct ccctttctgt atgtgactaa ccctcactca 140700 

tctttcatat ttcaacagaa gtaccacttc cttcaagaaa cctccttcct ttagaaaacg 140760 

tttttctgtg tttaatttgt tggtttattt gtccatcttc tttgctatcc aagatgggaa 140820 

ccatatttct cacttccacg tctggtgtgt ctatcacggt gtatggcata gagctggtac 140880 

aaacaaattc ttgctggaga aagaaagaac ggaaagaaga tatgcaacaa tcaactatga 140940 

aagtttgagc aaacataata attcaagata attcaagact gaaaccatcc ttttgttact 141000 

taaaaccaat agttagtcac attttctgaa taaccgcttg atatggtttg gctctgtccc 141060 

tgcccaaatc tcatcttgaa ttgtagctcc cataattccc acctgtcatg ggagggaccc 141120 

actgggaagt aattgaatca tggggcgggt ctttcctgtc tgttctcatg atagtgaata 141180 

catctcacaa gagatgatgg ttttataaag gggagttccc ctgcacatgc tgtctttcct 141240 

gctgccatgt aagacatgac tttgctcctc attcacctcc tgccatgatt gtgaggcctc 141300 

ctcagctatg tggagctgtg agtcaattga acctctttcc tttatagatt gcccgtttta 141360 

gctatgtttt tgttggcagc atggaaacag actgatacag taaattgagt gttgctataa 141420 

agggcacctg agaatgtgga aacaagtttg gaactgggtg ataggtagag gttgaaatag 141480 

tgtgcagggc tcagaagata ggaaaatgtg ggaaagtttg gaacttccta gagaattgga 141540 

gggctcagag gacagaaaga tgcgggaaag tatggaactt cctagagact tgttgaatgg 141600 

cttggagcaa aatgctgata gtgatgtgga caatgaaatc caggctgaca tggtctcaga 141660 

tggagataag gaacttgttg ggaactggaa caaaggtgac ttttgctgtg ctttagcaaa 141720 

gagactgacg gcttttagcc tctgccctag atatatgtgg aactttgaac ttgagagaga 141780 

tgctttggga tatctggtgg aagaaatttc taggtagcaa aatgttcaag aggaagtgaa 141840 

acattaaagt ttggaaaatt tgcagcctga ccatgcaata gaaaagaaaa acccattttc 141900 

tggggagaaa ttcaagcctg catcagaaat ttgcataagt aaccaggagc ccaatgtgaa 141960 

tcaccaagaa aatggaaaaa atgtctccag ggcatgttgg agaccttcct ggtagcccct 142020 

ccatcgcagg cttggaggct taggagagaa aaagtggatt cctgggtccc cctgctgtgt 142080 

gcaggccagg ggcttggcac cctgcagctg ctccagccat ggctagaggg agccaaggta 142140 

ccgttcaggc agtggcttcg gagggcgcag gccctgggcc ttggcagctt ccacacggtg 142200 

ttgggcctgc aggtacacaa aggccaggaa ttgaagtttg ggcccctctt cctggatttc 142260 

agaggatgtg tgcagatgcc tggatatcca gagattggct acagggtcag ggccctcatg 142320 

gagagcctct gctagggcag tacggagggg agatgtgagg ttggaacccc catgcagagt 142380 

ccccactgag acactgccta gtagagccat cagaggaggg ctcccatcct gcagacccca 142440 

gaatgtggat ctcccaaagg cttgtgcggt gtgcctggaa aagccttaga tactcaatgc 142500 

cagcccatga aatcagtcag gagaggggat gtaccctgca aagccagagg gacagagctg 142560 

tctcagatta tgagaaccca ccttttgcat tggcgtgacc tggatgtgag acatggagtc 142620 

aaaggagatc attttggagc tttaagcttt gactgcctca ctgaaattca taattgggtg 142680 

gggcctgcat ccccttcatt ttggccaatt gctaccatgt ggaatagctg tatttaccaa 142740 

atgcctgtac ccccattgta tctaggcagt aactaacttg gttttgattt tacaggcaag 142800 

ggacttgcct tgtctcagat gagactttgg actgcagact tttgagttaa tgctgaaatg 142860 

agttaagact ttgggggagt gttgggaagg catgattggt tttgaaatgt gaggacatag 142920 

atttgggagg ggtcaagagt ggaatgatat gatctggctg tgtccccacc caaatctcat 142980 

cttgaagtgt agctcccaga attcccacat gttgtgggag ggacctgagg ggaggtaatt 143040 

gaatcatggg gtcaggtctt tcctgttctg ttctcatcat ggtgaataag tctcatggga 143100 

tctgatggtt ttataaagac gagttccctt gcacacactc tcttggcctg ccgccatgta 143160 

agacatgact ttgctcctca ttcaccttcc accatgaagt gtgaggcttc cccagacata 143220 

tggaactgtg agtcaattga acgtcttttt tttttataga ttgcccagtc tcaggtatgt 143280 

ctttgttggc agtgagggaa cagactaata cactgcccag ttgatggctt tcctgtaaca 143340 

gacagagcta attttacatt tagaatcaaa gcacgcagag tcctgttgag atagcaaaca 143400 

aaactaagga tgattgttgt aaccttttct cacttggtag aatttaaaca caatcttgga 143460 

aactccagga aaaataacaa attaaaatgt tgctctcaaa cctgacccca catttcttca 143520 

aaagtagaat agagtcgtct tagaggagca gcttaggctt gtaagttgga tagctgtggg 143580 

tttgaatcct gactgatact aggcagttgt ataatcttca agactctata tctgatcttg 143640 

tttagcctca gttttcttat ttgtaaaata gagtaacatc tacttgcagt gctgctgcaa 143700 

aaattagagc taaactatat caggtcacta tatttagaat cattacaaat ccccaaaagg 143760 

caaagaaggt ccaaagaaag ccatttacag ggtgcctcaa ctttgagttt gtggctggaa 143820 

tttggatcta agagatagga attatatgtt ctcaaaagca gcagatgggc atgatagggc 143880 

cctaagcaat tttactacaa tccttttgga aatctctaat tgttctctaa agagttaact 143940 

tcaattatca ttagccatct gctgaaccaa tgggatttcc tctgcaagtg ccagcaagaa 144000 

tattcctgcc aaataaagag aaagtgcttt tgaaataaaa cttgtagagc ataactcaca 144060 

cgtaaatact ttcaaagtta agaggaaaca gcctgaggct agagccacca ttaatattca 144120 

gagcaaaata tgcatgttgt atgataagaa agagtgaaag ataagcagag aattaccagt 144180 

gaaggctaca tcatctgagt tggtttcaga gtggcctctg gatgacatca tgataccagg 144240 

gccagttggg attaaggaag actctctccc aaggcacatg ttcataaaaa gaaaaagcag 144300 

ggtactgtgg tcagccaatg ggatcaggaa attcaaggta cagaacctag tacttgtgct 144360 

actcttagct catcacatag ctactgccat attgcaaaat tcactgaaac caagtggaaa 144420 

aacaacagat gctaaaaaag ggaatttata gagatttggt gtagcatttt ccaaactcac 144480 

ctaatcatat taatcaggca ggattgttga aatagaaaat tttaggctct tccctggagg 144540 

ttgagtcaga aagtctggca tggggccgag gattttgcat ttttttaaac cttccaggtg 144600 

attcttctca tcaggcaggt ttgacattgt tacagtccag tggttcttaa agtattgccc 144660 

ccagatcagc agcatcagca ttacctggga actcattaaa aatgcaagtt attgggaccc 144720 

cactccagac ctatgaaatg gcaactatgg ggtgcagtgg gaagagagac agcaatctgt 144780 

tttagaagac ctctggtgat tctcatccat attaaagttt cagatctaca tttgtcaaat 144840 

gtggcccaga gaactagaag tggggagtgc agctgctgat taggaaattc tcctggccca 144900 

aattctccta ggactaagaa ggtcatgaat taaatccaga tactaatgtt gcttttccct 144960 

tgacttcatt atctcctttt ctatttttta aggagcagtt taattttgtg gcccttttta 145020 

actttcccac tgatcaaggc caatcccctt tctgcttgat agcaaggatt ctttattatt 145080 

ttcctccttg atcctcttgc ttctttgctc tcatcttaaa gacattgata gaatgacatt 145140 

ggtagtatgg tctctcattt ctcatatttc tgtcaaatgt gttttaatac tggaacgtat 145200 

ccagagatct gctataatat tttttaatgg caagttttag cagatcttgt cctccttacc 145260 

aagcctcact tttttttcac cttttggaag ggcaaggcaa tgcttaaaga tattatccat 145320 

ttttaaaatg gccatcattt tgaaggatag attctggcat caatgatatg caaatattcc 145380 

cactcaatgt acaaaagcag aaataataag ggagtcacta atcagctaat gagacaattt 145440 

tctggcacaa ctgtgaagaa agtgtattag tgttagtttc ttagggttga catcatgaaa 145500 

taccacatgc tgagtggttt aagcaacaga aatttattac ctcacagttc tggaggctgg 145560 

aagtccagga tcaagttgtt ggcactgttg gtttcttcca tgagctgtga gggaaaaacc 145620 

tgctccaccc ctttcttata gcttctgcca gcaagctttg gagtttcttg gtttgtagat 145680 

gcataccaat ctatgccttt aggttcacat agtgttctcc ctgaatgtgt gtgttcccac 145740 

tttttaaaga acaccagtta tattgattta ggggcccatc ctacctcatc ttaactaatt 145800 

ctatctacaa tgaccttatt ttcaaataag gtcgcattag gtaccaggaa ttaggacttc 145860 

aatatatgaa tttgaaaggg ggtgacaaaa tcaatttata acaaggaggg ttcatagagg 145920 

gaggaaacca aatctaaact ccaaaatcat aaagacctga catgatgttg tctgtgggac 145980 

ttaaagtgtt taaaaaattg aataaaaatc tcaatgacac gtcagccctg gctacaatta 146040 

agaaatctat aaaacataga tgaaaaaaat tgaagagggg ccgggcacag tggctcatgc 146100 

ctgtaatctc agcagtttgg gaagctgtgg cagacggatc attcgaggtc aggagttcaa 146160 

aaccagcctc gccaatatgg tgaaacccca tatctactaa aagtacaaaa attagtcaag 146220 

catggtggca gttgcctgta atcctagcta ctcggaaagc tgaggcagga gaatcataga 146280 

atcatttgag cagggaggtg gaggttgcag tgagctgaga tcttgccact gcactccagc 146340 

agcctgggca acagagtgag actccatctc aaaaaaaaaa aaaaaattga agaggacaca 146400 

aataaattga aagatatcct atgttcatgg attggagaaa acaatcatta aaatttccat 146460 

attaccccaa tctacagatt caatgcaatc tacagattca atgcaattct tatcaaaata 146520 

ctagtgacat tcctcacaga aatagaaaaa acaattttaa aatttatgtg gaaccacgga 146580 

agacccagat agccacagca attctgagca aaaaagacaa agctagatgc atcacactat 146640 

ctgacttcga aatatactac aaagctctag taaccaacac agaataatac tggcataaaa 146700 

atagacacat agatcaatgg aatagagaac caagaaataa attcatgcat ttacagccaa 146760 

ctgatttttg acgaagatgc caagaacaca cattggagaa aggacaatct cttcaataaa 146820 

tggtgctgaa aaaaatggat agccacatgc agaagcatga aactagaccc ccatctctca 146880 

cagtatacaa aaatcaactc taactggatt aaagactcaa acataagatc caaactatga 146940 

aactactaca gcaaaagata gaggaaatgc ttcatgaaat tgaactggga aaaggttttt 147000 

tgaataaaac ttcaaaagcc ctggcaacaa aagctaaaat agacaaatga gattacataa 147060 

aactaaaaag cttctgtaca gcaaaggaaa tgatcaatga agtgaaaaga aaatctacag 147120 

aatgagagaa atatttgcaa actatgcatc tgataataag ttaataccct gattatataa 147180 

aaaactcaac aactcaatgg ccaaaaccca aaaaatcaga taaaaaatgg caaaagacct 147240 

gaatagacat tttttcacaa gagtacatac aaataaccaa cagatagatt aaaaatgcaa 147300 

aacttcacta atcacctgag gaatgctcat caaaaccaca atggtatcac ctcactgcag 147360 

ttaaaacagc ttttttcaaa aagacaaaca tgctggcaaa ggaaagggaa ctcttacaca 147420 

cgattggtgg aaatataagg taatacagcc attatggaaa acagtataaa gtttccttta 147480 

aaaactagaa atagactacc atttgatcta gcaagctcat tactgggcat atatcaaaga 147540 

aaatgaaatc ggtatgttga tgatacatct gcacacccat gtttattata gtgctattca 147600 

cagtagtcaa gatatggaat gaacctagat gaccatctac agatgaatgg attaaaaatt 147660 

gttatacaca caaacacaca cacatgcaga cacacaatag aataccattt aaccataaca 147720 

cagaatgaaa tcatgtcagt tgaagcaacg tagatgaacc tggaggacat tatattatgt 147780 

gaaataagct agacacagaa agacaaactg cataatctca ctcatgtgaa atctaaaaac 147840 

attgatttca tagaaataga gagtaaaata gtggctacca aaggctggaa ggggggacaa 147900 

caaaaggttg gtcaattgct gcaacgttaa attatacagg aagaataagt tttggtgttg 147960 

tattacacaa tacagtgact atagaaaaat aacattgtac tacatattca agatagctag 148020 

aagagaagat tttgaaggtt gtcaccacaa agaaatgtct aaaatgatgg atatgataac 148080 

tactccaatt tgatcattac actatgtaca tgtgcctcaa aacatcacat tgtaccccag 148140 

aaatatgtaa tattattgtg tcaattataa atttaaaaat aaattttaaa aaggaagaaa 148200 

attcaaaagt ggtcagattt ctgaccctgt attatctgga agttttccct gcaaaaaaat 148260 

aaatagtaca aagtttttaa agcacatggt gggaaagata tttatgttgt tcataatgga 148320 

ttttaaatga tcaagttaaa tgaaggtcaa attgctctat ttatattgga gaggatgaaa 148380 

tgttgtagga atgcctgcag ttacgttatc aactcaggtt gacttcactg ctttgaatag 148440 

tcagatttct ccctggtagt ttccaaatca gaacaatata ctcatttagg ggttgaagtt 148500 

tgaaaggaaa tcagatgatg cccatttaaa agatgattaa ggtttacata attctttgga 148560 

caaggggaca ttcgaataga tgtatgatgt tattaccgaa aacagaggtt aatagttgtc 148620 

tcactgttgc cttcttgact cagactttct tatttgggga ttttaattta cgattctgtc 148680 

ctgtacacag acaaatcttc acaagaatat aacaaacagc tttacttcta ttgttactat 148740 

tattaagaca gagtcttgtt ctgtcaccta ggctggagtg cagtgacaaa atctcgcctc 148800 

acaggaacct ccgactccct ggctcaagcg attctcctgc ctcaacctcc caagtagctg 148860 

ggattacagg catgggccac ctcacctggc taatttttgt cgagatgggg tttcaccatg 148920 

ttggccaggc tgttctcgaa cccctggcct caagtgatct gcccacttcc gcttcccaaa 148980 

gtgtcaggat tacagctgtg agccaccaca cagcctatat ttatttataa aagtttcatc 149040 

ttgagtttgg gtcaactgcc tctgctggta tcttgactcc atagtccagt tgttggcacc 149100 

aattcatctt ggtgctttag aagcctctaa aggcagttca tgatcattca gaacattgct 149160 

cagtgttgtt tctaatgctt gtattgttag tcttatcctg acctttacgt tgtgccagta 149220 

aaattccatt gattatattt tttcatttca tcactgtatt tgtgtactca tgccccactt 149280 

tttaaagaaa aaagtcatgt ttgaaagaca tgtacttgtg ttctaagaag tgatgcaact 149340 

atttttggaa aaaaaaaaaa tgaaacttta agcatatttc caaagttctt tttgtatcaa 149400 

cacttcttgc tgtgttttcc cagttacggt ggtatttgac aaacacctgg ctgatactaa 149460 

tctggtacac agctggacaa atcattttct taaaatggtt cccccaaaag gctaattata 149520 

aatataaatg cctgtaatta cttagagtat atacaaatca ttataggaaa tatagaggga 149580 

actgcattcg tatgatccac ttaacaacat tcacgatatc ctgtaatgaa ttcacacttc 149640 

aacttcactc agacttcaaa attatacaaa aaattaactc tttctcatgg tggagatagc 149700 

tgcccaaacc tgtaatggct gtcctctaca gtgaagttgg aaatagctac ttgagatgcc 149760 

atagacagcc aaagtccagt taagatcaat cctagactgg gtgttgaaaa atttctttag 149820 

gtctttcagg tttacatttg gaatctggac agttgtccaa aaaataaatg tataattgtg 149880 

catagtgatg ggattagtga ccctagaata tatttctgta acaattccac ccttgaatga 149940 

atgataaaat caaatagggc caaatatata tcaagcaaga agttctgctt tgagaactaa 150000 

tgaccaattt ctagtgatat tatcagaagt gttataaaac tttttttatt tcctgtattt 150060 

ctactgggga aagaggacaa gggcaggatg gataactcca agtacttcca atctctacta 150120 

acagaacaat attagatcat gcagagaagg aacatgtctc catctgattt tagtattgtt 150180 

tttcttagta ggacttttcc cctctctccc ttcctcctta tcttccttcc cttcttcctt 150240 

tcctccatct ttcttctctg tttctcgctt tctctctttg aatacttact aagtgaataa 150300 

aatccacttg attgtgcact acttgggaat aagaatcagg ttatttctag aatgatgaga 150360 

atctatctga tgcaaagaga aaagggaagt aaactttaaa aaagtttata atctataagt 150420 

gctttatatc tactatgtca tgtgatagcc accacctttc tatgagatta ttattataaa 150480 

ctttcatttc agagataaga agcttgaggc tcatctctaa tttatggctt aattaactta 150540 

cttcctcaag gcctatagat ttatgtggtg ttattagaat tcaaactcaa gtttgtctgg 150600 

ctacaaattc tgtatttcca ctgtaagttt caaaacattt tcaatgttta caactgactg 150660 

caaatagatt gatgttagaa attatgttag ccataagaaa ataattatag tttcttaaag 150720 

aaatgatgag actaaaatct tagcttcctt ccctattcgc ttctctcttt tttcatatag 150780 

gtagagatta aaattctctg aaactgtggg tattatttta gccagaaaac atgacaatat 150840 

agaatacctt actttaattt cattttcagt agtatatttg tagtttcttt tttttaacgg 150900 

tcatgtgttt tttcttcctt ttagtgttga atgtagaaaa cagaatttca aattcccaac 150960 

tatgtaacaa caaaaaagaa atatttgtat tacatgatag caaaatgcca tcaagagacc 151020 

ctattgaatt tactttctca cacagagaaa actgtaatag tgaaagggga aaaaaggata 151080 

ttaaacttga aatcagaggt actggttttg gaatatagac tcttccacct atcatatacg 151140 

tgaatttggg taaatgattt aaaagcttta agcttcagtt ccatcatcta tgacaaagat 151200 

cttaatgccc atttgcagga ttgctgtgag gattaatatg aggagactat gttaagactg 151260 

tctgaacatt tttaagagta atgtcgacat acagcactag tactgccagt ccccactcct 151320 

gaccccacag aagatcctgc caaactataa tggtagtctt tccagcagat ctggacagct 151380 

tcacaaaatg aagcctcata aaagtctttt ataaagactg gtccaataga ccttcctagg 151440 

ttagtggacc caaaaagtgg acataattaa gctagatgga tcctcttggc cagcctgggt 151500 

tcaggtgaga gatatccact gcccttttcc acctaaggcc taaaatacta agttggagct 151560 

ttagcccttt aacttaattc ctgttaaaat gcagctatct tagtgagtga tttctatata 151620 

ctttcctggg agcagcgtgt gacagaggag tggggacggg acagggaaag catgagttga 151680 

acacagaaga gacagaaaag catgcctatg actaggagat gcttggtagg cagaaccgag 151740 

gggatgaatg acagtgttcc ccatttctgt agtctcttca gattcagcca tgcccatgtt 151800 

gtttatcttt tgctatactt ttagtctatt taccattacc cctcacagaa atagctattt 151860 

tcattgaaca tcatctgtgg tttagcatcc ttctaggaac tttgcatatt aaattatagc 151920 

aagcttatac tgttattact ctttttcaga tgagaaaaag aagactcaga gagcaagtaa 151980 

gttgcaaaga tagtattaaa actagttgca tttgaatcca aacctcttca ctttctgcca 152040 

actgtactgt ttgtcatatt tccttaaatt gaaagttcgt gttttccttc ctatcaagaa 152100 

tgtgaaggaa cctatcccag tcacaaagat taggatatat agtagcagca gcaacaacaa 152160 

caacaaatcc ccaagtctta gcatttaaaa atgacaaaag gtctttgccc ccatataaca 152220 

tgtctgttgg ggatcagctg tggggacttg gcagcacatt gtcctcatca gagactcagg 152280 

ctattggagg cttcaagcat cactagactc cactgcacac agaagggaag aactgtatgg 152340 

cagctcttaa atactgccag accaagtatg tgatgccaac ctaaagaagt atggttgttc 152400 

ctcggtatcc actggggatt agttacatga ccaccttccc cctaccaaaa tcccaggatg 152460 

ctcaaatccc ttatataaat tagagtagta tttgcatata acctatgcac atcctcctga 152520 

acattttaaa taatctctgg attatttata atgcctaata caatgtaaat gttgtataaa 152580 

tagtgattat actgtatcac ctttttattt gtattatttt tattttcata ttgttatttt 152640 

ttattatttt cttttctcaa tattttgatc tgtggttagt taatctgcag tttgcgaact 152700 

ctcagataca gagggcaact gcacattgtg ggcaagtaca aacctatcgt gtgctgaaca 152760 

gagaagaaat ggaggtactc gtgagcagca ttaatgtgta caccagaatc tcaacagtaa 152820 

agacagaata acatgaagaa aataactaca ggagtgctgt gttttaaaaa agcaagctcc 152880 

tccagctgag tttgtgactc taatccctgc ttattttgag cactttccat gtgttgattg 152940 

actcggaaag gtgggagatt accagcaagc caggtcattt gggcaaacat gggcatattt 153000 

ttagcaaagc tgaacaaact ggttggtcac tcgaactacc caatttagac ttatagtaag 153060 

aatagcacat ggttcagaat tgccaagact gctgctttag tcaacagaaa ttttttcata 153120 

tgcatgctgg taatgcagtg catctctgga agaaatgcaa gagtatttta acatttggtc 153180 

cagaagaaat atgtaaaggg tgtttgtaga atttgatgcc ctcttcagtg acataaggtt 153240 

atgggtttgt gaatggaaaa tctgttattt gttcaggtta ttaaaacaca ttctaattca 153300 

acatcattag actggcaaaa aacttccact tttaggactc tataaaacct acattaacct 153360 

tgaattaaca aaactaggaa gtgtgatgta gtagaagggg ctttaaggaa ggcagggttc 153420 

ataaccccat cacgaagtta cttactacaa gaactttaat tctgaatctt tcaggccatt 153480 

tctcatctgt tatgtgagaa tattaataag taaatgtggc aagtactgtt gactctacct 153540 

tcaaaatata tcttctacta ttcatttctc tccatctcta aaactcctaa ttcaggcaaa 153600 

actaatttct cagctagacc accacacctg ctcctaatac ttctccactt gcccccacca 153660 

gcccactcat tactcagcag acataaggat ctttcctgcc ccaggttctt tgcacatgct 153720 

atcccacttt tttccctacc tcctgcatgc tacagctctg tttcttcctt tggttaacag 153780 

cttaagtact ttctcgaagc attttttctt gatattccta tctacagtag gtttctctat 153840 

tatttactat ctcagctcat ttgtttcctt catggtgcct gtcctattta gtaatttgtt 153900 

tctgtttgtc tgtctacctt tttgttttct atattagaat atgagtttcc caagggcaga 153960 

gacaggcttt gtcttgtctg tccttgaatc taccaagcac agtgcctggc acattggagg 154020 

tgctaaggaa atattagtgt aaagagtgaa ggaattgctg tgaggaatat gtgagttaat 154080 

taagtgcatc tttaggtacc tgggtagtgc tcagttaata ttgttattct tttccttttc 154140 

tttaccagtg ctgcccaatc aatctccttc ttctactccg tatatttccc tgctgaaggt 154200 

atactagcat gtttccccat catatgcaaa tatcctacaa atccaaagta aaaggcaaag 154260 

atattgaaat acagggaaca gaagaaattg ctcctgactt tgatacattg ctcttttaat 154320 

acatctgtgt ttttgtgaat tatgcactga aactcttaca tgacctttcc tacaccaaat 154380 

ttagaggttt gtaatcagca aacaagtgtt tgtttcttat gatttctttc tataggttat 154440 

acagtatctc taagttttct tgaacaatgg tgttaaaaat aattttaatg ctttattgtt 154500 

attttctttt attattcaaa aatgggtgga aaatgaagat gcaaaaatgc agaaagtagt 154560 

tataaaaagt taggtaagga acagtagagt taagacaaag gtaaaagtaa ttaagcatgc 154620 

aatcgatagt tagcatttag tttctattgg acacattaaa attaaactga ttaatagtgt 154680 

cttcatttac aaaggaagca aatttaaaga atagcatgaa atgggcctgg cacagtggct 154740 

tacgcctgta attccagcac tttggaggcc gaggcaggca gattacttga gatcaggggt 154800 

tttaggccag cctggtcaac atggtgaaac cccatctcta caaaataaaa acaacaacaa 154860 

aaaaaatgaa aattagccag gcgtggtggt aggctcctgt agtcccagct actcaggagg 154920 

ctgaggtgag agaatcgctt gaacctggaa ggtggaggtt gcagtgagcc aagatcgtcc 154980 

tgggcgacag agcaagactt catctaaaaa aaataaaata aaaagaagaa gaagaagaat 155040 

agcatgaaat gctggaattt attgggtatt atatctaaaa ggagaggcat atttatgaaa 155100 

tttaaatcag ttttagctct ctgtagaaca gaatccccac tctaaaatac attatctctt 155160 

gcatatttga ctttcttata tgtttttagt ctgattttgt ttgaaagtag tggattgcca 155220 

atacgcttgc tcctttttcc cgtgaaaggt gagcaaaccc accctgtcat ttacttatga 155280 

ggaacttgtg acccagtgag gtgaaggaat tagtcctact ggaatgcctc cattctttgt 155340 

aatcagttgc ctgaattatt ttagagtctg tttattttaa aggaatcttt catagttctg 155400 

gcaaaaattt atttataaat ggctttgagt ttgaggtaga aaatattaac tattagacag 155460 

ctgattgttc tagatgtgca agaagtaagg cactcaggat gtccttaact ttgttttcct 155520 

cttggttggt taatccctcc atatgcaata ggttgtttac ttcaatctgt ttctcattta 155580 

agaccactga aagttaatcc atggagctca cactctgtac cttctgaaat aactctaaca 155640 

aatcaagtta aaattttcct gacccttctt cgtgtcttcc ttcactcctt aactcctgcc 155700 

agtacgtgct gggaatttgc ctctggactt tgacacattt actcttttag atttgttatg 155760 

tcccacatta actgaacttt gccatattct taatgttgat ctggatttgc agaggtggtt 155820 

ttggagttct gcccatattc ccagtgtcta atccccagca agcctctctc tattttcctc 155880 

cactatccac tgccttacat taaattacca ttatgctagc tacatttcaa gttcttggta 155940 

gccacatgta actactggta atcatattgg acaggataga aagttgtatt gaacagtgct 156000 

accctagaat atctagacct tcacctacct gtgccagcgt cagtatctag aaaactagaa 156060 

tgtctcaagt gtccataaaa tcatttggca agttaagtct cagtaaaaat gtccttgatg 156120 

tttttttctt tgtagttaat gatgcatttc attgctttcc aaactctttc acaaggctta 156180 

caaaatccat catgaccttt accatttgtc taacttcatt atttctcttt cccttgaact 156240 

gtactctttt gaactatttt acattccttg actccaaggc taaacttgct actccttctg 156300 

tctggaatat tcttcctttc ctgttcagtg tctcaagtat tctctggtgc tatgggacac 156360 

tttaagagga ggagcttaat ccctttggac aacttagaga tgtggaatta atttaatgtc 156420 

gcttgatgat ttctatcatt caacatcaga aagcaattta gggcacaggc aatgtgaaac 156480 

tgcattttgt acacagaaaa ttatgaaata ctaaacttct taagggagga gccattaacc 156540 

tcagaaactt agattgttcc tattgtttta taagaaacaa atctttcgta tatttatccg 156600 

tagatgtgtg tttgtgtatg taactccctt ccgccgcata aacttttccc aacactcctt 156660 

taccccacgc ctgaagagac aatggaggag agaatggagg agctctgtga ataaaatgca 156720 

aactctattt gaatccagtc caatatttaa ctcaaagaaa aaattttaat actagccaga 156780 

acttttgaga agcgtgctct aattcgtcct ttctttttct ttatgacatc tgtctaaagg 156840 

gaacatttgt ggaagagact catccacaga gagagtaggg ttggcagaag caatgcagat 156900 

aggcttctgc agataggctg tggtccttcc tgtaaggcag catttcacaa ttcagatgaa 156960 

atgactcttg tcatttttct tttcagttat tgcaaaatct gcttcagtga aacatgctta 157020 

tctgtttctg tataattaaa aaaaatcttg tacaagtaac gaagtacatg aaatcaaaca 157080 

cacttgctaa actaatggca tatggagtta ttatgcacgt gagactcaag tctcagtgat 157140 

tagattatgc ctctcccctt ccattatgac tgcaaattgg tatgcagcca ttttcaaatt 157200 

agcgactgta ttagttagtt cacagcctgc tgtaaaggtc ttcttgagac tgggtaaatt 157260 

ataaaggaaa gaggtttaat tgactcacag ttccacagag ctggggaaac ctcaggaaac 157320 

ttacagttaa tggtggaagg ggaagcaaac acatccttat tcacatggca gcaggaagga 157380 

gaattgtaga gcaaagcagg gtggggaaaa gtccgttata aaaccatcag atctcatgag 157440 

acctcactca ctatcacaag accagcatgg aggtaaccac ccccatgatt caattacctc 157500 

ccactgggtc cctaccatgt ataattcaag cagagatttg ggtggggata cagccaaagc 157560 

atatcagtgg caacgtataa atctcaaagg ctcatgtcta gttttgcaga gcattggttt 157620 

tatatgatag cagttactgt ccctatgcag tgaagtgtga tacaggcttt ttctaaggca 157680 

ttacaggaaa cctctaccat ttcatcacac tcactatgct aaaagccatg atgaaatcca 157740 

tgactgtgct ctctagcact taattatgtt ttgattacta caaataattt atttttttac 157800 

attttgcttc ttagaattcc cagccacaaa cacccattca tcctatcaaa acagaacaaa 157860 

ccatagcaca tatatgtaaa catttttaga acatgtacac gtagataaac aagtgtatag 157920 

aacgtaacaa agtttctaaa ccatatcaca ttgtttattt tagtcaccag tactcaacaa 157980 

tgattcaaga aattcagacc ccaacagcat taatgtctca gcaatgtaac ctgaaactca 158040 

gcaacccaaa tctacagtag tgggaaagcc tgggtttgtg cattgtccga tgtgaaggtt 158100 

aattcgaatt atttttccag acatatggag ttctccttta ctttcagaaa aagaaagaaa 158160 

gaaaaagttg ttgcacacct actgtattag tccattttta cactgctgaa aaagacatac 158220 

ccaatcaaga ctgagaagaa aaagaggttt aattggactt acagttccac atggctgagg 158280 

agatgtcaga attatggtgg gagctgaaag gcacttctta catggtggta gcaagagaag 158340 

atgaggagga agcaaaagca gaaacccctg ataaacccat cttatcttgt gaggcttatt 158400 

cactatcatg agactagcat gggaaagacc ggcccccatg attcatttac ctcccactgg 158460 

gtccctccca caacatgtgg gaattctggg agatacaatt caagttgaaa tttgggtggg 158520 

gacacagcca aactgtatca cctactttag cttaagcatg gtgttagata tatccacaga 158580 

agttaccatg tttaatttta acaatgaccc tgagagtaag aatttttatc cctattttta 158640 

ctgatgagga aaactaaggc atagagcaga tcattgactt ccccaagaac acagtgctga 158700 

ggctgagata caaacctagt cctggaactc ttgagtttat tccttttcta atgtaccgtg 158760 

ctatcccagg tcactgaaaa cctacttatg gagttactgc acctggaatt atataagtct 158820 

gctcaaggac aagcaggggc aaatcaacca gtgaaaataa agtatagcag aaccgggaac 158880 

ataagacctg tgagcatgca tatctgattc ctggaatgca aatggtcagg accccagcca 158940 

aatgaactga aggttagttc tgggccacag tccaattgga aatagaagtg tcaaatagaa 159000 

aacctatagc agaagttccg gtaggcaaac tgtgccagtt gagtggacta ttggagatca 159060 

ttttggtgtg gtgggtccat gaacacccag gacctaccag atacaccagc tttacagcaa 159120 

cggactaact aattccagac tctgcagact ggcttactat atgcctgcct gttaaattgt 159180 

gtaagatgtt ttatgcagat tatctcaatg aaacctcacc acagcaggaa gaagcaagat 159240 

tgttttatta cttgccatag tttaacatgg caggttaagt agtggtaaag agcacgcact 159300 

gtagaaccaa gtttcctggg tctgtcttct ggttcttacc aattctgtta tcatctattt 159360 

ggggaaattt gcttaactct gtctgtgacc cacttcattt gtaaactggg agtgagatag 159420 

tgctcaagtt ttcagctttc caagagtata aaggcttcaa atggggcctg gctcaggaaa 159480 

ttgctaggca agtgtatgat aaataaagga gaaaactaag taacttgggt aaattcataa 159540 

aagtgatatg tggtggggct gggacttaaa tccagagata tctgactctg caagtgaggg 159600 

acctcaggga cttcacctct gaggggacta gggaaagcag atatcaacac aatcccaaga 159660 

gtcctcttat tttctctctc atcctatatt ggctaccgtt tcgatggaag tcatgaaatt 159720 

actaaaagta atttcagaat ctcctttgca taaggccctt tccaatgtta gctgtgcact 159780 

taaaatattt aactttgcaa taccaaatcc acctccatct tacttcaata ctattttgca 159840 

ttctctggtt tctgaggaaa tcacaaaaat gagccctagg caaaaatttt aggttagagt 159900 

atgaagaacc ctattgagtt tatgcacatc agtaatgcct tctccaaaat aagaaatatg 159960 

ctttcaattt acatcataaa atgagatttt ttaaaaagtt aaaggtttta ttgatgcact 160020 

tccttaaact agtatttcaa aagataaaaa cagcttttct ctgttaagaa ggaatggctg 160080 

ttttatgagt gttttcttct taacttgaca tgaagcaaat ttaagcaata tatagctaga 160140 

tctgttcagt ctcaccaata tatgagaaag taaattttca taaaaaaaac tttacctgtg 160200 

ccaaatcaag tcctattagg ttgtataaga tctgttatcc catgactccg agtccttgga 160260 

atgcatccca gttcagtcta gcagagttac tttctctgga cttcatatgc atagacatac 160320 

gcttggtaga cagagacaca gtgtgaattt gaaagcaggt attttcaagc aaaagccatg 160380 

aatgacagtt ctaaatgaga gcaaaatctc ctgtgttcct tttcacaaaa ctgcaaagct 160440 

gtaagaacaa cacgggtgtg ttttgttgca ttttcttgga tcagcttttg tctcactgtt 160500 

actagtctct ccaagtttga agaggccatg tttagtttgt ttttcaaccc agaaaatata 160560 

agaattatat catgaagtga tgcaatatgt ataacagtag ggaaattaag caaagatttt 160620 

gaagtcaatc aagcccctgt gggttcgaat agttcctcag ccactagcta actataggac 160680 

tttaatcaag ttatttaagc tccccaacag attacagtag aaacaatctg gagacttgga 160740 

gacctctcag gaggctactg cactggtacg gatgagaagt tctctttaga atggagatac 160800 

tacaatgaag agggaaaatc tacttatgat ttggcctttg ggaggcaaat attctgattg 160860 

gctctggtga caaggaccca aaaccctttt tacctaattt ctctgatgaa aatccactga 160920 

ttatagagca cagatttagt acttctgatg aagaggtaag gctataaaaa gacatatcca 160980 

caaatggcac aataggtagc atttttcatc ttcattcagt ctcagcagaa agttcttgag 161040 

catccactta tttcagatac agggttaggc attcaatttg gtgttaggta tacataataa 161100 

aacttcacca gctcaaagac atataaagat atgctatcca tgtttatctg gacttttttg 161160 

tttcaaacaa caccaaaatt cagatttaaa aaatgacatt tattgatgaa ataactgaaa 161220 

agtctaggac ctcagaaatg catggacctt ggtgctcaaa tgatgtgtga agaatctggg 161280 

tttttctgtc ttttgccctg acttcttcta tactggtttc attctcaaag gtactctttt 161340 

catggtggta acagggcaac caggagcttc aagctgttgt ctttactatt tgagaaattt 161400 

cagtggtaaa aaaattgctt tgacttctca caatttctca gaagttctag caaatattgc 161460 

tgatagagtt attgacctag tttaggtcat atatctctat gtcccttctt gagctaatta 161520 

ccttgtacta ggcttgaccc taatgagctt tatagactag aatagaggaa agtggctcca 161580 

aaaaagatga ttgaataatt attactagca tcaaggaaga atgacttgag tgattaaaaa 161640 

ttacatatgt caactatact aatttaaaaa ttacatatgt caactatact atctaattga 161700 

tttaagtaag tactcttttt tattgcaaat gacagaaatt cattccagat taaaccaaat 161760 

gaaatttgat ataaaaatgt catggaaccc aagagcaagg agtgccatag gcctcataag 161820 

gaaccgaaat gagaaaatga aaattaactg gtattactgc tctctctctc tctctctctc 161880 

tctctctctc cctctctctc ccttttcaca tctgtattta ggatatgtct ttgtcttcat 161940 

tcaaatatct ctccatctca atgcgcatga ttacccaaca attctcagtt tcagccactc 162000 

agaagagatc aaaactagtt tccctcactc tcaattcaaa atttgtggaa aaaaatatta 162060 

ttagttaaac ttgtatctag tgaccactct tgtccaacca agtatgacat agagactggg 162120 

ttaaaccaac tgcttggttt gagggtaatt cttggaaaaa gaaggctatt gtaatgttga 162180 

caaaatagca acagcagtcc actgcaacat cacaaccaac tttactgaca gaagatcttg 162240 

ttcctgctat aaaattcatc tttatcttct ggactttagt aaatctgcaa aggtatagaa 162300 

actatacctt taaaaatgtc cacaaaacaa tatgaaaaat ggcaagtcaa tctccaatga 162360 

tgaaatcgtg tatcaaaatc aggctacatg attgtcaccc tggccatata tgtaaagaaa 162420 

gtagacaaca aataaaaact caaactactt gattatttgc ttgctggtaa gttgcaagtt 162480 

gtggagaaga aattaatcca ttctaatgaa catttatcca tttcttatga atttccaaac 162540 

atattgtcag gagttaaggc agcagatttg tagacagagt cactttccct gaaagactga 162600 

cagactagtt gaggagacag acaagtaaat cactgattga aaaatagcaa agatatttga 162660 

taaatggggt atgctcagga tgctatgaca tttcagagaa gaaaatatcc tgcttcaagg 162720 

ggtatattag tttactaggg ctgccgtaac aaaataccca cagactgggt gacttaatcg 162780 

aaatgtatat tcccacagtc ttggaggtga aaagtctaaa atcaacatgt tggcaggttt 162840 

agttttgttt gtggcttttc tttttggctt gcaggtgaac accttctctt tgtgtcctgt 162900 

gcctgcacat cccttgtctc tctctgcatg ttcaactttc cttttcttat aaggatacca 162960 

gtcaaattgg attaaggccc accctgaaga cctaatttaa cctaattact tatttaaagg 163020 

ccctgtctgc aagtacagtc acattctatg acactgagag ttaggccttc aacacacaaa 163080 

tggtggggtg agggcgctgt gcacaatcca cccaaaacaa gagaaatttt cgagagtagt 163140 

gttgcttgac ccagtcttaa agaagagggt ataaccctgt ggatagaaca gcaggaacaa 163200 

aggtataaat gcaagagtga gcattgctta tctatggaat tttaaatagt ctggtaatgc 163260 

tggagcttag gatgcaaatg aggaattgaa aattggtaaa acatgaagtt ggaaaggtaa 163320 

ttaaggattg aattataaaa ggttttgtac tgagatgggc taaattatgg ttaaaaaatg 163380 

cctcaagata taatagcaca aacacaacac aagtttattt ctccttcaag gaatagttca 163440 

gggttggtgc tacaggtcca ccagcaactc tcttccacaa agtgattcct ggatcagact 163500 

ccattcatct caaggctctc atctgtgtga tcatgcctgg gtggctgtgc tcaagacttt 163560 

cactttaagg tctgaaccag taagtggcac acttcactcc tgctgtcctg ccattgctga 163620 

gaactattca catgacctct cctggttgct gggttatggg gattgtaaca taagggggtt 163680 

ggctggataa ccccttccca gctgtaattc tattattatg aaaagacagg cattttgtac 163740 

ataggagctg tcgtcatcac agtcttgtaa gtcatagtaa ggagtttggg ttcttataaa 163800 

tttgaggatt tttaaggagg acggtcgtga ttaaatttta attttaaaat gtaatgctag 163860 

tagcattata aagaaagaat ttgtgaggca atgtcagaag cacagatata atattgagga 163920 

agctatttca gtaattctgg caagtgattc tgaattaagg cagtgctagt aggagtggag 163980 

aagacaaaac agattccagt gatattttag aaatagactc atcatgactc ctgactgatt 164040 

tcttttgaga ggggaagaag aggaaaattc tagtaactct taattcctgg cttggatgaa 164100 

tgatgagatt ttggtaacat taaatgagga ggagagggct tgggaaaggc tcagttaaaa 164160 

acatactgag gtttgagata tctgtggaat atcaaagcag aggtgccagt aagtcataca 164220 

cataagacat attttcaggg gctgaaaaaa tacatttcat ggttattata atagtgacaa 164280 

aatgtaattg gaatcacatg gagatgaggt caactatagt aatcatagat ttatataatg 164340 

acataagaat ggtgatttcc aattttcatt ttatgcccaa acaaaaaagg tcttaggcaa 164400 

aacagaagag tttagatact accaaattat gaaagcagtg gtttagccat tttataagta 164460 

ttcaatggta aaaaacacaa aaatttcccc ttaaaattca gagtttcaaa ttctatagaa 164520 

agatattcat aaaacagaaa atcattacaa gttagaggag tttttagact tgacaactct 164580 

ttatatatga gtattgcatt agatatgcac tgtcattgaa gtagacattt aattaataac 164640 

cctatgctgt tgcaagtatc tatcaagtat attgaaaaaa caagaagcaa ccaattttat 164700 

tcttccaact atcttgctgg caaataactc gctcccttct ggaaatgctg aatcatttat 164760 

ctttacattt ttgttaacct gctcattttg taggataggc tcaagatagt tactactaaa 164820 

ttaaagatga tcatgtgacc atgagttaga aacatgaatc taagacccaa atgcaagatc 164880 

ctataacatg actgttaaga aaatgacaaa caactaagga atacccaggt gatatggttt 164940 

gtctgtgtcc ccactcaaat atcaacttga attgtatctc ccagaattcc cacgtgttgt 165000 

gggaggggcc cagggggagg taattgaatc atggggcaag tttttcccat gctattctca 165060 

tgatggtaaa aaagtctcac aagatctgat gggtttatca gtggcttctg cttttgcttc 165120 

ttcctcattt ttctcttcct gccaccatgt aagaagtgtc ttccacctcc tgccatgatt 165180 

ccaaggcctc cccagccatg tggaactgta agtcaaatta aacctctttt tcttcccagt 165240 

ctcgggtatg tctttatcag cagcataaaa acagactaat acagtaaagt ggtaccagta 165300 

gagtggggca tttatgaaaa gatacttgaa aatgtggaag caactttgga actaggtaat 165360 

aggcggagat tggaacagtt tggaggactc agaagaagtc agaaaaatgt gggaaagttt 165420 

ggaacttcct agagacttgt tggatggctt tgccccaaat gctgatagca atatggaaaa 165480 

taaggtcgag gctgaggtgg tctcaggtgg aggtgaggaa gttgttggga aatggagtaa 165540 

aggtgactct tgttatgttt tagcaaagaa actggtggca ttttgcccct gccctaggga 165600 

tttgtgaaac tttgaacttg agaaagttga cttagggtat ctggcagaag aaatttctaa 165660 

gcatcaaagc attcaagagg tgacttggat actgttaaaa gccattcagt tatataagag 165720 

aagcagagct taaaagtttg gaaaatttgc agcctgacta tgtgatagaa aagaaaaatc 165780 

catcttctgg atagaaattc aagccagcta gagaaatttg cataagtagc aaggagccga 165840 

atgttaatcc ccgagacaat ggagaaaatg tctccaggct atgtgagaga tcttcatggc 165900 

agcccctcct atcacaggcc cagaggccca ggaggaaact gatttcatca gctgggccca 165960 

cagtccctgt gttgtgtgca gcctagggac ttggtgtcct gtgtcccagc cactccagct 166020 

atggataaaa ggggccaatg tacagctcag tctgtggctt cagagggtgg aagccctaag 166080 

ccttggcagc ttccatgtgg tgttgagcct gtgggtgcac agaaggcaag aattgaggtt 166140 

tgggaacctc cacctagatt tcagaggatg tacagaaatc ccggatgccc aggcaaaagt 166200 

ttgctgcagg ggcggagccc tgatggagaa cctctactag ggaagtgcag aagggaaatg 166260 

tggggtcaga gcccccacac aggggcccta ctggggcact gcctagtgga gctgtaagaa 166320 

gagggccacc ttcctccaga ccccagaact gtagatccac tgacagcttg caccatggtc 166380 

ctggaaaagc tgcagacact caacactagc tcatgaaagc agctgggagg gaggctgtac 166440 

cctgtaaagc cacagaagtg gagctgccca agaccatggg aacttacctc ttgcgtcagc 166500 

ctgacctgga tgtgggacat ggagacaaag gagatcattt tggagctttt aaatgtgact 166560 

gccccactgg attttggact tgcacggttc ccgaaactcc tttgttttgg ccaatgtctc 166620 

ccatttggaa tggctgtatt tatctaatac ttgtacccct attgtatcta ggaagtaact 166680 

agttgccttt ggttttacag gctcacaggg ggaagggatt tgtcttgtct cagatgagac 166740 

tttcaattgt ggacttttgg gttaatgctg aaatgagtta agactttggg ggacagttgg 166800 

gaaggcatga ctggttttga aacgtgagga catgagattt ggaggggccg gcgtggaatt 166860 

ttccatatgg tttggccatg tccctaccca aatctagact tgtatctccc agaattccca 166920 

cctgttgtgg aaggagccta atgtgagata attgaatcat gggggctggt ctttcctgag 166980 

ctattctggt gacagtgaat aaatctcatg agatctgatg ggtttatcag gggtttccac 167040 

ttttgtttct tcctcatttt tctcttgccg ccaccatgta agaagtgcct ttcacctcct 167100 

gccatgattc tgaagcctcc ccagccatgt gccaccgtag tccaattaga ccaccttttc 167160 

ttcccagtct caggtatgtc tttatcggca gcctgaaaac agactaatag accagatgtt 167220 

tgaaaatatt tgaaatttct tagataatat taatgaattc aggaaatgaa aatggaaaat 167280 

gttttttttt aagacacagc attatcattg agtattttcc aaaatattta aattcttttt 167340 

cagtgagaac cattatagta cattttataa atcattgtaa ttttagtaaa ggtaacttac 167400 

aaattatatt tgagttcatt gtactgaaca actccatggt gatttgactt tccctgtcta 167460 

gtctggtact caggctcaag tatgatgttt tggtattgac ccttgggcac tgaatttgat 167520 

gtattagctt ctgatgctct tctaagttct gattttctat ttttatttct atagcatgaa 167580 

gcttttaaaa taagactttt gctaaaattg acattgacac ctcccacccc ccaccaaaac 167640 

acacactctg ttctttaaag aggagagtgt aaacagtatt tcaaaataga catcttttaa 167700 

tttggactgt aaagtctttc agttatacaa tttgagtttg actccaaaat gtcatatttc 167760 

atctcaaaat aaaggccaat actctaaata agaactaact cttacccatt tggtgggaat 167820 

caaactataa aaccaccttt ctattttttt ttaataaaag tgaaatatgc ttaaaagcaa 167880 

aatgagacaa ttgcttcaga tgatgcataa acataataaa caatgattaa cttttatttc 167940 

tttaaaaggg tattctattt tcatgtttta tatttaatta accattaaat aaatggttgt 168000 

aagatgataa agaaacagta tgtttttaaa agggatatag agagtcacag cactatgtaa 168060 

atagattttc tatgtgagag tgaccacttc aaatgactaa ctcacaagtt tccttgggac 168120 

taatgatacc taaaaggcag tttcaagtac atccaaattc caaattctca ggatcttctt 168180 

cacctaacta ttccttttga ttttctcagg gattcatctt ggtccacttt gcatagtgta 168240 

ctttatggat tatgtggctt aaatttatgt ccatatgctg atgattccca agtctctgtc 168300 

ctgttcagac ctcccacctg cacatccaac agctggctgg acatcatatt caatttaacc 168360 

ccacacctag tgcccgccaa ataaatgatg tccattaaat ggtttattgg gaatgttaaa 168420 

tgctttacaa aaacactgga ttataaacat gtttggcaac acaaaataaa aaccacatca 168480 

gcttacagca attttcatcc caaattttca actgccataa gtaatttcca cctgttatcc 168540 

ctccctcacc caaaattcac tatgcttata atcataacat tcccctctat cttactctga 168600 

gacaaatttc tagatctgat cctaatttcc tcgtgtcttt aaatggcgcc aaccttgttt 168660 

tgggccaaag gagccctatt caagtgtaca agttgggaaa aatatatttt gggcaggaac 168720 

ttcttcccct tttagatgct gtgtttttct gctcttgtcc cttcattctc ttcccctcct 168780 

actgaaatat tgctttcagc cagttgtcaa tttccttctt tactggattt taattgatac 168840 

agtatttact ttcctaggaa actgatgaaa aaaactcaaa agaatgactc tgcaataatg 168900 

aaattttaag cattatgcta aggataaagt agatatactt ggggagtgag gtctttcctg 168960 

ataccttcca aataatacag attccactac agagaagtat gaatttacag tgaagaacac 169020 

ctaaaatttg tctaagccac ctttgttctc ttgtgttaca tagtcttacc acaaacttcc 169080 

taaaatccta ttttatttat gttgctgtcc aattgaagaa catacaaagc ctcttccatt 169140 

ttgtaggcca ttgcaattta aaatgtctgt cagatcctca gtctgatctt ccctttacag 169200 

tcattttttt tcttcactat gtaaagtatc cagactttac actttttgga attgtactac 169260 

aggattaaaa tccccattct atacttgtta gtaaaattgt ttcattaaat gatgaattaa 169320 

taactgaaat aattaatgaa taaaacattg ctgtgcctgc tctctgcatg ccactactac 169380 

tctcacacca gcctctacac ttttgtgtgt gctattactc atacctggaa agtgcacttt 169440 

ctacctctgc agctatggct gtagtgtgca ctaaaatcac ctagagggct tggcaaagca 169500 

cacagtgctt ggtctcatcc tagcccagag cccaagggtt tgcactcaag caagttccca 169560 

acagatgtta atgatgctga tccaaggacc acactttgaa aacacagttt agagctcata 169620 

ttatctagag ttctgagatc cactttgtat tatttcacat gaatttttgt gatgtccttt 169680 

tctcatacta gatgtttttc atacttctag aaacttgtta cgtattggtg cattctccaa 169740 

aaacttggtg ctctcacagc gttagtccta accatgctga actttttaac tccctgtgaa 169800 

aagaccatgc atttttgtaa tttcctgcta ttcccttttc ccagcttact tcccattcgt 169860 

ttcatcttgg taaaatctaa gacctagttc tactgtcctc tcttttacca agactccttc 169920 

aaatttcttg gaaatctcca cccatcccaa tatctttgat cccatggatc tctgtacttg 169980 

tcaagaccac tgagaatatc tttgcatgca cattctgaat gcttaaaagg cagaaagcag 170040 

aacatatata tatatatata tatatttata tttgtatcct tagtaccaac acaatgtctc 170100 

aatagaagta ttttcaaagt atcccaatta tttgtaaaat atttgttaag taaaagcaaa 170160 

aataaacaat aaaagcaaac caaaatattg caaaaaggaa tgtgaactta catactgagt 170220 

tgtcatgcag aatattgaaa atcagagcaa tttaggtaga ctctcccaat aaggcacaac 170280 

ctcagcttct attcatggct aaaacatgcc agatagtata ttgatatatt tattgctatt 170340 

tatgtatata aataaaaact gagaagaaag agtaggcaga aggaaggaag aaatacctct 170400 

gcttagtcta aataatactg actagatgat aattagagga ggttaaagaa tatttagatt 170460 

cttgtatatt ataaatgtgt aggaaaaaag cattgctgat gtcattgaca atgagaactt 170520 

tctgaaaata gctcctatga cctcttatga attatttctg aatttaatgt gcttcttccc 170580 

aaacacagat ttgattcttt gcctcaaatc ctgtagatac tttcttgcac ttgactttag 170640 

gatcgaggca tcttggtggg ctcactatgg acttatttct ctttttctat ctccagaata 170700 

taaaccacat gtaacttcaa caatgctttg tacaagatgg atctgtttag agctggtgat 170760 

caacatttac cttgaagggc caaaagggaa agtttagaac tgctaggtta aacaaggtca 170820 

atttgaggaa gcaatcattt cgacggctga cattatgtct tgtaataaac ttggccaact 170880 

gttttttgtg gaaattttat tgtttctgtt gttatggctg cttctgtcag ggaaggtgat 170940 

ctggacagtg ttttagaaag catgcttttc ataattgaaa tgataaatca tcttatgtaa 171000 

ctatcacact cacttatatc ttcacattga ggtaggcaaa tctctggaaa gtaatgttgt 171060 

gtgtgtggcc tgtatttatg tatcaatgga gacatcctaa ttttccccac agttgatcca 171120 

tgagcatatt tatagtttag tatttttaaa tctatgttag tgatggacag gccactttca 171180 

ctgatatgga aactatgcag tgagaaactg agtttcccaa gcacagagtt aatgagaaac 171240 

tacagagtca gaggatatag aagattaaaa taagctagtg ttgccaaact aaatttcctt 171300 

agcagaagta gctgaattcc tgaaagggag ccagtcactt tgagacatgt gttttattta 171360 

cgctgaggca tcttcgtgat gatgcatatt actcctgtgt atactcagag acacatgact 171420 

gtgaagaaaa aaaaggaaca atatgcggta gcctaatgtt gttgggtgac ttgtcaaagt 171480 

cttggttgga gttgttggtt gagattattt tgctttgtgg gtagtttagt gtgtgctcta 171540 

atttgttccc ttttccaggt aattacgagt ttagttttct aatttttggt ttacaatatt 171600 

gtcaagataa ttaaataaga atatattgtg aagagattag cacaaggctg gcatatatac 171660 

attgccagta aatggagctg ttattataat tgtgagaaaa atgagatatt tgaagatttt 171720 

attctcaggg acaggagcca tcctattctt ccatgtgcat acttacttca gcacttagag 171780 

catacttcaa cttttcaatt aatttccatg aaagagtctg cctcacctat ttccaatgcc 171840 

tggcagtact gtcaccattt gggggacagg gtagtaaatt aaaaagttaa tgtttctcca 171900 

atttctgagt taaaaaaaac ttccattacc ccttccaaag tcattatttc taaggatagc 171960 

taggcattgg aagaaaaagt atagagtgac tctagctatt aaaactaggt gattataacc 172020 

gctttcactc ccagtgtttg ccagaggaca aattgttgcc aacagatgaa caaagaaaag 172080 

ggtcttctgc ttctgaagta gtcactttct cccttcatgt tcccagcaac tgtttatttg 172140 

gtacctccta tgcgctgagc ctaggcaaat aaaaatgaat ctgagatcat ctctgtgctg 172200 

cataaaaact ttgcattgtt taatgatgtt tatttgggga aaatatttgg gaaatatatt 172260 

aaatgatatc ggcaaatatt aaggagaact tactttttac aaagcacagt gactttgagg 172320 

gaaaagataa taaaagaagg tatgatcttt tttatgatct ttttatgata gggtggagga 172380 

aatggaatta aatctaggaa actcagtgat agcagtcagt cacaagcaag aaataaagtg 172440 

ttatgagaac tcagagagga cagagtttat tcctgtctta gatgaatctg caagacttca 172500 

gagaggcaag ggaaactgct ataagtctta aagaatagta acatcattca ctcttcaatc 172560 

aagcaattat taagccatta ctaaatacca ggtattactt tacacaaata agtaagatac 172620 

agagaagaca cagctttgtc ctttaggagc tcatggtcta gttatagaag agacaggtat 172680 

ataattaaat aattataaca caatagatat aatattaaaa tataacatat gatactgata 172740 

taatttagta tagttactga gagaacccct gactctgcct tcagtctaca gttgtgtgta 172800 

tgtgtgtgtt cgtgtgtatg tttttgtatc tctatgtgta tatgtgtaca gaagggaaat 172860 

ttagaaagtc tttccagagg agacatttga actaagtctt gaggaagggt agaattcagc 172920 

aagcttccct gagaattggg ggcatagttg aaagagggag gtgatatagt ttggctctgt 172980 

gtccccaccc aaatctcatc ttgacttgta ctcccataat tcccacgtgt tgtgggaggg 173040 

accaggtggg agataatata aatcatgggt gcaatttccc ccatactgct ctcctggcag 173100 

tgaataagtc tcataagatc tgatggtttt atcaggggtt tttgctttct catcttcctc 173160 

attttctctt gccgccacca tgtaagaagc acatttcacc tcctgtcatg attctgaggc 173220 

ctcctcagcc atgtagcact gtaaatccaa ttaagcctct ttttcttccc agtctcagat 173280 

atgtctttat cagcagcatg aaaatggact aatacagtaa attggtacca gtagagtgtg 173340 

gtattgctga aaagataccc aaaaatgtgg aagcgacttt ggaactgggt aacaggcaaa 173400 

ggttggaaca gtttgggggg ctcagaagac aggaaaatgt gggaaagttt ggaaccacct 173460 

agagacttga tgaatggctt tgacaaaaat gctgatagtg atatgaatga taaggtcctg 173520 

gctgatgtgg tctcagatgg agatgaggaa cttgttggga accgcagtaa aggtgatcct 173580 

tgttatgttt tagcaaagaa actggtggga tttttcccct gccctagaga tttgtggaac 173640 

tttgaacttg agagagatga ttaaaggtat ctggtggaag aaatttctaa gcagcaaagc 173700 

attcaagaca tgacttgggt gctgtttaaa gcattctgtt ttaaaaggga aacagagcat 173760 

aaaagttcag aaaagttgta gcctgacaat gcagtagaaa agaaaaaccc agtttttgag 173820 

gagaaactca agctggctgc agaaatttgt ataagtagca aggagctgaa tgttaatccc 173880 

caagacaatg gggaaaatgt acccagggca tgtcataggt ctttgtggca gcccctccca 173940 

tcacagacca ggaagcctag gaggaaaaaa cagttttgtg gaccagggtc agggttccca 174000 

tgctgtgggc agcccaggaa cttggtgctc tgcatccaag ctgttccagc cattgctaaa 174060 

aggggccaac atacagcttg gcccatggtt tcagttggtg caagccccaa accttggcag 174120 

cttccacgtg gtgctgagcc tgcaggtgca cagaagtcag gaattgaggt ttgagaacct 174180 

ccacctagat ttcagaggat acatagaaat gcctggatgc ccaggagaaa gtttgctgca 174240 

ggggcaggac cctcatggag agcctttgtt agggcagtgc agaagtgaaa tgtggagtct 174300 

gagcccccac acagagtccc tactggggca ctgccgagtg gagttgtgag aagagggcag 174360 

acgtcctcca gaccccagaa tggtaaagcc actgacagct tggactgtgc acctggaaaa 174420 

gctgcagaca ttcaatgcca gcctgtgaca gcagccagaa ggggggctgt accctgcaaa 174480 

gccacagggg cagagctgcc caagaccatg ggaacccacc tcttgcatca gggtgacctg 174540 

gatgcgagac atagagtcaa aggagatcat tttggagctt taaaatttga ctgccctgct 174600 

gatttcagac ttgcatgggc cctgaaaccc ctttgttttt gctaatttct cccatttgga 174660 

atggctgtat ttacccaata cctatatccc cattgtatct aggaagtaac tagcttgcct 174720 

ttgattttac aggcttgtag gctgaaggtg cttgccttgt cttagatgag actttggact 174780 

gtggactttt gggttaatgc tgaaatgggt taagacttag gggaactgtt gggaaggcat 174840 

gattggtttt gaaatgtgag aacatgagat ttggaggggc caggggagga atgatatggt 174900 

ttggctctgt ccccacccaa atctcatctt taattgtact cccataattc ccgtgttctg 174960 

tgggagggac caggtgagaa aatttgaacc atggggcggt ttccctcatg ctgttctcat 175020 

ggtagtgaat aagtatcatg agatctgatg ggtttatcag tggtttctgc ttttgtacct 175080 

tcctcatttt ctcttgccac tgccatgtaa gaagtgcctt ttgcctccca ttgtgattct 175140 

gaggcccccc tagccatgtg aaactgtaag tccaattaaa cctctttttc ttcccagact 175200 

caggtatgtc tttatcagca gcacataagt ggactaatac aagaggaaaa caaattttct 175260 

caggaaactg gaaagaatgt gagtgtatga gtacagtgta aggagatgga gagtgagacc 175320 

tgggagtggg aattataatg tcaattatga tttagatatg agggagaaga aactaaaact 175380 

caggtaagga caagataata agaggctttg tacaaaacag cagggaattt ttgaggtggt 175440 

tgtggttagc cacagggtga cagccctgcc actggggagt ctgggtcagt aggacggagt 175500 

ctgctttacc catgccccaa cttcagtcac ctcttgttcc cagtcccaca cagctgtgtt 175560 

gcaaatatat gacctcaatt ttaggagcca tgaagccaaa atctattgtt attgtttgaa 175620 

atactttggg aacatgaaat aacactttac ttagtttgga actaagtaag cttcaccttt 175680 

tgatatgaat gtaatttgcc tgttagcttc atcttttgat ataaatgtaa tttaggtctg 175740 

aaaatcaaga gacataaaac agagcaatat aagaggaagc atttctaagc tgataagaga 175800 

tcttatattt tttgagtaat atagttcaga atggtttctt ctaccttgag ttactcagaa 175860 

tagttaattt ccttttttct tgaaacagaa tatttgtcca tatttcattt ccgtttaact 175920 

catttatctc tctcactgca gaggtttccc tacaaatact ttttctccac tggaggcttt 175980 

gggaataaat aaaacattgg agataaattt gcaagttaaa actattgttt atttctccat 176040 

cgttcgtcag taacttaaag ggtaacagag ataagagcta ttccttggga acttctggga 176100 

atttggtagg ggattatctt ttcacctgtt ttccagttca tgaatataaa cactgctcag 176160 

agagacctgt tttagggtaa aagcaatgtt attttgtaca cagagtgctg tgtattacaa 176220 

agtatttgat taaccaggtt gaccagtaac aaagttaatt atttagtcaa tattttacta 176280 

agtgtttcag tcattaccca tttaattttt aagtacttta tttttctatt ctctccatct 176340 

acacatctga tgttttacat gaatgtattt aaattatgaa atcaactgca aaagctagcc 176400 

acaagatttt aagattagcc cagtaaccaa gatgttactg ctgaatgata gacaagaact 176460 

ccacagtttt tacagtttga aggtaaatgg ggaaaaccct tttgaaggtt aatgtcatag 176520 

gaaaagtgcg gaatcaaaac acagctgtat ttattcgtct ttagagctat tttatttcat 176580 

aactttggat tagtcattta aaaatgccac agaagtcata tgttttctat gacagaagat 176640 

aataatacac acaaggtcaa tttacaaaac tctagtttgc agctgtcctg agaaacggag 176700 

ttctgaaaaa tctctgatct ggaggactta gttcaaaata acaagcagaa attttgttta 176760 

agtcaagtgt tagatttggg ttccctagtt cctgggttgt gaatatatgt gtttatatat 176820 

atgtatgtgt gtatatatat agtgtgtgtg tgtgtgtgtg tgtgtgtgta tctgtaaatt 176880 

cctagggtgg aaaaacaggc taatgaagca atgtgaattt ctgaaatttt ctattgtgta 176940 

cttgttttta aattataatt atcagtaatg aatgctaatt gtagcaagtc aaacaataca 177000 

gagcatttga agaaaaatat ttaagtttct ccggtttcca attccttttc ccaagaatag 177060 

aaagtctctt gcgcatatcc ttcgtttttt gttttgtttt gttttcagac ggggtttcat 177120 

tctgtcaccc aggctaaagt gtagtggcac tgtcatggct caatgcagcc tcaatctctc 177180 

aggctcaagt gatcctccaa ccttagtccc ctgagtagct gtgactataa gcacatgcca 177240 

ccatgcctgg ctaatttttt attttttgta tagatggggg tctcactata ttgcccatgc 177300 

tggtctcaaa ctcctgggct gaagtgatct ttcccccttg gctcccaaag agttgggatt 177360 

gtaagcatga gccactttgc ccagcttcct cttcatttct tccccctaac ccactttttt 177420 

tttttgtaat caaaggtatt ttaacctcat taacatgatt tataatttgg aatttctata 177480 

caaggcagta gttttcagcc ctactgatat ctcttacaca catttatgta gacatatata 177540 

taaatatatg tctataaata tatatgtcta taaaaatata tatgtctata aatatatata 177600 

tataaatata tatatatgat gaatggattt cttcattgtt aacagaaatg tttcataatt 177660 

tatttttaaa gccataatct ttaaacagta ctttatttac atagtaccta gtagataaac 177720 

gttgctcagt atttgtggaa tgaaaaatga tatccatcta accattagaa ttagctctag 177780 

cacactccaa ggcacaactt aaaaatcatt agatcagtgt atagggtaaa tacaagaagc 177840 

taaggcactt ggtttagagg tttgggtttt gcatagcccc tctgtgtgtc agttacaatt 177900 

tctattttac ttgatgtatc tggagacaga taacatcatt ggccacttgg ctgtttcata 177960 

ttttcctgtt ctcttctatc cccctgagag tttctccaga gtctccttta tggtaaatga 178020 

cctctgggaa tccagcatag ctctcttctc cttttttact tgatatgctc ttttttgaat 178080 

gatgtcatct acttctgtgg ccttagttac tgatgtgttg atgatattta gatctatatt 178140 

tccagagcct gccattctcc tgagatccag gaaatatttc taaatgtggc tgaacaagct 178200 

catttttatg ttatgtagtt gcttcaaact ctccaatata taatgctatc ctctctatca 178260 

cggtattcca tagctatgct ttctttttta ctgtcttctc tatcttggat aatggcattg 178320 

gttgttcaag ctagaaaatt aaaagtcatc ttaaacaatt gtcacttctc ttacatatca 178380 

tcaactcctg taggttctat ctgtaggttc caaccaaaaa gagtccagga ccagatggat 178440 

tcacagccga attctaccag aggtacaagg aagaactggt accattcctt ctaaaactat 178500 

tccaatcaat agaaaaagag ggaatcctcc ttaactcatt ttatgaggcc agcatcatcc 178560 

tgataccaaa gctgggcaga gacaaaacca aaaaagagaa ttttagacca atatccttga 178620 

tgaacattga tgcaaaaatc cccaataaaa tactggcaaa ctgaatccag aagcacatca 178680 

aaaagcttat ccaccacgat caagtgggct tcatccctga gatgcaagga tggttcaata 178740 

tacacaaatc aataaatgta atccagcata taaacagaac caaagacaaa aaccacatgg 178800 

ttatctcaat agatgcagaa aaggcctttg acaaaattca acaacgcttc atgttaaaaa 178860 

ctctcaataa attaggtatt aatgggatgc atctcaaaat aataagagct atctatgaca 178920 

aacccacagc caatatcata ctgaatgggc aaaagctgga agcattccct ttgaaaactg 178980 

gcacaagaca gggatgccct ctctcaccac tcctattcaa catagtgttg gaagttctgg 179040 

ccaggacaat tagtcaggag aaggaaataa agcgtattca attaggaaaa gaggaagtca 179100 

aattgtccct gtttgcagac gacatcattg tatatctaga aaaccccatt gcctcagccc 179160 

aaaatctcct taagctgata agcaacttca gcaaagtctc aggatacaaa atcaatgtac 179220 

aaaaatcaca agcattctta tacaccaata acagacaaac agagagccaa atcatgagtg 179280 

aactcccatt cacaattgct tcaaagagaa taaaatactt aggaatccaa cttacaaggg 179340 

acgtgaagga cctcttcaag gagaactata aaccactgct caatgaaata aaagaggata 179400 

caaacaaatg aaagaacatt ccatgctcat gggtagcaag aatcaatatc gtgaaaatgg 179460 

ccatactgcc caaggtaatt tatagattca atggcatccc catcaagcta ccaatgactt 179520 

gcttcacaga attggaaaaa actactctta aatagttctt aaatactcca cctcatataa 179580 

tttgtcccta caaccactat gttgggtcag aagctcaaca tctctcacat ggattgtctc 179640 

tcctctacaa tgttgataac aatattttct ttttaaaaca gaaatatgag cattttattt 179700 

cactactaga aaagtatcag tgacatcctt tgcctaattt ggtagtctct gtgtagcccc 179760 

aggggataca ttgtggttca aaaatgcaat attgagattt ctacttacat tcactctttt 179820 

ttagtgcaat atttaatatt cactaaagaa tgtaacatat attttataaa gttcaataat 179880 

gaaatgaatg cctatgaagc cactaccgac ttacatccta gaacattgcc agaactgttt 179940 

catctacctt cacttttacc tctctcttcc tcttgcttcc actaacaaaa ccccacttaa 180000 

gataaatttc atttgttata ctttccttat ttttcatgta tttacaacat atgtatttat 180060 

ttataaatat tatgttgttt agtttgttct tgaacatttg aagatttact cttatttttg 180120 

catgaagctg tggttcatta atttttttgc agaattaaat tttattccat taagtgacta 180180 

catcaaaaat gatttgtcta ctctcttttt gatggacatt agcttcttta taagtttagc 180240 

tattatgtac aatgctacaa tggataatat tgtatatcat cttgttacac ttgtatgatt 180300 

ttcaagaata tatccagcag tgcatttatt gtattacagg atagacaaat gttcaaagta 180360 

taagatatta gtagtgacac atatacatag cttattttaa aatgtattaa agttatatta 180420 

agagtgagtg cgtagctgag catggtggct catgccttta attccagcac cttggtaggc 180480 

tgaggcaggt ggatcaactg aggtcaggag ttcaagacca gactggccag aatggcgaaa 180540 

ctccatctct actaaaaata caaaaattag ccaagcatgg tggcagtcac atgtaatccc 180600 

agttactcgg gaggctgagg aaggagaatc gcttgaatct aagaggtgga ggttgcagtg 180660 

agtggaaatc atgccactgc actccagact gggtgacaga aacaatactt tgcatccttc 180720 

aatccaatca tgttaacact caatattaac catcacaata aggttaggtt aaaacagaca 180780 

gataactgaa ctaggaatta taccagattt gtctcagttc atctttggct agccatattg 180840 

ttacaggaaa gaggacagga ttcagacccc aagagagggt tcttggatct cacgcaagaa 180900 

ataattcagg gtgagttcat ggattaaagt gaaagcaagt ttattaggaa agtaaaggaa 180960 

aaaaagaatg gctactccat agacagagca gccatttaat ttagagcagt ttaatttaag 181020 

agaatgttta gtaagtttct cctgaattcc tacaaaaaga gtacaatagc aatatattcc 181080 

acaagaataa agcaaaagaa gtagaatttt ctcaagtaaa caaaattaga aggctttcca 181140 

tgaatggggc aactgttgga actaagctaa tatgggactg ttagctgatt ctaatgtgcc 181200 

cacaattaga atactcatac agatttttac attacccatc cctcttggtt gttctgacca 181260 

gcagtcagag atcactggtt ggctcacaag aataagcagg gttagcctaa attacagaaa 181320 

cacatttaaa aacaactgat gagactaaaa tttaataaca agtataccat agttcttgga 181380 

acataatttc tctttccagt ctcccatttt tactaaagac aaatcatggt aagattgatt 181440 

tgctttatta tatttggcct gattatttgt ataaagtata gcaagaataa atatttgcca 181500 

taagcttttt aaaaaatggc ttcaatggaa ctctgttcca tagaaaaaat cttagataaa 181560 

taagactttt tttttaagcc aagccctacc atgtgtatcc acactcagat acctacaagt 181620 

tgggtaaatt cctctctttt tgaggtccca agataacttg gggctcctgg gcctgtgatg 181680 

ttctttactt accacaggtc aggaagctca tacagggatg gtgtagtcaa ggtgtgaggc 181740 

cagttcccca agggactttt attggctcta caagtcaaat ttgatttctt aaagaaaagc 181800 

atgccattca ggtaaaagcc ttggtaaaat aaccagtttc tccaattgtg tcccgttgca 181860 

aaagaaaaca gattcttatt gcagtcatgc aaataactat gttgccataa attaagaata 181920 

ttcacagata gtttccaaat tctggataaa actggtagag agaaacaaat atgctccaaa 181980 

ttttgttcat aggagtatac tttactctat tgctacaagc tacaaatagc ttaaaggaaa 182040 

agttttccta actctgaaaa acaaaacaaa ggatcagtaa tgttttaaga aaaatttaaa 182100 

agattacttt agacttctat tagtttagtc catgcagtta acttctgttt aatattcatg 182160 

aacatttcag ctttccaaga gtgttctcaa agatttttct ctattctaac gtaataatct 182220 

ccaaagttat cagaaacctc catttaagaa cacctgttag aattgtacag ttgactataa 182280 

aatcatcttc caaagaggat taaaacagga caaaaattgt ctgtggatga taaaaagtct 182340 

taggacagcc actattaagg ccacaattga tatggaaatt tggtcacttc tgtggcatat 182400 

agcaatttca cataacaatt ataactatta ataacataca ttaagccata tcagaattag 182460 

aggagtttcc cataattttg gaacatatac caataacaca tttatacaaa tagagccaaa 182520 

aaaaaaaacc aagcaccatt ttgtatttgg caatgcttct tgtatgattt ttataccaag 182580 

taagccaaat gtcactgttg tgttagtgca ttattgatgt tacacccaat agacaaatat 182640 

attcaataaa accttataga caaatatatt caatcttaat cagtttgacc ataggtaaga 182700 

ttttaataaa ccttttataa gcctttacaa tttttcttac aggtcagatc ataagcaggt 182760 

ttttgctcta agaaaatctt gttatgcttt tattctaatg ctcaatttac agaaaaaatg 182820 

gaataatacc cctttaactt tagccagtgt gttcacacac agaatttctt ttacaattaa 182880 

tttttcacaa accttccaca acttgcataa cacttcagct ttattctaac ttaaaacaat 182940 

cttttaaccc tttaatctag gcagaaaaat tcatattccc aagacttctt ataatttttt 183000 

tacaaaaaac acattttact ttctttacat cccttgtgta tagaactggt ttttttttag 183060 

tagtctcaga tacatgttat ggtgttaact cttagcaact tttttttttg gtgaaagcct 183120 

tggtaagtaa gggatttttt aattatgtac tagtgtggag cctaggaccc agacagaagt 183180 

gcagataagg gctggctttt tccagcacag ctagtgggca tggctaactc cacatgtccc 183240 

aggccttacc tagctgtaaa gcaaggaaat tgtatagtaa gagccatagt ggcattttat 183300 

gaagcattta ggaggcccat cacctttaaa ttgtacaatg tttcttgcat aaattcgttt 183360 

tcataaattt tttcatgact cacacagacc atctacaaca tgcttggact ttctgacttg 183420 

tcataaacct tcctcttgtt aaacaaccag tcattttgct ttaggacaag aatttaccat 183480 

agaagatcgt ttcttatata aaatctcttt ctttataacc ttctttgcat agctagaagc 183540 

tatgcttatt tcacatgtcc ccaggcatta tctagaatct gatatctcca aggaagatta 183600 

aaatgaacag tttttaaaag ccaaagaagc agtttatgac cttaaagcat ttagcaaact 183660 

taatatctga cctgtataat ttagacctaa tgtttacatt tttgaaaaca ttttaatttt 183720 

accaacaaaa ttgtccttat tttaaaactg tctttatttc ccaaagatta cttaagtcac 183780 

atgaactaaa aggcattaca cattttactt ttctgacaaa atatttgatt tagaacttat 183840 

ttttaagcca atcaatcaaa gctctttcat atataaatat cacacaaata atacatataa 183900 

atacatagac agaagataaa ggaccaattt tccaagccag gaattaaacc ttgaatccgg 183960 

gctgccattg tgatggcaga gaccaagaga aagtactgcc acctggttac aaggtcaagc 184020 

tcccaaggac atacaagaga caagagggaa acttcatcca gttattttta tttttattta 184080 

tttatttttt tttagggacc tgcagcaaag tttataactg accagtttgc tgggccatct 184140 

tgaaaagcag gtttaggggt gtcctaagcc catgttctgt tctgaggtat gccttattat 184200 

gacagaacaa tacagaaaga cccacaaagc acagcagatt tgctacagcc tatgactagc 184260 

ctcacaaatc cttttttcca ttaattaaaa ctttacagag aagataaaca gtgattttta 184320 

ccattcattc gacaggtttg cagagagaga gaaagaaaag cattgcctga ggcaagatgg 184380 

ggaaagcgag gcactcaggg aggccaggaa gacccaccct ttgcagtgac actgaaaagt 184440 

tcgggcggcc acttgtcggt tttctccttt tacattaagt gatatacact tgtgtttctc 184500 

tgagtacata tctacctctg ctactagatt gtaagctcct tgagggggaa gactttccta 184560 

atttttttaa ttgctggtac tcagaatagt atgtacaaca taatagattc ttagcaaagt 184620 

tgctcttttt tactcatttt tcgaaaatca tattgagcac ctattatgct tatttataat 184680 

gtaaatgatg atatgtgtga acaagtataa aggacatgaa ggattttaac agtgatagca 184740 

ctgcatgtat ctaaacatta ccagcttctt gagcagtctt gtctgtaatt agtttatttg 184800 

taagagtaag agttagtctt gtatagaata tgcatagaga caacaacata caacaacata 184860 

caaaaattgt caggattctt gatttcctct ttagtgcttc ttgcccttct tcatttaacc 184920 

acatttcaca gtcactaata aaatatgaac aactgatgtc aaattcagga tcctgtttca 184980 

gaagggaaaa cagaaacatt taccttgttc ttaggacatg ctatgctctt tcacaagtgt 185040 

ctgcccatct tgactagtgt tgttgaaatg gctttcttaa tcaaataatc tcaatctcca 185100 

gctttgtagc tatatctaaa gttcccatat tacctatact ttgggctata gacactgata 185160 

ccatgtgtca acatgcaaac ataatctaga gaggaaacaa agtaaaaacc ttaattaatc 185220 

attaataact ttattcaaat tggtttctga gatttctttt agtaagcaga accctaaaaa 185280 

agtgaaacct tgtcaaaatt atattggaac cctgctcaat cgcagtagga ccttgaagtg 185340 

aagtcctgaa cagctgagtt acacaagggc tagaaatctc tccagttctt catttctcca 185400 

gcctattgaa agggtgccat tttaacaaga aagtaaccac aagtctggaa gggcatgaaa 185460 

gatgagctta gtctggagta gagaatgaat ctccaacctc aagtttcttt agagacactt 185520 

aatttgtttc ttgaacattc atttcacctt gtcactcata ttcttcattt caccttgtca 185580 

cccatattct tctgaaaagt ttgtgacagt ttctacatat atcagacaaa ttgagacaac 185640 

tgtcagcatt aattgggcct caaactcagc cccatgaaat atcagaatca acagagtatt 185700 

tgcaaaagac aagaaaatga ctgtgagcca ggcttgcccc agtaaaaccc agagctcatt 185760 

tataattggc aagatatctt accttaggct agcggaactc aatacttttg gtaagatgtt 185820 

taatgatttc tttacaactg taataactgg gtgctcacct caattctctg taattatttt 185880 

tcttatgaaa gcctagggca atacaaatgg aactctccct gaaactattc tggcttctaa 185940 

tgattttcct ctctactaca cagagtatag aatagtaatt ccattaaata cagattcagt 186000 

aagcaatggc catatcttat attaatcctc ttttatcccc cagttgtagt aaaactcaaa 186060 

gtgaaaaaga gatttttctt cgggagaagc agagattaca aatgcccact taacagactg 186120 

aattttagtc actgtgggtt atcatcacaa tgtttgctac ctgaattgaa ataacattca 186180 

atacatttaa atacatacaa gtagatgtat tagattggtg attaaaatct aaatggagtt 186240 

ttctttaggt aaatatgctt tgtaagatat gctttctatt ctgtattttc tgaccagctg 186300 

tgttcccaga tttctcagct cctctcagct cactggaaag gaaagatatt tcatgatggg 186360 

ttctgagaac tagaaaatat cagggaacag actctttgtg gcataatcca aaacacctcc 186420 

atctaaatat acagagagaa atttcctttt aagaaaggaa agaactggca aaattattac 186480 

tttttcatca tttcaaaact cagggtctat ttggattggg ttagatccca acagactaaa 186540 

ttgctggaca aagttgggtg gtggtttaca tttttagaga aataaattgc aatgggcctg 186600 

gcaggggcag agggataaaa gaaatataga gcccatgctt tacaaatggc ctacttgaac 186660 

agaatgtagt gtcatttcaa ataagcccag gcaggagtcc caggctctgt cattcatggc 186720 

tctacttctt actacaaact ggaacctcta tttgtatctc tgaatacgtg tccaagaaac 186780 

tataactatt tcattgaaat ggatattgca ggcttaatgt aatagcaaat tgtcctaatt 186840 

ctctgcttca tttttcttag gtatttatat accatgtatc tagtatatag ggagagctac 186900 

ctatatatta gcaatcatca tttgcttcaa gaacttcaat agaagtacat cacaaattgg 186960 

aaagctattt gttcatgttc aaaattcaac tgtagaatca acacattggt gctgtcagga 187020 

gctagaggat cacctattct aatgttttct gggttttggt gaggagagta aggcccagat 187080 

tgtgaagagg cttgctcaag atcatacagc aagttagaag gataaccagg tctggatgtg 187140 

agaattctga accctatttt ctgtgactca agtccggaat gatcattgcc ttgattaaga 187200 

tgctctagag aaaaggtaga ttcttgtttg ggaaaaaagt gaacagcttc caaattagat 187260 

tgactttgta ggtagtctcc actttattga ttgtttcctt gactgtgaag aagctttttg 187320 

gtttgatgta atctcatttg tgtatttttt attttgttgc tcgcctgtgc ttttttagat 187380 

cttattcaaa aaaattattg ccctgcccaa tttcatgaag catttctcct gttttcttct 187440 

agtagtttca tatcttcaga ttttacattt aagtatttaa tctatctaga attgattttt 187500 

gtatatggtg gagagataga ggtctagttt cattgttcca catgtggata ttcagttttt 187560 

ccggaacaat ttattgaaca gactatcctt tccccagtat gtcttgtgtt gttggtacct 187620 

ttgttgaaaa tcagttggct gtaaatgcat ggatttattt tgggattctc tattctgttc 187680 

cattggtcta tgtgtggttt tatgccagta ccaagctgtt tagttactat gggagaagca 187740 

tttgcaaact atacacctga cttgcaaact atacacctga caaggcatta atatccagat 187800 

tatataagga actcaaataa ctcaatagca aaagaactca aataattcca tttttaaaat 187860 

tggcaaaaga acgaagtaga tagttattgg aagaaaatcc aaatggctga cagatgtatg 187920 

taaaaatatt caactttact aattatcagg aaattgcaaa ttaaactaca atgagatgtc 187980 

accacactcc agttagaatg gctattatca aaaaggcaaa aaataacaaa tgctggcaga 188040 

gaaaaaagaa ctcttatacg tggttggtgg aaatgtaaat tagtacagcc attatggaaa 188100 

acaatttggg ggttcctcaa aaaaaataaa aatagatcta tcatataatc cagcaatctc 188160 

tttactgggt atatatccaa agaaagtgaa atcagtatgt cagagagaca tgtacactca 188220 

tgtttattgc agtgctattc acaatagcca agatatggaa tcagcataaa tgccattcta 188280 

tggaattgat tgtatacaca cacacacaca cacacacaca cacacacaca cacaaaataa 188340 

aatactattt agccataaaa cagaatgaaa tcctgtcatt tgaagcaaca cagatgaacc 188400 

tgaaggacat tatattaagt gaaattaaac aggcacaaaa agacaaacag cacatgatct 188460 

cttgtatgtg gaatctaaaa aagctgactc tgaaagcaga atctgaaata ctagtaacca 188520 

gagactgagg agagaggggg aaagcggggg ttgcaggggg accaggaaag attggtcaat 188580 

gtgtacaaag ttacaattag acaggaagaa taagttttgg tgttctatta cacagtagag 188640 

tgactctagc aaataacaat gtagtgtata tttcaagata actagaagag agaagatttt 188700 

aaatgttgtc acaaagaaat gataaatgtt tatagtgatg ggtaaggtaa ttaccacaat 188760 

ttgaccgtta tatcatgtat acatgtgttg aaacatcata ttgtatccca taaatatata 188820 

caattacgtg tcaattgtga atttaaaagt catattaata tccaaacaaa ttaagttagc 188880 

tttttaaaaa aaattttcaa cttttacttt agattatata tgcagatttt ttatatgggt 188940 

atattgcaac caggtagtaa gcatagtgcc caataggtag ttttccaacc cacattctcc 189000 

tcctccccca cgcccagttg tctgcagtat ctattgttcc cacatttatg tccgtgtgta 189060 

ctcaatgccc cacttacaag tgagaacata tagtatttgg ttttctgttc ctgtgttaat 189120 

tctcttagga ttgtgacctc aagctgcaaa cagttgctgc aaaggaaatg atttttgttc 189180 

ttttttatgg ctgtgtcgta tcttatggta tatatgtatc acattttctt aatccagtcc 189240 

accactgatg ggcacctagg ttgattctat gtctttgctg ttgtgaatag catggggatg 189300 

aacatatgag tgcatatgtc tttttggtag aatgattatg ttgctttgag tatgtaccca 189360 

gtaatgggat tgctgggtcg aattgtagct gtttaaagtt ctttgagaaa tctcccaact 189420 

gatttccatg gtggttgaac taacttacat tcccactcac agtgtataat tgttcccctt 189480 

ttctctgcag tctcaggagc aactgttgtt ttttgacttt ttaatagcca ttctgactgg 189540 

tgtgagattg tatctcattg tggttttgat ttgcatttat ctgatgatta gtggtggtaa 189600 

gcattttttc atatgtttgt tcgttgcttg tatgtcttct tttgagaagt tctgttcatg 189660 

gtctttactc atttttttaa attgggttat ctgttttttg cttgttgagt taagttcctt 189720 

atagattctg aatattagac cttagttaga tgtacagttt gcaaatattt tctcccattt 189780 

tctagttgtc tgtttactca gttgatagtt tgttttgctg catagaaact ttagtttaat 189840 

taggtctcac ttgtcagttt ttgttttcgt tgcaattgct tctggggatt tagccaaaaa 189900 

ttttttgcca aggccaattc tgagaaacag acacatagac caatgaaaca gaaaactcag 189960 

aaaaaaagct gcacatctac aatcatctaa tctctgacaa gaaaaacaag cagtggggaa 190020 

aggacaccct attcagaaaa tggttttgag atagctttaa attttggttg aaattggcca 190080 

aatggacaat tatatttgag acacttaatg actgctaaca catttgggaa ttcctcaaca 190140 

gtcaagtaaa gtttattgtg actttaagat tgttatccaa ttggcagaag acagtcaggc 190200 

tctccaaact atctaaacag acaacaatct gacttcaaat tcagtgacct taaccagtat 190260 

gctctgtttg caacctcgtc tcttctttct cagttgtttc atcatcatca ttttcatttt 190320 

catgatcttt tttaaggtct ttgtgattct tagccagtat ctttcctttc caaactctcc 190380 

atgcattaat gtgttcattc attcatttat tcaataggca tagataattt aacacattcc 190440 

atgaaagaga tatataagac aactctcctc agaattcata gcctagtgag ggggacattg 190500 

attgtaacag aaaatgacaa tttaaaaaaa tctaagtttg aagctcacat accaatggca 190560 

ataatctatg cagttcttga tttttttcta ataaagcaga ttacaatgta cttttatgta 190620 

aatgctcctc atgccaagct tatgagatga tagaataaaa agaagtccca aagaggttaa 190680 

agcaaggtca gtaagtccca ggaactgtat gtgtcctgtt taccacttgt gacttgtacc 190740 

tagcataggt tcccggcata tacttggcac ttaataaatt tttgactgaa tgactgaaca 190800 

cagctaataa atgtctaaac taggccttaa acacaggtct cctaatcttg attccagtat 190860 

ttattcaatt gcatccattt tctgtgcccc ctgtgatcat taccttactt tactcctcag 190920 

agccacctct ctcattttct tcaagtccca tctacttgat ataaatcatc ccagttaact 190980 

aatgattggg aagctattat tcaatatatt aacaaactta aaaacagtct cagctgaagc 191040 

agaggatgat tgattctcta ggtattgcac ctcagttgag tagataattt ggatcaggag 191100 

gcccatcaaa tcctatcaga gatataatca catattgctc ttttgtagaa tcccagcctt 191160 

gggagtcctg tgacaagttt tatgagaaga gtaaggggtc tgagatgtga attttttaat 191220 

gacaaacagc tataaatttg tttttgaaat gcttatattt ttattattaa atggttgaaa 191280 

ttatgaaaat agttatgatg atgtcattga tagcaggaat gaggttgata attataagaa 191340 

aatatgacaa ccatttactg agatccaact ctgttccagc aatgtgccaa atgatttaca 191400 

catgttatct caatcaaatc ctagcaattt catgactaga tatcaactgc agtttatagg 191460 

taacagaggc acaatggctt ccattaactc cgaatattca acaaacacaa ctcatccttc 191520 

acatgattca tccccaaaca gatgtactgt tcttgtttcc ttatagccac attcatccat 191580 

ttccctcaca cacacataat attagaatac agatattatg tatattatat gtactatata 191640 

tgtatactat atatacttat atatgctata agaaaggcca aactggcagt caagtaaaca 191700 

aaatattgaa gaccatagaa tactttccaa ctcattctat aaagctggct tctataaagc 191760 

tggcattact ctgataccaa aactcaaaaa agacgttaca agagtgcaaa ctacataaca 191820 

ttatctttca tgaagataga cacaaacatt tttgttaaat tagttaacca aatccaataa 191880 

tatatataaa gcataacaaa tcatgactga gtggagttat cccagaaaaa taaggttgtt 191940 

taacattcaa aaatcaaggt acttcatcat attaacagac tcaagaagaa aaaccacata 192000 

atttttgaat acatgaagaa aaaacatcga aaaaaaatct atatttattc ctgataaaat 192060 

ctctcggcaa actgggaatt aaagggaact tctttttcct aataaaaggc ttgaataata 192120 

ttctgtggct taatatcata cacaatggta aaaagctgaa tgtgttcttc tcaagactga 192180 

gaatgaggca aagctgtctc cttcagtctg catttactgg agattccagt caggataatg 192240 

aggcaagaat aagaaataaa aggaatacag atcaggcatt taaaaacgaa ctttctattc 192300 

acagacaact tcatcatcta tgtaaaaagt cctcaagaat ttttaaaaac ctgctagaac 192360 

taaccagtca acgtagcaag gctgtagaat acatggttaa aatttacaag tcaatttcat 192420 

ttctgtatac tagcaatgaa ctactaaaaa tttagattta gaggacaata ccatttataa 192480 

tagcatcaaa aatatgaaat attaatagga ataaatttcg taaaagattc acaaaaaaat 192540 

ggtacactga aagctacaaa acattgctga gaaacattta aaggaggcct aaataagtgg 192600 

agacatatac tgtgttcaca aaatgaaaaa ttaaatattg ctaagatgga aatcctctca 192660 

aaacttatct ataattcaag gcaatttaaa acaaaatccc agcaggcatt ttctataagc 192720 

tgattataaa attcataaga aaatgtcaaa aagctagagt agccaagata atttttcgaa 192780 

aaagaggcca aattgaagga cttatactac ttgactccaa aatttattat aaagctaaag 192840 

ttaaataaaa agcattgtaa tactgatata aagatagaca tatagatcaa tgaaactgaa 192900 

taggaattaa gaaatagtct cacatttata tggtcaactg attttcaata aaagtgccaa 192960 

agcaattcaa tggtgaaaga tcatctcttt aacaaagatg ctggaacata aatctataaa 193020 

ggctagaaaa taaaaacaaa aacatgacaa aatagaaggg tttttgcatg tttcagactg 193080 

agtgtaagta gtacagggct tatatgttgg ttccatgatg ttgaggacgt ggcctttttc 193140 

aatcttgcag ctctgaaatt ctgtacatgt acctttcatt ttgagattta aaatagtggt 193200 

tccaacccct tctgttatgt gtatatgata gtcagtagga aagaaagaaa agcaatgaaa 193260 

aacaaactct ttaatttaac ataaactgga cattgaacac atcacttctg ttatcatccc 193320 

actgaactga gccataacaa atataaacat atatgaaatt tcacttgaac cagttcaata 193380 

aatgagctgt tgattatgtt acagtttttt tcaaagatca tagaccagaa acattctcta 193440 

ttttgctttt catatgtaag atgggaagag ttaggcttta gattgaggag aaaatgaatg 193500 

gtatcctaga tcctgcaatc agagttcaaa gctgtgtaga ctttgagaag atgggaaaat 193560 

ttcacataat tttgtaacat tttgtaatga tgttatctac ttaagaacac cgagttacca 193620 

taacttcgag ttctttgatc catggccatg caggtccacc aatatttcta tgagtcagca 193680 

caaaatgctt agatctcaat gaaacatgag agtaattttt gatgtcatta tcagctattt 193740 

tctggggagt gatttttttc tttgatcata atggtgaata tttgggatca cgaaagtaca 193800 

aaaaatttta caggtctgca acaaaatgtg gatctctttt tctccctgaa atttttaata 193860 

aaagatgaag gcaatgtgct gaaagtgaaa aatgattata aacatttatc atctggggca 193920 

ttttgttcat tgtggagttc aaaacaaaca aataaaattt ttatttcgag ttacgttgta 193980 

acacgatttc ctctgagttt ttcagtctca tgaaatctaa ccttgtctaa gcttttaata 194040 

gaattggcta aaaaccttca ttttataagt tcctatcttc ctagttcccc tcctcttaaa 194100 

aaaatgtcgt cactttctgc catcctacat tttttgtctt ctcccacttt tttccctgtc 194160 

ttcagagaac tcacactttc tgagtacttt taatttaaag gttaatactt gccattttta 194220 

gagggacaag atcagtatga acagacaaaa aacctatcta taactgtcac ctgggtacta 194280 

ccagatttct aaaacttggg gagaaaacat ttctttaaga aaatgtgttc tgttgttccc 194340 

gtaagaatat ttgatcttat caaaacatgt gctccagttt ttggattgga aaacaaaaat 194400 

gtcactgtaa ctgtgggggg agacatttca tgcattagta tgactgagta caaaaaaaag 194460 

tctgacagtg aggtatgaag aaaagggtct ccaatctagt atgtttgctt gtctctctgc 194520 

gggtctacca gtgtgatact ttgttcagat taagcacttt tggttctcaa tctagaatga 194580 

taaatttgac acccataaca tcattcatgt gtatgtgtgg tatttgttat ggttaattag 194640 

aatttttttt ttttttttaa atggagtctc gctctgtcgc ccaggctgga gtgcagtggc 194700 

gcaatctcag cttactgcaa cctctgcctc ccgggttcaa gcgattctcc tccctcagcc 194760 

tcctgagtag ctgggattac aggcacacca ccatgcctgg ataatttttg tattttttag 194820 

tagagatggg gtttcaccat gttggtcagg ctggtctcaa attcctgacc tcgtgatccg 194880 

cctgcctcgg cctcccaaag tgctgggatt acaggcgtga gccatggccc cggccggtta 194940 

attagaattt tacaaccaga acgtggctca ttgacatttt ttctaaccaa tgctcgctta 195000 

atttgtttct tctgttttgt aaatgttgcc tctttgcaag cgtcttcagc agaaaggatg 195060 

gttgagataa ttttttaaca taaagttagg ttgaacagtt tttagatcat tgtgtttccc 195120 

taggcaaaat taatattctg aattttttaa ggtattcatt caaagctaca gtcagtggct 195180 

catacctgta atcccagtca cttgggagac tgaggtgaga gaatcacttg agaccagata 195240 

tttgaggctg cagtgagcca tcatcatgcc actgcactcc agtctggatg actgacagag 195300 

tgagactcca tttctagaaa aataaaataa aataaaaaat aaagtcacaa acaccatcag 195360 

ccatggttca ccaacctggg tgtaattggt ggaccagaga ttatggcaca tatgttgagg 195420 

ttgacagatt ccaccactgt caggcagcct tgtggcttta ggcagaaact gggtgtcact 195480 

tggggttttg cttcagagaa agccaatgag atcattttga gtgtggggtt ttcttttgga 195540 

gtaaaactgt agaccttcat tttcctagag aagtactttc cgttcactgt tttcagttcc 195600 

ttatgatatc attaaggttg tgatcatgtt gcagttgcta tttgtcagca cttattagca 195660 

atagtaacat gcaatgatta ctgagtgcct gctaatccca agcaatgtat tatagtaact 195720 

gctttgcatg aattatctca attgatcctt acattaattt tatgaaggtt gtattcttat 195780 

gtgttttaca gatgaataca ttgaacccat agtgggtaag tgattaagta agcatttcaa 195840 

atcagttctt tctgattctt aaccctctga ggtgagcgag agtgaagaaa gctaatactc 195900 

tttataggaa gccttcttga aacatttttc ttttcctttc ttgtaatatc ccatgtggca 195960 

cacgtggcct tcaaagatat tataaagact ctgcagaaaa atattttttc aagtaactat 196020 

tgacaggcct gggtatttca cttcagttgg gagacactgt atctacaaat tatcttatct 196080 

caaccttcct agcctcattt cctgcccact ccacacaaca aactgtacag ttacccaaca 196140 

tcttgtgaac tctaacactt gaggagcttc aaaaatactg ctgctgggag agatcttctg 196200 

catttactca cacagtatgt ccttttatgg ggccttctga gactcttcca ggaagaatga 196260 

attactcctt ccatgtaaat tcatatatag cttgattaca caatattttt catatggctt 196320 

tttgaaagag taatatatac ttacattaac acaataaaaa atggctttca gtgtaaagta 196380 

tgtctccctc tcatgcttaa agcacaggct tctcttaagg gaacaactat tacctgtgat 196440 

ggttaacacg cacagaaata aacacgtaca catagctctc tgggctttgc aagattggaa 196500 

gcctgtgtaa tttggtgttt tgcaccttgc atttttcact taatatcttg gacttctttc 196560 

tatattagta cataagcttt atttatagta gctctaaata ttttattata tgacatccca 196620 

taatttatgt aaccatcctc ctattgacat ttggattgtt tccagctgta ataaacaatg 196680 

cagaaataag catcctcatt tgcatgctta tacagagagt gagtggatgg gccttgaaag 196740 

cagatttcca ggttttgaat cctagctctg cactactagc tcctatactc ttaagctggt 196800 

caacctctgt atgcctcact tttctcttat gtaaaaatgg atatgtaatt gtaattgcat 196860 

agggctttct gagtattaag ggagatatga catgaaaaag agctttaatg cctagtatat 196920 

agtaaggact taatgatgtt ttactactat tgttacaaag atcatgcctt tgggggcatt 196980 

tgtgagtatg acttcaggat aaattcctgg aagtggaaat cttggggcaa aagacatgtg 197040 

catttactat tcttatagac ccctggctta attgggttca cattgaagca gatcttgaga 197100 

caaggatctg aatacaaata ggttatttag atggtggagg aaagtccaac aggggaatgg 197160 

gaaagtgaaa caggaaggga aaatagccaa taatgggtgc attattgagt cagttatcac 197220 

ttagtgtact tggagctcaa tcctactgag gaaactctgg gagccagtac agatgcaagc 197280 

atcagagtta tcctgctcca ggggagaagg agctgaggta tcagtacacc gcctcctgtc 197340 

ctggtgggtc agtcattggc tgagagctgc tcctaagagc agtggcatcc agattagagc 197400 

actgggaaat ctctgcctca ggttctggca ataatgggat tgtgtagatg attttaaaag 197460 

agcagaaaaa ttgaccaaaa aatcattcag atgcttattg tcatgatacg ctgggaattc 197520 

tctacaatct ttgttataaa ataattgtct cctcggggac accttgcctc tatgtattcc 197580 

acaccctggg aggtactcat ttccaacact ttcggcctat tgcacaagca gacaaagtgg 197640 

gtataattaa tcagaggatg aaaggaatgc aagtgccgac tattggaagc ctgtcttgca 197700 

tgaactgaag ggagagacaa tatggtcaga gaatcaacag tgaacctgct ccactcacac 197760 

tgtctacaca agctgatggc ctgatggatg tacttcttga agctctgccc gcagtagtga 197820 

gaatttcccc tcactactct ctttcctggc caccgctggg tggagctgtg ttgcccaagc 197880 

agtccgcttt cagctcacat gaaatattga gccacccatc tctgaaacag acctgggttt 197940 

ttaatcccct gacagctggt tatgggaact ctctgtgagc tctcaggtgt gaactgaggg 198000 

agacacattg gtttaacaag ttaagtaata tgtgggactt agctgccaat ttgtgtaatt 198060 

tagttgctcc cccggacatg ctcatgcctg atcgcaaaag taccattcat ttcatgatgt 198120 

gttactgatg tgcctgccca aactactgac ttggaagatc tgacagtaaa gagctcatga 198180 

tgagcaaccc agtcacacaa ttacttgatg tgccatgagc aggctcaatt tccactagtc 198240 

cagtagcata ccaaaagctg ctttttgaat ggcaaatggt tctttgaagg cttctggctt 198300 

tcgcatcatg tcctgattga tagtagagct tgtccattct ttttctctgt tacctatgac 198360 

actaacagct accagctgat gccactgtcc ttgtaattct cattatcccc taatctctaa 198420 

tattctgaag atattgcata agctagtgta tgcccttcat cctgtaaccc aacccatttc 198480 

agactaagga atgaagatga aaatgctagt ttggaccctg aaatgccttg caatgtagag 198540 

gtgattttcc atagctaaaa cagaaacaac agcaaaagct gttaccatat tgttaccaat 198600 

atttgaactt ttctaccatt tggtgagtga catttggtca ttataggcac ctcacattta 198660 

gtgaactgat gtcttgtgac tctaatctaa tacaacttgc taagacagga aacacttggc 198720 

acttccctga ggcactgatt aatgaggaaa cacttggttt tacagttaat ctgaattatg 198780 

caacccctgg gaacctatta attttatgag aagatagctt tatatgatga ttgcatttgt 198840 

taacatctgc attcataatg caaaagctac atttgtatat gaacttacct caaattaaga 198900 

aaatgcaatt tggagccaat ttgtggaaat gcatgtatat gtcaaatgct aactctctcc 198960 

ctctcccttc tttccttttg tctttccaat ggcttctaga tatgaacaga atggggaaaa 199020 

ccaaactaac ttgaacttac tatcccactt ttatacatat ttaattcaat ccttacaaca 199080 

gcattatgag tcaagtatta ttattcctat tttaaagtaa tttgcccaag atcacacaat 199140 

ttacaacata caaattataa aattactata tggaatttat gcctagatca attgatgcca 199200 

gagctcattt tttccactcc tgcaggagtt ctcaaaaact ggctgcagtt atatgactga 199260 

tttgggatgc tttttaaaaa taatgatgct tgaggcctac tcctagagat tctgatttaa 199320 

taattctgtg gtagaatgta ggcatccatg actttttcaa gttccccagg tgatactaat 199380 

atactgttac atctgtacca ctcttctgca ccatttccct ttactctcat aattataatt 199440 

cacattttgc attgtcctta cagttttcaa agttttgaaa aaatacatag ctcattgtat 199500 

tagtctgctt tcacgctgct gataaacacc taactgagac tgggaaattt acaaaagaaa 199560 

gaggcttaat ggaactcaca gttccacatg gctgcggagg cctcagaatc atggtggaag 199620 

gcaaggagga gcaagtgaca tcttacatcg atggtggcag gcaaagagag agcttgtaca 199680 

gggaacttct atttttaaac ccatcagatc ctatgagatt catccactat catgagaaca 199740 

gcacaggaaa gagccacccc cataattcaa tcacctccca ccaggttctt cccatgacat 199800 

gtggcaattg tgagagttac agttcaagat gagatttgag tggggacaca gtcaaatcat 199860 

gtcattccac tcctggcccc tcccaaatct cttgttctca catttcaaaa ccaatcatgc 199920 

cttcccaaca gtcccccaaa gtcttaactc atttcagcat taactgaaaa gtccacagtc 199980 

caatgtctca tctgagacaa tgagataatg atcctatgag gctgtaaaat caaaagcaag 200040 

ttagttgctt cctagataca atgagggtac aggcgttggg tagatacagc cactcccaat 200100 

gaaacaaatt ggccaaacaa agaggttaca ggccccatac aagtccgaaa tccagcaggg 200160 

cagtcaaatc ttaaagctcc aaagtgatat cctttgactc catgtctcac attcaggtct 200220 

ctgtgatgca aggggtgggt tcccatagac ttgggcagct ttgcccctgt ggatctgcag 200280 

ggtacagcct ccctcccagc tgctttcatg ggctggtgtt gagtgtctga ggcttttcca 200340 

ggtgcatggt gcaggctgtc agtggagtta tttttctggg gtgtggagga tggtggtcat 200400 

cttcttacag ctccactagg cagtgtccca gtagggacac tgtgtgggtg ctctgacccc 200460 

acgtttccct tctgcactgc agaaggttgt ccatgaatgc cccacccctg cagcaaactt 200520 

ctgcctgggc atccaggtgt ttccatacat cttctgaaat ctaggcagag gttcacaaac 200580 

cccaattctt gacctctgtg cactcccaga ctcaacacca tgtggaagct gctaaggctt 200640 

ggagcttgta ccctctgaaa ccacagcctg agctccatgt tagccctttt aagccacaac 200700 

tggagcagct gagacacagg gcaccaagtc cctaggttgc acacagcaca gggaccttag 200760 

gcccaaccca ggaaaccatg ttttcctcct aggcctccag gcctgtgatg agaggggctg 200820 

ctgtgaagac ctctgagatg ctttggagac attttcccca tcatgttggg gattaacatt 200880 

cactcctcac tacttataca aatttctgca gccaacttga atttctcctc agaaaatggg 200940 

attttctttt ctactgtatt gtcaggctgc aacttttctg aacttttatg ctctgcttcc 201000 

cttacaaaac tgaatgcctt taacagcacc caagtcacat cttgaatgct ttgctgctta 201060 

gaaatttctt ccaccagata ccctaaatca tcctcctcaa gttcaaagtt ccacaaatct 201120 

ctagggcagg ggaaaaatgt agccagtctc tttgctaaaa cataacaaga gtcacatttg 201180 

ctccagttcc caaaaagttc ctcatctcca tctgagacca cctcagcctg gactttatcg 201240 

ttcatatcac tatcagtgtt tttctcaaag ccatttaaca agtctctagg aagttccaca 201300 

ctattccaca ttttctgtct tcttcagagc cctccaaact gttccaacct ctccacctgt 201360 

tacccagttg caaagtcact tccacatttt caggtatctt ttcagcaact ctactggtac 201420 

caattactgt attagtctgt tttcacacta ctgataaaga catactgctg ataaagacat 201480 

agagactggg aaatttacaa aataaagaga tttaattggt ctcacagttc catgtggctg 201540 

gggaggcctc agaatcatgg cagaaggcaa ggaggagcaa gtcacatctt acattgatgg 201600 

cgggcaggca aagagagcat gtgttcaggg aaactccagt tttaaaacca tcagatctca 201660 

tgagactcat tcactatcac aggaacaatg aaggaaagat ccaccctcat aattcaatca 201720 

cctcccactg ggttctttcc acaacacatg ggaattgtgg gagttacaat tcaagatgag 201780 

ttttggctgg gaacacagca aaaccacatc actcatctaa tctttaaacc aaccgaggga 201840 

agaattttta tgctcatttt acagaagaga aaactgagat tcaaggagtt tgaaatctta 201900 

cccagtatta caagagtaag tagctgaaac ccaggataat tggaaaaggg ctgtttttat 201960 

ccttatttag aataccgtaa ttgtgatccc ttttggttcc ctctctcttt ttccctcctc 202020 

ctctggttta ttccccagtc tgggcctgca aaagactctt ggatgccatt taaagctgtc 202080 

aaccatgtat gagtgggaaa agtggtagct ctgaggactg attcattacc aaagaagcat 202140 

gggttcgtag tgaaaacagg gagatagaga tagaagtttg aattaactta agaaggtgat 202200 

tttatttctt tgaagcccag tttcctcaac aataaatgga aaaagaaacc ataatagcta 202260 

cctattgttt tgtcatgaga ataaaataaa attatctgta caaagatttg taaatcgaaa 202320 

ggcattatat ctatgttagt cattactatc tcacttataa tgattagttt tgaggtgtta 202380 

tgttgctttt ccagggctgt tgtaataaat taccataact ttgatgactt aaaactaccc 202440 

aaaactattt tcttccagtt ctggagacca gaagcctaaa attaaggtga cagtgggggt 202500 

cacatccctt ctgaaggctc tagaagagaa ttcattcctt gcctcttcca gcttctgttg 202560 

gctgttggca ttccttggtg ttccttggct tgtagtcaca ttacttcaat ctctgccttc 202620 

gtcttcccaa caccttcccc tctgtgtctg tctcaaatct cctgctgctt tctttatgag 202680 

ggcacttgtt actggatttt ggacccagct gaataatcct agatgatctt ttcatctcaa 202740 

gatcttaact attatatatg caaagtttct ttttccaaat aagctaactt ttacaggttc 202800 

tgggaattag gacatgaggc atatcttttg gggggccagc attcaacccg ctacaggtat 202860 

tatgagtgtt tctcttttct taggctcaat atccccctct ctgattcact aactgccact 202920 

tgctagtgga tttcagttcc aaatctttga tttggtaaat aagttgtcca gtacataagt 202980 

cagctctgcc tcctgcccta accaactaca cagaactttc tggtgttttc tgaatatccg 203040 

ttgtactttc ctaccctgtg caattccttt gatgcctttc ctctctttct ggaactcaac 203100 

actgttttcc accctcttct gtgaagtatt tctaatcatt aagaaagact gctctctctt 203160 

ttctctccaa atctgttaga tttttgggct ttctgtcttg attccagcac ttatcacagt 203220 

gtgaccttta ctgttgtagc tgagcacctg tctgcttctc catgaaactg agtgttgttt 203280 

ttctcatgtc ttcaagatac agatagtgac tcattcatct ttataccacc tactgcctat 203340 

ggccagttgc cagacatgtg gtaccttttc agcagaggtt ggtgaacctc atggaaccgt 203400 

gtagaactgc atggcacctg acaacctcct ccctcaggtt tacctggtct actaccctgt 203460 

ggaggcagct gaaataaaag ctgtagagtc ttattgcctt ttcagtggtg taaattctac 203520 

tgataacttt gtcttattct ccctatttgg acatttcttt attattatta ttgtggtggc 203580 

agtaattatt gttattttta aaaattgact tataggtatc ttttcttcct tttttaagga 203640 

aggttttctt ctgtgaaaat atattttttt cgggtggaga gtctatacct tcactgtcag 203700 

taataactga tatttcggat atcatcttac tttgcttaac tcttggttga ggtaggcgaa 203760 

ggtacagaga agctgtttga gtctctattc tctcctcaaa tctctgccct gagctttgat 203820 

ttaggctgat atttttgaag tttaataaac tggtttttct ctttactttc ccgtatcctt 203880 

tttgtagtga aatccttact ccatcttatg tttaaaatcc aaaactatgt ttgggataaa 203940 

gtaaacagaa gattgaattt tgtctcattt tctaaacatt accaatgctg tatgtggtag 204000 

gtacacagtt gccttcatga tttttcaaaa gcttttcctt ttgaagcgaa cacctgtctc 204060 

agaatctcct agattaaata gttatactca catattcctt aaactgtaaa ttctttgaag 204120 

gtaggtactg cctttgctct tcacaataat catggtgcca gtgcagcatc tggcacataa 204180 

ttggtattcc aaaaaggtgg ataaatcagt taatacaaat aactattctg ggagttggca 204240 

caacatcaat tgacaatgga ttcctctgat ttcttatttc tactataata caacttaatt 204300 

tcgtggtagt atgttaatgg acataatctc tctttttacc aacacaatat ccagggaagc 204360 

ccaaataaac tcttggttga aaccaacata tttcacaatt cctgttcttc atatccaacc 204420 

tccacataac agctgatgat gacatgttgt cttacagctc ctttagtccc actctgcgaa 204480 

tttagggaca gcttagattt gtgagcattt gcggaacaag acagaagcct gccccactcc 204540 

aaaagcagtt aactttagtc cacatacaac agtgtcccaa gtttcaggcc taccacttaa 204600 

acctctaaac tcagaatgag atctctgggg atcagccagg agactaaggg gttttctctt 204660 

cctgtttttc ctatgggctt ggacatcagt cttaccacat acggcatggt ttctcccagg 204720 

agaagtccat ttgaacctca ctaaacaata atttctgggc catacccttg cagtatgtct 204780 

aagacactcc tatctgtttc ctcctactgg tccatcatac atacttgcaa taaataatca 204840 

aatagcagga caatcaagtc ccgaccctca ctgctttgta acttgggctt ggagaggttt 204900 

atccaagata aattggttca tgcattatga tcacctccca gggcatgtgt gacattcttc 204960 

atagagtaca ctaagttctg tataatgggg gtgctctaca gaaggctgtg ctttcctctc 205020 

tcattcctct tctgccttca aaatgaaata tagagctgaa aggccatacc tgtcttaatg 205080 

acgtgccaag ctgcatacat tacattttgt atctcacctt ggacaagaaa gaaataggat 205140 

ctttaaagaa atgctcaaca cactgtgttt acaacctctt tccgctctaa attcatcatt 205200 

tgtatattaa tataactatg atataaaatt gccaacaaaa gagatataaa agcatactga 205260 

aatagtctct aggagttcaa tctacatttc ccatcactca gagccagaag cactcaatca 205320 

tttgttcctg catgtaaaag aggctgacac tcagaatgag aatacaaagc agctgtcctt 205380 

caaggtccag ccctattgta tacatagtaa gaacacccct tccccccaac tccaacaacc 205440 

tgaccactga cagagtagga aacacggtca tgataggagc tgggggcttt gcagtcaccc 205500 

agcaaagaaa taggggcagt cgtctttaag ataataaatt aaagttaaat catttagtaa 205560 

aataagacaa aaataaagat aaaagtaaag gcaatctgaa acaagctttg tatcaaaaca 205620 

acaacaacaa catgctgaag aaaataagga agaaaattgg tagctttagg ttttttagtt 205680 

caagcttgca cctctgtggg aaaggctagt gtcactgaag tgtggctgag gtgttttcag 205740 

aatccttata actcacaggt tgcttctgac atattcaaaa ttcctaccat tacagtcatt 205800 

gcatccagaa agtctagtga agtattgaag agtctaatac tgagtcattg aaggatatag 205860 

tacaattaca ccctatgaca attggtgtga acttttatct attttctctc ctaatctctt 205920 

caccaggctt tttatttgct tatctccctt agttccagta cttaggattt ttatgggggt 205980 

tattgtaaca aacttacaaa ctgatttctg tttctactct agtcccctgc aacttaccct 206040 

tcacacaact actagcataa aacccaaata tagtttgttc cctccctaaa actcttgaaa 206100 

agctccttaa gagtaaaatc ctgcagagta aaatccaagc agaagcataa aagcaccata 206160 

taatctggct catgccgatt tcctctaacc cctcactctc tcagaactcc ttgcaattgc 206220 

ttcaaaacac attagtgatt catgcttcta tgtcttctct catgagattt cctgttagcc 206280 

tgggatactc ttctcctctt ctaaggctga tcaattttca ttcatgcttt gagactcagt 206340 

ctgggtgcca tttcctttgg gaagccttct ccttttcctg gagtgaatta tatatatgca 206400 

ccacaagtta ccatagtgtt tttttctccc tccaacacta ctccttacat tgtatcacaa 206460 

ctgtatgtgt aattgtctct attccccact agacagtaaa cagtaggaaa tcatggactg 206520 

aatctccagc acccagtaac ataatgctag gaacagaaca gatgtttaat aaacattcct 206580 

ctaatgaatt cacaagctgt tcctgagaca gattctacct ggagcatttt ggcatatatt 206640 

atgcctttta atctttcagc aacaaatcca atcctttcct tttatatgag aatagtccat 206700 

ttcttggagc attcttcaag catcaggcta aggtaggtga gtattattac accaggcaat 206760 

tgaaggaaag agaggatgct cagatgggag gtgagtgatg aaagaggcaa tagttaagaa 206820 

agaggaacat aaaacagaga tcttaagaca ttacaacttt gatgttataa gaaaattgta 206880 

tctccttttt tgagatttta gagggaaaaa ggaacatgag attatatcac tgtatattat 206940 

taactaggta atatgttcac tattttatat gcttttatgc attaacttac ttaagcctca 207000 

aaaaactcca gaatataaat actattatta ccctcatttc acagaggaga aaactgagga 207060 

acagagaaag aactaacttt tccaaggtac atagctagta agtggcccag tgatgattat 207120 

cagcctgagc agtctgaaac caagagactg tgctcatgac cactacacta tgttctttct 207180 

gcatgatgca gttacagtgc agaggggtaa atattttaac aagttgtagc agcagcactg 207240 

atggaagact ggtggtcaag gaaggcattc gagaggagat gaggaataat gaagtcttag 207300 

aggagcagga attaaccaaa gggcagggag tatatgagca ttttaggaag aaggagtgat 207360 

gtctgtagag atgagcaggc tgtggagaag aatctaccac cttgatctgg agttgtagtt 207420 

atggctgaat accaaagaaa aggggaaagg agaaaaacag gaagaccaag atggacatca 207480 

gtgtgtgttg ctcaagttca tactcagtag aattggcctg ggttgcccag cagggatgta 207540 

ggagaagtcc ttcttgataa gaccacagtt cccctcacat gaggatgctg ggcaacaagg 207600 

ctcaaatgga caattcccag agccagcaaa ggactgggat gcataggaga cactaaatac 207660 

acactattaa ggtaaaaaat atccatagag accttctttc caattaccca ctccccaacc 207720 

ctcacttttt tttttaaatc agtgaggacc acatgttcaa atacattaag tgatatgttc 207780 

aaatagatta agtagtatag ctccttggca gaaaggttgg gactagaaac aaggaaatgc 207840 

agcctttttc tttgaagaac tgatgatatt ttagggagat acaaatcaaa caaaaacatg 207900 

ttgaagtcaa taacagcaca gcatctcaat aaatgcaaaa caaacaaaca aacttatttc 207960 

acaatttaag ttctaggtgc tgaagggttg actgagtaaa ggtggaaacc aggaaacatt 208020 

cctggagcag gtgagctttt aaccaggttt ttgtgaagtg atggaccttg gctggaggca 208080 

aagaggactg gaagaaatga gctcctgaag gggagacatg tcttatgata ctatgatata 208140 

tgccagtttg gtgggttgta ccggcaggca gcttgataga atggaaacag cagacacgtg 208200 

ggagtcataa agaactgagg tcaagttgct gacattcatc agctacagga ccatcagctg 208260 

tggttcaatt atttgatccc atgtgttctc ctctattcaa cgagggtaga ggttctcatc 208320 

acttagtggt tattgtagtt acagagtcat ttggtgacag cagggattga tatccttaga 208380 

actcctcttt tttactattc attgaatgaa ttcacaaatg aataaatgag tgaatggatt 208440 

gccggttaga ttttcttcaa gctaaagaac acttcaaccc cttcaagcaa tggaaatgtg 208500 

acaccagtgc attctagcat aatcagataa aacatacctc actgtcccta acctcctctt 208560 

atgtagcttg cctgggagga caaaggaaag gggaacgggg tctcaagatc gctgagtggt 208620 

gggctgtttg ataatacaaa tataaaaagg aagaggcatt ccacagacct caggcactta 208680 

tccctaagct tctgagaaac accgttcctc atcggatcca tgggtggagg cacatctaac 208740 

ttacttttac atcctataca aggagtgcct agagttttac tcctactcaa actacaggga 208800 

aagaaatcca gcgtccgcat ttagagtatc aagccatatt gtgggatatt ttctgaggtt 208860 

tgggtctgaa acacctaaat gttgtgcttg tttgtactct gctatgtcaa ggagagtctg 208920 

aaaagctcca gtcctggagg aacactaacg cctagtcaaa aaattagaaa agagctgttg 208980 

cagtgtaaaa tatcataaaa tcttagggtt ggatgggacc ttgcagccac ccctgataag 209040 

ggttttcaga ctctgtgatt ttaagaacta gtagaatttc aaaaagcaaa acaaataaaa 209100 

acaaaaataa gaatttgacc taagaaggct gtattagctt cctagggctg ctgtaacaat 209160 

ttaccacaag ctgggaggct gaatggaaat ttactgtctc acagctccag aggctgtaag 209220 

tttgagatca aggagtcagc atggctggtc tctactgagg actgggaggg ataatctgtt 209280 

ccaatgcttc tcttagcttc tggtagtttt ctggcattcc taggcatttc ttgacctgta 209340 

gatggcatta tccctgtgtg ttcacatcat cttcctcttt gtatacatct gtctctgtgt 209400 

ccaaatttcc cccctttgat aaggacacca gtcttgaatt aaggcccacc ctaatgtcct 209460 

cctcgaaact tgatcatttg caaaaccact atttccaaat aaggccacat tcatagatac 209520 

tacggattag gacttcaata tctgttgtgg ggacacaagt taactcttaa cagtagccaa 209580 

ctagtaattt aattaagtaa ggacatttga aaaaaagaga aaatacatgc atcctactat 209640 

cttcatcatt ttgaagaaaa gagattttaa ctcctaaaat tttaggaatg ttatcatttc 209700 

actgcaaagg gcagtctttc ccagaaagag tagctggaat cttacaccag acaacatgca 209760 

catatgcact gcagcactct tcttcctaat cttactccag gttgtcagag acattgccac 209820 

caaccactag ggatctgtga aaaagtttta tttggttctc ctggtctagt acaactgttt 209880 

gtccactgct taaacctctt ttgcaaccac cttagcctga gctttgaaac tatagttctt 209940 

acatgtgata acagacacaa tcaaaacaag agcttatgct gttaccttaa catcacactt 210000 

ctgtacctaa aattatgtca gaccaaattc ctttcctgtt ctctgaaatt tcttcagcaa 210060 

gtatgctatg ggttgtttct gtgaaacaga aacttgtttt tgtgaaatct cacatcaggg 210120 

actgagccag gcattctaaa gcatctttat ttatttttat tttttgcagc atctggagtc 210180 

tgaatttcag ctctgtgtct gttcacttgg tttacaaagt gatgctgatt taatcagctc 210240 

ttacactgga ttttatgtaa atgattttgt agttgtatac catgaaaagt aaccactatt 210300 

caaaggcaat gagtaatcat aggcagccac ttaaattttg ggactacttt tcttttattt 210360 

gtagccaaag acaagtttcc tcaagctggc agaatactaa ccacatgaag cttggattgt 210420 

ttgagttgct attcatgacc agcaactgac tttgccttat aaatgtccag agatcctgat 210480 

acacaaagag tgtggactat cacttgtcaa atattttgag aaaataagaa aagaatgagt 210540 

aaaaattgtg gcttaaatat tatttgtaat ttctcctatt tgtcatttct tttgttaaat 210600 

gctatgctct tgctcctggt gctgggggga actcagtatt gagatgtcaa taatcaattg 210660 

aaatcaataa tcaattgaga gtcatttggt gacagcaggg attgatatcc ttagaactcc 210720 

attatatttg aatcatcaaa cagcccacca ctcagtgaga tgtcaagaga aaacctttga 210780 

gagaaaacta agggaatgct aagaaagtca tgctgtaggt gaagagattg gattttggtg 210840 

tcagatatag gtggtttaac cccccaactt tgccattcag ctttgtgtga tttcaggcac 210900 

aatacttaaa ctccctgggt attagtttta tctcctatac aatggaatta acgtctactc 210960 

cttaagactg ttataaggat tcacatacct ctactggaga tagggtggga tgagtgggga 211020 

gaggactttc aagaagcaaa cagtaaacta aatatacttt tgcctaaagg tgaggcttga 211080 

tcaaattcca caggaattgt tatccataat agcacttcat taaaaatatt ctaattttct 211140 

tccaggagtt caataattat gtaacatact ttttgggaaa aaaaatgagt ttgcctccag 211200 

caagagtaga agaaaaccaa atacgcttca taccagacaa ccaaagtgtt ctgaaatata 211260 

ataaactatc caaggtcatg tagaaaacta ggcattcaat gtagttttct ggcagacttg 211320 

caggctcaaa atgctatttg gtaaacagag ttaaaatgat gattgtcaca aaacttcata 211380 

agaaaacaaa tttatcaggc actctttttt tttttttttt ttttttttga gatggagttt 211440 

tgttcttgtt tcccagactg gagtgcaatg gcatgatctc ggctcactgc aacctccgcc 211500 

caccaggttc aagtgattct cctgcctcag cctcccaagt agctgggatt acaggtgccc 211560 

accaccacgc ccggctaatt ttttgtattt ttagtagaga tgtagtttca ccacgttggc 211620 

caggctggtc tagaaatcct gaatttaggt gatccaccca ccttggcctc ccaaagagct 211680 

gggattactg gcgtgagcca ccatgtccca cctatcaggc actttaaaag attatttttc 211740 

attctgacca aaaccaaatt gtggttctta acatttaata attattttgt aataaggctg 211800 

ttatgtgtag attaaatttt ttattttatt tttaataaat attgttggat ttaagaaaat 211860 

gttgaatggg gtatggagga tatagaagat gtaattaaaa tatcaaggaa gcaacaaaca 211920 

aatgaatttt ctctgttgct cttattccta gcagcaatag actttggaac atttgcatac 211980 

gttcatcttg gcagtagttt tcaaaggaat tttttcctga cttattttaa cactttgtgt 212040 

aataaaatcc tataaattcg cagaaaagtc ctgactattc agggaagagt tcttactcat 212100 

gtaaaaggca tttcacattt ctgcatgaac actgacatat gaacttaaaa gctagaattt 212160 

aacttaaaca atggtttgtc tgtgctcttg tcacctagtt ggataaggca gatgctgggg 212220 

aaagtcctgg tgatgtagcc tcctcagctc ctcaggaatc acaaggaaag acatgcagaa 212280 

aaaagaccct actaccattc ccaggacatt ggccttgtcc tgatgtcttt ctccacgcca 212340 

cagtcctata gctgaaacaa gaggcggtgt cctgtgggag gaggcagcag gctgttctag 212400 

aattaaatct aagcattggc acttagctgc atgactttag gcaagtgtct cagactcttt 212460 

aagcatcagc ttctcatctg taccatggag ataccagtat ctaccccaca tggattatta 212520 

gaaaattagg ctagatggta caaggtgcct ggcacataat gggtaaatta tcagcttcta 212580 

acctcaaacc acacagttat ggcatattgc atgaggagaa tgaggatctg agaaaagctg 212640 

gtaaactaga ttccatttgt tccttgttta gttctagttt gtactcaata gtaaggaaac 212700 

gttttttttt tagttggaca ttgtttctgc tttccaagag gcaatcacct actcacagaa 212760 

agcacataga tcagatatta tttaatatgt attacaggat ctgctgtaga tgcagtatta 212820 

ttttacgtgc taggaagata tgaaggtgaa gtaagaaatg ttcctactct tttttttctt 212880 

tctttttttt tttttttttt gaggagtctt gctctgtcac ccaggctgga gtgcagtggc 212940 

acaatcttgg ctcactgcaa cttctgcctc ctgggttcaa gcaattctcc tgcctcagcc 213000 

tcctgagtag ctgggactac aggcatggcc caccacaccc agctaatttt tgtattttta 213060 

gtagagacgg ggtttcacca tgttggccag gctggtctca aactcctgac ctcaaatgat 213120 

ccacccacct cagcctccca aagtgctggg attacaggtg tgagccacct cctaaggagg 213180 

ttacaatatg tagaggaaga agacagggga tgaggatatg ttactccttg aatagctagt 213240 

acaatctatc tatgaacact ataagcacac tttcattcct aacagttttt ctgtatatgc 213300 

ttctcatttg acactagtca tacctggtgc cagctgtgtt aaatacatgt caacagatgg 213360 

cagtcaccat ttactattca ttctgtgcca agcactgtgc tgagcacttt gaacacctta 213420 

tcttgtttaa accttagaag gaacatgtga ggtagggtta tcgtcaacat tttacatgcg 213480 

gaaactcaag ctcagagagg ttaatgaata tgccccaaag caacagctca taagtgatag 213540 

aattgggttt gaaatgcagg tctgtcttcc tccaaagctt tctttccccc tgaaactcca 213600 

tattttacaa cctcacctct gtgtattttt cacaagaggt tacatagtag gtgctccaaa 213660 

gtatttattc ctagataatt ataaagaggt aagtagctgg tctaggaagc cctttcaaca 213720 

ttaactcagc cctgttgtgg atttcccctt tcagctgagt gagatttcat agtaaagatt 213780 

ttgtttccgt ataacattac tacctctaag tgcaatttca aaggtctttt cctaagactc 213840 

atggcacatg tctctcatac atggttttcc atattatata aagcatttat taggaccttt 213900 

taaggtctcc atcaatgatc ttaaattggc agaattttgt aatccttcct tccttagctt 213960 

atgactaaga ttacaagaaa gtccatgcta tttttataat tgttgttaga gaagaagaat 214020 

gctatgcaag cctgcaagct ctaaaacaag cagactgtat caagaacaca gctcctgccc 214080 

tggagggtat ctgatctaaa accacaaatg ggtgtattat atgacactga ccatttccat 214140 

acccttgggg cagcagtaaa gatcatttga tgtcctccta ttttaaaaat ggacaaattt 214200 

ttcttttttt ttttcttaag atagactttt accaattata gtgaaagagg ggaagaatag 214260 

aatagcaaga actgagaaac agagcagtgc taggagtgtt gagcctttaa agttcattga 214320 

aatgtttcta gctgcttcat taatatccaa ctgtaggtct gaggatggca tctgtagttt 214380 

gtgagtgggt gtgtttacac caaatgggaa ttcaggaaat gcattccaaa atcaaataga 214440 

aataacttgg aaattattgt gtctttattt tttcattaaa caatccttaa ttgagtgcct 214500 

gtgtgatgac tgatagtccc tgctgctgga agctcatggt ctaaggccag agacaacaaa 214560 

ggcactgctg gttgacacag aatggggtga gttttatgac agtggaattg aaggttatag 214620 

ttgaaatcca aaggagtgcc acttaataca gccaggtagt gagtgattta ggaaaaccca 214680 

gcctggagaa gctgaagctg agttttgcac gttgagtaaa agcaactgca ctcaagaatc 214740 

aggttccaga gaggacagca tgtcaatagg tatgaagaaa gtaagagggc ttattatgtt 214800 

taaggtactt aaggaacaaa acaaacaaaa attcctataa atatataact gggttctcct 214860 

gcaggtaact ctagagataa aaccagaggg aaaaaccata gccatatctt gaaggacttt 214920 

ttatgccagc cttaggagtt tggactttgt cctaagaaga gtgattaaaa gatttttaat 214980 

ataaacatga taaaaaccaa tttcccttat agcaccatga aggataggtc agggagggct 215040 

gtgtgtgaga acaggctgtt acagtaagaa aacatggtgt ctgtggagat aaatatttaa 215100 

gtgctaaaac tgataagaca aagtaactgg ttaggataag gttagacgaa ccatgcagct 215160 

gagtggatga ttgtgccgtt taccaagata acatacacaa gaaagaattt ggaaggggtg 215220 

atacttaaag tagattgtag cataagttaa tggaccagta ttttgtatta tagttgtttt 215280 

gatgtccact tttttttcta tcatcctcca ccagtttaca gaggttagaa gatagatttg 215340 

ggggtcattt caaatttcac atcacttatt ggctttctga tcttaagagg atcacttaat 215400 

tctataagcc tcagtgtttt cagtggtaaa atgataagaa tacttatggt acaggggtgt 215460 

cagaaataag ggttaaaaga gaaaatgata tagagtcctg aaacaaaata agtgttgtta 215520 

aataaatggc agttgttatt attacttttg ttgctgtctg ttgaatgctc actgagtgga 215580 

gggtctatgc ttccttcact ctgtgtttct gcaggacctt gtctagtggt ctgtgtataa 215640 

aagactaagc cgtaatcatt gaattgagct gaattgaagt ggtacaacat ggaaatgcca 215700 

aatgaagttt ctgaaagaca tgaagtgttt atgcatgttt aatgtacttc agttaaataa 215760 

gtcactcaga aagggtcaag agtaacattt ggagatgaag gacaggaaaa gagcaatgat 215820 

attaattaag caagatcgga agtggctcct aacagcaaaa aaaaaaaaag taaactgtcc 215880 

caagggaaga agcctaagaa caagtcctca cagacatgtg gggctttcaa gagaagtcag 215940 

tgatctgatg gttctcctca gctcaaggtt ttacctagat gtcatatcag caattatcta 216000 

acatattgac cactgcaaga agaaaactat agatcataag ccatatgaaa agaattaaac 216060 

actagcctag tgtagaaacc taatctgaac attgatgtat tgtccaattg tcatcatgat 216120 

tcttatttta tttttctttt ggtcatttaa ttttctctga atgtgagcca tggtaatatt 216180 

tatatgtaat tttaggttgc ctttgcattt tatactaaat ttgtccaaca gagaaatcaa 216240 

aattatattt atcattaaca taaaataaat aaaacataag ccaacaaaaa cagagaacaa 216300 

tctttttttt tttttttttt tttgagatgg agtctcgctc tgtcgcccag gctggagtgc 216360 

agtggcgtga tctcggctca ctgcaagctc tgcctcctgg gttcatgcca ttctcctgcc 216420 

tcagcctccc gagtagctgg gactacaggc acccgccacc acgcctggct aattttttgt 216480 

atttttagta gagacggggt ttcaccgtgt tagccaggat ggtcttgatc tcctgaactc 216540 

gtgatccacc cacctcggcc tcccaacaga gcacaatctt aagtggaaat ccgattgagg 216600 

tactggtgct gatttagatt tgaggggtta atttgcctgt cgctaaagag caagttagca 216660 

tatatctagg catagtaggt aaatctaagc caatggggca tgaaaaggga ggaaatattt 216720 

aacaccacat aaattcagct gttcttacgt gctttctttt ctaaaaaacc tactacactc 216780 

ctgctgtgca ctatggccca ccctatctca gggctgctgc aaattgttat gcacattatt 216840 

cataccacga gggtgccagg cagaggagag ggaaggcgaa tcccaaagaa acaggcatct 216900 

ttttctaatt tgcacaaatc tatggctaaa caacagcaca actacatctt atgccccaca 216960 

gtcttttcca tcagaaaaaa aaaatcccca aattcacaaa ccaaagccta gtttcttagc 217020 

acagattgtg ctttttttca catctcggat gaatttaaaa gcctgagatg ggaggcagaa 217080 

cagggagaaa gcaggttaaa ggaaacatag ttgctgttat gtaggataaa taagtctaga 217140 

gatctaaatt atagcatggg gactatggtt aatgatattg tgtactggaa atttgctaag 217200 

acagatttta tgggctctta acaaacacac acacacaaag gtaactatgt gaaatgatag 217260 

atacattaat ttgcttgaat gtagtaatta ttttactatg caaatgtgta tcaaaacatc 217320 

atgttgtata acttaaatat atgcaatttt taaaatacct gggaggctga aaaaaatagg 217380 

atctacatag atacattttg atgttcctga acttccctaa ccctctcttt aattgtctcc 217440 

agaagcctat tatttatcct tttaaatggt ggtttttcag agtctttgga tctgcccgaa 217500 

ttcataaaag gccatcactt tgatgcccct tcacgattgt gaggtgccta ttgcaacaca 217560 

accatgactg ctacgtctgc taagagggct ttttgagtct gttctctgct cctggaaact 217620 

cagcttggag aaaagccagg agaaagcttg ctagtgtaca tggtactctt atgctgattt 217680 

tcaaatagtc aactcccaca gctttgcatg ctttaacacc aaaatgaaag acagaaacag 217740 

tgttattgct tcattgcttt ctggtcagga acaaacacat atgaagctgc ctttacccat 217800 

acctattttg agttactcag aaagatctaa atagaatctt atatccaaac ataatggaag 217860 

aaagaaaata tgtttctact ctttgctctt gtttacatag tggtctgcag tttgggtctt 217920 

aatatgagtt ttggaatatt atgaaacagc ataaccaccc agctagaaca taatagctaa 217980 

tataaatcag ccagctcaca agcaaaacag atttttaaaa tctgctttat attctctaat 218040 

gcaccacaga gaaaatagca agaatttgaa atttatatac agagaaaaat tatttagaga 218100 

ctttgttgaa aaataagtat atataggagc aataaacaaa tctatcatat tagaacctag 218160 

aattgcacta aaaggaagca gatttcagtt atttcccatg ccataaaaaa aatatcaaaa 218220 

actatagatt tagaaacctg agccttcctc attccaccaa aaatggggga ggcaggaatg 218280 

ttaccaacag gacaaattac acacatttgg gttgaaagaa gagaaagaac tgtaataagc 218340 

ataaccagca acatgcagaa aatcagcaga agagcttgga gatcaaagca gaccataacc 218400 

taaagctaaa gcctttaaca gactatacca agtcatgcat gaaaagtgcc aggaaggaat 218460 

gtatttacta aattatccac ttagtcccct tgagatagca gtattctgta gaatttcaat 218520 

ggaaatgcaa caagatccaa agtgttatta gagtccatat aaatgtcctt tcccctctca 218580 

gctgttctca agccctcacc attagtactt tgaggggctc gtaaccccac tcagtaagct 218640 

ttttcttcat gcccaaagga aaaattatag acttctcttc caagacttct agatgtttca 218700 

ttattgatcc caaactattt ccctggtttc atcttcagga ccctccttct cacatcccct 218760 

atgttgcaac ttattctgtc tctagtgtta acttattctt ccttctaagc agtgaggaga 218820 

agtatttaag aactgggtca atggggtcaa acaaaccttg atccaaggac cagctctgcc 218880 

atataccaaa agtatgacct tggcaagtca cttcattcat tcattcatga attcaaccat 218940 

atttattgag catccagtgt gtgccaggat ctgtgcttag ccctggagat aaagaacagt 219000 

acaaaaattc ctgtcctcat gagacgctta ttctagttag gggagacaga aaatgtctaa 219060 

taattgccat gatgaaaact aaagcagagt aaagatgcag agagtgatgt gggagtgaag 219120 

agaagagaga gaggaaagtg gttgtgcttt cgacagattg atcaaggaag gcttttctga 219180 

taagatgaca tttagatgga aacctgaatg aatgagaaag tgagccttgt ggtatctggg 219240 

agatagtgtc ccaggcagag ggatgatgag tttgtggtct gatgatttca gtctcttctt 219300 

taggaactac tctccattgg tattgtatcc ctgttttggt cagtttggga agctataaca 219360 

agataccaca gactaggtgg cttaaacaac agaaatttgt ttctcacagt tctggaggcc 219420 

ggcaagttca ggatcagggt gccagcagat tcggtgtctg gtgagtgccc tctttttggt 219480 

ttgcacatgt cagtcttctc attgtatcct caaatggtgg agaaaacaga gaagggaagc 219540 

aagctctctc ttgtctcttc ttaaaagggc attaatccca ttatgtgggt ctcaccttca 219600 

tgacccagtt atctcccaaa gctctatctc caaatgtcag cacactgggg attagggttt 219660 

caacatatga atttggtggg taggtatggg ggagacaaat atgcagtctt tagcaatctc 219720 

tgatcacatg aagttgttgt gaggatcata tgaggtttat tagtataaaa gtacttaggg 219780 

tcattcctga agcataagaa atggtcacaa aaggacagta ttattttttc tatcaggttc 219840 

agcaagaata tcccctttga aagctccttt gccatatgct tcctcccatc ctcattgccg 219900 

gcattattcc tctctccatt tggtttgcat tgcatgttgt acacaactgt aatagcattt 219960 

atcatattgt atatctttat tcttttattt tccctttttt ttgtttcctc agctagactg 220020 

tgagcttggt gaagggagtg actgcacctt attcttgggc cctcagagcc tagcacagtg 220080 

cctgacacat taaagtttct aaattcatcc ttgctgaatg aatgaatgag cttaaatact 220140 

tcttgttcca tgaagttttt aaacttattc tcatctctat ctccacttat attttgtatc 220200 

agtcatatta cataatatat gtaccactta acccatattg ttttgtatgc aaaatttttt 220260 

gcatctatat cttgtttcca actagatcat aaagtcttat ggaacagaaa tggtatatta 220320 

tattctttgt atctttctta gagtgttatg tacatacatg ggttaattat cattgtactg 220380 

ttaaaagaaa agcttaatga ataaatgcac agatggactt aaaaaccatt tgatggagta 220440 

taacacattt tttatggatg gagtgagtaa tgatgttaga atataactac tattgcttca 220500 

gagcaaccac agagaacctc agaagtccaa ctcagagaag ctttagaatg ctctcagaat 220560 

gaagtggaac aataaacatc tcaatattat ttcaaaactc aaaaacttat tcctggtcac 220620 

taaaagaagt aaaaagagtc taattcttta gaaacagaca aattttggct cttgcatttt 220680 

caggaaaatg atcttggaat agttagacaa agtgccaaaa atttacagaa ttcagtggga 220740 

tgtgatttta acatctagaa gagttgtgtc ccaaataaag gaagcataca acaaatatag 220800 

aggattcccc tcatgttcct atttacaata atctaggaac gtgatggagt tcctttacat 220860 

agaaagacac ctaaatatct cagccagaaa atgatgcaaa attctatagc agactgtata 220920 

gggtttccaa tctctgtaag tgaacagaat tacacatgta tacactgaat ttaagggaca 220980 

cacatgataa gaccacccca gttagagagt gtattaattt tctattgctt cctaacaaat 221040 

caccataaat ttagtgattt aaagcaacac agttttacta tctcacaatt tctgtgcatg 221100 

aatctgggta tgcattagct tggtcttcag ctcagggtct cactaggctg aaatcaaagt 221160 

gtcagcctag gctgtggtct catttgaggc ttgagatcat cttctaaggt cagcaggaaa 221220 

gtggtgatgc tgctgctgct cttgctcctg cttatctctt ttaaggtttt gccagattaa 221280 

atcaaaccca cccaggaact tttccttttc aattaactca aaatcagttg actaggaaac 221340 

ttaattgcat ctggaaaata cctttggcaa tataatgtaa cataatcatg ggagttatta 221400 

cccatgatat tcccagcttc tgctcacact caaggggaga tgattataca gcatgtgtat 221460 

accagggggt ggatatcttg gaggctatca gaattttgtc taattcagag ggcactgaga 221520 

cagataaata agaatcaggg tgtcccacac aacagcatta cacataagtg tctcagaatt 221580 

acttaggatg gtaaaattac tgaggatgat ataattgtgt tctgatcctt ttttgtttgt 221640 

ttgtttgttt tgagatggag tcttgctctc tcacccagac tggagtgcag tggagtgatt 221700 

tccgctcact gcaaccttca cctcctccac tcactgcaat cttcgcctcc tgggttcaag 221760 

tgattctcct gcctcagcct cccaagtagc tggaattgca ggcatgcgcc acaagcctgg 221820 

ctaatttttg catttttagt agagatgagg tttcaccatg tttgccaggc tggtcttgaa 221880 

cacctgacct caagtaaccc acccaccttg gcctcccaaa gagctgggat tacaggcatg 221940 

agccaacgtg cctggccatg ttctgatcgt ttaatgatag caacatttag tattatagag 222000 

catgaaaatg tcaaagtcgc aactctaaaa tgtttttatt tagaaatatg tgcctattag 222060 

aattttagtt actagaatta tttaagaaaa ttggacgttt tataataaca ggtcaacatt 222120 

gtaattccaa gctaaaatgg gtgagtaatt gctttaggct tgtaatttca gattaaaatc 222180 

ttacttgtaa catttaagag aacttcaggt tcatcatacc tataaattta atttattagg 222240 

cttataagag tgacttaagt tcttgggaag tttcttaagt cacctaattg gtatacttca 222300 

aaagaaaaca gaaatatgtt acattaataa atgtgcttaa atatttaagg aatttaatta 222360 

agttgtgaaa tcttccttca aagtaattat aaaatttgct atgtttatga atgtgttaat 222420 

aagatttata aactaaccta aaagcttaag aagaacaaga gtttaaataa attgaatact 222480 

aattttgtac caaaattacg ttaaataggt ttttttctag gcataaaaac tgccctcagg 222540 

aacataaaaa tactcatgtt caacaagttt caactgtgct attttgtatg acctctgtca 222600 

agttacttaa cttctcttag cttcagtttc ctcacctaca aaatgggtat catcatatta 222660 

acttttaggg ttgctgtaag gattgagata ttttgcataa agttgttgga acatgtaagg 222720 

ccctcaataa tgtcagctca aagaaaaaga gattagaggg tccaagatga tagactagaa 222780 

gcagctcacg tgtgctgctc tcagaaagga aacaaaaggg ctagtgaaca ctgaccctgc 222840 

aggccaaaca tctgagaaac cacattggga tccatcaagg cagcagggga cacagagcag 222900 

agagaagcaa agctggacac cagcctatct tggcttagtg tgaaaccagg agaacctctc 222960 

ccacatggta aagggtgagc gagtgagagc cccctagaag attcgcactc tccacaggga 223020 

cctatgcaag actgggaatg gaaaaatccc tctggccccc cacgctccca tctgtgataa 223080 

taaactgagg tagagagcca cctggtcatt ttgtggaggc aacttttgag tccaagaggg 223140 

cctctgcaag cctttggccc caaagcagac cagcactgtc accatagctc caatagaggc 223200 

cacatttgca gtgtctggga gaaataagat tgatctatcc tcatttcatt ggacagggct 223260 

cactaccagc ttccagccca gtggtgctgc ttctgcctga acttggccag cagccatagc 223320 

ctcctgctgt cccaggaagc acccagatgg cagaacaagt gatctcaccc atccccacca 223380 

ctgataacca ggtggacaat gcctgttaga gcttccagcc gaacagtccc acttctacat 223440 

aaactcagcc aagagtgcag cattctgttg tcctgagaaa tacccagatg gtagggtggg 223500 

tgacaccaca cacccatgcc aatggtagcc aagggggaca atgcctgcta gatcttcaag 223560 

cccagaaaac cctcttctgc ctgaactcag ctagcaggca aagcctgcct ttttcctgag 223620 

aaacactgag atggcaagaa gggtgaccct accaacccct accactggaa gccaagtggg 223680 

taatgcttgc cagagtttcc aattcacagg ttccacctct gtctaaattt gttggaggtg 223740 

cagcttcctg ttgccctgga aacacccaga tggcagggtg ggcaattcca cctacccctg 223800 

cctctcatag caagatgggc cacatctgct agagcttcca gctcagtggt tctgcttttg 223860 

cctaaactct gtagacaggt gcaaccttat gtttccctga gaagcactca aacaacatat 223920 

tagggccaac ccagcaagga aatggcttgt ctgctaactg caacctctgc ctaaggaagt 223980 

cctgtggacc agaacaccca acaaaagaaa cacagtcatg gagacagtaa ttggaggggt 224040 

ctcctccaag acccaggagc agactataat tgaagccagt tgtctaatcc cactgagaat 224100 

cacaatcaaa ccctcaaggg caccaaaaaa gataaaagca aaaagcccat ccaaaggact 224160 

gcaacttcaa aggctgaaga aacatgagcc cacattgatg agacaaaaac agtgcaggaa 224220 

ctctggcaac aacaacaaca acaaaaaagg caaaaatgtc ttcttacctc caaatgacca 224280 

cactagttcc ccagcaaagg ttgttaacct ggctgcaatg accaaaatgt cagaactagc 224340 

attcagaata cggatagaaa tgaagatcat tgatattcag gataaagttg aatcctaatc 224400 

catggaatct aaagaatgta ataaaacaat acaggagatg aaagataaaa tggccatttt 224460 

aagaaagaat caaactgaac taacagaggt gaaaaactca ctttaagaat ttcataatac 224520 

aaccagtatt aacagctcca tcaaccaagc tgaggaaaga atctcagagc ttgagagatt 224580 

gcttctctga aataactccg tcagacaaaa ataaagcaaa aacaataaag aatggataaa 224640 

acctctgaga aatatgggat tatgtaaaga gaccaagaga ccaaatctat aattcattgg 224700 

catcccaagg aaagggagag aaagcaagca acttggaaaa catatttgag gttatgatcc 224760 

ataaaaattt tcccaatctc actagagagg ccaacattta aatccaggaa atgcagagaa 224820 

cccctacaag acactatata agacaaccat ccccaagaca catagtcgtc agattctcca 224880 

acgttgaaat gcaggaaaaa atgttaaagg cagctagaga gaaggggaag gtcacctaca 224940 

aagggaaccc tatcaagcta acagtggaac tttcagcaga aactctacaa gccagaagag 225000 

acttaggggc ctatattcac cattcttttt tttttttttc tttttttttt gacagagtct 225060 

tgctctttca ctcaggctgg agtgaagtgg cacaatctca gctcactgca acctccgcct 225120 

cctgggttca aaagattctc ctgcatcagc ctcctgaata gctgggatta caggtgcccg 225180 

ccatcatgcc tggctaattt ttttattttt agtagagatg gggtttcacc atgttggcca 225240 

ggctggtctc gaactcctga cctcaggtga ttcacccacc tcggcctcct aaagtgctag 225300 

ggttacaggc ctgagctgcc tcgcccagcc tcagcattct taaaaaaaaa aaaaagaaaa 225360 

aagaaattcc aaccaagaat ttcatatcca gccaaactag tttcataagc aaaggagaaa 225420 

taatatcatt ttcagacaag caaatgctaa gggaatttgt tactgccttg cacagtcatt 225480 

aagggagtgc taaatatgga aaggaaagac tgttaccagc caccacaaaa gcacacttga 225540 

gcatataggt cgttgacact ataaagcaac cacacaatca agtctgcata ataaccagct 225600 

aacaatatga ttacaggata aaacctacac atatcaattt tttttttttg agagggaatc 225660 

tcactgtcac caggctgaag tgcagtggta caatcttggc tcacttcaac ttctgcctcc 225720 

caggttcaag tattctcctg cctcagcctc ccaagtagct gggactgcag gtacgcacca 225780 

ccacgcccag ctaattttta tatttttagt agagacaagg ttccaccatg ttggccagga 225840 

tggtctcaat ctcttgacct catgatccac ccactcggcc tcccaaagtg ctgggattgc 225900 

aagtgtgagc tactgcacct ggccacacat atcaatatca accttaaatg caaacagaat 225960 

aaatacctca attaaaaggc acagagtgac aaggtgaaga agaaagcaag atccaactgt 226020 

atgctgtctt caagagatcc atctcacaga caatgacacc catagattca aagtaaagga 226080 

acagagaaaa atttaccaag caaatggaaa acagaaaata gcaggggtaa ctattttaat 226140 

ttcagacaaa atagacacta aaccaataat gatcaaaaaa gaaagaggga ggctagacgt 226200 

tgtggctcac ccctataatc ccagcacttt aggaggccaa ggtgggatga tcattagagt 226260 

ttgggagttc gaccatcagc ctggccaaca tgggaaaact ccatctctac taaaaataca 226320 

aaaattagcc agatgctgtg gctcacactt gtaatcccag ctactcagga agctgaggca 226380 

caagaatagc ttgaacctgg gaggcagagg ttgcagtgag ctgagaccat gccactgcac 226440 

tccagcctgg gtgacagagt gagactctgt ctcaaaacaa aacaaacaaa aaacaaaaag 226500 

aaggacagaa gggcattaca taattacaaa gagttcaatc caacaagaag accttactat 226560 

cctacatata tatccaccca acacaggtgc acccaaattc ataaagcaaa tacttacaga 226620 

cctatgaaga gatttagata accacacaac aatactagga gattttaaca ctccatgacc 226680 

atattaacca tatcattgag gcaaaaatac taacaaagat attcaagatg tggacacaac 226740 

atttgaccaa atggactgaa cagacatcta cagaacacta taccccaaaa cagaatatac 226800 

atttttccta tctgcacata gcacatactc taaaatcaac cactcaatag gacataaagc 226860 

aattctcagc aaaccaaaaa acaaacagaa atcataccaa ctacattcac ggactacagc 226920 

acaataaaaa tataaatcaa tactaagaaa atcactcaaa acaatacaat tgtatggaaa 226980 

ttaaacaacc tgcttctgaa tgacttttgt gtaaataatg aaaggaaggc agagatgaag 227040 

aaattctttt aaagtaataa gaaaaaagat acaatatacc agaatctctg ggacatagct 227100 

aaggaagtgt taagggggaa gtttatggca ttaaacgctc atataaaaat gttagaaaga 227160 

actcatatta ataactacca tcacaattag agaaactaga gaaacaagag caaaccaacc 227220 

ccaaagccag caaaggacaa gaaataacca aaattagagc aaaatgaaag gaaattgaga 227280 

tgcaaaataa aatacacaaa agatcaatga ctccaggagt tggtcttttg aaaaaattat 227340 

taagacagac catgagctag actaataaag aaaaaaggaa agaagattca aataaacaca 227400 

atcagaaatg accaggggta ctttaccact gatcccacgg aaacacaaaa acacctcaaa 227460 

gattatgatg aacacctcta tgcatacaaa ctagaaaatc tagaagaaat ggatgaattc 227520 

ctggaaatat ataacctccc aagattgaac taggaagaaa ctgaatccct gaacagacca 227580 

ataacatgtt tggaaattga atcagtaata aaaagcctac caaccagaag aagcccagaa 227640 

ccagacggat tcacagccga attctaccag acttacaaac ctatgacatc cataggtttg 227700 

taatgaagaa ctggtaccaa ttctattgaa ctattccaaa aaactgaggg ggagggactc 227760 

ctccctaact cattctatga ggccaacatg atcctaatac caaaacctgg cagacacaca 227820 

acaaaaaaag aaaacttcag gccagtgtcc ttgatgaaca tagataaaaa atcttcaatg 227880 

aaatactagc aaaccaaatc cagcagcaca acaaaaccta atccactatg atgtagtagg 227940 

ctttatccct gggatgcaag gttagttaaa catacacaaa ttaaaacgtg atttaccaca 228000 

taaacagagc taaaaccaaa aataacatga tcatcttaat aggtacaaaa aagctctcca 228060 

ataaaagtca gcatcccttc atgctaaaaa ccctcaacaa acttggcatt ggaggaacat 228120 

atttcaaaat aaaagccatc tatgacaaac gcatagccaa caccatattc aaggggcaaa 228180 

agctggaagc atttcccttg agaaccggaa caagacaaag atatctactc tcaccacccc 228240 

tatttaagat agtactggaa gtcctagaca gagcagtcag gcaagataaa gaaatacaag 228300 

gcatccaaat aggaagagaa gaagtcaaac tatatcagtt tgtagacgat atgattctat 228360 

acctgaaaaa acccatagtc tcttcccaag agctcttaga tctgataaaa aacttcagca 228420 

aagtttcagg atacaaagtc aatgtacaga aatcagtagc atttctatac accaacaatg 228480 

tccaagctga gagccaaatc aagaatgcaa tcccattcac aacaccacaa aaagaataaa 228540 

atatctagga atacagctaa ccagggagtg aaaaatctcc ataatgagaa ttacaaaaca 228600 

ctgctcaaag aaatcagaga agacacaaac aaatgtaaaa acattccatg cttgtggata 228660 

gggagaatca atattgttaa aatgaccaca cttcccaaag caatttacag tttcaatgca 228720 

atttctatca aactaccaat gaaattcttc acagaattgg aaaaaattgt ttcaaaattc 228780 

atatggagcc aaaaaagagc ttgaatggcc aaggccattc taagcaaaaa gtacaaagct 228840 

ggaggcatca cgttacccaa cttcaaacta tactacaagg ctacagtaat caaaagggca 228900 

gggtgctgat acaaaaacag acacatagac caatagaaca gaatagaaag cccggaagta 228960 

aagccacaga cctacaggca tcttgttttt gacaaagttg acaaaaacaa gtaatgggga 229020 

aaggactccc tattcaataa atggtgctgg gataacttgc tggccatacg cagatgattg 229080 

aatgtggacc ccttctttat accatataca aaaatcaact caagatggat taaaggctta 229140 

aatgtaaaac ccacaacatg aaaaccctgg aagataacct aggaaacatc attctggaca 229200 

taggctctgg cagatagttt atgaagacac caaaaacaat tgcaacaaaa acaaaactgg 229260 

acaaatattt tctcccattc tctagtttat ctgtttattc aattgatagt ttctcacagc 229320 

aaaagaaact atcaattgac taaacagaca acctagagaa tgggagaaaa tgtttgcaaa 229380 

ctacacatct aacaaaggtc taatatccag aatctacagg gaacttaaac acattaataa 229440 

gcaaaaaaaa aaaaaaccca ttaaaaagta ggcatggaca tgaacagact gtgtccaaaa 229500 

gaagacatac acatggccaa caagcatatt ataaaatgtt caacatcact aaccagcaga 229560 

gaaaggcaaa tcaagaccac aatgaaatac catctatacc agtcagaatg gctcttacta 229620 

aaatgtcaaa aaacaacagg tgctggcaag gttgtggaga aaaggaaacg tttatacact 229680 

gctggcggga atgtaaatta gttcagccat tgtggaaagc actgcagtga ttccccaaag 229740 

aacttaaaac agaattatca atcaacccag caatcccatt attgagtatg tgcccaaagg 229800 

aatataaatc attctaccat aaagactcat gggtgcgtat gtctattgca gcactatatt 229860 

cagtagcaaa gacatggaat caacctaaat gcccatggat ggatatacaa catattacac 229920 

agccataaaa agaactagat catgtccttt acagcaatat ggataaagct ggaggccata 229980 

atcctaagca aactaatgca gaaaaagaaa cccaaatgcc acatcctaac ttataagtgg 230040 

gagctaaaca ctgggtacac atgaccataa agaaaggaat atcaggcact gtgtcctact 230100 

tgaggctgga gggtgggagg aaggagagat ttgaaaaatt ccttatcagg tactctgttg 230160 

attatctgga tgatgaaata atctgtacac caaacctctg tgatgtgcaa tttacctgta 230220 

taacaaacct acacatgtac ctctaaacct aaaataaatt taaaaaataa aaagaagaaa 230280 

aaagaaattg tattcttctc ctaaaacaag gacacaggcc ttttttacag tctgtccatg 230340 

ccactttaaa agttcaatcc tccatatact tgcttaagta ctgattagtt tgttaccttt 230400 

ctaggcacaa atgatgttta gagaattaat tttaatgtca acagcaggac agtaacctgt 230460 

caaaccccag ggaggttgat cacacccttc agatcttaac cagaaagtgg ctgaaggaaa 230520 

gccattgcaa acccatgtct catttttgtc cctaaaattg agacatagaa ggcagaaagt 230580 

cagcatcagt ctccaaggac tttttgcaac cagtatttct gtgccaacat cttaggccaa 230640 

attattggaa tgaggtttaa aacactaggg gaagggagaa gctgaatatt ccccctaggc 230700 

taatagttgc ctggtgaaat gtcactgcat ttgtgtcaga atgcgcagag gaatgcaatc 230760 

ctgtctgggc agaaggcaaa tagaaaaccc aaaggagagc tgattcaatc actctgtatg 230820 

atttagaatg tattatggtc aacatagaca ctgatctact tttcccaagt tcctatattt 230880 

agggactgaa actgctgttt caaataaaaa aaaaacataa aatgaattat tctgaacact 230940 

tatacaaatc tgttagtgtg ttcaatttct cctgggaaaa tgcaatgatt tgatgacagt 231000 

tctggaaggg aacaaacaga agtatagaaa ggggtatggg gaagtttcag agagagagac 231060 

agagacagaa ggagagacat aaagagatag aaaggagaaa tacagaaaca gagtctcaaa 231120 

gaaagaaaac aaagaagggc agattcagag acaagttgtg aggcaagaac cagacagaga 231180 

aaacaaacac aaagaagtaa tatttagaac acagagaggc ctaacactga aaaccaatga 231240 

cataaaaaca aatgaaacac tgaaaaaatg tatataactt ttaaaaaccc aaggaaccag 231300 

ccagaggagc tggggaggga aaagagagaa aggaagataa cccatggcaa cacgcaattg 231360 

agtcaatatt tattgagtgc ccacagacag catggcaacc tactggaact taagtagaaa 231420 

taaattcaat tctctccggt cctgaagggt ggggaagctc aggtctgcca ttctgcctag 231480 

gggctgagga agtgtgagta catgcagttc tgcactgagc tctgcttgct gcagtttggc 231540 

cccagctcca cttccttggt ctgacctgca accttcttcc ccaaattcca ttgaagaaaa 231600 

acaaatactt aaagagacac aaagttttgt ttgtttgttt gtttgtatgt ttgttttttg 231660 

gtatttgtaa catcaggtct aaaacaagta ctattattag taataatgct atatttcttt 231720 

atgaaacata aaaatctgga agctagatgt tttcaaaaca gaaaggttaa aattttaaga 231780 

agagaccaaa caagagacca ctttcattac gtatcttccc tcccaggtcc tgacatatat 231840 

aataatacat agtattttaa aagcaccaaa accccctcct ggccaacatg gtgaaaccct 231900 

gtctctgcta aagatacaaa aaattagcca ggcatgctgg tgcgtgcctg taatcccagc 231960 

tactcaggag gctgaagcag gagaatctct tgaactcggg aggcagaggt tgcagtgagc 232020 

cgagatagtg ccattgcact ccagcctggg tgacagggca agactctgtc tcaaaaaaaa 232080 

aaaaaaagca cctcacatat cgccactaaa gaacttactc atgtaaccaa acaccacctg 232140 

ttcccccaaa aaacctatga aaattaaaat aaaataaaca aaacaaatct ctctaaattt 232200 

tatacaattt agtctagaaa atacgttgta agaatgtcag agtacacaga cacatatctg 232260 

atcaaaatgt ctccaaaaaa cctgcagaaa gggaaatgta gtctattata tgactcaccg 232320 

tgcccatgaa ataaaaataa accatggttt ctaagaaata caaccatttc tggcagtggg 232380 

tgctagaaaa tagatttgca aagaaaagac acaataatca aagctcatta tgttccatca 232440 

atggaccata cctattcaga ccaaactata cctggtaaac ctaaagaaag aaggcacata 232500 

gcagaataat ttgtggaata ttagcttatt tattcttcct atattttcct acctcacaac 232560 

tggaatttta gaactgctct gcctctagga tttttacagg gtggaaaacc aaaagacact 232620 

taaaagagat tttttttttg tcatattaga acttcttgaa aagactatgc tactattatc 232680 

ctgaggatgc aggatagaga gaatactttc agaagcttgg aaagagggag ctatgcctcc 232740 

tgaaccaaaa agagggtcaa agtcaagggc ccaggcattt ctcagtagca aaataccacc 232800 

ccagggaggt gttatgtgtt agtggaaagg atcacacagt ctggaacaga gagattctta 232860 

atggtaccca gtggacaaag gaccaatgac tacatctcag atgatgtggc actccctata 232920 

actaacttta ggaattcagc acaactctat ggtgtggcaa gtcccagtag tgacttcaac 232980 

tgaattctct accactctag caaaatagac tatgagaaca atttttgtta attttataaa 233040 

aaatgagcta tttcatatac attggagttt gtggtctaga tgtcatatat gctacacaaa 233100 

ccttggcgtc aaatagaatg aggtctgact taacttttgg tcatcttact taatttctcc 233160 

aagtcttact tctgtcatct gtaaatggag accaaaggta gaattttatt catttgttat 233220 

tataagttgc gagcaatagc tgtatgctca gtgcttagtc cagtacctgg aacatagtca 233280 

gtgttcagta atggtcatta tttttattca gtttgaaaaa tgtctcactc tagtaagaag 233340 

tcaagcaaaa ttttgacaca aagcttatac gtaactatta cagagggaaa caccatcagt 233400 

tatgcacaac tgtttacaag atttaaaaat gtagactatt aatagttctt caagagaaat 233460 

gcccctaacc atttcaggaa ggacaatatg aacatacaaa ccaagaaaaa caccgaccat 233520 

ctcccacaac tttctcagca gaggcccgtg cccattcaga tcaacgtgtc caataaacct 233580 

caaactcatg ggaaagaaaa attttaaaag caattcaaag ctttaatatg tcaatggctt 233640 

ttaaaaagtc aactgtcaca cttcttctcc ttttcttccc tcccttccct caacacaatc 233700 

gtgtttgagg ccaaagctat ttataattct tggagtgact gacgttaaaa gacttttgac 233760 

aagcagtcta gtgaccttga tgaaagtatc ttaatctgac agatagactt ctcaaatgga 233820 

atgtgggagg ggagagcata ctttaacttt tggtaagcta aaatagcacc ttgaaaattg 233880 

aatgacccta gatatggatt tagtagttgt acccatttca ggttataaaa gccctaagat 233940 

taaaaaaaaa ttgcaagtcc agctcaggat agaggaaggt tgatatttct gcatctaatg 234000 

tatgcctcta gctcattagg taataaggtt tgcattcaca ttaaaattct tagtgtgact 234060 

tcaggctctc ctcatttttg ctttcctcta cccttctcaa atgatttggg actaatcatt 234120 

ggtttcagtt ctctcaccaa ggggcccatg gtgaaaaaat catgacttaa caattcaaca 234180 

agcatttctt gagcatttgt tatgaactca ataccaggaa taccgacatg gacatagtct 234240 

ctgctgtcag ccctatctca aaactctggc agaggcttct ccagttatat agtttggata 234300 

tttgtccctg ctcaaatctg atgttgaatt gtaatctcca gtgttggaga tggggcctga 234360 

tgtgaggtat ttggttcatc caggcagatc catcatggct tggtggtgtc ctcatgatgg 234420 

tgagcaagtt ctcatgagat ctggttgctg cgaagtgtgg cacctaccca ccccctactg 234480 

tctctcttgc tcttgctttt gttatgtgaa gtgccttctc ccacttcatc ttccaccatg 234540 

agtaaaagct ccctgaggcc tccccaaaag ccaaacagat gccagaacca tgcttgtgtg 234600 

acctgcagaa ccatggacca actgaacctt tttttaaaat aaattaccca gtctcaggta 234660 

tttctttaga gtaatgcaac aatggcctaa tacagaaaat tgatatttag aagtgaggca 234720 

ttgctataaa gatagatacc caaaaatgtg gaagcagctt tggaactagg tgacaagaag 234780 

atgttagaag agtttcgaca tctcagaaga agacgacagg aagatgaggt aaacttcgca 234840 

aatttttaga aacccattaa atggttgtaa ccaaaatgcc gatagtgata tggacaataa 234900 

aatccaggct gaggagattt cagactgaaa tgaggaatta ttgggacctg gagcaaaggt 234960 

cacccttgtt attccttagc aaagaatttg gctgtattgt atccatgcct taggaatctg 235020 

tggaagtttg aacttgagag tgacaaccta aggtatctag attgaaggaa gacatttcta 235080 

agcagcaaat tgttcaagat gtggtctgag ttcttctaac agcctatgtt cagataccag 235140 

agcaaagaaa tgacttaaaa ttgaatttat atttaaaagg aaagcagagc ataaatgttt 235200 

agaagatttc tcagcctagc catgtggcag ggaaagaaaa agcatttttc tggagaggaa 235260 

tccaagcagc ctgcagagaa accacttgct agagaaattt gcataaataa aagggagcca 235320 

agtgctaata gccgagacaa taggaaaaca attttgaaag catttcagag acttttgaga 235380 

cagcccatca caggatcaaa gacctaggaa ggaagaatga ttttgtgggc caggcccagg 235440 

gctctgctgc cctgcacaac ctcaggacaa tgctccttgc atcctggctg ctccagcact 235500 

agccatggct caaaggggcc caggagtagc tcaggaagca gctccagagg gtgcaagcca 235560 

taagtgttgg tggcttccac atggtgttaa gcctgcaggt atacagagtg caagagtggt 235620 

ggaggcttgg caccctccac ctaaatttca gggaacatgt agaaaagcct ggatgtccaa 235680 

gctgcttatc agagtgagcc ctcacagaga acctctattc aagtagtgca gagaggaaat 235740 

gtggcatagg agtccccaca cagaatcccc accagggcat tgcctagtgc agctgtggga 235800 

agagggccac catcctccag acccaagaat ggaagaacca ctggcacttt gcaccctcag 235860 

tgtagaagag ccacagacat gcaactccaa cccatgacag caaccacagg gaccgaaccc 235920 

tgcgaagcta caggccagag ctgccaaagg ccttgggagc tcacaccttg caccactgtg 235980 

tccagcatat ggggcatgga gtcaaatgag actattttgg agctataaga tttattgact 236040 

gccctgctgg gtttcaaact tgcatagagc ctgtagcctt tttcttttgg ccaattttcc 236100 

ccctttggaa tgggaatgtt tacccaatgc ttgtactcac attgtatctt ggaagtaaat 236160 

aaattatttt gactttacag gcttataggt ggaaggaact tatctccaga tgaaactttg 236220 

gacttagact ttagacttgg aacttttgaa ttaatgccag agcaagttaa gatttggggg 236280 

tactattgag aagtcatgac tgtatttcgc agcatgagaa ggatgtgaga tttaggggtg 236340 

gagaagaggg gtggaatgat atagtttgga tatttgtcca tgcccaaatc tcatgttgaa 236400 

ttgtattccc caatgtagga gatggggcct gatggaaggt gtttttgtca tgcatggagg 236460 

caggtcccca ggacttggtg cagttctcat gatagtgagt gagttcttgc aaaatttggt 236520 

tgttgtaaag tgtgatacca cccctgcccc gacacacata cagtctctct tgctcttgct 236580 

tttgccatat gaagtgcctt ctgttttgcc ttccgttatg agtaaagcat gtacaagcat 236640 

ggcactggaa tgtactgcag gctgtaatac gtgagactgg ctcatttatt taaaaaaaga 236700 

ggtttaattg gctcatggtt cggcaggctt taaaacatgg cactggcatc tgcttggctt 236760 

ctggggaacc agcttctggg aaccatgaac ggcctaatac acccagcttc ttatagctgg 236820 

gcccattcat tcttgtctac cacccaatct cttgagccac ttcctgtggc tcccacaacc 236880 

tcccactatg gcattgtatt tttctttctt gtacagttac agagcagcta taattcaaga 236940 

tttatgaact tttgaggttc attcttctga tgatgattgg aactcatgca tgagtttcca 237000 

ctaatgttcc attttataga aaagggcttc catttttatt ttggcttcca ttttcattct 237060 

tgttctagaa gtcttcatga ttttctagat ccttcctacg aagagtttcg tttcactcag 237120 

acagtcctgc ctctctggag ataaggcttt attatccaga gcaaaatctt agtggctgtg 237180 

atctttctac ctgcacacaa gcttccctaa tgacatctgt ttggatttct atgttctatt 237240 

tgtacattac tttgtgccca cctccaggag aactcagtgt gagcttgtaa ataataaaca 237300 

gacactgtgt catattctaa agctatggag ataagacaca gaacctacaa tcaacaacta 237360 

cagtctcaaa gggaaaacaa taaggcaata gacaattata agtgatttat aactataagt 237420 

agcagaagta ttcagaaaca ccatgggcat agagaggaaa agcccaagtc ttctcatgaa 237480 

agtgaaggtg ggcatcacag aggaggtgag gtttgagtgg aattgtaaag gtgacatagg 237540 

agtatactag atgaactaaa tggttgatag gaaaaacggg actgggtgaa ggtacacaga 237600 

ttggaggtag tggggacagt gtatgcaaaa gcctgggata tacaacagca tggtatatct 237660 

aaggtataat aaccctgtat gttttgctta ggagtttgac ttttatctta taggccaaaa 237720 

cagcaaataa aattaatctg gagggcctac agactcctgc ctctcatggt atttagtaat 237780 

gtctattgtg gatgaggaag acaggactgt gaatcaaatg ctgtctgttt gcaatctaag 237840 

catagataaa cttgagccac tgaaggattt tattaatctg taaataatgt acctgcaagt 237900 

ttctgtcttg tgactccaag taggagagct tccttaagat ctagcctggc cttgtggatg 237960 

tatttactga ccatgtcagg atttttatct ttccagactt ttttttttct ttttagatga 238020 

agtcttactc tgtcacccag gctggagtgc aatggcacca tcttggctca ctgcaacctc 238080 

tgcctcccag gttcaagcaa ttctcccacc tcaccctccc aagtagctgg gactacaggc 238140 

gcctgccacc acacctggct aatttgtttt tgtattttta gtagagatgg ggcttcacca 238200 

tgttggccag gctggtctcg aattcctgac ctcaagtgat ctgcccgcct cggcctccca 238260 

acatgctggg attacaggtg tgagccaccg caactggccc agacattttt aattgcaagt 238320 

aaacagcctg tagatttctt tgaaggtttt aatatttgcc ctcaaagtga gaatattaaa 238380 

ctatggaaga ggaataagca aacaaataaa tatgaatagt gtgataagtg ccataataaa 238440 

ggtacattct taaaagcctg caacataatg cagagagaaa aactctacct ggatgattag 238500 

agaactcttt atcaagtaga taatacaaaa gccttgcatg acaagttaga actcttagag 238560 

gtggagaagg gaatttgcag aagaggaaac agcctaagct aagagcacta gtgtgggggc 238620 

atctgtggtc tattcaggaa acagcagaga attttgtatt gacagtgtgg tggtaaacca 238680 

ggactggtgg cagatataca actgtaaagg caggttgagg caattgtgaa aaaccttgta 238740 

taacatgctt tgagcagagc tgtttcttag acacacctct gatgtggtaa ggagaacagg 238800 

ctgtaactta gcatggagac agagagagta gtttaaaatc cagtaaggca ttcggagcag 238860 

agaagctgat ccagaagtaa gagcatgcac cccctatccc gctgcctgga aaaaatgcag 238920 

aagtccagat tggagttaca gttccatcac aaatggccta tgattcaggc tgtgggaaca 238980 

cctcaagcaa tctcagcctg atagagccgc cagtgccctc tgatggtggc ctgtttgatg 239040 

gccagaaatc aaggcaccat ctaattcctc ttccatttcc caaggtttta ccaaatgctt 239100 

ggctgctgtg ataactgctg gagccacaga tcttcaagac attggtcttt caatcgaaaa 239160 

gctcatagtc tggtcatcct gatgtaagac acagagatga gcatatcatt ggtctatgca 239220 

ataaaaaaat atgcataaga aagttgtata gaaggatgat taactcagga ctcgggggct 239280 

ttgatggtgg tttgatctct gggttggtag tgaaaatata cccatggaag atgtaattgg 239340 

cctctgaaat aagattagga cttcagaagg taattaatag gaaggctttc attgagacca 239400 

acatgggtta tttggaaaac tgaaagtaag tctgtgttct agaagcatca acagttggca 239460 

cagattttgc agtggctctt ctgaggaagt cttaatgata ctcaatgttt cctacagggc 239520 

ttcactcagc aaatatgtat taggcatctt ctacaggcca agccctctgg tgagcaatgt 239580 

gatatgggac ccccaaggtg cttacagcga agcattaaga cgggcgttca gacagaaaga 239640 

tatgaagggg tactttcttt aaagttcaag ttgtacacaa gtagcagttg gcagcaaagg 239700 

gaaacaggct tttacatgga agggggcagt caaggaaagc ttcccagaga aggaagtgct 239760 

tgagttgaac tttgaagaag aaatgagtag gaatttcccg gatgacagtc caggaaaggt 239820 

gtggcaattt tgtttctgtg atgtggctct agatgagtgt cttcctgcct ctctagtcat 239880 

gtcatctctg ctcttctctt caggctcctc ttcttcccac ctctactgtg attgatcctt 239940 

caaggttctg tgctcagccc ttccgttggt tcttggattt gtcctttccc gccatgtctt 240000 

catcacatcc acaacttcca ctaacacttg cgagcttcaa acttcttagt aagtaaagac 240060 

tccacattgc caagtacagg actttttacc caggaagtca gcctatctct aatgaaacat 240120 

gctccaaaaa taacttacca tctttcatct ctgttgtccc acctatcttt ttgtggcctg 240180 

attttataag tcaagaaccc tgaagagatc cttagcttgc ttcctttcta ttcccaacat 240240 

ccagtgactc tccaagttct gcagtgctct taaatccttt ctgtgtccac tgttaattcc 240300 

ttaaaggggt ccctcataat ctcttgcctg tctgattgca gtcacttcct aatctgtctc 240360 

tctatttcca gctcacactc taaacctatc cttcctcact actgctgggg tggtattccc 240420 

aatcagcaag tctgattttg gatcatatcc cacttcacca cacccctact gcttttgata 240480 

gtcccatgtt cctgacaacc tttggaatta ggtctcaatg ccttagggtg gtagacaaac 240540 

ctctcctgct gacctcatca gtagctttat ctgttgtcct ctcccttcag gaattcacca 240600 

gaaattctaa acggattgta gatctcccaa aatatcattt tttttcatat tttcttgcct 240660 

tgaaatgcta tcacctgtaa tgttttccct atcactcttt ccacatgaca ctgtcacgtc 240720 

cccttccttg actctgcctt ctggatagat ggccactttc ttttctgggc tacttctgga 240780 

ccaggtattc tgaactatct attattatgc cactttgtga aaatcaaaga agcaatatag 240840 

cttaggagtt aggaaaaagc aaccaaatcc cagctctgac acttaccagt gtgaacttag 240900 

gcaagttatt taatttctcc ttggcttaat ttctacaaaa cttagctata aaatgggact 240960 

gataatagta tctgcctcat aaaattgttg tccagttaat gtatataaag tgctttaaac 241020 

aaaaaagtac tgggcttata gtaaggatta tataagaatt tgatgattgc caactgtgag 241080 

catctcgatt tgagggaact atgtcttgtt catctccatg ttcccagggc ccagcaccag 241140 

tgtcttacac acagggtatg tggaacaaat gtttgtttac agaggaatga ctgaatctct 241200 

ggcttttcct ttcccttggt gtaagaccca gtaaatccct gagtcatgct gattttcctt 241260 

tccaatgtcc tccgtgttta atttttttct atggtaacta tcacagctcc ttcatttatt 241320 

cagcaaaaag ttattagtca acagtgtgca aggcacccta attgctagag ataactgctg 241380 

taaacaagac agattccttc tgcttatgga cattgcattc tagcagagga cacagacatg 241440 

aaataacagc acattaatta cctgatcaag agtgatatat ataataggag tcttggggag 241500 

gtcagaaaat ttctcttaga taaaaaattt gactaatata aaaaaaaact agaagtaaat 241560 

agctagaata aggtggtaaa agctgtggtg gagagtgacc caggcaaagg gaatggcatg 241620 

tgtaaagctc tgaggtagga agaaatttaa catgtagatt tttagttccc tgtgtctgga 241680 

ttattgctac aactgctacc cgatttctgt aaagaatgat cgtccccact gctctcatat 241740 

taaactttcc atcatgtaga ttccctgctc aagaaccttc catgattctc tattgcctac 241800 

tgaatgacat gctaattcct gagttgtttt tcatgtccca atataatatg ggtttcagtg 241860 

attatccaat tttatcttcc acaaatcatc taccatatac tcaccatagc catcatgaac 241920 

tacttgatat tctccacaca ttctttatgt tttcctacct ttctaccttc gttcaggttg 241980 

ttattgctac caaaatgcct ttcttctctg ttcctatcca tgcttgtttc acaaaaaaaa 242040 

aaaatccatt tgctatatat gtgatgtgct ttgatatttt ctattctagt ctattacatt 242100 

ctagttcagt ttttaagaca aacaagcaag atgtaagcca cataagtgat ttcgtaactc 242160 

atgaatggat cttgacccag ggttgaaaac attgtcctaa atagctttaa agattttttc 242220 

atgatctatg attttgaaga gggttggctt tactagagtc aaaattttct tcttgcagta 242280 

gaatcctcta accagctaca tctggattat tagtcatctg tattctctga agacaggaca 242340 

gtgaaattca gcctgaacac atgatcaatg gggaagctaa tcatacagat ccaaagcacc 242400 

ctaaggatgc ttagtaatac atcttgattt gtaggtgata tcacactttg ctatttcaat 242460 

cctgccaatg atctgaactg aagttgctaa ttgtattgaa ctgttccgga tcacatcttg 242520 

ggcaaagacg aacatgggag agcatttgtt ccagctgaga ctgagaaaaa aaaaatcctc 242580 

ttttagcaaa taaatccata gcaactagat gcaactgtag ctcatgttat ggcccatcat 242640 

ctctttctct aagacagaga acctgggcat cggccgcccc cttctttaaa taacctacca 242700 

ccaatcctct tgactttaca tcctacaagt gtctccgatc tgttgacctc tctccaactt 242760 

tcctgccttg cctggagctc aagcctccta aatgtttatt ttgcaatctt tcttagtgtt 242820 

tcacacagtg aaagatctat tgtgccatcc tcctgctaag aaccattcag ttatccgctg 242880 

tttgttccct taggagaggg tccagtggat actacataaa attgcttgca aagcccttcc 242940 

tgatccatcc tcagtaagct ttcctgtctc attcttactc ccttctttct tcttttcctc 243000 

ctccttgtct tctcttccgc cattcatctt ctaccctctg atcattaaaa acaaaaagct 243060 

ttgttcctca aacacttcat gtttgttttc tttggtttgg ttttctggtc tagagcattc 243120 

ccttctttat tagacagctc ttatccttcc ttcaaaacac atcttggata tttcattcct 243180 

tgagctttct aagtcaaagc catgagactc tcccctgtcc tcccttaatt ccctatagtt 243240 

caccattaca ccatatccaa attatccatt cacttcactt caacagtgtg aaagcaggac 243300 

tttttcagca caatatttct attgcctatc acataatagg agaaccctgc agtgtccagc 243360 

taagctgatg acttgaagat aaatctgcct aaccctggga tgaagtatct gtgaactatt 243420 

ttgacagcag atgtaagtca tgatctccaa agaacttacc agttactatt aatatttttt 243480 

tttacttagt atgtttaaat ctccatttgt tttatgtatc tcatttcata aattcaggag 243540 

tgggtgaaaa aaagaggtgc taattttggt tccctgaaat tccaatattt caggtaatct 243600 

ctcttagaca ctaaatttta cttcttacca ggcccaccct ggccaatata tagatcctca 243660 

gattaatggg gctttcacaa cagttttatt caattattct caatcatcca cttttcattg 243720 

attaaacaac tactaagtgc tagatactgg aaatactaga tggttaagat gtcatccctc 243780 

ccctcaagac ctagtctatc ctgagctcca aggagggaag ggaccaaaca gtaagctatt 243840 

atgaaataga agttcttaca taaactttaa cagccaaaga gttccacaga agcataaaaa 243900 

tgttaagaaa tgagagtttg ctttccgtac aaaaaaagaa aacaccaagt aagttttatg 243960 

aatgataaat attctgagag agaaacacac agcaagctgc agataccata cagagaagtt 244020 

tttgtttttt tttttgctaa tggaaccatg aagattccca ttgcatccac tcacatttag 244080 

tcagtgctat tttagttaat tctaatggat tcttttctct ttaagtttta tttatgtttg 244140 

attgacacac aatgattgtg caaatttatg gagtaaaatg tgaatgtttc cctttataac 244200 

tgaaaagcaa gtagcctagc aaagtctaca aatttcttca aaggcataaa agcaaaatat 244260 

agccaaggtg atgcagcagg tgttgcaggt tgttgcaggt gttgcaggtg ttgatgggtg 244320 

gtcaacattt acaggttgtg ctgattatta aactttgaat gttaatgtgg aggctgctaa 244380 

tgctaacact agaaagttag aaatgtattc tgaaggattt ttgacttaag taaaattaga 244440 

aatgagcaaa acctttctgg tcagaatgat tctacaattt tcacaagcca aaaattattc 244500 

aaaatgcatc tctgaggctt ttgcataagt atttaggacc tctttgaatt tcttgctatt 244560 

cctgtaacat atttgcttta taatacgtta tccctttgca gttctttctg gttggaatag 244620 

ctccctgccc ctcaggtgcc cagtaaactt aattgtcact tctgtgaagc cttacaagat 244680 

cagtgggaat cccttaggct gaattaataa cttcccactc ctagtggcca taccactcta 244740 

tgactttcct tttaaattgt ccttactcca ttatagtatt ctttgtagaa ttgtctctgt 244800 

tccctaacag actgtgtaag ctacttaata attccataat tccttagcta caggacccaa 244860 

cagtgcctta tataaatttc cataaaggca ggtttaatgg gtgaatcatt ctactttttt 244920 

ctttgcctct tctgtgtcac catagtacta agtctctgtt ctctttcatg gtcttttctt 244980 

ctccagtttg aaaaacttta tgatgtacaa taaggtctca cataacatta ttggtaggtt 245040 

cttgaaaact gcaactttaa gtgaaatgat gactattgaa gtcaatttta ccataggcta 245100 

actaatataa aaaagagata aattcttaga gtgtatttct gctcacaaaa atgtcaccaa 245160 

acttctaact aaaaaacaaa acccttctaa tcttaaacct tgagataaat gtaagctata 245220 

catccattta agaaagatta atacaaacaa gtaagataat tatttaccct attatttcag 245280 

ttcatggtca caggtggcca aagtccttcc tgacagctca ggtagccaag cagaaaccca 245340 

tcctggacag aacaatgtgc aaactccaca cagacagtag ccccgatggg gaatcacatt 245400 

tttttctcat caatgttata atgaaatgaa gttgaataaa atggcattga ataaaatatt 245460 

atttgagtgc ctgttgtaca ttactaaaaa gttctaattt gaccattaga atatatatta 245520 

tttttaatta gttacaaatt tatcttagaa aaaagtagga gttctagttt aagagccatt 245580 

tttgtcagtt tgggacaatc actttacttg tcttgacttc agtttcctca tccaaataac 245640 

gaggacatta ccaaatgatc tgcaaatcca gcgcccactc ccccccaccc actctaatat 245700 

tacggtccca tactctttct gaattcatga aaaacgcata gtctaggtca cataatagta 245760 

cacttaatta acagttttat tatcttgtct cattacttct ttctttgctc ttcctcaaaa 245820 

acacataacc aaatagtaag ttctatgatg tctgaagaac tcagaaagtc aaaccgatac 245880 

agatttaagt cctgattctg ccatacgaaa catctttctt gtcaacttcc tcaacatgga 245940 

taaggctcag tttctcatgt gtaaaatggg aataataata gtagtacttt ttaaatagag 246000 

tcatagctag cctccttctg catttcttac gagttcctgc aattggcagt cgtgtaagaa 246060 

tgcaaggtct taataacaca gatacgttca ctgatgaatt aatcactagc ctgtgttttc 246120 

gcccgttatg tcaaagcatt tttatctgtt tcttgctgat tgccagatac tgtaaatacc 246180 

taatattaca ataaaattac agtgccaact acatatagtg ccaactaaaa ttgtaaatct 246240 

tgcaatatat gcaaatcttc atgaagttga taaacacaga gctaaataat tgtaaggaac 246300 

acaggtgaag ccattgacaa attgaaaaaa agaaaactaa tgagaatatg acagactagg 246360 

caccataaag acactaaatg gaaaatgctg attaaataga tacatgactc taacattttt 246420 

cacaaaacta aaatcatgtg gcaaatcttt aaaaaggata gttttgtatt gttatgcaaa 246480 

tgctcaaaat taattattta attcattctt tgctctttct aaggaataat ttatggaagt 246540 

aatgagcaag aggatgaaat tcagcatgag aataggagca tctcacagtg ggcactgcag 246600 

agaaagtggg ggacagtgag aagcagcaaa ggcagcccac tcctcattct caattctgac 246660 

acaggccaac tctggtgctt acccttagca gcaaaatgag aaagcagtgg acaaaaacac 246720 

aaggcggatc attgaactct gtgtgtctga tacctaacac cttattgaag tttcaaccta 246780 

agcaagtcta ttcaaatatt aaaaaactaa taatgtttaa acttccataa aaccttagtg 246840 

aacactaatt atttctatag cattttgcaa taaataaaag taattttact gctttttgtt 246900 

caacgaataa ctctgtgagg tagttgaaac agatattacc tctattttac tactgaaaaa 246960 

ccaaatgttg gtaggagctt actcaggtac tcagagaaag aacacaggtc ctggacccca 247020 

gggcatattg ataaaaatgt tttatgtcat tttcatctga ccagtaatgt agttcaaatt 247080 

ctcattataa tctttttagg gtatattttg ttggtcccaa ttttctgaaa gataagaaat 247140 

ctgaggattg aagagattca ataaactggc ccagagtcag tggtaaatat cagtttccta 247200 

attccatgat ccctgctttc tccaggacac tctccccttt cactatgtca ggttgtttgc 247260 

taaaactcag aatcaaatgt ctttattaat aataggaaaa ctataccaac agaaacgagg 247320 

ttttcagaga ataatagaaa tttagaaagt ttgtcttaga aaaagtgact gcagttcata 247380 

cctcaattat aattactggt acatttagga actgaagttt aaaagtgatg catttgtttc 247440 

aacgttgttt cctttttctg tgtacttcct ataggtgata ctaaagagca atgaaataag 247500 

caaaagctat gttgtaccaa aaaaaaaaaa aaaaagaatc tgtgttttgt attaatccct 247560 

gagctcagta gatcattgcc tctatcatcc cattttacca attgagatgt gaactataga 247620 

gattaagtga actttctagg gtcacagagt tccaaatcgg ctgagcaaat atatcagtgg 247680 

ttcttgagac attcactgta ttttatgact atcttttctg taagcatatt gtagtaaaaa 247740 

tataaaattt tgtttaataa agcaacgaag agaatacata agcagaaatt attcccagta 247800 

aactggcctg aatttatgtg ttgtgagtga tgagtatgtt tctactacta ttgcaactgt 247860 

agtcatgaat tatttgcgaa caagggccaa gaatacatag tttaggttat attaaaattg 247920 

cagttaagaa aatattttcc tctgggaggc tgaggtgggt ggatcacaag ttcgggaaat 247980 

cgagaccatc ctggctaaca cagtgaaacc ccgtctctac taaaaataca aaaaattagc 248040 

cgggcgtggt ggcggtgcct gtagtcccag ctacccggga ggctgaggca ggagaatggc 248100 

gtgaagctgg gaggcggagc ttgcagggag ccgagatcat gccactgcac tccagcctgg 248160 

gcgacagagt gagactctgt ctctaaataa ataaataaat aaataagagt gaaatccaaa 248220 

cacaagaaat ccatgctaat ccacatcaaa ataaaaagaa aactaagaac aaaaaaatct 248280 

tgaaagcacc aagaaataaa tgacacctga actatcaggg gaaaaaaaaa tttgaatgac 248340 

agtggatttc tcatcagaaa tcataatgat cagaaggaaa tggtacaaca aattcaagtc 248400 

ctgaaagaaa agaactgtca aacccaaatt ttgtatgtgg caacattttc cttcagaaat 248460 

gaaaagaaaa taaatgcatt ttcagattaa tgaaaattaa gagaatttgt cacaagccac 248520 

atacattaaa acaatggcta aagaaacccc ttagagaagg aatcttaaaa catcaagaac 248580 

aacaaatata agtaactaca aaagacgttc cttctcctct tgtgtgttct acatttagtt 248640 

tagtagtcaa agctaaaagt acaatatttt ccaatatgaa tctaaatgta tgtagcaaaa 248700 

acatttaaga gaactatatt ataaatgggt tgggaagata ggtacagaga cttaaaagaa 248760 

ggcaagtttt ctatgtttga cataaattgg taaaatatta acaccaacaa atctttgtgg 248820 

tggtggaaga attctgtatc ttgcttctag cggttgttac aggaatgcat acatatgaaa 248880 

agatggcata gaactataca ccacattgta ccaatgtcag tttcccagtt ttgacattgt 248940 

actattgtta atacaagatg taaccattgg gagaaagtga gtgaagggta cccaagaact 249000 

atccattttc caaattatga atccacaact atttcaaaat aaaaagtaaa aaatgtaagc 249060 

ttttaaaaaa ttcttattaa gtcacattct gaaacacctt ctaaccttaa aaaaatggga 249120 

aaaagcccat aataaagagt tggtataaaa ttacagagca aatttcttca gtaattgatt 249180 

gttttgcttt agttaggttt ttgatcatca tttgtgacct acttgaattg gggaaatgca 249240 

actctgtttt gatgctgatg ttactatcaa tgtctgcttt tttttttttt ttttttgaga 249300 

tgaagtttca cttttgctgc ccaggctgga gtgcaatggt gcaatatcga ctcactgcaa 249360 

cttccacctc agcggctcaa atgattctct tgcctcagcc tcccaagtag ctgggattac 249420 

aggcccctgc caccacaccc agctaatttt ttgtagcttt tttatgtctt caataatcac 249480 

attgtataaa agctaatgag ttatcttggc taggtcataa agataactga caactttgtt 249540 

aacagttcct aaataaaaat attatttata atcttcagct atcagagtat agtgatagac 249600 

accttggaag tctacaagca tttttttctc tttcagagaa gtgaaaaaac tagcataaga 249660 

gtctctggat gtcttagtgg cacaactaga tagtggcatc aagctatgaa acatccaggc 249720 

catattacca aactttttaa tctaccgtga aaatccttgt ccttttaatc tgtagcaaac 249780 

atttttctgg aaactctaaa agcccatatc gctcctctca gaactgaccc cacttcccca 249840 

gtacaactct atttggatta tataatctcc actggtctca ctggactagt taatatgatt 249900 

gtctctccag ataattgaga attatgaccc atagattcaa actgggtaaa cttaaggttc 249960 

tatgttgcca gttggctact gctattactt ttggatttta tcaatgatga gatattccaa 250020 

acacacagaa aacacccatt tgctcccttc cctgaatgaa cagatattaa tactctgtca 250080 

taattctttc aaatttcttt ttccctaaaa attaaaaaaa ttttgatata gacacaaaat 250140 

taaagtagta ctagatatac caatcaccaa gataaaacaa taatcgatat tttgtcgcgt 250200 

tcacagaact aatttattta tttattttta aaattatggt agaaaacaca ttttaacata 250260 

acatgtttaa cataaaaatt agcatcttga ccatttctaa gtgtatagtt caatagtgtt 250320 

aacaatagtc acattgttgt gcaatagatc tctaaaagtt tttcattttg caaaactgaa 250380 

actctatacc catcgaaaaa caactctcta tttccccttc ctcacagccc ctgacatcca 250440 

caattctgct ttctatgagt tggaccaatt tagatgcctt atacaggtgg aatcatacag 250500 

tgttggtctc tttgcgactg ggcttatttt acttaccata atgtcttcag ggttcatcaa 250560 

tgttatagca catgacagaa tttccttctc tttttaagct aagtaatatt ccactgtatg 250620 

tatatactcc attctctgta tccatttata tgtcagtgga catttgggtt gctttcacct 250680 

cttggtattg agaataatgc tgtaatgaac atggatatga aaatacgtca tcaagagtct 250740 

gtcttcaatt cttctggata tgtacccaga gtgggatttc tggatcatat ggtaatcgca 250800 

tttttagttt cctgaggaaa ctctatactg tttttcttac tggctgcatt gtcaattccc 250860 

attgacagtg cacaagaatt gcaatttctc cacattccaa taccacttgc tattttctgt 250920 

ttttatgaca gtggccatgt gtattagtcc attctcacac tgctataaag aactacctga 250980 

gactgggtaa ttgaagaaaa gaggtttgac tcacagttcc ctaggctgta cagaagcatg 251040 

ttttggaggc ctcaggaaat ttacaattat ggcagaatgc aaaggggaag caagcacatt 251100 

ttaccatggt gcagcaggat agagaccgag agaaggggga agtgtgccac acaactttaa 251160 

accatcagat ctcatgagaa cacactaaca gcaaggggga aatctgtccc catgagcaat 251220 

catctcccac caggcccctc ctctgacatg tggagattac attttgacat gagatttggg 251280 

tggggaccca gagccaaacc atatcaccat cttaatgggt gatatctcat tatagttctg 251340 

atttgcattt ctctaatggt tagtgacatt gaatatcttg tcacttgtta gccatttata 251400 

actcttcgga gaaataccac tttgaggatt ttacccattt ttttaactag gctatttgct 251460 

tgttgttaaa ttataggcat tctttatata ttctgaatct aactccttac cagatatatg 251520 

atttggaaat attttctccc atctcgtagg ttaatttttc actctaagga ttgcttcctt 251580 

tcatgtgcaa aaggctttaa gtttgatgta ctctcatttg tctatttttg cttttattgc 251640 

ctgtggtttt ggtgtcatct ccaagaaaac attgccaaat ccactgttat aaaatttttc 251700 

tcctgtgttc ttcttatagt tttatatttt aaggtcttat gcctaggtct ttaattcatt 251760 

ttgagtttat ttttgtatat tgtgtaaagt aaggatccga cttcattctt ttgcatgtgg 251820 

atatccagtt ttctcaacac catttattga caggactacc ctttaagccc attgtatggt 251880 

tttggcactc ttgtcaaaga ttgattgagt gcgtgcacaa gggtttatct gggacctcta 251940 

ttctattcta ttgatccata tgtctgtcct tatgtcagta ccacaccgtt tagattactg 252000 

taacttggga tcacttaacc tatttaaaac acgttttttc tttttcttat ttgaagtatt 252060 

tttcagcaaa tatcagatgg tattatttta ccccttcata attcagtata actctaaaaa 252120 

ttatggccca ctacaaaacc acaatattat tatcactcat aatgtttctt tggcataatc 252180 

tcatacctgg tcttaatcaa atgtatggat tttctcaaaa atgtgttttc tggcttactt 252240 

gaattaaaat ctaaacaagg tccacatttt aatatgtttg ttttttaggt cactcgtaat 252300 

ttagaatagt tcttcctctg ctcccttttc cttcagccat tcacttatag aaattagttt 252360 

agttgttcta tagaatgcct cccattctgg atttctctaa ttctttatta tgtcttttaa 252420 

cactaaatgg aaattagcta gtggcttaac tctgtggtca tttaactata aattgaaatt 252480 

agcctagaac cataatgttt ttatgtctgc aagcagtttt ttaatcttat ctgcaaatgg 252540 

aagattctga ggacttttcc cagtttcact gggcattctc acatgtctta ccatgtttcc 252600 

acccaaggaa tataggatct tcttctttta gtagatgttt gtagaaaaat tttttacacc 252660 

ccgagtttgt ggcatacata ggttgtccct attcattttt cactattact gtcacacaac 252720 

ttcgttcttg ttcttgttct tgttatactg ctgtaagtga tttaccattc ctgttcataa 252780 

tctgaaattt atgagaattt attgcctttg atttttattt aagatattaa cagtgcattt 252840 

attattggct atcctaattg atttgtttgt tttccaggag gaattttggg gaaattaaaa 252900 

cctgcctttc tgccaggatc acatcactgg aagctccatg actctctttt tgtaaaagaa 252960 

aaaaaaatca cagaaacacc cacctcccaa actattctct tttacttctt cccccaagcc 253020 

cacccccaaa tataactgtt atccagaagc tgttatgtcc tgtttccata catgtttttg 253080 

tacttttact atatctacat acatcaatta aacttatgtc ctattgtttt gtgaatttat 253140 

atttgcgtat acattatcat atgtaaaatt tgcatttttt tattgaaaat tatgtttctt 253200 

gagatttatc cacattgaaa catggagctc taaatcgtta attttaaccg ctatagagta 253260 

ttccataatt tgaataaagc ataatttgtt tgtacaatct cccgccaagg gaaaattatt 253320 

tccacactca tcatgacaag gagcactgca aaaataaaaa taaaaattac attcatacat 253380 

gtttgcctgc acccatctgc ctgattttct ctaaaataaa tatctaggag tgaaagtgcc 253440 

aggtcaaaga gcatgtgcat cttcttatgc ccacatatat gagagttttc cccaagtata 253500 

tctacatcaa cgtctatgat gttttaattt tctacatcct tctctgtatt catttgtttt 253560 

catgctgcta tgaagaaata cccaaaactg ggtagtttat aaagacaaga agattaattg 253620 

gctcacagtt ctgcatggct gggaaggttt cataaaactt acaatcatgg tggaagggga 253680 

aggaaacacg tccttctgca catggtggca ggagagagaa atgccaagca aaaggaggaa 253740 

aagcccctta taaaaccatc agatcttgtg agaatgaact caccatcatg agaagatcat 253800 

gagtgtaact gcccccatga ttaaattacc tcccaccaag tcctcctatg ataaatagga 253860 

attatgggaa ctaaaattaa aggtgagatt tgggtgggga cacagagcca aaccatatca 253920 

ttgtcaatgt gaaatagtac tttattgtta ctctattata tattttattg aatgaaatgt 253980 

gaggttgaga acttttacaa gccctattaa tcattttgtc ttctttttct ttttctgtgt 254040 

atggtctgtt tataacattg ataatctctt gggttttatg tcaatttctt aatgatttgt 254100 

gagggtttaa aaaatattct agataatgat tcttcttgat atttattaaa tacaatgtgt 254160 

tctcataaaa tcatctatga attcttcctc ctatcctcct ctccattccc tttcctctgc 254220 

cttcgtctct atctctacat ctacctctac ctctacctct agctctattt ctagttatag 254280 

ctctagctct atccctgtcc ctatccctaa ccctatctct acctctagct ccacctctac 254340 

ctctacctct atgtctagct ctatccctac ctccacctct agtactgata ccagctctag 254400 

ctctacttct gtctctacct ctacttcatc tctatctcta gttctacctc tagttctacc 254460 

tctagctcta gctatactta tatctccacc tcatctctat ctctagctct agttctagct 254520 

ctacctctac atctagctct agctctatct ctacctattt ctatctctat ctcgatctct 254580 

atatctatct cgatctctat ctctatttcc ataacgcttt ctctccctac agttcagatt 254640 

ttgttcttgg aaacagcctg ggaaacaggc agtttactat actttctatt ttcccaaatc 254700 

tccatctcta accacacctc acccctgcta ccaccacaca gatttcttcg tggaacatcc 254760 

cttgtttgtg aagcattgac acttatgcaa aaaggtatta aaagtaagtg tctggcaggg 254820 

cacggtggct cacgcctgta attccaagca ctttgggata tggatcacaa ggtcaggaga 254880 

tcaagaccat gctggctaac acggtgaaac cctctctcta ctaaaaatac aaaaaattag 254940 

ccaggcgcgg tggtaagcac ctatagtccc agctgctcgg gaggctgagg caggagaatc 255000 

gcttgaaccc aggaggcaga ggttgcagtg agccgtgatc gcacaactgc actccagcct 255060 

ggatgacaga gcaagagtcc aactcaaaaa aaaaaaaata gtaaaggttt cctgccttta 255120 

tggacaacct gtttgtcaaa tatgatcaca ttccataaat tagttttaag ttcaactggg 255180 

gtttccctcc tttcagcatg catattatct cttcccttcc tctggacctt tcctatccat 255240 

gtctttacta ggattattac atgtctggtg agtgctgtaa acaaaatgtt atgtgtgcaa 255300 

ttaatgctaa tttggatgat aggaaacaga aatattaatt ctaattactt ttcaaacata 255360 

gctcatgcaa taataagaga atctgatgtc actgcaagac gatttggttg agatgataat 255420 

gctaatttat tgaaatgggt gggtgtcata atcagtttga aaaaaagaga aacatttcta 255480 

agacatacca gatcatatta atacatcacc gccacacaca aaattggtgt taacatacaa 255540 

attcctctgg acgtttaaga agcaatgcct ccttaaatat tgagatctag tgaatgcacc 255600 

ttttcaaatt gtaatatata ggtcagaggg ttttttgttt gttttgtttt cctatctttc 255660 

tatttggctt ttctctttac atagactaga gaaataaagg cacatgcaaa tgcatagatt 255720 

tatttattta gatttcaatt gaaatttttc attatgttta ttatttgtaa acacaggcat 255780 

ctgcttggct tcatgtgcaa agccctgaat tcattctctt cttactgaag ttcttgaaat 255840 

gaaagtaata ctttaatatt tgataataat agcccaagaa ggatggtaac atccaattgt 255900 

aagtattaca tgtcgaagaa taaatttttt acaggaaaat gcattatatt aagaatcata 255960 

gaagttttta ctcataataa caaatatgga agaaaaaata gcttgcgata aacataccca 256020 

gtccatattt gtatccaaca tatatttttt ctctaaagca gaattacaat ataaaaacaa 256080 

aatttagatt ccaaatggta tgtcatatta gagagaaaaa tagtgcaaat gaacagttta 256140 

aaactgtcca aaaatatgag taattttatt tgaaaaatga caagcattct tcagagttct 256200 

gggccaccca attatttcaa taagacaaat tgtcttggag aatggctcat aaactctgag 256260 

ccattcatta gtttattttt gtatcatcag ggagttagct tgggaaactg gcaaaatcct 256320 

atctggcttg aaaagtaaat gcccttggat tagggttctg tgcaacaaaa attgcaaaag 256380 

gctaataatt ttacttaaaa attttatgat tattaatttt cattctgtca gcctacatca 256440 

caattaaaag aaataaatca ttttggcggt ttgtgcctga tttttcccaa gtttctttgt 256500 

ttgtttgctt gttttaatat taagtatatt tctattagct ggcaacagct gttatttggg 256560 

tgcctcagct gactgctccc agaataccca cagcttcagt gtgtacactt tactacaaat 256620 

tcttgatgtc tggattacta aataattaaa accattcttg cacatgtcca atataagagg 256680 

gagtagataa acttcttgct tcataccttt ttccaaaagc ttttattttc aagtaaaatt 256740 

gattcttatt tgcttttaat ttaccagcca caaccctaat atcatttaac tagctagtta 256800 

ataaagcctt ataattaaag cttcgtatta aatctttgta tacacaatga tttatttggg 256860 

acttaaattt tgaattcttt cctccttaaa ttaataaaat tttgagtttc tgttttaatc 256920 

ttcaaatatt tcaattattt gttttttaaa caaacaagcc tgaactaaag gaatgattga 256980 

aattcataaa tgccattttt tctcttacat gatcatacta ttaaaactat aaagtttaca 257040 

catcaaaata agaagataac taaagacaaa ataaaaaatt gtgaaagcac caagaaataa 257100 

atgacacctt acctatcagg ggaaaaatct tatggactct ccataagaaa gagtagtaac 257160 

tcctccaaga tccctgaagg ataataatct gtgacactac agtagatact cagacataaa 257220 

gtagttccaa gaacaaagac tattgtctgt caagagctgc ttattttctt attttcatga 257280 

cagccagaaa tacattgaaa aggtatattt gtaatacatt agccacagtc taattgtgct 257340 

accactggag agctgctcag tgtctagttc atcacacaat aggggatgga agttgaattc 257400 

attctttttg aaggtttgta tggtctgact gtgtcctcac ccaaatctcc tctccaactc 257460 

ctacatgttg taggaggaac ccagtgggag gcaattgaat catgggggca agtctttcct 257520 

atgctgttct catgatagta agtctcatga gatctgatgg ttttaaaaac aagagttccc 257580 

tgcacaagct ctctttgcct gctgccatcc atgtaaaatg tgacttgttc ctccttacct 257640 

tctgccatga ttgtaaggct tccccagcca cgtggaactg taagtccagt aaacctcttt 257700 

attttgtaaa ttgcccagtc tcggggatgt ctttaacagc agcgtgaaag cggacaatac 257760 

aaaggtctaa tcagagttgg atttgtgttg cttttgtttg taacactctg ctaagactga 257820 

acacaaggag gtccaatttt ttccatgtca ctagcttttt cacctctttt ccacagtagc 257880 

ataaattcat gctaggaagt taactgtgtg ggcatgagag cttgtctata ccatgatctc 257940 

caaaaaactg attttaattc tttttacctt tcctaccaat atacttgcca ttgctttcct 258000 

cttcaaacct caactattta gtcagtggat tcagctttaa tcttgtcacc ttatatgtac 258060 

acagacattt ttacatgttt tacgtgaaac aagatagagc atgagtaagt aaataagtgt 258120 

gtgtgtatga tgcacatgtg tgtgcagaaa aatgtaatct caatttatta ttattatcta 258180 

gtgcaattag agagatggtc aagcacaggt aacaaaaggg tttaacagaa aactgataac 258240 

gtatgtcttt agggaagaaa ggattacaaa tttcacgctg gtcaaaattg aaatttcata 258300 

gaataaacat ctgcagttta tgctaaaatc tgcatgtagg gttaaaatat gatattatta 258360 

taggtagatt tcaacctttg gttgcagctg gctgaggggg ctgctggcaa cagctgttat 258420 

ttgggtgccc cagctgactg ctcccagaat acccatagca gttacatgct gggaggagaa 258480 

ggaggcaggt gctatcagat gactcctcag gaatgtgccc taaagggaac actatttagc 258540 

atacaggaga cttgtcatgt gactttcttt ggagggtgat tttaaagact tgtctgcaac 258600 

taatgatgtc tgtgatctgt acagaggtca ccttcaataa cttctcttcc tgtaaacagg 258660 

aaaaggaatg ctgaaaaatg ggtaagagag gaaaacaaca gggagcccca gtcacttctg 258720 

gacctagtag ccaatgtgac actgtttgct atccctggag ctgagtttta gtaatcctta 258780 

gatattttca gtttactttg tttagaaatt gaacttcaac acaatgaaca ctagtgaggt 258840 

tggatgttgc agccaaaaag cttaggattt gaaggaatcc tatgaatcca tcttcactac 258900 

ttcacagctt tgtgacactg gtttcatcat ataacttacc tacatgttat tatcccagtt 258960 

tgtaaaatgg tgattataat aactgcctca atacattaat ataaagatga aatgaggaaa 259020 

catgtaaggt gcctggcata tattagatgc tcaatattta tggttccttt ttcatcatgt 259080 

tgtaggctaa ttgaacccaa tctttcaacc ctcagagact gagttgggta ttagaagaca 259140 

ttcacatgtt tatgctagga atcaattcac tccatccaca ttggccatcc ttgttgctcc 259200 

ttaaacatgg taggcattct tctaccttag ggcaatggat ctggctattc cctcctctgg 259260 

accttctccc aagtatgcat acaaactgac tcacttcctt caactcttca cttaaatgta 259320 

ttcttctcat caaggtttac cctgacaacc ccacttaata ctgtaaactg tacatggccc 259380 

tcttcactgc tccctcagtg ccatactcct gagtcccctt accatgctcc tttgtttttt 259440 

tttttttaaa tacatttatt gccttctagc acttagtaaa attttaaaat tatatttact 259500 

gtttattctt tgtttttccc cagtagactg ttgtattagt ccattttcat gctgctgata 259560 

aagacatacc caaggctggg aagaaaaaga ggttcaattg gatatacagt tccacatggc 259620 

tggggaggcc tcagaatcat ggcaggaggt gaaaggcact tattacatgt aggtggcgag 259680 

aaaaagatga gaaggatgca aaagcagaaa cccctgataa aaccgtcaga tcctgtgaga 259740 

cctactcact gccatgagaa cagtatgagg gaaaacaccc ccaaaattca aatgatctct 259800 

caccgggtac ctaccacaaa acatgggaat tatgcaagta aaattcaaga tgagatttgg 259860 

gtggggacag agagcgaaac aatatcattc tctccctggc ccctccaaat cttatgtcct 259920 

caagtttcaa aaccaatcat gccttcccaa cagtccgcca aactcttaac tcatttcagc 259980 

attaacccaa aagtccacag tccaaagtct catctgagac aaggcaagtc ccttccgcct 260040 

acaagcctgt aaaatcaaaa acaagctagt tacttcctag atacaataga ggtacaggta 260100 

ttgggtaaat acagtcattc taaatgggag aaattggcca aaacaaaggt gttacagggc 260160 

ccatgcaagt ccaaaatcca gtggggcagt caaattctaa agctccaaaa tgatctcctt 260220 

tgactccatg tctcacatct aggtcatgct gatgcaagaa gtagattctt atagtcttgg 260280 

ccagctctgc ctcagtggct ttgcagggta tagaccctct tctggctttt ttcacgggca 260340 

gctggagttg agtgtctgtg gtttttccag gcacacagtg caagctgtca ttggatctac 260400 

cattctgggg tctggaggac agtggccctc ttctcacagc ctcactaggc agtgccccag 260460 

tagggactct gtgtgggggc tctgacacca catttccctt ctgccctgcc ctagcagaag 260520 

ttctccatga gggccccacc cctgcagcaa acttttgcct gggcatccag gcatttccat 260580 

atatcttctg aaatctaggt ggacgttccc aaacctcagt tcttgacttc tgtgcacctg 260640 

caggctcaac atcagatgga agctgccaag gtttgggggc tcgcaccctc tgaaaccatg 260700 

ggccaagcta taccctggcc ccttttagca atggctagag tgtcttggat gcagggcacc 260760 

aagtccctag gctgcacaca gcacagggac cctgggcttg gctcacaaaa ccatttttac 260820 

ctcccaggct tctggatctg tgatgggagg ggctgctgtg aagacctatg acatgccctg 260880 

gagatatttt ccacattgtc atagggatta acattcagct ccttgttact tatgtaaatt 260940 

tctgcagaca ggtttaattt ctcctcaaag aaatgggttt ttcttttcta ctgtatcatc 261000 

agactgcaaa ttttctgaag ttttatgctc tgtttccttt taaagtggaa agcttttaac 261060 

agcacccagg tcacttccta aattctttgc tgcttagaaa tttcttccaa cagatacctt 261120 

aaatcatctc tctctagttc aaagttccac tgatctctaa ggcaggggca aaatgctgcc 261180 

agtctctttg ctaaaacata acaagagtca tctttgctcc agttcccaac aagttcctca 261240 

tctccatctg agatcacctc agcctagacc ttatcattca tatcactatc agcatttttg 261300 

tcaaagtcat tcaacaagtc tctaggaagt tccaaacttt cccacttttt cctgtcttct 261360 

tctgagccct ccaaattgtt tcaacctctg cctgataccc agttccaaag ttgcttccac 261420 

atttttgggt atcttttcag caatgcccca ttctactggt accaatttac tgtattagtc 261480 

tgttttcatg ctgctgatga agacatatgc aagactagga agaaaaagag gttcaattgg 261540 

acttgtagtt ccacatgtct ggggaggcct cagaatcata gcaggatgtg aaaggcactt 261600 

cttacatggc agcagcaaga aaaaaattag gaggatacaa aagcagaaac ctctgataaa 261660 

accatcagat ctcgcgagat ttattcacta acatgagaac agtgtggggg aaacaacccc 261720 

catgactcaa attatctacc actgggtcct tcccacaaca catgggaatt atgggagtac 261780 

aattcaagat gagatttagg tggtgacaca gagccaaacc gtatcaactg tatactccat 261840 

aagggtttaa aatctttatt cacttcactg atgtatatca tgcacctgtt tccttgtaga 261900 

tagggcagaa taaatatttt ttcatgaatg aatgcactga ggcacttcag aatacatcaa 261960 

tctacagtgt ttaggaattg actatgacct gaattaatat gctttgttca cctcacatcc 262020 

ccagatcctg gagtgtagta agtacgacat gtatagtaga atgaataaaa aataatggat 262080 

tcaggcacaa cacagcttcc tatgaggcta gggaattacc cagactcagg caaaattcat 262140 

tactatcatt ctcctcttta tgaacctgac aaccaaacat aatggcttag gaattttttc 262200 

tgttaaatat atttgattga tattatatac ccagaaggtc aagataatgt ggaaaatatt 262260 

atctactgcc cttgagtcaa ggactctgat gtatatcgtg gtgaatattt atgcttacta 262320 

tgtcatttca agtttgaatg ttgacattta aattaaaata atgtccctca tttttgtaac 262380 

acaagagcaa tagaaaggtc agttgtacct taccagtgga tagtactaca ttgctcccgt 262440 

gtcattttga gctttgctga gcaggagact ggcttctaat ctcatggagt gatcctatgt 262500 

acatcaccca gttgaagaaa cacaactgat taggcctttc ctaaaaagct attctttgtt 262560 

cttgaaagtt tctgctctac atagtagcaa gatggcatta tctagtacaa ccttaagaaa 262620 

acacaccctc tcaacactca agatgaaaat gctcagagga tttgtataga gtcaaatcca 262680 

aagtgaaaaa ttactttata gttgtgttat tgggaggagt ggtggcaata agacataaaa 262740 

taaggagggg taaatgttat gaaaacaaga tagaaagttt atggtaatca tagtaaattt 262800 

ctgtcaagag agctgcaatt cagatatgct ccattctcac ttgaccttta tttacctcta 262860 

ctcccagtca ttaaaatgat ggtctttctc ctgagatagt tctataatgg atactttggg 262920 

acatattaat ctgatttcac acaattgctg tgctcagtca tctgtactca atgtgtcata 262980 

tatgcctgaa caaccagaca tcatacaaag gctttatgtg atgctagtat gtgatcttgc 263040 

cttataacaa cgcatttatc acttaaatgt gcctttgtct tttctcctgg aattaagaca 263100 

gctaaagatt tcacaagttg cacctaagaa tgatacccca ggaaagcact ggacctgttt 263160 

atattccacc tcatcaagaa cacagtcatt cacttatttg atcacacagg gtaaaggaga 263220 

tatgcaacac ttttctgaaa ccatgtgaag agaggagaat aaatcaagca ttctggtaaa 263280 

caattcatgc catcaaaaac atgttttaat gtgtgcaact gtctttaagt gctccaaacc 263340 

cagacatctt actttacagt cagagctccc aagtggcaaa caaaagcacc aacttgctca 263400 

tgattcattc taatcttttt acataaaact ggaactagga accatagtca aggaataaga 263460 

aagctgatcc agaatctacc actataaatt attcagctaa aaaaattaca taaatgcatg 263520 

cagaagtcag gaagaagaaa tcaaaacata agatcataat cccagtagta tgctgttaaa 263580 

acatgaatga acaaagattg ttggttctat gtagagatac tgtattgaat ggaagacgtg 263640 

aaaagctgtc ggctcccaag actctgatga cataagtatc aaagaatgag aaatggactg 263700 

gatgattagt gctaaaagga acttttaagg acatctaatg caaacccagt aattttacag 263760 

aggctttaaa tagatttgga gaagttgaat aatgtgctct caatccataa ttagttgata 263820 

ctggtgaata taccagaaaa acagaacaaa ccatctttgc cattaaagtg tatctgtctt 263880 

attaggttta actaatatag tcagacatca ggtcatgtga taccaaatgc ttgaactggt 263940 

caggtgttgc actttttgtt cccagaattg atagatggtt gttattccat tctgccattg 264000 

cctttgtttg ttatcatagt aattataatg ccctatttac ttcagctaga ggattaatgt 264060 

ttccggatat cttttcttct gcctagacat agattatttg tataaatact ctataaaatg 264120 

gagttcccag gttttgttcc tattcagtta ttctactttc tatcttgcaa ttaactacaa 264180 

agaggtgaat acatagcact gagaatgagg caaaccaagg gcctgccatc aggtgatttt 264240 

aaacattgaa cattggcaca gcaattaaac tcaaccaact gtagagttaa taaaaataca 264300 

gatccagatt gctagtcaac tatttcagat gcatggttct ggttacacag tgaaaactta 264360 

ggagccttaa ggacactata gaggttgctg cagccagttt agtcaacgcc ttacaaacca 264420 

ttacagctga aagtgctgag aatgatctag tagacaattc tcactcaagg tcagaaagat 264480 

aactgatggc tggaccagaa tggataccaa gaatttctca cacgagacca ggaatctctc 264540 

caaacaactc ttaccttgag gataatgtaa cttcgaaaga aatttgtaca tatttttctt 264600 

agttctgtgg aatatttaaa tggtcccaca taatttcaaa taaattctgg ttgaagtttc 264660 

gtggatcttg gtttttttca atctacaagt tatttacaag ttttaaaact actgagttag 264720 

gttttctttt ctttgtttat ttaagaaaag ggaggacaaa tagcccgaaa cttcaagctg 264780 

ttcatgctga ggaattggac attatatatt aaggacacaa gaggtatgag aattcctcag 264840 

ctacagtcgg cagcaaatgt gttcgacaag ctgaaaggtt tagcactaag tacaaggcaa 264900 

gagagataga agataaggaa ggaaagctaa ggaaataaat ttttcttaca aaactcctct 264960 

aaagtattct ttttataaca ggtcttgcca gaacttagat aagccagaat gactacgtta 265020 

ttcttccaga aaactgttta tgaatcagtc tgctattttc tacccaaaaa aaaaaaaaaa 265080 

aaaaaaaaat cacagtactt cagcactgag gggattagtg gctgagcaat ctccttcaga 265140 

gtgctgctca cttaatttgt taaaggacaa agtagttgaa tcatcttact tgctgaatct 265200 

acaggaaaaa tactgtcact tctttattgt tgtcattttc cagtgtttat tatgtcataa 265260 

aatgttaggc tttgaagtcc caatctgact gtttagagca gggatctcct gccaactgca 265320 

ttatgtcatc aaatgagcaa acataataaa cataattaac atagcaagca tttttcaagt 265380 

cactggaatt taaaagttgt ttgttatagc tactggtgtt acttaccctg acttatgcac 265440 

aaaggaaaat agtttcattt caaataggta gttttttccc aaatagctat acatattttt 265500 

taccaatatt ttattctcct cttctgtata cctagaggat gtgattattg tcttccatga 265560 

aactgaataa agtattgtga ctagatctag ccaataaatt gtaaatgaaa attattaggt 265620 

tggtgcaaaa gtaattgtgg tttttttcca ttacttttaa tatgtgtggc tgtgattgtg 265680 

gatatcgtgt gttcaattat ccaggctttc ttttggtgat cgagacagtt tcatgttcta 265740 

aatgttgcag ctaccacata gtaaagcccc tgttggcctg ggtttctgag tgactctaga 265800 

gttgagtccc atgtcaacca aaaatagtta cacaatttga gtagaaaata aggttatatt 265860 

gtgttaagct gctgagattt tcagttggtt atcatagtac aacttaccct acacaatata 265920 

tatgactcat gggataaaaa atatatatgt atatatttgc atatgtgtgt atatttgtat 265980 

ataagcatct atgtgtatgt gtatatatgt acatatatgt atatgcatgt gtatatgcat 266040 

acatagtaca tatatacaca cataagttta tctatgtgta tgtacataga cacataaata 266100 

catataaaag tttattagtc agaatatgca tgtatataca tgtgcataca tgcacatgta 266160 

tatataatat ggttactaaa ttgttgcata aagaattctg ataatatatt agtgctttat 266220 

tttacagaaa cgtttcttaa ttatgtcttt aaaagaaaac agttttcaac aatttaggtt 266280 

accttttata acattatacc aaaacgcaag caaaccatag cctagatggc aatctctgct 266340 

aaaggttctg caggtgctaa ttatacccct tgatcttttt acattttaac tagtatgaaa 266400 

ataaatacga aaaatatgtg gaattgtgag tctcaaaata ttagcttttc accctaaacc 266460 

tctgtactac ctaatatgaa ctgactcatc cttctactta cagggagagc cgctggagga 266520 

ctgtgggctt ccctttgcag agctaaaaat gctcttctct agtgagttta ctgcacagag 266580 

gagtaagcag aggaaagcag gcactgcttt aggacatgtt ggagagggag caagagtctg 266640 

ctgtcttgca ccacaatgat actcacctca tctcatcctt aggagaagta gaaaacaggg 266700 

caattgggaa gacagactcc tggggttctt ccaacattgt ttcctcttgg aaagactcag 266760 

aaattctttt ttagctatga aattttaaga agttgattaa tatgctttct cttccacccg 266820 

caacaacctt gtatgagtct tccacatctt tgccattatt accattcaac attaaatgct 266880 

gtgtcctctg actgaagaga catgatgact aggtgtatgt ggtgttctca attggatact 266940 

gaaacagaaa aagaacacga gtagaaaaac agacaaaatt ttaacaaagt ccgaagctta 267000 

gttgatagga atgtactgat gttaatttct tagttttgat aaatatacca tgcttatata 267060 

aaatgttaac atttggggac actggatgaa gggtatgtaa aaactctgta ctacttttgc 267120 

aactcttctg taaatctaaa attatttcaa aacaaaagtt taaaagaaaa atattttgtt 267180 

ttacaggatg gggagcacaa tcattagaaa tttatcttgt gagtagaaaa ttcatggcaa 267240 

agcctgccta aaggcaaagt gaattaggtg ggatgaacct aaagagatat tttggggctc 267300 

ctcttttaat attctaattt aagcataata ataatacgct tcttgtaatg ctctgtgact 267360 

ttgaatagaa tgggaggcag gtttgcccta agcaatatcc agctcgagtt ttccttagtg 267420 

attttggagg tccaagatat tttcctttca caggtcaatg aataagaaaa ggagcaaata 267480 

cattaaaaag ctgacctacc gtatgcggct gacttctcat aattttgtga atcctaaaag 267540 

gtattctttc ttactttgtt ctcagcttcc tttcatctga gaaagttctt aaatacctag 267600 

tatccaagaa tcttatctac ccttctcaac tcctagatga aggggggatc ttaaaagttt 267660 

cttcctcacc attccttgaa gggggttcta tagacatatg gagttaccct ggctggatga 267720 

agccaccctg caattaacct cagtgttcat gtaatagata tgagtttgtc acttaatttc 267780 

aacagcaaac aacctcgtaa aagtcaacac agaagggaaa aaaatggtta ctagctttgg 267840 

aattagaaac aactagattt aaatagcaga tgtgtcactt tctagccagc ttctattaag 267900 

ccaaaaaatt tatcagattc tgagtcagtt tgtttgtctg taagactgta atagcctacc 267960 

tacaaggttg ttgtgagatt taaatgacac agcatatgta aaatagttcc tgggattaag 268020 

tagtgtatct caatatattg gttctacatt ctctgaaaaa agcagcgttt gattgtagga 268080 

tagcttgaaa gtgtgaccgt caagttggag ggaggggccg ggcgcggtgg ctcacgcctg 268140 

taatcccagc actttgggag gccgaggagg gcggatcacg aggtcaggag atcgagatca 268200 

tcctggctaa cacggtgaaa ccccgtctct accaaaaata caaaaaatta gccgggcgcg 268260 

gtggtgggcg cctgtagacc cagctactcg ggaggctgag gcaggagaat ggcacgaacc 268320 

cgggaggcgg gagcttgccg tgagccgaga tcaggccact acaccccagc ctgggcgaca 268380 

gagcaagact ctgtctcaaa aaaaaaaaaa aaaaaaattt ggagggagga agaaaatgtc 268440 

agtgcaagaa gtctaggcat acaactgcgt ggtggtttta ccgaaagata tgtacagtac 268500 

ttcacaatta tataaatgtt ggattatggt cacaggtata gcttaagcac ctttcaatct 268560 

attttcaccc tcatgccact gctcatggca tcatagaaag gtgtacaaga tgcatgccct 268620 

ggcagtatca agagtcattg aaagacacaa ctcagctgcc tctaaatggc aacttctttt 268680 

tatgttaatt gtataataaa gactatttag tcaaaatgag tttatcagtt gttactttaa 268740 

gactttcagt actcccattt ggaacagaac aaattttaaa ataagattga tacaaaatgg 268800 

tgttcatttg catgaataga aggtttttgc ccaaccagat caaagcacat tagtggattt 268860 

tgagctcaaa tttcaagcaa tttgcaactg tatacctgac aattcacaga ttagaaataa 268920 

ttttatgaac attgatcata gtggaaatag ctgtaataca aacaagagct cttagcaaaa 268980 

ggtttcaagg ccttataaaa ccaactaatc atgtaatgat tttttgttct gtttaattac 269040 

aagtcataat gcaatgtaat taaacccagt ggcaggagga taacagtacc aagatgcaga 269100 

caattaagtt aactacaaca tatgtaagat atatttatgt acccgataaa tcttctgaca 269160 

ggaaggatct agatctacct taattaaaat aagcattttt cttgcatttg cacataataa 269220 

aaagatacac agtttccata ttccaagcag taggataaac agtcaatgac tgatgtttaa 269280 

gaaacatgtt taaaaacctg aatttaagag tctaagaatg atttcttcta attcaggtgt 269340 

ttagagaaac cctgggtgaa ggggaaaaaa gtaatattgt ttggtaaaca taagtgtctc 269400 

ttttaaaaaa ttgatttgca gtttattaca cattctgggt aataattatt tgttatatat 269460 

atattgcaaa tatctactcc cagacctgta actgtttttt tacctttatc ttatcttttg 269520 

aaatacagat ttttacattt taattttgac atatttatca atctttctta catggcctgt 269580 

gcttttgtgc cttatttaaa aatacctttc caaccatata gtagcatata ttctcccaca 269640 

ttttctacta ataatttttt tgtagttaag ttttttattt ctctgatgtt aatttttgtg 269700 

ttttgggtga aattagggcc aatttcactg ttttaatgga aatccattaa ttccaacacc 269760 

attttcttac tttcttattt tgttcaactg agacaagcta gttatttttt tttcaccagc 269820 

accatttttt tttactgttt tataacatca tttctgtcaa atctttatat atttatgtac 269880 

gtattatggg attctctact ccattacata tctctattcc tatactaata tataactatt 269940 

ttaactttta taacattgta ataaatcttg gtatctagca gcccagccct cactcaaatg 270000 

agtcttgact tttcttactc attcagtcgt ccatattaat tttagaattc tcttctcatg 270060 

ttccatgaaa aataattgcc ttttttatga tattgagtct tccatataca tggcataaat 270120 

ctccatttat tcatattttt atatgacctt taataatatt ttttaattgc ccccacaaaa 270180 

ttcatgcaat tgttatattg atcaattcca atgaaattca taattttgga cactttttag 270240 

taggatattt tttctcgtat gttttctaat tggtcgaaga gcaggagtag gcatccttgt 270300 

ttttgacttc aatgagaatt tttctaaata gtaacaaata ttaaaaaatg tttaaccagt 270360 

agactgcaag ctccatgaca acaaggtctt gattcttttt attgctatat cacaatgctt 270420 

aagacaagta tctgataaat gtggatataa aataaatatt tataatctga ataaataaag 270480 

atatgatgca ggtttttttg gtagaaatct tttaactttg taatcaagtt ttcttctttt 270540 

gccagttgtg ttttaaaaat catgaactac tgttgaattt tgtaatttat tctttatata 270600 

ctgatataat tgtatgagtt tttgtccaat aattgctatt gttttgaact ggtgacttcc 270660 

ctaatatata actatcttta ctagtgataa ggtattacat ttttgtatat tgtagaattt 270720 

gttttgctga tattttaata tatttccatc tctttcaaaa gtgatattgc tctatgcttt 270780 

tgttgagtct gattatgtgt cttttctaga caatatgtag taagaccatg ttttattaat 270840 

tcattttgcc aacttctgct tttgactaga gtgtttaatt cctttacatt taatataatt 270900 

actgataagg taggatttat atctgccatt ttactttttt tctatatatc ttataccttt 270960 

cttgttcttc taatcttctg ttctgccctt cttttgtgtt aaatagatat tttccacttt 271020 

acctgtatta gtccgttttc acactgctga taaagacata ctcaagactg ggcaatttac 271080 

aaaagaaaga ggtttaattg ggctttcagt tatacgtggc tggggaaggt tcacaatcat 271140 

ggcataaggc aaggaggagc aagtcacatc ttacatggat ggcagcaagc aaagagaggt 271200 

gtgcaggaaa actccccctt ttaataacca tcagatctca tgagacttat tcactatcac 271260 

aagaacagca tgagaaagac ctgcccccat gattcaatta cctcccacca ggtacctcct 271320 

acaacatatg ggaattaaag atgagatttg ggtggggaca cagagccaaa ccatatcatt 271380 

tggccctggc ccctctcaaa tctcatgtcc tctcaaaacc aatcatgcct tcccaacagt 271440 

cccccaaagt cttaactcat ttcagaatta actcaaaagt ccacagtcca aagtctcatc 271500 

tgagacaagg caagtccctt ccatctatga gcctgtaaaa tcaaaagcaa gttagttact 271560 

tcctagatac aatgcgggta caggcattgg ataaatacag ctattgcaaa tgggagatat 271620 

tggccaaaaa aagggggcta caggtaccat gcaagtccaa aatccagcag ggcagtcaaa 271680 

tcttaaagct cctaaatgat ttcctttgac tccatgcctt acatccagat cacactgatg 271740 

caagaggtgg gttcccatgg tcttgggcag ctctgccctg tggctttgct gggtatacct 271800 

ccactcctgg ctgctttcat gggctgacat tgagtgtctg tggcttttct aggtgcatgg 271860 

tgcaagccgt cagtggacct accattctag ggtctggagg atggtggtcc tcttctcaca 271920 

gctccattag gcagtgcccc agtagggact ctgtgtgggg gctccaaccc cacattaccc 271980 

ttttgcactg tcctagcaga gatccatgag ggccgtgccc cagcagcaaa ctttgtctgg 272040 

gcatcaaggc atttccatac atctgatatc taggttccca aacctcaatt cttgacttct 272100 

gtgcacctgc aggctcaatg tcacatgtaa gcatccaaaa ctaagggtgt ctaccctctg 272160 

aagcaatagt ccaagctgta ccttgccccc ttttaatcat ggctggagtg gctgggaccc 272220 

agggcaccaa gttcctagac tgcacacagc acagggacct tgggcgcacg aaatcatttt 272280 

ctcttaggtc accacactca tgcctgtgct ttgaaggggc tgctgtgaaa acctctgaca 272340 

tgccctggat acattttccc attgtcttgg ggattaacat ttggctcctt attacttatg 272400 

caaatttctg caagcagctt gaatttctcc tcagaaaatg gatttcccca ttgtcttggt 272460 

gattaacatt tggctcctta ttacttatgc aaatttctgc aagcagcttg aatttctcct 272520 

cagaaaatgc attttccttt ctattacatt gtcaggctgc aaattttctg aacttttatg 272580 

ctctgcttcc cttataaaac tgaatgcctt taacagtacc caagtcacct ttagaatgct 272640 

ttgctgctta gaaatttctt ccatcagata ccctaaacca tctctcaagt tcaaagttcc 272700 

ccaaatctct aaggcagggg caaaatgctg ccagtctctt tgctaaaaca taacaagggt 272760 

cacctttgct ccagttccca acaagtcact catcttcatc tgagaccact tcagcctgga 272820 

ctttattgtc catatggcta tcaggctttt agtcaaagcc attcaataag tttctaagga 272880 

gttccaaact ttcccatatt ttcctgcgtt tttctgaacc ctccaaactg ttccaacttc 272940 

tgcctgttac ccagttccaa agttgcttcc acattttcag gtgtcttttc accagcttcc 273000 

cacactactg gtagcaattt tctgtattag tctgttttta tgctgctgat aaagacatac 273060 

ccaagactgg gcaacttaca aaagaaagag gtttaattgg atttatgttc cacatggctg 273120 

gggaagcctc agaatcatgg tggaaggcaa ggaggaggaa gttatgtctt acgtggatgg 273180 

cagcaagcaa agagaacttg tgcaggaaaa ctccctctta taataaccat cagatctctt 273240 

gagacttact cacttttatg agaacagcat gggaaagacc tgcctccatg attcaactac 273300 

ctcccaccaa gtccctcaca caacatgtgg gaattcaaga tgagatttgg ttgaggacac 273360 

agccaaacca tatcagtact attttaattc tatcattgtt tctttaatta ttatatattt 273420 

ttgtgttatt ttctcagtgg ttgcctgggg actgcaatta gcatcttaat ttaaaacaac 273480 

atcatttgga ttagtaccaa cttaattgca atagtatatg aaaactttgg tccaatatgc 273540 

atccatttgt ttttgttctc tgtgttattg ttatgcaaat tatatcttta tatataatat 273600 

gcctttaaac atgttttata attattgtgt tatacagttg tctttttcac taccatattg 273660 

tttcctttat gagtactatt tctttcctca tgtggattca agttaatgtc tactatcatt 273720 

ttatttcagc ctaaaggact tcccttagta tttcttgtag gacaagtctg ctaacaacaa 273780 

catatcttag ttttcatttc tctgataatg ttttaattta ttgaaggata tttgaatata 273840 

gaattcttgg gtgatagtct ttttccttta gcagtttaaa tatatcatcc cactgtcctc 273900 

tgatcattat ggtttctgat ggaaatcagt tttaatctta ttgaggatcc cttgtatgtg 273960 

atatttccct ctgctgtttt caggattctt tgtctttcaa tagtttgatt ataacatgtc 274020 

tagaaacaga tctaattaag gttctcacct ttgaattttt aagcttcctg gatcaatgtt 274080 

tttcacccaa ttggatgaag atttcagcca ttaatttttc aaatattctt tctacccctt 274140 

tctctctcct tcttcttcag aaactccctt tgaatgtatg ttggtaagct tgatggtgtg 274200 

cacaggtctt tgttaattat tcttgattat cttttccctg taccccagac tgggccatct 274260 

caattgatct atcttcaatt ttacggtttc cttttttttg gaggggaggg tgctatctta 274320 

aatctgtttt tgagcttctc tactgagtat tttcttttaa ttactgtagt ttaaaacttt 274380 

atagatatat atataatatg tagtattgta tatataattt ctgtctcttt attgatattc 274440 

tctatttagt gagatattct tatatcatac ttttcttttt taaaaataca tggcttcttt 274500 

tagttctttg agcatattta caatagatta tttgaagtct ttttctagta agtccaaatc 274560 

tggacttatt caagaacagt ttctactgac attttttttt ctatatatga gccatacttt 274620 

ctttgttgca tgtctctttt tttgggtgtc aactcaacat tttaaatatt attgagtaac 274680 

ttttgaaatt atattaacct tctttccagt gtttgttgtt ttggttaaat gctattttgg 274740 

ttatgattgc tgtggttgct gttttttctc tttgtttatt tagtaacttt tcttttctga 274800 

ttatgtaaat tctgagtttt ttggctgatt ataccactgg acttcagtaa attcttcagg 274860 

acagagacta tgttctgtac caacaatgcc tcagatagtt tctggccatg ttagaagctc 274920 

aatacatttt ttatgtaaaa gatgaacaaa tagtatcaat aacacttttc tctgatgtgg 274980 

ataatgagga gatggaaata atagtataca atttgggtat tgccatttat gtggtactta 275040 

ctactaattg acacatacac tataatgatt ttaaatacaa acactgagtt atgatttagt 275100 

aatgttttaa ttttgaattt tcttattctg ctttaataaa atgttggact atcatcattt 275160 

aatatttgaa agctgaagtt tttatgcagc tttcggtcac tagcagttaa aatgcccctt 275220 

gcaatttttc tctatttgct tttaaaatta aaccaattta aatcgtatct atggaatacc 275280 

tgttactccc aaaagggctt gaaagtctca acattttctg ttattcgcac ttggagaaat 275340 

gaatttctgt tgcatgtagc tagcatcgac tgccacaaga gaggtaatgg ccattggata 275400 

tacattcaca tctctgacag accttctagg acaaggagtt accaattaga ggtttctcag 275460 

gaagctttta ccccaacagc taattgataa aagagaccgt ggtttcccta gtaatagctg 275520 

tagacttttg aaattgaacc agacttacac ctctgcagca gatataccag cttattaaat 275580 

aggtgatata gtttgaagaa tcaaaaactt ttttaaaaat ctgaatattt acctttttca 275640 

agtgaaaata ttgaaagttt ttaacagcct ctgagcaaac aaaagttatc ataaaatcta 275700 

gcatgtaatg tgtccaatat attgaagtgt gtcatttatt ctggactaag tcaaggtaca 275760 

cataaatgta tacatatacc atgagaaagg cagataactg tggtacagca gaaacaattg 275820 

gatataactc atgaatgaga agtcagagtt atcagcctgg aggggagcta gaataactat 275880 

gaatgcttag ctgtaaataa cacaaagaag acaatcattt gaaggagttt caaatttgcg 275940 

aagctgatgt gaagtggaga acaaattatt ttttcattaa tccagtctga taccttgtgt 276000 

gatattgaca agtgcttctg cattctatgt taatttaata aagtcatctt gaagaatctg 276060 

cactatttac aacactcaag attcccctta atccttagat cctcataaat gtggcttttg 276120 

catcctctgc ttatttacga ttagatgtaa cattacaaat ttaaaattta tctttctccc 276180 

tcagaaagaa atagaagtca cagatatcag cattccctac acttgccagc cacatgggag 276240 

ctctggagta aagaagggac aacacaactc agaaagcaat tgctttgctg aaagagctga 276300 

ctataggtta aggcacagct cagcaatgag aaaaagaata aaaattatgt ttttgtattc 276360 

actgttgtct agtcctgaaa attaaaaccc atttccattc ttattttcta aatagtattt 276420 

caaagttttg attctcataa aaaggaaata ttataaatct ttaattgtat taatgaataa 276480 

tgaatgatta tattccaatt aacactaaat catcaagttt ttcatgtcat tattagtgcc 276540 

aacatacttg agataattac aagtttacct tcagacaatg tggtttttat tgcatcacat 276600 

aaataatctg gtctcatccc caccaactcc ctacaacaaa ataaattcct aaaaagctga 276660 

aattcccact tatcaaagtc tctctttatg aagcaaacat tgatgtacct agaagtttct 276720 

tgttcaaata tcaatagact gaaagccgag tatatcaaga cttagaaatc tttaacactt 276780 

tagtgtggat agctcatcag tgtctttttt ttcttccaag aaactgggaa gagaaaattc 276840 

tgaggttcat aagtgtcctg agcagttaga gtttcaccaa ataactcaca atcaactgtt 276900 

aactagtagc agttcagagg gagtgagaca gactggaaag acattcttga tgaagtagaa 276960 

gagggagaga taggtccata gcttctcaca cacactaacc tctaggtttt tacaccttct 277020 

cctctactga aactctctac tcctctgtcc caaccccacc tctctacctg gctaattccc 277080 

tcacctttgg gtcttagtat aattatcatt tcctcaggca agggttctct ggctcctaag 277140 

attaggatgc tctcaaaggg tacttaaaat ctctggtttt gcctatatca aacaccaatt 277200 

aattctctat ctaattatgt tttaatatca tctttccaac tgcactgtaa gaaacaccat 277260 

gacagagcca cagctgtttt actcatgatt ctttcccagc ccctgaaaca aagtaataac 277320 

ctaaaaatat ctatggactg actgttgggt gcaatgcaaa tgcatgcagt aagcttggca 277380 

gcaagttctg catggcaaga cagggataga aatctgggtg gttgtgtaag ccttggaagg 277440 

tcatgattag gaatggaagg gaaagagaag agaaaaggag agaatatttt caacttcaca 277500 

atttgcctaa actttgttca tgctatttct tattggcccc cactttttct atttcttgcg 277560 

gcctcctctt tgtgtgtttt ggtaggaaca atgctaaaat tatataaaaa cttatgtagt 277620 

gctcgccagg tgccaagcac tgttctaaat gctgcacata ttaactcatt tggtcataat 277680 

agtagccctt atagaaaaat aactttgtta tctccatttg cagttgagga aactgaagcg 277740 

ttgagagggt aagtaatttc ccaaattcac acagatagaa tattgtagac ctagggttgg 277800 

aactcagcac tctgacttta gaatgcatgc tcctttaaga ccatcctggc taacaccgtg 277860 

aaaccccgtc tctactaaaa atgcaaaata ttagccaggc atggtggagg gcgcctgtag 277920 

tcctagctac ttgggaggct gaggcaggag aatggcttga acccgggacg cggagcttgc 277980 

agtgagccga gatcgcgcca ctgcactcca gcctgggcga cagagcgaga ctccgtctca 278040 

aaaaaaaaaa aaaaagaatg catgctctta aatgctttgc taaggttatg tggaaagata 278100 

gtgtcgatga catccctgct taattaacat ctgtttccaa acttcttttc ccttgcccat 278160 

atcctttata ggaaaagtta aatttgattc tttcccagtc tcttgcatct agtggtggct 278220 

gttcatgcca gttctgatac atatggcaca agtagatgtc ttttgaagag agaatacttc 278280 

tgggaaagca attgcttttc tgaaaacata ataggataaa tgtgggtggt gccatatttt 278340 

cctttgtttc ctgtctggaa tacagatatg aagcctggag ttctagtagc cattttgtat 278400 

ccatgaagga aaaccaaaga atcatagcag tcatagccga agccttgata atatagaggc 278460 

aatgaaccaa tgtcagcacc taacggtata acttgtcctt attacgtcat taaaaataaa 278520 

ctacagtttg cttattcact cttggtaatg ttttctgtta gttgtaattg aagacaagct 278580 

gaaattatac aagcaacaaa aaacattatc aagagtgata aacaaattga gatttctttt 278640 

ttaaattaac ttcctaacca aaagaatgga gacctaaggg acttctgaag caataccaaa 278700 

ttataatgat aatttgtaaa ggaaaatatt gtgaagggct agaattatac cacactatac 278760 

tagtcagaat ctcagcagag aatagatcaa acattcagaa ggcttaacgg aagacagtgt 278820 

aaataagatc atttatagag ggattgacag ggtcaaggaa actaacaatg gatggtgaaa 278880 

caccaagaat caagcaatga gcaggaagct gggcctgata aagctaacaa gggaaaagag 278940 

ttaccagagg ccagaaacac ctggatttgt gaaagcggct ttaccacaag ggagttttgt 279000 

atgtagaaat acttagtctc cggcagacca cagtagtcag ggctggagaa gggggtaggt 279060 

acgtaactac accaatactt atcccttctg actcctgcag gaggcctccc atgagtaagc 279120 

ccaattagaa gccagaggac aggagactct aggagatcta agtggtagag attggcctgc 279180 

tgggcactga gagggcagag aaggactgag aatagatctg gaggtgggaa agtgggtgga 279240 

agggatacaa atggagaata taatcaagct tgctctggca cagacagcaa atagacttcc 279300 

ttcttctctt tgtcttcttt tcttttacag atatcccaga aattagagta gaatatttga 279360 

taaaaataat aaaggtaatc agttctacct ccccccaccc acaaactgtg tgacctgggg 279420 

caagttacta gccactgtct caatgcatcc caagcatgct ccatatcctg gtggcttcag 279480 

tgtcctaaaa aatggctcat ctgatactct agttatttgc tttcttgatt gactcaatga 279540 

ccttcattca ctcccactca tgactacact ttggaccttg ttttcactgg gaaccgctcc 279600 

actattgaaa gtctaacaaa aataacccac aatcggcata caatgttgtg gtaggttgaa 279660 

taaagaaccc ccgtccccca aaatgttcac atcctaaacc ctggaaccta tattacctta 279720 

tacagcaaaa aaaaaaaaaa aaaaaaaaag ttgaagatat aattaagtta aggatgttga 279780 

gatagggaag tcatcgtgga ttatccaggt gggaccagta acataatgac aggcatcctt 279840 

ataagatagc tactactgca gaagaggaaa cagcaatgtg atgatggaag cacattggag 279900 

cgatgtagac accagaagtt agaagataaa agacagattc tccctggatc ccccagaagg 279960 

aactagccat ggagacacct tgattttagc cccgtaaact cttcaaactt ctagtctccc 280020 

aaactgtaag agaataaatt tctgttgttt taacccacta agtttgtagt aatttgctaa 280080 

agcggcgcta ggaacatgac acaaatgtcc tctcttttaa agctccccat actttcagta 280140 

actcagaaat gctcactggt gctttcactt tcccctagcc atgtgctgtt gtccttattc 280200 

catctctatc tgcaggctca cctgaacacg cctcccatca acatcatcat ttcccaagca 280260 

tcacccccct ctcctcacac ccactcagca gacaccaact ctggggtcag tccttgtacc 280320 

cgtcttctcc attcctacac ctggaattcc aagaacttct gaagaaaatg tcaccatctc 280380 

aggaaaaatc tatgttctcc acctagtttg ggatagcttt tttctctaat tttcgtaaac 280440 

atctatgtca gttctttacc actcttcttt atcccctcct ccaatctcct tctattatat 280500 

ctcagcaggt aacctcacct atttcagaaa actgaagaaa actgaaacca gtcatgaaaa 280560 

acaaggatat tttctttggt attttctttc taaataccta tttacattct tttccacctt 280620 

tacctctttt tgttcaaatt tctgtttcct gcctacgtgc ttagaagtta tatgaaaaga 280680 

tatacgcata aatgcagaga taaatataaa caaaagcaaa atgacagcag cagactatcc 280740 

ccaccaacag cagtagagaa ggcaaaagtc tggcacattt cttaaaaact gcactaactg 280800 

tagtaggctc tttggagtct aagattctat tgcaacctat tgggagaagc aaatatttaa 280860 

atgaatacat tataatacaa tgtgcaagtg taataggtga tgtgggtatg gatatgggag 280920 

aagcagagag gagggagtga gcaactctgc tagaatagtt aggaaaagaa gcccaacatt 280980 

ggccagaggc ttcatgggga ctactatgat ggaacaggac cttaaaggtg gagtgccaaa 281040 

gaaagtattc accaaagagg gaccagtaca tccaagagct ggaggcattg aaatgcatag 281100 

tgtttccagg gaagagtcag aggactggaa ttgctggaac attccactgg tgttaggaac 281160 

tggaaggaaa ggttctggag acatagtcgg ggccaggttc tgcaggctta ggctgagttt 281220 

caatattaat ttgaggctaa ttttcccaag ttgacctgat caaaagaatc acataaaaca 281280 

tttgttaaaa atatacattt tcaggacctt tctctaaaga tcctgactta agtataggat 281340 

taagtattgc ccccaggaat ctgtattgta atgaaatgta ggaacggaaa gaaggaaaaa 281400 

ttttagaaat aaattttaat tttaattttg ccacctatta aatataagat ccttagaaaa 281460 

acacataacc tccttgagtt tcacctttga aaagtggaaa atgacctcta ctttgcagaa 281520 

ctactatggg aagaagaagg gatgtaataa agtgcctggc atacagtaga gaggccaaag 281580 

taatagctat tactgttact tttgccatta ttatgtcccc tattgttcat gagttcaggt 281640 

cctctctttt tctggactat tatagtaact ttccaacaag tcttcttacc tccagtgtca 281700 

cctgaacaag cagcaagaga ctgtgcaggc acaggaaatt aaaggctggg atgaagcata 281760 

agaggtaggg gccaaaagaa agactgggca aaataagtca gacacagaaa gacaaaaact 281820 

gtatgatctc acttgtatgt ggaatttaaa actcagactt atagaagcag agtggttgac 281880 

aaggatttga ggggaagaga aaatgagttt ttggtcaaag gctacaaatt tgcagttata 281940 

aatacagtaa gttctgagga tctaatatat aacatggtga ccatagttaa taatactcta 282000 

ttgtttactt gaaatttgtt aagaaggcag attttaagtg tcttcaccct ccctccgaaa 282060 

aaaaacacaa acaatggtaa ctatggttag tgatagatgt gttaatttga ctatggtaat 282120 

taacactcac acagggttta catatatcaa atcgtcatgt tgcacacttt gaatatgtac 282180 

aatttttatt tgtcaattaa ttatttcaag aaagaaacaa acaaaagact aagctaagcc 282240 

atagctctca tatcaggcaa ccgaactctg aagaattcac atgtgcttct aagaacagtg 282300 

tcagaggaag agtgaaaacc aacagacagt atttcagatg tggagtttta aattgtacag 282360 

tactatggtt tacaaacaac caagaggtac agaaccttcc caaggtggtc ttcaggggaa 282420 

gaaaaggaga tttaatttag caccactgaa ggcagagatt ctgaaaaaaa cctaaaacca 282480 

ttttaggtgt atgccccttc aatttcagac tgttcaagaa tttggtaaga gggctgatgc 282540 

tatcaaagat gacatgcagg tctctggcct gggaaaatag gtgaatagca gtgctgtgac 282600 

atgaggtgga aatatagaag cccaggtctg ggcatagaga tttgtgagtt gaatggctga 282660 

aaatgttagt gaaagcatca ctggggatgt gatgacatgg gcagagtaga attaagggga 282720 

tccaagaaga aaatcgtagg aagtcttaca tttaagaggc agtcaaaaga aaagtagtca 282780 

atgaaggcac cagagaagag agagaataat acacaaaggg gagactatgg ctcgtgaacc 282840 

caatttcact tccacaattg tgccaagggc cagactagtt gagcaagctc tgcttttctc 282900 

attcccgcca ggaagacaaa gggttttgtg tttcaagaaa gttctgtgat gtgtactaaa 282960 

ggtaggcaat atacacttgt cattttcttt ggcttagaac tctagatagg ttcactggtc 283020 

tgtaaaacaa atgcccaaga aagaaaacac ataatgtatt gtttcctaca tgatttgggt 283080 

acatcaagca ccaattataa tacattgcct cttcatacac tgcactgacc ctagagtcat 283140 

aattctataa gccaggaaaa agggtagcta gaattaaaaa aatgcatttg tcatgagttc 283200 

taaaatgttt ttctcaattt gagaacgcca gattgtgaac tggtagacag atttagtgct 283260 

gtcttctaga tcacatgtcc ctctgtccaa ctcataggag aatgtaaata aaatatattc 283320 

aagatatatt tattgtgaac ataggtcagt tagagctaca gannnnnnnn nnnnnnnnnn 283380 

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 283440 

nnnnnnnnnn nnnnnnnnnn nncatgaaga caagtgtcca ggtgctgtgg gggccctggc 283500 

atgttagcaa gtgccctgca atggaggttc tgtcattggt gatggtaggt acataggtat 283560 

gtggtggtga ctgcaccatc tgatcattct tgtttcagca aattggctgt taagatctct 283620 

ctcaattcct gccaatccta atcctccatg cttcctagat ttctgtgagc tatgaatgct 283680 

ttctctacct aagttaacca gatctaatta tagacttttt tttttggtgc aacaaagggc 283740 

ccaaactagt acagcactac ttcagactta gtcttcctgg caatttgcct tcagggagct 283800 

agttctatag tgttttagaa taacatataa gacttgtggg atgggaagct tagtaaatat 283860 

ctatggtatc tgtttgccta gcatttcttt ccctgtgttt ctactaaggt acactcttac 283920 

tctggttttc ataaagacac atgacctaaa cttgatcaga caaaatattt tatcattact 283980 

ttgtgtcata gtgatataaa atgatataca cttacagggc gagtgtaacc taaggcttga 284040 

caatcagact tgagtctaga attgctttgt tgagagagat aggtaagggt aagaaagagt 284100 

ggtaggaagg aagagaagat gtagtagatg gtgttcatac ctcacccact tccttataaa 284160 

tctctttacc attttcatac acctgcatgt cttggttgga ggattgccct caggatgtca 284220 

gattcacttt gtacgtgcac atatttagct gaaagatctt agaaatttat gattccctgg 284280 

aagcagctct taactaatga ctaatatttg gttatcagga caaggctgag gggaaatctc 284340 

cattttggag tcctcctggg gaattgagcc aaggggattc acttgatttc acacctgtgc 284400 

accttagttt gtctgccttt ccttctctgg ccccatctct actccctcac cagattttcc 284460 

cagaaacact tcctaataaa ttcctttcaa ggtctgcttc taaataattt aatctaacat 284520 

accagagaag ccagaagtta tccctacttc cccgtggata acaatgcttg agaaaataaa 284580 

gccaacaagc agagagataa attgaatctg cttccgatca ctccagcctt tccaacagat 284640 

ggaatgataa attccctttt atacctaagc taaattgact ttgatttctg tcacttgcaa 284700 

tcaaaagata taattcatca gggtgatgca gagtgacccc tttccttgct taatccaaca 284760 

acaaatctca cagatatgat gtacatgata tcattgtgaa gggaaataaa tcagcaatgt 284820 

tttctgaaca aagttattag gaggccactg tcatatttac tgtgccttag atgccatgtg 284880 

cccaattcat gatttgtgat ttttgtacct ttcattagag cttattgtgc tgtttccaaa 284940 

cttttccaca gcataatcaa attaaaaaat tcagtctatc ttgatatatt ccatatcaca 285000 

tatcttgcct atgttaggaa agaaaaaaag aataaagagc aaaatctttc tgaaatgcaa 285060 

atatgatcat gtcagaccaa gtttaaggac cttcaatacc tcattcttgt cctcaagata 285120 

aggttcacac tccttaaaat agcctcaaaa ttcttcatta tgtggggtct gttgcaatct 285180 

ctgcccacag tcttcccatc caccccacat tctactcaca atgaaaactt ttcactcctt 285240 

gaatgacatg ctctttcttg gccctgaacc tttgtccttc ctctttctcc atatgcccac 285300 

accctcagat tctcaattca ctcagattat cacattttag gtttcagaac ttaactaagg 285360 

tgttacttct tccaggaagc cctctttgat gtcctgcctt cccccagatt cagattaagg 285420 

tttcctccta ggtgctccca gtattccctt tactttccta taattgtata tgtcaccttt 285480 

ttttgtgaat aaatagtgtt ccaattaaga atatatggcc tttgacagaa gattttgtct 285540 

gtctgtcgaa tgctatattt ctggagttta gcacagtgtc tgtctcacag agtcacaata 285600 

gtattgaatg aatgaatgaa tgaatgaatg agagatgttg aaagagaaga aataatatct 285660 

ttttgaacac cagcatagct ggtcattaaa ttccaagcag gaaacatctt cttagaggaa 285720 

atgtgctgat gggaaataga tgactacatc tattcctccc cagcatatgt ctccctgggt 285780 

atcatctctt tatgagagct aaagttaata accataaaat gtgtgctcag caacaagata 285840 

actcctgtga tttaacaaca ggaactacag tcatttagcc atgatacctg gcttccctcc 285900 

cagaataaga tacccaagtt ctcttaaaaa aaaaaagcaa ctaagtgtac ccacagctga 285960 

gagacttagg ttgatcactt aacctcttta ttgttatatt aatttatgga ttaatgtcca 286020 

gaggcagcta gctgtaaaga cttctcttca aaacaatttc atttttaaac ttgtctcatc 286080 

tagtagccag acagattaag gaataaggag actgatttat ggagcaaggt gtaagaatgg 286140 

aaatcagaag tttgtgaact atgaagaaaa ttgtaatata ttgtttctta gcaggagaaa 286200 

gactagacag cacctgtgta tcagattgaa gaacagcatt tattgagagg aaagttacca 286260 

tacacacaaa tggaaaacac acataacatg atgaccttca ccataaggta cagacagcca 286320 

cataaataga aggcactatc tatgtatgct cttttttatc tagtgaagta agacacttac 286380 

actctctcaa caagttgatt tgttttaagc tgtcaggttt gccctgacca ggatcactat 286440 

gctggatgtt atgtactcaa acaataggct aaccaatctc agaaatggaa gctacgacta 286500 

gtactgccct cctccgtgca gtatccttga ttgttttgct ggatatcagt catcatttct 286560 

taggagtatt aatcccaaat cagcataact gaggaaaaac atcaaaataa actttcttcc 286620 

aatcctcaaa aacttttatt agaaaagaat agaatgagga gaaaaagtat tacaagtctg 286680 

aggattgaca gtggcacgaa tcataatgca tgcttatgaa tgactgggta gaagaccagt 286740 

taggttgaac tgaagagctt gtgtaatggg gtattgaggg aaaaatgctg tagattgaaa 286800 

gactttttta aaaagtgtgg ttatagggta gaggcttgcc aaacttgtgc tttgggaata 286860 

agaagctgga aatgttgtac aggatacatg gcaggatgga gagagtacag gcaagtcata 286920 

tgtagtattc tatgcaaaaa tcatgatggt aagaaaaaaa gatgttaagg gtagcagaga 286980 

catttcaagc agatgcaaca aatgcttaca gcatggatgg tgaaatgtag ggctaaaatt 287040 

taaagatgat taatgaaagc ggatgacttg tcctttgaag tgaaattact tatttaaccc 287100 

aaacacatat gaatacctaa ttccggaaac atttgttgtc atcattctat ttatagttca 287160 

tgacttgcaa gaataaaata aggcatcttg cacaaatagc tttcttttcc tgacaaatct 287220 

tattgaataa gagattgtca gatataaaga gtttagtcat tacagatgga aatgagagct 287280 

gtactgctaa gactctgact tatttatctc atttattggc agtttcccaa aagggaagac 287340 

agagatatat taaggtttac ttatgttact tccctttgtg caatctagtt caccctcagc 287400 

ctgattcaag ggaggcagca ttatggtcag attaatcata tatttagaaa aaaaatgttc 287460 

tctaggttac ttagcattga aaaagttata tatttatatt aagctcttga actcagatca 287520 

gttaaaccca taaagaatga gcttgaaatg caagaaacac atcctggagt cattctgatg 287580 

ggattgctaa acttttcatc ctgggcatag agcagataaa aatgatgctt ctctgattta 287640 

acaaaagagt aacaggcata agacatctgc tgatgaaagg tgcaagcatt ttgacttaag 287700 

ggggtccctt tataatgttt gaatggaaac tgtgatacac cgtatcttat catctttgaa 287760 

agtgttcagc ctcctccaaa atgaagtgat tattctgttt ctagggaaag ataatgcact 287820 

ggtttaataa aagctgaatg ccaaagacat caatagtata atgatggtaa acttggcatc 287880 

tctgtccttt agttactgag agaaaaagtg tgttgtacat atttaggaca taataaatgc 287940 

caaacacttt gaaaggtaca ttcacacact tttcttattt taacctcata acagacttga 288000 

aagtattatc gttattattt ttacagataa agaaatgttc ctcatatcac atagtaagga 288060 

tcaggcctag aatttgaata caggtctgta cttttctaag ctatcttcta ttaacaaaca 288120 

gcgataaagc atgatgcttg agagtgtggt ccctaacagc cacttacggt gaacactggg 288180 

aaagaattct ctttgtttga ggtaaaaaga gccatggctc agcagaacac tgaggctcag 288240 

aggaaagcct agagttacta ctgtgatctc cctagatctg tgggaagtga gaggacttga 288300 

gaaacattcc cagctgaccc cacatttcca cacatatcag gaaacagtac ctgacagaat 288360 

gtgggttaga attaaatact agcgatgatg gtggagttgg aatttcatta acaaaaccag 288420 

atggaggtta ccctcacacc tctgaannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 288480 

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 288540 

nnnnnncccc ccaccccaca acagtcccca gagtgtgatg ttccccttcc tgtgtccatg 288600 

tgttctcatt gttcaattcc cacctacgag tgagaatatg cggtgtttgg tttcttgttc 288660 

ttgcgatagt ttactcagaa tgatgatttc caatttcatc catgtcccta caaaggacat 288720 

gaactcttca ttttttatgg ctgcatagta ttccatgttg tatatgtgcc acattttctt 288780 

aatgcagtct atcattgttg gacatttggg ttggttccaa gtctttgcta tcgtgaataa 288840 

tgccgcaata aacatatgtg tgcatgtgtc tttatagcag catgatttat agtcctttgg 288900 

gtatataccc agtaatggga tggctgggac aaatggtatt tctagttcta gatccctgag 288960 

gaatcgccac aatgacttcc acaatggttg aactagttta cagtcccacc aacagtgtaa 289020 

aagtgttcct atttctccac atcctctcca gcacccgttg tttcctgact ttttaatgat 289080 

tactattcta actggtgtga gatggtatct cattgtggtt ttgatttgca tttctctgat 289140 

ggccagtgat gatgagcatt ttttcatgtg ttttttggct gcataaatgt cttattttga 289200 

gaagtgtttg ttcatgtcct ttgcccactt tttgatgggg ttctttgttt ttttcttgta 289260 

aatttttttg atttcattgt agatttcaaa accgctcaac tacatggaaa ctgaacaacc 289320 

tgctcctgaa tgactactgg gtacataacg aaatgaaggc agaaataaag atgttctttg 289380 

aaaccaacaa gaacaaagac acaacatacc agaatctctg ggacacattc aaagcagtgt 289440 

gtagagggaa atttatagcc ctaaatgccc acaagagaaa gcaggaaaga tccaaaattg 289500 

acaccctaac atcacaatta aaagaaccag aaaagcaaga gcaaacacat tcaaaagcta 289560 

gcagaaggca agaaataact aaaatcagag cagaactgaa ggaaatagag acacaaaaaa 289620 

cccttcaaaa aattaatgaa tccaggaact ggttttttga aaggatcaac aaaatagata 289680 

gaccactagc aagactaata aagaaaaaaa gagagaagaa tcaaatagac acaataaaaa 289740 

atgataaagg ggatatcacc accgatccca cagaaataca aactaccatc agagaatact 289800 

acaaacacct ctatgcaaat aaactagaaa atctagaaga aatggagaaa ttccttgaca 289860 

aatacactct cccaagacta aaccaggaag aagttgaatc tctgaataga ctaataacag 289920 

catctgaaat tgtggcaata atcaatagct tgccaaccaa aaagagtcca ggaccagatg 289980 

gattcacagc cgaattctac cagaggtaca aggaggaact ggtaccattc cttctgaaac 290040 

tattccaatc aatagaaaaa gaaggaatcc tccctaactc attttatgag gccagcatca 290100 

ttctgatacc aaagctgggc agagacaaaa ccaaaaaaga gaattttaga ccaatatcct 290160 

tgatgaacat tgatgcaaaa atccccaata aaatactggc aaactgaatc cagaagcaca 290220 

tcaaaaagct tatccactac gatcaagtgg gcttcatccc tgagatgcaa ggatggttca 290280 

atatacacaa atcaataaat gtaatccagc atataaacag aaccaaagac aaaaaccaca 290340 

tggttatctc aatagatgca gaaaaggcct ttgacaaaat tcaacaacgc ttcatgttaa 290400 

aaactctcaa taaattaggt attaatggga tgcatctcaa aataataaga gctatctatg 290460 

acaaacccac agccaatatc atactgaatg ggcaaaagct ggaagcattc cctttgaaaa 290520 

ctggcacaag acagggatgc cctctctcac cactcctatt caacatagtg ttggaagttc 290580 

tggccaggac aattagtcag gagaaggaaa taaagggtat tcaattagga aaagaggaag 290640 

tcaaattgtc cctgtttgca gacgacatca ttgtatatct agaaaacccc attgtctcag 290700 

cccaaaatct ccttaagctg ataagcaact tcagcaaagt ctcaggatac aaaatcaatg 290760 

tacaaaaatc acaagcattc ttatacacca acaacataca aacagagagc caaatcatga 290820 

gtgaactccc attcacaatt gcttcaaaga gaataaaata cctaggaatc caacttacaa 290880 

gggatgtgaa ggacctcttc aaggagaact acaaaccact gctcaaagaa ataaaggagg 290940 

atacaaacaa atggaagaac attccatgct catgggtagg aagaatcaat atcgtgaaaa 291000 

tggccatact gcccaaggta atttatagat tcaatgccat ccccatcaag ctaccaatgc 291060 

ctttcttcac agaattggaa aaaactactt taaagttcat atggaaccaa aaaagagccc 291120 

gcatcgccaa gtcaatccta agccaaaaga acaaagctgg aggcatcaca ctacctgact 291180 

tcaaactata ctacaaggct acagtaacca aaacagcatg gtactattac caaaacagag 291240 

atatagatca atggaacaga acagagccct cagaaataat gccgcatatc tacaactatc 291300 

tgatctttga caaacctgag aaaaacaagc aatggggaaa ggattcccta tttaataaat 291360 

ggtgctggga aaactggcta gccatatgta gaaagctgaa actggattca ttccttacac 291420 

cttatacaaa aatcaattca agatggatta aagacttaaa cgttagacct aaaaccataa 291480 

aaaccctaga agaaaaccta ggcattacca ttcaggacat aggcatgggc aaggacttca 291540 

tgtctaaaac accaaaagca atggcaacaa aagacaaaat tgacaaatgg gatctaatta 291600 

aactaaagag cttctgcaca gcaaaagaaa ctaccaacag agtgaacagg caacctacaa 291660 

aatgggagaa aatttttgca acctactcat ctgacaaagg gctaatatcc tcctccttct 291720 

tcttcttctt ctccttcttc ttcttcctct tcttctcttc ttttttttct ttttcttcct 291780 

tttcttctcc tctctctctc tctctctttc ttttgctgct tggtaactcc taagaaattt 291840 

tagctcagaa aacacttatt tgatacattt gtatgtgatc tttacttccc ttctgttctt 291900 

tctttcctct cttccttcct gtaagttttg ccagtttcag aggcagaatc aaatagaaaa 291960 

agactaccct tcatgaagcc agtcttaaaa gagagactgc tgggactctg ttgaagtgga 292020 

agactttttt aaccaagatg acaaggaaag cattgctaaa ggtagaatca aaatcaaagc 292080 

agtgtttaag agggcacatt cccatgaacc tgggaagttg atgtggatgg tcaattctga 292140 

aaagtgaggt gaggatgaaa ataggaggat gaaaagctct gggaatatca agagtaagac 292200 

aatgaatgtt acaggaataa gtcaggacaa gctaaagttc tggaaagaag agagtgctga 292260 

tgctctaatt tttatgtggc atttggtatg cagtgtaggt gattatgcaa agaaatttta 292320 

taggactggg tatttatttt gtattttgtc aaatatcttg tgcatcaaaa agcttcttat 292380 

ggatgaattc tacttataac atattgagcc tttctttgtt gttgttttga ctttgaaaaa 292440 

tatttgacct actcataaag aaaatatatt gacagttatt ttccccctag agggagtata 292500 

tgtgtaggaa ctagcaagag tgaagtcata attttggacc taatcttagg aataccatga 292560 

tgtgtcattt ctctgacttc taaaattgaa gtcaaagaga gatgcaggat cattttctat 292620 

tctttggcaa aaggtattat agaaatgcag agtatcggcc tatcatttac acagccttga 292680 

actgtgctgt cctcagaata caaaacagaa aattgcagtt ggaggctatt gcaactgact 292740 

tcctctgatt catgaataat ttccattcaa ctcaaatagc agaaataacc ctcaataaga 292800 

aagaggcaca tgatagctcc acctatcaat ccatgcaggt gaacataaaa ctaccaactt 292860 

ttacatggac agatgtgatt tgttatctcc atcctagtgg aaaaataaaa tcaaatttat 292920 

actttaccgt gcttaagaag acaccgactc acggttaatc gctgtgattc attcctaagc 292980 

cattgctctt ccttcaaagc tgaagcatga cccagtcagg ttcactacta attcatgtag 293040 

cagccacatt tacaactgaa atgcaagggt gggggttcaa ggtggggtga aggtggaggg 293100 

gaggggaggt gagggggaag tagctctagg aaatatcaga tgattatcta cttatctagt 293160 

tatcagatga ttatctgtta tctagttaat agaaaagtga taggtaacca aagagattaa 293220 

atgtaagaca catatttgta attataggtt acaatttgta attgctattt gttatttgta 293280 

attgtaggtc aatccagaaa tggagacaat tcctggctgc atacatccac ataatgtaat 293340 

ttactgcata gattattaac tgcatagtac ctagttcact gcaataaact acaataattt 293400 

acaataaaca tttttttcca aaagcatcaa gttatatttt tgctgttgtt tagatgtgtc 293460 

tggtatataa atggaacaac attgctctaa gtagaattgt ttctttaaaa gtaagatccg 293520 

ggaaacgttc ataactactc tgcatctctg ttacaatagt aagggtgcag aacatgtcag 293580 

ctaaagggtg tctagtcccc agcatgatgc ctggcagtaa atcaaggatg agccttcact 293640 

gcttcaagtc ctttcatcta gaatgcttca gtgagttttt atggggaaat catttccccc 293700 

tctttcttaa gatcatttat catttagttg tataaactga tatttacatc tgtcacaaat 293760 

gctcaaccct atcccagagc atattaaggg aaacttgtgg aatatttatg tgttatgtgt 293820 

atacaaaaag aggttgtcta caaaacctct ataaaagaca agttgccatt tcccatacct 293880 

tgggggaata gtagaagcac ttttctcttc tcccctatgc tgaatttact gccattttct 293940 

tgccttcttt ataggaaact ctaccttttg tgtatttaaa acactgctag gtgtttgtgg 294000 

aaaacagaag aagaaacttg ctactttcta atttttgttg ttgagaagac acaataatat 294060 

ggtattttat agttagggtt gtcaaaagca aatctgtgct tcgccacata acagcaggac 294120 

ctttggaaaa ttatttgact gttctaaatg ccagttccct ctctgtaaca tggaaacata 294180 

atagcattga ggtctcaaag tttctgtaca tgaaataatg tacatgaagc acattgtaca 294240 

ttgcctcttt aattctcaaa ccactccatg aagtgaaact attattattt ctcattcaac 294300 

agatttgttc attaaatttc ccaaggtcac tctgttaact agtagtggac atggtattca 294360 

aacccagctc tgcctgactc tagggcctga actccttatc actcatgaga ctcctcccta 294420 

ggtacttcac tagtttctaa caaggaagga tttaagtcac cgtcagagct ctgctatata 294480 

atcaattctt gtatttgtga tatttgtaat ttggtctagc cttattgtat agaaacctgt 294540 

tgtattagtc cattcccaca ctgctatgaa gaagtaccca agactgggta atttataaag 294600 

aaaagtggtc taattgactc acagttcctt atggctgggg aggcctcagg aaacttacaa 294660 

tcatagcaga aggcacctct tcacagggct gcagaagaga gaatgagagc aagtagggaa 294720 

aatgtcaggt gcttataaaa tcatcagatc tcatgagact cactatcacg agaacagcat 294780 

ggggggaacc acccccagga tccaattgcc tccacctgtt tctgcccttg acctgtgggg 294840 

tttttaagga ttataattca agatgagatt ttgggtgggg cacagccaaa ccatatcacc 294900 

tgtctccagt tttcatacca tactacagat acagccattt cacatccaat cgtgggttat 294960 

tgttttaaaa tcacacatct aaaaatctcc tcaagcattg ctctaatttg atatctaaca 295020 

ggtaattccc aaaggctagc tgcagtgaag gttctggggc tcagggtagg cagagcaact 295080 

cagcagctgg tataaaatgg gctcttctcc aggtgtcctg caggttacac ttatattcac 295140 

aaatgttaat ccagctgcta cctgtttgaa attgctaata gagttataac agattacctt 295200 

tcttcaagcc aataccagaa aattcaaacc agagacaaaa ttagtcctgc aggtactggc 295260 

agcttaataa tagcttatcc ctgaggatct caatctttgt ggtctcagaa aaagtgcttg 295320 

taaaaagcat tgaagatcca aaagtagtta tgtgtgttaa ttatgtatta ctgggctcca 295380 

tattaaaaat taaaactgat acttttattt gaaataacaa taataaaccc attacatgtt 295440 

agtataaatt aatgttaaca taaacacctt taaataaaaa atatattttt caaaacaaaa 295500 

aaaattagtg aggagtatgg cgttgttaaa catttttgca aatctccttt atggcttaat 295560 

aaaagataac tggattttta catctgcttc tgcattcaat ctgtcacagt attacacttc 295620 

ctgtagattc tggaaaatgt cattcttcac tcatgaggga ataagaagga aagaaaatat 295680 

aacattttag aatgatgatt aagatagttt tgaacttaca gaatccctgg aaagatcttg 295740 

gggacataca agagtctcta cccgacattt tgagaaccac tagctagaag tatacttgat 295800 

atagctagaa ataaacttga tgccataagg aatgtcctac tgatgcagtt ggtttgattg 295860 

atagttcaat aatattcatg actaaaatca ttcaagcttt aaaaagtaga ctatttagta 295920 

acacaaggtt tgaatttgtg agttccaaaa cttttacaca agtagtggga aggtctggga 295980 

cctttgtcat tatagctttt gcagatgtca gaaataatag tatttctttc ctatgatctt 296040 

tgttcactta gagtgtgatc tgactggtgt caaaagtcac ttaaaagact ggttgtgaga 296100 

ttcaaatata tattccttcc aagagtattt actggacagt gaggtaccca tcttcaaagg 296160 

atccagcagg catctggtgt gtaaacaagt ctgtggtggc ccagttggct ttcttttcca 296220 

caggttctga gggagtccac atctccccct tttttccact gtgtccttta gcggaccact 296280 

tcagcacaca tagcctggtt ctcttgcatt gtaacaggcc cacagaatct ctgggcactt 296340 

atgctttcct gcttctgagc atattcctta tagtttccat ggttacattg gtgaagctcc 296400 

aagtagtcca gatggctgca gaacacagtt ctttgattac ctctcctcag agtacccacc 296460 

tgctttcttc cgtcccattt gattttcttt catccttggc ccaaggagat ctttaacagc 296520 

ctgcagttcc tagtgacctt gttaatttgt gaagctcatt ccaaatagtc tccattagta 296580 

atattcagct aactctgcag ttagttaggc atataataaa ccttgaaaat aagtctgata 296640 

ccaatgttat caatatttat aaattttctt aaatcttata aaatcatcat tattgctgct 296700 

atgcacaagt tcttaaaatt taacatattc atatcatgca tcttgcaatt tgtaggactt 296760 

tcttagaact actgtgatat aaatcataac ataaaatatc agttatgatg tatcaataag 296820 

tgataagcta acatatttgt aactattttc agtttaaaaa gtcctttcat agacattatt 296880 

tcatttaatc cccaacaaat gctctttcag atagttacct cttatgccta ttttacaaat 296940 

gagaaaaaga aatgaggcaa tgggaggtta attaacttgt ttgagtaatc aacaggctgt 297000 

tttccaatta tgggtcttca gattaacaac ttagcccctt tctgttatac tggtgttttg 297060 

tgtatttaag gtatttccat attatttgcc atatccatgt gctcgaattt gctgtatcaa 297120 

ataaagctat ttaattctag ttggaaactg ttgcctacta aaaaaacaaa aacaaaaact 297180 

tagggggaaa atagcatgag gttgagaagt tgttaaagtc ataccaatac caaactgtgg 297240 

cttcctcttt aagaactgaa aggaaattga ataaggaata actttaacaa tacactacgt 297300 

ataatccttt taatatctac ccatgcttgc tcattgaatt ttgagcactg tcttcaatca 297360 

ttctgaatcc cttgcctcaa tgagttccaa gtctcccata aagcaggtga tcaaccaaaa 297420 

tcttttaaaa ctgtttgaaa gtggagaccc ccccaaaagg aaatcaatat gtgactttca 297480 

gcataaattg tggcatggca tatttgaaaa agtaacggaa gtaaaacaca tttagttagc 297540 

gaagagcatc aagtttatca tagaagtgat tgttgagaat gtcacccaaa ctcacccaaa 297600 

aattcactgc aattgtctag gaggaaggaa gtggagacaa catatagctg attcaggtct 297660 

catttcaaag agcttcttta taggagagaa acatgtatat caagttagga ttccagttag 297720 

gaacaaagat aggatgagcc catgtttccc aatctcttct gtgagagaac actgtaatac 297780 

tggaataaac ataaagaggc tgcggtagct gtaagaactt ccttagaggc taagagttcc 297840 

tgagtggctg ccagagtctg gggatcaata tctctggaaa cttgcagatc acttgtagct 297900 

cactaggcta cagcaccaca ttggtgggaa gctctgctgt aggaaactgc tgagaggacc 297960 

atggaataag aagaaaaaaa catagcccct gacaacaaag aattaattct ttcttccaga 298020 

aaaaaatgta caaagcattg atagtggcag tggcctgtct ggagcagcca ctgtgaggac 298080 

accggctgta gcaggggagt catagccagg gctgcatgct ccatggagct ggcaggggca 298140 

gggcacaggt gatcccagtg ggagtcccac accctacaga gttggcagag tggaagccca 298200 

cactcctggg tgaagctgca gtcactcagc tgtggctctg gacctgggca tccctgtgct 298260 

ctcagggaac ccaggaagct cccagggacc caggaagctc cctgcccctg caggctcaga 298320 

agtgcttctc ccactccctg gcctctccct gctgccagca cccactatgg atgtgtctca 298380 

acagccaagc ccaggcactg ttgtgacccg gctgggtgtg tgcacactca ggatggtgct 298440 

gacatgccag ccccctgctt cctcgacccc cccaaaaaat aacctctaag gctgaaactt 298500 

tgggtgccaa tgagcacagg agggaggttg ggggactgag ggtggctcaa ggcaggcctg 298560 

cagttgcccc ttgatgcaga cagcctgggc accatggatg gcatgttgat ggtggcaaaa 298620 

ggcagaaagg ttcctaggca gcaaggggtg ggtccccact gaaaccccac cttcaagcca 298680 

gggatggcct aaagtctggg ggctgggctt ccagttccag gtaaagtacg agaccctgag 298740 

tgagaacttc cttgatgcct ttcggccaat cagatggtgc tttttccagg cctgcccatg 298800 

gccgctcatg gatcaatcag catgcgcttc caccaaagaa ctagtcagca tgcacatcct 298860 

tcattctgag cccataaaaa ccccacacac agccagactc acacacttat tgggactacc 298920 

tgcctgtgga taggagcttc ccactttagg tctcctctgc actcgttggg actacgtgcc 298980 

tgtggatagg agtaaccact tcaggtttcc tctacactcg ttgggactat gtgcctgtgg 299040 

ataggagcta accactttag gtctcctctc cgctgagagc tgttctgtca ctcaataaag 299100 

ctgctcttca acttgctgac cctccagttg tccatgtaat ttcattcttc ctggatgctg 299160 

gacaagaact caagacctgc tgaacagagg gagttaaagg agctgtaaca cattcctggc 299220 

tggcttgctg agctgcaggg ataacatgct ctcggactgt ggtagtgaag aggggtgacc 299280 

cttctggggg ctcagacctc aggatttccc cagccagagc tgctgtaaca ctatagtcat 299340 

cctgccctcc accagagcca ggcagccatc ccatgcaacg ggaagcagca gcagggctag 299400 

gagccatggg ctggagaggg gcagtgggac tgaaagagtg gtaacacaaa caggctgaaa 299460 

catacccccc cttccatttg ccgcgctgag ggtgacgaga aggagagaag agctgtggcc 299520 

cttctgggag tccagacttc aggctccctg agccagggct gtgacatgct gtaacaccct 299580 

tttgagggct ctgcggttcc tcgtgtctcc aagcttttga tcgctaccat gttcccctca 299640 

ccagtcagtg gtaccctcag tggaaaccac ttacaatacg tctggcccag ctgtaacctc 299700 

atacaaagct ggtgcctgtg ccagcgcctg gagctgcctg ccctgctgca gcagccagca 299760 

tgcctggctg tccacagtgg ccagaccccg cactcacaca cactttgctg caccatacct 299820 

ggcttgccct tgagaggtgt agaaatgcag catctcaggt tgctgcctgt ggtgtgagcc 299880 

aagcacagac tcccaggtca agcatgtgga acaagcccag cgggcacaag caaatctcaa 299940 

gcagagttgc tgctggccac agaggtttcc agctggagaa gtgacaccca aaggaccctg 300000 

tgactgcatt ttgtatgagg aaggcactgt aatagatact atggacataa ggcagatttg 300060 

tattaaacag aattttcagt tttaccttgg agaaggaaaa cattgaccta caacttgtga 300120 

cacatagtga cagacatttt aaatttctca gagcttacaa gtattcaaga aatgactact 300180 

atatatttct ctgccaaatt aaatttcttt tccacactca atttttatat actttacagc 300240 

cattaatttc atggtatgca ttttacttct tccaattgcc tcatcaaata atatataaac 300300 

actttaatct aaatttattt ctctctttcc aggaaaacag tttattgggt actaataata 300360 

taaggggtat tccacttgtg ctttatataa actattttaa acttacatca accccacaaa 300420 

actggaataa tcgcccaatt ttacagatga gaacattttg gccaaagaaa aaaagtaaat 300480 

aatagacaat aacccagcat taaaatggag gcattcctga cttaaaagcc aatccctttt 300540 

cactgccata tatttcagtt ttggaatcta tctccattaa tctttgtatt gagttaataa 300600 

aacaaatata gaaaattatc cactgttaga ctaatgttct tcctctattt acttcacaga 300660 

ctgacagatt gataatcaca tacatatacc tatacatatg tgtattagtg cctttttatg 300720 

ctgctaataa agacatacct gagactgggc aatttacaaa agaaagaggt ttaatggact 300780 

tagagttcca catggctgga gaggcttcac aatcctggtg gaaggcaaag aggagcaagt 300840 

cacattttat atggatggca gcaagcaaag agagagcttg ttcagggaaa cttccatttt 300900 

taaaaccatc agatgtcatg agacccattc actatcacaa gaacagcacc agaaagaccc 300960 

acccccataa ttcaatcacc tcccactggc ttccttccac aacatgtagg aattgtggga 301020 

gttacaattc aaaatgagat ttgggtggag acacagccaa accatatcat tctaccctgg 301080 

cccctcccaa atttcatgtt ctcacatttc aaaaccaatc atgccttccc aacagtcccc 301140 

aaaagtctta actcatttca aaagtccata gtccaaagtc tcatctgaga caaggcatgt 301200 

cccttgcacc tatgagcctg taaaatcaaa agcaagttag ttactttcta gacacaatgg 301260 

gggtatagac attgggtaaa taacagcagt tccaaatgtg agaaattggc caaaacaaag 301320 

gggctacagg ccccaagcaa gtctgaaatc cagcagggca gtcaaatttt aaagctccaa 301380 

aattatctcc tttgactcca tgtcctggat ccaggtcaca tttatggaag taggttccca 301440 

tggtcttggg tagcttggcc cctgtggctt tgcagggtac agcctccctc ctggctgcct 301500 

tcatgggctg gcattgagtg tctgcagctt ttccaggcat atggtgcaag ctgtcagtgg 301560 

atctgccatt ctggggtctg gaggaaggtg gccttcttct cacagctcca ctaggcagtg 301620 

ccccagtagg gactctgtat gggggctcca accccacatt tcccttccac actgccttag 301680 

cagaggtact ccatgagcac cctgcccctg cagcaaactt ctgcctggac atctaggtgt 301740 

ttccatatat cctctgaaat ctaggcagag gttcccaaat ctcaattctt gacttttgtg 301800 

catctgcagg gtcaacacca catagaagct cccaaggctt ggggcttgca ccctctgaag 301860 

ctatggctca agttgtacct tggccccttt tagtcacagc tggagtggct gggatgcagg 301920 

gcaccaaatc actagactgc acacagcaga ggggacctgg gccaggccca tgaaaccatt 301980 

ttttcctcat agccagtgat gggaagggct gccatgaaga cctttggcat gccctggaga 302040 

cattttccag gccagtgatg ggaagggctg ccatgaagac ctttggcatg ccctggagac 302100 

attttcccca ttgtcttggg gattaatatt cagctcctca ttacttacac aaatttctgc 302160 

agcctgctag aatttctcct cagaaatgag attgtctttt ctatcgtgtt gtaaggctgc 302220 

aaattttcca aatttttatg ttgtttccct tttaaaactg aatactttta acagcaccca 302280 

agtcacctct tgactgcttt gctgtttaga aatttcttct gacagatacc ctaaatcatc 302340 

tttctcaagc tcaaagttcc acagatctct agagcagggg caaaatgcaa ccaatctctt 302400 

tgctacaaca taacaagagc cacctttgct ccagttccca acaagttcct catctccatc 302460 

tgagaccacc tcagcctgga ccttattgtc tatatcatta tcagtatttt ggtcaaagcc 302520 

attcaacaag tctctaggga gttccaaact ttctcacatt tgcctgtctt cttctgagcc 302580 

ctccaaactg ttccagcctc tgcctgttac ccacttccaa agtcgcttcc acattttcag 302640 

gtatctacag cagcacccac tttattggta ccaatttact gtattagtct gttttcatgc 302700 

tgctgataaa gacataccca agactgggca atttacaaaa gaaagaggtt tagtgaactt 302760 

acacttccac atggctgggg agatctcaca atcatggtgg aaggcaagga gaagcaagtc 302820 

acatcttaca tggatggcag caggcaaaga gagagctttt gtagggaaac tcccattttt 302880 

aaaactatca gatctcgtaa gactcattca ctatcatgag aacagcacag gaaagacctg 302940 

cccccatatt ttaatcacct tccaccagtt tcttcccatg acatttggga attgtgggag 303000 

ttacaattca agatgagatt tgagtgggga cagaaccaaa ccatatcaac atgttaagaa 303060 

tataactttt aataatatac tttgaaaata taaaatcatc ttttcatata aaaattaatt 303120 

ttggggcaat aggagtagat ctgtaaaaac tcttcaatta ttaagaaatg tatatttata 303180 

ggatcccaat aaaatccttg tctgatgtac tgaaagtcac atattgtttc cttttggggg 303240 

atctccactt tcaaatagct ttaatagatt ttggttgtgc acttgcttta taggagactc 303300 

tgaactcagg attcagaatg attgagaata gtgcctaaaa ttcattgagc aagttcttac 303360 

tcagtagatc tgaggtaagg cctaaaatgc tgcatttata gcaagctcac aggtgaggct 303420 

aaaactgctg gtcctggcat cacactctga ggagtagggg tccaggatat acgcattaaa 303480 

ctatggtcca aagaccagtg ctagtcagga aactgttggt tccttatctg caatgagttt 303540 

atggtagaga ctgagggtga gcatttagac aattttagca ctttgtggag taattttatg 303600 

tttgttaaac ttaataaaat aaaaaaattg gggcttgctt ctatttcata tgactttttt 303660 

aaaaatttca tctttccagt aattattttt atcatatttt ataaaaatat tggtctgtga 303720 

taggtggaag atgatatata taactagtta tatataatta attatttata atatgagtat 303780 

ttattacata tataatatat tactatatat tatatattag ttatatataa tcaattaatt 303840 

ttatatagct agttatatat ataacttgct atgtatataa ttatatacag ctggttttag 303900 

atataattat atataatatg taacataaat atataataca tttaatatag ctagctatat 303960 

ataattaaca tattatatag aacacatata actagtttat atataacata cataactact 304020 

tttataaatt aatatatatt atatataaca tatataaaac tcattttata aaatatatat 304080 

aaaactagta acctttgtgg tgaaggacta ctatatgtgt atagcagtcc tatatgtata 304140 

tatatgtacc atatgtatat agtagtcctt caaaaatgtg ttaatacata tataccatag 304200 

aatactatgc agtcataaaa aagaatgaaa tcatttgtgt tgaaggatta gtcatatata 304260 

tataaaacta gtccttcacc acaaatgatg taagaagcat gagtctagga caatgcccct 304320 

ggctcatgaa acttacaata caatgggaga actatgacaa gcatcaaagg taccaatgca 304380 

gaaagaaaca tgtagccaca atataatctt aaggtttgct tacaaaggtg tgtttctcca 304440 

tcaaacaaac actccattca ccgaaagaaa acagcttatg atgcatcctt aataaagaat 304500 

gcttacattt gcctttttag cttgacatgt attcttttct gataccaatg cagaaagaaa 304560 

catgttgtca caagacaaca caaaggagaa tgtgatgaag accatttaag aaatgaagag 304620 

ttctaagcgt tctgaggact gaacagaagt aaaaggatcc agcattcgtg gagtatctgt 304680 

ttatgtacac acataatgtt aagtccttaa catttaagcc acataaaatc ccattttgaa 304740 

aatgaggaaa ttgaagacca gggagtttaa gtaactaact gaagattcag aaggagcagg 304800 

gctggaattg agatctagct ataatgtgta tgtatgaact gtagatcctc atatttttga 304860 

acaccctctc tacattctgc taggatccca cactgtgagt ctcattttcc taaggtgaac 304920 

tccagaaact agatttccag acttcattac agtgagggtg caggtacatg atgtaggttt 304980 

tgtaatatga agactggaca gaccagagct tggaaacata ggcaccagac tatggatcag 305040 

acagaagaca ctgttggttt ctgatgtggg ttgaattgtg tccctgtccc caccccttag 305100 

gttcatatat tgaaatctta accctagtaa ctcagaatgt gacttcattt ggaaataggt 305160 

tcattgcaga tgtgatttgg attgagcagg cccctaatcc aatgtgactg gtgtccttat 305220 

aagaaggaga tttttttttc attttttttt gtttatttct atttttataa tctcaacttt 305280 

tattttagat tcagagggta catgtgcagg tttgttacat gggtatattg cattatgcta 305340 

aagtttggga catgaataat cctgtcaccc agatagtgag catggtactc agcagttagt 305400 

ttttttaacc tctgtccccc cattagtctc cagtgtctat tattgccttg tttatatccg 305460 

taagttccca atgttggcca ggcacggtgg ctcacacctg taatcccagc actttgggaa 305520 

gccgaggcga gtggatcatg aggtcaggag ttcgagacca gcctggccaa catagtgaaa 305580 

ccccgtctct actaaaaata caaaaattag ctgggcatgg tggcacacac ctgtagtccc 305640 

aggtactggg gaggcagagg caggagaatt gcttgaaccc aggaggcgga ggttgtggtg 305700 

agctgagatc atgccactgc actccagcct ggtgacagag caagtctcca tcaaaaaaga 305760 

ataataataa caaaaaataa ataaatacca aagttcccaa tgtttaactc ccacttgtaa 305820 

gtgggaatgt gcagtgttgg aatttctgtt cctctgttat tttgcttagg ataatggcct 305880 

ccagctgcat caattttgct gcaaatgaca tactttcaat cttttttatg actgcatatg 305940 

tattccatgg tgtatatgtt cattttcttt ttccagtcta ccactgatgg gcacctaagt 306000 

tgattccatg tctttgctat tgtgaatagt actgtgataa acatttgagt atgtgtcgtg 306060 

ttggtaggat gatttatttt ctttggatat atacccagta atgggattgt tgggttgaat 306120 

ggtggctctg tttcaagttg ttgaggaaat ctccaaactg ctttccacag tagctgaact 306180 

aatttttact cccaccaaca tggataagtg ttcccttttc tctgcagctt ctctagtatc 306240 

tgttattttt tgacttttta attatagcta taatgaagta aaacacccct cagcaaatgc 306300 

aaaagaatgg aaatcacaat gaacagtctc tcagaccaca gtgcaatcaa attagaactc 306360 

aggattaaga aattcactca aaaccactca actacatgga aactgaacaa cctgctcctg 306420 

aatgactact gggtaaacaa tgaaattaag gcagaaataa ataagatctt tgaaaccaat 306480 

gagaacaatg acacaatgta ccaaaatctc tagcatacag ctaaagcagt gttaagaggg 306540 

aaatttatag cactaaatgc ccacatcaga aaactggaaa gatctaaaat cgacacgcta 306600 

acatgacaat taaatgaact agagaagcaa gagcaaacaa attcaaaagc aagcagaaga 306660 

caagaaataa ctaaaatcag aacagaattg aggaagatag agacacgaaa aacccttcaa 306720 

aaaaatcaat gaatccagga gctggttttt tgaaaagatt aacaaaatag atagaccact 306780 

agccagacta ataaagaaga aaagagagaa gaatcaaata gacacaataa aaaatgataa 306840 

aggggatatc accactgatc ccacagaaat gcaaactacc atcagagaat actataaaca 306900 

cttctatgca aatgaactag aaaatataga agaaatggat aaagtctggg acacatacat 306960 

ccttccaaga ctaaaccagg aagaagtcaa atccctgaat agaccaataa caagttctga 307020 

aattaaggca gtaattaata gcctatcaac caaaaaaaag cccaggacca gacagcttca 307080 

cagccaaatt ttaccagagg tacaaagagg agatggtact attccttctg aaactattcc 307140 

aaacaataga aaaagaggga ctcctcccta actcacttta tgaagccagc ctcatcctga 307200 

taccaaaacc tggcagagac acagaaacaa agaaaatttc agggcaaaat ctctaatgag 307260 

tatcgatgaa aaaatcttca gtaaaatact agcaaactga atccaacagc acatcaaaaa 307320 

acttattcac cacaatcaag ttgacttcat ccctgggatg caaggctagt tcaacttaca 307380 

caaatcaata aatgtaatcc atcacataaa cagaaccaat gacaaaaacc acatgattat 307440 

ctcaatagat gcagaaaagg ccttcgataa aattcaacac ctctttatgc taaaaacact 307500 

caataaacta ggtattgatg gaacatatct caaaataaga gctatttatg agaaacccac 307560 

agccaatatc atactgaatg ggcaaaagct ggaaacattc gttttgataa ccagcacaag 307620 

acaaggatgc cctctctcac cattcttgtt caacatagca ttggaagttc tggccggggc 307680 

aatcaggcaa gagaaagaaa tgaaggtatt caaataggaa gagaggaagt caaattgtct 307740 

ctgtttgcag atgacatgat tgtatatttc taaaacccca ttgtctcatc ccaaaatctc 307800 

cctaagctga taagcaactt cagcagtctc aggatacaaa atcaatgtgc aaaaatcaca 307860 

agcattccta tacaccaata atagacagag agctaaatca tgagtgaact cccattcaca 307920 

attgctacaa agagaataaa acacctagaa atacaactta caagggacgt gaaagccctc 307980 

ttcaaggaga attacaaacc actgctcaag gaaataagag agaatacaaa caaatgaaaa 308040 

actttccatg ttcatggata ggaagaatca atatcatgaa aatggccata ctgaccaaag 308100 

caatttatag attcaatgct attcccatca agccaccatt gactttcttc acagagctag 308160 

aaaaatctac tataaatttc tttttttctt tttaattata ctttaagttt tagggtacat 308220 

atgcacaacg tgcaggtttg ttacatatgt gtacatgtgc catgttggtg tgctgcaccc 308280 

attaactcat catttaacat taggtatatc tcctaatgct atccctcccc cctcccccac 308340 

cccccaacag gccctggtgt gtgatgttcc ccttcctgtg tccatgtgtt ctcattgttc 308400 

aattcccacc tatgagtgag aacatgcggt gtttggtttt tcatatggaa ccaaaaaaga 308460 

gcccatataa caaacacagt cctaggcaaa aagaacaaaa ctggaggcat catgctacct 308520 

gacttcaaac tatactacaa ggctagagta accaaaacag catggtagtg ataccaaaac 308580 

agatatatag accaatggaa cagaacagag gcctcagaaa taataccaca catctacaac 308640 

cacctgatct tcagcaaacc tgacaaagac aagcagtggg gaaaggacaa cctatttaat 308700 

aaatggtgct tggaaaactg gctagccata tgcagaaaac tgaaactgga ccccatcctt 308760 

ataccttata caaaaattga ctcaagatgg attaaagatt taaacataaa acttgaaaca 308820 

taaaaaccct agaagaaaac taggcaatac cattcaggac ctagccatgg gcaaaaactt 308880 

catgactaaa acaccaaaag caatgttaac aaaagccaga attgacaaat gggatctaat 308940 

taaactaaag agcttctgca cagcaaaaga aactatcatc agaatgaaca gggaacctac 309000 

agaatgggag aaaatttttg caatctatcc atctgacaaa gggctaatat ccagaatcta 309060 

caaggaagtt aaatttacaa gaaaaagaca accctatcaa aaagtgggca aaggatatga 309120 

acagacagtt ctcaaaagaa gacatttatg cagccaacaa acatatgaaa aaaagctcat 309180 

cattgctggt cattagagaa atacaaatca aaaccacaat gaggtatcat ctcacgtcag 309240 

ttagaatggt gatcattaaa aagtcaggaa acaatagata gggaggatgt ggggaaatag 309300 

gaatgctttt acactgttgg tgggagtgta aattagttca accattgagt aagacagtgg 309360 

tgattcctca aggatctagc atcagaaaca gcgtttgacc cagcaatccc actactgggt 309420 

atatacccaa aggattatac atcattctgc tataaagaca catgcacgtg tatgtttatt 309480 

gcggcactgt tcacaatagc aaagacttgg aagcaaccca aatgtccatc aatgataaac 309540 

tgtgtaaaga caatgtggca catatatacc atggaatatt atgcctccat aaaaaagaat 309600 

gagttcatgt cctttacagg gacatgaatg aagctggaaa ccatcagtct cagcaaacta 309660 

atacaagaac agaaaactgg gccgggggca gtggctcacg cctgtaatcc cagcactttg 309720 

ggaggctgag gcgggcggat cacgaggtca ggagatcgag accatcctgg ctaacatggt 309780 

gaaaccctgt ctcttctaaa aatacaaaaa attagccggg cgcggtggca ggcacctgta 309840 

gtcccagcta cttgggaggc tgaggtagga gaatggcgtg aacctgggag gagaagcttg 309900 

cagtgagctg agatagagat tgcaccactg cagtctggcg tgggtgaaac agtgagactc 309960 

catctcaaga aaaaaaaaaa taaagaacag aaaaccaaac acggcatgtt ctcactcaca 310020 

agtgggagtt gaacaataat aacacatgga cacagggagg ggaacatcac acactgggtc 310080 

ttgttggggg tagggggcaa ggggagggag agcactagga caaataccta atgcgtgttg 310140 

ggcttaaaac ctagatgagg gttgatgggt gcagcaaact actatggcac atgtatacct 310200 

ctgtaacaaa cttgcacatt ctgcacatgt atcccagaac ttaaagtata ataaaaaaga 310260 

taataataat agctataatg actggtatga gatggtatct cattgtggtt ttgatttgca 310320 

tttatctgac cattagtgat gctgagcacg ttttcatatg tttgatggcc acttgtatgt 310380 

ccttgttttg agaagtgtct gttcatcctt tttgcccact ttttaatggg gttgtttttt 310440 

gcttgttgat ttaagttcct tatagattct ggatattaga cctttgtcag atgcatagtt 310500 

tgtgaatatt ttctcccatt ctataggttg tctgtttact ctgttgttag tttctgttgc 310560 

tgtgcagaag ctctttggtt tacttagatc ccacttgtca atttttgttt ttgttgaaat 310620 

tgttttaagg ccaatgtcca caagggtgtt tcctaggttt tcttctagaa ttttctttct 310680 

ttctttttat ttttttttta tttttgagat ggagtgttac tctgtcaccc aggctggagg 310740 

gcagtggcac aatctcgatt cactgcaacc tccacctccc aggttcaagt gattctcctg 310800 

cctcatcctc ccaagtagtg ggattacagg cataagacac catgcccagc taattttttt 310860 

atttctagta gagatggggt ttcaccatgt tggccaggtg ggtgccgaac tcctgacctc 310920 

aggtgatcca cccacctcag cctcccaaag tgctgggatt acagatgtaa gccaccatgc 310980 

ctagcttctt ctaggattct tacagtttga ggtcttatat ttaaatattt aatctgtctt 311040 

gagttaattt ttatatatgg taagagaggt ccagtttcat tcttttgcat atgtctagac 311100 

agcaatccca gcaccaatta ttgaataggg agtcctttcc ccattgcata ttttcatcaa 311160 

ctttgtcaaa gatcagatgg ctgtaggtgt gcagctttac ttccaggctc tctattctgt 311220 

tccattggtt tatttgtctg tttttatact agtaccatgc tgtttggact acttagcctt 311280 

ataatatagt ttgtagtcaa ggaatgtaat gtgatgctta cagctttgtt tttgttgttg 311340 

ttgttgttgt ttgtttgttt gtttttgctt agattgcttt ggttatgcag tctctttttc 311400 

agttctatat gaattttaga atagtgggaa ttttttttac tctgtaaaca ataacattgg 311460 

tagcttaata ggaatagtgt tgaatctgta gattgctttg gtaagtatgg ccattttaat 311520 

aatattaatt cttctaatcc acgagcatgg aatgtttttt atttgtttgt gtcatcttga 311580 

tttcttttag ctgtgttttg tagttctcct tgtagaggtc tttctcctcc ttggtttaat 311640 

gtattcctag gtatattatt ttggggaggg ctattgtaaa tggaactgca ttcttgattt 311700 

ggctctcagc ttgaatgtta ttggcataca aaaatgctat tgatttttgt atgccaataa 311760 

cattgatttt gtatcctgaa actttactga agttatttat gagttccagg aggctcttgg 311820 

tggagtaata gagtaatatt gttagtaaag agagatagtt cgacaatttc tttttctatt 311880 

tggatgcctt ttatttattt ctcttgcctg attgctctgg caaagaaata aggggatatt 311940 

ttgggtatag acacacatac aaggaaagta ccatgtgaag atgaaggcag atgtcaaggt 312000 

aatacaagag aagccaagga atgccgaaga ttgccagcaa accactagaa gctagaagag 312060 

agtcatggga tggattctcc ctcatagacc gtagaaggaa tggaccgtgc tgacaccttg 312120 

atctctgatt tctagacccc agaactctga gacaataaat tgctgttatt taagcaaatg 312180 

ttaacaattt ctagaagaaa tattgcagct atcaaattga aaaatctccc tacatgtggg 312240 

gcagaatttt aaaaaaaatc acccagtact atcaaagtag catggcaaaa catcaaaggt 312300 

aatgggaaaa atattaaaaa ttgatataaa ttttatgttt tgtgtattct gtcataattt 312360 

ttaaaaattg caaaaaatga tcagatagga aagatataag tgaacatgtg agtttaatct 312420 

tggggtgatt ttatagggtc tgagaaaggt gtggaaggaa gcaagagcaa aggggatctg 312480 

cttttcaaat attggcaata cctccatctc gacttcatct tcgttggatt ctggcagcac 312540 

agtagctggt gaagctcgtg tttggccaca gaatgcaagg gtaggactag aaaattaagg 312600 

gattgtcagg gatgtgtgtg tacacatgta gggaaaactc ctctttccat aattagtagt 312660 

tcctggatat gttggaaaga ataaagctca atatatcagt atatatccat tcagtctgat 312720 

atatatatat taaatacctc atctaagcca ggcactactt aggtttatac acacaaggat 312780 

aaataaaaca gagtttcttc cttcattcgt gggtaatttc actctgttgt actatttatt 312840 

acagttacag aaacaagata caatttttga aggtaatcta ttcagggtaa atattccatt 312900 

caaatggctt taaggatatt tgctggaacc tttcttgaat gtagaccttc ttttctagaa 312960 

ctttgctaca tgcctttgca ctccatcttg atgagatggt taagaaaaaa aaacataaat 313020 

aagcagatcc acgtgcttat catttaggta tcaatattat tgcctcaatt ttttctaaat 313080 

actttaagga ggcagataaa gatgatttat acactgaata tacttgagca tcggtgtaaa 313140 

aattcagtat taagacatta ctaaatttac tttcaacgtc caaactaaat gtgttttcaa 313200 

attaagtcga agcaactgca gagaagtcaa atatttgctc tcattaataa tacactggta 313260 

ctaaaaagaa gaataatgac actcttataa aggttttctt taacatctct aaaagattac 313320 

taatcatatt ttattcatcc ttaccacagt ttgtttttgt ggactacttt attagattta 313380 

tttcatggaa gtttttctca agtttcagca attggctaaa caatcaatac tttagctatc 313440 

aaagaaaact ttcctgagga ggaagaaatt tcttcttgaa tgaccttttt ttcaggagag 313500 

cacccatcac agatgaagaa ccaggtcact ctggaagtca agtctcacta aagcttgaag 313560 

cttctttttc tttctttctt tctttctttc tttctttctt tctttctttc tttctttctt 313620 

tctttttttt tagacagtct cactctgttg cctgggctgg aatgcagtgg tgcaatcttg 313680 

gctcactgca acctctgctt tctgggttca agcaattctt ttgcctcaga caccaagtag 313740 

ctgggattac aggtacatgc caccacgctt tggctaattt ttgtattttt agtagagatg 313800 

aggtttcacc atgttggcca ggctggcctt gaacacttaa cctcaggtga tctgccctcc 313860 

tcagcctccc aaaatgctga gattctagga gtgagccaca gctctggagc taaagcttct 313920 

taaatagaga gctgtgtcac acagaaaatg ccccatgggc agcaagtcat gtttctagga 313980 

ggctttatta ggtgataatt gcgcagatat cgatggcatg cttttttgtt gttgttagca 314040 

tccagaagaa aaaaaaaatc tacaagaggg gttgagcaaa gggacctgaa ttcgggaaaa 314100 

ttaagtgtaa gaatgcataa aatttaaagt aagttttact gaagcttttg tgctcagaga 314160 

gatatgtgtg gttagattcc ctctcaaagc caaacattat ctcctaatta tggccttaac 314220 

aaataacact agtatataac aacaatgaca agttaaaaaa aaaaacaaga cctagtttat 314280 

tttgagatct aaagtcaaaa actagtccta tttagtgcca ataggactag caatgttgtc 314340 

tacaatttgt gaagggaggt tctaataatg ctacttttat tttttaaaat ggtgatagaa 314400 

gaatgctaag catttcatgc ctataaacaa ggcactgaaa atgaaaggta aggtaagata 314460 

atgtcagcag ttaattaagg atggctttta atcttttctt tgatttttct tttcttttcc 314520 

tttagcctta aaaaattcca aactataaca aggagaggaa aaagccagca gaaggagagg 314580 

aagagggact cactatgatg gagtatcagc attggaagag tgggaagaac agacgggttg 314640 

gaaatcagaa gacatggcac ttgcttcctg ggcacagaga ttttggggaa ggatgcttac 314700 

tgtctttgta tacccatttt cttagctgta atatataaat aacaatatta gacagtgtga 314760 

tgaacaccct tgcaaactgt cacacactat acaaacagca gttattatcc acacacctag 314820 

agcccttgta aactgtcaca cgctatacag actgcagtta tcattatcca cacacctaga 314880 

gtgaacacgg tgaaaaacct ttgccttaag ggaagtgggt tagaacctct accacatcac 314940 

tgggccacat tacccagtca cagatgaaca actaggccac tctgcaggtt gtcccacaga 315000 

agcttctaaa atagagatgt gtcacacaga aaatgcccca ggagctgcaa gtcatgttgc 315060 

tgggaggctt tcttaggtga taattgggca aatatttttt gttactttta acagccagaa 315120 

aaaaatgtac aagagaggtt gagcaacaag atctgaaggc aggaaaatta agagtgcctt 315180 

gtgtgtaaag cctaaaaaga gaatgctgta gataagaaat tgagaaatac cacaaaatgc 315240 

ccacagggta caaggaacac tcccttttca cctcccatct gagctgcaat gcccatccga 315300 

gtgctgaata ctgactggaa ataaggcacg gtgatgcatc attctgttag atgtgcagcc 315360 

tccctgcttt tgtccacttc cctcacaaaa atactgattt caaacgccac ttgtcctctt 315420 

agtcttagta tctattttta actatacctg gagaagttct ctaattttga catctgaaat 315480 

catattttcc ccatattaat tctctctctc ttcttcccac aagaatataa gaaccaagaa 315540 

gccgtgaatt taaagaatgt atctctactg cctagaacag tgacatattg taggcattga 315600 

agaaatgtgt tgatgagtga ataaatgaag aaagtgatga aagacttagt tactaagcag 315660 

ctacaaataa tttacaaaaa ggaaatatta tgatcttatt atttccaaca tacatagatt 315720 

cagatgatat aaaacatttg ttttcccaaa aagtccctac taatgtctct tggtggatag 315780 

ttagcagtct ctttgaagtc tggtctccag tgtcttttct cccatttctt cctcctccca 315840 

cctttccttt ggtcttttat tcccttctat tcttccttgc ttcatcacct aatccacagt 315900 

ctcatttctg tcctggagag gagctccatc ttagatggta ggttttactt tccacctagg 315960 

agtagattca agtgttcaaa gtcttaaggg aggaacatct ataagaaaag caactcttgc 316020 

taaattaatt atacttccat agcagagttt ccatagcata ttatgctagt gaagtctcta 316080 

ttgctttcgt tttcctgtca tagatgagga agacaaggga aaaaagacaa ggctagaaac 316140 

tagtgcagaa aattccattg tgcaacaaga gctcacctta tggagatggc aactcaagaa 316200 

ctctacaaag ttttctaaaa ctgcttctca aagtttaatg cacacaacaa ttacctgaga 316260 

tcttgttagc aaattttgtt tcagtagttc tggggtgaag cttcaagttc tgcatttcta 316320 

ataaacaacc aggtggtcca tgggtccaca ccttgagtag tcaatctcta aaagaaaacg 316380 

tttcattttg gacctctact ttacagtcta ctgaaagtag tctactttgc attatggtct 316440 

actgaaaata cactgtgtaa gggaaagagc aagaggattt gggttcatct aggactgggt 316500 

ttgaaatctg gctccgctat tccttaagag acactgggca aggattattt ttaaaaatat 316560 

aaatttccta agcttcagta tcatctggaa tatgggtata ataatatctg tcttatagga 316620 

ttgctataaa aattaacttc ttttaaggaa ctttagcatg gggcaaagct tgatcccttc 316680 

ccctttcttt tcccatttca aattcttcaa aatggcccga ttcagcttca aattctgttt 316740 

caaattttgt ctatttctat tcttgaaaac tgaaagcata tacacccaga cagcttactg 316800 

tctatattaa cacaatttaa cttttcaacc tgtgcattaa cctgacttaa ttattccagg 316860 

aaatccttgc ccaggaagat ggagttgcaa ataactgctt atttcagaat cttcaaaatt 316920 

tatttatctg aaaaatcaat tcattctctt taagtaaata gcctcttctc gaaacaatag 316980 

attattaagc tgggcccaac aaatgattat ttactcttaa agactcttca gtgtactccc 317040 

tttactgtgt ccattaatta tacattatta tattataaca tctttcagta ccaatcagac 317100 

cacttcactg aaagacatgc cttaaagtag actctaaatc tttacaaatg ccagttttga 317160 

ttcttccctt gcaaaacacc actaagactc caccaaggta gtcagtggat tcccttacta 317220 

cagtaagaaa taaacttctc tttgcttgat caaacatgtg attttgctgg tgtcttgaga 317280 

gttggcagtt gacaatctct tctaataaaa ctatcatcca gacaaacata cttaattact 317340 

tatttcctgg aggtggcatg ctttttaata ttccatgctt ttgcacaatc aatttctttt 317400 

ttcctggaat atcatctttt atttaacctt caagactcat actaaatgtt agtctctctg 317460 

tgaaatattt attgaaaccc tttagcaata tagatttttt catgcttctg ttctcccata 317520 

gcattgagta ggccttttcc atcataccct attatttcct gattgcttgg ttacacattt 317580 

ttctttccca aacacaatgt gctctttaaa aatagggact atgccttatc cacctttgtc 317640 

accaatgtct taaagaattt taaaaaaaac tattagttga tcaataaata tttgttgaat 317700 

gttgaatgaa acacagttag cctggatatt tagaggaaga aaaatgggta aataaatatt 317760 

tgttaagaga aacttgagct tcttttcata aggatttcct ttgcatcttc ttaccctttt 317820 

tgttttaggt aatcctgaga aatgttacct ctgaagtcta ctacccctga aatagtagct 317880 

ctctgagcca gcaaaatagg acctttttga tgtctcaaat cctgtcaaaa aggtgatttc 317940 

tcatttcttt ctcatctagt aattattgat ggcaagtatg agcatgcagt tgggtcagtc 318000 

cttctatcag ggtagcagat aacttttatt cccccttcag ggaaatttta cctcctctgg 318060 

catcagtctg gatataaatg ttgctggttt catgatctga aattaagagt gaacattttg 318120 

tttagcccaa tcaaggctgg tagaaggaca aacttttata atgtgaaatt tatgaccctg 318180 

tgatggctga taaaaacaat ccctggcata gttatgcttc tatttaagtg ttaattatcc 318240 

cctatgcaca gtgtgtactc tttttgatag ccacaattca acacttaggc tattaaaggc 318300 

agatttatgc tatagcaata gaatattttt tatttccatc taaactgaaa tctagaagtt 318360 

ccataaaagt gtaagagctc atgtcatggc taacaggttt tgacaagagc taagttaata 318420 

tttgtagcag taaaccatct cctggttgac agtttgttga gacatcagag aagtctctga 318480 

ggagaaaaat taagtaaatc taaatggtac atttgaccaa ctataagcct ggactgacat 318540 

tttgctctag caaaagtaag ctgtttggaa aagagtgcaa aattatatgt atcatatctc 318600 

agtttctgat cattttagat catttgaggt ataaatattt aataaatatg tttaatgttc 318660 

agcagtatgt gaacactact ttcatatctc tctctttttg gctgtcatca aaaaatgaaa 318720 

gaaataacct tcattataac ataagctagt tagccctctg agtactccat gtaacattcg 318780 

cttcatacca taataacaat aagcattgta acatatttgt gtgaagtccc aatgatcttg 318840 

atatctggga ggcttgtgtt aatcagattt tttcaggaat gtaggtagca accataatat 318900 

ttcattgtaa gtttattgta atttttgcca ttatcatgct tgacgtgtgt gatccttaag 318960 

tactcctgtg aagtattaat gtacccatct tacagaggag aaggggactc aaacagaaga 319020 

cgtgcctttt cgtaggtcac acagaacatg gcagagctag agccagaact cagaactcct 319080 

gtctcccaga aacagtcccc tttgttctac aatacacaga tctctgttaa tatattttaa 319140 

aatgattata gaagagatgt tacagaccct tcacatagaa tttgatcaat gtttattttg 319200 

aggcaagtga actaagacag cattaatttt aattgcattc tccatttgag aacagtaatc 319260 

atgaaaagaa attaaaaggc tgagttcaag atcgattttc cagtctttgt agcaatccct 319320 

gaagcttcaa aaagcttgca gaaagacttt ttccagagac tgttttgact tcctcatatt 319380 

agactattaa cgaccatact tagtactcag tagaatatta ataatactgt gcttgaactg 319440 

agacaatttt tctgtgggta cttctacatt ttgaagagta tcaggacaaa tatgtgccca 319500 

tgcagggcat aacacaaatt gatgaagttg attggtagtt ttcaagcact agtatgtgcc 319560 

aggaactatg ctggacactt attttatata taatttttca attaatgttc ataacaatcc 319620 

tacatccatt tcatgggtat aaaaacagac tcagtggagt taaggaacct gtcaaaattc 319680 

acaagatgtt acataactga gtcaacattt gaacctgggt ctatccaatt tcaataattc 319740 

cacttcagta tgatgtttag ttcttttcaa actcacaaca aaggaaaaaa tctttgccta 319800 

gtcaggtggg gcctacattt aacccggata acctacattt ggaacgtggg agaaatgcaa 319860 

tttctgtttc cccgttctct cttccacatc tctttctaca cttgctggct actatttctc 319920 

actctttcac cccttccaga gactgaccag aagaaagaag ccattagaga aaaagaacac 319980 

cattgtacat gcccaacaca attgcaatcc agtataagag gctcccctgg atttgaatga 320040 

tgtccagagc tgacctgttc taccatgaga ctctttagtt gttctttgta gatctgtcca 320100 

gtgggggtct tttctatacc atcctagata cagaaaatgt ctccctgctg ccggccactt 320160 

accctgcccc accatcagcc cttaggtttt cagtggtcca gaagctaatg gatcttcttt 320220 

gactctccag ccagtcctct taaaagcttc tattcttgga gtcctctttt gatttccaag 320280 

aaacacatta gctcccagtt tgctctgcct ggtgaaaatg cagctcactc tcaatgcaac 320340 

catttttatc ctgttgtcag cagacacagc tgcagccaca gcctcttgtc tttcattttc 320400 

ctctcaggct tcagatgtta ttgaattggt tttgtagctt tcttcctttg acctattgtt 320460 

aaatacatta cataagtaga attcataata ctaatttttt tgtatatgag gaataaattc 320520 

tacctgtttt tcatgtagtt ttttttaaga atctatttgc taatatctcc ttttgtagct 320580 

ttgtgtctct gctcataatt agagaataat tgattagtac tattttttgg ttagattttg 320640 

ctaactttct aaaattatgt agaaatgatc ccatctgatt ccatgctctg gaaaatttct 320700 

ataaaatgga aggcaacatc tccttggata ttttaaacac tttctcataa aactcactat 320760 

gttaagtgtg atcaatagtc attaatagta taattcttag tgtttctctt tgtattatta 320820 

tatttaattt ctattgcttg atttatcagt ttttaaagat acatgtgatt cccagttatt 320880 

gcaacagatg aggcaacaat aacaataatg gagtgtaatc tattgttatg tactctgata 320940 

atgcaataat gtcaaactaa caagtaaatg gaagcagagg ggggagacaa aaggaaaagt 321000 

agagaaaata ggaattagcc aaacacacac aaaaaaaaac atgtccaaca tcattagtaa 321060 

tctgaaaagt acaaaacaaa ctcacaatga gatagtattt tatatgcacc aaattggaaa 321120 

atctgaaaat atctgataat attatgttag gccaggcaca gtggcatgca cctgtagttc 321180 

cagctgcttc agaggctaaa gcaagaaaat catttgagcc caggagttca aggctattgt 321240 

gcactatgat catgtgtatg agtagtcact gcactctagc ctggacaaca taatgagact 321300 

gtctctaaaa aaaattaaaa ataaaaataa aaatactcag tgttggcatg gatatgaaac 321360 

aactagacat ctatgtcttt gggtaaaaat gtaaattggt acgctttgta acaatactta 321420 

agtcttttta tggggatgta aatcaatata aaatgataac aacaacttat tttttaaatc 321480 

acaaatgcac tcattctatg acacagggat taagctccca caactattcc atagagaaac 321540 

ccttgcacat ataaatggat agaaatgcca tacaaaatac tcaaagcaac atactttgta 321600 

atatcacaaa actagtgata tagtttggat gtctgtctcc tccaaatcac acgttgaaat 321660 

gtgactccta atgttgaagg tggggcccag taggaggtgt ttgggtgatg ggagtggatc 321720 

cctcatgaat tgcttagtgc cctccctgca gtaatgtgtg agttttcact ctattcacaa 321780 

gagctggttg tttaaaatga gactggcacc tcctcctctc tctcgtgctt tctttcttgc 321840 

catgtgacac acctgctccc ccttcacctt ctgctatgat tggaagcttc ctgaggctct 321900 

tatcagaagc agattctggg gccatgtttc ttgtacagtc tgcagaacca tgagccaaat 321960 

aaacatattt tctttagaaa ttacccagcc tcaggtattc ctgtatagca atgcaaaatg 322020 

gactaatata actagaaaca actcaaatgt taattaatgg aagaaagact aaaaaatatt 322080 

gtatataaca ctatatatta t                                           322101 

 
           
             2  
             897  
             DNA  
             Homo sapiens  
           
            2 

atg aag gag acc cgg ggc tac gga ggg gat gcc ccc ttc tgc acc cgc       48 

ctc aac cac tcc tac aca ggc atg tgg gcg ccc gag cgt tcc gcc gag       96 

gcg cgg ggc aac ctc acg cgc cct cca ggg tct ggc gag gat tgc gga      144 

tcg gtg tcc gtg gcc ttc ccg atc acc atg ctg ctc act ggt ttc gtg      192 

ggc aac gca ctg gcc atg ctg ctc gtg tcg cgc agc tac cgg cgc cgg      240 

gag agc aag cgc aag aag tcc ttc ctg ctg tgc atc ggc tgg ctg gcg      288 

ctc acc gac ctg gtc ggg cag ctt ctc acc acc ccg gtc gtc atc gtc      336 

gtg tac ctg tcc aag cag cgt tgg gag cac atc gac ccg tcg ggg cgg      384 

ctc tgc acc ttt ttc ggg ctg acc atg act gtt ttc ggg ctc tcc tcg      432 

ttg ttc atc gcc agc gcc atg gcc gtc gag cgg gcg ctg gcc atc agg      480 

gcg ccg cac tgg tat gcg agc cac atg aag acg cgt gcc acc cgc gct      528 

gtg ctg ctc ggc gtg tgg ctg gcc gtg ctc gcc ttc gcc ctg ctg ccg      576 

gtg ctg ggc gtg ggc cag tac acc gtc cag tgg ccc ggg acg tgg tgc      624 

ttc atc agc acc ggg cga ggg ggc aac ggg act agc tct tcg cat aac      672 

tgg ggc aac ctt ttc ttc gcc tct gcc ttt gcc ttc ctg ggg ctc ttg      720 

gcg ctg aca gtc acc ttt tcc tgc aac ctg gcc acc att aag gcc ctg      768 

gtg tcc cgc tgc cgg gcc aag gcc acg gca tct cag tcc agt gcc cag      816 

tgg ggc cgc atc acg acc gag acg gcc att cag ctt atg ggg atc atg      864 

tgc gtg ctg tcg gtc tgc tgg tct ccg ctc ctg                          897 

 
           
             3  
             180  
             DNA  
             Homo sapiens  
           
            3 

ata atg atg ttg aaa atg atc ttc aat cag aca tca gtt gag cac tgc       48 

aag aca cac acg gag aag cag aaa gaa tgc aac ttc ttc tta ata gct       96 

gtt cgc ctg gct tca ctg aac cag atc ttg gat cct tgg gtt tac ctg      144 

ctg tta aga aag atc ctt ctt cga aag ttt tgc cag                      180 

 
           
             4  
             90  
             DNA  
             Homo sapiens  
           
            4 

gta gca aat gct gtc tcc agc tgc tct aat gat gga cag aaa ggg cag       48 

cct atc tca tta tct aat gaa ata ata cag aca gaa gca tga               90 

 
           
             5  
             225  
             DNA  
             Homo sapiens  
           
            5 

aag tgt tcc cca gtc ttt gac tct tta aat tcc aat act gat tcc aaa       48 

aca aat aaa tat ttt gaa gac tca atg aat act ttc cat att ttg gcc       96 

tat tta tat aag aaa gtt aat aac att gac cct tca cag ctc ttc tgc      144 

ctg ctc ctc aaa gtg gct cta tct aaa tat tta tta cta aaa tgt ttt      192 

tcc tac agt cta cat gaa tac aaa cct caa tag                          225 

 
           
             6  
             147  
             DNA  
             Homo sapiens  
           
            6 

gat act cat gtg ggt ggg gca gag aac ata gaa aaa gat atg atg gaa       48 

aac ctg tcc att ttc tac ctg tta acc ttc atc att ttg tgc cag gcc       96 

ctg gaa gca aag aga gga agg gac cga ctg cat tta tct ttg aac act      144 

tga                                                                  147 

 
           
             7  
             96  
             DNA  
             Homo sapiens  
           
            7 

atc agg tac cac aca aac aac tat gca tcc agc tcc acc tcc tta ccc       48 

tgc cag tgt tcc tca acc ttg atg tgg agc gac cat ttg gaa agg tga       96 

 
           
             8  
             99  
             DNA  
             Homo sapiens  
           
            8 

atc agg tac cac aca aac aac tat gca tcc agc tcc acc tcc tta ccc       48 

tgc cag tgt tcc tca acc ttg atg tgg agc gac cat ttg gaa aga taa       96 

tga                                                                   99 

 
           
             9  
             27  
             DNA  
             Homo sapiens  
           
            9 

atg aga aaa aga aga ctc aga gag caa                                   27 

 
           
             10  
             78  
             DNA  
             Homo sapiens  
           
            10 

tta atc tgc agt ttg cga act ctc aga tac aga ggg caa ctg cac att       48 

gtg ggc aag tac aaa cct atc gtg tgc tga                               78 

 
           
             11  
             76  
             DNA  
             Homo sapiens  
           
            11 

gag atg ggg cct gat gga agg tgt ttt tgt cat gca tgg agg cag gtc       48 

ccc agg act tgg tgc agt tct cat gat a                                 76 

 
           
             12  
             145  
             DNA  
             Homo sapiens  
           
            12 

gct cct ctt ctt ccc acc tct act gtg att gat cct tca agg ttc tgt       48 

gct cag ccc ttc cgt tgg ttc ttg gat ttg tcc ttt ccc gcc atg tct       96 

tca tca cat cca caa ctt cca cta aca ctt gcg agc ttc aaa ctt ctt      144 

a                                                                    145 

 
           
             13  
             32  
             DNA  
             Homo sapiens  
           
            13 

gag aac cct gca gtg tcc agc taa gct gat ga                            32 

 
           
             14  
             21  
             DNA  
             Homo sapiens  
           
            14 

gag gaa ttt tgg gga aat taa                                           21 

 
           
             15  
             1167  
             DNA  
             Homo sapiens  
             
               CDS  
               (1)...(1164)  
               cDNA  
             
           
            15 

atg aag gag acc cgg ggc tac gga ggg gat gcc ccc ttc tgc acc cgc       48 
Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                   10                  15 

ctc aac cac tcc tac aca ggc atg tgg gcg ccc gag cgt tcc gcc gag       96 
Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
             20                  25                  30 

gcg cgg ggc aac ctc acg cgc cct cca ggg tct ggc gag gat tgc gga      144 
Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
         35                  40                  45 

tcg gtg tcc gtg gcc ttc ccg atc acc atg ctg ctc act ggt ttc gtg      192 
Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
     50                  55                  60 

ggc aac gca ctg gcc atg ctg ctc gtg tcg cgc agc tac cgg cgc cgg      240 
Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
 65                  70                  75                  80 

gag agc aag cgc aag aag tcc ttc ctg ctg tgc atc ggc tgg ctg gcg      288 
Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                 85                  90                  95 

ctc acc gac ctg gtc ggg cag ctt ctc acc acc ccg gtc gtc atc gtc      336 
Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

gtg tac ctg tcc aag cag cgt tgg gag cac atc gac ccg tcg ggg cgg      384 
Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

ctc tgc acc ttt ttc ggg ctg acc atg act gtt ttc ggg ctc tcc tcg      432 
Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

ttg ttc atc gcc agc gcc atg gcc gtc gag cgg gcg ctg gcc atc agg      480 
Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

gcg ccg cac tgg tat gcg agc cac atg aag acg cgt gcc acc cgc gct      528 
Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

gtg ctg ctc ggc gtg tgg ctg gcc gtg ctc gcc ttc gcc ctg ctg ccg      576 
Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

gtg ctg ggc gtg ggc cag tac acc gtc cag tgg ccc ggg acg tgg tgc      624 
Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

ttc atc agc acc ggg cga ggg ggc aac ggg act agc tct tcg cat aac      672 
Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

tgg ggc aac ctt ttc ttc gcc tct gcc ttt gcc ttc ctg ggg ctc ttg      720 
Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

gcg ctg aca gtc acc ttt tcc tgc aac ctg gcc acc att aag gcc ctg      768 
Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

gtg tcc cgc tgc cgg gcc aag gcc acg gca tct cag tcc agt gcc cag      816 
Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

tgg ggc cgc atc acg acc gag acg gcc att cag ctt atg ggg atc atg      864 
Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

tgc gtg ctg tcg gtc tgc tgg tct ccg ctc ctg ata atg atg ttg aaa      912 
Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

atg atc ttc aat cag aca tca gtt gag cac tgc aag aca cac acg gag      960 
Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

aag cag aaa gaa tgc aac ttc ttc tta ata gct gtt cgc ctg gct tca     1008 
Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

ctg aac cag atc ttg gat cct tgg gtt tac ctg ctg tta aga aag atc     1056 
Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

ctt ctt cga aag ttt tgc cag gta gca aat gct gtc tcc agc tgc tct     1104 
Leu Leu Arg Lys Phe Cys Gln Val Ala Asn Ala Val Ser Ser Cys Ser 
        355                 360                 365 

aat gat gga cag aaa ggg cag cct atc tca tta tct aat gaa ata ata     1152 
Asn Asp Gly Gln Lys Gly Gln Pro Ile Ser Leu Ser Asn Glu Ile Ile 
    370                 375                 380 

cag aca gaa gca tga                                                 1167 
Gln Thr Glu Ala 
385 

 
           
             16  
             388  
             PRT  
             Homo sapiens  
           
            16 

Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                  10                  15 

Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
            20                  25                  30 

Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
        35                  40                  45 

Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
    50                  55                  60 

Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
65                  70                  75                  80 

Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                85                  90                  95 

Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

Leu Leu Arg Lys Phe Cys Gln Val Ala Asn Ala Val Ser Ser Cys Ser 
        355                 360                 365 

Asn Asp Gly Gln Lys Gly Gln Pro Ile Ser Leu Ser Asn Glu Ile Ile 
    370                 375                 380 

Gln Thr Glu Ala 
385 

 
           
             17  
             1224  
             DNA  
             Homo sapiens  
             
               CDS  
               (1)...(1221)  
               cDNA  
             
           
            17 

atg aag gag acc cgg ggc tac gga ggg gat gcc ccc ttc tgc acc cgc       48 
Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                   10                  15 

ctc aac cac tcc tac aca ggc atg tgg gcg ccc gag cgt tcc gcc gag       96 
Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
             20                  25                  30 

gcg cgg ggc aac ctc acg cgc cct cca ggg tct ggc gag gat tgc gga      144 
Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
         35                  40                  45 

tcg gtg tcc gtg gcc ttc ccg atc acc atg ctg ctc act ggt ttc gtg      192 
Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
     50                  55                  60 

ggc aac gca ctg gcc atg ctg ctc gtg tcg cgc agc tac cgg cgc cgg      240 
Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
 65                  70                  75                  80 

gag agc aag cgc aag aag tcc ttc ctg ctg tgc atc ggc tgg ctg gcg      288 
Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                 85                  90                  95 

ctc acc gac ctg gtc ggg cag ctt ctc acc acc ccg gtc gtc atc gtc      336 
Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

gtg tac ctg tcc aag cag cgt tgg gag cac atc gac ccg tcg ggg cgg      384 
Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

ctc tgc acc ttt ttc ggg ctg acc atg act gtt ttc ggg ctc tcc tcg      432 
Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

ttg ttc atc gcc agc gcc atg gcc gtc gag cgg gcg ctg gcc atc agg      480 
Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

gcg ccg cac tgg tat gcg agc cac atg aag acg cgt gcc acc cgc gct      528 
Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

gtg ctg ctc ggc gtg tgg ctg gcc gtg ctc gcc ttc gcc ctg ctg ccg      576 
Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

gtg ctg ggc gtg ggc cag tac acc gtc cag tgg ccc ggg acg tgg tgc      624 
Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

ttc atc agc acc ggg cga ggg ggc aac ggg act agc tct tcg cat aac      672 
Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

tgg ggc aac ctt ttc ttc gcc tct gcc ttt gcc ttc ctg ggg ctc ttg      720 
Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

gcg ctg aca gtc acc ttt tcc tgc aac ctg gcc acc att aag gcc ctg      768 
Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

gtg tcc cgc tgc cgg gcc aag gcc acg gca tct cag tcc agt gcc cag      816 
Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

tgg ggc cgc atc acg acc gag acg gcc att cag ctt atg ggg atc atg      864 
Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

tgc gtg ctg tcg gtc tgc tgg tct ccg ctc ctg ata atg atg ttg aaa      912 
Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

atg atc ttc aat cag aca tca gtt gag cac tgc aag aca cac acg gag      960 
Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

aag cag aaa gaa tgc aac ttc ttc tta ata gct gtt cgc ctg gct tca     1008 
Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

ctg aac cag atc ttg gat cct tgg gtt tac ctg ctg tta aga aag atc     1056 
Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

ctt ctt cga aag ttt tgc cag gat act cat gtg ggt ggg gca gag aac     1104 
Leu Leu Arg Lys Phe Cys Gln Asp Thr His Val Gly Gly Ala Glu Asn 
        355                 360                 365 

ata gaa aaa gat atg atg gaa aac ctg tcc att ttc tac ctg tta acc     1152 
Ile Glu Lys Asp Met Met Glu Asn Leu Ser Ile Phe Tyr Leu Leu Thr 
    370                 375                 380 

ttc atc att ttg tgc cag gcc ctg gaa gca aag aga gga agg gac cga     1200 
Phe Ile Ile Leu Cys Gln Ala Leu Glu Ala Lys Arg Gly Arg Asp Arg 
385                 390                 395                 400 

ctg cat tta tct ttg aac act tga                                     1224 
Leu His Leu Ser Leu Asn Thr 
                405 

 
           
             18  
             407  
             PRT  
             Homo sapiens  
           
            18 

Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                  10                  15 

Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
            20                  25                  30 

Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
        35                  40                  45 

Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
    50                  55                  60 

Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
65                  70                  75                  80 

Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                85                  90                  95 

Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

Leu Leu Arg Lys Phe Cys Gln Asp Thr His Val Gly Gly Ala Glu Asn 
        355                 360                 365 

Ile Glu Lys Asp Met Met Glu Asn Leu Ser Ile Phe Tyr Leu Leu Thr 
    370                 375                 380 

Phe Ile Ile Leu Cys Gln Ala Leu Glu Ala Lys Arg Gly Arg Asp Arg 
385                 390                 395                 400 

Leu His Leu Ser Leu Asn Thr 
                405 

 
           
             19  
             1302  
             DNA  
             Homo sapiens  
             
               CDS  
               (1)...(1299)  
               cDNA  
             
           
            19 

atg aag gag acc cgg ggc tac gga ggg gat gcc ccc ttc tgc acc cgc       48 
Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                   10                  15 

ctc aac cac tcc tac aca ggc atg tgg gcg ccc gag cgt tcc gcc gag       96 
Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
             20                  25                  30 

gcg cgg ggc aac ctc acg cgc cct cca ggg tct ggc gag gat tgc gga      144 
Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
         35                  40                  45 

tcg gtg tcc gtg gcc ttc ccg atc acc atg ctg ctc act ggt ttc gtg      192 
Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
     50                  55                  60 

ggc aac gca ctg gcc atg ctg ctc gtg tcg cgc agc tac cgg cgc cgg      240 
Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
 65                  70                  75                  80 

gag agc aag cgc aag aag tcc ttc ctg ctg tgc atc ggc tgg ctg gcg      288 
Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                 85                  90                  95 

ctc acc gac ctg gtc ggg cag ctt ctc acc acc ccg gtc gtc atc gtc      336 
Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

gtg tac ctg tcc aag cag cgt tgg gag cac atc gac ccg tcg ggg cgg      384 
Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

ctc tgc acc ttt ttc ggg ctg acc atg act gtt ttc ggg ctc tcc tcg      432 
Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

ttg ttc atc gcc agc gcc atg gcc gtc gag cgg gcg ctg gcc atc agg      480 
Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

gcg ccg cac tgg tat gcg agc cac atg aag acg cgt gcc acc cgc gct      528 
Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

gtg ctg ctc ggc gtg tgg ctg gcc gtg ctc gcc ttc gcc ctg ctg ccg      576 
Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

gtg ctg ggc gtg ggc cag tac acc gtc cag tgg ccc ggg acg tgg tgc      624 
Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

ttc atc agc acc ggg cga ggg ggc aac ggg act agc tct tcg cat aac      672 
Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

tgg ggc aac ctt ttc ttc gcc tct gcc ttt gcc ttc ctg ggg ctc ttg      720 
Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

gcg ctg aca gtc acc ttt tcc tgc aac ctg gcc acc att aag gcc ctg      768 
Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

gtg tcc cgc tgc cgg gcc aag gcc acg gca tct cag tcc agt gcc cag      816 
Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

tgg ggc cgc atc acg acc gag acg gcc att cag ctt atg ggg atc atg      864 
Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

tgc gtg ctg tcg gtc tgc tgg tct ccg ctc ctg ata atg atg ttg aaa      912 
Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

atg atc ttc aat cag aca tca gtt gag cac tgc aag aca cac acg gag      960 
Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

aag cag aaa gaa tgc aac ttc ttc tta ata gct gtt cgc ctg gct tca     1008 
Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

ctg aac cag atc ttg gat cct tgg gtt tac ctg ctg tta aga aag atc     1056 
Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

ctt ctt cga aag ttt tgc cag aag tgt tcc cca gtc ttt gac tct tta     1104 
Leu Leu Arg Lys Phe Cys Gln Lys Cys Ser Pro Val Phe Asp Ser Leu 
        355                 360                 365 

aat tcc aat act gat tcc aaa aca aat aaa tat ttt gaa gac tca atg     1152 
Asn Ser Asn Thr Asp Ser Lys Thr Asn Lys Tyr Phe Glu Asp Ser Met 
    370                 375                 380 

aat act ttc cat att ttg gcc tat tta tat aag aaa gtt aat aac att     1200 
Asn Thr Phe His Ile Leu Ala Tyr Leu Tyr Lys Lys Val Asn Asn Ile 
385                 390                 395                 400 

gac cct tca cag ctc ttc tgc ctg ctc ctc aaa gtg gct cta tct aaa     1248 
Asp Pro Ser Gln Leu Phe Cys Leu Leu Leu Lys Val Ala Leu Ser Lys 
                405                 410                 415 

tat tta tta cta aaa tgt ttt tcc tac agt cta cat gaa tac aaa cct     1296 
Tyr Leu Leu Leu Lys Cys Phe Ser Tyr Ser Leu His Glu Tyr Lys Pro 
            420                 425                 430 

caa tag                                                             1302 
Gln 

 
           
             20  
             433  
             PRT  
             Homo sapiens  
           
            20 

Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                  10                  15 

Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
            20                  25                  30 

Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
        35                  40                  45 

Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
    50                  55                  60 

Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
65                  70                  75                  80 

Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                85                  90                  95 

Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

Leu Leu Arg Lys Phe Cys Gln Lys Cys Ser Pro Val Phe Asp Ser Leu 
        355                 360                 365 

Asn Ser Asn Thr Asp Ser Lys Thr Asn Lys Tyr Phe Glu Asp Ser Met 
    370                 375                 380 

Asn Thr Phe His Ile Leu Ala Tyr Leu Tyr Lys Lys Val Asn Asn Ile 
385                 390                 395                 400 

Asp Pro Ser Gln Leu Phe Cys Leu Leu Leu Lys Val Ala Leu Ser Lys 
                405                 410                 415 

Tyr Leu Leu Leu Lys Cys Phe Ser Tyr Ser Leu His Glu Tyr Lys Pro 
            420                 425                 430 

Gln 

 
           
             21  
             1173  
             DNA  
             Homo sapiens  
             
               CDS  
               (1)...(1170)  
               cDNA  
             
           
            21 

atg aag gag acc cgg ggc tac gga ggg gat gcc ccc ttc tgc acc cgc       48 
Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                   10                  15 

ctc aac cac tcc tac aca ggc atg tgg gcg ccc gag cgt tcc gcc gag       96 
Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
             20                  25                  30 

gcg cgg ggc aac ctc acg cgc cct cca ggg tct ggc gag gat tgc gga      144 
Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
         35                  40                  45 

tcg gtg tcc gtg gcc ttc ccg atc acc atg ctg ctc act ggt ttc gtg      192 
Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
     50                  55                  60 

ggc aac gca ctg gcc atg ctg ctc gtg tcg cgc agc tac cgg cgc cgg      240 
Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
 65                  70                  75                  80 

gag agc aag cgc aag aag tcc ttc ctg ctg tgc atc ggc tgg ctg gcg      288 
Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                 85                  90                  95 

ctc acc gac ctg gtc ggg cag ctt ctc acc acc ccg gtc gtc atc gtc      336 
Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

gtg tac ctg tcc aag cag cgt tgg gag cac atc gac ccg tcg ggg cgg      384 
Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

ctc tgc acc ttt ttc ggg ctg acc atg act gtt ttc ggg ctc tcc tcg      432 
Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

ttg ttc atc gcc agc gcc atg gcc gtc gag cgg gcg ctg gcc atc agg      480 
Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

gcg ccg cac tgg tat gcg agc cac atg aag acg cgt gcc acc cgc gct      528 
Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

gtg ctg ctc ggc gtg tgg ctg gcc gtg ctc gcc ttc gcc ctg ctg ccg      576 
Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

gtg ctg ggc gtg ggc cag tac acc gtc cag tgg ccc ggg acg tgg tgc      624 
Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

ttc atc agc acc ggg cga ggg ggc aac ggg act agc tct tcg cat aac      672 
Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

tgg ggc aac ctt ttc ttc gcc tct gcc ttt gcc ttc ctg ggg ctc ttg      720 
Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

gcg ctg aca gtc acc ttt tcc tgc aac ctg gcc acc att aag gcc ctg      768 
Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

gtg tcc cgc tgc cgg gcc aag gcc acg gca tct cag tcc agt gcc cag      816 
Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

tgg ggc cgc atc acg acc gag acg gcc att cag ctt atg ggg atc atg      864 
Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

tgc gtg ctg tcg gtc tgc tgg tct ccg ctc ctg ata atg atg ttg aaa      912 
Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

atg atc ttc aat cag aca tca gtt gag cac tgc aag aca cac acg gag      960 
Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

aag cag aaa gaa tgc aac ttc ttc tta ata gct gtt cgc ctg gct tca     1008 
Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

ctg aac cag atc ttg gat cct tgg gtt tac ctg ctg tta aga aag atc     1056 
Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

ctt ctt cga aag ttt tgc cag atc agg tac cac aca aac aac tat gca     1104 
Leu Leu Arg Lys Phe Cys Gln Ile Arg Tyr His Thr Asn Asn Tyr Ala 
        355                 360                 365 

tcc agc tcc acc tcc tta ccc tgc cag tgt tcc tca acc ttg atg tgg     1152 
Ser Ser Ser Thr Ser Leu Pro Cys Gln Cys Ser Ser Thr Leu Met Trp 
    370                 375                 380 

agc gac cat ttg gaa agg tga                                         1173 
Ser Asp His Leu Glu Arg 
385                 390 

 
           
             22  
             390  
             PRT  
             Homo sapiens  
           
            22 

Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                  10                  15 

Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
            20                  25                  30 

Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
        35                  40                  45 

Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
    50                  55                  60 

Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
65                  70                  75                  80 

Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                85                  90                  95 

Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

Leu Leu Arg Lys Phe Cys Gln Ile Arg Tyr His Thr Asn Asn Tyr Ala 
        355                 360                 365 

Ser Ser Ser Thr Ser Leu Pro Cys Gln Cys Ser Ser Thr Leu Met Trp 
    370                 375                 380 

Ser Asp His Leu Glu Arg 
385                 390 

 
           
             23  
             1176  
             DNA  
             Homo sapiens  
             
               CDS  
               (1)...(1170)  
               cDNA  
             
           
            23 

atg aag gag acc cgg ggc tac gga ggg gat gcc ccc ttc tgc acc cgc       48 
Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                   10                  15 

ctc aac cac tcc tac aca ggc atg tgg gcg ccc gag cgt tcc gcc gag       96 
Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
             20                  25                  30 

gcg cgg ggc aac ctc acg cgc cct cca ggg tct ggc gag gat tgc gga      144 
Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
         35                  40                  45 

tcg gtg tcc gtg gcc ttc ccg atc acc atg ctg ctc act ggt ttc gtg      192 
Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
     50                  55                  60 

ggc aac gca ctg gcc atg ctg ctc gtg tcg cgc agc tac cgg cgc cgg      240 
Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
 65                  70                  75                  80 

gag agc aag cgc aag aag tcc ttc ctg ctg tgc atc ggc tgg ctg gcg      288 
Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                 85                  90                  95 

ctc acc gac ctg gtc ggg cag ctt ctc acc acc ccg gtc gtc atc gtc      336 
Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

gtg tac ctg tcc aag cag cgt tgg gag cac atc gac ccg tcg ggg cgg      384 
Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

ctc tgc acc ttt ttc ggg ctg acc atg act gtt ttc ggg ctc tcc tcg      432 
Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

ttg ttc atc gcc agc gcc atg gcc gtc gag cgg gcg ctg gcc atc agg      480 
Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

gcg ccg cac tgg tat gcg agc cac atg aag acg cgt gcc acc cgc gct      528 
Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

gtg ctg ctc ggc gtg tgg ctg gcc gtg ctc gcc ttc gcc ctg ctg ccg      576 
Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

gtg ctg ggc gtg ggc cag tac acc gtc cag tgg ccc ggg acg tgg tgc      624 
Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

ttc atc agc acc ggg cga ggg ggc aac ggg act agc tct tcg cat aac      672 
Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

tgg ggc aac ctt ttc ttc gcc tct gcc ttt gcc ttc ctg ggg ctc ttg      720 
Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

gcg ctg aca gtc acc ttt tcc tgc aac ctg gcc acc att aag gcc ctg      768 
Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

gtg tcc cgc tgc cgg gcc aag gcc acg gca tct cag tcc agt gcc cag      816 
Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

tgg ggc cgc atc acg acc gag acg gcc att cag ctt atg ggg atc atg      864 
Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

tgc gtg ctg tcg gtc tgc tgg tct ccg ctc ctg ata atg atg ttg aaa      912 
Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

atg atc ttc aat cag aca tca gtt gag cac tgc aag aca cac acg gag      960 
Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

aag cag aaa gaa tgc aac ttc ttc tta ata gct gtt cgc ctg gct tca     1008 
Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

ctg aac cag atc ttg gat cct tgg gtt tac ctg ctg tta aga aag atc     1056 
Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

ctt ctt cga aag ttt tgc cag atc agg tac cac aca aac aac tat gca     1104 
Leu Leu Arg Lys Phe Cys Gln Ile Arg Tyr His Thr Asn Asn Tyr Ala 
        355                 360                 365 

tcc agc tcc acc tcc tta ccc tgc cag tgt tcc tca acc ttg atg tgg     1152 
Ser Ser Ser Thr Ser Leu Pro Cys Gln Cys Ser Ser Thr Leu Met Trp 
    370                 375                 380 

agc gac cat ttg gaa aga taatga                                      1176 
Ser Asp His Leu Glu Arg 
385                 390 

 
           
             24  
             390  
             PRT  
             Homo sapiens  
           
            24 

Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                  10                  15 

Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
            20                  25                  30 

Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
        35                  40                  45 

Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
    50                  55                  60 

Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
65                  70                  75                  80 

Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                85                  90                  95 

Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

Leu Leu Arg Lys Phe Cys Gln Ile Arg Tyr His Thr Asn Asn Tyr Ala 
        355                 360                 365 

Ser Ser Ser Thr Ser Leu Pro Cys Gln Cys Ser Ser Thr Leu Met Trp 
    370                 375                 380 

Ser Asp His Leu Glu Arg 
385                 390 

 
           
             25  
             1281  
             DNA  
             Homo sapiens  
             
               CDS  
               (1)...(1275)  
               cDNA  
             
           
            25 

atg aag gag acc cgg ggc tac gga ggg gat gcc ccc ttc tgc acc cgc       48 
Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                   10                  15 

ctc aac cac tcc tac aca ggc atg tgg gcg ccc gag cgt tcc gcc gag       96 
Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
             20                  25                  30 

gcg cgg ggc aac ctc acg cgc cct cca ggg tct ggc gag gat tgc gga      144 
Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
         35                  40                  45 

tcg gtg tcc gtg gcc ttc ccg atc acc atg ctg ctc act ggt ttc gtg      192 
Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
     50                  55                  60 

ggc aac gca ctg gcc atg ctg ctc gtg tcg cgc agc tac cgg cgc cgg      240 
Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
 65                  70                  75                  80 

gag agc aag cgc aag aag tcc ttc ctg ctg tgc atc ggc tgg ctg gcg      288 
Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                 85                  90                  95 

ctc acc gac ctg gtc ggg cag ctt ctc acc acc ccg gtc gtc atc gtc      336 
Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

gtg tac ctg tcc aag cag cgt tgg gag cac atc gac ccg tcg ggg cgg      384 
Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

ctc tgc acc ttt ttc ggg ctg acc atg act gtt ttc ggg ctc tcc tcg      432 
Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

ttg ttc atc gcc agc gcc atg gcc gtc gag cgg gcg ctg gcc atc agg      480 
Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

gcg ccg cac tgg tat gcg agc cac atg aag acg cgt gcc acc cgc gct      528 
Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

gtg ctg ctc ggc gtg tgg ctg gcc gtg ctc gcc ttc gcc ctg ctg ccg      576 
Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

gtg ctg ggc gtg ggc cag tac acc gtc cag tgg ccc ggg acg tgg tgc      624 
Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

ttc atc agc acc ggg cga ggg ggc aac ggg act agc tct tcg cat aac      672 
Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

tgg ggc aac ctt ttc ttc gcc tct gcc ttt gcc ttc ctg ggg ctc ttg      720 
Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

gcg ctg aca gtc acc ttt tcc tgc aac ctg gcc acc att aag gcc ctg      768 
Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

gtg tcc cgc tgc cgg gcc aag gcc acg gca tct cag tcc agt gcc cag      816 
Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

tgg ggc cgc atc acg acc gag acg gcc att cag ctt atg ggg atc atg      864 
Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

tgc gtg ctg tcg gtc tgc tgg tct ccg ctc ctg ata atg atg ttg aaa      912 
Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

atg atc ttc aat cag aca tca gtt gag cac tgc aag aca cac acg gag      960 
Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

aag cag aaa gaa tgc aac ttc ttc tta ata gct gtt cgc ctg gct tca     1008 
Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

ctg aac cag atc ttg gat cct tgg gtt tac ctg ctg tta aga aag atc     1056 
Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

ctt ctt cga aag ttt tgc cag atg aga aaa aga aga ctc aga gag caa     1104 
Leu Leu Arg Lys Phe Cys Gln Met Arg Lys Arg Arg Leu Arg Glu Gln 
        355                 360                 365 

gct cct ctt ctt ccc acc tct act gtg att gat cct tca agg ttc tgt     1152 
Ala Pro Leu Leu Pro Thr Ser Thr Val Ile Asp Pro Ser Arg Phe Cys 
    370                 375                 380 

gct cag ccc ttc cgt tgg ttc ttg gat ttg tcc ttt ccc gcc atg tct     1200 
Ala Gln Pro Phe Arg Trp Phe Leu Asp Leu Ser Phe Pro Ala Met Ser 
385                 390                 395                 400 

tca tca cat cca caa ctt cca cta aca ctt gcg agc ttc aaa ctt ctt     1248 
Ser Ser His Pro Gln Leu Pro Leu Thr Leu Ala Ser Phe Lys Leu Leu 
                405                 410                 415 

aga gaa ccc tgc agt gtc cag cta agc tgatga                          1281 
Arg Glu Pro Cys Ser Val Gln Leu Ser 
            420                 425 

 
           
             26  
             425  
             PRT  
             Homo sapiens  
           
            26 

Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                  10                  15 

Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
            20                  25                  30 

Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
        35                  40                  45 

Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
    50                  55                  60 

Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
65                  70                  75                  80 

Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                85                  90                  95 

Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

Leu Leu Arg Lys Phe Cys Gln Met Arg Lys Arg Arg Leu Arg Glu Gln 
        355                 360                 365 

Ala Pro Leu Leu Pro Thr Ser Thr Val Ile Asp Pro Ser Arg Phe Cys 
    370                 375                 380 

Ala Gln Pro Phe Arg Trp Phe Leu Asp Leu Ser Phe Pro Ala Met Ser 
385                 390                 395                 400 

Ser Ser His Pro Gln Leu Pro Leu Thr Leu Ala Ser Phe Lys Leu Leu 
                405                 410                 415 

Arg Glu Pro Cys Ser Val Gln Leu Ser 
            420                 425 

 
           
             27  
             1182  
             DNA  
             Homo sapiens  
             
               CDS  
               (1)...(1179)  
               cDNA  
             
           
            27 

atg aag gag acc cgg ggc tac gga ggg gat gcc ccc ttc tgc acc cgc       48 
Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                   10                  15 

ctc aac cac tcc tac aca ggc atg tgg gcg ccc gag cgt tcc gcc gag       96 
Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
             20                  25                  30 

gcg cgg ggc aac ctc acg cgc cct cca ggg tct ggc gag gat tgc gga      144 
Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
         35                  40                  45 

tcg gtg tcc gtg gcc ttc ccg atc acc atg ctg ctc act ggt ttc gtg      192 
Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
     50                  55                  60 

ggc aac gca ctg gcc atg ctg ctc gtg tcg cgc agc tac cgg cgc cgg      240 
Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
 65                  70                  75                  80 

gag agc aag cgc aag aag tcc ttc ctg ctg tgc atc ggc tgg ctg gcg      288 
Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                 85                  90                  95 

ctc acc gac ctg gtc ggg cag ctt ctc acc acc ccg gtc gtc atc gtc      336 
Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

gtg tac ctg tcc aag cag cgt tgg gag cac atc gac ccg tcg ggg cgg      384 
Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

ctc tgc acc ttt ttc ggg ctg acc atg act gtt ttc ggg ctc tcc tcg      432 
Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

ttg ttc atc gcc agc gcc atg gcc gtc gag cgg gcg ctg gcc atc agg      480 
Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

gcg ccg cac tgg tat gcg agc cac atg aag acg cgt gcc acc cgc gct      528 
Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

gtg ctg ctc ggc gtg tgg ctg gcc gtg ctc gcc ttc gcc ctg ctg ccg      576 
Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

gtg ctg ggc gtg ggc cag tac acc gtc cag tgg ccc ggg acg tgg tgc      624 
Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

ttc atc agc acc ggg cga ggg ggc aac ggg act agc tct tcg cat aac      672 
Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

tgg ggc aac ctt ttc ttc gcc tct gcc ttt gcc ttc ctg ggg ctc ttg      720 
Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

gcg ctg aca gtc acc ttt tcc tgc aac ctg gcc acc att aag gcc ctg      768 
Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

gtg tcc cgc tgc cgg gcc aag gcc acg gca tct cag tcc agt gcc cag      816 
Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

tgg ggc cgc atc acg acc gag acg gcc att cag ctt atg ggg atc atg      864 
Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

tgc gtg ctg tcg gtc tgc tgg tct ccg ctc ctg ata atg atg ttg aaa      912 
Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

atg atc ttc aat cag aca tca gtt gag cac tgc aag aca cac acg gag      960 
Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

aag cag aaa gaa tgc aac ttc ttc tta ata gct gtt cgc ctg gct tca     1008 
Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

ctg aac cag atc ttg gat cct tgg gtt tac ctg ctg tta aga aag atc     1056 
Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

ctt ctt cga aag ttt tgc cag atg aga aaa aga aga ctc aga gag caa     1104 
Leu Leu Arg Lys Phe Cys Gln Met Arg Lys Arg Arg Leu Arg Glu Gln 
        355                 360                 365 

tta atc tgc agt ttg cga act ctc aga tac aga ggg caa ctg cac att     1152 
Leu Ile Cys Ser Leu Arg Thr Leu Arg Tyr Arg Gly Gln Leu His Ile 
    370                 375                 380 

gtg ggc aag tac aaa cct atc gtg tgc tga                             1182 
Val Gly Lys Tyr Lys Pro Ile Val Cys 
385                 390 

 
           
             28  
             393  
             PRT  
             Homo sapiens  
           
            28 

Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                  10                  15 

Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
            20                  25                  30 

Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
        35                  40                  45 

Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
    50                  55                  60 

Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
65                  70                  75                  80 

Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                85                  90                  95 

Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

Leu Leu Arg Lys Phe Cys Gln Met Arg Lys Arg Arg Leu Arg Glu Gln 
        355                 360                 365 

Leu Ile Cys Ser Leu Arg Thr Leu Arg Tyr Arg Gly Gln Leu His Ile 
    370                 375                 380 

Val Gly Lys Tyr Lys Pro Ile Val Cys 
385                 390 

 
           
             29  
             1125  
             DNA  
             Homo sapiens  
             
               CDS  
               (1)...(1122)  
               cDNA  
             
           
            29 

atg aag gag acc cgg ggc tac gga ggg gat gcc ccc ttc tgc acc cgc       48 
Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                   10                  15 

ctc aac cac tcc tac aca ggc atg tgg gcg ccc gag cgt tcc gcc gag       96 
Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
             20                  25                  30 

gcg cgg ggc aac ctc acg cgc cct cca ggg tct ggc gag gat tgc gga      144 
Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
         35                  40                  45 

tcg gtg tcc gtg gcc ttc ccg atc acc atg ctg ctc act ggt ttc gtg      192 
Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
     50                  55                  60 

ggc aac gca ctg gcc atg ctg ctc gtg tcg cgc agc tac cgg cgc cgg      240 
Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
 65                  70                  75                  80 

gag agc aag cgc aag aag tcc ttc ctg ctg tgc atc ggc tgg ctg gcg      288 
Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                 85                  90                  95 

ctc acc gac ctg gtc ggg cag ctt ctc acc acc ccg gtc gtc atc gtc      336 
Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

gtg tac ctg tcc aag cag cgt tgg gag cac atc gac ccg tcg ggg cgg      384 
Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

ctc tgc acc ttt ttc ggg ctg acc atg act gtt ttc ggg ctc tcc tcg      432 
Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

ttg ttc atc gcc agc gcc atg gcc gtc gag cgg gcg ctg gcc atc agg      480 
Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

gcg ccg cac tgg tat gcg agc cac atg aag acg cgt gcc acc cgc gct      528 
Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

gtg ctg ctc ggc gtg tgg ctg gcc gtg ctc gcc ttc gcc ctg ctg ccg      576 
Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

gtg ctg ggc gtg ggc cag tac acc gtc cag tgg ccc ggg acg tgg tgc      624 
Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

ttc atc agc acc ggg cga ggg ggc aac ggg act agc tct tcg cat aac      672 
Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

tgg ggc aac ctt ttc ttc gcc tct gcc ttt gcc ttc ctg ggg ctc ttg      720 
Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

gcg ctg aca gtc acc ttt tcc tgc aac ctg gcc acc att aag gcc ctg      768 
Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

gtg tcc cgc tgc cgg gcc aag gcc acg gca tct cag tcc agt gcc cag      816 
Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

tgg ggc cgc atc acg acc gag acg gcc att cag ctt atg ggg atc atg      864 
Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

tgc gtg ctg tcg gtc tgc tgg tct ccg ctc ctg ata atg atg ttg aaa      912 
Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

atg atc ttc aat cag aca tca gtt gag cac tgc aag aca cac acg gag      960 
Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

aag cag aaa gaa tgc aac ttc ttc tta ata gct gtt cgc ctg gct tca     1008 
Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

ctg aac cag atc ttg gat cct tgg gtt tac ctg ctg tta aga aag atc     1056 
Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

ctt ctt cga aag ttt tgc cag atg aga aaa aga aga ctc aga gag caa     1104 
Leu Leu Arg Lys Phe Cys Gln Met Arg Lys Arg Arg Leu Arg Glu Gln 
        355                 360                 365 

gag gaa ttt tgg gga aat taa                                         1125 
Glu Glu Phe Trp Gly Asn 
    370 

 
           
             30  
             374  
             PRT  
             Homo sapiens  
           
            30 

Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                  10                  15 

Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
            20                  25                  30 

Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
        35                  40                  45 

Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
    50                  55                  60 

Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
65                  70                  75                  80 

Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                85                  90                  95 

Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

Leu Leu Arg Lys Phe Cys Gln Met Arg Lys Arg Arg Leu Arg Glu Gln 
        355                 360                 365 

Glu Glu Phe Trp Gly Asn 
    370 

 
           
             31  
             1098  
             DNA  
             Homo sapiens  
             
               CDS  
               (1)...(1095)  
               cDNA  
             
           
            31 

atg aag gag acc cgg ggc tac gga ggg gat gcc ccc ttc tgc acc cgc       48 
Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                   10                  15 

ctc aac cac tcc tac aca ggc atg tgg gcg ccc gag cgt tcc gcc gag       96 
Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
             20                  25                  30 

gcg cgg ggc aac ctc acg cgc cct cca ggg tct ggc gag gat tgc gga      144 
Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
         35                  40                  45 

tcg gtg tcc gtg gcc ttc ccg atc acc atg ctg ctc act ggt ttc gtg      192 
Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
     50                  55                  60 

ggc aac gca ctg gcc atg ctg ctc gtg tcg cgc agc tac cgg cgc cgg      240 
Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
 65                  70                  75                  80 

gag agc aag cgc aag aag tcc ttc ctg ctg tgc atc ggc tgg ctg gcg      288 
Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                 85                  90                  95 

ctc acc gac ctg gtc ggg cag ctt ctc acc acc ccg gtc gtc atc gtc      336 
Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

gtg tac ctg tcc aag cag cgt tgg gag cac atc gac ccg tcg ggg cgg      384 
Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

ctc tgc acc ttt ttc ggg ctg acc atg act gtt ttc ggg ctc tcc tcg      432 
Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

ttg ttc atc gcc agc gcc atg gcc gtc gag cgg gcg ctg gcc atc agg      480 
Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

gcg ccg cac tgg tat gcg agc cac atg aag acg cgt gcc acc cgc gct      528 
Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

gtg ctg ctc ggc gtg tgg ctg gcc gtg ctc gcc ttc gcc ctg ctg ccg      576 
Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

gtg ctg ggc gtg ggc cag tac acc gtc cag tgg ccc ggg acg tgg tgc      624 
Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

ttc atc agc acc ggg cga ggg ggc aac ggg act agc tct tcg cat aac      672 
Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

tgg ggc aac ctt ttc ttc gcc tct gcc ttt gcc ttc ctg ggg ctc ttg      720 
Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

gcg ctg aca gtc acc ttt tcc tgc aac ctg gcc acc att aag gcc ctg      768 
Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

gtg tcc cgc tgc cgg gcc aag gcc acg gca tct cag tcc agt gcc cag      816 
Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

tgg ggc cgc atc acg acc gag acg gcc att cag ctt atg ggg atc atg      864 
Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

tgc gtg ctg tcg gtc tgc tgg tct ccg ctc ctg ata atg atg ttg aaa      912 
Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

atg atc ttc aat cag aca tca gtt gag cac tgc aag aca cac acg gag      960 
Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

aag cag aaa gaa tgc aac ttc ttc tta ata gct gtt cgc ctg gct tca     1008 
Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

ctg aac cag atc ttg gat cct tgg gtt tac ctg ctg tta aga aag atc     1056 
Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

ctt ctt cga aag ttt tgc cag gag gaa ttt tgg gga aat taa             1098 
Leu Leu Arg Lys Phe Cys Gln Glu Glu Phe Trp Gly Asn 
        355                 360                 365 

 
           
             32  
             365  
             PRT  
             Homo sapiens  
           
            32 

Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                  10                  15 

Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
            20                  25                  30 

Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
        35                  40                  45 

Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
    50                  55                  60 

Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
65                  70                  75                  80 

Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                85                  90                  95 

Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

Leu Leu Arg Lys Phe Cys Gln Glu Glu Phe Trp Gly Asn 
        355                 360                 365 

 
           
             33  
             1212  
             DNA  
             Homo sapiens  
             
               CDS  
               (1)...(1206)  
               cDNA  
             
           
            33 

atg aag gag acc cgg ggc tac gga ggg gat gcc ccc ttc tgc acc cgc       48 
Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                   10                  15 

ctc aac cac tcc tac aca ggc atg tgg gcg ccc gag cgt tcc gcc gag       96 
Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
             20                  25                  30 

gcg cgg ggc aac ctc acg cgc cct cca ggg tct ggc gag gat tgc gga      144 
Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
         35                  40                  45 

tcg gtg tcc gtg gcc ttc ccg atc acc atg ctg ctc act ggt ttc gtg      192 
Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
     50                  55                  60 

ggc aac gca ctg gcc atg ctg ctc gtg tcg cgc agc tac cgg cgc cgg      240 
Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
 65                  70                  75                  80 

gag agc aag cgc aag aag tcc ttc ctg ctg tgc atc ggc tgg ctg gcg      288 
Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                 85                  90                  95 

ctc acc gac ctg gtc ggg cag ctt ctc acc acc ccg gtc gtc atc gtc      336 
Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

gtg tac ctg tcc aag cag cgt tgg gag cac atc gac ccg tcg ggg cgg      384 
Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

ctc tgc acc ttt ttc ggg ctg acc atg act gtt ttc ggg ctc tcc tcg      432 
Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

ttg ttc atc gcc agc gcc atg gcc gtc gag cgg gcg ctg gcc atc agg      480 
Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

gcg ccg cac tgg tat gcg agc cac atg aag acg cgt gcc acc cgc gct      528 
Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

gtg ctg ctc ggc gtg tgg ctg gcc gtg ctc gcc ttc gcc ctg ctg ccg      576 
Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

gtg ctg ggc gtg ggc cag tac acc gtc cag tgg ccc ggg acg tgg tgc      624 
Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

ttc atc agc acc ggg cga ggg ggc aac ggg act agc tct tcg cat aac      672 
Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

tgg ggc aac ctt ttc ttc gcc tct gcc ttt gcc ttc ctg ggg ctc ttg      720 
Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

gcg ctg aca gtc acc ttt tcc tgc aac ctg gcc acc att aag gcc ctg      768 
Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

gtg tcc cgc tgc cgg gcc aag gcc acg gca tct cag tcc agt gcc cag      816 
Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

tgg ggc cgc atc acg acc gag acg gcc att cag ctt atg ggg atc atg      864 
Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

tgc gtg ctg tcg gtc tgc tgg tct ccg ctc ctg ata atg atg ttg aaa      912 
Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

atg atc ttc aat cag aca tca gtt gag cac tgc aag aca cac acg gag      960 
Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

aag cag aaa gaa tgc aac ttc ttc tta ata gct gtt cgc ctg gct tca     1008 
Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

ctg aac cag atc ttg gat cct tgg gtt tac ctg ctg tta aga aag atc     1056 
Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

ctt ctt cga aag ttt tgc cag atg aga aaa aga aga ctc aga gag caa     1104 
Leu Leu Arg Lys Phe Cys Gln Met Arg Lys Arg Arg Leu Arg Glu Gln 
        355                 360                 365 

gag atg ggg cct gat gga agg tgt ttt tgt cat gca tgg agg cag gtc     1152 
Glu Met Gly Pro Asp Gly Arg Cys Phe Cys His Ala Trp Arg Gln Val 
    370                 375                 380 

ccc agg act tgg tgc agt tct cat gat aga gaa ccc tgc agt gtc cag     1200 
Pro Arg Thr Trp Cys Ser Ser His Asp Arg Glu Pro Cys Ser Val Gln 
385                 390                 395                 400 

cta agc tgatga                                                      1212 
Leu Ser 

 
           
             34  
             402  
             PRT  
             Homo sapiens  
           
            34 

Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                  10                  15 

Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
            20                  25                  30 

Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
        35                  40                  45 

Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
    50                  55                  60 

Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
65                  70                  75                  80 

Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                85                  90                  95 

Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

Leu Leu Arg Lys Phe Cys Gln Met Arg Lys Arg Arg Leu Arg Glu Gln 
        355                 360                 365 

Glu Met Gly Pro Asp Gly Arg Cys Phe Cys His Ala Trp Arg Gln Val 
    370                 375                 380 

Pro Arg Thr Trp Cys Ser Ser His Asp Arg Glu Pro Cys Ser Val Gln 
385                 390                 395                 400 

Leu Ser 

 
           
             35  
             1185  
             DNA  
             Homo sapiens  
             
               CDS  
               (1)...(1179)  
               cDNA  
             
           
            35 

atg aag gag acc cgg ggc tac gga ggg gat gcc ccc ttc tgc acc cgc       48 
Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                   10                  15 

ctc aac cac tcc tac aca ggc atg tgg gcg ccc gag cgt tcc gcc gag       96 
Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
             20                  25                  30 

gcg cgg ggc aac ctc acg cgc cct cca ggg tct ggc gag gat tgc gga      144 
Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
         35                  40                  45 

tcg gtg tcc gtg gcc ttc ccg atc acc atg ctg ctc act ggt ttc gtg      192 
Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
     50                  55                  60 

ggc aac gca ctg gcc atg ctg ctc gtg tcg cgc agc tac cgg cgc cgg      240 
Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
 65                  70                  75                  80 

gag agc aag cgc aag aag tcc ttc ctg ctg tgc atc ggc tgg ctg gcg      288 
Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                 85                  90                  95 

ctc acc gac ctg gtc ggg cag ctt ctc acc acc ccg gtc gtc atc gtc      336 
Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

gtg tac ctg tcc aag cag cgt tgg gag cac atc gac ccg tcg ggg cgg      384 
Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

ctc tgc acc ttt ttc ggg ctg acc atg act gtt ttc ggg ctc tcc tcg      432 
Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

ttg ttc atc gcc agc gcc atg gcc gtc gag cgg gcg ctg gcc atc agg      480 
Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

gcg ccg cac tgg tat gcg agc cac atg aag acg cgt gcc acc cgc gct      528 
Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

gtg ctg ctc ggc gtg tgg ctg gcc gtg ctc gcc ttc gcc ctg ctg ccg      576 
Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

gtg ctg ggc gtg ggc cag tac acc gtc cag tgg ccc ggg acg tgg tgc      624 
Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

ttc atc agc acc ggg cga ggg ggc aac ggg act agc tct tcg cat aac      672 
Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

tgg ggc aac ctt ttc ttc gcc tct gcc ttt gcc ttc ctg ggg ctc ttg      720 
Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

gcg ctg aca gtc acc ttt tcc tgc aac ctg gcc acc att aag gcc ctg      768 
Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

gtg tcc cgc tgc cgg gcc aag gcc acg gca tct cag tcc agt gcc cag      816 
Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

tgg ggc cgc atc acg acc gag acg gcc att cag ctt atg ggg atc atg      864 
Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

tgc gtg ctg tcg gtc tgc tgg tct ccg ctc ctg ata atg atg ttg aaa      912 
Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

atg atc ttc aat cag aca tca gtt gag cac tgc aag aca cac acg gag      960 
Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

aag cag aaa gaa tgc aac ttc ttc tta ata gct gtt cgc ctg gct tca     1008 
Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

ctg aac cag atc ttg gat cct tgg gtt tac ctg ctg tta aga aag atc     1056 
Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

ctt ctt cga aag ttt tgc cag gag atg ggg cct gat gga agg tgt ttt     1104 
Leu Leu Arg Lys Phe Cys Gln Glu Met Gly Pro Asp Gly Arg Cys Phe 
        355                 360                 365 

tgt cat gca tgg agg cag gtc ccc agg act tgg tgc agt tct cat gat     1152 
Cys His Ala Trp Arg Gln Val Pro Arg Thr Trp Cys Ser Ser His Asp 
    370                 375                 380 

aga gaa ccc tgc agt gtc cag cta agc tgatga                          1185 
Arg Glu Pro Cys Ser Val Gln Leu Ser 
385                 390 

 
           
             36  
             393  
             PRT  
             Homo sapiens  
           
            36 

Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
 1               5                  10                  15 

Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
            20                  25                  30 

Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
        35                  40                  45 

Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
    50                  55                  60 

Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
65                  70                  75                  80 

Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                85                  90                  95 

Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110 

Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125 

Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140 

Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 

Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175 

Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190 

Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205 

Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220 

Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 

Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255 

Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270 

Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285 

Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300 

Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 

Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335 

Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350 

Leu Leu Arg Lys Phe Cys Gln Glu Met Gly Pro Asp Gly Arg Cys Phe 
        355                 360                 365 

Cys His Ala Trp Arg Gln Val Pro Arg Thr Trp Cys Ser Ser His Asp 
    370                 375                 380 

Arg Glu Pro Cys Ser Val Gln Leu Ser 
385                 390