Patent Publication Number: US-2006003323-A1

Title: Therapeutic polypeptides, nucleic acids encoding same, and methods of use

Description:
RELATED APPLICATIONS  
      This application is a continuation-in-part of U.S. Ser. No. 09/789,390, filed Feb. 23, 2001, which claims priority to U.S. Ser. No. 60/185,967, filed Mar. 1, 2000; U.S. Ser. No. 09/823,187, filed Mar. 29, 2001, which claims priority to U.S. Ser. No. 60/195,792, filed Mar. 10, 2000; U.S. Ser. No. 09/839,446, filed Mar. 19, 2001, which claims priority to U.S. Ser. No. 60/199,476, filed Mar. 25, 2000; and U.S. Ser. No. 60/199,476, filed Apr. 25, 20001; U.S. Ser. No. 09/863,776, filed May 23, 2001, which claims priority to U.S. Ser. No. 60/208,263, filed May 31, 2000; U.S. Ser. No. 09/939,398, filed Aug. 24, 2001, which claims priority to U.S. Ser. No. 60/227,800, filed Aug. 25, 2000; U.S. Ser. No. 09/964,956, filed Sep. 26, 2001, which claims priority to U.S. Ser. No. 60/236,135, filed Sep. 28, 2000; U.S. Ser. No. 10/015,115, filed Nov. 13, 2001, which claims priority to U.S. Ser. No. 60/248,153, filed Nov. 13, 2000; U.S. Ser. No. 10/028,248, filed Dec. 19, 2001, which claims priority to U.S. Ser. No. 60/285,189, filed Apr. 20, 2001; U.S. Ser. No. 10/032,189, filed Dec. 21, 2001, which claims priority to U.S. Ser. No. 60/258,171, filed Dec. 22, 2000; and U.S. Ser. No. 60/257,495, filed Dec. 21, 2000; U.S. Ser. No. 10/055,877, filed Jan. 22, 2002, which claims priority to U.S. Ser. No. 60/296,960, filed Jun. 8, 2001 and U.S. Ser. No. 60/335,669, filed Oct. 31, 2001; U.S. Ser. No. 10/072,012, filed Jan. 31, 2002, which claims priority to U.S. Ser. No. 60/265,412, filed Jan. 31, 2001; U.S. Ser. No. 10/080,334, filed Feb. 21, 2002, which claims priority to U.S. Ser. No. 60/270,220, filed Feb. 21, 2001; U.S. Ser. No. 10/093,463, filed Mar. 8, 2002, which claims priority to U.S. Ser. No. 60/277,311, filed Mar. 20, 2001; U.S. Ser. No. 10/114,153, filed Apr. 2, 2002, which claims priority to U.S. Ser. No. 60/283,678, filed Apr. 13, 2001; and U.S. Ser. No. 60/286,292, filed Apr. 25, 2001; U.S. Ser. No. 10/114,270, filed Apr. 2, 2002, which claims priority to U.S. Ser. No. 60/281,136, filed Apr. 3, 2001; U.S. Ser. No. 10/138,588, filed Apr. 1, 2002 which claims priority to U.S. Ser. No. 60/288,900, filed May 4, 2001; U.S. Ser. No. 09/783,429, filed Feb. 14, 2001; U.S. Ser. No. 09/800,198, filed Mar. 5, 2001; U.S. Ser. No. 10/023,634, filed Dec. 17, 2001; U.S. Ser. No. 10/038,854, filed Dec. 31, 2001; U.S. Ser. No. 10/051,874, filed Jan. 16, 2002; and U.S. Ser. No. 10/072,013, filed Feb. 8, 2002; and claims the benefit of U.S. Ser. No. 60/386,376, filed Jun. 6, 2002; U.S. Ser. No. 60/385,784, filed Jun. 4, 2002;U.S. Ser. No. 60/386,453, filed Jun. 6, 2002; U.S. Ser. No. 60/402,389, filed Aug. 9, 2002; U.S. Ser. No. 60/412,528, filed Sep. 20, 2002; U.S. Ser. No. 60/387,016, filed Jun. 6, 2002; U.S. Ser. No. 60/386,796, filed Jun. 7, 2002; U.S. Ser. No. 60/386,971, filed Jun. 7, 2002; U.S. Ser. No. 60/386,041, filed Jun. 5, 2002; U.S. Ser. No. 60/387,610, filed Jun. 11, 2002; U.S. Ser. No. 60/386,047, filed Jun. 5, 2002; U.S. Ser. No. 60/387,400, filed Jun. 10, 2002; U.S. Ser. No. 60/402,156, filed Aug. 9, 2002; U.S. Ser. No. 60/386,816, filed Jun. 7, 2002; U.S. Ser. No. 60/402,256, filed Aug. 9, 2002; U.S. Ser. No. 60/389,144, filed Jun. 14, 2002; U.S. Ser. No. 60/386,942, filed Jun. 7, 2002; U.S. Ser. No. 60/387,262, filed Jun. 7, 2002; U.S. Ser. No. 60/389,120, filed Jun. 14, 2002; U.S. Ser. No. 60/421,156, filed Oct. 28, 2002; U.S. Ser. No. 60/423,130, filed Nov. 1, 2002; U.S. Ser. No. 60/425,453, filed Nov. 12, 2002; U.S. Ser. No. 60/386,931, filed Jun. 7, 2002; U.S. Ser. No. 60/403,459, filed Aug. 13, 2002; U.S. Ser. No. 60/387,535, filed Jun. 10, 2002; U.S. Ser. No. 60/403,448, filed Aug. 13, 2002; U.S. Ser. No. 60/423,798, filed Nov. 5, 2002; U.S. Ser. No. 60/387,859, filed Jun. 11, 2002; U.S. Ser. No. 60/402,821, filed Aug. 12, 2002; U.S. Ser. No. 60/417,186, filed Oct. 9, 2002; U.S. Ser. No. 10/015,115, filed Nov. 13, 2001; U.S. Ser. No. 60/387,702, filed Jun. 11, 2002; U.S. Ser. No. 60/387,634, filed Jun. 11, 2002; U. S.S. N. 60/387,934, filed Jun. 12,2002; U.S. Ser. No. 60/387,696, filed Jun. 11, 2002; U.S. Ser. No. 60/390,006, filed Jun. 19, 2002; U.S. Ser. No. 60/387,668, filed Jun. 11, 2002; U.S. Ser. No. 60/402,786, filed Aug. 12, 2002; U.S. Ser. No. 60/410,084, filed Sep. 1 2, 2002 ; U.S. Ser. No. 60/420,639, filed Oct. 23, 2002; U.S. Ser. No. 60/386,864, filed Jun. 6, 2002; U.S. Ser. No. 60/401,628, filed Aug. 6, 2002; U.S. Ser. No. 60/406,182, filed Aug. 26, 2002; U.S. Ser. No. 60/387,836, filed Jun. 11, 2002; U.S. Ser. No. 60/389,729, filed Jun. 17, 2002; U.S. Ser. No. 60/388,022, filed Jun. 12, 2002; U.S. Ser. No. 60/402,816, filed Aug. 12, 2002; U.S. Ser. No. 60/412,731, filed Sep. 23, 2002; U.S. Ser. No. 60/414,954, filed Sep. 30, 2002; U.S. Ser. No. 60 /388,096, filed Jun. 12, 2002; U.S. Ser. No. 60/414,840, filed Sep. 30, 2002; U.S. Ser. No. 60/417,406, filed Oct. 9, 2002; U.S. Ser. No. 60/389,123, filed Jun. 13, 2002; U.S. Ser. No. 60/402,832, filed Aug. 12, 2002; U.S. Ser. No. 60/403,532, filed Aug. 13, 2002; U.S. Ser. No. 60/414,839, filed Sep. 30, 2002; U.S. Ser. No. 60/387,625, filed Jun. 11, 2002; U.S. Ser. No. 60/390,209, filed Jun. 19, 2002; U.S. Ser. No. 60/403,531, filed Aug. 13, 2002; U.S. Ser. No. 60/387,933, filed Jun. 12, 2002; U.S. Ser. No. 60/406,355, filed Aug. 26, 2002; U.S. Ser. No. 10/094,886, filed Mar. 7, 2002; U.S. Ser. No. 60/389,118, filed Jun. 14, 2002; U.S. Ser. No. 60/406,317, filed Aug. 13, 2002; U.S. Ser. No. 60/403,563, filed Aug. 13, 2002; U.S. Ser. No. 60/389,884, filed Jun. 18, 2002; U.S. Ser. No. 60/406,240, filed Aug. 27, 2002; U.S. Ser. No. 60/389,146, filed Jun. 14, 2002; U.S. Ser. No. 60/387,960, filed Jun. 12, 2002; U.S. Ser. No. 60/403,617, filed Aug. 15, 2002; U.S. Ser. No. 60/348,693, filed Jan. 14, 2002; U.S. Ser. No. 60/390,763, filed Jun. 21, 2002; U.S. Ser. No. 60/385,120, filed Jun. 3, 2002; U.S. Ser. No. 60/414,801, filed Sep. 30, 2002; U.S. Ser. No. 60/422,690, filed Oct. 31, 2002; U.S. Ser. No. 60/389,742, filed Jun. 17, 2002; U.S. Ser. No. 60/396,706, filed Jul. 17, 2002. 
    
    
     FIELD OF THE INVENTION  
      The present invention relates to novel polypeptides, and the nucleic acids encoding them, having properties related to stimulation of biochemical or physiological responses in a cell, a tissue, an organ or an organism. More particularly, the novel polypeptides are gene products of novel genes, or are specified biologically active fragments or derivatives thereof. Methods of use encompass diagnostic and prognostic assay procedures as well as methods of treating diverse pathological conditions.  
     BACKGROUND OF THE INVENTION  
      Eukaryotic cells are characterized by biochemical and physiological processes which under normal conditions are exquisitely balanced to achieve the preservation and propagation of the cells. When such cells are components of multicellular organisms such as vertebrates, or more particularly organisms such as mammals, the regulation of the biochemical and physiological processes involves intricate signaling pathways. Frequently, such signaling pathways involve extracellular signaling proteins, cellular receptors that bind the signaling proteins, and signal transducing components located within the cells.  
      Signaling proteins may be classified as endocrine effectors, paracrine effectors or autocrine effectors. Endocrine effectors are signaling molecules secreted by a given organ into the circulatory system, which are then transported to a distant target organ or tissue. The target cells include the receptors for the endocrine effector, and when the endocrine effector binds, a signaling cascade is induced. Paracrine effectors involve secreting cells and receptor cells in close proximity to each other, for example two different classes of cells in the same tissue or organ. One class of cells secretes the paracrine effector, which then reaches the second class of cells, for example by diffusion through the extracellular fluid. The second class of cells contains the receptors for the paracrine effector; binding of the effector results in induction of the signaling cascade that elicits the corresponding biochemical or physiological effect. Autocrine effectors are highly analogous to paracrine effectors, except that the same cell type that secretes the autocrine effector also contains the receptor. Thus the autocrine effector binds to receptors on the same cell, or on identical neighboring cells. The binding process then elicits the characteristic biochemical or physiological effect.  
      Signaling processes may elicit a variety of effects on cells and tissues including by way of nonlimiting example induction of cell or tissue proliferation, suppression of growth or proliferation, induction of differentiation or maturation of a cell or tissue, and suppression of differentiation or maturation of a cell or tissue.  
      Many pathological conditions involve dysregulation of expression of important effector proteins. In certain classes of pathologies the dysregulation is manifested as diminished or suppressed level of synthesis and secretion of protein effectors. In other classes of pathologies the dysregulation is manifested as increased or up-regulated level of synthesis and secretion of protein effectors. In a clinical setting a subject may be suspected of suffering from a condition brought on by altered or mis-regulated levels of a protein effector of interest. Therefore there is a need to assay for the level of the protein effector of interest in a biological sample from such a subject, and to compare the level with that characteristic of a nonpathological condition. There also is a need to provide the protein effector as a product of manufacture. Administration of the effector to a subject in need thereof is useful in treatment of the pathological condition. Accordingly, there is a need for a method of treatment of a pathological condition brought on by a diminished or suppressed levels of the protein effector of interest. In addition, there is a need for a method of treatment of a pathological condition brought on by a increased or up-regulated levels of the protein effector of interest.  
      Antibodies are multichain proteins that bind specifically to a given antigen, and bind poorly, or not at all, to substances deemed not to be cognate antigens. Antibodies are comprised of two short chains termed light chains and two long chains termed heavy chains. These chains are constituted of immunoglobulin domains, of which generally there are two classes: one variable domain per chain, one constant domain in light chains, and three or more constant domains in heavy chains. The antigen-specific portion of the immunoglobulin molecules resides in the variable domains; the variable domains of one light chain and one heavy chain associate with each other to generate the antigen-binding moiety. Antibodies that bind immunospecifically to a cognate or target antigen bind with high affinities. Accordingly, they are useful in assaying specifically for the presence of the antigen in a sample. In addition, they have the potential of inactivating the activity of the antigen.  
      Therefore there is a need to assay for the level of a protein effector of interest in a biological sample from such a subject, and to compare this level with that characteristic of a nonpathological condition. In particular, there is a need for such an assay based on the use of an antibody that binds immunospecifically to the antigen. There further is a need to inhibit the activity of the protein effector in cases where a pathological condition arises from elevated or excessive levels of the effector based on the use of an antibody that binds immunospecifically to the effector. Thus, there is a need for the antibody as a product of manufacture. There further is a need for a method of treatment of a pathological condition brought on by an elevated or excessive level of the protein effector of interest based on administering the antibody to the subject.  
     SUMMARY OF THE INVENTION  
      The invention is based in part upon the discovery of isolated polypeptides including amino acid sequences selected from mature forms of the amino acid sequences selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606. The novel nucleic acids and polypeptides are referred to herein as NOV1a, NOV1b, NOV1c, NOV1d, NOV2a, NOV2b, NOV2c, NOV2d, NOV3a, NOV3b, etc. These nucleic acids and polypeptides, as well as derivatives, homologs, analogs and fragments thereof, will hereinafter be collectively designated as “NOVX” nucleic acid or polypeptide sequences.  
      The invention also is based in part upon variants of a mature form of the amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606, wherein any amino acid in the mature form is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence of the mature form are so changed. In another embodiment, the invention includes the amino acid sequences selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606. In another embodiment, the invention also comprises variants of the amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606 wherein any amino acid specified in the chosen sequence is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence are so changed. The invention also involves fragments of any of the mature forms of the amino acid sequences selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606, or any other amino acid sequence selected from this group. The invention also comprises fragments from these groups in which up to 15% of the residues are changed.  
      In another embodiment, the invention encompasses polypeptides that are naturally occurring allelic variants of the sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606. These allelic variants include amino acid sequences that are the translations of nucleic acid sequences differing by a single nucleotide from nucleic acid sequences selected from the group consisting of SEQ ID NOS: 2n−1, wherein n is an integer between 1 and 606. The variant polypeptide where any amino acid changed in the chosen sequence is changed to provide a conservative substitution.  
      In another embodiment, the invention comprises a pharmaceutical composition involving a polypeptide with an amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606 and a pharmaceutically acceptable carrier. In another embodiment, the invention involves a kit, including, in one or more containers, this pharmaceutical composition.  
      In another embodiment, the invention includes the use of a therapeutic in the manufacture of a medicament for treating a syndrome associated with a human disease, the disease being selected from a pathology associated with a polypeptide with an amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606 wherein said therapeutic is the polypeptide selected from this group.  
      In another embodiment, the invention comprises a method for determining the presence or amount of a polypeptide with an amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606 in a sample, the method involving providing the sample; introducing the sample to an antibody that binds immunospecifically to the polypeptide; and determining the presence or amount of antibody bound to the polypeptide, thereby determining the presence or amount of polypeptide in the sample.  
      In another embodiment, the invention includes a method for determining the presence of or predisposition to a disease associated with altered levels of a polypeptide with an amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606 in a first mammalian subject, the method involving measuring the level of expression of the polypeptide in a sample from the first mammalian subject; and comparing the amount of the polypeptide in this sample to the amount of the polypeptide present in a control sample from a second mammalian subject known not to have, or not to be predisposed to, the disease, wherein an alteration in the expression level of the polypeptide in the first subject as compared to the control sample indicates the presence of or predisposition to the disease.  
      In another embodiment, the invention involves a method of identifying an agent that binds to a polypeptide with an amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606, the method including introducing the polypeptide to the agent; and determining whether the agent binds to the polypeptide. The agent could be a cellular receptor or a downstream effector.  
      In another embodiment, the invention involves a method for identifying a potential therapeutic agent for use in treatment of a pathology, wherein the pathology is related to aberrant expression or aberrant physiological interactions of a polypeptide with an amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606, the method including providing a cell expressing the polypeptide of the invention and having a property or function ascribable to the polypeptide; contacting the cell with a composition comprising a candidate substance; and determining whether the substance alters the property or function ascribable to the polypeptide; whereby, if an alteration observed in the presence of the substance is not observed when the cell is contacted with a composition devoid of the substance, the substance is identified as a potential therapeutic agent.  
      In another embodiment, the invention involves a method forscreening for a modulator of activity or of latency or predisposition to a pathology associated with a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606, the method including administering a test compound to a test animal at increased risk for a pathology associated with the polypeptide of the invention, wherein the test animal recombinantly expresses the polypeptide of the invention; measuring the activity of the polypeptide in the test animal after administering the test compound; and comparing the activity of the protein in the test animal with the activity of the polypeptide in a control animal not administered the polypeptide, wherein a change in the activity of the polypeptide in the test animal relative to the control animal indicates the test compound is a modulator of latency of, or predisposition to,. a pathology associated with the polypeptide of the invention. The recombinant test animal could express a test protein transgene or express the transgene under the control of a promoter at an increased level relative to a wild-type test animal The promoter may or may not b the native gene promoter of the transgene.  
      In another embodiment, the invention involves a method for modulating the activity of a polypeptide with an amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606, the method including introducing a cell sample expressing the polypeptide with a compound that binds to the polypeptide in an amount sufficient to modulate the activity of the polypeptide.  
      In another embodiment, the invention involves a method of treating or preventing a pathology associated with a polypeptide with an amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606, the method including administering the polypeptide to a subject in which such treatment or prevention is desired in an amount sufficient to treat or prevent the pathology in the subject. The subject could be human.  
      In another embodiment, the invention involves a method of treating a pathological state in a mammal, the method including administering to the mammal a polypeptide in an amount that is sufficient to alleviate the. pathological state, wherein the polypeptide is a polypeptide having an amino acid sequence at least 95% identical to a polypeptide having the amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606 or a biologically active fragment thereof.  
      In another embodiment, the invention involves an isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide having an amino acid sequence selected from the group consisting of a mature form of the amino acid sequence given SEQ ID NO:2n, wherein n is an integer between 1 and 606; a variant of a mature form of the amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606 wherein any amino acid in the mature form of the chosen sequence is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence of the mature form are so changed; the amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606; a variant of the amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606, in which any amino acid specified in the chosen sequence is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence are so changed; a nucleic acid fragment encoding at least a portion of a polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606 or any variant of the polypeptide wherein any amino-acid of the chosen sequence is changed to a different amino acid, provided that no more than 10% of the amino acid residues in the sequence are so changed; and the complement of any of the nucleic acid molecules.  
      In another embodiment, the invention comprises an isolated nucleic acid molecule having a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of a mature form of the amino acid sequence given SEQ ID NO:2n, wherein n is an integer between 1 and 606, wherein the nucleic acid molecule comprises the nucleotide sequence of a naturally occurring allelic nucleic acid variant.  
      In another embodiment, the invention involves an isolated nucleic acid, molecule including a nucleic acid sequence encoding a polypeptide having an amino acid sequence selected from the group consisting of a mature form of the amino acid sequence given SEQ ID NO:2n, wherein n is an integer between 1 and 606 that encodes a variant polypeptide, wherein the variant polypeptide has the polypeptide sequence of a naturally occurring polypeptide variant.  
      In another embodiment, the invention comprises an isolated nucleic acid molecule having a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of a mature form of the amino acid sequence given SEQ ID NO:2n, wherein n is an integer between 1 and 606, wherein the nucleic acid molecule differs by a single nucleotide from a nucleic acid sequence selected from the group consisting of SEQ. ID NOS: 2n−1, wherein n is an integer between 1 and 606.  
      In another embodiment, the invention includes an isolated nucleic acid molecule having a nucleic acid sequence encoding a polypeptide including an amino acid sequence selected from the group consisting of a mature form of the amino acid sequence given SEQ ID NO:2n, wherein n is an integer between 1 and 606, wherein the nucleic acid molecule comprises a nucleotide sequence selected from the group consisting of the nucleotide sequence selected from the group consisting of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606; a nucleotide sequence wherein one or more nucleotides in the nucleotide sequence selected from the group consisting of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606 is changed from that selected from the group consisting of the chosen sequence to a different nucleotide provided that no more than 15% of the nucleotides are so changed; a nucleic acid fragment of the sequence selected from the group consisting of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606; and a nucleic acid fragment wherein one or more nucleotides in the nucleotide sequence selected from the group consisting of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606 is changed from that selected from the group consisting of the chosen sequence to a different nucleotide provided that no more than 15% of the nucleotides are so changed.  
      In another embodiment, the invention includes an isolated nucleic acid molecule having a nucleic acid sequence encoding a polypeptide including an amino acid sequence selected from the group consisting of a mature form of the amino acid sequence given SEQ ID NO:2n, wherein n isan integer between 1 and 606, wherein the nucleic acid molecule hybridizes under stringent conditions to the nucleotide sequence selected from the group consisting of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, or a complement of the nucleotide sequence.  
      In another embodiment, the invention includes an isolated nucleic acid molecule having a nucleic acid sequence encoding. a polypeptide including an amino acid sequence selected from the group consisting of a mature form of the amino acid sequence given SEQ ID NO:2n, wherein n is an integer between 1 and 606, wherein the nucleic acid molecule has a nucleotide sequence in which any nucleotide specified in the coding sequence of the chosen nucleotide sequence is changed from that selected from the group consisting of the chosen sequence to a different nucleotide provided that no more than 15% of the nucleotides in the chosen coding sequence are so changed, an isolated second polynucleotide that is a complement of the first polynucleotide, or a fragment of any of them.  
      In another embodiment, the invention includes a vector involving the nucleic acid molecule having a nucleic acid sequence encoding a polypeptide including an amino acid sequence selected from the group consisting of a mature form of the amino acid sequence given SEQ ID NO:2n, wherein n is an integer between 1 and 606. This vector can have a promoter operably linked to the nucleic acid molecule. This vector can be located within a cell.  
      In another embodiment, the invention involves a method for determining the presence or amount of a nucleic acid molecule having a nucleic acid sequence encoding a polypeptide including an amino acid sequence selected from the group consisting of a mature form of the amino acid sequence given SEQ ID NO:2n, wherein n is an integer between 1 and 606 in a sample, the method including providing the sample; introducing the sample to a probe that binds to the nucleic acid molecule; and determining the presence or amount of the probe bound to the nucleic acid molecule, thereby determining the presence or amount of the nucleic acid molecule in the sample. The presence or amount of the nucleic acid molecule is used as a marker for cell or tissue type. The cell type can be cancerous.  
      In another embodiment, the invention involves a method for determining the presence of or predisposition for a disease associated with altered levels of a nucleic acid molecule having a nucleic acid sequence encoding a polypeptide including an amino acid sequence selected from the group consisting of a mature form of the amino acid sequence given SEQ ID NO:2n, wherein n is an integer between 1 and 606 in a first mammalian subject, the method including measuring the amount of the nucleic acid in a sample from the first mammalian subject; and comparing the amount of the nucleic acid in the sample of step (a) to the amount of the nucleic acid present in a control sample from a second mammalian subject known not to have or not be predisposed to, the disease; wherein an alteration in the level of the nucleic acid in the first subject as compared to the control sample indicates the presence of or predisposition to the disease.  
      The invention further provides an antibody that binds immunospecifically to a NOVX polypeptide. The NOVX antibody may be monoclonal, humanized, or a fully human antibody. Preferably, the antibody has a dissociation constant for the binding of the NOVX polypeptide to the antibody less than 1×10 −9  M. More preferably, the NOVX antibody neutralizes the activity of the NOVX polypeptide.  
      In a further aspect, the invention provides for the use of a therapeutic in the manufacture of a medicament for treating a syndrome associated with a human disease, associated with a NOVX polypeptide. Preferably the therapeutic is a NOVX antibody.  
      In yet a further aspect, the invention provides a method of treating or preventing a NOVX-associated disorder, a method of treating a pathological state in a mammal, and a method of treating or preventing a pathology associated with a polypeptide by administering a NOVX antibody to a subject in an amount sufficient to treat or prevent the disorder.  
      Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In the case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and are not intended to be limiting.  
      Other features and advantages of the invention will be apparent from the following detailed description and claims.  
    
    
     BRIEF DESCRIPTION OF THE DRAWINGS  
       FIG. 1  is a table illustrating the SAGE library data results illustrating overexpression of LIV-1 in breast carcinoma derived cells.  
       FIG. 2  is is a bar graph showing that antisense knockdown of LIV-1 inhibits breast carcinoma cell line T47D cell growth.  
       FIG. 3  is is a bar graph showing that antisense knockdown of LwV-1 has less inhibitory effect on Ovcar-4 cell growth.  
       FIG. 4  is is a bar graph showing RTQPCR validation of knockdown of LIV-1 expression at mRNA level in T47D breast cancer cell lines. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION  
      The present invention provides novel nucleotides and polypeptides encoded thereby. Included in the invention are the novel nucleic acid sequences, their encoded polypeptides, antibodies, and other related compounds. The sequences are collectively referred to herein as “NOVX nucleic acids” or “NOVX polynucleotides” and the corresponding encoded polypeptides are referred to as “NOVX polypeptides” or “NOVX proteins.” Unless indicated otherwise, “NOVX” is meant to refer to any of the novel sequences disclosed herein. Table A provides a summary of the NOVX nucleic acids and their encoded polypeptides.  
               TABLE A                          Sequences and Corresponding SEQ ID Numbers                                 NOVX   Internal   SEQ ID NO   SEQ ID NO           Assignment   Identification   (nucleic acid)   (amino acid)   Homology                                         NOV1a   CG191083-01   1   2   VON WILLEBRAND factor A- related protein homolog -  Mus musculus         NOV2a   CG191745-01   3   4   Integrin alpha-2 precursor (Platelet                       membrane glycoprotein Ia) (GPIa) (CD49b) -  Homo sapiens         NOV3a   CG50253-01   5   6   Human secreted protein SCEP-39       NOV3b   250095765   7   8   Human secreted protein SCEP-39       NOV3c   250095742   9   10   Human secreted protein SCEP-39       NOV3d   250095779   11   12   Human secreted protein SCEP-39       NOV3e   250095794   13   14   Human secreted protein SCEP-39       NOV3f   250095734   15   16   Human secreted protein SCEP-39       NOV3g   250095811   17   18   Human secreted protein SCEP-39       NOV3h   250095799   19   20   Human secreted protein SCEP-39       NOV3i   SNP13377609   21   22   Human secreted protein SCEP-39       NOV3j   SNP13373929   23   24   Human secreted protein SCEP-39       NOV3k   SNP13380272   25   26   Human secreted protein SCEP-39       NOV3l   SNP13379745   27   28   Human secreted protein SCEP-39       NOV3m   SNP13373930   29   30   Human secreted protein SCEP-39       NOV4a   CG50377-04   31   32   CSMD1 -  Mus musculus         NOV4b   CG50377-01   33   34   CSMD1 -  Mus musculus         NOV4c   CG50377-02   35   36   CSMD1 -  Mus musculus         NOV4d   CG50377-03   37   38   CSMD1 -  Mus musculus         NOV4e   CG50377-05   39   40   CSMD1 -  Mus musculus         NOV4f   CG50377-06   41   42   CSMD1 -  Mus musculus         NOV4g   273095147   43   44   CSMD1 -  Mus musculus         NOV4h   317459653   45   46   CSMD1 -  Mus musculus         NOV4i   317459612   47   48   CSMD1 -  Mus musculus         NOV4j   317286331   49   50   CSMD1 -  Mus musculus         NOV4k   CG50377-07   51   52   CSMD1 -  Mus musculus         NOV4l   CG50377-08   53   54   CSMD1 -  Mus musculus         NOV4m   CG50377-09   55   56   CSMD1 -  Mus musculus         NOV4n   CG50377-10   57   58   CSMD1 -  Mus musculus         NOV4o   CG50377-11   59   60   CSMD1 -  Mus musculus         NOV4p   SNP13382457   61   62   CSMD1 -  Mus musculus         NOV4q   SNP13382458   63   64   CSMD1 -  Mus musculus         NOV5a   CG50389-04   65   66   Interleukin 1 receptor-like 2 precursor (IL-1Rrp2)                       (IL1R-rp2) -  Homo sapiens         NOV5b   CG50389-06   67   68   Interleukin 1 receptor-like 2 precursor (IL-1Rrp2)                       (IL1R-rp2) -  Homo sapiens         NOV5c   257448648   69   70   Interleukin 1 receptor-like 2 precursor (IL-1Rrp2)                       (IL1R-rp2) -  Homo sapiens         NOV5d   CG50389-01   71   72   Interleukin 1 receptor-like 2 precursor (IL-1Rrp2)                       (IL1R-rp2) -  Homo sapiens         NOV5e   CG50389-02   73   74   Interleukin 1 receptor-like 2 precursor (IL-1Rrp2)                       (IL1R-rp2) -  Homo sapiens         NOV5f   CG50389-03   75   76   Interleukin 1 receptor-like 2 precursor (IL-1Rrp2)                       (IL1R-rp2) -  Homo sapiens         NOV5g   CG50389-05   77   78   Interleukin 1 receptor-like 2 precursor (IL-1Rrp2)                       (IL1R-rp2) -  Homo sapiens         NOV5h   SNP13382464   79   80   Interleukin 1 receptor-like 2 precursor (IL-1Rrp2)                       (IL1R-rp2) -  Homo sapiens         NOV6a   CG50391-08   81   82   Human protease-inhibitor like protein       NOV6b   CG50391-09   83   84   Human protease-inhibitor like protein       NOV6c   CG50391-10   85   86   Human protease-inhibitor like protein       NOV6d   CG50391-01   87   88   Human protease-inhibitor like protein       NOV6e   CG50391-02   89   90   Human protease-inhibitor like protein       NOV6f   CG50391-03   91   92   Human protease-inhibitor like protein       NOV6g   CG50391-04   93   94   Human protease-inhibitor like protein       NOV6h   CG50391-05   95   96   Human protease-inhibitor like protein       NOV6i   CG50391-06   97   98   Human protease-inhibitor like protein       NOV6j   CG50391-07   99   100   Human protease-inhibitor like protein       NOV6k   CG50391-11   101   102   Human protease-inhibitor like protein       NOV6l   SNP13376336   103   104   Human protease-inhibitor like protein       NOV6m   SNP13376335   105   106   Human protease-inhibitor like protein       NOV6n   SNP13376334   107   108   Human protease-inhibitor like protein       NOV6o   SNP13376333   109   110   Human protease-inhibitor like protein       NOV6p   SNP13382488   111   112   Human protease-inhibitor like protein       NOV7a   CG50426-17   113   114   Ten-m2 -  Mus musculus         NOV7b   CG50426-21   115   116   Ten-m2 -  Mus musculus         NOV7c   CG50426-15   117   118   Ten-m2 -  Mus musculus         NOV7d   306276924   119   120   Ten-m2 -  Mus musculus         NOV7e   306276936   121   122   Ten-m2 -  Mus musculus         NOV7f   308530526   123   124   Ten-m2 -  Mus musculus         NOV7g   308530589   125   126   Ten-m2 -  Mus musculus         NOV7h   CG50426-01   127   128   Ten-m2 -  Mus musculus         NOV7i   CG50426-02   129   130   Ten-m2 -  Mus musculus         NOV7j   CG50426-03   131   132   Ten-m2 -  Mus musculus         NOV7k   CG50426-04   133   134   Ten-m2 -  Mus musculus         NOV7l   CG50426-05   135   136   Ten-m2 -  Mus musculus         NOV7m   CG50426-06   137   138   Ten-m2 -  Mus musculus         NOV7n   CG50426-07   139   140   Ten-m2 -  Mus musculus         NOV7o   CG50426-08   141   142   Ten-m2 -  Mus musculus         NOV7p   CG50426-09   143   144   Ten-m2 -  Mus musculus         NOV7q   CG50426-10   145   146   Ten-m2 -  Mus musculus         NOV7r   CG50426-11   147   148   Ten-m2 -  Mus musculus         NOV7s   CG50426-12   149   150   Ten-m2 -  Mus musculus         NOV7t   CG50426-13   151   152   Ten-m2 -  Mus musculus         NOV7u   CG50426-14   153   154   Ten-m2 -  Mus musculus         NOV7v   CG50426-16   155   156   Ten-m2 -  Mus musculus         NOV7w   CG50426-18   157   158   Ten-m2 -  Mus musculus         NOV7x   CG50426-19   159   160   Ten-m2 -  Mus musculus         NOV7y   CG50426-20   161   162   Ten-m2 -  Mus musculus         NOV7z   CG50426-22   163   164   Ten-m2 -  Mus musculus         NOV7a   CG50426-23   165   166   Ten-m2 -  Mus musculus         NOV7b   CG50426-24   167   168   Ten-m2 -  Mus musculus         NOV7c   CG50426-25   169   170   Ten-m2 -  Mus musculus         NOV7d   SNP13375665   171   172   Ten-m2 -  Mus musculus         NOV7e   SNP13375213   173   174   Ten-m2 -  Mus musculus         NOV7f   SNP13374985   175   176   Ten-m2 -  Mus musculus         NOV8a   CG50646-04   177   178   Polydom protein precursor -  Mus musculus         NOV8b   237582568   179   180   Polydom protein precursor -  Mus musculus         NOV8c   236589434   181   182   Polydom protein precursor -  Mus musculus         NOV8d   236495259   183   184   Polydom protein precursor -  Mus musculus         NOV8e   236495256   185   186   Polydom protein precursor -  Mus musculus         NOV8f   CG50646-01   187   188   Polydom protein precursor -  Mus musculus         NOV8g   CG50646-02   189   190   Polydom protein precursor -  Mus musculus         NOV8h   CG50646-03   191   192   Polydom protein precursor -  Mus musculus         NOV8i   CG50646-05   193   194   Polydom protein precursor -  Mus musculus         NOV8j   SNP13380898   195   196   Polydom protein precursor -  Mus musculus         NOV8k   SNP13380899   197   198   Polydom protein precursor -  Mus musculus         NOV8l   SNP13374702   199   200   Polydom protein precursor -  Mus musculus         NOV8m   SNP13374257   201   202   Polydom protein precursor -  Mus musculus         NOV8n   SNP13382479   203   204   Polydom protein precursor -  Mus musculus         NOV8o   SNP13382480   205   206   Polydom protein precursor -  Mus musculus         NOV9a   CG50736-09   207   208   CD44-like precursor FELL -  Homo sapiens         NOV9b   197408749   209   210   CD44-like precursor FELL -  Homo sapiens         NOV9c   CG50736-01   211   212   CD44-like precursor FELL -  Homo sapiens         NOV9d   CG50736-02   213   214   CD44-like precursor FELL -  Homo sapiens         NOV9e   CG50736-03   215   216   CD44-like precursor FELL -  Homo sapiens         NOV9f   CG50736-04   217   218   CD44-like precursor FELL -  Homo sapiens         NOV9g   CG50736-05   219   220   CD44-like precursor FELL -  Homo sapiens         NOV9h   CG50736-06   221   222   CD44-like precursor FELL -  Homo sapiens         NOV9i   CG50736-07   223   224   CD44-like precursor FELL -  Homo sapiens         NOV9j   CG50736-08   225   226   CD44-like precursor FELL -  Homo sapiens         NOV9k   CG50736-10   227   228   CD44-like precursor FELL -  Homo sapiens         NOV9l   CG50736-11   229   230   CD44-like precursor FELL -  Homo sapiens         NOV9m   CG50736-12   231   232   CD44-like precursor FELL -  Homo sapiens         NOV9n   CG50736-13   233   234   CD44-like precursor FELL -  Homo sapiens         NOV9o   CG50736-14   235   236   CD44-like precursor FELL -  Homo sapiens         NOV9p   CG50736-15   237   238   CD44-like precursor FELL -  Homo sapiens         NOV9q   CG50736-16   239   240   CD44-like precursor FELL -  Homo sapiens         NOV9r   CG50736-17   241   242   CD44-like precursor FELL -  Homo sapiens         NOV9s   CG50736-18   243   244   CD44-like precursor FELL -  Homo sapiens         NOV9t   CG50736-19   245   246   CD44-like precursor FELL -  Homo sapiens         NOV9u   CG50736-20   247   248   CD44-like precursor FELL -  Homo sapiens         NOV9v   CG50736-21   249   250   CD44-like precursor FELL -  Homo sapiens         NOV9w   CG50736-22   251   252   CD44-like precursor FELL -  Homo sapiens         NOV9x   CG50736-23   253   254   CD44-like precursor FELL -  Homo sapiens         NOV9y   CG50736-24   255   256   CD44-like precursor FELL -  Homo sapiens         NOV10a   CG50925-01   257   258   Tumor endothelial marker 5 precursor -  Homo sapiens         NOV10b   CG50925-08   259   260   Tumor endothelial marker 5 precursor -  Homo sapiens         NOV10c   226990087   261   262   Tumor endothelial marker 5 precursor -  Homo sapiens         NOV10d   320054488   263   264   Tumor endothelial marker 5 precursor -  Homo sapiens         NOV10e   CG50925-02   265   266   Tumor endothelial marker 5 precursor -  Homo sapiens         NOV10f   248208844   267   268   Tumor endothelial marker 5 precursor -  Homo sapiens         NOV10g   CG50925-03   269   270   Tumor endothelial marker 5 precursor -  Homo sapiens         NOV10h   CG50925-04   271   272   Tumor endothelial marker 5 precursor -  Homo sapiens         NOV10i   CG50925-05   273   274   Tumor endothelial marker 5 precursor -  Homo sapiens         NOV10j   CG50925-06   275   276   Tumor endothelial marker 5 precursor -  Homo sapiens         NOV10k   CG50925-07   277   278   Tumor endothelial marker 5 precursor -  Homo sapiens         NOV10l   SNP13380040   279   280   Tumor endothelial marker 5 precursor -  Homo sapiens         NOV11a   CG51027-06   281   282   Human immunoglobulin superfamily protein IGSFP-9       NOV11b   278391205   283   284   Human immunoglobulin superfamily protein IGSFP-9       NOV11c   278391050   285   286   Human immunoglobulin superfamily protein IGSFP-9       NOV11d   277582210   287   288   Human immunoglobulin superfamily protein IGSFP-9       NOV11e   277582173   289   290   Human immunoglobulin superfamily protein IGSFP-9       NOV11f   CG51027-09   291   292   Human immunoglobulin superfamily protein IGSFP-9       NOV11g   316763704   293   294   Human immunoglobulin superfamily protein IGSFP-9       NOV11h   CG51027-01   295   296   Human immunoglobulin superfamily protein IGSFP-9       NOV11i   CG51027-02   297   298   Human immunoglobulin superfamily protein IGSFP-9       NOV11j   CG51027-03   299   300   Human immunoglobulin superfamily protein IGSFP-9       NOV11k   CG51027-04   301   302   Human immunoglobulin superfamily protein IGSFP-9       NOV11l   CG51027-05   303   304   Human immunoglobulin superfamily protein IGSFP-9       NOV11m   CG51027-07   305   306   Human immunoglobulin superfamily protein IGSFP-9       NOV11n   CG51027-08   307   308   Human immunoglobulin superfamily protein IGSFP-9       NOV11o   CG51027-10   309   310   Human immunoglobulin superfamily protein IGSFP-9       NOV11p   CG51027-11   311   312   Human immunoglobulin superfamily protein IGSFP-9       NOV11q   CG51027-12   313   314   Human immunoglobulin superfamily protein IGSFP-9       NOV11r   SNP13376340   315   316   Human immunoglobulin superfamily protein IGSFP-9       NOV11s   SNP13376341   317   318   Human immunoglobulin superfamily protein IGSFP-9       NOV12a   CG51373-11   319   320   Human G protein-coupled receptor       NOV12b   CG51373-10   321   322   Human G protein-coupled receptor       NOV12c   CG51373-08   323   324   Human G protein-coupled receptor       NOV12d   237582097   325   326   Human G protein-coupled receptor       NOV12e   294385961   327   328   Human G protein-coupled receptor       NOV12f   294398021   329   330   Human G protein-coupled receptor       NOV12g   CG51373-01   331   332   Human G protein-coupled receptor       NOV12h   CG51373-02   333   334   Human G protein-coupled receptor       NOV12i   CG51373-03   335   336   Human G protein-coupled receptor       NOV12j   CG51373-04   337   338   Human G protein-coupled receptor       NOV12k   CG51373-05   339   340   Human G protein-coupled receptor       NOV12l   CG51373-06   341   342   Human G protein-coupled receptor       NOV12m   CG51373-07   343   344   Human G protein-coupled receptor       NOV12n   CG51373-09   345   346   Human G protein-coupled receptor       NOV12o   CG51373-12   347   348   Human G protein-coupled receptor       NOV12p   CG51373-13   349   350   Human G protein-coupled receptor       NOV12q   CG51373-14   351   352   Human G protein-coupled receptor       NOV12r   SNP13377352   353   354   Human G protein-coupled receptor       NOV12s   SNP13379746   355   356   Human G protein-coupled receptor       NOV12t   SNP13374859   357   358   Human G protein-coupled receptor       NOV12u   SNP13374858   359   360   Human G protein-coupled receptor       NOV12v   SNP13374856   361   362   Human G protein-coupled receptor       NOV12w   SNP13374855   363   364   Human G protein-coupled receptor       NOV12x   SNP13374854   365   366   Human G protein-coupled receptor       NOV12y   SNP13374853   367   368   Human G protein-coupled receptor       NOV13a   CG51622-04   369   370   Von Ebner minor protein -  Homo sapiens         NOV13b   CG51622-03   371   372   Von Ebner minor protein -  Homo sapiens         NOV13c   CG51622-05   373   374   Von Ebner minor protein -  Homo sapiens         NOV13d   CG51622-01   375   376   Von Ebner minor protein -  Homo sapiens         NOV13e   275698370   377   378   Von Ebner minor protein -  Homo sapiens         NOV13f   274054187   379   380   Von Ebner minor protein -  Homo sapiens         NOV13g   CG51622-02   381   382   Von Ebner minor protein -  Homo sapiens         NOV13h   CG51622-06   383   384   Von Ebner minor protein -  Homo sapiens         NOV13i   CG51622-07   385   386   Von Ebner minor protein -  Homo sapiens         NOV13j   CG51622-08   387   388   Von Ebner minor protein -  Homo sapiens         NOV13k   CG51622-09   389   390   Von Ebner minor protein -  Homo sapiens         NOV13l   CG51622-10   391   392   Von Ebner minor protein -  Homo sapiens         NOV13m   SNP13375774   393   394   Von Ebner minor protein -  Homo sapiens         NOV13n   SNP13375775   395   396   Von Ebner minor protein -  Homo sapiens         NOV14a   CG51821-01   397   398   Sialoadhesin precursor (Sialic acid binding Ig-like lectin-1)                       (Siglec- 1) (CD169 antigen) -  Homo sapiens         NOV14b   229823091   399   400   Sialoadhesin precursor (Sialic acid binding Ig-like lectin-1)                       (Siglec- 1) (CD169 antigen) -  Homo sapiens         NOV14c   229823107   401   402   Sialoadhesin precursor (Sialic acid binding Ig-like lectin-1)                       (Siglec- 1) (CD169 antigen) -  Homo sapiens         NOV14d   229823095   403   404   Sialoadhesin precursor (Sialic acid binding Ig-like lectin-1)                       (Siglec- 1) (CD169 antigen) -  Homo sapiens         NOV14e   CG51821-02   405   406   Sialoadhesin precursor (Sialic acid binding Ig-like lectin-1)                       (Siglec- 1) (CD169 antigen) -  Homo sapiens         NOV14f   CG51821-03   407   408   Sialoadhesin precursor (Sialic acid binding Ig-like lectin-1)                       (Siglec- 1) (CD169 antigen) -  Homo sapiens         NOV14g   CG51821-04   409   410   Sialoadhesin precursor (Sialic acid binding Ig-like lectin-1)                       (Siglec- 1) (CD169 antigen) -  Homo sapiens         NOV14h   SNP13382490   411   412   Sialoadhesin precursor (Sialic acid binding Ig-like lectin-1)                       (Siglec- 1) (CD169 antigen) -  Homo sapiens         NOV14i   SNP13382489   413   414   Sialoadhesin precursor (Sialic acid binding Ig-like lectin-1)                       (Siglec- 1) (CD169 antigen) -  Homo sapiens         NOV14j   SNP13377616   415   416   Sialoadhesin precursor (Sialic acid binding Ig-like lectin-1)                       (Siglec- 1) (CD169 antigen) -  Homo sapiens         NOV14k   SNP13377617   417   418   Sialoadhesin precursor (Sialic acid binding Ig-like lectin-1)                       (Siglec- 1) (CD169 antigen) -  Homo sapiens         NOV15a   CG51992-05   419   420   CTCL tumor antigen se57-1 -  Homo sapiens         NOV15b   CG51992-01   421   422   CTCL tumor antigen se57-1 -  Homo sapiens         NOV15c   CG51992-02   423   424   CTCL tumor antigen se57-1 -  Homo sapiens         NOV15d   CG51992-03   425   426   CTCL tumor antigen se57-1 -  Homo sapiens         NOV15e   CG51992-04   427   428   CTCL tumor antigen se57-1 -  Homo sapiens         NOV15f   SNP13382486   429   430   CTCL tumor antigen se57-1 -  Homo sapiens         NOV15g   SNP13382487   431   432   CTCL tumor antigen se57-1 -  Homo sapiens         NOV16a   CG52171-04   433   434   Hematopoietic PBX-interacting protein -  Homo sapiens         NOV16b   CG52171-01   435   436   Hematopoietic PBX-interacting protein -  Homo sapiens         NOV16c   CG52171-02   437   438   Hematopoietic PBX-interacting protein -  Homo sapiens         NOV16d   CG52171-03   439   440   Hematopoietic PBX-interacting protein -  Homo sapiens         NOV16e   CG52171-05   441   442   Hematopoietic PBX-interacting protein -  Homo sapiens         NOV16f   CG52171-06   443   444   Hematopoietic PBX-interacting protein -  Homo sapiens         NOV16g   SNP13374628   445   446   Hematopoietic PBX-interacting protein -  Homo sapiens         NOV16h   SNP13377329   447   448   Hematopoietic PBX-interacting protein -  Homo sapiens         NOV16i   SNP13374627   449   450   Hematopoietic PBX-interacting protein -  Homo sapiens         NOV16j   SNP13374626   451   452   Hematopoietic PBX-interacting protein -  Homo sapiens         NOV16k   SNP13374625   453   454   Hematopoietic PBX-interacting protein - Homo sapiens       NOV16l   SNP13374624   455   456   Hematopoietic PBX-interacting protein -  Homo sapiens         NOV17a   CG52534-06   457   458   Transferrin receptor protein 2 (TfR2) -  Homo sapiens         NOV17b   CG52534-01   459   460   Transferrin receptor protein 2 (TfR2) -  Homo sapiens         NOV17c   CG52534-02   461   462   Transferrin receptor protein 2 (TfR2) -  Homo sapiens         NOV17d   CG52534-03   463   464   Transferrin receptor protein 2 (TfR2) -  Homo sapiens         NOV17e   CG52534-04   465   466   Transferrin receptor protein 2 (TfR2) -  Homo sapiens         NOV17f   CG52534-05   467   468   Transferrin receptor protein 2 (TfR2) -  Homo sapiens         NOV18a   CG52979-03   469   470   G antigen family C 1 protein (Prostate-associated gene protein                       4) (PAGE-4) (PAGE-1) (JM27) (GAGE-9) -  Homo sapiens         NOV18b   CG52979-01   471   472   G antigen family C 1 protein (Prostate-associated gene protein                       4) (PAGE-4) (PAGE-1) (JM27) (GAGE-9) -  Homo sapiens         NOV18c   CG52979-02   473   474   G antigen family C 1 protein (Prostate-associated gene protein                       4) (PAGE-4) (PAGE-1) (JM27) (GAGE-9) -  Homo sapiens         NOV19a   CG52988-02   475   476   G antigen family C 1 protein (Prostate-associated gene protein                       4) (PAGE-4) (PAGE-1) (JM27) (GAGE-9) -  Homo sapiens         NOV19b   CG52988-03   477   478   G antigen family C 1 protein (Prostate-associated gene protein                       4) (PAGE-4) (PAGE-1) (JM27) (GAGE-9) -  Homo sapiens         NOV19c   CG52988-04   479   480   G antigen family C 1 protein (Prostate-associated gene protein                       4) (PAGE-4) (PAGE-1) (JM27) (GAGE-9) -  Homo sapiens         NOV19d   CG52988-06   481   482   G antigen family C 1 protein (Prostate-associated gene protein                       4) (PAGE-4) (PAGE-1) (JM27) (GAGE-9) -  Homo sapiens         NOV19e   CG52988-07   483   484   G antigen family C 1 protein (Prostate-associated gene protein                       4) (PAGE-4) (PAGE-1) (JM27) (GAGE-9) -  Homo sapiens         NOV19f   CG52988-01   485   486   G antigen family C 1 protein (Prostate-associated gene protein                       4) (PAGE-4) (PAGE-1) (JM27) (GAGE-9) -  Homo sapiens         NOV19g   CG52988-05   487   488   G antigen family C 1 protein (Prostate-associated gene protein                       4) (PAGE-4) (PAGE-1) (JM27) (GAGE-9) -  Homo sapiens         NOV20a   CG53449-04   489   490   Butyrophilin like receptor -  Homo sapiens         NOV20b   CG53449-03   491   492   Butyrophilin like receptor -  Homo sapiens         NOV20c   CG53449-01   493   494   Butyrophilin like receptor -  Homo sapiens         NOV20d   CG53449-02   495   496   Butyrophilin like receptor -  Homo sapiens         NOV20e   CG53449-05   497   498   Butyrophilin like receptor -  Homo sapiens         NOV20f   CG53449-06   499   500   Butyrophilin like receptor -  Homo sapiens         NOV20g   SNP13382434   501   502   Butyrophilin like receptor -  Homo sapiens         NOV20h   SNP13382441   503   504   Butyrophilin like receptor -  Homo sapiens         NOV21a   CG53908-01   505   506   Netrin receptor Unc5h1 -  Mus musculus         NOV21b   CG53908-02   507   508   Netrin receptor Unc5h1 -  Mus musculus         NOV21c   306075989   509   510   Netrin receptor Unc5h1 -  Mus musculus         NOV21d   CG53908-03   511   512   Netrin receptor Unc5h1 -  Mus musculus         NOV21e   CG53908-04   513   514   Netrin receptor Unc5h1 -  Mus musculus         NOV21f   CG53908-05   515   516   Netrin receptor Unc5h1 -  Mus musculus         NOV21g   CG53908-06   517   518   Netrin receptor Unc5h1 -  Mus musculus         NOV21h   CG53908-07   519   520   Netrin receptor Unc5h1 -  Mus musculus         NOV21i   SNP13382444   521   522   Netrin receptor Unc5h1 -  Mus musculus         NOV21j   SNP13375491   523   524   Netrin receptor Unc5h1 -  Mus musculus         NOV21k   SNP13375492   525   526   Netrin receptor Unc5h1 -  Mus musculus         NOV21l   SNP13375493   527   528   Netrin receptor Unc5h1 -  Mus musculus         NOV21m   SNP13375135   529   530   Netrin receptor Unc5h1 -  Mus musculus         NOV21n   SNP13375136   531   532   Netrin receptor Unc5h1 -  Mus musculus         NOV21o   SNP13375137   533   534   Netrin receptor Unc5h1 -  Mus musculus         NOV21p   SNP13375138   535   536   Netrin receptor Unc5h1 -  Mus musculus         NOV21q   SNP13375494   537   538   Netrin receptor Unc5h1 -  Mus musculus         NOV21r   SNP13375495   539   540   Netrin receptor Unc5h1 -  Mus musculus         NOV21s   SNP13375140   541   542   Netrin receptor Unc5h1 -  Mus musculus         NOV21t   SNP13375139   543   544   Netrin receptor Unc5h1 -  Mus musculus         NOV21u   SNP13375496   545   546   Netrin receptor Unc5h1 -  Mus musculus         NOV22a   CG53944-02   547   548   human secreted polypeptide -  Homo sapiens         NOV22b   CG53944-01   549   550   human secreted polypeptide -  Homo sapiens         NOV23a   CG54308-04   551   552   Serpin B12 -  Homo sapiens         NOV23b   CG54308-01   553   554   Serpin B12 -  Homo sapiens         NOV23c   CG54308-02   555   556   Serpin B12 -  Homo sapiens         NOV23d   CG54308-03   557   558   Serpin B12 -  Homo sapiens         NOV23e   CG54308-05   559   560   Serpin B12 -  Homo sapiens         NOV24a   CG54764-02   561   562   Calgizzarin (Endothelial monocyte-activating                       polypeptide) (EMAP) -  Mus musculus         NOV24b   CG54764-01   563   564   Calgizzarin (Endothelial monocyte-activating                       polypeptide) (EMAP) -  Mus musculus         NOV25a   CG55033-04   565   566   Human toll like receptor like molecule 5 (TLR-L5)       NOV25b   CG55033-05   567   568   Human toll like receptor like molecule 5 (TLR-L5)       NOV25c   CG55033-01   569   570   Human toll like receptor like molecule 5 (TLR-L5)       NOV25d   237376826   571   572   Human toll like receptor like molecule 5 (TLR-L5)       NOV25e   310658403   573   574   Human toll like receptor like molecule 5 (TLR-L5)       NOV25f   317980876   575   576   Human toll like receptor like molecule 5 (TLR-L5)       NOV25g   318018151   577   578   Human toll like receptor like molecule 5 (TLR-L5)       NOV25h   318176316   579   580   Human toll like receptor like molecule 5 (TLR-L5)       NOV25i   CG55033-02   581   582   Human toll like receptor like molecule 5 (TLR-L5)       NOV25j   CG55033-03   583   584   Human toll like receptor like molecule 5 (TLR-L5)       NOV25k   CG55033-06   585   586   Human toll like receptor like molecule 5 (TLR-L5)       NOV25l   CG55033-07   587   588   Human toll like receptor like molecule 5 (TLR-L5)       NOV25m   CG55033-08   589   590   Human toll like receptor like molecule 5 (TLR-L5)       NOV25n   CG55033-09   591   592   Human toll like receptor like molecule 5 (TLR-L5)       NOV25o   CG55033-10   593   594   Human toll like receptor like molecule 5 (TLR-L5)       NOV25p   CG55033-11   595   596   Human toll like receptor like molecule 5 (TLR-L5)       NOV25q   CG55033-12   597   598   Human toll like receptor like molecule 5 (TLR-L5)       NOV25r   CG55033-13   599   600   Human toll like receptor like molecule 5 (TLR-L5)       NOV25s   CG55033-14   601   602   Human toll like receptor like molecule 5 (TLR-L5)       NOV26a   CG55117-04   603   604   Prominin-like protein 1 precursor                       (Antigen AC133) (CD133 antigen) -  Homo sapiens         NOV26b   CG55117-01   605   606   Prominin-like protein 1 precursor                       (Antigen AC133) (CD133 antigen) -  Homo sapiens         NOV26c   CG55117-02   607   608   Prominin-like protein 1 precursor                       (Antigen AC133) (CD133 antigen) -  Homo sapiens         NOV26d   CG55117-03   609   610   Prominin-like protein 1 precursor                       (Antigen AC133) (CD133 antigen) -  Homo sapiens         NOV26e   CG55117-05   611   612   Prominin-like protein 1 precursor                       (Antigen AC133) (CD133 antigen) -  Homo sapiens         NOV26f   SNP13382440   613   614   Prominin-like protein 1 precursor                       (Antigen AC133) (CD133 antigen) -  Homo sapiens         NOV26g   SNP13382439   615   616   Prominin-like protein 1 precursor                       (Antigen AC133) (CD133 antigen) -  Homo sapiens         NOV27a   CG55193-04   617   618   PLVAP protein -  Homo sapiens  (Human), 455 aa       NOV27b   214575880   619   620   PLVAP protein -  Homo sapiens  (Human), 455 aa       NOV27c   214458684   621   622   PLVAP protein -  Homo sapiens  (Human), 455 aa       NOV27d   214458688   623   624   PLVAP protein -  Homo sapiens  (Human), 455 aa       NOV27e   CG55193-01   625   626   PLVAP protein -  Homo sapiens  (Human), 455 aa       NOV27f   CG55193-02   627   628   PLVAP protein -  Homo sapiens  (Human), 455 aa       NOV27g   CG55193-03   629   630   PLVAP protein -  Homo sapiens  (Human), 455 aa       NOV27h   CG55193-05   631   632   PLVAP protein -  Homo sapiens  (Human), 455 aa       NOV27i   CG55193-06   633   634   PLVAP protein -  Homo sapiens  (Human), 455 aa       NOV27j   CG55193-07   635   636   PLVAP protein -  Homo sapiens  (Human), 455 aa       NOV28a   CG55256-07   637   638   Apolipoprotein E receptor 2 precursor -  Homo sapiens         NOV28b   CG55256-10   639   640   Apolipoprotein E receptor 2 precursor -  Homo sapiens         NOV28c   272511714   641   642   Apolipoprotein E receptor 2 precursor -  Homo sapiens         NOV28d   CG55256-01   643   644   Apolipoprotein E receptor 2 precursor -  Homo sapiens         NOV28e   CG55256-02   645   646   Apolipoprotein E receptor 2 precursor -  Homo sapiens         NOV28f   CG55256-03   647   648   Apolipoprotein E receptor 2 precursor -  Homo sapiens         NOV28g   CG55256-04   649   650   Apolipoprotein E receptor 2 precursor -  Homo sapiens         NOV28h   CG55256-05   621   652   Apolipoprotein E receptor 2 precursor -  Homo sapiens         NOV28i   CG55256-06   653   654   Apolipoprotein E receptor 2 precursor -  Homo sapiens         NOV28j   CG55256-08   655   656   Apolipoprotein E receptor 2 precursor -  Homo sapiens         NOV28k   CG55256-09   657   658   Apolipoprotein E receptor 2 precursor -  Homo sapiens         NOV28l   CG55256-11   659   660   Apolipoprotein E receptor 2 precursor -  Homo sapiens         NOV28m   SNP13382497   661   662   Apolipoprotein E receptor 2 precursor -  Homo sapiens         NOV28n   SNP13382498   663   664   Apolipoprotein E receptor 2 precursor -  Homo sapiens         NOV29a   CG55776-01   665   666   Human osteoclast protein (OCP)       NOV29b   248210167   667   668   Human osteoclast protein (OCP)       NOV29c   247679561   669   670   Human osteoclast protein (OCP)       NOV29d   248057904   671   672   Human osteoclast protein (OCP)       NOV29e   248057927   673   674   Human osteoclast protein (OCP)       NOV29f   249239821   675   676   Human osteoclast protein (OCP)       NOV29g   248057920   677   678   Human osteoclast protein (OCP)       NOV29h   247679541   679   680   Human osteoclast protein (OCP)       NOV29i   249116954   681   682   Human osteoclast protein (OCP)       NOV29j   248210155   683   684   Human osteoclast protein (OCP)       NOV29k   248213764   685   686   Human osteoclast protein (OCP)       NOV29l   248213768   687   688   Human osteoclast protein (OCP)       NOV29m   248213772   689   690   Human osteoclast protein (OCP)       NOV29n   248586774   691   692   Human osteoclast protein (OCP)       NOV29o   248586793   693   694   Human osteoclast protein (OCP)       NOV29p   248586820   695   696   Human osteoclast protein (OCP)       NOV29q   248586824   697   698   Human osteoclast protein (OCP)       NOV29r   247679817   699   700   Human osteoclast protein (OCP)       NOV29s   248210264   701   702   Human osteoclast protein (OCP)       NOV29t   248210551   703   704   Human osteoclast protein (OCP)       NOV29u   248210824   705   706   Human osteoclast protein (OCP)       NOV29v   248679541   707   708   Human osteoclast protein (OCP)       NOV29w   247679454   709   710   Human osteoclast protein (OCP)       NOV29x   314361407   711   712   Human osteoclast protein (OCP)       NOV29y   317803448   713   714   Human osteoclast protein (OCP)       NOV29z   CG55776-02   715   716   Human osteoclast protein (OCP)       NOV29aa   CG55776-03   717   718   Human osteoclast protein (OCP)       NOV29ab   CG55776-04   719   720   Human osteoclast protein (OCP)       NOV29ac   CG55776-05   721   722   Human osteoclast protein (OCP)       NOV29ad   CG55776-06   723   724   Human osteoclast protein (OCP)       NOV29ae   CG55776-07   725   726   Human osteoclast protein (OCP)       NOV29af   CG55776-08   727   728   Human osteoclast protein (OCP)       NOV29ag   CG55776-09   729   730   Human osteoclast protein (OCP)       NOV29ah   SNP13376522   731   732   Human osteoclast protein (OCP)       NOV29ai   SNP13377624   733   734   Human osteoclast protein (OCP)       NOV29aj   SNP13377625   735   736   Human osteoclast protein (OCP)       NOV29ak   SNP13376523   737   738   Human osteoclast protein (OCP)       NOV29al   SNP13376524   739   740   Human osteoclast protein (OCP)       NOV29am   SNP13376525   741   742   Human osteoclast protein (OCP)       NOV29an   SNP13376526   743   744   Human osteoclast protein (OCP)       NOV29ao   SNP13377626   745   746   Human osteoclast protein (OCP)       NOV29ap   SNP13377641   747   748   Human osteoclast protein (OCP)       NOV29aq   SNP13377640   749   750   Human osteoclast protein (OCP)       NOV30a   CG55784-03   751   752   NPEH2 -  Homo sapiens         NOV30b   CG55784-01   753   754   NPEH2 -  Homo sapiens         NOV30c   312000579   755   756   NPEH2 -  Homo sapiens         NOV30d   311333341   757   758   NPEH2 -  Homo sapiens         NOV30e   311333338   759   760   NPEH2 -  Homo sapiens         NOV30f   311346885   761   762   NPEH2 -  Homo sapiens         NOV30g   311333299   763   764   NPEH2 -  Homo sapiens         NOV30h   CG55784-02   765   766   NPEH2 -  Homo sapiens         NOV30i   SNP13376439   767   768   NPEH2 -  Homo sapiens         NOV31a   CG55790-02   769   770   ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like                       protein G150) (B7-related protein-1) (B7RP-1) -  Homo sapiens         NOV31b   258668431   771   772   ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like                       protein G150) (B7-related protein-1) (B7RP-1) -  Homo sapiens         NOV31c   309303509   773   774   ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like                       protein G150) (B7-related protein-1) (B7RP-1) -  Homo sapiens         NOV31d   315925314   775   776   ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like                       protein G150) (B7-related protein-1) (B7RP-1) -  Homo sapiens         NOV31e   315970230   777   778   ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like                       protein G150) (B7-related protein-1) (B7RP-1) -  Homo sapiens         NOV31f   CG55790-01   779   780   ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like                       protein G150) (B7-related protein-1) (B7RP-1) -  Homo sapiens         NOV31g   CG55790-03   781   782   ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like                       protein G150) (B7-related protein-1) (B7RP-1) -  Homo sapiens         NOV31h   CG55790-04   783   784   ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like                       protein G150) (B7-related protein-1) (B7RP-1) -  Homo sapiens         NOV31i   CG55790-05   785   786   ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like                       protein G150) (B7-related protein-1) (B7RP-1) -  Homo sapiens         NOV31j   CG55790-06   787   788   ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like                       protein G150) (B7-related protein-1) (B7RP-1) -  Homo sapiens         NOV31k   CQ55790-07   789   790   ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like                       protein G150) (B7-related protein-1) (B7RP-1) -  Homo sapiens         NOV31l   SNP13374852   791   792   ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like                       protein G150) (B7-related protein-1) (B7RP-1) -  Homo sapiens         NOV32a   CG55906-04   793   794   Human breast tumour-associated protein 37       NOV32b   CG55906-05   795   796   Human breast tumour-associated protein 37       NOV32c   CG55906-01   797   798   Human breast tumour-associated protein 37       NOV32d   277901794   799   800   Human breast tumour-associated protein 37       NOV32e   CG55906-02   801   802   Human breast tumour-associated protein 37       NOV32f   230272941   803   804   Human breast tumour-associated protein 37       NOV32g   CG55906-03   805   806   Human breast tumour-associated protein 37       NOV32h   SNP13382505   807   808   Human breast tumour-associated protein 37       NOV32i   SNP13382504   809   810   Human breast tumour-associated protein 37       NOV32j   SNP13376440   811   812   Human breast tumour-associated protein 37       NOV33a   CG55908-01   813   814   integrin alpha-7 chain precursor - human       NOV33b   253116407   815   816   integrin alpha-7 chain precursor - human       NOV33c   253116412   817   818   integrin alpha-7 chain precursor - human       NOV34a   CG56077-06   819   820   LGI4 (Leucine-rich glioma inactivated protein 4)                       (LGI1-like protein 3) -  Homo sapiens         NOV34b   CG56077-01   821   822   LGI4 (Leucine-rich glioma inactivated protein 4)                       (LGI1-like protein 3) -  Homo sapiens         NOV34c   CG56077-02   823   824   LGI4 (Leucine-rich glioma inactivated protein 4)                       (LGI1-like protein 3) -  Homo sapiens         NOV34d   CG56077-03   825   826   LGI4 (Leucine-rich glioma inactivated protein 4)                       (LGI1-like protein 3) -  Homo sapiens         NOV34e   CG56077-04   827   828   LGI4 (Leucine-rich glioma inactivated protein 4)                       (LGI1-like protein 3) -  Homo sapiens         NOV34f   CG56077-05   829   830   LGI4 (Leucine-rich glioma inactivated protein 4)                       (LGI1-like protein 3) -  Homo sapiens         NOV34g   SNP13374715   831   832   LGI4 (Leucine-rich glioma inactivated protein 4)                       (LGI1-like protein 3) -  Homo sapiens         NOV34h   SNP13374714   833   834   LGI4 (Leucine-rich glioma inactivated protein 4)                       (LGI1-like protein 3) -  Homo sapiens         NOV35a   CG56110-03   835   836   B7-H1 (PD-1-ligand precursor) -  Homo sapiens         NOV35b   CG56110-07   837   838   B7-H1 (PD-1-ligand precursor) -  Homo sapiens         NOV35c   274082305   839   840   B7-H1 (PD-1-ligand precursor) -  Homo sapiens         NOV35d   CG56110-01   841   842   B7-H1 (PD-1-ligand precursor) -  Homo sapiens         NOV35e   CG56110-02   843   844   B7-H1 (PD-1-ligand precursor) -  Homo sapiens         NOV35f   CG56110-04   845   846   B7-H1 (PD-1-ligand precursor) -  Homo sapiens         NOV35g   CG56110-05   847   848   B7-H1 (PD-1-ligand precursor) -  Homo sapiens         NOV35h   CG56110-06   849   850   B7-H1 (PD-1-ligand precursor) -  Homo sapiens         NOV36a   CG56383-02   851   852   Prickle-like 1 ( Drosophila ) -  Mus musculus  (Mouse), 879 aa       NOV36b   CG56383-01   853   854   Prickle-like 1 ( Drosophila ) -  Mus musculus  (Mouse), 879 aa       NOV36c   SNP13382513   855   856   Prickle-like 1 ( Drosophila ) -  Mus musculus  (Mouse), 879 aa       NOV37a   CG56449-04   857   858   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV37b   CG56449-09   859   860   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV37c   191887507   861   862   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV37d   316351371   863   864   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV37e   316935396   865   866   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV37f   317004318   867   868   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV37g   CG56449-01   869   870   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV37h   CG56449-02   871   872   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV37i   CG56449-03   873   874   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV37j   CG56449-05   875   876   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV37k   CG56449-06   877   878   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV37l   CG56449-07   879   880   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV37m   CG56449-08   881   882   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV37n   CG56449-10   883   884   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV37o   CG56449-11   885   886   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV37p   SNP13382514   887   888   MEGF6 -  Homo sapiens  (Human), 1246 aa       NOV38a   CG56594-01   889   890   Claudin-19 -  Homo sapiens         NOV38b   277685552   891   892   Claudin-19 -  Homo sapiens         NOV38c   277685649   893   894   Claudin-19 -  Homo sapiens         NOV38d   277685616   895   896   Claudin-19 -  Homo sapiens         NOV39a   CG56653-08   897   898   ficolin-1 precursor       NOV39b   214374274   899   900   ficolin-1 precursor       NOV39c   214374256   901   902   ficolin-1 precursor       NOV39d   214374252   903   904   ficolin-1 precursor       NOV39e   214458492   905   906   ficolin-1 precursor       NOV39f   214458488   907   908   ficolin-1 precursor       NOV39g   214374236   909   910   ficolin-1 precursor       NOV39h   CG56653-01   911   912   ficolin-1 precursor       NOV39i   CG56653-02   913   914   ficolin-1 precursor       NOV39j   CG56653-03   915   916   ficolin-1 precursor       NOV39k   CG56653-04   917   918   ficolin-1 precursor       NOV39l   CG56653-05   919   920   ficolin-1 precursor       NOV39m   CG56653-06   921   922   ficolin-1 precursor       NOV39n   CG56653-07   923   924   ficolin-1 precursor       NOV39o   CG56653-09   925   926   ficolin-1 precursor       NOV39p   CG56653-10   927   928   ficolin-1 precursor       NOV39q   CG56653-11   929   930   ficolin-1 precursor       NOV39r   CG56653-12   931   932   ficolin-1 precursor       NOV40a   CG56806-01   933   934   Heparan sulfate 6-O-sulfotransferase 3 -  Homo sapiens         NOV40b   248061366   935   936   Heparan sulfate 6-O-sulfotransferase 3 -  Homo sapiens         NOV40c   246837961   937   938   Heparan sulfate 6-O-sulfotransferase 3 -  Homo sapiens         NOV40d   246837965   939   940   Heparan sulfate 6-O-sulfotransferase 3 -  Homo sapiens         NOV40e   246837975   941   942   Heparan sulfate 6-O-sulfotransferase 3 -  Homo sapiens         NOV40f   248061376   943   944   Heparan sulfate 6-O-sulfotransferase 3 -  Homo sapiens         NOV40g   SNP13381685   945   946   Heparan sulfate 6-O-sulfotransferase 3 -  Homo sapiens         NOV40h   SNP13381686   947   948   Heparan sulfate 6-O-sulfotransferase 3 -  Homo sapiens         NOV41a   CG56878-01   949   950   Protein OS-9 precursor -  Homo sapiens         NOV41b   175070399   951   952   Protein OS-9 precursor -  Homo sapiens         NOV41c   175070432   953   954   Protein OS-9 precursor -  Homo sapiens         NOV41d   175070419   955   956   Protein OS-9 precursor -  Homo sapiens         NOV41e   175070438   957   958   Protein OS-9 precursor -  Homo sapiens         NOV41f   175070408   959   960   Protein OS-9 precursor -  Homo sapiens         NOV41g   CG56878-02   961   962   Protein OS-9 precursor -  Homo sapiens         NOV41h   CG56878-03   963   964   Protein OS-9 precursor -  Homo sapiens         NOV41i   CG56878-04   965   966   Protein OS-9 precursor -  Homo sapiens         NOV41j   SNP13382511   967   968   Protein OS-9 precursor -  Homo sapiens         NOV41k   SNP13382506   969   970   Protein OS-9 precursor -  Homo sapiens         NOV42a   CG56904-01   971   972   secreted protein LP255(a)       NOV42b   272355087   973   974   secreted protein LP255(a)       NOV42c   246862506   975   976   secreted protein LP255(a)       NOV42d   CG56904-04   977   978   secreted protein LP255(a)       NOV42e   268824694   979   980   secreted protein LP255(a)       NOV42f   283146542   981   982   secreted protein LP255(a)       NOV42g   308521214   983   984   secreted protein LP255(a)       NOV42h   CG56904-02   985   986   secreted protein LP255(a)       NOV42i   CG56904-03   987   988   secreted protein LP255(a)       NOV42j   CG56904-05   989   990   secreted protein LP255(a)       NOV42k   CG56904-06   991   992   secreted protein LP255(a)       NOV42l   CG56904-07   993   994   secreted protein LP255(a)       NOV42m   CG56904-08   995   996   secreted protein LP255(a)       NOV43a   CG56914-01   997   998   Hemicentin -  Homo sapiens         NOV43b   262802367   999   1000   Hemicentin -  Homo sapiens         NOV43c   CG56914-02   1001   1002   Hemicentin -  Homo sapiens         NOV43d   CG56914-03   1003   1004   Hemicentin -  Homo sapiens         NOV44a   CG56959-02   1005   1006   Synaptotagmin 10 -  Rattus norvegicus         NOV44b   CG56959-01   1007   1008   Synaptotagmin 10 -  Rattus norvegicus         NOV45a   CG57111-01   1009   1010   Protocadherin 13 -  Homo sapiens  (Human), 947 aa       NOV45b   277726328   1011   1012   Protocadherin 13 -  Homo sapiens  (Human), 947 aa       NOV45c   CG57111-02   1013   1014   Protocadherin 13 -  Homo sapiens  (Human), 947 aa       NOV45d   CG57111-03   1015   1016   Protocadherin 13 -  Homo sapiens  (Human), 947 aa       NOV45e   CG57111-04   1017   1018   Protocadherin 13 -  Homo sapiens  (Human), 947 aa       NOV46a   CG57409-05   1019   1020   Glycosyl-phosphatidyl-inositol-MAM -  Homo sapiens         NOV46b   277731446   1021   1022   Glycosyl-phosphatidyl-inositol-MAM -  Homo sapiens         NOV46c   CG57409-07   1023   1024   Glycosyl-phosphatidyl-inositol-MAM -  Homo sapiens         NOV46d   312102874   1025   1026   Glycosyl-phosphatidyl-inositol-MAM -  Homo sapiens         NOV46e   312102899   1027   1028   Glycosyl-phosphatidyl-inositol-MAM -  Homo sapiens         NOV46f   CG57409-01   1029   1030   Glycosyl-phosphatidyl-inositol-MAM -  Homo sapiens         NOV46g   CG57409-02   1031   1032   Glycosyl-phosphatidyl-inositol-MAM -  Homo sapiens         NOV46h   CG57409-03   1033   1034   Glycosyl-phosphatidyl-inositol-MAM -  Homo sapiens         NOV46i   CG57409-04   1035   1036   Glycosyl-phosphatidyl-inositol-MAM -  Homo sapiens         NOV46j   CG57409-06   1037   1038   Glycosyl-phosphatidyl-inositol-MAM -  Homo sapiens         NOV46k   CG57409-08   1039   1040   Glycosyl-phosphatidyl-inositol-MAM -  Homo sapiens         NOV47a   CG57448-01   1041   1042   Human cadherin-1 (CDHN-1) protein       NOV47b   247846705   1043   1044   Human cadherin-1 (CDHN-1) protein       NOV47c   247846708   1045   1046   Human cadherin-1 (CDHN-1) protein       NOV47d   237580295   1047   1048   Human cadherin-1 (CDHN-1) protein       NOV47e   237579512   1049   1050   Human cadherin-1 (CDHN-1) protein       NOV47f   CG57448-02   1051   1052   Human cadherin-1 (CDHN-1) protein       NOV48a   CG57574-03   1053   1054   Tectorin beta -  Homo sapiens         NOV48b   CG57574-01   1055   1056   Tectorin beta -  Homo sapiens         NOV48c   CG57574-02   1057   1058   Tectorin beta -  Homo sapiens         NOV48d   CG57574-04   1059   1060   Tectorin beta -  Homo sapiens         NOV48e   CG57574-05   1061   1062   Tectorin beta -  Homo sapiens         NOV49a   CG57689-01   1063   1064   Inferred: hemicentin -  Mus musculus         NOV50a   CG58567-01   1065   1066   Human cadherin (CAD) protein       NOV50b   220087646   1067   1068   Human cadherin (CAD) protein       NOV50c   194877960   1069   1070   Human cadherin (CAD) protein       NOV50d   192589297   1071   1072   Human cadherin (CAD) protein       NOV50e   CG58567-02   1073   1074   Human cadherin (CAD) protein       NOV50f   CG58567-03   1075   1076   Human cadherin (CAD) protein       NOV50g   CG58567-04   1077   1078   Human cadherin (CAD) protein       NOV50h   CG58567-05   1079   1080   Human cadherin (CAD) protein       NOV50i   CG58567-06   1081   1082   Human cadherin (CAD) protein       NOV51a   CG59534-03   1083   1084   Membrane glycoprotein LIG-1 -  Homo sapiens         NOV51b   CG59534-01   1085   1086   Membrane glycoprotein LIG-1 -  Homo sapiens         NOV51c   CG59534-02   1087   1088   Membrane glycoprotein LIG-1 -  Homo sapiens         NOV51d   SNP13377255   1089   1090   Membrane glycoprotein LIG-1 -  Homo sapiens         NOV52a   CG59584-03   1091   1092   Ovostatin precursor (Ovomacroglobulin) -  Gallus gallus         NOV52b   CG59584-02   1093   1094   Ovostatin precursor (Ovomacroglobulin) -  Gallus gallus         NOV52c   248210405   1095   1096   Ovostatin precursor (Ovomacroglobulin) -  Gallus gallus         NOV52d   248210436   1097   1098   Ovostatin precursor (Ovomacroglobulin) -  Gallus gallus         NOV52e   249357737   1099   1100   Ovostatin precursor (Ovomacroglobulin) -  Gallus gallus         NOV52f   248210430   1101   1102   Ovostatin precursor (Ovomacroglobulin) -  Gallus gallus         NOV52g   249357755   1103   1104   Ovostatin precursor (Ovomacroglobulin) -  Gallus gallus         NOV52h   CG59584-01   1105   1106   Ovostatin precursor (Ovomacroglobulin) -  Gallus gallus         NOV53a   CG56008-01   1107   1108       NOV54a   CG59905-01   1109   1110   CUB and sushi multiple domains 1 protein -  Homo sapiens         NOV54b   CG59905-03   1111   1112   CUB and sushi multiple domains 1 protein -  Homo sapiens         NOV54c   275631102   1113   1114   CUB and sushi multiple domains 1 protein -  Homo sapiens         NOV54d   CG59905-02   1115   1116   CUB and sushi multiple domains 1 protein -  Homo sapiens         NOV54e   SNP13382527   1117   1118   CUB and sushi multiple domains 1 protein -  Homo sapiens         NOV54f   SNP13382520   1119   1120   CUB and sushi multiple domains 1 protein -  Homo sapiens         NOV55a   CG59932-01   1121   1122   secreted protein sequence       NOV56a   CG92715-01   1123   1124   secreted protein sequence       NOV56b   248576233   1125   1126   secreted protein sequence       NOV56c   CG92715-02   1127   1128   secreted protein sequence       NOV56d   CG92715-03   1129   1130   secreted protein sequence       NOV57a   CG92813-01   1131   1132   Cadherin-related tumor suppressor precursor (Fat protein) -                         Drosophila melanogaster         NOV57b   260500971   1133   1134   Cadherin-related tumor suppressor precursor (Fat protein) -                         Drosophila melanogaster         NOV57c   260500961   1135   1136   Cadherin-related tumor suppressor precursor (Fat protein) -                         Drosophila melanogaster         NOV57d   258076331   1137   1138   Cadherin-related tumor suppressor precursor (Fat protein) -                         Drosophila melanogaster         NOV57e   258076349   1139   1140   Cadherin-related tumor suppressor precursor (Fat protein) -                         Drosophila melanogaster         NOV57f   CG92813-02   1141   1142   Cadherin-related tumor suppressor precursor (Fat protein) -                         Drosophila melanogaster         NOV58a   CG93387-05   1143   1144   insulin-responsive sequence DNA binding protein-1 -  Homo sapiens         NOV58b   CG93387-01   1145   1146   insulin-responsive sequence DNA winding protein-1 -  Homo sapiens         NOV58c   CG93387-02   1147   1148   insulin-responsive sequence DNA binding protein-1 -  Homo sapiens         NOV58d   CG93387-03   1149   1150   insulin-responsive sequence DNA winding protein-1 -  Homo sapiens         NOV58e   CG93387-04   1151   1152   insulin-responsive sequence DNA binding protein-1 -  Homo sapiens         NOV58f   SNP13382519   1153   1154   insulin-responsive sequence DNA winding protein-1 -  Homo sapiens         NOV59a   CG93871-01   1155   1156   insulin-responsive sequence DNA binding protein-1 -  Homo sapiens         NOV59b   CG93871-05   1157   1158   insulin-responsive sequence DNA winding protein-1 -  Homo sapiens         NOV59c   198488432   1159   1160   insulin-responsive sequence DNA binding protein-1 -  Homo sapiens         NOV59d   198488424   1161   1162   insulin-responsive sequence DNA winding protein-1 -  Homo sapiens         NOV59e   198488428   1163   1164   insulin-responsive sequence DNA binding protein-1 -  Homo sapiens         NOV59f   198488440   1165   1166   insulin-responsive sequence DNA winding protein-1 -  Homo sapiens         NOV59g   CG93871-02   1167   1168   insulin-responsive sequence DNA binding protein-1 -  Homo sapiens         NOV59h   CG93871-03   1169   1170   insulin-responsive sequence DNA winding protein-1 -  Homo sapiens         NOV59i   CG93871-04   1171   1172   insulin-responsive sequence DNA binding protein-1 -  Homo sapiens         NOV60a   CG94946-01   1173   1174   AGRIN precursor -  Homo sapiens  (Human), 2026 aa       NOV60b   275631590   1175   1176   AGRIN precursor -  Homo sapiens  (Human), 2026 aa       NOV60c   275631564   1177   1178   AGRIN precursor -  Homo sapiens  (Human), 2026 aa       NOV60d   CG94946-02   1179   1180   AGRIN precursor -  Homo sapiens  (Human), 2026 aa       NOV60e   CG94946-03   1181   1182   AGRIN precursor -  Homo sapiens  (Human), 2026 aa       NOV60f   CG94946-04   1183   1184   AGRIN precursor -  Homo sapiens  (Human), 2026 aa       NOV60g   CG94946-05   1185   1186   AGRIN precursor -  Homo sapiens  (Human), 2026 aa       NOV60h   CG94946-06   1187   1188   AGRIN precursor -  Homo sapiens  (Human), 2026 aa       NOV60i   CG94946-07   1189   1190   AGRIN precursor -  Homo sapiens  (Human), 2026 aa       NOV61a   CG96384-01   1191   1192   colon cancer antigen protein       NOV61b   277580745   1193   1194   colon cancer antigen protein       NOV61c   CG96384-02   1195   1196   colon cancer antigen protein       NOV61d   CG96384-03   1197   1198   colon cancer antigen protein       NOV61e   CG96384-04   1199   1200   colon cancer antigen protein       NOV62a   CG98011-01   1201   1202   Neuronal transmembrane protein Slitrk4 -  Mus musculus         NOV62b   192586956   1203   1204   Neuronal transmembrane protein Slitrk4 -  Mus musculus         NOV62c   191999007   1205   1206   Neuronal transmembrane protein Slitrk4 -  Mus musculus         NOV62d   CG98011-02   1207   1208   Neuronal transmembrane protein Slitrk4 -  Mus musculus         NOV62e   CG98011-03   1209   1210   Neuronal transmembrane protein Slitrk4 -  Mus musculus         NOV62f   CG98011-04   1211   1212   Neuronal transmembrane protein Slitrk4 -  Mus musculus                    
 
      Table A indicates the homology of NOVX polypeptides to known protein families. Thus, the nucleic acids and polypeptides, antibodies and related compounds according to the invention corresponding to a NOVX as identified in column 1 of Table A will be useful in therapeutic and diagnostic applications implicated in, for example, pathologies and disorders associated with the known protein families identified in column 5 of Table A.  
      Pathologies, diseases, disorders and condition and the like that are associated with NOVX sequences include, but are not limited to: e.g., cardiomyopathy, atherosclerosis, hypertension, congenital heart defects, aortic stenosis, atrial septal defect (ASD), vascular calcification, fibrosis, atrioventricular (A-V) canal defect, ductus arteriosus, pulmonary stenosis, subaortic stenosis, ventricular septal defect (VSD), valve diseases, tuberous sclerosis, scleroderma, obesity, metabolic disturbances associated with obesity, transplantation, osteoarthritis, rheumatoid arthritis, osteochondrodysplasia, adrenoleukodystrophy, congenital adrenal hyperplasia, prostate cancer, diabetes, metabolic disorders, neoplasm; adenocarcinoma, lymphoma, uterus cancer, fertility, glomerulonephritis, hemophilia, hypercoagulation, idiopathic thrombocytopenic purpura, immunodeficiencies, psoriasis, skin disorders, graft versus host disease, AIDS, bronchial asthma, lupus, Crohn&#39;s disease; inflammatory bowel disease, ulcerative colitis, multiple sclerosis, treatment of Albright Hereditary Ostoeodystrophy, infectious disease, anorexia, cancer-associated cachexia, cancer, neurodegenerative disorders, Alzheimer&#39;s Disease, Parkinson&#39;s Disorder, immune disorders, hematopoietic disorders, and the various dyslipidemias, schizophrenia, depression, asthma, emphysema, allergies, the metabolic syndrome X and wasting disorders associated with chronic diseases and various cancers, as well as conditions such as transplantation, neuroprotection, fertility, or regeneration (in vitro and in vivo).  
      NOVX nucleic acids and their encoded polypeptides are useful in a variety of applications and contexts. The various NOVX nucleic acids and polypeptides according to the invention are useful as novel members of the protein families according to the presence of domains and sequence relatedness to previously described proteins. Additionally, NOVX nucleic acids and polypeptides can also be used to identify proteins that are members of the family to which the NOVX polypeptides belong.  
      Consistent with other known members of the family of proteins, identified in column 5 of Table A, the NOVX polypeptides of the present invention show homology to, and contain domains that are characteristic of, other members of such protein families. Details of the sequence relatedness and domain analysis for each NOVX are presented in Example A.  
      The NOVX nucleic acids and polypeptides can also be used to screen for molecules, which inhibit or enhance NOVX activity or function. Specifically, the nucleic acids and polypeptides according to the invention may be used as targets for the identification of small molecules that modulate or inhibit diseases associated with the protein families listed in Table A.  
      The NOVX nucleic acids and polypeptides are also useful for detecting specific cell types. Details of the expression analysis for each NOVX are presented in Example C. Accordingly, the NOVX nucleic acids, polypeptides, antibodies and related compounds according to the invention will have diagnostic and therapeutic applications in the detection of a variety of diseases with differential expression in normal vs. diseased tissues, e.g. detection of a variety of cancers.  
      Additional utilities for NOVX nucleic acids and polypeptides according to the invention are disclosed herein.  
      NOVX Clones  
      NOVX nucleic acids and their encoded polypeptides are useful in a variety of applications and contexts. The various NOVX nucleic acids and polypeptides according to the invention are useful as novel members of the protein families according to the presence of domains and sequence relatedness to previously described proteins. Additionally, NOVX nucleic acids and polypeptides can also be used to identify proteins that are members of the family to which the NOVX polypeptides belong.  
      The NOVX genes and their corresponding encoded proteins are useful for preventing, treating or ameliorating medical conditions, e.g., by protein or gene therapy. Pathological conditions can be diagnosed by determining the amount of the new protein in a sample or by determining the presence of mutations in the new genes. Specific uses are described for each of the NOVX genes, based on the tissues in which they are most highly expressed. Uses include developing products for the diagnosis or treatment of a variety of diseases and disorders.  
      The NOVX nucleic acids and proteins of the invention are useful in potential diagnostic and therapeutic applications and as a research tool. These include serving as a specific or selective nucleic acid or protein diagnostic and/or prognostic marker, wherein the presence or amount of the nucleic acid or the protein are to be assessed, as well as potential therapeutic applications such as the following: (i) a protein therapeutic, (ii) a small molecule drug target, (iii) an antibody target (therapeutic, diagnostic, drug targeting/cytotoxic antibody), (iv) a nucleic acid useful in gene therapy (gene delivery/gene ablation), and (v) a composition promoting tissue regeneration in vitro and in vivo (vi) a biological defense weapon.  
      In one specific embodiment, the invention includes an isolated polypeptide comprising an amino acid sequence selected from the group consisting of: (a) a mature form of the amino acid sequence selected from the group consisting of SEQ ID NO: 2n, wherein n is an integer between 1 and 606; (b) a variant of a mature form of the amino acid sequence selected from the group consisting of SEQ ID NO: 2n, wherein n is an integer between 1 and 606, wherein any amino acid in the mature form is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence of the mature form are so changed; (c) an amino acid sequence selected from the group consisting of SEQ ID NO: 2n, wherein n is an integer between 1 and 606; (d) a variant of the amino acid sequence selected from the group consisting of SEQ ID NO:2n, wherein n is an integer between 1 and 606 wherein any amino acid specified in the chosen sequence is changed to a different amino acid,.provided that no more than 15% of the amino acid residues in the sequence are so changed; and (e) a fragment of any of (a) through (d).  
      In another specific embodiment, the invention includes an isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of: (a) a mature form of the amino acid sequence given SEQ ID NO: 2n, wherein n is an integer between 1 and 606; (b) a variant of a mature form of the amino acid sequence selected from the group consisting of SEQ ID NO: 2n, wherein n is an integer between 1 and 606 wherein any amino acid in the mature form of the chosen sequence is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence of the mature form are so changed; (c) the amino acid sequence selected from the group consisting of SEQ ID NO: 2n, wherein n is an integer between 1 and 606; (d) a variant of the amino acid sequence selected from the group consisting of SEQ ID NO: 2n, wherein n is an integer between 1 and 606, in which any amino acid specified in the chosen sequence is changed to a different amino acid, provided that no more than 15% of the amino acid residues in the sequence are so changed; (e) a nucleic acid fragment encoding at least a portion of a polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NO: 2n, wherein n is an integer between 1 and 606 or any variant of said polypeptide wherein any amino acid of the chosen sequence is changed to a different amino acid, provided that no more than 10% of the amino acid residues in the sequence are so changed; and (f) the complement of any of said nucleic acid molecules.  
      In yet another specific embodiment, the invention includes an isolated nucleic acid molecule, wherein said nucleic acid molecule comprises a nucleotide sequence selected from the group consisting of: (a) the nucleotide sequence selected from the group consisting of SEQ ID NO: 2n−1, wherein n is an integer between 1 and 606; (b) a nucleotide sequence wherein one or more nucleotides in the nucleotide sequence selected from the group consisting of SEQ ID NO: 2n−1, wherein n is an integer between 1 and 606 is changed from that selected from the group consisting of the chosen sequence to a different nucleotide provided that no more than 15% of the nucleotides are so changed; (c) a nucleic acid fragment of the sequence selected from the group consisting of SEQ ID NO: 2n−1, wherein n is an integer between 1 and 606; and (d) a nucleic acid fragment wherein one or more nucleotides in the nucleotide sequence selected from the group consisting of SEQ ID NO: 2n−1, wherein n is an integer between 1 and 606 is changed from that selected from the group consisting of the chosen sequence to a different nucleotide provided that no more than 15% of the nucleotides are so changed.  
      NOVX Nucleic Acids and Polypeptides  
      One aspect of the invention pertains to isolated nucleic acid molecules that encode NOVX polypeptides or biologically active portions thereof. Also included in the invention are nucleic acid fragments sufficient for use as hybridization probes to identify NOVX-encoding nucleic acids (e.g., NOVX mRNAs) and fragments for use as PCk primers for the amplification and/or mutation of NOVX nucleic acid molecules. As used herein, the term “nucleic acid molecule” is intended to include DNA molecules (e.g., cDNA or genomic DNA), RNA molecules (e.g., mRNA), analogs of the DNA or RNA generated using nucleotide analogs, and derivatives, fragments and homologs thereof. The nucleic acid molecule may be single-stranded or double-stranded, but preferably is comprised double-stranded DNA.  
      A NOVX nucleic acid can encode a mature NOVX polypeptide. As used herein, a “mature” form of a polypeptide or protein disclosed in the present invention isthe product of a naturally occurring polypeptide or precursor form or proprotein. The naturally occurring polypeptide, precursor or proprotein includes, by way of nonlimiting example, the full-length gene product encoded by the corresponding gene. Alternatively, it may be defined as the polypeptide, precursor or proprotein encoded by an ORF described herein. The product “mature” form arises, by way of nonlimiting example, as a result of one or more naturally occurring processing steps that may take place within the cell (e.g., host cell) in which the gene product arises. Examples of such processing steps leading to a “mature” form of a polypeptide or protein include the cleavage of the N-terminal methionine residue encoded by the initiation codon of an ORF, or the proteolytic cleavage of a signal peptide or leader sequence. Thus a mature form arising from a precursor polypeptide or protein that has residues 1 to N, where residue 1 is the N-terminal methionine, would have residues 2 through N remaining after removal of the N-terminal methionine. Alternatively, a mature form arising from a precursor polypeptide or protein having residues 1 to N, in which an N-terminal signal sequence from residue 1 to residue M is cleaved, would have the residues from residue M+1 to residue N remaining. Further as used herein, a “mature” form of a polypeptide or protein may arise from a step of post-translational modification other than a proteolytic cleavage event. Such additional processes include, by way of non-limiting example, glycosylation, myristylation or phosphorylation. In general, a mature polypeptide or protein may result from the operation of only one of these processes, or a combination of any of them.  
      The term “probe”, as utilized herein, refers to nucleic acid sequences of variable length, preferably between at least about 10 nucleotides (nt), about 100 nt, or as many as approximately, e.g., 6,000 nt, depending upon the specific use. Probes are used in the detection of identical, similar, or complementary nucleic acid sequences. Longer length probes are generally obtained from a natural or recombinant source, are highly specific, and much slower to hybridize than shorter-length oligomer probes. Probes may be single-stranded or double-stranded and designed to have specificity in PCR, membrane-based hybridization technologies, or ELISA-like technologies.  
      The term “isolated” nucleic acid molecule, as used herein, is a nucleic acid that is separated from other nucleic acid molecules which are present in the natural source of the nucleic acid. Preferably, an “isolated” nucleic acid is free of sequences which naturally flank the nucleic acid (i.e., sequences located at the 5′- and 3′-termini of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived. For example, in various embodiments, the isolated NOVX nucleic acid molecules can contain less than about 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb or 0.1 kb of nucleotide sequences which naturally flank the nucleic acid molecule in genomic DNA of the cell/tissue from which the nuicleic acid is derived (e.g., brain, heart, liver, spleen, etc.). Moreover, an “isolated” nucleic acid molecule, such as a cDNA molecule, can be substantially free of other cellular material, or culture medium, or of chemical precursors or other chemicals.  
      A nucleic acid molecule of the invention, e.g., a nucleic acid molecule having the nucleotide sequence of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, or a complement of this nucleotide sequence, can be isolated using standard molecular biology techniques and the sequence information provided herein. Using all or a portion of the nucleic acid sequence of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, as a hybridization probe, NOVX molecules can be isolated using standard hybridization and cloning techniques (e.g., as described in Sambrook, et al., (eds.), MOLECULAR CLONING: A LABORATORY MANUAL 2 nd  Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989; and Ausubel, et al., (eds.), CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, John Wiley &amp; Sons, New York, N.Y., 1993.) A nucleic acid of the invention can be amplified using cDNA, mRNA or alternatively, genomicDNA, as a template with appropriate oligonucleotide primers according to standard PCR amplification techniques. The nucleic acid so amplified can be cloned into an appropriate vector and characterized by DNA sequence analysis. Furthermore, oligonucleotides corresponding to NOVX nucleotide sequences can be prepared by standard synthetic techniques, e.g., using an automated DNA synthesizer.  
      As used herein, the term “oligonucleotide” refers to a series of linked nucleotide residues. A short oligonucleotide sequence may be based on, or designed from, a genomic or cDNA sequence and is used to amplify, confirm, or reveal the presence of an identical, similar or complementary DNA or RNA in a particular cell or tissue. Oligonucleotides comprise a nucleic acid sequence having about 10 nt, 50 nt, or 100 nt in length, preferably about 15 nt to 30 nt in length. In one embodiment of the invention, an oligonucleotide comprising a nucleic acid molecule less than 100 nt in length would further comprise at least 6 contiguous nucleotides of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, or a complement thereof. Oligonucleotides may be chemically synthesized and may also be used as probes.  
      In another embodiment, an isolated nucleic acid molecule of the invention comprises a nucleic acid molecule that is a complement of the nucleotide sequence shown in SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, or a portion of this nucleotide sequence (e.g., a fragment that can be used as a probe or primer or a fragment encoding a biologically-active portion of a NOVX polypeptide). A nucleic acid molecule that is complementary to the nucleotide sequence of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, is one that is sufficiently complementary to the nucleotide sequence of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, that it can hydrogen bond with few or no mismatches to the nucleotide sequence shown in SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, thereby forming a stable duplex.  
      As used herein, the term “complementary” refers to Watson-Crick or Hoogsteen base pairing between nucleotides units of a nucleic acid molecule, and the term “binding” means the physical or chemical interaction between two polypeptides or compounds or associated polypeptides or compounds or combinations thereof. Binding includes ionic, non-ionic, van der Waals, hydrophobic interactions, and the like. A physical interaction can be either direct or indirect. Indirect interactions may be through or due to the effects of another polypeptide or compound. Direct binding refers to interactions that do not take place through, or due to, the effect of another polypeptide or compound, but instead are without other substantial chemical intermediates.  
      A “fragment” provided herein is defined as a sequence of at least 6 (contiguous) nucleic acids or at least 4 (contiguous) amino acids, a length sufficient to allow for specific hybridization in the case of nucleic acids or for specific recognition of an epitope in the case of amino acids, and is at most some portion less than a full length sequence. Fragments may be derived from any contiguous portion of a nucleic acid or amino acid sequence of choice.  
      A full-length NOVX clone is identified as containing an ATG translation start codon and an in-frame stop codon. Any disclosed NOVX nucleotide sequence lacking an ATG start codon therefore encodes a truncated C-terminal fragment of the respective NOVX polypeptide, and requires that the corresponding full-length cDNA extend in the 5′ direction of the disclosed sequence. Any disclosed NOVX nucleotide sequence lacking an in-frame stop codon similarly encodes a truncated N-terminal fragment of the respective NOVX polypeptide, and requires that the corresponding full-length cDNA extend in the 3′ direction of the disclosed sequence.  
      A “derivative” is a nucleic acid sequence or amino acid sequence formed from the native compounds either directly, by modification or partial substitution. An “analog” is a nucleic acid sequence or amino acid sequence that has a structure similar to, but not identical to, the native compound, e.g. they differs from it in respect to certain components or side chains. Analogs may be synthetic or derived from a different evolutionary origin and may have a similar or opposite metabolic activity compared to wild type. A “homolog” is a nucleic acid sequence or amino acid sequence of a particular gene that is derived from different species.  
      Derivatives and analogs may be full length or other than full length. Derivatives or analogs of the nucleic acids or proteins of the invention include, but are not limited to, molecules comprising regions that are substantially homologous to the nucleic acids or proteins of the invention, in various embodiments, by at least about 70%, 80%, or 95% identity (with a preferred identity of 80-95%) over a nucleic acid or amino acid sequence of identical size or when compared to an aligned sequence in which the alignment is done by a computer homology program known in the art, or whose encoding nucleic acid is capable of hybridizing to the complement of a sequence encoding the proteins under stringent, moderately stringent, or low stringent conditions. See e.g. Ausubel, et al., C UREN T P ROTOCOLS IN  M OLECULAR  B IOLOGY,  John Wiley &amp; Sons, New York, N.Y., 1993, and below.  
      A “homologous nucleic acid sequence” or “homologous amino acid sequence,” or variations thereof, refer to sequences characterized by a homology at the nucleotide level or amino acid level as discussed above. Homologous nucleotide sequences include those sequences coding for isoforms of NOVX polypeptides. Isoforms can be expressed in different tissues of the same organism as a result of, for example, alternative splicing of RNA. Alternatively, isoforms can be encoded by different genes. In the invention, homologous nucleotide sequences include nucleotide sequences encoding for a NOVX polypeptide of species other than humans, including, but not limited to: vertebrates, and thus can include, e.g., frog, mouse, rat, rabbit, dog, cat cow, horse, and other organisms. Homologous nucleotide sequences also include, but are not limited to, naturally occurring allelic variations and mutations of the nucleotide sequences set forth herein. A homologous nucleotide sequence does not, however, include the exact nucleotide sequence encoding human NOVX protein. Homologous nucleic acid sequences include those nucleic acid sequences that encode conservative amino acid substitutions (see below) in SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, as well as a polypeptide possessing NOVX biological activity. Various biological activities of the NOVX proteins are described below.  
      A NOVX polypeptide is encoded by the open reading frame (“ORF”) of a NOVX nucleic acid. An ORF corresponds to a nucleotide sequence that could potentially be translated into a polypeptide. A stretch of nucleic acids comprising an ORF is uninterrupted by a stop codon. An ORF that represents the coding sequence for a full protein begins with an ATG “start” codon and terminates with one of the three “stop” codons, namely, TAA, TAG, or TGA. For the purposes of this invention, an ORF may be any part of a coding sequence, with or without a start codon, a stop codon, or both. For an ORF to be considered as a good candidate for coding for a bonafide cellular protein, a minimum size requirement is often set, e.g., a stretch of DNA that would encode a protein of 50 amino acids or more.  
      The nucleotide sequences determined from the cloning of the human NOVX genes allows for the generation of probes and primers designed for use in identifying and/or cloning NOVX homologues in other cell types, e.g. from other tissues, as well as NOVX homologues from other vertebrates. The probe/primer typically comprises substantially purified oligonucleotide. The oligonucleotide typically comprises a region of nucleotide sequence that hybridizes under stringent conditions to at least about 12, 25, 50, 100, 150, 200, 250, 300, 350 or 400 consecutive sense strand nucleotide sequence of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606; or an anti-sense strand nucleotide sequence of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606; or of a naturally occurring mutant of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606.  
      Probes based on the human NOVX nucleotide sequences can be used to detect transcripts or genomic sequences encoding the same or homologous proteins. In various embodiments, the probe has a detectable label attached, e.g. the label can be a radioisotope, a fluorescent compound, an enzyme, or an enzyme co-factor. Such probes can be used as a part of a diagnostic test kit for identifying cells or tissues which mis-express a NOVX protein, such as by measuring a level of a NOVX-encoding nucleic acid in a sample of cells from a subject e.g., detecting NOVX mRNA levels or determining whether a genomic NOVX gene has been mutated or deleted. “A polypeptide having a biologically-active portion of a NOVX polypeptide” refers to polypeptides exhibiting activity similar, but not necessarily identical to, an activity of a polypeptide of the invention, including mature forms, as measured in a particular biological assay, with or without dose dependency. A nucleic acid fragment encoding a “biologically-active portion of NOVX” can be prepared by isolating a portion of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, that encodes a polypeptide having a NOVX biological activity (the biological activities of the NOVX proteins are described below), expressing the encoded portion of NOVX protein (e.g., by recombinant expression in vitro) and assessing the activity of the encoded portion of NOVX.  
      NOVX Single Nucleotide Polymorphisms  
      Variant sequences are also included in this application. A variant sequence can include a single nucleotide polymorphism (SNP). A SNP can, in some instances, be referred to as a “cSNP” to denote that the nucleotide sequence containing the SNP originates as a cDNA. A SNP can arise in several ways. For example, a SNP may be due to a substitution of one nucleotide for another at the polymorphic site. Such a substitution can be either a transition or a transversion. A SNP can also arise from a deletion of a nucleotide or an insertion of a nucleotide, relative to a reference allele. In this case, the polymorphic site is a site at which one allele bears a gap with respect to a particular nucleotide in another allele. SNPs occurring within genes may result in an alteration of the amino acid encoded by the gene at the position of the SNP. Intragenic SNPs may also be silent, when a codon including a SNP encodes the same amino acid as a result of the redundancy of the genetic code. SNPs occurring outside the region of a gene, or in an intron within a gene, do not result in changes in any amino acid sequence of a protein but may result in altered regulation of the expression pattern. Examples include alteration in temporal expression, physiological response regulation, cell type expression regulation, intensity of expression, and stability of transcribed message.  
      SeqCalling assemblies produced by the exon linking process were selected and extended using the following criteria. Genomic clones having regions with 98% identity to all or part of the initial or extended sequence were identified by BLASTN searches using the relevant sequence to query human genomic databases. The genomic clones that resulted were selected for further analysis because this identity indicates that these clones contain the genomic locus for these SeqCalling assemblies. These sequences were analyzed for putative coding regions as well as for similarity to the known DNA and protein sequences. Programs used for these analyses include Grail, Genscan, BLAST, HMMER, FASTA, Hybrid and other relevant programs.  
      Some additional genomic regions may have also been identified because selected SeqCalling assemblies map to those regions. Such SeqCalling sequences may have overlapped with regions defined by homology or exon prediction. They may also be included because the location of the fragment was in the vicinity of genomic regions identified by similarity or exon prediction that had been included in the original predicted sequence. The sequence so identified was manually assembled and then may have been extended using one or more additional sequences taken from CuraGen Corporation&#39;s human SeqCalling database. SeqCalling fragments suitable for inclusion were identified by the CuraTools™ program SeqExtend or by identifying SeqCalling fragments mapping to the appropriate regions of the genomic clones analyzed.  
      The regions defined by the procedures described above were then manually integrated and corrected for apparent inconsistencies that may have arisen, for example, from miscalled bases in the original fragments or from discrepancies between predicted exon junctions, EST locations and regions of sequence similarity, to derive the final sequence disclosed herein. When necessary, the process to identify and analyze SeqCalling assemblies and genomic clones was reiterated to derive the full length sequence (Alderbom et al., Determination of Single Nucleotide Polymorphisms by Real-time Pyrophosphate DNA Sequencing. Genome Research. 10 (8) 1249-1265, 2000).  
      Variants are reported individually but any combination of all or a select subset of variants are also included as contemplated NOVX embodiments of the invention.  
      NOVX Nucleic Acid and Polypeptide Variants  
      The invention further encompasses nucleic acid molecules that differ from the nucleotide sequences of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, due to degeneracy of the genetic code and thus encode the same NOVX proteins as that encoded by the nucleotide sequences of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606. In another embodiment, an isolated nucleic acid molecule of the invention has a nucleotide sequence encoding a protein having an amino acid sequence of SEQ ID NO:2n, wherein n is an integer between 1 and 606.  
      In addition to the human NOVX nucleotide sequences of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, it will be appreciated by those skilled in the art that DNA sequence polymorphisms that lead to changes in the amino acid sequences of the NOVX polypeptides may exist within a population (e.g., the human population). Such genetic polymorphism in the NOVX genes may exist among individuals within a population due to natural allelic variation. As used herein, the terms “gene” and “recombinant gene” refer to nucleic acid molecules comprising an open reading frame (ORF) encoding a NOVX protein, preferably a vertebrate NOVX protein. Such natural allelic variations can typically result in 1-5% variance in the nucleotide sequence of the NOVX genes. Any and all such nucleotide variations and resulting amino acid polymorphisms in the NOVX polypeptides, which are the result of natural allelic variation and that do not alter the functional activity of the NOVX polypeptides, are intended to be within the scope of the invention.  
      Moreover, nucleic acid molecules encoding NOVX proteins from other species, and thus that have a nucleotide sequence that differs from a human SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, are intended to be within the scope of the invention. Nucleic acid molecules corresponding to natural allelic variants and homologues of the NOVX cDNAs of the invention can be isolated based on their homology to the human NOVX nucleic acids disclosed herein using the human cDNAs, or a portion thereof, as a hybridization probe according to standard hybridization techniques under stringent hybridization conditions.  
      Accordingly, in another embodiment, an isolated nucleic acid molecule of the invention is at least 6 nucleotides in length and hybridizes under stringent conditions to the nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606. In another embodiment, the nucleic acid is at least 10, 25, 50, 100, 250, 500, 750, 1000, 1500, or 2000 or more nucleotides in length. In yet another embodiment, an isolated nucleic acid molecule of the invention hybridizes to the coding region. As used herein, the term “hybridizes under stringent conditions” is intended to describe conditions for hybridization and washing under which nucleotide sequences at least about 65% homologous to each other typically remain hybridized to each other.  
      Homologs (i.e., nucleic acids encoding NOVX proteins derived from species other than human) or other related sequences (e.g., paralogs) can be obtained by low, moderate or high stringency hybridization with all or a portion of the particular human sequence as a probe using methods well known in the art for nucleic acid hybridization and cloning.  
      As used herein, the phrase “stringent hybridization conditions” refers to conditions under which a probe, primer or oligonucleotide will hybridize to its target sequence, but to no other sequences. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridize specifically at higher temperatures than shorter sequences. Generally, stringent conditions are selected to be about 5 ° C lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength and pH. The Tm is the temperature (under defined ionic strength, pH and nucleic acid concentration) at which 50% of the probes complementary to the target sequence hybridize to the target sequence at equilibrium. Since the target sequences are generally present at excess, at Tm, 50% of the probes are occupied at equilibrium. Typically, stringent conditions will be those in which the salt concentration is less than about 1.0 M sodium ion, typically about 0.01 to 1.0 M sodium ion (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30° C. for short probes, primers or oligonucleotides (e.g., 10 nt to 50 nt) and at least about 60° C. for longer probes, primers and oligonucleotides. Stringent conditions may also be achieved with the addition of destabilizing agents, such as formamide.  
      Stringent conditions are known to those skilled in the art and can be found in Ausubel, et al., (eds.), C URRENT  P ROTOCOLS IN  M OLECULAR  B IOLOGY,  John Wiley &amp; Sons, N.Y. (1989), 6.3.1-6.3.6. Preferably, the conditions are such that sequences at least about 65%, 70%, 75%, 85%, 90%, 95%, 98%, or 99% homologous to each other typically remain hybridized to each other. A non-limiting example of stringent hybridization conditions are hybridization in a high salt buffer comprising 6×SSC, 50 mM Tris-HCl (pH 7.5), 1 mM EDTA, 0.02% PVP, 0.02% Ficoll, 0.02% BSA, and 500 mg/ml denatured salmon sperm DNA at 65° C., followed by one or more washes in 0.2×SSC, 0.01% BSA at 50° C. An isolated nucleic acid molecule of the invention that hybridizes under stringent conditions to a sequence of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, corresponds to a naturally-occurring nucleic acid molecule. As used herein, a “naturally-occurring” nucleic acid molecule refers to an RNA or DNA molecule having a nucleotide sequence that occurs in nature (e.g., encodes a natural protein).  
      In a second embodiment, a nucleic acid sequence that is hybridizable to the nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, or fragments, analogs or derivatives thereof, under conditions of moderate stringency is provided. A non-limiting example of moderate stringency hybridization conditions are hybridization in 6×SSC, 5×Reinhardt&#39;s solution, 0.5% SDS and 100 mg/ml denatured salmon sperm DNA at 55° C., followed by one or more washes in 1×SSC, 0.1% SDS at 37° C. Other conditions of moderate stringency that may be used are well-known within the art. See, e.g., Ausubel. et al. (eds.), 1993, C URRENT  P ROTOCOLS IN  M OLECULAR  B IOLOGY,  John Wiley &amp; Sons, NY, and Krieger, 1990; G ENE  T RANSFER AND  E XPRESSION,  A L ABORATORY  M ANUAL,  Stockton Press, N.Y.  
      In a third embodiment, a nucleic acid that is hybridizable to the nucleic acid molecule comprising the nucleotide sequences of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, or fragments, analogs or derivatives thereof, under conditions of low stringency, is provided. A non-limiting example of low stringency hybridization conditions are hybridization in 35% formamide, 5×SSC, 50 mM Tris-HCl (pH 7.5), 5 mM EDTA, 0.02% PVP, 0.02% Ficoll, 0.2% BSA, 100 mg/ml denatured salmon sperm DNA, 10% (wt/vol) dextran sulfate at 40° C., followed by one or more washes in 2×SSC, 25 mM Tris-HCl (pH 7.4), 5 mM EDTA, and 0.1% SDS at 50° C. Other conditions of low stringency that may be used are well known in the art (e.g., as employed for cross-species hybridizations). See, e.g., Ausubel, et al. (eds.), 1993, C URRENT  P ROTOCOLS IN  M OLECULAR  B IOLOGY,  John Wiley &amp; Sons, NY, and Kriegler, 1990, G ENE  T RANSFER AND  E XPRESSION,  A L ABORATORY  M ANUAL,  Stockton Press, N.Y.; Shilo and Weinberg, 1981.  Proc Natl Acad Sci USA  78: 6789-6792.  
      Conservative Mutations  
      In addition to naturally-occurring allelic variants of NOVX sequences that may exist in the population, the skilled artisan will further appreciate that changes can be introduced by mutation into the nucleotide sequences of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, thereby leading to changes in the amino acid sequences of the encoded NOVX protein, without altering the functional ability of that NOVX protein. For example, nucleotide substitutions leading to amino acid substitutions at “non-essential” amino acid residues can be made in the sequence of SEQ ID NO:2n, wherein n is an integer between 1 and 606. A “non-essential” amino acid residue is a residue that can be altered from the wild-type sequences of the NOVX proteins without altering their biological activity, whereas an “essential” amino acid residue is required for such biological activity. For example, amino acid residues that are conserved among the NOVX proteins of the invention are predicted to be particularly non-amenable to alteration. Amino acids for which conservative substitutions can be made are well-known within the art.  
      Another aspect of the invention pertains to nucleic acid molecules encoding NOVX proteins that contain changes in amino acid residues that are not essential for activity. Such NOVX proteins differ in amino acid sequence from SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, yet retain biological activity. In one embodiment, the isolated nucleic acid molecule comprises a nucleotide sequence encoding a protein, wherein the protein comprises an amino acid sequence at least about 40% homologous to the amino acid sequences of SEQ ID NO:2n, wherein n is an integer between 1 and 606. Preferably, the protein encoded by the nucleic acid molecule is at least about 60% homologous to SEQ ID NO:2n, wherein n is an integer between 1 and 606; more preferably at least about 70% homologous to SEQ ID NO:2n, wherein n is an integer between 1 and 606; still more preferably at least about 80% homologous to SEQ ID NO:2n, wherein n is an integer between 1 and 606; even more preferably at least about 90% homologous to SEQ ID NO:2n, wherein n is an integer between 1 and 606; and most preferably at least about 95% homologous to SEQ ID NO:2n, wherein n is an integer between 1 and 606.  
      An isolated nucleic acid molecule encoding a NOVX protein homologous to the protein of SEQ ID NO:2n, wherein n is an integer between 1 and 606, can be created by introducing one or more nucleotide substitutions, additions or deletions into the nucleotide sequence of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, such that one or more amino acid substitutions, additions or deletions are introduced into the encoded protein.  
      Mutations can be introduced any one of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, by standard techniques, such as site-directed mutagenesis and PCR-mediated mutagenesis. Preferably, conservative amino acid substitutions are made at one or more predicted, non-essential amino acid residues. A “conservative amino acid substitution” is one in which the amino acid residue is replaced with an amino acid residue having a similar side chain. Families of amino acid residues having similar side chains have been defined within the art. These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), beta-branched side chains (e.g., threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine). Thus, a predicted non-essential amino acid residue in the NOVX protein is replaced with another amino acid residue from the same side chain family. Alternatively, in another embodiment, mutations can be introduced randomly along all or part of a NOVX coding sequence, such as by saturation mutagenesis, and the resultant mutants can be screened for NOVX biological activity to identify mutants that retain activity. Following mutagenesis of a nucleic acid of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, the encoded protein can be expressed by any recombinant technology known in the art and the activity of the protein can be determined.  
      The relatedness of amino acid families may also be determined based on side chain interactions. Substituted amino acids may be fully conserved “strong” residues or fully conserved “weak” residues. The “strong” group of conserved amino acid residues may be any one of the following groups: STA, NEQK, NHQK, NDEQ, QHRK, MILV, MILF, HY, FYW, wherein the single letter amino acid codes are grouped by those amino acids that may be substituted for each other. Likewise, the “weak” group of conserved residues may be any one of the following: CSA, ATV, SAG, STNK, STPA, SGND, SNDEQK, NDEQHK, NEQHRK, HFY, wherein the letters within each group represent the single letter amino acid code.  
      In one embodiment, a mutant NOVX protein can be assayed for (i) the ability to form protein:protein interactions with other NOVX proteins, other cell-surface proteins, or biologically-active portions thereof, (ii) complex formation between a mutant NOVX protein and a NOVX ligand; or (iii) the ability of a mutant NOVX protein to bind to an intracellular target protein or biologically-active portion thereof; (e.g. avidin proteins).  
      In yet another embodiment, a mutant NOVX protein can be assayed for the ability to regulate a specific biological function (e.g., regulation of insulin release).  
      Interfering RNA  
      In one aspect of the invention, NOVX gene expression can be attenuated by RNA interference. One approach well-known in the art is short interfering RNA (siRNA) mediated gene silencing where expression products of a NOVX gene are targeted by specific double stranded NOVX derived siRNA nucleotide sequences that are complementary to at least a 19-25 nt long segment of the NOVX gene transcript, including the 5′ untranslated (UT) region, the ORF, or the 3′ UT region. See, e.g., PCT applications WO00/44895, WO99/32619, WO01/75164, WO01/92513, WO 01/29058, WO01/89304, WO02/16620, and WO02/29858, each incorporated by reference herein in their entirety. Targeted genes can be a NOVX gene, or an upstream or downstream modulator of the NOVX gene. Nonlimiting examples of upstream or downstream modulators of a NOVX gene include, e.g., a transcription factor that binds the NOVX gene promoter, a kinase or phosphatase that interacts with a NOVX polypeptide, and polypeptides involved in a NOVX regulatory pathway.  
      According to the methods of the present invention, NOVX gene expression is silenced using short interfering RNA. A NOVX polynucleotide according to the invention includes a siRNA polynucleotide. Such a NOVX siRNA can be obtained using a NOVX polynucleotide sequence, for example, by processing the NOVX ribopolynucleotide sequence in a cell-free system, such as but not limited to a Drosophila extract, or by transcription of recombinant double stranded NOVX RNA or by chemical synthesis of nucleotide sequences homologous to a NOVX sequence. See, e.g., Tuschl, Zamore, Lehmann, Bartel and Sharp (1999), Genes &amp; Dev. 13: 3191-3197, incorporated herein by reference in its entirety. When synthesized, a typical 0.2 micromolar-scale RNA synthesis provides about 1 milligram of siRNA, which is sufficient for 1000 transfection experiments using a 24-well tissue culture plate format.  
      The most efficient silencing is generally observed with siRNA duplexes composed of a 21-nt sense strand and a 21-nt antisense strand, paired in a manner to have a 2-nt 3′ overhang. The sequence of the 2-nt 3′ overhang makes an additional small contribution to the specificity of siRNA target recognition. The contribution to specificity is localized to the unpaired nucleotide adjacent to the first paired bases. In one embodiment, the nucleotides in the 3′ overhang are ribonucleotides. In an alternative embodiment, the nucleotides in the 3′ overhang are deoxyribonucleotides. Using 2′-deoxyribonucleotides in the 3′ overhangs is as efficient as using ribonucleotides, but deoxyribonucleotides are often cheaper to synthesize and are most likely more nuclease resistant.  
      A contemplated recombinant expression vector of the invention comprises a NOVX DNA molecule cloned into an expression vector comprising operatively-linked regulatory sequences flanking the NOVX sequence in a manner that allows for expression (by transcription of the DNA molecule) of both strands. An RNA molecule that is antisense to NOVX mRNA is transcribed by a first promoter (e.g., a promoter sequence 3′ of the cloned DNA) and an RNA molecule that is the sense strand for the NOVX mRNA is transcribed by a second promoter (e.g., a promoter sequence 5′ of the cloned DNA). The sense and antisense strands may hybridize in vivo to generate siRNA constructs for silencing of the NOVX gene. Alternatively, two constructs can be utilized to create the sense and anti-sense strands of a siRNA construct. Finally, cloned DNA can encode a construct having secondary structure, wherein a single transcript has both the sense and complementary antisense sequences from the target gene or genes. In an example of this embodiment, a hairpin RNAi product is homologous to all or a portion of the target gene. In another example, a hairpin RNAi product is a siRNA. The regulatory sequences flanking the NOVX sequence may be identical or may be different, such that their expression may be modulated independently, or in a temporal or spatial manner.  
      In a specific embodiment, siRNAs are transcribed intracellularly by cloning the NOVX gene templates into a vector containing, e.g., a RNA pol III transcription unit from the smaller nuclear RNA (snRNA) U6 or the human RNase P RNA H1. One example of a vector system is the GeneSuppressor™ RNA Interference kit (commercially available from Imgenex). The U6 and H1 promoters are members of the type III class of Pol III promoters. The +1 nucleotide of the U6-like promoters is always guanosine, whereas the +1 for H1 promoters is adenosine. The termination signal for these promoters is defined by five consecutive thymidines. The transcript is typically cleaved after the second uridine. Cleavage at this position generates a 3′ UU overhang in the expressed siRNA, which is similar to the 3′ overhangs of synthetic siRNAs. Any sequence less than 400 nucleotides in length can be transcribed by these promoter, therefore they are ideally suited for the expression of around 21-nucleotide siRNAs in, e.g., an approximately 50-nucleotide RNA stem-loop transcript.  
      A siRNA vector appears to have an advantage over synthetic siRNAs where long term knock-down of expression is desired. Cells transfected with a siRNA expression vector would experience steady, long-term mRNA inhibition. In contrast, cells transfected with exogenous synthetic siRNAs typically recover from mRNA suppression within seven days or ten rounds of cell division. The long-term gene silencing ability of siRNA expression vectors may provide for applications in gene therapy.  
      In general, siRNAs are chopped from longer dsRNA by an ATP-dependent ribonuclease called DICER. DICER is a member of the RNase III family of double-stranded RNA-specific endonucleases. The siRNAs assemble with cellular proteins into an endonuclease complex. In vitro studies in  Drosophila  suggest that the siRNAs/protein complex (siRNP) is then transferred to a second enzyme complex, called an RNA-induced silencing complex (RISC), which contains an endoribonuclease that is distinct from DICER. RISC uses the sequence encoded by the antisense siRNA strand to find and destroy mRNAs of complementary sequence. The siRNA thus acts as a guide, restricting the ribonuclease to cleave only mRNAs complementary to one of the two siRNA strands.  
      A NOVX mRNA region to be targeted by siRNA is generally selected from a desired NOVX sequence beginning 50 to 100 nt downstream of the start codon. Alternatively, 5′ or 3′ UTRs and regions nearby the start codon can be used but are generally avoided, as these may be richer in regulatory protein binding sites. UTR-binding proteins andlor translation initiation complexes may interfere with binding of the siRNP or RISC endonuclease complex. An initial BLAST homology search for the selected siRNA sequence is done against an available nucleotide sequence library to ensure that only one gene is targeted. Specificity of target recognition by siRNA duplexes indicate that a single point mutation located in the paired region of an siRNA duplex is sufficient to abolish target mRNA degradation. See, Elbashir et al. 2001 EMBO J. 20(23):6877-88. Hence, consideration should be taken to accommodate SNPs, polymorphisms, allelic variants or species-specific variations when targeting a desired gene.  
      In one embodiment, a complete NOVX siRNA experiment includes the proper negative control. A negative control siRNA generally has the same nucleotide composition as the NOVX siRNA but lack significant sequence homology to the genome. Typically, one would scramble the nucleotide sequence of the NOVX siRNA and do a homology search to make sure it lacks homology to any other gene.  
      Two independent NOVX siRNA duplexes can be used to knock-down a target NOVX gene. This helps to control for specificity of the silencing effect. In addition, expression of two independent genes can be simultaneously knocked down by using equal concentrations of different NOVX siRNA duplexes, e.g., a NOVX siRNA and an siRNA for a regulator of a NOVX gene or polypeptide. Availability of siRNA-associating proteins is believed to be more limiting than target mRNA accessibility.  
      A targeted NOVX region is typically a sequence of two adenines (AA) and two thymidines (TT) divided by a spacer region of nineteen (N19) residues (e.g., AA(N19)TT). A desirable spacer region has a G/C-content of approximately 30% to 70%, and more preferably of about 50%. If the sequence AA(N19)TT is not present in the target sequence, an alternative target region would be AA(N21). The sequence of the NOVX sense siRNA corresponds to (N19)TT or N21, respectively. In the latter case, conversion of the 3′ end of the sense siRNA to TT can be performed if such a sequence does not naturally occur in the NOVX polynucleotide. The rationale for this sequence conversion is to generate a symmetric duplex with respect to the sequence composition of the sense and antisense 3′ overhangs. Symmetric 3′ overhangs may help to ensure that the siRNPs are formed with approximately equal ratios of sense and antisense target RNA-cleaving siRNPs. See, e.g., Elbashir, Lendeckel and Tuschl (2001). Genes &amp; Dev. 15: 188-200, incorporated by reference herein in its entirely. The modification of the overhang of the sense sequence of the siRNA duplex is not expected to affect targeted mRNA recognition, as the antisense siRNA strand guides target recognition.  
      Alternatively, if the NOVX target mRNA does not contain a suitable AA(N21) sequence, one may search for the sequence NA(N21). Further, the sequence of the sense strand and antisense strand may still be synthesized as 5′ (N19)TT, as it is believed that the sequence of the 3′-most nucleotide of the antisense siRNA does not contribute to specificity. Unlike antisense or ribozyme technology, the secondary structure of the target rnRNA does not appear to have a strong effect on silencing. See, Harborth, et al. (2001) J. Cell Science 114: 4557-4565, incorporated by reference in its entirety.  
      Transfection of NOVX siRNA duplexes can be achieved using standard nucleic acid transfection methods, for example, OLIGOFECTAMINE Reagent (commercially available from Invitrogen). An assay for NOVX gene silencing is generally performed approximately 2 days after transfection. No NOVX gene silencing has been observed in the absence of transfection reagent, allowing for a comparative analysis of the wild-type and silenced NOVX phenotypes. In a specific embodiment, for one well of a 24-well plate, approximately 0.84 μg of the siRNA duplex is generally sufficient. Cells are typically seeded the previous day, and are transfected at about 50% confluence. The choice of cell culture media and conditions are routine to those of skill in the art, and will vary with the choice of cell type. The efficiency of transfection may depend on the cell type, but also on the passage number and the confluency of the cells. The time and the manner of formation of siRNA-liposome complexes (e.g. inversion versus vortexing) are also critical. Low transfection efficiencies are the most frequent cause of unsuccessful NOVX silencing. The efficiency of transfection needs to be carefully examined for each new cell line to be used. Preferred cell are derived from a mammal, more preferably from a rodent such as a rat or mouse, and most preferably from a human. Where used for therapeutic treatment, the cells are preferentially autologous, although non-autologous cell sources are also contemplated as within the scope of the present invention.  
      For a control experiment, transfection of 0.84 μg single-stranded sense NOVX siRNA will have no effect on NOVX silencing, and 0.84 μg antisense siRNA has a weak silencing effect when compared to 0.84 μg of duplex siRNAs. Control experiments again allow for a comparative analysis of the wild-type and silenced NOVX phenotypes. To control for transfection efficiency, targeting of common proteins is typically performed, for example targeting of lamin A/C or transfection of a CMV-driven EGFP-expression plasmid (e.g. commercially available from Clontech). In the above example, a determination of the fraction of lamin A/C knockdown in cells is determined the next day by such techniques as immunofluorescence, Western blot, Northern blot or other similar assays for protein expression or gene expression. Lamin A/C monoclonal antibodies may be obtained from Santa Cruz Biotechnology.  
      Depending on the abundance and the half life (or turnover) of the targeted NOVX polynucleotide in a cell, a knock-down phenotype may become apparent after 1 to 3 days, or even later. In cases where no NOVX knock-down phenotype is observed, depletion of the NOVX polynucleotide may be observed by immunofluorescence or Western blotting. If the NOVX polynucleotide is still abundant after 3 days, cells need to be split and transferred to a fresh 24-well plate for re-transfection. If no knock-down of the targeted protein is observed, it may be desirable to analyze whether the target mRNA (NOVX or a NOVX upstream or downstream gene) was effectively destroyed by the transfected siRNA duplex. Two days after transfection, total RNA is prepared, reverse transcribed using a target-specific primer, and PCR-amplified with a primer pair covering at least one exon-exon junction in order to control for amplification of pre-mRNAs. RT/PCR of a non-targeted mRNA is also needed as control. Effective depletion of the mRNA yet undetectable reduction of target protein may indicate that a large reservoir of stable NOVX protein may exist in the cell. Multiple transfection in sufficiently long intervals may be necessary until the target protein is finally depleted to a point where a phenotype may become apparent. If multiple transfection steps are required, cells are split 2 to 3 days after transfection. The cells may be transfected immediately after splitting.  
      An inventive therapeutic method of the invention contemplates administering a NOVX siRNA construct as therapy to compensate for increased or aberrant NOVX expression or activity. The NOVX ribopolynucleotide is obtained and processed into siRNA fragments, or a NOVX siRNA is synthesized, as described above. The NOVX siRNA is administered to cells or tissues using known nucleic acid transfection techniques, as described above. A NOVX siRNA specific for a NOVX gene will decrease or knockdown NOVX transcription products, which will lead to reduced NOVX polypeptide production, resulting in reduced NOVX polypeptide activity in the cells or tissues.  
      The present invention also encompasses a method of treating a disease or condition associated with the presence of a NOVX protein in an individual comprising administering to the individual an RNAi construct that targets the mRNA of the protein (the mRNA that encodes the protein) for degradation. A specific RNAi construct includes a siRNA or a double stranded gene transcript that is processed into siRNAs. Upon treatment, the target protein is not produced or is not produced to the extent it would be in the absence of the treatment.  
      Where the NOVX gene function is not correlated with a known phenotype, a control sample of cells or tissues from healthy individuals provides a reference standard for determining NOVX expression levels. Expression levels are detected using the assays described, e.g., RT-PCR, Northern blotting, Western blotting, ELISA, and the like. A subject sample of cells or tissues is taken from a mammal, preferably a human subject, suffering from a disease state. The NOVX ribopolynucleotide is used to produce siRNA constructs, that are specific for the NOVX gene product. These cells or tissues are treated by administering NOVX siRNA&#39;s to the cells or tissues by methods described for the transfection of nucleic acids into a cell or tissue, and a change in NOVX polypeptide or polynucleotide expression is observed in the subject sample relative to the control sample, using the assays described. This NOVX gene knockdown approach provides a rapid method for determination of a NOVX minus (NOVX − ) phenotype in the treated subject sample. The NOVX- phenotype observed in the treated subject sample thus serves as a marker for monitoring the course of a disease state during treatment.  
      In specific embodiments, a NOVX siRNA is used in therapy. Methods for the generation and use of a NOVX siRNA are known to those skilled in the art. Example techniques are provided below.  
      Production of RNAs  
      Sense RNA (ssRNA) and antisense RNA (asRNA) of NOVX are produced using known methods such as transcription in RNA expression vectors. In the initial experiments, the sense and antisense RNA are about 500 bases in length each. The produced ssRNA and asRNA (0.5 μM) in 10 mM Tris-HCl (pH 7.5) with 20 mM NaCl were heated to 95° C. for 1 min then cooled and annealed at room temperature for 12 to 16 h. The RNAs are precipitated and resuspended in lysis buffer (below). To monitor annealing, RNAs are electrophoresed in a 2% agarose gel in TBE buffer and stained with ethidium bromide. See, e.g., Sambrook et al., Molecular Cloning. Cold Spring Harbor Laboratory Press, Plainview, N.Y. (1989).  
      Lysate Preparation  
      Untreated rabbit reticulocyte lysate (Ambion) are assembled according to the manufacturer&#39;s directions. dsRNA is incubated in the lysate at 30° C. for 10 min prior to the addition of mRNAs. Then NOVX mRNAs are added and the incubation continued for an additional 60 min. The molar ratio of double stranded RNA and MrRNA is about 200:1. The NOVX mRNA is radiolabeled (using known techniques) and its stability is monitored by gel electrophoresis.  
      In a parallel experiment made with the same conditions, the double stranded RNA is internally radiolabeled with a  32 P-ATP. Reactions are stopped by the addition of 2× proteinase K buffer and deproteinized as described previously (Tuschl et al., Genes Dev., 13:3191-3197 (1999)). Products are analyzed by electrophoresis in 15% or 18% polyacrylamide sequencing gels using appropriateRNA standards. By monitoring the gels for radioactivity, the natural production of 10 to 25 nt RNAs from the double stranded RNA can be determined.  
      The band of double stranded RNA, about 21-23 bps, is eluded. The efficacy of these 21-23 mers for suppressing NOVX transcription is assayed in vitro using the same rabbit reticulocyte assay described above using 50 nanomolar of double stranded 21-23 mer for each assay. The sequence of these 21-23 mers is then determined using standard nucleic acid sequencing techniques.  
      RNA Preparation 21 nt RNAs, based on the sequence determined above, are chemically synthesized using Expedite RNA phosphoramidites and thymidine phosphoramidite (Proligo, Germany). Synthetic oligonucleotides are deprotected and gel-purified (Elbashir, Lendeckel, &amp; Tuschl, Genes &amp; Dev. 15, 188-200 (2001)), followed by Sep-Pak C18 cartridge (Waters, Milford, Mass., USA) purification (Tuschl, et al., Biochemistry, 32:11658-11668 (1993)).  
      These RNAs (20 μM) single strands are incubated in annealing buffer (100 mM potassium acetate, 30 mM HEPES-KOH at pH 7.4, 2 mM magnesium acetate) for 1 min at 90° C. followed by 1 h at 37° C.  
      Cell Culture  
      A cell culture known in the art to regularly express NOVX is propagated using standard conditions. 24 hours before transfection, at approx. 80% confluency, the cells are trypsinized and diluted 1:5 with fresh medium without antibiotics (1-3×105 cells/ml) and transferred to 24-well plates (500 ml/well). Transfection is performed using a commercially available lipofection kit and NOVX expression is monitored using standard techniques with positive and negative control. A positive control is cells that naturally express NOVX while a negative control is cells that do not express NOVX. Base-paired 21 and 22 nt siRNAs with overhanging 3′ ends mediate efficient sequence-specific mRNA degradation in lysates and in cell culture. Different concentrations of siRNAs are used. An efficient concentration for suppression in vitro in mamrnmalian culture is between 25 nM to 100 nM final concentration. This indicates that siRNAs are effective at concentrations that are several orders of magnitude below the concentrations applied in conventional antisense or ribozyme gene targeting experiments.  
      The above method provides a way both for the deduction of NOVX siRNA sequence and the use of such siRNA for in vitro suppression. In vivo suppression may be performed using the same siRNA using well known in vivo transfection or gene therapy transfection techniques.  
      Antisense Nucleic Acids  
      Another aspect of the invention pertains to isolated antisense nucleic acid molecules that are hybridizable to or complementary to the nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, or fragments, analogs or derivatives thereof. An “antisense” nucleic acid comprises a nucleotide sequence that is complementary to a “sense” nucleic acid encoding a protein (e.g., complementary to the coding strand of a double-stranded cDNA molecule or complementary to an mRNA sequence). In specific aspects, antisense nucleic acid molecules are provided that comprise a sequence complementary to at least about 10, 25, 50, 100, 250 or 500 nucleotides or an entire NOVX coding strand, or to only a portion thereof. Nucleic acid molecules encoding fragments, homologs, derivatives and analogs of a NOVX protein of SEQ ID NO:2n, wherein n is an integer between 1 and 606, or antisense nucleic acids complementary to a NOVX nucleic acid sequence of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, are additionally provided.  
      In one embodiment, an antisense nucleic acid molecule is antisense to a “coding region” of the coding strand of a nucleotide sequence encoding a NOVX protein. The term “coding region” refers to the region of the nucleotide sequence comprising codons which are translated into amino acid residues. In another embodiment, the antisense nucleic acid molecule is antisense to a “noncoding region” of the coding strand of a nucleotide sequence encoding the NOVX protein. The term “noncoding region” refers to 5′ and 3′ sequences which flank the coding region that are not translated into amino acids (i.e., also referred to as 5′ and 3′ untranslated regions).  
      Given the coding strand sequences encoding the NOVX protein disclosed herein, antisense nucleic acids of the invention can be designed according to the rules of Watson and Crick or Hoogsteen base pairing. The antisense nucleic acid molecule can be complementary to the entire coding region of NOVX mRNA, but more preferably is an oligonucleotide that is antisense to only a portion of the coding or noncoding region of NOVX mRNA. For example, the antisense oligonucleotide can be complementary to the region surrounding the translation start site of NOVX mRNA. An antisense oligonucleotide can be, for example, about 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 nucleotides in length. An antisense nucleic acid of the invention can be constructed using chemical synthesis or enzymatic ligation reactions using procedures known in the art. For example, an antisense nucleic acid (e.g., an antisense oligonucleotide) can be chemically synthesized using naturally-occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids (e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used).  
      Examples of modified nucleotides that can be used to generate the antisense nucleic acid include: 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytosine, 5-carboxymethylaminomethyl-2-thiouridine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 5-methoxyuracil, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, 2-thiouracil, 4-thiouracil, beta-D-mannosylqueosine, 5′-methoxycarboxymethyluracil, 2-methylthio-N6-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl) uracil, (acp3)w, and 2,6-diaminopurine. Alternatively, the antisense nucleic acid can be produced biologically using an expression vector into which a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following subsection).  
      The antisense nucleic acid molecules of the invention are typically administered to a subject or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encodinga NOVX protein to thereby inhibit expression of the protein (e.g., by inhibiting transcription and/or translation). The hybridization can be by conventional nucleotide complementarity to form a stable duplex, or, for example, in the case of an antisense nucleic acid molecule that binds to DNA duplexes, through specific interactions in the major groove of the double helix. An example of a route of administration of antisense nucleic acid molecules of the invention includes direct injection at a tissue site. Alternatively, antisense nucleic acid molecules can be modified to target selected cells and then administered systemically. For example, for systemic administration, antisense molecules can be modified such that they specifically bind to receptors or antigens expressed on a selected cell surface (e.g., by linking the antisense nucleic acid molecules to peptides or antibodies that bind to cell surface receptors or antigens). The antisense nucleic acid molecules can also be delivered to cells using the vectors described herein. To achieve sufficient nucleic acid molecules, vector constructs in which the antisense nucleic acid molecule is placed under the control of a strong pol II or pol III promoter are preferred.  
      In yet another embodiment, the antisense nucleic acid molecule of the invention is an α-anomeric nucleic acid molecule. An α-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual β-units, the strands run parallel to each other. See, e.g., Gaultier, et al., 1987.  Nucl. Acids Res.  15: 6625-6641. The antisense nucleic acid molecule can also comprise a 2′-o-methylribonucleotide (See, e.g., Inoue, et al. 1987.  Nucl. Acids Res.  15: 6131-6148) or a chimeric RNA-DNA analogue (See, e.g., Inoue, et al., 1987.  FEBS Lett.  215: 327-330.  
      Ribozymes and PNA Moieties  
      Nucleic acid modifications include, by way of non-limiting example, modified bases, and nucleic acids whose sugar phosphate backbones are modified or derivatized. These modifications are carried out at least in part to enhance the chemical stability of the modified nucleic acid, such that they may be used, for example, as antisense binding nucleic acids in therapeutic applications in a subject.  
      In one embodiment, an antisense nucleic acid of the invention is a ribozyme. Ribozymes are catalytic RNA molecules with ribonuclease activity that are capable of cleaving a single-stranded nucleic acid, such as an mRNA, to which they have a complementary region. Thus, ribozymes (e.g., hammerhead ribozymes as described in Haselhoff and Gerlach 1988.  Nature  334: 585-591) can be used to catalytically cleave NOVX mRNA transcripts to thereby inhibit translation of NOVX mRNA. A ribozyme having specificity for a NOVX-encoding nucleic acid can be designed based upon the nucleotide sequence of a NOVX cDNA disclosed herein (i.e., SEQ ID NO:2n−1, wherein n is an integer between 1 and 606). For example, a derivative of a  Tetrahymena  L-19 IVS RNA can be constructed in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in a NOVX-encoding mRNA. See, e.g., U.S. Pat. No. 4,987,07to Cech, et al. and U.S. Pat. No. 5,116,742 to Cech, et al. NOVX mRNA can also be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules. See, e.g., Bartel et al., (1993)  Science  261:1411-1418.  
      Alternatively, NOVX gene expression can be inhibited by targeting nucleotide sequences complementary to the regulatory region of the NOVX nucleic acid (e.g., the NOVX promoter and/or enhancers) to form triple helical structures that prevent transcription of the NOVX gene in target cells. See, e.g., Helene, 1991.  Anticancer Drug Des.  6: 569-84; Helene, et al. 1992.  Ann. N.Y. Acad. Sci.  660: 27-36; Maher, 1992.  Bioassays  14: 807-15.  
      In various embodiments, the NOVX nucleic acids can be modified at the base moiety, sugar moiety or phosphate backbone to improve, e.g., the stability, hybridization, or solubility of the molecule. For example, the deoxyribose phosphate backbone of the nucleic acids can be modified to generate peptide nucleic acids. See, e.g., Hyrup, et al., 1996.  Bioorg Med Chem  4: 5-23. As used herein, the terms “peptide nucleic acids” or “PNAs” refer to nucleic acid mimics (e.g., DNA mimics) in which the deoxyribose phosphate backbone is replaced by a pseudopeptide backbone and only the four natural nucleotide bases are retained. The neutral backbone of PNAs has been shown to allow for specific hybridization to DNA and RNA under conditions of low ionic strength. The synthesis of PNA oligomer can be performed using standard solid phase peptide synthesis protocols as described in Hyrup, et al., 1996. supra; Perry-O&#39;Keefe, et al., 1996.  Proc. Natl. Acad. Sci. USA  93: 14670-14675.  
      PNAs of NOVX can be used in therapeutic and diagnostic applications. For example, PNAs can be used as antisense or antigene agents for sequence-specific modulation of gene expression by, e.g., inducing transcription or translation arrest or inhibiting replication. PNAs of NOVX can also be used, for example, in the analysis of single base pair mutations in a gene (e.g., PNA directed PCR clamping; as artificial restriction enzymes when used in combination with other enzymes, e.g., S 1  nucleases (See, Hyrup, et al., 1996.supra); or as probes or primers for DNA sequence and hybridization (See, Hyrup, et al., 1996, supra; Perry-O&#39;Keefe, et al., 1996. supra).  
      In another embodiment, PNAs of NOVX can be modified, e.g., to enhance their stability or cellular uptake, by attaching lipophilic or other helper groups to PNA, by the formation of PNA-DNA chimeras, or by the use of liposomes or other techniques of drug delivery known in the art. nFor example, PNA-DNA chimeras of NOVX can be generated that may combine the advantageous properties of PNA and DNA. Such chimeras allow DNA recognition enzymes (e.g., RNase H and DNA polymerases) to interact with the DNA portion while the PNA portion would provide high binding affinity and specificity. PNA-DNA chimeras can be linked using linkers of appropriate lengths selected in terms of base stacking, number of bonds between the nucleotide bases, and orientation (see, Hyrup, et al., 1996. supra). The synthesis of PNA-DNA chimeras can be performed as described in Hyrup, et al., 1996. supra and Finn, et al., 1996.  Nucl Acids Res  24: 3357-3363. For example, a DNA chain can be synthesized on a solid support using standard phosphoramidite coupling chemistry, and modified nucleoside analogs, e.g., 5′-(4-methoxytrityl)amino-5′-deoxy-thymidine phosphoramidite, can be used between the PNA and the 5′ end of DNA. See, e.g., Mag, et al., 1989.  Nucl Acid Res  17: 5973-5988. PNA monomers are then coupled in a stepwise manner to produce a chimeric molecule with a 5′ PNA segment and a 3′ DNA segment. See, e.g., Finn, et al., 1996. supra. Alternatively, chimeric molecules can be synthesized with a 5′ DNA segment and a 3′ PNA segment. See, e.g., Petersen, et al., 1975.  Bioorg. Med. Chem. Lett.  5: 1119-11124.  
      In other embodiments, the oligonucleotide may include other appended groups such as peptides (e.g., for targeting host cell receptors in vivo), or agents facilitating transport across the cell membrane (see, e.g., Letsinger, et al., 1989.  Proc. Natl. Acad. Sci. U.S.A.  86: 6553-6556; Lemaitre, et al., 1987.  Proc. Natl. Acad. Sci.  84: 648-652; PCT Publication No. WO88/09810) or the blood-brain barrier (see, e.g., PCT Publication No. WO 89/10134). In addition, oligonucleotides can be modified with hybridization triggered cleavage agents (see, e.g., Krol, et al., 1988.  BioTechniques  6:958-976) or intercalating agents (see, e.g., Zon, 1988.  Pharm. Res.  5: 539-549). To this end, the oligonucleotide may be conjugated to another molecule, e.g., a peptide, a hybridization triggered cross-linking agent, a transport agent, a hybridization-triggered cleavage agent, and the like.  
      NOVX Polypeptides  
      A polypeptide according to the invention includes a polypeptide including the amino acid sequence of NOVX polypeptides whose sequences are provided in any one of SEQ ID NO:2n, wherein n is an integer between 1 and 606. The invention also includes a mutant or variant protein any of whose residues may be changed from the corresponding residues shown in any one of SEQ ID NO:2n, wherein n is an integer between 1 and 606, while still encoding a protein that maintains its NOVX activities and physiological functions, or a functional fragment thereof.  
      In general, a NOVX variant that preserves NOVX-like function includes any variant in which residues at a particular position in the sequence have been substituted by other amino acids, and further include the possibility of inserting an additional residue or residues between two residues of the parent protein as well as the possibility of deleting one or more residues from the parent sequence. Any amino acid substitution, insertion, or deletion is encompassed by the invention. In favorable circumstances, the substitution is a conservative substitution as defined above.  
      One aspect of the invention pertains to isolated NOVX proteins, and biologically-active portions thereof, or derivatives, fragments, analogs or homologs thereof. Also provided are polypeptide fragments suitable for use as immunogens to raise anti-NOVX antibodies. In one embodiment, native NOVX proteins can be isolated from cells or tissue sources by an appropriate purification scheme using standard protein purification techniques. In another embodiment, NOVX proteins are produced by recombinant DNA techniques. Alternative to recombinant expression, a NOVX protein or polypeptide can be synthesized chemically using standard peptide synthesis techniques.  
      An “isolated” or “purified” polypeptide or protein or biologically-active portion thereof is substantially free of cellular material or other contaminating proteins from the cell or tissue source from which the NOVX protein is derived, or substantially free from chemical precursors or other chemicals when chemically synthesized. The language “substantially free of cellular material” includes preparations of NOVX proteins in which the protein is separated from cellular components of the cells from which it is isolated or recombinantly-produced. In one embodiment, the language “substantially free of cellular material” includes preparations of NOVX proteins having less than about 30% (by dry weight) of non-NOVX proteins (also referred to herein as a “contaminating protein”), more preferably less than about 20% of non-NOVX proteins, still more preferably less than about 10% of non-NOVX proteins, and most preferably less than about 5% of non-NOVX proteins. When the NOVX protein or biologically-active portion thereof is recombinantly-produced, it is also preferably substantially free of culture medium, i.e., culture medium represents less than about 20%, more preferably less than about 10%, and most preferably less than about 5% of the volume of the NOVX protein preparation.  
      The language “substantially free of chemical precursors or other chemicals” includes preparations of NOVX proteins in which the protein is separated from chemical precursors or other-chemicals that are involved in the synthesis of the protein. In one embodiment, the language “substantially free of chemical precursors or other chemicals” includes preparations of NOVX proteins having less than about 30% (by dry weight) of chemical precursors or non-NOVX chemicals, more preferably less than about 20% chemical precursors or non-NOVX chemicals, still more preferably less than about 10% chemical precursors or non-NOVX chemicals, and most preferably less than about 5% chemical precursors or non-NOVX chemicals.  
      Biologically-active portions of NOVX proteins include peptides comprising amino acid sequences sufficiently homologous to or derived from the amino acid sequences of the NOVX proteins (e.g., the amino acid sequence of SEQ ID NO:2n, wherein n is an integer between 1 and 606) that include fewer amino acids than the full-length NOVX proteins, and exhibit at least one activity of a NOVX protein. Typically, biologically-active portions comprise a domain or motif with at least one activity of the NOVX protein. A biologically-active portion of a NOVX protein can be a polypeptide which is, for example, 10, 25, 50, 100 or more amino acid residues in length.  
      Moreover, other biologically-active portions, in which other regions of the protein are deleted, can be prepared by recombinant techniques and evaluated for one or more of the functional activities of a native NOVX protein.  
      In an embodiment, the NOVX protein has an amino acid sequence of SEQ ID NO:2n, wherein n is an integer between 1 and 606. In other embodiments, the NOVX protein is substantially homologous to SEQ ID NO:2n, wherein n is an integer between 1 and 606, and retains the functional activity of the protein of SEQ ID NO:2n, wherein n is an integer between 1 and 606, yet differs in amino acid sequence due to natural allelic variation or mutagenesis, as described in detail, below. Accordingly, in another embodiment, the NOVX protein is a protein that comprises an amino acid sequence at least about 45% homologous to the amino acid sequence of SEQ ID NO:2n, wherein n is an integer between 1 and 606, and retains the functional activity of the NOVX proteins of SEQ ID NO:2n, wherein n is an integer between 1 and 606.  
      Determining Homology Between Two or More Sequences  
      To determine the percent homology of two amino acid sequences or of two nucleic acids, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in the sequence of a first amino acid or nucleic acid sequence for optimal alignmentwith a second amino or nucleic acid sequence). The amino acid residues or nucleotides at corresponding amino acid positions ornucleotide positions are then compared. When a position in the first sequence is occupied by the same amino acid residue or nucleotide as the corresponding position in the second sequence, then the molecules are homologous at that position (i.e., as used herein amino acid or nucleic acid “homology” is equivalent to amino acid or nucleic acid “identity”).  
      The nucleic acid sequence homology may be determined as the degree of identity between two sequences. The homology may be determined using computer programs known in the art, such as GAP software provided in the GCG program package. See, Needleman and Wunsch, 1970.  J Mol Biol  48: 443-453. Using GCG GAP software with the following settings for nucleic acid sequence comparison: GAP creation penalty of 5.0 and GAP extension penalty of 0.3, the coding region of the analogous nucleic acid sequences referred to above exhibits a degree of identity preferably of at least 70%, 75%, 80%, 85%, 90%, 95%, 98%, or 99%, with the CDS (encoding) part of the DNA sequence of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606.  
      The term “sequence identity” refers to the degree to which two polynucleotide or polypeptide sequences are identical on a residue-by-residue basis over a particular region of comparison. The term “percentage of sequence identity” is calculated by comparing two optimally aligned sequences over that region of comparison, determining the number of positions at which the identical nucleic acid base (e.g., A, T, C, G. U, or I, in the case of nucleic acids) occurs in both sequences to yield the number of matched positions, dividing the number of matched positions by the total number of positions in the region of comparison (i.e., the window size), and multiplying the result by 100 to yield the percentage of sequence identity. The term “substantial identity” as used herein denotes a characteristic of a polynucleotide sequence, wherein the polynucleotide comprises a sequence that has at least 80 percent sequence identity, preferably at least 85 percent identity and often 90 to 95 percent sequence identity, more usually at least 99 percent sequence identity as compared to a reference sequence over a comparison region.  
      Chimeric and Fusion Proteins  
      The invention also provides NOVX chimeric or fusion proteins. As used herein, a NOVX “chimeric protein” or “fusion protein” comprises a NOVX polypeptide operatively-linked to a non-NOVX polypeptide. An “NOVX polypeptide” refers to a polypeptide having an amino acid sequence corresponding to a NOVX protein of SEQ ID NO:2n, wherein n is an integer between 1 and 606, whereas a “non-NOVX polypeptide” refers to a polypeptide having an amino acid sequence corresponding to a protein that is not substantially homologous to the NOVX protein, e.g., a protein that is different from the NOVX protein and that is derived from the same or a different organism. Within a NOVX fusion protein the NOVX polypeptide can correspond to all or a portion of a NOVX protein. In one embodiment, a NOVX fusion protein comprises at least one biologically-active portion of a NOVX protein. In another embodiment, a NOVX fusion protein comprises at least two biologically-active portions of a NOVX protein. In yet another embodiment, a NOVX fusion protein comprises at least three biologically-active portions of a NOVX protein. Within the fusion protein, the term “operatively-linked” is intended to indicate that the NOVX polypeptide and the non-NOVX polypeptide are fused in-frame with one another. The non-NOVX polypeptide can be fused to the N-terminus or C-terminus of the NOVX polypeptide.  
      In one embodiment, the fusion protein is a GST-NOVX fusion protein in which the NOVX sequences are fused to the C-terminus of the GST (glutathione S-transferase) sequences. Such fusion proteins can facilitate the purification of recombinant NOVX polypeptides.  
      In another embodiment, the fusion protein is a NOVX protein containing a heterologous signal sequence at its N-terminus. In certain host cells (e.g., mammalian host cells), expression and/or secretion of NOVX can be increased through use of a heterologous signal sequence.  
      In yet another embodiment, the fusion protein is a NOVX-immunoglobulin fusion protein in which the NOVX sequences are fused to sequences derived from a member of the immunoglobulin protein family. The NOVX-immunoglobulin fusion proteins of the invention can be incorporated into pharmaceutical compositions and administered to a subject to inhibit an interaction between a NOVX ligand and a NOVX protein on the surface of a cell, to thereby suppress NOVX-mediated signal transduction in vivo. The NOVX-immunoglobulin fusion proteins can be used to affect the bioavailability of a NOVX cognate ligand. Inhibition of the NOVX ligand/NOVX interaction may be useful therapeutically for both the treatment of proliferative and differentiative disorders, as well as modulating (e.g. promoting or inhibiting) cell survival. Moreover, the NOVX-immunoglobulin fusion proteins of the invention can be used as immunogens to produce anti-NOVX antibodies in a subject, to purify NOVX ligands, and in screening assays to identify molecules that inhibit the interaction of NOVX with a NOVX ligand.  
      A NOVX chimeric or fusion protein of the invention can be produced by standard recombinant DNA techniques. For example, DNA fragments coding for the different polypeptide sequences are ligated together in-frame in accordance with conventional techniques, e.g., by employing blunt-ended or stagger-ended termini for ligation, restriction enzyme digestion to provide for appropriate termini, filling-in of cohesive ends as appropriate, alkaline phosphatase treatment to avoid undesirable joining, and enzymatic ligation. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA synthesizers. Alternatively, PCR amplification of gene fragments can be carried out using anchor primers that give rise to complementary overhangs between two consecutive gene fragments that can subsequently be annealed and reamplified to generate a chimeric gene sequence (see, e.g., Ausubel, et al. (eds.) C URRENT  P ROTOCOLS IN  M OLECULAR  B IOLOGY,  John Wiley &amp; Sons, 1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST polypeptide). A NOVX-encoding nucleic acid can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the NOVX protein.  
      NOVX Agonists and Antagonists  
      The invention also pertains to variants of the NOVX proteins that function as either NOVX agonists (i.e., mimetics) or as NOVX antagonists. Variants of the NOVX protein can be generated by mutagenesis (e.g., discrete point mutation or truncation of the NOVX protein). An agonist of the NOVX protein can retain substantially the same, or a subset of, the biological activities of the naturally occurring form of the NOVX protein. An antagonist of the NOVX protein can inhibit one or more of the activities of the naturally occurring form of the NOVX protein by, for example, competitively binding to a downstream or upstream member of a cellular signaling cascade which includes the NOVX protein. Thus, specific biological effects can be elicited by treatment with a variant of limited function. In one embodiment, treatment of a subject with a variant having a subset of the biological activities of the naturally occurring form of the protein has fewer side effects in a subject relative to treatment with the naturally occurring form of the NOVX proteins.  
      Variants of the NOVX proteins that function as either NOVX agonists (ie., mimetics) or as NOVX antagonists can be identified by screening combinatorial libraries of mutants (e.g., truncation mutants) of the NOVX proteins for NOVX protein agonist or antagonist activity. In one embodiment, a variegated library of NOVX variants is generated by combinatorial mutagenesis at the nucleic acid level and is encoded by a variegated gene library. A variegated library of NOVX variants can be produced by, for example, enzymatically ligating a mixture of synthetic oligonucleotides into gene sequences such that a degenerate set of potential NOVX sequences is expressible as individual polypeptides, or alternatively, as a set of larger fusion proteins (e.g., for phage display) containing the set of NOVX sequences therein. There are a variety of methods which can be used to produce libraries of potential NOVX variants from a degenerate oligonucleotide sequence. Chemical synthesis of a degenerate gene sequence can be performed in an automatic DNA synthesizer, and the synthetic gene then ligated into an appropriate expression vector. Use of a degenerate set of genes allows for the provision, in one mixture, of all of the sequences encoding the desired set of potential NOVX sequences. Methods for synthesizing degenerate oligonucleotides are well-known within the art. See, e.g., Narang, 1983.  Tetrahedron  39: 3; Itakura, et al., 1984.  Annu. Rev. Biochem.  53: 323; Itakura, et al., 1984.  Science  198: 1056; Ike, et al., 1983.  Nucl. Acids Res.  11: 477.  
      Polypeptide Libraries  
      In addition, libraries of fragments of the NOVX protein coding sequences can be used to generate a variegated population of NOVX fragments for screening and subsequent selection of variants of a NOVX protein. In one embodiment, a library of coding sequence fragments can be generated by treating a double stranded PCR fragment of a NOVX coding sequence with a nuclease under conditions wherein nicking occurs only about once per molecule, denaturing the double stranded DNA, renaturing the DNA to form double-stranded DNA that can include sense/antisense pairs from different nicked products, removing single stranded portions from reformed duplexes by treatment with SI nuclease, and ligating the resulting fragment library into an expression vector. By this method, expression libraries can be derived which encodes N-terminal and internal fragments of various sizes of the NOVX proteins.  
      Various techniques are known in the art for screening gene products of combinatorial libraries made by point mutations or truncation, and for screening cDNA libraries for gene products having a selected property. Such techniques are adaptable for rapid screening of the gene libraries generated by the combinatorial mutagenesis of NOVX proteins. The most widely used techniques, which are amenable to high throughput analysis, for screening large gene libraries typically include cloning the gene library into replicable expression vectors, transforming appropriate cells with the resulting library of vectors, and expressing the combinatorial genes under conditions in which detection of a desired activity facilitates isolation of the vector encoding the gene whose product was detected. Recursive ensemble mutagenesis (REM), a new technique that enhances the frequency of functional mutants in the libraries, can be used in combination with the screening assays to identify NOVX variants. See, e.g., Arkin and Yourvan, 1992.  Proc. Natl. Acad. Sci. USA  89: 7811-7815; Delgrave, et al., 1993.  Protein Engineering  6:327-331.  
      Anti-NOVX Antibodies  
      Included in the invention are antibodies to NOVX proteins, or fragments of NOVX proteins. The term “antibody” as used herein refers to immunoglobulin molecules and immunologically active portions of immunoglobulin (Ig) molecules, i.e., molecules that contain an antigen binding site that specifically binds (immunoreacts with) an antigen. Such antibodies include, but are not limited to, polyclonal, monoclonal, chimeric, single chain, F ab , F ab′  and F (ab′)2  fragments, and an F ab  expression library. In general, antibody molecules obtained from humans relates to any of the classes IgG, IgM, IgA, IgE and IgD, which differ from one another by the nature of the heavy chain present in the molecule. Certain classes have subclasses as well, such as IgG 1 , IgG 2 , and others. Furthermore, in humans, the light chain may be a kappa chain or a lambda chain. Reference herein to antibodies includes a reference to all such classes, subclasses and types of human antibody species.  
      An isolated protein of the invention intended to serve as an antigen, or a portion or fragment thereof, can be used as an immunogen to generate antibodies that immunospecifically bind the antigen, using standard techniques for polyclonal and monoclonal antibody preparation. The full-length protein can be used or, alternatively, the ! invention provides antigenic peptide fragments of the antigen for use as immunogens. An antigenic peptide fragment comprises at least 6 amino acid residues of the amino acid sequence of the full length protein, such as an amino acid sequence of SEQ ID NO:2n, wherein n is an integer between 1 and 606, and encompasses an epitope thereof such that X an antibody raised against the peptide forms a specific immune complex with the full length protein or with any fragment that contains the epitope. Preferably, the antigenic peptide comprises at least 10 amino acid residues, or at least 15 amino acid residues, or at least 20 amino acid residues, or at least 30 amino acid residues. Preferred epitopes encompassed by the antigenic peptide are regions of the protein that are located on its surface; commonly these are hydrophilic regions.  
      In certain embodiments of the invention, at least one epitope encompassed by the antigenic peptide is a region of NOVX that is located on the surface of the protein, e.g., a hydrophilic region. A hydrophobicity analysis of the human NOVX protein sequence will indicate which regions of a NOVX polypeptide are particularly hydrophilic and, therefore, are likely to encode surface residues useful for targeting antibody production. As a means for targeting antibody production, hydropathy plots showing regions of hydrophilicity and hydrophobicity may be generated by any method well known in the art, including, for example, the Kyte Doolittle or the Hopp Woods methods, either with or without Fourier transformation. See, e.g., Hopp and Woods, 1981,  Proc. Nat. Acad. Sci. USA  78: 3824-3828; Kyte and Doolittle 1982,  J. Mol. Biol.  157: 105-142, each incorporated herein by reference in their entirety. Antibodies that are specific for one or more domains within an antigenic protein, or derivatives, fragments, analogs or homologs thereof, are also provided herein.  
      I The term “epitope” includes any protein determinant capable of specific binding to an immunoglobulin or T-cell receptor. Epitopic determinants usually consist of chemically active surface groupings of molecules such as amino acids or sugar side chains and usually have specific three dimensional structural characteristics, as well as specific charge characteristics. A NOVX polypeptide or a fragment thereof comprises at least one antigenic epitope. An anti-NOVX antibody of the present invention is said to specifically bind to antigen NOVX when the equilibrium binding constant (K D ) is ≦1 μM, preferably ≦100 nM, more preferably ≦10 nM, and most preferably ≦100 pM to about 1 pM, as measured by assays including radioligand binding assays or similar assays known to skilled artisans.  
      A protein of the invention, or a derivative, fragment, analog, homolog or ortholog thereof, may be utilized as an immunogen in the generation of antibodies that immunospecifically bind these protein components.  
      Various procedures known within the art may be used for the production of polyclonal or monoclonal antibodies directed against a protein of the invention, or against derivatives, fragments, analogs homologs or orthologs thereof (see, for example, Antibodies: A Laboratory Manual, Harlow E, and Lane D, 1988, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., incorporated herein by reference). Some of these antibodies are discussed below.  
      Polyclonal Antibodies  
      For the production of polyclonal antibodies, various suitable host animals (e.g., rabbit, goat, mouse or other mammal) may be immunized by one or more injections with the native protein, a synthetic variant thereof, or a derivative of the foregoing. An appropriate immunogenic preparation can contain, for example, the naturally occurring immunogenic protein, a chemically synthesized polypeptide representing the immunogenic protein, or a recombinantly expressed immunogenic protein. Furthermore, the protein may be conjugated to a second protein known to be immunogenic in the mammal being immunized. Examples of such immunogenic proteins include but are not limited to keyhole limpet hemocyanin, serum albumin, bovine thyroglobulin, and soybean trypsin inhibitor. The preparation can further include an adjuvant. Various adjuvants used to increase the immunological response include, but are not limited to, Freund&#39;s (complete and incomplete), mineral gels (e.g., aluminum hydroxide), surface active substances (e.g., lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, dinitrophenbl, etc.), adjuvants usable in humans such as Bacille Calmette-Guerin and Corynebacterium parvum, or similar immunostimulatory agents. Additional examples of adjuvants which can be employed include MPL-TDM adjuvant (monophosphoryl Lipid A, synthetic trehalose dicorynomycolate).  
      The polyclonal antibody molecules directed against the immunogenic protein can be isolated from the mammal (e.g., from the blood) and further purified by well known techniques, such as affinity chromatography using protein A or protein G, which provide primarily the IgG fraction of immune serum. Subsequently, or alternatively, the specific antigen which is the target of the immunoglobulin sought, or an epitope thereof, may be immobilized on a column to purify the immune specific antibody by immunoaffinity chromatography. Purification of immunoglobulins is discussed, for example, by D. Wilkinson (The Scientist, published by The Scientist, Inc., Philadelphia Pa., Vol. 14, No. 8 (Apr. 17, 2000), pp. 25-28).  
      Monoclonal Antibodies  
      The term “monoclonal antibody” (MAb) or “monoclonal antibody composition”, as used herein, refers to a population of antibody molecules that contain only one molecular species of antibody molecule consisting of a unique light chain gene product and a unique heavy chain gene product. In particular, the complementarity determining regions (CDRs) of the monoclonal antibody are identical in all the molecules of the population. MAbs thus contain an antigen binding site capable of immunoreacting with a particular epitope of the antigen characterized by a unique binding affinity for it.  
      Monoclonal antibodies can be prepared using hybridoma methods, such as those described by Kohler and Milstein, Nature, 256:495 (1975). In a hybridoma method, a mouse, hamster, or other appropriate host animal, is typically immunized with an immunizing agent to elicit lymphocytes that produce or are capable of producing antibodies that will specifically bind to the immunizing agent. Alternatively, the lymphocytes can be immunized in vitro.  
      The immunizing agent will typically include the protein antigen, a fragment thereof or a fusion protein thereof. Generally, either peripheral blood lymphocytes are used if cells of human origin are desired, or spleen cells-or lymph node cells are used if non-human mammalian sources are desired. The lymphocytes are then fused with an immortalized cell line using a suitable fusing agent, such as polyethylene glycol, to form a hybridoma cell (Goding,  Monoclonal Antibodies: Principles and Practice,  Academic Press, (1986) pp. 59-103). Immortalized cell lines are usually transformed mammalian cells, particularly myeloma cells of rodent, bovine and human origin. Usually, rat or mouse myeloma cell lines are employed. The hybridoma cells can be cultured in a suitable culture medium that preferably contains one or more substances that inhibit the growth or survival of the unfused, immortalized cells. For example, if the parental cells lack the enzyme hypoxanthine guanine phosphoribosyl transferase (HGPRT or HPRT), the culture medium for the hybridomas typically will include hypoxanthine, aminopterin, and thymidine (“HAT medium”), which substances prevent the growth of HGPRT-deficient cells.  
      Preferred immortalized cell lines are those that fuse efficiently, support stable high level expression of antibody by the selected antibody-producing cells, and are sensitive to a medium such as HAT medium. More preferred immortalized cell lines are murine myeloma lines, which can be obtained, for instance, from the Salk Institute Cell Distribution Center, San Diego, Calif. and the American Type Culture Collection, Manassas, Virginia. Human myeloma and mouse-human heteromyeloma cell lines also have been described for the production of human monoclonal antibodies (Kozbor, J. Immunol., 133:3001 (1984); Brodeur et al., Monoclonal Antibody Production Techniques and Applications, Marcel Dekker, Inc., New York, (1987) pp. 51-63).  
      The culture medium in which the hybridoma cells are cultured can then be assayed for the presence of monoclonal antibodies directed against the antigen. Preferably, the binding specificity of monoclonal antibodies produced by the hybridoma cells is determined by immunoprecipitation or by an in vitro binding assay, such as radioimmunoassay (RIA) or enzyme-linked immunoabsorbent assay (ELISA). Such techniques and assays are known in the art. The binding affinity of the monoclonal antibody can, for example, be determined by the Scatchard analysis of Munson and Pollard, Anal. Biochem., 107:220 (1980). It is an objective, especially important in therapeutic applications of monoclonal antibodies, to identify antibodies having a high degree of specificity and a high binding affinity for the target antigen.  
      After the desired hybridoma cells are identified, the clones can be subcloned by limiting dilution procedures and grown by standard methods (Goding,1986). Suitable culture media for this purpose include, for example, Dulbecco&#39;s Modified Eagle&#39;s Medium and RPMI-1640 medium. Altematively,the hybridoma cells can be grown in vivo as ascites in a mammal.  
      The monoclonal antibodies secreted by the subclones can be isolated or purified from the culture medium or ascites fluid by conventional immunoglobulin purification procedures such as, for example, protein A-Sepharose, hydroxylapatite chromatography, gel electrophoresis, dialysis, or affinity chromatography.  
      The monoclonal antibodies can also be made by recombinant DNA methods, such as those described in U.S. Pat. No. 4,816,567. DNA encoding the monoclonal antibodies of the invention can be readily isolated and sequenced using conventional procedures (e.g., by using oligonucleotide probes that are capable of binding specifically to genes encoding the heavy and light chains of murine antibodies). The hybridoma cells of the invention serve as a preferred source of such DNA. Once isolated, the DNA can be placed into expression vectors, which are then transfected into host cells such as simian COS cells, Chinese hamster ovary (CHO) cells, or myeloma cells that do not otherwise produce immunoglobulin protein, to obtain the synthesis of monoclonal antibodies in the recombinant host cells. The DNA also can be modified, for example, by substituting the coding sequence for human heavy and light chain constant domains in place of the homologous murine sequences (U.S. Pat. No. 4,816,567; Morrison, Nature 368, 812-13 (1994)) or by covalently joining to the immunoglobulin coding sequence all or part of the coding sequence for a non immunoglobulin polypeptide. Such a non-immunoglobulin polypeptide can be substituted for the constant domains of an antibody of the invention, or can be substituted for the variable domains of one antigen-combining site of an antibody of the invention to create a chimeric bivalent antibody.  
      Humanized Antibodies  
      The antibodies directed against the protein antigens of the invention can further comprise humanized antibodies or human antibodies. These antibodies are suitable for administration to humans without engendering an immune response by the human against the administered immunoglobulin. Humanized forms of antibodies are chimeric immunoglobulins, immunoglobulin chains or fragments thereof (such as Fv, Fab, Fab′, F(ab′) 2  or other antigen-binding subsequences of antibodies) that are principally comprised of the sequence of a human immunoglobulin, and contain minimal sequence derived from a non-human immunoglobulin. Humanization can be performed following the method of Winter and co-workers (Jones et al.;,Nature, 321:522-525 (1986); Riechmann et al., Nature, 332:323-327 (1988); Verhoeyen et al., Science, 239:1534-1536 (1988)), by substituting rodent CDRs or CDR sequences for the corresponding sequences of a human antibody. (See also U.S. Pat. No. 5,225,539.) In some instances, Fv framework residues of the human immunoglobulin are replaced by corresponding non-human residues. Humanized antibodies can also comprise residues which are found neither in the recipient antibody nor in the imported CDR or framework sequences. In general, the humanized antibody will comprise substantially all of at least one, and typically two, variable domains, in which all or substantially all of the CDR regions correspond to those of a non-human immunoglobulin and all or substantially all of the framework regions are those of a human immunoglobulin consensus sequence. The humanized antibody optimally also will comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin (Jones et al., 1986; Riechmnann et al., 1988; and Presta, Curr. Op. Struct. Biol., 2:593-596 (1992)).  
      Human Antibodies  
      Fully human antibodies essentially relate to antibody molecules in which the entire sequence of both the light chain and the heavy chain, including the CDRs, arise from human genes. Such antibodies are termed “human antibodies”, or “fully human antibodies” herein. Human monoclonal antibodies can be prepared by the trioma technique; the human B-cell hybridoma technique (see Kozbor, et al., 1983 Immunol Today 4: 72) and the EBV hybridoma technique to produce human monoclonal antibodies (see Cole, et al., 1985 In: MONOCLONAL ANTIBODIES AND CANCER THERAPY, Alan R. Liss, Inc., pp. 77-96). Human monoclonal antibodies may be utilized in the practice of the present invention and may be produced by using human hybridomas (see Cote, et al., 1983. Proc Natl Acad Sci USA 80: 2026-2030) or by transforming human B-cells with Epstein Barr Virus in vitro (see Cole, et al., 1985 In: MONOCLONAL ANTIBODIES AND CANCER THERAPY, Alan R. Liss, Inc., pp. 77-96).  
      In addition, human antibodies can also be produced using additional techniques, including phage display libraries (Hoogenboom and Winter, J. Mol. Biol., 227:381 (1991); Marks et al., J. Mol. Biol., 222:581 (1991)). Similarly, human antibodies can be made by introducing human immunoglobulin loci into transgenic animals, e.g., mice in which the endogenous immunoglobulin genes have been partially or completely inactivated. Upon challenge, human antibody production is observed, which closely resembles that seen in humans in all respects, including gene rearrangement, assembly, and antibody repertoire. This approach is described, for example, in U.S. Pat. Nos. 5,545,807; 5,545,806; 5,569,825; 5,625,126; 5,633,425; 5,661,016, and in Marks et al. (Bio/Technology 10, 779-783 (1992)); Lonberg et al. (Nature 368 856-859 (1994)); Morrison ( Nature 368, 812-13 (1994)); Fishwild et al,( Nature Biotechnology 14, 845-51 (1996)); Neuberger (Nature Biotechnology 14, 826 (1996)); and Lonberg and Huszar (Intern. Rev. Immunol. 13 65-93 (1995)).  
      Human antibodies may additionally be produced using transgenic nonhuman animals which are modified so as to produce fully human antibodies rather than the animal&#39;s endogenous antibodies in response to challenge by an antigen. (See PCT publication WO94/02602). The endogenous genes encoding the heavy and light immunoglobulin chains in the nonhuman host have been incapacitated, and active loci encoding human heavy and light chain immunoglobulins are inserted into the host&#39;s genome. The human genes are incorporated, for example, using yeast artificial chromosomes containing the requisite human DNA segments. An animal which provides all the desired modifications is then obtained as progeny by crossbreeding intermediate transgenic animals containing fewer than the full complement of the modifications. The preferred embodiment of such a nonhuman animal is a mouse, and is termed the Xenomouse™ as disclosed in PCT publications WO 96/33735 and WO 96/34096. This animal produces B cells which secrete fully human immunoglobulins. The antibodies can be obtained directly from the animal after immunization with an immunogen of interest, as, for example, a preparation of a polyclonal antibody, or alternatively from immortalized B cells derived from the animal, such as hybridomas producing monoclonal antibodies. Additionally, the genes encoding the immunoglobulins with human variable regions can be recovered and expressed to obtain the antibodies directly, or can be further modified to obtain analogs of antibodies such as, for example, single chain Fv molecules.  
      An example of a method of producing a nonhuman host, exemplified as a mouse, lacking expression of an endogenous immunoglobulin heavy chain is disclosed in U.S. Pat. No. 5,939,598. It can be obtained by a method including deleting the J segment genes from at least one endogenous heavy chain locus in an embryonic stem cell to prevent rearrangement of the locus and to prevent formation of a transcript of a rearranged immunoglobulin heavy chain locus, the deletion being effected by a targeting vector containing a gene encoding a selectable marker; and producing from the embryonic stem cell a transgenic mouse whose somatic and germ cells contain the gene encoding the selectable marker.  
      A method for producing an antibody of interest, such as a human antibody, is disclosed in U.S. Pat. No. 5,916,771. It includes introducing an expression vector that contains a nucleotide sequence encoding a heavy chain into one mammalian host cell in culture, introducing an expression vector containing a nucleotide sequence encoding a light chain into another mammalian host cell, and fusing the two cells to form a hybrid cell. The hybrid cell expresses an antibody containing the heavy chain and the light chain.  
      In a further improvement on this procedure, a method for identifying a clinically relevant epitope on an immunogen, and a correlative method for selecting an antibody that binds immunospecifically to the relevant epitope with high affinity, are disclosed in PCT publication WO 99/53049.  
      F ab  Fragments and Single Chain Antibodies  
      According to the invention, techniques can be adapted for the production of single-chain antibodies specific to an antigenic protein of the invention (see e.g., U.S. Pat. No. 4,946,778). In addition, methods can be adapted for the construction of F ab  expression libraries (see e.g., Huse, et al., 1989 Science 246: 1275-1281) to allow rapid and effective identification of monoclonal F ab  fragments with the desired specificity for a protein or derivatives, fragments, analogs or homologs thereof. Antibody fragments that contain the idiotypes to a protein antigen may be produced by techniques known in the art including, but not limited to: (i) an F (ab′)2  fragment produced by pepsin digestion of an antibody molecule; (ii) an F ab  fragment generated by reducing the disulfide bridges of an F (ab′)2  fragment; (iii) an F ab  fragment generated by the treatment of the antibody molecule with papain and a reducing agent and (iv) F v  fragments.  
      Bispecific Antibodies  
      Bispecific antibodies are monoclonal, preferably human or humanized, antibodies that have binding specificities for at least two different antigens. In the present case, one of the binding specificities is for an antigenic protein of the invention. The second binding target is any other antigen, and advantageously is a cell-surface protein or receptor or receptor subunit.  
      Methods for making bispecific antibodies are known in the art. Traditionally, the recombinant production of bispecific antibodies is based on the co-expression of two immunoglobulin heavy-chain/light-chain pairs, where the two heavy chains have different specificities (Mlstein and Cuello, Nature, 305:537-539 (1983)). Because of the random assortment of immunoglobulin heavy and light chains, these hybridomas (quadromas) produce a potential mixture of ten different antibody molecules, of which only one has the correct bispecific structure. The purification of the correct molecule is usually accomplished by affinity chromatography steps. Similar procedures are disclosed in WO 93/08829, published 13 May 1993, and in Traunecker et al., EMBO J., 10:3655-3659 (1991).  
      Antibody variable domains with the desired binding specificities (antibody-antigen combining sites) can be fused to immunoglobulin constant domain sequences. The fusion preferably is with an immunoglobulin heavy-chain constant domain, comprising at least part of the hinge, CH2, and CH3 regions. It is preferred to have the first heavy-chain constant region (CH1) containing the site necessary for light-chain binding present in at least one of the fusions. DNAs encoding the immunoglobulin heavy-chain fusions and, if desired, the immunoglobulin light chain, are inserted into separate expression vectors, and are co-transfected into a suitable host organism. For further details of generating bispecific antibodies see, for example, Suresh et al., Methods in Enzymology, 121:210 (1986).  
      According to another approach described in WO 96/27011, the interface between a pair of antibody molecules can be engineered to maximize the percentage of heterodimers which are recovered from recombinant cell culture. The preferred interface comprises at least a part of the CH3 region of an antibody constant domain. In this method, one or more small amino acid side chains from the interface of the first antibody molecule are replaced with larger side chains (e.g. tyrosine or tryptophan). Compensatory “cavities” of identical or similar size to the large side chain(s) are created on the interface of the second antibody molecule by replacing large amino acid side chains with smaller ones (e.g. alanine or threonine). This provides a mechanism for increasing the yield of the heterodimer over other unwanted end-products such as homodimers.  
      Bispecific antibodies can be prepared as full length antibodies or antibody fragments (e.g. F(ab′) 2  bispecific antibodies). Techniques for generating bispecific antibodies from antibody fragments have been described in the literature. For example, bispecific antibodies can be prepared using chemical linkage. Brennan et al., Science 229:81 (1985) describe a procedure wherein intact antibodies are proteolytically cleaved to generate F(ab′) 2  fragments. These fragments are reduced in the presence of the dithiol complexing agent sodium arsenite to stabilize vicinal dithiols and prevent intermolecular disulfide formation. The Fab′ fragments generated are then converted to thionitrobenzoate (TNB) derivatives. One of the Fab′-TNB derivatives is then reconverted to the Fab′-thiol by reduction with mercaptoethylamnine and is mixed with an equimolar amount of the other Fab′-TNB derivative to form the bispecific antibody. The bispecific antibodies produced can be used as agents for the selective immobilization of enzymes.  
      Additionally, Fab′ fragments can be directly recovered from  E. coli  and chemically coupled to form bispecific antibodies. Shalaby et al., J. Exp. Med. 175:217-225 (1992) describe the production of a fully humanized bispecific antibody F(ab′) 2  molecule. Each Fab′ fragment was separately secreted from  E. coli  and subjected to directed chemical coupling in vitro to form the bispecific antibody. The bispecific antibody thus formed was able to bind to cells overexpressing the ErbB2 receptor and normal human T cells, as well as trigger the lytic activity of human cytotoxic lymphocytes against human breast tumor targets.  
      Various techniques for making and isolating bispecific antibody fragments directly from recombinant cell culture have also been described. For example, bispecific antibodies have been produced using leucine zippers. Kostelny et al., J. Immunol. 148(5):1547-1553 (1992). The leucine zipper peptides from the Fos and Jun proteins were linked to the Fab′ portions of two different antibodies by gene fusion. The antibody homodimers were reduced at the hinge region to form monomers and then re-oxidized to form the antibody heterodimers. This method can also be utilized for the production of antibody homodimers. The “diabody” technology described by Hollinger et al., Proc. Natl. Acad. Sci. USA 90:6444-6448 (1993) has provided an alternative mechanism for making bispecific antibody fragments. The fragments comprise a heavy-chain variable domain (V H ) connected to a light-chain variable domain (V L ) by a linker which is too short to allow pairing between the two domains on the same chain. Accordingly, the V H  and V L  domains of one fragment are forced to pair with the complementary V L  and V H  domains of another fragment, thereby forming two antigen-binding sites. Another strategy for making bispecific antibody fragments by the use of single-chain Fv (sFv) dimers has also been reported. See, Gruber et al., J. Imunol. 152:5368 (1994).  
      Antibodies with more than two valencies are contemplated. For example, trispecific antibodies can be prepared. Tutt et al., J. Immunol. 147:60 (1991).  
      Exemplary bispecific antibodies can bind to two different epitopes, at least one of which originates in the protein antigen of the invention. Alternatively, an anti-antigenic arm of an immunoglobulinr molecule can be combined with an arm which binds to a triggering molecule on a leukocyte such as a T-cell receptor molecule (e.g. CD2, CD3, CD28, or B7), or Fc receptors for IgG (FcγR), such as FcγRI (CD64), FcγRII (CD32) and FcγRIII (CD16) so as to focus cellular defense mechanisms to the cell expressing the particular antigen. Bispecific antibodies can also be used to direct cytotoxic agents to cells which express a particular antigen. These antibodies possess an antigen-binding arm and an arm which binds a cytotoxic agent or a radionuclide chelator, such as EOTUBE, DPTA, DOTA, or TETA. Another bispecific antibody of interest binds the protein antigen described herein and further binds tissue factor (TF).  
      Heteroconjugate Antibodies  
      Heteroconjugate antibodies are also within the scope of the present invention. Heteroconjugate antibodies are composed of two covalently joined antibodies. Such antibodies have, for example, been proposed to target immune system cells to unwanted cells (U.S. Pat. No. 4,676,980), and for treatment of HIV infection (WO 91/00360; WO 92/200373; EP 03089). It is contemplated that the antibodies can be prepared in vitro using known methods in synthetic protein chemistry, including those involving crosslinking agents. For example, immunotoxins can be constructed using a disulfide exchange reaction or by forming a thioether bond. Examples of suitable reagents for this purpose include iminothiolate and methyl-4-mercaptobutyrimidate and those disclosed, for example, in U.S. Pat. No. 4,676,980.  
      Effector Function Engineering  
      It can be desirable to modify the antibody of the invention with respect to effector function, so as to enhance, e.g., the effectiveness of the antibody in treating cancer. For example, cysteine residue(s) can be introduced into the Fc region, thereby allowing interchain disulfide bond formation in this region. The homodimeric antibody thus generated can have improved internalization capability and/or increased complement-mediated cell killing and antibody-dependent cellular cytotoxicity (ADCC). See Caron et al., J. Exp Med., 176: 1191-1195 (1992) and Shopes, J. Immunol., 148: 2918-2922 (1992). Homodimeric antibodies with enhanced anti-tumor activity can also be prepared using heterobifunctional cross-linkers as described in Wolff et al. Cancer Research, 53: 2560-2565 (1993). Alternatively, an antibody can be engineered that has dual Fc regions and can thereby have enhanced complement lysis and ADCC capabilities. See Stevenson et al., Anti-Cancer Drug Design, 3: 219-230 (1989).  
      Immunoconjugates  
      The invention also pertains to immunoconjugates comprising an antibody conjugated to a cytotoxic agent such as a chemotherapeutic agent, toxin (e.g., an enzymatically active toxin of bacterial, fungal, plant, or animal origin, or fragments thereof), or a radioactive isotope (i.e., a radioconjugate).  
      Chemotherapeutic agents useful in the generation of such immunoconjugates have been described above. Enzymatically active toxins and fragments thereof that can be used include diphtheria A chain, nonbinding active fragments of diphtheria toxin, exotoxin A chain (from  Pseudomonas aeruginosa ), ricin A chain, abrin A chain, modeccin A chain, alpha-sarcin,  Aleurites fordii  proteins, dianthin proteins,  Phytolaca americana  proteins (PAPI, PAPII, and PAP-S), momordica charantia inhibitor, curcin, crotin, sapaonaria officinalis inhibitor, gelonin, mitogellin, restrictocin, phenomycin, enomycin, and the tricothecenes. A variety of radionuclides are available for the production of radioconjugated antibodies. Examples include  212 Bi,  131 I,  131 In,  90 Y, and  186 Re.  
      Conjugates of the antibody and cytotoxic agent are made using a variety of bifunctional protein-coupling agents such as N-succinimidyl-3-(2-pyridyldithiol) propionate (SPDP), iminothiolane (IT), bifunctional derivatives of imidoesters (such as dimethyl adipimidate HCL), active esters (such as disuccinimidyl suberate), aldehydes (such as glutareldehyde), bis-azido compounds (such as bis (p-azidobenzoyl) hexanediamine), bis-diazonium derivatives (such as bis-(p-diazoniumbenzoyl)-ethylenediamine), diisocyanates (such as tolyene 2,6-diisocyanate), and bis-active fluorine compounds (such as 1,5-difluoro-2,4-dinitrobenzene). For example, a ricin immunotoxin can be prepared as described in Vitetta et al.,  Science,  238: 1098 (1987). Carbon-14-labeled 1-isothiocyanatobenzyl-3-methyldiethylene triaminepentaacetic acid (MX-DTPA) is an exemplary chelating agent for conjugation of radionucleotide to the antibody. See WO94/11026.  
      In another embodiment, the antibody can be conjugated to a “receptor” (such streptavidin) for utilization in tumor pretargeting wherein the antibody-receptor conjugate is administered to the patient, followed by removal of unbound conjugate from the circulation using a clearing agent and then administration of a “ligand” (e.g., avidin) that is in turn conjugated to a cytotoxic agent.  
      Immunoliposomes  
      The antibodies disclosed herein can also be formulated as immunoliposomes. Liposomes containing the antibody are prepared by methods known in the art, such as described in Epstein et al., Proc. Natl. Acad. Sci. USA, 82: 3688 (1985); Hwang et al., Proc. Natl Acad. Sci. USA, 77: 4030 (1980); and U.S. Pat. Nos. 4,485,045 and 4,544,545. Liposomes with enhanced circulation time are disclosed in U.S. Pat. No. 5,013,556.  
      Particularly useful liposomes can be generated by the reverse-phase evaporation method with a lipid composition comprising phosphatidylcholine, cholesterol, and PEG-derivatized phosphatidylethanolamine (PEG-PE). Liposomes are extruded through filters of defined pore size to yield liposomes with the desired diameter. Fab′ fragments of the antibody of the present invention can be conjugated to the liposomes as described in Martin et al., J. Biol. Chem., 257: 286-288 (1982) via a disulfide-interchange reaction. A chemotherapeutic agent (such as Doxorubicin) is optionally contained within the liposome. See Gabizon et al., J. National Cancer Inst., 81(19): 1484 (1989).  
      Diagnostic Applications of Antibodies Directed Against the Proteins of the Invention  
      In one embodiment, methods for the screening of antibodies that possess the desired specificity include, but are not limited to, enzyme linked immunosorbent assay (ELISA) and other immunologically mediated techniques known within the art. In a specific embodiment, selection of antibodies that are specific to a particular domain of an NOVX protein is facilitated by generation of hybridomas that bind to the fragment of an NOVX protein possessing such a domain. Thus, antibodies that are specific for a desired domain within an NOVX protein, or derivatives, fragments, analogs or homologs thereof, are also provided herein.  
      Antibodies directed against a NOVX protein of the invention may be used in methods known within the art relating to the localization and/or quantitation of a NOVX protein (e.g., for use in measuring levels of the NOVX protein within appropriate physiological samples, for use in diagnostic methods, for use in imaging the protein, and the like). In a given embodiment, antibodies specific to a NOVX protein, or derivative, fragment, analog or homolog thereof, that contain the antibody derived antigen binding domain, are utilized as pharmacologically active compounds (referred to hereinafter as “Therapeutics”).  
      An antibody specific for a NOVX protein of the invention (e.g., a monoclonal antibody or a polyclonal antibody) can be used to isolate a NOVX polypeptide by standard techniques, such as immunoaffinity, chromatography or immunoprecipitation. An antibody to a NOVX polypeptide can facilitate the purification of a natural NOVX antigen from cells, or of a recombinantly produced NOVX antigen expressed in host cells. Moreover, such an anti-NOVX antibody can be used to detect the antigenic NOVX protein (e.g., in a cellular lysate or cell supernatant) in order to evaluate the abundance and pattern of expression of the antigenic NOVX protein. Antibodies directed against a NOVX protein can be used diagnostically to monitor protein levels in tissue as part of a clinical testing procedure, e.g., to, for example, determine the efficacy of a given treatment regimen. Detection can be facilitated by coupling (ie., physically linking) the antibody to a detectable substance. Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, β-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include  125 I,  131 I,  35 S or  3 H.  
      Antibody Therapeutics  
      Antibodies of the invention, including polyclonal, monoclonal, humanized and fully human antibodies, may used as therapeutic agents. Such agents will generally be employed to treat or prevent a disease or pathology in a subject. An antibody preparation, preferably one having high specificity and high affinity for its target antigen, is administered to the subject and will generally have an effect due to its binding with the target. Such an effect may be one of two kinds, depending on the specific nature of the interaction between the given antibody molecule and the target antigen in question. In the first instance, administration of the antibody may abrogate or inhibit the binding of the target with an endogenous ligand to which it naturally binds. In this case, the antibody binds to the target and masks a binding site of the naturally occurring ligand, wherein the ligand serves as an effector molecule. Thus the receptor mediates a signal transduction pathway for which ligand is responsible.  
      Alternatively, the effect may be one in which the antibody elicits a physiological result by virtue of binding to an effector binding site on the target molecule. In this case the target, a receptor having an endogenous ligand which may be absent or defective in the disease or pathology, binds the antibody as a surrogate effector ligand, initiating a receptor-based signal transduction event by the receptor.  
      A therapeutically effective amount of an antibody of the invention relates generally to the amount needed to achieve a therapeutic objective. As noted above, this may be a binding interaction between the antibody and its target antigen that, in certain cases, interferes with the functioning of the target, and in other cases, promotes a physiological response. The amount required to be administered will furthermore depend on the binding affinity of the antibody for its specific antigen, and will also depend on the rate at which an administered antibody is depleted from the free volume other subject to which it is administered. Common ranges for therapeutically effective dosing of an antibody or antibody fragment of the invention may be, by way of nonlimiting example, from about 0.1 mg/kg body weight to about 50 mg/kg body weight. Common dosing frequencies may range, for example, from twice daily to once a week.  
      Pharmaceutical Compositions of Antibodies  
      Antibodies specifically binding a protein of the invention, as well as other molecules identified by the screening assays disclosed herein, can be administered for the treatment of various disorders in the form of pharmaceutical cormpositions. Principles and considerations involved in preparing such compositions, as well as guidance in the choice of components are provided, for example, in Remington: The Science And Practice Of Pharmacy 19th ed. (Alfonso R. Gennaro, et al., editors) Mack Pub. Co., Easton, Pa.: 1995; Drug Absorption Enhancement: Concepts, Possibilities, Limitations, And Trends, Harwood Academic Publishers, Langhorne, Pa., 1994; and Peptide And Protein Drug Delivery (Advances In Parenteral Sciences, Vol. 4), 1991, M. Dekker, New York.  
      If the antigenic protein is intracellular and whole antibodies are used as inhibitors, internalizing antibodies are preferred. However, liposomes can also be used to deliver the antibody, or an antibody fragment, into cells. Where antibody fragments are used, the smallest inhibitory fragment that specifically binds to the binding domain of the target protein is preferred. For example, based upon the variable-region sequences of an antibody, peptide molecules can be designed that retain the ability to bind the target protein sequence. Such peptides can be synthesized chemically and/or produced by recombinant DNA technology. See, e.g., Marasco et al., Proc. Natl. Acad. Sci. USA, 90: 7889-7893 (1993). The formulation herein can also contain more than one active compound as necessary for the particular indication being treated, preferably those with complementary activities that do not adversely affect each other. Alternatively, or in addition, the composition can comprise an agent that enhances its function, such as, for example, a cytotoxic agent, cytokine, chemotherapeutic agent, or growth-inhibitory agent. Such molecules are suitably present in combination in amounts that are effective for the purpose intended.  
      The active ingredients can also be entrapped in microcapsules prepared, for example, by coacervation techniques or by interfacial polymerization, for example, hydroxymethylcellulose or gelatin-microcapsules and poly-(methylmethacrylate) microcapsules, respectively, in colloidal drug delivery systems (for example, liposomes, albumin microspheres, microemulsions, nano-particles, and nanocapsules) or in macroemulsions.  
      The formulations to be used for in vivo administration must be sterile. This is readily accomplished by filtration through sterile filtration membranes.  
      Sustained-release preparations can be prepared. Suitable examples of sustained-release preparations include semipermeable matrices of solid hydrophobic polymers containing the antibody, which matrices are in the form of shaped articles, e.g., films, or microcapsules. Examples of sustained-release matrices include polyesters, hydrogels (for example, poly(2-hydroxyethyl-methacrylate), or poly(vinylalcohol)), polylactides (U.S. Pat. No. 3,773,919), copolymers of L-glutamic acid and γ ethyl-L-glutamate, non-degradable ethylene-vinyl acetate, degradable lactic acid-glycolic acid copolymers such as the LUPRON DEPOT™ (injectable microspheres composed of lactic acid-glycolic acid copolymer and leuprolide acetate), and poly-D-(−)-3-hydroxybutyric acid. While polymers such as ethylene-vinyl acetate and lactic acid-glycolic acid enable release of molecules for over 100 days, certain hydrogels release proteins for shorter time periods.  
      ELISA Assay  
      An agent for detecting an analyte protein is an antibody capable of binding to an analyte protein, preferably an antibody with a detectable label. Antibodies can be polyclonal, or more preferably, monoclonal. An intact antibody, or a fragment thereof (e.g., F ab  or F (ab)2 ) can be used. The term “labeled”, with regard to the probe or antibody, is intended to encompass direct labeling of the probe or antibody by coupling (i.e., physically linking) a detectable substance to the probe or antibody, as well as indirect labeling of the probe or antibody by reactivity with another reagent that is directly labeled. Examples of indirect labeling include detection of a primary antibody using a fluorescently-labeled secondary antibody and end-labeling of a DNA probe with biotin such that it can be detected with fluorescently-labeled streptavidin. The term “biological sample” is intended to include tissues, cells and biological fluids isolated from a subject, as well as tissues, cells and fluids present within a subject. Included within the usage of the term “biological sample”, therefore, is blood and a fraction or component of blood including blood serum, blood plasma, or lymph. That is, the detection method of the invention can be used to detect an analyte mRNA, protein, or genomic DNA in a biological sample in vitro as well as in vivo. For example, in vitro techniques for detection of an analyte mRNA include Northern hybridizations and in situ hybridizations. In vitro techniques for detection of an analyte protein include enzyme linked immunosorbent assays (ELISAs), Western blots, immunoprecipitations, and immunofluorescence. In vitro techniques for detection of an analyte genomic DNA include Southern hybridizations. Procedures for conducting immunoassays are described, for example in “ELISA: Theory and Practice: Methods in Molecular Biology”, Vol. 42, J. R. Crowther (Ed.) Human Press, Totowa, N.J., 1995; “Immunoassay”, E. Diamandis and T. Christopoulus, Academic Press, Inc., San Diego, Calif., 1996; and “Practice and Theory of Enzyme Immunoassays”, P. Tijssen, Elsevier Science Publishers, Amsterdam, 1985. Furthermore, in vivo techniques for detection of an analyte protein include introducing into a subject a labeled anti-an analyte protein antibody. For example, the antibody can be labeled with a radioactive marker whose presence and location in a subject can be detected by standard imaging techniques.  
      NOVX Recombinant Expression Vectors and Host Cells  
      Another aspect of the invention pertains to vectors, preferably expression vectors, containing a nucleic acid encoding a NOVX protein, or derivatives, fragments, analogs or homologs thereof. As used herein, the term “vector” refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked. One type of vector is a “plasmid”, which refers to a circular double stranded DNA loop into which additional DNA segments can be ligated. Another type of vector is a viral vector, wherein additional DNA segments can be ligated into the viral genome. Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g., bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) are integrated into the genome of a host cell upon introduction into the host cell, and thereby are replicated along with the host genome. Moreover, certain vectors are capable of directing the expression of genes to which they are operatively-linked. Such vectors are referred to herein as “expression vectors”. In general, expression vectors of utility in recombinant DNA techniques are often in the form of plasmids. In the present specification, “plasmid” and “vector” can be used interchangeably as the plasmid is the most commonly used form of vector. However, the invention is intended to include such other forms of expression vectors, such as viral vectors (e.g., replication defective retroviruses, adenoviruses and adeno-associated viruses), which serve equivalent functions.  
      The recombinant expression vectors of the invention comprise a nucleic acid of the invention in a form suitable for expression of the nucleic acid in a host cell, which means that the recombinant expression vectors include one or more regulatory sequences, selected on the basis of the host cells to be used for expression, that is operatively-linked to the nucleic acid sequence to be expressed. Within a recombinant expression vector, “operably-linked” is intended to mean that the nucleotide sequence of interest is linked to the regulatory sequence(s) in a manner that allows for expression of the nucleotide sequence (e.g.; in an in vitro transcription/translation system or in a host cell when the vector is introduced into the host cell).  
      The term “regulatory sequence” is intended to includes promoters, enhancers and other expression control elements (e.g., polyadenylation signals). Such regulatory sequences are described, for example, in Goeddel, G ENE  E XPRESSION  T ECHNOLOGY:  M ETHODS IN  E NZYMOLOGY  185, Academic Press, San Diego, Calif. (1990). Regulatory sequences include those that direct constitutive expression of a nucleotide sequence in many types of host cell and those that direct expression of the nucleotide sequence only in certain host cells (e.g., tissue-specific regulatory sequences). It will be appreciated by those skilled in the art that the design of the expression vector can depend on such factors as the choice of the host cell to be transformed, the level of expression of protein desired, etc. The expression vectors of the invention can be introduced into host cells to thereby produce proteins or peptides, including fusion proteins or peptides, encoded by nucleic acids as described herein (e.g., NOVX proteins, mutant forms of NOVX proteins, fusion proteins, etc.).  
      The recombinant expression vectors of the invention can be designed for expression of NOVX proteins in prokaryotic or eukaryotic cells. For example, NOVX proteins can be expressed in bacterial cells such as  Escherichia coli,  insect cells (using baculovirus expression vectors) yeast cells or mammalian cells. Suitable host cells are discussed further in Goeddel, G ENE  E XPRESSION  T ECHNOLOGY:  M ETHODS IN  E NZYMOLOGY  185, Academic Press, San Diego, Calif. (1990). Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example using T7 promoter regulatory sequences and 17 polymerase.  
      Expression of proteins in prokaryotes is most often carried out in  Escherichia coli  with vectors containing constitutive or inducible promoters directing the expression of either fusion or non-fusion proteins. Fusion vectors add a number of amino acids to a protein encoded therein, usually to the amino terminus of the recombinant protein. Such fusion vectors typically serve three purposes: (i) to increase expression of recombinant protein; (ii) to increase the solubility of the recombinant protein; and (iii) to aid in the purification of the recombinant protein by acting as a ligand in affinity purification. Often, in fusion expression vectors, a proteolytic cleavage site is introduced at the junction of the fusion moiety and the recombinant protein to enable separation of the recombinant protein from the fusion moiety subsequent to purification of the fusion protein. Such enzymes, and their cognate recognition sequences, include Factor Xa, thrombin and enterokinase. Typical fusion expression vectors include pGEX (Pharmacia Biotech Inc; Smith and Johnson, 1988.  Gene  67: 31-40), pMAL (New England Biolabs, Beverly, Mass.) and pRIT5 (Pharmacia, Piscataway, N.J.) that fuse glutathione S-transferase (GST), maltose E binding protein, or protein A, respectively, to the target recombinant protein.  
      Examples of suitable inducible non-fusion  E. coli  expression vectors include pTrc (Amrann et al., (1988)  Gene  69:301-315) and pET 11d (Studier et al., G ENE  E XPRESSION  T ECHNOLOGY:  M ETHODS IN  E NZYMOLOGY  185, Academic Press, San Diego, Calif. (1990) 60-89).  
      One strategy to maximize recombinant protein expression in  E. coli  is to express the protein in a host bacteria with an impaired capacity to proteolytically cleave the recombinant protein. See, e.g., Gottesman, G ENE  E XPRESSION  T ECHNOLOGY:  M ETHODS IN  E NZYMOLOGY  185, Academic Press, San Diego, Calif. (1990) 119-128. Another strategy is to alter the nucleic acid sequence of the nucleic acid to be inserted into an expression vector so that the individual codons for each amino acid are those preferentially utilized in  E. coli  (see, e.g., Wada, et al., 1992.  Nucl. Acids Res.  20: 2111-2118). Such alteration of nucleic acid sequences of the invention can be carried out by standard DNA synthesis techniques.  
      In another embodiment, the NOVX expression vector is a yeast expression vector. Examples of vectors for expression in yeast  Saccharomyces cerivisae  include pYepSec1 (Baldari, et al., 1987.  EMBO J.  6: 229-234), pMFa (Kurjan and Herskowitz, 1982.  Cell  30: 933-943), pJRY88 (Schultz et al., 1987.  Gene  54: 113-123), pYES2 (Invitrogen Corporation, San Diego, Calif.), and picZ (In Vitrogen Corp, San Diego, Calif.).  
      Alternatively, NOVX can be expressed in insect cells using baculovirus expression vectors. Baculovirus vectors available for expression of proteins in cultured insect cells (e.g., SF9 cells) include the pAc series (Smith, et al., 1983.  Mol. Cell. Biol.  3: 2156-2165) and the pVL series (Lucklow and Summers, 1989.  Virology  170: 31-39).  
      In yet another embodiment, a nucleic acid of the invention is expressed in mammalian cells using a mammalian expression vector. Examples of mammalian expression vectors include pCDM8 (Seed, 1987.  Nature  329: 840) and pMT2PC (Kaufman, et al., 1987.  EMBO J.  6: 187-195). When used in mammalian cells, the expression vector&#39;s control functions are often provided by viral regulatory elements. For example, commonly used promoters are derived from polyoma, adenovirus 2, cytomegalovirus, and simian virus 40. For other suitable expression systems for both prokaryotic and eukaryotic cells see, e.g., Chapters 16 and 17 of Sambrook, et al., M OLECULAR  C LONING:  A L ABORATORY  M ANUAL.  2nd ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989.  
      In another embodiment, the recombinant mammalian expression vector is capable of directing expression of the nucleic acid preferentially in a particular cell type (e.g., tissue-specific regulatory elements are used to express the nucleic acid). Tissue-specific regulatory elements are known in the art. Non-limiting examples of suitable tissue-specific promoters include the albumin promoter (liver-specific; Pinkert, et al., 1987.  Genes Dev.  1: 268-277), lymphoid-specific promoters (Calame and Eaton, 1988.  Adv. Immunol.  43: 235-275), in particular promoters of T cell receptors (Winoto and Baltimore, 1989.  EMBO J.  8: 729-733) and immunoglobulins (Banerji, et al., 1983. Cell 33: 729-740; Queen and Baltimore, 1983.  Cell  33: 741-748), neuron-specific promoters (e.g., the neurofilament promoter; Byrne and Ruddle, 1989.  Proc. Natl. Acad. Sci USA  86: 5473-5477), pancreas-specific promoters (Edlund, et al., 1985.  Science  230: 912-916), and mammary gland-specific promoters (e.g., milk whey promoter; U.S. Pat. No. 4,873,316 and European Application Publication No. 264,166). Developmentally-regulated promoters are also encompassed, e.g., the murine hox promoters (Kessel and Gruss, 1990.  Science  249: 374-379) and the α-fetoprotein promoter (Campes and Tilghman, 1989.  Genes Dev.  3: 537-546).  
      The invention further provides a recombinant expression vector comprising a DNA molecule of the invention cloned into the expression vector in an antisense orientation. That is, the DNA molecule is operatively-linked to a regulatory sequence in a manner that allows for expression (by transcription of the DNA molecule) of an RNA molecule that is antisense to NOVX mRNA. Regulatory sequences operatively linked to a nucleic acid cloned in the antisense orientation can be chosen that direct the continuous expression of the antisense RNA molecule in a variety of cell types, for instance viral promoters and/or enhancers, or regulatory sequences can be chosen that direct constitutive, tissue specific or cell type specific expression of antisense RNA. The antisense expression vector can be in the form of a recombinant plasrid, phagemid or attenuated virus in which antisense nucleic acids are produced under the control of a high efficiency regulatory region, the activity of which can be determined by the cell type into which the vector is introduced. For a discussion of the regulation of gene expression using antisense genes see, e.g., Weintraub, et al., “Antisense RNA as a molecular tool for genetic analysis,”  Reviews—Trends in Genetics,  Vol. 1(1) 1986.  
      Another aspect of the invention pertains to host cells into which a recombinant expression vector of the invention has been introduced. The terms “host cell” and “recombinant host cell” are used interchangeably herein. It is understood that such terms refer not only to the particular subject cell but also to the progeny or potential progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but are still included within the scope of the term as used herein.  
      A host cell can be any prokaryotic or eukaryotic cell. For example, NOVX protein can be expressed in bacterial cells such as  E. coli  , insect cells, yeast or mammalian cells (such as Chinese hamster ovary cells (CHO) or COS cells). Other suitable host cells are known to those skilled in the art.  
      Vector DNA can be introduced into prokaryotic or eukaryotic cells via conventional transformation or transfection techniques. As used herein, the terms “transformation” and “transfection” are intended to refer to a variety of art-recognized techniques for introducing foreign nucleic acid (e.g., DNA) into a host cell, including calcium phosphate or calcium chloride co-precipitation, DEAE-dextran-mediated transfection, lipofection, or electroporation. Suitable methods for transforming or transfecting host cells can be found in Sambrook, et al. (M OLECULAR  C LONING:  A L ABORATORY  M ANUAL.  2nd ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989), and other laboratory manuals.  
      For stable transfection of mammalian cells, it is known that, depending upon the expression vector and transfection technique used, only a small fraction of cells may integrate the foreign DNA into their genome. In order to identify and select these integrants, a gene that encodes a selectable marker (e.g., resistance to antibiotics) is generally introduced into the host cells along with the gene of interest. Various selectable markers include those that confer resistance to drugs, such as G418, hygromycin and methotrexate. Nucleic acid encoding a selectable marker can be introduced into a host cell on the same vector as that encoding NOVX or can be introduced on a separate vector. Cells stably transfected with the introduced nucleic acid can be identified by drug selection (e.g., cells that have incorporated the selectable marker gene will survive, while the other cells die).  
      A host cell of the invention, such as a prokaryotic or eukaryotic host cell in culture, can be used to produce (i.e., express) NOVX protein. Accordingly, the invention further provides methods for producing NOVX protein using the host cells of the invention. In one embodiment, the method comprises culturing the host cell of invention (into which a recombinant expression vector encoding NOVX protein has been introduced) in a suitable medium such that NOVX protein is produced. In another embodiment, the method further comprises isolating NOVX protein from the medium or the host cell.  
      Transgenic NOVX Animals  
      The host cells of the invention can also be used to produce non-human transgenic animals. For example, in one embodiment, a host cell of the invention is a fertilized oocyte or an embryonic stem cell into which NOVX protein-coding sequences have been introduced. Such host cells can then be used to create non-human transgenic animals in which exogenous NOVX sequences have been introduced into their genome or homologous recombinant animals in which endogenous NOVX sequences have been altered. Such animals are useful for studying the function and/or activity of NOVX protein and for identifying and/or evaluating modulators of NOVX protein activity. As used herein, a “transgenic animal” is a non-human animal, preferably a mammal, more preferably a rodent such as a rat or mouse, in which one or more of the cells of the animal. includes a transgene. Other examples of transgenic animals include non-human primates, sheep, dogs, cows, goats, chickens, amphibians, etc. A transgene is exogenous DNA that is integrated into the genome of a cell from which a transgenic animal develops and that remains in the genome of the mature animal, thereby directing the expression of an encoded gene product in one or more cell types or tissues of the transgenic animal. As used herein, a “homologous recombinant animal” is a non-human animal, preferably a mammal, more preferably a mouse, in which an endogenous NOVX gene has been altered by homologous recombination between the endogenous gene and an exogenous DNA molecule introduced into a cell of the animal, e.g., an embryonic cell of the animal, prior to development of the animal.  
      A transgenic animal of the invention can be created by introducing NOVX-encoding nucleic acid into the male pronuclei of a fertilized oocyte (e.g., by microinjection, retroviralinfection) and allowing the oocyte to develop in a pseudopregnant female foster animal. The human NOVX cDNA sequences, i.e., any one of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, can be introduced as a transgene into the genome of a non-human animal. Alternatively, a non-human homologue of the human NOVX gene, such as a mouse NOVX gene, can be isolated based on hybridization to the human NOVX cDNA (described further supra) and used as a transgene. Intronic sequences and polyadenylation signals can also be included in the transgene to increase the efficiency of expression of the transgene. A tissue-specific regulatory sequence(s) can be operably-linked to the NOVX transgene to direct expression of NOVX protein to particular cells. Methods for generating transgenic animals via embryo manipulation and microinjection, particularly animals such as mice, have become conventional in the art and are described, for example, in U.S. Pat. Nos. 4,736,866; 4,870,009; and 4,873,191; and Hogan, 1986. In: M ANIPULATING THE  M OUSE  E MBRYO,  Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. Similar methods are used for production of other transgenic animals. A transgenic founder animal can be identified based upon the presence of the NOVX transgene in its genome and/or expression of NOVX mRNA in tissues or cells of the animals. A transgenic founder animal can then be used to breed additional animals carrying the transgene. Moreover, transgenic animals carrying a transgene-encoding NOVX protein can further be bred to other transgenic animals carrying other transgenes.  
      To create a homologous recombinant animal, a vector is prepared which contains at least a portion of a NOVX gene into which a deletion, addition or substitution has been introduced to thereby alter, e.g., functionally disrupt, the NOVX gene. The NOVX gene can be a human gene (e.g., the cDNA of any one of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606), but more preferably, is a non-human homologue of a human NOVX gene. For example, a mouse homologue of human NOVX gene of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, can be used to construct a homologous recombination vector suitable for altering an endogenous NOVX gene in the mouse genome. In one embodiment, the vector is designed such that, upon homologous recombination, the endogenous NOVX gene is functionally disrupted (i.e., no longer encodes a functional protein; also referred to as a “knock out” vector).  
      Alternatively, the vector can be designed such that, upon homologous recombination, the endogenous NOVX gene is mutated or otherwise altered but still encodes functional protein (e.g., the upstream regulatory region can be altered to thereby alter the expression of the endogenous NOVX protein). In the homologous recombination vector, the altered portion of the NOVX gene is flanked at its 5′- and 3′-termini by additional nucleic acid of the NOVX gene to allow for homologous recombination to occur between the exogenous NOVX gene carried by the vector and an endogenous NOVX gene in an embryonic stem cell. The additional flanking NOVX nucleic acid is of sufficient length for successful homologous recombination with the endogenous gene. Typically, several kilobases of flanking DNA (both at the 5′- and 3′-termini) are included in the vector. See, e.g., Thomas, et al., 1987.  Cell  51: 503 for a description of homologous recombination vectors. The vector is ten introduced into an embryonic stem cell line (e.g., by electroporation) and cells in which the introduced NOVX gene has homologously-recombined with the endogenous NOVX gene are selected. See, e.g., Li, et al., 1992.  Cell  69: 915.  
      The selected cells are then injected into a blastocyst of an animal (e.g., a mouse) to form aggregation chimeras. See, e.g., Bradley, 1987. In: T ERATOCARCINOMAS AND  E MBRYONIC  S TEM  C ELLS:  A P RACTICAL  A PPROACH,  Robertson, ed. IRL, Oxford, pp. 113-152. A chimeric embryo can then be implanted into a suitable pseudopregnant female foster animal and the embryo brought to term. Progeny harboring the homologously-recombined DNA in their germ cells can be used to breed animals in which all cells of the animal contain the homologously-recombined DNA by germline transmission of the transgene. Methods for constructing homologous recombination vectors and homologous recombinant animals are described further in Bradley, 1991.  Curr. Opin. Biotechnol.  2: 823-829; PCT International Publication Nos.: WO 90/11354; WO 91/01140; WO 92/0968; and WO 93/04169.  
      In another embodiment, transgenic non-humans animals can be produced that contain selected systems that allow for regulated expression of the transgene. One example of such a system is the cre/loxP recombinase system of bacteriophage P1. For a description of the cre/loxP recombinase system, See, e.g., Lakso, et al., 1992.  Proc. Natl. Acad. Sci. USA  89: 6232-6236. Another example of a recombinase system is the FLP recombinase system of  Saccharomyces cerevisiae.  See, O&#39;Gorman, et al., 1991.  Science  251:1351-1355. If a cre/loxP recombinase system is used to regulate expression of the transgene, animals containing transgenes encoding both the Cre recombinase and a selected protein are required. Such animals can be provided through the construction of “double” transgenic animals, e.g., by mating two transgenic animals, one containing a transgene encoding a selected protein and the other containing a transgene encoding a recombinase.  
      Clones of the non-human transgenic animals described herein can also be produced according to the methods described in Wilmut, et al., 1997.  Nature  385: 810-813. In brief, a cell (e.g., a somatic cell) from the transgenic animal can be isolated and induced to exit the growth cycle and enter G 0  phase. The quiescent cell can then be fused, e.g., through. the use of electrical pulses, to an enucleated oocyte from an animal of the same species from which the quiescent cell is isolated. The reconstructed oocyte is then cultured such that it develops to morula or blastocyte and then transferred to pseudopregnant female foster animal. The offspring borne of this female foster animal will be a clone of the animal from which the cell (e.g., the somatic cell) is isolated.  
      Pharmaceutical Compositions  
      The NOVX nucleic acid molecules, NOVX proteins, and anti-NOVX antibodies (also referred to herein as “active compounds”) of the invention, and derivatives, fragments, analogs and homologs thereof, can be incorporated into pharmaceutical compositions suitable for administration. Such compositions typically comprise the nucleic acid molecule, protein, or antibody and a pharmaceutically acceptable carrier. As used herein, “pharmaceutically acceptable carrier” is intended to include any and all solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, and the like, compatible with pharmaceutical administration. Suitable carriers are described in the most recent edition of Remington&#39;s Pharmaceutical Sciences, a standard reference text in the field, which is incorporated herein by reference. Preferred examples of such carriers or diluents include, but are not limited to, water, saline, finger&#39;s solutions, dextrose solution, and 5% human serum albumin. Liposomes and non-aqueous vehicles such as fixed oils may also be used. The use of such media and agents for pharmaceutically active substances is well known in the art. Except insofar as any conventional media or agent is incompatible with the active compound, use thereof in the compositions is contemplated. Supplementary active compounds can also be incorporated into the compositions.  
      A pharmaceutical composition of the invention is formulated to be compatible with its intended route of administration. Examples of routes of administration include parenteral, e.g., intravenous, intradermal, subcutaneous, oral (e.g., inhalation), transdermal (i.e., topical), transmucosal, and rectal administration. Solutions or suspensions used for parenteral, intradermal, or subcutaneous application can include the following components: a sterile diluent such as water for injection, saline solution, fixed oils, polyethylene glycols, glycerine, propylene glycol or other synthetic solvents; antibacterial agents such as benzyl alcohol or methyl parabens; antioxidants such as ascorbic acid or sodium bisulfite; chelating agents such as ethylenediaminetetraacetic acid (EDTA); buffers such as acetates, citrates or phosphates, and agents for the adjustment of tonicity such as sodium chloride or dextrose. The pH can be adjusted with acids or bases, such as hydrochloric acid or sodium hydroxide. The parenteral preparation can be enclosed in ampoules, disposable syringes or multiple dose vials made of glass or plastic.  
      Pharmaceutical compositions suitable for injectable use include sterile aqueous solutions (where water soluble) or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersion. For intravenous administration, suitable carriers include physiological saline, bacteriostatic water, Cremophor EL™ (BASF, Parsippany, N.J.) or phosphate buffered saline (PBS). In all cases, the composition must be sterile and should be fluid to the extent that easy syringeability exists. It must be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms such as bacteria and fungi. The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), and suitable mixtures thereof. The proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants. Prevention of the action of microorganisms can be achieved by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, ascorbic acid, thimerosal, and the like. In many cases, it will be preferable to include isotonic agents, for example, sugars, polyalcohols such as manitol, sorbitol, sodium chloride in the composition. Prolonged absorption of the injectable compositions can be brought about by including in the composition an agent which delays absorption, for example, aluminum monostearate and gelatin.  
      Sterile injectable solutions can be prepared by incorporating the active compound (e.g., a NOVX protein or anti-NOVX antibody) in the required amount in an appropriate solvent with one or a combination of ingredients enumerated above, as required, followed by filtered sterilization. Generally, dispersions are prepared by incorporating the active compound into a sterile vehicle that contains a basic dispersion medium and the required other ingredients from those enumerated above. In the case of sterile powders for the preparation of sterile injectable solutions, methods of preparation are vacuum drying and freeze-drying that yields a powder of the active ingredient plus any additional desired ingredient from a previously sterile-filtered solution thereof.  
      Oral compositions generally include an inert diluent or an edible carrier. They can be enclosed in gelatin capsules or compressed into tablets. For the purpose of oral therapeutic administration, the active compound can be incorporated with excipients and used in the form of tablets, troches, or capsules. Oral compositions can also be prepared using a fluid carrier for use as a mouthwash, wherein the compound in the fluid carrier is applied orally and swished and expectorated or swallowed. Pharmaceutically compatible binding agents, and/or adjuvant materials can be included as part of the composition. The tablets, pills, capsules, troches and the like can contain any of the following ingredients, or compounds of a similar nature: a binder such as microcrystalline cellulose, gum tragacanth or gelatin; an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, or corn starch; a lubricant such as magnesium stearate or Sterotes; a glidant such as colloidal silicon dioxide; a sweetening agent such as sucrose or saccharin; or a flavoring agent such as peppermint, methyl salicylate, or orange flavoring.  
      For administration by inhalation, the compounds are delivered in the form of an aerosol spray from pressured container or dispenser which contains a suitable propellant, e.g., a gas such as carbon dioxide, or a nebulizer.  
      Systemic administration can also be by transmucosal or transdermal means. For transmucosal or transdermal administration, penetrants appropriate to the barrier to be permeated are used in the formulation. Such penetrants are generally known in the art, and include, for example, for transmucosal administration, detergents, bile salts, and fusidic acid derivatives. Transmucosal administration can be accomplished through the use of nasal sprays or suppositories. For transdermal administration, the active compounds are formulated into ointments, salves, gels, or creams as generally known in the art.  
      The compounds can also be prepared in the form of suppositories (e.g., with conventional suppository bases such as cocoa butter and other glycerides) or retention enemas for rectal delivery.  
      In one embodiment, the active compounds are prepared with carriers that will protect the compound against rapid elimination from the body, such as a controlled release formulation, including implants and microencapsulated delivery systems. Biodegradable, biocompatible polymers can be used, such as ethylene vinyl acetate, polyanhydrides, polyglycolic acid, collagen, polyorthoesters, and polylactic acid. Methods for preparation of such formulations will be apparent to those skilled in the art. The materials can also be obtained commercially from Alza Corporation and Nova Pharmaceuticals, Inc. Liposomal suspensions (including liposomes targeted to infected cells with monoclonal antibodies to viral antigens) can also be used as pharmaceutically acceptable carriers. These can be prepared according to methods known to those skilled in the art, for example, as described in U.S. Pat. No. 4,522,811.  
      It is especially advantageous to formulate oral or parenteral compositions in dosage unit form for ease of administration and uniformity of dosage. Dosage unit form as used herein refers to physically discrete units suited as unitary dosages for the subject to be treated; each unit containing a predetermined quantity of active compound calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier. The specification for the dosage unit forms of the invention are dictated by and directly dependent on the unique characteristics of the active compound and the particular therapeutic effect to be achieved, and the limitations inherent in the art of compounding such an active compound for the treatment of individuals.  
      The nucleic acid molecules of the invention can be inserted into vectors and used as gene therapy vectors. Gene therapy vectors can be delivered to a subject by, for example, intravenous injection, local administration (see, e.g., U.S. Pat. No. 5,328,470) or by stereotactic injection (see, e.g., Chen, et al., 1994.  Proc. Natl. Acad. Sci. USA  91: 3054-3057). The pharmaceutical preparation of the gene therapy vector can include the gene therapy vector in an acceptable diluent, or can comprise a slow release matrix in which the gene delivery vehicle is imbedded. Alternatively, where the complete gene delivery vector can be produced intact from recombinant cells, e.g., retroviral vectors, the pharmaceutical preparation can include one or more cells that produce the gene delivery system.  
      The pharmaceutical compositions can be included in a container, pack, or dispenser together with instructions for administration.  
      Screening and Detection Methods  
      The isolated nucleic acid molecules of the invention can be used to express NOVX protein (e.g., via a recombinant expression vector in a host cell in gene therapy applications), to detect NOVX mRNA (e.g., in a biological sample) or a genetic lesion in a NOVX gene, and to modulate NOVX activity, as described further, below. In addition, the NOVX proteins can be used to screen drugs or compounds that modulate the NOVX protein activity or expression as well as to treat disorders characterized by insufficient or excessive production of NOVX protein or production of NOVX protein forms that have decreased or aberrant activity compared to NOVX wild-type protein (e.g.; diabetes (regulates insulin release); obesity (binds and transport lipids); metabolic disturbances associated with obesity, the metabolic syndrome X as well as anorexia and wasting disorders associated with chronic diseases and various cancers, and infectious disease(possesses anti-microbial activity) and the various dyslipidemias. In addition, the anti-NOVX antibodies of the invention can be used to detect and isolate NOVX proteins and modulate NOVX activity. In yet a further aspect, the invention can be used in methods to influence appetite, absorption of nutrients and the disposition of metabolic substrates in both a positive and negative fashion.  
      The invention further pertains to novel agents identified by the screening assays described herein and uses thereof for treatments as described, supra.  
      Screening Assays  
      The invention provides a method (also referred to herein as a “screening assay”) for identifying modulators, i.e., candidate or test compounds or agents (e.g., peptides, peptidomimetics, small molecules or other drugs) that bind to NOVX proteins or have a stimulatory or inhibitory effect on, e.g., NOVX protein expression or NOVX protein activity. The invention also includes compounds identified in the screening assays described herein.  
      In one embodiment, the invention provides assays for screening candidate or test compounds which bind to or modulate the activity of the membrane-bound form of a NOVX protein or polypeptide or biologically-active portion thereof. The test compounds of the invention can be obtained using any of the numerous approaches in combinatorial library methods known in the art, including: biological libraries; spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring deconvolution; the “one-bead one-compound” library method; and synthetic library methods using affinity chromatography selection. The biological library approach is limited to peptide libraries, while the other four approaches are applicable to peptide, non-peptide oligomer or small molecule libraries of compounds. See, e.g., Lam, 1997.  Anticancer Drug Design  12: 145.  
      A “small molecule” as used herein, is meant to refer to a composition that has a molecular weight of less than about 5 kD and most preferably less than about 4 kD. Small molecules can be, e.g., nucleic acids, peptides, polypeptides, peptidomimetics, carbohydrates, lipids or other organic or inorganic molecules. Libraries of chemical and/or biological mixtures, such as fungal, bacterial, or algal extracts, are klown in the art and can be screened with any of the assays of the invention.  
      Examples of methods for the synthesis of molecular libraries can be found in the art, for example in: DeWitt, et al., 1993.  Proc. Natl. Acad. Sci. U.S.A.  90: 6909; Erb, et al., 1994.  Proc. Natl. Acad. Sci. U.S.A.  91: 11422; Zuckermann, et al., 1994.  J. Med. Chem.  37: 2678; Cho, et al., 1993.  Science  261: 1303; Carrell, et al., 1994.  Angew. Chem. Int. Ed. Engl.  33: 2059; Carell, et al., 1994.  Angew. Chem. Int. Ed. Engl.  33: 2061; and Gallop, et al., 1994.  J. Med. Chem.  37: 1233.  
      Libraries of compounds may be presented in solution (e.g., Houghten, 1992.  Biotechniques  13: 412421), or on beads (Lam, 1991.  Nature  354: 82-84), on chips (Fodor, 1993.  Nature  364: 555-556), bacteria (Ladner, U.S. Pat. No. 5,223,409), spores (Ladner, U.S. Pat. No. 5,233,409), plasmids (Cull, et al., 1992.  Proc. Natl. Acad. Sci. USA  89: 1865-1869) or on phage (Scott and Smith, 1990.  Science  249: 386-390; Devlin, 1990.  Science  249: 404-406; Cwirla, et al., 1990.  Proc. Natl. Acad. Sci. U.S.A.  87: 6378-6382; Felici, 1991.  J. Mol. Biol.  222: 301-310; Ladner, U.S. Pat. No. 5,233,409.).  
      In one embodiment, an assay is a cell-based assay in which a cell which expresses a membrane-bound form of NOVX protein, or atbiologically-active portion thereof, on the cell surface is contacted with a test compound and the ability of the test compound to bind to a NOVX protein determined. The cell, for example, can of mammalian origin or a yeast cell. Determining the ability of the test compound to bind to the NOVX protein can be accomplished, for example, by coupling the test compound with a radioisotope or enzymatic label such that binding of the test compound to the NOVX protein or biologically-active portion thereof can be determined by detecting the labeled compound in a complex. For example, test compounds can be labeled with 1251,  35 S,  14 C, or  3 H, either directly or indirectly, and the radioisotope detected by direct counting of radioemission or by scintillation counting. Alternatively, test compounds can be enzymatically-labeled with, for example, horseradish peroxidase, alkaline phosphatase, or luciferase, and the enzymatic label detected by determination of conversion of an appropriate substrate to product. In one embodiment, the assay comprises contacting a cell which expresses a membrane-bound form of NOVX protein, or a biologically-active portion thereof, on the cell surface with a known compound which binds NOVX to form an assay mixture, contacting the assay mixture with a test compound, and determining the ability of the test compound to interact with a NOVX protein, wherein determining the ability of the test compound to interact with a NOVX protein comprises determining the ability of the test compound to preferentially bind to NOVX protein or a biologically-active portion thereof as compared to the known compound.  
      In another embodiment, an assay is a cell-based assay comprising contacting a cell expressing a membrane-bound form of NOVX protein, or a biologically-active portion thereof, on the cell surface with a test compound and determining the ability of the test compound to modulate (e.g., stimulate or inhibit) the activity of the NOVX protein or biologically-active portion thereof. Determining the ability of the test compound to modulate the activity of NOVX or a biologically-active portion thereof can be accomplished, for example, by determining the ability of the NOVX protein to bind to or interact with a NOVX target molecule. As used herein, a “target molecule” is a molecule with which a NOVX protein binds or interacts in nature, for example, a molecule on the surface of a cell which expresses a NOVX interacting protein, a molecule on the surface of a second cell, a molecule in the extracellular milieu, a molecule associated with the internal surface of a cell membrane or a cytoplasmic molecule. A NOVX target molecule can be a non-NOVX molecule or a NOVX protein or polypeptide of the invention. In one embodiment, a NOVX target molecule is a component of a signal transduction pathway that facilitates transduction of an extracellular signal (e.g. a signal generated by binding of a compound to a membrane-bound NOVX molecule) through the cell membrane and into the cell. The target, for example, can be a second intercellular protein that has catalytic activity or a protein that facilitates the association of downstream signaling molecules with NOVX.  
      Determining the ability of the NOVX protein to bind to or interact with a NOVX target molecule can be accomplished by one of the methods described above for determining direct binding. In one embodiment, determining the ability of the NOVX protein to bind to or interact with a NOVX target molecule can be accomplished by determining the activity of the target molecule. For example, the activity of the target molecule can be determined by detecting induction of a cellular second messenger of the target (i.e. intracellular Ca 2+ , diacylglycerol, IP 3 , etc.), detecting catalytic/enzymatic activity of the target an appropriate substrate, detecting the induction of a reporter gene (comprising a NOVX-responsive regulatory element operatively linked to a nucleic acid encoding a detectable marker, e.g., luciferase), or detecting a cellular response, for example, cell survival, cellular differentiation, or cell proliferation.  
      In yet another embodiment, an assay of the invention is a cell-free assay comprising contacting a NOVX protein or biologically-active portion thereof with a test compound and determining the ability of the test compound to bind to the NOVX protein or biologically-active portion thereof. Binding of the test compound to the NOVX protein can be determined either directly or indirectly as described above. In one such embodiment, the assay comprises contacting the NOVX protein or biologically-active portion thereof with a known compound which binds NOVX to form an assay mixture, contacting the assay mixture with a test compound, and determining the ability of the test compound to interact with a NOVX protein, wherein determining the ability of the test compound to interact with a NOVX protein comprises determining the ability of the test compound to preferentially bind to NOVX or biologically-active portion thereof as compared to the known compound.  
      In still another embodiment, an assay is a cell-free assay comprising contacting NOVX protein or biologically-active portion thereof with a test compound and determining the ability of the test compound to modulate (e.g. stimulate or inhibit) the activity of the NOVX protein or biologically-active portion thereof. Determining the ability of the test compound to modulate the activity of NOVX can be accomplished, for example, by determining the ability of the NOVX protein to bind to a NOVX target molecule by one of the methods described above for determining direct binding. In an alternative embodiment, determining the ability of the test compound to modulate the activity of NOVX protein can be accomplished by determining the ability of the NOVX protein further modulate a NOVX target molecule. For example, the catalytic/enzymatic activity of the target molecule on an appropriate substrate can be determined as described, supra.  
      In yet another embodiment, the cell-free assay comprises contacting the NOVX protein or biologically-active portion thereof with a known compound which binds NOVX protein to form an assay mixture, contacting the assay mixture with a test compound, and determining the ability of the test compound to interact with a NOVX protein, wherein determining the ability of the test compound to interact with a NOVX protein comprises determining the ability of the NOVX protein to preferentially bind to or modulate the activity of a NOVX target molecule.  
      The cell-free assays of the invention are amenable to use of both the soluble form or the membrane-bound form of NOVX protein. In the case of cell-free assays comprising the membrane-bound form of NOVX protein, it may be desirable to utilize a solubilizing agent such that the membrane-bound form of NOVX protein is maintained in solution. Examples of such solubilizing agents include non-ionic detergents such as n-octylglucoside, n-dodecylglucoside, n-dodecylmaltoside, octanoyl-N-methylglucaamide, decanoyl-N-methylglucarnide, Triton® X-100, Triton® X-114, Thesit®, Isotridecypoly(ethylene glycol ether) n , N-dodecyl--N,N-dimethyl-3-ammonio-1-propane sulfonate, 3-(3-cholamidopropyl) dimethylamminiol-1-propane sulfonate (CHAPS), or 3-(3-cholamidopropyl)dimethylarmniniol-2-hydroxy-1-propane sulfonate (CHAPSO).  
      In more than one embodiment of the above assay methods of the invention, it may be desirable to immobilize either NOVX protein or its target molecule to facilitate separation of complexed from uncomplexed forms of one or both of the proteins, as well as to accommodate automation of the assay. Binding of a test compound to NOVX protein, or interaction of NOVX protein with a target molecule in the presence and absence of a candidate compound, can be accomplished in any vessel suitable for containing the reactants. Examples of such vessels include microtiter plates, test tubes, and micro-centrifuge tubes. In one embodiment, a fusion protein can be provided that adds a domain that allows one or both of the proteins to be bound to a matrix. For example, GST-NOVX fusion proteins or GST-target fusion proteins can be adsorbed onto glutathione sepharose beads (Sigma Chemical, St. Louis, Mo.) or glutathione derivatized microtiter plates, that are then combined with the test compound or the test compound and either the non-adsorbed target protein or NOVX protein, and the mixture is incubated under conditions conducive to complex formation (e.g., at physiological conditions for salt and pH). Following incubation, the beads or microtiter plate wells are washed to remove any unbound components, the matrix immobilized in the case of beads, complex determined either directly or indirectly, for example, as described, supra. Alternatively, the complexes can be dissociated from the matrix, and the level of NOVX protein binding or activity determined using standard techniques.  
      Other techniques for immobilizing proteins on matrices can also be used in the screening assays of the invention. For example, either the NOVX protein or its target molecule can be immobilized utilizing conjugation of biotin and streptavidin. Biotinylated NOVX protein or target molecules can be prepared from biotin-NHS (N-hydroxy-succinimide) using techniques well-known within the art (e.g., biotinylation kit, Pierce Chemicals, Rockford, Ill.), and immobilized in the wells of streptavidin-coated 96 well plates (Pierce Chemical). Alternatively, antibodies reactive with NOVX protein or target molecules, but which do not interfere with binding of the NOVX protein to its target molecule, can be derivatized to the wells of the plate, and unbound target or NOVX protein trapped in the wells by antibody conjugation. Methods for detecting such complexes, in addition to those described above for the GST-immobilized complexes, include immunodetection of complexes using antibodies reactive with the NOVX protein or target molecule, as well as enzyme-linked assays that rely on detecting an enzymatic activity associated with the NOVX protein or target molecule.  
      In another embodiment, modulators of NOVX protein expression are identified in a method wherein a cell is contacted with a candidate compound and the expression of NOVX mRNA or protein in the cell is determined. The level of expression of NOVX mRNA or protein in the presence of the candidate compound is compared to the level of expression of NOVX mRNA or protein in the absence of the candidate compound. The candidate compound can then be identified as a modulator of NOVX mRNA or protein expression based upon this comparison. For example, when expression of NOVX mRNA or protein is greater (i.e., statistically significantly greater) in the presence of the candidate compound than in its absence, the candidate compound is identified as a stimulator of NOVX mRNA or protein expression. Alternatively, when expression of NOVX rnRNA or protein is less (statistically significantly less) in the presence of the candidate compound than in its absence, the candidate compound is identified as an inhibitor of NOVX mRNA or protein expression. The level of NOVX mRNA or protein expression in the cells can be determined by methods described herein for detecting NOVX mRNA or protein.  
      In yet another aspect of the invention, the NOVX proteins can be used as “bait proteins” in a two-hybrid assay or three hybrid assay (see, e.g., U.S. Pat. No. 5,283,317; Zervos, et al., 1993.  Cell  72: 223-232; Madura, et al., 1993.  J. Biol. Chem.  268: 12046-12054; Bartel, et al., 1993.  Biotechniques  14: 920-924; Iwabuchi, et al., 1993.  Oncogene  8: 1693-1696; and Brent WO 94/10300), to identify other proteins that bind to or interact with NOVX (“NOVX-binding proteins” or “NOVX-bp”) and modulate NOVX activity. Such NOVX-binding proteins are also involved in the propagation of signals by the NOVX proteins as, for example, upstream or downstream elements of the NOVX pathway.  
      The two-hybrid system is based on the modular nature of most transcription factors, which consist of separable DNA-binding and activation domains. Briefly, the assay utilizes two different DNA constructs. In one construct, the gene that codes for NOVX is fused to a gene encoding the DNA binding domain of a known transcription factor (e.g., GAL-4). In the other construct, a DNA sequence, from a library of DNA sequences, that encodes an unidentified protein (“prey” or “sample”) is fused to a gene that codes for the activation domain of the known transcription factor. If the “bait” and the “prey” proteins are able to interact, in vivo, forming a NOVX-dependent complex, the DNA-binding and activation domains of the transcription factor are brought into close proximity. This proximity allows transcription of a reporter gene (e.g., LacZ) that is operably linked to a transcriptional regulatory site responsive to the transcription factor. Expression of the reporter gene can be detected and cell colonies containing the functional transcription factor can be isolated and used to obtain the cloned gene that encodes the protein which interacts with NOVX.  
      The invention further pertains to novel agents identified by the aforementioned screening assays and uses thereof for treatments as described herein.  
      Detection Assays  
      Portions or fragments of the cDNA sequences identified herein (and the corresponding complete gene sequences) can be used in numerous ways as polynucleotide reagents. By way of example, and not of limitation, these sequences can be used to: (i) map their respective genes on a chromosome; and, thus, locate gene regions associated with genetic disease; (ii) identify an individual from a minute biological sample (tissue typing); and (iii) aid in forensic identification of a biological sample. Some of these applications are described in the subsections, below.  
      Chromosome Mapping  
      Once the sequence (or a portion of the sequence) of a gene has been isolated, this sequence can be used to map the location of the gene on a chromosome. This process is called chromosome mapping. Accordingly, portions or fragments of the NOVX sequences of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, or fragments or derivatives thereof, can be used to map the location of the NOVX genes, respectively, on a chromosome. The mapping of the NOVX sequences to chromosomes is an important first step in correlating these sequences with genes associated with disease.  
      Briefly, NOVX genes can be mapped to chromosomes by preparing PCR primers (preferably 15-25 bp in length) from the NOVX sequences. Computer analysis of the NOVX, sequences can be used to rapidly select primers that do not span more than one exon in the genomic DNA, thus complicating the amplification process. These primers can then be used for PCR screening of somatic cell hybrids containing individual human chromosomes. Only those hybrids containing the human gene corresponding to the NOVX sequences will yield an amplified fragment.  
      Somatic cell hybrids are prepared by fusing somatic cells from different mammals (e.g., human and mouse cells). As hybrids of human and mouse cells grow and divide, they gradually lose human chromosomes in random order, but retain the mouse chromosomes. By using media in which mouse cells cannot grow, because they lack a particular enzyme, but in which human cells can, the one human chromosome that contains the gene encoding the needed enzyme will be retained. By using various media, panels of hybrid cell lines can be established. Each cell line in a panel contains either a single human chromosome or a small number of human chromosomes, and a full set of mouse chromosomes, allowing easy mapping of individual genes to specific human chromosomes. See, e.g., D&#39;Eustachio, et al., 1983.  Science  220: 919-924. Somatic cell hybrids containing only fragments of human chromosomes can also be produced by using human chromosomes with translocations and deletions.  
      PCR mapping of somatic cell hybrids is a rapid procedure for assigning a particular sequence to a particular chromosome. Three or more sequences can be assigned per day using a single thermal cycler. Using the NOVX sequences to design oligonucleotide primers, sub-localization can be achieved with panels of fragments from specific chromosomes.  
      Fluorescence in situ hybridization (FISH) of a DNA sequence to a metaphase chromosomal spread can further be used to provide a precise chromosomal location in one step. Chromosome spreads can be made using cells whose division has been blocked in metaphase by a chemical like colcemid that disrupts the mitotic spindle. The chromosomes can be treated briefly with trypsin, and then stained with Giemsa. A pattern of light and dark bands develops on each chromosome, so that the chromosomes can be identified individually. The FISH technique can be used with a DNA sequence as short as 500 or 600 bases. However, clones larger than 1,000 bases have a higher likelihood of binding to a unique chromosomal location with sufficient signal intensity for simple detection. Preferably 1,000 bases, and more preferably 2,000 bases, will suffice to get good results at a reasonable amount of time. For a review of this technique, see, Verma, et al., H UMAN  C HROMOSOMES:  A M ANUAL OF  B ASIC  T ECHNIQUES  (Pergamon Press, New York 1988).  
      Reagents for chromosome mapping can be used individually to mark a single chromosome or a single site on that chromosome, or panels of reagents can be used for marking multiple sites and/or multiple chromosomes. Reagents corresponding to noncoding regions of the genes actually are preferred for mapping purposes. Coding sequences are more likely to be conserved within gene families, thus increasing the chance of cross hybridizations during chromosomal mapping.  
      Once a sequence has been mapped to a precise chromosomal location, the physical position of the sequence on the chromosome can be correlated with genetic map data. Such data are found, e.g., in McKusick, M ENDELIAN  I NERIANCE IN  M AN,  available on-line through Johns Hopkins University Welch Medical Library). The relationship between genes and disease, mapped to the same chromosomal region, can then be identified through linkage analysis (co-inheritance of physically adjacent genes), described in, e.g., Egeland, et al., 1987.  Nature,  325: 783-787.  
      Moreover, differences in the DNA sequences between individuals affected and unaffected with a disease associated with the NOVX gene, can be determined. If a mutation is observed in some or all of the affected individuals but not in any unaffected individuals, then the mutation is likely to be the causative agent of the particular disease. Comparison of affected and unaffected individuals generally involves first looking for structural alterations in the chromosomes, such as deletions or translocations that are visible from chromosome spreads or detectable using PCR based on that DNA sequence. Ultimately, complete sequencing of genes from several individuals can be performed to confirm the presence of a mutation and to distinguish mutations from polymorphisms.  
      Tissue Typing  
      The NOVX sequences of the invention can also be used to identify individuals from minute biological samples. In this technique, an individual&#39;s genomic DNA is digested with one or more restriction enzymes, and probed on a Southern blot to yield unique bands for identification. The sequences of the invention are useful as additional DNA markers for RFLP (“restriction fragment length polymorphisms,” described in U.S. Pat. No. 5,272,057).  
      Furthermore, the sequences of the invention can be used to provide an alternative technique that determines the actual base-by-base DNA sequence of selected portions of an individual&#39;s genome. Thus, the NOVX sequences described herein can be used to prepare two PCR primers from the 5′- and 3′-termini of the sequences. These primers can then be used to amplify an individual&#39;s DNA and subsequently sequence it.  
      Panels of corresponding DNA sequences from individuals, prepared in this manner, can provide unique individual identifications, as each individual will have a unique set of such DNA sequences due to allelic differences. The sequences of the invention can be used to obtain such identification sequences from individuals and from tissue. The NOVX sequences of the invention uniquely represent portions of the human genome. Allelic variation occurs to some degree in the coding regions of these sequences, and to a greater degree in the noncoding regions. It is estimated that allelic variation between individual humans occurs with a frequency of about once per each 500 bases. Much of the allelic variation is due to single nucleotide polymorphisms (SNPs), which include restriction fragment length polymorphisms (RFLts).  
      Each of the sequences described herein can, to some degree, be used as a standard against which DNA from an individual can be compared for identification purposes. Because greater numbers of polymorphisms occur in the noncoding regions, fewer sequences are necessary to differentiate individuals. The noncoding sequences can comfortably provide positive individual identification with a panel of perhaps 10 to 1,000 primers that each yield a noncoding amplified sequence of 100 bases. If coding sequences, such as those of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, are used, a more appropriate number of primers for positive individual identification would be 500-2,000.  
      Predictive Medicine  
      The invention also pertains to the field of predictive medicine in which diagnostic assays, prognostic assays, pharmacogenomics, and monitoring clinical trials are used for prognostic (predictive) purposes to thereby treat an individual prophylactically. Accordingly, one aspect of the invention relates to diagnostic assays for determining NOVX protein and/or nucleic acid expression as well as NOVX activity, in the context of a biological sample (e.g., blood, serum, cells, tissue) to thereby determine whether an individual is afflicted with a disease or disorder, or is at risk of developing a disorder, associated with aberrant NOVX expression or activity. The disorders include metabolic disorders, diabetes, obesity, infectious disease, anorexia, cancer-associated cachexia, cancer, neurodegenerative disorders, Alzheimer&#39;s Disease, Parkinson&#39;s Disorder, immune disorders, and hematopoietic disorders, and the various dyslipidemias, metabolic disturbances associated with obesity, the metabolic syndrome X and wasting disorders associated with chronic diseases and various cancers. The invention also provides for prognostic (or predictive) assays for determining whether an individual is at risk of developing a disorder associated with NOVX protein, nucleic acid expression or activity. For example, mutations in a NOVX gene can be assayed in a biological sample. Such assays can be used for prognostic or predictive purpose to thereby prophylactically treat an individual prior to the onset of a disorder characterized by or associated with NOVX protein, nucleic acid expression, or biological activity.  
      Another aspect of the invention provides methods for determining NOVX protein, nucleic acid expression or activity in an individual to thereby select appropriate therapeutic or prophylactic agents for that individual (referred to herein as “pharmacogenomics”). Pharmacogenomics allows for the selection of agents (e.g., drugs) for therapeutic or prophylactic treatment of an individual based on the genotype of the individual (e.g., the genotype of the individual examined to determine the ability of the individual to respond to a particular agent.) Yet another aspect of the invention pertains to monitoring the influence of agents (e.g., drugs, compounds) on the expression or activity of NOVX in clinical trials.  
      These and other agents are described in further detail in the following sections.  
      Diagnostic Assays  
      An exemplary method for detecting the presence or absence of NOVX in a biological sample involves obtaining a biological sample from a test subject and contacting the biological sample with a compound or an agent capable of detecting NOVX protein or nucleic acid (e.g., mRNA, genomic DNA) that encodes NOVX protein such that the presence of NOVX is detected in the biological sample. An agent for detecting NOVX rnRNA or genomic DNA is a labeled nucleic acid probe capable of hybridizing to NOVX mRNA or genomic DNA. The nucleic acid probe can be, for example, a full-length NOVX nucleic acid, such as the nucleic acid of SEQ ID NO:2n−1, wherein n is an integer between 1 and 606, or a portion thereof, such as an oligonucleotide of at least 15, 30, 50, 100, 250 or 500 nucleotides in length and sufficient to specifically hybridize under stringent conditions to NOVX mRNA or genomic DNA. Other suitable probes for use in the diagnostic assays of the invention are described herein.  
      An agent for detecting NOVX protein is an antibody capable of binding to NOVX protein, preferably an antibody with a detectable label. Antibodies can be polyclonal, or more preferably, monoclonal. An intact antibody, or a fragment thereof (e.g., Fab or F(ab′) 2 ) can be used. The term “labeled”, with regard to the probe or antibody, is intended to encompass direct labeling of the probe or antibody by coupling (i.e., physically linking) a detectable substance to the probe or antibody, as well as indirect labeling of the probe or antibody by reactivity with another reagent that is directly labeled. Examples of indirect labeling include detection of a primary antibody using a fluorescently-labeled secondary antibody and end-labeling of a DNA probe with biotin such that it can be detected with flucrescently-labeled streptavidin. The term “biological sample” is intended to include tissues, cells and biological fluids isolated from a subject, as well as tissues, cells and fluids present within a subject. That is, the detection method of the invention can be used to detect NOVX mRNA, protein, or genomic DNA in a biological sample in vitro as well as in vivo. For example, in vitro techniques for detection of NOVX mRNA include Northern hybridizations and in situ hybridizations. In vitro techniques for detection of NOVX protein include enzyme linked immunosorbent assays (ELISAs), Western blots, immunoprecipitations, and immunofluorescence. In vitro techniques for detection of NOVX genomic DNA include Southern hybridizations. Furthermore, in vivo techniques for detection of NOVX protein include introducing into a subject a labeled anti-NOVX antibody. For example, the antibody can be labeled with a radioactive marker whose presence and location in a subject can be detected by standard imaging techniques.  
      In one embodiment, the biological sample contains protein molecules from the test subject. Alternatively, the biological sample can contain mRNA molecules from the test subject or genomic DNA molecules from the test subject. A preferred biological sample is a peripheral blood leukocyte sample isolated by conventional means from a subject.  
      In another embodiment, the methods further involve obtaining a control biological sample from a control subject, contacting the control sample with a compound or agent capable of detecting NOVX protein, mRNA, or genomic DNA, such that the presence of NOVX protein, mRNA or genomic DNA is detected in the biological sample, and comparing the presence of NOVX protein, mRNA or genornic DNA in the control sample with the presence of NOVX protein, mRNA or genomic DNA in the test sample.  
      The invention also encompasses kits for detecting the presence of NOVX in a biological sample. For example, the kit can comprise: a labeled compound or agent capable of detecting NOVX protein or mRNA in a biological sample; means for T determining the amount of NOVX in the sample; and means for comparing the amount of NOVX in the sample with a standard. The compound or agent can be packaged in a suitable container. The kit can further comprise instructions for using the kit to detect NOVX protein or nucleic acid.  
      Prognostic Assays  
      The diagnostic methods described herein can furthermore be utilized to identify subjects having or at risk of developing a disease or disorder associated with aberrant NOVX expression or activity. For example, the assays described herein, such as the preceding diagnostic assays or the following assays, can be utilized to identify a subject having or at risk of developing a disorder associated with NOVX protein, nucleic acid expression or activity. Alternatively, the prognostic assays can be utilized to identify a subject having or at risk for developing a disease or disorder. Thus, the invention provides a method for identifying a disease or disorder associated with aberrant NOVX expression or activity in which a test sample is obtained from a subject and NOVX protein or nucleic acid (e.g., mRNA, genornic DNA) is detected, wherein the presence of NOVX protein or nucleic acid is diagnostic for a subject having or at risk of developing a disease or disorder associated with aberrant NOVX expression or activity. As used herein, a “test sample” refers to a biological sample obtained from a subject of interest. For example, a test sample can be a biological fluid (e.g., serum), cell sample, or tissue.  
      Furthermore, the prognostic assays described herein can be used to determine whether a subject can be administered an agent (e.g., an agonist, antagonist, peptidomimetic, protein, peptide, nucleic acid, small molecule, or other drug candidate) to treat a disease or disorder associated with aberrant NOVX expression or activity. For example, such methods can be used to determine whether a subject can be effectively treated with an agent for a disorder. Thus, the invention provides methods for determining whether a subject can be effectively treated with an agent for a disorder associated with aberrant NOVX expression or activity in which a test sample is obtained and NOVX protein or nucleic acid is detected (e.g., wherein the presence of NOVX protein or nucleic acid is diagnostic for a subject that can be administered the agent to treat a disorder associated with aberrant NOVX expression or activity).  
      The methods of the invention can also be used to detect genetic lesions in a NOVX gene, thereby determining if a subject with the lesioned gene is at risk for a disorder characterized by aberrant cell proliferation and/or differentiation. In various embodiments, the methods include detecting, in a sample of cells from the subject, the presence or absence of a genetic lesion characterized by at least one of an alteration affecting the integrity of a gene encoding a NOVX-protein, or the misexpression of the NOVX gene. For example, such genetic lesions can be detected by ascertaining the existence of at least one of: (i) a deletion of one or more nucleotides from a NOVX gene; (ii) an addition of one or more nucleotides to a NOVX gene; (iii) a substitution of one or more nucleotides of a NOVX gene, (iv) a chromosomal rearrangement of a NOVX gene; (v) an alteration in the level of a messenger RNA transcript of a NOVX gene, (vi) aberrant modification of a NOVX gene, such as of the methylation pattern of the genomic DNA, (vii) the presence of a non-wild-type splicing pattern of a messenger RNA transcript of a NOVX gene, (viii) a non-wild-type level of a NOVX protein, (ix) allelic loss of a NOVX gene, and (x) inappropriate post-translational modification of a NOVX protein. As described herein, there are a large number of assay techniques known in the art which can be used for detecting lesions in a NOVX gene. A preferred biological sample is a peripheral blood leukocyte sample isolated by conventional means from a subject. However, any biological sample containing nucleated cells may be used, including, for example, buccal mucosal cells.  
      In certain embodiments, detection of the lesion involves the use of a probe/primer in a polymerase chain reaction (PCR) (see, e.g., U.S. Pat. Nos. 4,683,195 and 4,683,202), such as anchor PCR or RACE PCR, or, alternatively, in a ligation chain reaction (LCR) (see, e.g., Landegran, et al., 1988.  Science  241: 1077-1080; and Nakazawa, et al., 1994.  Proc. Natl. Acad. Sci. USA  91: 360-364), the latter of which can be particularly useful for detecting point mutations in the NOVX-gene (see, Abravaya, et al., 1995.  Nucl. Acids Res.  23: 675-682). This method can include the steps of collecting a sample of cells from a patient, isolating nucleic acid (e.g., genomic, mRNA or both) from the cells of the sample, contacting the nucleic acid sample with one or more primers that specifically hybridize to a NOVX gene under conditions such that hybridization and amplification of the NOVX gene (if present) occurs, and detecting the presence or absence of an amplification product, or detecting the size of the amplification product and comparing the length to a control sample. It is anticipated that PCR and/or LCR may be desirable to use as a preliminary amplification step in conjunction with any of the techniques used for detecting mutations described herein.  
      Alternative amplification methods include: self sustained sequence replication (see, Guatelli, et al., 1990.  Proc. Natl. Acad. Sci. USA  87: 1874-1878), transcriptional amplification system (see, Kwoh, et al., 1989.  Proc. Natl. Acad. Sci. USA  86: 1173-1177); Qβ Replicase (see, Lizardi, et al, 1988.  BioTechnology  6: 1197), or any other nucleic acid amplification method, followed by the detection of the amplified molecules using techniques well known to those of skill in the art. These detection schemes are especially useful for the detection of nucleic acid molecules if such molecules are present in very low numbers.  
      In an alternative embodiment, mutations in a NOVX gene from a sample cell can be identified by alterations in restriction enzyme cleavage patterns. For example, sample and control DNA is isolated, amplified (optionally), digested with one or more restriction endonucleases, and fragment length sizes are determined by gel electrophoresis and compared. Differences in fragment length sizes between sample and control DNA indicates mutations in the sample DNA. Moreover, the use of sequence specific ribozymes (see, e.g., U.S. Pat. No. 5,493,531) can be used to score for the presence of specific mutations by development or loss of a ribozyme cleavage site.  
      In other embodiments, genetic mutations in NOVX can be identified by hybridizing a sample and control nucleic acids, e.g., DNA or RNA, to high-density arrays containing hundreds or thousands of oligonucleotides probes. See, e.g., Cronin, et al., 1996.  Human Mutation  7: 244-255; Kozal, et al., 1996.  Nat. Med.  2: 753-759. For example, genetic mutations in NOVX can be identified in two dimensional arrays containing light-generated DNA probes as described in Cronin, et al., supra. Briefly, a first hybridization array of probes can be used to scan through long stretches of DNA in a sample and control to identify base changes between the sequences by making linear arrays of sequential overlapping probes. This step allows the identification of point mutations. This is followed by a second hybridization array that allows the characterization of specific mutations by using smaller, specialized probe arrays complementary to all variants or mutations detected. Each mutation array is composed of parallel probe sets, one complementary to the wild-type gene and the other complementary to the mutant gene.  
      In yet another embodiment, any of a variety of sequencing reactions known in the art can be used to directly sequence the NOVX gene and detect mutations by comparing the sequence of the sample NOVX with the corresponding wild-type (control) sequence. Examples of sequencing reactions include those based on techniques developed by Maxim and Gilbert, 1977.  Proc. Natl. Acad. Sci. USA  74: 560 or Sanger, 1977.  Proc. Natl. Acad. Sci. USA  74: 5463. It is also contemplated that any of a variety of automated sequencing procedures can be utilized when performing the diagnostic assays (see, e.g., Naeve, et al., 1995.  Biotechniques  19: 448), including sequencing by mass spectrometry (see, e.g., PCT International Publication No. WO 94/16101; Cohen, et al., 1996.  Adv. Chromatography  36: 127-162; and Griffin, et al., 1993.  Appl. Biochem. Biotechnol.  38: 147-159).  
      Other methods for detecting mutations in the NOVX gene include methods in which protection from cleavage agents is used to detect mismatched bases in RNA/RNA or RNA/DNA heteroduplexes. See, e.g., Myers, et al., 1985.  Science  230: 1242. In general, the art technique of “mismatch cleavage” starts by providing heteroduplexes of formed by hybridizing (labeled) RNA or DNA containing the wild-type NOVX sequence with potentially mutant RNA or DNA obtained from a tissue sample. The double-stranded duplexes are treated with an agent that cleaves single-stranded regions of the duplex such as which will exist due to basepair mismatches between the control and sample strands. For instance, RNA/DNA duplexes can be treated with RNase and DNA/DNA hybrids treated with SI nuclease to enzymatically digesting the mismatched regions. In other embodiments, either DNA/DNA or RNA/DNA duplexes can be treated with hydroxylamine or osmium tetroxide and with piperidine in order to digest mismatched regions. After digestion of the mismatched regions, the resulting material is then separated by size on denaturing polyacrylamide gels to determine the site of mutation. See, e.g., Cotton, et al., 1988.  Proc. Natl. Acad. Sci. USA  85: 4397; Saleeba, et al., 1992.  Methods Enzymol.  217: 286-295. In an embodiment, the control DNA or RNA can be labeled for detection.  
      In still another embodiment, the mismatch cleavage reaction employs one or more proteins that recognize mismatched base pairs in double-stranded DNA (so called “DNA mismatch repair” enzymes) in defined systems for detecting and mapping point mutations in NOVX cDNAs obtained from samples of cells. For example, the mutY enzyme of  E. coli  cleaves A at G/A mismatches and the thymidine DNA glycosylase from HeLa cells cleaves T at G/T mismatches. See, e.g., Hsu, et al., 1994.  Carcinogenesis  15: 1657-1662. According to an exemplary embodiment, a probe based on a NOVX sequence, e.g., a wild-type NOVX sequence, is hybridized to a cDNA or other DNA product from a test cell(s). The duplex is treated with a DNA mismatch repair enzyme, and the cleavage products, if any, can be detected from electrophoresis protocols or the like. See, e.g., U.S. Pat. No. 5,459,039.  
      In other embodiments, alterations in electrophoretic mobility will be used to identify mutations in NOVX genes. For example, single strand conformation polymorphism (SSCP) may be used to detect differences in electrophoretic mobility between mutant and wild type nucleic acids. See, e.g., Orita, et al., 1989.  Proc. Natl. Acad. Sci. USA:  86: 2766; Cotton, 1993.  Mutat. Res.  285: 125-144; Hayashi, 1992.  Genet. Anal. Tech. Appl.  9: 73-79. Single-stranded DNA fragments of sample and control NOVX nucleic acids will be denatured and allowed to renature. The secondary structure of single-stranded nucleic acids varies according to sequence, the resulting alteration in electrophoretic mobility enables the detection of even a single base change. The DNA fragments may be labeled or detected with labeled probes. The sensitivity of the assay may be enhanced by using RNA (rather than DNA), in which the secondary structure is more sensitive to a change in sequence. In one embodiment, the subject method utilizes heteroduplex analysis to separate double stranded heteroduplex molecules on the basis of changes in electrophoretic mobility. See, e.g., Keen, et al., 1991.  Trends Genet.  7: 5.  
      In yet another embodiment, the movement of mutant or wild-type fragments in polyacrylamide gels containing a gradient of denaturant is assayed using denaturing gradient gel electrophoresis (DGGE). See, e.g., Myers, et al., 1985.  Nature  313: 495. When DGGE is used as the method of analysis, DNA will be modified to insure that it does not completely denature, for example by adding a GC clamp of approximately 40 bp of high-melting GC-rich DNA by PCR. In a further embodiment, a temperature gradient is used in place of a denaturing gradient to identify differences in the mobility of control and sample DNA. See, e.g., Rosenbaum and Reissner, 1987.  Biophys. Chem.  265: 12753.  
      Examples of other techniques for detecting point mutations include, but are not limited to, selective oligonucleotide hybridization, selective amplification, or selective primer extension. For example, oligonucleotide primers may be prepared in which the known mutation is placed centrally and then hybridized to target DNA under conditions that permit hybridization only if a perfect match is found. See, e.g., Saiki, et al., 1986.  Nature  324: 163; Saiki, et al., 1989.  Proc. Natl. Acad. Sci. USA  86: 6230. Such allele specific oligonucleotides are hybridized to PCR amplified target DNA or a number of different mutations when the oligonucleotides are attached to the hybridizing membrane and hybridized with labeled target DNA.  
      Alternatively, allele specific amplification technology that depends on selective PCR amplification may be used in conjunction with the instant invention. Oligonucleotides used as primers for specific amplification may carry the mutation of interest in the center of the molecule (so that amplification depends on differential hybridization; see, e.g., Gibbs, et al., 1989.  Nucl. Acids Res.  17: 2437-2448) or at the extreme 3′-terminus of one primer where, under appropriate conditions, mismatch can prevent, or reduce polymerase extension (see, e.g., Prossner, 1993.  Tibtech.  11: 238). In addition it may be desirable to introduce a novel restriction site in the region of the mutation to create cleavage-based detection. See, e.g., Gasparini, et al., 1992.  Mol. Cell Probes  6: 1. It is anticipated that in certain embodiments amplification may also be performed using Taq ligase for amplification. See, e.g., Barany, 1991.  Proc. Natl. Acad. Sci. USA  88: 189. In such cases, ligation will occur only if there is a perfect match at the 3′-terminus of the 5′ sequence, making it possible to detect the presence of a known mutation at a specific site by looking for the presence or absence of amplification.  
      The methods described herein may be performed, for example, by utilizing pre-packaged diagnostic kits comprising at least one probe nucleic acid or antibody reagent described herein, which may be conveniently used, e.g., in clinical settings to diagnose patients exhibiting symptoms or family history of a disease or illness involving a NOVX gene.  
      Furthermore, any cell type or tissue, preferably peripheral blood leukocytes, in which NOVX is expressed may be utilized in the prognostic assays described herein. However, any biological sample containing nucleated cells may be used, including, for example, buccal mucosal cells.  
      Pharmacogenonics  
      Agents, or modulators that have a stimulatory or inhibitory effect on NOVX activity (e.g., NOVX gene expression), as identified by a screening assay described herein can be administered to individuals to treat (prophylactically or therapeutically) disorders. The disorders include but are not limited to, e.g., those diseases, disorders and conditions listed above, and more particularly include those diseases, disorders, or conditions associated with homologs of a NOVX protein, such as those summarized in Table A.  
      In conjunction with such treatment, the pharmacogenomics (i.e., the study of the relationship between an individual&#39;s genotype and that individual&#39;s response to a foreign compound or drug) of the individual may be considered. Differences in metabolism of therapeutics can lead to severe toxicity or therapeutic failure by altering the relation between dose and blood concentration of the pharmacologically active drug. Thus, the pharmacogenomics of the individual permits the selection of effective agents (e.g., drugs) for prophylactic or therapeutic treatments based on a consideration of the individual&#39;s genotype. Such pharmacogenomics can further be used to determine appropriate dosages and therapeutic regimens. Accordingly, the activity of NOVX protein, expression of NOVX nucleic acid, or mutation content of NOVX genes in an individual can be determined to thereby select appropriate agent(s) for therapeutic or prophylactic treatment of the individual.  
      Pharmacogenomics deals with clinically significant hereditary variations in the response to drugs due to altered drug disposition and abnormal action in affected persons. See e.g., Eichelbaum, 1996.  Clin. Exp. Pharmacol. Physiol.,  23: 983-985; Linder, 1997.  Clin. Chem.,  43: 254-266. In general, two types of pharmacogenetic conditions can be differentiated. Genetic conditions transmitted as a single factor altering the way drugs act on the body (altered drug action) or genetic conditions transmitted as single factors altering the way the body acts on drugs (altered drug metabolism). These pharmacogenetic conditions can occur either as rare defects or as polymorphisms. For example, glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common inherited enzymopathy in which the main clinical complication is hemolysis after ingestion of oxidant drugs (anti-malarials, sulfonamides, analgesics, nitrofurans) and consumption of fava beans.  
      As an illustrative embodiment, the activity of drug metabolizing enzymes is a major determinant of both the intensity and duration of drug action. The discovery of genetic polymorphisms of drug metabolizing enzymes (e.g., N-acetyltransferase 2 (NAT 2) and cytochrome pregnancy zone protein precursor enzymes CYP2D6 and CYP2C19) has provided an explanation as to why some patients do not obtain the expected drug effects or show exaggerated drug response and serious toxicity after taking the standard and safe dose of a drug. These polymorphisms are expressed in two phenotypes in the population, the extensive metabolizer (EM) and poor metabolizer (PM). The prevalence of PM is different among different populations. For example, the gene coding for CYP2D6 is highly polymorphic and several mutations have been identified in PM, which all lead to the absence of functional CYP2D6. Poor metabolizers of CYP2D6 and CYP2C19 quite frequently experience exaggerated drug response and side effects when they receive standard doses. If a metabolite is the active therapeutic moiety, PM show no therapeutic response, as demonstrated for the analgesic effect of codeine mediated by its CYP2D6-formed metabolite morphine. At the other extreme are the so called ultra-rapid metabolizers who do not respond to standard doses. Recently, the molecular basis of ultra-rapid metabolism has been identified to be due to CYP2D6 gene amplification.  
      Thus, the activity of NOVX protein, expression of NOVX nucleic acid, or mutation content of NOVX genes in an individual can be determined to thereby select appropriate agent(s) for therapeutic or prophylactic treatment of the individual. In addition, pharmacogenetic studies can be used to apply genotyping of polymorphic alleles encoding drug-metabolizing enzymes to the identification of an individual&#39;s drug responsiveness phenotype. This knowledge, when applied to dosing or drug selection, can avoid adverse reactions or therapeutic failure and thus enhance therapeutic or prophylactic efficiency when treating a subject with a NOVX modulator, such as a modulator identified by one of the exemplary screening assays described herein.  
      Monitoring of Effects During Clinical Trials  
      Monitoring the influence of agents (e.g., drugs, compounds) on the expression or activity of NOVX (e.g., the ability to modulate aberrant cell proliferation and/or differentiation) can be applied not only in basic drug screening, but also in clinical trials. For example, the effectiveness of an agent determined by a screening assay as described herein to increase NOVX gene expression, protein levels, or upregulate NOVX activity, can be monitored in clinical trails of subjects exhibiting decreased NOVX gene expression, protein levels, or downregulated NOVX activity. Alternatively, the effectiveness of an agent determined by a screening assay to decrease NOVX gene expression, protein levels, or downregulate NOVX activity, can be monitored in clinical trails of subjects exhibiting increased NOVX gene expression, protein levels, or upregulated NOVX activity. In such clinical trials, the expression or activity of NOVX and, preferably, other genes that have been implicated in, for example, a cellular proliferation or immune disorder can be used as a “read out” or markers of the immune responsiveness of a particular cell.  
      By way of example, and not of limitation, genes, including NOVX, that are modulated in cells by treatment with an agent (e.g., compound, drug or small molecule) that modulates NOVX activity (e.g., identified in a screening assay as described herein) can be identified. Thus, to study the effect of agents on cellular proliferation disorders, for example, in a clinical trial, cells can be isolated and RNA prepared and analyzed for the levels of expression of NOVX and other genes implicated in the disorder. The levels of gene expression (i.e., a gene expression pattern) can be quantified by Northern blot analysis or RT-PCR, as described herein, or alternatively by measuring the amount of protein produced, by one of the methods as described herein, or by measuring the levels of activity of NOVX or other genes. In this manner, the gene expression pattern can serve as a marker, indicative of the physiological response of the cells to the agent. Accordingly, this response state may be determined before, and at various points during, treatment of the individual with the agent.  
      In one embodiment, the invention provides a method for monitoring the effectiveness of treatment of a subject with an agent (e.g., an agonist, antagonist, protein, peptide, peptidomimetic, nucleic acid, small molecule, or other drug candidate identified by the screening assays described herein) comprising the steps of (i) obtaining a pre-administration sample from a subject prior to administration of the agent; (ii) detecting the level of expression of a NOVX protein, mRNA, or genomic DNA in the preadministration sample; (iii) obtaining one or more post-admninistration samples from the subject; (iv) detecting the level of expression or activity of the NOVX protein, mRNA, or genomic DNA in the post-administration samples; (v) comparing the level of expression or activity of the NOVX protein, mRNA, or genomic DNA in the pre-administration sample with the NOVX protein, mRNA, or genomic DNA in the post administration sample or samples; and (vi) altering the administration of the agent to the subject accordingly. For example, increased administration of the agent may be desirable to increase the expression or activity of NOVX to higher levels than detected, i.e., to increase the effectiveness of the agent. Alternatively, decreased administration of the agent may be desirable to decrease expression or activity of NOVX to lower levels than detected, i.e., to decrease the effectiveness of the agent.  
      Methods of Treatment  
      The invention provides for both prophylactic and therapeutic methods of treating a subject at risk of (or susceptible to) a disorder or having a disorder associated with aberrant NOVX expression or activity. The disorders include but are not limited to, e.g., those diseases, disorders and conditions listed above, and more particularly include those diseases, disorders, or conditions associated with homologs of a NOVX protein, such as those summarized in Table A.  
      These methods of treatment will be discussed more fully, below.  
      Diseases and Disorders  
      Diseases and disorders that are characterized by increased (relative to a subject not suffering from the disease or disorder) levels or biological activity may be treated with Therapeutics that antagonize (i.e., reduce or inhibit) activity. Therapeutics that antagonize activity may be administered in a therapeutic or prophylactic manner. Therapeutics that may be utilized include, but are not limited to: (i) an aforementioned peptide, or analogs, derivatives, fragments or homologs thereof; (ii) antibodies to an aforementioned peptide; (iii) nucleic acids encoding an aforementioned peptide; (iv) administration of antisense nucleic acid and nucleic acids that are “dysfunctional” (i.e., due to a heterologous insertion within the coding sequences of coding sequences to an aforementioned peptide) that are utilized to “knockout” endogenous function of an aforementioned peptide by homologous recombination (see, e.g., Capecchi, 1989.  Science  244: 1288-1292); or (ν) modulators ( i.e., inhibitors, agonists and antagonists, including additional peptide mimetic of the invention or antibodies specific to a peptide of the invention) that alter the interaction between an aforementioned peptide and its binding partner.  
      Diseases and disorders that are characterized by decreased (relative to a subject not suffering from the disease or disorder) levels or biological activity may be treated with Therapeutics that increase (i.e., are agonists to) activity. Therapeutics that upregulate activity may be administered in a therapeutic or prophylactic manner. Therapeutics that may be utilized include, but are not limited to, an aforementioned peptide, or analogs, derivatives, fragments or homologs thereof; or an agonist that increases bioavailability.  
      Increased or decreased levels can be readily detected by quantifying peptide and/or RNA, by obtaining a patient tissue sample (e.g., from biopsy tissue) and assaying it in vitro for RNA or peptide levels, structure and/or activity of the expressed peptides (or mRNAs of an aforementioned peptide). Methods that are well-known within the art include, but are not limited to, immunoassays (e.g., by Western blot analysis, immunoprecipitation followed by sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis, immunocytochemistry, etc.) and/or hybridization assays to detect expression of mRNAs (e.g., Northern assays, dot blots, in situ hybridization, and the like).  
      Prophylactic Methods  
      In one aspect, the invention provides a method for preventing, in a subject, a disease or condition associated with an aberrant NOVX expression or activity, by administering to the subject an agent that modulates NOVX expression or at least one NOVX activity. Subjects at risk for a disease that is caused or contributed to by aberrant NOVX expression or activity can be identified by, for example, any or a combination of diagnostic or prognostic assays as described herein. Administration of a prophylactic agent can occur prior to the manifestation of symptoms characteristic of the NOVX aberrancy, such that a disease or disorder is prevented or, alternatively, delayed in its progression. Depending upon the type of NOVX aberrancy, for example, a NOVX agonist or NOVX antagonist agent can be used for treating the subject. The appropriate agent can be determined based on screening assays described herein. The prophylactic methods of the invention are further discussed in the following subsections.  
      Therapeutic Methods  
      Another aspect of the invention pertains to methods of modulating NOVX expression or activity for therapeutic purposes. The modulatory method of the invention involves contacting a cell with an agent that modulates one or more of the activities of NOVX protein activity associated with the cell. An agent that modulates NOVX protein activity can be an agent as described herein, such as a nucleic acid or a protein, a naturally-occurring cognate ligand of a NOVX protein, a peptide, a NOVX peptidomimetic, or other small molecule. In one embodiment, the agent stimulates one or more NOVX protein activity. Examples of such stimulatory agents include active NOVX protein and a nucleic acid molecule encoding NOVX that has been introduced into the cell. In another embodiment, the agent inhibits one or more NOVX protein activity. Examples of such inhibitory agents include antisense NOVX nucleic acid molecules and anti-NOVX antibodies. These modulatory methods can be performed in vitro (e.g., by culturing the cell with the agent) or, alternatively, in vivo (e.g., by administering the agent to a subject). As such, the invention provides methods of treating an individual afflicted with a disease or disorder characterized by aberrant expression or activity of a NOVX protein or nucleic acid molecule. In one embodiment, the method involves administering an agent (e.g., an agent identified by a screening assay described herein), or combination of agents that modulates (e.g., up-regulates or down-regulates) NOVX expression or activity. In another embodiment, the method involves administering a NOVX protein or nucleic acid molecule as therapy to compensate for reduced or aberrant NOVX expression or activity.  
      Stimulation of NOVX activity is desirable in situations in which NOVX is abnormally downregulated and/or in which increased NOVX activity is likely to have a beneficial effect. One example of such a situation is where a subject has a disorder characterized by aberrant cell proliferation and/or differentiation (e.g., cancer or immune associated disorders). Another example of such a situation is where the subject has a gestational disease (e.g., preclampsia).  
      Determination of the Biological Effect of the Therapeutic  
      In various embodiments of the invention, suitable in vitro or in vivo assays are performed to determine the effect of a specific Therapeutic and whether its administration is indicated for treatment of the affected tissue.  
      In various specific embodiments, in vitro assays may be performed with representative cells of the type(s) involved in the patient&#39;s disorder, to determine if a given Therapeutic exerts the desired effect upon the cell type(s). Compounds for use in therapy may be tested in suitable animal model systems including, but not limited to rats, mice, chicken, cows, monkeys, rabbits, and the like, prior to testing in human subjects. Similarly, for in vivo testing, any of the animal model system known in the art may be used prior to administration to human subjects.  
      Prophylactic and Therapeutic Uses of the Compositions of the Invention  
      The NOVX nucleic acids and proteins of the invention are useful in potential prophylactic and therapeutic applications implicated in a variety of disorders. The disorders include but are not limited to, e.g., those diseases, disorders and conditions listed above, and more particularly include those diseases, disorders, or conditions associated with homologs of a NOVX protein, such as those summarized in Table A.  
      As an example, a cDNA encoding the NOVX protein of the invention may be useful in gene therapy, and the protein may be useful when administered to a subject in need thereof. By way of non-limiting example, the compositions of the invention will have efficacy for treatment of patients suffering from diseases, disorders, conditions and the like, including but not limited to those listed herein.  
      Both the novel nucleic acid encoding the NOVX protein, and the NOVX protein of the invention, or fragments thereof, may also be useful in diagnostic applications, wherein the presence or amount of the nucleic acid or the protein are to be assessed. A further use could be as an anti-bacterial molecule (i.e., some peptides have been found to possess anti-bacterial properties). These materials are further useful in the generation of antibodies, which immunospecifically-bind to the novel substances of the invention for use in therapeutic or diagnostic methods.  
      The invention will be further described in the following examples, which do not limit the scope of the invention described in the claims.  
     EXAMPLES  
     Example A  
     Polynucleotide and Polypeptide Sequences, and Homology Data  
     Example 1  
      The NOV1clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 1A.  
               TABLE 1A                       NOV1 Sequence Analysis                                                NOV1a, CG191083-01   SEQ ID NO: 1   4494 bp           DNA Sequence   ORF Start: ATG at 59   ORF Stop: TAA at 1394                       CGAGAGCGGGAGTGAGCGAGCGAGCGAGTTGCCGAGCGCGCCCCGTCCCTCGCGCGCG   ATG CTCCCCT           GGACGGCGCTCGGCCTGGCCCTGAGCTTGCGGCTGGCGCTGGCGCGGAGCGGCGCAGAGCGCGGTCCA       CCAGCATCAGCCCCCCGAGGGGACCTGATGTTCCTGCTGGACAGCTCAGCCAGCGTCTCTCACTACGA       GTTCTCCCGGGTTCGGGAGTTTGTGGGGCAGCTGGTGGCTCCACTGCCCCTGGGCACCGGGGCCCTGC       GTGCCAGTCTGGTGCACGTGGGCAGTCGGCCATACACCGAGTTCCCCTTCGGCCAGCACAGCTCGGGT       GAGGCTGCCCAGGATGCGGTGCGTGCTTCTGCCCAGCGCATGGGTGACACCCACACTGGCCTGGCGCT       GGTCTATGCCAAGGAACAGCTGTTTGCTGAAGCATCAGGTGCCCGGCCAGGGGTGCCCAAAGTGCTGG       TGTGGGTGACAGATGGCGGCTCCAGCGACCCTGTGGGCCCCCCCATGCAGGAGCTCAAGGACCTGGGC       GTCACCGTGTTCATTGTCAGCACCGGCCGAGGCAACTTCCTGGAGCTGTCAGCCGCTGCCTCAGCCCC       TGCCGAGAAGCACCTGCACTTTGTGGACGTGGATGACCTGCACATCATTGTCCAAGAGCTGAGGGGCT       CCATTCTCGACGCGATGCGGCCGCAGCAGCTCCATGCCACGGAGATCACGTCCAGCGGCTTCCGCCTG       GCCTGGCCACCCCTGCTGACCGCAGACTCGGGCTACTATGTGCTGGAGCTGGTGCCCAGCGCCCAGCC       GGGGGCTGCAAGACGCCAGCAGCTGCCAGGGAACGCCACGGACTGGATCTGGGCCGGCCTCGACCCGG       ACACGGACTACGACGTGGCGCTAGTGCCTGAGTCCAACGTGCGCCTCCTGAGGCCCCAGATCCTGCGG       GTGCGCACGCGGCCCGGTGAGGCAGGGCCGGGGGCTTCGGGCCCGGAGTCGGGGGCTGGGCCGGCCCC       CACGCAGCTCGCCGCCCTCCCCGCCCCAGAGGAGGCCGGGCCAGAGCGCATCGTCATCTCCCACGCCC       GGCCGCGCAGCCTCCGCGTGAGTTGGGCCCCAGCGCTGGGCTCAGCCGCGGCGCTCGGCTACCACGTG       CAGTTCGGGCCGCTGCGGGGCGGGGAGGCGCAGCGGGTGGAGGTGCCCGCGGGCCGCAACTGCACCAC       GCTGCAGGGCCTGGCGCCGGGCACCGCCTACCTGGTGACCGTGACCGCCGCCTTCCGCTCGGGCCGCG       AGAGCGCGCTGTCCGCCAAGGCCTGCACGCCCGACGGCCCGCGCCCGCGCCCACGCCCCGTGCCCCGC       GCCCCGACCCCGGGGACCGCCAGCCGTGAGCCG TAA   GCCGGCGTCCCCGCCCAGCCGAGAGGGCCGGC           GCCTACCTGAGGGCCCCTGTGTCCCGAACCCGGAGCGGAGGCGCCCAACCCGGCAGACGGGTGCAGGC           CCGGCCTTTCCCCACGCGGACTCCGCGCGACCCCGGCCCTCTCCCTGCGGCCGCAGGGCTTCCCCGCC           TGGCGCCTGCCCTCCAGGGCTGGGGCCTCGCCTGGCGGGACCCCGCAGCAGCCCCGGCCCCATCCCCC           CCCAGAGCCGGGCGTCGTGTGGGTCCGTGGGTGATAATTGAGAGCGTCAGACCCAGGACTGTTCAGGC           CAGCTTGGGTCCTGGACGTTGATAGGAAGCGGAAGGGGAATCGCGGGAAGCTGGCCCAGGTCAGGTCC           GCAAAGGCTTCTGAAGAAGAGGAAGGGCGAGTAGGGGCACCTGGACGCTGATGGTGGCCAGGATGCTC           AGCTGGCCAGGAGGGCAGCACCTGCTGGGGACGGTGGCCCTGCCTTCATGCCCAGGACACCAGCTGGG           TCCAGCTAGCAGCCACTGGGAATCAGAGGAATGGGGCAGAGCTGGCCATTCAGGACCTTGAGGACAGG           TGACCCCACCCGCCCACCGCCACTATCAGGCCCCGGGACCGCACTCACAGGAAACCTTCCGTCGTGAC           GGAGCACTTCCCAGGGGCCGCAGGGACGACACTCTCCAGGGAGGCCCCAGCAACCACACCATCTTCTT           GCTGTGAGAGGTCTCACCCCGGGCTACCTCCTGTCACTACTCACTGCCCTGGGGTCCGTGGGCAAGTT           GCCCAGGGTGGGGGTGCCTAGCCAGGTGCAGTCCCCGCCCCGCCTAGTCCTCGGCGTCACGCAATGCT           CACCTCGCCTCTTCCCCACTAACATCCCAGACTTTAAAATTCAGTAAATCAGATGTACACCGAGCCTC           CAGTCTCGCTAGGATGCTTTACTCCTCCACAAACAGCAGCCGCCGACAGGACAGCTTGTGAACGTCTC           CGCCTTTTGGGGTGTCCGGGGAGAGGAGGTGGAGCTGTCCCCTCCCAGTGTCAGGCCTCCTTGGTCCT           CATGTGCACCTTTTATTCAGAGAGCTTGGGCCCCCTTCCTTTGGAGCTGGGCCCAGGGCAGGTGGCTG           GAATGCAGAGGACAAGGGGGCTGGGGCCTCTGCAGGGCCATTCCCACCGCAGTCTCTGCCACGGCCCG           GAGCCCTGGGCCCAGGGCCACGCGGGCTCCCTCTGCTGGCAAAGCCACACCCTGCACCGCATGGGGTC           CACTGCCCCTTTCCCCACGTGGACTCTGCGTGACCCCAGGAACTGCAGCATTGAGGTGGTCTCAGTCC           CTCCCTCAGGTCTGGTGGGCATTGTGCCAGGGGCCACCTTCGGGACAGCTGGCCTTGGCACCGTCTCC           CAAGAACCCAGCTCTGTGCATCCCGTGGCCCCACCAGAAACCCAAGGCCACACCGCCCACCAGCTGGG           TGTGGTCACCATTCATGGAGGGCCGGCTGGGGCCAGGCTCACCACGCAGAGTTTGCCCTCCGGTGTGA           TGATGCATGAGACACAGTAGGCCCCCCTGCCTGTGTGTGCAGGGGGTGTCTGTGGGGGGGCCCTGCTG           GCTGGACTTTCGGTTTCTCCTGAGCTCCCCTTAGCCCCCAAGTCAGGCCACGGAGGCCTGAGTAGGAC           CCATGGGCTGTGTGTGTCACTGCAGGTGGCGTGCTCACAACTGCACTGCTGGTCGGCAGGTGGCCAGG           GTTGCAGGCCCGGGCCTCGGGCCCCACCTCCTCTGGAGGGGTAGGATCTCCTTCGTGCAGCCCCTGCC           CCCTACCCTGTTCTCCGGAGTGTTGGCAGATCTGAGCCCACGGTCACGTGAGAGGAGATGCCTCTTGC           ACACTGAGCCCAGGCCCAGCTCACGGAGCACCCTGCAGGTGGCAGCGGGGCACCAGGGGCTCATTCCT           GGTGGCCTCAGTGGCTTCTGTGGACGACTCAGACTCACATGAGAAGCTGGGAGGAGCTCCAGCTCTGC           AATCCCGAGAGGGCAGAGCGGGGGCCCTGGCCACAACCCTGCTCCCCACATACCCGTCTGGCAGAGGC           TCTGCCTCCCCTCTGCCCATCTCTGCACACCAAGGCTGAGCACAGCACAAGGCCTCACGGAGAGGGTG           AAAAGGCACTGCCGTCTCCATCTCAGTGCCAAGGAATGCCCCTTTCAGAAGCCCTCGTCTGAGAAGTG           CTGCCCCTTATGTAGCCCCAGGCATTTTAAAATCTTTGAATCTGCACCAAGTCTCAGAACAGCTCTGG           CCCCGGAGTGCTCCGTCCAGGCCGCTGTGAACCGGCTGTCCCCGCGTCTCCTCCACCTCCCCTGACAC           AATCCTGGCCCCGACTCAGTCCACCCAGGGTGCAGTGCAGAGGCTGATACCCGCCAGGACTTCCTTGC           CAAGGGCCCGGCCACGTCACAAGGCCACTGCACGCTTTTCGACATGCACCTGGAAATCGGGAAGGGCC           ATGCTGCAGTTGCTTCTAGTTGAGACGAGAAGAGCGACAAGGTTGTGATCCACGTGGCAGGTGTTCAG           AAGGCTGGGGGCGGGCAGCGCTGGGGAGAGCCCTGGGTACTTCGAGGAGACCCCGAAGGGAGGCTGCT           CCCACACCTGCGCCAGTTTCCACCCTCTCTGTGAGCAGGGCTGCGGTCACCTCCCACATCTGAAGAGA           ACCAACCTGAGGATTTCACGCTGGCTGCGTGCCAGACCAGTCCCTGACAGGTTGTGCGAGGCCCTTCG           CTGGACAGCCCATTGCTGGCCACTGGACGGAGAGGCAGAGGGGGCTGAAATTCGGGCCCATGCCTCTG           TGAGCGATGACGGAGCAACAGCTCTCCAGCACGTGAAGCTCTCCAGACAGCTGTTCGTGAGAAGCCAG           ACAGAGGCCTGGGGTCTCAGTCCAGATTTCTGGGGAGTGGGGTGTCCAAGCGTGGGCCACGCTGCTGG           GAGCCACCTAGGGAAGCAGGTCGCCTGTTTCTATAGTGACGGTAATAAACCAAGTCAATTTTCTATAA           AAAAAA                                           NOV1a, CG191083-01   SEQ ID NO: 2   445 aa   MW at 46803.5kD           Protein Sequence                     MLPWTALGLALSLRLALARSGAERGPPASAPRGDLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGT           GALRASLVHVGSRPYTEFPFGQHSSGEAAQDAVRASAQRMGDTHTGLALVYAKEQLFAEASGARPGVP       KVLVWVTDGGSSDPVGPPMQELKDLGVTVFIVSTGRGNFLELSAAASAPAEKHLHFVDVDDLHIIVQE       LRGSILDAMRPQQLHATEITSSGFRLAWPPLLTADSGYYVLELVPSAQPGAARRQQLPGNATDWIWAG       LDPDTDYDVALVPESNVRLLRPQILRVRTRPGEAGPGASGPESGAGPAPTQLAALPAPEEAGPERIVI       HARPRSLRVSWAPALGSAAALGYHVQFGPLRGGEAQRVEVPAGPNCTTLQGLAPGTAYLVTVTAAFR       SGRESALSAKACTPDGPRPRPRPVPRAPTPGTASREP                  
 
      Further analysis of the NOV1a protein yielded the following properties shown in Table 1B.  
               TABLE 1B                       Protein Sequence Properties NOV1a                                        SignalP analysis:   Cleavage site between residues 19 and 20       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 0; pos. chg 0; neg. chg 0           H-region:   length 13; peak value 8.36           PSG score:   3.96                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 2.40           possible cleavage site: between 18 and 19                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 18)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 19           Tentative number of TMS(s) for the threshold 0.5: 0           number of TMS(s) . . . fixed                             PERIPHERAL   Likelihood = 2.17 (at 60)                         ALOM score: 2.17 (number of TMSs: 0)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 9           Charge difference: 1.0 C(2.0)-N(1.0)           C &gt; N: C-terminal side will be inside                 &gt;&gt;&gt;Caution: Inconsistent mtop result with signal peptide                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   2   Hyd Moment(75):   2.90           Hyd Moment(95):   1.31   G content:   2           D/E content:   1   S/T content:   3                         Score: −4.22       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 29 ARS|GA                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 9.2%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 76.7       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         33.3%: extracellular, including cell wall           33.3%: mitochondrial           22.2%: vacuolar           11.1%: endoplasmic reticulum                 &gt;&gt; prediction for CG191083-01 is exc (k = 9)                  
 
      A search of the NOV1a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 1C.  
               TABLE 1C                          Geneseq Results for NOV1a                                             Identities/                   NOV1a   Similarities       Geneseq   Protein/Organism/Length   Residues/   for the   Expect       Identifier   [Patent #, Date]   Match Residues   Matched Region   Value               ABP69674   Human polypeptide SEQ ID NO 1721 -   1 . . . 445   445/445 (100%)   0.0             Homo sapiens , 445 aa.   1 . . . 445   445/445 (100%)           [WO200270539-A2, 12-SEP-2002]       AAE32502   Human Willebrand Factor A domain   1 . . . 445   418/445 (93%)   0.0           related-protein (WARP) -  Homo     1 . . . 418   418/445 (93%)             sapiens , 418 aa. [WO200288184-A1,           07-NOV-2002]       AAE32501   Mouse Willebrand Factor A domain   1 . . . 445   324/445 (72%)   0.0           related-protein (WARP) -  Mus  sp, 415   1 . . . 415   356/445 (79%)           aa. [WO200288184-A1, 07-NOV-2002]       AAW86326   Kidney injury associated molecule   1 . . . 445   325/445 (73%)   e−179           HW059 protein -  Rattus  sp, 421 aa.   7 . . . 421   356/445 (79%)           [WO9853071-A1, 26-NOV-1998]       AAB42581   Human ORFX ORF2345 polypeptide   3 . . . 296   274/294 (93%)   e−150           sequence SEQ ID NO: 4690 -  Homo     10 . . . 299    274/294 (93%)             sapiens , 299 aa. [WO200058473-A2,           05-OCT-2000]                  
 
      In a BLAST search of public sequence databases, the NOV1a protein was found to have homology to the proteins shown in the BLASTP data in Table 1D.  
               TABLE 1D                          Public BLASTP Results for NOV1a                                             Identities/           Protein       NOV1a   Similarities       Accession       Residues/   for the   Expect       Number   Protein/Organism/Length   Match Residues   Matched Portion   Value               Q8R2Z5   Hypothetical protein (VON   1 . . . 445   325/445 (73%)   e−180           WILLEBRAND factor A-related   1 . . . 415   356/445 (79%)           protein homolog) -  Mus musculus             (Mouse), 415 aa.       Q8C0Q7   VON WILLEBRAND factor A-related   1 . . . 445   324/445 (72%)   e−180           protein homolog -  Mus musculus     1 . . . 415   355/445 (78%)           (Mouse), 415 aa.       Q923K3   Von Willebrand factor A-related   1 . . . 445   324/445 (72%)   e−180           protein -  Mus musculus  (Mouse),   1 . . . 415   356/445 (79%)           415 aa.       CAC39705   Sequence 47 from Patent EP1067182 -   1 . . . 257   253/257 (98%)   e−142             Homo sapiens  (Human), 285 aa.   1 . . . 257   254/257 (98%)       Q9H6J5   Hypothetical protein FLJ22215 -   213 . . . 445    233/233 (100%)   e−134             Homo sapiens  (Human), 233 aa.   1 . . . 233   233/233 (100%)                  
 
      PFam analysis predicts that the NOV1a protein contains the domains shown in the Table 1E.  
               TABLE 1E                          Domain Analysis of NOV1a                                     Identities/                   Similarities       Pfam       for the       Domain   NOV1a Match Region   Matched Region   Expect Value                                         vwa   34 . . . 205   68/194   (35%)   1.5e−40               132/194   (68%)       fn3   212 . . . 287   22/85   (26%)   0.18               52/85   (61%)       fn3   332 . . . 413   30/85   (35%)   1.4e−11               53/85   (62%)                  
 
     Example 2  
      The NOV2 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 2A.  
               TABLE 2A                       NOV2 Sequence Analysis                                                Nov2a, CG191745-01   SEQ ID NO: 3   3462 bp           DNA Sequence   ORF Start: ATG at 2   ORF Stop: TGA at 3443                       G   ATG GGGCCAGAACGGACAGGGGCCGCGCCGCTGCCGCTGCTGCTGGTGTTAGCGCTCAGTCAAGGCA           TTTTAAATTGTTGTTTGGCCTACAATGTTGGTCTCCCAGAAGCAAAAATATTTTCCGGTCCTTCAAGT       GAACAGTTTGGCTATGCAGTGCAGCAGTTTATAAATCCAAAAGGCAACTGGTTACTGGTTGGTTCACC       CTGGAGTGGCTTTCCTGAGAACCGAATGGGAGATGTGTATAAATGTCCTGTTGACCTATCCACTGCCA       CATGTGAAAAACTAAATTTGCAAACTTCAACAAGCATTCCAAATGTTACTGAGATGAAAACCAACATG       AGCCTCGGCTTGATCCTCACCAGGAACATGGGAACTGGAGGTTTTCTCACATGTGGTCCTCTGTGGGC       ACAGCAATGTGGGAATCAGTATTACACAACGGGTGTGTGTTCTGACATCAGTCCTGATTTTCAGCTCT       CAGCCAGCTTCTCACCTGCAACTCAGCCCTGCCCTTCCCTCATAGATGTTGTGGTTGTGTGTGATGAA       TCAAATAGTATTTATCCTTGGGATGCAGTAAAGAATTTTTTGGAAAAATTTGTACAAGGCCTGGATAT       AGGCCCCACAAAGACACAGGTGGGGTTAATTCAGTATGCCAATAATCCAAGAGTTGTGTTTAACTTGA       ACACATATAAAACCAAAGAAGAAATGATTGTAGCAACATCCCAGACATCCCAATATGGTGGGGACCTC       ACAAACACATTCGGAGCAATTCAATATGCAAGAAAATATGCTTATTCAGCAGCTTCTGGTGGGCGACG       AAGTGCTACGAAAGTAATGGTAGTTGTAACTGACGGTGAATCACATGATGGTTCAATGTTGAAAGCTG       TGATTGATCAATGCAACCATGACAATATACTGAGGTTTGGCATAGCAGTTCTTGGGTACTTAAACAGA       AACGCCCTTGATACTAAAAATTTAATAAAAGAAATAAAAGCAATCGCTAGTATTCCAACAGAAAGATA       CTTTTTCAATGTGTCTGATGAAGCAGCTCTACTAGAAAAGGCTGGGACATTAGGAGAACAAATTTTCA       GCATTGAAGGTACTGTTCAAGGAGGAGACAACTTTCAGATGGAAATGTCACAAGTGGGATTCAGTGCA       GATTACTCTTCTCAAAATGATATTCTGATGCTGGGTGCAGTGGGAGCTTTTGGCTGGAGTGGGACCAT       TGTCCAGAAGACATCTCATGGCCATTTGATCTTTCCTAAACAAGCCTTTGACCAAATTCTGCAGGACA       GAAATCACAGTTCATATTTAGGTTACTCTGTGGCTGCAATTTCTACTGGAGAAAGCACTCACTTTGTT       GCTGGTGCTCCTCGGGCAAATTATACCGGCCAGATAGTGCTATATAGTGTGAATGAGAATGGCAATAT       CACGGTTATTCAGGCTCACCGAGGTGACCAGATTGGCTCCTATTTTGGTAGTGTGCTGTGTTCAGTTG       ATGTGGATAAAGACACCATTACAGACGTGCTCTTGGTAGGTGCACCAATGTACATGAGTGACCTAAAG       AAAGAGGAAGGAAGAGTCTACCTGTTTACTATCAAAGAGGGCATTTTGGGTCAGCACCAATTTCTTGA       AGGCCCCGAGGGCATTGAAAACACTCGATTTGGTTCAGCAATTGCAGCTCTTTCAGACATCAACATGG       ATGGCTTTAATGATGTGATTGTTGGTTCACCACTAGAAAATCAGAATTCTGGAGCTGTATACATTTAC       AATGGTCATCAGGGCACTATCCGCACAAAGTATTCCCAGAAAATCTTGGGATCCGATGGAGCCTTTAG       GAGCCATCTCCAGTACTTTGGGAGGTCCTTGGATGGCTATGGAGATTTAAATGGGGATTCCATCACCG       ATGTGTCTATTGGTGCCTTTGGACAAGTGGTTCAACTCTGGTCACAAAGTATTGCTGATGTAGCTATA       GAAGCTTCATTCACACCAGAAAAAATCACTTTGGTCAACAAGAATGCTCAGATAATTCTCAAACTCTG       CTTCAGTGCAAAGTTCAGACCTACTAAGCAAAACAATCAAGTGGCCATTGTATATAACATCACACTTG       ATGCAGATGGATTTTCATCCAGAGTAACCTCCAGGGGGTTATTTAAAGAAAACAATGAAAGGTGCCTG       CAGAAGAATATGGTAGTAAATCAAGCACAGAGTTGCCCCGAGCACATCATTTATATACAGGAGCCCTC       TGATGTTGTCAACTCTTTGGATTTGCGTGTGGACATCAGTCTGGAAAACCCTGGCACTAGCCCTGCCC       TTGAAGCCTATTCTGAGACTGCCAAGGTCTTCAGTATTCCTTTCCACAAAGACTGTGGTGAGGACGGA       CAGCAACCAAAACAAAAGGTTAACATTTTCAGTAACGCTGAAAAATAAAAGGGAAAGTGCATACAACA       GAAGTAACATGCCAGGTGGCTGCATCTCAGAAGTCTGTTGCCTGCGATGTAGGCTACCCTGCTTTAAA       GAGAGAACAACAGGTGACTTTTACTATTAACTTTGACTTCAATCTTCAAAACCTTCAGAATCAGGCGT       ATTCCTCTCCTGTATGATGCTGAAATTCACTTAACAAAGGTAACAACAGGAAGTGTTCCAGTAAGCAT       TGCAAACAGACAAGGCTGGTGACATCAGTTGTAATGCAGATATCAATCCACTGAAAATAGGACAAACA       TCTTCTTCTGTATCTTTCAAAAGTGAAAATTTCAGGCACACCAAAGAATTGAACTGCAGAACTGCTTC       CTGTAGTAATGTTACCTGCTGGTTGAAAGACGTTCACATGAAAGGAGAATACTTTGTTAATGTGACTA       CCAGAATTTGGAACGGGACTTTCGCATCATCAACGTTCCAGACAGTACAGCTAACGGCAGCTGCAGAA       ATCAACACCTATAACCCTGAGATATATGTGATTGAAGATAACACTGTTACGATTCCCCTGATGATAAT       GAAACCTGATGAGAAAGCCGAAGTACCAACAGGAGTTATAATAGGAAGTATAATTGCTGGAATCCTTT       TGCTGTTAGCTCTGGTTGCAATTTTATGGAAGCTCGGCTTCTTCAAAAGAAAATATGAAAAGATGACC       AAAAATCCAGATGAGATTGATGAGACCACAGAGCTCAGTAGC TGA   ACCAGCAGACCTACCTG                                           NOV2a, CG191745-01   SEQ ID NO: 4   1147 aa   MW at 125495.9kD           Protein Sequence                     MGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKGNWLLVGSP           WSGFPENRMGDVYKCPVDLSTATCEKLNLQTSTSIPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWA       QQCGNQYYTTGVCSDISPDFQLSASFSPATQPCPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDI       GPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGRR       SATKVMVVVIDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERY       FFNVSDEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYSSQNDILMLGAVGAFGWSGTI       VQKTSHGHLIFPKQAFDQILQDRNHSSYLGYSVAAISTGESTHFVAGAPRANYTGQIVLYSVNENGNI       TVIQAHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMSDLKKEEGRVYLFTIKEGILGQHQFLE       GPEGIENTRFGSAIAALSDINMDGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKYSQKILGSDGAFR       SHLQYFGRSLDGYGDLNGDSITDVSIGAFGQVVQLWSQSIADVAIEASFTPEKITLVNKNAQIILKLC       FSAKFRPTKQNNQVAIVYNITLDADGFSSRVTSRGLFKENNERCLQKNMVVNQAQSCPEHIIYIQEPS       DVVNSLDLRVDISLENPGTSPALEAYSETAKVFSIPFHKDCGEDGLCISDLVLDVRQIPAAQEQPFIV       SNQNKRLTFSVTLKNKRESAYNTGIVVDFSENLFFASFSLPVDGTEVTCQVAASQKSVACDVGYPALK       REQQVTFTINFDFNLQNLQNQASLSFQALSESQEENKADNLVNLKIPLLYDAEIHLTKVTTGSVPVSM       ATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQTSSSVSEKSENFRHTKELNCRTAS       CSNVTCWLKDVHMKGEYFVNVTTRIWNGTFASSTFQTVQLTAAAEINTYNPEIYVIEDNTVTIPLMIM       KPDEKAEVPTGVIIGSIIAGILLLLALVAILWKLGFFKRKYEKMTKNPDEIDETTELSS                  
 
      Further analysis of the NOV2a protein yielded the following properties shown in Table 2B.  
               TABLE 2B                       Protein Sequence Properties NOV2a                                        SignalP analysis:   Cleavage site between residues 30 and 31       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 5; pos. chg 1; neg. chg 1           H-region:   length 30; peak value 9.82           PSG score:   5.42                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 1.12           possible cleavage site: between 22 and 23                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 22)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 23           Tentative number of TMS(s) for the threshold 0.5: 2           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 1100-1116               −13.27                             PERIPHERAL   Likelihood = 0.95 (at 943)                         ALOM score: −13.27 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 11           Charge difference: −2.0 C(−1.0)-N(1.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 1a (cytoplasmic tail 1117 to 1147)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:    1   Hyd Moment(75):   10.10           Hyd Moment(95):    5.95   G content:   4           D/E content:    2   S/T content:   2                         Score: −6.90       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 15 ERT|GA                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 7.7%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: GPER                 none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: 1128       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         55.6%: endoplasmic reticulum           22.2%: Golgi           11.1%: plasma membrane           11.1%: extracellular, including cell wall                 &gt;&gt; prediction for CG191745-01 is end (k = 9)                  
 
      A search of the NOV2a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 2C.  
               TABLE 2C                          Geneseq Results for NOV2a                                         NOV2a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               AAG79775   Alpha2 integrin -  Homo sapiens , 1181   1 . . . 1147   1146/1181 (97%)   0.0           aa. [WO2002101070-A2, 19-DEC-   1 . . . 1181   1147/1181 (97%)           2002]       ABU03548   Angiogenesis-associated human   1 . . . 1147   1146/1181 (97%)   0.0           protein sequence #93 -  Homo     1 . . . 1181   1147/1181 (97%)             sapiens , 1181 aa. [WO200279492-A2,           10-OCT-2002]       ABU03617   Human expressed protein tag (EPT)   1 . . . 1147   1146/1181 (97%)   0.0           #283 -  Homo sapiens , 1181 aa.   1 . . . 1181   1147/1181 (97%)           [WO200278524-A2, 10-OCT-2002]       ABU03616   Human expressed protein tag (EPT)   1 . . . 1147   1146/1181 (97%)   0.0           #282 -  Homo sapiens , 1181 aa.   1 . . . 1181   1147/1181 (97%)           [WO200278524-A2, 10-OCT-2002]       ABU03614   Human expressed protein tag (EPT)   1 . . . 1147   1146/1181 (97%)   0.0           #280 -  Homo sapiens , 1181 aa.   1 . . . 1181   1147/1181 (97%)           [WO200278524-A2, 10-OCT-2002]                  
 
      In a BLAST search of public sequence databases, the NOV2a protein was found to have homology to the proteins shown in the BLASTP data in Table 2D.  
               TABLE 2D                          Public BLASTP Results for NOV2a                                         NOV2a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             P17301   Integrin alpha-2 precursor (Platelet   1 . . . 1147   1146/1181   (97%)   0.0           membrane glycoprotein la) (GPla)   1 . . . 1181   1147/1181   (97%)           (Collagen receptor) (VLA-2 alpha           chain) (CD49b) -  Homo sapiens             (Human), 1181 aa.       P53710   Integrin alpha-2 precursor (Platelet   12 . . . 1147    986/1170   (84%)   0.0           membrane glycoprotein la) (GPla)   1 . . . 1170   1069/1170   (91%)           (Collagen receptor) (VLA-2 alpha           chain) (CD49b) -  Bos taurus  (Bovine),           1170 aa (fragment).       Q62469   Integrin alpha-2 precursor (Platelet   1 . . . 1147   945/1181   (80%)   0.0           membrane glycoprotein la) (GPla)   1 . . . 1178   1040/1181   (88%)           (Collagen receptor) (VLA-2 alpha           chain) (CD49b) -  Mus musculus             (Mouse), 1178 aa.       P18614   Integrin alpha-1 precursor (Laminin   1 . . . 1131   471/1202   (39%)   0.0           and collagen receptor) (VLA-1)   1 . . . 1176   678/1202   (56%)           (CD49a) -  Rattus norvegicus  (Rat),           1180 aa.       O42094   ALPHA1 integrin -  Gallus gallus     29 . . . 1131    456/1179   (38%)   0.0           (Chicken), 1171 aa.   17 . . . 1167    671/1179   (56%)                  
 
      PFam analysis predicts that the NOV2a protein contains the domains shown in the Table 2E.  
               TABLE 2E                          Domain Analysis of NOV2a                                     Identities/           Pfam   NOV2a   Similarities for   Expect       Domain   Match Region   the Matched Region   Value                                         vwa   174 . . . 361   64/203   (32%)   1.1e−47               146/203   (72%)       FG-GAP   491 . . . 554   18/64   (28%)   0.00012               52/64   (81%)       FG-GAP   555 . . . 602   14/52   (27%)   0.00062               37/52   (71%)       FG-GAP   618 . . . 661   14/51   (27%)   0.073               32/51   (63%)       integrin_A   1121 . . . 1135   8/15   (53%)   0.0048               14/15   (93%)                  
 
     Example 3  
      The NOV3 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 3A.  
               TABLE 3A                       NOV3 Sequence Analysis                                                NOV3a, CG50253-01   SEQ ID NO: 5   1882 bp           DNA Sequence   ORF Start: ATG at 243   ORF Stop: TAA at 1851                       GGACACTGACATGGACTGAAGGAGTAGAAAAGAAGGGAGCGGGAGGGGGCTCCGGGCGCCGCGCAGCA               GACCTACTCCGGCCGCGCGCCTCGCCGCTGTCCTCCGGGAGCGGCAGCAGTAGCCCGGGCGGCGAGGG           CTGGGGGTTCCTCGAGACTCTCAGAGGGGCGCCTCCCATCGGCGCCCACCACCCCAACCTGTTCCTCG           CGCGCCACTGCGCTGCGCCCCAGGACCCGCTGCCCAAC   ATG GATTTTCTCCTGGCGCTGGTGCTGGTA       TCCTCGCTCTACCTGCAGGCGGCCGCCGAGTTCGACGGGAGGTGGCCCAGGCAAATAGTGTCATCGAT       TGGCCTATGTCGTTATGGTGGGAGGATTGACTGCTGCTGGGGCTGGGCTCGCCAGTCTTGGGGACAGT       GTCAGCCTGTGTGCCAACCACGATGCAAACATGGTGAATGTATCGGGCCAAACAAGTGCAAGTGTCAT       CCTGGTTATGCTGGAAAAACCTGTAATCAAGATCTAAATGAGTGTGGCCTGAAGCCCCGGCCCTGTAA       GCACAGGTGCATGAACACTTACGGCAGCTACAAGTGCTACTGTCTCAACGGATATATGCTCATGCCGG       ATGGTTCCTGCTCAAGTGCCCTGACCTGCTCCATGGCAAACTGTCAGTATGGCTGTGATGTTGTTAAA       GGACAAATACGGTGCCAGTGCCCATCCCCTGGCCTGCAGCTGGCTCCTGATGGGAGGACCTGTGTAGA       TGTTGATGAATGTGCTACAGGAAGAGCCTCCTGCCCTAGATTTAGGCAATGTGTCAACACTTTTGGGA       GCTACATCTGCAAGTGTCATAAAGGCTTCGATCTCATGTATATTGGAGGCAAATATCAATGTCATGAC       ATAGACGAATGCTCACTTGGTCAGTATCAGTGCAGCAGCTTTGCTCGATGTTATAACATACGTGGGTC       CTACAAGTGCAAATGTAAAGAAGGATACCAGGGTGATGGACTGACTTGTGTGTATATCCCAAAAGTTA       TGATTGAACCTTCAGGTCCAATTCATGTACCAAAGGGAAATGGTACCATTTTAAAGGGTGACACAGGA       AATAATAATTGGATTCCTGATGTTGGAAGTACTTGGTGGCCTCCGAAGACACCATATATTCCTCCTAT       CATTACCAACAGGCCTACTTCTAAGCCAACAACAAGACCTACACCAAAGCCAACACCAATTCCTACTC       CACCACCACCACCACCCCTGCCAACAGAGCTCAGAACACCTCTACCACCTACAACCCCAGAAAGGCCA       ACCACCGGACTGACAACTATAGCACCAGCTGCCAGTACACCTCCAGGAGGGATTACAGTTGACAACAG       GGTACAGACAGACCCTCAGAAACCCAGAGGAGATGTGTTCAGTGTTCTGGTACACAGTTGTAATTTTG       ACCATGGACTTTGTGGATGGATCAGGGAGAAAGACAATGACTTGCACTGGGAACCAATCAGGGACCCA       GCAGGTGGACAATATCTGACAGTGTCGGCAGCCAAAGCCCCAGGGGGAAAAGCTGCACGCTTGGTGCT       ACCTCTCGGCCGCCTCATGCATTCAGGGGACCTGTGCCTGTCATTCAGGCACAAGGTGACGGGGCTGC       ACTCTGGCACACTCCAGGTGTTTGTGAGAAAACACGGTGCCCACGGAGCAGCCCTGTGGGGAAGAAAT       GGTGGCCATGGCTGGAGGCAAACACAGATCACCTTGCGAGGGGCTGACATCAAGAGCGTCGTCTTCAA       AGGTGAAAAAAGGCGTGGTCACACTGGGGAGATTGGATTAGATGATGTGAGCTTGAAAAAAGGCCACT       GCTCTGAAGAACGCT AA   CAACTCCAGAACTAACAATGAACTCCTAA                                                   NOV3a, CG50253-01   SEQ ID NO: 6   536 aa   MW at 58650.8kD               Protein Sequence                     MDFLLALVLVSSLYLQAAAEFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVCQPRCKHGE           CIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMA       NCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLM       YIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKG       NGTILKGDTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELRT       PLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFSVLVHSCNFDHGLCGWIREKDN       DLHWEPIRDPAGGQYLTVSAAKAPGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHG       AHGAALWGRNGGHGWRQTQITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEER                                     NOV3b, 250095765   SEQ ID NO: 7   1765 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCATGGATTTTCTCCTGGCGCTGGTGCTGGTATCCTCGCTCTACCTGCAGGCGGCCGCCG           AGTTCGACGGGAGGTGGCCCAGGCAAATAGTGTCATCGATTGGCCTATGTCGTTATGGTGGGAGGATT       AATAGCCAGGATAAGGTGCCAGCTCAAAGCTGTGTGCCAACCACGATGCAAACATGGTGAATGTATCG       GGCCAAACAAGTGCAAGTGTCATCCTGGTTATGCTGGAAAAACCTGTAATCAAGATCTAAATGAGTGT       GGCCTGAAGCCCCGGCCCTGTAAGCACAGGTGCATGAACACTTACGGCAGCTACAAGTGCTACTGTCT       CAACGGATATATGCTCATGCCGGATGGTTCCTGCTCAAGTGCCCTGACCTGCTCCATGGCAAACTGTC       AGTATGGCTGTGATGTTGTTAAAGGACAAATACGGTGCCAGTGCCCATCCCCTGGCCTGCAGCTGGCT       CCTGATGGGAGGACCTGTGTAGATGTTGATGAATGTGCTACAGGAAGAGCCTCCTGCCCTAGATTTAG       GCAATGTGTCAACACTTTTGGGAGCTACATCTGCAAGTGTCATAAAGGCTTCGATCTCATGTATATTG       GAGGCAAATATCAATGTCATGACATAGACGAATGCTCACTTGGTCAGTATCAGTGCAGCAGCTTTGCT       CGATGTTATAACGTACGTGGGTCCTACAAGTGCAAATGTAAAGAAGGATACCAGGGTGATGGACTGAC       TTGTGTGTATATCCCAAAAGTTATGATTGAACCTTCAGGTCCAATTCATGTACCAAAGGGAAATGGTA       CCATTTTAAAGGGTGACACAGGAAATAATAATTGGATTCCTGATGTTGGAAGTACTTGGTGGCCTCCG       AAGACACCATATATTCCTCCTATCATTACCAACAGGCCTACTTCTAAGCCAACAACAAGACCTACACC       AAAGCCAACACCAATTCCTACTCCACCACCACCACCACCCCTGCCAACAGAGCTCAGAACACCTCTAC       CACCTACAACCCCAGAAAGGCCAACCACCGGACTGACAACTATAGCACCAGCTGCCAGTACACCTCCA       GGAGGGATTACAGTTGACAACAGGGTACAGACAGACCCTCAGAAACCCAGAGGAGATGTGTTCATTCC       ACGGCAACCTTCAAATGACTTGTTTGAAATATTTGAAATAGAAAGAGGAGTCAGTGCAGACGATGAAG       CAAAGGATGATCCAGGTGTTCTGGTACACAGTTGTAATTTTGACCATGGACTTTGTGGATGGATCAGG       GAGAAAGACAATGACTTGCACTGGGAACCAATCAGGGACCCAGCAGGTGGACAATATCTGACAGTGTC       GGCAGCCAAAGCCCCAGGGGGAAAAGCTGCACGCTTGGTGCTACCTCTCGGCCGCCTCATGCATTCAG       GGGACCTGTGCCTGTCATTCAGGCACAAGGTGACGGGGCTGCACTCTGGCACACTCCAGGTGTTTGTG       AGAAAACACGGTGCCCACGGAGCAGCCCTGTGGGGAAGAAATGGTGGCCATGGCTGGAGGCAAACACA       GATCACCTTGCGAGGGGCTGACATCAAGAGCGTCGTCTTCAAAGGTGAAAAAAGGCGTGGTCACACTG       GGGAGATTGGATTAGATGATGTGAGCTTGAAAAAAGGCCACTGCTCTGAAGAACGCGTCGACGGC                                                 NOV3b, 250095765   SEQ ID NO: 8   1588 aa   MW at 64525.3kD               Protein Sequence                     TGSMDFLLALVLVSSLYLQAAAEFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPFYVLRQR           IARIRCQLKAVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCL       NGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFR       QCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNVRGSYKCKCKEGYQGDGLT       CVYIPKVMIEPSGPIHVPKGNGTILKGDTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTP       KPTPIPTPPPPPPLPTELRTPLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFIP       RQPSNDLFEIFEIERGVSADDEAKDDPGVLVHSCNFDHGLCGWIREKDNDLHWEPIRDPAGGQYLTVS       AAKAPGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHGAHGAALWGRNGGHGWRQTQ       ITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEERVDG                                     NOV3c, 250095742   SEQ ID NO: 9   1627 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCATGGATTTTCTCCTGGCGCTGGTGCTGGTATCCTCGCTCTACCTGCAGGCGGCCGCCG           AGTTCGACGGGAGGTGGCCCAGGCAAATAGTGTCATCGATTGGCCTATGTCGTTATGGTGGGAGGATT       GACTGCTGCTGGGGCTGGGCTCGCCAGTCTTGGGGACAGTGTCAGCCTGTGTGCCAACCACGATGCAA       ACATGGTGAATGTATCGGGCCAAACAAGTGCAAGTGTCATCCTGGTTATGCTGGAAAAACCTGTAATC       AAGATCTAAATGAGTGTGGCCTGAAGCCCCGGCCCTGTAAGCACAGGTGCATGAACACTTACGGCAGC       TACAAGTGCTACTGTCTCAACGGATATATGCTCATGCCGGATGGTTCCTGCTCAAGTGCCCTGACCTG       CTCCATGGCAAACTGTCAGTATGGCTGTGATGTTGTTAAAGGACAAATACGGTGCCAGTGCCCATCCC       CTGGCCTGCACCTGGCTCCTGATGGGAGGACCTGTGTAGATGTTGATGAATGTGCTACAGGAAGAGCC       TCCTGCCCTAGATTTAGGCAATGTGTCAACACTTTTGGGAGCTACATCTGCAAGTGTCATAAAGGCTT       CGATCTCATGTATATTGGAGGCAAATATCAATGTCATGACATAGACGAATGCTCACTTGGTCAGTATC       AGTGCAGCAGCTTTGCTCGATGTTATAACGTACGTGGGTCCTACAAGTGCAAATGTAAAGAAGGATAC       CAGGGTGATGGACTGACTTGTGTGTATATCCCAAAAGTTATGATTGAACCTTCAGGTCCAATTCATGT       ACCAAAGGGAAATGGTACCATTTTAAAGGGTGACACAGGAAATAATAATTGGATTCCTGATGTTGGAA       GTACTTGGTGGCCTCCGAAGACACCATATATTCCTCCTATCATTACCAACAGGCCTACTTCTAAGCCA       ACAACAAGACCTACACCAAAGCCAACACCAATTCCTACTCCACCACCACCACCACCCCTGCCAACAGA       GCTCAGAACACCTCTACCACCTACAACCCCAGAAAGGCCAACCACCGGACTGACAACTATAGCACCAG       CTGCCAGTACACCTCCAGGAGGGATTACAGTTGACAACAGGGTACAGACAGACCCTCAGAAACCCAGA       GGAGATGTGTTCAGTGTTCTGGTACACAGTTGTAATTTTGACCATGGACTTTGTGGATGGATCAGGGA       GAAAGACAATGACTTGCACTGGGAACCAATCAGGGACCCAGCAGGTGGACAATATCTGACAGTGTCGG       CAGCCAAAGCCCCAGGGGGAAAAGCTGCACGCTTGGTGCTACCTCTCGGCCGCCTCATGCATTCAGGG       GACCTGTGCCTGTCATTCAGGCACAAGGTGACGGGGCTGCACTCTGGCACACTCCAGGTGTTTGTGAG       AAAACACGGTGCCCACGGAGCAGCCCTGTGGGGAAGAAATGGTGGCCATGGCTGGAGGCAAACACAGA       TCACCTTGCGAGGGGCTGACATCAAGAGCGTCGTCTTCAAAGGTGAAAAAAGGCGTGGTCACACTGGG       GAGATTGGATTAGATGATGTGAGCTTGAAAAAAGGCCACTGCTCTGAAGAACGCGTCGACGGC                                                 NOV3c, 250095742   SEQ ID NO: 10   542 aa   MW at 59162.3kD               Protein Sequence                     TGSMDFLLALVLVSSLYLQAAAEFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVCQPRCK           HGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTC       SMANCQYGCDVVKGQIRCQCPSPGLHIAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYTCKCHKGF       DLMYIGGKYQCHDIDECSLGQYQCSSFARCYNVRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHV       PKGNGTILKGDTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTE       LRTPLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFSVLVHSCNFDHGLCGWIRE       KDNDLHWEPIRDPAGGQYLTVSAAKAPGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVR       KHGAHGAALWGRNGGHGWRQTQITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEERVDG                                     Nov3d, 250095779   SEQ ID NO: 11   1765 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCATGGATTTTCTCCTGGCGCTGGTGCTGGTATCCTCGCTCTACCTGCAGGCGGCCGCCG           AGTTCGACGGGAGGTGGCCCAGGCAAATAGTGTCATCGATTGGCCTATGTCGTTATGGTGGGAGGATT       GACTGCTGCTGGGGCTGGGCTCGCCAGTCTTGGGGACAGTGTCAGCCTTTCTACGTCTTAAGGCAGAG       AATAGCCAGGATAAGGTGCCAGCTCAAAGCTGTGTGCCAACCACGATGCAAACATGGTGAATGTATCG       GGCCAAACAAGTGCAAGTGTCATCCTGGTTATGCTGGAAAAACCTGTAATCAAGATCTAAATGAGTGT       CAACGGATATATGCTCATGCCGGATGGTTCCTGCTCAAGTGCCCTGACCTGCTCCATGGCAAACTGTC       AGTATGGCTGTGATGTTGTTAAAGGACAAATACGGTGCCAGTGCCCATCCCCTGGCCTGCACCTGGCT       CCTGATGGGAGGACCTGTGTAGATGTTGATGAATGTGCTACAGGAAGAGCCTCCTGCCCTAGATTTAG       GCAATGTGTCAACACTTTTGGGAGCTACATCTGCAAGTGTCATAAAGGCTTCGATCTCATGTATATTG       GAGGCAAATATCAATGTCATGACATAGACGAATGCTCACTTGGTCAGTATCAGTGCAGCAGCTTTGCT       CGATGTTATAACGTACGTGGGTCCTACAAGTGCAAATGTAAAGAAGGATACCAGGGTGATGGACTGAC       TTGTGTGTATATCCCAAAAGTTATGATTGAACCTTCAGGTCCAATTCATGTACCAAAGGGAAATGGTA       CCATTTTAAAGGGTGACACAGGAAATAATAATTGGATTCCTGATGTTGGAAGTACTTGGTGGCCTCCG       AAGACACCATATATTCCTCCTATCATTACCAACAGGCCTACTTCTAAGCCAACAACAAGACCTACACC       AAAGCCAACACCAATTCCTACTCCACCACCACCACCACCCCTGCCAACAGAGCTCAGAACACCTCTAC       CACCTACAACCCCAGAAAGGCCAACCACCGGACTGACAACTATAGCACCAGCTGCCAGTACACCTCCA       GGAGGGATTACAGTTGACAACAGGGTACAGACAGACCCTCAGAAACCCAGAGGAGATGTGTTCATTCC       ACGGCAACCTTCAAATGACTTGTTTGAAATATTTGAAATAGAAAGAGGAGTCAGTGCAGACGATGAAG       CAAAGGATGATCCAGGTGTTCTGGTACACAGTTGTAATTTTGACCATGGACTTTGTGGATGGATCAGG       GAGAAGACAATGACTTGCACTGGGAACCAATCAGGGACCCAGCAGGTGGACAATAATCTGACAGTGTC       GGCAGCCAAAGCCCCAGGGGGAAAAGCTGCACGCTTGGTGCTACCTCTCGGCCGCCTCATGCATTCAG       GGGACCTGTGCCTGTCATTCAGGCACAAGGTGACGGGGCTGCACTCTGGCACACTCCAGGTGTTTGTG       AGAAAACACGGTGCCCACGGAGCAGCCCTGTGGGGAAGAAATGGTGGCCATGGCTGGAGGCAAACACA       GATCACCTTGCGAGGGGCTGACATCAAGAGCGTCGTCTTCAAAGGTGAAAAAAGGCGTGGTCACACTG       GGGAGATTGGATTAGATGATGTGAGCTTGAAAAAAGGCCACTGCTCTGAAGAAACGCGTCGACGGC                                                 NOV3d, 250095779   SEQ ID NO: 12   588 aa   MW at 64534.3kD               Protein Sequence                     TGSMDFLLALVLVSSLYLQAAAEFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPFYVLRQR           IARIRCQLKAVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCL       NGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLHLAPDGRTCVDVDECATGRASCPRFR       QCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNVRGSYKCKCKEGYQGDGLT       CVYIPKVMIEPSGPIHVPKGNGTILKGDTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTP       KPTPIPTPPPPPPLPTELRTPLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFIP       RQPSNDLFEIFEIERGVSADDEAKDDPGVLVHSCNFDHGLCGWIREKDNDLHWEPIRDPAGGQYLTVS       AAKAPGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHGAHGAALWGRNGGHGWRQTQ       ITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEERVDG                                     NOV3e, 250095794   SEQ ID NO: 13   1657 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCGAGTTCGACGGGAGGTGGCCCAGGCAAATAGTGTCATCGATTGGCCTATGTCGTTATG           GTGGGAGGATTGACTGCTGCTGGGGCTGGGCTCGCCAGTCTTGGGGACAGTGTCAGCCTGTGTGCCAA       CCACGATGCAAACATGGTGAATGTATCGGGCCAAACAAGTGCAAGTGTCATCCTGGTTATGCTGGAAA       AACCTGTAATCAAGATCTAAATGAGTGTGGCCTGAAGCCCCGGCCCTGTAAGCACAGGTGCATGAACA       CTTACGGCAGCTACAAGTGCTACTGTCTCAACGGATATATGCTCATGCCGGATGGTTCCTGCTCAAGT       GCCCTGACCTGCTCCATGGCAAACTGTCAGTATGGCTGTGATGTTGTTAAAGGACAAATACGGTGCCA       GTGCCCATCCCCTGGCCTGCACCTGGCTCCTGATGGGAGGACCTGTGTAGATGTTGATGAATGTGCTA       CAGGAAGAGCCTCCTGCCCTAGATTTAGGCAATGTGTCAACACTTTTGGGAGCTACATCTGCAAGTGT       CATAAAGGCTTCGATCTCATGTATATTGGAGGCAAATATCAATGTCATGACATAGACGAATGCTCACT       TGGTCAGTATCAGTGCAGCAGCTTTGCTCGATGTTATAACGTACGTGGGTCCTACAAGTGCAAATGTA       AAGAAGGATACCAGGGTGATGGACTGACTTGTGTGTATATCCCAAAAGTTATGATTGAACCTTCAGGT       CCAATTCATGTACCAAAGGGAAATGGTACCATTTTAAAGGGTGACACAGGAAATAATAATTGGATTCC       TGATGTTGGAAGTACTTGGTGGCCTCCGAAGACACCATATATTCCTCCTATCATTACCAACAGGCCTA       CTTCTAAGCCAACAACAAGACCTACACCAAAGCCAACACCAATTCCTACTCCACCACCACCACCACCC       CTGCCAACAGAGCTCAGAACACCTCTACCACCTACAACCCCAGAAAGGCCAACCACCGGACTGACAAC       TATAGCACCAGCTGCCAGTACACCTCCAGGAGGGATTACAGTTGACAACAGGGTACAGACAGACCCTC       AGAAACCCAGAGGAGATGTGTTCATTCCACGGCAACCTTCAAATGACTTGTTTGAAATATTTGAAATA       GAAAGAGGAGTCAGTGCAGACGATGAAGCAAAGGATGATCCAGGTGTTCTGGTACACAGTTGTAATTT       TGACCATGGACTTTGTGGATGGATCAGGGAGAAAGACAATGACTTGCACTGGGAACCAATCAGGGACC       CAGCAGGTGGACAATATCTGACAGTGTCGGCAGCCAAAGCCCCAGGGGGAAAAGCTGCACGCTTGGTG       CTACCTCTCGGCCGCCTCATGCATTCAGGGGACCTGTGCCTGTCATTCAGGCACAAGGTGACGGGGCT       GCACTCTGGCACACTCCAGGTGTTTGTGAGAAAACACGGTGCCCACGGAGCAGCCCTGTGGGGAAGAA       ATGGTGGCCATGGCTGGAGGCAAACACAGATCACCTTGCGAGGGGCTGACATCAAGAGCGTCGTCTTC       AAAGGTGAAAAAAGGCGTGGTCACACTGGGGAGATTGGATTAGATGATGTGAGCTTGAAAAAAGGCCA       CTGCTCTGAAGAACGCGTCGACGGC                                                 NOV3e, 250095794   SEQ ID NO: 14   552 aa   MW at 60397.3kD               Protein Sequence                     TGSEFDGRWPRQTVSSIGLCRYGGRIDCCWGWARQSWGQCQPVCQPRCKHGECIGPNKCKCHPGYAGK           TCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQ       CPSPGLHLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSL       GQYQCSSFARCYNVRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGNGTILKGDTGNNNWIP       DVGSTWWPPKTPYIPPITTNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELRTPLPPTTPERPTTGLTT       IAPAASTPPGGITVDNRVQTDPQKPRGDVFIPRQPSNDLFEIFEIERGVSADDEAKDDPGVLVHSCNF       DHGLCGWIREKDNDLHWEPIRDPAGGQYLTVSAAKAPGGKAARLVLPLGRLMHSGDLCLSFRHKVTGL       HSGTLQVFVRKHGAHGAALWGRNGGHGWRQTQITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGH       CSEERVDG                                     NOV3f, 250095734   SEQ ID NO: 15   1717 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCATGGATTTTCTCCTGGCGCTGGTGCTGGTATCCTCGCTCTACCTGCAGGCGGCCGCCG           AGTTCGACGGGAGTAGGTGGCCCAGGCAAATAGTGTCATCGATTGGCCTATGTCGTTATGGTGGGAGG       ATTGACTGCTGCTGGGGCTGGGCTCGCCAGTCTTGGGGACAGTGTCAGCCTGTGTGCCAACCACGATG       CAAACATGGTGAATGTATCGGGCCAAACAAGTGCAAGTGTCATCCTGGTTATGCTGGAAAAACCTGTA       ATCAAGATCTAAATGAGTGTGGCCTGAAGCCCCGGCCCTGTAAGCACAGGTGCATGAACACTTACGGC       AGCTACAAGTGCTACTGTCTCAACGGATATATGCTCATGCCGGATGGTTCCTGCTCAAGTGCCCTGAC       CTGCTCCATGGCAAACTGTCAGTATGGCTGTGATGTTGTTAAAGGACAAATACGGTGCCAGTAACCAT       CCCCTGGCCTGCACCTGGCTCCTGATGGGAGGACCTGTGTAGATGTTGATGAATGTGCTACAGGAAGA       GCCTCCTGCCCTAGATTTAGGCAATGTGTCAACACTTTTGGGAGCTACATCTGCAAGTGTCATAAAGG       CTTCGATCTCATGTATATTGGAGGCAAATATCAATGTCATGACATAGACGAATGCTCACTTGGTCAGT       ATCAGTGCAGCAGCTTTGCTCGATGTTATAACGTACGTGGGTCCTACAAGTGCAAATGTAAAGAAGGA       TACCAGGGTGATGGACTGACTTGTGTGTATATCCCAAAAGTTATGATTGAACCTTCAGGTCCAATTCA       TGTACCAAAGGGAAATGGTACCATTTTAAAGGGTGACACAGGAAATAATAATTGGATTCCTGATGTTG       GAAGTACTTGGTGGCCTCCGAAGACACCATATATTCCTCCTATCATTACCAACAGGCCTACTTCTAAG       CCAACAACAAGACCTACACCAAAGCCAACACCAATTCCTACTCCACCACCACCACCACCCCTGCCAAC       AGAGCTCAGAACACCTCTACCACCTACAACCCCAGAAAGGCCAACCACCGGACTGACAACTATAGCAC       CAGCTGCCAGTACACCTCCAGGAGGGATTACAGTTGACAACAGGGTACAGACAGACCCTCAGAAACCC       AGAGGAGATGTGTTCATTCCACGGCAACCTTCAAATGACTTGTTTGAAATATTTGAAATAGAAAGAGG       AGTCAGTGCAGACGATGAAGCAAAGGATGATCCAGGTGTTCTGGTACACAGTTGTAATTTTGACCATG       GACTTTGTGGATGGATCAGGGAGAAAGACAATGACTTGCACTGGGAACCAATCAGGGACCCAGCAGGT       GGACAATATCTGACAGTGTCGGCAGCCAAAGCCCCAGGGGGAAAAGCTGCACGCTTGGTGCTACCTCT       CGGCCGCCTCATGCATTCAGGGGACCTGTGCCTGTCATTCAGGCACAAGGTGACGGGGCTGCACTCTG       GCACACTCCAGGTGTTTGTGAGAAAACACGGTGCCCACGGAGCAGCCCTGTGGGGAAGAAATGGTGGC       CATGGCTGGAGGCAAACACAGATCACCTTGCGAGGGGCTGACATCAAGAGCGTCGTCTTCAAAGGTGA       IAAGAACGCGTCGACGGC                                                 NOV3f, 250095734   SEQ ID NO: 16   572 aa   MW at 62504.8kD               Protein Sequence                     TGSMDFLLALVLVSSLYLQAAAEFDGSRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVCQPRC           KHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALT       CSMANCQYGCDVVKGQIRCQCPSPGLHLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKG       FDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNVRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIH       VPKGNGTTLKGDTGNNNWIPDVGSTWWPPKTPYTPPIITNRPTSKPTTRPTPKPTPTPTPPPPPPLPT       ELRTPLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFIPRQPSNDLFEIFEIERG       VSADDEAKDDPGVLVHSCNFDHGLCGWIREKDNDLNWEPIRDPAGGQYLTVSAAKAPGGKAARLVLPL       GRLMHSGDLCLSFRBKVTGLHSGTLQVFVRKHGAHGAALWGRNGGHGWRQTQITLRGADIKSVVFKGE       KRRGHTGEIGLDDVSLKKGHCSEERVDG                                     NOV3g, 250095811   SEQ ID NO: 17   613 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCTGTCAGCCTGTGTGCCAACCACGATGCAAACATGGTGAATGTATCGGGCCAAACAAGT           GCAAGTGTCATCCTGGTTATGCTGGAAAAACCTGTAATCAAGATCTAAATGAGTGTGGCCTGAAGCCC       CGGCCCTGTAAGCACAGGTGCATGAACACTTACGGCAGCTACAAGTGCTACTGTCTCAACGGATATAT       GCTCATGCCGGATGGTTCCTGCTCAAGTGCCCTGACCTGCTCCATGGCAAACTGTCAGTATGGCTGTG       ATGTTGTTAAAGGACAAATACGGTGCCAGTGCCCATCCCCTGGCCTGCAGCTGGCTCCTGATGGGAGG       ACCTGTGTAGATGTTGATGAATGTGCTACAGGAAGAGCCTCCTGCCCTAGATTTAGGCAATGTGTCAA       CACTTTTGGGAGCTACATCTGCAAGTGTCATAAAGGCTTCGATCTCATGTATATTGGAGGCAAATATC       AATGTCATGACATAGACGAATGCTCACTTGGTCAGTATCAGTGCAGCAGCTTTGCTCGATGTTATAAC       GTACGTGGGTCCTACAAGTGCAAATGTAAAGAAGGATACCAGGGTGATGGACTGACTTGTGTCGACGG       C                                                 Nov3g, 250095811   SEQ ID NO: 18   204 aa   MW at 22351 .4kD               Protein Sequence                     TGSCQPVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYM           LMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVN       TFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNVRGSYKCKCKEGYQGDGLTCVDG                                             NOV3h, 250095799   SEQ ID NO: 19   613 bp               DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCTGTCAGCCTGTGTGCCAACCACGATGCAAACATGGTGAATGTATCGGGCCAAACAAGT           GCAAGTGTCATCCTGGTTATGCTGGAAAAACCTGTAATCAAGATCTAAATGAGTGTGGCCTGAAGCCC       CGGCCCTGTAAGCACAGGTGCATGAACACTTACGGCAGCTACAAGTGCTACTGTCTCAACGGATATAT       GCTCATGCCGGATGGTTCCTGCTCAAGTGCCCTGACCTGCTCCATGGCAAACTGTCAGTATGGCTGTG       ATGTTGTTAAAGGACAAATACGGTGCCAGTGCCCATCCCCTGGCCTGCACCTGGCTCCTGATGGGAGG       ACCTGTGTAGATGTTGATGAATGTGCTACAGGAAGAGCCTCCTGCCCTAGATTTAGGCAATGTGTCAA       CACTTTTGGGAGCTACATCTGCAAGTGTCATAAAGGCTTCGATCTCATGTATATTGGAGGCAAATATC       AATGTCATGACATAGACGAATGCTCACTTGGTCAGTATCAGTGCAGCAGCTTTGCTCGATGTTATAAC       GTACGTGGGTCCTACAAGTGCAAATGTAAAGAAGGATACCAGGGTGATGGACTGACTTGTGTCGACGG       C                                                 NOV3h, 250095799   SEQ ID NO: 20   204 aa   MW at 22360.4kD               Protein Sequence                     GSCQPVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYM           LMPDGSCSSALTCSMANCQYGCDWKGQIRCQCPSPGLHLAPDGRTCVDVDECATGRASCPRFRQCVN       FGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNVRGSYKCKCKEGYQGDGLTCVDG                                     NOV3i, SNP13377609 of   SEQ ID NO: 21   1882bp           CG50253-01, DNA Sequence   ORF Start: ATG at 243   ORF Stop: TAA at 1851           SNP Pos: 63   SNP Change: G to A                       GGACACTGACATGGACTGAAGGAGTAGAAAAGAAGGGAGCGGGAGGGGGCTCCGGGCGCCGC A CAGCA               GACCTACTCCGGCCGCGCGCCTCGCCGCTGTCCTCCGGGAGCGGCAGCAGTAGCCCGGGCGGCGAGGG           CTGGGGGTTCCTCGAGACTCTCAGAGGGGCGCCTCCCATCGGCGCCCACCACCCCAACCTGTTCCTCG           CGCGCCACTGCGCTGCGCCCCAGGACCCGCTGCCCAAC   ATG GATTTTCTCCTGGCGCTGGTGCTGGTA       TCCTCGCTCTACCTGCAGGCGGCCGCCGAGTTCGACGGGAGGTGGCCCAGGCAAATAGTGTCATCGAT       TGGCCTATGTCGTTATGGTGGGAGGATTGACTGCTGCTGGGGCTGGGCTCGCCAGTCTTGGGGACAGT       GTCAGCCTGTGTGCCAACCACGATGCAAACATGGTGAATGTATCGGGCCAAACAAGTGCAAGTGTCAT       CCTGGTTATGCTGGAAAAACCTGTAATCAAGATCTAAATGAGTGTGGCCTGAAGCCCCGGCCCTGTAA       GCACAGGTGCATGAACACTTACGGCAGCTACAAGTGCTACTGTCTCAACGGATATATGCTCATGCCGG       ATGGTTCCTGCTCAAGTGCCCTGACCTGCTCCATGGCAAACTGTCAGTATGGCTGTGATGTTGTTAAA       GGACAAATACGGTGCCAGTGCCCATCCCCTGGCCTGCAGCTGGCTCCTGATGGGAGGACCTGTGTAGA       TGTTGATGAATGTGCTACAGGAAGAGCCTCCTGCCCTAGATTTAGGCAATGTGTCAACACTTTTGGGA       GCTACATCTGCAAGTGTCATAAAGGCTTCGATCTCATGTATATTGGAGGCAAATATCAATGTCATGAC       ATAGACGAATGCTCACTTGGTCAGTATCAGTGCAGCAGCTTTGCTCGATGTTATAACATACGTGGGTC       CTACAAGTGCAAATGTAAAGAAGGATACCAGGGTGATGGACTGACTTGTGTGTATATCCCAAAAGTTA       TGATTGAACCTTCAGGTCCAATTCATGTACCAAAGGGAAATGGTACCATTTTAAAGGGTGACACAGGA       AATAATAATTGGATTCCTGATGTTGGAAGTACTTGGTGGCCTCCGAAGACACCATATATTCCTCCTAT       CATTACCAACAGGCCTACTTCTAAGCCAACAACAAGACCTACACCAAAGCCAACACCAATTCCTACTC       CACCACCACCACCACCCCTGCCAACAGAGCTCAGAACACCTCTACCACCTACAACCCCAGAAAGGCCA       ACCACCGGACTGACAACTATAGCACCAGCTGCCAGTACACCTCCAGGAGGGATTACAGTTGACAACAG       GGTACAGACAGACCCTCAGAAACCCAGAGGAGATGTGTTCAGTGTTCTGGTACACAGTTGTAATTTTG       ACCATGGACTTTGTGGATGGATCAGGGAGAAAGACAATGACTTGCACTGGGAACCAATCAGGGACCCA       GCAGGTGGACAATATCTGACAGTGTCGGCAGCCAAAGCCCCAGGGGGAAAAGCTGCACGCTTGGTGCT       ACCTCTCGGCCGCCTCATGCATTCAGGGGACCTGTGCCTGTCATTCAGGCACAAGGTGACGGGGCTGC       ACTCTGGCACACTCCAGGTGTTTGTGAGAAAACACGGTGCCCACGGAGCAGCCCTGTGGGGAAGAAAT       GGTGGCCATGGCTGGAGGCAAACACAGATCACCTTGCGAGGGGCTGACATCAAGAGCGTCGTCTTCAA       AGGTGAAAAAAGGCGTGGTCACACTGGGGAGATTGGATTAGATGATGTGAGCTTGAAAAAAGGCCACT       GCTCTGAAGAACGC TAA   CAACTCCAGAACTAACAATGAACTCCTAA                                           NOV3i, SNP13377609 of   SEQ ID NO: 22   536 aa   MW at 58650.8kD           CG50253-01, Protein Sequence           SNP Change: no change                     MDFLLALVLVSSLYLQAAAEFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVCQPRCKHGE           CIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMA       NCQYGCDVVKGQIRCQCPSPGLQTAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLM       YIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKG       NGTILKGDTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELRT       PLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFSVLVHSCNFDHGLCGWIREKDN       DLHWEPIRDPAGGQYLTVSAAKAPGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHG       IAHGAALWGRNGGHGWRQTQITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEER                                     NOV3j, SNP13373929 of   SEQ ID NO: 23   1882 bp           CG50253-O1, DNA Sequence   ORF Start: ATG at 243   ORE Stop: TM at 1851           SNP Pos: 226   SNP Change: A to G                       GGACACTGACATGGACTGAAGGAGTAGAAAAGAAGGGAGCGGGAGGGGGCTCCGGGCGCCGCGCAGCA               GACCTACTCCGGCCGCGCGCCTCGCCGCTGTCCTCCGGGAGCGGCAGCAGTAGCCCGGGCGGCGAGGG           CTGGGGGTTCCTCGAGACTCTCAGAGGGGCGCCTCCCATCGGCGCCCACCACCCCAACCTGTTCCTCG           CGCGCCACTGCGCTGCGCCCC G GGACCCGCTGCCCAAC   ATG GATTTTCTCCTGGCGCTGGTGCTGGTA       TCCTCGCTCTACCTGCAGGCGGCCGCCGAGTTCGACGGGAGGTGGCCCAGGCAAATAGTGTCATCGAT       TGGCCTATGTCGTTATGGTGGGAGGATTGACTGCTGCTGGGGCTGGGCTCAACAGTCTTAAGGACAGT       GTCAGCCTGTGTGCCAACCACGATGCAAACATGGTGAATGTATCGGGCCAAACAAGTGCAAGTGTCAT       CCTGGTTATGCTGGAAAAACCTGTAATCAAGATCTAAATGAGTGTGGCCTGAAGCCCCGGCCCTGTAA       GCACAGGTGCATGAACACTTACGGCAGCTACAAGTGCTACTGTCTCAACGGATATATGCTCATGCCGG       ATGGTTCCTGCTCAAGTGCCCTGACCTGCTCCATGGCAAACTGTCAGTATGGCTGTGATGTTGTTAAA       GGACAAATACGGTGCCAGTGCCCATCCCCTGGCCTGCAGCTGGCTCCTGATGGGAGGACCTGTGTAGA       TGTTGATGAATGTGCTACAGGAAGAGCCTCCTGCCCTAGATTTAGGCAATGTGTCAACACTTTTGGGA       GCTACATCTGCAAGTGTCATAAAGGCTTCGATCTCATGTATATTGGAGGCAAATATCAATGTCATGAC       ATAGACGAATGCTCACTTGGTCAGTATCAGTGCAGCAGCTTTGCTCGATGTTATAACATACGTGGGTC       CTACAAGTGCAAATGTAAAGAAGGATACCAGGGTGATGGACTGACTTGTGTGTATATCCCAAAAGTTA       TGATTGAACCTTCAGGTCCAATTCATGTACCAAAGGGAAATGGTACCATTTTAAAGGGTGACACAGGA       AATAATAATTGGATTCCTGATGTTGGAAGTACTTGGTGGCCTCCGAAGACACCATATATTCCTCCTAT       CATTACCAACAGGCCTACTTCTAAGCCAACAACAAGACCTACACCAAAGCCAACACCAATTCCTACTC       CACCACCACCACCACCCCTGCCAACAGAGCTCAGAACACCTCTACCACCTACAACCCCAGAAAGGCCA       ACCACCGGACTGACAACTATAGCACCAGCTGCCAGTACACCTCCAGGAGGGATTACAGTTGACAACAG       GGTACAGACAGACCCTCAGAAACCCAGAGGAGATGTGTTCAGTGTTCTGGTACACAGTTGTAATTTTG       ACCATGGACTTTGTGGATGGATCAGGGAGAAAGACAATGACTTGCACTGGGAACCAATCAGGGACCCA       GCAGGTGGACAATATCTGACAGTGTCGGCAGCCAAAGCCCCAGGGGGAAAAGCTGCACGCTTGGTGCT       ACCTCTCGGCCGCCTCATGCATTCAGGGGACCTGTGCCTGTCATTCAGGCACAAGGTGACGGGGCTGC       ACTCTGGCACACTCCAGGTGTTTGTGAGAAAACACGGTGCCCACGGAGCAGCCCTGTGGGGAAGAAAT       GGTGGCCATGGCTGGAGGCAAACACAGATCACCTTGCGAGGGGCTGACATCAAGAGCGTCGTCTTCAA       AGGTGAAAAAAGGCGTGGTCACACTGGGGAGATTGGATTAGATGATGTGAGCTTGAAAAAAGGCCACT       GCTCTGAAGAACGC TAA   CAACTCCAGAACTAACAATGAACTCCTAA                                           NoV3j, SNP13373929 of   SEQ ID NO: 24   536 aa   1MW at 58650.8kD           CG50253-01, Protein Sequence           SNP Change: no change                     MDFLLALVLVSSLYLQAAAEFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVCQPRCKHGE           CIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMA       NCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLM       YIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKG       NGTILKGDTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELRT       PLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFSVLVHSCNFDHGLCGWIREKDN       DLHWEPIRDPAGGQYLTVSAAKAPGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHG       AHGAALWGRNGGHGWRQTQITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEER                                     NOV3k, SNP13380272 of   SEQ ID NO: 25   1882 bp           CG50253-01, DNA Sequence   ORF Start: ATG at 243   ORF Stop: TM at 1851           SNP Pos: 719   SNP Change: G to C                       GGACACTGACATGGACTGAAGGAGTAGAAAAGAAGGGAGCGGGAGGGGGCTCCGGGCGCCGCGCAGCA               GACCTACTCCGGCCGCGCGCCTCGCCGCTGTCCTCCGGGAGCGGCAGCAGTAGCCCGGGCGGCGAGGG           CTGGGGGTTCCTCGAGACTCTCAGAGGGGCGCCTCCCATCGGCGCCCACCACCCCAACCTGTTCCTCG           CGCGCCACTGCGCTGCGCCCCAGGACCCGCTGCCCAAC   ATG GATTTTCTCCTGGCGCTGGTGCTGGTA       TCCTCGCTCTACCTGCAGGCGGCCGCCGAGTTCGACGGGAGGTGGCCCAGGCAAATAGTGTCATCGAT       TGGCCTATGTCGTTATGGTGGGAGGATTGACTGCTGCTGGGGCTGGGCTCGCCAGTCTTGGGGACAGT       GTCAGCCTGTGTGCCAACCACGATGCAAACATGGTGAATGTATCGGGCCAAACAAGTGCAAGTGTCAT       CCTGGTTATGCTGGAAAAACCTGTAATCAAGATCTAAATGAGTGTGGCCTGAAGCCCCGGCCCTGTAA       GCACAGGTGCATGAACACTTACGGCAGCTACAAGTGCTACTGTCTCAACGGATATATGCTCATGCCGG       ATGGTTCCTGCTCAAGTGCCCTGACCTGCTCCATGGCAAACTGTCAGTATGGCTGTGATGTTGTTAAA       GGACAAATACGGTGCCAGTGCCCATCCCCTGGCCTGCAC   C   TGGCTCCTGATGGGAGGACCTGTGTAGA       TGTTGATGAATGTGCTACAGGAAGAGCCTCCTGCCCTAGATTTAGGCAATGTGTCAACACTTTTGGGA       GCTACATCTGCAAGTGTCATAAAGGCTTCGATCTCATGTATATTGGAGGCAAATATCAATGTCATGAC       ATAGACGAATGCTCACTTGGTCAGTATCAGTGCAGCAGCTTTGCTCGATGTTATAACATACGTGGGTC       CTACAAGTGCAAATGTAAAGAAGGATACCAGGGTGATGGACTGACTTGTGTGTATATCCCAAAAGTTA       TGATTGAACCTTCAGGTCCAATTCATGTACCAAAGGGAAATGGTACCATTTTAAAGGGTGACACAGGA       AATAATAATTGGATTCCTGATGTTGGAAGTACTTGGTGGCCTCCGAAGACACCATATATTCCTCCTAT       CATTACCAACAGGCCTACTTCTAAGCCAACAACAAGACCTACACCAAAGCCAACACCAATTCCTACTC       CACCACCACCACCACCCCTGCCAACAGAGCTCAGAACACCTCTACCACCTACAACCCCAGAAAGGCCA       ACCACCGGACTGACAACTATAGCACCAGCTGCCAGTACACCTCCAGGAGGGATTACAGTTGACAACAG       GGTACAGACAGACCCTCAGAAACCCAGAGGAGATGTGTTCAGTGTTCTGGTACACAGTTGTAATTTTG       ACCATGGACTTTGTGGATGGATCAGGGAGAAAGACAATGACTTGCACTGGGAACCAATCAGGAACCCA       GCAGGTGGACAATATCTGACAGTGTCGGCAGCCAAAGCCCCAGGGGGAAAAGCTGCACGCTTGGTGCT       ACCTCTCGGCCGCCTCATGCATTCAGGGGACCTGTGCCTGTCATTCAGGCACAAGGTGACGGGGCTGC       ACTCTGGCACACTCCAGGTGTTTGTGAGAAAACACGGTGCCCACGGAGCAGCCCTGTGGGGAAGAAAT       GGTGGCCATGGCTGGAGGCAAACACAGATCACCTTGCGAGGGGCTGACATCAAGAGCGTCGTCTTCAA       AGGTGAAAAAAGGCGTGGTCACACTGGGGAGATTGGATTAGATGATGTGAGCTTGAAAAAAGGCCACT       GCTCTGAAGAACGC TAA   CAACTCCAGAACTAACAATGAACTCCTAA                                           NOV3k, SNP13380272 of   SEQ ID NO: 26   536 aa   MW at 58659.8kD           CG50253-01, Protein Sequence   SNP Pos: 159   SNP Change: Gln to His                     MDFLLALVLVSSLYLQAAAEFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVCQPRCKHGE           CIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMA       NCQYGCDVVKGQIRCQCPSPGL   H   LAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLM       YIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKG       NGTILKGDTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELRT       PLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFSVLVHSCNFDHGLCGWIREKDN       DLHWEPIRDPAGGQYLTVSAAKAPGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHG       AHGAALWGRNGGHGWRQTQITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEER                                     Nov3l, SNP13379745 of   SEQ ID NO: 27   1882 bp           CG50253-01, DNA Sequence   ORF Start: ATG at 243   ORF Stop: TAA at 1851           SNP Pos: 750   SNP Change: G to A                       GGACACTGACATGGACTGAAGGAGTAGAAAAGAAGGGAGCGGGAGGGGGCTCCGGGCGCCGCGCAGCA               GACCTACTCCGGCCGCGCGCCTCGCCGCTGTCCTCCGGGAGCGGCAGCAGTAGCCCGGGCGGCGAGGC           CTGGGGGTTCCTCGAGACTCTCAGAGGGGCGCCTCCCATCGGCGCCCACCACCCCAACCTGTTCCTCG           CGCGCCACTGCGCTGCGCCCCAGGACCCGCTGCCCAAC   ATG GATTTTCTCCTGGCGCTGGTGCTGGTA       TCCTCGCTCTACCTGCAGGCGGCCGCCGAGTTCGACGGGAGGTGGCCCAGGCAAATAGTGTCATCGAT       TGGCCTATGTCGTTATGGTGGGAGGATTGACTGCTGCTGGGGCTGGGCTCGCCAGTCTTGGGGACAGT       GTCAGCCTGTGTGCCAACCACGATGCAAACATGGTGAATGTATCGGGCCAAACAAGTGCAAGTGTCAT       CCTGGTTATGCTGGAAAAACCTGTAATCAAGATCTAAATGAGTGTGGCCTGAAGCCCCGGCCCTGTAA       GCACAGGTGCATGAACACTTACGGCAGCTACAAGTGCTACTGTCTCAACGGATATATGCTCATGCCGG       ATGGTTCCTGCTCAAGTGCCCTGACCTGCTCCATGGCAAACTGTCAGTATGGCTGTGATGTTGTTAAA       GGACAAATACGGTGCCAGTGCCCATCCCCTGGCCTGCAGCTGGCTCCTGATGGGAGGACCTGTGTAGA       T   A   TTGATGAATGTGCTACAGGAAGAGCCTCCTGCCCTAGATTTAGGCAATGTGTCAACACTTTTGGGA       GCTACATCTGCAAGTGTCATAAAGGCTTCGATCTCATGTATATTGGAGGCAAATATCAATGTCATGAC       ATAGACGAATGCTCACTTGGTCAGTATCAGTGCAGCAGCTTTGCTCGATGTTATAACATACGTGGGTC       CTACAAGTGCAAATGTAAAGAAGGATACCAGGGTGATGGACTGACTTGTGTGTATATCCCAAAAGTTA       TGATTGAACCTTCAGGTCCAATTCATGTACCAAAGGGAAATGGTACCATTTTAAAGGGTGACACAGGA       AATAATAATTGGATTCCTGATGTTGGAAGTACTTGGTGGCCTCCGAAGACACCATATATTCCTCCTAT       CATTACCAACAGGCCTACTTCTAAGCCAACAACAAGACCTACACCAAAGCCAACACCAATTCCTACTC       CACCACCACCACCACCCCTGCCAACAGAGCTCAGAACACCTCTACCACCTACAACCCCAGAAAGGCCA       ACCACCGGACTGACAACTATAGCACCAGCTGCCAGTACACCTCCAGGAGGGATTACAGTTGACAACAG       GGTACAGACAGACCCTCAGAAACCCAGAGGAGATGTGTTCAGTGTTCTGGTACACAGTTGTAATTTTG       ACCATGGACTTTGTGGATGGATCAGGGAGAAAGACAATGACTTGCACTGGGAACCAATCAGGGACCCA       GCAGGTGGACAATATCTGACAGTGTCGGCAGCCAAAGCCCCAGGGGGAAAAGCTGCACGCTTGGTGCT       ACCTCTCGGCCGCCTCATGCATTCAGGGGACCTGTGCCTGTCATTCAGGCACAAGGTGACGGGGCTGC       ACTCTGGCACACTCCAGGTGTTTGTGAGAAAACACGGTGCCCACGGAGCAGCCCTGTGGGGAAGAAAT       GGTGGCCATGGCTGGAGGCAAACACAGATCACCTTGCGAGGGGCTGACATCAAGAGCGTCGTCTTCAA       AGGTGAAAAAAGGCGTGGTCACACTGGGGAGATTGGATTAGATGATGTGAGCTTGAAAAAAGGCCACT       GCTCTGAAGAACGC TAA   CAACTCCAGAACTAACAATGAACTCCTAA                                           NOV3l, SNP13379745 of   SEQ ID NO: 28   536 aa   MW at 58664.8kD           CG50253-01, Protein Sequence   SNP Pos: 170   SNP Change: Val to Ile                     MDFLLALVLVSSLYLQAAAEFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVCQPRCKHGE           CIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMA       NCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVD   I   DECATGRASCPRFRQCVNTFGSYICKCHKGFDLM       YIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKG       NGTILKGDTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELRT       PLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFSVLVHSCNFDHGLCGWIREKDN       DLNWEPIRDPAGGQYLTVSAAKAPGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHG       AHGAALWGRNGGHGWRQTQITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEER                                     NOV3m, SNP13373930 of   SEQ ID NO: 29   1882 bp           CG50253-01, DNA Sequence   ORF Start: ATG at 243   ORF Stop: TAA at 1851           SNP Pos: 942   SNP Change: A to G                       GGACACTGACATGGACTGAAGGAGTAGAAAAGAAGGGAGCGGGAGGGGGCTCCGGGCGCCGCGCAGCA               GACCTACTCCGGCCGCGCGCCTCGCCGCTGTCCTCCGGGAGCGGCAGCAGTAGCCCGGGCGGCGAGGG           CTGGGGGTTCCTCGAGACTCTCAGAGGGGCGCCTCCCATCGGCGCCCACCACCCCAACCTGTTCCTCG           CGCGCCACTGCGCTGCGCCCCAGGACCCGCTGCCCAAC   ATG GATTTTCTCCTGGCGCTGGTGCTGGTA       TCCTCGCTCTACCTGCAGGCGGCCGCCGAGTTCGACGGGAGGTGGCCCAGGCAAATAGTGTCATCGAT       TGGCCTATGTCGTTATGGTGGGAGGATTGACTGCTGCTGGGGCTGGGCTCGCCAGTCTTGGGGACAGT       GTCAGCCTGTGTGCCAACCACGATGCAAACATGGTGAATGTATCGGGCCAAACAAGTGCAAGTGTCAT       CCTGGTTATGCTGGAAAAACCTGTAATCAAGATCTAAATGAGTGTGGCCTGAAGCCCCGGCCCTGTAA       GCACAGGTGCATGAACACTTACGGCAGCTACAAGTGCTACTGTCTCAACGGATATATGCTCATGCCGG       ATGGTTCCTGCTCAAGTGCCCTGACCTGCTCCATGGCAAACTGTCAGTATGGCTGTGATGTTGTTAAA       GGACAAATACGGTGCCAGTGCCCATCCCCTGGCCTGCAGCTGGCTCCTGATGGGAGGACCTGTGTAGA       TGTTGATGAATGTGCTACAGGAAGAGCCTCCTGCCCTAGATTTAGGCAATGTGTCAACACTTTTGGGA       GCTACATCTGCAAGTGTCATAAAGGCTTCGATCTCATGTATATTGGAGGCAAATATCAATGTCATGAC       ATAGACGAATGCTCACTTGGTCAGTATCAGTGCAGCAGCTTTGCTCGATGTTATAAC   G   TACGTGGGTC       CTACAAGTGCAAATGTAAAGAAGGATACCAGGGTGATGGACTGACTTGTGTGTATATCCCAAAAGTTA       TGATTGAACCTTCAGGTCCAATTCATGTACCAAAGGGAAATGGTACCATTTTAAAGGGTGACACAGGA       AATAATAATTGGATTCCTGATGTTGGAAGTACTTGGTGGCCTCCGAAGACACCATATATTCCTCCTAT       CATTACCAACAGGCCTACTTCTAAGCCAACAACAAGACCTACACCAAAGCCAACACCAATTCCTACTC       CACCACCACCACCACCCCTGCCAACAGAGCTCAGAACACCTCTACCACCTACAACCCCAGAAAGGCCA       ACCACCGGACTGACAACTATAGCACCAGCTGCCAGTACACCTCCAGGAGGGATTACAGTTGACAACAG       GGTACAGACAGACCCTCAGAAACCCAGAGGAGATGTGTTCAGTGTTCTGGTACACAGTTGTAATTTTG       ACCATGGACTTTGTGGATGGATCAGGGAGAAAGACAATGACTTGCACTGGGAACCAATCAGGGACCCA       GCAGGTGGACAATATCTGACAGTGTCGGCAGCCAAAGCCCCAGGGGGAAAAGCTGCACGCTTGGTGCT       ACCTCTCGGCCGCCTCATGCATTCAGGGGACCTGTGCCTGTCATTCAGGCACAAGGTGACGGGGCTGC       ACTCTGGCACACTCCAGGTGTTTGTGAGAAAACACGGTGCCCACGGAGCAGCCCTGTGGGGAAGAAAT       GGTGGCCATGGCTGGAGGCAAACACAGATCACCTTGCGAGGGGCTGACATCAAGAGCGTCGTCTTCAA       AGGTGAAAAAAGGCGTGGTCACACTGGGGAGATTGGATTAGATGATGTGAGCTTGAAAAAAGGCCACT       GCTCTGAAGAACGC TAA   CAACTCCAGAACTAACAATGAACTCCTAA                                           NOV3m, SNP13373930 of   SEQ ID NO: 30   536 aa   MW at 58636.8kD           CG50253-01, Protein Sequence   SNP Pos: 234   SNP Change: Ile to Val                     MDFLLALVLVSSLYLQAAAEFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVCQPRCKHGE   +TL,42       CIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMA       NCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLM       YIGGKYQCHDIDECSLGQYQCSSFARCYNVRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKG       NGTILKGDTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELRT       PLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFSVLVHSCNFDHGLCGWIREKDN       DLHWEPIRDPAGGQYLTVSAAKAPGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHG       AHGAALWGRNGGHGWRQTQITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEER                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 3B.  
               TABLE 3B                       Comparison of the NOV3 protein sequences.                                            NOV3a   ---MDFLLALVLVSSLYLQAAAEFDG-RWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQC           NOV3b   TGSMDFLLALVLVSSLYLQAAAEFDG-RWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQC       NOV3c   TGSMDFLLALVLVSSLYLQAAAEFDG-RWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQC       NOV3d   TGSMDFLLALVLVSSLYLQAAAEFDG-RWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQC       NOV3e   -------------------TGSEFDG-RWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQC       NOV3f   TGSMDFLLALVLVSSLYLQAAAEFDGSRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQC       NOV3g   --------------------------------------------------------TGSC       NOV3h   --------------------------------------------------------TGSC               NOV3a   QP-----------------VCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRP       NOV3b   QPFYVLRQRTARIRCQLKAVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRP       NOV3c   QP-----------------VCQPRCKHGECTGPNKCKCHPGYAGKTCNQDLNECGLKPRP       NOV3d   QPFYVLRQRIAPTRCQLKAVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRP       NOV3e   QP-----------------VCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRP       NOV3f   QP-----------------VCQPRCKHGECIGPNXCKCHPGYAGKTCNQDLNECGLKPRP       NOV3g   QP-----------------VCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRP       NOV3h   QP-----------------VCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRP               NOV3a   CKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQ       NOV3b   CKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQ       NOV3c   CKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLH       NOV3d   CKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLH       NOV3e   CKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLH       NOV3f   CKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLH       NOV3g   CKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQ       NOV3h   CKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLH               NOV3a   LAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDTDECS       NOV3b   LAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECS       NOV3c   LAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECS       NOV3d   LAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECS       NOV3e   LAPDGRTCVDVDECATGPASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECS       NOV3f   LAPDGRTCVDVDECATGPASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECS       NOV3g   LAPDGRTCVDVDECATGHASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECS       NOV3h   LAPDGRTCVDVDECATGHASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECS               NOV3a   LGQYQCSSFARCYNIRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGNGTILKG       NOV3b   LGQYQCSSFARCYNVRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGNGTILKG       NOV3c   LGQYQCSSFARCYNVRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGNGTILKG       NOV3d   LGQYQCSSFARCYNVRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGNGTILKG       NOV3e   LGQYQCSSFARCYNVRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGNGTILKG       NOV3f   LGQYQCSSFARCYNVRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGNGTILKG       NOV3g   LGQYQCSSFARCYNVRGSYKCKCKEGYQGDGLTCVDG-----------------------       NOV3h   LGQYQCSSFARCYNVRGSYKCKCKEGYQGDGLTCVDG-----------------------               NOV3a   DTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELR       NOV3b   DTGNNNWIPDVGSTWWPPKTPYIPPTITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELR       NOV3c   DTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELR       NOV3d   DTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELR       NOV3e   DTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELR       NOV3f   DTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELR       NOV3g   ------------------------------------------------------------       NOV3h   ------------------------------------------------------------               NOV3a   TPLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFS------------       NOV3b   TPLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFTPRQPSNDLFEIF       NOV3c   TPLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFS------------       NOV3d   TPLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFTPRQPSNDLFEIF       NOV3e   TPLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFTPRQPSNDLFEIF       NOV3f   TPLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFTPRQPSNDLFEIF       NOV3g   ------------------------------------------------------------       NOV3h   ------------------------------------------------------------               NOV3a   -----------------VLVHSCNFDHGLCGWIREKDNDLHWEPIPDPAGGQYLTVSAAK       NOV3b   EIERGVSADDEAKDDPGVLVHSCNFDHGLCGWIREKDNDLHWEPIPDPAGGQYLTVSAAK       NOV3c   -----------------VLVHSCNFDHGLCGWIREKDNDLHWEPIRDPAGGQYLTVSAAK       NOV3d   EIERGVSADDEAKDDPGVLVHSCNFDHGLCGWIREKDNDLHWEPIRDPAGGQYLTVSAAK       NOV3e   EIERGVSADDEAKDDPGVLVHSCNFDHGLCGWIREKDNDLHWEPIRDPAGGQYLTVSAAK       NOV3f   EIERGVSADDEAKDDPGVLVHSCNFDHGLCGWIREKDNDLHWEPIRDPAGGQYLTVSAAK       NOV3g   ------------------------------------------------------------       NOV3h   ------------------------------------------------------------               NOV3a   APGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHGAHGAALWGRNGGHG       NOV3b   APGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHGAHGAALWGRNGGHG       NOV3c   APGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHGAHGAALWGRNGGHG       NOV3d   APGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHGAHGAALWGRNGGHG       NOV3e   APGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHGAHGAALWGRNGGHG       NOV3f   APGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHGAHGAALWGRNGGHG       NOV3g   ------------------------------------------------------------       NOV3h   ------------------------------------------------------------               NOV3a   WRQTQITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEER---       NOV3b   WRQTQITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEERVDG       NOV3c   WRQTQITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEERVDG       NOV3d   WRQTQITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEERVDG       NOV3e   WRQTQITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEERVDG       NOV3f   WRQTQITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEERVDG       NOV3g   -------------------------------------------------       NOV3h   -------------------------------------------------               NOV3a   (SEQ ID NO: 6)       NOV3b   (SEQ ID NO: 8)       NOV3c   (SEQ ID NO: 10)       NOV3d   (SEQ ID NO: 12)       NOV3e   (SEQ ID NO: 14)       NOV3f   (SEQ ID NO: 16)       NOV3g   (SEQ ID NO: 18)       NOV3h   (SEQ ID NO: 20)                  
 
      Further analysis of the NOV3a protein yielded the following properties shown in Table 3C.  
               TABLE 3C                       Protein Sequence Properties NOV3a                                        SignalP analysis:   Cleavage site between residues 20 and 21       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 2; pos. chg 0; neg. chg 1           H-region:   length 17; peak value 0.00           PSG score:   −4.40                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −0.34           possible cleavage site: between 17 and 18                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 3-19               −4.19                             PERIPHERAL   Likelihood = 5.67 (at 439)                         ALOM score: −4.19 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 10           Charge difference: 0.0 C(0.0)-N(0.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 2 (cytoplasmic tail 1 to 3)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:    0   Hyd Moment(75):   4.41           Hyd Moment(95):    7.23   G content:   0           D/E content:    2   S/T content:   2                         Score: −6.55       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 11.9%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         43.5%: nuclear           26.1%: mitochondrial            8.7%: cytoplasmic            4.3%: plasma membrane            4.3%: vesicles of secretory system            4.3%: extracellular, including cell wall            4.3%: endoplasmic reticulum            4.3%: peroxisomal                 &gt;&gt; prediction for CG50253-01 is nuc (k = 23)                  
 
      A search of the NOV3a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 3D.  
               TABLE 3D                          Geneseq Results for NOV3a                                         NOV3a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               ABG70290   Human novel polypeptide #6 -  Homo     1 . . . 536    536/536 (100%)   0.0             sapiens , 536 aa. [WO200257452-A2,   1 . . . 536    536/536 (100%)           25-JUL-2002]       ABG69659   Human secreted protein SCEP-39 -   1 . . . 536   534/566 (94%)   0.0             Homo sapiens , 566 aa.   1 . . . 566   535/566 (94%)           [WO200248337-A2, 20-JUN-2002]       AAB70547   Human PRO17 protein sequence SEQ   1 . . . 536   532/582 (91%)   0.0           ID NO: 34 -  Homo sapiens , 582 aa.   1 . . . 582   533/582 (91%)           [WO200110902-A2, 15-FEB-2001]       AAB70549   Clone 16467945.0.85-S261.D protein   20 . . . 536    512/546 (93%)   0.0           sequence SEQ ID NO: 82 -  Homo     1 . . . 546   514/546 (93%)             sapiens , 546 aa. [WO200110902-A2,           15-FEB-2001]       ABU58425   Human PRO polypeptide #26 -  Homo     1 . . . 505   503/505 (99%)   0.0             sapiens , 509 aa. [US2003027272-A1,   1 . . . 505   504/505 (99%)           06-FEB-2003]                  
 
      In a BLAST search of public sequence databases, the NOV3a protein was found to have homology to the proteins shown in the BLASTP data in Table 3E.  
               TABLE 3E                          Public BLASTP Results for NOV3a                                         NOV3a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               CAC33425   Sequence 33 from Patent   1 . . . 536   532/582 (91%)   0.0           WO0110902 -  Homo sapiens     1 . . . 582   533/582 (91%)           (Human), 582 aa.       Q91V88   POEM (NEPHRONECTIN short   1 . . . 532   470/562 (83%)   0.0           isoform) -  Mus musculus  (Mouse),   1 . . . 561   497/562 (87%)           561 aa.       Q91ZD3   Nephronectin long isoform -  Mus     1 . . . 532   470/579 (81%)   0.0             musculus  (Mouse), 578 aa.   1 . . . 578   497/579 (85%)       Q91XL5   Nephronectin -  Mus musculus     1 . . . 532   470/593 (79%)   0.0           (Mouse), 592 aa.   1 . . . 592   497/593 (83%)       Q923T5   Nephronectin -  Mus musculus     1 . . . 532   470/610 (77%)   0.0           (Mouse), 609 aa.   1 . . . 609   497/610 (81%)                  
 
      PFam analysis predicts that the NOV3a protein contains the domains shown in the Table 3F.  
               TABLE 3F                          Domain Analysis of NOV3a                                                     Identities/                           Similarities for           Pfam   NOV3a       the Matched   Expect           Domain   Match Region       Region   Value                                                     C_tripleX   54 . . . 71    7/18   (39%)   0.24                   15/18   (83%)           EGF   60 . . . 86    13/47   (28%)   0.13                   23/47   (49%)           EGF   93 . . . 127   15/47   (32%)   0.51                   27/47   (57%)           EGF   133 . . . 167    10/47   (21%)   0.035                   24/47   (51%)           EGF   218 . . . 253    12/47   (26%)   0.00011                   28/47   (60%)           MAM   393 . . . 534    48/183   (26%)   8.6e−27                   98/183   (54%)                      
 
     Example 4  
      The NOV4 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 4A.  
               TABLE 4A                       NOV4 Sequence Analysis                                                        NOV4a, CG50377-04   SEQ ID NO: 31   10655 bp               DNA Sequence   ORF Start: at 1   ORF Stop: TAG at 10639                     GGCCAGAACTGCACGTTCCAACTGCACGGTCCCAATGGGACAGTTGAGAGCCCAGGGTTCCCATATGG           CTACCCCAATTACGCCAACTGCACGTGGACCATCACCGCGGAAGAGCAGCACAGAATCCAGCTTGTGT       TCCAGTCCTTTGCCCTGGAAGAGGACTTTGATGTCCTGTCGGTGTTTGATGGTCCACCCCAGCCAGAG       AATCTGCGTACGAGGCTCACAGGCTTTCAGCTGCCAGCCACCATTGTTAGTGCAGCCACCACCCTCTC       TCTGCGCCTCATCAGCGACTATGCAGTCAGTGCCCAAGGCTTCCACGCCACCTATGAAGTTCTCCCCA       GCCACACATGTGGGAACCCAGGGAGGCTGCCCAATGGCATCCAGCAGGGTTCAACCTTCAACCTCGGT       GACAAGGTCCGCTACAGCTGCAACCTTGGCTTCTTCCTGGAGGGCCACGCCGTGCTCACCTGCCACGC       TGGCTCTGAGAACAGCGCCACGTGGGACTTCCCCCTGCCTTCCTGCAGAGCTGATGATGCCTGTGGTG       GGACCCTGCGGGGCCAGAGTGGCATCATCTCCAGCCCCCACTTCCCCTCGGAGTACCATAACAATGCC       GACTGCACATGGACCATCCTGGCTGAGCTGGGGGACACCATCGCCCTGGTGTTTATTGACTTCCAGCT       GGAGGATGGTTACGACTTTCTGGAAGTCACTGGGACAGAAGGCTCCTCCCTCTGGTTCACCGGAGCCA       GCCTCCCAGCCCCCGTTATCAGCAGCAAGAACTGGCTGCGACTGCACTTCACATCGGATGGCAACCAC       CGGCAGCGCGGATTCAGTGCCCAATACCAAGTCAAGAAGCAAATTGAGTTGAAGTCTCGAGGTGTGAA       GCTGATGCCCAGCAAAGACAACAGCCAGAAGACGTCTGTGGTAACTCAGGTTGGTGTGTCCCAAGGAC       ATAATATGTGTCCAGACCCTGGCATACCCGAAAGGGGCAAAAGACTAGGCTCGGATTTCAGGTTAGGA       TCCAGCGTCCAGTTCACCTGCAACGAGGGCTATGACCTGCAAGGGTCCAAGCGGATCACCTGTATGAA       AGTGAGCGACATGTTTGCGGCCTGGAGCGACCACAGGCCAGTCTGCCGAGCCCGCATGTGTGATGCCC       ACCTTCGAGGCCCCTCGGGCATCATCACCTCCCCCAATTTCCCCATTCAGTATGACAACAATGCACAC       TGTGTGTGGATCATCACAGCACTCAACCCCTCCAAGGTAATCAAGCTCGCCTTTGAGGAGTTTGATTT       GGAGAGGGGCTATGACACCCTGACGGTCGGTGATGGTGGTCAGGATGGGGACCAGAAGACAGTTCTCT       ACATGCTGACAGGTACATCGGTCCCGGATCTCATTGTCAGCACCAATCATCAAATGTGGCTCCTCTTC       CAGACTGATGGCAGTGGCAGTTCCCTGGGATTCAAGGCTTCTTATGAAGAGATCGAGCAGGGCAGTTG       CGGTGACCCTGGCATACCTGCATATGGCCGGAGGGAAGGCTCCCGGTTTCGCCACGGTGACACACTCA       AGTTTGAGTGCCAGCCCGCCTTTGAGCTGGTGGGACAGAAGGCAATCACATGCCAAAAGAATAACCAA       TGGTCGGCTAAGAAGCCAGGCTGCGTGTGTTCCTGCTTCTTCAACTTCACCAGCCCGTCTGGGGTTGT       CCTGTCTCCCAACTACCCAGAGGACTATGGCAACCACCTCCACTGTGTCTGGCTCATCCTGGCCAGGC       CTGAGAGCCGCATCCACCTGGCCTTCAACGACATTGACGTGGAGCCTCAGTTTGATTTCCTGGTCATC       AAGGATGGGGCCACCGCCGAGGCGCCCGTCCTGGGCACCTTCTCAGGAAACCAGCTTCCCTCCTCCAT       CACAAGCAGTGGCCACGTGGCCCGTCTCGAGTTCCAGACTGACCACTCCACAGGGAAGAGGGGCTTCA       ACATCACTTTTACCAGTGAGTCCTCCAACGAGTGCCCGGATCCTGGCGTTCCAGTAAATGGCAAACGG       TTTGGGGACAGCCTCCAGCTGGGCAGCTCCATCTCCTTCCTCTGTGATGAAGGCTTCCTTGGGACTCA       GGGCTCAGAGACCATCACCTGCGTCCTGAAGGAGGGCAGCGTGGTCTGGAACAGCGCTGTGCTGCGGT       GTGAAGCTCCCTGTGGTGGTCACCTGACTTCGCCCAGCGGCACCATCCTCTCTCCGGGCTGGCCTGGC       TTCTACAAGGATGCCTTGAGCTGTGCCTGGGTGATTGAGGCCCAGCCAGGCTACCCCATCAAAATCAC       CTTCGACAGGTTCAAAACCGAGGTCAACTATGACACCCTGGAAGTACGCGATGGGCGGACTTACTCAG       CGCCCTTGATCGGGGTTTACCACGGGACCCAGGTTCCCCAGTTCCTCATCAGCACCAGCAACTACCTC       TACCTCCTCTTCTCTACCGACAAGAGTCACTCGGACATCGGCTTCCAGCTCCGCTATGAGGCTATAAC       ACTGCAGTCAGACCACTGTCTGGATCCAGGAATCCCAGTAAATGGACAGCGTCATGGGAATGACTTCT       ACGTGGGCGCGCTGGTGACCTTCAGCTGTGACTCGGGCTACACATTAAGTGACGGGGAGCCTCTGGAG       TGTGAGCCCAACTTCCAGTGGAGCCGGGCCCTGCCCAGTTGTGAAGCTCTCTGTGGTGGCTTCATTCA       AGGCTCCAGTGGGACCATCTTGTCGCCAGGTTTCCCTGACTTCTACCCCAACAACTTGAACTGCACCT       GGATTATCGAAACATCTCATGGCAAGGGTGTGTTCTTCACTTTCCACACCTTCCACCTGGAAAGTGGC       CATGACTACCTCCTCATCACTGAGAACGGCAGCTTCACCCAGCCCCTGAGGCAGCTAACTGGATCTCG       GCTGCCAGCTCCCATCAGCGCTGGGCTCTATGGCAACTTCACTGCCCAGGTCCGCTTCATCTCTGATT       TCTCCATGTCATATGAAGGATTCAACATCACCTTCTCAGAGTACGACTTGGAGCCCTGTGAGGAGCCC       GAGGTCCCAGCCTACAGCATCCGGAAGGGCTTGCAGTTTGGCGTGGGCGACACCTTGACCTTCTCCTG       CTTCCCCGGGTACCGTCTGGAGGGCACCGCCCGCATCACGTGCCTGGGGGGCAGACGGCGCCTGTGGA       GCTCGCCTCTGCCAAGGTGTGTTGCTGAGTGTGGGAATTCAGTCACAGGCACTCAGGGTACTTTGCTG       TCCCCCAACTTTCCTGTGAACTACAATAACAATCATGAATGCATCTACTCCATCCAGACCCAGCCAGG       GAAGGGAATTCAGCTGAAAGCCAGGGCATTCGAACTCTCCGAAGGAGATGTCCTCAAGGTTTATGATG       GCAACAACAACTCCGCCCGTTTGCTGGGAGTTTTTAGCCATTCTGAGATGATGGGGGTGACTTTGAAC       AGCACATCCAGCAGTCTGTGGCTTGATTTCATCACTGATGCTGAAAACACCAGCAAGGGCTTTGAACT       GCACTTTTCCAGTTTTGAACTCATCAAATGTGAGGACCCAGGAACCCCCAAGTTTGGCTACAAGGTTC       ATGATGAAGGTCATTTTGCAGGGAGCTCCGTGTCCTTCAGCTGTGACCCTGGATACAGCCTGCGGGGT       AGTGAGGAGCTGCTGTGTCTGAGTGGAGAGCGCCGGACCTGGGACCGGCCTCTGCCCACCTGTGTCGC       CGAGTGTGGAGGGACAGTGAGAGGAGAGGTGTCGGGGCAGGTGCTGTCACCCGGGTATCCAGCTCCCT       ATGAACACAATCTCAACTGCATCTGGACCATCGAAGCAGAGGCCGGCTGCACCATTGGGCTACACTTC       CTGGTGTTTGACACAGAGGAGGTTCACGACGTGCTGCGCATCTGGGATGGGCCTGTGGAGAGCGGGGT       TCTGCTGAAGGAGCTGAGTGGCCCGGCCCTGCCCAAGGACCTGCATAGCACCTTCAACTCGGTCGTCC       TGCAGTTCAGCACTGACTTCTTCACCAGCAAGCAGGGCTTTGCCATTCAATTTTCAGGTTCCACAGCA       ACGTCCTGCAATGACCCTGGGATCCCGCAGAATGGGAGTCGGAGTGGTGACAGTTGGGAAGCCGGCGA       CTCCACAGTGTTCCAGTGTGACCCTGGCTACGCGCTGCAGGGAAGTGCAGAGATCAGCTGTGTGAAGA       TCGAGAACAGGTTCTTCTGGCAGCCCAGCCCGCCAACATGCATCGCTCCCTGCGGGGGAGACCTGACA       GGACCATCTGGAGTCATCCTCTCACCAAATTACCCAGAACCCTACCCGCCAGGCAAGGAGTGTGACTG       GAAAGTGACCGTCTCACCAGACTACGTCATCGCCCTGGTATTGTTCCCCAGCTTTAACCTGGAGCCTG       GCTATGACTTCCTCCATATCTACGACGGACGGGACTCTCTCAGCCCTCTCATAGGAAGCTTCTATGGC       TCCCAGCTCCCAGGCCGCATTGAAAGCAGCAGCAACAGCCTCTTCCTCGCCTTCCGCAGCGATGCATC       TGTGAGCAATGCTGGCTTCGTCATTGACTTCCCAGAAAACCCGCGGGAGTCATGTTTTGATCCTGGTT       CCATCAAGAACGGCACACGGGTGGGGTCCGACCTGAAGCTGGGCTCCTCCGTCACCTACTACTGCCAC       GGGGGCTACGAAGTTGAGGGCACCTCGACCCTGAGCTGCATCCTGGGGCCTGATGGGAAGCCCGTGTG       GAACAATCCCCGGCCAGTCTGCACAGCCCCCTGTGGGGGACAGTATGTGGGTTCGGACGGAGTGGTCT       TGTCCCCCAACTACCCCCAGAACTACACCAGTGGACAGATCTGCTTGTATTTTGTTACTGTGCCCAAG       GACTATGGTGTGGTGTTTGGCCAGTTCGCCTTCTTTCACACGGCCCTCAACGACGTGGTGGAGGTTCA       CGACGGCCACAGCCAGCACTCGCGGCTCCTCAGCTCCCTCTCGGGCTCCCATACAGGTGAATCACTGC       CCTTGGCCACCTCCAATCAAGTTCTCATTAAGTTCAGCGCCAAAGGCCTCGCACCAGCCAGAGGCTTC       CACTTTGTCTACCAAGCGGTTCCTCGAACCAGCGCCACGCAGTGCAGCTCTGTGCCGGAACCCCGCTA       TGGCAAGAGGCTGGGCAGTGACTTCTCGGTGGGGGCCATCGTCCGCTTCGAATGCAACTCCGGCTATG       CCCTGCAGGGGTCGCCAGAGATCGAGTGCCTCCCTGTGCCTGGGGCCTTGGCCCAATGGAATGTCTCA       GCGCCCACGTGTGTGGTGCCGTGTGGAGGCAACCTCACAGAGCGCAGGGGCACCATCCTGTCCCCTGG       CTTCCCAGAGCCGTACCTCAACAGCCTCAACTGTGTGTGGAAGATCGTGGTCCCCGAAGGCGCTGGCA       TCCAGATCCAAGTTGTCAGTTTTGTGACAGAGCAGAACTGGGACTCGCTGGAAGTATTTGATGGTGCA       GATAACACTGTAACCATGCTGGGGAGTTTCTCAGGAACAACCGTGCCTGCCCTTCTGAACAGCACCTC       CAACCAGCTCTACCTTCATTTCTACTCAGATATCAGCGTATCTGCAGCTGGCTTCCACTTGGAGTACA       AAACGGTGGGCCTGAGCAGTTGTCCGGAACCTGCTGTGCCCAGTAACGGGGTGAAGACTGGCGAGCGC       TACTTGGTGAATGATGTGGTGTCTTTCCAGTGTGAGCCGGGATATGCCCTCCAGGGCCACGCCCACAT       CTCCTGCATGCCCGGAACAGTGCGGCGATGGAACTACCCTCCTCCACTCTGTATTGCACAGTGTGGGG       GAACAGTGGAGGAGATGGAGGGGGTGATCCTGAGCCCCGGCTTCCCAGGCAACTACCCCAGTAACATG       GACTGCTCCTGGAAAATAGCACTGCCCGTGGGCTTTGGAGCTCACATCCAGTTCCTGAACTTCTCCAC       CGAGCCCAACCACGACTACATAGAAATCCGGAATGGCCCCTATGAGACCAGCCGCATGATGGGAAGAT       TCAGTGGAAGCGAGCTTCCAAGCTCCCTCCTCTCCACGTCCCACGAGACCACCGTGTATTTCCACAGC       GACCACTCCCAGAATCGGCCAGGATTCAAGCTGGAGTATCAGGCCTATGAACTTCAAGAGTGCCCAGA       CCCAGAGCCCTTTGCCAATGGCATTGTGAGGGGAGCTGGCTACAACGTGGGACAATCAGTGACCTTCG       AGTGCCTCCCGGGGTATCAATTGACTGGCCACCCTGTCCTCACGTGTCAACATGGCACCAACCGGAAC       TGGGACCACCCCCTGCCCAAGTGTGAAGTCCCTTGTGGCGGGAACATCACTTCTTCCAACGGCACTGT       GTACTCCCCGGGGTTCCCTAGCCCGTACTCCAGCTCCCAGGACTGTGTCTGGCTGATCACCGTGCCCA       TTGGCCATGGCGTCCGCCTCAACCTCAGCCTGCTGCAGACAGAGCCCTCTGGAGATTTCATCACCATC       TGGGATGGGCCACAGCAAACAGCACCACGGCTCGGCGTCTTCACCCGGAGCATGGCCAAGAAAACAGT       GCAGAGTTCATCCAACCAGGTCCTGCTCAAGTTCCACCGTGATGCAGCCACAGGGGGGATCTTCGCCA       TAGCTTTCTCCGCTTATCCACTCACCAAATGCCCTCCTCCCACCATCCTCCCCAACGCCGAAGTCGTC       ACAGAGAATGAAGAATTCAATATAGGTGACATCGTACGCTACAGATGCCTCCCTGGCTTTACCTTAGT       GGGGAATGAAATTCTGACCTGCAAACTTGGAACCTACCTGCAGTTTGAAGGACCACCCCCGATATGTG       AAGTGCACTGTCCAACAAATGAGCTTCTGACAGACTCCACAGGCGTGATCCTGAGCCAGAGCTACCCT       GGAAGCTATCCCCAGTTCCAGACCTGCTCTTGGCTGGTGAGAGTGGAGCCCGACTATAACATCTCCCT       CACAGTGGAGTACTTCCTCAGCGAGAAGCAATATGATGAGTTTGAGATTTTTGATGGTCCATCAGGAC       AGAGTCCTCTGCTGAAAGCCCTCAGTGGGAATTACTCAGCTCCCCTGATTGTCACCAGCTCAAGCAAC       TCTGTGTACCTGCGTTGGTCATCTGATCACGCCTACAATCGGAAGGGCTTCAAGATCCGCTATTCAGC       CCCTTACTGCAGCCTGCCCAGGGCTCCACTCCATGGCTTCATCCTAGGCCAGACCAGCACCCAGCCCG       GGGGCTCCATCCACTTTGGCTGCAACGCCGGCTACCGCCTGGTGGGACACAGCATGGCCATCTGTACC       CGGCACCCCCAGGGCTACCACCTGTGGAGCGAAGCCATCCCTCTCTGTCAAGCTCTTTCCTGTGGGCT       TCCTGAGGCCCCCAAGAATGGAATGGTGTTTGGCAAGGAGTACACAGTGGGAACCAAGGCCATGTACA       GCTGCAGTGAAGGCTACCACCTCCAGGCAGGCGCTGAGGCCACTGCAGAGTGTCTGGACACAGGCCTA       TGGAGCAACCGCAATGTCCCACCACAGTGTGTCCCTGTGACTTGTCCTGATGTCAGTAGCATCAGCGT       GGAGCATGGCCGATGGAGGCTTATCTTTGAGACACAGTATCAGTTCCAGGCCCAGCTGATGCTCATCT       GTGACCCTGGCTACTACTATACTGGCCAAAGGGTCATCCGCTGTCAGGCCAATGGCAAATGGAGCCTC       GGGGACTCTACGCCCACCTGCCGAATCATCTCCTGTGGAGAGCTCCCGATTCCCCCCAATGGCCACCG       CATCGGAACACTGTCTGTCTACGGGGCAACAGCCATCTTCTCCTGCAATTCCGGATACACACTGGTGG       GCTCCAGGGTGCGTGAGTGCATGGCCAATGGGCTCTGGAGTGGCTCTGAAGTCCGCTGCCTTGCTGGA       CACTGTGGGACTCCTGAGCCCATTGTCAACGGACACATCAATGGGGAGAACTACAGCTACCGGGGCAG       TGTGGTGTACCAATGCAATGCTGGCTTCCGCCTGATCGGCATGTCTGTGCGCATCTGCCAGCAGGATC       ATCACTGGTCGGGCAAGACCCCTTTCTGTGTGCCAATTACCTGTGGACACCCAGGCAACCCTGTCAAC       GGCCTCACTCAGGGTAACCAGTTTAACCTCAACGATGTGGTCAAGTTTGTTTGCAACCCTGGGTATAT       GGCTGAGGGGGCTGCTAGGTCCCAATGCCTGGCCAGCGGGCAATGGAGTGACATGCTGCCCACCTGCA       GAATCATCAACTGTACAGATCCTGGACACCAAGAAAATAGTGTTCGTCAGGTCCACGCCAGCGGCCCG       CACAGGTTCAGCTTCGGCACCACTGTGTCTTACCGGTGCAACCACGGCTTCTACCTCCTGGGCACCCC       AGTGCTCAGCTGCCAGGGAGATGGCACATGGGACCGTCCCCGCCCCCAGTGTCTCCTGGTGTCCTGTG       GCCATCCGGGCTCCCCGCCTCACTCCCAGATGTCTGGAGACAGTTATACTGTGGGAGCAGTGGTGCGG       TACAGCTGCATCGGCAAGCGTACTCTGGTGGGAAACAGCACCCGCATGTGTGGGCTGGATGGACACTG       GACTGGCTCCCTCCCTCACTGCTCAGGAACCAGCGTGGGAGTTTGCGGTGACCCTGGGATCCCGGCTC       ATGGCATCCGTTTGGGGGACAGCTTTGATCCAGGCACTGTGATGCGCTTCAGCTGTGAAGCTGGCCAC       GTGCTCCGGGGATCGTCAGAGCGCACCTGTCAAGCCAATGGCTCGTGGAGCGGCTCGCAGCCTGAGTG       TGGAGTGATCTCTTGTGGGAACCCTGGGACTCCAAGTAATGCCCGAGTTGTGTTCAGTGATGGCCTGG       TTTTCTCCAGCTCTATCGTCTATGAGTGCCGGGAAGGATACTACGCCACAGGCCTGCTCAGCCGTCAC       TGCTCGGTCAATGGTACCTGGACAGGCAGTGACCCTGAGTGCCTCGTCATAAACTGTGGTGACCCTGG       GATTCCAGCCAATGGCCTTCGGCTGGGCAATGACTTCAGGTACAACAAAACTGTGACATATCAGTGTG       TCCCTGGCTATATGATGGAGTCACATAGAGTATCTGTGCTGAGCTGCACCAAGGACCGGACATGGAAT       GGAACCAAGCCCGTCTGCAAAGCTCTCATGTGCAAGCCACCTCCGCTCATCCCCAATGGGAAGGTGGT       GGGGTCTGACTTCATGTGGGGCTCAAGTGTGACTTATGCCTGCCTGGAGGGGTACCAGCTCTCCCTGC       CCGCGGTGTTCACCTGTGAGGGAAATGGGTCCTGGACCGGAGAGCTGCCTCAGTGTTTCCCTGTGTTC       TGCGGGGATCCTGGTGTCCCGTCCCGTGGGAGGAGAGAGGACCGAGGCTTCTCCTACAGGTCATCTGT       CTCCTTCTCCTGCCATCCCCCTCTGGTGCTGGTGGGCTCTCCACGCAGGTTTTGCCAGTCAGATGGGA       CATGGAGTGGCACCCAGCCCAGCTGCATAGATCCGACCCTGACCACGTGTGCGGACCCTGGTGTGCCA       CAGTTTGGGATACAGAACAATTCTCAGGGCTACCAGGTTGGAAGCACAGTCCTCTTCCGTTGTCAAAA       AGGCTACCTGCTTCAGGGCTCCACCACCAGGACCTGCCTCCCAAACCTGACCTGGAGTGGAACCCCAC       CTGACTGTGTCCCCCACCACTGCAGGCAGCCAGAGACGCCAACGCATGCCAACGTCGGGGCCCTGGAT       TTGCCCTCCATGGGCTACACGCTCATCTACTCCTGCCAGGAGGGCTTCTCCCTCAAGGGTGGCTCCGA       GCACCGCACCTGCAAGGCGGATGGCAGCTGGACAGGCAAGCCGCCCATCTGCCTGGAGGTCCGGCCCA       ATGGGAGACCCATCAACACTGCCCGGGAGCCACCGCTCACCCAAGCCTTGATTCCTGGGGATGTTTTT       GCCAAGAATTCCCTGTGGAAAGGGGCCTATGAATACCAGGGGAAGAAGCAGCCAGCCATGCTCAGAGT       GACTGGCTTCCAAGTTGCCAACAGCAAGGTCAATGCCACCATGATCGACCACAGTGGCGTGGAGCTGC       ACTTGGCTGGAACTTACAAGAAAGAAGATTTTCATCTCCTACTCCAGGTGTACCAGATTACAGGGCCT       GTGGAGATCTTTATGAATAAGTTCAAAGATGATCACTGGGCTTTAGATGGCCATGTCTCGTCAGAGTC       CTCCGGAGCCACCTTCATCTACCAAGGCTCTGTCAAGGGCCAAGGCTTTGGGCAGTTCGGCTTTCAAA       GACTGGACCTCAGGCTGCTGGAGTCAGACCCCGAGTCCATTGGCCGCCACTTTGCTTCCAACAGCAGC       TCAGTGGCAGCCGCGATCCTGGTGCCTTTCATCGCCCTCATTATTGCGGGCTTCGTGCTCTATCTCTA       CAAGCACAGGAGAAGACCCAAAGTTCCTTTCAATGGCTATGCTGGCCACGAGAACACCAATGTTCGGG       CCACATTTGAGAACCCAATGTACGACCGCAACATCCAGCCCACAGACATCATGGCCAGCGAGGCGGAG       TTCACAGTCAGCACAGTGTGCACAGCAGTA TAG   CCACCCGGCCTGGC                                           NOV4a, CG50377-04   SEQ ID NO: 32   3546 aa   MW at 385864.BkD           Protein Sequence                     GQNCTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEEDFDVLSVFDGPPQPE           NLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCGNPGRLPNGIQQGSTFNLG       DKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDACGGTLRGQSGIISSPHFPSEYHNNA       DCTWTILAELGDTIALVFIDFQLEDGYDFLEVTGTEGSSLWFTGASLPAPVISSKNWLRLHFTSDGNH       RQRGFSAQYQVKKQIELKSRGVKLMPSKDNSQKTSVVTQVGVSQGHNMCPDPGIPERGKRLGSDFRLG       SSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRAEMCDAHLRGPSGIITSPNFPIQYDNNAH       CVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYMLTGTSVPDLIVSTNHQMWLLF       QTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGRREGSRFRHGDTLKFECQPAFELVGQKAITCQKNNQ       WSAKKPGCVCSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVI       KDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTSESSNECPDPGVPVNGKR       FGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPG       FYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYL       YLLFSTDKSHSDIGFQLRYEAITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLE       CEPNFQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESG       HDYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEP       EVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLL       SPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGDVLKVYDGNNNSARLLGVFSHSENMGVTLN       STSSSLWLDFITDAENTSKGFELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRG       SEELLCLSGERRTWDRPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHF       LVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSGSTA       TSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLT       GPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVLFPSFNLEPGYDFLHIYDGRDSLSPLIGSFYG       SQLPGRIESSSNSLFLAFRSDASVSNAGFVIDFPENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCH       GGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPK       DYGVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGF       HFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVS       APTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGA       DNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGER       YLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVILSPGFPGNYPSNM       DCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHS       DHSQNRPGFKLEYQAYELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRN       WDHPLPKCEVPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITI       WDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVV       TENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYP       GSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSN       SVYLRWSSDHAYNRKGFKIRYSAPYCSLPEAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICT       RHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGL       WSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSL       GDSTPTCRIISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAG       HCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVN       GLTQGNQFNLNDVVKFVCNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGP       HRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWDRPRPQCLLVSCGHPGSPPHSQMSGDSYTVGAVVR       YSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGH       VLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRH       CSVNGTWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWN       GTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVF       CGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVP       QFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALD       LPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPNGRPINTAREPPLTQALIPGDVF       AKNSLWKGAYEYQGKKQPAMLRVTGFQVANSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGP       VEIFMNKFKDDHWALDGHVSSESSGATFIYQGSVKGQGFGQFGFQRLDLRLLESDPESIGRHFASNSS       SVAAAILVPFIALIIAGFVLYLYKHRRRPKVPFNGYAGHENTNVPATFENPMYDRNIQPTDIMASEAE       FTVSTVCTAV                                     NOV4b, CG50377-01   SEQ ID NO: 33   10136 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 9313                       ATG GCGGGCGCCCCTCCCCCCGCCTTGCTGCTGCCTTGCAGTTTGATCTCAGACTGCTGTGCTAGCAA           TCAGCGACACTCCGTGGGCGTAGGACCCTCCGAGCTAGTCAAGAAGCAAATTGAGTTGAAGTCTCGAG       GTGTGAAGCTGATGCCCAGCAAAGACAACAGCCAGAAGACGTCTGTGTTAACTCAGGTTGGTGTGTCC       CAAGGACATAATATGTGTCCAGACCCTGGCATACCCGAAAGGGGCAAAAGACTAGGCTCGGATTTCAG       GTTAGGATCCAGCGTCCAGTTCACCTGCAACGAGGGCTATGACCTGCAAGGGTCCAAGCGGATCACCT       GTATGAAAGTGAGCGACATGTTTGCGGCCTGGAGCGACCACAGGCCAGTCTGCCGAGCCCGCATGTGT       GATGCCCACCTTCGAGGCCCCTCGGGCATCATCACCTCCCCCAATTTCCCCATTCAGTATGACAACAA       TGCACACTGTGTGTGGATCATCACAGCACTCAACCCCTCCAAGGTGATCAAGCTCGCCTTTGAGGAGT       TTGATTTGGAGAGGGGCTATGACACCCTGACGGTCGGTGATGGTGGTCAGGATGGGGACCAGAAGACA       GTTCTCTACATGTCTCAAAATGCCTGCAGTGACAGCCCTCACACCCCAGGCTCTCGCATCCCAGAGAG       CATGTCTGGGGACATCTGGAGGCAGAAATGGACTGTACTTGAGATCTGTCGTGACATTAGCAGTTCAG       ATGCAAGGTCAGGTTCAGTGAGGAAGTCTCCAAAGACTTCTAATGCTGTGGAACTTGTTGCTCCTGGG       ACAGAGATCGAGCAGGGCAGTTGCGGTGACCCTGGCATACCTGCATATGGCCGGAGGGAAGGCTCCCG       GTTTCACCACGGTGACACACTCAAGTTTGAGTGCCAGCCCGCCTTTGAGCTGGTGGGACAGAAGGCAA       TCACATGCCAAAAGAATAACCAATGGTCGGCTAAGAAGCCAGGCTGCGTGTTCTCCTGCTTCTTCAAC       TTCACCAGCCCGTCTGGGGTTGTCCTGTCTCCCAACTACCCAGAGGACTATGGCAACCACCTCCACTG       TGTCTGGCTCATCCTGGCCAGGCCTGAGAGCCGCATCCACCTGGCCTTCAACGACATTGACGTGGAGC       CTCAGTTTGATTTCCTGGTCATCAAGGATGGGGCCACCGCCGAGGCGCCCGTCCTGGGCACCTTCTCA       GGAAACCAGCTTCCCTCCTCCATCACAAGCAGTGGCCACGTGGCCCGTCTCGAGTTCCAGACTGACCA       CTCCACAGGGAAGAGGGGCTTCAACATCACTTTTACCACCTTCCGACACAACGAGTGCCCGGATCCTG       GCGTTCCAGTAAATGGCAAACGGTTTGGGGACAGCCTCCAGCTGGGCAGCTCCATCTCCTTCCTCTGT       GATGAAGGCTTCCTTGGGACTCAGGGCTCAGAGACCATCACCTGCGTCCTGAAGGAGGGCAGCGTGGT       CTGGAACAGCGCTGTGCTGCGGTGTGAAGCTCCCTGTGGTGGTCACCTGACTTCGCCCAGCGGCACCA       TCCTCTCTCCGGGCTGGCCTGGCTTCTACAAGGATGCCTTGAGCTGTGCCTGGGTGATTGAGGCCCAG       CCAGGCTACCCCATCAAAATCACCTTCGACAGATTCAAAACCGAGGTCAACTATGACACCCTGGAAGT       ACGCGATGGGCGGACTTACTCAGCGCCCTTGATCGGGGTTTACCACGGGACCCAGGTTCCCCAGTTCC       TCATCAGCACCAGCAACTACCTCTACCTCCTCTTCTCTACCGACAAGAGTCACTCGGACATCGGCTTC       CAGCTCCGCTATGAGACTATAACACTGCAGTCAGACCACTGTCTGGATCCAGGAATCCCAGTAAATGG       ACAGCGTCATGGGAATGACTTCTACGTGGGCGCGCTGGTGACCTTCAGCTGTGACTCGGGCTACACAT       TAAGTGACGGGGAGCCTCTGGAGTGTGAGCCCAACTTCCAGTGGAGCCGGGCCCTGCCCAGTTGTGAA       GCTCTCTGTGGTGGCTTCATTCAAGGCTCCAGTGGGACCATCTTGTCGCCAGGGTTCCCTGACTTCTA       CCCCAACAACTTGAACTGCACCTGGATTATCGAAACATCTCATGGCAAGGGTGTGTTCTTCACTTTCC       ACACCTTCCACCTGGAAAGTGGCCATGACTACCTCCTCATCACTGAGAACGGCAGCTTCACCCAGCCC       CTGAGGCAGCTAACTGGATCTCGGCTGCCAGCTCCCATCAGCGCTGGGCTCTATGGCAACTTCACTGC       CCAGGTCCGCTTCATCTCTGATTTCTCCATGTCATATGAAGGATTCAACATCACCTTCTCAGAGTACG       ACTTGGAGCCCTGTGAGGAGCCCGAGGTCCCAGCCTACAGCATCCGGAAGGGCTTGCAGTTTGGCGTG       GGCGACACCTTGACCTTCTCCTGCTTCCCCGGGTACCGTCTGGAGGGCACCGCCCGCATCACGTGCCT       GGGGGGCAGACGGCGCCTGTGGAGCTCGCCTCTGCCAAGGTGTGTTGCTGAGTGTGGGAATTCAGTCA       CAGGCACTCAGGGTACTTTGCTGTCCCCCAACTTTCCTGTGAACTACAATAACAATCATGAATGCATC       TACTCCATCCAGACCCAGCCAGGGAAGGGAATTCAGCTGAAAGCCAGGGCATTCGAACTCTCCGAAGG       AGATGTCCTCAAGGTTTATGATGGCAACAACAACTCCGCCCGTTTGCTGGGAGTTTTTAGCCATTCTG       AGATGATGGGGGTGACTTTGAACAGCACATCCAGCAGTCTGTGGCTTGATTTCATCACTGATGCTGAA       AACACCAGCAAGGGCTTTGAACTGCACTTTTCCAGCTTTGAACTCATCAAATGTGAGGACCCAGGAAC       CCCCAAGTTTGGCTACAAGGTTCATGATGAAGGTCATTTTGCAGGGAGCTCCGTGTCCTTCAGCTGTG       ACCCTGGATACAGCCTGCGGGGTAGTGAGGAGCTGCTGTGTCTGAGTGGAGAGCGCCGGACCTGGGAC       CGGCCTCTGCCCACCTGTGTCGCCGAGTGTGGAGGGACAGTGAGAGGAGAGGTGTCGGGGCAGGTGCT       GTCACCCGGGTATCCAGCTCCCTATGAACACAATCTCAACTGCATCTGGACCATCGAAGCAGAGGCCG       GCTGCACCATTGGGCTACACTTCCTGGTGTTTGACACAGAGGAGGTTCACGACGTGCTGCGCATCTGG       GATGGGCCTGTGGAGAGCGGGGTTCTGCTGAAGGAGCTGAGTGGCCCGGCCCTGCCCAAGGACCTGCA       TAGCACCTTCAACTCGGTCGTCCTGCAGTTCAGCACTGACTTCTTCACCAGCAAGCAGGGCTTTGCCA       TTCAATTTTCAGTGTCCACAGCAACGTCCTGCAATGACCCTGGGATCCCGCAGAATGGGAGTCGGAGT       GGTGACAGTTGGGAAGCCGGCGACTCCACAGTGTTCCAGTGTGACCCTGGCTACGCGCTGCAGGGAAG       TGCAGAGATCAGCTGTGTGAAGATCGAGAACAGGTTCTTCTGGCAGCCCAGCCCGCCAACATGCATCG       CTCCCTGCGGGGGAGACCTGACAGGACCATCTGGAGTCATCCTCTCACCAAATTACCCAGAACCCTAC       CCGCCAGGCAAGGAGTGTGACTGGAAAGTGACCGTCTCACCAGACTACGTCATCGCCCTGGTATTTAA       CATCTTTAACCTGGAGCCTGGCTATGACTTCCTCCATATCTACGACGGACGGGACTCTCTCAGCCCTC       TCATAGGAAGCTTCTATGGCTCCCAGCTCCCAGGCCGCATTGAAAGCAGCAGCAACAGCCTCTTCCTC       GCCTTCCGCAGCGATGCATCTGTGAGCAATGCTGGCTTCGTCATTGACTATACAGAAAACCCGCGGGA       GTCATGTTTTGATCCTGGTTCCATCAAGAACGGCACACGGGTGGGGTCCGACCTGAAGCTGGGCTCCT       CCGTCACCTACTACTGCCACGGGGGCTACGAAGTTGAGGGCACCTCGACCCTGAGCTGCATCCTGGGG       CCTGATGGGAAGCCCGTGTGGAACAATCCCCGGCCAGTCTGCACAGCCCCCTGTGGGGGACAGTATGT       GGGTTCGGACGGAGTGGTCTTGTCCCCCAACTACCCCCAGAACTACACCAGTGGACAGATCTGCTTGT       ATTTTGTTACTGTGCCCAAGGACTATGTGGTGTTTGGCCAGTTCGCCTTCTTTCACACGGCCCTCAAC       GACGTGGTGGAGGTTCACGACGGCCACAGCCAGCACTCGCGGCTCCTCAGCTCCCTCTCGGGCTCCCA       TACAGGAGAATCACTGCCCTTGGCCACCTCCAATCAAGTTCTCATTAAGTTCAGCGCCAAAGGCCTCG       CACCAGCCAGAGGCTTCCACTTTGTCTACCAAGCGGTTCCTCGAACCAGCGCCACGCAGTGCAGCTCT       GTGCCGGAACCCCGCTATGGCAAGAGGCTGGGCAGTGACTTCTCGGTGGGGGCCATCGTCCGCTTCGA       ATGCAACTCCGGCTATGCCCTGCAGGGGTCGCCAGAGATCGAGTGCCTCCCTGTGCCTGGGGCCTTGG       CCCAATGGAATGTCTCAGCGCCCACGTGTGTGGTGCCGTGTGGAGGCAACCTCACAGAGCGCAGGGGC       ACCATCCTGTCCCCTGGCTTCCCAGAGCCGTACCTCAACAGCCTCAACTGTGTGTGGAAGATCGTGGT       CCCCGAAGGCGCTGGCATCCAGATCCAAGTTGTCAGTTTTGTGACAGAGCAGAACTGGGACTCGCTGG       AAGTATTTGATGGTGCAGATAACACTGTAACCATGCTGGGGAGTTTCTCAGGAACAACCGTGCCTGCC       CTTCTGAACAGCACCTCCAACCAGCTCTACCTTCATTTCTACTCAGATATCAGCGTATCTGCAGCTGG       CTTCCACTTGGAGTACAAAACGGTGGGCCTGAGCAGTTGTCCGGAACCTGCTGTGCCCAGTAACGGGG       TGAAGACTGGCGAGCGCTACTTGGTGAATGATGTGGTGTCTTTCCAGTGTGAGCCGGGATATGCCCTC       CAGGGCCACGCCCACATCTCCTGCATGCCCGGAACAGTGCGGCGATGGAACTACCCTCCTCCACTCTG       TATTGCACAGTGTGGGGGAACAGTGGAGGAGATGGAGGGGGTGATCCTGAGCCCCGGCTTCCCAGGCA       ACTACCCCAGTAACATGGACTGCTCCTGGAAAATAGCACTGCCCGTGGGCTTTGGAGCTCACATCCAG       TTCCTGAACTTCTCCACCGAGCCCAACCACGACTACATAGAAATCCGGAATGGCCCCTATGAGACCAG       CCGCATGATGGGAAGATTCAGTGGAAGCGAGCTTCCAAGCTCCCTCCTCTCCACGTCCCACGAGACCA       CCGTGTATTTCCACAGCGACCACTCCCAGAATCGGCCAGGATTCAAGCTGGAGTATCAGGCCTATGAA       CTTCAAGAGTGCCCAGACCCAGAGCCCTTTGCCAATGGCATTGTGAGGGGAGCTGGCTACAACGTGGG       ACAATCAGTGACCTTCGAGTGCCTCCCGGGGTATCAATTGACTGGCCACCCTGTCCTCACGTGTCAAC       ATGGCACCAACCGGAACTGGGACCACCCCCTGCCCAAGTGTGAAGTCCCTTGTGGCGGGAACATCACT       TCTTCCAACGGCACTGTGTACTCCCCGGGGTTCCCTAGCCCGTACTCCAGCTCCCAGGACTGTGTCTG       GCTGATCACCGTGCCCATTGGCCATGGCGTCCGCCTCAACCTCAGCCTGCTGCAGACAGAGCCCTCTG       GAGATTTCATCACCATCTGGGATGGGCCACAGCAAACAGCACCACGGCTCGGCGTCTTCACCCGGAGC       ATGGCCAAGAAAACAGTGCAGAGTTCATCCAACCAGGTCCTGCTCAAGTTCCACCGTGATGCAGCCAC       AGGGGGGATCTTCGCCATAGCTTTCTCCGCTTATCCACTCACCAAATGCCCTCCTCCCACCATCCTCC       CCAACGCCGAAGTCGTCACAGAGAATGAAGAATTCAATATAGGTGACATCGTACGCTACAGATGCCTC       CCTGGCTTTACCTTAGTGGGGAATGAAATTCTGACCTGCAAACTTGGAACCTACCTGCAGTTTGAAGG       ACCACCCCCGATATGTGAAGTGCACTGTCCAACAAATGAGCTTCTGACAGACTCCACAGGCGTGATCC       TGAGCCAGAGCTACCCTGGAAGCTATCCCCAGTTCCAGACCTGCTCTTGGCTGGTGAGAGTGGAGCCC       GACTATAACATCTCCCTCACAGTGGAGTACTTCCTCAGCGAGAAGCAATATGATGAGTTTGAGATTTT       TGATGGTCCATCAGGACAGAGTCCTCTGCTGAAAGCCCTCAGTGGGAATTACTCAGCTCCCCTGATTG       TCACCAGCTCAAGCAACTCTGTGTACCTGCGTTGGTCATCTGATCACGCCTACAATCGGAAGGGCTTC       AAGATCCGCTATTCAGCCCCTTACTGCAGCCTGCCCAGGGCTCCACTCCATGGCTTCATCCTAGGCCA       GACCAGCACCCAGCCCGGGGGCTCCATCCACTTTGGCTGCAACGCCGGCTACCGCCTGGTGGGACACA       GCATGGCCATCTGTACCCGGCACCCCCAGGGCTACCACCTGTGGAGCGAAGCCATCCCTCTCTGTCAA       GCTCTTTCCTGTGGGCTTCCTGAGGCCCCCAAGAATGGAATGGTGTTTGGCAAGGAGTACACAGTGGG       AACCAAGGCCGTGTACAGCTGCAGTGAAGGCTACCACCTCCAGGCAGGCGCTGAGGCCACTGCAGAGT       GTCTGGACACAGGCCTATGGAGCAACCGCAATGTCCCACCACAGTGTGTCCCTGTGACTTGTCCTGAT       GTCAGTAGCATCAGCGTGGAGCATGGCCGATGGAGGCTTATCTTTGAGACACAGTATCAGTTCCAGGC       CCAGCTGATGCTCATCTGTGACCCTGGCTACTACTATACTGGCCAAAGGGTCATCCGCTGTCAGGCCA       ATGGCAAATGGAGCCTCGGGGACTCTACGCCCACCTGCCGAATCATCTCCTGTGGAGAGCTCCCGATT       CCCCCCAATGGCCACCGCATCGGAACACTGTCTGTCTACGGGGCAACAGCCATCTTCTCCTGCAATTC       CGGATACACACTGGTGGGCTCCAGGGTGCGTGAGTGCATGGCCAATGGGCTCTGGAGTGGCTCTGAAG       TCCGCTGCCTTGCTGGACACTGTGGGACTCCTGAGCCCATTGTCAACGGACACATCAATGGGGAGAAC       TACAGCTACCGGGGCAGTGTGGTGTACCAATGCAATGCTGGCTTCCGCCTGATCGGCATGTCTGTGCG       CATCTGCCAGCAGGATCATCACTGGTCGGGCAAGACCCCTTTCTGTGTGCCAATTACCTGTGGACACC       CAGGCAACCCTGTCAACGGCCTCACTCAGGGTAACCAGTTTAACCTCAACGATGTGGTCAAGTTTGTT       TGCAACCCTGGGTATATGGCTGAGGGGGCTGCTAGGTCCCAATGCCTGGCCAGCGGGCAATGGAGTGA       CATGCTGCCCACCTGCAGAATCATCAACTGTACAGATCCTGGACACCAAGAAAATAGTGTTCGTCAGG       TCCACGCCAGCGGCCCGCACAGGTTCAGCTTCGGCACCACTGTGTCTTACCGGTGCAACCACGGCTTC       TACCTCCTGGGCACCCCAGTGCTCAGCTGCCAGGGAGATGGCACATGGGACCGTCCCCGCCCCCAGTG       TCTCTTGGTGTCCTGTGGCCATCCGGGCTCCCCGCCTCACTCCCAGATGTCTGGAGACAGTTATACTG       TGGGAGCAGTGGTGCGGTACAGCTGCATCGGCAAGCGTACTCTGGTGGGAAACAGCACCCGCATGTGT       GGGCTGGATGGACACTGGACTGGCTCCCTCCCTCACTGCTCAGGAACCAGCGTGGGAGTTTGCGGTGA       CCCTGGGATCCCGGCTCATGGCATCCGTTTGGGGGACAGCTTTGATCCAGGCACTGTGATGCGCTTCA       GCTGTGAAGCTGGCCACGTGCTCCGGGGATCGTCAGAGCGCACCTGTCAAGCCAATGGCTCGTGGAGC       GGCTCGCAGCCTGAGTGTGGAGTGATCTCTTGTGGGAACCCTGGGACTCCAAGTAATGCCCGAGTTGT       GTTCAGTGATGGCCTGGTTTTCTCCAGCTCTATCGTCTATGAGTGCCGGGAAGGATACTACGCCACAG       GCCTGCTCAGCCGTCACTGCTCGGTCAATGGTACCTGGACAGGCAGTGACCCTGAGTGCCTCGTCATA       AACTGTGGTGACCCTGGGATTCCAGCCAATGGCCTTCGGCTGGGCAATGACTTCAGGTACAACAAAAC       TGTGACATATCAGTGTGTCCCTGGCTATATGATGGAGTCACATAGAGTATCTGTGCTGAGCTGCACCA       AGGACCGGACATGGAATGGAACCAAGCCCGTCTGCAAAGCTCTCATGTGCAAGCCACCTCCGCTCATC       CCCAATGGGAAGGTGGTGGGGTCTGACTTCATGTGGGGCTCAAGTGTGACTTATGCCTGCCTGGAGGG       GTACCAGCTCTCCCTGCCCGCGGTGTTCACCTGTGAGGGAAATGGGTCCTGGACCGGAGAGCTGCCTC       AGTGTTTCCCTGTGTTCTGCGGGGATCCTGGTGTCCCGTCCCGTGGGAGGAGAGAGGACCGAGGCTTC       TCCTACAGGTCATCTGTCTCCTTCTCCTGCCATCCCCCTCTGGTGCTGGTGGGCTCTCCACGCAGGTT       TTGCCAGTCAGATGGGACATGGAGTGGCACCCAGCCCAGCTGCATAGATCCGACCCTGACCACGTGTG       CGGACCCTGGTGTGCCACAGTTTGGGATACAGAACAATTCTCAGGGCTACCAGGTTGGAAGCACAGTC       CTCTTCCGTTGTCAAAAAGGCTACCTGCTTCAGGGCTCCACCACCAGGACCTGCCTCCCAAACCTGAC       CTGGAGTGGAACCCCACCTGACTGTGTCCCCCACCACTGCAGGCAGCCAGAGACGCCAACGCATGCCA       ACGTCGGGGCCCTGGATTTGCCCTCCATGGGCTACACGCTCATTACTCCTGCCAGGAGGGCTTCTCCC       TCAAGGGTGGCTCCGAGCACCGCACCTGCAAGGCGGATGGCAGCTGGACAGGCAAGCCGCCCATCTGC       CTGGAGGTCCGGCCCAGTGGGAGACCCATCAACACTGCCCGGGAGCCACCGCTCACCCAAGCCT TGA   T           TCCTGGGGATGTTTTTGCCAAGAATTCCCTGTGGAAAGGGGCCTATGAATACCAGGGGAAGAAGCAGC           CAGCCATGCTCAGAGTGACTGGCTTCCAAGTTGCCAACAGCAAGGTCAATGCCACCATGATCGACCAC           AGTGGCGTGGAGCTGCACTTGGCTGGAACTTACAAGAAAGAAGATTTTCATCTCCTACTCCAGGTGTA           CCAGATTACAGGGCCTGTGGAGATCTTTATGAATAAGTTCAAAGATGATCACTGGGCTTTAGATGGCC           ATGTCTCGTCAGAGTCCTCCGGAGCCACCTTCATCTACCAAGGCTCTGTCAAGGGCCAAGGCTTTGGG           CAGTTCGGCTTTCAAAGACTGGACCTCAGGCTGCTGGAGTCAGACCCCGAGTCCATTGGCCGCCACTT           TGCTTCCAACAGCAGCTCAGTGGCAGCCGCGATCCTGGTGCCTTTCATCGCCCTCATTATTGCGGGCT           TCGTGCTCTATCTCTACAAGCACAGGAGAAGACCCAAAGTTCCTTTCAATGGCTATGCTGGCCACGAG           AACACCAATGTTCGGGCCACATTTGAGAACCCAATGTACGACCGCAACATCCAGCCCACAGACATCAT           GGCCAGCGAGGCGGAGTTCACAGTCAGCACAGTGTGCACAGCAGTATAGCCACCCGGCCTGGCCGCTT           TTTTTGCTAGGTTGAACTGGTACTCCAGCAGCCGCCGAAGCTGGACTGTACTGCTGCCATCTCAGCTC           ACTGCAACCTCCCTGCCTGATTCCCCTGCCTCAGCCTGCCGAGTGCCTGCGATTGCAGGCGCGCACCG           CCAC                                           Nov4b, CG50377-01   SEQ ID NO: 34   3104 aa   MW at 336746.3kD           Protein Sequence                     MAGAPPPALLLPCSLISDCCASNQRHSVGVGPSELVKKQIELKSRGVKLMPSKDNSQKTSVLTQVGVS           QGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMC       DAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKT       VLYMSQNACSDSPHTPGSRIPESMSGDIWRQKWTVLEICRDISSSDARSGSVRKSPKTSNAVELVAPG       TEIEQGSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFN       FTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFS       GNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLC       DEGFLGTQGSETITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQ       PGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGF       QLRYETITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCE       ALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITENGSFTQP       LRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQFGV       GDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECI       YSIQTQPGKGIQLKAPAFELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAE       NTSKGFELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWD       RPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIW       DGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNCSRS       GDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGPSGVILSPNYPEPY       PPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFL       AFRSDASVSNAGFVIDYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILG       PDGKPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALN       DVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSS       VPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRG       TILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPA       LLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYAL       QGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEENEGVILSPGFPGNYPSNNDCSWKIALPVGFGAHIQ       FLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQAYE       LQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNIT       SSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRS       MAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCL       PGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEP       DYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGF       KIRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQ       ALSCGLPEAPKNGMVFGKEYTVGTKAVYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPD       VSSISVEHGRWPLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPI       PPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGEN       YSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFV       CNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGF       YLLGTPVLSCQGDGTWDRPRPQCLLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMC       GLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGBVLRGSSERTCQANGSWS       GSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVI       NCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLI       PNGKVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGF       SYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTV       LFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGYTLITPARRASP       SRVAPSTAPARRMAAGQASRPSAWRSGPVGDPSTLPGSHRSPKP                                     NOV4c, CG50377-02   SEQ ID NO: 35   8010 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAG at 8008                       ATG GCGGGCGCCCCTCCCCCCGCCTTGCTGCTGCCTTGCAGTTTGATCTCAGACTGCTGTGCTAGCAA           TCAGCGACACTCCGTGGGCGTAGGACCCTCCGAGCTAGTCAAGAAGCAAATTGAGTTGAAGTCTCGAG       GTGTGAAGCTGATGCCCAGCAAAGACAACAGCCAGAAGACGTCTGTGTTAACTCAGGTTGGTGTGTCC       CAAGGACATAATATGTGTCCAGACCCTGGCATACCCGAAAGGGGCAAAAGACTAGGCTCGGATTTCAG       GTTAGGATCCAGCGTCCAGTTCACCTGCAACGAGGGCTATGACCTGCAAGGGTCCAAGCGGATCACCT       GTATGAAAGTGAGCGACATGTTTGCGGCCTGGAGCGACCACAGGCCAGTCTGCCGAGCCCGCATGTGT       GATGCCCACCTTCGAGGCCCCTCGGGCATCATCACCTCCCCCAATTTCCCCATTCAGTATGACAACAA       TGCACACTGTGTGTGGATCATCACAGCACTCAACCCCTCCAAGGTGATCAAGCTCGCCTTTGAGGAGT       TTGATTTGGAGAGGGGCTATGACACCCTGACGGTCGGTGATGGTGGTCAGGATGGGGACCAGAAGACA       GTTCTCTACATGTCTCAAAATGCCTGCAGTGACAGCCCTCACACCCCAGGCTCTCGCATCCCAGAGAG       CATGTCTGGGGACATCTGGAGGCAGAAATGGACTGTACTTGAGATCTGTCGTGACATTAGCAGTTCAG       ATGCAAGGTCAGGTTCAGTGAGGAAGTCTCCAAAGACTTCTAATGCTGTGGAACTTGTTGCTCCTGGG       ACAGAGATCGAGCAGGGCAGTTGCGGTGACCCTGGCATACCTGCATATGGCCGGAGGGAAGGCTCCCG       GTTTCACCACGGTGACACACTCAAGTTTGAGTGCCAGCCCGCCTTTGAGCTGGTGGGACAGAAGGCAA       TCACATGCCAAAAGAATAACCAATGGTCGGCTAAGAAGCCAGGCTGCGTGTTCTCCTGCTTCTTCAAC       TTCACCAGCCCGTCTGGGGTTGTCCTGTCTCCCAACTACCCAGAGGACTATGGCAACCACCTCCACTG       TGTCTGGCTCATCCTGGCCAGGCCTGAGAGCCGCATCCACCTGGCCTTCAACGACATTGACGTGGAGC       CTCAGTTTGATTTCCTGGTCATCAAGGATGGGGCCACCGCCGAGGCGCCCGTCCTGGGCACCTTCTCA       GGAAACCAGCTTCCCTCCTCCATCACAAGCAGTGGCCACGTGGCCCGTCTCGAGTTCCAGACTGACCA       CTCCACAGGGAAGAGGGGCTTCAACATCACTTTTACCACCTTCCGACACAACGAGTGCCCGGATCCTG       GCGTTCCAGTAAATGGCAAACGGTTTGGGGACAGCCTCCAGCTGGGCAGCTCCATCTCCTTCCTCTGT       GATGAAGGCTTCCTTGGGACTCAGGGCTCAGAGACCATCACCTGCGTCCTGAAGGAGGGCAGCGTGGT       CTGGAACAGCGCTGTGCTGCGGTGTGAAGCTCCCTGTGGTGGTCACCTGACTTCGCCCAGCGGCACCA       TCCTCTCTCCGGGCTGGCCTGGCTTCTACAAGGATGCCTTGAGCTGTGCCTGGGTGATTGAGGCCCAG       CCAGGCTACCCCATCAAAATCACCTTCGACAGATTCAAAACCGAGGTCAACTATGACACCCTGGAAGT       ACGCGATGGGCGGACTTACTCAGCGCCCTTGATCGGGGTTTACCACGGGACCCAGGTTCCCCAGTTCC       TCATCAGCACCAGCAACTACCTCTACCTCCTCTTCTCTACCGACAAGAGTCACTCGGACATCGGCTTC       CAGCTCCGCTATGAGACTATAACACTGCAGTCAGACCACTGTCTGGATCCAGGAATCCCAGTAAATGG       ACAGCGTCATGGGAATGACTTCTACGTGGGCGCGCTGGTGACCTTCAGCTGTGACTCGGGCTACACAT       TAAGTGACGGGGAGCCTCTGGAGTGTGAGCCCAACTTCCAGTGGAGCCGGGCCCTGCCCAGTTGTGAA       GCTCTCTGTGGTGGCTTCATTCAAGGCTCCAGTGGGACCATCTTGTCGCCAGGGTTCCCTGACTTCTA       CCCCAACAACTTGAACTGCACCTGGATTATCGAAACATCTCATGGCAAGGGTGTGTTCTTCACTTTCC       ACACCTTCCACCTGGAAAGTGGCCATGACTACCTCCTCATCACTGAGAACGGCAGCTTCACCCAGCCC       CTGAGGCAGCTAACTGGATCTCGGCTGCCAGCTCCCATCAGCGCTGGGCTCTATGGCAACTTCACTGC       CCAGGTCCGCTTCATCTCTGATTTCTCCATGTCATATGAAGGATTCAACATCACCTTCTCAGAGTACG       ACTTGGAGCCCTGTGAGGAGCCCGAGGTCCCAGCCTACAGCATCCGGAAGGGCTTGCAGTTTGGCGTG       GGCGACACCTTGACCTTCTCCTGCTTCCCCGGGTACCGTCTGGAGGGCACCGCCCGCATCACGTGCCT       GGGGGGCAGACGGCGCCTGTGGAGCTCGCCTCTGCCAAGGTGTGTTGCTGAGTGTGGGAATTCAGTCA       CAGGCACTCAGGGTACTTTGCTGTCCCCCAACTTTCCTGTGAACTACAATAACAATCATGAATGCATC       TACTCCATCCAGACCCAGCCAGGGAAGGGAATTCAGCTGAAAGCCAGGGCATTCGAACTCTCCGAAGG       AGATGTCCTCAAGGTTTATGATGGCAACAACAACTCCGCCCGTTTGCTGGGAGTTTTTAGCCATTCTG       AGATGATGGGGGTGACTTTGAACAGCACATCCAGCAGTCTGTGGCTTGATTTCATCACTGATGCTGAA       AACACCAGCAAGGGCTTTGAACTGCACTTTTCCAGCTTTGAACTCATCAAATGTGAGGACCCAGGAAC       CCCCAAGTTTGGCTACAAGGTTCATGATGAAGGTCATTTTGCAGGGAGCTCCGTGTCCTTCAGCTGTG       ACCCTGGATACAGCCTGCGGGGTAGTGAGGAGCTGCTGTGTCTGAGTGGAGAGCGCCGGACCTGGGAC       CGGCCTCTGCCCACCTGTGTCGCCGAGTGTGGAGGGACAGTGAGAGGAGAGGTGTCGGGGCAGGTGCT       GTCACCCGGGTATCCAGCTCCCTATGAACACAATCTCAACTGCATCTGGACCATCGAAGCAGAGGCCG       GCTGCACCATTGGGCTACACTTCCTGGTGTTTGACACAGAGGAGGTTCACGACGTGCTGCGCATCTGG       GATGGGCCTGTGGAGAGCGGGGTTCTGCTGAAGGAGCTGAGTGGCCCGGCCCTGCCCAAGGACCTGCA       TAGCACCTTCAACTCGGTCGTCCTGCAGTTCAGCACTGACTTCTTCACCAGCAAGCAGGGCTTTGCCA       TTCAATTTTCAGTGTCCACAGCAACGTCCTGCAATGACCCTGGGATCCCGCAGAATGGGAGTCGGAGT       GGTGACAGTTGGGAAGCCGGCGACTCCACAGTGTTCCAGTGTGACCCTGGCTACGCGCTGCAGGGAAG       TGCAGAGATCAGCTGTGTGAAGATCGAGAACAGGTTCTTCTGGCAGCCCAGCCCGCCAACATGCATCG       CTCCCTGCGGGGGAGACCTGACAGGACCATCTGGAGTCATCCTCTCACCAAATTACCCAGAACCCTAC       CCGCCAGGCAAGGAGTGTGACTGGAAAGTGACCGTCTCACCAGACTACGTCATCGCCCTGGTATTTAA       CATCTTTAACCTGGAGCCTGGCTATGACTTCCTCCATATCTACGACGGACGGGACTCTCTCAGCCCTC       TCATAGGAAGCTTCTATGGCTCCCAGCTCCCAGGCCGCATTGAAAGCAGCAGCAACAGCCTCTTCCTC       GCCTTCCGCAGCGATGCATCTGTGAGCAATGCTGGCTTCGTCATTGACTATACAGAAAACCCGCGGGA       GTCATGTTTTGATCCTGGTTCCATCAAGAACGGCACACGGGTGGGGTCCGACCTGAAGCTGGGCTCCT       CCGTCACCTACTACTGCCACGGGGGCTACGAAGTTGAGGGCACCTCGACCCTGAGCTGCATCCTGGGG       CCTGATGGGAAGCCCGTGTGGAACAATCCCCGGCCAGTCTGCACAGCCCCCTGTGGGGGACAGTATGT       GGGTTCGGACGGAGTGGTCTTGTCCCCCAACTACCCCCAGAACTACACCAGTGGACAGATCTGCTTGT       ATTTTGTTACTGTGCCCAAGGACTATGTGGTGTTTGGCCAGTTCGCCTTCTTTCACACGGCCCTCAAC       GACGTGGTGGAGGTTCACGACGGCCACAGCCAGCACTCGCGGCTCCTCAGCTCCCTCTCGGGCTCCCA       TACAGGAGAATCACTGCCCTTGGCCACCTCCAATCAAGTTCTCATTAAGTTCAGCGCCAAAGGCCTCG       CACCAGCCAGAGGCTTCCACTTTGTCTACCAAGCGGTTCCTCGAACCAGCGCCACGCAGTGCAGCTCT       GTGCCGGAACCCCGCTATGGCAAGAGGCTGGGCAGTGACTTCTCGGTGGGGGCCATCGTCCGCTTCGA       ATGCAACTCCGGCTATGCCCTGCAGGGGTCGCCAGAGATCGAGTGCCTCCCTGTGCCTGGGGCCTTGG       CCCAATGGAATGTCTCAGCGCCCACGTGTGTGGTGCCGTGTGGAGGCAACCTCACAGAGCGCAGGGGC       ACCATCCTGTCCCCTGGCTTCCCAGAGCCGTACCTCAACAGCCTCAACTGTGTGTGGAAGATCGTGGT       CCCCGAAGGCGCTGGCATCCAGATCCAAGTTGTCAGTTTTGTGACAGAGCAGAACTGGGACTCGCTGG       AAGTATTTGATGGTGCAGATAACACTGTAACCATGCTGGGGAGTTTCTCAGGAACAACCGTGCCTGCC       CTTCTGAACAGCACCTCCAACCAGCTCTACCTTCATTTCTACTCAGATATCAGCGTATCTGCAGCTGG       CTTCCACTTGGAGTACAAAACGGTGGGCCTGAGCAGTTGTCCGGAACCTGCTGTGCCCAGTAACGGGG       TGAAGACTGGCGAGCGCTACTTGGTGAATGATGTGGTGTCTTTCCAGTGTGAGCCGGGATATGCCCTC       CAGGGCCACGCCCACATCTCCTGCATGCCCGGAACAGTGCGGCGATGGAACTACCCTCCTCCACTCTG       TATTGCACAGTGTGGGGGAACAGTGGAGGAGATGGAGGGGGTGATCCTGAGCCCCGGCTTCCCAGGCA       ACTACCCCAGTAACATGGACTGCTCCTGGAAAATAGCACTGCCCGTGGGCTTTGGAGCTCACATCCAG       TTCCTGAACTTCTCCACCGAGCCCAACCACGACTACATAGAAATCCGGAATGGCCCCTATGAGACCAG       CCGCATGATGGGAAGATTCAGTGGAAGCGAGCTTCCAAGCTCCCTCCTCTCCACGTCCCACGAGACCA       CCGTGTATTTCCACAGCGACCACTCCCAGAATCGGCCAGGATTCAAGCTGGAGTATCAGGCCTATGAA       CTTCAAGAGTGCCCAGACCCAGAGCCCTTTGCCAATGGCATTGTGAGGGGAGCTGGCTACAACGTGGG       ACAATCAGTGACCTTCGAGTGCCTCCCGGGGTATCAATTGACTGGCCACCCTGTCCTCACGTGTCAAC       ATGGCACCAACCGGAACTGGGACCACCCCCTGCCCAAGTGTGAAGTCCCTTGTGGCGGGAACATCACT       TCTTCCAACGGCACTGTGTACTCCCCGGGGTTCCCTAGCCCGTACTCCAGCTCCCAGGACTGTGTCTG       GCTGATCACCGTGCCCATTGGCCATGGCGTCCGCCTCAACCTCAGCCTGCTGCAGACAGAGCCCTCTG       GAGATTTCATCACCATCTGGGATGGGCCACAGCAAACAGCACCACGGCTCGGCGTCTTCACCCGGAGC       ATGGCCAAGAAAACAGTGCAGAGTTCATCCAACCAGGTCCTGCTCAAGTTCCACCGTGATGCAGCCAC       AGGGGGGATCTTCGCCATAGCTTTCTCCGCTTATCCACTCACCAAATGCCCTCCTCCCACCATCCTCC       CCAACGCCGAAGTCGTCACAGAGAATGAAGAATTCAATATAGGTGACATCGTACGCTACAGATGCCTC       CCTGGCTTTACCTTAGTGGGGAATGAAATTCTGACCTGCAAACTTGGAACCTACCTGCAGTTTGAAGG       ACCACCCCCGATATGTGAAGTGCACTGTCCAACAAATGAGCTTCTGACAGACTCCACAGGCGTGATCC       TGAGCCAGAGCTACCCTGGAAGCTATCCCCAGTTCCAGACCTGCTCTTGGCTGGTGAGAGTGGAGCCC       GACTATAACATCTCCCTCACAGTGGAGTACTTCCTCAGCGAGAAGCAATATGATGAGTTTGAGATTTT       TGATGGTCCATCAGGACAGAGTCCTCTGCTGAAAGCCCTCAGTGGGAATTACTCAGCTCCCCTGATTG       TCACCAGCTCAAGCAACTCTGTGTACCTGCGTTGGTCATCTGATCACGCCTACAATCGGAAGGGCTTC       AAGATCCGCTATTCAGCCCCTTACTGCAGCCTGCCCAGGGCTCCACTCCATGGCTTCATCCTAGGCCA       GACCAGCACCCAGCCCGGGGGCTCCATCCACTTTGGCTGCAACGCCGGCTACCGCCTGGTGGGACACA       GCATGGCCATCTGTACCCGGCACCCCCAGGGCTACCACCTGTGGAGCGAAGCCATCCCTCTCTGTCAA       GCTCTTTCCTGTGGGCTTCCTGAGGCCCCCAAGAATGGAATGGTGTTTGGCAAGGAGTACACAGTGGG       AACCAAGGCCATGTACAGCTGCAGTGAAGGCTACCACCTCCAGGCAGGCGCTGAGGCCACTGCAGAGT       GTCTGGACACAGGCCTATGGAGCAACCGCAATGTCCCACCACAGTGTGTCCGTGAGTCCTCGGGCAAT       GGAGGCGGGTCTGTGACTTGTCCTGATGTCAGTAGCATCAGCGTGGAGCATGGCCGATGGAGGCTTAT       CTTTGAGACACAGTATCAGTTCCAGGCCCAGCTGATGCTCATCTGTGACCCTGGCTACTACTATACTG       GCCAAAGGGTCATCCGCTGTCAGGCCAATGGCAAATGGAGCCTCGGGGACTCTACGCCCACCTGCCGA       ATCATCTCCTGTGGAGAGCTCCCGATTCCCCCCAATGGCCACCGCATCGGAACACTGTCTGTCTACGG       GGCAACAGCCATCTTCTCCTGCAATTCCGGATACACACTGGTGGGCTCCAGGGTGCGTGAGTGCATGG       CCAATGGGCTCTGGAGTGGCTCTGAAGTCCGCTGCCTTGCCACTCAGACCAAGCTCCACTCCATTTTC       TATAAGCTCCTCTTCGATGTACTCTCTTCCCCATCCCTCACCAAAGCTGGACACTGTGGGACTCCTGA       GCCCATTGTCAACGGACACATCAATGGGGAGAACTACAGCTACCGGGGCAGTGTGGTGTACCAATGCA       ATGCTGGCTTCCGCCTGATCGGCATGTCTGTGCGCATCTGCCAGCAGGATCATCACTGGTCGGGCAAG       ACCCCTTTCTGTGTGCATGTTAAGCAGCAGTTGCTGCTGCTGCTGCTGCTGTTGTGTGATGATGATGA       TGATGAAGATGATGGTAGTGGTGCAATTACCTGTGGACACCCAGGCAACCCTGTCAACGGCCTCACTC       AGGGTAACCAGTTTAACCTCAACGATGTGGTCAAGTTTGTTTGCAACCCTGGGTATATGGCTGAGGGG       GCTGCTAGGTCCCAATGCCTGGCCAGCGGGCAATGGAGTGACATGCTGCCCACCTGCAGAATCATCAA       CTGTACAGATCCTGGACACCAAGAAAATAGTGTTCGTCAGGTCCACGCCAGCGGCCCGCACAGGTTCA       GCTTCGGCACCACTGTGTCTTACCGGTGCAACCACGGCTTCTACCTCCTGGGCACCCCAGTGCTCAGC       TGCCAGGGAGATGGCACATGGGACCGTCCCCGCCCCCAGTGTCTCTGTAAG TAG                                           NOV4c, CG50377-02   SEQ ID NO: 36   2669 aa   MW at 290805.9kD           Protein Sequence                     MAGAPPPALLLPCSLISDCCASNQRHSVGVGPSELVKKQIELKSRGVKLMPSKDNSQKTSVLTQVGVS           QGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCPARMC       DAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKT       VLYMSQNACSDSPHTPGSRIPESMSGDIWRQKWTVLEICRDISSSDARSGSVRKSPKTSNAVELVAPG       TEIEQGSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFN       FTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFS       GNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLC       DEGFLGTQGSETITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQ       PGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGF       QLRYETITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSPALPSCE       ALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITENGSFTQP       LRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQFGV       GDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECI       YSIQTQPGKGIQLKAPAFELSEGDVLKVYDGNNNSARLLGVFSHSENMGVTLNSTSSSLWLDFITDAE       NTSKGFELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWD       RPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIW       DGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRS       GDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGPSGVILSPNYPEPY       PPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFL       AFRSDASVSNAGFVIDYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILG       PDGKPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALN       DVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSS       VPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGAIAQWNVSAPTCVVPCGGNLTERRG       TILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPA       LLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYAL       QGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQ       FLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQAYE       LQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNIT       SSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRS       MAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCL       PGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEP       DYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGF       KIRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQ       ALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVRESSGN       GGGSVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCR       IISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLATQTKLHSIF       YKLLFDVLSSPSLTKAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGK       TPFCVHVKQQLLLLLLLLCDDDDDEDDGSGAITCGHPGNPVNGLTQGNQFNLNDVVKFVCNPGYMAEG       AARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLS       CQGDGTWDRPRPQCLCK                                     NOV4d, CG50377-03   SEQ ID NO: 37   9951 bp           DNA Sequence   ORF Start: ATG at 1   ORf Stop: TGA at 7837                       ATG GCGGGCGCCCCTCCCCCCGCCTTGCTGCTGCCTTGCAGTTTGATCTCAGACTGCTGTGCTAGCAA           TCAGCGACACTCCGTGGGCGTAGGACCCTCCGAGCTAGTCAAGAAGCAAATTGAGTTGAAGTCTCGAG       GTGTGAAGCTGATGCCCAGCAAAGACAACAGCCAGAAGACGTCTGTGTTAACTCAGGTTGGTGTGTCC       CAAGGACATAATATGTGTCCAGACCCTGGCATACCCGAAAGGGGCAAAAGACTAGGCTCGGATTTCAG       GTTAGGATCCAGCGTCCAGTTCACCTGCAACGAGGGCTATGACCTGCAAGGGTCCAAGCGGATCACCT       GTATGAAAGTGAGCGACATGTTTGCGGCCTGGAGCGACCACAGGCCAGTCTGCCGAGCCCGCATGTGT       GATGCCCACCTTCGAGGCCCCTCGGGCATCATCACCTCCCCCAATTTCCCCATTCAGTATGACAACAA       TGCACACTGTGTGTGGATCATCACAGCACTCAACCCCTCCAAGGTGATCAAGCTCGCCTTTGAGGAGT       TTGATTTGGAGAGGGGCTATGACACCCTGACGGTCGGTGATGGTGGTCAGGATGGGGACCAGAAGACA       GTTCTCTACATGTCTCAAAATGCCTGCAGTGACAGCCCTCACACCCCAGGCTCTCGCATCCCAGAGAG       CATGTCTGGGGACATCTGGAGGCAGAAATGGACTGTACTTGAGATCTGTCGTGACATTAGCAGTTCAG       ATGCAAGGTCAGGTTCAGTGAGGAAGTCTCCAAAGACTTCTAATGCTGTGGAACTTGTTGCTCCTGGG       ACAGAGATCGAGCAGGGCAGTTGCGGTGACCCTGGCATACCTGCATATGGCCGGAGGGAAGGCTCCCG       GTTTCACCACGGTGACACACTCAAGTTTGAGTGCCAGCCCGCCTTTGAGCTGGTGGGACAGAAGGCAA       TCACATGCCAAAAGAATAACCAATGGTCGGCTAAGAAGCCAGGCTGCGTGTTCTCCTGCTTCTTCAAC       TTCACCAGCCCGTCTGGGGTTGTCCTGTCTCCCAACTACCCAGAGGACTATGGCAACCACCTCCACTG       TGTCTGGCTCATCCTGGCCAGGCCTGAGAGCCGCATCCACCTGGCCTTCAACGACATTGACGTGGAGC       CTCAGTTTGATTTCCTGGTCATCAAGGATGGGGCCACCGCCGAGGCGCCCGTCCTGGGCACCTTCTCA       GGAAACCAGCTTCCCTCCTCCATCACAAGCAGTGGCCACGTGGCCCGTCTCGAGTTCCAGACTGACCA       CTCCACAGGGAAGAGGGGCTTCAACATCACTTTTACCACCTTCCGACACAACGAGTGCCCGGATCCTG       GCGTTCCAGTAAATGGCAAACGGTTTGGGGACAGCCTCCAGCTGGGCAGCTCCATCTCCTTCCTCTGT       GATGAAGGCTTCCTTGGGACTCAGGGCTCAGAGACCATCACCTGCGTCCTGAAGGAGGGCAGCGTGGT       CTGGAACAGCGCTGTGCTGCGGTGTGAAGCTCCCTGTGGTGGTCACCTGACTTCGCCCAGCGGCACCA       TCCTCTCTCCGGGCTGGCCTGGCTTCTACAAGGATGCCTTGAGCTGTGCCTGGGTGATTGAGGCCCAG       CCAGGCTACCCCATCAAAATCACCTTCGACAGATTCAAAACCGAGGTCAACTATGACACCCTGGAAGT       ACGCGATGGGCGGACTTACTCAGCGCCCTTGATCGGGGTTTACCACGGGACCCAGGTTCCCCAGTTCC       TCATCAGCACCAGCAACTACCTCTACCTCCTCTTCTCTACCGACAAGAGTCACTCGGACATCGGCTTC       CAGCTCCGCTATGAGACTATAACACTGCAGTCAGACCACTGTCTGGATCCAGGAATCCCAGTAAATGG       ACAGCGTCATGGGAATGACTTCTACGTGGGCGCGCTGGTGACCTTCAGCTGTGACTCGGGCTACACAT       TAAGTGACGGGGAGCCTCTGGAGTGTGAGCCCAACTTCCAGTGGAGCCGGGCCCTGCCCAGTTGTGAA       GCTCTCTGTGGTGGCTTCATTCAAGGCTCCAGTGGGACCATCTTGTCGCCAGGGTTCCCTGACTTCTA       CCCCAACAACTTGAACTGCACCTGGATTATCGAAACATCTCATGGCAAGGGTGTGTTCTTCACTTTCC       ACACCTTCCACCTGGAAAGTGGCCATGACTACCTCCTCATCACTGAGAACGGCAGCTTCACCCAGCCC       CTGAGGCAGCTAACTGGATCTCGGCTGCCAGCTCCCATCAGCGCTGGGCTCTATGGCAACTTCACTGC       CCAGGTCCGCTTCATCTCTGATTTCTCCATGTCATATGAAGGATTCAACATCACCTTCTCAGAGTACG       ACTTGGAGCCCTGTGAGGAGCCCGAGGTCCCAGCCTACAGCATCCGGAAGGGCTTGCAGTTTGGCGTG       GGCGACACCTTGACCTTCTCCTGCTTCCCCGGGTACCGTCTGGAGGGCACCGCCCGCATCACGTGCCT       GGGGGGCAGACGGCGCCTGTGGAGCTCGCCTCTGCCAAGGTGTGTTGCTGAGTGTGGGAATTCAGTCA       CAGGCACTCAGGGTACTTTGCTGTCCCCCAACTTTCCTGTGAACTACAATAACAATCATGAATGCATC       TACTCCATCCAGACCCAGCCAGGGAAGGGAATTCAGCTGAAAGCCAGGGCATTCGAACTCTCCGAAGG       AGATGTCCTCAAGGTTTATGATGGCAACAACAACTCCGCCCGTTTGCTGGGAGTTTTTAGCCATTCTG       AGATGATGGGGGTGACTTTGAACAGCACATCCAGCAGTCTGTGGCTTGATTTCATCACTGATGCTGAA       AACACCAGCAAGGGCTTTGAACTGCACTTTTCCAGCTTTGAACTCATCAAATGTGAGGACCCAGGAAC       CCCCAAGTTTGGCTACAAGGTTCATGATGAAGGTCATTTTGCAGGGAGCTCCGTGTCCTTCAGCTGTG       ACCCTGGATACAGCCTGCGGGGTAGTGAGGAGCTGCTGTGTCTGAGTGGAGAGCGCCGGACCTGGGAC       CGGCCTCTGCCCACCTGTGTCGCCGAGTGTGGAGGGACAGTGAGAGGAGAGGTGTCGGGGCAGGTGCT       GTCACCCGGGTATCCAGCTCCCTATGAACACAATCTCAACTGCATCTGGACCATCGAAGCAGAGGCCG       GCTGCACCATTGGGCTACACTTCCTGGTGTTTGACACAGAGGAGGTTCACGACGTGCTGCGCATCTGG       GATGGGCCTGTGGAGAGCGGGGTTCTGCTGAAGGAGCTGAGTGGCCCGGCCCTGCCCAAGGACCTGCA       TAGCACCTTCAACTCGGTCGTCCTGCAGTTCAGCACTGACTTCTTCACCAGCAAGCAGGGCTTTGCCA       TTCAATTTTCAGTGTCCACAGCAACGTCCTGCAATGACCCTGGGATCCCGCAGAATGGGAGTCGGAGT       GGTGACAGTTGGGAAGCCGGCGACTCCACAGTGTTCCAGTGTGACCCTGGCTACGCGCTGCAGGGAAG       TGCAGAGATCAGCTGTGTGAAGATCGAGAACAGGTTCTTCTGGCAGCCCAGCCCGCCAACATGCATCG       CTCCCTGCGGGGGAGACCTGACAGGACCATCTGGAGTCATCCTCTCACCAAATTACCCAGAACCCTAC       CCGCCAGGCAAGGAGTGTGACTGGAAAGTGACCGTCTCACCAGACTACGTCATCGCCCTGGTATTTAA       CATCTTTAACCTGGAGCCTGGCTATGACTTCCTCCATATCTACGACGGACGGGACTCTCTCAGCCCTC       TCATAGGAAGCTTCTATGGCTCCCAGCTCCCAGGCCGCATTGAAAGCAGCAGCAACAGCCTCTTCCTC       GCCTTCCGCAGCGATGCATCTGTGAGCAATGCTGGCTTCGTCATTGACTATACAGAAAACCCGCGGGA       GTCATGTTTTGATCCTGGTTCCATCAAGAACGGCACACGGGTGGGGTCCGACCTGAAGCTGGGCTCCT       CCGTCACCTACTACTGCCACGGGGGCTACGAAGTTGAGGGCACCTCGACCCTGAGCTGCATCCTGGGG       CCTGATGGGAAGCCCGTGTGGAACAATCCCCGGCCAGTCTGCACAGCCCCCTGTGGGGGACAGTATGT       GGGTTCGGACGGAGTGGTCTTGTCCCCCAACTACCCCCAGAACTACACCAGTGGACAGATCTGCTTGT       ATTTTGTTACTGTGCCCAAGGACTATGTGGTGTTTGGCCAGTTCGCCTTCTTTCACACGGCCCTCAAC       GACGTGGTGGAGGTTCACGACGGCCACAGCCAGCACTCGCGGCTCCTCAGCTCCCTCTCGGGCTCCCA       TACAGGAGAATCACTGCCCTTGGCCACCTCCAATCAAGTTCTCATTAAGTTCAGCGCCAAAGGCCTCG       CACCAGCCAGAGGCTTCCACTTTGTCTACCAAGCGGTTCCTCGAACCAGCGCCACGCAGTGCAGCTCT       GTGCCGGAACCCCGCTATGGCAAGAGGCTGGGCAGTGACTTCTCGGTGGGGGCCATCGTCCGCTTCGA       ATGCAACTCCGGCTATGCCCTGCAGGGGTCGCCAGAGATCGAGTGCCTCCCTGTGCCTGGGGCCTTGG       CCCAATGGAATGTCTCAGCGCCCACGTGTGTGGTGCCGTGTGGAGGCAACCTCACAGAGCGCAGGGGC       ACCATCCTGTCCCCTGGCTTCCCAGAGCCGTACCTCAACAGCCTCAACTGTGTGTGGAAGATCGTGGT       CCCCGAAGGCGCTGGCATCCAGATCCAAGTTGTCAGTTTTGTGACAGAGCAGAACTGGGACTCGCTGG       AAGTATTTGATGGTGCAGATAACACTGTAACCATGCTGGGGAGTTTCTCAGGAACAACCGTGCCTGCC       CTTCTGAACAGCACCTCCAACCAGCTCTACCTTCATTTCTACTCAGATATCAGCGTATCTGCAGCTGG       CTTCCACTTGGAGTACAAAACGGTGGGCCTGAGCAGTTGTCCGGAACCTGCTGTGCCCAGTAACGGGG       TGAAGACTGGCGAGCGCTACTTGGTGAATGATGTGGTGTCTTTCCAGTGTGAGCCGGGATATGCCCTC       CAGGGCCACGCCCACATCTCCTGCATGCCCGGAACAGTGCGGCGATGGAACTACCCTCCTCCACTCTG       TATTGCACAGTGTGGGGGAACAGTGGAGGAGATGGAGGGGGTGATCCTGAGCCCCGGCTTCCCAGGCA       ACTACCCCAGTAACATGGACTGCTCCTGGAAAATAGCACTGCCCGTGGGCTTTGGAGCTCACATCCAG       TTCCTGAACTTCTCCACCGAGCCCAACCACGACTACATAGAAATCCGGAATGGCCCCTATGAGACCAG       CCGCATGATGGGAAGATTCAGTGGAAGCGAGCTTCCAAGCTCCCTCCTCTCCACGTCCCACGAGACCA       CCGTGTATTTCCACAGCGACCACTCCCAGAATCGGCCAGGATTCAAGCTGGAGTATCAGGCCTATGAA       CTTCAAGAGTGCCCAGACCCAGAGCCCTTTGCCAATGGCATTGTGAGGGGAGCTGGCTACAACGTGGG       ACAATCAGTGACCTTCGAGTGCCTCCCGGGGTATCAATTGACTGGCCACCCTGTCCTCACGTGTCAAC       ATGGCACCAACCGGAACTGGGACCACCCCCTGCCCAAGTGTGAAGTCCCTTGTGGCGGGAACATCACT       TCTTCCAACGGCACTGTGTACTCCCCGGGGTTCCCTAGCCCGTACTCCAGCTCCCAGGACTGTGTCTG       GCTGATCACCGTGCCCATTGGCCATGGCGTCCGCCTCAACCTCAGCCTGCTGCAGACAGAGCCCTCTG       GAGATTTCATCACCATCTGGGATGGGCCACAGCAAACAGCACCACGGCTCGGCGTCTTCACCCGGAGC       ATGGCCAAGAAAACAGTGCAGAGTTCATCCAACCAGGTCCTGCTCAAGTTCCACCGTGATGCAGCCAC       AGGGGGGATCTTCGCCATAGCTTTCTCCGCTTATCCACTCACCAAATGCCCTCCTCCCACCATCCTCC       CCAACGCCGAAGTCGTCACAGAGAATGAAGAATTCAATATAGGTGACATCGTACGCTACAGATGCCTC       CCTGGCTTTACCTTAGTGGGGAATGAAATTCTGACCTGCAAACTTGGAACCTACCTGCAGTTTGAAGG       ACCACCCCCGATATGTGAAGTGCACTGTCCAACAAATGAGCTTCTGACAGACTCCACAGGCGTGATCC       TGAGCCAGAGCTACCCTGGAAGCTATCCCCAGTTCCAGACCTGCTCTTGGCTGGTGAGAGTGGAGCCC       GACTATAACATCTCCCTCACAGTGGAGTACTTCCTCAGCGAGAAGCAATATGATGAGTTTGAGATTTT       TGATGGTCCATCAGGACAGAGTCCTCTGCTGAAAGCCCTCAGTGGGAATTACTCAGCTCCCCTGATTG       TCACCAGCTCAAGCAACTCTGTGTACCTGCGTTGGTCATCTGATCACGCCTACAATCGGAAGGGCTTC       AAGATCCGCTATTCAGCTCTTTCCTGTGGGCTTCCTGAGGCCCCCAAGAATGGAATGGTGTTTGGCAA       GGAGTACACAGTGGGAACCAAGGCCATGTACAGCTGCAGTGAAGGCTACCACCTCCAGGCAGGCGCTG       AGGCCACTGCAGAGTGTCTGGACACAGGCCTATGGAGCAACCGCAATGTCCCACCACAGTGTGTCCCT       GTGACTTGTCCTGATGTCAGTAGCATCAGCGTGGAGCATGGCCGATGGAGGCTTATCTTTGAGACACA       GTATCAGTTCCAGGCCCAGCTGATGCTCATCTGTGACCCTGGCTACTACTATACTGGCCAAAGGGTCA       TCCGCTGTCAGGCCAATGGCAAATGGAGCCTCGGGGACTCTACGCCCACCTGCCGAATCATCTCCTGT       GGAGAGCTCCCGATTCCCCCCAATGGCCACCGCATCGGAACACTGTCTGTCTACGGGGCAACAGCCAT       CTTCTCCTGCAATTCCGGATACACACTGGTGGGCTCCAGGGTGCGTGAGTGCATGGCCAATGGGCTCT       GGAGTGGCTCTGAAGTCCGCTGCCTTGCTGGACACTGTGGGACTCCTGAGCCCATTGTCAACGGACAC       ATCAATGGGGAGAACTACAGCTACCGGGGCAGTGTGGTGTACCAATGCAATGCTGGCTTCCGCCTGAT       CGGCATGTCTGTGCGCATCTGCCAGCAGGATCATCACTGGTCGGGCAAGACCCCTTTCTGTCAATTAC       CTGTGGACACCCAGGCAACCCTGTCAACGGCCTCACTCAGGGTAACCAGTTTAACCTCAACGATGTGG       TCAAGTTTGTTTGCAACCCTGGGTATATGGCTGAGGGGGCTGCTAGGTCCCAATGCCTGGCCAGCGGG       CAATGGAGTGACATGCTGCCCACCTGCAGAATCATCAACTGTACAGATCCTGGACACCAAGAAAATAG       TGTTCGTCAGGTCCACGCCAGCGGCCCGCACAGGTTCAGCTTCGGCACCACTGTGTCTTACCGGTGCA       ACCACGGCTTCTACCTCCTGGGCACCCCAGTGCTCAGCTGCCAGGGAGATGGCACATGGGACCGTCCC       CGCCCCCAGTGTCTCTGTAAGTAGTGGTGTCCTGTGGCCATCCGGGCTCCCCGCCTCACTCCCAGATG       TCTGGAGACAGTTATACTGTGGGAGCAGTGGTGCGGTACAGCTGCATCGGCAAGCGTACTCTGGTGGG       AAACAGCACCCGCATGTGTGGGCTGGATGGACACTGGACTGGCTCCCTCCCTCACTGCTCAGGAACCA       GCGTGGGAGTTTGCGG TGA   CCCTGGGATCCCGGCTCATGGCATCCGTTTGGGGGACAGCTTTGATCCA           GGCACTGTGATGCGCTTCAGCTGTGAAGCTGGCCACGTGCTCCGGGGATCGTCAGAGCGCACCTGTCA           AGCCAATGGCTCGTGGAGCGGCTCGCAGCCTGAGTGTGGAGTGATCTCTTGTGGGAACCCTGGGACTC           CAAGTAATGCCCGAGTTGTGTTCAGTGATGGCCTGGTTTTCTCCAGCTCTATCGTCTATGAGTGCCGQ           GAAGGATACTACGCCACAGGCCTGCTCAGCCGTCACTGCTCGGTCAATGGTACCTGGACAGGCAGTGA           CCCTGAGTGCCTCGTCATAAACTGTGGTGACCCTGGGATTCCAGCCAATGGCCTTCGGCTGGGCAATG           ACTTCAGGTACAACAAAACTGTGACATATCAGTGTGTCCCTGGCTATATGATGGAGTCACATAGAGTA           TCTGTGCTGAGCTGCACCAAGGACCGGACATGGAATGGAACCAAGCCCGTCTGCAAAGCTCTCATGTG           CAAGCCACCTCCGCTCATCCCCAATGGGAAGGTGGTGGGGTCTGACTTCATGTGGGGCTCAAGTGTGA           CTTATGCCTGCCTGGAGGGGTACCAGCTCTCCCTGCCCGCGGTGTTCACCTGTGAGGGAAATGGGTCC           TGGACCGGAGAGCTGCCTCAGTGTTTCCCTGTGTTCTGCGGGGATCCTGGTGTCCCGTCCCGTGGGAG           GAGAGAGGACCGAGGCTTCTCCTACAGGTCATCTGTCTCCTTCTCCTGCCATCCCCCTCTGGTGCTGG           TGGGCTCTCCACGCAGGTTTTGCCAGTCAGATGGGACATGGAGTGGCACCCAGCCCAGCTGCATAGAT           CCGACCCTGACCACGTGTGCGGACCCTGGTGTGCCACAGTTTGGGATACAGAACAATTCTCAGGGCTA           CCAGGTTGGAAGCACAGTCCTCTTCCGTTGTCAAAAAGGCTACCTGCTTCAGGGCTCCACCACCAGGA           CCTGCCTCCCAAACCTGACCTGGAGTGGAACCCCACCTGACTGTGTCCCCCACCACTGCAGGCAGCCA           GAGACGCCAACGCATGCCAACGTCGGGGCCCTGGATTTGCCCTCCATGGGCTACACGCTCATTACTCC           TGCCAGGAGGGCTTCTCCCTCAAGGGTGGCTCCGAGCACCGCACCTGCAAGGCGGATGGCAGCTGGAC           AGGCAAGCCGCCCATCTGCCTGGAGGTCCGGCCCAGTGGGAGACCCATCAACACTGCCCGGGAGCCAC           CGCTCACCCAAGCCTTGATTCCTGGGGATGTTTTTGCCAAGAATTCCCTGTGGAAAGGGGCCTATGAA           TACCAGGGGAAGAAGCAGCCAGCCATGCTCAGAGTGACTGGCTTCCAAGTTGCCAACAGCAAGGTCAA           TGCCACCATGATCGACCACAGTGGCGTGGAGCTGCACTTGGCTGGAACTTACAAGAAAGAAGATTTTC           ATCTCCTACTCCAGGTGTACCAGATTACAGGGCCTGTGGAGATCTTTATGAATAAGTTCAAAGATGAT           CACTGGGCTTTAGATGGCCATGTCTCGTCAGAGTCCTCCGGAGCCACCTTCATCTACCAAGGCTCTGT           CAAGGGCCAAGGCTTTGGGCAGTTCGGCTTTCAAAGACTGGACCTCAGGCTGCTGGAGTCAGACCCCG           AGTCCATTGGCCGCCACTTTGCTTCCAACAGCAGCTCAGTGGCAGCCGCGATCCTGGTGCCTTTCATC           GCCCTCATTATTGCGGGCTTCGTGCTCTATCTCTACAAGCACAGGAGAAGACCCAAAGTTCCTTTCAA           TGGCTATGCTGGCCACGAGAACACCAATGTTCGGGCCACATTTGAGAACCCAATGTACGACCGCAACA           TCCAGCCCACAGACATCATGGCCAGCGAGGCGGAGTTCACAGTCAGCACAGTGTGCACAGCAGTATAG           CCACCCGGCCTGGCCGCTTTTTTTGCTAGGTTGAACTGGTACTCCAGCAGCCGCCGAAGCTGGACTGT           ACTGCTGCCATCTCAGCTCACTGCAACCTCCCTGCCTGATTCCCCTGCCTCAGCCTGCCGAGTGCCTG           CGATTGCAGGCGCGCACCGCCAC                                           NOV4d, CG50377-03   SEQ ID NO: 38   2612 aa   MW at 284047.5kD           Protein Sequence                     MAGAPPPALLLPCSLISDCCASNQRHSVGVGPSELVKKQIELKSRGVKLMPSKDNSQKTSVLTQVGVS           QGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMC       DAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKT       VLYMSQNACSDSPHTPGSRIPESMSGDIWRQKWTVLEICRDISSSDARSGSVRKSPKTSNAVELVAPG       TEIEQGSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFN       FTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFS       GNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLC       DEGFLGTQGSETITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQ       PGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGF       QLRYETITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCE       ALCGGFIQGSSGTTLSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITENGSFTQP       LRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQFGV       GDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECI       YSIQTQPGKGIQLKARAFELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAE       NTSKGFELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWD       RPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIW       DGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRS       GDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGPSGVILSPNYPEPY       PPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFL       AFRSDASVSNAGFVIDYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILG       PDGKPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALN       DVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSS       VPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRG       TILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPA       LLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYAL       QGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQ       FLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQAYE       LQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNIT       SSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRS       MAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCL       PGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEP       DYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVVLRWSSDHAYNRKGF       KIRYSALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVP       VTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISC       GELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGH       INGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCQLPVDTQATLSTASLRVTSLTSTMW       SSLFATLGIWLRGLLGPNAWPAGNGVTCCPPAESSTVQILDTKKIVFVRSTPAARTGSASAPLCLTGA       TTASTSWAPQCSAAREMAHGTVPAPSVSVSSGVLWPSGLPASLPDVWRQLYCGSSGAVQLHRQAYSGG       KQHPHVWAGWTLDWLPPSLLPNQRGSLR                                     NOV4e, CG50377-05   SEQ ID NO: 39   10466 bp           DNA Sequence   ORF Start: at 1   ORF Stop: TAG at 10450                     GGCCAGAACTGCACGTTCCAACTGCACGGTCCCAATGGGACAGTTGAGAGCCCAGGGTTCCCATATGG           CTACCCCAATTACGCCAACTGCACGTGGACCATCACCGCGGAAGAGCAGCACAGAATCCAGCTTGTGT       TCCAGTCCTTTGCCCTGGAAGAGGACTTTGATGTCCTGTCGGTGTTTGATGGTCCACCCCAGCCAGAG       AATCTGCGTACGAGGCTCACAGGCTTTCAGCTGCCAGCCACCATTGTTAGTGCAGCCACCACCCTCTC       TCTGCGCCTCATCAGCGACTATGCAGTCAGTGCCCAAGGCTTCCACGCCACCTATGAAGTTCTCCCCA       GCCACACATGTGGGAACCCAGGGAGGCTGCCCAATGGCATCCAGCAGGGTTCAACCTTCAACCTCGGT       GACAAGGTCCGCTACAGCTGCAACCTTGGCTTCTTCCTGGAGGGCCACGCCGTGCTCACCTGCCACGC       TGGCTCTGAGAACAGCGCCACGTGGGACTTCCCCCTGCCTTCCTGCAGAGCTGATGATGCCTGTGGTG       GGACCCTGCGGGGCCAGAGTGGCATCATCTCCAGCCCCCACTTCCCCTCGGAGTACCATAACAATGCC       GACTGCACATGGACCATCCTGGCTGAGCTGGGGGACACCATCGCCCTGGTGTTTATTGACTTCCAGCT       GGAGGATGGTTACGACTTTCTGGAAGTCACTGGGACAGAAGGCTCCTCCCTCTGGTTCACCGGAGCCA       GCCTCCCAGCCCCCGTTATCAGCAGCAAGAACTGGCTGCGACTGCACTTCACATCGGATGGCAACCAC       CGGCAGCGCGGATTCAGTGCCCAATACCAAGTCAAGAAGCAAATTGAGTTGAAGTCTCGAGGTGTGAA       GCTGATGCCCAGCAAAGACAACAGCCAGAAGACGTCTGTGGTAACTCAGGTTGGTGTGTCCCAAGGAC       ATAATATGTGTCCAGACCCTGGCATACCCGAAAGGGGCAAAAGACTAGGCTCGGATTTCAGGTTAGGA       TCCAGCGTCCAGTTCACCTGCAACGAGGGCTATGACCTGCAAGGGTCCAAGCGGATCACCTGTATGAA       AGTGAGCGACATGTTTGCGGCCTGGAGCGACCACAGGCCAGTCTGCCGAGCCCGCATGTGTGATGCCC       ACCTTCGAGGCCCCTCGGGCATCATCACCTCCCCCAATTTCCCCATTCAGTATGACAACAATGCACAC       TGTGTGTGGATCATCACAGCACTCAACCCCTCCAAGGTAATCAAGCTCGCCTTTGAGGAGTTTGATTT       GGAGAGGGGCTATGACACCCTGACGGTCGGTGATGGTGGTCAGGATGGGGACCAGAAGACAGTTCTCT       ACATGCTGACAGGTACATCGGTCCCGGATCTCATTGTCAGCACCAATCATCAAATGTGGCTCCTCTTC       CAGACTGATGGCAGTGGCAGTTCCCTGGGATTCAAGGCTTCTTATGAAGAGATCGAGCAGGGCAGTTG       CGGTGACCCTGGCATACCTGCATATGGCCGGAGGGAAGGCTCCCGGTTTCGCCACGGTGACACACTCA       AGTTTGAGTGCCAGCCCGCCTTTGAGCTGGTGGGACAGAAGGCAATCACATGCCAAAAGAATAACCAA       TGGTCGGCTAAGAAGCCAGGCTGCGTGTGTTCCTGCTTCTTCAACTTCACCAGCCCGTCTGGGGTTGT       CCTGTCTCCCAACTACCCAGAGGACTATGGCAACCACCTCCACTGTGTCTGGCTCATCCTGGCCAGGC       CTGAGAGCCGCATCCACCTGGCCTTCAACGACATTGACGTGGAGCCTCAGTTTGATTTCCTGGTCATC       AAGGATGGGGCCACCGCCGAGGCGCCCGTCCTGGGCACCTTCTCAGGAAACCAGCTTCCCTCCTCCAT       CACAAGCAGTGGCCACGTGGCCCGTCTCGAGTTCCAGACTGACCACTCCACAGGGAAGAGGGGCTTCA       ACATCACTTTTACCAGTGAGTCCTCCAACGAGTGCCCGGATCCTGGCGTTCCAGTAAATGGCAAACGG       TTTGGGGACAGCCTCCAGCTGGGCAGCTCCATCTCCTTCCTCTGTGATGAAGGCTTCCTTGGGACTCA       GGGCTCAGAGACCATCACCTGCGTCCTGAAGGAGGGCAGCGTGGTCTGGAACAGCGCTGTGCTGCGGT       GTGAAGCTCCCTGTGGTGGTCACCTGACTTCGCCCAGCGGCACCATCCTCTCTCCGGGCTGGCCTGGC       TTCTACAAGGATGCCTTGAGCTGTGCCTGGGTGATTGAGGCCCAGCCAGGCTACCCCATCAAAATCAC       CTTCGACAGGTTCAAAACCGAGGTCAACTATGACACCCTGGAAGTACGCGATGGGCGGACTTACTCAG       CGCCCTTGATCGGGGTTTACCACGGGACCCAGGTTCCCCAGTTCCTCATCAGCACCAGCAACTACCTC       TACCTCCTCTTCTCTACCGACAAGAGTCACTCGGACATCGGCTTCCAGCTCCGCTATGAGGCTATAAC       ACTGCAGTCAGACCACTGTCTGGATCCAGGAATCCCAGTAAATGGACAGCGTCATGGGAATGACTTCT       ACGTGGGCGCGCTGGTGACCTTCAGCTGTGACTCGGGCTACACATTAAGTGACGGGGAGCCTCTGGAG       TGTGAGCCCAACTTCCAGTGGAGCCGGGCCCTGCCCAGTTGTGAAGCTCTCTGTGGTGGCTTCATTCA       AGGCTCCAGTGGGACCATCTTGTCGCCAGGTTTCCCTGACTTCTACCCCAACAACTTGAACTGCACCT       GGATTATCGAAACATCTCATGGCAAGGGTGTGTTCTTCACTTTCCACACCTTCCACCTGGAAAGTGGC       CATGACTACCTCCTCATCACTGAGAACGGCAGCTTCACCCAGCCCCTGAGGCAGCTAACTGGATCTCG       GCTGCCAGCTCCCATCAGCGCTGGGCTCTATGGCAACTTCACTGCCCAGGTCCGCTTCATCTCTGATT       TCTCCATGTCATATGAAGGATTCAACATCACCTTCTCAGAGTACGACTTGGAGCCCTGTGAGGAGCCC       GAGGTCCCAGCCTACAGCATCCGGAAGGGCTTGCAGTTTGGCGTGGGCGACACCTTGACCTTCTCCTG       CTTCCCCGGGTACCGTCTGGAGGGCACCGCCCGCATCACGTGCCTGGGGGGCAGACGGCGCCTGTGGA       GCTCGCCTCTGCCAAGGTGTGTTGCTGAGTGTGGGAATTCAGTCACAGGCACTCAGGGTACTTTGCTG       TCCCCCAACTTTCCTGTGAACTACAATAACAATCATGAATGCATCTACTCCATCCAGACCCAGCCAGG       GAAGGGAATTCAGCTGAAAGCCAGGGCATTCGAACTCTCCGAAGGAGATGTCCTCAAGGTTTATGATG       GCAACAACAACTCCGCCCGTTTGCTGGGAGTTTTTAGCCATTCTGAGATGATGGGGGTGACTTTGAAC       AGCACATCCAGCAGTCTGTGGCTTGATTTCATCACTGATGCTGAAAACACCAGCAAGGGCTTTGAACT       GCACTTTTCCAGTTTTGAACTCATCAAATGTGAGGACCCAGGAACCCCCAAGTTTGGCTACAAGGTTC       ATGATGAAGGTCATTTTGCAGGGAGCTCCGTGTCCTTCAGCTGTGACCCTGGATACAGCCTGCGGGGT       AGTGAGGAGCTGCTGTGTCTGAGTGGAGAGCGCCGGACCTGGGACCGGCCTCTGCCCACCTGTGTCGC       CGAGTGTGGAGGGACAGTGAGAGGAGAGGTGTCGGGGCAGGTGCTGTCACCCGGGTATCCAGCTCCCT       ATGAACACAATCTCAACTGCATCTGGACCATCGAAGCAGAGGCCGGCTGCACCATTGGGCTACACTTC       CTGGTGTTTGACACAGAGGAGGTTCACGACGTGCTGCGCATCTGGGATGGGCCTGTGGAGAGCGGGGT       TCTGCTGAAGGAGCTGAGTGGCCCGGCCCTGCCCAAGGACCTGCATAGCACCTTCAACTCGGTCGTCC       TGCAGTTCAGCACTGACTTCTTCACCAGCAAGCAGGGCTTTGCCATTCAATTTTCAGGTTCCACAGCA       ACGTCCTGCAATGACCCTGGGATCCCGCAGAATGGGAGTCGGAGTGGTGACAGTTGGGAAGCCGGCGA       CTCCACAGTGTTCCAGTGTGACCCTGGCTACGCGCTGCAGGGAAGTGCAGAGATCAGCTGTGTGAAGA       TCGAGAACAGGTTCTTCTGGCAGCCCAGCCCGCCAACATGCATCGCTCCCTGCGGGGGAGACCTGACA       GGACCATCTGGAGTCATCCTCTCACCAAATTACCCAGAACCCTACCCGCCAGGCAAGGAGTGTGACTG       GAAAGTGACCGTCTCACCAGACTACGTCATCGCCCTGGTATTGTTCCCCAGCTTTAACCTGGAGCCTG       GCTATGACTTCCTCCATATCTACGACGGACGGGACTCTCTCAGCCCTCTCATAGGAAGCTTCTATGGC       TCCCAGCTCCCAGGCCGCATTGAAAGCAGCAGCAACAGCCTCTTCCTCGCCTTCCGCAGCGATGCATC       TGTGAGCAATGCTGGCTTCGTCATTGACTTCCCAGAAAACCCGCGGGAGTCATGTTTTGATCCTGGTT       CCATCAAGAACGGCACACGGGTGGGGTCCGACCTGAAGCTGGGCTCCTCCGTCACCTACTACTGCCAC       GGGGGCTACGAAGTTGAGGGCACCTCGACCCTGAGCTGCATCCTGGGGCCTGATGGGAAGCCCGTGTG       GAACAATCCCCGGCCAGTCTGCACAGCCCCCTGTGGGGGACAGTATGTGGGTTCGGACGGAGTGGTCT       TGTCCCCCAACTACCCCCAGAACTACACCAGTGGACAGATCTGCTTGTATTTTGTTACTGTGCCCAAG       GACTATGGTGTGGTGTTTGGCCAGTTCGCCTTCTTTCACACGGCCCTCAACGACGTGGTGGAGGTTCA       CGACGGCCACAGCCAGCACTCGCGGCTCCTCAGCTCCCTCTCGGGCTCCCATACAGGTGAATCACTGC       CCTTGGCCACCTCCAATCAAGTTCTCATTAAGTTCAGCGCCAAAGGCCTCGCACCAGCCAGAGGCTTC       CACTTTGTCTACCAAGCGGTTCCTCGAACCAGCGCCACGCAGTGCAGCTCTGTGCCGGAACCCCGCTA       TGGCAAGAGGCTGGGCAGTGACTTCTCGGTGGGGGCCATCGTCCGCTTCGAATGCAACTCCGGCTATG       CCCTGCAGGGGTCGCCAGAGATCGAGTGCCTCCCTGTGCCTGGGGCCTTGGCCCAATGGAATGTCTCA       GCGCCCACGTGTGTGGTGCCGTGTGGAGGCAACCTCACAGAGCGCAGGGGCACCATCCTGTCCCCTGG       CTTCCCAGAGCCGTACCTCAACAGCCTCAACTGTGTGTGGAAGATCGTGGTCCCCGAAGGCGCTGGCA       TCCAGATCCAAGTTGTCAGTTTTGTGACAGAGCAGAACTGGGACTCGCTGGAAGTATTTGATGGTGCA       GATAACACTGTAACCATGCTGGGGAGTTTCTCAGGAACAACCGTGCCTGCCCTTCTGAACAGCACCTC       CAACCAGCTCTACCTTCATTTCTACTCAGATATCAGCGTATCTGCAGCTGGCTTCCACTTGGAGTACA       AAACGGTGGGCCTGAGCAGTTGTCCGGAACCTGCTGTGCCCAGTAACGGGGTGAAGACTGGCGAGCGC       TACTTGGTGAATGATGTGGTGTCTTTCCAGTGTGAGCCGGGATATGCCCTCCAGGGCCACGCCCACAT       CTCCTGCATGCCCGGAACAGTGCGGCGATGGAACTACCCTCCTCCACTCTGTATTGCACAGTGTGGGG       GAACAGTGGAGGAGATGGAGGGGGTGATCCTGAGCCCCGGCTTCCCAGGCAACTACCCCAGTAACATG       GACTGCTCCTGGAAAATAGCACTGCCCGTGGGCTTTGGAGCTCACATCCAGTTCCTGAACTTCTCCAC       CGAGCCCAACCACGACTACATAGAAATCCGGAATGGCCCCTATGAGACCAGCCGCATGATGGGAAGAT       TCAGTGGAAGCGAGCTTCCAAGCTCCCTCCTCTCCACGTCCCACGAGACCACCGTGTATTTCCACAGC       GACCACTCCCAGAATCGGCCAGGATTCAAGCTGGAGTATCAGGCCTATGAACTTCAAGAGTGCCCAGA       CCCAGAGCCCTTTGCCAATGGCATTGTGAGGGGAGCTGGCTACAACGTGGGACAATCAGTGACCTTCG       AGTGCCTCCCGGGGTATCAATTGACTGGCCACCCTGTCCTCACGTGTCAACATGGCACCAACCGGAAC       TGGGACCACCCCCTGCCCAAGTGTGAAGTCCCTTGTGGCGGGAACATCACTTCTTCCAACGGCACTGT       GTACTCCCCGGGGTTCCCTAGCCCGTACTCCAGCTCCCAGGACTGTGTCTGGCTGATCACCGTGCCCA       TTGGCCATGGCGTCCGCCTCAACCTCAGCCTGCTGCAGACAGAGCCCTCTGGAGATTTCATCACCATC       TGGGATGGGCCACAGCAAACAGCACCACGGCTCGGCGTCTTCACCCGGAGCATGGCCAAGAAAACAGT       GCAGAGTTCATCCAACCAGGTCCTGCTCAAGTTCCACCGTGATGCAGCCACAGGGGGGATCTTCGCCA       TAGCTTTCTCCGCTTATCCACTCACCAAATGCCCTCCTCCCACCATCCTCCCCAACGCCGAAGTCGTC       ACAGAGAATGAAGAATTCAATATAGGTGACATCGTACGCTACAGATGCCTCCCTGGCTTTACCTTAGT       GGGGAATGAAATTCTGACCTGCAAACTTGGAACCTACCTGCAGTTTGAAGGACCACCCCCGATATGTG       AAGTGCACTGTCCAACAAATGAGCTTCTGACAGACTCCACAGGCGTGATCCTGAGCCAGAGCTACCCT       GGAAGCTATCCCCAGTTCCAGACCTGCTCTTGGCTGGTGAGAGTGGAGCCCGACTATAACATCTCCCT       CACAGTGGAGTACTTCCTCAGCGAGAAGCAATATGATGAGTTTGAGATTTTTGATGGTCCATCAGGAC       AGAGTCCTCTGCTGAAAGCCCTCAGTGGGAATTACTCAGCTCCCCTGATTGTCACCAGCTCAAGCAAC       TCTGTGTACCTGCGTTGGTCATCTGATCACGCCTACAATCGGAAGGGCTTCAAGATCCGCTATTCAGC       CCTTTCCTGTGGGCTTCCTGAGGCCCCCAAGAATGGAATGGTGTTTGGCAAGGAGTACACAGTGGGAA       CCAAGGCCATGTACAGCTGCAGTGAAGGCTACCACCTCCAGGCAGGCGCTGAGGCCACTGCAGAGTGT       CTGGACACAGGCCTATGGAGCAACCGCAATGTCCCACCACAGTGTGTCCCTGTGACTTGTCCTGATGT       CAGTAGCATCAGCGTGGAGCATGGCCGATGGAGGCTTATCTTTGAGACACAGTATCAGTTCCAGGCCC       AGCTGATGCTCATCTGTGACCCTGGCTACTACTATACTGGCCAAAGGGTCATCCGCTGTCAGGCCAAT       GGCAAATGGAGCCTCGGGGACTCTACGCCCACCTGCCGAATCATCTCCTGTGGAGAGCTCCCGATTCC       CCCCAATGGCCACCGCATCGGAACACTGTCTGTCTACGGGGCAACAGCCATCTTCTCCTGCAATTCCG       GATACACACTGGTGGGCTCCAGGGTGCGTGAGTGCATGGCCAATGGGCTCTGGAGTGGCTCTGAAGTC       CGCTGCCTTGCTGGACACTGTGGGACTCCTGAGCCCATTGTCAACGGACACATCAATGGGGAGAACTA       CAGCTACCGGGGCAGTGTGGTGTACCAATGCAATGCTGGCTTCCGCCTGATCGGCATGTCTGTGCGCA       TCTGCCAGCAGGATCATCACTGGTCGGGCAAGACCCCTTTCTGTGTGCCAATTACCTGTGGACACCCA       GGCAACCCTGTCAACGGCCTCACTCAGGGTAACCAGTTTAACCTCAACGATGTGGTCAAGTTTGTTTG       CAACCCTGGGTATATGGCTGAGGGGGCTGCTAGGTCCCAATGCCTGGCCAGCGGGCAATGGAGTGACA       TGCTGCCCACCTGCAGAATCATCAACTGTACAGATCCTGGACACCAAGAAAATAGTGTTCGTCAGGTC       CACGCCAGCGGCCCGCACAGGTTCAGCTTCGGCACCACTGTGTCTTACCGGTGCAACCACGGCTTCTA       CCTCCTGGGCACCCCAGTGCTCAGCTGCCAGGGAGATGGCACATGGGACCGTCCCCGCCCCCAGTGTC       TCCTGGTGTCCTGTGGCCATCCGGGCTCCCCGCCTCACTCCCAGATGTCTGGAGACAGTTATACTGTG       GGAGCAGTGGTGCGGTACAGCTGCATCGGCAAGCGTACTCTGGTGGGAAACAGCACCCGCATGTGTGG       GCTGGATGGACACTGGACTGGCTCCCTCCCTCACTGCTCAGGAACCAGCGTGGGAGTTTGCGGTGACC       CTGGGATCCCGGCTCATGGCATCCGTTTGGGGGACAGCTTTGATCCAGGCACTGTGATGCGCTTCAGC       TGTGAAGCTGGCCACGTGCTCCGGGGATCGTCAGAGCGCACCTGTCAAGCCAATGGCTCGTGGAGCGG       CTCGCAGCCTGAGTGTGGAGTGATCTCTTGTGGGAACCCTGGGACTCCAAGTAATGCCCGAGTTGTGT       TCAGTGATGGCCTGGTTTTCTCCAGCTCTATCGTCTATGAGTGCCGGGAAGGATACTACGCCACAGGC       CTGCTCAGCCGTCACTGCTCGGTCAATGGTACCTGGACAGGCAGTGACCCTGAGTGCCTCGTCATAAA       CTGTGGTGACCCTGGGATTCCAGCCAATGGCCTTCGGCTGGGCAATGACTTCAGGTACAACAAAACTG       TGACATATCAGTGTGTCCCTGGCTATATGATGGAGTCACATAGAGTATCTGTGCTGAGCTGCACCAAG       GACCGGACATGGAATGGAACCAAGCCCGTCTGCAAAGCTCTCATGTGCAAGCCACCTCCGCTCATCCC       CAATGGGAAGGTGGTGGGGTCTGACTTCATGTGGGGCTCAAGTGTGACTTATGCCTGCCTGGAGGGGT       ACCAGCTCTCCCTGCCCGCGGTGTTCACCTGTGAGGGAAATGGGTCCTGGACCGGAGAGCTGCCTCAG       TGTTTCCCTGTGTTCTGCGGGGATCCTGGTGTCCCGTCCCGTGGGAGGAGAGAGGACCGAGGCTTCTC       CTACAGGTCATCTGTCTCCTTCTCCTGCCATCCCCCTCTGGTGCTGGTGGGCTCTCCACGCAGGTTTT       GCCAGTCAGATGGGACATGGAGTGGCACCCAGCCCAGCTGCATAGATCCGACCCTGACCACGTGTGCG       GACCCTGGTGTGCCACAGTTTGGGATACAGAACAATTCTCAGGGCTACCAGGTTGGAAGCACAGTCCT       CTTCCGTTGTCAAAAAGGCTACCTGCTTCAGGGCTCCACCACCAGGACCTGCCTCCCAAACCTGACCT       GGAGTGGAACCCCACCTGACTGTGTCCCCCACCACTGCAGGCAGCCAGAGACGCCAACGCATGCCAAC       GTCGGGGCCCTGGATTTGCCCTCCATGGGCTACACGCTCATCTACTCCTGCCAGGAGGGCTTCTCCCT       CAAGGGTGGCTCCGAGCACCGCACCTGCAAGGCGGATGGCAGCTGGACAGGCAAGCCGCCCATCTGCC       TGGAGGTCCGGCCCAATGGGAGACCCATCAACACTGCCCGGGAGCCACCGCTCACCCAAGCCTTGATT       CCTGGGGATGTTTTTGCCAAGAATTCCCTGTGGAAAGGGGCCTATGAATACCAGGGGAAGAAGCAGCC       AGCCATGCTCAGAGTGACTGGCTTCCAAGTTGCCAACAGCAAGGTCAATGCCACCATGATCGACCACA       GTGGCGTGGAGCTGCACTTGGCTGGAACTTACAAGAAAGAAGATTTTCATCTCCTACTCCAGGTGTAC       CAGATTACAGGGCCTGTGGAGATCTTTATGAATAAGTTCAAAGATGATCACTGGGCTTTAGATGGCCA       TGTCTCGTCAGAGTCCTCCGGAGCCACCTTCATCTACCAAGGCTCTGTCAAGGGCCAAGGCTTTGGGC       AGTTCGGCTTTCAAAGACTGGACCTCAGGCTGCTGGAGTCAGACCCCGAGTCCATTGGCCGCCACTTT       GCTTCCAACAGCAGCTCAGTGGCAGCCGCGATCCTGGTGCCTTTCATCGCCCTCATTATTGCGGGCTT       CGTGCTCTATCTCTACAAGCACAGGAGAAGACCCAAAGTTCCTTTCAATGGCTATGCTGGCCACGAGA       ACACCAATGTTCGGGCCACATTTGAGAACCCAATGTACGACCGCAACATCCAGCCCACAGACATCATG       GCCAGCGAGGCGGAGTTCACAGTCAGCACAGTGTGCACAGCAGTA TAG   CCACCCGGCCTGGC                                           NOV4e, CG50377-05   SEQ ID NO: 40   3483 aa   MW at 379077.1kD           Protein Sequence                     GQNCTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEEDFDVLSVFDGPPQPE           NLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCGNPGRLPNGIQQGSTFNLG       DKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDACGGTLRGQSGIISSPHFPSEYHNNA       DCTWTILAELGDTIALVFIDFQLEDGYDFLEVTGTEGSSLWFTGASLPAPVISSKNWLRLHFTSDGNH       RQRGFSAQYQVKKQIELKSRGVKLMPSKDNSQKTSWTQVGVSQGHNMCPDPGIPERGKREJGSDFRLG       SSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCEARMCDAHLRGPSGIITSPNFPIQYDNNAH       CVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKTVLYMLTGTSVPDLIVSTNHQMWLLF       QTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGRREGSRFRHGDTLKFECQPAFELVGQKAITCQKNNQ       WSAKKPGCVCSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVI       KDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTSESSNECPDPGVPVNGKR       FGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPG       FYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYL       YLLFSTDKSHSDIGFQLRYEAITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLE       CEPNFQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESG       HDYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEP       EVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLL       SPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLN       STSSSLWLDFITDAENTSKGFELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRG       SEELLCLSGERRTWDRPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHF       LVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSGSTA       TSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLT       GPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVLFPSFNLEPGYDFLHIYDGRDSLSPLIGSFYG       SQLPGRIESSSNSLFLAFRSDASVSNAGFVIDFPENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCH       GGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPK       DYGVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGF       HFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVS       APTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGA       DNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGER       YLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVILSPGFPGNYPSNM       DCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHS       DHSQNRPGFKLEYQAYELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRN       WDHPLPKCEVPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITI       WDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVV       TENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYP       GSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSN       SVYLRWSSDHAYNRKGFKIRYSALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAEC       LDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQAN       GKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEV       RCLAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHP       GNPVNGLTQGNQFNLNDVVKFVCNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQV       HASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWDRPRPQCLLVSCGHPGSPPHSQMSGDSYTV       GAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFS       CEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATG       LLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTK       DRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQ       CFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCA       DPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHAN       VGALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPNGRPINTAREPPLTQALI       PGDVFAKNSLWKGAYEYQGKKQPAMLRVTGFQVANSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVY       QITGPVEIFMNKFKDDHWALDGHVSSESSGATFIYQGSVKGQGFGQFGFQRLDLRLLESDPESIGRHF       ASNSSSVAAAILVPFIALIIAGFVLYLYKHRRRPKVPFNGYAGHENTNVRATFENPMYDRNIQPTDIM       ASEAEFTVSTVCTAV                                     NOV4f, CG50377-06   SEQ ID NO: 41   12901 bp           DNA Sequence   ORF Start: ATG at 889   ORF Stop: TAG at 10279                       GGCCAGAACTGCACGTTCCAACTGCACGGTCCCAATGGGACAGTTGAGAGCCCAGGGTTCCCATATGG               CTACCCCAATTACGCCAACTGCACGTGGACCATCACCGCGGAAGAGCAGCACAGAATCCAGCTTGTGT           TCCAGTCCTTTGCCCTGGAAGAGGACTTTGATGTCCTGTCGGTGTTTGATGGTCCACCCCAGCCAGAG           AATCTGCGTACGAGGCTCACAGGCTTTCAGCTGCCAGCCACCATTGTTAGTGCAGCCACCACCCTCTC           TCTGCGCCTCATCAGCGACTATGCAGTCAGTGCCCAAGGCTTCCACGCCACCTATGAAGTTCTCCCCA           GCCACACATGTGGGAACCCAGGGAGGCTGCCCAATGGCATCCAGCAGGGTTCAACCTTCAACCTCGGT           GACAAGGTCCGCTACAGCTGCAACCTTGGCTTCTTCCTGGAGGGCCACGCCGTGCTCACCTGCCACGC           TGGCTCTGAGAACAGCGCCACGTGGGACTTCCCCCTGCCTTCCTGCAGAGCTGATGATGCCTGTGGTG           GGACCCTGCGGGGCCAGAGTGGCATCATCTCCAGCCCCCACTTCCCCTCGGAGTACCATAACAATGCC           GACTGCACATGGACCATCCTGGCTGAGCTGGGGGACACCATCGCCCTGGTGTTTATTGACTTCCAGCT           GGAGGATGGTTACGACTTTCTGGAAGTCACTGGGACAGAAGGCTCCTCCCTCTGGTTCACCGGAGCCA           GCCTCCCAGCCCCCGTTATCAGCAGCAAGAACTGGCTGCGACTGCACTTCACATCGGATGGCAACCAC           CGGCAGCGCGGATTCAGTGCCCAATACCAAGTCAAGAAGCAAATTGAGTTGAAGTCTCGAGGTGTGAA           GCTG   ATG CCCAGCAAAGACAACAGCCAGAAGACGTCTGTGGTAACTCAGGTTGGTGTGTCCCAAGGAC       ATAATATGTGTCCAGACCCTGGCATACCCGAAAGGGGCAAAAGACTAGGCTCGGATTTCAGGTTAGGA       TCCAGCGTCCAGTTCACCTGCAACGAGGGCTATGACCTGCAAGGGTCCAAGCGGATCACCTGTATGAA       AGTGAGCGACATGTTTGCGGCCTGGAGCGACCACAGGCCAGTCTGCCGAGCCCGCATGTGTGATGCCC       ACCTTCGAGGCCCCTCGGGCATCATCACCTCCCCCAATTTCCCCATTCAGTATGACAACAATGCACAC       TGTGTGTGGATCATCACAGCACTCAACCCCTCCAAGGTAATCAAGCTCGCCTTTGAGGAGTTTGATTT       GGAGAGGGGCTATGACACCCTGACGGTCGGTGATGGTGGTCAGGATGGGGACCAGAAGACAGTTCTCT       ACATGCTGACAGGTACATCGGTCCCGGATCTCATTGTCAGCACCAATCATCAAATGTGGCTCCTCTTC       CAGACTGATGGCAGTGGCAGTTCCCTGGGATTCAAGGCTTCTTATGAAGAGATCGAGCAGGGCAGTTG       CGGTGACCCTGGCATACCTGCATATGGCCGGAGGGAAGGCTCCCGGTTTCGCCACGGTGACACACTCA       AGTTTGAGTGCCAGCCCGCCTTTGAGCTGGTGGGACAGAAGGCAATCACATGCCAAAAGAATAACCAA       TGGTCGGCTAAGAAGCCAGGCTGCGTGTGTTCCTGCTTCTTCAACTTCACCAGCCCGTCTGGGGTTGT       CCTGTCTCCCAACTACCCAGAGGACTATGGCAACCACCTCCACTGTGTCTGGCTCATCCTGGCCAGGC       CTGAGAGCCGCATCCACCTGGCCTTCAACGACATTGACGTGGAGCCTCAGTTTGATTTCCTGGTCATC       AAGGATGGGGCCACCGCCGAGGCGCCCGTCCTGGGCACCTTCTCAGGAAACCAGCTTCCCTCCTCCAT       CACAAGCAGTGGCCACGTGGCCCGTCTCGAGTTCCAGACTGACCACTCCACAGGGAAGAGGGGCTTCA       ACATCACTTTTACCAGTGAGTCCTCCAACGAGTGCCCGGATCCTGGCGTTCCAGTAAATGGCAAACGG       TTTGGGGACAGCCTCCAGCTGGGCAGCTCCATCTCCTTCCTCTGTGATGAAGGCTTCCTTGGGACTCA       GGGCTCAGAGACCATCACCTGCGTCCTGAAGGAGGGCAGCGTGGTCTGGAACAGCGCTGTGCTGCGGT       GTGAAGCTCCCTGTGGTGGTCACCTGACTTCGCCCAGCGGCACCATCCTCTCTCCGGGCTGGCCTGGC       TTCTACAAGGATGCCTTGAGCTGTGCCTGGGTGATTGAGGCCCAGCCAGGCTACCCCATCAAAATCAC       CTTCGACAGGTTCAAAACCGAGGTCAACTATGACACCCTGGAAGTACGCGATGGGCGGACTTACTCAG       CGCCCTTGATCGGGGTTTACCACGGGACCCAGGTTCCCCAGTTCCTCATCAGCACCAGCAACTACCTC       TACCTCCTCTTCTCTACCGACAAGAGTCACTCGGACATCGGCTTCCAGCTCCGCTATGAGGCTATAAC       ACTGCAGTCAGACCACTGTCTGGATCCAGGAATCCCAGTAAATGGACAGCGTCATGGGAATGACTTCT       ACGTGGGCGCGCTGGTGACCTTCAGCTGTGACTCGGGCTACACATTAAGTGACGGGGAGCCTCTGGAG       TGTGAGCCCAACTTCCAGTGGAGCCGGGCCCTGCCCAGTTGTGAAGCTCTCTGTGGTGGCTTCATTCA       AGGCTCCAGTGGGACCATCTTGTCGCCAGGTTTCCCTGACTTCTACCCCAACAACTTGAACTGCACCT       GGATTATCGAAACATCTCATGGCAAGGGTGTGTTCTTCACTTTCCACACCTTCCACCTGGAAAGTGGC       CATGACTACCTCCTCATCACTGAGAACGGCAGCTTCACCCAGCCCCTGAGGCAGCTAACTGGATCTCG       GCTGCCAGCTCCCATCAGCGCTGGGCTCTATGGCAACTTCACTGCCCAGGTCCAATTCATCTCTGATT       TCTCCATGTCATATGAAGGATTCAACATCACCTTCTCAGAGTACGACTTGGAGCCCTGTGAGGAGCCC       GAGGTCCCAGCCTACAGCATCCGGAAGGGCTTGCAGTTTGGCGTGGGCGACACCTTGACCTTCTCCTG       CTTCCCCGGGTACCGTCTGGAGGGCACCGCCCGCATCACGTGCCTGGGGGGCAGACGGCGCCTGTGGA       GCTCGCCTCTGCCAAGGTGTGTTGCTGAGTGTGGGAATTCAGTCACAGGCACTCAGGGTACTTTGCTG       TCCCCCAACTTTCCTGTGAACTACAATAACAATCATGAATGCATCTACTCCATCCAGACCCAGCCAGG       GAAGGGAATTCAGCTGAAAGCCAGGGCATTCGAACTCTCCGAAGGAGATGTCCTCAAGGTTTATGATG       GCAACAACAACTCCGCCCGTTTGCTGGGAGTTTTTAGCCATTCTGAGATGATGGGGGTGACTTTGAAC       AGCACATCCAGCAGTCTGTGGCTTGATTTCATCACTGATGCTGAAAACACCAGCAAGGGCTTTGAACT       GCACTTTTCCAGTTTTGAACTCATCAAATGTGAGGACCCAGGAACCCCCAAGTTTGGCTACAAGGTTC       ATGATGAAGGTCATTTTGCAGGGAGCTCCGTGTCCTTCAGCTGTGACCCTGGATACAGCCTGCGGGGT       AGTGAGGAGCTGCTGTGTCTGAGTGGAGAGCGCCGGACCTGGGACCGGCCTCTGCCCACCTGTGTCGC       CGAGTGTGGAGGGACAGTGAGAGGAGAGGTGTCGGGGCAGGTGCTGTCACCCGGGTATCCAGCTCCCT       ATGAACACAATCTCAACTGCATCTGGACCATCGAAGCAGAGGCCGGCTGCACCATTGGGCTACACTTC       CTGGTGTTTGACACAGAGGAGGTTCACGACGTGCTGCGCATCTGGGATGGGCCTGTGGAGAGCGGGGT       TCTGCTGAAGGAGCTGAGTGGCCCGGCCCTGCCCAAGGACCTGCATAGCACCTTCAACTCGGTCGTCC       TGCAGTTCAGCACTGACTTCTTCACCAGCAAGCAGGGCTTTGCCATTCAATTTTCAGGTTCCACAGCA       ACGTCCTGCAATGACCCTGGGATCCCGCAGAATGGGAGTCGGAGTGGTGACAGTTGGGAAGCCGGCGA       CTCCACAGTGTTCCAGTGTGACCCTGGCTACGCGCTGCAGGGAAGTGCAGAGATCAGCTGTGTGAAGA       TCGAGAACAGGTTCTTCTGGCAGCCCAGCCCGCCAACATGCATCGCTCCCTGCGGGGGAGACCTGACA       GGACCATCTGGAGTCATCCTCTCACCAAATTACCCAGAACCCTACCCGCCAGGCAAGGAGTGTGACTG       GAAAGTGACCGTCTCACCAGACTACGTCATCGCCCTGGTATTGTTCCCCAGCTTTAACCTGGAGCCTG       GCTATGACTTCCTCCATATCTACGACGGACGGGACTCTCTCAGCCCTCTCATAGGAAGCTTCTATGGC       TCCCAGCTCCCAGGCCGCATTGAAAGCAGCAGCAACAGCCTCTTCCTCGCCTTCCGCAGCGATGCATC       TGTGAGCAATGCTGGCTTCGTCATTGACTTCCCAGAAAACCCGCGGGAGTCATGTTTTGATCCTGGTT       CCATCAAGAACGGCACACGGGTGGGGTCCGACCTGAAGCTGGGCTCCTCCGTCACCTACTACTGCCAC       GGGGGCTACGAAGTTGAGGGCACCTCGACCCTGAGCTGCATCCTGGGGCCTGATGGGAAGCCCGTGTG       GAACAATCCCCGGCCAGTCTGCACAGCCCCCTGTGGGGGACAGTATGTGGGTTCGGACGGAGTGGTCT       TGTCCCCCAACTACCCCCAGAACTACACCAGTGGACAGATCTGCTTGTATTTTGTTACTGTGCCCAAG       GACTATGGTGTGGTGTTTGGCCAGTTCGCCTTCTTTCACACGGCCCTCAACGACGTGGTGGAGGTTCA       CGACGGCCACAGCCAGCACTCGCGGCTCCTCAGCTCCCTCTCGGGCTCCCATACAGGTGGAGAATCAC       TGCCCTTGGCCACCTCCAATCAAGTTCTCATTAAGTTCAGCGCCAAAGGCCTCGCACCAGCCAGAGGC       TTCCACTTTGTCTACCAAGCGGTTCCTCGAACCAGCGCCACGCAGTGCAGCTCTGTGCCGGAACCCCG       CTATGGCAAGAGGCTGGGCAGTGACTTCTCGGTGGGGGCCATCGTCCGCTTCGAATGCAACTCCGGCT       ATGCCCTGCAGGGGTCGCCAGAGATCGAGTGCCTCCCTGTGCCTGGGGCCTTGGCCCAATGGAATGTC       TCAGCGCCCACGTGTGTGGTGCCGTGTGGAGGCAACCTCACAGAGCGCAGGGGCACCATCCTGTCCCC       TGGCTTCCCAGAGCCGTACCTCAACAGCCTCAACTGTGTGTGGAAGATCGTGGTCCCCGAAGGCGCTG       GCATCCAGATCCAAGTTGTCAGTTTTGTGACAGAGCAGAACTGGGACTCGCTGGAAGTATTTGATGGT       GCAGATAACACTGTAACCATGCTGGGGAGTTTCTCAGGAACAACCGTGCCTGCCCTTCTGAACAGCAC       CTCCAACCAGCTCTACCTTCATTTCTACTCAGATATCAGCGTATCTGCAGCTGGCTTCCACTTGGAGT       ACAAAACGGTGGGCCTGAGCAGTTGTCCGGAACCTGCTGTGCCCAGTAACGGGGTGAAGACTGGCGAG       CGCTACTTGGTGAATGATGTGGTGTCTTTCCAGTGTGAGCCGGGATATGCCCTCCAGGGCCACGCCCA       CATCTCCTGCATGCCCGGAACAGTGCGGCGATGGAACTACCCTCCTCCACTCTGTATTGCACAGTGTG       GGGGAACAGTGGAGGAGATGGAGGGGGTGATCCTGAGCCCCGGCTTCCCAGGCAACTACCCCAGTAAC       ATGGACTGCTCCTGGAAAATAGCACTGCCCGTGGGCTTTGGAGCTCACATCCAGTTCCTGAACTTCTC       CACCGAGCCCAACCACGACTACATAGAAATCCGGAATGGCCCCTATGAGACCAGCCGCATGATGGGAA       GATTCAGTGGAAGCGAGCTTCCAAGCTCCCTCCTCTCCACGTCCCACGAGACCACCGTGTATTTCCAC       AGCGACCACTCCCAGAATCGGCCAGGATTCAAGCTGGAGTATCAGGCCTATGAACTTCAAGAGTGCCC       AGACCCAGAGCCCTTTGCCAATGGCATTGTGAGGGGAGCTGGCTACAACGTGGGACAATCAGTGACCT       TCGAGTGCCTCCCGGGGTATCAATTGACTGGCCACCCTGTCCTCACGTGTCAACATGGCACCAACCGG       AACTGGGACCACCCCCTGCCCAAGTGTGAAGTCCCTTGTGGCGGGAACATCACTTCTTCCAACGGCAC       TGTGTACTCCCCGGGGTTCCCTAGCCCGTACTCCAGCTCCCAGGACTGTGTCTGGCTGATCACCGTGC       CCATTGGCCATGGCGTCCGCCTCAACCTCAGCCTGCTGCAGACAGAGCCCTCTGGAGATTTCATCACC       ATCTGGGATGGGCCACAGCAAACAGCACCACGGCTCGGCGTCTTCACCCGGAGCATGGCCAAGAAAAC       AGTGCAGAGTTCATCCAACCAGGTCCTGCTCAAGTTCCACCGTGATGCAGCCACAGGGGGGATCTTCG       CCATAGCTTTCTCCGCTTATCCACTCACCAAATGCCCTCCTCCCACCATCCTCCCCAACGCCGAAGTC       GTCACAGAGAATGAAGAATTCAATATAGGTGACATCGTACGCTACAGATGCCTCCCTGGCTTTACCTT       AGTGGGGAATGAAATTCTGACCTGCAAACTTGGAACCTACCTGCAGTTTGAAGGACCACCCCCGATAT       GTGAAGTGCACTGTCCAACAAATGAGCTTCTGACAGACTCCACAGGCGTGATCCTGAGCCAGAGCTAC       CCTGGAAGCTATCCCCAGTTCCAGACCTGCTCTTGGCTGGTGAGAGTGGAGCCCGACTATAACATCTC       CCTCACAGTGGAGTACTTCCTCAGCGAGAAGCAATATGATGAGTTTGAGATTTTTGATGGTCCATCAG       GACAGAGTCCTCTGCTGAAAGCCCTCAGTGGGAATTACTCAGCTCCCCTGATTGTCACCAGCTCAAGC       AACTCTGTGTACCTGCGTTGGTCATCTGATCACGCCTACAATCGGAAGGGCTTCAAGATCCGCTATTC       AGCCCCTTACTGCAGCCTGCCCAGGGCTCCACTCCATGGCTTCATCCTAGGCCAGACCAGCACCCAGC       CCGGGGGCTCCATCCACTTTGGCTGCAACGCCGGCTACCGCCTGGTGGGACACAGCATGGCCATCTGT       ACCCGGCACCCCCAGGGCTACCACCTGTGGAGCGAAGCCATCCCTCTCTGTCAAGCTCTTTCCTGTGG       GCTTCCTGAGGCCCCCAAGAATGGAATGGTGTTTGGCAAGGAGTACACAGTGGGAACCAAGGCCATGT       ACAGCTGCAGTGAAGGCTACCACCTCCAGGCAGGCGCTGAGGCCACTGCAGAGTGTCTGGACACAGGC       CTATGGAGCAACCGCAATGTCCCACCACAGTGTGTCCCTGTGACTTGTCCTGATGTCAGTAGCATCAG       CGTGGAGCATGGCCGATGGAGGCTTATCTTTGAGACACAGTATCAGTTCCAGGCCCAGCTGATGCTCA       TCTGTGACCCTGGCTACTACTATACTGGCCAAAGGGTCATCCGCTGTCAGGCCAATGGCAAATGGAGC       CTCGGGGACTCTACGCCCACCTGCCGAATCATCTCCTGTGGAGAGCTCCCGATTCCCCCCAATGGCCA       CCGCATCGGAACACTGTCTGTCTACGGGGCAACAGCCATCTTCTCCTGCAATTCCGGATACACACTGG       TGGGCTCCAGGGTGCGTGAGTGCATGGCCAATGGGCTCTGGAGTGGCTCTGAAGTCCGCTGCCTTGCT       GGACACTGTGGGACTCCTGAGCCCATTGTCAACGGACACATCAATGGGGAGAACTACAGCTACCGGGG       CAGTGTGGTGTACCAATGCAATGCTGGCTTCCGCCTGATCGGCATGTCTGTGCGCATCTGCCAGCAGG       ATCATCACTGGTCGGGCAAGACCCCTTTCTGTGTGCTGGTGTCCTGTGGCCATCCGGGCTCCCCGCCT       CACTCCCAGATGTCTGGAGACAGTTATACTGTGGGAGCAGTGGTGCGGTACAGCTGCATCGGCAAGCG       TACTCTGGTGGGAAACAGCACCCGCATGTGTGGGCTGGATGGACACTGGACTGGCTCCCTCCCTCACT       GCTCAGGAACCAGCGTGGGAGTTTGCGGTGACCCTGGGATCCCGGCTCATGGCATCCGTTTGGGGGAC       AGCTTTGATCCAGGCACTGTGATGCGCTTCAGCTGTGAAGCTGGCCACGTGCTCCGGGGATCGTCAGA       GCGCACCTGTCAAGCCAATGGCTCGTGGAGCGGCTCGCAGCCTGAGTGTGGAGTGATCTCTTGTGGGA       ACCCTGGGACTCCAAGTAATGCCCGAGTTGTGTTCAGTGATGGCCTGGTTTTCTCCAGCTCTATCGTC       TATGAGTGCCGGGAAGGATACTACGCCACAGGCCTGCTCAGCCGTCACTGCTCGGTCAATGGTACCTG       GACAGGCAGTGACCCTGAGTGCCTCGTCATAAACTGTGGTGACCCTGGGATTCCAGCCAATGGCCTTC       GGCTGGGCAATGACTTCAGGTACAACAAAACTGTGACATATCAGTGTGTCCCTGGCTATATGATGGAG       TCACATAGAGTATCTGTGCTGAGCTGCACCAAGGACCGGACATGGAATGGAACCAAGCCCGTCTGCAA       AGCTCTCATGTGCAAGCCACCTCCGCTCATCCCCAATGGGAAGGTGGTGGGGTCTGACTTCATGTGGG       GCTCAAGTGTGACTTATGCCTGCCTGGAGGGGTACCAGCTCTCCCTGCCCGCGGTGTTCACCTGTGAG       GGAAATGGGTCCTGGACCGGAGAGCTGCCTCAGTGTTTCCCTGTGTTCTGCGGGGATCCTGGTGTCCC       GTCCCGTGGGAGGAGAGAGGACCGAGGCTTCTCCTACAGGTCATCTGTCTCCTTCTCCTGCCATCCCC       CTCTGGTGCTGGTGGGCTCTCCACGCAGGTTTTGCCAGTCAGATGGGACATGGAGTGGCACCCAGCCC       AGCTGCATAGATCCGACCCTGACCACGTGTGCGGACCCTGGTGTGCCACAGTTTGGGATACAGAACAA       TTCTCAGGGCTACCAGGTTGGAAGCACAGTCCTCTTCCGTTGTCAAAAAGGCTACCTGCTTCAGGGCT       CCACCACCAGGACCTGCCTCCCAAACCTGACCTGGAGTGGAACCCCACCTGACTGTGTCCCCCACCAC       TGCAGGCAGCCAGAGACGCCAACGCATGCCAACGTCGGGGCCCTGGATTTGCCCTCCATGGGCTACAC       GCTCATCTACTCCTGCCAGGAGGGCTTCTCCCTCAAGGGTGGCTCCGAGCACCGCACCTGCAAGGCGG       ATGGCAGCTGGACAGGCAAGCCGCCCATCTGCCTGGAGGTCCGGCCCAATGGGAGACCCATCAACACT       GCCCGGGAGCCACCGCTCACCCAAGCCTTGATTCCTGGGGATGTTTTTGCCAAGAATTCCCTGTGGAA       AGGGGCCTATGAATACCAGGGGAAGAAGCAGCCAGCCATGCTCAGAGTGACTGGCTTCCAAGTTGCCA       ACAGCAAGGTCAATGCCACCATGATCGACCACAGTGGCGTGGAGCTGCACTTGGCTGGAACTTACAAG       AAAGAAGATTTTCATCTCCTACTCCAGGTGTACCAGATTACAGGGCCTGTGGAGATCTTTATGAATAA       GTTCAAAGATGATCACTGGGCTTTAGATGGCCATGTCTCGTCAGAGTCCTCCGGAGCCACCTTCATCT       ACCAAGGCTCTGTCAAGGGCCAAGGCTTTGGGCAGTTCGGCTTTCAAAGACTGGACCTCAGGCTGCTG       GAGTCAGACCCCGAGTCCATTGGCCGCCACTTTGCTTCCAACAGCAGCTCAGTGGCAGCCGCGATCCT       GGTGCCTTTCATCGCCCTCATTATTGCGGGCTTCGTGCTCTATCTCTACAAGCACAGGAGAAGACCCA       AAGTTCCTTTCAATGGCTATGCTGGCCACGAGAACACCAATGTTCGGGCCACATTTGAGAACCCAATG       TACGACCGCAACATCCAGCCCACAGACATCATGGCCAGCGAGGCGGAGTTCACAGTCAGCACAGTGTG       CACAGCAGTA TAG   CCACCCGGCCTGGCCGCCACCACCGCCACCGAGAGCCCCGCCTCCAGCAGCCGTT           CCCCAGGGGGCAGGAAGTAGGCTCCCCTGAGCACAGTGCCCAGTGCCCATCTTCGTTCGTCTCCTTGC           CTGTGTCTGCTACTGCTGGGACTCAGGCCCTCGCCCTGCCGCCATCTATGCCAGTTACCCTGGAGAGG           ACTCCTGCCGTGTCCTGAAAAGGCAGAAAAGGAAGAGGGGCTGCAGACAGAGGAAGAAAGTTTATGGA           TTTAAAATAGCAAAGCAACTTGTGGATCTGTGTGTGTGTGTGTGTGTGTGTGTATGGGCCTGATCACA           CACAAACACACACACCTCTCCTTCATTCACGTCCTATGGAAGAGACCATAAAGGCTTCAAAACTAGAA           GTGCGCATGAAGGATGCTTCATGCCCTGTTCCCCACACAGAGAAGAGATGAAGAGGGGGAGGTACGGT           CAGCTTTCAAAACAATATGCCCCCCGCCCATCCCATGTGTGAGGACATGGTGACTCGGTGACTGTAAC           AGTAGGACACATCCCATCATGCGGTCAGAGTGCAGAAACCCGGTCAGCGTGCAGAAACCAGCTGTCTG           CTGATGAACGGCCCATCTGCACAGCGGCAGCAAGGATTACCCCAAGGGCAGGAAAAAAGTCTTTGGAP           ATAGATTGAAAATCAGTTTCTTTATTTTTTTCAAACACTGTTTTATTGAGTTCTAAACCCAGTGGATT           AAAAAGTCATTTGGGTCCTGGGAAGCACTGGGAAAGAAGGGAGAGCCGGGGAGGATAGGGCAGGAGTC           TGGCCAGGAGCCCAAGGTCAAGTCTGGCTGTCAACTGACAAAGAGAAGAGAAGACAAGTCTGTGGCCC           AGACAGGGTGCCAAGTCTGGGGGCAGCAGCAGGGTCCTTGAGAGAACAGGGGAGCAAGCCTGCCCCAG           TACCCAAAAAACAATGGCTATCATGTACTGGGGTTATTCTCTGTGCCTGACACTTTACCTATAGTATT           TCTAGTCTGCACAATAACACCAAAATGTAGGATTTGTTATTCCCCTTTGACAGATGAGAAAACAGAAG           CCTGCAAAGGTAAAGACAGAGTTAGGAAGTGTGGAGTCAGAATGCAAACCCAGATCAGTCTGCCCCAA           AGTCCACTACACCAGCTGCCAGAAACCCTGTTCTAGAAGGGGCAGCTAAGAAGGGAGGAGCCGATGAA           ACTCTACAGTAGCACTGTGGCCAGGTCTGGAAAGCCAGGCAAGACACCTGTGTGTCCTATCTGGGTTC           TGCTGTCTCCGCGTAGGCAGCTTCGGGGCAAGGATTCAACTCCCCAGGCCTCCCACGGTTGGTGCTGG           CTCCTTGGCTCCCAGCAGCCGCTGACCATAGCCAGCAAAAGACCTGGCAGGTCCTGAATCAAAACAAC           AGAGTGGCTGAAAGTCACACCTCTCCAGCTCCTTGCGAGTGGGTTTGATTGATTTTGACAGCTATATC           ATGCTTGGGTCGTTCATGAATTCCATGAGAATTGTTGGGAAGTTCATGAGTTTAGGAATCAAAGTATA           GCATTTAGGGCCACTTTCTCTGTCCTCGGGAAGGCCCCCACAAGCTTAAGCCCCTGTATACGTGTGAC           ATGCTGGCCTCAGAGATTCATGTCACATATTGAAATAGCAAATAGAAATGTGCAGGAGCGGAGGGACA           GCGACACCTGGTTCTTAAGCAAATTCTAGATTGGAACAATTAGAAGATCTGACTGATGTTAAGAGTGG           CCAGAGGAAAGTGAGAGGCGTCCATTTCCAGCAGACACAATGGAGGCTGACAGAGGCAGGAGCCTACC           CCTGGCCACACCACCTCTGGGACACGGCACCCCCCTGGGCCTGGAGGGAGAGGGCCAATCCAGACACA           CTCACACTCTCATCTCTTTCCTTGGCTGGAAACAAGTGCAGGAAGCTCCCCTCCCAATTTCTTATGCT           CCCTTCCCCCTTACACTCCTCTCCTTCGACTGCTCCCTTCCCCCTTCTTATGCCCCTCTCAGACCACC           CAGCGGATGCCTATTCCCGCCCCCCACCCCTCCCCTGCGTCTCCTTGTAAAGTTCCATGAGATGCTCG           AGGAGCACCTGCTGGTGGGGCACCCAGCACTCTGCTGGGCATCACCCTCCGCACCCCTGACATTTCTC           TCCACCTCCAGAGGCTTGGAAGGGAACAGGGCAGATGAGGCCCTTCACCCACCATCTACAACATATAC           CCATCACCATCCCATGAGGAAAAAAAAAAAAGTAAAACAAAGACAAAAAAAATCTTTTGTACAGAGAT           ATATTTTTATTATACAAAGTTTGTACAGTACCAAAAAAGAAAAAAAAAAGGTGTAAATTTTTTTTTCA           TTATTGTAGGTAAACGGTAGTGGAAGCCTTTTTTGTAAATGTAATAAAATGTATAAATATGGTTTTCA           GAAAACATCAAGTGCTGTAAATATGTAATCTACACACCTTCTTGGCTTGTCTGCAGTATATACATTTA           ATTTATCTGTCTCTGTATATGAGGCTTCCCCCTGGGGTCCTGCATTATGGTACTTTCCTGAATTTGAA           AGCAATTTTAAATTTTTTGAATTCAAATAAAATATAAATTTTTGCATTG                                           NOV4f, CG50377-06   SEQ ID NO: 42   3130 aa   MW at 340344.5kD           Protein Sequence                     MPSKDNSQKTSVVTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKV           SDMFAAWSDHRPVCPARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLE       RGYDTLTVGDGGQDGDQKTVLYMLTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCG       DPGIPAYGRREGSRFRHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVCSCFFNFTSPSGVVL       SPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSIT       SSGHVARLEFQTDHSTGKRGFNITFTSESSNECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQG       SETITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITF       DRFKTEVNYDTLEVPDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYEAITL       QSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEALCGGFIQG       SSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITENGSFTQPLRQLTGSRL       PAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQFGVGDTLTFSCF       PGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGK       GIQLKAEAFELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELH       FSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAE       CGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGPVESGVL       LKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSGSTATSCNDPGIPQNGSRSGDSWEAGDS       TVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGPSGVILSPNYPEPYPPGKECDWK       VTVSPDYVIALVLFPSFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASV       SNAGFVIDFPENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWN       NPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYGVVFGQFAFFHTALNDVVEVHD       GHSQHSRLLSSLSGSHTGGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSVPEPRY       GKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRGTILSPG       FPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTS       NQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHI       SCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFST       EPNHDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQAYELQECPD       PEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSNGTV       YSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTV       QSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLV       GNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISL       TVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSA       PYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGL       PEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISV       EHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHR       IGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGENYSYRGS       VVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRT       LVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSER       TCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWT       GSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKA       LMCKPPPLIPNGKVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPS       RGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNS       QGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHAINGALDLPSMGYTL       IYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPNGRPINTAREPPLTQALIPGDVFAKNSLWKG       AYEYQGKKQPAMLRVTGFQVANSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKF       KDDHWALDGHVSSESSGATFIYQGSVKGQGFGQFGFQRLDLRLLESDPESIGRHFASNSSSVAAAILV       PFIALIIAGFVLYLYKHRRRPKVPFNGYAGHENTNVRATFENPMYDRNIQPTDIMASEAEFTVSTVCT       AV                                     NOV4g, 273095147   SEQ ID NO: 43   2329 bp           DNA Sequence   ORF Start: at 1   ORF Stop: at 2329                     AAGCTTGAGTGCCCAGACCCAGAGCCCTTTGCCAATGGCATTGTGAGGGGAGCTGGCTACAACGTGGG           ACAATCAGTGACCTTCGAGTGCCTCCCGGGGTATCAATTGACTQGCCACCCTGTCCTCACGTGTCAAC       ATGGCACCAACCGGAACTGGGACCACTCCCTGCCCAAGTGTGAAGTCCCTTGTGGCGGGAACATCACT       TCTTCCAACGGCACTGTGTACTCCCCGGGGTTCCCTAGCCCGTACTCCAGCTCCCAGGACTGTGTCTG       GCTGATCACCGTGCCCATTGGCCATGGCGTCCGCCTCAACCTCAGCCTGCTGCAGACAGAGCCCTCTG       GAGATTTCATCACCATCTGGGATGGGCCACAGCAAACAGCACCACGGCTCGGCGTCTTCACCCGGAGC       ATGGCCAAGAAAACAGTGCAGAGTTCATCCAACCAGGTCCTGCTCAAGTTCCACCGTGATGCAGCCAC       AGGGGGGATCTTCGCCATAGCTTTCTCCGCTTATCCACTCACCAAATGCCCTCCTCCCACCATCCTCC       CCAACGCCGAAGTCGTCACAGAGAATGAAGAATTCAATATAGGTGACATCGTACGCTACAGATGCCTC       CCTGGCTTTACCTTAGTGGGGAATGAAATTCTTACCTGCAAACTTGGAACCTACCTGCAGTTTGAAGG       ACCACCCCCGATATGTGAAGTGCACTGTCCAACAAATGAGCTTCTGACAGACTCCACAGGCGTGATCC       TGAGCCAGAGCTACCCTGGAAGCTATCCCCAGTTCCAGACCTGCTCTTGGCTGGTGAGAGTGGAGCCC       GACTATAACATCTCCCTCACAGTGGAGTACTTCCTCAGCGAGAAGCAATATGATGAGTTTGAGATTTT       TGATGGTCCATCAGGACAGAGTCCTCTGCTGAAAGCCCTCAGTGGGAATTACTCAGCTCCCCTGATTG       TCACCAGCTCAAGCAACTCTGTGTACCTGCGTTGGTCATCTGATCACGCCTACAATCGGAAGGGCTTC       AAGATCCGCTATTCAGCCCCTTACTGCAGCCTGCCCAGGGCTCCACTCCATGGCTTCATCCTAGGCCA       GACCAGCACCCAGCCCGGGGGCTCCATCCACTTTGGCTGCAACGCCGGCTACCGCCTGGTGGGACACA       GCATGGCCATCTGTACCCGGCACCCCCAGGGCTACCACCTGTGGAGCGAAGCCATCCCTCTCTGTCAA       GCTCTTTCCTGTGGGCTTCCTGAGGCCCCCAAGAATGGAATGGTGTTTGGCAAGGAGTACACAGTGGG       AACCAAGGCCATGTACAGCTGCAGTGAAGGCTACCACCTCCAGGCAGGCGCTGAGGCCACTGCAGAGT       GTCTGGACACAGGCCTATGGAGCAACCGCAATGTCCCACCACAGTGTGTCCCTGTGACTTGTCCTGAT       GTCAGTAGCATCAGCGTGGAGCATGGCCGATGGAGGCTTATCTTTGAGACACAGTATCAGTTCCAGGC       CCAGCTGATGCTCATCTGTGACCCTGGCTACTACTATACTGGCCAAAGGGTCATCCGCTGTCAGGCCA       ATGGCAAATGGAGCCTCGGGGACTCTACGCCCACCTGCCGAATCATCTCCTGTGGAGAGCTCCCGATT       CCCCCCAATGGCCACCGCATCGGAACACTGTCTGTCTACGGGGCAACAGCCATCTTCTCCTGCAATTC       CGGATACACACTGGTGGGCTCCAGGGTGCGTGAGTGCATGGCCAATGGGCTCTGGAGTGGCTCTGAAG       TCCGCTGCCTTGCTGGACACTGTGGGACTCCTGAGCCCATTGTCAACGGACACATCAATGGGGAGAAC       TACAGCTACCGGGGCAGTGTGGTGTACCAATGCAATGCTGGCTTCCGCCTGATCGGCATGTCTGTGCG       CATCTGCCAGCAGGATCATCACTGGTCGGGCAAGACCCCTTTCTGTGTGCCAATTACCTGTGGACACC       CAGGCAACCCTGTCAACGGCCTCACCCAGGGTAACCAGTTTAACCTCAACGATGTGGTCAAGTTTGTT       TGCAACCCTGGGTATATGGCTGAGGGGGCTGCTAGGTCCCAATGCCTGGCCAGCGGGCAGTGGAGTGA       CATGCTGCCCACCTGCAGAATCATCAACTGTACAGATCCTGGACACCAAGAAAATAGTGTTCGTCAGG       TCCACGCCAGCGGCCCGCACAGGTTCAGCTTCGGCACCACTGTGTCTTACCGGTGCAACCACGGCTTC       TACCTCCTGGGCACCCCAGTGCTCAGCTGCCAGGGAGATGGCACATGGGACCGTCCCCGCCCCCAGTG       TCTCTGTAAGGTCGACC                                         NOV4g, 273095147   SEQ ID NO: 44   776 aa   MW at 84741.1kD           Protein Sequence                     KLECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHSLPKCEVPCGGNIT           SSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRS       MAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCL       PGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEP       DYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGF       KIRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQ       ALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPD       VSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPI       PPNGGRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGEN       YSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFV       CNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGF       YLLGTPVLSCQGDGTWDRPRPQCLCKVD                                     Nov4h, 317459653   SEQ ID NO: 45   2328 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     AAGCTTGAGTGCCCAGACCCAGAGCCCTTTGCCAATGGCATTGTGAGGGGAGCTGGCTACAACGTGGG           ACAATCAGTGACCTTCGAGTGCCTCCCGGGGTATCAATTGACTGGCCACCCTGTCCTCACGTGTCAAC       ATGGCACCAACCGGAACTGGGACCACCCCCTGCCCAAGTGTGAAGTCCCTTGTGGCGGGAACATCACT       TCTTCCAACGGCACTGTGTACTCCCCGGGGTTCCCTAGCCCGTACTCCAGCTCCCAGGACTGTGTCTG       GCTGATCACCGTGCCCATTGGCCATGGCGTCCGCCTCAACCTCAGCCTGCTGCAGACAGAGCCCTCTG       GAGATTTCATCACCATCTGGGATGGGCCACAGCAAACAGCACCACGGCTCGGCGTCTTCACCCGGAGC       ATGGCCAAGAAAACAGTGCAGAGTTCATCCAACCAGGTCCTGCTCAAGTTCCACCGTGATGCAGCCAC       AGGGGGGATCTTCGCCATAGCTTTCTCCGCTTATCCACTCACCAAATGCCCTCCTCCCACCATCCTCC       CCAACGCCGAAGTCGTCACAGAGAATGAAGAATTCAATATAGGTGACATCGTACGCTACAGATGCCTC       CCTGGCTTTACCTTAGTGGGGAATGAAATTCTGACCTGCAAACTTGGAACCTACCTGCAGTTTGAAGG       ACCACCCCCGATATGTGAAGTGCACTGTCCAACAAATGAGCTTCTGACAGACTCCACAGGCGTGATCC       TGAGCCAGAGCTACCCTGGAAGCTATCCCCAGTTCCAGACCTGCTCTTGGCTGGTGAGAGTGGAGCCC       GACTATAACATCTCCCTCACAGTGGAGTACTTCCTCAGCGAGAAGCAATATGATGAGTTTGAGATTTT       TGATGGTCCATCAGGACAGAGTCCTCTGCTGAAAGCCCTCAGTGGGAATTACTCAGCTCCCCTGATTG       TCACCAGCTCAAGCAACTCTGTGTACCTGCGTTGGTCATCTGATCACGCCTACAATCGGAAGGGCTTC       AAGATCCGCTATTCAGCCCCTTACTGCAGCCTGCCCAGGGCTCCACTCCATGGCTTCATCCTAGGCCA       GACCAGCACCCAGCCCGGGGGCTCCATCCACTTTGGCTGCAACGCCGGCTACCGCCTGGTGGGACACA       GCATGGCCATCTGTACCCGGCACCCCCAGGGCTACCACCTGTGGAGCGAAGCCATCCCTCTCTGTCAA       GCTCTTTCCTGTGGGCTTCCTGAGGCCCCCAAGAATGGAATGGTGTTTGGCAAGGAGTACACAGTGGG       AACCAAGGCCGTGTACAGCTGCAGTGAAGGCTACCACCTCCAGGCAGGCGCTGAGGCCACTGCAGAGT       GTCTGGACACAGGCCTATGGAGCAACCGCAATGTCCCACCACAGTGTGTCCCTGTGACTTGTCCTGAT       GTCAGTAGCATCAGCGTGGAGCATGGCCGATGGAGGCTTATCTTTGAGACACAGTATCAGTTCCAGGC       CCAGCTGATGCTCATCTGTGACCCTGGCTACTACTATACTGGCCAAAGGGTCATCCGCTGTCAGGCCA       ATGGCAAATGGAGCCTCGGGGACTCTACGCCCACCTGCCGAATCATCTCCTGTGGAGAGCTCCCGATT       CCCCCCAATGGCCACCGCATCGGAACACTGTCTGTCTACGGGGCAACAGCCATCTTCTCCTGCAATTC       CGGATACACACTGGTGGGCTCCAGGGTGCGTGAGTGCATGGCCAATGGGCTCTGGAGTGGCTCTGAAG       TCCGCTGCCTTGCTGGACACTGTGGGACTCCTGAGCCCATTGTCAACGGACACATCAATGGGGAGAAC       TACAGCTACCGGGGCAGTGTGGTGTACCAATGCAATGCTGGCTTCCGCCTGATCGGCATGTCTGTGCG       CATCTGCCAGCAGGATCATCACTGGTCGGGCAAGACCCCTTTCTGTGTGCCAATTACCTGTGGACACC       CAGGCAACCCTGTCAACGGCCTCACTCAGGGTAACCAGTTTAACCTCAACGATGTGGTCAAGTTTGTT       TGCAACCCTGGGTATATGGCTGAGGGGGCTGCTAGGTCCCAATGCCTGGCCAGCGGGCAATGGAGTGA       CATGCTGCCCACCTGCAGAATCATCAACTGTACAGATCCTGGACACCAAGAAAATAGTGTTCGTCAGG       TCCACGCCAGCGGCCCGCACAGGTTCAGCTTCGGCACCACTGTGTCTTACCGGTGCAACCACGGCTTC       TACCTCCTGGGCACCCCAGTGCTCAGCTGCCAGGGAGATGGCACATGGGACCGTCCCCGCCCCCAGTG       TCTCTGTAAGGTCGAC                                         NOV4h, 317459653   SEQ ID NO: 46   776 aa   MW at 84719.1kD           Protein Sequence                     KLECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNIT           SSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRS       MAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCL       PGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEP       DYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGF       KIRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQ       ALSCGLPEAPKNGMVFGKEYTVGTKAVYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPD       VSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPI       PPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGEN       YSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFV       CNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGF       YLLGTPVLSCQGDGTWDRPRPQCLCKVD                                     NOV4i, 317459612   SEQ ID NO: 47   2139 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     AAGCTTGAGTGCCCAGACCCAGAGCCCTTTGCCAATGGCATTGTGAGGGGAGCTGGCTACAACGTGGG           ACAATCAGTGACCTTCGAGTGCCTCCCGGGGTATCAATTGACTGGCCACCCTGTCCTCACGTGTCAAC       ATGGCACCAACCGGAACTGGGACCACCCCCTGCCCAAGTGTGAAGTCCCTTGTGGCGGGAACATCACT       TCTTCCAACGGCACTGTGTACTCCCCGGGGTTCCCTAGCCCGTACTCCAGCTCCCAGGACTGTGTCTG       GCTGATCACCGTGCCCATTGGCCATGGCGTCCGCCTCAACCTCAGCCTGCTGCAGACAGAGCCCTCTG       GAGATTTCATCACCATCTGGGATGGGCCACAGCAAACAGCACCACGGCTCGGCGTCTTCACCCGGAGC       ATGGCCAAGAAAACAGTGCAGAGTTCATCCAACCAGGTCCTGCTCAAGTTCCACCGTGATGCAGCCAC       AGGGGGGATCTTCGCCATAGCTTTCTCCGCTTATCCACTCACCAAATGCCCTCCTCCCACCATCCTCC       CCAACGCCGAAGTCGTCACAGAGAATGAAGAATTCAATATAGGTGACATCGTACGCTACAGATGCCTC       CCTGGCTTTACCTTAGTGGGGAATGAAATTCTGACCTGCAAACTTGGAACCTACCTGCAGTTTGAAGG       ACCACCCCCGATATGTGAAGTGCACTGTCCAACAAATGAGCTTCTGACAGACTCCACAGGCGTGATCC       TGAGCCAGAGCTACCCTGGAAGCTATCCCCAGTTCCAGACCTGCTCTTGGCTGGTGAGAGTGGAGCCC       GACTATAACATCTCCCTCACAGTGGAGTACTTCCTCAGCGAGAAGCAATATGATGAGTTTGAGATTTT       TGATGGTCCATCAGGACAGAGTCCTCTGCTGAAAGCCCTCAGTGGGAATTACTCAGCTCCCCTGATTG       TCACCAGCTCAAGCAACTCTGTGTACCTGCGTTGGTCATCTGATCACGCCTACAATCGGAAGGGCTTC       AAGATCCGCTATTCAGCTCTTTCCTGTGGGCTTCCTGAGGCCCCCAAGAATGGAATGGTGTTTGGCAA       GGAGTACACAGTGGGAACCAAGGCCATGTACAGCTGCAGTGAAGGCTACCACCTCCAGGCAGGCGCTG       AGGCCACTGCAGAGTGTCTGGACACAGGCCTATGGAGCAACCGCAATGTCCCACCACAGTGTGTCCCT       GTGACTTGTCCTGATGTCAGTAGCATCAGCGTGGAGCATGGCCGATGGAGGCCTATCTTTGAGACACA       GTATCAGTTCCAGGCCCAGCTGATGCTCATCTGTGACCCTGGCTACTACTATACTGGCCAAAGGGTCA       TCCGCTGTCAGGCCAATGGCAAATGGAGCCTCGGGGACTCTACGCCCACCTGCCGAATCATCTCCTGT       GGAGAGCTCCCGATTCCCCCCAATGGCCACCGCATCGGAACACTGTCTGTCTACGGGGCAACAGCCAT       CTTCTCCTGCAATTCCGGATACACACTGGTGGGCTCCAGGGTGCGTGAGTGCATGGCCAATGGGCTCT       GGAGTGGCTCTGAAGTCCGCTGCCTTGCTGGACACTGTGGGACTCCTGAGCCCATTGTCAACGGACAC       ATCAATGGGGAGAACTACAGCTACCGGGGCAGTGTGGTGTACCAATGCAATGCTGGCTTCCGCCTGAT       CGGCATGTCTGTGCGCATCTGCCAGCAGGATCATCACTGGTCGGGCAAGACCCCTTTCTGTGTGCCAA       TTACCTGTGGACACCCAGGCAACCCTGTCAACGGCCTCACTCAGGGTAACCAGTTTAACCTCAACGAT       GTGGTCAAGTTTGTTTGCAACCCTGGGTATATGGCTGAGGGGGCTGCTAGGTCCCAATGCCTGGCCAG       CGGGCAATGGAGTGACATGCTGCCCACCTGCAGAATCATCAACTGTACAGATCCTGGACACCAAGAAA       ATAGTGTTCGTCAGGTCCACGCCAGCGGCCCGCACAGGTTCAGCTTCGGCACCACTGTGTCTTACCGG       TGCAACCACGGCTTCTACCTCCTGGGCACCCCAGTGCTCAGCTGCCAGGGAGATGGCACATGGGACCG       TCCCCGCCCCCAGTGTCTCTGTAAGGTCGAC                                         NOV4i, 317459612   SEQ ID NO: 48   713 aa   MW at 77947.4kD           Protein Sequence                     KLECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNIT           SSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFTTIWDGPQQTAPRLGVFTRS       MAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCL       PGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEP       DYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGF       KIRYSALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVP       VTCPDVSSISVEHGRWRPIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISC       GELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGH       INGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQFNLND       VVKFVCNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYR       CNHGFYLLGTPVLSCQGDGTWDRPRPQCLCKVD                                     NOV4j, 317286331   SEQ ID NO: 49   2607 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     AAGCTTTCATGTTTTGATCCTGGTTCCATCAAGAACGGCACACGGGTGGGGTCCGACCTGAAGCTGGG           CTCCTCCGTCACCTACTACTGCCACGGGGGCTACGAAGTTGAGGGCACCTCGACCCTGAGCTGCATCC       TGGGGCCTGATGGGAAGCCCGTGTGGAACAATCCCCGGCCAGTCTGCACAGCCCCCTGTGGGGGACAG       TATGTGGGTTCGGACGGAGTGGTCTTGTCCCCCAACTACCCCCAGAACTACACCAGTGGACAGATCTG       CTTGTATTTTGTTACTGTGCCCAAGGACTATGTGGTGTTTGGCCAGTTCGCCTTCTTTCACACGGCCC       TCAACGACGTGGTGGAGGTTCACGACGGCCACAGCCAGCACTCGCGGCTCCTCAGCTCCCTCTCGGGC       TCCCATACAGGAGAATCACTGCCCTTGGCCACCTCCAATCAAGTTCTCATTAAGTTCAGCGCCAAAGG       CCTCGCACCAGCCAGAGGCTTCCACTTTGTCTACCAAGCGGTTCCTCGAACCAGCGCCACGCAGTGCA       GCTCTGTGCCGGAACCCCGCTATGGCAAGAGGCTGGGCAGTGACTTCTCGGTGGGGGCCATCGTCCGC       TTCGAATGCAACTCCGGCTATGCCCTGCAGGGGTCGCCAGAGATCGAGTGCCTCCCTGTGCCTGGGGC       CTTGGCCCAATGGAATGTCTCAGCGCCCACGTGTGTGGTGCCGTGTGGAGGCAACCTCACAGAGCGCA       GGGGCACCATCCTGTCCCCTGGCTTCCCAGAGCCGTACCTCAACAGCCTCAACTGTGTGTGGAAGATC       GTGGTCCCCGAAGGCGCTGGCATCCAGATCCAAGTTGTCAGTTTTGTGACAGAGCAGAACTGGGACTC       GCTGGAAGTATTTGATGGTGCAGATAACACTGTAACCATGCTGGGGAGTTTCTCAGGAACAACCGTGC       CTGCCCTTCTGAACAGCACCTCCAACCAGCTCTACCTTCATTTCTACTCAGATATCAGCGTATCTGCA       GCTGGCTTCCACTTGGAGTACAAAACGGTGGGCCTGAGCAGTTGTCCGGAACCTGCTGTGCCCAGTAA       CGGGGTGAAGACTGGCGAGCGCTACTTGGTGAATGATGTGGTGTCTTTCCAGTGTGAGCCGGGATATG       CCCTCCAGGGCCACGCCCACATCTCCTGCATGCCCGGAACAGTGCGGCGATGGAACTACCCTCCTCCA       CTCTGTATTGCACAGTGTGGGGGAACAGTGGAGGAGATGGAGGGGGTGATCCTGAGCCCCGGCTTCCC       AGGCAACTACCCCAGTAACATGGACTGCTCCTGGAAAATAGCACTGCCCGTGGGCTTTGGAGCTCACA       TCCAGTTCCTGAACTTCTCCACCGAGCCCAACCACGACTACATAGAAATCCGGAATGGCCCCTATGAG       ACCAGCCGCATGATGGGAAGATTCAGTGGAAGCGAGCTTCCAAGCTCCCTCCTCTCCACGTCCCACGA       GACCACCGTGTATTTCCACAGCGACCACTCCCAGAATCGGCCAGGATTCAAGCTGGAGTATCAGGCCT       ATGAACTTCAAGAGTGCCCAGACCCAGAGCCCTTTGCCAATGGCATTGTGAGGGGAGCTGGCTACAAC       GTGGGACAATCAGTGACCTTCGAGTGCCTCCCGGGGTATCAATTGACTGGCCACCCTGTCCTCACGTG       TCAACATGGCACCAACCGGAACTGGGACCACCCCCTGCCCAAGTGTGAAGTCCCTTGTGGCGGGAACA       TCACTTCTTCCAACGGCACTGTGTACTCCCCGGGGTTCCCTAGCCCGTACTCCAGCTCCCAGGACTGT       GTCTGGCTGATCACCGTGCCCATTGGCCATGGCGTCCGCCTCAACCTCAGCCTGCTGCAGACAGAGCC       CTCTGGAGATTTCATCACCATCTGGGATGGGCCACAGCAAACAGCACCACGGCTCGGCGTCTTCACCC       GGAGCATGGCCAAGAAAACAGTGCAGAGTTCATCCAACCAGGTCCTGCTCAAGTTCCACCGTGATGCA       GCCACAGGGGGGATCTTCGCCATAGCTTTCTCCGCTTATCCACTCACCAAATGCCCTCCTCCCACCAT       CCTCCCCAACGCCGAAGTCGTCACAGAGAATGAAGAATTCAATATAGGTGACATCGTACGCTACAGAT       GCCTCCCTGGCTTTACCTTAGTGGGGAATGAAATTCTGACCTGCAAACTTGGAACCTACCTGCAGTTT       GAAGGACCACCCCCGATATGTGAAGTGCACTGTCCAACAAATGAGCTTCTGACAGACTCCACAGGCGT       GATCCTGAGCCAGAGCTACCCTGGAAGCTATCCCCAGTTCCAGACCTGCTCTTGGCTGGTGAGAGTGG       AGCCCGACTATAACATCTCCCTCACAGTGGAGTACTTCCTCAGCGAGAAGCAATATGATGAGTTTGAG       ATTTTTGATGGTCCATCAGGACAGAGTCCTCTGCTGAAAGCCCTCAGTGGGAATTACTCAGCTCCCCT       GATTGTCACCAGCTCAAGCAACTCTGTGTACCTGCGTTGGTCATCTGATCACGCCTACAATCGGAAGG       GCTTCAAGATCCGCTATGTCGAC                                         NOVv4j, 317286331   SEQ ID NO: 50   869 aa   MW at 94553.5kD           Protein Sequence                     KLSCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCGGQ           YVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSG       SHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVR       FECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKI       VVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSA       AGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPP       LCIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGPYE       TSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQAYELQECPDPEPFANGIVRGAGYN       VGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSNGTVYSPGFPSPYSSSQDC       VWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDA       ATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQF       EGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFE       IFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYVD                                     NOV4k, CG50377-07   SEQ ID NO: 51   300 bp           DNA Sequence   ORF Start: at 2   ORF Stop: at 299                     AAAGTCATCTGTCTCCTTCTCCTGCCATCCCCCTCTGGTGCTGGTGGGCTCTCCACGCAGGTTTTGCC           AGTCAGATGGGACATGGAGTGGCACCCAGCCCAGCTGCATAGATCCGACCCTGACCACGTGTGCGGAC       CCTGGTGTGCCACAGTTTGGGATACAGAACAATTCTCAGGGCTACCAGGTTGGAAGCACAGTCCTCTT       CCGTTGTCAAAAAGGCTACCTGCTTCAGGGCTCCACCACCAGGACCTGCCTCCCAAACCTGACCTGGA       GTGGAACCCCACCTGACTGTGTGCCCCA                                         NOV4k, CG50377-07   SEQ ID NO: 52   99 aa   MW at 10565.8kD           Protein Sequence                     KSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLF           RCQKGYLLQSTTRTCLPNLTWSGTPPDCVP                                     NOV4l, CG50377-08   SEQ ID NO: 53   1792 bp           DNA Sequence   ORF Start: at 1   ORF Stop: at 1792                     GCTGAGGGGGCTGCTAGGTCCCAATGCCTGGCCAGCGGGCAGTGGAGTGACATGCTGCCCACCTGCAG           AATCATCAACTGTACAGATCCTGGACACCAAGAAAATAGTGTTCGTCAGGTCCACGCCAGCGGCCCGC       ACAGGTTCAGCTTCGGCACCACTGTGTCTTACCGGTGCAACCACGGCTTCTACCTCCTGGGCACCCCA       GTGCTCAGCTGCCAGGGAGATGGCACATGGGACCGTCCCCGCCCCCAGTGTCTCTTGGTGTCCTGTGG       CCATCCGGGCTCCCCGCCTCACTCCCAGATGTCTGGAGACAGTTATACTGTGGGAGCAGTGGTGCGGT       ACAGCTGCATCGGCAAGCGTACTCTGGTGGGAAACAGCACCCGCATGTGTGGGCTGGATGGACACTGG       ACTGGCTCCCTCCCTCACTGCTCAGGAACCAGCGTGGGAGTTTGCGGTGACCCTGGGATCCCGGCTCA       TGGCATCCGTTTGGGGGACAGCTTTGATCCAGGCACTGTGATGCGCTTCAGCTGTGAAGCTGGCCACG       TGCTCCGGGGATCGTCAGAGCGCACCTGTCAAGCCAATGGCTCGTGGAGCGGCTCGCAGCCTGAGTGT       GGAGTGATCTCTTGTGGGAACCCTGGGACTCCAAGTAATGCCCGAGTTGTGTTCAGTGATGGCCTGGT       TTTCTCCAGCTCTATCGTCTATGAGTGCCGGGAAGGATACTACGCCACAGGCCTGCTCAGCCGTCACT       GCTCGGTCAATGGTACCTGGACAGGCAGTGACCCTGAGTGCCTCGTCATAAACTGTGGTGACCCTGGG       ATTCCAGCCAATGGCCTTCGGCTGGGCAATGACTTCAGGTACAACAAAACTGTGACATATCAGTGTGT       CCCTGGCTATATGATGGAGTCACATAGAGTATCTGTGCTGAGCTGCACCAAGGACCGGACATGGAATG       GAACCAAGCCCGTCTGCAAAGCTCTCATGTGCAAGCCACCTCCGCTCATCCCCAATGGGAAGGTGGTG       GGGTCTGACTTCATGTGGGGCTCAAGTGTGACTTATGCCTGCCTGGAGGGGTACCAGCTCTCCCTGCC       CGCGGTGTTCACCTGTGAGGGAAATGGGTCCTGGACCGGAGAGCTGCCTCAGTGTTTCCCTGTGTTCT       GCGGGGATCCTGGTGTCCCGTCCCGTGGGAGGAGAGAGGACCGAGGCTTCTCCTACAGGTCATCTGTC       TCCTTCTCCTGCCATCCCCCTCTGGTGCTGGTGGGCTCTCCACGCAGGTTTTGCCAGTCAGATGGGAC       ATGGAGTGGCACCCAGCCCAGCTGCATAGATCCGACCCTGACCACGTGTGCGGACCCTGGTGTGCCAC       AGTTTGGGATACAGAACAATTCTCAGGGCTACCAGGTTGGAAGCACAGTCCTCTTCCGTTGTCAAAAA       GGCTACCTGCTTCAGGGCTCCACCACCAGGACCTGCCTCCCAAACCTGACCTGGAGTGGAACCCCACC       TGACTGTGTCCCCCACCACTGCAGGCAGCCAGAGACGCCAACGCATGCCAACGTCGGGGCCCTGGATT       TGCCCTCCATGGGCTACACGCTCATCTACTCCTGCCAGGAGGGCTTCTCCCTCAAGGGTGGCTCCGAG       CACCGCACCTGCAAGGCGGATGGCAGCTGGACAGGCAAGCCGCCCATCTGCCTGGAGGTCCGGCCCAG       TGGGAGACCCATCAACATTGCCCGGGAGCCACCGCTCACCCAAGCCTTGATTCCTGGGGATGTTTTTG       CCAAGAATTCCCTGTGGAAAGGGG                                         NOV4l, CG50377-08   SEQ ID NO: 54   597 aa   MW at 63914.5kD           Protein Sequence                     AEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTP           VLSCQGDGTWDRPRPQCLLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHW       TGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPEC       GVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPG       IPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALNCKPPPLIPNGKVV       GSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGFSYRSSV       SFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQK       GYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGYTLIYSCQEGFSLKGGSE       HRTCKADGSWTGKPPICLEVRPSGRPINIAREPPLTQALIPGDVFAKNSLWKG                                     NOV4m, CG50377-09   SEQ ID NO: 55   1135 bp           DNA Sequence   ORF Start: ATG at 510   ORF Stop: TAG at 1044                       TTAAGAACCAGGTGTCGCTGTCCCTCCGCTCCTGCACATTTCTATTTGGTATTTCAATATGTGACATG               AATCTTGAGGCCAGCATGTCACACGTATACAGGGGCTTAAGCTTGTGGGGGCCTTCCCGAGGACAGAG           AAAGTGGCCCTAAATGCTATACTTTGATTCCTAAACTCATGAACTTCCCAACAATTCTCATGGAATTC           ATGAACGACCCAAGCATGATGGGACATGGAGTGGCACCCAGCCCAGCTGCATAGATCCGACCCTGACC           ACGTGTGCGGACCCTGGTGTGCCACAGTTTGGGATACAGAACAATTCTCAGGGCTACCAGGTTGGAAG           CACAGTCCTCTTCCGTTGTCAAAAAGGCTACCTGCTTCAGGGCTCCACCACCAGGACCTGCCTCCCAA           ACCTGACCTGGAGTGGAACCCCACCTGACTGTGTCCCCCACCACTGCAGGCAGCCAGAGACGCCAACG           CATGCCAACGTCGGGGCCCTGGATTTGCCCTCC   ATG GGCTACACGCTCATCTACTCCTGCCAGGAGGG       CTTCTCCCTCAAGGGTGGCTCCGAGCACCGCACCTGCAAGGCGGATGGCAGCTGGACAGGCAAGCCGC       CCATCTGCCTGGAGGTCCGGCCCAGTGGGAGACCCATCAACACTGCCCGGGAGCCACCGCTCACCCAA       GCCTTGATTCCTGGGGATGTTTTTGCCAAGAATTCCCTGTGGAAAGGGGCCTATGAATACCAGGGGAA       GAAGCAGCCAGCCATGCTCAGAGTGACTGGCTTCCAAGTTGCCAACAGCAAGGTCAATGCCACCATGA       TCGACCACAGTGGCGTGGAGCTGCACTTGGCTGGAACTTACAAGAAAGAAGATTTTCATCTCCTACTC       CAGGTGTACCAGATTACAGGGCCTGTGGAGATCTTTATGAATAAGTTCAAAGATGATCACTGGGCTTT       AGATGGCCATGTAAGTTCAGCAAACTCACCTCCTCCCCTGACTCCCAGATCACTGGCAGGGAAGAGGA       GGACAAAAGGGTGTGCAAACCCC TAG   GATCAATCTGGCAACTTGGGAGGAGGTTTTCTGTGGGGCCCT           GCCTAGGAGCAGCAAGAGGATCCTCATCTGCTAATGAAATAGGCAAA                                           NOV4m, CG50377-09   SEQ ID NO: 56   178 aa   MW at 19569.2kD           Protein Sequence                     MGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPSGRPINTAREPPLTQALIPGDVFAKN           SLWKGAYEYQGKKQPAMLRVTGFQVANSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEI       FMNKFKDDHWALDGHVSSANSPPPLTPRSLAGKRRTKGCANP                                     NOV4n, CG50377-10   SEQ ID NO: 57   3905 bp           DNA Sequence   ORF Start: ATG at 427   ORF Stop: TGA at 3079                       GGATTTGAGAGCCTGAACTTAGCCATACACCAGATCTACCTTTGGACCGCAAAAGGGACCCAGTGCTT               CATGAAGCTGGTTTTTTTTGTTTTGTTTTGTTTTTTTTCCGTTGTTTTGTTTCGGCTTTACCAACCTG           ACTGGGTGTTTTTCAATATCCACCATTCAGACTTTCCTCAACAGCAGAGGATGTGGCAGTGGCAAAGA           CAAGGGGATGGGGGGAGACGAAAGGGAAAGGGGCCTGCATGAAAGACCATGTCTGTCTTCCTGCTGGT           GCCAGTTCCCTGAACCTCATCTTGTTGTTCAGCCCCTTACTGCAGCCTGCCCAGGGCTCCACTCCATG           GCTTCATCCTAGGCCAGACCAGCACCCAGCCCGGGGGCTCCATCCACTTTGGCTGCAACGCCGGCTAC           CGCCTGGTGGGACACAGC   ATG GCCATCTGTACCCGGCACCCCCAGGGCTACCACCTGTGGAGCGAAGC       CATCCCTCTCTGTCAAGCTCTTTCCTGTGGGCTTCCTGAGGCCCCCAAGAATGGAJJGGTGTTTGGCA       AGGAGTACACAGTGGGAACCAAGGCCGTGTACAGCTGCAGTGAAGGCTACCACCTCCAGGCAGGCGCT       GAGGCCACTGCAGAGTGTCTGGACACAGGCCTATGGAGCAACCGCAATGTCCCACCACAGTGTGTCCC       TGTGACTTGTCCTGATGTCAGTAGCATCAGCGTGGAGCATGGCCGATGGAGGCTTATCTTTGAGACAC       AGTATCAGTTCCAGGCCCAGCTGATGCTCATCTGTGACCCTGGCTACTACTATACTGGCCAAAGGGTC       ATCCGCTGTCAGGCCAATGGCAAATGGAGCCTCGGGGACTCTACGCCCACCTGCCGAATCATCTCCTG       TGGAGAGCTCCCGATTCCCCCCAATGGCCACCGCATCGGAACACTGTCTGTCTACGGGGCAACAGCCA       TCTTCTCCTGCAATTCCGGATACACACTGGTGGGCTCCAGGGTGCGTGAGTGCATGGCCAATGGGCTC       TGGAGTGGCTCTGAAGTCCGCTGCCTTGCTGGACACTGTGGGACTCCTGAGCCCATTGTCAACGGACA       CATCAATGGGGAGAACTACAGCTACCGGGGCAGTGTGGTGTACCAATGCAATGCTGGCTTCCGCCTGA       TCGGCATGTCTGTGCGCATCTGCCAGCAGGATCATCACTGGTCGGGCAAGACCCCTTTCTGTGTGCCA       ATTACCTGTGGACACCCAGGCAACCCTGTCAACGGCCTCACTCAGGGTAACCAGTTTAACCTCAACGA       TGTGGTCAAGTTTGTTTGCAACCCTGGGTATATGGCTGAGGGGGCTGCTAGGTCCCAATGCCTGGCCA       GCGGGCAATGGAGTGACATGCTGCCCACCTGCAGAATCATCAACTGTACAGATCCTGGACACCAAGAA       AATAGTGTTCGTCAGGTCCACGCCAGCGGCCCGCACAGGTTCAGCTTCGGCACCACTGTGTCTTACCG       GTGCNNAACCACGGCTTCTACCTCCTGGGCAACCCCAGTGCTCAGCTGCCAGGGAGATGGCACATGGG       ACCGTCCCCGCCCCCAGTGTCTCTTGGTGTCCTGTGGCCATCCGGGCTCCCCGCCTCACTCCCAGATG       TCTGGAGACAGTTATACTGTGGGAGCAGTGGTGCGGTACAGCTGCATCGGCAAGCGTACTCTGGTGGG       AAACAGCACCCGCATGTGTGGGCTGGATGGACACTGGACTGGCTCCCTCCCTCACTGCTCAGGAACCA       GCGTGGGAGTTTGCGGTGACCCTGGGATCCCGGCTCATGGCATCCGTTTGGGGGACAGCTTTGATCCA       GGCACTGTGATGCGCTTCAGCTGTGAAGCTGGCCACGTGCTCCGGGGATCGTCAGAGCGCACCTGTCA       AGCCAATGGCTCGTGGAGCGGCTCGCAGCCTGAGTGTGGAGTGATCTCTTGTGGGAACCCTGGGACTC       CAAGTAATGCCCGAGTTGTGTTCAGTGATGGCCTGGTTTTCTCCAGCTCTATCGTCTATGAGTGCCGG       GAAGGATACTACGCCACAGGCCTGCTCAGCCGTCACTGCTCGGTCAATGGTACCTGGACAGGCAGTGA       CCCTGAGTGCCTCGTCATAAACTGTGGTGACCCTGGGATTCCAGCCAATGGCCTTCGGCTGGGCAATG       ACTTCAGGTACAACAAAACTGTGACATATCAGTGTGTCCCTGGCTATATGATGGAGTCACATAGAGTA       TCTGTGCTGAGCTGCACCAAGGACCGGACATGGAATGGAACCAAGCCCGTCTGCAAAGCTCTCATGTG       CAAGCCACCTCCGCTCATCCCCAATGGGAAGGTGGTGGGGTCTGACTTCATGTGGGGCTCAAGTGTGA       CTTATGCCTGCCTGGAGGGGTACCAGCTCTCCCTGCCCGCGGTGTTCACCTGTGAGGGAAATGGGTCC       TGGACCGGAGAGCTGCCTCAGTGTTTCCCTGTGTTCTGCGGGGATCCTGGTGTCCCGTCCCGTGGGAG       GAGAGAGGACCGAGGCTTCTCCTACAGGTCATCTGTCTCCTTCTCCTGCCATCCCCCTCTGGTGCTGG       TGGGCTCTCCACGCAGGTTTTGCCAGTCAGATGGGACATGGAGTGGCACCCAGCCCAGCTGCATAGAT       CCGACCCTGACCACGTGTGCGGACCCTGGTGTGCCACAGTTTGGGATACAGAACAATTCTCAGGGCTA       CCAGGTTGGAAGCACAGTCCTCTTCCGTTGTCAAAAAGGCTACCTGCTTCAGGGCTCCACCACCAGGA       CCTGCCTCCCAAACCTGACCTGGAGTGGAACCCCACCTGACTGTGTCCCCCACCACTGCAGGCAGCCA       GAGACGCCAACGCATGCCAACGTCGGGGCCCTGGATTTGCCCTCCATGGGCTACACGCTCATTACTCC       TGCCAGGAGGGCTTCTCCCTCAAGGGTGGCTCCGAGCACCGCACCTGCAAGGCGGATGGCAGCTGGAC       AGGCAAGCCGCCCATCTGCCTGGCAGAGGTCCGGCCCAGTGGGAGACCCATCAACACTGCCCGGGAGC       CACCGCTCACCCAAGCCT TGA   TTCCTGGGGATGTTTTTGCCAAGAATTCCCTGTGGAAAGGGGCCTAT           GAATACCAGGGGAAGAAGCAGCCAGCCATGCTCAGAGTGACTGGCTTCCAAGTTGCCAACAGCAAGGT           CAATGCCACCATGATCGACCACAGTGGCGTGGAGCTGCACTTGGCTGGAACTTACAAGAAAGAAGATT           TTCATCTCCTACTCCAGGTGTACCAGATTACAGGGCCTGTGGAGATCTTTATGAATAAGTTCAAAGAT           GATCACTGGGCTTTAGATGGCCATGTCTCGTCAGAGTCCTCCGGAGCCACCTTCATCTACCAAGGCTC           TGTCAAGGGCCAAGGCTTTGGGCAGTTCGGCTTTCAAAGACTGGACCTCAGGCTGCTGGAGTCAGACC           CCGAGTCCATTGGCCGCCACTTTGCTTCCAACAGCAGCTCAGTGGCAGCCGCGATCCTGGTGCCTTTC           ATCGCCCTCATTATTGCGGGCTTCGTGCTCTATCTCTACAAGCACAGGAGAAGACCCAAAGTTCCTTT           CAATGGCTATGCTGGCCAcGAGAACACCAATGTTCGGGCCACATTTGAGAACCCAATGTACGACCGCA           ACATCCAGCCCACAGACATCATGGCCAGCGAGGCGGAGTTCACAGTCAGCACAGTGTGCACAGCAGTA           TAGCCACCCGGCCTGGCCGCTTTTTTTGCTAGGTTGAACTGGTACTCCAGCAGCCGCCGAAGCTGGAC           TGTACTGCTGCCATCTCAGCTCACTGCAACCTCCCTGCCTGATTCCCCTGCCTCAGCCTGCCGAGTGC           CTGCGATTGCAGGCGCGCACCGCCACNNT                                           NOV4n, CG50377-10   SEQ ID NO: 58   884 aa   MW at 94718.1kD           Protein Sequence                     MAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFGKEYTVGTKAVYSCSEGYHLQAGAEATAEC           LDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQAN       GKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEV       RCLAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHP       GNPVNGLTQGNQFNLNDVVKFVCNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQV       HASGPHRFSFGTTVSYRCXTTASTSWATPVLSCQGDGTWDRPRPQCLLVSCGHPGSPPHSQMSGDSYT       VGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGTRLGDSFDPGTVMRF       SCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYAT       GLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCT       KDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELP       QCFPVFCGDPGVPSRGRPEDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTC       ADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHA       NVGALDLPSMGYTLITPARRASPSRVAPSTAPARRMAAGQASRPSAWQRSGPVGDPSTLPGSHRSPKP                                     NOV4o, CG50377-11   SEQ ID NO: 59   3896 bp           DNA Sequence   ORF Start: ATG at 427   ORF Stop: TGA at 3073                       GGATTTGAGAGCCTGAACTTAGCCATACACCAGATCTACCTTTGGACCGCAAAAGGGACCCAGTGCTT               CATGAAGCTGGTTTTTTTTGTTTTGTTTTGTTTTTTTTCCGTTGTTTTGTTTCGGCTTTACCAACCTG           ACTGGGTGTTTTTCAATATCCACCATTCAGACTTTCCTCAACAGCAGAGGATGTGGCAGTGGCAAAGA           CAAGGGGATGGGGGGAGACGAAAGGGAAAGGGGCCTGCATGAAAGACCATGTCTGTCTTCCTGCTGGT           GCCAGTTCCCTGAACCTCATCTTGTTGTTCAGCCCCTTACTGCAGCCTGCCCAGGGCTCCACTCCATG           GCTTCATCCTAGGCCAGACCAGCACCCAGCCCGGGGGCTCCATCCACTTTGGCTGCAACGCCGGCTAC           CGCCTGGTGGGACACAGC   ATG GCCATCTGTACCCGGCACCCCCAGGGCTACCACCTGTGGAGCGAAGC       CATCCCTCTCTGTCAAGCTCTTTCCTGTGGGCTTCCTGAGGCCCCCAAGAATGGAATGGTGTTTGGCA       AGGAGTACACAGTGGGAACCAAGGCCGTGTACAGCTGCAGTGAAGGCTACCACCTCCAGGCAGGCGCT       GAGGCCACTGCAGAGTGTCTGGACACAGGCCTATGGAGCAACCGCAATGTCCCACCACAGTGTGTCCC       TGTGACTTGTCCTGATGTCAGTAGCATCAGCGTGGAGCATGGCCGATGGAGGCTTATCTTTGAGACAC       AGTATCAGTTCCAGGCCCAGCTGATGCTCATCTGTGACCCTGGCTACTACTATACTGGCCAAAGGGTC       ATCCGCTGTCAGGCCAATGGCAAATGGAGCCTCGGGGACTCTACGCCCACCTGCCGAATCATCTCCTG       TGGAGAGCTCCCGATTCCCCCCAATGGCCACCGCATCGGAACACTGTCTGTCTACGGGGCAACAGCCA       TCTTCTCCTGCAATTCCGGATACACACTGGTGGGCTCCAGGGTGCGTGAGTGCATGGCCAATGGGCTC       TGGAGTGGCTCTGAAGTCCGCTGCCTTGCTGGACACTGTGGGACTCCTGAGCCCATTGTCAACGGACA       CATCAATGGGGAGAACTACAGCTACCGGGGCAGTGTGGTGTACCAATGCAATGCTGGCTTCCGCCTGA       TCGGCATGTCTGTGCGCATCTGCCAGCAGGATCATCACTGGTCGGGCAAGACCCCTTTCTGTGTGCCA       ATTACCTGTGGACACCCAGGCAACCCTGTCAACGGCCTCACTCAGGGTAACCAGTTTAACCTCAACGA       TGTGGTCAAGTTTGTTTGCAACCCTGGGTATATGGCTGAGGGGGCTGCTAGGTCCCAATGCCTGGCCA       GCGGGCAATGGAGTGACATGCTGCCCACCTGCAGAATCATCAACTGTACAGATCCTGGACACCAAGAA       AATAGTGTTCGTCAGGTCCACGCCAGCGGCCCGCACAGGTTCAGCTTCGGCACCACTGTGTCTTACCG       GTGCAACCACGGCTTCTACCTCCTGGGCACCCCAGTGCTCAGCTGCCAGGGAGATGGCACATGGGACC       GTCCCCGCCCCCAGTGTCTCTTGGTGTCCTGTGGCCATCCGGGCTCCCCGCCTCACTCCCAGATGTCT       GGAGACAGTTATACTGTGGGAGCAGTGGTGCGGTACAGCTGCATCGGCAAGCGTACTCTGGTGGGAAA       CAGCACCCGCATGTGTGGGCTGGATGGACACTGGACTGGCTCCCTCCCTCACTGCTCAGGAACCAGCG       TGGGAGTTTGCGGTGACCCTGGGATCCCGGCTCATGGCATCCGTTTGGGGGACAGCTTTGATCCAGGC       ACTGTGATGCGCTTCAGCTGTGAAGCTGGCCACGTGCTCCGGGGATCGTCAGAGCGCACCTGTCAAGC       CAATGGCTCGTGGAGCGGCTCGCAGCCTGAGTGTGGAGTGATCTCTTGTGGGAACCCTGGGACTCCAA       GTAATGCCCGAGTTGTGTTCAGTGATGGCCTGGTTTTCTCCAGCTCTATCGTCTATGAGTGCCGGGAA       GGATACTACGCCACAGGCCTGCTCAGCCGTCACTGCTCGGTCAATGGTACCTGGACAGGCAGTGACCC       TGAGTGCCTCGTCATAAACTGTGGTGACCCTGGGATTCCAGCCAATGGCCTTCGGCTGGGCAATGACT       TCAGGTACAACAAAACTGTGACATATCAGTGTGTCCCTGGCTATATGATGGAGTCACATAGAGTATCT       GTGCTGAGCTGCACCAAGGACCGGACATGGAATGGAACCAAGCCCGTCTGCAAAGCTCTCATGTGCAA       GCCACCTCCGCTCATCCCCAATGGGAAGGTGGTGGGGTCTGACTTCATGTGGGGCTCAAGTGTGACTT       ATGCCTGCCTGGAGGGGTACCAGCTCTCCCTGCCCGCGGTGTTCACCTGTGAGGGAAATGGGTCCTGG       ACCGGAGAGCTGCCTCAGTGTTTCCCTGTGTTCTGCGGGGATCCTGGTGTCCCGTCCCGTGGGAGGAG       AGAGGACCGAGGCTTCTCCTACAGGTCATCTGTCTCCTTCTCCTGCCATCCCCCTCTGGTGCTGGTGG       GCTCTCCACGCAGGTTTTGCCAGTCAGATGGGACATGGAGTGGCACCCAGCCCAGCTGCATAGATCCG       ACCCTGACCACGTGTGCGGACCCTGGTGTGCCACAGTTTGGGATACAGAACAATTCTCAGGGCTACCA       GGTTGGAAGCACAGTCCTCTTCCGTTGTCAAAAAGGCTACCTGCTTCAGGGCTCCACCACCAGGACCT       GCCTCCCAAACCTGACCTGGAGTGGAACCCCACCTGACTGTGTCCCCCACCACTGCAGGCAGCCAGAG       ACGCCAACGCATGCCAACGTCGGGGCCCTGGATTTGCCCTCCATGGGCTACACGCTCATTACTCCTGC       CAGGAGGGCTTCTCCCTCAAGGGTGGCTCCGAGCACCGCACCTGCAAGGCGGATGGCAGCTGGACAGG       CAAGCCGCCCATCTGCCTGGAGGTCCGGCCCAGTGGGAGACCCATCAACACTGCCCGGGAGCCACCGC       TCACCCAAGCCT TGA   TTCCTGGGGATGTTTTTGCCAAGAATTCCCTGTGGAAAGGGGCCTATGAATAC           CAGGGGAAGAAGCAGCCAGCCATGCTCAGAGTGACTGGCTTCCAAGTTGCCAACAGCAAGGTCAATGC           CACCATGATCGACCACAGTGGCGTGGAGCTGCACTTGGCTGGAACTTACAAGAAAGAAGATTTTCATC           TCCTACTCCAGGTGTACCAGATTACAGGGCCTGTGGAGATCTTTATGAATAAGTTCAAAGATGATCAC           TGGGCTTTAGATGGCCATGTCTCGTCAGAGTCCTCCGGAGCCACCTTCATCTACCAAGGCTCTGTCAA           GGGCCAAGGCTTTGGGCAGTTCGGCTTTCAAAGACTGGACCTCAGGCTGCTGGAGTCAGACCCCGAGT           CCATTGGCCGCCACTTTGCTTCCAACAGCAGCTCAGTGGCAGCCGCGATCCTGGTGCCTTTCATCGCC           CTCATTATTGCGGGCTTCGTGCTCTATCTCTACAAGCACAGGAGAAGACCCAAAGTTCCTTTCAATGG           CTATGCTGGCCACGAGAACACCAATGTTCGGGCCACATTTGAGAACCCAATGTACGACCGCAACATCC           AGCCCACAGACATCATGGCCAGCGAGGCGGAGTTCACAGTCAGCACAGTGTGCACAGCAGTATAGCCA           CCCGGCCTGGCCGCTTTTTTTGCTAGGTTGAACTGGTACTCCAGCAGCCGCCCAAGCTGGACTGTACT           GCTGCCATCTCAGCTCACTGCAACCTCCCTGCCTGATTCCCCTGCCTCAGCCTGCCGAGTGCCTGCGA           TTGCAGGCGCGCACCGCCAC                                       NOV4o, CG50377-11   SEQ ID NO: 60   882 aa MW at 94686.1kD           Protein Sequence                     MAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFGKEYTVGTKAVYSCSEGYHLQAGAEATAEC           LDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQAN       GKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEV       RCLAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHP       GNPVNGLTQGNQFNLNDVVKFVCNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQV       HASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWDRPRPQCLLVSCGHPGSPPHSQMSGDSYTV       GAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGTRLGDSFDPGTVMRFS       CEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATG       LLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTK       DRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQ       CFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCA       DPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHAN       VGALDLPSMGYTLITPARRASPSRVAPSTAPARRMAAGQASRPSAWRSGPVGDPSTLPGSHRSPKP                                     NOV4p, SNP13382457 of   SEQ ID NO: 61   10136 bp           CG50377-01, DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 9313           SNP Pos: 3120   SNP Change: G to A                       ATG GCGGGCGCCCCTCCCCCCGCCTTGCTGCTGCCTTGCAGTTTGATCTCAGACTGCTGTGCTAGCAA           TCAGCGACACTCCGTGGGCGTAGGACCCTCCGAGCTAGTCAAGAAGCAAATTGAGTTGAAGTCTCGAG       GTGTGAAGCTGATGCCCAGCAAAGACAACAGCCAGAAGACGTCTGTGTTAACTCAGGTTGGTGTGTCC       CAAGGACATAATATGTGTCCAGACCCTGGCATACCCGAAAGGGGCAAAAGACTAGGCTCGGATTTCAG       GTTAGGATCCAGCGTCCAGTTCACCTGCAACGAGGGCTATGACCTGCAAGGGTCCAAGCGGATCACCT       GTATGAAAGTGAGCGACATGTTTGCGGCCTGGAGCGACCACAGGCCAGTCTGCCGAGCCCGCATGTGT       GATGCCCACCTTCGAGGCCCCTCGGGCATCATCACCTCCCCCAATTTCCCCATTCAGTATGACAACAA       TGCACACTGTGTGTGGATCATCACAGCACTCAACCCCTCCAAGGTGATCAAGCTCGCCTTTGAGGAGT       TTGATTTGGAGAGGGGCTATGACACCCTGACGGTCGGTGATGGTGGTCAGGATGGGGACCAGAAGACA       GTTCTCTACATGTCTCAAAATGCCTGCAGTGACAGCCCTCACACCCCAGGCTCTCGCATCCCAGAGAG       CATGTCTGGGGACATCTGGAGGCAGAAATGGACTGTACTTGAGATCTGTCGTGACATTAGCAGTTCAG       ATGCAAGGTCAGGTTCAGTGAGGAAGTCTCCAAAGACTTCTAATGCTGTGGAACTTGTTGCTCCTGGG       ACAGAGATCGAGCAGGGCAGTTGCGGTGACCCTGGCATACCTGCATATGGCCGGAGGGAAGGCTCCCG       GTTTCACCACGGTGACACACTCAAGTTTGAGTGCCAGCCCGCCTTTGAGCTGGTGGGACAGAAGGCAA       TCACATGCCAAAAGAATAACCAATGGTCGGCTAAGAAGCCAGGCTGCGTGTTCTCCTGCTTCTTCAAC       TTCACCAGCCCGTCTGGGGTTGTCCTGTCTCCCAACTACCCAGAGGACTATGGCAACCACCTCCACTG       TGTCTGGCTCATCCTGGCCAGGCCTGAGAGCCGCATCCACCTGGCCTTCAACGACATTGACGTGGAGC       CTCAGTTTGATTTCCTGGTCATCAAGGATGGGGCCACCGCCGAGGCGCCCGTCCTGGGCACCTTCTCA       GGAAACCAGCTTCCCTCCTCCATCACAAGCAGTGGCCACGTGGCCCGTCTCGAGTTCCAGACTGACCA       CTCCACAGGGAAGAGGGGCTTCAACATCACTTTTACCACCTTCCGACACAACGAGTGCCCGGATCCTG       GCGTTCCAGTAAATGGCAAACGGTTTGGGGACAGCCTCCAGCTGGGCAGCTCCATCTCCTTCCTCTGT       GATGAAGGCTTCCTTGGGACTCAGGGCTCAGAGACCATCACCTGCGTCCTGAAGGAGGGCAGCGTGGT       CTGGAACAGCGCTGTGCTGCGGTGTGAAGCTCCCTGTGGTGGTCACCTGACTTCGCCCAGCGGCACCA       TCCTCTCTCCGGGCTGGCCTGGCTTCTACAAGGATGCCTTGAGCTGTGCCTGGGTGATTGAGGCCCAG       CCAGGCTACCCCATCAAAATCACCTTCGACAGATTCAAAACCGAGGTCAACTATGACACCCTGGAAGT       ACGCGATGGGCGGACTTACTCAGCGCCCTTGATCGGGGTTTACCACGGGACCCAGGTTCCCCAGTTCC       TCATCAGCACCAGCAACTACCTCTACCTCCTCTTCTCTACCGACAAGAGTCACTCGGACATCGGCTTC       CAGCTCCGCTATGAGACTATAACACTGCAGTCAGACCACTGTCTGGATCCAGGAATCCCAGTAAATGG       ACAGCGTCATGGGAATGACTTCTACGTGGGCGCGCTGGTGACCTTCAGCTGTGACTCGGGCTACACAT       TAAGTGACGGGGAGCCTCTGGAGTGTGAGCCCAACTTCCAGTGGAGCCGGGCCCTGCCCAGTTGTGAA       GCTCTCTGTGGTGGCTTCATTCAAGGCTCCAGTGGGACCATCTTGTCGCCAGGGTTCCCTGACTTCTA       CCCCAACAACTTGAACTGCACCTGGATTATCGAAACATCTCATGGCAAGGGTGTGTTCTTCACTTTCC       ACACCTTCCACCTGGAAAGTGGCCATGACTACCTCCTCATCACTGAGAACGGCAGCTTCACCCAGCCC       CTGAGGCAGCTAACTGGATCTCGGCTGCCAGCTCCCATCAGCGCTGGGCTCTATGGCAACTTCACTGC       CCAGGTCCGCTTCATCTCTGATTTCTCCATGTCATATGAAGGATTCAACATCACCTTCTCAGAGTACG       ACTTGGAGCCCTGTGAGGAGCCCGAGGTCCCAGCCTACAGCATCCGGAAGGGCTTGCAGTTTGGCGTG       GGCGACACCTTGACCTTCTCCTGCTTCCCCGGGTACCGTCTGGAGGGCACCGCCCGCATCACGTGCCT       GGGGGGCAGACGGCGCCTGTGGAGCTCGCCTCTGCCAAGGTGTGTTGCTGAGTGTGGGAATTCAGTCA       CAGGCACTCAGGGTACTTTGCTGTCCCCCAACTTTCCTGTGAACTACAATAACAATCATGAATGCATC       TACTCCATCCAGACCCAGCCAGGGAAGGGAATTCAGCTGAAAGCCAGGGCATTCGAACTCTCCGAAGG       AGATGTCCTCAAGGTTTATGATGGCAACAACAACTCCGCCCGTTTGCTGGGAGTTTTTAGCCATTCTG       AGATGATGGGGGTGACTTTGAACAGCACATCCAGCAGTCTGTGGCTTGATTTCATCACTGATGCTGAA       AACACCAGCAAGGGCTTTGAACTGCACTTTTCCAGCTTTGAACTCATCAAATGTGAGGACCCAGGAAC       CCCCAAGTTTGGCTACAAGGTTCATGATGAAGGTCATTTTGCAGGGAGCTCCGTGTCCTTCAGCTGTG       ACCCTGGATACAGCCTGCGGGGTAGTGAGGAGCTGCTGTGTCTGAGTGGAGAGCGCCGGACCTGGGAC       CGGCCTCTGCCCACCTGTGTCGCCGAGTGTGGAGGGACAGTGAGAGGAGAGGTGTCGGG   A   CAGGTGCT       GTCACCCGGGTATCCAGCTCCCTATGAACACAATCTCAACTGCATCTGGACCATCGAAGCAGAGGCCG       GCTGCACCATTGGGCTACACTTCCTGGTGTTTGACACAGAGGAGGTTCACGACGTGCTGCGCATCTGG       GATGGGCCTGTGGAGAGCGGGGTTCTGCTGAAGGAGCTGAGTGGCCCGGCCCTGCCCAAGGACCTGCA       TAGCACCTTCAACTCGGTCGTCCTGCAGTTCAGCACTGACTTCTTCACCAGCAAGCAGGGCTTTGCCA       TTCAATTTTCAGTGTCCACAGCAACGTCCTGCAATGACCCTGGGATCCCGCAGAATGGGAGTCGGAGT       GGTGACAGTTGGGAAGCCGGCGACTCCACAGTGTTCCAGTGTGACCCTGGCTACGCGCTGCAGGGAAG       TGCAGAGATCAGCTGTGTGAAGATCGAGAACAGGTTCTTCTGGCAGCCCAGCCCGCCAACATGCATCG       CTCCCTGCGGGGGAGACCTGACAGGACCATCTGGAGTCATCCTCTCACCAAATTACCCAGAACCCTAC       CCGCCAGGCAAGGAGTGTGACTGGAAAGTGACCGTCTCACCAGACTACGTCATCGCCCTGGTATTTAA       CATCTTTAACCTGGAGCCTGGCTATGACTTCCTCCATATCTACGACGGACGGGACTCTCTCAGCCCTC       TCATAGGAAGCTTCTATGGCTCCCAGCTCCCAGGCCGCATTGAAAGCAGCAGCAACAGCCTCTTCCTC       GCCTTCCGCAGCGATGCATCTGTGAGCAATGCTGGCTTCGTCATTGACTATACAGAAAACCCGCGGGA       GTCATGTTTTGATCCTGGTTCCATCAAGAACGGCACACGGGTGGGGTCCGACCTGAAGCTGGGCTCCT       CCGTCACCTACTACTGCCACGGGGGCTACGAAGTTGAGGGCACCTCGACCCTGAGCTGCATCCTGGGG       CCTGATGGGAAGCCCGTGTGGAACAATCCCCGGCCAGTCTGCACAGCCCCCTGTGGGGGACAGTATGT       GGGTTCGGACGGAGTGGTCTTGTCCCCCAACTACCCCCAGAACTACACCAGTGGACAGATCTGCTTGT       ATTTTGTTACTGTGCCCAAGGACTATGTGGTGTTTGGCCAGTTCGCCTTCTTTCACACGGCCCTCAAC       GACGTGGTGGAGGTTCACGACGGCCACAGCCAGCACTCGCGGCTCCTCAGCTCCCTCTCGGGCTCCCA       TACAGGAGAATCACTGCCCTTGGCCACCTCCAATCAAGTTCTCATTAAGTTCAGCGCCAAAGGCCTCG       CACCAGCCAGAGGCTTCCACTTTGTCTACCAAGCGGTTCCTCGAACCAGCGCCACGCAGTGCAGCTCT       GTGCCGGAACCCCGCTATGGCAAGAGGCTGGGCAGTGACTTCTCGGTGGGGGCCATCGTCCGCTTCGA       ATGCAACTCCGGCTATGCCCTGCAGGGGTCGCCAGAGATCGAGTGCCTCCCTGTGCCTGGGGCCTTGG       CCCAATGGAATGTCTCAGCGCCCACGTGTGTGGTGCCGTGTGGAGGCAACCTCACAGAGCGCAGGGGC       ACCATCCTGTCCCCTGGCTTCCCAGAGCCGTACCTCAACAGCCTCAACTGTGTGTGGAAGATCGTGGT       CCCCGAAGGCGCTGGCATCCAGATCCAAGTTGTCAGTTTTGTGACAGAGCAGAACTGGGACTCGCTGG       AAGTATTTGATGGTGCAGATAACACTGTAACCATGCTGGGGAGTTTCTCAGGAACAACCGTGCCTGCC       CTTCTGAACAGCACCTCCAACCAGCTCTACCTTCATTTCTACTCAGATATCAGCGTATCTGCAGCTGG       CTTCCACTTGGAGTACAAAACGGTGGGCCTGAGCAGTTGTCCGGAACCTGCTGTGCCCAGTAACGGGG       TGAAGACTGGCGAGCGCTACTTGGTGAATGATGTGGTGTCTTTCCAGTGTGAGCCGGGATATGCCCTC       CAGGGCCACGCCCACATCTCCTGCATGCCCGGAACAGTGCGGCGATGGAACTACCCTCCTCCACTCTG       TATTGCACAGTGTGGGGGAACAGTGGAGGAGATGGAGGGGGTGATCCTGAGCCCCGGCTTCCCAGGCA       ACTACCCCAGTAACATGGACTGCTCCTGGAAAATAGCACTGCCCGTGGGCTTTGGAGCTCACATCCAG       TTCCTGAACTTCTCCACCGAGCCCAACCACGACTACATAGAAATCCGGAATGGCCCCTATGAGACCAG       CCGCATGATGGGAAGATTCAGTGGAAGCGAGCTTCCAAGCTCCCTCCTCTCCACGTCCCACGAGACCA       CCGTGTATTTCCACAGCGACCACTCCCAGAATCGGCCAGGATTCAAGCTGGAGTATCAGGCCTATGAA       CTTCAAGAGTGCCCAGACCCAGAGCCCTTTGCCAATGGCATTGTGAGGGGAGCTGGCTACAACGTGGG       ACAATCAGTGACCTTCGAGTGCCTCCCGGGGTATCAATTGACTGGCCACCCTGTCCTCACGTGTCAAC       ATGGCACCAACCGGAACTGGGACCACCCCCTGCCCAAGTGTGAAGTCCCTTGTGGCGGGAACATCACT       TCTTCCAACGGCACTGTGTACTCCCCGGGGTTCCCTAGCCCGTACTCCAGCTCCCAGGACTGTGTCTG       GCTGATCACCGTGCCCATTGGCCATGGCGTCCGCCTCAACCTCAGCCTGCTGCAGACAGAGCCCTCTG       GAGATTTCATCACCATCTGGGATGGGCCACAGCAAACAGCACCACGGCTCGGCGTCTTCACCCGGAGC       ATGGCCAAGAAAACAGTGCAGAGTTCATCCAACCAGGTCCTGCTCAAGTTCCACCGTGATGCAGCCAC       AGGGGGGATCTTCGCCATAGCTTTCTCCGCTTATCCACTCACCAAATGCCCTCCTCCCACCATCCTCC       CCAACGCCGAAGTCGTCACAGAGAATGAAGAATTCAATATAGGTGACATCGTACGCTACAGATGCCTC       CCTGGCTTTACCTTAGTGGGGAATGAAATTCTGACCTGCAAACTTGGAACCTACCTGCAGTTTGAAGG       ACCACCCCCGATATGTGAAGTGCACTGTCCAACAAATGAGCTTCTGACAGACTCCACAGGCGTGATCC       TGAGCCAGAGCTACCCTGGAAGCTATCCCCAGTTCCAGACCTGCTCTTGGCTGGTGAGAGTGGAGCCC       GACTATAACATCTCCCTCACAGTGGAGTACTTCCTCAGCGAGAAGCAATATGATGAGTTTGAGATTTT       TGATGGTCCATCAGGACAGAGTCCTCTGCTGAAAGCCCTCAGTGGGAATTACTCAGCTCCCCTGATTG       TCACCAGCTCAAGCAACTCTGTGTACCTGCGTTGGTCATCTGATCACGCCTACAATCGGAAGGGCTTC       AAGATCCGCTATTCAGCCCCTTACTGCAGCCTGCCCAGGGCTCCACTCCATGGCTTCATCCTAGGCCA       GACCAGCACCCAGCCCGGGGGCTCCATCCACTTTGGCTGCAACGCCGGCTACCGCCTGGTGGGACACA       GCATGGCCATCTGTACCCGGCACCCCCAGGGCTACCACCTGTGGAGCGAAGCCATCCCTCTCTGTCAA       GCTCTTTCCTGTGGGCTTCCTGAGGCCCCCAAGAATGGAATGGTGTTTGGCAAGGAGTACACAGTGGG       AACCAAGGCCGTGTACAGCTGCAGTGAAGGCTACCACCTCCAGGCAGGCGCTGAGGCCACTGCAGAGT       GTCTGGACACAGGCCTATGGAGCAACCGCAATGTCCCACCACAGTGTGTCCCTGTGACTTGTCCTGAT       GTCAGTAGCATCAGCGTGGAGCATGGCCGATGGAGGCTTATCTTTGAGACACAGTATCAGTTCCAGGC       CCAGCTGATGCTCATCTGTGACCCTGGCTACTACTATACTGGCCAAAGGGTCATCCGCTGTCAGGCCA       ATGGCAAATGGAGCCTCGGGGACTCTACGCCCACCTGCCGAATCATCTCCTGTGGAGAGCTCCCGATT       CCCCCCAATGGCCACCGCATCGGAACACTGTCTGTCTACGGGGCAACAGCCATCTTCTCCTGCAATTC       CGGATACACACTGGTGGGCTCCAGGGTGCGTGAGTGCATGGCCAATGGGCTCTGGAGTGGCTCTGAAG       TCCGCTGCCTTGCTGGACACTGTGGGACTCCTGAGCCCATTGTCAACGGACACATCAATGGGGAGAAC       TACAGCTACCGGGGCAGTGTGGTGTACCAATGCAATGCTGGCTTCCGCCTGATCGGCATGTCTGTGCG       CATCTGCCAGCAGGATCATCACTGGTCGGGCAAGACCCCTTTCTGTGTGCCAATTACCTGTGGACACC       CAGGCAACCCTGTCAACGGCCTCACTCAGGGTAACCAGTTTAACCTCAACGATGTGGTCAAGTTTGTT       TGCAACCCTGGGTATATGGCTGAGGGGGCTGCTAGGTCCCAATGCCTGGCCAGCGGGCAATGGAGTGA       CATGCTGCCCACCTGCAGAATCATCAACTGTACAGATCCTGGACACCAAGAAAATAGTGTTCGTCAGG       TCCACGCCAGCGGCCCGCACAGGTTCAGCTTCGGCACCACTGTGTCTTACCGGTGCAACCACGGCTTC       TACCTCCTGGGCACCCCAGTGCTCAGCTGCCAGGGAGATGGCACATGGGACCGTCCCCGCCCCCAGTG       TCTCTTGGTGTCCTGTGGCCATCCGGGCTCCCCGCCTCACTCCCAGATGTCTGGAGACAGTTATACTG       TGGGAGCAGTGGTGCGGTACAGCTGCATCGGCAAGCGTACTCTGGTGGGAAACAGCACCCGCATGTGT       GGGCTGGATGGACACTGGACTGGCTCCCTCCCTCACTGCTCAGGAACCAGCGTGGGAGTTTGCGGTGA       CCCTGGGATCCCGGCTCATGGCATCCGTTTGGGGGACAGCTTTGATCCAGGCACTGTGATGCGCTTCA       GCTGTGAAGCTGGCCACGTGCTCCGGGGATCGTCAGAGCGCACCTGTCAAGCCAATGGCTCGTGGAGC       GGCTCGCAGCCTGAGTGTGGAGTGATCTCTTGTGGGAACCCTGGGACTCCAAGTAATGCCCGAGTTGT       GTTCAGTGATGGCCTGGTTTTCTCCAGCTCTATCGTCTATGAGTGCCGGGAAGGATACTACGCCACAG       GCCTGCTCAGCCGTCACTGCTCGGTCAATGGTACCTGGACAGGCAGTGACCCTGAGTGCCTCGTCATA       AACTGTGGTGACCCTGGGATTCCAGCCAATGGCCTTCGGCTGGGCAATGACTTCAGGTACAACAAAAC       TGTGACATATCAGTGTGTCCCTGGCTATATGATGGAGTCACATAGAGTATCTGTGCTGAGCTGCACCA       AGGACCGGACATGGAATGGAACCAAGCCCGTCTGCAAAGCTCTCATGTGCAAGCCACCTCCGCTCATC       CCCAATGGGAAGGTGGTGGGGTCTGACTTCATGTGGGGCTCAAGTGTGACTTATGCCTGCCTGGAGGG       GTACCAGCTCTCCCTGCCCGCGGTGTTCACCTGTGAGGGAAATGGGTCCTGGACCGGAGAGCTGCCTC       AGTGTTTCCCTGTGTTCTGCGGGGATCCTGGTGTCCCGTCCCGTGGGAGGAGAGAGGACCGAGGCTTC       TCCTACAGGTCATCTGTCTCCTTCTCCTGCCATCCCCCTCTGGTGCTGGTGGGCTCTCCACGCAGGTT       TTGCCAGTCAGATGGGACATGGAGTGGCACCCAGCCCAGCTGCATAGATCCGACCCTGACCACGTGTG       CGGACCCTGGTGTGCCACAGTTTGGGATACAGAACAATTCTCAGGGCTACCAGGTTGGAAGCACAGTC       CTCTTCCGTTGTCAAAAAGGCTACCTGCTTCAGGGCTCCACCACCAGGACCTGCCTCCCAAACCTGAC       CTGGAGTGGAACCCCACCTGACTGTGTCCCCCACCACTGCAGGCAGCCAGAGACGCCAACGCATGCCA       ACGTCGGGGCCCTGGATTTGCCCTCCATGGGCTACACGCTCATTACTCCTGCCAGGAGGGCTTCTCCC       TCAAGGGTGGCTCCGAGCACCGCACCTGCAAGGCGGATGGCAGCTGGACAGGCAAGCCGCCCATCTGC       CTGGAGGTCCGGCCCAGTGGGAGACCCATCAACACTGCCCGGGAGCCACCGCTCACCCAAGCCT TGA   T           TCCTGGGGATGTTTTTGCCAAGAATTCCCTGTGGAAAGGGGCCTATGAATACCAGGGGAAGAAGCAGC           CAGCCATGCTCAGAGTGACTGGCTTCCAAGTTGCCAACAGCAAGGTCAATGCCACCATGATCGACCAC           AGTGGCGTGGAGCTGCACTTGGCTGGAACTTACAAGAAAGAAGATTTTCATCTCCTACTCCAGGTGTA           CCAGATTACAGGGCCTGTGGAGATCTTTATGAATAAGTTCAAAGATGATCACTGGGCTTTAGATGGCC           ATGTCTCGTCAGAGTCCTCCGGAGCCACCTTCATCTACCAAGGCTCTGTCAAGGGCCAAGGCTTTGGG           CAGTTCGGCTTTCAAAGACTGGACCTCAGGCTGCTGGAGTCAGACCCCGAGTCCATTGGCCGCCACTT           TGCTTCCAACAGCAGCTCAGTGGCAGCCGCGATCCTGGTGCCTTTCATCGCCCTCATTATTGCGGGCT           TCGTGCTCTATCTCTACAAGCACAGGAGAAGACCCAAAGTTCCTTTCAATGGCTATGCTGGCCACGAG           AACACCAATGTTCGGGCCACATTTGAGAACCCAATGTACGACCGCAACATCCAGCCCACAGACATCAT           GGCCAGCGAGGCGGAGTTCACAGTCAGCACAGTGTGCACAGCAGTATAGCCACCCGGCCTGGCCGCTT           TTTTTGCTAGGTTGAACTGGTACTCCAGCAGCCGCCGAAGCTGGACTGTACTGCTGCCATCTCAGCTC           CCAC                                           NOV4p, SNP13382457 of   SEQ ID NO: 62   3104 aa   MW at 336746.3kD           CG50377-01,   SNP Pos: 1040       SNP Change: Gly to Gly       Protein Sequence                     MAGAPPPALLLPCSLISDCCASNQRHSVGVGPSELVKKQIELKSRGVKLMPSKDNSQKTSVLTQVGVS           QGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGyDLQGSKRITCMKVSDMFAAWSDHRPVCRARMC       DAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKT       VLYMSQNACSDSPHTPGSRIPESMSGDIWRQKWTVLEICRDISSSDARSGSVRKSPKTSNAVELVAPG       TEIEQGSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFN       FTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFS       GNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLC       DEGFLGTQGSETITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQ       PGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGF       QLRYETITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCE       ALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITENGSFTQP       LRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQFGV       GDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECI       YSIQTQPGKGIQLKAPAFELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAE       NTSKGFELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWD       RPLPTCVAECGGTVRGEVS   G   QVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIW       DGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRS       GDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGPSGVILSPNYPEPY       PPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFL       AFRSDASVSNAGFVIDYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILG       PDGKPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALN       DVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSS       VPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRG       TILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPA       LLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYAL       QGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQ       FLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQAYE       LQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNIT       SSNGTVYSPGFPSPYSSSQDCVWLITVPIGNGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRS       MAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCL       PGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEP       DYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGF       KIRYSAPYCSLPPAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQ       ALSCGLPEAPKNGMVFGKEYTVGTKAVYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPD       VSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPI       PPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGEN       YSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFV       CNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGF       YLLGTPVLSCQGDGTWDRPRPQCLLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMC       GLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWS       GSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVI       NCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLI       PNGKVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRPEDRGF       SYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTV       LFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGYTLITPARRASP       SRVAPSTAPARPMAAGQASRPSAWRSGPVGDPSTLPGSHRSPKP                                     NOV4q, SNP13382458 of   SEQ ID NO: 63   10136 bp           CG50377-01, DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 9313           SNP Pos: 4429   SNP Change: A to G                       ATG GCGGGCGCCCCTCCCCCCGCCTTGCTGCTGCCTTGCAGTTTGATCTCAGACTGCTGTGCTAGCAA           TCAGCGACACTCCGTGGGCGTAGGACCCTCCGAGCTAGTCAAGAAGCAAATTGAGTTGAAGTCTCGAG       GTGTGAAGCTGATGCCCAGCAAAGACAACAGCCAGAAGACGTCTGTGTTAACTCAGGTTGGTGTGTCC       CAAGGACATAATATGTGTCCAGACCCTGGCATACCCGAAAGGGGCAAAAGACTAGGCTCGGATTTCAG       GTTAGGATCCAGCGTCCAGTTCACCTGCAACGAGGGCTATGACCTGCAAGGGTCCAAGCGGATCACCT       GTATGAAAGTGAGCGACATGTTTGCGGCCTGGAGCGACCACAGGCCAGTCTGCCGAGCCCGCATGTGT       GATGCCCACCTTCGAGGCCCCTCGGGCATCATCACCTCCCCCAATTTCCCCATTCAGTATGACAACAA       TGCACACTGTGTGTGGATCATCACAGCACTCAACCCCTCCAAGGTGATCAAGCTCGCCTTTGAGGAGT       TTGATTTGGAGAGGGGCTATGACACCCTGACGGTCGGTGATGGTGGTCAGGATGGGGACCAGAAGACA       GTTCTCTACATGTCTCAAAATGCCTGCAGTGACAGCCCTCACACCCCAGGCTCTCGCATCCCAGAGAG       CATGTCTGGGGACATCTGGAGGCAGAAATGGACTGTACTTGAGATCTGTCGTGACATTAGCAGTTCAG       ATGCAAGGTCAGGTTCAGTGAGGAAGTCTCCAAAGACTTCTAATGCTGTGGAACTTGTTGCTCCTGGG       ACAGAGATCGAGCAGGGCAGTTGCGGTGACCCTGGCATACCTGCATATGGCCGGAGGGAAGGCTCCCG       GTTTCACCACGGTGACACACTCAAGTTTGAGTGCCAGCCCGCCTTTGAGCTGGTGGGACAGAAGGCAA       TCACATGCCAAAAGAATAACCAATGGTCGGCTAAGAAGCCAGGCTGCGTGTTCTCCTGCTTCTTCAAC       TTCACCAGCCCGTCTGGGGTTGTCCTGTCTCCCAACTACCCAGAGGACTATGGCAACCACCTCCACTG       TGTCTGGCTCATCCTGGCCAGGCCTGAGAGCCGCATCCACCTGGCCTTCAACGACATTGACGTGGAGC       CTCAGTTTGATTTCCTGGTCATCAAGGATGGGGCCACCGCCGAGGCGCCCGTCCTGGGCACCTTCTCA       GGAAACCAGCTTCCCTCCTCCATCACAAGCAGTGGCCACGTGGCCCGTCTCGAGTTCCAGACTGACCA       CTCCACAGGGAAGAGGGGCTTCAACATCACTTTTACCACCTTCCGACACAACGAGTGCCCGGATCCTG       GCGTTCCAGTAAATGGCAAACGGTTTGGGGACAGCCTCCAGCTGGGCAGCTCCATCTCCTTCCTCTGT       GATGAAGGCTTCCTTGGGACTCAGGGCTCAGAGACCATCACCTGCGTCCTGAAGGAGGGCAGCGTGGT       CTGGAACAGCGCTGTGCTGCGGTGTGAAGCTCCCTGTGGTGGTCACCTGACTTCGCCCAGCGGCACCA       TCCTCTCTCCGGGCTGGCCTGGCTTCTACAAGGATGCCTTGAGCTGTGCCTGGGTGATTGAGGCCCAG       CCAGGCTACCCCATCAAAATCACCTTCGACAGATTCAAAACCGAGGTCAACTATGACACCCTGGAAGT       ACGCGATGGGCGGACTTACTCAGCGCCCTTGATCGGGGTTTACCACGGGACCCAGGTTCCCCAGTTCC       TCATCAGCACCAGCAACTACCTCTACCTCCTCTTCTCTACCGACAAGAGTCACTCGGACATCGGCTTC       CAGCTCCGCTATGAGACTATAACACTGCAGTCAGACCACTGTCTGGATCCAGGAATCCCAGTAAATGG       ACAGCGTCATGGGAATGACTTCTACGTGGGCGCGCTGGTGACCTTCAGCTGTGACTCGGGCTACACAT       TAAGTGACGGGGAGCCTCTGGAGTGTGAGCCCAACTTCCAGTGGAGCCGGGCCCTGCCCAGTTGTGAA       GCTCTCTGTGGTGGCTTCATTCAAGGCTCCAGTGGGACCATCTTGTCGCCAGGGTTCCCTGACTTCTA       CCCCAACAACTTGAACTGCACCTGGATTATCGAAACATCTCATGGCAAGGGTGTGTTCTTCACTTTCC       ACACCTTCCACCTGGAAAGTGGCCATGACTACCTCCTCATCACTGAGAACGGCAGCTTCACCCAGCCC       CTGAGGCAGCTAACTGGATCTCGGCTGCCAGCTCCCATCAGCGCTGGGCTCTATGGCAACTTCACTGC       CCAGGTCCGCTTCATCTCTGATTTCTCCATGTCATATGAAGGATTCAACATCACCTTCTCAGAGTACG       ACTTGGAGCCCTGTGAGGAGCCCGAGGTCCCAGCCTACAGCATCCGGAAGGGCTTGCAGTTTGGCGTG       GGCGACACCTTGACCTTCTCCTGCTTCCCCGGGTACCGTCTGGAGGGCACCGCCCGCATCACGTGCCT       GGGGGGCAGACGGCGCCTGTGGAGCTCGCCTCTGCCAAGGTGTGTTGCTGAGTGTGGGAATTCAGTCA       CAGGCACTCAGGGTACTTTGCTGTCCCCCAACTTTCCTGTGAACTACAATAACAATCATGAATGCATC       TACTCCATCCAGACCCAGCCAGGGAAGGGAATTCAGCTGAAAGCCAGGGCATTCGAACTCTCCGAAGG       AGATGTCCTCAAGGTTTATGATGGCAACAACAACTCCGCCCGTTTGCTGGGAGTTTTTAGCCATTCTG       AGATGATGGGGGTGACTTTGAACAGCACATCCAGCAGTCTGTGGCTTGATTTCATCACTGATGCTGAA       AACACCAGCAAGGGCTTTGAACTGCACTTTTCCAGCTTTGAACTCATCAAATGTGAGGACCCAGGAAC       CCCCAAGTTTGGCTACAAGGTTCATGATGAAGGTCATTTTGCAGGGAGCTCCGTGTCCTTCAGCTGTG       ACCCTGGATACAGCCTGCGGGGTAGTGAGGAGCTGCTGTGTCTGAGTGGAGAGCGCCGGACCTGGGAC       CGGCCTCTGCCCACCTGTGTCGCCGAGTGTGGAGGGACAGTGAGAGGAGAGGTGTCGGGGCAGGTGCT       GTCACCCGGGTATCCAGCTCCCTATGAACACAATCTCAACTGCATCTGGACCATCGAAGCAGAGGCCG       GCTGCACCATTGGGCTACACTTCCTGGTGTTTGACACAGAGGAGGTTCACGACGTGCTGCGCATCTGG       GATGGGCCTGTGGAGAGCGGGGTTCTGCTGAAGGAGCTGAGTGGCCCGGCCCTGCCCAAGGACCTGCA       TAGCACCTTCAACTCGGTCGTCCTGCAGTTCAGCACTGACTTCTTCACCAGCAAGCAGGGCTTTGCCA       TTCAATTTTCAGTGTCCACAGCAACGTCCTGCAATGACCCTGGGATCCCGCAGAATGGGAGTCGGAGT       GGTGACAGTTGGGAAGCCGGCGACTCCACAGTGTTCCAGTGTGACCCTGGCTACGCGCTGCAGGGAAG       TGCAGAGATCAGCTGTGTGAAGATCGAGAACAGGTTCTTCTGGCAGCCCAGCCCGCCAACATGCATCG       CTCCCTGCGGGGGAGACCTGACAGGACCATCTGGAGTCATCCTCTCACCAAATTACCCAGAACCCTAC       CCGCCAGGCAAGGAGTGTGACTGGAAAGTGACCGTCTCACCAGACTACGTCATCGCCCTGGTATTTAA       CATCTTTAACCTGGAGCCTGGCTATGACTTCCTCCATATCTACGACGGACGGGACTCTCTCAGCCCTC       TCATAGGAAGCTTCTATGGCTCCCAGCTCCCAGGCCGCATTGAAAGCAGCAGCAACAGCCTCTTCCTC       GCCTTCCGCAGCGATGCATCTGTGAGCAATGCTGGCTTCGTCATTGACTATACAGAAAACCCGCGGGA       GTCATGTTTTGATCCTGGTTCCATCAAGAACGGCACACGGGTGGGGTCCGACCTGAAGCTGGGCTCCT       CCGTCACCTACTACTGCCACGGGGGCTACGAAGTTGAGGGCACCTCGACCCTGAGCTGCATCCTGGGG       CCTGATGGGAAGCCCGTGTGGAACAATCCCCGGCCAGTCTGCACAGCCCCCTGTGGGGGACAGTATGT       GGGTTCGGACGGAGTGGTCTTGTCCCCCAACTACCCCCAGAACTACACCAGTGGACAGATCTGCTTGT       ATTTTGTTACTGTGCCCAAGGACTATGTGGTGTTTGGCCAGTTCGCCTTCTTTCACACGGCCCTCCCA       GACGTGGTGGAGGTTCACGACGGCCACAGCCAGCACTCGCGGCTCCTCAGCTCCCTCTCGGGCTCCCA       TACAGGAGAATCACTGCCCTTGGCCACCTCCAATCAAGTTCTCATTAAGTTCAGCGCCAAAGGCCTCG       CACCAGCC   G   GAGGCTTCCACTTTGTCTACCAAGCGGTTCCTCGAACCAGCGCCACGCAGTGCAGCTCT       GTGCCGGAACCCCGCTATGGCAAGAGGCTGGGCAGTGACTTCTCGGTGGGGGCCATCGTCCGCTTCGA       ATGCAACTCCGGCTATGCCCTGCAGGGGTCGCCAGAGATCGAGTGCCTCCCTGTGCCTGGGGCCTTGG       CCCAATGGAATGTCTCAGCGCCCACGTGTGTGGTGCCGTGTGGAGGCAACCTCACAGAGCGCAGGGGC       ACCATCCTGTCCCCTGGCTTCCCAGAGCCGTACCTCAACAGCCTCAACTGTGTGTGGAAGATCGTGGT       CCCCGAAGGCGCTGGCATCCAGATCCAAGTTGTCAGTTTTGTGACAGAGCAGAACTGGGACTCGCTGG       AAGTATTTGATGGTGCAGATAACACTGTAACCATGCTGGGGAGTTTCTCAGGAACAACCGTGCCTGCC       CTTCTGAACAGCACCTCCAACCAGCTCTACCTTCATTTCTACTCAGATATCAGCGTATCTGCAGCTGG       CTTCCACTTGGAGTACAAAACGGTGGGCCTGAGCAGTTGTCCGGAACCTGCTGTGCCCAGTAACGGGG       TGAAGACTGGCGAGCGCTACTTGGTGAATGATGTGGTGTCTTTCCAGTGTGAGCCGGGATATGCCCTC       CAGGGCCACGCCCACATCTCCTGCATGCCCGGAACAGTGCGGCGATGGAACTACCCTCCTCCACTCTG       TATTGCACAGTGTGGGGGAACAGTGGAGGAGATGGAGGGGGTGATCCTGAGCCCCGGCTTCCCAGGCA       ACTACCCCAGTAACATGGACTGCTCCTGGAAAATAGCACTGCCCGTGGGCTTTGGAGCTCACATCCAG       TTCCTGAACTTCTCCACCGAGCCCAACCACGACTACATAGAAATCCGGAATGGCCCCTATGAGACCAG       CCGCATGATGGGAAGATTCAGTGGAAGCGAGCTTCCAAGCTCCCTCCTCTCCACGTCCCACGAGACCA       CCGTGTATTTCCACAGCGACCACTCCCAGAATCGGCCAGGATTCAAGCTGGAGTATCAGGCCTATGAA       CTTCAAGAGTGCCCAGACCCAGAGCCCTTTGCCAATGGCATTGTGAGGGGAGCTGGCTACAACGTGGG       ACAATCAGTGACCTTCGAGTGCCTCCCGGGGTATCAATTGACTGGCCACCCTGTCCTCACGTGTCAAC       ATGGCACCAACCGGAACTGGGACCACCCCCTGCCCAAGTGTGAAGTCCCTTGTGGCGGGAACATCACT       TCTTCCAACGGCACTGTGTACTCCCCGGGGTTCCCTAGCCCGTACTCCAGCTCCCAGGACTGTGTCTG       GCTGATCACCGTGCCCATTGGCCATGGCGTCCGCCTCAACCTCAGCCTGCTGCAGACAGAGCCCTCTG       GAGATTTCATCACCATCTGGGATGGGCCACAGCAAACAGCACCACGGCTCGGCGTCTTCACCCGGAGC       ATGGCCAAGAAAACAGTGCAGAGTTCATCCAACCAGGTCCTGCTCAAGTTCCACCGTGATGCAGCCAC       AGGGGGGATCTTCGCCATAGCTTTCTCCGCTTATCCACTCACCAAATGCCCTCCTCCCACCATCCTCC       CCAACGCCGAAGTCGTCACAGAGAATGAAGAATTCAATATAGGTGACATCGTACGCTACAGATGCCTC       CCTGGCTTTACCTTAGTGGGGAATGAAATTCTGACCTGCAAACTTGGAACCTACCTGCAGTTTGAAGG       ACCACCCCCGATATGTGAAGTGCACTGTCCAACAAATGAGCTTCTGACAGACTCCACAGAGGTGATCC       TGAGCCAGAGCTACCCTGGAAGCTATCCCCAGTTCCAGACCTGCTCTTGGCTGGTGAGAGTGGAGCCC       GACTATAACATCTCCCTCACAGTGGAGTACTTCCTCAGCGAGAAGCAATATGATGAGTTTGAGATTTT       TGATGGTCCATCAGGACAGAGTCCTCTGCTGAAAGCCCTCAGTGGGAATTACTCAGCTCCCCTGATTG       TCACCAGCTCAAGCAACTCTGTGTACCTGCGTTGGTCATCTGATCACGCCTACAATCGGAAGGGCTTC       AAGATCCGCTATTCAGCCCCTTACTGCAGCCTGCCCAGGGCTCCACTCCATGGCTTCATCCTAGGCCA       GACCAGCACCCAGCCCGGGGGCTCCATCCACTTTGGCTGCAACGCCGGCTACCGCCTGGTGGGACACA       GCATGGCCATCTGTACCCGGCACCCCCAGGGCTACCACCTGTGGAGCGAAGCCATCCCTCTCTGTCAA       GCTCTTTCCTGTGGGCTTCCTGAGGCCCCCAAGAATGGAATGGTGTTTGGCAAGGAGTACACAGTGGG       AACCAAGGCCGTGTACAGCTGCAGTGAAGGCTACCACCTCCAGGCAGGCGCTGAGGCCACTGCAGAGT       GTCTGGACACAGGCCTATGGAGCAACCGCAATGTCCCACCACAGTGTGTCCCTGTGACTTGTCCTGAT       GTCAGTAGCATCAGCGTGGAGCATGGCCGATGGAGGCTTATCTTTGAGACACAGTATCAGTTCCAGGC       CCAGCTGATGCTCATCTGTGACCCTGGCTACTACTATACTGGCCAAAGGGTCATCCGCTGTCAGGCCA       ATGGCAAATGGAGCCTCGGGGACTCTACGCCCACCTGCCGAATCATCTCCTGTGGAGAGCTCCCGATT       CCCCCCAATGGCCACCGCATCGGAACACTGTCTGTCTACGGGGCAACAGCCATCTTCTCCTGCAATTC       CGGATACACACTGGTGGGCTCCAGGGTGCGTGAGTGCATGGCCAATGGGCTCTGGAGTGGCTCTGAAG       TCCGCTGCCTTGCTGGACACTGTGGGACTCCTGAGCCCATTGTCAACGGACACATCAATGGGGAGAAC       TACAGCTACCGGGGCAGTGTGGTGTACCAATGCAATGCTGGCTTCCGCCTGATCGGCATGTCTGTGCG       CATCTGCCAGCAGGATCATCACTGGTCGGGCAAGACCCCTTTCTGTGTGCCAATTACCTGTGGACACC       CAGGCAACCCTGTCAACGGCCTCACTCAGGGTAACCAGTTTAACCTCAACGATGTGGTCAAGTTTGTT       TGCAACCCTGGGTATATGGCTGAGGGGGCTGCTAGGTCCCAATGCCTGGCCAGCGGGCAATGGAGTGA       CATGCTGCCCACCTGCAGAATCATCAACTGTACAGATCCTGGACACCAAGAAAATAGTGTTCGTCAGG       TCCACGCCAGCGGCCCGCACAGGTTCAGCTTCGGCACCACTGTGTCTTACCGGTGCAACCACGGCTTC       TACCTCCTGGGCACCCCAGTGCTCAGCTGCCAGGGAGATGGCACATGGGACCGTCCCCGCCCCCAGTG       TCTCTTGGTGTCCTGTGGCCATCCGGGCTCCCCGCCTCACTCCCAGATGTCTGGAGACAGTTATACTG       TGGGAGCAGTGGTGCGGTACAGCTGCATCGGCAAGCGTACTCTGGTGGGAAACAGCACCCGCATGTGT       GGGCTGGATGGACACTGGACTGGCTCCCTCCCTCACTGCTCAGGAACCAGCGTGGGAGTTTGCGGTGA       CCCTGGGATCCCGGCTCATGGCATCCGTTTGGGGGACAGCTTTGATCCAGGCACTGTGATGCGCTTCA       GCTGTGAAGCTGGCCACGTGCTCCGGGGATCGTCAGAGCGCACCTGTCAAGCCAATGGCTCGTGGAGC       GGCTCGCAGCCTGAGTGTGGAGTGATCTCTTGTGGGAACCCTGGGACTCCAAGTAATGCCCGAGTTGT       GTTCAGTGATGGCCTGGTTTTCTCCAGCTCTATCGTCTATGAGTGCCGGGAAGGATACTACGCCACAG       GCCTGCTCAGCCGTCACTGCTCGGTCAATGGTACCTGGACAGGCAGTGACCCTGAGTGCCTCGTCATA       AACTGTGGTGACCCTGGGATTCCAGCCAATGGCCTTCGGCTGGGCAATGACTTCAGGTACAACAAAAC       TGTGACATATCAGTGTGTCCCTGGCTATATGATGGAGTCACATAGAGTATCTGTGCTGAGCTGCACCA       AGGACCGGACATGGAATGGAACCAAGCCCGTCTGCAAAGCTCTCATGTGCAAGCCACCTCCGCTCATC       CCCAATGGGAAGGTGGTGGGGTCTGACTTCATGTGGGGCTCAAGTGTGACTTATGCCTGCCTGGAGGG       GTACCAGCTCTCCCTGCCCGCGGTGTTCACCTGTGAGGGAAATGGGTCCTGGACCGGAGAGCTGCCTC       AGTGTTTCCCTGTGTTCTGCGGGGATCCTGGTGTCCCGTCCCGTGGGAGGAGAGAGGACCGAGGCTTC       TCCTACAGGTCATCTGTCTCCTTCTCCTGCCATCCCCCTCTGGTGCTGGTGGGCTCTCCACGCAGGTT       TTGCCAGTCAGATGGGACATGGAGTGGCACCCAGCCCAGCTGCATAGATCCGACCCTGACCACGTGTG       CGGACCCTGGTGTGCCACAGTTTGGGATACAGAACAATTCTCAGGGCTACCAGGTTGGAAGCACAGTC       CTCTTCCGTTGTCAAAAAGGCTACCTGCTTCAGGGCTCCACCACCAGGACCTGCCTCCCAAACCTGAC       CTGGAGTGGAACCCCACCTGACTGTGTCCCCCACCACTGCAGGCAGCCAGAGACGCCAACGCATGCCA       ACGTCGGGGCCCTGGATTTGCCCTCCATGGGCTACACGCTCATTACTCCTGCCAGGAGGGCTTCTCCC       TCAAGGGTGGCTCCGAGCACCGCACCTGCAAGGCGGATGGCAGCTGGACAGGCAAGCCGCCCATCTGC       CTGGAGGTCCGGCCCAGTGGGAGACCCATCAACACTGCCCGGGAGCCACCGCTCACCCAAGCCT TGA   T           TCCTGGGGATGTTTTTGCCAAGAATTCCCTGTGGAAAGGGGCCTATGAATACCAGGGGAAGAAGCAGC           CAGCCATGCTCAGAGTGACTGGCTTCCAAGTTGCCAACAGCAAGGTCAATGCCACCATGATCGACCAC           AGTGGCGTGGAGCTGCACTTGGCTGGAACTTACAAGAAAGAAGATTTTCATCTCCTACTCCAGGTGTA           CCAGATTACAGGGCCTGTGGAGATCTTTATGAATAAGTTCAAAGATGATCACTGGGCTTTAGATGGCC           ATGTCTCGTCAGAGTCCTCCGGAGCCACCTTCATCTACCAAGGCTCTGTCAAGGGCCAAGGCTTTGGG           CAGTTCGGCTTTCAAAGACTGGACCTCAGGCTGCTGGAGTCAGACCCCGAGTCCATTGGCCGCCACTT           TGCTTCCAACAGCAGCTCAGTGGCAGCCGCGATCCTGGTGCCTTTCATCGCCCTCATTATTGCGGGCT           TCGTGCTCTATCTCTACAAGCACAGGAGAAGACCCAAAGTTCCTTTCAATGGCTATGCTGGCCACGAG           AACACCAATGTTCGGGCCACATTTGAGAACCCAATGTACGACCGCAACATCCAGCCCACAGACATCAT           GGCCAGCGAGGCGGAGTTCACAGTCAGCACAGTGTGCACAGCAGTATAGCCACCCGGCCTGGCCGCTT           TTTTTGCTAGGTTGAACTGGTACTCCAGCAGCCGCCGAAGCTGGACTGTACTGCTGCCATCTCAGCTC           ACTGCAACCTCCCTGCCTGATTCCCCTGCCTCAGCCTGCCGAGTGCCTGCGATTGCAGGCGCGCACCG           CCAC                                           NOV4q, SNP1 3382458 of   SEQ ID NO: 64   3104 aa   MW at 336647.2kD           CG50377-01,   SNP Pos: 1477   SNP Change: Arg to Gly       Protein Sequence                     MAGAPPPALLLPCSLISDCCASNQRHSVGVGPSELVKKQIELKSRGVKLMPSKDNSQKTSVLTQVGVS           QGHNNCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMC       DAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKT       VLYMSQNACSDSPHTPGSRIPESMSGDIWRQKWTVLEICRDISSSDARSGSVRKSPKTSNAVELVAPG       TEIEQGSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFN       FTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFS       GNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLC       DEGFLGTQGSETITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQ       PGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGF       QLRYETITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCE       ALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITENGSFTQP       LRQLTGSRLPAPISAGLYGNFTAQVRPISDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQFGV       GDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECI       YSIQTQPGKGIQLKARAFELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAE       NTSKGFELHFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWD       RPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIW       DGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRS       GDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGPSGVILSPNYPEPY       PPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFL       AFRSDASVSNAGFVIDYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILG       PDGKPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALN       DVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPA   G   GFHFVYQAVPRTSATQCSS       VPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRG       TILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPA       LLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYAL       QGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQ       FLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQAYE       LQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNIT       SSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRS       MAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCL       PGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEP       DYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGF       KIRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQ       ALSCGLPEAPKNGMVFGKEYTVGTKAVYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPD       VSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPI       PPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGEN       YSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFV       CNPGYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGF       YLLGTPVLSCQGDGTWDRPRPQCLLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTPMC       GLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWS       GSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVI       NCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLI       PNGKVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGF       SYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTV       LFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGYTLITPARRASP       SRVAPSTAPARRMAAGQASRPSAWRSGPVGDPSTLPGSHRSPKP                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 4B.  
                   TABLE 4B                       Comparison of the NOV4 protein sequences.                                            NOV4a   ------------------------------------------------------------           NOV4b   MAGAPPPALLLPCSLISDCCASNQRHSVGVGPSELVKKQIELKSRGVKLMPSKDNSQKTS       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   ------------------------------------------------------------       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   ------------------------------------------------------------       NOV4b   VLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDM       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   ------------------------------------------------------------       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   ------------------------------------------------------------       NOV4b   FAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFE       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   ------------------------------------------------------------       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   ------------------------------------------------------------       NOV4b   EFDLERGYDTLTVGDGGQDGDQKTVLYMSQNACSDSPHTPGSRIPESMSGDIWRQKWTVL       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   ------------------------------------------------------------       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   ------------------------------------------------------------       NOV4b   EICRDISSSDARSGSVRKSPKTSNAVELVAPGTEIEQGSCGDPGIPAYGRREGSRFHHGD       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   ------------------------------------------------------------       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   -------------------------------GQNCTFQLHGPNGTVESPGFPYGYPNYAN       NOV4b   TLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNH       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   -------------------------------GQNCTFQLHGPNGTVESPGFPYGYPNYAN       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   CTWTITAEEQHRIQLVFQSFALEEDFDVLSVFDGPPQPENLRTRLTGFQLPATIVSAATT       NOV4b   LHCVWLILARPESRIHLAFNDIDVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSG       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   CTWTITAEEQHRIQLVFQSFALEEDFDVLSVFDGPPQPENLRTRLTGFQLPATIVSAATT       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   LSLPLISDYAVSAQGFHATYEVLPSHTCGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFL       NOV4b   NVARLEFQTDHSTGKRGFNITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLCDEGF       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   LSLRLISDYAVSAQGFHATYEVLPSHTCGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFL       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   EGHAVLTCHAGSENSATWDFPLPSCRADDACGGTLRGQSGIISSPHFPSEYHNNADCTWT       NOV4b   LGTQGSETITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWV       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   EGHAVLTCHAGSENSATWDFPLPSCRADDACGGTLRGQSGIISSPHFPSEYHNNADCTWT       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   ILAELGDTIALVFIDFQLEDGYDFLEVTGTEGSSLWFTGASLPAPVISSKNWLRLHFTSD       NOV4b   IEAQPGYPIKITFDRFKTEVNYDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLL       NOV4c   --------------------------------------MAGAPPPALLLPCSLISDCCAS       NOV4d   --------------------------------------MAGAPPPALLLPCSLISDCCAS       NOV4e   ILAELGDTIALVFIDFQLEDGYDFLEVTGTEGSSLWFTGASLPAPVISSKNWLRLHFTSD       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   GNHRQRGFSAQYQVKKQIELKSRGVKLMPSKDNSQKTSVVTQVGVSQGHNMCPDPGIPER       NOV4b   FSTDKSHSDIGFQLRYETITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSD       NOV4c   NQRHSVGVGPSELVKKQIELKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPER       NOV4d   NQRHSVGVGPSELVKKQIELKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPER       NOV4e   GNHRQRGFSAQYQVKKQIELKSRGVKLMPSKDNSQKTSVVTQVGVSQGHNMCPDPGIPER       NOV4f   ---------------------------MPSKDNSQKTSVVTQVGVSQGHNMCPDPGIPER       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   GKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRAPMCDAHLRC       NOV4b   GEPLECEPNFQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKG       NOV4c   GKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRG       NOV4d   GKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRG       NOV4e   GKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRAPMCDAHLRG       N0V4f   GKRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRAENCDAHLRG       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   PSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQ       NOV4b   VFFTFHTFHLESGHDYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFS       NOV4c   PSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQ       NOV4d   PSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQ       NOV4e   PSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQ       NOV4f   PSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQ       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   KTVLYMLTGTSVPDLIVSTNHQMWLLFQTDG---------------------SG------       NOV4b   MSYEGFNITFSEYDLEPCEEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLG       NOV4c   KTVLYMSQNACSDSPHTPGSRIPESMSGDIWRQKWTVLEICRDISSSDARSGSVRKSPKT       NOV4d   KTVLYMSQNACSDSPHTPGSRIPESMSGDIWRQKWTVLEICRDISSSDARSGSVRKSPKT       NOV4e   KTVLYMLTGTSVPDLIVSTNHQMWLLFQTDG----------------------------S       NOV4f   KTVLYMLTGTSVPDLIVSTNHQMWLLFQTDG----------------------S------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   -SSLGFKASYEEIEQGSCGDPGIPAYGRREGSRFRHGDTLKFECQPAFELVGQKAITCQK       NOV4b   GRRPLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKAR       NOV4c   SNAVELVAPGTEIEQGSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQK       NOV4d   SNAVELVAPGTEIEQGSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQK       NOV4e   GSSLGFKASYEEIEQGSCGDPGIPAYGRREGSRFRHGDTLKFECQPAFELVGQKAITCQK       NOV4f   GSSLGFKASYEEIEQGSCGDPGIPAYGRREGSRFRHGDTLKFECQPAFELVGQKAITCQK       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   NNQWSAKKPGCVCSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDI       NOV4b   AFELSEGDVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFEL       NOV4c   NNQWSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDI       NOV4d   NNQWSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDI       NOV4e   NNQWSAKKPGCVCSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDI       NOV4f   NNQWSAKKPGCVCSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDI       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   DVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITF       NOV4b   HFSSFELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWD       NOV4c   DVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITF       NOV4d   DVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITF       NOV4e   DVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHvARLEFQTDHSTGKRGFNITF       NOV4f   DVEPQFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITF       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   TSESSNECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNS       NOV4b   RPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEE       NOV4c   TTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNS       NOV4d   TTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNS       NOV4e   TSESSNECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNS       NOV4f   TSESSNECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNS       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   AVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNY       NOV4b   VHDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVST       NOV4c   AVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNY       NOV4d   AVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNY       NOV4e   AVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNY       NOV4f   AVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNY       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   DTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYEAITLQ       NOV4b   ATSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTC       NOV4c   DTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQ       NOV4d   DTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQ       NOV4e   DTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYEAITLQ       NOV4f   DTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYEAITLQ       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   SDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEAL       NOV4b   IAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHI       NOV4c   SDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEAL       NOV4d   SDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEAL       NOV4e   SDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEAL       NOV4f   SDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEAL       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   CGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITEN       NOV4b   YDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDYTENPRESCFDP       NOV4c   CGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITEN       NOV4d   CGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITEN       NOV4e   CGGFIQGSSGTILSPGFPDFYPNNLNCTWITETSHGKGVFFTFHTFHLESGHDYLLITEN       NOV4f   CGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITEN       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   GSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEPE       NOV4b   GSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCGG       NOV4c   GSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEPE       NOV4d   GSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEPE       NOV4e   GSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEPE       NOV4f   GSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEPE       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   VPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGPRRLWSSPLPRCVAECGNSVT       NOV4b   QYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEVHDGHSQH       NOV4c   VPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVT       NOV4d   VPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVT       NOV4e   VPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVT       NOV4f   VPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVT       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   GTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGDVLKVYDGNNNSARL       NOV4b   SRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSVPEP       NOV4c   GTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGDVLKVYDGNNNSARL       NOV4d   GTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGDVLKVYDGNNNSARL       NOV4e   GTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGDVLKVYDGNNNSARL       NOV4f   GTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGDVLKVYDGNNNSARL       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   LGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELIKCEDPGTPKFGYKV       NOV4b   RYGKRLGSDFSVGATVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLT       NOV4c   LGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELIKCEDPGTPKFGYKV       NOV4d   LGVFSHSEMNGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELIKCEDPGTPKFGYKV       NOV4e   LGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELIKCEDPGTPKFGYKV       NOV4f   LGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELIKCEDPGTPKFGYKV       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   HDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAECGGTVRGEVSGQV       NOV4b   ERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVT       NOV4c   HDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAECGGTVRGEVSGQV       NOV4d   HDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAECGGTVRGEVSGQV       NOV4e   HDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAECGGTVRGEVSGQV       NOV4f   HDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAECGGTVRGEVSGQV       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   LSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGPVESGVLLKELS       NOV4b   MLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKT       NOV4c   LSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGPVESGVLLKELS       NOV4d   LSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGPVESGVLLKELS       NOV4e   LSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGPVESGVLLKELS       NOV4f   LSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGPVESGVLLKELS       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   GPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSGSTATSCNDPGIPQNGSRSGDSWEA       NOV4b   GERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVILS       NOV4c   GPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRSGDSWEA       N0V4d   GPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRSGDSWEA       NOV4e   GPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSGSTATSCNDPGIPQNGSRSGDSWEA       NOV4f   GPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSGSTATSCNDPGIPQNGSRSGDSWEA       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   GDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGPSGVILSPNYPE       NOV4b   PGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGPYETSRMMGRFSGS       NOV4c   GDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGPSGVILSPNYPE       NOV4d   GDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGPSGVILSPNYPE       NOV4e   GDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGPSGVILSPNYPE       NOV4f   GDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGGDLTGPSGVILSPNYPE       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   PYPPGKECDWKVTVSPDYVIALVLFPSFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPG       NOV4b   ELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQAYELQECPDPEPFANGIVRGAGYNVGQ       NOV4c   PYPPGKECDWKVTVSPDYVIALVFN-IFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPG       NOV4d   PYPPGKECDWKVTVSPDYVIALVFN-IFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPG       NOV4e   PYPPGKECDWKVTVSPDYVIALVLFPSFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPG       NOV4f   PYPPGKECDWKVTVSPDYVIALVLFPSFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPG       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   RIESSSNSLFLAFRSDASVSNAGFVIDFPENPRESCFDPGSIKNGTRVGSDLKLGSSVTY       NOV4b   SVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSNGTVYSPGFPSPYS       NOV4c   RIESSSNSLFLAFRSDASVSNAGFVIDYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTY       NOV4d   RIESSSNSLFLAFRSDASVSNAGFVIDYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTY       NOV4e   RIESSSNSLFLAFRSDASVSNAGFVIDFPENPRESCFDPGSIKNGTRVGSDLKLGSSVTY       NOV4f   RIESSSNSLFLAFRSDASVSNAGFVIDFPENPRESCFDPGSIKNGTRVGSDLKLGSSVTY       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   --------------------------------KLSCFDPGSIKNGTRVGSDLKLGSSVTY       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   YCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSG       NOV4b   SSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQS       NOV4c   YCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSG       NOV4d   YCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSG       NOV4e   YCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSG       NOV4f   YCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSG       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   YCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCGGQYVGSDGVVLSPNYPQNYTSG       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   QICLYFVTVPKDYGVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSGSHTG-ESLPLA       NOV4b   SSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGD-IVRYRC       NOV4c   QICLYFVTVPKDY-VVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSGSHTG-ESLPLA       NOV4d   QICLYFVTVPKDY-VVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSGSHTG-ESLPLA       NOV4e   QICLYFVTVPKDYGVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSGSHTG-ESLPLA       NOV4f   QICLYFVTVPKDYGVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSGSHTGGESLPLA       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   QICLYFVTVPKDY-VVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSGSHTG-ESLPLA       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   TSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFE       NOV4b   LPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQT       NOV4c   TSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFE       NOV4d   TSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFE       NOV4e   TSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSVPEPRYGKPLGSDFSVGAIVRFE       NOV4f   TSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFE       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   TSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFE       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   CNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSL       NOV4b   CSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSN       NOV4c   CNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSL       NOV4d   CNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSL       NOV4e   CNSGYALQGSPEIECLPVPGAIAQWNVSAPTCVVPCGGNLTERRGTTLSPGFPEPYLNSL       NOV4f   CNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSL       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   CNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSL       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   NCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSN       NOV4b   SVYLRWSSDHAYNRKGFKIRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLV       NOV4C   NCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSN       NOV4d   NCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSN       NOV4e   NCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSN       N0V4f   NCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSN       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   NCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSN       NOV4k   ------------------------------------------------------------       Nov41   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   QLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYA       NOV4b   GHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFGKEYTVGTKAVYSCSEGYH       NOV4c   QLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYA       NOV4d   QLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYA       NOV4e   QLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYA       NOV4f   QLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYA       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   QLYLHFYSDISVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYA       NOV4k   ------------------------------------------------------------       N0V4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ---MAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFGKEYTVGTKAVYSCSEGYH       NOV4o   ---MAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFGKEYTVGTKAVYSCSEGYH               NOV4a   LQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEENEGVILSPGFPGNYPSNMDCSWKIAL       NOV4b   LQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLML       NOV4c   LQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIAL       NOV4d   LQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIAL       NOV4e   LQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVILSPGFPGNYPSNNDCSWKIAL       NOV4f   LQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIAL       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   LQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEENEGVILSPGFPGNYPSNMDCSWKIAL       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   LQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLML       NOV4o   LQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLNL               NOV4a   PVGFGAHIQFLNFSTEPNHDYIEIRNGP-------------YETSRMMGRFSGSELPSSL       NOV4b   ICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCDELPIPPNGHRIGTLSVYGATAIF       NOV4c   PVGFGAHIQFLNFSTEPNHDYIEIRNGP-------------YETSRMNGRFSGSELPSSL       NOV4d   PVGFGAHIQFLNFSTEPNHDYIEIRNGP-------------YETSRMMGRFSGSELPSSL       NOV4e   PVGFGAHIQFLNFSTEPNHDYIEIRNGP-------------YETSRMMGRFSGSELPSSL       NOV4f   PVGFGAHIQFLNFSTEPNHDYIEIRNGP-------------YETSPMMGRFSGSELPSSL       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   PVGFGAHIQFLNFSTEPNHDYIEIRNGP-------------YETSRMMGRFSGSELPSSL       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSVYGATAIF       NOV4o   ICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSVYGATAIF               NOV4a   LSTSHETTVYFHSDHSQNRPGFKLEYQAYELQECPDPEPFANGIVRGAGYNVGQSVTFEC       NOV4b   SCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGENYSYRGSVVYQC       NOV4c   LSTSHETTVYFHSDHSQNRPGFKLEYQAYELQECPDPEPFANGIVRGAGYNVGQSVTFEC       NOV4d   LSTSHETTVYFHSDHSQNRPGFKLEYQAYELQECPDPEPFANGIVRGAGYNVGQSVTFEC       NOV4e   LSTSHETTVYFHSDHSQNRPGFKLEYQAYELQECPDPEPFANGIVRGAGYNVGQSVTFEC       N0V4f   LSTSHETTVYFHSDHSQNRPGFKLEYQAYELQECPDPEPFANGIVRGAGYNVGQSVTFEC       NOV4g   ------------------------------KLECPDPEPFANGIVRGAGYNVGQSVTFEC       NOV4h   ------------------------------KLECPDPEPFANGIVRGAGYNVGQSVTFEC       NOV4i   ------------------------------KLECPDPEPFANGIVRGAGYNVGQSVTFEC       NOV4j   LSTSHETTVYFHSDHSQNRPGFKLEYQAYELQECPDPEPFANGIVRGAGYNVGQSVTFEC       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   SCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGENYSYRGSVVYQC       NOV4o   SCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGENYSYRGSVVYQC               NOV4a   LPGYQLTGHPVLTCQHGTNRN----------WDHPLPKCEVPCGGNITSSNGTVYSPGFP       NOV4b   NAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFVCNP       NOV4c   LPGYQLTGHPVLTCQHGTNRN----------WDHPLPKCEVPCGGNITSSNGTVYSPGFP       NOV4d   LPGYQLTGHPVLTCQHGTNRN----------WDHPLPKCEVPCGGNITSSNGTVYSPGFP       NOV4e   LPGYQLTGHPVLTCQHGTNRN----------WDHPLPKCEVPCGGNITSSNGTVYSPGFP       NOV4f   LPGYQLTGHPVLTCQHGTNRN----------WDHPLPKCEVPCGGNITSSNGTVYSPGFP       NOV4g   LPGYQLTGHPVLTCQHGTNRN----------WDHSLPKCEVPCGGNITSSNGTVYSPGFP       NOV4h   LPGYQLTGHPVLTCQHGTNRN----------WDHPLPKCEVPCGGNITSSNGTVYSPGFP       NOV4i   LPGYQLTGHPVLTCQHGTNRN----------WDHPLPKCEVPCGGNITSSNGTVYSPGFP       NOV4j   LPGYQLTGHPVLTCQHGTNRN----------WDHPLPKCEVPCGGNITSSNGTVYSPGFP       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   NAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFVCNP       NOV4o   NAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFVCNP               NOV4a   SPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKK       NOV4b   GYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYR       NOV4c   SPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKK       NOV4d   SPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKK       NOV4e   SPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKK       NOV4f   SPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKK       NOV4g   SPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKK       NOV4h   SPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKK       NOV4i   SPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKK       NOV4j   SPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKK       NOV4k   ------------------------------------------------------------       NOV4l   ---AEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYR       NOV4m   ----------------------------------------------------MGYTLIYS       NOV4n   GYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYR       NOV4o   GYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYR               NOV4a   TVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVR       NOV4b   C--NHGFYLLGTPVLSCQGDGTWDRPRPQCLLVSCGHPGSPPHSQMSGDS--YTVGAVVR       NOV4c   TVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVR       NOV4d   TVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVR       NOV4e   TVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVR       NOV4f   TVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVR       NOV4g   TVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVR       NOV4h   TVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVR       NOV4i   TVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTTLPNAEVVTENEEFNIGDIVR       NOV4j   TVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVR       NOV4k   ------------------------------------------------------------       NOV4l   C--NHGFYLLGTPVLSCQGDGTWDRPRPQCLLVSCGHPGSPPHSQMSGDS--YTVGAVVR       NOV4m   C-QEGFSLKGGSEHRTCKADGSWTGKPPICLEVR---PSGRPINTAREPP--------LT       NOV4n   CX-TTASTSWATPVLSCQGDGTWDRPRPQCLLVSCGHPGSPPHSQMSGDS--YTVGAVVR       NOV4o   C--NHGFYLLGTPVLSCQGDGTWDRPRPQCLLVSCGHPGSPPHSQMSGDS--YTVGAVVR               NOV4a   YRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQ       NOV4b   YSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVM       NOV4c   YRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQ       NOV4d   YRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQ       NOV4e   YRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQ       NOV4f   YRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQ       NOV4g   YRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQ       NOV4h   YRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQ       NOV4i   YRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQ       NOV4j   YRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQ       NOV4k   ------------------------------------------------------------       NOV4l   YSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVM       NOV4m   QALIPGDVFAKNSLWKGAYEYQGKKQ-PAMLRVTGFQVANSKVNATMIDHSG-VELHLAG       NOV4n   YSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVM       NOV4o   YSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVN               NOV4a   FQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTS       NOV4b   RFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPG--------TPSNARVVFSDG       NOV4c   FQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTS       NOV4d   FQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTS       NOV4e   FQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTS       NOV4f   FQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTS       NOV4g   FQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTS       NOV4h   FQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTS       NOV4i   FQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTS       NOV4j   FQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTS       NOV4k   ------------------------------------------------------------       NOV4l   RFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPG--------TPSNARVVFSDG       NOV4m   TYKKEDFHLLLQVYQITGPVEIFMN-KFKDDHWALDGHVS--------SANSPPPLTPRS       NOV4n   RFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPG--------TPSNARVVFSDG       NOV4o   RFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPG--------TPSNARVVFSDG               NOV4a   SSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGY       NOV4b   LVFSSSIVYECREGYYATGLLSRHCSVNGTWTGS----------D---------------       NOV4c   SSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGY       NOV4d   SSNSVYLRWSSDHAYNRKGFKIRYSALSCGLP----------------------------       NOV4e   SSNSVYLRWSSDHAYNRKGFKIRYSALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYH       NOV4f   SSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGY       NOV4g   SSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGY       NOV4h   SSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGY       NOV4i   SSNSVYLRWSSDHAYNRKGFKIRYSA----------------------------------       NOV4j   SSNSVYLRWSSDHAYNRKGFKIRYVD----------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   LVFSSSIVYECREGYYATGLLSRHCSVNGTWTGS----------D---------------       NOV4m   LAGKRRTKGCANP-----------------------------------------------       NOV4n   LVFSSSIVYECREGYYATGLLSRHCSVNGTWTGS----------D---------------       NOV4o   LVFSSSIVYECREGYYATGLLSRHCSVNGTWTGS----------D---------------               NOV4a   RLVGHSMAICTRHPQGYH------------------------------------------       NOV4b   ------------------------------------------------------------       NOV4c   RLVGHSMAICTRHPQGYH------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   LQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLML       NOV4f   RLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAP----------------------       NOV4g   RLVGHSMAICTRHPQGYH------------------------------------------       NOV4h   RLVGHSMAICTRHPQGYH------------------------------------------       NOV4i   ---------LS-------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   ------------------------------------------------------------       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   ICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSVYGATAIF       NOV4f   ------------------------------------KNGMVFGKEYTVGTKAMYSCSEGY       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   ------------------------------------------------------------       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   SCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGENYSYRGSVTYQC       NOV4f   HLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLM       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   ------------------------------------------------------------       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   NAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFVCNP       N0V4f   LICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSVYGATAI       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   ------------------------------------------------------------       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   GYMAEGAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYR       NOV4f   FSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGENYSYRGSVVYQ       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   ------------------------------------------------------------       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   CNHGFYLLGTPVLSCQGDGTWDRPRPQCLLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCI       NOV4f   CNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCI       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   ------------------------------------------------------------       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   GKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSC       NOV4f   GKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSC       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   ------------------------------------------------------------       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   EAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECR       NOV4f   EAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECR       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   -----------------LWSEAIPLCQALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEG       NOV4b   -----------------------PECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPG       NOV4c   -----------------LWSEAIPLCQALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEG       NOV4d   ----------------------------------EAPKNGMVFGKEYTVGTKAMYSCSEG       NOV4e   EGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPG       NOV4f   EGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPG       NOV4g   -----------------LWSEAIPLCQALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEG       NOV4h   -----------------LWSEAIPLCQALSCGLPEAPKNGMVFGKEYTVGTKAVYSCSEG       NOV4i   ------------------------------CGLPEAPKNGMVFGKEYTVGTKAMYSCSEG       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   -----------------------PECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPG       NOV4m   ------------------------------------------------------------       NOV4n   -----------------------PECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPG       NOV4o   -----------------------PECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPG               NOV4a   YHLQAGAEATAECLDTGLWSNRNVPPQCVP---------VTCPDVSSISVEHGRWRLIFE       NOV4b   YMMESHRVSVLSCTKDRThNGTKPVCKALMCK--------PPPLI--------PNGKVVG       NOV4c   YHLQAGAEATAECLDTGLWSNRNVPPQCVRESSGNGGGSVTCPDVSSISVEHGRWRLIFE       NOV4d   YHLQAGAEATAECLDTGLWSNRNVPPQCVP---------VTCPDVSSISVEHGRWRLIFE       NOV4e   YMMESHRVSVLSCTKDRTWNGTKPVCKALMCK--------PPPLIP--------NGKVVG       NOV4f   YMMESHRVSVLSCTKDRTWNGTKPVCKALMCK--------PPPLIP--------NGKVVG       NOV4g   YHLQAGAEATAECLDTGLWSNRNVPPQCVP---------VTCPDVSSISVEHGRWRLIFE       NOV4h   YHLQAGAEATAECLDTGLWSNRNVPPQCVP---------VTCPDVSSISVEHGRWRLIFE       NOV4i   YHLQAGAEATAECLDTGLWSNPNVPPQCVP---------VTCPDVSSISVEHGRWRPIFE       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   YMMESHRVSVLSCTKDRTWNGTKPVCKALMCK--------PPPLI--------PNGKVVG       NOV4m   ------------------------------------------------------------       NOV4n   YMMESHRVSVLSCTKDRTWNGTKPVCKALMCK--------PPPLI--------PNGKVVG       NOV4o   YMMESHRVSVLSCTKDRTWNGTKPVCKALMCK--------PPPLI--------PNGKVVG               NOV4a   TQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIG       NOV4b   SDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTG--ELPQCFPVFCGDPGVPSRGRRED       NOV4c   TQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIG       NOV4d   TQYQFQAQLMLICDPGYYYTGQRVIRCQMJGKWSLGDSTPTCRIISCGELPIPPNGHRIG       NOV4e   SDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTG--ELPQCFPVFCGDPGVPSRGRRED       NOV4f   SDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTG--ELPQCFPVFCGDPGVPSRGRRED       NOV4g   TQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIG       NOV4h   TQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIG       NOV4i   TQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIG       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   SDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTG--ELPQCFPVFCGDPGVPSRGRRED       NOV4m   ------------------------------------------------------------       NOV4n   SDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTG--ELPQCFPVFCGDPGVPSRGRRED       NOV4o   SDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTG--ELPQCFPVFCGDPGVPSRGRRED               NOV4a   TLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGS------------------------       NOV4b   RGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQP---------------------S       NOV4c   TLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLATQTKLHSIFYKLLFDVLS       NOV4d   TLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGS------------------------       NOV4e   RGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQP---------------------S       NOV4f   RGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQP---------------------S       NOV4g   TLSVYGATATFSCNSGYTLVGSRVRECMANGLWSGS------------------------       NOV4h   TLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGS------------------------       NOV4i   TLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGS------------------------       NOV4j   ------------------------------------------------------------       NOV4k   -----KSSVSFSCHPPLVLVGSPRLRFCQSDGTWSGTQP--------------------S       NOV4l   RGFSYRSSVSFSCHPPLVLVGSPRLRFCQSDGTWSGTQP---------------------       NOV4m   ------------------------------------------------------------       NOV4n   RGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQP---------------------S       NOV4o   RGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQP---------------------S               NOV4a   -EVRCLAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKT       NOV4b   CIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTP       NOV4c   SPSLTKAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKT       NOV4d   -EVRCLAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRTCQQDHHWSGKT       NOV4e   CIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTP       NOV4f   CIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTP       NOV4g   -EVRCLAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRTCQQDHHWSGKT       NOV4h   -EVRCIAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKT       NOV4i   -EVRCLAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKT       NOV4j   ------------------------------------------------------------       NOV4k   CIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTP       NOV4l   CIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTP       NOV4m   ------------------------------------------------------------       NOV4n   CIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTP       NOV4o   CIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTP               NOV4a   PFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFVCNPGYMAEG--AARSQCLASGQWSDML       NOV4b   PDCVPHHCRQPETPTHANVGALDLPSMGYTLITPARRASPSR--VAPSTAPARRMAAGQA       NOV4c   PFCVHVKQQLLLLLLLLCDDD----DDE--------------------------------       NOV4d   PFCQLPVDTQATLSTASLRVTS-LTSTMWSSLFATLGIWLRG--LLGPNAWPAGNGVTCC       NOV4e   PDCVPHHCRQPETPTHANVGALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKP       NOV4f   PDCVPHHCRQPETPTHANVGALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKP       NOV4g   PFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFVCNPGYMAEG--AARSQCLASGQWSDML       NOV4h   PFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFVCNPGYMAEG--AARSQCLASGQWSDML       NOV4i   PFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFVCNPGYMAEG--AARSQCLASGQWSDML       NOV4j   ------------------------------------------------------------       NOV4k   PDCVP-------------------------------------------------------       NOV4l   PDCVPHHCRQPETPTHANVGALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKP       NOV4m   ------------------------------------------------------------       NOV4n   PDCVPHHCRQPETPTHANVGALDLPSMGYTLITPARRASPSR--VAPSTAPARRMAAGQA       NOV4o   PDCVPHHCRQPETPTHANVGALDLPSMGYTLITPARRASPSR--VAPSTAPARRMAAGQA               NOV4a   PTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWD       NOV4b   SRPSAWR-SGPVGDPSTLPGSHRSPKP---------------------------------       NOV4c   -DDGSGAITCGHPGNPVNGLTQGNQFNLNDVVKFVCNPGYMAEGAARSQCLASGQWSDML       NOV4d   PPAESSTVQILDTKKIVFVRSTPAARTGSASAPLCLTGATTASTSWAPQCSAARENAHGT       NOV4e   PICLEVRPNGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKKQPAMLRVTGFQVA       NOV4f   PICLEVRPNGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKKQPAMLRVTGFQVA       NOV4g   PTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWD       NOV4h   PTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWD       NOV4i   PTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWD       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   PICLEVRPSGRPINIAREPPLTQALIPGDVFAKNSLWKG---------------------       NOV4m   ------------------------------------------------------------       NOV4n   SRPSAWQRSGPVGDPSTLPGSHRSPKP---------------------------------       NOV4o   SRPSAWR-SGPVGDPSTLPGSHRSPKP---------------------------------               NOV4a   RPRPQCLLVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGS       NOV4b   ------------------------------------------------------------       NOV4c   PTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWD       NOV4d   VPAPSVSVSSGVLWPSGLPASLPDVWRQLYCGSSGAVQLHRQAYSGGKQHPHVWAGWTLD       NOV4e   NSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKFKDDHWALDGHVSS       NOV4f   NSKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKFKDDHWALDGHVSS       NOV4g   RPRPQCLCKVD-------------------------------------------------       NOV4h   RPRPQCLCKVD-------------------------------------------------       NOV4i   RPRPQCLCKVD-------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   LPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSG       NOV4b   ------------------------------------------------------------       NOV4c   RPRPQCLCK---------------------------------------------------       NOV4d   WLPPSLLRNQRGSLR---------------------------------------------       NOV4e   ESSGATFIYQGSVKGQGFGQFGFQRLDLRLLESDPESIGRHFASNSSSVAAAILVPFIAL       NOV4f   ESSGATFIYQGSVKGQGFGQFGFQRLDLRLLESDPESIGRHFASNSSSVAAAILVPFIAL       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   SQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGS       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   IIAGFVLYLYKHRRRPKVPFNGYAGHENTNVPATFENPMYDRNIQPTDIMASEAEFTVST       NOV4f   IIAGFVLYLYKHRRRPKVPFNGYAGHENTNVRATFENPMYDRNIQPTDIMASEAEFTVST       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   DPECLVINCGDPGIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGT       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   VCTAV-------------------------------------------------------       NOV4f   VCTAV-------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   KPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELP       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   ------------------------------------------------------------       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   QCFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSC       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   ------------------------------------------------------------       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   IDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPP       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   ------------------------------------------------------------       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   DCVPHHCRQPETPTHANVGALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPP       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   ------------------------------------------------------------       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   ICLEVRPNGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKKQPAMLRVTGFQVAN       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   ------------------------------------------------------------       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       Nov4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   SKVNATMIDHSGVELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKFKDDHWALDGHVSSE       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   ------------------------------------------------------------       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   SSGATFIYQGSVKGQGFGQFGFQRLDLRLLESDPESIGRBFASNSSSVAAAILVPFIALI       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   ------------------------------------------------------------       NOV4f   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   IAGFVLYLYKHRRRPKVPFNGYAGHENTNVRATFENPMYDRNIQPTDIMASEAEFTVSTV       NOV4b   ------------------------------------------------------------       NOV4c   ------------------------------------------------------------       NOV4d   ------------------------------------------------------------       NOV4e   ------------------------------------------------------------       NOV4g   ------------------------------------------------------------       NOV4h   ------------------------------------------------------------       NOV4i   ------------------------------------------------------------       NOV4j   ------------------------------------------------------------       NOV4k   ------------------------------------------------------------       NOV4l   ------------------------------------------------------------       NOV4m   ------------------------------------------------------------       NOV4n   ------------------------------------------------------------       NOV4o   ------------------------------------------------------------               NOV4a   CTAV       NOV4b   ----       NOV4d   ----       NOV4e   ----       NOV4f   ----       NOV4g   ----       NOV4h   ----       NOV4i   ----       NOV4j   ----       NOV4k   ----       NOV4l   ----       NOV4m   ----       NOV4n   ----       NOV4o   ----               NOV4a   (SEQ ID NO: 32)       NOV4b   (SEQ ID NO: 34)       NOV4c   (SEQ ID NO: 36)       NOV4d   (SEQ ID NO: 38)       NOV4e   (SEQ ID NO: 40)       NOV4f   (SEQ ID NO: 42)       NOV4g   (SEQ ID NO: 44)       NOV4h   (SEQ ID NO: 46)       NOV4i   (SEQ ID NO: 48)       NOV4j   (SEQ ID NO: 50)       NOV4k   (SEQ ID NO: 52)       NOV4l   (SEQ ID NO: 54)       NOV4m   (SEQ ID NO: 56)       NOV4n   (SEQ ID NO: 58)       NOV4o   (SEQ ID NO: 60)                  
 
      Further analysis of the NOV4a protein yielded the following properties shown in Table 4C.  
               TABLE 4C                       Protein Sequence Properties NOV4a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 0; pos. chg 0; neg. chg 0           H-region:   length 15; peak value 1.77           PSG score:   −2.63                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −8.90           possible cleavage site: between 50 and 51                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 3           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 3472-3488               −11.52                             PERIPHERAL   Likelihood = 0.79 (at 1806)                         ALOM score: −11.52 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 3479           Charge difference: 7.0 C(5.5)-N(−1.5)           C &gt; N: C-terminal side will be inside                 &gt;&gt;&gt; Single TMS is located near the C-terminus       &gt;&gt;&gt; membrane topology: type Nt (cytoplasmic tail 1 to 3471)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:    0   Hyd Moment(75):   6.28           Hyd Moment(95):    5.99   G content:   3           D/E content:    1   S/T content:   2                         Score: −5.81       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: KHRR (3) at 3492           pat4: HRRR (3) at 3493           pat4: RRRP (4) at 3494           pat4: RRPK (4) at 3495           pat7: PERGKRL (4) at 327           pat7: PSRGRRE (4) at 3135           bipartite: none           content of basic residues: 6.9%           NLS Score: 1.09       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: found       ILPN at 2237       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: GQNCTF       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: found                         LL at 474           LL at 818           LL at 956           LL at 1087           LL at 1141           LL at 1228           LL at 1316           LL at 1664           LL at 1854           LL at 2027           LL at 2164           LL at 2207           LL at 2298           LL at 2361           LL at 2807           LL at 2829           LL at 2988           LL at 3222           LL at 3390           LL at 3391                 checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 70.6       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         34.8%: nuclear           26.1%: cytoplasmic            8.7%: Golgi            8.7%: mitochondrial            8.7%: endoplasmic reticulum            4.3%: vacuolar            4.3%: vesicles of secretory system            4.3%: peroxisomal                 &gt;&gt; prediction for CG50377-04 is nuc (k = 23)                  
 
      A search of the NOV4a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 4D.  
               TABLE 4D                          Geneseq Results for NOV4a                                         NOV4a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               ABG79168   Human cub and sushi domain   283 . . . 3273   2943/3019 (97%)   0.0           containing protein #1 -  Homo sapiens ,    36 . . . 3052   2958/3019 (97%)           3104 aa. [WO200264791-A2, 22-AUG-           2002]       ABG79169   Human cub and sushi domain   283 . . . 2829   2498/2634 (94%)   0.0           containing protein #2 -  Homo sapiens ,    36 . . . 2667   2512/2634 (94%)           2669 aa. [WO200264791-A2, 22-AUG-           2002]       AAE20789   Human C3b/C4b complement receptor   437 . . . 3546   2010/3110 (64%)   0.0           like protein #2 -  Homo sapiens , 3100    1 . . . 3100   2479/3110 (79%)           aa. [WO200210199-A2, 07-FEB-2002]       AAE20901   Human C3b/C4b complement receptor   437 . . . 3546   2009/3110 (64%)   0.0           like protein #2, alternative version -    1 . . . 3100   2478/3110 (79%)             Homo sapiens , 3100 aa.           [WO200210199-A2, 07-FEB-2002]       AAE20788   Rat C3b/C4b complement receptor like   442 . . . 3546   1998/3105 (64%)   0.0           protein -  Rattus rattus , 3095 aa.    1 . . . 3095   2474/3105 (79%)           [WO200210199-A2, 07-FEB-2002]                  
 
      In a BLAST search of public sequence databases, the NOV4a protein was found to have homology to the proteins shown in the BLASTP data in Table 4E.  
               TABLE 4E                          Public BLASTP Results for NOV4a                                         NOV4a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q923L3   CSMD1 -  Mus musculus  (Mouse),   1 . . . 3546   2301/3546 (64%)   0.0           3564 aa.   29 . . . 3564    2835/3546 (79%)       AAK73475   CUB and sushi multiple domains 1   1 . . . 3546   2298/3548 (64%)   0.0           protein -  Homo sapiens  (Human),   29 . . . 3566    2830/3548 (78%)           3566 aa.       CAD26764   Sequence 6 from Patent   437 . . . 3546    2010/3110 (64%)   0.0           WO0210199 -  Homo sapiens     1 . . . 3100   2479/3110 (79%)           (Human), 3100 aa (fragment).       CAD26836   Sequence 3 from Patent   442 . . . 3546    1998/3105 (64%)   0.0           WO0210199 -  Rattus rattus  (Black   1 . . . 3095   2474/3105 (79%)           rat), 3095 aa (fragment).       CAD26763   Sequence 1 from Patent   469 . . . 3546    1987/3078 (64%)   0.0           WO0210199 -  Homo sapiens     2 . . . 3069   2451/3078 (79%)           (Human), 3069 aa.                  
 
      PFam analysis predicts that the NOV4a protein contains the domains shown in the Table 4F.  
               TABLE 4F                          Domain Analysis of NOV4a                                             Identities/                       Similarities           Pfam   NOV4a Match   for the   Expect           Domain   Region   Matched Region   Value                       CUB    4 . . . 109   39/116 (34%)      2e−27                   80/116 (69%)            sushi   117 . . . 174   22/65 (34%)   4.7e−10                   46/65 (71%)           CUB   180 . . . 281   45/116 (39%)      5e−28                   79/116 (68%)            sushi   321 . . . 378   24/65 (37%)   3.7e−11                   44/65 (68%)           CUB   383 . . . 491   43/118 (36%)    1.7e−30                   84/118 (71%)            sushi   499 . . . 552   19/63 (30%)   4.9e−12                   40/63 (63%)           CUB   554 . . . 661   43/116 (37%)      2e−33                   81/116 (70%)            sushi   669 . . . 726   16/65 (25%)   5.7e−08                   39/65 (60%)           CUB   730 . . . 835   46/116 (40%)    1.2e−32                   80/116 (69%)            sushi   845 . . . 898   17/63 (27%)   1.8e−08                   36/63 (57%)           CUB    902 . . . 1009   40/119 (34%)    1.7e−19                   79/119 (66%)            sushi   1017 . . . 1072   21/62 (34%)   1.8e−10                   44/62 (71%)           CUB   1076 . . . 1181   34/117 (29%)    1.6e−24                   81/117 (69%)            sushi   1189 . . . 1245   17/65 (26%)   5.1e−10                   45/65 (69%)           CUB   1249 . . . 1355   42/116 (36%)    1.1e−21                   73/116 (63%)            sushi   1363 . . . 1419   20/64 (31%)   2.1e−06                   40/64 (62%)           CUB   1423 . . . 1529   54/117 (46%)    4.2e−39                   89/117 (76%)            sushi   1537 . . . 1594   21/65 (32%)   1.2e−09                   42/65 (65%)           CUB   1598 . . . 1704   40/117 (34%)    7.9e−15                   70/117 (60%)            sushi   1715 . . . 1772   18/65 (28%)   4.5e−06                   40/65 (62%)           CUB   1776 . . . 1881   42/116 (36%)      4e−31                   82/116 (71%)            sushi   1889 . . . 1944   19/64 (30%)   1.8e−10                   43/64 (67%)           CUB   1948 . . . 2053   45/116 (39%)    1.5e−29                   77/116 (66%)            sushi   2061 . . . 2116   23/64 (36%)   7.8e−13                   47/64 (73%)           CUB   2120 . . . 2224   35/116 (30%)    6.4e−24                   75/116 (65%)            sushi   2232 . . . 2289   19/65 (29%)   1.4e−09                   46/65 (71%)           CUB   2293 . . . 2401   41/117 (35%)    5.1e−20                   79/117 (68%)            sushi   2406 . . . 2464   20/65 (31%)   4.1e−08                   39/65 (60%)           sushi   2469 . . . 2526   19/65 (29%)   6.5e−09                   43/65 (66%)           sushi   2531 . . . 2591   17/67 (25%)   5.5e−09                   43/67 (64%)           sushi   2596 . . . 2649   20/63 (32%)   5.1e−13                   41/63 (65%)           sushi   2654 . . . 2707   22/63 (35%)   2.2e−13                   40/63 (63%)           sushi   2712 . . . 2765   18/63 (29%)   1.5e−13                   41/63 (65%)           sushi   2770 . . . 2828   20/67 (30%)   3.2e−14                   47/67 (70%)           sushi   2833 . . . 2886   19/63 (30%)   1.4e−09                   39/63 (62%)           sushi   2894 . . . 2947   17/63 (27%)   2.1e−13                   40/63 (63%)           sushi   2952 . . . 3006   18/63 (29%)   5.7e−08                   40/63 (63%)           sushi   3011 . . . 3066   19/65 (29%)   6.8e−09                   42/65 (65%)           sushi   3071 . . . 3124   24/63 (38%)   4.9e−14                   46/63 (73%)           sushi   3129 . . . 3182   18/63 (29%)   3.1e−11                   42/63 (67%)           sushi   3190 . . . 3244   20/63 (32%)   3.4e−09                   45/63 (71%)           sushi   3249 . . . 3304   18/64 (28%)   6.1e−10                   39/64 (61%)                      
 
     Example 5  
      The NOV5 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 5A.  
               TABLE 5A                       NOV5 Sequence Analysis                                                        NOV5a, CG50389-04   SEQ ID NO: 65   1897 bp               DNA Sequence   ORF Start: ATG at 51   ORF Stop: TAA at 1785                       GAATTCCGCCCGCCCACGGCGGCGGGGAAATACCTAGGCATGGAAGTGGC   ATG ACAGGGCTCGTGTCC           CTGTCATATTTTCCACTCTCCACGAGGTCCTGCGCGCTTCAATCCTGCAGGCAGCCCGGTTTGGGGAT       GTGGTCCTTGCTGCTCTGCGGGTTGTCCATCGCCCTTCCACTGTCTGTCACAGCAGATGGATGCAAGG       ACATTTTTATGAAAAATGAGATACTTTCAGCAAGCCAGCCTTTTGCTTTTAATTGTACATTCCCTCCC       ATAACATCTGGGGAAGTCAGTGTAACATGGTATAAAAATTCTAGCAAAATCCCAGTGTCCAAAATCAT       ACAGTCTAGAATTCACCAGGACGAGACTTGGATTTTGTTTCTCCCCATGGAATGGGGGGACTCAGGAG       TCTACCAATGTGTTATAAAGGGTAGAGACAGCTGTCATAGAATACATGTAAACCTAACTGTTTTTGAA       AAACATTGGTGTGACACTTCCATAGGTGGTTTACCAAATTTATCAGATGAGTACAAGCAAATATTACA       TCTTGGAAAAGATGATAGTCTCACATGTCATCTGCACTTCCCGAAGAGTTGTGTTTTGGGTCCAATAA       AGTGGTATAAAGACTGTAACGAGATTAAAGGGGAGCGGTTCACTGTTTTGGAAACCAGGCTTTTGGTG       AGCAATGTCTCGGCAGAGGACAGAGGGAACTACGCGTGTCAAGCCATACTGACACACTCAGGGAAGCA       GTACGAGGTTTTAAATGGCATCACTGTGAGCATTAGTACCACTCTGATTGTGGACTGCAATGTAACAG       ACACCAAGGATAATACAAATCTACGATGCTGGAGAGTCAATAACACTTTGGTGGATGATTACTATGAT       GAATCCAAACGAATCAGAGAAGGGGTGGAAACCCATGTCTCTTTTCGGGAACATAATTTGTACACAGT       AAACATCACCTTCTTGGAAGTGAAAATGGAAGATTATGGCCTTCCTTTCATGTGCCACGCTGGAGTGT       CAACAGCATACATTATATTACAGCTCCCAGCTCCGGATTTTCGAGCTTACTTGATAGGAGGGCTTATC       GCCTTGGTGGCTGTGGCTGTGTCTGTTGTGTACATATACAACATTTTTAAGATCGACATTGTTCTTTG       GTATCGAAGTGCCTTCCATTCTACAGAGACCATAGTAGATGGGAAGCTGTATGACGCCTATGTCTTAT       ACCCCAAGCCCCACAAGGAAAGCCAGAGGCATGCCGTGGATGCCCTGGTGTTGAATATCCTGCCCGAG       GTGTTGGAGAGACAATGTGGATATAAGTTGTTTATATTCGGCAGAGATGAATTCCCTGGACAAGCCGT       GGCCAATGTCATCGATGAAAACGTTAAGCTGTGCAGGAGGCTGATTGTCATTGTGGTCCCCGAATCGC       TGGGCTTTGGCCTGTTGAAGAACCTGTCAGAAGAACAAATCGCGGTCTACAGTGCCCTGATCCAGGAC       GGGATGAAGGTTATTCTCGTTGAGCTGGAGAAAATCGAGGACTACACAGTCATGCCAGAGTCAATTCA       GTACATCAAACAGAAGCATGGTGCCATCCGGTGGCATGGGGACTTCACGGAGCAGTCACAGTGTATGA       AGACCAAGTTTTGGAAGACAGTGAGATACCACATGCCACCCAGAAGGTGTCGGCCGTTTCCTCCGGTC       CAGCTGCTGCAGCACACACCTTGCTGCCGCACCGCAGGCCCAGAACTAGGCTCAAGAAGAAAGAAGTG       TACTCTCACGACTGGC TAA   GACTTGCTGGACTGACACCTATGGCTGGAAGATGACTTGTTTTGCTCCA           TGTCTCCTCATTCCTACACCTATTTTCTGCTGCAGGATGAGGCTAGGGTTAGCATTCTAGA                                                   NOV5a, CG50389-04   SEQ ID NO: 66   578 aa   MW at 65576.2kD               Protein Sequence                     MTGLVSLSYFPLSTRSCALQSCRQPGLGMWSLLLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAF           NCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHV       NLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVL       ETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSISTTLIVDCNVTDTKDNTNLRCWRVNNTL       VDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFRAY       LIGGLIALVAVAVSVVYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALV       LNILPEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIVIVVPESLGFGLLKNLSEEQIAVY       SALIQDGMKVILVELEKIEDYTVMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRRC       RPFPPVQLLQHTPCCRTAGPELGSRRKKCTLTTG                                             NOV5b, CG50389-06   SEQ ID NO: 67   1802 bp               DNA Sequence   ORF Start: ATG at 471   ORF Stop: TAA at 1743                       GGGATGTGGTCCTTGCTGCTCTGCGGGTTGTCCATCGCCCTTCCACTGTCTGTCACAGCAGGTACGTT               CCGTGTGTCCTCCGTTCCCAGAGGCTGCCCGAGTCCACAGGCTCCTGGCCTGTCATTGGGAGCCCCCG           GGGATCGCGTCAGCCCGAGCGCGGCTCCTTCCCCTCCCCAGACCGCCAGGCGGAGTTCCGCGGAAGAG           GAAACAGAGAACCACCAGCTCCACGTGCTCGGATGCTCAGCCCTGAATGTCGCCTTTGAGCTTGGAGA           TGGATGCAAGGACATTTTTATGAAAAATGAGATACTTTCAGCAAGCCAGCCTTTTGCTTTTAATTGTA           CATTCCCTCCCATAACATCTGGGGAAGTCAGTGTAACATGGTATAAAAATTCTAGCAAAATCCCAGTG           TCCAAAATCATACAGTCTAGAATTCACCAGGACGAGACTTGGATTTTGTTTCTCCCCATGGA   ATG GGG       GGACTCAGGAGTCTACCAATGTGTTATAAAGACTGTAACGAGATTAAAGGGGAGCGGTTCACTGTTTT       GGAAACCAGGCTTTTGGTGAGCAATGTCTCGGCAGAGGACAGAGGGAACTACGCGTGTCAAGCCATAC       TGACACACTCAGGGAAGCAGTACGAGGTTTTAAATGGCATCACTGTGAGCATTACAGAAAGAGCTGGA       TATGGAGGAAGTGTCCCTAAAATCATTTATCCAAAAAATCATTCAATTGAAGTACAGCTTGGTACCAC       TCTGATTGTGGACTGCAATGTAACAGACACCAAGGATAATACAAATCTACGATGCTGGAGAGTCAATA       ACACTTTGGTGGATGATTACTATGATGAATCCAAACGAATCAGAGAAGGGGTGGAAACCCATGCCTCT       TTTCGGGAACATAATTTGTACACAGTAAACATCACCTTCTTGGAAGTGAAAATGGAAGATTATGGCCT       TCCTTTCGTGTGCCACGCTGGAGTGTCCACAGCATACATTATATTACAGCTCCCAGCTCCGGATTTTC       GAGCTTACTTGATAGGAGGGCTTATCGCCTTGGTGGCTGTGGCTGTGTCTGTTGTGTACATATACAAC       ATTTTTAAGATCGACATTGTTCTTTGGTACCGAAGTGCCTTCCATTCTACAGAGACCATAGTAGATGG       GAAGCTGTATGACGCCTATGTCTTATACCCCAAGCCCCACAAGGAAAGCCAGAGGCATGCCGTGGATG       CCCTGGTGTTGAATATCCTGCCCGAGGTGTTGGAGAGACAATGTGGATATAAGTTGTTTATATTCGGC       AGAGATGAATTCCTTGGACAAGCCGTGGCCAATGTCATCGATGAAAACGTTAAGCTGTGCAGGAGGCT       GATTGTCATTGTGGTCCCCGAATCGCTGGGCTTTGGCCTGTTGAAGAACCTGTCAGAAGAACAAATCG       CGGTCTACAGTGCCCTGATCCAGGACGGGATGAAGGTTATTCTCATTGAGCTGGAGAAAATCGAGGAC       TACACAGTCATGCCAGAGTCAATTCAGTACATCAAACAGAAGCATGGTGCCATCCGGTGGCATGGGGA       CTTCACGGAGCAGTCACAGTGTATGAAGACCAAGTTTTGGAAGACAGTGAGATACCACATGCCGCCCA       GAAGGTGTCGGCCGTTTCCTCCGGTCCAGCTGCCGCAGCACACACCTTGCTACCGCACCGCAGGCCCA       GAACTAGGCTCAAGAAGAAAGAAGTGTACTCTCACGACTGGC TAA   GACTTGCTGGACTGACACCTATG           GCTGGAAGATGACTTGTTTTGCTCCATGTCTCCT                                                   NOV5b, CG50389-06   SEQ ID NO: 68   424 aa   MW at 48256.3kD               Protein Sequence                     MGGLRSLPMCYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITER           AGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETH       ASFREHNLYTVNITFLEVKMEDYGLPFVCHAGVSTAYIILQLPAPDFRAYLIGGLIALVAVAVSVVYI       YNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALVLNILPEVLERQCGYKLFI       FGRDEFLGQAVANVIDENVKLCRPLIVIVVPESLGFGLLKNLSEEQIAVYSALIQDGMKVILIELEKI       EDYTVMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRRCRPFPPVQLPQHTPCYRTA       GPELGSRRKKCTLTTG                                     NOV5c, 257448648   SEQ ID NO: 69   891 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GGATCCGATGGATGCAAGGACATTTTTATGAAAAATGAGATACTTTCAGCAAGCCAGCCTTTTGCTTT           TAATTGTACATTCCCTCCCATAACATCTGGGGAAGTCAGTGTAACATGGTATAAAAATTCTAGCAAAA       TCCCAGTGTCCAAAATCATACAGTCTAGAATTCACCAGGACGAGACTTGGATTTTGTTTCTCCCCATG       GAATGGGGGGACTCAGGAGTCTACCAATGTGTTATAAAGGGTAGAGACAGCTGTCATAGAATACATGT       AAACCTAACTGTTTTTGAAAAACATTGGTGTGACACTTCCATAGGTGGTTTACCAAATTTATCAGATG       AGTACAAGCAAATATTACATCTTGGAAAAGATGATAGTCTCACATGTCATCTGCACTTCCCGAAGAGT       TGTGTTTTGGGTCCAATAAAGTGGTATAAGGACTGTAACGAGATTAAAGGGGAGCGGTTCACTGTTTT       GGAAACCAGGCTTTTGGTGAGCAATGTCTCGGCAGAGGACAGAGGGAACTACGCGTGTCAAGCCATAC       TGACACACTCAGGGAAGCAGTACGAGGTTTTAAATGGCATCACTGTGAGCATTAGTACCACTCTGATT       GTGGACTGCAATGTAACAGACACCAAGGATAATACAAATCTACGATGCTGGAGAGTCAATAACACTTT       GGTGGATGATTACTATGATGAATCCAAACGAATCAGAGAAGGGGTGGAAACCCATGTCTCTTTTCGGG       AACATAATTTGTACACAGTAAACATCACCTTCTTGGAAGTGAAAATGGAAGATTATGGCCTTCCTTTC       ATGTGCCACGCTGGAGTGTCCACAGCATACATTATATTACAGCTCCCAGCTCCGGATTTTCGAGCTTA       CCTCGAG                                                 NOV5c, 257448648   SEQ ID NO: 70   297 aa   MW at 33848.1kD               Protein Sequence                     GSDGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPM           EWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKS       CVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSISTTLI       VDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPF       MCHAGVSTAYIILQLPAPDFRAYLE                                             NOV5d, CG50389-01   SEQ ID NO: 71   1769 bp               DNA Sequence   ORF Start: ATG at 45   ORF Stop: TGA at 477                     CGCCCGCCCACGGCGGCGGGGAAATACCTAGGCATGGAAGTGGCATGACAGGGCTCGTGTCCCTGTCA           TATTTTCCACTCTCCACGAGGTCCTGCGCGCTTCAATCCTGCAGGCAGCCCGGTTTGGGGATGTGGTC       CTTGCTGCTCTGCGGGTTGTCCATCGCCCTTCCACTGTCTGTCACAGCAGATGGATGCAAGGACATTT       TTATGAAAAATGAGATACTTTCAGCAAGCCAGCCTTTTGCTTTTAATTGTACATTCCCTCCCATAACA       TCTGGGGAAGTCAGTGTAACATGGTATAAAAATTCTAGCAAAATCCCAGTGTCCAAAATCATACAGTC       TAGAATTCACCAGGACGAGACTTGGATTTTGTTTCTCCCCATGGAATGGGGGGACTCAGGAGTCTACC       AATGTGTTATAAAGACTGTAACGAGATTAAAGGGGAGCGGTTCACTGTTTTGGAAACCAGGCTTTTGG         TGA   GCAATGTCTCGGCAGAGGACAGAGGGAACTACGCGTGTCAAGCCATACTGACACACTCAGGGAAC           CAGTACGAGGTTTTAAATGGCATCACTGTGAGCATTACAGAAAGAGCTGGATATGGAGGAAGTGTCCC           TAAAATCATTTATCCAAAAAATCATTCAATTGAAGTACAGCTTGGTACCACTCTGATTGTGGACTGCA           ATGTAACAGACACCAAGGATAATACAAATCTACGATGCTGGAGAGTCAATAACACTTTGGTGGATGAT           TACTATGATGAATCCAAACGAATCAGAGAAGGGGTGGAAACCCATGTCTCTTTTCGGGAACATAATTT           GTACACAGTAAACATCACCTTCTTGGAAGTGAAAATGGAAGATTATGGCCTTCCTTTCATGTGCCACG           CTGGAGTGTCCACAGCATACATTATATTACAGCTCCCAGCTCCGGATTTTCGAGCTTACTTGATAGGA           GGGCTTATCGCCTTGGTGGCTGTGGCTGTGTCTGTTGTGTACATATACAACATTTTTAAGATCGACAT           TGTTCTTTGGTATCGAAGTGCCTTCCATTCTACAGAGACCATAGTAGATGGGAAGCTGTATGACGCCT           ATGTCTTATACCCCAAGCCCCACAAGGAAAGCCAGAGGCATGCCGTGGATGCCCTGGTGTTGAATATC           CTGCCCGAGGTGTTGGAGAGACAATGTGGATATAAGTTGTTTATATTCGGCAGAGATGAATTCCCTGC           ACAAGCCGTGGCCAATGTCATCGATGAAAACGTTAAGCTGTGCAGGAGGCTGATTGTCATTGTGGTCC           CCGAATCGCTGGGCTTTGGCCTGTTGAAGAACCTGTCAGAAGAACAAATCGCGGTCTACAGTGCCCTG           ATCCAGGACGGGATGAAGGTTATTCTCATTGAGCTGGAGAAAATCGAGGACTACACAGTCATGCCAGA           GTCAATTCAGTACATCAAACAGAAGCATGGTGCCATCCGGTGGCATGGGGACTTCACGGAGCAGTCAC           AGTGTATGAAGACCAAGTTTTGGAAGACAGTGAGATACCACATGCCGCCCAGAAGGTGTCGGCCGTTT           CTCCGGTCCACGTGCCGCAGCACACACCTCTGTACCGCACCGCAGGCCCAGAACTAGGCTCAAGAAGA           AAGAAGTGTACTCTCACGACTGGCTAAGACTTGCTGGACTGACACCTATGGCTGGAAGATGACTTGTT           TTGCTCCATGTCTCCTCATTCCTACACCTATTTTCTGCTGCAGGATGAGGCTAGGGTTAGCATTCTAC           A                                                   NOV5d, CG50389-01   SEQ ID NO: 72   144 aa   MW at 15977.5kD               Protein Sequence                     MTGLVSLSYFPLSTRSCALQSCRQPGLGMWSLLLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAF           NCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKTVTRLKGSGS       LFWKPGFW                                             NOV5e, CG50389-02   SEQ ID NO: 73   1769 bp               DNA Sequence   ORF Start: ATG at 386   ORF Stop: TAG at 1619                       CGCCCGCCCACGGCGGCGGGGAAATACCTAGGCATGGAAGTGGCATGACAGGGCTCGTGTCCCTGTCA               TATTTTCCACTCTCCACGAGGTCCTGCGCGCTTCAATCCTGCAGGCAGCCCGGTTTGGGGATGTGGTC           CTTGCTGCTCTGCGGGTTGTCCATCGCCCTTCCACTGTCTGTCACAGCAGATGGATGCAAGGACATTT           TTATGAAAAATGAGATACTTTCAGCAAGCCAGCCTTTTGCTTTTAATTGTACATTCCCTCCCATAACA           TCTGGGGAAGTCAGTGTAACATGGTATAAAAATTCTAGCAAAATCCCAGTGTCCAAAATCATACAGTC           TAGAATTCACCAGGACGAGACTTGGATTTTGTTTCTCCCCATGGA   ATG GGGGGACTCAGGAGTCTACC       AATGTGTTATAAAGACTGTAACGAGATTAAAGGGGAGCGGTTCACTGTTTTGGAAACCAGGCTTTTGG       TGAGCAATGTCTCGGCAGAGGACAGAGGGAACTACGCGTGTCAAGCCATACTGACACACTCAGGGAAG       CAGTACGAGGTTTTAAATGGCATCACTGTGAGCATTACAGAAAGAGCTGGATATGGAGGAAGTGTCCC       TAAAATCATTTATCCAAAAAATCATTCAATTGAAGTACAGCTTGGTACCACTCTGATTGTGGACTGCA       ATGTAACAGACACCAAGGATAATACAAATCTACGATGCTGGAGAGTCAATAACACTTTGGTGGATGAT       TACTATGATGAATCCAAACGAATCAGAGAAGGGGTGGAAACCCATGTCTCTTTTCGGGAACATAATTT       GTACACAGTAAACATCACCTTCTTGGAAGTGAAAATGGAAGATTATGGCCTTCCTTTCATGTGCCACG       CTGGAGTGTCCACAGCATACATTATATTACAGCTCCCAGCTCCGGATTTTCGAGCTTACTTGATAGGA       GGGCTTATCGCCTTGGTGGCTGTGGCTGTGTCTGTTGTGTACATATACAACATTTTTAAGATCGACAT       TGTTCTTTGGTATCGAAGTGCCTTCCATTCTACAGAGACCATAGTAGATGGGAAGCTGTATGACGCCT       ATGTCTTATACCCCAAGCCCCACAAGGAAAGCCAGAGGCATGCCGTGGATGCCCTGGTGTTGAATATC       CTGCCCGAGGTGTTGGAGAGACAATGTGGATATAAGTTGTTTATATTCGGCAGAGATGAATTCCCTGG       ACAAGCCGTGGCCAATGTCATCGATGAAAACGTTAAGCTGTGCAGGAGGCTGATTGTCATTGTGGTCC       CCGAATCGCTGGGCTTTGGCCTGTTGAAGAACCTGTCAGAAGAACAAATCGCGGTCTACAGTGCCCTG       ATCCAGGACGGGATGAAGGTTATTCTCATTGAGCTGGAGAAAATCGAGGACTACACAGTCATGCCAGA       GTCAATTCAGTACATCAAACAGAAGCATGGTGCCATCCGGTGGCATGGGGACTTCACGGAGCAGTCAC       AGTGTATGAAGACCAAGTTTTGGAAGACAGTGAGATACCACATGCCGCCCAGAAGGTGTCGGCCGTTT       CTCCGGTCCACGTGCCGCAGCACACACCTCTGTACCGCACCGCAGGCCCAGAAC TAG   GCTCAAGAAGA           AAGAAGTGTACTCTCACGACTGGCTAAGACTTGCTGGACTGACACCTATGGCTGGAAGATGACTTGTT           TTGCTCCATGTCTCCTCATTCCTACACCTATTTTCTGCTGCAGGATGAGGCTAGGGTTAGCATTCTAG           A                                                   NOV5e, CG50389-02   SEQ ID NO: 74   411 aa   MW at 46893.7kD               Protein Sequence                     MGGLRSLPMCYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITER           AGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETH       VSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFRAYLIGGLIALVAVAVSVVYI       YNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALVLNILPEVLERQCGYKLFI       FGRDEFPGQAVANVIDENVKLCRRLIVIVVPESLGFGLLKNLSEEQIAVYSALIQDGMKVILIELEKI       EDYTVMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRRCRPFLRSTCRSTHLCTAPQ       AQN                                             NOV5f, CG50389-03   SEQ ID NO: 75   1827 bp               DNA Sequence   ORF Start: ATG at 65   ORF Stop: TAA at 1715   J                       GTCATATTTTCCACTCTCCACGAGGTCCTGCGCGCTTCAATCCTGCAGGCAGCCCGGTTTGGGG   ATG T           GGTCCTTGCTGCTCTGCGGGTTGTCCATCGCCCTTCCACTGTCTGTCACAGCAGATGGATGCAAGGAC       ATTTTTATGAAAAATGAGATACTTTCAGCAAGCCAGCCTTTTGCTTTTAATTGTACATTCCCTCCCAT       AACATCTGGGGAAGTCAGTGTAACATGGTATAAAAATTCTAGCAAAATCCCAGTGTCCAAAATCATAC       AGTCTAGAATTCACCAGGACGAGACTTGGATTTTGTTTCTCCCCATGGAATGGGGGGACTCAGGAGTC       TACCAATGTGTTATAAAGGGTAGAGACAGCTGTCATAGAATACATGTAAACCTAACTGTTTTTGAAAA       ACATTGGTGTGACACTTCCATAGGTGGTTTACCAAATTTATCAGATGAGTACAAGCAAATATTACATC       TTGGAAAAGATGATAGTCTCACATGTCATCTGCACTTCCCGAAGAGTTGTGTTTTGGGTCCAATAAAG       TGGTATAAAGACTGTAACGAGATTAAAGGGGAGCGGTTCACTGTTTTGGAAACCAGGCTTTTGGTGAG       CAATGTCTCGGCAGAGGACAGAGGGAACTACGCGTGTCAAGCCATACTGACACACTCAGGGAAGCAGT       ACGAGGTTTTAAATGGCATCACTGTGAGCATTAGTACCACTCTGATTGTGGACTGCAATGTAACAGAC       ACCAAGGATAATACAAATCTACGATGCTGGAGAGTCAATAACACTTTGGTGGATGATTACTATGATGA       ATCCAAACGAATCAGAGAAGGGGTGGAAACCCATGTCTCTTTTCGGGAACATAATTTGTACACAGTAA       ACATCACCTTCTTGGAAGTGAAAATGGAAGATTATGGCCTTCCTTTCATGTGCCACGCTGGAGTGTCA       ACAGCATACATTATATTACAGCTCCCAGCTCCGGATTTTCGAGCTTACTTGATAGGAGGGCTTATCGC       CTTGGTGGCTGTGGCTGTGTCTGTTGTGTACATATACAACATTTTTAAGATCGACATTGTTCTTTGGT       ATCGAAGTGCCTTCCATTCTACAGAGACCATAGTAGATGGGAAGCTGTATGACGCCTATGTCTTATAC       CCCAAGCCCCACAAGGAAAGCCAGAGGCATGCCGTGGATGCCCTGGTGTTGAATATCCTGCCCGAGGT       GTTGGAGAGACAATGTGGATATAAGTTGTTTATATTCGGCAGAGATGAATTCCCTGGACAAGCCGTGG       CCAATGTCATCGATGAAAACGTTAAGCTGTGCAGGAGGCTGATTGTCATTGTGGTCCCCGAATCGCTG       GGCTTTGGCCTGTTGAAGAACCTGTCAGAAGAACAAATCGCGGTCTACAGTGCCCTGATCCAGGACGG       GATGAAGGTTATTCTCGTTGAGCTGGAGAAAATCGAGGACTACACAGTCATGCCAGAGTCAATTCAGT       ACATCAAACAGAAGCATGGTGCCATCCGGTGGCATGGGGACTTCACGGAGCAGTCACAGTGTATGAAG       ACCAAGTTTTGGAAGACAGTGAGATACCACATGCCACCCAGAAGGTGTCGGCCGTTTCCTCCGGTCCA       GCTGCTGCAGCACACACCTTGCTGCCGCACCGCAGGCCCAGAACTAGGCTCAAGAAGAAAGAAGTGTA       CTCTCACGACTGGC TAA   GACTTGCTGGACTGACACCTATGGCTGGAAGATGACTTGTTTTGCTCCATG           TCTCCTCATTCCTACACCTATTTTCTGCTGCAGGATGAGGCTAGGGTTAGCATTCTAGA                                                   NOV5f, CG50389-03   SEQ ID NO: 76   550 aa   MW at 62620.8kD               Protein Sequence                     MWSLLLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKI           IQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQIL       HLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGK       QYEVLNGITVSISTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYT       VNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFRAYLIGGLIALVAVAVSVVYIYNIFKIDIVL       WYRSAFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALVLNILPEVLERQCGYKLFIFGRDEFPGQA       VANVIDENVKLCRRLIVIVVPESLGFGLLKNLSEEQIAVYSALIQDGMKVILVELEKIEDYTVMPESI       QYIKQKHGAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRRCRPFPPVQLLQHTPCCRTAGPELGSRRKK       CTLTTG                                             NOV5g, CG50389-05   SEQ ID NO: 77   1829 bp               DNA Sequence   ORF Start: ATG at 42   ORF Stop: TAA at 1767                       GGTCCTGCGCGCTTCAATCCTGCAGGCAGCCCGGTTTGGGG   ATG TGGTCCTTGCAGCTCTGCGGGTTG           TCCATCGCCCTTCCACTGTCTGTCACAGCAGATGGATGCAAGGACATTTTTATGAAAAATGAGATACT       TTCAGCAAGCCAGCCTTTTGCTTTTAATTGTACATTCCCTCCCATAACATCTGGGGAGGTCAGTGTAA       CATGGTATAAAAATTCTAGCAAAATCCCAGTGTCCAAAATCATACAGTCTAGAATTCACCAGGACGAG       ACTTGGATTTTGTTTCTCCCCATGGAATGGGGGGACTCAGGAGTCTACCAATGTGTTATAAAGGGTAG       AGACAGCTGTCATAGAATACATGTAAACCTAACTGTTTTTGAAAAACATTGGTGTGACACTTCCATAG       GTGGTTTACCAAATTTATCAGATGAGTACAAGCAAATATTACATCTTGGAAAAGATGATAGTCTCACA       TGTCATCTGCACTTCCCGAAGAGTTGTGTTTTGGGTCCAATAAAGTGGTATAAGGACTGTAACGAGAT       TAAAGGGGAGCGGTTCACTGTTTTGGAAACCAGGCTTTTGGTGAGCAATGTCTCGGCAGAGGACAGAG       GGAACTACGCGTGTCAAGCCATACTGACACACTCAGGGAAGCAGTACGAGGTTTTAAATGGCATCACT       GTGAGCATTACAGAAAGAGCTGGATATGGAGGAAGTGTCCCTAAATCATTTATCCAAAAAAATCATTC       AATTGAAGTACAGCTTGGTACCACTCTGATTGTGGACTGCAATGTAACAGACACCAAGGATAATACAA       ATCTACGATGCTGGAGAGTCAATAACACTTTGGTGGATGATTACTATGATGAATCCAAACGAATCAGA       GAAGGGGTGGAAACCCATGTCTCTTTTCGGGAACATAATTTGTACACAGTAAACATCACCTTCTTGGA       AGTGAAAATGGAAGATTATGGCCTTCCTTTCATGTGCCACGCTGGAGTGTCCACAGCATACATTATAT       TACAGCTCCCAGCTCCGGATTTTCGAGCTTACTTGATAGGAGGGCTTATCGCCTTGGTGGCTGTGGCT       GTGTCTGTTGTGTACATATACAACATTTTTAAGATCGACATTGTTCTTTGGTACCGAAGTGCCTTCCA       TTCTACAGAGACCATAGTAGATGGGAAGCTGTATGACGCCTATGTCTTATACCCCAAGCCCCACAAGG       AAAGCCAGAGGCATGCCGTGGATGCCCTGGTGTTGAATATCCTGCCCGAGGTGTTGGAGAGACAATGT       GGATATAAGTTGTTTATATTCGGCAGAGATGAATTCCCTGGACAAGCCGTGGCCAATGTCATCGATGA       AAACGTTAAGCTGTGCAGGAGGCTGATTGTCATTGTGGTCCCCGAATCGCTGGGCTTTGGCCTGTTGA       AGAACCTGTCAGAAGAACAAATCGCGGTCTACAGTGCCCTGATCCAGGACGGGATGAAGGTTATTCTC       ATTGAGCTGGAGAAAATCGAGGACTACACAGTCATGCCAGAGTCAATTCAGTACATCAAACAGAAGCA       TGGTGCCATCCGGTGGCATGGGGACTTCACGGAGCAGTCACAGTGTATGAAGACCAAGTTTTGGAAGA       CAGTGAGATACCACATGCCGCCCAGAAGGTGTCGGCCGTTTCCTCCGGTCCAGCTGCCGCAGCACACA       CCTTGCTACCGCACCGCAGGCCCAGAACTAGGCTCAAGAAGAAAGAAGTGTACTCTCACGACTGGC TA           A   GACTTGCTGGACTGACACCTATGGCTGGAAGATGACTTGTTTTGCTCCATGTCTCCTCAT                                                   NOV5g, CG50389-05   SEQ ID NO: 78   575 aa   MW at 65402.8kD               Protein Sequence                     MWSLQLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKI           IQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQIL       HLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGK       QYEVLNGITVSITERAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDD       YYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFRAYLIG       GLIALVAVAVSVVYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALVLNI       LPEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIVIVVPESLGFGLLKNLSEEQIAVYSAL       IQDGMKVILIELEKIEDYTVMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRRCRPF       PPVQLPQHTPCYRTAGPELGSRRKKCTLTTG                                     NOV5h, SNP13382464 of   SEQ ID NO: 79   1897 bp           CG50389-04, DNA Sequence   ORF Start: ATG at 51   ORF Stop: TAA at 1785           SNP Pos: 1160   SNP Change: T to C                       GAATTCCGCCCGCCCACGGCGGCGGGGAAATACCTAGGCATGGAAGTGGC   ATG ACAGGGCTCGTGTCC           CTGTCATATTTTCCACTCTCCACGAGGTCCTGCGCGCTTCAATCCTGCAGGCAGCCCGGTTTGGGGAT       GTGGTCCTTGCTGCTCTGCGGGTTGTCCATCGCCCTTCCACTGTCTGTCACAGCAGATGGATGCAAGG       ACATTTTTATGAAAAATGAGATACTTTCAGCAAGCCAGCCTTTTGCTTTTAATTGTACATTCCCTCCC       ATAACATCTGGGGAAGTCAGTGTAACATGGTATAAAAATTCTAGCAAAATCCCAGTGTCCAAAATCAT       ACAGTCTAGAATTCACCAGGACGAGACTTGGATTTTGTTTCTCCCCATGGAJJGGGGGGACTCAGGAG       TCTACCAATGTGTTATAAAGGGTAGAGACAGCTGTCATAGAATACATGTAAACCTAACTGTTTTTGAA       AAACATTGGTGTGACACTTCCATAGGTGGTTTACCAAATTTATCAGATGAGTACAAGCAAATATTACA       TCTTGGAAAAGATGATAGTCTCACATGTCATCTGCACTTCCCGAAGAGTTGTGTTTTGGGTCCAATAA       AGTGGTATAAAGACTGTAACGAGATTAAAGGGGAGCGGTTCACTGTTTTGGAAACCAGGCTTTTGGTG       AGCAATGTCTCGGCAGAGGACAGAGGGAACTACGCGTGTCAAGCCATACTGACACACTCAGGGAAGCA       GTACGAGGTTTTAAATGGCATCACTGTGAGCATTAGTACCACTCTGATTGTGGACTGCAATGTAACAG       ACACCAAGGATAATACAAATCTACGATGCTGGAGAGTCAATAACACTTTGGTGGATGATTACTATGAT       GAATCCAAACGAATCAGAGAAGGGGTGGAAACCCATGTCTCTTTTCGGGAACATAATTTGTACACAGT       AAACATCACCTTCTTGGAAGTGAAAATGGAAGATTATGGCCTTCCTTTCATGTGCCACGCTGGAGTGT       CAACAGCATACATTATATTACAGCTCCCAGCTCCGGATTTTCGAGCTTACTTGATAGGAGGGCTTATC       GCCTTGGTGGCTGTGGCTGTGTCTGTTGTGTACATATACAACATTTTTAAGATCGACATTGTTCTTTG       GTA   C   CGAAGTGCCTTCCATTCTACAGAGACCATAGTAGATGGGAAGCTGTATGACGCCTATGTCTTAT       ACCCCAAGCCCCACAAGGAAAGCCAGAGGCATGCCGTGGATGCCCTGGTGTTGAATATCCTGCCCGAG       GTGTTGGAGAGACAATGTGGATATAAGTTGTTTATATTCGGCAGAGATGAATTCCCTGGACAAGCCGT       GGCCAATGTCATCGATGAAAACGTTAAGCTGTGCAGGAGGCTGATTGTCATTGTGGTCCCCGAATCGC       TGGGCTTTGGCCTGTTGAAGAACCTGTCAGAAGAACAAATCGCGGTCTACAGTGCCCTGATCCAGGAC       GGGATGAAGGTTATTCTCGTTGAGCTGGAGAAAATCGAGGACTACACAGTCATGCCAGAGTCAATTCA       GTACATCAAACAGAAGCATGGTGCCATCCGGTGGCATGGGGACTTCACGGAGCAGTCACAGTGTATGA       AGACCAAGTTTTGGAAGACAGTGAGATACCACATGCCACCCAGAAGGTGTCGGCCGTTTCCTCCGGTC       CAGCTGCTGCAGCACACACCTTGCTGCCGCACCGCAGGCCCAGAACTAGGCTCAAGAAGAAAGAAGTG       TACTCTCACGACTGGC TAA   GACTTGCTGGACTGACACCTATGGCTGGAAGATGACTTGTTTTGCTCCA           TGTCTCCTCATTCCTACACCTATTTTCTGCTGCAGGATGAGGCTAGGGTTAGCATTCTAGA                                           NOV5h, SNP13382464 of   SEQ ID NO: 80   1578 aa   MW at 65576.2kD           CG50389-04, Protein   SNP Pos: 370       SNP Change: Tyr to Tyr       Sequence                     MTGLVSLSYFPLSTRSCALQSCRQPGLGMWSLLLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAF           NCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHV       NLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVL       ETRLLVSNVSAEDRGNYACQATLTHSGKQYEVLNGITVSISTTLIVDCNVTDTKDNTNLRCWRVNNTL       VDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFPAY       LIGGLIALVAVAVSVVYIYNIFKIDIVLW   Y   RSAFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALV       LNILPEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIVIVVPESLGFGLLKNLSEEQIAVY       SALIQDGMKSIILVELEKIEDYTVMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRR       RPFPPVQLLQHTPCCRTAGPELGSRRKKCTLTTG                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 5B.  
               TABLE 5B                       Comparison of the NOV5 protein sequences.                                        NOV5a ------------------------------------------------------------           NOV5b ------------------------------------------------------------       NOV5c -----------------------------------------------GSDGCKDIFMKNE       NOV5d ------------------------------------------------------------       NOV5e ------------------------------------------------------------       NOV5f ------------------------------MWSLLLCGLSIALPLSVTADGCKDIFMKNE       NOV5g MWSLQLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNS               NOV5a ------------------------------------------------------------       NOV5b ------------------------------------------------------------       NOV5c ILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPMEWGDS       NOV5d ------------------------------------------------------------       NOV5e ------------------------------------------------------------       NOV5f ILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPMEWGDS       NOV5g SKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDT               NOV5a -------------------------------MTGLVSLS---------------------       NOV5b -------------------------------MGGLRSLP---------------------       NOV5c GVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHF       NOV5d -------------------------------MTGLVSLS---------------------       NOV5e -------------------------------MGGLRSLP---------------------       NOV5f GVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHF       NOV5g SIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPI---------------------               NOV5a ---------YFPLSTRSCALQ--SCRQPGLGMWSLLLCGLSIALPLSVTADGCKDIFMKN       NOV5b ---------MCYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLN       NOV5c PKSCVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLN       NOV5d ---------YFPLSTRSCALQ--SCRQPGLGMWSLLLCGLSIALPLSVTADGCKDIFMKN       NOV5e ---------MCYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLN       NOV5f PKSCVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLN       NOV5g ---------KWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLN               NOV5a EILSASQP--------------------------FAFNCTFPPITSGEVSVTWYKNSSKI       NOV5b GITVSITERAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLV       NOV5c GITVSIST-------------------------TLIVDCNVTDTKDNTNLRCWRVNNTLV       NOV5d EILSASQP--------------------------FAFNCTFPPITSGEVSVTWYKNSSKI       N0V5e GITVSITERAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLV       NOV5f GITVSIST-------------------------TLIVDCNVTDTKDNTNLRCWRVNNTLV       NOV5g GITVSITEPAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLV               NOV5a PVSKIIQSRIHQ---------DE---T-WILFLPMEWGDSGVYQCVIKGRDSCHRIHVNL       NOV5b DDYYDESKRIREGVETHASFREHNLYTVNITFLEVKMEDYGLPFVCHAGVSTAYIILQLP       NOV5c DDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLP       NOV5d PVSKIIQSRIHQ---------DE---T-WILFLPMEWGDSGVYQCVIK---TVTRLKGSG       NOV5e DDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLP       NOV5f DDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLP       NOV5g DDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLP               NOV5a TVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKG       NOV5b APDFRAYLIGGLIALVAVAVSVVYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYP       NOV5c APDFRAYLE---------------------------------------------------       NOV5d SLFWKPGFW---------------------------------------------------       NOV5e APDFRAYLIGGLIALVAVAVSVVYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYP       NOV5f APDFRAYLIGGLIALVAVAVSVVYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYP       NOV5g APDFRAYLIGGLIALVAVAVSVVYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYP               NOV5a ERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSISTTLIVDCNVTDTK       NOV5b KPHKESQRHAVDALVLNILPEVLERQCGYKLFIFGRDEFLGQAVANVIDENVKLCRRLIV       NOV5c ------------------------------------------------------------       NOV5d ------------------------------------------------------------       NOV5e KPHKESQRHAVDALVLNILPEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIV       NOV5f KPHKESQRHAVDALVLNILPEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIV       NOV5g KPHKESQRHAVDALVLNILPEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIV               NOV5a DNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFM       NOV5b IVVPESLGFGLLKNLSEEQIAVYSALIQDGMKVILIELEKIEDYTVMPESIQYIKQKHGA       NOV5c ------------------------------------------------------------       NOV5d ------------------------------------------------------------       NOV5e IVVPESLGFGLLKNLSEEQIAVYSALIQDGMKVILIELEKIEDYTVMPESIQYIKQKHGA       NOV5f IVVPESLGFGLLKNLSEEQIAVYSALIQDGMKVILVELEKIEDYTVMPESIQYIKQKHGA       NOV5g IVVPESLGFGLLKNLSEEQIAVYSALIQDGMKVILIELEKIEDYTVMPESIQYIKQKHGA               NOV5a CHAGVSTAYIILQLPAPDFRAYLIGGLIALVAVAVSVVYIYNIFKIDIVLWYRSAFHSTE       NOV5b IRWHGDFTEQSQCMKTKFWKTVRYHMPPRRCRPFPPVQLPQHTPCYRTAGPELGSRRKKC       NOV5c ------------------------------------------------------------       NOV5d ------------------------------------------------------------       NOV5e IRWHGDFTEQSQCMKTKFWKTVRYHMPPRRCRPFLRSTCRSTHLCTAPQAQN--------       N0V5f IRWHGDFTEQSQCMKTKFWKTVRYHMPPRRCRPFPPVQLLQHTPCCRTAGPELGSRRKKC       NOV5g IRWHGDFTEQSQCMKTKFWKTVRYHMPPRRCRPFPPVQLPQHTPCYRTAGPELGSRRKKC               NOV5a TIVDGKLYDAYVLYPKPHKESQRHAVDALVLNILPEVLERQCGYKLFIFGRDEFPGQAVA       NOV5b TLTTG-------------------------------------------------------       NOV5c ------------------------------------------------------------       NOV5d ------------------------------------------------------------       NOV5e ------------------------------------------------------------       NOV5f TLTTG-------------------------------------------------------       NOV5g TLTTG-------------------------------------------------------               NOV5a NVIDENVKLCRRLIVIVVPESLGFGLLKNLSEEQIAVYSALIQDGMKVILVELEKIEDYT       NOV5b ------------------------------------------------------------       NOV5c ------------------------------------------------------------       NOV5d ------------------------------------------------------------       NOV5e ------------------------------------------------------------       NOV5f ------------------------------------------------------------       NOV5g ------------------------------------------------------------               NOV5a VMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRRCRPFPPVQLLQHTPC       NOV5b ------------------------------------------------------------       NOV5c ------------------------------------------------------------       NOV5d ------------------------------------------------------------       NOV5e ------------------------------------------------------------       NOV5f ------------------------------------------------------------       NOV5g ------------------------------------------------------------               NOV5a CRTAGPELGSRRKKCTLTTG       NOV5b --------------------       NOV5c --------------------       NOV5d --------------------       NOV5e --------------------       NOV5f --------------------       NOV5g --------------------               NOV5a (SEQ ID NO: 66)       NOV5b (SEQ ID NO: 68)       NOV5c (SEQ ID NO: 70)       NOV5d (SEQ ID NO: 72)       NOV5e (SEQ ID NO: 74)       NOV5f (SEQ ID NO: 76)       NOV5g (SEQ ID NO: 78)                  
 
      Further analysis of the NOV5a protein yielded the following properties shown in Table 5C.  
               TABLE 5C                       Protein Sequence Properties NOV5a                                        SignalP analysis:   Cleavage site between residues 48 and 49       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 0; pos. chg 0; neg. chg 0           H-region:   length 14; peak value 7.84           PSG score:   3.44                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 0.58           possible cleavage site: between 40 and 41                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 40)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 41           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 342-358               −9.39                             PERIPHERAL   Likelihood = 0.58 (at 473)                         ALOM score: −9.39 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 20           Charge difference: −1.0 C(1.0)-N(2.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 1a (cytoplasmic tail 359 to 578)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   2   Hyd Moment(75):   1.16           Hyd Moment(95):   1.99   G content:   4           D/E content:   1   S/T content:   11                         Score: −2.92       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 33 CRQ|PG                 NUCDISC: discrimination of nuclear localization signals                         pat4: RRKK (5) at 569           pat7: PPRRCRP (4) at 540           pat7: PRRCRPF (5) at 541           bipartite: none           content of basic residues: 10.6%           NLS Score: 0.62       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: found                         LL at 464           LL at 552                 checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 94.1       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         55.6%: endoplasmic reticulum           22.2%: Golgi           11.1%: plasma membrane           11.1%: extracellular, including cell wall                 &gt;&gt; prediction for CG50389-04 is end (k = 9)                  
 
      A search of the NOV5a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 5D.  
               TABLE 5D                          Geneseq Results for NOV5a                                         NOV5a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length [Patent #,   Match   the Matched   Expect       Identifier   Date]   Residues   Region   Value                                             ABG69605   Human NOV6c protein -  Homo     1 . . . 578   578/578   (100%)   0.0             sapiens , 578 aa. [WO200250277-A2,   1 . . . 578   578/578   (100%)           27-JUN-2002]       ABG69604   Human NOV6b protein -  Homo     29 . . . 578    550/550   (100%)   0.0             sapiens , 550 aa. [WO200250277-A2,   1 . . . 550   550/550   (100%)           27-JUN-2002]       AAE16577   Human interleukin-1 receptor DNAX   29 . . . 547    517/544   (95%)   0.0           designation 6 (IL-1RD6) protein -  Homo     1 . . . 544   519/544   (95%)             sapiens , 562 aa. [US6326472-B1, 04-           DEC-2001]       AAE03538   Human Interleukin-1 Type 3 receptor   29 . . . 547    517/544   (95%)   0.0           (IL-1-3R) -  Homo sapiens , 562 aa.   1 . . . 544   519/544   (95%)           [US6239268-B1, 29-MAY-2001]       AAE06664   Human interleukin-1R related protein 2   29 . . . 547    517/544   (95%)   0.0           (IL-1R6) -  Homo sapiens , 562 aa.   1 . . . 544   519/544   (95%)           [WO200157219-A2, 09-AUG-2001]                  
 
      In a BLAST search of public sequence databases, the NOV5a protein was found to have homology to the proteins shown in the BLASTP data in Table 5E.  
               TABLE 5E                          Public BLASTP Results for NOV5a                                         NOV5a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q9HB29   Interleukin 1 receptor-like 2 precursor   29 . . . 578   549/575 (95%)   0.0           (IL-1Rrp2) (Interleukin-1 receptor    1 . . . 575   550/575 (95%)           related protein 2) (IL1R-rp2) -  Homo               sapiens  (Human), 575 aa.       CAC60374   Sequence 12 from Patent WO0157219   29 . . . 547   517/544 (95%)   0.0           - unidentified, 562 aa.    1 . . . 544   519/544 (95%)       Q62929   Interleukin 1 receptor-like 2 precursor   27 . . . 557   358/557 (64%)   0.0           (Interleukin-1 receptor- related protein    1 . . . 557   429/557 (76%)           2) (IL1R-rp2) -  Rattus norvegicus  (Rat),           561 aa.       Q9ERS7   Interleukin 1 receptor-like 2 precursor   27 . . . 578   364/578 (62%)   0.0           (IL-1Rrp2) -  Mus musculus  (Mouse),    1 . . . 570   432/578 (73%)           574 aa.       P14778   Interleukin-1 receptor, type I precursor   33 . . . 553   224/560 (40%)   e−101           (IL-1R-1) (IL-1R-alpha) (P80) (Antigen    7 . . . 552   314/560 (56%)           CD121a) -  Homo sapiens  (Human), 569           aa.                  
 
      PFam analysis predicts that the NOV5a protein contains the domains shown in the Table 5F.  
               TABLE 5F                          Domain Analysis of NOV5a                                             Identities/                       Similarities           Pfam   NOV5a Match   for the   Expect           Domain   Region   Matched Region   Value                                                     ig    63 . . . 125   11/64   (17%)   0.015                   47/64   (73%)           ig   167 . . . 225   13/60   (22%)   0.9                   41/60   (68%)           TIR   388 . . . 538   46/153   (30%)   2.8e−52                   136/153   (89%)                      
 
     Example 6.  
      The NOV6 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 6A.  
               TABLE 6A                       NOV6 Sequence Analysis                                                        NOV6a, CG50391-08   SEQ ID NO: 81   2268 bp               DNA Sequence   ORF Start: ATG at 206   ORF Stop: TGA at 1565                       CTCTGACTGCTCCTATTGAGCTGTCTGCTCGCTGTGCCCGCTGTGCCTGCTGTGCCCGCGCTGTCGCC               GCTGCTACCGCGTCTACTGGACGCGGGAGACGCCAGCGAGCTGGTGATTGGAGCCCTGCGGAGAGCTC           AAGCGCCCAGCTCTGCCCGAGGAGCCCAGGCTGCCCCGTGAGTCCCATAGTTGCTGCAGGAGTGGAGC           C   ATG AGCTGCGTCCTGGGTGGTGTCATCCCCTTGGGGCTGCTGTTCCTGGTCTGCGGATCCCAAGGCT       ACCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCAGCAAJJACCAGCACAACGAGTCTCACTCC       CGGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAGATCCTCATGCTGCACAACAAGCTTCGGGG       CCAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGACCTGGGATGACGAACTGGAGAAGTCTGCTG       CAGCGTGGGCCAGTCAGTGCATCTGGGAGCACGGGCCCACCAGTCTGCTGGTGTCCATCGGGCAGAAC       CTGGGCGCTCACTGGGGCAGAATAGTTTGGGTCACCACCAACAAGATCGGTTGTGCTGTGAACACCTG       CCGGAAGATGACTGTCTGGGGAGAAGTTTGGGAGAACGCGGTCTACTTTGTCTGCAATTATTCTCCAA       AGGGGAACTGGATTGGAGAAGCCCCCTACAAGAATGGCCGGCCCTGCTCTGAGTGCCCACCCAGCTAT       GGAGGCAGCTGCAGGAACAACTTGTGTTACCGAGAAGAAACCTACACTCCAAAACCTGAAACGGACGA       GATGAATGAGGTGGAAACGGCTCCCATTCCTGAAGAAAACCATGTTTGGCTCCAACCGAGGGTGATGA       GACCCACCAAGCCCAAGAAAACCTCTGCGGTCAACTACATGACCCAAGTCGTCAGATGTGACACCAAG       ATGAAGGACAGGTGCAAAGGGTCCACGTGTAACAGGTACCAGTGCCCAGCAGGCTGCCTGAACCACAA       GGCGAAGATCTTTGGAAGTCTGTTCTATGAAAGCTCGTCTAGCATATGCCGCGCCGCCATCCACTACG       GGATCCTGGATGACAAGGGAGGCCTGGTGGATATCACCAGGAACGGGAAGGTCCCCTTCTTCGTGAAG       TCTGAGAGACACGGCGTGCAGTCCCTCAGCAAATACAAACCTTCCAGCTCATTCATGGTGTCAAAAGT       GAAAGTGCAGGATTTGGACTGCTACACGACCGTTGCTCAGCTGTGCCCGTTTGAAAAGCCAGCAACTC       ACTGCCCAAGAATCCATTGTCCGGCACACTGCAAAGACGAACCTTCCTACTGGGCTCCGGTGTTTGGA       ACCAACATCTATGCAGATACCTCAAGCATCTGCAAGACAGCCGTGCACGCGGGACTCATCAGCAACGA       GAGTGGGGGTGACGTGGACGTGATGCCCGTGGATAAAAAGAAGACCTACGTGGGCTCGCTCAGGAATG       GAGTTCAGTCTGAAAGCCTGGGGACTCCTCGGGATGGAAAGGCCTTCCGGATCTTTGCTGTCAGGCAG         TGA   ATTTCCAGCACCAGGGGAGAAGGGGCGTCTTCAGGAGGGCTTCGGGGTTTTGCTTTTATTTTTAT           TTTGTCATTGCGGGGTATATGGAGAGTCAGGAAACTTCCTTTGACTGATGTTCAGTGTCCATCACTTT           GTGGCCTGTGGGTGAGGTGACATCTCATCCCCTCACTGAAGCAACAGCATCCCAAGGTGCTCAGCCGG           ACTCCCTGGTGCCTGATCCTGCTGGGGCCCGGGGGTCTCCATCTGGACGTCCTCTCTCCTTTAGAGAT           CTGAGCTGTCTCTTAAAGGGGACAGTTGCCCAAAATGTTCCTTGCTATGTGTTCTTCTGTTGGTGGAG           GAAGTTGATTTCAACCTCCCTGCCAAAAGAACAAACCATTTGAAGCTCACAATTGTGAAGCATTCACG           GCGTCGGAAGAGGCCTTTTGAGCAAGCGCCAATGAGTTTCAGGAATGAAGTAGAAGGTAGTTATTTAA           AAATAAAAAACACAGTCCGTCCCTACCAATAGAGGAAAATGGTTTTAATGTTTGCTGGTCAGACAGAC           AAATGGGCTAGAGTAAGAGGGCTGCGGGTATGAGAGACCCCGGCTCCGCCCTGGCACGTGTCCTTGCT           GGCGGCCCGCCACAGGCCCCCTTCAATGGCCGCATTCAGGATGGCTCTATACACAGCAGTGCTGGTTT           ATGTAAAGTTCAGCAGTCACTTCA                                                   NOV6a, CG50391-08   SEQ ID NO: 82   453 aa   MW at 50641.5kD               Protein Sequence                     MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRPAIPREDKEEILMLHNKLRG           QVQPQASNMEYMTWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLGAHWGRIVWVTTNKIGCAVNTC       RKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDE       MNEVETAPIPEENHVWLQPRVMRPTKPKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHK       AKIFGSLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKV       KVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVISNE       SGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ                                             NOV6b, CG50391-09   SEQ ID NO: 83   2280 bp               DNA Sequence   ORF Start: ATG at 206   ORF Stop: TGA at 1577                       CTCTGACTGCTCCTATTGAGCTGTCTGCTCGCTGTGCCCGCTGTGCCTGCTGTGCCCGCGCTGTCGCC               GCTGCTACCGCGTCTACTGGACGCGGGAGACGCCAGCGAGCTGGTGATTGGAGCCCTGCGGAGAGCTC           AAGCGCCCAGCTCTGCCCGAGGACCCCAGGCTGCCCCGTGAGTCCCATAGTTGCTGCAGGAGTGGAGC           C   ATG AGCTGCGTCCTGGGTGGTGTCATCCCCTTGGGGCTGCTGTTCCTGGTCTGCGGATCCCAAGGCT       ACCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCAGCAAATACCAGCACAACGAGTCTCACTCC       CGGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAGATCCTCATGCTGCACAACAAGCTTCGGGG       CCAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGTATCGCTCTCCGGGGTTCCATGTGCAGTCCT       GGTATGACGAGGTGAAGGACTACACCTACCCCTACCCGAGCGAGTGCAACCCCTGGTGTCCAGAGAGG       TGCTCGGGGCCTATGTGCACGCACTACACACAGATAGTTTGGGCCACCACCAACAAGATCGGTTGTGC       TGTGAACACCTGCCGGAAGATGACTGTCTGGGGAGAAGTTTGGGAGAACGCGGTCTACTTTGTCTGCA       ATTATTCTCCAAAGGGGAACTGGATTGGAGAAGCCCCCTACAAGAATGGCCGGCCCTGCTCTGAGTGC       CCACCCAGCTATGGAGGCAGCTGCAGGAACAACTTGTGTTACCGAGAAGAAACCTACACTCCAAAACC       TGAAACGGACGAGATGAATGAGGTGGAAACGGCTCCCATTCCTGAAGAAAACCATGTTTGGCTCCAAC       CGAGGGTGATGAGACCCACCAAGCCCAAGAAAACCTCTGCGGTCAACTACATGACCCAAGTCGTCAGA       TGTGACACCAAGATGAAGGACAGGTGCAAAGGGTCCACGTGTAACAGGTACCAGTGCCCAGCAGGCTG       CCTGAACCACAAGGCGAAGATCTTTGGAACTCTGTTCTATGAAAGCTCGTCTAGCATATGCCGCGCCG       CCATCCACTACGGGATCCTGGATGACAAGGGAGGCCTGGTGGATATCACCAGGAACGGGAAGGTCCCC       TTCTTCGTGAAGTCTGAGAGACACGGCGTGCAGTCCCTCAGCAAATACAAACCTTCCAGCTCATTCAT       GGTGTCAAAAGTGAAAGTGCAGGATTTGGACTGCTACACGACCGTTGCTCAGCTGTGCCCGTTTGAAA       AGCCAGCAACTCACTGCCCAAGAATCCATTGTCCGGCACACTGCAAAGACGAACCTTCCTACTGGGCT       CCGGTGTTTGGAACCAACATCTATGCAGATACCTCAAGCATCTGCAAGACAGCCGTGCACGCGGGAGT       CATCAGCAACGAGAGTGGGGGTGACGTGGACGTGATGCCCGTGGATAAAAAGAAGACCTACGTGGGCT       CGCTCAGGAATGGAGTTCAGTCTGAAAGCCTGGGGACTCCTCGGGATGGAAAGGCCTTCCGGATCTTT       GCTGTCAGGCAG TGA   ATTTCCACCACCAGGGGAGAAGGGGCGTCTTCAGGAGGGCTTCGGGGTTTTGC           TTTTATTTTTATTTTGTCATTGCGGGGTATATGGAGAGTCAGGAAACTTCCTTTGACTGATGTTCAGT           GTCCATCACTTTGTGGCCTGTGGGTGAGGTGACATCTCATCCCCTCACTGAAGCAACAGCATCCCAAG           GTGCTCAGCCGGACTCCCTGGTGCCTGATCCTGCTGGGGCCCGGGGGTCTCCATCTGGACGTCCTCTC           TCCTTTAGAGATCTGAGCTGTCTCTTAAAGGGGACAGTTGCCCAAAATGTTCCTTGCTATGTGTTCTT           CTGTTGGTGGAGGAAGTTGATTTCAACCTCCCTGCCAAAAGAACAAACCATTTGAAGCTCACAATTGT           GAAGCATTCACGGCGTCGGAAGAGGCCTTTTGAGCAAGCGCCAATGAGTTTCAGGAATGAAGTAGAAG           GTAGTTATTTAAAAATAAAAAACACAGTCCGTCCCTACCAATAGAGGAAAATGGTTTTAATGTTTGCT           GGTCAGACAGACAAATGGGCTAGAGTAAGAGGGCTGCGGGTATGAGAGACCCCGGCTCCGCCCTGGCA           CGTGTCCTTGCTGGCGGCCCGCCACAGGCCCCCTTCAATGGCCGCATTCAGGATGGCTCTATACACAG           CAGTGCTGGTTTATGTAAAGTTCAGCAGTCACTTCA                                                   NOV6b, CG50391-09   SEQ ID NO: 84   457 aa   MW at 51515.4kD               Protein Sequence                     MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRG           QVQPQASNMEYMYRSPGFHVQSWYDEVKDYTYPYPSECNPWCPERCSGPMCTHYTQIVWATTNKIGCA       VNTCRKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKP       ETDEMNEVETAPIPEENHVWLQPRVMRPTKPKKTSAVNYMTQVvRCDTKNKDRCKGSTCNRYQCPAGC       LNHKAKIFGTLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSSSFM       VSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGV       ISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ                                             NOV6c, CG50391-10   SEQ ID NO: 85   2106 bp               DNA Sequence   ORF Start: ATG at 206   ORF Stop: TGA at 1403                       CTCTGACTGCTCCTATTGAGCTGTCTGCTCGCTGTGCCCGCTGTGCCTGCTGTGCCCGCGCTGTCGCC               GCTGCTACCGCGTCTACTGGACGCGGGAGACGCCAGCGAGCTGGTGATTGGAGCCCTGCGGAGAGCTC           AAGCGCCCAGCTCTGCCCGAGGAGCCCAGGCTGCCCCGTGAGTCCCATAGTTGCTGCAGGAGTGGAGC           C   ATG AGCTGCGTCCTGGGTGGTGTCATCCCCTTGGGGCTGCTGTTCCTGGTCTGCGGATCCCAAGGCT       ACCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCAGCAAATACCAGCACAACGAGTCTCACTCC       CGGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAGATCCTCATGCTGCACAACAAGCTTCGGGG       CCAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGACCTGGGATGACGAACTGGAGAAGTCTGCTG       CAGCGTGGGCCAGTCAGTGCATCTGGGAGCACGGGCCCACCAGTCTGCTGGTGTCCATCGGGCAGAAC       CTGGGCGCTCACTGGGGCAGGGGGAACTGGATTGGAGAAGCCCCCTACAAGAATGGCCGGCCCTGCTC       TGAGTGCCCACCCAGCTATGGAGGCAGCTGCAGGAACAACTTGTGTTACCGAGAAGAAACCTACACTC       CAAAACCTGAAACGGACGAGATGAATGAGGTGGAAACGGCTCCCATTCCTGAAGAAAACCATGTTTGG       CTCCAACCGAGGGTGATGAGACCCACCAAGCCCAAGAAAACCTCTGCGGTCAACTACATGACCCAAGT       CGTCAGATGTGACACCAAGATGAAGGACAGGTGCAAAGGGTCCACGTGTAACAGGTACCAGTGCCCAG       CAGGCTGCCTGAACCACAAGGCGAAGATCTTTGGAAGTCTGTTCTATGAAAGCTCGTCTAGCATATGC       CGCGCCGCCATCCACTACGGGATCCTGGATGACAAGGGAGGCCTGGTGGATATCACCAGGAACGGGAA       GGTCCCCTTCTTCGTGAAGTCTGAGAGACACGGCGTGCAGTCCCTCGTGCAGGATTTGGACTGCTACA       CGACCGTTGCTCAGCTGTGCCCGTTTGAAAAGCCAGCAACTCACTGCCCAAGAATCCATTGTCCGGCA       CACTGCAAAGACGAACCTTCCTACTGGGCTCCGGTGTTTGGAACCAACATCTATGCAGATACCTCAAG       CATCTGCAAGACAGCCGTGCACGCGGGAGTCATCAGCAACGAGAGTGGGGGTGACGTGGACGTGATGC       CCGTGGATAAAAAGAAGACCTACGTGGGCTCGCTCAGGAATGGAGTTCAGTCTGAAAGCCTGGGGACT       CCTCGGGATGGAAAGGCCTTCCGGATCTTTGCTGTCAGGCAG TGA   ATTTCCAGCACCAGGGGAGAAGG           GGCGTCTTCAGGAGGGCTTCGGGGTTTTGCTTTTATTTTTATTTTGTCATTGCGGGGTATATGGAGAG           TCAGGAAACTTCCTTTGACTGATGTTCAGTGTCCATCACTTTGTGGCCTGTGGGTGAGGTGACATCTC           ATCCCCTCACTGAAGCAACAGCATCCCAAGGTGCTCAGCCGGACTCCCTGGTGCCTGATCCTGCTGGG           GCCCGGGGGTCTCCATCTGGACGTCCTCTCTCCTTTAGAGATCTGAGCTGTCTCTTAAAGGGGACAGT           TGCCCAAAATGTTCCTTGCTATGTGTTCTTCTGTTGGTGGAGGAAGTTGATTTCAACCTCCCTGCCAA           AAGAACAAACCATTTGAAGCTCACAATTGTGAAGCATTCACGGCGTCGGAAGAGGCCTTTTGAGCAAC           CGCCAATGAGTTTCAGGAATGAAGTAGAAGGTAGTTATTTAAAAATAAAAAACACAGTCCGTCCCTAC           CAATAGAGGAAAATGGTTTTAATGTTTGCTGGTCAGACAGACAAATGGGCTAGAGTAAGAGGGCTGCG           GGTATGAGAGACCCCGGCTCCGCCCTGGCACGTGTCCTTGCTGGCGGCCCGCCACAGGCCCCCTTCAA           TGGCCGCATTCAGGATGGCTCTATACACAGCAGTGCTGGTTTATGTAAAGTTCAGCAGTCACTTCA                                                   NOV6c, CG50391-10   SEQ ID NO: 86   399 aa   MW at 44463.2kD               Protein Sequence                     MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRPAIPREDKEEILMLHNKLRG           QVQPQASNMEYMTWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLGAHWGRGNWIGEAPYKNGRPCS       ECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPIPEENHVWLQPRVMRPTKPKKTSAVNYMTQV       VRCDTKMKDRCKGSTCNRYQCPAGCLNHKAKIFGSLFYESSSSICRAAIHYGILDDKGGLVDITRNGK       VPFFVKSERHGVQSLVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTSS       ICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ                                             NOV6d, CG50391-01   SEQ ID NO: 87   2305 bp               DNA Sequence   ORF Start: ATG at 453   ORF Stop: TGA at 1602                       CTCTGACTGCTCCTATTGAGCTGTCTGCTCGCTGTGCCCGCTGTGCCTGCTGTGCCCGCGCTGTCGCC               GCTGCTACCGCGTCTACTGGACGCGGGAGACGCCAGCGAGCTGGTGATTGGAGCCCTGCGGAGAGCTC           AAGCGCCCAGCTCTGCCCGAGGAGCCCAGGCTGCCCCGTGAGTCCCATAGTTGCTACAGGAGTGGAGC           CATGAGCTGCGTCCTGGGTGGTGTCATCCCCTTGGGGCTGCTGTTCCTGGTCCGCGGATCCCAAGGCT           ACCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCAGCAAATACCAGCACAACGAGTCTCACTCC           CGGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAGATCCTCATGCTGCACAACAAGCTTCGGGG           CCAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGACCTGGG   ATG ACGAACTGGGGCAGGTATCGC       TCTCCGGGGTTCCATGTGCAGTCCTGGTATGACGAGGTGAAGGACTACACCTACCCCTACCCGAGCGA       GTGCAACCCCTGGTGTCCAGAGAGGTGCTCGGGGCCTATGTGCACGCACTACACACAGATAGTTTGGG       CCACCACCAACAAGATCGGTTGTGCTGTGAACACCTGCCGGAAGATGACTGTCTGGGGAGAAGTTTGG       GAGAACGCGGTCTACTTTGTCTGCAATTATTCTCCAAAGGGGAACTGGATTGGAGAAGCCCCCTACAA       GAATGGCCGGCCCTGCTCTGAGTGCCCACCCAGCTATGGAGGCAGCTGCAGGAACAACTTGTGTTACC       GAGAAGAACCTACACTCCAACCTGAAACGGACGAGATGAATGAGGTGGTGGAAACGGCTCCCATTCCT       GAAGAAAACCATGTTTGGCTCCAACCGAGGGTGATGAGACCCACCAAGCCCAAGAAAACCTCTGCGGT       CAACTACATGACCCAAGTCGTCAGATGTGACACCAAGATGAAGGACAGGTGCAAAGGGTCCACGTGTA       ACAGGTACCAGTGCCCAGCAGGCTGCCTGACCACAAGGCGAGATCTTTGGAACTCTCTGTTCTATGAA       AGCTCGTCTAGCATATGCCGCGCCGCCATCCACTACGGGATCCTGGATGACAAGGGAGGCCTGGTGGA       TATCACCAGGAACGGGAAGGTCCCCTTCTTCGTGAAGTCTGAGAGACACGGCGTGCAGTCCCTCAGCA       AATACAAACCTTCCAGCTCATTCATGGTGTCAAAAGTGAAAGTGCAGGATTTGGACTGCTACACGACC       GTTGCTCAGCTGTGCCCGTTTGAAAAGCCAGCAACTCACTGCCCAAGAATCCATTGTCCGGCACACTG       CAAAGACGAACCTTCCTACTGGGCTCCGGTGTTTGGAACCAACATCTATGCAGATACCTCAAGCATCT       GCAAGACAGCCGTGCACGCGGGAGTCATCAGCAACGAGAGTGGGGGTGACGTGGACGTGATGCCCGTG       GATAAAAAGAAGACCTACGTGGGCTCGCTCAGGAATGGAGTTCAGTCTGAAAGCCTGGGGACTCCTCG       GGATGGAAAGGCCTTCCGGATCTTTGCTGTCAGGCAG TGA   ATTTCCAGCACCAGGGGAGAAGGGGCGT           CTTCAGGAGGGCTTCGGGGTTTTGCTTTTATTTTTATTTTGTCATTGCGGGGTATATGGAGAGTCAGG           AAACTTCCTTTGACTGATGTTCAGTGTCCATCACTTTGTGGCCTGTGGGTGAGGTGACATCTCATCCC           CTCACTGAAGCAACAGCATCCCAAGGTGCTCAGCCGGACTCCCTGGTGCCTGATCCTGCTGGGGCCCG           GGGGTCTCCATCTGGACGTCCTCTCTCCTTTAGAGATCTGAGCTGTCTCTTAAAGGGGACAGTTGCCC           AAAATGTTCCTTGCTATGTGTTCTTCTGTTGGTGGAGGAAGTTGATTTCAACCTCCCTGCCAAAAGAA           CAAACCATTTGAAGCTCACAATTGTGAAGCATTCACGGCGTCGGAAGAGGCCTTTTGAGCAAGCGCCA           ATGAGTTTCAGGAATGAAGTAGAAGGTAGTTATTTAAAAATAAAAAACACAGTCCGTCCCTACCAATA           GAGGAAAATGGTTTTAATGTTTGCTGGTCAGACAGACAAATGGGCTAGAGTAAGAGGGCTGCGGGTAT           GAGAGACCCCGGCTCCGCCCTGGCACGTGTCCTTGCTGGCGGCCCGCCACAGGCCCCCTTCAATGGCC           GCATTCAGGATGGCTCTATACACAGCAGTGCTGGTTTATGTAAAGTTCAGCAGTCACTTCA                                                   NOV6d, CG50391-01   SEQ ID NO: 88   383 aa   MW at 43185.7kD               ProteinSequence                     MTNWGRYRSPGFHVQSWYDEVKDYTYPYPSECNPWCPERCSGPMCTHYTQIVWATTNKIGCAVNTCRK           MTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMN       EVETAPIPEENHVWLQPRVMRPTKPKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKAK       IFGTLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKVKV       QDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVISNESG       GDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ                                             NOV6e, CG50391-02   SEQ ID NO: 89   1669 bp               DNA Sequence   ORF Start: ATG at 205   ORF Stop: TAG at 1636                       TCTGACTGCTCCTATTGAGCTGTCTGCTCGCTGTGCCCGCTGTGCCTGCTGTGCCCGCGCTGTCGCCC               CTGCTACCGCGTCTACTGGACGCGGGAGACGCCAGCGAGCTGGTGATTGGAGCCCTGCGGAGAGCTCA           AGCGCCCAGCTCTGCCCGAGGAGCCCAGGCTGCCCCGTGAGTCCCATAGTTGCTGCAGGAGTGGAGCC           ATG AGCTGCGTCCTGGGTGGTGTCATCCCCTTGGGGCTGCTGTTCCTGGTCTGCGGATCCCAAGGCTA       CCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCAGCAAATACCAGCACAACGAGTCTCACTCCC       GGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAGATCCTCATGCTGCACAACAAGCTTCGGGGC       CAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGACCTGGGATGACGAACTGGAGAAGTCTGCTGC       AGCGTGGGCCAGTCAGTGCATCTGGGAGCACGGGCCCACCGGTCTGCTGGTGTCCATCGGGCAGAACC       TGGGCGCTCACTGGGGCAGGTATCGCTCTCCGGGGTTCCATGTGCAGTCCTGGTATGACGAGGTGAAG       GACTACACCTACCCCTACCCGAGCGAGTGCAACCCCTGGTGTCCAGAGAGGTGCTCGGGGCCTATGTG       CACGCACTACACACAGATAGTTTGGGCCACCACCAACAAGATCGGTTGTGCTGTGAACACCTGCCGGA       AGATGACTGTCTGGGGAGAAGTTTGGGAGAACGCGGTCTACTTTGTCTGCAATTATTCTCCAAAGGGG       AACTGGATTGGAGAAGCCCCCTACAAGAATGGCCGGCCCTGCTCTCAGTGCCCACCCAGCTATGGAGG       CAGCTGCAGGAACAACTTGTGTTACCGAGAAGAAACCTACACTCCAAAACCTGAAACGGACGAGATGA       ATGAGGTGGAAACGGCTCCCATTCCTGAAGAAAACCATGTTTGGCTCCAACCGAGGGTGATGAGACCC       ACCAAGCCCAAGAAAACCTCTTCGGTCAACTACATGACCCAAGTCGTCTTATGTGACACCAAGATGAA       GGACAGGTGCAAAGGGTCCACGTGTAACAGGTACCAGTGCCCAGCAGGCTGCCTGAACCACAAGGCGA       AGATCTTTGGAACTCTGTTCTATGAAAGCTCGTCTAGCATATGCCGCGCCGCCATCCACTACGGGATC       CTGGATGACAAGGGAGGCCTGGTGGATATCACCAGGAACGGGAAGGTCCCCTTCTTCGTGAAGTCTGA       GAGACACGGCGTGCAGTCCCTCAGCAAATACAAACCTTCCAGCTCATTCATGGTGTCAAAAGTGAAAG       TGCAGGATTTGGACTGCTACACGACCGTTGCTCAGCTGTGCCCGTTTGAAAAGCCAGCAACTCACTGC       CCAAGAATCCATTGTCCGGCACACTGCAAAGACGAACCTTCCTACTGGGCTCCGGTGTTTGGAACCAA       CATCTATGCAGATACCTCAAGCATCTGCAAGACAGCCGTGCACGCGGGAGTCATCAGCAACGAGAGTG       GGGGTGACGTGGACGTGATGCCCGTGGATAAAAAGAAGACCTACACCTGCCCGGCAGCCGCTCGAGCC       CTA TAG   TGTAAACCGATTCGCAGCACACTGGCGCCGT                                                   NOV6e, CG50391-02   SEQ ID NO: 90   477 aa   MW at 53587.7kD               Protein Sequence                     MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRRATPREDKEEILMLHNKLRG           QVQPQASNNEYMTWDDELEKSAAAWASQCIWEHGPTGLLVSIGQNLGAHWGRYRSPGFHVQSWYDEVK       DYTYPYPSECNPWCPERCSGPMCTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFVCNYSPKG       NWIGEAPYKNGRPCSQCPPSYGGSCRNNLCYREETYTPKPETDENNEVETAPIPEENHVWLQPRVMRP       TKPKKTSSVNYMTQVVLCDTKMKDRCKGSTCNRYQCPAGCLMIKAKIFGTLFYESSSSICRAAIHYGI       LDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKVKVQDLDCYTTVAQLCPFEKPATHC       PRIHCPAHCKDEPSYWAPVFGTNTYADTSSICKTAVHAGVISNESGGDVDVMPVDKKKTYTCPAAARA       L                                             NOV6f, CG50391-03   SEQ ID NO: 91   2400 bp               DNA Sequence   ORF Start: ATG at 206   ORF Stop: TGA at 1697                       CTCTGACTGCTCCTATTGAGCTGTCTGCTCGCTGTGCCCGCTGTGCCTGCTGTGCCCGCGCTGTCGCC               GCTGCTACCGCGTCTACTGGACGCGGGAGACGCCAGCGAGCTGGTGATTGGAGCCCTGCGGAGAGCTC           AAGCGCCCAGCTCTGCCCGAGGAGCCCAGGCTGCCCCGTGAGTCCCATAGTTGCTGCAGGAGTGGAGC           C   ATG AGCTGCGTCCTGGGTGGTGTCATCCCCTTGGGGCTGCTGTTCCTGGTCCGCGGATCCCAAGGCT       ACCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCAGCAAATACCAGCACAACGAGTCTCACTCC       CGGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAGATCCTCATGCTGCACAACAAGCTTCGGGG       CCAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGACCTGGGATGACGAACTGGAGAAGTCTGCTG       CAGCGTGGGCCAGTCAGTGCATCTGGGAGCACGGGCCCACCGGTCTGCTGGTGTCCATCGGGCAGAAC       CTGGGCGCTCACTGGGGCAGGTATCGCTCTCCGGGGTTCCATGTGCAGTCCTGGTATGACGAGGTGAA       GGACTACACCTACCCCTACCCGAGCGAGTGCAACCCCTGGTGTCCAGAGAGGTGCTCGGGGCCTATGT       GCACGCACTACACACAGATAGTTTGGGCCACCACCAACAAGATCGGTTGTGCTGTGAACACCTGCCGG       AAGATGACTGTCTGGGGAGAAGTTTGGGAGAACGCGGTCTACTTTGTCTGCAATTATTCTCCAAAGGG       GAACTGGATTGGAGAAGCCCCCTACAAGAATGGCCGGCCCTGCTCTGAGTGCCCACCCAGCTATGGAG       GCAGCTGCAGGAACAACTTGTGTTACCGAGAAGAAACCTACACTCCAAAACCTGAAACGGACGAGATG       AATGAGGTGGAAACGGCTCCCATTCCTGAAGAAAACCATGTTTGGCTCCAACCGAGGGTGATGAGACC       CACCAAGCCCAAGAAAACCTCTGCGGTCAACTACATGACCCAAGTCGTCAGATGTGACACCAAGATGA       AGGACAGGTGCAAAGGGTCCACGTGTAACAGGTACCAGTGCCCAGCAGGCTGCCTGAACCACAAGGCG       AAGATCTTTGGAAGTCTGTTCTATGAAAGCTCGTCTAGCATATGCCGCGCCGCCATCCACTACGGGAT       CCTGGATGACAAGGGAGGCCTGGTGGATATCACCAGGAACGGGAAGGTCCCCTTCTTCGTGAAGTCTG       AGAGACACGGCGTGCAGTCCCTCAGCAAATACAAACCTTCCAGCTCATTCATGGTGTCAAAAGTGAAA       GTGCAGGATTTGGACTGCTACACGACCGTTGCTCAGCTGTGCCCGTTTGAAAAGCCAGCAACTCACTG       CCCAAGAATCCATTGTCCGGCACACTGCAAAGACGAACCTTCCTACTGGGCTCCGGTGTTTGGAACCA       ACATCTATGCAGATACCTCAAGCATCTGCAAGACAGCCGTGCACGCGGGAGTCATCAGCAACGAGAGT       GGGGGTGACGTGGACGTGATGCCCGTGGATAAAAAGAAGACCTACGTGGGCTCGCTCAGGAATGGAGT       TCAGTCTGAAAGCCTGGGGACTCCTCGGGATGGAAAGGCCTTCCGGATCTTTGCTGTCAGGCAG TGA   A           TTTCCAGCACCAGGGGAGAAGGGGCGTCTTCAGGAGGGCTTCGGGGTTTTGCTTTTATTTTTATTTTG           TCATTGCGGGGTATATGGAGAGTCAGGAAACTTCCTTTGACTGATGTTCAGTGTCCATCACTTTGTGG           CCTGTGGGTGAGGTGACATCTCATCCCCTCACTGAAGCAACAGCATCCCAAGGTGCTCAGCCGGACTC           CCTGGTGCCTGATCCTGCTGGGGCCCGGGGGTCTCCATCTGGACGTCCTCTCTCCTTTAGAGATCTGA           GCTGTCTCTTAAAGGGGACAGTTGCCCAAAATGTTCCTTGCTATGTGTTCTTCTGTTGGTGGAGGAAG           TTGATTTCAACCTCCCTGCCAAAAGAACAAACCATTTGAAGCTCACAATTGTGAAGCATTCACGGCGT           CGGAAGAGGCCTTTTGAGCAAGCGCCAATGAGTTTCAGGAATGAAGTAGAAGGTAGTTATTTAAAAAT           AAAAAACACAGTCCGTCCCTACCAATAGAGGAAAATGGTTTTAATGTTTGCTGGTCAGACAGACAAAT           GGGCTAGAGTAAGAGGGCTGCGGGTATGAGAGACCCCGGCTCCGCCCTGGCACGTGTCCTTGCTGGCG           GCCCGCCACAGGCCCCCTTCAATGGCCGCATTCAGGATGGCTCTATACACAGCAGTGCTGGTTTATGT           AAAGTTCAGCAGTCACTTCA                                                   NOV6f, CG50391-03   SEQ ID NO: 92   497 aa   MW at 55928.2kD               Protein Sequence                     MSCVLGGVIPLGLLFLVRGSQGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRG           QVQPQASNMEYMTWDDELEKSAAAWASQCIWEHGPTGLLVSIGQNLGAHWGRYRSPGFHVQSWYDEVK       DYTYPYPSECNPWCPERCSGPMCTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFVCNYSPKG       NWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPIPEENHVWLQPRVMRP       TKPKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKAKIFGSLFYESSSSICRAAIHYGI       LDDKGGLVDITPNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKVKVQDLDCYTTVAQLCPFEKPATHC       PRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGV       QSESLGTPRDGKAFRIFAVRQ                                             NOV6g, CG50391-04   SEQ ID NO: 93   2403 bp               DNA Sequence   ORF Start: ATG at 206   ORF Stop: TGA at 1700                       CTCTGACTGCTCCTATTGAGCTGTCTGCTCGCTGTGCCCGCTGTGCCTGCTGTGCCCGCGCTGTCGCC               GCTGCTACCGCGTCTACTGGACGCGCGAGACGCCAGCGAGCTGGTGATTGGAGCCCTGCGGAGAGCTC           AAGCGCCCAGCTCTGCCCGAGGAGCCCAGGCTGCCCCGTGAGTCCCATAGTTGCTGCAGGAGTGGAGC           C   ATG AGCTGCGTCCTGGGTGGTGTCATCCCCTTGGGGCTGCTGTTCCTGGTCCGCGGATCCCAAGGCT       ACCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCAGCAAATACCAGCACAACGAGTCTCACTCC       CGGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAGATCCTCATGCTGCACAACAAGCTTCGGGG       CCAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGACCTGGGATGACGAACTGGAGAAGTCTGCTG       CAGCGTGGGCCAGTCAGTGCATCTGGGAGCACGGGCCCACCAGTCTGCTGGTGTCCATCGGGCAGAAC       CTGGGCGCTCACTGGGGCAGGAGGTATCGCTCTCCGGGGTTCCATGTGCAGTCCTGGTATGACGAGGT       GAAGGACTACACCTACCCCTACCCGAGCGAGTGCAACCCCTGGTGTCCAGAGAGGTGCTCGGGGCCTA       TGTGCACGCACTACACACAGATAGTTTGGGCCACCACCAACAAGATCGGTTGTGCTGTGAACACCTGC       CGGAAGATGACTGTCTGGGGAGAAGTTTGGGAGAACGCGGTCTACTTTGTCTGCAATTATTCTCCAAA       GGGGAACTGGATTGGAGAAGCCCCCTACAAGAATGGCCGGCCCTGCTCTGAGTGCCCACCCAGCTATG       GAGGCAGCTGCAGGAACAACTTGTGTTACCGAGAAGAAACCTACACTCCAAAACCTGAAACGGACGAG       ATGAATGAGGTGGAAACGGCTCCCATTCCTGAAGAAAACCATGTTTGGCTCCAACCGAGGGTGATGAG       ACCCACCAAGCCCAAGAAAACCTCTGCGGTCAACTACATGACCCAAGTCGTCAGATGTGACACCAAGA       TGAAGGACAGGTGCAAAGGGTCCACGTGTAACAGGTACCAGTGCCCAGCAGGCTGCCTGAACCACAAG       GCGAAGATCTTTGGAAGTCTGTTCTATGAAAGCTCGTCTAGCATATGCCGCGCCGCCATCCACTACGG       GATCCTGGATGACAAGGGAGGCCTGGTGGATATCACCAGGAACGGGAAGGTCCCCTTCTTCGTGAAGT       CTGAGAGACACGGCGTGCAGTCCCTCAGCAAATACAAACCTTCCAGCTCATTCATGGTGTCAAAAGTG       AAAGTGCAGGATTTGGACTGCTACACGACCGTTGCTCAGCTGTGCCCGTTTGAAAAGCCAGCAACTCA       CTGCCCAAGAATCCATTGTCCGGCACACTGCAAAGACGAACCTTCCTACTGGGCTCCGGTGTTTGGAA       CCAACATCTATGCAGATACCTCAAGCATCTGCAAGACAGCCGTGCACGCGGGAGTCATCAGCAACGAG       AGTGGGGGTGACGTGGACGTGATGCCCGTGGATAAAAAGAAGACCTACGTGGGCTCGCTCAGGAATGG       AGTTCAGTCTGAAAGCCTGGGGACTCCTCGGGATGGAAAGGCCTTCCGGATCTTTGCTGTCAGGCAG T           GA   ATTTCCAGCACCAGGGGAGAAGGGGCGTCTTCAGGAGGGCTTCGGGGTTTTGCTTTTATTTTTATT           TTGTCATTGCGGGGTATATGGAGAGTCAGGAAACTTCCTTTGACTGATGTTCAGTGTCCATCACTTTG           TGGCCTGTGGGTGAGGTGACATCTCATCCCCTCACTGAAGCAACAGCATCCCAAGGTGCTCAGCCGGA           CTCCCTGGTGCCTGATCCTGCTGGGGCCCGGGGGTCTCCATCTGGACGTCCTCTCTCCTTTAGAGATC           TGAGCTGTCTCTTAAAGGGGACAGTTGCCCAAAATGTTCCTTGCTATGTGTTCTTCTGTTGGTGGAGG           AAGTTGATTTCAACCTCCCTGCCAAAAGAACAAACCATTTGAAGCTCACAATTGTGAAGCATTCACGG           CGTCGGAAGAGGCCTTTTGAGCAAGCGCCAATGAGTTTCAGGAATGAAGTAGAAGGTAGTTATTTAAA           AATAAAAAACACAGTCCGTCCCTACCAATAGAGGAAAATGGTTTTAATGTTTGCTGGTCAGACAGACA           AATGGGCTAGAGTAAGAGGGCTGCGGGTATGAGAGACCCCGGCTCCGCCCTGGCACGTGTCCTTGCTG           GCGGCCCGCCACAGGCCCCCTTCAATGGCCGCATTCAGGATGGCTCTATACACAGCAGTGCTGGTTTA           TGTAAAGTTCAGCAGTCACTTCA                                                   NOV6g, CG50391-04   SEQ ID NO: 94   498 aa   MW at 56114.4kD               Protein Sequence                     MSCVLGGVIPLGLLFLVRGSQGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRG           QVQPQASNMEYMTWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLGAHWGRRYRSPGFHVQSWYDEV       KDYTYPYPSECNPWCPERCSGPMCTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFVCNYSPK       GNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPIPEENHVWLQPRVMR       PTKPKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKAKIFGSLFYESSSSICRAAIHYG       ILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKVKVQDLDCYTTVAQLCPFEKPATH       CPRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNG       VQSESLGTPRDGKAFRIFAVRQ                                             NOV6h, CG50391-05   SEQ ID NO: 95   2412 bp               DNA Sequence   ORF Start: ATG at 206   ORF Stop: TGA at 1709                       CTCTGACTGCTCCTATTGAGCTGTCTGCTCGCTGTGCCCGCTGTGCCTGCTGTGCCCGCGCTGTCGCC               GCTGCTACCGCGTCTACTGGACGCGGGAGACGCCAGCGAGCTGGTGATTGGAGCCCTGCGGAGAGCTC           AAGCGCCCAGCTCTGCCCGAGGAGCCCAGGCTGCCCCGTGAGTCCCATAGTTGCTGCAGGAGTGGAGC           C   ATG AGCTGCGTCCTGGGTGGTGTCATCCCCTTGGGGCTGCTGTTCCTGGTCCGCGGATCCCAAGGCT       ACCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCAGCAAATACCAGCACAACGAGTCTCACTCC       CGGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAGATCCTCATGCTGCACAACAAGCTTCGGGG       CCAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGACCTGGGATGACGAACTGGAGAAGTCTGCTG       CAGCGTGGGCCAGTCAGTGCATCTGGGAGCACGGGCCCACCGGTCTGCTGGTGTCCATCGGGCAGAAC       CTGGGCGCTCACTGGGGCAGGTATCGCTCTCCGGGGTTCCATGTGCAGTCCTGGTATGACGAGGTGAA       GGACTACACCTACCCCTACCCGAGCGAGTGCAACCCCTGGTGTCCAGAGAGGTGCTCGGGGCCCATGT       GCACGCACTACACACAGGTAACTCAGATAGTTTGGGCCACCACCAACAAGATCGGTTGTGCTGTGAAC       ACCTGCCGGAAGATGACTGTCTGGGGAGAAGTTTGGGAGAACGCGGTCTACTTTGTCTGCAATTATTC       TCCAAAGAGGGGGAACTGGATTGGAGAAGCCCCCTACAAGAATGGCCGGCCCTGCTCTGAGTGCCCAC       CCAGCTATGGAGGCAGCTGCAGGAACAACTTGTGTTACCGAGAAGAAACCTACACTCCAAAACCTGAA       ACGGACGAGATGAATGAGGTGGAAACGGCTCCCATTCCTGAAGAAAACCATGTTTGGCTCCAACCGAG       GGTGATGAGACCCACCAAGCCCAAGAAAACCTCTGCGGTCAACTACATGACCCAAGTCGTCAGATGTG       ACACCAAGATGAAGGACAGGTGCAAAGGGTCCACGTGTAACAGGTACCAGTGCCCAGCAGGCTGCCTG       AACCACAAGGCGAAGATCTTTGGAAGTCTGTTCTATGAAAGCTCGTCTAGCATATGCCGCGCCGCCAT       CCACTACGGGATCCTGGATGACAAGGGAGGCCTGGTGGATATCACCAGGAACGGGAAGGTCCCCTTCT       TCGTGAAGTCTGAGAGACACGGCGTGCAGTCCCTCAGCAAATACAAACCTTCCAGCTCATTCATGGTG       TCAAAAGTGAAAGTGCAGGATTTGGACTGCTACACGACCGTTGCTCAGCTGTGCCCGTTTGAAAAGCC       AGCAACTCACTGCCCAAGAATCCATTGTCCGGCACACTGCAAAGACGAACCTTCCTACTGGGCTCCGG       TGTTTGGAACCAACATCTATGCAGATACCTCAAGCATCTGCAAGACAGCCGTGCACGCGGGAGTCATC       AGCAACGAGAGTGGGGGTGACGTGGACGTGATGCCCGTGGATAAAAAGAAGACCTACGTGGGCTCGCT       CAGGAATGGAGTTCAGTCTGAAAGCCTGGGGACTCCTCGGGATGGAAAGGCCTTCCGGATCTTTGCTG       TCAGGCAG TGA   ATTTCCAGCACCAGGGGAGAAGGGGCGTCTTCAGGAGGGCTTCGGGGTTTTGCTTTT           ATTTTTATTTTGTCATTGCGGGGTATATGGAGAGTCAGGAAACTTCCTTTGACTGATGTTCAGTGTCC           ATCACTTTGTGGCCTGTGGGTGAGGTGACATCTCATCCCCTCACTGAAGCAACAGCATCCCAAGGTGC           TCAGCCGGACTCCCTGGTGCCTGATCCTGCTGGGGCCCGGGGGTCTCCATCTGGACGTCCTCTCTCCT           TTAGAGATCTGAGCTGTCTCTTAAAGGGGACAGTTGCCCAAAATGTTCCTTGCTATGTGTTCTTCTGT           TGGTGGAGGAAGTTGATTTCAACCTCCCTGCCAAAAGAACAAACCATTTGAAGCTCACAATTGTGAAG           CATTCACGGCGTCGGAAGAGGCCTTTTGAGCAAGCGCCAATGAGTTTCAGGAATGAAGTAGAAGGTAG           TTATTTAAAAATAAAAAACACAGTCCGTCCCTACCAATAGAGGAAAATGGTTTTAATGTTTGCTGGTC           AGACAGACAAATGGGCTAGAGTAAGAGGGCTGCGGGTATGAGAGACCCCGGCTCCGCCCTGGCACGTG           TCCTTGCTGGCGGCCCGCCACAGGCCCCCTTCAATGGCCGCATTCAGGATGGCTCTATACACAGCAGT           GCTGGTTTATGTAAAGTTCAGCAGTCACTTCA                                                   NOV6h, CG50391-05   SEQ ID NO: 96   501 aa   MW at 56412.8kD               Protein Sequence                     MSCVLGGVIPLGLLFLVRGSQGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRG           QVQPQASNMEYMTWDDELEKSAAAWASQCIWEHGPTGLLVSIGQNLGAHWGRYRSPGFHVQSWYDEVK       DYTYPYPSECNPWCPERCSGPMCTHYTQVTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFVCNYS       PKRGNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPIPEENHVWLQPR       VMRPTKPKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKAKIFGSLFYESSSSICRAAI       HYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKVKVQDLDCYTTVAQLCPFEKP       ATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSL       RNGVQSESLGTPRDGKAFRIFAVRQ                                             NOV6i, CG50391-06   SEQ ID NO: 97   1425 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     TACCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCAGCAAATACCAGCACAACGAGTCTCACTC           CCGGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAGATCCTCATGCTGCACAACAAGCTTCGGG       GCCAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGACCTGGGATGACGAACTGGAGAAGTCTGCT       GCAGCGTGGGCCAGTCAGTGCATCTGGGAGCACGGGCCCACCGGTCTGCTGGTGTCCATCGGGCAGAA       CCTGGGCGCTCACTGGGGCAGGTATCGCTCTCCGGGGTTCCATGTGCAGTCCTGGTATGACGAGGTGA       AGGACTACACCTACCCCTACCCGAGCGAGTGCAACCCCTGGTGTCCAGAGAGGTGCTCGGGGCCTATG       TGCACGCACTACACACAGATAGTTTGGGCCACCACCAACAAGATCGGTTGTGCTGTGAACACCTGCCG       GAAGATGACTGTCTGGGGAGAAGTTTGGGAGAACGCGGTCTACTTTGTCTGCAATTATTCTCCAAAGG       GGAACTGGATTGGAGAAGCCCCCTACAAGAATGGCCGGCCCTGCTCTGAGTGCCCACCCAGCTATGGA       GGCAGCTGCAGGAACAACTTGTGTTACCGAGAAGAAACCTACACTCCAAAACCTGAAACGGACGAGAT       GAATGAGGTGGAAACGGCTCCCATTCCTGAAGAAAACCATGTTTGGCTCCAACCGAGGGTGATGAGAC       CCACCAAGCCCAAGAAAACCTCTGCGGTCAACTACATGACCCAAGTCGTCAGATGTGACACCAAGATG       AAGGACAGGTGCAAAGGGTCCACGTGTAACAGGTACCAGTGCCCAGCAGGCTGCCTGAACCACAAGGC       GAAGATCTTTGGAACTCTGTTCTATGAAAGCTCGTCTAGCATATGCCGCGCCGCCATCCACTACGGGA       TCCTGGATGACAAGGGAGGCCTGGTGGATATCACCAGGAACGGGAAGGTCCCCTTCTTCGTGAAGTCT       GAGAGACACGGCGTGCAGTCCCTCAGCAAATACAAACCTTCCAGCTCATTCATGGTGTCAAAAGTGAA       AGTGCAGGATTTGGACTGCTACACGACCGTTGCTCAGCTGTGCCCGTTTGAAAAGCCAGCAACTCACT       GCCCAAGAATCCATTGTCCGGCACACTGCAAAGACGAACCTTCCTACTGGGCTCCGGTGTTTGGAACC       AACATCTATGCAGATACCTCAAGCATCTGCAAGACAGCTGTGCACGCGGGAGTCATCAGCAACGAGAG       TGGGGGTGACGTGGACGTGATGCCCGTGGATAAAAAGAAGACCTACGTGGGCTCGCTCAGGAATGGAG       TTCAGTCTGAAAGCCTGGGGACTCCTCGGGATGGAAAGGCCTTCCGGATCTTTGCTGTCAGGCAG                                                 NOV6i, CG50391-06   SEQ ID NO: 98   475 aa   MW at 53743.6kD               Protein Sequence                     YLLPNVTLLEELLSKYQHNESHSRVRPAIPREDKEEILMLHNKLRGQVQPQASNMEYMTWDDELEKSA           AAWASQCIWEHGPTGLLVSIGQNLGAHWGRYRSPGFHVQSWYDEVKDYTYPYPSECNPWCPERCSGPM       CTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPPSYG       GSCRNNLCYREETYTPKPETDEMNEVETAPIPEENHVWLQPRVMRPTKPKKTSAVNYMTQVVRCDTKM       KDRCKGSTCNRYQCPAGCLNHKAKIFGTLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKS       ERHGVQSLSKYKPSSSFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGT       NIYADTSSICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ                                             NOV6j, CG50391-07   SEQ ID NO: 99   2272 bp               DNA Sequence   ORF Start: ATG at 216   ORF Stop: TGA at 1707                       CCCAGGGCGTCTCCGGCTGCTCCCATTGAGCTGTCTGCTCGCTGTGCCCGCTGTGCCTGCTGTGCCCG               CGCTGTCGCCGCTGCTACCGCGTCTGCTGGACGCGGGAGACGCCAGCGAGCTGGTGATTGGAGCCCTG           CGGAGAGCTCAAGCGCCCAGCTCTGCCCNAGGAGCCCAGGCTGCCCCGTGAGTCCCATAGTTGCTGCA           GGAGTGGAGCC   ATG AGCTGCGTCCTGGGTGGTGTCATCCCCTTGGGGCTGCTGTTCCTGGTCTGCGGA       TCCCAAGGCTACCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCAGCAAATACCAGCACAACGA       GTCTCACTCCCGGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAGATCCTCATGCTGCACAACA       AGCTTCGGGGCCAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGACCTGGGATGACGAACTGGAG       AAGTCTGCTGCAGCGTGGGCCAGTCAGTGCATCTGGGAGCACGGGCCCACCAGTCTGCTGGTGTCCAT       CGGGCAGAACCTGGGCGCTCACTGGGGCAGGTATCGCTCTCCGGGGTTCCATGTGCAGTCCTGGTATG       ACGAGGTGAAGGACTACACCTACCCCTACCCGAGCGAGTGCAACCCCTGGTGTCCAGAGAGGTGCTCG       GGGCCTATGTGCACGCACTACACACAGATAGTTTGGGCCACCACCAACAAGATCGGTTGTGCTGTGAA       CACCTGCCGGAAGATGACTGTCTGGGGAGAAGTTTGGGAGAACGCGGTCTACTTTGTCTGCAATTATT       CTCCAAAGGGGAACTGGATTGGAGAAGCCCCCTACAAGAATGGCCGGCCCTGCTCTGAGTGCCCACCC       AGCTATGGAGGCAGCTGCAGGAACAACTTGTGTTACCGAGAAGAAACCTACACTCCAAAACCTGAAAC       GGACGAGATGAATGAGGTGGAAACGGCTCCCATTCCTGAAGAAAACCATGTTTGGCTCCAACCGAGGG       TGATGAGACCCACCAAGCCCAAGAAAACCTCTGCGGTCAACTACATGACCCAAGTCGTCAGATGTGAC       ACCAAGATGAAGGACAGGTGCAAAGGGTCCACGTGTAACAGGTACCAGTGCCCAGCAGGCTGCCTGAA       CCACAAGGCGAAGATCTTTGGAAGTCTGTTCTATGAAAGCTCGTCTAGCATATGCCGCGCCGCCATCC       ACTACGGGATCCTGGATGACAAGGGAGGCCTGGTGGATATCACCAGGAACGGGAAGGTCCCCTTCTTC       GTGAAGTCTGAGAGACACGGCGTGCAGTCCCTCAGCAAATACAAACCTTCCAGCTCATTCATGGTGTC       AAAAGTGAAAGTGCAGGATTTGGACTGCTACACGACCGTTGCTCAGCTGTGCCCGTTTGAAAAGCCAG       CAACTCACTGCCCAAGAATCCATTGTCCGGCACACTGCAAAGACGAACCTTCCTACTGGGCTCCGGTG       TTTGGAACCAACATCTATGCAGATACCTCAAGCATCTGCAAGACAGCTGTGCACGCGGGAGTCATCAG       CAACGAGAGTGGGGGTGACGTGGACGTGATGCCCGTGGATAAAAAGAAGACCTACGTGGGCTCGCTCA       GGAATGGAGTTCAGTCTGAAAGCCTGGGGACTCCTCGGGATGGAAAGGCCTTCCGGATCTTTGCTGTC       AGGCAG TGA   ATTTCCAGCACCAGGGGAGAAGGGGCGTCTTCAGGAGGGCTTCGGGGTTTTGCTTTTAT           TTTTATTTTGTCATTGCGGGGTATATGGAGAGTCAGGAAACTTCCTTTGACTGATGTTCAGTGTCCAT           CACTTTGTGGCCTGTGGGTGAGGTGACATCTCATCCCCTCACTGAAGCAACAGCATCCCAAGGTGCTC           AGCCGGACTCCCTGGTGCCTGATCCTGCTGGGGCCTGGGGGTCTCCATCTGGACGTCCTCTCTCCTTT           AGAGATCTGAGCTGTCTCTTAAAGGGGACAGTTGCCCAAAATGTTCCTTGCTATGTGTTCTTCTGTTG           GTGGAGGAAGTTGATTTCAACCCCCCTGCCAAAAGAACAAACCATTTGAAGCTCACAATTGTGAAGCA           TTCACGGCGTCGGAAGAGGCCTTTTGAGCAAGCGCCAATGAGTTTCAGGAATGAAGTAGAAGGTAGTT           ATTTAAAAATAAAAAACACAGTCCGTCCCTACCAATAGAGGAAAATGGTTTTAATGTTTGCTGGTCAG           ACAGACAAATGGGCTAGAGTAAGAAGGC                                                   NOV6j, CG50391-07   SEQ ID NO: 100   497 aa   MW at 55905.2kD               Protein Sequence                     MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRG           QVQPQASNMEYMTWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLGAHWGRYRSPGFHVQSWYDEVK       DYTYPYPSECNPWCPERCSGPMCTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFVCNYSPKG       NWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPIPEENHVWLQPRVMRP       TKPKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKAKIFGSLFYESSSSICRAAIHYGI       LDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKVKVQDLDCYTTVAQLCPFEKPATHC       PRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGV       QSESLGTPRDGKAFRIFAVRQ                                             NOV6k, CG50391-11   SEQ ID NO: 101   1612 bp               DNA Sequence   ORF Start: ATG at 31   ORF Stop: TGA at 1522                       GAGTCCCATAGTTGCTGCAGGAGTGGAGCC   ATG AGCTGCGTCCTGGGTGGTGTCATCCCCTTGGGGCT           GCTGTTCCTGGTCTGCGGATCCCAAGGCTACCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCA       GCAAATACCAGCACAACGAGTCTCACTCCCGGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAG       ATCCTCATGCTGCACAACAAGCTTCGGGGCCAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGAC       CTGGGATGACGAACTGGAGAAGTCTGCTGCAGCGTGGGCCAGTCAGTGCATCTGGGAGCACGGGCCCA       CCAGTCTGCTGGTGTCCATCGGGCAGAACCTGGGCGCTCACTGGGGCAGGTATCGCTCTCCGGGGTTC       CATGTGCAGTCCTGGTATGACGAGGTGAAGGACTACACCTACCCCTACCCGAGCGAGTGCAACCCCTG       GTGTCCAGAGAGGTGCTCGGGGCCCATGTGCACGCACTACACACAGATAGTTTGGGCCACCACCAACA       AGATCGGTTGTGCTGTGAACACCTGCCGGAAGATGACTGTCTGGGGAGAAGTTTGGGAGAACGCGGTC       TACTTTGTCTGCAATTATTCTCCAAAGGGGAACTGGATTGGAGAAGCCCCCTACAAGAATGGCCGGCC       CTGCTCTGAGTGCCCACCCAGCTATGGAGGCAGCTGCAGGAACAACTTGTGTTACCGAGAAGAAACCT       ACACTCCAAAACCTGAAACGGACGAGATGAATGAGGTGGGAACGGCTCCCATTCCTGAAGAAAACCAT       GTTTGGCTCCAACCGAGGGTGATGAGACCCACCAAGCCCAAGAAAACCTCTGCGGTCAACTACATGAC       CCAAGTCGTCAGATGTGACACCAAGATGAAGGACAGGTGCAAAGGGTCCACGTGTAACAGGTACCAGT       GCCCAGCAGGCTGCCTGAACCACAAGGCGAAGATCTTTGGAACTCTGTTCTATGAAAGCTCGTCTAGC       ATATGCCGCGCCGCCATCCACTACGGGATCCTGGATGACAAGGGAGGCCTGGTGGATATCACCAGGAA       CGGGAAGGTCCCCTTCTTCGTGAAGTCTGAGAGACACGGCGTGCAGTCCCTCAGCAAATACAAACCTT       CCAGCTCATTCATGGTGTCAAAAGTGAAAGTGCAGGATTTGGACTGCTACACGACCGTTGCTCAGCTG       TGCCCGTTTGAAAAGCCAGCAACTCACTGCCCAAGAATCCATTGTCCGGCACACTGCAAAGACGAACC       TTCCTACTGGGCTCCGGTGTTTGGAACCAACATCTATGCAGATACCTCAAGCATCTGCAAGACAGCCG       TGCACGCGGGAGTCATCAGCAACGAGAGTGGGGGTGACGTGGACGTGATGCCCGTGGATAAAAAGAAG       ACCTACGTGGGCTCGCTCAGGAATGGAGTTCAGTCTGAAAGCCTGGGGACTCCTCGGGATGGAAAGGC       CTTCCGGATCTTTGCTGTCAGGCAG TGA   ATTTCCAGCACCAGGGGAGAAGGGGCGTCTTCAGGAGGGC           TTCGGGGTTTTGCTTTTATTTTTATTTTGTCATTGCGGGGTATAGGAG                                                   NOV6k, CG50391-11   SEQ ID NO: 102   497 aa   MW at 55847.2kD               Protein Sequence                     MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRG           QVQPQASNMEYMTWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLGAHWGRYRSPGFHVQSWYDEVK       DYTYPYPSECNPWCPERCSGPMCTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFVCNYSPKG       NWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVGTAPIPEENHVWLQPRVMRP       TKPKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKAKIFGTLFYESSSSICRAATHYGI       LDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKVKVQDLDCYTTVAQLCPFEKPATHC       PRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGV       QSESLGTPRDGKAFRIFAVRQ                                     NOV6l, SNP13376336 of   SEQ ID NO: 103   2268 bp           CG50391-08, DNA Sequence   ORF Start: ATG at 206   ORF Stop: TGA at 1565           SNP Pos: 393   SNP Change: A to G                       CTCTGACTGCTCCTATTGAGCTGTCTGCTCGCTGTGCCCGCTGTGCCTGCTGTGCCCGCGCTGTCGCC               GCTGCTACCGCGTCTACTGGACGCGGGAGACGCCAGCGAGCTGGTGATTGGAGCCCTGCGGAGAGCTC           AAGCGCCCAGCTCTGCCCGAGGAGCCCAGGCTGCCCCGTGAGTCCCATAGTTGCTGCAGGAGTGGAGC           C   ATG AGCTGCGTCCTGGGTGGTGTCATCCCCTTGGGGCTGCTGTTCCTGGTCTGCGGATCCCAAGGCT       ACCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCAGCAAATACCAGCACAACGAGTCTCACTCC       CGGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAGATCCTCATGCTGC   G   CAACAAGCTTCGGGG       CCAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGACCTGGGATGACGAACTGGAGAAGTCTGCTG       CAGCGTGGGCCAGTCAGTGCATCTGGGAGCACGGGCCCACCAGTCTGCTGGTGTCCATCGGGCAGAAC       CTGGGCGCTCACTGGGGCAGAATAGTTTGGGTCACCACCAACAAGATCGGTTGTGCTGTGAACACCTG       CCGGAAGATGACTGTCTGGGGAGAAGTTTGGGAGAACGCGGTCTACTTTGTCTGCAATTATTCTCCAA       AGGGGAACTGGATTGGAGAAGCCCCCTACAAGAATGGCCGGCCCTGCTCTGAGTGCCCACCCAGCTAT       GGAGGCAGCTGCAGGAACAACTTGTGTTACCGAGAAGAAACCTACACTCCAAAACCTGAAACGGACGA       GATGAATGAGGTGGAAACGGCTCCCATTCCTGAAGAAAACCATGTTTGGCTCCAACCGAGGGTGATGA       GACCCACCAAGCCCAAGAAAACCTCTGCGGTCAACTACATGACCCAAGTCGTCAGATGTGACACCAAG       ATGAAGGACAGGTGCAAAGGGTCCACGTGTAACAGGTACCAGTGCCCAGCAGGCTGCCTGAACCACAA       GGCGAAGATCTTTGGAAGTCTGTTCTATGAAAGCTCGTCTAGCATATGCCGCGCCGCCATCCACTACG       GGATCCTGGATGACAAGGGAGGCCTGGTGGATATCACCAGGAACGGGAAGGTCCCCTTCTTCGTGAAG       TCTGAGAGACACGGCGTGCAGTCCCTCAGCAAATACAAACCTTCCAGCTCATTCATGGTGTCAAAAGT       GAAAGTGCAGGATTTGGACTGCTACACGACCGTTGCTCAGCTGTGCCCGTTTGAAAAGCCAGCAACTC       ACTGCCCAAGAATCCATTGTCCGGCACACTGCAAAGACGAACCTTCCTACTGGGCTCCGGTGTTTGGA       ACCAACATCTATGCAGATACCTCAAGCATCTGCAAGACAGCCGTGCACGCGGGAGTCATCAGCAACGA       GAGTGGGGGTGACGTGGACGTGATGCCCGTGGATAAAAAGAAGACCTACGTGGGCTCGCTCAGGAATG       GAGTTCAGTCTGAAAGCCTGGGGACTCCTCGGGATGGAAAGGCCTTCCGGATCTTTGCTGTCAGGCAG         TGA   ATTTCCAGCACCAGGGGAGAAGGGGCGTCTTCAGGAGGGCTTCGGGGTTTTGCTTTTATTTTTAT           TTTGTCATTGCGGGGTATATGGAGAGTCAGGAAACTTCCTTTGACTGATGTTCAGTGTCCATCACTTT           GTGGCCTGTGGGTGAGGTGACATCTCATCCCCTCACTGAAGCAACAGCATCCCAAGGTGCTCAGCCGG           ACTCCCTGGTGCCTGATCCTGCTGGGGCCCGGGGGTCTCCATCTGGACGTCCTCTCTCCTTTAGAGAT           CTGAGCTGTCTCTTAAAGGGGACAGTTGCCCAAAATGTTCCTTGCTATGTGTTCTTCTGTTGGTGGAC           GAAGTTGATTTCAACCTCCCTGCCAAAAGAACAAACCATTTGAAGCTCACAATTGTGAAGCATTCACG           GCGTCGGAAGAGGCCTTTTGAGCAAGCGCCAATGAGTTTCAGGAATGAAGTAGAAGGTAGTTATTTAA           AAATAAAAAACACAGTCCGTCCCTACCAATAGAGGAAAATGGTTTTAATGTTTGCTGGTCAGACAGAC           AAATGGGCTAGAGTAAGAGGGCTGCGGGTATGAGAGACCCCGGCTCCGCCCTGGCACGTGTCCTTGCT           GGCGGCCCGCCACAGGCCCCCTTCAATGGCCGCATTCAGGATGGCTCTATACACAGCAGTGCTGGTTT           ATGTAAAGTTCAGCAGTCACTTCA                                           NOV6l, SNP13376336 of   SEQ ID NO: 104   453 aa   MW at 50660.5kD           CG50391-08, Protein   SNP Pos: 63       SNP Change: His to Arg                     MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILML   R   NKLRG           QVQPQASNMEYMTWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLGAHWGRIVWVTTNKIGCAVNTC       RKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDE       MNEVETAPIPEENHVWLQPRVMRPTKPKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHK       AKIFGSLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKV       KVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVISNE       SGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ                                     NOV6m, SNP13376335 of   SEQ ID NO: 105   2268 bp           CG50391-08, DNA Sequence   ORF Start: ATG at 206   ORF Stop: TGA at 1565           SNP Pos: 477   SNP Change: C to T                       CTCTGACTGCTCCTATTGAGCTGTCTGCTCGCTGTGCCCGCTGTGCCTGCTGTGCCCGCGCTGTCGCC             GCTGCTACCGCGTCTACTGGACGCGGGAGACGCCAGCGAGCTGGTGATTGGAGCCCTGCGGAGAGCTC       AAGCGCCCAGCTCTGCCCGAGGAGCCCAGGCTGCCCCGTGAGTCCCATAGTTGCTGCAGGAGTGGAGC         C   ATG AGCTGCGTCCTGGGTGGTGTCATCCCCTTGGGGCTGCTGTTCCTGGTCTGCGGATCCCAAGGCT       ACCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCAGCAAATACCAGCACAACGAGTCTCACTCC       CGGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAGATCCTCATGCTGCACAACAAGCTTCGGGG       CCAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGACCTGGGATGACGAACTGGAGAAGTCTGCTG           T   AGCGTGGGCCAGTCAGTGCATCTGGGAGCACGGGCCCACCAGTCTGCTGGTGTCCATCGGGCAGAAC       CTGGGCGCTCACTGGGGCAGAATAGTTTGGGTCACCACCAACAAGATCGGTTGTGCTGTGAACACCTG       CCGGAAGATGACTGTCTGGGGAGAAGTTTGGGAGAACGCGGTCTACTTTGTCTGCAATTATTCTCCAA       AGGGGAACTGGATTGGAGAAGCCCCCTACAAGAATGGCCGGCCCTGCTCTGAGTGCCCACCCAGCTAT       GGAGGCAGCTGCAGGAACAACTTGTGTTACCGAGAAGAAACCTACACTCCAAAACCTGAAACGGACGA       GATGAATGAGGTGGAAACGGCTCCCATTCCTGAAGAAAACCATGTTTGGCTCCAACCGAGGGTGATGA       GACCCACCAAGCCCAAGAAAACCTCTGCGGTCAACTACATGACCCAAGTCGTCAGATGTGACACCAAG       ATGAAGGACAGGTGCAAAGGGTCCACGTGTAACAGGTACCAGTGCCCAGCAGGCTGCCTGAACCACAA       GGCGAAGATCTTTGGAAGTCTGTTCTATGAAAGCTCGTCTAGCATATGCCGCGCCGCCATCCACTACG       GGATCCTGGATGACAAGGGAGGCCTGGTGGATATCACCAGGAACGGGAAGGTCCCCTTCTTCGTGAAG       TCTGAGAGACACGGCGTGCAGTCCCTCAGCAAATACAAACCTTCCAGCTCATTCATGGTGTCAAAAGT       GAAAGTGCAGGATTTGGACTGCTACACGACCGTTGCTCAGCTGTGCCCGTTTGAAAAGCCAGCAACTC       ACTGCCCAAGAATCCATTGTCCGGCACACTGCAAAGACGAACCTTCCTACTGGGCTCCGGTGTTTGGA       ACCAACATCTATGCAGATACCTCAAGCATCTGCAAGACAGCCGTGCACGCGGGAGTCATCAGCAACGA       GAGTGGGGGTGACGTGGACGTGATGCCCGTGGATAAAAAGAAGACCTACGTGGGCTCGCTCAGGAATG       GAGTTCAGTCTGAAAGCCTGGGGACTCCTCGGGATGGAAAGGCCTTCCGGATCTTTGCTGTCAGGCAG         TGA   ATTTCCAGCACCAGGGGAGAAGGGGCGTCTTCAGGAGGGCTTCGGGGTTTTGCTTTTATTTTTAT           TTTGTCATTGCGGGGTATATGGAGAGTCAGGAAACTTCCTTTGACTGATGTTCAGTGTCCATCACTTT           GTGGCCTGTGGGTGAGGTGACATCTCATCCCCTCACTGAAGCAACAGCATCCCAAGGTGCTCAGCCGG           ACTCCCTGGTGCCTGATCCTGCTGGGGCCCGGGGGTCTCCATCTGGACGTCCTCTCTCCTTTAGAGAT           CTGAGCTGTCTCTTAAAGGGGACAGTTGCCCAAAATGTTCCTTGCTATGTGTTCTTCTGTTGGTGGAG           GAAGTTGATTTCAACCTCCCTGCCAAAAGAACAAACCATTTGAAGCTCACAATTGTGAAGCATTCACG           GCGTCGGAAGAGGCCTTTTGAGCAAGCGCCAATGAGTTTCAGGAATGAAGTAGAAGGTAGTTATTTAA           AAATAAAAAACACAGTCCGTCCCTACCAATAGAGGAAAATGGTTTTAATGTTTGCTGGTCAGACAGAC           AAATGGGCTAGAGTAAGAGGGCTGCGGGTATGAGAGACCCCGGCTCCGCCCTGGCACGTGTCCTTGCT           GGCGGCCCGCCACAGGCCCCCTTCAATGGCCGCATTCAGGATGGCTCTATACACAGCAGTGCTGGTTT           ATGTAAAGTTCAGCAGTCACTTCA                                           NOV6m, SNP13376335 of   SEQ ID NO: 106   453 aa   MW at 50669.5kD           CG50391-08, Protein   SNP Pos: 91       SNP Change: Ala to Val       Sequence                     MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRG           QVQPQASNMEYMTWDDELEKSA   V   AWASQCIWEHGPTSLLVSIGQNLGAHWGRIVWVTTNKIGCAVNTC       RKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDE       MNEVETAPIPEENHVWLQPRVMRPTKPKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHK       AKIFGSLFYESSSSICRAAIHYGILDDKGGLVDITPNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKV       KVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVISNE       SGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ                                     NOV6n, SNP13376334 of   SEQ ID NO: 107   2268 bp           CG50391-08, DNA Sequence   ORF Start: ATG at 206   ORF Stop: TGA at 1565           SNP Pos: 798   SNP Change: C to T                       CTCTGACTGCTCCTATTGAGCTGTCTGCTCGCTGTGCCCGCTGTGCCTGCTGTGCCCGCGCTGTCGCC               GCTGCTACCGCGTCTACTGGACGCGGGAGACGCCAGCGAGCTGGTGATTGGAGCCCTGCGGAGAGCTC           AAGCGCCCAGCTCTGCCCGAGGAGCCCAGGCTGCCCCGTGAGTCCCATAGTTGCTGCAGGAGTGGAGC           C   ATG AGCTGCGTCCTGGGTGGTGTCATCCCCTTGGGGCTGCTGTTCCTGGTCTGCGGATCCCAAGGCT       ACCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCAGCAAATACCAGCACAACGAGTCTCACTCC       CGGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAGATCCTCATGCTGCACAACAAGCTTCGGGG       CCAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGACCTGGGATGACGAACTGGAGAAGTCTGCTG       CAGCGTGGGCCAGTCAGTGCATCTGGGAGCACGGGCCCACCAGTCTGCTGGTGTCCATCGGGCAGAAC       CTGGGCGCTCACTGGGGCAGAATAGTTTGGGTCACCACCAACAAGATCGGTTGTGCTGTGAACACCTG       CCGGAAGATGACTGTCTGGGGAGAAGTTTGGGAGAACGCGGTCTACTTTGTCTGCAATTATTCTCCAA       AGGGGAACTGGATTGGAGAAGCCCCCTACAAGAATGGCCGGCCCTGCTCTGAGTGCCCACCCAGCTAT       GGAGGCAGCTGCAGGAACAACTTGTGTTACCGAGAAGAAACCTACACTCTAAAACCTGAAACGGACGA       GATGAATGAGGTGGAAACGGCTCCCATTCCTGAAGAAAACCATGTTTGGCTCCAACCGAGGGTGATGA       GACCCACCAAGCCCAAGAAAACCTCTGCGGTCAACTACATGACCCAAGTCGTCAGATGTGACACCAAG       ATGAAGGACAGGTGCAAAGGGTCCACGTGTAACAGGTACCAGTGCCCAGCAGGCTGCCTGAACCACAA       GGCGAAGATCTTTGGAAGTCTGTTCTATGAAAGCTCGTCTAGCATATGCCGCGCCGCCATCCACTACG       GGATCCTGGATGACAAGGGAGGCCTGGTGGATATCACCAGGAACGGGAAGGTCCCCTTCTTCGTGAAG       TCTGAGAGACACGGCGTGCAGTCCCTCAGCAAATACAAACCTTCCAGCTCATTCATGGTGTCAAAAGT       GAAAGTGCAGGATTTGGACTGCTACACGACCGTTGCTCAGCTGTGCCCGTTTGAAAAGCCAGCAACTC       ACTGCCCAAGAATCCATTGTCCGGCACACTGCAAAGACGAACCTTCCTACTGGGCTCCGGTGTTTGGA       ACCAACATCTATGCAGATACCTCAAGCATCTGCAAGACAGCCGTGCACGCGGGAGTCATCAGCAACGA       GAGTGGGGGTGACGTGGACGTGATGCCCGTGGATAAAAAGAAGACCTACGTGGGCTCGCTCAGGAATG       GAGTTCAGTCTGAAAGCCTGGGGACTCCTCGGGATGGAAAGGCCTTCCGGATCTTTGCTGTCAGGCAG         TGA   ATTTCCAGCACCAGGGGAGAAGGGGCGTCTTCAGGAGGGCTTCGGGGTTTTGCTTTTATTTTTAT           TTTGTCATTGCGGGGTATATGGAGAGTCAGGAAACTTCCTTTGACTGATGTTCAGTGTCCATCACTTT           GTGGCCTGTGGGTGAGGTGACATCTCATCCCCTCACTGAAGCAACAGCATCCCAAGGTGCTCAGCCGG           ACTCCCTGGTGCCTGATCCTGCTGGGGCCCGGGGGTCTCCATCTGGACGTCCTCTCTCCTTTAGAGAT           CTGAGCTGTCTCTTAAAGGGGACAGTTGCCCAAAATGTTCCTTGCTATGTGTTCTTCTGTTGGTGGAG           GAAGTTGATTTCAACCTCCCTGCCAAAAGAACAAACCATTTGAAGCTCACAATTGTGAAGCATTCACG           GCGTCGGAAGAGGCCTTTTGAGCAAGCGCCAATGAGTTTCAGGAATGAAGTAGAAGGTAGTTATTTAA           AAATAAAAAACACAGTCCGTCCCTACCAATAGAGGAAAATGGTTTTAATGTTTGCTGGTCAGACAGAC           AAATGGGCTAGAGTAAGAGGGCTGCGGGTATGAGAGACCCCGGCTCCGCCCTGGCACGTGTCCTTGCT           GGCGGCCCGCCACAGGCCCCCTTCAATGGCCGCATTCAGGATGGCTCTATACACAGCAGTGCTGGTTT           ATGTAAAGTTCAGCAGTCACTTCA                                           NOV6n, SNP13376334 of   SEQ ID NO: 108   453 aa   MW at 50657.5kD           CG50391-08, Protein   SNP Pos: 198   SNP Change: Pro to Leu       Sequence                     MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRG           QVQPQASNMEYMTWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLGAHWGRIVWVTTNKIGCAVNTC       RKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYT   L   KPETDE       MNEVETAPIPEENHVWLQPRVMRPTKPKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHK       AKIFGSLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKV       KVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVISNE       SGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ                                     NOV6o, SNP13376333 of   SEQ ID NO: 109   2268 bp           CG50391-08, DNA Sequence   ORF Start: ATG at 206   ORF Stop: TGA at 1565           SNP Pos: 816   SNP Change: A to G                       CTCTGACTGCTCCTATTGAGCTGTCTGCTCGCTGTGCCCGCTGTGCCTGCTGTGCCCGCGCTGTCGCC               GCTGCTACCGCGTCTACTGGACGCGGGAGACGCCAGCGAGCTGGTGATTGGAGCCCTGCGGAGAGCTC           AAGCGCCCAGCTCTGCCCGAGGAGCCCAGGCTGCCCCGTGAGTCCCATAGTTGCTGCAGGAGTGGAGC           C   ATG AGCTGCGTCCTGGGTGGTGTCATCCCCTTGGGGCTGCTGTTCCTGGTCTGCGGATCCCAAGGCT       ACCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCAGCAAATACCAGCACAACGAGTCTCACTCC       CGGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAGATCCTCATGCTGCACAACAAGCTTCGGGG       CCAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGACCTGGGATGACGAACTGGAGAAGTCTGCTG       CAGCGTGGGCCAGTCAGTGCATCTGGGAGCACGGGCCCACCAGTCTGCTGGTGTCCATCGGGCAGAAC       CTGGGCGCTCACTGGGGCAGAATAGTTTGGGTCACCACCAACAAGATCGGTTGTGCTGTGAACACCTG       CCGGAAGATGACTGTCTGGGGAGAAGTTTGGGAGAACGCGGTCTACTTTGTCTGCAATTATTCTCCAA       AGGGGAACTGGATTGGAGAAGCCCCCTACAAGAATGGCCGGCCCTGCTCTGAGTGCCCACCCAGCTAT       GGAGGCAGCTGCAGGAACAACTTGTGTTACCGAGAAGAAACCTACACTCCAAAACCTGAAACGGACG   G           GATGAATGAGGTGGAAACGGCTCCCATTCCTGAAGAAAACCATGTTTGGCTCCAACCGAGGGTGATGA       GACCCACCAAGCCCAAGAAAACCTCTGCGGTCAACTACATGACCCAAGTCGTCAGATGTGACACCAAG       ATGAAGGACAGGTGCAAAGGGTCCACGTGTAACAGGTACCAGTGCCCAGCAGGCTGCCTGAACCACAA       GGCGAAGATCTTTGGAAGTCTGTTCTATGAAAGCTCGTCTAGCATATGCCGCGCCGCCATCCACTACG       GGATCCTGGATGACAAGGGAGGCCTGGTGGATATCACCAGGAACGGGAAGGTCCCCTTCTTCGTGAAG       TCTGAGAGACACGGCGTGCAGTCCCTCAGCA~ATACAAACCTTCCAGCTCATTCATGGTGTCAAAAGT       GAAAGTGCAGGATTTGGACTGCTACACGACCGTTGCTCAGCTGTGCCCGTTTGAAAAGCCAGCAACTC       ACTGCCCAAGAATCCATTGTCCGGCACACTGCAAAGACGAACCTTCCTACTGGGCTCCGGTGTTTGGA       ACCAACATCTATGCAGATACCTCAAGCATCTGCAAGACAGCCGTGCACGCGGGAGTCATCAGCAACGA       GAGTGGGGGTGACGTGGACGTGATGCCCGTGGATAAAAAGAAGACCTACGTGGGCTCGCTCAGGAATG       GAGTTCAGTCTGAAAGCCTGGGGACTCCTCGGGATGGAAAGGCCTTCCGGATCTTTGCTGTCAGGCAG         TGA   ATTTCCAGCACCAGGGGAGAAGGGGCGTCTTCAGGAGGGCTTCGGGGTTTTGCTTTTATTTTTAT           TTTGTCATTGCGGGGTATATGGAGAGTCAGGAAACTTCCTTTGACTGATGTTCAGTGTCCATCACTTT           GTGGCCTGTGGGTGAGGTGACATCTCATCCCCTCACTGAAGCAACAGCATCCCAAGGTGCTCAGCCGG           ACTCCCTGGTGCCTGATCCTGCTGGGGCCCGGGGGTCTCCATCTGGACGTCCTCTCTCCTTTAGAGAT           CTGAGCTGTCTCTTAAAGGGGACAGTTGCCCAAAATGTTCCTTGCTATGTGTTCTTCTGTTGGTGGAG           GAAGTTGATTTCAACCTCCCTGCCAAAAGAACAAACCATTTGAAGCTCACAATTGTGAAGCATTCACG           GCGTCGGAAGAGGCCTTTTGAGCAAGCGCCAATGAGTTTCAGGAATGAAGTAGAAGGTAGTTATTTAA           AAATAAAAAACACAGTCCGTCCCTACCAATAGAGGAAAATGGTTTTAATGTTTGCTGGTCAGACAGAC           AAATGGGCTAGAGTAAGAGGGCTGCGGGTATGAGAGACCCCGGCTCCGCCCTGGCACGTGTCCTTGCT           GGCGGCCCGCCACAGGCCCCCTTCAATGGCCGCATTCAGGATGGCTCTATACACAGCAGTGCTGGTTT           ATGTAAAGTTCAGCAGTCACTTCA                                           NOV6o, SNP13376333 of   SEQ ID NO: 110   453 aa   MW at 50569.4kD           CG50391-08, Protein   SNP Pos: 204       SNP Change: Glu to Gly       Sequence                     MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRPAIPREDKEEILMLHNKLRG           QVQPQASNNEYMTWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLGAHWGRIVWVTTNKIGCAVNTC       RKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETD   G           MNEVETAPIPEENHVWLQPRVMRPTKPKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHK       AKIFGSLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKV       KVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKTAVHAGVISNE       SGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ                                     NOV6p, SNP13382488 of   SEQ ID NO: 111   2268 bp           CG50391-08, DNA Sequence   ORF Start: ATG at 206   ORF Stop: TGA at 1565           SNP Pos: 1402   SNP Change: C to T                       CTCTGACTGCTCCTATTGAGCTGTCTGCTCGCTGTGCCCGCTGTGCCTGCTGTGCCCGCGCTGTCGCC               GCTGCTACCGCGTCTACTGGACGCGGGAGACGCCAGCGAGCTGGTGATTGGAGCCCTGCGGAGAGCTC           AAGCGCCCAGCTCTGCCCGAGGAGCCCAGGCTGCCCCGTGAGTCCCATAGTTGCTGCAGGAGTGGAGC           C   ATG AGCTGCGTCCTGGGTGGTGTCATCCCCTTGGGGCTGCTGTTCCTGGTCTGCGGATCCCAAGGCT       ACCTCCTGCCCAACGTCACTCTCTTAGAGGAGCTGCTCAGCAAATACCAGCACAACGAGTCTCACTCC       CGGGTCCGCAGAGCCATCCCCAGGGAGGACAAGGAGGAGATCCTCATGCTGCACAACAAGCTTCGGGG       CCAGGTGCAGCCTCAGGCCTCCAACATGGAGTACATGACCTGGGATGACGAACTGGAGAAGTCTGCTG       CAGCGTGGGCCAGTCAGTGCATCTGGGAGCACGGGCCCACCAGTCTGCTGGTGTCCATCGGGCAGAAC       CTGGGCGCTCACTGGGGCAGAATAGTTTGGGTCACCACCAACAAGATCGGTTGTGCTGTGAACACCTG       CCGGAAGATGACTGTCTGGGGAGAAGTTTGGGAGAACGCGGTCTACTTTGTCTGCAATTATTCTCCAA       AGGGGAACTGGATTGGAGAAGCCCCCTACAAGAATGGCCGGCCCTGCTCTGAGTGCCCACCCAGCTAT       GGAGGCAGCTGCAGGAACAACTTGTGTTACCGAGAAGAAACCTACACTCCAAAACCTGAAACGGACGA       GATGAATGAGGTGGAAACGGCTCCCATTCCTGAAGAAAACCATGTTTGGCTCCAACCGAGGGTGATGA       GACCCACCAAGCCCAAGAAAACCTCTGCGGTCAACTACATGACCCAAGTCGTCAGATGTGACACCAAG       ATGAAGGACAGGTGCAAAGGGTCCACGTGTAACAGGTACCAGTGCCCAGCAGGCTGCCTGAACCACAA       GGCGAAGATCTTTGGAAGTCTGTTCTATGAAAGCTCGTCTAGCATATGCCGCGCCGCCATCCACTACG       GGATCCTGGATGACAAGGGAGGCCTGGTGGATATCACCAGGAACGGGAAGGTCCCCTTCTTCGTGAAG       TCTGAGAGACACGGCGTGCAGTCCCTCAGCAAATACAAACCTTCCAGCTCATTCATGGTGTCAAAAGT       GAAAGTGCAGGATTTGGACTGCTACACGACCGTTGCTCAGCTGTGCCCGTTTGAAAAGCCAGCAACTC       ACTGCCCAAGAATCCATTGTCCGGCACACTGCAAAGACGAACCTTCCTACTGGGCTCCGGTGTTTGGA       ACCAACATCTATGCAGATACCTCAAGCATCTGCAAGACAGC   T   GTGCACGCGGGAGTCATCAGCAACGA       GAGTGGGGGTGACGTGGACGTGATGCCCGTGGATAAAAAGAAGACCTACGTGGGCTCGCTCAGGAATG       GAGTTCAGTCTGAAAGCCTGGGGACTCCTCGGGATGGAAAGGCCTTCCGGATCTTTGCTGTCAGGCAG         TGA   ATTTCCAGCACCAGGGGAGAAGGGGCGTCTTCAGGAGGGCTTCGGGGTTTTGCTTTTATTTTTAT           TTTGTCATTGCGGGGTATATGGAGAGTCAGGAAACTTCCTTTGACTGATGTTCAGTGTCCATCACTTT           GTGGCCTGTGGGTGAGGTGACATCTCATCCCCTCACTGAAGCAACAGCATCCCAAGGTGCTCAGCCGC           ACTCCCTGGTGCCTGATCCTGCTGGGGCCCGGGGGTCTCCATCTGGACGTCCTCTCTCCTTTAGAGAT           CTGAGCTGTCTCTTAAAGGGGACAGTTGCCCAAAATGTTCCTTGCTATGTGTTCTTCTGTTGGTGGAG           GAAGTTGATTTCAACCTCCCTGCCAAAAGAACAAACCATTTGAAGCTCACAATTGTGAAGCATTCACG           GCGTCGGAAGAGGCCTTTTGAGCAAGCGCCAATGAGTTTCAGGAATGAAGTAGAAGGTAGTTATTTAA           AAATAAAAAACACAGTCCGTCCCTACCAATAGAGGAAAATGGTTTTAATGTTTGCTGGTCAGACAGAC           AAATGGGCTAGAGTAAGAGGGCTGCGGGTATGAGAGACCCCGGCTCCGCCCTGGCACGTGTCCTTGCT           GGCGGCCCGCCACAGGCCCCCTTCAATGGCCGCATTCAGGATGGCTCTATACACAGCAGTGCTGGTTT           ATGTAAAGTTCAGCAGTCACTTCA                                           NOV6p, SNP13382488 of   SEQ ID NO: 112   453 aa   MW at 50641.5kD           CG50391-08, Protein   SNP Pos: 399       SNP Change: Ala to Ala       Sequence                     MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRPAIPREDKEEILMLHNKLRG           QVQPQASNMEYMTWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLGAHWGRIVWVTTNKIGCAVNTC       RKMTVWGEVWENAVYFVCNYSPKGNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDE       MNEVETAPIPEENHVWLQPRVMRPTKPKKTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHK       AKIFGSLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSSSFMVSKV       KVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTSSICKT   A   VHAGVISNE       SGGDVDVMPVDKKKTYVGSLENGVQSESLGTPPDGKAFRIFAVRQ                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 6B.  
               TABLE 6B                       Comparison of the NOV6 protein sequences.                                        NOV6a ----------------------------------------MSCVLGGVIPLGLLFLVCGS           NOV6b ----------------------------------------MSCVLGGVIPLGLLFLVCGS       NOV6c ----------------------------------------MSCVLGGVIPLGLLFLVCGS       NOV6d ------------------------------------------------------------       NOV6e ----------------------------------------MSCVLGGVIPLGLLFLVCGS       NOV6f ----------------------------------------MSCVLGGVIPLGLLFLVRGS       NOVGg ----------------------------------------MSCVLGGVIPLGLLFLVRGS       NOV6h ----------------------------------------MSCVLGGVIPLGLLFLVRGS       NOV6i ----------------------YLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEIL       NOVGj ----------------------------------------MSCVLGGVIPLGLLFLVCGS       NOVGk MSCVLGGVIPLGLLFLVCGSQGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEIL               NOV6a QGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRGQVQPQAS-----       NOV6b QGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRGQVQPQAS-----       NOV6c QGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRGQVQPQAS-----       NOV6d ------------------------------------------------------M-----       NOV6e QGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRGQVQPQASNMEYM       NOV6f QGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRGQVQPQASNMEYM       NOV6g QGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRGQVQPQAS-----       NOV6h QGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRGQVQPQASNMEYM       NOV6i MLHNKLRGQVQPQASNMEYMTWDDELEKSAAAWASQCIWEHGPTGLLVSIGQNLG-----       NOV6j QGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKLRGQVQPQASNMEYM       NOV6k MLHNKLRGQVQPQASNMEYMTWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLG-----               NOV6a ------------------------------------------N--MEYMTWDDELEKSAA       NOV6b -----------------------------------NMEYMYRSPGFHVQSWYDEVKDYTY       NOV6c ------------------------------------------N--MEYMTWDDELEKSAA       NOV6d -----------------------------------TNWGRYRSPGFHVQSWYDEVKDYTY       NOV6e TWDDELEKSAAAWASQCIWEHGPTGLLVSIGQNLGAHWGRYRSPGFHVQSWYDEVKDYTY       NOV6f TWDDELEKSAAAWASQCIWEHGPTGLLVSIGQNLGAHWGRYRSPGFHVQSWYDEVKDYTY       NOV6g ------------------------------------------N--MEYMTWDDELEKSAA       NOVGh TWDDELEKSAAAWASQCIWEHGPTGLLVSIGQNLGAHWGRYRSPGFHVQSWYDEVKDYTY       NOV6i -----------------------------------AHWGRYRSPGFHVQSWYDEVKDYTY       NOV6j TWDDELEKSAAAWASQCIWEHGPTSLLVSIGQNLGAHWGRYRSPGFHVQSWYDEVKDYTY       NOV6k -----------------------------------AHWGRYRSPGFHVQSWYDEVKDYTY               NOV6a AWASQC-----------IWEHG--PTSLLVSIGQNLGAHWGRIV----------------       NOV6b PYPSECNPWCPERCSGPMCTHY---TQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFV       NOV6c AWASQC-----------IWEHG--PTSLLVSIGQNLGAHWG-------------------       NOV6d PYPSECNPWCPERCSGPMCTHY---TQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFV       NOV6e PYPSECNPWCPERCSGPMCTHY---TQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFV       NOV6f PYPSECNPWCPERCSGPMCTHY---TQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFV       NOV6g AWASQC-----------IWEHG--PTSLLVSIGQNLGAHWGRRYRSPGFHVQSWYDEVKD       NOV6h PYPSECNPWCPERCSGPMCTHYTQVTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFV       NOV6i PYPSECNPWCPERCSGPMCTHY---TQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFV       NOV6j PYPSECNPWCPERCSGPMCTHY---TQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFV       NOV6k PYPSECNPWCPERCSGPMCTHY---TQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFV               NOV6a -----------------------------WVTTNKIGCAVNTCRKMTVWGEVWENAVYFV       NOV6b CNYSPK------------------------------------------------------       NOV6c ------------------------------------------------------------       NOV6d CNYSPK------------------------------------------------------       NOV6e CNYSPK------------------------------------------------------       NOV6f CNYSPK------------------------------------------------------       NOV6g YTYPYPSECNPWCPERCSGPMCTHYTQIVWATTNKIGCAVNTCRKMTVWGEVWENAVYFV       NOVGh CNYSPKR-----------------------------------------------------       NOV6i CNYSPK------------------------------------------------------       NOV6j CNYSPK------------------------------------------------------       NOV6k CNYSPK------------------------------------------------------               NOV6a CNYSPKGNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPI       NOV6b ------GNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPI       NOV6c -----RGNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPI       NOV6d ------GNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPI       NOV6e ------GNWIGEAPYKNGRPCSQCPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPI       NOV6f ------GNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPI       NOV6g CNYSPKGNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPI       NOV6h ------GNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPI       NOV6i ------GNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPI       NOV6j ------GNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPI       NOV6k ------GNWIGEAPYKNGRPCSECPPSYGGSCRNNLCYREETYTPKPETDEMNEVGTAPI               NOV6a PEENHVWLQPRVMRPTKPKXTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKA       NOV6b PEENHVWLQPRVMRPTKPKXTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKA       NOV6c PEENHVWLQPRVMRPTKPKXTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKA       NOV6d PEENHVWLQPRVMRPTKPKXTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKA       NOV6e PEENHVWLQPRVMRPTKPKXTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKA       NOV6f PEENHVWLQPRVMRPTKPKXTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKA       NOV6g PEENHVWLQPRVMRPTKPKXTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKA       NOV6h PEENHVWLQPRVMRPTKPKXTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKA       NOV6i PEENHVWLQPRVMRPTKPKXTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKA       NOV6j PEENHVWLQPRVMRPTKPKXTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKA       NOV6k PEENHVWLQPRVMRPTKPKXTSAVNYMTQVVRCDTKMKDRCKGSTCNRYQCPAGCLNHKA               NOV6a KIFGSLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSS       NOV6b KIFGTLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSS       NOV6c KIFGSLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSL-------       NOV6d KIFGTLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSS       NOV6e KIFGTLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSS       NOV6f KIFGTLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSS       NOV6g KIFGSLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSS       NOV6h KIFGSLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSS       NOV6i KIFGTLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSS       NOV6j KIFGSLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSS       NOV6k KIFGTLFYESSSSICRAAIHYGILDDKGGLVDITRNGKVPFFVKSERHGVQSLSKYKPSS               NOV6a SFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTS       NOV6b SFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTS       NOV6c --------VQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTS       NOV6d SFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTS       NOV6e SFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTS       NOV6f SFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTS       NOV6g SFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTS       NOV6h SFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTS       NOV6i SFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTS       NOV6j SFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTS       NOV6k SFMVSKVKVQDLDCYTTVAQLCPFEKPATHCPRIHCPAHCKDEPSYWAPVFGTNIYADTS               NOV6a SICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ       NOV6b SICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ       NOV6c SICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ       NOV6d SICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ       NOV6e SICKTAVHAGVISNESGGDVDVMPVDKKKTYTCPAAARAL--------------------       NOV6f SICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ       NOV6g SICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ       NOV6h SICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ       NOV6i SICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ       NOV6j SICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ       NOV6k SICKTAVHAGVISNESGGDVDVMPVDKKKTYVGSLRNGVQSESLGTPRDGKAFRIFAVRQ               NOV6a (SEQ ID NO: 82)       NOV6b (SEQ ID NO: 84)       NOV6c (SEQ ID NO: 86)       NOV6d (SEQ ID NO: 88)       NOV6e (SEQ ID NO: 90)       NOV6f (SEQ ID NO: 92)       NOV6g (SEQ ID NO: 94)       NOV6h (SEQ ID NO: 96)       NOV6i (SEQ ID NO: 98)       NOV6j (SEQ ID NO: 100)       NOV6k (SEQ ID NO: 102)                  
 
      Further analysis of the NOV6a protein yielded the following properties shown in Table 6C.  
               TABLE 6C                       Protein Sequence Properties NOV6a                                        SignalP analysis:   Cleavage site between residues 23 and 24       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 0; pos. chg 0; neg. chg 0           H-region:   length 31; peak value 10.73           PSG score:   6.33                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −0.72           possible cleavage site: between 22 and 23                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 22)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 23           Tentative number of TMS(s) for the threshold 0.5: 0           number of TMS(s) . . . fixed                             PERIPHERAL   Likelihood = 7.37 (at 106)                         ALOM score: 7.37 (number of TMSs: 0)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 11           Charge difference: −1.0 C(0.0)-N(1.0)           N &gt;= C: N-terminal side will be inside       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment (75):   0.40           Hyd Moment (95):   3.00   G content:   5           D/E content:   1   S/T content:   3                         Score: −7.63       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: KPKK (4) at 230           pat7: PTKPKKT (4) at 228           pat7: PVDKKKT (4) at 417           bipartite: none           content of basic residues: 11.9%           NLS Score: 0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear           discrimination           Prediction: nuclear           Reliability: 55.5       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         52.2%: nuclear           21.7%: extracellular, including cell wall           17.4%: mitochondrial            4.3%: vacuolar            4.3%: cytoplasmic                 &gt;&gt; prediction for CG50391-08 is nuc (k = 23)                  
 
      A search of the NOV6a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 6D.  
               TABLE 6D                          Geneseq Results for NOV6a                                         NOV6a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length [Patent #,   Match   the Matched   Expect       Identifier   Date]   Residues   Region   Value               AAU83619   Human PRO protein, Seq ID No 56 -   1 . . . 453   452/497 (90%)   0.0             Homo sapiens , 497 aa.   1 . . . 497   452/497 (90%)           [WO200208288-A2, 31-JAN-2002]       AAO21721   Human secreted protein SEQ ID No 63 -   1 . . . 453   452/497 (90%)   0.0             Homo sapiens , 497 aa.   1 . . . 497   452/497 (90%)           [WO200238602-A2, 16-MAY-2002]       AAB74446   Human protease-inhibitor like protein -   1 . . . 453   452/497 (90%)   0.0             Homo sapiens , 497 aa.   1 . . . 497   452/497 (90%)           [WO200121651-A2, 29-MAR-2001]       AAE10618   Human novel trypsin inhibitor-like   1 . . . 453   451/498 (90%)   0.0           protein, NOV-4d -  Homo sapiens , 498   1 . . . 498   451/498 (90%)           aa. [WO200162928-A2, 30-AUG-2001]       AAE10616   Human novel trypsin inhibitor-like   1 . . . 453   450/497 (90%)   0.0           protein, NOV-4b -  Homo sapiens , 497   1 . . . 497   450/497 (90%)           aa. [WO200162928-A2, 30-AUG-2001]                  
 
      In a BLAST search of public sequence databases, the NOV6a protein was found to have homology to the proteins shown in the BLASTP data in Table 6E.  
               TABLE 6E                          Public BLASTP Results for NOV6a                                         NOV6a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q9H0B8   Hypothetical protein -  Homo     1 . . . 453   451/497 (90%)   0.0             sapiens  (Human), 497 aa.   1 . . . 497   452/497 (90%)       CAC69820   Sequence 20 from Patent   1 . . . 453   451/498 (90%)   0.0           WO0162928 -  Homo sapiens     1 . . . 498   451/498 (90%)           (Human), 498 aa.       CAC69818   Sequence 16 from Patent   1 . . . 453   450/497 (90%)   0.0           WO0162928 -  Homo sapiens     1 . . . 497   450/497 (90%)           (Human), 497 aa.       CAC69821   Sequence 22 from Patent   1 . . . 453   450/501 (89%)   0.0           WO0162928 -  Homo sapiens     1 . . . 501   450/501 (89%)           (Human), 501 aa.       CAC69817   Sequence 14 from Patent   81 . . . 453    339/373 (90%)   0.0           WO0162928 -  Homo sapiens     16 . . . 383    348/373 (92%)           (Human), 383 aa.                  
 
      PFam analysis predicts that the NOV6a protein contains the domains shown in the Table 6F.  
               TABLE 6F                          Domain Analysis of NOV6a                                             Identities/                       Similarities           Pfam   NOV6a Match   for the   Expect           Domain   Region   Matched Region   Value                       SCP    60 . . . 155   45/167 (27%)   7.4e−23                   76/167 (46%)           LCCL   244 . . . 335   47/104 (45%)   6.1e−49                   84/104 (81%)           LCCL   345 . . . 444   55/104 (53%)   1.6e−51                   89/104 (86%)                      
 
     Example 7  
      The NOV7 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 7A.  
               TABLE 7A                       NOV7 Sequence Analysis                                                        NOV7a, CG50426-17   SEQ ID NO: 113   8160 bp               DNA Sequence   ORF Start: ATG at 122   ORF Stop: TAA at 8108                       GGGAGTTGGAACCAGCATTAGATGAGTTGACAAAAATGCAGTTTCAGGTGGCAAAGTGACAAGTGCCA               AAACTCAGGCCTGACTTTTCTGAAAACATCAGCATTCTGCCATATCTGGAATA   ATG GATGTAAAGGAC       CGGCGACACCGCTCTTTGACCAGAGGACGCTGTGGCAAAGAGTGTCGCTACACAAGCTCCTCTCTGGA       CAGTGAGGACTGCCGGGTGCCCACACAGAAATCCTACAGCTCCAGTGAGACTCTGAAGGCCTATGACC       ATGACAGCAGGATGCACTATGGAAACCGAGTCACAGACCTCATCCACCGGGAGTCAGATGAGTTTCCT       AGACAAGGAACCAACTTCACCCTTGCCGAACTGGGCATCTGTGAGCCCTCCCCACACCGAAGCGGCTA       CTGCTCCGACATGGGGATCCTTCACCAGGGCTACTCCCTTAGCACAGGGTCTGACGCCGACTCCGACA       CCGAGGGAGGGATGTCTCCAGAACACGCCATCAGACTGTGGGGCAGAGGGATAAAATCCAGGCGCAGT       TCCGGCCTGTCCAGTCGTGAAAACTCGGCCCTTACCCTGACTGACTCTGACAACGAAAACAAATCAGA       TGATGAGAACGGTCGTCCCATTCCACCTACATCCTCGCCTAGTCTCCTCCCATCTGCTCAGCTGCCTA       GCTCCCATAATCCTCCACCAGTTAGCTGCCAGATGCCATTGCTAGACAGCAACACCTCCCATCAAATC       ATGGACACCAACCCTGATGAGGAATTCTCCCCCAATTCATACCTGCTCAGAGCATGCTCAGGGCCCCA       GCAAGCCTCCAGCAGTGGCCCTCCGAACCACCACAGCCAGTCGACTCTGAGGCCCCCTCTCCCACCCC       CTCACAACCACACGCTGTCCCATCACCACTCGTCCGCCAACTCCCTCAACAGGAACTCACTGACCAAT       CGGCGGAGTCAGATCCACGCCCCGGCCCCAGCGCCCAATGACCTGGCCACCACACCAGAGTCCGTTCA       GCTTCAGGACAGCTGGGTGCTAAACAGCAACGTGCCACTGGAGACCCGGCACTTCCTCTTCAAGACCT       CCTCGGGGAGCACACCCTTGTTCAGCAGCTCTTCCCCGGGATACCCTTTGACCTCAGGAACGGTTTAC       ACGCCCCCGCCCCGCCTGCTGCCCAGGAATACTTTCTCCAGGAAGGCTTTCAAGCTGAAGAAGCCCTC       CAAATACTGCAGCTGGAAATGTGCTGCCCTCTCCGCCATTGCCGCGGCCCTCCTCTTGGCTATTTTGC       TGGCGTATTTCATAGTGCCCTGGTCGTTGAAAAACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGT       CGGCGGGTAACACAAGAAGTCCCACCAGGGGTGTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCA       GTTCTTAAAGTTCAACATCTCCCTCGGGAAGGACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTC       CACCATCTCATGCCCAGTATGACTTCATGGAACGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAG       TCTCCCAGGGAACGCCGGAGCATACAGACCTTGGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGA       TGTGGGCCTGTGGCATCTGGCCTTCTACAATGATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTG       TTGTCCTAGATTCAGTGCAGGACTGTCCACGTAACTGCCATGGGAATGGTGAATGTGTGTCCGGGGTG       TGTCACTGTTTCCCAGGATTTCTAGGAGCAGACTGTGCTAAAGCTGCCTGCCCTGTCCTGTGCAGTGG       GAATGGACAATATTCTAAAGGGACGTGCCAGTGCTACAGCGGCTGGAAAGGTGCAGAGTGCGACGTGC       CCATGAATCAGTGCATCGATCCTTCCTGCGGGGGCCACGGCTCCTGCATTGATGGGAACTGTGTCTGC       TCTGCTGGCTACAAAGGCGAGCACTGTGAGGAAGTTGATTGCTTGGATCCCACCTGCTCCAGCCACGG       AGTCTGTGTGAATGGAGAATGCCTGTGCAGCCCTGGCTGGGGTGGTCTGAACTGTGAGCTGGCGAGGG       TCCAGTGCCCAGACCAGTGCAGTGGGCATGGCACGTACCTGCCTGACACGGGCCTCTGCAGCTGCGAT       CCCAACTGGATGGGTCCCGACTGCTCTGTTGATGGCTGCCCTGACTTGTGCAACGGTAACGGGAGATG       CACACTGGGTCAGAACAGCTGGCAGTGTGTCTGCCAGACCGGCTGGAGAGGGCCCGGATGCAACGTTG       CCATGGAAACTTCCTGTGCTGATAACAAGGATAATGAGGGAGATGGCCTGGTGGATTGTTTGGACCCT       GACTGCTGCCTGCAGTCAGCCTGTCAGAACAGCCTGCTCTGCCGGGGGTCCCGGGACCCACTGGACAT       CATTCAGCAGGGCCAGACGGATTGGCCCGCAGTGAAGTCCTTCTATGACCGTATCAAGCTCTTGGCAG       GCAAGGATAGCACCCACATCATTCCTGGAGAGAACCCTTTCAACAGCAGCTTGGTTTCTCTCATCCGA       GGCCAAGTAGTAACTACAGATGGAACTCCCCTGGTCGGTGTGAACGTGTCTTTTGTCAAGTACCCAAA       ATACGGCTACACCATCACCCGCCAGGATGGCACGTTCGACCTGATCGCAAATGGAGGTGCTTCCTTGA       CTCTACACTTTGAGCGAGCCCCGTTCATGAGCCAGGAGCGCACTGTGTGGCTGCCGTGGAACAGCTTT       TACGCCATGGACACCCTGGTGATGAAGACCGAGGAGAACTCCATCCCCAGCTGTGACCTCAGTGGCTT       TGTCCGGCCTGATCCAATCATCATCTCCTCCCCACTGTCCACCTTCTTTAGTGCTGCCCCTGGGCAGA       ATCCCATCGTGCCTGAGACCCAGGTTCTTCATGAAGAAATCGAGCTCCCTGGTTCCAATGTGAAACTT       CGCTATCTGAGCTCTAGAACTGCAGGGTACAAGTCACTGCTGAAGATCACCATGACCCAGTCCACAGT       GCCCCTGAACCTCATTAGGGTTCACCTGATGGTGGCTGTCGAGGGGCATCTCTTCCAGAAGTCATTCC       AGGCTTCTCCCAACCTGGCCTCCACCTTCATCTGGGACAAGACAGATGCGTATGGCCAAAGGGTGTAT       GGACTCTCAGATGCTGTTGTGTCTGTCGGGTTTGAATATGAGACCTGTCCCAGTCTAATTCTCTGGGA       GAAAAGGACAGCCCTCCTTCAGGGATTCGAGCTGGACCCCTCCAACCTCGGTGGCTGGTCCCTAGACA       AACACCACATCCTCAATGTTAAAAGTGGAATCCTACACAAAGGCACTGGGGAAAACCAGTTCCTGACC       CAGCAGCCTGCCATCATCACCAGCATCATGGGCAATGGTCGCCGCCGGAGCATTTCCTGTCCCAGCTG       CAACGGCCTTGCTGAAGGCAACAAGCTGCTGGCCCCAGTGGCTCTGGCTGTTGGAATCGATGGGAGCC       TCTATGTGGGTGACTTCAATTACATCCGACGCATCTTTCCCTCTCGAAATGTGACCAGCATCTTGGAG       TTACGAAATAAAGAGTTTAAACATAGCAACAACCCAGCACACAAGTACTACTTGGCAGTGGACCCCGT       GTCCGGCTCGCTCTACGTGTCCGACACCAACAGCAGGAGAATCTACCGCGTCAAGTCTCTGAGTGGAA       CCAAAGACCTGGCTGGGAATTCGGAAGTTGTGGCAGGGACGGGAGAGCAGTGTCTACCCTTTGATGAA       GCCCGCTGCGGGGATGGAGGGAAGGCCATAGATGCAACCCTGATGAGCCCGAGAGGTATTGCAGTAGA       CAAGAATGGGCTCATGTACTTTGTCGATGCCACCATGATCCGGAAGGTTGACCAGAATGGAATCATCT       CCACCCTGCTGGGCTCCAATGACCTCACTGCCGTCCGGCCGCTGAGCTGTGATTCCAGCATGGATGTA       GCCCAGGTTCGTCTGGAGTGGCCAACAGACCTTGCTGTCAATCCCATGGATAACTCCTTGTATGTTCT       AGAGAACAATGTCATCCTTCGAATCACCGAGAACCACCAAGTCAGCATCATTGCGGGACGCCCCATGC       ACTGCCAAGTTCCTGGCATTGACTACTCACTCAGCAAACTAGCCATTCACTCTGCCCTGGAGTCAGCC       AGTGCCATTGCCATTTCTCACACTGGGGTCCTCTACATCACTGAGACAGATGAGAAGAAGATTAACCG       TCTACGCCAGGTAACAACCAACGGGGAGATCTGCCTTTTAGCTGGGGCAGCCTCGGACTGCGACTGCA       AAAACGATGTCAATTGCAACTGCTATTCAGGAGATGATGCCTACGCGACTGATGCCATCTTGAATTCC       CCATCATCCTTAGCTGTAGCTCCAGATGGTACCATTTACATTGCAGACCTTGGAAATATTCGGATCAG       GGCGGTCAGCAAGAACAAGCCTGTTCTTAATGCCTTCAACCAGTATGAGGCTGCATCCCCCGGAGAGC       AGGAGTTATATGTTTTCAACGCTGATGGCATCCACCAATACACTGTGAGCCTGGTGACAGGGGAGTAC       TTGTACAATTTCACATATAGTACTGACAATGATGTCACTGAATTGATTGACAATAATGGGAATTCCCT       GAAGATCCGTCGGGACAGCAGTGGCATGCCCCGTCACCTGCTCATGCCTGACAACCAGATCATCACCC       TCACCGTGGGCACCAATGGAGGCCTCAAAGTCGTGTCCACACAGAACCTGGAGCTTGGTCTCATGACC       TATGATGGCAACACTGGGCTCCTGGCCACCAAGAGCGATGAAACAGGATGGACGACTTTCTATGACTA       TGACCACGAAGGCCGCCTGACCAACGTGACGCGCCCCACGGGGGTGGTAACCAGTCTGCACCGGGAAA       TGGAGAAATCTATTACCATTGACATTGAGAACTCCAACCGTGATGATGACGTCACTGTCATCACCAAC       CTCTCTTCAGTAGAGGCCTCCTACACAGTGGTACAAGATCAAGTTCGGAACAGCTACCAGCTCTGTAA       TAATGGTACCCTGAGGGTGATGTATGCTAATGGGATGGGTATCAGCTTCCACAGCGAGCCCCATGTCC       TAGCGGGCACCATCACCCCCACCATTGGACGCTGCAACATCTCCCTGCCTATGGAGAATGGCTTAAAC       TCCATTGAGTGGCGCCTAAGAAAGGAACAGATTAAAGGCAAAGTCACCATCTTTGGCAGGAAGCTCCG       GGTCCATGGAAGAAATCTCTTGTCCATTGACTATGATCGAAATATTCGGACTGAAAAGATCTATGATG       ACCACCGGAAGTTCACCCTGAGGATCATTTATGACCAGGTGGGCCGCCCCTTCCTCTGGCTGCCCAGC       AGCGGGCTGGCAGCTGTCAACGTGTCATACTTCTTCAATGGGCGCCTGGCTGGGCTTCAGCGTGGGGC       CATGAGCGAGAGGACAGACATCGACAAGCAAGGCCGCATCGTGTCCCGCATGTTCGCTGACGGGAAAG       TGTGGAGCTACTCCTACCTTGACAAGTCCATGGTCCTCCTGCTTCAGAGCCAACGTCAGTATATATTT       GAGTATGACTCCTCTGACCGCCTCCTTGCCGTCACCATGCCCAGCGTGGCCCGGCACAGCATGTCCAC       ACACACCTCCATCGGCTACATCCGTAATATTTACAACCCGCCTGAAAGCAATGCTTCGGTCATCTTTG       ACTACAGTGATGACGGCCGCATCCTGAAGACCTCCTTTTTGGGCACCGGACGCCAGGTGTTCTACAAG       TATGGGAAACTCTCCAAGTTATCAGAGATTGTCTACGACAGTACCGCCGTCACCTTCGGGTATGACGA       GACCACTGGTGTCTTGAAGATGGTCAACCTCCAAAGTGGGGGCTTCTCCTGCACCATCAGGTACCGGA       AGATTGGCCCCCTGGTGGACAAGCAGATCTACAGGTTCTCCGAGGAAGGCATGGTCAATGCCAGGTTT       GACTACACCTATCATGACAACAGCTTCCGCATCGCAAGCATCAAGCCCGTCATAAGTGAGACTCCCCT       CCCCGTTGACCTCTACCGCTATGATGAGATTTCTGGCAAGGTGGAACACTTTGGTAAGTTTGGAGTCA       TCTATTATGACATCAACCAGATCATCACCACTGCCGTGATGACCCTCAGCAAACACTTCGACACCCAT       GGGCGGATCAAGGAGGTCCAGTATGAGATGTTCCGGTCCCTCATGTACTGGATGACGGTGCAATATGA       CAGCATGGGCAGGGTGATCAAGAGGGAGCTAAAACTGGGGCCCTATGCCAATACCACGAAGTACACCT       ATGACTACGATGGGGACGGGCAGCTCCAGAGCGTGGCCGTCAATGACCGCCCGACCTGGCGCTACAGC       TATGACCTTAATGGGAATCTCCACTTACTGAACCCAGGCAACAGTGTGCGCCTCATGCCCTTGCGCTA       TGACCTCCGGGATCGGATAACCAGACTCGGGGATGTGCAGTACAAAATTGACGACGATGGCTATCTGT       GCCAGAGAGGGTCTGACATCTTCGAATACAATTCCAAGGGCCTCCTAACAAGAGCCTACAACAAGGCC       AGCGGGTGGAGTGTCCAGTACCGCTATGATGGCGTAGGACGGCGGGCTTCCTACAAGACCAACCTGGG       CCACCACCTGCAGTACTTCTACTCTGACCTCCACAACCCGACGCGCATCACCCATGTCTACAATCACT       CCAACTCGGAGATTACCTCACTGTACTACGACCTCCAGGGCCACCTCTTTGCCATGGAGAGCAGCAGT       GGGGAGGAGTACTATGTTGCCTCTGATAACACAGGGACTCCTCTGGCTGTGTTCAGCATCAACGGCCT       CATGATCAAACAGCTGCAGTACACGGCCTATGGGGAGATTTATTATGACTCCAACCCCGACTTCCAGA       TGGTCATTGGCTTCCATGGGGGACTCTATGACCCCCTGACCAAGCTGGTCCACTTCACTCAGCGTGAT       TATGATGTGCTGGCAGGACGATGGACCTCCCCAGACTATACCATGTGGAAAAACGTGGGCAAGGAGCC       GGCCCCCTTTAACCTGTATATGTTCAAGAGCAACAATCCTCTCAGCAGTGAGCTAGATTTGAAGAACT       ACGTGACAGATGTGAAAAGCTGGCTTGTGATGTTTGGATTTCAGCTTAGCAACATCATTCCTGGCTTC       CCGAGAGCCAAAATGTATTTCGTGCCTCCTCCCTATGAATTGTCAGAGAGTCAAGCAAGTGAGAATGG       ACAGCTCATTACAGGTGTCCAACAGACAACAGAGAGACATAACCAGGCCTTCATGGCTCTGGAAGGAC       AGGTCATTACTAAAAAGCTCCACGCCAGCATCCGAGAGAAAGCAGGTCACTGGTTTGCCACCACCACG       CCCATCATTGGCAAAGGCATCATGTTTGCCATCAAAGAAGGGCGGGTGACCACGGGCGTGTCCAGCAT       CGCCAGCGAAGATAGCCGCAAGGTGGCATCTGTGCTGAACAACGCCTACTACCTGGACAAGATGCACT       ACAGCATCGAGGGCAAGGACACCCACTACTTTGTGAAGATTGGCTCAGCCGATGGCGACCTGGTCACA       CTAGGCACCACCATCGGCCGCAAGGTGCTAGAGAGCGGGGTGAACGTGACCGTGTCCCAGCCCACGCT       GCTGGTCAACGGCAGGACTCGAAGGTTCACGAACATTGAGTTCCAGTACTCCACGCTGCTGCTCAGCA       TCCGCTATGGCCTCACCCCCGACACCCTGGACGAAGAGAAGGCCCGCGTCCTGGACCAGGCGAGACAG       AGGGCCCTGGGCACGGCCTGGGCCAAGGAGCAGCAGAAAGCCAGGGACGGGAGAGAGGGGAGCCGCCT       GTGGACTGAGGGCGAGAAGCAGCAGCTTCTGAGCACCGGGCGCGTGCAAGGGTACGAGGGATATTACG       TGCTTCCCGTGGAGCAATACCCAGAGCTTGCAGACAGTAGCAGCAACATCCAGTTTTTAAGACAGAAT       GAGATGGGAAAGAGGTAACAAAA TAA   TCTGCTGCCATTCCTTGTCTGAATGGCTCAGCAGGAGTAACT                                                   NOV7a, CG50426-17   SEQ ID NO: 114   2662 aa   MW at 295881.9kD               Protein Sequence                     MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRE           SDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGI       KSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSN       TSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNR       NSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLT       SGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKNSSIDSG       EAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEK       WSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGE       CVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCID       GNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTG       LCSCDPNWMGPDCSVDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLV       DCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSL       VSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERTVWL       PWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIELPG       SNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLASTFIWDKTDAY       GQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILHKGTGE       NQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFNYIRRIFPSRNV       TSILELRNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQC       LPFDEARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCD       SSMDVAQVRLEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHS       ALESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKIWVNCNCYSGDDAYATD       AILNSPSSLAVAPDGTIYIADLGNIRIEAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSL       VTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQNLE       LGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDV       TVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPM       ENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPF       LWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQ       RQYIFEYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLGTGR       QVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSEEGM       VNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSK       HFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRP       TWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTR       AYNKASGWSVQYRYDGVGRPASYKTNLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFA       MESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVH       FTQRDYDVLAGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSN       IIPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASIREKAGHW       FATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKDTHYFVKIGSAD       GDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYSTLLLSIRYGLTPDTLDEEKARVL       DQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQ       FLRQNEMGKR                                             NOV7b, CG50426-21   SEQ ID NO: 115   9852 bp               DNA Sequence   ORF Start: ATG at 210   ORF Stop: TAA at 8505                       CCAGCATTAGATGAGTTGACAAAAATGCAGTTTCAGCTCTGAAGGTCTGAAAGATTCTGCTGCAACTA               AAGCTCTGAAGATTCTGCTACAACTATGACATCCATTTTCTCCCACTTCAGACAGGATGAATACAAGG           TGGCAAAGTGACAAGTGCCAAAACTCAGGCCTGACTTTCCTGAAAACATCAGCATTCTGCCATATCTG           GAATA   ATG GATGTAAAGGACCGGCGACACCGCTCTTTGACCAGAGGACGCTGTGGCAAAGAGTGTCGC       TACACAAGCTCCTCTCTGGACAGTGAGGACTGCCGGGTGCCCACACAGAAATCCTACAGCTCCAGTGA       GACTCTGAAGGCCTATGACCATGACAGCAGGATGCACTATGGAAACCGAGTCACAGACCTCATCCACC       GGGAGTCAGATGAGTTTCCTAGACAAGGAACCAACTTCACCCTTGCCGAACTGGGCATCTGTGAGCCC       TCCCCACACCGAAGCGGCTACTGCTCCGACATGGGGATCCTTCACCAGGGCTACTCCCTTAGCACAGG       GTCTGACGCCGACTCCGACACCGAGGGAGGGATGTCTCCAGAACACGCCATCAGACTGTGGGGCAGAG       GGATAAAATCCAGGCGCAGTTCCGGCCTGTCCAGTCGTGAAAACTCGGCCCTTACCCTGACTGACTCT       GACAACGAAAACAAATCAGATGATGAGAACGGTCGTCCCATTCCACCTACATCCTCGCCTAGTCTCCT       CCCATCTGCTCAGCTGCCTAGCTCCCATAATCCTCCACCAGTTAGCTGCCAGATGCCATTGCTAGACA       GCAACACCTCCCATCAAATCATGGACACCAACCCTGATGAGGAATTCTCCCCCAATTCATACCTGCTC       AGAGCATGCTCAGGGCCCCAGCAAGCCTCCAGCAGTGGCCCTCCGAACCACCACAGCCAGTCGACTCT       GAGGCCCCCTCTCCCACCCCCTCACAACCACACGCTGTCCCATCACCACTCGTCCGCCAACTCCCTCA       ACAGGAACTCACTGACCAATCGGCGGAGTCAGATCCACGCCCCGGCCCCAGCGCCCAATGACCTGGCC       ACCACACCAGAGTCCGTTCAGCTTCAGGACAGCTGGGTGCTAAACAGCAACGTGCCACTGGAGACCCG       GCACTTCCTCTTCAAGACCTCCTCGGGGAGCACACCCTTGTTCAGCAGCTCTTCCCCGGGATACCCTT       TGACCTCAGGAACGGTTTACACGCCCCCGCCCCGCCTGCTGCCCAGGAATACTTTCTCCAGGAAGGCT       TTCAAGCTGAAGAAGCCCTCCAAATACTGCAGCTGGAAATGTGCTGCCCTCTCCGCCATTGCCGCGGC       CCTCCTCTTGGCTATTTTGCTGGCGTATTTCATAGCAATGCATCTGCTCGGACTCAATTGGCAACTCC       AGCCTGCAGATGGGCACACCTTTAACAATGGGATAAGGACCGGCTTACCAGGAAACGATGATGTGGCA       ACAATGCCATCTGGAGGCAAAGTGCCCTGGTCGTTGAAAAACAGCAGCATAGACAGTGGTGAAGCAGA       AGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGGGGTGTTTTGGAGGTCACAAATTCACATCAGTC       AGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGAAGGACGCTCTCTTTGGTGTTTACATAAGAAGA       GGACTTCCACCATCTCATGCCCAGTATGACTTCATGGAACGTCTGGACGGGAAGGAGAAGTGGAGTGT       GGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGACCTTGGTTCAGAATGAAGCCGTGTTTGTGCAGT       ACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACAATGATGGAAAAGACAAAGAGATGGTTTCCTTC       AATACTGTTGTCCTAGATTCAGTGCAGGACTGTCCACGTAACTGCCATGGGAATGGTGAATGTGTGTC       CGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGCAGACTGTGCTAAAGCTGCCTGCCCTGTCCTGT       GCAGTGGGAATGGACAATATTCTAAAGGGACGTGCCAGTGCTACAGCGGCTGGAAAGGTGCAGAGTGC       GACGTGCCCATGAATCAGTGCATCGATCCTTCCTGCGGGGGCCACGGCTCCTGCATTGATGGGAACTG       TGTCTGCTCTGCTGGCTACAAAGGCGAGCACTGTGAGGAAGTTGATTGCTTGGATCCCACCTGCTCCA       GCCACGGAGTCTGTGTGAATGGAGAATGCCTGTGCAGCCCTGGCTGGGGTGGTCTGAACTGTGAGCTG       GCGAGGGTCCAGTGCCCAGACCAGTGCAGTGGGCATGGCACGTACCTGCCTGACACGGGCCTCTGCAG       CTGCGATCCCAACTGGATGGGTCCCGACTGCTCTGTTGAAGTGTGCTCAGTAGACTGTGGCACTCACG       GCGTCTGCATCGGGGGAGCCTGCCGCTGTGAAGAGGGCTGGACAGGCGCAGCGTGTGACCAGCGCGTG       TGCCACCCCCGCTGCATTGAGCATGGGACCTGTAAAGATGGCAAATGTGAATGCCGAGAGGGCTGGAA       TGGTGAACACTGCACCATTGATGGCTGCCCTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGTC       AGAACAGCTGGCAGTGTGTCTGCCAGACCGGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAACT       TCCTGTGCTGATAACAAGGATAATGAGGGAGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCCT       GCAGTCAGCCTGTCAGAACAGCCTGCTCTGCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAGG       GCCAGACGGATTGGCCCGCAGTGAAGTCCTTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAGC       ACCCACATCATTCCTGGAGAGAACCCTTTCAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAGT       AACTACAGATGGAACTCCCCTGGTCGGTGTGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTACA       CCATCACCCGCCAGGATGGCACGTTCGACCTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTTT       GAGCGAGCCCCGTTCATGAGCCAGGAGCGCACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGGA       CACCCTGGTGATGAAGACCGAGGAGAACTCCATCCCCAGCTGTGACCTCAGTGGCTTTGTCCGGCCTG       ATCCAATCATCATCTCCTCCCCACTGTCCACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGTG       CCTGAGACCCAGGTTCTTCATGAAGAAATCGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGAG       CTCTAGAACTGCAGGGTACAAGTCACTGCTGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAACC       TCATTAGGGTTCACCTGATGGTGGCTGTCGAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCCC       AACCTGGCCTCCACCTTCATCTGGGACAAGACAGATGCGTATGGCCAAAGGGTGTATGGACTCTCAGA       TGCTGTTGTGTCTGTCGGGTTTGAATATGAGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACAG       CCCTCCTTCAGGGATTCGAGCTGGACCCCTCCAACCTCGGTGGCTGGTCCCTAGACAAACACCACATC       CTCAATGTTAAAAGTGGAATCCTACACAAAGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTGC       CATCATCACCAGCATCATGGGCAATGGTCGCCGCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTTG       CTGAAGGCAACAAGCTGCTGGCCCCAGTGGCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGGT       GACTTCAATTACATCCGACGCATCTTTCCCTCTCGAAATGTGACCAGCATCTTGGAGTTACGAAATAA       AGAGTTTAAACATAGCAACAACCCAGCACACAAGTACTACTTGGCAGTGGACCCCGTGTCCGGCTCGC       TCTACGTGTCCGACACCAACAGCAGGAGAATCTACCGCGTCAAGTCTCTGAGTGGAACCAAAGACCTG       GCTGGGAATTCGGAAGTTGTGGCAGGGACGGGAGAGCAGTGTCTACCCTTTGATGAAGCCCGCTGCGG       GGATGGAGGGAAGGCCATAGATGCAACCCTGATGAGCCCGAGAGGTATTGCAGTAGACAAGAATGGGC       TCATGTACTTTGTCGATGCCACCATGATCCGGAAGGTTGACCAGAATGGAATCATCTCCACCCTGCTG       GGCTCCAATGACCTCACTGCCGTCCGGCCGCTGAGCTGTGATTCCAGCATGGATGTAGCCCAGGTTCG       TCTGGAGTGGCCAACAGACCTTGCTGTCAATCCCATGGATAACTCCTTGTATGTTCTAGAGAACAATG       TCATCCTTCGAATCACCGAGAACCACCAAGTCAGCATCATTGCGGGACGCCCCATGCACTGCCAAGTT       CCTGGCATTGACTACTCACTCAGCAAACTAGCCATTCACTCTGCCCTGGAGTCAGCCAGTGCCATTGC       CATTTCTCACACTGGGGTCCTCTACATCACTGAGACAGATGAGAAGAAGATTAACCGTCTACGCCAGG       TAACAACCAACGGGGAGATCTGCCTTTTAGCTGGGGCAGCCTCGGACTGCGACTGCAAAAACGATGTC       AATTGCAACTGCTATTCAGGAGATGATGCCTACGCGACTGATGCCATCTTGAATTCCCCATCATCCTT       AGCTGTAGCTCCAGATGGTACCATTTACATTGCAGACCTTGGAAATATTCGGATCAGGGCGGTCAGCA       AGAACAAGCCTGTTCTTAATGCCTTCAACCAGTATGAGGCTGCATCCCCCGGAGAGCAGGAGTTATAT       GTTTTCAACGCTGATGGCATCCACCAATACACTGTGAGCCTGGTGACAGGGGAGTACTTGTACAATTT       CACATATAGTACTGACAATGATGTCACTGAATTGATTGACAATAATGGGAATTCCCTGAAGATCCGTC       GGGACAGCAGTGGCATGCCCCGTCACCTGCTCATGCCTGACAACCAGATCATCACCCTCACCGTGGGC       ACCAATGGAGGCCTCAAAGTCGTGTCCACACAGAACCTGGAGCTTGGTCTCATGACCTATGATGGCAA       CACTGGGCTCCTGGCCACCAAGAGCGATGAAACAGGATGGACGACTTTCTATGACTATGACCACGAAG       GCCGCCTGACCAACGTGACGCGCCCCACGGGGGTGGTAACCAGTCTGCACCGGGAAATGGAGAAATCT       ATTACCATTGACATTGAGAACTCCAACCGTGATGATGACGTCACTGTCATCACCAACCTCTCTTCAGT       AGAGGCCTCCTACACAGTGGTACAAGATCAAGTTCGGAACAGCTACCAGCTCTGTAATAATGGTACCC       TGAGGGTGATGTATGCTAATGGGATGGGTATCAGCTTCCACAGCGAGCCCCATGTCCTAGCGGGCACC       ATCACCCCCACCATTGGACGCTGCAACATCTCCCTGCCTATGGAGAATGGCTTAAACTCCATTGAGTG       GCGCCTAAGAAAGGAACAGATTAAAGGCAAAGTCACCATCTTTGGCAGGAAGCTCCGGGTCCATGGAA       GAAATCTCTTGTCCATTGACTATGATCGAAATATTCGGACTGAAAAGATCTATGATGACCACCGGAAG       TTCACCCTGAGGATCATTTATGACCAGGTGGGCCGCCCCTTCCTCTGGCTGCCCAGCAGCGGGCTGGC       AGCTGTCAACGTGTCATACTTCTTCAATGGGCGCCTGGCTGGGCTTCAGCGTGGGGCCATGAGCGAGA       GGACAGACATCGACAAGCAAGGCCGCATCGTGTCCCGCATGTTCGCTGACGGGAAAGTGTGGAGCTAC       TCCTACCTTGACAAGTCCATGGTCCTCCTGCTTCAGAGCCAACGTCAGTATATATTTGAGTATGACTC       CTCTGACCGCCTCCTTGCCGTCACCATGCCCAGCGTGGCCCGGCACAGCATGTCCACACACACCTCCA       TCGGCTACATCCGTAATATTTACAACCCGCCTGAAAGCAATGCTTCGGTCATCTTTGACTACAGTGAT       GACGGCCGCATCCTGAAGACCTCCTTTTTGGGCACCGGACGCCAGGTGTTCTACAAGTATGGGAAACT       CTCCAAGTTATCAGAGATTGTCTACGACAGTACCGCCGTCACCTTCGGGTATGACGAGACCACTGGTG       TCTTGAAGATGGTCAACCTCCAAAGTGGGGGCTTCTCCTGCACCATCAGGTACCGGAAGATTGGCCCC       CTGGTGGACAAGCAGATCTACAGGTTCTCCGAGGAAGGCATGGTCAATGCCAGGTTTGACTACACCTA       TCATGACAACAGCTTCCGCATCGCAAGCATCAAGCCCGTCATAAGTGAGACTCCCCTCCCCGTTGACC       TCTACCGCTATGATGAGATTTCTGGCAAGGTGGAACACTTTGGTAAGTTTGGAGTCATCTATTATGAC       ATCAACCAGATCATCACCACTGCCGTGATGACCCTCAGCAAACACTTCGACACCCATGGGCGGATCAA       GGAGGTCCAGTATGAGATGTTCCGGTCCCTCATGTACTGGATGACGGTGCAATATGACAGCATGGGCA       GGGTGATCAAGAGGGAGCTAAAACTGGGGCCCTATGCCAATACCACGAAGTACACCTATGACTACGAT       GGGGACGGGCAGCTCCAGAGCGTGGCCGTCAATGACCGCCCGACCTGGCGCTACAGCTATGACCTTAA       TGGGAATCTCCACTTACTGAACCCAGGCAACAGTGTGCGCCTCATGCCCTTGCGCTATGACCTCCGGG       ATCGGATAACCAGACTCGGGGATGTGCAGTACAAAATTGACGACGATGGCTATCTGTGCCAGAGAGGG       TCTGACATCTTCGAATACAATTCCAAGGGCCTCCTAACAAGAGCCTACAACAAGGCCAGCGGGTGGAG       TGTCCAGTACCGCTATGATGGCGTAGGACGGCGGGCTTCCTACAAGACCAACCTGGGCCACCACCTGC       AGTACTTCTACTCTGACCTCCACAACCCGACGCGCATCACCCATGTCTACAATCACTCCAACTCGGAG       ATTACCTCACTGTACTACGACCTCCAGGGCCACCTCTTTGCCATGGAGAGCAGCAGTGGGGAGGAGTA       CTATGTTGCCTCTGATAACACAGGGACTCCTCTGGCTGTGTTCAGCATCAACGGCCTCATGATCAAAC       AGCTGCAGTACACGGCCTATGGGGAGATTTATTATGACTCCAACCCCGACTTCCAGATGGTCATTGGC       TTCCATGGGGGACTCTATGACCCCCTGACCAAGCTGGTCCACTTCACTCAGCGTGATTATGATGTGCT       GGCAGGACGATGGACCTCCCCAGACTATACCATGTGGAAAAACGTGGGCAAGGAGCCGGCCCCCTTTA       ACCTGTATATGTTCAAGAGCAACAATCCTCTCAGCAGTGAGCTAGATTTGAAGAACTACGTGACAGAT       GTGAAAAGCTGGCTTGTGATGTTTGGATTTCAGCTTAGCAACATCATTCCTGGCTTCCCGAGAGCCAA       AATGTATTTCGTGCCTCCTCCCTATGAATTGTCAGAGAGTCAAGCAAGTGAGAATGGACAGCTCATTA       CAGGTGTCCAACAGACAACAGAGAGACATAACCAGGCCTTCATGGCTCTGGAAGGACAGGTCATTACT       AAAAAGCTCCACGCCAGCATCCGAGAGAAAGCAGGTCACTGGTTTGCCACCACCACGCCCATCATTGG       CAAAGGCATCATGTTTGCCATCAAAGAAGGGCGGGTGACCACGGGCGTGTCCAGCATCGCCAGCGAAG       ATAGCCGCAAGGTGGCATCTGTGCTGAACAACGCCTACTACCTGGACAAGATGCACTACAGCATCGAG       GGCAAGGACACCCACTACTTTGTGAAGATTGGCTCAGCCGATGGCGACCTGGTCACACTAGGCACCAC       CATCGGCCGCAAGGTGCTAGAGAGCGGGGTGAACGTGACCGTGTCCCAGCCCACGCTGCTGGTCAACG       GCAGGACTCGAAGGTTCACGAACATTGAGTTCCAGTACTCCACGCTGCTGCTCAGCATCCGCTATGGC       CTCACCCCCGACACCCTGGACGAAGAGAAGGCCCGCGTCCTGGACCAGGCGAGACAGAGGGCCCTGGG       CACGGCCTGGGCCAAGGAGCAGCAGAAAGCCAGGGACGGGAGAGAGGGGAGCCGCCTGTGGACTGAGG       GCGAGAAGCAGCAGCTTCTGAGCACCGGGCGCGTGCAAGGGTACGAGGGATATTACGTGCTTCCCGTG       GAGCAATACCCAGAGCTTGCAGACAGTAGCAGCAACATCCAGTTTTTAAGACAGAATGAGATGGGAAA       GAGG TAA   CAAAATAATCTGCTGCCATTCCTTGTCTGAATGGCTCAGCAGGAGTAACTGTTATCTCCTC           TCCTAAGGAGATGAAGACCTAACAGGGGCACTGCGGCTGGGCTGCTTTAGGAGACCAAGTGGCAAGAA           AGCTCACATTTTTTGAGTTCAAATGCTACTGTCCAAGCGAGAAGTCCCTCATCCTGAAGTAGACTAAA           GCCCGGCTGAAAATTCCGAGGAAAACAAAACAAACGAATGAATGAACAGACACACACAATGTTCCAAC           TTCCCCTAAAATATGACCCACTTGTTCTGGGTCTACGCAGAAAAGAGACGCAAAGTGTCCAAAAGGAA           CAAAAGAACAAAAACGAATAAGCAAAGAAGAAAACAAACAAAAACAAAACAAAACAAACACACGGACC           GATAAACAAAGAAGCGAAGATAAGAAAGAAGGCCTCATATCCAATTACCTCACTCATTCACATGTGAG           CGACACGCAGACATCCGCGAGGGCCAGCGTCACCAGACCAGCTGCGGGACAAACCACTCAGACTGCTT           GTAGGACAAATACTTCTGACATTTTCGTTTAAGCAAATACAGGTGCATTTAAAACACGACTTTGGGGG           TGATTTGTGTGTAGCGCCTGGGGAGGGGGGATAAAAGAGGAGGAGTGAGCACTGGAAATACTTTTTAA           AGAAAAAAAAACATGAGGGAATAAAAGAAATTCCTATCAAAAATCAAAGTGAAATAATACCATCCAGC           ACTTAACTCTCAGGTCCCAACTAAGTCTGGCCTGAGCTAATTTATTTGAGCGCAGAGTGTAAAATTTA           ATTCAAAATGGTGGCTATAATCACTACAGATAAATTTCATACTCTTTTGTCTTTGGAGATTCCATTGT           GGACAGTAATACGCAGTTACAGGGTGTAGTCTGTTTAGATTCCGTAGTTCGTGGGTATCAGTTTCGGT           AGAGGTGCAGCATCGTGACACTTTTGCTAACAGGTACCACTTCTGATCACCCTGTACATACATGAGCC           GAAAGGCACAATCACTGTTTCAGATTTAAAATTATTAGTGTGTTTGTTTGGTCCAGAAACTGAGACAA           TCACATGACAGTCACCACGAGGAGAGAAAATTTAAAAAATAAAAATAAAAACAAAAAAAATTTTAAAA           ATTAAAAAAACAAAAATAAAGTCTAATAAGAACTTTGGTACAGGAACTTTTTTGTAATATACATGTAT           GAATTGTTCATCGAGTTTTTATATTAATTTTAATTTGCTGCTAAGCAAAGACTAGGGACAGGCAAAGA           TAATTTATGGCAAAGTGTTTAAATTGTTTATACATAAATAAAGTCTCTAAAACTCCTGTG                                                   NOV7b, CG50426-21   SEQ ID NO: 116   2765 aa   MW at 306806.1kD               Protein Sequence                     MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRE           SDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGI       KSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSN       TSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNR       NSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLT       SGIVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIAMHLLGLNWQLQP       ADGHTFNNGIRTGLPGNDDVATMPSGGKVPWSLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQP       QFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYL       DVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCS       GNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSH       GVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGV       CIGGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIDGCPDLCNGNGRCTLGQN       SWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQ       TDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTI       TRQDGTFDLIANGGASLTLHFERAPFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDP       IIISSPLSTFFSAAPGQNPIVPETQVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLI       RVHLMVAVEGHLFQKSFQASPNLASTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTAL       LQGFELDPSNLGGWSLDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAE       GNKLLAPVALAVGIDGSLYVGDFNYIRRIFPSRNVTSILELRNKEFKHSNNPAHKYYLAVDPVSGSLY       VSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDATLMSPRGIAVDKNGLM       YFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLENNVI       LRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSALESASAIAISHTGVLYITETDEKKINRLRQVT       TNGEICLLAGAASDCDCKNDVNCNCYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKN       KPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRD       SSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGR       LTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLR       VMYANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRN       LLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERT       DIDKQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQRQYIFEYDSSDRLLAVTMPSVARHSMSTHTSIG       YIRNIYNPPESNASVIFDYSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVL       KMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSEEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLY       RYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRV       IKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDR       ITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGWSVQYRYDGVGRRASYKTNLGHHLQY       FYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQL       QYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDYTMWKNVGKEPAPFNL       YMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNIIPGFPRAKMYFVPPPYELSESQASENGQLITG       VQQTTERHNQAFMALEGQVITKKLHASIREKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDS       RKVASVLNNAYYLDKMHYSIEGKDTHYFVKIGSADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGR       TRRFTNIEFQYSTLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGE       IKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR                                             NOV7c, CG50426-15   SEQ ID NO: 117   2478 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     AAAAACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGG           GGTGTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGA       AGGACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTATGACTTCATG       GAACGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGAC       CTTGGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACA       ATGATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCAGGACTGTCCA       CGTAACTGCCATGGGAATGGTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGC       AGACTGTGCTAAAGCTGCCTGCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAAGGGACGTGCC       AGTGCTACAGCGGCTGGAAAGGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGATCCTTCCTGC       GGGGGCCACGGCTCCTGCATTGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCGAGCACTGTGA       GGAAGTTGATTGCTTGGATCCCACCTGCTCCAGCCACGGAGTCTGTGTGAATGGAGAATGCCTGTGCA       GCCCTGGCTGGGGTGGTCTGAACTGTGAGCTGGCGAGGGTCCAGTGCCCAGACCAGTGCAGTGGGCAT       GGCACGTACCTGCCTGACACGGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCGACTGCTCTGT       TGAAGTGTGCTCAGTAGACTGTGGCACTCACGGCGTCTGCATCGGGGGAGCCTGCCGCTGTGAAGAGG       GCTGGACAGGCGCAGCGTGTGACCAGCGCGTGTGCCACCCCCGCTGCATTGAGCACGGGACCTGTAAA       GATGGCAAATGTGAATGCCGAGAGGGCTGGAATGGTGAACACTGCACCATTGGTAGGCAAACGGCAGG       CACCGAAACAGATGGCTGCCCTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGTCAGAACAGCT       GGCAGTGTGTCTGCCAGACCGGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAACTTCCTGTGCT       GATAACAAGGATAATGAGGGAGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCCTGCAGTCAGC       CTGTCAGAACAGCCTGCTCTGCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAGGGCCAGACGG       ATTGGCCCGCAGTGAAGTCCTTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAGCACCCACATC       ATTCCTGGAGAGAACCCTTTCAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAGTAACTACAGA       TGGAACTCCCCTGGTCGGTGTGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTACACCATCACCC       GCCAGGATGGCACGTTCGACCTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTTTGAGCGAGCC       CCGTTCATGAGCCAGGAGCGCACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGGACACCCTGGT       GATGAAGACCGAGGAGAACTCCATCCCCAGCTGTGACCTCAGTGGCTTTGTCCGGCCTGATCCAATCA       TCATCTCCTCCCCACTGTCCACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGTGCCTGAGACC       CAGGTTCTTCATGAAGAAATCGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGAGCTCTAGAAC       TGCAGGGTACAAGTCACTGCTGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAACCTCATTAGGG       TTCACCTGATGGTGGCTGTCGAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCCCAACCTGGCC       TCCACCTTCATCTGGGACAAGACAGATGCGTATGGCCAAAGGGTGTATGGACTCTCAGATGCTGTTGT       GTCTGTCGGGTTTGAATATGAGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACAGCCCTCCTTC       AGGGATTCGAGCTGGACCCCTCCAACCTCGGTGGCTGGTCCCTAGACAAACACCACATCCTCAATGTT       AAAAGTGGAATCCTACACAAAGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTGCCATCATCAC       CAGCATCATGGGCAATGGTCGCCGCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTTGCTGAAGGCA       ACAAGCTGCTGGCCCCAGTGGCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGGTGACTTCAAT       TACATCCGACGCATCTTTCCCTCTCGAAAT                                                 NOV7c, CG50426-15   SEQ ID NO: 118   826 aa   MW at 89833.6kD               Protein Sequence                     KNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFM           ERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCP       RNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSC       GGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGH       GTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCK       DGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCA       DNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHI       IPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERA       PFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPET       QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLA       STFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNV       KSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFN       YIRRIFPSRN                                             NOV7d, 306276924   SEQ ID NO: 119   2497 bp               DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAAGCTTAAAAACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAG           TCCCACCAGGGGTGTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATC       TCCCTCGGGAAGGACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTA       TGACTTCATGGAACGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGA       GCATACAGACCTTGGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTG       GCCTTCTACAATGATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCA       GGACTGTCCACGTAACTGCCATGGGAATGGTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGAT       TTCTAGGAGCAGACTGTGCTAAAGCTGCCTGCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAA       GGGACGTGCCAGTGCTACAGCGGCTGGAAAGGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGA       TCCTTCCTGCGGGGGCCACGGCTCCTGCATTGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCG       AGCACTGTGAGGAAGTTGATTGCTTGGATCCCACCTGCTCCAGCCACGGAGTCTGTGTGAATGGAGAA       TGCCTGTGCAGCCCTGGCTGGGGTGGTCTGAACTGTGAGCTGGCGAGGGTCCAGTGCCCAGACCAGTG       CAGTGGGCATGGCACGTACCTGCCTGACACGGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCG       ACTGCTCTGTTGAAGTGTGCTCAGTAGACTGTGGCACTCACGGCGTCTGCATCGGGGGAGCCTGCCGC       TGTGAAGAGGGCTGGACAGGCGCAGCGTGTGACCAGCGCGTGTGCCACCCCCGCTGCATTGAGCACGG       GACCTGTAAAGATGGCAAATGTGAATGCCGAGAGGGCTGGAATGGTGAACACTGCACCATTGGTAGGC       AAACGGCAGGCACCGAAACAGATGGCTGCCCTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGT       CAGAACAGCTGGCAGTGTGTCTGCCAGACCGGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAAC       TTCCTGTGCTGATAACAAGGATAATGAGGGAGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCC       TGCAGTCAGCCTGTCAGAACAGCCTGCTCTGCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAG       GGCCAGACGGATTGGCCCGCAGTGAAGTCCTTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAG       CACCCACATCATTCCTGGAGAGAACCCTTTCAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAG       TAACTACAGATGGAACTCCCCTGGTCGGTGTGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTAC       ACCATCACCCGCCAGGATGGCACGTTCGACCTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTT       TGAGCGAGCCCCGTTCATGAGCCAGGAGCGCACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGG       ACACCCTGGTGATGAAGACCGAGGAGAACTCCATCCCCAGCTGTGACCTCAGTGGCTTTGTCCGGCCT       GATCCAATCATCATCTCCTCCCCACTGTCCACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGT       GCCTGAGACCCAGGTTCTTCATGAAGAAATCGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGA       GCTCTAGAACTGCAGGGTACAAGTCACTGCTGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAAC       CTCATTAGGGTTCACCTGATGGTGGCTGTCGAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCC       CAACCTGGCCTACACCTTCATCTGGGACAAGACAGATGCGTATGGCCAAAGGGTGTATGGACTCTCAG       ATGCTGTTGTGTCTGTCGGGTTTGAATATGAGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACA       GCCCTCCTTCAGGGATTCGAGCTGGACCCCTCCAACCTCGGTGGCTGGTCCCTAGACAAACACCACAT       CCTCAATGTTAAAAGTGGAATCCTACACAAAGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTG       CCATCATCACCAGCATCATGGGCAATGGTCGCCGCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTT       GCTGAAGGCAACAAGCTGCTGGCCCCAGTGGCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGG       TGACTTCAATTACATCCGACGCATCTTTCCCTCTCGAAATCTCGAGGGC                                                 NOV7d, 306276924   SEQ ID NO: 120   832 aa   MW at 90551.4kD               Protein Sequence                 TKLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQY           DFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQ       DCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCID       PSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQC       SGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHG       TCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMET       SCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDS       THIIPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHF       ERAPFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIV       PETQVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASP       NLAYTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHI       LNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVG       DFNYIRRIFPSRNLEG                                             NOV7e, 306276936   SEQ ID NO: 121   2470 bp               DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAAGCTTAAAAACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAG           TCCCACCAGGGGTGTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATC       TCCCTCGGGAAGGACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTA       TGACTTCATGGAACGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGA       GCATACAGACCTTGGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTG       GCCTTCTACAATGATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCA       GGACTGTCCACGTAACTGCCATGGGAATGGTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGAT       TTCTAGGAGCAGACTGTGCTAAAGCTGCCTGCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAA       GGGACGTGCCAGTGCTACAGCGGCTGGAAAGGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGA       TCCTTCCTGCGGGGGCCACGGCTCCTGCATTGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCG       AGCACTGTGAGGAAGTTGATTGCTTGGATCCCACCTGCTCCAGCCACGGAGTCTCTGTGAATGGAGAA       TGCCTGTGCAGCCCTGGCTGGGGTGGTCTGAACTGTGAGCTGGCGAGGGTCCAGTGCCCAGACCAGTG       CAGTGGGCATGGCACGTACCTGCCTGACACGGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCG       ACTGCTCTGTTGAAGTGTGCTCAGTAGACTGTGGCACTCACGGCGTCTGCATCGGGGGAGCCTGCCGC       TGTGAAGAGGGCTGGACAGGCGCAGCGTGTGACCAGCGCGTGTGCCACCCCCGCTGCATTGAGCACGG       GACCTGTAAAGATGGCAAATGTGAATGCCGAGAGGGCTGGAATGGTGAACACTGCACCATTGATGGCT       GCCCTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGTCAGAACAGCTGGCAGTGTGTCTGCCAG       ACCGGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAACTTCCTGTGCTGATAACAAGGATAATGA       GGGAGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCCTGCAGTCAGCCTGTCAGAACAGCCTGC       TCTGCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAGGGCCAGACGGATTGGCCCGCAGTGAAG       TCCTTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAGCACCCACATCATTCCTGGAGAGAACCC       TTTCAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAGTAACTACAGATGGAACTCCCCTGGTCG       GTGTGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTACACCATCACCCGCCAGGATGGCACGTTC       GACCTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTTTGAGCGAGCCCCGTTCATGAGCCAGGA       GCGCACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGGACACCCTGGTGATGAAGACCGAGGAGA       ACTCCATCCCCAGCTGTGACCTCAGTGGCTTTGTCCGGCCTGATCCAATCATCATCTCCTCCCCACTG       TCCACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGTGCCTGAGACCCAGGTTCTTCATGAAGA       AATCGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGAGCTCTAGAACTGCAGGGTACAAGTCAC       TGCTGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAACCTCATTAGGGTTCACCTGATGGTGGCT       GTCGAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCCCAACCTGGCCTACACCTTCATCTGGGA       CAAGACAGATGCGTATGGCCAAAGGGTGTATGGACTCTCAGATGCTGTTGTGTCTGTCGGGTTTGAAT       ATGAGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACAGCCCTCCTTCAGGGATTCGAGCTGGAC       CCCTCCAACCTCGGTGGCTGGTCCCTAGACAAACACCACATCCTCAATGTTAAAAGTGGAATCCTACA       CAAAGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTGCCATCATCACCAGCATCATGGGCAATG       GTCGCCGCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTTGCTGAAGGCAACAAGCTGCTGGCCCCA       GTGGCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGGTGACTTCAATTACATCCGACGCATCTT       TCCCTCTCGAAATCTCGAGGGC                                                 NOV7e, 306276936   SEQ ID NO: 122   823 aa   MW at 89649.5kD               Protein Sequence                     TKLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQY           DFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQ       DCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCID       PSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQC       SGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHG       TCKDGKCECREGWNGEHCTIDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNE       GDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLEAGKDSTHIIPGENP       FNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQE       RTVWLPWNSFYAMDTLVMXTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEE       IELPGSNVKLRYLSSRTAGYKSLLKITNTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLAYTFIWD       KTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILH       KGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFNYIRRIF       PSRNLEG                                             NOV7f, 308530526   SEQ ID NO: 123   2470 bp               DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAAGCTTAAAAACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAG           TCCCACCAGGGGTGTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATC       TCCCTCGGGAAGGACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTA       TGACTTCATGGAACGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGA       GCATACAGACCTTGGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTG       GCCTTCTACAATGATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCA       GGACTGTCCACGTAACTGCCATGGGAATGGTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGAT       TTCTAGGAGCAGACTGTGCTAAAGCTGCCTGCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAA       GGGACGTGCCAGTGCTACAGCGGCTGGAAAGGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGA       TCCTTCCTGCGGGGGCCACGGCTCCTGCATTGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCG       AGCACTGTGAGGAAGTTGATTGCTTGGATCCCACCTGCTCCAGCCACGGAGTCTGTGTGAATGGAGAA       TGCCTGTGCAGCCCTGGCTGGGGTGGTCTGAACTGTGAGCTGGCGAGGGTCCAGTGCCCAGACCAGTG       CAGTGGGCATGGCACGTACCTGCCTGACACAGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCG       ACTGCTCTGTTGAAGTGTGCTCAGTAGACTGTGGCACTCACGGCGTCTGCATCGGGGGAGCCTGCCGC       TGTGAAGAGGGCTGGACAGGCGCAGCGTGTGACCAGCGCGTGTGCCACCCCCGCTGCATTGAGCATGG       GACCTGTAAAGATGGCAAATGTGAATGCCGAGAGGGCTGGAATGGTGAACACTGCACCATTGATGGCT       GCCCTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGTCAGAACAGCTGGCAGTGTGTCTGCCAG       ACCGGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAACTTCCTGTGCTGATAACAAGGATAATGA       GGGAGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCCTGCAGTCAGCCTGTCAGAACAGCCTGC       TCTGCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAGGGCCAGACGGATTGGCCCGCAGTGAAG       TCCTTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAGCACCCACATCATTCCTGGAGAGAACCC       TTTCAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAGTAACTACAGATGGAACTCCCCTGGTCG       GTGTGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTACACCATCACCCGCCAGGATGGCACGTTC       GACCTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTTTGAGCGAGCCCCGTTCATGAGCCAGGA       GCGCACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGGACACCCTGGTGATGAAGACCGAGGAGA       ACTCCATCCCCAGCTGTGACCTCAGTGGCTTTGTCCGGCCTGATCCAATCATCATCTCCTCCCCACTG       TCCACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGTGCCTGAGACCCAGGTTCTTCATGAAGA       AATCGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGAGCTCTAGAACTGCAGGGTACAAGTCAC       TGCTGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAACCTCATTAGGGTTCACCTGATGGTGGCT       GTCGAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCCCAACCTGGCCTACACCTTCATCTGGGA       CAAGACAGATGCGTATGGCCAAAGGGTGTATGGACTCTCAGATGCTGTTGTGTCTGTCGGGTTTGAAT       ATGAGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACAGCCCTCCTTCAGGGATTCGAGCTGGAC       CCCTCCAACCTCGGTGGCTGGTCCCTAGACAAACACCACATCCTCAATGTTAAAAGTGGAATCCTACA       CAAAGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTGCCATCATCACCAGCATCATGGGCAATG       GTCGCCGCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTTGCTGAAGGCAACAAGCTGCTGGCCCCA       GTGGCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGGTGACTTCAATTACATCCGACGCATCTT       TCCCTCTCGAAATCTCGAGGGC                                                 NOV7f, 308530526   SEQ ID NO: 124   823 aa   MW at 89649.5kD               Protein Sequence                     TKLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQY           DFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQ       DCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCID       PSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQC       SGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHG       TCKDGKCECREGWNGEHCTIDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNE       GDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENP       FNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQE       RTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEE       IELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLAYTFIWD       KTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILH       KGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFNYIRRIF       PSRNLEG                                             NOV7g, 308530589   SEQ ID NO: 125   2284 bp               DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAAGCTTAAAAACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAG           TCCCACCAGGGGTGTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATC       TCCCTCGGGAAGGACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTA       TGACTTCATGGAACGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGA       GCATACAGACCTTGGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTG       GCCTTCTACAATGATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCA       GGACTGTCCACGTAACTGCCATGGGAATGGTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGAT       TTCTAGGAGCAGACTGTGCTAAAGCTGCCTGCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAA       GGGACGTGCCAGTGCTACAGCGGCTGGAAAGGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGA       TCCTTCCTGCGGGGGCCACGGCTCCTGCATTGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCG       AGCACTGTGAGGAAGTTGATTGCTTGGATCCCACCTGCTCCAGCCACGGAGTCTGTGTGAATGGAGAA       TGCCTGTGCAGCCCTGGCTGGGGTGGTCTGAACTGTGAGCTGGCGAGGGTCCAGTGCCCAGACCAGTG       CAGTGGGCATGGCACGTACCTGCCTGACACGGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCG       ACTGCTCTGTTGATGGCTGCCCTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGTCAGAACAGC       TGGCAGTGTGTCTGCCAGACCGGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAACTTCCTGTGC       TGATAACAAGGATAATGAGGGAGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCCTGCAGTCAG       CCTGTCAGAACAGCCTGCTCTGCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAGGGCCAGACG       GATTGGCCCGCAGTGAAGTCCTTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAGCACCCACAT       CATTCCTGGAGAGAACCCTTTCAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAGTAACTACAG       ATGGAACTCCCCTGGTCGGTGTGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTACACCATCACC       CGCCAGGATGGCACGTTCGACCTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTTTGAGCGAGC       CCCGTTCATGAGCCAGGAGCGCACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGGACACCCTGG       TGATGAAGACCGAGGAGAACTCCATCCCCAGCTGTGACCTCAGTGGCTTTGTCCGGCCTGATCCAATC       ATCATCTCCTCCCCACTGTCCACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGTGCCTGAGAC       CCAGGTTCTTCATGAAGAAATCGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGAGCTCTAGAA       CTGCAGGGTACAAGTCACTGCTGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAACCTCATTAGG       GTTCACCTGATGGTGGCTGTCGAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCCCAACCTGGC       CTACACCTTCATCTGGGACAAGACAGATGCGTATGGCCAAAGGGTGTATGGACTCTCAGATGCTGTTG       TGTCTGTCGGGTTTGAATATGAGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACAGCCCTCCTT       CAGGGATTCGAGCTGGACCCCTCCAACCTCGGTGGCTGGTCCCTAGACAAACACCACATCCTCAATGT       TAAAAGTGGAATCCTACACAAAGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTGCCATCATCA       CCAGCATCATGGGCAATGGTCGCCGCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTTGCTGAAGGC       AACAAGCTGCTGGCCCCAGTGGCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGGTGACTTCAA       TTACATCCGACGCATCTTTCCCTCTCGAAATCTCGAGGGC                                                 NOV7g, 308530589   SEQ ID NO: 126   761 aa   MW at 83010.1kD               Protein Sequence                     TKLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQY           DFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQ       DCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCID       PSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQC       SGHGTYLPDTGLCSCDPNWMGPDCSVDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCA       DNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHI       IPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERA       PFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPET       QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLA       YTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNV       KSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFN       YIRRIFPSRNLEG                                             NOV7h, CG50426-01   SEQ ID NO: 127   1431 bp               DNA Sequence   ORF Start: ATG at 69   ORF Stop: TAG at 1212                       AAAAAAGGCGGGGGGTGGACTTAGCAGTGTAATTTGAGACCGGTGGTAAGGATTGGAGCGAGCTAGAG               ATG CTGCACGCTGCTAACAAGGGAAGGAAGCCTTCAGCTGAGGCAGGTCGTCCCATTCCACCTACATC       CTCGCCTAGTCTCCTCCCATCTGCTCAGCTGCCTAGCTCCCATAATCCTCCACCAGTTAGCTGCCAGA       TGCCATTGCTAGACAGCAACACCTCCCATCAAATCATGGACACCAACCCTGATGAGGAATTCTCCCCC       AATTCATACCTGCTCAGAGCATGCTCAGGGCCCCAGCAAGCCTCCAGCAGTGGCCCTCCGAACCACCA       CAGCCAGTCGACTCTGAGGCCCCCTCTCCCACCCCCTCACAACCACACGCTGTCCCATCACCACTCGT       CCGCCAACTCCCTCAACAGGAACTCACTGACCAATCGGCGGAGTCAGATCCACGCCCCGGCCCCAGCG       CCCAATGACCTGGCCACCACACCAGAGTCCGTTCAGCTTCAGGACAGCTGGGTGCTAAACAGCAACGT       GCCACTGGAGACCCGGCACTTCCTCTTCAAGACCTCCTCGGGGAGCACACCCTTGTTCAGCAGCTCTT       CCCCGGGATACCCTTTGACCTCAGGAACGGTTTACACGCCCCCGCCCCGCCTGCTGCCCAGGAATACT       TTCTCCAGGAAGGCTTTCAAGCTGAAGAAGCCCTCCAAATACTGCAGCTGGAAATGTGCTGCCCTCTC       CGCCATTGCCGCGGCCCTCCTCTTGGCTATTTTGCTGGCGTATTTCATAGTGCCCTGGTCGTTGAAAA       ACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGGGGTG       TTTTGGAGGTCACAAATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGAAGGA       CGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTATGACTTCATGGAAC       GTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGACCTTG       GTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACAATGA       TGGAAAAGACAAAGAGATGGTTTCCTTCAATACTGTTGTCCTAGATGGGACCATC TAG   TTGCAGAAAA           ACAAGCTCAGGGCGCCCACTGATTTGACATTATGATTCAGTGCAGGACTGTCCACGTAACTGCCATGG           GAATGGTGAANTGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGCAGACTGTGCTAAA           GACCTTCCTGCCTTGACTTTCTGCAAGACAATCATTAATAAAGCTGCTCTGTAAATACTAAAAAAAAA           ACA                                                   NOV7h, CG50426-01   SEQ ID NO: 128   381 aa   MW at 42017.0kD               Protein Sequence                     MLHAANKGRKPSAEAGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEFSP           NSYLLHACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPA       PNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNT       FSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKNSSIDSGEAEVGRRVTQEVPPGV       FWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPRERRSIQTL       VQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDGTI                                             NOV7i, CG50426-02   SEQ ID NO: 129   1447 bp               DNA Sequence   ORF Start: ATG at 277   ORF Stop: at 1447                       GCTCCAAAGCGAGCTGGGACCGAAGACTCTAGGCTAAGTTATCTATGTAGATGGTGTCAGGGAGCGAA               GCTACTGACCGAGCTGCTGTTACATCCAGCTTTTTAATTGCCTAAGCGGTCTGGGGCTTGCTTCGTCA           TTTGGCTTTGCTGTGGAGCACTCCTGTAAAGCCAGCTGAATTGTACATCGAAGATCCACCCTTTTGGT           GGCAAAGTGACAAGTGCCAAAACTCAGGCCTGACTTTTCTGAAAACATCAGCATTCTGCCATATCTGG           AATA   ATG GATGTAAAGGACCGGCGACACCGCTCTTTGACCAGAGGACGCTGTGGCAAAGAGTGTCGCT       ACACAAGCTCCTCTCTGGACAGTGAGGACTGCCGGGTGCCCACACAGAAATCCTACAGCTCCAGTGAG       ACTCTGAAGGCCTATGACCATGACAGCAGGATGCACTATGGAAACCGAGTCACAGACCTCATCCACCG       GGAGTCAGATGAGTTTCCTAGACAAGGAACCAACTTCACCCTTGCCGAACTGGGCATCTGTGAGCCCT       CCCCACACCGAAGCGGCTACTGCTCCGACATGGGGATCCTTCACCAGGGCTACTCCCTTAGCACAGGG       TCTGACGCCGACTCCGACACCGAGGGAGGGATGTCTCCAGAACACGCCATCAGACTGTGGGGCAGAGG       GATAAAATCCAGGCGCAGTTCCGGCCTGTCCAGTCGTGAAAACTCGGCCCTTACCCTGACTGACTCTG       ACAACGAAAACAAATCAGATGATGAGAACGGTCGTCCCATTCCACCTACATCCTCGCCTAGTCTCCTC       CCATCTGCTCAGCTGCCTAGCTCCCATAATCCTCCACCAGTTAGCTGCCAGATGCCATTGCTAGACAG       CAACACCTCCCATCAAATCATGGACACCAACCCTGATGAGGAATTCTCCCCCAATTCATACCTGCTCA       GAGCATGCTCAGGGCCCCAGCAAGCCTCCAGCAGTGGCCCTCCGAACCACCACAGCCAGTCGACTCTG       AGGCCCCCTCTCCCACCCCCTCACAACCACACGCTGTCCCATCACCACTCGTCCGCCAACTCCCTCAA       CAGGAACTCACTGACCAATCGGCGGAGTCAGATCCACGCCCCGGCCCCAGCGCCCAATGACCTGGCCA       CCACACCAGAGTCCGTTCAGCTTCAGGACAGCTGGGTGCTAAACAGCAACGTGCCACTGGAGACCCGG       CACTTCCTCTTCAAGACCTCCTCGGGGAGCACACCCTTGTTCAGCAGCTCTTCCCCGGGATACCCTTT       GACCTCAGGAACGGTTTACACGCCCCCGCCCCGCCTGCTGCCCAGGAATACTTTCTCCAGGAAGGcTT       TCAAGCTGAAGAAGCCCTCCAAATACTGCAGCTGGAAATGTGCTGCCCTCTCCGCCATTGCCGCGGCC       CTCCTCTTGGCTATTTTGC                                                 NOV7i, CG50426-02   SEQ ID NO: 130   390 aa   MW at 42705.6kD               Protein Sequence                     MDVKDRPHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRE           SDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGI       KSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSN       TSHQIMDTNPDEEFSPNSYLLPACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNR       NSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLT       SGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAIL                                             NOV7j, CG50426-03   SEQ ID NO: 131   4888 bp               DNA Sequence   ORF Start: ATG at 247   ORF Stop: TGA at 1840                       TACTCACTATAGGGCTCGAGCGGCCGCCCGGGCAGGTCCAGCATTAGATGAGTTGACAAAAATGCAGT               TTCAGCTCTGAAGGTCTGAAAGATTCTGCTGCAACTAAAGCTCTGAAGATTCTGCTACAACTATGACA           TCCATTTTCTCCCACTTCAGACAGGATGAATACAAGGTGGCAAAGTGACAAGTGCCAAAACTCAGGCC           TGACTTTCCTGAAAACATCAGCATTCTGCCATATCTGGAATA   ATG GATGTAAAGGACCGGCGACACCG       CTCTTTGACCAGAGGACGCTGTGGCAAAGAGTGTCGCTACACAAGCTCCTCTCTGGACAGTGAGGACT       GCCGGGTGCCCACACAGAAATCCTACAGCTCCAGTGAGACTCTGAAGGCCTATGACCATGACAGCAGG       ATGCACTATGGAAACCGAGTCACAGACCTCATCCACCGGGAGTCAGATGAGTTTCCTAGACAAGGAAC       CAACTTCACCCTTGCCGAACTGGGCATCTGTGAGCCCTCCCCACACCGAAGCGGCTACTGCTCCGACA       TGGGGATCCTTCACCAGGGCTACTCCCTTAGCACAGGGTCTGACGCCGACTCCGACACCGAGGGAGGG       ATGTCTCCAGAACACGCCATCAGACTGTGGGGCAGAGGGATAAAATCCAGGCGCAGTTCCGGCCTGTC       CAGTCGTGAAAACTCGGCCCTTACCCTGACTGACTCTGACAACGAAAACAAATCAGATGATGAGAACG       GTCGTCCCATTCCACCTACATCCTCGCCTAGTCTCCTCCCATCTGCTCAGCTGCCTAGCTCCCATAAT       CCTCCACCAGTTAGCTGCCAGATGCCATTGCTAGACAGCAACACCTCCCATCAAATCATGGACACCAA       CCCTGATGAGGAATTCTCCCCCAATTCATACCTGCTCAGAGCATGCTCAGGGCCCCAGCAAGCCTCCA       GCAGTGGCCCTCCGAACCACCACAGCCAGTCGACTCTGAGGCCCCCTCTCCCACCCCCTCACAACCAC       ACGCTGTCCCATCACCACTCGTCCGCCAACTCCCTCAACAGGAACTCACTGACCAATCGGCGGAGTCA       GATCCACGCCCCGGCCCCAGCGCCCAATGACCTGGCCACCACACCAGAGTCCGTTCAGCTTCAGGACA       GCTGGGTGCTAAACAGCAACGTGCCACTGGAGACCCGGCACTTCCTCTTCAAGACCTCCTCGGGGAGC       ACACCCTTGTTCAGCAGCTCTTCCCCGGGATACCCTTTGACCTCAGGAACGGTTTACACGCCCCCGCC       CCGCCTGCTGCCCAGGAATACTTTCTCCAGGAAGGCTTTCAAGCTGAAGAAGCCCTCCAAATACTGCA       GCTGGAAATGTGCTGCCCTCTCCGCCATTGCCGCGGCCCTCCTCTTGGCTATTTTGCTGGCGTATTTC       ATAGTGCCCTGGTCGTTGAAAAACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGTCGGCGGGTAAC       ACAAGAAGTCCCACCAGGGGTGTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCAGTTCTTAAAGT       TCAACATCTCCCTCGGGAAGGACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTCCACCATCTCAT       GCCCAGTATGACTTCATGGAACGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAGTCTCCCAGGGA       ACGCCGGAGCATACAGACCTTGGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGATGTGGGCCTGT       GGCATCTGGCCTTCTACAATGATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTGTTGTCCTAGAT       AGC TGA   GGTAGCCGGCTCTGGCCTCGGCTAGCCCAGAAAGGGGCTCCCACAGTGCAGCAGCGGGCTGA           AGGGCTCCTCAAGCGTGGCCAGAGTGGGCGCTGAGGCCGAGGAGGCACCGAGAGCGAGCGAGGGCTGC           AAGGTCTGCCAGCACGCTGTCACTTCTCACTATTTTGATTGGTATTGTGTCCGGAATTGGTGGGTTCT           TGGTCTCACTGACTTCAAGAATGAAGCCACGGACCCTCGCGTTACATCCAGCTTTTTAATTGCCTAAG           CGGTCTGGGGCTTGCTTCGTCATTTGGCTTTGCTGTGGAGCACTCCTGTAAAGCCAGCTGAATTGTAC           ATCGAAGATCCACCCTTTTGGTGGCAAAGTGACAAGTGCCAAAACTCAGGCCTGACTTTTCTGAAAAC           ATCAGCATTCTGCCATATCTGGAATAATGGATGTAAAGGACCGGCGACACCGCTCTTTGACCAGAGGA           CGCTGTGGCAAAGAGTGTCGCTACACAAGCTCCTCTCTGGACAGTGAGGACTGCCGGGTGCCCACACA           GAAATCCTACAGCTCCAGTGAGACTCTGAAGGCCTATGACCATGACAGCAGGATGCACTATGGAAACC           GAGTCACAGACCTCATCCACCGGGAGTCAGATGAGTTTCCTAGACAAGGAACCAACTTCACCCTTGCC           GAACTGGGCATCTGTGAGCCCTCCCCACACCGAAGCGGCTACTGCTCCGACATGGGGATCCTTCACCA           GGGCTACTCCCTTAGCACAGGGTCTGACGCCGACTCCGACACCGAGGGAGGGATGTCTCCAGAACACG           CCATCAGACTGTGGGGCAGAGGGATAAAATCCAGGCGCAGTTCCGGCCTGTCCAGTCGTGAAAACTCG           GCCCTTACCCTGACTGACTCTGACAACGAAAACAAATCAGATGATGAGAACGGTCGTCCCATTCCACC           TACATCCTCGCCTAGTCTCCTCCCATCTGCTCAGCTGCCTAGCTCCCATAATCCTCCACCAGTTAGCT           GCCAGATGCCATTGCTAGACAGCAACACCTCCCATCAAATCATGGACACCAACCCTGATGAGGAATTC           TCCCCCAATTCATACCTGCTCAGAGCATGCTCAGGGCCCCAGCAAGCCTCCAGCAGTGGCCCTCCGAA           CCACCACAGCCAGTCGACTCTGAGGCCCCCTCTCCCACCCCCTCACAACCACACGCTGTCCCATCACC           ACTCGTCCGCCAACTCCCTCAACAGGAACTCACTGACCAATCGGCGGAGTCAGATCCACGCCCCGGCC           CCAGCGCCCAATGACCTGGCCACCACACCAGAGTCCGTTCAGCTTCAGGACAGCTGGGTGCTAAACAG           CAACGTGCCACTGGAGACCCGGCACTTCCTCTTCAAGACCTCCTCGGGGAGCACACCCTTGTTCAGCA           GCTCTTCCCCGGGATACCCTTTGACCTCAGGAACGGTTTACACGCCCCCGCCCCGCCTGCTGCCCAGG           AATACTTTCTCCAGGAAGGCTTTCAAGCTGAAGAAGCCCTCCAAATACTGCAGCTGGAAATGTGCTGC           CCTCTCCGCCATTGCCGCGGCCCTCCTCTTGGCTATTTTGCGCTCCAAAGCGAGCTGGGACCGAAGAC           TCTAGGCTAAGTTATCTATGTAGATGGTGTCAGGGAGCGAAGCTACTGACCGAGCTGCTGTTACATCC           AGCTTTTTAATTGCCTAAGCGGTCTGGGGCTTGCTTCGTCATTTGGCTTTGCTGTGGAGCACTCCTGT           AAAGCCAGCTGAATTGTACATCGAAGATCCACCCTTTTGGTGGCAAAGTGACAAGTGCCAAAACTCAG           GCCTGACTTTTCTGAAAACATCAGCATTCTGCCATATCTGGAATAATGGATGTAAAGGACCGGCGACA           CCGCTCTTTGACCAGAGGACGCTGTGGCAAAGAGTGTCGCTACACAAGCTCCTCTCTGGACAGTGAGG           ACTGCCGGGTGCCCACACAGAAATCCTACAGCTCCAGTGAGACTCTGAAGGCCTATGACCATGACAGC           AGGATGCACTATGGAAACCGAGTCACAGACCTCATCCACCGGGAGTCAGATGAGTTTCCTAGACAAGG           AACCAACTTCACCCTTGCCGAACTGGGCATCTGTGAGCCCTCCCCACACCGAAGCGGCTACTGCTCCG           ACATGGGGATCCTTCACCAGGGCTACTCCCTTAGCACAGGGTCTGACGCCGACTCCGACACCGAGGGA           GGGATGTCTCCAGAACACGCCATCAGACTGTGGGGCAGAGGGATAAAATCCAGGCGCAGTTCCGGCCT           GTCCAGTCGTGAAAACTCGGCCCTTACCCTGACTGACTCTGACAACGAAAACAAATCAGATGATGAGA           ACGGTCGTCCCATTCCACCTACATCCTCGCCTAGTCTCCTCCCATCTGCTCAGCTGCCTAGCTCCCAT           AATCCTCCACCAGTTAGCTGCCAGATGCCATTGCTAGACAGCAACACCTCCCATCAAATCATGGACAC           CAACCCTGATGAGGAATTCTCCCCCAATTCATACCTGCTCAGAGCATGCTCAGGGCCCCAGCAAGCCT           CCAGCAGTGGCCCTCCGAACCACCACAGCCAGTCGACTCTGAGGCCCCCTCTCCCACCCCCTCACAAC           CACACGCTGTCCCATCACCACTCGTCCGCCAACTCCCTCAACAGGAACTCACTGACCAATCGGCGGAG           TCAGATCCACGCCCCGGCCCCAGCGCCCAATGACCTGGCCACCACACCAGAGTCCGTTCAGCTTCAGG           ACAGCTGGGTGCTAAACAGCAACGTGCCACTGGAGACCCGGCACTTCCTCTTCAAGACCTCCTCGGGG           AGCACACCCTTGTTCAGCAGCTCTTCCCCGGGATACCCTTTGACCTCAGGAACGGTTTACACGCCCCC           GCCCCGCCTGCTGCCCAGGAATACTTTCTCCAGGAAGGCTTTCAAGCTGAAGAAGCCCTCCAAATACT           GCAGCTGGAAATGTGCTGCCCTCTCCGCCATTGCCGCGGCCCTCCTCTTGGCTATTTTGC                                                   NOV7j, CG50426-03   SEQ ID NO: 132   531 aa   MW at 58938.0kD               Protein Sequence                     MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRE           SDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGTLHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGI       KSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSN       TSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNR       NSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLT       SGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKNSSIDSG       EAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEK       WSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDS                                             NOV7k, CG50426-04   SEQ ID NO: 133   1605 bp               DNA Sequence   ORF Start: ATG at 435   ORF Stop: at 1605                       AGCTGAGGTAGCCGGCTCTGGCCTCGGCTAGCCCAGAAAGGGGCTCCCACAGTGCAGCAGCGGGCTGA               AGGGCTCCTCAAGCGTGGCCAGAGTGGGCGCTGAGGCCGAGGAGGCACCGAGAGCGAGCGAGGGCTGC           AAGGTCTGCCAGCACGCTGTCACTTCTCACTATTTTGATTGGTATTGTGTCCGGAATTGGTGGGTTCT           TGGTCTCACTGACTTCAAGAATGAAGCCACGGACCCTCGCGTTACATCCAGCTTTTTAATTGCCTAAC           CGGTCTGGGGCTTGCTTCGTCATTTGGCTTTGCTGTGGAGCACTCCTGTAAAGCCAGCTGAATTGTAC           ATCGAAGATCCACCCTTTTGGTGGCAAAGTGACAAGTGCCAAAACTCAGGCCTGACTTTTCTGAAAAC           ATCAGCATTCTGCCATATCTGGAATA   ATG GATGTAAAGGACCGGCGACACCGCTCTTTGACCAGAGGA       CGCTGTGGCAAAGAGTGTCGCTACACAAGCTCCTCTCTGGACAGTGAGGACTGCCGGGTGCCCACACA       GAAATCCTACAGCTCCAGTGAGACTCTGAAGGCCTATGACCATGACAGCAGGATGCACTATGGAAACC       GAGTCACAGACCTCATCCACCGGGAGTCAGATGAGTTTCCTAGACAAGGAACCAACTTCACCCTTGCC       GAACTGGGCATCTGTGAGCCCTCCCCACACCGAAGCGGCTACTGCTCCGACATGGGGATCCTTCACCA       GGGCTACTCCCTTAGCACAGGGTCTGACGCCGACTCCGACACCGAGGGAGGGATGTCTCCAGAACACG       CCATCAGACTGTGGGGCAGAGGGATAAAATCCAGGCGCAGTTCCGGCCTGTCCAGTCGTGAAAACTCG       GCCCTTACCCTGACTGACTCTGACAACGAAAACAAATCAGATGATGAGAACGGTCGTCCCATTCCACC       TACATCCTCGCCTAGTCTCCTCCCATCTGCTCAGCTGCCTAGCTCCCATAATCCTCCACCAGTTAGCT       GCCAGATGCCATTGCTAGACAGCAACACCTCCCATCAAATCATGGACACCAACCCTGATGAGGAATTC       TCCCCCAATTCATACCTGCTCAGAGCATGCTCAGGGCCCCAGCAAGCCTCCAGCAGTGGCCCTCCGAA       CCACCACAGCCAGTCGACTCTGAGGCCCCCTCTCCCACCCCCTCACAACCACACGCTGTCCCATCACC       ACTCGTCCGCCAACTCCCTCAACAGGAACTCACTGACCAATCGGCGGAGTCAGATCCACGCCCCGGCC       CCAGCGCCCAATGACCTGGCCACCACACCAGAGTCCGTTCAGCTTCAGGACAGCTGGGTGCTAAACAG       CAACGTGCCACTGGAGACCCGGCACTTCCTCTTCAAGACCTCCTCGGGGAGCACACCCTTGTTCAGCA       GCTCTTCCCCGGGATACCCTTTGACCTCAGGAACGGTTTACACGCCCCCGCCCCGCCTGCTGCCCAGG       AATACTTTCTCCAGGAAGGCTTTCAAGCTGAAGAAGCCCTCCAAATACTGCAGCTGGAAATGTGCTGC       CCTCTCCGCCATTGCCGCGGCCCTCCTCTTGGCTATTTTGC                                                 NOV7k, CG50426-04   SEQ ID NO: 134   390 aa   MW at 42705.6kD               Protein Sequence                     MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRE           SDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGI       KSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSN       TSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNR       NSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLT       SGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAIL                                             NOV7l, CG50426-05   SEQ ID NO: 135   9668 bp               DNA Sequence   ORF Start: ATG at 122   ORF Stop: TAA at 8321                       GGGAGTTGGAACCAGCATTAGATGAGTTGACAAAAATGCAGTTTCAGGTGGCAAAGTGACAAGTGCCA               AAACTCAGGCCTGACTTTTCTGAAAACATCAGCATTCTGCCATATCTGGAATA   ATG GATGTAAAGGAC       CGGCGACACCGCTCTTTGACCAGAGGACGCTGTGGCAAAGAGTGTCGCTACACAAGCTCCTCTCTGGA       CAGTGAGGACTGCCGGGTGCCCACACAGAAATCCTACAGCTCCAGTGAGACTCTGAAGGCCTATGACC       ATGACAGCAGGATGCACTATGGAAACCGAGTCACAGACCTCATCCACCGGGAGTCAGATGAGTTTCCT       AGACAAGGAACCAACTTCACCCTTGCCGAACTGGGCATCTGTGAGCCCTCCCCACACCGAAGCGGCTA       CTGCTCCGACATGGGGATCCTTCACCAGGGCTACTCCCTTAGCACAGGGTCTGACGCCGACTCCGACA       CCGAGGGAGGGATGTCTCCAGAACACGCCATCAGACTGTGGGGCAGAGGGATAAAATCCAGGCGCAGT       TCCGGCCTGTCCAGTCGTGAAAACTCGGCCCTTACCCTGACTGACTCTGACAACGAAAACAAATCAGA       TGATGAGAACGGTCGTCCCATTCCACCTACATCCTCGCCTAGTCTCCTCCCATCTGCTCAGCTGCCTA       GCTCCCATAATCCTCCACCAGTTAGCTGCCAGATGCCATTGCTAGACAGCAACACCTCCCATCAAATC       ATGGACACCAACCCTGATGAGGAATTCTCCCCCAATTCATACCTGCTCAGAGCATGCTCAGGGCCCCA       GCAAGCCTCCAGCAGTGGCCCTCCGAACCACCACAGCCAGTCGACTCTGAGGCCCCCTCTCCCACCCC       CTCACAACCACACGCTGTCCCATCACCACTCGTCCGCCAACTCCCTCAACAGGAACTCACTGACCAAT       CGGCGGAGTCAGATCCACGCCCCGGCCCCAGCGCCCAATGACCTGGCCACCACACCAGAGTCCGTTCA       GCTTCAGGACAGCTGGGTGCTAAACAGCAACGTGCCACTGGAGACCCGGCACTTCCTCTTCAAGACCT       CCTCGGGGAGCACACCCTTGTTCAGCAGCTCTTCCCCGGGATACCCTTTGACCTCAGGAACGGTTTAC       ACGCCCCCGCCCCGCCTGCTGCCCAGGAATACTTTCTCCAGGAAGGCTTTCAAGCTGAAGAAGCCCTC       CAAATACTGCAGCTGGAAATGTGCTGCCCTCTCCGCCATTGCCGCGGCCCTCCTCTTGGCTATTTTGC       TGGCGTATTTCATAGTGCCCTGGTCGTTGAAAAACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGT       CGGCGGGTAACACAAGAAGTCCCACCAGGGGTGTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCA       GTTCTTAAAGTTCAACATCTCCCTCGGGAAGGACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTC       CACCATCTCATGCCCAGTATGACTTCATGGAACGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAG       TCTCCCAGGGAACGCCGGAGCATACAGACCTTGGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGA       TGTGGGCCTGTGGCATCTGGCCTTCTACAATGATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTG       TTGTCCTAGATTCAGTGCAGGACTGTCCACGTAACTGCCATGGGAATGGTGAATGTGTGTCCGGGGTG       TGTCACTGTTTCCCAGGATTTCTAGGAGCAGACTGTGCTAAAGCTGCCTGCCCTGTCCTGTGCAGTGG       GAATGGACAATATTCTAAAGGGACGTGCCAGTGCTACAGCGGCTGGAAAGGTGCAGAGTGCGACGTGC       CCATGAATCAGTGCATCGATCCTTCCTGCGGGGGCCACGGCTCCTGCATTGATGGGAACTGTGTCTGC       TCTGCTGGCTACAAAGGCGAGCACTGTGAGGAAGTTGATTGCTTGGATCCCACCTGCTCCAGCCACGG       AGTCTGTGTGAATGGAGAATGCCTGTGCAGCCCTGGCTGGGGTGGTCTGAACTGTGAGCTGGCGAGGG       TCCAGTGCCCAGACCAGTGCAGTGGGCATGGCACGTACCTGCCTGACACGGGCCTCTGCAGCTGCGAT       CCCAACTGGATGGGTCCCGACTGCTCTGTTGAAGTGTGCTCAGTAGACTGTGGCACTCACGGCGTCTG       CATCGGGGGAGCCTGCCGCTGTGAAGAGGGCTGGACAGGCGCAGCGTGTGACCAGCGCGTGTGCCACC       CCCGCTGCATTGAGCACGGGACCTGTAAAGATGGCAAATGTGAATGCCGAGAGGGCTGGAATGGTGAA       CACTGCACCATTGGTAGGCAAACGGCAGGCACCGAAACAGATGGCTGCCCTGACTTGTGCAACGGTAA       CGGGAGATGCACACTGGGTCAGAACAGCTGGCAGTGTGTCTGCCAGACCGGCTGGAGAGGGCCCGGAT       GCAACGTTGCCATGGAAACTTCCTGTGCTGATAACAAGGATAATGAGGGAGATGGCCTGGTGGATTGT       TTGGACCCTGACTGCTGCCTGCAGTCAGCCTGTCAGAACAGCCTGCTCTGCCGGGGGTCCCGGGACCC       ACTGGACATCATTCAGCAGGGCCAGACGGATTGGCCCGCAGTGAAGTCCTTCTATGACCGTATCAAGC       TCTTGGCAGGCAAGGATAGCACCCACATCATTCCTGGAGAGAACCCTTTCAACAGCAGCTTGGTTTCT       CTCATCCGAGGCCAAGTAGTAACTACAGATGGAACTCCCCTGGTCGGTGTGAACGTGTCTTTTGTCAA       GTACCCAAAATACGGCTACACCATCACCCGCCAGGATGGCACGTTCGACCTGATCGCAAATGGAGGTG       CTTCCTTGACTCTACACTTTGAGCGAGCCCCGTTCATGAGCCAGGAGCGCACTGTGTGGCTGCCGTGG       AACAGCTTTTACGCCATGGACACCCTGGTGATGAAGACCGAGGAGAACTCCATCCCCAGCTGTGACCT       CAGTGGCTTTGTCCGGCCTGATCCAATCATCATCTCCTCCCCACTGTCCACCTTCTTTAGTGCTGCCC       CTGGGCAGAATCCCATCGTGCCTGAGACCCAGGTTCTTCATGAAGAAATCGAGCTCCCTGGTTCCAAT       GTGAAACTTCGCTATCTGAGCTCTAGAACTGCAGGGTACAAGTCACTGCTGAAGATCACCATGACCCA       GTCCACAGTGCCCCTGAACCTCATTAGGGTTCACCTGATGGTGGCTGTCGAGGGGCATCTCTTCCAGA       AGTCATTCCAGGCTTCTCCCAACCTGGCCTCCACCTTCATCTGGGACAAGACAGATGCGTATGGCCAA       AGGGTGTATGGACTCTCAGATGCTGTTGTGTCTGTCGGGTTTGAATATGAGACCTGTCCCAGTCTAAT       TCTCTGGGAGAAAAGGACAGCCCTCCTTCAGGGATTCGAGCTGGACCCCTCCAACCTCGGTGGCTGGT       CCCTAGACAAACACCACATCCTCAATGTTAAAAGTGGAATCCTACACAAAGGCACTGGGGAAAACCAG       TTCCTGACCCAGCAGCCTGCCATCATCACCAGCATCATGGGCAATGGTCGCCGCCGGAGCATTTCCTG       TCCCAGCTGCAACGGCCTTGCTGAAGGCAACAAGCTGCTGGCCCCAGTGGCTCTGGCTGTTGGAATCG       ATGGGAGCCTCTATGTGGGTGACTTCAATTACATCCGACGCATCTTTCCCTCTCGAAATGTGACCAGC       ATCTTGGAGTTACGAAATAAAGAGTTTAAACATAGCAACAACCCAGCACACAAGTACTACTTGGCAGT       GGACCCCGTGTCCGGCTCGCTCTACGTGTCCGACACCAACAGCAGGAGAATCTACCGCGTCAAGTCTC       TGAGTGGAACCAAAGACCTGGCTGGGAATTCGGAAGTTGTGGCAGGGACGGGAGAGCAGTGTCTACCC       TTTGATGAAGCCCGCTGCGGGGATGGAGGGAAGGCCATAGATGCAACCCTGATGAGCCCGAGAGGTAT       TGCAGTAGACAAGAATGGGCTCATGTACTTTGTCGATGCCACCATGATCCGGAAGGTTGACCAGAATG       GAATCATCTCCACCCTGCTGGGCTCCAATGACCTCACTGCCGTCCGGCCGCTGAGCTGTGATTCCAGC       ATGGATGTAGCCCAGGTTCGTCTGGAGTGGCCAACAGACCTTGCTGTCAATCCCATGGATAACTCCTT       GTATGTTCTAGAGAACAATGTCATCCTTCGAATCACCGAGAACCACCAAGTCAGCATCATTGCGGGAC       GCCCCATGCACTGCCAAGTTCCTGGCATTGACTACTCACTCAGCAAACTAGCCATTCACTCTGCCCTG       GAGTCAGCCAGTGCCATTGCCATTTCTCACACTGGGGTCCTCTACATCACTGAGACAGATGAGAAGAA       GATTAACCGTCTACGCCAGGTAACAACCAACGGGGAGATCTGCCTTTTAGCTGGGGCAGCCTCGGACT       GCGACTGCAAAAACGATGTCAATTGCAACTGCTATTCAGGAGATGATGCCTACGCGACTGATGCCATC       TTGAATTCCCCATCATCCTTAGCTGTAGCTCCAGATGGTACCATTTACATTGCAGACCTTGGAAATAT       TCGGATCAGGGCGGTCAGCAAGAACAAGCCTGTTCTTAATGCCTTCAACCAGTATGAGGCTGCATCCC       CCGGAGAGCAGGAGTTATATGTTTTCAACGCTGATGGCATCCACCAATACACTGTGAGCCTGGTGACA       GGGGAGTACTTGTACAATTTCACATATAGTACTGACAATGATGTCACTGAATTGATTGACAATAATGG       GAATTCCCTGAAGATCCGTCGGGACAGCAGTGGCATGCCCCGTCACCTGCTCATGCCTGACAACCAGA       TCATCACCCTCACCGTGGGCACCAATGGAGGCCTCAAAGTCGTGTCCACACAGAACCTGGAGCTTGGT       CTCATGACCTATGATGGCAACACTGGGCTCCTGGCCACCAAGAGCGATGAAACAGGATGGACGACTTT       CTATGACTATGACCACGAAGGCCGCCTGACCAACGTGACGCGCCCCACGGGGGTGGTAACCAGTCTGC       ACCGGGAAATGGAGAAATCTATTACCATTGACATTGAGAACTCCAACCGTGATGATGACGTCACTGTC       ATCACCAACCTCTCTTCAGTAGAGGCCTCCTACACAGTGGTACAAGATCAAGTTCGGAACAGCTACCA       GCTCTGTAATAATGGTACCCTGAGGGTGATGTATGCTAATGGGATGGGTATCAGCTTCCACAGCGAGC       CCCATGTCCTAGCGGGCACCATCACCCCCACCATTGGACGCTGCAACATCTCCCTGCCTATGGAGAAT       GGCTTAAACTCCATTGAGTGGCGCCTAAGAAAGGAACAGATTAAAGGCAAAGTCACCATCTTTGGCAG       GAAGCTCCGGGTCCATGGAAGAAATCTCTTGTCCATTGACTATGATCGAAATATTCGGACTGAAAAGA       TCTATGATGACCACCGGAAGTTCACCCTGAGGATCATTTATGACCAGGTGGGCCGCCCCTTCCTCTGG       CTGCCCAGCAGCGGGCTGGCAGCTGTCAACGTGTCATACTTCTTCAATGGGCGCCTGGCTGGGCTTCA       GCGTGGGGCCATGAGCGAGAGGACAGACATCGACAAGCAAGGCCGCATCGTGTCCCGCATGTTCGCTG       ACGGGAAAGTGTGGAGCTACTCCTACCTTGACAAGTCCATGGTCCTCCTGCTTCAGAGCCAACGTCAG       TATATATTTGAGTATGACTCCTCTGACCGCCTCCTTGCCGTCACCATGCCCAGCGTGGCCCGGCACAG       CATGTCCACACACACCTCCATCGGCTACATCCGTAATATTTACAACCCGCCTGAAAGCAATGCTTCGG       TCATCTTTGACTACAGTGATGACGGCCGCATCCTGAAGACCTCCTTTTTGGGCACCGGACGCCAGGTG       TTCTACAAGTATGGGAAACTCTCCAAGTTATCAGAGATTGTCTACGACAGTACCGCCGTCACCTTCGG       GTATGACGAGACCACTGGTGTCTTGAAGATGGTCAACCTCCAAAGTGGGGGCTTCTCCTGCACCATCA       GGTACCGGAAGATTGGCCCCCTGGTGGACAAGCAGATCTACAGGTTCTCCGAGGAAGGCATGGTCAAT       GCCAGGTTTGACTACACCTATCATGACAACAGCTTCCGCATCGCAAGCATCAAGCCCGTCATAAGTGA       GACTCCCCTCCCCGTTGACCTCTACCGCTATGATGAGATTTCTGGCAAGGTGGAACACTTTGGTAAGT       TTGGAGTCATCTATTATGACATCAACCAGATCATCACCACTGCCGTGATGACCCTCAGCAAACACTTC       GACACCCATGGGCGGATCAAGGAGGTCCAGTATGAGATGTTCCGGTCCCTCATGTACTGGATGACGGT       GCAATATGACAGCATGGGCAGGGTGATCAAGAGGGAGCTAAAACTGGGGCCCTATGCCAATACCACGA       AGTACACCTATGACTACGATGGGGACGGGCAGCTCCAGAGCGTGGCCGTCAATGACCGCCCGACCTGG       CGCTACAGCTATGACCTTAATGGGAATCTCCACTTACTGAACCCAGGCAACAGTGTGCGCCTCATGCC       CTTGCGCTATGACCTCCGGGATCGGATAACCAGACTCGGGGATGTGCAGTACAAAATTGACGACGATG       GCTATCTGTGCCAGAGAGGGTCTGACATCTTCGAATACAATTCCAAGGGCCTCCTAACAAGAGCCTAC       AACAAGGCCAGCGGGTGGAGTGTCCAGTACCGCTATGATGGCGTAGGACGGCGGGCTTCCTACAAGAC       CAACCTGGGCCACCACCTGCAGTACTTCTACTCTGACCTCCACAACCCGACGCGCATCACCCATGTCT       ACAATCACTCCAACTCGGAGATTACCTCACTGTACTACGACCTCCAGGGCCACCTCTTTGCCATGGAG       AGCAGCAGTGGGGAGGAGTACTATGTTGCCTCTGATAACACAGGGACTCCTCTGGCTGTGTTCAGCAT       CAACGGCCTCATGATCAAACAGCTGCAGTACACGGCCTATGGGGAGATTTATTATGACTCCAACCCCG       ACTTCCAGATGGTCATTGGCTTCCATGGGGGACTCTATGACCCCCTGACCAAGCTGGTCCACTTCACT       CAGCGTGATTATGATGTGCTGGCAGGACGATGGACCTCCCCAGACTATACCATGTGGAAAAACGTGGG       CAAGGAGCCGGCCCCCTTTAACCTGTATATGTTCAAGAGCAACAATCCTCTCAGCAGTGAGCTAGATT       TGAAGAACTACGTGACAGATGTGAAAAGCTGGCTTGTGATGTTTGGATTTCAGCTTAGCAACATCATT       CCTGGCTTCCCGAGAGCCAAAATGTATTTCGTGCCTCCTCCCTATGAATTGTCAGAGAGTCAAGCAAG       TGAGAATGGACAGCTCATTACAGGTGTCCAACAGACAACAGAGAGACATAACCAGGCCTTCATGGCTC       TGGAAGGACAGGTCATTACTAAAAAGCTCCACGCCAGCATCCGAGAGAAAGCAGGTCACTGGTTTGCC       ACCACCACGCCCATCATTGGCAAAGGCATCATGTTTGCCATCAAAGAAGGGCGGGTGACCACGGGCGT       GTCCAGCATCGCCAGCGAAGATAGCCGCAAGGTGGCATCTGTGCTGAACAACGCCTACTACCTGGACA       AGATGCACTACAGCATCGAGGGCAAGGACACCCACTACTTTGTGAAGATTGGCTCAGCCGATGGCGAC       CTGGTCACACTAGGCACCACCATCGGCCGCAAGGTGCTAGAGAGCGGGGTGAACGTGACCGTGTCCCA       GCCCACGCTGCTGGTCAACGGCAGGACTCGAAGGTTCACGAACATTGAGTTCCAGTACTCCACGCTGC       TGCTCAGCATCCGCTATGGCCTCACCCCCGACACCCTGGACGAAGAGAAGGCCCGCGTCCTGGACCAG       GCGAGACAGAGGGCCCTGGGCACGGCCTGGGCCAAGGAGCAGCAGAAAGCCAGGGACGGGAGAGAGGG       GAGCCGCCTGTGGACTGAGGGCGAGAAGCAGCAGCTTCTGAGCACCGGGCGCGTGCAAGGGTACGAGG       GATATTACGTGCTTCCCGTGGAGCAATACCCAGAGCTTGCAGACAGTAGCAGCAACATCCAGTTTTTA       AGACAGAATGAGATGGGAAAGAGG TAA   CAAAATAATCTGCTGCCATTCCTTGTCTGAATGGCTCAGCA           GGAGTAACTGTTATCTCCTCTCCTAAGGAGATGAAGACCTAACAGGGGCACTGCGGCTGCGCTGCTTT           AGGAGACCAAGTGGCAAGAAAGCTCACATTTTTTGAGTTCAAATGCTACTGTCCAAGCGAGAAGTCCC           TCATCCTGAAGTAGACTAAAGCCCGGCTGAAAATTCCGAGGAAAACAAAACAAACGAATGAATGAACA           GACACACACAATGTTCCAAGTTCCCCTAAAATATGACCCACTTGTTCTGGGTCTACGCAGAAAAGAGA           CGCAAAGTGTCCAAAAGGAACAAAAGAACAAAAACGAATAAGCAAAGAAGAAAACAAACAAAAACAAA           ACAAAACAAACACACGGACCGATAAACAAAGAAGCGAAGATAAGAAAGAAGGCCTCATATCCAATTAC           CTCACTCATTCACATGTGAGCGACACGCAGACATCCGCGAGGGCCAGCGTCACCAGACCAGCTGCGGG           ACAAACCACTCAGACTGCTTGTAGGACAAATACTTCTGACATTTTCGTTTAAGCAAATACAGGTGCAT           TTAAAACACGACTTTGGGGGTGATTTGTGTGTAGCGCCTGGGGAGGGGGGATAAAAGAGGAGGAGTGA           GCACTGGAAATACTTTTTAAAGAAAAAAAAACATGAGGGAATAAAAGAAATTCCTATCAAAAATCAAA           GTGAAATAATACCATCCAGCACTTAACTCTCAGGTCCCAACTAAGTCTGGCCTGAGCTAATTTATTTG           AGCGCAGAGTGTAAAATTTAATTCAAAATGGTGGCTATAATCACTACAGATAAATTTCATACTCTTTT           GTCTTTGGAGATTCCATTGTGGACAGTAATACGCAGTTACAGGGTGTAGTCTGTTTAGATTCCGTAGT           TCGTGGGTATCAGTTTCGGTAGAGGTGCAGCATCGTGACACTTTTGCTAACAGGTACCACTTCTGATC           ACCCTGTACATACATGAGCCGAAAGGCACAATCACTGTTTCAGATTTAAAATTATTAGTGTGTTTGTT           TGGTCCAGAAACTGAGACAATCACATGACAGTCACCACGAGGAGAGAAAATTTAAAAAATAAAAATAA           AAACAAAAAAAATTTTAAAAATTAAAAAAACAAAAATAAAGTCTAATAAGAACTTTGGTACAGGAACT           TTTTTGTAATATACATGTATGAATTGTTCATCGAGTTTTTATATTAATTTTAATTTGCTGCTAAGCAA           AGACTAGGGACAGGCAAAGATAATTTATGGCAAAGTGTTTAAATTGTTTATACATAAATAAAGTCTCT           AAAACTCCTGTG                                                   NOV7l, CG50426-05   SEQ ID NO: 136   2733 aa   MW at 303423.3kD               Protein Sequence                     MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRE           SDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGI       KSPRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSN       TSHQIMDTNPDEEFSPNSYLLPACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNR       NSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLT       SGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKNSSIDSG       EAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEK       WSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGE       CVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCID       GNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTG       LCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECRE       GWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGD       GLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFN       SSLVSLIRGQVVITDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERT       VWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPTVPETQVLHEEIE       LPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLASTFIWDKT       DAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILHKG       TGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFNYIRRIFPS       RNVTSILELRNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTG       EQCLPFDEARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPL       SCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLA       IHSALESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSGDDAY       ATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYT       VSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQ       NLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRD       DDVTVITNLSSVEASYTVVQDQVFNSYQLCNNGTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNIS       LPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVG       RPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLL       QSQRQYIFEYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLG       TGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSE       EGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMT       LSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVN       DRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGL       LTRAYNKASGWSVQYRYDGVGRRASYKTNLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGH       LFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTK       LVHFTQRDYDVLAGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQ       LSNIIPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASIREKA       GHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKDTHYFVKIG       SADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYSTLLLSIRYGLTPDTLDEEKA       RVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSS       NIQFLRQNEMGKR                                             NOV7m, CG50426-06   SEQ ID NO: 137   1920 bp               DNA Sequence   ORF Start: at 180   ORF Stop: at 1920                       CCAGCATTAGATGAGTTGACAAAAATGCAGTTTCAGCTCTGAAGGTCTGAAAGATTCTGCTGCAACTA               AAGCTCTGAAGATTCTGCTACAACTATGACATCCATTTTCTCCCACTTCAGACAGGATGAATACAAGC           TGGCAAAGTGACAAGTGCCAAAACTCAGGCCTGACTTTCCTG AAAACATCAGCATTCTGCCATATCTG       GAATAATGGATGTAAAGGACCGGCGACACCGCTCTTTGACCAGAGGACGCTGTGGCAAAGAGTGTCGC       TACACAAGCTCCTCTCTGGACAGTGAGGACTGCCGGGTGCCCACACAGAAATCCTACAGCTCCAGTGA       GACTCTGAAGGCCTATGACCATGACAGCAGGATGCACTATGGAAACCGAGTCACAGACCTCATCCACC       GGGAGTCAGATGAGTTTCCTAGACAAGGAACCAACTTCACCCTTGCCGAACTGGGCATCTGTGAGCCC       TCCCCACACCGAAGCGGCTACTGCTCCGACATGGGGATCCTTCACCAGGGCTACTCCCTTAGCACAGG       GTCTGACGCCGACTCCGACACCGAGGGAGGGATGTCTCCAGAACACGCCATCAGACTGTGGGGCAGAG       GGATAAAATCCAGGCGCAGTTCCGGCCTGTCCAGTCGTGAAAACTCGGCCCTTACCCTGACTGACTCT       GACAACGAAAACAAATCAGATGATGAGAACGGTCGTCCCATTCCACCTACATCCTCGCCTAGTCTCCT       CCCATCTGCTCAGCTGCCTAGCTCCCATAATCCTCCACCAGTTAGCTGCCAGATGCCATTGCTAGACA       GCAACACCTCCCATCAAATCATGGACACCAACCCTGATGAGGAATTCTCCCCCAATTCATACCTGCTC       AGAGCATGCTCAGGGCCCCAGCAAGCCTCCAGCAGTGGCCCTCCGAACCACCACAGCCAGTCGACTCT       GAGGCCCCCTCTCCCACCCCCTCACAACCACACGCTGTCCCATCACCACTCGTCCGCCAACTCCCTCA       ACAGGAACTCACTGACCAATCGGCGGAGTCAGATCCACGCCCCGGCCCCAGCGCCCAATGACCTGGCC       ACCACACCAGAGTCCGTTCAGCTTCAGGACAGCTGGGTGCTAAACAGCAACGTGCCACTGGAGACCCG       GCACTTCCTCTTCAAGACCTCCTCGGGGAGCACACCCTTGTTCAGCAGCTCTTCCCCGGGATACCCTT       TGACCTCAGGAACGGTTTACACGCCCCCGCCCCGCCTGCTGCCCAGGAATACTTTCTCCAGGAAGGCT       TTCAAGCTGAAGAAGCCCTCCAAATACTGCAGCTGGAAATGTGCTGCCCTCTCCGCCATTGCCGCGGC       CCTCCTCTTGGCTATTTTGCTGGCGTATTTCATAGTGCCCTGGTCGTTGAAAAACAGCAGCATAGACA       GTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGGGGTGTTTTGGAGGTCACAA       ATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGAAGGACGCTCTCTTTGGTGT       TTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTATGACTTCATGGAACGTCTGGACGGGAAGG       AGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGACCTTGGTTCAGAATGAAGCC       GTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACAATGATGGAAAAGACAAAGA       GATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCAGGACTGTCCACGTAACTGCCATGGGAATG       GTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGCAGACTGTGCTAAAGGTATG       TGCCGCCACTTCCCTG                                                 NOV7m, CG50426-06   SEQ ID NO: 138   580 aa   MW at 64132.9kD               Protein Sequence                     KHQHSAISGIMDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYG           NRVTDLIHRESDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPE       HAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPV       SCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSH       HHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLF       SSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPW       SLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYD       FMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQD       CPRNCHGNGECVSGVCHCFPGFLGADCAKGMCRHFP                                             NOV7n, CG50426-07   SEQ ID NO: 139   1447 bp               DNA Sequence   ORF Start: at 247   ORF Stop: at 1447                       GCTCCAAAGCGAGCTGGGACCGAAGACTCTAGGCTAAGTTATCTATGTAGATGGTGTCAGGGAGCGAA               GCTACTGACCGAGCTGCTGTTACATCCAGCTTTTTAATTGCCTAAGCGGTCTGGGGCTTGCTTCGTCA           TTTGGCTTTGCTGTGGAGCACTCCTGTAAAGCCAGCTGAATTGTACATCGAAGATCCACCCTTTTGGT           GGCAAAGTGACAAGTGCCAAAACTCAGGCCTGACTTTTCTGA AAACATCAGCATTCTGCCATATCTGG       AATAATGGATGTAAAGGACCGGCGACACCGCTCTTTGACCAGAGGACGCTGTGGCAAAQAGTGTCGCT       ACACAAGCTCCTCTCTGGACAGTGAGGACTGCCGGGTGCCCACACAGAAATCCTACAGCTCCAGTGAG       ACTCTGAAGGCCTATGACCATGACAGCAGGATGCACTATGGAAACCGAGTCACAGACCTCATCCACCG       GGAGTCAGATGAGTTTCCTAGACAAGGAACCAACTTCACCCTTGCCGAACTGGGCATCTGTGAGCCCT       CCCCACACCGAAGCGGCTACTGCTCCGACATGGGGATCCTTCACCAGGGCTACTCCCTTAGCACAGGG       TCTGACGCCGACTCCGACACCGAGGGAGGGATGTCTCCAGAACACGCCATCAGACTGTGGGGCAGAGG       GATAAAATCCAGGCGCAGTTCCGGCCTGTCCAGTCGTGAAAACTCGGCCCTTACCCTGACTGACTCTG       ACAACGAAAACAAATCAGATGATGAGAACGGTCGTCCCATTCCACCTACATCCTCGCCTAGTCTCCTC       CCATCTGCTCAGCTGCCTAGCTCCCATAATCCTCCACCAGTTAGCTGCCAGATGCCATTGCTAGACAG       CAACACCTCCCATCAAATCATGGACACCAACCCTGATGAGGAATTCTCCCCCAATTCATACCTGCTCA       GAGCATGCTCAGGGCCCCAGCAAGCCTCCAGCAGTGGCCCTCCGAACCACCACAGCCAGTCGACTCTG       AGGCCCCCTCTCCCACCCCCTCACAACCACACGCTGTCCCATCACCACTCGTCCGCCAACTCCCTCAA       CAGGAACTCACTGACCAATCGGCGGAGTCAGATCCACGCCCCGGCCCCAGCGCCCAATGACCTGGCCA       CCACACCAGAGTCCGTTCAGCTTCAGGACAGCTGGGTGCTAAACAGCAACGTGCCACTGGAGACCCGG       CACTTCCTCTTCAAGACCTCCTCGGGGAGCACACCCTTGTTCAGCAGCTCTTCCCCGGGATACCCTTT       GACCTCAGGAACGGTTTACACGCCCCCGCCCCGCCTGCTGCCCAGGAATACTTTCTCCAGGAAGGCTT       TCAAGCTGAAGAAGCCCTCCAAATACTGCAGCTGGAAATGTGCTGCCCTCTCCGCCATTGCCGCGGCC       CTCCTCTTGGCTATTTTGC                                                 NOV7n, CG50426-07   SEQ ID NO: 140   400 aa   MW at 43764.8kD               Protein Sequence                     KHQHSAISGIMDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRNHYG           NRVTDLIHRESDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPE       HAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPV       SCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLEACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSH       HHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLF       SSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAIL                                             NOV7o, CG50426-08   SEQ ID NO: 141   9823 bp               DNA Sequence   ORF Start: ATG at 277   ORF Stop: TAA at 8476                       GCTCCAAAGCGAGCTGGGACCGAAGACTCTAGGCTAAGTTATCTATGTAGATGGTGTCAGGGAGCGAA               GCTACTGACCGAGCTGCTGTTACATCCAGCTTTTTAATTGCCTAAGCGGTCTGGGGCTTGCTTCGTCA           TTTGGCTTTGCTGTGGAGCACTCCTGTAAAGCCAGCTGAATTGTACATCGAAGATCCACCCTTTTGGT           GGCAAAGTGACAAGTGCCAAAACTCAGGCCTGACTTTTCTGAAAACATCAGCATTCTGCCATATCTGG           AATA   ATG GATGTAAAGGACCGGCGACACCGCTCTTTGACCAGAGGACGCTGTGGCAAAGAGTGTCGCT       ACACAAGCTCCTCTCTGGACAGTGAGGACTGCCGGGTGCCCACACAGAAATCCTACAGCTCCAGTGAG       ACTCTGAAGGCCTATGACCATGACAGCAGGATGCACTATGGAAACCGAGTCACAGACCTCATCCACCG       GGAGTCAGATGAGTTTCCTAGACAAGGAACCAACTTCACCCTTGCCGAACTGGGCATCTGTGAGCCCT       CCCCACACCGAAGCGGCTACTGCTCCGACATGGGGATCCTTCACCAGGGCTACTCCCTTAGCACAGGG       TCTGACGCCGACTCCGACACCGAGGGAGGGATGTCTCCAGAACACGCCATCAGACTGTGGGGCAGAGG       GATAAAATCCAGGCGCAGTTCCGGCCTGTCCAGTCGTGAAAACTCGGCCCTTACCCTGACTGACTCTG       ACAACGAAAACAAATCAGATGATGAGAACGGTCGTCCCATTCCACCTACATCCTCGCCTAGTCTCCTC       CCATCTGCTCAGCTGCCTAGCTCCCATAATCCTCCACCAGTTAGCTGCCAGATGCCATTGCTAGACAG       CAACACCTCCCATCAAATCATGGACACCAACCCTGATGAGGAATTCTCCCCCAATTCATACCTGCTCA       GAGCATGCTCAGGGCCCCAGCAAGCCTCCAGCAGTGGCCCTCCGAACCACCACAGCCAGTCGACTCTG       AGGCCCCCTCTCCCACCCCCTCACAACCACACGCTGTCCCATCACCACTCGTCCGCCAACTCCCTCAA       CAGGAACTCACTGACCAATCGGCGGAGTCAGATCCACGCCCCGGCCCCAGCGCCCAATGACCTGGCCA       CCACACCAGAGTCCGTTCAGCTTCAGGACAGCTGGGTGCTAAACAGCAACGTGCCACTGGAGACCCGG       CACTTCCTCTTCAAGACCTCCTCGGGGAGCACACCCTTGTTCAGCAGCTCTTCCCCGGGATACCCTTT       GACCTCAGGAACGGTTTACACGCCCCCGCCCCGCCTGCTGCCCAGGAATACTTTCTCCAGGAAGGCTT       TCAAGCTGAAGAAGCCCTCCAAATACTGCAGCTGGAAATGTGCTGCCCTCTCCGCCATTGCCGCGGCC       CTCCTCTTGGCTATTTTGCTGGCGTATTTCATAGTGCCCTGGTCGTTGAAAAACAGCAGCATAGACAG       TGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGGGGTGTTTTGGAGGTCACAAA       TTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGAAGGACGCTCTCTTTGGTGTT       TACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTATGACTTCATGGAACGTCTGGACGGGAAGGA       GAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGACCTTGGTTCAGAATGAAGCCG       TGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACAATGATGGAAAAGACAAAGAG       ATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCAGGACTGTCCACGTAACTGCCATGGGAATGG       TGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGCAGACTGTGCTAAAGCTGCCT       GCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAAGGGACGTGCCAGTGCTACAGCGGCTGGAAA       GGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGATCCTTCCTGCGGGGGCCACGGCTCCTGCAT       TGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCGAGCACTGTGAGGAAGTTGATTGCTTGGATC       CCACCTGCTCCAGCCACGGAGTCTGTGTGAATGGAGAATGCCTGTGCAGCCCTGGCTGGGGTGGTCTG       AACTGTGAGCTGGCGAGGGTCCAGTGCCCAGACCAGTGCAGTGGGCATGGCACGTACCTGCCTGACAC       GGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCGACTGCTCTGTTGAAGTGTGCTCAGTAGACT       GTGGCACTCACGGCGTCTGCATCGGGGGAGCCTGCCGCTGTGAAGAGGGCTGGACAGGCGCAGCGTGT       GACCAGCGCGTGTGCCACCCCCGCTGCATTGAGCACGGGACCTGTAAAGATGGCAAATGTGAATGCCG       AGAGGGCTGGAATGGTGAACACTGCACCATTGGTAGGCAAACGGCAGGCACCGAAACAGATGGCTGCC       CTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGTCAGAACAGCTGGCAGTGTGTCTGCCAGACC       GGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAACTTCCTGTGCTGATAACAAGGATAATGAGGG       AGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCCTGCAGTCAGCCTGTCAGAACAGCCTGCTCT       GCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAGGGCCAGACGGATTGGCCCGCAGTGAAGTCC       TTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAGCACCCACATCATTCCTGGAGAGAACCCTTT       CAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAGTAACTACAGATGGAACTCCCCTGGTCGGTG       TGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTACACCATCACCCGCCAGGATGGCACGTTCGAC       CTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTTTGAGCGAGCCCCGTTCATGAGCCAGGAGCG       CACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGGACACCCTGGTGATGAAGACCGAGGAGAACT       CCATCCCCAGCTGTGACCTCAGTGGCTTTGTCCGGCCTGATCCAATCATCATCTCCTCCCCACTGTCC       ACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGTGCCTGAGACCCAGGTTCTTCATGAAGAAAT       CGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGAGCTCTAGAACTGCAGGGTACAAGTCACTGC       TGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAACCTCATTAGGGTTCACCTGATGGTGGCTGTC       GAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCCCAACCTGGCCTCCACCTTCATCTGGGACAA       GACAGATGCGTATGGCCAAAGGGTGTATGGACTCTCAGATGCTGTTGTGTCTGTCGGGTTTGAATATG       AGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACAGCCCTCCTTCAGGGATTCGAGCTGGACCCC       TCCAACCTCGGTGGCTGGTCCCTAGACAAACACCACATCCTCAATGTTAAAAGTGGAATCCTACACAA       AGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTGCCATCATCACCAGCATCATGGGCAATGGTC       GCCGCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTTGCTGAAGGCAACAAGCTGCTGGCCCCAGTG       GCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGGTGACTTCAATTACATCCGACGCATCTTTCC       CTCTCGAAATGTGACCAGCATCTTGGAGTTACGAAATAAAGAGTTTAAACATAGCAACAACCCAGCAC       ACAAGTACTACTTGGCAGTGGACCCCGTGTCCGGCTCGCTCTACGTGTCCGACACCAACAGCAGGAGA       ATCTACCGCGTCAAGTCTCTGAGTGGAACCAAAGACCTGGCTGGGAATTCGGAAGTTGTGGCAGGGAC       GGGAGAGCAGTGTCTACCCTTTGATGAAGCCCGCTGCGGGGATGGAGGGAAGGCCATAGATGCAACCC       TGATGAGCCCGAGAGGTATTGCAGTAGACAAGAATGGGCTCATGTACTTTGTCGATGCCACCATGATC       CGGAAGGTTGACCAGAATGGAATCATCTCCACCCTGCTGGGCTCCAATGACCTCACTGCCGTCCGGCC       GCTGAGCTGTGATTCCAGCATGGATGTAGCCCAGGTTCGTCTGGAGTGGCCAACAGACCTTGCTGTCA       ATCCCATGGATAACTCCTTGTATGTTCTAGAGAACAATGTCATCCTTCGAATCACCGAGAACCACCAA       GTCAGCATCATTGCGGGACGCCCCATGCACTGCCAAGTTCCTGGCATTGACTACTCACTCAGCAAACT       AGCCATTCACTCTGCCCTGGAGTCAGCCAGTGCCATTGCCATTTCTCACACTGGGGTCCTCTACATCA       CTGAGACAGATGAGAAGAAGATTAACCGTCTACGCCAGGTAACAACCAACGGGGAGATCTGCCTTTTA       GCTGGGGCAGCCTCGGACTGCGACTGCAAAAACGATGTCAATTGCAACTGCTATTCAGGAGATGATGC       CTACGCGACTGATGCCATCTTGAATTCCCCATCATCCTTAGCTGTAGCTCCAGATGGTACCATTTACA       TTGCAGACCTTGGAAATATTCGGATCAGGGCGGTCAGCAAGAACAAGCCTGTTCTTAATGCCTTCAAC       CAGTATGAGGCTGCATCCCCCGGAGAGCAGGAGTTATATGTTTTCAACGCTGATGGCATCCACCAATA       CACTGTGAGCCTGGTGACAGGGGAGTACTTGTACAATTTCACATATAGTACTGACAATGATGTCACTG       AATTGATTGACAATAATGGGAATTCCCTGAAGATCCGTCGGGACAGCAGTGGCATGCCCCGTCACCTG       CTCATGCCTGACAACCAGATCATCACCCTCACCGTGGGCACCAATGGAGGCCTCAAAGTCGTGTCCAC       ACAGAACCTGGAGCTTGGTCTCATGACCTATGATGGCAACACTGGGCTCCTGGCCACCAAGAGCGATG       AAACAGGATGGACGACTTTCTATGACTATGACCACGAAGGCCGCCTGACCAACGTGACGCGCCCCACG       GGGGTGGTAACCAGTCTGCACCGGGAAATGGAGAAATCTATTACCATTGACATTGAGAACTCCAACCG       TGATGATGACGTCACTGTCATCACCAACCTCTCTTCAGTAGAGGCCTCCTACACAGTGGTACAAGATC       AAGTTCGGAACAGCTACCAGCTCTGTAATAATGGTACCCTGAGGGTGATGTATGCTAATGGGATGGGT       ATCAGCTTCCACAGCGAGCCCCATGTCCTAGCGGGCACCATCACCCCCACCATTGGACGCTGCAACAT       CTCCCTGCCTATGGAGAATGGCTTAAACTCCATTGAGTGGCGCCTAAGAAAGGAACAGATTAAAGGCA       AAGTCACCATCTTTGGCAGGAAGCTCCGGGTCCATGGAAGAAATCTCTTGTCCATTGACTATGATCGA       AATATTCGGACTGAAAAGATCTATGATGACCACCGGAAGTTCACCCTGAGGATCATTTATGACCAGGT       GGGCCGCCCCTTCCTCTGGCTGCCCAGCAGCGGGCTGGCAGCTGTCAACGTGTCATACTTCTTCAATG       GGCGCCTGGCTGGGCTTCAGCGTGGGGCCATGAGCGAGAGGACAGACATCGACAAGCAAGGCCGCATC       GTGTCCCGCATGTTCGCTGACGGGAAAGTGTGGAGCTACTCCTACCTTGACAAGTCCATGGTCCTCCT       GCTTCAGAGCCAACGTCAGTATATATTTGAGTATGACTCCTCTGACCGCCTCCTTGCCGTCACCATGC       CCAGCGTGGCCCGGCACAGCATGTCCACACACACCTCCATCGGCTACATCCGTAATATTTACAACCCG       CCTGAAAGCAATGCTTCGGTCATCTTTGACTACAGTGATGACGGCCGCATCCTGAAGACCTCCTTTTT       GGGCACCGGACGCCAGGTGTTCTACAAGTATGGGAAACTCTCCAAGTTATCAGAGATTGTCTACGACA       GTACCGCCGTCACCTTCGGGTATGACGAGACCACTGGTGTCTTGAAGATGGTCAACCTCCAAAGTGGG       GGCTTCTCCTGCACCATCAGGTACCGGAAGATTGGCCCCCTGGTGGACAAGCAGATCTACAGGTTCTC       CGAGGAAGGCATGGTCAATGCCAGGTTTGACTACACCTATCATGACAACAGCTTCCGCATCGCAAGCA       TCAAGCCCGTCATAAGTGAGACTCCCCTCCCCGTTGACCTCTACCGCTATGATGAGATTTCTGGCAAG       GTGGAACACTTTGGTAAGTTTGGAGTCATCTATTATGACATCAACCAGATCATCACCACTGCCGTGAT       GACCCTCAGCAAACACTTCGACACCCATGGGCGGATCAAGGAGGTCCAGTATGAGATGTTCCGGTCCC       TCATGTACTGGATGACGGTGCAATATGACAGCATGGGCAGGGTGATCAAGAGGGAGCTAAAACTGGGG       CCCTATGCCAATACCACGAAGTACACCTATGACTACGATGGGGACGGGCAGCTCCAGAGCGTGGCCGT       CAATGACCGCCCGACCTGGCGCTACAGCTATGACCTTAATGGGAATCTCCACTTACTGAACCCAGGCA       ACAGTGTGCGCCTCATGCCCTTGCGCTATGACCTCCGGGATCGGATAACCAGACTCGGGGATGTGCAG       TACAAAATTGACGACGATGGCTATCTGTGCCAGAGAGGGTCTGACATCTTCGAATACAATTCCAAGGG       CCTCCTAACAAGAGCCTACAACAAGGCCAGCGGGTGGAGTGTCCAGTACCGCTATGATGGCGTAGGAC       GGCGGGCTTCCTACAAGACCAACCTGGGCCACCACCTGCAGTACTTCTACTCTGACCTCCACAACCCG       ACGCGCATCACCCATGTCTACAATCACTCCAACTCGGAGATTACCTCACTGTACTACGACCTCCAGGG       CCACCTCTTTGCCATGGAGAGCAGCAGTGGGGAGGAGTACTATGTTGCCTCTGATAACACAGGGACTC       CTCTGGCTGTGTTCAGCATCAACGGCCTCATGATCAAACAGCTGCAGTACACGGCCTATGGGGAGATT       TATTATGACTCCAACCCCGACTTCCAGATGGTCATTGGCTTCCATGGGGGACTCTATGACCCCCTGAC       CAAGCTGGTCCACTTCACTCAGCGTGATTATGATGTGCTGGCAGGACGATGGACCTCCCCAGACTATA       CCATGTGGAAAAACGTGGGCAAGGAGCCGGCCCCCTTTAACCTGTATATGTTCAAGAGCAACAATCCT       CTCAGCAGTGAGCTAGATTTGAAGAACTACGTGACAGATGTGAAAAGCTGGCTTGTGATGTTTGGATT       TCAGCTTAGCAACATCATTCCTGGCTTCCCGAGAGCCAAAATGTATTTCGTGCCTCCTCCCTATGAAT       TGTCAGAGAGTCAAGCAAGTGAGAATGGACAGCTCATTACAGGTGTCCAACAGACAACAGAGAGACAT       AACCAGGCCTTCATGGCTCTGGAAGGACAGGTCATTACTAAAAAGCTCCACGCCAGCATCCGAGAGAA       AGCAGGTCACTGGTTTGCCACCACCACGCCCATCATTGGCAAAGGCATCATGTTTGCCATCAAAGAAG       GGCGGGTGACCACGGGCGTGTCCAGCATCGCCAGCGAAGATAGCCGCAAGGTGGCATCTGTGCTGAAC       AACGCCTACTACCTGGACAAGATGCACTACAGCATCGAGGGCAAGGACACCCACTACTTTGTGAAGAT       TGGCTCAGCCGATGGCGACCTGGTCACACTAGGCACCACCATCGGCCGCAAGGTGCTAGAGAGCGGGG       TGAACGTGACCGTGTCCCAGCCCACGCTGCTGGTCAACGGCAGGACTCGAAGGTTCACGAACATTGAG       TTCCAGTACTCCACGCTGCTGCTCAGCATCCGCTATGGCCTCACCCCCGACACCCTGGACGAAGAGAA       GGCCCGCGTCCTGGACCAGGCGAGACAGAGGGCCCTGGGCACGGCCTGGGCCAAGGAGCAGCAGAAAG       CCAGGGACGGGAGAGAGGGGAGCCGCCTGTGGACTGAGGGCGAGAAGCAGCAGCTTCTGAGCACCGGG       CGCGTGCAAGGGTACGAGGGATATTACGTGCTTCCCGTGGAGCAATACCCAGAGCTTGCAGACAGTAG       CAGCAACATCCAGTTTTTAAGACAGAATGAGATGGGAAAGAGG TAA   CAAAATAATCTGCTGCCATTCC           TTGTCTGAATGGCTCAGCAGGAGTAACTGTTATCTCCTCTCCTAAGGAGATGAAGACCTAACAGGGGC           ACTGCGGCTGGGCTGCTTTAGGAGACCAAGTGGCAAGAAAGCTCACATTTTTTGAGTTCAAATGCTAC           TGTCCAAGCGAGAAGTCCCTCATCCTGAAGTAGACTAAAGCCCGGCTGAAAATTCCGAGGAAAACAAA           ACAAACGAATGAATGAACAGACACACACAATGTTCCAAGTTCCCCTAAAATATGACCCACTTGTTCTG           GGTCTACGCAGAAAAGAGACGCAAAGTGTCCAAAAGGAACAAAAGAACAAAAACGAATAAGCAAAGAA           GAAAACAAACAAAAACAAAACAAAACAAACACACGGACCGATAAACAAAGAAGCGAAGATAAGAAAGA           AGGCCTCATATCCAATTACCTCACTCATTCACATGTGAGCGACACGCAGACATCCGCGAGGGCCAGCG           TCACCAGACCAGCTGCGGGACAAACCACTCAGACTGCTTGTAGGACAAATACTTCTGACATTTTCGTT           TAAGCAAATACAGGTGCATTTAAAACACGACTTTGGGGGTGATTTGTGTGTAGCGCCTGGGGAGGGGG           GATAAAAGAGGAGGAGTGAGCACTGGAAATACTTTTTAAAGAAAAAAAAACATGAGGGAATAAAAGAA           ATTCCTATCAAAAATCAAAGTGAAATAATACCATCCAGCACTTAACTCTCAGGTCCCAACTAAGTCTG           GCCTGAGCTAATTTATTTGAGCGCAGAGTGTAAAATTTAATTCAAAATGGTGGCTATAATCACTACAC           ATAAATTTCATACTCTTTTGTCTTTGGAGATTCCATTGTGGACAGTAATACGCAGTTACAGGGTGTAG           TCTGTTTAGATTCCGTAGTTCGTGGGTATCAGTTTCGGTAGAGGTGCAGCATCGTGACACTTTTGCTA           ACAGGTACCACTTCTGATCACCCTGTACATACATGAGCCGAAAGGCACAATCACTGTTTCAGATTTAA           AATTATTAGTGTGTTTGTTTGGTCCAGAAACTGAGACAATCACATGACAGTCACCACGAGGAGAGAAA           ATTTAAAAAATAAAAATAAAAACAAAAAAAATTTTAAAAATTAAAAAAACAAAAATAAAGTCTAATAA           GAACTTTGGTACAGGAACTTTTTTGTAATATACATGTATGAATTGTTCATCGAGTTTTTATATTAATT           TTAATTTGCTGCTAAGCAAAGACTAGGGACAGGCAAAGATAATTTATGGCAAAGTGTTTAAATTGTTT           ATACATAAATAAAGTCTCTAAAACTCCTGTG                                                   NOV7o, CG50426-08   SEQ ID NO: 142   2733 aa   MW at 303423.3kD               Protein Sequence                     MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRE           SDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGI       KSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSN       TSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNR       NSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLT       SGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKNSSIDSG       EAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEK       WSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGE       CVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCID       GNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTG       LCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECRE       GWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGD       GLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFN       SSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERT       VWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIE       LPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLASTFIWDKT       DAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILHKG       TGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFNYIRRIFPS       RNVTSILELRNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTG       EQCLPFDEARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPL       SCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLA       IHSALESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSGDDAY       ATDAILNSPSSLAVAPDGTIYIADLGNIRIRVSKNKPXTLNAFNQYEAASPGEQELYVFNADGIHQYT       VSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQ       NLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRD       DDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNIS       LPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVG       RPFLWLPSSGLAAVNVSYFFNGRIAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLL       QSQRQYIFEYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLG       TGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSE       EGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMT       LSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVN       DRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGL       LTRAYNKASGWSVQYRYDGVGRRASYKTNLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGH       LFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTK       LVHFTQRDYDVLAGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQ       LSNIIPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASIREKA       GHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKDTHYFVKIG       SADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYSTLLLSIRYGLTPDTLDEEKA       RVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSS       NIQFLRQNEMGKR                                             Nov7p, CG50426-09   SEQ ID NO: 143   1920 bp               DNA Sequence   ORF Start: at 180   ORF Stop: at 1920                       CCAGCATTAGATGAGTTGACAAAAATGCAGTTTCAGCTCTGAAGGTCTGAAAGATTCTGCTGCAACTA               AAGCTCTGAAGATTCTGCTACAACTATGACATCCATTTTCTCCCACTTCAGACAGGATGAATACAAGG           TGGCAAAGTGACAAGTGCCAAAACTCAGGCCTGACTTTCCTGA AAACATCAGCATTCTGCCATATCTG       GAATAATGGATGTAAAGGACCGGCGACACCGCTCTTTGACCAGAGGACGCTGTGGCAAAGAGTGTCGC       TACACAAGCTCCTCTCTGGACAGTGAGGACTGCCGGGTGCCCACACAGAAATCCTACAGCTCCAGTGA       GACTCTGAAGGCCTATGACCATGACAGCAGGATGCACTATGGAAACCGAGTCACAGACCTCATCCACC       GGGAGTCAGATGAGTTTCCTAGACAAGGAACCAACTTCACCCTTGCCGAACTGGGCATCTGTGAGCCC       TCCCCACACCGAAGCGGCTACTGCTCCGACATGGGGATCCTTCACCAGGGCTACTCCCTTAGCACAGG       GTCTGACGCCGACTCCGACACCGAGGGAGGGATGTCTCCAGAACACGCCATCAGACTGTGGGGCAGAG       GGATAAAATCCAGGCGCAGTTCCGGCCTGTCCAGTCGTGAAAACTCGGCCCTTACCCTGACTGACTCT       GACAACGAAAACAAATCAGATGATGAGAACGGTCGTCCCATTCCACCTACATCCTCGCCTAGTCTCCT       CCCATCTGCTCAGCTGCCTAGCTCCCATAATCCTCCACCAGTTAGCTGCCAGATGCCATTGCTAGACA       GCAACACCTCCCATCAAATCATGGACACCAACCCTGATGAGGAATTCTCCCCCAATTCATACCTGCTC       AGAGCATGCTCAGGGCCCCAGCAAGCCTCCAGCAGTGGCCCTCCGAACCACCACAGCCAGTCGACTCT       GAGGCCCCCTCTCCCACCCCCTCACAACCACACGCTGTCCCATCACCACTCGTCCGCCAACTCCCTCA       ACAGGAACTCACTGACCAATCGGCGGAGTCAGATCCACGCCCCGGCCCCAGCGCCCAATGACCTGGCC       ACCACACCAGAGTCCGTTCAGCTTCAGGACAGCTGGGTGCTAAACAGCAACGTGCCACTGGAGACCCG       GCACTTCCTCTTCAAGACCTCCTCGGGGAGCACACCCTTGTTCAGCAGCTCTTCCCCGGGATACCCTT       TGACCTCAGGAACGGTTTACACGCCCCCGCCCCGCCTGCTGCCCAGGAATACTTTCTCCAGGAAGGCT       TTCAAGCTGAAGAAGCCCTCCAAATACTGCAGCTGGAAATGTGCTGCCCTCTCCGCCATTGCCGCGGC       CCTCCTCTTGGCTATTTTGCTGGCGTATTTCATAGTGCCCTGGTCGTTGAAAAACAGCAGCATAGACA       GTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGGGGTGTTTTGGAGGTCACAA       ATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGAAGGACGCTCTCTTTGGTGT       TTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTATGACTTCATGGAACGTCTGGACGGGAAGG       AGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGACCTTGGTTCAGAATGAAGCC       GTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACAATGATGGAAAAGACAAAGA       GATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCAGGACTGTCCACGTAACTGCCATGGGAATG       GTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGCAGACTGTGCTAAAGCTGCC       TGCCCTGTCCTGTGCA                                                 NOV7p, CG50426-09   SEQ ID NO: 144   580 aa   MW at 63961.7kD               Protein Sequence                     KHQHSAISGIMDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSPNHYG           NRVTDLIHRESDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPE       HAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPV       SCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSH       HHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLF       SSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPW       SLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHTSQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYD       FMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQD       CPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLC                                             NOV7q, CG50426-10   SEQ ID NO: 145   9756 bp               DNA Sequence   ORF Start: ATG at 210   ORF Stop: TAA at 8409                       CCAGCATTAGATGAGTTGACAAAAATGCAGTTTCAGCTCTGAAGGTCTGAAAGATTCTGCTGCAACTA               AAGCTCTGAAGATTCTGCTACAACTATGACATCCATTTTCTCCCACTTCAGACAGGATGAATACAAGG           TGGCAAAGTGACAAGTGCCAAAACTCAGGCCTGACTTTTCTGAAAACATCAGCATTCTGCCATATCTG           GAATA   ATG GATGTAAAGGACCGGCGACACCGCTCTTTGACCAGAGGACGCTGTGGCAAAGAGTGTCGC       TACACAAGCTCCTCTCTGGACAGTGAGGACTGCCGGGTGCCCACACAGAAATCCTACAGCTCCAGTGA       GACTCTGAAGGCCTATGACCATGACAGCAGGATGCACTATGGAAACCGAGTCACAGACCTCATCCACC       GGGAGTCAGATGAGTTTCCTAGACAAGGAACCAACTTCACCCTTGCCGAACTGGGCATCTGTGAGCCC       TCCCCACACCGAAGCGGCTACTGCTCCGACATGGGGATCCTTCACCAGGGCTACTCCCTTAGCACAGG       GTCTGACGCCGACTCCGACACCGAGGGAGGGATGTCTCCAGAACACGCCATCAGACTGTGGGGCAGAG       GGATAAAATCCAGGCGCAGTTCCGGCCTGTCCAGTCGTGAAAACTCGGCCCTTACCCTGACTGACTCT       GACAACGAAAACAAATCAGATGATGAGAACGGTCGTCCCATTCCACCTACATCCTCGCCTAGTCTCCT       CCCATCTGCTCAGCTGCCTAGCTCCCATAATCCTCCACCAGTTAGCTGCCAGATGCCATTGCTAGACA       GCAACACCTCCCATCAAATCATGGACACCAACCCTGATGAGGAATTCTCCCCCAATTCATACCTGCTC       AGAGCATGCTCAGGGCCCCAGCAAGCCTCCAGCAGTGGCCCTCCGAACCACCACAGCCAGTCGACTCT       GAGGCCCCCTCTCCCACCCCCTCACAACCACACGCTGTCCCATCACCACTCGTCCGCCAACTCCCTCA       ACAGGAACTCACTGACCAATCGGCGGAGTCAGATCCACGCCCCGGCCCCAGCGCCCAATGACCTGGCC       ACCACACCAGAGTCCGTTCAGCTTCAGGACAGCTGGGTGCTAAACAGCAACGTGCCACTGGAGACCCG       GCACTTCCTCTTCAAGACCTCCTCGGGGAGCACACCCTTGTTCAGCAGCTCTTCCCCGGGATACCCTT       TGACCTCAGGAACGGTTTACACGCCCCCGCCCCGCCTGCTGCCCAGGAATACTTTCTCCAGGAAGGCT       TTCAAGCTGAAGAAGCCCTCCAAATACTGCAGCTGGAAATGTGCTGCCCTCTCCGCCATTGCCGCGGC       CCTCCTCTTGGCTATTTTGCTGGCGTATTTCATAGTGCCCTGGTCGTTGAAAAACAGCAGCATAGACA       GTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGGGGTGTTTTGGAGGTCACAA       ATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGAAGGACGCTCTCTTTGGTGT       TTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTATGACTTCATGGAACGTCTGGACGGGAAGG       AGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGACCTTGGTTCAGAATGAAGCC       GTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACAATGATGGAAAAGACAAAGA       GATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCAGGACTGTCCACGTAACTGCCATGGGAATG       GTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGCAGACTGTGCTAAAGCTGCC       TGCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAAGGGACGTGCCAGTGCTACAGCGGCTGGAA       AGGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGATCCTTCCTGCGGGGGCCACGGCTCCTGCA       TTGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCGAGCACTGTGAGGAAGTTGATTGCTTGGAT       CCCACCTGCTCCAGCCACGGAGTCTGTGTGAATGGAGAATGCCTGTGCAGCCCTGGCTGGGGTGGTCT       GAACTGTGAGCTGGCGAGGGTCCAGTGCCCAGACCAGTGCAGTGGGCATGGCACGTACCTGCCTGACA       CGGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCGACTGCTCTGTTGAAGTGTGCTCAGTAGAC       TGTGGCACTCACGGCGTCTGCATCGGGGGAGCCTGCCGCTGTGAAGAGGGCTGGACAGGCGCAGCGTG       TGACCAGCGCGTGTGCCACCCCCGCTGCATTGAGCACGGGACCTGTAAAGATGGCAAATGTGAATGCC       GAGAGGGCTGGAATGGTGAACACTGCACCATTGGTAGGCAAACGGCAGGCACCGAAACAGATGGCTGC       CCTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGTCAGAACAGCTGGCAGTGTGTCTGCCAGAC       CGGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAACTTCCTGTGCTGATAACAAGGATAATGAGG       GAGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCCTGCAGTCAGCCTGTCAGAACAGCCTGCTC       TGCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAGGGCCAGACGGATTGGCCCGCAGTGAAGTC       CTTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAGCACCCACATCATTCCTGGAGAGAACCCTT       TCAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAGTAACTACAGATGGAACTCCCCTGGTCAAT       GTGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTACACCATCACCCGCCAGGATGGCACGTTCGA       CCTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTTTGAGCGAGCCCCGTTCATGAGCCAGGAGC       GCACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGGACACCCTGGTGATGAAGACCGAGGAGAAC       TCCATCCCCAGCTGTGACCTCAGTGGCTTTGTCCGGCCTGATCCAATCATCATCTCCTCCCCACTGTC       CACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGTGCCTGAGACCCAGGTTCTTCATGAAGAAA       TCGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGAGCTCTAGAACTGCAGGGTACAAGTCACTG       CTGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAACCTCATTAGGGTTCACCTGATGGTGGCTGT       CGAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCCCAACCTGGCCTCCACCTTCATCTGGGACA       AGACAGATGCGTATGGCCAAAGGGTGTATGGACTCTCAGATGCTGTTGTGTCTGTCGGGTTTGAATAT       GAGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACAGCCCTCCTTCAGGGATTCGAGCTGGACCC       CTCCAACCTCGGTGGCTGGTCCCTAGACAACACCACATCCTCAATGTTAAAAGTGGAAATCCTACACA       AAGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTGCCATCATCACCAGCATCATGGGCAATGGT       CGCCGCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTTGCTGAAGGCAACAAGCTGCTGGCCCCAGT       GGCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGGTGACTTCAATTACATCCGACGCATCTTTC       CCTCTCGAAATGTGACCAGCATCTTGGAGTTACGAAATAAAGAGTTTAAACATAGCAACAACCCAGCA       CACAAGTACTACTTGGCAGTGGACCCCGTGTCCGGCTCGCTCTACGTGTCCGACACCAACAGCAGGAG       AATCTACCGCGTCAAGTCTCTGAGTGGAACCAAAGACCTGGCTGGGAATTCGGAAGTTGTGGCAGGGA       CGGGAGAGCAGTGTCTACCCTTTGATGAAGCCCGCTGCGGGGATGGAGGGAAGGCCATAGATGCAACC       CTGATGAGCCCGAGAGGTATTGCAGTAGACAAGAATGGGCTCATGTACTTTGTCGATGCCACCATGAT       CCGGAAGGTTGACCAGAATGGAATCATCTCCACCCTGCTGGGCTCCAATGACCTCACTGCCGTCCGGC       CGCTGAGCTGTGATTCCAGCATGGATGTAGCCCAGGTTCGTCTGGAGTGGCCAACAGACCTTGCTGTC       AATCCCATGGATAACTCCTTGTATGTTCTAGAGAACAATGTCATCCTTCGAATCACCGAGAACCACCA       AGTCAGCATCATTGCGGGACGCCCCATGCACTGCCAAGTTCCTGGCATTGACTACTCACTCAGCAAAC       TAGCCATTCACTCTGCCCTGGAGTCAGCCAGTGCCATTGCCATTTCTCACACTGGGGTCCTCTACATC       ACTGAGACAGATGAGAAGAAGATTAACCGTCTACGCCAGGTAACAACCAACGGGGAGATCTGCCTTTT       AGCTGGGGCAGCCTCGGACTGCGACTGCAAAAACGATGTCAATTGCAACTAATATTCAGGAGATGATG       CCTACGCGACTGATGCCATCTTGAATTCCCCATCATCCTTAGCTGTAGCTCCAGATGGTACCATTTAC       ATTGCAGACCTTGGAAATATTCGGATCAGGGCGGTCAGCAAGAACAAGCCTGTTCTTAATGCCTTCAA       CCAGTATGAGGCTGCATCCCCCGGAGAGCAGGAGTTATATGTTTTCAACGCTGATGGCATCCACCAAT       ACACTGTGAGCCTGGTGACAGGGGAGTACTTGTACAATTTCACATATAGTACTGACAATGATGTCACT       GAATTGATTGACAATAATGGGAATTCCCTGAAGATCCGTCGGGACAGCAGTGGCATGCCCCGTCACCT       GCTCATGCCTGACAACCAGATCATCACCCTCACCGTGGGCACCAATGGAGGCCTCAAAGTCGTGTCCA       CACAGAACCTGGAGCTTGGTCTCATGACCTATGATGGCAACACTGGGCTCCTGGCCACCAAGAGCGAT       GAAACAGGATGGACGACTTTCTATGACTATGACCACGAAGGCCGCCTGACCAACGTGACAAGCCCCAC       GGGGGTGGTAACCAGTCTGCACCGGGAAATGGAGAAATCTATTACCATTGACATTGAGAACTCCAACC       GTGATGATGACGTCACTGTCATCACCAACCTCTCTTCAGTAGAGGCCTCCTACACAGTGGTACAAGAT       CAAGTTCGGAACAGCTACCAGCTCTGTAATAATGGTACCCTGAGGGTGATGTATGCTAATGGGATGGG       TATCAGCTTCCACAGCGAGCCCCATGTCCTAGCGGGCACCATCACCCCCACCATTGGACGCTGCAACA       TCTCCCTGCCTATGGAGAATGGCTTAAACTCCATTGAGTGGCGCCTAAGAAAGGAACAGATTAAAGGC       AAAGTCACCATCTTTGGCAGGAAGCTCCGGGTCCATGGAAGAAATCTCTTGTCCATTGACTATGATCG       AAATATTCGGACTGAAAAGATCTATGATGACCACCGGAAGTTCACCCTGAGGATCATTTATGACCAGG       TGGGCCGCCCCTTCCTCTGGCTGCCCAGCAGCGGGCTGGCAGCTGTCAACGTGTCATACTTCTTCAAT       GGGCGCCTGGCTGGGCTTCAGCGTGGGGCCATGAGCGAGAGGACAGACATCGACAAGCAAGGCCGCAT       CGTGTCCCGCATGTTCGCTGACGGGAAAGTGTGGAGCTACTCCTACCTTGACAAGTCCATGGTCCTCC       TGCTTCAGAGCCAACGTCAGTATATATTTGAGTATGACTCCTCTGACCGCCTCCTTGCCGTCACCATG       CCCAGCGTGGCCCGGCACAGCATGTCCACACACACCTCCATCGGCTACATCCGTAATATTTACAACCC       GCCTGAAAGCAATGCTTCGGTCATCTTTGACTACAGTGATGACGGCCGCATCCTGAAGACCTCCTTTT       TGGGCACCGGACGCCAGGTGTTCTACAAGTATGGGAAACTCTCCAAGTTATCAGAGATTGTCTACGAC       AGTACCGCCGTCACCTTCGGGTATGACGAGACCACTGGTGTCTTGAAGATGGTCAACCTCCAAAGTGG       GGGCTTCTCCTGCACCATCAGGTACCGGAAGATTGGCCCCCTGGTGGACAAGCAGATCTACAGGTTCT       CCGAGGAAGGCATGGTCAATGCCAGGTTTGACTACACCTATCATGACAACAGCTTCCGCATCGCAAGC       ATCAAGCCCGTCATAAGTGAGACTCCCCTCCCCGTTGACCTCTACCGCTATGATGAGATTTCTGGCAA       GGTGGAACACTTTGGTAAGTTTGGAGTCATCTATTATGACATCAACCAGATCATCACCACTGCCGTGA       TGACCCTCAGCAAACACTTCGACACCCATGGGCGGATCAAGGAGGTCCAGTATGAGATGTTCCGGTCC       CTCATGTACTGGATGACGGTGCAATATGACAGCATGGGCAGGGTGATCAAGAGGGAGCTAAAACTGGG       GCCCTATGCCAATACCACGAAGTACACCTATGACTACGATGGGGACGGGCAGCTCCAGAGCGTGGCCG       TCAATGACCGCCCGACCTGGCGCTACAGCTATGACCTTAATGGGAATCTCCACTTACTGAACCCAGGC       AACAGTGTGCGCCTCATGCCCTTGCGCTATGACCTCCGGGATCGGATAACCAGACTCGGGGATGTGCA       GTACAAAATTGACGACGATGGCTATCTGTGCCAGAGAGGGTCTGACATCTTCGAATACAATTCCAAGG       GCCTCCTAACAAGAGCCTACAACAAGGCCAGCGGGTGGAGTGTCCAGTACCGCTATGATGGCGTAGGA       CGGCGGGCTTCCTACAAGACCAACCTGGGCCACCACCTGCAGTACTTCTACTCTGACCTCCACAACCC       GACGCGCATCACCCATGTCTACAATCACTCCAACTCGGAGATTACCTCACTGTACTACGACCTCCAGG       GCCACCTCTTTGCCATGGAGAGCAGCAGTGGGGAGGAGTACTATGTTGCCTCTGATAACACAGGGACT       CCTCTGGCTGTGTTCAGCATCAACGGCCTCATGATCAAACAGCTGCAGTACACGGCCTATGGGGAGAT       TTATTATGACTCCAACCCCGACTTCCAGATGGTCATTGGCTTCCATGGGGGACTCTATGACCCCCTGA       CCAAGCTGGTCCACTTCACTCAGCGTGATTATGATGTGCTGGCAGGACGATGGACCTCCCCAGACTAT       ACCATGTGGAAAAACGTGGGCAAGGAGCCGGCCCCCTTTAACCTGTATATGTTCAAGAGCAACAATCC       TCTCAGCAGTGAGCTAGATTTGAAGAACTACGTGACAGATGTGAAAAGCTGGCTTGTGATGTTTGGAT       TTCAGCTTAGCAACATCATTCCTGGCTTCCCGAGAGCCAAAATGTATTTCGTGCCTCCTCCCTATGAA       TTGTCAGAGAGTCAAGCAAGTGAGAATGGACAGCTCATTACAGGTGTCCAACAGACAACAGAGAGACA       TAACCAGGCCTTCATGGCTCTGGAAGGACAGGTCATTACTAAAAAGCTCCACGCCAGCATCCGAGAGA       AAGCAGGTCACTGGTTTGCCACCACCACGCCCATCATTGGCAAAGGCATCATGTTTGCCATCAAAGAA       GGGCGGGTGACCACGGGCGTGTCCAGCATCGCCAGCGAAGATAGCCGCAAGGTGGCATCTGTGCTGAA       CAACGCCTACTACCTGGACAAGATGCACTACAGCATCGAGGGCAAGGACACCCACTACTTTGTGAAGA       TTGGCTCAGCCGATGGCGACCTGGTCACACTAGGCACCACCATCGGCCGCAAGGTGCTAGAGAGCGGG       GTGAACGTGACCGTGTCCCAGCCCACGCTGCTGGTCAACGGCAGGACTCGAAGGTTCACGAACATTGA       GTTCCAGTACTCCACGCTGCTGCTCAGCATCCGCTATGGCCTCACCCCCGACACCCTGGACGAAGAGA       AGGCCCGCGTCCTGGACCAGGCGAGACAGAGGGCCCTGGGCACGGCCTGGGCCAAGGAGCAGCAGAAA       GCCAGGGACGGGAGAGAGGGGAGCCGCCTGTGGACTGAGGGCGAGAAGCAGCAGCTTCTGAGCACCGG       GCGCGTGCAAGGGTACGAGGGATATTACGTGCTTCCCGTGGAGCAATACCCAGAGCTTGCAGACAGTA       GCAGCAACATCCAGTTTTTAAGACAGAATGAGATGGGAAAGAGG TAA   CAAAATAATCTGCTGCCATTC           CTTGTCTGAATGGCTCAGCAGGAGTAACTGTTATCTCCTCTCCTAAGGAGATGAAGACCTAACAGGGG           CACTGCGGCTGGGCTGCTTTAGGAGACCAAGTGGCAAGAAAGCTCACATTTTTTGAGTTCAAATGCTA           CTGTCCAAGCGAGAAGTCCCTCATCCTGAAGTAGACTAAAGCCCGGCTGAAAATTCCGAGGAAAACAA           AACAAACGAATGAATGAACAGACACACACAATGTTCCAAGTTCCCCTAAAATATGACCCACTTGTTCT           GGGTCTACGCAGAAAAGAGACGCAAAGTGTCCAAAAGGAACAAAAGAACAAAAACGAATAAGCAAAGA           AGAAAACAAACAAAAACAAAACAAAACAAACACACGGACCGATAAACAAAGAAGCGAAGATAAGAAAG           AAGGCCTCATATCCAATTACCTCACTCATTCACATGTGAGCGACACGCAGACATCCGCGAGGGCCAGC           GTCACCAGACCAGCTGCGGGACAAACCACTCAGACTGCTTGTAGGACAAATACTTCTGACATTTTCGT           TTAAGCAAATACAGGTGCATTTAAAACACGACTTTGGGGGTGATTTGTGTGTAGCGCCTGGGGAGGGG           GGATAAAAGAGGAGGAGTGAGCACTGGAAATACTTTTTAAAGAAAAAAAAACATGAGGGAATAAAAGA           AATTCCTATCAAAAATCAAAGTGAAATAATACCATCCAGCACTTAACTCTCAGGTCCCAACTAAGTCT           GGCCTGAGCTAATTTATTTGAGCGCAGAGTGTAAAATTTAATTCAAAATGGTGGCTATAATCACTACA           GATAAATTTCATACTCTTTTGTCTTTGGAGATTCCATTGTGGACAGTAATACGCAGTTACAGGGTGTA           GTCTGTTTAGATTCCGTAGTTCGTGGGTATCAGTTTCGGTAGAGGTGCAGCATCGTGACACTTTTGCT           AACAGGTACCACTTCTGATCACCCTGTACATACATGAGCCGAAAGGCACAATCACTGTTTCAGATTTA           AAATTATTAGTGTGTTTGTTTGGTCCAGAAACTGAGACAATCACATGACAGTCACCACGAGGAGAGAA           AATTTAAAAAATAAAAATAAAAACAAAAAAAATTTTAAAAATTAAAAAAACAAAAATAAAGTCTAATA           AGAACTTTGGTACAGGAACTTTTTTGTAATATACATGTATGAATTGTTCATCGAGTTTTTATATTAAT           TTTAATTTGCTGCTAAGCAAAGACTAGGGACAGGCAAAGATAATTTATGGCAAAGTGTTTAAATTGTT           TATACATAAATAAAGTCTCTAAAACTCCTGTG                                                   NOV7q, CG50426-10   SEQ ID NO: 146   2733 aa   MW at 303423.3kD               Protein Sequence                     MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRE           SDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGI       KSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSN       TSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNR       NSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLT       SGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKNSSIDSG       EAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYTRRGLPPSHAQYDFMERLDGKEK       WSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCNGNGE       CVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCID       GNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTG       LCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIENGTCKDGKCECRE       GWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGD       GLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFN       SSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLTANGGASLTLHFERAPFMSQERT       VWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIE       LPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLASTFIWDKT       DAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILHKG       TGENQFLTQQPAIITSTMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFNYIRRIFPS       RNVTSILELRNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTG       EQCLPFDEARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPL       SCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLA       IHSALESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSGDDAY       ATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYT       VSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQITTLTVGTNGGLKVVSTQ       NLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRD       DDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNIS       LPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVG       RPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLL       QSQRQYIFEYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLG       TGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYPYIGPLVDKQIYRFSE       EGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMT       LSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVN       DRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGL       LTRAYNKASGWSVQYRYDGVGRRASYKTNLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGH       LFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVTGFHGGLYDPLTK       LVHFTQRDYDVLAGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQ       LSNIIPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASIREKA       GHWFATTTPIIGKGIMFATKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKDTHYFVKIG       SADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYSTLLLSIRYGLTPDTLDEEKA       RVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSS       NIQFLRQNEMGKR                                             NOV7r, CG50426-11   SEQ ID NO: 147   9729 bp               DNA Sequence   ORF Start: ATG at 210   ORF Stop: TAA at 8382                       CCAGCATTAGATGAGTTGACAAAAATGCAGTTTCAGCTCTGAAGGTCTGAAAGATTCTGCTGCAACTA               AAGCTCTGAAGATTCTGCTACAACTATGACATCCATTTTCTCCCACTTCAGACAGGATGAATACAAGG           TGGCAAAGTGACAAGTGCCAAAACTCAGGCCTGACTTTCCTGAAAACATCAGCATTCTGCCATATCTG           GAATA   ATG GATGTAAAGGACCGGCGACACCGCTCTTTGACCAGAGGACGCTGTGGCAAAGAGTGTCGC       TACACAAGCTCCTCTCTGGACAGTGAGGACTGCCGGGTGCCCACACAGAAATCCTACAGCTCCAGTGA       GACTCTGAAGGCCTATGACCATGACAGCAGGATGCACTATGGAAACCGAGTCACAGACCTCATCCACC       GGGAGTCAGATGAGTTTCCTAGACAAGGAACCAACTTCACCCTTGCCGAACTGGGCATCTGTGAGCCC       TCCCCACACCGAAGCGGCTACTGCTCCGACATGGGGATCCTTCACCAGGGCTACTCCCTTAGCACAGG       GTCTGACGCCGACTCCGACACCGAGGGAGGGATGTCTCCAGAACACGCCATCAGACTGTGGGGCAGAG       GGATAAAATCCAGGCGCAGTTCCGGCCTGTCCAGTCGTGAAAACTCGGCCCTTACCCTGACTGACTCT       GACAACGAAAACAAATCAGATGATGAGAACGGTCGTCCCATTCCACCTACATCCTCGCCTAGTCTCCT       CCCATCTGCTCAGCTGCCTAGCTCCCATAATCCTCCACCAGTTAGCTGCCAGATGCCATTGCTAGACA       GCAACACCTCCCATCAAATCATGGACACCAACCCTGATGAGGAATTCTCCCCCAATTCATACCTGCTC       AGAGCATGCTCAGGGCCCCAGCAAGCCTCCAGCAGTGGCCCTCCGAACCACCACAGCCAGTCGACTCT       GAGGCCCCCTCTCCCACCCCCTCACAACCACACGCTGTCCCATCACCACTCGTCCGCCAACTCCCTCA       ACAGGAACTCACTGACCAATCGGCGGAGTCAGATCCACGCCCCGGCCCCAGCGCCCAATGACCTGGCC       ACCACACCAGAGTCCGTTCAGCTTCAGGACAGCTGGGTGCTAAACAGCAACGTGCCACTGGAGACCCG       GCACTTCCTCTTCAAGACCTCCTCGGGGAGCACACCCTTGTTCAGCAGCTCTTCCCCGGGATACCCTT       TGACCTCAGGAACGGTTTACACGCCCCCGCCCCGCCTGCTGCCCAGGAATACTTTCTCCAGGAAGGCT       TTCAAGCTGAAGAAGCCCTCCAAATACTGCAGCTGGAAATGTGCTGCCCTCTCCGCCATTGCCGCGGC       CCTCCTCTTGGCTATTTTGCTGGCGTATTTCATAGTGCCCTGGTCGTTGAAAAACAGCAGCATAGACA       GTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGGGGTGTTTTGGAGGTCACAA       ATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGAAGGACGCTCTCTTTGGTGT       TTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTATGACTTCATGGAACGTCTGGACGGGAAGG       AGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGACCTTGGTTCAGAATGAAGCC       GTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACAATGATGGAAAAGACAAAGA       GATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCAGGACTGTCCACGTAACTGCCATGGGAATG       GTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGCAGACTGTGCTAAAGCTGCC       TGCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAAGGGACGTGCCAGTGCTACAGCGGCTGGAA       AGGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGATCCTTCCTGCGGGGGCCACGGCTCCTGCA       TTGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCGAGCACTGTGAGGAAGTTGATTGCTTGGAT       CCCACCTGCTCCAGCCACGGAGTCTGTGTGAATGGAGAATGCCTGTGCAGCCCTGGCTGGGGTGGTCT       GAACTGTGAGCTGGCGAGGGTCCAGTGCCCAGACCAGTGCAGTGGGCATGGCACGTACCTGCCTGACA       CGGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCGACTGCTCTGTTGAAGTGTGCTCAGTAGAC       TGTGGCACTCACGGCGTCTGCATCGGGGGAGCCTGCCGCTGTGAAGAGGGCTGGACAGGCGCAGCGTG       TGACCAGCGCGTGTGCCACCCCCGCTGCATTGAGCATGGGACCTGTAAAGATGGCAAATGTGAATGCC       GAGAGGGCTGGAATGGTGAACACTGCACCATTGATGGCTGCCCTGACTTGTGCAACGGTAACGGGAGA       TGCACACTGGGTCAGAACAGCTGGCAGTGTGTCTGCCAGACCGGCTGGAGAGGGCCCGGATGCAACGT       TGCCATGGAAACTTCCTGTGCTGATAACAAGGATAATGAGGGAGATGGCCTGGTGGATTGTTTGGACC       CTGACTGCTGCCTGCAGTCAGCCTGTCAGAACAGCCTGCTCTGCCGGGGGTCCCGGGACCCACTGGAC       ATCATTCAGCAGGGCCAGACGGATTGGCCCGCAGTGAAGTCCTTCTATGACCGTATCAAGCTCTTGGC       AGGCAAGGATAGCACCCACATCATTCCTGGAGAGAACCCTTTCAACAGCAGCTTGGTTTCTCTCATCC       GAGGCCAAGTAGTAACTACAGATGGAACTCCCCTGGTCGGTGTGAACGTGTCTTTTGTCAAGTACCCA       AAATACGGCTACACCATCACCCGCCAGGATGGCACGTTCGACCTGATCGCAAATGGAGGTGCTTCCTT       GACTCTACACTTTGAGCGAGCCCCGTTCATGAGCCAGGAGCGCACTGTGTGGCTGCCGTGGAACAGCT       TTTACGCCATGGACACCCTGGTGATGAAGACCGAGGAGAACTCCATCCCCAGCTGTGACCTCAGTGGC       TTTGTCCGGCCTGATCCAATCATCATCTCCTCCCCACTGTCCACCTTCTTTAGTGCTGCCCCTGGGCA       GAATCCCATCGTGCCTGAGACCCAGGTTCTTCATGAAGAAATCGAGCTCCCTGGTTCCAATGTGAAAC       TTCGCTATCTGAGCTCTAGAACTGCAGGGTACAAGTCACTGCTGAAGATCACCATGACCCAGTCCACA       GTGCCCCTGAACCTCATTAGGGTTCACCTGATGGTGGCTGTCGAGGGGCATCTCTTCCAGAAGTCATT       CCAGGCTTCTCCCAACCTGGCCTCCACCTTCATCTGGGACAAGACAGATGCGTATGGCCAAAGGGTGT       ATGGACTCTCAGATGCTGTTGTGTCTGTCGGGTTTGAATATGAGACCTGTCCCAGTCTAATTCTCTGG       GAGAAAAGGACAGCCCTCCTTCAGGGATTCGAGCTGGACCCCTCCAACCTCGGTGGCTGGTCCCTAGA       CAAACACCACATCCTCAATGTTAAAAGTGGAATCCTACACAAAGGCACTGGGGAAAACCAGTTCCTGA       CCCAGCAGCCTGCCATCATCACCAGCATCATGGGCAATGGTCGCCGCCGGAGCATTTCCTGTCCCAGC       TGCAACGGCCTTGCTGAAGGCAACAAGCTGCTGGCCCCAGTGGCTCTGGCTGTTGGAATCGATGGGAG       CCTCTATGTGGGTGACTTCAATTACATCCGACGCATCTTTCCCTCTCGAAATGTGACCAGCATCTTGG       AGTTACGAAATAAAGAGTTTAAACATAGCAACAACCCAGCACACAAGTACTACTTGGCAGTGGACCCC       GTGTCCGGCTCGCTCTACGTGTCCGACACCAACAGCAGGAGAATCTACCGCGTCAAGTCTCTGAGTGG       AACCAAAGACCTGGCTGGGAATTCGGAAGTTGTGGCAGGGACGGGAGAGCAGTGTCTACCCTTTGATG       AAGCCCGCTGCGGGGATGGAGGGAAGGCCATAGATGCAACCCTGATGAGCCCGAGAGGTATTGCAGTA       GACAAGAATGGGCTCATGTACTTTGTCGATGCCACCATGATCCGGAAGGTTGACCAGAATGGAATCAT       CTCCACCCTGCTGGGCTCCAATGACCTCACTGCCGTCCGGCCGCTGAGCTGTGATTCCAGCATGGATG       TAGCCCAGGTTCGTCTGGAGTGGCCAACAGACCTTGCTGTCAATCCCATGGATAACTCCTTGTATGTT       CTAGAGAACAATGTCATCCTTCGAATCACCGAGAACCACCAAGTCAGCATCATTGCGGGACGCCCCAT       GCACTGCCAAGTTCCTGGCATTGACTACTCACTCAGCAAACTAGCCATTCACTCTGCCCTGGAGTCAG       CCAGTGCCATTGCCATTTCTCACACTGGGGTCCTCTACATCACTGAGACAGATGAGAAGAAGATTAAC       CGTCTACGCCAGGTAACAACCAACGGGGAGATCTGCCTTTTAGCTGGGGCAGCCTCGGACTGCGACTG       CAAAAACGATGTCAATTGCAACTGCTATTCAGGAGATGATGCCTACGCGACTGATGCCATCTTGAATT       CCCCATCATCCTTAGCTGTAGCTCCAGATGGTACCATTTACATTGCAGACCTTGGAAATATTCGGATC       AGGGCGGTCAGCAAGAACAAGCCTGTTCTTAATGCCTTCAACCAGTATGAGGCTGCATCCCCCGGAGA       GCAGGAGTTATATGTTTTCAACGCTGATGGCATCCACCAATACACTGTGAGCCTGGTGACAGGGGAGT       ACTTGTACAATTTCACATATAGTACTGACAATGATGTCACTGAATTGATTGACAATAATGGGAATTCC       CTGAAGATCCGTCGGGACAGCAGTGGCATGCCCCGTCACCTGCTCATGCCTGACAACCAGATCATCAC       CCTCACCGTGGGCACCAATGGAGGCCTCAAAGTCGTGTCCACACAGAACCTGGAGCTTGGTCTCATGA       CCTATGATGGCAACACTGGGCTCCTGGCCACCAAGAGCGATGAAACAGGATGGACGACTTTCTATGAC       TATGACCACGAAGGCCGCCTGACCAACGTGACGCGCCCCACGGGGGTGGTAACCAGTCTGCACCGGGA       AATGGAGAAATCTATTACCATTGACATTGAGAACTCCAACCGTGATGATGACGTCACTGTCATCACCA       ACCTCTCTTCAGTAGAGGCCTCCTACACAGTGGTACAAGATCAAGTTCGGAACAGCTACCAGCTCTGT       AATAATGGTACCCTGAGGGTGATGTATGCTAATGGGATGGGTATCAGCTTCCACAGCGAGCCCCATGT       CCTAGCGGGCACCATCACCCCCACCATTGGACGCTGCAACATCTCCCTGCCTATGGAGAATGGCTTAA       ACTCCATTGAGTGGCGCCTAAGAAAGGAACAGATTAAAGGCAAAGTCACCATCTTTGGCAGGAAGCTC       CGGGTCCATGGAAGAAATCTCTTGTCCATTGACTATGATCGAAATATTCGGACTGAAAAGATCTATGA       TGACCACCGGAAGTTCACCCTGAGGATCATTTATGACCAGGTGGGCCGCCCCTTCCTCTGGCTGCCCA       GCCATGAGCGAGAGGACAGACATCGACAAGCAAGGCCGCATCGTGTCCCGCATGTTCGCTGACGGGAA       AGTGTGGAGCTACTCCTACCTTGACAAGTCCATGGTCCTCCTGCTTCAGAGCCAACGTCAGTATATAT       TTGAGTATGACTCCTCTGACCGCCTCCTTGCCGTCACCATGCCCAGCGTGGCCCGGCACAGCATGTCC       ACACACACCTCCATCGGCTACATCCGTAATATTTACAACCCGCCTGAAAGCAATGCTTCGGTCATCTT       TGACTACAGTGATGACGGCCGCATCCTGAAGACCTCCTTTTTGGGCACCGGACGCCAGGTGTTCTACA       AGTATGGGAAACTCTCCAAGTTATCAGAGATTGTCTACGACAGTACCGCCGTCACCTTCGGGTATGAC       GAGACCACTGGTGTCTTGAAGATGGTCAACCTCCAAAGTGGGGGCTTCTCCTGCACCATCAGGTACCG       GAAGATTGGCCCCCTGGTGGACAAGCAGATCTACAGGTTCTCCGAGGAAGGCATGGTCAATGCCAGGT       TTGACTACACCTATCATGACAACAGCTTCCGCATCGCAAGCATCAAGCCCGTCATAAGTGAGACTCCC       CTCCCCGTTGACCTCTACCGCTATGATGAGATTTCTGGCAAGGTGGAACACTTTGGTAAGTTTGGAGT       CATCTATTATGACATCAACCAGATCATCACCACTGCCGTGATGACCCTCAGCAAACACTTCGACACCC       ATGGGCGGATCAAGGAGGTCCAGTATGAGATGTTCCGGTCCCTCATGTACTGGATGACGGTGCAATAT       GACAGCATGGGCAGGGTGATCAAGAGGGAGCTAAAACTGGGGCCCTATGCCAATACCACGAAGTACAC       CTATGACTACGATGGGGACGGGCAGCTCCAGAGCGTGGCCGTCAATGACCGCCCGACCTGGCGCTACA       GCTATGACCTTAATGGGAATCTCCACTTACTGAACCCAGGCAACAGTGTGCGCCTCATGCCCTTGCGC       TATGACCTCCGGGATCGGATAACCAGACTCGGGGATGTGCAGTACAAAATTGACGACGATGGCTATCT       GTGCCAGAGAGGGTCTGACATCTTCGAATACAATTCCAAGGGCCTCCTAACAAGAGCCTACAACAAGG       CCAGCGGGTGGAGTGTCCAGTACCGCTATGATGGCGTAGGACGGCGGGCTTCCTACAAGACCAACCTG       GGCCACCACCTGCAGTACTTCTACTCTGACCTCCACAACCCGACGCGCATCACCCATGTCTACAATCA       CTCCAACTCGGAGATTACCTCACTGTACTACGACCTCCAGGGCCACCTCTTTGCCATGGAGAGCAGCA       GTGGGGAGGAGTACTATGTTGCCTCTGATAACACAGGGACTCCTCTGGCTGTGTTCAGCATCAACGGC       CTCATGATCAAACAGCTGCAGTACACGGCCTATGGGGAGATTTATTATGACTCCAACCCCGACTTCCA       GATGGTCATTGGCTTCCATGGGGGACTCTATGACCCCCTGACCAAGCTGGTCCACTTCACTCAGCGTG       ATTATGATGTGCTGGCAGGACGATGGACCTCCCCAGACTATACCATGTGGAAAAACGTGGGCAAGGAG       CCGGCCCCCTTTAACCTGTATATGTTCAAGAGCAACAATCCTCTCAGCAGTGAGCTAGATTTGAAGAA       CTACGTGACAGATGTGAAAAGCTGGCTTGTGATGTTTGGATTTCAGCTTAGCAACATCATTCCTGGCT       TCCCGAGAGCCAAAATGTATTTCGTGCCTCCTCCCTATGAATTGTCAGAGAGTCAAGCAAGTGAGAAT       GGACAGCTCATTACAGGTGTCCAACAGACAACAGAGAGACATAACCAGGCCTTCATGGCTCTGGAAGG       ACAGGTCATTACTAAAAAGCTCCACGCCAGCATCCGAGAGAAAGCAGGTCACTGGTTTGCCACCACCA       CGCCCATCATTGGCAAAGGCATCATGTTTGCCATCAAAGAAGGGCGGGTGACCACGGGCGTGTCCAGC       ATCGCCAGCGAAGATAGCCGCAAGGTGGCATCTGTGCTGAACAACGCCTACTACCTGGACAAGATGCA       CTACAGCATCGAGGGCAAGGACACCCACTACTTTGTGAAGATTGGCTCAGCCGATGGCGACCTGGTCA       CACTAGGCACCACCATCGGCCGCAAGGTGCTAGAGAGCGGGGTGAACGTGACCGTGTCCCAGCCCACG       CTGCTGGTCAACGGCAGGACTCGAAGGTTCACGAACATTGAGTTCCAGTACTCCACGCTGCTGCTCAG       CATCCGCTATGGCCTCACCCCCGACACCCTGGACGAAGAGAAGGCCCGCGTCCTGGACCAGGCGAGAC       AGAGGGCCCTGGGCACGGCCTGGGCCAAGGAGCAGCAGAAAGCCAGGGACGGGAGAGAGGGGAGCCGC       CTGTGGACTGAGGGCGAGAAGCAGCAGCTTCTGAGCACCGGGCGCGTGCAAGGGTACGAGGGATATTA       CGTGCTTCCCGTGGAGCAATACCCAGAGCTTGCAGACAGTAGCAGCAACATCCAGTTTTTAAGACAGA       ATGAGATGGGAAAGAGG TAA   CAAAATAATCTGCTGCCATTCCTTGTCTGAATGGCTCAGCAGGAGTAA           CTGTTATCTCCTCTCCTAAGGAGATGAAGACCTAACAGGGGCACTGCGGCTGGGCTGCTTTAGGAGAC           CAAGTGGCAAGAAAGCTCACATTTTTTGAGTTCAAATGCTACTGTCCAAGCGAGAAGTCCCTCATCCT           GAAGTAGACTAAAGCCCGGCTGAAAATTCCGAGGAAAACAAAACAAACGAATGAATGAACAGACACAC           ACAATGTTCCAAGTTCCCCTAAAATATGACCCACTTGTTCTGGGTCTACGCAGAAAAGAGACGCAAAG           TGTCCAAAAGGAACAAAAGAACAAAAACGAATAAGCAAAGAAGAAAACAAACAAAAACAAAACAAAAC           AAACACACGGACCGATAAACAAAGAAGCGAAGATAAGAAAGAAGGCCTCATATCCAATTACCTCACTC           ATTCACATGTGAGCGACACGCAGACATCCGCGAGGGCCAGCGTCACCAGACCAGCTGCGGGACAAACC           ACTCAGACTGCTTGTAGGACAAATACTTCTGACATTTTCGTTTAAGCAAATACAGGTGCATTTAAAAC           ACGACTTTGGGGGTGATTTGTGTGTAGCGCCTGGGGAGGGGGGATAAAAGAGGAGGAGTGAGCACTGG           AAATACTTTTTAAAGAAAAAAAAACATGAGGGAATAAAAGAAATTCCTATCAAAAATCAAAGTGAAAT           AATACCATCCAGCACTTAACTCTCAGGTCCCAACTAAGTCTGGCCTGAGCTAATTTATTTGAGCGCAG           AGTGTAAAATTTAATTCAAAATGGTGGCTATAATCACTACAGATAAATTTCATACTCTTTTGTCTTTG           GAGATTCCATTGTGGACAGTAATACGCAGTTACAGGGTGTAGTCTGTTTAGATTCCGTAGTTCGTGGG           TATCAGTTTCGGTAGAGGTGCAGCATCGTGACACTTTTGCTAACAGGTACCACTTCTGATCACCCTGT           ACATACATGAGCCGAAAGGCACAATCACTGTTTCAGATTTAAAATTATTAGTGTGTTTGTTTGGTCCA           GAAACTGAGACAATCACATGACAGTCACCACGAGGAGAGAAAATTTAAAAAATAAAAATAAAAACAAA           AAAAATTTTAAAAATTAAAAAAACAAAAATAAAGTCTAATAAGAACTTTGGTACAGGAACTTTTTTGT           AATATACATGTATGAATTGTTCATCGAGTTTTTATATTAATTTTAATTTGCTGCTAAGCAAAGACTAG           GGACAGGCAAAGATAATTTATGGCAAAGTGTTTAAATTGTTTATACATAAATAAAGTCTCTAAAACTC           CTGTG                                                   NOV7r, CG50426-11   SEQ ID NO: 148   2724 aa   MW at 302521.3kD               Protein Sequence                     MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRE           SDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGI       KSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSN       TSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNR       NSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLT       SGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKNSSIDSG       EAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEK       WSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGE       CVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCID       GNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTG       LCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECRE       GWNGEHCTIDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPD       CCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIRG       QVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERTVWLPWNSFY       AMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIELPGSNVKLR       YLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLASTFIWDKTDAYGQRVYG       LSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILHKGTGENQFLTQ       QPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFNYIRRIFPSRNVTSILEL       RNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEA       RCGDGGKAIDATLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVA       QVRLEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSALESAS       AIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSGDDAYATDAILNSP       SSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVTGEYL       YNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQNLELGLMTY       DGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNL       SSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNS       IEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSS       GLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQRQYIFE       YDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLGTGRQVFYKY       GKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGpLVDKQIYRFSEEGMVNARFD       YTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHG       RIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSY       DLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKAS       GWSVQYRYDGVGRRASYKTNLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSG       EEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDY       DVLAGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNIIPGFP       RAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASIREKAGHWFATTTP       IIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKDTHYFVKIGSADGDLVTL       GTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYSTLLLSIRYGLTPDTLDEEKARVLDQARQR       ALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNE       MGKR                                             NOV7s, CG50426-12   SEQ ID NO: 149   9826 bp               DNA Sequence   ORF Start: ATG at 280   ORF Stop: TAA at 8479                       TTTAAATCCTCATACCTTAAAGGAGATGTGTATATAAGGGAGTTGGAACCAGCATTAGATGAGTTGAC               AAAAATGCAGTTTCAGTTCTAGAGGTCTGGGAAGTCCAAGAACAAGGTGCTGGCAGATTGGATTCCCC           GTGAGGGCTTTCTTCCTGGCTTGAAGTTGGCTGCTTTCCTGCTGAGACTTCTCATGGCAGAGACTGAG           GGTGGCAAAGTGACAAGTGCCAAAACTCAGGCCTGACTTTTCTGAAAACATCAGCATTCTGCCATATC           TGGAATA   ATG GATGTAAAGGACCGGCGACACCGCTCTTTGACCAGAGGACGCTGTGGCAAAGAGTGTC       GCTACACAAGCTCCTCTCTGGACAGTGAGGACTGCCGGGTGCCCACACAGAAATCCTACAGCTCCAGT       GAGACTCTGAAGGCCTATGACCATGACAGCAGGATGCACTATGGAAACCGAGTCACAGACCTCATCCA       CCGGGAGTCAGATGAGTTTCCTAGACAAGGAACCAACTTCACCCTTGCCGAACTGGGCATCTGTGAGC       CCTCCCCACACCGAAGCGGCTACTGCTCCGACATGGGGATCCTTCACCAGGGCTACTCCCTTAGCACA       GGGTCTGACGCCGACTCCGACACCGAGGGAGGGATGTCTCCAGAACACGCCATCAGACTGTGGGGCAG       AGGGATAAAATCCAGGCGCAGTTCCGGCCTGTCCAGTCGTGAAAACTCGGCCCTTACCCTGACTGACT       CTGACAACGAAAACAAATCAGATGATGAGAACGGTCGTCCCATTCCACCTACATCCTCGCCTAGTCTC       CAGCAACACCTCCCATCAAATCATGGACACCAACCCTGATGAGGAATTCTCCCCCAATTCATACCTGC       TCAGAGCATGCTCAGGGCCCCAGCAAGCCTCCAGCAGTGGCCCTCCGAACCACCACAGCCAGTCGACT       CTGAGGCCCCCTCTCCCACCCCCTCACAACCACACGCTGTCCCATCACCACTCGTCCGCCAACTCCCT       CAACAGGAACTCACTGACCAATCGGCGGAGTCAGATCCACGCCCCGGCCCCAGCGCCCAATGACCTGG       CCACCACACCAGAGTCCGTTCAGCTTCAGGACAGCTGGGTGCTAAACAGCAACGTGCCACTGGAGACC       CGGCACTTCCTCTTCAAGACCTCCTCGGGGAGCACACCCTTGTTCAGCAGCTCTTCCCCGGGATACCC       TTTGACCTCAGGAACGGTTTACACGCCCCCGCCCCGCCTGCTGCCCAGGAATACTTTCTCCAGGAAGG       CTTTCAAGCTGAAGAAGCCCTCCAAATACTGCAGCTGGAAATGTGCTGCCCTCTCCGCCATTGCCGCG       GCCCTCCTCTTGGCTATTTTGCTGGCGTATTTCATAGTGCCCTGGTCGTTGAAAAACAGCAGCATAGA       CAGTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGGGGTGTTTTGGAGGTCAC       AAATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGAAGGACGCTCTCTTTGGT       GTTTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTATGACTTCATGGAACGTCTGGACGGGAA       GGAGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGACCTTGGTTCAGAATGAAG       CCGTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACAATGATGGAAAAGACAAA       GAGATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCAGGACTGTCCACGTAACTGCCATGGGAA       TGGTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGCAGACTGTGCTAAAGCTG       CCTGCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAAGGGACGTGCCAGTGCTACAGCGGCTGG       AAAGGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGATCCTTCCTGCGGGGGCCACGGCTCCTG       CATTGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCGAGCACTGTGAGGAAGTTGATTGCTTGG       ATCCCACCTGCTCCAGCCACGGAGTCTGTGTGAATGGAGAATGCCTGTGCAGCCCTAACTGGGGTGGT       CTGAACTGTGAGCTGGCGAGGGTCCAGTGCCCAGACCAGTGCAGTGGGCATGGCACGTACCTGCCTGA       CACGGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCGACTGCTCTGTTGAAGTGTGCTCAGTAG       ACTGTGGCACTCACGGCGTCTGCATCGGGGGAGCCTGCCGCTGTGAAGAGGGCTGGACAGGCGCAGCG       TGTGACCAGCGCGTGTGCCACCCCCGCTGCATTGAGCACGGGACCTGTAAAGATGGCAAATGTGAATG       CCGAGAGGGCTGGAATGGTGAACACTGCACCATTGGTAGGCAAACGGCAGGCACCGAAACAGATGGCT       GCCCTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGTCAGAACAGCTGGCAGTGTGTCTGCCAG       ACCGGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAACTTCCTGTGCTGATAACAAGGATAATGA       GGGAGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCCTGCAGTCAGCCTGTCAGAACAGCCTGC       TCTGCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAGGGCCAGACGGATTGGCCCAAAGTGAAG       TCCTTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAGCACCCACATCATTCCTGGAGAGAACCC       TTTCAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAGTAACTACAGATGGAACTCCCCTGGTCG       GTGTGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTACACCATCACCCGCCAGGATGGCACGTTC       GACCTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTTTGAGCGAGCCCCGTTCATGAGCCAGGA       GCGCACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGGACACCCTGGTGATGAAGACCGAGGAGA       ACTCCATCCCCAGCTGTGACCTCAGTGGCTTTGTCCGGCCTGATCCAATCATCATCTCCTCCCCACTG       TCCACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGTGCCTGAGACCCAGGTTCTTCATGAAGA       AATCGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGAGCTCTAGAACTGCAGGGTACAAGTCAC       TGCTGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAACCTCATTAGGGTTCACCTGATGGTGGCT       GTCGAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCCCAACCTGGCCTCCACCTTCATCTGGGA       CAAGACAGATGCGTATGGCCAAAGGGTGTATGGACTCTCAGATGCTGTTGTGTCTGTCGGGTTTGAAT       ATGAGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACAGCCCTCCTTCAGGGATTCGAGCTGGAC       CCCTCCAACCTCGGTGGCTGGTCCCTAGACAAACACCACATCCTCAATGTTAAAAGTGGAATCCTACA       CAAAGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTGCCATCATCACCAGCATCATGGGCAATG       GTCGCCGCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTTGCTGAAGGCAACAAGCTGCTGGCCCCA       GTGGCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGGTGACTTCAATTACATCCGACGCATCTT       TCCCTCTCGAAATGTGACCAGCATCTTGGAGTTACGAAATAAAGAGTTTAAACATAGCAACAACCCAG       CACACAAGTACTACTTGGCAGTGGACCCCGTGTCCGGCTCGCTCTACGTGTCCGACACCAACAGCAGG       AGAATCTACCGCGTCAAGTCTCTGAGTGGAACCAAAGACCTGGCTGGGAATTCGGAAGTTGTGGCAGG       GACGGGAGAGCAGTGTCTACCCTTTGATGAAGCCCGCTGCGGGGATGGAGGGAAGGCCATAGATGCAA       CCCTGATGAGCCCGAGAGGTATTGCAGTAGACAAGAATGGGCTCATGTACTTTGTCGATGCCACCATG       ATCCGGAAGGTTGACCAGAATGGAATCATCTCCACCCTGCTGGGCTCCAATGACCTCACTGCCGTCCG       GCCGCTGAGCTGTGATTCCAGCATGGATGTAGCCCAGGTTCGTCTGGAGTGGCCAACAGACCTTGCTG       TCAATCCCATGGATAACTCCTTGTATGTTCTAGAGAACAATGTCATCCTTCGAATCACCGAGAACCAC       CAAGTCAGCATCATTGCGGGACGCCCCATGCACTGCCAAGTTCCTGGCATTGACTACTCACTCAGCAA       ACTAGCCATTCACTCTGCCCTGGAGTCAGCCAGTGCCATTGCCATTTCTCACACTGGGGTCCTCTACA       TCACTGAGACAGATGAGAAGAAGATTAACCGTCTACGCCAGGTAACAACCAACGGGGAGATCTGCCTT       TTAGCTGGGGCAGCCTCGGACTGCGACTGCAAAAACGATGTCAATTGCAACTGCTATTCAGGAGATGA       TGCCTACGCGACTGATGCCATCTTGAATTCCCCATCATCCTTAGCTGTAGCTCCAGATGGTACCATTT       ACATTGCAGACCTTGGAAATATTCGGATCAGGGCGGTCAGCAAGAACAAGCCTGTTCTTAATGCCTTC       AACCAGTATGAGGCTGCATCCCCCGGAGAGCAGGAGTTATATGTTTTCAACGCTGATGGCATCCACCA       ATACACTGTGAGCCTGGTGACAGGGGAGTACTTGTACAATTTCACATATAGTACTGACAATGATGTCA       CTGAATTGATTGACAATAATGGGAATTCCCTGAAGATCCGTCGGGACAGCAGTGGCATGCCCCGTCAC       CTGCTCATGCCTGACAACCAGATCATCACCCTCACCGTGGGCACCAATGGAGGCCTCAAAGTCGTGTC       CACACAGAACCTGGAGCTTGGTCTCATGACCTATGATGGCAACACTGGGCTCCTGGCCACCAAGAGCG       ATGAAACAGGATGGACGACTTTCTATGACTATGACCACGAAGGCCGCCTGACCAACGTGACGCGCCCC       ACGGGGGTGGTAACCAGTCTGCACCGGGAAATGGAGAAATCTATTACCATTGACATTGAGAACTCCAA       CCGTGATGATGACGTCACTGTCATCACCAACCTCTCTTCAGTAGAGGCCTCCTACACAGTGGTACAAG       ATCAAGTTCGGAACAGCTACCAGCTCTGTAATAATGGTACCCTGAGGGTGATGTATGCTAATGGGATG       GGTATCAGCTTCCACAGCGAGCCCCATGTCCTAGCGGGCACCATCACCCCCACCATTGGACGCTGCAA       CATCTCCCTGCCTATGGAGAATGGCTTAAACTCCATTGAGTGGCGCCTAAGAAAGGAACAGATTAAAG       GCAAAGTCACCATCTTTGGCAGGAAGCTCCGGGTCCATGGAAGAAATCTCTTGTCCATTGACTATGAT       CGAAATATTCGGACTGAAAAGATCTATGATGACCACCGGAAGTTCACCCTGAGGATCATTTATGACCA       GGTGGGCCGCCCCTTCCTCTGGCTGCCCAGCAGCGGGCTGGCAGCTGTCAACGTGTCATACTTCTTCA       ATGGGCGCCTGGCTGGGCTTCAGCGTGGGGCCATGAGCGAGAGGACAGACATCGACAAGCAAGGCCGC       ATCGTGTCCCGCATGTTCGCTGACGGGAAAGTGTGGAGCTACTCCTACCTTGACAAGTCCATGGTCCT       CCTGCTTCAGAGCCAACGTCAGTATATATTTGAGTATGACTCCTCTGACCGCCTCCTTGCCGTCACCA       TGCCCAGCGTGGCCCGGCACAGCATGTCCACACACACCTCCATCGGCTACATCCGTAATATTTACAAC       CCGCCTGAAAGCAATGCTTCGGTCATCTTTGACTACAGTGATGACGGCCGCATCCTGAAGACCTCCTT       TTTGGGCACCGGACGCCAGGTGTTCTACAAGTATGGGAAACTCTCCAAGTTATCAGAGATTGTCTACG       ACAGTACCGCCGTCACCTTCGGGTATGACGAGACCACTGGTGTCTTGAAGATGGTCAACCTCCAAAGT       GGGGGCTTCTCCTGCACCATCAGGTACCGGAAGATTGGCCCCCTGGTGGACAAGCAGATCTACAGGTT       CTCCGAGGAAGGCATGGTCAATGCCAGGTTTGACTACACCTATCATGACAACAGCTTCCGCATCGCAA       GCATCAAGCCCGTCATAAGTGAGACTCCCCTCCCCGTTGACCTCTACCGCTATGATGAGATTTCTGGC       AAGGTGGAACACTTTGGTAAGTTTGGAGTCATCTATTATGACATCAACCAGATCATCACCACTGCCGT       GATGACCCTCAGCAAACACTTCGACACCCATGGGCGGATCAAGGAGGTCCAGTATGAGATGTTCCGGT       CCCTCATGTACTGGATGACGGTGCAATATGACAGCATGGGCAGGGTGATCAAGAGGGAGCTAAAACTG       GGGCCCTATGCCAATACCACGAAGTACACCTATGACTACGATGGGGACGGGCAGCTCCAGAGCGTGGC       CGTCAATGACCGCCCGACCTGGCGCTACAGCTATGACCTTAATGGGAATCTCCACTTACTGAACCCAG       GCAACAGTGTGCGCCTCATGCCCTTGCGCTATGACCTCCGGGATCGGATAACCAGACTCGGGGATGTG       CAGTACAAAATTGACGACGATGGCTATCTGTGCCAGAGAGGGTCTGACATCTTCGAATACAATTCCAA       GGGCCTCCTAACAAGAGCCTACAACAAGGCCAGCGGGTGGAGTGTCCAGTACCGCTATGATGGCGTAG       GACGGCGGGCTTCCTACAAGACCAACCTGGGCCACCACCTGCAGTACTTCTACTCTGACCTCCACAAC       CCGACGCGCATCACCCATGTCTACAATCACTCCAACTCGGAGATTACCTCACTGTACTACGACCTCCA       GGGCCACCTCTTTGCCATGGAGAGCAGCAGTGGGGAGGAGTACTATGTTGCCTCTGATAACACAGGGA       CTCCTCTGGCTGTGTTCAGCATCAACGGCCTCATGATCAAACAGCTGCAGTACACGGCCTATGGGGAG       ATTTATTATGACTCCAACCCCGACTTCCAGATGGTCATTGGCTTCCATGGGGGACTCTATGACCCCCT       GACCAAGCTGGTCCACTTCACTCAGCGTGATTATGATGTGCTGGCAGGACGATGGACCTCCCCAGACT       ATACCATGTGGAAAAACGTGGGCAAGGAGCCGGCCCCCTTTAACCTGTATATGTTCAAGAGCAACAAT       CCTCTCAGCAGTGAGCTAGATTTGAAGAACTACGTGACAGATGTGAAAAGCTGGCTTGTGATGTTTGG       ATTTCAGCTTAGCAACATCATTCCTGGCTTCCCGAGAGCCAAAATGTATTTCGTGCCTCCTCCCTATG       AATTGTCAGAGAGTCAAGCAAGTGAGAATGGACAGCTCATTACAGGTGTCCAACAGACAACAGAGAGA       CATAACCAGGCCTTCATGGCTCTGGAAGGACAGGTCATTACTAAAAAGCTCCACGCCAGCATCCGAGA       GAAAGCAGGTCACTGGTTTGCCACCACCACGCCCATCATTGGCAAAGGCATCATGTTTGCCATCAAAG       AAGGGCGGGTGACCACGGGCGTGTCCAGCATCGCCAGCGAAGATAGCCGCAAGGTGGCATCTGTGCTG       AACAACGCCTACTACCTGGACAAGATGCACTACAGCATCGAGGGCAAGGACACCCACTACTTTGTGAA       GATTGGCTCAGCCGATGGCGACCTGGTCACACTAGGCACCACCATCGGCCGCAAGGTGCTAGAGAGCG       GGGTGAACGTGACCGTGTCCCAGCCCACGCTGCTGGTCAACGGCAGGACTCGAAGGTTCACGAACATT       GAGTTCCAGTACTCCACGCTGCTGCTCAGCATCCGCTATGGCCTCACCCCCGACACCCTGGACGAAGA       GAAGGCCCGCGTCCTGGACCAGGCGAGACAGAGGGCCCTGGGCACGGCCTGGGCCAAGGAGCAGCAGA       AAGCCAGGGACGGGAGAGAGGGGAGCCGCCTGTGGACTGAGGGCGAGAAGCAGCAGCTTCTGAGCACC       GGGCGCGTGCAAGGGTACGAGGGATATTACGTGCTTCCCGTGGAGCAATACCCAGAGCTTGCAGACAG       TAGCAGCAACATCCAGTTTTTAAGACAGAATGAGATGGGAAAGAGG TAA   CAAAATAATCTGCTGCCAT           TCCTTGTCTGAATGGCTCAGCAGGAGTAACTGTTATCTCCTCTCCTAAGGAGATGAAGACCTAACAGG           GGCACTGCGGCTGGGCTGCTTTAGGAGACCAAGTGGCAAGAAAGCTCACATTTTTTGAGTTCAAATGC           TACTGTCCAAGCGAGAAGTCCCTCATCCTGAAGTAGACTAAAGCCCGGCTGAAAATTCCGAGGAAAAC           AAAACAAACGAATGAATGAACAGACACACACAATGTTCCAAGTTCCCCTAAAATATGACCCACTTGTT           CTGGGTCTACGCAGAAAAGAGACGCAAAGTGTCCAAAAGGAACAAAAGAACAAAAACGAATAAGCAAA           GAAGAAAACAAACAAAAACAAAACAAAACAAACACACGGACCGATAAACAAAGAAGCGAAGATAAGAA           AGAAGGCCTCATATCCAATTACCTCACTCATTCACATGTGAGCGACACGCAGACATCCGCGAGGGCCA           GCGTCACCAGACCAGCTGCGGGACAAACCACTCAGACTGCTTGTAGGACAAATACTTCTGACATTTTC           GTTTAAGCAAATACAGGTGCATTTAAAACACGACTTTGGGGGTGATTTGTGTGTAGCGCCTGGGGAGG           GGGGATAAAAGAGGAGGAGTGAGCACTGGAAATACTTTTTAAAGAAAAAAAAACATGAGGGAATAAAA           GAAATTCCTATCAAAAATCAAAGTGAAATAATACCATCCAGCACTTAACTCTCAGGTCCCAACTAAGT           CTGGCCTGAGCTAATTTATTTGAGCGCAGAGTGTAAAATTTAATTCAAAATGGTGGCTATAATCACTA           CAGATAAATTTCATACTCTTTTGTCTTTGGAGATTCCATTGTGGACAGTAATACGCAGTTACAGGGTG           TAGTCTGTTTAGATTCCGTAGTTCGTGGGTATCAGTTTCGGTAGAGGTGCAGCATCGTGACACTTTTG           CTAACAGGTACCACTTCTGATCACCCTGTACATACATGAGCCGAAAGGCACAATCACTGTTTCAGATT           TAAAATTATTAGTGTGTTTGTTTGGTCCAGAAACTGAGACAATCACATGACAGTCACCACGAGGAGAG           AAAATTTAAAAAATAAAAATAAAAACAAAAAAAATTTTAAAAATTAAAAAAACAAAAATAAAGTCTAA           TAAGAACTTTGGTACAGGAACTTTTTTGTAATATACATGTATGAATTGTTCATCGAGTTTTTATATTA           ATTTTAATTTGCTGCTAAGCAAAGACTAGGGACAGGCAAAGATAATTTATGGCAAAGTGTTTAAATTG           TTTATACATAAATAAAGTCTCTAAAACTCCTGTG                                                   NOV7s, CG50426-12   SEQ ID NO: 150   2733 aa   MW at 303423.3kD               Protein Sequence                     MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRE           SDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGI       KSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSN       TSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNR       NSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLT       SGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKNSSIDSG       EAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEK       WSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGE       CVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCID       GNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTG       LCSCDPNWNGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECRE       GWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGD       GLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFN       SSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERT       VWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIE       LPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLASTFIWDKT       DAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILHKG       TGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFNYIRRIFPS       RNVTSILELRNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTG       EQCLPFDEARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPL       SCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLA       IHSALESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSGDDAY       ATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAYNQYEAASPGEQELYVFNADGIHQYT       VSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQ       NLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRITNVTRPTGVVTSLHREMEKSITIDIENSNRD       DDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNIS       LPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVG       RPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLL       QSQRQYIFEYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLG       TGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSE       EGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVENFGKFGVTYYDINQIITTAVMT       LSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVN       DRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGL       LTRAYNKASGWSVQYRYDGVGRRASYKTNLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGH       LFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTK       LVHFTQRDYDVLAGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQ       LSNIIPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASIREKA       GHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKDTHYFVKIG       SADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRPFTNIEFQYSTLLLSIRYGLTPDTLDEEKA       RVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSS       NIQFLRQNEMGKR                                             NOV7t, CG50426-13   SEQ ID NO: 151   1605 bp               DNA Sequence   ORF Start: at 405   ORF Stop: at 1605                       AGCTGAGGTAGCCGGCTCTGGCCTCGGCTAGCCCAGAAAGGGGCTCCCACAGTGCAGCAGCGGGCTGA               AGGGCTCCTCAAGCGTGGCCAGAGTGGGCGCTGAGGCCGAGGAGGCACCGAGAGCGAGCGAGGGCTGC           AAGGTCTGCCAGCACGCTGTCACTTCTCACTATTTTGATTGGTATTGTGTCCGGAATTGGTGGGTTCT           TGGTCTCACTGACTTCAAGAATGAAGCCACGGACCCTCGCGTTACATCCAGCTTTTTAATTGCCTAAG           CGGTCTGGGGCTTGCTTCGTCATTTGGCTTTGCTGTGGAGCACTCCTGTAAAGCCAGCTGAATTGTAC           ATCGAAGATCCACCCTTTTGGTGGCAAAGTGACAAGTGCCAAAACTCAGGCCTGACTTTTCTGA AAAC       ATCAGCATTCTGCCATATCTGGAATAATGGATGTAAAGGACCGGCGACACCGCTCTTTGACCAGAGGA       CGCTGTGGCAAAGAGTGTCGCTACACAAGCTCCTCTCTGGACAGTGAGGACTGCCGGGTGCCCACACA       GAAATCCTACAGCTCCAGTGAGACTCTGAAGGCCTATGACCATGACAGCAGGATGCACTATGGAAACC       GAGTCACAGACCTCATCCACCGGGAGTCAGATGAGTTTCCTAGACAAGGAACCAACTTCACCCTTGCC       GAACTGGGCATCTGTGAGCCCTCCCCACACCGAAGCGGCTACTGCTCCGACATGGGGATCCTTCACCA       GGGCTACTCCCTTAGCACAGGGTCTGACGCCGACTCCGACACCGAGGGAGGGATGTCTCCAGAACACG       CCATCAGACTGTGGGGCAGAGGGATAAAATCCAGGCGCAGTTCCGGCCTGTCCAGTCGTGAAAACTCG       GCCCTTACCCTGACTGACTCTGACAACGAAAACAAATCAGATGATGAGAACGGTCGTCCCATTCCACC       TACATCCTCGCCTAGTCTCCTCCCATCTGCTCAGCTGCCTAGCTCCCATAATCCTCCACCAGTTAGCT       GCCAGATGCCATTGCTAGACAGCAACACCTCCCATCAAATCATGGACACCAACCCTGATGAGGAATTC       TCCCCCAATTCATACCTGCTCAGAGCATGCTCAGGGCCCCAGCAAGCCTCCAGCAGTGGCCCTCCGAA       CCACCACAGCCAGTCGACTCTGAGGCCCCCTCTCCCACCCCCTCACAACCACACGCTGTCCCATCACC       ACTCGTCCGCCAACTCCCTCAACAGGAACTCACTGACCAATCGGCGGAGTCAGATCCACGCCCCGGCC       CCAGCGCCCAATGACCTGGCCACCACACCAGAGTCCGTTCAGCTTCAGGACAGCTGGGTGCTAAACAG       CAACGTGCCACTGGAGACCCGGCACTTCCTCTTCAAGACCTCCTCGGGGAGCACACCCTTGTTCAGCA       GCTCTTCCCCGGGATACCCTTTGACCTCAGGAACGGTTTACACGCCCCCGCCCCGCCTGCTGCCCAGG       AATACTTTCTCCAGGAAGGCTTTCAAGCTGAAGAAGCCCTCCAAATACTGCAGCTGGAAATGTGCTGC       CCTCTCCGCCATTGCCGCGGCCCTCCTCTTGGCTATTTTGC                                                 NOV7t, CG50426-13   SEQ ID NO: 152   400 aa   MW at 43764.8kD               Protein Sequence                     KHQHSAISGIMDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYG           NRVTDLIHRESDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPE       HAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPV       SCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSH       HHSSANSLNRNSLTNRRSQIHAPAPAPUDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLF       SSSSPGYPLTSGTVYTPPPRLLPRINTFSPAFKLKKPSKYCSWKCAALSAIAAALLLAIL                                             NOV7u, CG50426-14   SEQ ID NO: 153   9823 bp               DNA Sequence   ORF Start: ATG at 277   ORF Stop: TAA at 8476                       GCTCCAAAGCGAGCTGGGACCGAAGACTCTAGGCTAAGTTATCTATGTAGATGGTGTCAGGGAGCGAA               GCTACTGACCGAGCTGCTGTTACATCCAGCTTTTTAATTGCCTAAGCGGTCTGGGGCTTGCTTCGTCA           TTTGGCTTTGCTGTGGAGCACTCCTGTAAAGCCAGCTGAATTGTACATCGAAGATCCACCCTTTTGGT           GGCAAAGTGACAAGTGCCAAAACTCAGGCCTGACTTTTCTGAAAACATCAGCATTCTGCCATATCTGG           AATA   ATG GATGTAAAGGACCGGCGACACCGCTCTTTGACCAGAGGACGCTGTGGCAAAGAGTGTCGCT       ACACAAGCTCCTCTCTGGACAGTGAGGACTGCCGGGTGCCCACACAGAAATCCTACAGCTCCAGTGAG       ACTCTGAAGGCCTATGACCATGACAGCAGGATGCACTATGGAAACCGAGTCACAGACCTCATCCACCG       GGAGTCAGATGAGTTTCCTAGACAAGGAACCAACTTCACCCTTGCCGAACTGGGCATCTGTGAGCCCT       CCCCACACCGAAGCGGCTACTGCTCCGACATGGGGATCCTTCACCAGGGCTACTCCCTTAGCACAGGG       TCTGACGCCGACTCCGACACCGAGGGAGGGATGTCTCCAGAACACGCCATCAGACTGTGGGGCAGAGG       GATAAAATCCAGGCGCAGTTCCGGCCTGTCCAGTCGTGAAAACTCGGCCCTTACCCTGACTGACTCTG       ACAACGAAAACAAATCAGATGATGAGAACGGTCGTCCCATTCCACCTACATCCTCGCCTAGTCTCCTC       CCATCTGCTCAGCTGCCTAGCTCCCATAATCCTCCACCAGTTAGCTGCCAGATGCCATTGCTAGACAG       CAACACCTCCCATCAAATCATGGACACCAACCCTGATGAGGAATTCTCCCCCAATTCATACCTGCTCA       GAGCATGCTCAGGGCCCCAGCAAGCCTCCAGCAGTGGCCCTCCGAACCACCACAGCCAGTCGACTCTG       AGGCCCCCTCTCCCACCCCCTCACAACCACACGCTGTCCCATCACCACTCGTCCGCCAACTCCCTCAA       CAGGAACTCACTGACCAATCGGCGGAGTCAGATCCACGCCCCGGCCCCAGCGCCCAATGACCTGGCCA       CCACACCAGAGTCCGTTCAGCTTCAGGACAGCTGGGTGCTAAACAGCAACGTGCCACTGGAGACCCGG       CACTTCCTCTTCAAGACCTCCTCGGGGAGCACACCCTTGTTCAGCAGCTCTTCCCCGGGATACCCTTT       GACCTCAGGAACGGTTTACACGCCCCCGCCCCGCCTGCTGCCCAGGAATACTTTCTCCAGGAAGGCTT       TCAAGCTGAAGAAGCCCTCCAAATACTGCAGCTGGAAATGTGCTGCCCTCTCCGCCATTGCCGCGGCC       CTCCTCTTGGCTATTTTGCTGGCGTATTTCATAGTGCCCTGGTCGTTGAAAAACAGCAGCATAGACAG       TGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGGGGTGTTTTGGAGGTCACAAA       TTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGAAGGACGCTCTCTTTGGTGTT       TACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTATGACTTCATGGAACGTCTGGACGGGAAGGA       GAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGACCTTGGTTCAGAATGAAGCCG       TGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACAATGATGGAAAAGACAAAGAG       ATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCAGGACTGTCCACGTAACTGCCATGGGAATGG       TGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGCAGACTGTGCTAAAGCTGCCT       GCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAAGGGACGTGCCAGTGCTACAGCGGCTGGAAA       GGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGATCCTTCCTGCGGGGGCCACGGCTCCTGCAT       TGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCGAGCACTGTGAGGAAGTTGATTGCTTGGATC       CCACCTGCTCCAGCCACGGAGTCTGTGTGAATGGAGAATGCCTGTGCAGCCCTGGCTGGGGTGGTCTG       AACTGTGAGCTGGCGAGGGTCCAGTGCCCAGACCAGTGCAGTGGGCATGGCACGTACCTGCCTGACAC       GGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCGACTGCTCTGTTGAAGTGTGCTCAGTAGACT       GTGGCACTCACGGCGTCTGCATCGGGGGAGCCTGCCGCTGTGAAGAGGGCTGGACAGGCGCAGCGTGT       GACCAGCGCGTGTGCCACCCCCGCTGCATTGAGCACGGGACCTGTAAAGATGGCAAATGTGAATGCCG       AGAGGGCTGGAATGGTGAACACTGCACCATTGGTAGGCAAACGGCAGGCACCGAAACAGATGGCTGCC       CTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGTCAGAACAGCTGGCAGTGTGTCTGCCAGACC       GGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAACTTCCTGTGCTGATAACAAGGATAATGAGGG       AGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCCTGCAGTCAGCCTGTCAGAACAGCCTGCTCT       GCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAGGGCCAGACGGATTGGCCCGCAGTGAAGTCC       TTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAGCACCCACATCATTCCTGGAGAGAACCCTTT       CAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAGTAACTACAGATGGAACTCCCCTGGTCGGTG       TGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTACACCATCACCCGCCAGGATGGCACGTTCGAC       CTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTTTGAGCGAGCCCCGTTCATGAGCCAGGAGCG       CACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGGACACCCTGGTGATGAAGACCGAGGAGAACT       CCATCCCCAGCTGTGACCTCAGTGGCTTTGTCCGGCCTGATCCAATCATCATCTCCTCCCCACTGTCC       ACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGTGCCTGAGACCCAGGTTCTTCATGAAGAAAT       CGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGAGCTCTAGAACTGCAGGGTACAAGTCACTGC       TGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAACCTCATTAGGGTTCACCTGATGGTGGCTGTC       GAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCCCAACCTGGCCTCCACCTTCATCTGGGACAA       GACAGATGCGTATGGCCAAAGGGTGTATGGACTCTCAGATGCTGTTGTGTCTGTCGGGTTTGAATATG       AGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACAGCCCTCCTTCAGGGATTCGAGCTGGACCCC       TCCAACCTCGGTGGCTGGTCCCTAGACAAACACCACATCCTCAATGTTAAAAGTGGAATCCTACACAA       AGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTGCCATCATCACCAGCATCATGGGCAATGGTC       GCCGCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTTGCTGAAGGCAACAAGCTGCTGGCCCCAGTG       GCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGGTGACTTCAATTACATCCGACGCATCTTTCC       CTCTCGAAATGTGACCAGCATCTTGGAGTTACGAAATAAAGAGTTTAAACATAGCAACAACCCAGCAC       ACAAGTACTACTTGGCAGTGGACCCCGTGTCCGGCTCGCTCTACGTGTCCGACACCAACAGCAGGAGA       ATCTACCGCGTCAAGTCTCTGAGTGGAACCAAAGACCTGGCTGGGAATTCGGAAGTTGTGGCAGGGAC       GGGAGAGCAGTGTCTACCCTTTGATGAAGCCCGCTGCGGGGATGGAGGGAAGGCCATAGATGCAACCC       TGATGAGCCCGAGAGGTATTGCAGTAGACAAGAATGGGCTCATGTACTTTGTCGATGCCACCATGATC       CGGAAGGTTGACCAGAATGGAATCATCTCCACCCTGCTGGGCTCCAATGACCTCACTGCCGTCCGGCC       GCTGAGCTGTGATTCCAGCATGGATGTAGCCCAGGTTCGTCTGGAGTGGCCAACAGACCTTGCTGTCA       ATCCCATGGATAACTCCTTGTATGTTCTAGAGAACAATGTCATCCTTCGAATCACCGAGAACCACCAA       GTCAGCATCATTGCGGGACGCCCCATGCACTGCCAAGTTCCTGGCATTGACTACTCACTCAGCAAACT       AGCCATTCACTCTGCCCTGGAGTCAGCCAGTGCCATTGCCATTTCTCACACTGGGGTCCTCTACATCA       CTGAGACAGATGAGAAGAAGATTAACCGTCTACGCCAGGTAACAACCAACGGGGAGATCTGCCTTTTA       GCTGGGGCAGCCTCGGACTGCGACTGCAAAAACGATGTCAATTGCAACTGCTATTCAGGAGATGATGC       CTACGCGACTGATGCCATCTTGAATTCCCCATCATCCTTAGCTGTAGCTCCAGATGGTACCATTTACA       TTGCAGACCTTGGAAATATTCGGATCAGGGCGGTCAGCAAGAACAAGCCTGTTCTTAATGCCTTCAAC       CAGTATGAGGCTGCATCCCCCGGAGAGCAGGAGTTATATGTTTTCAACGCTGATGGCATCCACCAATA       CACTGTGAGCCTGGTGACAGGGGAGTACTTGTACAATTTCACATATAGTACTGACAATGATGTCACTG       AATTGATTGACAATAATGGGAATTCCCTGAAGATCCGTCGGGACAGCAGTGGCATGCCCCGTCACCTG       CTCATGCCTGACAACCAGATCATCACCCTCACCGTGGGCACCAATGGAGGCCTCAAAGTCGTGTCCAC       ACAGAACCTGGAGCTTGGTCTCATGACCTATGATGGCAACACTGGGCTCCTGGCCACCAAGAGCGATG       AAACAGGATGGACGACTTTCTATGACTATGACCACGAAGGCCGCCTGACCAACGTGACGCGCCCCACG       GGGGTGGTAACCAGTCTGCACCGGGAAATGGAGAAATCTATTACCATTGACATTGAGAACTCCAACCG       TGATGATGACGTCACTGTCATCACCAACCTCTCTTCAGTAGAGGCCTCCTACACAGTGGTACAAGATC       AAGTTCGGAACAGCTACCAGCTCTGTAATAATGGTACCCTGAGGGTGATGTATGCTAATGGGATGGGT       ATCAGCTTCCACAGCGAGCCCCATGTCCTAGCGGGCACCATCACCCCCACCATTGGACGCTGCAACAT       CTCCCTGCCTATGGAGAATGGCTTAAACTCCATTGAGTGGCGCCTAAGAAAGGAACAGATTAAAGGCA       AAGTCACCATCTTTGGCAGGAAGCTCCGGGTCCATGGAAGAAATCTCTTGTCCATTGACTATGATCGA       AATATTCGGACTGAAAAGATCTATGATGACCACCGGAAGTTCACCCTGAGGATCATTTATGACCAGGT       GGGCCGCCCCTTCCTCTGGCTGCCCAGCAGCGGGCTGGCAGCTGTCAACGTGTCATACTTCTTCAATG       GGCGCCTGGCTGGGCTTCAGCGTGGGGCCATGAGCGAGAGGACAGACATCGACAAGCAAGGCCGCATC       GTGTCCCGCATGTTCGCTGACGGGAAAGTGTGGAGCTACTCCTACCTTGACAAGTCCATGGTCCTCCT       GCTTCAGAGCCAACGTCAGTATATATTTGAGTATGACTCCTCTGACCGCCTCCTTGCCGTCACCATGC       CCAGCGTGGCCCGGCACAGCATGTCCACACACACCTCCATCGGCTACATCCGTAATATTTACAACCCG       CCTGAAAGCAATGCTTCGGTCATCTTTGACTACAGTGATGACGGCCGCATCCTGAAGACCTCCTTTTT       GGGCACCGGACGCCAGGTGTTCTACAAGTATGGGAAACTCTCCAAGTTATCAGAGATTGTCTACGACA       GTACCGCCGTCACCTTCGGGTATGACGAGACCACTGGTGTCTTGAAGATGGTCAACCTCCAAAGTGGG       GGCTTCTCCTGCACCATCAGGTACCGGAAGATTGGCCCCCTGGTGGACAAGCAGATCTACAGGTTCTC       CGAGGAAGGCATGGTCAATGCCAGGTTTGACTACACCTATCATGACAACAGCTTCCGCATCGCAAGCA       TCAAGCCCGTCATAAGTGAGACTCCCCTCCCCGTTGACCTCTACCGCTATGATGAGATTTCTGGCAAG       GTGGAACACTTTGGTAAGTTTGGAGTCATCTATTATGACATCAACCAGATCATCACCACTGCCGTGAT       GACCCTCAGCAAACACTTCGACACCCATGGGCGGATCAAGGAGGTCCAGTATGAGATGTTCCGGTCCC       TCATGTACTGGATGACGGTGCAATATGACAGCATGGGCAGGGTGATCAAGAGGGAGCTAAAACTGGGG       CCCTATGCCAATACCACGAAGTACACCTATGACTACGATGGGGACGGGCAGCTCCAGAGCGTGGCCGT       CAATGACCGCCCGACCTGGCGCTACAGCTATGACCTTAATGGGAATCTCCACTTACTGAACCCAGGCA       ACAGTGTGCGCCTCATGCCCTTGCGCTATGACCTCCGGGATCGGATAACCAGACTCGGGGATGTGCAG       TACAAAATTGACGACGATGGCTATCTGTGCCAGAGAGGGTCTGACATCTTCGAATACAATTCCAAGGG       CCTCCTAACAAGAGCCTACAACAAGGCCAGCGGGTGGAGTGTCCAGTACCGCTATGATGGCGTAGGAC       GGCGGGCTTCCTACAAGACCAACCTGGGCCACCACCTGCAGTACTTCTACTCTGACCTCCACAACCCG       ACGCGCATCACCCATGTCTACAATCACTCCAACTCGGAGATTACCTCACTGTACTACGACCTCCAGGG       CCACCTCTTTGCCATGGAGAGCAGCAGTGGGGAGGAGTACTATGTTGCCTCTGATAACACAGGGACTC       CTCTGGCTGTGTTCAGCATCAACGGCCTCATGATCAAACAGCTGCAGTACACGGCCTATGGGGAGATT       TATTATGACTCCAACCCCGACTTCCAGATGGTCATTGGCTTCCATGGGGGACTCTATGACCCCCTGAC       CAAGCTGGTCCACTTCACTCAGCGTGATTATGATGTGCTGGCAGGACGATGGACCTCCCCAGACTATA       CCATGTGGAAAAACGTGGGCAAGGAGCCGGCCCCCTTTAACCTGTATATGTTCAAGAGCAACAATCCT       CTCAGCAGTGAGCTAGATTTGAAGAACTACGTGACAGATGTGAAAAGCTGGCTTGTGATGTTTGGATT       TCAGCTTAGCAACATCATTCCTGGCTTCCCGAGAGCCAAAATGTATTTCGTGCCTCCTCCCTATGAAT       TGTCAGAGAGTCAAGCAAGTGAGAATGGACAGCTCATTACAGGTGTCCAACAGACAACAGAGAGACAT       AACCAGGCCTTCATGGCTCTGGAAGGACAGGTCATTACTAAAAAGCTCCACGCCAGCATCCGAGAGAA       AGCAGGTCACTGGTTTGCCACCACCACGCCCATCATTGGCAAAGGCATCATGTTTGCCATCAAAGAAG       GGCGGGTGACCACGGGCGTGTCCAGCATCGCCAGCGAAGATAGCCGCAAGGTGGCATCTGTGCTGAAC       AACGCCTACTACCTGGACAAGATGCACTACAGCATCGAGGGCAAGGACACCCACTACTTTGTGAAGAT       TGGCTCAGCCGATGGCGACCTGGTCACACTAGGCACCACCATCGGCCGCAAGGTGCTAGAGAGCGGGG       TGAACGTGACCGTGTCCCAGCCCACGCTGCTGGTCAACGGCAGGACTCGAAGGTTCACGAACATTGAG       TTCCAGTACTCCACGCTGCTGCTCAGCATCCGCTATGGCCTCACCCCCGACACCCTGGACGAAGAGAA       GGCCCGCGTCCTGGACCAGGCGAGACAGAGGGCCCTGGGCACGGCCTGGGCCAAGGAGCAGCAGAAAG       CCAGGGACGGGAGAGAGGGGAGCCGCCTGTGGACTGAGGGCGAGAAGCAGCAGCTTCTGAGCACCGGG       CGCGTGCAAGGGTACGAGGGATATTACGTGCTTCCCGTGGAGCAATACCCAGAGCTTGCAGACAGTAG       CAGCAACATCCAGTTTTTAAGACAGAATGAGATGGGAAAGAGG TAA   CAAAATAATCTGCTGCCATTCC           TTGTCTGAATGGCTCAGCAGGAGTAACTGTTATCTCCTCTCCTAAGGAGATGAAGACCTAACAGGGGC           ACTGCGGCTGGGCTGCTTTAGGAGACCAAGTGGCAAGAAAGCTCACATTTTTTGAGTTCAAATGCTAC           TGTCCAAGCGAGAAGTCCCTCATCCTGAAGTAGACTAAAGCCCGGCTGAAAATTCCGAGGAAAACAAA           ACAAACGAATGAATGAACAGACACACACAATGTTCCAAGTTCCCCTAAAATATGACCCACTTGTTCTG           GGTCTACGCAGAAAAGAGACGCAAAGTGTCCAAAAGGAACAAAAGAACAAAAACGAATAAGCAAAGAA           GAAAACAAACAAAAACAAAACAAAACAAACACACGGACCGATAAACAAAGAAGCGAAGATAAGAAAGA           AGGCCTCATATCCAATTACCTCACTCATTCACATGTGAGCGACACGCAGACATCCGCGAGGGCCAGCG           TCACCAGACCAGCTGCGGGACAAACCACTCAGACTGCTTGTAGGACAAATACTTCTGACATTTTCGTT           TAAGCAAATACAGGTGCATTTAAAACACGACTTTGGGGGTGATTTGTGTGTAGCGCCTGGGGAGGGGG           GATAAAAGAGGAGGAGTGAGCACTGGAAATACTTTTTAAAGAAAAAAAAACATGAGGGAATAAAAGAA           ATTCCTATCAAAAATCAAAGTGAAATAATACCATCCAGCACTTAACTCTCAGGTCCCAACTAAGTCTC           GCCTGAGCTAATTTATTTGAGCGCAGAGTGTAAAATTTAATTCAAAATGGTGGCTATAATCACTACAG           ATAAATTTCATACTCTTTTGTCTTTGGAGATTCCATTGTGGACAGTAATACGCAGTTACAGGGTGTAG           TCTGTTTAGATTCCGTAGTTCGTGGGTATCAGTTTCGGTAGAGGTGCAGCATCGTGACACTTTTGCTA           ACAGGTACCACTTCTGATCACCCTGTACATACATGAGCCGAAAGGCACAATCACTGTTTCAGATTTAA           AATTATTAGTGTGTTTGTTTGGTCCAGAAACTGAGACAATCACATGACAGTCACCACGAGGAGAGAAA           ATTTAAAAAATAAAAATAAAAACAAAAAAAATTTTAAAAATTAAAAAAACAAAAATAAAGTCTAATAA           GAACTTTGGTACAGGAACTTTTTTGTAATATACATGTATGAATTGTTCATCGAGTTTTTATATTAATT           TTAATTTGCTGCTAAGCAAAGACTAGGGACAGGCAAAGATAATTTATGGCAAAGTGTTTAAATTGTTT           ATACATAAATAAAGTCTCTAAAACTCCTGTG                                                   NOV7u, CG50426-14   SEQ ID NO: 154   2733 aa   MW at 303423.3kD               Protein Sequence                     MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRE           SDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGI       KSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSN       TSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNR       NSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLT       SGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKNSSIDSG       EAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEK       WSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGE       CVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCID       GNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTG       LCSCDPNWNGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECRE       GWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGD       GLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFN       SSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERT       VWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIE       LPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLASTFIWDKT       DAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILHKG       TGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFNYIRRIFPS       RNVTSILELRNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTG       EQCLPFDEARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPL       SCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLA       IHSALESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSGDDAY       ATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAYNQYEAASPGEQELYVFNADGIHQYT       VSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQ       NLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRITNVTRPTGVVTSLHREMEKSITIDIENSNRD       DDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNIS       LPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVG       RPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLL       QSQRQYIFEYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLG       TGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSE       EGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVENFGKFGVTYYDINQIITTAVMT       LSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVN       DRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGL       LTRAYNKASGWSVQYRYDGVGRRASYKTNLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGH       LFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTK       LVHFTQRDYDVLAGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQ       LSNIIPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASIREKA       GHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKDTHYFVKIG       SADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRPFTNIEFQYSTLLLSIRYGLTPDTLDEEKA       RVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSS       NIQFLRQNEMGKR                                             NOV7v, CG50426-16   SEQ ID NO: 155   2478 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     AAAAACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGG           GGTGTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGA       AGGACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTATGACTTCATG       GAACGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGAC       CTTGGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACA       ATGATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCAGGACTGTCCA       CGTAACTGCCATGGGAATGGTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGC       AGACTGTGCTAAAGCTGCCTGCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAAGGGACGTGCC       AGTGCTACAGCGGCTGGAAAGGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGATCCTTCCTGC       GGGGGCCACGGCTCCTGCATTGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCGAGCACTGTGA       GGAAGTTGATTGCTTGGATCCCACCTGCTCCAGCCACGGAGTCTGTGTGAATGGAGAATGCCTGTGCA       GCCCTGGCTGGGGTGGTCTGAACTGTGAGCTGGCGAGGGTCCAGTGCCCAGACCAGTGCAGTGGGCAT       GGCACGTACCTGCCTGACACGGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCGACTGCTCTGT       TGAAGTGTGCTCAGTAGACTGTGGCACTCACGGCGTCTGCATCGGGGGAGCCTGCCGCTGTGAAGAGG       GCTGGACAGGCGCAGCGTGTGACCAGCGCGTGTGCCACCCCCGCTGCATTGAGCATGGGACCTGTAAA       GATGGCAAATGTGAATGCCGAGAGGGCTGGAATGGTGAACACTGCACCATTGGTAGGCAAACGGCAGG       CACCGAAACAGATGGCTGCCCTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGTCAGAACAGCT       GGCAGTGTGTCTGCCAGACCGGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAACTTCCTGTGCT       GATAACAAGGATAATGAGGGAGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCCTGCAGTCAGC       CTGTCAGAACAGCCTGCTCTGCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAGGGCCAGACGG       ATTGGCCCGCAGTGAAGTCCTTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAGCACCCACATC       ATTCCTGGAGAGAACCCTTTCAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAGTAACTACAGA       TGGAACTCCCCTGGTCGGTGTGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTACACCATCACCC       GCCAGGATGGCACGTTCGACCTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTTTGAGCGAGCC       CCGTTCATGAGCCAGGAGCGCACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGGACACCCTGGT       GATGAAGACCGAGGAGAACTCCATCCCCAGCTGTGACCTCAGTGGCTTTGTCCGGCCTGATCCAATCA       TCATCTCCTCCCCACTGTCCACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGTGCCTGAGACC       CAGGTTCTTCATGAAGAAATCGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGAGCTCTAGAAC       TGCAGGGTACAAGTCACTGCTGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAACCTCATTAGGG       TTCACCTGATGGTGGCTGTCGAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCCCAACCTGGCC       TACACCTTCATCTGGGACAAGACAGATGCGTATGGCCAAAGGGTGTATGGACTCTCAGATGCTGTTGT       GTCTGTCGGGTTTGAATATGAGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACAGCCCTCCTTC       AGGGATTCGAGCTGGACCCCTCCAACCTCGGTGGCTGGTCCCTAGACAAACACCACATCCTCAATGTT       AAAAGTGGAATCCTACACAAAGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTGCCATCATCAC       CAGCATCATGGGCAATGGTCGTCGCCGGAGCATTTCTTGTCCCAGCTGCAACGGCCTCGCTGAAGGCA       ACAAGCTGCTGGCCCCAGTGGCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGGTGACTTCAAT       TACATCCGACGCATCTTTCCCTCTCGAAAT                                                 NOV7v, CG50426-16   SEQ ID NO: 156   826 aa   MW at 89909.7kD               Protein Sequence                     KNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFM           ERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCP       RNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPNNQCIDPSC       GGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGH       GTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCK       DGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCA       DNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHI       IPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERA       PFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPET       QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLA       YTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNV       KSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFN       YIRRIFPSRN                                             NOV7w, CG50426-18   SEQ ID NO: 157   57 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GACACGGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCGACTGCTCTGTTGAA                                                     NOV7w, CG50426-18   SEQ ID NO: 158   19 aa   MW at 2029.2kD               Protein Sequence                     DTGLCSCDPNWMGPDCSVE                                                 NOV7x, CG50426-19   SEQ ID NO: 159   54 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GACCGTATCAAGCTCTTGGCAGGCAAGGATAGCACCCACATCATTCCTGGAGAG                                                     NOV7x, CG50426-19   SEQ ID NO: 160   18 aa   MW at 1963.2kD               Protein Sequence                     DRIKLLAGKDSTHIIPGE                                                 NOV7y, CG50426-20   SEQ ID NO: 161   60 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     TCTGCTGGCTACAAAGGCGAGCACTGTGAGGAAGTTGATTGCTTGGATCCCACCTGCTCC                                                     NOV7y, CG50426-20   SEQ ID NO: 162   20 aa   MW at 2143.3kD               Protein Sequence                     SAGYKGEHCEEVDCLDPTCS                                                 NOV7z, CG50426-22   SEQ ID NO: 163   540 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     AACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGGGGT           GTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGAAGG       ACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTATGACTTCATGGAA       CGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGACCTT       GGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACAATG       ATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTGTTGTCCTAGATGATTCAGTGCAGGACTGTCCA       CGTAACTGCCATGGGAATGGTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGC       AGACTGTGCTAAAGACCTTCCTGCCTTGACTTTCTGCAAGACAATCATTAATAAAGCTGCTCTG                                                 NOV7z, CG50426-22   SEQ ID NO: 164   180 aa   MW at 20167.7kD               Protein Sequence                     NSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFME           RLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKENVSFNTVVLDDSVQDCP       RNCHGNGECVSGVCHCFPGFLGADCAKDLPALTFCKTIINKAAL                                             NOV7aa, CG50426-23   SEQ ID NO: 165   2497 bp               DNA Sequence   ORF Start: at 11   ORF Stop: at 2489                       CACCAAGCTT AAAAACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAG           TCCCACCAGGGGTGTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATC       TCCCTCGGGAAGGACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTA       TGACTTCATGGAACGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGA       GCATACAGACCTTGGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTG       GCCTTCTACAATGATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCA       GGACTGTCCACGTAACTGCCATGGGAATGGTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGAT       TTCTAGGAGCAGACTGTGCTAAAGCTGCCTGCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAA       GGGACGTGCCAGTGCTACAGCGGCTGGAAAGGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGA       TCCTTCCTGCGGGGGCCACGGCTCCTGCATTGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCG       AGCACTGTGAGGAAGTTGATTGCTTGGATCCCACCTGCTCCAGCCACGGAGTCTGTGTGAATGGAGAA       TGCCTGTGCAGCCCTGGCTGGGGTGGTCTGAACTGTGAGCTGGCGAGGGTCCAGTGCCCAGACCAGTG       CAGTGGGCATGGCACGTACCTGCCTGACACGGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCG       ACTGCTCTGTTGAAGTGTGCTCAGTAGACTGTGGCACTCACGGCGTCTGCATCGGGGGAGCCTGCCGC       TGTGAAGAGGGCTGGACAGGCGCAGCGTGTGACCAGCGCGTGTGCCACCCCCGCTGCATTGAGCACGG       GACCTGTAAAGATGGCAAATGTGAATGCCGAGAGGGCTGGAATGGTGAACACTGCACCATTGGTAGGC       AAACGGCAGGCACCGAAACAGATGGCTGCCCTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGT       CAGAACAGCTGGCAGTGTGTCTGCCAGACCGGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAAC       TTCCTGTGCTGATAACAAGGATAATGAGGGAGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCC       TGCAGTCAGCCTGTCAGAACAGCCTGCTCTGCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAG       GGCCAGACGGATTGGCCCGCAGTGAAGTCCTTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAG       CACCCACATCATTCCTGGAGAGAACCCTTTCAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAG       TAACTACAGATGGAACTCCCCTGGTCGGTGTGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTAC       ACCATCACCCGCCAGGATGGCACGTTCGACCTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTT       TGAGCGAGCCCCGTTCATGAGCCAGGAGCGCACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGG       ACACCCTGGTGATGAAGACCGAGGAGAACTCCATCCCCAGCTGTGACCTCAGTGGCTTTGTCCGGCCT       GATCCAATCATCATCTCCTCCCCACTGTCCACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGT       GCCTGAGACCCAGGTTCTTCATGAAGAAATCGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGA       GCTCTAGAACTGCAGGGTACAAGTCACTGCTGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAAC       CTCATTAGGGTTCACCTGATGGTGGCTGTCGAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCC       CAACCTGGCCTACACCTTCATCTGGGACAAGACAGATGCGTATGGCCAAAGGGTGTATGGACTCTCAG       ATGCTGTTGTGTCTGTCGGGTTTGAATATGAGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACA       GCCCTCCTTCAGGGATTCGAGCTGGACCCCTCCAACCTCGGTGGCTGGTCCCTAGACAAACACCACAT       CCTCAATGTTAAAAGTGGAATCCTACACAAAGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTG       CCATCATCACCAGCATCATGGGCAATGGTCGCCGCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTT       GCTGAAGGCAACAAGCTGCTGGCCCCAGTGGCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGG       TGACTTCAATTACATCCGACGCATCTTTCCCTCTCGAAATCTCGAGGGC                                                 NOV7aa, CG50426-23   SEQ ID NO: 166   826 aa   MW at 89909.7kD               Protein Sequence                     KNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFM           ERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCP       RNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPNNQCIDPSC       GGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGH       GTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCK       DGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCA       DNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHI       IPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERA       PFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPET       QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLA       YTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNV       KSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFN       YIRRIFPSRN                                             NOV7ab, CG50426-24   SEQ ID NO: 167   8575 bp               DNA Sequence   ORF Start: ATG at 199   ORF Stop: TAA at 8476                       TAAAGTACCTGTCATCTTGACAAGTGGCGGAGCGGAGGAGTCAAGGATTATAAATGATCACAGCCAGG               TCCAGCTCGCCCCGTGATTGGGCTCTCCCGCGATCTGCACCGGGGGAAGCGCATGAGAGGCCAATGAG           ACTTGAACCCTGAGCCTAAGTTGTCACCAGCAGGACTGATGTGCACACAGAAGGAATGAAGT   ATG GAT       GTGAAAGAACGCAGGCCTTACTGCTCCCTGACCAAGAGCAGACGAGAGAAGGAACGGCGCTACACAAA       TTCCTCCGCAGACAATGAGGAGTGCCGGGTACCCACACAGAAGTCCTACAGTTCCAGCGAGACATTGA       AAGCTTTTGATCATGATTCCTCGCGGCTGCTTTACGGCAACAGAGTGAAGGATTTGGTTCACAGAGAA       GCAGACGAGTTCACTAGACAAAGCAGGATGCACTATGGAAACCGAGTCACAGACCTCATCCACCGGGA       GTCAGATGAGTTTCCTAGACAAGGTATCCTTCACCAGGGCTACTCCCTTAGCACAGGGTCTGACGCCG       ACTCCGACACCGAGGGAGGGATGTCTCCAGAACACGCCATCAGACTGTGGGGCAGAGGGATAAAATCC       AGGCGCAGTTCCGGCCTGTCCAGTCGTGAAAACTCGGCCCTTACCCTGACTGACTCTGACAACGAAAA       CAAATCAGATGATGAGAACGGTCGTCCCATTCCACGTACATCCTCGCGTAGTCTCCTCCCATTTGTTC       AGCTGCCTAGCTCCCATAATCCTCCACCAGTTAGCTGCCAGATGCCATTGCTAGACAGCAACACCTCC       CATCAAATCATGGACACCAACCCTGATGAGGAATTCTCCCCCAATTCATACCTGCTCAGAGCATGCTC       AGGGCCCCAGCAAGCCTCCAGCAGTGGTCCTCCGAACCACCACAGCCAGTCGACTCTGAGGCCCCCTC       TCCCACCCCCTCACAACCACACGCTGTCCCATCACCACTCGTCCGCCAACTCCCTCAACAGGAACTCA       CTGACCAATCGGCGGAGTCAGATCCACGCCCCGGCCCCAGCGCCCAATGACCTGGCCACCACACCAGA       GTCCGTTCAGCTTCAGGACAGCTGGGTGCTAAACAGCAACGTGCCACTGGAGACCCGGCACTTCCTCT       TCAAGACCTCCTCGGGGAGCACACCCTTGTTCAGCAGCTCTTCCCCGGGATACCCTTTGACCTCAGGA       ACGGTTTACACGCCCCCGCCCCGCCTGCTGCCCAGGAATACTTTCTCCAGGAAGGCTTTCAAGCTGAA       GAAGCCCTCCAAATACTGCAGCTGGAAATGTGCTGCCCTCTCCGCCATTGCCGCGGCCCTCCTCTTGG       CTATTTTGCTGGCGTATTTCGCAGCAATGCATCTGCTCGGACTCAATTGGCAACTCCAGCCTGCAGAT       GGGCACACCTTTAACAATGGGATAAGGACCGGCTTACCAGGAAACGATGATGTGGCAACAATGCCATC       TGGAGGCAAAGTGCCCTGGTCGTTGAAAAACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGTCGGC       GGGTAACACAAGAAGTCCCACCAGGGGTGTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCAGTTC       TTAAAGTTCAACATCTCCCTCGGGAAGGACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTCCACC       ATCTCATGCCCAGTATGACTTCATGGAACGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAGTCTC       CCAGGGAACGCCGGAGCATACAGACCTTGGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGATGTG       GGCCTGTGGCATCTGGCCTTCTACAATGATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTGTTGT       CCTAGATTCAGTGCAGGACTGTCCACGTAACTGCCATGGGAATGGTGAATGTGTGTCCGGGGTGTGTC       ACTGTTTCCCAGGATTTCTAGGAGCAGACTGTGCTAAAGCTGCCTGCCCTGTCCTGTGCAGTGGGAAT       GGACAATATTCTAAAGGGACGTGCCAGTGCTACAGCGGCTGGAAAGGTGCAGAGTGCGACGTGCCCAT       GAATCAGTGCATCGATCCTTCCTGCGGGGGCCACGGCTCCTGCATTGATGGGAACTGTGTCTGCTCTG       CTGGCTACAAAGGCGAGCACTGTGAGGAAGTTGATTGCTTGGATCCCACCTGCTCCAGCCACGGAGTC       TGTGTGAATGGAGAATGCCTGTGCAGCCCTGGCTGGGGTGGTCTGAACTGTGAGCTGGCGAGGGTCCA       GTGCCCAGACCAGTGCAGTGGGCATGGCACGTACCTGCCTGACACGGGCCTCTGCAGCTGCGATCCCA       ACTGGATGGGTCCCGACTGCTCTGTTGTGTGCTCAGTAGACTGTGGCACTCACGGCGTCTGCATCGGG       GGAGCCTGCCGCTGTGAAGAGGGCTGGACAGGCGCAGCGTGTGACCAGCGCGTGTGCCACCCCCGCTG       CATTGAGCACGGGACCTGTAAAGATGGCAAATGTGAATGCCGAGAGGGCTGGAATGGTGAACACTGCA       CCATTGATGGCTGCCCTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGTCAGAACAGCTGGCAG       TGTGTCTGCCAGACCGGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAACTTCCTGTGCTGATAA       CAAGGATAATGAGGGAGATGGACTCATTGACTGCATGGATCCCGATTGCTGCCTACAGAGTTCCTGCC       AGAATCAGCCCTATTGTCGGGGACTGCCGGATCCTCAGGACATCATTAGCCAAAGCCTTCAATCGCCT       TCTCAGCAAGCTGCCAAATCCTTTTATGATCGAATCAGTTTCCTTATAGGATCTGATAGCACCCATGT       TATACCTGGAGAAAGTCCTTTCAATAGCTTGGTTTCTCTCATCCGAGGCCAAGTAGTAACTACAGATG       GAACTCCCCTGGTCGGTGTGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTACACCATCACCCGC       CAGGATGGCACGTACTCCCTCTCCAGGTTCGACCTGATCGCAAATGGAGGTGCTTCCTTGACTCTACA       CTTTGAGCGAGCCCCGTTCATGAGCCAGGAGCGCACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCA       TGGACACCCTGGTGATGAAGACCGAGGAGAACTCCATCCCCAGTTGTGACCTCAGTGGTTTTTGTCGG       CTTGATCCCATCATCATCTCCTCCCCTCTGTCCACTTTCTTTAGTGCTGCCCCTGGGCAGAATCCCAT       CGTGCCTGAGACCCAGGTACTTCATGAAGAAATCGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATC       TGAGCTCTAGAACTGCAGGGTACAAGTCACTGCTGAAGATCACCATGACCCAGTCCACAGTGCCCCTG       AACCTCATTAGGGTTCACCTGATGGTGGCTGTCGAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTC       TCCCAACCTGGCCTACACCTTCATCTGGGACAAGACAGATGCGTATGGCCAAAGGGTGTATGGACTCT       CAGATGCTGTTGGTATGTTTTGGTTTCAAAGGACAGCCCTCCTTCAGGGATTCGAGCTGGACCCCTCC       AACCTCGGTGGCTGGTCCCTAGACAAACACCACATCCTCAATGTTAAAAGTGGTATCCTACACAAAGG       CACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTGCCATCATCACCAGCATCATGGGCAATGGTCGCC       GCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTTGCTGAAGGCAACAAGCTGCTGGCCCCAGTGGCT       CTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGGTGACTTCAATTACATCCGACGCATCTTTCCCTC       TCGAAATGTGACCAGCATCTTGGAGTTACGGAGAAATAAAGAGTTTAAACATAGCAACAACCCAGCAC       ACAAGTACTACTTGGCAGTGGACCCCGTGTCCGGCTCGCTCTACGTGTCCGACACCAACAGCAGGAGA       ATCTACCGCGTCAAGTCTCTGAGTGGAACCAAAGACCTGGCTGGGAATTCGGAAGTTGTGGCAGGGAC       GGGAGAGCAGTGTCTACCCTTTGATGAAGCCCGCTGCGGGGATGGAGGGAAGGCCATAGATGCAACCC       TGATGAGCCCGAGAGGTATTGCAGTAGACAAGAATGGGCTCATGTACTTTGTCGATGCCACCATGATC       CGGAAGGTTGACCAGAATGGAATCATCTCCACCCTGCTGGGCTCCAATGACCTCACTGCCGTCCGGCC       GCTGAGCTGTGATTCCAGCATGGATGTAGCCCAAGTTCGTCTGGAGTGGCCAACAGACCTTGCTGTCA       ATCCCATGGATAACTCCTTGTATGTTCTAGAGAACAATGTCATCCTTCGAATCACCGAGAACCACCAA       GTCAGCATCATTGCGGGACGCCCCATGCACTGCCAAGTTCCTGGCATTGACTACTCACTCAGCAAACT       AGCCATTCACTCTGCCCTGGAGTCAGCCAGTGCCATTGCCATTTCTCACACTGGGGTCCTCTACATCA       CTGAGACAGATGAGAAGAAGATTAACCGTCTACGCCAGGTAACAACCAACGGGGAGATCTGCCTTTTA       GCTGGGGCAGCCTCGGACTGCGACTGCAAAAACGATGTCAATTGCAACTGCTATTCAGGAGATGATGC       CTACGCGACTGATGCCATCTTGAATTCCCCATCATCCTTAGCTGTAGCTCCAGATGGTACCATTTACA       TTGCAGACCTTGGAAATATTCGGATCAGGGCGGTCAGCAAGAACAAGCCTGTTCTTAATGCCTTCAAC       CAGTATGAGGCTGCATCCCCCGGAGAGCAGGAGTTATATGTTTTCAACGCTGATGGCATCCACCAATA       CACTGTGAGCCTGGTGACAGGGGAGTACTTGTACAATTTCACATATAGTACTGACAATGATGTCACTG       AATTGATTGACAATAATGGGAATTCCCTGAAGATCCGTCGGGACAGCAGTGGCATGCCCCGTCACCTG       CTCATGCCTGACAACCAGATCATCACCCTCACCGTGGGCACCAATGGAGGCCTCAAAGTCGTGTCCAC       ACAGAACCTGGAGCTTGGTCTCATGACCTATGATGGCAACACTGGGCTCCTGGCCACCAAGAGCGATG       AAACAGGATGGACGACTTTCTATAGCTATGACCACGAAGGCCGCCTGACCAACGTGACGCGCCCCACG       GGGGTGGTAACCAGTCTGCACCGGGAAATGGAGAAATCTATTACCATTGACATTGAGAACTCCAACCG       TGATGATGACGTCACTGTCATCACCAACCTCTCTTCAGTAGAGGCCTCCTACACAGTGGTACAAGATC       AAGTTCGGAACAGCTACCAGCTCTGTAATAATGGTACCCTGAGGGTGATGTATGCTAATGGGATGGGT       ATCAGCTTCCACAGCGAGCCCCATGTCCTAGCGGGCACCATCACCCCCACCATTGGACGCTGCAACAT       CTCCCTGCCTATGGAGAATGGCTTPAACTCCATTGAGTGGCGCCTAAGAPAGGAACAGATTAAAGGCA       AAGTCACCATCTTTGGCAGGAAGCTCGAGGTCCATGGAAGAAATCTCTTGTCCATTGACTATGATCGA       AATATTCGGACTGAAAAGATCTATGATGACCACCGGAAGTTCACCCTGAGGATCATTTATGACCAGGT       GGGCCGCCCCTTCCTCTGGCTGCCCAGCAGCGGGCTGGCAGCTGTCAACGTGTCATACTTCTTCAATG       GGCGCCTGGCTGGGCTTCAGCGTGGGGCCATGAGCGAGAGGACAGACATCGACAAGCAAGGCCGCATC       GTGTCCCGCATGTTCGCTGACGGGAAAGTGTGGAGCTACTCCTACCTTGACAAGATGGTCCTCCTGCT       TCAGAGCCAACGTCAGTATATATTTGAGTATGACTCCTCTGACCGCCTCCTTGCCGTCACCATGCCCA       GCGTGGCCCGGCACAGCATGTCCACACACACCTCCATCGGCTACATCCGTAATATTTACAACCCGCCT       GAAAGCAATGCTTCGGTCATCTTTGACTACAGTGATGACGGCCGCATCCTGAAGACCTCCTTTTTGGG       CACCGGACGCCAGGTGTTCTACAAGTATGGGAAACTCTCCAAGTTATCAGAGATTGTCTACGACAGTA       CCGCCGTCACCTTCGGGTATGACGAGACCACTGGTGTCTTGAAGATGGTCAACCTCCAAAGTGGGGGC       TTCTCCTGCACCATCAGGTACCGGAAGATTGGCCCCCTGGTGGACAAGCAGATCTACAGGTTCTCCGA       GGAAGGCATGGTCAATGCCAGGTTTGACTACACCTATCATGACAACAACTTCCGCATCGCAAGCATCA       AGCCCGTCATAAGTGAGACTCCCCTCCCCGTTGACCTCTACCGCTATGATGAGATTTCTGGCAAGGTG       GAACACTTTGGTAAGTTTGGAGTCATCTATTATGACATCAACCAGATCATCACCACTGCCGTGATGAC       CCTCAGCAAACACTTCGACACCCATGGGCGGATCAAGGAGGTCCAGTATGAGATGTTCCGGTCCCTCA       TGTACTGGATGACGGTGCAATATGACAGCATGGGCAGGGTGATCAAGAGGGAGCTAAAACTGGGGCCC       TATGCCAATACCACGAAGTACACCTATGACTACGATGGGGACGGGCAGCTCCAGAGCGTGCCGGCCGT       CAATGACCGCCCGACCTGGCGCTACAGCTATGACCTTAATGGGAATCTCCACTTACTGAACCCAGGCA       ACAGTGTGCGCCTCATGCCCTTGCGCTATGACCTCCGGGATCGGATAACCAGACTCGGGGATGTGCAG       TACAAAATTGACGACGATGGCTATCTGTGCCAGAGAGGGTCTGACATCTTCGAATACAATTCCAAGGG       CCTCCTAACAAGAGCCTACAACAAGGCCAGCGGGTGGAGTGTCCAGTACCGCTATGATGGCGTAGGAC       GGCGGGCTTCCTACAAGACCAACCTGGGCCACCACCTGCAGTACTTCTACTCTGACCTCCACAACCCG       ACGCGCATCACCCATGTCTACAATCACTCCAACTCGGAGATTACCTCACTGTACTACGACCTCCAGGG       CCACCTCTTTGCCATGGAGAGCAGCAGTGGGGAGGAGTACTATGTTGCCTCTGATAACACAGGGACTC       CTCTGGCTGTGTTCAGCATCAACGGCCTCATGATCAAACAGCTGCAGTACACGGCCTATGGGGAGATT       TATTATGACTCCAACCCCGACTTCCAGATGGTCATTGGCTTCCATGGGGGACTCTATGACCCCCTGAC       CAAGCTGGTCCACTTCACTCAGCGTGATTATGATGTGCTGGCAGGACGATGGACCTCCCCAGACTATA       CCATGTGGAAAAACGTGGGCAAGGAGCCGGCCCCCTTTAACCTGTATATGTTCAAGAGCAACAATCCT       CTCAGCAGTGAGCTAGATTTGAAGAACTACGTGACAGATGTGAAAAGCTGGCTTGTGATGTTTGGATT       TCAGCTTAGCAACATCATTCCTGGCTTCCCGAGAGCCAAAATGTATTTCGTGCCTCCTCCCTATGAAT       TGTCAGAGAGTCAAGCAAGTGAGAATGGACAGCTCATCACAGGTGCCCACCAGACAACAGAGAGACAT       AACCAGGCTTTCATGGCTCTGGAAGGACAGGTCATTACTAkAAAGCTCCACGCCAGCATCCGAGAGAA       AGCAGGTCATTGGTTTGCCACCACCACGCCCATCATTGGCAAAGGCATCATGTTTGCCATCAAAGAAG       GGCGGGTGACCACGGGCGTGTCCAGCATCGCCAGCGAAGATAGCCGCAAGGTGGCATCTGTGCTGAAC       AACGCCTACTACCTGGACAAGATGCACTACAGCATCGAGGGCAAGGACACCCACTACTTTGTGAAGAT       TGGCTCAGCCGATGGCGACCTGGTCACACTAGGCACCACCATCGGCCGCAAGGTGCTAGAGAGCGGGG       TGAACGTGACCGTGTCCCAGCCCACGCTGCTGGTCAACGGCAGGACTCGAAGGTTCACGAACATTGAG       TTCCAGTACTCCACGCTGCTGCTCAGCATCCGCTATGGCCTCACCCCCGACACCCTGGACGAAGAGAA       GGCCCGCGTCCTGGACCAGGCGAGACAGAGGGCCCTGGGCACGGCCTGGGCCAAGGAGCAGCAGAAAG       CCAGGGACGGGAGAGAGGGGAGCCGCCTGTGGACTGAGGGCGAGAAGCAGCAGCTTCTGAGCACCGGG       CGCGTGCAAGGGTACGAGGGATATTACGTGCTTCCCGTGGAGCAATACCCAGAGCTTGCAGACAGTAG       CAGCAACATCCAGTTTTTAAGACAGAATGAGATGGGAAAGAGG TAA   CAAAATAATCTGCTGCCATTCC           TTGTCTGAATGGCTCAGCAGGAGTAACTGTTATCTCCTCTCCTAAGGAGATGAAGACCTAACAGGGGC           ACTGCGG                                                    NOV7ab, CG50426-24   SEQ ID NO: 168   2759 aa   MW at 306902.2kD               Protein Sequence                     MDVKERRPYCSLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSSRLLYGNRVKDLVH           READEFTRQSRMHYGNRVTDLIHRESDEFPRQGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGI       KSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPRTSSRSLLPFVQLPSSHNPPPVSCQMPLLDSN       TSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNR       NSLTNPRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLT       SGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFAAMHLLGLNWQLQP       ADGHTFNNGIRTGLPGNDDVATMPSGGKVPWSLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQP       QFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYL       DVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCS       GNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSH       GVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVVCSVDCGTHGVC       IGGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIDGCPDLCNGNGRCTLGQNS       WQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDIISQSLQ       SPSQQAAKSFYDRISFLIGSDSTHVIPGESPFNSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTI       TRQDGTYSLSRFDLIANGGASLTLHFERAPFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGF       CRLDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTV       PLNLIRVHLMVAVEGHLFQKSFQASPNLAYTFIWDKTDAYGQRVYGLSDAVGMFWFQRTALLQGFELD       PSNLGGWSLDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAP       VALAVGIDGSLYVGDFNYIRRIFPSRNVTSILELRRNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNS       RRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDAT       MIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVRLEWPTDIAVNPMDNSLYVLENNVILRITEN       HQVSIIAGRPMHCQVPGIDYSLSKLAIHSALESASAIAISHTGVLYITETDEKKINRLRQVTTNGEIC       LLAGAASDCDCKNDVNCNCYSGDDAYATDATLNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNA       FNQYEAASPGEQELYVFNADGIHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPR       HLLMPDNQIITLTVGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYSYDHEGRLTNVTR       PTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANG       MGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLEVHGRNLLSIDY       DRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQG       RIVSRMFADGKVWSYSYLDKMVLLLQSQRQYIFEYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYN       PPESNASVIFDYSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQS       GGFSCTIRYRKIGPLVDKQIYRFSEEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISG       KVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKL       GPYANTTKYTYDYDGDGQLQSVPAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGD       VQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGWSVQYRYDGVGRRASYKTNLGHHLQYFYSDLH       NPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYG       EIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDYTMWKNVGKEPAPFNLYMFKSN       NPLSSELDLKNYVTDVKSWLVMFGFQLSNIIPGFPRAKMYFVPPPYELSESQASENGQLITGAHQTTE       RHNQAFMALEGQVITKKLHASIREKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASV       LNNAYYLDKMHYSIEGKDTHYFVKIGSADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTN       IEFQYSTLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLS       TGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR                                             NOV7ac, CG50426-25   SEQ ID NO: 169   6999 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     AAAAACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGG           GGTGTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGA       AGGACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTATGACTTCATG       GAACGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGAC       CTTGGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACA       ATGATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCAGGACTGTCCA       CGTAACTGCCATGGGAATGGTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGC       AGACTGTGCTAAAGCTGCCTGCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAAGGGACGTGCC       AGTGCTACAGCGGCTGGAAAGGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGATCCTTCCTGC       GGGGGCCACGGCTCCTGCATTGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCGAGCACTGTGA       GGAAGTTGATTGCTTGGATCCCACCTGCTCCAGCCACGGAGTCTGTGTGAATGGAGAATGCCTGTGCA       GCCCTGGCTGGGGTGGTCTGAACTGTGAGCTGGCGAGGGTCCAGTGCCCAGACCAGTGCAGTGGGCAT       GGCACGTACCTGCCTGACACGGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCGACTGCTCTGT       TGAAGTGTGCTCAGTAGACTGTGGCACTCACGGCGTCTGCATCGGGGGAGCCTGCCGCTGTGAAGAGG       GCTGGACAGGCGCAGCGTGTGACCAGCGCGTGTGCCACCCCCGCTGCATTGAGCACGGGACCTGTAAA       GATGGCAAATGTGAATGCCGAGAGGGCTGGAATGGTGAACACTGCACCATTGGTAGGCAAACGGCAGG       CACCGAAACAGATGGCTGCCCTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGTCAGAACAGCT       GGCAGTGTGTCTGCCAGACCGGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAACTTCCTGTGCT       GATAACAAGGATAATGAGGGAGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCCTGCAGTCAGC       CTGTCAGAACAGCCTGCTCTGCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAGGGCCAGACGG       ATTGGCCCGCAGTGAAGTCCTTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAGCACCCACATC       ATTCCTGGAGAGAACCCTTTCAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAGTAACTACAGA       TGGAACTCCCCTGGTCGGTGTGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTACACCATCACCC       GCCAGGATGGCACGTTCGACCTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTTTGAGCGAGCC       CCGTTCATGAGCCAGGAGCGCACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGGACACCCTGGT       GATGAAGACCGAGGAGAACTCCATCCCCAGCTGTGACCTCAGTGGCTTTGTCCGGCCTGATCCAATCA       TCATCTCCTCCCCACTGTCCACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGTGCCTGAGACC       CAGGTTCTTCATGAAGAAATCGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGAGCTCTAGAAC       TGCAGGGTACAAGTCACTGCTGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAACCTCATTAGGG       TTCACCTGATGGTGGCTGTCGAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCCCAACCTGGCC       GTCTGTCGGGTTTGAATATGAGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACAGCCCTCCTTC       AGGGATTCGAGCTGGACCCCTCCAACCTCGGTGGCTGGTCCCTAGACAAACACCACATCCTCAATGTT       AAAAGTGGAATCCTACACAAAGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTGCCATCATCAC       CAGCATCATGGGCAATGGTCGCCGCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTTGCTGAAGGCA       ACAAGCTGCTGGCCCCAGTGGCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGGTGACTTCAAT       TACATCCGACGCATCTTTCCCTCTCGAAATGTGACCAGCATCTTGGAGTTACGAAATAAAGAGTTTAA       ACATAGCAACAACCCAGCACACAAGTACTACTTGGCAGTGGACCCCGTGTCCGGCTCGCTCTACGTGT       CCGACACCAACAGCAGGAGAATCTACCGCGTCAAGTCTCTGAGTGGAACCAAAGACCTGGCTGGGAAT       TCGGAAGTTGTGGCAGGGACGGGAGAGCAGTGTCTACCCTTTGATGAAGCCCGCTGCGGGGATGGAGG       GAAGGCCATAGATGCAACCCTGATGAGCCCGAGAGGTATTGCAGTAGACAAGAATGGGCTCATGTACT       TTGTCGATGCCACCATGATCCGGAAGGTTGACCAGAATGGAATCATCTCCACCCTGCTGGGCTCCAAT       GACCTCACTGCCGTCCGGCCGCTGAGCTGTGATTCCAGCATGGATGTAGCCCAGGTTCGTCTGGAGTG       GCCAACAGACCTTGCTGTCAATCCCATGGATAACTCCTTGTATGTTCTAGAGAACAATGTCATCCTTC       GAATCACCGAGAACCACCAAGTCAGCATCATTGCGGGACGCCCCATGCACTGCCAAGTTCCTGGCATT       GACTACTCACTCAGCAAACTAGCCATTCACTCTGCCCTGGAGTCAGCCAGTGCCATTGCCATTTCTCA       CACTGGGGTCCTCTACATCACTGAGACAGATGAGAAGAAGATTAACCGTCTACGCCAGGTAACAACCA       ACGGGGAGATCTGCCTTTTAGCTGGGGCAGCCTCGGACTGCGACTGCAAAAACGATGTCAATTGCAAC       TGCTATTCAGGAGATGATGCCTACGCGACTGATGCCATCTTGAATTCCCCATCATCCTTAGCTGTAGC       TCCAGATGGTACCATTTACATTGCAGACCTTGGAAATATTCGGATCAGGGCGGTCAGCAAGAACAAGC       CTGTTCTTAATGCCTTCAACCAGTATGAGGCTGCATCCCCCGGAGAGCAGGAGTTATATGTTTTCAAC       GCTGATGGCATCCACCAATACACTGTGAGCCTGGTGACAGGGGAGTACTTGTACAATTTCACATATAG       TACTGACAATGATGTCACTGAATTGATTGACAATAATGGGAATTCCCTGAAGATCCGTCGGGACAGCA       GTGGCATGCCCCGTCACCTGCTCATGCCTGACAACCAGATCATCACCCTCACCGTGGGCACCAATGGA       GGCCTCAAAGTCGTGTCCACACAGAACCTGGAGCTTGGTCTCATGACCTATGATGGCAACACTGGGCT       CCTGGCCACCAAGAGCGATGAAACAGGATGGACGACTTTCTATGACTATGACCACGAAGGCCGCCTGA       CCAACGTGACGCGCCCCACGGGGGTGGTAACCAGTCTGCACCGGGAAATGGAGAAATCTATTACCATT       GACATTGAGAACTCCAACCGTGATGATGACGTCACTGTCATCACCAACCTCTCTTCAGTAGAGGCCTC       CTACACAGTGGTACAAGATCAAGTTCGGAACAGCTACCAGCTCTGTAATAATGGTACCCTGAGGGTGA       TGTATGCTAATGGGATGGGTATCAGCTTCCACAGCGAGCCCCATGTCCTAGCGGGCACCATCACCCCC       ACCATTGGACGCTGCAACATCTCCCTGCCTATGGAGAATGGCTTAAACTCCATTGAGTGGCGCCTAAG       AAAGGAACAGATTAAAGGCAAAGTCACCATCTTTGGCAGGAAGCTCCGGGTCCATGGAAGAAATCTCT       TGTCCATTGACTATGATCGAAATATTCGGACTGAAAAGATCTATGATGACCACCGGAAGTTCACCCTG       AGGATCATTTATGACCAGGTGGGCCGCCCCTTCCTCTGGCTGCCCAGCAGCGGGCTGGCAGCTGTCAA       CGTGTCATACTTCTTCAATGGGCGCCTGGCTGGGCTTCAGCGTGGGGCCATGAGCGAGAGGACAGACA       TCGACAAGCAAGGCCGCATCGTGTCCCGCATGTTCGCTGACGGGAAAGTGTGGAGCTACTCCTACCTT       GACAAGTCCATGGTCCTCCTGCTTCAGAGCCAACGTCAGTATATATTTGAGTATGACTCCTCTGACCG       CCTCCTTGCCGTCACCATGCCCAGCGTGGCCCGGCACAGCATGTCCACACACACCTCCATCGGCTACA       TCCGTAATATTTACAACCCGCCTGAAAGCAATGCTTCGGTCATCTTTGACTACAGTGATGACGGCCGC       ATCCTGAAGACCTCCTTTTTGGGCACCGGACGCCAGGTGTTCTACAAGTATGGGAAACTCTCCAAGTT       ATCAGAGATTGTCTACGACAGTACCGCCGTCACCTTCGGGTATGACGAGACCACTGGTGTCTTGAAGA       TGGTCAACCTCCAAAGTGGGGGCTTCTCCTGCACCATCAGGTACCGGAAGATTGGCCCCCTGGTGGAC       AAGCAGATCTACAGGTTCTCCGAGGAAGGCATGGTCAATGCCAGGTTTGACTACACCTATCATGACAA       CAGCTTCCGCATCGCAAGCATCAAGCCCGTCATAAGTGAGACTCCCCTCCCCGTTGACCTCTACCGCT       ATGATGAGATTTCTGGCAAGGTGGAACACTTTGGTAAGTTTGGAGTCATCTATTATGACATCAACCAG       ATCATCACCACTGCCGTGATGACCCTCAGCAAACACTTCGACACCCATGGGCGGATCAAGGAGGTCCA       GTATGAGATGTTCCGGTCCCTCATGTACTGGATGACGGTGCAATATGACAGCATGGGCAGGGTGATCA       AGAGGGAGCTAAAACTGGGGCCCTATGCCAATACCACGAAGTACACCTATGACTACGATGGGGACGGG       CAGCTCCAGAGCGTGGCCGTCAATGACCGCCCGACCTGGCGCTACAGCTATGACCTTAATGGGAATCT       CCACTTACTGAACCCAGGCAACAGTGTGCGCCTCATGCCCTTGCGCTATGACCTCCGGGATCGGATAA       CCAGACTCGGGGATGTGCAGTACAAAATTGACGACGATGGCTATCTGTGCCAGAGAGGGTCTGACATC       TTCGAATACAATTCCAAGGGCCTCCTAACAAGAGCCTACAACAAGGCCAGCGGGTGGAGTGTCCAGTA       CCGCTATGATGGCGTAGGACGGCGGGCTTCCTACAAGACCAACCTGGGCCACCACCTGCAGTACTTCT       ACTCTGACCTCCACAACCCGACGCGCATCACCCATGTCTACAATCACTCCAACTCGGAGATTACCTCA       CTGTACTACGACCTCCAGGGCCACCTCTTTGCCATGGAGAGCAGCAGTGGGGAGGAGTACTATGTTGC       CTCTGATAACACAGGGACTCCTCTGGCTGTGTTCAGCATCAACGGCCTCATGATCAAACAGCTGCAGT       ACACGGCCTATGGGGAGATTTATTATGACTCCAACCCCGACTTCCAGATGGTCATTGGCTTCCATGGG       GGACTCTATGACCCCCTGACCAAGCTGGTCCACTTCACTCAGCGTGATTATGATGTGCTGGCAGGACG       ATGGACCTCCCCAGACTATACCATGTGGAAAAACGTGGGCAAGGAGCCGGCCCCCTTTAACCTGTATA       TGTTCAAGAGCAACAATCCTCTCAGCAGTGAGCTAGATTTGAAGAACTACGTGACAGATGTGAAAAGC       TGGCTTGTGATGTTTGGATTTCAGCTTAGCAACATCATTCCTGGCTTCCCGAGAGCCAAAATGTATTT       CGTGCCTCCTCCCTATGAATTGTCAGAGAGTCAAGCAAGTGAGAATGGACAGCTCATTACAGGTGTCC       AACAGACAACAGAGAGACATAACCAGGCCTTCATGGCTCTGGAAGGACAGGTCATTACTAAAAAGCTC       CACGCCAGCATCCGAGAGAAAGCAGGTCACTGGTTTGCCACCACCACGCCCATCATTGGCAAAGGCAT       CATGTTTGCCATCAAAGAAGGGCGGGTGACCACGGGCGTGTCCAGCATCGCCAGCGAAGATAGCCGCA       AGGTGGCATCTGTGCTGAACAACGCCTACTACCTGGACAAGATGCACTACAGCATCGAGGGCAAGGAC       ACCCACTACTTTGTGAAGATTGGCTCAGCCGATGGCGACCTGGTCACACTAGGCACCACCATCGGCCG       CAAGGTGCTAGAGAGCGGGGTGAACGTGACCGTGTCCCAGCCCACGCTGCTGGTCAACGGCAGGACTC       GAAGGTTCACGAACATTGAGTTCCAGTACTCCACGCTGCTGCTCAGCATCCGCTATGGCCTCACCCCC       GACACCCTGGACGAAGAGAAGGCCCGCGTCCTGGACCAGGCGAGACAGAGGGCCCTGGGCACGGCCTG       GGCCAAGGAGCAGCAGAAAGCCAGGGACGGGAGAGAGGGGAGCCGCCTGTGGACTGAGGGCGAGAAGC       AGCAGCTTCTGAGCACCGGGCGCGTGCAAGGGTACGAGGGATATTACGTGCTTCCCGTGGAGCAATAC       CCAGAGCTTGCAGACAGTAGCAGCAACATCCAGTTTTTAAGACAGAATGAGATGGGAAAGAGG                                                 NOV7ac, CG50426-25   SEQ ID NO: 170   2333 aa   MW at 259545.2kD               Protein Sequence                     KNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFM           ERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCP       RNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSC       GGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGH       GTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCK       DGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCA       DNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHI       IPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERA       PFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPET       QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLA       STFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNV       KSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFN       YIRRIFPSRNVTSILELRNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGN       SEVVAGTGEQCLPFDEARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSN       DLTAVRPLSCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGI       DYSLSKLAIHSALESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCN       CYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFN       ADGIHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNG       GLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITI       DIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMGISFHSEPHVLAGTITP       TIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTL       RIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYL       DKSMVLLLQSQRQYIFEYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGR       ILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVD       KQIYRFSEEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQ       IITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDG       QLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGDVQYKIDDDGYLCQRGSDI       FEYNSKGLLTRAYNKASGWSVQYRYDGVGRPASYKTNLGHHLQYFYSDLHNPTRITHVYNHSNSEITS       LYYDLQGHLFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHG       GLYDPLTKLVHFTQRDYDVLAGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKS       WLVMFGFQLSNIIPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKL       HASIREKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKD       THYFVKIGSADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYSTLLLSIRYGLTP       DTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQY       PELADSSSNIQFLRQNEMGKR                                     NOV7ad, SNP13375665 of   SEQ ID NO: 171   2478 bp           1CG50426-15, DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence           SNP Pos: 799   SNP Change: G to A                     AAAAACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGG           GGTGTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGA       AGGACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTATGACTTCATG       GAACGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGAC       CTTGGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACA       ATGATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCAGGACTGTCCA       CGTAACTGCCATGGGAATGGTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGC       AGACTGTGCTAAAGCTGCCTGCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAAGGGACGTGCC       AGTGCTACAGCGGCTGGAAAGGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGATCCTTCCTGC       GGGGGCCACGGCTCCTGCATTGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCGAGCACTGTGA       GGAAGTTGATTGCTTGGATCCCACCTGCTCCAGCCACGGAGTCTGTGTGAATGGAGAATGCCTGTGCA       GCCCTGGCTGGGGTGGTCTGAACTGTGAGCTGGCGAGGGTCCAGTGCCCA   A   ACCAGTGCAGTGGGCAT       GGCACGTACCTGCCTGACACGGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCGACTGCTCTGT       TGAAGTGTGCTCAGTAGACTGTGGCACTCACGGCGTCTGCATCGGGGGAGCCTGCCGCTGTGAAGAGG       GCTGGACAGGCGCAGCGTGTGACCAGCGCGTGTGCCACCCCCGCTGCATTGAGCACGGGACCTGTAAA       GATGGCAAATGTGAATGCCGAGAGGGCTGGAATGGTGAACACTGCACCATTGGTAGGCAAACGGCAGG       CACCGAAACAGATGGCTGCCCTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGTCAGAACAGCT       GGCAGTGTGTCTGCCAGACCGGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAACTTCCTGTGCT       GATAACAAGGATAATGAGGGAGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCCTGCAGTCAGC       CTGTCAGAACAGCCTGCTCTGCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAGGGCCAGACGG       ATTGGCCCGCAGTGAAGTCCTTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAGCACCCACATC       ATTCCTGGAGAGAACCCTTTCAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAGTAACTACAGA       TGGAACTCCCCTGGTCGGTGTGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTACACCATCACCC       GCCAGGATGGCACGTTCGACCTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTTTGAGCGAGCC       CCGTTCATGAGCCAGGAGCGCACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGGACACCCTGGT       GATGAAGACCGAGGAGAACTCCATCCCCAGCTGTGACCTCAGTGGCTTTGTCCGGCCTGATCCAATCA       TCATCTCCTCCCCACTGTCCACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGTGCCTGAGACC       CAGGTTCTTCATGAAGAAATCGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGAGCTCTAGAAC       TGCAGGGTACAAGTCACTGCTGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAACCTCATTAGGG       TTCACCTGATGGTGGCTGTCGAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCCCAACCTGGCC       TCCACCTTCATCTGGGACAAGACAGATGCGTATGGCCAAAGGGTGTATGGACTCTCAGATGCTGTTGT       GTCTGTCGGGTTTGAATATGAGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACAGCCCTCCTTC       AGGGATTCGAGCTGGACCCCTCCAACCTCGGTGGCTGGTCCCTAGACAAACACCACATCCTCAATGTT       AAAAGTGGAATCCTACACAAAGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTGCCATCATCAC       CAGCATCATGGGCAATGGTCGCCGCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTTGCTGAAGGCA       ACAAGCTGCTGGCCCCAGTGGCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGGTGACTTCAAT       TACATCCGACGCATCTTTCCCTCTCGAAAT                                         NOV7ad, SNP13375665 of   SEQ ID NO: 172   826 aa   MW at 89832.6kD           CG50426-15, Protein   SNP Pos: 267   SNP Change: Asp to Asn       Sequence                     KNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFM           ERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCP       RNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSC       GGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCP   N   QCSGH       GTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCK       DGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCA       DNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHI       IPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERA       PFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPET       QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLA       STFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNV       KSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFN       YIRRIFPSRN                                     NOV7ae, SNP13375213 of   SEQ ID NO: 173   2478 bp           CG50426-15, DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence           SNP Pos: 1751   SNP Change: T to C                     AAAAACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGG           GGTGTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGA       AGGACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTATGACTTCATG       GAACGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGAC       CTTGGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACA       ATGATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCAGGACTGTCCA       CGTAACTGCCATGGGAATGGTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGC       AGACTGTGCTAAAGCTGCCTGCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAAGGGACGTGCC       AGTGCTACAGCGGCTGGAAAGGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGATCCTTCCTGC       GGGGGCCACGGCTCCTGCATTGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCGAGCACTGTGA       GGAAGTTGATTGCTTGGATCCCACCTGCTCCAGCCACGGAGTCTGTGTGAATGGAGAATGCCTGTGCA       GCCCTGGCTGGGGTGGTCTGAACTGTGAGCTGGCGAGGGTCCAGTGCCCAGACCAGTGCAGTGGGCAT       GGCACGTACCTGCCTGACACGGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCGACTGCTCTGT       TGAAGTGTGCTCAGTAGACTGTGGCACTCACGGCGTCTGCATCGGGGGAGCCTGCCGCTGTGAAGAGG       GCTGGACAGGCGCAGCGTGTGACCAGCGCGTGTGCCACCCCCGCTGCATTGAGCACGGGACCTGTAAA       GATGGCAAATGTGAATGCCGAGAGGGCTGGAATGGTGAACACTGCACCATTGGTAGGCAAACGGCAGG       CACCGAAACAGATGGCTGCCCTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGTCAGAACAGCT       GGCAGTGTGTCTGCCAGACCGGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAACTTCCTGTGCT       GATAACAAGGATAATGAGGGAGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCCTGCAGTCAGC       CTGTCAGAACAGCCTGCTCTGCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAGGGCCAGACGG       ATTGGCCCGCAGTGAAGTCCTTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAGCACCCACATC       ATTCCTGGAGAGAACCCTTTCAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAGTAACTACAGA       TGGAACTCCCCTGGTCGGTGTGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTACACCATCACCC       GCCAGGATGGCACGTTCGACCTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTTTGAGCGAGCC       CCGTTCATGAGCCAGGAGCGCACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGGACACCCTGGT       GATGAAGACCGAGGAGAACTCCATCCCCAGCTGTGACCTCAGTGGCTTTG   C   CCGGCCTGATCCAATCA       TCATCTCCTCCCCACTGTCCACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGTGCCTGAGACC       CAGGTTCTTCATGAAGAAATCGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGAGCTCTAGAAC       TGCAGGGTACAAGTCACTGCTGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAACCTCATTAGGG       TTCACCTGATGGTGGCTGTCGAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCCCAACCTGGCC       TCCACCTTCATCTGGGACAAGACAGATGCGTATGGCCAAAGGGTGTATGGACTCTCAGATGCTGTTGT       GTCTGTCGGGTTTGAATATGAGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACAGCCCTCCTTC       AGGGATTCGAGCTGGACCCCTCCAACCTCGGTGGCTGGTCCCTAGACAAACACCACATCCTCAATGTT       AAAAGTGGAATCCTACACAAAGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTGCCATCATCAC       CAGCATCATGGGCAATGGTCGCCGCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTTGCTGAAGGCA       ACAAGCTGCTGGCCCCAGTGGCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGGTGACTTCAAT       TACATCCGACGCATCTTTCCCTCTCGAAAT                                         NOV7ae, SNP13375213 of   SEQ ID NO: 174   826 aa   MW at 89805.5kD           CG50426-15, Protein   SNP Pos: 584   SNP Change: Val to Ala       Sequence                     KNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFM           ERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCP       RNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSC       GGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGH       GTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCK       DGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCA       DNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHI       IPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERA       PFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGF   A   RPDPIIISSPLSTFFSAAPGQNPIVPET       QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLA       STFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNV       KSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFN       YIRRIFPSRN                                     NOV7af, SNP13374985 of   SEQ ID NO: 175   2478 bp           CG50426-15, DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence           SNP Pos: 2322   SNP Change: G to A                     AAAAACAGCAGCATAGACAGTGGTGAAGCAGAAGTTGGTCGGCGGGTAACACAAGAAGTCCCACCAGG           GGTGTTTTGGAGGTCACAAATTCACATCAGTCAGCCCCAGTTCTTAAAGTTCAACATCTCCCTCGGGA       AGGACGCTCTCTTTGGTGTTTACATAAGAAGAGGACTTCCACCATCTCATGCCCAGTATGACTTCATG       GAACGTCTGGACGGGAAGGAGAAGTGGAGTGTGGTTGAGTCTCCCAGGGAACGCCGGAGCATACAGAC       CTTGGTTCAGAATGAAGCCGTGTTTGTGCAGTACCTGGATGTGGGCCTGTGGCATCTGGCCTTCTACA       ATGATGGAAAAGACAAAGAGATGGTTTCCTTCAATACTGTTGTCCTAGATTCAGTGCAGGACTGTCCA       CGTAACTGCCATGGGAATGGTGAATGTGTGTCCGGGGTGTGTCACTGTTTCCCAGGATTTCTAGGAGC       AGACTGTGCTAAAGCTGCCTGCCCTGTCCTGTGCAGTGGGAATGGACAATATTCTAAAGGGACGTGCC       AGTGCTACAGCGGCTGGAAAGGTGCAGAGTGCGACGTGCCCATGAATCAGTGCATCGATCCTTCCTGC       GGGGGCCACGGCTCCTGCATTGATGGGAACTGTGTCTGCTCTGCTGGCTACAAAGGCGAGCACTGTGA       GGAAGTTGATTGCTTGGATCCCACCTGCTCCAGCCACGGAGTCTGTGTGAATGGAGAATGCCTGTGCA       GCCCTGGCTGGGGTGGTCTGAACTGTGAGCTGGCGAGGGTCCAGTGCCCAGACCAGTGCAGTGGGCAT       GGCACGTACCTGCCTGACACGGGCCTCTGCAGCTGCGATCCCAACTGGATGGGTCCCGACTGCTCTGT       TGAAGTGTGCTCAGTAGACTGTGGCACTCACGGCGTCTGCATCGGGGGAGCCTGCCGCTGTGAAGAGG       GCTGGACAGGCGCAGCGTGTGACCAGCGCGTGTGCCACCCCCGCTGCATTGAGCACGGGACCTGTAAA       GATGGCAAATGTGAATGCCGAGAGGGCTGGAATGGTGAACACTGCACCATTGGTAGGCAAACGGCAGG       CACCGAAACAGATGGCTGCCCTGACTTGTGCAACGGTAACGGGAGATGCACACTGGGTCAGAACAGCT       GGCAGTGTGTCTGCCAGACCGGCTGGAGAGGGCCCGGATGCAACGTTGCCATGGAAACTTCCTGTGCT       GATAACAAGGATAATGAGGGAGATGGCCTGGTGGATTGTTTGGACCCTGACTGCTGCCTGCAGTCAGC       CTGTCAGAACAGCCTGCTCTGCCGGGGGTCCCGGGACCCACTGGACATCATTCAGCAGGGCCAGACGG       ATTGGCCCGCAGTGAAGTCCTTCTATGACCGTATCAAGCTCTTGGCAGGCAAGGATAGCACCCACATC       ATTCCTGGAGAGAACCCTTTCAACAGCAGCTTGGTTTCTCTCATCCGAGGCCAAGTAGTAACTACAGA       TGGAACTCCCCTGGTCGGTGTGAACGTGTCTTTTGTCAAGTACCCAAAATACGGCTACACCATCACCC       GCCAGGATGGCACGTTCGACCTGATCGCAAATGGAGGTGCTTCCTTGACTCTACACTTTGAGCGAGCC       CCGTTCATGAGCCAGGAGCGCACTGTGTGGCTGCCGTGGAACAGCTTTTACGCCATGGACACCCTGGT       GATGAAGACCGAGGAGAACTCCATCCCCAGCTGTGACCTCAGTGGCTTTGTCCGGCCTGATCCAATCA       TCATCTCCTCCCCACTGTCCACCTTCTTTAGTGCTGCCCCTGGGCAGAATCCCATCGTGCCTGAGACC       CAGGTTCTTCATGAAGAAATCGAGCTCCCTGGTTCCAATGTGAAACTTCGCTATCTGAGCTCTAGAAC       TGCAGGGTACAAGTCACTGCTGAAGATCACCATGACCCAGTCCACAGTGCCCCTGAACCTCATTAGGG       TTCACCTGATGGTGGCTGTCGAGGGGCATCTCTTCCAGAAGTCATTCCAGGCTTCTCCCAACCTGGCC       TCCACCTTCATCTGGGACAGACAGATGCGTATGGCCAAAAGGGTGTATGGACTCTCAGATGCTGTTGT       GTCTGTCGGGTTTGAATATGAGACCTGTCCCAGTCTAATTCTCTGGGAGAAAAGGACAGCCCTCCTTC       AGGGATTCGAGCTGGACCCCTCCAACCTCGGTGGCTGGTCCCTAGACAAACACCACATCCTCAATGTT       AAAAGTGGAATCCTACACAAAGGCACTGGGGAAAACCAGTTCCTGACCCAGCAGCCTGCCATCATCAC       CAGCATCAT   A   GGCAATGGTCGCCGCCGGAGCATTTCCTGTCCCAGCTGCAACGGCCTTGCTGAAGGCA       ACAAGCTGCTGGCCCCAGTGGCTCTGGCTGTTGGAATCGATGGGAGCCTCTATGTGGGTGACTTCAAT       TACATCCGACGCATCTTTCCCTCTCGAAAT                                         NOV7af, SNP13374985 of   SEQ ID NO: 176   826 aa   MW at 89815.5kD           CG50426-15, Protein   SNP Pos: 774       SNP Change: Met to Ile       Sequence                     KNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFM           ERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCP       RNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSC       GGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGH       GTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCK       DGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCA       DNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHI       IPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERA       PFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPET       QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLA       STFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNV       KSGILHKGTGENQFLTQQPAIITSI   I   GNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFN       YIRRIFPSRN                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 7B.  
               TABLE 7B                       Comparison of the NOV7 protein sequences.                                            NOV7a   ------------------------------------------------------------           NOV7b   ------------------------------------------------------------       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   ------------------------------------------------------------       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   ------------------------------------------------------------       NOV7p   ------------------------------------------------------------       NOV7q   MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRNHYGNR       NOV7r   ------------------------------------------------------------       NOV7s   ------------------------------------------------------------       NOV7t   ------------------------------------------------------------       NOV7u   ------------------------------------------------------------       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   ------------------------------------------------------------       NOV7ac   ------------------------------------------------------------               NOV7a   ------------------------------------------------------------       NOV7b   ------------------------------------------------------------       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   ------------------------------------------------------------       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7O   ------------------------------------------------------------       NOV7p   ------------------------------------------------------------       NOV7q   VTDLIHRESDEFPRQGTNFTTAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTE       NOV7r   ------------------------------------------------------------       NOV7s   ------------------------------------------------------------       NOV7t   ------------------------------------------------------------       NOV7u   ------------------------------------------------------------       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   ------------------------------------------------------------       NOV7ac   ------------------------------------------------------------               NOV7a   ------------------------------------------------------------       NOV7b   --------------------------MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRV       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   ------------------------------------------------------------       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   ------------------------------------------------------------       NOV7p   ------------------------------------------------------------       NOV7q   GGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLL       NOV7r   ------------------------------------------------------------       NOV7s   ------------------------------------------------------------       NOV7t   ------------------------------------------------------------       NOV7u   ------------------------------------------------------------       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   --------------------------MDVKERRPYCSLTKSRREKERRYTNSSADNEECR       NOV7ac   ------------------------------------------------------------               NOV7a   ------------------------------------------------------------       NOV7b   PTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRESDEFPRQGTNFTLAELGICEPSPHRS       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   -------MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDS       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   ------------------------------------------------------------       NOV7p   ------------------------------------------------------------       NOV7q   PSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPP       NOV7r   -------MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDS       NOV7s   -------MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDS       NOV7t   ------------------------------------------------------------       NOV7u   -------MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDS       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   VPTQKSYSSSETLKAFDHDSSRLLYGNRVKDLVHREADEFTRQSRMHYGNRVTDLIHRES       NOV7ac   ------------------------------------------------------------               NOV7a   ------------------------------------------------------------       NOV7b   GYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTL       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   RMHYGNRVTDLIHRESDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGS       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   ----MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMH       NOV7p   ------------------------------------------------------------       NOV7q   NHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQ       NOV7r   RMHYGNRVTDLIHRESDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGS       NOV7s   RNHYGNRVTDLIHRESDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGS       NOV7t   ------------------------------------------------------------       NOV7u   RMHYGNRVTDLIHRESDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGS       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   DEFPRQGTLHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTL       NOV7ac   ------------------------------------------------------------               NOV7a   ------------------MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSS       NOV7b   TDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNP       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   DADSDTEGGNSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPP       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   YGNRVTDLIHRESDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDAD       NOV7p   ------------------------------------------------------------       NOV7q   LQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRK       NOV7r   DADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPP       NOV7s   DADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPP       NOV7t   ------------------------------------------------------------       NOV7u   DADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPP       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   TDSDNENKSDDENGRPIPRTSSRSLLPFVQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNP       NOV7ac   ------------------------------------------------------------               NOV7a   SETLKAYDHDSRMHYGNRVTDLIHRESDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGI       NOV7b   DEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNPNS       NOV7c   ----------------------------------------KNSSIDSGEAEVGRRVTQEV       NOV7d   -------------------------------------TKLKNSSIDSGEAEVGRRVTQEV       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   TSSPSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQ       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   SDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRBNSALTLTDSDNENKSDDENGRPIPPTSS       NOV7p   ------------------------------------------------------------       NOV7q   AFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKNSSIDSGEAEVGRRVTQEV       NOV7r   TSSPSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQ       NOV7s   TSSPSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLPACSGPQQ       NOV7t   ------------------------------------------------------------       NOV7u   TSSPSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQ       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   DEEFSPNSYLLEACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNPNS       NOV7ac   ------------------------------------------------------------               NOV7a   LHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSPRSSGLSSRENSALTLTDSDNENK       NOV7b   LTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSS       NOV7c   PPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVV       NOV7d   PPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVV       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------TKLKNSSIDSGE       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7l   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   ASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLA       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   PSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASS       NOV7p   ------------------------------------------------------------       NOV7q   PPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVV       NOV7r   ASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLA       NOV7s   ASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLA       NOV7t   ------------------------------------------------------------       NOV7u   ASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLA       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   LTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSS       NOV7ac   ------------------------------------------------------------               NOV7a   SDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEFSPNS       NOV7b   PGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYF       NOV7c   ESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCH       NOV7d   ESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCH       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   AEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFME       NOV7h   ------------------------------------------------------------       NOV7i   ---------------------------------------------MDVKDRRHRSLTRGR       NOV7j   ---------------------------------------------MDVKDRRHRSLTRGR       NOV7k   ---------------------------------------------MDVKDRRHRSLTRGR       NOV7l   TTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLP       NOV7m   -----------------------------------KHQHSAISGIMDVKDRRHRSLTRGR       NOV7n   -----------------------------------KHQHSAISGIMDVKDRRHRSLTRGR       NOV7o   SGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTP       NOV7p   -----------------------------------KHQHSAISGIMDVKDRRHRSLTRGR       NOV7q   ESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCH       NOV7r   TTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLP       NOV7s   TTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLP       NOV7t   -----------------------------------KHQHSAISGIMDVKDRRHRSLTRGR       NOV7u   TTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLP       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   PGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYF       NOV7ac   ------------------------------------------------------------               NOV7a   YLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNRRSQI       NOV7b   IAMHLLGLNWQLQPADGHTFNNGIRTGLPGNDDVATMPSGGKVPWSLKNSSIDSGEAEVG       NOV7c   GNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCI       NOV7d   GNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCI       NOV7e   --------------------------------------------TKLKNSSIDSGEAEVG       NOV7f   ------------------------------------------------------------       NOV7g   RLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVL       NOV7h   ------------------------------------------------------------       NOV7i   CGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRESDEFPRQ       NOV7j   CGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRESDEFPRQ       NOV7k   CGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRESDEFPRQ       NOV7l   RNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKNSSIDSGEAEVG       NOV7m   CGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRESDEFPRQ       NOV7n   CGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRESDEFPRQ       NOV7o   ESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNT       NOV7p   CGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRESDEFPRQ       NOV7q   GNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCI       NOV7r   RNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKNSSIDSGEAEVG       NOV7s   RNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKNSSIDSGEAEVG       NOV7t   CGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRESDEFPRQ       NOV7u   RNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKNSSIDSGEAEVG       NOV7v   -----------------------------------------------KNSSIDSGEAEVG       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   AAMHLLGLNWQLQPADGHTFNNGIRTGLPGNDDVATMPSGGKVPWSLKNSSIDSGEAEVG       NOV7ac   -----------------------------------------------KNSSIDSGEAEVG               NOV7a   HAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLTSG       NOV7b   RRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDG       NOV7c   DPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCEL       NOV7d   DPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCEL       NOV7e   RRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDG       NOV7f   -----------------------------------------TKLKNSSIDSGEAEVGRRV       NOV7g   DSVQDCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKG       NOV7h   ------------------------------------------------------------       NOV7i   GTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRG       NOV7j   GTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRG       NOV7k   GTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRG       NOV7l   RRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDG       NOV7m   GTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRG       NOV7n   GTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRG       NOV7o   FSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKNSSIDSGEAEVGRRV       NOV7p   GTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRG       NOV7q   DPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCEL       NOV7r   RRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDG       NOV7s   RRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDG       NOV7t   GTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRG       NOV7u   RRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDG       NOV7v   RRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDG       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   --------------------------------------------KNSSIDSGEAEVGRRV       NOV7ab   RRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDG       NOV7ac   RRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDG               NOV7a   TVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIVPWSLKN       NOV7b   KEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQ       NOV7c   ARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWT       NOV7d   ARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWT       NOV7e   KEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQ       NOV7f   TQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEK       NOV7g   AECDVPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLC       NOV7h   -----------------MLHAANKGRKPSAEAGRPIPPTSSPSLLPSAQLPSSHNPPPVS       NOV7i   IKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVS       NOV7j   IKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVS       NOV7k   IKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVS       NOV7l   KEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQ       NOV7m   IKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVS       NOV7n   IKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVS       NOV7o   TQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEK       NOV7p   IKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVS       NOV7q   ARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWT       NOV7r   KEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQ       NOV7s   KEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQ       NOV7t   IKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVS       NOV7u   KEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQ       NOV7v   KEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQ       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   -----------------------------------------------------------N       NOV7aa   TQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEK       NOV7ab   KEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQ       NOV7ac   KEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQ               NOV7a   SSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSH       NOV7b   DCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECD       NOV7c   GAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCT       NOV7d   GAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCT       NOV7e   DCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECD       NOV7f   WSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCP       NOV7g   SPGWGGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVDGCPDLCNGNGRCT       NOV7h   CQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPP       NOV7i   CQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPP       NOV7j   CQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPP       NOV7k   CQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPP       NOV7l   DCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECD       NOV7m   CQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPP       NOV7n   CQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPP       NOV7o   WSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCP       NOV7p   CQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPP       NOV7q   GAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCT       NOV7r   DCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECD       NOV7s   DCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECD       NOV7t   CQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPP       NOV7u   DCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECD       NOV7v   DCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECD       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   SSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSH       NOV7aa   WSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCP       NOV7ab   DCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECD       NOV7ac   DCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECD               NOV7a   AQYDFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMV       NOV7b   VPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGW       NOV7c   LGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRG       NOV7d   LGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRG       NOV7e   VPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGW       NOV7f   RNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPM       NOV7g   LGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRG       NOV7h   HNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLET       NOV7i   HNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLET       NOV7j   HNHTLSHHHSSANSLNENSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLET       NOV7k   HNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLET       NOV7l   VPNNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGW       NOV7m   HNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLET       NOV7n   HNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLET       NOV7o   RNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPM       NOV7p   HNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLET       NOV7q   LGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRG       NOV7r   VPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGW       NOV7s   VPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGW       NOV7t   HNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLET       NOV7u   VPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGW       NOV7v   VPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGW       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   AQYDFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMV       NOV7aa   RNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPM       NOV7ab   VPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGW       NOV7ac   VPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGW               NOV7a   SFNTVVLDS-VQDCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTC       NOV7b   GGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGAC       NOV7c   SRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIRGQVVTTDG       NOV7d   SRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIRGQVVTTDG       NQV7e   GGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGAC       NOV7f   NQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGL       NOV7g   SRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIRGQVVTTDG       NOV7h   RHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKC       NOV7i   RHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKC       NOV7j   RHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKC       NOV7k   RHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKC       NOV7l   GGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGAC       NOV7m   RHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKC       NOV7n   RHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKC       NOV7o   NQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGL       NOV7p   RHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKC       NOV7q   SRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIRGQVVTTDG       NOV7r   GGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGAC       NOV7s   GGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGAC       NOV7t   RHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKC       NOV7u   GGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGAC       NOV7v   GGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGAC       NOV7w   ------------------------DTGLCSCDPNWMGPDCSVE-----------------       NOV7x   ----------------------DRIKLLAGKDSTHIIPGE--------------------       NOV7y   ---------------------SAGYKGEHCEEVDCLDPTCS-------------------       NOV7z   SFNTVVLDDSVQDCPRNCHGNGECVSGVCHCFPGFLGADCAKDLPALTFCKTIINKAAL-       NOV7aa   NQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGL       NOV7ab   GGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVVCSVDCGTHGVCIGGACR       NOV7ac   GGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGAC               NOV7a   QCYSGWKGAECDVPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSNGV       NOV7b   RCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIDGCPDLCN--------       NOV7c   TPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERTVWLPWNSF       NOV7d   TPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERTVWLPWNSF       NOV7e   RCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIDGCPDLCNGNGRCTLG       NOV7f   NCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCE       NOV7g   TPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERTVWLPWNSF       NOV7h   AALSAIAAALLLAILLAYFIVPWSLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQP       NOV7i   AALSAIAAALLLAIL---------------------------------------------       NOV7j   AALSAIAAALLLAILLAYFIVPWSLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQP       NOV7k   AALSAIAAALLLAIL---------------------------------------------       NOV7l   RCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLC       NOV7m   AALSAIAAALLLAILLAYFIVPWSLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQP       NOV7n   AALSAIAAALLLAIL---------------------------------------------       NOV7o   NCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCE       NOV7p   AALSAIAAALLLAILLAYFIVPWSLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQP       NOV7q   TPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERTVWLPWNSF       NOV7r   RCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIDGCPDLCN--------       NOV7s   RCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLC       NOV7t   AALSAIAAALLLAIL---------------------------------------------       NOV7u   RCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLC       NOV7v   RCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLC       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   NCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCE       NOV7ab   CEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIDGCPDLCNG--------       NOV7ac   RCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLC               NOV7a   CVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVDGCPDL       NOV7b   -GNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQ       NOV7c   YAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIE       NOV7d   YAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIE       NOV7e   QNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSR       NOV7f   EGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIDGCPDLCNGNGRCTLGQNS       NOV7g   YAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIE       NOV7h   QFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPRERRSIQTLVQN       NOV7i   ------------------------------------------------------------       NOV7j   QFLKFNTSLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPRERRSIQTLVQN       NOV7k   ------------------------------------------------------------       NOV7l   NGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQ       NOV7m   QFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPRERRSIQTLVQN       NOV7n   ------------------------------------------------------------       NOV7o   EGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGN       NOV7p   QFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPRERRSIQTLVQN       NOV7q   YAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIE       NOV7r   -GNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQ       NOV7s   NGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQ       NOV7t   ------------------------------------------------------------       NOV7u   NGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQ       NOV7v   NGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQ       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   EGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGN       NOV7ab   ------NGR-CTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLIDCMDPDCCL       NOV7ac   NGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQ               NOV7a   CNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSAC       NOV7b   N-----------------------------------------------------------       NOV7c   L-----------------------------------------------------------       NOV7d   L-----------------------------------------------------------       NOV7e   D-----------------------------------------------------------       NOV7f   W-----------------------------------------------------------       NOV7g   L-----------------------------------------------------------       NOV7h   EAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDGTI----------------------       NOV7i   ------------------------------------------------------------       NOV7j   EAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDS------------------------       NOV7k   ------------------------------------------------------------       NOV7l   N-----------------------------------------------------------       NOV7m   EAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGECVSGVCHCFPG       NOV7n   ------------------------------------------------------------       NOV7o   G-----------------------------------------------------------       NOV7p   EAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGECVSGVCHCFPG       NOV7q   L-----------------------------------------------------------       NOV7r   N-----------------------------------------------------------       NOV7s   N-----------------------------------------------------------       NOV7t   ------------------------------------------------------------       NOV7u   N-----------------------------------------------------------       NOV7v   N-----------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   G-----------------------------------------------------------       NOV7ab   Q-----------------------------------------------------------       NOV7ac   N-----------------------------------------------------------               NOV7a   QNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIR       NOV7b   --SLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIR       NOV7c   --PGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNL       NOV7d   --PGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNL       NOV7e   --PLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIRGQVVTTDGT       NOV7f   --QCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDP       NOV7g   --PGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNL       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   --SLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIR       NOV7m   FLGADCAKGMCRHFP---------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   --RCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNS       NOV7p   FLGADCAKAACPVLC---------------------------------------------       NOV7q   --PGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNL       NOV7r   --SLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIR       NOV7s   --SLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIR       NOV7t   ------------------------------------------------------------       NOV7u   --SLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIR       NOV7v   --SLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIR       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   --RCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNS       NOV7ab   --SSCQNQPyCRGLPDPQDIISQSLQSPSQQAAKSFYDRISFLIGSDSTHVIPGESPFNS       NOV7ac   --SLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIR               NOV7a   GQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERT       NOV7b   GQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERT       NOV7c   ASTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWS       NOV7d   AYTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWS       NOV7e   PLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERTVWLPWNSFY       NOV7f   LDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIRGQVVTTDGTPLV       NOV7g   AYTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWS       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   GQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERT       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   LLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIRGQV       NOV7p   ------------------------------------------------------------       NOV7q   ASTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWS       NOV7r   GQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERT       NOV7s   GQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERT       NOV7t   ------------------------------------------------------------       NOV7u   GQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERT       NOV7v   GQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERT       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   LLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIRGQV       NOV7ab   LVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTYSLSRFDLIANGGASLTLHF       NOV7ac   GQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERT               NOV7a   VWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPET       NOV7b   VWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPET       NOV7c   LDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAP       NOV7d   LDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRPRSISCPSCNGLAEGNKLLAP       NOV7e   AMDTLVMXTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIEL       NOV7f   GVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFEPAPFMSQERTVWLPWNSFYAMD       NOV7g   LDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAP       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   VWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPET       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   VTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERTVWL       NOV7p   ------------------------------------------------------------       NOV7q   LDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAP       NOV7r   VWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPET       NOV7s   VWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPET       NOV7t   ------------------------------------------------------------       NOV7u   VWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPET       NOV7v   VWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPET       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   VTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFEPAPFMSQERTVWL       NOV7ab   EPAPFMSQERTVWLPWNSFYANDTLVMKTEENSIPSCDLSGFCRLDPIIISSPLSTFFSA       NOV7ac   VWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPET               NOV7a   QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKS       NOV7b   QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKS       NOV7c   VALAVGIDGSLYVGDFNYIRRIFPSRN---------------------------------       NOV7d   VALAVGIDGSLYVGDFNYIRRIFPSRNLEG------------------------------       NOV7e   PGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLAY       NOV7f   TLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVFETQVLHEEIELPGS       NOV7g   VALAVGIDGSLYVGDFNYIRRIFPSRNLEG------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKS       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   PWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSFLSTFFSAAPGQNPIVPETQVL       NOV7p   ------------------------------------------------------------       NOV7q   VALAVGIDGSLYVGDFNYIRRIFPSRNVTSILELRNKEFKHSNNPAHKYYLAVDPVSGSL       NOV7r   QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKS       NOV7s   QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKS       NOV7t   ------------------------------------------------------------       NOV7u   QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKS       NOV7v   QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKS       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   PWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVL       NOV7ab   APGQNPIVPETQVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLM       NOV7ac   QVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKS               NOV7a   FQASPNLASTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDP       NOV7b   FQASPNLASTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDP       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   TFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLD       NOV7f   NVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLAYTFI       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   FQASPNLASTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDP       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   HEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQA       NOV7p   ------------------------------------------------------------       NOV7q   YVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDATLMSPRG       NOV7r   FQASPNLASTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDP       NOV7s   FQASPNLASTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDP       NOV7t   ------------------------------------------------------------       NOV7u   FQASPNLASTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDP       NOV7v   FQASPNLAYTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDP       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   HEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLTRVHLMVAVEGHLFQKSFQA       NOV7ab   VAVEGHLFQKSFQASPNLAYTFIWDKTDAYGQRVYGLSDAVGMFWFQRTALLQGFELDPS       NOV7ac   FQASPNASTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDP               NOV7a   SNLGGWSLDKHHILNVKSGILHKGTGENQFLTQQPAITTSIMGNGRRRSISCPSCNGLAE       NOV7b   SNLGGWSLDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAE       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   KHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVA       NOV7f   WDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHH       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   SNLGGWSLDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAE       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   SPNLASTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNL       NOV7p   ------------------------------------------------------------       NOV7q   IAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVRLEWPTDL       NOV7r   SNLGGWSLDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAE       NOV7s   SNLGGWSLDKHHILNVKSGTLHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAE       NOV7t   ------------------------------------------------------------       NOV7u   SNLGGWSLDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAE       NOV7v   SNLGGWSLDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRPRSISCPSCNGLAE       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   SPNLAYTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNL       NOV7ab   NLGGWSLDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEG       NOV7ac   SNLGGWSLDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAE               NOV7a   GNKLLAPVALAVGIDGSLYVGDFNYIRRIFPSRNVTSILELRNKEFKHSNNPAHKYYLAV       NOV7b   GNKLLAPVALAVGIDGSLYVGDFNYIRRIFPSRNVTSILELRNKEFKHSNNPAHKYYLAV       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   LAVGIDGSLYVGDFNYIRRIFPSRNLEG--------------------------------       NOV7f   ILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAV       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   GNKLLAPVALAVGIDGSLYVGDFNYIRRIFPSRNVTSILELRNKEFKHSNNPAHKYYLAV       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   GGWSLDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNK       NOV7p   ------------------------------------------------------------       NOV7q   AVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSALESASAI       NOV7r   GNKLLAPVALAVGIDGSLYVGDFNYIRRIFPSR1VTSILELRNKEFKHSNNPAHKYYLAV       NOV7s   GNKLLAPVALAVGIDGSLYVGDFNYIRRIFPSRNVTSILELRNKEFKHSNNPAHKYYLAV       NOV7t   ------------------------------------------------------------       NOV7u   GNKLLAPVALAVGIDGSLYVGDFNYIRRIFPSRNVTSILELRNKEFKHSNNPAHKYYLAV       NOV7v   GNKLLAPVALAVGIDGSLYVGDFNYIRRIFPSRN--------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   GGWSLDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNK       NOV7ab   NKLLAPVALAVGIDGSLYVGDFNYIRRIFPSRNVTSILELRRNKEFKHSNNPAHKYYLAV       NOV7ac   GNKLLAPVALAVGIDGSLYVGDFNYIRRIFPSRNVTSILELRNKEFKHSNNPAHKYYLAV               NOV7a   DPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDA       NOV7b   DPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDA       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   GIDGSLYVGDFNYIRRIFPSRNLEG-----------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   DPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDA       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   LLAPVALAVGIDGSLYVGDFNYIRRIFPSRNVTSILELRNKEFKHSNNPAHKYYLAVDPV       NOV7p   ------------------------------------------------------------       NOV7q   AISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSGDDAYATD       NOV7r   DPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDA       NOV7s   DPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDA       NOV7t   ------------------------------------------------------------       NOV7u   DPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDA       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   LLAPVALAVGIDGSLYVGDFNYIRRIFPSRN-----------------------------       NOV7ab   DPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDA       NOV7ac   DPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDA               NOV7a   TLMSPRGIAVDKNGLMYFVDATMIRXVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVR       NOV7b   TLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVR       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   TLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVR       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   SGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDATLM       NOV7p   ------------------------------------------------------------       NOV7q   AILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADG       NOV7r   TLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVR       NOV7s   TLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVR       NOV7t   ------------------------------------------------------------       NOV7u   TLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVR       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   TLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVR       NOV7ac   TLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVR               NOV7a   LEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKIAIHSA       NOV7b   LEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKIAIHSA       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   LEWPTDIAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSA       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   SPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVRLEW       NOV7p   ------------------------------------------------------------       NOV7q   IHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLT       NOV7r   LEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSA       NOV7s   LEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKTAIHSA       NOV7t   ------------------------------------------------------------       NOV7u   LEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRFMHCQVPGIDYSLSKLAIHSA       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   LEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSA       NOV7ac   LEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSA               NOV7a   LESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSG       NOV7b   LESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSG       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   LESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSG       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   PTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSALES       NOV7p   ------------------------------------------------------------       NOV7q   VGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVV       NOV7r   LESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSG       NOV7s   LESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSG       NOV7t   ------------------------------------------------------------       NOV7u   LESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSG       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   LESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSG       NOV7ac   LESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSG               NOV7a   DDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQEL       NOV7b   DDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQEL       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   DDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQEL       NOv7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   ASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSGDDA       NOV7p   ------------------------------------------------------------       NOV7q   TSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMY       NOV7r   DDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQEL       NOV7s   DDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIPAVSKNKPVLNAFNQYEAASPGEQEL       NOV7t   ------------------------------------------------------------       NOV7u   DDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQEL       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   DDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQEL       NOV7ac   DDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQEL               NOV7a   YVFNADGIHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPD       NOV7b   YVFNADGIHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPD       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   YVFNADGIHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPD       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   YATDAILNSPSSLLAVAPDGTIYIADLGNIRIRAVSIKPVLNAFNQYEAASPGEQELYVF       NOV7p   ------------------------------------------------------------       NOV7q   ANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLR       NOV7r   YVFNADGIHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPD       NOV7s   YVFNADGIHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPD       NOV7t   ------------------------------------------------------------       NOV7u   YVFNADGIHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIPRDSSGMPRHLLMPD       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   YVFNADGIHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPD       NOV7ac   YVFNADGIHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPD               NOV7a   NQIITLTVGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNV       NOV7b   NQIITLTVGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNV       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   NQIITLTVGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNV       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   NADGIHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQI       NOV7p   ------------------------------------------------------------       NOV7q   VHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGR       NOV7r   NQIITLTVGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNV       NOV7s   NQIITLTVGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNV       NOV7t   ------------------------------------------------------------       NOV7u   NQIITLTVGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNV       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   NQIITLTVGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYSYDHEGRLTNV       NOV7ac   NQIITLTVGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYDYDNEGRLTNV               NOV7a   TRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNN       NOV7b   TRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVPNSYQLCNN       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   TRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNN       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   ITLTVGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRP       NOV7p   ------------------------------------------------------------       NOV7q   LAGLQRGANSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQRQYIFEYDSSDR       NOV7r   TRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNN       NOV7s   TRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVPNSYQLCNN       NOV7t   ------------------------------------------------------------       NOV7u   TRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTWQDQVRNSYQLCNN       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   TRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNN       NOV7ac   TRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNN               NOV7a   GTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVT       NOV7b   GTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVT       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7l   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   GTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVT       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   TGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVPNSYQLCNNGTL       NOV7p   ------------------------------------------------------------       NOV7q   LLAVTMPSVAPHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLGTGRQVFY       NOV7r   GTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVT       NOV7s   GTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVT       NOV7t   ------------------------------------------------------------       NOV7u   GTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVT       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   GTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVT       NOV7ac   GTLRVMYANGMGISFHSEPNVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVT               NOV7a   IFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNV       NOV7b   IFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNV       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7l   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   IFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNV       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   RVMYANGMGISFHSEPHVIAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFG       NOV7p   ------------------------------------------------------------       NOV7q   KYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFS       NOV7r   IFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNV       NOV7s   IFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNV       NOV7t   ------------------------------------------------------------       NOV7u   IFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNV       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   IFGRKLEVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNV       NOV7ac   IFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNV               NOV7a   SYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQRQYIF       NOV7b   SYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQRQYIF       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   SYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQRQYIF       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   RKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYF       NOV7p   ------------------------------------------------------------       NOV7q   EEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDIN       NOV7r   SYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQRQYIF       NOV7s   SYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQRQYIF       NOV7t   ------------------------------------------------------------       NOV7u   SYFFNGRLAGLQRGANSERTDIDKQGRIVSRNFADGKVWSYSYLDKSMVLLLQSQRQYIF       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   SYFFNGRLAGLQRGAMSERTDIDKQGRIVSRNFADGKVWSYSYLDKMVLLLQSQRQYIFE       NOV7ac   SYFFNGRLAGLQRGAMSERTDIDKQGRIVSPMFADGKVWSYSYLDKSMVLLLQSQRQYIF               NOV7a   EYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLG       NOV7b   EYDSSDRLLAVTMPSVARHSMSTHTSIGYIPNIYNPPESNASVIFDYSDDGRILKTSFLG       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   EYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLG       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   FNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQRQYIFEYD       NOV7p   ------------------------------------------------------------       NOV7q   QIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTK       NOV7r   EYDSSDRLLAVTMPSVARHSMSTHTSIGYIRMIYNPPESNASVIFDYSDDGRILKTSFLG       NOV7s   EYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLG       NOV7t   ------------------------------------------------------------       NOV7u   EYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLG       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   YDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLGT       NOV7ac   EYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLG               NOV7a   TGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVD       NOV7b   TGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVD       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   TGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVD       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   SSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLGTGR       NOV7p   ------------------------------------------------------------       NOV7q   YTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGDV       NOV7r   TGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFScTIRYRKIGPLVD       NOV7s   TGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVD       NOV7t   ------------------------------------------------------------       NOV7u   TGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVD       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   GRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDK       NOV7ac   TGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVD               NOV7a   KQIYRFSEEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFG       NOV7b   KQIYRFSEEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFG       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   KQIYRFSEEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFG       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   QVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQI       NOV7p   ------------------------------------------------------------       NOV7q   QYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGWSVQYRYDGVGRRASYKTNLGHHLQ       NOV7r   KQIYRFSEEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFG       NOV7s   KQIYRFSEEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFG       NOV7t   ------------------------------------------------------------       NOV7u   KQIYRFSEEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFG       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   QIYRFSEEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGV       NOV7ac   KQIYRFSEEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDETSGKVEHFGKFG               NOV7a   VIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLG       NOV7b   VIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLG       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   VIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLG       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   YRFSEEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIY       NOV7p   ------------------------------------------------------------       NOV7q   YFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTGTPLAVFS       NOV7r   VIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLG       NOV7s   VIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLG       NOV7t   ------------------------------------------------------------       NOV7u   VIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLG       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   IYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGP       NOV7ac   VIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLG               NOV7a   PYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLFLR       NOV7b   PYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLFLR       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   PYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDR       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   YDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYA       NOV7p   ------------------------------------------------------------       NOV7q   INGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSP       NOV7r   PYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDR       NOV7s   PYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDR       NOV7t   ------------------------------------------------------------       NOV7u   PYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLPDR       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   YANTTKYTYDYDGDGQLQSVPAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDR       NOV7ac   PYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDR               NOV7a   ITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGwSVQYRYDGVGRRASYKT       NOV7b   ITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGwSVQYRYDGVGRRAsYKT       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   ITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGWSVQYRYDGVGRRASYKT       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   NTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITR       NOV7p   ------------------------------------------------------------       NOV7q   DYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNIIPGFPRA       NOV7r   ITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGWSVQYRYDGVGRRASYKT       NOV7s   ITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGWSVQYRYDGVGRRASYKT       NOV7t   ------------------------------------------------------------       NOV7u   ITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGWSVQYRYDGVGRRASYKT       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   ITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGWSVQYRYDGVGRRASYKT       NOV7ac   ITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGWSVQYRYDGVGRRASYKT               NOV7a   NLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTG       NOV7b   NLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTG       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   NLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTG       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   LGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTPAYNKASGWSVQYRYDGVGRRASYKTNLG       NOV7p   ------------------------------------------------------------       NOV7q   KMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASIREKAGHW       NOV7r   NLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTG       NOV7s   NLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTG       NOV7t   ------------------------------------------------------------       NOV7u   NLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTG       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   NLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTG       NOV7ac   NLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTG               NOV7a   TPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVL       NOV7b   TPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVL       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   TPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVL       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   HHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTGTPL       NOV7p   ------------------------------------------------------------       NOV7q   FATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKDTHY       NOV7r   TPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVL       NOV7s   TPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVL       NOV7t   ------------------------------------------------------------       NOV7u   TPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVL       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   TPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVL       NOV7ac   TPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVL               NOV7a   AGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNI       NOV7b   AGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNI       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   AGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNI       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   AVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGR       NOV7p   ------------------------------------------------------------       NOV7q   FVKIGSADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYSTLLLSIR       NOV7r   AGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNI       NOV7s   AGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNI       NOV7t   ------------------------------------------------------------       NOV7u   AGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNI       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   AGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNI       NOV7ac   AGRWTSPDYTNWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNI               NOV7a   IPGFPRAXMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASI       NOV7b   IPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASI       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   IPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASI       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   WTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNIIPG       NOV7p   ------------------------------------------------------------       NOV7q   YGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQ       NOV7r   IPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASI       NOV7s   IPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASI       NOV7t   ------------------------------------------------------------       NOV7u   IPGFPRAXMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASI       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   IPGFPRAKMYFVPPPYELSESQASENGQLITGAHQTTERHNQAFMALEGQVITKKLHASI       NOV7ac   IPGFPRAKNYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASI               NOV7a   REKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSI       NOV7b   REKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSI       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   REKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSI       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   FPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASIREK       NOV7p   ------------------------------------------------------------       NOV7q   GYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR--------------------------       NOV7r   REKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSI       NOV7s   REKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSI       NOV7t   ------------------------------------------------------------       NOV7u   REKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSI       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   REKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSI       NOV7ac   REKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSI               NOV7a   EGKDTHYFVKIGSADGDLVTLGTTIGRYVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYS       NOV7b   EGKDTHYFVKIGSADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYS       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       Nov7l   EGKDTHYFVKIGSADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYS       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   AGHWFATTTPITGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGK       NOV7p   ------------------------------------------------------------       NOV7q   ------------------------------------------------------------       NOV7r   EGKDTHYFVKIGSADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYS       NOV7s   EGKDTHYFVKIGSADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYS       NOV7t   ------------------------------------------------------------       NOV7u   EGKDTHYFVKIGSADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYS       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   EGKDTHYFVKIGSADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYS       NOV7ac   EGKDTHYFVKIGSADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYS               NOV7a   TLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQL       NOV7b   TLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQL       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       Nov7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   TLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQL       NOV7m   ------------------------------------------------------------       NOV7n   ------------------------------------------------------------       NOV7o   DTHYFVKIGSADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYSTLL       NOV7p   ------------------------------------------------------------       NOV7q   ------------------------------------------------------------       NOV7r   TLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQL       NOV7s   TLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQL       NOV7t   ------------------------------------------------------------       NOV7u   TLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQL       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   TLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKAPDGREGSRLWTEGEKQQL       NOV7ac   TLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQL               NOV7a   LSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR-------------------       NOV7b   LSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR-------------------       NOV7c   ------------------------------------------------------------       NOV7d   ------------------------------------------------------------       NOV7e   ------------------------------------------------------------       NOV7f   ------------------------------------------------------------       NOV7g   ------------------------------------------------------------       NOV7h   ------------------------------------------------------------       NOV7i   ------------------------------------------------------------       NOV7j   ------------------------------------------------------------       NOV7k   ------------------------------------------------------------       NOV7l   LSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR-------------------       NOV7m   ------------------------------------------------------------       NOV7o   LSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLST       NOV7p   ------------------------------------------------------------       NOV7q   ------------------------------------------------------------       NOV7r   LSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR-------------------       NOV7s   LSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR-------------------       NOV7t   ------------------------------------------------------------       NOV7u   LSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR-------------------       NOV7v   ------------------------------------------------------------       NOV7w   ------------------------------------------------------------       NOV7x   ------------------------------------------------------------       NOV7y   ------------------------------------------------------------       NOV7z   ------------------------------------------------------------       NOV7aa   ------------------------------------------------------------       NOV7ab   LSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNENGKR-------------------       NOV7ac   LSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR-------------------               NOV7a   --------------------------------------       NOV7b   --------------------------------------       NOV7c   --------------------------------------       NOV7d   --------------------------------------       NOV7e   --------------------------------------       NOV7f   --------------------------------------       NOV7g   --------------------------------------       NOV7h   --------------------------------------       NOV7i   --------------------------------------       NOV7j   --------------------------------------       NOV7k   --------------------------------------       NOV7l   --------------------------------------       NOV7m   --------------------------------------       NOV7n   --------------------------------------       NOV7o   GRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR       NOV7p   --------------------------------------       NOV7q   --------------------------------------       NOV7r   --------------------------------------       NOV7s   --------------------------------------       NOV7t   --------------------------------------       NOV7u   --------------------------------------       NOV7v   --------------------------------------       NOV7w   --------------------------------------       NOV7x   --------------------------------------       NOV7y   --------------------------------------       NOV7z   --------------------------------------       NOV7aa   --------------------------------------       NOV7ab   --------------------------------------       NOV7ac   --------------------------------------               NOV7a   (SEQ ID NO: 114)       NOV7b   (SEQ ID NO: 116)       NOV7c   (SEQ ID NO: 118)       NOV7d   (SEQ ID NO: 120)       NOV7e   (SEQ ID NO: 122)       NOV7f   (SEQ ID NO: 124)       NOV7g   (SEQ ID NO: 126)       NOV7h   (SEQ ID NO: 128)       NOV7i   (SEQ ID NO: 130)       NOV7j   (SEQ ID NO: 132)       NOV7k   (SEQ ID NO: 134)       NOV7l   (SEQ ID NO: 136)       NOV7m   (SEQ ID NO: 138)       NOV7n   (SEQ ID NO: 140)       NOV7o   (SEQ ID NO: 142)       NOV7p   (SEQ ID NO: 144)       NOV7q   (SEQ ID NO: 146)       NOV7r   (SEQ ID NO: 148)       NOV7s   (SEQ ID NO: 150)       NOV7t   (SEQ ID NO: 152)       NOV7u   (SEQ ID NO: 154)       NOV7v   (SEQ ID NO: 156)       NOV7w   (SEQ ID NO: 158)       NOV7x   (SEQ ID NO: 160)       NOV7y   (SEQ ID NO: 162)       NOV7z   (SEQ ID NO: 164)       NOV7aa   (SEQ ID NO: 166)       NOV7ab   (SEQ ID NO: 168)       NOV7ac   (SEQ ID NO: 170)                  
 
      Further analysis of the NOV7a protein yielded the following properties shown in Table 7C.  
               TABLE 7C                       Protein Sequence Properties NOV7a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 9; pos. chg 4; neg. chg 2           H-region:   length 3; peak value −8.37           PSG score:   −12.77                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −14.20           possible cleavage site: between 32 and 33                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 2           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 380-396               −11.73                             PERIPHERAL   Likelihood = 3.39 (at 982)                         ALOM score: −11.73 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 387           Charge difference: −6.0 C(0.0)-N(6.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 2 (cytoplasmic tail 1 to 380)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   3.46           Hyd Moment(95):   5.35   G content:   0           D/E content:   2   S/T content:   0                         Score: −7.50       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: RRHR (3) at 6           pat7: PRERRSI (5) at 483           bipartite: RKEQIKGKVTIFGRKLR at 1712           content of basic residues: 9.7%           NLS Score: 0.64       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         KKXX-like motif in the C-terminus: EMGK                 SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: found                         LL at 179           LL at 200           LL at 224           LL at 351                 checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 70.6       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues•                 Final Results (k = 9/23):                         43.5%: nuclear           21.7%: mitochondrial           13.0%: cytoplasmic            8.7%: Golgi            4.3%: plasma membrane            4.3%: extracellular, including cell wall            4.3%: peroxisomal                 &gt;&gt; prediction for CG50426-17 is nuc (k = 23)                  
 
      A search of the NOV7a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 7D.  
               TABLE 7D                          Geneseq Results for NOV7a                                         NOV7a                       Residues/   Identities/       Geneseq   Protein/Organism/Length   Match   Similarities for the   Expect       Identifier   [Patent #, Date]   Residues   Matched Region   Value               AAU08681   Human FCTR3f polypeptide   1 . . . 2662   2620/2728 (96%)   0.0           sequence -  Homo sapiens , 2724 aa.   1 . . . 2724   2628/2728 (96%)           [WO200166747-A2, 13-SEP-2001]       AAU08680   Human FCTR3b polypeptide   1 . . . 2662   2620/2737 (95%)   0.0           sequence -  Homo sapiens , 2733 aa.   1 . . . 2733   2628/2737 (95%)           [WO200166747-A2, 13-SEP-2001]       ABP53587   Human NOV15b protein SEQ ID   1 . . . 2662   1780/2799 (63%)   0.0           NO: 38 -  Homo sapiens , 2721 aa.   1 . . . 2721   2156/2799 (76%)           [WO200262999-A2, 15-AUG-2002]       ABP53586   Human NOV15a protein SEQ ID   1 . . . 2662   1779/2803 (63%)   0.0           NO: 36 -  Homo sapiens , 2725 aa.   1 . . . 2725   2155/2803 (76%)           [WO200262999-A2, 15-AUG-2002]       ABP53589   Human NOV15d protein SEQ ID   239 . . . 2662    1689/2546 (66%)   0.0           NO: 42 -  Homo sapiens , 2613 aa.   80 . . . 2613    2035/2546 (79%)           [WO200262999-A2, 15-AUG-2002]                  
 
      In a BLAST search of public sequence databases, the NOV7a protein was found to have homology to the proteins shown in the BLASTP data in Table 7E.  
               TABLE 7E                          Public BLASTP Results for NOV7a                                         NOV7a               Protein       Residues/   Identities/       Accession       Match   Similarities for the   Expect       Number   Protein/Organism/Length   Residues   Matched Portion   Value               CAC88676   Sequence 12 from Patent   1 . . . 2662   2620/2728 (96%)   0.0           WO0166747 -  Homo sapiens     1 . . . 2724   2628/2728 (96%)           (Human), 2724 aa.       CAC88675   Sequence 7 from Patent   1 . . . 2662   2620/2737 (95%)   0.0           WO0166747 -  Homo sapiens     1 . . . 2733   2628/2737 (95%)           (Human), 2733 aa.       Q9WTS5   Ten-m2 -  Mus musculus  (Mouse),   1 . . . 2662   2582/2768 (93%)   0.0           2764 aa.   1 . . . 2764   2611/2768 (94%)       Q9R1K2   Neurestin alpha -  Rattus     1 . . . 2662   2574/2769 (92%)   0.0             norvegicus  (Rat), 2765 aa.   1 . . . 2765   2610/2769 (93%)       Q9ULU2   KIAA1127 protein -  Homo sapiens     590 . . . 2662    2029/2148 (94%)   0.0           (Human), 2144 aa (fragment).   1 . . . 2144   2037/2148 (94%)                  
 
      PFam analysis predicts that the NOV7a protein contains the domains shown in the Table 7F.  
               TABLE 7F                          Domain Analysis of NOV7a                                             Identities/                       Similarities           Pfam   NOV7a   for the   Expect           Domain   Match Region   Matched Region   Value                                                 EGF   599 . . . 626   10/47 (21%)   0.44                   20/47 (43%)           EGF   631 . . . 658   13/47 (28%)   0.0037                   20/47 (43%)           EGF   698 . . . 728    9/47 (19%)   0.019                   24/47 (51%)           NHL   1302 . . . 1337   12/36 (33%)   0.36                   27/36 (75%)           NHL   1431 . . . 1458   12/29 (41%)   0.00074                   23/29 (79%)                      
 
     Example 8.  
      The NOV8 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 8A.  
               TABLE 8A                       NOV8 Sequence Analysis                                                NOV8a, CG50646-04   SEQ ID NO: 177   11158 bp                             DNA Sequence   ORF Start: ATG at 77   ORF Stop: TAA at 10787                             CAATTGGTCTAGGGTCTCCCCCATTGGAATATCCATCAGTGATGAGAAATACAACGTTTGTTGAGTTT           TCTCTAGCATGAGAAGAATTTGCGCGGCTTGCTGGGGTCTGGCGCTCGTTTCGGGCTGGGCGACCTTT       CAGCAGATGTCCCCGTCGCGCAATTTCAGCTTCCGCCTCTTCCCCGAGACCGCGCCCGGGGCCCCCGG       GAGTATCCCCGCGCCGCCCGCTCCTGGCGACGAAGCGGCGGGGAGCAGAGTGGAGCGGCTGGGCCAGG       CGTTCCGCGTGCGGCTGCTGCGGGAGCTCAGCGAGCGCCTGGAGCTTGTCTTCCTGGTGGATGATTCG       TCCAGCGTGGGCGAAGTCAACTTCCGCAGCGAGCTCATGTTCGTCCGCAAGCTGCTGTCCGACTTCCC       CGTGGTGCCCACGGCCACGCGCGTGGCCATCGTGACCTTCTCGTCCAAGAACTACGTGGTGCCGCGCG       TCGATTACATCTCCACCCGCCGCGCGCGCCAGCACAAGTGCGCGCTGCTCCTCCAAGAGATCCCTGCC       ATCTCCTACCGAGGTGGCGGCACCTACACCAAGGGCGCCTTCCAGCAAGCCGCGCAAATTCTTCTTCA       TGCTAGAGAAAACTCAACAAAAGTTGTATTTCTCATCACTGATGGATATTCCAATGGGGGAGACCCTA       GACCAATTGCAGCGTCACTGCGAGATTCAGGAGTGGAGATCTTCACTTTTGGCATATGGCAAGGGAAC       ATTCGAGAGCTGAATGACATGGCTTCCACCCCAAAGGAGGAGCACTGTTACCTGCTACACAGTTTTGA       AGAATTTGAGGCTTTAGTCGCCCTCTGTCATATGTTATTTGTAGATCTACCTTCTGGGAGTTTTATTC       AAGATGATATGGTCCACTGCTCATATCTTTGTGATGAAGGCAAGGACTGCTGTGACCGAATGGGAAGC       TGCAAATGTGGGAAACACACAGGCCATTTTGAGTGCATCTGTGAAAAGGGGTATAACGGGAAAGGTCT       GCAGTATGACTGCACAGTTTGCCCATCGGGGACATACAAACCTGAAGGCTCACCAGGAGGAATCAGCA       TGCAGAGAGGGATACAGGGCATCTGGCCAGACCTGTGAAGTTGTCCACTGCCCTGCCCTGAAGCCTCC       CGAAAATGGTTACTTTATCCAAAACACTTGCAACAACCACTTCAATGCAGCCTGTGGGGTCCGATGTC       ACCCTGGATTTGATCTTGTGGGAAGCAGCATCATCTTATGTCTACCCAATGGTTTGTGGTCCGGTTCA       GAGAGCTACTGCAGAGTAAGAACATGTCCTCATCTCCGCCAGCCGAAACATGGCCACATCAGCTGTTC       TACAAGGGAAATGTTATATAAGACAACATGTTTGGTTGCCTGTGATGAAGGGTACAGGCTAGAAGGCA       GTGATAAGCTTACTTGTCAAGGAAACAGCCAGTGGGATGGGCCAGAACCCCGGTGTGTGGAGCGCCAC       TGTTCCACCTTTCAGATGCCCAAAGATGTCATCATATCCCCCCACAACTGTGGCAAGCAGCCAGCCAA       ATTTGGGACGATCTGCTATGTAAGTTGCCGCCAAGGGTTCATTTTATCTGGAGTCAAAGAAATGCTGA       GATGTACCACTTCTGGAAAATGGAATGTCGGAGTTCAGGCAGCTGTGTGTAAAGACGTGGAGGCTCCT       CAAATCAACTGTCCTAAGGACATAGAGGCTAAGACTCTGGAACAGCAAGATTCTGCCAATGTTACCTG       GCAGATTCCAACAGCTAAAGACAACTCTGGTGAAAAGGTGTCAGTCCACGTTCATCCAGCTTTCACCC       CACCTTACCTTTTCCCAATTGGAGATGTTGCTATCGTATACACGGCAACTGACCTATCCGGCAACCAG       GCCAGCTGCATTTTCCATATCAAGGTTATTGATGCAGAACCACCTGTCATAGACTGGTGCAGATCTCC       ACCTCCCGTCCAGGTCTCGGAGAAGGTACATGCCGCAAGCTGGGATGAGCCTCAGTTCTCAGACAACT       CAGGTGCTGAATTGGTCATTACCAGAAGTCATACACAAGGAGACCTTTTCCCTCAAGGGGAGACTATA       GTACAGTATACAGCCACTGACCCCTCAGGCAATAACAGGACATGTGATATCCATATTGTCATAAAAGG       TTCTCCCTGTGAAATTCCATTCACACCTGTAAATGGGGATTTTATATGCACTCCAGATAATACTGGAG       TCAACTGTACATTAACTTGCTTGGAGGGCTATGATTTCACAGAAGGGTCTACTGACAAGTATTATTGT       GCTTATGAAGATGGCGTCTGGAAACCAACATATACCACTGAATGGCCAGACTGTGCCAGTAAGCGTTT       TGCAAACCACGGGTTCAAGTCCTTTGAGATGTTCTACAAAGCAGCTCGTTGTGATGACACAGATCTGA       TGAAGAAGTTTTCTGAAGCATTTGAGACGACCCTGGGAAAAATGGTCCCATCATTTTGTAGTGATGCA       GAGGACATTGACTGCAGACTGGAGGAGAACCTGACCAAAAAATATTGCCTAGAATATAATTATGACTA       TGAAAATGGCTTTGCAATTGGTCCAGGTGGCTGGGGTGCAGCTAATAGGCTGGATTACTCTTACGATG       ACTTCCTGGACACTGTGCAAGAAACAGCCACAAGCATCGGCAATGCCAAGTCCTCACGGATTAAAAGA       AGTGCCCCATTATCTGACTATAAAATTAAGTTAATTTTTAACATCACAGCTAGTGTGCCATTACCCGA       TGAAAGAAATGATACCCTTGAATGGGAAAATCAGCAACGACTCCTTCAGACATTGGAAACTATCACAA       GCCGACAGCAATTCATTAGAAACAAAAAAGGCTTCCCCCTTCTGCAGACCAGGCTCAGTGCTGAGAGG       GGATCGGATCCTATCAAGATGAAGAAGGGCAACTTGAGTGCAAGCTTTGCCCCTCTGGGATGTACACG       GAATATATCCATTCAAGAAACATCTCTGATTGTAAAGCTCAGTGTAAACAAGGCACCTACTCATACAG       TGGACTTGAGACTTGTGAATCGTGTCCACTGGGCACTTATCAGCCAAAATTTGGTTCCCGGAGCTGCC       TCTCGTGTCCAGAAAACACCTCAACTGTGAAAAGAGGAGCCGTGAACATTTCTGCATGTGGAGTTCCT       TGTCCAGAAGGAAAATTCTCGCGTTCTGGGTTAATGCCCTGTCACCCATGTCCTCGTGACTATTACCA       ACCTAATGCAGGGAAGGCCTTCTGCCTGGCCTGTCCCTTTTATGGAACTACCCCATTCGCTGGTTCCA       GATCCATCACAGAATGTTCAAGTTTTAGTTCAACTTTCTCAGCGGCAGAGGAAAGTGTGGTGCCCCCT       GCCTCTCTTGGACATATTAAAAAGAGGCATGAAATCAGCAGTCAGGCAAGTCATGAATGCTTCTTTAA       ATACAGGTTTAAAGTGTGAAACAGACATCGATGAGTGCAGCCCACTGCCTTGCCTCAACAATGGAGTT       TGTAAAGACCTAGTTGGGGAATTCATTTGTGAGTGCCCATCAGGTTACACAGGTAAGCACTGTGAATT       GAACATCAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTCAT       ACAGTTGTAAATGTCAGCCAGGATTTTCAGGCAAAAGGTGTGAAACAGGTATGTATCAACTCAGTGTT       ATTAATAACCTTAATAATGCAGTCTGTGAAGACCAGGTTGGGGGATTCTTGTGCAAATGCCCACCTGG       CCTGTAAAGACGGTGCCAATAGCTTCAGGTGCCTGTGTGCAGCTGGCTTCACAGGATCACACTGTGAA       TTGAACATCAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTC       ACCTGGATTTTGAAGTTTCTGGCATCTATGGATATGTCATGCTAGATGGCATGCTCCCATCTCTCCAT       GCTCTAACCTGTACCTTCTGGATGAAATCCTCTGACGACATGAACTATGGAACACCAATCTCCTATGC       AGTTGATAACGGCAGCGACAATACCTTGCTCCTGACTGATTATAACGGGTGGGTTCTTTATGTGAATG       ACAAGTACTGGTGGAGCCTGGAGGGTCTATATAAATGGGGAATTATCTGACGGTGGTACTGGCCTCTC       CATTGGCAAAGCCATACCTGGTGGCGGTGCATTAGTTCTTGGGCAAGAGCAAGACAAAAAAGGAGAGG       GGTTCAACCCGGCTGAGTCTTTTGTGGGCTCCATAAGCCAGCTCAACCTCTGGGACTATGTCCTGTCT       CCACAGCAGGTGAAGTCACTGGCTACCTCCTGCCCAGAGGAACTCAGTAAAGGAAACGTGTTAGCATG       GTCAATCTGTTCTGTGAACCAGGCTTCCAGCTGGTCGGGAACCCTGTGCAGTACTGTCTGAATCAAGG       ACAGTGGACACAACCACTCCCCCACTGTGAACGCATTCGCTGTGGGGTGCCACCTCCTTTGGAGAATG       CTATTGGGTGACTCAAGGATGTTCTGTACAGATAATGGGAGCTGGAACGGCGTTTCACCATCCTGCTT       AGATGTCGATGAGTGTGCAGTTGGATCAGATTGTAGTGAGCATGCTTCTTGCCTGAACGTAGATGGAT       CCTACATATGTTCATGTGTCCCACCGTACACAGGAGATGGGAAAAACTGTGCAGAACCTATAAAATGT       AAGGCTCCAGGAAATCCGGAAAATGGCCACTCCTCAGGTGAGATTTATACAGTAGGTGCCGAAGTCAC       ATTTTCGTGTCAGGAAGGATACCAGTTGATGGGAGTAACCAAAATCACATGTTTGGAGTCTGGAGAAT       GGAATCATCTAATACCATATTGTAAAGCTGTTTCATGTGGTAAACCGGCTATTCCAGAAAATGGTTGC       ATTGAGGAGTTAGCATTTACTTTTGGCAGCAAAGTGACATATAGGTGTAATAAAGGATATACTCTGGC       CGGTGATAAAGAATCATCCTGTCTTGCTAACAGTTCTTGGAGTCATTCCCCTCCTGTGTGTGAACCAG       TGAAGTGTTCTAGTCCGGAAAATATAAATAATGGAAAATATATTTTGAGTGGGCTTACCTACCTTTCT       ACTGCATCATATTCATGCGATACAGGATACAGCTTACAGGGCCCTTCCATTATTGAATGCACGGCTTC       TGGCATCTGGGACAGAGCGCCACCTGCCTGTCACCTCGTCTTCTGTGGAGAACCACCTGCCATCAAAG       ATGCTGTCATTACGGGGAATAACTTCACTTTCAGGAACACCGTCACTTACACTTGCAAAGAAGGCTAT       ACTCTTGCTGGTCTTGACACCATTGAATGCCTGGCCGACGGCAAGTGGAGTAGAAGTGACCAGCAGTG       CCTGGCTGTCTCCTGTGATGAGCCACCCATTGTGGACCACGCCTCTCCAGAGACTGCCCATCGGCTCT       TTGGAGACATTGCATTCTACTACTGCTCTGATGGTTACAGCCTAGCAGACAATTCCCAGCTTCTCTGC       AATGCCCAGGGCAAGTGGGTACCCCCAGAAGGTCAAGACATGCCCCGTTGTATAGCTCATTTCTGTGA       AAAACCTCCATCGGTTTCCTATAGCATCTTGGAATCTGTGAGCAAAGCAAAATTTGCAGCTGGCTCAG       TTGTGAGCTTTAAATGCATGGAAGGCTTTGTACTGAACACCTCAGCAAAGATTGAATGTATGAGAGGT       GGGCAGTGGAACCCTTCCCCCATGTCCATCCAGTGCATCCCTGTGCGGTGTGGAGAGCCACCAAGCAT       CATGAATGGCTATGCAAGTGGATCAAACTACAGTTTTGGAGCCATGGTGGCTTACAGCTGCAACAAGG       GGTTCTACATCAAAGGGGAAAAGAAGAGCACCTGCGAAGCCACAGGGCAGTGGAGTAGTCCTATACCG       ACGTGCCACCCGGTATCTTGTGGTGAACCACCTAAGGTTGAGAATGGCTTTCTGGAGCATACAACTGG       CAGGATCTTTGAGAGTGAAGTGAGGTATCAGTGTAACCCGGGCTATAAGTCAGTCGGAAGTCCTGTAT       TTGTCTGCCAAGCCAATCGCCACTGGCACAGTGAATCCCCTCTGATGTGTGTTCCTCTCGACTGTGGA       AAACCTCCCCCGATCCAGAATGGCTTCATGAAAGGAGAAAACTTTGAAGTAGGGTCCAAGGTTCAGTT       TTTCTGTAATGAGGGTTATGAGCTTGTTGGTGACAGTTCTTGGACATGTCAGAAATCTGGCAAATGGA       ATAAGAAGTCAAATCCAAAGTGCATGCCTGCCAAGTGCCCAGAGCCGCCCCTCTTGGAAAACCAGCTA       GTATTAAAGGAGTTGACCACCGAGGTAGGAGTTGTGACATTTTCCTGTAAAGAAGGGCATGTCCTGCA       AGGCCCCTCTGTCCTGAAATGCTTGCCATCCCAGCAATGGAATGACTCTTTCCCTGTTTGTAAGATTG       TTCTTTGTACCCCACCTCCCCTAATTTCCTTTGGTGTCCCCATTCCTTCTTCTGCTCTTCATTTTGGA       AGTACTGTCAAGTATTCTTGTGTAGGTGGGTTTTTCCTAAGAGGAAATTCTACCACCCTCTGCCAACC       TGATGGCACCTGGAGCTCTCCACTGCCAGAATGTGTTCCAGTAGAATGTCCCCAACCTGAGGAAATCC       CCAATGGAATCATTGATGTGCAAGGCCTTGCCTATCTCAGCACAGCTCTCTATACCTGCAAGCCAGGC       TTTGAATTGGTGGGAAATACTACCACCCTTTGTGGAGAAAATGGTCACTGGCTTGGAGGAAAACCAAC       ATGTAAAGCCATTGAGTGCCTGAAACCCAAGGAGATTTTGAATGGCAAATTCTCTTACACGGACCTAC       ACTATGGACAGACCGTTACCTACTCTTGCAACCGAGGCTTTCGGCTCGAAGGTCCCAGTGCCTTGACC       TGTTTAGAGACAGGTGATTGGGATGTAGATGCCCCATCTTGCAATGCCATCCACTGTGATTCCCCACA       ACCCATTGAAAATGGTTTTGTAGAAGGTGCAGATTACAGCTATGGTGCCATAATCATCTACAGTTGCT       TCCCTGGGTTTCAGGTGGCTGGTCATGCCATGCAGACCTGTGAAGAGTCAGGATGGTCAAGTTCCATC       CCAACATGTATGCCAATAGACTGTGGCCTCCCTCCTCATATAGATTTTGGAGACTGTACTAAACTCAA       AGATGACCAGGGATATTTTGAGCAAGAAGACGACATGATGGAAGTTCCATATGTGACTCCTCACCCTC       CTTATCATTTGGGAGCAGTGGCTAAAACCTGGGAAAATACAAAGGAGTCTCCTGCTACACATTCATCA       AACTTTCTGTATGGTACCATGGTTTCATACACCTGTAATCCAGGATATGAACTTCTGGGGAACCCTGT       GCTGATCTGCCAGGAAGATGGAACTTGGAATGGCAGTGCACCATCCTGCATTTCAATTGAATGTGACT       TGCCTACTGCTCCTGAAAATGGCTTTTTGCGTTTTACAGAGACTAGCATGGGAAGTGCTGTGCAGTAT       AGCTGTAAACCTGGACACATTCTAGCAGGCTCTGACTTAAGGCTTTGTCTAGAGAATAGAAAGTGGAG       AAGGAAGCAACTACACATACCTGAGCACGTTGTACTATGAGTGTGACCCCGGATATGTGCTGAATGGC       CTGCAGTTCACCCCCAGTCTCAGCCAATGGCCAGGTGAGAGGAGACGAGTACACATTCCAAAAAGAGA       TTGAATACACTTGCAATGAAGGGTTCTTGCTTGAGGGAGCCAGGAGTCGGGTTTGTCTTGCCAATGGA       AGTTGGAGTGGAGCCACTCCCGACTGTGTGCCTGTCAGATGTGCCACCCCGCCACAACTGGCCAATGG       GGTGACGGAAGGCCTGGACTATGGCTTCATGAAGGAAGTAACATTCCACTGTCACGAGGGCTACATCT       TGCACGGTGCTCCAAAACTCACCTGTCAGTCAGATGGCAACTGGGATGCAGAGATTCCTCTCTGTAAA       CCAGTCAACTGTGGACCTCCTGAAGATCTTGCCCATGGTTTCCCTAATGGTTTTTCCTTTATTCATGG       GGGCCATATACAGTATCAGTGCTTTCCTGGTTATAAGCTCCATGGAAATTCATCAAGAAGGTGCCTCT       CCAATGGCTCCTGGAGTGGCAGCTCACCTTCCTGCCTGCCTTGCAGATGTTCCACACCAGTAATTGAA       TATGGAACTGTCAATGGGACAGATTTTGACTGTGGAAAGGCAGCCCGGATTCAGTGCTTCAAAGGCTT       GTGAACACACTTCTTGTGGTTCTCTTCCAATGATACCAAATGCGTTCATCAGTGAGACCAGCTCTTGG       AAGGAAAATGTGATAACTTACAGCTGCAGGTCTGGATATGTCATACAAGGCAGTTCAGATCTGATTTG       TACAGAGAAAGGGGTATGGAGCCAGCCTTATCCAGTCTGTGAGCCCTTGTCCTGTGGGTCCCCACCGT       CTGTCGCCAATGCAGTGGCAACTGGAGAGGCACACACCTATGAAAGTGAAGTGAAACTCAGATGTCTG       GAAGGTTATACGATGGATACAGATACAGATACATTCACCTGTCAGAAAGATGGTCGCTGGTTCCCTGA       GAGAATCTCCTGCAGTCCTAAAAAATGTCCTCTCCCGGAAAACATAACACATATACTTGTACATGGGG       ACGATTTCAGTGTGAATAGGCAAGTTTCTGTGTCATGTGCAGAAGGGTATACCTTTGAGGGAGTTAAC       ATATCAGTATGTCAGCTTGATGGAACCTGGGAGCCACCATTCTCCGATGAATCTTGCAGTCCAGTTTC       TTGTGGGAAACCTGAAAGTCCAGAACATGGATTTGTGGTTGGCAGTAAATACACCTTTGAAAGCACAA       TTATTTATCAGTGTGAGCCTGGCTATGAACTAGAGGGGAACAGGGAACGTGTCTGCCAGGAGAACAGA       CAGTGGAGTGGAGGGGTGGCAATATGCAAAGAGACCAGGTGTGAAACTCCACTTGAATTTCTCAATGG       GAAAGCTGACATTGAAAACAGGACGACTGGACCCAACGTGGTATATTCCTGCAACAGAGGCTACAGTC       TTGAAGGGCCATCTGAGGCACACTGCACAGAAAATGGAACCTGGAGCCACCCAGTCCCTCTCTGCAAA       TGATCAGAATGTGTCCATCAAATGTAGGGAAGGTTTTCTGCTGCAGGGCCACGGCATCATTACCTGCA       GTAGAAAATGCAATTGCTCGAGGCGTACATTATCAATATGGAGACATGATCACCTACTCATGTTACAG       TGGATACATGTTGGAGGGTTTCCTGAGGAGTGTTTGTTTAGAAAATGGAACATGGACATCACCTCCTA       TTTGCAGAGCTGTCTGTCGATTTCCATGTCAGAATGGGGGCATCTGCCAACGCCCAAATGCTTGTTCC       TGTCCAGAGGGCTGGATGGGGCGCCTCTGTGAAGAACCAATCTGCATTCTTCCCTGTCTGAACGGAGG       TCGCTGTGTGGCCCCTTACCAGTGTGACTGCCCGCCTGGCTGGACGGGGTCTCGCTGTCATACAGCTG       TTTGCCAGTCTCCCTGCTTAAATGGTGGAAAATGTGTAAGACCAAACCGATGTCACTGTCTTTCTTCT       TGGACGGGACATAACTGTTCCAGGAAAAGGAGGACTGGGTTTTAACCACTGCACGACCATCTGGCTCT       CCCAAAAGCAGGATCATCTCTCCTCGGTAGTGCCTGGGCATCCTGGAACTTATGCAAAGAAAGTCCAA       CATGGTGCTGGGTCTTGTTTAGTAAACTTGTTACTTGGGGTTACTTTTTTTATTTTGTGATATATTTT       GTTATTCCTTGTGACATACTTTCTTACATGTTTCCATTTTTAAATATGCCTGTATTTTCTATATAAAA       ATTATATTAAATAGATGCTGCTCTACCCTCACAAAATGTACATATTCTGCTGTCTATTGGGAAAGTTC       CTGGTACACATTTTTATTCAGTTACTTAAAATGATTTTTCCATTAAAGTATATTTTGCTACTAAATAA       AAAAAA                                         NOV8a CG50646-04                                     Protein sequence   SEQ ID NO: 178   357O aa   MW at 390012.5kD                             MRRICAACWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRVERLGQAFR           VRLLRELSERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAILVTFSSKNYVVPRVDY       ISTRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPI       AASLRDSGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALVALCHMLFVDLPSGSFIQDD       MVHCSYLCDEGKDCCDRMGSCKCGKHTGHFECICEKGYNGKGLQYDCTVCPSGTYKPEGSPGGISSCI       PCPDENHTSPPGSTSPEDCVCREGYRASGQTCEVVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPG       FDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK       LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCT       TSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEKVSVHVHPAFTPPY       LFPIGDVAIVYTATDLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASSWEPQFSDNSGA       ELVITRSHTQGDLFPQGETIVQYTATDPSGNNRTCDIHIVIKGSPCEIPFTPVNGDFICTPDNTGVNC       TLTCLEGYDFTEGSTDKYYCAYEDGVWKPTYTTEWPDCASKRFANHGFKSFEMFYKAARCDDTDLMKK       FSEAFETTLGKMVPSFCSDAEDIDCRLEENLTKKYCLEYNYDYENGFAIGPGGWGAANRLDYSYDDFL       DTVQETATSIGNAKSSRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKL       KRTLNKDPMYSFQLASEILIADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRIG       SYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSC       PENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSI       TECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQASHECFFNPCHNSGTCQQLGRGYVCLCPLGYTG       LKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGKHCELNINECQSNPCRNQATCVDELNSYSC       KCQPGFSGKRCETGMYQLSVINNLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCK       DGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLD       FEVSGIYGYVMLDGMLPSLHALTCTFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGRE       KITNCPSVNDGRWHHIAITWTSTGGAWRVYINGELSDGGTGLSIGKAIPGGGALVLGQEQDKKGEGFN       PAESFVGSISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPR       LGGSVPHLRTASEDLKPGSKVNLFCEPGFQLVGNPVQYCLNQGQWTQPLPHCERIRCGVPPPLENGFH       SADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYI       CSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNH       LIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKC       SSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAV       ITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGD       IAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVS       FKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFY       IKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVC       QANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKK       SNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLC       TPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNG       IIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYG       QTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPG       FQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYH       LGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPT       APENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGS       NYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEY       TCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHG       APKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNG       SWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEH       TSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVA       NAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDF       SVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIY       QCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEG       PSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPD       ETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICR       AVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQ       SPCLNGGKCVRPNRCHCLSSWTGHNCSRKRRTGF                                             NOV8b, 237582568   SEQ ID NO: 179   2127 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             CGGCCGTGGGCGACCTTTCAGCAGATGTCCCCGTCGCGCAATTTCAGCTTCCGCCTCTTCCCCGAGAC           CGCGCCCGGGGCCCCCGGGAGTATCCCCGCGCCGCCCGCTCCTGGCGACGAAGCGGCGGGGAGCAGAG       TGGAGCGGCTGGGCCAGGCGTTCCGGCGACGCGTGCGGCTGCTGCGGGAGCTCAGCGAGCGCCTGGAG       CTTGTCTTCCTGGTGGATGATTCGTCCAGCGTGGGCGAAGTCAACTTCCGCAGCGAGCTCATGTTCGT       CCGCAAGCTGCTGTCCGACTTCCCCGTGGTGCCCACGGCCACGCGCGTGGCCATCGTGACCTTCTCGT       CCAAGAACTACGTGGTGCCGCGCGTCGATTACATCTCCACCCGCCGCGCGCGCCAGCACAAGTGCGCG       CTGCTCCTCCAAGAGATCCCTGCCATCTCCTACCGAGGTGGCGGCACCTACACCAAGGGCGCCTTCCA       GCAAGCCGCGCAAATTCTTCTTCATGCTAGAGAAAACTCAACAAAAGTTGTATTTCTCATCACTGATG       GATATTCCAATGGGGGAGACCCTAGACCAATTGCAGCGTCACTGCGAGATTCAGGAGTGGAGATCTTC       ACTTTTGGCATATGGCAAGGGAACATTCGAGAGCTGAATGACATGGCTTCCACCCCAAAGGAGGAGCA       CTGTTACCTGCTACACAGTTTTGAAGAATTTGAGGCTTTAGCTCGCCGGGCATTGCATGAAGATCTAC       CTTCTGGGAGTTTTATTCAAGATGATATGGTCCACTGCTCATATCTTTGTGATGAAGGCAAGGACTGC       TGTGACCGAATGGGAAGCTGCAAATGTGGGACACACACAGGCCATTTTGAGTGCATCTGTGAAAAGGG       GTATTACGGGAAAGGTCTGCAGTATGAATGdACAGCTTGCCCATCGGGGACATACAAACCTGAAGCCT       CACCAGGAGGAATCAGCAGTTGCATTCCATGTCCTGATGAAAATCACACCTCTCCACCTGGAAGCACA       TCCCCTGAAGACTGTGTCTGCAGAGAGGGATACAGGGCATCTGGCCAGACCTGTGAACTTGTCCACTG       CCCTGCCCTGAAGCCTCCCGAAAATGGTTACTTTATCCAAAACACTTGCAACAACCACTTCAATGCAG       CCTGTGGGGTCCGATGTCACCCTGGATTTGATCTTGTGGGAAGCAGCATCATCTTATGTCTACCCAAT       GGTTTGTGGTCCGGTTCAGAGAGCTACTGCAGAGTAAGAACATGTCCTCATCTCCGCCAGCCGAAACA       GGTACAGACTAGAAGGCAGTGATAAGCTTACTTGTCAAGGAAACAGCCAGTGGGATGGGCCAGAACCC       CGGTGTGTGGAGCGCCACTGTTCCACCTTTCAGATGCCCAAAGATGTCATCATATCCCCCCACAACTG       TGGCAAGCAGCCAGCCAAATTTGGGACGATCTGCTATGTAAGTTGCCGCCAAGGGTTCATTTTATCTG       GAGTCAAAGAAATGCTGAGATGTACCACTTCTGGAAAATGGAATGTCGGAGTTCAGGCAGCTGTGTGT       AAAGACGTGGAGGCTCCTCAAATCAACTGTCCTAAGGACATAGAGGCTAAGACTCTGGAACAGCAAGA       TTCTGCCAATGTTACCTGGCAGATTCCAACAGCTAAAGACAACTCTGGTGAAAAGGTGTCAGTCCACG       TTCATCCAGCTTTCACCCCACCTTACCTTTTCCCAATTGGAGATGTTGCTATCGTATACACGGCAACT       GACCTATCCGGCAACCAGGCCAGCTGCATTTTCCATATCAAGGTTATTGATGCAGAACCACCTGTCAT       AGACTGGTGCAGATCTCCACCTCCCGTCCAGGTCTCGGAGAAGGTACATGCCGCAAGCTGGGATGAGC       CTCAGTTCTCAGACAACTCAGGGGCTGAATTGGTCATTACCAGAAGTCATACACAAGGAGACCTTTTC       CCTCAAGGGGAGACTATAGTACAGTATACAGCCACTGACCCCTCAGGCAATAATAGGACATGTGATAT       CCATATTGTCATACTCGAG                                         NOV8b, 237582568                                     Protein Sequence   SEQ ID NO: 180   709 aa   MW at 78072.4kD                             RPWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRVERLGQAFRRRVRLLRELSERLE           LVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRVDYISTRPARQHKCA       LLLQEIPAlSYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPIAASLRDSGVEIF       TFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMVHCSYLCDEGKDC       CDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEASPGGISSCIPCPDENHTSPPGST       SPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPN       GLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEP       RCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVC       KDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEKVSVHVHPAFTPPYLFPIGDVAIVYTAT       DLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWDEPQFSDNSGAELVITRSHTQGDLF       PQGETIVQYTATDPSGNNRTCDIHIVILE                                             NOV8c, 236589434   SEQ ID NO: 181   2127 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             CGGCCGTGGGCGACCTTTCAGCAGATGTCCCCGTCGCGCAATTTCAGCTTCCGCCTCTTCCCCGAGAC           CGCGCCCGGGGCCCCCGGGAGTATCCCCGCGCCGCCCGCTCCTGGCGACGAAGCGGCGGGGAGCAGAG       TGGAGCGGCTGGGCCAGGCGTTCCGGCGACGCGTGCGGCTGCTGCGGGAGCTCAGCGAGCGCCTGGAG       CTTGTCTTCCTGGTGGATGATTCGTCCAGCGTGGGCGAAGTCAACTTCCGCAGCGAGCTCATGTTCGT       CCGCAAGCTGCTGTCCGACTTCCCCGTGGTGCCCACGGCCACGCGCGTGGCCATCGTGACCTTCTCGT       CCAAGAACTACGTGGTGCCGCGCGTCGATTACATCTCCACCCGCCGCGCGCGCCAGCACAAGTGCGCG       CTGCTCCTCCAAGAGATCCCTGCCATCTCCTACCGAGGTGGCGGCACCTACACCAAGGGCGCCTTCCA       GCAAGCCGCGCAAATTCTTCTTCATGCTAGAGAAAACTCAACAAAAGTTGTATCTCTCATCACTGATG       GATATTCCAATGGQGGAGACCCTAGACCAATTGCAGCGTCACTGCGAGATTCAGGAGTGGAGATCTTC       ACTTTTGGCATATGGCAAGGGAACATTCGAGAGCTGAATGACATGGCTTCCACCCCAAAGGAGGAGCA       CTGTTACCTGCTACACAGTTTTGAAGAATTTGAGGCTTTAGCTCGCCGGGCATTGCATGAAGATCTAC       CTTCTGGGAGTTTTATTCAAGATGATATGGTCCACTGCTCATATCTTTGTGATGAAGGCAAGGACTGC       TGTGACCGAATGGGAAGCTGCAAATGTGGGACACACACAGACCGTTTTGAGTGCATCTGTGAAAAGGG       GTATTACGGGAAAGGTCTGCAGTATGAATGCACAGCTTGCCCATCGGGGACATACAAACCTGAAGGCT       CACCAGGAGGAATCAGCAGTTGCATTCCATGTCCTGATGAAAATCACACCTCTCCACCTGGAAGCACA       TCCCCTGAAGACTGTGTCTGCAGAGAGGGATACAGGGCATCTGGCCAGACCTGTGAACTTGTCCACTG       CCCTGCCCTGAAGCCTCCCGAAAATGGTTACTTTATCCAAAACACTTGCAACAACCACTTCAATGCAG       CCTGTGGGGTCCGATGTCACCCTGGATTTGATCTTGTGGGAAGCAGCATCATCTTATGTCTACCCAAT       GGTTTGTGGTCCGGTTCAGAGAGCTACTGCAGAGTAAGAACATGTCCTCATCTCCGCCAGCCGAAACA       TGGCCACATCAGCTGTTCTACAAGGGAAATGTTATATAAGACAACATGTTTGGTTGCCTGTGATGAAG       GGTACAGACTAGAAGGCAGTGATAAGCTTACTTGTCAAGGAAACAGCCAGTGGGATGGGCCAGAACCC       CGGTGTGTGGAGCGCCACTGTTCCACCTTTCAGATGCCCAAAGATATCATCATATCCCCCCACAACTG       TGGCAAGCAGCCAGCCAAATTTGGGACGATCTGCTATGTAAGTTGCCGCCAAGGGTTCATTTTATCTG       GAGTCAAAGAAATGCTGAGATGTACCACTTCTGGAAAATGGAATGTAGGAGTTCAGGCAGCTGTGCGT       AAAGACGTGGAGGCTCCTCAAATCAACTGTCCTAAGGACATAGAGGCTAAGACTCTGGAACAGCAAGA       TTCCGCCAATGTTACCTGGCAGATTCCAACAGCTAAAGACAACTCTGGTGAAAAGGTGTCAGTCCACG       TTCATCCAGCTTTCACCCCACCTTACCTTTTCCCAATTGGAGATGTTGCTATCGTATACACGGCAACT       GACCTATCCGGCAACCAGGCCAGCTGCATTTTCCATATCAAGGTTATTGATGCAGAACCACCTGTCAT       AGACTGGTGCAGATCTCCACCTCCCGTCCAGGTCTCGGAGAAGGTACATGCCGCAAGCTGGGATGAGC       CTCAGTTCTCAGACAACTCAGGGGCTGAATTGGTCATTACCAGAAGTCATACACAAGGAGACCTTTTC       CCTCAAGGGGAGACTATAGTACAGTATACAGCCACTGACCCCTCAGGCAATAACAGGACATGTGATAT       CCATATTGTCATACTCGAG                                         NOV8c, 236589434                                     Protein Sequence   SEQ ID NO: 182   709 aa   MW at 78142.4kD                             RPWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRVERLGQAFRRRVRLLRELSERLE           LVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRVDYISTRRARQHKCA       LLLQEIPATSYRGGGTYTKGAFQQAAQILLHARENSTKVVSLITDGYSNGGDPRPIAASLRDSGVEIF       TFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALARPALHEDLPSGSFIQDDMVHCSYLCDEGKDC       CDRMGSCKCGTHTDRFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGST       SPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPN       GLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEP       RCVERHCSTFQMPKDIIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVR       KDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEKVSVHVHPAFTPPYLFPIGDVAIVYTAT       DLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWDEPQFSDNSGAELVITRSHTQGDLF       PQGETIVQYTATDPSGNNRTCDIHIVILE                                             NOV8d, 236495259   SEQ ID NO: 183   2127 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             CGGCCGTGGGCGACCTTTCAGCAGATGTCCCCGTCGCGCAATTTCAGCTTCCGCCTCTTCCCCGAGAC           CGCGCCCGGGGCCCCCGGGAGTATCCCCGCGCCGCCCGCTCCTGGCGACGAAGCGGCGGGGAGCAGAG       TGGAGCGGCTGGGCCAGGCGTTCCGGCGACGCGTGCGGCTGCTGCGGGAGCTCAGCGAGCGCCTGGAG       CTTGTCTTCCTGGTGGATGATTCGTCCAGCGTGGGCGAAGTCAACTTCCGCAGCGAGCTCATGTTCGT       CCGCAAGCTGCTGTCCGACTTCCCCGTGGTGCCCACGGCCACGCGCGTGGCCATCGTGACCTTCTCGT       CCAAGAACTACGTGGTGCCGCGCGTCGATTACATCTCCACCCGCCGCGCGCGCCAGCACAAGTGCGCG       CTGCTCCTCCAAGAGATCCCTGCCATCTCCTACCGAGGTGGCGGCACCTACATCAAGGGCGCCTTCCA       GCAAGCCGCGCAAATTCTTCTTCATGCTAGAGAAAACTCAACAAAAGTTGTATTTCTCATCACTGATG       GATATTCCAATGGGGGAGACCCTAGACCAATTGCAGCGTCACTGCGAGATTCAGGAGTGGAGATCTTC       ACTTTTGGCATATGGCAAGGGAACATTCGAGAGCTGAATGACATGGCTTCCACCCCAAAGGAGGAGCA       CTGTTACCTGCTACACAGTTTTGAAGAATTTGAGGCTTTAGCTCGCCGGGCATTGCATGAAGATCTAC       CTTCTGGGAGTTTTATTCAAGATGATATGGTCCACTGCTCATATCTTTGTGATGAAGGCAAGGACTGC       TGTGACCGAATGGGAAGCTGCAAATGTGGGACACACACAGGCCATTTTGAGTGCATCTGTGAAAAGGG       GTATTACGGGAAAGGTCTGCAGTATGAATGCACAGCTTGCCCATCGGGGACATACAAACCTGAAGGCT       CACCAGGAGGAATCAGCAGTTGCATTCCATGTCCTGATGAAAATCACACCTCTCCACCTGGAAGCACA       TCCCCTGAAGACTGTGTCTGCAGAGAGGOATACAGGGCATCTGGCCAGACCTGTGAACTTGTCCACTG       CCCTGCCCTGAAGCCTCCCGAAAATGGTTACTTTATCCAAAACACTTGCAACAACCACTTCAATGCAG       CCTGTGGGGTCCGATGTCACCCTGGATTTGATCTTGTGGGAAGCAGCATCATCTTATGTCTACCCAAT       GGTTTGTGGTCCGGTTCAGAGAGCTACTGCAGAGTAAGAACATGTCCTCATCTCCGCCAGCCGAAACA       TGGCCACATCAGCTGTTCTACAAGGGAAATGTTATATAAGACAACATGTTTGGTTGCCTGTGATGAAG       GGTACAGACTAGAAGGCAGTGATAAGCTTACTTGTCAAGGAAACAGCCAGTGGGATGGGCCAGAACCC       CGGTGTGTGGAGCGCCACTGTTCCACCTTTCAGATGCCCAAAGATGTCATCATATCCCCCCACAACTG       TGGCAAGCAGCCAGCCAAATTTGGGACGATCTGCTATGTAAGTTGCCGCCAAGGGTTCATTTTATCTG       GAGTCAAAGAAATGCTGAGATGCACCACTTCTGGAAAATGGAATGTCGGAGTTCAGGCAGCTGTGTGT       AAAGACGTGGAGGCTCCTCAAATCAACTGTCCTAAGGACATAGAGGCTAAGACTCTGGAACAGCAAGA       TTCTGCCAATGTTACCTGGCAGATTCCAACAGCTAAAGACAACTCTGGTGAAAAGGTGTCAGTCCACG       TTCATCCAGCTTTCACCCCACCTTACCTTTTCCCAATTGGAGATGTTGCTATCGTATACACGGCAACT       GACCTATCCGGCAACCAGGCCAGCTGCATTTTCCATATCAAGGTTATTGATGCAGAACCACCTGTCAT       AGACTGGTGCAGATCTCCACCTCCCGTCCAGGTCTCGGAGAAGGTACATGCCGCAAGCTGGGATGAGC       CTCAGTTCTCAGACAACTCAGGGGCCGAATTGGTCATTACCAGAAGTCATACACAAGGAGACCTTTTC       CCTCAAGGGGAGACTATAGTACAGTATACAGCCACTGACCCCTCAGGCAATAACAGGACATGTGATAT       CCATATTGTCATACTCGAG                                         NOV8d, 236495259                                     Protein sequence   SEQ ID NO: 184   709 aa   MW at 78070.4kD                             RPWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRVERLGQAFRRRVRLLRELSERLE           LVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRVDYISTRRARQHKCA       LLLQEIPAlSYRGGGTYIKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPIAASLRDSGVEIF       TFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMVHCSYLCDEGKDC       CDPMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGST       SPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPN       GLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEP       RCVERNCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVC       KDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEKVSVHVHPAFTPPYLFPIGDVAIVYTAT       DLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWDEPQFSDNSGAELVITRSHTQGDLF       PQGETIVQYTATDPSGNNRTCDIHIVILE                                             NOV8e, 236495256   SEQ ID NO: 185   2127 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             CGGCCGTGGGCGACCTTTCAGCAGATGTCCCCGTCGCGCAATTTCAGCTTCCGCCTCTTCCCCGAGAC           CGCGCCCGGGGCCCCCGGGAGTATCCCCGCGCCGCCCGCTCCTGGCGACGAAACGGCGGGGAGCAGAG       TGGAGCGGCTGGGCCAGGCGTTCCGGCGACGCGTGCGGCTGCTGCGGGAGCTCAGCGAGCGCCTGGAG       CTTGTCTTCCTGGTGGATGATTCGTCCAGCGTGGGCGAAGTCAACTTCCGCAGCGAGCTCATGTTCGT       CCGCAAGCTGCTGTCCGACTTCCCCGTGGTGCCCACGGCCACGCGCGTGGCCATCGTGACCTTCTCGT       CCAAGAACTACGTGGTGCCGCGCGCCGATTACATCTCCACCCGCCGCGCGCGCCAGCACAAGTGCGCG       CTGCTCCTCCAAGAGATCCCTGCCATCTCCTACCGGGGTGGCGGCACCTACACCAAGGGCGCCTTCCA       GCAAGCCGCGCAAATTCTTCTTCATGCTAGAGAAAACTCAGCAAAAGTTGTATTTCTCATCACTGATG       GATATTCCAATGGGGGAGACCCTAGACCAATTGCAGCGTCACTGCGAGATTCAGGAGTGGAGATCTTC       ACTTTTGGCATATGGCAAGGGAACATTCGAGAGCTGAATGACATGGCTTCCACCCCAAAGGAGGAGCA       CTGTTACCTGCTACACAGTTTTGAAGAATTTGAGGCTTTAGCTCGCCGGGCATTGCATGAAGATCTAC       CTTCTGGGAGTTTTATTCAAGATGATATGGTCCACTGCTCATATCTTTGTGATGAAGGCAAGGACTGC       TGTGACCGAATGGGAAGCTGCAAATGTGGGACACACACAGGCCATTTTGAGTGCATCTGTGAAAAGGG       GTATTACGGGAAGGGTCTGCAGTATGAATGCACAGCTTGCCCATCGGGGACATACAAACCTGAAGGCT       CACCAGGAGGAATCAGCAGTTGCATTCCATGTCCTGATGAAAATCACACCTCTCCACCTGGAAGCACA       TCCCCTGAAGACTGTGTCTGCAGAGAGGGATACAGGGCATCTGGCCAGACCTGTGAACTTGTCCACTG       CCCTGCCCTGAAGCCTCCCGAAAATGGTTACTTTATCCAAAACACTTGCAACAACCACTTCAATGCAG       CCTGTGGGGTCCGATGTCACCCTGGATTTGATCTTGTGGGAAGCAGCATCATCTTATGTCTACCCAAT       GGTTTGTGGTCCGGTTCAGAGAGCTACTGCAGAGTAAGAACATGTCCTCATCTCCGCCAGCCGAAACA       TGGCCACATCAGCTGTTCTACAAGGGAAATGTTATATAAGACAACATGTTTGGTTGCCTGTGATGAAG       GGTACAGACTAGAAGGCAGTGATAAGCTTACTTGTCAAGGAAACAGCCAGTGGGATGGGCCAGAACCC       CGGTGTGTGGAGCGCCACTGTTCCACCTTTCAGATGCCCAAAGATATCATCATATCCCCCCACAACTG       TGGCAAGCAGCCAGCCAAATTTGGGACGATCTGCTATGTAAGTCGCCGCCAAGGGTTCATTTTATCTG       GAGTCAAAGAAATGCTGAGATGTACCACTTCTGGAAAATGGAATGTCGGAGTTCAGGCAGCTGTGTGT       AAAGACGTGGAGGCTCCTCAAATCAACTGTCCTAAGGACATAGAGGCTAAGACTCTGGAACAGCAAGA       TTCTGCCAATGTTACCTGGCAGATTCCAACAGCTAAAGACAACTCTGGTGAAAAGGTGTCAGTCCACG       TTCATCCAGCTTTCACCCCACCTTACCTTTTCCCAATTGGAGATGTTGCTATCGTATACACGGCAACT       GACCTATCCGGCAACCAGGCCAGCTGCATTTTCCATATCAAGGTTATTGATGCAGAACCACCTGTCAT       AGACTGGTGCAGATCTCCACCTCCCGTCCAGGTCTCGGAGAAGGTACATGCCGCAAGCTGGGATGAGC       CTCAGTTCTCAGACAACTCAGGGGCTGAATTGGTCATTACCAGAAGTCATACACAAGGAGAACTTTTC       CCTCAAGGGGAGACTATAGTACAGTATACAGCCACTGACCCCTCAGGCAATAACAGGACATGTGATAT       CCATATTGTCATACTCGAG                                         NOV8e, 236495256                                     Protein Sequence   SEQ ID NO: 186   709 aa   MW at 78081.3kD                             RPWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRVERLGQAFRRRVRLLRELSERLE           LVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRADYISTRRARQHKCA       LLLQEIPAISYRGGGTYTKGAFQQAAQILLHARENSAKVVFLITDGYSNGGDPRPIAASLRDSGVEIF       TFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMVHCSYLCDEGKDC       CDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGST       SPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPN       GLWSGSESYCRVRTCPHLRQPKHGHISCSTREMWYKTTCLVACDEGYPLEGSDKLTCQGNSQWDGPEP       RCVERHCSTFQMPKDIIISPHNCGKQPAKFGTICYVSRRQGFILSGVKEMLRCTTSGKWNVGVQAAVC       KDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEKVSVHVHPAFTPPYLFPIGDVAIVYTAT       DLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWDEPQFSDNSGAELVITRSHTQGELF       PQGETIVQYTATDPSGNNRTCDIHIVILE                                             NOV8f, CG50646-01   SEQ ID NO: 187   1952 bp                             DNA Sequence   ORF Start: ATG at 470   ORF Stop: TGA at 1688                             TTCAGGAACACCGTCACTTACACTTGCAAAGAAGGCTATACTCTTGCTGGTCTTGACACCATTGAATG           CCTGGCCGACGGCAAGTGGAGTAGAAGTGACCAGCAGTGCCTGGCTGTCTCCTGTGATGAGCCACCCA       TTGTGGACCACGCCTCTCCAGAGACTGCCCATCGGCTCTTTGGAGACATTGCATTCTACTACTGCTCT       GATGGTTACAGCCTAGCAGACAATTCCCAGCTTCTCTGCAATGCCCAGGGCAAGTGGGTACCCCCAGA       AGGTCAAGACATGCCCCGTTGTATAGCTCATTTCTGTGAAAAACCTCCATCGGTTTCCTATAGCATCT       TGGAATCTGTGAGCAAAGCAAAATTTGCAGCTGGCTCAGTTGTGAGCTTTAAATGCATGGAAGGCTTT       GTACTGAACACCTCAGCAAAGATTGAATGTATGAGAGGTGGGCAGTGGAACCCTTCCCCCCATGTCCA       TCCAGTGCATCCCTGTGCGGTGTGGAGAGCCACCAAGCATCATGAATGGCTATGCAAGTGGATCAAAC       TACAGTTTTGGAGCCATGGTGGCTTACAGCTGCAACAAGGGGTTCTACATCAAAGGGGAAAAGAAGAG       CACCTGCGAAGCCACAGGGCAGTGGAGTAGTCCTATACCGACGTGCCACCCGGTATCTTGTGGTGAAC       CACCTAAGGTTGAGAATGGCTTTCTGGAGCATACACCTGGCAGGATCTTTGAGAGTGAAGTGAGGTAT       CAGTGTAACCCGGGCTATAAGTCAGTCGGAAGTCCTGTATTTGTCTGCCAAGCCAATCGCCACTGGCA       CAGTGAATCCCCTCTGATGTGTGTTCCTCTCGACTGTGGAAAACCTCCCCCGATCCAGAATGGCTTCA       TGAAAGGAGAAAACTTTGAAGTAGGGTCCAAGGTTCAGTTTTTCTGTAATGAGGGTTATGAGCTTGTT       GGGGACAGTTCTTGGACATGTCAGAAATCTGGCAAATGGAATAAGAAGTCAAATCCAAAGTGCATGCC       TGCCAAGTGCCCAGAGCCGCCCCTCTTGGAAAACCAGCTAGTATTAAAGGAGTTGACCACCGAGGTAG       GAGTTGTGACATTTTCCTGTAAAGAAGGGCATGTCCTGCAAGGCCCCTCTGTCCTGAAATGCTTGCCA       TCCCAGCAATGGAATGACTCTTTCCCTGTTTGTAAGATTGTTCTTTGTACCCCACCTCCCCTAATTTC       CTTTGGTGTCCCCATTCCTTCTTCTGCTCTTCATTTTGGAAGTACTGTCAAGTATTCTTGTGTAGGTG       GGTTTTTCCTAAGAGGAAATTCTACCACCCTCTGCCAACCTGATGGCACCTGGAGCTCTCCACTGCCA       GAATGTGTTCCAGTAGAATGTCCCCAACCTGAGGAAATCCCCAATGGAATCATTGATGTGCAAGGCCT       TGCCTATCTCAGCACAGCTCTCTATACCTGCAAGCCAGGCTTTGAATTGGTGGGAAATACTACCACCC       TTTGTGGAGAAAATGGTCACTGGCTTGGAGGAAAACCAACATGTAAAGCCATTGAGTGCCTGAAACCC       AAGGAGATTTTGAATGGCAAATTCTCTTACACGGACCTACACTATGGACAGACCGTTACCTACTCTTG       CAACCGAGGCTTTCGGCTCGAAGGGTCCCAGTGCCTTGACCTGTTTAGAGACAGGTGATTGGGATGTA       GATGCCCCATCTTGCAATGCCATCCACTGTGATTCCCCACAACCCATTGAAAATGGTTTTGTAGAAGC       TGCAGATTACAGCTATGGTGCCATAATCATCTACAGTTGCTTCCCTGGGTTTCAGGTGGCTGGTCATC       CTCCCTCCTCATATAGATTTTGGAGACTGTACTAAACTCAAAGATGAC                                         NOV8f, CG50646-01                                     Protein Sequence   SEQ ID NO: 188   406 aa   MW at 44385.5kD                             MSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSC           GEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQN       GFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTT       EVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSC       VGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQLAYLSTALYTCKPGFELVGNT       TTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGSQCLDLFRDR                                             NOV8g, CG50646-02   SEQ ID NO: 189   1709 bp                             DNA Sequence   ORF Start: ATG at 413   ORF Stop: TGA at 1445                             CAGAGTCTTGCTCTGTCTCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAACCTCTGCCT           CCTGGGTTCAAGTGATTCTCCTGCCTCAGCTTCCCAAATGGCTGAGATTACAGGCACATACCACCATG       CCTAGCTAATTTTTGTACAGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTAACCTCAAGTGT       TCCTCCTGCCTCCGCCTCCCAAAGTGCTGGGATTGTAGGCATGAATCGTCATGCCGAGCCTAAGTTGA       CTTTCTACTATCATTTTCACTTATTTAAAAAAATAGAATGGATCTATTGGAAAAACCATAAATCATTA       TTTGCTTACTTCCTAATTGATTCATTTTAACATAGACCTTTTAGTTTTTTTCACTATCCAAGGATTTA       GTTAATGCTATCATCTGTTATACAAATCGCACTCACTTGCTTTCTTCCTGTTGCACAGCATACAACTG       GCAGGATCTTTGAGAGTGAAGTGAGGTATCAGTGTAACCCGGGCTATAAGTCAGTCGGAAGTCCTGTA       TTTGTCTGCCAAGCCAATCGCCACTGGCACAGTGAATCCCCTCTGATGTGTGTTCCTCTCGACTGTGG       AAAACCTCCCCCGATCCAGAATGGCTTCATGAAAGGAGAAAACTTTGAAGTAGGGTCCAAGGTTCAGT       TTTTCTGTAATGAGGGTTATGAGCTTGTTGGGGACAGTTCTTGGACATGTCAGAAATCTGGCAAATGG       AATAAGAAGTCAAATCCAAAGTGCATGCCTGCCAAGTGCCCAGAGCCGCCCCTCTTGGAAAACCAGCT       AGTATTAAAGGAGTTGACCACCGAGGTAGGAGTTGTGACATTTTCCTGTAAAGAAGGGCATGTCCTGC       AAGGCCCCTCTGTCCTGAAATGCTTGCCATCCCAGCAATGGAATGACTCTTTCCCTGTTTGTAAGATT       GTTCTTTGTACCCCACCTCCCCTAATTTCCTTTGGTGTCCCCATTCCTTCTTCTGCTCTTCATTTTGG       AAGTACTGTCAAGTATTCTTGTGTAGGTGGGTTTTTCCTAAGAGGAAATTCTACCACCCTCTGCCAAC       CTGATGGCACCTGGAGCTCTCCACTGCCAGAATGTGTTCCAGTAGAATGTCCCCAACCTGAGGAAATC       CCCAATGGAATCATTGATGTGCAAGGCCTTGCCTATCTCAGCACAGCTCTCTATACCTGCAAGCCAGG       CTTTGAATTGGTGGGAAATACTACCACCCTTTGTGGAGAAAATGGTCACTGGCTTGGAGGAAAACCAA       CATGTAAAGCCATTGAGTGCCTGAAACCCAAGGAGATTTTGAATGGCAAATTCTCTTACACGGACCTA       CACTATGGACAGACCGTTACCTACTCTTGCAACCGAGGCTTTCGGCTCGAAGGGTCCCAGTGCCTTGA       CCTGTTTAGAGACAGGTGATTGGGATGTAGATGCCCCATCTTGCAATGCCATCCACTGTGATTCCCCA       CAACCCATTGAAAATGGTTTTGTAGAAGGTGCAGATTACAGCTATGGTGCCATAATCATCTACAGTTG       CTTCCCTGGGTTTCAGGTGGCTGGTCATGCCATGCAGACCTGTGAAGAGTCAGGATGGTCACTCGTGC       CCCCAACATGTATGCCAATAGACTGTGGCCTCCCTCCTCATATAGATTTTGGAGACTGTACTAAACTC       AAAGATGAC                                         NOV8g, CG50646-02                                     Protein Sequence   SEQ ID NO: 190   344 aa   MW at 37763.2kD                             MLSSVIQIALTCFLPVAQHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGK           PPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLV       LKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGS       TVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGF       ELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGSQCLDL       FRDR                                             NOV8h, CG50646-03   SEQ ID NO: 191   6153 bp                             DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 6151                             ATGGCGGGCGCCCCTCCCCCAGCCTCGTTGCCGCCTTGCAGTTTGATCTCAGACTGCTGTGCTAGCAA           TCAGCGAGATTCCGTGGGCGTAGGACCCTCTGAGCCAGGTGTGGGATATAGTCTCGTGGTGCGCCGTT       TCTTAAGCCGGTCTGAAAAGCGCAATATTCGGGTGGGAGTGACCCGATTTTCCAGCTATACTCTTGCT       CTCCTGTGATGAGCCACCCATTGTGGACCACGCCTCTCCAGAGACTGCCCATCGGCTCTTTGGAGACA       TTGCATTCTACTACTGCTCTGATGGTTACAGCCTAGCAGACAATTCCCAGCTTCTCTGCAATGCCCAG       GGCAAGTGGGTACCCCCAGAAGGTCAAGACATGCCCCGTTGTATAGCTCATTTCTGTGAAAAACCTCC       ATCGGTTTCCTATAGCATCTTGGAATCTGTGAGCAAAGCAAAATTTGCAGCTGGCTCAGTTGTGAGCT       AACCCTTCCCCCATGTCCATCCAGTGCATCCCTGTGCGGTGTGGAGAGCCACCAAGCATCATGAATGG       TCAAAGGGGAAAAGAAGAGCACCTGCGAAGCCACAGGGCAGTGGAGTAGTCCTATACCGACGTGCCAC       CCGGTATCTTGTGGTGAACCACCTAAGGTTGAGAATGGCTTTCTGGAGCATACAACTGGCAGGATCTT       TGAGAGTGAAGTGAGGTATCAGTGTAACCCGGGCTATAAGTCAGTCGGAAGTCCTGTATTTGTCTGCC       AAGCCAATCGCCACTGGCACAGTGAATCCCCTCTGATGTGTGTTCCTCTCGACTGTGGAAAACCTCCC       CCGATCCAGAATGGCTTCATGAAAGGAGAAAACTTTGAAGTAGGGTCCAAGGGTCAGTTTTTCTGTAA       TGAAGGGTTATNGAGCTTTGTTGGGGACAGTTCTTGGACATGTCAGAAATCTGGCAAATGGAATAAGA       AGTCAAATCCAAAGTGCATGCCTGCCAAGTGCCCAGAGCCGCCCCTCTTGGAAAACCAGCTAGTATTA       AAGGAGTTGACCACCGAGGTAGGAGTTGTGACATTTTCCTGTAAAGAAAGGCATGTCCTGCAAGGCCC       CTCTGTCCTGAAATGCTTGCCATCCCAGCAATGGAATGACTCTTTCCCTGTTTGTAAGATTGTTCTTT       GTACCCCACCTCCCCTAATTTCCTTTGGTGTCCCCATTCCTTCTTCTGCTCTTCATTTTGGAAGTACT       GTCAAGTATTCTTGTGTAGGTGGGTTTTTCCTAAGAGGAAATTCTACCACCCTCTGCCAACCTGATGG       CACCTGGAGCTCTCCACTGCCAGAATGTGTTCCAGTAGAATGTCCCCAACCTGAGGAAATCCCCAATG       GAATCATTGATGTGCAAGGCCTTGCCTATCTCAGCACAGCTCTCTATACCTGCAAGCCAGGCTTTGAA       TTGGTGGGAAATACTACCACCCTTTGTGGAGAAAATGGTCACTGGCTTGGAGGAAAACCAACATGTAA       AGCCATTGAGTGCCTGAAACCCAAGGAGATTTTGAATGGCAAATTCTCTTACACGGACCTACACTATG       GACAGACCGTTACCTACTCTTGCAACCGAGGCTTTCGGCTCGAAGGTCCCAGTGCCTTGACCTGTTTA       GAGACAGGTGATTGGGATGTAGATGCCCCATCTTGCAATGCCATCCACTGTGATTCCCCACAACCCAT       TGAAAATGGTTTTGTAGAAGGTGCAGATTACAGCTATGGTGCCATAATCATCTACAGTTGCTTCCCTG       GGTTTCAGGTGGCTGGTCATGCCATGCAGACCTGTGAAGAGTCAGGATGGTCAAGTTCCATCCCAACA       TGTATGCCAATAGACTGTGGCCTCCCTCCTCATATAGATTTTGGAGACTGTACTAAACTCAAAGATGA       CCAGGGATATTTTGAGCAAGAAGACGACATGATGGAAGTTCCATATGTGACTCCTCACCCTCCTTATC       ATTTGGGAGCAGTGGCTAAAACCTGGGAAAATACAAAGGAGTCTCCTGCTACACATTCATCAAACTTT       CTGTATGGTACCATGGTTTCATACACCTGTAATCCAGGATATGAACTTCTGGGGAACCCTGTGCTGAT       CTGCCAGGAAGATGGAACTTGGAATGGCAGTGCACCATCCTGCATTTCAATTGAATGTGACTTGCCTA       CTGCTCCTGAAAATGGCTTTTTGCGTTTTACAGAGACTAGCATGGGAAGTGCTGTGCAGTATAGCTGT       AAACCTGGACACATTCTAGCAGGCTCTGACTTAAGGCTTTGTCTAGAGAATAGAAAGTGGAGTGGTGC       CTCCCCACGCTGTGAAGCCATTTCATGCAAAAAGCCAAATCCAGTCATGAATGGATCCATCAAAGGAA       GCAACTACACATACCTGAGCACGTTGTACTATGAGTGTGACCCCGGATATGTGCTGAATGGCACTGAG       AGGAGAACATGCCAGGATGACAAAAACTGGGATGAGGATGAGCCCATTTGCATTCCTGTGGACTGCAG       TTCACCCCCAGTCTCAGCCAATGGCCAGGTGAGAGGAGACGAGTACACATTCCAAAAAGAGATTGAAT       ACACTTGCAATGAAGGGTTCTTGCTTGAGGGAGCCAGGAGTCGGGTTTGTCTTGCCAATGGAAGTTGG       AGTGGAGCCACTCCCGACTGTGTGCCTGTCAGATGTGCCACCCCGCCACAACTGGCCAATGGGGTGAC       GGAAGGCCTGGACTATGGCTTCATGAAGGAAGTAACATTCCACTGTCACGAGGGCTACATCTTGCACG       GTGCTCCAAAACTCACCTGTCAGTCAGATGGCAACTGGGATGCAGAGATTCCTCTCTGTAAACCAGTC       AACTGTGGACCTCCTGAAGATCTTGCCCATGGTTTCCCTAATGGTTTTTCCTTTATTCATGGGGGCCA       TATACAGTATCAGTGCTTTCCTGGTTATAAGCTCCATGGAAATTCATCAAGAAGGTGCCTCTCCAATG       GCTCCTGGAGTGGCAGCTCACCTTCCTGCCTGCCTTGCAGATGTTCCACACCAGTAATTGAATATGGA       ACTGTCAATGGGACAGATTTTGACTGTGGAAAGGCAGCCCGGATTCAGTGCTTCAAAGGCTTCAAGCT       CCTAGGACTTTCTGAAATCACCTGTGAAGCCGATGGCCAGTGGAGCTCTGGGTTCCCCCACTGTGAAC       ACACTTCTTGTGGTTCTCTTCCAATGATACCAAATGCGTTCATCAGTGAGACCAGCTCTTGGAAGGAA       AATGTGATAACTTACAGCTGCAGGTCTGGATATGTCATACAAGGCAGTTCAGATCTGATTTGTACAGA       GAAAGGGGTATGGAGCCAGCCTTATCCAGTCTGTGAGCCCTTGTCCTGTGGGTCCCCACCGTCTGTCG       CCAATGCAGTGGCAACTGGAGAGGCACACACCTATGAAAGTGAAGTGAAACTCAGATGTCTGGAAGGT       TATACGATGGATACAGATACAGATACATTCACCTGTCAGAAAGATGGTCGCTGGTTCCCTGAGAGAAT       CTCCTGCAGTCCTAAAAAATGTCCTCTCCCGGAAAACATAACACATATACTTGTACATGGGGACGATT       TCAGTGTGAATAGGCAAGTTTCTGTGTCATGTGCAGAAGGGTATACCTTTGAGGGAGTTAACATATCA       GTATGTCAGCTTGATGGAACCTGGGAGCCACCATTCTCCGATGAATCTTGCAGTCCAGTTTCTTGTGG       GAAACCTGAAAGTCCAGAACATGGATTTGTGGTTGGCAGTAAATACACCTTTGAAAGCACAATTATTT       ATCAGTGTGAGCCTGGCTATGAACTAGAGAATTTGGCTGTGAATCCATCTGGTCCTGGACTTTTCTTG       ATCAGCAGCAGAGGGTGCAGAACAGCGGATATTGGTGAACCGCAAATGCTGCTGCCTGATCATTCCTC       TGGAAGTTTTGTCTCAGAGGAATACCCGGCCATGTGAGGTGTCAGTCCGCCCCTACTGGGGGGGGAAC       AGGGAACGTGTCTGCCAGGAGAACAGACAGTGGAGTGGAGGGGTGGCAATATGCAAAGAGACCAGGTG       TGAAACTCCACTTGAATTTCTCAATGGGAAAGCTGACATTGAAAACAGGACGACTGGACCCAACGTGG       TATATTCCTGCAACAGAGGCTACAGTCTTGAAGGGCCATCTGAGGCACACTGCACAGAAAATGGAACC       TGGAGCCACCCAGTCCCTCTCTGCAAACCAAATCCATGCCCTGTTCCTTTTGTGATTCCCGAGAATGC       TCTGCTGTCTGAAAAGGAGTTTTATGTTGATCAGAATGTGTCCATCAAATGTAGGGAAGGTTTTCTGC       TGCAGGGCCACGGCATCATTACCTGCAACCCCGACGAGACGTGGACACAGACAAGCGCCAAATGTGAA       AGAAGATATACACAACAGCCCAAGTCCCTGAATTTTCAGCTAGCAGCTTATTGCAGTATTAGAATGTT       TATTTTGCGGGGAGGGGTTCAAGATGGCCAACTAGAAACAGCTGTGGCCGGAGCCTCCCACCGAGAAG       AACAAAAACAAAAGCGAGAAAAAGCAAGGTGGTACAACGGCCCACCTGGGAGCCACATGGGGCAAGCA       GAGCTCCCACCCCCAGCCAAAGGAGGTGGACCTCCCTGCGGGAATTTCAGCAACTCCAGCCAGGGGTT       TATGAACAGACCTCTGATCTCCCTGAGATGGAGCCCCTGGGGCTCCATGTGGCCATGGTCTCCACAGA       AACAGCACAGTTTACCTGCTCTGCCAAGGGGCAGCTAGAGCGCTTTGTTAAGCGAGTCCCTGATCCCA       GAGCTCCCACCCCCAGCCAAAGGAGGTGGACCTCCCTGCGGGAATTTCAGCAACTCCAGCCAGGGGTT       TATGAACAGACCTCTGATCTCCCTGAGATGGAGCCCCTGGGGCTCCATGTGGCCATGGTCTCCACAGA       TCAGCAGGCTTAGTCCTTCCCCTGCTGGCTCTGAGGAATCCAGGCAGGCTGGACTAGTGGGATTCCCC       ACAGCACAGTTTACCTGCTCTGCCAAGGGGCAGCTAGAGCGCTTTGTTAAGCGAGTCCCTGATCCCAT       GCCTCCTGATTGGGATGAGACCCCCCCACAACAGGGGTCACGGATGAGACCCCCCCACAACAGGGGTC       ACCAGACACCTTATACAAGGGTGTTCCTGCTAGCATCAGGTCAGTGCCCCTCTGGGACAGAGCTCCCA       GAGGAAAGAGCAGGCAGCCATCTTTGCTGTTCTGCAGCGTCCGCTGGAAAAGCACAGAATTGGGCAGA       GGCTAGGATTGATGAATTGAAAGAAGTAGGCTTCAGAAAGTGGGTAATAATGAAGTTCGCTGAGCTAA       AGGAACATGTTCTAAACCAATGCAIAGACGCCAAGAACCAGGATAAAACATTACAGGATCCGTTAACC       AGAATAACCAGTTTAGAAAGGAATGTAAATGACCTGATGGAGCTGAAAAACACAACACGAGAACTTCA       CAATGCAACAACAAAACAAGGCCAACATTCFAGTTCAGGAAATCCAGAGAACCCCAGTAAGATACTCC       ATGAGAAGATCAACCCCAAGACACATAATCCTCAGGTTCTCCAAGAAATCTCATGTGGTCCACCAGCT       CACGTAGAAAATGCAATTGCTCGAGGCGTACATTATCAATATGGAGACATGATCACCTACTCATGTTA       CAGTGGATACATGTTGGAGGGTTTCCTGAGGAGTGTTTGTTTAGAAAATGGAACATGGACATCACCTC       CTATTTGCAGAGCTGTCTGTCGATTTCCATGTCAGAATGGGGGCATCTGCCAACGCCCAAATGCTTGT       TCCTGTCCAGAGGGCTGGATGGGGCGCCTCTGTGAAGAACCAATCTGCATTCTTCCCTGTCTGAACGG       AGGTCGCTGTGTGGCCCCTTACCAGTGTGACTGCCCGCCTGGCTGGACGGGGTCTCGCTGTCATACAG       GTAGGCCTCTTTCATGGTTTGTTTTCTTGGTGGCTCAGGCCCATGAAACTCCAGAGGACATTGAAGAG       TGTGACTTAGACTCAGAAGTGGTGGCAAAATGA                                         NOV8h, CG50646-03                                     Protein Sequence   SEQ ID NO: 192   2050 aa   MW at 224498.2kD                             MAGAPPPASLPPCSLISDCCASNQRDSVGVGPSEPGVGYSLVVRRFLSRSEKRNIRVGVTRFSSYTLA           GLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQ       GKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQW       NPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCH       PVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPP       PIQNGFMKGENFEVGSKGQFFCNEGLXSFVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVL       KELTTEVGVVTFSCKERHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGST       VKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFE       LVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCL       ETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSIPT       CMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNF       LYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSC       KPGHILAGSDLRICLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTE       RRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSW       SGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPV       NCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYG       TVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKE       NVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEG       YTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNIS       VCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELENLAVNPSGPGLFL       VDRTLSCRSELARGPIQTLFAWVSAAEGAEQRILVNRKCCCLIIPLEVLSQRNTRPCEVSVRPYWGGN       RERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGT       WSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCE       RRYTQQPKSLNFQLAAYCSIRMFILRGGVQDGQLETAVAGASHREEQKQKREKARWYNGPPGSHMGQA       ELPPPAKGGGPPCGNFSNSSQGFMNRPLISLRWSPWGSMWPWSPQISRLSPSPAGSEESRQAGLVGFP       TAQFTCSAKGQLERFVKRVPDPMPPDWDETPPQQGSRMRPPHNRGHQTPYTRVFLLASGQCPSGTELP       EERAGSHLCCSAASAGKAQNWAEARIDELKEVGFRYWVIMKFAELKEHVLNQCKDAKNQDKTLQDPLT       RITSLERNVNDLMELKNTTRELHNATTKQGQHSSSGNPENPSKILHEKINPKTHNPQVLQEISCGPPA       HVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGGICQRPNAC       SCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTGRPLSWFVFLVAQAHETPEDIEE       CDLDSEVVAK                                             NOV8i, CG50646-05   SEQ ID NO: 193   11152 bp                             DNA Sequence   ORF Start: ATG at 77   ORF Stop: TAA at 10781                             CAATTGGTCTAGGGTCTCCCCCATTGGAATATCCATCAGTGATGAGAAATACAACGTTTGTTGAGTTT           TCTCTAGCATGAGAAGAATTTGCGCGGCTTGCTGGGGTCTGGCGCTCGTTTCGGGCTGGGCGACCTTT       CAGCAGATGTCCCCGTCGCGCAATTTCAGCTTCCGCCTCTTCCCCGAGACCGCGCCCGGGGCCCCCGG       GAGTATCCCCGCGCCGCCCGCTCCTGGCGACGAAGCGGCGGGGAGCAGAGTGGAGCGGCTGGGCCAGG       CGTTCCGCGTGCGGCTGCTGCGGGAGCTCAGCGAGCGCCTGGAGCTTGTCTTCCTGGTGGATGATTCG       TCCAGCGTGGGCGAAGTCAACTTCCGCAGCGAGCTCATGTTCGTCCGCAAGCTGCTGTCCGACTTCCC       CGTGGTGCCCACGGCCACGCGCGTGGCCATCGTGACCTTCTCGTCCAAGAACTACGTGGTGCCGCGCG       TCGATTACATCTCCACCCGCCGCGCGCGCCAGCACAAGTGCGCGCTGCTCCTCCAAGAGATCCCTGCC       ATCTCCTACCGAGGTGGCGGCACCTACACCAAGGGCGCCTTCCAGCAAGCCGCGCAAATTCTTCTTCA       TGCTAGAGAAAACTCAACAAAAGTTGTATTTCTCATCACTGATGGATATTCCAATGGGGGAGACCCTA       GACCAATTGCAGCGTCACTGCGAGATTCAGGAGTGGAGATCTTCACTTTTGGCATATGGCAAGGGAAC       ATTCGAGAGCTGAATGACATGGCTTCCACCCCAAAGGAGGAGCACTGTTACCTGCTACACAGTTTTGA       AGAATTTGAGGCTTTAGCTCGCCGGGCATTGCATGAAGATCTACCTTCTGGGAGTTTTATTCAAGATG       ATATGGTCCACTGCTCATATCTTTGTGATGAGGGCAAGGACTGCTGTGACCGAATGGGAAGCTGCAAA       TGTGGGACACACACAGGCCATTTTGAGTGCATCTGTGAAAAGGGGTATTACGGGAAAGGTCTGCAGTA       TGAATGCACAGCTTGCCCATCGGGGACATACAAACCTGAAGCCTCACCAGGAGGAATCAGCAGTTGCA       TTCCATGTCCCGATGAAAATCACACCTCTCCACCTGGAAGCACATCCCCTGAAGACTGTGTCTGCAGA       GAGGGATACAGGGCATCTGGCCAGACCTGTGAACTTGTCCACTGCCCTGCCCTGAAGCCTCCCGAAAA       TGGTTACTTTATCCAAAACACTTGCAACAACCACTTCAATGCAGCCTGTGGGGTCCGATGTCACCCTG       GATTTGATCTTGTGGGAAGCAGCATCATCTTATGTCTACCCAATGGTTTGTGGTCCGGTTCAGAGAGC       TACTGCAGAGTAAGAACATGTCCTCATCTCCGCCAGCCGAAACATGGCCACATCAGCTGTTCTACAAG       GGAAATGTTATATAAGACAACATGTTTGGTTGCCTGTGATGAAGGGTACAGACTAGAAGGCAGTGATA       AGCTTACTTGTCAAGGAAACAGCCAGTGGGATGGGCCAGAACCCCGGTGTGTGGAGCGCCACTGTTCC       ACCTTTCAGATGCCCAAAGATGTCATCATATCCCCCCACAACTGTGGCAAGCAGCCAGCCAAATTTGG       GACGATCTGCTATGTAAGTTGCCGCCAAGGGTTCATTTTATCTGGAGTCAAAGAAATGCTGAGATGTA       CCACTTCTGGAAAATGGAATGTCGGAGTTCAGGCAGCTGTGTGTAAAGACGTGGAGGCTCCTCAAATC       AACTGTCCTAAGGACATAGAGGCTAAGACTCTGGAACAGCAAGATTCTGCCAATGTTACCTGGCAGAT       TCCAACAGCTAAAGACAACTCTGGTGAAAAGGTGTCAGTCCGCGTTCATCCAGCTTTCACCCCACCTT       ACCTTTTCCCAATTGGAGATGTTGCTATCGTATACACGGCAACTGACCTATCCGGCAACCAGGCCAGC       TGCATTTTCCATATCAAGGTTATTGATGCAGAACCACCTGTCATAGACTGGTGCAGATCTCCACCTCC       CGTCCAGGTCTCGGAGAAGGTACATGCCGCAAGCTGGGATGAGCCTCAGTTCTCAGACAACTCAGGGG       CTGAATTGGTCATTACCAGAAGTCATACACAAGGAGACCTTTTCCCTCAAGGGGAGACTATAGTACAG       TATACAGCCACTGACCCCTCAGGTAATAACAGGATATGTGATATCCATATTGTCATGAAAGGTTCTCC       CTGTGAAATTCCATTCACACCTGTAAATGGGGATTTTATATGCACTCCAGATAATACTGGAGTCAACT       GTACATTAACTTGCTTGGAGGGCTACGATTTCACAGAAGGGTCTACTGACAAGTATTATTGTGCTTAT       GAAGATGGCGTCTGGAAACCAACATATACCACTGAATGGCCAGACTGTGCCAAAAAACGTTTTGCAAA       CCACGGGTTCAAGTCCTTTGAGATGTTCTACAAAGCAGCTCGTTGTGATGACTCAGATCTGATGAAGA       AGTTTTCTGAAGCATTTGAGACGACCCTGGGAAAAATGGTCCCATCATTTTGTAGTGATGCAGAGGAC       ATTGACTGCAGACTGGAGGAGAACCTGACCAAAAAATATTGCCTAGAATATAATTATGACTATGAAAA       TGGCTTTGCAATTGGTCCAGGTGGCTGGGGTGCAGCTAATAGGCTGGATTACTCTTACGATGACTTCC       TGGACACTGTGCAAGAAACAGCCACAAGCATCGGCAATGCCAAGTCCTCACGGATTAAAAGAAGTGCC       CCATTATCTGACTATAAAATTAAGTTAATTTTTAACATCACAGCTAGTGTGCCATTACCCGATGAAAG       AAATGATACCCTTGAATGGGAAAATCAGCAACGACTCCTTCAGACATTGGAAACTATCACAAATAAAC       TGAAAAGGACTCTCAACAAAGACCCCATGTATTCCTTTCAGCTTGCATCAGAAATACTTATAGCCGAC       AGCAATTCATTAGAAACAAAAAAGGCTTCCCCCTTCTGCAGACCAGGCTCAGTGCTGAGAGGGCGTAT       GTGTGTCAATTGCCCTTTGGGAACCTATTATAATCTGGAACATTTCACCTGTGAAAGCTGCCGGATCG       GATCCTATCAAGATGAAGAAGGGCAACTTGAGTGCAAGCTTTGCCCCTCTGGGATGTACACGGAATAT       ATCCATTCAAGAAACATCTCTGATTGTAAAGCTCAGTGTAAACAAGGCACCTACTCATACAGTGGACT       TGAGACTTGTGAATCGTGTCCACTGGGCACTTATCAGCCAAAATTTGGTTCCCGGAGCTGCCTCTCGT       GTCCAGAAAACACCTCAACTGTGAAAAGAGGAGCCGTGAACATTTCTGCATGTGGAGTTCCTTGTCCA       GAAGGAAAATTCTCGCGTTCTGGGTTAATGCCCTGTCACCCATGTCCTCGTGACTATTACCAACCTAA       TGCAGGGAAGGCCTTCTGCCTGGCCTGTCCCTTTTATGGAACTACCCCATTCGCTGGTTCCAGATCCA       TCACAGAATGTTCAAGTTTTAGTTCAACTTTCTCAGCGGCAGAGGAAAGTGTGGTGCCCCCTGCCTCT       CTTGGACATATTAAAAAGAGGCATGAAATCAGCAGTCAGGCAAGTCATGAATGCTTCTTTAACCCTTG       CCACAATAGTGGAACCTGCCAGCAACTTGGGCGTGGTTATGTTTGTCTCTGTCCACTTGGATATACAG       GTTTAAAGTGTGAAACAGACATCGATGAGTGCAGCCCACTGCCTTGCCTCAACAATGGAGTTTGTAAA       GACCTAGTTGGGGAATTCATTTGTGAGTGCCCATCAGGTTACACAGGTAAGCACTGTGAATTGAACAT       CAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTCATACAGTT       GTAAATGTCAGCCAGGATTTTCAGGCAAAAGGTGTGAAACAGGTATGTATCAACTCAGTGTTATTAAT       AACCTTAATAATGCAGTCTGTGAAGACCAGGTTGGGGGATTCTTGTGCAAATGCCCACCTGGATTTTT       GGGTACCCGATGTGGAAAGAACGTCGATGAGTGTCTCAGTCAGCCATGCAAAAATGGAGCTACCTGTA       AAGACGGTGCCAATAGCTTCAGGTGCCTGTGTGCAGCTGGCTTCACAGGATCACACTGTGAATTGAAC       ATCAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTCATACAG       TTGTAAATGTCAGCCAGGATTTTCAGGCAAAAGGTGTGAAACAGAACAGTCTACAGGCTTTAACCTGG       ATTTTGAAGTTTCTGGCATCTATGGATATGTCATGCTAGATGGCATGCTCCCATCTCTCCATGCTCTA       ACCTGTACCTTCTGGATGAAATCCTCTGACGACATGAACTATGGAACACCAATCTCCTATGCAGTTGA       TAACGGCAGCGACAATACCTTGCTCCTGACTGATTATAACGGGTGGGTTCTTTATGTGAATGGCAGGG       AAAAGATAACAAACTGTCCCTCGGTGAATGATGGCAGATGGCATCATATTGCAATCACTTGGACAAGT       ACTGGTGGAGCCTGGAGGGTCTATATAAATGGGGAATTATCTGACGGTGGTACTGGCCTCTCCATTGG       CAAAGCCATACCTGGTGGCGGTGCATTAGTTCTTGGGCAAGAGCAAGACAAAAAAGGAGAGGGGTTCA       ACCCGGCTGAGTCTTTTGTGGGCTCCATAAGCCAGCTCAACCTCTGGGACTATGTCCTGTCTCCACAG       CAGGTGAAGTCACTGGCTACCTCCTGCCCAGAGGAACTCAGTAAAGGAAACGTGTTAGCATGGCCTGA       TTTCTTGTCAGGAATTGTGGGGAAAGTGAAGATCGATTCTAAGAGCATATTTTGTTCTGATTGCCCAC       GCTTGGGAGGGTCAGTGCCTCATCTGAGAACTGCATCTGAAGATTTAAAACCAGGTTCCAAAGTCAAT       CTGTTCTGTGAACCAGGCTTCCAGCTGGTCGGGAACCCTGTGCAGTACTGTCTGAATCAAGGACAGTG       GACACAACCACTCCCCCACTGTGAACGCATTCGCTGTGGGGTGCCACCTCCTTTGGAGAATGGCTTCC       ATTCAGCCGATGACTTCTATGCTGGCAGCACAGTAACCTACCAGTGCAACAATGGCTACTATCTATTG       GGTGACTCAAGGATGTTCTGTACAGATAATGGGAGCTGGAACGGCGTTTCACCATCCTGCTTAGATGT       CGATGAGTGTGCAGTTGGATCAGATTGTAGTGAGCATGCTTCTTGCCTGAACGTAGATGGATCCTACA       TATGTTCATGTGTCCCACCGTACACAGGAGATGGGAAAAACTGTGCAGAACCTATAAAATGTAAGGCT       CCAGGAAATCCGGAAAATGGCCACTCCTCAGGTGAGATTTATACAGTAGGTGCCGAAGTCACATTTTC       GTGTCAGGAAGGATACCAGTTGATGGGAGTAACCAAAATCACATGTTTGGAGTCTGGAGAATGGAATC       ATCTAATACCATATTGTAAAGCTGTTTCATGTGGTAAACCGGCTATTCCAGAAAATGGTTGCATTGAG       GAGTTAGCATTTACTTTTGGCAGCAAAGTGACATATAGCTGTAATAAAGGATATACTCTGGCCCGTGA       TAAAGAATCATCCTGTCTTGCTAACAGTTCTTGGAGTCATTCCCCTCCTGTGTGTGAACCAGTGAAGT       GTTCTAGTCCGGAAAATATAAATAATGGAAAATATATTTTGAGTGGGCTTACCTACCTTTCTACTGCA       TCATATTCATGCGATACAGGATACAGCTTACAGGGCCCTTCCATTATTGAATGCACGGCTTCTGGCAT       CTGGGACAGAGCGCCACCTGCCTGTCACCTCGTCTTCTGTGGAGAACCACCTGCCATCAAAGATGCTG       TCATTACGGGGAATAACTTCACTTTCAGGAACACCGTCACTTACACTTGCAAAGAAGGCTATACTCTT       GCTGGTCTTGACACCATTGAATGCCTGGCCGACGGCAAGTGGAGTAGAAGTGACCAGCAGTGCCTGGC       TGTCTCCTGTGATGAGCCACCCATTGTGGACCACGCCTCTCCAGAGACTGCCCATCGGCTCTTTGGAG       ACATTGCATTCTACTACTGCTCTGATGGTTACAGCCTAGCAGACAATTCCCAGCTTCTCTGCAATGCC       CAGGGCAAGTGGGTACCCCCAGAAGGTCAAGACATGCCCCGTTGTATAGCTCATTTCTGTGAAAAACC       TCCATCGGTTTCCTATAGCATCTTGGAATCTGTGAGCAAAGCAAAATTTGCAGCTGGCTCAGTTGTGA       GCTTTAAATGCATGGAAGGCTTTGTACTGAACACCTCAGCAAAGATTGAATGTATGAGAGGTGGGCAG       TGGAACCCTTCCCCCATGTCCATCCAGTGCATCCCTGTGCGGTGTGGAGAGCCACCAAGCATCATGAA       TGGCTATGCAAGTGGATCAAACTACAGTTTTGGAGCCATGGTGGCTTACAGCTGCAACAAGGGGTTCT       ACATCAAAGGGGAAAAGAAGAGCACCTGCGAAGCCACAGGGCAGTGGAGTAGTCCTATACCGACGTGC       CACCCGGTATCTTGTGGTGAACCACCTAAGGTTGAGAATGGCTTTCTGGAGCATACAACTGGCAGGAT       CTTTGAGAGTGAAGTGAGGTATCAGTGTAACCCGGGCTATAAGTCAGTCGGAAGTCCTGTATTTGTCT       GCCAAGCCAATCGCCACTGGCACAGTGAATCCCCTCTGATGTGTGTTCCTCTCGACTGTGGAAAACCT       CCCCCGATCCAGAATGGCTTCATGAAAGGAGAAAACTTTGAAGTAGGGTCCAAGGTTCAGTTTTTCTG       TAATGAGGGTTATGAGCTTGTTGGTGACAGTTCTTGGACATGTCAGAAATCTGGCAAATGGAATAAGA       AGTCAAATCCAAAGTGCATGCCTGCCAAGTGCCCAGAGCCGCCCCTCTTGGAAAACCAGCTAGTATTA       AAGGAGTTGACCACCGAGGTAGGAGTTGTGACATTTTCCTGTAAAGAAGGGCATGTCCTGCAAGGCCC       CTCTGTCCTGAAATGCTTGCCATCCCAGCAATGGAATGACTCTTTCCCTGTTTGTAAGATTGTTCTTT       GTACCCCACCTCCCCTAATTTCCTTTGGTGTCCCCATTCCTTCTTCTGCTCTTCATTTTGGAAGTACT       GTCAAGTATTCTTGTGTAGGTGGGTTTTTCCTAAGAGGAAATTCTACCACCCTCTGCCAACCTGATGG       CACCTGGAGCTCTCCACTGCCAGAATGTGTTCCAGTAGAATGTCCCCAACCTGAGGAAATCCCCAATG       GAATCATTGATGTGCAAGGCCTTGCCTATCTCAGCACAGCTCTCTATACCTGCAAGCCAGGCTTTGAA       TTGGTGGGAAATACTACCACCCTTTGTGGAGAAAATGGTCACTGGCTTGGAGGAAAACCAACATGTAA       AGCCATTGAGTGCCTGAAACCCAAGGAGATTTTGAATGGCAAATTCTCTTACACGGACCTACACTATG       GACAGACCGTTACCTACTCTTGCAACCGAGGCTTTCGGCTCGAAGGTCCCAGTGCCTTGACCTGTTTA       GAGACAGGTGATTGGGATGTAGATGCCCCATCTTGCAATGCCATCCACTGTGATTCCCCACAACCCAT       TGAAAATGGTTTTGTAGAAGGTGCAGATTACAGCTATGGTGCCATAATCATCTACAGTTGCTTCCCTG       GGTTTCAGGTGGCTGGTCATGCCATGCAGACCTGTGAAGAGTCAGGATGGTCAAGTTCCATCCCAACA       TGTATGCCAATAGACTGTGGCCTCCCTCCTCATATAGATTTTGGAGACTGTACTAAACTCAAAGATGA       CCAGGGATATTTTGAGCAAGAAGACGACATGATGGAAGTTCCATATGTGACTCCTCACCCTCCTTATC       ATTTGGGAGCAGTGGCTAAAACCTGGGAAAATACAAAGGAGTCTCCTGCTACACATTCATCAAACTTT       CTGTATGGTACCATGGTTTCATACACCTGTAATCCAGGATATGAACTTCTGGGGAACCCTGTGCTGAT       CTGCTCCTGAAAATGGCTTTTTGCGTTTTACAGAGACTAGCATGGGAAGTGCTGTGCAGTATAGCTGT       AAACCTGGACACATTCTAGCAGGCTCTGACTTAAGGCTTTGTCTAGAGAATAGAAAGTGGAGTGGTGC       CTCCCCACGCTGTGAAGCCATTTCATGCAAAAAGCCAAATCCAGTCATGAATGGATCCATCAAAGGAA       AGGAGAACATGCCAGGATGACAAAAACTGGGATGAGGATGAGCCCATTTGCATTCCTGTGGACTGCAG       TTCACCCCCAGTCTCAGCCAATGGCCAGGTGAGAGGAGACGAGTACACATTCCAAAAAGAGATTGAAT       ACACTTGCAATGAAGGGTTCTTGCTTGAGGGAGCCAGGAGTCGGGTTTGTCTTGCCAATGGAAGTTGG       GGAAGGCCTGGACTATGGCTTCATGAAGGAAGTAACATTCCACTGTCACGAGGGCTACATCTTGCACG       GTGCTCCAAACTCACCTGTCAGTCAGATGGCCAACTGGGATGCAGAGATTCCTCTCTGTAAACCAGTC       AACTGTGGACCTCCTGAAGATCTTGCCCATGGTTTCCCTAATGGTTTTTCCTTTATTCATGGGGGCCA       TATACAGTATCAGTGCTTTCCTGGTTATAAGCTCCATGGAAATTCATCAAGAAGGTGCCTCTCCAATG       GCTCCTGGAGTGGCAGCTCACCTTCCTGCCTGCCTTGCAGATGTTCCACACCAGTAATTGAATATGGA       ACTGTCAATGGGACAGATTTTGACTGTGGAAAGGCAGCCCGGATTCAGTGCTTCAAAGGCTTCAAGCT       CCTAGGACTTTCTGAAATCACCTGTGAAGCCGATGGCCAGTGGAGCTCTGGGTTCCCCCACTGTGAAC       ACACTTCTTGTGGTTCTCTTCCAATGATACCAAATGCGTTCATCAGTGAGACCAGCTCTTGGAAGGAA       AATGTGATAACTTACAGCTGCAGGTCTGGATATGTCATACAAGGCAGTTCAGATCTGATTTGTACAGA       GAAAGGGGTATGGAGCCAGCCTTATCCAGTCTGTGAGCCCTTGTCCTGTGGGTCCCCACCGTCTGTCG       CCAATGCAGTGGCAACTGGAGAGGCACACACCTATGAAAGTGAAGTGAAACTCAGATGTCTGGAAGGT       TATACGATGGATACAGATACAGATACATTCACCTGTCAGAAAGATGGTCGCTGGTTCCCTGAGAGAAT       CTCCTGCAGTCCTAAAAAATGTCCTCTCCCGGAAAACATAACACATATACTTGTACATGGGGACGATT       TCAGTGTGAATAGGCAAGTTTCTGTGTCATGTGCAGAAGGGTATACCTTTGAGGGAGTTAACATATCA       GTATGTCAGCTTGATGGAACCTGGGAGCCACCATTCTCCGATGAATCTTGCAGTCCAGTTTCTTGTGG       GAAACCTGAAAGTCCAGAACATGGATTTGTGGTTGGCAGTAAATACACCTTTGAAAGCACAATTATTT       AGTGGAGGGGTGGCAATATGCAAAGAGACCAGGTGTGAAACTCCACTTGAATTTCTCAATGGGAAAGC       GGCCATCTGAGGCACACTGCACAGAAATGGAACCTGGAGCCACCCAGTCCCTCTCTGCAAACCAAAAT       CCATGCCCTGTTCCTTTTGTGATTCCCGAGAATGCTCTGCTGTCTGAAAAGGAGTTTTATGTTGATCA       AATGCAATTGCTCGAGGCGTACATTATCAATATGGAGACATGATCACCTACTCATGTTACAGTGGATA       CATGTTGGAGGGTTTCCTGAGGAGTGTTTGTTTAGAAAATGGAACATGGACATCACCTCCTATTTGCA       GAGCTGTCTGTCGATTTCCATGTCAGAATGGGGGCATCTGCCAACGCCCAAATGCTTGTTCCTGTCCA       GAGGGCTGGATGGGGCGCCTCTGTGAAGAACCAATCTGCATTCTTCCCTGTCTGAACGGAGGTCGCTG       TGTGGCCCCTTACCAGTGTGACTGCCCGCCTGGCTGGACGGGGTCTCGCTGTCATACAGCTGTTTGCC       AGTCTCCCTGCTTAAATGGTGGAAAATGTGTAAGACCAAACCGATGTCACTGTCTTTCTTCTTGGACG       GGACATAACTGTTCCAGGAAAAGGAGGACTGGGTTTTAACCACTGCACGACCATCTGGCTCTCCCAAA       AGCAGGATCATCTCTCCTCGGTAGTGCCTGGGCATCCTGGAACTTATGCAAAGAAAGTCCAACATGGT       GCTGGGTCTTGTTTAGTAAACTTGTTACTTGGGGTTACTTTTTTTATTTTGTGATATATTTTGTTATT       CCTTGTGACATACTTTCTTACATGTTTCCATTTTTAAATATGCCTGTATTTTCTATATAAAAATTATA       TTAAATAGATGCTGCTCTACCCTCACAAAATGTACATATTCTGCTGTCTATTGGGAAAGTTCCTGGTA       CACATTTTTATTCAGTTACTTAAAATGATTTTTCCATTAAAGTATATTTTGCTACTAAATAAAAAAAA                                         NOV8i, CG50646-05                                     Protein Sequence   SEQ ID NO: 194   3568 aa   MW at 389944.3kD                             MPRICAACWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRVERLGQAFR           VRLLRELSERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRVDY       ISTRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPI       AASLRDSGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMV       HCSYLCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEASPGGISSCIPC       PDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFD       LVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYPLEGSDKLT       CQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTS       GKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEKVSVRVHPAFTPPYLF       PIGDVAIVYTATDLSGNQASCIFRIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWDEPQFSDNSGAEL       VITRSHTQGDLFPQGETIVQYTATDPSGNNRICDIHIVMKGSPCEIPFTPVNGDFICTPDNTGVNCTL       TCLEGYDFTEGSTDKYYCAYEDGVWKPTYTTEWPDCAKKRFANHGFKSFEMFYKAARCDDSDLMKKFS       EAFETTLGKMVPSFCSDAEDIDCRLEENLTKKYCLEYNYDYENGFAIGPGGWGAANRLDYSYDDFLDT       VQETATSIGNAKSSRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKLKR       TLNKDPMYSFQLASEILIADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRIGSY       QDEEGQLECKLCPSGMYTEYIRSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSCPE       NTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSITE       CSSFSSTFSAAEESVVPPASLGHIKKRHEISSQASHECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLK       CETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGKHCELNINECQSNPCRNQATCVDELNSYSCKC       QPGFSGKRCETGMYQLSVINNLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDG       ANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLDFE       VSGIYGYVMLDGMLPSLHALTCTFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGREKI       TNCPSVNDGRWHHIAITWTSTGGAWRVYINGELSDGGTGLSIGKAIPGGGALVLGQEQDKKGEGFNPA       ESFVGSISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPRLG       GSVPHLRTASEDLKPGSKVNLFCEPGFQLVGNPVQYCLNQGQWTQPLPHCERIRCGVPPPLENGFHSA       DDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICS       CVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLI       PYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSS       PENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVIT       GNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIA       FYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFK       CMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIK       GEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQA       NRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSN       PKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTP       PPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGII       DVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQT       VTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQ       VAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLG       AVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAP       ENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSNY       TYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTC       NEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILRGAP       KLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSW       SGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTS       CGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANA       VATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSV       NRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQC       EPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPS       EAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDET       WTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAV       CRFPCQNGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQSP       CLNGGKCVRPNRCHCLSSWTGHNCSRKRRTGF                                                 SEQ ID NO: 195   11158 bp                                 NOV8j, SNP13380898 of   ORF Start: ATG at 77   ORF Stop: TAA at 10787                             CG50646-04, DNA Sequence   SNP Pos: 1068   SNP Change: G to C                             CAATTGGTCTAGGGTCTCCCCCATTGGAATATCCATCAGTGATGAGAAATACAACGTTTGTTGAGTTT           TCTCTAGCATGAGAAGAATTTGCGCGGCTTGCTGGGGTCTGGCGCTCGTTTCGGGCTGGGCGACCTTT       CAGCAGATGTCCCCGTCGCGCAATTTCAGCTTCCGCCTCTTCCCCGAGACCGCGCCCGGGGCCCCCGG       GAGTATCCCCGCGCCGCCCGCTCCTGGCGACGAAGCGGCGGGGAGCAGAGTGGAGCGGCTGGGCCAGG       CGTTCCGCGTGCGGCTGCTGCGGGAGCTCAGCGAGCGCCTGGAGCTTGTCTTCCTGGTGGATGATTCG       TCCAGCGTGGGCGAAGTCAACTTCCGCAGCGAGCTCATGTTCGTCCGCAAGCTGCTGTCCGACTTCCC       CGTGGTGCCCACGGCCACGCGCGTGGCCATCGTGACCTTCTCGTCCAAGAACTACGTGGTGCCGCGCG       TCGATTACATCTCCACCCGCCGCGCGCGCCAGCACAAGTGCGCGCTGCTCCTCCAAGAGATCCCTGCC       ATCTCCTACCGAGGTGGCGGCACCTACACCAAGGGCGCCTTCCAGCAAGCCGCGCAAATTCTTCTTCA       TGCTAGAGAAAACTCAACAAAAGTTGTATTTCTCATCACTGATGGATATTCCAATGGGGGAGACCCTA       GACCAATTGCAGCGTCACTGCGAGATTCAGGAGTGGAGATCTTCACTTTTGGCATATGGCAAGGGAAC       ATTCGAGAGCTGAATGACATGGCTTCCACCCCAAAGGAGGAGCACTGTTACCTGCTACACAGTTTTGA       AGAATTTGAGGCTTTAGTCGCCCTCTGTCATATGTTATTTGTAGATCTACCTTCTGGGAGTTTTATTC       AAGATGATATGGTCCACTGCTCATATCTTTGTGATGAAGGCAAGGACTGCTGTGACCGAATGGGAAGC       TGCAAATGTGGGAAACACACAGGCCATTTTGAGTGCATCTGTGAAAAGGGGTATAACGGGAAAGGTCT       GCAGTATGACTGCACAGTTTGCCCATCGGGGACATACAAACCTGAAGCCTCACCAGGAGGAATCAGCA       GTTGCATTCCATGTCCTGATGAAAATCACACCTCTCCACCTGGAAGCACATCCCCTGAAGACTGTGTC       TGCAGAGAGGGATACAGGGCATCTGGCCAGACCTGTGAAGTTGTCCACTGCCCTGCCCTGAAGCCTCC       CGAAAATGGTTACTTTATCCAAAACACTTGCAACAACCACTTCAATGCAGCCTGTGGGGTCCGATGTC       ACCCTGGATTTGATCTTGTGGGAAGCAGCATCATCTTATGTCTACCCAATGGTTTGTGGTCCGGTTCA       GAGAGCTACTGCAGAGTAAGAACATGTCCTCATCTCCGCCAGCCGAAACATGGCCACATCAGCTGTTC       TACAAGGGAAATGTTATATAAGACAACATGTTTGGTTGCCTGTGATGAAGGGTACAGGCTAGAAGGCA       GTGATAAGCTTACTTGTCAAGGAAACAGCCAGTGGGATGGGCCAGAACCCCGGTGTGTGGAGCGCCAC       TGTTCCACCTTTCAGATGCCCAAAGATGTCATCATATCCCCCCACAACTGTGGCAAGCAGCCAGCCAA       ATTTGGGACGATCTGCTATGTAAGTTGCCGCCAAGGGTTCATTTTATCTGGAGTCAAAGAAATGCTGA       CAAATCAACTGTCCTAAGGACATAGAGGCTAAGACTCTGGAACAGCAAGATTCTGCCAATGTTACCTG       GCAGATTCCAACAGCTAAAGACAACTCTGGTGAAAAGGTGTCAGTCCACGTTCATCCAGCTTTCACCC       CACCTTACCTTTTCCCAATTGGAGATGTTGCTATCGTATACACGGCAACTGACCTATCCGGCAACCAG       GCCAGCTGCATTTTCCATATCAAGGTTATTGATGCAGAACCACCTGTCATAGACTGGTGCAGATCTCC       ACCTCCCGTCCAGGTCTCGGAGAAGGTACATGCCGCAAGCTGGGATGAGCCTCAGTTCTCAGACAACT       CAGGTGCTGAATTGGTCATTACCAGAAGTCATACACAAGGAGACCTTTTCCCTCAAGGGGAGACTATA       GTACAGTATACAGCCACTGACCCCTCAGGCAATAACAGGACATGTGATATCCATATTGTCATAAAAGG       TTCTCCCTGTGAAATTCCATTCACACCTGTAAATGGGGATTTTATATGCACTCCAGATAATACTGGAG       TCAACTGTACATTAACTTGCTTGGAGGGCTATGATTTCACAGAAGGGTCTACTGACAAGTATTATTGT       GCTTATGAAGATGGCGTCTGGAAACCAACATATACCACTGAATGGCCAGACTGTGCCAGTAAGCGTTT       TGCAAACCACGGGTTCAAGTCCTTTGAGATGTTCTACAAAGCAGCTCGTTGTGATGACACAGATCTGA       TGAAGAAGTTTTCTGAAGCATTTGAGACGACCCTGGGAAAAATGGTCCCATCATTTTGTAGTGATGCA       GAGGACATTGACTGCAGACTGGAGGAGAACCTGACCAAAAAATATTGCCTAGAATATAATTATGACTA       TGAAAATGGCTTTGCAATTGGTCCAGGTGGCTGGGGTGCAGCTAATAGGCTGGATTACTCTTACGATG       ACTTCCTGGACACTGTGCAAGAAACAGCCACAAGCATCGGCAATGCCAAGTCCTCACGGATTAAAAGA       AGTGCCCCATTATCTGACTATAAAATTAAGTTAATTTTTAACATCACAGCTAGTGTGCCATTACCCGA       TGAAAGAAATGATACCCTTGAATGGGAAAATCAGCAACGACTCCTTCAGACATTGGAAACTATCACAA       ATAAACTGAAAAGGACTCTCAACAAAGACCCCATGTATTCCTTTCAGCTTGCATCAGAAATACTTATA       GCCGACAGCAATTCATTAGAAACAAAAAAGGCTTCCCCCTTCTGCAGACCAGGCTCAGTGCTGAGAGG       GCGTATGTGTGTCAATTGCCCTTTGGGAACCTATTATAATCTGGAACATTTCACCTGTGAAAGCTGCC       GGATCGGATCCTATCAAGATGAAGAAGGGCAACTTGAGTGCAAGCTTTGCCCCTCTGGGATGTACACG       GAATATATCCATTCAAGAAACATCTCTGATTGTAAAGCTCAGTGTAAACAAGGCACCTACTCATACAG       TGGACTTGAGACTTGTGAATCGTGTCCACTGGGCACTTATCAGCCAAAATTTGGTTCCCGGAGCTGCC       TCTCGTGTCCAGAAAACACCTCAACTGTGAAAAGAGGAGCCGTGAACATTTCTGCATGTGGAGTTCCT       TGTCCAGAAGGAAAATTCTCGCGTTCTGGGTTAATGCCCTGTCACCCATGTCCTCGTGACTATTACCA       ACCTAATGCAGGGAAGGCCTTCTGCCTGGCCTGTCCCTTTTATGGAACTACCCCATTCGCTGGTTCCA       GATCCATCACAGAATGTTCAAGTTTTAGTTCAACTTTCTCAGCGGCAGAGGAAAGTGTGGTGCCCCCT       GCCTCTCTTGGACATATTAAAAAGAGGCATGAAATCAGCAGTCAGGCAAGTCATGAATGCTTCTTTAA       CCCTTGCCACAATAGTGGAACCTGCCAGCAACTTGGGCGTGGTTATGTTTGTCTCTGTCCACTTGGAT       ATACAGGTTTAAAGTGTGAAACAGACATCGATGAGTGCAGCCCACTGCCTTGCCTCAACAATGGAGTT       TGTAAAGACCTAGTTGGGGAATTCATTTGTGAGTGCCCATCAGGTTACACAGGTAAGCACTGTGAATT       GAACATCAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTCAT       ACAGTTGTAAATGTCAGCCAGGATTTTCAGGCAAAAGGTGTGAAACAGGTATGTATCAACTCAGTGTT       ATTAATAACCTTAATAATGCAGTCTGTGAAGACCAGGTTGGGGGATTCTTGTGCAAATGCCCACCTGG       ATTTTTGGGTACCCGATGTGGAAAGAACGTCGATGAGTGTCTCAGTCAGCCATGCAAAAATGGAGCTA       CCTGTAAAGACGGTGCCAATAGCTTCAGGTGCCTGTGTGCAGCTGGCTTCACAGGATCACACTGTGAA       TTGAACATCAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTC       ATACAGTTGTAAATGTCAGCCAGGATTTTCAGGCAAAAGGTGTGAAACAGAACAGTCTACAGGCTTTA       ACCTGGATTTTGAAGTTTCTGGCATCTATGGATATGTCATGCTAGATGGCATGCTCCCATCTCTCCAT       GCTCTAACCTGTACCTTCTGGATGAAATCCTCTGACGACATGAACTATGGAACACCAATCTCCTATGC       AGTTGATAACGGCAGCGACAATACCTTGCTCCTGACTGATTATAACGGGTGGGTTCTTTATGTGAATG       GCAGGGAAAAGATAACAAACTGTCCCTCGGTGAATGATGGCAGATGGCATCATATTGCAATCACTTGG       ACAAGTACTGGTGGAGCCTGGAGGGTCTATATAAATGGGGAATTATCTGACGGTGGTACTGGCCTCTC       CATTGGCAAAGCCATACCTGGTGGCGGTGCATTAGTTCTTGGGCAAGAGCAAGACAAAAAAGGAGAGG       GGTTCAACCCGGCTGAGTCTTTTGTGGGCTCCATAAGCCAGCTCAACCTCTGGGACTATGTCCTGTCT       GCCTGATTTCTTGTCAGGAATTGTGGGGAAAGTGAAGATCGATTCTAAGAGCATATTTTGTTCTGATT       GCCCACGCTTGGGAGGGTCAGTGCCTCATCTGAGAACTGCATCTGAAGATTTAAAACCAGGTTCCAAA       GTCAATCTGTTCTGTGAACCAGGCTTCCAGCTGGTCGGGAACCCTGTGCAGTACTGTCTGAATCAAGG       ACAGTGGACACAACCACTCCCCCACTGTGAACGCATTCGCTGTGGGGTGCCACCTCCTTTGGAGAATG       GCTTCCATTCAGCCGATGACTTCTATGCTGGCAGCACAGTAACCTACCAGTGCAACAATGGCTACTAT       CTATTGGGTGACTCAAGGATGTTCTGTACAGATAATGGGAGCTGGAACGGCGTTTCACCATCCTGCTT       AGATGTCGATGAGTGTGCAGTTGGATCAGATTGTAGTGAGCATGCTTCTTGCCTGAACGTAGATGGAT       CCTACATATGTTCATGTGTCCCACCGTACACAGGAGATGGGAAAAACTGTGCAGAACCTATAAAATGT       AAGGCTCCAGGAATCCGGAAATCCGGCCACTCCTCAGGTGAGATTTATACAGTAGGTGCCGAAGTCAC       ATTTTCGTGTCAGGAAGGATACCAGTTGATGGGAGTAACCAAAATCACATGTTTGGAGTCTGGAGAAT       GGAATCATCTAATACCATATTGTAAAGCTGTTTCATGTGGTAAACCGGCTATTCCAGAAAATGGTTGC       ATTGAGGAGTTAGCATTTACTTTTGGCAGCAAAGTGACATATAGGTGTAATAAAGGATATACTCTGGC       CGGTGATAAAGAATCATCCTGTCTTGCTAACAGTTCTTGGAGTCATTCCCCTCCTGTGTGTGAACCAG       TGAAGTGTTCTAGTCCGGAAAATATAAATAATGGAAAATATATTTTGAGTGGGCTTACCTACCTTTCT       ACTGCATCATATTCATGCGATACAGGATACAGCTTACAGGGCCCTTCCATTATTGAATGCACGGCTTC       TGGCATCTGGGACAGAGCGCCACCTGCCTGTCACCTCGTCTTCTGTGGAGAACCACCTGCCATCAAAG       ATGCTGTCATTACGGGGAATAACTTCACTTTCAGGAACACCGTCACTTACACTTGCAAAGAAGGCTAT       ACTCTTGCTGGTCTTGACACCATTGAATGCCTGGCCGACGGCAAGTGGAGTAGAAGTGACCAGCAGTG       CCTGGCTGTCTCCTGTGATGAGCCACCCATTGTGGACCACGCCTCTCCAGAGACTGCCCATCGGCTCT       TTGGAGACATTGCATTCTACTACTGCTCTGATGGTTACAGCCTAGCAGACAATTCCCAGCTTCTCTGC       AATGCCCAGGGCAAGTGGGTACCCCCAGAAGGTCAAGACATGCCCCGTTGTATAGCTCATTTCTGTGA       AAAACCTCCATCGGTTTCCTATAGCATCTTGGAATCTGTGAGCAAAGCAAAATTTGCAGCTGGCTCAG       TTGTGAGCTTTAAATGCATGGAAGGCTTTGTACTGAACACCTCAGGLAAGATTGAATGTATGAGAGGT       GGGCAGTGGAACCCTTCCCCCATGTCCATCCAGTGCATCCCTGTGCGGTGTGGAGAGCCACCAAGCAT       CATGAATGGCTATGCAAGTGGATCAAACTACAGTTTTGGAGCCATGGTGGCTTACAGCTGCAACAAGG       GGTTCTACATCAAAGGGGAAAAGAAGAGCACCTGCGAAGCCACAGGGCAGTGGAGTAGTCCTATACCG       ACGTGCCACCCGGTATCTTGTGGTGAACCACCTAAGGTTGAGAATGGCTTTCTGGAGCATACAACTGG       CAGGATCTTTGAGAGTGAAGTGAGGTATCAGTGTAACCCGGGCTATAAGTCAGTCGGAAGTCCTGTAT       TTGTCTGCCAAGCCAATCGCCACTGGCACAGTGAATCCCCTCTGATGTGTGTTCCTCTCGACTGTGGA       AAACCTCCCCCGATCCAGAATGGCTTCATGAAAGGAGALAACTTTGAAGTAGGGTCCAAGGTTCAGTT       TTTCTGTAATGAGGGTTATGAGCTTGTTGGTGACAGTTCTTGGACATGTCAGAAATCTGGCAAATGGA       ATAAGAAGTCAAATCCAAAGTGCATGCCTGCCAAGTGCCCAGAGCCGCCCCTCTTGGAAAACCAGCTA       GTATTAAAGGAGTTGACCACCGAGGTAGGAGTTGTGACATTTTCCTGTAAAGAAGGGCATGTCCTGCA       AGGCCCCTCTGTCCTGAAATGCTTGCCATCCCAGCAATGGAATGACTCTTTCCCTGTTTGTAAGATTG       TTCTTTGTACCCCACCTCCCCTAATTTCCTTTGGTGTCCCCATTCCTTCTTCTGCTCTTCATTTTGGA       AGTACTGTCAAGTATTCTTGTGTAGGTGGGTTTTTCCTAAGAGGAAATTCTACCACCCTCTGCCAACC       TGATGGCACCTGGAGCTCTCCACTGCCAGAATGTGTTCCAGTAGAATGTCCCCAACCTGAGGAAATCC       CCAATGGAATCATTGATGTGCAAGGCCTTGCCTATCTCAGCACAGCTCTCTATACCTGCAAGCCAGGC       TTTGAATTGGTGGGAAATACTACCACCCTTTGTGGAGAAAATGGTCACTGGCTTGGAGGAAAACCAAC       ATGTAAAGCCATTGAGTGCCTGAAACCCAAGGAGATTTTGAATGGCAAATTCTCTTACACGGACCTAC       ACTATGGACAGACCGTTACCTACTCTTGCAACCGAGGCTTTCGGCTCGAAGGTCCCAGTGCCTTGACC       TGTTTAGAGACAGGTGATTGGGATGTAGATGCCCCATCTTGCAATGCCATCCACTGTGATTCCCCACA       ACCCATTGAAAATGGTTTTGTAGAAGGTGCAGATTACAGCTATGGTGCCATAATCATCTACAGTTGCT       TCCCTGGGTTTCAGGTGGCTGGTCATGCCATGCAGACCTGTGAAGAGTCAGGATGGTCAAGTTCCATC       CCAACATGTATGCCAATAGACTGTGGCCTCCCTCCTCATATAGATTTTGGAGACTGTACTAAACTCAA       AGATGACCAGGGATATTTTGAGCAAGAAGACGACATGATGGAAGTTCCATATGTGACTCCTCACCCTC       CTTATCATTTGGGAGCAGTGGCTAAAACCTGGGAAAATACAAAGGAGTCTCCTGCTACACATTCATCA       AACTTTCTGTATGGTACCATGGTTTCATACACCTGTAATCCAGGATATGAACTTCTGGGGAACCCTGT       GCTGATCTGCCAGGAAGATGGAACTTGGAATGGCAGTGCACCATCCTGCATTTCAATTGAATGTGACT       TGCCTACTGCTCCTGAAAATGGCTTTTTGCGTTTTACAGAGACTAGCATGGGAAGTGCTGTGCAGTAT       AGCTGTAAACCTGGACACATTCTAGCAGGCTCTGACTTAAGGCTTTGTCTAGAGAATAGAAAGTGGAG       TGGTGCCTCCCCACGCTGTGAAGCCATTTCATGCAAAAAGCCAAATCCAGTCATGAATGGATCCATCA       AAGGAAGCAACTACACATACCTGAGCACGTTGTACTATGAGTGTGACCCCGGATATGTGCTGAATGGC       ACTGAGAGGAGAACATGCCAGGATGACAAAAACTGGGATGAGGATGAGCCCATTTGCATTCCTGTGGA       CTGCAGTTCACCCCCAGTCTCAGCCAATGGCCAGGTGAGAGGAGACGAGTACACATTCCAAAAAGAGA       TTGAATACACTTGCAATGAAGGGTTCTTGCTTGAGGGAGCCAGGAGTCGGGTTTGTCTTGCCAATGGA       AGTTGGAGTGGAGCCACTCCCGACTGTGTGCCTGTCAGATGTGCCACCCCGCCACAACTGGCCAATGG       GGTGACGGAAGGCCTGGACTATGGCTTCATGAAGGAAGTAACATTCCACTGTCACGAGGGCTACATCT       TGCACGGTGCTCCAAACTCACCTGTCAGTCAGATGGCAACTGGGATGCAGAGATTCCTCTCTGTAAAA       CCAGTCAACTGTGGACCTCCTGAAGATCTTGCCCATGGTTTCCCTAATGGTTTTTCCTTTATTCATGG       GGGCCATATACAGTATCAGTGCTTTCCTGGTTATAAGCTCCATGGAAATTCATCAAGAAGGTGCCTCT       CCAATGGCTCCTGGAGTGGCAGCTCACCTTCCTGCCTGCCTTGCAGATGTTCCACACCAGTAATTGAA       TATGGAACTGTCAATGGGACAGATTTTGACTGTGGAAAGGCAGCCCGGATTCAGTGCTTCAAAGGCTT       CAAGCTCCTAGGACTTTCTGAAATCACCTGTGAAGCCGATGGCCAGTGGAGCTCTGGGTTCCCCCACT       GTGAACACACTTCTTGTGGTTCTCTTCCAATGATACCAAATGCGTTCATCAGTGAGACCAGCTCTTGG       AAGGAAAATGTGATAACTTACAGCTGCAGGTCTGGATATGTCATACAAGGCAGTTCAGATCTGATTTG       TACAGAGAAAGGGGTATGGAGCCAGCCTTATCCAGTCTGTGAGCCCTTGTCCTGTGGGTCCCCACCGT       CTGTCGCCAATGCAGTGGCAACTGGAGAGGCACACACCTATGAAAGTGAAGTGAAACTCAGATGTCTG       GAAGGTTATACGATGGATACAGATACAGATACATTCACCTGTCAGAAAGATGGTCGCTGGTTCCCTGA       GAGAATCTCCTGCAGTCCTAAAAAATGTCCTCTCCCGGAAAACATAACACATATACTTGTACATGGGG       ACGATTTCAGTGTGAATAGGCAAGTTTCTGTGTCATGTGCAGAAGGGTATACCTTTGAGGGAGTTAAC       ATATCAGTATGTCAGCTTGATGGAACCTGGGAGCACCATTCTCCGATGCAGTCTTGCAGTCCAGTTTC       TTGTGGGAAACCTGAAAGTCCAGAACATGGATTTGTGGTTGGCAGTAAATACACCTTTGAAAGCACAA       TTATTTATCAGTGTGAGCCTGGCTATGAACTAGAGGGGAACAGGGAACGTGTCTGCCAGGAGAACAGA       CAGTGGAGTGGAGGGGTGGCAATATGCAAAGAGACCAGGTGTGAAACTCCACTTGAATTTCTCAATGG       GAAAGCTGACATTGAAAACAGGACGACTGGACCCAACGTGGTATATTCCTGCAACAGAGGCTACAGTC       TTGAAGGGCCATCTGAGGCACACTGCACAGAAAATGGAACCTGGAGCCACCCAGTCCCTCTCTGCAAA       CCAAATCCATGCCCTGTTCCTTTTGTGATTCCCGAGAATGCTCTGCTGTCTGAAAAGGAGTTTTATGT       TGATCAGAATGTGTCCATCAAATGTAGGGAAGGTTTTCTGCTGCAGGGCCACGGCATCATTACCTGCA       ACCCCGACGAGACGTGGACACAGACAAGCGCCAAATGTGAAAAAATCTCATGTGGTCCACCAGCTCAC       GTAGAAAATGCAATTGCTCGAGGCGTACATTATCAATATGGAGACATGATCACCTACTCATGTTACAG       TGGATACATGTTGGAGGGTTTCCTGAGGAGTGTTTGTTTAGAAAATGGAACATGGACATCACCTCCTA       TTTGCAGAGCTGTCTGTCGATTTCCATGTCAGAATGGGGGCATCTGCCAACGCCCAAATGCTTGTTCC       TGTCCAGAGGGCTGGATGGGGCGCCTCTGTGAAGAACCAATCTGCATTCTTCCCTGTCTGAACGGAGG       TCGCTGTGTGGCCCCTTACCAGTGTGACTGCCCGCCTGGCTGGACGGGGTCTCGCTGTCATACAGCTG       TTTGCCAGTCTCCCTGCTTAAATGGTGGAAAATGTGTAAGACCAAACCGATGTCACTGTCTTTCTTCT       TGGACGGGACATAACTGTTCCAGGAAAAGGAGGACTGGGTTTTAACCACTGCACGACCATCTGGCTCT       CCCAAAAGCAGGATCATCTCTCCTCGGTAGTGCCTGGGCATCCTGGAACTTATGCAAAGAAAGTCCAA       CATGGTGCTGGGTCTTGTTTAGTAAACTTGTTACTTGGGGTTACTTTTTTTATTTTGTGATATATTTT       ATTATATTAAATAGATGCTGCTCTACCCTCACAAAATGTACATATTCTGCTGTCTATTGGGAAAGTTC       CTGGTACACATTTTTATTCAGTTACTTAAAATGATTTTTCCATTAAAGTATATTTTGCTACTAAATAA       AAAAAA                                         NOV8j, SNP13380898 of                                         CG50646-04, Protein   SEQ ID NO: 196       MW at 390026.5kD                                 Sequence   SNP Pos: 331   3570 aa   SNP Change: Gly to Ala                             MRRICAACWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRVERLGQAFR           VRLLRELSERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRVDY       ISTRRARQHKCALLLQEIPAlSYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPI       AASLRDSGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALVALCHMLFVDLPSGSFIQDD       MVHCSYLCDEGKDCCDRMGSCKCGKHTGHFECICEKGYNGKGLQYDCTVCPSGTYKPEASPGGISSCI       PCPDENHTSPPGSTSPEDCVCREGYFASGQTCEVVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPG       FDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYPLEGSDK       LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCT       TSGWNNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEKVSVHVHPAFTPPY       LFPIGDVAIVYTATDLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWDEPQFSDNSGA       ELVITRSHTQGDLFPQGETIVQYTATDPSGNNRTCDIHIVIKGSPCEIPFTPVNGDFICTPDNTGVNC       TLTCLEGYDFTEGSTDKYYCAYEDGVWKPTYTTEWPDCASKRFANHGFKSFEMFYKAARCDDTDLMKK       FSEAFETTLGKMVPSFCSDAEDIDCRLEENLTKKYCLEYNYDYENGFAIGPGGWGAANRLDYSFDDFL       DTVQETATSIGNAKSSRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKL       KRTLNKDPMYSFQLASEILIADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRIG       SYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSC       PENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSI       TECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQASHECFFNPCHNSGTCQQLGRGYVCLCPLGYTG       LKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGKHCELNINECQSNPCRNQATCVDELNSYSC       KCQPGFSGKRCETGMYQLSVINNLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCK       DGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLD       FEVSGIYGYVMLDGMLPSLHAITCTFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGRE       KITNCPSVNDGRWHHIAITWTSTGGAWRVYINGELSDGGTGLSIGKAIPGGGALVLGQEQDKKGEGFN       PAESFVGSISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPR       LGGSVPHLRTASEDLKPGSKVNLFCEPGFQLVGNPVQYCLNQGQWTQPLPHCERIRCGVPPPLENGFH       SADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYI       CSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNH       LIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKC       SSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAV       ITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGD       IAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVS       FKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFY       IKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVC       QANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKK       SNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLC       TPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNG       IIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYG       QTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPG       FQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYH       LGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPT       APENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGS       NYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEY       TCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHG       APKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNG       SWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEH       TSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVA       NAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDF       SVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIY       QCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEG       PSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPD       ETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICR       AVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQ       SPCLNGGKCVRPNRCHCLSSWTGHNCSRKRRTGF                                             NOV8k, SNP13380899 of   SEQ ID NO: 197   11158 bp           CG50646-04,   ORF Start: ATG at 77   ORF Stop: TAA at 10787                             DNA Sequence   SNP Pos: 2404   SNP Change: A to G                             CAATTGGTCTAGGGTCTCCCCCATTGGAATATCCATCAGTGATGAGAAATACAACGTTTGTTGAGTTT           TCTCTAGCATGAGAAGAATTTGCGCGGCTTGCTGGGGTCTGGCGCTCGTTTCGGGCTGGGCGACCTTT       CAGCAGATGTCCCCGTCGCGCAATTTCAGCTTCCGCCTCTTCCCCGAGACCGCGCCCGGGGCCCCCGG       GAGTATCCCCGCGCCGCCCGCTCCTGGCGACGAAGCGGCGGGGAGCAGAGTGGAGCGGCTGGGCCAGG       CGTTCCGCGTGCGGCTGCTGCGGGAGCTCAGCGAGCGCCTGGAGCTTGTCTTCCTGGTGGATGATTCG       TCCAGCGTGGGCGAAGTCAACTTCCGCAGCGAGCTCATGTTCGTCCGCAAGCTGCTGTCCGACTTCCC       CGTGGTGCCCACGGCCACGCGCGTGGCCATCGTGACCTTCTCGTCCAAGAACTACGTGGTGCCGCGCG       TCGATTACATCTCCACCCGCCGCGCGCGCCAGCACAAGTGCGCGCTGCTCCTCCAAGAGATCCCTGCC       ATCTCCTACCGAGGTGGCGGCACCTACACCAAGGGCGCCTTCCAGCAAGCCGCGCAAATTCTTCTTCA       TGCTAGAGAAAACTCAACAAAAGTTGTATTTCTCATCACTGATGGATATTCCAATGGGGGAGACCCTA       GACCAATTGCAGCGTCACTGCGAGATTCAGGAGTGGAGATCTTCACTTTTGGCATATGGCAAGGGAAC       ATTCGAGAGCTGAATGACATGGCTTCCACCCCAAAGGAGGAGCACTGTTACCTGCTACACAGTTTTGA       AGAATTTGAGGCTTTAGTCGCCCTCTGTCATATGTTATTTGTAGATCTACCTTCTGGGAGTTTTATTC       AAGATGATATGGTCCACTGCTCATATCTTTGTGATGAAGGCAAGGACTGCTGTGACCGAATGGGAAGC       TGCAAATGTGGGAAACACACAGGCCATTTTGAGTGCATCTGTGAAAAGGGGTATAACGGGAAAGGTCT       GCAGTATGACTGCACAGTTTGCCCATCGGGGACATACAAACCTGAAGGCTCACCAGGAGGAATCAGCA       GTTGCATTCCATGTCCTGATGAAAATCACACCTCTCCACCTGGAAGCACATCCCCTGAAGACTGTGTC       TGCAGAGAGGGATACAGGGCATCTGGCCAGACCTGTGAAGTTGTCCACTGCCCTGCCCTGAAGCCTCC       CGAAAATGGTTACTTTATCCAAAACACTTGCAACAACCACTTCAATGCAGCCTGTGGGGTCCGATGTC       ACCCTGGATTTGATCTTGTGGGAAGCAGCATCATCTTATGTCTACCCAATGGTTTGTGGTCCGGTTCA       GAGAGCTACTGCAGAGTAAGAACATGTCCTCATCTCCGCCAGCCGAAACATGGCCACATCAGCTGTTC       TACAAGGGAAATGTTATATAAGACAACATGTTTGGTTGCCTGTGATGAAGGGTACAGGCTAGAAGGCA       GTGATAAGCTTACTTGTCAAGGAAACAGCCAGTGGGATGGGCCAGAACCCCGGTGTGTGGAGCGCCAC       TGTTCCACCTTTCAGATGCCCAAAGATGTCATCATATCCCCCCACAACTGTGGCAAGCAGCCAGCCAA       ATTTGGGACGATCTGCTATGTAAGTTGCCGCCAAGGGTTCATTTTATCTGGAGTCAAAGAAATGCTGA       GATGTACCACTTCTGGAAAATGGAATGTCGGAGTTCAGGCAGCTGTGTGTAAAGACGTGGAGGCTCCT       CAAATCAACTGTCCTAAGGACATAGAGGCTAAGACTCTGGAACAGCAAGATTCTGCCAATGTTACCTG       GCAGATTCCAACAGCTAAAGACAACTCTGGTGAAAAGGTGTCAGTCCACGTTCATCCAGCTTTCACCC       CACCTTACCTTTTCCCAATTGGAGATGTTGCTATCGTATACACGGCAACTGACCTATCCGGCAACCAG       GCCAGCTGCATTTTCCATATCAAGGTTATTGATGCAGAACCACCTGTCATAGACTGGTGCAGATCTCC       ACCTCCCGTCCAGGTCTCGGAGAAGGTACATGCCGCAAGCTGGGATGAGCCTCAGTTCTCAGACAACT       CAGGTGCTGAATTGGTCATTACCAGAAGTCATACACAAGGAGACCTTTTCCCTCAAGGGGAGACTATA       GTACAGTATACAGCCACTGACCCCTCAGGCAATAACAGGACATGTGATATCCATATTGTCATAAAAGG       TTCTCCCTGTGAAATTCCATTCACACCTGTAAATGGGGATTTTATATGCACTCCAGATAATACTGGAG       TCAACTGTACATTAACTTGCTTGGAGGGCTATGATTTCACAGAAGGGTCTACTGACAAGTATTATTGT       GCTTATGAAGATGGCGTCTGGAAGCCAACATATACCACTGAATGGCCAGACTGTGCCAGTAAGCGTTT       TGCAAACCACGGGTTCAAGTCCTTTGAGATGTTCTACAAAGCAGCTCGTTGTGATGACACAGATCTGA       TGAAGAAGTTTTCTGAAGCATTTGAGACGACCCTGGGAAAAATGGTCCCATCATTTTGTAGTGATGCA       GAGGACATTGACTGCAGACTGGAGGAGAACCTGACCAAAAAATATTGCCTAGAATATAATTATGACTA       TGAAAATGGCTTTGCAATTGGTCCAGGTGGCTGGGGTGCAGCTCATAGGCTGGATTACTCTTACGATG       ACTTCCTGGACACTGTGCAAGAAACAGCCACAAGCATCGGCAATGCCAAGTCCTCACGGATTAAAAGA       AGTGCCCCATTATCTGACTATAAAATTAAGTTAATTTTTAACATCACAGCTAGTGTGCCATTACCCGA       TGAAAGAAATGATACCCTTGAATGGGAAAATCAGCAACGACTCCTTCAGACATTGGAAACTATCACAA       ATAAACTGAAAAGGACTCTCAACAAAGACCCCATGTATTCCTTTCAGCTTGCATCAGAAATACTTATA       GCCGACAGCAATTCATTAGAAACAAAAAAGGCTTCCCCCTTCTGCAGACCAGGCTCAGTGCTGAGAGG       GCGTATGTGTGTCAATTGCCCTTTGGGAACCTATTATAATCTGGAACATTTCACCTGTAGAAACTGCC       GGATCGGATCCTATCAAGATGAAGAAGGGCAACTTGAGTGCAAGCTTTGCCCCTCTGGGATGTACACG       GAATATATCCATTCAAGAAACATCTCTGATTGTAAAGCTCAGTGTAAACAAGGCACCTACTCATACAG       TGGACTTGAGACTTGTGAATCGTGTCCACTGGGCACTTATCAGCCAAAATTTGGTTCCCGGAGCTGCC       TCTCGTGTCCAGAAAACACCTCAACTGTGAAAAGAGGAGCCGTGAACATTTCTGCATGTGGAGTTCCT       GATCCATCACAGAATGTTCAAGTTTTAGTTCAACTTTCTCAGCGGCAGAGGAAAGTGTGGTGCCCCCT       CCCTTGCCACAATAGTGGAACCTGCCAGCAACTTGGGCGTGGTTATGTTTGTCTCTGTCCACTTGGAT       ATACAGGTTTAAAGTGTGAAACAGACATCGATGAGTGCAGCCCACTGCCTTGCCTCAACAATGGAGTT       TGTAAAGACCTAGTTGGGGAATTCATTTGTGAGTGCCCATCAGGTTACACAGGTAAGCACTGTGAATT       GAACATCAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTCAT       ACAGTTGTAAATGTCAGCCAGGATTTTCAGGCAAGGTGTGAAACAGGTATGTATCGTATCTCAGTGTT       ATTAATAACCTTAATAATGCAGTCTGTGAAGACCAGGTTGGGGGATTCTTGTGCAAATGCCCACCTGG       ATTTTTGGGTACCCGATGTGGAAAGAACGTCGATGAGTGTCTCAGTCAGCCATGCAAAAATGGAGCTA       CCTGTAAAGACGGTGCCAATAGCTTCAGGTGCCTGTGTGCAGCTGGCTTCACAGGATCACACTGTGAA       TTGAACATCAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTC       ATACAGTTGTAAATGTCAGCCAGGATTTTCAGGCAAAAGGTGTGAAACAGAACAGTCTACAGGCTTTA       ACCTGGATTTTGAAGTTTCTGGCATCTATGGATATGTCATGCTAGATGGCATGCTCCCATCTCTCCAT       GCTCTAACCTGTACCTTCTGGATGAAATCCTCTGACGACATGAACTATGGAACACCAATCTCCTATGC       AGTTGATAACGGCAGCGACAATACCTTGCTCCTGACTGATTATAACGGGTGGGTTCTTTATGTGAATG       GCAGGGAAAAGATAACAAACTGTCCCTCGGTGAATGATGGCAGATGGCATCATATTGCAATCACTTGG       ACAAGTACTGGTGGAGCCTGGAGGGTCTATATAAATGGGGAATTATCTGACGGTGGTACTGGCCTCTC       CATTGGCAAAGCCATACCTGGTGGCGGTGCATTAGTTCTTGGGCAAGAGCAAGACAAAAAAGGAGAGG       GGTTCAACCCGGCTGAGTCTTTTGTGGGCTCCATAAGCCAGCTCAACCTCTGGGACTATGTCCTGTCT       CCACAGCAGGTGAAGTCACTGGCTACCTCCTGCCCAGAGGAACTCAGTAAAGGAAACGTGTTAGCATG       GCCTGATTTCTTGTCAGGAATTGTGGGGAAAGTGAAGATCGATTCTAAGAGCATATTTTGTTCTGATT       GCCCACGCTTGGGAGGGTCAGTGCCTCATCTGAGAACTGCATCTGAAGATTTAAAACCAGGTTCCAAA       GTCAATCTGTTCTGTGAACCAGGCTTCCAGCTGGTCGGGAACCCTGTGCAGTACTGTCTGAATCAAGG       ACAGTGGACACAACCACTCCCCCACTGTGAACGCATTCGCTGTGGGGTGCCACCTCCTTTGGAGAATG       GCTTCCATTCAGCCGATGACTTCTATGCTGGCAGCACAGTAACCTACCAGTGCAACAATGGCTACTAT       CTATTGGGTGACTCAAGGATGTTCTGTACAGATAATGGGAGCTGGAACGGCGTTTCACCATCCTGCTT       AGATGTCGATGAGTGTGCAGTTGGATCAGATTGTAGTGAGCATGCTTCTTGCCTGAACGTAGATGGAT       CCTACATATGTTCATGTGTCCCACCGTACACAGGAGATGGGAAAAACTGTGCAGAACCTATAAAATGT       AAGGCTCCAGGAAATCCGGAAAATGGCCACTCCTCAGGTGAGATTTATACAGTAGGTGCCGAAGTCAC       ATTTTCGTGTCAGGAAGGATACCAGTTGATGGGAGTAACCAAAATCACATGTTTGGAGTCTGGAGAAT       GGAATCATCTAATACCATATTGTAAAGCTGTTTCATGTGGTAAACCGGCTATTCCAGAAAATGGTTGC       ATTGAGGAGTTAGCATTTACTTTTGGCAGCAAAGTGACATATAGGTGTAATAAAGGATATACTCTGGC       CGGTGATAAAGAATCATCCTGTCTTGCTAACAGTTCTTGGAGTCATTCCCCTCCTGTGTGTGAACCAG       TGAAGTGTTCTAGTCCGGAAAATATAAATAATGGAAAATATATTTTGAGTGGGCTTACCTACCTTTCT       ACTGCATCATATTCATGCGATACAGGATACAGCTTACAGGGCCCTTCCATTATTGAATGCACGGCTTC       TGGCATCTGGGACAGAGCGCCACCTGCCTGTCACCTCGTCTTCTGTGGAGAACCACCTGCCATCAAAG       ATGCTGTCATTACGGGGAATAACTTCACTTTCAGGAACACCGTCACTTACACTTGCAAAGAAGGCTAT       ACTCTTGCTGGTCTTGACACCATTGAATGCCTGGCCGACGGCAAGTGGAGTAGAAGTGACCAGCAGTG       CCTGGCTGTCTCCTGTGATGAGCCACCCATTGTGGACCACGCCTCTCCAGAGACTGCCCATCGGCTCT       TTGGAGACATTGCATTCTACTACTGCTCTGATGGTTACAGCCTAGCAGACAATTCCCAGCTTCTCTGC       AATGCCCAGGGCAAGTGGGTACCCCCAGAAGGTCAAGACATGCCCCGTTGTATAGCTCATTTCTGTGA       AAAACCTCCATCGGTTTCCTATAGCATCTTGGAATCTGTGAGCAAAGCAAAATTTGCAGCTGGCTCAG       TTGTGAGCTTTAAATGCATGGAAGGCTTTGTACTGAACACCTCAGCAAAGATTGAATGTATGAGAGGT       GGGCAGTGGAACCCTTCCCCCATGTCCATCCAGTGCATCCCTGTGCGGTGTGGAGAGCCACCAAGCAT       CATGAATGGCTATGCAAGTGGATCAAACTACAGTTTTGGAGCCATGGTGGCTTACAGCTGCAACAAGG       GGTTCTACATCAAAGGGGAAAAGAAGAGCACCTGCGAAGCCACAGGGCAGTGGAGTAGTCCTATACCG       ACGTGCCACCCGGTATCTTGTGGTGAACCACCTAAGGTTGAGAATGGCTTTCTGGAGCATACAACTGG       CAGGATCTTTGAGAGTGAAGTGAGGTATCAGTGTAACCCGGGCTATAAGTCAGTCGGAAGTCCTGTAT       TTGTCTGCCAAGCCAATCGCCACTGGCACAGTGAATCCCCTCTGATGTGTGTTCCTCTCGACTGTGGA       AAACCTCCCCCGATCCAGAATGGCTTCATGAAAGGAGAAAACTTTGAAGTAGGGTCCAAGGTTCAGTT       TTTCTGTAATGAGGGTTATGAGCTTGTTGGTGACAGTTCTTGGACATGTCAGAAATCTGGCAAATGGA       ATAAGAAGTCAAATCCAAAGTGCATGCCTGCCAAGTGCCCAGAGCCGCCCCTCTTGGAAAACCAGCTA       GTATTAAAGGAGTTGACCACCGAGGTAGGAGTTGTGACATTTTCCTGTAAAGAAGGGCATGTCCTGCA       AGGCCCCTCTGTCCTGAAATGCTTGCCATCCCAGCAATGGAATGACTCTTTCCCTGTTTGTAAGATTG       TTCTTTGTACCCCACCTCCCCTAATTTCCTTTGGTGTCCCCATTCCTTCTTCTGCTCTTCATTTTGGA       AGTACTGTCAAGTATTCTTGTGTAGGTGGGTTTTTCCTAAGAGGAAATTCTACCACCCTCTGCCAACC       TGATGGCACCTGGAGCTCTCCACTGCCAGAATGTGTTCCAGTAGAATGTCCCCAACCTGAGGAAATCC       CCAATGGAATCATTGATGTGCAAGGCCTTGCCTATCTCAGCACAGCTCTCTATACCTGCAAGCCAGGC       TTTGAATTGGTGGGAAATACTACCACCCTTTGTGGAGAAAATGGTCACTGGCTTGGAGGAAAACCAAC       ATGTAAAGCCATTGAGTGCCTGAAACCCAAGGAGATTTTGAATGGCAAATTCTCTTACACGGACCTAC       ACTATGGACAGACCGTTACCTACTCTTGCAACCGAGGCTTTCGGCTCGAAGGTCCCAGTGCCTTGACC       TGTTTAGAGACAGGTGATTGGGATGTAGATGCCCCATCTTGCAATGCCATCCACTGTGATTCCCCACA       ACCCATTGAAAATGGTTTTGTAGAAGGTGCAGATTACAGCTATGGTGCCATAATCATCTACAGTTGCT       TCCCTGGGTTTCAGGTGGCTGGTCATGCCATGCAGACCTGTGAAGAGTCAGGATGGTCAAGTTCCATC       CCAACATGTATGCCAATAGACTGTGGCCTCCCTCCTCATATAGATTTTGGAGACTGTACTAAACTCAA       AGATGACCAGGGATATTTTGAGCAAGAAGACGACATGATGGAAGTTCCATATGTGACTCCTCACCCTC       CTTATCATTTGGGAGCAGTGGCTAAAACCTGGGAAAATACAAAGGAGTCTCCTGCTACACATTCATCA       AACTTTCTGTATGGTACCATGGTTTCATACACCTGTAATCCAGGATATGAACTTCTGGGGAACCCTGT       GCTGATCTGCCAGGAAGATGGAACTTGGAATGGCAGTGCACCATCCTGCATTTCAATTGAATGTGACT       TGCCTACTGCTCCTGAAAATGGCTTTTTGCGTTTTACAGAGACTAGCATGGGAAGTGCTGTGCAGTAT       AGCTGTAAACCTGGACACATTCTAGCAGGCTCTGACTTAAGGCTTTGTCTAGAGAATAGAAAGTGGAG       TGGTGCCTCCCCACGCTGTGAAGCCATTTCATGCAAAAAGCCAAATCCAGTCATGAATGGATCCATCA       AAGGAAGCAACTACACATACCTGAGCACGTTGTACTATGAGTGTGACCCCGGATATGTGCTGAATGGC       ACTGAGAGGAGAACATGCCAGGATGACAAAAACTGGGATGAGGATGAGCCCATTTGCATTCCTGTGGA       CTGCAGTTCACCCCCAGTCTCAGCCAATGGCCAGGTGAGAGGAGACGAGTACACATTCCAAAAAGAGA       TTGAATACACTTGCAATGAAGGGTTCTTGCTTGAGGGAGCCAGGAGTCGGGTTTGTCTTGCCAATGGA       GGTGACGGAAGGCCTGGACTATGGCTTCATGAAGGAAGTAACATTCCACTGTCACGAGGGCTACATCT       TGCACGGTGCTCCAAAACTCACCTGTCAGTCAGATGGCAACTGGGATGCAGAGATTCCTCTCTGTAAA       CCAGTCAACTGTGGACCTCCTGAAGATCTTGCCCATGGTTTCCCTAATGGTTTTTCCTTTATTCATGG       GGGCCATATACAGTATCAGTGCTTTCCTGGTTATAAGCTCCATGGAAATTCATCAAGAAGGTGCCTCT       CCAATGGCTCCTGGAGTGGCAGCTCACCTTCCTGCCTGCCTTGCAGATGTTCCACACCAGTAATTGAA       TATGGAACTGTCAATGGGACAGATTTTGACTGTGGAAAGGCAGCCCGGATTCAGTGCTTCAAAGGCTT       CAAGCTCCTAGGACTTTCTGAAATCACCTGTGAAGCCGATGGCCAGTGGAGCTCTGGGTTCCCCCACT       AAGGAAAATGTGATAACTTACAGCTGCAGGTCTGGATATGTCATACAAGGCAGTTCAGATCTGATTTG       TACAGAGAAAGGGGTATGGAGCCAGCCTTATCCAGTCTGTGAGCCCTTGTCCTGTGGGTCCCCACCGT       CTGTCGCCAATGCAGTGGCAACTGGAGAGGCACACACCTATGAAAGTGAAGTGAAACTCAGATGTCTG       GAAGGTTATACGATGGATACAGATACAGATACATTCACCTGTCAGAAAGATGGTCGCTGGTTCCCTGA       GAGAATCTCCTGCAGTCCTAAAAAATGTCCTCTCCCGGAAAACATAACACATATACTTGTACATGGGG       ACGATTTCAGTGTGAATAGGCAAGTTTCTGTGTCATGTGCAGAAGGGTATACCTTTGAGGGAGTTAAC       ATATCAGTATGTCAGCTTGATGGAACCTGGGAGCCACCATTCTCCGATGAATCTTGCAGTCCAGTTTC       TTGTGGGAAACCTGAAAGTCCAGAACATGGATTTGTGGTTGGCAGTAAATACACCTTTGAAAGCACAA       TTATTTATCAGTGTGAGCCTGGCTATGAACTAGAGGGGAACAGGGAACGTGTCTGCCAGGAGAACAGA       CAGTGGAGTGGAGGGGTGGCAATATGCAAAGAGACCAGGTGTGAAACTCCACTTGAATTTCTCAATGG       GAAAGCTGACATTGAIAACAGGACGACTGGACCCAACGTGGTATATTCCTGCAACAGAGGCTACAGTC       TTGAAGGGCCATCTGAGGCACACTGCACAGAAAATGGAACCTGGAGCCACCCAGTCCCTCTCTGCAAA       CCAAATCCATGCCCTGTTCCTTTTGTGATTCCCGAGAATGCTCTGCTGTCTGAAAAGGAGTTTTATGT       TGATCAGAATGTGTCCATCAAATGTAGGGAAGGTTTTCTGCTGCAGGGCCACGGCATCATTACCTGCA       ACCCCGACGAGACGTGGACACAGACAAGCGCCAAATGTGAAAAAATCTCATGTGGTCCACCAGCTCAC       GTAGAAAATGCAATTGCTCGAGGCGTACATTATCAATATGGAGACATGATCACCTACTCATGTTACAG       TGGATACATGTTGGAGGGTTTCCTGAGGAGTGTTTGTTTAGAAAATGGAACATGGACATCACCTCCTA       TTTGCAGAGCTGTCTGTCGATTTCCATGTCAGAATGGGGGCATCTGCCAACGCCCAAATGCTTGTTCC       TGTCCAGAGGGCTGGATGGGGCGCCTCTGTGAAGAACCAATCTGCATTCTTCCCTGTCTGAACGGAGG       TCGCTGTGTGGCCCCTTACCAGTGTGACTGCCCGCCTGGCTGGACGGGGTCTCGCTGTCATACAGCTG       TTTGCCAGTCTCCCTGCTTAAATGGTGGAAAATGTGTAAGACCAAACCGATGTCACTGTCTTTCTTCT       TGGACGGGACATAACTGTTCAAGGAAAAGGAGGACTGGGTTTTAACCACTGCACGACCATCTGGCTCT       CCCAAAAGCAGGATCATCTCTCCTCGGTAGTGCCTGGGCATCCTGGAACTTATGCAAAGAAAGTCCAA       CATGGTGCTGGGTCTTGTTTAGTAAACTTGTTACTTGGGGTTACTTTTTTTATTTTGTGATATATTTT       GTTATTCCTTGTGACATACTTTCTTACATGTTTCCATTTTTAAATATGCCTGTATTTTCTATATAAAA       ATTATATTAAATAGATGCTGCTCTACCCTCACAAAATGTACATATTCTGCTGTCTATTGGGAAAGTTC       CTGGTACACATTTTTATTCAGTTACTTAAAATGATTTTTCCATTAAAGTATATTTTGCTACTAAATAA       AAAAAA                                                 NOV8k, SNP13380899 of   SEQ ID NO: 198       MW at 390012.5kD                                 CG50646-04, Protein Sequence   SNP Pos: 776   3570 aa   SNP Change: Lys to Lys                             MRRICAACWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRVERLGQAFR           VRLLRELSERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRVDY       ISTRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPI       AASLRDSGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEAIVALCHMLFVDLPSGSFIQDD       MVHCSYLCDEGKDCCDRMGSCKCGKHTGHFECICEKGYNGKGLQYDCTVCPSGTYKPEGSPGGISSCI       PCPDENHTSPPGSTSPEDCVCREGYRASGQTCEVVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPG       FDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK       LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCT       TSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEKVSVHVHPAFTPPY       LFPIGDVAIVYTATDLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWDEPQFSDNSGA       ELVITRSHTQGDLFPQGETIVQYTATDPSGNNRTCDIHIVIKGSPCEIPFTPVNGDFICTPDNTGVNC       TLTCLEGYDFTEGSTDKYYCAYEDGVWKPTYTTEWPDCASKRFANHGFKSFEMFYKAARCDDTDLMKK       FSEAFETTLGKMVPSFCSDAEDIDCRLEENLTKYYCLEYNYDYENGFAIGPGGWGAANRLDYSYDDFL       DTVQETATSIGNAKSSRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKL       KRTLNKDPMYSFQLASEILIADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRIG       SYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSC       PENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSI       TECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQASHECFFNPCHNSGTCQQLGRGYVCLCPLGYTG       LKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGKHCELNINECQSNPCRNQATCVDELNSYSC       KCQPGFSGKRCETGMYQLSVINNLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCK       DGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLD       FEVSGIYGYVMLDGMLPSLHALTCTFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGRE       KITNCPSVNDGRWHHIAITWTSTGGAWRVYINGELSDGGTGLSIGKAIPGGGALVLGQEQDKKGEGFN       PAESFVGSISQLNLWDYLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPR       LGGSVPHLRTASEDLKPGSKVNLFCEPGFQLVGNPVQYCLNQGQWTQPLPHCERIRCGVPPPLENGFH       SADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYI       CSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNH       LIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKC       SSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAV       ITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGD       IAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVS       FKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFY       IKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVC       QANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKK       SNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLC       TPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNG       IIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYG       QTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPG       FQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMNEVPYVTPHPPYH       LGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPT       APENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGS       NYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEY       TCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHG       APKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNG       SWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEH       TSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVA       NAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDF       SVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIY       QCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEG       PSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPD       ETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICR       AVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQ       SPCLNGGKCVRPNRCHCLSSWTGHNCSRKRRTGF                                                 SEQ ID NO: 199   11158 bp                                 NOV8l, SNP13374702 of   ORF Start: ATG at 77   ORF Stop: TAA at 10787                             CG50646-04, DNA Sequence   SNP Pos: 2457   SNP Change: A to G                             CAATTGGTCTAGGGTCTCCCCCATTGGAATATCCATCAGTGATGAGAAATACAACGTTTGTTGAGTTT           TCTCTAGCATGAGAAGAATTTGCGCGGCTTGCTGGGGTCTGGCGCTCGTTTCGGGCTGGGCGACCTTT       CAGCAGATGTCCCCGTCGCGCAATTTCAGCTTCCGCCTCTTCCCCGAGACCGCGCCCGGGGCCCCCGG       GAGTATCCCCGCGCCGCCCGCTCCTGGCGACGAAGCGGCGGGGAGCAGAGTGGAGCGGCTGGGCCAGG       CGTTCCGCGTGCGGCTGCTGCGGGAGCTCAGCGAGCGCCTGGAGCTTGTCTTCCTGGTGGATGATTCG       TCCAGCGTGGGCGAAGTCAACTTCCGCAGCGAGCTCATGTTCGTCCGCAAGCTGCTGTCCGACTTCCC       CGTGGTGCCCACGGCCACGCGCGTGGCCATCGTGACCTTCTCGTCCAAGAACTACGTGGTGCCGCGCG       TCGATTACATCTCCACCCGCCGCGCGCGCCAGCACAAGTGCGCGCTGCTCCTCCAAGAGATCCCTGCC       ATCTCCTACCGAGGTGGCGGCACCTACACCAAGGGCGCCTTCCAGCAAGCCGCGCAAATTCTTCTTCA       TGCTAGAGAAAACTCAACAAAAGTTGTATTTCTCATCACTGATGGATATTCCAATGGGGGAGACCCTA       GACCAATTGCAGCGTCACTGCGAGATTCAGGAGTGGAGATCTTCACTTTTGGCATATGGCAAGGGAAC       ATTCGAGAGCTGAATGACATGGCTTCCACCCCAAAGGAGGAGCACTGTTACCTGCTACACAGTTTTGA       AGAATTTGAGGCTTTAGTCGCCCTCTGTCATATGTTATTTGTAGATCTACCTTCTGGGAGTTTTATTC       AAGATGATATGGTCCACTGCTCATATCTTTGTGATGAAGGCAAGGACTGCTGTGACCGAATGGGAAGC       TGCAAATGTGGGAAACACACAGGCCATTTTGAGTGCATCTGTGAAAAGGGGTATAACGGGAAAGGTCT       GCAGTATGACTGCACAGTTTGCCCATCGGGGACATACAAACCTGAAGGCTCACCAGGAGGAATCAGCA       GTTGCATTCCATGTCCTGATGAAAATCACACCTCTCCACCTGGAAGCACATCCCCTGAAGACTGTGTC       TGCAGAGAGGGATACAGGGCATCTGGCCAGACCTGTGAAGTTGTCCACTGCCCTGCCCTGAAGCCTCC       CGAAAATGGTTACTTTATCCAAAACACTTGCAACAACCACTTCAATGCAGCCTGTGGGGTCCGATGTC       ACCCTGGATTTGATCTTGTGGGAAGCAGCATCATCTTATGTCTACCCAATGGTTTGTGGTCCGGTTCA       GAGAGCTACTGCAGAGTAAGAACATGTCCTCATCTCCGCCAGCCGAAACATGGCCACATCAGCTGTTC       TACAAGGGAAATGTTATATAAGACAACATGTTTGGTTGCCTGTGATGAAGGGTACAGGCTAGAAGGCA       GTGATAAGCTTACTTGTCAAGGAAACAGCCAGTGGGATGGGCCAGAACCCCGGTGTGTGGAGCGCCAC       TGTTCCACCTTTCAGATGCCCAAAGATGTCATCATATCCCCCCACAACTGTGGCAAGCAGCCAGCCAA       ATTTGGGACGATCTGCTATGTAAGTTGCCGCCAAGGGTTCATTTTATCTGGAGTCAAAGAAATGCTGA       GATGTACCACTTCTGGAAAATGGAATGTCGGAGTTCAGGCAGCTGTGTGTAAAGACGTGGAGGCTCCT       CAAATCAACTGTCCTAAGGACATAGAGGCTAAGACTCTGGAACAGCAAGATTCTGCCAATGTTACCTG       GCAGATTCCAACAGCTAAAGACAACTCTGGTGAAAAGGTGTCAGTCCACGTTCATCCAGCTTTCACCC       CACCTTACCTTTTCCCAATTGGAGATGTTGCTATCGTATACACGGCAACTGACCTATCCGGCAACCAG       GCCAGCTGCATTTTCCATATCAAGGTTATTGATGCAGAACCACCTGTCATAGACTGGTGCAGATCTCC       ACCTCCCGTCCAGGTCTCGGAGAAGGTACATGCCGCAAGCTGGGATGAGCCTCAGTTCTCAGACAACT       CAGGTGCTGAATTGGTCATTACCAGAAGTCATACACAAGGAGACCTTTTCCCTCAAGGGGAGACTATA       GTACAGTATACAGCCACTGACCCCTCAGGCAATAACAGGACATGTGATATCCATATTGTCATAAAAGG       TTCTCCCTGTGAAATTCCATTCACACCTGTAAATGGGGATTTTATATGCACTCCAGATAATACTGGAG       TCAACTGTACATTAACTTGCTTGGAGGGCTATGATTTCACAGAAGGGTCTACTGACAAGTATTATTGT       GCTTATGAAGATGGCGTCTGGAAACCAACATATACCACTGAATGGCCAGACTGTGCCAGTAAGCGTTT       TGCAAACCGCGGGTTCAAGTCCTTTGAGATGTTCTACAAAGCAGCTCGTTGTGATGACACAGATCTGA       TGAAGAAGTTTTCTGAAGCATTTGAGACGACCCTGGGAAAAATGGTCCCATCATTTTGTAGTGATGCA       GAGGACATTGACTGCAGACTGGAGGAGAACCTGACCAAAAAATATTGCCTAGAATATAATTATGACTA       TGAAAATGGCTTTGCAATTGGTCCAGGTGGCTGGGGTGCAGCTAATAGGCTGGATTACTCTTACGATG       ACTTCCTGGACACTGTGCAAGAAACAGCCACAAGCATCGGCAATGCCAAGTCCTCACGGATTAAAAGA       AGTGCCCCATTATCTGACTATAAAATTAAGTTAATTTTTAACATCACAGCTAGTGTGCCATTACCCGA       ATAAACTGAAAAGGACTCTCAACAAAGACCCCATGTATTCCTTTCAGCTTGCATCAGAAATACTTATA       GCCGACAGCAATTCATTAGAAACAAAAAAGGCTTCCCCCTTCTGCAGACCAGGCTCAGTGCTGAGAGG       GCGTATGTGTGTCAATTGCCCTTTGGGAACCTATTATAATCTGGAACATTTCACCTGTGAAAGCTGCC       GGATCGGATCCTATCAAGATGAAGAAGGGCAACTTGAGTGCAAGCTTTGCCCCTCTGGGATGTACACG       GAATATATCCATTCAAGAAACATCTCTGATTGTAAAGCTCAGTGTAAACAAGGCACCTACTCATACAG       TGGACTTGAGACTTGTGAATCGTGTCCACTGGGCACTTATCAGCCAAAATTTGGTTCCCGGAGCTGCC       TCTCGTGTCCAGAAAACACCTCAACTGTGAAAAGAGGAGCCGTGAACATTTCTGCATGTGGAGTTCCT       TGTCCAGAAGGAAAATTCTCGCGTTCTGGGTTAATGCCCTGTCACCCATGTCCTCGTGACTATTACCA       ACCTAATGCAGGGAAGGCCTTCTGCCTGGCCTGTCCCTTTTATGGAACTACCCCATTCGCTGGTTCCA       GATCCATCACAGAATGTTCAAGTTTTAGTTCAACTTTCTCAGCGGCAGAGGAAAGTGTGGTGCCCCCT       GCCTCTCTTGGACATATTAAAAAGAGGCATGAAATCAGCAGTCAGGCAAGTCATGAATGCTTCTTTAA       CCCTTGCCACAATAGTGGAACCTGCCAGCAACTTGGGCGTGGTTATGTTTGTCTCTGTCCACTTGGAT       ATACAGGTTTAAAGTGTGAAACAGACATCGATGAGTGCAGCCCACTGCCTTGCCTCAACAATGGAGTT       TGTAAAGACCTAGTTGGGGAATTCATTTGTGAGTGCCCATCAGGTTACACAGGTAAGCACTGTGAATT       GAACATCAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTCAT       ACAGTTGTAAATGTCAGCCAGGATTTTCAGGCAAAAGGTGTGAAACAGGTATGTATCAACTCAGTGTT       ATTAATAACCTTAATAATGCAGTCTGTGAAGACCAGGTTGGGGGATTCTTGTGCAAATGCCCACCTGG       ATTTTTGGGTACCCGATGTGGAAAGAACGTCGATGAGTGTCTCAGTCAGCCATGCAAAAATGGAGCTA       CCTGTAAAGACGGTGCCAATAGCTTCAGGTGCCTGTGTGCAGCTGGCTTCACAGGATCACACTGTGAA       TTGAACATCAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTC       ATACAGTTGTAAATGTCAGCCAGGATTTTCAGGCAAAAGGTGTGAAACAGAACAGTCTACAGGCTTTA       ACCTGGATTTTGAAGTTTCTGGCATCTATGGATATGTCATGCTAGATGGCATGCTCCCATCTCTCCAT       GCTCTAACCTGTACCTTCTGGATGAAATCCTCTGACGACATGAACTATGGAACACCAATCTCCTATGC       AGTTGATAACGGCAGCGACAATACCTTGCTCCTGACTGATTATAACGGGTGGGTTCTTTATGTGAATG       GCAGGGAAAAGATAACAAACTGTCCCTCGGTGAATGATGGCAGATGGCATCATATTGCAATCACTTGG       ACAAGTACTGGTGGAGCCTGGAGGGTCTATATAAATGGGGAATTATCTGACGGTGGTACTGGCCTCTC       CATTGGCAAAGCCATACCTGGTGGCGGTGCATTAGTTCTTGGGCAAGAGCAAGACAAAAAAGGAGAGG       GGTTCAACCCGGCTGAGTCTTTTGTGGGCTCCATAAGCCAGCTCAACCTCTGGGACTATGTCCTGTCT       CCACAGCAGGTGAAGTCACTGGCTACCTCCTGCCCAGAGGAACTCAGTAAAGGAAACGTGTTAGCATG       GCCTGATTTCTTGTCAGGAATTGTGGGGAAAGTGAAGATCGATTCTAAGAGCATATTTTGTTCTGATT       GCCCACGCTTGGGAGGGTCAGTGCCTCATCTGAGAACTGCATCTGAAGATTTAAAACCAGGTTCCAAA       GTCAATCTGTTCTGTGAACCAGGCTTCCAGCTGGTCGGGAACCCTGTGCAGTACTGTCTGAATCAAGG       ACAGTGGACACAACCACTCCCCCACTGTGAACGCATTCGCTGTGGGGTGCCACCTCCTTTGGAGAATG       GCTTCCATTCAGCCGATGACTTCTATGCTGGCAGCACAGTAACCTACCAGTGCAACAATGGCTACTAT       CTATTGGGTGACTCAAGGATGTTCTGTACAGATAATGGGAGCTGGAACGGCGTTTCACCATCCTGCTT       AGATGTCGATGAGTGTGCAGTTGGATCAGATTGTAGTGAGCATGCTTCTTGCCTGAACGTAGATGGAT       CCTACATATGTTCATGTGTCCCACCGTACACAGGAGATGGGAAAAACTGTGCAGAACCTATAAAATGT       AAGGCTCCAGGAAATCCGGAAAATGGCCACTCCTCAGGTGAGATTTATACAGTAGGTGCCGAAGTCAC       ATTTTCGTGTCAGGAAGGATACCAGTTGATGGGAGTAACCAAAATCACATGTTTGGAGTCTGGAGAAT       GGAATCATCTAATACCATATTGTAAAGCTGTTTCATGTGGTAAACCGGCTATTCCAGAAAATGGTTGC       ATTGAGGAGTTAGCATTTACTTTTGGCAGCAAAGTGACATATAGGTGTAATAAAGGATATACTCTGGC       CGGTGATAAAGAATCATCCTGTCTTGCTAACAGTTCTTGGAGTCATTCCCCTCCTGTGTGTGAACCAG       TGAAGTGTTCTAGTCCGGAAAATATAAATAATGGAAAATATATTTTGAGTGGGCTTACCTACCTTTCT       ACTGCATCATATTCATGCGATACAGGATACAGCTTACAGGGCCCTTCCATTATTGAATGCACGGCTTC       TGGCATCTGGGACAGAGCGCCACCTGCCTGTCACCTCGTCTTCTGTGGAGAACCACCTGCCATCAAAG       ATGCTGTCATTACGGGGAATAACTTCACTTTCAGGAACACCGTCACTTACACTTGCAAAGAAGGCTAT       ACTCTTGCTGGTCTTGACACCATTGAATGCCTGGCCGACGGCAAGTGGAGTAGAAGTGACCAGCAGTG       CCTGGCTGTCTCCTGTGATGAGCCACCCATTGTGGACCACGCCTCTCCAGAGACTGCCCATCGGCTCT       TTGGAGACATTGCATTCTACTACTGCTCTGATGGTTACAGCCTAGCAGAGACTTCCCAGCTTCTCTGC       AATGCCCAGGGCAAGTGGGTACCCCCAGAAGGTCAAGACATGCCCCGTTGTATAGCTCATTTCTGTGA       AAAACCTCCATCGGTTTCCTATAGCATCTTGGAATCTGTGAGCAAAGCAAAATTTGCAGCTGGCTCAG       TTGTGAGCTTTAAATGCATGGAAGGCTTTGTACTGAACACCTCAGCAAAGATTGAATGTATGAGAGGT       CATGAATGGCTATGCAAGTGGATCAAACTACAGTTTTGGAGCCATGGTGGCTTACAGCTGCAACAAGG       GGTTCTACATCAAAGGGGAAAAGAAGAGCACCTGCGAAGCCACAGGGCAGTGGAGTAGTCCTATACCG       ACGTGCCACCCGGTATCTTGTGGTGAACCACCTAAGGTTGAGAATGGCTTTCTGGAGCATACAACTGG       CAGGATCTTTGAGAGTGAAGTGAGGTATCAGTGTAACCCGGGCTATAAGTCAGTCGGAAGTCCTGTAT       TTGTCTGCCAAGCCAATCGCCACTGGCACAGTGAATCCCCTCTGATGTGTGTTCCTCTCGACTGTGGA       AAACCTCCCCCGATCCAGAATGGCTTCATGAAAGGAGAAAACTTTGAAGTAGGGTCCAAGGTTCAGTT       TTTCTGTAATGAGGGTTATGAGCTTGTTGGTGACAGTTCTTGGACATGTCAGAAATCTGGCAAATGGA       ATAAGAAGTCAAATCCAAAGTGCATGCCTGCCAAGTGCCCAGAGCCGCCCCTCTTGGAAAACCAGCTA       GTATTAAAGGAGTTGACCACCGAGGTAGGAGTTGTGACATTTTCCTGTAAAGAAGGGCATGTCCTGCA       AGGCCCCTCTGTCCTGAAATGCTTGCCATCCCAGCAATGGAATGACTCTTTCCCTGTTTGTAAGATTG       TTCTTTGTACCCCACCTCCCCTAATTTCCTTTGGTGTCCCCATTCCTTCTTCTGCTCTTCATTTTGGA       AGTACTGTCAAGTATTCTTGTGTAGGTGGGTTTTTCCTAAGAGGAAATTCTACCACCCTCTGCCAACC       TGATGGCACCTGGAGCTCTCCACTGCCAGAATGTGTTCCAGTAGAATGTCCCCAACCTGAGGAAATCC       CCAATGGAATCATTGATGTGCAAGGCCTTGCCTATCTCAGCACAGCTCTCTATACCTGCAAGCCAGGC       TTTGAATTGGTGGGAAATACTACCACCCTTTGTGGAGAAAATGGTCACTGGCTTGGAGGAAAACCAAC       ATGTAAAGCCATTGAGTGCCTGAAACCCAAGGAGATTTTGAATGGCAAATTCTCTTACACGGACCTAC       ACTATGGACAGACCGTTACCTACTCTTGCAACCGAGGCTTTCGGCTCGAAGGTCCCAGTGCCTTGACC       TGTTTAGAGACAGGTGATTGGGATGTAGATGCCCCATCTTGCAATGCCATCCACTGTGATTCCCCACA       ACCCATTGAAAATGGTTTTGTAGAAGGTGCAGATTACAGCTATGGTGCCATAATCATCTACAGTTGCT       TCCCTGGGTTTCAGGTGGCTGGTCATGCCATGCAGACCTGTGAAGAGTCAGGATGGTCAAGTTCCATC       CCAACATGTATGCCAATAGACTGTGGCCTCCCTCCTCATATAGATTTTGGAGACTGTACTAAACTCAA       AGATGACCAGGGATATTTTGAGCAAGAAGACGACATGATGGAAGTTCCATATGTGACTCCTCACCCTC       CTTATCATTTGGGAGCAGTGGCTAAAACCTGGGAAAATACAAAGGAGTCTCCTGCTACACATTCATCA       AACTTTCTGTATGGTACCATGGTTTCATACACCTGTAATCCAGGATATGAACTTCTGGGGAACCCTGT       GCTGATCTGCCAGGAAGATGGAACTTGGAATGGCAGTGCACCATCCTGCATTTCAATTGAATGTGACT       TGCCTACTGCTCCTGAAAATGGCTTTTTGCGTTTTACAGAGACTAGCATGGGAAGTGCTGTGCAGTAT       AGCTGTAAACCTGGACACATTCTAGCAGGCTCTGACTTAAGGCTTTGTCTAGAGAATAGAAAGTGGAG       TGGTGCCTCCCCACGCTGTGAAGCCATTTCATGCAAAAAGCCAAATCCAGTCATGAATGGATCCATCA       AAGGAAGCAACTACACATACCTGAGCACGTTGTACTATGAGTGTGACCCCGGATATGTGCTGAATGGC       ACTGAGAGGAGAACATGCCAGGATGACAAAAACTGGGATGAGGATGAGCCCATTTGCATTCCTGTGGA       CTGCAGTTCACCCCCAGTCTCAGCCAATGGCCAGGTGAGAGGAGACGAGTACACATTCCAAAAAGAGA       TTGAATACACTTGCAATGAAGGGTTCTTGCTTGAGGGAGCCAGGAGTCGGGTTTGTCTTGCCAATGGA       AGTTGGAGTGGAGCCACTCCCGACTGTGTGCCTGTCAGATGTGCCACCCCGCCACAACTGGCCAATGG       GGTGACGGAAGGCCTGGACTATGGCTTCATGAAGGAAGTAACATTCCACTGTCACGAGGGCTACATCT       TGCACGGTGCTCCAAAACTCACCTGTCAGTCAGATGGCAACTGGGATGCAGAGATTCCTCTCTGTAAA       CCAGTCAACTGTGGACCTCCTGAAGATCTTGCCCATGGTTTCCCTAATGGTTTTTCCTTTATTCATGG       GGGCCATATACAGTATCAGTGCTTTCCTGGTTATAAGCTCCATGGAAATTCATCAAGAAGGTGCCTCT       CCAATGGCTCCTGGAGTGGCAGCTCACCTTCCTGCCTGCCTTGCAGATGTTCCACACCAGTAATTGAA       TATGGAACTGTCAATGGGACAGATTTTGACTGTGGAAAGGCAGCCCGGATTCAGTGCTTCAAAGGCTT       CAAGCTCCTAGGACTTTCTGAAATCACCTGTGAAGCCGATGGCCAGTGGAGCTCTGGGTTCCCCCACT       GTGAACACACTTCTTGTGGTTCTCTTCCAATGATACCAAATGCGTTCATCAGTGAGACCAGCTCTTGG       AAGGAAAATGTGATAACTTACAGCTGCAGGTCTGGATATGTCATACAAGGCAGTTCAGATCTGATTTG       TACAGAGAAAGGGGTATGGAGCCAGCCTTATCCAGTCTGTGAGCCCTTGTCCTGTGGGTCCCCACCGT       CTGTCGCCAATGCAGTGGCAACTGGAGAGGCACACACCTATGAAAGTGAAGTGAAACTCAGATGTCTG       GAAGGTTATACGATGGATACAGATACAGATACATTCACCTGTCAGAAAGATGGTCGCTGGTTCCCTGA       GAGAATCTCCTGCAGTCCTAAAAAATGTCCTCTCCCGGAAAACATAACACATATACTTGTACATGGGG       ACGATTTCAGTGTGAATAGGCAAGTTTCTGTGTCATGTGCAGAAGGGTATACCTTTGAGGGAGTTAAC       ATATCAGTATGTCAGCTTGATGGAACCTGGGAGCCACCATTCTCCGATGAATCTTGCAGTCCAGTTTC       TTGTGGGAAACCTGAAAGTCCAGAACATGGATTTGTGGTTGGCAGTAAATACACCTTTGAAAGCACAA       TTATTTATCAGTGTGAGCCTGGCTATGAACTAGAGGGGAACAGGGAACGTGTCTGCCAGGAGAACAGA       CAGTGGAGTGGAGGGGTGGCAATATGCAAAGAGACCAGGTGTGAAACTCCACTTGAATTTCTCAATGG       GAAAGCTGACATTGAAAACAGGACGACTGGACCCAACGTGGTATATTCCTGCAACAGAGGCTACAGTC       TTGAAGGGCCATCTGAGGCACACTGCACAGAAAATGGAACCTGGAGCCACCCAGTCCCTCTCTGCAAA       CCAAATCCATGCCCTGTTCCTTTTGTGATTCCCGAGAATGCTCTGCTGTCTGAAAAGGAGTTTTATGT       TGATCAGAATGTGTCCATCAAATGTAGGGAAGGTTTTCTGCTGCAGGGCCACGGCATCATTACCTGCA       ACCCCGACGAGACGTGGACACAGACAAGCGCCAAATGTGAAAAAATCTCATGTGGTCCACCAGCTCAC       GTAGAAAATGCAATTGCTCGAGGCGTACATTATCAATATGGAGACATGATCACCTACTCATGTTACAG       TGGATACATGTTGGAGGGTTTCCTGAGGAGTGTTTGTTTAGAAAATGGACAATGGACATCACCTCCTA       TTTGCAGAGCTGTCTGTCGATTTCCATGTCAGAATGGGGGCATCTGCCAACGCCCAAATGCTTGTTCC       TGTCCAGAGGGCTGGATGGGGCGCCTCTGTGAAGAACCAATCTGCATTCTTCCCTGTCTGAACGGAGG       TCGCTGTGTGGCCCCTTACCAGTGTGACTGCCCGCCTGGCTGGACGGGGTCTCGCTGTCATACAGCTG       TTTGCCAGTCTCCCTGCTTAAATGGTGGALAATGTGTAAGACCAAACCGATGTCACTGTCTTTCTTCT       TGGACGGGACATAACTGTTCCAGGAAAAGGAGGACTGGGTTTTAACCACTGCACGACCATCTGGCTCT       CCCAAAAGCAGGATCATCTCTCCTCGGTAGTGCCTGGGCATCCTGGAACTTATGCAAAGAAAGTCCAA       CATGGTGCTGGGTCTTGTTTAGTAAACTTGTTACTTGGGGTTACTTTTTTTATTTTGTGATATATTTT       GTTATTCCTTGTGACATACTTTCTTACATGTTTCCATTTTTAAATATGCCTGTATTTTCTATATAAAA       ATTATATTAAATAGATGCTGCTCTACCCTCACAAAATGTACATATTCTGCTGTCTATTGGGAAAGTTC       CTGGTACACATTTTTATTCAGTTACTTAAAATGATTTTTCCATTAAAGTATATTTTGCTACTAAATAA       AAAAAA                                                 NOV8l, SNP13374702 of   SEQ ID NO: 200       MW at 390031.5kD                                 CG50646-04, Protein Sequence   SNP Pos: 794   3570 aa   SNP Change: His to Arg                             MRRICAACWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRVERLGQAFR           VRLLRELSERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRVDY       ISTRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPI       AASLRDSGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALVALCHMLFVDLPSGSFIQDD       MVHCSYLCDEGKDCCDRMGSCKCGKHTGHFECICEKGYNGKGLQYDCTVCPSGTYKPEGSPGGISSCI       PCPDENHTSPPGSTSPEDCVCREGYPASGQTCEVVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPG       FDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK       LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCT       TSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEKVSVHVHPAFTPPY       LFPIGDVAIVYTATDLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWDEPQFSDNSGA       ELVITRSHTQGDLFPQGETIVQYTATDPSGNNRTCDIHIVIKGSPCEIPFTPVNGDFICTPDNTGVNC       TLTCLEGYDFTEGSTDKYYCAYEDGVWKPTYTTEWPDCASKRFANRGFKSFEMFYKAARCDDTDLMKK       FSEAFETTLGKMVPSFCSDAEDIDCPLEENLTKKYCLEYNYDYENGFAIGPGGWGAANRLDYSYDDFL       DTVQETATSIGNAKSSRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKL       KRTLNKDPMYSFQLASEILIADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRIG       SYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSC       TECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQASHECFFNPCHNSGTCQQLGRGYVCLCPLGYTG       LKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGKHCELNINECQSNPCRNQATCVDELNSYSC       KCQPGFSGKRCETGMYQLSVINNLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCK       DGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLD       FEVSGIYGYVMLDGMLPSLHALTCTFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGRE       KITNCPSVNDGRWHHIAITWTSTGGAWRVYINGELSDGGTGLSIGKAIPGGGALVLGQEQDKKGEGFN       PAESFVGSISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPR       LGGSVPHLRTASEDLKPGSKVNLFCEPGFQLVGNPVQYCLNQGQWTQPLPHCERIRCGVPPPLENGFH       SADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYI       CSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNH       LIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKC       SSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAV       ITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGD       IAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVS       FKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFY       IKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVC       QANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKK       SNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLC       TPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNG       IIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYG       QTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPG       FQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDNMEVPYVTPHPPYH       LGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPT       APENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGS       NYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEY       TCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHG       APKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNG       SWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEH       TSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVA       NAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDF       SVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKFESPEHGFVVGSKYTFESTIIY       QCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEG       PSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPD       ETWTQTSAKCEKISCGPPAHVENAIARGVHYGYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICR       AVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQ       SPCLNGGKCVRPNRCHCLSSWTGHNCSRKRRTGF                                                 SEQ ID NO: 201   11158 bp                                 NOV8m, SNP13374257 of   ORF Start: ATG at 77   ORF Stop: TAA at 10787                             CG50646-04, DNA Sequence   SNP Pos: 7217   SNP Change: A to G                             CAATTGGTCTAGGGTCTCCCCCATTGGAATATCCATCAGTGATGAGAAATACAACGTTTGTTGAGTTT           TCTCTAGCATGAGAAGAATTTGCGCGGCTTGCTGGGGTCTGGCGCTCGTTTCGGGCTGGGCGACCTTT       CAGCAGATGTCCCCGTCGCGCAATTTCAGCTTCCGCCTCTTCCCCGAGACCGCGCCCGGGGCCCCCGG       GAGTATCCCCGCGCCGCCCGCTCCTGGCGACGAAGCGGCGGGGAGCAGAGTGGAGCGGCTGGGCCAGG       CGTTCCGCGTGCGGCTGCTGCGGGAGCTCAGCGAGCGCCTGGAGCTTGTCTTCCTGGTGGATGATTCG       TCCAGCGTGGGCGAAGTCAACTTCCGCAGCGAGCTCATGTTCGTCCGCAAGCTGCTGTCCGACTTCCC       CGTGGTGCCCACGGCCACGCGCGTGGCCATCGTGACCTTCTCGTCCAAGAACTACGTGGTGCCGCGCG       TCGATTACATCTCCACCCGCCGCGCGCGCCAGCACAAGTGCGCGCTGCTCCTCCAAGAGATCCCTGCC       ATCTCCTACCGAGGTGGCGGCACCTACACCAAGGGCGCCTTCCAGCAAGCCGCGCAAATTCTTCTTCA       TGCTAGAGAAAACTCAACAAAAGTTGTATTTCTCATCACTGATGGATATTCCAATGGGGGAGACCCTA       GACCAATTGCAGCGTCACTGCGAGATTCAGGAGTGGAGATCTTCACTTTTGGCATATGGCAAGGGAAC       ATTCGAGAGCTGAATGACATGGCTTCCACCCCAAAGGAGGAGCACTGTTACCTGCTACACAGTTTTGA       AGAATTTGAGGCTTTAGTCGCCCTCTGTCATATGTTATTTGTAGATCTACCTTCTGGGAGTTTTATTC       AAGATGATATGGTCCACTGCTCATATCTTTGTGATGAAGGCAAGGACTGCTGTGACCGAATGGGAAGC       TGCAAATGTGGGAAACACACAGGCCATTTTGAGTGCATCTGTGAAAAGGGGTATAACGGGAAAGGTCT       GCAGTATGACTGCACAGTTTGCCCATCGGGGACATACAAACCTGAAGGCTCACCAGGAGGAATCAGCA       GTTGCATTCCATGTCCTGATGAAAATCACACCTCTCCACCTGGAAGCACATCCCCTGAAGACTGTGTC       TGCAGAGAGGGATACAGGGCATCTGGCCAGACCTGTGAAGTTGTCCACTGCCCTGCCCTGAAGCCTCC       CGAAAATGGTTACTTTATCCAAAACACTTGCAACAACCACTTCAATGCAGCCTGTGGGGTCCGATGTC       ACCCTGGATTTGATCTTGTGGGAAGCAGCATCATCTTATGTCTACCCAATGGTTTGTGGTCCGGTTCA       GAGAGCTACTGCAGAGTAAGAACATGTCCTCATCTCCGCCAGCCGAAACATGGCCACATCAGCTGTTC       TACAAGGGAAATGTTATATAAGACAACATGTTTGGTTGCCTGTGATGAAGGGTACAGGCTAGAAGGCA       GTGATAAGCTTACTTGTCAAGGAAACAGCCAGTGGGATGGGCCAGAACCCCGGTGTGTGGAGCGCCAC       TGTTCCACCTTTCAGATGCCCAAAGATGTCATCATATCCCCCCACAACTGTGGCAAGCAGCCAGCCAA       ATTTGGGACGATCTGCTATGTAAGTTGCCGCCAAGGGTTCATTTTATCTGGAGTCAAAGAAATGCTGA       GATGTACCACTTCTGGAAAATGGAATGTCGGAGTTCAGGCAGCTGTGTGTAAAGACGTGGAGGCTCCT       CAAATCAACTGTCCTAAGGACATAGAGGCTAAGACTCTGGAACAGCAAGATTCTGCCAATGTTACCTG       GCAGATTCCAACAGCTAAAGACAACTCTGGTGAAAAGGTGTCAGTCCACGTTCATCCAGCTTTCACCC       CACCTTACCTTTTCCCAATTGGAGATGTTGCTATCGTATACACGGCAACTGACCTATCCGGCAACCAG       GCCAGCTGCATTTTCCATATCAAGGTTATTGATGCAGAACCACCTGTCATAGACTGGTGCAGATCTCC       ACCTCCCGTCCAGGTCTCGGAGAAGGTACATGCCGCAAGCTGGGATGAGCCTCAGTTCTCAGACAACT       CAGGTGCTGAATTGGTCATTACCAGAAGTCATACACAAGGAGACCTTTTCCCTCAAGGGGAGACTATA       GTACAGTATACAGCCACTGACCCCTCAGGCAATAACAGGACATGTGATATCCATATTGTCATAAAAGG       TTCTCCCTGTGAAATTCCATTCACACCTGTAAATGGGGATTTTATATGCACTCCAGATAATACTGGAG       TCAACTGTACATTAACTTGCTTGGAGGGCTATGATTTCACAGAAGGGTCTACTGACAAGTATTATTGT       GCTTATGAAGATGGCGTCTGGAAACCAACATATACCACTGAATGGCCAGACTGTGCCAGTAAGCGTTT       TGCAAACCACGGGTTCAAGTCCTTTGAGATGTTCTACAAAGCAGCTCGTTGTGATGACACAGATCTGA       TGAAGAAGTTTTCTGAAGCATTTGAGACGACCCTGGGAAAAATGGTCCCATCATTTTGTAGTGATGCA       GAGGACATTGACTGCAGACTGGAGGAGAACCTGACCAAAAAATATTGCCTAGAATATAATTATGACTA       TGAAAATGGCTTTGCAATTGGTCCAGGTGGCTGGGGTGCAGCTAATAGGCTGGATTACTCTTACGATG       ACTTCCTGGACACTGTGCAAGAAACAGCCACAAGCATCGGCAATGCCAAGTCCTCACGGATTAAAAGA       AGTGCCCCATTATCTGACTATAAAATTAAGTTAATTTTTAACATCACAGCTAGTGTGCCATTACCCGA       TGAAAGAAATGATACCCTTGAATGGGAAAATCAGCAACGACTCCTTCAGACATTGGAAACTATCACAA       ATAAACTGAAAAGGACTCTCAACAAAGACCCCATGTATTCCTTTCAGCTTGCATCAGAAATACTTATA       GCCGACAGCAATTCATTAGAAACAAAAAAGGCTTCCCCCTTCTGCAGACCAGGCTCAGTGCTGAGAGG       GCGTATGTGTGTCAATTGCCCTTTGGGAACCTATTATAATCTGGAACATTTCACCTGTGAAAGCTGCC       GGATCGGATCCTATCAAGATGAAGAAGGGCAACTTGAGTGCAAGCTTTGCCCCTCTGGGATGTACACG       GAATATATCCATTCAAGAAACATCTCTGATTGTAAAGCTCAGTGTAAACAAGGCACCTACTCATACAG       TGGACTTGAGACTTGTGAATCGTGTCCACTGGGCACTTATCAGCCAAAATTTGGTTCCCGGAGCTGCC       TCTCGTGTCCAGAAAACACCTCAACTGTGAAAAGAGGAGCCGTGAACATTTCTGCATGTGGAGTTCCT       TGTCCAGAAGGAAAATTCTCGCGTTCTGGGTTAATGCCCTGTCACCCATGTCCTCGTGACTATTACCA       ACCTAATGCAGGGAAGGCCTTCTGCCTGGCCTGTCCCTTTTATGGAACTACCCCATTCGCTGGTTCCA       GATCCATCACAGAATGTTCAAGTTTTAGTTCAACTTTCTCAGCGGCAGAGGAAAGTGTGGTGCCCCCT       GCCTCTCTTGGACATATTAAAAAGAGGCATGAAATCAGCAGTCAGGCAAGTCATGAATGCTTCTTTAA       CCCTTGCCACAATAGTGGAACCTGCCAGCAACTTGGGCGTGGTTATGTTTGTCTCTGTCCACTTGGAT       ATACAGGTTTAAAGTGTGAAACAGACATCGATGAGTGCAGCCCACTGCCTTGCCTCAACAATGGAGTT       TGTAAAGACCTAGTTGGGGAATTCATTTGTGAGTGCCCATCAGGTTACACAGGTAAGCACTGTGAATT       GAACATCAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTCAT       ACAGTTGTAAATGTCAGCCAGGATTTTCAGGCAAAGGTGTGAAAACAGGTATGTATCAACTCAGTGTT       ATTAATAACCTTAATAATGCAGTCTGTGAAGACCAGGTTGGGGGATTCTTGTGCAAATGCCCACCTGG       ATTTTTGGGTACCCGATGTGGAAAGAACGTCGATGAGTGTCTCAGTCAGCCATGCAAAAATGGAGCTA       CCTGTAAAGACGGTGCCAATAGCTTCAGGTGCCTGTGTGCAGCTGGCTTCACAGGATCACACTGTGAA       TTGAACATCAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTC       ATACAGTTGTAAATGTCAGCCAGGATTTTCAGGCAAAAGGTGTGAAACAGAACAGTCTACAGGCTTTA       ACCTGGATTTTGAAGTTTCTGGCATCTATGGATATGTCATGCTAGATGGCATGCTCCCATCTCTCCAT       GCTCTAACCTGTACCTTCTGGATGAAATCCTCTGACGACATGAACTATGGAACACCAATCTCCTATGC       AGTTGATAACGGCAGCGACAATACCTTGCTCCTGACTGATTATAACGGGTGGGTTCTTTATGTGAATG       GCAGGGAAAAGATAACAAACTGTCCCTCGGTGAATGATGGCAGATGGCATCATATTGCAATCACTTGG       ACAAGTACTGGTGGAGCCTGGAGGGTCTATATAAATGGGGAATTATCTGACGGTGGTACTGGCCTCTC       CATTGGCAAAGCCATACCTGGTGGCGGTGCATTAGTTCTTGGGCAAGAGCAAGACAAAAAAGGAGAGG       GGTTCAACCCGGCTGAGTCTTTTGTGGGCTCCATAAGCCAGCTCAACCTCTGGGACTATGTCCTGTCT       CCACAGCAGGTGAAGTCACTGGCTACCTCCTGCCCAGAGGAACTCAGTAAAGGAAACGTGTTAGCATG       GCCTGATTTCTTGTCAGGAATTGTGGGGAAAGTGAAGATCGATTCTAAGAGCATATTTTGTTCTGATT       GCCCACGCTTGGGAGGGTCAGTGCCTCATCTGAGAACTGCATCTGAAGATTTAAAACCAGGTTCCAAA       GTCAATCTGTTCTGTGAACCAGGCTTCCAGCTGGTCGGGAACCCTGTGCAGTACTGTCTGAATCAAGG       ACAGTGGACACAACCACTCCCCCACTGTGAACGCATTCGCTGTGGGGTGCCACCTCCTTTGGAGAATG       GCTTCCATTCAGCCGATGACTTCTATGCTGGCAGCACAGTAACCTACCAGTGCAACAATGGCTACTAT       CTATTGGGTGACTCAAGGATGTTCTGTACAGATAATGGGAGCTGGAACGGCGTTTCACCATCCTGCTT       AGATGTCGATGAGTGTGCAGTTGGATCAGATTGTAGTGAGCATGCTTCTTGCCTGAACGTAGATGGAT       CCTACATATGTTCATGTGTCCCACCGTACACAGGAGATGGGAAAAACTGTGCAGAACCTATAAAATGT       AAGGCTCCAGGAAATCCGGAAAATGGCCACTCCTCAGGTGAGATTTATACAGTAGGTGCCGAAGTCAC       ATTTTCGTGTCAGGAAGGATACCAGTTGATGGGAGTAACCAAAATCACATGTTTGGAGTCTGGAGAAT       GGAATCATCTAATACCATATTGTAAAGCTGTTTCATGTGGTAAACCGGCTATTCCAGAAAATGGTTGC       ATTGAGGAGTTAGCATTTACTTTTGGCAGCAAAGTGACATATAGGTGTAATAAAGGATATACTCTGGC       CGGTGATAAAGAATCATCCTGTCTTGCTAACAGTTCTTGGAGTCATTCCCCTCCTGTGTGTGAACCAG       TGAAGTGTTCTAGTCCGGAAAATATAAATAATGGAAAATATATTTTGAGTGGGCTTACCTACCTTTCT       ACTGCATCATATTCATGCGATACAGGATACAGCTTACAGGGCCCTTCCATTATTGAATGCACGGCTTC       TGGCATCTGGGACAGAGCGCCACCTGCCTGTCACCTCGTCTTCTGTGGAGAACCACCTGCCATCAAAG       ATGCTGTCATTACGGGGAATAACTTCACTTTCAGGAACACCGTCACTTACACTTGCAAAGAAGGCTAT       ACTCTTGCTGGTCTTGACACCATTGAATGCCTGGCCGACGGCAAGTGGAGTAGAAGTGACCAGCAGTG       CCTGGCTGTCTCCTGTGATGAGCCACCCATTGTGGACCACGCCTCTCCAGAGACTGCCCATCGGCTCT       TTGGAGACATTGCATTCTACTACTGCTCTGATGGTTACAGCCTAGCAGACAATTCCCAGCTTCTCTGC       AATGCCCAGGGCAAGTGGGTACCCCCAGAAGGTCAAGACATGCCCCGTTGTATAGCTCATTTCTGTGA       AAAACCTCCATCGGTTTCCTATAGCATCTTGGAATCTGTGAGCAAAGCAAAATTTGCAGCTGGCTCAG       TTGTGAGCTTTAAATGCATGGAAGGCTTTGTACTGAACACCTCAGCAAAGATTGAATGTATGAGAGGT       GGGCAGTGGAACCCTTCCCCCATGTCCATCCAGTGCATCCCTGTGCGGTGTGGAGAGCCACCAAGCAT       CATGAATGGCTATGCAAGTGGATCAAACTACAGTTTTGGAGCCATGGTGGCTTACAGCTGCAACAAGG       GGTTCTACATCAAAGGGGAAAAGAAGAGCACCTGCGAAGCCACAGGGCAGTGGAGTAGTCCTATACCG       ACGTGCCACCCGGTATCTTGTGGTGAACCACCTAAGGTTGAGAATGGCTTTCTGGAGCATACAACTGG       CAGGATCTTTGAGAGTGAAGTGAGGTATCAGTGTAACCCGGGCTATAAGTCAGTCGGAAGTCCTGTAT       TTGTCTGCCAAGCCAATCGCCACTGGCACAGTGAATCCCCTCTGATGTGTGTTCCTCTCGACTGTGGA       AAACCTCCCCCGATCCAGAATGGCTTCATGAAAGGAGAAAACTTTGAAGTAGGGTCCAAGGTTCAGTT       TTTCTGTAATGAGGGTTATGAGCTTGTTGGTGACAGTTCTTGGACATGTCAGAAATCTGGCAAATGGA       ATAAGAAGTCAAATCCAAAGTGCATGCCTGCCAAGTGCCCAGAGCCGCCCCTCTTGGAAAACCAGCTA       GTATTAAAGGAGTTGACCACCGAGGTAGGAGTTGTGACATTTTCCTGTAAAGAAGGGCATGTCCTGCA       AGGCCCCTCTGTCCTGAAATGCTTGCCATCCCAGCAATGGAATGACTCTTTCCCTGTTTGTAAGATTG       TTCTTTGTGCCCCACCTCCCCTAATTTCCTTTGGTGTCCCCATTCCTTCTTCTGCTCTTCATTTTGGA       AGTACTGTCAAGTATTCTTGTGTAGGTGGGTTTTTCCTAAGAGGAAATTCTACCACCCTCTGCCAACC       TGATGGCACCTGGAGCTCTCCACTGCCAGAATGTGTTCCAGTAGAATGTCCCCAACCTGAGGAAATCC       CCAATGGAATCATTGATGTGCAAGGCCTTGCCTATCTCAGCACAGCTCTCTATACCTGCAAGCCAGGC       TTTGAATTGGTGGGAAATACTACCACCCTTTGTGGAGAAAATGGTCACTGGCTTGGAGGAAAACCAAC       ATGTAAAGCCATTGAGTGCCTGAAACCCAAGGAGATTTTGAATGGCAAATTCTCTTACACGGACCTAC       ACTATGGACAGACCGTTACCTACTCTTGCAACCGAGGCTTTCGGCTCGAAGGTCCCAGTGCCTTGACC       TGTTTAGAGACAGGTGATTGGGATGTAGATGCCCCATCTTGCAATGCCATCCACTGTGATTCCCCACA       ACCCATTGAAAATGGTTTTGTAGAAGGTGCAGATTACAGCTATGGTGCCATAATCATCTACAGTTGCT       TCCCTGGGTTTCAGGTGGCTGGTCATGCCATGCAGACCTGTGAAGAGTCAGGATGGTCAAGTTCCATC       CCAACATGTATGCCAATAGACTGTGGCCTCCCTCCTCATATAGATTTTGGAGACTGTACTAAACTCAA       AGATGACCAGGGATATTTTGAGCAAGAAGACGACATGATGGAAGTTCCATATGTGACTCCTCACCCTC       CTTATCATTTGGGAGCAGTGGCTAAAACCTGGGAAAATACAAAGGAGTCTCCTGCTACACATTCATCA       AACTTTCTGTATGGTACCATGGTTTCATACACCTGTAATCCAGGATATGAACTTCTGGGGAACCCTGT       GCTGATCTGCCAGGAAGATGGAACTTGGAATGGCAGTGCACCATCCTGCATTTCAATTGAATGTGACT       AGCTGTAAACCTGGACACATTCTAGCAGGCTCTGACTTAAGGCTTTGTCTAGAGAATAGAAAGTGGAG       TGGTGCCTCCCCACGCTGTGAAGCCATTTCATGCAAAAAGCCAAATCCAGTCATGAATGGATCCATCA       AAGGAAGCAACTACACATACCTGAGCACGTTGTACTATGAGTGTGACCCCGGATATGTGCTGAATGGC       ACTGAGAGGAGAACATGCCAGGATGACAAAAACTGGGATGAGGATGAGCCCATTTGCATTCCTGTGGA       CTGCAGTTCACCCCCAGTCTCAGCCAATGGCCAGGTGAGAGGAGACGAGTACACATTCCAAAAAGAGA       TTGAATACACTTGCAATGAAGGGTTCTTGCTTGAGGGAGCCAGGAGTCGGGTTTGTCTTGCCAATGGA       AGTTGGAGTGGAGCCACTCCCGACTGTGTGCCTGTCAGATGTGCCACCCCGCCACAACTGGCCAATGG       GGTGACGGAAGGCCTGGACTATGGCTTCATGAAGGAAGTAACATTCCACTGTCACGAGGGCTACATCT       TGCACGGTGCTCCAAAACTCACCTGTCAGTCAGATGGCAACTGGGATGCAGAGATTCCTCTCTGTAAA       CCAGTCAACTGTGGACCTCCTGAAGATCTTGCCCATGGTTTCCCTAATGGTTTTTCCTTTATTCATGG       GGGCCATATACAGTATCAGTGCTTTCCTGGTTATAAGCTCCATGGAAATTCATCAAGAAGGTGCCTCT       CCAATGGCTCCTGGAGTGGCAGCTCACCTTCCTGCCTGCCTTGCAGATGTTCCACACCAGTAATTGAA       TATGGAACTGTCAATGGGACAGATTTTGACTGTGGAAAGGCAGCCCGGATTCAGTGCTTCAAAGGCTT       CAAGCTCCTAGGACTTTCTGAAATCACCTGTGAAGCCGATGGCCAGTGGAGCTCTGGGTTCCCCCACT       GTGAACACACTTCTTGTGGTTCTCTTCCAATGATACCAAATGCGTTCATCAGTGAGACCAGCTCTTGG       AAGGAAAATGTGATAACTTACAGCTGCAGGTCTGGATATGTCATACAAGGCAGTTCAGATCTGATTTG       TACAGAGAAAGGGGTATGGAGCCAGCCTTATCCAGTCTGTGAGCCCTTGTCCTGTGGGTCCCCACCGT       CTGTCGCCAATGCAGTGGCAACTGGAGAGGCACACACCTATGAAAGTGAAGTGAAACTCAGATGTCTG       GAAGGTTATACGATGGATACAGATACAGATACATTCACCTGTCAGAAAGATGGTCGCTGGTTCCCTGA       GAGAATCTCCTGCAGTCCTAAAAAATGTCCTCTCCCGGAAAACATAACACATATACTTGTACATGGGG       ACGATTTCAGTGTGAATAGGCAAGTTTCTGTGTCATGTGCAGAAGGGTATACCTTTGAGGGAGTTAAC       ATATCAGTATGTCAGCTTGATGGAACCTGGGAGCCACCATTCTCCGATGAATCTTGCAGTCCAGTTTC       TTGTGGGAAACCTGAAAGTCCAGAAACATGGATTTGTGGTTGGCAGTAAATACACCTTTGAAAGCACA       TTATTTATCAGTGTGAGCCTGGCTATGAACTAGAGGGGAACAGGGAACGTGTCTGCCAGGAGAACAGA       CAGTGGAGTGGAGGGGTGGCAATATGCAAAGAGACCAGGTGTGAAACTCCACTTGAATTTCTCAATGG       GAAAGCTGACATTGAAAACAGGACGACTGGACCCAACGTGGTATATTCCTGCAACAGAGGCTACAGTC       TTGAAGGGCCATCTGAGGCACACTGCACAGAAAATGGAACCTGGAGCCACCCAGTCCCTCTCTGCAAA       CCAAATCCATGCCCTGTTCCTTTTGTGATTCCCGAGAATGCTCTGCTGTCTGAAAAGGAGTTTTATGT       TGATCAGAATGTGTCCATCAAATGTAGGGAAGGTTTTCTGCTGCAGGGCCACGGCATCATTACCTGCA       ACCCCGACGAGACGTGGACACAGACAAGCGCCAAATGTGAAAAAATCTCATGTGGTCCACCAGCTCAC       GTAGAAAATGCAATTGCTCGAGGCGTACATTATCAATATGGAGACATGATCACCTACTCATGTTACAG       TGGATACATGTTGGAGGGTTTCCTGAGGAGTGTTTGTTTAGAAAATGGAACATGGACATCACCTCCTA       TTTGCAGAGCTGTCTGTCGATTTCCATGTCAGAATGGGGGCATCTGCCAACGCCCAAATGCTTGTTCC       TGTCCAGAGGGCTGGATGGGGCGCCTCTGTGAAGAACCAATCTGCATTCTTCCCTGTCTGAACGGAGG       TCGCTGTGTGGCCCCTTACCAGTGTGACTGCCCGCCTGGCTGGACGGGGTCTCGCTGTCATACAGCTG       TTTGCCAGTCTCCCTGCTTAAATGGTGGAAAATGTGTAAGACCAAACCGATGTCACTGTCTTTCTTCT       TGGACGGGACATAACTGTTCCAGGAAAAGGAGGACTGGGTTTTAACCACTGCACGACCATCTGGCTCT       CCCAAAAGCAGGATCATCTCTCCTCGGTAGTGCCTGGGCATCCTGGAACTTATGCAAAGAAAGTCCAA       CATGGTGCTGGGTCTTGTTTAGTAAACTTGTTACTTGGGGTTACTTTTTTTATTTTGTGATATATTTT       GTTATTCCTTGTGACATACTTTCTTACATGTTTCCATTTTTAAATATGCCTGTATTTTCTATATAAAA       ATTATATTAAATAGATGCTGCTCTACCCTCACAAAATGTACATATTCTGCTGTCTATTGGGAAAGTTC       CTGGTACACATTTTTATTCAGTTACTTAAAATGATTTTTCCATTAAAGTATATTTTGCTACTAAATAA       AAAAAA                                                 NOV8m, SNP13374257 of   SEQ ID NO: 202       MW at 389982.5kD                                 CG50646-04, Protein Sequence   SNP Pos: 2381   3570 aa   SNP Change: Thr to Ala                             MRRICAACWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRVERLGQAFR           VRLLRELSERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRVDY       ISTRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPI       AASLRDSGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALVALCHMLFVDLPSGSFIQDD       MVHCSYLCDEGKDCCDRMGSCKCGKHTGHFECICEKGYNGKGLQYDCTVCPSGTYKPEGSPGGISSCI       PCPDENHTSPPGSTSPEDCVCREGYPASGQTCEVVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPG       FDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK       LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCT       TSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEKVSVHVHPAFTPPY       LFPIGDVAIVYTATDLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWDEPQFSDNSGA       ELVITRSHTQGDLFPQGETIVQYTATDPSGNNRTCDIHIVIKGSPCEIPFTPVNGDFICTPDNTGVNC       TLTCLEGYDFTEGSTDKYYCAYEDGVWKPTYTTEWPDCASKRFANRGFKSFEMFYKAARCDDTDLMKK       FSEAFETTLGKMVPSFCSDAEDIDCPLEENLTKKYCLEYNYDYENGFAIGPGGWGAANRLDYSYDDFL       DTVQETATSIGNAKSSRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKL       KRTLNKDPMYSFQLASEILIADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRIG       SYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSC       TECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQASHECFFNPCHNSGTCQQLGRGYVCLCPLGYTG       LKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGKHCELNINECQSNPCRNQATCVDELNSYSC       KCQPGFSGKRCETGMYQLSVINNLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCK       DGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLD       FEVSGIYGYVMLDGMLPSLHALTCTFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGRE       KITNCPSVNDGRWHHIAITWTSTGGAWRVYINGELSDGGTGLSIGKAIPGGGALVLGQEQDKKGEGFN       PAESFVGSISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPR       LGGSVPHLRTASEDLKPGSKVNLFCEPGFQLVGNPVQYCLNQGQWTQPLPHCERIRCGVPPPLENGFH       SADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYI       CSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNH       LIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKC       SSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAV       ITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGD       IAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVS       FKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFY       IKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVC       QANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKK       SNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLC       APPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNG       IIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYG       QTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPG       FQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDNMEVPYVTPHPPYH       LGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPT       APENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGS       NYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEY       TCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHG       APKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNG       SWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEH       TSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVA       NAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDF       SVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKFESPEHGFVVGSKYTFESTIIY       QCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEG       PSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPD       ETWTQTSAKCEKISCGPPAHVENAIARGVHYGYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICR       AVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQ       SPCLNGGKCVRPNRCHCLSSWTGHNCSRKRRTGF                                                 SEQ ID NO: 203   11158 bp                                 NOV8n, SNP13382479 of   ORF Start: ATG at 77   ORF Stop: TAA at 10787                             CG50646-04, DNA Sequence   SNP Pos: 9649   SNP Change: A to T                             CAATTGGTCTAGGGTCTCCCCCATTGGAATATCCATCAGTGATGAGAAATACAACGTTTGTTGAGTTT           TCTCTAGCATGAGAAGAATTTGCGCGGCTTGCTGGGGTCTGGCGCTCGTTTCGGGCTGGGCGACCTTT       CAGCAGATGTCCCCGTCGCGCAATTTCAGCTTCCGCCTCTTCCCCGAGACCCCGCCCGGGGCCCCCCG       CGTTCCGCGTGCGGCTGCTGCGGGAGCTCAGCGAGCGCCTGGAGCTTGTCTTCCTGGTGGATGATTCG       TCCAGCGTGGGCGAAGTCAACTTCCGCAGCGAGCTCATGTTCGTCCGCAAGCTGCTGTCCGACTTCCC       TCGATTACATCTCCACCCGCCGCGCGCGCCAGCACAAGTGCGCGCTGCTCCTCCAAGAGATCCCTGCC       ATCTCCTACCGAGGTGGCGGCACCTACACCAAGGGCGCCTTCCAGCAAGCCGCGCAAATTCTTCTTCA       TGCTAGAGAAAACTCAACAAAAGTTGTATTTCTCATCACTGATGGATATTCCAATGGGGGAGACCCTA       GACCAATTGCAGCGTCACTGCGAGATTCAGGAGTGGAGATCTTCACTTTTGGCATATGGCAAGGGAAC       ATTCGAGAGCTGAATGACATGGCTTCCACCCCAAAGGAGGAGCACTGTTACCTGCTACACAGTTTTGA       AGAATTTGAGGCTTTAGTCGCCCTCTGTCATATGTTATTTGTAGATCTACCTTCTGGGAGTTTTATTC       AAGATGATATGGTCCACTGCTCATATCTTTGTGATGAAGGCAAGGACTGCTGTGACCGAATGGGAAGC       TGCAAATGTGGGAAACACACAGGCCATTTTGAGTGCATCTGTGAAAAGGGGTATAACGGGAAAGGTCT       GCAGTATGACTGCACAGTTTGCCCATCGGGGACATACAAACCTGAAGGCTCACCAGGAGGAATCAGCA       GTTGCATTCCATGTCCTGATGAAAATCACACCTCTCCACCTGGAAGCACATCCCCTGAAGACTGTGTC       TGCAGAGAGGGATACAGGGCATCTGGCCAGACCTGTGAAGTTGTCCACTGCCCTGCCCTGAAGCCTCC       CGAAAATGGTTACTTTATCCAAAACACTTGCAACAACCACTTCAATGCAGCCTGTGGGGTCCGATGTC       ACCCTGGATTTGATCTTGTGGGAAGCAGCATCATCTTATGTCTACCCAATGGTTTGTGGTCCGGTTCA       GAGAGCTACTGCAGAGTAAGAACATGTCCTCATCTCCGCCAGCCGAAACATGGCCACATCAGCTGTTC       TACAAGGGAAATGTTATATAAGACAACATGTTTGGTTGCCTGTGATGAAGGGTACAGGCTAGAAGGCA       GTGATAAGCTTACTTGTCAAGGAAACAGCCAGTGGGATGGGCCAGAACCCCGGTGTGTGGAGCGCCAC       TGTTCCACCTTTCAGATGCCCAAAGATGTCATCATATCCCCCCACAACTGTGGCAAGCAGCCAGCCAA       ATTTGGGACGATCTGCTATGTAAGTTGCCGCCAAGGGTTCATTTTATCTGGAGTCAAAGAAATGCTGA       GATGTACCACTTCTGGAAAATGGAATGTCGGAGTTCAGGCAGCTGTGTGTAAAGACGTGGAGGCTCCT       CAAATCAACTGTCCTAAGGACATAGAGGCTAAGACTCTGGAACAGCAAGATTCTGCCAATGTTACCTG       GCAGATTCCAACAGCTAAAGACAACTCTGGTGAAAAGGTGTCAGTCCACGTTCATCCAGCTTTCACCC       CACCTTACCTTTTCCCAATTGGAGATGTTGCTATCGTATACACGGCAACTGACCTATCCGGCAACCAG       GCCAGCTGCATTTTCCATATCAAGGTTATTGATGCAGAACCACCTGTCATAGACTGGTGCAGATCTCC       ACCTCCCGTCCAGGTCTCGGAGAAGGTACATGCCGCAAGCTGGGATGAGCCTCAGTTCTCAGACAACT       CAGGTGCTGAATTGGTCATTACCAGAAGTCATACACAAGGAGACCTTTTCCCTCAAGGGGAGACTATA       GTACAGTATACAGCCACTGACCCCTCAGGCAATAACAGGACATGTGATATCCATATTGTCATAAAAGG       TTCTCCCTGTGAAATTCCATTCACACCTGTAAATGGGGATTTTATATGCACTCCAGATAATACTGGAG       TCAACTGTACATTAACTTGCTTGGAGGGCTATGATTTCACAGAAGGGTCTACTGACAAGTATTATTGT       GCTTATGAAGATGGCGTCTGGAAACCAACATATACCACTGAATGGCCAGACTGTGCCAGTAAGCGTTT       TGCAAACCACGGGTTCAAGTCCTTTGAGATGTTCTACAAAGCAGCTCGTTGTGATGACACAGATCTGA       TGAAGAAGTTTTCTGAAGCATTTGAGACGACCCTGGGAAAAATGGTCCCATCATTTTGTAGTGATGCA       GAGGACATTGACTGCAGACTGGAGGAGAACCTGACCAAAAAATATTGCCTAGAATATAATTATGACTA       TGAAAATGGCTTTGCAATTGGTCCAGGTGGCTGGGGTGCAGCTAATAGGCTGGATTACTCTTACGATG       ACTTCCTGGACACTGTGCAAGAAACAGCCACAAGCATCGGCAATGCCAAGTCCTCACGGATTAAAAGA       AGTGCCCCATTATCTGACTATAAAATTAAGTTAATTTTTAACATCACAGCTAGTGTGCCATTACCCGA       TGAAAGAAATGATACCCTTGAATGGGAAAATCAGCAACGACTCCTTCAGACATTGGAAACTATCACAA       ATAAACTGAAAAGGACTCTCAACAAAGACCCCATGTATTCCTTTCAGCTTGCATCAGAAATACTTATA       GCCGACAGCAATTCATTAGAAACAAAAAAGGCTTCCCCCTTCTGCAGACCAGGCTCAGTGCTGAGAGG       GCGTATGTGTGTCAATTGCCCTTTGGGAACCTATTATAATCTGGAACATTTCACCTGTGAAAGCTGCC       GGATCGGATCCTATCAAGATGAAGAAGGGCAACTTGAGTGCAAGCTTTGCCCCTCTGGGATGTACACG       GAATATATCCATTCAAGAAACATCTCTGATTGTAAAGCTCAGTGTAAACAAGGCACCTACTCATACAG       TGGACTTGAGACTTGTGAATCGTGTCCACTGGGCACTTATCAGCCAAAATTTGGTTCCCGGAGCTGCC       TCTCGTGTCCAGAAAACACCTCAACTGTGAAAAGAGGAGCCGTGAACATTTCTGCATGTGGAGTTCCT       TGTCCAGAAGGAAAATTCTCGCGTTCTGGGTTAATGCCCTGTCACCCATGTCCTCGTGACTATTACCA       ACCTAATGCAGGGAAGGCCTTCTGCCTGGCCTGTCCCTTTTATGGAACTACCCCATTCGCTGGTTCCA       GATCCATCACAGAATGTTCAAGTTTTAGTTCAACTTTCTCAGCGGCAGAGGAAAGTGTGGTGCCCCCT       GCCTCTCTTGGACATATTAAAAAGAGGCATGAAATCAGCAGTCAGGCAAGTCATGAATGCTTCTTTAA       CCCTTGCCACAATAGTGGAACCTGCCAGCAACTTGGGCGTGGTTATGTTTGTCTCTGTCCACTTGGAT       ATACAGGTTTAAAGTGTGAAACAGACATCGATGAGTGCAGCCCACTGCCTTGCCTCAACAATGGAGTT       TGTAAGACCTAGTTGGGGAAATTCATTTGTGAGTGCCCATCAGGTTACACAGGTAAGCACTGTGAATT       GAACATCAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTCAT       ACAGTTGTAAATGTCAGCCAGGATTTTCAGGCAAAAGGTGTGAAACAGGTATGTATCAACTCAGTGTT       ATTAATAACCTTAATAATGCAGTCTGTGAAGACCAGGTTGGGGGATTCTTGTGCAAATGCCCACCTGG       ATTTTTGGGTACCCGATGTGGAAAGAACGTCGATGAGTGTCTCAGTCAGCCATGCAAAAATGGAGCTA       CCTGTAAAGACGGTGCCAATAGCTTCAGGTGCCTGTGTGCAGCTGGCTTCACAGGATCACACTGTGAA       TTGAACATCAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTC       ATACAGTTGTAAATGTCAGCCAGGATTTTCAGGCAAAAGGTGTGAAACAGAACAGTCTACAGGCTTTA       ACCTGGATTTTGAAGTTTCTGGCATCTATGGATATGTCATGCTAGATGGCATGCTCCCATCTCTCCAT       GCTCTAACCTGTACCTTCTGGATGAAATCCTCTGACGACATGAACTATGGAACACCAATCTCCTATGC       AGTTGATAACGGCAGCGACAATACCTTGCTCCTGACTGATTATAACGGGTGGGTTCTTTATGTGAATG       GCAGGGAAAAGATAACAAACTGTCCCTCGGTGAATGATGGCAGATGGCATCATATTGCAATCACTTGG       ACAAGTACTGGTGGAGCCTGGAGGGTCTATATAAATGGGGAATTATCTGACGGTGGTACTGGCCTCTC       CATTGGCAAAGCCATACCTGGTGGCGGTGCATTAGTTCTTGGGCAAGAGCAAGACAAAAAAGGAGAGG       GGTTCAACCCGGCTGAGTCTTTTGTGGGCTCCATAAGCCAGCTCAACCTCTGGGACTATGTCCTGTCT       CCACAGCAGGTGAAGTCACTGGCTACCTCCTGCCCAGAGGAACTCAGTAAAGGAAACGTGTTAGCATG       GCCTGATTTCTTGTCAGGAATTGTGGGGAAAGTGAAGATCGATTCTAAGAGCATATTTTGTTCTGATT       GCCCACGCTTGGGAGGGTCAGTGCCTCATCTGAGAACTGCATCTGAAGATTTAAAACCAGGTTCCAAA       ACAGTGGACACAACCACTCCCCCACTGTGAACGCATTCGCTGTGGGGTGCCACCTCCTTTGGAGAATG       GCTTCCATTCAGCCGATGACTTCTATGCTGGCAGCACAGTAACCTACCAGTGCAACAATGGCTACTAT       CTATTGGGTGACTCAAGGATGTTCTGTACAGATAATGGGAGCTGGAACGGCGTTTCACCATCCTGCTT       AGATGTCGATGAGTGTGCAGTTGGATCAGATTGTAGTGAGCATGCTTCTTGCCTGAACGTAGATGGAT       CCTACATATGTTCATGTGTCCCACCGTACACAGGAGATGGGAAAAACTGTGCAGAACCTATAAAATGT       AAGGCTCCAGGAAATCCGGAAAATGGCCACTCCTCAGGTGAGATTTATACAGTAGGTGCCGAAGTCAC       ATTTTCGTGTCAGGAAGGATACCAGTTGATGGGAGTAACCAAAATCACATGTTTGGAGTCTGGAGAAT       GGAATCATCTAATACCATATTGTAAAGCTGTTTCATGTGGTAAACCGGCTATTCCAGAAAATGGTTGC       ATTGAGGAGTTAGCATTTACTTTTGGCAGCAAAGTGACATATAGGTGTAATAAAGGATATACTCTGGC       CGGTGATAAAGAATCATCCTGTCTTGCTAACAGTTCTTGGAGTCATTCCCCTCCTGTGTGTGAACCAG       TGAAGTGTTCTAGTCCGGAAAATATAAATAATGGAAAATATATTTTGAGTGGGCTTACCTACCTTTCT       ACTGCATCATATTCATGCGATACAGGATACAGCTTACAGGGCCCTTCCATTATTGAATGCACGGCTTC       TGGCATCTGGGACAGAGCGCCACCTGCCTGTCACCTCGTCTTCTGTGGAGAACCACCTGCCATCAAAG       ATGCTGTCATTACGGGGAATAACTTCACTTTCAGGAACACCGTCACTTACACTTGCAAAGAAGGCTAT       ACTCTTGCTGGTCTTGACACCATTGAATGCCTGGCCGACGGCAAGTGGAGTAGAAGTGACCAGCAGTG       CCTGGCTGTCTCCTGTGATGAGCCACCCATTGTGGACCACGCCTCTCCAGAGACTGCCCATCGGCTCT       AATGCCCAGGGCAAGTGGGTACCCCCAGAAGGTCAAGACATGCCCCGTTGTATAGCTCATTTCTGTGA       AAAACCTCCATCGGTTTCCTATAGCATCTTGGAATCTGTGAGCAAAGCAAAATTTGCAGCTGGCTCAG       TTGTGAGCTTTAAATGCATGGAAGGCTTTGTACTGAACACCTCAGCAAAGATTGAATGTATGAGAGGT       GGGCAGTGGAACCCTTCCCCCATGTCCATCCAGTGCATCCCTGTGCGGTGTGGAGAGCCACCAAGCAT       CATGAATGGCTATGCAAGTGGATCAAACTACAGTTTTGGAGCCATGGTGGCTTACAGCTGCAACAAGG       GGTTCTACATCAAAGGGGAAAAGAAGAGCACCTGCGAAGCCACAGGGCAGTGGAGTAGTCCTATACCG       ACGTGCCACCCGGTATCTTGTGGTGAACCACCTAAGGTTGAGAATGGCTTTCTGGAGCATACAACTGG       CAGGATCTTTGAGAGTGAAGTGAGGTATCAGTGTAACCCGGGCTATAAGTCAGTCGGAAGTCCTGTAT       TTGTCTGCCAAGCCAATCGCCACTGGCACAGTGAATCCCCTCTGATGTGTGTTCCTCTCGACTGTGGA       AAACCTCCCCCGATCCAGAATGGCTTCATGAAAGGAGAAAACTTTGAAGTAGGGTCCAAGGTTCAGTT       TTTCTGTAATGAGGGTTATGAGCTTGTTGGTGACAGTTCTTGGACATGTCAGAAATCTGGCAAATGGA       ATAAGAAGTCAAATCCAAAGTGCATGCCTGCCAAGTGCCCAGAGCCGCCCCTCTTGGAAAACCAGCTA       GTATTAAAGGAGTTGACCACCGAGGTAGGAGTTGTGACATTTTCCTGTAAAGAAGGGCATGTCCTGCA       AGGCCCCTCTGTCCTGAAATGCTTGCCATCCCAGCAATGGAATGACTCTTTCCCTGTTTGTAAGATTG       TTCTTTGTACCCCACCTCCCCTAATTTCCTTTGGTGTCCCCATTCCTTCTTCTGCTCTTCATTTTGGA       AGTACTGTCAAGTATTCTTGTGTAGGTGGGTTTTTCCTAAGAGGAAATTCTACCACCCTCTGCCAACC       TGATGGCACCTGGAGCTCTCCACTGCCAGAATGTGTTCCAGTAGAATGTCCCCAACCTGAGGAAATCC       CCAATGGAATCATTGATGTGCAAGGCCTTGCCTATCTCAGCACAGCTCTCTATACCTGCAAGCCAGGC       TTTGAATTGGTGGGAAATACTACCACCCTTTGTGGAGAAAATGGTCACTGGCTTGGAGGAAAACCAAC       ATGTAAAGCCATTGAGTGCCTGAAACCCAAGGAGATTTTGAATGGCAAATTCTCTTACACGGACCTAC       ACTATGGACAGACCGTTACCTACTCTTGCAACCGAGGCTTTCGGCTCGAAGGTCCCAGTGCCTTGACC       TGTTTAGAGACAGGTGATTGGGATGTAGATGCCCCATCTTGCAATGCCATCCACTGTGATTCCCCACA       ACCCATTGAAAATGGTTTTGTAGAAGGTGCAGATTACAGCTATGGTGCCATAATCATCTACAGTTGCT       TCCCTGGGTTTCAGGTGGCTGGTCATGCCATGCAGACCTGTGAAGAGTCAGGATGGTCAAGTTCCATC       CCAACATGTATGCCAATAGACTGTGGCCTCCCTCCTCATATAGATTTTGGAGACTGTACTAAACTCAA       AGATGACCAGGGATATTTTGAGCAAGAAGACGACATGATGGAAGTTCCATATGTGACTCCTCACCCTC       CTTATCATTTGGGAGCAGTGGCTAAAACCTGGGAAAATACAAAGGAGTCTCCTGCTACACATTCATCA       AACTTTCTGTATGGTACCATGGTTTCATACACCTGTAATCCAGGATATGAACTTCTGGGGAACCCTGT       GCTGATCTGCCAGGAAGATGGAACTTGGAATGGCAGTGCACCATCCTGCATTTCAATTGAATGTGACT       TGCCTACTGCTCCTGAAAATGGCTTTTTGCGTTTTACAGAGACTAGCATGGGAAGTGCTGTGCAGTAT       AGCTGTAAACCTGGACACATTCTAGCAGGCTCTGACTTAAGGCTTTGTCTAGAGAATAGAAAGTGGAG       TGGTGCCTCCCCACGCTGTGAAGCCATTTCATGCAAAAAGCCAAATCCAGTCATGAATGGATCCATCA       AAGGAAGCAACTACACATACCTGAGCACGTTGTACTATGAGTGTGACCCCGGATATGTGCTGAATGGC       ACTGAGAGGAGAACATGCCAGGATGACAAAAACTGGGATGAGGATGAGCCCATTTGCATTCCTGTGGA       CTGCAGTTCACCCCCAGTCTCAGCCAATGGCCAGGTGAGAGGAGACGAGTACACATTCCAAAAAGAGA       TTGAATACACTTGCAATGAAGGGTTCTTGCTTGAGGGAGCCAGGAGTCGGGTTTGTCTTGCCAATGGA       AGTTGGAGTGGAGCCACTCCCGACTGTGTGCCTGTCAGATGTGCCACCCCGCCACAACTGGCCAATGG       GGTGACGGAAGGCCTGGACTATGGCTTCATGAAGGAAGTAACATTCCACTGTCACGAGGGCTACATCT       TGCACGGTGCTCCAAAACTCACCTGTCAGTCAGATGGCAACTGGGATGCAGAGATTCCTCTCTGTAAA       CCAGTCAACTGTGGACCTCCTGAAGATCTTGCCCATGGTTTCCCTAATGGTTTTTCCTTTATTCATGG       GGGCCATATACAGTATCAGTGCTTTCCTGGTTATAAGCTCCATGGAAATTCATCAAGAAGGTGCCTCT       CCAATGGCTCCTGGAGTGGCAGCTCACCTTCCTGCCTGCCTTGCAGATGTTCCACACCAGTAATTGAA       TATGGAACTGTCAATGGGACAGATTTTGACTGTGGAAAGGCAGCCCGGATTCAGTGCTTCAAAGGCTT       CAAGCTCCTAGGACTTTCTGAAATCACCTGTGAAGCCGATGGCCAGTGGAGCTCTGGGTTCCCCCACT       GTGAACACACTTCTTGTGGTTCTCTTCCAATGATACCAAATGCGTTCATCAGTGAGACCAGCTCTTGG       AAGGAAAATGTGATAACTTACAGCTGCAGGTCTGGATATGTCATACAAGGCAGTTCAGATCTGATTTG       TACAGAGAAAGGGGTATGGAGCCAGCCTTATCCAGTCTGTGAGCCCTTGTCCTGTGGGTCCCCACCGT       CTGTCGCCAATGCAGTGGCAACTGGAGAGGCACACACCTATGAAAGTGAAGTGAAACTCAGATGTCTG       GAAGGTTATACGATGGATACAGATACAGATACATTCACCTGTCAGAAAGATGGTCGCTGGTTCCCTGA       GAGAATCTCCTGCAGTCCTAAAAAATGTCCTCTCCCGGAAAACATAACACATATACTTGTTCATGGGG       ACGATTTCAGTGTGAATAGGCAAGTTTCTGTGTCATGTGCAGAAGGGTATACCTTTGAGGGAGTTAAC       ATATCAGTATGTCAGCTTGATGGAACCTGGGAGCCACCATTCTCCGATGAATCTTGCAGTCCAGTTTC       TTGTGGGAAACCTGAAAGTCCAGAACATGGATTTGTGGTTGGCAGTAAATACACCTTTGAAAGCACAA       TTATTTATCAGTGTGAGCCTGGCTATGAACTAGAGGGGAACAGGGAACGTGTCTGCCAGGAGAACAGA       CAGTGGAGTGGAGGGGTGGCAATATGCAAAGAGACCAGGTGTGAAACTCCACTTGAATTTCTCAATGG       GAAAGCTGACATTGAAAACAGGACGACTGGACCCAACGTGGTATATTCCTGCAACAGAGGCTACAGTC       TTGAAGGGCCATCTGAGGCACACTGCACAGAAAATGGAACCTGGAGCCACCCAGTCCCTCTCTGCAAA       CCAAATCCATGCCCTGTTCCTTTTGTGATTCCCGAGAATGCTCTGCTGTCTGAAAAGGAGTTTTATGT       TGATCAGAATGTGTCCATCAAATGTAGGGAAGGTTTTCTGCTGCAGGGCCACGGCATCATTACCTGCA       ACCCCGACGAGACGTGGACACAGACAAGCGCCAAATGTGAAAAAATCTCATGTGGTCCACCAGCTCAC       GTAGAAAATGCAATTGCTCGAGGCGTACATTATCAATATGGAGACATGATCACCTACTCATGTTACAG       TGGATACATGTTGGAGGGTTTCCTGAGGAGTGTTTGTTTAGAAAATGGAACATGGACATCACCTCCTA       TTTGCAGAGCTGTCTGTCGATTTCCATGTCAGAATGGGGGCATCTGCCAACGCCCAAATGCTTGTTCC       TGTCCAGAGGGCTGGATGGGGCGCCTCTGTGAAGAACCAATCTGCATTCTTCCCTGTCTGAACGGAGG       TCGCTGTGTGGCCCCTTACCAGTGTGACTGCCCGCCTGGCTGGACGGGGTCTCGCTGTCATACAGCTG       TTTGCCAGTCTCCCTGCTTAAATGGTGGAAAATGTGTAAGACCAAACCGATGTCACTGTCTTTCTTCT       TGGACGGGACATAACTGTTCCAGGAAAAGGAGGACTGGGTTTTAACCACTGCACGACCATCTGGCTCT       CCCAAAAGCAGGATCATCTCTCCTCGGTAGTGCCTGGGCATCCTGGAACTTATGCAAAGAAAGTCCAA       CATGGTGCTGGGTCTTGTTTAGTAAACTTGTTACTTGGGGTTACTTTTTTTATTTTGTGATATATTTT       GTTATTCCTTGTGACATACTTTCTTACATGTTTCCATTTTTAAATATGCCTGTATTTTCTATATAAAA       ATTATATTAAATAGATGCTGCTCTACCCTCACAAAATGTACATATTCTGCTGTCTATTGGGAAAGTTC       CTGGTACACATTTTTATTCAGTTACTTAAAATGATTTTTCCATTAAAGTATATTTTGCTACTAAATAA       AAAAAA                                                 NOV8n, SNP13382479 of   SEQ ID NO: 204       MW at 390012.5kD                                 CG50646-04, Protein Sequence   SNP Pos: 3191   3570 aa   SNP Change: Val to Val                             MRRICAACWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRVERLGQAFR           VRLLRELSERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRVDY       ISTRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPI       AASLRDSGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALVALCHMLFVDLPSGSFIQDD       MVHCSYLCDEGKDCCDRMGSCKCGKHTGHFECICEKGYNGKGLQYDCTVCPSGTYKPEGSPGGISSCI       PCPDENHTSPPGSTSPEDCVCREGYFASGQTCEVVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPG       FDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYPLEGSDK       LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCT       TSGWNNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEKVSVHVHPAFTPPY       LFPIGDVAIVYTATDLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWDEPQFSDNSGA       ELVITRSHTQGDLFPQGETIVQYTATDPSGNNRTCDIHIVIKGSPCEIPFTPVNGDFICTPDNTGVNC       TLTCLEGYDFTEGSTDKYYCAYEDGVWKPTYTTEWPDCASKRFANHGFKSFEMFYKAARCDDTDLMKK       FSEAFETTLGKMVPSFCSDAEDIDCRLEENLTKKYCLEYNYDYENGFAIGPGGWGAANRLDYSFDDFL       DTVQETATSIGNAKSSRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKL       KRTLNKDPMYSFQLASEILIADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRIG       SYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSC       PENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSI       TECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQASHECFFNPCHNSGTCQQLGRGYVCLCPLGYTG       LKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGKHCELNINECQSNPCRNQATCVDELNSYSC       KCQPGFSGKRCETGMYQLSVINNLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCK       DGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLD       FEVSGIYGYVMLDGMLPSLHAITCTFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGRE       KITNCPSVNDGRWHHIAITWTSTGGAWRVYINGELSDGGTGLSIGKAIPGGGALVLGQEQDKKGEGFN       PAESFVGSISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPR       LGGSVPHLRTASEDLKPGSKVNLFCEPGFQLVGNPVQYCLNQGQWTQPLPHCERIRCGVPPPLENGFH       SADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYI       CSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNH       LIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKC       SSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAV       ITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGD       IAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVS       FKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFY       IKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVC       QANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKK       SNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLC       TPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNG       IIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYG       QTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPG       FQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYH       LGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPT       APENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGS       NYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEY       TCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHG       APKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNG       SWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEH       TSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVA       NAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDF       SVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIY       QCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEG       PSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPD       ETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICR       AVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQ       SPCLNGGKCVRPNRCHCLSSWTGHNCSRKRRTGF                                                 SEQ ID NO: 205   11158 bp                                 NOV8o, SNP13382480 of   ORF Start: ATG at 77   ORF Stop: TAA at 10787                             CG50646-04, DNA Sequence   SNP Pos: 10749   SNP Change: C to T                             GAATTGGTCTAGGGTCTCCCCCATTGGAATATCCATCAGTGATGAGAAATACAACGTTTGTTGAGTTT           TCTCTAGCATGAGAAGAATTTGCGCGGCTTGCTGGGGTCTGGCGCTCGTTTCGGGCTGGGCGACCTTT       CAGCAGATGTCCCCGTCGCGCAATTTCAGCTTCCGCCTCTTCCCCGAGACCGCGCCCGGGGCCCCCGG       GAGTATCCCCGCGCCGCCCGCTCCTGGCGACGAAGCGGCGGGGAGCAGAGTGGAGCGGCTGGGCCAGG       CGTTCCGCGTGCGGCTGCTGCGGGAGCTCAGCGAGCGCCTGGAGCTTGTCTTCCTGGTGGATGATTCG       TCCAGCGTGGGCGAAGTCAACTTCCGCAGCGAGCTCATGTTCGTCCGCAAGCTGCTGTCCGACTTCCC       CGTGGTGCCCACGGCCACGCGCGTGGCCATCGTGACCTTCTCGTCCAAGAACTACGTGGTGCCGCGCG       TCGATTACATCTCCACCCGCCGCGCGCGCCAGCACAAGTGCGCGCTGCTCCTCCAAGAGATCCCTGCC       ATCTCCTACCGAGGTGGCGGCACCTACACCAAGGGCGCCTTCCAGCAAGCCGCGCAAATTCTTCTTCA       TGCTAGAGAAAACTCAACAAAAGTTGTATTTCTCATCACTGATGGATATTCCAATGGGGGAGACCCTA       GACCAATTGCAGCGTCACTGCGAGATTCAGGAGTGGAGATCTTCACTTTTGGCATATGGCAAGAGAAC       ATTCGAGAGCTGAATGACATGGCTTCCACCCCAAAGGAGGAGCACTGTTACCTGCTACACAGTTTTGA       AGAATTTGAGGCTTTAGTCGCCCTCTGTCATATGTTATTTGTAGATCTACCTTCTGGGAGTTTTATTC       AAGATGATATGGTCCACTGCTCATATCTTTGTGATGAAGGCAAGGACTGCTGTGACCGAATGGGAAGC       TGCAAATGTGGGAAACACACAGGCCATTTTGAGTGCATCTGTGAAAAGGGGTATAACGGGAAAGGTCT       GCAGTATGACTGCACAGTTTGCCCATCGGGGACATACAAACCTGAAGGCTCACCAGGAGGAATCAGCA       GTTGCATTCCATGTCCTGATGAAAATCACACCTCTCCACCTGGAAGCACATCCCCTGAAGACTGTGTC       TGCAGAGAGGGATACAGGGCATCTGGCCAGACCTGTGAAGTTGTCCACTGCCCTGCCCTGAAGCCTCC       CGAAAATGGTTACTTTATCCAAAACACTTGCAACAACCACTTCAATGCAGCCTGTGGGGTCCGATGTC       ACCCTGGATTTGATCTTGTGGGAAGCAGCATCATCTTATGTCTACCCAATGGTTTGTGGTCCGGTTCA       GAGAGCTACTGCAGAGTAAGAACATGTCCTCATCTCCGCCAGCCGAAACATGGCCACATCAGCTGTTC       TACAAGGGAAATGTTATATAAGACAACATGTTTGGTTGCCTGTGATGAAGGGTACAGGCTAGAAGGCA       GTGATAAGCTTACTTGTCAAGGAAACAGCCAGTGGGATGGGCCAGAACCCCGGTGTGTGGAGCGCCAC       TGTTCCACCTTTCAGATGCCCAAAGATGTCATCATATCCCCCCACAACTGTGGCAAGCAGCCAGCCAA       ATTTGGGACGATCTGCTATGTAAGTTGCCGCCAAGGGTTCATTTTATCTGGAGTCAAAGAAATGCTGA       GATGTACCACTTCTGGAAAATGGAATGTCGGAGTTCAGGCAGCTGTGTGTAAAGACGTGGAGGCTCCT       CAAATCAACTGTCCTAAGGACATAGAGGCTAAGACTCTGGAACAGCAAGATTCTGCCAATGTTACCTG       GCAGATTCCAACAGCTAAAGACAACTCTGGTGAAAAGGTGTCAGTCCACGTTCATCCAGCTTTCACCC       CACCTTACCTTTTCCCAATTGGAGATGTTGCTATCGTATACACGGCAACTGACCTATCCGGCAACCAG       GCCAGCTGCATTTTCCATATCAAGGTTATTGATGCAGAACCACCTGTCATAGACTGGTGCAGATCTCC       ACCTCCCGTCCAGGTCTCGGAGAAGGTACATGCCGCAAGCTGGGATGAGCCTCAGTTCTCAGACAACT       CAGGTGCTGAATTGGTCATTACCAGAAGTCATACACAAGGAGACCTTTTCCCTCAAGGGGAGACTATA       GTACAGTATACAGCCACTGACCCCTCAGGCAATAACAGGACATGTGATATCCATATTGTCATAAAAGG       TTCTCCCTGTGAAATTCCATTCACACCTGTAAATGGGGATTTTATATGCACTCCAGATAATACTGGAG       TCAACTGTACATTAACTTGCTTGGAGGGCTATGATTTCACAGAAGGGTCTACTGACAAGTATTATTGT       GCTTATGAAGATGGCGTCTGGAAACCAACATATACCACTGAATGGCCAGACTGTGCCAGTAAGCGTTT       TGCAAACCACGGGTTCAAGTCCTTTGAGATGTTCTACAAAGCAGCTCGTTGTGATGACACAGATCTGA       TGAAGAAGTTTTCTGAAGCATTTGAGACGACCCTGGGAAAAATGGTCCCATCATTTTGTAGTGATGCA       GAGGACATTGACTGCAGACTGGAGGAGAACCTGACCAAAAAATATTGCCTAGAATATAATTATGACTA       TGAAAATGGCTTTGCAATTGGTCCAGGTCGCTGGGGTGCAGCTAATAGGCTGGATTACTCTTACGATG       ACTTCCTGGACACTGTGCAAGAAACAGCCACAAGCATCGGCAATGCCAAGTCCTCACGGATTAAAAGA       AGTGCCCCATTATCTGACTATAAAATTAAGTTAATTTTTAACATCACAGCTAGTGTGCCATTACCCGA       TGAAAGAAATGATACCCTTGAATGGGAAAATCAGCAACGACTCCTTCAGACATTGGAAACTATCACAA       ATAAACTGAAAAGGACTCTCAACAAAGACCCCATGTATTCCTTTCAGCTTGCATCAGAAATACTTATA       GCCGACAGCAATTCATTAGAAACAAAAAAGGCTTCCCCCTTCTGCAGACCAGGCTCAGTGCTGAGAGG       GCGTATGTGTGTCAATTGCCCTTTGGGAACCTATTATAATCTGGAACATTTCACCTGTGAAAGCTGCC       GGATCGGATCCTATCAAGATGAAGAAGGGCAACTTGAGTGCAAGCTTTGCCCCTCTGGGATGTACACG       GAATATATCCATTCAAGAAACATCTCTGATTGTAAAGCTCAGTGTAAACAAGGCACCTACTCATACAG       TGGACTTGAGACTTGTGAATCGTGTCCACTGGGCACTTATCAGCCAAAATTTGGTTCCCGGAGCTGCC       TCTCGTGTCCAGAAAACACCTCAACTGTGAAAAGAGGAGCCGTGAACATTTCTGCATGTGGAGTTCCT       TGTCCAGAAGGAAAATTCTCGCGTTCTGGGTTAATGCCCTGTCACCCATGTCCTCGTGACTATTACCA       ACCTAATGCAGGGAAGGCCTTCTGCCTGGCCTGTCCCTTTTATGGAACTACCCCATTCGCTGGTTCCA       GATCCATCACAGAATGTTCAAGTTTTAGTTCAACTTTCTCAGCGGCAGAGGAAAGTGTGGTGCCCCCT       GCCTCTCTTGGACATATTAAAAAGAGGCATGAAATCAGCAGTCAGGCAAGTCATGAATGCTTCTTTAA       CCCTTGCCACAATAGTGGAACCTGCCAGCAACTTGGGCGTGGTTATGTTTGTCTCTGTCCACTTGGAT       ATACAGGTTTAAGTGTGAAAACAGACATCGATGAGTGCAGCCCACTGCCTTGCCTCAACAATGGAGTT       TGTAAAGACCTAGTTGGGGAATTCATTTGTGAGTGCCCATCAGGTTACACAGGTAAGCACTGTGAATT       GAACATCAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTCAT       ACAGTTGTAAATGTCAGCCAGGATTTTCAGGCAAAAGGTGTGAAACAGGTATGTATCAACTCAGTGTT       ATTAATAACCTTAATAATGCAGTCTGTGAAGACCAGGTTGGGGGATTCTTGTGCAAATGCCCACCTGG       ATTTTTGGGTACCCGATGTGGAAAGAACGTCGATGAGTGTCTCAGTCAGCCATGCAAAAATGGAGCTA       CCTGTAAAGACGGTGCCAATAGCTTCAGGTGCCTGTGTGCAGCTGGCTTCACAGGATCACACTGTGAA       TTGAACATCAATGAATGTCAGTCTAATCCATGTAGAAATCAGGCCACCTGTGTGGATGAATTAAATTC       ATACAGTTGTAAATGTCAGCCAGGATTTTCAGGCAAAAGGTGTGAAACAGAACAGTCTACAGGCTTTA       ACCTGGATTTTGAAGTTTCTGGCATCTATGGATATGTCATGCTAGATGGCATGCTCCCATCTCTCCAT       GCTCTAACCTGTACCTTCTGGATGAAATCCTCTGACGACATGAACTATGGAACACCAATCTCCTATGC       AGTTGATAACGGCAGCGACAATACCTTGCTCCTGACTGATTATAACGGGTGGGTTCTTTATGTGAATG       GCAGGGAAAAGATAACAAACTGTCCCTCGGTGAATGATGGCAGATGGCATCATATTGCAATCACTTCG       ACAAGTACTGGTGGAGCCTGGAGGGTCTATATAAATGGGGAATTATCTGACGGTGGTACTGGCCTCTC       CATTGGCAAAGCCATACCTGGTGGCGGTGCATTAGTTCTTGGGCAAGAGCAAGACAAAAAAGGAGAGG       GGTTCAACCCGGCTGAGTCTTTTGTGGGCTCCATAAGCCAGCTCAACCTCTGGGACTATGTCCTGTCT       CCACAGCAGGTGAAGTCACTGGCTACCTCCTGCCCAGAGGAACTCAGTAAAGGAAACGTGTTAGCATG       GCCTGATTTCTTGTCAGGAATTGTGGGGAAAGTGAAGATCGATTCTAAGAGCATATTTTGTTCTGATT       GCCCACGCTTGGGAGGGTCAGTGCCTCATCTGAGAACTGCATCTGAAGATTTAAAACCAGGTTCCAAA       GTCAATCTGTTCTGTGAACCAGGCTTCCAGCTGGTCGGGAACCCTGTGCAGTACTGTCTGAATCAAGG       ACAGTGGACACAACCACTCCCCCACTGTGAACGCATTCGCTGTGGGGTGCCACCTCCTTTGGAGAATG       GCTTCCATTCAGCCGATGACTTCTATGCTGGCAGCACAGTAACCTACCAGTGCAACAATGGCTACTAT       CTATTGGGTGACTCAAGGATGTTCTGTACAGATAATGGGAGCTGGGACGGCGTTTCACCATCCTGCTT       AGATGTCGATGAGTGTGCAGTTGGATCAGATTGTAGTGAGCATGCTTCTTGCCTGAACGTAGATGGAT       CCTACATATGTTCATGTGTCCCACCGTACACAGGAGATGGGAAAAACTGTGCAGAACCTATAAAATGT       AAGGCTCCAGGAAATCCGGAAAATGGCCACTCCTCAGGTGAGATTTATACAGTAGGTGCCGAAGTCAC       ATTTTCGTGTCAGGAAGGATACCAGTTGATGGGAGTAACCAAAATCACATGTTTGGAGTCTGGAGAAT       GGAATCATCTAATACCATATTGTAAAGCTGTTTCATGTGGTAAACCGGCTATTCCAGAAAATGGTTGC       ATTGAGGAGTTAGCATTTACTTTTGGCAGCAAAGTGACATATAGGTGTAATAAAGGATATACTCTGGC       CGGTGATAAAGAATCATCCTGTCTTGCTAACAGTTCTTGGAGTCATTCCCCTCCTGTGTGTGAACCAG       TGAAGTGTTCTAGTCCGGAAAATATAAATAATGGAAAATATATTTTGAGTGGGCTTACCTACCTTTCT       ACTGCATCATATTCATGCGATACAGGATACAGCTTACAGGGCCCTTCCATTATTGAATGCACGGCTTC       TGGCATCTGGGACAGAGCGCCACCTGCCTGTCACCTCGTCTTCTGTGGAGAACCACCTGCCATCAAAG       ATGCTGTCATTACGGGGAATAACTTCACTTTCAGGAACACCGTCACTTACACTTGCAAAGAAGGCTAT       ACTCTTGCTGGTCTTGACACCATTGAATGCCTGGCCGACGGCAAGTGGAGTAGAAGTGACCAGCAGTG       CCTGGCTGTCTCCTGTGATGAGCCACCCATTGTGGACCACGCCTCTCCAGAGACTGCCCATCGGCTCT       TTGGAGACATTGCATTCTACTACTGCTCTGATGGTTACAGCCTAGCAGACAATTCCCAGCTTCTCTGC       AATGCCCAGGGCAAGTGGGTACCCCCAGAAGGTCAAGACATGCCCCGTTGTATAGCTCATTTCTGTGA       AAAACCTCCATCGGTTTCCTATAGCATCTTGGAATCTGTGAGCAAAGCAAAATTTGCAGCTGGCTCAG       TTGTGAGCTTTAAATGCATGGAAGGCTTTGTACTGAACACCTCAGCAAAGATTGAATGTATGAGAGGT       GGGCAGTGGAACCCTTCCCCCATGTCCATCCAGTGCATCCCTGTGCGGTGTGGAGAGCCACCAAGCAT       CATGAATGGCTATGCAAGTGGATCAAACTACAGTTTTGGAGCCATGGTGGCTTACAGCTGCAACAAGG       GGTTCTACATCAAAGGGGAAAAGAAGAGCACCTGCGAAGCCACAGGGCAGTGGAGTAGTCCTATACCG       ACGTGCCACCCGGTATCTTGTGGTGAACCACCTAAGGTTGAGAATGGCTTTCTGGAGCATACAACTGG       CAGGATCTTTGAGAGTGAAGTGAGGTATCAGTGTAACCCGGGCTATAAGTCAGTCGGAAGTCCTGTAT       TTGTCTGCCAAGCCAATCGCCACTGGCACAGTGAATCCCCTCTGATGTGTGTTCCTCTCGACTGTGGA       AAACCTCCCCCGATCCAGAATGGCTTCATGAAAGGAGAAAACTTTGAAGTAGGGTCCAAGGTTCAGTT       TTTCTGTAATGAGGGTTATGAGCTTGTTGGTGACAGTTCTTGGACATGTCAGAAATCTGGCAAATGGA       ATAAGAAGTCAAATCCAAAGTGCATGCCTGCCAAGTGCCCAGAGCCGCCCCTCTTGGAAAACCAGCTA       GTATTAAAGGAGTTGACCACCGAGGTAGGAGTTGTGACATTTTCCTGTAAAGAAGGGCATGTCCTGCA       AGGCCCCTCTGTCCTGAAATGCTTGCCATCCCAGCAATGGAATGACTCTTTCCCTGTTTGTAAGATTG       TTCTTTGTACCCCACCTCCCCTAATTTCCTTTGGTGTCCCCATTCCTTCTTCTGCTCTTCATTTTGGA       AGTACTGTCAAGTATTCTTGTGTAGGTGGGTTTTTCCTAAGAGGAAATTCTACCACCCTCTGCCAACC       TGATGGCACCTGGAGCTCTCCACTGCCAGAATGTGTTCCAGTAGAATGTCCCCAACCTGAGGAAATCC       CCAATGGAATCATTGATGTGCAAGGCCTTGCCTATCTCAGCACAGCTCTCTATACCTGCAAGCCAGGC       TTTGAATTGGTGGGAAATACTACCACCCTTTGTGGAGAAAATGGTCACTGGCTTGGAGGAAAACCAAC       ATGTAAAGCCATTGAGTGCCTGAAACCCAAGGAGATTTTGAATGGCAAATTCTCTTACACGGACCTAC       ACTATGGACAGACCGTTACCTACTCTTGCAACCGAGGCTTTCGGCTCGAAGGTCCCAGTGCCTTGACC       TGTTTAGAGACAGGTGATTGGGATGTAGATGCCCCATCTTGCAATGCCATCCACTGTGATTCCCCACA       ACCCATTGAAAATGGTTTTGTAGAAGGTGCAGATTACAGCTATGGTGCCATAATCATCTACAGTTGCT       TCCCTGGGTTTCAGGTGGCTGGTCATGCCATGCAGACCTGTGAAGAGTCAGGATGGTCAAGTTCCATC       CCAACATGTATGCCAATAGACTGTGGCCTCCCTCCTCATATAGATTTTGGAGACTGTACTAAACTCAA       AGATGACCAGGGATATTTTGAGCAAGAAGACGACATGATGGAAGTTCCATATGTGACTCCTCACCCTC       CTTATCATTTGGGAGCAGTGGCTAAAACCTGGGAAAATACAAAGGAGTCTCCTGCTACACATTCATCA       AACTTTCTGTATGGTACCATGGTTTCATACACCTGTAATCCAGGATATGAACTTCTGGGGAACCCTGT       GCTGATCTGCCAGGAAGATGGAACTTGGAATGGCAGTGCACCATCCTGCATTTCAATTGAATGTGACT       TGCCTACTGCTCCTGAAAATGGCTTTTTGCGTTTTACAGAGACTAGCATGGGAAGTGCTGTGCAGTAT       AGCTGTAAACCTGGACACATTCTAGCAGGCTCTGACTTAAGGCTTTGTCTAGAGAATAGAAAGTGGAG       TGGTGCCTCCCCACGCTGTGAAGCCATTTCATGCAAAAAGCCAAATCCAGTCATGAATGGATCCATCA       AAGGAAGCAACTACACATACCTGAGCACGTTGTACTATGAGTGTGACCCCGGATATGTGCTGAATGGC       ACTGAGAGGAGAACATGCCAGGATGACAAAAACTGGGATGAGGATGAGCCCATTTGCATTCCTGTGGA       CTGCAGTTCACCCCCAGTCTCAGCCAATGGCCAGGTGAGAGGAGACGAGTACACATTCCAAAAAGAGA       TTGAATACACTTGCAATGAAGGGTTCTTGCTTGAGGGAGCCAGGAGTCGGGTTTGTCTTGCCAATGGA       AGTTGGAGTGGAGCCACTCCCGACTGTGTGCCTGTCAGATGTGCCACCCCGCCACAACTGGCCAATGG       GGTGACGGAAGGCCTGGACTATGGCTTCATGAAGGAAGTAACATTCCACTGTCACGAGGGCTACATCT       TGCACGGTGCTCCAAAACTCACCTGTCAGTCAGATGGCAACTGGGATGCAGAGATTCCTCTCTGTAAA       CCAGTCAACTGTGGACCTCCTGAAGATCTTGCCCATGGTTTCCCTAATGGTTTTTCCTTTATTCATGG       GGGCCATATACAGTATCAGTGCTTTCCTGGTTATAAGCTCCATGGAAATTCATCAAGAAGGTGCCTCT       CCAATGGCTCCTGGAGTGGCAGCTCACCTTCCTGCCTGCCTTGCAGATGTTCCACACCAGTAATTGAA       TATGGAACTGTCAATGGGACAGATTTTGACTGTGGAAAGGCAGCCCGGATTCAGTGCTTCAAAGGCTT       CAAGCTCCTAGGACTTTCTGAAATCACCTGTGAAGCCGATGGCCAGTGGAGCTCTGGGTTCCCCCACT       GTGAACACACTTCTTGTGGTTCTCTTCCAATGATACCAAATGCGTTCATCAGTGAGACCAGCTCTTGG       AAGGAAAATGTGATAACTTACAGCTGCAGGTCTGGATATGTCATACAAGGCAGTTCAGATCTGATTTG       TACAGAGAAAGGGGTATGGAGCCAGCCTTATCCAGTCTGTGAGCCCTTGTCCTGTGGGTCCCCACCGT       CTGTCGCCAATGCAGTGGCAACTGGAGAGGCACACACCTATGAAAGTGAAGTGAAACTCAGATGTCTG       GAAGGTTATACGATGGATACAGATACAGATACATTCACCTGTCAGAAAGATGGTCGCTGGTTCCCTGA       ACGATTTCAGTGTGAATAGGCAAGTTTCTGTGTCATGTGCAGAAGGGTATACCTTTGAGGGAGTTAAC       ATATCAGTATGTCAGCTTGATGGAACCTGGGAGCCACCATTCTCCGATGAATCTTGCAGTCCAGTTTC       TTGTGGGAAACCTGAAAGTCCAGAACATGGATTTGTGGTTGGCAGTAAATACACCTTTGAAAGCACAA       TTATTTATCAGTGTGAGCCTGGCTATGAACTAGAGGGGAACAGGGAACGTGTCTGCCAGGAGAACAGA       CAGTGGAGTGGAGGGGTGGCAATATGCAAAGAGACCAGGTGTGAAACTCCACTTGAATTTCTCAATGG       GAAAGCTGACATTGAAAACAGGACGACTGGACCCAACGTGGTATATTCCTGCAACAGAGGCTACAGTC       TTGAAGGGCCATCTGAGGCACACTGCACAGALAATGGAACCTGGAGCCACCCAGTCCCTCTCTGCAAA       CCAAATCCATGCCCTGTTCCTTTTGTGATTCCCGAGAATGCTCTGCTGTCTGAAAAGGAGTTTTATGT       TGATCAGAATGTGTCCATCAAATGTAGGGAAGGTTTTCTGCTGCAGGGCCACGGCATCATTACCTGCA       ACCCCGACGAGACGTGGACACAGACAAGCGCCAAATGTGAAAAAATCTCATGTGGTCCACCAGCTCAC       GTAGAAAATGCAATTGCTCGAGGCGTACATTATCAATATGGAGACATGATCACCTACTCATGTTACAG       TGGATACATGTTGGAGGGTTTCCTGAGGAGTGTTTGTTTAGAAAATGGAACATGGACATCACCTCCTA       TTTGCAGAGCTGTCTGTCGATTTCCATGTCAGAATGGGGGCATCTGCCAACGCCCAAATGCTTGTTCC       TGTCCAGAGGGCTGGATGGGGCGCCTCTGTGAAGAACCAATCTGCATTCTTCCCTGTCTGAACGGAGG       TCGCTGTGTGGCCCCTTACCAGTGTGACTGCCCGCCTGGCTGGACGGGGTCTCGCTGTCATACAGCTG       TTTGCCAGTCTCCCTGCTTAAATGGTGGAAAATGTGTAAGACCAAACCGATGTCACTGTCTTTCTTCT       TGGATGGGACATAACTGTTCCAGGAAAAGGAGGACTGGGTTTTAACCACTGCACGACCATCTGGCTCT       CCCAAAAGCAGGATCATCTCTCCTCGGTAGTGCCTGGGCATCCTGGAACTTATGCAAAGAAAGTCCAA       CATGGTGCTGGGTCTTGTTTAGTAAACTTGTTACTTGGGGTTACTTTTTTTATTTTGTGATATATTTT       GTTATTCCTTGTGACATACTTTCTTACATGTTTCCATTTTTAAATATGCCTGTATTTTCTATATAAAA       ATTATATTAAATAGATGCTGCTCTACCCTCACALAATGTACATATTCTGCTGTCTATTGGGAAAGTTC       CTGGTACACATTTTTATTCAGTTACTTAAAATGATTTTTCCATTAAAGTATATTTTGCTACTAAATAA       AAAAAA                                                 NOV8o, SNP13382480 of   SEQ ID NO: 206       MW at 390042.6kD                                 CG50646-04, Protein Sequence   SNP Pos: 3558   3570 aa   SNP Change: Thr to Met                             MRRICAACWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRVERLGQAFR           VRLLRELSERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTATRVAIVTFSSKNYVVPRVDY       ISTRRARQHKCALLLQEIPAlSYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPI       AASLRDSGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALVALCHMLFVDLPSGSFIQDD       MVHCSYLCDEGKDCCDRMGSCKCGKHTGHFECICEKGYNGKGLQYDCTVCPSGTYKPEGSPGGISSCI       PCPDENHTSPPGSTSPEDCVCREGYFASGQTCEVVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPG       FDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYPLEGSDK       LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCT       TSGWNNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEKVSVHVHPAFTPPY       LFPIGDVAIVYTATDLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWDEPQFSDNSGA       ELVITRSHTQGDLFPQGETIVQYTATDPSGNNRTCDIHIVIKGSPCEIPFTPVNGDFICTPDNTGVNC       TLTCLEGYDFTEGSTDKYYCAYEDGVWKPTYTTEWPDCASKRFANHGFKSFEMFYKAARCDDTDLMKK       FSEAFETTLGKMVPSFCSDAEDIDCRLEENLTKKYCLEYNYDYENGFAIGPGGWGAANRLDYSFDDFL       DTVQETATSIGNAKSSRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKL       KRTLNKDPMYSFQLASEILIADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRIG       SYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSC       PENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSI       TECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQASHECFFNPCHNSGTCQQLGRGYVCLCPLGYTG       LKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGKHCELNINECQSNPCRNQATCVDELNSYSC       KCQPGFSGKRCETGMYQLSVINNLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCK       DGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLD       FEVSGIYGYVMLDGMLPSLHAITCTFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGRE       KITNCPSVNDGRWHHIAITWTSTGGAWRVYINGELSDGGTGLSIGKAIPGGGALVLGQEQDKKGEGFN       PAESFVGSISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPR       LGGSVPHLRTASEDLKPGSKVNLFCEPGFQLVGNPVQYCLNQGQWTQPLPHCERIRCGVPPPLENGFH       SADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYI       CSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNH       LIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKC       SSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAV       ITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGD       IAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVS       FKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFY       IKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVC       QANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKK       SNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLC       TPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNG       IIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYG       QTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPG       FQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYH       LGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPT       APENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGS       NYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEY       TCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHG       APKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNG       SWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEH       TSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVA       NAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDF       SVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIY       QCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYSCNRGYSLEG       PSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPD       ETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICR       AVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQ       SPCLNGGKCVRPNRCHCLSSWMGHNCSRKRRTGF                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 8B.  
               TABLE 8B                       Comparison of the NOV8 protein sequences.                                        NOV8a MRRICAACWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRV           NOV8b --------------RPWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRV       NOV8c --------------RPWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRV       NOV8d --------------RPWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRV       NOV8e --------------RPWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRV       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h --------------MAGAPPPASLPPCSLISDCCASNQRDSVGVGPSEPGVGYSLVVRRF       NOV8i MRRICAACWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSRV               NOV8a ERLGQAFR--VRLLRELSERLELVFLVDDSSS----------------------------       NOV8b ERLGQAFRRRVRLLRELSERLELVFLVDDSSS----------------------------       NOV8c ERLGQAFRRRVRLLRELSERLELVFLVDDSSS----------------------------       NOV8d ERLGQAFRRRVRLLRELSERLELVFLVDDSSS----------------------------       NOV8e ERLGQAFRRRVRLLRELSERLELVFLVDDSSS----------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h LSRSEKRNIRVGVTRFSSYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPET       NOV8i ERLGQAFR--VRLLRELSERLELVFLVDDSSS----------------------------               NOV8a ----------------------------VGEVNFRSELMFVRKLLSDFPVVPTATRVAIV       NOV8b ----------------------------VGEVNFRSELMFVRKLLSDFPVVPTATRVAIV       NOV8c ----------------------------VGEVNFRSELMFVRKLLSDFPVVPTATRVAIV       NOV8d ----------------------------VGEVNFRSELMFVRKLLSDFPVVPTATRVAIV       NOV8e ----------------------------VGEVNFRSELMFVRKLLSDFPVVPTATRVAIV       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h AHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSIL       NOV8i ----------------------------VGEVNFRSELMFVRKLLSDFPVVPTATRVAIV               NOV8a TFSSKN------------------------------YVVPRVDYISTRRARQHKCALLLQ       NOV8b TFSSKN------------------------------YVVPRVDYISTPRARQHKCALLLQ       NOV8c TFSSKN------------------------------YVVPRVDYISTRPARQHKCALLLQ       NOV8d TFSSKN------------------------------YVVPRVDYISTRRARQHKCALLLQ       NOV8e TFSSKN------------------------------YVVPRADYISTRRARQHKCALLLQ       NOV8f ------------------------------------------MSIQCIPVRCGEPPSINN       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i TFSSKN------------------------------YVVPRVDYISTRRARQHKCALLLQ               NOV8a EIPAISYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPIAASLRDSG       NOV8b EIPAISYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPIAASLRDSG       NOV8c EIPAISYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPIAASLRDSG       NOV8d EIPAISYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPIAASLRDSG       NOV8e EIPAISYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPIAASLRDSG       NOV8f GYASGSNYSFGAMVAYSCNKGFYIKGEKYSTCEATGQWSSPIPTCHPVSCGEPPKVENGF       NOV8g --------------------------------------------MLSSVIQIALTCFLPV       Nov8h GYASGSNYSFGAMVAYSCNKGFYIKGEKYSTCEATGQWSSPIPTCHPVSCGEPPKVENGF       NOV8i EIPAISYRGGGTYTKGAFQQAAQILLHARENSTKVVFLITDGYSNGGDPRPIAASLRDSG               NOV8a VEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALVALCHMLFVDLPSGSFIQDD       NOV8b VEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALAR--RALHEDLPSGSFIQDD       NOV8c VEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALAR--RALHEDLPSGSFIQDD       NOV8d VEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALAR--RALHEDLPSGSFIQDD       NOV8e VEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALAR--RALHEDLPSGSFIQDD       NOV8f LEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESP-LMCVPLDCGKPPPIQNG       NOV8g AQHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESP-LMCVPLDCGKPPPIQNG       NOV8h LEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESP-LMCVPLDCGKPPPIQNG       N0V8i VEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALAR--RALHEDLPSGSFIQDD               NOV8a MVHCSYLCDEGKDCCDRMGSCKCGKHTGHFECICEKGYNGKG----LQYDCTVCPSGTYK       NOV8b MVHCSYLCDEGKDCCDRMGSCKCGTHTGHFECICEKGYNGKG----LQYECTACPSGTYK       NOV8c MVHCSYLCDEGKDCCDRMGSCKCGTHTDRFECICEKGYYGKG----LQYECTACPSGTYK       NOV8d MVHCSYLCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKG----LQYECTACPSGTYK       NOV8e MVHCSYLCDEGKDCCDRNGSCKCGTHTGHFECICEKGYYGKG----LQYECTACPSGTYK       NOV8f FMKGENFEVGSKVQFFCNEGY-ELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQ       NOV8g FMKGENFEVGSKVQFFCNEGY-ELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQ       NOV8h FMKGENFEVGSKGQFFCNEGLXSFVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQ       NOV8i MVHCSYLCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKG----LQYECTACPSGTYK               NOV8a PEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCEVVHCPALKPPENGYF       NOV8b PEASPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYPASGQTCELVHCPALKPPENGYF       NOV8c PEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPAWKPPENGYF       NOV8d PEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYF       NOV8e PEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYF       NOV8f LVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVP       NOV8g LVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVP       NOV8h LVLKELTTEVGVVTFSCKERHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVP       NOV8i PEASPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYF               NOV8a IQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHI       NOVBb IQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHI       NOV8c IQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHI       NOV8d IQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHI       NOV8e IQNTCNMHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHI       NOV8f IP-SSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGII       NOV8g IP-SSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEETPNGII       NOV8h IP-SSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGII       NOV8i IQNTCNNEFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHI               NOV8a SCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVII       NOV8b SCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVII       NOV8c SCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDIII       NOV8d SCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVII       NOV8e SCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDIII       NOV8f DVQG--LAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKP---T--CKAIECLKPKEI       NOV8g DVQG--LAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKP---T--CKAIECLKPKEI       NOV8h DVQG--LAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKP---T--CKAIECLKPKEI       NOV8i SCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVII               NOV8a SPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINC       NOV8b SPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINC       NOV8c SPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINC       NOV8d SPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINC       NOV8e SPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINC       NOV8f LNGKFSYTDLHYGQTVTYSCNRGFRLEGS-QCLDLFRDR---------------------       NOV8g LNGKFSYTDLHYGQTVTYSCNRGFRLEGS-QCLDLFRDR---------------------       NOV8h LNGKFSYTDLHYGQTVTYSCNRGFRLEGP-SALTCLETGDWDVDAPSCNAIHCDSPQPIE       NOV8i SPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINC               NOV8a PKDIEAKTLEQ-------------------------------------------------       NOV8b PKDIEAKTLEQ-------------------------------------------------       NOV8c PKDIEAKTLEQ-------------------------------------------------       NOV8d PKDIEAKTLEQ-------------------------------------------------       NOV8e PKDIEAKTLEQ-------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h NGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGD       NOV8i PKDIEAKTLEQ-------------------------------------------------               NOV8a ------------------------------------------------------------       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h CTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSY       NOV8i ------------------------------------------------------------               NOV8a --------------------------QDSANVTWQIPTAKDN-----SGEKVSVHVHPAF       NOV8b --------------------------QDSANVTWQIPTAKDN-----SGEKVSVHVHPAF       NOV8c --------------------------QDSANVTWQIPTAKDN-----SGEKVSVHVHPAF       NOV8d --------------------------QDSANVTWQIPTAKDN-----SGEKVSVHVHPAF       NOV8e --------------------------QDSANVTWQIPTAKDN-----SGEKVSVHVHPAF       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h TCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSC       NOV8i --------------------------QDSANVTWQIPTAKDN-----SGEKVSVHVHPAF               NOV8a TPPYLFPIGDVAIVYTATDLSGN-------------------------------------       NOV8b TPPYLFPIGDVAIVYTATDLSGN-------------------------------------       NOV8c TPPYLFPIGDVAIVYTATDLSGN-------------------------------------       NOV8d TPPYLFPIGDVAIVYTATDLSGN-------------------------------------       NOV8e TPPYLFPIGDVAIVYTATDLSGN-------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h KPGHILAGSDLRLCLENRXWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDP       NOV8i TPPYLFPIGDVAIVYTATDLSGN-------------------------------------               NOV8a --------QASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWD-------------       NOV8b --------QASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWD-------------       NOV8c --------QASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWD-------------       NOV8d --------QASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWD-------------       NOV8e --------QASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWD-------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOv8h GYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGF       NOV8i --------QASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHAASWD-------------               NOV8a ------------------------------------------------------------       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h LLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYIL       NOV8i ------------------------------------------------------------               NOV8a ------------------------------------------------------------       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h HGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHG       NOV8i ------------------------------------------------------------               NOV8a ------------------------------------------------------------       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h NSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSE       NOV8i ------------------------------------------------------------               NOV8a ------------------------------------------------------------       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLI       NOV8i ------------------------------------------------------------               NOV8a ------------------------------------------------------------       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h CTEKGVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTC       NOV8i ------------------------------------------------------------               NOV8a ------------------------------------------------------------       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h QKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQL       NOV8i ------------------------------------------------------------               NOV8a ----EPQFSDNSGAELVITRSHTQGDLFPQGE---------------TIVQYTATDPSGN       NOV8b ----EPQFSDNSGAELVITRSHTQGDLFPQGE---------------TIVQYTATDPSGN       NOV8c ----EPQFSDNSGAELVITRSHTQGDLFPQGE---------------TIVQYTATDPSGN       NOV8d ----EPQFSDNSGAELVITRSHTQGDLFPQGE---------------TIVQYTATDPSGN       NOV8e ----EPQFSDNSGAELVITRSHTQGELFPQGE---------------TIVQYTATDPSGN       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h DGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELENLAVNPSGP       NOV8i ----EPQFSDNSGAELVITRSHTQGDLFPQGE---------------TIVQYTATDPSGN               NOV8a ---------------------------------------NRTCDIHIVIKGSPCEIPFTP       NOV8b ---------------------------------------NRTCDIHIVILE---------       NOV8c ---------------------------------------NRTCDIHIVILE---------       NOV8d ---------------------------------------NRTCDIHIVILE---------       NOV8e ---------------------------------------NRTCDIHIVILE---------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h GLFLVDRTLSCRSELARGPIQTLFAWVSAAEGAEQRTLVNRKCCCLIIPLEVLSQRNTRP       NOV8i ---------------------------------------NRICDIHIVMKGSPCEIPFTP               NOV8a VNGDFICTPDNTGVNCTLTCLEGYDFTEGSTDKYYCAYEDGVWKPTYTTEWPDCASKRFA       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h CEVSVRPYWGGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGPNVVYS       NOV8i VNGDFICTPDNTGVNCTLTCLEGYDFTEGSTDKYYCAYEDGVWKPTYTTEWPDCASKRFA               NOV8a NHGFKSFEMFYKAARCDDTDLMKKFSEAFETTLGKMVPSFCSDAEDIDCRLEENLTKKYC       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h CNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQNVSIKC       NOV8i NHGFKSFEMFYKAARCDDSDLMKKFSEAFETTLGKMVPSFCSDAEDIDCRLEENLTKKYC               NOV8a LEYNYDYENGFAIGPGGWGAANRLDYSYDDFLDTVQETATSIGNAKSSRIKRSAPLSDYK       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h REGFLLQGHGIITCNPDETWTQTSAKCERRYTQQPKSLNFQLAAYCSIRMFILRGGVQDG       NOV8i LEYNYDYENGFAIGPGGWGAANRLDYSYDDFLDTVQETATSIGNAKSSRIKRSAPLSDYK               NOV8a IKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKLKRTLNKDPMYSFQLASEILI       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h QLETAVAGASHREEQKQKREKARWYNGPPGSHMGQAELPPPAKGGGPPCGNFSNSSQGFM       NOV8i IKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKLKRTLNKDPMYSFQLASEILI               NOV8a ADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRIGSYQDEEGQLECK       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h NRPLISLRWSPWGSMWPWSPQISRLSPSPAGSEESRQAGLVGFPTAQFTdSAKGQLERFV       NOV8i ADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRIGSYQDEEGQLECK               NOV8a LCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSCPENT       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h KRVPDPMPPDWDETPPQQGSRMRPPHNRGHQTPYTRVFLLASGQCPSGTELPEERAGSHL       NOV8i LCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTVQPKFGSRSCLSCPENT               NOV8a STVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAG       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h CCSAASAGKAQNWAEARIDELKEVGFRKWVIMKFAELKEHVLNQCKDAKNQDKTLQDPLT       NOV8i STVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAG               NOV8a SRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQASHECFFNPCHNSGTCQQLGR       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h RITSLERNVNDLMELKNTTRELHNATTKQGQHSSSGNPENPSKILHEKINPKTHNPQVLQ       NOV8i SRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQASHECFFNPCHNSGTCQQLGR               NOV8a GYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGKHCELNINEC       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h EISCGPPAHVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVC       NOV8i GYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGKHCELNINEC               NOV8a QSNPCRNQATCVDELNSYSCKCQPGFSGKRCETGMYQLSVINNLNNAVCEDQVGGFLCKC       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h RFPCQNGGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCH       Nov8i QSNPCRNQATCVDELNSYSCKCQPGFSGKRCETGMYQLSVINNLNNAVCEDQVGGFLCKC               NOV8a PPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCR       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h TGRPLSWFVFLVAQAHETPEDIEECDLDSEVVAK--------------------------       NOV8i PPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCR               NOV8a NQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVMLDGMLPSLHALTC       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i NQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVMLDGMLPSLHALTC               NOV8a TFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGREKITNCPSVNDGRWHHI       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i TFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGREKITNCPSVNDGRWHHI               NOV8a AITWTSTGGAWRVYINGELSDGGTGLSIGKAIPGGGALVLGQEQDKKGEGFNPAESFVGS       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i AITWTSTGGAWRVYINGELSDGGTGLSIGKAIPGGGALVLGQEQDKKGEGFNPAESFVGS               NOV8a ISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPR       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i ISQLNLWDYVLSPQQVKSIATSCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPR               NOV8a LGGSVPHLRTASEDLKPGSKVNLFCEPGFQLVGNPVQYCLNQGQWTQPLPHCERIRCGVP       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i LGGSVPHLRTASEDLKPGSKVNLFCEPGFQLVGNPVQYCLNQGQWTQPLPHCERIRCGVP               NOV8a PPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSPMFCTDNGSWNGVSPSCLDVDECAVGS       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i PPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGS               NOV8a DCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTF       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i DCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTF               NOV8a SCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFTFGSKVTYRC       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i SCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPATPENGCIEELAFTFGSKVTYRC               NOV8a NKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDT       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i NKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDT               NOV8a GYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGY       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i GYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGY               NOV8a TLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSL       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i TLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSL               NOV8a ADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCM       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i ADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCM               NOV8a EGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCN       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i EGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCN               NOV8a KGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNP       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i KGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNP               NOV8a GYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEG       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i GYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEG               NOV8a YELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSCKEGH       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i YELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSCKEGH               NOV8a VLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFF       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i VLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFF               NOV8a LRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELV       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i LRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELV               NOV8a GNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGP       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i GNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGP               NOV8a SALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAM       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i SALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAM               NOV8a QTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYH       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i QTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYH               NOV8a LGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCI       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i LGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCI               NOV8a SIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAI       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i SIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAI               NOV8a SCKKPNPVNNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDC       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i SCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDC               NOV8a SSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCAT       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i SSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCAT               NOV8a PPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPE       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i PPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPE               NOV8a DLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIE       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i DLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIE               NOV8a YGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNA       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i YGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNA               NOV8a FISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVA       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i FISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVA               NOV8a TGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVH       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i TGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVH               NOV8a GDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVV       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i GDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVV               NOV8a GSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIE       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i GSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIE               NOV8a NRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKE       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i NRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKE               NOV8a FYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENATARGVHYQ       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i FYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQ               NOV8a YGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGGICQRPNACSCPEG       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i YGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGGICQRPNACSCPEG               NOV8a WMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRPNRCH       NOV8b ------------------------------------------------------------       NOV8c ------------------------------------------------------------       NOV8d ------------------------------------------------------------       NOV8e ------------------------------------------------------------       NOV8f ------------------------------------------------------------       NOV8g ------------------------------------------------------------       NOV8h ------------------------------------------------------------       NOV8i WMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRPNRCH               NOV8a CLSSWTGHNCSRKRRTGF       NOV8b ------------------       NOV8c ------------------       NOV8d ------------------       NOV8e ------------------       NOV8f ------------------       NOV8g ------------------       NOV8h ------------------       NOV8i CLSSWTGHNCSRKRRTGF               NOV8a (SEQ ID NO: 178)       NOV8b (SEQ ID NO: 180)       NOV8c (SEQ ID NO: 182)       NOV8d (SEQ ID NO: 184)       NOV8e (SEQ ID NO: 186)       NOV8f (SEQ ID NO: 188)       NOV8g (SEQ ID NO: 190)       NOV8h (SEQ ID NO: 192)       NOV8i (SEQ ID NO: 194)                  
 
      Further analysis of the NOV8a protein yielded the following properties shown in Table 8C.  
               TABLE 8C                       Protein Sequence Properties NOV8a                                        SignalP analysis:   Cleavage site between residues 17 and 18       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 3; pos. chg 2; neg. chg 0           H-region:   length 23; peak value 8.53           PSG score:   4.12                     GvH:   von Heijne&#39;s method for signal seq recognition           GvH score (threshold: −2.1): −2.66           possible cleavage site: between 16 and 17                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 2           Number of TMS(s) for threshold 0.5: 0                             PERIPHERAL   Likelihood = 0.58 (at 253)                         ALOM score: −0.16 (number of TMSs: 0)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 6           Charge difference: −2.0 C(1.0)-N(3.0)           N &gt;= C: N-terminal side will be inside       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:    4   Hyd Moment(75):   11.27           Hyd Moment(95):   11.90   G content:   2           D/E content:    1   S/T content:   5                         Score: 0.60       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-10 motif at 37 SRN FS                 NUCDISC: discrimination of nuclear localization signals                         pat4: KKRH (3) at 1183           pat4: RKRR (5) at 3564           pat7: none           bipartite: none           content of basic residues: 8.0%           NLS Score: 0.03       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: RRIC                 none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: found       RLGGSVPHL at 1632       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 76.7       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         65.2%: nuclear           21.7%: mitochondrial            8.7%: cytoplasmic            4.3%: vacuolar                 &gt;&gt; prediction for CG50646-04 is nuc (k = 23)                  
 
      A search of the NOV8a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 8D.  
               TABLE 8D                          Geneseq Results for NOV8a                                         NOV8a                       Residues/   Identities/       Geneseq   Protein/Organism/Length   Match   Similarities for the   Expect       Identifier   [Patent #, Date]   Residues   Matched Region   Value               ABJ10589   Human novel protein NOV2a SEQ ID   1 . . . 3570    3570/3570 (100%)   0.0           NO: 6 -  Homo sapiens , 3570 aa.   1 . . . 3570    3570/3570 (100%)           [WO200259315-A2, 01-AUG-2002]       ABJ10590   Human novel protein NOV2b SEQ ID   1 . . . 3570   3551/3570 (99%)   0.0           NO: 8 -  Homo sapiens , 3568 aa.   1 . . . 3568   3555/3570 (99%)           [WO200259315-A2, 01-AUG-2002]       AAE20146   Human C3b/C4b complement   3 . . . 3570   3502/3570 (98%)   0.0           receptor-like protein -  Homo sapiens ,   4 . . . 3571   3519/3570 (98%)           3571 aa. [WO200210388-A2, 07-           FEB-2002]       AAE20147   Mouse C3b/C4b complement   3 . . . 3569   2886/3570 (80%)   0.0           receptor-like protein -  Mus musculus ,   31 . . . 3593    3174/3570 (88%)           3594 aa. [WO200210388-A2, 07-           FEB-2002]       AAM93954   Human polypeptide, SEQ ID NO:   2074 . . . 3570     1485/1497 (99%)   0.0           4153 -  Homo sapiens , 1497 aa.   1 . . . 1497   1487/1497 (99%)           [EP1130094-A2, 05-SEP-2001]                  
 
      In a BLAST search of public sequence databases, the NOV8a protein was found to have homology to the proteins shown in the BLASTP data in Table 8E.  
               TABLE 8E                          Public BLASTP Results for NOV8a                                         NOV8a               Protein       Residues/   Identities/       Accession       Match   Similarities for the   Expect       Number   Protein/Organism/Length   Residues   Matched Portion   Value                                             Q9ES77   Polydom protein precursor -  Mus     3 . . . 3569   2894/3570   (81%)   0.0             musculus  (Mouse), 3567 aa.   4 . . . 3566   3180/3570   (89%)       Q8NBT9   Hypothetical protein FLJ90754 -   2074 . . . 3570     1485/1497   (99%)   0.0             Homo sapiens  (Human), 1497 aa.   1 . . . 1487   1487/1497   (99%)       Q96JU7   Hypothetical protein FLJ14964 -   231 . . . 1546    1255/1316   (95%)   0.0             Homo sapiens  (Human), 1316 aa.   1 . . . 1314   1267/1316   (95%)       Q8C720   Polydomain protein -  Mus     3 . . . 845    694/846   (82%)   0.0             musculus  (Mouse), 848 aa   4 . . . 846    748/846   (88%)           (fragment).       Q922H0   Polydomain protein -  Mus     2902 . . . 3569     534/668   (79%)   0.0             musculus  (Mouse), 669 aa   2 . . . 668    594/668   (87%)           (fragment).                  
 
      PFam analysis predicts that the NOV8a protein contains the domains shown in the Table 8F.  
               TABLE 8F                          Domain Analysis of NOV8a                                     Identities/                   Similarities       Pfam Domain   NOV8a Match Region   for the Matched Region   Expect Value                                         vwa    80 . . . 256   57/200   (28%)   5.1e−37               128/200   (64%)       Metallothio_PEC   269 . . . 324   22/80   (28%)   0.15               27/80   (34%)       sushi   377 . . . 432   18/64   (28%)     1e−06               39/64   (61%)       sushi   437 . . . 492   21/64   (33%)   4.6e−14               48/64   (75%)       sushi   497 . . . 558   12/68   (18%)   0.17               39/68   (57%)       HYR   560 . . . 641   29/86   (34%)   6.1e−16               57/86   (66%)       HYR   642 . . . 721   27/86   (31%)   3.4e−16               54/86   (63%)       TNFR_c6   1017 . . . 1055   14/48   (29%)   0.74               34/48   (71%)       EGF   1196 . . . 1227   18/47   (38%)   3.9e−07               24/47   (51%)       EGF   1234 . . . 1265   18/47   (38%)   1.2e−10               27/47   (57%)       EGF   1272 . . . 1303   17/47   (36%)   6.9e−10               28/47   (60%)       EGF   1348 . . . 1379   13/47   (28%)   1.3e−08               26/47   (55%)       EGF   1386 . . . 1417   17/47   (36%)   6.9e−10               28/47   (60%)       pentaxin   1430 . . . 1622   57/209   (27%)     5e−14               99/209   (47%)       sushi   1630 . . . 1684   18/64   (28%)   2.3e−10               42/64   (66%)       sushi   1689 . . . 1742   25/63   (40%)   3.3e−17               43/63   (68%)       EGF   1748 . . . 1782   14/47   (30%)   1.8e−05               26/47   (55%)       sushi   1788 . . . 1841   24/63   (38%)     2e−15               43/63   (68%)       sushi   1846 . . . 1899   20/63   (32%)   4.2e−14               45/63   (71%)       sushi   1904 . . . 1957   22/63   (35%)   8.5e−14               42/63   (67%)       sushi   1962 . . . 2015   22/63   (35%)   1.9e−13               39/63   (62%)       sushi   2020 . . . 2077   19/64   (30%)   5.4e−07               42/64   (66%)       sushi   2082 . . . 2140   17/65   (26%)   2.3e−08               39/65   (60%)       sushi   2145 . . . 2198   24/63   (38%)   3.8e−18               46/63   (73%)       sushi   2203 . . . 2258   19/64   (30%)   3.3e−10               45/64   (70%)       sushi   2263 . . . 2317   26/63   (41%)   9.4e−17               46/63   (73%)       sushi   2322 . . . 2375   21/63   (33%)   3.2e−08               41/63   (65%)       sushi   2380 . . . 2434   24/63   (38%)   1.9e−13               43/63   (68%)       sushi   2439 . . . 2492   21/63   (33%)   3.8e−11               42/63   (67%)       sushi   2497 . . . 2550   26/63   (41%)   3.4e−15               43/63   (68%)       sushi   2555 . . . 2607   22/63   (35%)   1.1e−12               38/63   (60%)       sushi   2659 . . . 2711   21/65   (32%)   2.9e−10               43/65   (66%)       sushi   2716 . . . 2769   19/63   (30%)   9.6e−10               38/63   (60%)       sushi   2774 . . . 2827   20/63   (32%)   5.2e−14               45/63   (71%)       sushi   2832 . . . 2885   22/63   (35%)   1.1e−14               42/63   (67%)       sushi   2890 . . . 2943   21/63   (33%)   7.6e−12               35/63   (56%)       sushi   2948 . . . 3001   19/63   (30%)   7.6e−13               40/63   (63%)       sushi   3006 . . . 3058   21/62   (34%)   3.8e−08               37/62   (60%)       sushi   3063 . . . 3116   22/63   (35%)   5.7e−11               44/63   (70%)       sushi   3121 . . . 3175   17/64   (27%)   1.1e−10               40/64   (62%)       sushi   3180 . . . 3235   16/62   (26%)   1.2e−05               39/62   (63%)       sushi   3240 . . . 3293   19/63   (30%)   1.2e−12               44/63   (70%)       sushi   3298 . . . 3351   23/63   (37%)   1.6e−10               41/63   (65%)       sushi   3356 . . . 3410   18/64   (28%)   3.6e−09               41/64   (64%)       sushi   3415 . . . 3467   22/63   (35%)   1.5e−12               42/63   (67%)       EGF   3467 . . . 3498   13/47   (28%)    0.0029               22/47   (47%)       EGF   3503 . . . 3530   18/47   (38%)     2e−05               24/47   (51%)       EGF   3535 . . . 3562   13/47   (28%)    0.0034               22/47   (47%)                  
 
     Example 9  
      The NOV9 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 9A.  
               TABLE 9A                       NOV9 Sequence Analysis                                                        NOV9a, CG50736-09   SEQ ID NO: 207   3260 bp               DNA Sequence   ORF Start: ATG at 171   ORF Stop: TGA at 2862                       GGCACGAGCAGGAGCTTCCCAAGAACCCGAAAACTTCCCAGTATTTCTTCCAGTTGCAGGAGCATTTC               GTGAAAGATCTGGTCGGCCCAGGCCCCTTCACTGTTTTTGCACCTTTATCTGCAGCCTTTGATGAGGA           AGCTCGGGTTAAAGACTGGGACAAATACGGTTTA   ATG CCCCAGGTTCTTCGGTACCATGTGGTCGCCT       GCCACCAGCTGCTTCTGGAAAACCTGAAATTGATCTCAAATGCTACTTCCCTCCAAGGAGAGCCAATA       GTCATCTCCGTCTCTCAGAGCACGGTGTATATAAATAATAAGGCTAAGATCATATCCAGTGATATCAT       CAGTACTAATGGGATTGTTCATATCATAGACAAATTGCTATCTCCCAAAAATTTGCTTATCACTCCCA       AAGACAACTCTGGAAGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTT       AGCAACTTAATACAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCT       CTTCTGGCCCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAG       ACAACAAGGACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTG       GATCTTCCCACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGG       CAGGGACATCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTG       ACCTGGGTGTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACC       TTTACTACTTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAG       TAAACCAAAGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCC       GGGAGCGGTGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAG       GCCTGCCCTGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCAC       CGGAGAGTGTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTCG       GGCCTGATTGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGG       CAGTGCCTCTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTG       TACGCCTCCTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATG       AAGGTGACGGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTG       GCCAGATGCTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCA       CAGCTGCACAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTA       AGATGACAGGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGT       GAGCCGGAGCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATG       TGTCGACCTCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATA       AGCTGACCTTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAG       CTCTCCTATGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGC       CTACCCCACAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATAGTGGACTATGGACCTA       GACCCAACAAGAGTGAAATGTGGGATGTCTTCTGCTATCGGATGAAAGATGTGAACTGCACCTGCAAG       GTGGGCTATGTGGGAGATGGCTTCTCATGCAGTGGGAACCTGCTGCAGGTCCTGATGTCCTTCCCCTC       ACTCACAAACTTCCTGACGGAAGTGCTGGCCTATTCCAACAGCTCAGCTCGAGGCCGTGCATTTCTAG       AACACCTGACTGACCTGTCCATCCGCGGCACCCTCTTTGTGCCACAGAACAGTGGGCTGGGGGAGAAT       GAGACCTTGTCTGGGCGGGACATCGAGCACCACCTCGCCAATGTCAGCATGTTTTTCTACAATGACCT       TGTCAATGGCACCACCCTGCAAACGAGGGTGGGAAGCAAGCTGCTCATCACTGCCAGCCAGGACCCAC       TCCAACCGACGGAGACCAGGTTTGTTGATGGAAGAGCCATTCTGCAGTGGGACATCTTTGCCTcCAAT       GGGATCATTCATGTCATTTCCAGGCCTTTAAAAGCACCCCCTGCCCCCGTGACCTTGACCCACACTGG       CTTGGGAGCAGGGATCTTCTTTGCCATCATCCTGGTGACTGGGGCTGTTGCCTTGGCTGCTTACTCCT       ACTTTCGGATAAACCGGAGAACAATCGGCTTCCAGCATTTTGAGTCGGAAGAGGACATTAATGTTGCA       GCTCTTGGCAAGCAGCAGCCTGAGAATATCTCGAACCCCTTGTATGAGAGCACAACCTCAGCTCCCCC       AGAACCTTCCTACGACCCCTTCACGGACTCTGAAGAACGGCAGCTTGAGGGCAATGACCCCTTGAGGA       CACTG TGA   GGGCCTGGACGGGAGATGCCAGCCATCACTCACTGCCACCTGGGCCATCAACTGTGAATT           CTCAGCACCAGTTGCCTTTTAGGAACGTAAAGTCCTTTAAGCACTCAGAAGCCATACCTCATCTCTCT           GGCTGATCTGGGGGTTGTTTCTGTGGGTGAGAGATGTGTTGCTGTGCCCACCCAGTACAGCTTCCTCC           TCTGACCCTTTGGCTCTTCTTCCTTTGTACTCTTCAGCTGGCACCTGCTCCATTCTGCCCTACATGAT           GGGTAACTGTGATCTTTCTTCCCTGTTAGATTGTAAGCCTCCNTCTTTGTATCCCAGCCCCTAGCCCA           GTGCCTGACACAGGAACTGTGCACAATAAGGTTTATGGACAGAAAAAAAAAAAAAAAAAAAAAA                                                   NOV9a, CG50738-09   SEQ ID NO: 208   897 aa   MW at 97584.6kD               Protein Sequence                     MPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVSQSTVYINNKAKIISSDIISTNGIVHIIDK           LLSPKNLLITPKDNSGRILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHAL       PAEQQDFLFNQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQ       TCRIVQRELLFDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLY       NLPFKRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNG       TACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCK       ENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADG       LNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVG       VFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCG       SGVVGIVDYGPRPNKSEMWDVFCYRMKDVNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNFLTEVLAY       SNSSARGRAFLEHLTDLSIRGTLFVPQNSGLGENETLSGRDIEHHLANVSMFFYNDLVNGTTLQTRVG       SKLLITASQDPLQPTETRFVDGRAILQWDIFASNGIIHVISRPLKAPPAPVTLTHTGLGAGIFFAIIL       VTGAVALAAYSYFRINRRTIGFQHFESEEDINvAALGKQQPENISNPLYESTTSAPPEPSYDPFTDSE       ERQLEGNDPLRTL                                             NOV9b, 197408749   SEQ ID NO: 209   1668 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GGATCCAGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTT           AATACAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGC       CCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAG       GACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCC       CACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACA       TCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGT       GTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTAC       TTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAA       AGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGG       TGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCCTGCCC       TGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCACCGGAGAGT       GTAAATGCAACACCGGCTTCAATGGGACGGCATGTGAGATGTGCTGGCCGGGGAGATTTGGGCCTGAT       TGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAGTGCCT       CTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTACGCCTC       CTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAGGTGAC       GGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATG       CTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAGCTGCA       CAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGATGACA       GGCCCGGGCAAGCACAAGTGTGAGTGTAIAAGTCACTATGTCGGAGATGGGCTGAACTGTGGGCCGGA       GCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACC       TCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACC       TTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTCTCCTA       TGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTACCCCA       CAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATAGTGGACTATGGACCTAGACCCAAC       AAGAGTGAAATGTGGGATGTCTTCTGCTATCGGCCG                                                 NOV9b, 197408749   SEQ ID NO: 210   556 aa   MW at 60171.4kD               Protein Sequence                     GSRILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNK           DKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLG       VAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPFKPNLEGCRER       CSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPD       CLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGD       GITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMT       GPGKHKCECKSHYVGDGLNCGPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLT       FDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPN       KSEMWDVFCYRP                                             NOV9c, CG50736-01   SEQ ID NO: 211   2011 bp               DNA Sequence   ORF Start: ATG at 877   ORF Stop: TGA at 1822                       GGGTGTGATGGGCTTCTAGTTTCTCTAGCTGCATCACCCTTGAACCATCCAGAGTCCCAGTAAGCCAC               GGGCTTGAGCATGGAGGAGAATCCTCAGAGACAGAACCCCTGCCCACATGTCTGGGCCTTGCTCAAGC           CAGCAAGGGGCTGAATCCCTGTGTTTCAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCAC           ACCCCAGTCACTCTCTTCTGGCCCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTT           CCTGTTCAACCAAGACAACAAGGACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCA           AGGTTTTAGCTGTGGATCTTCCCACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTG           AAATGTGGAGCTGGCAGGGACATCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCG           GGAGCTCTTGTTTGACCTGGGTGTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGG           GCCGCTGTGACACCTTTACTACTTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGC           TGCCCAAGGTGGAGTAAACCAAAGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAA           CCTCGAAGGCTGCCGGGAGCGATGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCG           GGCGAGACTGTCAGGCCTGCCCTGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGAT           CAGTACTCGGCCACCGGAGAGTGTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAG   ATG TGCTG       GCCGGGGAGATTTGGGCCTGATTGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCA       TCACGGGCTCCGGGCAGTGCCTCTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTT       TTGTCTGCAGTGTGTACGCCTCCTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTG       TAACCTGGATTATGAAGGTGACGGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGG       GCTGTGCAAAGGTGGCCAGATGCTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATAC       AAAGGGGACGGGCACAGCTGCACAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGA       GCACGCCACCTGTAAGATGACAGGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAG       ATGGGCTGAACTGTGAGCCGGAGCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCAT       GCAGACGCCAAATGTGCCGACCTCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCC       ACTGGGCCAGTATAAGCTGACCTTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGG       CAACCTACAACCAGCTCTCCTATGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAG       ACCGGGCGGGTTGCCTACCCCACAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATAGT       GGACTATGGACCCAGACCCAACAAGAGTGAAATGTGGGATGTCTTCTGCTATCGGATGAAAGGAAGTG       CTGGCCTATTCCAACAGCTCAGCTCGAGGCCGTGCATTTCTAGAACACCTGAC TGA   CCTGTCCATCCG           CGGCACCCTCTTTGTGCCACAGAACAGTGGGCTGGGGGAGAATGAGACCTTGTCTGGGCGGGACATCG           AACACCACCTCGCCAATGTCAGCATGTTTTTCTACAATGACCTTGTCAATGGCACCACCCTGCAAACG           AGGCTGGGAAGCAAGCTGCTCATCACTGCCAGCCAGGAC                                                   NOV9c,CG50736-01   SEQ ID NO: 212   315 aa   MW at 33739.5kD               Protein Sequence                     MCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLSAVCTPPCSAHATCKENNT           CECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGG       CHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCADLHFQDTTVGVFHL       RSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVV       GIVDYGPRPNKSEMWDVFCYRMKGSAGLFQQLSSRPCISRTPD                                             NOV9d, CG50736-02   SEQ ID NO: 213   1804 bp               DNA Sequence   ORF Start: ATG at 877   ORF Stop: TGA at 1609                       GGGTGTGATGGGCTTCTAGTTTCTCTAGCTGCATCACCCTTGAACCATCCAGAGTCCCAGTAAGCCAC               GGGCTTGAGCATGGAGGAGAATCCTCAGAGACAQAACCCCTGCCCACATGTCTGGGCCTTGCTCAAGC           CAGCAAGGGGCTGAATCCCTGTGTTTCAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCAC           ACCCCAGTCACTCTCTTCTGGCCCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTT           CCTGTTCAACCAAGACAACAAGGACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCA           AGGTTTTAGCTGTGGATCTTCCCACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTG           AAATGTGGAGCTGGCAGGGACATCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCG           GGAGCTCTTGTTTGACCTGGGTGTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGG           GCCGCTGTGACACCTTTACTACTTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGC           TGCCCAAGGTGGAGTAAACCAAAGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAA           CCTGGAAGGCTGCCGGGAGCGATGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCG           GGCGAGACTGTCAGGCCTGCCCTGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGAT           CAGTACTCGGCCACCGGAGAGTGTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAG   ATG TGCTG       GCCGGGGAGATTTGGGCCTGATTGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCA       TCACGGGCTCCGGGCAGTGCCTCTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTT       TTGTCTGCAGTGTGTACGCCTCCTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTG       TAACCTGGATTATGAAGGTGACGGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGG       GCTGTGCAAAGGTGGCCAGATGCTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATAC       AAAGGGGACGGGCACAGCTGCACAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGA       GCACGCCACCTGTAAGATGACAGGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAG       ATGGGCTGAACTGTGAGCCGGAGCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCAT       GCAGACGCCAAATGTGTCGACCTCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCC       ACTGGGCCAGTATAAGCTGACCTTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGG       CAACCTACAACCAGCTCTCCTATGCCCAGAAGAGAGAAGAGAAA TGA   GTATGAAAGACCTGGGCACCT           ACAAGAAAGAGAGGACACTTTTGTTCACCCAGTGGCTCAATCAACCAGTCAACATCTAATGACCACCT           ACTGTGTGCCAGGCACAGAGGTGCAATAGGCAAAGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGC           AGACCGGGCGGGTTGCCTACCCCACAGCCTTCGCCT                                                   NOV9d, CG50736-02   SEQ ID NO: 214   244 aa   MW at 26106.9kD               Protein Sequence                     MCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLSAVCTPPCSANATCKENNT           CECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGG       CHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHL       RSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKREEK                                             NOV9e, CG50736-03   SEQ ID NO: 215   2512 bp               DNA Sequence   ORF Start: ATG at 416   ORF Stop: TAA at 2423                       ATAGGGCTCGAGCGGCTGCCCGGGCAGGTCTCATGCCTCAGCCTCCGGAGTAGTATTTTTAGTAGAGA               TGGTGTTTACCATGTGGGCCAGGCTGGTCTCGAACTCCTGGCCTCAAGTGATCCACCCGCCTCGGCCT           CCCAGAGTGCTGGGATTACAGGCATGAGCCACTGCACCCAGCCTTGTTTGTATTTTGAATTCCAAATG           GAAATACCTTCATGATCTTCCCACTACTAAAGGTTTAAATCTGGCACTGATACCTCTCCAAGAGGGCT           ATATACTATGCAGTGTTTCCCAGCATGTTTCACAAGAAAATTCTTTTTTGAGGATCATCTCACAGAAC           TTGGGATCTTTGCAACATGTATTGTGAAATCCAGGCCAGAGGAACCCCATGTTCCTTCCACACTGATA           TTCCACA   ATG GAGGCAAGAAAGGAGCTAGAGTCACTTCCTCCCTTTTGTCTGAACAGCCTCCACTCTA       TAATCCTGACCACAAAGCTTACTTCCCAGAGTCTGGGTGGGCCGAGAGGTGTGGAAGAGAGAATGGAG       GACAGGAGAGCCAAATGGCACATTGCAGCAAAAGACTCCTGCCTCTGGCTGAAACCCTCTGATCTTCT       GTTACAGGTTAAAGACTGGGACAAATACGGTTTAATGCCCCAGGTTCTTCGGTACCATGTGGTCGCCT       GCCACCAGCTGCTTCTGGAAAACCTGAAATTGATCTCAAATGCTACTTCCCTCCAAGGAGAGCCAATA       GTCATCTCCGTCTCTCAGAGCACGGTGTATATAAACAATAAGGCTAAGATCATATCCAGTGATATCAT       CAGTACTAATGGGATTGTTCATATCATAGACAAATTGCTATCTCCCAAAAATTTGCTTATCACTCCCA       AAGACAACTCTGGAAGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTT       AGCAACTTAATACAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCT       CTTCTGGCCCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAG       ACAACAAGGACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTG       GATCTTCCCACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGACGTGG       CAGGGACATCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGCGAGCTCTTGTTTG       ACCTGGGTGTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACC       TTTACTACTTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAG       TAAACCAAAGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCC       GGGAGCGGTGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAG       GCCTGCCCTGGAGGACCAGTTGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCAC       CGGAGAGTGTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTTG       GGCCTGATTGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGG       CAGTGCCTCTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGTCTGCAGTGTG       TACGCCTCCTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATG       AAGGTGACGGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTG       GCCAGATGCTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCA       CAGCTGCACAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTA       AGATGACAGGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGT       GAGCCGGAGCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATG       TGTCGACCTCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATA       AGCTGACCTTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAG       CTCTCCTATGCCCAGAAGACCTGGTATTCCTTTACCAAGGAA TAA   AGCCTTTGATGCCAGGACCCAGA           CTCAAGGAGAATCTGAATCTCTGCTCTCCTGCTTGCTGGTCATGTGGCCTTGATATCAAGCCAC                                                   NOV9e, CG50736-03   SEQ ID NO: 216   669 aa   MW at 73167.6kD               Protein Sequence                     MEARKELESLPPFCLNSLHSIILTTKLTSQSLGGPRGVEERMEDRRAKWHIAAKDSCLWLKPSDLLLQ           VKDWDKYGLMPQVLRYHVVACHQLLLENLKLTSNATSLQGEPIVISVSQSTVYINNKAKIISSDIIST       NGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFW       PTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRD       IGDLFLNGQTCRIVQRELLFDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKP       KGVKQKCLYNLPFKRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPVAPCNNRGVCLDQYSATGE       CKCNTGFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLSAVCTP       PCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSC       TEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVD       LHFQDTTVGVFHLRSPLGQYKLTFDKEACANEAATMATYNQLSYAQKTWYSFTKE                                             NOV9f, CG50736-04   SEQ ID NO: 217   2483 bp               DNA Sequence   ORF Start: ATG at 387   ORF Stop: TAA at 2394                       CTCATGCCTCAGCCTCCGGAGTAGTATTTTTAGTAGAGATGGTGTTTACCATGTGGGCCAGGCTGGTC               TCGAACTCCTGGCCTCAAGTGATCCACCCGCCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGC           CACTGCACCCAGCCTTGTTTGTATTTTGAATTCCAAATGGGAATTCCTTCATGATCTTCCCACTACTA           AAGGTTTAAATCTGGCACTGATACCTCTCCAAGAGGGCTATATACTATGCAGTGTTTCCCAGCATGTT           TCACAAGAAAATTCTTTTTTGAGGATCATCTCACAGAACTTGGGATCTTTGCAACATGTATTGTGAAA           TCCAGGCCAGAGGAACCCCATGTTCCTTCCACACTGATATTCCACA   ATG GAGGCAAGAAAGGAGCTAG       AGTCACTTCCTCCCTTTTGTCTGAACAGCCTCCACTCTATAATCCTGACCACAAAGCTTACTTCCCAG       AGTCTGGGTGGGCCGAGAGGTGTGGAAGAGAGAATGGAGGACAGGAGAGCCAAATGGCACATTGCAGC       AAAAGACTCCTGCCTCTGGCTGAAACCCTCTGATCTTCTGTTACAGGTTAAAGACTGGGACAAATACG       GTTTAATGCCCCAGGTTCTTCGGTACCATGTGGTCGCCTGCCACCAGCTGCTTCTGGAAAACCTGAAA       TTGATCTCAAATGCTACTTCCCTCCAAGGAGAGCCAATAGTCATCTCCGTCTCTCAGAGCACGGTGTA       TATAAACAATAAGGCTAAGATCATATCCAGTGATATCATCAGTACTAATGGGATTGTTCATATCATAG       ACAAATTGCTATCTCCCAAAAATTTGCTTATCACTCCCAAAGACAACTCTGGAAGAATTCTGCAAAAT       CTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTTAATACAGGACTCAGGTTTGCT       GAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGCCCACCGACCAAGCCCTCCATG       CCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAGGACAAGCTGAAGGAGTATTTG       AAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCCCACATCCACTGCCTGGAAGAC       CCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACATCGGTGACCTCTTTCTGAATG       GCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGTGTGGCCTACGGCATTGACTGT       CTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTACTTTCGATGCCTCGGGGGAGTG       TGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAAACCAAAGGGTGTGAGCAGAAGTGTC       TCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGATGCAGCCTGGTGATACAGATC       CCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCCTGCCCTGGAGGACCAGATGCCCCGTG       TAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCdACCGGAGAGTGTAAATGCAACACCGGCTTCA       ATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTTGGGCCTGATTGTCTGCCCTGTGGCTGCTCA       GACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAGTGCCTCTGTGAAACGGGGTGGACAGG       CCCCTCGTGTGACACTCAGGCAGTTTTGTCTGCAGTGTGTACGCCTCCTTGTTCTGCTCATGCCACCT       GTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAGGTGACGGAATCACATGCACAGTTGTG       GATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATGCTCCCAGAAGGGCACGAAGGT       CTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAGCTGCACAGAGATAGACCCCTGTGCAG       ACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGATGACAGGCCCGGGCAAGCACAAGTGT       GAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAGCCGGAGCAGCTGCCCATTGACCGCTG       CTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACCTCCACTTCCAGGATACCACTG       TTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACCTTTGACAAAGCCAGAGAGGCC       TGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTCTCCTATGCCCAGAAGACCTGGTATTC       CTTTACCAAGGAA TAA   AGCCTTTGATGCCAGGACCCAGACTCAAGGAGAATCTGAATCTCTGCTCTCC           TGCTTGCTGGTCATGTGGCCTTGATATCAAGCCAC                                                   NOV9f, CG50736-04   SEQ ID NO: 218   669 aa   MW at 73183.5kD               Protein Sequence                     MEARKELESLPPFCLNSLHSIILTTKLTSQSLGGPRGVEERMEDRPAKWHIAAKDSCLWLKPSDLLLQ           VKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVSQSTVYINNKAKIISSDIIST       NGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFW       PTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRD       IGDLFLNGQTCRIVQRELLFDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKP       KGVKQKCLYNLPFKRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGE       CKCNTGFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLSAVCTP       PCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSC       TEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVD       LHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKTWYSFTKE                                             NOV9g, CG50736-05   SEQ ID NO: 219   1353 bp               DNA Sequence   ORF Start: at 1   ORF Stop: TAA at 1264                     CTTCCCACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAG           GGACATCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACC       TGGGTGTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTT       ACTACTTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAA       ACCAAAGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGG       AGCGATGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCC       TGCCCTGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCACCGG       AGAGTGTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTTGGGC       CTGATTGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAG       TGCCTCTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGTCTGCAGTGTGTAC       GCCTCCTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAG       GTGACGGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCC       AGATGCTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAG       CTGCACAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGA       TGACAGGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAG       CCGGAGCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGT       CGACCTCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGC       TGACCTTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTC       TCCTATGCCCAGAAGACCTGGTATTCCTTTACCAAGGAA TAA   AGCCTTTGATGCCAGGACCCAGACTC           AAGGAGAATCTGAATCTCTGCTCTCCTGCTTGCTGGTCATGTGGCCTTGATATCAAGCCAC                                                   NOV9g, CG50736-05   SEQ ID NO: 220   421 aa   MW at 45276.6kD               Protein Sequence                     LPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVAYGIDCLLIDPTLGGRCDTF           TTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPFKRNLEGCRERCSLVIQIPRCCKGYFGRDCQA       CPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQ       CLCETGWTGPSCDTQAVLSAVCTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVA       RCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCE       PEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATYNQL       SYAQKTWYSFTKE                                             NOV9h, CG50736-06   SEQ ID NO: 221   3625 bp               DNA Sequence   ORF Start: ATG at 387   ORF Stop: TAG at 2022                       CTCATGCCTCAGCCTCCGGAGTAGTATTTTTAGTAGAGATGGTGTTTACCATGTGGGCCAGGCTGGTC               TCGAACTCCTGGCCTCAAGTGATCCACCCGCCTCGGCCTCCCAGACTGCTGGGATTACAGGCATGAGC           CACTGCACCCAGCCTTGTTTGTATTTTGAATTCCAAATGGAAATACCTTCATGATCTTCCCACTACTA           AAGGTTTAAATCTGGCACTGATACCTCTCCAAGAGGGCTATATACTATGCAGTGTTTCCCAGCATGTT           TCACAAGAAAATTCTTTTTTGAGGATCATCTCACAGAACTTGGGATCTTTGCAACATGTATTGTGAAA           TCCAGGCCAGAGGAACCCCATGTTCCTTCCACACTGATATTCCACA   ATG GAGGCAAGAAAGGAGCTAG       AGTCACTTCCTCCCTTTTGTCTGAACAGCCTCCACTCTATAATCCTGACCACAAAGCTTACTTCCCAG       AGTCTGGGTGGGCCGAGAGGTGTGGAAGAGAGAATGGAGGACAGGAGAGCCAAATGGCACATTGCAGC       AAAAGACTCCTGCCTCTGGCTGAAACCCTCTGATCTTCTGTTACAGGTTAAAGACTGGGACAAATACG       GTTTAATGCCCCAGGTTCTTCGGTACCATGTGGTCGCCTGCCACCAGCTGCTTCTGGAAAACCTGAAA       TTGATCTCAAATGCTACTTCCCTCCAAGGAGAGCCAATAGTCATCTCCGTCTCTCAGAGCACGGTGTA       TATAAATAATAAGGCTAAGATCATATCCAGTGATATCATCAGTACTAATGGGATTGTTCATATCATAG       ACAAATTGCTATCTCCCAAAAATTTGCTTATCACTCCCAAAGACAACTCTGGAAGAATTCTGCAAAAT       CTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTTAATACAGGACTCAGGTTTGCT       GAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGCCCACCGACCAAGCCCTCCATG       CCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAGGACAAGCTGAAGGAGTATTTG       AAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCCCACATCCACTGCCTGGAAGAC       CCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACATCGGTGACCTCTTTCTGAATG       GCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGTGTGGCCTACGGCATTGACTGT       CTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTACTTTCGATGCCTCGGGGGAGTG       TGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAAAGGGTGTGAAGCAGAAGTGTC       TCTACAACCTGCCCTTCAAGAGGAACCTGQAAGGCTGCCGGGAGCGGTGCAGCCTGGTGATACAGATC       CCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGGTGAGGGTGCCTCTTCCCCCCTCGCAAC       TCTAAAAGTGTCTGCCTTGATCAGTACTCGGCCACCGGAGAGTGTAAATGCAACACCGGCTTCAATGG       GACGGCGTGTGAGATGTGCTGGCCGGGGAGATTTGGGCCTGATTGTCTGCCCTGTGGCTGCTCAGACC       ACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAGTGCCTCTGTGAAACGGGGTGGACAGGCCCC       TCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTACGCCTCCTTGTTCTGCTCATGCCACCTGTAA       GGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAGGTGACGGAATCACATGCACAGTTGTGGATT       TCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATGCTCCCAGAAGGGCACGAAGGTCTCC       TGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAGCTGCACAGAGA TAG   ACCCCTGTGCAGACGG           CCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGATGACAGGCCCGGGCAAGCACAAGTGTGAGT           GTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAGCCGGAGCAGCTGCCCATTGACCGCTGCTTA           CAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACCTCCACTTCCAGGATACCACTGTTGG           GGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACCTTTGACAAAGCCAGAGAGGCCTGTG           CCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTCTCCTATGCCCAGAAGGCCAAGTACCACCTG           TGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTACCCCACAGCCTTCGCCTCCCAGAACTGTGG           CTCTGGTGTGGTTGGGATAGTGGACTATGGACCTAGACCCAACAAGAGTGAAATGTGGGATGTCTTCT           GCTATCGGATGAAAGGAAGTGCTGGCCTATTCCAACAGCTCAGCTCGAGGCCGTGCATTTCTAGAACA           CCTGACTGACCTGTCCATCCGCGGCACCCTCTTTGTGCCACAGAACAGTGGGCTGGGGGAGAATGAGA           CCTTGTCTGGGCGGGACATCGAGCACCACCTCGCCAATGTCAGCATGTTTTTCTACAATGACCTTGTC           AATGGCACCACCCTGCAAACGAGGCTGGGAAGCAAGCTGCTCATCACTGCCAGCCAGGACCCACTCCA           ACCGACGGAGACCAGGTTTGTTGATGGAAGAGCCATTCTGCAGTGGGACATCTTTGCCTCCAATGGGA           TCATTCATGTCATTTCCAGGCCTTTAAAAGCACCCCCTGCCCCCGTGACCTTGACCCACACTGGCTTG           GGAGCAGGGATCTTCTTTGCCATCATCCTGGTGACTGGGGCTGTTGCCTTGGCTGCTTACTCCTACTT           TCGGCAAGCAGCAGCCTGAGAATATCTCGAACCCCTTGTATGAGAGCACAACCTCAGCTCCCCCAGAA           TTGGCAAGCAGCAGCCTGAGAATATCTCGAACCCCTTGTATGAGAGCACAACCTCAGCTCCCCCAGAA           CCTTCCTACGACCCCTTCACGGACTCTGAAGAACGGCAGCTTGAGGGCAATGACCCCTTGAGGACACT           GTGAGGGCCTGGACGGGAGATGCCAGCCATCACTCACTGCCACCTGGGCCATCAACTGTGAATTCTCA           GCACCAGTTGCCTTTTAGGAACGTAAAGTCCTTTAAGCACTCAGAAGCCATACCTCATCTCTCTGGCT           GATCTGGGGGTTGTTTCTGTGGGTGAGAGATGTGTTGCTGTGCCCACCCAGTACAGCTTCCTCCTCTG           ACCCTTTGGCTCTTCTTCCTTTGTACTCTTCAGCTGGCACCTGCTCCATTCTGCCCTACATGATGGGT           AACTGTGATCTTTCTTCCCTGTTAGATTGTAAGCCTCCGTCTTTGTATCCCAGCCCCTAGCCCAGTGC           CTGACACAGGAACTGTGCACAATAAAGGTTTATGGAACAGAAACAAAGTCAAAAAAAAAAAAAAAAAA           AAAAAAAAAAAAAAAAAAAAC                                                   NOV9h, CG50736-06   SEQ ID NO: 222   545 aa   MW at 60038.8kD               Protein Sequence                     MEARKELESLPPFCLNSLHSIILTTKLTSQSLGGPRGVEERMEDRRAKWHIAAKDSCLWLKPSDLLLQ           VKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVSQSTVYINNKAKIISSDIIST       NGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFW       PTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRD       IGDLFLNGQTCRIVQRELLFDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKP       KGVKQKCLYNLPFKRNLEGCRERCSLVIQIPRCCKGYFGRDCQGEGASSPLATLKVSALISTRPPESV       NATPASMGRRVRCAGRGDLGLIVCPVAAQTTDSAMMASRAPGSASVKRGGQAPRVTLRQFCLQCVRLL       VLLMPPVRRTTRVSVTWIMKVTESHAQLWISANRTTGAVQRWPDAPRRARRSPAAARRDTKGTGTAAQ       R                                             NOV9i, CG50736-07   SEQ ID NO: 223   1624 bp               DNA Sequence   ORF Start: ATG at 387   ORF Stop: TAA at 1530                       CTCATGCCTCAGCCTCCGGAGTAGTATTTTTAGTAGAGATGGTGTTTACCATGTGGGCCAGGCTGGTC               TCGAACTCCTGGCCTCAAGTGATCCACCCGCCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGC           CACTGCACCCAGCCTTGTTTGTATTTTGAATTCCAAATGGAAATACCTTCATGATCTTCCCACTACTA           AAGGTTTAAATCTGGCACTGATACCTCTCCAAGAGGGCTATATACTATGCAGTGTTTCCCAGCATGTT           TCACAAGAAAATTCTTTTTTGAGGATCATCTCACAGAACTTGGGATCTTTGCAACATGTATTGTGAAA           TCCAGGCCAGAGGAACCCCATGTTCCTTCCACACTGATATTCCACA   ATG GAGGCAAGAAAGGAGCTAG       AGTCACTTCCTCCCTTTTGTCTGAACAGCCTCCACTCTATAATCCTGACCACAAAGCTTACTTCCCAG       AGTCTGGGTGGGCCGAGAGGTGTGGAAGAGAGAATGGAGGACAGGAGAGCCAAATGGCACATTGCAGC       AAAAGACTCCTGCCTCTGGCTGAAACCCTCTGATCTTCTGTTACAGGTTAAAGACTGGGACAAATACG       GTTTAATGCCCCAGGTTCTTCGGTACCATGTGGTCGCCTGCCACCAGCTGCTTCTGGAAAACCTGAAA       TTGATCTCAAATGCTACTTCCCTCCAAGGAGAGCCAATAGTCATCTCCGTCTCTCAGAGCACGGTGTA       TATAAACAATAAGGCTAAGATCATATCCAGTGATATCATCAGTACTAATGGGATTGTTCATATCATAG       ACAAATTGCTATCTCCCAAAAATTTGCTTATCACTCCCAAAGACAACTCTGGAAGAATTCTGCAAAAT       CTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTTAATACAGGACTCAGGTTTGCT       GAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGCCCACCGACCAAGCCCTCCATG       CCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAGGACAAGCTGAAGGAGTATTTG       AAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCCCACATCCACTGCCTGGAAGAC       CCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACATCGGTGACCTCTTTCTGAATG       GCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGTGTGGCCTACGGCATTGACTGT       CTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTACTTTCGATGCCTCGGGGGAGTG       TGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAAAGGGTGTGAAGCAGAAGTGTC       TCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGGTGCAGCCTGGTGATACAGATC       CCCAGCCTGCCCTGGAGGACCAGATGCCCCGTG TAA   TAACCGGGGTGTCTGCCTTGATCAGTACTCGG           CCACCGGAGAGTGTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGC                                                   NOV9i, CG50736-07   SEQ ID NO: 224   381 aa   MW at 42565.8kD               Protein Sequence                     MEARKELESLPPFCLNSLHSIILTTKLTSQSLGGPRGVEERMEDRRAKWHIAAKDSCLWLKPSDLLLQ           VKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVSQSTVYINNKAKIISSDIIST       NGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFW       PTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRD       IGDLFLNGQTCRIVQRELLFDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKP       KGVKQKCLYNLPFKRNLEGCRERCSLVIQIPSLPWRTRCPV                                             NOV9j, CG50736-08   SEQ ID NO: 225   1857 bp               DNA Sequence   ORF Start: at 1   ORF Stop: TAA at 1768                     GTTCTTCGGTACCATGTGGTCGCCTGCCACCAGCTGCTTCTGGAAAACCTGAAATTGATCTCAAATGC           TACTTCCCTCCAAGGAGAGCCAATAGTCATCTCCGTCTCTCAGAGCACGGTGTATATAAACAATAAGG       CTAAGATCATATCCAGTGATATCATCAGTACTAATGGGATTGTTCATATCATAGACAAATTGCTATCT       CCCAAAAATTTGCTTATCACTCCCAAAGACAACTCTGGAAGAATTCTGCAAAATCTTACGACTTTGGC       AACAAACAATGGCTACATCAAATTTAGCAACTTAATACAGGACTCAGGTTTGCTGAGTGTCATCACCG       ATCCCATCCACACCCCAGTCACTCTCTTCTGGCCCACCGACCAAGCCCTCCATGCCCTACCTGCTGAA       CAACAGGACTTCCTGTTCAACCAAGACAACAAGGACAAGCTGAAGGAGTATTTGAAGTTTCATGTGAT       ACGAGATGCCAAGGTTTTAGCTGTGGATCTTCCCACATCCACTGCCTGGAAGACCCTGCAAGGTTCAG       AGCTGAGTGTGAAATGTGGAGCTGGCAGGGACATCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGA       ATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGTGTGGCCTACGGCATTGACTGTCTGCTGATTGATCC       CACCCTGGGGGGCCGCTGTGACACCTTTACTACTTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCA       ATACTCCCAGCTGCCCAAGGTGGAGTAAACCAAAGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCC       TTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGATGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAA       GGGCTACTTCGGGCGAGACTGTCAGGCCTGCCCTGGAGGACCAGATGCCCCGTGTAATAACCGGGGTG       TCTGCCTTGATCAGTACTCGGCCACCGGAGAGTGTAAATGCAACACCGGCTTCAATGGGACGGCGTGT       GAGATGTGCTGGCCGGGGAGATTTGGGCCTGATTGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTG       CGATGATGGCATCACGGGCTCCGGGCAGTGCCTCTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACA       CTCAGGCAGTTTTGTCTGCAGTGTGTACGCCTCCTTGTTCTGCTCATGCCACCTGTAAGGAGAACAAC       ACGTGTGAGTGTAACCTGGATTATGAAGGTGACGGAATCACATGCACAGTTGTGGATTTCTGCAAACA       GGACAACGGGGGCTGTGCAAAGGTGGCCAGATGCTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCC       AGAAGGGATACAAAGGGGACGGGCACAGCTGCACAGAGATAGACCCCTGTGCAGACGGCCTTAACGGA       GGGTGTCACGAGCACGCCACCTGTAAGATGACAGGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCA       CTATGTCGGAGATGGGCTGAACTGTGAGCCGGAGCAGCTGCCCATTGACCGCTGCTTACAGGACAATG       GGCAGTGCCATGCAGACGCCAAATGTGTCGACCTCCACTTCCAGGATACCACTGTTGGGGTGTTCCAT       CTACGCTCCCCACTGGGCCAGTATAAGCTGACCTTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGC       TGCGACCATGGCAACCTACAACCAGCTCTCCTATGCCCAGAAGACCTGGTATTCCTTTACCAAGGAA T           AA   AGCCTTTGATGCCAGGACCCAGACTCAAGGAGAATCTGAATCTCTGCTCTCCTGCTTGCTGGTCAT           GTGGCCTTGATATCAAGCCAC                                                   NOV9j, CG50736-08   SEQ ID NO: 226   589 aa   MW at 63994.0kD               Protein Sequence                     VLRYHVVACHQLLLENLKLISNATSLQGEPIVISVSQSTVYINNKAKIISSDIISTNGIVHIIDKLLS           PKNLLITPKDNSGRILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE       QQDFLFNQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCR       IVQRELLFDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLP       FKRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTAC       EMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLSAVCTPPCSAHATCKENN       TCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNG       GCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFH       LRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKTWYSFTKE                                             NOV9k, CG50736-10   SEQ ID NO: 227   8495 bp               DNA Sequence   ORF Start: ATG at 210   ORF Stop: TGA at 7461                       AATCATCCCACATGCTAAGAATCTAAGATGTATAAAATAAAGTGGTGAAAGATGAAAATGAAATTTTA               TCAAGGTTAGAGTCAGGTTGGAGTGGCCATTGTTTACCAAACTGAGAAATCTAAATTTTATTTGGTTG           GTAATTGAGAGTCATTGAGATATTTTGGGGAAGGTCACCCTGATGCCTTTGCTAATCAAATGAAATGA           ATGAA   ATG GAGAGGCAAGAAACTGGAAATAGCAAGACGAGGTATCATGCTACTGCAATAGTCCAGGCA       AAACATGATAAAGGCCTCAACAAGAATGGCACCAGTGGAGATGAAGAGCAGAAGATCAAGGTGGGAGA       CAGAGACAGAGAAAACAAAGGATTTGATGGCTTATTAGATGTTTGGAATACTTTAAACTTTATTCATC       CTTGCTTTGCTGTGTGCAACTGTGTGCATGGGGTGTGCAACAGTGGACTAGATGGCGATGGAACCTGT       GAGTGCTACTCTGCGTACACTGGCCCCAAGTGTGACAAGCTCACAGAAAACTTTCACACCTCTCATCT       GACACTGTGGCCTGTGCACGACTCCAAGCACTGGGGAAGCCTTCGACATCAGAATATGAATGGCACCT       GTTCTTCCGGGGGCGGCAAGGGGGATCCCGATGTTTATCAAAATGGGTTGATTTTCCACGGAGGGGGT       ACTTCTGGAGGTCTATCGTCATCACGAAACAGACGAAGTAGTGTCAAGCGTCCTGAGAAGTGGAAGGG       GGACGATCGAGATGGAGGTGGCAAGGAAGGCCAGCAGCGGCGGCGGGCAGACACAGAGTCGAGTCTTC       AAAGAGGTCACATCAAAACGCCCCTGCCCCACAGGCAAGGTGAAGCGCGGATCACGGAGACAACGGGG       AATTGTGTTTCTGCTGGCATGACTGGAACCAATGCCAATCACACAAAAGTTCACCCTACGGTTCAGTC       CTTGACAGAATATGATTCCTTTCAGACTCATTCCACCAGCAGACTGAAGGAATTTGAGAAACAGCAGG       TGAAGGAAAGATTTTCTGACCCTCCCCTAATGCAGGCTATAAAACCCTCACATGAGAAGTACCCTCCT       TATGCCCAGAGAAAAGGAACATCTTTGTCTCCAAAGACACAGGGACACGGAGATGATGAACAGGCCTT       GCTAAGTTTCCTCCACTCTATTACCCTTAGCTTGTACCTTTATCCAACCACATTCTTCCATGACTCTC       CAGTCTTCATCAAACCTGGCATAAAAACACTCAGACTTAACCACTTCTTTGGGTCTTCATTTCCTTAT       GAAGGCTCCAGTGTCATANNNNNNATGGGAATTGAGGTTTGGAAAAACTGGTGCCAAAATGCTGATAC       CCTGGCTGCTGCCCCTGCTCCATCCCTGAATGTGCAGCCTTGCTCTGCCCAGAAAATTCCAGATGTTC       GCCTTCCACTGAAGATGAAAACAAACTGGAATGCAAATGCCTTCCCAATTACCGAGGCGATGGCAAAT       ACTGCGACCCCATCAATCCATGTTTACGAAAAATCTGCCACCCTCATGCTCATTGTACGTACCTGGGA       CCAAATCGGCACAGTTGTACATGCCAAGAAGGCTACCGTGGGGATGGCCAAGTGTGCTTGCCTGTGGA       CCCCTGCCAAATTAACTTTGGAAACTGCCCTACAAAGTCTACAGTGTGCAAATATGATGGGCCTGGAC       AGATGCATTTGCCAGAAAGGTTACGTGGGTGATGGCTTAACGTGTTATGGAAACATTATGGAGCGACT       CAGAGAATTAAATACTGAACCCAGAGGAAAATGGCAAGGAAGGCTGACCTCTTTCATCTCACTCCTAG       AAAGTATACAAATTGTAAGTGTACAACTCAGTGAATTTTCCCAACGTGAACCTACTTGTGTAAACACC       AAGTCCATTGCCAGCAACCTAGAAGGCCCCCTGGTCCCCCTTTCCAATCATTACCCTCTACAGGTAAA       TGAGCTTTTGGTGGATAATAAAGCTGCTCAATACTTTGTGAAACTCCACATAATTGCTGGTCAGATGA       ACATCGAATATATGAATAACACAGACATGTTCTACACCTTGACTGGAAAGTCGGGGGAAATCTTCAAC       AGCGATAAGGACAATCAAATAAAGCTTAAACTCCATGGAGGCAAAAAGAAGGTAAAAATTATACAAGG       GGACATCATTGCTTCCAATGGGCTTCTGCACATCCTTGACAGAGCCATGGACAAGTTAGAACCCACAT       TTGAGAGCAACAATGAGGALACCAATTTGGGACATGCCTTAGATGAGGATGGAGTTGGTGGACCATAC       ACCATTTTTGTTCCAAATAATGAAGCATTGAATAACATGAAGGACGGCACTCTCGATTACCTCCTTTC       TCCAGAGCTTGAAGTGGCCACTCTCATCTCCACCCCTCACATCAGGAGCATGGCCAACCAGCTCATAC       AGTTCAACACCACCGACAATGGACAGATTCTGGCAAATGATGTGGCAATGGAAGAAATTGAGATCACT       GCCAAAAATGGCCGAATTTACACACTGACAGGAGTTCTCATTCCTCCCTCCATTGTCCCGATTCTGCC       CCATCGATGTGATGAAACAAAGAGAGAGATGAAACTGGGCACTTGTGTGAGCTGTTCTCTGGTGTACT       GGAGCAGATGTCCTGCTAACTCTGAGCCCACAGCACTCTTCACACACAGATGTGTCTACAGTGGCAGG       TTTGGGAGCCTGAAGAGCGGCTGTGCCCGGTACTGCAATGCCACTGTGAAGTGTGCAGATAGCCTCGG       CGGCAACGGGACATGCATTTGTGAGGAGGGCTTCCAAGGCTCCCAGTGTCAGTTCTGCTCTGATCCCA       ATAAATACGGACCTCGGTGTAACAAAAAATGCCTGTGCGTTCACGGAACATGCAATAACAGGATAGAC       AGCGATGGGGCCTGCCTCACTGGCACATGCAGAGACGGCTCTGCCGGGAGACTCTGTGATAAGCAGAC       CTCAGCCTGTGGGCCCTACGTGCAGTTCTGTCACATCCACGCCACCTGTGAATACAGCAATGGGACAG       CCAGTTGTATTTGCAAAGCAGGATATGAAGGAGATGGAACTCTGTGTTCTGAGATGGACCCTTGCACA       GGACTAACTCCAGGAGGCTGTAGCCGCAATGCAGAATGCATCAAAACTGGCACGGGCACCCACACCTG       CGTGTGTCAGCAGGGTTGGACAGGGAATGGGAGAGACTGCTCGGAGATCAACAACTGCCTGCTGCCCA       GTGCAGGCGGCTGCCACGACAACGCATCCTGTTTGTATGTGGGTCCCGGGCAGAATGAGTGTGAGTGC       AAGAAAGGATTTCGAGGAAATGGGATTGACTGTGAACCAATAACTTCATGCTTGGAACAAACCGGGAA       ATGTCATCCATTGGCAAGCTGTCAATCTACTTCGTCTGGTGTCTGGAGCTGTGTTTGTCAAGAGGGCT       ATGAAGGAGATGGCTTTCTGTGCTATGGAAACGCAGCAGTGGAATTGTCATTTCTCTCCGAAGCAGCT       ATATTTAACCGATGGATAAATAATGCTTCTCTACAACCCACACTGTCAGCCACCTCAAACCTCACTGT       CCTCGTGCCTTCCCAACAAGCTACTGAGGACATGGACCAGGATGAGAAAAGCTTCTGGTTGTCACAGA       GCAATATTCCAGCCCTAATAAAGTACCATATGCTACTAGGCACATACAGAGTGGCAGATCTGCAGACC       CTGTCTTCTTCTGACATGTTGGCAACATCTTTGCAGGGCAACTTCCTTCACTTGGCAAAGGTGGATGG       GAATATCACAATTGAAGGGGCCTCCATTGTCGATGGGGACAACGCAGCCACAAATGGAGTGATACACA       TCATCAACAAGGTGCTGGTCCCACAAAGACGTCTAACTGGCTCCTTACCAAACCTGCTCATGCGGCTG       GAACAGATGCCTGACTATTCCATCTTCCGGGGCTACATCATTCAATATAATCTGGCGAATGCAATTGA       GGCTGCCGATGCCTACACAGTGTTTGCTCCAAACAACAATGCCATCGAGAATTACATCAGGGAGAAGA       AAGTCTTGTCTCTAGAGGAGGACGTCCTCCGGTATCATGTGGTCCTGGAGGAGAAACTCCTGAAGAAT       GACCTGCACAATGGCATGCATCGTGAGACCATGCTGGGTTTCTCCTATTTCCTTAGCTTCTTTCTCCA       TAATGACCAGCTCTATGTAAATGAGGCTCCAATAAACTACACCAATGTAGCCACTGATAAGGGAGTGA       TCCATGGTTTGGGAAAAGTTCTGGAAATTCAGAAGAACAGATGTGATAATAATGACACTACTATTATA       CGAGGAAGATGTAGGACATGCTCCTCAGAGCTGACCTGCCCATTCGGAACTAAATCTCTAGGTAATGA       GAAGAGGAGATGCATCTATACCTCCTATTTCATGGGAAGACGAACCCTGTTTATTGGGTGCCAGCCAA       AATGTGTGAGAACCGTCATTACGAGAGAATGCTGTGCCGGCTTCTTTGGCCCCCAATGCCAGCCCTGC       CCAGGGAATGCCCAGAATGTCTGCTTTGGTAATGGCATCTGTTTGGATGGAGTGAATGGCACAGGTGT       GTGTGAGTGTGGGGAGGGCTTCAGCGGCACAGCCTGCGAGACCTGCACCGAGGGCAAGTACGGCATCC       ACTGTGACCAAGCATGTTCTTGTGTCCATGGGAGATGCAACCAAGGACCCTTGGGAGATGGCTCCTGT       GACTGTGATGTTGGCTGGCGAGGAGTGCATTGTGACAATGCAACCACAGAAGACAACTGCAATGGGAC       ATGCCATACCAGCGCCAACTGCCTCACCAACTCAGATGGTACAGCTTCATGCAAGTGTGCAGCAGGAT       TCCAAGGAAACGGGACCATCTGCACAGCAATCAATGCCTGTGAGATCAGCAATGGAGGTTGCTCTGCC       AAGGCTGACTGTAAGAGAACCACCCCAGGAAGGCGAGTGTGCACGTGCAAAGCAGGCTACACGGGTGA       TGGCATTGTGTGCCTGGAAATCAACCCGTGTTTGGAGAACCATGGTGGCTGTGACAAGAATGCGGAGT       GCACACAGACAGGACCCAACCAGGCTGCCTGTAACTGTTTGCCAGCATACACTGGAGATGGAAAGGTC       TGCACACTCATCAATGTCTGCTTAACTAAAAATGGCGGCTGTAGTGAATTTGCCATCTGCAACCACAC       TGGGCAAGTAGAAAGGACTTGTACTTGCAAGCCAAACTACATTGGAGATGGATTTACCTGCCGCGGCA       GCATTTATCAGGAGCTTCCCAAGAACCCGAAAACTTCCCAGTATTTCTTCCAGTTGCAGGAGCATTTC       GTGAAAGATCTGGTCGGCCCAGGCCCCTTCACTGTTTTTGCACCTTTATCTGCAGCCTTTGATGAGGA       AGCTCGGGTTAAAGACTGGGACAAATACGGTTTAATGCCCCAGGTTCTTCGGTACCATGTGGTCGCCT       GCCACCAGCTGCTTCTGGAAAACCTGAAATTGATCTCAAATGCTACTTCCCTCCAAGGAGAGCCAATA       GTCATCTCCGTCTCTCAGAGCACGGTGTATATAAACAATAAGGCTAAGATCATATCCAGTGATATCAT       CAGTACTAATGGGATTGTTCATATCATAGACAAATTGCTATCTCCCAAAAATTTGCTTATCACTCCCA       AAGACAACTCTGGAAGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTT       AGCAACTTAATACAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCT       CTTCTGGCCCACCGACCAAGCCCTCCATGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGT       TCAACCAAGACAACAAGGACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTT       TTAGCTGTGGATCTTCCCACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATG       TGGAGCTGGCAGGGACATCGGTGACCTCTTTCTGAATGGCCAAACCTACAGAATTGTGCAGCGGGAGC       TCTTGTTTGACCTGGGTGTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGC       TGTGACACCTTTACTACTTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCC       AAGGTGGAGTAAACCAAAGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGG       AAGGCTGCCGGGAGCGGTGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGA       GACTGTCAGGCCTGCCCTGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTA       CTCGGCCACCGGAGAGTGTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGG       GGAGATTTGGGCCTGATTGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCACG       GGCTCCGGGCAGTGCCTCTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCC       TGCAGTGTGTACGCCTCCTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACC       TGGATTATGAAGGTGACGGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGT       GCAAAGGTGGCCAGATGCTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACAAAGG       GGACGGGCACAGCTGCACAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACG       CCACCTGTAAGATGACAGGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGG       CTGAACTGTGAGCCGGAGCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGA       CGCCAAATGTGTCGACCTCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGG       GCCAGTATAAGCTGACCTTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACC       TACAACCAGCTCTCCTATGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGG       GCGGGTTGCCTACCCCACAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATAGTGGACT       ATGGACCTAGACCCAACAAGAGTGAAATGTGGGATGTCTTCTGCTATCGGATGAAAGGAAGTGCTGGC       CTATTCCAACAGCTCAGCTCGAGGCCGTGCATTTCTAGAACACCTGAC TGA   CCTGTCCATCCGCGGCA           CCCTCTTTGTGCCACAGAACAGTGGGCTGGGGGAGAATGAGACCTTGTCTGGGCGGGACATCGAGCAC           CACCTCGCCAATGTCAGCATGTTTTTCTACAATGACCTTGTCAATGGCACCACCCTGCAAACGAGGCT           GGGAAGCAAGCTGCTCATCACTGCCAGCCAGGACCCACTCCAACCGACGGAGACCAGGTTTGTTGATC           GAAGAGCCATTCTGCAGTGGGACATCTTTGCCTCCAATGGGATCATTCATGTCATTTCCAGGCCTTTA           AAAGCACCCCCTGCCCCCGTGACCTTGACCCACACTGGCTTGGGAGCAGGGATCTTCTTTGCCATCAT           CCTGGTGACTGGGGCTGTTGCCTTGGCTGCTTACTCCTACTTTCGGATAAACCGGAGAACAATCGGCT           TCCAGCATTTTGAGTCGGAAGAGGACATTAATGTTGCAGCTCTTGGCAAGCAGCAGCCTGAGAATATC           TCGAACCCCTTGTATGAGAGCACAACCTCAGCTCCCCCAGAACCTTCCTACGACCCCTTCACGGACTC           TGAAGAACGGCAGCTTGAGGGCAATGACCCCTTGAGGACACTGTGAGGGCCTGGACGGGAGATGCCAC           CCATCACTCACTGCCACCTGGGCCATCAACTGTGAATTCTCAGCACCAGTTGCCTTTTAGGAACGTAA           AGTCCTTTAAGCACTCAGAAGCCATACCTCATCTCTCTGGCTGATCTGGGGGTTGTTTCTGTGGGTGA           GAGATGTGTTGCTGTGCCCACCCAGTACAGCTTCCTCCTCTGACCCTTTGGCTCTTCTTCCTTTGTAC           TCTTCAGCTGGCACCTGCTCCATTCTGCCCTACATGATGGGTAACTGTGATCTTTCTTCCCTGTTAGA           TTGTAAGCCTCCGTCTTTGTATCCCAGCCCCTAGCCCAGTGCCTGACACAGGAACTGTGCACAATAAA           GGTTTATGGAACAGAAACAAAGTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAC                                                   NOV9k, CG50736-10   SEQ ID NO: 228   2417 aa   MW at 262971.8kD               Protein Sequence                     MERQETGNSKTRYHATAIVQAKHDKGLNKNGTSGDEEQKIKVGDRDRENKGFDGLLDVWNTLNFIHPC           FAVCNCVHGVCNSGLDGDGTCECYSAYTGPKCDKLTENFHTSHLTLWPVHDSKHWGSLRHQNMNGTCS       SGGGKGDPDVYQNGLIFHGGGTSGGLSSSRNRRSSVKRPEKWKGDDRDGGGKEGQQRRRADTESSLQR       GHIKTPLPHRQGEARITETTGNCVSAGMTGTNANHTKVHPTVQSLTEYDSFQTHSTSRLKEFEKQQVK       ERFSDPPLMQAIKPSHEKYPPYAQRKGTSLSPKTQGHGDDEQALLSFLHSITLSLYLYPTTFFHDSPV       FIKPGIKTLRLNHFFGSSFPYEGSSVIXXMGIEVWKNWCQNADTLAAAPAPSLNVQPCSAQKIPDVRL       PLKMKTNWNANAFPITEAMANTATPSIHVYEKSATLMLIVRTWDQIGTVVHAKKATVGMAKCACLWTP       AKLTLETALQSLQCANNMGLDRCICQKGYVGDGLTCYGNIMERLRELNTEPRGKWQGRLTSFISLLES       IQIVSVQLSEFSQREPTCVNTKSIASNLEGPLVPLSNHYPLQVNELLVDNKAAQYFVKLHIIAGQNNI       EYMNNTDMFYTLTGKSGEIFNSDKDNQIKLKLHGGKKKVKIIQGDIIASNGLLHILDRAMDKLEPTFE       SNNEETNLGHALDEDGVGGPYTIFVPNNEALNNMKDGTLDYLLSPELEVATLISTPHIRSMANQLIQF       NTTDNGQILANDVAMEEIEITAKNGRIYTLTGVLIPPSIVPILPHRCDETKREMKLGTCVSCSLVYWS       RCPANSEPTALFTHRCVYSGRFGSLKSGCARYCNATVKCADSLGGNGTCICEEGFQGSQCQFCSDPNK       YGPRCNKKCLCVHGTCNNRIDSDGACLTGTCRDGSAGRLCDKQTSACGPYVQFCHIHATCEYSNGTAS       CICKAGYEGDGTLCSEMDPCTGLTPGGCSRNAECIKTGTGTHTCVCQQGWTGNGRDCSEINNCLLPSA       GGCHDNASCLYVGPGQNECECKKGFRGNGIDCEPITSCLEQTGKCHPLASCQSTSSGVWSCVCQEGYE       GDGFLCYGNAAVELSFLSEAAIFNRWINNASLQPTLSATSNLTVLVPSQQATEDMDQDEKSFWLSQSN       IPALIKYHMLLGTYRVADLQTLSSSDMLATSLQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHII       NKVLVPQRRLTGSLPNLLMRLEQMPDYSIFRGYIIQYNLANAIEAADAYTVFAPNNNAIENYIREKKV       LSLEEDVLRYHVVLEEKLLKNDLHNGMHRETMLGFSYFLSFFLHNDQLYVNEAPINYTNVATDKGVIH       GLGKVLEIQKNRCDNNDTTIIRGRCRTCSSELTCPFGTKSLGNEKRRCIYTSYFMGRRTLFIGCQPKC       VRTVITRECCAGFFGPQCQPCPGNAQNVCFGNGICLDGVNGTGVCECGEGFSGTACETCTEGKYGIHC       DQACSCVHGRCNQGPLGDGSCDCDVGWRGVHCDNATTEDNCNGTCHTSANCLTNSDGTASCKCAAGFQ       GNGTICTAINACEISNGGCSAKADCKRTTPGRRVCTCKAGYTGDGIVCLEINPCLENHGGCDKNAECT       QTGPNQAACNCLPAYTGDGKVCTLINVCLTKNGGCSEFAICNHTGQVERTCTCKPNYIGDGFTCRGSI       YQELPKNPKTSQYFFQLQEHFVKDLVGPGPFTVFAPLSAAFDEEARVKLWDKYGLMPQVLRYHVVACH       QLLLENLKLISNATSLQGEPIVISVSQSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKD       NSGRILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALHALPAEQQDFLFN       QDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTYRIVQRELL       FDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPFKRNLEG       CRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGR       FGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLD       YEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHAT       CKMTGPGKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQ       YKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYG       PRPNKSEMWDVFCYRMKGSAGLFQQLSSRPCISRTPD                                             NOV9l, CG50736-11   SEQ ID NO: 229   1599 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     AGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTTAATACA           GGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGCCCACCG       ACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAGGACAAG       CTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCCCACATC       CACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACATCGGTG       ACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGTGTGGCC       TACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTACTTTCGA       TGCCTCGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGG       AGCGGTGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCC       TGCCCTGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCACCGG       AGAGTGTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTCGGGC       CTGATTGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAG       TGCCTCTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTAC       GCCTCCTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAG       GTGACGGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCC       AGATGCTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAG       CTGCACAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGA       TGACAGGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAG       CCGGAGCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGT       CGACCTCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGC       TGACCTTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTC       TCCTATGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTA       CCCCACAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATAGTGGACTATGGACCTAGAC       CCAACAAGAGTGAAATGTGGGATGTCTTCTGCTAT                                                 NOV9l, CG50736-11   SEQ ID NO: 230   533 aa   MW at 57827.8kD               Protein Sequence                     RILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDK           LKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVA       YGIDCLLIDPTLGGRCDTFTTFDASGVKQKCLYNLPFKRNLEGCRERCSLVIQIPRCCKGYFGRDCQA       CPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQ       CLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVA       RCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCE       PEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATYNQL       YAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY                                             NOV9m, CG50736-12   JSEQ ID NO: 231   1611 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 1606                       GGATCC AGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTT           AATACAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGC       CCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAG       GACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCC       CACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACA       TCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGT       GTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTAC       TTTCGATGCCTCGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCT       GCCGGGAGCGGTGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGT       CAGGCCTGCCCTGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGC       CACCGGAGAGTGTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGAT       TCGGGCCTGATTGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCACGGGCTCC       GGGCAGTGCCTCTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGT       GTGTACGCCTCCTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATT       ATGAAGGTGACGGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAG       GTGGCCAGATGCTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGG       GCACAGCTGCACAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCT       GTAAGATGACAGGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAAC       TGTGAGCCGGAGCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAA       ATGTGTCGACCTCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGT       ATAAGCTGACCTTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAAC       CAGCTCTCCTATGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGT       TGCCTACCCCACAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATAGTGGACTATGGAC       CTAGACCCAACAAGAGTGAAATGTGGGATGTCTTCTGCTATCGG CGG                                                   NOV9m, CG50736-12   SEQ ID NO: 232   533 aa   MW at 57827.8kD               Protein Sequence                     RILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDK           LKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVA       YGIDCLLIDPTLGGRCDTFTTFDASGVKQKCLYNLPFKRNLEGCRERCSLVIQIPRCCKGYFGRDCQA       CPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQ       CLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVA       RCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCE       PEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATYNQL       SYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY                                             NOV9n, CG50736-13   SEQ ID NO: 233   1668 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 1663                       GGATCC AGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTT           AATACAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGC       CCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAG       GACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCC       CACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACA       TCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGT       GTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTAC       TTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAA       AGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGG       TGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCCTGCCC       TGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCACCGGAGAGT       GTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTCGGGCCTGAT       TGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCAATGATGGCATCACGGGCTCCGGGCAGTGCCT       CTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTACGCCTC       CTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAGGTGAC       GGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATG       CTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAGCTGCA       CAGAGATAGACCCTTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGATGACA       GGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAGCCGGA       GCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACC       TCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACC       TTTGACAGAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTCTCCTA       TGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTACCCCA       CAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATAGTGGACTATGGACCTAGACCCAAC       AAGAGTGAAATGTGGGATGTCTTCTGCTATCGG CCG                                                   NOV9n, CG50736-13   SEQ ID NO: 234   552 aa   MW at 59873.1kD               Protein Sequence                     RILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDK           LKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVA       YGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPFKRNLEGCRERCS       LVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCL       PCGCSDHGQCNDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGI       TCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCKNTGP       GKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFD       RAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKS       EMWDVFCY                                             NOV9o, CG50736-14   SEQ ID NO: 235   1668 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 1663                       GGATCC AGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTT           AATACAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGC       CCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAG       GACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCC       CACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACA       TCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGT       GTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTCACTAC       TTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAA       AGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGG       TGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCCTGCCC       TGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCTGTACTCGGCCACCGGAGAGT       GTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTCGGGCCTGAT       TGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAGTGCCT       CTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTACGCCTC       CTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAGGTGAC       GGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATG       CTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAGCTGCA       CAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGATGACA       GGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAGCCGGA       GCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACC       TCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACC       TTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTCTCCTA       TGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTACCCCA       CAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATAGTGGACTATGGACCTAGACCCAAC       AAGAGTGAAATGTGGGATGTCTTCTGCTATCGG CCG                                                   NOV9o, CG50736-14   SEQ ID NO: 236   552 aa   MW at 59831.1kD               Protein Sequence                     RILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDK           LKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVA       YGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPFKRNLEGCRERCS       LVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDLYSATGECKCNTGFNGTACEMCWPGRFGPDCL       PCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGI       TCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGP       GKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFD       KAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKS       EMWDVFCY                                             NOV9p, CG50736-15   SEQ ID NO: 237   1668 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 1663                       GGATCC AGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTT           AATACAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGC       CCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAG       GACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCC       CACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACA       TCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGT       GTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTAC       TTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAA       AGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGG       TGCAGTCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCCTGCCC       TGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCACCGGAGAGT       GTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTCGGGCCTGAT       TGTCTGCCCTGCGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAGTGCCT       CTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTACGCCTC       CTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAGGTGAC       GGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATG       CTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAGCTGCA       CAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGATGACA       GGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAGCCGGA       GCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACC       TCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACC       TTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTCTCCTA       TGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTACCCCA       CAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATAGTGGACTATGGACCTAGACCCAAC       AAGAGTGAAATGTGGGATGTCTTCTGCTATCGG CCG                                                   NOV9p, CG50736-15   SEQ ID NO: 238   552 aa   MW at 59846.1kD               Protein Sequence                     RILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDK           LKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVA       YGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPFKRNLEGCRERCS       LVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCL       PCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGI       TCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGP       GKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFD       KAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKS       EMWDVFCY                                             NOV9q, CG50736-16   SEQ ID NO: 239   1668 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 1663                       GGATCC AGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTT           AATACAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGC       CCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAG       GACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCC       CACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACA       TCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGT       GTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTAC       TTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAA       AGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGG       TGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCCTGCCC       TGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCACCGGAGAGT       GTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTTGGGCCTGAT       TGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAGTGCCT       CTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTACGCCTC       CTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTTACCTGGATTATGAAGGTGAC       GGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATG       CTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAGCTGCA       CAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCCGTAAGATGACA       GGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAGCCGGA       GCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACC       TCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACC       TTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTCTCCTA       TGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTACCCCA       CAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATAGTGGACTATGGACCTAGACCCAAC       AAGAGTGAAATGTGGGATGTCTTCTGCTATCGG CCG                                                   NOV9q, CG50736-16   SEQ ID NO: 240   552 aa   MW at 59948.2kD               Protein Sequence                     RILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDK           LKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVA       YGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPFKRNLEGCRERCS       LVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCL       PCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECYLDYEGDGI       TCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATRKMTGP       GKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFD       KAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKS       EMWDVFCY                                             NOV9r, CG50736-17   SEQ ID NO: 241   1668 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 1663                       GGATCC AGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTT           AATACAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGC       CCACCGACCAAGCCCTCCATGCCCTACCTGCTGA~CAACAGGACTTCCTGTTCAACCAAGACAACAAG       GACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCC       CACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACA       TCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGT       GTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTAC       TTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAA       AGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGG       TGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCCTGCCC       TGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCACCGGAGAGT       GTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTCGGGCCTGAT       TGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAGTGCCT       CTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTACGCCTC       CTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAGGTGAC       GGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATG       CTCCCAGAAGGGCACGAAGGTCTCCTGCAACTGCCAGAAGGGGTACAAAGGGGACGGGCACAGCTGCA       CAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGATGACA       GGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAGCCGGA       GCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACC       TCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACC       TTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTCTCCTA       TGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTACCCCA       CAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATAGTGGACTATGGACCTAGACCCAAC       AAGAGTGAAATGTGGGATGTCTTCTGCTATCGG CCG                                                   NOV9r, CG50736-17   SEQ ID NO: 242   552 aa   MW at 59873.1kD               Protein Sequence                     RILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDK           LKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVA       YGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPFKRNLEGCRERCS       LVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCL       PCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGI       TCTVVDFCKQDNGGCAKVARCSQKGTKVSCNCQKGYKGDGHSCTETDPCADGLNGGCHEHATCKMTGP       GKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFD       KAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKS       EMWDVFCY                                             NOV9s, CG50736-18   SEQ ID NO: 243   1668 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 1663                       GGATCC AGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTT           AATACAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGC       CCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAG       GACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCC       CACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACA       TCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGT       GTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTAC       TTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAA       AGGGTGTGAAGCAGAGGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGG       TGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCCTGCCC       TGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCACCGGAGAGT       GTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTCGGGCCTGAT       TGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAGTGCCT       CTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTACGCCTC       CTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAGGTGAC       GGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATG       CAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGATGACA       GGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAGCCGGA       GCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACC       TCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACC       TTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTCTCCTA       TGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTACCCCA       CAGCCTTCGCCTCCCAGAACTGTGGCTCTAGTGTGGTTGGGATAGTGGACTATGGACCTAGACCCAAC       AAGAGTGAAATGTGGGATGTCTTCTGCTATCGG CCG                                                   NOV9s, CG50736-18   SEQ ID NO: 244   552 aa   MW at 59904.1kD               Protein Sequence                     RILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDK           LKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVA       YGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQRCLYNLPFKRNLEGCRERCS       LVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCL       PCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGI       TCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCKNTGP       GKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFD       KAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSSVVGIVDYGPRPNKS       EMWDVFCY                                             NOV9t, CG50736-19   SEQ ID NO: 245   1668 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 1663                       GGATCC AGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTT           AATACAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGC       CCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAG       GACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCC       CACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACA       TCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGT       GTGGCCTGCGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTAC       TTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAA       AGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGG       TGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCCTGCCC       TGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCACCGGAGAGT       GTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTTGGGCCTGAT       TGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAGTGCCT       CTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTACGCCTC       CTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAGGTGAC       GGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATG       CTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAGCTGCA       CAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGATGACA       GGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAGCCGGA       GCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACC       TCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACC       TTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTCTCCTA       TGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTACCCCA       CAGCCTTCGCCTCCCAGAACTGCGGCTCTGGTGTGGTTGGGATAGTGGACTATGGACCTAGACCCAAC       AAGAGTGAAATGTGGGATGTCTTCTGCTATCGG CCG                                                   NOV9t, CG50736-19   SEQ ID NO: 246   552 aa   MW at 59786.0kD               Protein Sequence                     RILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDK           LKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVA       CGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPFKRNLEGCRERCS       LVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCL       PCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGI       TCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGP       GKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFD       KAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKS       EMWDVFCY                                             NOV9u, CG50736-20   SEQ ID NO: 247   1668 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 1663                       GGATCC AGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTT           AATACAGGACTCAGGTTTGCTGAGTGTCGTCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGC       CCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAG       GACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCC       CACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACA       TCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGT       GTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTAC       TTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAA       AGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGG       TGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCCTGCCC       TGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCACCGGAGAGT       GTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTCGGGCCTGAT       CTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTACGCCTC       CTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAGGTGAC       GGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATG       CTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAGCTGCA       CAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGATGACA       GGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAGCCGGA       GCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACC       TCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACC       TTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCACGGCAACCTACAACCAGCTCTCCTA       TGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTACCCCA       CAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATAGTGGACTATGGACCTAGACCCAAC       AAGAGTGAAATGTGGGATGTCTTCTGCTATCGG CCG                                                   NOV9u, CG50736-20   SEQ ID NO: 248   552 aa   MW at 59802.0kD               Protein Sequence                     RILQNLTTLATNNGYIKFSNLIQDSGLLSVVTDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDK           LKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVA       YGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPFKRNLEGCRERCS       LVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCL       PCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGI       TCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGP       GKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFD       KAREACANEAATTATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKS       EMWDVFCY                                             NOV9v, CG50736-21   SEQ ID NO: 249   1668 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 1663                       GGATCC AGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTT           AATACAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGC       CCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAG       GACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCC       CACATCCACTGCCTGGAAGACCCTTCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACA       TCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGT       GTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTAC       TTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAA       AGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGG       TGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCCTGCCC       TGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCACCGGAGAGT       GTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTCGGGCCTGAT       TGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAGTGCCT       CTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTACGCCTC       CTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAGGTGAC       GGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATG       CTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAGCTGCA       CAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGATGACA       GGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAGCCGGA       GCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACC       TCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACC       TTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTCTCCTA       TGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTACCCCA       CAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATAGTGGACTATGGACCTAGACCCAAC       AAGAGTGAAATGTGGGATGTCTTCTGCTATCGG CCG                                                   NOV9V, CG50736-21   SEQ ID NO: 250   552 aa   MW at 59846.1kD               Protein Sequence                     RILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDK           LKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVA       YGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPFKRNLEGCRERCS       LVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCL       PCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGI       TCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGP       GKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFD       KAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKS       EMWDVFCY                                             NOV9w, CG50736-22   SEQ ID NO: 251   4527 bp               DNA Sequence   ORF Start: ATG at 4   ORF Stop: TGA at 4510                   GAC   ATG GACCAGGATGAGAAAAGCTTCTGGTTGTCACAGAGCAATATTCCAGCCCTAATAAAGTACCA       TATGCTACTAGGCACATACAGAGTGGCAGATCTGCAGACCCTGTCTTCTTCTGACATGTTGGCAACAT       CTTTGCAGGGCAACTTCCTTCACTTGGCAAAGGTGGATGGGAATATCACAATTGAAGGGGCCTCCATT       GTCGATGGGGACAACGCAGCCACAAATGGAGTGATACACATCATCAACAAGGTGCTGGTCCCACAAAG       ACGTCTAACTGGCTCCTTACCAAACCTGCTCATGCGGCTGGAACAGATGCCTGACTATTCCATCTTCC       GGGGCTACATCATTCAATATAATCTGGCGAATGCAATTGAGGCTGCCGATGCCTACACAGTGTTTGCT       CCAAACAACAATGCCATCGAGAATTACATCAGGGAGAAGAAAGTCTTGTCTCTAGAGGAGGACGTCCT       CCGGTATCATGTGGTCCTGGAGGAGAAACTCCTGAAGAATGACCTGCACAATGGCATGCATCGTGAGA       CCATGCTGGGTTTCTCCTATTTCCTTAGCTTCTTTCTCCACAATGACCAGCTCTATGTAAATGAGGCT       CCAATAAACTACACCAATGTAGCCACTGATAAGGGAGTGATCCATGGCTTGGGAAAAGTTCTGGAAAT       TCAGAAGAACAGATGTGATAATAATGACACTACTATTATACGAGGAAGATGTAGGACATGCTCCTCAG       AGCTGACCTGCCCATTCGGAACTAAATCTCTAGGTAATGAGAAGAGGAGATGCATCTATACCTCCTAT       TTCATGGGAAGACGAACCCTGTTTATTGGGTGCCAGCCAAAATGTGTGAGAACCGTCATTACGAGAGA       ATGCTGTGCCGGCTTCTTTGGCCCCCAATGCCAGCCCTGCCCAGGGAATGCCCAGAATGTCTGCTTTG       GTAATGGCATCTGTTTGGATGGAGTGAATGGCACAGGTGTGTGTGAGTGTGGGGAGGGCTTCAGCGGC       ACAGCCTGCGAGACCTGCACCGAGGGCAAGTACGGCATCCACTGTGACCAAGCATGTTCTTGTGTCCA       TGGGAGATGCAACCAAGGACCCTTGGGAGATGGCTCCTGTGACTGTGATGTTGGCTGGCGAGGAGTGC       ATTGTGACAATGCAACCACAGAAGACAACTGCAATGGGACATGCCATACCAGCGCCAACTGCCTCACC       AACTCAGATGGTACAGCTTCATGCAAGTGTGCAGCAGGATTCCAAGGAAACGGGACCATCTGCACAGC       AATCAATGCCTGTGAGATCAGCAATGGAGGTTGCTCTGCCAAGGCTGACTGTAAGAGAACCACCCCAG       GAAGGCGAGTGTGCACGTGCAAAGCAGGCTACACGGGTGATGGCATTGTGTGCCTGGAAATCAACCCG       TGTTTGGAGAACCATGGTGGCTGTGACAAGAATGCGGAGTGCACACAGACAGGACCCAACCAGGCTGC       CTGTAACTGTTTGCCAGCATACACTGGAGATGGAAAGGTCTGCACACTCATCAATGTCTGCTTAACTA       AAAATGGCGGCTGTGGTGAATTTGCCATCTGCAACCACACTGGGCAAGTAGAAAGGACTTGTACTTGC       AAGCCAAACTACATTGGAGATGGATTTACCTGCCGCGGCAGCATTTATCAGGAGCTTCCCAAGAACCC       GAAAACTTCCCAGTATTTCTTCCAGTTGCAGGAGCATTTCGTGAAAGATCTGGTCGGCCCAGGCCCCT       TCACTGTTTTTGCACCTTTATCTGCAGCCTTTGATGAGGAAGCTCGGGTTAAAGACTGGGACAAATAC       GGTTTAATGCCCCAGGTTCTTCGGTACCATGTGGTCGCCTGCCACCAGCTGCTTCTGGAAAACCTGAA       ATTGATCTCAAATGCTACTTCCCTCCAAGGAGAGCCAATAGTCATCTCCGTCTCTCAGAGCACGGTGT       ATATAAACAATAAGGCTAAGATCATATCCAGTGATATCATCAGTACTAATGGGATTGTTCATATCATA       GACAAATTGCTATCTCCCAAAAATTTGCTTATCACTCCCAAAGACAACTCTGGAAGAATTCTGCAAAA       TCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTTAATACAGGACTCAGGTTTGC       TGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGCCCACCGACCAAGCCCTCCAT       GCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAAGACACAAGGACAAGCTGAAGGAGTATTT       GAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCCCACATCCACTGCCTGGAAGA       CCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACATCGGTGACCTCTTTCTGAAT       GGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGTGTGGCCTACGGCATTGACTG       TCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTACTTTCGATGCCTCGGGGGAGT       GTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAAAGGGTGTGAAGCAGAAGTGT       CTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGGTGCAGCCTGGTGATACAGAT       CCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGCCTCGCAACTCTAAAAGTGTCTGCCTTG       ATCAGTACTCGGCCACCGGAGAGTGTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGC       TGGCCGGGGAGATTTGGGCCTGATTGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGG       CATCACGGGCTCCGGGCAGTGCCTCTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAG       TTTTGCCTGCAGTGTGTACGCCTCCTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAG       TGTAACCTGGATTATGAAGGTGACGGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGG       GGGCTGTGCAAAGGTGGCCAGATGCTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGAT       ACAAAGGGGACGGGCACAGCTGCACAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCAC       GAGCACGCCACCTGTAAGATGACAGGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGG       AGATGGGCTGAACTGTGAGCCGGAGCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCC       ATGCAGACGCCAAATGTGTCGACCTCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCC       CCACTGGGCCAGTATAAGCTGACCTTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCAT       GGCAACCTACAACCAGCTCTCCTATGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGG       AGACCGGGCGGGTTGCCTACCCCACAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATA       GTGGACTATGGACCTAGACCCAACAAGAGTGAAATGTGGGATGTCTTCTGCTATCGGATGAAAGATGT       GAACTGCACCTGCAAGGTGGGCTATGTGGGAGATGGCTTCTCATGCAGTGGGAACCTGCTGCAGGTCC       TGATGTCCTTCCCCTCACTCACAAACTTCCTGACGGAAGTGCTGGCCTATTCCAACAGCTCAGCTCGA       GGCCGTGCATTTCTAGAACACCTGACTGACCTGTCCATCCGCGGCACCCTCTTTGTGCCACAGAACAG       TGGGCTGGGGGAGAATGAGACCTTGTCTGGGCGGGACATCGAGCACCACCTCGCCAATGTCAGCATGT       TTTTCTACAATGACCTTGTCAATGGCACCACCCTGCAAACGAGGGTGGGAAGCAAGCTGCTCATCACT       GCCAGCCAGGACCCACTCCAACCGACGGAGACCAGGTTTGTTGATGGAAGAGCCATTCTGCAGTGGGA       CATCTTTGCCTCCAATGGGATCATTCATGTCATTTCCAGGCCTTTAAAAGCACCCCCTGCCCCCGTGA       CCTTGACCCACACTGGCTTGGGAGCAGGGATCTTCTTTGCCATCATCCTGGTGACTGGGGCTGTTGCC       TTGGCTGCTTACTCCTACTTTCGGATAAACCGGAGAACAATCGGCTTCCAGCATTTTGAGTCGGAAGA       GGACATTAATGTTGCAGCTCTTGGCAAGCAGCAGCCTGAGAATATCTCGAACCCCTTGTATGAGAGCA       CAACCTCAGCTCCCCCAGAACCTTCCTACGACCCCTTCACGGACTCTGAAGAACGGCAGCTTGAGGGC       AATGACCCCTTGAGGACACTG TGA   GGGCCTGGACGGGAG                                                   NOV9w, CG50736-22   SEQ ID NO: 252   1502 aa   MW at 163589.6kD               Protein Sequence                     MDQDEKSFWLSQSNIPALIKYHMLLGTYRVADLQTLSSSDMLATSLQGNFLHLAKVDGNITIEGASIV           DGDNAATNGVIHIINKVLVPQRRLTGSLPNLLMRLEQMPDYSIFRGYIIQYNLANAIEAADAYTVFAP       NNNAIENYIREKKVLSLEEDVLRYHVVLEEKLLKNDLHNGMHRETMLGFSYFLSFFLHNDQLYVNEAP       INYTNVATDKGVIHGLGKVLEIQKNRCDNNDTTIIRGRCRTCSSELTCPFGTKSLGNEKRRCIYTSYF       MGRRTLFIGCQPKCVRTVITRECCAGFFGPQCQPCPGNAQNVCFGNGICLDGVNGTGVCECGEGFSGT       ACETCTEGKYGIHCDQACSCVHGRCNQGPLGDGSCDCDVGWRGVHCDNATTEDNCNGTCHTSANCLTN       SDGTASCKCAAGFQGNGTICTAINACEISNGGCSAKADCKRTTPGRRVCTCKAGYTGDGIVCLEINPC       LENHGGCDKNAECTQTGPNQAACNCLPAYTGDGKVCTLINVCLTKNGGCGEFAICNHTGQVERTCTCK       PNYIGDGFTCRGSIYQELPKNPKTSQYFFQLQEHFVKDLVGPGPFTVFAPLSAAFDEEARVKDWDKYG       LMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVSQSTVYINNKAKIISSDIISTNGIVHIID       KLLSPKNLLITPKDNSGRILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHA       LPAEQQDFLFNQDNKDKLKEYLKFHVIRDAXVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNG       QTCRIVQRELLFDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCL       YNLPFKRNLEGCRERCSLVIQIPRCCKGYFGRDCQPRNSKSVCLDQYSATGECKCNTGFNGTACEMCW       PGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCEC       NLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHE       HATCKMTGPGKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSP       LGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIV       DYGPRPNKSEMWDVFCYRMKDVNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNFLTEVLAYSNSSARG       RAFLEHLTDLSIRGTLFVPQNSGLGENETLSGRDIEHHLANVSMFFYNDLVNGTTLQTRVGSKLLITA       SQDPLQPTETRFVDGPAILQWDIFASNGIIHVISRPLKAPPAPVTLTHTGLGAGIFFAIILVTGAVAL       AAYSYFRINRRTIGFQHFESEEDINVAALGKQQPENISNPLYESTTSAPPEPSYDPFTDSEERQLEGN       DPLRTL                                             NOV9x, CG50736-23   SEQ ID NO: 253   5416 bp               DNA Sequence   ORF Stan: ATG at 478   ORF Stop: TGA at 5008                       GTAGAATGCATCAAAACTGGCACGGGCACCCACACCTGCGTGTGTCAGCAGGGTTGGACAGGGAATGG               GAGAGACTGCTCGGAGATCAACAACTGCCTGCTGCCCAGTGCAGGCGGCTGCCACGACAACGCATCCT           GTTTGTATGTGGGTCCCGGGCAGAATGAGTGTGAGTGCAAGAAAGGATTTCGAGGAAATGGGATTGAC           TGTGCACCAATAACTTCATGCTTGGAACAAACCGGGAAATGTCATCCATTGGCAAGCTGTCAATCTAC           TTCGTCTGGTGTCTGGAGCTGTGTTTGTCAAGAGGGCTATGAAGGAGATGGCTTTCTGTGCTATGGAA           ACGCAGCAGTGGAATTGTCATTTCTCTCCGAAGCAGCTATATTTAACCGATGGATAAATAATGCTTCT           CTACAACCCACACTGTCAGCCACCTCAAACCTCACTGTCCTCGTGCCTTCCCAACAAGCTACTGAGGA           C   ATG GACCAGGATGAGAAAAGCTTCTGGTTGTCACAGAGCAATATTCCAGCCCTAATAAAGTACCATA       TGCTACTAGGCACATACAGAGTGGCAGATCTGCAGACCCTGTCTTCTTCTGACATGTTGGCAACATCT       TTGCAGGGCAACTTCCTTCACTTGGCAAAGGTGGATGGGAATATCACAATTGAAGGGGCCTCCATTGT       CGATGGGGACAACGCAGCCACAAATGGAGTGATACACATCATCAACAAGGTGCTGGTCCCACAAAGAC       GTCTAACTGGCTCCTTACCAAACCTGCTCATGCGGCTGGAACAGATGCCTGACTATTCCATCTTCCGG       GGCTACATCATTCAATATAATCTGGCGAATGCAATTGAGGCTGCCGATGCCTACACAGTGTTTGCTCC       AAACAACAATGCCATCGAGAATTACATCAGGGAGAAGAAAGTCTTGTCTCTAGAGGAGGACGTCCTCC       GGTATCATGTGGTCCTGGAGGAGAAACTCCTGAAGAATGACCTGCACAATGGCATGCATCGTGAGACC       ATGCTGGGTTTCTCCTATTTCCTTAGCTTCTTTCTCCACAATGACCAGCTCTATGTAAATGAGGCTCC       AATAAACTACACCAATGTAGCCACTGATAAGGGAGTGATCCATGGCTTGGGAAAAGTTCTGGAAATTC       AGAAGAACAGATGTGATAATAATGACACTACTATTATACGAGGAAGATGTAGGACATGCTCCTCAGAG       CTGACCTGCCCATTCGGAACTAAATCTCTAGGTAATGAGAAGAGGAGATGCATCTATACCTCCTATTT       CATGGGAAGACGAACCCTGTTTATTGGGTGCCAGCCAAAATGTGTGAGAACCGTCATTACGAGAGAAT       GCTGTGCCGGCTTCTTTGGCCCCCAATGCCAGCCCTGCCCAGGGAATGCCCAGAATGTCTGCTTTGGT       AATGGCATCTGTTTGGATGGAGTGAATGGCACAGGTGTGTGTGAGTGTGGGGAGGGCTTCAGCGGCAC       AGCCTGCGAGACCTGCACCGAGGGCAAGTACGGCATCCACTGTGACCAAGCATGTTCTTGTGTCCATG       GGAGATGCAACCAAGGACCCTTGGGAGATGGCTCCTGTGACTGTGATGTTGGCTGGCGAGGAGTGCAT       TGTGACAATGCAACCACAGAAGACAACTGCAATGGGACATGCCATACCAGCGCCAACTGCCTCACCAA       CTCAGATGGTACAGCTTCATGCAAGTGTGCAGCAGGATTCCAAGGAAACGGGACCATCTGCACAGCAA       TCAATGCCTGTGAGATCAGCAATGGAGGTTGCTCTGCCAAGGCTGACTGTAAGAGAACCACCCCAGGA       AGGCGAGTGTGCACGTGCAAAGCAGGCTACACGGGTGATGGCATTGTGTGCCTGGAAATCAACCCGTG       TTTGGAGAACCATGGTGGCTGTGACAAGAATGCGGAGTGCACACAGACAGGACCCAACCAGGCTGCCT       GTAACTGTTTGCCAGCATACACTGGAGATGGAAAGGTCTGCACACTCATCAATGTCTGCTTAACTAAA       AATGGCGGCTGTAGTGAATTTGCCATCTGCAACCACACTGGGCAAGTAGAAAGGACTTGTACTTGCAA       GCCAAACTACATTGGAGATGGATTTACCTGCCGCGGCAGCATTTATCAGGAGCTTCCCAAGAACCCGA       AAACTTCCCAGTATTTCTTCCAGTTGCAGGAGCACTTCGTGAAAGATCTGGTCGGCCCAGGCCCCTTC       ACTGTTTTTGCACCTTTATCTGCAGCCTTTGATGAGGAAGCTCGGGTTAAAGACTGGGACAAATACGG       TTTAATGCCCCAGGTTCTTCGGTACCATGTGGTCGCCTGCCACCAGCTGCTTCTGGAAAACCTGAAAT       TGATCTCAAATGCTACTTCCCTCCAAGGAGAGCCAATAGTCATCTCCGTCTCTCAGAGCACGGTGTAT       ATAAACAATAAGGCTAAGATCATATCCAGTGATATCATCAGTACTAATGGGATTGTTCATATCATAGA       CAAATTGCTATCTCCCAAAAATTTGCTTATCACTCCCAAAGACAACTCTGGAAGAATTCTGCAAAATC       TTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTTAATACAGGACTCAGGTTTGCTG       AGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGCCCACCGACCAAGCCCTCCATGC       CCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAGGACAAGCTGAAGGAGTATTTGA       AGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCCCACATCCACTGCCTGGAAGACC       CTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACATCGGTGACCTCTTTCTGAATGG       CCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGTGTGGCCTACGGCATTGACTGTC       TGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTACTTTCGATGCCTCGGGGGAGTGT       GGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAAAGGGTGTGAAGCAGAAGTGTCT       CTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGGTGCAGCCTGGTGATACAGATCC       CCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCCTGCCCTGGAGGACCAGATGCCCCGTGT       AATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCACCGGAGAGTGTAAATGCAACACCGGCTTCAA       TGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTTGGGCCTGATTGTCTGCCCTGTGGCTGCTCAG       ACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAGTGCCTCTGTGAAACGGGGTGGACAGGC       CCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTACGCCTCCTTGTTCTGCTCATGCCACCTG       TAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAGGTGACGGAATCACATGCACAGTTGTGG       ATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATGCTCCCAGAAGGGCACGAAGGTC       TCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAGCTGCACAGAGATAGACCCCTGTGCAGA       CGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGATGACAGGCCCGGGCAAGCACAAGTGTG       AGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAGCCGGAGCAGCTGCCCATTGACCGCTGC       TTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACCTCCACTTCCAGGATACCACTGT       TGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACCTTTGACAAAGCCAGAGAGGCCT       GTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTCTCCTATGCCCAGAAGGCCAAGTACCAC       CTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTACCCCACAGCCTTCGCCTCCCAGAACTG       TGGCTCTGGTGTGGTTGGGATAGTGGACTATGGACCTAGACCCAACAAGAGTGAAATGTGGGATGTCT       TCTGCTATCGGATGAAAGATGTGAACTGCACCTGCAAGGTGGGCTATGTGGGAGATGGCTTCTCATGC       AGTGGGAACCTGCTGCAGGTCCTGATGTCCTTCCCCTCACTCACAAACTTCCTGACGGAAGTGCTGGC       CTATTCCAACAGCTCAGCTCGAGGCCGTGCATTTCTAGAACACCTGACTGACCTGTCCATCCGCGGCA       CCCTCTTTGTGCCACAGAACAGTGGGCTGGGGGAGAATGAGACCTTGTCTGGGCGGGACATCGAGCAC       CACCTCGCCAATGTCAGCATGTTTTTCTACAATGACCTTGTCAATGGCACCACCCTGCAAACGAGGCT       GGGAAGCAAGCTGCTCATCACTGCCAGCCAGGACCCACTCCAACCGACGGAGACCAGGTTTGTTGATG       GAAGAGCCATTCTGCAGTGGGACATCTTTGCCTCCAATGGGATCATTCATGTCATTTCCAGGCCTTTA       AAAGCACCCCCTGCCCCCGTGACCTTGACCCACACTGGCTTGGGAGCAGGGATCTTCTTTGCCATCAT       CCTGGTGACTGGGGCTGTTGCCTTGGCTGCTTACTCCTACTTTCGGATAAACCGGAGAACAATCGGCT       TCCAGCATTTTGAGTCGGAAGAGGACATTAATGTTGCAGCTCTTGGCAAGCAGCAGCCTGAGAATATC       TCGAACCCCTTGTATGAGAGCACAACCTCAGCTCCCCCAGAACCTTCCTACGACCCCTTCACGGACTC       TGAAGAACGGCAGCTTGAGGGCAATGACCCCTTGAGGACACTG TGA   GGGCCTGGACGGGAGATGCCAC           CCATCACTCACTGCCACCTGGGCCATCAACTGTGAATTCTCAGCACCAGTTGCCTTTTAGGAACGTAP           AGTCCTTTAAGCACTCAGAAGCCATACCTCATCTCTCTGGCTGATCTGGGGGTTGTTTCTGTGGGTGA           GAGATGTGTTGCTGTGCCCACCCAGTACAGCTTCCTCCTCTGACCCTTTGGCTCTTCTTCCTTTGTAC           TCTTCAGCTGGCACCTGCTCCATTCTGCCCTACATGATGGGTAACTGTGATCTTTCTTCCCTGTTTGT           TAGATTGTAAGCCTCCGTCTTTGTATCCCAGCCCCTAGCCCAGTGCCTGACACAGGAACTGTGCACAA           TAAAGGTTTATGGAACAGAAACAAAGTCAACAGAAAAAAAAAAA                                                   NOV9x, CG50736-23   SEQ ID NO: 254   1510 aa   MW at 164274.3kD               Protein Sequence                     MDQDEKSFWLSQSNIPALIKYHMLLGTYRVADLQTLSSSDMLATSLQGNFLHLAKVDGNITIEGASIV           DGDNAATNGVIHIINKVLVPQRRLTGSLPNLLMRLEQMPDYSIFRGYIIQYNLANAIEAADAYTVFAP       NNNAIENYIREKKVLSLEEDVLRYHVVLEEKLLKNDLHNGMHRETMLGFSYFLSFFLHNDQLYVNEAP       INYTNVATDKGVIHGLGKVLEIQKNRCDNNDTTIIRGRCRTCSSELTCPFGTKSLGNEKRRCIYTSYF       MGRRTLFIGCQPKCVRTVITRECCAGFFGPQCQPCPGNAQNVCFGNGICLDGVNGTGVCECGEGFSGT       ACETCTEGKYGIHCDQACSCVHGRCNQGPLGDGSCDCDVGWRGVHCDNATTEDNCNGTCHTSANCLTN       SDGTASCKCAAGFQGNGTICTAINACEISNGGCSAKADCKRTTPGRRVCTCKAGYTGDGIVCLEINPC       LENHGGCDKNAECTQTGPNQAACNCLPAYTGDGKVCTLINVCLTKNGGCSEFAICNHTGQVERTCTCK       PNYIGDGFTCRGSIYQELPKNPKTSQYFFQLQEHFVKDLVGPGPFTVFAPLSAAFDEEARVKDWDKYG       LMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVSQSTVYINNKAKIISSDIISTNGIVHIID       KLLSPKNLLITPKDNSGRILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHA       LPAEQQDFLFNQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNG       QTCRIVQRELLFDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCL       YNLPFKRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFN       GTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATC       KENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCAD       GLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTV       GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNC       GSGVVGIVDYGPRPNKSEMWDVFCYRMKDVNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNFLTEVLA       YSNSSARGRAFLEHLTDLSIRGTLFVPQNSGLGENETLSGRDIEHHLANVSMFFYNDLVNGTTLQTRL       GSKLLITASQDPLQPTETRFVDGRAILQWDIFASNGIIHVISRPLKAPPAPVTLTHTGLGAGIFFAII       LVTGAVALAAYSYFRINPRTIGFQHFESEEDINVAALGKQQPENISNPLYESTTSAPPEPSYDPFTDS       EERQLEGNDPLRTL                                             NOV9y, CG50736-24   SEQ ID NO: 255   7670 bp               DNA Sequence   ORF Start: ATG at 8   ORF Stop: TGA at 7661                   TTTCCTC   ATG ATGCTACAACATTTAGTAATTTTTTGTCTTGGATTGGTTGTACAAAATTTCTGCTCCC       CAGCTGAAACCACAGGGCAGGCAAGAAGATGTGATAGGAAGTCTCTTCTTACAATTAGGACCGAGTGC       CGATCCTGCGCTCTCAACCTTGGAGTCAAGTGCCCGGATGGTTACACCATGATTACCAGTGGCTCTGT       AGGGGTTCGAGATTGCAGGTACACCTTTGAGGTCAGAACATACTCTCTGTCTCTCCCCGGATGCCGCC       ATATTTGTAGGAAGGACTATCTCCAACCTCGGTGTTGTCCTGGCCGCTGGGGCCCAGACTGTATAGAG       TGCCCAGGTGGAGCGGGGTCACCCTGCAATGGCAGAGGCAGTTGTGCTGAAGGCATGGAAGGAAATGG       AACCTGCTCCTGCCAAGAAGGGTTTGGTGGAACAGCCTGTGAAACCTGTGCTGACGACAACTTATTTG       GACCCAGCTGTTCATCAGTGTGCAACTGTGTGCATGGGGTGTGCAACAGTGGACTAGATGGCGATGGA       ACCTGTGAGTGCTACTCTGCGTACACTGGCCCCAAGTGTGACAAGCCCATCCCTGAATGTGCAGCCTT       GCTCTGCCCAGAAAATTCCAGATGTTCGCCTTCCACTGAAGATGAAAACAAACTGGAATGCAAATGCC       TTCCCAATTACCGAGGCGATGGCAAATACTGCGACCCCATCAATCCATGTTTACGAAAAATCTGCCAC       CCTCATGCTCATTGTACGTACCTGGGACCAAATCGGCACAGTTGTACATGCCAAGAAGGCTACCGTGG       GGATGGCCAAGTGTGCTTGCCTGTGGACCCCTGCCAAATTAACTTTGGAAACTGCCCTACAAAGTCTA       CAGTGTGCAAATATGATGGGCCTGGACAGTCTCACTGCGAGTGTAAGGAGCATTACCAGAATTTCGTA       CCTGGAGTGGGGTGCAGTATGACTGATATATGTAAATCAGATAACCCGTGTCATAGGAATGCAAATTG       CACCACCGTCGCACCAGGCCGAACTGAATGCATTTGCCAGAAAGGTTACGTGGGTGATGGCTTAACGT       GTTATGGAAACATTATGGAGCGACTCAGAGAATTAAATACTGAACCCAGAGGAAAATGGCAAGGAAGG       CTGACCTCTTTCATCTCACTCCTAGACAAAGCTTATGCCTGGCCACTGAGTAAGCTGGGACCCTTCAC       GGTGCTGTTACCTACAGACAAGGGACTGAAAGGATTCAATGTAAATGAGCTTTTGGTGGATAATAAAG       CTGCTCAATACTTTGTGAAACTCCACATAATTGCTGGTCAGATGAACATCGAATATATGAATAACACA       GACATGTTCTACACCTTGACTGGAAAGTCGGGGGAAATCTTCAACAGCGATAAGGACAATCAAATAAA       GCTTAAACTCCATGGAGGCAAAAAGAAGGTAAAAATTATACAAGGGGACATCATTGCTTCCAATGGGC       TTCTGCACATCCTTGACAGAGCCATGGACAAGTTAGAACACACATTTGAGAGCAACAATGAGCAAACC       ATAATGACAATGCTACAACCAAGGTACAGCAAGTTCAGATCTTTGTTAGAGGAAACCAATTTGGGACA       TGCCTTAGATGAGGATGGAGTTGGTGGACCATACACCATTTTTGTTCCAAATAATGAAGCATTGAATA       ACATGAAGGACGGCACTCTCGATTACCTCCTTTCTCCAGAGGGATCTCGGAAGCTTCTGGAACTCGTC       AGATACCACATTGTCCCATTTACCCAGCTTGAAGTGGCCACTCTCATCTCCACCCCTCACATCAGGAG       CATGGCCAACCAGCTCATACAGTTCAACACCACCGACAATGGACAGATTCTGGCAAATGATGTGGCAA       TGGAAGAAATTGAGATCACTGCCAAAAATGGCCGAATTTACACACTGACAGGAGTTCTCATTCCTCCC       TCCATTGTCCCGATTCTGCCCCATCGATGTGATGAAACAAAGAGAGAGATGAAACTGGGCACTTGTGT       GAGCTGTTCTCTGGTGTACTGGAGCAGATGTCCTGCTAACTCTGAGCCCACAGCACTCTTCACACACA       GATGTGTCTACAGTGGCAGGTTTGGGAGCCTGAAGAGCGGCTGTGCCCGGTACTGCAATGCCACTGTG       AAGATTCCAAAGTGCTGCAAAGGCTTCTATGGACCTGACTGCAACCAGTGTCCAGGAGGCTTCTCAAA       TCCATGCTCAGGAAATGGACAGTGTGCAGATAGCCTCGGCGGCAACGGGACATGCATTTGTGAGGAGG       GCTTCCAAGGCTCCCAGTGTCAGTTCTGCTCTGATCCCAATAAATACGGACCTCGGTGTAACAAAAAA       TGCCTGTGCGTTCACGGAACATGCAATAACAGGATAGACAGCGATGGGGCCTGCCTCACTGGCACATG       CAGAGACGGCTCTGCCGGGAGACTCTGTGATAAGCAGACCTCAGCCTGTGGGCCCTATGTGCAGTTCT       GTCACATCCACGCCACCTGTGAATACAGCAATGGGACAGCCAGTTGTATTTGCAAAGCAGGATATGAA       GGAGATGGAACTCTGTGTTCTGAGATGGACCCTTGCACAGGACTAACTCCAGGAGGCTGTAGCCGCAA       TGCAGAATGCATCAAAACTGGCACGGGCACCCACACCTGCGTGTGTCAGCAGGGTTGGACAGGGAATG       GGAGAGACTGCTCGGAGATCAACAACTGCCTGCTGCCCAGTGCAGGCGGCTGCCACGACAACGCATCC       TGTTTGTATGTGGGTCCCGGGCAGAATGAGTGTGAGTGCAAGAAAGGATTTCGAGGAAATGGGATTGA       CTGTGAACCAATAACTTCATGCTTGGAACAAACCGGGAAATGTCATCCATTGGCAAGCTGTCAATCTA       CTTCGTCTGGTGTCTGGAGCTGTGTTTGTCAAGAGGGCTATGAAGGAGATGGCTTTCTGTGCTATGGA       AACGCAGCAGTGGAATTGTCATTTCTCTCCGAAGCAGCTATATTTAACCGATGGATAAATAATGCTTC       TCTACAACCCACACTGTCAGCCACCTCAAACCTCACTGTCCTCGTGCCTTCCCAACAAGCTACTGAGG       ACATGGACCAGGATGAGAAAAGCTTCTGGTTGTCACAGAGCAATATTCCAGCCCTAATAAAGTACCAT       ATGCTACTAGGCACATACAGAGTGGCAGATCTGCAGACCCTGTCTTCTTCTGACATGTTGGCAACATC       TTTGCAGGGCAACTTCCTTCACTTGGCAAAGGTGGATGGGAATATCACAATTGAAGGGGCCTCCATTG       TCGATGGGGACAATGCAGCCACAAATGGAGTGATACACATCATCAACAAGGTGCTGGTCCCACAAAGA       CGTCTAACTGGCTCCTTACCAAACCTGCTCATGCGGCTGGAACAGATGCCTGACTATCCCATCTTCCG       GGGCTACATCATTCAATATAATCTGGCGAATGCAATTGAGGCTGCCGATGCCTACACAGTGTTTGCTC       CAAACAACAATGCCATCGAGAATTACATCAGGGAGAAGAAAGTCTTGTCTCTAGAGGAGGACGTCCTC       CGGTATCATGTGGTCCTGGAGGAGAAACTCCTGAAGAATGACCTGCACAATGGCATGCATCGTGAGAC       CATGCTGGGTTTCTCCTATTTCCTTAGCTTCTTTCTCCATAATGACCAGCTCTATGTAAATGAGGCTC       CAATAAACTACACCAATGTAGCCACTGATAAGGGAGTGATCCATGGCTTGGGAAAAGTTCTGGAAATT       CAGAAGAACAGATGTGATAATAATGCCACTACTATTATACGAGGAAGATGTAGGACATGCTCCTCAGA       GCTGACCTGCCCATTCGGAACTAAATCTCTAGGTAATGAGAAGAGGAGATGCATCTATACCTCCTATT       TCATGGGAAGACGAACCCTGTTTATTGGGTGCCAGCCAAAATGTGTGAGAACCGTCATTACGAGAGAA       TGCTGTGCCGGCTTCTTTGGCCCCCAATGCCAGCCCTGTCCAGGGAATGCCCAGAATGTCTGCTTTGG       TAATGGCATCTGTTTGGATGGAGTGAATGGCACAGGTGTGTGTGAGTGTGGGGAGGGCTTCAGCGGCA       CAGCCTGCGAGACCTGCACCGAGGGCAAGTACGGCATCCACTGTGACCAAGCATGTTCTTGTGTCCAT       GGGAGATGCAACCAAGGACCCTTGGGAGATGGCTCCTGTGACTGTGATGTTGGCTGGCGAGGAGTGCA       TTGTGACAATGCAACCACAGAAGACAACTGCAATGGGACATGCCATACCAGCGCCAACTGCCTCACCA       ACTCAGATGGTACAGCTTCATGCAAGTGTGCAGCAGGATTCCAAGGAAACGGGACCATCTGCACAGCA       ATCAATGCCTGTGAGATCAGCAATGGAGGTTGCTCTGCCAAGGCTGACTGTAAGAGAACCACCCCAGG       AAGGCGAGTGTGCACGTGCAAAGCAGGCTACACGGGTGATGGCATTGTGTGCCTGGAAATCAACCCGT       GTTTGGAGAACCATGGTGGCTGTGACAAGAATGCGGAGTGCACACAGACAGGACCCAACCAGGCTGCC       TGTAACTGTTTGCCAGCATACACTGGAGATGGAAAGGTCTGCACACTCATCAATGTCTGCTTAACTAA       AAATGGCGGCTGTAGTGAATTTGCCATCTGCAACCACACTGGGCAAGTAGAAAGGACTTGTACTTGCA       AGCCAAACTACATTGGAGATGGATTTACCTGCCGCGGCAGCATTTATCAGGAGCTTCCCAAGAACCCG       AAAACTTCCCAGTATTTCTTCCAGTTGCAGGAGCATTTCGTGAAAGATCTGGTCGGCCCAGGCCCCTT       CACTGTTTTTGCACCTTTATCTGCAGCCTTTGATGAGGAAGCTCGGGTTAAAGACTGGGACAAATACG       GTTTAATGCCCCAGGTTCTTCGGTACCATGTGGTCGCCTGCCACCAGCTGCTTCTGGAAAACCTGAAA       TTGATCTCAAATGCTACTTCCCTCCAAGGAGAGCCAATAGTCATCTCCGTCTCTCAGAGCACGGTGTA       TATAAATAATAAGGCTAAGATCATATCCAGTGATATCATCAGTACTAATGGGATTGTTCATATCATAG       ACAAATTGCTATCTCCCAAAAATTTGCTTATCACTCCCAAAGACAACTCTGGAAGAATTCTGCAAAAT       CTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTTAATACAGGACTCAGGTTTGCT       GAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGCCCACCGACCAAGCCCTCCATG       CCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAGGACAAGCTGAAGGAGTATTTG       AAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCCCACATCCACTGCCTGGAAGAC       CCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACATCGGTGACCTCTTTCTGAATG       GCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGTGTGGCCTACGGCATTGACTGT       CTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTACTTTCGATGCCTCGGGGGAGTG       TGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAAAGGGTGTGAAGCAGAAGTGTC       TCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGGTGCAGCCTGGTGATACAGATC       CCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCCTGCCCTGGAGGACCAGATGCCCCGTG       TAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCACCGGAGAGTGTAAATGCAACACCGGCTTCA       ATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTTGGGCCTGATTGTCTGCCCTGTGGCTGCTCA       GACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAGTGCCTCTGTGAAACGGGGTGGACAGG       CCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTACGCCTCCTTGTTCTGCTCATGCCACCT       GTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAGGTGACGGAATCACATGCACAGTTGTG       GATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATGCTCCCAGAAGGGCACGAAGGT       CTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAGCTGCACAGAGATAGACCCCTGTGCAG       ACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGATGACAGGCCCGGGCAAGCACAAGTGT       GAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAGCCGGAGCAGCTGCCCATTGACCGCTG       CTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACCTCCACTTCCAGGATACCACTG       TTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACCTTTGACAAAGCCAGAGAGGCC       TGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTCTCCTATGCCCAGAAGGCCAAGTACCA       CCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTACCCCACAGCCTTCGCCTCCCAGAACT       GTGGCTCTGGTGTGGTTGGGATAGTGGACTATGGACCTAGACCCAACAAGAGTGAAATGTGGGATGTC       TTCTGCTATCGGATGAAAGATGTGAACTGCACCTGCAAGGTGGGCTATGTGGGAGATGGCTTCTCATG       CAGTGGGAACCTGCTGCAGGTCCTGATGTCCTTCCCCTCACTCACAAACTTCCTGACGGAAGTGCTGG       CCTATTCCAACAGCTCAGCTCGAGGCCGTGCATTTCTAGAACACCTGACTGACCTGTCCATCCGCGGC       ACCCTCTTTGTGCCACAGAACAGTGGGCTGGGGGAGAATGAGACCTTGTCTGGGCGGGACATCGAGCA       CCACCTCGCCAATGTCAGCATGTTTTTCTACAATGACCTTGTCAATGGCACCACCCTGCAAACGAGGC       TGGGAAGCAAGCTGCTCATCACTGCCAGCCAGGACCCACTCCAACCGACGGAGACCAGGTTTGTTGAT       GGAAGAGCCATTCTGCAGTGGGACATCTTTGCCTCCAATGGGATCATTCATGTCATTTCCAGGCCTTT       AAAAGCACCCCCTGCCCCCGTGACCTTGACCCACACTGGCTTGGGAGCAGGGATCTTCTTTGCCATCA       TCCTGGTGACTGGGGCTGTTGCCTTGGCTGCTTACTCCTACTTTCGGATAAACCGGAGAACAATCGGC       TTCCAGCATTTTGAGTCGGAAGAGGACATTAATGTTGCAGCTCTTGGCAAGCAGCAGCCTGAGAATAT       CTCGAACCCCTTGTATGAGAGCACAACCTCAGCTCCCCCAGAACCTTCCTACGACCCCTTCACGGACT       CTGAAGAACGGCAGCTTGAGGGCAATGACCCCTTGAGGACACTG TGA   GGGCCTG                                                   NOV9y, CG50736-24   SEQ ID NO: 256   2551 aa   MW at 276991.0kD               Protein Sequence                     MMLQHLVIFCLGLVVQNFCSPAETTGQARRCDRKSLLTIRTECRSCALNLGVKCPDGYTMITSGSVGV           RDCRYTFEVRTYSLSLPGCRHICRKDYLQPRCCPGRWGPDCIECPGGAGSPCNGRGSCAEGMEGNGTC       SCQEGFGGTACETCADDNLFGPSCSSVCNCVHGVCNSGLDGDGTCECYSAYTGPKCDKPIPECAALLC       PENSRCSPSTEDENKLECKCLPNYRGDGKYCDPINPCLRKICHPHAHCTYLGPNRHSCTCQEGYRGDG       QVCLPVDPCQINFGNCPTKSTVCKYDGPGQSHCECKEHYQNFVPGVGCSMTDICKSDNPCHRNANCTT       VAPGRTECICQKGYVGDGLTCYGNIMERLRELNTEPRGKWQGRLTSFISLLDKAYAWPLSKLGPFTVL       LPTDKGLKGFNVNELLVDNKAAQYFVKLHIIAGQMNIEYMNNTDMFYTLTGKSGEIFNSDKDNQIKLK       LHGGKKKVKIIQGDIIASNGLLHILDRAMDKLEHTFESNNEQTIMTMLQPRYSKFRSLLEETNLGHAL       DEDGVGGPYTIFVPNNEALNNMKDGTLDYLLSPEGSRKLLELVRYHIVPFTQLEVATLISTPHIRSMA       NQLIQFNTTDNGQILANDVAMEEIEITAKNGRIYTLTGVLIPPSIVPILPHRCDETKREMKLGTCVSC       SLVYWSRCPANSEPTALFTHRCVYSGRFGSLKSGCARYCNATVKIPKCCKGFYGPDCNQCPGGFSNPC       SGNGQCADSLGGNGTCICEEGFQGSQCQFCSDPNKYGPRCNKKCLCVHGTCNNRIDSDGACLTGTCRD       GSAGRLCDKQTSACGPYVQFCHIHATCEYSNGTASCICKAGYEGDGTLCSEMDPCTGLTPGGCSRNAE       CIKTGTGTHTCVCQQGWTGNGRDCSEINNCLLPSAGGCHDNASCLYVGPGQNECECKKGFRGNGIDCE       PITSCLEQTGKCHPLASCQSTSSGVWSCVCQEGYEGDGFLCYGNAAVELSFLSEAAIFNRWINNASLQ       PTLSATSNLTVLVPSQQATEDMDQDEKSFWLSQSNIPALIKYHMLLGTYRVADLQTLSSSDMLATSLQ       GNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVPQRRLTGSLPNLLMRLEQMPDYPIFRGY       IIQYNLANAIEAADAYTVFAPNNNAIENYIREKKVLSLEEDVLRYHVVLEEKLLKNDLHNGMHRETML       GFSYFLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVLEIQKNRCDNNATTIIRGRCRTCSSELT       CPFGTKSLGNEKRRCIYTSYFMGRRTLFIGCQPKCVRTVITRECCAGFFGPQCQPCPGNAQNVCFGNG       ICLDGVNGTGVCECGEGFSGTACETCTEGKYGIHCDQACSCVHGRCNQGPLGDGSCDCDVGWRGVHCD       NATTEDNCNGTCHTSANCLTNSDGTASCKCAAGFQGNGTICTAINACEISNGGCSAKADCKRTTPGRR       VCTCKAGYTGDGIVCLEINPCLENHGGCDKNAECTQTGPNQAACNCLPAYTGDGKVCTLINVCLTKNG       GCSEFAICNHTGQVERTCTCKPNYIGDGFTCRGSIYQELPKIJPKTSQYFFQLQEHFVDLVGPGPFTV       FAPLSAAFDEEARVKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVSQSTVYIN       NKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGYIKFSNLIQDSGLLSV       ITDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQ       GSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGS       CVNTPSCPRWSKPKGVKQKCLYNLPFKRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNN       RGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPS       CDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSC       SCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLPIDRCLQ       DNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAXYHLC       SAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCYRMKDVNCTCKVGYVGDGFSCSG       NLLQVLMSFPSLTNFLTEVLAYSNSSARGRAFLEHLTDLSIRGTLFVPQNSGLGENETLSGRDIEHHL       ANVSMFFYNDLVNGTTLQTRLGSKLLITASQDPLQPTETRFVDGRAILQWDIFASNGIIHVISRPLKA       PPAPVTLTRTGLGAGIFFAIILVTGAVALAAYSYFRINRRTIGFQHFESEEDINVAALGKQQPENISN       PLYESTTSAPPEPSYDPFTDSEERQLEGNDPLRTL                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 9B.  
               TABLE 9B                       Comparison of the NOV9 protein sequences.                                            NOV9a   ------------------------------------------------------------           NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   MERQETGNSKTRYHATAIVQAKHDKGLNKNGTSGDEEQKIKVGDRDRENKGFDGLLDVWN       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   ------------------------------------------------------------               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   TLNFIHPCFAVCNCVHGVCNSGLDGDGTCECYSAYTGPKCDKLTENFHTSHLTLWPVHDS       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   ------------------------------------------------------------               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   KHWGSLRHQNMNGTCSSGGGKGDPDVYQNGLIFHGGGTSGGLSSSRNRRSSVKRPEKWKG       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   -----------------------------------------------MMLQHLVIFCLGL               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   DDRDGGGKEGQQRRRADTESSLQRGHIKTPLPHRQGEARITETTGNCVSAGMTGTNANHT       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   VVQNFCSPAETTGQARRCDRKSLLTIRTECRSCALNLGVKCPDGYTMITSGSVGVRDCRY               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   KVHPTVQSLTEYDSFQTHSTSRLKEFEKQQVKERFSDPPLMQAIKPSHEKYPPYAQRKGT       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   TFEVRTYSLSLPGCRRICRKDYLQPRCCPGRWGPDCIECPGGAGSPCNGRGSCAEGMEGN               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   SLSPKTQGHGDDEQALLSFLHSITLSLYLYPTTFFHDSPVFIKPGIKTLRLNHFFGSSFP       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   GTCSCQEGFGGTACETCADDNLFGPSCSSVCNCVHGVCNSGLDGDGTCECYSAYTGPKCD               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   YEGSSVIXXMGIEVWKNWCQNADTLAAAPAPSLNVQPCSAQKIPDVRLPLKMKTNWNANA       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   KPIPECAALLCPENSRCSPSTEDENKLECKCLPNYRGDGKYCDPINPCLRKTCHPHAHCT               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   FPITEAMANTATPSIHVYEKSATLMLIVRTWDQIGTVVHAKKATVGMAKCACLWTPAKLT       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   YLGPNPBSCTCQEGYRGDGQVCLPVDPCQINFGNCPTKSTVCKYDGPGQSHCECKEHYQN               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   LETALQSLQCANMMGLDRCICQKGYVGDGLTCYGNIMERLRELNTEPRGKWQGRLTSFIS       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   FVPGVGCSMTDICKSDNPCHRNANCTTVAPGRTECICQKGYVGDGLTCYGNIMERLRELN               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   LLESIQIVSVQLSEFSQREPTCVNTKSIASNLEGPLVPLSNHYPLQVNELLVDNKAAQYF       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   TEPRGKWQGRLTSFISLLDKAYAWPLSKLGPFTVLLPTDKGLKGFNVNELLVDNKAAQYF               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   VKLHIIAGQMNIEYMNNTDMFYTLTGKSGEIFNSDKDNQIKLKLHGGKKKVKIIQGDIIA       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   VKLHIIAGQMNIEYMNNTDMFYTLTGKSGEIFNSDKDNQIKLKLHGGKKKVKIIQGDIIA               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   SNGLLHILDRAMDKLEPTF-------------------ESNNEETNLGHALDEDGVGGPY       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   SNGLLHILDRAMDKLEHTFESNNEQTIMTMLQPRYSKFRSLLEETNLGHALDEDGVGGPY               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   TIFVPNNEALNNMKDGTLDYLLSP------------------ELEVATLISTPHIRSMAN       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   TIFVPNNEALNNMKDGTLDYLLSPEGSRKLLELVRYHIVPFTQLEVATLISTPHIRSMAN               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   QLIQFNTTDNGQILANDVAMEEIEITAKNGRIYTLTGVLIPPSIVPILPHRCDETKREMK       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   QLIQFNTTDNGQILANDVAMEEIEITAKNGRIYTLTGVLIPPSIVPILPHRCDETKREMK               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   LGTCVSCSLVYWSRCPANSEPTALFTHRCVYSGRFGSLKSGCARYC--------------       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   LGTCVSCSLVYWSRCPANSEPTALFTHRCVYSGRFGSLKSGCARYCNATVKIPKCCKGFY               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   ---------------NATVKCADSLGGNGTCICEEGFQGSQCQFCSDPNKYGPRCNKKCL       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   GPDCNQCPGGFSNPCSGNGQCADSLGGNGTCICEEGFQGSQCQFCSDPNKYGPRCNKKCL               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   CVHGTCNNRIDSDGACLTGTCRDGSAGRLCDKQTSACGPYVQFCHIHATCEYSNGTASCI       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   CVHGTCNNRIDSDGACLTGTCRDGSAGRLCDKQTSACGPYVQFCHIHATCEYSNGTASCI               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   CKAGYEGDGTLCSEMDPCTGLTPGGCSRNAECIKTGTGTHTCVCQQGWTGNGRDCSEINN       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   CKAGYEGDGTLCSEMDPCTGLTPGGCSRNAECIKTGTGTHTCVCQQGWTGNGRDCSEINN               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   CLLPSAGGCHDNASCLYVGPGQNECECKKGFRGNGIDCEPITSCLEQTGKCHPLASCQST       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   CLLPSAGGCHDNASCLYVGPGQNECECKKGFRGNGIDCEPITSCLEQTGKCHPLASCQST               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   SSGVWSCVCQEGYEGDGFLCYGNAAVELSFLSEAAIFNRWINNASLQPTLSATSNLTVLV       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ------------------------------------------------------------       NOV9x   ------------------------------------------------------------       NOV9y   SSGVWSCVCQEGYEGDGFLCYGNAAVELSFLSEAAIFNRWINNASLQPTLSATSNLTVLV               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   PSQQATEDMDQDEKSFWLSQSNIPALIKYHMLLGTYRVADLQTLSSSDMLATSLQGNFLH       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   --------MDQDEKSFWLSQSNIPALIKYHNLLGTYRVADLQTLSSSDMLATSLQGNFLH       NOV9x   --------MDQDEKSFWLSQSNIPALIKYHMLLGTYRVADLQTLSSSDMLATSLQGNFLH       NOV9y   PSQQATEDMDQDEKSFWLSQSNIPALIKYHMLLGTYRVADLQTLSSSDMLATSLQGNFLH               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   LAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVPQRRLTGSLPNLLMRLEQMPDYSIF       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   LAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVPQRRLTGSLPNLLMRLEQMPDYSIF       NOV9x   LAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVPQRRLTGSLPNLLMRLEQMPDYSIF       NOV9y   LAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVPQRRLTGSLPNLLMRLEQMPDYPIF               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   RGYIIQYNLANAIEAADAYTVFAPNNNAIENYIREKKVLSLEEDVLRYHVVLEEKLLKND       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   RGYIIQYNLANAIEAADAYTVFAPNNNAIENYIREKKVLSLEEDVLRYHVVLEEKLLKND       NOV9x   RGYIIQYNLANAIEAADAYTVFAPNNNAIENYIREKKVLSLEEDVLRYHVVLEEKLLKND       NOV9y   RGYIIQYNLANAIEAADAYTVFAPNNNAIENYIREKKVLSLEEDVLRYHVVLEEKLLKND               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   LHNGMHRETMLGFSYFLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVLEIQKNRCD       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   LHNGMHRETMLGFSYFLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVLEIQKNRCD       NOV9x   LHNGMHRETMLGFSYFLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVLEIQKNRCD       NOV9y   LHNGMHRETMLGFSYFLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVLEIQKNRCD               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   NNDTTIIRGRCRTCSSELTCPFGTKSLGNEKRRCIYTSYFMGRRTLFIGCQPKCVRTVIT       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   NNDTTIIRGRCRTCSSELTCPFGTKSLGNEKRRCIYTSYFMGRRTLFIGCQPKCVRTVIT       NOV9x   NNDTTIIRGRCRTCSSELTCPFGTKSLGNEKRRCIYTSYFMGRRTLFIGCQPKCVRTVIT       NOV9y   NNATTIIRGRCRTCSSELTCPFGTKSLGNEKRRCIYTSYFMGRRTLFIGCQPKCVRTVIT               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   RECCAGFFGPQCQPCPGNAQNVCFGNGICLDGVNGTGVCECGEGFSGTACETCTEGKYGI       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   RECCAGFFGPQCQPCPGNAQNVCFGNGICLDGVNGTGVCECGEGFSGTACETCTEGKYGI       NOV9x   RECCAGFFGPQCQPCPGNAQNVCFGNGICLDGVNGTGVCECGEGFSGTACETCTEGKYGI       NOV9y   RECCAGFFGPQCQPCPGNAQNVCFGNGICLDGVNGTGVCECGEGFSGTACETCTEGKYGI               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   HCDQACSCVHGRCNQGPLGDGSCDCDVGWRGVHCDNATTEDNCNGTCHTSANCLTNSDGT       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   HCDQACSCVHGRCNQGPLGDGSCDCDVGWRGVHCDNATTEDNCNGTCHTSANCLTNSDGT       NOV9x   HCDQACSCVHGRCNQGPLGDGSCDCDVGWRGVHCDNATTEDNCNGTCHTSANCLTNSDGT       NOV9y   HCDQACSCVHGRCNQGPLGDGSCDCDVGWRGVHCDNATTEDNCNGTCHTSANCLTNSDGT               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   ASCKCAAGFQGNGTICTAINACEISNGGCSAXADCKRTTPGRRVCTCKAGYTGDGIVCLE       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   ASCKCAAGFQGNGTICTAINACEISNGGCSAXADCKRTTPGRRVCTCKAGYTGDGIVCLE       NOV9x   ASCKCAAGFQGNGTICTAINACEISNGGCSAKADCKRTTPGRRVCTCKAGYTGDGIVCLE       NOV9y   ASCKCAAGFQGNGTICTAINACEISNGGCSAKADCKRTTPGRRVCTCKAGYTGDGIVCLE               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   INPCLENHGGCDKNAECTQTGPNQAACNCLPAYTGDGKVCTLINVCLTKNGGCSEFAICN       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   INPCLENHGGCDKNAECTQTGPNQAACNCLPAYTGDGKVCTLINVCLTKNGGCGEFAICN       NOV9x   INPCLENHGGCDKNAECTQTGPNQAACNCLPAYTGDGKVCTLINVCLTKNGGCGEFAICN       NOV9y   INPCLENHGGCDKNAECTQTGPNQAACNCLPAYTGDGKVCTLINVCLTKNGGCSEFAICN               NOV9a   ------------------------------------------------------------       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ----MEARKELESLPPFCLNSLHSIILTTKLTSQSLGGPRGVEERNEDREAKWHIAAKDS       NOV9f   ----MEARKELESLPPFCLNSLHSIILTTKLTSQSLGGPRGVEERMEDRRAKWHIAAKDS       NOV9g   ------------------------------------------------------------       NOV9h   ----MEARKELESLPPFCLNSLHSIILTTKLTSQSLGGPRGVEERNEDREAKWHIAAKDS       NOV9i   ----MEARKELESLPPFCLNSLHSIILTTKLTSQSLGGPRGVEERMEDRPAKWHIAAKDS       NOV9j   ------------------------------------------------------------       NOV9k   HTGQVERTCTCKPNYIGDGFTCRGSIYQELPKNPKTSQYFFQLQEHFVKDLVGPGPFTVF       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   HTGQVERTCTCKPNYIGDGFTCRGSIYQELPKNPKTSQYFFQLQEHFVKDLVGPGPFTVF       NOV9x   HTGQVERTCTCKPNYIGDGFTCRGSIYQELPKNPKTSQYFFQLQEHFVKDLVGPGPFTVF       NOV9y   HTGQVERTCTCKPNYIGDGFTCRGSIYQELFKNPKTSQYFFQLQEHFVKDLVGPGPFTVF               NOV9a   ---------------------MPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVS       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   CLWLKPSDLLLQVKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVS       NOV9f   CLWLKPSDLLLQVKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVS       NOV9g   ------------------------------------------------------------       NOV9h   CLWLKPSDLLLQVKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVS       NOV9i   CLWLKPSDLLLQVKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVS       NOV9j   ------------------------VLRYHVVACHQLLLENLKLISNATSLQGEPIVISVS       NOV9k   APLSAAFDEEARVKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVS       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   APLSAAFDEEARVKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVS       NOV9x   APLSAAFDEEARVKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVS       NOV9y   APLSAAFDEEARVKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVS               NOV9a   QSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGY       NOV9b   -------------------------------------------GSRILQNLTTLATNNGY       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   QSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGY       NOV9f   QSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGY       NOV9g   ------------------------------------------------------------       NOV9h   QSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGY       NOV9i   QSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGY       NOV9j   QSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGY       NOV9k   QSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGY       NOV9l   ---------------------------------------------RILQNLTTLATNNGY       NOV9m   ---------------------------------------------RILQNLTTLATNNGY       NOV9n   ---------------------------------------------RILQNLTTLATNNGY       NOV9o   ---------------------------------------------RILQNLTTLATNNGY       NOV9p   ---------------------------------------------RILQNLTTLATNNGY       NOV9q   ---------------------------------------------RILQNLTTLATNNGY       NOV9r   ---------------------------------------------RILQNLTTLATNNGY       NOV9s   ---------------------------------------------RILQNLTTLATNNGY       NOV9t   ---------------------------------------------RILQNLTTLATNNGY       NOV9u   ---------------------------------------------RILQNLTTLATNNGY       NOV9v   ---------------------------------------------RILQNLTTLATNNGY       NOV9w   QSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGY       NOV9x   QSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGY       NOV9y   QSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGY               NOV9a   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9b   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9f   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9g   ------------------------------------------------------------       NOV9h   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9i   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9j   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9k   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALHALPAEQQDFLFNQDNKDKLKEY       NOV9l   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9m   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9n   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9o   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9p   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9q   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9r   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9s   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9t   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9u   IKFSNLIQDSGLLSVVTDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9v   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9w   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9x   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY       NOV9y   IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAE---QQDFLFNQDNKDKLKEY               NOV9a   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9b   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9f   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9g   ---------------LPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9h   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9i   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9j   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9k   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTYRIVQRELLFD       NOV9l   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9m   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9n   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9o   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9p   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9q   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9r   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOv9s   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9t   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9u   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9v   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9w   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9x   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD       NOV9y   LKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFD               NOV9a   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9b   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9f   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9g   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9h   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9i   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9j   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9k   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9l   LGVAYGIDCLLIDPTLGGRCDTFTTFDAS-------------------GVKQKCLYNLPF       NOV9m   LGVAYGIDCLLIDPTLGGRCDTFTTFDAS-------------------GVKQKCLYNLPF       NOV9n   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9o   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9p   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9q   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9r   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9s   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQRCLYNLPF       NOV9t   LGVACGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9u   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9v   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9w   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9x   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF       NOV9y   LGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPF               NOV9a   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9b   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPVAPCNNRGVCLDQYSATGECKCNT       NOV9f   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9g   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9h   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQGE--GASSP-------LATL----KVSALI       NOV9i   KRNLEGCRERCSLVIQIP------------------------------------------       NOV9j   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9k   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9l   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9m   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9n   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9o   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDLYSATGECKCNT       NOV9p   KPNLEGCRERCSLVTQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9q   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9r   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9s   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9t   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9u   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9v   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9w   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQPR--------NSKSVCLDQYSATGECKCNT       NOV9x   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT       NOV9y   KRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNT               NOV9a   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9b   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9c   --------MCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLSAV       NOV9d   --------MCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLSAV       NOV9e   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLSAV       NOV9f   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLSAV       NOV9g   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLSAV       NOV9h   STRPPESVNATPASMGRRVRCAGRGDLGLIVCPVA-A--------------QTTDSAMMA       NOV9i   ---------SLPWRTRCPV-----------------------------------------       NOV9j   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLSAV       NOV9k   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9l   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9m   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9n   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCNDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9o   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9p   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9q   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9r   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9s   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9t   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9u   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9v   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9w   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9x   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV       NOV9y   GFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAV               NOV9a   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9b   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9c   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9d   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9e   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9f   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9g   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9h   SRAPGSASVKRG------------GQAPRVTLRQFCLQCVRLLVLLMPPVRRTTRVSVTW       NOV9i   ------------------------------------------------------------       NOV9j   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9k   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9l   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9m   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9n   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9o   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9p   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9q   CTPPCSAHATCKENNTCECYLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9r   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCNC       NOV9s   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9t   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9u   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9v   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9w   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9x   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC       NOV9y   CTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSC               NOV9a   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9b   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCGPEQLP       NOV9c   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9d   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9e   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9f   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9g   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9h   IMKVT---ESHAQLWISANRTTGAVQRWPDAPRPAR-RSPAAARRDTKGTGTAAQR----       NOV9i   ------------------------------------------------------------       NOV9j   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9k   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9l   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9m   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9n   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9o   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9p   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKNTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9q   QKGYKGDGHSCTEIDPCADGLNGGCHEHATRKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9r   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9s   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9t   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKNTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9u   QKGYKGDGHSCTETDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9v   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSRYVGDGLNCEPEQLP       NOV9w   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9x   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP       NOV9y   QKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLP               NOV9a   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9b   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9c   IDRCLQDNGQCHADAKCADLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9d   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9e   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9f   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9g   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9k   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9l   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9m   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9n   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDRAREACANEAATMATY       NOV9o   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9p   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9q   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9r   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9s   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9t   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9u   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATTATY       NOV9v   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9w   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9x   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY       NOV9y   IDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATY               NOV9a   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9b   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9c   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9d   NQLSYAQKREEK------------------------------------------------       NOV9e   NQLSYAQKTWYSFTKE--------------------------------------------       NOV9f   NQLSYAQKTWYSFTKE--------------------------------------------       NOV9g   NQLSYAQKTWYSFTKE--------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   NQLSYAQKTWYSFTKE--------------------------------------------       NOV9k   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9l   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9m   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9n   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9o   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9p   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9q   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9r   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9s   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSSVVGIVDYGPRPNKSEMWDVFCY       NOV9t   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9u   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9v   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9w   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9x   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY       NOV9y   NQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCY               NOV9a   RMKDVNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNFLTEVLAYSNSSARGRAFLEHLTD       NOV9b   RP----------------------------------------------------------       NOV9c   RMKGS----------------AGLFQQLSSRPCISRTPD---------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   RMKGS----------------AGLFQQLSSRPCISRTPD---------------------       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   RMKDVNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNFLTEVLAYSNSSARGRAFLEHLTD       NOV9x   RMKDVNCTCKVGYVGDGFSCSGNLLQVLNSFPSLTNFLTEVLAYSNSSARGRAFLEHLTD       NOV9y   RMKDVNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNFLTEVLAYSNSSARGRAFLEHLTD               NOV9a   LSIRGTLFVPQNSGLGENETLSGRDIEHHLANVSMFFYNDLVNGTTLQTRVGSKLLITAS       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   ------------------------------------------------------------       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   LSIRGTLFVPQNSGLGENETLSGRDIEHHLANVSMFFYNDLVNGTTLQTRVGSKLLITAS       NOV9x   LSIRGTLFVPQNSGLGENETLSGRDIEHHLANVSMFFYNDLVNGTTLQTRLGSKLLITAS       NOV9y   LSIRGTLFVPQNSGLGENETLSGRDIEHHLANVSMFFYNDLVNGTTLQTRLGSKLLITAS               NOV9a   QDPLQPTETRFVDGRAILQWDIFASNGIIHVISRPLKAPPAPVTLTHTGLGAGIFFAIIL       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   ------------------------------------------------------------       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   QDPLQPTETRFVDGRAILQWDIFASNGIIHVISRPLKAPPAPVTLTHTGLGAGIFFAIIL       NOV9x   QDPLQPTETRFVDGPAILQWDIFASNGIIHVISRPLKAPPAPVTLTHTGLGAGIFFAIIL       NOV9y   QDPLQPTETRFVDGRAILQWDIFASNGIIHVISRPLKAPPAPVTLTHTGLGAGIFFAIIL               NOV9a   VTGAVALAAYSYFRINRRTIGFQHFESEEDINVAALGKQQPENISNPLYESTTSAPPEPS       NOV9b   ------------------------------------------------------------       NOV9c   ------------------------------------------------------------       NOV9d   ------------------------------------------------------------       NOV9e   ------------------------------------------------------------       NOV9f   ------------------------------------------------------------       NOV9g   ------------------------------------------------------------       NOV9h   ------------------------------------------------------------       NOV9i   ------------------------------------------------------------       NOV9j   ------------------------------------------------------------       NOV9k   ------------------------------------------------------------       NOV9l   ------------------------------------------------------------       NOV9m   ------------------------------------------------------------       NOV9n   ------------------------------------------------------------       NOV9o   ------------------------------------------------------------       NOV9p   ------------------------------------------------------------       NOV9q   ------------------------------------------------------------       NOV9r   ------------------------------------------------------------       NOV9s   ------------------------------------------------------------       NOV9t   ------------------------------------------------------------       NOV9u   ------------------------------------------------------------       NOV9v   ------------------------------------------------------------       NOV9w   VTGAVALAAYSYFRINRRTIGFQHFESEEDINVAALGKQQPENISNPLYESTTSAPPEPS       NOV9x   VTGAVALAAYSYFRINRRTIGFQHFESEEDINVAALGKQQPENISNPLYESTTSAPPEPS       NOV9y   VTGAVALAAYSYFRINRRTIGFQHFESEEDINVAALGKQQPENISNPLYESTTSAPPEPS               NOV9a   YDPFTDSEERQLEGNDPLRTL       NOV9b   ---------------------       NOV9c   ---------------------       NOV9d   ---------------------       NOV9e   ---------------------       NOV9f   ---------------------       NOV9g   ---------------------       NOV9h   ---------------------       NOV9i   ---------------------       NOV9j   ---------------------       NOV9k   ---------------------       NOV9l   ---------------------       NOV9m   ---------------------       NOV9n   ---------------------       NOV9o   ---------------------       NOV9p   ---------------------       NOV9q   ---------------------       NOV9r   ---------------------       NOV9s   ---------------------       NOV9t   ---------------------       NOV9u   ---------------------       NOV9v   ---------------------       NOV9w   YDPFTDSEERQLEGNDPLRTL       NOV9x   YDPFTDSEERQLEGNDPLRTL       NOV9y   YDPFTDSEERQLEGNDPLRTL               NOV9a   (SEQ ID NO: 208)       NOV9b   (SEQ ID NO: 210)       NOV9c   (SEQ ID NO: 212)       NOV9d   (SEQ ID NO: 214)       NOV9e   (SEQ ID NO: 216)       NOV9f   (SEQ ID NO: 218)       NOV9g   (SEQ ID NO: 220)       NOV9h   (SEQ ID NO: 222)       NOV9i   (SEQ ID NO: 224)       NOV9j   (SEQ ID NO: 226)       NOV9k   (SEQ ID NO: 228)       NOV9l   (SEQ ID NO: 230)       NOV9m   (SEQ ID NO: 232)       NOV9n   (SEQ ID NO: 234)       NOV9o   (SEQ ID NO: 236)       NOV9p   (SEQ ID NO: 238)       NOV9q   (SEQ ID NO: 240)       NOV9r   (SEQ ID NO: 242)       NOV9s   (SEQ ID NO: 244)       NOV9t   (SEQ ID NO: 246)       NOV9u   (SEQ ID NO: 248)       NOV9v   (SEQ ID NO: 250)       NOV9w   (SEQ ID NO: 252)       NOV9x   (SEQ ID NO: 254)       NOV9y   (SEQ ID NO: 256)                  
 
      Further analysis of the NOV9a protein yielded the following properties shown in Table 9C.  
               TABLE 9C                       Protein Sequence Properties NOV9a                                        SignalP analysis:   Cleavage site between residues 32 and 33       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 6; pos. chg 1; neg. chg 0           H-region:   length 11; peak value 3.91           PSG score:   −0.49                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −5.51           possible cleavage site: between 28 and 29                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 2           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 808-824               −8.33                             PERIPHERAL   Likelihood = 2.97 (at 663)                         ALOM score: −8.33 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 815           Charge difference: −1.0 C(1.5)-N(2.5)           N &gt;= C: N- terminal side will be inside                 &gt;&gt;&gt; Single TMS is located near the C-terminus       &gt;&gt;&gt; membrane topology: type Nt (cytoplasmic tail 1 to 807)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   1   Hyd Moment(75):   5.98           Hyd Moment(95):   9.18   G content:   0           D/E content:   1   S/T content:   0                         Score: −3.74       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 16 LRY|HV                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 8.7%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: found                         LL at 15           LL at 16           LL at 69           LL at 75           LL at 111           LL at 213           LL at 226           LL at 660                 checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic /Nuclear discrimination           Prediction: nuclear           Reliability: 55.5       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         30.4%: nuclear           21.7%: cytoplasmic           13.0%: mitochondrial           13.0%: Golgi            8.7%: vesicles of secretory system            8.7%: endoplasmic reticulum            4.3%: peroxisomal                 &gt;&gt; prediction for CG50736-09 is nuc (k = 23)                  
 
      A search of the NOV9a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 9D.  
               TABLE 9D                          Geneseq Results for NOV9a                                         NOV9a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               ABJ10588   Human novel protein NOV1c SEQ ID   1 . . . 897    897/897 (100%)   0.0           NO: 211 -  Homo sapiens , 897 aa.   1 . . . 897    897/897 (100%)           [WO200259315-A2, 01-AUG-2002]       ABG72514   Human 190 kDa Hyaluronan receptor   1 . . . 897   896/897 (99%)   0.0           for endocytosis (HARE) #2 -  Homo     757 . . . 1653    897/897 (99%)             sapiens , 1653 aa. [WO200286093-A2,           31-OCT-2002]       ABG72499   Human 190 kDa Hyaluronan receptor   1 . . . 897   896/897 (99%)   0.0           for endocytosis (HARE) #1 -  Homo     520 . . . 1416    897/897 (99%)             sapiens , 1416 aa. [WO200286093-A2,           31-OCT-2002]       AAM47684   Human Hyaluronic Acid Receptor for   1 . . . 897   896/897 (99%)   0.0           Endocytosis, HARE -  Homo sapiens ,   498 . . . 1394    897/897 (99%)           1394 aa. [WO200181544-A2, 01-NOV-           2001]       ABG72498   Rat 175 kDa Hyaluronan receptor for   1 . . . 886   674/887 (75%)   0.0           endocytosis (HARE) -  Rattus  sp, 1431   519 . . . 1404    758/887 (84%)           aa. [WO200286093-A2, 31-OCT-2002]                  
 
      In a BLAST search of public sequence databases, the NOV9a protein was found to have homology to the proteins shown in the BLASTP data in Table 9E.  
               TABLE 9E                          Public BLASTP Results for NOV9a                                         NOV9a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q9NRY3   CD44-like precursor FELL -  Homo     1 . . . 897    897/897 (100%)   0.0             sapiens  (Human), 897 aa.   1 . . . 897    897/897 (100%)       AAO39681   Hyaluronan receptor for   1 . . . 897   896/897 (99%)   0.0           endocytosis -  Homo sapiens     520 . . . 1416    897/897 (99%)           (Human), 1416 aa (fragment).       Q8IUG9   FELE-2 -  Homo sapiens  (Human),   1 . . . 897   896/897 (99%)   0.0           2551 aa.   1655 . . . 2551    897/897 (99%)       Q8WWQ8   Stabilin-2 -  Homo sapiens  (Human),   1 . . . 897   896/897 (99%)   0.0           2551 aa.   1655 . . . 2551    897/897 (99%)       Q9H7H7   FLJ00112 protein -  Homo sapiens     1 . . . 897   896/897 (99%)   0.0           (Human), 1192 aa (fragment).   296 . . . 1192    897/897 (99%)                  
 
      PFam analysis predicts that the NOV9a protein contains the domains shown in the Table 9F.  
               TABLE 9F                          Domain Analysis of NOV9a                                             Identities/               Pfam   NOV9a   Similaritiesfor   Expect           0 Domain   Match Region   the Matched Region   Value                       Fasciclin    86 . . . 229   38/152 (25%)    1.5e−08                   100/152 (66%)            EGF   355 . . . 387   13/47 (28%)   0.24                   22/47 (47%)           EGF   397 . . . 426   13/47 (28%)   0.054                   23/47 (49%)           EGF   432 . . . 467   10/47 (21%)   0.066                   23/47 (49%)           EGF   473 . . . 510   13/47 (28%)   0.036                   31/47 (66%)           Xlink   543 . . . 636   40/104 (38%)    1.1e−26                   69/104 (66%)                       
 
     Example 10  
      The NOV10 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 10A.  
               TABLE 10A                       NOV10 Sequence Analysis                                                NOV10a, CG50925-01   SEQ ID NO: 257   7892 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAA at 4627                       ATG CGGGGGGCGCCCGCGCGCCTGCTGCTGCCGCTGCTGCCGTGGCTCCTGCTGCTCCTGGCGCCCGA           GGCTCGGGGCGCGCCCGGCTGCCCGCTATCCATCCGCAGCTGCAAGTGCTCGGGGGAGCGGCCCAAGG       GGCTGAGCGGCGGCGTCCCTGGCCCGGCTCGGCGGAGGGTGGTGTGCAGCGGCGGGGACCTCCCGGAG       CCTCCCGAGCCCGGCCTTCTGCCTAACGGCACCGTTACCCTTGGCAACCGTTTCTCCACTGCCCCTTG       CCCGCAGTCGGGGCTGGCCCAGTCTTTTCGATTGTGTCCAGAACAATACAGTAACGCCTCTGGTTGGG       TGAGTTCAGAGGCTGCCCGCTTCCTGACAGGACACAACTGGTCAGCCTCTGACGCTGGCCGCCCGGCC       TGCATTTTCCCCGGCCCGGTCTCCTGGAGACAGGTACCAGCTTACAACGCCGGACAGGATCAGGGTAG       CAAATATAGCTTCTATGGAGGAAAGGTCAAAGATGAGTATCTGCGTAGGTCCCCGATCTGTCGCTCTG       CTGCCGCCCTGCACACTGACACCAGTGCCCGCAGCTGGTCTGAATTTAGGCTCTTGAGCAATAACAAG       ATCACGGGGCTCCGCAATGGCTCCTTCCTGGGACTGTCACTGCTGGAGAAGCTTCTCATGAGAGCACA       TTTTTCTGATGAAGATGAAAAGACGGCCTGTCCTTCTCCAGCACCAAGGCTCTGGAGGCTGCATAGCA       AGTGCACCCTGAGCATGGCAGGCAATCAGAAGAACCAGGGCGGCAGCAGCTCACAAGAGGCAGCATCT       GGCTTGATGCCGAGTCGGCGGCTCCAGCGGGGAGAGGTTGAGGGCCTCTGCACTTGCCTCTGCACGGA       CCTGAGGAACAACATCATCAGCACAGTGCAGCCGGGCGCCTTCCTGGGCCTGGGGGAGCTGAAGCGTT       TAGATCTCTCCAACAACCGGATTGGCTGTCTCACCTCCGAGACCTTCCAGGGCCTCCCCAGGCTTCTC       CGACTAAACATATCTGGAAACATCTTCTCCAGTCTGCAACCTGGGGTCTTTGATGAGCTGCCAGCCCT       TAAGGTTGTGGACTTGGGCACCGAGTTCCTGACCTGTGACTGCCACCTGCGCTGGCTGCTGCCCTGGG       CCCAGAATCGCTCCCTGCAGCTGTCGGAACACACGCTCTGTGCTTACCCCAGTGCCCTGCATGCTCAT       GCCCTGGGCAGCCTCCAGGAGGCCCAGCTCTGCTGCGAGGGGGCCCTGGAGCTGCACACACACCACCT       CATCCCGTCCCTACGCCAAGTGGTGTTCCAGGGGGATCGGCTGCCCTTCCAGTGCTCTGCCAGCTACC       TGGGCAACGACACCCGCATCCGCTGGTACCACAACCGAGCCCCTGTGGAGGGTGATGAGCAGGCGGGC       ATCCTCCTGGCCGAGAGCCTCATCCACGACTGCACCTTCATCACCAGTGAGCTGACGCTGTCTCACAT       CGGCGTGTGGGCCTCAGGCGAGTGGGAGTGCACCGTGTCCATGGCCCAAGGCAACGCCAGCAAGAAGG       TGGAGATCGTGGTGCTGGAGACCTCTGCCTCCTACTGCCCCGCCGAGCGTGTTGCCAACAACCGCGGG       GACTTCAGGTGGCCCCGAACTCTGGCTGGCATCACAGCCTACCAGTCCTGCCTGCAGTATCCCTTCAC       CTCAGTGCCCCTGGGCGGGGGTGCCCCGGGCACCCGAGCCTCCCGCCGGTGTGACCGTGCCGGCCGCT       GGGAGCCAGGGGACTACTCCCACTGTCTCTACACCAACGACATCACCAGGGTGCTGTACACCTTCGTG       CTGATGCCCATCAATGCCTCCAATGCGCTGACCCTGGCTCACCAGCTGCGCGTGTACACAGCCGAGGC       CGCTAGCTTTTCAGACATGATGGATGTAGTCTATGTGGCTCAGATGATCCAGAAATTTTTGGGTTATG       TCGACCAGATCAAAGAGCTGGTAGAGGTGATGGTGGACATGCCCAGCAACTTGATGCTGGTGGACGAG       CACCTGCTGTGGCTGGCCCAGCGCGAGGACAAGGCCTGCAGCCGCATCGTGGGTGCCATAGAGCGCAT       TGGGGGGGCCGCCCTCAGCCCCCATGCCCAGCACATCTCAGTGAATGCGAGGAACGTGGCATTGGAGG       CCTACCTCATCAAGCCGCACAGCTACGTGGGCCTGACCTGCACAGCCTTCCAGAGGAGGGAGGGAGGG       GTGCCGGGCACACGGCCAGGAAGCCCTGGCCAGAACCCCCCACCTGAGCCCGAGCCCCCAGCTGACCA       GCAGCTCCGCTTCCGCTGCACCACCGGGAGGCCCAATGTTTCTCTGTCGTCCTTCCACATCAAGAACA       GCGTGGCCCTGGCCTCCATCCAGCTGCCCCCGAGTCTATTCTCATCCCTTCCGGCTGCCCTGGCTCCC       CCGGTGCCCCCAGACTGCACCCTGCAACTGCTCGTCTTCCGAAATGGCCGCCTCTTCCACAGCCACAG       CAACACCTCCCGCCCTGGAGCTGCTGGGCCTGGCAAGAGGCGTGGCGTGGCCACCCCCGTCATCTTCG       CAGGAACCAGTGGCTGTGGCGTGGGAAACCTGACAGAGCCAGTGGCCGTTTCGCTGCGGCACTGGGCT       GAGGGAGCCGAACCTGTGGCCGCTTGGTGGAGCCAGGAGGGGCCCGGGGAGGCTGGGGGCTGGACCTC       GGAGGGCTGCCAGCTCCGCTCCAGCCAGCCCAATGTCAGCGCCCTGCACTGCCAGCACTTGGGCAATG       TGGCCGTGCTCATGGAGCTGAGCGCCTTTCCCAGGGAGGTGGGGGGCGCCGGGGCAGGGCTGCACCCC       GTGGTATACCCCTGCACGGCCTTGCTGCTGCTCTGCCTCTTCGCCACCATCATCACCTACATCCTCAA       CCACAGCTCCATCCGTGTGTCCCGGAAAGGCTGGCACATGCTGCTGAACTTGTGCTTCCACATAGCCA       TGACCTCTGCTGTCTTTGCGGGGGGCATCACACTCACCAACTACCAGATGGTCTGCCAGGCGGTGGGC       ATCACCCTGCACTACTCCTCCCTATCCACGCTGCTCTGGATGGGCGTGAAGGCGCGAGTGCTCCATAA       GGAGCTCACCTGGAGGGCACCCCCTCCGCAAGAAGGGGACCCCGCTCTGCCTACTCCCAGTCCTATGC       TCCGGTACATACTTTCAATTCCAGCTTTGCAATTGGGGAGGGACTCCAACGCAGGCGTAGGAAACCTC       CCAAGGTTCTATTTGATCGCTGGAGGGATTCCACTCATTATCTGTGGCATCACAGCTGCAGTCAACAT               CCACAACTACCGGGACCACAGCCCCTACTGCTGGCTGGTGTGGCGTCCAAGCCTTGGCGCCTTCTACA       TCCCTGTGGCTTTGATTCTGCTCATCACCTGGATCTATTTCCTGTGCGCCGGGCTACGCTTACGGGGT       CCTCTGGCACAGAACCCCAAGGCGGGCAACAGCAGGGCCTCCCTGGAGGCAGGGGAGGAGCTGAGGGG       TTCCACCAGGCTCAGGGGCAGCGGCCCCCTCCTGAGTGACTCAGGTTCCCTTCTTGCTACTGGGAGCG       CGCGAGTGGGGACGCCCGGGCCCCCGGAGGATGGTGACAGCCTCTATTCTCCGGGAGTCCAGCTAGGG       GCGCTGGTGACCACGCACTTCCTGTACTTGGCCATGTGGGCCTGCGGGGCTCTGGCAGTGTCCCAGCG       CTGGCTGCCCCGGGTGGTGTGCAGCTGCTTGTACGGGGTGGCAGCCTCCGCCCTGGGCCTCTTCGTCT       TCACTCACCACTGTGCCAGGCGGAGGGACGTGAGAGCCTCGTGGCGCGCCTGCTGCCCCCCTGCCTCT       CCCGCGGCCCCCCATGCCCCGCCCCGGGCCCTGCCCGCCGCCGCAGAGGACGGTTCCCCGGTGTTCGG       GGAGGGGCCCCCCTCCCTCAAGTCCTCCCCAAGCGGCAGCAGCGGCCATCCGCTGGCTCTGGGCCCCT       GCAAGCTCACCAACCTGCAGCTGGCCCAGAGTCAGGTGTGCGAGGCGGGGGCGGCGGCCGGCGGGGAA       GGAGAGCCGGAGCCGGCGGGCACCCGGGGAAACCTCGCCCACCGCCACCCCAACAACGTGCACCACGG       GCGTCGGGCGCACAAGAGCCGGGCCAAGGGACACCGCGCGGGGGAGGCCTGCGGCAAGAACCGGCTCA       AGGCCCTGCGCGGGGGCGCGGCGGGGGCGCTGGAACTGCTGTCCAGCGAGAGCGGTAGTCTGCACAAC       AGCCCCACCGACAGCTACCTGGGCAGCAGCCGCAACAGCCCGGGCGCCGGCCTGCAGCTGGAAGGCGA       GCCCATGCTCACGCCGTCCGAGGGCAGCGACACCAGCGCCGCGCCGCTTTCTGAGGCGGGCCGGGCAG       GCCAGCGCCGCAGCGCCAGCCGCGACAGTCTCAAGGGCGGCGGCGCGCTGGAGAAGGAGAGCCATCGC       CGCTCGTACCCGCTCAACGCCGCCAGCCTAAACGGCGCCCCCAAGGGGGGCAAGTACGACGACGTCAC       CCTGATGGGCGCGGAGGTAGCCAGCGGCGGCTGCATGAAGACCGGACTCTGGAAGAGCGAAACTACCG       TC TAA   GGTGGGGCGGGCGACGCGGTAGACGGGTTGGCCACGCGGCTCGTTCCCCCGCTCCTCGGGGCC           CTCCAAGGTGTCTCCGTAGTCAGCAGGTTGGAGGCAGAGGAGCCGATGGCTGGAGGAAGCCCACAGGC           GGATGTTCCCCACTTGCCTAGAGGGCATCCCTCTGGGGTAGCGACAGACAATCCCAGAAACACGCATA           ATACATTTCCGTCCAGCCCGGGGCAGTCTGACTGTCGGTGCCCTCCCAGGAACGGGGAAGGCCTCCGT           CTGTGTGAAAGGGCACAGCACATCCCAGGTGCACCCTCCCCAAGTACTCCCACCCCGCCTACTGTCCA           TGCGGCCTCACTGGGGGCCATCAGCCTCACCAGCAAAGCAGAGATGAGAGCGTGGGAACTGTGTTCTT           TCCTCCCTGCCCTCTACTGATTTCAGCCCAGCCCCTGCCTAGATCCTAGGTCCCTTTTCCTCCCGAGT           TTGGCTGGCACGAGAGCTAGCCCAGCACATGAAGCAGGTGATGTTAAGTCACAAGGTGCTGCTTTTCA           GATCCACTATGCAAGAGGGGAGGGTGGGGCCACGTGAAAGGCAGCTCTAGACATCAACCAGTCCTGGG           GGAGGGGAGTGGGAACCGGGCACAACTAGGAACAATGCCACCATTCCCACAGGAGTGGTACTTAAACC           AGACAGCAGGGTTCAGAGGTGGCACACCGGGACAAAGCTGAGGCCCTGCACCTCAACAGCTGACTGCC           AGGTGCCTGTGGGTGAACTGAGGGGAGTAGAGGGAGAGGGCAGGTGGAACTGGGGCAGAATCTAGTCA           TGCCCTAAAGCTAGTCCTGTAAACAATGGTGCCCCAGAAAGCTGCAGGTGGTGTTTGGAGAAGCAGTT           ACTTTTCAGTTACAAGACCCATCTCCCTAGTCTCAGCCTTACAACACCACGGGACTAAGGAAGAGCAC           TTCCTTGCCTCCGTAAGGCCAGAGGAAGAACCATCCCAATCATTTGATCTCCAGCTCCACAGTAGAGA           GAAACCTACAAAATGTCAAACCAGCTTCCCGACTCCCAGGAGCTCAAGCCAAGCCCAGAGGCAGTGGC           TGGGGTCCCTGCAGGTCATGAGGGGCCTATGCCTTTACTCCTTTTAAACACCAGCACCCGTCTTTTCC           CCAACCTAAAACCAACCACCAGCATTTCACTACAGGACCAAATGGAAACCGAGGGAACCCTGGGTCTT           GGGAAGAACAACAGGAAACCAAGGTCTGACCTAGGGTTCCCTCCCAGTCTTCACATCACTCTGGCCTC           ATCACCAAGGTGACAGAGGACACAGGGGAGGGGGAAAACCCACACACACTCCTTGGAATGGGTCCTGT           TATTTATGCTTGCTGCACAGACATATTAGAAGAAAAAAAAAAAGCTTTGTATTATTCTTCCACATATG           CTGGCTGCTGTTTACACACCCTGCCAATGCCTTAGCACTGGAGAGCTTTTTGCAATATGCTGGGGAAA           GGGGAGGGAGGGAATGAAAGTGCCAAAGAAAACATGTTTTTAAGAACTCGGGTTTTATACAATAGAAT           GTTTTCTAGCAGATGCCTCTTGTTTTAATATATTAAAATTTTGCAAAGCCCTTTGAGCTACTGCCTTA           GTCTACCCACTGTCCTTTTGTTATGAGGTAGAGGATCTCATGACACCATACACACAAACCCATCATTG           CCTGTGAATGCACGTAGGGCCAGAATTCCCCAGTTCCCGCTCCTCTGAGGGTTGATACTGCTGGGAAT           GCCAACCACTCCACAAGCAGAGGGAAGCCCCCTCAGGCCTGCAGGAGGAGCCGCAGCAGTGTGTCCAA           TTCAAACCAGCAGCAAAGAGCCTGACATTTTCCCATCCATCTATGAGGAAAGCCATCTCACAGAACAT           GGACATAGGCAACTTGCTCTCCCACACCAAGGGATGGGAATCTCTCCTACCTATAGTCATCCCTGCAC           TCCTGACTTTACTCCAGGACCCAGGGTCCAACTAATGGCAGAGCCCCTCTTGGTTCCTTCAAACAAGA                   AAAGCAATACCTACGGACTGGTGTACACTTCCATCCTTGGTTATAACAGGAATGTTATCAAGCTGTCA           GAACAGGATGAAGTGCTCCCAGTGGATATCCATCAGGGAGGGTTAGGGACACTCGTGGCAGCCTGTCT           AGCAGCCTGGGCTCTCTGAAAGTCCCTAACTTCCTGAGGGGTACGCAAATACTGTTCTATTTCACTAT           CAGAAATGTTCTCATCTCCAGTGACAGTGGAGACAGGGGGTACAGGGCAGATCCGCTTCGGGGACTTC           AACATGCAGGGTGGCAAGAGAAGGGCAGGACTGGCCGGCCGCTTCCCCTGGGGTAAACCTAAGGAATT           ATTTCCCACCTCCCCTTCTCCTTGCCCCTGTCCCCACCCCGGTGGCTCCTTCTCTCGGGTCTCCACTT           CTGCTGTCCCATCCCGAAAGGCAGAGCGGACCAGTGACTGGCGGTGCTGGAGAAGGTCACCGATGTGC           TTCACCACAGACCGTTTGTCAAGTCTCAGAACTCGTAACCAGGCCAGCTGCTCAGCCATCCGCAGCAG           CACAGCCAGCAGCTCCTGCAGGCGGGAGGACGCCGGGTAGGGCAGGTCCACATTTGCCAATTTACAAA           ATCGGGCAAGGGAACATGAAAGCCGATCTGCAGGCTGCAGCGACTGCCAAGCCAGGAAAGTCGCAGCA           GTGATGACGGGCAAGGGATGCCTCCCGGTCACCAGCCACGTCTCATTTGCCAGCTCCACCAACTGCAT           TGTTCGAGACAGCATCTTCTCTTTGTCTTCCACGTATTTGGCTGGCACAGAAGGTGAAGCTTGGAACA           GTTTGAAGCTGAAATAACCAAAATGAGGGTTGGATCTTAATGATATAGGGGCTGCTCTCCCACAGTGA           GGAAAGACAGCCCACTCAAGATGGGGAAGCTATTCTGCCCTCAGGAATACTCAAGCTCACTGGGCAGC           AAGTTAATAAAGGTAGTGAGAGAAAACAGGGCGTCTTCCGCTTGTTAGGGGAAGGTGGAGGGATGGAG           GAGAGCACGAACATTTATTGGGCGCCTCCCAATCACCATTATTCTGAGTGCTTTACAACGTTCTCATT           TAATCTACGTGCACGTGCACCATCTTATGTGCATGTATAGTTAAAAAACTTTCCCATAGTCATCCAGC           CAGGCAGTAACCAAGCTTCAAATACAAGGCTATTTGACACCAACAGCCTCTACTTTCAACGTTATTTA           TCAG                                           NOV10a, CG50925-01   SEQ ID NO: 258   1542 aa   MW at 164901.2kD           Protein Sequence                     MRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPE           PPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA       CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNK       ITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAAS       GLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLL       RLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAH       ALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAG       ILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRG       DFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFV       LMPINASNALTLAHQLRVYTAEAASFSDNMDVVYVAQMIQKFLGYVDQIKELVEVMVDMPSNLMLVDE       HLLWLAQREDKACSRIVGAIERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGG       VPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAP       PVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWA       EGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHP       VVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVG       ITLHYSSLSTLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRYILSIPALQLGRDSNAGVGNL       PRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRG       PLAQNPKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLG       ALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPAS       PAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGE       GEPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGGAAGALELLSSESGSLHN       SPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHR       RSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCMKTGLWKSETTV                                     NOV10b, CG50925-08   SEQ ID NO: 259   4103 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAA at 3991                       ATG CGGGGGGCGCCCGCGCGCCTGCTGCTGCCGCTGCTGCCGTGGCTCCTGCTGCTCCTGGCGCCCGA           GGCTCGGGGCGCGCCCGGCTGCCCGCTATCCATCCGCAGCTGCAAGTGCTCGGGGGAGCGGCCCAAGG       GGCTGAGCGGCGGCGTCCCTGGCCCGGCTCGGCGGAGGGTGGTGTGCAGCGGCGGGGACCTCCCGGAG       CCTCCCGAGCCCGGCCTTCTGCCTAACGGCACCGTTACCCTTGACCTGAGGAACAACATCATCAGCAC       AGTGCAGCCGGGCGCCTTCCTGGGCCTGGGGGAGCTGAAGCGTTTAGATCTCTCCAACAACCGGATTG       GCTGTCTCACCTCCGAGACCTTCCAGGGCCTCCCCAGGCTTCTCCGACTAAACATATCTGGAAACATC       TTCTCCAGTCTGCAACCTGGGGTCTTTGATGAGCTGCCAGCCCTTAAGGTTGTGGACTTGGGCACCGA       GTTCCTGACCTGTGACTGCCACCTGCGCTGGCTGCTGCCCTGGGCCCAGAATCGCTCCCTGCAGCTGT       CGGAACACACGCTCTGTGCTTACCCCAGTGCCCTGCATGCTCATGCCCTGGGCAGCCTCCAGGAGGCC       CAGCTCTGCTGCGAGGGGGCCCTGGAGCTGCACACACACCACCTCATCCCGTCCCTACGCCAAGTGGT       GTTCCAGGGGGATCGGCTGCCCTTCCAGTGCTCTGCCAGCTACCTGGGCAACGACACCCGCATCCGCT       GGTACCACAACCGAGCCCCTGTGGAGGGTGATGAGCAGGCGGGCATCCTCCTGGCCGAGAGCCTCATC       CACGACTGCACCTTCATCACCAGTGAGCTGACGCTGTCTCACATCGGCGTGTGGGCCTCAGGCGAGTG       GGAGTGCACCGTGTCCATGGCCCAAGGCAACGCCAGCAAGAAGGTGGAGATCGTGGTGCTGGAGACCT       CTGCCTCCTACTGCCCCGCCGAGCGTGTTGCCAACAACCGCGGGGACTTCAGGTGGCCCCGAACTCTG       GCTGGCATCACAGCCTACCAGTCCTGCCTGCAGTATCCCTTCACCTCAGTGCCCCTGGGCGGGGGTGC       CCCGGGCACCCGAGCCTCCCGCCGGTGTGACCGTGCCGGCCGCTGGGAGTCAGGGGACTACTCCCACT       GTCTCTACACCAACGACATCACCAGGGTGCTGTACACCTTCGTGCTGATGCCCATCAATGCCTCCAAT       GCGCTGACCCTGGCTCACCAGCTGCGCGTGTACACAGCCGAGGCCGCTAGCTTTTCAGACATGATGGA       TGTAGTCTATGTGGCTCAGATGATCCAGAAATTTTTGGGTTATGTCGACCAGATCAAAGAGCTGGTAG       AGGTGATGGTGGACATGGCCAGCAACTTGATGCTGGTGGACGAGCACCTGCTGTGGCTGGCCCAGCGC       GAGGACAAGGCCTGCAGCCGCATCGTGGGTGCCCTGGAGCGCATTGGGGGGGCCGCCCTCAGCCCCCA       TGCCCAGCACATCTCAGTGAATGCGAGGAACGTGGCATTGGAGGCCTACCTCATCAAGCCGCACAGCT       ACGTGGGCCTGACCTGCACAGCCTTCCAGAGGAGGGAGGGAGGGGTGCCGGGCACACGGCCAGGAAGC       CCTGGCCAGAACCCCCCACCTGAGCCCGAGCCCCCAGCTGACCAGCAGCTCCGCTTCCGCTGCACCAC       CGGGAGGCCCAATGTTTCTCTGTCGTCCTTCCACATCAAGAACAGCGTGGCCCTGGCCTCCATCCAGC       TGCCCCCGAGTCTATTCTCATCCCTTCCGGCTGCCCTGGCTCCCCCGGTGCCCCCAGACTGCACCCTG       CAACTGCTCGTCTTCCGAAATGGCCGCCTCTTCCACAGCCACAGCAACACCTCCCGCCCTGGAGCTGC       TGGGCCTGGCAAGAGGCGTGGCGTGGCCACCCCCGTCATCTTCGCAGGAACCAGTGGCTGTGGCGTGG       GAAACCTGACAGAGCCAGTGGCCGTTTCGCTGCGGCACTGGGCTGAGGGAGCCGAACCTGTGGCCGCT       TGTTGGAGCCAGGAGGGGCCCGGGGAGGCTGGGGGCTGGACCTCGGAGGGCTGCCAGCTCCGCTCCAG       CCAGCCCAATGTCAGCGCCCTGCACTGCCAGCACTTGGGCAATGTGGCCGTGCTCATGGAGCTGAGCG       CCTTTCCCAGGGAGGTGGGGGGCGCCGGGGCAGGGCTGCACCCCGTGGTATACCCCTGCACGGCCTTG       CTGCTGCTCTGCCTCTTCGCCACCATCATCACCTACATCCTCAACCACAGCTCCATCCGTGTGTCCCG       GAAAGGCTGGCACATGCTGCTGAACTTGTGCTTCCACATAGCCATGACCTCTGCTGTCTTTGCGGGGG       GCATCACACTCACCAACTACCAGATGGTCTGCCAGGCGGTGGGCATCACCCTGCACTACTCCTCCCTA       TCCACGCTGCTCTGGATGGGCGTGAAGGCGCGAGTGCTCCATAAGGAGCTCACCTGGAGGGCACCCCC       TCCGCAAGAAGGGGACCCCGCTCTGCCTACTCCCAGTCCTATGCTCCGGTACATACTTTCAATTCCAG       CTTTGCAATTGGGGAGGGACTCCAACGCAGGCGTAGGAAACCTCCCAAGGTTCTATTTGATCGCTGGA       GGGATTCCACTCATTATCTGTGGCATCACAGCTGCAGTCAACATTCACAACTACCGGGACCACAGCCC       CTACTGCTGGCTGGTGTGGCGTCCAAGCCTTGGCGCCTTCTACATCCCTGTGGCTTTGATTCTGCTCA       TCACCTGGATCTATTTCCTGTGCGCCGGGCTACGCTTACGGGGTCCTCTGGCACAGAACCCCAAGGCG       GGCAACAGCAGGGCCTCCCTGGAGGCAGGGGAGGAGCTGAGGGGTTCCACCAGGCTCAGGGGCAGCGG       CCCCCTCCTGAGTGACTCAGGTTCCCTTCTTGCTACTGGGAGCGCGCGAGTGGGGACGCCCGGGCCCC       CGGAGGATGGTGACAGCCTCTATTCTCCGGGAGTCCAGCTAGGGGCGCTGGTGACCACGCACTTCCTG       TACTTGGCCATGTGGGCCTGCGGGGCTCTGGCAGTGTCCCAGCGCTGGCTGCCCCGGGTGGTGTGCAG       CTGCTTGTACGGGGTGGCAGCCTCCGCCCTGGGCCTCTTCGTCTTCACTCACCACTGTGCCAGGCGGA       GGGACGTGAGAGCCTCGTGGCGCGCCTGCTGCCCCCCTGCCTCTCCCGCGGCCCCCCATGCCCCGCCC       CGGGCCCTGCCCGCCGCCGCAGAGGACGGTTCCCCGGTGTTCGGGGAGGGGCCCCCCTCCCTCAAGTC               CTCCCCAAGCGGCAGCAGCGGCCATCCGCTGGCTCTGGGCCCCTGCAAGCTCACCAACCTGCAGCTGG       CCCAGAGTCAGGTGTGCGAGGCGGGGGCGGCGGCCGGCGGGGAAGGAGAGCCGGAGCCGGCGGGCACC       CGGGGAAACCTCGCCCACCGCCACCCCAACAACGTGCACCACGGGCGTCGGGCGCACAAGAGCCGGGC       CAAGGGACACCGCGCGGGGGAGGCCTGCGGCAAGAACCGGCTCAAGGCCCTGCGCGGGGGCGCGGCGG       GGGCGCTGGAACTGCTGTCCAGCGAGAGCGGTAGTCTGCACAACAGCCCCACCGACAGCTACCTGGGC       AGCAGCCGCAACAGCCCGGGCGCCGGCCTGCAGCTGGAAGGCGAGCCCATGCTCACGCCGTCCGAGGG       CAGCGACACCAGCGCCGCGCCGCTTTCTGAGGCGGGCCGGGCAGGCCAGCGCCGCAGCGCCAGCCGCG       ACAGTCTCAAGGGCGGCGGCGCGCTGGAGAAGGAGAGCCATCGCCGCTCGTACCCGCTCAACGCCGCC       AGCCTAAACGGCGCCCCCAAGGGGGGCAAGTACGACGACGTCACCCTGATGGGCGCGGAGGTAGCCAG       CGGCGGCTGCATGAAGACCGGACTCTGGAAGAGCGAAACTACCGTC TAA   GGTGGGGCGGGCGACGCGG           TAGACGGGTTGGCCACGCGGCTCGTTCCCCCGCTCCTCGGGGCCCTCCAAGGTGTCTCCGTAGTCAGC           AGGTTGGAGGCAGAGGAGCCGAT                                           NOV10b, CG50925-08   SEQ ID NO: 260   1330 aa   MW at 141782.5kD           Protein Sequence                     MRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPE           PPEPGLLPNGTVTLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNI       FSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEA       QLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLI       HDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTL       AGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWESGDYSHCLYTNDITRVLYTFVLMPINASN       ALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQR       EDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGS       PGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTL       QLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAA       WWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTAL       LLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSL       STLLWMGVKARVLHKELTWEAPPPQEGDPALPTPSPMLRYILSIPALQLGRDSNAGVGNLPRFYLIAG       GIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKA       GNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHFL       YLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPAAPHAPP       RALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQIAQSQVCEAGAAAGGEGEPEPAGT       RGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGGAAGALELLSSESGSLHNSPTDSYLG       SSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHPRSYPLNAA       SLNGAPKGGKYDDVTLMGAEVASGGCMKTGLWKSETTV                                     NOV10c, 226990087   SEQ ID NO: 261   341 bp           DNA Sequence   ORF Start: at 3   ORF Stop: end of sequence                       CA ACCGGATCCGAGCTGAAGCGTTTAGATCTCTCCAACAACCGGATTGGCTGTCTCACCTCCGAGACC           TTCCAGGGCCTCCCCAGGCTTCTCCGACTAAACATATCTGGAAACATCTTCTCCAGTCTGCAACCTGG       GGTCTTTGATGAGCTGCCAGCCCTTAAGGTTGTGGACTTGGGCACCGAGTTCCTGACCTGTGACTGCC       ACCTGCGCTGGCTGCTGCCCTGGGCCCAGAATCGCTCCCTGCAGCTGTCGGAACACACGCTCTGTGCT       TACCCCAGTGCCCTGCATGCTCAGGCCCTGGGCAGCCTCCAGGAGGCCCAGCTCTGCTGCGAGCTCGA       G                                         NOV10c, 226990087   SEQ ID NO: 262   113 aa   MW at 12539.2kD           Protein Sequence                     TGSELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCH           LRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCELE                                     NOV10d, 320054488   SEQ ID NO: 263   2227 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCGCGCCCGGCTGCCCGCTATCCATCCGCAGCTGCAAGTGCTCGGGGGAGCGGGCCAAGG           GGCTGAGCGGCGGCGTCCCTGGCCCGGCTCGGCGGAGGGTGGTGTGCAGCGGCGGGGACCTCCCGGAG       CCTCCCGAGCCCGGCCTTCTGCCTAACGGCACCGTTACCCTGCTCTTGAGCAATAACAAGATCACGGG       GCTCCGCAATGGCTCCTTCCTGGGACTGTCACTGCTGGAGAAGCTGGACCTGAGGAACAACATCATCA       GCACAGTGCAGCCGGGCGCCTTCCTGGGCCTGGGGGAGCTGAAGCGTTTAGATCTCTCCAACAACCGG       ATTGGCTGTCTCACCTCCGAGACCTTCCAGGGCCTCCCCAGGCTTCTCCGACTAAACATATCTGGAAA       CATCTTCTCCAGTCTGCAACCTGGGGTCTTTGATGAGCTGCCAGCCCTTAAGGTTGTGGACTTGGGCA       CCGAGTTCCTGACCTGTGACTGCCACCTGCGCTGGCTGCTGCCCTGGGCCCAGAATCGCTCCCTGCAG       CTGTCGGAACACACGCTCTGTGCTTACCCCAGTGCCCTGCATGCTCAGGCCCTGGGCAGCCTCCAGGA       GGCCCAGCTCTGCTGCGAGGGGGCCCTGGAGCTGCACACACACCACCTCATCCCGTCCCTACGCCAAG       TGGTGTTCCAGGGGGATCGGCTGCCCTTCCAGTGCTCTGCCAGCTACCTGGGCAACGACACCCGCATC       CGCTGGTACCACGACCGAGCCCCTGTGGAGGGTGATGAGCAGGCGGGCATCCTCCTGGCCGAGAGCCT       CATCCACGACTGCACCTTCATCACCAGTGAGCTGACGCTGTCTCACATCGGCGTGTGGGCCTCAGGCG       AGTGGGAGTGCACCGTGTCCATGGCCCAAGGCAACGCCAGCAAGAAGGTGGAGATCGTGGTGCTGGAG       ACCTCTGCCTCCTACTGCCCCGCCGAGCGTGTTGCCAACAACCGCGGGGACTTCAGGTGGCCCCGAAC       TCTGGCTGGCATCACAGCCTACCAGTCCTGCCTGCAGTATCCCTTCACCTCAGTGCCCCTGGGCGGGG       GTGCCCCGGGCACCCGAGCCTCCCGCCGGTGTGACCGTGCCGGCCGCTGGGAGCCAGGGGACTACTCC       CACTGTCTCTACACCAACGACATCACCAGGGTGCTGTACACCTTCGTGCTGATGCCCATCAATGCCTC       CAATGCGCTGACCCTGGCTCACCAGCTGCGCGTGTACACAGCCGAGGCCGCTAGCTTTTCAGACATGA       TGGATGTAGTCTATGTGGCTCAGATGATCCAGAAATTTTTGGGTTATGTCGACCAGATCAAAGAGCTG       GTAGAGGTGATGGTGGACATGGCCAGCAACCTGATGCTGGTGGACGAGCACCTGCTGTGGCTGGCCCA       GCGCGAGGACAAGGCCTGCAGCCGCATCGTGGGTGCCCTGGAGCGCATTGGGGGGGCCGCCCTCAGCC       CCCATGCCCAGCACATCTCAGTGAATGCGAGGAACGTGGCATTGGAGGCCTACCTCATCAAGCCGCAC       AGCTACGTGGGCCTGACCTGCACAGCCTTCCAGAGGAGGGAGGGAGGGGTGCCGGGCACACGGCCAGG       AAGCCCTGGCCAGAACCCCCCACCTGAGCCCGAGCCCCCAGCTGACCAGCAGCTCCGCTTCCGCTGCA       CCACCGGGAGGCCCAATGTTTCTCTGTCGTCCTTCCACATCAAGAACAGCGTGGCCCTGGCCTCCATC       CAGCTGCCCCCGAGTCTATTCTCATCCCTTCCGGCTGCCCTGGCTCCCCCGGTGCCCCCAGACTGCAC       CCTGCAACTGCTCGTCTTCCGAAATGGCCGCCTCTTCCACAGCCACAGCAACACCTCCCGCCCTGGAG       CTGCTGGGCCTGGCAAGAGGCGTGGCGTGGCCACCCCCGTCATCTTCGCAGGAACCAGTGGCTGTGGC       GTGGGAAACCTGACAGAGCCAGTGGCCGTTTCGCTGCGGCACTGGGCTGAGGGAGCCGAACCTGTGGC       CGCTTGGTGGAGCCAGGAGGGGCCCGGGGAGGCTGGGGGCTGGACCTCGGAGGGCTGCCAGCTCCGCT       CCAGCCAGCCCAATGTCAGCGCCCTGCACTGCCAGCACTTGGGCAATGTGGCCGTGCTCATGGAGCTG       AGCGCCTTTCCCAGGGAGGTGGGGGGCGCCGGGGCAGGGCTGCTCGAGGGC                                         NOV10d, 320054488   SEQ ID NO: 264   742 aa   MW at 79823.1kD           Protein Sequence                     TGSAPGCPLSIRSCKCSGEPAKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITG           LRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGN       IFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQE       AQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHDRAPVEGDEQAGILLAESL       IHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRT       LAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDPAGRWEPGDYSHCLYTNDITRVLYTFVLMPINAS       NALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQ       REDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPG       SPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCT       LQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVA       AWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLLEG                                     NOV10e, CG50925-02   SEQ ID NO: 265   7860 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAA at 4627                       ATG CGGGGGGCGCCCGCGCGCCTGCTGCTGCCGCTGCTGCCGTGGCTCCTGCTGCTCCTGGCGCCCGA           GGCTCGGGGCGCGCCCGGCTGCCCGCTATCCATCCGCAGCTGCAAGTGCTCGGGGGAGCGGCCCAAGG       GGCTGAGCGGCGGCGTCCCTGGCCCGGCTCGGCGGAGGGTGGTGTGCAGCGGCGGGGACCTCCCGGAG       CCTCCCGAGCCCGGCCTTCTGCCTAACGGCACCGTTACCCTTGGCAACCGTTTCTCCACTGCCCCTTG       CCCGCAGTCGGGGCTGGCCCAGTCTTTTCGATTGTGTCCAGAACAATACAGTAACGCCTCTGGTTGGG       TGAGTTCAGAGGCTGCCCGCTTCCTGACAGGACACAACTGGTCAGCCTCTGACGCTGGCCGCCCGGCC       TGCATTTTCCCCGGCCCGGTCTCCTGGAGACAGGTACCAGCTTACAACGCCGGACAGGATCAGGGTAG       CAAATATAGCTTCTATGGAGGAAAGGTCAAAGATGAGTATCTGCGTAGGTCCCCGATCTGTCGCTCTG       CTGCCGCCCTGCACACTGACACCAGTGCCCGCAGCTGGTCTGAATTTAGGCTCTTGAGCAATAACAAG       ATCACGGGGCTCCGCAATGGCTCCTTCCTGGGACTGTCACTGCTGGAGAAGCTTCTCATGAGAGCACA       TTTTTCTGATGAAGATGAAAAGACGGCCTGTCCTTCTCCAGCACCAAGGCTCTGGAGGCTGCATAGCA       AGTGCACCCTGAGCATGGCAGGCAATCAGAAGAACCAGGGCGGCAGCAGCTCACAAGAGGCAGCATCT       GGCTTGATGCCGAGTCGGCGGCTCCAGCGGGGAGAGGTTGAGGGCCTCTGCACTTGCCTCTGCACGGA       CCTGAGGAACAACATCATCAGCACAGTGCAGCCGGGCGCCTTCCTGGGCCTGGGGGAGCTGAAGCGTT       TAGATCTCTCCAACAACCGGATTGGCTGTCTCACCTCCGAGACCTTCCAGGGCCTCCCCAGGCTTCTC       CGACTAAACATATCTGGAAACATCTTCTCCAGTCTGCAACCTGGGGTCTTTGATGAGCTGCCAGCCCT       TAAGGTTGTGGACTTGGGCACCGAGTTCCTGACCTGTGACTGCCACCTGCGCTGGCTGCTGCCCTGGG       CCCAGAATCGCTCCCTGCAGCTGTCGGAACACACGCTCTGTGCTTACCCCAGTGCCCTGCATGCTCAT       GCCCTGGGCAGCCTCCAGGAGGCCCAGCTCTGCTGCGAGGGGGCCCTGGAGCTGCACACACACCACCT       CATCCCGTCCCTACGCCAAGTGGTGTTCCAGGGGGATCGGCTGCCCTTCCAGTGCTCTGCCAGCTACC       TGGGCAACGACACCCGCATCCGCTGGTACCACAACCGAGCCCCTGTGGAGGGTGATGAGCAGGCGGGC       ATCCTCCTGGCCGAGAGCCTCATCCACGACTGCACCTTCATCACCAGTGAGCTGACGCTGTCTCACAT       CGGCGTGTGGGCCTCAGGCGAGTGGGAGTGCACCGTGTCCATGGCCCAAGGCAACGCCAGCAAGAAGG       TGGAGATCGTGGTGCTGGAGACCTCTGCCTCCTACTGCCCCGCCGAGCGTGTTGCCAACAACCGCGGG       GACTTCAGGTGGCCCCGAACTCTGGCTGGCATCACAGCCTACCAGTCCTGCCTGCAGTATCCCTTCAC       CTCAGTGCCCCTGGGCGGGGGTGCCCCGGGCACCCGAGCCTCCCGCCGGTGTGACCGTGCCGGCCGCT       GGGAGCCAGGGGACTACTCCCACTGTCTCTACACCAACGACATCACCAGGGTGCTGTACACCTTCGTG       CTGATGCCCATCAATGCCTCCAATGCGCTGACCCTGGCTCACCAGCTGCGCGTGTACACAGCCGAGGC       CGCTAGCTTTTCAGACATGATGGATGTAGTCTATGTGGCTCAGATGATCCAGAAATTTTTGGGTTATG       TCGACCAGATCAAAGAGCTGGTAGAGGTGATGGTGGACATGCCCAGCAACTTGATGCTGGTGGACGAG       CACCTGCTGTGGCTGGCCCAGCGCGAGGACAAGGCCTGCAGCCGCATCGTGGGTGCCATAGAGCGCAT       TGGGGGGGCCGCCCTCAGCCCCCATGCCCAGCACATCTCAGTGAATGCGAGGAACGTGGCATTGGAGG       CCTACCTCATCAAGCCGCACAGCTACGTGGGCCTGACCTGCACAGCCTTCCAGAGGAGGGAGGGAGGG       GTGCCGGGCACACGGCCAGGAAGCCCTGGCCAGAACCCCCCACCTGAGCCCGAGCCCCCAGCTGACCA       GCAGCTCCGCTTCCGCTGCACCACCGGGAGGCCCAATGTTTCTCTGTCGTCCTTCCACATCAAGAACA       GCGTGGCCCTGGCCTCCATCCAGCTGCCCCCGAGTCTATTCTCATCCCTTCCGGCTGCCCTGGCTCCC       CCGGTGCCCCCAGACTGCACCCTGCAACTGCTCGTCTTCCGAAATGGCCGCCTCTTCCACAGCCACAG       CAACACCTCCCGCCCTGGAGCTGCTGGGCCTGGCAAGAGGCGTGGCGTGGCCACCCCCGTCATCTTCG       CAGGAACCAGTGGCTGTGGCGTGGGAAACCTGACAGAGCCAGTGGCCGTTTCGCTGCGGCACTGGGCT       GAGGGAGCCGAACCTGTGGCCGCTTGGTGGAGCCAGGAGGGGCCCGGGGAGGCTGGGGGCTGGACCTC       GGAGGGCTGCCAGCTCCGCTCCAGCCAGCCCAATGTCAGCGCCCTGCACTGCCAGCACTTGGGCAATG       TGGCCGTGCTCATGGAGCTGAGCGCCTTTCCCAGGGAGGTGGGGGGCGCCGGGGCAGGGCTGCACCCC       GTGGTATACCCCTGCACGGCCTTGCTGCTGCTCTGCCTCTTCGCCACCATCATCACCTACATCCTCAA       CCACAGCTCCATCCGTGTGTCCCGGAAAGGCTGGCACATGCTGCTGAACTTGTGCTTCCACATAGCCA       TGACCTCTGCTGTCTTTGCGGGGGGCATCACACTCACCAACTACCAGATGGTCTGCCAGGCGGTGGGC       ATCACCCTGCACTACTCCTCCCTATCCACGCTGCTCTGGATGGGCGTGAAGGCGCGAGTGCTCCATAA       GGAGCTCACCTGGAGGGCACCCCCTCCGCAAGAAGGGGACCCCGCTCTGCCTACTCCCAGTCCTATGC       TCCGGTACATACTTTCAATTCCAGCTTTGCAATTGGGGAGGGACTCCAACGCAGGCGTAGGAAACCTC       CCAAGGTTCTATTTGATCGCTGGAGGGATTCCACTCATTATCTGTGGCATCACAGCTGCAGTCAACAT               CCACAACTACCGGGACCACAGCCCCTACTGCTGGCTGGTGTGGCGTCCAAGCCTTGGCGCCTTCTACA       TCCCTGTGGCTTTGATTCTGCTCATCACCTGGATCTATTTCCTGTGCGCCGGGCTACGCTTACGGGGT       CCTCTGGCACAGAACCCCAAGGCGGGCAACAGCAGGGCCTCCCTGGAGGCAGGGGAGGAGCTGAGGGG       TTCCACCAGGCTCAGGGGCAGCGGCCCCCTCCTGAGTGACTCAGGTTCCCTTCTTGCTACTGGGAGCG       CGCGAGTGGGGACGCCCGGGCCCCCGGAGGATGGTGACAGCCTCTATTCTCCGGGAGTCCAGCTAGGG       GCGCTGGTGACCACGCACTTCCTGTACTTGGCCATGTGGGCCTGCGGGGCTCTGGCAGTGTCCCAGCG       CTGGCTGCCCCGGGTGGTGTGCAGCTGCTTGTACGGGGTGGCAGCCTCCGCCCTGGGCCTCTTCGTCT       TCACTCACCACTGTGCCAGGCGGAGGGACGTGAGAGCCTCGTGGCGCGCCTGCTGCCCCCCTGCCTCT       CCCGCGGCCCCCCATGCCCCGCCCCGGGCCCTGCCCGCCGCCGCAGAGGACGGTTCCCCGGTGTTCGG       GGAGGGGCCCCCCTCCCTCAAGTCCTCCCCAAGCGGCAGCAGCGGCCATCCGCTGGCTCTGGGCCCCT       GCAAGCTCACCAACCTGCAGCTGGCCCAGAGTCAGGTGTGCGAGGCGGGGGCGGCGGCCGGCGGGGAA       GGAGAGCCGGAGCCGGCGGGCACCCGGGGAAACCTCGCCCACCGCCACCCCAACAACGTGCACCACGG       GCGTCGGGCGCACAAGAGCCGGGCCAAGGGACACCGCGCGGGGGAGGCCTGCGGCAAGAACCGGCTCA       AGGCCCTGCGCGGGGGCGCGGCGGGGGCGCTGGAACTGCTGTCCAGCGAGAGCGGTAGTCTGCACAAC       AGCCCCACCGACAGCTACCTGGGCAGCAGCCGCAACAGCCCGGGCGCCGGCCTGCAGCTGGAAGGCGA       GCCCATGCTCACGCCGTCCGAGGGCAGCGACACCAGCGCCGCGCCGCTTTCTGAGGCGGGCCGGGCAG       GCCAGCGCCGCAGCGCCAGCCGCGACAGTCTCAAGGGCGGCGGCGCGCTGGAGAAGGAGAGCCATCGC       CGCTCGTACCCGCTCAACGCCGCCAGCCTAAACGGCGCCCCCAAGGGGGGCAAGTACGACGACGTCAC       CCTGATGGGCGCGGAGGTAGCCAGCGGCGGCTGCATGAAGACCGGACTCTGGAAGAGCGAAACTACCG       TC TAA   GGTGGGGCGGGCGACGCGGTAGACGGGTTGGCCACGCGGCTCGTTCCCCCGCTCCTCGGGGCC           CTCCAAGGTGTCTCCGTAGTCAGCAGGTTGGAGGCAGAGGAGCCGATGGCTGGAGGAAGCCCACAGGC           GGATGTTCCCCACTTGCCTAGAGGGCATCCCTCTGGGGTAGCGACAGACAATCCCAGAAACACGCATA           ATACATTTCCGTCCAGCCCGGGGCAGTCTGACTGTCGGTGCCCTCCCAGGAACGGGGAAGGCCTCCGT           CTGTGTGAAAGGGCACAGCACATCCCAGGTGCACCCTCCCCAAGTACTCCCACCCCGCCTACTGTCCA           TGCGGCCTCACTGGGGGCCATCAGCCTCACCAGCAAAGCAGAGATGAGAGCGTGGGAACTGTGTTCTT           TCCTCCCTGCCCTCTACTGATTTCAGCCCAGCCCCTGCCTAGATCCTAGGTCCCTTTTCCTCCCGAGT           TTGGCTGGCACGAGAGCTAGCCCAGCACATGAAGCAGGTGATGTTAAGTCACAAGGTGCTGCTTTTCA           GATCCACTATGCAAGAGGGGAGGGTGGGGCCACGTGAAAGGCAGCTCTAGACATCAACCAGTCCTGGG           GGAGGGGAGTGGGAACCGGGCACAACTAGGAACAATGCCACCATTCCCACAGGAGTGGTACTTAAACC           AGACAGCAGGGTTCAGAGGTGGCACACCGGGACAAAGCTGAGGCCCTGCACCTCAACAGCTGACTGCC           AGGTGCCTGTGGGTGAACTGAGGGGAGTAGAGGGAGAGGGCAGGTGGAACTGGGGCAGAATCTAGTCA           TGCCCTAAAGCTAGTCCTGTAAACAATGGTGCCCCAGAAAGCTGCAGGTGGTGTTTGGAGAAGCAGTT           ACTTTTCAGTTACAAGACCCATCTCCCTAGTCTCAGCCTTACAACACCACGGGACTAAGGAAGAGCAC           TTCCTTGCCTCCGTAAGGCCAGAGGAAGAACCATCCCAATCATTTGATCTCCAGCTCCACAGTAGAGA           GAAACCTACAAAATGTCAAACCAGCTTCCCGACTCCCAGGAGCTCAAGCCAAGCCCAGAGGCAGTGGC           TGGGGTCCCTGCAGGTCATGAGGGGCCTATGCCTTTACTCCTTTTAAACACCAGCACCCGTCTTTTCC           CCAACCTAAAACCAACCACCAGCATTTCACTACAGGACCAAATGGAAACCGAGGGAACCCTGGGTCTT           GGGAAGAACAACAGGAAACCAAGGTCTGACCTAGGGTTCCCTCCCAGTCTTCACATCACTCTGGCCTC           ATCACCAAGGTGACAGAGGACACAGGGGAGGGGGAAAACCCACACACACTCCTTGGAATGGGTCCTGT           TATTTATGCTTGCTGCACAGACATATTAGAAGAAAAAAAAAAAGCTTTGTATTATTCTTCCACATATG           CTGGCTGCTGTTTACACACCCTGCCAATGCCTTAGCACTGGAGAGCTTTTTGCAATATGCTGGGGAAA           GGGGAGGGAGGGAATGAAAGTGCCAAAGAAAACATGTTTTTAAGAACTCGGGTTTTATACAATAGAAT           GTTTTCTAGCAGATGCCTCTTGTTTTAATATATTAAAATTTTGCAAAGCCCTTTGAGCTACTGCCTTA           GTCTACCCACTGTCCTTTTGTTATGAGGTAGAGGATCTCATGACACCATACACACAAACCCATCATTG           CCTGTGAATGCACGTAGGGCCAGAATTCCCCAGTTCCCGCTCCTCTGAGGGTTGATACTGCTGGGAAT           GCCAACCACTCCACAAGCAGAGGGAAGCCCCCTCAGGCCTGCAGGAGGAGCCGCAGCAGTGTGTCCAA           TTCAAACCAGCAGCAAAGAGCCTGACATTTTCCCATCCATCTATGAGGAAAGCCATCTCACAGAACAT           GGACATAGGCAACTTGCTCTCCCACACCAAGGGATGGGAATCTCTCCTACCTATAGTCATCCCTGCAC           TCCTGACTTTACTCCAGGACCCAGGGTCCAACTAATGGCAGAGCCCCTCTTGGTTCCTTCAAACAAGA                   AAAGCAATACCTACGGACTGGTGTACACTTCCATCCTTGGTTATAACAGGAATGTTATCAAGCTGTCA           GAACAGGATGAAGTGCTCCCAGTGGATATCCATCAGGGAGGGTTAGGGACACTCGTGGCAGCCTGTCT           AGCAGCCTGGGCTCTCTGAAAGTCCCTAACTTCCTGAGGGGTACGCAAATACTGTTCTATTTCACTAT           CAGAAATGTTCTCATCTCCAGTGACAGTGGAGACAGGGGGTACAGGGCAGATCCGCTTCGGGGACTTC           AACATGCAGGGTGGCAAGAGAAGGGCAGGACTGGCCGGCCGCTTCCCCTGGGGTAAACCTAAGGAATT           ATTTCCCACCTCCCCTTCTCCTTGCCCCTGTCCCCACCCCGGTGGCTCCTTCTCTCGGGTCTCCACTT           CTGCTGTCCCATCCCGAAAGGCAGAGCGGACCAGTGACTGGCGGTGCTGGAGAAGGTCACCGATGTGC           TTCACCACAGACCGTTTGTCAAGTCTCAGAACTCGTAACCAGGCCAGCTGCTCAGCCATCCGCAGCAG           CACAGCCAGCAGCTCCTGCAGGCGGGAGGACGCCGGGTAGGGCAGGTCCACATTTGCCAATTTACAAA           ATCGGGCAAGGGAACATGAAAGCCGATCTGCAGGCTGCAGCGACTGCCAAGCCAGGAAAGTCGCAGCA           GTGATGACGGGCAAGGGATGCCTCCCGGTCACCAGCCACGTCTCATTTGCCAGCTCCACCAACTGCAT           TGTTCGAGACAGCATCTTCTCTTTGTCTTCCACGTATTTGGCTGGCACAGAAGGTGAAGCTTGGAACA           GTTTGAAGCTGAAATAACCAAAATGAGGGTTGGATCTTAATGATATAGGGGCTGCTCTCCCACAGTGA           GGAAAGACAGCCCACTCAAGATGGGGAAGCTATTCTGCCCTCAGGAATACTCAAGCTCACTGGGCAGC           AAGTTAATAAAGGTAGTGAGAGAAAACAGGGCGTCTTCCGCTTGTTAGGGGAAGGTGGAGGGATGGAG           GAGAGCACGAACATTTATTGGGCGCCTCCCAATCACCATTATTCTGAGTGCTTTACAACGTTCTCATT           TAATCTACGTGCACGTGCACCATCTTATGTGCATGTATAGTTAAAAAACTTTCCCATAGTCATCCAGC           CAGGCAGTAACCAAGCTTCAAATACAAGGCTATTTGACAC                                           NOV10e, CG50925-02   SEQ ID NO: 266   1542 aa   MW at 164901.2kD           Protein Sequence                     MRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPE           PPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA       CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNK       ITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAAS       GLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLL       RLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAH       ALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAG       ILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRG       DFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFV       LMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMPSNLMLVDE       HLLWLAQREDKACSRIVGAIERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGG       VPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAP       PVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWA       EGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHP       VVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVG       ITLHYSSLSTLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRYILSIPALQLGRDSNAGVGNL       PRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRG       PLAQNPKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLG       ALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWPACCPPAS       PAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGE       GEPEPAGTRGNLAHRBPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGGAAGALELLSSESGSLHN       SPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHR       RSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCMKTGLWKSETTV                                     NOV10f, 2482O8844   SEQ ID NO: 267   1888 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCGAGCTGAAGCGTTTAGATCTCTCCAACAACCGGATTGGCTGTCTCACCTCCGAGACCT           TCCAGGGCCTCCCCAGGCTTCTCCGACTAAACATATCTGGAAACATCTTCTCCAGTCTGCAACCTGGG       GTCTTTGATGAGCTGCCAGCCCTTAAGGTTGTGGACTTGGGCACCGAGTTCCTGACCTGTGACTGCCA       CCTGCGCTGGCTGCTGCCCTGGGCCCAGAATCGCTCCCTGCAGCTGTCGGAACACACGCTCTGTGCTT       ACCCCAGTGCCCTGCATGCTCAGGCCCTGGGCAGCCTCCAGGAGGCCCAGCTCTGCTGCGAGGGGGCC       CTGGAGCTGCACACACACCACCTCATCCCGTCCCTACGCCAAGTGGTGTTCCAGGGGGATCGGCTGCC       CTTCCAGTGCTCTGCCAGCTACCTGGGCAACGACACCCGCATCCGCTGGTACCACAACCGAGCCCCTG       TGGAGGGTGATGAGCAGGCGGGCATCCTCCTGGCCGAGAGCCTCATCCACGACTGCACCTTCATCACC       AGTGAGCTGACGCTGTCTCACATCGGCGTGTGGGCCTCAGGCGAGTGGGAGTGCACCGTGTCCATGGC       CCAAGGCAACGCCAGCAAGAAGGTGGAGATCGTGGTGCTGGAGACCTCTGCCTCCTACTGCCCCGCCG       AGCGTGTTGCCAACAACCGCGGGGACTTCAGGTGGCCCCGAACTCTGGCTGGCATCACAGCCTACCAG       TCCTGCCTGCAGTATCCCTTCACCTCAGTGCCCCTGGGCGGGGGTGCCCCGGGCACCCGAGCCTCCCG       CCGGTGTGACCGTGCCGGCCGCTGGGAGCCAGGGGACTACTCCCACTGTCTCTACACCAACGACATCA       CCAGGGTGCTGTACACCTTCGTGCTGATGCCCATCAATGCCTCCAATGCGCTGACCCTGGCTCACCAG       CTGCGCGTGTACACAGCCGAGGCCGCTAGCTTTTCAGACATGATGGATGTAGTCTATGTGGCTCAGAT       GATCCAGAAATTTTTGGGTTATGTCGACCAGATCAAAGAGCTGGTAGAGGTGATGGTGGACATGGCCA       GCAACCTGATGCTGGTGGACGAGCACCTGCTGTGGCTGGCCCAGCGCGAGGACAAGGCCTGCAGCCGC       ATCGTGGGTGCCCTGGAGCGCATTGGGGGGGCCGCCCTCAGCCCCCATGCCCAGCACATCTCAGTGAA       TGCGAGGAACGTGGCATTGGAGGCCTACCTCATCAAGCCGCACAGCTACGTGGGCCTGACCTGCACAG       CCTTCCAGAGGAGGGAGGGAGGGGTGCCGGGCACACGGCCAGGAAGCCCTGGCCAGAACCCCCCACCT       GAGCCCGAGCCCCCAGCTGACCAGCAGCTCCGCTTCCGCTGCACCACCGGGAGGCCCAATGTTTCTCT       GTCGTCCTTCCACATCAAGAACAGCGTGGCCCTGGCCTCCATCCAGCTGCCCCCGAGTCTATTCTCAT       CCCTTCCGGCTGCCCTGGCTCCCCCGGTGCCCCCAGACTGCACCCTGCAACTGCTCGTCTTCCGAAAT       GGCCGCCTCTTCCACAGCCACAGCAACACCTCCCGCCCTGGAGCTGCTGGGCCTGGCAAGAGGCGTGG       CGTGGCCACCCCCGTCATCTTCGCAGGAACCAGTGGCTGTGGCGTGGGAAACCTGACAGAGCCAGTGG       CCGTTTCGCTGCGGCACTGGGCTGAGGGAGCCGAACCTGTGGCCGCTTGGTGGAGCCAGGAGGGGCCC       GGGGAGGCTGGGGGCTGGACCTCGGAGGGCTGCCAGCTCCGCTCCAGCCAGCCCAATGTCAGCGCCCT       GCACTGCCAGCACTTGGGCAATGTGGCCGTGCTCATGGAGCTGAGCCTCGAG                                         NOV10f, 248208844   SEQ ID NO: 268   629 aa   MW at 68481.1kD           Protein Sequence                     TGSELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCH           LRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLP       FQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMA       QGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASR       RCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQM       IQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVN       ARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSL       SSFHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRG       VATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSAL       HCQHLGNVAVLMELSLE                                     NOV10g, CG50925-03   SEQ ID NO: 269   1329 bp           DNA Sequence   ORF Start: at 7   ORF Stop: at 1324                       GGATCC CGGCTGCCCTTCCAGTGCTCTGCCAGCTACCTGGGCAACGACACCCGCATCCGCTGGTACCA           CAACCGAGCCCCTGTGGAGGGTGATGAGCAGGCGGGCATCCTCCTGGCCGAGAGCCTCATCCACGACT       GCACCTTCATCACCAGGTGGCCCCGAACTCTGGCTGGCATCACAGCCTACCAGTCCTGCCTGCAGTAT       CCCTTCACCTCAGTGCCCCTGGGCGGGGGTGCCCCGGGCACCCGAGCCTCCCGCCGGTGTGACCGTGC       CGGCCGCTGGGAGCCAGGGGACTACTCCCACTGTCTCTACACCAACGACATCACCAGGGTGCTGTACA       CCTTCGTGCTGATGCCCATCAATGCCTCCAATGCGCTGACCCTGGCTCACCAGCTGCGCGTGTACACA       GCCGAGGCCGCTAGCTTTTCAGACATGATGGATGTGGTCTATGTGGCTCAGATGATCCAGAAATTTTT       GGGTTATGTCGACCAGATCAAAGAGCTGGTAGGGGTGATGGTGGACATGGCCAGCAACCTGATGCTGG       TGGACGAGCACCTGCTGTGGCTGGCCCAGCGCGAGGACAAGGCCTGCAGCCGCATCGTGGGTGCCCTG       GAGCGCATTGGGGGGGCCGCCCTCAGCCCCCATGCCCAGCACATCTCAGTGAATGCGAGGAACGTGGC       ATTGGAGGCCTACCTCATCAAGCCGCACAGCTACGTGGGCCTGACCTGCACAGCCTTCCAGAGGAGGG       AGGGAGGGGTGCCGGGCACACGGCCAGGAAGCCCTGGCCAGAACCCCCCACCTGAGCCCGAGCCCCCA       GCTGACCAGCAGCTCCGCTTCCGCTGCACCACCGGGAGGCCCAATGTTTCTCTGTCGTCCTTCCACAT       CAAGAACAGCGTGGCCCTGGCCTCCATCCAGCTGCCCCCGAGTCTATTCTCATCCCTTCCGGCTGCCC       TGGCTCCCCCGGTGCCCCCAGACTGCACCCTGCAACTGCTCGTCTTCCGAAATGGCCGCCTCTTCCAC       AGCCACAGCAACGCCTCCCGCCCTGGAGCTGCTGGGCCTGGCAAGAGGCGTGGCGTGGCCACCCCCGT       CATCTTCGCAGGAACCAGTGGCTGTGGCGTGGGAAACCTGACAGAGTCAGTGGCCGTTTCGCTGCGGC       ACTGGGCTGAGGGAGCCGAACCTGTGGCCGCTTGGTGGAGCCAGGAGGGGCCCGGGGAGGCTGGGGGC       TGGACCTCGGAGGGCTGCCAGCTCCGCTCCAGCCAGCCCAATGTCAGCGCCCTGCACTGCCAGCACTT       GGGCAATGTGGCCGTGCTCATGGAGCTGAGCCTC GAG                                           NOV10g, CG50925-03   SEQ ID NO: 270   439 aa   MW at 47486.5kD           Protein Sequence                     RLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITRWPRTLAGITAYQSCLQYPF           TSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAE       AASFSDMMDVVYVAQMIQKFLGYVDQIKELVGVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALER       IGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEPPAD       QQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSH       SNASRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTESVAVSLRHWAEGAEPVAAWWSQEGPGEAGGWT       SEGCQLRSSQPNVSALHCQHLGNVAVLMELS                                     NOV10h, CG50925-04   SEQ ID NO: 271   60 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GAGAAGCTTCTCATGAGAGCACATTTTTCTGATGAAGATGAAAAGACGGCCTGTCCTTCT                                             NOV10h, CG50925-04   SEQ ID NO: 272   20 aa   MW at 2307.5kD           Protein Sequence                     EKLLMRAHFSDEDEKTACPS                                         NOV10i, CG50925-05   SEQ ID NO: 273   57 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     CGAGCCTCCCGCCGGTGTGACCGTGCCGGCCGCTGGGAGCCAGGGGACTACTCCCAC                                             NOV10i, CG50925-05   SEQ ID NO: 274   19 aa   MW at 2275.4kD           Protein Sequence                     RASRRCDRAGRWEPGDYSH                                         NOV10j, CG50925-06   SEQ ID NO: 275   57 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GAGCTGGTAGAGGTGATGGTGGACATGCCCAGCAACTTGATGCTGGTGGACGAGCAC                                             NOV10j, CG50925-06   SEQ ID NO: 276   19 aa   MW at 2200.6kD           Protein Sequence                     ELVEVMVDMPSNLMLVDEH                                         NOV10k, CG50925-07   SEQ ID NO: 277   66 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     AAGGCGGGCAACAGCAGGGCCTCCCTGGAGGCAGGGGAGGAGCTGAGGGGTTCCACCAGGCTCAGG                                             NOV10k, CG50925-07   SEQ ID NO: 278   22 aa   MW at 2358.6kD           Protein Sequence                     KAGNSHASLEAGEELRGSTRLR                                         NOV10l, SNP13380040   SEQ ID NO: 279   7892 bp           of CG50925-01,   ORF Start: ATG at 1   ORF Stop: TAA at 4627       DNA Sequence   SNP Pos: 2164   SNP Change: G to A                     ATGCGGGGGGCGCCCGCGCGCCTGCTGCTGCCGCTGCTGCCGTGGCTCCTGCTGCTCCTGGCGCCCGA           GGCTCGGGGCGCGCCCGGCTGCCCGCTATCCATCCGCAGCTGCAAGTGCTCGGGGGAGCGGCCCAAGG       GGCTGAGCGGCGGCGTCCCTGGCCCGGCTCGGCGGAGGGTGGTGTGCAGCGGCGGGGACCTCCCGGAG       CCTCCCGAGCCCGGCCTTCTGCCTAACGGCACCGTTACCCTTGGCAACCGTTTCTCCACTGCCCCTTG       CCCGCAGTCGGGGCTGGCCCAGTCTTTTCGATTGTGTCCAGAACAATACAGTAACGCCTCTGGTTGGG       TGAGTTCAGAGGCTGCCCGCTTCCTGACAGGACACAACTGGTCAGCCTCTGACGCTGGCCGCCCGGCC       TGCATTTTCCCCGGCCCGGTCTCCTGGAGACAGGTACCAGCTTACAACGCCGGACAGGATCAGGGTAG       CAAATATAGCTTCTATGGAGGAAAGGTCAAAGATGAGTATCTGCGTAGGTCCCCGATCTGTCGCTCTG       CTGCCGCCCTGCACACTGACACCAGTGCCCGCAGCTGGTCTGAATTTAGGCTCTTGAGCAATAACAAG       ATCACGGGGCTCCGCAATGGCTCCTTCCTGGGACTGTCACTGCTGGAGAAGCTTCTCATGAGAGCACA       TTTTTCTGATGAAGATGAAAAGACGGCCTGTCCTTCTCCAGCACCAAGGCTCTGGAGGCTGCATAGCA       AGTGCACCCTGAGCATGGCAGGCAATCAGAAGAACCAGGGCGGCAGCAGCTCACAAGAGGCAGCATCT       GGCTTGATGCCGAGTCGGCGGCTCCAGCGGGGAGAGGTTGAGGGCCTCTGCACTTGCCTCTGCACGGA       CCTGAGGAACAACATCATCAGCACAGTGCAGCCGGGCGCCTTCCTGGGCCTGGGGGAGCTGAAGCGTT       TAGATCTCTCCAACAACCGGATTGGCTGTCTCACCTCCGAGACCTTCCAGGGCCTCCCCAGGCTTCTC       CGACTAAACATATCTGGAAACATCTTCTCCAGTCTGCAACCTGGGGTCTTTGATGAGCTGCCAGCCCT       TAAGGTTGTGGACTTGGGCACCGAGTTCCTGACCTGTGACTGCCACCTGCGCTGGCTGCTGCCCTGGG       CCCAGAATCGCTCCCTGCAGCTGTCGGAACACACGCTCTGTGCTTACCCCAGTGCCCTGCATGCTCAT       GCCCTGGGCAGCCTCCAGGAGGCCCAGCTCTGCTGCGAGGGGGCCCTGGAGCTGCACACACACCACCT       CATCCCGTCCCTACGCCAAGTGGTGTTCCAGGGGGATCGGCTGCCCTTCCAGTGCTCTGCCAGCTACC       TGGGCAACGACACCCGCATCCGCTGGTACCACAACCGAGCCCCTGTGGAGGGTGATGAGCAGGCGGGC       ATCCTCCTGGCCGAGAGCCTCATCCACGACTGCACCTTCATCACCAGTGAGCTGACGCTGTCTCACAT       CGGCGTGTGGGCCTCAGGCGAGTGGGAGTGCACCGTGTCCATGGCCCAAGGCAACGCCAGCAAGAAGG       TGGAGATCGTGGTGCTGGAGACCTCTGCCTCCTACTGCCCCGCCGAGCGTGTTGCCAACAACCGCGGG       GACTTCAGGTGGCCCCGAACTCTGGCTGGCATCACAGCCTACCAGTCCTGCCTGCAGTATCCCTTCAC       CTCAGTGCCCCTGGGCGGGGGTGCCCCGGGCACCCGAGCCTCCCGCCGGTGTGACCGTGCCGGCCGCT       GGGAGCCAGGGGACTACTCCCACTGTCTCTACACCAACGACATCACCAGGGTGCTGTACACCTTCGTG       CTGATGCCCATCAATGCCTCCAATGCGCTGACCCTGGCTCACCAGCTGCGCGTGTACACAGCCGAGGC       CGCTAGCTTTTCAGACATGATGGATGTAGTCTATGTGGCTCAGATGATCCAGAAATTTTTGGGTTATG       TCGACCAGATCAAAGAGCTGGTAGAGGTGATGGTGGACATGCCCAGCAACTTGATGCTGGTGGACGAG       CACCTGCTGTGGCTGGCCCAGCGCGAGGACAAGGCCTGCAGCCGCATCGTGGGTGCCATAGAGCGCAT       TGGGGGGGCCGCCCTCAGCCCCCATGCCCAGCACATCTCAGTGAATGCGAGGAAC   A   TGGCATTGGAGG       CCTACCTCATCAAGCCGCACAGCTACGTGGGCCTGACCTGCACAGCCTTCCAGAGGAGGGAGGGAGGG       GTGCCGGGCACACGGCCAGGAAGCCCTGGCCAGAACCCCCCACCTGAGCCCGAGCCCCCAGCTGACCA       GCAGCTCCGCTTCCGCTGCACCACCGGGAGGCCCAATGTTTCTCTGTCGTCCTTCCACATCAAGAACA       CCGGTGCCCCCAGACTGCACCCTGCAACTGCTCGTCTTCCGAAATGGCCGCCTCTTCCACAGCCACAG       CAACACCTCCCGCCCTGGAGCTGCTGGGCCTGGCAAGAGGCGTGGCGTGGCCACCCCCGTCATCTTCG       CAGGAACCAGTGGCTGTGGCGTGGGAAACCTGACAGAGCCAGTGGCCGTTTCGCTGCGGCACTGGGCT       GAGGGAGCCGAACCTGTGGCCGCTTGGTGGAGCCAGGAGGGGCCCGGGGAGGCTGGGGGCTGGACCTC       GGAGGGCTGCCAGCTCCGCTCCAGCCAGCCCAATGTCAGCGCCCTGCACTGCCAGCACTTGGGCAATG       TGGCCGTGCTCATGGAGCTGAGCGCCTTTCCCAGGGAGGTGGGGGGCGCCGGGGCAGGGCTGCACCCC       GTGGTATACCCCTGCACGGCCTTGCTGCTGCTCTGCCTCTTCGCCACCATCATCACCTACATCCTCAA       CCACAGCTCCATCCGTGTGTCCCGGAAAGGCTGGCACATGCTGCTGAACTTGTGCTTCCACATAGCCA       TGACCTCTGCTGTCTTTGCGGGGGGCATCACACTCACCAACTACCAGATGGTCTGCCAGGCGGTGGGC       ATCACCCTGCACTACTCCTCCCTATCCACGCTGCTCTGGATGGGCGTGAAGGCGCGAGTGCTCCATAA       GGAGCTCACCTGGAGGGCACCCCCTCCGCAAGAAGGGGACCCCGCTCTGCCTACTCCCAGTCCTATGC       TCCGGTACATACTTTCAATTCCAGCTTTGCAATTGGGGAGGGACTCCAACGCAGGCGTAGGAAACCTC       CCAAGGTTCTATTTGATCGCTGGAGGGATTCCACTCATTATCTGTGGCATCACAGCTGCAGTCAACAT               CCACAACTACCGGGACCACAGCCCCTACTGCTGGCTGGTGTGGCGTCCAAGCCTTGGCGCCTTCTACA       TCCCTGTGGCTTTGATTCTGCTCATCACCTGGATCTATTTCCTGTGCGCCGGGCTACGCTTACGGGGT       CCTCTGGCACAGAACCCCAAGGCGGGCAACAGCAGGGCCTCCCTGGAGGCAGGGGAGGAGCTGAGGGG       TTCCACCAGGCTCAGGGGCAGCGGCCCCCTCCTGAGTGACTCAGGTTCCCTTCTTGCTACTGGGAGCG       CGCGAGTGGGGACGCCCGGGCCCCCGGAGGATGGTGACAGCCTCTATTCTCCGGGAGTCCAGCTAGGG       GCGCTGGTGACCACGCACTTCCTGTACTTGGCCATGTGGGCCTGCGGGGCTCTGGCAGTGTCCCAGCG       CTGGCTGCCCCGGGTGGTGTGCAGCTGCTTGTACGGGGTGGCAGCCTCCGCCCTGGGCCTCTTCGTCT       TCACTCACCACTGTGCCAGGCGGAGGGACGTGAGAGCCTCGTGGCGCGCCTGCTGCCCCCCTGCCTCT       CCCGCGGCCCCCCATGCCCCGCCCCGGGCCCTGCCCGCCGCCGCAGAGGACGGTTCCCCGGTGTTCGG       GGAGGGGCCCCCCTCCCTCAAGTCCTCCCCAAGCGGCAGCAGCGGCCATCCGCTGGCTCTGGGCCCCT       GCAAGCTCACCAACCTGCAGCTGGCCCAGAGTCAGGTGTGCGAGGCGGGGGCGGCGGCCGGCGGGGAA       GGAGAGCCGGAGCCGGCGGGCACCCGGGGAAACCTCGCCCACCGCCACCCCAACAACGTGCACCACGG       GCGTCGGGCGCACAAGAGCCGGGCCAAGGGACACCGCGCGGGGGAGGCCTGCGGCAAGAACCGGCTCA       AGGCCCTGCGCGGGGGCGCGGCGGGGGCGCTGGAACTGCTGTCCAGCGAGAGCGGTAGTCTGCACAAC       AGCCCCACCGACAGCTACCTGGGCAGCAGCCGCAACAGCCCGGGCGCCGGCCTGCAGCTGGAAGGCGA       GCCCATGCTCACGCCGTCCGAGGGCAGCGACACCAGCGCCGCGCCGCTTTCTGAGGCGGGCCGGGCAG       GCCAGCGCCGCAGCGCCAGCCGCGACAGTCTCAAGGGCGGCGGCGCGCTGGAGAAGGAGAGCCATCGC       CGCTCGTACCCGCTCAACGCCGCCAGCCTAAACGGCGCCCCCAAGGGGGGCAAGTACGACGACGTCAC       CCTGATGGGCGCGGAGGTAGCCAGCGGCGGCTGCATGAAGACCGGACTCTGGAAGAGCGAAACTACCG       TC TAA   GGTGGGGCGGGCGACGCGGTAGACGGGTTGGCCACGCGGCTCGTTCCCCCGCTCCTCGGGGCC           CTCCAAGGTGTCTCCGTAGTCAGCAGGTTGGAGGCAGAGGAGCCGATGGCTGGAGGAAGCCCACAGGC           GGATGTTCCCCACTTGCCTAGAGGGCATCCCTCTGGGGTAGCGACAGACAATCCCAGAAACACGCATA           ATACATTTCCGTCCAGCCCGGGGCAGTCTGACTGTCGGTGCCCTCCCAGGAACGGGGAAGGCCTCCGT           CTGTGTGAAAGGGCACAGCACATCCCAGGTGCACCCTCCCCAAGTACTCCCACCCCGCCTACTGTCCA           TGCGGCCTCACTGGGGGCCATCAGCCTCACCAGCAAAGCAGAGATGAGAGCGTGGGAACTGTGTTCTT           TCCTCCCTGCCCTCTACTGATTTCAGCCCAGCCCCTGCCTAGATCCTAGGTCCCTTTTCCTCCCGAGT           TTGGCTGGCACGAGAGCTAGCCCAGCACATGAAGCAGGTGATGTTAAGTCACAAGGTGCTGCTTTTCA           GATCCACTATGCAAGAGGGGAGGGTGGGGCCACGTGAAAGGCAGCTCTAGACATCAACCAGTCCTGGG           GGAGGGGAGTGGGAACCGGGCACAACTAGGAACAATGCCACCATTCCCACAGGAGTGGTACTTAAACC           AGACAGCAGGGTTCAGAGGTGGCACACCGGGACAAAGCTGAGGCCCTGCACCTCAACAGCTGACTGCC           AGGTGCCTGTGGGTGAACTGAGGGGAGTAGAGGGAGAGGGCAGGTGGAACTGGGGCAGAATCTAGTCA           TGCCCTAAAGCTAGTCCTGTAAACAATGGTGCCCCAGAAAGCTGCAGGTGGTGTTTGGAGAAGCAGTT           ACTTTTCAGTTACAAGACCCATCTCCCTAGTCTCAGCCTTACAACACCACGGGACTAAGGAAGAGCAC           TTCCTTGCCTCCGTAAGGCCAGAGGAAGAACCATCCCAATCATTTGATCTCCAGCTCCACAGTAGAGA           GAAACCTACAAAATGTCAAACCAGCTTCCCGACTCCCAGGAGCTCAAGCCAAGCCCAGAGGCAGTGGC           TGGGGTCCCTGCAGGTCATGAGGGGCCTATGCCTTTACTCCTTTTAAACACCAGCACCCGTCTTTTCC           CCAACCTAAAACCAACCACCAGCATTTCACTACAGGACCAAATGGAAACCGAGGGAACCCTGGGTCTT           GGGAAGAACAACAGGAAACCAAGGTCTGACCTAGGGTTCCCTCCCAGTCTTCACATCACTCTGGCCTC           ATCACCAAGGTGACAGAGGACACAGGGGAGGGGGAAAACCCACACACACTCCTTGGAATGGGTCCTGT           TATTTATGCTTGCTGCACAGACATATTAGAAGAAAAAAAAAAAGCTTTGTATTATTCTTCCACATATG           CTGGCTGCTGTTTACACACCCTGCCAATGCCTTAGCACTGGAGAGCTTTTTGCAATATGCTGGGGAAA           GGGGAGGGAGGGAATGAAAGTGCCAAAGAAAACATGTTTTTAAGAACTCGGGTTTTATACAATAGAAT           GTTTTCTAGCAGATGCCTCTTGTTTTAATATATTAAAATTTTGCAAAGCCCTTTGAGCTACTGCCTTA           GTCTACCCACTGTCCTTTTGTTATGAGGTAGAGGATCTCATGACACCATACACACAAACCCATCATTG           CCTGTGAATGCACGTAGGGCCAGAATTCCCCAGTTCCCGCTCCTCTGAGGGTTGATACTGCTGGGAAT           GCCAACCACTCCACAAGCAGAGGGAAGCCCCCTCAGGCCTGCAGGAGGAGCCGCAGCAGTGTGTCCAA           TTCAAACCAGCAGCAAAGAGCCTGACATTTTCCCATCCATCTATGAGGAAAGCCATCTCACAGAACAT           GGACATAGGCAACTTGCTCTCCCACACCAAGGGATGGGAATCTCTCCTACCTATAGTCATCCCTGCAC           TCCTGACTTTACTCCAGGACCCAGGGTCCAACTAATGGCAGAGCCCCTCTTGGTTCCTTCAAACAAGA                   AAAGCAATACCTACGGACTGGTGTACACTTCCATCCTTGGTTATAACAGGAATGTTATCAAGCTGTCA           GAACAGGATGAAGTGCTCCCAGTGGATATCCATCAGGGAGGGTTAGGGACACTCGTGGCAGCCTGTCT           AGCAGCCTGGGCTCTCTGAAAGTCCCTAACTTCCTGAGGGGTACGCAAATACTGTTCTATTTCACTAT           CAGAAATGTTCTCATCTCCAGTGACAGTGGAGACAGGGGGTACAGGGCAGATCCGCTTCGGGGACTTC           AACATGCAGGGTGGCAAGAGAAGGGCAGGACTGGCCGGCCGCTTCCCCTGGGGTAAACCTAAGGAATT           ATTTCCCACCTCCCCTTCTCCTTGCCCCTGTCCCCACCCCGGTGGCTCCTTCTCTCGGGTCTCCACTT           CTGCTGTCCCATCCCGAAAGGCAGAGCGGACCAGTGACTGGCGGTGCTGGAGAAGGTCACCGATGTGC           TTCACCACAGACCGTTTGTCAAGTCTCAGAACTCGTAACCAGGCCAGCTGCTCAGCCATCCGCAGCAG           CACAGCCAGCAGCTCCTGCAGGCGGGAGGACGCCGGGTAGGGCAGGTCCACATTTGCCAATTTACAAA           ATCGGGCAAGGGAACATGAAAGCCGATCTGCAGGCTGCAGCGACTGCCAAGCCAGGAAAGTCGCAGCA           GTGATGACGGGCAAGGGATGCCTCCCGGTCACCAGCCACGTCTCATTTGCCAGCTCCACCAACTGCAT           TGTTCGAGACAGCATCTTCTCTTTGTCTTCCACGTATTTGGCTGGCACAGAAGGTGAAGCTTGGAACA           GTTTGAAGCTGAAATAACCAAAATGAGGGTTGGATCTTAATGATATAGGGGCTGCTCTCCCACAGTGA           GGAAAGACAGCCCACTCAAGATGGGGAAGCTATTCTGCCCTCAGGAATACTCAAGCTCACTGGGCAGC           AAGTTAATAAAGGTAGTGAGAGAAAACAGGGCGTCTTCCGCTTGTTAGGGGAAGGTGGAGGGATGGAG           GAGAGCACGAACATTTATTGGGCGCCTCCCAATCACCATTATTCTGAGTGCTTTACAACGTTCTCATT           TAATCTACGTGCACGTGCACCATCTTATGTGCATGTATAGTTAAAAAACTTTCCCATAGTCATCCAGC           CAGGCAGTAACCAAGCTTCAAATACAAGGCTATTTGACACCAACAGCCTCTACTTTCAACGTTATTTA           TCAG                                           NOV10l, SNP13380040   SEQ ID NO: 280   1542 aa   MW at 164933.2kD           of CG50925-01,   SNP Pos: 722   SNP Change: Val to Met       Protein Sequence                     MRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPE           PPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA       CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNK       ITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAAS       GLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLL       RLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAH       ALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAG       ILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRG       DFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFV       LMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMPSNLMLVDE       HLLWLAQREDKACSRIVGAIERIGGAALSPHAQHISVNARN   M   ALEAYLIKPHSYVGLTCTAFQRREGG       VPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAP       PVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWA       EGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHP       VVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVG       ITLHYSSLSTLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRYILSIPALQLGRDSNAGVGNL       PRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRG       PLAQNPKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLG       ALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPAS       PAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGE       GEPEPAGTRGNLAHRHPNNVHHGRRAHKSPAKGHRAGEACGKNRLKALRGGAAGALELLSSESGSLHN       SPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHR       RSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCMKTGLWKSETTV                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 10B.  
               TABLE 10B                       Comparison of the NOV10 protein sequences.                                            NOV10a   ------------------------------------------------------------           NOV10b   MRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVV       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   ------------------------------------------------------------       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   ------------------------------------------------------------       NOV10b   CSGGDLPEPPEPGLLPNGTVTLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSET       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   ------------------------------------------------------------       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   ------------------------------------------------------------       NOV10b   FQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQ       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   ------------------------------------------------------------       NOV10f   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   ------------------------------------------------------------       NOV10b   LSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSAS       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   ------------------------------------------------------------       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   ------------------------------------------------------------       NOV10b   YLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVS       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   ------------------------------------------------------------       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   ------------------------------------------------------------       NOV10b   MAQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLG       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   ------------------------------------------------------------       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   ------------------------------------------------------------       NOV10b   GGAPGTRASRRCDRAGRWESGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYT       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   ------------------------------------------------------------       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   ------------------------------------------------------------       NOV10b   AEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLNLVDEHLLWLAQREDKA       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   ------------------------------------------------------------       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   ------------------------------------------------------------       NOV10b   CSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGT       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   ------------------------------------------------------------       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   ------------------------------------------------------------       NOV10b   RPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPA       NOV10c   ------------------------------------------------------------       NOV10d   --------------------------------------------TGSAPGCPLSIRSCKC       NOV10e   ------------------------------------------MRGAPARLLLPLLPWLLL       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   ------------------------------------------------------------       NOV10b   ALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNL       NOV10c   ------------------------------------------------------------       NOV10d   SGERAKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLG       NOV10e   LLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPNG       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   ------------------------------------------------------------       NOV10b   TEPVAVSLRHWAEGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAV       NOV10c   ------------------------------------------------------------       NOV10d   LSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGN       NOV10e   TVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACI       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   -----------MRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSG       NOV10b   LMELSAFPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNNSSIRVSRKGWHMLLNL       NOV10c   ------------------------------------------------------------       NOV10d   IFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHA       NOV10e   FPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFR       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   GVPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSN       NOV10b   CFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPP       NOV10c   ------------------------------------------------------------       NOV10d   QALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHDEA       NOV10e   LLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGN       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   ASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVK       NOV10b   QEGDPALPTPSPMLRYILSIPALQLGRDSNAGVGNLPRFYLIAGGIPLIICGITAAVNIH       NOV10c   ----------------------------------------------------TGSELKRL       NOV10d   PVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVL       NOV10e   QKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRL       NOV10f   ----------------------------------------------------TGSELKRL       NOV10g   -------------------------------RLPFQCSASYLGNDTRIRWYHNHAPVEGD       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   DEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFS       NOV10b   NYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKAGNSRASLE       NOV10c   DLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCH       NOV10d   ETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRA       NOV10e   DLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCH       NOV10f   DLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCH       NOV10g   EQAGILLAESLIHDCTFITRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTHASRRCDRA       NOV10h   --------------------------------------------------EKLLMRAHFS       NOV10i   ---------------------------------------------------RASRRCDRA       NOV10j   --------------------------------------------------ELVEVMVDMP       NOV10k   --------------------------------------------------KAGNSRASLE               NOV10a   DEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLC       NOV10b   AGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHFL       NOV10c   LRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCELE---------------       NOV10d   GRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDNMDVVYV       NOV10e   LRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIPSLRQV       NOV10f   LRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQV       NOV10g   GRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYV       NOV10h   DEDEKTACPS--------------------------------------------------       NOV10i   GRWEPGDYSH--------------------------------------------------       NOV10j   SNLMLVDEH---------------------------------------------------       NOV10k   AGEELRGSTRLR------------------------------------------------               NOV10a   TCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIF       NOV10b   YLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARPPDVRASWRACCPPAS       NOV10c   ------------------------------------------------------------       NOV10d   AQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAA       NOV10e   VFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSH       NOV10f   VFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSH       NOV10g   AQMIQKFLGYVDQIKELVGVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAA       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   SSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHA       NOV10b   PAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCE       NOV10c   ------------------------------------------------------------       NOV10d   LSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEP       NOV10e   IGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAY       NOV10f   IGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAY       NOV10g   LSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEP       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   LGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNEAPV       NOV10b   AGAAAGGEGEPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGGA       NOV10c   ------------------------------------------------------------       NOV10d   PADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLL       NOV10e   QSCLQYPFTSVPLGGGAPGTRASRRCDEAGRWEPGDYSHCLYTNDITRVLYTFVLMPINA       NOV10f   QSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINA       NOV10g   PADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLL       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   EGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLET       NOV10b   AGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGR       NOV10c   ------------------------------------------------------------       NOV10d   VFRTGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGA       NOV10e   SNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMPSNLMLV       NOV10f   SNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLV       NOV10g   VFRNGRLFHSHSNASRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTESVAVSLRHWAEGA       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   SASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRcDRAGR       NOV10b   AGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCMK       NOV10c   ------------------------------------------------------------       NOV10d   EPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAG       NOV10e   DEHLLWLAQREDKACSRIVGAIERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLT       NOV10f   DEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLT       NOV10g   EPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELS----------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   WEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQ       NOV10b   TGLWKSETTV--------------------------------------------------       NOV10c   ------------------------------------------------------------       NOV10d   AGLLEG------------------------------------------------------       NOV10e   CTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALA       NOV10f   CTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALA       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   MIQKFLGYVDQIKELVEVMVDMPSNLMLVDEHLLWLAQREDKACSRIVGAIERIGGAALS       NOV10b   ------------------------------------------------------------       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   SIQLPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATP       NOV10f   SIQLPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATP       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   PHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEPPA       NOV10b   ------------------------------------------------------------       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   VIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPN       NOV10f   VIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPN       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   DQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLLVF       NOV10b   ------------------------------------------------------------       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   VSALHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSS       NOV10f   VSALHCQHLGNVAVLMELSLE---------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   RNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEP       NOV10b   ------------------------------------------------------------       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   IRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKA       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   VAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAG       NOV10b   ------------------------------------------------------------       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   RVLHKELTWHAPPPQEGDPALPTPSPMLRYILSIPALQLGRDSNAGVGNLPRFYLIAGGI       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   LHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITL       NOV10b   ------------------------------------------------------------       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   PLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPL       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   TNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRYI       NOV10b   ------------------------------------------------------------       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   AQNPKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYS       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   LSIPALQLGRDSNAGVGNLPRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSL       NOV10b   ------------------------------------------------------------       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   PGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRR       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   GAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKAGNSRASLEAGEELRGSTRLRGSGPL       NOV10b   ------------------------------------------------------------       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NQV10e   DVEASWRACCPPASPAAPHAPPRAIPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPC       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   LSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRWL       NOV10b   ------------------------------------------------------------       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   KLTNLQLAQSQVCEAGAAAGGEGEPEPAGTRGNLAHRHPNNVHHGRPAHKSRAKGHRAGE       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   PRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPAAPHAPPRALPAAAED       NOV10b   ------------------------------------------------------------       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   ACGKNRLKALRGGAAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSE       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   GSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGEGEPEPAGTR       NOV10b   ------------------------------------------------------------       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   GSDTSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPKGGKYDDV       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   GNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGGAAGALELLSSESGSLHNS       NOV10b   ------------------------------------------------------------       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   TLMGAEVASGGCMKTGLWKSETTV------------------------------------       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   PTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGRAGQRRSASRDSLKGGGA       NOV10b   ------------------------------------------------------------       NOV10c   ------------------------------------------------------------       NOV10d   ------------------------------------------------------------       NOV10e   ------------------------------------------------------------       NOV10f   ------------------------------------------------------------       NOV10g   ------------------------------------------------------------       NOV10h   ------------------------------------------------------------       NOV10i   ------------------------------------------------------------       NOV10j   ------------------------------------------------------------       NOV10k   ------------------------------------------------------------               NOV10a   LEKESHRRSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCMKTGLWKSETTV       NOV10b   -----------------------------------------------------       NOV10c   -----------------------------------------------------       NOV10d   -----------------------------------------------------       NOV10e   -----------------------------------------------------       NOV10f   -----------------------------------------------------       NOV10g   -----------------------------------------------------       NOV10h   -----------------------------------------------------       NOV10i   -----------------------------------------------------       NOV10j   -----------------------------------------------------       NOV10k   -----------------------------------------------------               NOV10a   (SEQ ID NO: 258)       NOV10b   (SEQ ID NO: 260)       NOV10c   (SEQ ID NO: 262)       NOV10d   (SEQ ID NO: 264)       NOV10e   (SEQ ID NO: 266)       NOV10f   (SEQ ID NO: 268)       NOV10g   (SEQ ID NO: 270)       NOV10h   (SEQ ID NO: 272)       NOV10i   (SEQ ID NO: 274)       NOV10j   (SEQ ID NO: 276)       NOV10k   (SEQ ID NO: 278)                  
 
      Further analysis of the NOV10a protein yielded the following properties shown in Table 10C.  
               TABLE 10C                       Protein Sequence Properties NOV10a                                        SignalP analysis:   Cleavage site between residues 27 and 28       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 7; pos. chg 2; neg. chg 0           H-region:   length 15; peak value 9.66           PSG score:   5.26                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 5.33           possible cleavage site: between 26 and 27                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 26)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 27           Tentative number of TMS(s) for the threshold 0.5: 5                                 INTEGRAL   Likelihood =   Transmembrane 958-974               −7.91           INTEGRAL   Likelihood =   Transmembrane  988-1004               −1.22           INTEGRAL   Likelihood =   Transmembrane 1093-1109               −6.26           INTEGRAL   Likelihood =   Transmembrane 1136-1152               −8.17           INTEGRAL   Likelihood =   Transmembrane 1252-1268               −3.50                             PERIPHERAL   Likelihood = 1.11 (at 1223)                         ALOM score: −8.17 (number of TMSs: 5)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 13           Charge difference: −2.0 C(1.0)-N(3.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 3a                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   2   Hyd Moment(75):   12.41           Hyd Moment(95):   9.21   G content:    1           D/E content:   1   S/T content:    0                         Score: −2.41       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 68 RRV|VC                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: PGPARRR (3) at 52           pat7: PARRRVV (5) at 54           pat7: PGKRRGV (5) at 849           bipartite: none           content of basic residues: 9.1%           NLS Score: 0.65       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: RGAP                 none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 55.5       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         43.5%: endoplasmic reticulum           34.8%: nuclear           13.0%: mitochondrial            4.3%: cytoplasmic            4.3%: peroxisomal                 &gt;&gt; prediction for CG50925-01 is end (k = 23)                  
 
      A search of the NOV10a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 10D.  
               TABLE 10D                          Geneseq Results for NOV10a                                         NOV10a                       Residues/   Identities/       Geneseq   Protein/Organism/Length   Match   Similarities for the   Expect       Identifier   [Patent #, Date]   Residues   Matched Region   Value               ABU54447   Human tumour endothelial marker   263 . . . 1542   1231/1292 (95%)   0.0           TEM 9 -  Homo sapiens , 1331 aa.    63 . . . 1331   1236/1292 (95%)           [WO200283874-A2, 24-OCT-2002]       ABU54432   Human tumour endothelial marker   263 . . . 1542   1231/1292 (95%)   0.0           TEM 5 -  Homo sapiens , 1331 aa.    63 . . . 1331   1236/1292 (95%)           [WO200283874-A2, 24-OCT-2002]       AAU74824   Human REPTR 7 protein -  Homo     263 . . . 1542   1231/1292 (95%)   0.0             sapiens , 1331 aa. [WO200198354-A2,    63 . . . 1331   1236/1292 (95%)           27-DEC-2001]       ABB90740   Human Tumour Endothelial Marker   263 . . . 1542   1231/1292 (95%)   0.0           polypeptide SEQ ID NO 212 -  Homo      63 . . . 1331   1236/1292 (95%)             sapiens , 1331 aa. [WO200210217-A2,           07-FEB-2002]       ABB90725   Human Tumour Endothelial Marker   263 . . . 1542   1231/1292 (95%)   0.0           polypeptide SEQ ID NO 188 -  Homo      63 . . . 1331   1236/1292 (95%)             sapiens , 1331 aa. [WO200210217-A2,           07-FEB-2002]                  
 
      In a BLAST search of public sequence databases, the NOV10a protein was found to have homology to the proteins shown in the BLASTP data in Table 10E.  
               TABLE 10E                          Public BLASTP Results for NOV10a                                         NOV10a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q96PE1   Tumor endothelial marker 5   263 . . . 1542   1231/1292 (95%)   0.0           precursor -  Homo sapiens      63 . . . 1331   1236/1292 (95%)           (Human), 1331 aa.       Q8TEM3   FLJ00170 protein -  Homo sapiens     263 . . . 1542   1230/1292 (95%)   0.0           (Human), 1310 aa (fragment).    42 . . . 1310   1235/1292 (95%)       Q91ZV8   Tumor endothelial marker 5   280 . . . 1542   1083/1266 (85%)   0.0           precursor -  Mus musculus      92 . . . 1329   1140/1266 (89%)           (Mouse), 1329 aa.       Q9P1Z7   KIAA1531 protein -  Homo sapiens     923 . . . 1542    587/620 (94%)   0.0           (Human), 1206 aa (fragment).   615 . . . 1206    589/620 (94%)       Q8N3R1   Hypothetical protein -  Homo     1031 . . . 1542     489/512 (95%)   0.0             sapiens  (Human), 489 aa    1 . . . 489    489/512 (95%)           (fragment).                  
 
      PFam analysis predicts that the NOV10a protein contains the domains shown in the Table 10F.  
               TABLE 10F                          Domain Analysis of NOV10a                                             Identities/                       Similarities           Pfam   NOV10a   for the   Expect           Domain   Match Region   Matched Region   Value                                                 LRR   314 . . . 337   10/25 (40%)   0.0086                   20/25 (80%)           LRR   338 . . . 361   10/25 (40%)   0.15                   20/25 (80%)           LRRCT   371 . . . 421   19/54 (35%)   1.3e-08                   40/54 (74%)           HRM   531 . . . 600   24/92 (26%)   0.0088                   48/92 (52%)           GPS   887 . . . 939   15/55 (27%)   0.0041                   34/55 (62%)           7tm_2    950 . . . 1280   65/359 (18%)    0.0032                   207/359 (58%)                       
 
     Example 11  
      The NOV11 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 11A.  
               TABLE 11A                       NOV11 Sequence Analysis                                                NOV11a, CG51027-06   SEQ ID NO: 281   1271 bp           DNA Sequence   ORF Start: ATG at 48   ORF Stop: TAG at 1056                       GCGCAGTGTGCTGGAATTCGCCCTTCCTCCGTGCCGCCTCTGCCGCG   ATG CCCCCCCCTGCGCCCGGC           GCCCGGCTCCGGCTTCTCGCCGCCGCCGCCCTGGCCGGCTTGGCCGTCATCAGCCGAGGGCTGCTCTC       CCAGAGCCTGGAGTTCAACTCTCCTGCCGACAACTACACAGTGTGTGAAGGTGACAACGCCACCCTCA       GCTGCTTCATCGACGAGCACGTGACCCGCGTGGCCTGGCTGAACCGCTCCAACATCCTGTATGCCGGC       AATGACCGCTGGACCAGCGACCCGCGGGTGCGGCTGCTCATCAACACCCCCGAGGAGTTCTCCATCCT       CATCACCGAGGTGGGGCTCGGCGACGAGGGCCTCTACACCTGCTCCTTCCAGACCCGCCACCAGCCGT       ACACCACTCAGGTCTACCTCATTGTCCACGTCCCTGCCCGCATTGTGAACATCTCGTCGCCTGTGATG       GTGAATGAGGGGGGCAATGTGAACCTGCTTTGCCTGGCCGTGGGGCGGCCAGAGCCCACGGTCACCTG       GAGACAGCTCCGAGACGGCTTCACCTCGGAGGGAGAGATCCTGGAGATCTCTGACATCCAGCGGGGCC       AGGCCGGGGAGTATGAGTGCGTGACTCACAACGGGGTTAACTCGGCGCCCGACAGCCGCCGCGTGCTG       GTCACAGTCAACTATCCTCCGACCATCACGGACGTGACCAGCGCCCGCACCGCGCTGGGCCGGGCCGC       CCTCCTGCGCTGCGAAGCCATGGCGGTTCCCCCCGCGGATTTCCAGTGGTATAAGGATGACAGACTGC       TGAGCAGCGGCACGGCCGAAGGCCTGAAGGTGCAGATGGAGCGCACCCGCTCGATGCTTCTCTTTGCC       AACGTGAGCGCCCGGCATTACGGCAACTATACGTGTTGCGCCGCCAACCGACTGGGAGCGTCCAGCGC       CTCCATGCGGCTCCTGTGCCCAGGATCCCTGGAGAACTCAGCCCCGAGGCCCCCAGGGCTCCTGGCCC       TCCTCTCCGCCCTGGGCTGGCTGTGGTGGAGAATG TAG   GCGCAACCCAGTGGAGCTCGCCTCCCCCTG           CAGGGGGCCTCAGGCCAAGAGTGAGAGAAAAGGGGGAGCAAGAGCCCTGGGTCTCGTGGGGGCAGAAC           GGCTCTCGGCCACCAAGGAAGAAGAGAAGAGGAGAAAGAGGAGGAGGCAGAGGAAGAAAGATCTTTAG           AGAACCCATCACTGTGAGGGATAACGCAAAATTATGCATCTTTCTAC                                           NOV11a, CG51027-06   SEQ ID NO: 282   336 aa   MW at 36748.4kD           Protein Sequence                     MPPPAPGARLRLLAAAALAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNR           SNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIV       NISSPVMVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSA       PDSRRVLVTVNYPPTITDVTSARTALGRAALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQMERT       RSMLLFANVSARHYGNYTCCAANRLGASSASMRLLCPGSLENSAPRPPGLIJALLSALGWLWWRM                                     NOV11b, 278391205   SEQ ID NO: 283   1033 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAAGCTTCCCACCATGCCCCCCCCTGCGCCCGGGGCCCGGCTCCGGCTTCTCGCCGCCGCCGCCC           TGGCCGGCTTGGCCGTCATCAGCCGAGGGCTGCTCTCCCAGAGCCTGGAGTTCAACTCTCCTGCCGAC       AACTACACAGTGTGTGAAGGTGACAACGCCACCCTCAGCTGCTTCATCGACGAGCACGTGACCCGCGT       GGCCTGGCTGAACCGCTCCAACATCCTGTATGCCGGCAATGACCGCTGGACCAGCGACCCGCGGGTGC       GGCTGCTCATCAACACCCCCGAGGAGTTCTCCATCCTCATCACCGAGGTGGGGCTCGGCGACGAGGGC       CTCTACACCTGCTCCTTCCAGACCCGCCACCAGCCGTACACCACTCAGGTCTACCTCATTGTCCACGT       CCCTGCCCGCATTGTGAACATCTCGTCGCCTGTGACGGTGAATGAGGGGGGCAATGTGAACCTGCTTT       GCCTGGCCGTGGGGCGGCCAGAGCCCACGGTCACCTGGAGACAGCTCCGAGACGGCTTCACCTCGGAG       GGAGAGATCCTGGAGATCTCTGACATCCAGCGGGGCCAGGCCGGGGAGTATGAGTGCGTGACTCACAA       CGGGGTTAACTCGGCGCCCGACAGCCGCCGCGTGCTGGTCACAGTCAACTATCCTCCGACCATCACGG       ACGTGACCAGCGCCCGCACCGCGCTGGGCCGGGCCGCCCTCCTGCGCTGCGAAGCCATGGCGGTTCCC       CCCGCGGATTTCCAGTGGTACAAGGATGACAGACTGCTGAGCAGCGGCACGGCCGAAGGCCTGAAGGT       GCAGACGGAGCGCACCCGCTCGATGCTTCTCTTTGCCAACGTGAGCGCCCGGCATTACGGCAACTATA       CGTGTCGCGCCGCCAACCGACTGGGAGCGTCCAGCGCCTCCATGCGGCTCCTGCGCCCAGGATCCCTG       GAGAACTCAGCCCCGAGGCCCCCAGGGCTCCTGGCCCTCCTCTCCGCCCTGGGCTGGCTGTGGTGGAG       AATGCTCGAGGGC                                         NOV11b, 278391205   SEQ ID NO: 284   344 aa   MW at 37634.3kD           Protein Sequence                     TKLPTMPPPAPGARLRLLAAAALAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRV           AWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHV       PARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHN       GVNSAPDSPRVLVTVNYPPTITDVTSARTALGRAALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKV       QTERTRSMLLFANVSARHYGNYTCRAANRLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWR       MLEG                                     NOV11c, 278391050   SEQ ID NO: 285   976 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAAGCTTCTGGCCGGCTTGGCCGTCATCAGCCGAGGGCTGCTCTCCCAGAGCCTGGAGTTCAACT           CTCCTGCCGACAACTACACAGTGTGTGAAGGTGACAACGCCACCCTCAGCTGCTTCATCGACGAGCAC       GTGACCCGCGTGGCCTGGCTGAACCGCTCCAACATCCTGTATGCCGGCAATGACCGCTGGACCAGCGA       CCCGCGGGTGCGGCTGCTCATCAACACCCCCGAGGAGTTCTCCATCCTCATCACCGAGGTGGGGCTCG       GCGACGAGGGCCTCTACACCTGCTCCTTCCAGACCCGCCACCAGCCGTACACCACTCAGGTCTACCTC       ATTGTCCACGTCCCTGCCCGCATTGTGAACATCTCGTCGCCTGTGACGGTGAATGAGGGGGGCAATGT       GAACCTGCTTTGCCTGGCCGTGGGGCGGCCAGAGCCCACGGTCACCTGGAGACAGCTCCGAGACGGCT       TCACCTCGGAGGGAGAGATCCTGGAGATCTCTGACATCCAGCGGGGCCAGGCCGGGGAGTATGAGTGC       GTGACTCACAACGGGGTTAACTCGGCGCCCGACAGCCGCCGCGTGCTGGTCACAGTCAACTATCCTCC       GACCATCACGGACGTGACCAGCGCCCGCACCGCGCTGGGCCGGGCCGCCCTCCTGCGCTGCGAAGCCA       TGGCGGTTCCCCCCGCGGATTTCCAGTGGTACAAGGATGACAGACTGCTGAGCAGCGGCACGGCCGAA       GGCCTGAAGGTGCAGACGGAGCGCACCCGCTCGATGCTTCTCTTTGCCAACGTGAGCGCCCGGCATTA       CGGCAACTATACGTGTCGCGCCGCCAACCGACTGGGAGCGTCCAGCGCCTCCATGCGGCTCCTGCGCC       CAGGATCCCTGGAGAACTCAGCCCCGAGGCCCCCAGGGCTCCTGGCCCTCCTCTCCGCCCTGGGCTGG       CTGTGGTGGAGAATGCTCGAGGGC                                         NOV11c, 278391050   SEQ ID NO: 286   325 aa   MW at 35781.1kD           Protein Sequence                     TKLLAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNRSNILYAGNDRWTSD           PRVRLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNV       NLLCLAVGRPEPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPP       TITDVTSARTALGRAALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHY       GNYTCRAANRLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRMLEG                                     NOV11d, 277582210   SEQ ID NO: 287   1760 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAAGCTTGGTGACAACGCCACCCTCAGCTGCTTCATCGACGAGCACGTGACCCGCGTGGCCTGGC           TGAACCGCTCCAACATCCTGTATGCCGGCAATGACCGCTGGACCAGCGACCCGCGGGTGCGGCTGCTC       ATCAACACCCCCGAGGAGTTCTCCATCCTCATCACCGAGGTGGGGCTCGGCGACGAGGGCCTCTACAC       CTGCTCCTTCCAGACCCGCCACCAGCCGTACACCACTCAGGTCTACCTCATTGTCCACGTCCCTGCCC       GCATTGTGAACATCTCGTCGCCTGTGACGGTGAATGAGGGGGGCAATGTGAACCTGCTTTGCCTGGCC       GTGGGGCGGCCAGAGCCCACGGTCACCTGGAGACAGCTCCGAGACGGCTTCACCTCGGAGGGAGAGAT       CCTGGAGATCTCTGACATCCAGCGGGGCCAGGCCGGGGAGTATGAGTGCGTGACTCACAACGGGGTTA       ACTCGGCGCCCGACAGCCGCCGCGTGCTGGTCACAGTCAACTATCCTCCGACCATCACGGACGTGACC       AGCGCCCGCACCGCGCTGGGCCGGGCCGCCCTCCTGCGCTGCGAAGCCATGGCGGTTCCCCCCGCGGA       TTTCCAGTGGTACAAGGATGACAGACTGCTGAGCAGCGGCACGGCCGAAGGCCTGAAGGTGCAGACGG       AGCGCACCCGCTCGATGCTTCTCTTTGCCAACGTGAGCGCCCGGCATTACGGCAACTATACGTGTCGC       GCCCTCGAGGGC                                         NOV11d, 277582210   SEQ ID NO: 288   253 aa   MW at 28074.3kD           Protein Sequence                     TKLGDNATLSCFIDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYT           CSFQTRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTSEGEI       LEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAALLRCEAMAVPPAD       FQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRALEG                                     NOV11e, 277582173   SEQ ID NO: 289   946 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAAGCTTCTGCTCTCCCAGAGCCTGGAGTTCAACTCTCCTGCCGACAACTACACAGTGTGTGAAG           GTGACAACGCCACCCTCAGCTGCTTCATCGACGAGCACGTGACCCGCGTGGCCTGGCTGAACCGCTCC       AACATCCTGTATGCCGGCAATGACCGCTGGACCAGCGACCCGCGGGTGCGGCTGCTCATCAACACCCC       CGAGGAGTTCTCCATCCTCATCACCGAGGTGGGGCTCGGCGACGAGGGCCTCTACACCTGCTCCTTCC       AGACCCGCCACCAGCCGTACACCACTCAGGTCTACCTCATTGTCCACGTCCCTGCCCGCATTGTGAAC       ATCTCGTCGCCTGTGACGGTGAATGAGGGGGGCAATGTGAACCTGCTTTGCCTGGCCGTGGGGCGGCC       AGAGCCCACGGTCACCTGGAGACAGCTCCGAGACGGCTTCACCTCGGAGGGAGAGATCCTGGAGATCT       CTGACATCCAGCGGGGCCAGGCCGGGGAGTATGAGTGCGTGACTCACAACGGGGTTAACTCGGCGCCC       GACAGCCGCCGCGTGCTGGTCACAGTCAACTATCCTCCGACCATCACGGACGTGACCAGCGCCCGCAC       CGCGCTGGGCCGGGCCGCCCTCCTGCGCTGCGAAGCCATGGCGGTTCCCCCCGCGGATTTCCAGTGGT       ACAAGGATGACAGACTGCTGAGCAGCGGCACGGCCGAAGGCCTGAAGGTGCAGACGGAGCGCACCCGC       TCGATGCTTCTCTTTGCCAACGTGAGCGCCCGGCATTACGGCAACTATACGTGTCGCGCCGCCAACCG       ACTGGGAGCGTCCAGCGCCTCCATGCGGCTCCTGCGCCCAGGATCCCTGGAGAACTCAGCCCCGAGGC       CCCCAGGGCTCCTGGCCCTCCTCTCCGCCCTGGGCTGGCTGTGGTGGAGAATGCTCGAGGGC                                         NOV11e, 277582173   SEQ ID NO: 290   315 aa   MW at 34843.0kD           Protein Sequence                     TKLLLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTP           EEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRP       EPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSART       ALGRAALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAANR       LGASSASMELLRPGSLENSAPRPPGLLALLSALGWLWWRMLEG                                     Nov11f, CG51027-09   SEQ ID NO: 291   976 bp           DNA Sequence   ORF Start: at 11   ORF Stop: at 968                       CACCAAGCTT CTGGCCGGCTTGGCCGTCATCAGCCGAGGGCTGCTCTCCCAGAGCCTGGAGTTCAACT           CTCCTGCCGACAACTACACAGTGTGTGAAGGTGACAACGCCACCCTCAGCTGCTTCATCGACGAGCAC       GTGACCCGCGTGGCCTGGCTGAACCGCTCCAACATCCTGTATGCCGGCAATGACCGCTGGACCAGCGA       CCCGCGGGTGCGGCTGCTCATCAACACCCCCGAGGAGTTCTCCATCCTCATCACCGAGGTGGGGCTCG       GCGACGAGGGCCTCTACACCTGCTCCTTCCAGACCCGCCACCAGCCGTACACCACTCAGGTCTACCTC       ATTGTCCACGTCCCTGCCCGCATTGTGAACATCTCGTCGCCTGTGACGGTGAATGAGGGGGGCAATGT       GAACCTGCTTTGCCTGGCCGTGGGGCGGCCAGAGCCCACGGTCACCTGGAGACAGCTCCGAGACGGCT       TCACCTCGGAGGGAGAGATCCTGGAGATCTCTGACATCCAGCGGGGCCAGGCCGGGGAGTATGAGTGC       GTGACTCACAACGGGGTTAACTCGGCGCCCGACAGCCGCCGCGTGCTGGTCACAGTCAACTATCCTCC       GACCATCACGGACGTGACCAGCGCCCGCACCGCGCTGGGCCGGGCCGCCCTCCTGCGCTGCGAAGCCA       TGGCGGTTCCCCCCGCGGATTTCCAGTGGTACAAGGATGACAGACTGCTGAGCAGCGGCACGGCCGAA       GGCCTGAAGGTGCAGACGGAGCGCACCCGCTCGATGCTTCTCTTTGCCAACGTGAGCGCCCGGCATTA       CGGCAACTATACGTGTCGCGCCGCCAACCGACTGGGAGCGTCCAGCGCCTCCATGCGGCTCCTGCGCC       CAGGATCCCTGGAGAACTCAGCCCCGAGGCCCCCAGGGCTCCTGGCCCTCCTCTCCGCCCTGGGCTGG       CTGTGGTGGAGAATGCTC GAGGGC                                           NOV11f, CG51027-09   SEQ ID NO: 292   319 aa   MW at 35139.3kD           Protein Sequence                     LAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCFIDENVTRVAWLNRSNILYAGNDRWTSDPRV           RLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLL       CLAVGRPEPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTIT       DVTSARTALGRAALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNY       TCRAANRLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRM                                     NOV11g, 316763704   SEQ ID NO: 293   976 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCTCGCGACTGGCCGGCTTGGCCGTCATCAGCCGAGGGCTGCTCTCCCAGAGCCTGGAGTTCAACT           CTCCTGCCGACAACTACACAGTGTGTGAAGGTGACAACGCCACCCTCAGCTGCTTCATCGACGAGCAC       GTGACCCGCGTGGCCTGGCTGAACCGCTCCAACATCCTGTATGCCGGCAATGACCGCTGGACCAGCGA       CCCGCGGGTGCGGCTGCTCATCAACACCCCCGAGGAGTTCTCCATCCTCATCACCGAGGTGGGGCTCG       GCGACGAGGGCCTCTACACCTGCTCCTTCCAGACCCGCCACCAGCCGTACACCACTCAGGTCTACCTC       ATTGTCCACGTCCCTGCCCGCATTGTGAACATCTCGTCGCCTGTGACGGTGAATGAGGGGGGCAATGT       GAACCTGCTTTGCCTGGCCGTGGGGCGGCCAGAGCCCACGGTCACCTGGAGACAGCTCCGAGACGGCT       TCACCTCGGAGGGAGAGATCCTGGAGATCTCTGACATCCAGCGGGGCCAGGCCGGGGAGTATGAGTGC       GTGACTCACAACGGGGTTAACTCGGCGCCCGACAGCCGCCGCGTGCTGGTCACAGTCAACTATCCTCC       GACCATCACGGACGTGACCAGCGCCCGCACCGCGCTGGGCCGGGCCGCCCTCCTGCGCTGCGAAGCCA       TGGCGGTTCCCCCCGCGGATTTCCAGTGGTACAAGGATGACAGACTGCTGAGCAGCGGCACGGCCGAA       GGCCTGAAGGTGCAGACGGAGCGCACCCGCTCGATGCTTCTCTTTGCCAACGTGAGCGCCCGGCATTA       CGGCAACTATACGTGTCGCGCCGCCAACCGACTGGGAGCGTCCAGCGCCTCCATGCGGCTCCTGCGCC       CAGGATCCCTGGAGAACTCAGCCCCGAGGCCCCCAGGGCTCCTGGCCCTCCTCTCCGCCCTGGGCTGG       CTGTGGTGGAGAATGGTCGACGGC                                         NOV11g, 316763704   SEQ ID NO: 294   325 aa   MW at 35755.0kD           Protein Sequence                     TSRLAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNRSNILYAGNDRWTSD           PRVRLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNV       NLLCLAVGRPEPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPP       TITDVTSARTALGRAALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFAINSARHY       GNYTCRAANRLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRMVDG                                     NOV11h, CG51027-01   SEQ ID NO: 295   1018 bp           DNA Sequence   ORF Start: at 1   ORF Stop: TAG at 958                     CTGGCCGGCTTGGCCGTCATCAGCCGAGGGCTGCTCTCCCAGAGCCTGGAGTTCAACTCTCCTGCCGA           CAACTACACAGTGTGTGAAGGTGACAACGCCACCCTCAGCTGCTTCATCGACGAGCACGTGACCCGCG       TGGCTTGGCTGAACCGCTCCAACATCCTGTATGCCGGCAATGACCGCTGGACCAGCGACCCGCGGGTG       CGGCTGCTCATCAACACCCCCGAGGAGTTCTCCATCCTCATCACCGAGGTGGGGCTCGGCGACGAGGG       CCTCTACACCTGCTCCTTCCAGACCCGCCACCAGCCGTACACCACTCAGGTCTACCTCATTGTCCACG       TCCCTGCCCGCATTGTGAACATCTCGTCGCCTGTGACGGTGAATGAGGGGGGCAATGTGAACCTGCTT       TGCCTGGCCGTGGGGCGGCCAGAGCCCACGGTCACCTGGAGACAGCTCCGAGACGGCTTCACCTCGGA       GGGAGAGATCCTGGAGATCTCTGACATCCAGCGGGGCCAGGCCGGGGAGTATGAGTGCGTGACTCACA       ACGGGGTTAACTCGGCGCCCGACAGCCGCCGCGTGCTGGTCACAGTCAACTATCCTCCGACCATCACG       GACGTGACCAGCGCCCGCACCGCGCTGGGCCGGACCGCCCTCCTGCGCTGCGAAGCCATGGCGGTTCC       CCCCGCGGATTTCCAGTGGTACAAGGATGACAGACTGCTGAGCAGCGGCACGGCCGAAGGCCTGAAGG       TGCAGACGGAGCGCACCCGCTCGATGCTTCTCTTTGCCAACGTGAGCGCCCGGCATTACGGCAACTAT       ACGTGTCGCGCCGCCAATCGACTGGGAGCGTCCAGCGCCTCCATGCGGCTCCTGCGCCCAGGATCCCT       GGAGAACTCAGCCCCGAGGCCCCCAGGGCTCCTGGCCCTCCTCTCCGCCCTGGGCTGGCTGTGGTGGA       GAATG TAG   GCGCAACCCAGTCCAGCTCACCTCCCCCTGCAGGGGGCCTCAAACCAAGAGTGAGAGA                                           NOV11h, CG51027-01   SEQ ID NO: 296   319 aa   MW at 35169.4kD           Protein Sequence                     LAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNRSNILYAGNDRWTSDPRV           RLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLL       CLAVGRPEPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTIT       DVTSARTALGRTALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNY       TCRAANRLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRM                                     NOV11i, CG51027-02   SEQ ID NO: 297   926 bp           DNA Sequence   ORF Start: at 1   ORF Stop: TAG at 922                     TCCCAGAGCCTGGAGTTCAACTCTCCTGCCGACAACTACACAGTGTGTGAAGGTGACAACGCCACCCT           CAGCTGCTTCATCGACGAGCACGTGACCCGCGTGGCCTGGCTGAACCGCTCCAACATCCTGTATGCCG       GCAATGACCGCTGGACCAGCGACCCGCGGGTGCGGCTGCTCATCAACACCCCCGAGGAGTTCTCCATC       CTCATCACCGAGGTGGGGCTCGGCGACGAGGGCCTCTACACCTGCTCCTTCCAGACCCGCCACCAGCC       GTACACCACTCAGGTCTACCTCATTGTCCACGTCCCTGCCCGCATTGTGAACATCTCGTCGCCTGTGA       CGGTGAATGAGGGGGGCAATGTGAACCTGCTTTGCCTGGCCGTGGGGCGGCCAGAGCCCACGGTCACC       TGGAGACAGCTCCGAGACGGCTTCACCTCGGAGGGAGAGATCCTGGAGATCTCTGACATCCAGCGGGG       CCAGGCCGGGGAGTATGAGTGCGTGACTCACAACGGGGTTAACTCGGCGCCCGACAGCCGCCGCGTGC       TGGTCACAGTCAACTATCCTCCGACCATCACGGACGTGACCAGCGCCCGCACCGCGCTGGGCCGGGCC       GCCCTCCTGCGCTGCGAAGCCATGGCGGTTCCCCCCGCGGATTTCCAGTGGTACAAGGATGACAGACT       GCTGAGCAGCGGCACGGCCGAAGGCCTGAAGGTGCAGACGGAGCGCACCCGCTCGATGCTTCTCTTTG       CCAACGTGAGCGCCCGGCATTACGGCAACTATACGTGTCGCGCCGCCAACCGACTGGGAGCGTCCAGC       GCCTCCATGCGGCTCCTGCGCCCAGGATCCCTGGAGAACTCAGCCCCGAGGCCCCCAGGGCTCCTGGC       CCTCCTCTCCGCCCTGGGCTGGCTGTGGTGGAGAATG TAG   GC                                           NOV11i, CG51027-02   SEQ ID NO: 298   307 aa   MW at 33974.9kD           Protein Sequence                     SQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSI           LITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVT       WRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRA       ALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAANRLGASS       ASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRM                                     NOV11j, CG51027-03   SEQ ID NO: 299   1171 bp           DNA Sequence   ORF Start: at 1   ORF Stop: TAG at 958                     CTGGCCGGCTTGGCCGTCATCAGCCGAGGGCTGCTCTCCCAGAGCCTGGAGTTCAACTCTCCTGCCGA           CAACTACACAGTGTGTGAAGGTGACAACGCCACCCTCAGCTGCTTCATCGACGAGCACGTGACCCGCG       TGGCCTGGCTGAACCGCTCCAACATCCTGTATGCCGGCAATGACCGCTGGACCAGCGACCCGCGGGTG       TGGCTGCTCATCAACACCCCCGAGGAGTTCTCCATCCTCATCACCGAGGTGGGGCTCGGCGACGAGGG       CCTCTACACCTGCTCCTTCCAGACCCGCCACCAGCCGTACACCACTCAGGTCTACCTCATTGTCCACG       TCCCTGCCCGCATTGTGAACATCTCGTCGCCTGTGATGGTGAATGAGGGGGGCAATGTGAACCTGCTT       TGCCTGGCCGTGGGGCGGCCAGAGCCCACGGTCACCTGGAGACAGCTCCGAGACGGCTTCACCTCGGA       GGGAGAGATCCTGGAGATCTCTGACATCCAGCGGGGCCAGGCCGGGGAGTATGAGTGCGTGACTCACA       ACGGGGTTAACTCGGCGCCCGACAGCCGCCGCGTGCTGGTCACAGTCAACTATCCTCCGACCATCACG       GACGTGACCAGCGCCCGCACCGCGCTGGGCCGGGCCGCCCTCCTGCGCTGCGAAGCCATGGCGGTTCC       CCCCGCGGATTTCCAGTGGTATAAGGATGACAGACTGCTGAGCAGCGGCACGGCCGAAGGCCTGAAGG       TGCAGATGGAGCGCACCCGCTCGATGCTTCTCTTTGCCAACGTGAGCGCCCGGCATTACGGCAACTAT       ACGTGTCGCGCCGCCAACCGACTGGGAGCGTCCAGCGCCTCCATGCGGCTCCTGCGCCCAGGATCCCT       GGAGAACTCAGCCCCGAGGCCCCCAGGGCTCCTGGCCCTCCTCTCCGCCCTGGGCTGGCTGTGGTGGA       GAATG TAG   GCGCAACCCAGTGGAGCTCACCTCCCCCTGCAGGGGGCCTCAGGCCAAGAGTGAGAGAAA           CGGGGGAGCAAGAGCCGTGGGTCTCGTGGGGGCAGAAGAGCTCTCGGCCACCAAGGAAGAAGAGAGAG           GAGAAGAGGAGGAGGCAGAGGAAGAAAGATCTTCAGAGAACCCATCACTGTGAGGGATAACGCAAAAT           TATGCATCTTTCTAC                                           NOV11j, CG51027-03   SEQ ID NO: 300   319 aa   MW at 35229.6kD           Protein Sequence                     LAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNRSNILYAGNDRWTSDPRV           WLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIVNISSPVMVNEGGNVNLL       CLAVGRPEPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTIT       DVTSARTALGRAALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQMERTRSMLLFANVSARHYGNY       TCRAACRLGASSASMRLLRPGSLENSAPRPPGLLALLSALSWLWWRM                                     NOV11k, CG51027-04   SEQ ID NO: 301   927 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     TTGGCCGTCATCAGCCGAGGGCTGCTCTCCCAGAGCCTGGAGTTCAACTCTCCTGCCGACAACTACAC           AGTGTGTGAAGGTGACAACGCCACCCTCAGCTGCTTCATCGACGAGCACGTGACCCGCGTGGCCTGGC       TGAACCGCTCCAACATCCTGTATGCCGGCAATGACCGCTGGACCAGCGACCCGCGGGTGCGGCTGCTC       ATCAACACCCCCGAGGAGTTCTCCATCCTCATCACCGAGGTGGGGCTCGGCGACGAGGGCCTCTACAC       CTGCTCCTTCCAGACCCGCCACCAGCCGTACACCACTCAGGTCTACCTCATTGTCCACGTCCCTGCCC       GCATTGTGAACATCTCGTCGCCTGTGACGGTGAATGAGGGGGGCAATGTGAACCTGCTTTGCCTGGCC       GTGGGGCGGCCAGAGCCCACGGTCACCTGGAGACAGCTCCGAGACGGCTTCACCTCGGAGGGAGAGAT       CCTGGAGATCTCTGACATCCAGCGGGGCCAGGCCGGGGAGTATGAGTGCGTGACTCACAACGGGGTTA       ACTCGGCGCCCGACAGCCGCCGCGTGCTGGTCACAGTCAACTATCCTCCGACCATCACGGACGTGACC       AGCGCCCGCACCGCGCTGGGCCGGGCCGCCCTCCTGCGCTGCGAAGCCATGGCGGTTCCCCCCGCGGA       TTTCCAGTGGTACAAGGATGACAGACTGCTGAGCAGCGGCACGGCCGAAGGCCTGAAGGTGCAGACGG       AGCGCACCCGCTCGATGCTTCTCTTTGCCAACGTGAGCGCCCGGCATTACGGCAACTATACGTGTCGC       GCCGCCAACCGACTGGGAGCGTCCAGCGCCTCCATGCGGCTCCTGCGCCCAGGATCCCTGGAGAACTC       AGCCCCGAGGCCCCCAGGGCTCCTGGCCCTCCTCTCCGCCCTG                                         NOV11k, CG51 027-04   SEQ ID NO: 302   309 aa   MW at 33881.8kD           Protein Sequence                     LAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLL           INTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLA       VGRPEPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVT       SARTALGRAALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCR       AANRLGASSASMRLLRPGSLENSAPRPPGLLALLSAL                                     NOV11l, CG51027-05   SEQ ID NO: 303   1169 bp           DNA Sequence   ORF Start: ATG at 71   ORF Stop: TAG at 1079                       CTCCAACAAGCATAGCGCGCCCCGGACCGGCCCCCCCTTTCCCCTCCCCCTCCGTGCCGCCTCTGCCG               CG   ATG CCCCCCGCTGCGCCCGGGGCCCGGCTCCGGCTTCTCGCCGCCGCCGCCCTGGCCGGCTTGGCC       GTCATCAGCCGGGGGCTGCTCTCCCAGAGGCTGGAGTTCAACTCTCCTGCCGACAACTACACAGTGTG       TGAAGGTGACAACGCCACCCTCAGCTGCTTCATGGACGAGCATGTGACCCGCGTGGCCTGGCTGAACC       GCTCCAACATCCTGTACGCCGGCAACGACCGCAGGACCAGGGACCCGCGGGTGCGGCTGCTCATCAAC       ACCCCCGAGGAGTTCTCCATCCTCGTCACCGAGGTGGGGCTCGGCGACGAGGGCCTCTACACCTGCTC       CTTCCAGACCCGCCACCAGCCGTACACCACTCAGGTCTACCTCATTGTCCACGTCCCTGCCCGCGTTG       TGAACATCTCGTCGCCTGTGATGGTGAATGAGGGAGGTAATGTGAACCTGCTTTGCCTGGCCGTGGGG       CGGCCAGAGCCCACGGTCACCTGGAGACAGCTCCGAGACGGCTTCACCTCGGAGGGAGAGATCCTGGA       GATCTCTGACATCCTGCGGGGCCAGGCCGGGGAGTATGAGTGCGTGACTCACAACGGGGTTAACTCGG       CGCCCGACAGCCGCCGCGTGCTGGTCACAGTCAACTATCCTCCGACCATCACGGACGT9ACCAGCGCC       CGCACCGCGCTGGGGCCGGGCCGCCTACTGCGCTGCGAAGCCATGGCGGTTTCCCCCGCGGATTTCCA       GTGGTATAAGGATGACAGACTACTGAGCAGCGGCACGGCCGAGGGCCTGAAGGTGCAGATGGAGCGCA       CTCGCTCGATGCTTCTCTTTGCCAACATGAGCGCCCGGCATTACGGCAACTATACGTGTTGCGCCGCC       AACCGGCTGGGAGCGTCCAGCGCCTCCATGCGGCTCCTGTGCCCAGGATCCCTGGAGAACTCAGCCCC       GAGGCCCCCAGGGCCCCTGGCCCTCCTCTCCGCCCTGGGCTGGCTGTGGTGGAGAATG TAG   GCGCAAC           CCAGTGGAGCTCGCCTCCCCCTGCAGGGGGCCTCAGGCCAAGAGTGAGAGAAAAGGGGGAGCAAGAGC           CCTGGGTCTCGTG                                           NOV11l, CG51027-05   SEQ ID NO: 304   336 aa   MW at 36823.6kD           Protein Sequence                     MPPAAPGARLRLLAAAALAGLAVISRGLLSQRLEFNSPADNYTVCEGDNATLSCFMDEHVTRVAWLNR           SNILYAGNDRRTRDPRVRLLINTPEEFSILVTEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARVV       NISSPVMVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTSEGEILEISDILRGQAGEYECVTHNGVNSA       PDSRRVLVTVNYPPTITDVTSARTALGPGRLLRCEAMAVSPADFQWYKDDRLLSSGTAEGLKVQMERT       RSMLLFANMSARHYGNYTCCAANRLGAS SASMRLLCPGSLENSAPRPPGPLALLSALGWLWWRM                                     NOV11m, CG51027-07   SEQ ID NO: 305   946 bp           DNA Sequence   ORF Start: at 11   ORF Stop: at 938                       CACCAAGCTT CTGCTCTCCCAGAGCCTGGAGTTCAACTCTCCTGCCGACAACTACACAGTGTGTGAAG           GTGACAACGCCACCCTCAGCTGCTTCATCGACGAGCACGTGACCCGCGTGGCCTGGCTGAACCGCTCC       AACATCCTGTATGCCGGCAATGACCGCTGGACCAGCGACCCGCGGGTGCGGCTGCTCATCAACACCCC       CGAGGAGTTCTCCATCCTCATCACCGAGGTGGGGCTCGGCGACGAGGGCCTCTACACCTGCTCCTTCC       AGACCCGCCACCAGCCGTACACCACTCAGGTCTACCTCATTGTCCACGTCCCTGCCCGCATTGTGAAC       ATCTCGTCGCCTGTGACGGTGAATGAGGGGGGCAATGTGAACCTGCTTTGCCTGGCCGTGGGGCGGCC       AGAGCCCACGGTCACCTGGAGACAGCTCCGAGACGGCTTCACCTCGGAGGGAGAGATCCTGGAGATCT       CTGACATCCAGCGGGGCCAGGCCGGGGAGTATGAGTGCGTGACTCACAACGGGGTTAACTCGGCGCCC       GACAGCCGCCGCGTGCTGGTCACAGTCAACTATCCTCCGACCATCACGGACGTGACCAGCGCCCGCAC       CGCGCTGGGCCGGGCCGCCCTCCTGCGCTGCGAAGCCATGGCGGTTCCCCCCGCGGATTTCCAGTGGT       ACAAGGATGACAGACTGCTGAGCAGCGGCACGGCCGAAGGCCTGAAGGTGCAGACGGAGCGCACCCGC       TCGATGCTTCTCTTTGCCAACGTGAGCGCCCGGCATTACGGCAACTATACGTGTCGCGCCGCCAACCG       ACTGGGAGCGTCCAGCGCCTCCATGCGGCTCCTGCGCCCAGGATCCCTGGAGAACTCAGCCCCGAGGC       CCCCAGGGCTCCTGGCCCTCCTCTCCGCCCTGGGCTGGCTGTGGTGGAGAATGCTC GAGGGC                                           NOV11m, CG51027-07   SEQ ID NO: 306   309 aa   MW at 34201.2kD           Protein Sequence                     LLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNRSMILYAGNDRWTSDPRVRLLINTPEEF           SILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPT       VTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALG       RAALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAANRLGA       SSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRM                                     NOV11n, CG51027-08   SEQ ID NO: 307   1033 bp           DNA Sequence   ORF Start: ATG at 17   ORF Stop: at 1025                       CACCAAGCTTCCCACC   ATG CCCCCCCCTGCGCCCGGGGCCCGGCTCCGGCTTCTCGCCGCCGCCGCCC           TGGCCGGCTTGGCCGTCATCAGCCGAGGGCTGCTCTCCCAGAGCCTGGAGTTCAACTCTCCTGCCGAC       AACTACACAGTGTGTGAAGGTGACAACGCCACCCTCAGCTGCTTCATCGACGAGCACGTGACCCGCGT       GGCCTGGCTGAACCGCTCCAACATCCTGTATGCCGGCAATGACCGCTGGACCAGCGACCCGCGGGTGC       GGCTGCTCATCAACACCCCCGAGGAGTTCTCCATCCTCATCACCGAGGTGGGGCTCGGCGACGAGGGC       CTCTACACCTGCTCCTTCCAGACCCGCCACCAGCCGTACACCACTCAGGTCTACCTCATTGTCCACGT       CCCTGCCCGCATTGTGAACATCTCGTCGCCTGTGACGGTGAATGAGGGGGGCAATGTGAACCTGCTTT       GCCTGGCCGTGGGGCGGCCAGAGCCCACGGTCACCTGGAGACAGCTCCGAGACGGCTTCACCTCGGAG       GGAGAGATCCTGGAGATCTCTGACATCCAGCGGGGCCAGGCCGGGGAGTATGAGTGCGTGACTCACAA       CGGGGTTAACTCGGCGCCCGACAGCCGCCGCGTGCTGGTCACAGTCAACTATCCTCCGACCATCACGG       ACGTGACCAGCGCCCGCACCGCGCTGGGCCGGGCCGCCCTCCTGCGCTGCGAAGCCATGGCGGTTCCC       CCCGCGGATTTCCAGTGGTACAAGGATGACAGACTGCTGAGCAGCGGCACGGCCGAAGGCCTGAAGGT       GCAGACGGAGCGCACCCGCTCGATGCTTCTCTTTGCCAACGTGAGCGCCCGGCATTACGGCAACTATA       CGTGTCGCGCCGCCAACCGACTGGGAGCGTCCAGCGCCTCCATGCGGCTCCTGCGCCCAGGATCCCTG       GAGAACTCAGCCCCGAGGCCCCCAGGGCTCCTGGCCCTCCTCTCCGCCCTGGGCTGGCTGTGGTGGAG       AATGCTC GAGGGC                                           NOV11n, CG51027-08   SEQ ID NO: 308   336 aa   MW at 36794.3kD           Protein Sequence                     MPPPAPGARLRLLAAAALAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNR           SNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIV       NISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSA       PDSRRVLVTVNYPPTITDVTSARTALGRAALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERT       RSMLLFANVSARHYGNYTCRAANPLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWPM                                     NOV11o, CG51027-10   SEQ ID NO: 309   1035 bp           DNA Sequence   ORF Start: ATG at 16   ORF Stop: TAG at 1024                       CACCGCGGCCGCACC   ATG CCCCCCCCTGCGCCCGGGGCCCGGCTCCGGCTTCTCGCCGCCGCCGCCCT           GGCCGGCTTGGCCGTCATCAGCCGAGGGCTGCTCTCCCAGAGCCTGGAGTTCAACTCTCCTGCCGACA       ACTACACAGTGTGTGAAGGTGACAACGCCACCCTCAGCTGCTTCATCGACGAGCACGTGACCCGCGTG       GCCTGGCTGAACCGCTCCAACATCCTGTATGCCGGCAATGACCGCTGGACCAGCGACCCGCGGGTGCG       GCTGCTCATCAACACCCCCGAGGAGTTCTCCATCCTCATCACCGAGGTGGGGCTCGGCGACGAGGGCC       TCTACACCTGCTCCTTCCAGACCCGCCACCAGCCGTACACCACTCAGGTCTACCTCATTGTCCACGTC       CCTGCCCGCATTGTGAACATCTCGTCGCCTGTGACGGTGAATGAGGGGGGCAATGTGAACCTGCTTTG       CCTGGCCGTGGGGCGGCCAGAGCCCACGGTCACCTGGAGACAGCTCCGAGACGGCTTCACCTCGGAGG       GAGAGATCCTGGAGATCTCTGACATCCAGCGGGGCCAGGCCGGGGAGTATGAGTGCGTGACTCACAAC       GGGGTTAACTCGGCGCCCGACAGCCGCCGCGTGCTGGTCACAGTCAACTATCCTCCGACCATCACGGA       CGTGACCAGCGCCCGCACCGCGCTGGGCCGGGCCGCCCTCCTGCGCTGCGAAGCCATGGCGGTTCCCC       CCGCGGATTTCCAGTGGTACAAGGATGACAGACTGCTGAGCAGCGGCACGGCCGAAGGCCTGAAGGTG       CAGACGGAGCGCACCCGCTCGATGCTTCTCTTTGCCAACGTGAGCGCCCGGCATTACGGCAACTATAC       GTGTCGCGCCGCCAACCGACTGGGAGCGTCCAGCGCCTCCATGCGGCTCCTGCGCCCAGGATCCCTGG       AGAACTCAGCCCCGAGGCCCCCAGGGCTCCTGGCCCTCCTCTCCGCCCTGGGCTGGCTGTGGTGGAGA       ATG TAG   GTCGACGGC                                           NOV11o, CG51027-10   SEQ ID NO: 310   336 aa   MW at 36794.3kD           Protein Sequence                     MPPPAPGARLRLLAAAALAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNR           SNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIV       NISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSA       PDSRRVLVTVNYPPTITDVTSARTALGRAALLRCEAMAVPPALFQWYKDDRLLSSGTAEGLKVQTERT       RSMLLFANVSARHYGNYTCRAANRLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRM                                     NOV11p, CG51027-11   SEQ ID NO: 311   976 bp           DNA Sequence   ORF Start: at 11   ORF Stop: at 971                       CACCTCGCGA CTGGCCGGCTTGGCCGTCATCAGCCGAGGGCTGCTCTCCCAGAGCCTGGAGTTCAACT           CTCCTGCCGACAACTACACAGTGTGTGAAGGTGACAACGCCACCCTCAGCTGCTTCATCGACGAGCAC       GTGACCCGCGTGGCCTGGCTGAACCGCTCCAACATCCTGTATGCCGGCAATGACCGCTGGACCAGCGA       CCCGCGGGTGCGGCTGCTCATCAACACCCCCGAGGAGTTCTCCATCCTCATCACCGAGGTGGGGCTCG       GCGACGAGGGCCTCTACACCTGCTCCTTCCAGACCCGCCACCAGCCGTACACCACTCAGGTCTACCTC       ATTGTCCACGTCCCTGCCCGCATTGTGAACATCTCGTCGCCTGTGACGGTGAATGAGGGGGGCAATGT       GAACCTGCTTTGCCTGGCCGTGGGGCGGCCAGAGCCCACGGTCACCTGGAGACAGCTCCGAGACGGCT       TCACCTCGGAGGGAGAGATCCTGGAGATCTCTGACATCCAGCGGGGCCAGGCCGGGGAGTATGAGTGC       GTGACTCACAACGGGGTTAACTCGGCGCCCGACAGCCGCCGCGTGCTGGTCACAGTCAACTATCCTCC       GACCATCACGGACGTGACCAGCGCCCGCACCGCGCTGGGCCGGGCCGCCCTCCTGCGCTGCGAAGCCA       TGGCGGTTCCCCCCGCGGATTTCCAGTGGTACAAGGATGACAGACTGCTGAGCAGCGGCACGGCCGAA       GGCCTGAAGGTGCAGACGGAGCGCACCCGCTCGATGCTTCTCTTTGCCAACGTGAGCGCCCGGCATTA       CGGCAACTATACGTGTCGCGCCGCCAACCGACTGGGAGCGTCCAGCGCCTCCATGCGGCTCCTGCGCC       CAGGATCCCTGGAGAACTCAGCCCCGAGGCCCCCAGGGCTCCTGGCCCTCCTCTCCGCCCTGGGCTGG       CTGTGGTGGAGAATGGTCGAC GGC                                           NOV11p, CG51027-11   SEQ ID NO: 312   320 aa   MW at 35238.5kD           Protein Sequence                     LAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNRSNILYAGNDRWTSDPRV           RLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLL       CLAVGRPEPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTIT       DVTSARTALGRAALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNY       TCRAANRLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRMV                                     NOV11q, CG51027-12   SEQ ID NO: 313   1030 bp           DNA Sequence   ORF Start: ATG at 14   ORF Stop: at 1022                       CACCTCGCGAACC   ATG CCCCCCCCTGCGCCCGGGGCCCGGCTCCGGCTTCTCGCCGCCGCCGCCCTGG           CCGGCTTGGCCGTCATCAGCCGAGGGCTGCTCTCCCAGAGCCTGGAGTTCAACTCTCCTGCCGACAAC       TACACAGTGTGTGAAGGTGACAACGCCACCCTCAGCTGCTTCATCGACGAGCACGTGACCCGCGTGGC       CTGGCTGAACCGCTCCAACATCCTGTATGCCGGCAATGACCGCTGGACCAGCGACCCGCGGGTGCGGC       TGCTCATCAACACCCCCGAGGAGTTCTCCATCCTCATCACCGAGGTGGGGCTCGGCGACGAGGGCCTC       TACACCTGCTCCTTCCAGACCCGCCACCAGCCGTACACCACTCAGGTCTACCTCATTGTCCACGTCCC       TGCCCGCATTGTGAACATCTCGTCGCCTGTGACGGTGAATGAGGGGGGCAATGTGAACCTGCTTTGCC       TGGCCGTGGGGCGGCCAGAGCCCACGGTCACCTGGAGACAGCTCCGAGACGGCTTCACCTCGGAGGGA       GAGATCCTGGAGATCTCTGACATCCAGCGGGGCCAGGCCGGGGAGTATGAGTGCGTGACTCACAACGG       GGTTAACTCGGCGCCCGACAGCCGCCGCGTGCTGGTCACAGTCAACTATCCTCCGACCATCACGGACG       TGACCAGCGCCCGCACCGCGCTGGGCCGGGCCGCCCTCCTGCGCTGCGAAGCCATGGCGGTTCCCCCC       GCGGATTTCCAGTGGTACAAGGATGACAGACTGCTGAGCAGCGGCACGGCCGAAGGCCTGAAGGTGCA       GACGGAGCGCACCCGCTCGATGCTTCTCTTTGCCAACGTGAGCGCCCGGCATTACGGCAACTATACGT       GTCGCGCCGCCAACCGACTGGGAGCGTCCAGCGCCTCCATGCGGCTCCTGCGCCCAGGATCCCTGGAG       AACTCAGCCCCGAGGCCCCCAGGGCTCCTGGCCCTCCTCTCCGCCCTGGGCTGGCTGTGGTGGAGAAT       GGTC GACGGC                                           NOV11q, CG51027-12   SEQ ID NO: 314   336 aa   MW at 36794.3kD           Protein Sequence                     MPPPAPGARLRLLAAAALAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNR           SNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIV       NISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSA       PDSRRVLVTVNYPPTITDVTSARTALGRAALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERT       RSMLLFANVSARHYGNYTCRAANRLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRM                                     NOV11r, SNP13376340   SEQ ID NO: 315   1271 bp           of CG51027-06,   ORF Start: ATG at 48   ORF Stop: TAG at 1056       DNA Sequence   SNP Pos: 888   SNP Change: G to A                       GCGCAGTGTGCTGGAATTCGCCCTTCCTCCGTGCCGCCTCTGCCGCG   ATG CCCCCCCCTGCGCCCGGG           GCCCGGCTCCGGCTTCTCGCCGCCGCCGCCCTGGCCGGCTTGGCCGTCATCAGCCGAGGGCTGCTCTC       CCAGAGCCTGGAGTTCAACTCTCCTGCCGACAACTACACAGTGTGTGAAGGTGACAACGCCACCCTCA       GCTGCTTCATCGACGAGCACGTGACCCGCGTGGCCTGGCTGAACCGCTCCAACATCCTGTATGCCGGC       AATGACCGCTGGACCAGCGACCCGCGGGTGCGGCTGCTCATCAACACCCCCGAGGAGTTCTCCATCCT       CATCACCGAGGTGGGGCTCGGCGACGAGGGCCTCTACACCTGCTCCTTCCAGACCCGCCACCAGCCGT       ACACCACTCAGGTCTACCTCATTGTCCACGTCCCTGCCCGCATTGTGAACATCTCGTCGCCTGTGATG       GTGAATGAGGGGGGCAATGTGAACCTGCTTTGCCTGGCCGTGGGGCGGCCAGAGCCCACGGTCACCTG       GAGACAGCTCCGAGACGGCTTCACCTCGGAGGGAGAGATCCTGGAGATCTCTGACATCCAGCGGGGCC       AGGCCGGGGAGTATGAGTGCGTGACTCACAACGGGGTTAACTCGGCGCCCGACAGCCGCCGCGTGCTG       GTCACAGTCAACTATCCTCCGACCATCACGGACGTGACCAGCGCCCGCACCGCGCTGGGCCGGGCCGC       CCTCCTGCGCTGCGAAGCCATGGCGGTTCCCCCCGCGGATTTCCAGTGGTATAAGGATGACAGACTGC       TGAGCAGCGGCACGGCCGAAGGCCTGAAGGTGCAGATGGAGCGCACCCGCTCGATGCTTCTCTTTGCC       AAC   A   TGAGCGCCCGGCATTACGGCAACTATACGTGTTGCGCCGCCAACCGACTGGGAGCGTCCAGCGC       CTCCATGCGGCTCCTGTGCCCAGGATCCCTGGAGAACTCAGCCCCGAGGCCCCCAGGGCTCCTGGCCC       TCCTCTCCGCCCTGGGCTGGCTGTGGTGGAGAATG TAG   GCGCAACCCAGTGGAGCTCGCCTCCCCCTG           CAGGGGGCCTCAGGCCAAGAGTGAGAGAAAAGGGGGAGCAAGAGCCCTGGGTCTCGTGGGGGCAGAAG           GGCTCTCGGCCACCAAGGAAGAAGAGAAGAGGAGAAAGAGGAGGAGGCAGAGGAAGAAAGATCTTTAG           AGAACCCATCACTGTGAGGGATAACGCAAAATTATGCATCTTTCTAC                                           NOV11r, SNP13376340   SEQ ID NO: 316   336 aa   MW at 36780.5kD           of CG51027-06,   SNP Pos: 281       SNP Change:       Protein Sequence           Val to Met                     MPPPAPGARLRLLAAAALAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNR           SNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARTV       NISSPVMVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSA       PDSRRVLVTVNYPPTITDVTSARTALGRAALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQMERT       RSMLLFAN   M   SARHYGNYTCCAANPLGASSASMRLLCPGSLENSAPRPPGLLALLSALGWLWWRM                                     NOV11s, SNP13376341   SEQ ID NO: 317   1271 bp           of CG51027-06,   ORF Start: ATG at 48   ORF Stop: TAG at 1056       DNA Sequence   SNP Pos: 941   SNP Change: A to G                       GCGCAGTGTGCTGGAATTCGCCCTTCCTCCGTGCCGCCTCTGCCGCG   ATG CCCCCCCCTGCGCCCGGG           GCCCGGCTCCGGCTTCTCGCCGCCGCCGCCCTGGCCGGCTTGGCCGTCATCAGCCGAGGGCTGCTCTC       CCAGAGCCTGGAGTTCAACTCTCCTGCCGACAACTACACAGTGTGTGAAGGTGACAACGCCACCCTCA       GCTGCTTCATCGACGAGCACGTGACCCGCGTGGCCTGGCTGAACCGCTCCAACATCCTGTATGCCGGC       AATGACCGCTGGACCAGCGACCCGCGGGTGCGGCTGCTCATCAACACCCCCGAGGAGTTCTCCATCCT       CATCACCGAGGTGGGGCTCGGCGACGAGGGCCTCTACACCTGCTCCTTCCAGACCCGCCACCAGCCGT       ACACCACTCAGGTCTACCTCATTGTCCACGTCCCTGCCCGCATTGTGAACATCTCGTCGCCTGTGATG       GTGAATGAGGGGGGCAATGTGAACCTGCTTTGCCTGGCCGTGGGGCGGCCAGAGCCCACGGTCACCTG       GAGACAGCTCCGAGACGGCTTCACCTCGGAGGGAGAGATCCTGGAGATCTCTGACATCCAGCGGGGCC       AGGCCGGGGAGTATGAGTGCGTGACTCACAACGGGGTTAACTCGGCGCCCGACAGCCGCCGCGTGCTG       GTCACAGTCAACTATCCTCCGACCATCACGGACGTGACCAGCGCCCGCACCGCGCTGGGCCGGGCCGC       CCTCCTGCGCTGCGAAGCCATGGCGGTTCCCCCCGCGGATTTCCAGTGGTATAAGGATGACAGACTGC       TGAGCAGCGGCACGGCCGAAGGCCTGAAGGTGCAGATGGAGCGCACCCGCTCGATGCTTCTCTTTGCC       AACGTGAGCGCCCGGCATTACGGCAACTATACGTGTTGCGCCGCCAACCGACTGGG   G   GCGTCCAGCGC       CTCCATGCGGCTCCTGTGCCCAGGATCCCTGGAGAACTCAGCCCCGAGGCCCCCAGGGCTCCTGGCCC       TCCTCTCCGCCCTGGGCTGGCTGTGGTGGAGAATG TAG   GCGCAACCCAGTGGAGCTCGCCTCCCCCTG           CAGGGGGCCTCAGGCCAAGAGTGAGAGAAAAGGGGGAGCAAGAGCCCTGGGTCTCGTGGGGGCAGAAG           GGCTCTCGGCCACCAAGGAAGAAGAGAAGAGGAGAAAGAGGAGGAGGCAGAGGAAGAAAGATCTTTAG           AGAACCCATCACTGTGAGGGATAACGCAAAATTATGCATCTTTCTAC                                           NOV11s, SNP13376341   SEQ ID NO: 318   336 aa   MW at 36748.4kD           of CG51027-06,   SNP Pos: 298       SNP Change:       Protein Sequence           Gly to Gly                     MPPPAPGARLRLLAAAALAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCFIDEHVTRVAWLNR           SNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIV       NISSPVMVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSA       PDSRRVLVTVNYPPTITDVTSARTALGRAALLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQMERT       RSMLLFAIVSARHYGNYTCCAANPLGASSASMRLLCPGSLENSAPRPPGLEALLSALGWLWWRM                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 11B.  
               TABLE 11B                       Comparison of the NOV11 protein sequences.                                        NOV11a -----MPPPAPGARLRLLAAAALAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCF           NOV11b TKLPTMPPPAPGARLRLLAAAALAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCF       NOV11c -------------------TKLLAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCF       NOV11d ------------------------------------------------TKLGDNATLSCF       NOV11e -----------------------------TKLLLSQSLEFNSPADNYTVCEGDNATLSCF       NOV11f ----------------------LAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCF       NOV11g -------------------TSRLAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCF       NOV11h ----------------------LAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCF       NOV11i ----------------------------------SQSLEFNSPADNYTVCEGDNATLSCF       NOV11j ----------------------LAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCF       NOV11k -------------------------LAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCF       NOV11l -----MPPAAPGARLRLLAAAALAGLAVISRGLLSQRLEFNSPADNYTVCEGDNATLSCF       NOV11m --------------------------------LLSQSLEFNSPADNYTVCEGDNATLSCF       NOV11n -----MPPPAPGARLRLLAAAALAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCF       NOV11o -----MPPPAPGARLRLLAAAALAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCF       NOV11p ----------------------LAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCF       NOV11q -----MPPPAPGARLRLLAAAALAGLAVISRGLLSQSLEFNSPADNYTVCEGDNATLSCF               NOV11a IDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQ       NOV11b IDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQ       NOV11c IDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQ       NOV11d IDEHVTRVAWLNRSNTLYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQ       NOV11e IDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQ       NOV11f IDEHVTRVAWLNRSNTLYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQ       NOV11g IDEBVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQ       NOV11h IDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQ       NOV11i IDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQ       NOV11j IDEHVTRVAWLNRSNILYAGNDRWTSDPRVWLLINTPEEFSILITEVGLGDEGLYTCSFQ       NOV11k IDENVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQ       NOV11l MDEHVTRVAWLNRSNILYAGNDRRTRDPRVRLLINTPEEFSILVTEVGLGDEGLYTCSFQ       NOV11m IDENVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQ       NOV11n IDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQ       NOV11o IDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQ       NOV11p IDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQ       NOV11q IDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQ               NOV11a TRHQPYTTQVYLIVHVPARIVNISSPVMVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS       NOV11b TRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS       NOV11c TRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS       NOV11d TRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS       NOV11e TRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS       NOV11f TRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS       NOV11g TRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS       NOV11h TRHQPYTTQVYLIVHVPARIVNISSPVRTNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS       NOV11i TRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS       NOV11j TRHQPYTTQVYLIVHVPARIVNISSPVMVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS       NOV11k TRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS       NOV11l TRHQPYTTQVYLIVHVPARVVNISSPVMVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS       NOV11m TRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS       NOV11n TRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCIAVGRPEPTVTWRQLRDGFTS       NOV11o TRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS       NOV11p TRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS       NOV11q TRHQPYTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTS               NOV11a EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL       NOV11b EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL       NOV11c EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL       NOV11d EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL       NOV11e EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL       NOV11f EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL       NOV11g EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL       NOV11h EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRTAL       NOV11i EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL       NOV11j EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL       NOV11k EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL       NOV11l EGEILEISDILRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGPGRL       NOV11m EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL       NOV11n EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL       NOV11o EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL       NOV11p EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL       NOV11q EGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL               NOV11a LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQMERTRSMLLFANVSARHYGNYTCCAAN       NOV11b LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAAN       NOV11c LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAAN       NOV11d LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRALE       NOV11e LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAAN       NOV11f LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAAN       NOV11g LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAAN       NOV11h LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAAN       NOV11i LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAAN       NOV11j LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQMERTRSMLLFANVSARHYGNYTCRAAN       NOV11k LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAAN       NOV11l LRCEAMAVSPADFQWYKDDRLLSSGTAEGLKVQMERTRSMLLFANMSARHYGNYTCCAAN       NOV11m LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAAN       NOV11n LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCPAAN       NOV11o LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAAN       NOV11p LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAAN       NOV11q LRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAAN               NOV11a RLGASSASMRLLCPGSLENSAPRPPGLLALLSALGWLWWRM---       NOV11b RLGASSASMPLLRPGSLENSAPRPPGLLALLSALGWLWWRMLEG       NOV11c RLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRMLEG       NOV11d G-------------------------------------------       NOV11e RLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRMLEG       NOV11f RLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWPM---       NOV11g RLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRMVDG       NOV11h RLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRM---       NOV11i RLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRM---       NOV11j RLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRM---       NOV11k RLGASSASMRLLRPGSLENSAPRPPGLLALLSAL----------       NOV11l RLGASSASMRLLCPGSLENSAPRPPGPLALLSALGWLWWRM---       NOV11m RLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRM---       NOV11n RLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRM---       NOV11o RLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRM---       NOV11p RLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWPMV--       NOV11q RLGASSASMRLLRPGSLENSAPRPPGLLALLSALGWLWWRM---               NOV11a (SEQ ID NO: 282)       NOV11b (SEQ ID NO: 284)       NOV11c (SEQ ID NO: 286)       NOV11d (SEQ ID NO: 288)       NOV11e (SEQ ID NO: 290)       NOV11f (SEQ ID NO: 292)       NOV11g (SEQ ID NO: 294)       NOV11h (SEQ ID NO: 296)       NOV11i (SEQ ID NO: 298)       NOV11j (SEQ ID NO: 300)       NOV11k (SEQ ID NO: 302)       NOV11l (SEQ ID NO: 304)       NOV11m (SEQ ID NO: 306)       NOV11n (SEQ ID NO: 308)       NOV11o (SEQ ID NO: 310)       NOV11p (SEQ ID NO: 312)       NOV11q (SEQ ID NO: 314)                  
 
      Further analysis of the NOV11a protein yielded the following properties shown in Table 11C.  
               TABLE 11C                       Protein Sequence Properties NOV11a                                        SignalP analysis:   Cleavage site between residues 28 and 29       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 11; pos. chg 2; neg. chg 0           H-region:   length 14; peak value 8.95           PSG score:   4.55                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −2.40           possible cleavage site: between 22 and 23                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 12-28               −2.92                             PERIPHERAL   Likelihood = 2.49 (at 128)                         ALOM score: −2.92 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 19           Charge difference: −4.0 C(−1.0)-N( 3.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 2 (cytoplasmic tail 1 to 12)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   3   Hyd Moment (75):   1.42           Hyd Moment (95):   2.81   G content:   3           D/E content:   1   S/T content:   3                         Score: −3.82       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 36 SRG|LL                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 8.6%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 76.7       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         34.8%: cytoplasmic           30.4%: mitochondrial           13.0%: Golgi           8.7%: endoplasmic reticulum            4.3%: extracellular, including cell wall            4.3%: nuclear            4.3%: vesicles of secretory system                 &gt;&gt; prediction for CG51027-06 is cyt (k = 23)                  
 
      A search of the NOV11a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 11D.  
               TABLE 11D                          Geneseq Results for NOV11a                                         NOV11a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               AAE29924   Human LP289 protein -  Homo sapiens ,   1 . . . 336   332/336 (98%)   0.0           336 aa. [WO200274906-A2, 26-SEP-2002]   1 . . . 336   332/336 (98%)       ABG96271   Human immunoglobulin superfamily   1 . . . 336   332/336 (98%)   0.0           protein IGSFP-9 -  Homo sapiens , 336   1 . . . 336   332/336 (98%)           aa. [WO200272794-A2, 19-SEP-2002]       AAU84386   Novel human secreted or membrane-   1 . . . 336   325/336 (96%)   0.0           associated protein #25 -  Homo sapiens ,   1 . . . 336   329/336 (97%)           336 aa. [WO200204600-A2, 17-JAN-2002]       ABG94639   Human NOV5d protein -  Homo sapiens ,   1 . . . 336   322/336 (95%)   0.0           336 aa. [WO200266643-A2, 29-AUG-2002]   1 . . . 336   326/336 (96%)       ABG94637   Human NOV5b protein -  Homo sapiens ,   18 . . . 336    315/319 (98%)   0.0           319 aa. [WO200266643-A2, 29-AUG-2002]   1 . . . 319   315/319 (98%)                  
 
      In a BLAST search of public sequence databases, the NOV11a protein was found to have homology to the proteins shown in the BLASTP data in Table 11E.  
               TABLE 11E                          Public BLASTP Results for NOV11a                                         NOV11a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q8HW98   Adult male hypothalamus cDNA, RIKEN   12 . . . 336   313/325 (96%)   0.0           full-length enriched library,    1 . . . 325   318/325 (97%)           clone: A230106M20 product: weakly similar           to limbic system-associated membrane           protein precursor (E19S) (CHLAMP, G19-           isoform) -  Mus musculus  (Mouse), 325 aa           (fragment).       P11834   Opioid binding protein/cell adhesion   11 . . . 329   168/328 (51%)   1e−84           molecule precursor (OBCAM) (Opioid-   12 . . . 337   224/328 (68%)           binding cell adhesion molecule) (OPCML) -             Bos taurus  (Bovine), 345 aa.       Q14982   Opioid binding protein/cell adhesion   11 . . . 329   166/328 (50%)   3e−84           molecule precursor (OBCAM) (Opioid-   12 . . . 337   224/328 (67%)           binding cell adhesion molecule) (OPCML) -             Homo sapiens  (Human), 345 aa.       JC1238   opioid-binding protein (clone DUZ1) - rat,   12 . . . 333   163/326 (50%)   5e−83           338 aa.    8 . . . 325   221/326 (67%)       P32736   Opioid binding protein/cell adhesion   11 . . . 333   164/329 (49%)   5e−83           molecule precursor (OBCAM) (Opioid-   12 . . . 332   224/329 (67%)           binding cell adhesion molecule) (OPCML) -             Rattus norvegicus  (Rat), 345 aa.                  
 
      PFam analysis predicts that the NOV11a protein contains the domains shown in the Table 11F.  
               TABLE 11F                          Domain Analysis of NOV11a                                             Identities/                       Similarities           Pfam   NOV11a   for the   Expect           Domain   Match Region   Matched Region   Value                                                 ig    47 . . . 114   16/72 (22%)   0.00065                   40/72 (56%)           ig   147 . . . 197   16/54 (30%)   0.00057                   35/54 (65%)           ig   231 . . . 293   12/66 (18%)   2.7e-05                   45/66 (68%)                      
 
     Example 12.  
      The NOV12 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 12A.  
               TABLE 12A                       NOV12 Sequence Analysis                                                        NOV12a, CG51373-11   SEQ ID NO: 319   3212 bp               DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAG at 2272                       ATG CTGAGCCTCCTCGTCTGGATCCTCACTCTCTCCGATACTTTCTCCCAAGGGACCCAGACCCGCTT           CAGCCAGGAGCCAGCTGACCAGACGGTGGTGGCTGGACAGCGGGCCGTGCTCCCCTGTGTGCTGCTCA       ACTACTCTGGAATTGTGCAATGGACCAAGGACGGGCTGGCCCTGGGCATGGGCCAGGGCCTCAAAGCC       TGGCCACGGTACCGGGTTGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCACAGATGCTGA       GCTCTCTGACGACGCCTCTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGGCGGGCCAAAC       TCACCGTGCTCATCCCCCCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACTGCAGGCAGGC       ACCCCCCACAACCTCACATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCTGGTTCCGGGA       CGGGACGCAGCAGGAGGGCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGGGAGACCACCG       TGAGCCAACTGCTTATTAACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCGAAGCATGAAC       GAAGCCATCCCTAGTGGCAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTACAGTGACCCT       GTCCATTGAGCCACAGACGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCCACAGCCAACC       CCGAGATCTTGGGCTACAGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGAGAGTCGCTAT       GAGACAAATGTGGATTATTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACAAAGTGGGAAG       CACCAATGTCAGCACTTTAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCCAAACCCACAA       CCACAGACATTGGCTCTGATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCTCACTCTCACC       TGGACCAAAAAGGACTCAAATATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTGACTCA       GGCAGACGCTGGCACCTACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGAGGTGC       CGCTCTATGTGAACGGGCCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTGACGGT       GGCAAGGTGGAGTGTTTCATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAGGAGAA       CTTCTTGGAGGTGGGGACCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGTGCTAT       CCACGCTCACCATCAACAATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCTGGAAC       AGCTTCGGGCCAGGCACAGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGGGCATCATAGC       TGGGGCCACCATCGGCGCGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTCTTCCTCTACC       GGCGCCGCAAAGGCAGTCGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGAGACAGTGAAC       CGAGAGCCACTTACGATGCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAGCAACCCGGGT       CATGAAGGCCATCTACTCGTCGTTTAAGGATGATGTGGATCTGAAGCAGGACCTGCGCTGCGACACCA       TCGACACCCGGGAGGAGTATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCGTGCCCATGAA       GACCGCCCGTCTTCCAGGGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCCGCTTCGACGG       CCGCCCCTCATCCCGTCTCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGCCGGGGCCCTG       CCTCTGACTATGGCCCTGAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGACACAACCAGC       CAGCTGTCCTACGAGAACTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTGGGTACCCCAC       CTACCGACTGGGCTACCCCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAGGCGTATGACC       CCATTGGCAAGTACGCCACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTACGGCCAGCGA       TTCCAGCAGCGCATGCAGACTCACGTG TAG   GGGCCAGAGCCTGGCTGGGGCATCTCTGCGGGGCAGAG           GAGAAGGCTTTCGCAGCTGTTCCCTGATATTCAGGGACATTGCTCATTGCTCCCTTCTCGGACCAGCC           TTCTTCCTCCCACCATGGCAGGTGGGGAGCAGGTCTCCCAGAGACACCCCGTCCCGAGGATGGTGCTC           TGTGCATGCCCCAGCCTCCTGGGCCTGCCCTTCCCTCTTCTTCGGGAGGATGTGTCTCTTCTGACCTG           CACTCTTGCCTGACCCTAGAATGGGGACAGGGAAAGTGAAGGTTAGGGAAAGCAGAGGGGGGCACTTT           TTAGCATTCCCTTTCTATCCCACCCCTCTGATCTCCCATAAGTGGAAATGGGGGTACCCAGGGATGGG           CAGGCTTTGGCCTAGGGACATGAAGTATGGGAGTGGGTGGCTGTGGCACAGACAGGTGGAAAACGGGA           TAGCCTGGCCAGTCCCTCTGTTGTCTGCATTCGTGCCCTGGGTGCCTCTCTCCTTCCTCAGGGTACTG           CAGAAGGGAGCGAACAGGGTACTGTTCGCTCTTGTCTACAGAACAGCCCTGGCACTGCATTCAAATCC           AGTCTTCATTCAGCTGGGATCAAAATGCCAGTCACCTTGGCTACCCACTGTGGACAGCTGTCTGTCAG           CATGCAGAGGGATCCAGGAATCCCCCCGGCAGCACGGCCCGCTTTCCTTCTCCTCCATGCTGGGCCAG           CCAGATAAGTCAGGGTCCTGGTGGAGAAAGAAAGGCTAGGACCATGTCCTCATTGACCCAGATACTGC           TGTGTGCTGCACAGCAGTGAACCAACACTAGAGGGAGCCACACAAGCCTCCTCTCCCCAGTCTGCCCC           ACTTCCTGGCTTTAACTCTTGAGCTGGTTTGGGGAGTGGTGAGGTAGGGGTGGGGGTGCTGTAGGCTC           TTTTTCAAAAAAAAAC                                                   NOV12a, CG51373-11   SEQ ID NO: 320   757 aa   MW at 83534.8kD               Protein Sequence                     MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKA           WPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAG       TPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMN       EAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRY       ETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLT       WTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDG       GKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWN       SFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVN       REPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHE       DRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTTS       QLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQR       FQQRIYIQTHV                                             NOV12b, CG51373-10   SEQ ID NO: 321   3430 bp               DNA Sequence   ORF Start: ATG at 351   ORF Stop: TAG at 2490                       CTCTCCGATACTTTCTCCCAAGGGTCAGCTGCTTCTTCATTCCAAGTGGACAAGGAGCCAGCTGCTCA               CTGTCCTTGAGAGACTTCAGCGAGAGACCAGGGTGTCCAGGCTCCATGCAGGAAAGCCATGCGTATAA           ATTCCACCTCTGAGCCAGGCCTCACCAGCAAGCCCACTCTTAAGCCCTTGACTTGGGCTCCAGGGGCC           ATGGGAAGGAGAAACGGACCCAGACCCGCTTCAGCCAGGAGCCAGCTGACCAGACGGTGGTGGCTGGA           CAGCGGGCCGTGCTCCCCTGTGTGCTGCTCAACTACTCTGGAATTGTGCAATGGACCAAGGACGGGCT           GGCCCTGGGC   ATG GGCCAGGCCCTCAAAGCCTGGCCACGGTACCGGGTTGTGGGCTCCGCAGACGCTG       GGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCTCTTACGAGTGCCAGGCCACG       GAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCCCCAGAGGACACCAGGATTGA       CGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCACATGCCGGGCCTTCAATGCGA       AGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGGGCGCTGTGGCCAGCACGGAA       TTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATTAACCCCACGGACCTGGACAT       AGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGGCAAGGAGACTTCCATCGAGC       TGGATGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGACGGTGCAGGAGGGTGAGCGT       GTTGTCTTTACCTGCCAGGCCACAGCCAACCCCGAGATCTTGGGCTACAGGTGGGCCAAAGGGGGTTT       CTTGATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTATTCCTTTTTCACGGAGCCTG       TGTCTTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTTTAGTAAATGTCCACTTTGCT       CCCCGGATTGTAGTTGACCCCAAACCCACAACCACAGACATTGGCTCTGATGTGACCCTTACCTGTGT       CTGGGTTGGGGAAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTCAAATATTGGGGCCCTGGC       TTCTTGGTTCCCCACCCGAGGCTGCTCTCTCTGCCCAGGTCCTGAGTAACAGCAACCAGCTGCTGCTG       AAGTCGGTGACTCAGGCAGACGCTGGCACCTACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGC       TGAGCGGGAGGTGCCGCTCTATGTGAACGGGCCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTG       TGAGGGGTGACGGTGGCAAGGTGGAGTGTTTCATTGGGAGCACACCACCCCCAGACCGCATAGCATGG       GCCTGGAAGGAGAACTTCTTGGAGGTGGGGACCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGG       CAGTGGGGTGCTATCCACGCTCACCATCAACAATGTCATGGAGGCCGACTTTCAGACTCACTACAACT       GCACCGCCTGGAACAGCTTCGGGCCAGGCACAGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCT       GTGGGCATCATAGCTGGGGCCACCATCGGCGCGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGT       ATTCTTCCTCTACCGGCGCCGCAAAGGCAGTCGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGG       TGGAGACAGTGAACCGAGAGCCACTTACGATGCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCC       ACAGCAACCCGGGTCATGAAGGCCATCTACTCGTCGTTTAAGGATGATGTGGATCTGAAGCAGGACCT       GCGCTGCGACACCATCGACACCCGGGAGGAGTATGAGATGAAGGACCCCACCAATGGCTACTACAACG       TGCGTGCCCATGAAGACCGCCCGTCTTCCAGGGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCT       GCCCGCTTCGACGGCCGCCCCTCATCCCGTCTCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTA       TAGCCGGGGCCCTGCCTCTGACTATGGCCCTGAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCA       CTGACACAACCAGCCAGCTGTCCTACGAGAACTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCA       GCTGGGTACCCCACCTACCGACTGGGCTACCCCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATA       TGAGGCGTATGACCCCATTGGCAAGTACGCCACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGG       ACTACGGCCAGCGATTCCAGCAGCGCATGCAGACTCACGTG TAG   GGGCCAGAGCCTGGCTGGGGCATC           TCTGCGGGGCAGAGGAGAAGGCTTTCGCAGCTGTTCCCTGATATTCAGGGACATTGCTCATTGCTCCC           TTCTCGGACCAGCCTTCTTCCTCCCACCATGGCAGGTGGGGAGCAGGTCTCCCAGAGACACCCCGTCC           CGAGGATGGTGCTCTGTGCATGCCCCAGCCTCCTGGGCCTGCCCTTCCCTCTTCTTCGGGAGGATGTG           TCTCTTCTGACCTGCACTCTTGCCTGACCCTAGAATGGGGACAGGGAAAGTGAAGGTTAGGGAAAGCA           GAGGGGGGCACTTTTTAGCATTCCCTTTCTATCCCACCCCTCTGATCTCCCATAAGTGGAAATGGGGC           TACCCAGGGATGGGCAGGCTTTGGCCTAGGGACATGAAGTATGGGAGTGGGTGGCTGTGGCACAGACA           GGTGGAAAACGGGATAGCCTGGCCAGTCCCTCTGTTGTCTGCATTCGTGCCCTGGGTGCCTCTCTCCT           TCCTCAGGGTACTGCAGAAGGGAGCGAACAGGGTACTGTTCGCTCTTGTCTACAGAACAGCCCTGGCA           CTGCATTCAAATCCAGTCTTCATTCAGCTGGGATCAAAATGCCAGTCACCTTGGCTACCCACTGTGGA           CAGCTGTCTGTCAGCATGCAGAGGGATCCAGGAATCCCCCCGGCAGCACGGCCCGCTTTCCTTCTCCT           CCATGCTGGGCCAGCCAGATAAGTCAGGGTCCTGGTGGAGAAAGAAAGGCTAGGACCATGTCCTCATT           GACCCAGATACTGCTGTGTGCTGCACAGCAGTGAACCAACACTAGAGGGAGCCACACAAGCCTCCTCT           CCCCAGTCTGCCCCACTTCCTGGCTTTAACTCTTGAGCTGGTTTGGGGAGTGGTGAGGTAGGGGTGGG           GGTGCTGTAGGCTCTTTTTCAAAAAAAAAC                                                   NOV12b, CG51373-10   SEQ ID NO: 322   713 aa   MW at 78491.0kD               Protein Sequence                     MGQALKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGP           VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV       FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPETLGYRWAKGGFLIE       DAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVG       EIPPSLSPGPKRTQILGPWLLGSPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAERE       VPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGV       LSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASTLLIFFFIALVFFL       YRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCD       TIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRG       PASDYGPEPTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAY       DPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV                                             NOV12c, CG51373-08   SEQ ID NO: 323   2128 bp               DNA Sequence   ORF Start: ATG at 31   ORF Stop: TAG at 2119                       CAATGGACCAAGGACGGGCTGGCCCTGGGC   ATG GGCCAGGGCCTCAAAGCCTGGCCACGGTACCGGGT           TGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCT       CTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCC       CCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCAC       ATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGG       GCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATT       AACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGG       CAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGA       CGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCCACAGCCAACCCCGAGATCTTGGACTAC       AGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTA       TTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTT       TAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCCAAACCCACAACCACAGACATTGGCTCT       GATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTC       AAATATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCTGGCACCT       ACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGTGAACGGG       CCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGGAGTGTTT       CATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAGGTGGGGA       CCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCACCATCAAC       AATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGCCAGGCAC       AGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGGGCATCATAGCTGGGGCCACCATCGGCG       CGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTCTTCCTCTACCGGCGCCGCAAAGGCAGT       CGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCACTTACGAT       GCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCCATCTACT       CGTCGTTTATGGATGATGTGGATCTGAAGCAGGACCTGCGCTGCGACACCATCGACACCCGGGAGGAG       TATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGTCTTCCAG       GGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCATCCCGTC       TCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTATGGCCCT       GAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCTACGAGAA       CTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTGGGCTACC       CCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAGGCGTATGACCCCATTGGCAAGTACGCC       ACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGCGCATGCA       GACTCACGTG TAG   GGGCCAG                                                   NOV12c, CG51373-08   SEQ ID NO: 324   696 aa   MW at 76975.3kD               Protein Sequence                     MGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGP           VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV       FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILDYRWAKGGFLIE       DAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVG       NPPLTLTWTKKDSNNVLSNSNQLLLKSVTQADAGTYTCHAIVPRIGVAEREVPLYVNGPPIISSEAVQ       YAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTH       YNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLD       IKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFMDDVDLKQDLRCDTIDTREEYEMKDPTNGY       YNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAP       AGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQ       HSDYGQRFQQRMQTHV                                             NOV12d, 237582097   SEQ ID NO: 325   2100 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GGATCCATGGGCCAGGGCCTCAAAGCCTGGCCACGGTACCGGGTTGTGGGCTCCGCAGACGCTGGGCA           GTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCTCTTACGAGTGCCAGGCCACGGAGG       CCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCCCCAGAGGACACCAGGATTGACGGA       GGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCACATGCCGGGCCTTCAATGCGAAGCC       TGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGGGCGCTGTGGCCAGCACGGAATTGC       TGAAGGATGGGAAGAGGGAGAACACCGTGAGCCAACTGCTTATTAACCCCACGGACCTGGACATAGGG       CGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGGCAAGGAGACTTCCATCGAGCTGGA       TGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGACGGTGCAGGAGGGTGAGCGTGTTG       TCTTTACCTGCCAGGCCACAGCCAACCCCGAGATCTTGGACTACAGGTGGGCCAAAGGGGGTTTCTTG       ATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTATTCCTTTTTCACGGAGCCTGTGTC       TTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTTTAGTAAATGTCCACTTTGCTCCCC       GGATTGTAGTTGACCCCAAACCCACAACCACAGACATTGGCTCTGATGTGACCCTTACCTGTGTCTGG       GTTGGGAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTCAAATATGGTCCTGAGTAACAGCAA       CCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCTGGCACCTACACCTGCCGGGCCATCGTGCCTC       GAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGTGAACGGGCCCCCCATCATCTCCAGTGAGGCA       GTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGGAGTGTTTCATTGGGAGCACACCACCCCCAGA       CCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAGGTGGGGACCCTGGAACGCTATACAGTGGAGA       GGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCACCATCAACAATGTCATGGAGGCCGACTTTCAG       ACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGCCAGGCACAGCCATCATCCAGCTGGAAGAGCG       AGAGGTGTTACCTGTGGGCATCATAGCTGGGGCCACCATCGGCGCGAGCATCCTGCTCATCTTCTTCT       TCATCGCCTTGGTATTCTTCCTCTACCGGCGCCGCAAAGGCAGTCGCAAAGACGTGACCCTGAGGAAG       CTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCACTTACGATGCATTCTGACCGGGAGGATGACAC       CGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCCATCTACTCGTCGTTTATGGATGATGTGGATC       TGAAGCAGGACCTGCGCTGCGACACCATCGACACCCGGGAGGAGTATGAGATGAAGGACCCCACCAAT       GGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGTCTTCCAGGGCAGTGCTCTATGCTGACTACCG       TGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCATCCCGTCTCTCCCACTCCAGCGGCTATGCCC       AGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTATGGCCCTGAGCCCACACCCCCTGGCCCTGCT       GCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCTACGAGAACTATGAGAAGTTCAACTCCCATCC       CTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTGGGCTACCCCCAGGCCCCACCCTCTGGCCTGG       AGCGGACCCCATATGAGGCGTATGACCCCATTGGCAAGTACGCCACAGCCACTCGATTCTCCTACACC       TCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGCGCATGCAGACTCACGTGCTCGAG                                                 NOV12d, 237582097   SEQ ID NO: 326   700 aa   MW at 77361.7kD               Protein Sequence                     GSMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRPAKLTVLIPPEDTRIDG           GPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIG       RVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILDYRWAKGGFL       IEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVW       VGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEA       VQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQ       THYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRK       LDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFMDDVDLKQDLRCDTIDTREEYEMKDPTN       GYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPA       APAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYT       SQHSDYGQRFQQRMQTHVLE                                             NOV12e, 294385961   SEQ ID NO: 327   2290 bp               DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAAGCTTATGCTGAGCCTCCTCGTCTGGATCCTCACTCTCTCCGATACTTTCTCCCAAGGGACCC           AGACCCGCTTCAGCCAGGAGCCAGCTGACCAGACGGTGGTGGCTGGACAGCGGGCCGTGCTCCCCTGT       GTGCTGCTCAACTACTCTGGAATTGTGCAATGGACCAAGGACGGGCTGGCCCTGGGCATGGGCCAGGG       CCTCAAAGCCTGGCCACGGTACCGGGTTGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCA       CAGATGCTGAGCTCTCTGACGACGCCTCTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGG       CGGGCCAAACTCACCGTGCTCATCCCCCCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACT       GCAGGCAGGCACCCCCCACAACCTCACATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCT       GGTTCCGGGACGGGACGCAGCAGGAGGGCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGG       GAGACCACCGTGAGCCAACTGCTTATTAACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCG       AAGCATGAACGAAGCCATCCCTAGTGGCAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTA       CAGTGACCCTGTCCATTGAGCCACAGACGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCC       ACAGCCAACCCGGAGATCTTGGGCTACAGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGA       GAGTCGCTATGAGACAAATGTGGATTATTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTCCACAACA       AAGTGGGAAGCACCAATGTCAGCACTTTAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCC       AAACCCACAACCACAGACATTGGCTCTGATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCT       CACTCTCACCTGGACCAAAAAGGACTCAAATATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGT       CGGTGACTCAGGCAGACGCTGGCACCTACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAG       CGGGAGGTGCCGCTCTATGTGAACGGGCCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAG       GGGTGACGGTGGCAAGGTGGAGTGTTTCATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCT       GGAAGGAGAACTTCTTGGAGGTGGGGACCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGT       GGGGTGCTATCCACGCTCACCATCAACAATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCAC       CGCCTGGAACAGCTTCGGGCCAGGCACAGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGG       GCATCATAGCTGGGGCCACCATCGGCGCGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTC       TTCCTCTACCGGCGCCGCAAAGGCAGTCGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGA       GACAGTGAACCGAGAGCCACTTACGATGCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAG       CAACCCGGGTCATGAAGGCCATCTACTCGTCGTTTAAGGATGATGTGGATCTGAAGCAGGACCTGCGC       TGCGACACCATCGACACCCGGGAGGAGTATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCG       TGCCCATGAAGACCGCCCGTCTTCCAGGGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCC       GCTTCGACGGCCGCCCCTCATCCCGTCTCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGC       CGGGGCCCTGCCTCTGACTATGGCCCTGAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGA       CACAACCAGCCAGCTGTCCTACGAGAACTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTG       GGTACCCCACCTACCGACTGGGCTACCCCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAG       GCGTATGACCCCATTGGCAAGTACGCCACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTA       CGGCCAGCGATTCCAGCAGCGCATGCAGACTCACGTGGTCGACGGC                                                 NOV12e, 294385961   SEQ ID NO: 328   763 aa   MW at 84148.5kD               Protein Sequence                     TKLMLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQG           LKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILL       QAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCR       SMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHE       SRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPL       TLTWTKKDSNNVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVR       GDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCT       AWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVE       TVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVR       AHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTD       TTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDY       GQRFQQRMQTHVVDG                                             NOV12f, 294398021   SEQ ID NO: 329   2336 bp               DNA Sequence   ORF Start: at 2   ORF Stop: at 2336                       C ACCAAGCTTATGCTGAGCCTCCTCGTCTGGATCCTCACTCTCTCCGATACTTTCTCCCAAGGGACCC           AGACCCGCTTCAGCCAGGAGCCAGCTGACCAGACGGTGGTGGCTGGACAGCGGGCCGTGCTCCCCTGT       GTGCTGCTCAACTACTCTGGAATTGTGCAATGGACCAAGGACGGGCTGGCCCTGGGCATGGGCCAGGG       CCTCAAAGCCTGGCCACGGTACCGGGTTGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCA       CAGATGCTGAGCTCTCTGACGACGCCTCTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGG       CGGGCCAAACTCACCGTGCTCATCCCCCCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACT       GCAGGCAGGCACCCCCCACAACCTCACATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCT       GGTTCCGGGACGGGACGCAGCAGGAGGGCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGG       GAGACCACCGTGAGCCAACTGCTTATTAACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCG       AAGCATGAACGAAGCCATCCCTAGTGGCAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTA       CAGTGACCCTGTCCATTGAGCCACAGACGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCC       ACAGCCAACCCCGAGATCTTGGGCTACAGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGA       GAGTCGCTATGAGACAAATGTGGATTATTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACA       AAGTGGGAAGCACCAATGTCAGCACTTTAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCC       AAACCCACAACCACAGACATTGGCTCTGATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCT       CACTCTCACCTGGACCAAAAAGGACTCAAATATGGGGCCCAGGCCTCCTGGCTCCCCACCCGAGGCTG       CTCTCTCTGCCCAGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCT       GGCACCTACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGT       GAACGGGCCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGG       AGTGTTTCATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAG       GTGGGGACCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCAC       CATCAACAATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGC       CAGGCACAGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGGGCATCATAGCTGGGGCCACC       ATCGGCGCGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTCTTCCTCTACCGGCGCCGCAA       AGGCAGTCGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCAC       TTACGATGCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCC       ATCTACTCGTCGTTTAAGGATGATGTGGATCTGAAGCAGGACCTGCGCTGCGACACCATCGACACCCG       GGAGGAGTATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGT       CTTCCAGGGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCA       TCCCGTCTCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTA       TGGCCCTGAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCT       ACGAGAACTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTG       GGCTACCCCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAGGCGTATGACCCCATTGGCAA       GTACGCCACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGC       GCATGCAGACTCACGTGGTCGACG                                                 NOV12f, 294398021   SEQ ID NO: 330   778 aa   MW at 85605.1kD               Protein Sequence                     TKLMLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQPAVLPCVLLNYSGIVQWTKDGLALGMGQG           LKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILL       QAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCR       SMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHE       SRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPL       TLTWTKKDSNMGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYV       NGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLT       INNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRK       GSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTR       EEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDY       GPEPTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGK       YATATRFSYTSQHSDYGQRFQQRMQTHVVD                                             NOV12g, CG51373-01   SEQ ID NO: 331   1230 bp               DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAA at 1003                       ATG CATTTGACTCTGGAAGTCTTAAACCATGGCCCCTTCCCTCTAAACCTTTCCTCCATTGCTTACAA           TCATGGAACTGTGTTTGGCCACTGGAAGAATAACGTCACTCGGGAAACGCTGGTGAAAGTAAAAGATG       CTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGGAAGGAAACATTT       CTGGTGAATGAGGAGGCAACGGGCGAGACCTCAGGAGACAATGTTGTTCATTCTAGGAATCTGTCTCA       GACAATCTTCATCACCCGGAAACGATGGGAGGGGACCCAGACCCGCTTCAGCCAGGAGCCAGCTGACC       AGACGGTGGTGGCTGGACAGCGGGCCGTGCTCCCCTGTGTGCTGCTCAACTACTCTGGAATTGTGCAA       TGGACCAAGGACGGGCTGGCCCTGGGCATGGGCCAGGCCCTCAAAGCCTGGCCACGGTACCGGGTTGT       GGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCTCTT       ACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCCCCA       GAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCACATG       CCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGGGCG       CTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATTAAC       CCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGGCAA       GGAGACTTCCATCGAGCTGGATGTGCACCGTGAGTGGGCTGGGGGGAGCAGTCTGGAGCAGGGGGGTG       GAAGAAGGGGTGTGTTTGAGAAGCACACTCTTAGTTTGAGAAACACAAAC TAA   GAGTCCCCCTATGGT           CCCCAGGACAAACGCTTGCCTTCTTCACATCTTTCATTCCCTGGATTGAACCATGGGGACTAAGGGCT           GGTAGAGCATTGGCTGTGGAGTCAGGCAGTCCCCAGGTCTAAACCAGCCTGTTATTAGTCAATGGTTT           ACACTCTCTGGGCCTCGGTTTCCAGTTCTGTATACTGTATATTGCAAAAGATAAAATACTGGCCTACA           GCCCCA                                                   NOV12g, CG51373-01   SEQ ID NO: 332   334 aa   MW at 36655.8kD               Protein Sequence                     MHLTLEVLNHGPFPLNLSSIAYNHGTVFGHWKNNVTRETLVKVKDAEDQLGARVGYIELDLNSGKETF           LVNEEATGETSGDNVVHSRNLSQTIFITRKRWEGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQ       WTKDGLALGMGQALKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPP       EDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLIN       PTDLDIGRVFTCRSMNEAIPSGKETSIELDVHREWAGGSSLEQGGGRRGVFEKHTLSLRNTN                                             NOV12h, CG51373-02   SEQ ID NO: 333   3464 bp               DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAG at 2524                       ATG CATTTGACTCTGGAAGTCTTAAACCATGGCCCCTTCCCTCTAAACCTTTCCTCCATTGCTTACAA           TCATGGAACTGTGTTTGGCCACTGGAAGAATAACGTCACTCGGGAAACGCTGGTGAAAGTAAAAGATG       CTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGGAAGGAAACATTT       CTGGTGAATGAGGAGGCAACGGGCGAGACCTCAGGAGACAATGTTGTTCATTCTAGGAATCTGTCTCA       GACAATCTTCATCACCCGGAAACGATGGGAGGGGACCCAGACCCGCTTCAGCCAGGAGCCAGCTGACC       AGACGGTGGTGGCTGGACAGCGGGCCGTGCTCCCCTGTGTGCTGCTCAACTACTCTGGAATTGTGCAA       TGGACCAAGGACGGGCTGGCCCTGGGCATGGGCCAGGCCCTCAAAGCCTGGCCACGGTACCGGGTTGT       GGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCTCTT       ACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCCCCA       GAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCACATG       CCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGGGCG       CTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATTAAC       CCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGGCAA       GGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGACGG       TGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCCACAGCCAACCCCGAGATCTTGGGCTACAGG       TGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTATTC       CTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTTTAG       TAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCCAAACCCACAACCACAGACATTGGCTCTGAT       GTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTCAAA       TATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCTGGCACCTACA       CCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGTGAACGGGCCC       CCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGGAGTGTTTCAT       TGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAGGTGGGGACCC       TGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCACCATCAACAAT       GTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGCCAGGCACAGC       CATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGGGCATCATAGCTGGGGCCACCATCGGCGCGA       GCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTCTTCCTCTACCGGCGCCGCAAAGGCAGTCGC       AAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCACTTACGATGCA       TTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCCATCTACTCGT       CGTTTAAGGATGATGTGGATCTGAAGCAGGACCTGCGCTGCGACACCATCGACACCCGGGAGGAGTAT       GAGATGAAGGACCCCACCAATGGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGTCTTCCAGGGC       AGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCATCCCGTCTCT       CCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTATGGCCCTGAG       CCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCTACGAGAACTA       TGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTGGGCTACCCCC       AGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAGGCGTATGACCCCATTGGCAAGTACGCCACA       GCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGCGCATGCAGAC       TCACGTG TAG   GGGCCAGAGCCTGGCTGGGGCATCTCTGCGGGGCAGAGGAGAAGGCTTTCGCAGCTGT           TCCCTGATATTCAGGGACATTGCTCATTGCTCCCTTCTCGGACCAGCCTTCTTCCTCCCACCATGGCA           GGTGGGGAGCAGGTCTCCCAGAGACACCCCGTCCCGAGGATGGTGCTCTGTGCATGCCCCAGCCTCCT           GGGCCTGCCCTTCCCTCTTCTTCGGGAGGATGTGTCTCTTCTGACCTGCACTCTTGCCTGACCCTAGA           ATGGGGACAGGGAAAGTGAAGGTTAGGGAAAGCAGAGGGGGGCACTTTTTAGCATTCCCTTTCTATCC           CACCCCTCTGATCTCCCATAAGTGGAAATGGGGGTACCCAGGGATGGGCAGGCTTTGGCCTAGGGACA           TGAAGTATGGGAGTGGGTGGCTGTGGCACAGACAGGTGGAAAACGGGATAGCCTGGCCAGTCCCTCTG           TTGTCTGCATTCGTGCCCTGGGTGCCTCTCTCCTTCCTCAGGGTACTGCAGAAGGGAGCGAACAGGGT           ACTGTTCGCTCTTGTCTACAGAACAGCCCTGGCACTGCATTCAAATCCAGTCTTCATTCAGCTGGGAT           CAAAATGCCAGTCACCTTGGCTACCCACTGTGGACAGCTGTCTGTCAGCATGCAGAGGGATCCAGGAA           TCCCCCCGGCAGCACGGCCCGCTTTCCTTCTCCTCCATGCTGGGCCAGCCAGATAAGTCAGGGTCCTG           GTGGAGAAAGAAAGGCTAGGACCATGTCCTCATTGACCCAGATACTGCTGTGTGCTGCACAGCAGTGA           ACCAACACTAGAGGGAGCCACACAAGCCTCCTCTCCCCAGTCTGCCCCACTTCCTGGCTTTAACTCTT           GAGCTGGTTTGGGGAGTGGTGAGGTAGGGGTGGGGGTGCTGTAGGCTCTTTTTCAAAAAAAAAC                                                   NOV12h, CG51373-02   SEQ ID NO: 334   841 aa   MW at 92988.2kD               Protein Sequence                     MHLTLEVLNHGPFPLNLSSIAYNHGTVFGHWKNNVTRETLVKVKDAEDQLGARVGYIELDLNSGKETF           LVNEEATGETSGDNVVHSRNLSQTIFITRKRWEGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQ       WTKDGLALGMGQALKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPP       EDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLIN       PTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYR       WAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSD       VTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGP       PIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINN       VMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSR       KDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEY       EMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPE       PTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYAT       ATRFSYTSQHSDYGQRFQQRMQTHV                                             NOV12i, CG51373-03   SEQ ID NO: 335   3379 bp               DNA Sequence   ORF Start: ATG at 351   ORF Stop: TAG at 2439                       CTCTCCGATACTTTCTCCCAAGGGTCAGCTGCTTCTTCATTCCAAGTGGACAAGGAGCCAGCTGCTCA               CTGTCCTTGAGAGACTTCAGCGAGAGACCAGGGTGTCCAGGCTCCATGCAGGAAAGCCATGCGTATAA           ATTCCACCTCTGAGCCAGGCCTCACCAGCAAGCCCACTCTTAAGCCCTTGACTTGGGCTCCAGGGGCC           ATGGGAAGGAGAAACGGACCCAGACCCGCTTCAGCCAGGAGCCAGCTGACCAGACGGTGGTGGCTGGA           CAGCGGGCCGTGCTCCCCTGTGTGCTGCTCAACTACTCTGGAATTGTGCAATGGACCAAGGACGGGCT           GGCCCTGGGC   ATG GGCCAGGCCCTCAAAGCCTGGCCACGGTACCGGGTTGTGGGCTCCGCAGACGCTG       GGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCTCTTACGAGTGCCAGGCCACG       GAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCCCCAGAGGACACCAGGATTGA       CGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCACATGCCGGGCCTTCAATGCGA       AGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGGGCGCTGTGGCCAGCACGGAA       TTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATTAACCCCACGGACCTGGACAT       AGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGGCAAGGAGACTTCCATCGAGC       TGGATGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGACGGTGCAGGAGGGTGAGCGT       GTTGTCTTTACCTGCCAGGCCACAGCCAACCCCGAGATCTTGGGCTACAGGTGGGCCAAAGGGGGTTT       CTTGATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTATTCCTTTTTCACGGAGCCTG       TGTCTTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTTTAGTAAATGTCCACTTTGCT       CCCCGGATTGTAGTTGACCCCAAACCCACAACCACAGACATTGGCTCTGATGTGACCCTTACCTGTGT       CTGGGTTGGGAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTCAAATATGGTCCTGAGTAACA       GCAACCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCTGGCACCTACACCTGCCGGGCCATCGTG       CCTCGAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGTGAACGGGCCCCCCATCATCTCCAGTGA       GGCAGTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGGAGTGTTTCATTGGGAGCACACCACCCC       CAGACCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAGGTGGGGACCCTGGAACGCTATACAGTG       GAGAGGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCACCATCAACAATGTCATGGAGGCCGACTT       TCAGACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGCCAGGCACAGCCATCATCCAGCTGGAAG       AGCGAGAGGTGTTACCTGTGGGCATCATAGCTGGGGCCACCATCGGCGCGAGCATCCTGCTCATCTTC       TTCTTCATCGCCTTGGTATTCTTCCTCTACCGGCGCCGCAAAGGCAGTCGCAAAGACGTGACCCTGAG       GAAGCTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCACTTACGATGCATTCTGACCGGGAGGATG       ACACCGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCCATCTACTCGTCGTTTAAGGATGATGTG       GATCTGAAGCAGGACCTGCGCTGCGACACCATCGACACCCGGGAGGAGTATGAGATGAAGGACCCCAC       CAATGGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGTCTTCCAGGGCAGTGCTCTATGCTGACT       ACCGTGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCATCCCGTCTCTCCCACTCCAGCGGCTAT       GCCCAGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTATGGCCCTGAGCCCACACCCCCTGGCCC       TGCTGCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCTACGAGAACTATGAGAAGTTCAACTCCC       ATCCCTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTGGGCTACCCCCAGGCCCCACCCTCTGGC       CTGGAGCGGACCCCATATGAGGCGTATGACCCCATTGGCAAGTACGCCACAGCCACTCGATTCTCCTA       CACCTCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGCGCATGCAGACTCACGTG TAG   GGGCCAG           AGCCTGGCTGGGGCATCTCTGCGGGGCAGAGGAGAAGGCTTTCGCAGCTGTTCCCTGATATTCAGGGA           CATTGCTCATTGCTCCCTTCTCGGACCAGCCTTCTTCCTCCCACCATGGCAGGTGGGGAGCAGGTCTC           CCAGAGACACCCCGTCCCGAGGATGGTGCTCTGTGCATGCCCCAGCCTCCTGGGCCTGCCCTTCCCTC           TTCTTCGGGAGGATGTGTCTCTTCTGACCTGCACTCTTGCCTGACCCTAGAATGGGGACAGGGAAAGT           GAAGGTTAGGGAAAGCAGAGGGGGGCACTTTTTAGCATTCCCTTTCTATCCCACCCCTCTGATCTCCC           ATAAGTGGAAATGGGGGTACCCAGGGATGGGCAGGCTTTGGCCTAGGGACATGAAGTATGGGAGTGGG           TGGCTGTGGCACAGACAGGTGGAAAACGGGATAGCCTGGCCAGTCCCTCTGTTGTCTGCATTCGTGCC           CTGGGTGCCTCTCTCCTTCCTCAGGGTACTGCAGAAGGGAGCGAACAGGGTACTGTTCGCTCTTGTCT           ACAGAACAGCCCTGGCACTGCATTCAAATCCAGTCTTCATTCAGCTGGGATCAAAATGCCAGTCACCT           TGGCTACCCACTGTGGACAGCTGTCTGTCAGCATGCAGAGGGATCCAGGAATCCCCCCGGCAGCACGC           CCCGCTTTCCTTCTCCTCCATGCTGGGCCAGCCAGATAAGTCAGGGTCCTGGTGGAGAAAGAAAGGCT           AGGACCATGTCCTCATTGACCCAGATACTGCTGTGTGCTGCACAGCAGTGAACCAACACTAGAGGGAG           CCACACAAGCCTCCTCTCCCCAGTCTGCCCCACTTCCTGGCTTTAACTCTTGAGCTGGTTTGGGGAGT           GGTGAGGTAGGGGTGGGGGTGCTGTAGGCTCTTTTTCAAAAAAAAAC                                                   NOV12i, CG51373-03   SEQ ID NO: 336   696 aa   MW at 76928.3kD               Protein Sequence                     MGQALKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGP           VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV       FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIE       DAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVG       NPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQ       YAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTH       YNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLD       IKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGY       YNVRAHEDRPSSRAVLYADYRAPGPARFDQRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAP       AGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQ       HSDYGQRFQQRMQTHV                                             NOV12i, CG51373-04   SEQ ID NO: 337   1145 bp               DNA Sequence   ORF Start: ATG at 351   ORF Stop: TAA at 918                       CTCTCCGATACTTTCTCCCAAGGGTCAGCTGCTTCTTCATTCCAAGTGGACAAGGAGCCAGCTGCTCA               CTGTCCTTGAGAGACTTCAGCGAGAGACCAGGGTGTCCAGGCTCCATGCAGGAAAGCCATGCGTATAA           ATTCCACCTCTGAGCCAGGCCTCACCAGCAAGCCCACTCTTAAGCCCTTGACTTGGGCTCCAGGGGCC           ATGGGAAGGAGAAACGGACCCAGACCCGCTTCAGCCAGGAGCCAGCTGACCAGACGGTGGTGGCTGGA           CAGCGGGCCGTGCTCCCCTGTGTGCTGCTCAACTACTCTGGAATTGTGCAATGGACCAAGGACGGGCT           GGCCCTGGGC   ATG GGCCAGGCCCTCAAAGCCTGGCCACGGTACCGGGTTGTGGGCTCCGCAGACGCTG       GGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCTCTTACGAGTGCCAGGCCACG       GAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCCCCAGAGGACACCAGGATTGA       CGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCACATGCCGGGCCTTCAATGCGA       AGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGGGCGCTGTGGCCAGCACGGAA       TTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATTAACCCCACGGACCTGGACAT       AGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGGCAAGGAGACTTCCATCGAGC       TGGATGTGCACCGTGAGTGGGCTGGGGGGAGCAGTCTGGAGCAGGGGGGTGGAAGAAGGGGTGTGTTT       GAGAAGCACACTCTTAGTTTGAGAAACACAAAC TAA   GAGTCCCCCTATGGTCCCCAGGACAAACGCTT           GCCTTCTTCACATCTTTCATTCCCTGGATTGAACCATGGGGACTAAGGGCTGGTAGAGCATTGGCTGT           GGAGTCAGGCAGTCCCCAGGTCTAAACCAGCCTGTTATTAGTCAATGGTTTACACTCTCTGGGCCTCG           GTTTCCAGTTCTGTATACTGTATATTGCAAAAGATAAAATACTGGCCTACAGCCCCA                                                   NOV12j, CG51373-04   SEQ ID NO: 338   189 aa   MW at 20595.8kD               Protein Sequence                     MGQALKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGP           VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV       FTCRSMNEAIPSGKETSIELDVHREWAGGSSLEQGGGRRGVFEKHTLSLRNTN                                             NOV12k, CG51373-05   SEQ ID NO: 339   1148 bp               DNA Sequence   ORF Start: ATG at 351   ORF Stop: TAA at 918                       CTCTCCGATACTTTCTCCCAAGGGTCAGCTGCTTCTTCATTCCAAGTGGACAAGGAGCCAGCTGCTCA               CTGTCCTTGAGAGACTTCAGCGAGAGACCAGGGTGTCCAGGCTCCATGCAGGAAAGCCATGCGTATAA           ATTCCACCTCTGAGCCAGGCCTCACCAGCAAGCCCACTCTTAAGCCCTTGACTTGGGCTCCAGGGGCC           ATGGGAAGGAGAAACGGACCCAGACCCGCTTCAGCCAGGAGCCAGCTGACCAGACGGTGGTGGCTGGA           CAGCGGGCCGTGCTCCCCTGTGTGCTGCTCAACTACTCTGGAATTGTGCAATGGACCAAGGACGGGCT           GGCCCTGGGC   ATG GGCCAGGCCCTCAAAGCCTGGCCACGGTACCGGGTTGTGGGCTCCGCAGACGCTG       GGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCTCTTACGAGTGCCAGGCCACG       GAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCCCCAGAGGACACCAGGATTGA       CGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCACATGCCGGGCCTTCAATGCGA       AGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGGGCGCTGTGGCCAGCACGGAA       TTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATTAACCCCACGGACCTGGACAT       AGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGGCAAGGAGACTTCCATCGAGC       TGGATGTGCACCGTGAGTGGGCTGGGGGGAGCAGTCTGGAGCAGGGGGGTGGAAGAAGGGGTGTGTTT       GAGAAGCACACTCTTAGTTTGAGAAACACAAAC TAA   GAGTCCCCCTATGGTCCCCAGGACAAACGCTT           GCCTTCTTCACATCTTTCATTCCCTGGATTGAACCATGGGGACTAAGGGCTGGTAGAGCATTGGCTGT           GGAGTCAGGCAGTCCCCAGGTCTAAACCAGCCTGTTATTAGTCAATGGTTTACACTCTCTGGGCCTCG           GTTTCCAGTTCTGTATACTGTATATTGCAAAAGATAAAATACTGGCCTACAGCCCCAAAA                                                   NOV12k, CG51373-05   SEQ ID NO: 340   189 aa   MW at 20595.8kD               Protein Sequence                     MGQALKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGP           VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV       FTCRSMNEAIPSGKETSIELDVHREWAGGSSLEQGGGRRGVFEKHTLSLRNTN                                             NOV12l, CG51373-06   SEQ ID NO: 341   1148 bp               DNA Sequence   ORF Start: ATG at 351   ORF Stop: TAA at 918                       CTCTCCGATACTTTCTCCCAAGGGTCAGCTGCTTCTTCATTCCAAGTGGACAAGGAGCCAGCTGCTCA               CTGTCCTTGAGAGACTTCAGCGAGAGACCAGGGTGTCCAGGCTCCATGCAGGAAAGCCATGCGTATAA           ATTCCACCTCTGAGCCAGGCCTCACCAGCAAGCCCACTCTTAAGCCCTTGACTTGGGCTCCAGGGGCC           ATGGGAAGGAGAAACGGACCCAGACCCGCTTCAGCCAGGAGCCAGCTGACCAGACGGTGGTGGCTGGA           CAGCGGGCCGTGCTCCCCTGTGTGCTGCTCAACTACTCTGGAATTGTGCAATGGACCAAGGACGGGCT           GGCCCTGGGC   ATG GGCCAGGCCCTCAAAGCCTGGCCACGGTACCGGGTTGTGGGCTCCGCAGACGCTG       GGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCTCTTACGAGTGCCAGGCCACG       GAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCCCCAGAGGACACCAGGATTGA       CGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCACATGCCGGGCCTTCAATGCGA       AGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGGGCGCTGTGGCCAGCACGGAA       TTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATTAACCCCACGGACCTGGACAT       AGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGGCAAGGAGACTTCCATCGAGC       TGGATGTGCACCGTGAGTGGGCTGGGGGGAGCAGTCTGGAGCAGGGGGGTGGAAGAAGGGGTGTGTTT       GAGAAGCACACTCTTAGTTTGAGAAACACAAAC TAA   GAGTCCCCCTATGGTCCCCAGGACAAACGCTT           GCCTTCTTCACATCTTTCATTCCCTGGATTGAACCATGGGGACTAAGGGCTGGTAGAGCATTGGCTGT           GGAGTCAGGCAGTCCCCAGGTCTAAACCAGCCTGTTATTAGTCAATGGTTTACACTCTCTGGGCCTCG           GTTTCCAGTTCTGTATACTGTATATTGCAAAAGATAAAATACTGGCCTACAGCCCCAAAA                                                   NOV12l, CG51373-06   SEQ ID NO: 342   189 aa   MW at 20595.8kD               Protein Sequence                     MGQALKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGP           VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV       FTCRSMNEAIPSGKETSIELDVHREWAGGSSLEQGGGRRGVFEKHTLSLRNTN                                             NOV12m, CG51373-07   SEQ ID NO: 343   1407 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     CGCTTCAGCCAGGAGCCAGCTGACCAGACGGTGGTGGCTGGACAGCGGGCCGTGCTCCCCTGTGTGCT           GCTCAACTACTCTGGAATTGTGCAATGGACCAAGGACGGGCTGGCCCTGGGCATGGGCCAGGCCCTCA       AAGCCTGGCCACGGTACCGGGTTGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCACAGAT       GCTGAGCTCTCTGACGACGCCTCTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGGCGGGC       CAAACTCACCGTGCTCATCCCCCCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACTGCAGG       CAGGCACCCCCCACAACCTCACATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCTGGTTC       CGGGACGGGACGCAGCAGGAGGGCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGGGAGAC       CACCGTGAGCCAACTGCTTATTAACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCGAAGCA       TGAACGAAGCCATCCCTAGTGGCAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTACAGTG       ACCCTGTCCATTGAGCCACAGACGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCCACAGC       CAACCCCGAGATCTTGGGCTACAGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGAGAGTC       GCTATGAGACAAATGTGGATTATTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACAAAGTG       GGAAGCACCAATGTCAGCACTTTAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCCAAACC       CACAACCACAGACATTGGCTCTGATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCTCACTC       TCACCTGGACCAAAAAGGACTCAAATATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTG       ACTCAGGCAGACGCTGGCACCTACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGA       GGTGCCGCTCTATGTGAACGGGCCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTG       ACGGTGGCAAGGTGGAGTGTTTCATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAG       GAGAACTTCTTGGAGGTGGGGACCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGT       GCTATCCACGCTCACCATCAACAATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCT       GGAACAGCTTCGGGCCAGGCACAGCCATCATCCAGCTGGAAGAGCGA                                                 NOV12m, CG51373-07   SEQ ID NO: 344   469 aa   MW at 51246.2kD               Protein Sequence                     RFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQALKAWPRYRVVGSADAGQYNLEITD           AELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWF       RDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTV       TLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKV       GSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSV       TQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWK       ENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEER                                             NOV12n, CG51373-09   SEQ ID NO: 345   2128 bp               DNA Sequence   ORF Start: ATG at 31   ORF Stop: TAG at 2119                       CAATGGACCAAGGACGGGCTGGCCCTGGGC   ATG GGCCAGGGCCTCAAAGCCTGGCCACGGTACCGGGT           TGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCT       CTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCC       CCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCAC       ATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGG       GCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATT       AACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGG       CAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGA       CGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCCACAGCCAACCCCGAGATCTTGGACTAC       AGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTA       TTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTT       TAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCCAAACCCACAACCACAGACATTGGCTCT       GATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTC       AAATATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCTGGCACCT       ACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGTGAACGGG       CCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGGAGTGTTT       CATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAGGTGGGGA       CCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCACCATCAAC       AATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGCCAGGCAC       AGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGGGCATCATAGCTGGGGCCACCATCGGCG       CGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTCTTCCTCTACCGGCGCCGCAAAGGCAGT       CGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCACTTACGAT       GCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCCATCTACT       CGTCGTTTATGGATGATGTGGATCTGAAGCAGGACCTGCGCTGCGACACCATCGACACCCGGGAGGAG       TATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGTCTTCCAG       GGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCATCCCGTC       TCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTATGGCCCT       GAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCTACGAGAA       CTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTGGGCTACC       CCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAGGCGTATGACCCCATTGGCAAGTACGCC       ACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGCGCATGCA       GACTCACGTG TAG   GGGCCAG                                                   NOV12n, CG51373-09   SEQ ID NO: 346   696 aa   MW at 76975.3kD               Protein Sequence                     MGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGP           VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV       FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILDYRWAKGGFLIE       DAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVG       NPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQ       YAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTH       YNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLD       IKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFMDDVDLKQDLRCDTIDTREEYEMKDPTNGY       YNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAP       AGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQ       HSDYGQRFQQRMQTNV                                             NOV12o, CG51373-12   SEQ ID NO: 347   2336 bp               DNA Sequence   ORF Start: ATG at 11   ORF Stop: at 2330                       CACCAAGCTT   ATG CTGAGCCTCCTCGTCTGGATCCTCACTCTCTCCGATACTTTCTCCCAAGGGACCC           AGACCCGCTTCAGCCAGGAGCCAGCTGACCAGACGGTGGTGGCTGGACAGCGGGCCGTGCTCCCCTGT       GTGCTGCTCAACTACTCTGGAATTGTGCAATGGACCAAGGACGGGCTGGCCCTGGGCATGGGCCAGGG       CCTCAAAGCCTGGCCACGGTACCGGGTTGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCA       CAGATGCTGAGCTCTCTGACGACGCCTCTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGG       CGGGCCAAACTCACCGTGCTCATCCCCCCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACT       GCAGGCAGGCACCCCCCACAACCTCACATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCT       GGTTCCGGGACGGGACGCAGCAGGAGGGCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGG       GAGACCACCGTGAGCCAACTGCTTATTAACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCG       AAGCATGAACGAAGCCATCCCTAGTGGCAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTA       CAGTGACCCTGTCCATTGAGCCACAGACGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCC       ACAGCCAACCCCGAGATCTTGGGCTACAGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGA       GAGTCGCTATGAGACAAATGTGGATTATTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACA       AAGTGGGAAGCACCAATGTCAGCACTTTAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCC       AAACCCACAACCACAGACATTGGCTCTGATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCT       CACTCTCACCTGGACCAAAAAGGACTCAAATATGGGGCCCAGGCCTCCTGGCTCCCCACCCGAGGCTG       CTCTCTCTGCCCAGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCT       GGCACCTACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGT       GAACGGGCCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGG       AGTGTTTCATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAG       GTGGGGACCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCAC       CATCAACAATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGC       CAGGCACAGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGGGCATCATAGCTGGGGCCACC       ATCGGCGCGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTCTTCCTCTACCGGCGCCGCAA       AGGCAGTCGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCAC       TTACGATGCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCC       ATCTACTCGTCGTTTAAGGATGATGTGGATCTGAAGCAGGACCTGCGCTGCGACACCATCGACACCCG       GGAGGAGTATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGT       CTTCCAGGGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCA       TCCCGTCTCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTA       TGGCCCTGAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCT       ACGAGAACTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTG       GGCTACCCCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAGGCGTATGACCCCATTGGCAA       GTACGCCACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGC       GCATGCAGACTCACGTGGTC GACG                                                   NOV12o, CG51373-12   SEQ ID NO: 348   773 aa   MW at 85048.5kD               Protein Sequence                     MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKA           WPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRHAKLTVLIPPEDTRIDGGPVILLQAG       TPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMN       EAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRY       ETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDTGSDVTLTCVWVGNPPLTLT       WTKKDSNMGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGP       PIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINN       VMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRPRKGSR       KDVTLRXLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEY       EMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPE       PTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYAT       ATRFSYTSQHSDYGQRFQQRMQTHV                                             NOV12p, CG51373-13   SEQ ID NO: 349   2290 bp               DNA Sequence   ORF Start: ATG at 11   ORF Stop: at 2282                       CACCAAGCTT   ATG CTGAGCCTCCTCGTCTGGATCCTCACTCTCTCCGATACTTTCTCCCAAGGGACCC           AGACCCGCTTCAGCCAGGAGCCAGCTGACCAGACGGTGGTGGCTGGACAGCGGGCCGTGCTCCCCTGT       GTGCTGCTCAACTACTCTGGAATTGTGCAATGGACCAAGGACGGGCTGGCCCTGGGCATGGGCCAGGG       CCTCAAAGCCTGGCCACGGTACCGGGTTGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCA       CAGATGCTGAGCTCTCTGACGACGCCTCTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGG       CGGGCCAAACTCACCGTGCTCATCCCCCCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACT       GCAGGCAGGCACCCCCCACAACCTCACATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCT       GGTTCCGGGACGGGACGCAGCAGGAGGGCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGG       GAGACCACCGTGAGCCAACTGCTTATTAACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCG       AAGCATGAACGAAGCCATCCCTAGTGGCAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTA       ACAGCCAACCCGGAGATCTTGGGCTACAGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGA       GAGTCGCTATGAGACAAATGTGGATTATTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTCCACAACA       AAGTGGGAAGCACCAATGTCAGCACTTTAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCC       AAACCCACAACCACAGACATTGGCTCTGATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCT       CACTCTCACCTGGACCAAAAAGGACTCAAATATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGT       CGGTGACTCAGGCAGACGCTGGCACCTACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAG       CGGGAGGTGCCGCTCTATGTGAACGGGCCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAG       GGGTGACGGTGGCAAGGTGGAGTGTTTCATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCT       GGAAGGAGAACTTCTTGGAGGTGGGGACCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGT       GGGGTGCTATCCACGCTCACCATCAACAATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCAC       CGCCTGGAACAGCTTCGGGCCAGGCACAGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGG       GCATCATAGCTGGGGCCACCATCGGCGCGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTC       TTCCTCTACCGGCGCCGCAAAGGCAGTCGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGA       GACAGTGAACCGAGAGCCACTTACGATGCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAG       CAACCCGGGTCATGAAGGCCATCTACTCGTCGTTTAAGGATGATGTGGATCTGAAGCAGGACCTGCGC       TGCGACACCATCGACACCCGGGAGGAGTATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCG       TGCCCATGAAGACCGCCCGTCTTCCAGGGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCC       GCTTCGACGGCCGCCCCTCATCCCGTCTCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGC       CGGGGCCCTGCCTCTGACTATGGCCCTGAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGA       CACAACCAGCCAGCTGTCCTACGAGAACTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTG       GGTACCCCACCTACCGACTGGGCTACCCCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAG       GCGTATGACCCCATTGGCAAGTACGCCACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTA       CGGCCAGCGATTCCAGCAGCGCATGCAGACTCACGTGGTCGACGGC                                                 NOV12p, CG51373-13   SEQ ID NO: 350   757 aa   MW at 83534.8kD               Protein Sequence                     MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKA           WPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAG       TPHNLTCRAFNAXPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMN       EAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRY       ETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLT       WTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDG       GKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWN       SFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVN       REPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHE       DRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTTS       QLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQR       FQQRMQTHV                                             NOV12q, CG51373-14   SEQ ID NO: 351   2290 bp               DNA Sequence   ORF Start: at 11   ORF Stop: at 2282                       CACCAAGCTT CAAGGGACCCAGACCCGCTTCAGCCAGGAGCCAGCTGACCAGACGGTGGTGGCTGGAC           AGCGGGCCGTGCTCCCCTGTGTGCTGCTCAACTACTCTGGAATTGTGCAATGGACCAAGGACGGGCTG       GCCCTGGGCATGGGCCAGGGCCTCAAAGCCTGGCCACGGTACCGGGTTGTGGGCTCCGCAGACGCTGG       GCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCTCTTACGAGTGCCAGGCCACGG       AGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCCCCAGAGGACACCAGGATTGAC       GGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCACATGCCGGGCCTTCAATGCGAA       GCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGGGCGCTGTGGCCAGCACGGAAT       TGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATTAACCCCACGGACCTGGACATA       GGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGGCAAGGAGACTTCCATCGAGCT       GGATGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGACGGTGCAGGAGGGTGAGCGTG       TTGTCTTTACCTGCCAGGCCACAGCCAACCCGGAGATCTTGGGCTACAGGTGGGCCAAAGGGGGTTTC       TTGATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTATTCCTTTTTCACGGAGCCTGT       GTCTTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTTTAGTAAATGTCCACTTTGCTC       CCCGGATTGTAGTTGACCCCAAACCCACAACCACAGACATTGGCTCTGATGTGACCCTTACCTGTGTC       TGGGTTGGGAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTCAAATATGGGGCCCAGGCCTCC       TGGCTCCCCACCCGAGGCTGCTCTCTCTGCCCAGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGT       CGGTGACTCAGGCAGACGCTGGCACCTACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAG       CGGGAGGTGCCGCTCTATGTGAACGGGCCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAG       GGGTGACGGTGGCAAGGTGGAGTGTTTCATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCT       GGAAGGAGAACTTCTTGGAGGTGGGGACCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGT       GGGGTGCTATCCACGCTCACCATCAACAATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCAC       CGCCTGGAACAGCTTCGGGCCAGGCACAGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGG       GCATCATAGCTGGGGCCACCATCGGCGCGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTC       TTCCTCTACCGGCGCCGCAAAGGCAGTCGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGA       GACAGTGAACCGAGAGCCACTTACGATGCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAG       CAACCCGGGTCATGAAGGCCATCTACTCGTCGTTTAAGGATGATGTGGATCTGAAGCAGGACCTGCGC       TGCGACACCATCGACACCCGGGAGGAGTATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCG       TGCCCATGAAGACCGCCCGTCTTCCAGGGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCC       GCTTCGACGGCCGCCCCTCATCCCGTCTCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGC       CGGGGCCCTGCCTCTGACTATGGCCCTGAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGA       CACAACCAGCCAGCTGTCCTACGAGAACTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTG       GGTACCCCACCTACCGACTGGGCTACCCCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAG       GCGTATGACCCCATTGGCAAGTACGCCACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTA       CGGCCAGCGATTCCAGCAGCGCATGCAGACTCACGTGGTC GACGGC                                                   NOV12q, CG51373-14   SEQ ID NO: 352   757 aa   MW at 83227.3kD               Protein Sequence                     QGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYN           LEITDAELSDDASYECQATEAALRSRPAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAA       TIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVH       HPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCE       VHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSP       PEAALSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDG       GKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWN       SFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVN       REPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHE       DRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTTS       QLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQR       FQQRMQTHV                                     NOV12r, SNP13377352 of   SEQ ID NO: 353   2128 bp           CG51373-08, DNA Sequence   ORF Start: ATG at 31   ORF Stop: TAG at 2119           SNP Pos: 487   SNP Change: T to C                       CAATGGACCAAGGACGGGCTGGCCCTGGGC   ATG GGCCAGGGCCTCAAAGCCTGGCCACGGTACCGGGT           TGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCT       CTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCC       CCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCAC       ATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGG       GCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATT       AACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGG       CAAGGAGACTCCCATCGAGCTGGATGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGA       CGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCCACAGCCAACCCCGAGATCTTGGACTAC       AGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTA       TTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTT       GATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTC       AAATATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCTGGCACCT       ACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGTGAACGGG       CCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGGAGTGTTT       CATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAGGTGGGGA       CCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCACCATCAAC       AATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGCCAGGCAC       AGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGGGCATCATAGCTGGGGCCACCATCGGCG       CGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTCTTCCTCTACCGGCGCCGCAAAGGCAGT       CGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCACTTACGAT       GCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCCATCTACT       CGTCGTTTATGGATGATGTGGATCTGAAGCAGGACCTGCGCTGCGACACCATCGACACCCGGGAGGAG       TATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGTCTTCCAG       GGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCATCCCGTC       TCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTATGGCCCT       GAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCTACGAGAA       CTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTGGGCTACC       CCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAGGCGTATGACCCCATTGGCAAGTACGCC       ACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGCGCATGCA       GACTCACGTG TAG   GGGCCAG                                           NOV12r, SNP13377352 of   SEQ ID NO: 354   696 aa   MW at 76985.3kD           CG51373-08, Protein   SNP Pos: 153       SNP Change: Ser to Pro       Sequence                     MGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGP           VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV       FTCRSMNEAIPSGKET   P   IELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILDYRWAKGGFLIE       DAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVG       NPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQ       YAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTH       YNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLD       IKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFMDDVDLKQDLRCDTIDTREEYEMKDPTNGY       YNVRAHEDRPSSRAVLYADYEAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAP       AGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQ       HSDYGQRFQQRMQTHV                                     NOV12s, SNP13379746 of   SEQ ID NO: 355   2128 bp           CG51373-08, DNA Sequence   ORF Start: ATG at 31   ORF Stop: TAG at 2119           SNP Pos: 597   SNP Change: C to G                       CAATGGACCAAGGACGGGCTGGCCCTGGGC   ATG GGCCAGGGCCTCAAAGCCTGGCCACGGTACCGGGT           TGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCT       CTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCC       CCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCAC       ATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGG       GCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATT       AACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGG       CAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGA       CGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCCACAGCCAACCC   G   GAGATCTTGGACTAC       AGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTA       TTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTT       TAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCCAAACCCACAACCACAGACATTGGCTCT       GATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTC       AAATATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCTGGCACCT       ACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGTGAACGGG       CCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGGAGTGTTT       CATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAGGTGGGGA       CCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCACCATCAAC       AATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGCCAGGCAC       AGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGGGCATCATAGCTGGGGCCACCATCGGCG       CGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTCTTCCTCTACCGGCGCCGCAAAGGCAGT       CGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCACTTACGAT       GCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCCATCTACT       CGTCGTTTATGGATGATGTGGATCTGAAGCAGGACCTGCGCTGCGACACCATCGACACCCGGGAGGAG       TATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGTCTTCCAG       GGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCATCCCGTC       TCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTATGGCCCT       GAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCTACGAGAA       CTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTGGGCTACC       CCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAGGCGTATGACCCCATTGGCAAGTACGCC       ACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGCGCATGCA       GACTCACGTG TAG   GGGCCAG                                           NOV12s, SNP13379746 of   SEQ ID NO: 356   696 aa   MW at 76975.3kD           CG51373-08, Protein   SNP Pos: 189       SNP Change: Pro to Pro       Sequence                     MGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGP           VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV       FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATAN   P   EILDYRWAKGGFLIE       DAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVG       NPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQ       YAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTH       YNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLD       IKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFMDDVDLKQDLRCDTIDTREEYEMKDPTNGY       YNVRAHEDRPSSRAVLYADYEAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAP       AGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQ       HSDYGQRFQQRMQTHV                                     NOV12t, SNP13374859 of   SEQ ID NO: 357   2128 bp           CG51373-08, DNA Sequence   ORF Start: ATG at 31   ORF Stop: TAG at 2119           SNP Pos: 961   SNP Change: C to T                       CAATGGACCAAGGACGGGCTGGCCCTGGGC   ATG GGCCAGGGCCTCAAAGCCTGGCCACGGTACCGGGT           TGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCT       CTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCC       CCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCAC       ATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGG       GCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATT       AACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGG       CAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGA       CGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCCACAGCCAACCCCGAGATCTTGGACTAC       AGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTA       TTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTT       TAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCCAAACCCACAACCACAGACATTGGCTCT       GATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTC       AAATATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCTGGCACCT       ACACCTGC   T   GGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGTGAACGGG       CCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGGAGTGTTT       CATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAGGTGGGGA       CCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCACCATCAAC       AATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGCCAGGCAC       AGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGGGCATCATAGCTGGGGCCACCATCGGCG       CGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTCTTCCTCTACCGGCGCCGCAAAGGCAGT       CGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCACTTACGAT       GCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCCATCTACT       CGTCGTTTATGGATGATGTGGATCTGAAGCAGGACCTGCGCTGCGACACCATCGACACCCGGGAGGAG       TATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGTCTTCCAG       GGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCATCCCGTC       TCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTATGGCCCT       GAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCTACGAGAA       CTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTGGGCTACC       CCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAGGCGTATGACCCCATTGGCAAGTACGCC       ACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGCGCATGCA       GACTCACGTG TAG   GGGCCAG                                           NOV12t, SNP13374859 of   SEQ ID NO: 358   696 aa   MW at 77005.3kD           CG51373-08, Protein   SNP Pos: 311       SNP Change: Arg to Trp       Sequence                     MGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGP           VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV       FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILDYRWAKGGFLIE       DAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVG       NPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTC   W   AIVPRIGVAEREVPLYVNGPPIISSEAVQ       YAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTH       YNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLD       IKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFMDDVDLKQDLRCDTIDTREEYEMKDPTNGY       YNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAP       AGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQ       HSDYGQRFQQRMQTHV                                     NOV12u, SNP13374858 of   SEQ ID NO: 359   2128 bp           CG51373-08, DNA Sequence   ORF Start: ATG at 31   ORF Stop: TAG at 2119           SNP Pos: 1340   SNP Change: T to C                       CAATGGACCAAGGACGGGCTGGCCCTGGGC   ATG GGCCAGGGCCTCAAAGCCTGGCCACGGTACCGGGT           TGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCT       CTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCC       CCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCAC       ATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGG       GCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATT       AACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGG       CAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGA       CGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCCACAGCCAACCCCGAGATCTTGGACTAC       AGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTA       TTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTT       TAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCCAAACCCACAACCACAGACATTGGCTCT       GATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTC       AAATATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCTGGCACCT       ACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGTGAACGGG       CCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGGAGTGTTT       CATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAGGTGGGGA       CCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCACCATCAAC       AATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGCCAGGCAC       AGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGGGCATCA   C   AGCTGGGGCCACCATCGGCG       CGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTCTTCCTCTACCGGCGCCGCAAAGGCAGT       CGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCACTTACGAT       GCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCCATCTACT       CGTCGTTTATGGATGATGTGGATCTGAAGCAGGACCTGCGCTGCGACACCATCGACACCCGGGAGGAG       TATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGTCTTCCAG       GGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCATCCCGTC       TCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTATGGCCCT       GAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCTACGAGAA       CTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTGGGCTACC       CCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAGGCGTATGACCCCATTGGCAAGTACGCC       ACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGCGCATGCA       GACTCACGTG TAG   GGGCCAG                                           NOV12u, SNP13374858 of   SEQ ID NO: 360   696 aa   MW at 76963.2kD           CG51373-08, Protein   SNP Pos: 437       SNP Change: Ile to Thr       Sequence                     MGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGP           VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV       FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILDYRWAKGGFLIE       DAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVG       NPPLTLTWTKKDSNNVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQ       YAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTH       YNCTAWNSFGPGTAIIQLEEREVLPVGI   T   AGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLD       IKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFMDDVDLKQDLRCDTIDTREEYEMKDPTNGY       YNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAP       AGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQ       HSDYGQRFQQRMQTHV                                     NOV12v, SNP13374856 of   SEQ ID NO: 361   2128 bp           CG51373-08, DNA Sequence   ORF Start: ATG at 31   ORF Stop: TAG at 2119           SNP Pos: 1418   SNP Change: G to A                       CAATGGACCAAGGACGGGCTGGCCCTGGGC   ATG GGCCAGGGCCTCAAAGCCTGGCCACGGTACCGGGT           TGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCT       CTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCC       CCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCAC       ATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGG       GCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGACGGAGACCACCGTGAGCCAACTGCTTATT       AACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGG       CAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGA       CGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCCACAGCCAACCCCGAGATCTTGGACTAC       AGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTA       TTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTT       TAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCCAAACCCACAACCACAGACATTGGCTCT       GATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTC       AAATATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCTGGCACCT       ACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGTGAACGGG       CCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGGAGTGTTT       CATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAGGTGGGGA       CCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCACCATCAAC       AATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGCCAGGCAC       AGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGGGCATCATAGCTGGGGCCACCATCGGCG       CGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTCTTCCTCTACCGGCGCC   A   CAAAGGCAGT       CGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCACTTACGAT       GCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCCATCTACT       CGTCGTTTATGGATGATGTGGATCTGAAGCAGGACCTGCGCTGCGACACCATCGACACCCGGGAGGAG       TATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGTCTTCCAG       GGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCATCCCGTC       TCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTATGGCCCT       GAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCTACGAGAA       CTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTGGGCTACC       CCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAGGCGTATGACCCCATTGGCAAGTACGCC       ACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGCGCATGCA       GACTCACGTG TAG   GGGCCAG                                           NOV12v, SNP13374856 of   SEQ ID NO: 362   696 aa   MW at 76956.2kD           CG51373-08, Protein   SNP Pos: 463       SNP Change: Arg to His       Sequence                     MGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRPAKLTVLIPPEDTRIDGGP           VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV       FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILDYRWAKGGFLIE       DAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVG       NPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCEAIVPRIGVAEREVPLYVNGPPIISSEAVQ       YAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTH       YNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRR   H   KGSRKDVTLRKLD       IKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFMDDVDLKQDLRCDTIDTREEYEMKDPTNGY       YNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAP       AGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQ       HSDYGQRFQQRMQTHV                                     NOV12w, SNP13374855 of   SEQ ID NO: 363   2128 bp           CG51373-08, DNA Sequence   ORF Start: ATG at 31   ORF Stop: TAG at 2119           SNP Pos: 1421   SNP Change: A to G                       CAATGGACCAAGGACGGGCTGGCCCTGGGC   ATG GGCCAGGGCCTCAAAGCCTGGCCACGGTACCGGGT           TGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCT       CTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCC       CCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCAC       ATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGG       GCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATT       AACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGG       CAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGA       CGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCCACAGCCAACCCCGAGATCTTGGACTAC       AGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTA       TTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTT       TAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCCAAACCCACAACCACAGACATTGGCTCT       GATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTC       AAATATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCTGGCACCT       ACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGTGAACGGG       CCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGGAGTGTTT       CATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAGGTGGGGA       CCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCACCATCAAC       AATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGCCAGGCAC       AGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGGGCATCATAGCTGGGGCCACCATCGGCG       CGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTCTTCCTCTACCGGCGCCGCA   G   AGGCAGT       CGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCACTTACGAT       GCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCCATCTACT       CGTCGTTTATGGATGATGTGGATCTGAAGCAGGACCTGCGCTGCGACACCATCGACACCCGGGAGGAG       TATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGTCTTCCAG       GGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCATCCCGTC       TCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTATGGCCCT       GAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCTACGAGAA       CTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTGGGCTACC       CCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAGGCGTATGACCCCATTGGCAAGTACGCC       ACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGCGCATGCA       GACTCACGTG TAG   GGGCCAG                                           NOV12w, SNP13374855 of   SEQ ID NO: 364   696 aa   MW at 77003.3kD           CG51373-08, Protein   SNP Pos: 464       SNP Change: Lys to Arg       Sequence                     MGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGP           VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV       FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILDYRWAKGGFLIE       DAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVG       NPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQ       YAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTH       YNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRR   R   GSRKDVTLRKLD       IKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFMDDVDLKQDLRCDTIDTREEYEMKDPTNGY       YNVRAEEDRPSSEAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAP       AGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQ       HSDYGQRFQQRMQTHVJ                                     NOV12x, SNP13374854 of   SEQ ID NO: 365   2128 bp           CG51373-08, DNA Sequence   ORF Start: ATG at 31   ORF Stop: TAG at 2119           SNP Pos: 1426   SNP Change: A to T                       CAATGGACCAAGGACGGGCTGGCCCTGGGC   ATG GGCCAGGGCCTCAAAGCCTGGCCACGGTACCGGGT           TGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCT       CTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCC       CCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCAC       ATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGG       GCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATT       AACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGG       CAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGA       CGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCCACAGCCAACCCCGAGATCTTGGACTAC       AGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTA       TTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTT       TAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCCAAACCCACAACCACAGACATTGGCTCT       GATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTC       AAATATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCTGGCACCT       ACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGTGAACGGG       CCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGGAGTGTTT       CATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAGGTGGGGA       CCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCACCATCAAC       AATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGCCAGGCAC       AGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGGGCATCATAGCTGGGGCCACCATCGGCG       CGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTCTTCCTCTACCGGCGCCGCAAAGGC   T   GT       CGCAAAGACGTGACCCTGAGGAAGCTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCACTTACGAT       GCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCCATCTACT       CGTCGTTTATGGATGATGTGGATCTGAAGCAGGACCTGCGCTGCGACACCATCGACACCCGGGAGGAG       TATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGTCTTCCAG       GGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCATCCCGTC       TCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTATGGCCCT       GAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCTACGAGAA       CTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTGGGCTACC       CCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAGGCGTATGACCCCATTGGCAAGTACGCC       ACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGCGCATGCA       GACTCACGTG TAG   GGGCCAG                                           NOV12x, SNP13374854 of   SEQ ID NO: 366   696 aa   MW at 76991.4kD           CG51373-08, Protein   SNP Pos: 466       SNP Change: Ser to Cys       Sequence                     MGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGP           VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV       FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILDYRWAKGGFLIE       DAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVG       NPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQ       YAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTH       YNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKG   C   RKDVTLRKLD       IKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFMDDVDLKQDLRCDTIDTREEYEMKDPTNGY       YNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAP       AGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQ       HSDYGQRFQQRMQTHV                                     NOV12y, SNP13374853 of   SEQ ID NO: 367   2128 bp           CG51373-08, DNA Sequence   ORF Start: ATG at 31   ORF Stop: TAG at 2119           SNP Pos: 1436   SNP Change: A to G                       CAATGGACCAAGGACGGGCTGGCCCTGGGC   ATG GGCCAGGGCCTCAAAGCCTGGCCACGGTACCGGGT           TGTGGGCTCCGCAGACGCTGGGCAGTACAACCTGGAGATCACAGATGCTGAGCTCTCTGACGACGCCT       CTTACGAGTGCCAGGCCACGGAGGCCGCCCTGCGCTCTCGGCGGGCCAAACTCACCGTGCTCATCCCC       CCAGAGGACACCAGGATTGACGGAGGCCCTGTGATTCTACTGCAGGCAGGCACCCCCCACAACCTCAC       ATGCCGGGCCTTCAATGCGAAGCCTGCTGCCACCATCATCTGGTTCCGGGACGGGACGCAGCAGGAGG       GCGCTGTGGCCAGCACGGAATTGCTGAAGGATGGGAAGAGGGAGACCACCGTGAGCCAACTGCTTATT       AACCCCACGGACCTGGACATAGGGCGTGTCTTCACTTGCCGAAGCATGAACGAAGCCATCCCTAGTGG       CAAGGAGACTTCCATCGAGCTGGATGTGCACCACCCTCCTACAGTGACCCTGTCCATTGAGCCACAGA       CGGTGCAGGAGGGTGAGCGTGTTGTCTTTACCTGCCAGGCCACAGCCAACCCCGAGATCTTGGACTAC       AGGTGGGCCAAAGGGGGTTTCTTGATTGAAGACGCCCACGAGAGTCGCTATGAGACAAATGTGGATTA       TTCCTTTTTCACGGAGCCTGTGTCTTGTGAGGTTCACAACAAAGTGGGAAGCACCAATGTCAGCACTT       TAGTAAATGTCCACTTTGCTCCCCGGATTGTAGTTGACCCCAAACCCACAACCACAGACATTGGCTCT       GATGTGACCCTTACCTGTGTCTGGGTTGGGAATCCCCCCCTCACTCTCACCTGGACCAAAAAGGACTC       AAATATGGTCCTGAGTAACAGCAACCAGCTGCTGCTGAAGTCGGTGACTCAGGCAGACGCTGGCACCT       ACACCTGCCGGGCCATCGTGCCTCGAATCGGAGTGGCTGAGCGGGAGGTGCCGCTCTATGTGAACGGG       CCCCCCATCATCTCCAGTGAGGCAGTGCAGTATGCTGTGAGGGGTGACGGTGGCAAGGTGGAGTGTTT       CATTGGGAGCACACCACCCCCAGACCGCATAGCATGGGCCTGGAAGGAGAACTTCTTGGAGGTGGGGA       CCCTGGAACGCTATACAGTGGAGAGGACCAACTCAGGCAGTGGGGTGCTATCCACGCTCACCATCAAC       AATGTCATGGAGGCCGACTTTCAGACTCACTACAACTGCACCGCCTGGAACAGCTTCGGGCCAGGCAC       AGCCATCATCCAGCTGGAAGAGCGAGAGGTGTTACCTGTGGGCATCATAGCTGGGGCCACCATCGGCG       CGAGCATCCTGCTCATCTTCTTCTTCATCGCCTTGGTATTCTTCCTCTACCGGCGCCGCAAAGGCAGT       CGCAAAG   G   CGTGACCCTGAGGAAGCTGGATATCAAGGTGGAGACAGTGAACCGAGAGCCACTTACGAT       GCATTCTGACCGGGAGGATGACACCGCCAGCGTCTCCACAGCAACCCGGGTCATGAAGGCCATCTACT       CGTCGTTTATGGATGATGTGGATCTGAAGCAGGACCTGCGCTGCGACACCATCGACACCCGGGAGGAG       TATGAGATGAAGGACCCCACCAATGGCTACTACAACGTGCGTGCCCATGAAGACCGCCCGTCTTCCAG       GGCAGTGCTCTATGCTGACTACCGTGCCCCTGGCCCTGCCCGCTTCGACGGCCGCCCCTCATCCCGTC       TCTCCCACTCCAGCGGCTATGCCCAGCTCAACACCTATAGCCGGGGCCCTGCCTCTGACTATGGCCCT       GAGCCCACACCCCCTGGCCCTGCTGCCCCAGCTGGCACTGACACAACCAGCCAGCTGTCCTACGAGAA       CTATGAGAAGTTCAACTCCCATCCCTTCCCTGGGGCAGCTGGGTACCCCACCTACCGACTGGGCTACC       CCCAGGCCCCACCCTCTGGCCTGGAGCGGACCCCATATGAGGCGTATGACCCCATTGGCAAGTACGCC       ACAGCCACTCGATTCTCCTACACCTCCCAGCACTCGGACTACGGCCAGCGATTCCAGCAGCGCATGCA       GACTCACGTG TAG   GGGCCAG                                           NOV12y, SNP13374853 of   SEQ ID NO: 368   696 aa   MW at 76917.3kD           CG51373-08, Protein   SNP Pos: 469       SNP Change: Asp to Gly       Sequence                     MGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGP           VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV       FTCRSNNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILDYRWAKGGFLIE       DAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVG       NPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQ       YAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTH       YNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRK   G   VTLRKLD       IKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFMDDVDLKQDLRCDTIDTREEYEMKDPTNGY       YNVEAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAP       AGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQ       HSDYGQRFQQRMQTHV                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 12B.  
               TABLE 12B                       Comparison of the NOV12 protein sequences.                                        NOV12a ------------------------------------------------------------           NOV12b ------------------------------------------------------------       NOV12c ------------------------------------------------------------       NOV12d ------------------------------------------------------------       NOV12e ------------------------------------------------------------       NOV12f ------------------------------------------------------------       NOV12g MHLTLEVLNHGPFPLNLSSIAYNHGTVFGHWKNNVTRETLVKVKDAEDQLGARVGYIELD       NOV12h MHLTLEVLNHGPFPLNLSSIAYNHGTVFGHWKNNVTRETLVKVKDAEDQLGARVGYIELD       NOV12i ------------------------------------------------------------       NOV12j ------------------------------------------------------------       NOV12k ------------------------------------------------------------       NOV12l ------------------------------------------------------------       NOV12m ------------------------------------------------------------       NOV12n ------------------------------------------------------------       NOV12o ------------------------------------------------------------       NOV12p ------------------------------------------------------------       NOV12q ------------------------------------------------------------               NOV12a -------------------------MLSLLVWILTLSDTFSQGTQTRFSQEPADQWVAGQ       NOV12b ------------------------------------------------------------       NOV12c ------------------------------------------------------------       NOV12d ------------------------------------------------------------       NOV12e ---------------------TKLMLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQ       NOV12f ---------------------TKLMLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQ       NOV12g LNSGKETFLVNEEATGETSGDNVVBSRNLSQTIFITRKRWEGTQTRFSQEPADQTVVAGQ       NOV12h LNSGKETFLVNEEATGETSGDNVVHSRNLSQTIFITRKRWEGTQTRFSQEPADQTVVAGQ       NOV12i ------------------------------------------------------------       NOV12j ------------------------------------------------------------       NOV12k ------------------------------------------------------------       NOV12l ------------------------------------------------------------       NOV12m ---------------------------------------------RFSQEPADQTVVAGQ       NOV12n ------------------------------------------------------------       NOV12o ------------------------MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQ       NOV12p ------------------------MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQ       NOV12q ----------------------------------------QGTQTRFSQEPADQTVVAGQ               NOV12a RAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12b -------------------------MGQALKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12c -------------------------MGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12d -----------------------GSMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12e RAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12f RAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12g RAVLPCVLLNYSGIVQWTKDGLALGMGQALKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12h RAVLPCVLLNYSGIVQWTKDGLALGMGQALKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12i -------------------------MGQALKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12j -------------------------MGQALKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12k -------------------------MGQALKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12l -------------------------MGQALKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12m RAVLPCVLLNYSGIVQWTKDGLALGMGQALKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12n -------------------------MGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12o RAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12p RAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDA       NOV12q RAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDA               NOV12a SYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIW       NOV12b SYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIW       NOV12c SYECQATEAALRSRRAXLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIW       NOV12d SYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCEAFNAKPAATIIW       NOV12e SYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCEAFNAKPAATIIW       NOV12f SYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIW       NOV12g SYECQATEAALRSRRAXLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIW       NOV12h SYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCEAFNAKPAATIIW       NOV12i SYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIW       NOV12j SYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIW       NOV12k SYECQATEAALRSRPAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIW       NOV12l SYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIW       NOV12m SYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIW       NOV12n SYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIW       NOV12o SYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIW       NOV12p SYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCHAFNAKPAATIIW       NOV12q SYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIW               NOV12a FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE       NOV12b FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE       NOV12c FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE       NOV12d FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE       NOV12e FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE       NOV12f FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE       NOV12g FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE       NOV12h FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE       NOV12i FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE       NOV12j FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE       NOV12k FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE       NOV12l FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE       NOV12m FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE       NOV12n FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSNNEAIPSGKETSIE       NOV12o FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE       NOV12p FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE       NOV12q FRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE               NOV12a LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNV       NOV12b LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNV       NOV12c LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILDYRWAKGGFLIEDAHESRYETNV       NOV12d LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILDYRWAKGGFLIEDAHESRYETNV       NOV12e LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNV       NOV12f LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNV       NOV12g LDVHREWAGGSSLEQGGGRRGVFEKHTLSLRNTN--------------------------       NOV12h LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNV       NOV12i LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNV       NOV12j LDVHREWAGGSSLEQGGGRRGVFEKHTLSLRNTN--------------------------       NOV12k LDVHREWAGGSSLEQGGGRRGVFEKHTLSLRNTN--------------------------       NOV12l LDVHREWAGGSSLEQGGGRRGVFEKHTLSLRNTN--------------------------       NOV12m LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNV       NOV12n LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILDYRWAKGGFLIEDAHESRYETNV       NOV12o LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNV       NOV12p LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNV       NOV12q LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNV               NOV12a DYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPP       NOV12b DYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGEIP       NOV12c DYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPP       NOV12d DYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPP       NOV12e DYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPP       NOV12f DYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPP       NOV12g ------------------------------------------------------------       NOV12h DYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPP       NOV12i DYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPP       NOV12j ------------------------------------------------------------       NOV12k ------------------------------------------------------------       NOV12l ------------------------------------------------------------       NOV12m DYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPP       NOV12n DYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPP       NOV12o DYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPP       NOV12p DYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPP       NOV12q DYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPP               NOV12a LTLTWTKKD-----------------SNMVLSNSNQLLLKSVTQADAGTYTCPAIVPRIG       NOV12b PSLSPGPKRTQILGPWLLGSPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIG       NOV12c LTLTWTKKD-----------------SNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIG       NOV12d LTLTWTKKD-----------------SNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIG       NOV12e LTLTWTKKD-----------------SNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIG       NOV12f LTLTWTKKDSN-MGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCPAIVPRIG       NOV12g ------------------------------------------------------------       NOV12h LTLTWTKKD-----------------SNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIG       NOV12i LTLTWTKK-----------------DSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIG       NOV12j ------------------------------------------------------------       NOV12k ------------------------------------------------------------       NOV12l ------------------------------------------------------------       NOV12m LTLTWTKKD-----------------SNMVLSNSNQLLLKSVTQADAGTYTCRATVPRIG       NOV12n LTLTWTKKD-----------------SNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIG       NOV12o LTLTWTKKDSN-MGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIG       NOV12p LTLTWTKKD-----------------SNMVLSNSNQLLLKSVTQADAGTYTCEAIVPRIG       NOV12q LTLTWTKKDSN-MGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIG               NOV12a VAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLE       NOV12b VAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLE       NOV12c VAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLE       NOV12d VAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLE       NOV12e VAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLE       NOV12f VAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLE       NOV12g ------------------------------------------------------------       NOV12h VAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLE       NOV12i VAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLE       NOV12j ------------------------------------------------------------       NOV12k ------------------------------------------------------------       NOV12l ------------------------------------------------------------       NOV12m VAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLE       NOV12n VAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLE       NOV12o VAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLE       NOV12p VAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLE       NOV12q VAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLE               NOV12a RYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIA       NOV12b RYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIA       NOV12c RYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIA       NOV12d RYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIA       NOV12e RYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIA       NOV12f RYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIA       NOV12g ------------------------------------------------------------       NOV12h RYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIA       NOV12i RYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIA       NOV12j ------------------------------------------------------------       NOV12k ------------------------------------------------------------       NOV12l ------------------------------------------------------------       NOV12m RYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEER---------       NOV12n RYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIA       NOV12o RYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIA       NOV12p RYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIA       NOV12q RYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIA               NOV12a GATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTA       NOV12b GATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTA       NOV12c GATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTA       NOV12d GATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTA       NOV12e GATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTA       NOV12f GATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTA       NOV12g ------------------------------------------------------------       NOV12h GATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTA       NOV12i GATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTA       NOV12j ------------------------------------------------------------       NOV12k ------------------------------------------------------------       NOV12l ------------------------------------------------------------       NOV12m ------------------------------------------------------------       NOV12n GATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTA       NOV12o GATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTA       NOV12p GATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTA       NOV12q GATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTA               NOV12a SVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRA       NOV12b SVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVPAHEDRPSSRA       NOV12c SVSTATRVMKAIYSSFMDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRA       NOV12d SVSTATRVMKAIYSSFMDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSEA       NOV12e SVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSEA       NOV12f SVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRA       NOV12g ------------------------------------------------------------       NOV12h SVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRA       NOV12i SVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRA       NOV12j ------------------------------------------------------------       NOV12k ------------------------------------------------------------       NOV12l ------------------------------------------------------------       NOV12m ------------------------------------------------------------       NOV12n SVSTATRVMKAIYSSFMDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRA       NOV12o SVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRA       NOV12p SVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRA       NOV12q SVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRA               NOV12a VLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTT       NOV12b VLYADYPAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTT       NOV12c VLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTT       NOV12d VLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTT       NOV12e VLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYQPEPTPPGPAAPAGTDTT       NOV12f VLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTT       NOV12g ------------------------------------------------------------       NOV12h VLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTT       NOV12i VLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTT       NOV12j ------------------------------------------------------------       NOV12k ------------------------------------------------------------       NOV12l ------------------------------------------------------------       NOV12m ------------------------------------------------------------       NOV12n VLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTT       NOV12o VLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTT       NOV12p VLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTT       NOV12q VLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTT               NOV12a SQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYT       NOV12b SQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYT       NOV12c SQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYT       NOV12d SQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYT       NOV12e SQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYT       NOV12f SQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYT       NOV12g ------------------------------------------------------------       NOV12h SQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYT       NOV12i SQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYT       NOV12j ------------------------------------------------------------       NOV12k ------------------------------------------------------------       NOV12l ------------------------------------------------------------       NOV12m ------------------------------------------------------------       NOV12n SQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYT       NOV12o SQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYT       NOV12p SQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYT       NOV12q SQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYT               NOV12a SQHSDYGQRFQQRMQTHV---       NOV12b SQHSDYGQRFQQRMQTHV---       NOV12c SQHSDYGQRFQQRMQTHV---       NOV12d SQHSDYGQRFQQRMQTHVLE-       NOV12e SQHSDYGQRFQQRMQTHVVDG       NOV12f SQHSDYGQRFQQRMQTHVVD-       NOV12g ---------------------       NOV12h SQHSDYGQRFQQRMQTHV---       NOV12i SQHSDYGQRFQQRMQTHV---       NOV12j ---------------------       NOV12k ---------------------       NOV12l ---------------------       NOV12m ---------------------       NOV12n SQHSDYGQRFQQRMQTHV---       NOV12o SQHSDYGQRFQQRMQTHV---       NOV12p SQHSDYGQRFQQRMQTHV---       NOV12q SQHSDYGQRFQQRMQTHV---               NOV12a (SEQ ID NO: 320)       NOV12b (SEQ ID NO: 322)       NOV12c (SEQ ID NO: 324)       NOV12d (SEQ ID NO: 326)       NOV12e (SEQ ID NO: 328)       NOV12f (SEQ ID NO: 330)       NOV12g (SEQ ID NO: 332)       NOV12h (SEQ ID NO: 334)       NOV12i (SEQ ID NO: 336)       NOV12j (SEQ ID NO: 338)       NOV12k (SEQ ID NO: 340)       NOV12l (SEQ ID NO: 342)       NOV12m (SEQ ID NO: 344)       NOV12n (SEQ ID NO: 346)       NOV12o (SEQ ID NO: 348)       NOV12p (SEQ ID NO: 350)       NOV12q (SEQ ID NO: 352)                  
 
      Further analysis of the NOV12a protein yielded the following properties shown in Table 12C.  
               TABLE 12C                       Protein Sequence Properties NOV12a                                        SignalP analysis:   Cleavage site between residues 17 and 18       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 0; pos. chg 0; neg. chg 0           H-region:   length 12; peak value 10.45           PSG score:   6.05                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 0.73           possible cleavage site: between 16 and 17                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 16)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 17           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 503-519               −12.26                             PERIPHERAL   Likelihood = 3.61 (at 38)                         ALOM score: −12.26 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 8           Charge difference: −2.0 C(−1.0)-N(1.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 1a (cytoplasmic tail 520 to 757)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   1   Hyd Moment(75):   1.68           Hyd Moment(95):   2.60   G content:   1           D/E content:   2   S/T content:   8                         Score: −5.22       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 32 TRF|SQ                 NUCDISC: discrimination of nuclear localization signals                         pat4: RRRK (5) at 522           pat7: none           bipartite: none           content of basic residues: 9.6%           NLS Score: −0.16       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 70.6       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         44.4%: endoplasmic reticulum           22.2%: Golgi           22.2%: extracellular, including cell wall           11.1%: plasma membrane                 &gt;&gt; prediction for CG51373-11 is end (k = 9)                  
 
      A search of the NOV12a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 12D.  
               TABLE 12D                          Geneseq Results for NOV12a                                         NOV12a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               ABB05749   Human G protein-coupled receptor   17 . . . 757   739/741 (99%)   0.0           NOV1a protein SEQ ID NO: 2 -  Homo     101 . . . 841    740/741 (99%)             sapiens , 841 aa. [WO200200691-A2,           03-JAN-2002]       ABP66884   Human polypeptide SEQ ID NO 605 -   57 . . . 757   701/717 (97%)   0.0             Homo sapiens , 749 aa.   33 . . . 749   701/717 (97%)           [US2002090672-A1, 11-JUL-2002]       ABB10297   Human cDNA SEQ ID NO: 605 -  Homo     57 . . . 757   701/717 (97%)   0.0             sapiens , 749 aa. [WO200154474-A2,   33 . . . 749   701/717 (97%)           02-AUG-2001]       ABB05762   Human G protein-coupled receptor   62 . . . 757   695/696 (99%)   0.0           NOV7b protein SEQ ID NO: 26 -  Homo      1 . . . 696   695/696 (99%)             sapiens , 696 aa. [WO200200691-A2,           03-JAN-2002]       ABG65107   Human albumin fusion protein #1782 -   62 . . . 757   696/712 (97%)   0.0             Homo sapiens , 712 aa. [WO200177137-    1 . . . 712   696/712 (97%)           A1, 18-OCT-2001]                  
 
      In a BLAST search of public sequence databases, the NOV12a protein was found to have homology to the proteins shown in the BLASTP data in Table 12E.  
               TABLE 12E                          Public BLASTP Results for NOV12a                                         NOV12a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               CAD23338   Sequence 1 from Patent   17 . . . 757   739/741 (99%)   0.0           WO0200691 -  Homo sapiens     101 . . . 841    740/741 (99%)           (Human), 841 aa.       AAO91769   NEPH1 -  Mus musculus  (Mouse),   18 . . . 757   717/740 (96%)   0.0           789 aa.   50 . . . 789   728/740 (97%)       Q8CJ59   NEPH1 -  Mus musculus  (Mouse),   18 . . . 757   714/740 (96%)   0.0           789 aa.   50 . . . 789   726/740 (97%)       CAD23349   Sequence 25 from Patent   62 . . . 757   695/696 (99%)   0.0           WO0200691 -  Homo sapiens      1 . . . 696   695/696 (99%)           (Human), 696 aa.       AAP12626   NEPH1 -  Rattus norvegicus  (Rat),   53 . . . 754   678/702 (96%)   0.0           702 aa (fragment).    1 . . . 702   688/702 (97%)                  
 
      PFam analysis predicts that the NOV12a protein contains the domains shown in the Table 12F.  
               TABLE 12F                          Domain Analysis of NOV12a                                             Identities/                       Similarities           Pfam   NOV12a   for the Matched   Expect           Domain   Match Region   Region   Value                       ig    35 . . . 102   12/72 (17%)   1.3e−05                   47/72 (65%)           ig   136 . . . 202   14/69 (20%)   0.0023                   48/69 (70%)           ig   322 . . . 373   21/55 (38%)   2.2e−09                   43/55 (78%)                      
 
     Example 13  
      The NOV13 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 13A.  
                   TABLE 13A                       NOV13 Sequence Analysis                                                NOV13a, CG51622-04   SEQ ID NO: 369   1826 bp           DNA Sequence   ORF Start: ATG at 167   ORF Stop: TGA at 1721                       AGGACTCCAGCGTGCCCAGTGACATAAACCCACTCTGCACATACCAGTTGCTCTGTCCCAGCTGTGCT               GCGGTGGTGCTGGGACAAAAGAAGCATGAGACGCAGACTCTGTCCCTCAAAGAACTCCCAGTGCAGGA           CAATGTGGTGCCCAAGGAAGACCCAGGGAC   ATG GGAGTGGAGGACAGTCAAAGAAGGGATCCTGGAAG       AGGTCTGGCATCCTGCACTTGCTGCCCTCTGACACCTGGGAAGATGGCCGGCCCGTGGACCTTCACCC       TTCTCTGTGGTTTGCTGGCAGCCACCTTGATCCAAGCCACCCTCAGTCCCACTGCAGTTCTCATCCTC       GGCCCAAAAGTCATCAAAGAAAAGCTGACACAGGAGCTGAAGGACCACAACGCCACCAGCATCCTGCA       GCAGCTGCCGCTGCTCAGTGCCATGCGGGAAAAGCCAGCCGGAGGCATCCCTGTGCTGGGCAGCCTGG       TGAACACCGTCCTGAAGCACATCATCTGGCTGAAGGTCATCACAGCTAACATCCTCCAGCTGCAGGTG       AAGCCCTCGGCCAATGACCAGGAGCTGCTAGTCAAGATCCCCCTGGACATGGTGGCTGGATTCAACAC       GCCCCTGGTCAAGACCATCGTGGAGTTCCACATGACGACTGAGGCCCAAGCCACCATCCGCATGGACA       CCAGTGCAAGTGGCCCCACCCGCCTGGTCCTCAGTGACTGTGCCACCAGCCATGGGAGCCTGCGCATC       CAACTGCTGCATAAGCTCTCCTTCCTGGTGAACGCCTTAGCTAAGCAGGTCATGAACCTCCTAGTGCC       ATCCCTGCCCAATCTAGTGAAAAACCAGCTGTGTCCCGTGATCGAGGCTTCCTTCAATGGCATGTATG       CAGACCTCCTGCAGCTGGTGAAGGTGCCCATTTCCCTCAGCATTGACCGTCTGGAGTTTGACCTTCTG       TATCCTGCCATCAAGGGTGACACCATTCAGCTCTACCTGGGGGCCAAGTTGTTGGACTCACAGGGAAA       GGTGACCAAGTGGTTCAATAACTCTGCAGCTTCCCTGACAATGCCCACCCTGGACAACATCCCGTTCA       GTCCTGTTGGACTCTGTGCTTCCTGAGAGTGCCCATCGGCTGAAGTCAAGCATCGGGCTGATCAATGA       AAAGGCTGCAGATAAGCTGGGATCTACCCAGATCGTGAAGATCCTAACTCAGGACACTCCCGAGTTTT       TTATAGACCAAGGCCATGCCAAGGTGGCCCAACTGATCGTGCTGGAAGTGTTTCCCTCCAGTGAAGCC       CTCCGCCCTTTGTTCACCCTGGGCATCGAAGCCAGCTCGGAAGCTCAGTTTTACACCAAAGGTGACCA       ACTTATACTCAACTTGAATAACATCAGCTCTGATCGGATCCAGCTGATGAACTCTGGGATTGGCTGGT       TCCAATGCCCCTTCTCTCTCTCACAGCCTGATGTTCTGAAAAACATCATCACTGAGATCATCCACTCC       ATCCTGCTGCCGAACCAGAATGGCAAATTAAGATCTGGGGTCCCAGTGTCATTGGTGAAGGCCTTGGG       CCAGCTCTCCTGTCTCCCAG TGA   AGACTTGGATGGCAGCCATCAGGGAAGGCTGGGTCCCAGCTGGGA           GTATGGGTGTGAGCTCTATAGACCATCCCTCTCTGCAATCAATAAACACTTGCCTGTG                                           NOV13a, CG51622-04                       Protein Sequence   SEQ ID NO: 370   518 aa   MW at 56020.9kD                     MGVEDSQRRDPGRGLASCTCCPLTPGKMAGPWTFTLLCGLLAATLIQATLSPTAVLILGPKVIKEKLT           QELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHIIWLKVITANILQLQVKPSANDQELL       VKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPTRLVLSDCATSHGSLRIQLLHKLSFLV       NALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGMYADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQ       LYLGAKLLDSQGKVTKWFNNSAASLTMPTLDNIPFSLIVSQDVVKAAVAAVLSPEEFMVLLDSVLPES       AHRLKSSIGLINEKAADKLGSTQIVKILTQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIE       ASSEAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQCPFSLSQPDVLKNIITEIIHSILLPNQNGKL       RSGVPVSLVKALGFEAAESSLTKDALVLTPASLWKPSSPVSQ                                     NOV13b, CG51622-03   SEQ ID NO: 371   1452 bp           DNA Sequence   ORF Start: ATG at 44   ORF Stop: TGA at 1346                       AGGTCTGCCATCCTGCACTTGCTGCCCTCTGACACCTGGGAAG   ATG GCCGGCCCGTGGACCTTCACCC           CTCTCTGTGGTTTGCTGGCAGCCACCTTGATCCAAGCCACCCTCAGTCCCACTGCAGTTCTCATCCTC       GGCCCAAAAGTCATCAAAGAAAAGCTGACACAGGAGCTGAAGGACCACAACGCCACCAGCATCCTGCA       GCAGCTGCCGCTGCTCAGTGCCATGCGGGAAAAGCCAGCCGGAGGCATCCCTGTGCTGGGCAGCCTGG       TGAACACCGTCCTGAAGCACGTCATCTGGCTGAAGGTCATCACAGCTAACATCCTCCAGCTGCAGGTG       AAGCCCTCGGCCAATGACCAGGAGCTGCTAGTCAAGATCCCCCTGGACATGGTGGCTGGATTCAACAC       GCTCTCCTTCCTGGTGAACGCCTTAGCTAAGCAGGTCATGAACCTCCTAGTGCCATCCCTGCCCAATC       TAGTGAAAAACCAGCTGTGTCCCGTGATCGAGGCTTCCTTCAATGGCATGTATGCAGACCTCCTGCAG       CTGGTGAAGGTGCCCATTTCCCTCAGCATTGACCGTCTGGAGTTTGACCTTCTGTATCCTGCCATCAA       GGGTGACACCATTCAGCTCTACCTGGGGGCCAAGTTGTTGGACTCACAGGGAAAGGTGACCAAGTGGT       TCAATAACTCTGCAGCTTCCCTGACAATGCCCACCCTGGACAACATCCCGTTCAGCCTCATCGTGAGT       CAGGACGTGGTGAAAGCTGCAGTGGCTGCTGTGCTCTCTCCAGAAGAATTCATGGTCCTGTTGGACTC       CATGCCAAGGTGGCCCAACTGATCGTGCTGGAAGTGTTTCCCTCCAGTGAAGCCCTCCGCCCTTTGTT       CACCCTGGGCATCGAAGCCAGCTCGGAAGCTCAGTTTTACACCAAAGGTGACCAACTTATACTCAACT       TGAATAACATCAGCTCTGATCGGATCCAGCTGATGAACTCTGGGATTGGCTGGTTCCAACCTGATGTT       CTGAAAAACATCATCACTGAGATCATCCACTCCATCCTGCTGCCGAACCAGAATGGCAAATTAAGATC       TGGGGTCCCAGTGTCATTGGTGAAGGCCTTGGGATTCGAGGCAGCTGAGTCCTCACTGAGCAAGGATG       CCCTTGTGCTTACTCCAGCCTCCTTGTGGAAACCCACCTCTCCTGTCTCCCAG TGA   AGACTTGGATGG           CAGCCATCAGGGAAGGCTGGGTCCCAGCTGGGAGTATGGGTGTGAGCTCTATAGACCATCCCTCTCTG           CAATCAATAAACACTTGCCTGTGA                                           NOV13b, CG51622-03                       Protein Sequence   SEQ ID NO: 372   1434 aa   MW at 46965.5kD                     MAGPWTFTPLCGLLAATLIQATLSPTAVLILGPKVIKEKLTQELKDHNATSILQQLPLLSAMREKPAG           GIPVLGSLVNTVLKHVIWLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTLSFLVNALAKQVMN       LLVPSLPNLVKNQLCPVIEASFNGMYADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLD       SQGKVTKWFNNSAASLTMPTLDNIPFSLIVSQDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIG       LINEKAADKLGSTQIVKILTQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIEASSEAQFYT       KGDQLILNLNNISSDRIQLNNSGIGWFQPDVLKNIITEIIHSILLPNQNGKLRSGVPVSLVKALGFEA       AESSLSKDALVLTPASLWKPTSPVSQ                                     NOV13c, CG51622-05   SEQ ID NO: 373   1580 bp           DNA Sequence   ORF Start: ATG at 77   ORF Stop: TGA at 1475                       AGAGAGGAGCGGGCCGAGGACTCCAGCGTGCCCAGGTCTGGCATCCTGCACTTGCTGCCCTCTGACAC               CTGGGAAG   ATG GCCGGCCCGTGGACCTTCACCCTTCTCTGTGGTTTGCTGGCAGCCACCTTGATCCAA       GCCACCCTCAGTCCCACTGCAGTTCTCATCCTCGGCCCAAAAGTCATCAAAGAAAAGCTGACACAGGA       GCTGAAGGACCACAACGCCACCAGCATCCTGCAGCAGCTGCCGCTGCTCAGTGCCATGCGGGAAAAGC       CAGCCGGAGGCATCCCTGTGCTGGGCAGCCTGGTGAACACCGTCCTGAAGCACGTCATCTGGCTGAAG       GTCATCACAGCTAACATCCTCCAGCTGCAGGTGAAGCCCTCGGCCAATGACCAGGAGCTGCTAGTCAA       GATCCCCCTGGACATGGTGGCTGGATTCAACACGCCCCTGGTCAAGACCATCGTGGAGTTCCACATGA       CGACTGAGGCCCAAGCCACCATCCGCATGGACACCAGTGCAAGTGGCCCCACCCGCCTGGTCCTCAGT       GACTGTGCCACCAGCCATGGGAGCCTGCGCATCCAACTGCTGCATAAGCTCTCCTTCCTGGTGAACGC       CTTAGCTAAGCAGGTCATGAACCTCCTAGTGCCATCCCTGCCCAATCTAGTGAAAAACCAGCTGGTGA       AGGTGCCCATTTCCCTCAGCATTGACCGTCTGGAGTTTGACCTTCTGTATCCTGCCATCAAGGGTGAC       ACCATTCAGCTCTACCTGGGGGCCAAGTTGTTGGACTCACAGGGAAAGGTGACCAAGTGGTTCAATAA       CTCTGCAGCTTCCCTGACAATGCCCACCCTGGACAACATCCCGTTCAGCCTCATCGTGAGTCAGGACG       TGGTGAAAGCTGCAGTGGCTGCTGTGCTCTCTCCAGAAGAATTCATGGTCCTGTTGGACTCTGTGCTT       CCTGAGAGTGCCCATCGGCTGAAGTCAAGCATCGGGCTGATCAATGAAAAGGCTGCAGATAAGCTGGG       ATCTACCCAGATCGTGAAGATCCTAACTCAGGACACTCCCGAGTTTTTTATAGACCAAGGCCATGCCA       AGGTGGCCCAACTGATCGTGCTGGAAGTGTTTCCCTCCAGTGAAGCCCTCCGCCCTTTGTTCACCCTG       GGCATCGAAGCCAGCTCGGAAGCTCAGTTTTACACCAAAGGTGACCAACTTATACTCAACTTGAATAA       CATCAGCTCTGATCGGATCCAGCTGATGAACTCTGGGATTGGCTGGTTCCAACCTGATGTTCTGAAAA       ACATCATCACTGAGATCATCCACTCCATCCTGCTGCCGAACCAGAATGGCAAATTAAGATCTGGGGTC       CCAGTGTCATTGGTGAAGGCCTTGGGATTCGAGGCAGCTGAGTCCTCACTGAGCAAGGATGCCCTTGT       GCTTACTCCAGCCTCCTTGTGGAAACCCACCTCTCCTGTCTCCCAG TGA   AGACTTGGATGGCAGCCAT           AGGGAAGGCTGGGTCCCAGCTGGGAGTATGGGTGTGAGCTCTATAGACCATCCCTCTCTGCAATCAA           TAAACACTTGCCTGTG                                           NOV13c, CG51622-05                       Protein Sequence   SEQ ID NO: 374   466 aa   MW at 50460.5kD                     MAGPWTFTLLCGLLAATLIQATLSPTAVLILGPKVIKEKLTQELKDHNATSILQQLPLLSAMREKPAG           GIPVLGSLVNTVLKHVIWLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTE       AQATIRMDTSASGPTRLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLVKVP       ISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLTMPTLDNIPFSLIVSQDVVK       AAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGLINEKAADKLGSTQIVKILTQDTPEFFIDQGHAKVA       QLIVLEVFPSSEALRPLFTLGIEASSEAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQPDVLKNII       TEIIHSILLPNQNGKLRSGVPVSLVKALGFEAAESSLSKDALVLTPASLWKPTSPVSQ                                     NOV13d, CG51622-01   SEQ ID NO: 375   963 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAA at 961                       ATG GCCGGCCCGTGGACCTTCACCCTTCTCTGTGGTTTGCTGGCAGCCACCTTGATCCAAGCCACCCT           CAGTCCCACTGCAGTTCTCATCCTCGGCCCAAAAGTCATCAAAGAAAGTCTGACACAGGAGCTGAAGG       ACCACAACGCCACCAGCATCCTGCAGCAGCTGCCGCTGCTCAGTGCCATGCGGGAAAAGCCAGCCGGA       GGCATCCCTGTGCTGGGCAGCCTGGTGAACACCGTCCTGAAGCACATCACCCCATCCAGGCTGAAGGT       CATCACAGCTAACATCCTCCAGCTGCAGGTGAAGCCCTCGGCCAATGACCAGGAGCTGCTAGTCAAGA       TCCCCCTGGACATGGTGGCTGGATTCAACACGCCCCTGGTCAAGACCATCGTGGAGTTCCACATGACG       ACTGAGGCCCAAGCCACCATCCGCATGGACACCAGTGCAAGTGGCCCCACCCGCCTGGTCCTCAGTGA       CTGTGCCACCAGCCATGGGAGCCTGCGCATCCAACTGCTGCATAAGCTCTCCTTCCTGGTGAACGCCT       TAGCTAAGCAGGTCATGAACCTCCTAGTGCCATCCCTGCCCAATCTAGTGAAAAACCAGCTGTGTCCC       GTGATCGAGGCTTCCTTCAATGGCATGTATGCAGACCTCCTGCAGCTGGTGAAGGGTAGGTGCTCTGC       TCTCTCTCCCACTTTTTCCTTTACTACGGAGCTGGCCTCCAGACCCGGAAAGGTGACCAAGTGGTTCA       ATAACTCTGCAGCTTCCCTGACAATGCCCACCCTGGACAACATCCCGTTCAGCCTCATCGTGAGTCAG       GACGTGGTGAAAGCTGCAGTGGCTGCTGTGCTCTCTCCAGAAGAATTCATGGTCCTGTTGGACTCTGT       GGTAAACCTCAGCACAAGGCAGAGAATAGGGCCGCCCAGGCCACATCATAGGAATTTCCTGAACACAG       GGTGCCCC TAA                                           Nov13d, CG51622-01                       Protein Sequence   SEQ ID NO: 376   320 aa   MW at 34533.2kD                     MAGPWTFTLLCGLLAATLIQATLSPTAVLILGPKVIKESLTQELKDHNATSILQQLPLLSAMREKPAG           GIPVLGSLVNTVLKHITPSRLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMT       TEAQATIRMDTSASGPTRLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCP       VIEASFNGMYADLLQLVKGRCSALSPTFSFTTELASRPGKVTKWFNNSAASLTMPTLDNIPFSLIVSQ       DVVKAAVAAVLSPEEFMVLLDSVVNLSTRQRIGPPRPHHRNFLNTGCP                                     NOV13e, 275698370   SEQ ID NO: 377   1024 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCACCATGGCCGGCCCGTGGACCTTCACCCTTCTCTGTGGTTTGCTGGCAGCCACCTTGA           TCCAAGCCACCCTCAGTCCCACTGCAGTTCTCATCCTCGGCCCAAAAGTCATCAAAGAAAAGCTGACA       CAGGAGCTGAAGGACCACAACGCCACCAGCATCCTGCAGCAGCTGCCGCTGCTCAGTGCCATGCGGGA       AAAGCCAGCCGGAGGCATCCCTGTGCTGGGCAGCCTGGTGAACACCGTCCTGAAGCACGTCATCTGGC       TGAAGGTCATCACAGCTAACATCCTCCAGCTGCAGGTGAAGCCCTCGGCCAATGACCAGGAGCTGCTA       GTCAAGATCCCCCTGGACATGGTGGCTGGATTCAACACGCCCCTGGTCAAGACCATCGTGGAGTTCCA       CATGACGACTGAGGCCCAAGCCACCATCCGCATGGACACCAGTGCAAGTGGCCCCACCCGCCTGGTCC       TCAGTGACTGTGCCACCAGCCATGGGAGCCTGCGCATCCAACTGCTGCATAAGCTCTCCTTCCTGGTG       GTGTCCCGTGATCGAGGCTTCCTTCAATGGCATGTATGCAGACCTCCTGCAGCTGGTGAAGGTGCCCA       TTTCCCTCAGCATTGACCGTCTGGAGTTTGACCTTCTGTATCCTGCCATCAAGGGTGACACCATTCAG       TTCCCTGACAATGCCCACCCTGGACAACATCCCGTTCAGCCTCATCGTGAGTCAGGACGTGGTGAAAG       CTGCAGTGGCTGCTGTGCTCTCTCCAGAAGAATTCATGGTCCTGTTGGACTCTGTGGTAAACCTCAGC       ACAAGGCAGAGAATAGGGCCGCCCAGGCCACATCATAGGAATTTCCTGAACACAGGGTGCCCCCTCGA       GGGC                                         NOV13e, 275698370                       Protein Sequence   SEQ ID NO: 378   341 aa   MW at 36955.1kD                     TGSTMAGPWTFTLLCGLLAATLIQATLSPTAVLILGPKVIKEKLTQELKDHNATSILQQLPLLSAMRE           KPAGGIPVLGSLVNTVLKHVIWLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFH       MTTEAQATIRMDTSASGPTRLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQL       CPVIEASFNGMYADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAA       SLTMPTLDNIPFSLIVSQDVVKAAVAAVLSPEEFMVLLDSVVNLSTRQRIGPPRPHHRNFLNTGCPLE       IG                                     NOV13f, 274054187   SEQ ID NO: 379   946 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCCCCACTGCAGTTCTCATCCTCGGCCCAAAAGTCATCAAAGAAAAGCTGACACAGGAGC           GCCGGAGGCATCCCTGTGCTGGGCAGCCTGGTGAACACCGTCCTGAAGCACGTCATCTGGCTGAAGGT       TCCCCCTGGACATGGTGGCTGGATTCAACACGCCCCTGGTCAAGACCATCGTGGAGTTCCACATGACG       ACTGAGGCCCAAGCCACCATCCGCATGGACACCAGTGCAAGTGGCCCCACCCGCCTGGTCCTCAGTGA       CTGTGCCACCAGCCATGGGAGCCTGCGCATCCAACTGCTGCATAAGCTCTCCTTCCTGGTGAACGCCT       TAGCTAAGCAGGTCATGAACCTCCTAGTGCCATCCCTGCCCAATCTAGTGAAAAACCAGCTGTGTCCC       GTGATCGAGGCTTCCTTCAATGGCATGTATGCAGACCTCCTGCAGCTGGTGAAGGTGCCCATTTCCCT       CAGCATTGACCGTCTGGAGTTTGACCTTCTGTATCCTGCCATCAAGGGTGACACCATTCAGCTCTACC       TGGGGGCCAAGTTGTTGGACTCACAGGGAAAGGTGACCAAGTGGTTCAATAACTCTGCAGCTTCCCTG       ACAATGCCCACCCTGGACAACATCCCGTTCAGCCTCATCGTGAGTCAGGACGTGGTGAAAGCTGCAGT       GGCTGCTGTGCTCTCTCCAGAAGAATTCATGGTCCTGTTGGACTCTGTGGTAAACCTCAGCACAAGGC       AGAGAATAGGGCCGCCCAGGCCACATCATAGGAATTTCCTGAACACAGGGTGCCCCCTCGAG                                         NOV13f, 274054187                       Protein Sequence   SEQ ID NO: 380   315 aa   MW at 34322.0kD                     TGSPTAVLILGPKVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHVIWLKV           ITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPTRLVLSD       CATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGMYADLLQLVKVPISL       SIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLTMPTLDNIPFSLIVSQDVVKAAV       AAVLSPEEFMVLLDSVVNLSTRQRIGPPRPHHRNFLNTGCPLE                                     NOV13g, CG51622-02   SEQ ID NO: 381   1035 bp           DNA Sequence   ORF Start: ATG at 79   ORF Stop: TAA at 1033                       AGAGCGTTGGGTCACGTGAGGACTCCAGCGTGCCCAGGTCTGGCATCCTGCACTTACTGCCCTCTGAC               ACCTGGGAAG   ATG GCCGGCCCGTGGACCTTCACCCTTCTCTGTGGTTTGCTGGCAGCCACCTTGATCC       AAGCCACCCTCAGTCCCACTGCAGTTCTCATCCTCGGCCCAAAAGTCATCAAAGAAAAGCTGACACAG       GAGCTGAAGGACCACAACGCCACCAGCATCCTGCAGCAGCTGCCGCTGCTCAGTGCCATGCGGGAAAA       GCCAGCCGGAGGCATCCCTGTGCTGGGCAGCCTGGTGAACACCGTCCTGAAGCACATCATCTGGCTGA       AGGTCATCACAGCTAACATCCTCCAGCTGCAGGTGAAGCCCTCGGCCAATGACCAGGAGCTGCTAGTC       AAGATCCCCCTGGACATGGTGGCTGGATTCAACACGCCCCTGGTCAAGACCATCGTGGAGTTCCACAT       GACGACTGAGGCCCAAGCCACCATCCGCATGGACACCAGTGCAAGTGGCCCCACCCGCCTGGTCCTCA       GTGACTGTGCCACCAGCCATGGGAGCCTGCGCATCCAACTGCTGCATAAGCTCTCCTTCCTGGTGAAC       GCCTTAGCTAAGCAGGTCATGAACCTCCTAGTGCCATCCCTGCCCAATCTAGTGAAAAACCAGCTGTG       TCCCGTGATCGAGGCTTCCTTCAATGGCATGTATGCAGACCTCCTGCAGCTGGTGAAGGGTAGGTGCT       CTGCTCTCTCTCCCACTTTTTCCTTTACTACGGAGCTGGCCTCCAGACCCGGAAAGGTGACCAAGTGG       TTCAATAACTCTGCAGCTTCCCTGACAATGCCCACCCTGGACAACATCCCGTTCAGCCTCATCGTGAG       TCAGGACGTGGTGAAAGCTGCAGTGGCTGCTGTGCTCTCTCCAGAAGAATTCATGGTCCTGTTGGACT       CTGTGGTAAACCTCAGCACAAGGCAGAGAATAGGGCCGCCCAGGCCACATCATAGGAATTTCCTGAAC       ACAGGGTGCCCC TAA                                           NOV13g, CG51622-02                       Protein Sequence   SEQ ID NO: 382   318 aa   MW at 34432.2kD                     MAGPWTFTLLCGLLAATLIQATLSPTAVLILGPKVIKEKLTQELKDHNATSILQQLPLLSAMREKPAG           GIPVLGSLVNTVLKHIIWLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTE       AQATIRMDTSASGPTRLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVI       EASFNGMYADLLQLVKGRCSALSPTFSFTTELASRPGKVTKWFNNSAASLTMPTLDNIPFSLIVSQDV       IVKAAVAAVLSPEEFMVLLDSVVNLSTRQRIGPPRPHHRNFLNTGCP                                     NOV13h, CG51622-06   SEQ ID NO: 383   1572 bp           DNA Sequence   ORF Start: ATG at 124   ORF Stop: TGA at 1441                       GGTGTGCAGGATATAAGGTTGGACTTCCAGACCCACTGCCCGGGAGAGGAGAGGAGCGGGCCGAGGAC               TCCAGCGTGCCCAGGTCTGGCATCCTGCACTTGCTGCCCTCTGACACCTGGGAAG   ATG GCCGGCCCGT       GGACCTTCACCCTTCTCTGTGGTTTGCTGGCAGCCACCTTGATCCAAGCCACCCTCAGTCCCACTGCA       GTTCTCATCCTCGGCCCAAAAGTCATCAAAGAAAAGCTGACACAGGAGCTGAAGGACCACAACGCCAC       CAGCATCCTGCAGCAGCTGCCGCTGCTCAGTGCCATGCGGGAAAAGCCAGCCGGAGGCATCCCTGTGC       TGGGCAGCCTGGTGAACACCGTCCTGAAGCACATCATCTGGCTGAAGGTCATCACAGCTAACATCCTC       CAGCTGCAGGTGAAGCCCTCGGCCAATGACCAGGAGCTGCTAGTCAAGATCCCCCTGGACATGGTGGC       TGGATTCAACACGCCCCTGGTCAAGACCATCGTGGAGTTCCACATGACGACTGAGGCCCTTGCCACCA       TCCGCATGGACACCAGTGCAAGTGGCCCCACCCGCCTGGTCCTCAGTGACTGTGCCACCAGCCATGGG       AGCCTGCGCATCCAACTGCTGCATAAGCTCTCCTTCCTGGTGAACGCCTTAGCTAAGCAGGTCATGAA       CCTCCTAGTGCCATCCCTGCCCAATCTAGTGAAAAACCAGCTGTGTCCCGTGATCGAGGCTTCCTTCA       ATGGCATGTATGCAGACCTCCTGCAGCTGGTGAAGGTGCCCATTTCCCTCAGCATTGACCGTCTGGAG       TTTGACCTTCTGTATCCTGCCATCAAGGGTGACACCATTCAGCTCTACCTGGGGGCCAAGTTGTTGGA       CTCACAGGGAAAGGTGACCAAGTGGTTCAATAACTCTGCAGCTTCCCTGACAATGCCCACCCTGGACA       ACATCCCGTTCAGCCTCATCGTGAGTCACCCGTTCAGCCTCATCGTGAGTCAGGACGTGGTGAAAGCT       GCAGTGGCTGCTGTGCTCTCTCCAGAAGAATTCATGGTCCTGTTGGACTCTGTGCTTCCTGAGAGTGC       CCATCGGCTGAAGTCAAGCATCGGGCTGATCAATGAAAAGGAAGCCAGCTCGGAAGCTCAGTTTTACA       CCAAAGGTGACCAACTTATACTCAACTTGAATAACATCAGCTCTGATCGGATCCAGCTGATGAACTCT       GGGATTGGCTGGTTCCAACCTGATGTTCTGAAAAACATCATCACTGAGATCATCCACTCCATCCTGCT       CAGCTGAGTCCTCACTGACCAAGGATGCCCTTGTGCTTACTCCAGCCTCCTTGTGGAAACCCAGCTCT       CCTGTCTCCCAG TGA   AGACTTGGATGGCAGCCATCAGGGAAGGCTGGGTCCCAGTTGGGAGTATGGGT           GTGAGCTCTATAGACCATCCCTCTCTGCAATCAATAAACACTTGCCTGTGAAAAAAAAAAAAAAATAA           AAAAAAAA                                           NOV13h, CG51622-06                       Protein Sequence   SEQ ID NO: 384   439 aa   MW at 47572.2kD                     MAGPWTFTLLCGLLAATLIQATLSPTAVLILGPKVIKEKLTQELKDHNATSILQQLPLLSAMREKPAG           GIPVLGSLVNTVLKHIIWLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTE       AQATIRMDTSASGPTRLXTSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVI       EASFNGMYADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLTM       PTLDNIPFSLIVSHPFSLIVSQDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGLINEKEASSE       LGFEAAESSLTKDALVLTPASLWKPSSPVSQ                                     NOV13i, CG51622-07   SEQ ID NO: 385   1023 bp           DNA Sequence   ORF Start: ATG at 19   ORF Stop: TAA at 1021                       CCTCTGACACCTGGGAAG   ATG GCCGGCCCGTGGACCTTCACCCTTCTCTGTGGTTTGCTGGCAGCCAC           CTTGATCCAAGCCACCCTCAGTCCCACTGCAGTTCTCATCCTCGGCCCAAAAGTCATCAAAGAAAAGC       TGACACAGGAGCTGAAGGACCACAACGCCACCAGCATCCTGCAGCAGCTGCCGCTGCTCAGTGCCATG       CGGGAAAAGCCAGCCGGAGGCATCCCTGTGCTGGGCAGCCTGGTGAACACCGTCCTGAAGCACGTCAT       CTGGCTGAAGGTCATCACAGCTAACATCCTCCAGCTGCAGGTGAAGCCCTCGGCCAATGACCAGGAGC       TGCTAGTCAAGATCCCCCTGGACATGGTGGCTGGATTCAACACGCCCCTGGTCAAGACCATCGTGGAG       TTCCACATGACGACTGAGGCCCAAGCCACCATCCGCATGGACACCAGTGCAAGTGGCCCCACCCGCCT       GGTCCTCAGTGACTGTGCCACCAGCCATGGGAGCCTGCGCATCCAACTGCTGCATAAGCTCTCCTTCC       TGGTGAACGCCTTAGCTAAGCAGGTCATGAACCTCCTAGTGCCATCCCTGCCCAATCTAGTGAAAAAC       GCCCATTTCCCTCAGCATTGACCGTCTGGAGTTTGACCTTCTGTATCCTGCCATCAAGGGTGACACCA       TTCAGCTCTACCTGGGGGCCAAGTTGTTGGACTCACAGGGAAAGGTGACCAAGTGGTTCAATAACTCT       GCAGCTTCCCTGACAATGCCCACCCTGGACAACATCCCGTTCAGCCTCATCGTGAGTCAGGACGTGGT       GAAAGCTGCAGTGGCTGCTGTGCTCTCTCCAGAAGAATTCATGGTCCTGTTGGACTCTGTGGTAAACC       TCAGCACAAGGCAGAGAATAGGGCCGCCCAGGCCACATCATAGGAATTTCCTGAACACAGGGTGCCCC         TAA                                           NOV13l, CG51622-07                       Protein Sequence   SEQ ID NO: 386   334 aa   MW at 36309.5kD                     MAGPWTFTLLCGLLAATLIQATLSPTAVLILGPKVIKEKLTQELKDHNATSILQQLPLLSAMREKPAG           GIPVLGSLVNTVLKHVIWLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTE       AQATIRMDTSASGPTRLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVI       EASFNGMYADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLTM       PTLDNIPFSLIVSQDVVKAAVAAVLSPEEFMVLLDSVVNLSTRQRIGPPRPHHRNFLNTGCP                                     NOV13j, CG51622-08   SEQ ID NO: 387   1509 bp           DNA Sequence   ORF Start: ATG at 31   ORF Stop: TGA at 1480                       TGCACTTGCTGCCCTCTGACACCTGGGAAG   ATG GCCGGCCCGTGGACCTTCACCCTTCTCTGTGGTTT           GCTGGCAGCCACCTTGATCCAAGCCACCCTCAGTCCCACTGCAGTTCTCATCCTCGGCCCAAAAGTCA       TCAAAGAAAAGCTGACACAGGAGCTGAAGGACCACAACGCCACCAGCATCCTGCAGCAGCTGCCGCTG       CTCAGTGCCATGCGGGAAAAGCCAGCCGGAGGCATCCCTGTGCTGGGCAGCCTGGTGAACACCGTCCT       GAAGCACATCATCTGGCTGAAGGTCATCACAGCTAACATCCTCCAGCTGCAGGTGAAGCCCTCGGCCA       ATGACCAGGAGCTGCTAGTCAAGATCCCCCTGGACATGGTGGCTGGATTCAACACGCCCCTGGTCAAG       ACCATCGTGGAGTTCCACATGACGACTGAGGCCCAAGCCACCATCCGCATGGACACCAGTGCAAGTGG       CCCCACCCGCCTGGTCCTCAGTGACTGTGCCACCAGCCATGGGAGCCTGCGCATCCAACTGCTGCATA       AGCTCTCCTTCCTGGTGAACGCCTTAGCTAAGCAGGTCATGAACCTCCTAGTGCCATCCCTGCCCAAT       CTAGTGAAAAACCAGCTGTGTCCCGTGATCGAGGCTTCCTTCAATGGCATGTATGCAGACCTCCTGCA       GCTGGTGAAGGTGCCCATTTCCCTCAGCATTGACCGTCTGGAGTTTGACCTTCTGTATCCTGCCATCA       AGGGTGACACCATTCAGCTCTACCTGGGGGCCAAGTTGTTGGACTCACAGGGAAAGGTGACCAAGTGG       TTCAATAACTCTGCAGCTTCCCTGACAATGCCCACCCTGGACAACATCCCGTTCAGCCTCGTGAGTCA       GGACGTGGTGAAAGCTGCAGTGGCTGCTGTGCTCTCTCCAGAAGAATTCATGGTCCTGTTGGACTCTG       TGCTTCCTGAGAGTGCCCATCGGCTGAAGTCAAGCATCGGGCTGATCAATGAAAAGGCTGCAGATAAG       CTGGGATCTACCCAGATCGTGAAGATCCTAACTCAGGACACTCCCGAGTTTTTTATAGACCAAGGCCA       TGCCAAGGTGGCCCAACTGATCGTGCTGGAAGTGTTTCCCTCCAGTGAAGCCCTCCGCCCTTTGTTCA       AATAACATCAGCTCTGATCGGATCCAGCTGATGAACTCTGGGATTGGCTGGTTCCAACCTGATGTTCT       GAAAAACATCATCACTGAGATCATCCACTCCATCCTGCTGCCGAACCAGAATGGCAAATTAAGATCTG       GGGTCCCAGTGTCATTGGTGAAGGCCTTGGGATTCGAGGCAGCTGAGTCCTCACTGACCAAGGATGCC       CTTGTGCTTACTCCAGCCTCCTTGTGGAAACCCAGCTCTCCTGTCTCCCAG TGA   AGACTTGGATGGCA           GCCATCAGGGAAG                                           NOV13j, CG51622-08                       Protein Sequence   SEQ ID NO: 388   1483 aa   MW at 52327.7kD                     MAGPWTFTLLCGLLAATLIQATLSPTAVLILGPKVTKEKLTQELKDHNATSILQQLPLLSAMREKPAG           GIPVLGSLVNTVLKHIIWLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTE       AQATIRMDTSASGPTRLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVI       EASFNGMYADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLTM       PTLDNIPFSLVSQDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGLINEKAADKLGSTQIVKIL       TQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIEASSEAQFYTKGDQLILNLNNISSDRIQL       MNSGIGWFQPDVLKNIITEIIHSILLPNQNGKLRSGVPVSLVKALGFEAAESSLTKDALVLTPASLWK       PSSPVSQ                                     NOV13k, CG51622-09   SEQ ID NO: 389   1392 bp           DNA Sequence   ORF Start: at 7   ORF Stop: at 1387                       AAGCTT CCCACTGCAGTTCTCATCCTCGGCCCAAAAGTCATCAAAGAAAAGCTGACACAGGAGCTGAA           GGACCACAACGCCACCAGCATCCTGCAGCAGCTGCCGCTGCTCAGTGCCATGCGGGAAAAGCCAGCCG       GAGGCATCCCTGTGCTGGGCAGCCTGGTGAACACCGTCCTGAAACACATCATCTGGCTGATGGTCATC       ACAGCTAACATCCTCCAGCTGCAGGTGAAGCCCTCGGCCAATGACCAGGAGCTGCTAGTCAAGATCCC       CCTGGACATGGTGGCTGGATTCAACACGCCCCTGGTCAAGACCATCGTGGAGTTCCACATGACGACTG       AGGCCCAAGCCACCATCCGCATGGACACCAGTGCAAGTGGCCCCACCCGCCTGGTCCTCAGTGACTGT       GCCACCAGCCATGGGAGCCTGCGCATCCAACTGCTGCATAAGCTCTCCTTCCTGGTGAACGCCTTAGC       TAAGCAGGTCATGAACCTCCTAGTGCCGTCCCTGCCCAATCTAGTGAAAAACCAGCTGTGTCCCGTGA       TCGAGGCTTCCTTCAATGGCATGTATGCAGACCTCCTGCAGCTGGTGAAGGTGCCCATTTCCCTCAGC       ATTGACCGTCTGGAGTTTGACCTTCTGTATCCTGCCATCAAGGGTGACACCATTCAGCTCTACCTGGG       GGCCAAGTTGTTGGACTCACAGGGAAAGGTGACCAAGTGGTTCAATAACTCTGCAGCTTCCCTGACAA       TGCCCACCCTGGACAACATCCCGTTCAGCCTCATCGTGAGTCAGGACGTGGTGAAAGCTGCAGTGGCT       GCTGTGCTCTCTCCAGAAGAATTCATGGTCCTGTTGGACTCTGTGCTTCCTGAGAGTGCCCATCGGCT       GAAGTCAAGCATCGGGCTGATCAATGAAAAGGCTGCAGATAAGCTGGGACCTACCCAGATCGTGAAGA       TCCTAACTCAGGACACTCCCGAGTTTTTTATAGACCAAGGCCATGCCAAGGTGGCCCAACTGATCGTG       CTGGAAGTGTTTCCCTCCAGTGAAGCCCTCCGCCCTTTGTTCACCCTGGGCATCGAAGCCAGCTCGGA       AGCTCAGTTTTACACCAAAGGTGACCAACTTATACTCAACTTGAATAACATCAGCTCTGATCGGATCC       AGCTGATGAACTCTGGGATTGGCTGGTTCCAACCTGATGTTCTGAAAAACATCATCACTGAGATCATC       CACTCCATCCTGCTGCCGAACCAGAATGGCAAATTAAGATCTGGGGTCCCAGTGTCATTGGTGAAGGC       CTTGGGATTCGAGGCAGCTGAGTCCTCACTGACCAAGGATGCCCTTGTGCTTACTCCAGCCTCCTTGT       GGAAACCCAGCTCTCCTGTCTCCCAGCTC GAG                                           NOV13k, CG51622-09                       Protein Sequence   SEQ ID NO: 390   460 aa   MW at 49975.9kD                     PTAVLILGPKVIKEKLTQELKDHNATSILQQLPLLSANREKPAGGIPVLGSLVNTVLKHIIWLKVITA           NILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPTRLVLSDCAT       SHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGMYADLLQLVKVPISLSID       RLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLTMPTLDNIPFSLIVSQDVVKAAVAAV       LSPEEFMVLLDSVLPESAHRLKSSIGLINEKAADKLGPTQIVKILTQDTPEFFIDQGHAKVAQLIVLE       VFPSSEALRPLFTLGIEASSEAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQPDVLKNIITEIIHS       ILLPNQNGKLRSGVPVSLVKALGFEAAESSLTKDALVLTPASLWKPSSPVSQ                                     NOV13l, CG51622-10   SEQ ID NO: 391   1684 bp           DNA Sequence   ORF Start: ATG at 77   ORF Stop: TGA at 1529         AGAGAGGAGCGGGCCGAGGACTCCAGCGTGCCCAGGTCTGGCATCCTGCACTTGCTGCCCTCTGACAC           CTGGGAAG   ATG GCCGGCCCGTGGACCTTCACCCTTCTCTGTGGTTTGCTGGCAGCCACCTTGATCCAA       GCCACCCTCAGTCCCACTGCAGTTCTCATCCTCGGCCCAAAAGTCATCAAAGAAAAGCTGACACAGGA       GCTGAAGGACCACAACGCCACCAGCATCCTGCAGCAGCTGCCGCTGCTCAGTGCCATGCGGGAAAAGC       CAGCCGGAGGCATCCCTGTGCTGGGCAGCCTGGTGAACACCGTCCTGAAGCACGTCATCTGGCTGAAG       GTCATCACAGCTAACATCCTCCAGCTGCAGGTGAAGCCCTCGGCCAATGACCAGGAGCTGCTAGTCAA       GATCCCCCTGGACATGGTGGCTGGATTCAACACGCCCCTGGTCAAGACCATCGTGGAGTTCCACATGA       CGACTGAGGCCCAAGCCACCATCCGCATGGACACCAGTGCAAGTGGCCCCACCCGCCTGGTCCTCAGT       GACTGTGCCACCAGCCATGGGAGCCTGCGCATCCAACTGCTGCATAAGCTCTCCTTCCTGGTGAACGC       CTTAGCTAAGCAGGTCATGAACCTCCTAGTGCCATCCCTGCCCAATCTAGTGAAAAACCAGCTGTGTC       CGTGATCTGAGGCTTCCTTCAATGGCATGTATGCAGACCTCCTGCAGCTGGTGAAGGTGCCCATTTCC       TCAGCATTGAACCGTCTGGAGTTTGACCTTCTGTATCCTGCCATCAAGGGTGACACCATTCAGCTCTA       CCTGGGGGCCAAGTTGTTGGACTCACAGGGAAAGGTGACCAAGTGGTTCAATAACTCTGCAGCTTCCC       TGACAATGCCCACCCTGGACAACATCCCGTTCAGCCTCATCGTGAGTCAGGACGTGGTGAAAGCTGCA       GTGGCTGCTGTGCTCTCTCCAGAAGAATTCATGGTCCTGTTGGACTCTGTGCTTCCTGAGAGTGCCCA       TCGGCTGAAGTCAAGCATCGGGCTGATCAATGAAAAGGCTGCAGATAAGCTGGGATCTACCCAGATCG       TGAAGATCCTAACTCAGGACACTCCCGAGTTTTTTATAGACCAAGGCCATGCCAAGGTGGCCCAACTG       ATCGTGCTGGAAGTGTTTCCCTCCAGTGAAGCCCTCCGCCCTTTGTTCACCCTGGGCATCGAAGCCAG       CTCGGAAGCTCAGTTTTACACCAAAGGTGACCAACTTATACTCAACTTGAATAACATCAGCTCTGATC       GGATCCAGCTGATGAACTCTGGGATTGGCTGGTTCCAACCTGATGTTCTGAAAAACATCATCACTGAG       ATCATCCACTCCATCCTGCTGCCGAACCAGAATGGCAAATTAAGATCTGGGGTCCCAGTGTCATTGGT       GAAGGCCTTGGGATTCGAGGCAGCTGAGTCCTCACTGAGCAAGGATGCCCTTGTGCTTACTCCAGCCT       CCTTGTGGAAACCCACCTCTCCTGTCTCCCAG TGA   AGACTTGGATGGCAGCCATCAGGGAAGGCTGGG           TCCCAGCTGGGAGTATGGGTGTGAGCTCTATAGACCATCCCTCTCTGCAATCAATAAACACTTGCCTG           TGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA                                           NOV13l, CG51622-10                       Protein Sequence   SEQ ID NO: 392   484 aa   MW at 52426.8kD                     MAGPWTFTLLCGLLAATLIQATLSPTAVLILGPKVIKEKLTQELKDHNATSILQQLPLLSAMREKPAG           GIPVLGSLVNTVLKHVIWLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTE       AQATIRMDTSASGPTRLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVI       EASFNGMYADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLTM       PTLDNIPFSLIVSQDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGLINEKAADKLGSTQIVKI       LTQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIEASSEAQFYTKGDQLILNLNNISSDRIQ       LMNSGIGWFQPDVLLNIITEIIHSILLPNQNGKLRSGVPVSLVKALGFEAAESSLSKDALVLTPASLW       KPTSPVSQ                                     NOV13m,                   SNP13375774 of   SEQ ID NO: 393   963 bp       CG51622-01,   ORF Start: ATG at 1   ORF Stop: TAA at 961       DNA Sequence   SNP Pos: 248   SNP Change: A to G                       ATG GCCGGCCCGTGGACCTTCACCCTTCTCTGTGGTTTGCTGGCAGCCACCTTGATCCAAGCCACCCT           CAGTCCCACTGCAGTTCTCATCCTCGGCCCAAAAGTCATCAAAGAAAGTCTGACACAGGAGCTGAAGG       ACCACAACGCCACCAGCATCCTGCAGCAGCTGCCGCTGCTCAGTGCCATGCGGGAAAAGCCAGCCGGA       GGCATCCCTGTGCTGGGCAGCCTGGTGAACACCGTCCTGAAGC   G   CATCACCCCATCCAGGCTGAAGGT       CATCACAGCTAACATCCTCCAGCTGCAGGTGAAGCCCTCGGCCAATGACCAGGAGCTGCTAGTCAAGA       TCCCCCTGGACATGGTGGCTGGATTCAACACGCCCCTGGTCAAGACCATCGTGGAGTTCCACATGACG       ACTGAGGCCCAAGCCACCATCCGCATGGACACCAGTGCAAGTGGCCCCACCCGCCTGGTCCTCAGTGA       CTGTGCCACCAGCCATGGGAGCCTGCGCATCCAACTGCTGCATAAGCTCTCCTTCCTGGTGAACGCCT       TAGCTAAGCAGGTCATGAACCTCCTAGTGCCATCCCTGCCCAATCTAGTGAAAAACCAGCTGTGTCCC       GTGATCGAGGCTTCCTTCAATGGCATGTATGCAGACCTCCTGCAGCTGGTGAAGGGTAGGTGCTCTGC       TCTCTCTCCCACTTTTTCCTTTACTACGGAGCTGGCCTCCAGACCCGGAAAGGTGACCAAGTGGTTCA       ATAACTCTGCAGCTTCCCTGACAATGCCCACCCTGGACAACATCCCGTTCAGCCTCATCGTGAGTCAG       GGTAAACCTCAGCACAAGGCAGAGAATAGGGCCGCCCAGGCCACATCATAGGAATTTCCTGAACACAG       GGTGCCCC TAA                                           NOV13m,                       SNP13375774 of       CG51622-01,   SEQ ID NO: 394       MW at 34552.3kD       Protein Sequence   SNP Pos: 83   320 aa   SNP Change: His to Arg                     MAGPWTFTLLCGLLAATLIQATLSPTAVLILGPKVIKESLTQELKDHNATSILQQLPLLSAMREKPAG           GIPVLGSLVNTVLK   R   ITPSRLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHNT       TEAQATIRMDTSASGPTRLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCP       VIEASFNGMYADLLQLVKGRCSALSPTFSFTTELASRPGKVTKWFNNSAASLTMPTLDNIPFSLIVSQ       DVVKAAVAAVLSPEEFMVLLDSVVNLSTRQRIGPPRPHHRNFLNTGCP                                     NOV13n,                   SNP1 3375775 of   SEQ ID NO: 395   963 bp       CG51622-01,   ORF Start: ATG at 1   ORF Stop: TAA at 961       DNA Sequence   SNP Pos: 250   SNP Change: A to G                       ATG GCCGGCCCGTGGACCTTCACCCTTCTCTGTGGTTTGCTGGCAGCCACCTTGATCCAAGCCACCCT           CAGTCCCACTGCAGTTCTCATCCTCGGCCCAAAAGTCATCAAAGAAAGTCTGACACAGGAGCTGAAGG       ACCACAACGCCACCAGCATCCTGCAGCAGCTGCCGCTGCTCAGTGCCATGCGGGAAAAGCCAGCCGGA       GGCATCCCTGTGCTGGGCAGCCTGGTGAACACCGTCCTGAAGCAC   G   TCACCCCATCCAGGCTGTTGGT       CATCACAGCTAACATCCTCCAGCTGCAGGTGAAGCCCTCGGCCAATGACCAGGAGCTGCTAGTCAAGA       TCCCCCTGGACATGGTGGCTGGATTCAACACGCCCCTGGTCAAGACCATCGTGGAGTTCCACATGACG       ACTGAGGCCCAAGCCACCATCCGCATGGACACCAGTGCAAGTGGCCCCACCCGCCTGGTCCTCAGTGA       CTGTGCCACCAGCCATGGGAGCCTGCGCATCCAACTGCTGCATAAGCTCTCCTTCCTGGTGAACGCCT       TAGCTAAGCAGGTCATGAACCTCCTAGTGCCATCCCTGCCCAATCTAGTGAAAAACCAGCTGTGTCCC       GTGATCGAGGCTTCCTTCAATGGCATGTATGCAGACCTCCTGCAGCTGGTGAAGGGTAGGTGCTCTGC       TCTCTCTCCCACTTTTTCCTTTACTACGGAGCTGGCCTCCAGACCCGGAAAGGTGACCAAGTGGTTCA       ATAACTCTGCAGCTTCCCTGACAATGCCCACCCTGGACAACATCCCGTTCAGCCTCATCGTGAGTCAG       GACGTGGTGAAAGCTGCAGTGGCTGCTGTGCTCTCTCCAGAAGAATTCATGGTCCTGTTGGACTCTGT       GGTAAACCTCAGCACAAGGCAGAGAATAGGGCCGCCCAGGCCACATCATAGGAATTTCCTGAACACAG       GGTGCCCC TAA                                           NOV13n,                       SNP13375775 of       CG51622-01,   SEQ ID NO: 396       MW at 3451 9.2kD       Protein Sequence   SNP Pos: 84   320 aa   SNP Change: Ile to Val                     MAGPWTFTLLCGLLAATLIQATLSPTAVLILGPKVIKESLTQELKDHNATSILQQLPLLSAMREKPAG           GIPVLGSLVNTVLKH   V   TPSRLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMT       TEAQATIPMDTSAsGPTRLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVNNLLVPSLPNLVKNQLCP       VIEASFNGMYADLLQLVKGRCSALSPTFSFTTELASRPGKVTKWFNNSAASLTMPTLDNIPFSLIVSQ       DVVKAAVAAVLSPEEFMVLLDSVVNLSTRQRIGPPRPHHRNFLNTGCP                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 13B.  
               TABLE 13B                       Comparison of the NOV13 protein sequences.                                            NOV13a   MGVEDSQRRDPGRGLASCTCCPLTPGKMAGPWTFTLLCGLLAATLIQATLSPTAVLILGP           NOV13b   ---------------------------MAGPWTFTPLCGLLAATLIQATLSPTAVLILGP       NOV13c   ---------------------------MAGPWTFTLLCGLLAATLIQATLSPTAVLILGP       NOV13d   ---------------------------MAGPWTFTLLCGLLAATLIQATLSPTAVLILGP       NOV13e   -----------------------TGSTMAGPWTFTLLCGLLAATLIQATLSPTAVLILGP       NOV13f   ------------------------------------------------TGSPTAVLILGP       NOV13g   ---------------------------MAGPWTFTLLCGLLAATLIQATLSPTAVLILGP       NOV13h   ---------------------------MAGPWTFTLLCGLLAATLIQATLSPTAVLILGP       NOV13i   ---------------------------MAGPWTFTLLCGLLAATLIQATLSPTAVLILGP       NOV13j   ---------------------------MAGPWTFTLLCGLLAATLIQATLSPTAVLILGP       NOV13k   ---------------------------------------------------PTAVLILGP       NOV13l   ---------------------------MAGPWTFTLLCGLLAATLIQATLSPTAVLILGP               NOV13a   KVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHII--WLKVIT       NOV13b   KVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHVI--WLKVIT       NOV13c   KVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHVI--WLKVIT       NOV13d   KVIKESLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHITPSRLKVIT       NOV13e   KVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHVI--WLKVIT       NOV13f   KVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHVI--WLKVIT       NOV13g   KVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHII--WLKVIT       NOV13h   KVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHII--WLKVIT       NOV13i   KVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHVI--WLKVIT       NOV13j   KVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHII--WLKVIT       NOV13k   KVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHII--WLKVIT       NOV13l   KVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHVI--WLKVIT               NOV13a   ANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPT       NOV13b   ANILQLQVKPSANDQELLVKIPLDMVAGFNT-----------------------------       NOV13c   ANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPT       NOV13d   ANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPT       NOV13e   ANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPT       NOV13f   ANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPT       NOV13g   ANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPT       NOV13h   ANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPT       NOV13i   ANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPT       NOV13j   ANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPT       NOV13k   ANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPT       NOV13l   ANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPT               NOV13a   RLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGM       NOV13b   ---------------------LSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGM       NOV13c   RLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKN-------------       NOV13d   RLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGM       NOV13e   RLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGM       NOV13f   RLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGM       NOV13g   RLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGM       NOV13h   RLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGM       NOV13i   RLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGM       NOV13j   RLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGM       NOV13k   RLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGM       NOV13l   RLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGM               NOV13a   YADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLT       NOV13b   YADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLT       NOV13c   -----QLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLT       NOV13d   YADLLQLVKGRCSALSPTFSFTTELASRP------------G----KVTKWFNNSAASLT       NOV13e   YADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLT       NOV13f   YADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLT       NOV13g   YADLLQLVKGRCSALSPTFSFTTELASRP------------G----KVTKWFNNSAASLT       NOV13h   YADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLT       NOV13i   YADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLT       NOV13j   YADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLT       NOV13k   YADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLT       NOV13l   YADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLT               NOV13a   MPTLDNIPFSLIVS--------QDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGL       NOV13b   MPTLDNIPFSLIVS--------QDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGL       NOV13c   MPTLDNIPFSLIVS--------QDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGL       NOV13d   MPTLDNIPFSLIVS--------QDVVKAAVAAVLSPEEFMVLLDSVVNLSTRQRIG----       NOV13e   MPTLDNIPFSLIVS--------QDVVKAAVAAVLSPEEFMVLLDSVVNLSTRQRIG----       NOV13f   MPTLDNIPFSLIVS--------QDVVKAAVAAVLSPEEFMVLLDSVVNLSTRQRIG----       NOV13g   MPTLDNIPFSLIVS--------QDVVKAAVAAVLSPEEFMVLLDSVVNLSTRQRIG----       NOV13h   MPTLDNIPFSLIVSHPFSLIVSQDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGL       NOV13i   MPTLDNIPFSLIVS--------QDVVKAAVAAVLSPEEFMVLLDSVVNLSTRQRIG----       NOV13j   MPTLDNIPFSLVS---------QDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGL       NOV13k   MPTLDNIPFSLIVS--------QDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGL       NOV13l   MPTLDNIPFSLIVS--------QDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGL               NOV13a   INEKAADKLGSTQIVKILTQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIEAS       NOV13b   INEKAADKLGSTQIVKILTQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIEAS       NOV13c   INEKAADKLGSTQIVKILTQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIEAS       NOV13d   ----------------------P--------------------P-----RP---------       NOV13e   ----------------------P--------------------P-----RP---------       NOV13f   ----------------------P--------------------P-----RP---------       NOV13g   ----------------------P--------------------P-----RP---------       NOV13h   INEK-----------------------------------------------------EAS       NOV13i   ----------------------P--------------------P-----RP---------       NOV13j   INEKAADKLGSTQIVKILTQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIEAS       NOV13k   INEKAADKLGPTQIVKILTQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIEAS       NOV13l   INEKAADKLGSTQIVKILTQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIEAS               NOV13a   SEAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQCPFSLSQPDVLKNIITEIIHSILLP       NOV13b   SEAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQ-------PDVLKNIITEIIHSILLP       NOV13c   SEAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQ-------PDVLKNIITEIIHSILLP       NOV13d   HHRNFLNTGCP-------------------------------------------------       NOV13e   HHRNFLNTGCPLEG----------------------------------------------       NOV13f   HHRNFLNTGCPLE-----------------------------------------------       NOV13g   HHRNFLNTGCP-------------------------------------------------       NOV13h   SEAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQ-------PDVLKNIITEIIHSILLP       NOV13i   HHRNFLNTGCP-------------------------------------------------       NOV13j   SEAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQ-------PDVLKNIITEIIHSILLP       NOV13k   SEAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQ-------PDVLKNIITEIIHSILLP       NOV13l   SEAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQ-------PDVLKNIITEIIHSILLP               NOV13a   NQNGKLRSGVPVSLVKALGFEAAESSLTKDALVLTPASLWKPSSPVSQ       NOV13b   NQNGKLRSGVPVSLVKALGFEAAESSLSKDALVLTPASLWKPTSPVSQ       NOV13c   NQNGKLRSGVPVSLVKALGFEAAESSLSKDALVLTPASLWKPTSPVSQ       NOV13d   ------------------------------------------------       NOV13e   ------------------------------------------------       NOV13f   ------------------------------------------------       NOV13g   ------------------------------------------------       NOV13h   NQNGKLRSGVPVSLVKALGFEAAESSLTKDALVLTPASLWKPSSPVSQ       NOV13i   ------------------------------------------------       NOV13j   NQNGKLRSGVPVSLVKALGFEAAESSLTKDALVLTPASLWKPSSPVSQ       NOV13k   NQNGKLRSGVPVSLVKALGFEAAESSLTKDALVLTPASLWKPSSPVSQ       NOV13l   NQNGKLRSGVPVSLVKALGFEAAESSLSKDALVLTPASLWKPTSPVSQ               NOV13a   (SEQ ID NO: 370)       NOV13b   (SEQ ID NO: 372)       NOV13c   (SEQ ID NO: 374)       NOV13d   (SEQ ID NO: 376)       NOV13e   (SEQ ID NO: 378)       NOV13f   (SEQ ID NO: 380)       NOV13g   (SEQ ID NO: 382)       NOV13h   (SEQ ID NO: 384)       NOV13i   (SEQ ID NO: 386)       NOV13j   (SEQ ID NO: 388)       NOV13k   (SEQ ID NO: 390)       NOV13l   (SEQ ID NO: 392)                  
 
      Further analysis of the NOV13a protein yielded the following properties shown in Table 13C.  
               TABLE 13C                       Protein Sequence Properties NOV13a                                        SignalP analysis:   Cleavage site between residues 52 and 53       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 10; pos. chg 2; neg. chg 3           H-region:   length 2; peak value 0.00           PSG score:   −4.40                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 1.17           possible cleavage site: between 48 and 49                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 2           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 34-50               −2.71                             PERIPHERAL   Likelihood = 1.16 (at 200)                         ALOM score: −2.71 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 41           Charge difference: −0.5 C(1.5)-N(2.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 2 (cytoplasmic tail 1 to 34)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   8.50           Hyd Moment(95):   5.94   G content:   1           D/E content:   2   S/T content:   0                         Score: −7.21       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 8.3%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: MGVEDSQ       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 76.7       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         30.4%: mitochondrial           26.1%: cytoplasmic           17.4%: Golgi            8.7%: endoplasmic reticulum            4.3%: vacuolar            4.3%: extracellular, including cell wall            4.3%: nuclear            4.3%: vesicles of secretory system                 &gt;&gt; prediction for CG51622-04 is mit (k = 23)                  
 
      A search of the NOV13a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 13D.  
               TABLE 13D                          Geneseq Results for NOV13a                                         NOV13a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               AAY77126   Human neurotransmission-associated   28 . . . 518   484/491 (98%)   0.0           protein (NTAP) 2799056 -  Homo      1 . . . 484   484/491 (98%)             sapiens , 484 aa. [WO200001821-A2,           13-JAN-2000]       AAG63976   Amino acid sequence of a human   28 . . . 518   483/491 (98%)   0.0           Lng103 polypeptide -  Homo sapiens ,    1 . . . 484   484/491 (98%)           484 aa. [WO200161055-A2, 23-AUG-           2001]       ABU58539   Human PRO polypeptide #140 -  Homo     28 . . . 518   483/491 (98%)   0.0             sapiens , 484 aa. [US2003027272-A1,    1 . . . 484   484/491 (98%)           06-FEB-2003]       ABU57070   Human PRO polypeptide #140 -  Homo     28 . . . 518   483/491 (98%)   0.0             sapiens , 484 aa. [US2003027280-A1,    1 . . . 484   484/491 (98%)           06-FEB-2003]       ABU56075   Human secreted/transmembrane   28 . . . 518   483/491 (98%)   0.0           protein, PRO1357 -  Homo sapiens , 484    1 . . . 484   484/491 (98%)           aa. [US2003022298-A1, 30-JAN-2003]                  
 
      In a BLAST search of public sequence databases, the NOV13a protein was found to have homology to the proteins shown in the BLASTP data in Table 13E.  
               TABLE 13E                          Public BLASTP Results for NOV13a                                         NOV13a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q8TDL5   Von Ebner minor protein -  Homo     28 . . . 518    484/491 (98%)   0.0             sapiens  (Human), 484 aa.   1 . . . 484   484/491 (98%)       Q96HK6   Similar to DNA segment, Chr 2,   28 . . . 518    481/491 (97%)   0.0           Massachusetts Institute of Technology   1 . . . 484   484/491 (97%)           19 -  Homo sapiens  (Human), 484 aa.       Q9BWZ6   DJ1187J4.1.1 (Novel protein similar to   227 . . . 518    285/292 (97%)   e−154           mouse von Ebner salivary gland   1 . . . 285   285/292 (97%)           protein, isoform 1.) -  Homo sapiens             (Human), 285 aa (fragment).       CAD13090   Sequence 15 from Patent WO0174851 -   28 . . . 337    276/310 (89%)   e−146             Homo sapiens  (Human), 318 aa.   1 . . . 294   278/310 (89%)       Q8SPF8   Von Ebner minor salivary gland protein-   28 . . . 508    269/481 (55%)   e−144           like protein - Bos taurus (Bovine), 473 aa.   1 . . . 472   353/481 (72%)                  
 
      PFam analysis predicts that the NOV13a protein contains the domains shown in the Table 13F.  
               TABLE 13F                       Domain Analysis of NOV13a                                                        Pfam   NOV13a   Identities/   Expect           Domain   Match Region   Similarities   Value                   for the                   Matched Region                      
 
     Example 14.  
      The NOV14 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 14A.  
               TABLE 14A                       NOV14 Sequence Analysis                                                NOV14a, CG51821-01   SEQ ID NO: 397   5103 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 5101                       ATG GGCTTCTTGCCCAAGCTTCTCCTCCTGGCCTCAGCCGTTCTTCCCCCAGGCCAGGCCTCATGGGG           CGTCTCCAGTCCCCAGGACGTGCAGGGTGTGAAGGGGTCTTGCCTGCTTATCCCCTGCATCTTCAGCT       TCCCTGCCGACGTGGAGGTGCCCGACGGCATCACGGCCATCTGGTACTACGACTACTCGGGCCAGCGG       CAGGTGGTGAGCCACTCGGCGGACCCCAAGCTGGTGGAGGCCCGCTTCCGCGGCCGCACCGAGTTCAT       ACAACTTCCGCTTCGAGATCAGTGAGGTCAACCGCTGGTCAGATGTGAAAGGCACCTTGGTCACAGTA       ACAGGTGATCCCAGGGTGCCCACCATTGCCTCCCCGGTGGAGCTTCTCGAGGGCACAGAGGTGGACTT       CAACTGCTCCACTCCCTACGTATGCCTGCAGGAGCAGGTCAGACTGCAGTGGCAAGGCCAGGACCCTG       CTCGCTCTGTCACCTTCAACAGCCAGAAGTTTGAGCCCACCGGCGTCGGCCACCTGGAGACCCTCCAC       ATGGCCATGTCCTGGCAGGACCACGGCCGGATCCTGCGCTGCCAGCTCTCCGTGGCCAATCACAGGGC       TCAGAACGAGATTCACCTCCAAGTGAAGTGTGCCCCCAAGGGTGTGAAGATCCTCCTCAGCCCCTCGG       GGAGGAACATCCTTCCAGGTGAGCTGGTCACACTCACCTGCCAGGTGAACAGCAGCTACCCTGCAGTC       AGTTCCATTAAGTGGCTCAAGGATGGGGTACGCCTCCAAACCAAGACTGGTGTGCTGCACCTGCCCCA       GGCAGCCTGGAGCGATGCTGGCGTCTACACCTGCCAAGCTGAGAACGGCGTGGGCTCTTTGGTCTCAC       CCCCCATCAGCCTCCACATCTTCGTGGCTGAGGTCCAGGTGAGCCCAGCAGGTCCCATCCTGGAGAAC       CAGACAGTGACACTAGTCTGCAACACACCCAATGAGGCACCCAGTGATCTCCGCTACAGCTGGTACAA       GAACCATGTCCTGCTGGAGGATGCCCACTCCCATACCCTCCGGCTGCACTTGGCCACTAGGGCTGATA       CTGGCTTCTACTTCTGTGAGGTGCAGAACGTCCATGGCAGCGAGCGCTCGGGCCCTGTCAGCGTGGTA       GTCACAGACCCGCCTCTCACTCCAGTCCTGACAGCCTTCCTGGAGACCCAGGCGGGACTTGTGGGCAT       CCTTCACTGCTCTGTGGTCAGTGAGCCCCTGGCCACACTGGTGCTGTCACATGGGGGTCATATCCTGG       CCTCCACCTCCGGGGACAGTGATCACAGCCCACGCTTCAGTGGTACCTCTGGTCCCAACTCCCTGCGC       CTGGAGATCCGAGACCTGGAGGAAACTGACAGTGGGGAGTACAAGTGCTCAGCCACCAACTCCCTTGG       AAATGCAACCTCCACCCTGGACTTCCATGCCAATGTCGCCCGTCTCCTCATCAGCCCGGCAGCCGAGG       TGGTGGAAGGACAGGCAGTGACACTGAGCTGCAGAAGCGGCCTAAGCCCCACACCTGATGCCCGCTTC       TCCTGGTACCTGAATGGAGCCCTGCTTCACGAGGGTCCCGGCAGCAGCCTCCTGCTCCCCGCGGCCTC       CAGCACTGACGCCGGCTCATACCACTGCCGGGCCCGGGACGGCCACAGTGCCAGTGGCCCCTCTTCGC       CAGCTGTTCTCACTGTGCTCTGTGAGCAGCCACCACGACAACCAACATTCACCACCAGGCTGGACCTT       GATGCCGCTGGGGCCGGGGCTGGACGGCGAGGCCTCCTTTTGTGCCGTGTGGACAGCGACCCCCCCGC       CAGGCTGCAGCTGCTCCACAAGGACCGTGTTGTGGCCACTTCCCTGCCATCAGGGGGTGGCTGCAGCA       CCTGTGGGGGCTGTTCCCCACGCATGAAGGTCACCAAAGCCCCCAACTTGCTGCGTGTGGAGATTCAC       AACCCTTTGCTGGAAGAGGAGGGCTTGTACCTCTGTGAGGCCAGCAATGCCCTGGGCAACGCCTCCAC       CTCAGCCACCTTCAATGGCCAGGCCACTGTCCTGGCCATTGCACCATCACACACACTTCAGGAGGGCA       AGAAGCACAACTTGACTTGCAACGTGAGCCGGGAAGCTGCTGGCAGCCCTGCTAACTTCTCCTGGTTC       CGAAATGGGGTGCTGTGGGCCCAGGGTCCCCTGGAGACCGTGACACTGCTGCCCGTGGCCAGAACTGA       TGCTGCCCTTTACGCCTGCCGCATCCTGACTGAGGCTGGTGCCCAGCTCTCCACTCCCGTGCTCCTGA       GTGTACTCTATCCCCCGGACCGTCCAAAGCTGTCAGCCCTCCTAGACATGGGCCAGGGCCACATGGCT       CTGTTCATCTGCACTGTGGACAGCCGCCCCCTGGCCTTGCTGGCCTTGTTCCATGGGGAGCACCTCCT       GGCCACCAGCCTGGGTCCCCAGGTCCCATCCCATGGTCGGTTCCAGGCTAAAGCTGAGGCCAACTCCC       TGAAGTTAGAGGTCCGAGAACTGGGCCTTGGGGACTCTGGCAGCTACCGCTGTGAGGCCACAAATGTT       TGAGCTCCAAGAGGGCCAGGCTGTGGTCCTGAGCTGCCAGGTACACACAGGAGTCCCAGAGGGGACCT       CATATCGTTGGTATCGGGATGGCCAGCCCCTCCAGGAGTCGACCTCGGCCACGCTCCGCTTTGCAGCC       AGCTGCACCCATCAGCCTCCACGTGTCCTGTAAGGATGCCCCACGCCACGTCACACTCACTACCCTGA       TGGACACAGGCCCTGGACGACTGGGCCTCCTCCTGTGCCGTGTGGACAGTGACCCTCCGGCCCAGCTG       TCCCAGGCTGCATGTGGCTGTGGCCCCCAACACACTGCGTCTGGAGATCCACGGGGCTATGCTGGAGG       ATGAGGGTGTCTATATCTGTGAGGCCTCCAACACCCTGGGCCAGGCCTCGGCCTCAGCTGACTTCGAC       GCTCAAAGCTGTGAATGTGCAGGTGTGGCCCGGGGCTACCGTGCGGGAGGGGCAGCTGGTGAACCTGA       CCTGCGCCTGACCTACCTCCTGGAGAGCCATGGCGGGCAGCTGGCCCTGGTACTGTGCACTGTGGACA       GCCGCCCGCCCGCCCAGCTGGCCCTCAGCCACGCCGGTCGCCTCTTGGCCTCCTCGACAGCAGCCTCT       GTCCCCAACACCCTGCGCCTGGAGCTGCGAGGGCCACAGCCCAGGGATGAGGGTTTCTACAGCTGCTC       TGCCCGCAGCCCTCTGGGCCAGGCCAACACGTCCCTGGAGCTGCGGCTGGAGGTGCGGGTGATCCTGG       CTCCGGAGGCTGCCGTGCCTGAAGGTGCCCCCATCACAGTGACCTGTGCGGACCCTGCTGCCCACGCA       CCCACACTCTATACTTGGTACCACAACGGTCGTTGGCTGCAGGAGGGTCCAGCTGCCTCACTCTCATT       CCTGGTGGCCACGCGGGCTCATGCAGGCGCCTACTCTTGCCAGGCCCAGGATGCCCAGGGCACCCGCA       GCTCCCGTCCTGCTGCCCTGCAAGTCCTCTGTGCCCCTCAGGACGCTGTCCTGTCCTCCTTCCGGGAC       TCCAGGGCCAGATCCATGGCTGTGATACAGTGCACTGTGGACAGTGAGCCACCTGCTGAGCTGGCCCT       ATCTCATGATGGCAAGGTGCTGGCCACGAGCAGCGGGGTCCACAGCTTGGCATCAGGGACAGGCCATG       TCCAGGTGGCCCGAAACGCCCTACGGCTGCAGGTGCAAGATGTGCCTGCAGGTGATGACACCTATGTT       TGCACAGCCCAAAACTTGCTGGGCTCAATCAGCACCATCGGGCGGTTGCAGGTAGAAGGTGAGTGGCG       CGTGGTGGCAGAGCCTGGCCTGGACGTGCCTGAGGGCGCTGCCCTGAACCTCAGCTGCCGCCTCCTGG       GTGGCCCTGGGCCTGTGGGCAACTCCACCTTTGCATGGTTCTGGAATGACCGGCGGCTGCACGCGGAG       CCTGTGCCCACTCTCGCCTTCACCCACGTGGCTCGTGCTCAAGCTGGGATGTACCACTGCCTGGCTGA       GCTCCCCACTGGGGCTGCTGCCTCTGCTCCAGTCATGCTCCGTGTGCTCTACCCTCCCAAGACGCCCA       CCATGATGGTCTTCGTGGAGCCTGAGGGTGGCCTCCGGGGCATCCTGGATTGCCGAGTGGACAGCGAG       CCGCTCGCCAGCCTGACTCTCCACCTTGGCAGTCGACTGGTGGCCTCCAGTCAGCCCCAGGGTGCTCC       TGCAGAGCCACACATCCATGTCCTGGCTTCCCCCAATGCCCTGAGGGTGGACATCGAGGCGCTGAGGC       CCAGCGACCAAGGGGAATACATCTGTTCTGCCTCAAATGTCCTGGGCCCTGCCTCTACCTCCACCTAC       TTTGGGGTCAGAGCCCTGCACCGCCTGCATCAGTTCCAGCAGCTGCTCTGGGTCCTGGGACTGCTGGT       GGGCCTCCTGCTCCTGCTGTTGGGCCTGGGGGCCTGCTACACCTGGAGAAGGAGGCGTGTTTGTAAGC       AGAGCATGGGCGAGAATCCAGGGCGGGCATCGTCTTTCCATTTACTGCCTCTAGCTGGGTCTTCAAGG         TGA                                           NOV14a, CG51821-01                       Protein Sequence   SEQ ID NO: 398   1700 aa   MW at 180833.0kD                     MGFLPKLLLLASAVLPPGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQR           QVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTV       TGDPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLH       MAMSWQDHGRILRCQLSVANHRAQSEIHLQVKCAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAV       SSIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFVAEVQVSPAGPILEN       QTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVV       VTDPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLR       LEIRDLEETDSGEYKCSATNSLGNATSTLDFHAIVARLLISPAAEVVEGQAVTLSCRSGLSPTPDARF       SWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLCEQPPRQPTFTTRLDL       DAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIH       NPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWF       RNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMA       LFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNV       LGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAA       ITLTQAGAYHCQAQAPGSATTSLAAPISLHVSCKDAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL       RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFD       AQSCECAGVARGYRAGGAAGEPDLPCVDHSPGPAHLHMVPGWAAAPGCPLHPPAQRHSQGCHLLPLRC       GPPWSGTPPLQTYHLGRPHAPRNLRLTYLLESHGGQLALvLCTVDSRPPAQLALSHAGRLLASSTAAS       VPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEVRVILAPEAAVPEGAPITVTCADPAAHA       PTLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLCAPQDAVLSSFRD       SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYV       CTAQNLLGSISTIAGRLQVEGEWRWAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAE       PVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSE       PLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGPASTSTY       FGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENPGRASSFHLLPLAGSSR                                     NOV14b, 229823091   SEQ ID NO: 399   717 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     AGATCTTCATGGGGCGTCTCCAGTCCCCAGGACGTGCAGGGTGTGAAGGGGTCTTGCCTGCTTATCCC           CTGCATCTTCAGCTTCCCTGCCGACGTGGAGGTGCCCGACGGCATCACGGCCATCTGGTACTACGACT       ACTCGGGCCAGCGGCAGGTGGTGAGCCACTCGGCGGACCCCAAGCTGGTGGAGGCCCGCTTCCGCGGC       CGCACCGAGTTCATGGGGAACCCCGAGCACAGGGTGTGCAACCTGCTGCTGAAGGACCTGCAGCCCGA       GGACTCTGGTTCCTACAACTTCCGCTTCGAGATCAGTGAGGTCAACCGCTGGTCAGATGTGAAAGGCA       CCTTGGTCACAGTAACAGAGGAGCCCAGGGTGCCCACCATTGCCTCCCCGGTGGAGCTTCTCGAGGGC       ACAGAGGTGGACTTCAACTGCTCCACTCCCTACGTATGCCTGCAGGAGCAGGTCAGACTGCAGTGGCA       AGGCCAGGACCCTGCTCGCTCTGTCACCTTCAACAGCCAGAAGTTTGAGCCCACCGGCGTCGGCCACC       TGGAGACCCTCCACATGGCCATGTCCTGGCAGGACCACGGCCGGATCCTGCGCTGCCAGCTCTCCGTG       GCCAATCACAGGGCTCAGAGCGAGATTCACCTCCAAGTGAAGTATGCCCCCAGGGGTGTGAAGATCCT       CCTCAGCCCCTCGGGGAGGAACATCCTTCCAGTCGAC                                         NOV14b, 229823091                       Protein Sequence   SEQ ID NO: 400   239 aa   Mw at 26882.1kD                     RSSWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARFRG           RTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEG       TEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV       ANHRAQSEIHLQVKYAPRGVKILLSPSGRNILPVD                                     NOV14c, 229823107   SEQ ID NO: 401   717 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     AGATCTTCATGGGGCGTCTCCAGTCCCCAGGACGTGCAGGGTGTGAAGGGGTCTTGCCTGCTTATCCC           CTGCATCTTCAGCTTCCCTGCCGACGTGGAGGTGCCCGACGGCATCACGGCCATCTGGTACTACGACT       ACTCGGGCCAGCGGCAGGTGGTGAGCCACTCGGCGGACCCCAAGCTGGTGGAGGCCCGCTTCCGCGGC       CGCACCGAGTTCATGGGGAACCCCGAGCACAGGGTGTGCAACCTGCTGCTGAAGGACCTGCAGCCCGA       GGACTCTGGTTCCTACAACTTCCGCTTCGAGATCAGTGAGGTCAACCGCTGGTCAGATGTGAAAGGCA       CCTTGGTCACAGTAACAGAGGAGCCCAGGGTGCCCACCATTGCCTCCCCGGTGGAGCTTCTCGAGGGC       ACAGAGGTGGACTTCAACTGCTCCACTCCCTACGTATGCCTGCAGGAGCAGGTCAGACTGCAGTGGCA       AGGCCAGGACCCTGCTCGCTCTGTCACCTTCAACAGCCAGAAGTTTGAGCCCACCGGCGTCGGCCACC       TGGAGACCCTCCACATGGCCATGTCCTGGCAGGACCACGGCCGGATCCTGCGCTGCCAGCTCTCCATG       GCCAATCACAGGGCTCAGAGCGAGATTCACCTCCAAGTGAAGTATGCCCCCAGGGGTGTGAAGATCCT       CCTCAGCCCCTCGGGGAGGAACATCCTTCCAGTCGAC                                         NOV14c, 229823107                       Protein Sequence   SEQ ID NO: 402   239 aa   MW at 26914.2kD                     RSSWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARFRG           RTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFETSEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEG       TEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSM       ANHRAQSEIHLQVKYAPRGVKILLSPSGRNILPVD                                     NOV14d, 229823095   SEQ ID NO: 403   717 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     AGATCTTCATGGGGCGTCTCCAGTCCCCAGGACGTGCAGGGTGTGAAGGGGTCTTGCCTGCTTATCCC           CTGCATCTTCAGCTTCCCTGCCGACGTGGAGGTGCCCGACGGCATCACGGCCATCTGGTACTACGACT       ACTCGGGCCAGCGGCAGGTGGTGAGCCACTCGGTGGACCCCAAGCTGGTGGAGGCCCGCTTCCGCGGC       CGCACCGAGTTCATGGGGAACCCCGAGCACAGGGTGTGCAACCTGCTGCTGAAGGACCTGCAGCCCGA       GGACTCTGGTTCCTACAACTTCCGCTTCGAGATCAGTGAGGTCAACCGCTGGTCAGATGTGAAAGGCA       CCTTGGTCACAGTAACAGAGGAGCCCAGGGTGCCCACCATTGCCTCCCCGGTGGAGCTTCTCGAGGGC       ACAGAGGTGGACTTCAACTGCTCCACTCCCTACGTATGCCTGCAGGAGCAGGTCAGACTGCAGTGGCA       AGGCCAGGACCCTGCTCGCTCTGTCACCTTCAACAGCCAGAAGTTTGAGCCCACCGGCGTCGGCCACC       TGGAGACCCTCCACATGGCCATGTCCTGGCAGGACCACGGCCGGATCCTGCGCTGCCAGCTCTCCATG       GCCAATCACAGGGCTCAGAGCGAGATTCACCTCCAAGTGAAGTATGCCCCCAAGGGTGTGAAGATCCT       CCTCAGCCCCTCGGGGAGGAACATCCTTCCAGTCGAC                                         NOV14d, 229823095                       Protein Sequence   SEQ ID NO: 404   239 aa   Mw at 26914.2kD                     RSSWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSVDPKLVEARFRG           RTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEG       TEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSM       ANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPVD                                     NOV14e, CG51821-02   SEQ ID NO: 405   717 bp           DNA Sequence   ORF Start: at 7   ORF Stop: at 712                       AGATCT TCATGGGGCGTCTCCAGTCCCCAGGACGTGCAGGGTGTGAAGGGGTCTTGCCTGCTTATCCC           CTGCATCTTCAGCTTCCCTGCCGACGTGGAGGTGCCCGACGGCATCACGGCCATCTGGTACTACGACT       ACTCGGGCCAGCGGCAGGTGGTGAGCCACTCGGCGGACCCCAAGCTGGTGGAGGCCCGCTTCCGCGGC       CGCACCGAGTTCATGGGGAACCCCGAGCACAGGGTGTGCAACCTGCTGCTGAAGGACCTGCAGCCCGA       GGACTCTGGTTCCTACAACTTCCGCTTCGAGATCAGTGAGGTCAACCGCTGGTCAGATGTGAAAGGCA       CCTTGGTCACAGTAACAGAGGAGCCCAGGGTGCCCACCATTGCCTCCCCGGTGGAGCTTCTCGAGGGC       ACAGAGGTGGACTTCAACTGCTCCACTCCCTACGTATGCCTGCAGGAGCAGGTCAGACTGCAGTGGCA       AGGCCAGGACCCTGCTCGCTCTGTCACCTTCAACAGCCAGAAGTTTGAGCCCACCGGCGTCGGCCACC       TGGAGACCCTCCACATGGCCATGTCCTGGCAGGACCACGGCCGGATCCTGCGCTGCCAGCTCTCCGTG       GCCAATCACAGGGCTCAGAGCGAGATTCACCTCCAAGTGAAGTATGCCCCCAGGGGTGTGAAGATCCT       CCTCAGCCCCTCGGGGAGGAACATCCTTCCAGTC GAC                                           NOV14e, CG51821 -02                       Protein Sequence   SEQ ID NO: 406   235 aa   MW at 26424.7kD                     SWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPKLVEARFRGRT           EFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTE       VDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVAN       HRAQSEIHLQVKYAPRGVKILLSPSGRNILP                                     NOV14f, CG51821-03   SEQ ID NO: 407   717 bp           DNA Sequence   ORF Start: at 7   ORF Stop: at 712                       AGATCT TCATGGGGCGTCTCCAGTCCCCAGGACGTGCAGGGTGTGAAGGGGTCTTGCCTGCTTATCCC           CTGCATCTTCAGCTTCCCTGCCGACGTGGAGGTGCCCGACGGCATCACGGCCATCTGGTACTACGACT       CGCACCGAGTTCATGGGGAACCCCGAGCACAGGGTGTGCAACCTGCTGCTGAAGGACCTGCAGCCCGA       CCTTGGTCACAGTAACAGAGGAGCCCAGGGTGCCCACCATTGCCTCCCCGGTGGAGCTTCTCGAGGGC       ACAGAGGTGGACTTCAACTGCTCCACTCCCTACGTATGCCTGCAGGAGCAGGTCAGACTGCAGTGGCA       AGGCCAGGACCCTGCTCGCTCTGTCACCTTCAACAGCCAGAAGTTTGAGCCCACCGGCGTCGGCCACC       TGGAGACCCTCCACATGGCCATGTCCTGGCAGGACCACGGCCGGATCCTGCGCTGCCAGCTCTCCATG       CCTCAGCCCCTCGGGGAGGAACATCCTTCCAGTC GAC                                           NOV14f, CG51821-03                       Protein Sequence   SEQ ID NO: 408   235 aa   MW at 26456.8kD                     SWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSVDPKLVEARFRGRT           EFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTE       VDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSMAN       HRAQSEIHLQVKYAPKGVKILLSPSGRNILP                                     NOV14g, CG51821-04   SEQ ID NO: 409   5130 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 5128                       ATG GGCTTCTTGCCCAAGCTTCTCCTCCTGGCCTCATTCTTCCCAGCAGGCCAGGCCTCATGGGGCGT           CTCCAGTCCCCAGGACGTGCAGGGTGTGAAGGGGTCTTGCCTGCTTATCCCCTGCATCTTCAGCTTCC       CTGCCGACGTGGAGGTGCCCGACGGCATCACGGCCATCTGGTACTACGACTACTCGGGCCAGCGGCAG       GTGGTGAGCCACTCGGCGGACCCCAAGCTGGTGGAGGCCCGCTTCCGCGGCCGCACCGAGTTCATGGG       GAACCCCGAGCACAGGGTGTGCAACCTGCTGCTGAAGGACCTGCAGCCCGAGGACTCTGGTTCCTACA       ACTTCCGCTTCGAAATCAGTGAGGTCAACCGCTGGTCAGATGTGAAAGGCACCTTGGTCACAGTAACA       GAGGAGCCCAGGGTGCCCACCATTGCCTCCCCGGTGGAGCTTCTCGAGGGCACAGAGGTGGACTTCAA       CTGCTCCACTCCCTACGTATGCCTGCAGGAGCAGGTCAGACTGCAGTGGCAAGGCCAGGACCCTGCTC       GCTCTGTCACCTTCAACAGCCAGAAGTTTGAGCCCACCGGCGTCGGCCACCTGGAGACCCTCCACATG       GCCATGTCCTGGCAGGACCACGGCCGGATCCTGCGCTGCCAGCTCTCCGTGGCCAATCACAGGGCTCA       GAGCGAGATTCACCTCCAAGTGAAGTATGCCCCCAAGGGTGTGAAGATCCTCCTCAGCCCCTCGGGGA       GGAACATCCTTCCAGGTGAGCTGGTCACACTCACCTGCCAGGTGAACAGCAGCTACCCTGCAGTCACT       TCCATTAAGTGGCTCAAGGATGGGGTACGCCTCCAAACCAAGACTGGTGTGCTGCACCTGCCCCAGGC       AGCCTGGAGCGATGCTGGCGTCTACACCTGCCAAGCTGAGAACGGCGTGGGCTCTTTGGTCTCACCCC       CCATCAGCCTCCACATCTTCATGGCTGAGGTCCAGGTGAGCCCAGCAGGTCCCATCCTGGAGAACCAG       ACAGTGACACTAGTCTGCAACACACCCAATGAGGCACCCAGTGATCTCCGCTACAGCTGGTACAAGAA       CCATGTCCTGCTGGAGGATGCCCACTCCCATACCCTCCGGCTGCACTTGGCCACTAGGGCTGATACTG       GCTTCTACTTCTGTGAGGTGCAGAACGTCCATGGCAGCGAGCGCTCGGGCCCTGTCAGCGTGGTAGTC       AACCACCCGCCTCTCACTCCAGTCCTGACAGCCTTCCTGGAGACCCAGGCGGGACTTGTGGGCATCCT       TCACTGCTCTGTGGTCAGTGAGCCCCTGGCCACACTGGTGCTGTCACATGGGGGTCATATCCTGGCCT       CCACCTCCGGGGACAGTGATCACAGCCCACGCTTCAGTGGTACCTCTGGTCCCAACTCCCTGCGCCTG       GAGATCCGAGACCTGGAGGAAACTGACAGTGGGGAGTACAAGTGCTCAGCCACCAACTCCCTTGGAAA       TGCAACCTCCACCCTGGACTTCCATGCCAATGCCGCCCGTCTCCTCATCAGCCCGGCAGCCGAGGTGG       TGGAAGGACAGGCAGTGACACTGAGCTGCAGAAGCGGCCTAAGCCCCACACCTGATGCCCGCTTCTCC       TGGTACCTGAATGGAGCCCTGCTTCACGAGGGTCCCGGCAGCAGCCTCCTGCTCCCCGCGGCCTCCAG       CACTGACGCCGGCTCATACCACTGCCGGGCCCGGGACGGCCACAGTGCCAGTGGCCCCTCTTCGCCAG       GGGGCCGGGGCTGGACGGCGAGGCCTCCTTTTGTGCCGTGTGGACAGCGACCCCCCCGCCAGGCTGCA       GCTGCTCCACAAGGACCGTGTTGTGGCCACTTCCCTGCCATCAGGGGGTGGCTGCAGCACCTGTGGGG       GCTGTTCCCCACGCATGAAGGTCACCAAAGCCCCCAACTTGCTGCGTGTGGAGATTCACAACCCTTTG       CTGGAAGAGGAGGGCTTGTACCTCTGTGAGGCCAGCAATGCCCTGGGCAACGCCTCCACCTCAGCCAC       CTTCAATGGCCAGGCCACTGTCCTGGCCATTGCACCATCACACACACTTCAGGAGGGCACAGAAGCCA       ACTTGACTTGCAACGTGAGCCGGGAAGCTGCTGGCAGCCCTGCTAACTTCTCCTGGTTCCGAAATGGG       GTGCTGTGGGCCCAGGGTCCCCTGGAGACCGTGACACTGCTGCCCGTGGCCAGAACTGATGCTGCCCT       TTACGCCTGCCGCATCCTGACTGAGGCTGGTGCCCAGCTCTCCACTCCCGTGCTCCTGAGTGTACTCT       ATCCCCCGGACCGTCCAAAGCTGTCAGCCCTCCTAGACATGGGCCAGGGCCACATGGCTCTGTTCATC       TGCACTGTGGACAGCCGCCCCCTGGCCTTGCTGGCCTTGTTCCATGGGGAGCACCTCCTGGCCACCAG       CCTGGGTCCCCAGGTCCCATCCCATGGTCGGTTCCAGGCTAAAGCTGAGGCCAACTCCCTGAAGTTAG       AGGTCCGAGAACTGGGCCTTGGGGACTCTGGCAGCTACCGCTGTGAGGCCACAAATGTTCTTGGATCA       TCCAACACCTCACTCTTCTTCCAGGTCCGAGGAGCCTGGGTCCAGGTGTCACCATCACCTGAGCTCCA       AGAGGGCCAGGCTGTGGTCCTGAGCTGCCAGGTACACACAGGAGTCCCAGAGGGGACCTCATATCGTT       GGTATCGGGATGGCCAGCCCCTCCAGGAGTCGACCTCGGCCACGCTCCGCTTTGCAGCCATAACTTTG       ACACAAGCTGGGGCCTATCATTGCCAAGCCCAGGCCCCAGGCTCAGCCACCACGAGCCTAGCTGCACC       CATCAGCCTCCACGTGTCCTATGCCCCACGCCACGTCACACTCACTACCCTGATGGACACAGGCCCTG       GACGACTGGGCCTCCTCCTGTGCCGTGTGGACAGTGACCCTCCGGCCCAGCTGCGGCTGCTCCACGGG       GATCGCCTTGTGGCCTCCACCCTACAAGGTGTGGGGGGACCCGAAGGCAGCTCTCCCAGGCTGCATGT       GGCTGTGGCCCCCAACACACTGCGTCTGGAGATCCACGGGGCTATGCTGGAGGATGAGGGTGTCTATA       TCTGTGAGGCCTCCAACACCCTGGGCCAGGCCTCGGCCTCAGCTGACTTCGACGCTCAAGCTGTGAAT       GTGCAGGTGTGGCCCGGGGCTACCGTGCGGGAGGGGCAGCTGGTGAACCTGACCTGCCTTGTGTGGAC       CACTCACCCGGCCCAGCTCACCTACACATGGTACCAGGATGGGCAGCAGCGCCTGGATGCCCACTCCA       GCACCCCGCCTCTCCAGACCTATCACCTTGGACGTCCTCTACGCGCCCCGCAACCTGCGCCTGACCTA       CCTCCTGGAGAGCCATGGCGGGCAGCTGGCCCTGGTACTGTGCACTGTGGACAGCCGCCCGCCCGCCC       AGCTGGCCCTCAGCCACGCCGGTCGCCTCTTGGCCTCCTCGACAGCAGCCTCTGTCCCCAACACCCTG       CGCCTGGAGCTGCGAGGGCCACAGCCCAGGGATGAGGGTTTCTACAGCTGCTCTGCCCGCAGCCCTCT       GGGCCAGGCCAACACGTCCCTGGAGCTGCGGCTGGAGGGTGTGCGGGTGATCCTGGCTCCGGAGGCTG       CCGTGCCTGAAGGTGCCCCCATCACAGTGACCTGTGCGGACCCTGCTGCCCACGCACCCACACTCTAT       ACTTGGTACCACAACGGTCGTTGGCTGCAGGAGGGTCCAGCTGCCTCACTCTCATTCCTGGTGGCCAC       GCGGGCTCATGCAGGCGCCTACTCTTGCCAGGCCCAGGATGCCCAGGGCACCCGCAGCTCCCGTCCTG       CTGCCCTGCAAGTCCTCTATGCCCCTCAGGACACTGTCCTGTCCTCCTTCCGGGACTCCAGGGCCAGA       TCCATGGCTGTGATACAGTGCACTGTGGACAGTGAGCCACCTGCTGAGCTGGCCCTATCTCATGATGG       CAAGGTGCTGGCCACGAGCAGCGGGGTCCACAGCTTGGCATCAGGGACAGGCCATGTCCAGGTGGCCC       GAAACGCCCTACGGCTGCAGGTGCAAGATGTGCCTGCAGGTGATGACACCTATGTTTGCACAGCCCAA       AACTTGCTGGGCTCAATCAGCACCATCGGGCGGTTGCAGGTAGAAGGTGCACGCGTGGTGGCAGAGCC       TGGGCAACTCCACCTTTGCATGGTTCTGGAATGACCGGCGGCTGCACGCGGAGCCTGTGCCCACTCTC       GCCTTCACCCACGTGGCTCGTGCTCAAGCTGGGATGTACCACTGCCTGGCTGAGCTCCCCACTGGGGC       TGCTGCCTCTGCTCCAGTCATGCTCCGTGTGCTCTACCCTCCCAAGACGCCCACCATGATGGTCTTCG       TGGAGCCTGAGGGTGGCCTCCGGGGCATCCTGGATTGCCGAGTGGACAGCGAGCCGCTCGCCAGCCTG       ACTCTCCACCTTGGCAGTCGACTGGTGGCCTCCAGTCAGCCCCAGGGTGCTCCTGCAGAGCCACACAT       CCATGTCCTGGCTTCCCCCAATGCCCTGAGGGTGGACATCGAGGCGCTGAGGCCCAGCGACCAAGGGG       AATACATCTGTTCTGCCTCAAATGTCCTGGGCTCTGCCTCTACCTCCACCTACTTTGGGGTCAGAGCC       CTGCACCGCCTGCATCAGTTCCAGCAGCTGCTCTGGGTCCTGGGACTGCTGGTGGGCCTCCTGCTCCT       GCTGTTGGGCCTGGGGGCCTGCTACACCTGGAGAAGGAGGCGTGTTTGTAAGCAGAGCATGGGCGAGA       ATTCGGTGGAGATGGCTTTTCAGAAAGAGACCACGCAGCTCATTGATCCTGATGCAGCCACATGTGAG       ACCTCAACCTGTGCCCCACCCCTGGGC TGA                                           NOV14g, CG51821-04                       Protein Sequence   SEQ ID NO: 410   1709 aa   Mw at 182651.9kD                     MGFLPKLLLLASFFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQ           VVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVT       EEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLHM       AMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVS       SIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQ       TVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVV       NHPPLTPVLTAFLETQAGLVGILHCSVTSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRL       EIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPDARFS       WYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAA       GAGAGRRGLLLCRVDSDPPAPLQLLHKDRVVATSLPSGGGCSTCGGCSPRNKVTKAPNLLRVEIHNPL       LEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFRNG       VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFI       CTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGS       SNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITL       TQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHG       DRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVN       VQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGR       APRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTL       RLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPMMVTCADPAAHAPTLY       TWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDTVLSSFRDSPAR       SMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQ       NLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTL       AFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASL       TLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYFGVRA       LHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENSVEMAFQKETTQLIDPDAATCE       TSTCAPPLG                                     NOV14h,                   SNP1 3382490   SEQ ID NO: 411   5103 bp       of CG51821-01,   ORF Start: ATG at 1   ORF Stop: TGA at 5101       DNA Sequence   SNP Pos: 4056   SNP Change: C to T                       ATG GGCTTCTTGCCCAAGCTTCTCCTCCTGGCCTCAGCCGTTCTTCCCCCAGGCCAGGCCTCATGGGG           CGTCTCCAGTCCCCAGGACGTGCAGGGTGTGAAGGGGTCTTGCCTGCTTATCCCCTGCATCTTCAGCT       TCCCTGCCGACGTGGAGGTGCCCGACGGCATCACGGCCATCTGGTACTACGACTACTCGGGCCAGCGG       CAGGTGGTGAGCCACTCGGCGGACCCCAAGCTGGTGGAGGCCCGCTTCCGCGGCCGCACCGAGTTCAT       GGGGAACCCCGAGCACAGGGTGTGCAACCTGCTGCTGAAGGACCTGCAGCCCGAGGACTCTGGTTCCT       ACAACTTCCGCTTCGAGATCAGTGAGGTCAACCGCTGGTCAGATGTGAAAGGCACCTTGGTCACAGTA       ACAGGTGATCCCAGGGTGCCCACCATTGCCTCCCCGGTGGAGCTTCTCGAGGGCACAGAGGTGGACTT       CAACTGCTCCACTCCCTACGTATGCCTGCAGGAGCAGGTCAGACTGCAGTGGCAAGGCCAGGACCCTG       CTCGCTCTGTCACCTTCAACAGCCAGAAGTTTGAGCCCACCGGCGTCGGCCACCTGGAGACCCTCCAC       ATGGCCATGTCCTGGCAGGACCACGGCCGGATCCTGCGCTGCCAGCTCTCCGTGGCCAATCACAGGGC       TCAGAGCGAGATTCACCTCCAAGTGAAGTGTGCCCCCAAGGGTGTGAAGATCCTCCTCAGCCCCTCGG       GGAGGAACATCCTTCCAGGTGAGCTGGTCACACTCACCTGCCAGGTGAACAGCAGCTACCCTGCAGTC       GGCAGCCTGGAGCGATGCTGGCGTCTACACCTGCCAAGCTGAGAACGGCGTGGGCTCTTTGGTCTCAC       CCCCCATCAGCCTCCACATCTTCGTGGCTGAGGTCCAGGTGAGCCCAGCAGGTCCCATCCTGGAGAAC       CAGACAGTGACACTAGTCTGCAACACACCCAATGAGGCACCCAGTGATCTCCGCTACAGCTGGTACAA       GAACCATGTCCTGCTGGAGGATGCCCACTCCCATACCCTCCGGCTGCACTTGGCCACTAGGGCTGATA       CTGGCTTCTACTTCTGTGAGGTGCAGAACGTCCATGGCAGCGAGCGCTCGGGCCCTGTCAGCGTGGTA       GTCACAGACCCGCCTCTCACTCCAGTCCTGACAGCCTTCCTGGAGACCCAGGCGGGACTTGTGGGCAT       CCTTCACTGCTCTGTGGTCAGTGAGCCCCTGGCCACACTGGTGCTGTCACATGGGGGTCATATCCTGG       CCTCCACCTCCGGGGACAGTGATCACAGCCCACGCTTCAGTGGTACCTCTGGTCCCAACTCCCTGCGC       CTGGAGATCCGAGACCTGGAGGAAACTGACAGTGGGGAGTACAAGTGCTCAGCCACCAACTCCCTTGG       AAATGCAACCTCCACCCTGGACTTCCATGCCAATGTCGCCCGTCTCCTCATCAGCCCGGCAGCCGAGG       TGGTGGAAGGACAGGCAGTGACACTGAGCTGCAGAAGCGGCCTAAGCCCCACACCTGATGCCCGCTTC       TCCTGGTACCTGAATGGAGCCCTGCTTCACGAGGGTCCCGGCAGCAGCCTCCTGCTCCCCGCGGCCTC       CAGCACTGACGCCGGCTCATACCACTGCCGGGCCCGGGACGGCCACAGTGCCAGTGGCCCCTCTTCGC       CAGCTGTTCTCACTGTGCTCTGTGAGCAGCCACCACGACAACCAACATTCACCACCAGGCTGGACCTT       GATGCCGCTGGGGCCGGGGCTGGACGGCGAGGCCTCCTTTTGTGCCGTGTGGACAGCGACCCCCCCGC       CAGGCTGCAGCTGCTCCACAAGGACCGTGTTGTGGCCACTTCCCTGCCATCAGGGGGTGGCTGCAGCA       CCTGTGGGGGCTGTTCCCCACGCATGAAGGTCACCAAAGCCCCCAACTTGCTGCGTGTGGAGATTCAC       AACCCTTTGCTGGAAGAGGAGGGCTTGTACCTCTGTGAGGCCAGCAATGCCCTGGGCAACGCCTCCAC       CTCAGCCACCTTCAATGGCCAGGCCACTGTCCTGGCCATTGCACCATCACACACACTTCAGGAGGGCA       CAGAAGCCAACTTGACTTGCAACGTGAGCCGGGAAGCTGCTGGCAGCCCTGCTAACTTCTCCTGGTTC       CGAAATGGGGTGCTGTGGGCCCAGGGTCCCCTGGAGACCGTGACACTGCTGCCCGTGGCCAGAACTGA       TGCTGCCCTTTACGCCTGCCGCATCCTGACTGAGGCTGGTGCCCAGCTCTCCACTCCCGTGCTCCTGA       GTGTACTCTATCCCCCGGACCGTCCAAAGCTGTCAGCCCTCCTAGACATGGGCCAGGGCCACATGGCT       CTGTTCATCTGCACTGTGGACAGCCGCCCCCTGGCCTTGCTGGCCTTGTTCCATGGGGAGCACCTCCT       GGCCACCAGCCTGGGTCCCCAGGTCCCATCCCATGGTCGGTTCCAGGCTAAAGCTGAGGCCAACTCCC       TGAAGTTAGAGGTCCGAGAACTGGGCCTTGGGGACTCTGGCAGCTACCGCTGTGAGGCCACAAATGTT       CTTGGATCATCCAACACCTCACTCTTCTTCCAGGTCCGAGGTGCCTGGGTCCAGGTGTCACCATCACC       TGAGCTCCAAGAGGGCCAGGCTGTGGTCCTGAGCTGCCAGGTACACACAGGAGTCCCAGAGGGGACCT       CATATCGTTGGTATCGGGATGGCCAGCCCCTCCAGGAGTCGACCTCGGCCACGCTCCGCTTTGCAGCC       ATAACTTTGACACAAGCTGGGGCCTATCATTGCCAAGCCCAGGCCCCAGGCTCAGCCACCACGAGCCT       AGCTGCACCCATCAGCCTCCACGTGTCCTGTAAGGATGCCCCACGCCACGTCACACTCACTACCCTGA       TGGACACAGGCCCTGGACGACTGGGCCTCCTCCTGTGCCGTGTGGACAGTGACCCTCCGGCCCAGCTG       CGGCTGCTCCACGGGGATCGCCTTGTGGCCTCCACCCTACAAGGTGTGGGGGGACCCGAAGGCAGCTC       CCCACGGCTGCATGTGGCTGTGGCCCCCAACACACTGCGTCTGGAGATCCACGGGGCTATGCTGGAGG       ATGAGGGTGTCTATATCTGTGAGGCCTCCAACACCCTGGGCCAGGCCTCGGCCTCAGCTGACTTCGAC       CCTGCCTTGTGTGGACCACTCACCCGGCCCAGCTCACCTACACATGGTACCAGGATGGGCAGCAGCGC       CTGGATGCCCACTCCATCCCCCTGCCCAACGTCACAGTCAGGGATGCCACCTCCTACCGCTGCGGTGT       GGGCCCCCCTGGTCGGGCACCCCGCCTCTCCAGACCTATCACCTTGGACGTCCTCACGCGCCCCGCAA       CCTGCGCCTGACCTACCTCCTGGAGAGCCATGGCGGGCAGCTGGCCCTGGTACTGTGCACTGTGGACA       GCCGCCCGCCCGCCCAGCTGGCCCTCAGCCACGCCGGTCGCCTCTTGGCCTCCTCGACAGCAGCCTCT       GTCCCCAACACCCTGCGCCTGGAGCTGCGAGGGCCACAGCCCAGGGATGAGGGTTTCTACAGCTGCTC       TGCCCGCAGCCCTCTGGGCCAGGCCAACACGTCCCTGGAGCTGCGGCTGGAGGTGCGGGTGATCCTGG       CTCCGGAGGCTGCCGTGCCTGAAGGTGCCCCCATCACAGTGACCTGTGCGGACCCTGCTGCCCACGCA       CCCACACTCTATACTTGGTACCACAACGGTCGTTGGCTGCAGGAGGGTCCAGCTGCCTCACTCTCATT       CCTGGTGGCCACGCGGGCTCATGCAGGCGCCTACTCTTGCCAGGCCCAGGATGCCCAGGGCACCCGCA       GCTCCCGTCCTGCTGCCCTGCAAGTCCTCTGTGCCCCTCAGGA   T   GCTGTCCTGTCCTCCTTCCGGGAC       TCCAGGGCCAGATCCATGGCTGTGATACAGTGCACTGTGGACAGTGAGCCACCTGCTGAGCTGGCCCT       ATCTCATGATGGCAAGGTGCTGGCCACGAGCAGCGGGGTCCACAGCTTGGCATCAGGGACAGGCCATG       TCCAGGTGGCCCGAAACGCCCTACGGCTGCAGGTGCAAGATGTGCCTGCAGGTGATGACACCTATGTT       TGCACAGCCCAAAACTTGCTGGGCTCAATCAGCACCATCGGGCGGTTGCAGGTAGAAGGTGAGTGGCG       GTGGCCCTGGGCCTGTGGGCAACTCCACCTTTGCATGGTTCTGGAATGACCGGCGGCTGCACGCGGAG       CCTGTGCCCACTCTCGCCTTCACCCACGTGGCTCGTGCTCAAGCTGGGATGTACCACTGCCTGGCTGA       GCTCCCCACTGGGGCTGCTGCCTCTGCTCCAGTCATGCTCCGTGTGCTCTACCCTCCCAAGACGCCCA       CCATGATGGTCTTCGTGGAGCCTGAGGGTGGCCTCCGGGGCATCCTGGATTGCCGAGTGGACAGCGAG       CCGCTCGCCAGCCTGACTCTCCACCTTGGCAGTCGACTGGTGGCCTCCAGTCAGCCCCAGGGTGCTCC       TGCAGAGCCACACATCCATGTCCTGGCTTCCCCCAATGCCCTGAGGGTGGACATCGAGGCGCTGAGGC       TTTGGGGTCAGAGCCCTGCACCGCCTGCATCAGTTCCAGCAGCTGCTCTGGGTCCTGGGACTGCTGGT       GGGCCTCCTGCTCCTGCTGTTGGGCCTGGGGGCCTGCTACACCTGGAGAAGGAGGCGTGTTTGTAAGC       AGAGCATGGGCGAGAATCCAGGGCGGGCATCGTCTTTCCATTTACTGCCTCTAGCTGGGTCTTCAAGG         TGA                                           NOV14h,                       SNP13382490 of       CG51821-01,   SEQ ID NO: 412       MW at 180833.0kD       Protein Sequence   SNP Pos: 1352   1700 aa   SNP Change: Asp to Asp                     MGFLPKLLLLASAVLPPGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQR           QVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTV       TGDPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLH       MAMSWQDHGRILRCQLSVANHRAQSEIHLQVKCAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAV       SSIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFVAEVQVSPAGPILEN       QTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVV       VTDPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLR       LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANVARLLISPAAEVVEGQAVTLSCRSGLSPTPDARF       SWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLCEQPPRQPTFTTRLDL       DAAGAGAGPRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIH       NPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWF       RNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMA       LFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNV       LGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAA       ITLTQAGAYHCQAQAPGSATTSLAAPISLHVSCKDAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL       RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFD       GPPWSGTPPLQTYHLGRPHAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAAS       VPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEVRVILAPEAAVPEGAPITVTCADPAAHA       PTLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLCAPQ   D   AVLSSFRD       SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYV       CTAQNLLGSISTIGRLQVEGEWRVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAE       PVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSE       PLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGPASTSTY       FGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENPGPASSFHLLPLAGSSR                                     NOV14i,                   SNP1 3382489 of   SEQ ID NO: 413   5103 bp       CG51821-01,   ORF Start: ATG at 1   ORF Stop: TGA at 5101       DNA Sequence   SNP Pos: 4245   SNP Change: G to A                     ATGGGCTTCTTGCCCAAGCTTCTCCTCCTGGCCTCAGCCGTTCTTCCCCCAGGCCAGGCCTCATGGGG           CGTCTCCAGTCCCCAGGACGTGCAGGGTGTGAAGGGGTCTTGCCTGCTTATCCCCTGCATCTTCAGCT       TCCCTGCCGACGTGGAGGTGCCCGACGGCATCACGGCCATCTGGTACTACGACTACTCGGGCCAGCGG       CAGGTGGTGAGCCACTCGGCGGACCCCAAGCTGGTGGAGGCCCGCTTCCGCGGCCGCACCGAGTTCAT       GGGGAACCCCGAGCACAGGGTGTGCAACCTGCTGCTGAAGGACCTGCAGCCCGAGGACTCTGGTTCCT       ACAACTTCCGCTTCGAGATCAGTGAGGTCAACCGCTGGTCAGATGTGAAAGGCACCTTGGTCACAGTA       ACAGGTGATCCCAGGGTGCCCACCATTGCCTCCCCGGTGGAGCTTCTCGAGGGCACAGAGGTGGACTT       CAACTGCTCCACTCCCTACGTATGCCTGCAGGAGCAGGTCAGACTGCAGTGGCAAGGCCAGGACCCTG       CTCGCTCTGTCACCTTCAACAGCCAGAAGTTTGAGCCCACCGGCGTCGGCCACCTGGAGACCCTCCAC       ATGGCCATGTCCTGGCAGGACCACGGCCGGATCCTGCGCTGCCAGCTCTCCGTGGCCAATCACAGGGC       TCAGAGCGAGATTCACCTCCAAGTGAAGTGTGCCCCCAAGGGTGTGAAGATCCTCCTCAGCCCCTCGG       GGAGGAACATCCTTCCAGGTGAGCTGGTCACACTCACCTGCCAGGTGAACAGCAGCTACCCTGCAGTC       AGTTCCATTAAGTGGCTCAAGGATGGGGTACGCCTCCAAACCAAGACTGGTGTGCTGCACCTGCCCCA       GGCAGCCTGGAGCGATGCTGGCGTCTACACCTGCCAAGCTGAGAACGGCGTGGGCTCTTTGGTCTCAC       CCCCCATCAGCCTCCACATCTTCGTGGCTGAGGTCCAGGTGAGCCCAGCAGGTCCCATCCTGGAGAAC       CAGACAGTGACACTAGTCTGCAACACACCCAATGAGGCACCCAGTGATCTCCGCTACAGCTGGTACAA       GAACCATGTCCTGCTGGAGGATGCCCACTCCCATACCCTCCGGCTGCACTTGGCCACTAGGGCTGATA       CTGGCTTCTACTTCTGTGAGGTGCAGAACGTCCATGGCAGCGAGCGCTCGGGCCCTGTCAGCGTGGTA       GTCACAGACCCGCCTCTCACTCCAGTCCTGACAGCCTTCCTGGAGACCCAGGCGGGACTTGTGGGCAT       CCTTCACTGCTCTGTGGTCAGTGAGCCCCTGGCCACACTGGTGCTGTCACATGGGGGTCATATCCTGG       CCTCCACCTCCGGGGACAGTGATCACAGCCCACGCTTCAGTGGTACCTCTGGTCCCAACTCCCTGCGC       CTGGAGATCCGAGACCTGGAGGAAACTGACAGTGGGGAGTACAAGTGCTCAGCCACCAACTCCCTTGG       AAATGCAACCTCCACCCTGGACTTCCATGCCAATGTCGCCCGTCTCCTCATCAGCCCGGCAGCCGAGG       TGGTGGAAGGACAGGCAGTGACACTGAGCTGCAGAAGCGGCCTAAGCCCCACACCTGATGCCCGCTTC       TCCTGGTACCTGAATGGAGCCCTGCTTCACGAGGGTCCCGGCAGCAGCCTCCTGCTCCCCGCGGCCTC       CAGCACTGACGCCGGCTCATACCACTGCCGGGCCCGGGACGGCCACAGTGCCAGTGGCCCCTCTTCGC       CAGCTGTTCTCACTGTGCTCTGTGAGCAGCCACCACGACAACCAACATTCACCACCAGGCTGGACCTT       CAGGCTGCAGCTGCTCCACAAGGACCGTGTTGTGGCCACTTCCCTGCCATCAGGGGGTGGCTGCAGCA       CCTGTGGGGGCTGTTCCCCACGCATGAAGGTCACCAAAGCCCCCAACTTGCTGCGTGTGGAGATTCAC       AACCCTTTGCTGGAAGAGGAGGGCTTGTACCTCTGTGAGGCCAGCAATGCCCTGGGCAACGCCTCCAC       CTCAGCCACCTTCAATGGCCAGGCCACTGTCCTGGCCATTGCACCATCACACACACTTCAGGAGGGCA       CAGAAGCCAACTTGACTTGCAACGTGAGCCGGGAAGCTGCTGGCAGCCCTGCTAACTTCTCCTGGTTC       CGAAATGGGGTGCTGTGGGCCCAGGGTCCCCTGGAGACCGTGACACTGCTGCCCGTGGCCAGAACTGA       TGCTGCCCTTTACGCCTGCCGCATCCTGACTGAGGCTGGTGCCCAGCTCTCCACTCCCGTGCTCCTGA       GTGTACTCTATCCCCCGGACCGTCCAAAGCTGTCAGCCCTCCTAGACATGGGCCAGGGCCACATGGCT       CTGTTCATCTGCACTGTGGACAGCCGCCCCCTGGCCTTGCTGGCCTTGTTCCATGGGGAGCACCTCCT       GGCCACCAGCCTGGGTCCCCAGGTCCCATCCCATGGTCGGTTCCAGGCTAAAGCTGAGGCCAACTCCC       TGAAGTTAGAGGTCCGAGAACTGGGCCTTGGGGACTCTGGCAGCTACCGCTGTGAGGCCACAAATGTT       CTTGGATCATCCAACACCTCACTCTTCTTCCAGGTCCGAGGTGCCTGGGTCCAGGTGTCACCATCACC       TGAGCTCCAAGAGGGCCAGGCTGTGGTCCTGAGCTGCCAGGTACACACAGGAGTCCCAGAGGGGACCT       CATATCGTTGGTATCGGGATGGCCAGCCCCTCCAGGAGTCGACCTCGGCCACGCTCCGCTTTGCAGCC       ATACTaTTGACACAAGCTGGGGCCTATCATTGCCAAGCCCAGGCCCCAGGCTCAGCCACCACGAGCCT       AGCTGCACCCATCAGCCTCCACGTGTCCTGTAAGGATGCCCCACGCCACGTCACACTCACTACCCTGA       TGGACACAGGCCCTGGACGACTGGGCCTCCTCCTGTGCCGTGTGGACAGTGACCCTCCGGCCCAGCTG       CGGCTGCTCCACGGGGATCGCCTTGTGGCCTCCACCCTACAAGGTGTGGGGGGACCCGAAGGCAGCTC       TCCCAGGCTGCATGTGGCTGTGGCCCCCAACACACTGCGTCTGGAGATCCACGGGGCTATGCTGGAGG       ATGAGGGTGTCTATATCTGTGAGGCCTCCAACACCCTGGGCCAGGCCTCGGCCTCAGCTGACTTCGAC       GCTCAAAGCTGTGAATGTGCAGGTGTGGCCCGGGGCTACCGTGCGGGAGGGGCAGCTGGTGAACCTGA       CCTGGATGCCCACTCCATCCCCCTGCCAACGTCACAGTCAGGGATGCCACCTCCTACCGCTGCGGTGT       GGGCCCCCCTGGTCGGGCACCCCGCCTCTCCAGACCTATCACCTTGGACGTCCTCACGCGCCCCGCAA       CCTGCGCCTGACCTACCTCCTGGAGAGCCATGGCGGGCAGCTGGCCCTGGTACTGTGCACTGTGGACA       GCCGCCCGCCCGCCCAGCTGGCCCTCAGCCACGCCGGTCGCCTCTTGGCCTCCTCGACAGCAGCCTCT       GTCCCCAACACCCTGCGCCTGGAGCTGCGAGGGCCACAGCCCAGGGATGAGGGTTTCTACAGCTGCTC       TGCCCGCAGCCCTCTGGGCCAGGCCAACACGTCCCTGGAGCTGCGGCTGGAGGTGCGGGTGATCCTGG       CTCCGGAGGCTGCCGTGCCTGAAGGTGCCCCCATCACAGTGACCTGTGCGGACCCTGCTGCCCACGCA       CCCACACTCTATACTTGGTACCACAACGGTCGTTGGCTGCAGGAGGGTCCAGCTGCCTCACTCTCATT       CCTGGTGGCCACGCGGGCTCATGCAGGCGCCTACTCTTGCCAGGCCCAGGATGCCCAGGGCACCCGCA       GCTCCCGTCCTGCTGCCCTGCAAGTCCTCTGTGCCCCTCAGGACGCTGTCCTGTCCTCCTTCCGGGAC       TCCAGGGCCAGATCCATGGCTGTGATACAGTGCACTGTGGACAGTGAGCCACCTGCTGAGCTGGCCCT       ATCTCATGATGGCAAGGTGCTGGCCACGAGCAGCGGGGTCCACAGCTTGGCATCAGGGACAGGCCATG       TCCAGGTGGCCCGAAACGCCCT   A   CGGCTACAGGTGCAAGATGTGCCTGCAGGTGATGACACCTATGTT       TGCACAGCCCAAAACTTGCTGGGCTCAATCAGCACCATCGGGCGGTTGCAGGTAGAAGGTGAGTGGCG       CGTGGTGGCAGAGCCTGGCCTGGACGTGCCTGAGGGCGCTGCCCTGAACCTCAGCTGCCGCCTCCTGG       GTGGCCCTGGGCCTGTGGGCAACTCCACCTTTGCATGGTTCTGGAATGACCGGCGGCTGCACGCGGAG       CCTGTGCCCACTCTCGCCTTCACCCACGTGGCTCGTGCTCAAGCTGGGATGTACCACTGCCTGGCTGA       GCTCCCCACTGGGGCTGCTGCCTCTGCTCCAGTCATGCTCCGTGTGCTCTACCCTCCCAAGACGCCCA       CCATGATGGTCTTCGTGGAGCCTGAGGGTGGCCTCCGGGGCATCCTGGATTGCCGAGTGGACAGCGAG       CCGCTCGCCAGCCTGACTCTCCACCTTGGCAGTCGACTGGTGGCCTCCAGTCAGCCCCAGGGTGCTCC       TGCAGAGCCACACATCCATGTCCTGGCTTCCCCCAATGCCCTGAGGGTGGACATCGAGGCGCTGAGGC       CCAGCGACCAAGGGGAATACATCTGTTCTGCCTCAAATGTCCTGGGCCCTGCCTCTACCTCCACCTAC       TTTGGGGTCAGAGCCCTGCACCGCCTGCATCAGTTCCAGCAGCTGCTCTGGGTCCTGGGACTGCTGGT       GGGCCTCCTGCTCCTGCTGTTGGGCCTGGGGGCCTGCTACACCTGGAGAAGGAGGCGTGTTTGTAAGC       AGAGCATGGGCGAGAATCCAGGGCGGGCATCGTCTTTCCATTTACTGCCTCTAGCTGGGTCTTCAAGG         TGA                                           NOV14i,                       SNP1 3382489 of       CG51821-01,   SEQ ID NO: 414       MW at 180833.0kD       Protein Sequence   SNP Pos: 1415   1700 aa   SNP Change: Leu to Leu                     MGFLPKLLLLASAVLPPGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQR           QVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTV       TGDPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLH       MAMSWQDHGRILRCQLSVANHRAQSEIHLQVKCAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAV       SSIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFVAEVQVSPAGPILEN       QTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATEADTGFYFCEVQNVHGSERSGPVSVV       VTDPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLR       LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANVARLLISPAAEVVEGQAVTLSCRSGLSPTPDARF       SWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPATLTVLCEQPPRQPTFTTRLDL       DAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIH       NPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWF       RNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMA       LFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNV       LGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAA       ITLTQAGAYHCQAQAPGSATTSLAAPISLHVSCKDAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL       RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFD       AQSCECAGVARGYRAGGAAGEPDLPCVDHSPGPAHLHMVPGWAAAPGCPLHPPAQRHSQGCHLLPLRC       GPPWSGTPPLQTYHLGRPHAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAAS       VPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEVRVILAPEAAVPEGAPITVTCADPAAHA       PTLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQTLCAPQDAVLSSFRD       SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALR   L   QVQDVPAGDDTYV       CTAQNLLGSISTIGRLQVEGEWRVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAE       PVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSE       PLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGPASTSTY       FGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENPGRASSFHLLPLAGSSR                                     NOV14j,                   SNP1 3377616 of   SEQ ID NO: 415   5103 bp       CG51821-01,   ORF Start: ATG at 1   ORF Stop: TGA at 5101       DNA Sequence SNP Pos: 4768   SNP Change: C to T                       ATG GGCTTCTTGCCCAAGCTTCTCCTCCTGGCCTCAGCCGTTCTTCCCCCAGGCCAGGCCTCATGGGG           CGTCTCCAGTCCCCAGGACGTGCAGGGTGTGAAGGGGTCTTGCCTGCTTATCCCCTGCATCTTCAGCT       TCCCTGCCGACGTGGAGGTGCCCGACGGCATCACGGCCATCTGGTACTACGACTACTCGGGCCAGCGG       GGGGAACCCCGAGCACAGGGTGTGCAACCTGCTGCTGAAGGACCTGCAGCCCGAGGACTCTGGTTCCT       ACAACTTCCGCTTCGAGATCAGTGAGGTCAACCGCTGGTCAGATGTGAAAGGCACCTTGGTCACAGTA       ACAGGTGATCCCAGGGTGCCCACCATTGCCTCCCCGGTGGAGCTTCTCGAGGGCACAGAGGTGGACTT       CAACTGCTCCACTCCCTACGTATGCCTGCAGGAGCAGGTCAGACTGCAGTGGCAAGGCCAGGACCCTG       CTCGCTCTGTCACCTTCAACAGCCAGAAGTTTGAGCCCACCGGCGTCGGCCACCTGGAGACCCTCCAC       TCAGAGCGAGATTCACCTCCAAGTGAAGTGTGCCCCCAAGGGTGTGAAGATCCTCCTCAGCCCCTCGG       GGAGGAACATCCTTCCAGGTGAGCTGGTCACACTCACCTGCCAGGTGAACAGCAGCTACCCTGCAGTC       AGTTCCATTAAGTGGCTCAAGGATGGGGTACGCCTCCAAACCAAGACTGGTGTGCTGCACCTGCCCCA       GGCAGCCTGGAGCGATGCTGGCGTCTACACCTGCCAAGCTGAGAACGGCGTGGGCTCTTTGGTCTCAC       CCCCCATCAGCCTCCACATCTTCGTGGCTGAGGTCCAGGTGAGCCCAGCAGGTCCCATCCTGGAGAAC       CAGACAGTGACACTAGTCTGCAACACACCCAATGAGGCACCCAGTGATCTCCGCTACAGCTGGTACAA       GAACCATGTCCTGCTGGAGGATGCCCACTCCCATACCCTCCGGCTGCACTTGGCCACTAGGGCTGATA       CTGGCTTCTACTTCTGTGAGGTGCAGAACGTCCATGGCAGCGAGCGCTCGGGCCCTGTCAGCGTGGTA       GTCACAGACCCGCCTCTCACTCCAGTCCTGACAGCCTTCCTGGAGACCCAGGCGGGACTTGTGGGCAT       CCTTCACTGCTCTGTGGTCAGTGAGCCCCTGGCCACACTGGTGCTGTCACATGGGGGTCATATCCTGG       CCTCCACCTCCGGGGACAGTGATCACAGCCCACGCTTCAGTGGTACCTCTGGTCCCAACTCCCTGCGC       CTGGAGATCCGAGACCTGGAGGAAACTGACAGTGGGGAGTACAAGTGCTCAGCCACCAACTCCCTTGG       AAATGCAACCTCCACCCTGGACTTCCATGCCAATGTCGCCCGTCTCCTCATCAGCCCGGCAGCCGAGG       TGGTGGAAGGACAGGCAGTGACACTGAGCTGCAGAAGCGGCCTAAGCCCCACACCTGATGCCCGCTTC       TCCTGGTACCTGAATGGAGCCCTGCTTCACGAGGGTCCCGGCAGCAGCCTCCTGCTCCCCGCGGCCTC       CAGCACTGACGCCGGCTCATACCACTGCCGGGCCCGGGACGGCCACAGTGCCAGTGGCCCCTCTTCGC       CAGCTGTTCTCACTGTGCTCTGTGAGCAGCCACCACGACAACCAACATTCACCACCAGGCTGGACCTT       GATGCCGCTGGGGCCGGGGCTGGACGGCGAGGCCTCCTTTTGTGCCGTGTGGACAGCGACCCCCCCGC       CAGGCTGCAGCTGCTCCACAAGGACCGTGTTGTGGCCACTTCCCTGCCATCAGGGGGTGGCTGCAGCA       CCTGTGGGGGCTGTTCCCCACGCATGAAGGTCACCAAAGCCCCCAACTTGCTGCGTGTGGAGATTCAC       AACCCTTTGCTGGAAGAGGAGGGCTTGTACCTCTGTGAGGCCAGCAATGCCCTGGGCAACGCCTCCAC       CTCAGCCACCTTCAATGGCCAGGCCACTGTCCTGGCCATTGCACCATCACACACACTTCAGGAGGGCA       CAGAAGCCAACTTGACTTGCAACGTGAGCCGGGAAGCTGCTGGCAGCCCTGCTAACTTCTCCTGGTTC       CGAAATGGGGTGCTGTGGGCCCAGGGTCCCCTGGAGACCGTGACACTGCTGCCCGTGGCCAGAACTGA       TGCTGCCCTTTACGCCTGCCGCATCCTGACTGAGGCTGGTGCCCAGCTCTCCACTCCCGTGCTCCTGA       CTGTTCATCTGCACTGTGGACAGCCGCCCCCTGGCCTTGCTGGCCTTGTTCCATGGGGAGCACCTCCT       GGCCACCAGCCTGGGTCCCCAGGTCCCATCCCATGGTCGGTTCCAGGCTAAAGCTGAGGCCAACTCCC       TGAAGTTAGAGGTCCGAGAACTGGGCCTTGGGGACTCTGGCAGCTACCGCTGTGAGGCCACAAATGTT       CTTGGATCATCCAACACCTCACTCTTCTTCCAGGTCCGAGGTGCCTGGGTCCAGGTGTCACCATCACC       TGAGCTCCAAGAGGGCCAGGCTGTGGTCCTGAGCTGCCAGGTACACACAGGAGTCCCAGAGGGGACCT       CATATCGTTGGTATCGGGATGGCCAGCCCCTCCAGGAGTCGACCTCGGCCACGCTCCGCTTTGCAGCC       AGCTGCACCCATCAGCCTCCACGTGTCCTGTAAGGATGCCCCACGCCACGTCACACTCACTACCCTGA       TGGACACAGGCCCTGGACGACTGGGCCTCCTCCTGTGCCGTGTGGACAGTGACCCTCCGGCCCAGCTG       TCCCAGGCTGCATGTGGCTGTGGCCCCCAACACACTGCGTCTGGAGATCCACGGGGCTATGCTGGAGG       GCTCAAAGCTGTGAATGTGCAGGTGTGGCCCGGGGCTACCGTGCGGGAGGGGCAGCTGGTGAACCTGA       CCTGCCTTGTGTGGACCACTCACCCGGCCCAGCTCACCTACACATGGTACCAGGATGGGCAGCAGCGC       CTGGATGCCCACTCCATCCCCCTGCCCAACGTCACAGTCAGGGATGCCACCTCCTACCGCTGCGGTGT       GGGCCCCCCTGGTCGGGCACCCCGCCTCTCCAGACCTATCACCTTGGACGTCCTCACGCGCCCCGCAA       CCTGCGCCTGACCTACCTCCTGGAGAGCCATGGCGGGCAGCTGGCCCTGGTACTGTGCACTGTGGACA       GCCGCCCGCCCGCCCAGCTGGCCCTCAGCCACGCCGGTCGCCTCTTGGCCTCCTCGACAGCAGCCTCT       GTCCCCAACACCCTGCGCCTGGAGCTGCGAGGGCCACAGCCCAGGGATGAGGGTTTCTACAGCTGCTC       TGCCCGCAGCCCTCTGGGCCAGGCCAACACGTCCCTGGAGCTGCGGCTGGAGGTGCGGGTGATCCTGG       CTCCGGAGGCTGCCGTGCCTGAAGGTGCCCCCATCACAGTGACCTGTGCGGACCCTGCTGCCCACGCA       CCCACACTCTATACTTGGTACCACAACGGTCGTTGGCTGCAGGAGGGTCCAGCTGCCTCACTCTCATT       CCTGGTGGCCACGCGGGCTCATGCAGGCGCCTACTCTTGCCAGGCCCAGGATGCCCAGGGCACCCGCA       GCTCCCGTCCTGCTGCCCTGCAAGTCCTCTGTGCCCCTCAGGACGCTGTCCTGTCCTCCTTCCGGGAC       TCCAGGGCCAGATCCATGGCTGTGATACAGTGCACTGTGGACAGTGAGCCACCTGCTGAGCTGGCCCT       ATCTCATGATGGCAAGGTGCTGGCCACGAGCAGCGGGGTCCACAGCTTGGCATCAGGGACAGGCCATG       TGCACAGCCCAAAACTTGCTGGGCTCAATCAGCACCATCGGGCGGTTGCAGGTAGAAGGTGAGTGGCG       CGTGGTGGCAGAGCCTGGCCTGGACGTGCCTGAGGGCGCTGCCCTGAACCTCAGCTGCCGCCTCCTGG       GTGGCCCTGGGCCTGTGGGCAACTCCACCTTTGCATGGTTCTGGAATGACCGGCGGCTGCACGCGGAG       CCTGTGCCCACTCTCGCCTTCACCCACGTGGCTCGTGCTCAAGCTGGGATGTACCACTGCCTGGCTGA       GCTCCCCACTGGGGCTGCTGCCTCTGCTCCAGTCATGCTCCGTGTGCTCTACCCTCCCAAGACGCCCA       CCGCTCGCCAGCCTGACTCTCCACCTTGGCAGTCGACTGGTGGCCTCCAGTCAGCCCCAGGGTGCTCC       TGCAGAG   T   CACACATCCATGTCCTGGCTTCCCCCAATGCCCTGAGGGTGGACATCGAGGCGCTGAGGC       CCAGCGACCAAGGGGAATACATCTGTTCTGCCTCAAATGTCCTGGGCCCTGCCTCTACCTCCACCTAC       TTTGGGGTCAGAGCCCTGCACCGCCTGCATCAGTTCCAGCAGCTGCTCTGGGTCCTGGGACTGCTGGT       GGGCCTCCTGCTCCTGCTGTTGGGCCTGGGGGCCTGCTACACCTGGAGAAGGAGGCGTGTTTGTAAGC       AGAGCATGGGCGAGAATCCAGGGCGGGCATCGTCTTTCCATTTACTGCCTCTAGCTGGGTCTTCAAGG         TGA                                           NOV14j,                       SNP13377616 of       CG51821-01,   SEQ ID NO: 416       MW at 180822.9kD       Protein Sequence   SNP Pos: 1590   1700 aa   SNP Change: Pro to Ser                     MGFLPKLLLLASAVLPPGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQR           QVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTV       TGDPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLH       MAMSWQDHGRILRCQLSVANHRAQSEIHLQVKCAPKGVKILLSPSGPNILPGELVTLTCQVNSSYPAV       SSIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFVAEVQVSPAGPILEN       QTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVV       VTDPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLR       LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANVARLLISPAAEVVEGQAVTLSCRSGLSPTPDARF       SWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLCEQPPRQPTFTTRLDL       DAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIH       NPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWF       RNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMA       LFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNV       LGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAA       TLTQAGAYHCQAQAPGSATTSLAAPISLHVSCKDAPRHVTLTTLLMDTGPGRLGLLLCRVDSDPPAQL       RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFD       AQSCECAGVARGYRAGGAAGEPDLPCVDHSPGPAHLHMVPGWAAAPGCPLHPPAQRHSQGCHLLPLRC       GPPWSGTPPLQTYHLGRPHAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAAS       VPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEVRVILAPEAAVPEGAPITVTCADPAAHA       PTLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLCAPQDAVLSSFRD       SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYV       CTAQNLLGSISTIGRIJQVEGEWRWAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAE       PVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSE       PLASLTLHLGSPLVASSQPQGAPAE   S   HIHVLASPNALRVDIEALRPSDQGEYICSASNVLGPASTSTY       FGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENPGRASSFHLLPLAGSSR                                         NOV14k,                    SNP13377617 of   SEQ ID NO: 417   5103 bp           CG51821-01,   ORF Start: ATG at 1   ORF Stop: TGA at 5101           DNA Sequence   SNP Pos: 4881   SNP Change: C to T                       ATG GGCTTCTTGCCCAAGCTTCTCCTCCTGGCCTCAGCCGTTCTTCCCCCAGGCCAGGCCTCATGGGG           CGTCTCCAGTCCCCAGGACGTGCAGGGTGTGAAGGGGTCTTGCCTGCTTATCCCCTGCATCTTCAGCT       CAGGTGGTGAGCCACTCGGCGGACCCCAAGCTGGTGGAGGCCCGCTTCCGCGGCCGCACCGAGTTCAT       GGGGAACCCCGAGCACAGGGTGTGCAACCTGCTGCTGAAGGACCTGCAGCCCGAGGACTCTGGTTCCT       ACAACTTCCGCTTCGAGATCAGTGAGGTCAACCGCTGGTCAGATGTGAAAGGCACCTTGGTCACAGTA       ACAGGTGATCCCAGGGTGCCCACCATTGCCTCCCCGGTGGAGCTTCTCGAGGGCACAGAGGTGGACTT       CAACTGCTCCACTCCCTACGTATGCCTGCAGGAGCAGGTCAGACTGCAGTGGCAAGGCCAGGACCCTG       CTCGCTCTGTCACCTTCAACAGCCAGAAGTTTGAGCCCACCGGCGTCGGCCACCTGGAGACCCTCCAC       ATGGCCATGTCCTGGCAGGACCACGGCCGGATCCTGCGCTGCCAGCTCTCCGTGGCCAATCACAGGGC       TCAGAGCGAGATTCACCTCCAAGTGAAGTGTGCCCCCAAGGGTGTGAAGATCCTCCTCAGCCCCTCGG       GGAGGAACATCCTTCCAGGTGAGCTGGTCACACTCACCTGCCAGGTGAACAGCAGCTACCCTGCAGTC       AGTTCCATTAAGTGGCTCAAGGATGGGGTACGCCTCCAAACCAAGACTGGTGTGCTGCACCTGCCCCA       GGCAGCCTGGAGCGATGCTGGCGTCTACACCTGCCAAGCTGAGAACGGCGTGGGCTCTTTGGTCTCAC       CCCCCATCAGCCTCCACATCTTCGTGGCTGAGGTCCAGGTGAGCCCAGCAGGTCCCATCCTGGAGAAC       CAGACAGTGACACTAGTCTGCAACACACCCAATGAGGCACCCAGTGATCTCCGCTACAGCTGGTACAA       CTGGCTTCTACTTCTGTGAGGTGCAGAACGTCCATGGCAGCGAGCGCTCGGGCCCTGTCAGCGTGGTA       GTCACAGACCCGCCTCTCACTCCAGTCCTGACAGCCTTCCTGGAGACCCAGGCGGGACTTGTGGGCAT       CCTTCACTGCTCTGTGGTCAGTGAGCCCCTGGCCACACTGGTGCTGTCACATGGGGGTCATATCCTGG       CCTCCACCTCCGGGGACAGTGATCACAGCCCACGCTTCAGTGGTACCTCTGGTCCCAACTCCCTGCGC       CTGGAGATCCGAGACCTGGAGGAAACTGACAGTGGGGAGTACAAGTGCTCAGCCACCAACTCCCTTGG       AAATGCAACCTCCACCCTGGACTTCCATGCCAATGTCGCCCGTCTCCTCATCAGCCCGGCAGCCGAGG       TGGTGGAAGGACAGGCAGTGACACTGAGCTGCAGAAGCGGCCTAAGCCCCACACCTGATGCCCGCTTC       TCCTGGTACCTGAATGGAGCCCTGCTTCACGAGGGTCCCGGCAGCAGCCTCCTGCTCCCCGCGGCCTC       CAGCACTGACGCCGGCTCATACCACTGCCGGGCCCGGGACGGCCACAGTGCCAGTGGCCCCTCTTCGC       CAGCTGTTCTCACTGTGCTCTGTGAGCAGCCACCACGACAACCAACATTCACCACCAGGCTGGACCTT       GATGCCGCTGGGGCCGGGGCTGGACGGCGAGGCCTCCTTTTGTGCCGTGTGGACAGCGACCCCCCCGC       CAGGCTGCAGCTGCTCCACAAGGACCGTGTTGTGGCCACTTCCCTGCCATCAGGGGGTGGCTGCAGCA       CCTGTGGGGGCTGTTCCCCACGCATGAAGGTCACCAAAGCCCCCAACTTGCTGCGTGTGGAGATTCAC       AACCCTTTGCTGGAAGAGGAGGGCTTGTACCTCTGTGAGGCCAGCAATGCCCTGGGCAACGCCTCCAC       CTCAGCCACCTTCAATGGCCAGGCCACTGTCCTGGCCATTGCACCATCACACACACTTCAGGAGGGCA       CAGAAGCCAACTTGACTTGCAACGTGAGCCGGGAAGCTGCTGGCAGCCCTGCTAACTTCTCCTGGTTC       CGAAATGGGGTGCTGTGGGCCCAGGGTCCCCTGGAGACCGTGACACTGCTGCCCGTGGCCAGAACTGA       TGCTGCCCTTTACGCCTGCCGCATCCTGACTGAGGCTGGTGCCCAGCTCTCCACTCCCGTGCTCCTGA       GTGTACTCTATCCCCCGGACCGTCCAAAGCTGTCAGCCCTCCTAGACATGGGCCAGGGCCACATGGCT       CTGTTCATCTGCACTGTGGACAGCCGCCCCCTGGCCTTGCTGGCCTTGTTCCATGGGGAGCACCTCCT       GGCCACCAGCCTGGGTCCCCAGGTCCCATCCCATGGTCGGTTCCAGGCTAAAGCTGAGGCCAACTCCC       TGAAGTTAGAGGTCCGAGAACTGGGCCTTGGGGACTCTGGCAGCTACCGCTGTGAGGCCACAAATGTT       CTTGGATCATCCAACACCTCACTCTTCTTCCAGGTCCGAGGTGCCTGGGTCCAGGTGTCACCATCACC       TGAGCTCCAAGAGGGCCAGGCTGTGGTCCTGAGCTGCCAGGTACACACAGGAGTCCCAGAGGGGACCT       CATATCGTTGGTATCGGGATGGCCAGCCCCTCCAGGAGTCGACCTCGGCCACGCTCCGCTTTGCAGCC       ATAACTTTGACACAAGCTGGGGCCTATCATTGCCAAGCCCAGGCCCCAGGCTCAGCCACCACGAGCCT       AGCTGCACCCATCAGCCTCCACGTGTCCTGTAAGGATGCCCCACGCCACGTCACACTCACTACCCTGA       TGGACACAGGCCCTGGACGACTGGGCCTCCTCCTGTGCCGTGTGGACAGTGACCCTCCGGCCCAGCTG       CGGCTGCTCCACGGGGATCGCCTTGTGGCCTCCACCCTACAAGGTGTGGGGGGACCCGAAGGCAGCTC       TCCCAGGCTGCATGTGGCTGTGGCCCCCAACACACTGCGTCTGGAGATCCACGGGGCTATGCTGGAGG       ATGAGGGTGTCTATATCTGTGAGGCCTCCAACACCCTGGGCCAGGCCTCGGCCTCAGCTGACTTCGAC       GCTCAAAGCTGTGAATGTGCAGGTGTGGCCCGGGGCTACCGTGCGGGAGGGGCAGCTGGTGAACCTGA       CCTGCCTTGTGTGGACCACTCACCCGGCCCAGCTCACCTACACATGGTACCAGGATGGGCAGCAGCGC       GGGCCCCCCTGGTCGGGCACCCCGCCTCTCCAGACCTATCACCTTGGACGTCCTCACGCGCCCCGCAA       CCTGCGCCTGACCTACCTCCTGGAGAGCCATGGCGGGCAGCTGGCCCTGGTACTGTGCACTGTGGACA       CCGCCCGCACCGCCCAGCTGGCCCTCAGCCACGCCGGTCGCCTCTTGGCCTCCTCGACAGCAGCCTCT       GTCCCCAACACCCTGCGCCTGGAGCTGCGAGGGCCACAGCCCAGGGATGAGGGTTTCTACAGCTGCTC       TGCCCGCAGCCCTCTGGGCCAGGCCAACACGTCCCTGGAGCTGCGGCTGGAGGTGCGGGTGATCCTGG       CCCACACTCTATACTTGGTACCACAACGGTCGTTGGCTGCAGGAGGGTCCAGCTGCCTCACTCTCATT       CCTGGTGGCCACGCGGGCTCATGCAGGCGCCTACTCTTGCCAGGCCCAGGATGCCCAGGGCACCCGCA       GCTCCCGTCCTGCTGCCCTGCAAGTCCTCTGTGCCCCTCAGGACGCTGTCCTGTCCTCCTTCCGGGAC       TCCAGGGCCAGATCCATGGCTGTGATACAGTGCACTGTGGACAGTGAGCCACCTGCTGAGCTGGCCCT       ATCTCATGATGGCAAGGTGCTGGCCACGAGCAGCGGGGTCCACAGCTTGGCATCAGGGACAGGCCATG       TCCAGGTGGCCCGAAACGCCCTACGGCTGCAGGTGCAAGATGTGCCTGCAGGTGATGACACCTATGTT       TGCACAGCCCAAAACTTGCTGGGCTCAATCAGCACCATCGGGCGGTTGCAGGTAGAAGGTGAGTGGCG       CGTGGTGGCAGAGCCTGGCCTGGACGTGCCTGAGGGCGCTGCCCTGAACCTCAGCTGCCGCCTCCTGG       GTGGCCCTGGGCCTGTGGGCAACTCCACCTTTGCATGGTTCTGGAATGACCGGCGGCTGCACGCGGAG       CCTGTGCCCACTCTCGCCTTCACCCACGTGGCTCGTGCTCAAGCTGGGATGTACCACTGCCTGGCTGA       GCTCCCCACTGGGGCTGCTGCCTCTGCTCCAGTCATGCTCCGTGTGCTCTACCCTCCCAAGACGCCCA       CCGCTCGCCAGCCTGACTCTCCACCTTGGCAGTCGACTGGTGGCCTCCAGTCAGCCCCAGGGTGCTCC       TGCAGAGCCACACATCCATGTCCTGGCTTCCCCCAATGCCCTGAGGGTGGACATCGAGGCGCTGAGGC       CCAGCGACCAAGGGGAATACATCTGTTCTGCCTCAAATGTCCTGGGCCCTGC   T   TCTACCTCCACCTAC       TTTGGGGTCAGAGCCCTGCACCGCCTGCATCAGTTCCAGCAGCTGCTCTGGGTCCTGGGACTGCTGGT       GGGCCTCCTGCTCCTGCTGTTGGGCCTGGGGGCCTGCTACACCTGGAGAAGGAGGCGTGTTTGTAAGC       AGAGCATGGGCGAGAATCCAGGGCGGGCATCGTCTTTCCATTTACTGCCTCTAGCTGGGTCTTCAAGG         TGA                                           NOV14k,                       SNP1 3377617 of       CG51821-01,   SEQ ID NO: 4181       MW at 180833.0kD       Protein Sequence   SNP Pos: 1627   1700 aa   SNP Change: Ala to Ala                     MGFLPKLLLLASAVLPPGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQR           QVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTV       TGDPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQDPARSVTFNSQKFEPTGVGHLETLH       MAMSWQDHGRILRCQLSVANHRAQSEIHLQVKCAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAV       SSIKWLKDGVRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFVAEVQVSPAGPILEN       QTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVV       VTDPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLR       LEIRDLEETDSGEYKCSATNSLGNATSTLDFHANVARLLISPAAEVVEGQAVTLSCRSGLSPTPDARF       SWYLNGALLHEGPGSSLLLPAASSTDAGSYHCPARDGHSASGPSSPAVLTVLCEQPPRQPTFTTRLDL       DAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIH       NPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWF       RNGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMA       LFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNV       LGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAA       ITLTQAGAYHCQAQAPGSATTSLAAPISLHVSCKDAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL       RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGANLEDEGVYICEASNTLGQASASADFD       AQSCECAGVARGYRAGGAAGEPDLPCVDHSPGPAHLHMVPGWAAAPGCPLHPPAQRHSQGCHLLPLRC       GPPWSGTPPLQTYHLGRPHAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAAS       VPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEVRVILAPEAAVPEGAPITVTCADPAAHA       PTLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLCAPQDAVLSSFRD       SRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVAPNALRLQVQDVPAGDDTYV       CTAQNLLGSISTIGRLQVEGEWRVVAEPGLDVPEAGAALNLSCRLLGPGPVGNSTFAWFWNDRRLHAE       PVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSE       PLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGPASTSTY       FGVRALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCKQSMGENPGRASSFHLLPTAGSSR                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 14B.  
                   TABLE 14B                       Comparison of the NOV14 protein sequences.                                            NOV14a   MGFLPKLLLLASAVLPPGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIW           NOV14b   ------------------RSSWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIW       NOV14c   ------------------RSSWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIW       NOV14d   ------------------RSSWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIW       NOV14e   --------------------SWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIW       NOV14f   --------------------SWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIW       NOV14g   MGFLPKLLLLAS-FFPAGQASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIW               NOV14a   YYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEI       NOV14b   YYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEI       NOV14c   YYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEI       NOV14d   YYDYSGQRQVVSHSVDPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEI       NOV14e   YYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEI       NOV14f   YYDYSGQRQVVSHSVDPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEI       NOV14g   YYDYSGQRQVVSHSADPKLVEARFRGRTEFMGNPEHRVCNLLLKDLQPEDSGSYNFRFEI               NOV14a   SEVNRWSDVKGTLVTVTGDPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQD       NOV14b   SEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQD       NOV14c   SEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQD       NOV14d   SEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQD       NOV14e   SEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQD       NOV14f   SEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQD       NOV14g   SEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQWQGQD               NOV14a   PARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKCAPK       NOV14b   PARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPR       NOV14c   PARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSMANHRAQSEIHLQVKYAPR       NOV14d   PARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSMANHRAQSEIHLQVKYAPK       NOV14e   PARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPR       NOV14f   PARSVTFNSQKFEPTGVGHLETLHNAMSWQDHGRILRCQLSMANHRAQSEIHLQVKYAPK       NOV14g   PARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPK               NOV14a   GVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSD       NOV14b   GVKILLSPSGRNILPVD-------------------------------------------       NOV14c   GVKILLSPSGRNILPVD-------------------------------------------       NOV14d   GVKILLSPSGRNILPVD-------------------------------------------       NOV14e   GVKILLSPSGRNILP---------------------------------------------       NOV14f   GVKILLSPSGRNILP---------------------------------------------       NOV14g   GVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQAAWSD               NOV14a   AGVYTCQAENGVGSLVSPPISLHIFVAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYS       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   AGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYS               NOV14a   WYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVTDPPLTPVLTA       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   WYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTA               NOV14a   FLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIR       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   FLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIR               NOV14a   DLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTP       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   DLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVEGQAVTLSCRSGLSPTP               NOV14a   DARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLCEQP       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   DARFSWYLNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLY--P               NOV14a   PRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCG       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   PRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCG               NOV14a   GCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSH       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   GCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQATVLAIAPSH               NOV14a   TLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRIL       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   TLQEGTEANLTCNVSREAAGSPANFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRIL               NOV14a   TEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLA       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   TEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGHMALFICTVDSRPLALLALFHGEHLLA               NOV14a   TSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAW       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   TSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAW               NOV14a   VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGA       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   VQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGA               NOV14a   YHCQAQAPGSATTSLAAPISLBVSCKDAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   YHCQAQAPGSATTSLAAPISLHVSY--APRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQL               NOV14a   RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQ       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   RLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLETHGAMLEDEGVYICEASNTLGQ               NOV14a   ASASADFDAQSCECAGVARGYRAGGAAGEPDLPCVDHSPGPAHLHMVPGWAAAPGCPLHP       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   ASASADFDAQAVNVQVWPGATVREGQLVN--LTCLVWTTHPAQLTYTWYQDGQQRLDAHS               NOV14a   PAQRHSQGCHLLPLRCG--PPWSGTPPLQTYHLGRPHAPRNLRLTYLLESHGGQLALVLC       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   IPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLC               NOV14a   TVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTS       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   TVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTS               NOV14a   LELRLE-VRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLV       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   LELRLEGVRVILAPEAAVPEGAPITVTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLV               NOV14a   ATRAHAGAYSCQAQDAQGTRSSRPAALQVLCAPQDAVLSSFRDSRARSMAVIQCTVDSEP       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   ATPAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEP               NOV14a   PAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGS       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   PAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGS               NOV14a   ISTIGRLQVEGEWRVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   ISTIGRLQVEGAR-VVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEP               NOV14a   VPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGIL       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   VPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTNMVFVEPEGGLRGIL               NOV14a   DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   DCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYI               NOV14a   CSASNVLGPASTSTYFGVPALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCK       NOV14b   ------------------------------------------------------------       NOV14c   ------------------------------------------------------------       NOV14d   ------------------------------------------------------------       NOV14e   ------------------------------------------------------------       NOV14f   ------------------------------------------------------------       NOV14g   CSASNVLGSASTSTYFGVPALHRLHQFQQLLWVLGLLVGLLLLLLGLGACYTWRRRRVCK               NOV14a   QSMGENP-----GEASSFHLLPLAGSSR---------       NOV14b   -------------------------------------       NOV14c   -------------------------------------       NOV14d   -------------------------------------       NOV14e   -------------------------------------       NOV14f   -------------------------------------       NOV14g   QSMGENSVEMAFQKETTQLIDPDAATCETSTCAPPLG               NOV14a   (SEQ ID NO: 398)       NOV14b   (SEQ ID NO: 400)       NOV14c   (SEQ ID NO: 402)       NOV14d   (SEQ ID NO: 404)       NOV14e   (SEQ ID NO: 406)       NOV14f   (SEQ ID NO: 408)       NOV14g   (SEQ ID NO: 410)                  
 
      Further analysis of the NOV14a protein yielded the following properties shown in Table 14C.  
               TABLE 14C                       Protein Sequence Properties NOV14a                                         SignalP analysis:   Cleavage site between residues 21 and 22       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 6; pos. chg 1; neg. chg 0           H-region:   length 22; peak value 9.20           PSG score:   4.80                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 2.74           possible cleavage site: between 20 and 21                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 20)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 21           Tentative number of TMS(s) for the threshold 0.5: 3           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane               −11.25   1647-1663                             PERIPHERAL   Likelihood =0.69 (at 36)                         ALOM score: −11.25 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 10           Charge difference: −2.0 C(0.0)-N(2.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 1a (cytoplasmic tail 1664 to 1700)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   6.81           Hyd Moment(95):   7.54   G content:   3           D/E content:   1   S/T content:   4                         Score: −4.95       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: RRRR (5) at 1671           pat7: none           bipartite: none           content of basic residues: 7.3%           NLS Score: −0.16       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: 1667       Dileucine motif in the tail: found                         LL at 1692                 checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 55.5       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         33.3%: endoplasmic reticulum           22.2%: Golgi           22.2%: extracellular, including cell wall           11.1%: plasma membrane           11.1%: vesicles of secretory system                 &gt;&gt; prediction for CG51821-01 is end (k = 9)                  
 
      A search of the NOV14a protein against the Geneseq database, a proprietary database that contains sequences published in. patents and patent publication, yielded several homologous proteins shown in Table 14D.  
               TABLE 14D                          Geneseq Results for NOV14a                                          NOV14a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               ABB05044   Human NOV6 protein SEQ ID NO: 24 -   1 . . . 1700   1700/1700 (100%)    0.0             Homo sapiens , 1700 aa.   1 . . . 1700   1700/1700 (100%)            [WO200190155-A2, 29-NOV-2001]       AAE09448   Human sbg24878Sla protein #1 -   1 . . . 1683   1588/1695 (93%)   0.0             Homo sapiens , 1709 aa.   1 . . . 1672   1598/1695 (93%)           [WO200160850-A1, 23-AUG-2001]       ME09449   Human sbg24878Sla protein #2 -   1 . . . 1671   1576/1683 (93%)   0.0             Homo sapiens , 1694 aa.   1 . . . 1660   1586/1683 (93%)           [WO200160850-A1, 23-AUG-2001]       ABG10466   Novel human diagnostic protein   18 . . . 1671    1562/1666 (93%)   0.0           #10457 -  Homo sapiens , 1839 aa.   162 . . . 1805    1573/1666 (93%)           [WO200175067-A2, 11-OCT-2001]       ABP69461   Human polypeptide SEQ ID NO   482 . . . 1683    1118/1214 (92%)   0.0           1508 -  Homo sapiens , 1263 aa.   35 . . . 1232    1126/1214 (92%)           [WO200270539-A2, 12-SEP-2002]                  
 
      In a BLAST search of public sequence databases, the NOV14a protein was found to have homology to the proteins shown in the BLASTP data in Table 14E.  
               TABLE 14E                          Public BLASTP Results for NOV14a                                         NOV14a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             Q9BZZ2   Sialoadhesin precursor (Sialic acid    1 . . . 1683   1594/1695   (94%)   0.0           binding Ig-like lectin-1) (Siglec- 1)    1 . . . 1678   1603/1695   (94%)           (CD169 antigen) -  Homo sapiens             (Human), 1709 aa.       Q62230   Sialoadhesin precursor (Sialic acid    8 . . . 1683   1167/1688   (69%)   0.0           binding Ig-like lectin-1) (Siglec- 1)    7 . . . 1675   1333/1688   (78%)           (Sheep erythrocyte receptor) (SER) -             Mus musculus  (Mouse), 1694 aa.       BAC56927   FLJ00411 protein -  Homo sapiens     798 . . . 1091    288/294   (97%)    e−162           (Human), 437 aa (fragment).   17 . . . 308    289/294   (97%)       P35329   B-cell receptor CD22 precursor (Leu-   22 . . . 634    167/649   (25%)   5e−37           14) (B-lymphocyte cell adhesion   26 . . . 638    274/649   (41%)           molecule) (BL-CAM) (Siglec-2) -  Mus               musculus  (Mouse), 862 aa.       A46512   CD22 homolog/B lymphocyte-   22 . . . 634    163/653   (24%)   6e−35           restricted adhesion molecule - mouse,   26 . . . 644    271/653   (40%)           868 aa.                  
 
      PFam analysis predicts that the NOV14a protein contains the domains shown in the Table 14F.  
               TABLE 14F                          Domain Analysis of NOV14a                                             Identities/                       Similarities           Pfam   NOV14a   for the   Expect           Domain   Match Region   Matched Region   Value                       ig   256 . . . 308   20/54 (37%)   1.5e−11                   43/54 (80%)           ig   340 . . . 393   17/55 (31%)   4.3e−10                   44/55 (80%)           ig   427 . . . 494   17/71 (24%)   0.0082                   51/71 (72%)           ig   525 . . . 578   16/55 (29%)   2.1e−06                   39/55 (71%)           ig   620 . . . 694   12/78 (15%)   0.92                   53/78 (68%)           ig   725 . . . 779   15/56 (27%)   0.027                   35/56 (62%)           ig   813 . . . 881   13/72 (18%)   0.022                   47/72 (65%)           ig   912 . . . 965   16/55 (29%)   2.1e−07                   39/55 (71%)           ig   1003 . . . 1074   14/75 (19%)   0.023                   52/75 (69%)           ig   1191 . . . 1248   13/61 (21%)   0.0048                   40/61 (66%)           ig   1278 . . . 1330   15/55 (27%)   0.16                   34/55 (62%)           ig   1364 . . . 1431   13/72 (18%)   0.00084                   50/72 (69%)                      
 
     Example 15  
      The NOV15 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 15A.  
               TABLE 15A                       NOV15 Sequence Analysis                                                NOV15a, CG51992-05   SEQ ID NO: 419   1511 bp           DNA Sequence   ORF Start: ATG at 339   ORF Stop: TGA at 1203                       AGAGAAGGAGCTAAGAAGCCTGTGGCTACTGAGAAGAGGCCAGCTAAGTGATGCTGGCATGTAGGA AG             CAGGCACACTACTTGTGGATGGGGAGCATGGTGACTGGAGAGACCAGTGAGGGCAATTTGCATCCT TT         GAGGGCAATTTGGTCTCCAAAGAACAGAGTGATCTGGAGGGAGTGACAGCCAAGAGTCAGCCAGAG CA         TCTCAGCCATCCCAGGAATCAGAGAAATCCAGGGAAGCCAGTCTTAATATGATGGAAACATCTCTG AA         CTTCTAAAAGACCAAGGTTGGCGTTTTAGCTCTATTAATTTTACTTCGTCTTGGCCAGAATTCACA   AT           G ACAACAGTGACAGTGACCACAGAAATTCCCCCAAGGGATAAGATGGAAGATAATTCTGCCTTGTATG       AGTCTACGTCCGCTCACATTATTGAAGAAACCGAGTATGTGAAAAAGATTCGAACTACTCTGCAAAAG       ATCAGGACCCAGATGTTTAAAGATGAAATAAGACATGACAGTACAAATCACAAACTAGATGCAAAGCT       GCAAGCCTCCAGAGAAGCAGGAGCAGCAGCTCTGAGAAACGTGGCCCAGAGATTATTTGAAAACTACC       AAACGCAATCTGAAGAAGTGAGAAAGAAGCAGGAGGACAGTAAACAATTACTCCAGGTTAACAAGCTT       GAAAAAGAACAGAAATTGAAACAACATGTTGAAAATCTGAATCAAGTTGCTGAAAAACTTGAAGAAAA       ACACAGTCAAATTACAGAATTGGAGAACCTTGTACAGAGAATGGAAAAGGAAAAGAGAACACTACTAG       AAAGAAAACTGTCTTTGGAAAACAAGCTACTGCAACTCAAATCCAGTGCTACATATGGAAAAAGTTGC       CAGGATCTTCAGAGGGAGATTTCCATTCTCCAGGAGCAGATCTCTCATCTGCAGTTTGTGATTCACTC       CCAACATCAGAACCTGCGCAGTGTCATCCAGGAGATGGAAGGATTAAAAAATAATTTAAAAGAACAAG       ACAAAAGAATTGAAAATCTCAGAGAAAAGGTTAACATACTTGAAGCCCAGAATAAAGAACTAAAAACC       CAGGTAGCACTTTCATCTGAAACTCCTAGGACAAAGGTATCTAAGGCTGTCTCTACAAGTGAATTGAA       GACCGAAGGTGTTTCCCCTTATTTAATGTTGATTAGGTTACGGAAA TGA   ACTGGCTGGATGAAGATCT           GATTTAGAAAGACTGCGTGAGTCTTATTTATTCTCTGAAACACAGCCCAAGTTTCATGTTAAAATGGC           AAAATGCCATTATTTAAATGGAACTTATTACATACCAATGGCTTTGCAAGAAGATGACATTTCAGAAA           ATCAAACAAATCTATATTTAATGGATGGACTCTTCAAAACTTACCAAATAGTTGAAGAAACCAGGTGC           CTTCTCATGATGGAAGACAGATTCTGCTTTAAATTAAAAAAAAAAAAATCTGAATCTTGTTTTCAGAT           TTTTTTTTCTACTGG                                           NOV15a, CG51992-05   SEQ ID NO: 420   288 aa   MW at 33581.0kD           Protein Sequence                     MTTVTVTTEIPPRDKMEDNSALYESTSAHIIEETEYVKKIRTTLQKIRTQMFKDEIRHDSTNHKLDAK           LQASREAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQVAEKLEE       KHSQITELENLVQRMEKEKRTLLERKLSLENKLLQLKSSATYGKSCQDLQREISILQEQISHLQFVIH       SQHQNLRSVIQEMEGLKNNLKEQDKRIENLREKVNILEAQNKELKTQVALSSETPRTKVSKAVSTSEL       KTEGVSPYLMLIRLRK                                     NOV15b, CG51992-01   SEQ ID NO: 421   705 bp           DNA Sequence   ORF Start: at 3   ORF Stop: TGA at 423                       TA CAAAGAATGGAAAAGGAAAAGAGAACACTACTAGAAAGAAAACTGTCTTTGGAAAACAAGCTACTG           CAACTCAAATCCAGTGCTACATATGGAAAAAGTTGCCAGGATCTTCAGAGGGAGATTTCCATTCTCCA       GGAGCAGATCTCTCATCTGCAGTTTGTGATTCACTCCCAACATCAGAACCTGCGCAGTGTCATCCAGG       AGATGGAAGGATTAAAAAATAATTTAAAAGAACAAGACAAAAGAATTGAAAATCTCAGAGAAAAGGTT       AACATACTTGAAGCCCAGAATAAAGAACTAAAAACCCAGGTAGCACTTTCATCTGAAACTCCTAGGAC       AAAGGTATCTAAGGCTGTCTCTACAAGTGAATTGAAGACCGAAGGTGTTTCCCCTTATTTAATGTTGA       TTAGGTTACGGAAA TGA   ACTGGCTGGATGAAGATCTGATTTAGAAAGACTGCGTGAGTCTTATTTATT           CTCTGAAACACACCCCAAGTTTCATGTTAAAATGGCAAAATGCCATTATTTAAATGGAACTTATTACA           TACCAATGGCTTTGCAAGAAGATGACATTTCAGAAAATCAAACAAATCTATATTTAATGGATGGACTC           TTCAAAACTTACCAAATAGTTGAAGAAACCAGGTGCCTTCTCATGATGGAAGACAGATTCTGCTTTAA           ATTAAAAAAAAAAAAATCTGAAAAA                                           NOV15b, CG51992-01   SEQ ID NO: 422   140 aa   MW at 16324.7kD           Protein Sequence                     QRMEKEKRTLLERKLSLENKLLQLKSSATYGKSCQDLQREISILQEQISHLQFVIHSQHQNLRSVIQE           MEGLKNNLKEQDKRIENLREKVNILEAQNKELKTQVALSSETPRTKVSKAVSTSELKTEGVSPYLMLI       RLRK                                     NOV15c, CG51992-02   SEQ ID NO: 423   1080 bp           DNA Sequence   ORF Start: ATG at 45   ORF Stop: TGA at 798                       GTTTAAAGATGAAATGAGACATGACAGTACAAATCACAAACTAG   ATG CAAAGTTTGGATTTGCTTATG           AAAAAGATAAAAGGAAAAGACCTACAGCTCTTAGAAATGAACAAAGAGAATGAAGTATTGAAAATCAA       GCTGCAAGCCTCCAGAGAAGCAGGAGCAGCAGCTCTGAGAAACGTGGCCCAGAGATTATTTGAAAACT       ACCAAACGCAATCTGAAGAAGTGAGAAAGAAGCAGGAGGGCAGTAAACAATTACTCCAGGTTAACAAG       CTTGAAAAAGAACAGAAATTGAAACAACATGTTGAAAATCTGAATCAAGTTGCTGAAAAACTTGAAGA       AAAACACAGTCAAATTACAGAATTGGAGAACCTTGTACAGAGAATGGAAAAGGAAAAGAGAACACTAC       TAGAAAGAAAACTGTCTTTGGAAAACAAGCTACTGCAACTCAAATCCAGTGCTACATATGGAAAAAGT       TGCCAGGATCTTCAGAGGGAGATTTCCATTCTCCAGGAGCAGATCTCTCATCTGCAGTTTGTGATTCA       CTCCCAACATCAGAACCTGCGCAGTGTCATCCAGGAGATGGAAGGATTAAAAAATAATTTAAAAGAAC       AAGACAAAAGAATTGAAAATCTCAGAGAAAAGGTTAACATACTTGAAGCCCAGAATAAAGAACTAAAA       ACCCAGGTAGCACTTTCATCTGAAACTCCTAGGACAAAGGTATCTAAGGCTGTCTCTACAAGTGAATT       GAAGACCGAAGGTGTTTCCCCTTATTTAATGTTGATTAGGTTACGGAAA TGA   ACTGGCTGGATGAAGA           TCTGATTTAGAAAGACTGCGTGAGTCTTATTTATTCTCTGAAACACAGCCCAAGTTTCATGTTAAAAT           GGCAAAATGCCATTATTTAAATGGAACTTATTACATACCAATGGCTTTGCAAGAAGATGACATTTCAG           AAAATCAAACAAATCTATATTTAATGGATGGACTCTTCAAAACTTACCAAATAGTTGAAGAAACCAGG           TGCCTTCTCATGATGGAAGACAGATTCTGCTTTAAATTAAAAAAAAAAAAATCTGAAAAA                                           NOV15c, CG51992-02   SEQ ID NO: 424   251 aa   MW at 29229.5kD           Protein Sequence                     MQSLDLLMKKIKGKDLQLLEMNKENEVLKIKLQASREAGAAALRNVAQRLFENYQTQSEEVRKKQEGS           KQLLQVNKLEKEQKLKQHVENLNQVAEKLEEKHSQITELENLVQRMEKEKRTLLERKLSLENKLLQLK       SSATYGKSCQDLQREISILQEQISHLQFVIHSQHQNLRSVIQEMEGLKNNLKEQDKRIENLREKVNIL       EAQNKELKTQVALSSETPRTKVSKAVSTSELKTEGVSPYLMLIRLRK                                     NOV15d, CG51992-03   SEQ ID NO: 425   1442 bp           DNA Sequence   ORF Start: ATG at 155   ORF Stop: TGA at 1160                       GCCCAGGGGAGGAGCAGCACCGGGACCCCGCGTCGGCTGGGCGCCCCACAAGGGAAGCCAGTCTTAAT               ATGATGGAAACATCTCTGAACTTCTAAAAGACCAAGGTTGGCGTTTTAGCTCTATTAATTTTACTTCG           TCTTGGCCAGAATTCACA   ATG ACAACAGTGACAGTGACCACAGAAATTCCCCCAAGGGATAAGATGGA       AGATAATTCTGCCTTGTATGAGTCTACGTCCGCTCACATTATTGAAGAAACCGAGTATGTGAAAAAGA       TTCGAACTACTCTGCAAAAGATCAGGACCCAGATGTTTAAAGATGAAATAAGACATGACAGTACAAAT       CACAAACTAGATGCAAAGCACTGTGGAAACCTTCAACAGGGCTCTGATTCTGAAATGGATCCTTCTTG       TTGCAGTTTGGATTTGCTTATGAAAAAGATAAAAGGAAAAGACCTACAGCTCTTAGAAATGAACAAAG       AGAATGAAGTATTGAAAATCAAGCTGCAAGCCTCCAGAGAAGCAGGAGCAGCAGCTCTGAGAAACGTG       GCCCAGAGATTATTTGAAAACTACCAAACGCAATCTGAAGAAGTGAGAAAGAAGCAGGAGGACAGTAA       ACAATTACTCCAGGTTAACAAGCTTGAAAAAGAACAGAAATTGAAACAACATGTTGAAAATCTGAATC       AAGTTGCTGAAAAACTTGAAGAAAAACACAGTCAAATTACAGAATTGGAGAACCTTGTACAGAGAATG       GAAAAGGAAAAGAGAACACTACTAGAAAGAAAACTGTCTTTGGAAAACAAGCTACTGCAACTCAAATC       CAGTGCTACATATGGAAAAAGTTGCCAGGATCTTCAGAGGGAGATTTCCATTCTCCAGGAGCAGATCT       CTCATCTGCAGTTTGTGATTCACTCCCAACATCAGAACCTGCGCAGTGTCATCCAGGAGATGGAAGGA       TTAAAAAATAATTTAAAAGAACAAGACAAAAGAATTGAAAATCTCAGAGAAAAGGTTAACATACTTGA       AGCCCAGAATAAAGAACTAAAAACCCAGGTAGCACTTTCATCTGAAACTCCTAGGACAAAGGTATCTA       AGGCTGTCTCTACAAGTGAATTGAAGACCGAAGGTGTTTCCCCTTATTTAATGTTGATTAGGTTACGG       AAA TGA   ACTGGCTGGATGAAGATCTGATTTAGAAAGACTGCGTGAGTCTTATTTATTCTCTGAAACAC           AGCCCAAGTTTCATGTTAAAATGGCAAAATGCCATTATTTAAATGGAACTTATTACATACCAATGGCT           TTGCAAGAAGATGACATTTCAGAAAATCAAACAAATCTATATTTAATGGATGGACTCTTCAAAACTTA           CCAAATAGTTGAAGAAACCAGGTGCCTTCTCATGATGGAAGACAGATTCTGCTTTAAATTAAAAAAAA           AAAAATCTGAAAAA                                           NOV15d, CG51992-03   SEQ ID NO: 426   335 aa   MW at 38869.2kD           Protein Sequence                     MTTVTVTTEIPPRDKMEDNSALYESTSAHIIEETEYVKKIRTTLQKIRTQMFKDEIRHDSTNHKLDAK           HCGNLQQGSDSEMDPSCCSLDLLMKKIKGKDLQLLENNKENEVLKIKLQASREAGAAALRNVAQRLFE       NYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQVAEKLEEKHSQITELENLVQRMEKEKRT       LLERKLSLENKLLQLKSSATYGKSCQDLQREISILQEQISHLQFVIHSQHQNLRSVIQEMEGLKNNLK       EQDKRIENLREKVNILEAQNKELKTQVALSSETPRTKVSKAVSTSELKTEGVSPYLMLIRLRK                                     NOV15e, CG51992-04   SEQ ID NO: 427   1482bp           DNA Sequence   ORF Start: ATG at 195   ORF Stop: TGA at 1200                       GTGTGTGGGTGTCCAGGTGCCTTTCCAGCGGCTTCCCCAGTGGAGTTCCTGGCATCAAGGACATTTCC               TGTAAAAGGGTCCTTGTTGAAGAGGGAAGCCAGTCTTAATATGATGGAAACATCTCTGAACTTCTAAA           AGACCAAGGTTGGCGTTTTAGCTCTATTAATTTTACTTCGTCTTGGCCAGAATTCACA   ATG ACAACAG       TGGCAGTGACCACAGAAATTCCCCCAAGGGATAAGATGGAAGATAATTCTGCCTTGTATGAGTCTACG       TCCGCTCACATTATTGAAGAAACCGAGTATGTGAAAAAGATTCGAACTACTCTGCAAAAGATCAGGAC       CCAGATGTTTAAAGATGAAATAAGACATGACAGTACAAATCACAAACTAGATGCAAAGCACTGTGGAA       ACCTTCAACAGGGCTCTGATTCTGAAATGGATCCTTCTTGTTGCAGTTTGGATTTGCTTATGAAAAAG       ATAAAAGGAAAAGACCTACAGCTCTTAGAAATGAACAAAGAGAATGAAGTATTGAAAATCAAGCTGCA       AGCCTCCAGAGAAGCAGGAGCAGCAGCTCTGAGAAACGTGGCCCAGAGATTATTTGAAAACTACCAAA       CGCAATCTGAAGAAGTGAGAAAGAAGCAGGAGGACAGTAAACAATTACTCCAGGTTAACAAGCTTGAA       AAAGAACAGAAATTGAAACAACATGTTGAAAATCTGAATCAAGTTGCTGAAAAACTTGAAGAAAAACA       CAGTCAAATTACAGAATTGGAGAACCTTGTACAGAGAATGGAAAAGGAAAAGAGAACACTACTAGAAA       GAAAACTGTCTTTGGAAAACAAGCTACTGCAACTCAAATCCAGTGCTACATATGGAAAAAGTTGCCAG       GATCTTCAGAGGGAGATTTCCATTCTCCAGGAGCAGATCTCTCATCTGCAGTTTGTGATTCACTCCCA       ACATCAGAACCTGCGCAGTGTCATCCAGGAGATGGAAGGATTAAAAAATAATTTAAAAGAACAAGACA       AAAGAATTGAAAATCTCAGAGAAAAGGTTAACATACTTGAAGCCCAGAATAAAGAACTAAAAACCCAG       GTAGCACTTTCATCTGAAACTCCTAGGACAAAGGTATCTAAGGCTGTCTCTACAAGTGAATTGAAGAC       CGAAGGTGTTTCCCCTTATTTAATGTTGATTAGGTTACGGAAA TGA   ACTGGCTGGATGAAGATCTGAT           TTAGAAAGACTGCGTGAGTCTTATTTATTCTCTGAAACACAGCCCAAGTTTCATGTTAAAATGGCAAA           ATGCCATTATTTAAATGGAACTTATTACATACCAATGGCTTTGCAAGAAGATGACATTTCAGAAAATC           AAACAAATCTATATTTAATGGATGGACTCTTCAAAACTTACCAAATAGTTGAAGAAACCAGGTGCCTT         +E,UNA CTCATGATGGAAGACAGATTCTGCTTTAAATTAAAAAAAAAAAAATCTGAAAAA                                          NOV15e, CG51992-04   SEQ ID NO: 428   335 aa   MW at 38839.1kD           Protein Sequence                     MTTVAVTTEIPPRDKMEDNSALYESTSAHIIEETEYVKKIRTTLQKIRTQMFKDEIRHDSTNHKLDAK           HCGNLQQGSDSEMDPSCCSLDLLMKKIKGKDLQLLEMNKENEVLKIKLQASREAGAAALRINAQRLFE       NYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQVAEKLEEKHSQITELENLVQRMEKEKRT       LLERKLSLENKLLQLKSSATYGKSCQDLQREISILQEQISHLQFVIHSQHQNLRSVIQEMEGLKNNLK       EQDKRIENLREKVNILEAQNKELKTQVALSSETPRTKVSKAVSTSELKTEGVSPYLMLIRLRK                                     NOV15f, SNP13382486   SEQ ID NO: 429   1511 bp           of CG51992-05,   ORF Start: ATG at 339   ORF Stop: TGA at 1203       DNA Sequence   SNP Pos: 506   SNP Change: A to G                       AGAGAAGGAGCTAAGAAGCCTGTGGCTACTGAGAAGAGGCCAGCTAAGTGATGCTGGCATGTAGGAAG               CAGGCACACTACTTGTGGATGGGGAGCATGGTGACTGGAGAGACCAGTGAGGGCAATTTGCATCCTTT           GAGGGCAATTTGGTCTCCAAAGAACAGAGTGATCTGGAGGGAGTGACAGCCAAGAGTCAGCCAGAGCA           TCTCAGCCATCCCAGGAATCAGAGAAATCCAGGGAAGCCAGTCTTAATATGATGGAAACATCTCTGAA           CTTCTAAAAGACCAAGGTTGGCGTTTTAGCTCTATTAATTTTACTTCGTCTTGGCCAGAATTCACA   AT           G ACAACAGTGACAGTGACCACAGAAATTCCCCCAAGGGATAAGATGGAAGATAATTCTGCCTTGTATG       AGTCTACGTCCGCTCACATTATTGAAAGAAACCGAGTATGTGAAAAAGATTCGAACTACTCTGCAAAG       ATCAGGACCCAGATGTTTAAAGATGAAAT   G   AGACATGACAGTACAAATCACAAACTAGATGCAAAGCT       GCAAGCCTCCAGAGAAGCAGGAGCAGCAGCTCTGAGAAACGTGGCCCAGAGATTATTTGAAAACTACC       AAACGCAATCTGAAGAAGTGAGAAAGAAGCAGGAGGACAGTAAACAATTACTCCAGGTTAACAAGCTT       GAAAAAGAACAGAAATTGAAACAACATGTTGAAAATCTGAATCAAGTTGCTGAAAAACTTGAAGAAAA       ACACAGTCAAATTACAGAATTGGAGAACCTTGTACAGAGAATGGAAAAGGAAAAGAGAACACTACTAG       AAAGAAAACTGTCTTTGGAAAACAAGCTACTGCAACTCAAATCCAGTGCTACATATGGAAAAAGTTGC       CAGGATCTTCAGAGGGAGATTTCCATTCTCCAGGAGCAGATCTCTCATCTGCAGTTTGTGATTCACTC       CCAACATCAGAACCTGCGCAGTGTCATCCAGGAGATGGAAGGATTAAAAAATAATTTAAAAGAACAAG       ACAAAAGAATTGAAAATCTCAGAGAAAAGGTTAACATACTTGAAGCCCAGAATAAAGAACTAAAAACC       CAGGTAGCACTTTCATCTGAAACTCCTAGGACAAAGGTATCTAAGGCTGTCTCTACAAGTGAATTGAA       GACCGAAGGTGTTTCCCCTTATTTAATGTTGATTAGGTTACGGAAA TGA   ACTGGCTGGATGAAGATCT           GATTTAGAAAGACTGCGTGAGTCTTATTTATTCTCTGAAACACAGCCCAAGTTTCATGTTAAAATGGC           AAAATGCCATTATTTAAATGGAACTTATTACATACCAATGGCTTTGCAAGAAGATGACATTTCAGAAA           ATCAAACAAATCTATATTTAATGGATGGACTCTTCAAAACTTACCAAATAGTTGAAGAAACCAGGTGC           CTTCTCATGATGGAAGACAGATTCTGCTTTAAATTAAAAAAAAAAAAATCTGAATCTTGTTTTCAGAT           TTTTTTTTCTACTGG                                           NOV15f, SNP13382486   SEQ ID NO: 430   288 aa   MW at 33599.1kD           of CG51992-05,   SNP Pos: 56       SNP Change:       Protein Sequence           Ile to Met                     MTTVTVTTEIPPRDKMEDNSALYESTSAHIIEETEYVKKIRTTLQKIRTQMFKDE   M   RHDSTNHKLDAK           LQASREAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQVAEKLEE       KHSQITELENLVQRMEKEKRTLLERKLSLENKLLQLKSSATYGKSCQDLQREISILQEQISHLQFVIH       SQHQNLRSVIQEMEGLKNNLKEQDKRIENLREKVNILEAQNKELKTQVALSSETPRTKVSKAVSTSEL       KTEGVSPYLMLIRLRK                                     NOV15g, SNP13382487   SEQ ID NO: 431   1511 bp           of CG51992-05,   ORF Start: ATG at 339   ORF Stop: TGA at 1203       DNA Sequence   SNP Pos: 1360   SNP Change: A to G                       AGAGAAGGAGCTAAGAAGCCTGTGGCTACTGAGAAGAGGCCAGCTAAGTGATGCTGGCATGTAGGAAC               CAGGCACACTACTTGTGGATGGGGAGCATGGTGACTGGAGAGACCAGTGAGGGCAATTTGCATCCTTT           GAGGGCAATTTGGTCTCCAAAGAACAGAGTGATCTGGAGGGAGTGACAGCCAAGAGTCAGCCAGAGCA           TCTCAGCCATCCCAGGAATCAGAGAAATCCAGGGAAGCCAGTCTTAATATGATGGAAACATCTCTGAA           CTTCTAAAAGACCAAGGTTGGCGTTTTAGCTCTATTAATTTTACTTCGTCTTGGCCAGAATTCACA   AT           G ACAACAGTGACAGTGACCACAGAAATTCCCCCAAGGGATAAGATGGAAGATAATTCTGCCTTGTATG       AGTCTACGTCCGCTCACATTATTGAAGAAACCGAGTATGTGAAAAAGATTCGAACTACTCTGCAAAAG       ATCAGGACCCAGATGTTTAAAGATGAAATAAGACATGACAGTACAAATCACAAACTAGATGCAAAGCT       GCAAGCCTCCAGAGAAGCAGGAGCAGCAGCTCTGAGAAACGTGGCCCAGAGATTATTTGAAAACTACC       AAACGCAATCTGAAGAAGTGAGAAAGAAGCAGGAGGACAGTAAACAATTACTCCAGGTTAACAAGCTT       GAAAAAGAACAGAAATTGAAACAACATGTTGAAAATCTGAATCAAGTTGCTGAAAAACTTGAAGAAAA       ACACAGTCAAATTACAGAATTGGAGAACCTTGTACAGAGAATGGAAAAGGAAAAGAGAACACTACTAG       AAAGAAAACTGTCTTTGGAAAACAAGCTACTGCAACTCAAATCCAGTGCTACATATGGAAAAAGTTGC       CAGGATCTTCAGAGGGAGATTTCCATTCTCCAGGAGCAGATCTCTCATCTGCAGTTTGTGATTCACTC       CCAACATCAGAACCTGCGCAGTGTCATCCAGGAGATGGAAGGATTAAAAAATAATTTAAAAGAACAAG       ACAAAAGAATTGAAAATCTCAGAGAAAAGGTTAACATACTTGAAGCCCAGAATAAAGAACTAAAAACC       CAGGTAGCACTTTCATCTGAAACTCCTAGGACAAGGTATCTAAAGGCTGTCTCTACAAGTGAATTGAA       GACCGAAGGTGTTTCCCCTTATTTAATGTTGATTAGGTTACGGAAA TGA   ACTGGCTGGATGAAGATCT           GATTTAGAAAGACTGCGTGAGTCTTATTTATTCTCTGAAACACAGCCCAAGTTTCATGTTAAAATGGC           AAAATGCCATTATTTAAATGGAACTTATTACATACCAATGGCTTTGCAAGAAGATGACATTTCAGAAG           ATCAAACAAATCTATATTTAATGGATGGACTCTTCAAAACTTACCAAATAGTTGAAGAAACCAGGTGC           CTTCTCATGATGGAAGACAGATTCTGCTTTAAATTAAAAAAAAAAAAATCTGAATCTTGTTTTCAGAT           TTTTTTTTCTACTGG                                           NOV15g, SNP13382487   SEQ ID NO: 432   1288 aa   MW at 33581.0kD           of CG51992-05,           SNP Change:       Protein Sequence           no change                     MTTVTVTTEIPPRDKMEDNSALYESTSAHIIEETEYVKKIRTTLQKIRTQMFKDEIRHDSTNBKLDAK           LQASREAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQVAEKLEE       KHSQITELENLVQRMEKEKRTLLERKLSLENKLLQLKSSATYGKSCQDLQREISILQEQISHLQFVIH       SQHQNLRSVIQEMEGLKNNLKEQDKRIENLREKVNILEAQNKELKTQVALSSETPRTKVSKAVSTSEL       KTEGVSPYLMLIRLRK                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 15B.  
               TABLE 15B                       Comparison of the NOV15 protein sequences.                                            NOV15a   MTTVTVTTEIPPRDKMEDNSALYESTSAHIIEETEYVKKIRTTLQKIRTQMFKDEIRHDS           NOV15b   ------------------------------------------------------------       NOV15c   ------------------------------------MQSLDLLMKKIKGKDLQ-LLEMNK       NOV15d   MTTVTVTTEIPPRDKMEDNSALYESTSAHIIEETEYVKKIRTTLQKIRTQMFKDEIRHDS       NOV15e   MTTVAVTTEIPPRDKMEDNSALYESTSAHIIEETEYVKKIRTTLQKIRTQMFKDEIRHDS               NOV15a   TNHKLDAK-----------------------------------------------LQASR       NOV15b   ------------------------------------------------------------       NOV15c   ENEVLKIK-----------------------------------------------LQASR       NOV15d   TNHKLDAKHCGNLQQGSDSEMDPSCCSLDLLMKKIKGKDLQLLEMNKENEVLKIKLQASR       NOV15e   TNHKLDAKHCGNLQQGSDSEMDPSCCSLDLLMKKIKGKDLQLLEMNKENEVLKIKLQASR               NOV15a   EAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQVAEK       NOV15b   ------------------------------------------------------------       NOV15c   EAGAAALRNVAQRLFENYQTQSEEVRKKQEGSKQLLQVNKLEKEQKLKQHVENLNQVAEK       NOV15d   EAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQVAEK       NOV15e   EAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQVAEK               NOV15a   LEEKHSQITELENLVQRMEKEKRTLLERYLSLENKLLQLKSSATYGKSCQDLQREISILQ       NOV15b   ---------------QRMEKEKRTLLERKLSLENKLLQLKSSATYGKSCQDLQREISILQ       NOV15c   LEEKHSQITELENLVQRMEKEKRTLLERKLSLENKLLQLKSSATYGKSCQDLQREISILQ       NOV15d   LEEKHSQITELENLVQRMEKEKRTLLERKLSLENKLLQLKSSATYGKSCQDLQREISILQ       NOV15e   LEEKHSQITELENLVQRMEKEKRTLLERKLSLENKLLQLKSSATYGKSCQDLQREISILQ               NOV15a   EQISHLQFVIHSQHQNLRSVIQEMEGLKNNLKEQDKRIENLREKVNILEAQNKELKTQVA       NOV15b   EQISHLQFVIHSQHQNLRSVIQEMEGLKNNLKEQDKRIENLREKVNILEAQNKELKTQVA       NOV15c   EQISHLQFVIHSQHQNLRSVIQEMEGLKNNLKEQDKRIENLREKVNILEAQNKELKTQVA       NOV15d   EQISHLQFVIHSQHQNLRSVIQEMEGLKNNLKEQDKRIENLREKVNILEAQNKELKTQVA       NOV15e   EQISHLQFVIHSQHQNLRSVIQEMEGLKNNLKEQDKRIENLREKVNILEAQNKELKTQVA               NOV15a   LSSETPRTKVSKAVSTSELKTEGVSPYLMLIRLRK       NOV15b   LSSETPRTKVSKAVSTSELKTEGVSPYLMLIRLRK       NOV15c   LSSETPRTKVSKAVSTSELKTEGVSPYLMLIRLRK       NOV15d   LSSETPRTKVSKAVSTSELKTEGVSPYLMLIRLRK       NOV15e   LSSETPRTKVSKAVSTSELKTEGVSPYLMLIRLRK               NOV15a   (SEQ ID NO: 420)       NOV15b   (SEQ ID NO: 422)       NOV15c   (SEQ ID NO: 424)       NOV15d   (SEQ ID NO: 426)       NOV15e   (SEQ ID NO: 428)                  
 
      Further analysis of the NOV15a protein yielded the following properties shown in Table 15C.  
               TABLE 15C                       Protein Sequence Properties NOV15a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 9; pos. chg 0; neg. chg 1           H-region:   length 3; peak value 0.00           PSG score:   −4.40                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −11.91           possible cleavage site: between 49 and 50                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 0           number of TMS(s) . . . fixed           PERIPHERAL Likelihood = 9.07 (at 189)           ALOM score: 9.07 (number of TMSs: 0)       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   1   Hyd Moment(75):   1.56           Hyd Moment(95):   1.30   G content:   0           D/E content:   2   S/T content:   5                         Score: −5.82       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 17.4%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 94.1       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions        76 A   0.56        77 A   0.56        78 A   0.56        79 L   0.56        80 R   0.56        81 N   0.59        82 V   0.67        83 A   0.67        84 Q   0.67        85 R   0.67        86 L   0.67        87 F   0.67        88 E   0.67        89 N   0.67        90 Y   0.67        91 Q   0.67        92 T   0.67        93 Q   0.80        94 S   0.80        95 E   0.80        96 E   0.80        97 V   0.80        98 R   0.80        99 K   0.81       100 K   0.81       101 Q   0.81       102 E   0.81       103 D   0.81       104 S   0.81       105 K   0.81       106 Q   0.81       107 L   0.86       108 L   0.98       109 Q   0.98       110 V   0.98       111 N   0.98       112 K   0.98       113 L   0.98       114 E   0.98       115 K   0.98       116 E   0.99       117 Q   0.99       118 K   0.99       119 L   0.99       120 K   0.99       121 Q   0.99       122 H   0.99       123 V   0.99       124 E   1.00       125 N   1.00       126 L   1.00       127 N   1.00       128 Q   1.00       129 V   1.00       130 A   1.00       131 E   1.00       132 K   1.00       133 L   1.00       134 E   1.00       135 E   1.00       136 K   1.00       137 H   1.00       138 S   1.00       139 Q   1.00       140 I   1.00       141 T   1.00       142 E   1.00       143 L   1.00       144 E   1.00       145 N   1.00       146 L   1.00       147 V   1.00       148 Q   1.00       149 R   1.00       150 M   1.00       151 E   1.00       152 K   1.00       153 E   1.00       154 K   1.00       155 R   1.00       156 T   1.00       157 L   1.00       158 L   1.00       159 E   1.00       160 R   1.00       161 K   1.00       162 L   1.00       163 S   1.00       164 L   1.00       165 E   1.00       166 N   1.00       167 K   1.00       168 L   1.00       169 L   1.00       170 Q   1.00       171 L   1.00       172 K   1.00       173 S   1.00       174 S   1.00       175 A   1.00       176 T   0.99       177 Y   0.88       178 G   0.83       179 K   0.83       180 S   0.83       181 C   0.83       182 Q   0.83       183 D   0.83       184 L   0.83       185 Q   0.83       186 R   0.83       187 E   0.83       188 I   0.83       189 S   0.83       190 I   0.83       191 L   0.83       192 Q   0.83       193 E   0.83       194 Q   0.83       195 I   0.83       196 S   0.83       197 H   0.83       198 L   0.83       199 Q   0.83       200 F   0.62       201 V   0.62       202 I   0.87       203 H   0.87       204 S   0.99       205 Q   0.99       206 H   1.00       207 Q   1.00       208 N   1.00       209 L   1.00       210 R   1.00       211 S   1.00       212 V   1.00       213 I   1.00       214 Q   1.00       215 E   1.00       216 M   1.00       217 E   1.00       218 G   1.00       219 L   1.00       220 K   1.00       221 N   1.00       222 N   1.00       223 L   1.00       224 K   1.00       225 E   1.00       226 Q   1.00       227 D   1.00       228 K   1.00       229 R   1.00       230 I   1.00       231 E   1.00       232 N   1.00       233 L   1.00       234 R   1.00       235 E   1.00       236 K   1.00       237 V   1.00       238 N   1.00       239 I   1.00       240 L   1.00       241 E   1.00       242 A   1.00       243 Q   1.00       244 N   1.00       245 K   1.00       246 E   1.00       247 L   1.00       248 K   1.00       249 T   1.00       250 Q   1.00       251 V   1.00       252 A   1.00       253 L   1.00       254 S   1.00       255 S   1.00       256 E   1.00       257 T   1.00           total: 182 residues                 Final Results (k = 9/23):                         69.6%: nuclear           13.0%: cytoplasmic            8.7%: peroxisomal            4.3%: cytoskeletal            4.3%: mitochondrial                 &gt;&gt; prediction for CG51992-05 is nuc (k = 23)                  
 
      A search of the NOV15a protein against the Geneseq database, a proprietary se that contains sequences published in patents and patent publication, yielded homologous proteins shown in Table 15D.  
               TABLE 15D                          Geneseq Results for NOV15a                                         NOV15a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value                                             ABB77426   Human tumour marker protein se57-1 -   1 . . . 288   288/335   (85%)   e−151             Homo sapiens , 335 aa. [WO200238803-   1 . . . 335   288/335   (85%)           A2, 16-MAY-2002]       AAU08663   Human NOV7 protein -  Homo sapiens ,   1 . . . 288   288/335   (85%)   e−151           335 aa. [WO200168851-A2, 20-SEP-   1 . . . 335   288/335   (85%)           2001]       AAU08662   Human NOV6 protein -  Homo sapiens ,   1 . . . 288   287/335   (85%)   e−150           335 aa. [WO200168851-A2, 20-SEP-   1 . . . 335   287/335   (85%)           2001]       AAU08661   Human NOV5 protein -  Homo sapiens ,   62 . . . 288    222/227   (97%)   e−117           251 aa. [WO200168851-A2, 20-SEP-   25 . . . 251    222/227   (97%)           2001]       ABG79634   Human novel secreted protein SECP10,   43 . . . 258    67/221   (30%)   1e−21            Incyte ID No. 7939381CD1 -  Homo     202 . . . 415    125/221   (56%)             sapiens , 466 aa. [WO200262841-A2,           15-AUG-2002]                  
 
      In a BLAST search of public sequence databases, the NOV15a protein was found to have homology to the proteins shown in the BLASTP data in Table 15E.  
               TABLE 15E                          Public BLASTP Results for NOV15a                                         NOV15a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             Q9H2F9   CTCL tumor antigen se57-1 -   1 . . . 288   288/335   (85%)    e−150             Homo sapiens  (Human), 335 aa.   1 . . . 335   288/335   (85%)       Q8BVC4   Similar to CTCL tumor antigen   1 . . . 288   213/333   (63%)    e−106           SE57-1 -  Mus musculus  (Mouse),   1 . . . 333   241/333   (71%)           333 aa.       AAH46343   Hypothetical protein -  Mus     1 . . . 155   102/200   (51%)   3e−43             musculus  (Mouse), 242 aa.   1 . . . 200   120/200   (60%)       Q96NF5   Hypothetical protein FLJ30973 -   43 . . . 258    67/221   (30%)   5e−21             Homo sapiens  (Human), 466 aa.   202 . . . 415    125/221   (56%)       A40809   enamelin, 44K - bovine, 389 aa.   22 . . . 261    61/275   (22%)   6e−15               39 . . . 309    131/275   (47%)                  
 
      PFam analysis predicts that the NOV15a protein contains the domains shown in the Table 15F.  
               TABLE 15F                       Domain Analysis of NOV15a                                                        Pfam   NOV15a   Identities/   Expect           Domain   Match Region   Similarities   Value                   for the                   Matched Region                      
 
     Example 16  
      The NOV16 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 16A.  
               TABLE 16A                       NOV16 Sequence Analysis                                                NOV16a, CG52171-04   SEQ ID NO: 433   2403 bp           DNA Sequence   ORF Start: ATG at 81   ORF Stop: TGA at 2292                     GGCACGAGAAGTTAAGCTGAAGACCGAAGCAAGAGCTGGTTCAGGTGGCAGCCACAGCAGCCTCAGGC           ACCTCAGCAACTATGCCCTCCTGCCCAGACTCTGATAATAGCTGGGTGCTTGCTGGCTCCGAGAGCCT       GCCAGTGGAGACACTGGGCCCGGCATCCAGGATGGACCCAGAATCTGAGAGAGCCCTGCAGGCCCCTC       ACAGCCCCTCCAAGACAGATGGGAAAGAATTAGCTGGGACCATGGATGGAGAAGGGACGCTCTTCCAG       ACTGAAAGCCCTCAGTCTGGCAGCATTCTAACAGAGGAGACTGAGGTCAAGGGCACCCTGGAAGGTGA       TGTTTGTGGTGTGGAGCCTCCTGGCCCAGGAGACACAGTAGTCCAGGGAGACCTGCAGGAGACCACCG       TGGTGACAGGCCTGGGACCAGACACACAGGACCTGGAAGGCCAGAGCCCTCCACAGAGCCTGCCTTCA       ACCCCCAAAGCAGCTTGGATCAGGGAGGAGGGCCGCTGCTCCAGCAGTGACGATGACACCGACGTGGA       CATGGAGGGTCTGCGGAGACGGCGGGGCCGGGAGGCCGGCCCACCTCAGCCCATGGTGCCCCTGGCTG       TGGAGAACCAGGCTGGGGGTGAGGGTGCAGGCGGGGAGCTGGGCATCTCCCTCAACATGTGCCTCCTT       GGGGCCCTGGTTCTGCTTGGCCTGGGGGTCCTCCTCTTCTCAGGTGGCCTCTCAGAGTCTGAGACTGG       GCCCATGGAGGAAGTGGAGCGGCAGGTCCTCCCAGACCCCGAGGTGCTGGAAGCTGTGGGGGACAGGC       AGGATGGGCTAAGGGAACAGCTGCAGGCCCCAGTGCCTCCTGACAGTGTCCCCAGCCTGCAAAACATG       GGTCTTCTGCTGGACAAGCTGGCCAAGGAGAACCAGGACATCCGGCTGCTGCAGGCCCAGCTGCAGGC       CCAAAAGGAAGAGCTTCAGAGCCTGATGCACCAGCCCAAAGGGCTAGAGGAGGAGAATGCCCAGCTCC       GGGGGGCTCTGCAGCAGGGCGAAGCCTTCCAGCGGGCTCTGGAGTCAGAGCTGCAGCAGCTGCGGGCC       CGGCTCCAGGGGCTGGAGGCCGACTGTGTCCGGGGCCCAGATGGGGTGTGCCTCAGTGGGGATAGAGG       CCCACAGGGTGACAAGGCCATCAGGGAGCAAGGCCCCAGGGAGCAGGAGCCAGAACTCAGCTTCCTGA       AGCAGAAGGAACAGCTGGAGGCTGAGGCACAGGCATTAAGGCAAGAGTTAGAGAGGCAGCGACGGCTG       CTGGGGTCTGTACAGCAGGATCTGGAGAGGAGCTTGCAGGATGCCAGCCGCGGGGACCCAGCTCATGC       TGGCTTGGCTGAGCTGGGCCACAGATTGGCCCAGAAACTGCAGGGCCTGGAGAACTGGGGCCAGGACC       CTGGGGTCTCTGCCAATGCCTCAAAGGCCTGGCACCAGAAGTCCCACTTCCAGAATTCTAGGGAGTGG       AGTGGAAAGGAAAAGTGGTGGGATGGGCAGAGAGACCGGAAGGCTGAGCACTGGAAACATAAGAAGGA       AGAATCTGGCCGGGAAAGGAAGAAGAACTGGGGAGGTCAGGAGGACAGGGAGCCAGCAGGAAGGTGGA       AGGAGGGCAGGCCAAGGGTGGAGGAGTCGGGGAGCAAGAAGGAGGGCAAGCGACAGGGCCCGAAGGAA       CCCCCAAGGAAAAGTGGTAGCTTCCACTCCTCTGGAGAAAAGCAGAAGCAACCTCGGTGGAGGGAAGG       GACTAAGGACAGCCATGACCCCCTGCCATCCTGGGCAGAGCTGTTGAGGCCCAAGTACCGGGCACCCC       AGGGCTGCTCAGGTGTGGACGAGTGTGCCCGGCAGGAGGGCTTGACTTTCTTTGGCACAGAGCTAGCC       CCAGTGCGGCAACAGGAGCTGGCCTCTCTGCTAAGAACATACTTGGCACGGCTGCCCTGGGCTGGGCA       GCTGACCAAGGAGCTACCCCTCTCACCTGCTTTCTTTGGTGAGGATGGCATCTTCCGTCATGACCGCC       TCCGCTTCCGGGATTTTGTGGATGCCCTGGAGGACAGCTTGGAGGAGGTGGCTGTGCAACAGACAGGT       GATGATGATGAAGTAGATGACTTTGAGGACTTCATCTTCAGCCACTTCTTTGGAGACAAAGCACTGAA       GAAGAGGCCTCTTCCTCCCCACAGGTCAGGGAAGAAGGACAAGCACTCACAGAGCCCAAGAGCTGCGG       GGCCCAGGGAGGGGCACAGCCATAGCCACCACCACCACCACCGGGGC TGA   CACCCTGCCCCACAGGGA           ATGGCCTTGGCCTGGCCCAGCCCAAGATCCCAGCGTTATCCAACTCCTGGAGGGTGGACTCTGTCCTG           GCTTGTTTGGTGTCCTCAGATAT                                           NOV16a, CG52171-04   SEQ ID NO: 434   737 aa   MW at 81398.4kD           Protein Sequence                     MASCPDSDNSWVLAGSESLPVETLGPASRMDPESEEALQAPHSPSKTDGKELAGTMDGEGTLFQTESP           QSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKA       AWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALV       LLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLL       DKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQG       LEADCVRGPDGVCLSGDRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSV       QQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKE       KWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRK       SGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTEIAPVRQ       QELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDE       VDDFEDFIFSHFFGDKALKKRPLPPHRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG                                     NOV16b, CG52171-01   SEQ ID NO: 435   2739 bp           DNA Sequence   ORF Start: ATG at 670   ORF Stop: TGA at 2275                       CTGCAACAAGTTAAGCTGAAGACCGAAGCAAGAGCTGGTTCAGGTGGCAGCCACAGCAGCCTCAGGGA               CCTCAGCAACTATGGCCTCCTGCCCAGACTCTGATAATAGCTGGGTGCTTGCTGGCTCCGAGAGCCTC           CCAGTGGAGACACTGGGCCCGGCATCCAGGATGGACCCAGAATCTGAGAGAGCCCTGCAGGCCCCTCA           CAGCCCCTCCAAGACAGATGGGAAAGAATTAGCTGGGACCATGGATGGAGAAGGGACGCGCTTCCAGA           CTGAAAGCCCTCAGTCTGGCAGCATTCTAACAGAGGAGACTGAGGTCAAGGGCACCCTGGAAGGTGAT           GTTTGTGGTGTGGAGCCTCCTGGCCCAGGAGACACAGTAGTCCAGGGAGACCTGCAGGAGACCACCGT           GGTGACAGGCCTGGGACCAGACACACAGGACCTGGAAGGCCAGAGCCCTCCACAGAGCCTGCCTTCAA           CCCCCAAAGCAGCTTGGATCAGGGAGGAGGGCCGCTGCTCCAGCAGTGACGATGACACCGACGTGGAC           ATGGAGGGTCTGCGGAGACGGCGGGGCCGGGAGGCCGGCCCACCTCAGCCCATGGTGCCCCTGGCTGT           GGAGAACCAGGCTGGGGGTGAGGGTGCAGGCGGGGAGCTGGGCATTTTCCCCTCAAC   ATG TGCCTCCT       TGGGGCCCTGGTTCTGCTTGGCCTGGGGGTCCTCCTCTTCTCAGGTGGCCTCTCAGAGTCTGAGACTG       GGCCCATGGAGGAAGTGGAGCGGCAGGTCCTCCCAGACCCCGAGGTGCTGGAAGCTGTGGGGGACAGG       CAGGATGGGCTAAGGGAACAGCTGCAGGCCCCAGTGCCTCCTGACAGTGTCCCCAGCCTGCAAAACAT       GGGTCTTCTGCTGGACAAGCTGGCCAAGGAGAACCAGGACATCCGGCTGCTGCAGGCCCAGCTGCAGG       CCCAAAAGGAAGAGCTTCAGAGCCTGATGCACCAGCCCAAAGGGCTAGAGGAGGAGAATGCCCAGCTC       CGGGGGGCTCTGCAGCAGGGCGAAGCCTTCCAGCGGGCTCTGGAGTCAGAGCTGCAGCAGCTGCGGGC       CCGGCTCCAGGGGCTGGAGGCCGACTGTGTCCGGGGCCCAGATGGGGTGTGCCTCAGTGGGGGTAGAG       GCCCACAGGGTGACAAGGCCATCAGGGAGCAAGGCCCCAGGGAGCAGGAGCCAGAACTCAGCTTCCTG       AAGCAGAAGGAACAGCTGGAGGCTGAGGCACAGGCATTAAGGCAAGAGTTAGAGAGGCAGCGACGGCT       GCTGGGGTCTGTACAGCAGGATCTGGAGAGGAGCTTGCAGGATGCCAGCCGCGGGGACCCAGCTCATG       CTGGCTTGGCTGAGCTGGGCCACAGATTGGCCCAGAAACTGCAGGGCCTGGAGAACTGGGGCCAGGAC       CCTGGGGTCTCTGCCAATGCCTCAAAGGCCTGGCACCAGAAGTCCCACTTCCAGAATTCTAGGGAGTG       GAGTGGAAAGGAAAAGTGGTGGGATGGGCAGAGAGACCGGAAGGCTGAGCACTGGAAACATAAGAAGG       AAGAATCTGGCCGGGAAAGGAAGAAGAACTGGGGAGGTCAGGAGGACAGGGAGCCAGCAGGAAGGTGG       AAGGAGGGCAGGCCAAGGGTGGAGGAGTCGGGGAGCAAGAAGGAGGGCAAGCGACAGGGCCCGAAGGA       ACCCCCAAGGAAAAGTGGTAGCTTCCACTCCTCTGGAGAAAAGCAGAAGCAACCTCGGTGGAGGGAAG       GGACTAAGGGCAGCCATGACCCCCTGCCATCCTGGGCAGAGCTGTTGAGGCCCAAGTACCGGGCACCC       CAGGGCTGCTCAGGTGTGGACGAGTGTGCCCGGCAGGAGGGCCTGACTTTCTTTGGCACAGAGCTAGC       CCCAGTGCGGCAACAGGAGCTGGCCTCTCTGCTAAGAACATACTTGGCACGGCTGCCCTGGGCTGGGC       AGCTGACCAAGGAGCTACCCCTCTCACCTGCTTTCTTTGGTGAGGATGGCATCTTCCGTCATGACCGC       CTCCGCTTCCGGGATTTTGTGGATGCCCTGGAGGACAGCTTGGAGGAGGTGGCTGTGCAACAGACAGG       TGATGATGATGAAGTAGATGACTTTGAGGACTTCATCTTCAGCCACTTCTTTGGAGACAAAGCACTGA       AGAAGAGGTCAGGGAAGAAGGACAAGCACTCACAGAGCCCAAGAGCTGCGGGGCCCAGGGAGGGGCAC       AGCCATAGCCACCACCACCACCACCGGGGC TGA   CACCCTGCCCCACAGGGAATGGCCTTGGCCTGGCC           CAGCCCAAGATCCCAGCGTTATCTAACTCCTGGAGGGTGGACTCTGTCCTGGCTTGTTTGGTGTCCTC           AGATATCTTTCACACAGTAGAGCAAAATCACCAGCCCTGCACTGATGTCACTTTATGTAGAAAAAGGC           CTTAGCTGGACCTGCGTTGCCGTCTATGCAAATGCATGCAAATACTCCAGGCCCTGGGATGTGGGCTT           GTGTTTTGTCACTGTGAAGGGGGAGATGGGAGAGGAGCCTGTTTTGGGGTGGGGTCTGGGGAAGGCAA           TCTGATTCTGAAGCTAAAGAGCTTTCATCCTCTTGAGTGTATGTCCCCATAGTGGGCCCCTTGACCCA           CATGCTGACCGGTGCCTTGGGATTTGACTAGAGTTGCTGCTTCCAAACCTAACAAAACCCCAGGGTAA           GTCCTCGTGCTGGGCCTCG                                           NOV16b, CG52171-01   SEQ ID NO: 436   535 aa   MW at 60290.7kD           Protein Sequence                     MCLLGALVLLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPS           LQNMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQ       QLRARLQGLEADCVRGPDGVCLSGGRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELER       QRRLLGSVQQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQN       SREWSGKEKWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQ       GPKEPPRKSGSFHSSGEKQKQPRWREGTKGSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFG       TELAPVRQQELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAV       QQTGDDDEVDDFEDFIFSHFFGDKALKKRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG                                     NOV16c, CG52171-02   SEQ ID NO: 437   1665 bp           DNA Sequence   ORF Start: ATG at 77   ORF Stop: TGA at 1388                       CAACAAGTTAAGCTGAAGACCGAAGCAAGAGCTGGTTCAGGTGGCAGCCACAGCAGCCTCAGGGACCT               CAGCAACT   ATG GCCTCCTGCCCAGACTCTGATAATAGCTGGGTGCTTGCTGGCTCCGAGAGCCTGCCA       GTGGAGACACTGGGCCCGGCATCCAGGATGGACCCAGAATCTGAGAGAGCCCTGCAGGCCCCTCACAG       CCCCTCCAAGACAGATGGGAAAGAATTAGCTGGGACCATGGATGGAGAAGGGACGCTCTTCCAGACTG       AAAGCCCTCAGTCTGGCAGCATTCTAACAGAGGAGACTGAGGTCAAGGGCACCCTGGAAGGTGATGTT       TGTGGTGTGGAGCCTCCTGGCCCAGGAGACACAGTAGTCCAGGGAGACCTGCAGGAGACCACCGTGGT       GACAGGCCTGGGACCAGACACACAGGACCTGGAAGGCCAGAGCCCTCCACAGAGCCTGCCTTCAACCC       CCAAAGCAGCTTGGATCAGGGAGGAGGGCCGCTGCTCCAGCAGTGACGATGACACCGACGTGGACATG       GAGGGTCTGCGGAGACGGCGGGGCCGGGAGGCCGGCCCACCTCAGCCCATGGTGCCCCTGGCTGTGGA       GAACCAGGCTGGGGGTGAGGGTGCAGGCGGGGAGCTGGGCATCTCCCTCAACATGTGCCTCCTTGGGG       CCCTGGGTCTGCTTGGCCTGGGGGTCCTCCTCTTCTCAGGTGGCCTCTCAGAGTCTGAGACTGGGCCC       ATGGAGGAAGTGGAGCGGCAGGTCCTCCCAGACCCCGAGGTGCTGGAAGCTGTGGGGGACAGGCAGGA       TGGGCTAAGGGAACAGCTGCAGGCCCCAGTGCCTCCTGACAGTGTCCCCAGCCTGCAAAACATGGGTC       TTCTGCTGGACAAGCTGGCCAAGGAGAACCAGGACATCCGGCTGCTGCAGGCCCAGCTGCAGGCCCAA       AAGGAAGAGCTTCAGAGCCTGATGCACCAGCCCAAAGGGCTAGAGGAGGAGAATGCCCAGCTCCGGGG       GGCTCTGCAGCAGGGCGAAGCCTTCCAGCGGGCTCTGGAGTCAGAGCTGCAGCAGCTGCGGGCCCGGC       TCCAGGGGCTGGAGGCCGACTGTGTCCGGGGCCCAGATGGGGATGGCATCTTCCGTCATGACCGCCTC       CGCTTCCGGGATTTTGTGGATGCCCTGGAGGACAGCTTGGAGGAGGTGGCTGTGCAACAGACAGGTGA       TGATGATGAAGTAGATGACTTTGAGGACTTCATCTTCAGCCACTTCTTTGGAGACAAAGCACTGAAGA       AGAGGTCAGGGAAGAAGGACAAGCACTCACAGAGCCCAAGAGCTGCGGGGCCCAGGGAGGGGCACAGC       CATAGCCACCACCACCACCACCGGGGC TGA   CACCCTGCCCCACAGGGAATGGCCTTGGCCTGGCCCAG           CCCAAGATCCCAGCGTTATCTAACTCCTGGAGGGTGGACTCTGTCCTGGCTTGTTTGGTGTCCTCAGA           TATCTTTCACACAGTAGAGCAAAATCACCAGCCCTGCACTGATGTCACTTTATGTAGAAAAAGGCCTT           AGCTGGACCTGCGTTGCCGTCTATGCAAATGCATGCAAATACTCCAGGCCCTGGGATGTGGGCTTGTG           TTTTGTCACTGTGAAGGGGGAGATGGGAGAGGA                                           NOV16c, CG52171-02   SEQ ID NO: 438   437 aa   MW at 47136.5kD           Protein Sequence                     MASCPDSDNSWVLAGSESLPVETLGPASRMDPESEHALQAPHSPSKTDGKELAGTMDGEGTLFQTESP           QSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKA       AWIREEGRCSSSDDDTDVDMEGLPRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALG       LLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLL       DKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLPARLQG       LEADCVRGPDGDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDEVDDFEDFIFSHFFGDKALKKRS       GKKDKHSQSPPAAGPREGHSHSHHHHHRG                                     NOV16d, CG52171-03   SEQ ID NO: 439   2104 bp           DNA Sequence   ORF Start: ATG at 76   ORF Stop: at 2104                       AACAAGTTAAGCTGAAGACCGAAGCAAGAGCTGGTTCAGGTGGCAGCCACAGCAGCCTCAGGGACCTC               AGCAACT   ATG GCCTCCTGCCCAGACTCTGATAATAGCTGGGTGCTTGCTGGCTCCGAGAGCCTGCCAG       TGGAGACACTGGGCCCGGCATCCAGGATGGACCCAGAATCTGAGAGAGCCCTGCAGGCCCCTCACAGC       CCCTCCAAGACAGATGGGAAAGAATTAGCTGGGACCATGGATGGAGAAGGGACGCTCTTCCAGACTGA       AAGCCCTCAGTCTGGCAGCATTCTAACAGAGGAGACTGAGGTCAAGGGCACCCTGGAAGGTGATGTTT       GTGGTGTGGAGCCTCCTGGCCCAGGAGACACAGTAGTCCAGGGAGACCTGCAGGAGACCACCGTGGTG       ACAGGCCTGGGACCAGACACACAGGACCTGGAAGGCCAGAGCCCTCCACAGAGCCTGCCTTCAACCCC       CAAAGCAGCTTGGATCAGGGAGGAGGGCCGCTGCTCCAGCAGTGACGATGACACCGACGTGGACATGG       AGGGTCTGCGGAGACGGCGGGGCCGGGAGGCCGGCCCACCTCAGCCCATGGTGCCCCTGGCTGTGGAG       AACCAGGCTGGGGGTGAGGGTGCAGGCGGGGAGCTGGGCATCTCCCTCAACATGTGCCTCCTTGGGGC       CCTGGGTCTGCTTGGCCTGGGGGTCCTCCTCTTCTCAGGTGGCCTCTCAGAGTCTGAGACTGGGCCCA       TGGAGGAAGTGGAGCGGCAGGTCCTCCCAGACCCCGAGGTGCTGGAAGCTGTGGGGGACAGGCAGGAT       GGGCTAAGGGAACAGCTGCAGGCCCCAGTGCCTCCTGACAGTGTCCCCAGCCTGCAAAACATGGGTCT       TCTGCTGGACAAGCTGGCCAAGGAGAACCAGGACATCCGGCTGCTGCAGGCCCAGCTGCAGGCCCAAA       AGGAAGAGCTTCAGAGCCTGATGCACCAGCCCAAAGGGCTAGAGGAGGAGAATGCCCAGCTCCGGGGG       GCTCTGCAGCAGGGCGAAGCCTTCCAGCGGGCTCTGGAGTCAGAGCTGCAGCAGCTGCGGGCCCGGCT       CCAGGGGCTGGAGGCCGACTGTGTCCGGGGCCCAGATGGGGTGTGCCTCAGTGGGGGTAGAGGCCCAC       AGGGTGACAAGGCCATCAGGGAGCAAGGCCCCAGGGAGCAGGAGCCAGAACTCAGCTTCCTGAAGCAG       AAGGAACAGCTGGAGGCTGAGGCACAGGCATTAAGGCAAGAGTTAGAGAGGCAGCGACGGCTGCTGGG       GTCTGTACAGCAGGATCTGGAGAGGAGCTTGCAGGATGCCAGCCGCGGGGACCCAGCTCATGCTGGCT       TGGCTGAGCTGGGCCACAGATTGGCCCAGAAACTGCAGGGCCTGGAGAACTGGGGCCAGGACCCTGGG       GTCTCTGCCAATGCCTCAAAGGCCTGGCACCAGAAGTCCCACTTCCAGAATTCTAGGGAGTGGAGTGG       AAAGGAAAAGTGGTGGGATGGGCAGAGAGACCGGAAGGCTGAGCACTGGAAACATAAGAAGGAAGAAT       CTGGCCGGGAAAGGAAGAAGAACTGGGGAGGTCAGGAGGACAGGGAGCCAGCAGGAAGGTGGAAGGAG       GGCAGGCCAAGGGTGGAGGAGTCGGGGAGCAAGAAGGAGGGCAAGCGACAGGGCCCGAAGGAACCCCC       AAGGAAAAGTGGTAGCTTCCACTCCTCTGGAGAAAAGCAGAAGCAACCTCGGTGGAGGGAAGGGACTA       AGGGCAGCCATGACCCCCTGCCATCCTGGGCAGAGCTGTTGAGGCCCAAGTACCGGGCACCCCAGGGC       TGCTCAGGTGTGGACGAGTGTGCCCGGCAGGAGGGCCTGACTTTCTTTGGCACAGAGCTAGCCCCAGT       GCGGCAACAGGAGCTGGCCTCTCTGCTAAGAACATACTTGGCACGGCTGCCCTGGGCTGGGCAGCTGA       CCAAGGAGCTACCCCTCTCACCTGCTTTCTTTGGTGAGGATGGCATCTTCCGTCATGACCGCCTCCGC       TTCCGGGATTTTGTGGATGCCCTGGAGGACAGCTTGGAGGAGGTTCTAGAATTCAGCGGCCGCT                                         NOV16d, CG52171-03   SEQ ID NO: 440   676 aa   MW at 74306.8kD           Protein Sequence                     MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEGTLFQTESP           QSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKA       AWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALG       LLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLL       DKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQG       LEADCVRGPDGVCLSGGRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSV       QQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKE       KWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRK       SGSFHSSGEKQKQPRWREGTKGSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTELAPVRQ       QELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVLEFSGR                                     NOV16e, CG52171-05   SEQ ID NO: 441   1539 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GAGTCTGAGACTGGGCCCATGGAGGAAGTGGAGCGGCAGGTCCTCCCAGACCCCGAGGTGCTGGAAGC           TGTGGGGGACAGGCAGGATGGGCTAAGGGAACAGCTGCAGGCCCCAGTGCCTCCTGACAGTGTCCCCA       GCCTGCAAAACATGGGTCTTCTGCTGGACAAGCTGGCCAAGGAGAACCAGGACATCCGGCTGCTGCAG       GCCCAGCTGCAGGCCCAAAAGGAAGAGCTTCAGAGCCTGATGCACCAGCCCAAAGGGCTAGAGGAGGA       GAATGCCCAGCTCCGGGGGGCTCTGCAGCAGGGCGAAGCCTTCCAGCGGGCTCTGGAGTCAGAGCTGC       AGCAGCTGCGGGCCCGGCTCCAGGGGCTGGAGGCCGACTGTGTCCGGGGCCCAGATGGGGTGTGCCTC       AGTGGGGATAGAGGCCCACAGGGTGACAAGGCCATCAGGGAGCAAGGCCCCAGGGAGCAGGAGCCAGA       ACTCAGCTTCCTGAAGCAGAAGGAACAGCTGGAGGCTGAGGCACAGGCATTAAGGCAAGAGTTAGAGA       GGCAGCGACGGCTGCTGGGGTCTGTACAGCAGGATCTGGAGAGGAGCTTGCAGGATGCCAGCCGCGGG       GACCCAGCTCATGCTGGCTTGGCTGAGCTGGGCCACAGATTGGCCCAGAAACTGCAGGGCCTGGAGAA       CTGGGGCCAGGACCCTGGGGTCTCTGCCAATGCCTCAAAGGCCTGGCACCAGAAGTCCCACTTCCAGA       ATTCTAGGGAGTGGAGTGGAAAGGAAAAGTGGTGGGATGGGCAGAGAGACCGGAAGGCTGAGCACTGG       AAACATAAGAAGGAAGAATCTGGCCGGGAAAGGAAGAAGAACTGGGGAGGTCAGGAGGACAGGGAGCC       AGCAGGAAGGTGGAAGGAGGGCAGGCCAAGGGTGGAGGAGTCGGGGAGCAAGAAGGAGGGCAAGCGAC       AGGGCCCGAAGGAACCCCCAAGGAAAAGTGGTAGCTTCCACTCCTCTGGAGAAAAGCAGAAGCAACCT       CGGTGGAGGGAAGGGACTAAGGACAGCCATGACCCCCTGCCATCCTGGGCAGAGCTGTTGAGGCCCAA       GTACCGGGCACCCCAGGGCTGCTCAGGTGTGGACGAGTGTGCCCGGCAGGAGGGCCTGACTTTCTTTG       GCACAGAGCTAGCCCCAGTGCGGCAACAGGAGCTGGCCTCTCTGCTAAGAACATACTTGGCACGGCTG       CCCTGGGCTGGGCAGCTGACCAAGGAGCTACCCCTCTCACCTGCTTTCTTTGGTGAGGATGGCATCTT       CCGTCATGACCGCCTCCGCTTCCGGGATTTTGTGGATGCCCTGGAGGACAGCTTGGAGGAGGTGGCTG       TGCAACAGACAGGTGATGATGATGAAGTAGATGACTTTGAGGACTTCATCTTCAGCCACTTCTTTGGA       GACAAAGCACTGAAGAAGAGGTCAGGGAAGAAGGACAAGCACTCACAGAGCCCAAGAGCTGCGGGGCC       CAGGGAGGGGCACAGCCATAGCCACCACCACCACCACCGGGGC                                         NOV16e, CG52171-05   SEQ ID NO: 442   513 aa   MW at 58278.1kD           Protein Sequence                     ESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLAKENQDIRLLQ           AQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQGLEADCVRGPDGVCL       SGDRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSVQQDLERSLQDASRG       DPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKEKWWDGQRDRKAEHW       KHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRKSGSFHSSGEKQKQP       RWREGTKDSHDPLPSWAELLRPKYPAPQGCSGVDECARQEGLTFFGTELAPVRQQELASLLRTYLARL       PWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDEVDDFEDFIFSHFFG       DKALKKRSGKKDKHSQSPPAAGPREGHSHSHHHHHRG                                     NOV16f, CG52171-06   SEQ ID NO: 443   2366 bp           DNA Sequence   ORF Start: ATG at 76   ORF Stop: TGA at 2266                       GAGAAGTTAAGCTGAAGACCGAAGCAAGAGCTGGTTCAGGTGGCAGCCACAGCAGCCTCAGGGACCTC               AGCAACT   ATG GCCTCCTGCCCAGACTCTGATAATAGCTGGGTGCTTGCTGGCTCCGAGAGCCTGCCAG       TGGAGACACTGGGCCCGGCATCCAGGATGGACCCAGAATCTGAGAGAGCCCTGCAGGCCCCTCACAGC       CCCTCCAAGACAGATGGGAAAGAATTAGCTGGGACCATGGATGGAGAAGGGACGCTCTTCCAGACTGA       AAGCCCTCAGTCTGGCAGCATTCTAACAGAGGAGACTGAGGTCAAGGGCACCCTGGAAGGTGATGTTT       GTGGTGTGGAGCCTCCTGGCCCAGGAGACACAGTAGTCCAGGGAGACCTGCAGGAGACCACCGTGGTG       ACAGGCCTGGGACCAGACACACAGGACCTGGAAGGCCAGAGCCCTCCACAGAGCCTGCCTTCAACCCC       CAAAGCAGCTTGGATCAGGGAGGAGGGCCGCTGCTCCAGCAGTGACGATGACACCGACGTGGACATGG       AGGGTCTGCGGAGACGGCGGGGCCGGGAGGCCGGCCCACCTCAGCCCATGGTGCCCCTGGCTGTGGAG       AACCAGGCTGGGGGTGAGGGTGCAGGCGGGGAGCTGGGCATCTCCCTCAACATGTGCCTCCTTGGGGC       CCTGGTTCTGCTTGGCCTGGGGGTCCTCCTCTTCTCAGGTGGCCTCTCAGAGTCTGAGACTGGGCCCA       TGGAGGAAGTGGAGCGGCAGGTCCTCCCAGACCCCGAGGTGCTGGAAGCTGTGGGGGACAGGCAGGAT       GGGCTAAGGGAACAGCTGCAGGCCCCAGTGCCTCCTGACAGTGTCCCCAGCCTGCAAAACATGGGTCT       TCTGCTGGACAAGCTGGCCAAGGAGAACCAGGACATCCGGCTGCTGCAGGCCCAGCTGCAGGCCCAAA       AGGAAGAGCTTCAGAGCCTGATGCACCAGCCCAAAGGGCTAGAGGAGGAGAATGCCCAGCTCCGGGGG       GCTCTGCAGCAGGGCGAAGCCTTCCAGCGGGCTCTGGAGTCAGAGCTGCAGCAGCTGCGGGCCCGGCT       CCAGGGGCTGGAGGCCGACTGTGTCCGGGGCCCAGATGGGGTGTGCCTCAGTGGGGATAGAGGCCCAC       AGGGTGACAAGGCCATCAGGGAGCAAGGCCCCAGGGAGCAGGAGCCAGAACTCAGCTTCCTGAATCAG       AAGGAACAGCTGGAGGCTGAGGCACAGGCATTAAGGCAAGAGTTAGAGAGGCAGCGACGGCTGCTGGG       GTCTGTACAGCAGGATCTGGAGAGGAGCTTGCAGGATGCCAGCCGCGGGGACCCAGCTCATGCTGGCT       TGGCTGAGCTGGGCCACAGATTGGCCCAGAAACTGCAGGGCCTGGAGAACTGGGGCCAGGACCCTGGG       GTCTCTGCCAATGCCTCAAAGGCCTGGCACCAGAAGTCCCACTTCCAGAATTCTAGGGAGTGGAGTGG       AAAGGAAAAGTGGTGGGATGGGCAGAGAGACCGGAAGGCTGAGCACTGGAAACATAAGAAGGAAGAAT       CTGGCCGGGAAAGGAAGAAGAACTGGGGAGGTCAGGAGGACAGGGAGCCAGCAGGAAGGTGGAAGGAG       GGCAGGCCAAGGGTGGAGGAGTCGGGGAGCAAGAAGGAGGGCAAGCGACAGGCCCCGAAGGAACCCCC       AAGGAAAAGTGGTAGCTTCCACTCCTCTGGAGAAAAGCAGAAGCAACCTCGGTGGAGGGAAGGGACTA       AGGACAGCCATGACCCCCTGCCATCCTGGGCAGAGCTGTTGAGGCCCAAGTACCGGGCACCCCAGGGC       TGCTCAGGTGTGGACGAGTGTGCCCGGCAGGAGGGCCTGACTTTCTTTGGCACAGAGCTAGCCCCAGT       GCGGCAACAGGAGCTGGCCTCTCTGCTAAGAACATACTTGGCACGGCTGCCCTGGGCTGGGCAGCTGA       CCAAGGAGCTACCCCTCTCACCTGCTTTCTTTGGTGAGGATGGCATCTTCCGTCATGACCGCCTCCGC       TTCCGGGATTTTGTGGATGCCCTGGAGGACAGCTTGGAGGAGGTGGCTGTGCAACAGACAGGTGATGA       TGATGAAGTAGATGACTTTGAGGACTTCATCTTCAGCCACTTCTTTGGAGACAAAGCACTGAAGAAGA       GGTCAGGGAAGAAGGACAAGCACTCACAGAGCCCAAGAGCTGCGGGGCCCAGGGAGGGGCACAGCCAT       AGCCACCACCACCACCGGGGC TGA   CACCCTGCCCCACAGGGAATGGCCTTGGCCTGGCCCAGCCCAAG           ATCCCAGCGTTATCTAACTCCTGGAGGGTGGACTCTGTCCTGGCTTGTTTGGTG                                           NOV16f, CG52171-06   SEQ ID NO: 444   730 aa   MW at 80563.4kD           Protein Sequence                     MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEGTLFQTESP           QSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKA       AWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALV       LLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLL       DKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQG       LEADCVRGPDGVCLSGDRGPQGDKAIREQGPREQEPELSFLNQKEQLEAEAQALRQELERQRRLLGSV       QQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKE       KWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQAPKEPPRK       SGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTELAPVRQ       QELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDE       VDDFEDFIFSHFFGDKALKKRSGKKDKHSQSPRAAGPREGHSHSHHHHRG                                     NOV16g, 5NP13374628   SEQ ID NO: 445   2403 bp           of CG52171-04,   ORF Start: ATG at 81   ORF Stop: TGA at 2292       DNA Sequence   SNP Pos: 373   SNP Change: A to G                       GGCACGAGAAGTTAAGCTGAAGACCGAAGCAAGAGCTGGTTCAGGTGGCAGCCACAGCAGCCTCAGGG               ACCTCAGCAACT   ATG GCCTCCTGCCCAGACTCTGATAATAGCTGGGTGCTTGCTGGCTCCGAGAGCCT       GCCAGTGGAGACACTGGGCCCGGCATCCAGGATGGACCCAGAATCTGAGAGAGCCCTGCAGGCCCCTC       ACAGCCCCTCCAAGACAGATGGGAAAGAATTAGCTGGGACCATGGATGGAGAAGGGACGCTCTTCCAG       ACTGAAAGCCCTCAGTCTGGCAGCATTCTAACAGAGGAGACTGAGGTCAAGGGCACCCTGGAAGGTGA       TGTTTGTGGTGTGGAGCCTCCTGGCCCAGGAG   G   CACAGTAGTCCAGGGAGACCTGCAGGAGACCACCG       TGGTGACAGGCCTGGGACCAGACACACAGGACCTGGAAGGCCAGAGCCCTCCACAGAGCCTGCCTTCA       ACCCCCAAAGCAGCTTGGATCAGGGAGGAGGGCCGCTGCTCCAGCAGTGACGATGACACCGACGTGGA       CATGGAGGGTCTGCGGAGACGGCGGGGCCGGGAGGCCGGCCCACCTCAGCCCATGGTGCCCCTGGCTG       TGGAGAACCAGGCTGGGGGTGAGGGTGCAGGCGGGGAGCTGGGCATCTCCCTCAACATGTGCCTCCTT       GGGGCCCTGGTTCTGCTTGGCCTGGGGGTCCTCCTCTTCTCAGGTGGCCTCTCAGAGTCTGAGACTGG       GCCCATGGAGGAAGTGGAGCGGCAGGTCCTCCCAGACCCCGAGGTGCTGGAAGCTGTGGGGGACAGGC       AGGATGGGCTAAGGGAACAGCTGCAGGCCCCAGTGCCTCCTGACAGTGTCCCCAGCCTGCAAAACATG       GGTCTTCTGCTGGACAAGCTGGCCAAGGAGAACCAGGACATCCGGCTGCTGCAGGCCCAGCTGCAGGC       CCAAAAGGAAGAGCTTCAGAGCCTGATGCACCAGCCCAAAGGGCTAGAGGAGGAGAATGCCCAGCTCC       GGGGGGCTCTGCAGCAGGGCGAAGCCTTCCAGCGGGCTCTGGAGTCAGAGCTGCAGCAGCTGCGGGCC       CGGCTCCAGGGGCTGGAGGCCGACTGTGTCCGGGGCCCAGATGGGGTGTGCCTCAGTGGGGATAGAGG       CCCACAGGGTGACAAGGCCATCAGGGAGCAAGGCCCCAGGGAGCAGGAGCCAGAACTCAGCTTCCTGA       AGCAGAAGGAACAGCTGGAGGCTGAGGCACAGGCATTAAGGCAAGAGTTAGAGAGGCAGCGACGGCTG       CTGGGGTCTGTACAGCAGGATCTGGAGAGGAGCTTGCAGGATGCCAGCCGCGGGGACCCAGCTCATGC       TGGCTTGGCTGAGCTGGGCCACAGATTGGCCCAGAAACTGCAGGGCCTGGAGAACTGGGGCCAGGACC       CTGGGGTCTCTGCCAATGCCTCAAAGGCCTGGCACCAGAAGTCCCACTTCCAGAATTCTAGGGAGTGG       AGTGGAAAGGAAAAGTGGTGGGATGGGCAGAGAGACCGGAAGGCTGAGCACTGGAAACATAAGAAGGA       AGAATCTGGCCGGGAAAGGAAGAAGAACTGGGGAGGTCAGGAGGACAGGGAGCCAGCAGGAAGGTGGA       AGGAGGGCAGGCCAAGGGTGGAGGAGTCGGGGAGCAAGAAGGAGGGCAAGCGACAGGGCCCGAAGGAA       CCCCCAAGGAAAAGTGGTAGCTTCCACTCCTCTGGAGAAAAGCAGAAGCAACCTCGGTGGAGGGAAGG       GACTAAGGACAGCCATGACCCCCTGCCATCCTGGGCAGAGCTGTTGAGGCCCAAGTACCGGGCACCCC       AGGGCTGCTCAGGTGTGGACGAGTGTGCCCGGCAGGAGGGCTTGACTTTCTTTGGCACAGAGCTAGCC       CCAGTGCGGCAACAGGAGCTGGCCTCTCTGCTAAGAACATACTTGGCACGGCTGCCCTGGGCTGGGCA       GCTGACCAAGGAGCTACCCCTCTCACCTGCTTTCTTTGGTGAGGATGGCATCTTCCGTCATGACCGCC       TCCGCTTCCGGGATTTTGTGGATGCCCTGGAGGACAGCTTGGAGGAGGTGGCTGTGCAACAGACAGGT       GATGATGATGAAGTAGATGACTTTGAGGACTTCATCTTCAGCCACTTCTTTGGAGACAAAGCACTGAA       GAAGAGGCCTCTTCCTCCCCACAGGTCAGGGAAGAAGGACAAGCACTCACAGAGCCCAAGAGCTGCGG       GGCCCAGGGAGGGGCACAGCCATAGCCACCACCACCACCACCGGGGC TGA   CACCCTGCCCCACAGGGA           ATGGCCTTGGCCTGGCCCAGCCCAAGATCCCAGCGTTATCCAACTCCTGGAGGGTGGACTCTGTCCTG           GCTTGTTTGGTGTCCTCAGATAT                                           NOV16g, SNP13374628   SEQ ID NO: 446   737 aa   MW at 81340.4kD           of CG52171-04,   SNP Pos: 98       SNP Change:       Protein Sequence           Asp to Gly                     MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEGTLFQTESP           QSGSILTEETEVKGTLEGDVCGVEPPGPGGTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKA       AWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALV       LLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLL       DKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALEsELQQLRARLQG       LEADCVRGPDGVCLSGDRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRPLLGSV       QQDLERSLQDASRGDPAHAGLAELGHPLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKE       KWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRK       SGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTELAPVRQ       QELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDE       VDDFEDFIFSHFFGDKALKKRPLPPHRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG                                     NOV16h, SNP13377329   SEQ ID NO: 447   2403 bp           of CG52171-04,   ORF Start: ATG at 81   ORF Stop: TGA at 2292       DNA Sequence   SNP Pos: 1150   SNP Change: A to G                       GGCACGAGAAGTTAAGCTGAAGACCGAAGCAAGAGCTGGTTCAGGTGOCAGCCACAGCAGCCTCAGGG               ACCTCAGCAACT   ATG GCCTCCTGCCCAGACTCTGATAATAGCTGGGTGCTTGCTGGCTCCGAGAGCCT       GCCAGTGGAGACACTGGGCCCGGCATCCAGGATGGACCCAGAATCTGAGAGAGCCCTGCAGGCCCCTC       ACAGCCCCTCCAAGACAGATGGGAAAGAATTAGCTGGGACCATGGATGGAGAAGGGACGCTCTTCCAG       ACTGAAAGCCCTCAGTCTGGCAGCATTCTAACAGAGGAGACTGAGGTCAAGGGCACCCTGGAAGGTGA       TGTTTGTGGTGTGGAGCCTCCTGGCCCAGGAGACACAGTAGTCCAGGGAGACCTGCAGGAGACCACCG       TGGTGACAGGCCTGGGACCAGACACACAGGACCTGGAAGGCCAGAGCCCTCCACAGAGCCTGCCTTCA       ACCCCCAAAGCAGCTTGGATCAGGGAGGAGGGCCGCTGCTCCAGCAGTGACGATGACACCGACGTGGA       CATGGAGGGTCTGCGGAGACGGCGGGGCCGGGAGGCCGGCCCACCTCAGCCCATGGTGCCCCTGGCTG       TGGAGAACCAGGCTGGGGGTGAGGGTGCAGGCGGGGAGCTGGGCATCTCCCTCAACATGTGCCTCCTT       GGGGCCCTGGTTCTGCTTGGCCTGGGGGTCCTCCTCTTCTCAGGTGGCCTCTCAGAGTCTGAGACTGG       GCCCATGGAGGAAGTGGAGCGGCAGGTCCTCCCAGACCCCGAGGTGCTGGAAGCTGTGGGGGACAGGC       AGGATGGGCTAAGGGAACAGCTGCAGGCCCCAGTGCCTCCTGACAGTGTCCCCAGCCTGCAAAACATG       GGTCTTCTGCTGGACAAGCTGGCCAAGGAGAACCAGGACATCCGGCTGCTGCAGGCCCAGCTGCAGGC       CCAAAAGGAAGAGCTTCAGAGCCTGATGCACCAGCCCAAAGGGCTAGAGGAGGAGAATGCCCAGCTCC       GGGGGGCTCTGCAGCAGGGCGAAGCCTTCCAGCGGGCTCTGGAGTCAGAGCTGCAGCAGCTGCGGGCC       CGGCTCCAGGGGCTGGAGGCCGACTGTGTCCGGGGCCCAGATGGGGTGTGCCTCAGTGGGGGTAGAGG       CCCACAGGGTGACAAGGCCATCAGGGAGCAAGGCCCCAGGGAGCAGGAGCCAGAACTCAGCTTCCTGA       AGCAGAAGGAACAGCTGGAGGCTGAGGCACAGGCATTAAGGCAAGAGTTAGAGAGGCAGCGACGGCTG       CTGGGGTCTGTACAGCAGGATCTGGAGAGGAGCTTGCAGGATGCCAGCCGCGGGGACCCAGCTCATGC       TGGCTTGGCTGAGCTGGGCCACAGATTGGCCCAGAAACTGCAGGGCCTGGAGAACTGGGGCCAGGACC       CTGGGGTCTCTGCCAATGCCTCAAAGGCCTGGCACCAGAAGTCCCACTTCCAGAATTCTAGGGAGTGG       AGTGGAAAGGAAAAGTGGTGGGATGGGCAGAGAGACCGGAAGGCTGAGCACTGGAAACATAAGAAGGA       AGAATCTGGCCGGGAAAGGAAGAAGAACTGGGGAGGTCAGGAGGACAGGGAGCCAGCAGGAAGGTGGA       AGGAGGGCAGGCCAAGGGTGGAGGAGTCGGGGAGCAAGAAGGAGGGCAAGCGACAGGGCCCGAAGGAA       CCCCCAAGGAAAAGTGGTAGCTTCCACTCCTCTGGAGAAAAGCAGAAGCAACCTCGGTGGAGGGAAGG       GACTAAGGACAGCCATGACCCCCTGCCATCCTGGGCAGAGCTGTTGAGGCCCAAGTACCGGGCACCCC       AGGGCTGCTCAGGTGTGGACGAGTGTGCCCGGCAGGAGGGCTTGACTTTCTTTGGCACAGAGCTAGCC       CCAGTGCGGCAACAGGAGCTGGCCTCTCTGCTAAGAACATACTTGGCACGGCTGCCCTGGGCTGGGCA       GCTGACCAAGGAGCTACCCCTCTCACCTGCTTTCTTTGGTGAGGATGGCATCTTCCGTCATGACCGCC       TCCGCTTCCGGGATTTTGTGGATGCCCTGGAGGACAGCTTGGAGGAGGTGGCTGTGCAACAGACAGGT       GATGATGATGAAGTAGATGACTTTGAGGACTTCATCTTCAGCCACTTCTTTGGAGACAAAGCACTGAA       GAAGAGGCCTCTTCCTCCCCACAGGTCAGGGAAGAAGGACAAGCACTCACAGAGCCCAAGAGCTGCGG       GGCCCAGGGAGGGGCACAGCCATAGCCACCACCACCACCACCGGGGC TGA   CACCCTGCCCCACAGGGA           ATGGCCTTGGCCTGGCCCAGCCCAAGATCCCAGCGTTATCCAACTCCTGGAGGGTGGACTCTGTCCTG           GCTTGTTTGGTGTCCTCAGATAT                                           NOV16h, SNP13377329   SEQ ID NO: 448   737 aa   MW at 81340.4kD           of CG52171-04,   SNP Pos: 357       SNP Change:       Protein Sequence           Asp to Gly                     MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEGTLFQTESP           QSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKA       AWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALV       LLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLL       DKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQG       LEADCVRGPDGVCLSGGRGPQGDKAIRBQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSV       QQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKE       KWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRK       SGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTELAPVRQ       QELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDE       VDDFEDFIFSHFFGDKALKKRPLPPHRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG                                     NOV16i, SNP13374627   SEQ ID NO: 449   2403 bp           of CG52171-04,   ORF Start: ATG at 81   ORF Stop: TGA at 2292       DNA Sequence   SNP Pos: 1903   SNP Change: C to T                       GGCACGAGAAGTTAAGCTGAAGACCGAAGCAAGAGCTGGTTCAGGTGGCAGCCACAGCAGCCTCAGGG               ACCTCAGCAACT   ATG GCCTCCTGCCCAGACTCTGATAATAGCTGGGTGCTTQCTGGCTCCGAGAGCCT       GCCAGTGGAGACACTGGGCCCGGCATCCAGGATGGACCCAGAATCTGAGAGAGCCCTGCAGGCCCCTC       ACAGCCCCTCCAAGACAGATGGGAAAGAATTAGCTGGGACCATGGATGGAGAAGGGACGCTCTTCCAG       ACTGAAAGCCCTCAGTCTGGCAGCATTCTAACAGAGGAGACTGAGGTCAAGGGCACCCTGGAAGGTGA       TGTTTGTGGTGTGGAGCCTCCTGGCCCAGGAGACACAGTAGTCCAGGGAGACCTGCAGGAGACCACCG       TGGTGACAGGCCTGGGACCAGACACACAGGACCTGGAAGGCCAGAGCCCTCCACAGAGCCTGCCTTCA       ACCCCCAAAGCAGCTTGGATCAGGGAGGAGGGCCGCTGCTCCAGCAGTGACGATGACACCGACGTGGA       CATGGAGGGTCTGCGGAGACGGCGGGGCCGGGAGGCCGGCCCACCTCAGCCCATGGTGCCCCTGGCTG       TGGAGAACCAGGCTGGGGGTGAGGGTGCAGGCGGGGAGCTGGGCATCTCCCTCAACATGTGCCTCCTT       GGGGCCCTGGTTCTGCTTGGCCTGGGGGTCCTCCTCTTCTCAGGTGGCCTCTCAGAGTCTGAGACTGG       GCCCATGGAGGAAGTGGAGCGGCAGGTCCTCCCAGACCCCGAGGTGCTGGAAGCTGTGGGGGACAGGC       AGGATGGGCTAAGGGAACAGCTGCAGGCCCCAGTGCCTCCTGACAGTGTCCCCAGCCTGCAAAACATG       GGTCTTCTGCTGGACAAGCTGGCCAAGGAGAACCAGGACATCCGGCTGCTGCAGGCCCAGCTGCAGGC       CCAAAAGGAAGAGCTTCAGAGCCTGATGCACCAGCCCAAAGGGCTAGAGGAGGAGAATGCCCAGCTCC       GGGGGGCTCTGCAGCAGGGCGAAGCCTTCCAGCGGGCTCTGGAGTCAGAGCTGCAGCAGCTGCGGGCC       CGGCTCCAGGGGCTGGAGGCCGACTGTGTCCGGGGCCCAGATGGGGTGTGCCTCAGTGGGGATAGAGG       CCCACAGGGTGACAAGGCCATCAGGGAGCAAGGCCCCAGGGAGCAGGAGCCAGAACTCAGCTTCCTGA       AGCAGAAGGAACAGCTGGAGGCTGAGGCACAGGCATTAAGGCAAGAGTTAGAGAGGCAGCGACGGCTG       CTGGGGTCTGTACAGCAGGATCTGGAGAGGAGCTTGCAGGATGCCAGCCGCGGGGACCCAGCTCATGC       TGGCTTGGCTGAGCTGGGCCACAGATTGGCCCAGAAACTGCAGGGCCTGGAGAACTGGGGCCAGGACC       CTGGGGTCTCTGCCAATGCCTCAAAGGCCTGGCACCAGAAGTCCCACTTCCAGAATTCTAGGGAGTGG       AGTGGAAAGGAAAAGTGGTGGGATGGGCAGAGAGACCGGAAGGCTGAGCACTGGAAACATAAGAAGGA       AGAATCTGGCCGGGAAAGGAAGAAGAACTGGGGAGGTCAGGAGGACAGGGAGCCAGCAGGAAGGTGGA       AGGAGGGCAGGCCAAGGGTGGAGGAGTCGGGGAGCAAGAAGGAGGGCAAGCGACAGGGCCCGAAGGAA       CCCCCAAGGAAAAGTGGTAGCTTCCACTCCTCTGGAGAAAAGCAGAAGCAACCTCGGTGGAGGGAAGG       GACTAAGGACAGCCATGACCCCCTGCCATCCTGGGCAGAGCTGTTGAGGCCCAAGTACCGGGCACCCC       AGGGCTGCTCAGGTGTGGACGAGTGTGCCCGGCAGGAGGGCTTGACTTTCTTTGGCACAGAGCTAGTC       CCAGTGCGGCAACAGGAGCTGGCCTCTCTGCTAAGAACATACTTGGCACGGCTGCCCTGGGCTGGGCA       GCTGACCAAGGAGCTACCCCTCTCACCTGCTTTCTTTGGTGAGGATGGCATCTTCCGTCATGACCGCC       TCCGCTTCCGGGATTTTGTGGATGCCCTGGAGGACAGCTTGGAGGAGGTGGCTGTGCAACAGACAGGT       GATGATGATGAAGTAGATGACTTTGAGGACTTCATCTTCAGCCACTTCTTTGGAGACAAAGCACTGAA       GAAGAGGCCTCTTCCTCCCCACAGGTCAGGGAAGAAGGACAAGCACTCACAGAGCCCAAGAGCTGCGG       GGCCCAGGGAGGGGCACAGCCATAGCCACCACCACCACCACCGGGGC TGA   CACCCTGCCCCACAGGGA           ATGGCCTTGGCCTGGCCCAGCCCAAGATCCCAGCGTTATCCAACTCCTGGAGGGTGGACTCTGTCCTG           GCTTGTTTGGTGTCCTCAGATAT                                           NOV16i, SNP13374627   SEQ ID NO: 450   737 aa   MW at 81426.5kD           of CG52171-04,   SNP Pos: 608       SNP Change:       Protein Sequence           Ala to Val                     MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEGTLFQTESP           QSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKA       AWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALV       LLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLL       DKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQG       LEADCVRGPDGVCLSGDRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSV       QQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKE       KWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRK       SGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTELVPVRQ       QELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDE       VDDFEDFIFSHFFGDKALKKRPLPPHRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG                                     NOV16j, SNP13374626   SEQ ID NO: 451   2403 bp           of CG52171-04,   ORF Start: ATG at 81   ORF Stop: TGA at 2292       DNA Sequence   SNP Pos: 1918   SNP Change:A to G                       GGCACGAGAAGTTAAGCTGAAGACCGAAGCAAGAGCTGGTTCAGGTGGCAGCCACAGCAGCCTCAGGG               ACCTCAGCAACT   ATG GCCTCCTGCCCAGACTCTGATAATAGCTGGGTGCTTGCTGGCTCCGAGAGCCT       GCCAGTGGAGACACTGGGCCCGGCATCCAGGATGGACCCAGAATCTGAGAGAGCCCTGCAGGCCCCTC       ACAGCCCCTCCAAGACAGATGGGAAAGAATTAGCTGGGACCATGGATGGAGAAGGGACGCTCTTCCAG       ACTGAAAGCCCTCAGTCTGGCAGCATTCTAACAGAGGAGACTGAGGTCAAGGGCACCCTGGAAGGTGA       TGTTTGTGGTGTGGAGCCTCCTGGCCCAGGAGACACAGTAGTCCAGGGAGACCTGCAGGAGACCACCG       TGGTGACAGGCCTGGGACCAGACACACAGGACCTGGAAGGCCAGAGCCCTCCACAGAGCCTGCCTTCA       ACCCCCAAAGCAGCTTGGATCAGGGAGGAGGGCCGCTGCTCCAGCAGTGACGATGACACCGACGTGGA       CATGGAGGGTCTGCGGAGACGGCGGGGCCGGGAGGCCGGCCCACCTCAGCCCATGGTGCCCCTGGCTG       TGGAGAACCAGGCTGGGGGTGAGGGTGCAGGCGGGGAGCTGGGCATCTCCCTCAACATGTGCCTCCTT       GGGGCCCTGGTTCTGCTTGGCCTGGGGGTCCTCCTCTTCTCAGGTGGCCTCTCAGAGTCTGAGACTGG       GCCCATGGAGGAAGTGGAGCGGCAGGTCCTCCCAGACCCCGAGGTGCTGGAAGCTGTGGGGGACAGGC       AGGATGGGCTAAGGGAACAGCTGCAGGCCCCAGTGCCTCCTGACAGTGTCCCCAGCCTGCAAAACATG       GGTCTTCTGCTGGACAAGCTGGCCAAGGAGAACCAGGACATCCGGCTGCTGCAGGCCCAGCTGCAGGC       CCAAAAGGAAGAGCTTCAGAGCCTGATGCACCAGCCCAAAGGGCTAGAGGAGGAGAATGCCCAGCTCC       GGGGGGCTCTGCAGCAGGGCGAAGCCTTCCAGCGGGCTCTGGAGTCAGAGCTGCAGCAGCTGCGGGCC       CGGCTCCAGGGGCTGGAGGCCGACTGTGTCCGGGGCCCAGATGGGGTGTGCCTCAGTGGGGATAGAGG       CCCACAGGGTGACAAGGCCATCAGGGAGCAAGGCCCCAGGGAGCAGGAGCCAGAACTCAGCTTCCTGA       AGCAGAAGGAACAGCTGGAGGCTGAGGCACAGGCATTAAGGCAAGAGTTAGAGAGGCAGCGACGGCTG       CTGGGGTCTGTACAGCAGGATCTGGAGAGGAGCTTGCAGGATGCCAGCCGCGGGGACCCAGCTCATGC       TGGCTTGGCTGAGCTGGGCCACAGATTGGCCCAGAAACTGCAGGGCCTGGAGAACTGGGGCCAGGACC       CTGGGGTCTCTGCCAATGCCTCAAAGGCCTGGCACCAGAAGTCCCACTTCCAGAATTCTAGGGAGTGG       AGTGGAAAGGAAAAGTGGTGGGATGGGCAGAGAGACCGGAAGGCTGAGCACTGGAAACATAAGAAGGA       AGAATCTGGCCGGGAAAGGAAGAAGAACTGGGGAGGTCAGGAGGACAGGGAGCCAGCAGGAAGGTGGA       AGGAGGGCAGGCCAAGGGTGGAGGAGTCGGGGAGCAAGAAGGAGGGCAAGCGACAGGGCCCGAAGGAA       CCCCCAAGGAAAAGTGGTAGCTTCCACTCCTCTGGAGAAAAGCAGAAGCAACCTCGGTGGAGGGAAGG       GACTAAGGACAGCCATGACCCCCTGCCATCCTGGGCAGAGCTGTTGAGGCCCAAGTACCGGGCACCCC       AGGGCTGCTCAGGTGTGGACGAGTGTGCCCGGCAGGAGGGCTTGACTTTCTTTGGCACAGAGCTAGCC       CCAGTGCGGCAAC   G   GGAGCTGGCCTCTCTGCTAAGAACATACTTGGCACGGCTGCCCTGGGCTGGGCA       GCTGACCAAGGAGCTACCCCTCTCACCTGCTTTCTTTGGTGAGGATGGCATCTTCCGTCATGACCGCC       TCCGCTTCCGGGATTTTGTGGATGCCCTGGAGGACAGCTTGGAGGAGGTGGCTGTGCAACAGACAGGT       GATGATGATGAAGTAGATGACTTTGAGGACTTCATCTTCAGCCACTTCTTTGGAGACAAAGCACTGAA       GAAGAGGCCTCTTCCTCCCCACAGGTCAGGGAAGAAGGACAAGCACTCACAGAGCCCAAGAGCTGCGG       GGCCCAGGGAGGGGCACAGCCATAGCCACCACCACCACCACCGGGGC TGA C ACCCTGCCCCACAGGGA           ATGGCCTTGGCCTGGCCCAGCCCAAGATCCCAGCGTTATCCAACTCCTGGAGGGTGGACTCTGTCCTG           GCTTGTTTGGTGTCCTCAGATAT                                           NOV16j, SNP13374626   SEQ ID NO: 452   737 aa   MW at 81426.5kD           of CG52171-04,   SNP Pos: 613       SNP Change:       Protein Sequence           Gln to Arg                     MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEGTLFQTESP           QSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKA       AWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALV       LLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLL       DKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQG       LEADCVRGPDGVCLSGDRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSV       QQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKE       KWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRK       SGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYHAPQGCSGVDECARQEGLTFFGTELAPVRQ           R   ELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDE       VDDFEDFIFSHFFGDKALKKRPLPPHRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG                                     NOV16k, SNP13374625   SEQ ID NO: 453   2403 bp           of CG52171-04,   ORF Start: ATG at 81   ORF Stop: TGA at 2292       DNA Sequence   SNP Pos: 1951   SNP Change: C to T                       GGCACGAGAAGTTAAGCTGAAGACCGAAGCAAGAGCTGGTTCAGGTGGCAGCCACAGCAGCCTCAGGG               ACCTCAGCAACT   ATG GCCTCCTGCCCAGACTCTQATAATAGCTGGGTGCTTGCTGGCTCCGAGAGCCT       GCCAGTGGAGACACTGGGCCCGGCATCCAGGATGGACCCAGAATCTGAGAGAGCCCTGCAGGCCCCTC       ACAGCCCCTCCAAGACAGATGGGAAAGAATTAGCTGGGACCATGGATGGAGAAGGGACGCTCTTCCAG       ACTGAAAGCCCTCAGTCTGGCAGCATTCTAACAGAGGAGACTGAGGTCAAGGGCACCCTGGAAGGTGA       TGTTTGTGGTGTGGAGCCTCCTGGCCCAGGAGACACAGTAGTCCAGGGAGACCTGCAGGAGACCACCG       TGGTGACAGGCCTGGGACCAGACACACAGGACCTGGAAGGCCAGAGCCCTCCACAGAGCCTGCCTTCA       ACCCCCAAAGCAGCTTGGATCAGGGAGGAGGGCCGCTGCTCCAGCAGTGACGATGACACCGACGTGGA       CATGGAGGGTCTGCGGAGACGGCGGGGCCGGGAGGCCGGCCCACCTCAGCCCATGGTGCCCCTGGCTG       TGGAGAACCAGGCTGGGGGTGAGGGTGCAGGCGGGGAGCTGGGCATCTCCCTCAACATGTGCCTCCTT       GGGGCCCTGGTTCTGCTTGGCCTGGGGGTCCTCCTCTTCTCAGGTGGCCTCTCAGAGTCTGAGACTGG       GCCCATGGAGGAAGTGGAGCGGCAGGTCCTCCCAGACCCCGAGGTGCTGGAAGCTGTGGGGGACAGGC       AGGATGGGCTAAGGGAACAGCTGCAGGCCCCAGTGCCTCCTGACAGTGTCCCCAGCCTGCAAAACATG       GGTCTTCTGCTGGACAAGCTGGCCAAGGAGAACCAGGACATCCGGCTGCTGCAGGCCCAGCTGCAGGC       CCAAAAGGAAGAGCTTCAGAGCCTGATGCACCAGCCCAAAGGGCTAGAGGAGGAGAATGCCCAGCTCC       GGGGGGCTCTGCAGCAGGGCGAAGCCTTCCAGCGGGCTCTGGAGTCAGAGCTGCAGCAGCTGCGGGCC       CGGCTCCAGGGGCTGGAGGCCGACTGTGTCCGGGGCCCAGATGGGGTGTGCCTCAGTGGGGATAGAGG       CCCACAGGGTGACAAGGCCATCAGGGAGCAAGGCCCCAGGGAGCAGGAGCCAGAACTCAGCTTCCTGA       AGCAGAAGGAACAGCTGGAGGCTGAGGCACAGGCATTAAGGCAAGAGTTAGAGAGGCAGCGACGGCTG       CTGGGGTCTGTACAGCAGGATCTGGAGAGGAGCTTGCAGGATGCCAGCCGCGGGGACCCAGCTCATGC       TGGCTTGGCTGAGCTGGGCCACAGATTGGCCCAGAAACTGCAGGGCCTGGAGAACTGGGGCCAGGACC       CTGGGGTCTCTGCCAATGCCTCAAAGGCCTGGCACCAGAAGTCCCACTTCCAGAATTCTAGGGAGTGG       AGTGGAAAGGAAAAGTGGTGGGATGGGCAGAGAGACCGGAAGGCTGAGCACTGGAAACATAAGAAGGA       AGAATCTGGCCGGGAAAGGAAGAAGAACTGGGGAGGTCAGGAGGACAGGGAGCCAGCAGGAAGGTGGA       AGGAGGGCAGGCCAAGGGTGGAGGAGTCGGGGAGCAAGAAGGAGGGCAAGCGACAGGGCCCGAAGGAA       CCCCCAAGGAAAAGTGGTAGCTTCCACTCCTCTGGAGAAAAGCAGAAGCAACCTCGGTGGAGGGAAGG       GACTAAGGACAGCCATGACCCCCTGCCATCCTGGGCAGAGCTGTTGAGGCCCAAGTACCGGGCACCCC       AGGGCTGCTCAGGTGTGGACGAGTGTGCCCGGCAGGAGGGCTTGACTTTCTTTGGCACAGAGCTAGCC       CCAGTGCGGCAACAGGAGCTGGCCTCTCTGCTAAGAACATACTTGG   T   ACGGCTGCCCTGGGCTGGGCA       GCTGACCAAGGAGCTACCCCTCTCACCTGCTTTCTTTGGTGAGGATGGCATCTTCCGTCATGACCGCC       TCCGCTTCCGGGATTTTGTGGATGCCCTGGAGGACAGCTTGGAGGAGGTGGCTGTGCAACAGACAGGT       GATGATGATGAAGTAGATGACTTTGAGGACTTCATCTTCAGCCACTTCTTTGGAGACAAAGCACTGAA       GAAGAGGCCTCTTCCTCCCCACAGGTCAGGGAAGAAGGACAAGCACTCACAGAGCCCAAGAGCTGCGG       GGCCCAGGGAGGGGCACAGCCATAGCCACCACCACCACCACCGGGGC TGA   CACCCTGCCCCACAGGGA           ATGGCCTTGGCCTGGCCCAGCCCAAGATCCCAGCGTTATCCAACTCCTGGAGGGTGGACTCTGTCCTG           GCTTGTTTGGTGTCCTCAGATAT                                           NOV16k, SNP13374625   SEQ ID NO: 454   737 aa   MW at 81426.5kD           of CG52171-04,   SNP Pos: 624       SNP Change:       Protein Sequence           Ala to Val                     MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEGTLFQTESP           QSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKA       AWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALV       LLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLL       DKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQG       LEADCVRGPDGVCLSGDRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSV       QQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKE       KWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRK       SGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTELAPVRQ       QELASLLRTYL   V   RLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDE       VDDFEDFIFSHFFGDKALKKRPLPPHRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG                                     NOV16l, SNP13374624   SEQ ID NO: 455   2403 bp           of CG52171-04,   ORF Start: ATG at 81   ORF Stop: TGA at 2292       DNA Sequence   SNP Pos: 2124   SNP Change: G to T                       GGCACGAGAAGTTAAGCTGAAGACCGAAGCAAGAGCTGGTTCAGGTGGCAGCCACAGCAGCCTCAGGC               ACCTCAGCAACT   ATG GCCTCCTGCCCAGACTCTGATAATAGCTGGGTGCTTGCTGGCTCCGAGAGCCT       GCCAGTGGAGACACTGGGCCCGGCATCCAGGATGGACCCAGAATCTGAGAGAGCCCTGCAGGCCCCTC       ACAGCCCCTCCAAGACAGATGGGAAAGAATTAGCTGGGACCATGGATGGAGAAGGGACGCTCTTCCAG       ACTGAAAGCCCTCAGTCTGGCAGCATTCTAACAGAGGAGACTGAGGTCAAGGGCACCCTGGAAGGTGA       TGTTTGTGGTGTGGAGCCTCCTGGCCCAGGAGACACAGTAGTCCAGGGAGACCTGCAGGAGACCACCG       TGGTGACAGGCCTGGGACCAGACACACAGGACCTGGAAGGCCAGAGCCCTCCACAGAGCCTGCCTTCA       ACCCCCAAAGCAGCTTGGATCAGGGAGGAGGGCCGCTGCTCCAGCAGTGACGATGACACCGACGTGGA       CATGGAGGGTCTGCGGAGACGGCGGGGCCGGGAGGCCGGCCCACCTCAGCCCATGGTGCCCCTGGCTG       TGGAGAACCAGGCTGGGGGTGAGGGTGCAGGCGGGGAGCTGGGCATCTCCCTCAACATGTGCCTCCTT       GGGGCCCTGGTTCTGCTTGGCCTGGGGGTCCTCCTCTTCTCAGGTGGCCTCTCAGAGTCTGAGACTGG       GCCCATGGAGGAAGTGGAGCGGCAGGTCCTCCCAGACCCCGAGGTGCTGGAAGCTGTGGGGGACAGGC       AGGATGGGCTAAGGGAACAGCTGCAGGCCCCAGTGCCTCCTGACAGTGTCCCCAGCCTGCAAAACATG       GGTCTTCTGCTGGACAAGCTGGCCAAGGAGAACCAGGACATCCGGCTGCTGCAGGCCCAGCTGCAGGC       CCAAAAGGAAGAGCTTCAGAGCCTGATGCACCAGCCCAAAGGGCTAGAGGAGGAGAATGCCCAGCTCC       GGGGGGCTCTGCAGCAGGGCGAAGCCTTCCAGCGGGCTCTGGAGTCAGAGCTGCAGCAGCTGCGGGCC       CGGCTCCAGGGGCTGGAGGCCGACTGTGTCCGGGGCCCAGATGGGGTGTGCCTCAGTGGGGATAGAGG       CCCACAGGGTGACAAGGCCATCAGGGAGCAAGGCCCCAGGGAGCAGGAGCCAGAACTCAGCTTCCTGA       AGCAGAAGGAACAGCTGGAGGCTGAGGCACAGGCATTAAGGCAAGAGTTAGAGAGGCAGCGACGGCTG       CTGGGGTCTGTACAGCAGGATCTGGAGAGGAGCTTGCAGGATGCCAGCCGCGGGGACCCAGCTCATGC       TGGCTTGGCTGAGCTGGGCCACAGATTGGCCCAGAAACTGCAGGGCCTGGAGAACTGGGGCCAGGACC       CTGGGGTCTCTGCCAATGCCTCAAAGGCCTGGCACCAGAAGTCCCACTTCCAGAATTCTAGGGAGTGG       AGTGGAAAGGAAAAGTGGTGGGATGGGCAGAGAGACCGGAAGGCTGAGCACTGGAAACATAAGAAGGA       AGAATCTGGCCGGGAAAGGAAGAAGAACTGGGGAGGTCAGGAGGACAGGGAGCCAGCAGGAAGGTGGA       AGGAGGGCAGGCCAAGGGTGGAGGAGTCGGGGAGCAAGAAGGAGGGCAAGCGACAGGGCCCGAAGGAA       CCCCCAAGGAAAAGTGGTAGCTTCCACTCCTCTGGAGAAAAGCAGAAGCAACCTCGGTGGAGGGAAGG       GACTAAGGACAGCCATGACCCCCTGCCATCCTGGGCAGAGCTGTTGAGGCCCAAGTACCGGGCACCCC       AGGGCTGCTCAGGTGTGGACGAGTGTGCCCGGCAGGAGGGCTTGACTTTCTTTGGCACAGAGCTAGCC       CCAGTGCGGCAACAGGAGCTGGCCTCTCTGCTAAGAACATACTTGGCACGGCTGCCCTGGGCTGGGCA       GCTGACCAAGGAGCTACCCCTCTCACCTGCTTTCTTTGGTGAGGATGGCATCTTCCGTCATGACCGCC       TCCGCTTCCGGGATTTTGTGGATGCCCTGGAGGACAGCTTGGAGGAGGTGGCTGTGCAACAGACAGGT       GATGATGATGAAGTA   T   ATGACTTTGAGGACTTCATCTTCAGCCACTTCTTTGGAGACAAAGCACTGAA       GAAGAGGCCTCTTCCTCCCCACAGGTCAGGGAAGAAGGACAAGCACTCACAGAGCCCAAGAGCTGCGG       GGCCCAGGGAGGGGCACAGCCATAGCCACCACCACCACCACCGGGGC TGA   CACCCTGCCCCACAGGGA           ATGGCCTTGGCCTGGCCCAGCCCAAGATCCCAGCGTTATCCAACTCCTGGAGGGTGGACTCTGTCCTG           GCTTGTTTGGTGTCCTCAGATAT                                           NOV16l, SNP13374624   SEQ ID NO: 456   737 aa   MW at 81446.5kD           of CG52171-04,   SNP Pos: 682       SNP Change:       Protein Sequence           Asp to Tyr                     MASCPDSDNSWVLAGSESLPVETLGPASRMDPESEHALQAPHSPSKTDGKELAGTMDGEGTLFQTESP           QSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKA       AWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALV       LLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLL       DKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQG       LEADCVRGPDGVCLSGDRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSV       KWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRK       SGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTELAPVRQ       QELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDE       VYDFEDFIFSHFFGDKALKKRPLPPHRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 16B.  
               TABLE 16B                       Comparison of the NOV16 protein sequences.                                            NOV16a   MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTNDGEG           NOV16b   ------------------------------------------------------------       NOV16c   MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEG       NOV16d   MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEG       NOV16e   ------------------------------------------------------------       NOV16f   MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEG               NOV16a   TLFQTESPQSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQD       NOV16b   ------------------------------------------------------------       NOV16c   TLFQTESPQSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQD       NOV16d   TLFQTESPQSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQD       NOV16e   ------------------------------------------------------------       NOV16f   TLFQTESPQSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQD               NOV16a   LEGQSPPQSLPSTPKAAWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVEN       NOV16b   ------------------------------------------------------------       NOV16c   LEGQSPPQSLPSTPKAAWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVEN       NOV16d   LEGQSPPQSLPSTPKAAWIREEGRCSSSDDDTDVDMEGLRRPRGREAGPPQPMVPLAVEN       NOV16e   ------------------------------------------------------------       NOV16f   LEGQSPPQSLPSTPKAAWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVEN               NOV16a   QAGGEGAGGELGISLNMCLLGALVLLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLE       NOV16b   ----------------MCLLGALVLLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLE       NOV16c   QAGGEGAGGELGISLNMCLLGALGLLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLE       NOV16d   QAGGEGAGGELGISLNMCLLGALGLLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLE       NOV16e   --------------------------------------ESETGPMEEVERQVLPDPEVLE       NOV16f   QAGGEGAGGELGISLNMCLLGALVLLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLE               NOV16a   AVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLM       NOV16b   AVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLM       NOV16c   AVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLM       NOV16d   AVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLM       NOV16e   AVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLM       NOV16f   AVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLM               NOV16a   HQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQGLEADCVRGPDGVCLSGDRGP       NOV16b   HQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQGLEADCVRGPDGVCLSGGRGP       NOV16c   HQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQGLEADCVRGPD----------       NOV16d   HQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQGLEADCVRGPDGVCLSGGRGP       NOV16e   HQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQGLEADCVRGPDGVCLSGDRGP       NOV16f   HQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARIQGLEADCVRGPDGVCLSGDRGP               NOV16a   QGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSVQQDLERSLQDAS       NOV16b   QGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSVQQDLERSLQDAS       NOV16c   ------------------------------------------------------------       NOV16d   QGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSVQQDLERSLQDAS       NOV16e   QGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSVQQDLERSLQDAS       NOV16f   QGDKAIREQGPREQEPELSFLNQKEQLEAEAQALRQELERQRRLLGSVQQDLERSLQDAS               NOV16a   RGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKEKWWD       NOV16b   RGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKEKWWD       NOV16c   ------------------------------------------------------------       NOV16d   RGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKEKWWD       NOV16e   RGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKEKWWD       NOV16f   RGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKEKWWD               NOV16a   GQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKE       NOV16b   GQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKE       NOV16c   ------------------------------------------------------------       NOV16d   GQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKE       NOV16e   GQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKE       NOV16f   GQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQAPKE               NOV16a   PPRKSGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGL       NOV16b   PPRKSGSFHSSGEKQKQPRWREGTKGSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGL       NOV16c   ------------------------------------------------------------       NOV16d   PPRKSGSFHSSGEKQKQPRWREGTKGSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGL       NOV16e   PPRKSGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGL       NOV16f   PPRKSGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGL               NOV16a   TFFGTELAPVRQQELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFV       NOV16b   TFFGTELAPVRQQELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFV       NOV16c   --------------------------------------------GDGIFRHDRLRFRDFV       NOV16d   TFFGTELAPVRQQELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFV       NOV16e   TFFGTELAPVRQQELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFV       NOV16f   TFFGTELAPVRQQELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFV               NOV16a   DALEDSLEEVAVQQTGDDDEVDDFEDFIFSHFFGDKALKKRPLPPHRSGKKDKHSQSPPA       NOV16b   DALEDSLEEVAVQQTGDDDEVDDFEDFIFSHFFGDKALKKR------SGKKDKHSQSPRA       NOV16c   DALEDSLEEVAVQQTGDDDEVDDFEDFIFSHFFGDKALKKR------SGKKDKHSQSPRA       NOV16d   DALEDSLEEVLEFSGR--------------------------------------------       NOV16e   DALEDSLEEVAVQQTGDDDEVDDFEDFIFSHFFGDKALKKR------SGKKDKHSQSPRA       NOV16f   DALEDSLEEVAVQQTGDDDEVDDFEDFIFSHFFGDKALKKR------SGKKDKHSQSPPA               NOV16a   AGPREGHSHSHHHHHRG       NOV16b   AGPREGHSHSHHHHHRG       NOV16c   AGPREGHSHSHHHHHRG       NOV16d   -----------------       NOV16e   AGPREGHSHSHHHHHRG       NOV16f   AGPREGHSHSHHHHRG-               NOV16a   (SEQ ID NO: 434)       NOV16b   (SEQ ID NO: 436)       NOV16c   (SEQ ID NO: 438)       NOV16d   (SEQ ID NO: 440)       NOV16e   (SEQ ID NO: 442)       NOV16f   (SEQ ID NO: 444)                  
 
      Further analysis of the NOV16a protein yielded the following properties shown in Table 16C.  
               TABLE 16C                       Protein Sequence Properties NOV16a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 8; pos. chg 0; neg. chg 2           H-region:   length 8; peak value 0.00           PSG score:   −4.40                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −7.85           possible cleavage site: between 23 and 24                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 197-213               −10.46                             PERIPHERAL   Likelihood = 9.34 (at 12)                         ALOM score: −10.46 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 204           Charge difference: −1.0 C(−4.0)-N(−3.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 2 (cytoplasmic tail 1 to 197)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   2.09           Hyd Moment(95):   1.02   G content:   0           D/E content:   2   S/T content:   2                         Score: −7.60       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: RRRR (5) at 160           pat4: KHKK (3) at 491           pat4: KKRP (4) at 699           pat7: none           bipartite: none           content of basic residues: 12.9%           NLS Score: 0.28       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions       263 S   0.81       264 L   0.87       265 Q   0.96       266 N   0.97       267 M   0.98       268 G   0.99       269 L   1.00       270 L   1.00       271 L   1.00       272 D   1.00       273 K   1.00       274 L   1.00       275 A   1.00       276 K   1.00       277 E   1.00       278 N   1.00       279 Q   1.00       280 D   1.00       281 I   1.00       282 R   1.00       283 L   1.00       284 L   1.00       285 Q   1.00       286 A   1.00       287 Q   1.00       288 L   1.00       289 Q   1.00       290 A   1.00       291 Q   1.00       292 K   1.00       293 E   1.00       294 E   1.00       295 L   1.00       296 Q   1.00       297 S   1.00       298 L   1.00       299 M   1.00       300 H   1.00       301 Q   1.00       303 K   0.71       304 G   0.71       305 L   0.87       306 E   0.87       307 E   0.87       308 E   0.87       309 N   0.87       310 A   0.87       311 Q   0.87       312 L   0.87       313 R   0.87       314 G   0.87       315 A   0.90       316 L   0.94       317 Q   0.94       318 Q   0.94       319 G   0.94       320 E   0.94       321 A   0.94       322 F   0.94       323 Q   0.94       324 R   0.94       325 A   0.94       326 L   0.94       327 E   0.94       328 S   0.94       329 E   0.94       330 L   0.94       331 Q   0.94       332 Q   0.94       333 L   0.94       334 R   0.94       335 A   0.94       336 R   0.94       337 L   0.94       338 Q   0.94       339 G   0.94       340 L   0.94       341 E   0.94       342 A   0.94       343 D   0.94       344 C   0.79       376 E   0.95       377 L   1.00       378 S   1.00       379 F   1.00       380 L   1.00       381 K   1.00       382 Q   1.00       383 K   1.00       384 E   1.00       385 Q   1.00       386 L   1.00       387 E   1.00       388 A   1.00       389 E   1.00       390 A   1.00       391 Q   1.00       392 A   1.00       393 L   1.00       394 R   1.00       395 Q   1.00       396 E   1.00       397 L   1.00       398 E   1.00       399 R   1.00       400 Q   1.00       401 R   1.00       402 R   1.00       403 L   1.00       404 L   1.00       405 G   1.00       406 S   1.00       407 V   1.00       408 Q   1.00       409 Q   1.00       410 D   1.00       411 L   1.00       412 E   1.00       413 R   1.00       414 S   0.99       415 L   0.94       416 Q   0.94       417 D   0.92       418 A   0.92       419 S   0.78       420 R   0.78       421 G   0.54           total: 127 residues                 Final Results (k = 9/23):                         39.1%: nuclear           26.1%: mitochondrial            8.7%: cytoplasmic            8.7%: Golgi            4.3%: plasma membrane            4.3%: vesicles of secretory system            4.3%: extracellular, including cell wall            4.3%: peroxisomal                 &gt;&gt; prediction for CG52171-04 is nuc (k = 23)                  
 
      A search of the NOV16a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 16D.  
               TABLE 16D                          Geneseq Results for NOV16a                                         NOV16a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               AAB93999   Human protein sequence SEQ ID   30 . . . 737    700/708 (98%)   0.0           NO: 14107 -  Homo sapiens , 702 aa.   1 . . . 702   700/708 (98%)           [EP1074617-A2, 07-FEB-2001]       ABG20800   Novel human diagnostic protein   7 . . . 700   624/697 (89%)   0.0           #20791 -  Homo sapiens , 669 aa.   2 . . . 668   634/697 (90%)           [WO200175067-A2, 11-OCT-2001]       AAB95336   Human protein sequence SEQ ID   1 . . . 566   564/566 (99%)   0.0           NO: 17611 -  Homo sapiens , 662 aa.   1 . . . 566   566/566 (99%)           [EP1074617-A2, 07-FEB-2001]       AAB62402   Human MBSP6 polypeptide (clone   197 . . . 737    533/541 (98%)   0.0           3207791.0.128) -  Homo sapiens , 535   1 . . . 535   533/541 (98%)           aa. [WO200127277-A2, 19-APR-2001]       AAB80449   Gene #23 associated peptide #1 -   17 . . . 397    375/381 (98%)   0.0             Homo sapiens , 451 aa.   8 . . . 388   377/381 (98%)           [WO200107459-A1, 01-FEB-2001]                  
 
      In a BLAST search of public sequence databases, the NOV16a protein was found to have homology to the proteins shown in the BLASTP data in Table 16E.  
               TABLE 16E                          Public BLASTP Results for NOV16a                                         NOV16a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q9HD85   Hematopoietic PBX-interacting   1 . . . 737   730/737 (99%)   0.0           protein -  Homo sapiens  (Human),   1 . . . 731   730/737 (99%)           731 aa.       Q96AQ6   Hematopoietic PBX-interacting   1 . . . 737   730/737 (99%)   0.0           protein -  Homo sapiens  (Human),   1 . . . 731   730/737 (99%)           731 aa.       Q9HA02   Hypothetical protein FLJ12435 -   30 . . . 737    700/708 (98%)   0.0             Homo sapiens  (Human), 702 aa.   1 . . . 702   700/708 (98%)       Q9H8X6   Hypothetical protein FLJ13157 -   1 . . . 566   564/566 (99%)   0.0             Homo sapiens  (Human), 662 aa.   1 . . . 566   566/566 (99%)       CAC43890   Sequence 11 from Patent   197 . . . 737    533/541 (98%)   0.0           WO0127277 -  Homo sapiens     1 . . . 535   533/541 (98%)           (Human), 535 aa.                  
 
      PFam analysis predicts that the NOV16a protein contains the domains shown in the Table 16F.  
               TABLE 16F                       Domain Analysis of NOV16a                                                        Pfam   NOV16a   Identities/   Expect           Domain   Match Region   Similarities   Value                   for the                   Matched Region                      
 
     Example 17.  
      The NOV17 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 17A.  
               TABLE 17A                       NOV17 Sequence Analysis                                                NOV17a, CG52534-06   SEQ ID NO: 457   1275 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 1273                       ATG GAGCGGCTTTGGGGTCTATTCCAGAGAGCGCAACAACTGTCCCCAAGATCCTCTCAGACCGTCTA           CCAGCGTGTGGAAGGCCCCCGGAAAGGGCACCTGGAGGAGGAAGAGGAAGACGGGGAGGAGGGGGCGG       AGACATTGGCCCACTTCTGCCCCATGGAGCTGAGGGGCCCTGAGCCCCTGGGCTCTAGACCCAGGCAG       CCAAACCTCATTCCCTGGGCGGCAGCAGGACGGAGGGCTGCCCCCTACCTGGTCCTGACGGCCCTGCT       GATCTTCACTGGGGCCTTCCTACTGGGCTACGTCGCCTTCCGAGGGTCCTGCCAGGCGTGCGGAGACT       CTGTGTTGGTGGTCAGTGAGGATGTCAACTATGAGCCTGACCTGGATTTCCACCAGGGCAGACTCTAC       TGGAGCGACCTCCAGGCCATGTTCCTGCAGTTCCTGGGGGAGGGGCGCCTGGAGGACACCATCAGGCA       AACCAGCCTTCGGGAACGGGTGGCAGGCTCGGCCGGGATGGCCGCTCTGACTCAGGACATTCGCGCGG       CGCTCTCCCGCCAGAAGCTGGACCACGTGTGGACCGACACGCACTACGTGGGGCTGCAATTCCCGGAT       CCGGCTCACCCCAACACCCTGCACTGGGTCGATGAGGCCGGGAAGGTCGGAGAGCAGCTGCCGCTGGA       GGACCCTGACGTCTACTGCCCCTACAGCGCCATCGGCAACGTCACGGGAGAGCTGGTGTACGCCCACT       ACGGGCGGCCCGAAGACCTGCAGGACCTGCGGGCCAGGGGCGTGGATCCAGTGGGCCGCCTGCTGCTG       GTGCGCGTGGGGGTGATCAGCTTCGCCCAGAAGGTGACCAATGCTCAGGACTTCGGGGCTCAAGGAGT       GCTCATATACCCAGAGCCAGCGGACTTCTCCCAGGACCCACCCAAGCCAAGCCTGTCCAGCCAGCAGG       CAGTGTATGGACATGTGCACCTGGGAACTGGAGACCCCTACACACCTGGCTTCCCTTCCTTCAATCAA       ACCCAGTTCCCTCCAGTTGCATCATCAGGCCTTCCCAGCATCCCAGCCCAGCCCATCAGTGCAGACAT       TGCCTCCCGCCTGCTGGACCACCTGCGGCTGCTGCGCTCCAACAGCTCCGGGACCCCCGGGGCCACCT       CCTCCACTGGCTTCCAGGAGAGCCGTTTCCGGCGTCAGCTAGCCCTGCTCACCTGGACGCTGCAAGGG       GCAGCCAATGCGCTTAGCGGGGATGTCTGGAACATTGATAACAACTTC TGA                                           NOV17a, CG52534-06   SEQ ID NO: 458   424aa   MW at 46603.7kD           Protein Sequence                     MERLWGLFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPEPLGSRPRQ           PNLIPWAAAGRRAAPYLVLTALLIFTGAFLLGYVAFRGSCQACGDSVLVVSEDVNYEPDLDFHQGRLY       WSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAALTQDIPAALSRQKLDHVWTDTHYVGLQFPD       PAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYSAIGNVTGELVYAHYGRPEDLQDLRARGVDPVGRLLL       VRVGVISFAQKVTNAQDFGAQGVLIYPEPADFSQDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQ       TQFPPVASSGLPSIPAQPISADIASRLLDHLRLLRSNSSGTPGATSSTGFQESRFRRQLALLTWTLQG       AANALSGDVWNIDNNF                                     NOV17b, CG52534-01   SEQ ID NO: 459   2857 bp           DNA Sequence   ORF Start: ATG at 28   ORF Stop: TGA at 1495                       CTGCAGGCTTCAGGAGGGGACACAAGC   ATG GAGCGGCTTTGGGGTCTATTCCAGAGAGCGCAACAACT           GTCCCCAAGATCCTCTCAGACCGTCTACCAGCGTGTGGAAGGCCCCCGGAAAGGGCACCTGGAGGAGG       AAGAGGAAGACGGGGAGGAGGGGGCGGAGACATTGGCCCACTTCTGCCCCATGGAGCTGAGGGGCCCT       GAGCCCCTGGGCTCTAGACCCAGGCAGCCAAACCTCATTCCCTGGGCGGCAGCAGGACGGAGGGCTGC       CCCCTACCTGGTCCTGACGGCCCTGCTGATCTTCACTGGGGCCTTCCTACTGGGCTACGTCGCCTTCC       GAGGGTCCTGCCAGGCGTGCGGAGACTCTGTGTTGGTGGTCAGTGAGGATGTCAACTATGAGCCTGAC       CTGGATTTCCACCAGGGCAGACTCTACTGGAGCGACCTCCAGGCCATGTTCCTGCAGTTCCTGGGGGA       GGGGCGCCTGGAGGACACCATCAGGCAAACCAGCCTTCGGGAACGGGTGGCAGGCTCGGCCGGGATGG       CCGCTGCTGACTCAGGACATTCGCGCGGCCTCTCCCGCCAGAAGCTGGACCACGTGTGGACCGACACG       CACTACGTGGGGCTGCAATTCCCGGATCCGGCTCACCCCAACACCCTGCACTGGGTCGATGAGGCCGG       GAAGGTCGGAGAGCAGCTGCCGCTGGAGGACCCTGACGTCTACTGCCCCTACAGCGCCATCGGCAACG       TCACGGGAGAGCTGGTGTACGCCCACTACGGGCGGCCCGAAGACCTGCAGGACCTGCGGGCCAGGGGC       GTGGATCCAGTGGGCCGCCTGCTGCTGGTGCGCGTGGGGGTGATCAGCTTCGCCCAGAAGGTGACCAA       TGCTCAGGACTTCGGGGCTCAAGGAGTGCTCATATACCCAGAGCCAGCGGACTTCTCCCAGGACCCAC       CCAAGCCAAGCCTGTCCAGCCAGCAGGCAGTGTATGGACATGTGCACCTGGGAACTGGAGACCCCTAC       ACACCTGGCTTCCCTTCCTTCAATCAAACCCAGTTCCCTCCAGTTGCATCATCAGGCCTTCCCAGCAT       CCCACGCCGAGCCCTATGGAGTCTCAAAAAAAAAAAGGGCCCCGGGCCACGACTGCGGCTAGTGGTCA       ACAATCACAGGACCTCCACCCCCATCAACAACATCTTCGGCTGCATCGAAGGCCGCTCAGAGCCAGAT       CACTACGTTGTCATCGGGGCCCAGAGGGATGCATGGGGCCCAGGAGCAGCTAAATCCGCTGTGGGGAC       GGCTATACTCCTGGAGCTGGTGCGGACCTTTTCCTCCATGGTGAGCAACGGCTTCCGGCCCCGCAGAA       GTCTCCTCTTCATCAGCTGGGACGGTGGTGACTTTGGAAGCGTGGGCTCCACGGAGTGGCNTAGAGGG       CTACCTCAGCGTGCTGCACCTCAAAGCCGTAGTGTACGTGAGCCTGGACAACGCAGTGAAGGGGGA TG           A   CAAGTTTCATGCCAAGACCAACCCCCTTCTGACAAGTCTCATTGAGAAGTGTCCTGAAGCAGATGGA           TTCTCCCAACCACAGTGGGCAGACTCTCTATGAACAGGTGGGGTTCACCAATTCCCAGCTGGGATTGC           TGAGGTGATCCGGCCCCTACCCATGGGACAGCAGTGCCTATTTCCTTCACGGGCCTTTGTTGGGGAGT           CCCTTGCCCTTCGAGTTCTTCCTTTTATTGGAGGGACGGACCAGGCCTTACCCATTTCCTTGCACAAA           AAGGGAGGGACACTTATTGGAGGAACCTGCAGTAAGGTGCTGCAAGGCCGCCTGCCCGCCGTGGCCCA           GGCCGTGGCCCAGCTCGCAGGGCAGCTCCTCATCCGGCTCAGCCACGATCGCCTGCTGCCCCTCGACT           TCGGCCGCTACGGGGACGTCGTCCTCAGGCACATCGGGAACCTCAACGAGTTCTCTGGGGACCTCAAG           CCCGCGGGCTGACCCTGCAGTGGGTGTACTCGGCGCGGGGGGACTACATCCGGGCGGCGGAAAAGCTG           CGGCAGGTAGATCTACTTGCCGCAGCTCGGAGGAGAGAGACGAGCGACTGACACGCATGTACAACGTC           CGCATAATGCGGGTGGAGTTCTACTTCCTTTCCCAGTACGTGTCGCCAGCCGACTCCCCGTTCCGCCA           CATCTTCATGGGCCGTGGAGACCACACGCTGGGCGCCCTGCTGGACCACCTGCGGCTGCTGCACTCCA           ACAGCTCCGGGACCCCCGGGGCCACCTCCTCCACTGGCTTCCAGGGAGAGCCGTTTCCGGGTCGTCAG           CTAGCCCTGCTCACCTGGACGCTGCAAGGGGCAGCCAATGCGCTTAGCGGGGATGTCTGGAACATTGA           TAACAACTTCTGAGGCCCTGGGGATCCTCAAATCCCCGTCCCCCAGTCAAGAGCTCCTCTGCTCCTCG           CTTGAATGATTCAGGGTCAGGGAGGTGGCTCAGAGTCCACCTCTCATTGCTGATCAATTTCTCATTAC           CCCTACACATCTCTCCACGGAGCCCAGACCCCAGCACAGATATCCACACACCCCAGCCCTGCAGTGTA           GCTGACCCTAATGTGACGGTCATACTGTCGGTTAATCAGAGAGTAGCATCCCTTCAATCACAGCCCCT           TCCCCTTTCTGGGGTCCTCCATACCTAGAGACCACTCTGGGAGGTTTGCTAGGCCCTGGGACCTGGCC           AGCTCTGTTAGTGGGAGAGATCGCTGGCACCATAGCCTTATGGCCAACAGGTGGTCTGTGGTGAAAGG           GGCGTGGAGTTTCAATATCAATAAACCACCTGATATCAATAAAAAAAAAAAAAAAAAAAAAAAAAAAA           A                                           NOV17b, CG52534-01   SEQ ID NO: 460   489 aa   MW at 53555.7kD           Protein Sequence                     MERLWGLFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPEPLGSRPRQ           PNLIPWAAAGRRAAPYLVLTALLIFTGAFLLGYVAFRGSCQACGDSVLVVSEDVNYEPDLDFHQGRLY       WSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAAADSGHSRGLSRQKLDHVWTDTHYVGLQFPD       PAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYSAIGNVTGELVYAHYGRPEDLQDLRARGVDPVGRLLL       VRVGVISFAQKVTNAQDFGAQGVLIYPEPADFSQDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQ       TQFPPVASSGLPSIPRRALWSLKKKKGPGPRLRLVVNNHRTSTPINNIFGCIEGRSEPDHYVVIGAQR       DAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISWDGGDFGSVGSTEWXRGLPQRAAPQS       RSVREPGQRSEGG                                     NOV17c, CG52534-02   SEQ ID NO: 461   865 bp           DNA Sequence   ORF Start: ATG at 27   ORF Stop: TGA at 837                       TGCGCGCGGATTCTGCTTCTCAGAAG   ATG CACTATTATAGATACTCTAACGCCAAGGTCAGCTGCTGG           TACAAGTACCTCCTTTTCAGCTACAACATCATCTTCTGGTTGGCTGGAGTTGTCTTCCTTGGAGTCGG       GCTGTGGGCATGGAGCGAAAAGGGTGTGCTGTCCGACCTCACCAAAGTGACCCGGATGCATGGAATCG       ACCCTGTGGTGCTGGTCCTGATGGTGGGCGTGGTGATGTTCACCCTGGGGTTCGCCGGCTGCGTGGGG       GCTCTGCGGGAGAATATCTGCTTGCTCAACTTTTTCTGTGGCACCATCGTGCTCATCTTCTTCCTGGA       GCTGGCTGTGGCCGTGCTGGCCTTCCTGTTCCAGGACTGGGTGAGGGACCGGTTCCGGGAGTTCTTCG       AGAGCAACATCAAGTCCTACCGGGACGATATCGATCTGCAAAACCTCATCGACTCCCTTCAGAAAGCT       AACCAGTGCTGTGGCGCATATGGCCCTGAAGACTGGGACCTCAACGTCTACTTCAATTGCAGCGGTGC       CAGCTACAGCCGAGAGAAGTGCGGGGTCCCCTTCTCCTGCTGCGTGCCAGATCCTGTGCAAAAAGTTG       TGAACACACAGTGTGGATATGATGTCAGGATTCAGCTGAAGAGCAAGTGGGATGAGTCCATCTTCACG       AAAGGCTGCATCCAGGCGCTGGAAAGCTGGCTCCCGCGGAACATTTACATTGTGGCTGGCGTCTTCAT       CGCCATCTCGCTGTTGCAGATATTTGGCATCTTCCTGGCAAGGACGCTGATCTCAGACATCGAGGCAG       TGAAGGCCGGCCATCACTTC TGA   GGAGCAGAGTTGAGGGAGCCGAGCTA                                           NOV17c, CG52534-02   SEQ ID NO: 462   270 aa   MW at 30718.5kD           Protein Sequence                     MHYYRYSNAKVSCWYKYLLFSYNIIFWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGIDPVVLVLMV           GVVMFTLGFAGCVGALRENICLLNFFCGTIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRD       DIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPVQKVVNTQCGYDV       RIQLKSKWDESIFTKGCIQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLISDIEAVKAGHHF                                     NOV17d, CG52534-03   SEQ ID NO: 463   863 bp           DNA Sequence   ORF Start: ATG at 26   ORF Stop: TGA at 836                       GCGCGCGGATTCTGCTTCTCAGAAG   ATG CACTATTATAGATACTCTAACGCCAAGGTCAGCTGCTGGT           ACAAGTACCTCCTTTTCAGCTACAACATCATCTTCTGGTTGGCTGGAGTTGTCTTCCTTGGAGTCGGG       CTGTGGGCATGGAGCGAAAAGGGTGTGCTGTCCGACCTCACCAAAGTGACCCGGATGCATGGAATCGA       CCCTGTGGTGCTGGTCCTGATGGTGGGCGTGGTGATGTTCACCCTGGGGTTCGCCGGCTGCGTGGGGG       CTCTGCGGGAGAATATCTGCTTGCTCAACTTTTTCTGTGGCACCATCGTGCTCATCTTCTTCCTGGAG       CTGGCTGTGGCCGTGCTGGCCTTCCTGTTCCAGGACTGGGTGAGGGACCGGTTCCGGGAGTTCTTCGA       GAGCAACATCAAGTCCTACCGGGACGATATCGATCTGCAAAACCTCATCGACTCCCTTCAGAAAGCTA       ACCAGTGCTGTGGCGCATATGGCCCTGAAGACTGGGACCTCAACGTCTACTTCAATTGCAGCGGTGCC       AGCTACAGCCGAGAGAAGTGCGGGGTCCCCTTCTCCTGCTGCGTGCCAGATCCTGCGCAAAAAGTTGT       GAACACACAGTGTGGATATGATGTCAGGATTCAGCTGAAGAGCAAGTGGGATGAGTCCATCTTCACGA       AAGGCTGCATCCAGGCGCTGGAAAGCTGGCTCCCGCGGAACATTTACATTGTGGCTGGCGTCTTCATC       GCCATCTCGCTGTTGCAGATATTTGGCATCTTCCTGGCAAGGACGCTGATCTCAGACATCGAGGCAGT       GAAGGCCGGCCATCACTTC TGA   GGAGCAGAGTTGAGGGAGCCGAGCT                                           NOV17d, CG52534-03   SEQ ID NO: 464   270 aa   MW at 30690.5kD           Protein Sequence                     MHYYRYSNAKVSCWYKYLLFSYNIIFWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGIDPVVLVLMV           GVVMFTLGFAGCVGALRENICLLNFFCGTIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRD       DIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDV       RIQLKSKWDESIFTKGCIQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLISDIEAVKAGHHF                                     NOV17e, CG52534-04   SEQ ID NO: 465   2406 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 2404                       ATG GAGCGGCTTTGGGGTCTATTCCAGAGAGCGCAACAACTGTCCCCAAGATCCTCTCAGACCGTCTA           CCAGCGTGTGGAAGGCCCCCGGAAAGGGCACCTGGAGGAGGAAGAGGAAGACGGGGAGGAGGGGGCGG       AGACATTGGCCCACTTCTGCCCCATGGAGCTGAGGGGCCCTGAGCCCCTGGGCTCTAGACCCAGGCAG       CCAAACCTCATTCCCTGGGCGGCAGCAGGACGGAGGGCTGCCCCCTACCTGGTCCTGACGGCCCTGCT       GATCTTCACTGGGGCCTTCCTACTGGGCTACGTCGCCTTCCGAGGGTCCTGCCAGGCGTGCGGAGACT       CTGTGTTGGTGGTCAGTGAGGATGTCAACTATGAGCCTGACCTGGATTTCCACCAGGGCAGACTCTAC       TGGAGCGACCTCCAGGCCATGTTCCTGCAGTTCCTGGGGGAGGGGCGCCTGGAGGACACCATCAGGCA       AACCAGCCTTCGGGAACGGGTGGCAGGCTCGGCCGGGATGGCCGCTCTGACTCAGGACATTCGCGCGG       CGCTCTCCCGCCAGAAGCTGGACCACGTGTGGACCGACACGCACTACGTGGGGCTGCAATTCCCGGAT       CCGGCTCACCCCAACACCCTGCACTGGGTCGATGAGGCCGGGAAGGTCGGAGAGCAGCTGCCGCTGGA       GGACCCTGACGTCTACTGCCCCTACAGCGCCATCGGCAACGTCACGGGAGAGCTGGTGTACGCCCACT       ACGGGCGGCCCGAAGACCTGCAGGACCTGCGGGCCAGGGGCGTGGATCCAGTGGGCCGCCTGCTGCTG       GTGCGCGTGGGGGTGATCAGCTTCGCCCAGAAGGTGACCAATGCTCAGGACTTCGGGGCTCAAGGAGT       GCTCATATACCCAGAGCCAGCGGACTTCTCCCAGGACCCACCCAAGCCAAGCCTGTCCAGCCAGCAGG       CAGTGTATGGACATGTGCACCTGGGAACTGGAGACCCCTACACACCTGGCTTCCCTTCCTTCAATCAA       ACCCAGTTCCCTCCAGTTGCATCATCAGGCCTTCCCAGCATCCCAGCCCAGCCCATCAGTGCAGACAT       TGCCTCCCGCCTGCTGAGGAAGCTCAAAGGCCCTGTGGCCCCCCAAGAATGGCAGGGGAGCCTCCTAG       GCTCCCCTTATCACCTGGGCCCCGGGCCACGACTGCGGCTAGTGGTCAACAATCACAGGACCTCCACC       CCCATCAACAACATCTTCGGCTGCATCGAAGGCCGCTCAGAGCCAGATCACTACGTTGTCATCGGGGC       CCAGAGGGATGCATGGGGCCCAGGAGCAGCTAAATCCGCTGTGGGGACGGCTATACTCCTGGAGCTGG       TGCGGACCTTTTCCTCCATGGTGAGCAACGGCTTCCGGCCCCGCAGAAGTCTCCTCTTCATCAGCTGG       GACGGTGGTGACTTTGGAAGCGTGGGCTCCACGGAGTGGCTAGAAGGCTACCTCAGCGTGCTGCACCT       CAAAGCCGTAGTGTACGTGAGCCTGGACAACGCAGTGCTGGGGGATGACAAGTTTCATGCCAAGACCA       GCCCCCTTCTGACAAGTCTCATTGAGAGTGTCCTGAAGCAGGTGGATTCTCCCAACCACAGTGGGCAG       ACTCTCTATGAACAGGTGGTGTTCACCAATCCCAGCTGGGATGCTGAGGTGATCCGGCCCCTACCCAT       GGACAGCAGTGCCTATTCCTTCACGGCCTTTGTGGGAGTCCCTGCCGTCGAGTTCTCCTTTATGGAGG       ACGACCAGGCCTACCCATTCCTGCACACAAAGGAGGACACTTATGAGAACCTGCATAAGGTGCTGCAA       GGCCGCCTGCCCGCCGTGGCCCAGGCCGTGGCCCAGCTCGCAGGGCAGCTCCTCATCCGGCTCAGCCA       CGATCGCCTGCTGCCCCTCGACTTCGGCCGCTACGGGGACGTCGTCCTCAGGCACATCGGGAACCTCA       ACGAGTTCTCTGGGGACCTCAAGGCCCGCGGGCTGACCCTGCAGTGGGTGTACTCGGCGCGGGGGGAC       TACATCCGGGCGGCGGAAAAGCTGCGGCAGGAGATCTACAGCTCGGAGGAGAGAGACGAGCGACTGAC       ACGCATGTACAACGTGCGCATAATGCGGGTGGAGTTCTACTTCCTTTCCCAGTACGTGTCGCCAGCCG       ACTCCCCGTTCCGCCACATCTTCATGGGCCGTGGAGACCACACGCTGGGCGCCCTGCTGGACCACCTG       CGGCTGCTGCGCTCCAACAGCTCCGGGACCCCCGGGGCCACCTCCTCCACTGGCTTCCAGGAGAGCCG       TTTCCGGCGTCAGCTAGCCCTGCTCACCTGGACGCTGCAAGGGGCAGCCAATGCGCTTAGCGGGGATG       TCTGGAACATTGATAACAACTTC TGA                                           NOV17e, CG52534-04   SEQ ID NO: 466   801 aa   MW at 88754.1kD           Protein Sequence                     MERLWGLFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPEPLGSRPRQ           PNLIPWAAAGRRAAPYLVLTALLIFTGAFLLGYVAFRGSCQACGDSVLVVSEDVNYEPDLDFHQGRLY       WSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAALTQDIPAALSRQKLDHVWTDTHYVGLQFPD       PAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYSAIGNVTGELVYAHYGRPEDLQDLRARGVDPVGRLLL       VRVGVISFAQKVTNAQDFGAQGVLIYPEPADFSQDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQ       TQFPPVASSGLPSIPAQPISADIASRLLRKLKGPVAPQEWQGSLLGSPYHLGPGPRLRLVVNNHRTST       PINNIFGCIEGRSEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISW       DGGDFGSVGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQVDSPNHSGQ       TLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAFVGVPAVEFSFMEDDQAYPFLHTKEDTYENLHKVLQ       GRLPAVAQAVAQLAGQLLIRLSHDRLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTLQWVYSARGD       YIRAAEKLRQEIYSSEERDERLTRMYNVRIMRVEFYFLSQYVSPADSPFRHIFMGRGDHTLGALLDHL       RLLRSNSSGTPGATSSTGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF                                     NOV17f, CG52534-05   SEQ ID NO: 467   2531 bp           DNA Sequence   ORF Start: ATG at 65   ORF Stop: TGA at 2468                       CTGCAGGCTTCAGGAGGGGTACTCTGCCTTCTGGACACTGCAGGCTTCAGGAGGGGACACAAGC   ATG G           AGCGGCTTTGGGGTCTATTCCAGAGAGCGCAACAACTGTCCCCAAGATCCTCTCAGACCGTCTACCAG       CGTGTGGAAGGCCCCCGGAAAGGGCACCTGGAGGAGGAAGAGGAAGACGGGGAGGAGGGGGCGGAGAC       ATTGGCCCACTTCTGCCCCATGGAGCTGAGGGGCCCTGAGCCCCTGGGCTCTAGACCCAGGCAGCCAA       ACCTCATTCCCTGGGCGGCAGCAGGACGGAGGGCTGCCCCCTACCTGGTCCTGACGGCCCTGCTGATC       TTCACTGGGGCCTTCCTACTGGGCTACGTCGCCTTCCGAGGGTCCTGCCAGGCGTGCGGAGACTCTGT       GTTGGTGGTCAGTGAGGATGTCAACTATGAGCCTGACCTGGATTTCCACCAGGGCAGACTCTACTGGA       GCGACCTCCAGGCCATGTTCCTGCAGTTCCTGGGGGAGGGGCGCCTGGAGGACACCATCAGGCAAACC       AGCCTTCGGGAACGGGTGGCAGGCTCGGCCGGGATGGCCGCTCTGACTCAGGACATTCGCGCGGCGCT       CTCCTGCCAGAAGCTGGACCACGTGTGGACCGACACGCACTACGTGGGGCTGCAATTCCCGGATCCGG       CTCACCCCAACACCCTGCACTGGGTCGATGAGGCCGGGAAGGTCGGAGAGCAGCTGCCGCTGGAGGAC       CCTGACGTCTACTGCCCCTACAGCGCCATCGGCAACGTCACGGGAGAGCTGGTGTACGCCCACTACGG       GCGGCCCGAAGACTTGCAGGACCTGCGGGCCAGGGGCGTGGATCCAGTGGGCCGCCTGCTGCTGGTGC       GCGTGGGGGTGATCAGCTTCGCCCAGAAGGTGACCAATGCTCAGGACTTCGGGGCTCAAGGAGTGCTC       ATATACCCAGAGCCAGCGGACTTCTCCCAGGACCCACCCAAGCCAAGCCTGTCCAGCCAGCAGGCAGT       GTATGGACATGTGCACCTGGGAACTGGGGACCCCTACACACCTGGCTTCCCTTCCTTCAATCAAACCC       AGTTCCCTCCAGTTGCATCATCAGGCCTTCCCAGCATCCCAGCCCAGCCCATCAGTGCAGACATTGCC       TCCCGCCTGCTGAGGAAGCTCAAAGGCCCTGTGGCCCCCCAAGAATGGCAGGGGAGCCTCCTAGGCTC       CCCTTATCACCTGGGCCCCGGGCCACGACTGCGGCTAGTGGTCAACAATCACAGGACCTCCACCCCCA       TCAACAACATCTTCGGCTGCATCGAAGGCCGCTCAGAGCCAGATCACTACGTTGTCATCGGGGCCCAG       AGGGATGCATGGGGCCCAGGAGCAGCTAAATCCGCTGTGGGGACGGCTATACTCCTGGAGCTGGTGCG       GACCTTTTCCTCCATGGTGAGCAACGGCTTCCGGCCCCGCAGAAGTCTCCTCTTCATCAGCTGGGACG       GTGGTGACTTTGGAAGCGTGGGCTCCACGGAGTGGCTAGAGGGCTACCTCAGCGTGCTGCACCTCAAA       GCCGTAGTGTACGTGAGCCTGGACAACGCAGTGCTGGGGGATGACAAGTTTCATGCCAAGACCAGCCC       CCTTCTGACAAGTCTCATTGAGAGTGTCCTGAAGCAGGTGGATTCTCCCAACCACAGTGGGCAGACTC       TCTATGAACAGGTGGTGTTCACCAATCCCAGCTGGGATGCTGAGGTGATCCGGCCCCTACCCATGGAC       AGCAGTGCCTATTCCTTCACGGCCTTTGTGGGAGTCCCTGCCGTCGAGTTCTCCTTTATGGAGGACGA       CCAGGCCTACCCATTCCTGCACACAAAGGAGGACACTTATGAGAACCTGCATAAGGTGCTGCAAGGCC       GCCTGCCCGCTGTGGCCCAGGCCGTGGCCCAGCCCGCAGGGCAGCTCCTCATCCGGCTCAGCCACGAT       CGCCTGCTGCCCCTCGACTTCGGCCGCTACGGGGACGTCGTCCTCAGGCACATCGGGAACCTCAACGA       GTTCTCTGGGGACCTCAAGGCCCGCGGGCTGACCCTGCAGTGGGTGTACTCGGCGCGGGGGGACTACA       TCCGGGCGGCGGAAAAGCTGCGGCAGGAGATCTACAGCTCGGAGGAGAGAGACGAGCGACTGACACGC       ATGTACAACGTGCGCATAATGCGGGTGGAGTTCTACTTCCTTTCCCAGTACGTGTCGCCAGCCGACTC       CCCGTTCCGCCACATCTTCATGGGCCGTGGAGACCACACGCTGGGCGCCCTGCTGGACCACCTGCGGC       TGCTGCGCTCCAACAGCTCCGGGACCCCCGGGGCCACCTCCTCCACTGGCTTCCAGGAGAGCCGTTTC       CGGCGTCAGCTAGCCCTGCTCACCTGGACGCTGCAAGGGGCAGCCAATGCGCTTAGCGGGGATGTCTG       GAACATTGATAACAACTTC TGA   GGCCCTGGGGATCCTCACATCCCCGTCCCCCAGTCAAGAGCTCCTC           TGCACCTCGACTTGA                                           NOV17f, CG52534-05   SEQ ID NO: 468   801 aa   MW at 88685.0kD           Protein Sequence                     MERLWGLFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPEPLGSRPRQ           PNLIPWAAAGRRAAPYLVLTALLIFTGAFLLGYVAFRGSCQACGDSVLVVSEDVNYEPDLDFHQGRLY       WSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAALTQDIRAALSCQKLDHVWTDTHYVGLQFPD       PAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYSAIGNVTGELVYAHYGRPEDLQDLRARGVDPVGRLLL       VRVGVISFAQKVTNAQDFGAQGVLIYPEPADFSQDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQ       TQFPPVASSGLPSIPAQPISADIASRLLRKLKGPVAPQEWQGSLLGSPYHLGPGPRLRLVVNNHRTST       PINNIFGCIEGRSEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISW       DGGDFGSVGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQVDSPNHSGQ       TLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAFVGVPAVEFSFMEDDQAYPFLHTKEDTYENLHKVLQ       GRLPAVAQAVAQPAGQLLIRLSHDRLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTLQWVYSARGD       YIRAAEKLRQEIYSSEERDEPLTRMYNVRIMRVEFYFLSQYVSPADSPFRHIFMGRGDHTLGALLDHL       RLLRSNSSGTPGATSSTGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 17B.  
               TABLE 17B                       Comparison of the NOV17 protein sequences.                                            NOV17a   MERLWGLFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPE           NOV17b   MERLWGLFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPE       NOV17c   --------MHYYRYSNAKVSCWYKYLLFSYNIIFWLA---G-------VVFLGVGLWAWS       NOV17d   --------MHYYRYSNAKVSCWYKYLLFSYNIIFWLA---G-------VVFLGVGLWAWS       NOV17e   MERLWGLFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPE       NOV17f   MERLWGLFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPE               NOV17a   PLGSRPRQPNLIPWAAAGRRAAPYLVLTALLIFTGAFLLGYVAFRG-SCQA---CGDSVL       NOV17b   PLGSRPRQPNLIPWAAAGRRAAPYLVLTALLIFTGAFLLGYVAFRG-SCQA---CGDSVL       NOV17c   EKGVLSDLTKVT--RMHGIDPVVLVLMVGVVMFTLGFAGCVGALRENICLLNFFCGTIVL       NOV17d   EKGVLSDLTKVT--RMHGIDPVVLVLMVGVVMFTLGFAGCVGALRENICLLNFFCGTIVL       NOV17e   PLGSRPRQPNLIPWAAAGRRAAPYLVLTALLIFTGAFLLGYVAFRG-SCQA---CGDSVL       NOV17f   PLGSRPRQPNLIPWAAAGRRAAPYLVLTALLIFTGAFLLGYVAFRG-SCQA---CGDSVL               NOV17a   VVSEDVNYEPDLDFHQGRLYWSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAALT       NOV17b   VVSEDVNYEPDLDFHQGRLYWSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAAAD       NOV17c   IFFLELAVA-VLAFLF--QDW--VRDRFREFF-----ESNIK--SYRDDIDLQNLIDSLQ       NOV17d   IFFLELAVA-VLAFLF--QDW--VRDRFREFF-----ESNIK--SYRDDIDLQNLIDSLQ       NOV17e   VVSEDVNYEPDLDFHQGRLYWSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAALT       NOV17f   VVSEDVNYEPDLDFHQGRLYWSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAALT               NOV17a   QDIRAALSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYS       NOV17b   SGHSRGLSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYS       NOV17c   KANQCCGAYGPED--WDLNVYFNCSGASYSREKCGVPFSCCVPDPVQKVV---NTQCGYD       NOV17d   KANQCCGAYGPED--WDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVV---NTQCGYD       NOV17e   QDIRAALSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYS       NOV17f   QDIRAALSCQKLDHVWTDTHYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYS               NOV17a   AIGNVTGELVYAHYGRPEDLQDLRARGVDPVGRLLLVRVGVISFAQKVTNAQDFGAQGVL       NOV17b   AIGNVTGELVYAHYGRPEDLQDLRARGVDPVGRLLLVRVGVISFAQKVTNAQDFGAQGVL       NOV17c   VRIQLKSKWDESIFTKGC-IQALESW--LP--RNIYIVAGV--FIA-ISLLQIFG-----       NOV17d   VRIQLKSKWDESIFTKGC-IQALESW--LP--RNIYIVAGV--FIA-ISLLQIFG-----       NOV17e   AIGNVTGELVYAHYGRPEDLQDLRARGVDPVGRLLLVRVGVISFAQKVTNAQDFGAQGVL       NOV17f   AIGNVTGELVYAHYGRPEDLQDLRARGVDPVGRLLLVRVGVISFAQKVTNAQDFGAQGVL               NOV17a   IYPEPADFSQDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVASSGLPSIPA       NOV17b   IYPEPADFSQDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVASSGLPSIPR       NOV17c   IFLARTLIS-D--IEAVK--A---GH-HF-------------------------------       NOV17d   IFLARTLIS-D--IEAVK--A---GH-HF-------------------------------       NOV17e   IYPEPADFSQDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVASSGLPSIPA       NOV17f   IYPEPADFSQDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVASSGLPSIPA               NOV17a   QPISADIASRLLDHLRLLRSNSSGTPGATSSTGFQESRFRRQLALLTWTLQGAANALSGD       NOV17b   R------ALWSLKKKKGP---------------G----PRLRLVVNNHRTSTPINNIFGC       NOV17c   ------------------------------------------------------------       NOV17d   ------------------------------------------------------------       NOV17e   QPISADIASRLLRKLKGPVAPQEWQGSLLGSPYHLGPGPRLRLVVNNHRTSTPINNIFGC       NOV17f   QPISADIASRLLRKLKGPVAPQEWQGSLLGSPYHLGPGPRLRLVVNNHRTSTPINNIFGC               NOV17a   VWNIDNNF----------------------------------------------------       NOV17b   IEGRSEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISW       NOV17c   ------------------------------------------------------------       NOV17d   ------------------------------------------------------------       NOV17e   IEGRSEPDHYVVIGAQRDAWGPGAAXSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISW       NOV17f   IEGRSEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISW               NOV17a   ------------------------------------------------------------       NOV17b   DGGDFGSVGSTEWXRGLPQRAAPQSRSVREPGQRSEGG----------------------       NOV17c   ------------------------------------------------------------       NOV17d   ------------------------------------------------------------       NOV17e   DGGDFGSVGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQV       NOV17f   DGGDFGSVGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQV               NOV17a   ------------------------------------------------------------       NOV17b   ------------------------------------------------------------       NOV17c   ------------------------------------------------------------       NOV17d   ------------------------------------------------------------       NOV17e   DSPNHSGQTLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAFVGVPAVEFSFMEDDQAYPF       NOV17f   DSPNHSGQTLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAFVGVPAVEFSFMEDDQAYPF               NOV17a   ------------------------------------------------------------       NOV17b   ------------------------------------------------------------       NOV17c   ------------------------------------------------------------       NOV17d   ------------------------------------------------------------       NOV17e   LHTKEDTYENLHKVLQGRLPAVAQAVAQLAGQLLIRLSHDRLLPLDFGRYGDVVLRHIGN       NOV17f   LHTKEDTYENLHKVLQGRLPAVAQAVAQPAGQLLIRLSHDRLLPLDFGRYGDVVLRHIGN               NOV17a   ------------------------------------------------------------       NOV17b   ------------------------------------------------------------       NOV17c   ------------------------------------------------------------       NOV17d   ------------------------------------------------------------       NOV17e   LNEFSGDLKARGLTLQWVYSARGDYIRAAEKLRQEIYSSEERDERLTRMYNVRIMRVEFY       NOV17f   LNEFSGDLKARGLTLQWVYSARGDYIRAAEKLRQEIYSSEERDERLTRMYNVRIMRVEFY               NOV17a   ------------------------------------------------------------       NOV17b   ------------------------------------------------------------       NOV17c   ------------------------------------------------------------       NOV17d   ------------------------------------------------------------       NOV17e   FLSQYVSPADSPFRHIFMGRGDHTLGALLDHLRLLRSNSSGTPGATSSTGFQESRFRRQL       NOV17f   FLSQYVSPADSPFRHIFMGRGDHTLGALLDHLRLLRSNSSGTPGATSSTGFQESRFRRQL               NOV17a   -------------------------       NOV17b   -------------------------       NOV17c   -------------------------       NOV17d   -------------------------       NOV17e   ALLTWTLQGAANALSGDVWNIDNNF       NOV17f   ALLTWTLQGAANALSGDVWNIDNNF               NOV17a   (SEQ ID NO: 458)       NOV17b   (SEQ ID NO: 460)       NOV17c   (SEQ ID NO: 462)       NOV17d   (SEQ ID NO: 464)       NOV17e   (SEQ ID NO: 466)       NOV17f   (SEQ ID NO: 468)                  
 
      Further analysis of the NOV17a protein yielded the following properties shown in Table 17C.  
               TABLE 17C                       Protein Sequence Properties NOV17a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 10; pos. chg 2; neg. chg 1           H-region:   length 6; peak value −7.91           PSG score:   −12.31                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −6.46           possible cleavage site: between 16 and 17                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 86-102               −5.68                             PERIPHERAL   Likelihood = 1.54 (at 264)                         ALOM score: −5.68 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 93           Charge difference: −3.0 C(0.0)-N(3.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 2 (cytoplasmic tail 1 to 86)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:    4   Hyd Moment(75):   8.36           Hyd Moment(95):   11.20   G content:   1           D/E content:    2   S/T content:   4                         Score: −1.76       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 35 QRV|EG                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 8.0%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: ERLW                 none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         47.8%: mitochondrial           26.1%: cytoplasmic            8.7%: Golgi            4.3%: vacuolar            4.3%: vesicles of secretory system            4.3%: nuclear            4.3%: endoplasmic reticulum                 &gt;&gt; prediction for CG52534-06 is mit (k = 23)                  
 
      A search of the NOV17a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 17D.  
               TABLE 17D                          Geneseq Results for NOV17a                                         NOV17a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               AAY96211   Transferrin receptor-like (TfR2) protein -   1 . . . 372   369/372 (99%)   0.0             Homo sapiens , 801 aa.   1 . . . 372   370/372 (99%)           [WO200027874-A2, 18-MAY-2000]       ABB11600   Human transferrin receptor homologue,   1 . . . 372   366/372 (98%)   0.0           SEQ ID NO: 1970 -  Homo sapiens , 802   1 . . . 372   367/372 (98%)           aa. [WO200157188-A2, 09-AUG-2001]       AAB93873   Human protein sequence SEQ ID   1 . . . 158   158/158 (100%)   9e−90           NO: 13773 -  Homo sapiens , 158 aa.   1 . . . 158   158/158 (100%)           [EP1074617-A2, 07-FEB-2001]       ABP56714   Human CD71 protein SEQ ID NO: 28 -   84 . . . 371    112/299 (37%)   1e−42             Homo sapiens , 760 aa.   68 . . . 349    159/299 (52%)           [WO2002100336-A2, 19-DEC-2002]       ABU04022   Human expressed protein tag (EPT)   84 . . . 371    112/299 (37%)   1e−42           #688 -  Homo sapiens , 760 aa.   68 . . . 349    159/299 (52%)           [WO200278524-A2, 10-OCT-2002]                  
 
      In a BLAST search of public sequence databases, the NOV17a protein was found to have homology to the proteins shown in the BLASTP data in Table 17E.  
               TABLE 17E                          Public BLASTP Results for NOV17a                                         NOV17a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q9UP52   Transferrin receptor protein 2 (TfR2) -    1 . . . 372   369/372 (99%)   0.0             Homo sapiens  (Human), 801 aa.    1 . . . 372   370/372 (99%)       Q9JKX3   Transferrin receptor protein 2 (TfR2) -    1 . . . 371   293/371 (78%)    e−166             Mus musculus  (Mouse), 798 aa.    1 . . . 366   313/371 (83%)       Q07891   Transferrin receptor protein 1 (TfR1)   87 . . . 371   112/296 (37%)   6e−45           (TR) (TfR) (Trfr) -  Cricetulus griseus     71 . . . 346   160/296 (53%)           (Chinese hamster), 757 aa.       P02786   Transferrin receptor protein 1 (TfR1)   84 . . . 371   112/299 (37%)   3e−42           (TR) (TfR) (Trfr) (CD71 antigen) (T9)   68 . . . 349   159/299 (52%)           (p90) -  Homo sapiens  (Human), 760 aa.       Q8C872   Transferrin receptor -  Mus musculus     84 . . . 367   107/292 (36%)   4e−42           (Mouse), 515 aa.   68 . . . 347   152/292 (51%)                  
 
      PFam analysis predicts that the NOV17a protein contains the domains shown in the Table 17F.  
      Table 17F. Domain Analysis of NOV17a  
               TABLE 17F                          Domain Analysis of NOV17a                                             Identities/                       Similarities           Pfam   NOV17a   for the   Expect           Domain   Match Region   Matched Region   Value                       PA   236 . . . 335   36/112 (32%)   8.7e−14                   70/112 (62%)           TFR_dimer   247 . . . 416   34/188 (18%)   0.45                   121/188 (64%)                       
 
     Example 18  
      The NOV18 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 18A.  
               TABLE 18A                       NOV18 Sequence Analysis                                                NOV18a, CG52979-03   SEQ ID NO: 469   458 bp                             DNA Sequence   ORF Start: ATG at 61   Stop: TAG at 343                             TCTTCATTCTTTCCGCCATCTTGATTCTTTCTCACTGACCAAGACTCAGCCGTGGGAAATATGAGTGA           GCTTGTAAGAACAACATCCCAATCCTCAGAAAGAGGAAATGACCAAGAGTCTTCCCAGCCAGTTGGAT       CTGTGATTGTCCAGGAGCCCACTGAGGAAAAGCGTCAAGAAGAGGAACCACCAACTGATAATCAGGGG       TGATGTCAGGGAGGGTATTATGCCCACTTTTGATCTCACTAAAGTGCTGGAAGCAGGTGATGCGCAAC       CATAGGTTTCAAGCAAGACAAATGAAGACTGAAACCAAGAACGTTATTCTTAATCTGGAAATTTGACT       GATAATATTCTCTTAATAAAGTTTTAAGTTTTCTGCAAAGAATCCTTAAA                                         NOV18a, CG52979-03                                     Protein Sequence   SEQ ID NO: 470   94 aa   MW at 10341.1kD                             MSELVRTTSQSSERGNDQESSQPVGSVIVQEPTEEKRQEEEPPTDNQGPDMEAFQQELALLKIEDEPG           DGPDVREGIMPTFDLTKVLEAGDAQP                                             NOV18b, CG52979-01   SEQ ID NO: 471   458 bp                             DNA Sequence   ORF Start: ATG at 61   ORF Stop: TAG at 343                             TCTTCATTCTTTCCGCCATCTTGATTCTTTCTCACTGACCAAAGACTCAGCCGTGGGAAAATATGTGA           GCTTGTAAGAGCAAGATCCCAATCCTCAGAAAGAGGAAATGACCAAGAGTCTTCCCAGCCGGTTGGAT       CTGTGATTGTCCAGGAGCCCACTGAGGAAAAACGTCAAGAAGAGGAACCACCAACTGATAATCAGGGG       CCTGACATGGAAGCTTTTCAACAGGAACTGGCTCTGCTTAAGATAGAGGATGAGCCTGGAGATGGTCC       TGATGTCAGGGAGGGTATTATGCCCACTTTTGATCTCACTAAAGTGCTGGAAGCAGGTGATGCGCAAC       CATAGGTTTCAAGCAAGACAAATGAAGACTGAAACCAAGAACGTTATTCTTAATCTGGAAATTTGACT       GATAATATTCTCTTAATAAAGTTTTAAGTTTTCTGCAAAGAATCCTTAAA                                         NOV18b, CG52979-01                                     Protein Sequence   SEQ ID NO: 472   94 aa   MW at 10366.1kD                             MSELVRTTSQSSERGNDQESSQPVGSVIVQEPTEEKRQEEEPPTDNQGPDMEAFQQELALLKIEDEPG           DGPDVREGIMPTFDLTKVLEAGDAQP                                             NOV18c, CG52979-02   SEQ ID NO: 473   336 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: at 112                             TGGTTGCGCATCACCTGCTTCCAGCACTTTAGTGAGATCAAAAGTGGGCATAATACCCTCCCTGACAT           CAGGACCATCTCCAGGCTCATCCTCTATCTTAAGCAGAGCCAGTTCCTGTTGAAAAGCTTCCATGTCA       GGCCCTTGAAAAGCAGGCACTGCTTGATTTTCAATCTCCCCACTAGGTGCAATACCCTGATTATCAGT       TGGTGGTTCCTCTTCTTGACGTTTTTCCTCAGTGGGCTCCTGGACAATCACAGATCCAACCGGCTGGG       AAGACTCTTGGTCATTTCCTCTTTCTGAGGATTGGGATCTTGCTCTTACAAGCTCACTCATGGT                                         NOV18c, CG52979-02                                     Protein Sequence   SEQ ID NO: 474   37 aa   MW at 4444.1kD                             WLRITCFQHFSEIKSGHNTLPDIRTISRLILYLKQSQ                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 18B.  
               TABLE 18B                       Comparison of the NOV18 protein sequences.                                            NOV18a   MSELVRTTSQSSERGNDQESSQPVGSVIVQEPTEEKRQEEEPPTDNQGPDMEAFQQELAL                   NOV18b   MSELVRARSQSSERGNDQESSQPVGSVIVQEPTEEKRQEEEPPTDNQGPDMEAFQQELAL               NOV18c   ----------------------------WLRITCFQHFSEIKSGHNTLPDIRTISRLILY               NOV18a   LKIEDEPGDGPDVREGIMPTFDLTKVLEAGDAQP               NOV18b   LKIEDEPGDGPDVREGIMPTFDLTKVLEAGDAQP               NOV18c   LKQSQ-----------------------------               NOV18a (SEQ ID NO: 470)               NOV18b (SEQ ID NO: 472)               NOV18c (SEQ ID NO: 474)                  
 
      Further analysis of the NOV18a protein yielded the following properties shown in Table 18C.  
               TABLE 18C                       Protein Sequence Properties NOV18a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 6; pos. chg 1; neg. chg 1           H-region:   length 6; peak value −10.69           PSG score:   −15.09                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −14.03           possible cleavage site: between 14 and 15                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 0           number of TMS(s) . . . fixed                             PERIPHERAL   Likelihood = 10.87 (at 76)                         ALOM score: 10.87 (number of TMSs: 0)       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:    1   Hyd Moment(75):   5.19           Hyd Moment(95):   12.09   G content:   0           D/E content:    2   S/T content:   6                         Score: −3.75       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 7.4%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 94.1       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         78.3%: nuclear           21.7%: mitochondrial                 &gt;&gt; prediction for CG52979-03 is nuc (k = 23)                  
 
      A search of the NOV18a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 18D.  
               TABLE 18D                          Geneseq Results for NOV18a                                         NOV18a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               AAE08580   Human NOV1 protein -  Homo sapiens ,   1 . . . 94   92/94 (97%)   1e−47           94 aa. [WO200161009-A2, 23-AUG-   1 . . . 94   92/94 (97%)           2001]       AAE08593   Protein encoded by pCR2.1-83350421-   1 . . . 94   92/111 (82%)   2e−44           S747-3A insert -  Homo sapiens , 111 aa.    1 . . . 111   92/111 (82%)           [WO200161009-A2, 23-AUG-2001]       AAE08582   Human NOV3 protein -  Homo sapiens ,   1 . . . 94   92/111 (82%)   2e−44           111 aa. [WO200161009-A2, 23-AUG-    1 . . . 111   92/111 (82%)           2001]       ABJ19255   Human cancer/testis antigen - SEQ ID   1 . . . 94   92/111 (82%)   4e−44           No 37 -  Homo sapiens , 111 aa.    1 . . . 111   92/111 (82%)           [WO200278526-A2, 10-OCT-2002]       AAE08581   Human NOV2 protein -  Homo sapiens ,   1 . . . 94   92/111 (82%)   4e−44           111 aa. [WO200161009-A2, 23-AUG-    1 . . . 111   92/111 (82%)           2001]                  
 
      In a BLAST search of public sequence databases, the NOV18a protein was found to have homology to the proteins shown in the BLASTP data in Table 18E.  
               TABLE 18E                          Public BLASTP Results for NOV18a                                         NOV18a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q8WWL9   Page-5 protein -  Homo sapiens     1 . . . 93   80/110 (72%)   4e−35           (Human), 130 aa.   21 . . . 129   84/110 (75%)       Q96GU1   Hypothetical protein -  Homo sapiens     1 . . . 93   80/110 (72%)   4e−35           (Human), 110 aa.    1 . . . 109   84/110 (75%)       O60829   G antigen family C 1 protein (Prostate-   6 . . . 94   39/104 (37%)   1e−06           associated gene protein 4) (PAGE-4)    4 . . . 102   47/104 (44%)           (PAGE-1) (JM27) (GAGE-9) -  Homo               sapiens  (Human), 102 aa.       Q8WTP9   Placenta-specific gene 6 protein (XAGE-   31 . . . 94    31/82 (37%)   4e−06           3 protein) (pp9012) -  Homo sapiens     28 . . . 109   43/82 (51%)           (Human), 111 aa.       Q8WWM1   XAGE-5 protein -  Homo sapiens     21 . . . 94    32/92 (34%)   7e−06           (Human), 108 aa.   17 . . . 106   49/92 (52%)                  
 
      PFam analysis predicts that the NOV18a protein contains the domains shown in the Table 18F.  
               TABLE 18F                       Domain Analysis of NOV18a                                                Pfam   NOV18a Match Region   Identities/   Expect       Domain       Similarities for   Value               the Matched               Region                  
 
     Example 19.  
      The NOV19 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 19A.  
               TABLE 19A                          NOV19 Sequence Analysis                                     NOV19a, CG52988-02   SEQ ID NO: 475   501 bp           DNA Sequence   ORF Start: ATG at 25   ORF Stop: TAG at 358                     GGGAAGAGACCATGTGTGGGAAATATGAGTGAGCTTGTAAGAACAAGATCCCAATCCTCAGAAAGAGG           AAATGACCAAGAGTCTTCCCAGCCGGTTGGATCTGTGATTGTCCAGGAGCCCACTGAGGAAAAACGTC       AAGAAGAGGAACCACCAACTGATAATCAGGGTATTGCACCTAGTGGGGAGATTGAAAATCAAGCAGTG       CCTGCTTTTCAAGGGCCTGACATGGAAGCTTTTCAACAGGAACTGGCTCTGCTTAAGATAGAGGATGA       GCCTGGAGATGGTCCTGATGTCAGGGAGGGTATTATGCCCACTTTTGATCTCACTAAAGTGCTGGAAG       CAGGTGATGCGCAACCATAGGTTTCAAGCAAGACAAATGAAGACTGAAACCAAGAACGTTATTCTTAA       TCTGGAAATTTGACTGATAATATTCTCTTAATAAAGTTTTAAGTTTTCTGCAAAGAATCCTCAAAAAA       AAAAAAAAAAAAAAAAAAAAAGGG                                 NOV19a, CG52988-02   SEQ ID NO: 476   111 aa   MW at 12106.0kD           Protein Sequence                     MSELVRTRSQSSERGNDQESSQPVGSVIVQEPTEEKRQEEEPPTDNQGIAPSGEIENQAVPAFQGPDM           EAFQQELALLKIEDEPGDGPDVREGIMPTFDLTKVLEAGDAQP                             NOV19b, CG52988-03   SEQ ID NO: 477   374 bp           DNA Sequence   ORF Start: ATG at 23   ORF Stop: TAG at 356                     GAAGAGACCATGTGTGGGAAATATGAGTGAGCTTGTAAGAGCAAGATCCCAATCCTCAGAAAGAGGAA           ATGACCAAGAGTCTTCCCAGCCGGTTGGATCTGTGATTGTCCAGGAGCCCACTGAGGAAAACGTCA       GAAGAGGAACCACCAACTGATAATCAGGGTATTGCACCTAGTGGGGAGATTGAAAATCAAGCAGTGCC       TGCTTTTCAAGGGCCTGACATGGAAGCTTTTCAACAGGAACTGGCTCTGCTTAAGATAGAGGATGAGC       CTGGAGATGGTCCTGATGTCAGGGAGGGTATTATGCCCACTTTTGATCTCACTAA~GTGCTGGAAGCA       IGGTGATGCGCAACCATAQGTTTCAAGCAAGACAA                                 NOV19b, CG52988-03   SEQ ID NO: 478   111 aa   MW at 12076 0kD           Protein Sequence                     MSELVRARSQSSERGNDQESSQPVGSVIVQEPTEEKRQEEEPPTDNQGIAPSGEIENQAVPAFQGPDM           EAFQQELALLKIEDEPGDGPDVREGIMPTEDLTKVLEAGDAQP                             NOV19c, CG52988-04   SEQ ID NO: 479   1337 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAG at 334                     ATGAGTGAGCATGTGAGAACAACATCCCAATCCTCAGAAGAGGAAATGACCAAGAGTCTTCCCAGCC           AGTTGGATCTGTGATTGTCCAGGAGCCCACTGAGGAAAAACGTCAAGAAGAGGAACCACCAACTGATA       ATCAGGGTATTGCACCTAGTGGGGAGATCGAAAATGAAGGAGCACCTGCCGTTCAAGGGCCTGACATG       GAAGCTTTTCAAACAGGAACTGGCTCTGCTTAAGATAGAGGATGAGCCTGGAGATGGTCCTGATGTCAG       GGAGGGGATTATGCCCACTTTTGATCTCACTAAAGTGCTGGAAGCAGGTGATGCGCAACCATAGT                                 NOV19c, CG52988-04   SEQ ID NO: 480   111 a   MW at 11985.8kD           Protein Sequence                     MSEAAAATTSQSSERGNDQESSQPVGSVIVQEPTEEKRQEEEPPTDNQGIAPSGEIENEGAPAVQGPDM           EAFQQELALLKIEDEPGDGPDVREGIMPTFDLTKVLEAGDAQP                             NOV19d, CG52988-06   SEQ ID NO: 481   344 bp           DNA Sequence   ORF Start: ATG at 9   ORF Stop: TAG at 342                     GTGGAATATGATTGAGCATGTGAGAACAATATCCCAATCCTCAGAAGAGGAAATGACCAAAGAGTCT           AACTGATAATCAGGGTATTGCACCTAGTGGGGAGATCGAAAATGAAGGAGCACCTGCCGTTCAAGGGC       CTGACATGGAAGCTTTTCAACAGGAACTGGCTCTGCTTAAGATAGAGGATGAGCCTGGAGATGGTCCT       GATGTCAGGGAGGGGATTATGCCCACTTTTGATCTCACTAGAGTGCTGGAAGCAGGTGATGCGCAACC       ATAG                                 NOV19d, CG52988-06   SEQ ID NO: 482   111 aa   MW at 12061 .0kD           Protein Sequence                     MIEHVRTSQSSERGNDQESSHPVGSVIVQEPTEEKRQEEEPPTDNQGIAPSGEIENEGAPAVQGPDM           EAFQQELALLKIEDEPGDGPDVREGIMPTFDLTRVLEAGDAQP                             lNOV19e, CG52988-07   SEQ ID NO: 483   1343 bp           DNA Sequence   ORF Start: ATG at 8   ORF Stop: TAG at 341                     GGGAAATATGAGTGAGCATGTGAGAACAAGATCCCAATCCTCAGAAAGAGGAAATGACCAAGAGTCTT           ACTGATAATCAGGGTATTGCGCCTAGTGGGGAGATCGAAAATGAAGGAGCACCTGCCGTTCAAGGGCC       TGACATGGAAGCTTTTCAACAGGAACTGGCTCTGCTTAAGATAGAGGATGAGCCTGGAGATGGTCCTG       ATGTCAGGGAGGGGATTATGCCCACTTTTGATCTCACTAAAGTGCTGGAAGCAGGTGATGCGCAACCA       TAG                                 NOV19e, CG52988-07   SEQ ID NO: 484   111 aa   MW at 12040.9kD           Protein Sequence                     MSEHVRTRSQSSERGNDQESSQPVGSVTVQEPTEEKRQEEEPTDNQGIAGEIENEGAPAVQGPDM           EAFQQELALLKIEDEPGDGPDVREGIMPTFDLTKVLEAGDAQ                             NOV19f, CG52988-01   SEQ ID NO: 485   475 bp           DNA Sequence   ORF Start: ATG at 25   ORF Stop: TAG at 358                     AAATGACCAAGAGTCTTCCCAGCCAGTTGGATCTGTGATTGTCCAGGAGCCCACTGAGGAAAAAAACGTC           AAGAAGAGGAACCACCAACTGATAATCAGGGTATTGCACCTAGTGGGGAGATCGAATGAAAGGAGCA       CCTGCCGTTCAAGGGCCTGACATGGAAGCTTTTCACAGGAAACTGGCTCTGCTTAAAGATAGAGGATGA       GCCTGGAGATGGTCCTGATGTCAGGGAGGGGATTATGCCCACTTTTGATCTCACTAAAGTGCTGGAAG       CAGGTGATGCGCAACCATAGGTTTCAAGCAGACATGAAGACTGAACCAGAACGTTATTCTTA14       TCTGGAAATTTGACTGATAATATTCTCTTAATAGTTTTAGTTTTCTGCAGA                                 NOV19f,CG52988-01   SEQ ID NO: 486   111 aa   MW at 12040.9kD           Protein Sequence                     MSEHVRTRSQSSERGNDQESSQPVGSVIVQEPTEEKRQEEEPPTDNQGIAPSGEIENEGAPAVQGPDM           IEAFQQELALLKIEDEPGDGPDVREGIMPTFDLTKvLEAGDAQP                             NOV19g, CG52988-05   SEQ ID NO: 487   1344 bp           DNA Sequence   ORF Start: ATG at 9   ORF Stop: TAG at 342                     TGGGAAATATGAGTGAGCATGTGAGAACAACATCCCAATCCTCAGAAAGAGGAAATGACCAAGAGTCT           CTGACATGGAAGCTTTTCAACAGGAACTGGCTCTGCTTAAGATAGAGGATGAGCCTGGAGATGGTCCT       GATGTCAGGGAGGGGATTATGCCCACTTTTGATCTCACTAAAGTGCTGGAAGCAGGTGATGCGCAACC       ATAG                                 NOV19g, CG52988-05   SEQ ID NO: 488   111 aaa   MW at 12027.9kD           Protein Sequence                     MSEHVRTTSQSSERGNDQESSQPVVSVIVQEPTEEKRQEEEPPTDNQGIApSGEIENEGAPAVQGPDM           EAFQQELALLKIEDEPGDGPDVREGIMPTFDLTKVLEAGDAQP                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 19B.  
               TABLE 19B                       Comparison of the NOV19 protein sequences.                                            NOV19a   MSELVRTRSQSSERGNDQESSQPVGSVIVQEPTEEKRQEEEPPTDNQGIAPSGEIENQAV           NOV19b   MSELVRARSQSSERGNDQESSQPVGSVIVQEPTEEKRQEEEPPTDNQGIAPSGEIENQAV       NOV19c   MSEHVRTTSQSSERGNDQESSQPVGSVIVQEPTEEKRQEEEPPTDNQGIAPSGEIENEGA       NOV19d   MIEHVRTISQSSERGNDQESSHPVGSVIVQEPTEEKRQEEEPPTDNQGIAPSGEIENEGA       NOV19e   MSEHVRTRSQSSERGNDQESSQPVGSVIVQEPTEEKRQEEEPPTDNQGIAPSGEIENEGA       NOV19f   MSEHVRTRSQSSERGNDQESSQPVGSVIVQEPTEEKRQEEEPPTDNQGIAPSGEIENEGA       NOV19g   MSEHVRTTSQSSERGNDQESSQPVVSVIVQEPTEEKRQEEEPPTDNQGIAPSGEIENEGA               NOV19a   PAFQGPDMEAFQQELALLKIEDEPGDGPDVREGIMPTFDLTKVLEAGDAQP       NOV19b   PAFQGPDMEAFQQELALLKIEDEPGDGPDVREGIMPTFDLTKVLEAGDAQP       NOV19c   PAVQGPDMEAFQQELALLKIEDEPGDGPDVREGIMPTFDLTKVLEAGDAQP       NOV19d   PAVQGPDMEAFQQELALLKIEDEPGDGPDVREGIMPTFDLTRVLEAGDAQP       NOV19e   PAVQGPDMEAFQQELALLKIEDEPGDGPDVREGIMPTFDLTKVLEAGDAQP       NOV19f   PAVQGPDMEAFQQELALLKIEDEPGDGPDVREGIMPTFDLTKVLEAGDAQP       NOV19g   PAVQGPDMEAFQQELALLKIEDEPGDGPDVREGIMPTFDLTKVLEAGDAQP               NOV19a   (SEQ ID NO: 476)       NOV19b   (SEQ ID NO: 478)       NOV19c   (SEQ ID NO: 480)       NOV19d   (SEQ ID NO: 482)       NOV19e   (SEQ ID NO: 484)       NOV19f   (SEQ ID NO: 486)       NOV19g   (SEQ ID NO: 488)                  
 
      Further analysis of the NOV19a protein yielded the following properties shown in Table 19C.  
               TABLE 19C                       Protein Sequence Properties NOV19a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 8; pos. chg 2; neg. chg 1           H-region:   length 4; peak value −13.93           PSG score:   −18.33                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −15.73           possible cleavage site: between 14 and 15                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 0           number of TMS(s) . . . fixed                             PERIPHERAL   Likelihood = 10.87 (at 93)                         ALOM score: 10.87 (number of TMSs: 0)       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   2   Hyd Moment(75):   8.54           Hyd Moment(95):   6.16   G content:   0           D/E content:   2   S/T content:   5                         Score: −3.37       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 7.2%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         69.6%: nuclear           26.1%: mitochondrial            4.3%: cytoplasmic                 &gt;&gt; prediction for CG52988-02 is nuc (k = 23)                  
 
      A search of the NOV19a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 19D.  
               TABLE 19D                          Geneseq Results for NOV19a                                         NOV19a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               AAE08593   Protein encoded by pCR2.1-83350421-   1 . . . 111   110/111 (99%)   3e−58           S747-3A insert -  Homo sapiens , 111   1 . . . 111   110/111 (99%)           aa. [WO200161009-A2, 23-AUG-2001]       AAE08582   Human NOV3 protein -  Homo sapiens ,   1 . . . 111   110/111 (99%)   3e−58           111 aa. [WO200161009-A2, 23-AUG-   1 . . . 111   110/111 (99%)           2001]       ABJ19255   Human cancer/testis antigen - SEQ ID   1 . . . 111   106/111 (95%)   6e−56           No 37 -  Homo sapiens , 111 aa.   1 . . . 111   107/111 (95%)           [WO200278526-A2, 10-OCT-2002]       AAE08581   Human NOV2 protein -  Homo sapiens ,   1 . . . 111   106/111 (95%)   6e−56           111 aa. [WO200161009-A2, 23-AUG-   1 . . . 111   107/111 (95%)           2001]       ABJ19247   Human cancer/testis antigen - SEQ ID   1 . . . 110   93/110 (84%)   7e−47           No 21 -  Homo sapiens , 110 aa.   1 . . . 109   99/110 (89%)           [WO200278526-A2, 10-OCT-2002]                  
 
      In a BLAST search of public sequence databases, the NOV 19 a protein was found to have homology to the proteins shown in the BLASTP data in Table  19 E.  
               TABLE 19E                          Public BLASTP Results for NOV19a                                         NOV19a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             Q8WWL9   Page-5 protein -  Homo sapiens      1 . . . 110   93/110   (84%)   2e−46           (Human), 130 aa.   21 . . . 129   99/110   (89%)       Q96GU1   Hypothetical protein -  Homo sapiens      1 . . . 110   93/110   (84%)   2e−46           (Human), 110 aa.    1 . . . 109   99/110   (89%)       O60829   G antigen family C 1 protein (Prostate-    6 . . . 111   45/106   (42%)   5e−11           associated gene protein 4) (PAGE-4)    4 . . . 102   53/106   (49%)           (PAGE-1) (JM27) (GAGE-9) -  Homo               sapiens  (Human), 102 aa.       Q8WTP9   Placenta-specific gene 6 protein (XAGE-    8 . . . 111   42/108   (38%)   3e−10           3 protein) (pp9012) -  Homo sapiens      4 . . . 109   62/108   (56%)           (Human), 111 aa.       Q8WWM1   XAGE-5 protein -  Homo sapiens     21 . . . 111   36/92   (39%)   5e−09           (Human), 108 aa.   17 . . . 106   55/92   (59%)                  
 
      PFam analysis predicts that the NOV19a protein contains the domains shown in the Table 19F.  
               TABLE 19F                       Domain Analysis of NOV19a                                                        Pfam   NOV19a   Identities/   Expect           Domain   Match Region   Similarities   Value                   for the                   Matched Region                      
 
     Example 20  
      The NOV20 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 20A.  
               TABLE 20A                       NOV20 Sequence Analysis                                                NOV20a, CG53449-04   SEQ ID NO: 489   2165 bp                             DNA Sequence   ORF Start: ATG at 153   ORF Stop: TGA at 1194                             AGAACAGCGCAGTTTGCCCTCCGCTCACGCAGAGCCTCTCCGTGGCCTCCGCACCTTGAGCATTAGGC           CAGTTCTCCTCTTCTCTCTAATCCATCCGTCACCTCTCCTGTCATCCGTTTCCATGCCGTGAGGTCCA       TTCACAGAACACATCCATGGCTCTCATGCTCAGTTTGGTTCTGAGTCTCCTCAAGCTGGGATCAGGGC       TTCCTGTCTCCTAAGACCAATGCAGAGGCCATGGAAGTGCGGTTCTTCAGGGGCCAGTTCTCTAGCGT       GGTCCACCTCTACAGGGACGGGAAGGACCAGCCATTTATGCAGATGCCACAGTATCAAGGCAGGACAA       AACTGGTGAAGGATTCTATTGCGGAGGGGCGCATCTCTCTGAGGCTGGAAAACATTACTGTGTTGGAT       GCTGGCCTCTATGGGTGCAGGATTAGTTCCCAGTCTTACTACCAGAAGGCCATCTGGGAGCTACAGGT       GTCAGCACTGGGCTCAGTTCCTCTCATTTCCATCACGGGATATGTTGATAGAGACATCCAGCTACTCT       GTCAGTCCTCGGGCTGGTTCCCCCGGCCCACAGCGAAGTGGAAAGGTCCACAAGGACAGGATTTGTCC       ACAGACTCCAGGACAAACAGAGACATGCATGGCCTGTTTGATGTGGAGATCTCTCTGACCGTCCAAGA       GAACGCCGGGAGCATATCCTGTTCCATGCGGCATGCTCATCTGAGCCGAGAGGTGGAATCCAGGGTAC       AGATAGGAGATACCTTTTTCGAGCCTATATCGTGGCACCTGGCTACCAAAGTACTGGGAATACTCTGC       TGTGGCCTATTTTTTGGCATTGTTGGACTGAAGATTTTCTTCTCCAAATTCCAGTGTAAGCGAGAGAG       AGAAGCATGGGCCGGTGCCTTATTCATGGTTCCAGCAGGGACAGGATCAGAGATGCTCCCACATCCAG       CTGCTTCTCTTCTTCTAGTCCTAGCCTCCAGGGGCCCAGGCCCAAAAAAGGAAAATCCAGGCGGAACT       GGACTGGAGAAGAAAGCACGGACAGGCAGAATTGAGAGACGCCCGGAAACACGCAGTGGAGGTGACTC       TGGATCCAGAGACGGCTCACCCGAAGCTCTGCGTTTCTGATCTGAAAACTGTAACCCATAGAAAAGCT       CCCCAGGAGGTGCCTCACTCTGAGAAGAGATTTACAAGGAAGAGTGTGGTGGCTTCTCAGAGTTTCCA       AGCAGGGAAACATTACTGGGAGGTGGACGGAGGACACAATAAAAGGTGGCGCGTGGGAGTGTGCCGGG       AATGGAGAACATTTGTATTTCACATTAAATCCCCGTTTTATCAGCGTCTTCCCCAGGACCCCACCTAC       AAAAATAGGGGTCTTCCTGGACTATGAGTGTGGGACCATCTCCTTCTTCAACATAAATGACCAGTCCC       TTATTTATACCCTGACATGTCGGTTTGAAGGCTTATTGAGGCCCTACATTGAGTATCCGTCCTATAAT       GAGCAAAATGGAACTCCCATAGTCATCTGCCCAGTCACCCAGGAATCAGAGAAAGAGGCCTCTTGGCA       AAGGGCCTCTGCAATCCCAGAGACAAGCAACAGTGAGTCCTCCTCACAGGCAACCACGCCCTTCCTCC       CCAGGGGTGAAATGTAGGATGAATCACATCCCACATTCTTCTTTAGGGATATTAAGGTCTCTCTCCCA       GATCCAAAGTCCCGCAGCAGCCGGCCAAGGTGGCTTCCAGATGAAGGGGGACTGGCCTGTCCACATGG       CTCCATCTGGCTAAGTGATCTTGAAATACCACCTCTCAGGTGAAGAACCGTCAGGAATTCCCATCTCA       TATCCTAATGGTTTGTTCATTATATTACACTTTCAGTAAAAAAAAAAAAAAAAAAA                                         NOV20a, CG53449-04                                     Protein Sequence   SEQ ID NO: 490   347 aa   MW at 38208.5kD                             MALMLSLVLSLLKLGSGQWQVFGPDKPVQALVGEDAAFSCFLSPKTNAEAMEVRFFRGQFSSVVHLYR           DGKDQPFMQMPQYQGRTKLVKDSIAEGRISLRLENITVLDAGLYGCRISSQSYYQKAIWELQVSALGS       VPLISITGYVDPDIQLLCQSSGWFPRPTAKWKGPQGQDLSTDSRTNRDMHGLFDVEISLTVQENAGSI       SCSMRHAHLSREVESRVQIGDTFFEPISWHLATKVLGILCCGLFFGIVGLKIFFSKFQCKREREAWAG       ALFMVPAGTGSEMLPHPAASLLLVLASRGPGPKKENPGGTGLEKKARTGRIERRPETRSGGDSGSRDG       SPEALRF                                             NOV20b, CG53449-03   SEQ ID NO: 491   1969 bp                             DNA Sequence   ORF Start: ATG at 95   ORF Stop: TAG at 1595                             AGCATTAGGCCAGTTCTCCTCTTCTCTCTAATCCATCCGTCACCTCTCCTGTCATCCGTTTCCATGCC           GTGAGGTCCATTCACAGAACACATCCATGGCTCTCATGCTCAGTTTGGTTCTGAGTCTCCTCAAGCTG       GGATCAGGGCAGTGGCAGGTGTTTGGGCCAGACAAGCCTGTCCAGGCCTTGGTGGGGGAGGACGCAGC       ATTCTCCTGTTTCCTGTCTCCTAAGACCAATGCAGAGGCCATGGAAGTGCGGTTCTTCAGGGGCCAGT       TCTCTAGCGTGGTCCACCTCTACAGGGACGGGAAGGACCAGCCATTTATGCAGATGCCACAGTATCAA       GGCAGGACAAAACTGGTGAAGGATTCTATTGCGGAGGGGCGCATCTCTCTGAGGCTGGAAAACATTAC       TGTGTTGGATGCTGGCCTCTATGGGTGCAGGATTAGTTCCCAGTCTTACTACCAGAAGGCCATCTGGG       AGCTACAGGTGTCAGCACTGGGCTCAGTTCCTCTCATTTCCATCACGGGATATGTTGATAGAGACATC       CAGCTACTCTGTCAGTCCTCGGGCTGGTTCCCCCGGCCCACAGCGAAGTGGAAAGGTCCACAAGGACA       GGATTTGTCCACAGACTCCAGGACAAACAGAGACATGCATGGCCTGTTTGATGTGGAGATCTCTCTGA       CCGTCCAAGAGAACGCCGGGAGCATATCCTGTTCCATGCGGCATGCTCATCTGAGCCGAGAGGTGGAA       TCCAGGGTACAGATAGGAGATACCTTTTTCGAGCCTATATCGTGGCACCTGGCTACCAAAGTACTGGG       AATACTCTGCTGTGGCCTATTTTTTGGCATTGTTGGACTGAAGATTTTCTTCTCCAAATTCCAGTGGA       AAATCCAGGCGGAACTGGACTGGAGAAGAAAGCACGGACAGGCAGAATTGAGAGACGCCCGGAAACAC       GCAGTGGAGGTGACTCTGGATCCAGAGACGGCTCACCCGAAGCTCTGCGTTTCTGATCTGAAPACTGT       AACCCATAGAAAAGCTCCCCAGGAGGTGCCTCACTCTGAGAAGAGATTTACAAGGAAGAGTGTGGTGG       CTTCTCAGAGTTTCCAAGCAGGGAAACATTACTGGGAGGTGGACGGAGGACACAATAAAAGGTGGCGC       GTGGGAGTGTGCCGGGATGATGTGGACAGGAGGAAGGAGTACGTGACTTTGTCTCCCGATCATGGGTA       CTGGGTCCTCAGACTGAATGGAGAACATTTGTATTTCACATTAAATCCCCGTTTTATCAGCGTCTTCC       CCAGGACCCCACCTACAAAAATAGGGGTCTTCCTGGACTATGAGTGTGGGACCATCTCCTTCTTCAAC       ATAAATGACCAGTCCCTTATTTATACCCTGACATGTCGGTTTGAAGGCTTATTGAGGCCCTACATTGA       GTATCCGTCCTATAATGAGCAAAATGGAACTCCCATAGTCATCTGCCCAGTCACCCAGGAATCAGAGA       ACCACGCCCTTCCTCCCCAGGGGTGAAATGTAGGATGAATCACATCCCACATTCTTCTTTAGGGATAT       TAAGGTCTCTCTCCCAGATCCAAAGTCCCGCAGCAGCCGGCCAAGGTGGCTTCCAGATGAAGGGGGAC       TGGCCTGTCCACATGGGAGTCAGGTGTCATGGCTGCCCTGAGCTGGGAGGGAAGAAGGCTGACATTAC       ATTTAGTTTGCTCTCACTCCATCTGGCTAAGTGATCTTGAAATACCACCTCTCAGGTGAAGAACCGTC       AGGAATTCCCATCTCACAGGCTGTGGTGTAGATTAAGTAGACAAGGAATGTGAATAATGCTTAGATCT       TATTGATGACAGAGTGTATCCTAATGGTTTGTTCATTATATTACACTTTCAGTAAAAAAAAAAAA                                         NOV20b, CG53449-03                                     Protein Sequence   SEQ ID NO: 492   500 aa   MW at 56747.1kD                             MALMLSLVLSLLKLGSGQWQVFGPDKPVQALVGEDAAFSCFLSPKTNAEAMEVRFFRGQFSSVVHLYR           DGKDQPFMQMPQYQGRTKLVKDSIAEGRISLRLENITVLDAGLYGCRISSQSYYQKAIWELQVSALGS       VPLISITGYVDRDIQLLCQSSGWFPRPTAKWKGPQGQDLSTDSRTNRDMHGLFDVEISLTVQENAGSI       SCSMRHAHLSREVESRVQIGDTFFEPISWHLATKVLGILCCGLFFGIVGLKIFFSKFQWKIQAELDWR       HYWEVDGGHNKRWRVGVCRDDVDRRKEYVTLSPDHGYWVLRLNGEHLYFTLNPRFISVFPRTPPTKIG       VFLDYECGTISFFNINDQSLIYTLTCRFEGLLRPYIEYPSYNEQNGTPIVICPVTQESEKEASWQRAS       AIPETSNSESSSQATTPFLPRGEM                                             NOV20c, CG53449-01   SEQ ID NO: 493   252 bp                             DNA Sequence   ORF Start: ATG at 1   ORF Stop: end of sequence                             ATGAACCCGGTACCTCAGATGGAAATGCAGAAATCACCCATGTTCTGCGTCGCTCACTCTGGGAGCTG           TAGACCGGAGCTGTTCCTATTCGGCCATCTTGGCTCCTCCCCCTCACTACAAAGGGTTTTGATGATTT       ATCTTTTGTATGTCTTCCCACAGGGCAGTGGCAGGTGTTTGGGCCAGACAAGCCTGTCCAGGCCTTGG       TGGGGGAGGACGCAGCATTCTCCTGTTTCCTGTCTCCTAAAACCAATG                                         NOV20c, CG53449-01                                     Protein Sequence   SEQ ID NO: 494   84 aa   MW at 9453.1kD                             MNPVPQMEMQKSPMFCVAHSGSCRPELFLFGHLGSSPSLQRVLMYLLYVFPQGSGRCLGQTSLSRPW           WGRTQHSPVSCLLKPM                                             NOV20d, CG53449-02   SEQ ID NO: 495   1495 bp                             DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 1492                             ATGAACCCGGTACCTCAGATGGAAATGCAGAAATCACCCATGTTCTGCGTCGCTCACTCTGGGAGCTG           TAGACCGGAGCTGTTCCTATTCGGCCATCTTGGCTCCTCCCCCTCACTACAAAGGGTTTTGATGATTT       ATCTTTTGTATGTCTTCCCACAGGGCAGTGGCAGGTGTTTGGGCCAGACAAGCCTGTCCAGGCCTTGG       TGGGGGAGGACGCAGCATTCTCCTGTTTCCTGTCTCCTAAAACCAATGCAGAGGCCATGGAAGTGCGG       TTCTTCAGGGGCCAGTTCTCTAGCGTGGTCCACCTCTACAGGGACGGGAAGGACCAGCCATTTATGCA       GATGCCACAGTATCAAGGCAGGACAAAACTGTGAAGGATTCTATTGCGGAGGGGCGCATCTCTCGAGG       CTGGAAAACATTACTGTGTTGGATGCTGGCCTCTATGGGTGCAGGATTAGTTCCCAGTCTTACTACCA       GAAGGCCATCTGGGAGCTACAGGTGTCAGCACTGGGCTCAGTTCCTCTCATTTCCATCACGGGATATG       TTGATAGAGACATCCAGCTACTCTGTCAGTCCTCGGGCTGGTTCCCCCGGCCCGTGCAAGGAGCCAGC       GTCGTGTTTGTGCCTTGTACACTCCTGTGTCCACCACTGAATATACTGTTTCTGTTTCAGGGAAAATC       CAGGCGGAACTGGGTAAGTATGTGTCATGTCCTGAGCCTCCCACACATGGTTCTCCCGGGTCCCTCCC       TGATCCACAGTTTGAGCCTCTGGACGACCCTGGCTGCAGGCTGGACAGGAAGCACCGACTGGAGAAGA       AAGCACGGACAGGCAGAATTGAGAGACGCCCGGAAACACGCAGTGGAGGTGACTCTGGATCCAGAGAC       GGCTCACCCGAAGCTCTGCGTTTCTGATCTGAAAACTGTAACCCATAGAAAAGCTCCCCAGGAGGTGC       CTCACTCTGAGAAGAGATTTACAAGGAAGAGTGTGGTGGCTTCTCAGAGTTTCCAAGCAGGGAAACAT       TACTGGGAGGTGGACGGAGGACACAATAAAAGGTGGCGCGTGGGAGTGTGCCGGGATGATGTGGACAG       GAGGAAGGAGTACGTGACTTTGTCTCCCGATCATGGGTACTGGGTCCTCAGACTGAATGGAGAACATT       TGTATTTCACATTAAATCCCCGTTTTATCAGCGTCTTCCCCAGGACCCCACCTACAAAAATAGGGGTC       TTCCTGGACTATGAGTGTGGGACCATCTCCTTCTTCAACATAAATGACCAGTCCCTTATTTATACCCT       GACATGTCGGTTTGAAGGCTTATTGAGGCCCTACATTGAGTATCCGTCCTATAATGAGCAAAATGGAA       CTCCCATAGTCATCTGCCCAGTCACCCAGGAATCAGAGAAAGAGGCCTCTTGGCAAAGGGCCTCTGCA       ATCCCAGAGACAAGCAACAGTGAAGTCCTCCTCACAGGCAACCACGCCCTTCCTCCCCAGGGGTGAA                                         NOV20d, CG53449-02                                     Protein Sequence   SEQ ID NO: 496   497 aa   MW at 55724.3kD                             MNPVPQMEMQKSPMFCVAHSGSCRPELFLFGHLGSSPSLQRVLMTYLLYVFPQGSGRCLGQTSLSRPW           WGRTQHSPVSCLLKPMQRPWKCGSSGASSLAWSTSTGTGRTSHLCRCHSIKAGQNCEGFYCGGAHLSR       LENITVLDAGLYGCRISSQSYYQKAIWELQVSALGSVPLISITGYVDRDIQLLCQSSGWFPRPVQGAS       VVFVPCTLLCPPLNILFLFQGKSRRNWVSMCHVLSLPHNVLPGPSLIHSLSLWTTLAAGWTGSTDWRR       KHGQAELRDARKHAVEVTLDPETAHPKLCVSDLKTVTHRKAPQEVPHSEKRFTRKSVVASQSFQAGKH       YWEVDGGHNKRWRVGVCRDDVDRRKEYVTLSPDHGYWVLRLNGEHLYFTLNPRFISVFPRTPPTKIGV       FLDYECGTISFFNINDQSLIYTLTCRFEGLLRPYIEYPSYNEQNGTPIVICPVTQESEKEASWQRASA       IPETSNSEVLLTGNHALPPQG                                             NOV20e, CG53449-05   SEQ ID NO: 497   661 bp                             DNA Sequence   ORF Start: at 11   ORF Stop: at 653                             CACCAAGCTTCAGTGGCAGGTGTTTGGGCCAGACAAGCCTGTCCAGGCCTTGGTGGGGGAGGACGCAG           CATTCTCCTGTTTCCTGTCTCCTAAGACCAATGCAGAGGCCATGGAAGTGCGGTTCTTCAGGGGCCAG       TTCTCTAGCGTGGTCCACCTCTACAGGGACGGGAAGGACCAGCCATTTATGCAGATGCCACAGTATCA       AGGCAGGACAAAACTGGTGAAGGATTCTATTGCGGAGGGGCGCATCTCTCTGAGGCTGGAAAACATTA       CTGTGTTGGATGCTGGCCTCTATGGGTGCAGGATTAGTTCCCAGTCTTACTACCAGAAGGCCATCTGG       GAGCTACAGGTGTCAGCACTGGGCTCAGTTCCTCTCATTTCCATCACGGGATATGTTGATAGAGACAT       CCAGCTACTCTGTCAGTCCTCGGGCTGGTTCCCCCGGCCCACAGCGAAGTGGAAAGGTCCACAAGGAC       AGGATTTGTCCACAGACTCCAGGACAAACAGAGACATGCATGGCCTGTTTGATGTGGAGATCTCTCTG       ACCGTCCAAGAGAACGCCGGGAGCATATCCTGTTCCATGCGGCATGCTCATCTGAGCCGAGAGGTGGA       ATCCAGGGTACAGATAGGAGATACCTTTTTCGAGCCTATACTCGAGGGC                                         NOV20e, CG53449-05                                     Protein Sequence   SEQ ID NO: 498   214 aa   MW at 24072.0kD                             QWQVFGPDKPVQALVGEDAAFSCFLSPKTNAEAMEVRFFRGQFSSVVHLYRDGKDQPFMQMPQYQGRT           KLVKDSIAEGRISLRLENITVLDAGLYGCRISSQSYYQKAIWELQVSALGSVPLISITGYVDRDIQLL       CQSSGWFPRPTAKWKGPQGQDLSTDSRTNRDMHGLFDVEISLTVQENAGSISCSMRHAHLSREVESRV       QIGDTFFEPI                                             NOV20f, CG53449-06   SEQ ID NO: 499   1066 bp                             DNA Sequence   ORF Start: ATG at 17   ORF Stop: at 1058                             CACCAAGCTTCCCACCATGGCTCTCATGCTCAGTTTGGTTCTGAGTCTCCTCAAGCTGGGATCAGGGC           AGTGGCAGGTGTTTGGGCCAGACAAGCCTGTCCAGGCCTTGGTGGGGGAGGACGCAGCATTCTCCTGT       TTCCTGTCTCCTAAGACCAATGCAGAGGCCATGGAAGTGCGGTTCTTCAGGGGCCAGTTCTCTAGCGT       GGTCCACCTCTACAGGGACGGGAAGGACCAGCCATTTATGCAGATGCCACAGTATCAAGGCAGGACAA       AACTGGTGAAGGATTCTATTGCGGAGGGGCGCATCTCTCTGAGGCTGGAAAACATTACTGTGTTGGAT       GCTGGCCTCTATGGGTGCAGGATTAGTTCCCAGTCTTACTACCAGAAGGCCATCTGGGAGCTACAGGT       GTCAGCACTGGGCTCAGTTCCTCTCATTTCCATCACGGGATATGTTGATAGAGACATCCAGCTACTCT       GTCAGTCCTCGGGCTGGTTCCCCCGGCCCACAGCGAAGTGGAAAGGTCCACAAGGACAGGATTTGTCC       ACAGACTCCAGGACAAACAGAGACATGCATGGCCTGTTTGATGTGGAGATCTCTCTGACCGTCCAAGA       GAACGCCGGGAGCATATCCTGTTCCATGCGGCATGCTCATCTGAGCCGAGAGGTGGAATCCAGGGTAC       AGATAGGAGATACCTTTTTCGAGCCTATATCGTGGCACCTGGCTACCAAAGTACTGGGAATACTCTGC       TGTGGCCTATTTTTTGGCATTGTTGGACTGAAGATTTTCTTCTCCAAATTCCAGTGTAAGCGAGAGAG       AGAAGCATGGGCCGGTGCCTTATTCATGGTTCCAGCAGGGACAGGATCAGAGATGCTCCCACATCCAG       CTGCTTCTCTTCTTCTAGTCCTAGCCTCCAGGGGCCCAGGCCCAAAAAAGGAAAATCCAGGCGGAACT       GGACTGGAGAAGAAAGCACGGACAGGCAGAATTGAGAGACGCCCGGAAACACGCAGTGGAGGTGACTC       TGGATCCAGAGACGGCTCACCCGAAGCTCTGCGTTTCCTCGAGGGC                                         NOV20f, CG53449-06                                     Protein Sequence   SEQ ID NO: 500   347 aa   MW at 38208.5kD                             MALMLSLVLSLLKLGSGQWQVFGPDKPVQALVGEDAAFSCFLSPKTNAEAMEVRFFRGQFSSVVHLYR           DGKDQPFMQMPQYQGRTKLVKDSIAEGRISLRLENITVLDAGLYGCRISSQSYYQKAIWELQVSALGS       VPLISITGYVDRDIQLLCQSSGWFPRPTAKWKGPQGQDLSTDSRTNRDMHGLFDVEISLTVQENAGSI       SCSMRHAHLSREVESRVQIGDTFFEPISWHLATKVLGILCCGLFFGIVGLKIFFSKFQCKREREAWAG       ALFMVPAGTGSEMLPHPAASLLLVLASRGPGPKKENPGGTGLEKKARTGRIERRPETRSGGDSGSRDG       SPEALRF                                                 SEQ ID NO: 501   1969 bp                                 NOV20g, SNP13382434 of   ORF Start: ATG at 95   ORF Stop: TAG at 1595                             CG53449-03, DNA Sequence   SNP Pos: 396   SNP Change: T to C                             AGCATTAGGCCAGTTCTCCTCTTCTCTCTAATCCATCCGTCACCTCTCCTGTCATCCGTTTCCATGCC           GTGAGGTCCATTCACAGAACACATCCATGGCTCTCATGCTCAGTTTGGTTCTGAGTCTCCTCAAGCTG       GGATCAGGGCAGTGGCAGGTGTTTGGGCCAGACAAGCCTGTCCAGGCCTTGGTGGGGGAGGACGCAGC       ATTCTCCTGTTTCCTGTCTCCTAAGACCAATGCAGAGGCCATGGAAGTGCGGTTCTTCAGGGGCCAGT       TCTCTAGCGTGGTCCACCTCTACAGGGACGGGAAGGACCAGCCATTTATGCAGATGCCACAGTATCAA       GGCAGGACAAAACTGGTGAAGGATTCTATTGCGGAGGGGCGCATCTCTCTGAGGCCGGAAAACATTAC       TGTGTTGGATGCTGGCCTCTATGGGTGCAGGATTAGTTCCCAGTCTTACTACCAGAAGGCCATCTGGG       AGCTACAGGTGTCAGCACTGGGCTCAGTTCCTCTCATTTCCATCACGGGATATGTTGATAGAGACATC       CAGCTACTCTGTCAGTCCTCGGGCTGGTTCCCCCGGCCCACAGCGAAGTGGAAAGGTCCACAAGGACA       GGATTTGTCCACAGACTCCAGGACAAACAGAGACATGCATGGCCTGTTTGATGTGGAGATCTCTCTGA       CCGTCCAAGAGAACGCCGGGAGCATATCCTGTTCCATGCGGCATGCTCATCTGAGCCGAGAGGTGGAA       TCCAGGGTACAGATAGGAGATACCTTTTTCGAGCCTATATCGTGGCACCTGGCTACCAAAGTACTGGG       AAATCCAGGCGGAACTGGACTGGAGAAGAAAGCACGGACAGGCAGAATTGAGAGACGCCCGGAAACAC       GCAGTGGAGGTGACTCTGGATCCAGAGACGGCTCACCCGAAGCTCTGCGTTTCTGATCTGAAAACTGT       AACCCATAGAAAAGCTCCCCAGGAGGTGCCTCACTCTGAGAAGAGATTTACAAGGAAGAGTGTGGTGG       CTTCTCAGAGTTTCCAAGCAGGGAAACATTACTGGGAGGTGGACGGAGGACACAATAAAAGGTGGCGC       GTGGGAGTGTGCCGGGATGATGTGGACAGGAGGAAGGAGTACGTGACTTTGTCTCCCGATCATGGGTA       CTGGGTCCTCAGACTGAATGGAGAACATTTGTATTTCACATTAAATCCCCGTTTTATCAGCGTCTTCC       CCAGGACCCCACCTACAAAAATAGGGGTCTTCCTGGACTATGAGTGTGGGACCATCTCCTTCTTCAAC       ATAAATGACCAGTCCCTTATTTATACCCTGACATGTCGGTTTGAAGGCTTATTGAGGCCCTACATTGA       GTATCCGTCCTATAATGAGCAAAATGGAACTCCCATAGTCATCTGCCCAGTCACCCAGGAATCAGAGA       AAGAGGCCTCTTGGCAAAGGGCCTCTGCAATCCCAGAGACAAGCAACAGTGAATCCTCCTCACAGGCA       ACCACGCCCTTCCTCCCCAGGGGTGAAATGTAGGATGAATCACATCCCACATTCTTCTTTAGGGATAT       TAAGGTCTCTCTCCCAGATCCAAAGTCCCGCAGCAGCCGGCCAAGGTGGCTTCCAGATGAAGGGGGAC       TGGCCTGTCCACATGGGAGTCAGGTGTCATGGCTGCCCTGAGCTGGGAGGGAAGAAGGCTGACATTAC       ATTTAGTTTGCTCTCACTCCATCTGGCTAAGTGATCTTGAAATACCACCTCTCAGGTGAAGAACCGTC       AGGAATTCCCATCTCACAGGCTGTGGTGTAGATTAAGTAGACAAGGAATGTGAATAATGCTTAGATCT       TATTGATGACAGAGTGTATCCTAATGGTTTGTTCATTATATTACACTTTCAGTAAAAAAAAAAAA                                                 NOV20g, SNP13382434 of   SEQ ID NO: 502       MW at 56731.1kD                                 CG53449-03, Protein Sequence   SNP Pos: 101   500 aa   SNP Change: Leu to Pro                             MALMLSLVLSLLKLGSGQWQVFGPDKPVQALVGEDAAFSCFLSPKTNAEAMEVRFFRGQFSSVVHLYR           DGKDQPFMQMPQYQGRTKLVKDSIAEGRISLRPENITVLDAGLYGCRISSQSYYQKAIWELQVSALGS       VPLISITGYVDRDIQLLCQSSGWFPRPTAKWKGPQGQDLSTDSRTNRDMHGLFDVEISLTVQENAGSI       SCSMRHAHLSREVESRVQIGDTFFEPISWHLATKVLGILCCGLFFGIVGLKIFFSKFQWKIQAELDWR       RKNGQAELRDARKHAVEVTLDPETAHPKLCVSDLKTVTHRKAPQEVPHSEKRFTRKSVVASQSFQAGK       HYWEVDGGHNKRWRVGVCRDDVDRRKEYVTLSPDHGYWVLRLNGEHLYFTLNPRFISVFPRTPPTKIG       VFLDYECGTISFFNINDQSLIYTLTCRFEGLLRPYIEYPSYNEQNGTPIVICPVTQESEKEASWQRAS       AIPETSNSESSSQATTPFLPRGEM                                                 SEQ ID NO: 503   1969 bp                                 NOV20h, SNP13382441 of   ORF Start: ATG at 95   ORF Stop: TAG at 1595                             CG53449-03, DNA Sequence   SNP Pos: 1549   SNP Change: A to G                             AGCATTAGGCCAGTTCTCCTCTTCTCTCTAATCCATCCGTCACCTCTCCTGTCATCCGTTTCCATGCC           GTGAGGTCCATTCACAGAACACATCCATGGCTCTCATGCTCAGTTTGGTTCTGAGTCTCCTCAAGCTG       GGATCAGGGCAGTGGCAGGTGTTTGGGCCAGACAAGCCTGTCCAGGCCTTGGTGGGGGAGGACGCAGC       ATTCTCCTGTTTCCTGTCTCCTAAGACCAATGCAGAGGCCATGGAAGTGCGGTTCTTCAGGGGCCAGT       TCTCTAGCGTGGTCCACCTCTACAGGGACGGGAAGGACCAGCCATTTATGCAGATGCCACAGTATCAA       GGCAGGACAAAACTGGTGAAGGATTCTATTGCGGAGGGGCGCATCTCTCTGAGGCTGGAAAACATTAC       TGTGTTGGATGCTGGCCTCTATGGGTGCAGGATTAGTTCCCAGTCTTACTACCAGAAGGCCATCTGGG       AGCTACAGGTGTCAGCACTGGGCTCAGTTCCTCTCATTTCCATCACGGGATATGTTGATAGAGACATC       CAGCTACTCTGTCAGTCCTCGGGCTGGTTCCCCCGGCCCACAGCGAAGTGGAAAGGTCCACAAGGACA       GGATTTGTCCACAGACTCCAGGACAAACAGAGACATGCATGGCCTGTTTGATGTGGAGATCTCTCTGA       CCGTCCAAGAGAACGCCGGGAGCATATCCTGTTCCATGCGGCATGCTCATCTGAGCCGAGAGGTGGAA       TCCAGGGTACAGATAGGAGATACCTTTTTCGAGCCTATATCGTGGCACCTGGCTACCAAAGTACTGGG       AATACTCTGCTGTGGCCTATTTTTTGGCATTGTTGGACTGAAGATTTTCTTCTCCAAATTCCAGTGGA       AAATCCAGGCGGAACTGGACTGGAGAAGAAAGCACGGACAGGCAGAATTGAGAGACGCCCGGAAACAC       GCAGTGGAGGTGACTCTGGATCCAGAGACGGCTCACCCGAAGCTCTGCGTTTCTGATCTGAAAACTGT       AACCCATAGAAAAGCTCCCCAGGAGGTGCCTCACTCTGAGAAGAGATTTACAAGGAAGAGTGTGGTGG       CTTCTCAGAGTTTCCAAGCAGGGAAACATTACTGGGAGGTGGACGGAGGACACAATAAAAGGTGGCGC       GTGGGAGTGTGCCGGGATGATGTGGACAGGAGGAAGGAGTACGTGACTTTGTCTCCCGATCATGGGTA       CTGGGTCCTCAGACTGAATGGAGAACATTTGTATTTCACATTAAATCCCCGTTTTATCAGCGTCTTCC       ATAAATGACCAGTCCCTTATTTATACCCTGACATGTCGGTTTGAAGGCTTATTGAGGCCCTACATTGA       GTATCCGTCCTATAATGAGCAAAATGGAACTCCCATAGTCATCTGCCCAGTCACCCAGGAATCAGAGA       AAGAGGCCTCTTGGCAAAGGGCCTCTGCAATCCCAGAGACAAGCAACAGTGAGTCCTCCTCACAGGCA       TGGCCTGTCCACATGGGAGTCAGGTGTCATGGCTGCCCTGAGCTGGGAGGGAAGAAGGCTGACATTAC       ATTTAGTTTGCTCTCACTCCATCTGGCTAAGTGATCTTGAAATACCACCTCTCAGGTGAAGAACCGTC       AGGAATTCCCATCTCACAGGCTGTGGTGTAGATTAAGTAGACAAGGAATGTGAATAATGCTTAGATCT       TATTGATGACAGAGTGTATCCTAATGGTTTGTTCATTATATTACACTTTCAGTAAAAAAAAAAAA                                                 NOV20h, SNP13382441 of   SEQ ID NO: 504       MW at 56747.1kD                                 CG53449-03, Protein Sequence   500 aa   SNP Pos: 485   SNP Change: Glu to Glu                             MALMLSLVLSLLKLGSGQWQVFGPDKPVQALVGEDAAFSCFLSPKTNAEAMEVRFFRGQFSSVVHLYR           DGKDQPFMQMPQYQGRTKLVKDSIAEGRISLRLENITVLDAGLYGCRISSQSYYQKAIWELQVSALGS       VPLISITGYVDRDIQLLCQSSGWFPRPTAKWKGPQGQDLSTDSRTNRDMHGLFDVEISLTVQENAGSI       SCSMRHAHLSREVESRVQIGDTFFEPISWHLATKVLGILCCGLFFGIVGLKIFFSKFQWKIQAELDWR       RKHGQAELRDARKHAVEVTLDPETAHPKLCVSDLKTVTHRKAPQEVPHSEKRFTRKSVVASQSFQAGK       HYWEVDGGHNKRWRVGVCRDDVDRRKEYVTLSPDHGYWVLRLNGEHLYFTLNPRFISVFPRTPPTKIG       VFLDYECGTISFFNINDQSLIYTLTCRFEGLLRPYIEYPSYNEQNGTPIVICPVTQESEKEASWQRAS       AIPETSNSESSSQATTPFLPRGEM                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 20B.  
               TABLE 20B                       Comparison of the NOV20 protein sequences.                                            NOV20a   MALMLSLVLSLLKLGSGQWQVFGPDKPVQALVGEDAAFSCFLSPKTNAEAMEVRFFRGQF                   NOV20b   MALMLSLVLSLLKLGSGQWQVFGPDKPVQALVGEDAAFSCFLSPKTNAEAMEVRFFRGQF               NOV20c   --MNPVPQMEMQKSPMFCVAHSGSCRPELFLFGHLGSSPSLQRVLMIYLLYVFPQ               NOV20d   --MNPVPQMEMQKSPMFCVAHSGSCRPELFLFGHLGSSPSLQRVLMIYLLYVFPQ               NOV20e   -----------------QWQVFGPDKPVQALVGEDAAFSCFLSPKTNAEAMEVRFFRGQF               NOV20f   MALMLSLVLSLLKLGSGQWQVFGPDKPVQALVGEDAAFSCFLSPKTNAEAMEVRFFRGQF               NOV20a   SSVVHLYRDGKDQPFMQMPQYQGRTKLVKDSIAEGRIS----------------------               NOV20b   SSVVHLYRDGKDQPFMQMPQYQGRTKLVKDSIAEGRIS----------------------               NOV20c   GSGRCLGQTSLSRPWWGRTQHSPVSCLLKPM-----------------------------               NOV20d   GSGRCLGQTSLSRPWWGRTQHSPVSCLLKPMQRPWKCGSSGASSLAWSTSTGTGRTSHLC               NOV20e   SSVVHLYRDGKDQPFMQMPQYQGRTKLVKDSIAEGRIS----------------------               NOV20f   SSVVHLYRDGKDQPFMQMPQYQGRTKLVKDSIAEGRIS----------------------               NOV20a   ---------------------LRLENITVLDAGLYGCRISSQSYYQKAIWELQVSALGSV               NOV20b   ---------------------LRLENITVLDAGLYGCRISSQSYYQKAIWELQVSALGSV               NOV20c   ------------------------------------------------------------               NOV20d   RCHSIKAGQNCEGFYCGGAHLSRLENITVLDAGLYGCRISSQSYYQKAIWELQVSALGSV               NOV20e   ---------------------LRLENITVLDAGLYGCRISSQSYYQKAIWELQVSALGSV               NOV20f   ---------------------LRLENITVLDAGLYGCRISSQSYYQKAIWELQVSALGSV               NOV20a   PLISITGYVDRDIQLLCQSSGWFPRPTAKWKGPQGQDLSTDSRTNRDMHGLFDVEISLTV               NOV20b   PLISITGYVDRDIQLLCQSSGWFPRPTAKWKGPQGQDLSTDSRTNRDMHGLFDVEISLTV               NOV20c   ------------------------------------------------------------               NOV20d   PLISITGYVDRDIQLLCQSSGWFPRPVQGAS------VVFVPCTLLCPPLNILFLFQGKS               NOV20e   PLISITGYVDRDIQLLCQSSGWFPRPTAKWKGPQGQDLSTDSRTNRDMHGLFDVEISLTV               NOV20f   PLISITGYVDRDIQLLCQSSGWFPRPTAKWKGPQGQDLSTDSRTNRDMHGLFDVEISLTV               NOV20a   QENAGSISCSMRHAHLSREVESRVQIGDTFFEPISWHLATKVLGILCCGLFFGIVGLKIF               NOV20b   QENAGSISCSMRHAHLSREVESRVQIGDTFFEPISWHLATKVLGILCCGLFFGIVGLKIF               NOV20c   ------------------------------------------------------------               NOV20d   RRNWVSMCHVLSLPHMVLPGPSLIHSLSLWTTLAAGWTGSTDWRRKHGQAELRDARKHAV               NOV20e   QENAGSISCSMRHAHLSREVESRVQIGDTFFEPI--------------------------               NOV20f   QENAGSISCSMRHAHLSREVESRVQIGDTFFEPISWHLATKVLGILCCGLFFGIVGLKIF               NOV20a   FSKFQCKRERE--------------------------------AWAGALFMVPAGTGSEM               NOV20b   FSKFQWKIQAELDWRRKHGQAELRDARKHAVEVTLDPETAHPKLCVSDLKTVTHRKAPQE               NOV20c   ------------------------------------------------------------               NOV20d   EVTLDPETAHP-------------------------------KLCVSDLKTVTHRKAPQE               NOV20e   ------------------------------------------------------------               NOV20f   FSKFQCKRERE--------------------------------AWAGALFMVPAGTGSEM               NOV20a   LPHP---AASLLLVLASRGPGPKKENPGGTGLEKKARTGRIERRPETRSGGDSGSRDGSP               NOV20b   VPHSEKRFTRKSVVASQSFQAGKHYWEVDGGHNKRWRVGVCRDDVDRRKEYVTLSPDHGY               NOV20c   ------------------------------------------------------------               NOV20d   VPHSEKRFTRKSVVASQSFQAGKHYWEVDGGHNKRWRVGVCRDDVDRRKEYVTLSPDHGY               NOV20e   ------------------------------------------------------------               NOV20f   LPHP---AASLLLVLASRGPGPKKENPGGTGLEKKARTGRIERRPETRSGGDSGSRDGSP               NOV20a   EALRF-------------------------------------------------------               NOV20b   WVLRLNGEHLYFTLNPRFISVFPRTPPTKIGVFLDYECGTISFFNINDQSLIYTLTCRFE               NOV20c   ------------------------------------------------------------               NOV20d   WVLRLNGEHLYFTLNPRFISVFPRTPPTKIGVFLDYECGTISFFNINDQSLIYTLTCRFE               NOV20e   ------------------------------------------------------------               NOV20f   EALRF-------------------------------------------------------               NOV20a   ------------------------------------------------------------               NOV20b   GLLRPYIEYPSYNEQNGTPIVICPVTQESEKEASWQRASAIPETSNSESSSQATTPFLPR               NOV20c   ------------------------------------------------------------               NOV20d   GLLRPYIEYPSYNEQNGTPIVICPVTQESEKEASWQRASAIPETSNSEVLLTGNHALPPQ               NOV20e   ------------------------------------------------------------               NOV20f   ------------------------------------------------------------               NOV20a   ---               NOV20b   GEM               NOV20c   ---               NOV20d   G--               NOV20e   ---               NOV20f   ---               NOV20a   (SEQ ID NO: 490)               NOV20b   (SEQ ID NO: 492)               NOV20c   (SEQ ID NO: 494)               NOV20d   (SEQ ID NO: 496)               NOV20e   (SEQ ID NO: 498)               NOV20f   (SEQ ID NO: 500)                  
 
      Further analysis of the NOV20a protein yielded the following properties shown in Table 20C.  
               TABLE 20C                       Protein Sequence Properties NOV20a                                        SignalP analysis:   Cleavage site between residues 18 and 19       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 0; pos. chg 0; neg. chg 0           H-region:   length 12; peak value 10.45           PSG score:   6.05                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −0.59           possible cleavage site: between 17 and 18                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 17)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 18           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 242-258               −7.06                             PERIPHERAL   Likelihood = 2.17 (at 126)                         ALOM score: −7.06 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 8           Charge difference: 0.0 C(1.0)-N(1.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 1a (cytoplasmic tail 259 to 347)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   1.22           Hyd Moment(95):   2.65   G content:   3           D/E content:   1   S/T content:   3                         Score: −6.60       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 11.8%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: found                         LL at 293                 checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 76.7       COIL:   Lupas&#39; s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         44.4%: endoplasmic reticulum           22.2%: Golgi           22.2%: extracellular, including cell wall           11.1%: plasma membrane                 &gt;&gt; prediction for CG53449-04 is end (k = 9)                  
 
      A search of the NOV20a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 20D.  
               TABLE 20D                          Geneseq Results for NOV20a                                         NOV20a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               AAU83681   Human PRO protein, Seq ID No 180 -   1 . . . 268   264/268 (98%)   e−152             Homo sapiens , 500 aa.   1 . . . 268   265/268 (98%)           [WO200208288-A2, 31-JAN-2002]       ABB84917   Human PRO1347 protein sequence   1 . . . 268   264/268 (98%)   e−152           SEQ ID NO: 202 -  Homo sapiens , 500   1 . . . 268   265/268 (98%)           aa. [WO200200690-A2, 03-JAN-2002]       AAE20317   Human B7-H13 protein #1 -  Homo     1 . . . 268   264/268 (98%)   e−152             sapiens , 461 aa. [WO200202587-A1 ,   1 . . . 268   265/268 (98%)           10-JAN-2002]       ABB95523   Human angiogenesis related protein   1 . . . 268   264/268 (98%)   e−152           PRO1347 SEQ ID NO: 202 -  Homo     1 . . . 268   265/268 (98%)             sapiens , 500 aa. [WO200208284-A2,           31-JAN-2002]       ABG95892   Human secreted/transmembrane   1 . . . 268   264/268 (98%)   e−152           protein PRO1347 -  Homo sapiens , 500   1 . . . 268   265/268 (98%)           aa. [US2002119130-A1, 29-AUG-2002]                  
 
      In a BLAST search of public sequence databases, the NOV20a protein was found to have homology to the proteins shown in the BLASTP data in Table 20E.  
               TABLE 20E                          Public BLASTP Results for NOV20a                                         NOV20a               Protein       Residues/   Identities/       Accession       Match   Similarities for the   Expect       Number   Protein/Organism/Length   Residues   Matched Portion   Value                                             Q9H730   Hypothetical protein FLJ21458 -    1 . . . 347   347/347   (100%)   0.0             Homo sapiens  (Human), 347 aa.    1 . . . 347   347/347   (100%)       Q9Y2C7   Butyrophilin like receptor -  Homo      1 . . . 157   111/157   (70%)   5e−55             sapiens  (Human), 432 aa.    1 . . . 157   126/157   (79%)       O73716   B-G-like protein -  Grus americana      7 . . . 268   103/266   (38%)   3e−45           (whooping crane), 280 aa.   17 . . . 280   154/266   (57%)       Q96DM5   Hypothetical protein FLJ32535 -    2 . . . 252   104/259   (40%)   3e−44             Homo sapiens  (Human), 315 aa.   19 . . . 277   159/259   (61%)       P18892   Butyrophilin precursor (BT) -  Bos      3 . . . 249   96/254   (37%)   3e−42             taurus  (Bovine), 526 aa.   13 . . . 266   153/254   (59%)                  
 
      PFam analysis predicts that the NOV20a protein contains the domains shown in the Table 20F.  
               TABLE 20F                       Domain Analysis of NOV20a                                                        Pfam   NOV20a   Identities/   Expect           Domain   Match Region   Similarities   Value                   for the                   Matched Region                      
 
     Example 21  
      The NOV21 clone was analyzedi and the nucleotide and encoded polypeptide sequences are shown in Table 21A.  
               TABLE 21A                       NOV21 Sequence Analysis                                                NOV21a, CG53908-01   SEQ ID NO: 505   2881 bp                             DNA Sequence   ORF Start: ATG at 87   ORF Stop: TGA at 2784                             AGCTGGGGCTCCGGGCTGAGGCGCTAAAGCCGCCCTCCCGCCCGCGGGGCCCCGCGCCCGGCCCGCCC           GCCTGCCCGCCCGCGGCCATGGCCGTCCGGCCCGGCCTGTGGCCAGCGCTCCTGGGCATAGTCCTCGC       CGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTG       CTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGT       GGACCACGTGATCGAGCGCAGCACAGACGGGAGCAGTGGTGAGCCGACCATGGAGGTCCGCATTAATG       TCTCAAGGCAGCAGGTCGAGAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGC       TCCTCGGGCACCACCAAGAGTCAGAAGGCCTACATCCGCATAGCCAGATTGCGCAAGAACTTCGAGCA       GGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGAA       TCCCTCCAGCCGAGGTGGAGTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTA       TACATCACGCGGGAGCACAGCCTGGTGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTG       CGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTG       GGTGGTCGACGTGGACCGAGTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGC       CGGAGCTGCACCAACCCGGCGCCTCTCAACGGGGGCGCTTTCTGTGAGGGGCAGAATGTCCATGACCG       CACCGTCTCCTCTCTGCTTGTCTCTGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTG       GGCTGGACTGCACCCACTGGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAG       TGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTACACAGTGCTTCTGGCCC       TGAGGACGTGGCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCTGCCTGGTCCTGCTGCTGCTTGTCC       TCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCGTCCATTCTCACC       TCAGGCTTCCAGCCCGTCAGCATCAAGCCCAGCAAAGCAGACAACCCCCATCTGCTCACCATCCAGCC       GGACCTCAGCACCACCACCACCTACCAGGGCAGTCTCTGTCCCCGGCAGGATGGGCCCAGCCCCAAGT       TCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACACACTGCACCACAGCTCT       CCCACCTCTGAGGCCGAGGAGTTCGTCTCCCGCCTCTCCACCCAGAACTACTTCCGCTCCCTGCCCCG       AGGCACCAGCAACATGACCTATGGGACCTTCAACTTCCTCGGGGGCCGGCTGATGATCCCTAATACAG       GTATCAGCCTCCTCATCCCCCCAGATGCCATACCCCGAGGGAAGATCTATGAGATCTACCTCACGCTG       CACAAGCCGGAAGACGTGAGGTTGCCCCTAGCTGGCTGTCAGACCCTGCTGAGTCCCATCGTTAGCTG       TGGACCCCCTGGCGTCCTGCTCACCCGGCCAGTCATCCTGGCTATGGACCACTGTGGGGAGCCCAGCC       CTGACAGCTGGAGCCTGCGCCTCAAAAAGCAGTCGTGCGAGGGCAGCTGGGAGCAGGATGTGCTGCAC       CTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCCTGCTACGTCTTCAC       CGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCGCCAAGCGCCTCAAGC       TGCTTCTGTTTGCGCCGGTGGCCTGCACCTCCCTCGAGTACAACATCCGGGTCTACTGCCTGCATGAC       ACCCACGATGCACTCAAGGAGGTGGTGCAGCTGGAGAAGCAGCTGGGGGGACAGCTGATCCAGGAGCC       ACGGGTCCTGCACTTCAAGGACAGTTACCACAACCTGCGCCTATCCATCCACGATGTGCCCAGCTCCC       TGTGGAAGAGTAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTTTATCACATCTGGAATGGCACGCAG       CGGTACTTGCACTGCACCTTCACCCTGGAGCGTGTCAGCCCCAGCACTAGTGACCTGGCCTGCAAGCT       GTGGGTGTGGCAGGTGGAGGGCGACGGGCAGAGCTTCAGCATCAACTTCAACATCACCAAGGACACAA       GGTTTGCTGAGCTGCTGGCTCTGGAGAGTGAAGCGGGGGTCCCAGCCCTGGTGGGCCCCAGTGCCTTC       AAGATCCCCTTCCTCATTCGGCAGAAGATAATTTCCAGCCTGGACCCACCCTGTAGGCGGGGTGCCGA       CTGGCGGACTCTGGCCCAGAAACTCCACCTGGACAGCCATCTCAGCTTCTTTGCCTCCAAGCCCAGCC       CCACAGCCATGATCCTCAACCTGTGGGAGGCGCGGCACTTCCCCAACGGCAACCTCAGCCAGCTGGCT       GCAGCAGTGGCTGGACTGGGCCAGCCAGACGCTGGCCTCTTCACAGTGTCGGAGGCTGAGTGCTGAGG       CCGGCCAGGCCCGACACCTACACTCTCACCAGCTTTGGCACCCACCAAGGACAGGCAGAAGCCGGACA       GGGGCCCTTCCCCACACCGGGGAGA                                         NOV21a, CG53908-01                                     Protein Sequence   SEQ ID NO: 506   899 aa   MW at 99063.0kD                             MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV           PATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTK       SQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH       SLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNP       APLNGGAFCEGQNVHDRTVSSLLVSVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDL       DTRNCTSDLCVHSASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPV       SIKPSKADNPHLLTIQPDLSTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE       EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDV       RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEQDVLHLGEEAP       SHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALK       EVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCT       FTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLI       RQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGL       GQPDAGLFTVSEAEC                                             NOV21b, CG53908-02   SEQ ID NO: 507   993 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             CAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACCCGGACCTGCTTCCCCACTTCCTGGT           GGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTGCTTGTGTGCAAGGCCGTGCCCGCCA       CGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGTGGACCACGTGATCGAGCGCAGCACA       GACGGGAGCAGTGGTGAGCCGACCATGGAGGTCCGCATTAATGTCTCAAGGCAGCAGGTCGAGAAGGT       GTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGCTCCTCGGGCACCACCAAGAGTCAGA       AGGCCTACATCCGCATAGCCAGATTGCGCAAGAACTTCGAGCAGGAGCCGCTGGCCAAGGAGGTGTCC       CTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCATCCCTCCAGCCGAGGTGGAGTGGCT       CCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTATACATCACGCGGGAGCACAGCCTGG       TGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTGCGTGGCCAAGAACATCGTGGCACGT       CGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTGGGTGGTCGACGTGGACCGAGTGGTC       CGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGCCGGAGCTGCACCAACCCGGCGCCTC       TCAACGGGGGCGCTTTCTGTGAGGGGCAGAATGTCCATGACCGCACCGTCTCCTCTCTGCTTGTCTCT       GTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTGGGCTGGACTGCACCCACTGGCGGAG       CCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAGTGCCAGGGCACTGACCTGGACACCC       GCAACTGTACCAGTGACCTCTGTGTACACAGTGCTTCTGGC                                         NOV21b, CG53908-02                                     Protein Sequence   SEQ ID NO: 508   331 aa   MW at 36604.8kD                             QQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERST           DGSSGEPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIARLRKNFEQEPLAKEVS       LEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVAR       RRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNPAPLNGGAFCEGQNVHDRTVSSLLVS       VDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHSASG                                             NOV21c, 306075989   SEQ ID NO: 509   1009 bp                             DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                             CACCGGATCCCAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACCCGGACCTGCTTCCCC           ACTTCCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTGCTTGTGTGCAAGGCC       GTGCCCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGTGGACCACGTGATCGA       GCGCAGCACAGACGGGAGCAGTGGGCTGCCCACCATGGAGGTCCGCATTAATGTCTCAAGGCAGCAGG       TCGAGAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGCTCCTCGGGCACCACC       AAGAGTCAGAAGGCCTACATCCGCATAGCCTATTTGCGCAAGAACTTCGAGCAGGAGCCACTGGCCAA       GGAGGTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCATCCCTCCAGCCGAGG       TGGAGTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTATACATCACGCGGGAG       CACAGCCTGGTGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTGCGTGGCCAAGAACAT       CGTGGCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTGGGTGGTCGACGTGGA       CCGAGTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGCCGGAGCTGCACCAAC       CCGGCGCCTCTCAACGGGGGCGCTTTCTGTGAGGGGCAGAATGTCCAGAAAACAGCCTGCGCCACCCT       GTGCCCAGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTGGGCTGGACTGCACCCACT       GGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAGTGCCAGGGCACTGACCTG       GACACCCGCAACTGTACCAGTGACCTCTGTGTACACAGTGCTTCTGGCGAATTCGGC                                         NOV21c, 306075989                                     Protein Sequence   SEQ ID NO: 510   336 aa   MW at 36996.3kD                             TGSQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIE           RSTDGSSGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAK       EVSLEQGIVLPCRPPEGIPPAEVEWLPNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNI       VARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNPAPLNGGAFCEGQNVQKTACATL       CPVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHSASGEFG                                             NOV21d, CG53908-03   SEQ ID NO: 511   1009 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: at 1006                             CAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACCCGGACCTGCTTCCCCACTTCCTGGT           GGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTGCTTGTGTGCAAGGCCGTGCCCGCCA       GACGGGAGCAGTGGTGAGCCGACCATGGAGGTCCGCATTAATGTCTCAAGGCAGCAGGTCGAGAAGGT       GTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGCTCCTCGGGCACCACCAAGAGTCAGA       AGGCCTACATCCGCATAGCCAGATTGCGCAAGAACTTCGAGCAGGAGCCGCTGGCCAAGGAGGTGTCC       CTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCATCCCTCCAGCCGAGGTGGAGTGGCT       CCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTATACATCACGCGGGAGCACAGCCTGG       TGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTGCGTGGCCAAGAACATCGTGGCACGT       CGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGACGGCAGCTGGAGCCCGTGGAGCAAGT       GGTCGGCCTGTGGGCTGGACTGCACCCACTGGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCAAC       GGAGGGGAGGAGTGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTACACAG       TGCTGCTTGTCCTCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCG       TCCATTCTCACCTCAGGCTTCCAGCCCGTCAGCATCAAGCCCAGCAAAGCAGACAAC                                         NOV21d, CG53908-03                                     Protein Sequence   SEQ ID NO: 512   335 aa   MW at 36949.6kD                             QQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERST           DGSSGEPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIARLRKNFEQEPLAKEVS       LEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVAR       RRSASAAVIVYVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHSA       SGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADN                                             NOV21e, CG53908-04   SEQ ID NO: 513   2752 bp                             DNA Sequence   ORF Start: ATG at 46   ORF Stop: TGA at 2740                             CCGCGGGGCCCCGCGCCCGGCCCGCCCGCCTGCCCGCCCGCGGCCATGGCCGTCCGGCCCGGCCTGTG           GCCAGCGCTCCTGGGCATAGTCCTCGCCGCTTGGCTCCGCGGCTCGGGTGCCCAGCAGAGTGCCACCG       TGGCCAACCCAGTGCCTGGTGCCAACCCGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTG       TACATCGTCAAGAACAAGCCAGTGCTGCTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAA       GTGCAACGGGGAGTGGGTGCGCCAGGTGGACCACGTGATCGAGCGCAGCACAGACGGGAGCAGTGGGC       TGCCCACCATGGAGGTCCGCATTAATGTCTCAAGGCAGCAGGTCGAGAAGGTGTTCGGGCTGGAGGAA       TACTGGTGCCAGTGCGTGGCATGGAGCTCCTCGGGCACCACCAAGAGTCAGAAGGCCTACATCCGCAT       AGCCAGATTGCGCAAGAACTTCGAGCAGGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCG       TGCTGCCCTGCCGTCCACCGGAGGGCATCCCTCCAGCCGAGGTGGAGTGGCTCCGGAACGAGGACCTG       GTGGACCCGTCCCTGGACCCCAATGTATACATCACGCGGGAGCACAGCCTGGTGGTGCGACAGGCCCG       CCTTGCTGACACGGCCAACTACACCTGCGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCG       CTGCTGTCATCGTCTACGTGAACGGTGGGTGGTCGACGTGGACCGAGTGGTCCGTCTGCAGCGCCAGC       TGTGGGCGCGGCTGGCAGAAACGGAGCCGGAGCTGCACCAACCCGGCGCCTCTCAACGGGGGCGCTTT       CTGTGAGGGGCAGAATGTCCAGAAAACAGCCTGCGCCACCCTGTGCCCAGTAGACGGCAGCTGGAGCC       CGTGGAGCAAGTGGTCGGCCTGTGGGCTGGACTGCACCCACTGGCGGAGCCGTGAGTGCTCTGACCCA       GCACCCCGCAACGGAGGGGAGGAGTGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCT       CTGTGTACACAGTGCTTCTGGCCCTGAGGACGTGGCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCT       GCCTGGTCCTGCTGCTGCTTGTCCTCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGAT       GTGGCTGACTCGTCCATTCTCACCTCAGGCTTCCAGCCCGTCAGCATCAAGCCCAGCAAGCAGACAAA       CCCCCATCTGCTCACCATCCAGCCGGACCTCAGCACCACCACCACCACCTACCAGGGCAGTCTCTGTC       CCCGGCAGGATGGGCCCAGCCCCAAGTTCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGC       GGCCGCCACACACTGCACCACAGCTCTCCCACCTCTGAGGCCGAGGAGTTCGTCTCCCGCCTCTCCAC       CCAGAACTACTTCCGCTCCCTGCCCCGAGGCACCAGCAACATGACCTATGGGACCTTCAACTTCCTCG       GGGGCCGGCTGATGATCCCTAATACAGGTATCAGCCTCCTCATCCCCCCAGATGCCATACCCCGAGGG       AAGATCTATGAGATCTACCTCACGCTGCACAAGCCGGAAGACGTGAGGTTGCCCCTAGCTGGCTGTCA       CTATGGACCACTGTGGGGAGCCCAGCCCTGACAGCTGGAGCCTGCGCCTCAAAAAGCAGTCGTGCGAG       GGCAGCTGGGAGGATGTGCTGCACCTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGA       GGCCAGTGCCTGCTACGTCTTCACCGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCG       TGGCTGCCGCCAAGCGCCTCAAGCTGCTTCTGTTTGCGCCGGTGGCCTGCACCTCCCTCGAGTACAAC       ATCCGGGTCTACTGCCTGCATGACACCCACGATGCACTCAAGGAGGTGGTGCAGCTGGAGAAGCAGCT       GGGGGGACAGCTGATCCAGGAGCCACGGGTCCTGCACTTCAAGGACAGTTACCACAACCTGCGCCTAT       CCATCCACGATGTGCCCAGCTCCCTGTGGAAGAGTAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTT       TATCACATCTGGAATGGCACGCAGCGGTACTTGCACTGCACCTTCACCCTGGAGCGTGTCAGCCCCAG       CACTAGTGACCTGGCCTGCAAGCTGTGGGTGTGGCAGGTGGAGGGCGACGGGCAGAGCTTCAGCATCA       ACTTCAACATCACCAAGGACACAAGGTTTGCTGAGCTGCTGGCTCTGGAGAGTGAAGCGGGGGTCCCA       GCCCTGGTGGGCCCCAGTGCCTTCAAGATCCCCTTCCTCATTCGGCAGAAGATAATTTCCAGCCTGGA       CCCACCCTGTAGGCGGGGTGCCGACTGGCGGACTCTGGCCCAGAAACTCCACCTGGACAGCCATCTCA       GCTTCTTTGCCTCCAAGCCCAGCCCCACAGCCATGATCCTCAACCTGTGGGAGGCGCGGCACTTCCCC       AACGGCAACCTCAGCCAGCTGGCTGCAGCAGTGGCTGGACTGGGCCAGCCAGACGCTGGCCTCTTCAC       AGTGTCGGAGGCTGAGTGCTGAGGCCGGCCAG                                         NOV21e, CG53908-04                                     Protein Sequence   SEQ ID NO: 514   898 aa   MW at 98841.9kD                             MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV           PATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTK       SQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH       SLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNP       APLNGGAFCEGQNVQKTACATLCPVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLD       TRNCTSDLCVHSASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVS       IKPSKADNPHLLTIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE       EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDV       RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEDVLHLGEEAPS       HLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALKE       VVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCTF       TLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLIR       QKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLG       QPDAGLFTVSEAEC                                             NOV21f, CG53908-05   SEQ ID NO: 515   1002 bp                             DNA Sequence   ORF Start: at 7   ORF Stop: at 997                             GGATCCCAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACCCGGACCTGCTTCCCCACTT           CCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTGCTTGTGTGCAAGGCCGTGC       CCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGTGGACCACGTGATCGAGCGC       AGCACAGACGGGAGCAGTGGGCTGCCCACCATGGAGGTCCGCATTAATGTCTCAAGGCAGCAGGTCGA       GAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGCTCCTCGGGCACCACCAAGA       GTCAGAAGGCCTACATCCGCATAGCCTATTTGCGCAAGAACTTCGAGCAGGAGCCACTGGCCAAGGAG       GTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCATCCCTCCAGCCGAGGTGGA       GTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTATACATCACGCGGGAGCACA       GCCTGGTGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTGCGTGGCCAAGAACATCGTG       GCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTGGGTGGTCGACGTGGACCGA       GTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGCCGGAGCTGCACCAACCCGG       CGCCTCTCAACGGGGGCGCTTTCTGTGAGGGGCAGAATGTCCAGAAAACAGCCTGCGCCACCCTGTGC       CCAGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTGGGCTGGACTGCACCCACTGGCG       GAGCCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAGTGCCAGGGCACTGACCTGGACA       CCCGCAACTGTACCAGTGACCTCTGTGTACACAGTGCTTCTGGCCTCGAG                                         NOV21f, CG53908-05                                     Protein Sequence   SEQ ID NO: 516   330 aa   MW at 36417.7kD                             QQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERST           DGSSGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVS       LEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVAR       RRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNPAPLNGGAFCEGQNVQKTACATLCPV       DGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHSASG                                             NOV21g, CG53908-06   SEQ ID NO: 517   2575 bp                             DNA Sequence   ORF Start: at 3   ORF Stop: TGA at 2502                             CAGCGCTCCTGGGCATAGTCCTCGCCGCTTGGCTCCGCGGCTCGGGTGCCCAGCAGAGTGCCACCGTG           GCCAACCCAGTGCCTGGTGCCAACCCGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTGTA       CATCGTCAAGAACAAGCCAGTGCTGCTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAAGT       GCAACGGGGAGTGGGTGCGCCAGGTGGACCACGTGATCGAGCGCAGCACAGACGGGAGCAGTGGGCTG       CCCACCATGGAGGTCCGCATTAATGTCTCAAGGCAGCAGGTCGAGAAGGTGTTCGGGCTGGAGGAATA       CTGGTGCCAGTGCGTGGCATGGAGCTCCTCGGGCACCACCAAGAGTCAGAAGGCCTACATCCGCATAG       CCTATTTGCGCAAGAACTTCGAGCAGGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCGTG       CTGCCCTGCCGTCCACCGGAGGGCATCCCTCCAGCCGAGGTGGAGTGGCTCCGGAACGAGGACCTGGT       GGACCCGTCCCTGGACCCCAATGTATACATCACGCGGGAGCACAGCCTGGTGGTGCGACAGGCCCGCC       TTGCTGACACGGCCAACTACACCTGCGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCGCT       GCTGTCATCGTCTACGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTGGGCTGGACTG       CACCCACTGGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAGTGCCAGGGCA       CTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTACACACTGCTTCTGGCCCTGAGGACGTG       GCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCTGCCTGGTCCTGCTGCTGCTTGTCCTCATCCTCGT       TTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCGTCCATTCTCACCTCAGGCTTCC       ACCACCACCACCACCTACCAGGGCAGTCTCTGTCCCCGGCAGGATGGGCCCAGCCCCAAGTTCCAGCT       CACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACACACTGCACCACAGCTCTCCCACCT       CTGAGGCCGAGGAGTTCGTCTCCCGCCTCTCCACCCAGAACTACTTCCGCTCCCTGCCCCGAGGCACC       AGCAACATGACCTATGGGACCTTCAACTTCCTCGGGGGCCGGCTGATGATCCCTAATACAGGAATCAG       CCTCCTCATCCCCCCAGATGCCATACCCCGAGGGAAGATCTATGAGATCTACCTCACGCTGCACAAGC       CGGAAGACGTGAGGTTGCCCCTAGCTGGCTGTCAGACCCTGCTGAGTCCCATCGTTAGCTGTGGACCC       CCTGGCGTCCTGCTCACCCGGCCAGTCATCCTGGCTATGGACCACTGTGGGGAGCCCAGCCCTGACAG       CTGGAGCCTGCGCCTCAAAAAGCAGTCGTGCGAGGGCAGCTGGGAGGATGTGCTGCACCTGGGCGAGG       AGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCCTGCTACGTCTTCACCGAGCAGCTG       GGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCGCCAAGCGCCTCAAGCTGCTTCTGTT       TGCGCCGGTGGCCTGCACCTCCCTCGAGTACAACATCCGGGTCTACTGCCTGCATGACACCCACGATG       CACTCAAGGAGGTGGTGCAGCTGGAGAAGCAGCTGGGGGGACAGCTGATCCAGGAGCCACGGGTCCTG       CACTTCAAGGACAGTTACCACAACCTGCGCCTATCCATCCACGATGTGCCCAGCTCCCTGTGGAAGAG       TAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTTTATCACATCTGGAATGGCACGCAGCGGTACTTGC       ACTGCACCTTCACCCTGGAGCGTGTCAGCCCCAGCACTAGTGACCTGGCCTGCAAGCTGTGGGTGTGG       CAGGTGGAGGGCGACGGGCAGAGCTTCAGCATCAACTTCAACATCACCAAGGACACAAGGTTTGCTGA       GCTGCTGGCTCTGGAGAGTGAAGCGGGGGTCCCAGCCCTGGTGGGCCCCAGTGCCTTCAAGATCCCCT       TCCTCATTCGGCAGAAGATAATTTCCAGCCTGGACCCACCCTGTAGGCGGGGTGCCGACTGGCGGACT       CTGGCCCAGAAACTCCACCTGGACAGCCATCTCAGCTTCTTTGCCTCCAAGCCCAGCCCCACAGCCAT       GATCCTCAACCTGTGGGAGGCGCGGCACTTCCCCAACGGCAACCTCAGCCAGCTGGCTGCAGCAGTGG       CTGGACTGGGCCAGCCAGACGCTGGCCTCTTCACAGTGTCGGAGGCTGAGTGCTGAGGCCGGCCAGGC       CCGACACCTACACTCTCACCAGCTTTGGCACCCACCAAGGACAGGCAGAAGCCGGACAG                                         NOV21g, CG53908-06                                     Protein Sequence   SEQ ID NO: 518   833 aa   MW at 91922.0kD                             ALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKC           NGEWVRQVDHVTERSTDGSSGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIA       YLRKNFEQEPLAKEVSLEQIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARL       ADTANYTCVAKNIVARRRSASAAVIVYVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGT       DLDTRNCTSDLCVHTASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQ       PVSIKPSKADNPHLLTIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTS       EAEEFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKP       EDVRLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEDVLHLGEE       APSHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDA       LKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLH       CTFTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPF       LIRQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVA       GLGQPDAGLFTVSEAEC                                             NOV21h, CG53908-07   SEQ ID NO: 519   2463 bp                             DNA Sequence   ORF Start: at 7   ORF Stop: at 2458                             GGATCCCAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACCCGGACCTGCTTCCCCACTT           CCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTGCTTGTGTGCAAGGCCGTGC       CCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGTGGACCACGTGATCGAGCGC       AGCACAGACGGGAGCAGTGGGCTGCCCACCATGGAGGTCCGCATTAATGTCTCAAGGCAGCAGGTCGA       GAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGCTCCTCGGGCACCACCAAGA       GTCAGAAGGCCTACATCCGCATAGCCTATTTGCGCAAGAACTTCGAGCAGGAGCCGCTGGCCAAGGAG       GTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCATCCCTCCAGCCGAGGTGGA       GTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTATACATCACGCGGGAGCACA       GCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGGACGGCAGCTGGAGCCCGTGGAGCAA       GTGGTCGGCCTGTGGGCTGGGCTGCACCCACTGGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCA       ACGGAGGGGAGGAGTGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTACAC       ACTGCTTCTGGCCCTGAGGACGTGGCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCTGCCTGGTCCT       GCTGCTGCTTGTCCTCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACT       CGTCCATTCTCACCTCAGGCTTCCAGCCCGTCAGCATCAAGCCCAGCAAAGCAGACAACCCCCATCTG       CTCACCATCCAGCCGGACCTCAGCACCACCACCACCACCTACCAGGGCAGTCTCTGTCCCCGGCAGGA       TGGGCCCAGCCCCAAGTTCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACA       CACTGCACCACAGCTCTCCCACCTCTGAGGCCGAGGAGTTCGTCTCCCGCCTCTCCACCCAGAACTAC       TTCCGCTCCCTGCCCCGAGGCACCAGCAACATGACCTATGGGACCTTCAACTTCCTCGGGGGCCGGCT       GATGATCCCTAATACAGGAATCAGCCTCCTCATCCCCCCAGATGCCATACCCCGAGGGAAGATCTATG       AGATCTACCTCACGCTGCACAAGCCGGAAGACGTGAGGTTGCCCCTAGCTGGCTGTCAGACCCTGCTG       AGTCCCATCGTTAGCTGTGGACCCCCTGGCGTCCTGCTCACCCGGCCAGTCATCCTGGCTATGGACCA       AGGATGTGCTGCACCTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCC       TGCTACGTCTTCACCGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCGC       CAAGCGCCTCAAGCTGCTTCTGTTTGCGCCGGTGGCCTGCACCTCCCTCGAGTACAACATCCGGGTCT       CTGATCCAGGAGCCACGGGTCCTGCACTTCAAGGACAGTTACCACAACCTGCGCCTATCCATCCACGA       TGTGCCCAGCTCCCTGTGGAAGAGTAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTTTATCACATCT       GGAATGGCACGCAGCGGTACTTGCACTGCACCTTCACCCTGGAGCGTGTCAGCCCCAGCACTAGTGAC       CTGGCCTGCAAGCTGTGGGTGTGGCAGGTGGAGGGCGACGGGCAGAGCTTCAGCATCAACTTCAACAT       CACCAAGGACACAAGGTTTGCTGAGCTGCTGGCTCTGGAGAGTGAAGCGGGGGTCCCAGCCCTGGTGG       GCCCCAGTGCCTTCAAGATCCCCTTCCTCATTCGGCAGAAGATAATTTCCAGCCTGGACCCACCCTGT       AGGCGGGGTGCCGACTGGCGGACTCTGGCCCAGAAACTCCACCTGGACAGCCATCTCAGCTTCTTTGC       GCTGAGTGCAAGCTT                                         NOV21h, CG53908-07                                     Protein Sequence   SEQ ID NO: 520   817 aa   MW at 90314.2kD                             QQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERST           DGSSGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVS       LEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVAR       RRSASAAVIVYVDGSWSPWSKWSACGLGCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHTA       SGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADNPHLLT       IQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAEEFVSRLSTQNYFR       SLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPLAGCQTLLSP       IVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEDVLHLGEEAPSHLYYCQLEASACY       VFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLI       QEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCTFTLERVSPSTSDLA       CKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLIRQKIISSLDPPCRR       GADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLGQPDAGLFTVSEAE       C                                                 SEQ ID NO: 521   2881 bp                                 NOV21i, SNP13382444 of   ORF Start: at 423   ORF Stop: end of sequence                             CG53908-01, DNA Sequence   SNP Pos: 420   SNP Change: C to T                             AGCTGGGGCTCCGGGCTGAGGCGCTAAAGCCGCCCTCCCGCCCGCGGGGCCCCGCGCCCGGCCCGCCC           GCCTGCCCGCCCGCGGCCATGGCCGTCCGGCCCGGCCTGTGGCCAGCGCTCCTGGGCATAGTCCTCGC       CGCTTGGCTCCGCGGCTCGGGTGCCCAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACC       CGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTG       CTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGT       GGACCACGTGATCGAGCGCAGCACAGACGGGAGCAGTGGTGAGCCGACCATGGAGGTCCGCATTAATG       TCTCAAGGCAGTAGGTCGAGAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGC       TCCTCGGGCACCACCAAGAGTCAGAAGGCCTACATCCGCATAGCCAGATTGCGCAAGAACTTCGAGCA       GGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCA       TCCCTCCAGCCGAGGTGGAGTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTA       TACATCACGCGGGAGCACAGCCTGGTGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTG       CGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTG       GGTGGTCGACGTGGACCGAGTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGC       CACCGTCTCCTCTCTGCTTGTCTCTGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTG       GGCTGGACTGCACCCACTGGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAG       TGAGGACGTGGCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCTGCCTGGTCCTGCTGCTGCTTGTCC       TCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCGTCCATTCTCACC       TCAGGCTTCCAGCCCGTCAGCATCAAGCCCAGCAAAGCAGACAACCCCCATCTGCTCACCATCCAGCC       GGACCTCAGCACCACCACCACCTACCAGGGCAGTCTCTGTCCCCGGCAGGATGGGCCCAGCCCCAAGT       TCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACACACTGCACCACAGCTCT       CCCACCTCTGAGGCCGAGGAGTTCGTCTCCCGCCTCTCCACCCAGAACTACTTCCGCTCCCTGCCCCG       AGGCACCAGCAACATGACCTATGGGACCTTCAACTTCCTCGGGGGCCGGCTGATGATCCCTAATACAG       GTATCAGCCTCCTCATCCCCCCAGATGCCATACCCCGAGGGAAGATCTATGAGATCTACCTCACGCTG       CACAAGCCGGAAGACGTGAGGTTGCCCCTAGCTGGCTGTCAGACCCTGCTGAGTCCCATCGTTAGCTG       CTGACAGCTGGAGCCTGCGCCTCAAAAAGCAGTCGTGCGAGGGCAGCTGGGAGCAGGATGTGCTGCAC       CTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCCTGCTACGTCTTCAC       CGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCGCCAAGCGCCTCAAGC       TGCTTCTGTTTGCGCCGGTGGCCTGCACCTCCCTCGAGTACAACATCCGGGTCTACTGCCTGCATGAC       ACCCACGATGCACTCAAGGAGGTGGTGCAGCTGGAGAAGCAGCTGGGGGGACAGCTGATCCAGGAGCC       ACGGGTCCTGCACTTCAAGGACAGTTACCACAACCTGCGCCTATCCATCCACGATGTGCCCAGCTCCC       TGTGGAAGAGTAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTTTATCACATCTGGAATGGCACGCAG       GTGGGTGTGGCAGGTGGAGGGCGACGGGCAGAGCTTCAGCATCAACTTCAACATCACCAAGGACACAA       GGTTTGCTGAGCTGCTGGCTCTGGAGAGTGAAGCGGGGGTCCCAGCCCTGGTGGGCCCCAGTGCCTTC       AAGATCCCCTTCCTCATTCGGCAGAAGATAATTTCCAGCCTGGACCCACCCTGTAGGCGGGGTGCCGA       CTGGCGGACTCTGGCCCAGAAACTCCACCTGGACAGCCATCTCAGCTTCTTTGCCTCCAAGCCCAGCC       CCACAGCCATGATCCTCAACCTGTGGGAGGCGCGGCACTTCCCCAACGGCAACCTCAGCCAGCTGGCT       GCAGCAGTGGCTGGACTGGGCCAGCCAGACGCTGGCCTCTTCACAGTGTCGGAGGCTGAGTGCTGAGG       CCGGCCAGGCCCGACACCTACACTCTCACCAGCTTTGGCACCCACCAAGGACAGGCAGAAGCCGGACA       GGGGCCCTTCCCCACACCGGGGAGA                                                 NOV21i, SNP13382444 of   SEQ ID NO: 522       MW at 98934.8kD                                 CG53908-01, Protein Sequence   SNP Pos: 112   898 aa   SNP Change: Gln to End                             MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV           PATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQVEKVFGLEEYWCQCVAWSSSGTTKS       QKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHS       LVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNPA       PLNGGAFCEGQNVHDRTVSSLLVSVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLD       TRNCTSDLCVHSASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVS       IKPSKADNPHLLTIQPDLSTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAEE       FVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVR       LPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEQDVLHLGEEAPS       HLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALKE       VVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPEYNIWNGTQRYLHCTF       TLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPELIR       QKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLG       QPDAGLFTVSEAEC                                                 SEQ ID NO: 523   2881 bp                                 NOV21j, SNP13375491 of   ORF Start: ATG at 87   ORF Stop: TGA at 2784                             CG53908-01, DNA Sequence   SNP Pos: 1139   SNP Change: A to G                             AGCTGGGGCTCCGGGCTGAGGCGCTAAAGCCGCCCTCCCGCCCGCGGGGCCCCGCGCCCGGCCCGCCC           GCCTGCCCGCCCGCGGCCATGGCCGTCCGGCCCGGCCTGTGGCCAGCGCTCCTGGGCATAGTCCTCGC       CGCTTGGCTCCGCGGCTCGGGTGCCCAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACC       CGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTG       CTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGT       TCTCAAGGCAGCAGGTCGAGAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGC       GGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCA       TCCCTCCAGCCGAGGTGGAGTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTA       CGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTG       GGTGGTCGACGTGGACCGAGTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGC       CGGAGCTGCACCAACCCGGCGCCTCTCAACGGGGGCGCTTTCTGTGAGGGGCAGAATGTCCATGACCG       CACCGTCTCCTCTCTGCTTGTCTCTGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTG       GGCTGGACTGCACCCACTGGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAG       TGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTGCACAGTGCTTCTGGCCC       TGAGGACGTGGCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCTGCCTGGTCCTGCTGCTGCTTGTCC       TCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCGTCCATTCTCACC       TCAGGCTTCCAGCCCGTCAGCATCAAGCCCAGCAAAGCAGACAACCCCCATCTGCTCACCATCCAGCC       GGACCTCAGCACCACCACCACCTACCAGGGCAGTCTCTGTCCCCGGCAGGATGGGCCCAGCCCCAAGT       TCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACACACTGCACCACAGCTCT       CCCACCTCTGAGGCCGAGGAGTTCGTCTCCCGCCTCTCCACCCAGAACTACTTCCGCTCCCTGCCCCG       AGGCACCAGCAACATGACCTATGGGACCTTCAACTTCCTCGGGGGCCGGCTGATGATCCCTAATACAG       GTATCAGCCTCCTCATCCCCCCAGATGCCATACCCCGAGGGAAGATCTATGAGATCTACCTCACGCTG       CACAAGCCGGAAGACGTGAGGTTGCCCCTAGCTGGCTGTCAGACCCTGCTGAGTCCCATCGTTAGCTG       TGGACCCCCTGGCGTCCTGCTCACCCGGCCAGTCATCCTGGCTATGGACCACTGTGGGGAGCCCAGCC       CTGACAGCTGGAGCCTGCGCCTCAAAAAGCAGTCGTGCGAGGGCAGCTGGGAGCAGGATGTGCTGCAC       CTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCCTGCTACGTCTTCAC       CGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCGCCAAGCGCCTCAAGC       TGCTTCTGTTTGCGCCGGTGGCCTGCACCTCCCTCGAGTACAACATCCGGGTCTACTGCCTGCATGAC       ACCCACGATGCACTCAAGGAGGTGGTGCAGCTGGAGAAGCAGCTGGGGGGACAGCTGATCCAGGAGCC       ACGGGTCCTGCACTTCAAGGACAGTTACCACAACCTGCGCCTATCCATCCACGATGTGCCCAGCTCCC       TGTGGAAGAGTAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTTTATCACATCTGGAATGGCACGCAG       CGGTACTTGCACTGCACCTTCACCCTGGAGCGTGTCAGCCCCAGCACTAGTGACCTGGCCTGCAAGCT       GGTTTGCTGAGCTGCTGGCTCTGGAGAGTGAAGCGGGGGTCCCAGCCCTGGTGGGCCCCAGTGCCTTC       AAGATCCCCTTCCTCATTCGGCAGAAGATAATTTCCAGCCTGGACCCACCCTGTAGGCGGGGTGCCGA       CTGGCGGACTCTGGCCCAGAAACTCCACCTGGACAGCCATCTCAGCTTCTTTGCCTCCAAGCCCAGCC       CCACAGCCATGATCCTCAACCTGTGGGAGGCGCGGCACTTCCCCAACGGCAACCTCAGCCAGCTGGCT       GCAGCAGTGGCTGGACTGGGCCAGCCAGACGCTGGCCTCTTCACAGTGTCGGAGGCTGAGTGCTGAGG       CCGGCCAGGCCCGACACCTACACTCTCACCAGCTTTGGCACCCACCAAGGACAGGCAGAAGCCGGACA       GGGGCCCTTCCCCACACCGGGGAGA                                                 NOV21j, SNP13375491 of   SEQ ID NO: 524       MW at 99063.0kD                                 CG53908-01, Protein Sequence   SNP Pos: 351   899 aa   SNP Change: Val to Val                             MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV           PATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTK       SQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH       SLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNP       APLNGGAFCEGQNVHDRTVSSLLVSVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDL       DTRNCTSDLCVHSASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPV       SIKPSKADNPHLLTIQPDLSTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE       EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDV       RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEQDVLHLGEEAP       SHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALK       EVVQLEKQLGGQLIQEPRVLHFKDSYHNLRISIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCT       FTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPELI       RQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGL       GQPDAGLFTVSEAEC                                                 SEQ ID NO: 525   2881 bp                                 NOV21k, SNP13375492 of   ORF Start: ATG at 87   ORF Stop: TGA at 2784                             CG53908-01, DNA Sequence   SNP Pos: 1225   SNP Change: T to C                             AGCTGGGGCTCCGGGCTGAGGCGCTAAAGCCGCCCTCCCGCCCGCGGGGCCCCGCGCCCGGCCCGCCC           GCCTGCCCGCCCGCGGCCATGGCCGTCCGGCCCGGCCTGTGGCCAGCGCTCCTGGGCATAGTCCTCGC       CGCTTGGCTCCGCGGCTCGGGTGCCCAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACC       CGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTG       CTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGT       GGACCACGTGATCGAGCGCAGCACAGACGGGAGCAGTGGTGAGCCGACCATGGAGGTCCGCATTAATG       TCTCAAGGCAGCAGGTCGAGAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGC       TCCTCGGGCACCACCAAGAGTCAGAAGGCCTACATCCGCATAGCCAGATTGCGCAAGAACTTCGAGCA       GGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCA       TCCCTCCAGCCGAGGTGGAGTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTA       TACATCACGCGGGAGCACAGCCTGGTGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTG       CGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTG       GGTGGTCGACGTGGACCGAGTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGC       CGGAGCTGCACCAACCCGGCGCCTCTCAACGGGGGCGCTTTCTGTGAGGGGCAGAATGTCCATGACCG       CACCGTCTCCTCTCTGCTTGTCTCTGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTG       GGCTGGACTGCACCCACTGGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAG       TGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTACACAGTGCTTCTGGCCC       TGAGGACGTGGCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCTGCCTGGTCCTGCTGCTGCTTGTCC       CCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCGTCCATTCTCACC       TCAGGCTTCCAGCCCGTCAGCATCAAGCCCAGCAAAGCAGACAACCCCCATCTGCTCACCATCCAGCC       GGACCTCAGCACCACCACCACCTACCAGGGCAGTCTCTGTCCCCGGCAGGATGGGCCCAGCCCCAAGT       TCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACACACTGCACCACAGCTCT       CCCACCTCTGAGGCCGAGGAGTTCGTCTCCCGCCTCTCCACCCAGAACTACTTCCGCTCCCTGCCCCG       GTATCAGCCTCCTCATCCCCCCAGATGCCATACCCCGAGGGAAGATCTATGAGATCTACCTCACGCTG       CACAAGCCGGAAGACGTGAGGTTGCCCCTAGCTGGCTGTCAGACCCTGCTGAGTCCCATCGTTAGCTG       TGGACCCCCTGGCGTCCTGCTCACCCGGCCAGTCATCCTGGCTATGGACCACTGTGGGGAGCCCAGCC       CTGACAGCTGGAGCCTGCGCCTCAAAAAGCAGTCGTGCGAGGGCAGCTGGGAGCAGGATGTGCTGCAC       CTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCCTGCTACGTCTTCAC       CGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCGCCAAGCGCCTCAAGC       TGCTTCTGTTTGCGCCGGTGGCCTGCACCTCCCTCGAGTACAACATCCGGGTCTACTGCCTGCATGAC       ACCCACGATGCACTCAAGGAGGTGGTGCAGCTGGAGAAGCAGCTGGGGGGACAGCTGATCCAGGAGCC       ACGGGTCCTGCACTTCAAGGACAGTTACCACAACCTGCGCCTATCCATCCACGATGTGCCCAGCTCCC       TGTGGAAGAGTAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTTTATCACATCTGGAATGGCACGCAG       CGGTACTTGCACTGCACCTTCACCCTGGAGCGTGTCAGCCCCAGCACTAGTGACCTGGCCTGCAAGCT       GTGGGTGTGGCAGGTGGAGGGCGACGGGCAGAGCTTCAGCATCAACTTCAACATCACCAAGGACACAA       GGTTTGCTGAGCTGCTGGCTCTGGAGAGTGAAGCGGGGGTCCCAGCCCTGGTGGGCCCCAGTGCCTTC       AAGATCCCCTTCCTCATTCGGCAGAAGATAATTTCCAGCCTGGACCCACCCTGTAGGCGGGGTGCCGA       CCACAGCCATGATCCTCAACCTGTGGGAGGCGCGGCACTTCCCCAACGGCAACCTCAGCCAGCTGGCT       GCAGCAGTGGCTGGACTGGGCCAGCCAGACGCTGGCCTCTTCACAGTGTCGGAGGCTGAGTGCTGAGG       GGGGCCCTTCCCCACACCGGGGAGA                                                 NOV21k, SNP13375492 of   SEQ ID NO: 526       MW at 99046.9kD                                 CG53908-1, Protein Sequence   SNP Pos: 380   899 aa   SNP Change: Leu to Pro                             MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV           PATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTK       SQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH       SLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNP       APLNGGAFCEGQNVHDRTVSSLLVSVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDL       DTRNCTSDLCVHSASGPEDVALYVGLIAVAVCLVLLLLVPILVYCRKKEGLDSDVADSSILTSGFQPV       SIKPSKADNPHLLTIQPDLSTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE       EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDV       RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEQDVLHLGEEAP       SHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNTRVYCLHDTHDALK       EVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCT       FTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLI       RQKIISSLDPPCRRGADWRTLLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGL       GQPDAGLFTVSEAEC                                                 SEQ ID NO: 527   2881 bp                                 NOV21l, SNP13375493 of   ORF Start: ATG at 87   ORF Stop: TGA at 2784                             CG53908-01, DNA Sequence   SNP Pos: 1660   SNP Change: C to T                             AGCTGGGGCTCCGGGCTGAGGCGCTAAAGCCGCCCTCCCGCCCGCGGGGCCCCGCGCCCGGCCCGCCC           GCCTGCCCGCCCGCGGCCATGGCCGTCCGGCCCGGCCTGTGGCCAGCGCTCCTGGGCATAGTCCTCGC       CGCTTGGCTCCGCGGCTCGGGTGCCCAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACC       CGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTG       CTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGT       GGACCACGTGATCGAGCGCAGCACAGACGGGAGCAGTGGTGAGCCGACCATGGAGGTCCGCATTAATG       TCTCAAGGCAGCAGGTCGAGAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGC       TCCTCGGGCACCACCAAGAGTCAGAAGGCCTACATCCGCATAGCCAGATTGCGCAAGAACTTCGAGCA       GGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCA       TCCCTCCAGCCGAGGTGGAGTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTA       TACATCACGCGGGAGCACAGCCTGGTGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTG       CGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTG       GGTGGTCGACGTGGACCGAGTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGC       CGGAGCTGCACCAACCCGGCGCCTCTCAACGGGGGCGCTTTCTGTGAGGGGCAGAATGTCCATGACCG       CACCGTCTCCTCTCTGCTTGTCTCTGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTG       GGCTGGACTGCACCCACTGGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAG       TGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTACACAGTGCTTCTGGCCC       TGAGGACGTGGCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCTGCCTGGTCCTGCTGCTGCTTGTCC       TCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCGTCCATTCTCACC       GGACCTCAGCACCACCACCACCTACCAGGGCAGTCTCTGTCCCCGGCAGGATGGGCCCAGCCCCAAGT       TCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACACACTGCACCACAGCTCT       GTATCAGCCTCCTCATCCCCCCAGATGTCATACCCCGAGGGAAGATCTATGAGATCTACCTCACGCTG       CACAAGCCGGAAGACGTGAGGTTGCCCCTAGCTGGCTGTCAGACCCTGCTGAGTCCCATCGTTAGCTG       TGGACCCCCTGGCGTCCTGCTCACCCGGCCAGTCATCCTGGCTATGGACCACTGTGGGGAGCCCAGCC       CTGACAGCTGGAGCCTGCGCCTCAAAAAGCAGTCGTGCGAGGGCAGCTGGGAGCAGGATGTGCTGCAC       CTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCCTGCTACGTCTTCAC       CGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCGCCAAGCGCCTCAAGC       TGCTTCTGTTTGCGCCGGTGGCCTGCACCTCCCTCGAGTACAACATCCGGGTCTACTGCCTGCATGAC       ACCCACGATGCACTCAAGGAGGTGGTGCAGCTGGAGAAGCAGCTGGGGGGACAGCTGATCCAGGAGCC       ACGGGTCCTGCACTTCAAGGACAGTTACCACAACCTGCGCCTATCCATCCACGATGTGCCCAGCTCCC       TGTGGAAGAGTAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTTTATCACATCTGGAATGGCACGCAG       CGGTACTTGCACTGCACCTTCACCCTGGAGCGTGTCAGCCCCAGCACTAGTGACCTGGCCTGCAAGCT       GTGGGTGTGGCAGGTGGAGGGCGACGGGCAGAGCTTCAGCATCAACTTCAACATCACCAAGGACACAA       GGTTTGCTGAGCTGCTGGCTCTGGAGAGTGAAGCGGGGGTCCCAGCCCTGGTGGGCCCCAGTGCCTTC       AAGATCCCCTTCCTCATTCGGCAGAAGATAATTTCCAGCCTGGACCCACCCTGTAGGCGGGGTGCCGA       CCACAGCCATGATCCTCAACCTGTGGGAGGCGCGGCACTTCCCCAACGGCAACCTCAGCCAGCTGGCT       GCAGCAGTGGCTGGACTGGGCCAGCCAGACGCTGGCCTCTTCACAGTGTCGGAGGCTGAGTGCTGAGG       CCGGCCAGGCCCGACACCTACACTCTCACCAGCTTTGGCACCCACCAAGGACAGGCAGAAGCCGGACA       GGGGCCCTTCCCCACACCGGGGAGA                                                 NOV21l, SNP13375493 of   SEQ ID NO: 528       MW at 99091.0kD                                 CG53908-01, Protein Sequence   SNP Pos: 525   899 aa   SNP Change: Ala to Val                             MARRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV           PATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTK       SQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH       SLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNP       APLNGGAFCEGQNVHDRTVSSLLVSVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDL       DTRNCTSDLCVHSASGPEDVALYVGLIAVAVCLVLLLLVILVYCRKKEGLDSDVADSSILTSGFQPV       SIKPSKADNPHLLTIQPDLSTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE       EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDVIPRGKIYEIYLTLHKPEDV       RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEQDVLHLGEEAP       SHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALK       EVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCT       FTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKTPFLI       RQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGL       GQPDAGLFTVSEAEC                                                 SEQ ID NO: 529   2881 bp                                 NOV21m, SNP13375135 of   ORF Start: ATG at 87   ORF Stop: TGA at 2784                             CG53908-01, DNA Sequence   SNP Pos: 1855   SNP Change: G to A                             AGCTGGGGCTCCGGGCTGAGGCGCTAAAGCCGCCCTCCCGCCCGCGGGGCCCCGCGCCCGGCCCGCCC           GCCTGCCCGCCCGCGGCCATGGCCGTCCGGCCCGGCCTGTGGCCAGCGCTCCTGGGCATAGTCCTCGC       CGCTTGGCTCCGCGGCTCGGGTGCCCAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACC       CGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTG       CTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGT       GGACCACGTGATCGAGCGCAGCACAGACGGGAGCAGTGGTGAGCCGACCATGGAGGTCCGCATTAATG       TCTCAAGGCAGCAGGTCGAGAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGC       TCCTCGGGCACCACCAAGAGTCAGAAGGCCTACATCCGCATAGCCAGATTGCGCAAGAACTTCGAGCA       GGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCA       TACATCACGCGGGAGCACAGCCTGGTGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTG       CGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTG       GGTGGTCGACGTGGACCGAGTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGC       CACCGTCTCCTCTCTGCTTGTCTCTGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTG       TGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTACACAGTGCTTCTGGCCC       TGAGGACGTGGCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCTGCCTGGTCCTGCTGCTGCTTGTCC       TCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCGTCCATTCTCACC       TCAGGCTTCCAGCCCGTCAGCATCAAGCCCAGCAAAGCAGACAACCCCCATCTGCTCACCATCCAGCC       GGACCTCAGCACCACCACCACCTACCAGGGCAGTCTCTGTCCCCGGCAGGATGGGCCCAGCCCCAAGT       TCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACACACTGCACCACAGCTCT       CCCACCTCTGAGGCCGAGGAGTTCGTCTCCCGCCTCTCCACCCAGAACTACTTCCGCTCCCTGCCCCG       AGGCACCAGCAACATGACCTATGGGACCTTCAACTTCCTCGGGGGCCGGCTGATGATCCCTAATACAG       GTATCAGCCTCCTCATCCCCCCAGATGCCATACCCCGAGGGAAGATCTATGAGATCTACCTCACGCTG       CACAAGCCGGAAGACGTGAGGTTGCCCCTAGCTGGCTGTCAGACCCTGCTGAGTCCCATCGTTAGCTG       TGGACCCCCTGGCGTCCTGCTCACCCGGCCAGTCATCCTGGCTATGGACCACTGTGGGGAGCCCAGCC       CTGACAGCTGGAGCCTGCACCTCAAAAAGCAGTCGTGCGAGGGCAGCTGGGAGCAGGATGTGCTGCAC       CTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCCTGCTACGTCTTCAC       CGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCGCCAAGCGCCTCAAGC       TGCTTCTGTTTGCGCCGGTGGCCTGCACCTCCCTCGAGTACAACATCCGGGTCTACTGCCTGCATGAC       ACCCACGATGCACTCAAGGAGGTGGTGCAGCTGGAGAAGCAGCTGGGGGGACAGCTGATCCAGGAGCC       ACGGGTCCTGCACTTCAAGGACAGTTACCACAACCTGCGCCTATCCATCCACGATGTGCCCAGCTCCC       TGTGGAAGAGTAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTTTATCACATCTGGAATGGCACGCAG       CGGTACTTGCACTGCACCTTCACCCTGGAGCGTGTCAGCCCCAGCACTAGTGACCTGGCCTGCAAGCT       GTGGGTGTGGCAGGTGGAGGGCGACGGGCAGAGCTTCAGCATCAACTTCAACATCACCAAGGACACAA       GGTTTGCTGAGCTGCTGGCTCTGGAGAGTGAAGCGGGGGTCCCAGCCCTGGTGGGCCCCAGTGCCTTC       AAGATCCCCTTCCTCATTCGGCAGAAGATAATTTCCAGCCTGGACCCACCCTGTAGGCGGGGTGCCGA       CTGGCGGACTCTGGCCCAGAAACTCCACCTGGACAGCCATCTCAGCTTCTTTGCCTCCAAGCCCAGCC       CCACAGCCATGATCCTCAACCTGTGGGAGGCGCGGCACTTCCCCAACGGCAACCTCAGCCAGCTGGCT       GCAGCAGTGGCTGGACTGGGCCAGCCAGACGCTGGCCTCTTCACAGTGTCGGAGGCTGAGTGCTGAGG       CCGGCCAGGCCCGACACCTACACTCTCACCAGCTTTGGCACCCACCAAGGACAGGCAGAAGCCGGACT       GGGGCCCTTCCCCACACCGGGGAGA                                                 NOV21m, SNP13375135 of   SEQ ID NO:530       MW at 99043.9kD                                 CG53908-01, Protein Sequence   SNP Pos: 590   899 aa   SNP Change: Arg to His                             MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV           PATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTK       SQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH       SLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNP       APLNGGAFCEGQNVHDRTVSSLLVSVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDL       DTRNCTSDLCHSASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVPINSSILTSGFQPV       SIKPSKADNPHLLTIQPDLSTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE       EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDV       RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLHLKKQSCEGSWEQDVLHLGEEAP       SHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALK       EVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCT       FTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLI       RQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGL       GQPDAGLFTVSEAEC                                                 SEQ ID NO: 531   2881 bp                                 NOV21n, SNP13375136 of   ORF Start: ATG at 87   ORF Stop: TGA at 2784                             CG53908-01, DNA Sequence   SNP Pos: 1965   SNP Change: G to A                             AGCTGGGGCTCCGGGCTGAGGCGCTAAAGCCGCCCTCCCGCCCGCGGGGCCCCGCGCCCGGCCCGCCC           CGCTTGGCTCCGCGGCTCGGGTGCCCAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACC       CGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTG       CTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGT       GGACCACGTGATCGAGCGCAGCACAGACGGGAGCAGTGGTGAGCCGACCATGGAGGTCCGCATTAATG       TCTCAAGGCAGCAGGTCGAGAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGC       TCCTCGGGCACCACCAAGAGTCAGAAGGCCTACATCCGCATAGCCAGATTGCGCAAGAACTTCGAGCA       GGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCA       TCCCTCCAGCCGAGGTGGAGTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTA       TACATCACGCGGGAGCACAGCCTGGTGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTG       CGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTG       GGTGGTCGACGTGGACCGAGTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGC       CGGAGCTGCACCAACCCGGCGCCTCTCAACGGGGGCGCTTTCTGTGAGGGGCAGAATGTCCATGACCG       CACCGTCTCCTCTCTGCTTGTCTCTGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTG       GGCTGGACTGCACCCACTGGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAG       TGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTACACAGTGCTTCTGGCCC       TGAGGACGTGGCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCTGCCTGGTCCTGCTGCTGCTTGTCC       TCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCGTCCATTCTCACC       TCAGGCTTCCAGCCCGTCAGCATCAAGCCCAGCAAAGCAGACAACCCCCATCTGCTCACCATCCAGCC       GGACCTCAGCACCACCACCACCTACCAGGGCAGTCTCTGTCCCCGGCAGGATGGGCCCAGCCCCAAGT       TCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACACACTGCACCACAGCTCT       CCCACCTCTGAGGCCGAGGAGTTCGTCTCCCGCCTCTCCACCCAGAACTACTTCCGCTCCCTGCCCCG       AGGCACCAGCAACATGACCTATGGGACCTTCAACTTCCTCGGGGGCCGGCTGATGATCCCTAATACAG       CACAAGCCGGAAGACGTGAGGTTGCCCCTAGCTGGCTGTCAGACCCTGCTGAGTCCCATCGTTAGCTG       TGGACCCCCTGGCGTCCTGCTCACCCGGCCAGTCATCCTGGCTATGGACCACTGTGGGGAGCCCAGCC       CTGACAGCTGGAGCCTGCGCCTCAAAAAGCAGTCGTGCGAGGGCAGCTGGGAGCAGGATGTGCTGCAC       CTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCCTGCTACATCTTCAC       CGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCGCCAAGCGCCTCAAGC       ACCCACGATGCACTCAAGGAGGTGGTGCAGCTGGAGAAGCAGCTGGGGGGACAGCTGATCCAGGAGCC       TGTGGAAGAGTAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTTTATCACATCTGGAATGGCACGCAG       CGGTACTTGCACTGCACCTTCACCCTGGAGCGTGTCAGCCCCAGCACTAGTGACCTGGCCTGCAAGCT       GTGGGTGTGGCAGGTGGAGGGCGACGGGCAGAGCTTCAGCATCAACTTCAACATCACCAAGGACACAA       GGTTTGCTGAGCTGCTGGCTCTGGAGAGTGAAGCGGGGGTCCCAGCCCTGGTGGGCCCCAGTGCCTTC       AAGATCCCCTTCCTCATTCGGCAGAAGATAATTTCCAGCCTGGACCCACCCTGTAGGCGGGGTGCCGA       CTGGCGGACTCTGGCCCAGAAACTCCACCTGGACAGCCATCTCAGCTTCTTTGCCTCCAAGCCCAGCC       CCACAGCCATGATCCTCAACCTGTGGGAGGCGCGGCACTTCCCCAACGGCAACCTCAGCCAGCTGGCT       GCAGCAGTGGCTGGACTGGGCCAGCCAGACGCTGGCCTCTTCACAGTGTCGGAGGCTGAGTGCTGAGG       CCGGCCAGGCCCGACACCTACACTCTCACCAGCTTTGGCACCCACCAAGGACAGGCAGAAGCCGGACA       GGGGCCCTTCCCCACACCGGGGAGA                                                 NOV21n, SNP13375136 of   SEQ ID NO: 532       MW at 99077.0kD                                 CG53908-01, Protein Sequence   SNP Pos: 627   899 aa   SNP Change: Val to Ile                             +TL,1, MARVPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV           PATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTK       SQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH       DTRNCTSDLCVHSASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPV       SIKPSKADNPHLLTIQPDLSTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE       EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDV       RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKYQSCEGSWEQDVLHLGEEAP       SHLYYCQLEASACYIFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALK       EVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCT       FTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLI       RQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGL       GQPDAGLFTVSEAEC                                                 SEQ ID NO: 533   2881 bp                                 NOV21o, SNP13375137 of   ORF Start: ATG at 87   ORF Stop: TGA at 2784                             CG53908-01, DNA Sequence   SNP Pos: 2025   SNP Change: G to A                             AGCTGGGGCTCCGGGCTGAGGCGCTAAAGCCGCCCTCCCGCCCGCGGGGCCCCGCGCCCGGCCCGCCC           GCCTGCCCGCCCGCGGCCATGGCCGTCCGGCCCGGCCTGTGGCCAGCGCTCCTGGGCATAGTCCTCGC       CGCTTGGCTCCGCGGCTCGGGTGCCCAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACC       CGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTG       CTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGT       GGACCACGTGATCGAGCGCAGCACAGACGGGAGCAGTGGTGAGCCGACCATGGAGGTCCGCATTAATG       TCTCAAGGCAGCAGGTCGAGAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGC       TCCTCGGGCACCACCAAGAGTCAGAAGGCCTACATCCGCATAGCCAGATTGCGCAAGAACTTCGAGCA       GGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCA       TCCCTCCAGCCGAGGTGGAGTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTA       TACATCACGCGGGAGCACAGCCTGGTGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTG       CGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTG       GGTGGTCGACGTGGACCGAGTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGC       CGGAGCTGCACCAACCCGGCGCCTCTCAACGGGGGCGCTTTCTGTGAGGGGCAGAATGTCCATGACCG       CACCGTCTCCTCTCTGCTTGTCTCTGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTG       GGCTGGACTGCACCCACTGGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAG       TGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTACACAGTGCTTCTGGCCC       TGAGGACGTGGCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCTGCCTGGTCCTGCTGCTGCTTGTCC       TCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCGTCCATTCTCACC       TCAGGCTTCCAGCCCGTCAGCATCAAGCCCAGCAAAGCAGACAACCCCCATCTGCTCACCATCCAGCC       GGACCTCAGCACCACCACCACCTACCAGGGCAGTCTCTGTCCCCGGCAGGATGGGCCCAGCCCCAAGT       TCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACACACTGCACCACAGCTCT       CCCACCTCTGAGGCCGAGGAGTTCGTCTCCCGCCTCTCCACCCAGAACTACTTCCGCTCCCTGCCCCG       AGGCACCAGCAACATGACCTATGGGACCTTCAACTTCCTCGGGGGCCGGCTGATGATCCCTAATACAG       GTATCAGCCTCCTCATCCCCCCAGATGCCATACCCCGAGGGAAGATCTATGAGATCTACCTCACGCTG       TGGACCCCCTGGCGTCCTGCTCACCCGGCCAGTCATCCTGGCTATGGACCACTGTGGGGAGCCCAGCC       CTGACAGCTGGAGCCTGCGCCTCAAAAAGCAGTCGTGCGAGGGCAGCTGGGAGCAGGATGTGCTGCAC       CTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCCTGCTACGTCTTCAC       CGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCACCAAGCGCCTCAAGC       TGCTTCTGTTTGCGCCGGTGGCCTGCACCTCCCTCGAGTACAACATCCGGGTCTACTGCCTGCATGAC       ACCCACGATGCACTCAAGGAGGTGGTGCAGCTGGAGAAGCAGCTGGGGGGACAGCTGATCCAGGAGCC       ACGGGTCCTGCACTTCAAGGACAGTTACCACAACCTGCGCCTATCCATCCACGATGTGCCCAGCTCCC       TGTGGAAGAGTAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTTTATCACATCTGGAATGGCACGCAG       CGGTACTTGCACTGCACCTTCACCCTGGAGCGTGTCAGCCCCAGCACTAGTGACCTGGCCTGCAAGCT       GTGGGTGTGGCAGGTGGAGGGCGACGGGCAGAGCTTCAGCATCAACTTCAACATCACCAAGGACACAA       GGTTTGCTGAGCTGCTGGCTCTGGAGAGTGAAGCGGGGGTCCCAGCCCTGGTGGGCCCCAGTGCCTTC       AAGATCCCCTTCCTCATTCGGCAGAAGATAATTTCCAGCCTGGACCCACCCTGTAGGCGGGGTGCCGA       CTGGCGGACTCTGGCCCAGAAACTCCACCTGGACAGCCATCTCAGCTTCTTTGCCTCCAAGCCCAGCC       CCACAGCCATGATCCTCAACCTGTGGGAGGCGCGGCACTTCCCCAACGGCAACCTCAGCCAGCTGGCT       GCAGCAGTGGCTGGACTGGGCCAGCCAGACGCTGGCCTCTTCACAGTGTCGGAGGCTGAGTGCTGAGG       CCGGCCAGGCCCGACACCTACACTCTCACCAGCTTTGGCACCCACCAAGGACAGGCAGAAGCCGGACA       GGGGCCCTTCCCCACACCGCGGAGA                                                 NOV21o, SNP13375137 of   SEQ ID NO: 534       MW at 99093.0kD                                 CG53908-01, Protein Sequence   SNP Pos: 647   899 aa   SNP Change: Ala to Thr                             MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV           PATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTK       SQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH       SLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNP       APLNGGAFCEGQNVHDRTVSSLLVSVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDL       DTRNCTSDLCVHSASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPV       SIKPSKADNPHLLTIQPDLSTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE       EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGPLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDV       RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEQDVLHLGEEAP       SHLYYCQLEASACYVFTEQLGRFALVGEALSVAATKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALK       EVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCT       FTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLI       RQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGL       GQPDAGLFTVSEAEC                                                 SEQ ID NO: 535   2881 bp                                 NOV21p, SNP13375138 of   ORF Start: ATG at 87   ORF Stop: TGA at 2784                             CG53908-01, DNA Sequence   SNP Pos: 2038   SNP Change: A to G                             AGCTGGGGCTCCGGGCTGAGGCGCTAAAGCCGCCCTCCCGCCCGCGGGGCCCCGCGCCCGGCCCGCCC           GCCTGCCCGCCCGCGGCCATGGCCGTCCGGCCCGGCCTGTGGCCAGCGCTCCTGGGCATAGTCCTCGC       CGCTTGGCTCCGCGGCTCGGGTGCCCAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACC       CGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTG       CTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGT       GGACCACGTGATCGAGCGCAGCACAGACGGGAGCAGTGGTGAGCCGACCATGGAGGTCCGCATTAATG       TCTCAAGGCAGCAGGTCGAGAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGC       TCCTCGGGCACCACCAAGAGTCAGAAGGCCTACATCCGCATAGCCAGATTGCGCAAGAACTTCGAGCA       GGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCA       TCCCTCCAGCCGAGGTGGAGTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTA       CGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTG       GGTGGTCGACGTGGACCGAGTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGC       CGGAGCTGCACCAACCCGGCGCCTCTCAACGGGGGCGCTTTCTGTGAGGGGCAGAATGTCCATGACCG       CACCGTCTCCTCTCTGCTTGTCTCTGTGGACGGCAGCTGGAGCCCGTGGAGCCCGTGGTCGGCCTGTG       GGCTGGACTGCACCCACTGGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAG       TGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTACACAGTGCTTCTGGCCC       TGAGGACGTGGCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCTGCCTGGTCCTGCTGCTGCTTGTCC       TCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCGTCCATTCTCACC       TCAGGCTTCCAGCCCGTCAGCATCAAGCCCAGCAAAGCAGACAACCCCCATCTGCTCACCATCCAGCC       GGACCTCAGCACCACCACCACCTACCAGGGCAGTCTCTGTCCCCGGCAGGATGGGCCCAGCCCCAAGT       TCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACACACTGCACCACAGCTCT       CCCACCTCTGAGGCCGAGGAGTTCGTCTCCCGCCTCTCCACCCAGAACTACTTCCGCTCCCTGCCCCG       AGGCACCAGCAACATGACCTATGGGACCTTCAACTTCCTCGGGGGCCGGCTGATGATCCCTAATACAG       GTATCAGCCTCCTCATCCCCCCAGATGCCATACCCCGAGGGAAGATCTATGAGATCTACCTCACGCTG       CACAAGCCGGAAGACGTGAGGTTGCCCCTAGCTGGCTGTCAGACCCTGCTGAGTCCCATCGTTAGCTG       TGGACCCCCTGGCGTCCTGCTCACCCGGCCAGTCATCCTGGCTATGGACCACTGTGGGGAGCCCAGCC       CTGACAGCTGGAGCCTGCGCCTCAAAAAGCAGTCGTGCGAGGGCAGCTGGGAGCAGGATGTGCTGCAC       CTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCCTGCTACGTCTTCAC       CGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCGCCAAGCGCCTCAGGC       TGCTTCTGTTTGCGCCGGTGGCCTGCACCTCCCTCGAGTACAACATCCGGGTCTACTGCCTGCATGAC       ACCCACGATGCACTCAAGGAGGTGGTGCAGCTGGAGAAGCAGCTGGGGGGACAGCTGATCCAGGAGCC       ACGGGTCCTGCACTTCAAGGACAGTTACCACAACCTGCGCCTATCCATCCACGATGTGCCCAGCTCCC       TGTGGAAGAGTAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTTTATCACATCTGGAATGGCACGCAG       CGGTACTTGCACTGCACCTTCACCCTGGAGCGTGTCAGCCCCAGCACTAGTGACCTGGCCTGCAAGCT       GTGGGTGTGGCAGGTGGAGGGCGACGGGCAGAGCTTCAGCATCAACTTCAACATCACCAAGGACACAA       AAGATCCCCTTCCTCATTCGGCAGAAGATAATTTCCAGCCTGGACCCACCCTGTAGGCGGGGTGCCGA       CTGGCGGACTCTGGCCCAGAAACTCCACCTGGACAGCCATCTCAGCTTCTTTGCCTCCAAGCCCAGCC       CCACAGCCATGATCCTCAACCTGTGGGAGGCGCGGCACTTCCCCAACGGCAACCTCAGCCAGCTGGCT       GCAGCAGTGGCTGGACTGGGCCAGCCAGACGCTGGCCTCTTCACAGTGTCGGAGGCTGAGTGCTGAGG       CCGGCCAGGCCCGACACCTACACTCTCACCAGCTTTGGCACCCACCAAGGACAGGCAGAAGCCGGACA       GGGGCCCTTCCCCACACCGGGGAGA                                                 NOV21p, SNP13375138 of   SEQ ID NO: 536       MW at 99091.0kD                                 CG53908-01, Protein Sequence   SNP Pos: 651   899 aa   SNP Change: Lys to Arg                             MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV           PATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTK       SQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH       SLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNP       APLNGGAFCEGQNVHDRTVSSLLVSVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDL       DTPNCTSDLCVHSASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPV       SIKPSKADNPHLLTIQPDLSTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE       EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDV       RLPLAGCQTLLSPIVSCGPPGVLLTRPVIIAMDHCGEPSPDSWSLRLKKQSCEGSWEQDVLHLGEEAP       SHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLRLLLFAPVACTSLEYNIRVYCLHDTHDALK       EVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCT       FTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLI       RQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGL       GQPDAGLFTVSEAEC                                                 SEQ ID NO: 537   2881 bp                                 NOV21q, SNP13375494 of   ORF Start: ATG at 87   ORF Stop: TGA at 2784                             CG53908-01, DNA Sequence   SNP Pos: 2130   SNP Change: G to C                             AGCTGGGGCTCCGGGCTGAGGCGCTAAAGCCGCCCTCCCGCCCGCGGGGCCCCGCGCCCGGCCCGCCC           GCCTGCCCGCCCGCGGCCATGGCCGTCCGGCCCGGCCTGTGGCCAGCGCTCCTGGGCATAGTCCTCGC       CGCTTGGCTCCGCGGCTCGGGTGCCCAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACC       CGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTG       CTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGT       GGACCACGTGATCGAGCGCAGCACAGACGGGAGCAGTGGTGAGCCGACCATGGAGGTCCGCATTAATG       TCTCAAGGCAGCAGGTCGAGAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGC       TCCTCGGGCACCACCAAGAGTCAGAAGGCCTACATCCGCATAGCCAGATTGCGCAAGAACTTCGAGCA       GGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCA       TCCCTCCAGCCGAGGTGGAGTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTA       TACATCACGCGGGAGCACAGCCTGGTGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTG       CGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTG       GGTGGTCGACGTGGACCGAGTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGC       CGGAGCTGCACCAACCCGGCGCCTCTCAACGGGGGCGCTTTCTGTGAGGGGCAGAATGTCCATGACCG       CACCGTCTCCTCTCTGCTTGTCTCTGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTG       GGCTGGACTGCACCCACTGGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAG       TGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTACACAGTGCTTCTGGCCC       TGAGGACGTGGCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCTGCCTGGTCCTGCTGCTGCTTGTCC       TCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCGTCCATTCTCACC       TCAGGCTTCCAGCCCGTCAGCATCAAGCCCAGCAAAGCAGACAACCCCCATCTGCTCACCATCCAGCC       GGACCTCAGCACCACCACCACCTACCAGGGCAGTCTCTGTCCCCGGCAGGATGGGCCCAGCCCCAAGT       TCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACACACTGCACCACAGCTCT       AGGCACCAGCAACATGACCTATGGGACCTTCAACTTCCTCGGGGGCCGGCTGATGATCCCTAATACAG       CACAAGCCGGAAGACGTGAGGTTGCCCCTAGCTGGCTGTCAGACCCTGCTGAGTCCCATCGTTAGCTG       TGGACCCCCTGGCGTCCTGCTCACCCGGCCAGTCATCCTGGCTATGGACCACTGTGGGGAGCCCAGCC       CTGACAGCTGGAGCCTGCGCCTCAAAAAGCAGTCGTGCGAGGGCAGCTGGGAGCAGGATGTGCTGCAC       CTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCCTGCTACGTCTTCAC       CGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCGCCAAGCGCCTCAAGC       TGCTTCTGTTTGCGCCGGTGGCCTGCACCTCCCTCGAGTACAACATCCGGGTCTACTGCCTGCATGAC       ACCCACGATGCACTCAAGGAGCTGGTGCAGCTGGAGAAGCAGCTGGGGGGACAGCTGATCCAGGAGCC       ACGGGTCCTGCACTTCAAGGACAGTTACCACAACCTGCGCCTATCCATCCACGATGTGCCCAGCTCCC       CGGTACTTGCACTGCACCTTCACCCTGGAGCGTGTCAGCCCCAGCACTAGTGACCTGGCCTGCAAGCT       GTGGGTGTGGCAGGTGGAGGGCGACGGGCAGAGCTTCAGCATCAACTTCAACATCACCAAGGACACAA       GGTTTGCTGAGCTGCTGGCTCTGGAGAGTGAAGCGGGGGTCCCAGCCCTGGTGGGCCCCAGTGCCTTC       AAGATCCCCTTCCTCATTCGGCAGAAGATAATTTCCAGCCTGGACCCACCCTGTAGGCGGGGTGCCGA       CTGGCGGACTCTGGCCCAGAAACTCCACCTGGACAGCCATCTCAGCTTCTTTGCCTCCAAGCCCAGCC       CCACAGCCATGATCCTCAACCTGTGGGAGGCGCGGCACTTCCCCAACGGCAACCTCAGCCAGCTGGCT       GCAGCAGTGGCTGGACTGGGCCAGCCAGACGCTGGCCTCTTCACAGTGTCGGAGGCTGAGTGCTGAGG       CCGGCCAGGCCCGACACCTACACTCTCACCAGCTTTGGCACCCACCAAGGACAGGCAGAAGCCGGACA       GGGGCCCTTCCCCACACCGGGGAGA                                                 NOV21q, SNP13375494 of   SEQ ID NO: 538       MW at 99077.0kD                                 CG53908-01, Protein Sequence   SNP Pos: 682   899 aa   SNP Change: Val to Leu                             MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV           PATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTK       SQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH       SLVVRQARLADTANYTCVAKNTVARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNP       APLNGGAFCEGQNVHDRTVSSLLVSVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDL       DTRNCTSDLCVHSASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPV       SIKPSKADNPHLLTIQPDLSTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE       EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDV       RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEQDVLHLGEEAP       SHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALK       ELVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCT       FTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLI       RQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGL       GQPDAGLFTVSEAEC                                                 SEQ ID NO: 539   2881 bp                                 NOV21r, SNP13375495 of   ORF Start: ATG at 87   ORF Stop: TGA at 2784                             CG53908-01, DNA Sequence   SNP Pos: 2305   SNP Change: G to A                             AGCTGGGGCTCCGGGCTGAGGCGCTAAAGCCGCCCTCCCGCCCGCGGGGCCCCGCGCCCGGCCCGCCC           GCCTGCCCGCCCGCGGCCATGGCCGTCCGGCCCGGCCTGTGGCCAGCGCTCCTGGGCATAGTCCTCGC       CGCTTGGCTCCGCGGCTCGGGTGCCCAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACC       CGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTG       CTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGT       GGACCACGTGATCGAGCGCAGCACAGACGGGAGCAGTGGTGAGCCGACCATGGAGGTCCGCATTAATG       TCTCAAGGCAGCAGGTCGAGAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGC       TCCTCGGGCACCACCAAGAGTCAGAAGGCCTACATCCGCATAGCCAGATTGCGCAAGAACTTCGAGCA       GGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCA       TCCCTCCAGCCGAGGTGGAGTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTA       TACATCACGCGGGAGCACAGCCTGGTGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTG       CGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTG       GGTGGTCGACGTGGACCGAGTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGC       CGGAGCTGCACCAACCCGGCGCCTCTCAACGGGGGCGCTTTCTGTGAGGGGCAGAATGTCCATGACCG       CACCGTCTCCTCTCTGCTTGTCTCTGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTG       GGCTGGACTGCACCCACTGGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAG       TGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTACACAGTGCTTCTGGCCC       TCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCGTCCATTCTCACC       TCAGGCTTCCAGCCCGTCAGCATCAAGCCCAGCAAAGCAGACAACCCCCATCTGCTCACCATCCAGCC       GGACCTCAGCACCACCACCACCTACCAGGGCAGTCTCTGTCCCCGGCAGGATGGGCCCAGCCCCAAGT       TCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACACACTGCACCACAGCTCT       CCCACCTCTGAGGCCGAGGAGTTCGTCTCCCGCCTCTCCACCCAGAACTACTTCCGCTCCCTGCCCCG       AGGCACCAGCAACATGACCTATGGGACCTTCAACTTCCTCGGGGGCCGGCTGATGATCCCTAATACAG       GTATCAGCCTCCTCATCCCCCCAGATGCCATACCCCGAGGGAAGATCTATGAGATCTACCTCACGCTG       CACAAGCCGGAAGACGTGAGGTTGCCCCTAGCTGGCTGTCAGACCCTGCTGAGTCCCATCGTTAGCTG       TGGACCCCCTGGCGTCCTGCTCACCCGGCCAGTCATCCTGGCTATGGACCACTGTGGGGAGCCCAGCC       CTGACAGCTGGAGCCTGCGCCTCAAAAAGCAGTCGTGCGAGGGCAGCTGGGAGCAGGATGTGCTGCAC       CTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCCTGCTACGTCTTCAC       CGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCGCCAAGCGCCTCAAGC       TGCTTCTGTTTGCGCCGGTGGCCTGCACCTCCCTCGAGTACAACATCCGGGTCTACTGCCTGCATGAC       ACCCACGATGCACTCAAGGAGGTGGTGCAGCTGGAGAAGCAGCTGGGGGGACAGCTGATCCAGGAGCC       ACGGGTCCTGCACTTCAAGGACAGTTACCACAACCTGCGCCTATCCATCCACGATGTGCCCAGCTCCC       TGTGGAAGAGTAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTTTATCACATCTGGAATGACACGCAG       CGGTACTTGCACTGCACCTTCACCCTGGAGCGTGTCAGCCCCAGCACTAGTGACCTGGCCTGCAAGCT       GTGGGTGTGGCAGGTGGAGGGCGACGGGCAGAGCTTCAGCATCAACTTCAACATCACCAAGGACACAA       AAGATCCCCTTCCTCATTCGGCAGAAGATAATTTCCAGCCTGGACCCACCCTGTAGGCGGGGTGCCGA       CTGGCGGACTCTGGCCCAGAAACTCCACCTGGACAGCCATCTCAGCTTCTTTGCCTCCAAGCCCAGCC       CCACAGCCATGATCCTCAACCTGTGGGAGGCGCGGCACTTCCCCAACGGCAACCTCAGCCAGCTGGCT       GCAGCAGTGGCTGGACTGGGCCAGCCAGACGCTGGCCTCTTCACAGTGTCGGAGGCTGAGTGCTGAGG       CCGGCCAGGCCCGACACCTACACTCTCACCAGCTTTGGCACCCACCAAGGACAGGCAGAAGCCGGACA       GGGGCCCTTCCCCACACCGGGGAGA                                                 NOV21r, SNP13375495 of   SEQ ID NO: 540       MW at 99121.0kD                                 CG53908-01, Protein Sequence   SNP Pos: 740   899 aa   SNP Change: Gly to Asp                             MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV           PATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTK       SQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH       SLVVRQARLADTANYTCVAKNIVARPRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNP       APLNGGAFCEGQNVHDRTVSSLLVSVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDL       DTRNCTSDLCVHSASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPV       SIKPSKADNPHLLTIQPDLSTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE       EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDV       RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEQDVLHLGEEAP       SHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALK       EVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNDTQRYLHCT       FTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLI       RQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGL       GQPDAGLFTVSEAEC                                                 SEQ ID NO: 541   2881 bp                                 NOV21s, SNP13375140 of   ORF Start: ATG at 87   ORF Stop: TGA at 2784                             CG53908-01, DNA Sequence   SNP Pos: 2325   SNP Change: T to C                             AGCTGGGGCTCCGGGCTGAGGCGCTAAAGCCGCCCTCCCGCCCGCGGGGCCCCGCGCCCGGCCCGCCC           GCCTGCCCGCCCGCGGCCATGGCCGTCCGGCCCGGCCTGTGGCCAGCGCTCCTGGGCATAGTCCTCGC       CGCTTGGCTCCGCGGCTCGGGTGCCCAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACC       CGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTG       CTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGT       GGACCACGTGATCGAGCGCAGCACAGACGGGAGCAGTGGTGAGCCGACCATGGAGGTCCGCATTAATG       TCTCAAGGCAGCAGGTCGAGAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGC       TCCTCGGGCACCACCAAGAGTCAGAAGGCCTACATCCGCATAGCCAGATTGCGCAAGAACTTCGAGCA       GGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCA       TCCCTCCAGCCGAGGTGGAGTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTA       TACATCACGCGGGAGCACAGCCTGGTGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTG       CGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTG       GGTGGTCGACGTGGACCGAGTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGC       CGGAGCTGCACCAACCCGGCGCCTCTCAACGGGGGCGCTTTCTGTGAGGGGCAGAATGTCCATGACCG       CACCGTCTCCTCTCTGCTTGTCTCTGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTG       TGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTACACAc3TGCTTCTGGCCC       TGAGGACGTGGCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCTGCCTGGTCCTGCTGCTGCTTGTCC       TCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCGTCCATTCTCACC       TCAGGCTTCCAGCCCGTCAGCATCAAGCCCAGCAAAGCAGACAACCCCCATCTGCTCACCATCCAGCC       GGACCTCAGCACCACCACCACCTACCAGGGCAGTCTCTGTCCCCGGCAGGATGGGCCCAGCCCCAAGT       TCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACACACTGCACCACAGCTCT       CCCACCTCTGAGGCCGAGGAGTTCGTCTCCCGCCTCTCCACCCAGAACTACTTCCGCTCCCTGCCCCG       AGGCACCAGCAACATGACCTATGGGACCTTCAACTTCCTCGGGGGCCGGCTGATGATCCCTAATACAG       GTATCAGCCTCCTCATCCCCCCAGATGCCATACCCCGAGGGAAGATCTATGAGATCTACCTCACGCTG       CACAAGCCGGAAGACGTGAGGTTGCCCCTAGCTGGCTGTCAGACCCTGCTGAGTCCCATCGTTAGCTG       TGGACCCCCTGGCGTCCTGCTCACCCGGCCAGTCATCCTGGCTATGGACCACTGTGGGGAGCCCAGCC       CTGACAGCTGGAGCCTGCGCCTCAAAAAGCAGTCGTGCGAGGGCAGCTGGGAGCAGGATGTGCTGCAC       CTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCCTGCTACGTCTTCAC       CGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCGCCAAGCGCCTCAAGC       TGCTTCTGTTTGCGCCGGTGGCCTGCACCTCCCTCGAGTACAACATCCGGGTCTACTGCCTGCATGAC       ACCCACGATGCACTCAAGGAGGTGGTGCAGCTGGAGAAGCAGCTGGGGGGACAGCTGATCCAGGAGCC       ACGGGTCCTGCACTTCAAGGACAGTTACCACAACCTGCGCCTATCCATCCACGATGTGCCCAGCTCCC       TGTGGAAGAGTAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTTTATCACATCTGGAATGGCACGCAG       CGGTACTTGCACCGCACCTTCACCCTGGAGCGTGTCAGCCCCAGCACTAGTGACCTGGCCTGCAAGCT       GTGGGTGTGGCAGGTGGAGGGCGACGGGCAGAGCTTCAGCATCAACTTCAACATCACCAAGGACACAA       AAGATCCCCTTCCTCATTCGGCAGAAGATAATTTCCAGCCTGGACCCACCCTGTAGGCGGGGTGCCGA       CTGGCGGACTCTGGCCCAGAAACTCCACCTGGACAGCCATCTCAGCTTCTTTGCCTCCAAGCCCAGCC       CCACAGCCATGATCCTCAACCTGTGGGAGGCGCGGCACTTCCCCAACGGCAACCTCAGCCAGCTGGCT       GCAGCAGTGGCTGGACTGGGCCAGCCAGACGCTGGCCTCTTCACAGTGTCGGAGGCTGAGTGCTGAGG       CCGGCCAGGCCCGACACCTACACTCTCACCAGCTTTGGCACCCACCAAGGACAGGCAGAAGCCGGACA       GGGGCCCTTCCCCACACCGGGGAGA                                                 NOV21s, SNP13375140 of   SEQ ID NO: 542       MW at 99116.0kD                                 CG53908-01, Protein Sequence   SNP Pos: 747   899 aa   SNP Change: Cys to Arg                             MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV           PATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTK       SQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH       SLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNP       APLNGGAFCEGQNVHDRTVSSLLVSVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDL       DTRNCTSDLCVHSASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPV       SIKPSKADNPHLLTIQPDLSTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSFAE       EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDV       RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEQDVLHLGEEAP       EVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHRT       FTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLI       RQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGL       GQPDAGLFTVSEAEC                                                 SEQ ID NO: 543   2881 bp                                 NOV21t, SNP13375139 of   ORF Start: ATG at 87   ORF Stop: TGA at 2784                             CG53908-01, DNA Sequence   SNP Pos: 2404   Change: A to G                             GCCTGCCCGCCCGCGGCCATGGCCGTCCGGCCCGGCCTGTGGCCAGCGCTCCTGGGCATAGTCCTCGC           CGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTG       CTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGT       GGACCACGTGATCGAGCGCAGCACAGACGGGAGCAGTGGTGAGCCGACCATGGAGGTCCGCATTAATG       TCTCAAGGCAGCAGGTCGAGAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGC       TCCTCGGGCACCACCAAGAGTCAGAAGGCCTACATCCGCATAGCCAGATTGCGCAAGAACTTCGAGCA       GGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCA       TCCCTCCAGCCGAGGTGGAGTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTA       TACATCACGCGGGAGCACAGCCTGGTGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTG       CGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTG       GGTGGTCGACGTGGACCGAGTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGC       CGGAGCTGCACCAACCCGGCGCCTCTCAACGGGGGCGCTTTCTGTGAGGGGCAGAATGTCCATGACCG       CACCGTCTCCTCTCTGCTTGTCTCTGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTG       GGCTGGACTGCACCCACTGGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAG       TGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTACACAGTGCTTCTGGCCC       TGAGGACGTGGCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCTGCCTGGTCCTGCTGCTGCTTGTCC       TCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCGTCCATTCTCACC       TCAGGCTTCCAGCCCGTCAGCATCAAGCCCAGCAAAGCAGACAACCCCCATCTGCTCACCATCCAGCC       GGACCTCAGCACCACCACCACCTACCAGGGCAGTCTCTGTCCCCGGCAGGATGGGCCCAGCCCCAAGT       TCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACACACTGCACCACAGCTCT       AGGCACCAGCAACATGACCTATGGGACCTTCAACTTCCTCGGGGGCCGGCTGATGATCCCTAATACAG       GTATCAGCCTCCTCATCCCCCCAGATGCCATACCCCGAGGGAAGATCTATGAGATCTACCTCACGCTG       CACAAGCCGGAAGACGTGAGGTTGCCCCTAGCTGGCTGTCAGACCCTGCTGAGTCCCATCGTTAGCTG       TGGACCCCCTGGCGTCCTGCTCACCCGGCCAGTCATCCTGGCTATGGACCACTGTGGGGAGCCCAGCC       CTGACAGCTGGAGCCTGCGCCTCAAAAAGCAGTCGTGCGAGGGCAGCTGGGAGCAGGATGTGCTGCAC       CTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCCTGCTACGTCTTCAC       CGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCGCCAAGCGCCTCAAGC       TGCTTCTGTTTGCGCCGGTGGCCTGCACCTCCCTCGAGTACAACATCCGGGTCTACTGCCTGCATGAC       ACCCACGATGCACTCAAGGAGGTGGTGCAGCTGGAGAAGCAGCTGGGGGGACAGCTGATCCAGGAGCC       ACGGGTCCTGCACTTCAAGGACAGTTACCACAACCTGCGCCTATCCATCCACGATGTGCCCAGCTCCC       TGTGGAAGAGTAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTTTATCACATCTGGAATGGCACGCAG       CGGTACTTGCACTGCACCTTCACCCTGGAGCGTGTCAGCCCCAGCACTAGTGACCTGGCCTGCAAGCT       GTGGGTGTGGCAGGTGGAGGGCGGCGGGCAGAGCTTCAGCATCAACTTCAACATCACCAAGGACACAA       GGTTTGCTGAGCTGCTGGCTCTGGAGAGTGAAGCGGGGGTCCCAGCCCTGGTGGGCCCCAGTGCCTTC       CTGGCGGACTCTGGCCCAGAAACTCCACCTGGACAGCCATCTCAGCTTCTTTGCCTCCAAGCCCAGCC       CCACAGCCATGATCCTCAACCTGTGGGAGGCGCGGCACTTCCCCAACGGCAACCTCAGCCAGCTGGCT       GCAGCAGTGGCTGGACTGGGCCAGCCAGACGCTGGCCTCTTCACAGTGTCGGAGGCTGAGTGCTGAGG       CCGGCCAGGCCCGACACCTACACTCTCACCAGCTTTGGCACCCACCAAGGACAGGCAGAAGCCGGACA       GGGGCCCTTCCCCACACCGGGGAGA                                                 NOV21t, SNP13375139 of   SEQ ID NO: 544       MW at 99005.0kD                                 CG53908-01, Protein Sequence   SNP Pos: 773   899 aa   SNP Change: Asp to Gly                             MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYTVKNKPVLLVCKAV           PATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTK       SQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH       SLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNP       APLNGGAFCEGQNVHDRTVSSLLVSVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDL       DTRNCTSDLCVHSASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPV       SIKPSKADNPHLLTIQPDLSTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE       EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDV       RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEQDVLHLGEEAP       SHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALK       EVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCT       FTLERVSPSTSDLACKLWVWQVEGGGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLI       RQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGL       GQPDAGLFTVSEAEC                                                 SEQ ID NO: 545   2881 bp                                 NOV21u, SNP13375496 of   ORF Start: ATG at 87   ORF Stop: TGA at 2784                             CG53908-01, DNA Sequence   SNP Pos: 2676   SNP Change: T to C                             AGCTGGGGCTCCGGGCTGAGGCGCTAAAGCCGCCCTCCCGCCCGCGGGGCCCCGCGCCCGGCCCGCCC           GCCTGCCCGCCCGCGGCCATGGCCGTCCGGCCCGGCCTGTGGCCAGCGCTCCTGGGCATAGTCCTCGC       CGCTTGGCTCCGCGGCTCGGGTGCCCAGCAGAGTGCCACCGTGGCCAACCCAGTGCCTGGTGCCAACC       CGGACCTGCTTCCCCACTTCCTGGTGGAGCCCGAGGATGTGTACATCGTCAAGAACAAGCCAGTGCTG       CTTGTGTGCAAGGCCGTGCCCGCCACGCAGATCTTCTTCAAGTGCAACGGGGAGTGGGTGCGCCAGGT       TCTCAAGGCAGCAGGTCGAGAAGGTGTTCGGGCTGGAGGAATACTGGTGCCAGTGCGTGGCATGGAGC       TCCTCGGGCACCACCAAGAGTCAGAAGGCCTACATCCGCATAGCCAGATTGCGCAAGAACTTCGAGCA       GGAGCCGCTGGCCAAGGAGGTGTCCCTGGAGCAGGGCATCGTGCTGCCCTGCCGTCCACCGGAGGGCA       TCCCTCCAGCCGAGGTGGAGTGGCTCCGGAACGAGGACCTGGTGGACCCGTCCCTGGACCCCAATGTA       TACATCACGCGGGAGCACAGCCTGGTGGTGCGACAGGCCCGCCTTGCTGACACGGCCAACTACACCTG       CGTGGCCAAGAACATCGTGGCACGTCGCCGCAGCGCCTCCGCTGCTGTCATCGTCTACGTGAACGGTG       GGTGGTCGACGTGGACCGAGTGGTCCGTCTGCAGCGCCAGCTGTGGGCGCGGCTGGCAGAAACGGAGC       CGGAGCTGCACCAACCCGGCGCCTCTCAACGGGGGCGCTTTCTGTGAGGGGCAGAATGTCCATGACCG       CACCGTCTCCTCTCTGCTTGTCTCTGTGGACGGCAGCTGGAGCCCGTGGAGCAAGTGGTCGGCCTGTG       GGCTGGACTGCACCCACTGGCGGAGCCGTGAGTGCTCTGACCCAGCACCCCGCAACGGAGGGGAGGAG       TGCCAGGGCACTGACCTGGACACCCGCAACTGTACCAGTGACCTCTGTGTACACAGTGCTTCTGGCCC       TGAGGACGTGGCCCTCTATGTGGGCCTCATCGCCGTGGCCGTCTGCCTGGTCCTGCTGCTGCTTGTCC       TCATCCTCGTTTATTGCCGGAAGAAGGAGGGGCTGGACTCAGATGTGGCTGACTCGTCCATTCTCACC       TCCAGCTCACCAATGGGCACCTGCTCAGCCCCCTGGGTGGCGGCCGCCACACACTGCACCACAGCTCT       CCCACCTCTGAGGCCGAGGAGTTCGTCTCCCGCCTCTCCACCCAGAACTACTTCCGCTCCCTGCCCCG       AGGCACCAGCAACATGACCTATGGGACCTTCAACTTCCTCGGGGGCCGGCTGATGATCCCTAATACAG       GTATCAGCCTCCTCATCCCCCCAGATGCCATACCCCGAGGGAAGATCTATGAGATCTACCTCACGCTG       TGGACCCCCTGGCGTCCTGCTCACCCGGCCAGTCATCCTGGCTATGGACCACTGTGGGGAGCCCAGCC       CTGACAGCTGGAGCCTGCGCCTCAAAAAGCAGTCGTGCGAGGGCAGCTGGGAGCAGGATGTGCTGCAC       CTGGGCGAGGAGGCGCCCTCCCACCTCTACTACTGCCAGCTGGAGGCCAGTGCCTGCTACGTCTTCAC       CGAGCAGCTGGGCCGCTTTGCCCTGGTGGGAGAGGCCCTCAGCGTGGCTGCCGCCAAGCGCCTCAAGC       TGCTTCTGTTTGCGCCGGTGGCCTGCACCTCCCTCGAGTACAACATCCGGGTCTACTGCCTGCATGAC       ACCCACGATGCACTCAAGGAGGTGGTGCAGCTGGAGAAGCAGCTGGGGGGACAGCTGATCCAGGAGCC       ACGGGTCCTGCACTTCAAGGACAGTTACCACAACCTGCGCCTATCCATCCACGATGTGCCCAGCTCCC       TGTGGAAGAGTAAGCTCCTTGTCAGCTACCAGGAGATCCCCTTTTATCACATCTGGAATGGCACGCAG       CGGTACTTGCACTGCACCTTCACCCTGGAGCGTGTCAGCCCCAGCACTAGTGACCTGGCCTGCAAGCT       GTGGGTGTGGCAGGTGGAGGGCGACGGGCAGAGCTTCAGCATCAACTTCAACATCACCAAGGACACAA       GGTTTGCTGAGCTGCTGGCTCTGGAGAGTGAAGCGGGGGTCCCAGCCCTGGTGGGCCCCAGTGCCTTC       AAGATCCCCTTCCTCATTCGGCAGAAGATAATTTCCAGCCTGGACCCACCCTGTAGGCGGGGTGCCGA       CTGGCGGACTCTGGCCCAGAAACTCCACCTGGACAGCCATCTCAGCTTCTTTGCCTCCAAGCCCAGCC       CCACAGCCATGATCCTCAACCTGCGGGAGGCGCGGCACTTCCCCAACGGCAACCTCAGCCAGCTGGCT       GCAGCAGTGGCTGGACTGGGCCAGCCAGACGCTGGCCTCTTCACAGTGTCGGAGGCTGAGTGCTGAGG       CCGGCCAGGCCCGACACCTACACTCTCACCAGCTTTGGCACCCACCAAGGACAGGCAGAAGCCGGACA       GGGGCCCTTCCCCACACCGGGGAGA                                                 NOV21u, SNP13375496 of   SEQ ID NO: 546       MW at 99032.9kD                                 CG53908-01, Protein Sequence   SNP Pos: 864   899 aa   SNP Change: Trp to Arg                             MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAV           PATQIFFKCNGEWVRQVDHVTERSTDGSSGEPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTK       SQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH       SLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRGWQKRSRSCTNP       APLNGGAFCEGQNVHDRTVSSLLVSVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDL       DTRNCTSDLCVHSASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPV       SIKPSKADNPHLLTIQPDLSTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAE       EFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDV       RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEQDVLHLGEEAP       SHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALK       EVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCT       FTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLI       RQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLREARHFPNGNLSQLAAAVAGL       GQPDAGLFTVSEAEC                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 21B.  
                   TABLE 21 B                       Comparison of the NOV21 protein sequences.                                            NOV21a   MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKP           NQV21b   -------------------------QQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKP       NOV21c   ----------------------TGSQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKP       NOV21d   -------------------------QQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKP       NOV21e   MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKP       NOV21f   -------------------------QQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKP       NOV21g   ---------ALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKP       NOV21h   -------------------------QQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKP               NOV21a   VLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQQVEKVFGLE       N0V21b   VLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQQVEKVFGLE       N0V21c   VLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLE       NOV21d   VLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGEPTMEVRINVSRQQVEKVFGLE       NOV21e   VLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLE       NOV21f   VLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLE       NOV21g   VLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLE       NOV21h   VLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLE               NOV21a   EYWCQCVAWSSSGTTKSQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAE       NOV21b   EYWCQCVAWSSSGTTKSQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAE       NOV21c   EYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAE       NOV21d   EYWCQCVAWSSSGTTKSQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAE       NOV21e   EYWCQCVAWSSSGTTKSQKAYIRIARLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAE       NOV21f   EYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAE       NOV21g   EYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAE       NOV21h   EYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAE               NOV21a   VEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAXNIVARRRSASAAVIVY       NOV21b   VEWLRNEDLVDPSLDPNVYITREHSLVVRQAPLADTANYTCVAKNIVARRRSASAAVIVY       NOV21c   VEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVY       NOV21d   VEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVY       NOV21e   VEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVY       NOV21t   VEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVY       NOV21g   VEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVY       NOV21h   VEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVY               NOV21a   VNGGWSTWTEWSVCSASCGRGWQKRSRSCTNPAPLNGGAFCEGQNVHDRTVSSLLVSVDG       NOV21b   VNGGWSTWTEWSVCSASCGRGWQKRSRSCTNPAPLNGGAFCEGQNVHDRTVSSLLVSVDG       NOV21c   VNGGWSTWTEWSVCSASCGRGWQKRSRSCTNPAPLNGGAFCEGQNVQK-TACATLCPVDG       NOV21d   VDG---------------------------------------------------------       NOV21e   VNGGWSTWTEWSVCSASCGRGWQKRSRSCTNPAPLNGGAFCEGQ-NVQKTACATLCPVDG       NOV21f   VNGGWSTWTEWSVCSASCGRGWQKRSRSCTNPAPLNGGAFCEGQNVQK-TACATLCPVDG       NOV21g   VDG---------------------------------------------------------       NOV21h   VDG---------------------------------------------------------               NOV21a   SWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTPNCTSDLCVHSASGPEDV       NOV21b   SWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHSASG----       NOV21c   SWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHSASGEFG-       NOV21d   SWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHSASGPEDV       NOV21e   SWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHSASGPEDV       NOV21f   SWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHSASG----       NOV21g   SWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHTASGPEDV       NOV21h   SWSPWSKWSACGLGCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHTASGPEDV               NOV21a   ALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADNPHL       NOV21b   ------------------------------------------------------------       NOV21c   ------------------------------------------------------------       NOV21d   ALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSTLTSGFQPVSIKPSKADN---       NOV21e   ALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADNPHL       NOV21f   ------------------------------------------------------------       NOV21g   ALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADNPHL       NOV21h   ALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADNPHL               NOV21a   LTIQPDLS-TTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAEEFV       NOV21b   ------------------------------------------------------------       NOV21c   ------------------------------------------------------------       NOV21d   ------------------------------------------------------------       NOV21e   LTIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAEEFV       NOV21f   ------------------------------------------------------------       NOV21g   LTIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAEEFV       NOV21h   LTIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAEEFV               NOV21a   SRLSTQNYFRSLPRGTSNNTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLH       NOV21b   ------------------------------------------------------------       NOV21c   ------------------------------------------------------------       NOV21d   ------------------------------------------------------------       NOV21e   SRLSTQNYFRSLPRGTSNNTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLH       NOV21f   ------------------------------------------------------------       NOV21g   SRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLH       NOV21h   SRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLH               NOV21a   KPEDVRLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGS       NOV21b   ------------------------------------------------------------       NOV21c   ------------------------------------------------------------       NOV21d   ------------------------------------------------------------       NOV21e   KFEDVRLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGS       NOV21f   ------------------------------------------------------------       NOV21g   KPEDVRLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGS       NOV21h   KPEDVRLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGS               NOV21a   WEQDVLHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVA       NOV21b   ------------------------------------------------------------       NOV21c   ------------------------------------------------------------       NOV21d   ------------------------------------------------------------       NOV21e   WED-VLHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVA       NOV21f   ------------------------------------------------------------       NOV21g   WED-VLHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVA       NOV21h   WED-VLHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVA               NOV21a   CTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSS       NOV21b   ------------------------------------------------------------       NOV21c   ------------------------------------------------------------       NOV21d   ------------------------------------------------------------       NOV21e   CTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSS       NOV21f   ------------------------------------------------------------       NOV21g   CTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSS       NOV21h   CTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSS               NOV21a   LWKSKLLVSYQEIPFYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWVWQVEGDGQSFSI       NOV21b   ------------------------------------------------------------       NOV21c   ------------------------------------------------------------       NOV21d   ------------------------------------------------------------       NOV21e   LWKSKLLVSYQEIPFYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWVWQVEGDGQSFSI       NOv21f   ------------------------------------------------------------       NOV21g   LWKSKLLVSYQEIPFYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWVWQVEGDGQSFSI       NOV21h   LWKSKLLVSYQEIPFYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWVWQVEGDGQSFSI               NOV21a   NFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTLAQ       NOV21b   ------------------------------------------------------------       NOV21c   ------------------------------------------------------------       NOV21d   ------------------------------------------------------------       NOV21e   NFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTLAQ       NOV21f   ------------------------------------------------------------       NOV21g   NFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTLAQ       NOV21h   NFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTLAQ               NOV21a   KLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLGQPDAGLFTVSEAEC       NOV21b   ------------------------------------------------------------       NOV21c   ------------------------------------------------------------       NOV21d   ------------------------------------------------------------       NOV21e   KLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLGQPDAGLFTVSEAEC       NOV21f   ------------------------------------------------------------       NOV21g   KLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAvAGLGQPDAGLFTVSEAEC       NOV21h   KLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLGQPDAGLFTVSEAEC               NOV21a   (SEQ ID NO: 506)       NOV21b   (SEQ ID NO: 508)       NOV21c   (SEQ ID NO: 510)       NOV21d   (SEQ ID NO: 512)       NOV21e   (SEQ ID NO: 514)       NOV21f   (SEQ ID NO: 516)       NOV21g   (SEQ ID NO: 518)       NOV21h   (SEQ ID NO: 520)                  
 
      Further analysis of the NOV21a protein yielded the following properties shown in Table 21C.  
               TABLE 21C                       Protein Sequence Properties NOV21a                                        SignalP analysis:   Cleavage site between residues 26 and 27       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 4; pos. chg 1; neg. chg 0           H-region:   length 16; peak value 9.57           PSG score:   5.17                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 1.79           possible cleavage site: between 25 and 26                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 25)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 26           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 367-383               −19.00                             PERIPHERAL   Likelihood = 0.85 (at 61)                         ALOM score: −19.00 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 12           Charge difference: −1.0 C(1.0)-N(2.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 1a (cytoplasmic tail 384 to 899)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   2   Hyd Moment(75):   9.35           Hyd Moment(95):   6.17   G content:   5           D/E content:   1   S/T content:   3                         Score: −4.19       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 31 LRG|SG                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 9.2%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: AVRP                 none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: found                         LL at 420           LL at 455           LL at 519           LL at 554           LL at 567           LL at 652           LL at 653           LL at 725                 checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 70.6       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         44.4%: endoplasmic reticulum           22.2%: Golgi           11.1%: plasma membrane           11.1%: vesicles of secretory system           11.1%: extracellular, including cell wall                 &gt;&gt; prediction for CG53908-01 is end (k = 9)                  
 
      A search of the NOV21 a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 21D.  
               TABLE 21D                           Geneseq Results for NOV21a                                         NOV21a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value                                             AAU79939   Human UNC5-like protein NOV1 -   1 . . . 899   899/899   (100%)   0.0             Homo sapiens , 899 aa.   1 . . . 899   899/899   (100%)           [WO200229038-A2, 11-APR-2002]       AAU85403   Human protein NOV1 -  Homo sapiens ,   1 . . . 899   888/900   (98%)   0.0           898 aa. [WO200210216-A2, 07-FEB-   1 . . . 898   890/900   (98%)           2002]       AAU97899   Human netrin binding membrane   1 . . . 899   886/900   (98%)   0.0           receptor UNC5H-1 protein -  Homo     1 . . . 898   889/900   (98%)             sapiens , 898 aa. [WO200233080-A2,           25-APR-2002]       AAU10543   Rat netrin receptor UNC5H1 (YSG7)   1 . . . 899   852/900   (94%)   0.0           polypeptide -  Rattus  sp, 898 aa.   1 . . . 898   871/900   (96%)           [WO200175440-A2, 11-OCT-2001]       AAU97900   Rat netrin binding membrane receptor   1 . . . 899   852/900   (94%)   0.0           UNC5H-1 protein -  Rattus  sp, 898 aa.   1 . . . 898   871/900   (96%)           [WO200233080-A2, 25-APR-2002]                  
 
      In a BLAST search of public sequence databases, the NOV21a protein was found to have homology to the proteins shown in the BLASTP data in Table 21E.  
               TABLE 21E                          Public BLASTP Results for NOV21a                                         NOV21a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q8K1S4   Netrin receptor Unc5h1 -  Mus      1 . . . 899   858/900 (95%)   0.0             musculus  (Mouse), 898 aa.    1 . . . 898   879/900 (97%)       O08721   Transmembrane receptor UNC5H1 -    1 . . . 899   852/900 (94%)   0.0             Rattus norvegicus  (Rat), 898 aa.    1 . . . 898   871/900 (96%)       Q96GP4   Similar to transmembrane receptor   359 . . . 899   540/542 (99%)   0.0           Unc5H1 -  Homo sapiens  (Human),    4 . . . 544   540/542 (99%)           544 aa (fragment).       O08747   Rostral cerebellar malformation    9 . . . 898   515/913 (56%)   0.0           protein -  Mus musculus  (Mouse), 931    26 . . . 930   668/913 (72%)           aa.       Q8CD16   Unc5 homolog -  Mus musculus      9 . . . 898   515/932 (55%)   0.0           (Mouse), 950 aa.    26 . . . 949   668/932 (71%)                  
 
      PFam analysis predicts that the NOV21a protein contains the domains shown in the Table 21F.  
               TABLE 21F                          Domain Analysis of NOV21a                                             Identities/                       Similarities           Pfam   NOV21a   for the   Expect           Domain   Match Region   Matched Region   Value                                                     ig   163 . . . 223   17/63   (27%)   0.0015                   38/63   (60%)           tsp_1   246 . . . 287   20/53   (38%)   0.00036                   30/53   (57%)           tsp_1   303 . . . 350   21/53   (40%)   0.0017                   32/53   (60%)           ZU5   495 . . . 598   47/115   (41%)   6.3e−56                   103/115   (90%)           death   818 . . . 898   26/88   (30%)   3.5e−14                   64/88   (73%)                      
 
     Example 22.  
      The NOV22 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 22A.  
               TABLE 22A                       NOV22 Sequence Analysis                                                NOV22a, CG53944-02   SEQ ID NO: 547   1887 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAG at 1885                       ATG GCCATCCTCCCGTTGCTCCTGTGCCTGCTGCCGCTGGCCCCTGCCTCATCCCCACCCCAGTCAGC           CACACCCAGCCCATGTCCCCGCCGCTGCCGCTGCCAGACACAGTCGCTGCCCCTAAGCGTGCTGTGCC       CAGGGGCAGGCCTCCTGTTCGTGCCACCCTCGCTGGACCGCCGGGCAGCCGAGCTGCGGCTGGCAGAC       AACTTCATCGCCTCCGTGCGCCGCCGCGACCTGGCCAACATGACAGGCCTGCTGCATCTGAGCCTGTC       GCGGAACACCATCCGCCACGTGGCTGCCGGCGCCTTCGCCGACCTGCGGGCCCTGCGTGCCCTGCACC       ATCCTCAGCAACAACCAGCTGGCAGCGCTGGCGGCCGGCGCCCTGGATGATTGTGCCGAGACACTGGA       GGACCTCGACCTCTCCTACAACAACCTCGAGCAGCTGCCCTGGGAGGCCCTGGGCCGCCTGGGCAACG       TCAACACGTTGGGCCTCGACCACAACCTGCTGGCTTCTGTGCCCGCCGGCGCTTTTTCCCGCCTGCAC       AAGCTGGCCCGGCTGGACATGACCTCCAACCGCCTGACCACAATCCCACCCGACCCACTCTTCTCCCG       CCTGCCCCTGCTCGCCAGGCCCCGGGGCTCGCCCGCCTCTGCCCTGGTGCTGGCCTTTGGCGGGAACC       CCCTGCACTGCAACTGCGAGCTGGTGTGGCTGCGTCGCCTGGCGCGGGAGGACGACCTCGAGGCCTGC       GCGTCCCCACCTGCTCTGGGCGGCCGCTACTTCTGGGCGGTGGGCGAGGAGGAGTTTGTCTGCGAGCC       GCCCGTGGTGACTCACCGCTCACCACCTCTGGCTGTGCCCGCAGGTCGGCCGGCTGCCCTGCGCTGCC       GGGCAGTGGGGGACCCAGAGCCCCGTGTGCGTTGGGTGTCACCCCAGGGCCGGCTGCTAGGCAACTCA       AGCCGTGCCCGCGCCTTCCCCAATGGGACGCTGGAGCTGCTGGTCACCGAGCCGGGTGATGGTGGCAT       CTTCACCTGCATTGCGGCCAATGCAGCTGGCGAGGCCACAGCTGCTGTGGAGCTGACTGTGGGTCCCC       CACCACCTCCTCAGCTAGCCAACAGCACCAGCTGTGACCCCCCGCGGGACGGGGATCCTGATGCTCTC       ACCCCACCCTCCGCTGCCTCTGCTTCTGCCAAGGTGGCCGACACTGGGCCCCCTACCGACCGTGGCGT       CCAGGTGACTGAGCACGCGGCCACAGCTGCTCTTGTCCAGTGGCCGGATCAGCGGCCTATCCCGGGCA       GAGAGCCGCTCGTTCCTGCTGACGGACCTGGCGTCAGGCCGGACCTACGATCTGTGCGTGCTCGCCGT       GTATGAGGACAGCGCCACGGGGCTCACGGCCACGCGGCCTGTGGGCTGCGCCCGCTTCTCCACCGAAC       CTGCGCTGCGGCCATGCGGGGCGCCGCACGCTCCCTTCCTGGGCGGCACGATGATCATCGCGCTGGGC       GGCGTCATCGTAGCCTCGGTACTGGTCTTCATCTTCGTGCTGCTAATGCGCTACAAGGTGCACGGCGG       CCAGCCCCCCGGCAAGGCCAAGATTCCCGCGCCTGTTAGCAGCGTTTGCTCCCAGACCAACGGCGCCC       TGGGCCCCACGCCCACGCCCGCCCCGCCCGCCCCGGAGCCCGCGGCGCTCAGGGCCCACACCGTGGTC       CAGCTGGACTGCGAGCCCTGGGGGCCCGGCCACGAACCTGTGGGACCC TAG                                           NOV22a, CG53944-02                       Protein Sequence   SEQ ID NO: 548   1628 aa   MW at 66259.1kD                     MAILPLLLCLLPLAPASSPPQSATPSPCPPRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLAD           NFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLPALRALHLDGNRLTSLGEGQLRGLVNLRHL       ILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLH       KLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAREDDLEAC       ASPPALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNS       SRAPAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPPPPQLANSTSCDPPRDGDPDAL       TPPSAASASAKVADTGPPTDRGVQVTEHGATAALVQWPDQRPIPGIRMYQIQYNSSADDILVYRMIPA       ESRSFLLTDLASGRTYDLCVLAVYEDSATGLTATRPVGCARFSTEPALRPCGAPHAPFLGGTMIIALG       GVIVASVLVFIFVLLMRYKVHGGQPPGKAKIPAPVSSVCSQTNGALGPTPTPAPPAPEPAALRAHTVV       QLDCEPWGPGHEPVGP                                     NOV22b, CG53944-01   SEQ ID NO: 549   1887 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAG at 1885                       ATG GCCATCCTCCCGTTGCTCCTGTGCCTGCTGCCGCTGGCCCCTGCCTCATCCCCACCCCAGTCAGC           CACACCCAGCCCATGTCCCCGCCGCTGCCGCTGCCAGACACAGTCGCTGCCCCTAAGCGTGCTGTGCC       AACTTCATCGCCTCCGTGCGCCGCCGCGACCTGGCCAACATGACAGGCCTGCTGCATCTGAGCCTGTC       GCGGAACACCATCCGCCACGTGGCTGCCGGCGCCTTCGCCGACCTGCGGGCCCTGCGTGCCCTGCACC       TGGATGGCAACCGGCTGACCTCACTGGGCGAGGGCCAGCTGCGCGGCCTGGTCAACTTGCGCCACCTC       ATCCTCAGCAACAACCAGCTGGCAGCGCTGGCGGCCGGCGCCCTGGATGATTGTGCCGAGACACTGGA       GGACCTCGACCTCTCCTACAACAACCTCGAGCAGCTGCCCTGGGAGGCCCTGGGCCGCCTGGGCAACG       TCAACACGTTGGGCCTCGACCACAACCTGCTGGCTTCTGTGCCCGCCGGCGCTTTTTCCCGCCTGCAC       AAGCTGGCCCGGCTGGACATGACCTCCAACCGCCTGACCACAATCCCACCCGACCCACTCTTCTCCCG       CCTGCCCCTGCTCGCCAGGCCCCGGGGCTCGCCCGCCTCTGCCCTGGTGCTGGCCTTTGGCGGGAACC       CCCTGCACTGCAACTGCGAGCTGGTGTGGCTGCGTCGCCTGGCGCGGGAGGACGACCTCGAGGCCTGC       GCGTCCCCACCTGCTCTGGGCGGCCGCTACTTCTGGGCGGTGGGCGAGGAGGAGTTTGTCTGCGAGCC       GCCCGTGGTGACTCACCGCTCACCACCTCTGGCTGTGCCCGCAGGTCGGCCGGCTGCCCTGCGCTGCC       GGGCAGTGGGGGACCCAGAGCCCCGTGTGCGTTGGGTGTCACCCCAGGGCCGGCTGCTAGGCAACTCA       AGCCGTGCCCGCGCCTTCCCCAATGGGACGCTGGAGCTGCTGGTCACCGAGCCGGGTGATGGTGGCAT       CTTCACCTGCATTGCGGCCAATGCAGCTGGCGAGGCCACAGCTGCTGTGGAGCTGACTGTGGGTCCCC       CACCACCTCCTCAGCTAGCCAACAGCACCAGCTGTGACCCCCCGCGGGACGGGGATCCTGATGCTCTC       ACCCCACCCTCCGCTGCCTCTGCTTCTGCCAAGGTGGCCGACACTGGGCCCCCTACCGACCGTGGCGT       CCAGGTGACTGAGCACGGGGCCACAGCTGCTCTTGTCCAGTGGCCGGATCAGCGGCCTATCCCGGGCA       TCCGCATGTACCAGATCCAGTACAACAGCTCGGCTGATGACATCCTCGTCTACAGGATGATCCCGGCG       GAGAGCCGCTCGTTCCTGCTGACGGACCTGGCGTCAGGCCGGACCTACGATCTGTGCGTGCTCGCCGT       GTATGAGGACAGCGCCACGGGGCTCACGGCCACGCGGCCTGTGGGCTGCGCCCGCTTCTCCACCGAAC       CTGCGCTGCGGCCATGCGGGGCGCCGCACGCTCCCTTCCTGGGCGGCACGATGATCATCGCGCTGGGC       GGCGTCATCGTAGCCTCGGTACTGGTCTTCATCTTCGTGCTGCTAATGCGCTACAAGGTGCACGGCGG       CCAGCCCCCCGGCAAGGCCAAGATTCCCGCGCCTGTTAGCAGCGTTTGCTCCCAGACCAACGGCGCCC       TGGGCCCCACGCCCACGCCCGCCCCGCCCGCCCCGGAGCCCGCGGCGCTCAGGGCCCACACCGTGGTC       CAGCTGGACTGCGAGCCCTGGGGGCCCGGCCACGAACCTGTGGGACCC TAG                                           NOV22b, CG53944-01                       Protein Sequence   SEQ ID NO: 550   628 aa   MW at 66259.1kD                     MAILPLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLAD           NFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHL       ILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLH       KLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAREDDLEAC       ASPPALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNS       SRAPAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTVGPPPPPQLANSTSCDPPRDGDPDAL       TPPSAASASAKVADTGPPTDRGVQVTEHGATAAIJVQWPDQRPIPGIRMYQIQYNSSADDILVYRMPA       ESRSFLLTDLASGRTYDLCVLAVYEDSATGLTATRPVGCARFSTEPALRPCGAPHAPFLGGTMIIALG       GVIVASVLVFIFVLLMRYKVHGGQPPGKAKIPAPVSSVCSQTNGALGPTPTPAPPAPEPAALRAHTVV       QLDCEPWGPGHEPVGP                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 22B.  
                   TABLE 22B                       Comparison of the NOV22 protein sequences.                                            NOV22a   MAILPLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRR           NOV22b   MAILPLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRR               NOV22a   AAELRLADNFIASVRPRDLANMTGLLHLSLSRNTIRHVAAGAFADLEALRALHLDGNRLT       NOV22b   AAELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLT               NOV22a   SLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLG       NOV22b   SLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLG               NOV22a   NVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPAS       NOV22b   NVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPAS               NOV22a   ALVLAFGGNPLHCNCELVWLRRLAREDDLEACASPPALGGRYFWAVGEEEFVCEPPVVTH       NOV22b   ALVLAFGGNPLHCNCELVWLRRLAREDDLEACASPPALGGRYFWAVGEEEFVCEPPVVTH               NOV22a   RSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEPGD       NOV22b   RSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEPGD               NOV22a   GGIFTCIAANAAGEATAAVELTVGPPPPPQLANSTSCDPPRDGDPDALTPPSAASASAKV       NOV22b   GGIFTCIAANAAGEATAAVELTVGPPPPPQLANSTSCDPPRDGDPDALTPPSAASASAKV               NOV22a   ADTGPPTDRGVQVTEHGATAALVQWPDQRPIPGIRMYQIQYNSSADDILVYRMIPAESRS       NOV22b   ADTGPPTDRGVQVTEHGATAALVQWPDQRPIPGIRMYQIQYNSSADDILVYRMIPAESRS               NOV22a   FLLTDLASGRTYDLCVLAVYEDSATGLTATRPVGCARFSTEPALRPCGAPHAPFLGGTMI       NOV22b   FLLTDLASGRTYDLCVLAVYEDSATGLTATRPVGCARFSTEPALRPCGAPHAPFLGGTMI               NOV22a   IALGGVIVASVLVFIFVLLMRYKVHGGQPPGKAKIPAPVSSVCSQTNGALGPTPTPAPPA       NOV22b   IALGGVIVASVLVFIFVLLMRYKVHGGQPPGKAKIPAPVSSVCSQTNGALGPTPTPAPPA               NOV22a   PEPAALRAHTVVQLDCEPWGPGHEPVGP       NOV22b   PEPAALRAHTVVQLDCEPWGPGHEPVGP               NOV22a   (SEQ ID NO: 548)       NOV22b   (SEQ ID NO: 550)                  
 
      Further analysis of the NOV22a protein yielded the following properties shown in Table 22C.  
               TABLE 22C                       Protein Sequence Properties NOV22a                                        SignalP analysis:   Cleavage site between residues 17 and 18       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 0; pos. chg 0; neg. chg 0           H-region:   length 29; peak value 9.99           PSG score:   5.59                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 4.65           possible cleavage site: between 16 and 17                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 16)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 17           Tentative number of TMS(s) for the threshold 0.5: 2           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 543-559               −12.79                             PERIPHERAL   Likelihood = 2.44 (at 363)                         ALOM score: −12.79 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 8           Charge difference: 2.0 C(3.0)-N(1.0)           C &gt; N: C-terminal side will be inside                 &gt;&gt;&gt;Caution: Inconsistent mtop result with signal peptide       &gt;&gt;&gt; membrane topology: type 1a (cytoplasmic tail 560 to 628)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   3   Hyd Moment (75):   2.94           Hyd Moment (95):   1.64   G content:   2           D/E content:   1   S/T content:   9                         Score: −1.46       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 43 CRC|QT                 NUCDISC: discrimination of nuclear localization signals                         pat 4: none           pat7: PCPRRCR (3) at 27           pat7: PRRCRCQ (5) at 29           bipartite: none           content of basic residues: 8.4%           NLS Score: 0.22       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 55.5       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         44.4%: extracellular, including cell wall           22.2%: Golgi           22.2%: endoplasmic reticulum           11.1%: plasma membrane                 &gt;&gt; prediction for CG53944-02 is exc (k = 9)                  
 
      A search of the NOV22a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 22D.  
               TABLE 22D                          Geneseq Results for NOV22a                                         NOV22a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value                                             ABP69326   Human polypeplide SEQ ID NO 1373 -   1 . . . 628   628/628   (100%)   0.0             Homo sapiens , 628 aa.   1 . . . 628   628/628   (100%)           [WO200270539-A2, 12-SEP-2002]       AAG67523   Amino acid sequence of a human   1 . . . 628   628/628   (100%)   0.0           secreted polypeptide -  Homo sapiens ,   1 . . . 628   628/628   (100%)           628 aa. [WO200166690-A2, 13-SEP-2001]       AAB84469   Amino acid sequence of an interferon   1 . . . 628   628/628   (100%)   0.0           omega-1 like protein NOV2 -  Homo     1 . . . 628   628/628   (100%)             sapiens , 628 aa. [WO200142471-A2,           14-JUN-2001]       AAG65805   Human leucine-rich repeat (LRR) family   1 . . . 628   626/628   (99%)   0.0           member, 33395 polypeptide -  Homo     1 . . . 628   627/628   (99%)             sapiens , 628 aa. [WO200172827-A2,           04-OCT-2001]       ABG34079   Human Pro peptide #51 -  Homo     1 . . . 628   627/628   (99%)   0.0             sapiens , 627 aa. [WO200224888-A2,   1 . . . 627   627/628   (99%)           28-MAR-2002]                  
 
      In a BLAST search of public sequence databases, the NOV22a protein was found to have homology to the proteins shown in the BLASTP data in Table 22E.  
               TABLE 22E                          Public BLASTP Results for NOV22a                                         NOV22a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             Q9BTNO   Hypothetical protein -  Homo sapiens     1 . . . 628   628/628   (100%)   0.0           (Human), 628 aa.   1 . . . 628   628/628   (100%)       CAD10239   Sequence 1 from Patent WO0172827 -   1 . . . 628   626/628   (99%)   0.0             Homo sapiens  (Human), 628 aa.   1 . . . 628   627/628   (99%)       Q8BLY3   Hypothetical leucine-rich repeat   1 . . . 628   603/628   (96%)   0.0           containing protein -  Mus musculus     1 . . . 626   611/628   (97%)           (Mouse), 626 aa.       Q9ULH4   Hypothetical protein KIAA1246 -   23 . . . 603    310/585   (52%)   e−174             Homo sapiens  (Human), 832 aa   59 . . . 639    398/585   (67%)           (fragment).       Q9BE71   Hypothetical 84.7 kDa protein -   23 . . . 603    309/585   (52%)   e−174             Macaca fascicularis  (Crab eating   16 . . . 596    397/585   (67%)           macaque) (Cynomolgus monkey),           789 aa.                  
 
      PFam analysis predicts that the NOV22a protein contains the domains shown in the Table 22F.  
               TABLE 22F                          Domain Analysis of NOV22a                                     Identities/                   Similarities       Pfam   NOV22a Match   for the Matched       Domain   Region   Region   Expect Value                                     LRR    84 . . . 107    8/25 (32%)   0.86               21/25 (84%)       LRR   132 . . . 155   10/25 (40%)   0.27               20/25 (80%)       LRR   157 . . . 180   12/25 (48%)   0.026               19/25 (76%)       LRRCT   249 . . . 294   21/55 (38%)   4.3e−05               37/55 (67%)       ig   310 . . . 368   15/62 (24%)   1.2e−05               44/62 (71%)       fn3   425 . . . 505   18/84 (21%)   7.1e−05               55/84 (65%)                  
 
     Example 23.  
      The NOV23 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 23A.  
                   TABLE 23A                       NOV23 Sequence Analysis                                                NOV23a, CG54308-04   SEQ ID NO: 551   1284 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAA at 1276                       ATG GACTCTCTTGTTACAGCAAACACCAAATTTTGCTTTGATCTTTTTCAAGAGATAGGCAAAGATGA           TCGTCATAAAAACATATTTTTCTCTCCCCTGAGCCTCTCAGCTGCCCTTGGTATGGTACGCTTGGGTG       CTAGAAGTGACAGTGCACATCAGATTGATGAGGTACTACACTTCGACGAATTTTCCCAGAATGAAAGC       AAAGAACCTGACCCTTGTCTGAAAAGCAACAAACAAAAGTGCTGGCTGACAGCTCTCTGGAGGGGGCA       GAAAAAAACGACAGAGCCTCTGGATCAGCAGGCTGGGTCCTTAAACAATGAGAGCGGACTGGTCAGCT       GCTACTTTGGGCAGCTTCTCTCCAAATTAGACAGGATCAAGACTGATTACACACTGAGTATTGCCAAC       AGGCTTTATGGAGAGCAGGAATTCCCAATCTGTCAGGAATACTTAGATGGTGTGATTCAATTTTACCA       CACGACGATTGAAAGTGTTGATTTCCAAAAAAACCCTGAAAAATCCAGACAAGAGATTAACTTCTGGG       TTGAATGTCAATCCCAAGGTAAAATCAAGGAACTCTTCAGCAAGGACGCTATTAATGCTGAGACTGTG       CTGGTACTGGTGAATGCTGTTTACTTCAAGGCCAAATGGGAAACATACTTTGACCATGAAAACACGGT       GGATGCACCTTTCTGTCTAAATGCGAATGAAAACAAGAGTGTGAAGATGATGATGCAAAAAGGCCTCT       ACAGAATTGGCTTCATAGAGGAGGTGAAGGCACAGATCCTGGAAATGAGGTACACCAAGGGGAAGCTC       AGCATGTTCGTGCTGCTGCCATCTCACTCTAAAGATAACCTGAAGGGTCTGGAAGAGCTTGAAAGGAA       AATCACCTATGAAAAAATGGTGGCTGGAGCAGCTCAGAAAACATGTCAGAAGAAATCGGTGGTCCTGT       CCTTCCCCCGGTTCACCCTGGAAGACAGCTATGATCTCAATTCCATTTTACAAGACATGGGCATTACG       GATATCTTTGATGAAACGAGGGCTGATCTTACTGGAATCTCTCCAAGTCCCAATTTGTACTTGTCAAA       AATTATCCACAAAACCTTTGTGGAGGTGGATGAAAACGGTACCCAGGCAGCTGCAGCCACTGGGGCTG       TTGTCTCGGAAAGGTCACTACGATCTTGGGTGGAGTTTAATGCCAACCACCCTTTTCTCTTTTTCATT       AGACACAACAAAACCCAAACCATTCTCTTTTATGGAAGGGTCTGCTCTCCT TAA   AAGGGG                                           NOV23a, CG54308-04                       Protein Sequence   SEQ ID NO: 552   425 aa   MW at 48476.3kD                     MDSLVTANTKFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVLHFDEFSQNES           KEPDPCLKSNKQKVLADSSLEGQKKTTEPLDQQAGSLNNESGLVSCYFGQLLSJHDRIKTDYTLSIAN       RLYGEQEFPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQEINFWVECQSQGKIKELFSKDAINAETV       LVLVNAVYFKAKWETYFDHENTVDAPFCLNANENKSVKMMMQKGLYRIGFIEEVKAQILEMRYTKGKL       SMFVLLPSHSKDNLKGLEELERKITYEKMVAWSSSENMSEESVVLSFPRFTLEDSYDLNSILQDMGIT       DIFDETRADLTGISPSPNLYLSKIIHKTFVEVDENGTQAAAATGAVVSERSLRSWVEFNANHPFLFFI       RHNKTQTILFYGRVCSP                                     NOV23b, CG54308-01   SEQ ID NO: 553   1200 bp           DNA Sequence   ORF Start: ATG at 7   ORF Stop: TAA at 1192                       TTTACA   ATG GACTCTCTTGTTACAGCAAACACCAAATTTTGCTTTGATCTTTTTCAAGAGATAGGCAA           AGATGATCGTCATAAAAACATATTTTTCTCTCCCCTGAGCCTCTCAGCTGCCCTTGGTATGGTACGCT       GAAAGCAAAGAACCTGCTGGGTCCTTAAACAATGAGAGCGGACTGGTCAGCTGCTACTTTGGGCAGCT       TCTCTCCAAATTAGACAGGATCAAGACTGATTACACACTGAGTATTGCCAACAGGCTTTATGGAGAGC       AGGAATTCCCAATCTGTCAGGAATACTTAGATGGTGTGATTCAATTTTACCACACGACGATTGAAAGT       GTTGATTTCCAAAAAAACCCTGAAAAATCCAGACAAGAGATTAACTTCTGGGTTGAATGTCAATCCCA       AGGTAAATCAAGGACCTCTTCAGCAAGGACGCTATTAATGCTGAGACTGTGCTGGTACTGGGTGAATG       CTGTTTACTTCAAGGCCAAATGGGAAACATACTTTGACCATGAAAACACGGTGGATGCACCTTTCTGT       CTAAATCAGAATGAAAACAAGAGTGTGAAGATGATGACGCAAAAAGGCCTCTACAGAATTGGCTTCAT       AGAGGAGGTGAAGGCACAGATCCTGGAAATGAGGTACACCAAGGGGAAGCTCAGCATGTTCGTGCTGC       ATGGTGGCCTGGAGCAGCTCAGAAAACATGTCAGAAGAATCGGTGGTCCTGTCCTTCCCCCGGTTCAC       CCTGGAAGACAGCTATGATCTCAATTCCATTTTACAAGACATGGGCATTACGGATATCTTTGATGAAA       CGAGGGCTGATCTTACTGGAATCTCTCCAAGTCCCAATTTGTACTTGTCAAAAATTATCCACAAAACC       TTTGTGGAGGTGGATGAAAACGGTACCCAGGCAGCTGCAGCCACTGGGGCTGTTGTCTCGGAAAGGTC       AAACCATTCTCTTTTATGGCAGGGTCTGCTCTCCT TAA   AAGGGG                                           NOV23b, CG54308-01                       Protein Sequence   SEQ ID NO: 554   395 aa   MW at 45176.6kD                     MDSLVTANTKFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVLHFNEFSQNES           KEPAGSLNNESGLVSCYFGQLLSKLDRIKTDYTLSIANRLYGEQEFPICQEYLDGVIQFYHTTIESVD       FQKNPEKSRQEINFWVECQSQGKIKDLFSKDAINAETVLVLVNAVYFKAKEWTYFDHENTVDAPFCLN       QNENKSVKMMTQKGLYRIGFIEEVKAQILEMRYTKGKLSMFVLLPSHSKDNLKGLEELERKITYEKMV       AWSSSENMSEESVVLSFPRFTLEDSYDLNSILQDMGITDIFDETRADLTGISPSPNLYLSKIIHKTFV       EVDENGTQAAAATGAVVSERSLRSWVEFNANHPFLFFIRHNKTQTILFYGRVCSP                                     NOV23c, CG54308-02   SEQ ID NO: 555   1278 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     ACCATGGACTCTCTTGTTACAGCAAACACCAAATTTTGCTTTGATCTTTTTCAAGAGATAGGCAAAGA           TGATCGTCATAAAAACATATTTTTCTCTCCCCTGAGCCTCTCAGCTGCCCTTGGTATGGTACGCTTGG       GTGCTAGAAGTGACAGTGCACATCAGATTGATGAGGTACTACACTTCAACGAATTTTCCCAGAATGAA       AGCAAAGAACCTGACCCTTGTCTGAAAGCAACAAACAAAAAGTGCTGGACTGACAGCTCTCTGGAGGG       GCAGAAAAAAACGACAGAGCCTCTGGATCAGCAGGCTGGGTCCTTAAACAATGAGAGcGGACTGGTCA       GCTGCTACTTTGGGCAGCTTCTCTCCAAATTAGACAGGATCAAGACTGATTACACACTGAGTATTGCC       AACAGGCTTTATGGAGGGCAGGAATTCCCAATCTGTCAGGAATACTTAGATGGTGTGATTCAATTTTA       CCACACGACGATTGAAAGTGTTGATTTCCAAAAAAACCCTGAAAAATCCAGACAAGAGATTAACTTCT       GGGTTGAATGTCAATCCCAAGGTAAAATCAAGGAACTCTTCAGCAAGGACGCTATTAATGCTGAGACT       GTGCTGGTACTGGTGAATGCTGTTTACTTCAAGGCCAAATGGGAAACATACTTTGACCATGAAAACAC       GGTGGATGCACCTTTCTGTCTAAATGCGAATGAAAACAAGAGTGTGAAGATGATGACGCAAAAAGGCC       TCTACAGAATTGGCTTCATAGAGGAGGTGAAGGCACAGATCCTGGAAATGAGGTACACCAAGGGGAAG       CTCAGCATGTTCGTGCTGCTGCCATCTCACTCTAAAGATAACCTGAAGGGTCTGGAAGAGCTTGAAAG       GAAAATCACCTATGAAAAAATGGTGGCCTGGAGCAGCTCAGAAAACATGTCAGAAGAATCGGTGGTCC       TGTCCTTCCCCCGGTTCACCCTGGAAGACAGCTATGATCTCAATTCCATTTTACAAGACATGGGCATT       ACGGATATCTTTGATGAAACGAGGGCTGATCTTACTGGAATCTCTCCAAGTCCCAATTTGTACTTGTC       AAAAATTATCCACAAAACCTTTGTGGAGGTGGATGAAAACGGTACCCAGGCAGCTGCAGCCACTGGGG       CTGTTGTCTCGGAAAGGTCACTACGATCTTGGGTGGAGTTTAATGCCAACCACCCTTTTCTCTTTTTC       ATTAGACACAACAAAACCCAAACCATTCTCTTTTATGGCAGGGTCTGCTCTCCT                                         NOV23c, CG54308-02                       Protein Sequence   SEQ ID NO: 556   426 aa   MW at 48474.3kD                     TMDSLVTANTKFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVLHFNEFSQNE           SKEPDPCLKSNKQKVLADSSLEGQKKTTEPLDQQAGSLNNESGLVSCYFGQLLSKLDRIKTDYTLSIA       NRLYGGQEFPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQEINFWVECQSQGKIKELFSKDAINAET       VLVLVNAVYFKAKWETYFDHENTVDAPFCLNANENKSVKMMTQKGLYRIGFIEEVKAQILEMRYTKGK       LSMFVLLPSHSKDNLKGLEELERKITYEKMVAWSSSENMSEESVVLSFPRFTLEDSYDLNSILQDMGI       TDIFDETRADLTGISPSPNLYLSKIIHKTFVEVDENGTQAAAATGAVVSERSLRSWVEFNANHPFLFF       IRHNKTQTILFYGRVCSP                                     NOV23d, CG54308-03   SEQ ID NO: 557   1285 bp           DNA Sequence   ORF Start: ATG at 8   ORF Stop: TAA at 1277                       TTTTACA   ATG GACTCTCTTGTTACAGCAAACACCAAATTTTGCTTTGATCTTTTTCAAGAGATAGGCA           AAGATGATCGTCATAAAAACATATTTTTCTCTCCCCTGAGCCTCTCAGCTGCCCTTGGTATGGTACGC       TTGGGTGCTATAAGTGACAGTGCACATCACATTGATGAGGTACGTGTCCACTATTCCCAGAATGAAAG       CAAAGAACCTGACCCTTGTCTGAAAAGCAACAAACAAAAAGTGCTGGCTGACAGCTCTCTGGAGGGGC       AGAAAAAAACGACAGAGCCTCTGGATCAGCAGGCTGGGTCCTTAAACAATGGGAGCGGACTGGTCAGC       CAGGCTTTATGGAGAGCGGGAATTCCCAATCTGTCAGGAATACTTAGATGGTGTGATTCAATTTTACC       ACACGACGATTGAAAGTGTTGATTTCCAAAAAAACCCTGAAAAATCCAGACAAGAGATTAACTTCTGG       GTTGAATGTCAATCCCAAGGTAAAATCAAGGAACTCTTCAGCAAGGACGCTATTAATGCTGAGACTGT       GCTGGTACTGGTGAATGCTGTTTACTTCAAGGCCAAATGGGAAAACATACTTTGACCATGAAACACGG       TGGATGCACCTTTCTGTCTAAATGCGAATGAAAACAAGAGTGTGAAGATGATGACGCAAAAAGGCCTC       CAGCATGTTCGTGCTGCTGCCATCTCACTCTAAAGATAACCTGAAGGGTCTGGAAGAGCTTGAAAGGA       AAATCACCTATGAAAAAATGGTGGCCTGGAGCAGCTCAGAAAACATGTCAGAAGAATCGGTGGTCCTG       TCCTTCCCCCGGTTCACCCTGGAAGACAGCTATGATCTCAATTCCATTTTACAAGACATGGGCATTAC       GGATATCTTTGATGAAACGAGGGCTGATCTTACTGGAATCTCTCCAAGTCCCAATTTGTACTTGTCAA       AAATTATCCACAAAACCTTTGTGGAGGTGGATGAAAACGGTACCCAGGCAGCTGCAGCCACTGGGGCT       GTTGTCTCGGAAAGGTCACTACGATCTTGGGTGGAGTTTAATGCCAACCACCCTTTTCTCTTTTTCAT       TAGACACAACAAAACCCAAACCATTCTCTTTTATGGAAGGGTCTGCTCTCCT TAA   AAGGGG                                           NOV23d, CG54308-03                       Protein Sequence   SEQ ID NO: 558   423 aa   MW at 48136.0kD                     MDSLVTANTKFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGAISDSAHHIDEVRVHYSQNESKE           PDPCLKSNKQKVLADSSLEGQKKTTEPLDQQAGSLNNGSGLVSCYFGQLLSKLDRIKTDYTLSIADRL       LVNAVYFKAXWETYFDHENTVDAPFCLNANENKSVKMMTQKGLYRIGFIEEVKAQILEMRYTKGKLSM       FVLLPSHSKDNLKGLEELERKITYEKMVAWSSSENMSEESVVLSFPRFTLEDSYDLNSILQDMGITDI       FDETRADLTGISPSPNLYLSKIIHKTFVEVDENGTQAAAATGAVVSERSLRSWVEFNANHPFLFFIRH       NKTQTILFYGRVCSP                                     NOV23e, CG54308-05   SEQ ID NO: 559   1196 bp           DNA Sequence   ORF Start: ATG at 60   ORF Stop: TAA at 1155                       CCAATCACCATTTTCTCTTTCTCCTTTTTTTTTGGTTTTAGATCGTTATAAGTTTTACA   ATG GACTCT           CTTGTTACAGCAAACACCAAATTTTGCTTTGATCTTTTTCAAGAGATAGGCAAAGATGATCGTCATAA       AAACATATTTTTCTCTCCCCTGAGCCTCTCAGCTGCCCTTGGTATGGTACGCTTGGGTGCTAGAAGTG       ACAGTGCACATCAGATTGATGAGGTACGTTCCTTAAACAATGAGAGCGGACTGGTCAGCTGCTACTTT       GGGCAGCTTCTCTCCAAATTAGACAGGATCAAGACTGATTACACACTGAGTATTGCCAACAGGCTTTA       TGGAGAGTCCAGCCTGGGAGACAAGAGCGAAACTCTGTCTCAAAAAAAAAAAAAAAAAATTATCTACA       CAAATGCTTTTGATACAATTCATACTCAGGATATTCTCTGGGATCTTTTTTTTAGGTAAATCAAGGAA       CTCTTCAGCAAGGACGCTATTAATGCTGAGACTGTGCTGGTACTGGTGATTGCTGTTTACTTCAAGGC       CAAATGGGAACATACTTTGACCATGAAAACACGGTGGATGCACCTTTCTGTCTLAATCAGAATGAAAA       ACAAGAGTGTGAAGATGATGACGCAAAAAGGCCTCTACAGAATTGGCTTCATAGAGGAGGTGAAGGCA       CAGATCCTGGAAATGAGGTACACCAAGGGGAAGCTCAGCATGTTCGTGCTGCTGCCATCTCACTCTAA       AGATAACCTGAAGGGTATCACCTATGAAAAAATGGTGGCCTGGAGCAGCTCAGAAAACATGTCAGAAG       AATCGGTGGTCCTGTCCTTCCCCCGGTTCACCCTGGAAGACAGCTATGATCTCAATTCCATTTTACAA       GACATGGGCATTACGGATATCTTTGATGAAACGAGGGCTGATCTTACTGGAATCTCTCCAAGTCCCAA       TTTGTACTTGTCAAAAATTATCCACAAAACCTTTGTGGAGGTGGATGAAAACGGTACCCAGGCAGCTG       CAGCCACTGGGGCTGTTGTCTCGGAAAGGTCACTACGATCTTGGGTGGAGTTTAATGCCAACCACCCT       TTTCTCTTTTTCATTAGACACAACAAAACCCAAACCATTCTCTTTTATGGCAGGGTCTGCTCTCCT TA           A   AAGGGGAGCAGTGTCTAGTACTTTGGAGCTGGAGGAAAA                                           NOV23e,                       Protein Sequence   SEQ ID NO: 560   365 aa   MW at 41476.8kD                     MDSLVTANTKFCFDLFQEIGKDDRhKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVRSLNNESGLVS           CYFGQLLSKLDRIKTDYTLSIANPLYGESSLGDKSETLSQKKKKKIIYTNAFDTIHTQDILWDLFLGK       IKELFSKDAINAETVLVLVNAVYFKACWETYFDHENTVDAPFCLNQNENKSVKMMTQKGLYRIGFIEE       VKAQILEMRYTKGKLSMFVLLPSHSKDNLKGITYEKMVAWSSSENMSEESVVLSFPRFTLEDSYDLNS       ILQDMGITDIFDETPADLTGISPSPNLYLSKIIHKTFVEVDENGTQAAAATGAVVSERSLRSWVEFNA       NHPFLFFIRHNKTQTILFYGRVCSP                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 23B.  
                   TABLE 23B                       Comparison of the NOV23 protein sequences.                                            NOV23a   -MDSLVTANTKFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVLH           NOV23b   -MDSLVTANTKFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVLH       NOV23c   TMDSLVTANTKFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVLH       NOV23d   -MDSLVTANTKFCFDLFQEIGKDDRHKNIFFSPLSLSAAIGMVRLGAISDSAHHIDEVR-       NOV23e   -MDSLVTANTKFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVR-               NOV23a   FDEFSQNESKEPDPCLKSNKQKVLADSSLEGQKKTTEPLDQQAGSLNNESGLVSCYFGQL       NOV23b   FNEFSQNESKEP------------------------------AGSLNNESGLVSCYFGQL       NOV23c   FNEFSQNESKEPDPCLKSNKQKVLADSSLEGQKKTTEPLDQQAGSLNNESGLVSCYFGQL       NOV23d   -VHYSQNESKEPDPCLKSNKQKVLADSSLEGQKKTTEPLDQQAGSLNNGSGLVSCYFGQL       NOV23e   --------------------------------------------SLNNESGLVSCYFGQL               NOV23a   LSKLDRIKTDYTLSIANRLYGEQEFPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQEIN       NOV23b   LSKLDRIKTDYTLSIANRLYGEQEFPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQEIN       NOV23c   LSKLDRIKTDYTLSIANRLYGGQEFPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQEIN       NOV23d   LSKLDRIKTDYTLSIADRLYGEREFPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQEIN       NOV23e   LSKLDRIKTDYTLSIANRLYGESSLGDKSETLS------QKKKKKIIYThAFDTIHTQDI               NOV23a   FWVECQSQGKIKELFSKDAINAETVLVLVNAVYFKAKWETYFDHENTVDAPFCLNANENK       NOV23b   FWVECQSQGKIKDLFSKDAINAETVLVLVNAVYFKAKWETYFDHENTVDAPFCLNQNENK       NOV23c   FWVECQSQGKIKELFSKDAINAETVLVLVNAVYFKAKWETYFDHENTVDAPFCLNANENK       NOV23d   FWVECQSQGKIKELFSKDAINAETVLVLVNAVYFKAKWETYFDHENTVDAPFCLNANENK       NOV23e   LWDLF--LGKIKELFSKDAINAETVLVLVNAVYFKAKWETYFDHENTVDAPFCLNQNENK               NOV23a   SVKMMMQKGLYRIGFIEEVKAQILEMRYTKGKLSMFVLLPSHSKDNLKGLEELERKITYE       NOV23b   SVKMMTQKGLYRIGFIEEVKAQILENRYTKGKLSMFVLLPSHSKDNLKGLEELERKITYE       NOV23c   SVKNMTQKGLYRIGFIEEVKAQILEMRYTKGKLSMFVLLPSHSKDNLKGLEELERKITYE       NOV23d   SVKMMTQKGLYRIGFIEEVKAQILEMRYTKGKLSMFVLLPSHSKDNLKGLEELERKITYE       NOV23e   SVKMMTQKGLYRIGFIEEVKAQILEMRYTKGKLSMFVLLPSHSKDNLKG-------ITYE               NOV23a   KMVAWSSSENMSEESVVLSFPRFTLEDSYDLNSILQDMGITDIFDETRADLTGISPSPNL       NOV23b   KMVAWSSSENMSEESVVLSFPRFTLEDSYDLNSILQDMGITDIFDETRADLTGISPSPNL       NOV23c   KMVAWSSSENMSEESVVLSFPRFTLEDSYDLNSILQDMGITDIFDETRADLTGISPSPNL       NOV23d   KMVAWSSSENMSEESVVLSFPRFTLEDSYDLNSILQDMGITDIFDETRADLTGISPSPNL       NOV23e   KMVAWSSSENMSEESVVLSFPRFTLEDSYDLNSILQDMGITDIFDETRADLTGISPSPNL               NOV23a   YLSKIIHKTFVEVDENGTQAAAATGAVVSERSLRSWVEFNANHPFLFFIRHNKTQTILFY       NOV23b   YLSKIIHKTFVEVDENGTQAAAATGAVVSERSLRSWVEFNANHPFLFFIRHNKTQTILFY       NOV23c   YLSKIIHKTFVEVDENGTQAAAATGAVVSERSLRSWVEFNANHPFLFFIRHNKTQTILFY       NOV23d   YLSKIIHKTFVEVDENGTQAAAATGAVVSERSLRSWVEFNANHPFLFFIRHNKTQTILFY       NOV23e   YLSKIIHKTFVEVDENGTQAAAATGAVVSERSLRSWVEFNANHPFLFFIPHNKTQTILFY               NOV23a   GRVCSP       NOV23b   GRVCSP       NOV23c   GRVCSP       NOV23d   GRVCSP       NOV23e   GRVCSP               NOV23a   (SEQ ID NO: 552)       NOV23b   (SEQ ID NO: 554)       NOV23c   (SEQ ID NO: 556)       NOV23d   (SEQ ID NO: 558)       NOV23e   (SEQ ID NO: 560)                  
 
      Further analysis of the NOV23a protein yielded the following properties shown in Table 23C.  
               TABLE 23C                       Protein Sequence Properties NOV23a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 10; pos. chg 1; neg. chg 1           H-region:   length 3; peak value −2.92           PSG score:   −7.33                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −2.16           possible cleavage site: between 40 and 41                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 0                             PERIPHERAL   Likelihood = 3.07 (at 197)                         ALOM score: 0.42 (number of TMSs: 0)       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment (75):   7.00           Hyd Moment (95):   3.76   G content:   0           D/E content:   2   S/T content:   3                         Score: −6.29       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 10.8%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear           discrimination           Prediction: cytoplasmic           Reliability: 70.6       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         47.8%: mitochondrial           30.4%: cytoplasmic           17.4%: nuclear            4.3%: vacuolar                 &gt;&gt; prediction for CG54308-04 is mit (k = 23)                  
 
      A search of the NOV23a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 23D.  
               TABLE 23D                          Geneseq Results for NOV23a                                         NOV23a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               ABG70630   Amino acid sequence for novel human   1 . . . 425   423/425 (99%)   0.0           thypin -  Homo sapiens , 425 aa.   1 . . . 425   424/425 (99%)           [WO200272769-A2, 19-SEP-2002]       ABB53280   Human polypeptide #20 -  Homo      1 . . . 425   392/425 (92%)   0.0             sapiens , 394 aa. [WO200181363-A1,   1 . . . 394   393/425 (92%)           01-NOV-2001]       AAM47207   Human NOV1 protein -  Homo sapiens ,   1 . . . 425   391/425 (92%)   0.0           395 aa. [WO200174851-A2, 11-OCT-2001]   1 . . . 395   393/425 (92%)       ABG28280   Novel human diagnostic protein   1 . . . 394   388/394 (98%)   0.0           #28271 -  Homo sapiens , 617 aa.   109 . . . 502    389/394 (98%)           [WO200175067-A2, 11-OCT-2001]       ABG70294   Human novel polypeptide #10 -  Homo      1 . . . 425   327/425 (76%)   e−172             sapiens , 365 aa. [WO200257452-A2,   1 . . . 365   332/425 (77%)           25-JUL-2002]                  
 
      In a BLAST search of public sequence databases, the NOV23a protein was found to have homology to the proteins shown in the BLASTP data in Table 23E.  
               TABLE 23E                          Public BLASTP Results for NOV23a                                         NOV23a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q96P63   Serpin B12 -  Homo sapiens     1 . . . 425   403/425 (94%)   0.0           (Human), 405 aa.   1 . . . 405   404/425 (94%)       CAD13083   Sequence 1 from Patent   1 . . . 425   391/425 (92%)   0.0           WO0174851 -  Homo sapiens     1 . . . 395   393/425 (92%)           (Human), 395 aa.       Q9D7P9   2300003F07Rik protein (Weakly   1 . . . 425   303/425 (71%)         e−174           similar to serpin B12) -  Mus     1 . . . 423   354/425 (83%)             musculus  (Mouse), 423 aa.       I38202   leupin precursor - human, 390 aa.   1 . . . 425   196/426 (46%)        4e−95               1 . . . 390   267/426 (62%)       P48594   Squamous cell carcinoma antigen 2   1 . . . 425   196/426 (46%)        4e−95           (SCCA-2) (Leupin) -  Homo sapiens     1 . . . 390   267/426 (62%)           (Human), 390 aa.                  
 
      PFam analysis predicts that the NOV23a protein contains the domains shown in the Table 23F.  
               TABLE 23F                          Domain Analysis of NOV23a                                     Identities/           Pfam   NOV23a Match   Similarities for       Domain   Region   the Matched Region   Expect Value               serpin   1 . . . 425   161/441 (37%)   1.9e−147               350/441 (79%)                  
 
     Example 24  
      The NOV24 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 24A.  
                   TABLE 24A                       NOV24 Sequence Analysis                                                NOV24a, CG54764-02   SEQ ID NO: 561   339 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 337                       ATG AGCCCCTTTGGCAGTCTGGCGAAGCTCTTGGGTCCTTCTCAGATTGCATGGTGGTGCATCACGAC           CCTGTGCTGTTTTCCAGAGAGGTATGCTGGACGGGACCATAACAGCTGCAAACTCTCCCAGAGGGGGT       TCCTAAACTTCATGAACACTGTACTGGTTGCCTTCACAAAGAACCAGAAGGGCTCTGGTGCCCTTGAC       TGCATGATGAAGAAACTGGACTTCAACTGTGATGGGCAGCTAGATTTTCAGGACTTTCTCAGTCTTAC       TGATGGTGTAGCTGTGGCTTGCCCTGACTCCTTCATCCCGGCTGGCCATGCCCATGAGAGAATC TGA                                           NOV24a, CG54764-02                       Protein Sequence   SEQ ID NO: 562   112 aa   MW at 12368.1kD                     MSPFGSLAKLLGPSQIAWWCITTLCCFPERYAGRDHNSCKLSQRGFLNFMNTVLVAFTKNQKGSGALD           CMMKKLDFNCDGQLDFQDFLSLTDGVAVACPDSFIPAGHAHERI                                     NOV24b, CG54764-01   SEQ ID NO: 563   348 bp           DNA Sequence   ORF Start: ATG at 5   ORF Stop: TGA at 341                       TGCC   ATG AGCCCCTTTGGCAGTCTGGCGAAGCTCTTGGGTCCTTCTCAGATTGCATGGTGGTGCATCA           CGACCTGTGCTGTTTTCCAGAGAGGGTATGCTGGACGGGACCATAACAGCTGCAAACTCTCCCAGAGG       GGGTTCCTAAACTTCATGAACACTGTACTGGTTGCCTTCACAAAGAACCAGAAGGGCTCTGGTGCCCT       TGACTGCATGATGAAGAAACTGGACTTCAACTGTGATGGGCAGCTAGATTTTCAGGACTTTCTCAGTC       TTACTGATGGTGTAGCTGTGGCTTGCCCTGACTCCTTCATCCCGGCTGGCCATGCCCATGAGAGAATC         TGA   GGTGC                                           NOV24b, 0G54764-01                       Protein Sequence   SEQ ID NO: 564   112 aa   MW at 12281.0kD                     MSPFGSLAKLLGPSQIAWWCITTCAVFQRGYAGRDHNSCKLSQRGFLNFMNTVLVAFTKNQKGSGALD           CMMKKLDFNCDGQLDFQDFLSLTDGVAVACPDSFIPAGHAHERI                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 24B.  
                   TABLE 24B                       Comparison of the NOV24 protein sequences.                                            NOV24a   MSPFGSLAKLLGPSQIAWWCITTLCCFPERYAGRDHNSCKLSQRGFLNFMNTVLVAFTKN           NOV24b   MSPFGSLAKLLGPSQIAWWCITTCAVFQRGYAGRDHNSCKLSQRGFLNFMNTVLVAFTKN               NOV24a   QKGSGALDCMMKKLDFNCDGQLDFQDFLSLTDGVAVACPDSFIPAGHAHERI       NOV24b   QKGSGALDCMMKKLDFNCDGQLDFQDFLSLTDGVAVACPDSFIPAGHAHERI               NOV24a   (SEQ ID NO: 562)       NOV24b   (SEQ ID NO: 564)                  
 
      Further analysis of the NOV24a protein yielded the following properties shown in Table 24C.  
               TABLE 24C                       Protein Sequence Properties NOV24a                                        SignalP analysis:   Cleavage site between residues 33 and 34       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 9; pos. chg 1; neg. chg 0           H-region:   length 19; peak value 9.43           PSG score:   5.03                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −5.43           possible cleavage site: between 28 and 29                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 0           number of TMS(s) . . . fixed                             PERIPHERAL   Likelihood = 3.18 (at 87)                         ALOM score: 3.18 (number of TMSs: 0)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 6           Charge difference: 0.0 C(1.0)-N(1.0)           N &gt;= C: N-terminal side will be inside       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment (75):   0.38           Hyd Moment (95):   3.15   G content:   2           D/E content:   1   S/T content:   5                         Score: −5.58       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 8.9%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear           discrimination           Prediction: cytoplasmic           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         43.5%: cytoplasmic           21.7%: mitochondrial           21.7%: nuclear            4.3%: extracellular, including cell wall            4.3%: vacuolar            4.3%: endoplasmic reticulum                 &gt;&gt; prediction for CG54764-02 is cyt (k = 23)                  
 
      A search of the NOV24a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 24D.  
               TABLE 24D                          Geneseq Results for NOV24a                                         NOV24a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value                                             AAE16342   Human calgizzarin-like-like protein,   1 . . . 112   106/112   (94%)   4e−59           POLY6 -  Homo sapiens , 112 aa.   1 . . . 112   106/112   (94%)           [WO200185767-A2, 15-NOV-2001]       AAG65905   Amino acid sequence of GSK gene Id   7 . . . 112   100/106   (94%)   2e−57           35812 -  Homo sapiens , 106 aa.   1 . . . 106   104/106   (97%)           [WO200172961-A2, 04-OCT-2001]       AAG65904   Amino acid sequence of GSK gene Id   20 . . . 108    88/89   (98%)   2e−47           35812 -  Homo sapiens , 114 aa.   26 . . . 113    88/89   (98%)           [WO200172961-A2, 04-OCT-2001]       AAB58356   Lung cancer associated polypeptide   6 . . . 111   54/106   (50%)   6e−22           sequence SEQ ID 694 -  Homo sapiens ,   29 . . . 133    73/106   (67%)           134 aa. [WO200055180-A2, 21-SEP-2000]       ABG96407   Human ovarian cancer marker M471 -   7 . . . 111   54/105   (51%)   7e−22             Homo sapiens , 105 aa.   1 . . . 104   72/105   (68%)           [WO200271928-A2, 19-SEP-2002]                  
 
      In a BLAST search of public sequence databases, the NOV24a protein was found to have homology to the proteins shown in the BLASTP data in Table 24E.  
               TABLE 24E                          Public BLASTP Results for NOV24a                                         NOV24a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             P50543   Calgizzarin (Endothelial monocyte-   20 . . . 103   52/84   (61%)   9e−24           activating polypeptide) (EMAP) -  Mus      8 . . . 91    65/84   (76%)             musculus  (Mouse), 98 aa.       P24480   Calgizzarin (S100C protein) -   20 . . . 111   53/92   (57%)   1e−22             Oryctolagus cuniculus  (Rabbit), 102   10 . . . 101   66/92   (71%)           aa.       BAC56502   Similar to S100 calcium-binding    7 . . . 110   55/104   (52%)   2e−22           protein A11 -  Bos taurus  (Bovine), 103    1 . . . 103   73/104   (69%)           aa (fragment).       P31950   Calgizzarin (S100C protein) -  Sus      20 . . . 103   50/84   (59%)   2e−21             scrofa  (Pig), 99 aa.   11 . . . 94    63/84   (74%)       P31949   Calgizzarin (S100C protein) (MLN 70) -    7 . . . 111   54/105   (51%)   2e−21             Homo sapiens  (Human), 105 aa.    1 . . . 104   72/105   (68%)                  
 
      PFam analysis predicts that the NOV24a protein contains the domains shown in the Table 24F.  
               TABLE 24F                          Domain Analysis of NOV24a                                             Identities/               Pfam   NOV24a   Similarities for   Expect           Domain   Match Region   the Matched Region   Value                       S_100   20 . . . 60   11/44 (25%)   0.23                   28/44 (64%)           efhand   66 . . . 94    7/29 (24%)   0.22                   22/29 (76%)                      
 
     Example 25  
      The NOV25 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 25A.  
                   TABLE 25A                       NOV25 Sequence Analysis                                                NOV25a, CG55033-04   SEQ ID NO: 565   1722 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAG at 1591                       ATG AAGCTGTGGATTCATCTCTTTTATTCATCTCTCCTTGCCTGTATATCTTTACACTCCCAAACTCC           AGTGCTCTCATCCAGAGGCTCTTGTGATTCTCTTTGCAATTGTGAGGAAAAAGATGGCACAATGCTAA       TAAATTGTGAAGCAAAAGGTATCAAGATGGTATCTGAAATAAGTGTGCCACCATCACGACCTTTCCAA       CTAAGCTTATTAAATAACGGCTTGACGATGCTTCACACAAATGACTTTTCTGGGCTTACCAATGCTAT       TTCAATACACCTTGGATTTAACAATATTGCAGATATTGAGATAGGTGCATTTAATGGCCTTGGCCTCC       TGAAACAACTTCATATCAATCACAATTCTTTAGAAATTCTTAAAGAGGATACTTTCCATGGACTGGAA       CAACAGACTCAAAGTGTTAATTTTAAATGACAATGCTATTGAGAGTCTTCCTCCAAACATCTTCCGAT       TTGTTCCTTTAACCCATCTAGATCTTCGTGGAAATCAATTACAAACATTGCCTTATGTTGGTTTTCTC       GAACACATTGGCCGAATATTGGATCTTCAGTTGGAGGACAACAAATGGGCCTGCAATTGTGACTTATT       GCAGTTAAAAACTTGGTTGGAGAACATGCCTCCACAGTCTATAATTGGTGATGTTGTCTGCAACAGCC       CTCCATTTTTTAAAGGAAGTATACTCAGTAGACTAAAGAAGGAATCTATTTGCCCTACTCCACCAGTG       TATGAAGAACATGAGGATCCTTCAGGATCATTACATCTGGCAGCAACATCTTCAATAAATGATAGTCG       CATGTCAACTAAGACCACGTCCATTCTAAAACTACCCACCAAAGCACCAGGTTTGATACCTTATATTA       CAAAGCCATCCACTCAACTTCCAGGACCTTACTGCCCTATTCCTTGTAACTGCAAAGTCCTATCCCCA       TCAGGACTTCTAATACATTGTCAGGAGCGCAACATTGAAAGCTTATCAGATCTGAGACCTCCTCCGCA       AAATCCTAGAAAGCTCATTCTAGCGGGAAATATTATTCACAGTTTAATGAAGAGTCCATCCTTTGGTC       CAAAGCATCTGGAAGAGGAAGAAGAGAGGAATGAGAAAGAAGGAAGTGATGCAAAACATCTCCAAAGA       AGTCTTTTGGAACAGGAAAATCATTCACCACTCACAGGGTCAAATATGAAATACAAAACCACGAACCA       ATCAACAGAATTTTTATCCTTCCAAGATGCCAGCTCATTGTACAGAAACATTTTAGAAAAAGAAAGGG       AACTTCAGCAACTGGGAATCACAGAATACCTAAGGAAAAACATTGCTCAGCTCCAGCCTGATATGGAG       GGTATTAGTGGAACAGACAAAAAATGAGTATTTTGAACTTAAAGCTAATTTACATGCTGAACCTGACT       ATTTAGAAGTCCTGGAGCAGCAAACA TAG   ATGGAGAGTTTGAGGGCTTTCGCAGAAATGCTGTGATTC           TGTTTTAAGTCCATACCTTGTAAATTAGTGCCTTACGTGAGTGTGTCATCCATCAGAACCTAAGCACA           GCAGTAAACTATGGAGAAAAAA                                           NOV25a, CG55033-04                       Protein Sequence   SEQ ID NO: 566   530 aa   MW at 59730.7kD                     MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQ           LSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLE       NLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFL       EHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPV       YEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSP       SGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSPSFGPKHLEEEEERNEKEGSDAKHLQR       SLLEQENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERELQQLGITEYLRNKIAQLQPDME       AHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLEVLEQQT                                     NOV25b, CG55033-05   SEQ ID NO: 567   2058 bp           Sequence   ORF Start: ATG at 1   ORF Stop: TAG at 1927                       ATG AAGCTGTGGATTCATCTCTTTTATTCATCTCTCCTTGCCTGTATATCTTTACACTCCCAAACTCC           AGTGCTCTCATCCAGAGGCTCTTGTGATTCTCTTTGCAATTGTGAGGAAAAAGATGGCACAATGCTAA       TAAATTGTGAAGCAAAAGGTATCAAGATGGTATCTGAAATAAGTGTGCCACCATCACGACCTTTCCAA       CTAAGCTTATTAAATAACGGCTTGACGATGCTTCACACAAATGACTTTTCTGGGCTTACCAATGCTAT       TTCAATACACCTTGGATTTAACAATATTGCAGATATTGAGATAGGTGCATTTAATGGCCTTGGCCTCC       TGAAACAACTTCATATCAATCACAATTCTTTAGAAATTCTTAAAGAGGATACTTTCCATGGACTGGAA       AACCTGGAATTCCTGCAAGCAGATAACAATTTTATCACAGTGATTGAACCAAGTGCCTTTAGCAAGCT       CAACAGACTCAAAGTGTTAATTTTAAATGACAATGCTATTGAGAGTCTTCCTCCAAACATCTTCCGAT       TTGTTCCTTTAACCCATCTAGATCTTCGTGGAAATCAATTACAAACATTGCCTTATGTTGGTTTTCTC       GCAGTTAAAACTTGGTTGGAGAACATGCCTCCACAGTCTATAATTGGTGATGTTGTCTGCAAACAGCC       CTCCATTTTTTAAAGGAAGTATACTCAGTAGACTAAAGAAGGAATCTATTTGCCCTACTCCACCAGTG       TATGAAGAACATGAGGATCCTTCAGGATCATTACATCTGGCAGCAACATCTTCAATAAATGATAGTCG       CATGTCAACTAAGACCACGTCCATTCTAAACTACCCACCAAAGCACCACAGATTGACCTTGAGAGATA       ACCCCTGGGACTGCTCCTGTGACCTGGTTGGACTGCAGCAATGGATACAAAAGTTAAGCAAGAACACA       GTGACAGATGACATCCTCTGCACTTCCCCCGGGCATCTCGACAAAAAGGAATTGAAAGCCCTAAATAG       CCACTCCTGCAACAACAACAAATACGGCTGATACTATTTTACGATCTCTTACGGACGCTGTGCCACTG       TCTGTTCTAATATTGGGACTTCTGATTATGTTCATCACTATTGTTTTCTGTGCTGCAGGGATAGTGGT       TCTTGTTCTTCACCGCAGGAGAAGATACAAAAAGAAACAAGTAGATGAGCAAATGAGAGACAACAGTC       CTGTGCATCTTCAGTACAGCATGTATGGCCATALAACCACTCATCACACTACTGAAAGACCCTCTGCC       TCACTCTATGAACAGCACATGGTGAGCCCCATGGTTCATGTCTATAGAAGTCCATCCTTTGGTCCAAA       GCATCTGGAAGAGGAAGAAGAGAGGAATGAGAAAGAAGGAAGTGATGCAAAACATCTCCAAAGAAGTC       TTTTGGAACAGGAAAATCATTCACCACTCACAGGGTCAAATATGAAATACAAAACCACGAACCAATCA       ACAGAATTTTTATCCTTCCAAGATGCCAGCTCATTGTACAGAAACATTTTAGAAAAAGAAAGGGAACT       TCAGCAACTGGGAATCACAGAATACCTAAGGAAAAACATTGCTCAGCTCCAGCCTGATATGGAGGCAC       ATTATCCTGGAGCCCACGAAGAGCTGAAGTTAATGGAAACATTAATGTACTCACGTCCAAGGAAGGTA       TTAGTGGAACAGACAAAAAATGAGTATTTTGAACTTAAAGCTAATTTACATGCTGAACCTGACTATTT       AGAAGTCCTGGAGCAGCAAACA TAG   ATGGAGAGTTTGAGGGCTTTCGCAGAAATGCTGTGATTCTGTT           TTAAGTCCATACCTTGTAAATTAGTGCCTTACGTGAGTGTGTCATCCATCAGAACCTAAGCACAGCAG           TAAACTATGGAGAAAAAA                                           NOV25b, CG55033-05                       Protein Sequence   SEQ ID NO: 568   642 aa   MW at 72606.2kD                     MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQ           LSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLE       NLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFL       EHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPV       YEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPQIDLEDNPWDCSCDLVGLQQWIQKLSKNT       VTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPL       SVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSA       SLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQS       TEFLSFQDASSLYRNILEKERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPRKV       LVEQTKNEYFELKANLHAEPDYLEVLEQQT                                     NOV25c, CG55033-01   SEQ ID NO: 569   2397 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAG at 2395                       ATG CTAATAAATTGTGAAGCAAAAGGTATCAAGATGGTATCTGAAATAAGTGTGCCACCATCACGACC           TTTCCAACTAAGCTTATTAAATAACGGCTTGACGATGCTTCACACAAATGACTTTTCTGGGCTTACCA       ATGCTATTTCAATACACCTTGGATTTAACAATATTGCAGATATTGAGATAGGTGCATTTAATGGCCTT       GGCCTCCTGAAACAACTTCATATCAATCACAATTCTTTAGAAATTCTTAAAGAGGATACTTTCCATGG       ACTGGAAAACCTGGAATTCCTGCAAGCAGATAACAATTTTATCACAGTGATTGAACCAAGTGCCTTTA       GCAAGCTCAACAGACTCAAAGTGTTAATTTTAAATGACAATGCTATTGAGAGTCTTCCTCCAAACATC       TTCCGATTTGTTCCTTTAACCCATCTAGATCTTCGTGGAAATCAATTACAAACATTGCCTTATGTTGG       TTTTCTCGAACACATTGGCCGAATATTGGATCTTCAGTTGGAGGACAACAAATGGGCCTGCAATTGTG       ACTTATTGCAGTTAAAAACTTGGTTGGAGAACATGCCTCCACAGTCTATAATTGGTGATGTTGTCTGC       AACAGCCCTCCATTTTTTAAAGGAAGTATACTCAGTAGACTAAAGAAGGAATCTATTTGCCCTACTCC       ACCAGTGTATGAAGAACATGAGGATCCTTCAGGATCATTACATCTGGCAGCAACATCTTCAATAAATG       ATAGTCGCATGTCAACTAAGACCACGTCCATTCTAAAACTACCCACCAAAGCACCAGGTTTGATACCT       TATATTACAAAGCCATCCACTCAACTTCCAGGACCTTACTGCCCTATTCCTTGTAACTGCAAAGTCCT       ATCCCCATCAGGACTTCTAATACATTGTCAGGAGCGCAACATTGAAAGCTTATCAGATCTGAGACCTC       CTCCGCAAAATCCTAGAAAGCTCATTCTAGCGGGAAATATTATTCACAGTTTAATGAAGTCTGATCTA       GTGGAATATTTCACTTTGGAAATGCTTCACTTGGGAAACAATCGTATTGAAGTTCTTGAAGAAGGATC       GTTTATGAACCTAACGAGATTACAAAAACTCTATCTAAATGGTAACCACCTGACCAAATTAAGTAAAG       GCATGTTCCTTGGTCTCCATAATCTTGAATACTTATATCTTGAATACAATGCCATTAAGGAAATACTG       CCAGGAACCTTTAATCCAATGCCTAAACTTAAAGTCCTGTATTTAAATAACAACCTCCTCCAAGTTTT       ACCACCACATATTTTTTCAGGGGTTCCTCTAACTAAGGTAAATCTTAAAACAAACCAGTTTACCCATC       TACCTGTAAGTAATATTTTGGATGATCTTGATTTGCTAACCCAGATTGACCTTGAGGATAACCCCTGG       GACTGCTCCTGTGACCTGGTTGGACTGCAGCAATGGATACAAAAGTTAAGCAAGAACACAGTGACAGA       TGACATCCTCTGCACTTCCCCCGGGCATCTCGACAAAAAGGAATTGAAAGCCCTAAATAGTGAAATTC       TCTGTCCAGGTTTAGTAAATAACCCATCCATGCCAACACAGACTAGTTACCTTATGGTCACCACTCCT       GCAACAACAACAAATACGGCTGATACTATTTTACGATCTCTTACGGACGCTGTGCCACTGTCTGTTCT       AATATTGGGACTTCTGATTATGTTCATCACTATTGTTTTCTGTGCTGCAGGGATAGTGGTTCTTGTTC       TTCACCGCAGGAGAAGATACAAAAAGAAACAAGTAGATGAGCAAATGAGAGACAACAGTCCTGTGCAT       CTTCAGTACAGCATGTATGGCCATAAAACCACTCATCACACTACTGAAAGACCCTCTGCCTCACTCTA       TGAACAGCACATGGTGAGCCCCATGGTTCATGTCTATAGAAGTCCATCCTTTGGTCCAAAGCATCTGG       AAGAGGAAGAAGAGAGGAATGAGAAAGAAGGAAGTGATGCAAAACATCTCCAAAGAAGTCTTTTGGAA       CAGGAAAATCATTCACCACTCACAGGGTCAAATATGAAATACAAAACCACGAACCAATCAACAGAATT       TTTATCCTTCCAAGATGCCAGCTCATTGTACAGAAACATTTTAGAAAAAGAAAGGGAACTTCAGCAAC       TGGGAATCACAGAATACCTAAGGAAAAACATTGCTCAGCTCCAGCCTGATATGGAGGCACATTATCCT       GGAGCCCACGAAGAGCTGAAGTTAATGGAAACATTAATGTACTCACGTCCAAGGAAGGTATTAGTGGA       ACAGACAAAAAATGAGTATTTTGAACTTAAAGCTAATTTACATGCTGAACCTGACTATTTAGAAGTCC       TGGAGCAGCAAACA TAG                                           NOV25c, CG55033-01                       Protein Sequence   SEQ ID NO: 570 798 aa   MW at 90352.1kD                     MLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGL           GLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNI       FRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVC       NSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRNSTKTTSILKLPTKAPGLIP       YITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDL       VEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEIL       PGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPW       DCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTP       ATTTNTADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVH       LQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQRSLLE       QENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERELQQLGITEYLRKNIAQLQPDMEAHYP       GAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLEAEPDYLEVLEQQT                                     NOV25d, 237376826   SEQ ID NO: 571   990 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     CGCGGTACCCCCTGGGACTGCTCCTGTGACCTGGTTGGACTGCAGCAATGGATACAAAAGTTAAGCAA           GAACACAGTGACAGATGACATCCTCTGCACTTCCCCCGGGCATCTCGACAAAAAGGAATTGAAAGCCC       TAAATAGTGAAATTCTCTGTCCAGGTTTAGTAAATAACCCATCCATGCCAACACAGACTAGTTACCTT       ATGGTCACCACTCCTGCAACAACAACAAATACGGCTGATACTATTTTACGATCTCTTACGGACGCTGT       GCCACTGTCTGTTCTAATATTGGGACTTCTGATTATGTTCATCACTATTGTTTTCTGTGCTGCAGGGA       TAGTGGTTCTTGTTCTTCACCGCAGGAGAAGATACAAAAAGAAACAAGTAGATGAGCAAATGAGAGAC       AACAGTCCTGTGCATCTTCAGTACAGCATGTATGGCCATAAAACCACTCATCACACTACTGAAAGACC       CTCTGCCTCACTCTATGAACAGCACATGGTGAGCCCCATGGTTCATGTCTATAGAAGTCCATCCTTTG       AGAAGTCTTTTGGAACAGGAAAATCATTCACCACTCACAGGGTCAAATATGAAATACAAAACCACGAA       CCAATCAACAGAATTTTTATCCTTCCAAGATGCCAGCTCATTGTACAGAAACATTTTAGAAAAAGAAA       GGGAACTTCAGCAACTGGGAATCACAGAATACCTAAGGAAAAACATTGCTCAGCTCCAGCCTGATATG       GAGGCACATTATCCTGGAGCCCACGAAGAGCTGAAGTTAATGGAAACATTAATGTACTCACGTCCAAG       GAAGGTATTAGTGGAACAGACAAAAAATGAGTATTTTGAACTTAAAGCTAATTTACATGCTGAACCTG       ACTATTTAGAAGTCCTGGAGCAGCAAACACTCGAGGCG                                         NOV25d, 237376826                       Protein Sequence   SEQ ID NO: 572   330 aa   MW at 37853.8kD                     RGTPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYL           MVTTPATTTNTADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRD       NSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQ       EAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLEVLEQQTLEA                                     NOV25e, 310658403   SEQ ID NO: 573   1648 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCTCGCGAACCATGCTAATAAATTGTGAAGCAAAAGGTATCAAGATGGTATCTGAAATAAGTGTGC           CACCATCACGACCTTTCCAACTAAGCTTATTAAATAACGGCTTGACGATGCTTCACACAAATGACTTT       TCTGGGCTTACCAATGCTATTTCAATACACCTTGGATTTAACAATATTGCAGATATTGAGATAGGTGC       ATTTAATGGCCTTGGCCTCCTGAAACAACTTCATATCAATCACAATTCTTTAGAAATTCTTAAAGAGG       ATACTTTCCATGGACTGGAAAACCTGGAATTCCTGCAAGCAGATAACAATTTTATCACAGTGATTGAA       CCAAGTGCCTTTAGCAAGCTCAACAGACTCAAAGTGTTAATTTTAAATGACAATGCTATTGAGAGTCT       TCCTCCAAACATCTTCCGATTTGTTCCTTTAACCCATCTAGATCTTCGTGGAAATCAATTACAAACAT       TGCCTTATGTTGGTTTTCTCGAACACATTGGCCGAATATTGGATCTTCAGTTGGAGGACAACAAATGG       GCCTGCAATTGTGACTTATTGCAGTTAAAAACTTGGTTGGAGAACATGCCTCCACAGTCTATAATTGG       TGATGTTGTCTGCAACAGCCCTCCATTTTTTAAAGGAAGTATACTCAGTAGACTAAAGAAGGAATCTA       TTTGCCCTACTCCACCAGTGTATGAAGAACATGAGGATCCTTCAGGATCATTACATCTGGCAGCAACA       TCTTCAATAAATGATAGTCGCATGTCAACTAAGACCACGTCCATTCTAAAACTACCCACCAAAGCACC       AGGTTTGATACCTTATATTACAAAGCCATCCACTCAACTTCCAGGACCTTACTGCCCTATTCCTTGTA       ACTGCAAAGTCCTATCCCCATCAGGACTTCTAATACATTGTCAGGAGCGCAACATTGAAAGCTTATCA       GATCTGAGACCTCCTCCGCAAAATCCTAGAAAGCTCATTCTAGCGGAAAATATTATTCACAGTTTAAT       GAAGTCTGATCTAGTGGAATATTTCACTTTGGAAATGCTTCACTTGGGAAACAATCGTATTGAAGTTC       TTGAAGAAGGATCGTTTATGAACCTAACGAGATTACAAAAACTCTATCTAAATGGTAACCACCTGACC       AAATTAAGTAAAGGCATGTTCCTTGGTCTCCATAATCTTGAATACTTATATCTTGAATACAATGCCAT       TAAGGAAATACTGCCAGGAACCTTTAATCCAATGCCTAAACTTAAAGTCCTGTATTTAAATAACAACC       TCCTCCAAGTTTTACCACCACATATTTTTTCAGGGGTTCCTCTAACTAAGGTAAATCTTAAAACAAAC       CAGTTTACCCATCTACCTGTAAGTAATATTTTGGATGATCTTGATTTACTAACCCAGATTGACCTTGA       GGATAACCCCTGGGACTGCTCCTGTGACCTGGTTGGACTGCAGCAATGGATACAAAAGTTAAGCAAGA       ACACAGTGACAGATGACATCCTCTGCACTTCCCCCGGGCATCTCGACAAAAAGGAATTGAAAGCCCTA       AATAGTGAAATTCTCTGTCCAGGTTTAGTAAATAACCCATCCATGCCAACACAGACTAGTTACCTTAT       GGTCACCGTCGACGGC                                         NOV25e, 310658403                       Protein Sequence   SEQ ID NO: 574   549 aa   MW at 61376.4kD                     TSRTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGA           FNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESL       PPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIG       DVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAP       GLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLM       KSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAI       KEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLE       DNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLM       VTVDG                                     NOV25f, 317980876   SEQ ID NO: 575   1887 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     ACAGTCTATAATTGGTGATGTTGTCTGCAACAGCCCTCCATTTTTTAAAGGAAGTATACTCAGTAGAC           TAAAGAAGGAATCTATTTGCCCTACTCCACCAGTGTATGAAGAACATGAGGATCCTTCAGGATCATTA       TAAAGAAGGAATCTATTTGCCCTACTCCACCAGTGTATGAAGAACATGAGGATCCTTCAGGATCATTA       ACCCACCAAAGCACCAGGTTTGATACCTTATATTACAAAGCCATCCACTCAACTTCCAGGACCTTACT       GCCCTATTCCTTGTAACTGCAAAGTCCTATCCCCATCAGGACTTCTAATACATTGTCAGGAGCGCAAC       ATTGAAAGCTTATCAGATCTGAGACCTCCTCCGCAAAATCCTAGAAAGCTCATTCTAGCGGGAAATAT       TATTCACAGTTTAATGAAGTCTGATCTAGTGGAATATTTCACTTTGGAAATGCTTCACTTGGGAAACA       GGTAACCACCTGACCAAATTAAGTAAAGGCATGTTCCTTGGTCTCCATAATCTTGAATACTTATATCT       ATTTAAATAACAACCTCCTCCAAGTTTTACCACCACATATTTTTTCAGGGGTTCCTCTAACTAAGGTA       CCAGATTGACCTTGAGGATAACCCCTGGGACTGCTCCTGTGACCTGGTTGGACTGCAGCAATGGATAC       AAAAGTTAAGCAAGAACACAGTGACAGATGACATCCTCTGCACTTCCCCCGGGCATCTCGACAAAAAG       GAATTGAAAGCCCTAAATAGTGAAATTCTCTGTCCAGGTTTAGTAAATAACCCATCCATGCCAACACA       GACTAGTTACCTTATGGTCACCACTCCTGCAACAACAACAAATACGGCTGATACTATTTTACGATCTC       TTACGGACGCTGTGCCACTGTCTGTTCTAATATTGGGACTTCTGATTATGTTCATCACTATTGTTTTC       TGTGCTGCAGGGATAGTGGTTCTTGTTCTTCACCGCAGGAGAAGATACAAAAAGAAACAAGTAGATGA       GCAAATGAGAGACAACAGTCCTGTGCATCTTCAGTACAGCATGTATGGCCATAAAACCACTCATCACA       AAAACATCTCCAAAGAAGTCTTTTGGAACAGGAAAATCATTCACCACTCACAGGGTCAAATATGAAAT       ACAAAACCACGAACCAATCAACAGAATTTTTATCCTTCCAAGATGCCAGCTCATTGTACAGAAACATT       TTAGAAAAAGAAAGGGAACTTCAGCAACTGGGAATCACAGAATACCTAAGGAAAAACATTGCTCAGCT       CCAGCCTGATATGGAGGCACATTATCCTGGAGCCCACGAAGAGCTGAAGTTAATGGAAACATTAATGT       ACTCACGTCCAAGGAAGGTATTAGTGGAACAGACAAAAAATGAGTATTTTGAACTTAAAGCTAATTTA       CATGCTGAACCTGACTATTTAGAAGTCCTGGAGCAGCAAACACTCGAGGCG                                         NOV25f, 317980876                       Protein Sequence   SEQ ID NO: 576   629 aa   MW at 71406.5kD                     RGTKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSL           HLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERN       IESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLN       GNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKV       NLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKK       ELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLILGLLIMFITIVF       CAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYR       SPSFGPKHLEEEEERNEKEGSDAKILQRSLLEQENHSPLTGSNNKYKTTNQSTEFLSFQDASSLYRNI       LEKERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANL       HAEPDYLEVLEQQTLEA                                     NOV25g, 318018151   SEQ ID NO: 577   1887 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     CGCGGTACCAAATGGGCCTGCAATTGTGACTTATTGCAGTTAAAAACTTGGTTGGAGAACATGCCCCC           ACAGTCTATAATTGGTGATGTTGTCTGCAACAGCCCTCCATTTTTTAAAGGAAGTATACTCAGTAGAC       TAAAGAAGGAATCTATTTGCCCTACTCCACCAGTGTATGAAGAACATGAGGATCCTTCAGGATCATTA       CATCTGGCAGCAACATCTTCAATAAATGATAGTCGCATGTCAACTAAGACCACGTCCATTCTAAAACT       ACCCACCAAAGCACCAGGTTTGATACCTTATATTACAAAGCCATCCACTCAACTTCCAGGACCTTACT       GCCCTATTCCTTGTAACTGCAAAGTCCTATCCCCATCAGGACTTCTAATACATTGTCAGGAGCGCAAC       ATTGAAAGCTTATCAGATCTGAGAGCCTCCTCCGCAAAATCCTAGAAGCTCATTCTAGCGGGAAATAT       TATTCACAGTTTAATGAAGTCTGATCTAGTGGAATATTTCACTTTGGAAATGCTTCACTTGGGAAACA       ATCGTATTGAAGTTCTTGAAGAAGGATCGTTTATGAACCTAACGAGATTACAAAAACTCTATCTAAAT       GGTAACCACCTGACCAAATTAAGTAAAGGCATGTTCCTTGGTCTCCATAATCTTGAATACTTATATCT       TGAATACAATGCCATTAAGGAAATACTGCCAGGAACCTTTAATCCAATGCCTAAACTTAAAGTCCTGT       ATTTAAATAACAACCTCCTCCAAGTTTTACCACCACATATTTTTTCAGGGGTTCCTCTAACTAAGGTA       AATCTTAAAACAAACCAGTTTACCCATCTACCTGTAAGTAATATTTTGGATGATCTTGATTTACTAAC       CCAGATTGACCTTGAGGATAACCCCTGGGACTGCTCCTGTGACCTGGTTGGACTGCAGCAATGGATAC       AAAAGTTAAGCAAGAACACAGTGACAGATGACATCCTCTGCACTTCCCCCGGGCATCTCGACAAAAAG       GAATTGAAAGCCCTAAATAGTGAAATTCTCTGTCCAGGTTTAGTAAATAACCCATCCATGCCAACACA       GACTAGTTACCTTATGGTCACCACTCCTGCAACAACAACAAATACGGCTGATACTATTTTACGATCTC       TGTGCTGCAGGGATAGTGGTTCTTGTTCTTCACCGCAGGAGAAGATACAAAAAGAAACAAGTAGATGA       GCAAATGAGAGACAACAGTCCTGTGCATCTTCAGTACAGCATGTATGGCCATAAAACCACTCATCACA       CTACTGAAAGACCCTCTGCCTCACTCTATGAACAGCACATGGTGAGCCCCATGGTTCATGTCTATAGA       AGTCCATCCTTTGGTCCAAAGCATCTGGAAGAGGAAGAAGAGAGGAATGAGAAAGAAGGAAGTGATGC       AAAACATCTCCAAAGAAGTCTTTTGGAACAGGAAAATCATTCACCACTTACAGGGTCAAATATGAAAT       ACAAAACCACGAACCAATCAACAGAATTTTTATCCTTCCAAGATGCCAGCTCATTGTACAGAAACATT       TTAGAAAAAGAAAGGGAACTTCAGCAACTGGGAATCACAGAATACCTAAGGAAAAACATTGCTCAGCT       CCAGCCTGATATGGAGGCACATTATCCTGGAGCCCACGAAGAGCTGAAGTTAATGGAAACATTAATGT       ACTCACGTCCAAGGAAGGTATTAGTGGAACAGACAAAAAATGAGTATTTTGAACTTAAAGCTAATTTA       CATGCTGAACCTGACTATTTAGAAGTCCTGGAGCAGCAAACACTCGAGGCG                                         NOV25g, 318018151                       Protein Sequence   SEQ ID NO: 578   629 aa   MW at 71406.5kD                     RGTKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSL           HLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERN       IESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLN       GNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKV       NLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKK       ELKALNSEILCPGLVNNPSMPTQPSYLMVTTPATTTNTADTILRSLTDAVPLSVLILGLLIMFITVIF       CAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYR       SPSFGPKHLEEEEERNEKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNI       LEKERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANL       HAEPDYLEXTLEQQTLEA                                     NOV25h, 318176316   SEQ ID NO: 579   2433 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     CGCGGTACCACCATGCTAATAAATTGTGAAGCAAAAGGTATCAAGATGGTATCTGAAATAAGTGTGCC           ACCATCACGACCTTTCCAACTAAGCTTATTAAATAACGGCTTGACGATGCTTCACACAAATGACTTTT       CTGGGCTTACCAATGCTATTTCAATACACCTTGGATTTAACAATATTGCAGATATTGAGATAGGTGCA       TTTAATGGCCTTGGCCTCCTGAAACAACTTCATATCAATCACAATTCTTTAGAAATTCTTAAAGAGGA       CAAGTGCCTTTAGCAAGCTCAACAGACTCAAAGTGTTAATTTTAAATGACAATGCTATTGAGAGTCTT       CCTCCAAACATCTTCCGATTTGTTCCTTTAACCCATCTAGATCTTCGTGGAAATCAATTACAAACATT       GCCTTATGTTGGTTTTCTCGAACACATTGGCCGAATATTGGATCTTCAGTTGGAGGACAACAAATGGG       CCTGCAATTGTGACTTATTGCAGTTAAAAACTTGGTTGGAGAACATGCCTCCACAGTCTATAATTGGT       CTTCAATAAATGATAGTCGCATGTCAACTAAGACCACGTCCATTCTAAAACTACCCACCAAAGCACCA       CCTGCAAAGTCCTATCCCCATCAGGACTTCTAATACATTGTCAGGAGCGCAACATTGAAGCTTATCAG       GATGTTGTCTGCAACAGCCCTCCATTTTTTAAAGGAAGTATACTCAGTAGACTAAAGAAGGAATCTAT       TTGCCCTACTCCACCAGTGTATGAAGAACATGAGGATCCTTCAGGATCATTACATCTGGCAGCAACAT       CTTCAATAAATGATAGTCGCATGTCAACTAAGACCACGTCCATTCTAAAACTACCCACCAAAGCACCA       GGTTTGATACCTTATATTACAAAGCCATCCACTCAACTTCCAGGACCTTACTGCCCTATTCCTTGTAA       CTGCAAAGTCCTATCCCCATCAGGACTTCTAATACATTGTCAGGAGCGCAACATTGAAAGCTTATCAG       ATCTGAGACCTCCTCCGCAAAATCCTAGAAAGCTCATTCTAGCGGGAAATATTATTCACAGTTTAATG       AAGTTTACCCATCTACCTGTAAGTAATATTTTGGATGATCTTGATTTACTACCCAGATTGACCTTGAG       TGAAGAAGGATCGTTTACGAACCTAACGAGATTACAAAAACTCTATCTAAATGGTAACCACCTGACCA       AATTAAGTAAAGGCATGTTCCTTGGTCTCCATAATCTTGAATACTTATATCTTGAATACAATGCCATT       AAGGAAATACTGCCAGGAACCTTTAATCCAATGCCTAAACTTAAAGTCCTGTATTTAAATAACAACCT       GTCACCACTCCTGCAACAACAACAAATACGGCTGATACTATTTTACGATCTCTTACGGACGCTGTGCC       ACTGTCTGTTCTAATATTGGGACTTCTGATTATGTTCATCACTATTGTTTTCTGTGCTGCAGGGATAG       TGGTTCTTGTTCTTCACCGCAGGAGAAGATACAAGAAGAAACAAGTAGATGAGCAAATGAGAGACAAC       AGTCCTGTGCATCTTCAGTACAGCATGTATGGCCATAAAACCACTCATCACACTACTGAAAGACCCTC       TGCCTCACTCTATGAACAGCACATGGTGAGCCCCATGGTTCATGTCTATAGAAGTCCATCCTTTGGTC       CAAAGCATCTGGAAGAGGAAGAAGAGAGGAATGAGAAAGAAGGAAGTGATGCAAAACATCTCCAAAGA       AGTCTTTTGGAACAGGAAAATCATTCACCACTCACAGGGTCAAATATGAAATACAAAACCACAGAACC       ATCAACAGAATTTTTATCCTTCCAAGATGCCAGCTCATTGTACAGAAACATTTTAGAAAAAGAAAGGG       AACTTCAGCAACTGGGAATCACAGAATACCTAAGGAAAAACATTGCTCAGCTCCAGCCTGATATGGAG       GCACATTATCCTGGAGCCCACGAAGAGCTGAAGTTAATGGAAACATTAATGTACTCACGTCCAAGGAA       GGTATTAGTGGAGCAGACAAAAAATGAGTATTTTGAACTTAAAGCTAATTTACATGCTGAACCTGACT       ATTTAGAAGTCCTGGAGCAGCAAACACTCGAGGCGAAGGGCGAATTCCAGCAC                                         NOV25h, 318176316                       Protein Sequence   SEQ ID NO: 580   811 aa   MW at 91777.6kD                     RGTTMLINCEAKGIKMVSIESVPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGA           FNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESL       PPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIG       DVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAP       GLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLM       KSDLVEYFTLEMLHLGNNRIEVLEEGSFTNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAI       KEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLE       DNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYTM       VTTPATTTNTADTILRSLTDAVPLSVTILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDN       SPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQR       SLLEQENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERELQQLGITEYLRKNIAQLQPDME       AHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLEVLEQQTLEAKGEFQH                                     NOV25i, CG55033-02   SEQ ID NO: 581   1668 bp           DNA Sequence   ORF Start: ATG at 1   ORE Stop: at 1627                       ATG CTAATAAATTGTGAAGCAAAAGGTATCAAGATGGTATCTGAAATAAGTGTGCCACCATCACGACC           TTTCCAACTAAGCTTATTAAATAACGGCTTGACGATGCTTCACACAAATGACTTTTCTGGGCTTACCA       ATGCTATTTCAATACACCTTGGATTTAACAATATTGCAGATATTGAGATAGGTGCATTTAATGGCCTT       GGCCTCCTGAAACAACTTCATATCAATCACAATTCTTTAGAAATTCTTAAAGAGGATACTTTCCATGG       ACTGGAAAACCTGGAATTCCTGCAAGCAGATAACAATTTTATCACAGTGATTGAACCAAGTGCCTTTA       GCAAGCTCAACAGACTCAAAGTGTTAATTTTAAATGACAATGCTATTGAGAGTCTTCCTCCAAACATC       TTCCGATTTGTTCCTTTAACCCATCTAGATCTTCGTGGAAATCAATTACAAACATTGCCTTATGTTGG       TTTTCTCGAACACATTGGCCGAATATTGGATCTTCAGTTGGAGGACAACAAATGGGCCTGCAATTGTG       ACTTATTGCAGTTAAAAACTTGGTTGGAGAACATGCCTCCACAGTCTATAATTGGTGATGTTGTCTGC       AACAGCCCTCCATTTTTTAAAGGAATATACTCAGTAGACTAAAGAAGGAATCTATTTGCCCATACTCC       ACCAGTGTATGAAGAACATGAGGATCCTTCAGGATCATTACATCTGGCAGCAACATCTTCAATAAATG       ATAGTCGCATGTCAACTAAGACCACGTCCATTCTAAAACTACCCACCAAAGCACCAGGTTTGATACCT       TATATTACAAAGCCATCCACTCAACTTCCAGGACCTTACTGCCCTATTCCTTGTAACTGCAAAGTCCT       ATCCCCATCAGGACTTCTAATACATTGTCAGGAGCGCAACATTGAAAGCTTATCAGATCTGAGACCTC       CTCCGCAAAATCCTAGAAAGCTCATTCTAGCGGGAAATATTATTCACAGTTTAATGAAGTCTGATCTA       GTGGAATATTTCACTTTGGAAATGCTTCACTTGGGAAACAATCGTATTGAAGTTCTTGAAGAAGGATC       GTTTATGAACCTAACGAGATTACAAAAACTCTATCTAAATGGTAACCACCTGACCAAATTAAGTAAAG       GCATGTTCCTTGGTCTCCATAATCTTGAATACTTATATCTTGAATACAATGCCATTAAGGAAATACTG       CCAGGAACCTTTAATCCAATGCCTAAACTTAAAGTCCTGTATTTAAATAACAACCTCCTCCAAGTTTT       ACCACCACATATTTTTTCAGGGGTTCCTCTAACTAAGGTAAATCTTAAAACAAACCAGTTTACCCATC       TACCTGTAAGTAATATTTTGGATGATCTTGATTTGCTAACCCAGATTGACCTTGAGGATAACCCCTGG       GACTGCTCCTGTGACCTGGTTGGACTGCAGCAATGGATACAAAAGTTAAGCAAGAACACAGTGACAGA       TGACATCCTCTGCACTTCCCCCGGGCATCTCGACAAAAAGGAATTGAAAGCCCTAAATAGTGAAATTC       TCTGTCCAGGTTTAGTAAATAACCCATCCATGCCAACACAGACTAGTTACCTTATGGTCACCACT CCT           GCAACAACAACAAATACGGCTGATACTATTTTACGA                                           NOV25i, CG55033-02                       Protein Sequence   SEQ ID NO: 582   542 aa   MW at 60659.6kD                     MLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGL           GLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNI       FRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVC       NSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIP       YITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRXLILAGNIIHSLMKSDL       VEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEIL       PGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPW       DCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVT                                     NOV25j, CG55033-03   SEQ ID NO: 583   1668 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: end of sequence                       ATG CTAATAAATTGTGAAGCAAAAGGTATCAAGATGGTATCTGAAATAAGTGTGCCACCATCACGACC           TTTCCAACTAAGCTTATTAAATAACGGCTTGACGATGCTTCACACAAATGACTTTTCTGGGCTTACCA       ATGCTATTTCAATACACCTTGGATTTAACAATATTGCAGATATTGAGATAGGTGCATTTAATGGCCTT       GGCCTCCTGAAACAACTTCATATCAATCACAATTCTTTAGAAATTCTTAAAGAGGATACTTTCCATGG       ACTGGAAAACCTGGAATTCCTGCAAGCAGATAACAATTTTATCACAGTGATTGAACCAAGTGCCTTTA       GCAAGCTCAACAGACTCAAAGTGTTAATTTTAAATGACAATGCTATTGAGAGTCTTCCTCCAAACATC       TTCCGATTTGTTCCTTTAACCCATCTAGATCTTCGTGGAAATCAATTACAAACATTGCCTTATGTTGG       TTTTCTCGAACACATTGGCCGAATATTGGATCTTCAGTTGGAGGACAACAAATGGGCCTGCAATTGTG       ACTTATTGCAGTTAAAAACTTGGTTGGAGAACATGCCTCCACAGTCTATAATTGGTGATGTTGTCTGC       AACAGCCCTCCATTTTTTAAAGGAAGTATACTCAGTAGACTAAAGAAGGAATCTATTTGCCCTACTCC       ACCAGTGTATGAAGAACATGAGGATCCTTCAGGATCATTACATCTGGCAGCAACATCTTCAATAAATG       ATAGTCGCATATCAACTAAGACCACGTCCATTCTAAAACTACCCACCAAGGCACCAGGTTTGATACCT       TATATTACAAAGCCATCCACTCAACTTCCAGGACCTTACTGCCCTATTCCTTGTAACTGCAAAGTCCT       ATCCCCATCAGGACTTCTAATACATTGTCAGGAGCGCAACATTGAAAGCTTATCAGATCTGAGACCTC       CTCCGCAAAATCCTAGAAAGCTCATTCTAGCGGGAAATATTATTCACAGTTTAATGAAGTCTGATCTA       GTGGAATATTTCACCTTGGAAATGCTTCACTTGGGAAACAATCGTATTGAAGTTCTTGAAGAAGGATC       GTTTATGAACCTAACGAGATTACAAAAACTCTATCTAAATGGTAACCACCTGACCAAATTAAGTAAAG       GCATGTTCCTTGGTCTCCATAATCTTGAATACTTATATCTTGAATACAATGCCATTAAGGAAATACTG       CCAGGAACCTTTAATCCAATGCCTAAACTTAAAGTCCTGTATTTAAATAACAACCTCCTCCAAGTTTT       TACCTGTAAGTAATATTTTGGATGATCTTGATTTACTAACCCAGATTGACCTTGAGGATAACCCCTGG       GACTGCTCCTGTGACCTGGTTGGACTGCAGCAATGGATACAAAAGTTAAGCAAGAACACAGTGACAGA       TCTGTCCAQGTTTAGTAAATAACCCATCCATGCCAACACAGACTAGTTACCTTATGGTCACCACTCCT       GCAACAACAACAAATACGGCTGATACTATTTTACGA                                         NOV25j,                       CG55033-03       Sequence   SEQ ID NO: 584   556 aa   MW at 62099.2kD                     MLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIFAFNGL           GLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNPLKVLILNDNAIESLPPNI       FRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVC       NSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRISTKTTSILKLPTKAPGLIP       YITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDL       VEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEIL       PGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPW       DCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTP       ATTTNTADTILR                                     NOV25k, CG5503306   SEQ ID NO: 585   2539 bp           DNA Sequence   ORF Start: ATG at 5   ORF Stop: TAG at 2528                       CAAC   ATG AAGCTGTGGATTCATCTCTTTTATTCATCTCTCCTTGCCTGTATATCTTTACACTCCCAAA           CTCCAGTGCTCTCATCCAGAGGCTCTTGTGATTCTCTTTGCAATTGTGAGGAAAAAGATGGCACAATG       CTAATAAATTGTGAAGCAAAAGGTATCAAGATGGTATCTGAAATAAGTGTGCCACCATCACGACCTTT       CCAACTAAGCTTATTAAATAACGGCTTGACGATGCTTCACACAAATGACTTTTCTGGGCTTACCAATG       CTATTTCAATACACCTTGGATTTAACAATATTGCAGATATTGAGATAGGTGCATTTAATGGCCTTGGC       CTCCTGAAACAACTTCATATCAATCACAATTCTTTAGAAATTCTTAAAGAGGATACTTTCCATGGACT       GGAAAACCTGGAATTCCTGCAAGCAGATAACAATTTTATCACAGTGATTGAACCAAGTGCCTTTAGCA       AGCTCAACAGACTCAAAGTGTTAATTTTAAATGACAATGCTATTGAGAGTCTTCCTCCAAACATCTTC       CGATTTGTTCCTTTAACCCATCTAGATCTTCGTGGAAATCAATTACAAACATTGCCTTATGTTGGTTT       TCTCGAACACATTGGCCGAATATTGGATCTTCAGTTGGAGGACAACAAATGGGCCTGCAATTGTGACT       TATTGCAGTTAAAAACTTGGTTGGAGAACATGCCTCCACAGTCTATAATTGGTGATGTTGTCTGCAAC       AGCCCTCCATTTTTTAAAGGAAGTATACTCAGTAGACTAAAGAAGGAATCTATTTGCCCTACTCCACC       AGTGTATGAAGAACATGAGGATCCTTCAGGATCATTACATCTGGCAGCAACATCTTCAATAAATGATA       GTCGCATGTCAACTAAGACCACGTCCATTCTAAAACTACCCACCAAAGCACCAGGTTTGATACCTTAT       ATTACAAAGCCATCCACTCAACTTCCAGGACCTTACTGCCCTATTCCTTGTAACTGCAAAGTCCTATC       CCCATCAGGACTTCTAATACATTGTCAGGAGCGCAACATTGAAAGCTTATCAGATCTGAGACCTCCTC       CGCAAAATCCTAGAAAGCTCATTCTAGCGGGAAATATTATTCACAGTTTAATGAAGTCTGATCTAGTG       GAATATTTCACTTTGGAAATGCTTCACTTGGGAAACAATCGTATTGAAGTTCTTGAAGAAGGATCGTT       TATGAACCTAACGAGATTACAAAAACTCTATCTAAATGGTAACCACCTGACCAAATTAAGTAAAGGCA       TGTTCCTTGGTCTCCATAATCTTGAATACTTATATCTTGAATACAATGCCATTAAGGAAATACTGCCA       GGAACCTTTAATCCAATGCCTAAACTTAAAGTCCTGTATTTAAATAACAACCTCCTCCAAGTTTTACC       ACCACATATTTTTTCAGGGGTTCCTCTAACTAAGGTAAATCTTAAAACAAACCAGTTTACCCATCTAC       CTGTAAGTAATATTTTGGATGATCTTGATTTACTAACCCAGATTGACCTTGAGGATAACCCCTGGGAC       TGCTCCTGTGACCTGGTTGGACTGCAGCAATGGATACAAAAGTTAAGCAAGAACACAGTGACAGATGA       CATCCTCTGCACTTCCCCCGGGCATCTCGACAAAAAGGAATTGAAAGCCCTAAATAGTGAAATTCTCT       GTCCAGGTTTAGTAAATAACCCATCCATGCCAACACAGACTAGTTACCTTATGGTCACCACTCCTGCA       ACAACAACAAATACGGCTGATACTATTTTACGATCTCTTACGGACGCTGTGCCACTGTCTGTTCTAAT       ATTGGGACTTCTGATTATGTTCATCACTATTGTTTTCTGTGCTGCAGGGATAGTGGTTCTTGTTCTTC       ACCGCAGGAGAAGATACAAAAAGAAACAAGTAGATGAGCAAATGAGAGACAACAGTCCTGTGCATCTT       CAGTACAGCATGTATGGCCATAAAACCACTCATCACACTACTGAAAGACCCTCTGCCTCACTCTATGA       ACAGCACATGGTGAGCCCCATGGTTCATGTCTATAGAAGTCCATCCTTTGGTCCAAAGCATCTGGAAG       AGGAAGAAGAGAGGAATGAGAAAGAAGGAAGTGATGCAAAACATCTCCAAAGAAGTCTTTTGGAACAG       GAAAATCATTCACCACTCACAGGGTCAAATATGAAATACAAAACCACGAACCAATCAACAGAATTTTT       ATCCTTCCAAGATGCCAGCTCATTGTACAGAAACATTTTAGAAAAAGAAAGGGAACTTCAGCAACTGG       GAATCACAGAATACCTAAGGAAAAACATTGCTCAGCTCCAGCCTGATATGGAGGCACATTATCCTGGA       GACAAAAAATGAGTATTTTGAACTTAAAGCTAATTTACATGCTGAACCTGACTATTTAGAAGTCCTGG       AGCAGCAAACA TAG   ATGGAGAGT                                           NOV25k, CG55033-06                       Protein Sequence   SEQ ID NO: 586   841 aa   MW at 95108.5kD                     MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQ           LSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLE       NLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFL       EHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPV       YEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSP       SGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFM       NLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKSLYLNNNLLQVLPP       HIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDI       LCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLIL       GLLIMFITIVFCAAGIVVLVLHRPRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSASLYEQ       HMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLS       FQDASSLYRNILEKERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQT       KNEYFELKANLHAEPDYLVELEQQT                                     NOV25l, CG55033-07   SEQ ID NO: 587   1648 bp           DNA Sequence   ORF Start: ATG at 14   ORF Stop: at 1640                       CACCTCGCGAACC   ATG CTAATAAATTGTGAAGCAAAAGGTATCAAGATGGTATCTGAAATAAGTGTGC           CACCATCACGACCTTTCCAACTAAGCTTATTAAATAACGGCTTGACGATGCTTCACACAAATGACTTT       TCTGGGCTTACCAATGCTATTTCAATACACCTTGGATTTAACAATATTGCAGATATTGAGATAGGTGC       ATTTAATGGCCTTGGCCTCCTGAAACAACTTCATATCAATCACAATTCTTTAGAAATTCTTAAAGAGG       TCCTCCAAACATCTTCCGATTTGTTCCTTTAACCCATCTAGATCTTCGTGGAAATCAATTACAAACAT       TGCCTTATGTTGGTTTTCTCGAACACATTGGCCGAATATTGGATCTTCAGTTGGAGGACAACAAATGG       GCCTGCAATTGTGACTTATTGCAGTTAAAAACTTGGTTGGAGAACATGCCTCCACAGTCTATAATTGG       TGATGTTGTCTGCAACAGCCCTCCATTTTTTAAAGGAAGTATACTCAGTAGACTAAAGAAGGAATCTA       TTTGCCCTACTCCACCAGTGTATGAAGAACATGAGGATCCTTCAGGATCATTACATCTGGCAGCAACA       TCTTCAATAAATGATAGTCGCATGTCAACTAAGACCACGTCCATTCTAAAACTACCCACCAAAGCACC       AGGTTTGATACCTTATATTACAAAGCCATCCACTCAACTTCCAGGACCTTACTGCCCTATTCCTTGTA       ACTGCAAAGTCCTATCCCCATCAGGACTTCTAATACATTGTCAGGAGCGCAACATTGAAAGCTTATCA       GATCTGAGACCTCCTCCGCAAAATCCTAGAAAGCTCATTCTAGCGGGAAATATTATTCACAGTTTAAT       GAAGTCTGATCTAGTGGAATATTTCACTTTGGAAATGCTTCACTTGGGAAACAATCGTATTGAAGTTC       TTGAAGAAGGATCGTTTATGAACCTAACGAGATTACAAAAACTCTATCTAAATGGTAACCACCTGACC       AAATTAAGTAAAGGCATGTTCCTTGGTCTCCATAATCTTGAATACTTATATCTTGAATACAATGCCAT       TAAGGAAATACTGCCAGGAACCTTTAATCCAATGCCTAAACTTAAAGTCCTGTATTTAAATAACAACC       TCCTCCAAGTTTTACCACCACATATTTTTTCAGGGGTTCCTCTAACTAAGGTAAATCTTAAAACAAAC       CAGTTTACCCATCTACCTGTAAGTAATATTTTGGATGATCTTGATTTACTAACCCAGATTGACCTTGA       GGATAACCCCTGGGACTGCTCCTGTGACCTGGTTGGACTGCAGCAATGGATACAAAAGTTAAGCAAGA       ACACAGTGACAGATGACATCCTCTGCACTTCCCCCGGGCATCTCGACAAAAAGGAATTGAAAGCCCTA       AATAGTGAAATTCTCTGTCCAGGTTTAGTAAATAACCCATCCATGCCAACACAGACTAGTTACCTTAT       GGTCACCGTC GACGGC                                           NOV25l, CG55033-07                       Protein Sequence   SEQ ID NO: 588   542 aa   MW at 60659.6kD                     MLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGL           GLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNI       FRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVC       NSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIP       YITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDL       VEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEIL       PGTFNPMPKLKTLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPW       DCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVT                                     NOV25m, CG55033-08   SEQ ID NO: 589   643 bp           DNA Sequence   ORF Start: ATG at 9   ORF Stop: at 1635                       GCGGCCGC   ATG CTAATAAATTGTGAAGCAAAAGGTATCAAGATGGTATCTGAAATAAGTGTGCCACCA           TCACGACCTTTCCAACTAAGCTTATTAAATAACGGCTTGACGATGCTTCACACAAATGACTTTTCTGG       GCTTACCAATGCTATTTCAATACACCTTGGATTTAACAATATTGCAGATATTGAGATAGGTGCATTTA       ATGGCCTTGGCCTCCTGAAACAACTTCATATCAATCACAATTCTTTAGAAATTCTTAAAGAGGATACT       TTCCATGGACTGGAAAACCTGGAATTCCTGCAAGCAGATAACAATTTTATCACAGTGATTGAACCAAG       TGCCTTTAGCAAGCTCAACAGACTCAAAGTGTTAATTTTAAATGACAATGCTATTGAGAGTCTTCCTC       CAAACATCTTCCGATTTGTTCCTTTAACCCATCTAGATCTTCGTGGAAATCAATTACAAACATTGCCT       TATGTTGGTTTTCTCGAACACATTGGCCGAATATTGGATCTTCAGTTGGAGGACAACAAATGGGCCTG       CAATTGTGACTTATTGCAGTTAAAAACTTGGTTGGAGAACATGCCTCCACAGTCTATAATTGGTGATG       TTGTCTGCAACAGCCCTCCATTTTTTAAAGGAAGTATACTCAGTAGACTAAAGAAGGAATCTATTTGC       CCTACTCCACCAGTGTATGAAGAACATGAGGATCCTTCAGGATCATTACATCTGGCAGCAACATCTTC       AATAAATGATAGTCGCATGTCAACTAAGACCACGTCCATTCTAAAACTACCCACCAAAGCACCAGGTT       TGATACCTTATATTACAAAGCCATCCACTCAACTTCCAGGACCTTACTGCCCTATTCCTTGTAACTGC       AAAGTCCTATCCCCATCAGGACTTCTAATACATTGTCAGGAGCGCAACATTGAAAGCTTATCAGATCT       GAGACCTCCTCCGCAAAATCCTAGAAAGCTCATTCTAGCGGGAAATATTATTCACAGTTTAATGAAGT       CTGATCTAGTGGAATATTTCACTTTGGAAATGCTTCACTTGGGAAACAATCGTATTGAAGTTCTTGAA       GAAGGATCGTTTATGAACCTAACGAGATTACAAAAACTCTATCTAAATGGTAACCACCTGACCAAATT       AAGTAAAGGCATGTTCCTTGGTCTCCATAATCTTGAATACTTATATCTTGAATACAATGCCATTAAGG       CAAGTTTTACCACCACATATTTTTTCAGGGGTTCCTCTAACTAAGGTAAATCTTAAAACAAACCAGTT       TACCCATCTACCTGTAAGTAATATTTTGGATGATCTTGATTTACTAACCCAGATTGACCTTGAGGATA       ACCCCTGGGACTGCTCCTGTGACCTGGTTGGACTGCAGCAATGGATACAAAAGTTAAGCAAGAACACA       GTGACAGATGACATCCTCTGCACTTCCCCCGGGCATCTCGACAAAAGGAAATTGAAAGCCCTAAATAG       TGAAATTCTCTGTCCAGGTTTAGTAAATAACCCATCCATGCCAACACAGACTAGTTACCTTATGGTCA       CCCTC GAGGGC                                           NOV25m, CG55033-08                       Protein Sequence   SEQ ID NO: 590   542 aa   MW at 60659.6kD                     MLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGL           GLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNI       FRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVC       NSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIP       YITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDL       VEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEIL       PGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPW       DCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSETLCPGLVNNPSMPTQTSYLMVT                                     NOV25n, CG55033-09   SEQ ID NO: 591   2838 bp           DNA Sequence   ORF Start: ATG at 184   ORF Stop: TAG at 2707                       AACTTTATGAAGCTATGGGACTTGACAAAAAGTGATATTTGAGAAGAAAGTACGCAGTGGTTGGTGTT               TTCTTTTTTTTAATAAAGGAATTGAATTACTTTGAACACCTCTTCCAGCTGTGCATTACAGATAACGT           CAGGAAGAGTCTCTGCTTTACAGAATCGGATTTCATCACATGACAAC   ATG AAGCTGTGGATTCATCTC       TTTTATTCATCTCTCCTTGCCTGTATATCTTTACACTCCCAAACTCCAGTGCTCTCATCCAGAGGCTC       TCAAGATGGTATCTGAAATAAGTGTGCCACCATCACGACCTTTCCAACTAAGCTTATTAAATAACGGC       TTGACGATGCTTCACACAAATGACTTTTCTGGGCTTACCAATGCTATTTCAATACACCTTGGATTTAA       CAATATTGCAGATATTGAGATAGGTGCATTTAATGGCCTTGGCCTCCTGAAACAACTTCATATCAATC       ACAATTCTTTAGAAATTCTTAAAGAGGATACTTTCCATGGACTGGAAAACCTGGAATTCCTGCAAGCA       GATAACAATTTTATCACAGTGATTGAACCAAGTGCCTTTAGCAAGCTCAACAGACTCAAAGTGTTAAT       TTTAAATGACAATGCTATTGAGAGTCTTCCTCCAAACATCTTCCGATTTGTTCCTTTAACCCATCTAG       ATCTTCGTGGAAATCAATTACAAACATTGCCTTATGTTGGTTTTCTCGAACACATTGGCCGAATATTG       GATCTTCAGTTGGAGGACAACAAATGGGCCTGCAATTGTGACTTATTGCAGTTAAAAACTTGGTTGGA       GAACATGCCTCCACAGTCTATAATTGGTGATGTTGTCTGCAACAGCCCTCCATTTTTTAAAGGAAGTA       TACTCAGTAGACTAAAGAAGGAATCTATTTGCCCTACTCCACCAGTGTATGAAGAACATGAGGATCCT       TCAGGATCATTACATCTGGCAGCAACATCTTCAATAAATGATAGTCGCATGTCAACTAAGACCACGTC       CATTCTAAAACTACCCACCAAAGCACCAGGTTTGATACCTTATATTACAAAGCCATCCACTCAACTTC       CAGGACCTTACTGCCCTATTCCTTGTAACTGCAAAGTCCTATCCCCATCAGGACTTCTAATACATTGT       CAGGAGCGCAACATTGAAAGCTTATCAGATCTGAGACCTCCTCCGCAAAATCCTAGAAAGCTCATTCT       AGCGGGAAATATTATTCACAGTTTAATGAAGTCTGATCTAGTGGAATATTTCACTTTGGAAATGCTTC       ACTTGGGAAACAATCGTATTGAAGTTCTTGAAGAAGGATCGTTTATGAACCTAACGAGATTACAAAAA       CTCTATCTAAATGGTAACCACCTGACCAAATTAAGTAAAGGCATGTTCCTTGGTCTCCATAATCTTGA       ATACTTATATCTTGAATACAATGCCATTAAGGAAATACTGCCAGGAACCTTTAATCCAATGCCTAAAC       TTAAAGTCCTGTATTTAAATAACAACCTCCTCCAAGTTTTACCACCACATATTTTTTCAGGGGTTCCT       CTAACTAAGGTAAATCTTAAAACAAACCAGTTTACCCATCTACCTGTAAGTAATATTTTGGATGATCT       TGATTTACTAACCCAGATTGACCTTGAGGATAACCCCTGGGACTGCTCCTGTGACCTGGTTGGACTGC       CTCGACAAAAAGGAATTGAAAGCCCTALATAGTGAAATTCTCTGTCCAGGTTTAGTAAATAACCCATC       CATGCCAACACAGACTAGTTACCTTATGGTCACCACTCCTGCAACAACAACAAATACGGCTGATACTA       TTTTACGATCTCTTACGGACGCTGTGCCACTGTCTGTTCTAATATTGGGACTTCTGATTATGTTCATC       ACTATTGTTTTCTGTGCTGCAGGGATAGTGGTTCTTGTTCTTCACCGCAGGAGAAGATACAAAAAGAA       ACAAGTAGATGAGCAAATGAGAGACAACAGTCCTGTGCATCTTCAGTACAGCATGTATGGCCATAAAA       CCACTCATCACACTACTGAAAGACCCTCTGCCTCACTCTATGAACAGCACATGGTGAGCCCCATGGTT       CATGTCTATAGAAGTCCATCCTTTGGTCCAAAGCATCTGGAAGAGGAAGAAGAGAGGAATGAGAAAGA       AGGAAGTGATGCAAAACATCTCCAAAGAAGTCTTTTGGAACAGGAAAATCATTCACCACTCACAGGGT       TACAGAAACATTTTAGAAAAAGAAAGGGAACTTCAGCAACTGGGAATCACAGAATACCTAAGGAAAAA       CATTGCTCAGCTCCAGCCTGATATGGAGGCACATTATCCTGGAGCCCACGAAGAGCTGAAGTTAATGG       AAACATTAATGTACTCACGTCCAAGGAAGGTATTAGTGGAACAGACAAAAAATGAGTATTTTGAACTT       AAAGCTAATTTACATGCTGAACCTGACTATTTAGAAGTCCTGGAGCAGCAAACA TAG   ATGGAGAGTAT           GAGGGCTTTCGCAGAAATGCTGTGATTCTGTTTTAAGTCCATACCTTGTAAATTAGTGCCTTACGTGA           GTGTGTCATCCATCAGAACCTAAGCACAGCAGTAAACTATGGAGAAAAAA                                           NOV25n, CG55033-09                       Protein Sequence   SEQ ID NO: 592   841 aa   MW at 95108.5kD                     MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQ           LSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFNGLE       NLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFL       EHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPV       YEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSP       SGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFM       NLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPP       HIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDI       LCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLIL       GLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSASLYEQ       FQDASSLYRNILEKERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQT       KNEYFELKANLHAEPDYLEVLEQQT                                     NOV25o, CG55033-10   SEQ ID NO: 593   2531 bp           DNA Sequence   ORF Start: at 2   ORF Stop: TAA at 2513                       G GATTCTCTCTTTTATTCATCTCTCCTTGCCTGTATATCTTTACACTCCCAAACTCCAGTGCTCTCAT           CCAGAGGCTCTTGTGATTCTCTTTGCAATTGTGAGGAAAAAGATGGCACAATGCTAATAAATTGTGAA       GCAAAAGGTATCAAGATGGTATCTGAAATAAGTGTGCTACCATCACGACCTTTCCAACTAAGCTTATT       AAATAACGGCTTGACGATGCTTCACACAAATGACTTTTCTGGGCTTACCAATGCTATTTCAATACACC       TTGGATTTAACAATATTGCAGATATTGAGATAGGTGCATTTAATGGCCTTGGCCTCCTGAAACAACTT       CATATCAATCACAATTCTTTAGAAATTCTTAAAGAGGATACTTTCCATGGACTGGAAAACCTGGAATT       CCTGCAAGCAGATAACAATTTTATCACAGTGATTGAACCAAGTGCCTTTAGCAAGCTCAACAGACTCA       AAGTGTTAATTTTAAATGACAATGCTATTGAGAGTCTTCCTCCAAACATCTTCCGATTTGTTCCTTTA       ACCCATCTAGATCTTCGTGGAAATCAATTACAAACATTGCCTTATGTTGGTTTTCTCGAACACATTGG       CCGAATATTGGATCTTCAGTTGGAGGACAACAAATGGGCCTGCAATTGTGACTTATTGCAGTTAAAAA       CTTGGTTGGAGAACATGCCTCCACAGTCTATAATTGGTGATGTTGTCTGCAACAGCCCTCCATTTTTT       AAAGGAAGTATACTCAGTAGACTAAAGAAGGAATCTATTTGCCCTACTCCACCAGTGTATGAAGAACA       TGAGGATCCTTCAGGATCATTACATCTGGCAGCAACATCTTCAATAAATGATAGTCGCATGTCAACTA       AGACCACGTCCATTCTAAAACTACCCACCAAAGCACCAGGTTTGATACCTTATATTACAAAGCCATCC       ACTCAACTTCCAGGACCTTACTGCCCTATTCCTTGTAACTGCAAAGTCCTATCCCCATCAGGACTTCT       AATACATTGTCAGGAGCGCAACAATTGAAAGCTTATCAGATCTGAGACCTCCTCCGCAAATCCTAGAA       AGCTCATTCTAGCGGGAAATATTATTCACAGTTTAATGAAGTCTGATCTAGTGGAATATTTCACTTTG       GAATGCTTCACTTGGGAACAATCGTATTGAAGTTCTTGAAGAAGGATCGTTTATGAACCTAAAACGAG       ATTACAAAAACTCTATCTAAATGGTAACCACCTGACCAAATTAAGTAAAGGCATGTTCCTTGGTCTCC       ATAATCTTGAATACTTATATCTTGAATACAATGCCATTAAGGAAATACTGCCAGGAACCTTTAATCCA       ATGCCTAAACTTAAAGTCCTGTATTTAAATAACAACCTCCTCCAAGTTTTACCACCACATATTTTTTC       AGGGGTTCCTCTAACTAAGGTAAATCTTAAAACAAACCAGTTTACCCATCTACCTGTAAGTAATATTT       TGGATGATCTTGATTTGCTAACCCAGATTGACCTTGAGGATAACCCCTGGGACTGCTCCTGTGACCTG       GTTGGACTGCAGCAATGGATACAAAAGTTAAGCAAGAACACAGTGACAGATGACATCCTCTGCACTTC       CCCCGGGCATCTCGACAAAAAGGAATTGAAAGCCCTAAATAGTGAAATTCTCTGTCCAGGTTTAGTAA       ATAACCCATCCATGCCAACACAGACTAGTTACCTTATGGTCACCACTCCTGCAACAACAACAAATACG       GCTGATACTATTTTACGATCTCTTACGGACGCTGTGCCACTGTCTGTTCTAATATTGGGACTTCTGAT       TATGTTCATCACTATTGTTTTCTGTGCTGCAGGGATAGTGGTTCTTGTTCTTCACCGCAGGAGAAGAT       ACAAAAAGAAACAAGTAGATGAGCAAATGAGAGACAACAGTCCTGTGCATCTTCAGTACAGCATGTAT       GGCCATAAAACCACTCATCACACTACTGAAAGACCCTCTGCCTCACTCTATGAACAGCACATGGTGAG       CCCCATGGTTCATGTCTATAGAAGTCCATCCTTTGGTCCAAAGCATCTGGAAGAGGAAGAAGAGAGGA       ATGAGAAAGAAGGAAGTGATGCAAAACATCTCCAAAGAAGTCTTTTGGAACAGGAAAATCATTCACCA       CTCACAGGGTCAAATATGAAATACAAAACCACGAACCAATCAACAGAATTTTTATCCTTCCAAGATGC       CAGCTCATTGTACAGAAACATTTTAGAAAAAGAAAGGGAACTTCAGCAACTGGGAATCACAGAATACC       TAAGGAAAAAACATTGCTCAGCTCCAGCCTGATATGGAGGCACATTATCCTGGAGCCACGAAGAGCTG       AAGTTAATGGAACATTAATGTACTCACGTCCAAGGAAGGTATTAGTGGAACAGACAAAAAAATGAGTA       TTTTGAACTTAAAGCTAATTTACATGCTGAACCTGACTATTTAGAAGTCCTGGAGCAGCAAACA TAA   G           GGCGAATTCTGCTGT                                           NOV25o, CG55033-10                       Protein Sequence   SEQ ID NO: 594   837 aa   MW at 94517.6kD                     DSLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVLPSRPFQLSLL           NNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEF       LQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIG       RILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEH       EDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLL       IHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTR       LQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFS       GVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTS       PGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLILGLLI       MFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVS       PMVHVYRSPSFFGPKHLEEEEERNEKEGSDAKHLQRSLLEQENHSPLTGSNMYKTTNQSTEFLSFQDA       SSLYRNILEKERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEY       FELKANLHAEPDYLEVLEQQT                                     NOV25p, CG55033-11   SEQ ID NO: 595   1758 bp           DNA Sequence   ORF Start: at 10   ORF Stop: at 1750                       CGCGGATCC CAAACTCCAGTGCTCTCATCCAGAGGCTCTTGTGATTCTCTTTGCAATTGTGAGGAAAA           AGATGGCACAATGCTAATAAATTGTGAAGCAAAAGGTATCAAGATGGTATCTGAAATAAGTGTGCCAC       CATCACGACCTTTCCAACTAAGCTTATTAAATAACGGCTTGACGATGCTTCACACAAATGACTTTTCT       GGGTTACCAATGCTATTTCAATACACCTTGGATTTAACAATATTGCAGATATTGAGATAGGTAGCATT       TAATGGCCTTGGCCTCCTGAAACAACTTCATATCAATCACAATTCTTTAGAAATTCTTAAAGAGGATA       CTTTCCATGGACTGGAAAACCTGGAATTCCTGCAAGCAGATAACAATTTTATCACAGTGATTGAACCA       AGTGCCTTTAGCAAGCTCAACAGACTCAAAGTGTTAATTTTAAATGACAATGCTATTGAGAGTCTTCC       TCCAAACATCTTCCGATTTGTTCCTTTAACCCATCTAGATCTTCGTGGAAATCAATTACAAACATTGC       CTTATGTTGGTTTTCTCGAACACATTGGCCGAATATTGGATCTTCAGTTGGAGGACAACAAATGGGCC       TGCAATTGTGACTTATTGCAGTTAAAAACTTGGTTGGAGAACATGCCTCCACAGTCTATAATTGGTGA       TGTTGTCTGCAACAGCCCTCCATTTTTTAAAGGAAGTATACTCAGTAGACTAAGAAGGAATCTAATTT       GCCCTACTCCACCAGTGTATGAAGAACATGAGGATCCTTCAGGATCATTACATCTGGCAGCAACATCT       TCAATAAATGATAGTCGCATGTCAACTAAGACCACGTCCATTCTAAAACTACCCACCAAAGCACCAGG       TTTGATACCTTATATTACAAAGCCATCCACTCAACTTCCAGGACCTTACTGCCCTATTCCTTGTAACT       GCAAAGTCCTATCCCCATCAGGACTTCTAATACATTGTCAGGAGCGCAACATTGAAAGCTTATCAGAT       CTGAGACCTCCTCCGCAAAATCCTAGAAAGCTCATTCTAGCGGGAAATATTATTCACAGTTTAATGAA       GTCTGAGCTAGTGGAATATTTCACTTTGGAAATGCTTCACTTGGGAAACAATCGTATTGAAGTTCTTG       AAGAAGGATCGTTTATGAACCTAACGAGATTACAAAAACTCTATCTAAATGGTAACCACCTGACCAAA       TTAAGTAAAGGCATGTTCCTTGGTCTCCATAATCTTGAATACTTATATCTTGAATACAATGCCATTAA       GGAATACTGCCAGGAACCTTTAATCCAATGCCTAAACTTAAAGTCCTGTATTTAAATAAACAACCTCC       TCCAAGTTTTACCACCACATATTTTTTCAGGGGTTCCTCTAACTAAGGTALATCTTAAAACAAACCAG       TTTACCCATCTACCTGTAAGTAATATTTTGGATGATCTTGATTTACTAACCCAGATTGACCTTGAGGA       TAACCCCTGGGACTGCTCCTGTGACCTGGTTGGACTGCAGCAATGGATACAAAAGTTAAGCAAGAACA       CAGTGACAGATGACATCCTCTGCACTTCCCCCGGGCATCTCGACAAAAAGGAATTGAAAGCCCTAAAT       AGTGAAATTCTCTGTCCAGGTTTAGTAAATAACCCATCCATGCCAACACAGACTAGTTACCTTATGGT       CACCACTCCTGCAACAACAACAAATACGGCTGATACTATTTTACGATCTCTC GAGGCG                                           NOV25p, CG55033-11                       Protein Sequence   SEQ ID NO: 596   580 aa   MW at 64615.9kD                     QTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLT           NAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAF       SKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNC       DLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSIN       DSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRP       PPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSK       GMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTH       LPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEI       LCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRS                                     NOV25q, CG55033-12   SEQ ID NO: 597   1762 bp           DNA Sequence   ORF Start: at 14   ORF Stop: at 1754                       CACCTCGCGAACC CAAACTCCAGTGCTCTCATCCAGAGGCTCTTGTGATTCTCTTTGCAATTGTGAGG           AAAAAGATGGCACAATGCTAATAAATTGTGAAGCAAAAGGTATCAAGATGGTATCTGAAATAAGTGTG       CCACCATCACGACCTTTCCAACTAAGCTTATTAAATAACGGCTTGACGATGCTTCACACAAATGACTT       CATTTAATGGCCTTGGCCTCCTGAAACAACTTCATATCAATCACAATTCTTTAGAAATTCTTAAAGAG       GATACTTTCCATGGACTGGAAAACCTGGAATTCCTGCAAGCAGATAACAATTTTATCACAGTGATTGA       ACCAAGTGCCTTTAGCAAGCTCAACAGACTCAAAGTGTTAATTTTAAATGACAATGCTATTGAGAGTC       TTCCTCCAAACATCTTCCGATTTGTTCCTTTAACCCATCTAGATCTTCGTGGAAATCAATTACAAACA       TTGCCTTATGTTGGTTTTCTCGAACACATTGGCCGAATATTGGATCTTCAGTTGGAGGACAACAAATG       GGCCTGCAATTGTGACTTATTGCAGTTAAAAACTTGGTTGGAGAACATGCCTCCACAGTCTATAATTG       GTGATGTTGTCTGCAACAGCCCTCCATTTTTTAAAGGAAGTATACTCAGTAGACTAAAGAAGGAATCT       ATTTGCCCTACTCCACCAGTGTATGAAGAACATGAGGATCCTTCAGGATCATTACATCTGGCAGCAAC       ATCTTCAATAAATGATAGTCGCATGTCAACTAAGACCACGTCCATTCTAAAACTACCCACCAAAGCAC       CAGGTTTGATACCTTATATTACAAAGCCATCCACTCAACTTCCAGGACCTTACTGCCCTATTCCTTGT       AACTGCAAAGTCCTATCCCCATCAGGACTTCTAATACATTGTCAGGAGCGCAACATTGAAAGCTTATC       AGATCTGAGACCTCCTCCGCAAAATCCTAGAAAGCTCATTCTAGCGGGAAATATTATTCACAGTTTAA       TGAAGTCTGATCTAGTGGAATATTTCACTTTGGAAATGCTTCACTTGGGAAACAATCGTATTGAAGTT       CAAATTAAGTAAAGGCATGTTCCTTGGTCTCCATAATCTTGAATACTTATATCTTGAATACAATGCCA       TTAAGGAAATACTGCCAGGAACCTTTAATCCAATGCCTAAACTTAAAGTCCTGTATTTAAATAACAAC       CTCCTCCAAGTTTTACCACCACATATTTTTTCAGGGGTTCCTCTAACTAAGGTAAATCTTAAAACAAA       CCAGTTTACCCATCTACCTGTAAGTAATATTTTGGATGATCTTGATTTACTAACCCAGATTGACCTTG       AGGATAACCCCTGGGACTGCTCCTGTGACCTGGTTGGACTGCAGCAATGGATACAAAAGTTAAGCAAG       AACACAGTGACAGATGACATCCTCTGCACTTCCCCCGGGCATCTCGACAAAAAGGAATTGAAAGCCCT       AAATAGTGAAATTCTCTGTCCAGGTTTAGTAAATAACCCATCCATGCCAACACAGACTAGTTACCTTA       TGGTCACCACTCCTGCAACAACAACAAATACGGCTGATACTATTTTACGATCTGTC GACGGC                                           NOV25q, CG55033-12                       Protein Sequence   SEQ ID NO: 598   580 aa   MW at 64615.9kD                     QTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLT           NAISIHLGFNNIADIEIGAFNGLGLLKQLHINhNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAF       SKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNC       DLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSIN       DSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRP       PPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSK       GMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTH       LPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEI       LCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRS                                     NOV25r, CG55033-13   SEQ ID NO: 599   2481 bp           DNA Sequence   ORF Start: at 10   ORF Stop: at 2473                       CGCGGATCC CAAACTCCAGTGCTCTCATCCAGAGGCTCTTGTGATTCTCTTTGCAATTGTGAGGAAAA           AGATGGCACAATGCTAATAAATTGTGAAGCAAAAGGTATCAAGATGGTATCTGAAATAAGTGTGCCAC       CATCACGACCTTTCCAACTAAGCTTATTAAATAACGGCTTGACGATGCTTCACACAAATGACTTTTCT       GGGCTTACCAATGCTATTTCAATACACCTTGGATTTAACAATATTGCAGATATTGAGATAGGTGCATT       TAATGGCCTTGGCCTCCTGAAACAACTTCATATCAATCACAATTCTTTAGAAATTCTTAAAGAGGATA       CTTTCCATGGACTGGAAAACCTGGAATTCCTGCAAGCAGATAACAATTTTATCACAGTGATTGAACCA       AGTGCCTTTAGCAAGCTCAACAGACTCAAAGTGTTAATTTTAAATGACAATGCTATTGAGAGTCTTCC       TCCAAACATCTTCCGATTTGTTCCTTTAACCCATCTAGATCTTCGTGGAAATCAATTACAAACATTGC       CTTATGTTGGTTTTCTCGAACACATTGGCCGAATATTGGATCTTCAGTTGGAGGACAACAAATGGGCC       TGCAATTGTGACTTATTGCAGTTAAAAACTTGGTTGGAGAACATGCCTCCACAGTCTATAATTGGTGA       TGTTGTCTGCAACAGCCCTCCATTTTTTAAAGGAAGTATACTCAGTAGACTAAAGAAGGAATCTATTT       GCCCTACTCCACCAGTGTATGAAGAACATGAGGATCCTTCAGGATCATTACATCTGGCAGCAACATCT       TCAATAAATGATAGTCGCATGTCAACTAAGACCACGTCCATTCTAAAACTACCCACCAAAGCACCAGG       TTTGATACCTTATAAATTACAGCCATCCACTCAACTTCCAGGACCTTACTGCCCTATTCCTTGTAACT       GCAAAGTCCTATCCCCATCAGGACTTCTAATACATTGTCAGGAGCGCAACATTGAAAGCTTATCAGAT       GCAAAGTCCTATCCCCATCAGGACTTCTAATACATTGTCAGGAGCGCAACATTGAAAGCTTATCAGAT       CTGAGACCTCCTCCGCAAAATCCTAGAAAGCTCATTCTAGCGGGAAATATTATTCACAGTTTAATGAA       GTCTGATCTAGTGGAATATTTCACTTTGGAAATGCTTCACTTGGGAAACAATCGTATTGAAGTTCTTG       AAGAAGGATCGTTTATGAACCTAACGAGATTACAAAAACTCTATCTAAATGGTAACCACCTGACCAAA       TTAAGTAAAGGCATGTTCCTTGGTCTCCATAATCTTGAATACTTATATCTTGAATACAATGCCATTAA       GGAAATACTGCCAGGAACCTTTAATCCAATGCCTAAACTTAAAGTCCTGTATTTAAATAACAACCTCC       TCCAAGTTTTACCACCACATATTTTTTCAGGGGTTCCTCTAACTAAGGTAAATCTTAAAACAAACCAG       TTTACCCATCTACCTGTAAGTAATATTTTGGATGATCTTGATTTACTAACCCAGATTGACCTTGAGGA       TAACCCCTGGGACTGCTCCTGTGACCTGGTTGGACTGCAGCAATGGATACAAAAGTTAAGCAAGAACA       CAGTGACAGATGACATCCTCTGCACTTCCCCCGGGCATCTCGACAAAAAGGAATTGAAAGCCCTAAAT       AGTGAAATTCTCTGTCCAGGTTTAGTAAATAACCCATCCATGCCAACACAGACTAGTTACCTTATGGT       CACCACTCCTGCAACAACAACAAATACGGCTGATACTATTTTACGATCTCTTACGGACGCTGTGCCAC       TGTCTGTTCTAATATTGGGACTTCTGATTATGTTCATCACTATTGTTTTCTGTGCTGCAGGGATAGTG       GTTCTTGTTCTTCACCGCAGGAGAAGATACAAAAAGAAACAAGTAGATGAGCAAATGAGAGACAACAG       TCCTGTGCATCTTCAGTACAGCATGTATGGCCATAAAACCACTCATCACACTACTGAAAGACCCTCTG       CCTCACTCTATGAACAGCACATGGTGAGCCCCATGGTTCATGTCTATAGAAGTCCATCCTTTGGTCCA       TCTTTTGGAACAGGAAAATCATTCACCACTCACAGGGTCAAATATGAAATACAAAACCACGAACCAAT       CAACAGAATTTTTATCCTTCCAAGATGCCAGCTCATTGTACAGAAACATTTTAGAAAAAGAAAGGGAA       ACATTATCCTGGAGCCCACGAAGAGCTGAAGTTAATGGACATTAATGTACTCACGTCACAAGGAAAGG       TATTAGTGGAACAGACAAAAAATGAGTATTTTGAACTTAAAGCTAATTTACATGCTGAACCTGACTAT       TTAGAAGTCCTGGAGCAGCAAACACTC GAGGCG                                           NOV25r, CG55033-13                       Protein Sequence   SEQ ID NO: 600   821 aa   MW at 92763.6kD                     QTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLT           NAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAF       SKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNC       DLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSPLKKESICPTPPVYEEHEDPSGSLHLAATSSIN       DSRNSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRP       PPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSK       GMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTH       LPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEI       LCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLV       LHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSASLYEQHMVSPMVHVYRSPSFGPKHL       EEEEERNEKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERELQQ       LGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLEV       LEQQT                                     NOV25s, CG55033-14   SEQ ID NO: 601   2548 bp           DNA Sequence   ORF Start: ATG at 14   ORF Stop: TGA at 2537                       CACCGGTACCACC   ATG AAGCTGTGGATTCATCTCTTTTATTCATCTCTCCTTGCCTGTATATCTTTAC           ACTCCCAAACTCCAGTGCTCTCATCCAGAGGCTCTTGTGATTCTCTTTGCAATTGTGAGGAAAAAGAT       GGCACAATGCTAATAAATTGTGAAGCAAAAGGTATCAAGATGGTATCTGAAATAAGTGTGCCACCATC       ACGACCTTTCCAACTAAGCTTATTAAATAACGGCTTGACGATGCTTCACACAAATGACTTTTCTGGGC       TTACCAATGCTATTTCAATACACCTTGGATTTAACAATATTGCAGATATTGAGATAGGTGCATTTAAT       GGCCTTGGCCTCCTGAAACAACTTCATATCAATCACAATTCTTTAGAAATTCTTAAAGAGGATACTTT       CCATGGACTGGAAAACCTGGAATTCCTGCAAGCAGATAACAATTTTATCACAGTGATTGAACCAAGTG       CCTTTAGCAAGCTCAACAGACTCAAAGTGTTAATTTTAAATGACAATGCTATTGAGAGTCTTCCTCCA       AACATCTTCCGATTTGTTCCTTTAACCCATCTAGATCTTCGTGGAAATCAATTACAAACATTGCCTTA       TGTTGGTTTTCTCGAACACATTGGCCGAATATTGGATCTTCAGTTGGAGGACAACAAATGGGCCTGCA       ATTGTGACTTATTGCAGTTAAAAACTTGGTTGGAGAACATGCCTCCACAGTCTATAATTGGTGATGTT       GTCTGCAACAGCCCTCCATTTTTTAAAGGAAGTATACTCAGTAGACTAAAGAAGGAATCTATTTGCCC       TACTCCACCAGTGTATGAAGAACATGAGGATCCTTCAGGATCATTACATCTGGCAGCAACATCTTCAA       TAAATGATAGTCGCATGTCAACTAAGACCACGTCCATTCTAAAACTACCCACCAAAGCACCAGGTTTG       ATACCTTATATTACAAAGCCATCCACTCAACTTCCAGGACCTTACTGCCCTATTCCTTGTAACTGCAA       AGTCCTATCCCCATCAGGACTTCTAATACATTGTCAGGAGCGCAACATTGAAAGCTTATCAGATCTGA       GACCTCCTCCGCAAAATCCTAGAAAGCTCATTCTAGCGGGAAATATTATTCACAGTTTAATGAAGTCT       GATCTAGTGGAATATTTCACTTTGGAAATGCTTCACTTGGGAAACAATCGTATTGAAGTTCTTGAAGA       AGGATCGTTTATGAACCTAACGAGATTGCAAAAACTCTATCTAAATGGTAACCACCTGACCAAATTAA       GTAAAGGCATGTTCCTTGGTCTCCATAATCTTGAATACTTATATCTTGAATACAATGCCATTAAGGAA       ATACTGCCAGGAACCTTTAATCCAATGCCTAAACTTAAAGTCCTGTATTTAAATAACAACCTCCTCCA       AGTTTTACCACCACATATTTTTTCAGGGGTTCCTCTAACTAAGGTAAATCTTAAAACAAACCAGTTTA       CCCATCTACCTGTAAGTAATATTTTGGATGATCTTGATTTACTAACCCAGATTGACCTTGAGGATAAC       CCCTGGGACTGCTCCTGTGACCTGGTTGGACTGCAGCAATGGATACAAAAGTTAAGCAAGAACACAGT       GACAGATGACATCCTCTGCACTTCCCCCGGGCATCTCGACAAAAAGGAATTGAAAGCCCTAAATAGTG       AAATTCTCTGTCCAGGTTTAGTAAATAACCCATCCATGCCAACACAGACTAGTTACCTTATGGTCACC       ACTCCTGCAACAACAACAAATACGGCTGATACTATTTTACGATCTCTTACGGACGCTGTGCCACTGTC       TGTTCTAATATTGGGACTTCTGATTATGTTCATCACTATTGTTTTCTGTGCTGCAGGGATAGTGGTTC       TTGTTCTTCACCGCAGGAGAAGATACAAAAAGAAACAAGTAGATGAGCAAATGAGAGACAACAGTCCT       GTGCATCTTCAGTACAGCATGTATGGCCATAAAACCACTCATCACACTACTGAAAGACCCTCTGCCTC       ACTCTATGAACAGCACATGGTGAGCCCCATGGTTCATGTCTATAGAAGTCCATCCTTTGGTCCAAAGC       ATCTGGAAGAGGAAGAAGAGAGGAATGAGAAAGAAGGAAGTGATGCAAAACATCTCCAAAGAAGTCTT       TTGGAACAGGAAAATCATTCACCACTCACAGGGTCAAATATGAAATACAAAACCACGAACCAATCAAC       AGAATTTTTATCCTTCCAAGATGCCAGCTCATTGTACAGAAACATTTTAGAAAAAGAAAGGGAACTTC       AGCAACTGGGAAATCACAGAATACCTAAGGAAAAACATTGCTCAGCTCCAGCCTGATATGGAGAACAT       TATCCTGGAGCCCACGAAGAGCTGAAGTTAATGGAAACATTAATGTACTCACGTCCAAGGAAGGTATT       AGTGGAACAGACAAAAAATGAGTATTTTGAACTTAAAGCTAATTTACATGCTGAACCTGACTATTTAG       AAGTCCTGGAGCAGCAAACA TGA   CTCGAGGGC                                           NOV25s, CG55033-14                       Protein Sequence   SEQ ID NO: 602   1841 aa   MW at 95108.5kD                     MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQ           LSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLE       NLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFL       EHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTPPV       YEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKPSTQLPGPYCPIPCNCKVLSP       SGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFM       NLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYEYNAIKEILPGATFNPMPKLKVLYLNNNLLQVLPP       HIFSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDI       LCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLIL       GLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSASLYEQ       HMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQRSLLEQENHSPLTGSNMKYKTTNQSTEFLS       FQDASSLYRNILEKERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQT       KNEYFELKANLHAEPDYLEVLEQQT                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 25B.  
               TABLE 25B                       Comparison of the NOV25 protein sequences.                                        NOV25a ------------------------------------------------------------           NOV25b MKLWIHLFYSSLLACISLHSQTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKIMVSEIS       NOV25c ------------------------------------------------------------       NOV25d ------------------------------------------------------------       NOV25e ------------------------------------------------------------       NOV25f ----------------RGTKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILS       NOV25g ----------------RGTKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILS       NOV25h ------------------------------------------------------------       NOV25i ------------------------------------------------------------       NOV25j ------------------------------------------------------------       NOV25k ------------------------------------------------------------       NOV25l ------------------------------------------------------------       NOV25m ------------------------------------------------------------       NOV25n ------------------------------------------------------------       NOV25o ------------------------------------------------------------       NOV25p ------------------------------------------------------------       NOV25q ------------------------------------------------------------       NOV25r ------------------------------------------------------------       NOV25s ------------------------------------------------------------               NOV25a ----------------------------------------MKLWIHLFYSSLLACISLHS       NOV25b VPPSRPFQLSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHIN       NOV25c ------------------------------------------------------------       NOV25d ------------------------------------------------------------       NOV25e ------------------------------------------------------------       NOV25f RLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITK       NOV25g RLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITK       NOV25h RLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITK       NOV25i RLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITK       NOV25j RLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITK       NOV25k ----------------------------------------MKLWIHLFYSSLLACISLHS       NOV25l ------------------------------------------------------------       NOV25m ------------------------------------------------------------       NOV25n ----------------------------------------MKLWIHLFYSSLLACISLHS       NOV25o --------------------------------------------DSLFYSSLLACISLHS       NOV25p ------------------------------------------------------------       NOV25q ------------------------------------------------------------       NOV25r ------------------------------------------------------------       NOV25s ----------------------------------------MKLWIHLFYSSLLACISLHS               NOV25a QTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH       NOV25b HNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIF       NOV25c -----------------------MLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH       NOV25d ------------------------------------------------------------       NOV25e -------------------TSRTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH       NOV25f PSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLM       NOV25g PSTQLPGPYCPIPCNCKVLSPSGLLIHCQERNIESLSDLRPPPQNPRKLILAGNIIHSLM       NOV25h -------------------RGTTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH       NOV25i -----------------------MLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH       NOV25j -----------------------MLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH       NOV25k QTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH       NOV25l -----------------------MLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH       NOV25m -----------------------MLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH       NOV25n QTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMIH       NOV25o QTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVLPSRPFQLSLLNNGLTMLH       NOV25p QTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH       NOV25q QTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH       NOV25r QTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH       NOV25s QTPVLSSRGSCDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLH               NOV25a TNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEF       NOV25b RFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQS       NOV25c TNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEF       NOV25d ------------------------------------------------------------       NOV25e TNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEF       NOV25f KSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEY       NOV25g KSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEY       NOV25h TNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEF       NOV25i TNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEF       NOV25j TNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINNNSLEILKEDTFHGLENLEF       NOV25k TNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEF       NOV25l TNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEF       NOV25m TNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEF       NOV25n TNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEF       NOV25o TNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEF       NOV25p ThDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEF       NOV25q TNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINNNSLEILKEDTFHGLENLEF       NOV25r TNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEF       NOV25s TNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEF               NOV25a LQADNNFITVIEPSAFSKLNRLKVLILNDNATESLPPNIFRFVPLTHLDLRGNQLQTLPY       NOV25b IIGDVVCNSPPFFKGSILSRLKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKT       NOV25c LQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPY       NOV25d ------------------------------------------------------------       NOV25e LQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPY       NOV25f LYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPV       NOV25g LYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPV       NOV25h LQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPY       NOV25i LQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPY       NOV25j LQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPY       NOV25k LQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPY       NOV25l LQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPY       NOV25m LQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPY       NOV25n LQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPY       NOV25o LQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPY       NOV25p LQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPY       NOV25q LQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPY       NOV25r LQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPY       NOV25s LQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPY               NOV25a VGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSR       NOV25b TSILKLPTKAPQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKA       NOV25c VGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSR       NOV25d ---------------RGTPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKA       NOV25e VGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSR       NOV25f SNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKA       NOV25g SNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKA       NOV25h VGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSR       NOV25i VGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSR       NOV25j VGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSR       NOV25k VGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSR       NOV25l VGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSR       NOV25m VGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSR       NOV25n VGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSR       NOV25o VGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSR       NOV25p VGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSR       NOV25q VGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSR       NOV25r VGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSR       NOV25s VGFLEHIGRILDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSR               NOV25a LKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP       NOV25b LNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLILGLLIMFI       NOV25c LKKESICPTPPVYEEHEDPSGSLHIAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP       NOV25d LNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLILGLLIMFI       NOV25e LKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP       NOV25f LNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLILGLLIMFI       NOV25g LNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLILGLLIMFI       NOV25h LKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP       NOV25i LKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP       NOV25j LKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRISTKTTSILKLPTKAPGLIPYITKP       NOV25k LKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP       NOV25l LKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP       NOV25m LKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP       NOV25n LKKESICPTPPVYEEHEDPSGSLHTAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP       NOV25o LKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP       NOV25p LKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP       NOV25q LKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP       NOV25r LKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP       NOV25s LKKESICPTPPVYEEHEDPSGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP               NOV25a STQLPGPYCPIPCNCKVLSPSGLLIHCQERN---------IESLSDLRPPPQNPRKLILA       NOV25b TIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSASLYE       NOV25c STQLPGPYCPIPCNCKVLSPSGLLIHCQERN---------IESLSDLRPPPQNPRKLILA       NOV25d TIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSASLYE       NOV25e STQLPGPYCPIPCNCKVLSPSGLLIHCQERN---------IESLSDLRPPPQNPRKLILA       NOV25f TIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSASLYE       NOV25g TIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTERPSASLYE       NOV25h STQLPGPYCPIPCNCKVLSPSGLLIHCQERN---------IESLSDLRPPPQNPRKLILA       NOV25i STQLPGPYCPIPCNCKVLSPSGLLIHCQEPN---------IESLSDLRPPPQNPRKLILA       NOV25j STQLPGPYCPIPCNCKVLSPSGLLIHCQERN---------IESLSDLRPPPQNPRKLILA       NOV25k STQLPGPYCPIPCNCKVLSPSGLLIHCQERN---------IESLSDLRPPPQNPRKLILA       NOV25l STQLPGPYCPIPCNCKVLSPSGLLIHCQERN---------IESLSDLRPPPQNPRKLILA       NOV25m STQLPGPYCPIPCNCKVLSPSGLLIHCQERN---------IESLSDLRPPPQNPRKLILA       NOV25n STQLPGPYCPIPCNCKVLSPSGLLIHCQERN---------IESLSDLRPPPQNPRXLILA       NOV25o STQLPGPYCPIPCNCKVLSPSGLLIHCQERN---------IESLSDLRPPPQNPRKLILA       NOV25p STQLPGPYCPIPCNCKVLSPSGLLIHCQERN---------IESLSDLRPPPQNPRKLILA       NOV25q STQLPGPYCPIPCNCKVLSPSGLLIHCQERN---------IESLSDLRPPPQNPRKLILA       NOV25r STQLPGPYCPIPCNCKVLSPSGLLIHCQERN---------IESLSDLRPPPQNPRKLILA       NOV25s STQLPGPYCPIPCNCKVLSPSGLLIHCQERN---------IESLSDLRPPPQNPRKLILA               NOV25a GNIIHSLMK---------------------------------------------------       NOV25b QHMVSPMVHVYR------------------------------------------------       NOV25c GNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFNNLTRLQKLYLNGNHLTKLSKGMF       NOV25d QHMVSPMVHVYR------------------------------------------------       NOV25e GNIIHSLMKS--------------------------------------------------       NOV25f QHMVSPMVHVYR------------------------------------------------       NOV25g QHMVSPMVHVYR------------------------------------------------       NOV25h GNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFTNLTRLQKLYLNGNHLTKLSKGMF       NOV25i GNIIHSLNKS--------------------------------------------------       NOV25j GNIIHSLMKS--------------------------------------------------       NOV25k GNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFTNLTRLQKLYLNGNHLTKLSKGMF       NOV25l GNIIHSLMKS--------------------------------------------------       NOV25m GNIIHSLMKS--------------------------------------------------       NOV25n GNIIHSLMKS--------------------------------------------------       NOV25o GNIIHSLMKS--------------------------------------------------       NOV25p GNIIHSLMKS--------------------------------------------------       NOV25q GNIIHSLMKS--------------------------------------------------       NOV25r GNIIHSLMKS--------------------------------------------------       NOV25s GNIIHSLMKS--------------------------------------------------               NOV25a ------------------------------------------------------------       NOV25b ------------------------------------------------------------       NOV25c LGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKT       NOV25d ------------------------------------------------------------       NOV25e ------------------------------------------------------------       NOV25f ------------------------------------------------------------       NOV25g ------------------------------------------------------------       NOV25h LGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKT       NOV25i ------------------------------------------------------------       NOV25j ------------------------------------------------------------       NOV25k LGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKT       NOV25l ------------------------------------------------------------       NOV25m ------------------------------------------------------------       NOV25n ------------------------------------------------------------       NOV25o ------------------------------------------------------------       NOV25p ------------------------------------------------------------       NOV25q ------------------------------------------------------------       NOV25r ------------------------------------------------------------       NOV25s ------------------------------------------------------------               NOV25a ------------------------------------------------------------       NOV25b ------------------------------------------------------------       NOV25c NQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGH       NOV25d ------------------------------------------------------------       NOV25e ------------------------------------------------------------       NOV25f ------------------------------------------------------------       NOV25g ------------------------------------------------------------       NOV25h NQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGH       NOV25i ------------------------------------------------------------       NOV25j ------------------------------------------------------------       NOV25k NQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGH       NOV25l ------------------------------------------------------------       NOV25m ------------------------------------------------------------       NOV25n ------------------------------------------------------------       NOV25o ------------------------------------------------------------       NOV25p ------------------------------------------------------------       NOV25q ------------------------------------------------------------       NOV25r ------------------------------------------------------------       NOV25s ------------------------------------------------------------               NOV25a ------------------------------------------------------------       NOV25b ------------------------------------------------------------       NOV25c LDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLI       NOV25d ------------------------------------------------------------       NOV25e ------------------------------------------------------------       NOV25f ------------------------------------------------------------       NOV25g ------------------------------------------------------------       NOV25h LDKKELKALNSEILCPGLVNNPSMPTQTSYLNVTTPATTTNTADTILRSLTDAVPLSVLI       NOV25i ------------------------------------------------------------       NOV25j ------------------------------------------------------------       NOV25k LDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVLI       NOV25l ------------------------------------------------------------       NOV25m ------------------------------------------------------------       NOV25n ------------------------------------------------------------       NOV25o ------------------------------------------------------------       NOV25p ------------------------------------------------------------       NOV25q ------------------------------------------------------------       NOV25r ------------------------------------------------------------       NOV25s ------------------------------------------------------------               NOV25a ------------------------------------------------------------       NOV25b ------------------------------------------------------------       NOV25c LGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTE       NOV25d ------------------------------------------------------------       NOV25e ------------------------------------------------------------       NOV25f ------------------------------------------------------------       NOV25g ------------------------------------------------------------       NOV25h LGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTE       NOV25i ------------------------------------------------------------       NOV25j ------------------------------------------------------------       NOV25k LGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTTE       NOV25l ------------------------------------------------------------       NOV25m ------------------------------------------------------------       NOV25n ------------------------------------------------------------       NOV25o ------------------------------------------------------------       NOV25p ------------------------------------------------------------       NOV25q ------------------------------------------------------------       NOV25r ------------------------------------------------------------       NOV25s ------------------------------------------------------------               NOV25a --------------------SPSFGPKHLEEEEE---RN----EKEGSDAKHLQRSLLEQ       NOV25b --------------------SPSFGPKHLEEEEE---RN----EKEGSDAKHLQRSLLEQ       NOV25c RPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEE---RN----EKEGSDAKHLQRSLLEQ       NOV25d --------------------SPSFGPKHLEEEEE---RN----EKEGSDAKHLQRSLLEQ       NOV25e -----------DLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGM       NOV25f --------------------SPSFGPKHLEEEEE---RN----EKEGSDAKHLQRSLLEQ       NOV25g --------------------SPSFGPKHLEEEEE---RN----EKEGSDAKHLQRSLLEQ       NOV25h RPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEE---RN----EKEGSDAKHLQRSLLEQ       NOV25i -----------DLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGM       NOV25j -----------DLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGM       NOV25k RPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEE---RN----EKEGSDAKHLQRSLLEQ       NOV25l -----------DLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGM       NOV25m -----------DLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGM       NOV25n -----------DLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGM       NOV25o -----------DLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGM       NOV25p -----------DLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGM       NOV25q -----------DLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGM       NOV25r -----------DLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGM       NOV25s -----------DLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGM               NOV25a EN----------------------HSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEK       NOV25b EN----------------------HSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEK       NOV25c EN----------------------HSPLTGSNNKYKTTNQSTEFLSFQDASSLYRNILEK       NOV25d EN----------------------HSPLTGSNMKYKTTNQSTEFLSFQDASSLYENILEK       NOV25e FLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLK       NOV25f EN----------------------HSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEK       NOV25g EN----------------------HSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEK       NOV25h EN----------------------HSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEK       NOV25i FLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLK       NOV25j FLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLK       NOV25k EN----------------------HSPLTGSNMKYKTTNQSTEFLSFQDASSLYRNILEK       NOV25l FLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNMC       NOV25m FLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLK       NOV25n FLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLK       NOV25o FLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLK       NOV25p FLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLK       NOV25q FLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLK       NOV25r FLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSOVPLTKVNLK       NOV25s FLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLK               NOV25a ERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPR-------------       NOV25b ERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPR-------------       NOV25c ERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPR-------------       NOV25d ERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPR-------------       NOV25e TNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPG       NOV25f ERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPR-------------       NOV25g ERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPR-------------       NOV25h ERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPR-------------       NOV25i TNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPG       NOV25j TNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPG       NOV25k ERELQQLGITEYLRKNIAQLQPDMEAHYPGAHEELKLMETLMYSRPR-------------       NOV25l TNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPG       NOV25m TNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPG       NOV25n TNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPG       NOV25o TNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPG       NOV25p TNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPG       NOV25q TNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPG       NOV25r TNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPG       NOV25s TNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPG               NOV25a -------KVLVEQTKNEYFELKANLHAEPDYLEVLEQQT---------------------       NOV25b -------KVLVEQTKNEYFELKANLHAEPDYLEVLEQQT---------------------       NOV25c -------KVLVEQTKNEYFELKANLHAEPDYLEVLEQQT---------------------       NOV25d -------KVLVEQTKNEYFELKANLHAEPDYLEVLEQQTLEA------------------       NOV25e HLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTVDG----------------------       NOV25f -------KVLVEQTKNEYFELKANLHAEPDYLEVLEQQTLEA------------------       NOV25g -------KVLVEQTKNEYFELKANLHAEPDYLEVLEQQTLEA------------------       NOV25h -------KVLVEQTKNEYFELKANLHAEPDYLEVLEQQTLEAKGEFQH------------       NOV25i HLDKKELKALNSEILCPGLVNNPSMPTQTSYLMBT-------------------------       NOV25j HLDKKELKALNSETLCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILR-----------       NOV25k -------KVLVEQTKNEYFELKANLHAEPDYLEVLEQQT---------------------       NOV25l HLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVT-------------------------       NOV25m HLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVT-------------------------       NOV25n HLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVL       NOV25o HLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVL       NOV25p HLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRS----------       NOV25q HLDKKELKALNSETLCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRS----------       NOV25r HLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVL       NOV25s HLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAVPLSVL               NOV25a ------------------------------------------------------------       NOV25b ------------------------------------------------------------       NOV25c ------------------------------------------------------------       NOV25d ------------------------------------------------------------       NOV25e ------------------------------------------------------------       NOV25f ------------------------------------------------------------       NOV25g ------------------------------------------------------------       NOV25h ------------------------------------------------------------       NOV25i ------------------------------------------------------------       NOV25j ------------------------------------------------------------       NOV25k ------------------------------------------------------------       NOV25l ------------------------------------------------------------       NOV25m ------------------------------------------------------------       NOV25n ILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTT       NOV25o ILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTT       NOV25p ------------------------------------------------------------       NOV25q ------------------------------------------------------------       NOV25r ILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTT       NOV25s ILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVDEQMRDNSPVHLQYSMYGHKTTHHTT               NOV25a ------------------------------------------------------------       NOV25b ------------------------------------------------------------       NOV25c ------------------------------------------------------------       NOV25d ------------------------------------------------------------       NOV25e ------------------------------------------------------------       NOV25f ------------------------------------------------------------       NOV25g ------------------------------------------------------------       NOV25h ------------------------------------------------------------       NOV25i ------------------------------------------------------------       NOV25j ------------------------------------------------------------       NOV25k ------------------------------------------------------------       NOV25l ------------------------------------------------------------       NOV25m ------------------------------------------------------------       NOV25n ERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQRSLLEQENHSPL       NOV25o ERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQRSLLEQENHSPL       NOV25p ------------------------------------------------------------       NOV25q ------------------------------------------------------------       NOV25r ERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQRSLLEQENHSPL       NOV25s ERPSASLYEQHMVSPMVHVYRSPSFGPKHLEEEEERNEKEGSDAKHLQRSLLEQENHSPL               NOV25a ------------------------------------------------------------       NOV25b ------------------------------------------------------------       NOV25c ------------------------------------------------------------       NOV25d ------------------------------------------------------------       NOV25e ------------------------------------------------------------       NOV25f ------------------------------------------------------------       NOV25g ------------------------------------------------------------       NOV25h ------------------------------------------------------------       NOV25i ------------------------------------------------------------       NOV25j ------------------------------------------------------------       NOV25k ------------------------------------------------------------       NOV25l ------------------------------------------------------------       NOV25m ------------------------------------------------------------       NOV25n TGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERELQQLGITEYLRKNIAQLQPDMEAHY       NOV25o TGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERELQQLGITEYLRKNIAQLQPDMEAHY       NOV25p ------------------------------------------------------------       NOV25q ------------------------------------------------------------       NOV25r TGSNNKYKTTNQSTEFLSFQDASSLYRNILEKERELQQLGITEYLRKNIAQLQPDMEAHY       NOV25s TGSNMKYKTTNQSTEFLSFQDASSLYRNILEKERELQQLGITEYLRKNIAQLQPDMEAHY               NOV25a ---------------------------------------------------       NOV25b ---------------------------------------------------       NOV25c ---------------------------------------------------       NOV25d ---------------------------------------------------       NOV25e ---------------------------------------------------       NOV25f ---------------------------------------------------       NOV25g ---------------------------------------------------       NOV25h ---------------------------------------------------       NOV25i ---------------------------------------------------       NOV25j ---------------------------------------------------       NOV25k ---------------------------------------------------       NOV25l ---------------------------------------------------       NOV25m ---------------------------------------------------       NOV25n PGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLEVLEQQT       NOV25o PGAHEELKLMETLMYSRPRXVLVEQTKNEYFELKANLHAEPDYLEVLEQQT       NOV25p ---------------------------------------------------       NOV25q ---------------------------------------------------       NOV25r PGAHEELKLMETLMYSRPRXVLVEQTKNEYFELKANLHAEPDYLEVLEQQT       NOV25s PGAHEELKLMETLMYSRPRXVLVEQTKNEYFELKANLHAEPDYLEVLEQQT               NOV25a (SEQ ID NO: 566)       NOV25b (SEQ ID NO: 568)       NOV25c (SEQ ID NO: 570)       NOV25d (SEQ ID NO: 572)       NOV25e (SEQ ID NO: 574)       NOV25f (SEQ ID NO: 576)       NOV25g (SEQ ID NO: 578)       NOV25h (SEQ ID NO: 580)       NOV25i (SEQ ID NO: 582)       NOV25j (SEQ ID NO: 584)       NOV25k (SEQ ID NO: 586)       NOV25l (SEQ ID NO: 588)       NOV25m (SEQ ID NO: 590)       NOV25n (SEQ ID NO: 592)       NOV25o (SEQ ID NO: 594)       NOV25p (SEQ ID NO: 596)       NOV25q (SEQ ID NO: 598)       NOV25r (SEQ ID NO: 600)       NOV25s (SEQ ID NO: 602)                  
 
      Further analysis of the NOV25a protein yielded the following properties shown in Table 25C.  
               TABLE 25C                       Protein Sequence Properties NOV25a                                        SignalP analysis:   Cleavage site between residues 21 and 22       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 2; pos. chg 1; neg. chg 0           H-region:   length 25; peak value 8.53                         PSG score: 4.13       GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −3.75           possible cleavage site: between 15 and 16                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 0           number of TMS(s) . . . fixed                             PERIPHERAL   Likelihood = 1.48 (at 3)                         ALOM score: 1.48 (number of TMSs: 0)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 6           Charge difference: −2.0 C(0.5) − N(2.5)           N &gt;= C: N-terminal side will be inside       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   1   Hyd Moment(75):   5.82           Hyd Moment(95):   9.48   G content:   1           D/E content:   1   S/T content:   8                         Score: −1.79       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 38 SRG|SC                 NUCDISC: discrimination of nuclear localization signals                         pat4: RPRK (4) at 496           pat7: none           bipartite: none           content of basic residues: 9.2%           NLS Score: −0.22       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 94.1       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions       386 K   0.97       387 H   0.98       388 L   0.98       389 E   0.98       390 E   0.98       391 E   0.98       392 E   0.98       393 E   0.98       394 R   0.98       395 N   0.98       396 E   0.98       397 K   0.98       398 E   0.98       399 G   0.98       400 S   0.98       401 D   0.98       402 A   0.98       403 K   0.98       404 H   0.98       405 L   0.98       406 Q   0.98       407 R   0.98       408 S   0.98       409 L   0.98       410 L   0.98       411 E   0.98       412 Q   0.98       413 E   0.98       414 N   0.98       415 H   0.98       416 S   0.83           total: 31 residues                 Final Results (k = 9/23):                         52.2%: nuclear           26.1%: extracellular, including cell wall           21.7%: mitochondrial                 &gt;&gt; prediction for CG55033-04 is nuc (k = 23)                  
 
      A search of the NOV25a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 25D.  
               TABLE 25D                          Geneseq Results for NOV25a                                         NOV25a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length [Patent #,   Match   the Matched   Expect       Identifier   Date]   Residues   Region   Value               ABB53270   Human polypeptide #10 -  Homo     1 . . . 473   401/480 (83%)   0.0             sapiens , 841 aa. [WO200181363-A1,   1 . . . 475   412/480 (85%)           01-NOV-2001]       AAE22222   Human toll like receptor like molecule 5   1 . . . 473   401/480 (83%)   0.0           (TLR-L5) protein -  Homo sapiens , 841   1 . . . 475   412/480 (85%)           aa. [WO200220569-A2, 14-MAR-2002]       ABJ01956   158P1D7 SSH protein sequence SEQ   1 . . . 473   401/480 (83%)   0.0           ID No 657 - Unidentified, 841 aa.   1 . . . 475   412/480 (85%)           [WO200216593-A2, 28-FEB-2002]       ABJ05539   Breast cancer-associated protein 4 -   1 . . . 473   401/480 (83%)   0.0           Unidentified, 841 aa. [WO200259377-   1 . . . 475   412/480 (85%)           A2, 01-AUG-2002]       ABG78359   Human protein, homologous to IGFBP-   1 . . . 473   401/480 (83%)   0.0           ALS, designated NOV1a -  Homo     1 . . . 475   412/480 (85%)             sapiens , 841 aa. [WO200226826-A2,           04-APR-2002]                  
 
      In a BLAST search of public sequence databases, the NOV25a protein was found to have homology to the proteins shown in the BLASTP data in Table 25E.  
               TABLE 25E                          Public BLASTP Results for NOV25a                                         NOV25a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             CAD42380   Sequence 656 from Patent   1 . . . 473   401/480   (83%)   0.0           WO0216593 -  Homo sapiens     1 . . . 475   412/480   (85%)           (Human), 841 aa.       Q8BLLO   Hypothetical cysteine-rich flanking   1 . . . 381   339/381   (88%)   0.0           region -  Mus musculus  (Mouse),   1 . . . 380   358/381   (92%)           425 aa.       Q8C110   Hypothetical cysteine-rich flanking   1 . . . 381   339/381   (88%)   0.0           region -  Mus musculus  (Mouse),   1 . . . 380   358/381   (92%)           840 aa.       Q9H5Y7   Hypothetical protein FLJ22774 -   44 . . . 381    338/338   (100%)   0.0             Homo sapiens  (Human), 440 aa.   1 . . . 338   338/338   (100%)       BAC67207   Neuronal transmembrane protein   1 . . . 468   189/491   (38%)   2e−85           Slitrk4 -  Mus musculus  (Mouse),   30 . . . 493    265/491   (53%)           866 aa.                  
 
      PFam analysis predicts that the NOV25a protein contains the domains shown in the Table 25F.  
               TABLE 25F                          Domain Analysis of NOV25a                                             Identities/                       Similarities           Pfam   NOV25a   for the   Expect           Domain   Match Region   Matched Region   Value                       LRR   137 . . . 160   10/25 (40%)   0.13                   19/25 (76%)           LRRCT   218 . . . 268   17/54 (31%)   2.6e−08                   39/54 (72%)                      
 
     Example 26  
      The NOV26 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 26A.  
               TABLE 26A                       NOV26 Sequence Analysis                                                        NOV26a, CG55117-04   SEQ ID NO: 603   3766 bp               DNA Sequence   ORF Start: ATG at 10   ORF Stop: TGA at 2605                       TTGCTAGCT   ATG GCCCTCGTACTCGGCTCCCTGTTGCTGCTGGGGCTGTGCGGGAACTCCTTTTCAGG           AGGGCAGCCTTCATCCACAGATGCTCCTAAGGCTTGGAATTATGAATTGCCTGCAACAAATTATGAGA       CCCAAGACTCCCATAAAGCTGGACCCATTGGCATTCTCTTTGAACTAGTGCATATCTTTCTCTATGTG       GTACAGCCGCGTGATTTCCCAGAAGATACTTTGAGAAAATTCTTACAGAAGGCATATGAATCCAAAAT       TGATTATGACAAGCCAGAAACTGTAATCTTAGGTCTAAAGATTGTCTACTATGAAGCAGGGATTATTC       TATGCTGTGTCCTGGGGCTGCTGTTTATTATTCTGATGCCTCTGGTGAAGTATTTCTTTTGTATGTGT       CGTTGCTGTAACAAATGTGGTGGAGAAATGCACCAGCGACAGAAGGAAAATGGGCCCTTCCTGAGGAA       ATGCTTTGCAATCTCCCTGTTGGTGATTTGTATAATAATAAGCATTGGCATCTTCTATGGTTTTGTGG       CAAATCACCAGGTAAGAACCCGGATCAAAAGGAGTCGGAAACTGGCAGATAGCAATTTCAAGGACTTG       CGAACTCTCTTGAATGAAACTCCAGAGCAAATCAAATATATATTGGCCCAGTACAACACTACCAAGGA       CAAGGCGTTCACAGATCTGAACAGTATCAATTCAGTGCTAGGAGGCGGAATTCTTGACCGACTGAGAC       CCAACATCATCCCTGTTCTTGATGAGATTAAGTCCATGGCAACAGCGATCAAGGAGACCAAAGAGGCG       TTGGAGAACATGAACAGCACCTTGAAGAGCTTGCACCAACAAAGTACACAGCTTAGCAGCAGTCTGAC       CAGCGTGAAAACTAGCCTGCGGTCATCTCTCAATGACCCTCTGTGCTTGGTGCATCCATCAAGTGAAA       CCTGCAACAGCATCAGATTGTCTCTAAGCCAGCTGAATAGCAACCCTGAACTGAGGCAGCTTCCACCC       GTGGATGCAGAACTTGACAACGTTAATAACGTTCTTAGGACAGATTTGGATGGCCTGGTCCAACAGGG       CTATCAATCCCTTAATGATATACCTGACAGAGTACAACGCCAAACCACGACTGTCGTAGCAGGTATCA       AAAGGGTCTTGAATTCCATTGGTTCAGATATCGACAATGTAACTCAGCGTCTTCCTATTCAGGATATA       CTCTCAGCATTCTCTGTTTATGTTAATAACACTGAAAGTTACATCCACAGAAATTTACCTACATTGGA       AGAGTATGATTCATACTGGTGGCTGGGTGGCCTGGTCATCTGCTCTCTGCTGACCCTCATCGTGATTT       TTTACTACCTGGGCTTACTGTGTGGCGTGTGCGGCTATGACAGGCATAACACCCCGACCACCCGAGGC       TGTGTCTCCAACACCGGAGGCGTCTTCCTCATGGTTGGAGTTGGATTAAGTTTCCTCTTTTGCTGGAT       ATTGATGATCATTGTGGTTCTTACCTTTGTCTTTGGTGCAAATGTGGAAAAACTGATCTGTGAACCTT       ACACGAGCAAGGAATTATTCCGGGTTTTGGATACACCCTACTTACTAAATGAAGACTGGGAATACTAT       CTCTCTGGGAAGCTATTTAATAAATCAAAAATGAAGCTCACTTTTGAACAAGTTTACAGTGACTGCAA       AAAAAATAGAGGCACTTACGGCACTCTTCACCTGCAGAACAGCTTCAATATCAGTGAACATCTCAACA       TTAATGAGCATACTGGAAGCATAAGCAGTGAATTGGAAAGTCTGAAGGTAAATCTTAATATCTTTCTG       TTGGGTGCAGCAGGAAGAAAAAACCTTCAGGATTTTGCTGCTTGTGGAATAGACAGAATGAATTATGA       CAGCTACTTGGCTCAGACTGGTAAATCCCCCGCAGGAGTGAATCTTTTATCATTTGCATATGATCTAG       AAGCAAAAGCAAACAGTTTGCCCCCAGGAAATTTGAGGAACTCCCTGAAAAGAGATGCACAAACTATT       AAACAATTCACCAGCAACGAGTCCTTCCTATAGAACAATCACTGAGCACTCTATACCAAAAGCGTCAA       GATACTTCAACGCACAGGGAATGGATTGTTGGAGAGAGTAACTAGGATTCTAGCTTCTCTGGATTTTG       CTCAGAACTTCATCACAAACAATACTTCCTCTGTTATTATTGAGGAAACTAAGAAGTATGGGAGAACA       ATAATAGGATATTTTGAACATTATCTGCAGTGGATCGAGTTCTCTATCAGTGAGAAAGTGGCATCGTG       CAAACCTGTGGCCACCGCTCTAGATACTGCTGTTGATGTCTTTCTGTGTAGCTACATTATCGACCCCT       TGAATTTGTTTTGGTTTGGCATAGGAAAAGCTACTGTATTTTTACTTCCGGCTCTAATTTTTGCGGTA       AAACTGGCTAAGTACTATCGTCGAATGGATTCGGAGGACGTGTACGATGATGTTGAAACTATACCCAT       GAAAAATATGGAAAATGGTAATAATGGTTATCATAAAGATCATGTATATGGTATTCACAATCCTGTTA       TGACAAGCCCATCACAACAT TGA   TAGCTGATGTTGAAACTGCTTGAGCATCAGGATACTCAAAGTGGA           AAGGATCACAGATTTTTGGTAGTTTCTGGGTCTACAAGGACTTTCCAAATCCAGGAGCAACGCCAGTG           GCAACGTAGTGACTCAGGCGGGCACCAAGGCAACGGCACCATTGGTCTCTGGGTAGTGCTTTAAGAAT           GAACACAATCACGTTATAGTCCATGGTCCATCACTATTCAAGGATGACTCCCTCCCTTCCTGTCTATT           TTTGTTTTTTACTTTTTTACACTGAGTTTCTATTTAGACACTACAACATATGGGGTGTTTGTTCCCAT           TGGATGCATTTCTATCAAAACTCTATCAAATGTGATGGCTAGATTCTAACATATTGCCATGTGTGGAG           TGTGCTGAACACACACCAGTTTACAGGAAAGATGCATTTTGTGTACAGTAAACGGTGTATATACCTTT           TGTTACCACAGAGTTTTTTAAACAAATGAGTATTATAGGACTTTCTTCTAAATGAGCTAAATAAGTCA           CCATTGACTTCTTGGTGCTGTTGAAAATAATCCATTTTCACTAAAAGTGTGTGAAACCTACAGCATAT           TCTTCACGCAGAGATTTTCATCTATTATACTTTATCAAAGATTGGCCATGTTCCACTTGGAAATGGCA           TGCAAAAGCCATCATAGAGAAACCTGCGTAACTCCATCTGACAAATTCAAAAGAGAGAGAGAGATCTT           GAGAGAGAAATGCTGTTCGTTCAAAAGTGGAGTTGTTTTAACAGATGCCAATTACGGTGTACAGTTTA           ACAGAGTTTTCTGTTGCATTAGGATAAACATTAATTGGAGTGCAGCTAACATGAGTATCATCAGACTA           GTATCAAGTGTTCTAAAATGAAATATGAGAAGATCCTGTCACAATTCTTAGATCTGGTGTCCAGCATG           GATGAAACCTTTGAGTTTGGTCCCTAAATTTGCATGAAAGCACAAGGTAAATATTCATTTGCTTCAGG           AGTTTCATGTTGGATCTGTCATTATCAAAAGTGATCAGCAATGAAGAACTGGTCGGACAAAATTTAAC           GTTGATGTAATGGAATTCCAGATGTAGGCATTCCCCCCAGGTCTTTTCATGTGCAGATTGCAGTTCTG           ATTCATTTGAATAAAAAGGAACTTGG                                                   NOV26a, CG55117-04   SEQ ID NO: 604   865 aa   MW at 97200.8kD               Protein Sequence                     MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQP           RDFPEDTLRKFLQKAYESKIDYDKPETVILGLKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCC       NKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTL       LNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALEN       MNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDA       ELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSA       FSVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVS       NTGGVFLMVGVGLSFLFCWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSG       KLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGA       AGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTI       HQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIG       YFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGIGKATVFLLPALIFAVKWA       KYYRRMDSEDVYDDVETIPMKNMENGNNGYHKDHVYGIHNPVMTSPSQH                                             NOV26b, CG55117-01   SEQ ID NO: 605   3825 bp               DNA Sequence   ORF Start: ATG at 69   ORF Stop: TGA at 2664                       GNNNNNNANNNNATTCNTNCANTGNACNNNACCAAGTTCTACCTCATGTTTGGAGGATCTTGCTAGCT               ATG GCCCTCGTACTCGGCTCCCTGTTGCTGCTGGGGCTGTGCGGGAACTCCTTTTCAGGAGGGCAGCC       TTCATCCACAGATGCTCCTAAGGCTTGGAATTATGAATTGCCTGCAACAAATTATGAGACCCAAGACT       CCCATAAAGCTGGACCCATTGGCATTCTCTTTGAACTAGTGCATATCTTTCTCTATGTGGTACAGCCG       CGTGATTTCCCAGAAGATACTTTGAGAAAATTCTTACAGAAGGCATATGAATCCAAAATTGATTATGA       CAAGCCAGAAACTGTAATCTTAGGTCTAAAGATTGTCTACTATGAAGCAGGGATTATTCTATGCTGTG       TCCTGGGGCTGCTGTTTATTATTCTGATGCCTCTGGTGGGGTATTTCTTTTGTATGTGTCGTTGCTGT       AACAAATGTGGTGGAGAAATGCACCAGCGACAGAAGGAAAATGGGCCCTTCCTGAGGAAATGCTTTGC       AATCTCCCTGTTGGTGATTTGTATAATAATAAGCATTGGCATCTTCTATGGTTTTGTGGCAAATCACC       AGGTAAGAACCCGGATCAAAAGGAGTCGGAAACTGGCAGATAGCAATTTCAAGGACTTGCGAACTCTC       TTGAATGAAACTCCAGAGCAAATCAAATATATATTGGCCCAGTACAACACTACCAAGGACAAGGCGTT       CACAGATCTGAACAGTATCAATTCAGTGCTAGGAGGCGGAATTCTTGACCGACTGAGACCCAACATCA       TCCCTGTTCTTGATGAGATTAAGTCCATGGCAACAGCGATCAAGGAGACCAAAGAGGCGTTGGAGAAC       ATGAACAGCACCTTGAAGAGCTTGCACCAACAAAGTACACAGCTTAGCAGCAGTCTGACCAGCGTGAA       AACTAGCCTGCGGTCATCTCTCAATGACCCTCTGTGCTTGGTGCATCCATCAAGTGAAACCTGCAACA       GCATCAGATTGTCTCTAAGCCAGCTGAATAGCAACCCTGAACTGAGGCAGCTTCCACCCGTGGATGCA       GAACTTGACAACGTTAATAACGTTCTTAGGACAGATTTGGATGGCCTGGTCCAACAGGGCTATCAATC       CCTTAATGATATACCTGACAGAGTACAACGCCAAACCACGACTGTCGTAGCAGGTATCAAAAGGGTCT       TGAATTCCATTGGTTCAGATATCGACAATGTAACTCAGCGTCTTCCTATTCAGGATATACTCTCAGCA       TTCTCTGTTTATGTTAATAACACTGAAAGTTACATCCACAGAAATTTACCTACATTGGAAGAGTATGA       TTCATACTGGTGGCTGGGTGGCCTGGTCATCTGCTCTCTGCTGACCCTCATCGTGATTTTTTACTACC       TGGGCTTACTGTGTGGCGTGTGCGGCTATGACAGGCATGCCACCCCGACCACCCGAGGCTGTGTCTCC       AACACCGGAGGCGTCTTCCTCATGGTTGGAGTTGGATTAAGTTTCCTCTTTTGCTGGATATTGATGAT       CATTGTGGTTCTTACCTTTGTCTTTGGTGCAAATGTGGAAAAACTGATCTGTGAACCTTACACGAGCA       AGGAATTATTCCGGGTTTTGGATACACCCTACTTACTAAATGAAGACTGGGAATACTATCTCTCTGGG       AAGCTATTTAATAAATCAAAAATGAAGCTCACTTTTGAACAAGTTTACAGTGACTGCAAAAAAAATAG       AGGCACTTACGGCACTCTTCACCTGCAGAACAGCTTCAATATCAGTGAACATCTCAACATTAATGAGC       ATACTGGAAGCATAAGCAGTGAATTGGAAAGTCTGAAGGTAAATCTTAATATCTTTCTGTTGGGTGCA       GCAGGAAGAAAAAACCTTCAGGATTTTGCTGCTTGTGGAATAGACAGAATGAATTATGACAGCTACTT       GGCTCAGACTGGTAAATCCCCCGCAGGAGTGAATCTTTTATCATTTGCATATGATCTAGAAGCAAAAG       CAAACAGTTTGCCCCCAGGAAATTTGAGGAACTCCCTGA~AAGAGATGCACAAACTATTAAAACAATT       CACCAGCAACGAGTCCTTCCTATAGAACAATCACTGAGCACTCTATACCAAAGCGTCAAGATACTTCA       ACGCACAGGGAATGGATTGTTGGAGAGAGTAACTAGGATTCTAGCTTCTCTGGATTTTGCTCAGAACT       TCATCACAAACAATACTTCCTCTGTTATTATTGAGGAAACTAAGAAGTATGGGAGAACAATAATAGGA       TATTTTGAACATTATCTGCAGTGGATCGAGTTCTCTATCAGTGAGAAAGTGGCATCGTGCAAACCTGT       GGCCACCGCTCTAGATACTGCTGTTGATGTCTTTCTGTGTAGCTACATTATCGACCCCTTGAATTTGT       TTTGGTTTGGCATAGGAAAAGCTACTGTATTTTTACTTCCGGCTCTAATTTTTGCGGTAAAACTGGCT       AAGTACTATCGTCGAATGGATTCGGAGGACGTGTACGATGATGTTGAAACTATACCCATGAAAAATAT       GGAAAATGGTAATAATGGTTATCATAAAGATCATGTATATGGTATTCACAATCCTGTTATGACAAGCC       CATCACAACAT TGA   TAGCTGATGTTGAAACTGCTTGAGCATCAGGATACTCAAAGTGGAAAGGATCAC           AGATTTTTGGTAGTTTCTGGGTCTACAAGGACTTTCCAAATCCAGGAGCAACGCCAGTGGCAACGTAG           TGACTCAGGCGGGCACCAAGGCAACGGCACCATTGGTCTCTGGGTAGTGCTTTAAGAATGAACACAAT           CACGTTATAGTCCATGGTCCATCACTATTCAAGGATGACTCCCTCCCTTCCTGTCTATTTTTGTTTTT           TACTTTTTTACACTGAGTTTCTATTTAGACACTACAACATATGGGGTGTTTGTTCCCATTGGATGCAT           TTCTATCAAAACTCTATCAAATGTGATGGCTAGATTCTAACATATTGCCATGTGTGGAGTGTGCTGAA           CACACACCAGTTTACAGGAAAGATGCATTTTGTGTACAGTAAACGGTGTATATACCTTTTGTTACCAC           AGAGTTTTTTAAACAAATGAGTATTATAGGACTTTCTTCTAAATGAGCTAAATAAGTCACCATTGACT           TCTTGGTGCTGTTGAAAATAATCCATTTTCACTAAAAGTGTGTGAAACCTACAGCATATTCTTCACGC           AGAGATTTTCATCTATTATACTTTATCAAAGATTGGCCATGTTCCACTTGGAAATGGCATGCAAAAGC           CATCATAGAGAAACCTGCGTAACTCCATCTGACAAATTCAAAAGAGAGAGAGAGATCTTGAGAGAGAA           ATGCTGTTCGTTCAAAAGTGGAGTTGTTTTAACAGATGCCAATTACGGTGTACAGTTTAACAGAGTTT           TCTGTTGCATTAGGATAAACATTAATTGGAGTGCAGCTAACATGAGTATCATCAGACTAGTATCAAGT           GTTCTAAAATGAAATATGAGAAGATCCTGTCACAATTCTTAGATCTGGTGTCCAGCATGGATGAAACC           TTTGAGTTTGGTCCCTAAATTTGCATGAAAGCACAAGGTAAATATTCATTTGCTTCAGGAGTTTCATG           TTGGATCTGTCATTATCAAAAGTGATCAGCAATGAAGAACTGGTCGGACAAAATTTAACGTTGATGTA           ATGGAATTCCAGATGTAGGCATTCCCCCCAGGTCTTTTCATGTGCAGATTGCAGTTCTGATTCATTTG           AATAAAAAGGAACTTGG                                                   NOV26b, CG55117-01   SEQ ID NO: 606   865 aa   MW at 97200.8kD               Protein Sequence                     MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQP           RDFPEDTLRKFLQKAYESKIDYDKPETVILGLKIVYYEAGIILCCVLGLLFIILMPLVGYFFCNCRCC       NKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTL       LNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALEN       MNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDA       ELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSA       FSVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVS       NTGGVFLMVGVGLSFLFCWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSG       KLFNKSKNKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGA       AGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRNAQTIKTI       HQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIG       YFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGIGKATVFLLPALIFAVKLA       KYYRRMDSEDVYDDVETIPMMENGNNGYHKDHVYGIHNPVMTSPSQH                                             NOV26c, CG55117-02   SEQ ID NO: 607   756 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     CAGGTAAGAACCCGGATCAAAAGGAGTCGGAAACTGGCAGATAGCAATTTCAAGGACTTGCGAACTCT           CTTGAATGAAACTCCAGAGCAAATCAAATATATATTGGCCCAGTACAACACTACCAAGGACAAGGCGT       TCACAGATCTGAACAGTATCAATTCAGTGCTAGGAGGCGGAATTCTTGACCGACTGAGACCCAACATC       ATCCCTGTTCTTGATGAGATTAAGTCCATGGCAACAGCGATCAAGGAGACCAAAGAGGCGTTGGAGAA       CATGAACAGCACCTTGAAGAGCTTGCACCAACAAAGTACACAGCTTAGCAGCAGTCTGACCAGCGTGA       AAACTAGCCTGCGGTCATCTCTCAATGACCCTCTGTGCTTGGTGCATCCATCAAGTGAAACCTGCAAC       AGCATCAGATTGTCTCTAAGCCAGCTGAATAGCAACCCTGAACTGAGGCAGCTTCCACCCGTGGATGC       AGAACTTGACAACGTTAATAACGTTCTTAGGACAGATTTGGATGGCCTGGTCCAACAGGGCTATCAAT       CCCTTAATGATATACCTGACAGAGTACAACGCCAAACCACGACTGTCGTAGCAGGTATCAAAAGGGTC       TTGAATTCCATTGGTTCAGATATCGACAATGTAACTCAGCGTCTTCCTATTCAGGATATACTCTCAGC       ATTCTCTGTTTATGTTAATAACACTGAAAGTTACATCCACAGAAATTTACCTACATTGGAAGAGTATG       ATTCATAC                                                 NOV26c, CG55117-02   SEQ ID NO: 608   252 aa   MW at 28267.5kD               Protein Sequence                     QVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNI           IPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCN       SIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRV       LNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSY                                             NOV26d, CG55117-03   SEQ ID NO: 609   765 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     TGTGAACCTTACACGAGCAAGGAATTATTCCGGGTTTTGGATACACCCTACTTACTAAATGAAGACTG           GGAATACTATCTCTCTGGGAAGCTATTTAATAAATCAAAAATGAAGCTCACTTTTGAACAAGTTTACA       GTGACTGCAAAAAAAATAGAGGCACTTACGGCACTCTTCACCTGCAGAACAGCTTCAATATCAGTGAA       TATCTTTCTGTTGGGTGCAGCAGGAAGAAAAAACCTTCAGGATTTTGCTGCTTGTGGAATAGACAGAA       TGAATTATGACAGCTACTTGGCTCAGACTGGTAAATCCCCCGCAGGAGTGAATCTTTTATCATTTGCA       TATGATCTAGAAGCAAAAGCAAACAGTTTGCCCCCAGGAAATTTGAGGAACTCCCTGAAAAGAGATGC       ACAAACTATTAAAACAATTCACCAGCAACGAGTCCTTCCTATAGAACAATCACTGAGCACTCTATACC       AAAGCGTCAAGATACTTCAACGCACAGGGAATGGATTGTTGGAGAGAGTAACTAGGATTCTAGCTTCT       CTGGATTTTGCTCAGAACTTCATCACAAACAATACTTCCTCTGTTATTATTGAGGAAACTAAGAAGTA       TGGGAGAACAATAATAGGATATTTTGAACATTATCTGCAGTGGATCGAGTTCTCTATCAGTGAGAAAG       TGGCATCGTGCAAACCT                                                 NOV26d, CG55117-03   SEQ ID NO: 610   255 aa   MW at 28999.6kD               Protein Sequence                     CEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISE           HLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFA       YDLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILAS       LDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKP                                             NOV26e, CG55117-05   SEQ ID NO: 611   2523 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 2518                       GGATCC GGAGGGCAGCCTTCATCCACAGATGCTCCTAAGGCTTGGAATTATGAATTGCCTGCAACAAA           TTATGAGACCCAAGACTCCCATAAAGCTGGACCCATTGGCATTCTCTTTGAACTAGTGCATATCTTTC       TCTATGTGGTACAGCCGCGTGATTTCCCAGAAGATACTTTGAGAAAATTCTTACAGAAGGCATATGAA       TCCAAAATTGATTATGACAAGATTGTCTACTATGAAGCAGGGATTATTCTATGCTGTGTCCTGGGGCT       GCTGTTTATTATTCTGATGCCTCTGGTGGGGTATTTCTTTTGTATGTGTCGTTGCTGTAACAAATGTG       GTGGAGAAATGCACCAGCGACAGAAGGAAAATGGGCCCTTCCTGAGGAAATGCTTTGCAATCTCCCTG       TTGGTGATTTGTATAATAATAAGCATTGGCATCTTCTATGGTTTTGTGGCAAATCACCAGGTAAGAAC       CCGGATCAAAAGGAGTCGGAAACTGGCAGATAGCAATTTCAAGGACTTGCGAACTCTCTTGAATGAAA       CTCCAGAGCAAATCAAATATATATTGGCCCAGTACAACACTACCAAGGACAAGGCGTTCACAGATCTG       AACAGTATCAATTCAGTGCTAGGAGGCGGAATTCTTGACCGACTGAGACCCAACATCATCCCTGTTCT       TGATGAGATTAAGTCCATGGCAACAGCGATCAAGGAGACCAAAGAGGCGTTGGAGAACATGAACAGCA       CCTTGAAGAGCTTGCACCAACAAAGTACACAGCTTAGCAGCAGTCTGACCAGCGTGAAAACTAGCCTG       CGGTCATCTCTCAATGACCCTCTGTGCTTGGTGCATCCATCAAGTGAAACCTGCAACAGCATCAGATT       GTCTCTAAGCCAGCTGAATAGCAACCCTGAACTGAGGCAGCTTCCACCCGTGGATGCAGAACTTGACA       ACGTTAATAACGTTCTTAGGACAGATTTGGATGGCCTGGTCCAACAGGGCTATCAATCCCTTAATGAT       ATACCTGACAGAGTACAACGCCAAACCACGACTGTCGTAGCAGGTATCAAAAGGGTCTTGAATTCCAT       TGGTTCAGATATCGACAATGTAACTCAGCGTCTTCCTATTCAGGATATACTCTCAGCATTCTCTGTTT       ATGTTAATAACACTGAAAGTTACATCCACAGAAATTTACCTACATTGGAAGAGTATGATTCATACTGG       TGGCTGGGTGGCCTGGTCATCTGCTCTCTGCTGACCCTCATCGTGATTTTTTACTACCTGGGCTTACT       GTGTGGCGTGTGCGGCTATGACAGGCATGCCACCCCGACCACCCGAGGCTGTGTCTCCAACACCGGAG       GCGTCTTCCTCATGGTTGGAGTTGGATTAAGTTTCCTCTTTTGCTGGATATTGATGATCATTGTGGTT       CTTACCTTTGTCTTTGGTGCAAATGTGGAAAAACTGATCTGTGAACCTTACACGAGCAAGGAATTATT       CCGGGTTTTGGATACACCCTACTTACTAAATGAAGACTGGGAATACTATCTCTCTGGGAAGCTATTTA       ATAAATCAAAAATGAAGCTCACTTTTGAACAAGTTTACAGTGACTGCAAAAAAAATAGAGGCACTTAC       GGCACTCTTCACCTGCAGAACAGCTTCAATATCAGTGAACATCTCAACATTAATGAGCATACTGGAAG       CATAAGCAGTGAATTGGAAAGTCTGAAGGTAAATCTTAATATCTTTCTGTTGGGTGCAGCAGGAAGAA       AAAACCTTCAGGATTTTGCTGCTTGTGGAATAGACAGAATGGATTATGACAGCTACTTGGCTCAGACT       GGTAAATCCCCCGCAGGAGTGAATCTTTTATCATTTGCATATGATCTAGAAGCAAAAGCAAACAGTTT       GCCCCCAGGAAATTTGAGGAACTCCCTGAAAAGAGATGCACAAACTATTAAAACAATTCACCAGCAAC       GAGTCCTTCCTATAGAACAATCACTGAGCACTCTATACCAAAGCGTCAAGATACTTCAACGCACAGGG       AATGGATTGTTGGAGAGAGTAACTAGGACTCTAGCTTCTCTGGATTTTGCTCAGAACTTCATCACAAA       CAATACTTCCTCTGTTATTATTGAGGAAACTAAGAAGTATGGGAGGACAATAATAGGATATTTTGAAC       ATTATCTGCAGTGGATCGAGTTCTCTATCAGTGAGAAAGTGGCATCGTGCAAACCTGTGGCCACCGCT       CTAGATACTGCTGTTGATGTCTTTCTGTGTAGCTACATTATCGACCCCTTGAATTTGTTTTGGTTTGG       CATAGGAAAAGCTACTGTATTTTTACTTCCGGCTCTAATTTTTGCGGTAAAACTGGCTAAGTACTATC       GTCGAATGGATTCGGAGGACGTGTACGATGATGTTGAAACTATACCCATGAAAAATATGGAAAATGGT       AATAATGGTTATCATAAAGATCATGTATATGGTATTCACAATCCTGTTATGACAAGCCCATCACAACA       TCTC GAG                                                   NOV26e, CG55117-05   SEQ ID NO: 612   837 aa   MW at 94348.3kD               Protein Sequence                     GGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESK           IDYDKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLV       ICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNS       INSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRS       SLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIP       DRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSYWWL       GGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLFCWILMIIVVLT       FVFGANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGT       LHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAACGIDRMDYDSYLAQTGK       SPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNG       LLERVTRTLASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALD       TAVDVFLCSYIIDPLNLFWFGIGKATVFLLPALIFAVKLAKYYRRMDSEDVYDDVETIPMKNMENGNN       GYHKDHVYGIHNPVMTSPSQH                                     NOV26f, SNP13382440 of   SEQ ID NO: 613   3766 bp           CG55117-04, DNA Sequence   ORF Start: ATG at 10   ORF Stop: TGA at 2605           SNP Pos: 3274   SNP Change: C to A                       TTGCTAGCT   ATG GCCCTCGTACTCGGCTCCCTGTTGCTGCTGGGGCTGTGCGGGAACTCCTTTTCAGG           AGGGCAGCCTTCATCCACAGATGCTCCTAAGGCTTGGAATTATGAATTGCCTGCAACAAATTATGAGA       CCCAAGACTCCCATAAAGCTGGACCCATTGGCATTCTCTTTGAACTAGTGCATATCTTTCTCTATGTG       GTACAGCCGCGTGATTTCCCAGAAGATACTTTGAGAAAATTCTTACAGAAGGCATATGAATCCAAAAT       TGATTATGACAAGCCAGAAACTGTAATCTTAGGTCTAAAGATTGTCTACTATGAAGCAGGGATTATTC       TATGCTGTGTCCTGGGGCTGCTGTTTATTATTCTGATGCCTCTGGTGGGGTATTTCTTTTGTATGTGT       CGTTGCTGTAACAAATGTGGTGGAGAAATGCACCAGCGACAGAAGGAAAATGGGCCCTTCCTGAGGAA       ATGCTTTGCAATCTCCCTGTTGGTGATTTGTATAATAATAAGCATTGGCATCTTCTATGGTTTTGTGG       CAAATCACCAGGTAAGAACCCGGATCAAAAGGAGTCGGAAACTGGCAGATAGCAATTTCAAGGACTTG       CGAACTCTCTTGAATGAAACTCCAGAGCAAATCAAATATATATTGGCCCAGTACAACACTACCAAGGA       CAAGGCGTTCACAGATCTGAACAGTATCAATTCAGTGCTAGGAGGCGGAATTCTTGACCGACTGAGAC       CCAACATCATCCCTGTTCTTGATGAGATTAAGTCCATGGCAACAGCGATCAAGGAGACCAAAGAGGCG       TTGGAGAACATGAACAGCACCTTGAAGAGCTTGCACCAACAAAGTACACAGCTTAGCAGCAGTCTGAC       CAGCGTGAAAACTAGCCTGCGGTCATCTCTCAATGACCCTCTGTGCTTGGTGCATCCATCAAGTGAAA       CCTGCAACAGCATCAGATTGTCTCTAAGCCAGCTGAATAGCAACCCTGAACTGAGGCAGCTTCCACCC       GTGGATGCAGAACTTGACAACGTTAATAACGTTCTTAGGACAGATTTGGATGGCCTGGTCCAACAGGG       CTATCAATCCCTTAATGATATACCTGACAGAGTACAACGCCAAACCACGACTGTCGTAGCAGGTATCA       AAAGGGTCTTGAATTCCATTGGTTCAGATATCGACAATGTAACTCAGCGTCTTCCTATTCAGGATATA       CTCTCAGCATTCTCTGTTTATGTTAATAACACTGAAAGTTACATCCACAGAAATTTACCTACATTGGA       AGAGTATGATTCATACTGGTGGCTGGGTGGCCTGGTCATCTGCTCTCTGCTGACCCTCATCGTGATTT       TTTACTACCTGGGCTTACTGTGTGGCGTGTGCGGCTATGACAGGCATGCCACCCCGACCACCCGAGGC       TGTGTCTCCAACACCGGAGGCGTCTTCCTCATGGTTGGAGTTGGATTAAGTTTCCTCTTTTGCTGGAT       ATTGATGATCATTGTGGTTCTTACCTTTGTCTTTGGTGCAAATGTGGAAAAACTGATCTGTGAACCTT       ACACGAGCAAGGAATTATTCCGGGTTTTGGATACACCCTACTTACTAAATGAAGACTGGGAATACTAT       CTCTCTGGGAAGCTATTTAATAAATCAAAAATGAAGCTCACTTTTGAACAAGTTTACAGTGACTGCAA       AAAAAATAGAGGCACTTACGGCACTCTTCACCTGCAGAACAGCTTCAATATCAGTGAACATCTCAACA       TTAATGAGCATACTGGAAGCATAAGCAGTGAATTGGAAAGTCTGAAGGTAAATCTTAATATCTTTCTG       TTGGGTGCAGCAGGAAGAAAAAACCTTCAGGATTTTGCTGCTTGTGGAATAGACAGAATGAATTATGA       CAGCTACTTGGCTCAGACTGGTAAATCCCCCGCAGGAGTGAATCTTTTATCATTTGCATATGATCTAG       AAGCAAAAGCAAACAGTTTGCCCCCAGGAAATTTGAGGAACTCCCTGAAAAGAGATGCACAAACTATT       AAAACAATTCACCAGCAACGAGTCCTTCCTATAGAACAATCACTGAGCACTCTATACCAAAGCGTCAA       GATACTTCAACGCACAGGGAATGGATTGTTGGAGAGAGTAACTAGGATTCTAGCTTCTCTGGATTTTG       CTCAGAACTTCATCACAAACAATACTTCCTCTGTTATTATTGAGGAAACTAAGAAGTATGGGAGAACA       ATAATAGGATATTTTGAACATTATCTGCAGTGGATCGAGTTCTCTATCAGTGAGAAAGTGGCATCGTG       CAAACCTGTGGCCACCGCTCTAGATACTGCTGTTGATGTCTTTCTGTGTAGCTACATTATCGACCCCT       TGAATTTGTTTTGGTTTGGCATAGGAAAAGCTACTGTATTTTTACTTCCGGCTCTAATTTTTGCGGTA       AAACTGGCTAAGTACTATCGTCGAATGGATTCGGAGGACGTGTACGATGATGTTGAAACTATACCCAT       GAAAAATATGGAAAATGGTAATAATGGTTATCATAAAGATCATGTATATGGTATTCACAATCCTGTTA       TGACAAGCCCATCACAACAT TGA   TAGCTGATGTTGAAACTGCTTGAGCATCAGCATACTCAAAGTGGA           AAGGATCACAGATTTTTGGTAGTTTCTGGGTCTACAAGGACTTTCCAAATCCAGGAGCAACGCCAGTG           GCAACGTAGTGACTCAGGCGGGCACCAAGGCAACGGCACCATTGGTCTCTGGGTAGTGCTTTAAGAAT           GAACACAATCACGTTATAGTCCATGGTCCATCACTATTCAAGGATGACTCCCTCCCTTCCTGTCTATT           TTTGTTTTTTACTTTTTTACACTGAGTTTCTATTTAGACACTACAACATATGGGGTGTTTGTTCCCAT           TGGATGCATTTCTATCAAAACTCTATCAAATGTGATGGCTAGATTCTAACATATTGCCATGTGTGGAG           TGTGCTGAACACACACCAGTTTACAGGAAAGATGCATTTTGTGTACAGTAAACGGTGTATATACCTTT           TGTTACCACAGAGTTTTTTAAACAAATGAGTATTATAGGACTTTCTTCTAAATGAGCTAAATAAGTCA           CCATTGACTTCTTGGTGCTGTTGAAAATAATCCATTTTCACTAAAAGTGTGTGAAACCTACAGCATAT           TCTTCACGCAGAGATTTTCATCTATTATACTTTATCAAAGATTGGCCATGTTCCACTTGGAAATGGCA           TGCAAAAGC A ATCATAGAGAAACCTGCGTAACTCCATCTGACAAATTCAAAAGAGAGAGAGAGATCTT           GAGAGAGAAATGCTGTTCGTTCAAAAGTGGAGTTGTTTTAACAGATGCCAATTACGGTGTACAGTTTA           ACAGAGTTTTCTGTTGCATTAGGATAAACATTAATTGGAGTGCAGCTAACATGAGTATCATCAGACTA           GTATCAAGTGTTCTAAAATGALATATGAGAAGATCCTGTCACAATTCTTAGATCTGGTGTCCAGCATG           GATGAAACCTTTGAGTTTGGTCCCTAAATTTGCATGAAAGCACAAGGTAAATATTCATTTGCTTCAGG           AGTTTCATGTTGGATCTGTCATTATCAAAAGTGATCAGCAATGAAGAACTGGTCGGACAAAATTTAAC           GTTGATGTAATGGAATTCCAGATGTAGGCATTCCCCCCAGGTCTTTTCATGTGCAGATTGCAGTTCTG           ATTCATTTGAATAAAAAGGAACTTGG                                           NOV26f, SNP13382440 of   SEQ ID NO: 614   865 aa   MW at 97200.8kD           CG55117-04, Protein           SNP Change: no change       Sequence                     MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQP           RDFPEDTLRXFLQKAYESKIDYDKPETVILGLKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCC       NKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTL       LNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALEN       MNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDA       ELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSA       FSVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVS       NTGGVFLMVGVGLSFLFCWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSG       KLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGA       AGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTI       HQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIG       YFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGIGKATVFLLPALIFAVKLA       KYYRRMDSEDVYDDVETIPMKNMENGNNGYHKDHVYGIHNPVMTSPSQH                                     NOV26g, SNP13382439 of   SEQ ID NO: 615   3766 bp           CG55117-04, DNA Sequence   ORF Start: ATG at 10   ORF Stop: TGA at 2605           SNP Pos: 3685   SNP Change: G to A                       TTGCTAGCT   ATG GCCCTCGTACTCGGCTCCCTGTTGCTGCTGGGGCTGTGCGGGAACTCCTTTTCAGG           AGGGCAGCCTTCATCCACAGATGCTCCTAAGGCTTGGAATTATGAATTGCCTGCAACAAATTATGAGA       CCCAAGACTCCCATAAAGCTGGACCCATTGGCATTCTCTTTGAACTAGTGCATATCTTTCTCTATGTG       GTACAGCCGCGTGATTTCCCAGAAGATACTTTGAGAAAATTCTTACAGAAGGCATATGAATCCAAAAT       TGATTATGACAAGCCAGAAACTGTAATCTTAGGTCTAAAGATTGTCTACTATGAAGCAGGGATTATTC       TATGCTGTGTCCTGGGGCTGCTGTTTATTATTCTGATGCCTCTGGTGGGGTATTTCTTTTGTATGTGT       CGTTGCTGTAACAAATGTGGTGGAGAAATGCACCAGCGACAGAAGGAAAATGGGCCCTTCCTGAGGAA       ATGCTTTGCAATCTCCCTGTTGGTGATTTGTATAATAATAAGCATTGGCATCTTCTATGGTTTTGTGG       CAAATCACCAGGTAAGAACCCGGATCAAAAGGAGTCGGAAACTGGCAGATAGCAATTTCAAGGACTTG       CGAACTCTCTTGAATGAAACTCCAGAGCPAATCAAATATATATTGGCCCAGTACAACACTACCAAGGA       CAAGGCGTTCACAGATCTGAACAGTATCAATTCAGTGCTAGGAGGCGGAATTCTTGACCGACTGAGAC       CCAACATCATCCCTGTTCTTGATGAGATTAAGTCCATGGCAACAGCGATCAAGGAGACCAAAGAGGCG       TTGGAGAACATGAACAGCACCTTGAAGAGCTTGCACCAACAAAGTACACAGCTTAGCAGCAGTCTGAC       CAGCGTGAAAACTAGCCTGCGGTCATCTCTCAATGACCCTCTGTGCTTGGTGCATCCATCAAGTGAAA       CCTGCAACAGCATCAGATTGTCTCTAAGCCAGCTGAATAGCAACCCTGAACTGAGGCAGCTTCCACCC          
 
      Further analysis of the NOV26a protein yielded the following properties shown in Table 26C.  
               TABLE 26C                       Protein Sequence Properties NOV26a                                        SignalP analysis:   Cleavage site between residues 20 and 21       PSORTII analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 0; pos. chg 0; neg. chg 0           H-region:   length 26; peak value 9.51           PSG score:   5.11                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 2.78           possible cleavage site: between 19 and 20                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 19)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 20           Tentative number of TMS(s) for the threshold 0.5: 6                                 INTEGRAL   Likelihood =   Transmembrane  50-66                −3.08           INTEGRAL   Likelihood =   Transmembrane 109-125               −13.69           INTEGRAL   Likelihood =   Transmembrane 158-174               −12.90           INTEGRAL   Likelihood =   Transmembrane 435-451                −8.55           INTEGRAL   Likelihood =   Transmembrane 491-507               −13.06           INTEGRAL   Likelihood =   Transmembrane 797-813                −3.13                             PERIPHERAL   Likelihood = 0.90 (at 772)                         ALOM score: −13.69 (number of TMSs: 6)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 9           Charge difference: −2.0 C(−1.0)-N(1.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 3a                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   0.43           Hyd Moment(95):   2.59   G content:   5           D/E content:   1   S/T content:   6                         Score: −6.77       Gavel:   Prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 9.5%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs:                         Leucine zipper pattern (PS00029): *** found ***            LPPVDAELDNVNNVLRTDLDGL at 335                 none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 76.7       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions       251 V   0.95       252 L   0.99       253 D   0.99       254 E   0.99       255 I   0.99       256 K   0.99       257 S   0.99       258 M   0.99       259 A   0.99       260 T   0.99       261 A   0.99       262 I   0.99       263 K   0.99       264 E   0.99       265 T   0.99       266 K   0.99       267 E   0.99       268 A   0.99       269 L   0.99       270 E   0.99       271 N   0.99       272 M   0.99       273 N   0.99       274 S   0.99       275 T   0.99       276 L   0.99       277 K   0.99       278 S   0.99       279 L   0.99       280 H   0.98       281 Q   0.98       282 Q   0.97       283 S   0.90       284 T   0.90       285 Q   0.90       286 L   0.90       287 S   0.90       288 S   0.90       289 S   0.89       290 L   0.89       291 T   0.67       292 S   0.51       293 V   0.51       294 K   0.51           total: 44 residues                 Final Results (k = 9/23):                         77.8%: endoplasmic reticulum           22.2%: mitochondrial                 &gt;&gt; prediction for CG55117-04 is end (k = 9)                  
 
      A search of the NOV26a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 26D.  
               TABLE 26D                          Geneseq Results for NOV26a                                         NOV26a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               ABJ37079   Human breast cancer/ovarian cancer   1 . . . 865   865/865 (100%)   0.0           related protein #55 -  Homo sapiens ,   1 . . . 865   865/865 (100%)           865 aa. [WO2003000012-A2, 03-JAN-           2003]       ABB82955   Human PROML related protein   1 . . . 865   865/865 (100%)   0.0           (GenBank Identifier No. GI#131214442) -   1 . . . 865   865/865 (100%)             Homo sapiens , 865 aa.           [WO200299047-A2, 12-DEC-2002]       ABB82954   Human PROML related protein   1 . . . 865   865/865 (100%)   0.0           (GenBank Identifier No. GI#5174387) -   1 . . . 865   865/865 (100%)             Homo sapiens , 865 aa.           [WO200299047-A2, 12-DEC-2002]       ABB82953   Human PROML related protein   1 . . . 865   865/865 (100%)   0.0           (GenBank Identifier No. GI#7512271) -   1 . . . 865   865/865 (100%)             Homo sapiens , 865 aa.           [WO200299047-A2, 12-DEC-2002]       AAU79943   Human AC133 antigen-like protein   1 . . . 865   865/865 (100%)   0.0           NOV5 -  Homo sapiens , 865 aa.   1 . . . 865   865/865 (100%)           [WO200229038-A2, 11-APR-2002]                  
 
      In a BLAST search of public sequence databases, the NOV26a protein was found to have homology to the proteins shown in the BLASTP data in Table 26E.  
               TABLE 26E                          Public BLASTP Results for NOV26a                                         NOV26a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             O43490   Prominin-like protein 1 precursor   1 . . . 865   865/865   (100%)   0.0           (Antigen AC133) (CD133 antigen) -   1 . . . 865   865/865   (100%)             Homo sapiens  (Human), 865 aa.       Q96EN6   Similar to prominin (Mouse)-like 1   1 . . . 865   856/865   (98%)   0.0           (AC133-2 antigen) (MSTP061) -   1 . . . 856   856/865   (98%)             Homo sapiens  (Human), 856 aa.       Q91XN5   Prominin -  Rattus norvegicus  (Rat),   1 . . . 865   528/866   (60%)   0.0           857 aa.   1 . . . 857   681/866   (77%)       O54990   Prominin-like protein 1 precursor   1 . . . 865   526/867   (60%)   0.0           (Antigen AC133 homolog) -  Mus      1 . . . 867   683/867   (78%)             musculus  (Mouse), 867 aa.       T08881   prominin - mouse, 858 aa.   1 . . . 865   521/867   (60%)   0.0               1 . . . 858   676/867   (77%)                  
 
      PFam analysis predicts that the NOV26a protein contains the domains shown in the Table 26F.  
               TABLE 26F                       Domain Analysis of NOV26a                                                        Pfam   NOV26a   Identities/   Expect           Domain   Match Region   Similarities for   Value                   the Matched Region                      
 
     Example 27  
      The MOV27 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 27A.  
               TABLE 27A                       NOV27 Sequence Analysis                                                        NOV27a, CG55193-04   SEQ ID NO: 617   1336 bp               DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 1327                       ATG GGTCTGGCCATGGAGCACGGAGGGTCCTACGCTCGGGCGGGGGGCAGCTCTCGGGGCTGCTGGTA           TTACCTGCGCTACTTCTTCCTCTTCGTCTCCCTCATCCAATTCCTCATCATCCTGGGGCTCGTGCTCT       TCATGGTCTATGGCAACGTGCACGTGAGCACAGAGTCCAACCTGCAGGCCACCGAGCGCCGAGCCGAG       GGCCTATACAGTCAGCTCCTAGGGCTCACGGCCTCCCAGTCCAACTTGACCAAGGAGCTCAACTTCAC       CACCCGCGCCAAGGATGCCATCATGCAGATGTGGCTGAATGCTCGCCGCGACCTGGACCGCATCAATG       CCAGCTTCCGCCAGTGCCAGGGTGACCGGGTAATCTACACGAACAATCAGAGGTACATGGCTGCCATC       ATCTTGAGTGAGAAGCAATGCAGAGATCAATTCAAGGACATGAACAAGAGCTGCGATGCCTTGCTCTT       CATGCTGAATCAGAAGGTGAAGACGCTGGAGGTGGAGATAGCCAAGGAGAAGACCATTTGCACTAAGG       ATAAGGAAAGCGTGCTGCTGAACAAACGCGTGGCGGAGGAACAGCTGGTTGAATGCGTGAAAACCCGG       GAGCTGCAGCACCAAGAGCGCCAGCTGGCCAAGGAGCAACTGCAAAAGGTGCAAGCCCTCTGCCTGCC       CCTGGACAAGGACAAGTTTGAGATGGACCTTCGTAACCTGTGGAGGGACTCCATTATCCCACGCAGCC       TGGACAACCTGGGTTACAACCTCTACCATCCCCTGGGCTCGGAATTGGCCTCCATCCGCAGAGCCTGC       GACCACATGCCCAGCCTCATGAGCTCCAAGGTGGAAGGTCAGTGCCGGAGCCTCCGGGCGGATATCGA       ACGCGTGGCCCGCGAGAACTCAGACCTCCAACGCCAGAAGCTGGAAGCCCAGCAGGGCCTGCGGGCCA       GTCAGGAGGCGAAACAGAAGGTGGAGAAGGAGGCTCAGGCCCGGGAGGCCAAGCTCCAAGCTGAATGC       TCCCGGCAGACCCAGCTAGCGCTGGAGGAGAAGGCGGTGCTGCGGAAGGAACGAGACAACCTGGCCAA       GGAGCTGGAAGAGAAGAAGAGGGAGGCGGAGCAGCTCAGGATGGAGCTGGCCATCAGAAACTCAGCCC       TGGACACCTGCATCAAGACCAAGTCGCAGCCGATGATGCCAGTGTCAAGGCCCATGGGCCCTGTCCCC       AACCCCCAGCCCATCGACCCAGCTAGCCTGGAGGAGTTCAAGAGGAAGATCCTGGAGTCCCAGAGGCC       CCCTGCAGGCATCCCTGTAGCCCCATCCAGTGGC TGA   GGAGGCT                                                   NOV27a, CG55193-04   SEQ ID NO: 618   442 aa   MW at 50568.7kD               Protein Sequence                     MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAE           GLYSQLLGLTASQSNLTKELNFTTPAKDAIMQMWLNARPDLDRINASFRQCQGDRVIYTNNQRYMAAI       ILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTR       ELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRAC       DHMPSLMSSKVEGQCRSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAEC       SRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVP       NPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG                                             NOV27b, 214575880   SEQ ID NO: 619   1188 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GGATCCAACGTGCACGTGAGCACAGAGTCCAACCTGCAGGCCACCGAGCACCGAGCCGAGGGCCTATA           CAGTCAGCTCCTAGGGCTCACGGCCTCCCAGTCCAACTTGACCAAGGAGCTCAACTTCACCACCCGCG       CCAAGGATGCCATCATGCAGATGTGGCTGAATGCTCGCCGCGACCTGGACCGCATCAATGCCAGCTTC       CGCCAGTGCCAGGGTGACCGGGTCATCTACACGAACAATCAGAGGTACATGGCTGCCATCATCTTGAG       TGAGAAGCAATGCAGAGATCAATTCAAGGACATGAACAAGAGCTGCGATGCCTTGCTCTTCATGCTGA       ATCAGAAGGTGAAGACGCTGGAGGTGGAGATAGCCAAGGAGAAGACCATTTGCACTAAGGATAAGGAA       AGCGTGCTGCTGAACAAACGCGTGGCGGAGGAACAGCTGGTTGAATGCGTGAAAACCCGGGAGCTGCA       GCACCAAGAGCGCCAGCTGGTCAAGGAGCAACTGCAAAAGGTGCAAGCCCTCTGCCTGCCCCTGGACA       AGGACAAGTTTGAGATGGACCTTCGTAACCTGTGGAGGGACTCCATTATCCCACGCAGCCTGGACAAC       CTGGGTTACAACCTCTACCATCCCCTGGGCTCGGAATTGGCCTCCATCCGCAGAGCCTGCGACCACAT       GCCCAGCCTCATGAGCTCCAAGGTGGAGGAGCTGGCCCGGAGCCTCCGGGCGGATATCGAACGCGTGG       TCCGCGAGAACTCAGACCTCCAACGCCAGAAGCTGGAAGCCCAGCAGGGCCTGCGGGCCAGTCAGGAG       GCGAAACAGAAGGTGGAGAAGGAGGCTCAGGCCCGGGAGGCCAAGCTCCAAGCTGAATGCTCCCGGCA       GACCCAGCTAGCGCTGGAGGAGAAGGCGGTGCTGCGGAGGGAACGAGACAACCTGGCCAAGGAGCTGG       AAGAGAAGAAGAGGGAGGCGGAGCAGCTCAGGATGGAGCTGGCCATCAGAAACTCAGCCCTGGACACC       TGCATCAAGACCAAGTCGCAGCCGATGATGCCAGTGTCAAGGCCCATGGGCCCTGTCCCCAACCCCCA       GCCCATCGACCCAGCTAGCCTGGAGGAGTTCAAGAGGAAGATCCTGGAGTCCCAGAGGCCCCCTGCAG       GCATCCCTGTAGCCCCATCCAGTGGCCTCGAG                                                 NOV27b, 214575880   SEQ ID NO: 620   396 aa   MW at 45387.5kD               Protein Sequence                     GSNVHVSTESNLQATEHRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASF           RQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKE       SVLLNKRVAEEQLVECVKTRELQHQERQLVKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDN       LGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVVRENSDLQRQKLEAQQGLRASQE       AKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRRERDNLAKELEEKKREAEQLRMELAIRNSALDT       CIKTKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSGLE                                             NOV27c, 214458684   SEQ ID NO: 621   1419 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GAGATTCCCCCCCCTCGGGTCTCTTGGGCCTGTCCATGCGCCCCCCCCTCCGTGCTCCATGGCCAGAC           CCATGGATCCATGGGTCTGGCCATGGAGCACGGAGGGTCCTACGCTCGGGCGGGGGGCAGCTCTCGGG       GCTGCTGGTATTACCTGCGCTACTTCTTCCTCTTCGTCTCCCTCATCCAATTCCTCATCATCCTGGGG       CTCGTGCTCTTCATGGTCTATGGCAACGTGCACGTGAGCACAGAGTCCAACCTGCAGGCCACCGAGCG       CCGAGCCGAGGGCCTATACAGTCAGCTCCTAGGGCTCACGGCCTCCCAGTCCAACTTGACCAAGGAGC       TCAACTTCACCACCCGCGCCAAGGATGCCATCATGCAGATGTGGCTGAATGCTCGCCGCGACCTGGAC       CGCATCAATGCCAGCTTCCGCCAGTGCCAGGGTGACCGGGTCATCTACACGAACAATCAGAGGTACAT       GGCTGCCATCATCTTGAGTGAGAAGCAATGCAGAGATCAATTCAAGGACATGAACAAGAGCTGCGATG       CCTTGCTCTTCATGCTGAATCAGAAGGTGAAGACGCTGGAGGTGGAGATAGCCAAGGAGAAGACCATT       TGCACTAAGGATAAGGAAAGCGTGCTGCTGAACAAACGCGTGGCGGAGGAACAGCTGGTTGAATGCGT       GAAAACCCGGGAGCTGCAGCACCAAGAGCGCCAGCTGGCCAAGGAGCAACTGCAAAAGGTGCAAGCCC       TCTGCCTGCCCCTGGACAAGGACAAGTTTGAGATGGACCTTCGTAACCTGTGGAGGGACTCCATTATC       CCACGCAGCCTGGACAACCTGGGTTACAACCTCTACCATCCCCTGGGCTCGGAATTGGCCTCCATCCG       CAGAGCCTGCGACCACATGCCCAGCCTCATGAGCTCCAAGGTGGAGGAGCTGGCCCGGAGCCTCCGGG       CGGATATCGAACGCGTGGCCCGCGAGAACTCAGACCTCCAACGCCAGAAGCTGGAAGCCCAGCAGGGC       CTGCGGGCCAGTCAGGAGGCGAAACAGAAGGTGGAGAAGGAGGCTCAGGCCCGGGAGGCCAAGCTCCA       AGCTGAATGCTCCCGGCAGACCCAGCTAGCGCTGGAGGAGAAGGCGGTGCTGCGGAAGGAACGAGACA       ACCTGGCCAAGGAGCTGGAAGAGAAGAAGAGGGAGGCGGAGCAGCTCAGGATGGAGCTGGCCATCAGA       AACTCAGCCCTGGACACCTGCATCAAGACCAAGTCGCAGCCGATGATGCCAGTGTCAAGGCCCATGGG       CCCTGTCCCCAACCCCCAGCCCATCGACCCAGCTAGCCTGGAGGAGTTCAAGAGGAAGATCCTGGAGT       CCCAGAGGCCCCCTGCAGGCATCCCTGTAGCCCCATCCAGTGGCCTCGAG                                                 NOV27c, 214458684   SEQ ID NO: 622   470 aa   MW at 53542.0kD               Protein Sequence                     EIPPPRVSWACPCAPPSVLHGQTHGSMGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILG           LVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLD       RINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTI       CTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSII       PRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQG       LRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIR       NSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSGLE                                             NOV27d, 214458688   SEQ ID NO: 623   1404 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     TTCGCCCTTGGATCCATGGGTCTGGCCATGGAGCACGGAGGGTCCTACGCTCGGGCGGGGGGCAGCTC           TCGGGGCTGCTGGTATTACCTGCGCTACTTCTTCCTCTTCGTCTCCCTCATCCAATTCCTCATCATCC       TGGGGCTCGTGCTCTTCATGGTCTATGGCAACGTGCACGTGAGCACAGAGTCCAACCTGCAGGCCACC       GAGCGCCGAGCCGAGGGCCTATACAGTCAGCTCCTAGGGCTCACGGCCTCCCAGTCCAACTTGACCAA       GGAGCTCAACTTCACCACCCGCGCCAAGGATGCCATCATGCAGATGTGGCTGAATGCTCGCCGCGACC       TGGACCGCATCAATGCCAGCTTCCGCCAGTGCCAGGGTGACCGGGTCATCTACACGAACAATCAGAGG       TACATGGCTGCCATCATCTTGAGTGAGAAGCAATGCAGAGATCAATTCAAGGACATGAACAAGAGCTG       CGATGCCTTGCTCTTCATGCTGAATCAGAAGGTGAAGACGCTGGAGGTGGAGATAGCCAAGGAGAAGA       CCATTTGCACTAAGGATAAGGAAAGCGTGCTGCTGAACAAACGCGTGGCGGAGGAACAGCTGGTTGAA       TGCGTGAAAACCCGGGAGCTGCGGCACCAAGAGCGCCAGCTGGCCAAGGAGCAACTGCAAAAGGTGCA       AGCCCTCTGCCTGCCCCTGGACAAGGACAAGTTTGAGATGGACCTTCGTAACCTGTGGAGGGACTCCA       TTATCCCACGCAGCCTGGACAACCTGGGTTACAACCTCTACCATCCCCTGGGCTCGGAATTGGCCTCC       ATCCGCAGAGCCTGCGACCACATGCCCAGCCTCATGAGCTCCAAGGTGGAGGAGCTGGCCCGGAGCCT       CCGGGCGGATATCGAACGCGTGGCCCGCGAGAACTCAGACCTCCAACGCCAGAAGCTGGAAGCCCAGC       AGGGCCTGCGGGCCAGTCAGGAGGCGAAACAGAAGGTGGAGAAGGAGGCTCAGGCCCGGGAGGCCAAG       CTCCAAGCTGAATGCTCCCGGCAGACCCAGCTAGCGCTGGAGGAGAAGGCGGTGCTGCGGAAGGAACG       AGACAACCTGGCCAAGGAGCTGGAAGAGAAGAAGAGGGAGGCGGAGCAGCTCAGGATGGAGCTGGCCA       TCAGAAACTCAGCCCTGGACACCTGCATCAAGACCAAGTCGCAGCCGATGATGCCAGTGTCAAGGCCC       ATGGGCCCTGTCCCCAACCCCCAGCCCATCGACCCAGCTAGCCTGGAGGAGTTCAAGAGGAAGATCCT       GGAGTCCCAGAGGCCCCCTGCAGGCATCCCTGTAGCCCCATCCAGTGGCCTCGAGGCCACTGGATGGG       GCTACAGGGATGCCTCCGTGCTCCATGGCCAGACCCATGGATCC                                                 NOV27d, 214458688   SEQ ID NO: 624   468 aa   MW at 53321.6kD               Protein Sequence                     FALGSMGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLITLGLVLFMVYGNVHVSTESNLQAT           ERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQR       YMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVE       CVKTRELRHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELAS       IRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAK       LQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRP       MGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSGLEATGWGYPDASVLHGQTHGS                                             NOV27e, CG55193-01   SEQ ID NO: 625   1366 bp               DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 1327                       ATG GGTCTGGCCATGGAGCACGGAGGGTCCTACGCTCGGGCGGGGGGCAGCTCTCGGGGCTGCTGGTA           TTACCTGCGCTACTTCTTCCTCTTCGTCTCCCTCATCCAATTCCTCATCATCCTGGGGCTCGTGCTCT       TCATGGTCTATGGCAACGTGCACGTGAGCACAGAGTCCAACCTGCAGGCCACCGAGCGCCGAGCCGAG       GGCCTATACAGTCAGCTCCTAGGGCTCACGGCCTCCCAGTCCAACTTGACCAAGGAGCTCAACTTCAC       CACCCGCGCCAAGGATGCCATCATGCAGATGTGGCTGAATGCTCGCCGCGACCTGGACCGCATCAATG       CCAGCTTCCGCCAGTGCCAGGGTGACCGGGTAATCTACACGAACAATCAGAGGTACATGGCTGCCATC       ATCTTGAGTGAGAAGCAATGCAGAGATCAATTCAAGGACATGAACAAGAGCTGCGATGCCTTGCTCTT       CATGCTGAATCAGAAGGTGAAGACGCTGGAGGTGGAGATAGCCAAGGAGAAGACCATTTGCACTAAGG       ATAAGGAAAGCGTGCTGCTGAACAAACGCGTGGCGGAGGAACAGCTGGTTGAATGCGTGAAAACCCGG       GAGCTGCAGCACCAAGAGCGCCAGCTGGCCAAGGAGCAACTGCAAAAGGTGCAAGCCCTCTGCCTGCC       CCTGGACAAGGACAAGTTTGAGATGGACCTTCGTAACCTGTGGAGGGACTCCATTATCCCACGCAGCC       TGGACAACCTGGGTTACAACCTCTACCATCCCCTGGGCTCGGAATTGGCCTCCATCCGCAGAGCCTGC       GACCACATGCCCAGCCTCATGAGCTCCAAGGTGGAAGGTCAGTGCCGGAGCCTCCGGGCGGATATCGA       ACGCGTGGCCCGCGAGAACTCAGACCTCCAACGCCAGAAGCTGGAAGCCCAGCAGGGCCTGCGGGCCA       GTCAGGAGGCGAAACAGAAGGTGGAGAAGGAGGCTCAGGCCCGGGAGGCCAAGCTCCAAGCTGAATGC       TCCCGGCAGACCCAGCTAGCGCTGGAGGAGAAGGCGGTGCTGCGGAAGGAACGAGACAACCTGGCCAA       GGAGCTGGAAGAGAAGAAGAGGGAGGCGGAGCAGCTCAGGATGGAGCTGGCCATCAGAAACTCAGCCC       TGGACACCTGCATCAAGACCAAGTCGCAGCCGATGATGCCAGTGTCAAGGCCCATGGGCCCTGTCCCC       AACCCCCAGCCCATCGACCCAGCTAGCCTGGAGGAGTTCAAGAGGAAGATCCTGGAGTCCCAGAGGCC       CCCTGCAGGCATCCCTGTAGCCCCATCCAGTGGC TGA   GGAGGCTCCGGCACTGACCTAAGGGCGAATC           CCAGGA                                                   NOV27e, CG55193-01   SEQ ID NO: 626   442 aa   MW at 50568.7kD               Protein Sequence                     MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERPAE           GLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAI       ILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTR       ELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRAC       DHMPSLMSSKVEGQCRSLRADIERVARENSDLQRQKLEAQQGLHASQEAKQKVEKEAQAREAKLQAEC       SRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVP       NPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG                                             NOV27f, CG55193-02   SEQ ID NO: 627   1367 bp               DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 1327                       ATG GGTCTGGCCATGGAGCACGGAGGGTCCTACGCTCGGGCGGGGGGCAGCTCTCGGGGCTGCTGGTA           TTACCTGCGCTACTTCTTCCTCTTCGTCTCCCTCATCCAATTCCTCATCATCCTGGGGCTCGTGCTCT       TCATGGTCTATGGCAACGTGCACGTGAGCACAGAGTCCAACCTGCAGGCCACCGAGCGCCGAGCCGAG       GGCCTATACAGTCAGCTCCTAGGGCTCACGGCCTCCCAGTCCAACTTGACCAAGGAGCTCAACTTCAC       CACCCGCGCCAAGGATGCCATCATGCAGATGTGGCTGAATGCTCGCCGCGACCTGGACCGCATCAATG       CCAGCTTCCGCCAGTGCCAGGGTGACCGGGTAATCTACACGAACAATCAGAGGTACATGGCTGCCATC       ATCTTGAGTGAGAAGCAATGCAGAGATCAATTCAAGGACATGAACAAGAGCTGCGATGCCTTGCTCTT       CATGCTGAATCAGAAGGTGAAGACGCTGGAGGTGGAGATAGCCAAGGAGAAGACCATTTGCACTAAGG       ATAAGGAAAGCGTGCTGCTGAACAAACGCGTGGCGGAGGAACAGCTGGTTGAATGCGTGAAAACCCGG       GAGCTGCAGCACCAAGAGCGCCAGCTGGCCAAGGAGCAACTGCAAAAGGTGCAAGCCCTCTGCCTGCC       CCTGGACAAGGACAAGTTTGAGATGGACCTTCGTAACCTGTGGAGGGACTCCATTATCCCACGCAGCC       TGGACAACCTGGGTTACAACCTCTACCATCCCCTGGGCTCGGAATTGGCCTCCATCCGCAGAGCCTGC       GACCACATGCCCAGCCTCATGAGCTCCAAGGTGGAAGGTCAGTGCCGGAGCCTCCGGGCGGATATCGA       ACGCGTGGCCCGCGAGAACTCAGACCTCCAACGCCAGAAGCTGGAAGCCCAGCAGGGCCTGCGGGCCA       GTCAGGAGGCGAAACAGAAGGTGGAGAAGGAGGCTCAGGCCCGGGAGGCCAAGCTCCAAGCTGAATGC       TCCCGGCAGACCCAGCTAGCGCTGGAGGAGAAGGCGGTGCTGCGGAAGGAACGAGACAACCTGGCCAA       GGAGCTGGAAGAGAAGAAGAGGGAGGCGGAGCAGCTCAGGATGGAGCTGGCCATCAGAAACTCAGCCC       TGGACACCTGCATCAAGACCAAGTCGCAGCCGATGATGCCAGTGTCAAGGCCCATGGGCCCTGTCCCC       AACCCCCAGCCCATCGACCCAGCTAGCCTGGAGGAGTTCAAGAGGAAGATCCTGGAGTCCCAGAGGCC       CCCTGCAGGCATCCCTGTAGCCCCATCCAGTGGC TGA   GGAGGCTCCGGCACTGACCTAAGGGCGAATC           CCAGCAA                                                   NOV27f, CG55193-02   SEQ ID NO: 628   442 aa   MW at 50568.7kD               Protein Sequence                     MGLAMEHGGSYAPAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAE           GLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAI       ILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTR       ELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRAC       DHMPSLMSSKVEGQCRSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAEC       SRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVP       NPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG                                             NOV27g, CG55193-03   SEQ ID NO: 629   1367 bp               DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 1327                       ATG GGTCTGGCCATGGAGCACGGAGGGTCCTACGCTCGGGCGGGGGGCAGCTCTCGGGGCTGCTGGTA           TTACCTGCGCTACTTCTTCCTCTTCGTCTCCCTCATCCAATTCCTCATCATCCTGGGGCTCGTGCTCT       TCATGGTCTATGGCAACGTGCACGTGAGCACAGAGTCCAACCTGCAGGCCACCGAGCGCCGAGCCGAG       GGCCTATACAGTCAGCTCCTAGGGCTCACGGCCTCCCAGTCCAACTTGACCAAGGAGCTCAACTTCAC       CACCCGCGCCAAGGATGCCATCATGCAGATGTGGCTGAATGCTCGCCGCGACCTGGACCGCATCAATG       CCAGCTTCCGCCAGTGCCAGGGTGACCGGGTAATCTACACGAACAATCAGAGGTACATGGCTGCCATC       ATCTTGAGTGAGAAGCAATGCAGAGATCAATTCAAGGACATGAACAAGAGCTGCGATGCCTTGCTCTT       CATGCTGAATCAGAAGGTGAAGACGCTGGAGGTGGAGATAGCCAAGGAGAAGACCATTTGCACTAAGG       ATAAGGAAAGCGTGCTGCTGAACAAACGCGTGGCGGAGGAACAGCTGGTTGAATGCGTGAAAACCCGG       GAGCTGCAGCACCAAGAGCGCCAGCTGGCCAAGGAGCAACTGCAAAAGGTGCAAGCCCTCTGCCTGCC       CCTGGACAAGGACAAGTTTGAGATGGACCTTCGTAACCTGTGGAGGGACTCCATTATCCCACGCAGCC       TGGACAACCTGGGTTACAACCTCTACCATCCCCTGGGCTCGGAATTGGCCTCCATCCGCAGAGCCTGC       GACCACATGCCCAGCCTCATGAGCTCCAAGGTGGAAGGTCAGTGCCGGAGCCTCCGGGCGGATATCGA       ACGCGTGGCCCGCGAGAACTCAGACCTCCAACGCCAGAAGCTGGAAGCCCAGCAGGGCCTGCGGGCCA       GTCAGGAGGCGAAACAGAAGGTGGAGAAGGAGGCTCAGGCCCGGGAGGCCAAGCTCCAAGCTGAATGC       TCCCGGCAGACCCAGCTAGCGCTGGAGGAGAAGGCGGTGCTGCGGAAGGAACGAGACAACCTGGCCAA       GGAGCTGGAAGAGAAGAAGAGGGAGGCGGAGCAGCTCAGGATGGAGCTGGCCATCAGAAACTCAGCCC       TGGACACCTGCATCAAGACCAAGTCGCAGCCGATGATGCCAGTGTCAAGGCCCATGGGCCCTGTCCCC       AACCCCCAGCCCATCGACCCAGCTAGCCTGGAGGAGTTCAAGAGGAAGATCCTGGAGTCCCAGAGGCC       CCCTGCAGGCATCCCTGTAGCCCCATCCAGTGGC TGA   GGAGGCTCCGGCACTGACCTAAGGGCGAATC           CCAGCAA                                                   NOV27g, CG55193-03   SEQ ID NO: 630   442 aa   MW at 50568.7kD               Protein Sequence                     MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAE           GLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAI       ILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTR       ELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRAC       DHMPSLMSSKVEGQCRSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAEC       SRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVP       NPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG                                             NOV27h, CG55193-05   SEQ ID NO: 631   1188 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 1183                       GGATCC AACGTGCACGTGAGCACAGAGTCCAACCTGCAGGCCACCGAGCACCGAGCCGAGGGCCTATA           CAGTCAGCTCCTAGGGCTCACGGCCTCCCAGTCCAACTTGACCAAGGAGCTCAACTTCACCACCCGCG       CCAAGGATGCCATCATGCAGATGTGGCTGAATGCTCGCCGCGACCTGGACCGCATCAATGCCAGCTTC       CGCCAGTGCCAGGGTGACCGGGTCATCTACACGAACAATCAGAGGTACATGGCTGCCATCATCTTGAG       TGAGAAGCAATGCAGAGATCAATTCAAGGACATGAACAAGAGCTGCGATGCCTTGCTCTTCATGCTGA       ATCAGAAGGTGAAGACGCTGGAGGTGGAGATAGCCAAGGAGAAGACCATTTGCACTAAGGATAAGGAA       AGCGTGCTGCTGAACALACGCGTGGCGGAGGAACAGCTGGTTGAATGCGTGAAAACCCGGGAGCTGCA       GCACCAAGAGCGCCAGCTGGTCAAGGAGCAACTGCAAAAGGTGCAAGCCCTCTGCCTGCCCCTGGACA       AGGACAAGTTTGAGATGGACCTTCGTAACCTGTGGAGGGACTCCATTATCCCACGCAGCCTGGACAAC       CTGGGTTACAACCTCTACCATCCCCTGGGCTCGGAATTGGCCTCCATCCGCAGAGCCTGCGACCACAT       GCCCAGCCTCATGAGCTCCAAGGTGGAGGAGCTGGCCCGGAGCCTCCGGGCGGATATCGAACGCGTGG       TCCGCGAGAACTCAGACCTCCAACGCCAGAAGCTGGAAGCCCAGCAGGGCCTGCGGGCCAGTCAGGAG       GCGAAACAGAAGGTGGAGAAGGAGGCTCAGGCCCGGGAGGCCAAGCTCCAAGCTGAATGCTCCCGGCA       GACCCAGCTAGCGCTGGAGGAGAAGGCGGTGCTGCGGAGGGAACGAGACAACCTGGCCAAGGAGCTGG       AAGAGAAGAAGAGGGAGGCGGAGCAGCTCAGGATGGAGCTGGCCATCAGAAACTCAGCCCTGGACACC       TGCATCAAGACCAAGTCGCAGCCGATGATGCCAGTGTCAAGGCCCATGGGCCCTGTCCCCAACCCCCA       GCCCATCGACCCAGCTAGCCTGGAGGAGTTCAAGAGGAAGATCCTGGAGTCCCAGAGGCCCCCTGCAG       GCATCCCTGTAGCCCCATCCAGTGGCCTC GAG                                                   NOV27h, CG55193-05   SEQ ID NO: 632   392 aa   MW at 45001.1kD               Protein Sequence                     NVHVSTESNLQATEHRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQ           CQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESV       LLNKRVAEEQLVECVKTRELQHQERQLVKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLG       YNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVVRENSDLQRQKLEAQQGLRASQEAK       QKVEKEAQAREAKLQAECSRQTQLALEEKAVLRRERDNLAKELEEKKREAEQLRMELAIRNSALDTCI       KTKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG                                             NOV27i, CG55193-06   SEQ ID NO: 633   1188 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 1183                       GGATCC AACGTGCACGTGAGCACAGAGTCCAACCTGCAGGCCACCGAGCGCCGAGCCGAGGGCCTATA           CAGTCAGCTCCTAGGGCTCACGGCCTCCCAGTCCAACTTGACCAAGGAGCTCAACTTCACCACCCGCG       CCAAGGATGCCATCATGCAGATGTGGCTGAATGCTCGCCGCGACCTGGACCGCATCAATGCCAGCTTC       CGCCAGTGCCAGGGTGACCGGGTCATCTACACGAACAATCAGAGGTACATGGCTGCCATCATCTTGAG       TGAGAAGCAATGCAGAGATCAATTCAAGGACATGAACAAGAGCTGCGATGCCTTGCTCTTCATGCTGA       ATCAGAAGGTGAAGACGCTGGAGGTGGAGATAGCCAAGGAGAAGACCATTTGCACTAAGGATAAGGAA       AGCGTGCTGCTGAACAAACGCGTGGCGGAGGAACAGCTGGTTGAATGCGTGAAAACCCGGGAGCTGCA       GCACCAAGAGCGCCAGCTGGCCAAGGAGCAACTGCAAAAGGTGCAAGCCCTCTGCCTGCCCCTGGACA       AGGACAAGTTTGAGATGGACCTTCGTAACCTGTGGAGGGACTCCATTATCCCACGCAGCCTGGACAAC       CTGGGTTACAACCTCTACCATCCCCTGGGCTCGGAATTGGCCTCCATCCGCAGAGCCTGCGACCACAT       GCCCAGCCTCATGAGCTCCAAGGTGGAGGAGCTGGCCCGGAGCCTCCGGGCGGATATCGAACGCGTGG       CCCGCGAGAACTCAGACCTCCAACGCCAGAAGCTGGAAGCCCAGCAGGGCCTGCGGGCCAGTCAGGAG       GCGAAACAGAAGGTGGAGAAGGAGGCTCAGGCCCGGGAGGCCAAGCTCCAAGCTGAATGCTCCCGGCA       GACCCAGCTAGCGCTGGAGGAGAAGGCGGTGCTGCGGAAGGAACGAGACAACCTGGCCAAGGAGCTGG       AAGAGAAGAAGAGGGAGGCGGAGCAGCTCAGGATGGAGCTGGCCATCAGAAACTCAGCCCTGGACACC       TGCATCAAGACCAAGTCGCAGCCGATGATGCCAGTGTCAAGGCCCATGGGCCCTGTCCCCAACCCCCA       GCCCATCGACCCAGCTAGCCTGGAGGAGTTCAAGAGGAAGATCCTGGAGTCCCAGAGGCCCCCTGCAG       GCATCCCTGTAGCCCCATCCAGTGGCCTC GAG                                                   NOV27i, CG55193-06   SEQ ID NO: 634   392 aa   MW at 44936.0kD               Protein Sequence                     NVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTEAKDAIMQMWLNARRDLDRINASFRQ           CQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESV       LLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLG       YNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAK       QKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCI       KTKSQPMNPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG                                             NOV27j, CG55193-07   SEQ ID NO: 635   1410 bp               DNA Sequence   ORF Start: ATG at 79   ORF Stop: at 1405                       GAGATTCCCCCCCCTCGGGTCTCTTGGGCCTGTCCATGCGCCCCCCCCTCCGTGCTCCATGGCCAGAC               CCATGGATCC   ATG GGTCTGGCCATGGAGCACGGAGGGTCCTACGCTCGGGCGGGGGGCAGCTCTCGGG       GCTGCTGGTATTACCTGCGCTACTTCTTCCTCTTCGTCTCCCTCATCCAATTCCTCATCATCCTGGGG       CTCGTGCTCTTCATGGTCTATGGCAACGTGCACGTGAGCACAGAGTCCAACCTGCAGGCCACCGAGCG       CCGAGCCGAGGGCCTATACAGTCAGCTCCTAGGGCTCACGGCCTCCCAGTCCAACTTGACCAAGGAGC       TCAACTTCACCACCCGCGCCAAGGATGCCATCATGCAGATGTGGCTGAATGCTCGCcGCGACCTGGAC       CGCATCAATGCCAGCTTCCGCCAGTGCCAGGGTGACCGGGTCATCTACACGAACAATCAGAGGTACAT       GGCTGCCATCATCTTGAGTGAGAAGCAATGCAGAGATCAATTCAAGGACATGAACAAGAGCTGCGATG       CCTTGCTCTTCATGCTGAATCAGAAGGTGAAGACGCTGGAGGTGGAGATAGCCAAGGAGAAGACCATT       TGCACTAAGGATAAGGAAAGCGTGCTGCTGAACAAACGCGTGGCGGAGGAACAGCTGGTTGAATGCGT       GAAAACCCGGGAGCTGCAGCACCAAGAGCGCCAGCTGGCCAAGGAGCAACTGCAAAAGGTGCAAGCCC       TCTGCCTGCCCCTGGACAAGGACAAGTTTGAGATGGACCTTCGTAACCTGTGGAGGGACTCCATTATC       CCACGCAGCCTGGACAACCTGGGTTACAACCTCTACCATCCCCTGGGCTCGGAATTGGCCTCCATCCG       CAGAGCCTGCGACCACATGCCCAGCCTCATGAGCTCCAAGGTGGAGGAGCTGGCCCGGAGCCTCCGGG       CGGATATCGAACGCGTGGCCCGCGAGAACTCAGACCTCCAACGCCAGAAGCTGGAAGCCCAGCAGGGC       CTGCGGGCCAGTCAGGAGGCGAAACAGAAGGTGGAGAAGGAGGCTCAGGCCCGGGAGGCCAAGCTCCA       AGCTGAATGCTCCCGGCAGACCCAGCTAGCGCTGGAGGAGAAGGCGGTGCTGCGGAAGGAACGAGACA       ACCTGGCCAAGGAGCTGGAAGAGAAGAAGAGGGAGGCGGAGCAGCTCAGGATGGAGCTGGCCATCAGA       AACTCAGCCCTGGACACCTGCATCAAGACCAAGTCGCAGCCGATGATGCCAGTGTCAAGGCCCATGGG       CCCTGTCCCCAACCCCCAGCCCATCGACCCAGCTAGCCTGGAGGAGTTCAAGAGGAAGATCCTGGAGT       CCCAGAGGCCCCCTGCAGGCATCCCTGTAGCCCCATCCAGTGGCCTC GAG                                                   NOV27j, CG55193-07   SEQ ID NO: 636   442 aa   MW at 50593.7kD               Protein Sequence                     MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAE           GLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAI       ILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESvLLNKRvAEEQLVECVKTR       ELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRAC       DHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAEC       SRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVP       NPQPIDPASLEEFKRKTLESQRPPAGIPVAPSSG                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 27B.  
               TABLE 27B                       Comparison of the NOV27 protein sequences.                                        NOV27a --------------------------MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSL           NOV27b ------------------------------------------------------------       NOV27c EIPPPRVSWACPCAPPSVLHGQTHGSMGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSL       NOV27d ---------------------FALGSMGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSL       NOV27e --------------------------MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSL       NOV27f --------------------------MGLAMEHGGSYAHAGGSSRGCWYYLRYFFLFVSL       NOV27g --------------------------MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSL       NOV27h ------------------------------------------------------------       NOV27i ------------------------------------------------------------       NOV27j --------------------------MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSL               NOV27a IQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRA       NOV27b --------------GSNVHVSTESNLQATEHRAEGLYSQLLGLTASQSNLTKELNFTTRA       NOV27c IQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRA       NOV27d IQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRA       NOV27e IQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRA       NOV27f IQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRA       NOV27g IQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRA       NOV27h ----------------NVHVSTESNLQATEHRAEGLYSQLLGLTASQSNLTKELNFTTRA       NOV27i ----------------NVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRA       NOV27j IQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRA               NOV27a KDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSC       NOV27b KDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSC       NOV27c KDAIMQMWLNAREDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSC       NOV27d KDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSC       NOV27e KDAIMQMWLNARPDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSC       NOV27f KDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSC       NOV27g KDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSC       NOV27h KDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYNAAIILSEKQCRDQFKDMNKSC       NOV27i KDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSC       NOV27j KDAIMQMWLNARPDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSC               NOV27a DALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLA       NOV27b DALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLV       NOV27c DALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLA       NOV27d DALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELRHQERQLA       NOV27e DALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLA       NOV27f DALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLA       NOV27g DALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLA       NOV27h DALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLV       NOV27i DALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLA       NOV27j DALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLA               NOV27a KEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDH       NOV27b KEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDH       NOV27c KEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDH       NOV27d KEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDH       NOV27e KEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRPACDH       NOV27f KEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDH       NOV27g KEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRPACDH       NOV27h KEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRPACDH       NOV27i KEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRPACDH       NOV27j KEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDH               NOV27a MPSLMSSKVEGQCRSLRADIERVAPENSDLQRQKLEAQQGLEASQEAKQKVEKEAQAREA       NOV27b MPSLMSSKVEELARSLRADIERVVRENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREA       NOV27c MPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREA       NOV27d MPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLEASQEAKQKVEKEAQAREA       NOV27e MPSLMSSKVEGQCRSLRADIERVARENSDLQRQKLEAQQGLEASQEAKQKVEKEAQAREA       NOV27f MPSLMSSKVEGQCRSLRADIERVARENSDLQRQKLEAQQGLPASQEAKQKVEKEAQAREA       NOV27g MPSLMSSKVEGQCRSLRADIERVARENSDLQRQKLEAQQGLPASQEAKQKVEKEAQAREA       NOV27h MPSLMSSKVEELARSLHADIERVVRENSDLQRQKLEAQQGLEASQEAKQKVEKEAQAREA       NOV27i MPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREA       NOV27j MPSLMSSKVEELARSLEADIERVARENSDLQRQKLEAQQGLPASQEAKQKVEKEAQAREA               NOV27a KLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMETAIRNSALDTCIKTKS       NOV27b KLQAECSRQTQLALEEKAVLRRERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKS       NOV27c KLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKS       NOV27d KLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKS       NOV27e KLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLPMELAIRNSALDTCIKTKS       NOV27f KLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKS       NOV27g KLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRNELAIRNSALDTCIKTKS       NOV27h KLQAECSRQTQLALEEKAVLRRERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKS       NOV27i KLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKS       NOV27j KLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKS               NOV27a QPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG------------       NOV27b QPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSGLE----------       NOV27c QPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSGLE----------       NOV27d QPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSGLEATGWGYRDAS       NOV27e QPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG------------       NOV27f QPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG------------       NOV27g QPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG------------       NOV27h QPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG------------       NOV27i QPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG------------       NOV27j QPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG------------               NOV27a ---------       NOV27b ---------       NOV27c ---------       NOV27d VLHGQTHGS       NOV27e ---------       NOV27f ---------       NOV27g ---------       NOV27h ---------       NOV27i ---------       NOV27j ---------               NOV27a (SEQ ID NO: 618)       NOV27b (SEQ ID NO: 620)       NOV27c (SEQ ID NO: 622)       NOV27d (SEQ ID NO: 624)       NOV27e (SEQ ID NO: 626)       NOV27f (SEQ ID NO: 628)       NOV27g (SEQ ID NO: 630)       NOV27h (SEQ ID NO: 632)       NOV27i (SEQ ID NO: 634)       NOV27j (SEQ ID NO: 636)                  
 
      Further analysis of the NOV27a protein yielded the following properties shown in Table 27C.  
               TABLE 27C                       Protein Sequence Properties NOV27a                                        SignalP analysis:   Cleavage site between residues 51 and 52       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 6; pos. chg 0; neg. chg 1           H-region:   length 6; peak value 0.00           PSG score:   −4.40                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −1.10           possible cleavage site: between 50 and 51                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 29-25               −11.41                             PERIPHERAL   Likelihood = 7.85 (at 156)                         ALOM score: −11.41 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 36           Charge difference: −2.5 C(0.5)-N(3.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 2 (cytoplasmic tail 1 to 29)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   3   Hyd Moment(75):   5.06           Hyd Moment (95):   6.63   G content:   8           D/E content:   2   S/T content:   6                         Score: −6.39       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 36 LRY|FF                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: RKERDNLAKELEEKKRE at 355           content of basic residues: 15.6%           NLS Score: 0.02       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: 10, 22, 23, 26       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions       278 M   0.60       279 S   0.85       280 S   0.96       281 K   0.96       282 V   0.96       283 E   0.98       284 G   0.98       285 Q   0.99       286 C   0.99       287 R   0.99       288 S   0.99       289 L   0.99       290 R   0.99       291 A   0.99       292 D   0.99       293 I   0.99       294 E   0.99       295 R   0.99       296 V   0.99       297 A   0.99       298 R   0.99       299 E   0.99       300 N   0.99       301 S   0.99       302 D   1.00       303 L   1.00       304 Q   1.00       305 R   1.00       306 Q   1.00       307 K   1.00       308 L   1.00       309 E   1.00       310 A   1.00       311 Q   1.00       312 Q   1.00       313 G   1.00       314 L   1.00       315 R   1.00       316 A   1.00       317 S   1.00       318 Q   1.00       319 E   1.00       320 A   1.00       321 K   1.00       322 Q   1.00       323 K   1.00       324 V   1.00       325 E   1.00       326 K   1.00       327 E   1.00       328 A   1.00       329 Q   1.00       330 A   0.99       331 R   0.96       332 E   0.96       333 A   0.96       334 K   0.96       335 L   0.96       336 Q   0.96       337 A   0.87       338 E   0.72       339 C   0.71       340 S   0.75       341 R   0.92       342 Q   0.92       343 T   0.93       344 Q   0.99       345 L   1.00       346 A   1.00       347 L   1.00       348 E   1.00       349 E   1.00       350 K   1.00       351 A   1.00       352 V   1.00       353 L   1.00       354 R   1.00       355 K   1.00       356 E   1.00       357 R   1.00       358 D   1.00       359 N   1.00       360 L   1.00       361 A   1.00       362 K   1.00       363 E   1.00       364 L   1.00       365 E   1.00       366 E   1.00       367 K   1.00       368 K   1.00       369 R   1.00       370 E   1.00       371 A   1.00       372 E   1.00       373 Q   1.00       374 L   1.00       375 R   1.00       376 M   1.00       377 E   1.00       378 L   1.00       379 A   1.00       380 I   1.00       381 R   0.97       382 N   0.97       383 S   0.97       384 A   0.97       385 L   0.97       386 D   0.97       387 T   0.91       388 C   0.64       389 I   0.64       390 K   0.64           total: 113 residues                 Final Results (k = 9/23):                         39.1%: nuclear           26.1%: mitochondrial           17.4%: cytoplasmic            4.3%: extracellular, including cell wall            4.3%: Golgi            4.3%: plasma membrane            4.3%: peroxisomal                 &gt;&gt; prediction for CG55193-04 is nuc (k = 23)                  
 
      A search of the NOV27a protein against the Geneseq database, a proprietary se that contains sequences published in patents and patent publication, yielded homologous proteins shown in Table 27D.  
               TABLE 27D                          Geneseq Results for NOV27a                                         NOV27a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               ABG78367   Human protein, homologous to PV-1   1 . . . 442   442/442 (100%)    0.0           receptor, designated NOV7a -  Homo     1 . . . 442   442/442 (100%)              sapiens,  442 aa. [WO200226826-A2,           04-APR-2002]       AAE06600   Human protein having hydrophobic   1 . . . 442   439/442 (99%)   0.0           domain, HP10787 -  Homo sapiens , 442 aa.   1 . . . 442   439/442 (99%)           [WO200149728-A2, 12-JUL-2001]       AAM41619   Human polypeptide SEQ ID NO 6550 -   1 . . . 442   439/442 (99%)   0.0             Homo sapiens,  457 aa.   16 . . . 457    439/442 (99%)           [WO200153312-A1, 26-JUL-2001]       AAB42154   Human ORFX ORF1918 polypeptide sequence   1 . . . 442   439/442 (99%)   0.0           SEQ ID NO: 3836 -  Homo     38 . . . 479    439/442 (99%)             sapiens,  479 aa. [WO200058473-A2,           05-OCT-2000]       ABG78369   Human protein, homologous to PV-1   1 . . . 442   436/442 (98%)   0.0           receptor, designated NOV7c -  Homo     1 . . . 442   439/442 (98%)             sapiens,  442 aa. [WO200226826-A2,           04-APR-2002]                  
 
      In a BLAST search of public sequence databases, the NOV27a protein was found to have homology to the proteins shown in the BLASTP data in Table 27E.  
               TABLE 27E                          Public BLASTP Results for NOV27a                                         NOV27a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               AAH50365   PLVAP protein -  Homo sapiens     1 . . . 442   439/442 (99%)   0.0           (Human), 455 aa (fragment).   14 . . . 455    439/442 (99%)       Q9BX97   PV1 protein -  Homo sapiens     1 . . . 442   439/442 (99%)   0.0           (Human), 442 aa.   1 . . . 442   439/442 (99%)       Q8ND68   Hypothetical protein -  Homo sapiens     1 . . . 442   439/442 (99%)   0.0           (Human), 456 aa (fragment).   15 . . . 456    439/442 (99%)       Q9BZD5   Fenestrated-endothelial linked   1 . . . 442   438/442 (99%)   0.0           structure protein -  Homo sapiens     1 . . . 442   438/442 (99%)           (Human), 442 aa.       Q8N8Y0   Hypothetical protein FLJ38711 -   1 . . . 442   433/442 (97%)   0.0             Homo sapiens  (Human), 437 aa.   1 . . . 437   433/442 (97%)                  
 
      PFam analysis predicts that the NOV27a protein contains the domains shown in the Table 27F.  
               TABLE 27F                       Domain Analysis of NOV27a                                                        Pfam   NOV27a   Identities/   Expect           Domain   Match Region   Similarities   Value                   for the                   Matched Region                      
 
     Example 28  
      The NOV28 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 28A.  
               TABLE 28A                       NOV28 Sequence Analysis                                                NOV28a, CG55256-07   SEQ ID NO:637   4294 bp           DNA Sequence   ORF Start: ATG at 103   ORF Stop: TGA at 2818                       GCAGCGGCAACCCCGGCGCCGCGGCAAGGACTCGGAGGGCTGAGACGCGGCGGCGGCGGCGCGGGGAG               CGCGGGGCGCGGCGGCCGGAGCCCCGGGCCCGCC   ATG GGCCTCCCCGAGCCGGGCCCTCTCCGGCTTC       GATCCGCTGCTCGGCGGCCAAGGGCCGGCCAAGGAGTGCGAAAAGGACCAATTCCAGTGCCGGAACGA       GCGCTGCATCCCCTCTGTGTGGAGATGCGACGAGGACGATGACTGCTTAGACCACAGCGACGAGGACG       ACTGCCCCAAGAAGACCTGTGCAGACAGTGACTTCACCTGTGACAACGGCCACTGCATCCACGAACGG       TGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATGGCTCCGATGAGTCCGAGGCCACTTGCACACTGGG       CACCTGCCGTGGGGACGAGTTCCAGTGTGGGGATGGGACATGTGTCCTTGCAATCAAGCACTGCAACC       AGGAGCAGGACTGTCCAGATGGGAGTGATGAAGCTGGCTGCCTACAGGAGTCACCCTGTGAGGGTCCC       CGCAGATTTCAGTGTAAGAGTGGCAAGCGCGTGGACGGCGGGAAAGTGTGTGATGTGCAGAGGGACTG       CCGGGACTGGTCGGATGAGCTTCTGAAAGTGTGGTGCGGTGCCTGTCTACGCCCACTGGCTGGACTCA       GTCTCCTACCATCCCCCTCCTGGTATCTAGGCTCAAGGCCCTCCAGTGCCCCCTGCCCTGACACTTTC       TGCTCTGACCCTCTCTTTGGATTCATGTGCCGTCCTATGGCTTCACATGGGGCTTTTCGCCCCCAGGC       CTCTGGTCTACATCTCTACAAAGTGCTAAGAGCTTGTCCATCCCAGAGGAGGCTGAACGAGTGTCTGC       ACAACAATGGCGGCTGCTCACACATCTGCACTGACCTCAAGATTGGCTTTGAATGCACGTGCCCAGCA       GGCTTCCAGCTCCTGGACCAGAAGACCTGTGGCGACATTGATGAGTGCAAGGACCCAGATGCCTGCAG       CCAGATCTGTGTCAATTACAAGGGCTATTTTAAGTGTGAGTGCTACCCTGGCTACGAGATGGACCTAC       TGACCAAGAACTGCCAAGCTGCTGCTGGAAAGAGCCCATCCCTAATCTTCACCAACCGGTACGAGGTG       CGGAGGATCGACCTGGTGAAGCGGAACTATTCACGCCTCATCCCCATGCTCAAGAATGTCGTGGCACT       AGATGTGGAAGTTGCCACCAATCGCATCTACTGGTGTGACCTCTCCTACCGTAAGATCTATAGCGCCT       ACATGGACAAGGCCAGTGACCCGAAAGAGCAGGAGGTCCTCATTGACGAGCAGTTGCACTCTCCAGAG       GGCCTGGCAGTGGACTGGGTCCACAAGCACATCTACTGGACTGACTCGGGCAATAAGACCATCTCAGT       GGCCACAGTTGATGGTGGCCGCCGACGCACTCTCTTCAGCCGTAACCTCAGTGAACCCCGGGCCATCG       CTGTTGACCCCCTGCGAGGGTTCATGTATTGGTCTGACTGGGGGGACCAGGCCAAGATTGAGAAATCT       GGGCTCAACGGTGTGGACCGGCAAACACTGGTGTCAGACAATATTGAATGGCCCAACGGAATCACCCT       GGATCTGCTGAGCCAGCGCTTGTACTGGGTAGACTCCAAGCTACACCAACTGTCCAGCATTGACTTCA       GTGGAGGCAACAGAAAGACGCTGATCTCCTCCACTGACTTCCTGAGCCACCCTTTTGGGATAGCTGTG       TTTGAGGACAAGGTGTTCTGGACAGACCTGGAGAACGAGGCCATTTTCAGTGCAAATCGGCTCAATGG       CCTGGAAATCTCCATCCTGGCTGAGAACCTCAACAACCCACATGACATTGTCATCTTCCATGAGCTGA       AGCAGCCAAGAGCTCCAGATGCCTGTGAGCTGAGTGTCCAGCCTAATGGAGGCTGTGAATACCTGTGC       CTTCCTGCTCCTCAGATCTCCAGCCACTCTCCCAAGTACACATGTGCCTGTCCTGACACAATGTGGCT       GGGTCCAGACATGAAGAGGTGCTACCGAGCACCTCAATCTACCTCAACTACGACGTTAGCTTCTACCA       TGACGAGGACAGTACCTGCCACCACAAGAGCCCCCGGGACCACCGTCCACAGATCCACCTACCAGAAC       CACAGCACAGAGACACCAAGCCTGACAGCTGCAGTCCCAAGCTCAGTTAGTGTCCCCAGGGCTCCCAG       CATCAGCCCGTCTACCCTAAGCCCTGCAACCAGCAACCACTCCCAGCACTATGCAAATGAAGACAGTA       AGATGGGCTCAACAGTCACTGCCGCTGTTATCGGGATCATCGTGCCCATAGTGGTGATAGCCCTCCTG       TGCATGAGTGGATACCTGATCTGGAGAAACTGGAAGCGGAAGAACACCAAAAGCATGAATTTTGACAA       CCCAGTCTACAGGAAACAAACAGAAGAAGAAGATGAAGATGAGCTCCATATAGGGAGAACTGCTCAGA       TTGGCCATGTCTATCCTGCAGCAATCAGCAGCTTTGATCGCCCACTGTGGGCAGAGCCCTGTCTTGGG       GAGACCAGAGAACCGGAAGACCCAGCCCCTGCCCTCAAGGAGCTTTTTGTCTTGCCGGGGGAACCAAG       GTCACAGCTGCACCAACTCCCGAAGAACCCTCTTTCCGAGCTGCCTGTCGTCAAATCCAAGCGAGTGG       CATTAAGCCTTGAAGATGATGGACTACCC TGA   GGATGGGATCACCCCCTTCGTGCCTCATGGAATTCA           GTCCCATGCACTACACTCTGGATGGTGTATGACTGGATGAATGGGTTTCTATATATGGGTCTGTGTGA           GTGTATGTGTGTGTGTGATTTTTTTTTTAAATTTATGTTGCGGAAAGGTAACCACAAAGTTATGATGA           ACTGCAAACATGGAAAGGATGTGAGAGTTTTTCTATGTATAATGTTTTATACACTTTTTAACTGGTTG           CACTACCCATGAGGAATTCGTGGAATGGCTACTGCTGACTAACATGATGCACATAACCAAATGGGGGC           CAATGGCACAGTACCTTACTCATCATTTAAAAACTATATTTACAGAAGATGTTTGGTTGCTGGGGGGG           CTTTTTTGGGTTTTGGGGCATTTGTTTTTTGTAAATAAGATGATTATGCTTTGTGGCTATCCATCAAC           ATAAGTAAAAAAAAAAAAAAAACACTTCAACTCCCTCCCCCATTTAGATTATTTATTAACATATTTTA                   AAAATCAGATGAGTTCTATAAATAATTTAGAGAAGTGAGAGTATTTATTTTTGGCATGTTTGGCCCAC           CACACAGACTCTGTGTGTGTATGTGTGTGTTTATATGTGTATGTGTGTGACAGGAAAATCTGTAGAGA           AGAGGCACATCTATGGCTACTGTTCAAATACATAAAGATAAATTTATTTTCACACAGTCCACAAGGGC           TATATCTTGTAGTTTTCAGAAAAGCCTTTGGAAATCTGGATCAGGAAATAGATACCATGGTTTGTGCA           ATTATGTAGTAAAAAGGCAAATCTTTTCACCTCTGGCTATTCCTGAGACCCCAGGAAGTCAGGAAAAA           GCCTTTCAGCTCACCCATGGCTGCTGTGACTCCTACCAGGGCTTTCTTGGCTTTGGCGAAGGTCAGTG           TACAGACATTCCATGGTACCAGAGTGCTCAGAAAGTCAAGATAGGATATGCCTCACCCTCAGCTACTC           CTTGTTTTAAAGTTCAGCTCTTTGAGTAACTTCTTCAATTTCTTTCAGGACACTTGGGTTGAATTCAG           TAAGTTTCCTCTGAAGCACCCTGAAGGGTGCCATCCTTACAGAGCTAAGTGGAGACGTTTCCAGATCA           GCCCAAGTTTACTATAGAGACTGGCCCAGGCACTGAATGTCTAGGACATGCTGTGGATGAAGATAAAG           ATGGTGGAATAGGTTTTATCACATCTCTTATTTCTCTTTTCCCCTTACTCTCTACCATTTCCTTTATG           TGGGGAAACATTTTAAGGTAATAAATAGGTTACTTACCATCATATGTTCATATAGATGAAACTAATTT           TTGGCTTAAGTCAGAACAACTGGCCCCCAATTGAAGTCATATTTGTGGGGGGAAATGGCATACGCAAT           ATTATATTATATTGGATATTTATGTTCACACAGGAATTTGGTTTACTGCTTTGTAAATAAAAGGGAAA           ACTCCGGGTA                                                   NOV28a, CG55256-07   SEQ ID NO:638   905 aa   MW at 100461.4 kD               Protein Sequence                     MGLPEPGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKECEKDQFQCRNERCIPSVWRCDE           DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTLGTCRGDEFQCGD       GTCVLAIKHCNQEQDCPDGSDEAGCLQESPCEGPRRFQCKSGKRVDGGKVCDVQRDCRDWSDELLKVW       CGACLRPLAGLSLLPSPSWYLGSRPSSAPCPDTFCSDPLFGFMCRPMASHGAFRPQASGLHLYKVLRA       CPSQRRLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFK       CECYPGYEMDLLTKNCQAAACKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYW       CDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTL       FSRNLSEPPAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVD       SKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLN       NPHDIVIFHELKQPHAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP       QSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPEAPSISPSTLSPATS       INHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRAWKRATKSDAFDNPVYRKTTEEED       EDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPL       SELPVVKSKRVALSLEDDGLP                                     NOV28b, CG55256-10   SEQ ID NO:639   1079 bp           DNA Sequence   ORF Start: at 1   ORF Stop: TGA at 1009                     GCGGCTGATCCGCTGCTCGGCGGCCAAGGGCCGGCCAAGGATTGCGAAAAGGACCAATTCCAGTGCCG           GAACGAGCGCTGCATCCCCTCTGTGTGGAGATGCGACGAGGACGATGACTGCTTAGACCACAGCGACG       AGGACGACTGCCCCAAGAAGACCTGTGCAGACAGTGACTTCACCTGTGACAACGGCCACTGCATCCAC       GAACGGTGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATGGCTCCGATGAGTCCGAGGCCACTTGCAC       CAAGCAGGTGTGTCCTGCAGAGAAGCTGGGTCCAGACATGAAGAGGTGCTACCGAGCACCTCAATCTA       CCTCAACTACGACGTTAGCTTCTACCATGACGAGGACAGTACCTGCCACCACAAGAGCCCCCGGGACC       ACCGTCCACAGATCCACCTACCAGAACCACAGCACAGAGACACCAAGCCTGACAGCTGCAGTCCCAAG       CTCAGTTAGTGTCCCCAGGGCTCCCAGCATCAGCCCGTCTACCCTAAGCCCTGCAACCAGCAACCACT       CCCAGCACTATGCAAATGAAGACAGTAAGATGGGCTCAACAGTCACTGCCGCTGTTATCGGGATCATC       GTGCCCATAGTGGTGATAGCCCTCCTGTGCATGAGTGGATACCTGATCTGGAGAAACTGGAAGCGGAA       GAACACCAAAAGCATGAATTTTGACAACCCAGTCTACAGGAAAACAACAGAAGAAGAAGACGAAGATG       AGCTCCATATAGGGAGAACTGCTCAGATTGGCCATGTCTATCCTGCAGCAATCAGCAGCTTTGATCGC       CCACTGTGGGCAGAGCCCTGTCTTGGGGAGACCAGAGAACCGGAAGACCCAGCCCCTGCCCTCAAGGA       GCTTTTTGTCTTGCCGGGGGAACCAAGGTCACAGCTGCACCAACTCCCGAAGAACCCTCTTTCCGAGC       TGCCTGTCGTCAAATCCAAGCGAGTGGCATTAAGCCTTGAAGATGATGGACTACCC TGA   GGATGGGAT           CACCCCCTTCGTGCCTCATGGAATTCAGTCCCATGCACTACACTCTGGATGGTGTATGA                                                   NOV28b, CG55256-10   SEQ ID NO:640   336 aa   MW at 36894.7 kD               Protein Sequence                     AADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH           ERWKCDGEEECPDGSDESEATCTKQVCPAEKLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGT       VPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDR       PLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP                                     NOV28c, 272511714   SEQ ID NO:641   1983 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GGATCCGCGGCTGATCCGCTGCTCGGCGGCCAAGGGCCGGCCAAGGATTGCGAAAAGGACCAATTCCA           GTGCCGGAACGAGCGCTGCATCCCCTCTGTGTGGAGATGCGACGAGGACGATGACTGCTTAGACCACA       GCGACGAGGACGACTGCCCCAAGAAGACCTGTGCAGACAGTGACTTCACCTGTGACAACGGCCACTGC       ATCCACGAACGGTGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATGGCTCCGATGAGTCCGAGGCCAC       TTGCACCAAGCAGGTGTGTCCTGCAGAGAAGCTGAGCTGTGGACCCACCAGCCACAAGTGTGTACCTG       CCTCGTGGCGCTGCGACGGGGAGAAGGACTGCGAGGGTGGAGCGGATGAGGCCGGCTGTGCTACCTCA       CTGGGCACCTGCCGTGGGGACGAGTTCCAGTGTGGGGATGGGACATGTGTCCTTGCAATCAAGCACTG       CAACCAGGAGCAGGACTGTCCAGATGGGAGTGATGAAGCTGGCTGCCTACAGGGGCTGAACGAGTGTC       GCAGGCTTCCAGCTCCTGGACCAGAAGACCTGTGGCGACATTGATGAGTGCAAGGACCCAGATGCCTG       CAGCCAGATCTGTGTCAATTACAAGGGCTATTTTAAGTGTGAGTGCTACCCTGGCTACGAGATGGACC       TACTGACCAAGAACTGCAAGGCTGCTGCTGGCAAGAGCCCATCCCTAATCTTCACCAACCGGCACGAG       GTGCGGAGGATCGACCTGATGAAGCGGAACTATTCACGCCTCATCCCCATGCTCAAGAATGTCGTGGC       ACTAGATGTGGAAGTTGCCACCAATCGCATCTACTGGTGTGACCTCTCCTACCGTAAGATCTATAGCG       CCTACATGGACAAGGCCAGTGACCCGAAAGAGCAGGAGGTCCTCATTGACGAGCAGTTGCACTCTCCA       GAGGGCCTGGCAGTGGACTGGGTCCACAAGCACATCTACTGGACTGACTCGGGCAATAAGACCATCTC       AGTGGCCACAGTTGATGGTGGCCGCCGACGCACTCTCTTCAGCCGTAACCTCAGTGAACCCCGGGCCA       TCGCTGTTGACCCCCTGCGAGGGTTCATGTATTGGTCTGACTGGGGGGACCAGGCCAAGATTGAGAAA       TCTGGGCTCAACGGTGTGGACCGGCAAACACTGGTGTCAGACAATATTGAATGGCCCAACGGAATCAC       CCTGGATCTGCTGAGCCAGCGCTTGTACTGGGTAGACTCCAAGCTACACCAACTGTCCAGCATTGACT       TCAGTGGAGGCAACAGAAAGACGCTGATCTCCTCCACTGACTTCCTGAGCCACCCTTTTGGGATAGCT       GTGTTTGAGGACAAGGTGTTCTGGACAGACCTGGAGAACGAGGCCATTTTCAGTGCAAATCGGCTCAA       TGGCCTGGAAATCTCCATCCTGGCTGAGAACCTCAACAACCCACATGACATTGTCATCTTCCATGAGC       TGAAGCAGCCAAGAGCTCCAGATGCCTGTGAGCTGAGTGTCCAGCCTAATGGAGGCTGTGAATACCTG       TGCCTTCCTGCTCCTCAGATCTCCAGCCACTCTCCCAAGTACACATGTGCCTGTCCTGACACAATGTG       CCATGACGAGGACAGTACCTGCCACCACAAGAGCCCCCGGGACCACCGTCCACAGATCCACCTACCAG       AACCACAGCACAGAGACACCAAGCCTGACAGCTGCAGTCCCAAGCTCAGTTAGTGTCCCCAGGGTTCC       CAGCATCAGCCCGTCTACCCTAAGACCTGCAACCAGCAACCACTCCCAGCACTATGCAAATGAAGACA       GTAAGCTCGAG                                                 NOV28c, 272511714   SEQ ID NO:642   661 aa   MW at 73025.5 kD               Protein Sequence                     GSAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHC           IHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATS       LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICADLKIGFECTCP       AGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHE       VRRIDLMKHNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSP       EGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEK       SGLNGVDRQTLVSDNIEWPNGITLDLLSQPLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA       VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYL       CLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQ       NHSTETPSLTAAVPSSVSVPRVPSISPSTLRPATSNHSQHYANEDSKLE                                     NOV28d, CG55256-01   SEQ ID NO:643   2537 bp           DNA Sequence   ORF Start: ATG at 30   ORF Stop: TGA at 2505                       TGTTTTTTTTCTTCAGTACTTTAAATGTC   ATG CCACTCTCCTGGCCTGTAAGCTTTCCACAGAGAAGC           CTGCTGCCAGACCCATTGGAGCTTCTTTGTGTGTTATTTGTTTCTTTTTTCTTGCTGCTTTTACAGCT       CCAGCATCTTGCGGCGGCAGCGGCTGATCCGCTGCTCGGCGGCCAAGGGCCGGCCAAGGATTGCGAAA       AGGACCAATTCCAGTGCCGGAACGAGCGCTGCATCCCCTCTGTGTGGAGATGCGACGAGGACGATGAC       TGCTTAGACCACAGCGACGAGGACGACTGCCCTGCAGCCAAGAAGACACCTGTGAGAAGTGACTTCAC       CTGTGACAACGGCCACTGCATCCACGAACGGTGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATGGCT       CCGATGAGTCCGAGGCCACTTGCACCAAGCAGGTGTGTCCTGCAGAGAAGCTGAGCTGTGGACCCACT       AGCCACAAGTGTGTACCTGCCTCGTGGCGCTGCGACGGGGAGAAGGACTGCGAGGGTGGAGCGGATGA       GGCCGGCTGTGCTACCTCACTGGGCACCTGCCGTGGGGACGAGTTCCAGTGTGGGGATGGGACATGTG       TCCTTGCAATCAAGCACTGCAACCAGGAGCAGGACTGTCCAGATGGGAGTGATGAAGCTGGCTGCCTA       CAGGGGCTGAACGAGTGTCTGCACAACAATGGCGGCTGCTCACACATCTGCACTGACCTCAAGATTGG       CTTTGAATGCACGTGCCCAGCAGGCTTCCAGCTCCTGGACCAGAAGACCTGTGGCGCTGGCAAGAGCC       CATCCCTAATCTTCACCAACCGGCACGAGGTGCGGAGGATCGACCTGGTGAAGCGGAACTATTCACGC       CTCATCCCCATGCTCAAGAATGTCGTGGCACTAGATGTGGAAGTTGCCACCAATCGCATCTACTGGTG       TGACCTCTCCTACCGTAAGATCTATAGCGCCTACATGGACAAGGCCAGTGACCCGAAAGAGCAGGAGG       TCCTCATTGACGAGCAGTTGCACTCTCCAGAGGGCCTGGCAGTGGACTGGGTCCACAAGCACATCTAC       TGGACTGACTCGGGCAATAAGACCATCTCAGTGGCCACAGTTGATGGTGGCCGCCGACGCACTCTCTT       CAGCCGTAACCTCAGTGAACCCCGGGCCATCGCTGTTGACCCCCTGCGAGGGTTCATGTATTGGTCTG       ACTGGGGGGACCAGGCCAAGATTGAGAAATCTGGGCTCAACGGTGTGGACCGGCAAACACTGGTGTCA       GACAATATTGAATGGCCCAACGGAATCACCTTGGATCTGCTGAGCCAGCGCTTGTACTGGGTAGACTC       CAAGCTACACCAACTGTCCAGCATTGACTTCAGTGGAGGCAACAGAAAGACGCTGATCTCCTCCACTG       ACTTCCTGAGCCACCCTTTTGGGATAGCTGTGTTTGAGGACAAGGTGTTCTGGACAGACCTGGAGAAC       GAGGCCATTTTCAGTGCAAATCGGCTCAATGGCCTGGAAATCTCCATCCTGGCTGAGAACCTGAACAA       CCCACATGACATTGTCATCTTCCATGAGCTGAAGCAGCCAAGAGCTCCAGATGCCTGTGAGCTGAGTG       TCCAGCCTAATGGAGGCTGTGAATACCTGTGCCTTCCTGCTCCTCAGATCTCCAGCCACTCTCCCAAG       TACACATGTGCCTGTCCTGACACAATGTGGCTGGGTCCAGACATGAAGAGGTGCTACCGAGCACCTCA       ATCTACCTCAACTACGACGTTAGCTTCTACCATGACGAGGACAGTACCTGCCACCACAAGAGCCCCCG       GGACCACCGTCCACAGATCCACCTACCAGAACCACAGCACAGAGACACCAAGCCTGACAGCTGCAGTC       CCAAGCTCAGTTAGTGTCCCCAGGGCTCCCAGCATCAGCCCGTCTACCCTAAGCCCTGCAACCAGCAA       CCACTCCCAGCACGCAAATGAAGACAGTAAGATGGGCTCAACAGTCACTGCCGCTGTTATCGGGATCA       TCGTGCCCATAGCAAATGAAGACAGTAAGATGGGCTCAACAGTCACTGCCGCTGTTATCGGGATCATC       GTGCCCATAGGTGATAGCCCTCCTGTGCATGAGTGGATACCTGATCTGGAGAAACTGGAAGCGGAAGA       ACACCAAAAGCATGAATTTGACAACCCAGTCTACAGGAAAACAACAGAAGAAGAAGACGAAGATGAGC       TCCATATAGGGAGAACTGCTCAGATTGGCCATGTCTATCCTGCAGCAATCAGCAGCTTTGATCGCCCA       CTGTGGGCAGAGCCCTGTCTTGGGGAGACCAGAGAACCAGAAGACCCAGCCCCTGCCCTGAAGGAGCT       TTTTGTCTTGCCGGGGGAACCAAGGTCACAGCTGCACCAACTCCCGAAGAACCCTCTTTCCGAGCTGC       CTGTCGTCAAATCCAAGCAGCGAGTGGCATTAAGCCTTGAAGATGATGGACTACCC TGA   GGATGGGAT           CACCCCCTTCGTGCCTCATGG                                                           NOV28d, CG55256-01   SEQ ID NO:644   1825 aa   MW at 90830.8 kD               Protein Sequence                     MPLSWPVSFPQRSLLPDPLELLCVLFVSFFLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNER           CIPSVWRCDEDDDCLDHSDEDDCPAAKKTPVRSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK       QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADAGCATSLGTCRGDEFQCGDGTCVIAAIAACNQE       QDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGAGKSPSLIFTNRHE       VRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSP       EGLAVDWVHKHIYWTDSGNKTISVATVDGGRPRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEK       SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA       VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYL       CLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQ       NHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHANEDSKMGSTVTAAVIGIIVPIANEDSK       MGSTVTAAVIGIIVPIGDSPPVHEWIPDLEKLEAEEHQKHEFDNPVYRKTTEEEDEDELHIGRTAQIG       HVYPAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKQRVA       LSLEDDGLP                                     NOV28e, CG55256-02   SEQ ID NO:645   3039 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 3037                       ATG GGCCTCCCCGAGCCGGGCCCTCTCCGGCTTCTGGCGCTGCTGCTGCTGCTGCTGCTGCTGCTGCT           AGTGCGAAAAGGACCAATTCCAGTGCCGGAACGAGCGCTGCATCCCCTCTGTGTGGAGATGCGACGAG       GACGATGACTGCTTAGACCACAGCGACGAGGACGACTGCCCCAAGAAGACCTGTGCAGACAGTGACTT       CACCTGTGACAACGGCCACTGCATCCACGAACGGTGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATG       GCTCCGATGAGTCCGAGGCCACTTGCACCAAGCAGGTGTGTCCTGCAGAGAAGCTGAGCTGTGGACCC       ACCAGCCACAAGTGTGTACCTGCCTCGTGGCGCTGCGACGGGGAGAAGGACTGCGAGGGTGGAGCGGA       TGAGGCCGGCTGTGCTACCTTGTGCGCCCCGCACGAGTTCCAGTGCGGCAACCGCTCGTGCCTGGCCG       CCGTGTTCGTGTGCGACGGCGATGACGACTGTGGTGACGGCAGCGATGAGCGCGGCTGTGCAGACCCG       GCCTGCGGGCCCCGCGAGTTCCGCTGCGGCGGCGATGGCGGCGGCGCCTGCATCCCGGAGCGCTGGGT       CTGCGACCGCCAGTTTGACTGCGAGGACCGCTCGGACGAGGCAGCCGAGCTCTGCGGCCGCCCGGGCC       CCGGGGCCACGTCCGCGCCCGCCGCCTGCGCCACCGTCTCCCAGTTCGCCTGCCGCAGCGGCGAGTGC       ACTGGGCACCTGCCGTGGGGACGAGTTCCAGTGTGGGGATGGGACATGTGTCCTTGCAATCAAGCACT       GGTCCCCGCAGATTTCAGTGTAAGAGTGGCAAGCGCGTGGACGGCGGGAAAGTGTGTGATGTGCAGAG       GGACTGCCGGGACTGGTCGGATGAGCTTCTGAAAGTGTGGTGCGTCTCCTACCATCCCCCTCCTGGGC       TGAACGAGTGTCTGCACAACAATGGCGGCTGCTCACACATCTGCACTGACCTCAAGATTGGCTTTGAA       TGCACGTGCCCAGCAGGCTTCCAGCTCCTGGACCAGAAGACCTGTGGCGACATTGATGAGTGCAAGGA       CCCAGATGCCTGCAGCCAGATCTGTGTCAATTACAAGGGCTATTTTAAGTGTGAGTGCTACCCTGGCT       ACGAGATGGACCTACTGACCAAGAACTGCAAGGCTGCTGCTGGAAAGAGCCCATCCCTAATCTTCACC       AACCGGCACGAGGTGCGGAGGATCGACCTGGTGAAGCGGAACTATTCACGCCTCATCCCCATGCTCAA       GAATGTCGTGGCACTAGATGTGGAAGTTGCCACCAATCGCATCTACTGGTGTGACCTCTCCTACCGTA       AGATCTATAGCGCCTACATGGACAAGGCCAGTGACCCGAAAGAGCAGGAGGTCCTCATTGACGAGCAG       TTGCACTCTCCAGAGGGCCTGGCAGTGGACTGGGTCCACAAGCACATCTACTGGACTGACTCGGGCAA       TAAGACCATCTCAGTGGCCACAGTTGATGGTGGCCGCCGACGCACTCTCTTCAGCCGTAACCTCAGTG       AACCCCGGGCCATCGCTGTTGACCCCCTGCGAGGGTTCATGTATTGGTCTGACTGGGGGGACCAGGCC       AAGATTGAGAAATCTGGGCTCAACGGTGTGGACCGGCAAACACTGGTGTCAGACAATATTGAATGGCC       CAACGGAATCACCCTGGATCTGCTGAGCCAGCGCTTGTACTGGGTAGACTCCAAGCTACACCAACTGT       CCAGCATTGACTTCAGTGGAGGCAACAGAAAGACGCTGATCTCCTCCACTGACTTCCTGAGCCACCCT       TTTGGGATAGCTGTGTTTGAGGACAAGGTGTTCTGGACAGACCTGGAGAACGAGGCCATTTTCAGTGC       AAATCGGCTCAATGGCCTGGAAATCTCCATCCTGGCTGAGAACCTCAACAACCCACATGACATTGTCA       TCTTCCATGAGCTGAAGCAGCCAAGAGCTCCAGATGCCTGTGAGCTGAGTGTCCAGCCTAATGGAGGC       TGTGAATACCTGTGCCTTCCTGCTCCTCAGATCTCCAGCCACTCTCCCAAGTACACATGTGCCTGTCC       TGACACAATGTGGCTGGGTCCAGACATGAAGAGGTGCTACCGAGCACCTCAATCTACCTCAACTACGA       CGTTAGCTTCTACCATGACGAGGACAGTACCTGCCACCACAAGAGCCCCCGGGACCACCGTCCACAGA       TCCACCTACCAGAACCACAGCACAGAGACACCAAGCCTGACAGCTGCAGTCCCAAGCTCAGTTAGTGT       CAAATGAAGACAGTAAGATGGGCTCAACAGTCACTGCCGCTGTTATCGGGATCATCGTGCCCATAGTG       GTGATAGCCCTCCTGTGCATGAGTGGATACCTGATCTGGAGAAACTGGAAGCGGAAGAACACCAAAAG       CATGAATTTTGACAACCCAGTCTACAGGAAAACAACAGAAGAAGAAGATGAAGATGAGCTCCATATAG       GAGCCCTGTCTTGGGGAGACCAGAGAACCGGAAGACCCAGCCCCTGCCCTCAAGGAGCTTTTTGTCTT       GCCGGGGGAACCAAGGTCACAGCTGCACCAACTCCCGAAGAACCCTCTTTCCGAGCTGCCTGTCGTCA       AATCCAAGCGAGTGGCATTAAGCCTTGAAGATGATGGACTACCC TGA                                                   NOV28e, CG55256-02   SEQ ID NO:646   1012 aa   MW at 111334.6 kD               Protein Sequence                     MGLPEPGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKECEKDQFQCRNERCIPSVWRCDE           DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP       TSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADP       ACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATVSQFACRSGEC       VHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQESPCE       GPRRFQCKSGKRVDGGKVCDVQRDCRDWSDELLKVWCVSYHPPPGLNECLHNNGGCSHICTDLKIGFE       CTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFT       NRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQ       LHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPAAIAVDPLRGFMYWSDWGDQA       KIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP       FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGG       CEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHR       STYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIV       VIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWA       EPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP                                     NOV28f, CG55256-03   SEQ ID NO:647   2537 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 2086                       ATG GGCCTCCCCGAGCCGGGCCCTCTCCGGCTTCTGGCGCTGCTGCTGCTGCTGCTGCTGCTGCTGCT           GCTGCGGCTCCAGCATCTTGCGGCGGCAGCGGCTGATCCGCTGCTCGGCGGCCAAGGGCCGGCCAAGG       ATTGCGAAAAGGACCAATTCCAGTGCCGGAACGAGCGCTGCATCCCCTCTGTGTGGAGATGCGACGAG       GACGATGACTGCTTAGACCACAGCGACGAGGACGACTGCCCCAAGAAGACCTGTGCAGACAGTGACTT       CACCTGTGACAACGGCCACTGCATCCACGAACGGTGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATG       GCTCCGATGAGTCCGAGGCCACTTGCACCAAGCAGGTGTGTCCTGCAGAGAAGCTGAGCTGTGGACCC       ACCAGCCACAAGTGTGTACCTGCCTCGTGGCGCTGCGACGGGGAGAAGGACTGCGAGGGTGGAGCGGA       TGAGGCCGGCTGTGCTACCTCACTGGGCACCTGCCGTGGGGACGAGTTCCAGTGTGGGGATGGGACAT       GTGTCCTTGCAATCAAGCACTGCAACCAGGAGCAGGACTGTCCAGATGGGAGTGATGAAGCTGGCTGC       CTACAGGGGCTGAACGAGTGTCTGCACAACAATGGCGGCTGCTCACACATCTGCACTGACCTCAAGAT       AGTGCAAGGACCCAGATGOCTGCAGCCAGATCTGTGTCAATTACAAGGGCTATTTTAAGTGTGAGTGC       TACCCTGGCTACGAGATGGACCTACTGACCAAGAACTGCAAGGCTGCTGCTGGAAAGAGCCCATCCCT       AATCTTCACCAACCGGCACGAGGTGCGGAGGATCGACCTGGTGAAGCGGAACTATTCACGCCTCATCC       CCATGCTCAAGAATGTCGTGGCACTAGATGTGGAAGTTGCCACCAATCGCATCTACTGGTGTGACCTC       TCCTACCGTAAGATCTATAGCGCCTACATGGACAAGGCCAGTGACCCGAAAGAGCAGGAGGTCCTCAT       TGACGAGCAGTTGCACTCTCCAGAGGGCCTGGCAGTGGACTGGGTCCACAAGCACATCTACTGGACTG       ACTCGGGCAATAAGAACATCTCTGGTGGCCGCCGACGCACTCTCTTCAGCCGTAACCTCAGTGAACCC       CGGGCCATCGCTGTTGACCCCCTGCGAGGGTTCATGTATTGGTCTGACTGGGGGGACCAGGCCAAGAT       TGAGAAATCTGGGCTCAACGGTGTGGACCGGCAAACACTGGTGTCAGACAATATTGAATGGCCCAACG       GAATCACCCTGGATCTGCTGAGCCAGCGCTTGTACTGGGTAGACTCCAAGCTACACCAACTGTCCAGC       ATTGACTTCAGTGGAGGCAACAGAAAGACGCTGATCTCCTCCACTGACTTCCTGAGCCACCCTTTTGG       GATAGCTGTGTTTGAGGACAAGGTGTTCTGGACAGACCTGGAGAACGAGGCCATTTTCAGTGCAAATC       GGCTCAATGGCCTGGAAATCTCCATCCTGGCTGAGAACCTCAACAACCCACATGACATTGTCATCTTC       CATGAGCTGAAGCAGCCAAGAGCTCCAGATGCCTGTGAGCTGAGTGTCCAGCCTAATGGAGGCTGTGA       ATACCTGTGCCTTCCTGCTCCTCAGATCTCCAGCCACTCTCCCAAGTACACATGTGCCTGTCCTGACA       CAATGTGGCTGGGTCCAGACATGAAGAGGTGCTACCGAGATGCAAATGAAGACAGTAAGATGGGCTCA       ACAGTCACTGCCGCTGTTATCGGGATCATCGTGCCCATAGTGGTGATAGCCCTCCTGTGCATGAGTGG       ATACCTGATCTGGAGAAACTGGAAGCGGAAGAACACCAAAAGCATGAATTTTGACAACCCAGTCTACA       GGAAAACAACAGAAGAAGAAGATGAAGATGAGCTCCATATAGGGAGAACTGCTCAGATTGGCCATGTC       TATCCTGCACGAGTGGCATTAAGCCTTGAAGATGATGGACTACCC TGA   GGATGGGATCACCCCCTTCG           TGCCTCATGGAATTCAGTCCCATGCACTACACTCCGGATGGTGTATGACTGGATGAATGGGTTTCTAT           ATATGGGTCTGTGTGAGTGTATGTGTGTGTGTGATTTTTTTTTTTTAAATTATGTTGCGGAAAGGTAA           CCACAAAGTTATGATGAACTGCAAACATCCAAAGGATGTGAGAGTTTTTCTATGTATAATGTTTTATA           CACTTTTTAACTGGTTGCACTACCCATGAGGAATTCGTGGAATGGCTACTGCTGACTAACATGATGCA           CATAACCAAATGGGGGCCAATGGCACAGTACCTTACTCATCATTTAAAAACTATATTTACAGAAGATG           TTTGGTTGCTGGGGGGCTTTTTTAGGTTTTGGGCATTTGTTTTTTGTAAATAAGATGATTATGCTTTG           TGGCTATCCATCAACATAAGT                                                   NOV28f, CG55256-03   SEQ ID NO:648   695 aa   MW at 77399.4 kD               Protein Sequence                     MGLPEPGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDE           DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP       TSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC       LQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCEC       YPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDL       SYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKNISGGRRRTLFSRNLSEP       RAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSS       IDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF       HELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRDANEDSKMGS       TVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHV       YPARVALSLEDDGLP                                     NOV28g, CG55256-04   SEQ ID NO:649   2474 bp           DNA Sequence   ORF Start: ATG at 30   ORF Stop: TGA at 2442                       TGTTTTTTTTCTTCAGTACTTTAAATGTC   ATG CCACTCTCCTGGCCTGTAAGCTTTCCACAGAGAAGC           CTGCTGCCAGACCCATTGGAGCTTCTTTGTGTGTTATTTGTTTCTTTTTTCTTGCTGCTTTTACAGCT       CCAGCATCTTGCGGCGGCAGCGGCTGATCCGCTGCTCGGCGGCCAAGGGCCGGCCAAGGATTGCGAAA       AGGACCAATTCCAGTGCCGGAACGAGCGCTGCATCCCCTCTGTGTGGAGATGCGACGAGGACGATGAC       TGCTTAGACCACAGCGACGAGGACGACTGCCCTGCAGCCAAGAAGACACCTGTGAGAAGTGACTTCAC       CTGTGACAACGGCCACTGCATCCACGAACGGTGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATGGCT       CCGATGAGTCCGAGGCCACTTGCACCAAGCAGGTGTGTCCTGCAGAGAAGCTGAGCTGTGGACCCACT       AGCCACAAGTGTGTACCTGCCTCGTGGCGCTGCGACGGGGAGAAGGACTGCGAGGGTGGAGCGGATGA       TCCTTGCAATCAAGCACTGCAACCAGGAGCAGGACTGTCCAGATGGGAGTGATGAAGCTGGCTGCCTA       CTTTGAATGCACGTGCCCAGCAGGCTTCCAGCTCCTGGACCAGAAGACCTGTGGCGCTGGCAAGAGCC       CATCCCTAATCTTCACCAACCGGCACGAGGTGCGGAGGATCGACCTGGTGAAGCGGAACTATTCACGC       CTCATCCCCATGCTCAAGAATGTCGTGGCACTAGATGTGGAAGTTGCCACCAATCGCATCTACTGGTG       TGACCTCTCCTACCGTAAGATCTATAGCGCCTACATGGACAAGGCCAGTGACCCGAAAGAGCAGGAGG       TCCTCATTGACGAGCAGTTGCACTCTCCAGAGGGCCTGGCAGTGGACTGGGTCCACAAGCACATCTAC       TGGACTGACTCGGGCAATAAGACCATCTCAGTGGCCACAGTTGATGGTGGCCGCCGACGCACTCTCTT       CAGCCGTAACCTCAGTGAACCCCGGGCCATCGCTGTTGACCCCCTGCGAGGGTTCATGTATTGGTCTG       ACTGGGGGGACCAGGCCAAGATTGAGAAATCTGGGCTCAACGGTGTGGACCGGCAAACACTGGTGTCA       GACAATATTGAATGGCCCAACGGAATCACCTTGGATCTGCTGAGCCAGCGCTTGTACTGGGTAGACTC       CAAGCTACACCAACTGTCCAGCATTGACTTCAGTGGAGGCAACAGAAAGACGCTGATCTCCTCCACTG       ACTTCCTGAGCCACCCTTTTGGGATAGCTGTGTTTGAGGACAAGGTGTTCTGGACAGACCTGGAGAAC       GAGGCCATTTTCAGTGCAAATCGGCTCAATGGCCTGGAAATCTCCATCCTGGCTGAGAACCTGAACAA       CCCACATGACATTGTCATCTTCCATGAGCTGAAGCAGCCAAGAGCTCCAGATGCCTGTGAGCTGAGTG       TCCAGCCTAATGGAGGCTGTGAATACCTGTGCCTTCCTGCTCCTCAGATCTCCAGCCACTCTCCCAAG       TACACATGTGCCTGTCCTGACACAATGTGGCTGGGTCCAGACATGAAGAGGTGCTACCGAGCACCTCA       ATCTACCTCAACTACGACGTTAGCTTCTACCATGACGAGGACAGTACCTGCCACCACAAGAGCCCCCG       GGACCACCGTCCACAGATCCACCTACCAGAACCACAGCACAGAGACACCAAGCCTGACAGCTGCAGTC       CCAAGCTCAGTTAGTGTCCCCAGGGCTCCCAGCATCAGCCCGTCTACCCTAAGCCCTGCAACCAGCAA       CCACTCCCAGCACTATGCAAATGAAGACAGTAAGATGGGCTCAACAGTCACTGCCGCTGTTATCGGGA       TCATCGTGCCCATAGTGGTGATAGCCCTCCTGTGCATGAGTGGATACCTGATCTGGAGAAACTGGAAG       CGGAAGAACACCAAAAGCATGAATTTTGACAACCCAGTCTACAGGAAAACAACAGAAGAAGAAGACGA       AGATGAGCTCCATATAGGGAGAACTGCTCAGATTGGCCATGTCTATCCTGCAGCAATCAGCAGCTTTG       ATCGCCCACTGTGGGCAGAGCCCTGTCTTGGGGAGACCAGAGAACCGGAAGACCCAGCCCCTGCCCTC       AAGGAGCTTTTTGTCTTGCCGGGGGAACCAAGGTCACAGCTGCACCAACTCCCGAAGAACCCTCTTTC       CGAGCTGCCTGTCGTCAAATCCAAGCGAGTGGCATTAAGCCTTGAAGATGATGGACTACCC TGA   GGAT           GGGATCACCCCCTTCGTGCCTCATGG                                                   NOV28g, CG55256-04   SEQ ID NO:650   804 aa   MW at 88873.0 kD               Protein Sequence   1804                     MPLSWPVSFPQRSLLPDPLELLCVLFVSFFLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNER           CIPSVWRCDEDDDCLDHSDEDDCPAAKKTPVRSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK       QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQE       QDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGAGKSPSLIFTNRHE       VRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSP       EGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEK       SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA       VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYL       CLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTAAPGTTVHRSTYQ       NHSTETPSLTAAVPSSVSVPPAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIAL       LCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCL       GETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP                                     +TL,1NOV28h, CG55256-05   SEQ ID NO:651   4150 bp           DNA Sequence   ORF Start: ATG at 103   ORF Stop: TGA at 2674                       GCAGCGGCAACCCCGGCGCCGCGGCAAGGACTCGGAGGGCTGAGACGCGGCGGCGGCGGCGCGGGGAC               CGCGGGGCGCGGCGGCCGGAGCCCCGGGCCCGCC   ATG GGCCTCCCCGAGCCGGGCCCTCTCCGGCTTC       TGGCGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCGGCTCCAGCATCTTGCGGCGGCAGCGGCT       GATCCGCTGCTCGGCGGCCAAGGGCCGGCCAAGGAGTGCGAAAAGGACCAATTCCAGTGCCGGAACGA       GCGCTGCATCCCCTCTGTGTGGAGATGCGACGAGGACGATGACTGCTTAGACCACAGCGACGAGGACG       ACTGCCCCAAGAAGACCTGTGCAGACAGTGACTTCACCTGTGACAACGGCCACTGCATCCACGAACGG       TGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATGGCTCCGATGAGTCCGAGGCCACTTGCACACTGGG       CACCTGCCGTGGGGACGAGTTCCAGTGTGGGGATGGGACATGTGTCCTTGCAATCAAGCACTGCAACC       AGGAGCAGGACTGTCCAGATGGGAGTGATGAAGCTGGCTGCCTACAGGAGTCACCCTGTGAGGGTCCC       CGCAGATTTCAGTGTAAGAGTGGCAAGCGCGTGGACGGCGGGAAAGTGTGTGATGTGCAGAGGGACTG       CCGGGACTGGTCGGATGAGCTTCTGAAAGTGTGGTGCGGTGCCTGTCTACGCCCACTGGCTGGACTCA       GTCTCCTACCATCCCCCTCCTGGAGCCCATGTCCCTCCCCAGGGCTGAACGAGTGTCTGCACAACAAT       GGCGGCTGCTCACACATCTGCACTGACCTCAAGATTGGCTTTGAATGCACGTGCCCAGCAGGCTTCCA       GCTCCTGGACCAGAAGACCTGTGGCGACATTGATGAGTGCAAGGACCCAGATGCCTGCAGCCAGATCT       AACTGCAAGGCTGCTGCTGGCAAGAGCCCATCCCTAATCTTCACCAACCGGCACGAGGTGCGGAGGAT       CGACCTGGTGAAGCGGAACTATTCACGCCTCATCCCCATGCTCAAGAATGTCGTGGCACTAGATGTGG       AAGTTGCCACCAATCGCATCTACTGGTGTGACCTCTCCTACCGTAAGATCTATAGCGCCTACATGGAC       AGTGGACTGGGTCCACAAGCACATCTACTGGACTGACTCGGGCAATAAGACCATCTCAGTGGCCACAG       TTGATGGTGGCCGCCGACGCACTCTCTTCAGCCGTAACCTCAGTGAACCCCGGGCCATCGCTGTTGAC       CCCCTGCGAGGGTTCATGTATTGGTCTGACTGGGGGGACCAGGCCAAGATTGAGAAATCTGGGCTCAA       CGGTGTGGACCGGCAAACACTGGTGTCAGACAATATTGAATGGCCCAACGGAATCACCCTGGATCTGC       TGAGCCAGCGCTTGTACTGGGTAGACTCCAAGCTACACCAACTGTCCAGCATTGACTTCAGTGGAGGC       AACAGAAAGACGCTGATCTCCTCCACTGACTTCCTGAGCCACCCTTTTGGGATAGCTGTGTTTGAGGA       CAAGGTGTTCTGGACAGACCTGGAGAACGAGGCCATTTTCAGTGCAAATCGGCTCAATGGCCTGGAAA       AGAGCTCCAGATGCCTGTGAGCTGAGTGTCCAGCCTAATGGAGGCTGTGAATACCTGTGCCTTCCTGC       TCCTCAGATCTCCAGCCACTCTCCCAAGTACACATGTGCCTGTCCTGACACAATGTGGCTGGGTCCAG       ACATGAAGAGGTGCTACCGAGCACCTCAATCTACCTCAACTACGACGTTAGCTTCTACCATGACGAGG       ACAGTACCTGCCACCACAAGAGCCCCCGGGACCACCGTCCACAGATCCACCTACCAGAACCACAGCAC       AGAGACACCAAGCCTGACAGCTGCAGTCCCAAGCTCAGTTAGTGTCCCCAGGGCTCCCAGCATCAGCC       CGTCTACCCTAAGCCCTGCAACCAGCAACCACTCCCAGCACTATGCAAATGAAGACAGTAAGATGGGC       TCAACAGTCACTGCCGCTGTTATCGGGATCATCGTGCCCATAGTGGTGATAGCCCTCCTGTGCATGAG       TGGATACCTGATCTGGAGAAACTGGAAGCGGAAGAACACCAAAAGCATGAATTTTGACAACCCAGTCT       ACAGGAAAACAACAGAAGAAGAAGATGAAGATGAGCTCCATATAGGGAGAACTGCTCAGATTGGCCAT       GTCTATCCTGCAGCAATCAGCAGCTTTGATCGCCCACTGTGGGCAGAGCCCTGTCTTGGGGAGACCAG       AGAACCGGAAGACCCAGCCCCTGCCCTCAAGGAGCTTTTTGTCTTGCCGGGGGAACCAAGGTCACAGC       TGCACCAACTCCCGAAGAACCCTCTTTCCGAGCTGCCTGTCGTCAAATCCAAGCGAGTGGCATTAAGC       CTTGAAGATGATGGACTACCC TGA   GGATGGGATCACCCCCTTCGTGCCTCATGGAATTCAGTCCCATG           CACTACACTCTGGATGGTGTATGACTGGATGAATGGGTTTCTATATATGGGTCTGTGTGAGTGTATGT           GTGTGTGTGATTTTTTTTTTAAATTTATGTTGCGGAAAGGTAACCACAAAGTTATGATGAACTGCAAA           CATCCAAAGGATGTGAGAGTTTTTCTATGTATAATGTTTTATACACTTTTTAACTGGTTGCACTACCC           ATGAGGAATTCGTGGAATGGCTACTGCTGACTAACATGATGCACATAACCAAATGGGGGCCAATGGCA           CAGTACCTTACTCATCATTTAAAAACTATATTTACAGAAGATGTTTGGTTGCTGGGGGGGCTTTTTTG           GGTTTTGGGGCATTTGTTTTTTGTAAATAAGATGATTATGCTTTGTGGCTATCCATCAACATAAGTAA           AAAAAAAAAAAAAACACTTCAACTCCCTCCCCCATTTAGATTATTTATTAACATATTTTAAAAATCAG           ATGAGTTCTATAAATAATTTAGAGAAGTGAGAGTATTTATTTTTGGCATGTTTGGCCCACCACACAGA           CTCTGTGTGTGTATGTGTGTGTTTATATGTGTATGTGTGTGACAGGAAAATCTGTAGAGAAGAGGCAC                   ATCTATGGCTACTGTTCAAATACATAAAGATAAATTTATTTTCACACAGTCCACAAGGGGTATATCTT           GTAGTTTTCAGAAAAGCCTTTGGAAATCTGGATCAGGAAATAGATACCATGGTTTGTGCAATTATGTA           GTAAAAAAGGCAAATCTTTTCACCTCTGGCTATTCCTGAGACCCCAGGAAGTCAGGAAAAGCCTTTCA           GCTCACCCATGGCTGCTGTGACTCCTACCAGGGCTTTCTTGGCTTTGGCGAAGGTCAGTGTACAGACA           TTCCATGGTACCAGAGTGCTCAGAAAGTCAAGATAGGATATGCCTCACCCTCAGCTACTCCTTGTTTT           CTCTGAAGCACCCTGAAGGGTGCCATCCTTACAGAGCTAAGTGGAGACGTTTCCAGATCAGCCCAAGT           TTACTATAGAGACTGGCCCAGGCACTGAATGTCTAGGACATGCTGTGGATGAAGATAAAGATGGTGGA           ATAGGTTTTATCACATCTCTTATTTCTCTTTTCCCCTTACTCTCTACCATTTCCTTTATGTGGGGAAA           CATTTTAAGGTAATAAATAGGTTACTTACCATCATATGTTCATATAGATGAAACTAATTTTTGGCTTA           AGTCAGAACAACTGGCCCCCAATTGAAGTCATATTTGTGGGGGGAAATGGCATACGCAATATTATATT           ATATTGGATATTTATGTTCACACAGGAATTTGGTTTACTGCTTTGTAAATAAAAGGGAAAACTCCGGG           TA                                                   NOV28h, CG55256-05   SEQ ID NO:652   857 aa   MW at 95006.1 kD               Protein Sequence                             +TL,1MGLPEPGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKECEKDQFQCRNERCIPSVWRCDE               DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTLGTCRGDEFQCGD           GTCVLAIKHCNQEQDCPDGSDEAGCLQESPCEGPRRFQCKSGKRVDGGKVCDVQRDCRDWSDELLKVW           CGACLRPLAGLSLLPSPSWSPCPSPGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDID           ECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLI           PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT           DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDN           IEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEA           IFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT           SVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRK           NTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALKE           LFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP                                         NOV28i, CG55256-06   SEQ ID NO:653   4180 bp           DNA Sequence   ORF Start: ATG at 163   ORF Stop: TGA at 2704                   ATGGCCTCCCCGAACGTATGGGCCTCCCCGAGCGTATGGGCCTCCCCGAGCGTATGGGCCTCCCCGAG           CGTATGGGCCTCACCCGAGCGTATGGGCCTCCCCGAGCGTATGGGCCTCCCCGAGCGTATGGGCCTCC           CCGAGCGTATGGGCCTCCCCGAGCGT   ATG GGCCTCCCCGAGCCGGGCCCTCTCCGGCTTCTGGCGCTG       CTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCAGCTCCAGCATCTTGCGGCGGCAGCGGCTGATCCGCT       GCTCGGCGGCCAAGGGCCGGCCAAGGATTGCGAAAAGGACCAATTCCAGTGCCGGAACGAGCGCTGCA       TCCCCTCTGTGTGGAGATGCGACGAGGACGATGACTGCTTAGACCACAGCGACGAGGACGACTGCCCC       AAGAAGACCTGTGCAGACAGTGACTTCACCTGTGACAACGGCCACTGCATCCACGAACGGTGGAAGTG       TGACGGCGAGGAGGAGTGTCCTGATGGCTCCGATGAGTCCGAGGCCACTTGCACCAAGCAGGTGTGTC       CTGCAGAGAAGCTGAGCTGTGGACCCACCAGCCACAAGTGTGTACCTGCCTCGTGGCGCTGCGACGGG       GAGAAGGACTGCGAGGGTGGAGCGGATGAGGCCGGCTGTGCTACCTCACTGGGCACCTGCCGTGGGGA       CGAGTTCCAGTGTGGGGATGGGACATGTGTCCTTGCAATCAAGCACTGCAACCAGGAGCAGGACTGTC       AGGGGGCTGAACGAGTGTCTGCACAACAATGGCGGCTGCTCACACATCTGCACTGACCTCAAGATTGG       CTTTGAATGCACGTGCCCAGCAGGCTTCCAGCTCCTGGACCAGAAGACCTGTGGCGACATTGATGAGT       GCAAGGACCCAGATGCCTGCAGCCAGATCTGTGTCAATTACAAGGGCTATTTTAAGTGTGAGTGCTAC       CCTGGCTACGAGATGGACCTACTGACCAAGAACTGCAAGGCTGCTGCTGGAAAGAGCCCATCCCTAAT       CTTCACCAACCGGCACGAGGTGCGGAGGATCGACCTGGTGAAGCGGAACTATTCACGCCTCATCCCCA       TGCTCAAGAATGTCGTGGCACTAGATGTGGAAGTTGCCACCAATCGCATCTACTGGTGTGACCTCTCC       TACCGTAAGATCTATAGCGCCTACATGGACAAGGCCAGTGACCCGAAAGAGCAGGAGGTCCTCATTGA       CGAGCAGTTGCACTCTCCAGAGGGCCTGGCAGTGGACTGGGTCCACAAGCACATCTACTGGACTGACT       CGGGCAATAAGACCATCTCAGTGGCCACAGTTGATGGTGGCCGCCGACGCACTCTCTTCAGCCGTAAC       CTCAGTGAACCCCGGGCCATCGCTGTTGACCCCCTGCGAGGGTTCATGTATTGGTCTGACTGGGGGGA       CCAGGCCAAGATTGAGAAATCTGGGCTCAACGGTGTGGACCGGCAAACACTGGTGTCAGACAATATTG       AATGGCCCAACGGAATCACCCTGGATCTGCTGAGCCAGCGCTTGTACTGGGTAGACTCCAAGCTACAC       CAACTGTCCAGCATTGACTTCAGTGGAGGCAACAGAAAGACGCTGATCTCCTCCACTGACTTCCTGAG       CCACCCTTTTGGGATAGCTGTGTTTGAGGACAAGGTGTTCTGGACAGACCTGGAGAACGAGGCCATTT       TCAGTGCAAATCGGCTCAATGGCCTGGAAATCTCCATCCTGGCTGAGAACCTCAACAACCCACATGAC       ATTGTCATCTTCCATGAGCTGAAGCAGCCAAGAGCTCCAGATGCCTGTGAGCTGAGTGTCCAGCCTAA       TGGAGGCTGTGAATACCTGTGCCTTCCTGCTCCTCAGATCTCCAGCCACTCTCCCAAGTACACATGTG       CCTGTCCTGACACAATGTGGCTGGGTCCAGACATGAAGAGGTGCTACCGAGCACCTCAATCTACCTCA       ACTACGACGTTAGCTTCTACCATGACGAGGACAGTACCTGCCACCACAAGAGCCCCCGGGACCACCGT       CCACAGATCCACCTACCAGAACCACAGCACAGAGACACCAAGCCTGACAGCTGCAGTCCCAAGCTCAG       TTAGTGTCCCCAGGGCTCCCAGCATCAGCCCGTCTACCCTAAGCCCTGCAACCAGCAACCACTCCCAG       CACTATGCAAATGAAGACAGTAAGATGGGCTCAACAGTCACTGCCGCTGTTATCGGGATCATCGTGCC       CATAGTGGTGATAGCCCTCCTGTGCATGAGTGGATACCTGATCTGGAGAAACTGGAAGCGGAAGAACA       CCAAAAGCATGAATTTTGACAACCCAGTCTACAGGAAACAACAGAAGAAGAAGATGAAGATGAGCTC       CATATAGGGAGAACTGCTCAGATTGGCCATGTCTATCCTGCAGCAATCAGCAGCTTTGATCGCCCACT       GTGGGCAGAGCCCTGTCTTGGGGAGACCAGAGAACCGGAAGACCCAGCCCCTGCCCTCAAGGAGCTTT       TTGTCTTGCCGGGGGAACCAAGGTCACAGCTGCACCAACTCCCGAAGAACCCTCTTTCCGAGCTGCCT       GTCGTCAAATCCAAGCGAGTGGCATTAAGCCTTGAAGATGATGGACTACCC TGA   GGATGGGATCACCC           TTCTATATATGGGTCTGTGTGAGTGTATGTGTGTGTGTGATTTTTTTTTTAAATTTATGTTGCGGAAA           GGTAACCACAAAGTTATGATGAACTGCAAACATCCAAAGGATGTGAGAGTTTTTCTATGTATAATGTT           TTATACACTTTTTAACTGGTTGCACTACCCATGAGGAATTCGTGGAATGGCTACTGCTGACTAACATG           ATGCACATAACCAAATGGGGGCCAATGGCACAGTACCTTACTCATCATTTAAAAACTATATTTACAGA           AGATGTTTGGTTGCTGGGGGGGCTTTTTTGGGTTTTGGGGCATTTGTTTTTTGTAAATAAGATGATTA           TGCTTTGTGGCTATCCATCAACATAAGTAAAAAAAAAAAAAAAACACTTCAACTCCCTCCCCCATTTA           GATTATTTATTAACATATTTTAAAAATCAGATGAGTTCTATAAATAATTTAGAGAAGTGAGAGTATTT           ATTTTTGGCATGTTTGGCCCACCACACAGACTCTGTGTGTGTATGTGTGTGTTTATATGTGTATGTGT                   GTGACAGGAAAATCTGTAGAGAAGAGGCACATCTATGGCTACTGTTCAAATACATAAAGATAAATTTA           TTTTCACACAGTCCACAAGGGGTATATCTTGTAGTTTTCAGAAAAGCCTTTGGAAATCTGGATCAGGA           AATAGATACCATGGTTTGTGCAATTATGTAGTAAAAAAGGCAAATCTTTTCACCTCTGGCTATTCCTG           AGACCCCAGGAAGTCAGGAAAAGCCTTTCAGCTCACCCATGGCTGCTGTGACTCCTACCAGGGCTTTC           TTGGCTTTGGCGAAGGTCAGTGTACAGACATTCCATGGTACCAGAGTGCTCAGAAAGTCAAGATAGGA           AGGACACTTGGGTTGAATTCAGTAAGTTTCCTCTGAAGCACCCTGAAGGGTGCCATCCTTACAGAGCT           AAGTGGAGACGTTTCCAGATCAGCCCAAGTTTACTATAGAGACTGGCCCAGGCACTGAATGTCTAGGA           CATGCTGTGGATGAAGATAAAGATGGTGGAATAGGTTTTATCACATCTCTTATTTCTCTTTTCCCCTT           ACTCTCTACCATTTCCTTTATGTGGGGAAACATTTTAAGGTAATAAATAGGTTACTTACCATCATATC           TTCATATAGATGAAACTAATTTTTGGCTTAAGTCAGAACAACTGGCCCCCAATTGAAGTCATATTTGT           GGGGGGAAATGGCATACGCAATATTATATTATATTGGATATTTATGTTCACACAGGAATTTGGTTTAC                                                   NOV28i, CG55256-06   SEQ ID NO:654   847 aa   MW at 93663.5 kD               Protein Sequence                             +TL,1MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDE               DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP           TSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVIAIKHCNQEQDCPDGSDEAGC           LQVPPTFLGNRRRPRGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQ           ICVKGYFKCECYPGYEMDLLTKNGACKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALD           TVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLD           LLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGL           EISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLG           PDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPPAPSI           SPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNP           VYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRS           QLHQLPAPLSELPWKSKRVALSLEDDGLP                                         NOV28, CG55256-08   SEQ ID NO:655   2656 bp           DNA Sequence   ORF Start: ATG at 103   ORF Stop: TGA at 2428                       GCAGCGGCAACCCCGGCGCCGCGGCAAGGACTCGGAGGGCTGAGACGCGGCGGCGGCGGCGCGGGGAG               CGCGGGGCGCGGCGGCCGGAGCCCCGGGCCCGCC   ATG GGCCTCCCCGAGCCGGGCCCTCTCCGGCTTC       TGGCGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCGGCTCCAGCATCTTGCGGCGGCAGCGGCT       GATCCGCTGCTCGGCGGCCAAGGGCCGGCCAAGGAGTGCGAAAAGGACCAATTCCAGTGCCGGAACGA       GCGCTGCATCCCCTCTGTGTGGAGATGCGACGAGGACGATGACTGCTTAGACCACAGCGACGAGGACG       ACTGCCCCAAGAAGACCTGTGCAGACAGTGACTTCACCTGTGACAACGGCCACTGCATCCACGAACGG       TGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATGGCTCCGATGAGTCCGAGGCCACTTGCACCAAGCA       GGTGTGTCCTGCAGAGAAGCTGAGCTGTGGACCCACCAGCCACAAGTGTGTACCTGCCTCGTGGCGCT       GCGACGGGGAGAAGGACTGCGAGGGTGGAGCGGATGAGGCCGGCTGTGCTACCTCACTGGGCACCTGC       CGTGGGGACGAGTTCCAGTGTGGGGATGGGACATGTGTCCTTGCAATCAAGCACTGCAACCAGGAGCA       GGACTGTCCAGATGGGAGTGATGAAGCTGGCTGCCTACAGGGGCTGAACGAGTGTCTGCACAACAATG       GCGGCTGCTCACACATCTGCACTGACCTCAAGATTGGCTTTGAATGCACGTGCCCAGCAGGCTTCCAG       CTCCTGGACCAGAAGACCTGTGGCGACATTGATGAGTGCAAGGACCCAGATGCCTGCAGCCAGATCTG       TGTCAATTACAAGGGCTATTTTAAGTGTGAGTGCTACCCTGGCTACGAGATGGACCTACTGACCAAGA       ACTGCAAGGCTGCTGCTGGCAAGAGCCCATCCCTAATCTTCACCAACCGGCACGAGGTGCGGAGGATC       GACCTGGTGAAGCGGAACTATTCACGCCTCATCCCCATGCTCAAGAATGTCGTGGCACTAGATGTGGA       AGTTGCCACCAATCGCATCTACTGGTGTGACCTCTCCTACCGTAAGATCTATAGCGCCTACATGGACA       AGGCCAGTGACCCGAAAGAGCAGGAGGTCCTCATTGACGAGCAGTTGCACTCTCCAGAGGGCCTGGCA       GTGGACTGGGTCCACAAGCACATCTACTGGACTGACTCGGGCAATAAGACCATCTCAGTGGCCACAGT       TGATGGTGGCCGCCGACGCACTCTCTTCAGCCGTAACCTCAGTGAACCCCGGGCCATCGCTGTTGGCC       CCCTGCGAGGGTTCATGTATTGGTCTGACTGGGGGGACCAGGCCAAGATTGAGAAATCTGGGCTCAAC       GGTGTGGACCGGCAAACACTGGTGTTAGACAATATTGAATGGCCCAACGGAATCACCCTGGATCTGCT       GAGCCAGCGCTTGTACTGGGTAGACTCCAAGCTACACCAACTGTCCAGCATTGACTTCAGTGGAGGCA       ACAGAAAGACGCTGATCTCCTCCACTGACTTCCTGAGCCACCCTTTTGGGATAGCTGTGTTTGAGGAC       AAGGTGTTCTGGACAGACCTGGAGAACGAGGCCATTTTCAGTGCAAATCGGCTCAATGGCCTGGAAAT       CTCCATCCTGGCTGAGAACCTCAACAACCCACATGACATTGTCATCTTCCATGAGCTGAAGCAGCCAA       GAGCTCCAGATGCCTGTGAGCTGAGTGTCCAGCCTAATGGAGGCTGTGAATACCTGTGCCTTCCTGCT       CCTCAGATCTCCAGCCACTCTCCCAAGTACACATGTGCCTGTCCTGACACAATGTGGCTGGGCCCAGA       CATGAAGAGGTGCTACCGAGCACCTCAATCTACCTCAACTACGACGTTAGCTTCTACCATGACGAGGA       CAGTACCTGCCACCACAAGAGCCCCCGGGACCACCGTCCACAGATCCACCTACCAGAACCACAGCACA       GAGACACCAAGCCTGACAGCTGCAGTCCCAAGCTCAGTTAGTGTCCCCAGGGCTCCCAGCATCAGCCC       GTCTACCCTAAGCCCTGCAACCAGCAACCACTCCCAGCACTATGCAAATGAAGACAGTAAGATGGGCT       CAACAGTCACTGCCGCTGTTATCGGGATCATCGTGCCCATAGTGGTGATAGCCCTCCTGTGCATGAGT       GGATACCTGATCTGGAGAAACTGGAAGCGGAAGAACACCAAAAGCATGAATTTTGACAACCCAGTCTA       CAGGAAAACAACAGAAGAAGAAGACGAAGATGAGCTCCATATAGGGAGAACTGCTCAGATTGGCCATG       TCTATCCTGCACGAGTGGCATTAAGCCTTGAAGATGATGGACTACCC TGA   GGATGGGATCACCCCCTT           CGTGCCTCATGGAATTCAGTCCCATGCACTACACTCTGGAGGGTGTATGACTGGATGAATGGGTTTCT           ATATATGGGTCTGTGTGAGTGTATGTGTGTGTGTGATTTTTTTTTTAAATTTATGTTGCGGAAAGGTA           ACCACAAAGTTATGATGAACTGCAAACATCCAAAGGATGTGAGAGTTTTTCTATGTATAATGTTTTAT           ACAC                                                   NOV28, CG55256-08   SEQ ID NO:656   775 aa   MW at 85584.3 kD               Protein Sequence                             +TL,1MGLPEPGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKECEKDQFQCRNERCIPSVWRCDE               DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP           TSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC           LQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCEC           YPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDL           SYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSR           NLSEPRAIAVGPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVLDNIEWPNGITLDLLSQRLYWVDSKL           HQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPH           DIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYPAPQST           STTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHS           QHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSNNFDNPVYRKTTEEEDEDE           LHIGRTAQIGHVYPARVALSLEDDGLP                                         NOV28k, CG55256-09   SEQ ID NO:657   2623 bp           DNA Sequence   ORF Start: ATG at 103   ORF Stop: TGA at 2605                       GCAGCGGCAACCCCGGCGCCGCGGCAAGGACTCGGAGGGCTGAGACGCGGCGGCGGCGGCGCGGGGAG               CGCGGGGCGCGGCGGCCGGAGCCCCGGGCCCGCC   ATG GGCCTCCCCGAGCCGGGCCCTCTCCGGCTTC       TGGCGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCGGCTCCAGCATCTTGCGGCGGCAGCGGCT       GATCCGCTGCTCGGCGGCCAAGGGCCGGCCAAGGATTGCGAAAAGGACCAATTCCAGTGCCGGAACGA       GCGCTGCATCCCCTCTGTGTGGAGATGCGACGAGGACGATGACTGCTTAGACCACAGCGACGAGGACG       ACTGCCCCAAGAAGACCTGTGCAGACAGTGACTTCACCTGTGACAACGGCCACTGCATCCACGAACGG       TGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATGGCTCCGATGAGTCCGAGGCCACTTGCACCAAGCA       GGTGTGTCCTGCAGAGAAGCTGAGCTGTGGACCCACCAGCCACAAGTGTGTACCTGCCTCGTGGCGCT       GCGACGGGGAGAAGGACTGCGAGGGTGGAGCGGATGAGGCCGGCTGTGCTACCTCACTGGGCACCTGC       CGTGGGGACGAGTTCCAGTGTGGGGATGGGACATGTGTCCTTGCAATCAAGCACTGCAACCAGGAGCA       GGACTGTCCAGATGGGAGTGATGAAGCTGGCTGCCTACAGGGGCTGAACGAGTGTCTGCACAACAATG       GCGGCTGCTCACACATCTGCACTGACCTCAAGATTGGCTTTGAATGCACGTGCCCAGCAGGCTTCCAG       CTCCTGGACCAGAAGACCTGTGGCGACATTGATGAGTGCAAGGACCCAGATGCCTGCAGCCAGATCTG       TGTCMATTACAAGGGCTATTTTAAGTGTGAGTGCTACCCTGGCTACGAGATGGACCTACTGACCAAGA       ACTGCAAGGCTGCTGCTGGCAAGAGCCCATCCCTAATCTTCACCAACCGGCACGAGGTGCGGAGGATC       GACCTGGTGAAGCGGAACTATTCACGCCTCATCCCCATGCTCAAGAATGTCGTGGCACTAGATGTGGA       AGTTGCCACCAATCGCATCTACTGGTGTGACCTCTCCTACCGTAAGATCTATAGCGCCTACATGGACA       AGGCCAGTGACCCGAAAGAGCAGGAGGTCCTCATTGACGAGCAGTTGCACTCTCCAGAGGGCCTGGCA       GTGGACTGGGTCCACAAGCACATCTACTGGACTGACTCGGGCAATAAGACCATCTCAGTGGCCACAGT       TGATGGTGGCCGCCGACGCACTCTCTTCAGCCGTAACCTCAGTGAACCCCGGGCCATCGCTGTTGACC       CCCTGCGAGGGTTCATGTATTGGTCTGACTGGGGGGACCAGGCCAAGATTGAGAAATCTGGGCTCAAC       GGTGTGGACCGGCAAACACTGGTGTCAGACAATATTGAATGGCCCAACGGAATCACCCTGGATCTGCT       GAGCCAGCGCTTGTACTGGGTAGACTCCAAGCTACACCAACTGTCCAGCATTGACTTCAGTGGAGGCA       ACAGAAAGACGCTGATCTCCTCCACTGACTTCCTGAGCCACCCTTTTGGGATAGCTGTGTTTGAGGAC       CTCCATCCTGGCTGAGAACCTCAACAACCCACATGACATTGTCATCTTCCATGAGCTGAAGCAGCCAA       CCTCAGATCTCCAGCCACTCTCCCAAGTACACATGTGCCTGTCCTGACACAATGTGGCTGGGTCCAGA       CATGAAGAGGTGCTACCGAGCACCTCAATCTACCTCAACTACGACGTTAGCTTCTACCATGACGAGGA       CAGTACCTGCCACCACAAGAGCCCCCGGGACCACCGTCCACAGATCCACCTACCAGAACCACAGCACA       GAGACACCAAGCCTGACAGCTGCAGTCCCAAGCTCAGTTAGTGTCCCCAGGGCTCCCAGCATCAGCCC       GTCTACCCTAAGCCCTGCAACCAGCAACCACTCCCAGCACTATGCAAATGAAGACAGTAAGATGGGCT       CAACAGTCACTGCCGCTGTTATCGGGATCATCGTGCCCATAGTGGTGATAGCCCTCCTGTGCATGAGT       GGATACCTGATCTGGAGAAACTGGAAGCGGAAGAACACCAAAAGCATGAATTTTGCCAACCCAGTCTA       CAGGAAAACAACAGAAGAAGAAGACGAAGATGAGCTCCATATAGGGAGAACTGCTCAGATTGGCCATG       TCTATCCTGCAGCAATCAGCAGCTTTGATCGCCCACTGTGGGCAGAGCCCTGTCTTGGGGAGACCAGA       GAACCGGAAGACCCAGCCCCTGCCCTCAAGGAGCTTTTTGTCTTGCCGGGGGAACCAAGGTCACAGCT       GCACCAACTCCCGAAGAACCCTCTTTCCGAGCTGCCTGTCGTCAAATCCAAGCGAGTGGCATTAAGCC       TTGAAGATGATGGACTACCC TGA   GGATGGGATCACCCCC                                                   NOV28k, CG55256-09   SEQ ID NO:658   834 aa   MW at 92099.7 kD               Protein Sequence                     MGLPEPGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDE           DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP       TSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC       LQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCEC       YPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDL       SYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSR       NLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKL       HQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFATDLENEAIFSANRLNGLEISILAENLNNPH       DIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST       STTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHS       QHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFANPVYRKTTEEEDEDE       LHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSEL       PVVKSKRVALSLEDDGLP                                     NOV281, CG55256-11   SEQ ID NO:659   4607 bp           DNA Sequence   ORF Start: ATG at 237   ORF Stop: TGA at 3126                       GCTGGCGGCGGCCGCCCAGGGCCGGGGCCGCGCGCCCAGCCTGAGCCCGCCCCGCCGCCGAGCGTCAC               CGAACCTGCTTGAAATGCAGCCGAGGAGCCGGGGCGGGCGGCAGCGGCGGCGGCGGCGGCGGCGGGGG           CAGCGGCAACCCCGGCGCCGCGGCAAGGACTCGGAGGGCTGAGACGCGGCGGCGGCGGCGCGGGGAGC           GCGGGGCGCGGCGGCCGGAGCCCGGGCCCGCC   ATG GGCCTCCCCGAGCCGGGCCCTCTCCGGCTTCTG       GCGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCGGCTCCAGCATCTTGCGGCGGCAGCGGCTGA       TCCGCTGCTCGGCGGCCAAGGGCCGGCCAAGGAGTGCGAAAAGGACCAATTCCAGTGCCGGAACGAGC       GCTGCATCCCCTCTGTGTGGAGATGCGACGAGGACGATGACTGCTTAGACCACAGCGACGAGGACGAC       TGCCCCAAGAAGACCTGTGCAGACAGTGACTTCACCTGTGACAACGGCCACTGCATCCACGAACGGTG       GAAGTGTGACGGCGAGGAGGAGTGTCCTGATGGCTCCGATGAGTCCGAGGCCACTTGCACCAAGCAGG       TGTGTCCTGCAGAGAAGCTGAGCTGTGGACCCACCAGCCACAAGTGTGTACCTGCCTCGTGGCGCTGC       GACGGGGAGAAGGACTGCGAGGGTGGAGCGGATGAGGCCGGCTGTGCTACCTTGTGCGCCCCGCACGA       GTTCCAGTGCGGCAACCGCTCGTGCCTGGCCGCCGTGTTCGTGTGCGACGGCGATGACGACTGTGGTG       ACGGCAGCGATGAGCGCGGCTGTGCAGACCCGGCCTGCGGGCCCCGCGAGTTCCGCTGCGGCGGCGAT       GGCGGCGGCGCCTGCATCCCGGAGCGCTGGGTCTGCGACCGCCAGTTTGACTGCGAGGACCGCTCGGA       CGAGGCAGCCGAGCTCTGCGGCCGCCCGGGCCCCGGGGCCACGTCCGCGCCCGCCGCCTGCGCCACCG       TCTCCCAGTTCGCCTGCCGCAGCGGCGAGTGCGTGCACCTGGGCTGGCGCTGCGACGGCGACCGCGAC       TGCAAAGACAAATCGGACGAGGCCGACTGCCCACTGGGCACCTGCCGTGGGGACGAGTTCCAGTGTGG       GGATGGGACATGTGTCCTTGCAATCAAGCACTGCAACCAGGAGCAGGACTGTCCAGATGGGAGTGATG       AAGCTGGCTGCCTACAGGGGCTGAACGAGTGTCTGCACAACAATGGCGGCTGCTCACACATCTGCACT       GACCTCAAGATTGGCTTTGAATGCACGTGCCCAGCAGGCTTCCAGCTCCTGGACCAGAAGACCTGTGG       CGACATTGATGAGTGCAAGGACCCAGATGCCTGCAGCCAGATCTGTGTCAATTACAAGGGCTATTTTA       AGTGTGAGTGCTACCCTGGCTACGAGATGGACCTACTGACCAAGAACTGCAAGGCTGCTGGTGGAAAG       AGCCCATCCCTAATCTTCACCAACCGGTACGAGGTGCGGAGGATCGACCTGGTGAAGCGGAACTATTC       ACGCCTCATCCCCATGCTCAAGAATGTCGTGGCACTAGATGTGGAAGTTGCCACCAATCGCATCTACT       GGTGTGACCTCTCCTACCGTAAGATCTATAGCGCCTACATGGACAAGGCCAGTGACCcGAAAGAGcAG       GAGGTCCTCATTGACGAGCAGTTGCACTCTCCAGAGGGCCTGGCAGTGGACTGGGTCCACAAGCACAT       CTACTGGACTGACTCGGGCAATAAGACCATCTCAGTGGCCACAGTTGATGGTGGCCGCCGACGCACTC       TCTTCAGCCGTAACCTCAGTGAACCCCGGGCCATCGCTGTTGACCCCCTGCGAGGGTTCATGTATTGG       TCTGACTGGGGGGACCAGGCCAAGATTGAGAAATCTGGGCTCAACGGTGTGGACCGGCAAACACTGGT       GTCAGACAATATTGAATGGCCCAACGGAATCACCCTGGATCTGCTGAGCCAGCGCTTGTACTGGGTAG       ACTCCAAGCTACACCAACTGTCCAGCATTGACTTCAGTGGAGGCAACAGAAAGACGCTGATCTCCTCC       ACTGACTTCCTGAGCCACCCTTTTGGGATAGCTGTGTTTGAGGACAAGGTGTTCTGGACAGACCTGGA       GAACGAGGCCATTTTCAGTGCAAATCGGCTCAATGGCCTGGAAATCTCCATCCTGGCTGAGAACCTCA       ACAACCCACATGACATTGTCATCTTCCATGAGCTGAAGCAGCCAAGAGCTCCAGATGCCTGTGAGCTG       AGTGTCCAGCCTAATGGAGGCTGTGAATACCTGTGCCTTCCTGCTCCTCAGATCTCCAGCCACTCTCC       CAAGTACACATGTGCCTGTCCTGACACAATGTGGCTGGGTCCAGACATGAAGAGGTGCTACCGAGCAC       CTCAATCTACCTCAACTACGACGTTAGCTTCTACCATGACGAGGACAGTACCTGCCACCACAAGAGCC       CCCGGGACCACCGTCCACAGATCCACCTACCAGAACCACAGCACAGAGACACCAAGCCTGACAGCTGC       AGTCCCAAGCTCAGTTAGTGTCCCCAGGGCTCCCAGCATCAGCCCGTCTACCCTAAGCCCTGCAACCA       GGGATCATCGTGCCCATAGTGGTGATAGCCCTCCTGTGCATGAGTGGATACCTGATCTGGAGAAACTG       GAAGCGGAAGAACACCAAAAGCATGAATTTTGACAACCCAGTCTACAGGAAAACAACAGAAGAAGAAG       ATGAAGATGAGCTCCATATAGGGAGAACTGCTCAGATTGGCCATGTCTATCCTGCAGCAATCAGCAGC       TTTGATCGCCCACTGTGGGCAGAGCCCTGTCTTGGGGAGACCAGAGAACCGGAAGACCCAGCCCCTGC       CCTCAAGGAGCTTTTTGTCTTGCCGGGGGAACCAAGGTCACAGCTGCACCAACTCCCGAAGAACCCTC       TTTCCGAGCTGCCTGTCGTCAAATCCAAGCGAGTGGCATTAAGCCTTGAAGATGATGGACTACCC TGA           GGATGGGATCACCCCCTTCGTGCCTCATGGAATTCAGTCCCATGCACTACACTCTGGATGGTGTATGA           CTGGATGAATGGGTTTCTATATATGGGTCTGTGTGAGTGTATGTGTGTGTGTGATTTTTTTTTTAAAT           TTATGTTGCGGAAAGGTAACCACAAAGTTATGATGAACTGCAAACATCCAAAGGATGTGAGAGTTTTT                   CTATGTATAATGTTTTATACACTTTTTAACTGGTTGCACTACCCATGAGGAATTCGTGGAATGGCTAC           TGCTGACTAACATGATGCACATAACCAAATGGGGGCCAATGGCACAGTACCTTACTCATCATTTAAAA           ACTATATTTACAGAAGATGTTTGGTTGCTGGGGGGGCTTTTTTGGGTTTTGGGGCATTTGTTTTTTGT           AAATAAGATGATTATGCTTTGTGGCTATCCATCAACATAAGTAAAAAAAAAAAAAAAACACTTCAACT           CCCTCCCCCATTTAGATTATTTATTAACATATTTTAAAAATCAGATGAGTTCTATAAATAATTTAGAG           AAGTGAGAGTATTTATTTTTGGCATGTTTGGCCCACCACACAGACTCTGTGTGTGTATGTGTGTGTTT           ATATGTGTATGTGTGTGACAGGAAAATCTGTAGAGAAGAGGCACATCTATGGCTACTGTTCAAATACA           TAAAGATAAATTTATTTTCACACAGTCCACAAGGGGTATATCTTGTAGTTTTCAGAAAAGCCTTTGGA           AATCTGGATCAGGAAATAGATACCATGGTTTGTGCAATTATGTAGTAAAAAAGGCAAATCTTTTCACC           TCTGGCTATTCCTGAGACCCCAGGAAGTCAGGAAAAGCCTTTCAGCTCACCCATGGCTGCTGTGACTC           CTACCAGGGCTTTCTTGGCTTTGGCCAAGGTCAGTGTACAGACATTCCATGGTACCAGAGTGCTCAGA           AAGTCAAGATAGGATATGCCTGACCCTCAGCTACTCCTTGTTTTAAAGTTCAGCTCTTTGAGTAACTT           CTTCAATTTCTTTCAGGACACTTGGGTTGAATTCAGTAAGTTTCCTCTGAAGCACCCTGAAGGGTGCC           ATCCTTACAGAGCTAAGTGGAGACGTTTCCAGATCAGCCCAAGTTTACTATAGAGACTGGCCCAGGCA           CTGAATGTCTAGGACATGCTGTGGATGAAGATAAAGATGGTGGAATAGGTTTTATCACATCTCTTATT           TCTCTTTTCCCCTTACTCTCTACCATTTCCTTTATGTGGGGAAACATTTTAAGGTAATAAATAGGTTA           CTTACCATCATATGTTCATATAGATGAAACTAATTTTTGGCTTAAGTCAGAACAACTGGCCCCCAATT           GAAGTCATATTTGTGGGGGGAAATGGCATACGCAATATTATATTATATTGGATATTTATGTTCACACA           GGAATTTGGTTTACTGCTTTGTAAATAAAAGGGAAAACTCCGGGTATATGT                                                       NOV281, CG55256-11   SEQ ID NO:660   963 aa   MW at 105714.3 kD       I           Protein Sequence                     MGLPEPGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKECEKDQFQCRNERCIPSVWRCDE           DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP       TSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADP       ACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATVSQFACRSGEC       VHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNEC       LHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMD       LLTKNCKAAGGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYS       AYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRA       IAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID       FSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHE       LKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYPAPQSTSTTTLAS       TMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPAAPSISPSTLSPATSNHSQHYANED       SKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRWKRKNTKSMNFDNPVYR1CTTEEEDEDELHIGRTA       QIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKR       VALSLEDDGLP                                     NOV28m, SNP13382497 of   SEQ ID NO:661   4294 bp           CG55256-07,   ORF Start: ATG at 103   ORF Stop: TGA at 2818       DNA Sequence   SNP Pos: 2550   SNP Change: T to C                       GCAGCGGCAACCCCGGCGCCGCGGCAAGGACTCGGAGGGCTGAGACGCGGCGGCGGCGGCGCGGGGAG               CGCGGGGCGCGGCGGCCGGAGCCCCGGGCCCGCC   ATG GGCCTCCCCGAGCCGGGCCCTCTCCGGCTTC       TGGCGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCGGCTCCAGCATCTTGCGGCGGCAGCGGCT       ACTGCCCCAAGAAGACCTGTGCAGACAGTGACTTCACCTGTGACAACGGCCACTGCATCCACGAACGG       TGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATGGCTCCGATGAGTCCGAGGCCACTTGCACACTGGG       CACCTGCCGTGGGGACGAGTTCCAGTGTGGGGATGGGACATGTGTCCTTGCAATCAAGCACTGCAACC       AGGAGCAGGACTGTCCAGATGGGAGTGATGAAGCTGGCTGCCTACAGGAGTCACCCTGTGAGGGTCCC       CGCAGATTTCAGTGTAAGAGTGGCAAGCGCGTGGACGGCGGGAAAGTGTGTGATGTGCAGAGGGACTG       CCGGGACTGGTCGGATGAGCTTCTGAAAGTGTGGTGCGGTGCCTGTCTACGCCCACTGGCTGGACTCA       GTCTCCTACCATCCCCCTCCTGGTATCTAGGCTCAAGGCCCTCCAGTGCCCCCTGCCCTGACACTTTC       TGCTCTGACCCTCTCTTTGGATTCATGTGCCGTCCTATGGCTTCACATGGGGCTTTTCGCCCCCAGGC       CTCTGGTCTACATCTCTACAAAGTGCTAAGAGCTTGTCCATCCCAGAGGAGGCTGAACGAGTGTCTGC       ACAACAATGGCGGCTGCTCACACATCTGCACTGACCTCAAGATTGGCTTTGAATGCACGTGCCCAGCA       GGCTTCCAGCTCCTGGACCAGAAGACCTGTGGCGACATTGATGAGTGCAAGGACCCAGATGCCTGCAG       CCAGATCTGTGTCAATTACAAGGGCTATTTTAAGTGTGAGTGCTACCCTGGCTACGAGATGGACCTAC       TGACCAAGAACTGCCAAGCTGCTGCTGGAAAGAGCCCATCCCTAATCTTCACCAACCGGTACGAGGTG       CGGAGGATCGACCTGGTGAAGCGGAACTATTCACGCCTCATCCCCATGCTCAAGAATGTCGTGGCACT       ACATGGACAAGGCCAGTGACCCGAAAGAGCAGGAGGTCCTCATTGACGAGCAGTTGCACTCTCCAGAG       GGCCTGGCAGTGGACTGGGTCCACAAGCACATCTACTGGACTGACTCGGGCAATAAGACCATCTCAGT       GGGCTCAACGGTGTGGACCGGCAAACACTGGTGTCAGACAATATTGAATGGCCCAACGGAATCACCCT       GGATCTGCTGAGCCAGCGCTTGTACTGGGTAGACTCCAAGCTACACCAACTGTCCAGCATTGACTTCA       GTGGAGGCAACAGAAAGACGCTGATCTCCTCCACTGACTTCCTGAGCCACCCTTTTGGGATAGCTGTG       TTTGAGGACAAGGTGTTCTGGACAGACCTGGAGAACGAGGCCATTTTCAGTGCAAATCGGCTCAATGG       CCTGGAAATCTCCATCCTGGCTGAGAACCTCAACAACCCACATGACATTGTCATCTTCCATGAGCTGA       AGCAGCCAAGACCTCCAGATGCCTGTGAGCTGAGTGTCCAGCCTAATGGAGGCTGTGAATACCTGTGC       CTTCCTGCTCCTCAGATCTCCAGCCACTCTCCCAAGTACACATGTGCCTGTCCTGACACAATGTGGCT       GGGTCCAGACATGAAGAGGTGCTACCGAGCACCTCAATCTACCTCAACTACGACGTTAGCTTCTACCA       TGACGAGGACAGTACCTGCCACCACAAGAGCCCCCGGGACCACCGTCCACAGATCCACCTACCAGAAC       CACAGCACAGAGACACCAAGCCTGACAGCTGCAGTCCCAAGCTCAGTTAGTGTCCCCAGGGCTCCCAG       CATCAGCCCGTCTACCCTAAGCCCTGCAACCAGCAACCACTCCCAGCACTATGCAAATGAAGACAGTA       AGATGGGCTCAACAGTCACTGCCGCTGTTATCGGGATCATCGTGCCCATAGTGGTGATAGCCCTCCTG       TGCATGAGTGGATACCTGATCTGGAGAAACTGGAAGCGGAAGAACACCAAAAGCATGAATTTTGACAA       CCCAGTCTACAGGAAAACAACAGAAGAAGAAGA   C   GAAGATGAGCTCCATATAGGGAGAACTGCTCAGA       TTGGCCATGTCTATCCTGCAGCAATCAGCAGCTTTGATCGCCCACTGTGGGCAGAGCCCTGTCTTGGG       GAGACCAGAGAACCGGAAGACCCAGCCCCTGCCCTCAAGGAGCTTTTTGTCTTGCCGGGGGAACCAAG       GTCACAGCTGCACCAACTCCCGAAGAACCCTCTTTCCGAGCTGCCTGTCGTCAAATCCAAGCGAGTGG       CATTAAGCCTTGAAGATGATGGACTACCC TGA   GGATGGGATCACCCCCTTCGTGCCTCATGGAATTCA           GTCCCATGCACTACACTCTGGATGGTGTATGACTGGATGAATGGGTTTCTATATATGGGTCTGTGTGA           GTGTATGTGTGTGTGTGATTTTTTTTTTAAATTTATGTTGCGGAAAGGTAACCACAAAGTTATGATGA           ACTGCAAACATCCAAAGGATGTGAGAGTTTTTCTATGTATAATGTTTTATACACTTTTTAACTGGTTG           CACTACCCATGAGGAATTCGTGGAATGGCTACTGCTGACTAACATGATGCACATAACCAAATGGGGGC           CAATGGCACAGTACCTTACTCATCATTTAAAAACTATATTTACAGAAGATGTTTGGTTGCTGGGGGGG           CTTTTTTGGGTTTTGGGGCATTTGTTTTTTGTAAATAAGATGATTATGCTTTGTGGCTATCCATCAAC           ATAAGTAAAAAAAAAAAAAAAACACTTCAACTCCCTCCCCCATTTAGATTATTTATTAACATATTTTA                   AAAATCAGATGAGTTCTATAAATAATTTAGAGAAGTGAGAGTATTTATTTTTGGCATGTTTGGCCCAC           CACACAGACTCTGTGTGTGTATGTGTGTGTTTATATGTGTATGTGTGTGACAGGAAAATCTGTAGAGA           AGAGGCACATCTATGGCTACTGTTCAAATACATAAAGATAAATTTATTTTCACACAGTCCACAAGGGG           TATATCTTGTAGTTTTCAGAAAAGCCTTTGGAAATCTGGATCAGGAAATAGATACCATGGTTTGTGCA           ATTATGTAGTAAAAAAGGCAAATCTTTTCACCTCTGGCTATTCCTGAGACCCCAGGAAGTCAGGAAAA           GCCTTTCAGCTCACCCATGGCTGCTGTGACTCCTACCAGGGCTTTCTTGGCTTTGGCGAAGGTCAGTG           TACAGACATTCCATGGTACCAGAGTGCTCAGAAAGTCAAGATAGGATATGCCTCACCCTCAGCTACTC           CTTGTTTTAAAGTTCAGCTCTTTGAGTAACTTCTTCAATTTCTTTCAGGACACTTGGGTTGAATTCAG           TAAGTTTCCTCTGAAGCACCCTGAAGGGTGCCAATCCTTACAGAGCTAAGTAAGACGTTTCCAGATCA           GCCCAAGTTTACTATAGAGACTGGCCCAGGCACTGAATGTCTAGGACATGCTGTGGATGAAGATAAAG           ATGGTGGAATAGGTTTTATCACATCTCTTATTTCTCTTTTCCCCTTACTCTCTACCATTTCCTTTATG           TGGGGAAACATTTTAAGGTAATAAATAGGTTACTTACCATCATATGTTCATATAGATGAAACTAATTT           TTGGCTTAAGTCAGAACAACTGGCCCCCAATTGAAGTCATATTTGTGGGGGGAAATGGCATACGCAAT           ATTATATTATATTGGATATTTATGTTCACACAGGAATTTGGTTTACTGCTTTGTAAATAAAAGGGAAA           ACTCCGGGTA                                                   NOV28m, SNP13382497 of   SEQ ID NO:662   905 aa   MW at 100461.4 kD               CG55256-07, Protein   SNP Pos: 816       SNP Change: Asp to Asp           Sequence                     MGLPEPGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKECEKDQFQCRNERCIPSVWRCDE           DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTLGTCRGDEFQCGD       GTCVNAIKHCNQEQDCPDGSDEAGCLQESPCEGPRRFQCKSGKRVDGGKVCDVQRDCRDWSDELLKVW       CGACLRPLAGLSLLPSPSWYLGSRPSSAPCPDTFCSDPLFGFMCRPMASHGAFRPQASGLHLYKVLRA       CPSQRRLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFK       CECYPGYEMDLLTKNCQAAAGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYW       CDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTL       FSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVD       SKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLN       NPHDIVIFHELKQPAAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP       QSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATS       NHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEED       EDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPL       SELPVVKSKRVALSLEDDGLP                                     NOV28n, SNP13382498 of   SEQ ID NO:663   4294 bp           CG55256-07,   ORF Start: ATG at 103   ORF Stop: TGA at 2818       DNA Sequence   SNP Pos: 2783   SNP Change: G to A                       GCAGCGGCAACCCCGGCGCCGCGGCAAGGACTCGGAGGGCTGAGACGAGGCGGCGGCGGCGCGGGGAG               CGCGGGGCGCGGCGGCCGGAGCCCCGGGCCCGCC ATG GGCCTCCCCGAGCCGGGCCCTCTCCGGCTTC         TGGCGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCGGCTCCAGCATGTTGCGGCGGCAGCGGCT       GATCCGCTGCTCGGCGGCCAAGGGCCGGCCAAGGAGTGCGAAAAGGACCAATTCCAGTGCCGGAACGA       GCGCTGCATCCCCTCTGTGTGGAGATGCGACGAGGACGATGACTGCTTAGACCACACAGACGAGGACG       ACTGCCCCAAGAAGACCTGTGCAGACAGTGACTTCACCTGTGACAACGGCCACTGCATCCACGAACGG       TGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATGGCTCCGATGAGTCCGAGGCCACTTGCACACTGGG       CACCTGCCGTGGGGACGAGTTCCAGTGTGGGGATGGGACATGTGTCCTTGCATCAAAGCACTGCAACC       AGGAGCAGGACTGTCCAGATGGGAGTGATGAAGCTGGCTGCCTACAGGAGTCACCCTGTGAGGGTCCC       CGCAGATTTCAGTGTAAGAGTGGCAAGCGCGTGGACGGCGGGAAAGTGTGTGATGTGCAGAGGGACTG       CCGGGACTGGTCGGATGAGCTTCTGAAAGTGTGGTGCGGTGCCTGTCTACGCCCACTGGCTGGACTCA       GTCTCCTACCATCCCCCTCCTGGTATCTAGGCTCAAGGCCCTCCAGTGCCCCCTGCCCTGACACTTTC       TGCTCTGACCCTCTCTTTGGATTCATGTGCCGTCCTATGGCTTCACATGGGGCTTTTCGCCCCCAGGC       CTCTGGTCTACATCTCTACAAAGTGCTAAGAGCTTGTCCATCCCAGAGGAGGCTGAACGAGTGTCTGC       ACAACAATGGCGGCTGCTCACACATCTGCACTGACCTCAAGATTGGCTTTGAATGCACGTGCCCAGCA       GGCTTCCAGCTCCTGGACCAGAAGACCTGTGGCGACATTGATGAGTGCAAGGACCCAGATGCCTGCAG       CCAGATCTGTGTCAATTACAAGGGCTATTTTAAGTGTGAGTGCTACCCTGGCAACGAGATGGACCTAC       TGACCAAGAACTGCCAAGCTGCTGCTGGAAAGAGCCCATCCCTAATCTTCACCAACCGGTACGAGGTG       CGGAGGATCGACCTGGTGAAGCGGAACTATTCACGCCTCATCCCCATGCTCAAGAATGTCGTGGCACT       AGATGTGGAAGTTGCCACCAATCGCATCTACTGGTGTGACCTCTCCTACCGTAAGATCTATAGCGCCT       ACATGGACAAGGCCAGTGACCCGAAAGAGCAGGAGGTCCTCATTGACGAGCAGTTGCACTCTCCAGAG       GGCCTGGCAGTGGACTGGGTCCACAAGCACATGTACTGGACTGACTCGGGCAATAAGACCATCTCAGT       GGCCACAGTTGATGGTGGCCGCCGACGCACTCTCTTCAGCCGTAACCTCAGTGAACCCCGGGCCATCG       CTGTTGACCCCCTGCGAGGGTTCATGTATTGGTCTGACTGGGGGGACCAGGCCAAGATTGAGAAATCT       GGGCTCAACGGTGTGGACCGGCAAACACTGGTGTCAGACAATATTGAATGGCCCAACGGAATCACCCT       GGATCTGCTGAGCCAGCGCTTGTACTGGGTAGACTCCAAGCTACACCAACTGTCCAGCATTGACTTCA       GTGGAGGCAACAGAAAGACGCTGATCTCCTCCACTGACTTCCTGAGCCACCCTTTTGGGATAGCTGTG       TTTGAGGACAAGGTGTTCTGGACAGACCTGGAGAACGAGGCCATTTTCAGTGCAAATCGGCTCAATGG       CCTGGAAATCTCCATCCTGGCTGAGAACCTCAACAACCCACATGACATTGTCATCTTCCATGAGCTGA       AGCAGCCAAGAGCTGGAGATGCCTGTGAGCTGAGTGTCCAGCCTAATGGAGGCTGTGAATACCTGTGC       CTTCCTGCTCCTCAGATCTCCAGCCACTCTCCCAAGTACACATGTGCCTGTCCTGACACAATGTGGCT       GGGTCCAGACATGAAGAGGTGCTACCGAGCACCTCAATCTACCTCAACTACGACGTTAGCTTCTACCA       TGACGAGGACAGTACCTGCCACCACAAGAGCCCCCGGGACCACCGTCCACAGATGGACCTACCAGAAC       CACAGCACAGAGACACCAAGCCTGACAGCTGCAGTCCCAAGCTCAGTTAGTGTCCCCAGGGCTCCCAG       CATCAGCCCGTCTACCCTAAGCCCTGCAACCAGCAACCACTCCCAGCACTATGCAAATGAGAACAGTA       AGATGGGCTCAACAGTCACTGCCGCTGTTATCGGGATCATCGTGCCCATAGTGGTGATAGCCCTCCTG       TGCATGAGTGGATACCTGATCTGGAGAAACTGGAAGCGGAAGAACACCAAAAGCATGAATTTTGACAA       CCCAGTCTACAGGAAAACAACAGAAGAAGAAGATGAAGATGAGCTCCATATAGGGAGAACTGCTCAGA       TTGGCCATGTCTATCCTGCAGCAATGAGCAGCTTTGATCGCCCACTGTGGGCAGAGCCCTGTCTTGGG       GAGACCAGAGAACCGGAAGACCCAGCCCCTGCCCTCAAGGAGCTTTTTGTCTTGCCGGGGGAACCAAG       GTCACAGCTGCACCAACTCCCGAAGAACCCTCTTTCCGAGCTGCCTGTCGTCAAATCCAAGC   A   AGTGG       CATTAAGCCTTGAAGATGATGGACTACCC TGA   GGATGGGATCACCCCCTTCGTGCCTCATGGAATTCA           GTCCCATGCACTACACTCTGGATGGTGTATGACTGGATGAATGGGTTTCTATATATGGGTCTGTGTGA           GTGTATGTGTGTGTGTGATTTTTTTTTTAAATTTATGTTGCGGAAAGGTAACCACAAAGTTATGATGA           ACTGCAAACATCCAAAGGATGTGAGAGTTTTTCTATGTATAATGTTTTATACACTTTTTAACTGGTTG           CACTACCCATGAGGAATTCGTGGAATGGCTACTGCTGACTAACATGATGCACATAACCAAATGGGGGC           CAATGGCACAGTACCTTACTCATCATTTAAAAACTATATTTACAGAGATGTTTGGTTGCTGGGGGGGG           CTTTTTTGGGTTTTGGGGCATTTGTTTTTTGTAAATAAGATGATTATGCTTTGTGGCTATCCATCAAC           ATAAGTAAAAAAAAAAAAAAAACACTTCAACTCCCTCCCCCATTTAGATTATTTATTAACATATTTTA                   AAAATCAGATGAGTTCTATAAATAATTTAGAGAAGTGAGAGTATTTATTTTTGGCATGTTTGGCCCAC           CACACAGACTCTGTGTGTGTATGTGTGTGTTTATATGTGTATGTGTGTGACAGGAAAATCTGTAGAGA           AGAGGCACATCTATGGCTACTGTTCAAATACATAAAGATAAATTTATTTTCACACAGTCCACAAGGGG           TATATCTTGTAGTTTTCAGAAAAGCCTTTGGAAATCTGGATCAGGAAATAGATACCATGGTTTGTGCA           ATTATGTAGTAAAAAAGGCAAATCTTTTCACCTCTGGCTATTCCTGAGACCCCAGGAAGTCAGGAAAA           GCCTTTCAGCTCACCCATGGCTGCTGTGACTCCTACCAGGGCTTTCTTGGCTTTGGCGAAGGTCAGTG           TACAGACATTCCATGGTACCAGAGTGCTCAGAAAGTCAAGATAGGATATGCCTCACCCTCAGCTACTC           CTTGTTTTAAAGTTCAGCTCTTTGAGTAACTTCTTCAATTTCTTTCAGGACACTTGGGTTGAATTCAG           TAAGTTTCCTCTGAAGCACCCTGAAGGGTGCCATCCTTACAGAGCTAAGTGGAGACGTTTCCAGATCA           GCCCAAGTTTACTATAGAGACTGGCCCAGGCACTGATGTCTAGGACATGCTGTGGATGAAGGATAAAG           ATGGTGGAATAGGTTTTATCACATCTCTTATTTCTCTTTTCCCCTTACTCTCTACCATTTCCTTTATG           TGGGGAAACATTTTAAGGTAATAAATAGGTTACTTACCATCATATGTTCATATAGATGAAACTAATTT           TTGGCTTAAGTCAGAACAACTGGCCCCCAATTGAAGTCATATTTGTGGGGGGAAATGGCATACGCAAT           ATTATATTATATTGGATATTTATGTTCACACAGGAATTTGGTTTACTGCTTTGTAAATAAAAGGGAAA           ACTCCGGGTA                                                   NOV28n, SNP13382498 of   SEQ ID NO:664   905 aa   MW at 100433.3 kD               CG55256-07,   SNP Pos: 894   SNP Change: Arg to Gln           Protein Sequence                     MGLPEPGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKECEKDQFQCRNERCIPSVWRCDE           DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTLGTCRGDEFQCGD       GTCVLAIKHCNQEQDCPDGSDEAGCLQESPCEGPRRFQCKSGKRVDGGKVCDVQRDCRDWSDELLKVW       CGACLRPLAGLSLLPSPSWYLGSRPSSAPCPDTFCSDPLFGFMCRPMASHGAFRPQASGLHLYKVLRA       CPSQRRLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFK       CECYPGYEMDLLTKNCQAAAGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYW       CDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTL       FSRNLSEPAAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVD       SKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLN       NPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP       QSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATS       NHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEED       EDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPL       SELPVVKSKQVALSLEDDGLP                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 28B.  
               TABLE 28B                       Comparison of the NOV28 protein sequences.                                                NOV28a   ----------MGLPEPGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKECEKD   (SEQ ID NO:638)                   NOV28b   ------------------------------------------AADPLLGGQGPAKDCEKD   (SEQ ID NO:640)               NOV28c   ----------------------------------------GSAADPLLGGQGPAKDCEKD   (SEQ ID NO:642)               NOV28d   MPLSWPVSFPQRSLLPDPLELLCVLFVSFFLLLLQLQHLAAAAADPLLGGQGPAKDCEKD   (SEQ ID NO:644)               NOV28e   ------MGLPE----PGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKECEKD   (SEQ ID NO:646)               NOV28f   ------MGLPE----PGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKDCEKD   (SEQ ID NO:648)               NOV28g   MPLSWPVSFPQRSLLPDPLELLCVLFVSFFLLLLQLQHLAAAAADPLLGGQGPAKDCEKD   (SEQ ID NO:650)               NOV28h   ----------MGLPEPGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKECEKD   (SEQ ID NO:652)               NOV28i   ------MGLPE----PGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKD   (SEQ ID NO:654)               NOV28   ------MGLPE----PGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKECEKD   (SEQ ID NO:656)               NOV28k   ------MGLPE----PGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKDCEKD   (SEQ ID NO:658)               NOV281   ------MGLPE----PGPLRLLALLLLLLLLLLLRLQHLAAAAADPLLGGQGPAKECEKD   (SEQ ID NO:660)               NOV28a   QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIHERWKCDGE               NOV28b   QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIHERWKCDGE               NOV28c   QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIHERWKCDGE               NOV28d   QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPAAKKTPVRSDFTCDNGHCIHERWKCDGE               NOV28e   QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCVRSDFTCDNGHCIHERWKCDGE               NOV28f   QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCVRSDFTCDNGHCIHERWKCDGE               NOV28g   QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPAAKKTPVRSDFTCDNGHCIHERWKCDGE               NOV28h   QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCVRSDFTCDNGHCIHERWKCDGE               NOV28i   QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIHERWKCDGE               NOV28   QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIHERWKCDGE               NOV28k   QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCVRSDFTCDNGHCIHERWKCDGE               NOV28l   QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIHERWKCDGE               NOV28a   EECPDGSDESEATCTLGTCRGDEFQC--GDGTCVLAIKHCNQEQDCPDGSDEAGCLQE--               NOV28b   EECPDGSDESEATCTKQVC-----------------------------------------               NOV28c   EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATS--               NOV28d   EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATS--               NOV28e   EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCA               NOV28f   EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATS--               NOV28g   EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATS--               NOV28h   EECPDGSDESEATCTLGTCRGDEFQC--GDGTCVLAIKHCNQEQDCPDGSDEAGCLQE--               NOV28l   EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATS--               NOV28   EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATS--               NOV28k   EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATS--               NOV28l   EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCA               NOV28a   ------------------------------------------------------------               NOV28b   ------------------------------------------------------------               NOV28c   ------------------------------------------------------------               NOV28d   ------------------------------------------------------------               NOV28e   PHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVC               NOV28f   ------------------------------------------------------------               NOV28g   ------------------------------------------------------------               NOV28h   ------------------------------------------------------------               NOV28i   ------------------------------------------------------------               NOV28   ------------------------------------------------------------               NOV28k   ------------------------------------------------------------               NOV28l   PHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVC               NOV28a   ------------------------------------------------------------               NOV28b   ------------------------------------------------------------               NOV28c   ------------------------------------------------------------               NOV28d   ------------------------------------------------------------               NOV28e   DRQFDCEDRSDEAAELCGRPGPGATSAPAACATVSQFACRSGECVHLGWRCDGDRDCKDK               NOV28f   ------------------------------------------------------------               NOV28g   ------------------------------------------------------------               NOV28h   ------------------------------------------------------------               NOV28i   ------------------------------------------------------------               NOV28   ------------------------------------------------------------               NOV28k   ------------------------------------------------------------               NOV28l   DRQFDCEDRSDEAAELCGRPGPGATSAPAACATVSQFACRSGECVHLGWRCDGDRDCKDK               NOV28a   -------SPCEGPRRFQCKSGKRVDGGKVCDVQRDCRDWSDELLKVWCGACLRPLAGLSL               NOV28c   -------LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG------------               NOV28d   -------LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG------------               NOV28e   SDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQESPCEGPRRFQCK               NOV28f   -------LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG------------               NOV28g   -------LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG------------               NOV28h   -------SPCEGPRRFQCKSGKRVDGGKVCDVQRDCRDWSDELLKVWCGACLRPLAGLSL               NOV28i   -------LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG------------               NOV28   -------LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG------------               NOV28k   -------LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG------------               NOV28a   LPSPSWYLGSRPSSAPCPDTFCSDPLFGFMCRPMASHGAFRPQASGLHLYKVLRACPSQR               NOV28b   ------------------------------------------------------------               NOV28c   ------------------------------------------------------------               NOV28d   ------------------------------------------------------------               NOV28e   SGKRVDGGKVCDVQRDCRDWSDELLKVWCVSYHPPPG-----------------------               NOV28f   ------------------------------------------------------------               NOV28g   ------------------------------------------------------------               NOV28h   LPSPSWSPCP----SP-------------------G------------------------               NOV28i   G-----------------------------------------------------------               NOV28   ------------------------------------------------------------               NOV28k   ------------------------------------------------------------               NOV28l   ------------------------------------------------------------               NOV28a   RLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG               NOV28b   ------------------------------------------------------------               NOV28c   -LNECLHNNGGCSHICADLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG               NOV28d   -LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCG--------------------               NOV28e   -LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG               NOV28f   -LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG               NOV28g   -LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCG--------------------               NOV28h   -LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG               NOV28i   -LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQTCVNYKG               NOV28   -LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG               NOV28k   -LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG               NOV28l   -LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG               NOV28a   YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVAL               NOV28b   ------------------------------------------------------------               NOV28c   YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVAL               NOV28d   ----------------------AGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVAL               NOV28e   YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVAL               NOV28f   YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVAL               NOV28g   ----------------------AGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVAL               NOV28h   YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVAL               NOV28i   YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVAL               NOV28   YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVAL               NOV28k   YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVAL               NOV28l   YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRYEVRRIDLVKRNYSRLIPMLKNVVAL               NOV28a   DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD               NOV28b   -----------------------------------------------------P--AEK-               NOV28c   DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD               NOV28d   DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD               NOV28e   DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD               NOV28f   DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD               NOV28g   DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD               NOV28h   DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD               NOV28i   DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD               NOV28   DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD               NOV28k   DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD               NOV28l   DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD               NOV28a   SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR               NOV28b   ------------------------------------------------------------               NOV28c   SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR               NOV28d   SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR               NOV28e   SGNKTISVATVDGGRPRTLFSRNLSEPBAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR               NOV28f   SGN-----KNISGGRRRTLFSRNLSEPPAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR               NOV28g   SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGvDR               NOV28h   SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR               NOV28i   SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR               NOV28   SGNKTISVATVDGGRPRTLFSRNLSEPRAIAVGPLRGFMYWSDWGDQAKIEKSGLNGVDR               NOV28k   SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR               NOV28l   SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR               NOV28a   QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA               NOV28b   ------------------------------------------------------------               NOV28c   QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA               NOV28d   QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA               NOV28e   QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA               NOV28f   QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA               NOV28g   QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA               NOV28h   QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA               NOV28i   QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA               NOV28   QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA               NOV28k   QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA               NOV28l   QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA               NOV28a   VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQ               NOV28b   ------------------------------------------------------------               NOV28c   VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQ               NOV28d   VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPEAPDACELSVQ               NOV28e   VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQ               NOV28f   VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQ               NOV28g   VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPPAPDACELSVQ               NOV28h   VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQ               NOV28i   VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQ               NOV28   VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQ               NOV28k   VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQ               NOV28l   VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQ               NOV28a   PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP-----------------               NOV28b   -------------------------------LGPDMKRCYFAP-----------------               NOV28c   PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP-----------------               NOV28d   PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYEAP-----------------               NOV28e   PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYEAPQSTSTTTLASTMTRTVP               NOV28f   PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRD------------------               NOV28g   PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP-----------------               NOV28h   PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP-----------------               NOV28i   PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP-----------------               NOV28   PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVP               NOV28k   PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP-----------------               NOV28l   PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVP               NOV28a   ------------------------------------------------------------               NOV28b   ------------------------------------------------------------               NOV28c   ------------------------------------------------------------               NOV28d   ------------------------------------------------------------               NOV28e   ATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANE               NOV28f   ---------------------------------------------------------ANE               NOV28g   ------------------------------------------------------------               NOV28h   ------------------------------------------------------------               NOV28i   ------------------------------------------------------------               NOV28   ATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANE               NOV28k   ------------------------------------------------------------               NOV28l   ATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANE               NOV28a   -QSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSIS               NOV28b   -QSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPPAPSIS               NOV28c   -QSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRVPSIS               NOV28d   -QSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSIS               NOV28e   DSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKN-TKSMMFDNPVYRKTTEEED               NOV28f   DSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKN-TKSMMFDNPVYRKTTEEED               NOV28g   -QSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSIS               NOV28h   -QSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSIS               NOV28i   -QSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSIS               NOV28   DSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKN-TKSMMFDNPVYRKTTEEED               NOV28k   -QSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSIS               NOV28l   DSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKN-TKSMMFDNPVYRKTTEEED               NOV28a   PSTLSPATSNHSQHYANEDSKNGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWK-----               NOV28b   PSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVTALLCMSGYLIWRNWK-----               NOV28c   P-----------------------------------------------------------               NOV28d   PSTLSPATSNHSQHAN-EDSKMGSTVTAAVIGIIVPIANEDSKMGSTVTAAVIGIIVPIG               NOV28e   E-----------------------------------------------------------               NOV28f   E-----------------------------------------------------------               NOV28g   PSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIV-------------VIALLCMSG               NOV28h   PSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWK-----               NOV28i   P-----------------------------------------------------------               NOV28   E-----------------------------------------------------------               NOV28k   P-----------------------------------------------------------               NOV28l   E-----------------------------------------------------------               NOV28a   ----------------RKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISS               NOV28b   ----------------RKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISS               NOV28c   ---------------------------------------STLRPATSNHSQHYAN-----               NOV28d   DSPPVHEWIPDLEKLEAEEHQKHEFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISS               NOV28e   ---------------------------------------DELHIGRTAQIGHVYPAAISS               NOV28f   ---------------------------------------DELHIGRTAQIGHVYP-----               NOV28g   -------YLIWRNWKRKNTKSMNFDNPVYRICTTEEEDEDELHIGRTAQIGHVYPAAISS               NOV28h   ---------------RKNTKSMNFDNPVYRICTTEEEDEDELHIGRTAQIGHVYPAAISS               NOV28i   ---------------------------------------STLSPATSNHSQHYAN-----               NOV28   ---------------------------------------DELHIGRTAQIGHVYP-----               NOV28k   ---------------------------------------STLSPATSNHSQHYAN-----               NOV28l   ---------------------------------------DELHIGRTAQIGHVYPAAISS               NOV28a   FDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSK-RVAL               NOV28b   FDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSK-RVAL               NOV28c   ------------------------------------------------------------               NOV28d   FDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKQRVAL               NOV28e   FDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSK-RVAL               NOV28f   ------------------------------------------------------A-RVAL               NOV28g   FDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSK-RVAL               NOV28h   FDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSK-RVAL               NOV28i   ------------------------------------------------------------               NOV28   ------------------------------------------------------A-RVAL               NOV28k   ------------------------------------------------------------               NOV28l   FDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSK-RVAL               NOV28a   SLEDDGLP----------------------------------------------------               NOV28b   SLEDDGLP----------------------------------------------------               NOV28c   --EDSKLE----------------------------------------------------               NOV28d   SLEDDGLP----------------------------------------------------               NOV28e   SLEDDGLP----------------------------------------------------               NOV28f   SLEDDGLP----------------------------------------------------               NOV28g   SLEDDGLP----------------------------------------------------               NOV28h   SLEDDGLP----------------------------------------------------               NOV28i   --EDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEE               NOV28   SLEDDGLP----------------------------------------------------               NOV28k   --EDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEE               NOV28l   SLEDDGLP----------------------------------------------------               NOV28a   ------------------------------------------------------------               NOV28b   ------------------------------------------------------------               NOV28d   ------------------------------------------------------------               NOV28e   ------------------------------------------------------------               NOV28f   ------------------------------------------------------------               NOV28g   ------------------------------------------------------------               NOV28h   ------------------------------------------------------------               NOV28i   EDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRS               NOV28   ------------------------------------------------------------               NOV28k   EDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRS               NOV28l   ------------------------------------------------------------               NOV28a   -------------------------------               NOV28d   -------------------------------               NOV28e   -------------------------------               NOV28f   -------------------------------               NOV28g   -------------------------------               NOV28h   -------------------------------               NOV28i   QLHQLPKNPLSELPVVKSKRVALSLEDDGLP               NOV28   -------------------------------               NOV28k   QLHQLPKNPLSELPVVKSKRVALSLEDDGLP               NOV28l   -------------------------------                  
 
      Further analysis of the NOV28a protein yielded the following properties shown in Table 28C.  
               TABLE 28C                       Protein Sequence Properties NOV28a                                        SignalP analysis:   Cleavage site between residues 33 and 34       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 10; pos. chg 1; neg. chg 1           H-region:   length 14; peak value 11.70           PSG score:   7.30                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 4.70           possible cleavage site: between 26 and 27                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 26)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 27           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 768-784               −13.80                             PERIPHERAL   Likelihood = 2.81 (at 203)                         ALOM score: −13.80 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 13           Charge difference: −0.5 C(0.5)-N(1.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 1a (cytoplasmic tail 785 to 905)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   2   Hyd Moment(75):   5.68           Hyd Moment(95):   4.45   G content:   2           D/E content:   2   S/T content:   0                         Score: −6.43       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 35 LRL|QH                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: PVVKSKR (3) at 888           bipartite: none           content of basic residues: 10.3%           NLS Score: −0.22       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         44.4%: extracellular, including cell wall           22.2%: Golgi           22.2%: endoplasmic reticulum           11.1%: plasma membrane                 &gt;&gt; prediction for CG55256-07 is exc (k = 9)                  
 
      A search of the NOV28a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 28D.  
               TABLE 28D                          Geneseq Results for NOV28a                                         NOV28a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               AAU91290   Human NOV5i protein -  Homo sapiens ,   1 . . . 905   903/905 (99%)   0.0           905 aa. [WO200216600-A2, 28-FEB-2002]   1 . . . 905   903/905 (99%)       AAU91288   Human NOV5g protein -  Homo sapiens , 857 aa.   1 . . . 905   851/905 (94%)   0.0           [WO200216600-A2, 28-FEB-2002]   1 . . . 857   854/905 (94%)       ABP56838   Human apolipoprotein E receptor 2 protein   1 . . . 905   800/973 (82%)   0.0           SEQ ID NO: 5 -  Homo sapiens ,   1 . . . 963   817/973 (83%)           963 aa. [WO200299438-A2, 12-DEC-2002]       AAU91289   Human NOV5h protein -  Homo sapiens ,   1 . . . 905   786/908 (86%)   0.0           847 aa. [WO200216600-A2, 28-FEB-2002]   1 . . . 847   802/908 (87%)       AAU91285   Human NOV5d protein -  Homo sapiens ,   42 . . . 905   704/884 (79%)   0.0           1012 aa. [WO200216600-A2, 28-FEB-2002]   162 . . . 1012   724/884 (81%)                  
 
      In a BLAST search of public sequence databases, the NOV28a protein was found to have homology to the proteins shown in the BLASTP data in Table 28E.  
               TABLE 28E                          Public BLASTP Results for NOV28a                                         NOV28a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             Q14114   Apolipoprotein E receptor 2   1 . . . 905   800/973   (82%)   0.0           precursor -  Homo sapiens     1 . . . 963   817/973   (83%)           (Human), 963 aa.       Q921B6   ApoE receptor-2 -  Mus musculus     1 . . . 905   719/912   (78%)   0.0           (Mouse), 870 aa.   1 . . . 870   766/912   (83%)       O14968   ApoER2delta4-7 -  Homo sapiens     1 . . . 905   721/907   (79%)   0.0           (Human), 793 aa.   1 . . . 793   736/907   (80%)       Q924X6   Apolipoprotein E receptor 2   1 . . . 905   689/1011   (68%)   0.0           precursor -  Mus musculus     1 . . . 996   743/1011   (73%)           (Mouse), 996 aa.       JE0237   apolipoprotein E receptor 2   1 . . . 905   689/1009   (68%)   0.0           precursor- mouse, 996 aa.   1 . . . 996   742/1009   (73%)                  
 
      PFam analysis predicts that the NOV28a protein contains the domains shown in the Table 28F.  
               TABLE 28F                          Domain Analysis of NOV28a                                     Identities/                   Similarities           NOV28a Match   for the   Expect       Pfam Domain   Region   Matched Region   Value               Idl_recept_a    45 . . . 83   20/43 (47%)   7.7e−13               32/43 (74%)       Idl_recept_a    84 . . . 124   19/43 (44%)   2.8e−13               32/43 (74%)       Idl_recept_a   125 . . . 163   19/43 (44%)   1.2e−11               32/43 (74%)       Idl_recept_a   165 . . . 207   20/44 (45%)   1.3e−07               33/44 (75%)       EGF   282 . . . 316   14/47 (30%)     9e−06               27/47 (57%)       TIL   273 . . . 322   13/67 (19%)   0.33               29/67 (43%)       EGF   322 . . . 356   15/47 (32%)   0.5                27/47 (57%)       Idl_recept_b   404 . . . 449   17/48 (35%)   1.2e−10               40/48 (83%)       Idl_recept_b   451 . . . 492   23/47 (49%)   2.3e−15               40/47 (85%)       Idl_recept_b   494 . . . 536   19/47 (40%)     2e−15               38/47 (81%)       Idl_recept_b   538 . . . 581   21/47 (45%)   2.9e−12               39/47 (83%)       Idl_recept_b   582 . . . 622   12/47 (26%)   1.5e−08               37/47 (79%)                  
 
     Example 29  
      The NOV29 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 29A.  
               TABLE 29A                       NOV29 Sequence Analysis                                                NOV29a, CG55776-01   SEQ ID NO:665   7876 bp           DNA Sequence   ORF Start: ATG at 6   ORF Stop: TGA at 7857                       TCAGG   ATG AAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCCTGGTC           GCCACCCCTGGGGGCAAGGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCAC       ATTTCGGTACCTGACTTCCATCCCAGACAGCATCCCGCCCAATGTGAACGCAATGAATTTAGGGTACA       ACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCAC       AGCAATGGCATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTGAGACTGAT       GGTCTTAAAAATGAGCTATAATAAAGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCT       TGACACGATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAAC       TTTCTCCGCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTT       GAGCTACCTCCAGATATTTAAAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCT       CCCTCCCTCAAGAGATGGTCTCCTATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGG       ACCTGTGATTGCCATTTAAAGTGGTTGTCTGACTGGATACAGGAGAAGCCAGGTATCTATATTGTNTT       ACCAGATGTAATAAAATGCAAAAAAGATAGAAGTCCCTCTAGTGCTCAGCAGTGTCCACTTTGCATGA       ACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTGCAGCTTTCCAGTGTACAAAGCCA       ACCATTGACTCATCCCTGAAATCAAAGAGCCTGACTATTCTGGAAGACAGTAGTTCTGCTTTCATCTC       TCCCCAAGGTTTCATGGCACCCTTTGGCTCCCTCACTTTGAATATGACAGATCAGTCTGGAAATGAAG       CTAACATGGTCTGCAGTATTCAAAAGCCCTCAAGGACATCACCCATTGCATTCACTGAAGAAAATGAC       TACATCGTGCTAAATACTTCAATTTTCACATTTTTGGTGTGCAACATAGATTACGGTCACATTCAGCC       AGTGTGGCAAAATTTTGGCTTTGTACAGTGATTCTCCTCTGATACTAGAAAGGAACACTTGCTTAGTG       AAACACCGCAGCTCTATTACAAATATAAACAGGTGGCTCCTAAGCCTGAAGACATTTTTACCAACATA       GAGGCAGATCTCAGAGCAGATCCCTCTTGGTTAATGCAAGACCAAATTTCCTTGCAGCTGAACAGAAC       TGCCACCACATTCAGTACATTACAGATCCAGTACTCCAGTGATGCTCAAATCACTTTACCAAGAGCAG       AGATGAGGCCAGTGAAACACAAATGGACTATGATTTCAAGGGATAACAATACTAAGCTGGAACATACT       GTCTTGGTAGGTGGAACCGTTGGCCTGAACTGCCCAGGCCAAGGAGACCCCACCCCACACGTGGATTG       GCTTCTAGCTGATGGAAGTAAAGTGAGAGCCCCTTATGTCAGTGAGGATGGACGGATCCTAATAGACA       AAAGTGGAAAATTGGAACTCCAGATGGCTGATAGTTTTGACACAGGCGTATATCACTGTATAAGCAGC       AATTATGATGATGCAGATATTCTCACCTATAGGATAACTGTGGTAGAACCTTTGGTCGAAGCCTATCA       GGAAAATGGGATTCATCACACAGTTTTCATTGGTGAAACACTTGATCTTCCATGCCATTCTACTGGTA       TCCCAGATGCCTCTATTAGCTGGGTTATTCCAGGACAATGTGCTCTATCAGTCATCAAAGAGACAAAG       AAAGTTCTAAACAATGGCACATTAAGAATATTACAGGTCACCCCGAAAGACCAAGGTTATTATCGCTG       TGTGGCAGCCAACCCATCAGGGGTTGATTTTTTGATTTTCCAAGTTTCAGTCAAGATGAAAGGACAAA       GGCCCTTGGAGCATGATGGAGAAACAGAGGGATCTGGACTTGATGAGTCCAATCCTATTGCTCATCTT       AAGGAGCCACCAGGTGCACAACTCCGTACATCTGCTCTGATGGAGGCTGAGGTTGGAAAACACACCTC       AAGCAACAAGTAAGAGGCACACTATCGGGAATTAACACTCCAGCGACGTGGAGATTCAACACATCGAC       GTTTTAGGGAGAATAGGAGGCATTTCCCTCCCTCTGCTAGGAGAATTGACCCACAACATTGGGCGGCA       CTGTTGGAGAAAGCTAAAAAGAATGCTATGCCAGACAAGCGAGAAAATACCACAGTGAGCCCACCCCC       AGGAATTTATGGTCCCGGCCACTAAAGCTTTGAACCTTCCAGCAAGGACAGTGACTGCTGACTCCAGA       ACAATATCTGATAGTCCTATGACAAACATAAATTATGGCACAGAATTCTCTCCTGTTGTGAATTCACA       AATACTACCACCTGAAGAACCCACAGATTTCAAACTGTCTACTGCTATTAAACTACAGCCATGTCAAA       AGAATATAAACCCAACCATGTCAAGCCAAATACAAGGCACAACCAATCAACATTCATCCACTGTCTTT       CCACTGCTACTTGGAGCAAACTGAATTTCAGGACTCTGACCAGATGGGAAGAGGAGAGAGCATTTCCA       AAGTAGACCCCCAATAACAAGTAAGACTATGATCAAAGATGTCAATGTCAAAATGCTTAGTAGCACCA       CCAACAAACTATTATTAGAGTCAGTAAATACCACAAATAGTCATCAGACATCTGTAAGAGAAGTGAGT       GAACCCAGGCACAATCACTTCTATTCTCACACTACTCAAATACTTAGCACCTCCACGTTCCCTTCAGA       TCCACACACAGCTGCTCATTCTCAGTTTCCGATCCCTAGAAATAGTACAGTTAACATCCCGCTGTTCA       GACGCTTTGGGAGGCAGAGGAAAATTGGCGGAAGGGGGCGGATTATCAGCCCATATAGAACTCCAGTT       CTGCGACGGCATAGATACAGCATTTTCAGGTCAACAACCAGAGGTTCTTCTGAAAAAAGCACTACTGC       ATTCTCAGCCACAGTGCTCAATGTGACATGTCTGTCCTGTCTTCCCAGGGAGAGGCTCACCACTGCCA       CAGCAGCATTGTCTTTTCCAAGTGCTGCTCCCATCACCTTCCCCAAAGCTGACATTGCTAGAGTCCCA               TCAGAAGAGTCTACAACTCTAGTCCAGAATCCACTATTACTACTTGAGAACAAACCCAGTGTAGAGAA       AACAACACCCACAATAAAATATTTCAGGACTGAAATTTCCCAAGTGACTCCAACTGGTGCAGTCATGA       AGCACCAATGAAGCTAAAAGAGATTCAGTGATTACATCGTCACTTTCAGGTGCTATCACCAAGCCACC       ATTGACTATTATAGCCATTACAAGGTTTTCAAGAAGGAAAATTCCCTGGCAACAGAACTTTGTAAATA       ACCATAACCCAAAAGGCAGATTAAGGAATCAACATAAGTTAGTTTACAAAAAAGCACAACATGTGATG       CTTCCTAAAACATCTCCTGCTTTACCACAGAGACAAAGTCTCCCCTCGCACCACACTACGACCAAAAC       ACACAATCCTGGAAGTCTTCCAACAAAGAAGGAGCTTCCCTTCCCACCCCTTAACCCTATGCTTCCTA       GTATTATAAGCAAAGACTCAAGTACAAAAAGCATCATATCAACGCAAACAGCAATACCAGCAACAACT       CCTACCTTCCCTGCATCTGTCATCACTTATGAAACCCAAACAGAGAGATCTAGAGCACAAACAATACA       TCACTACACCCACTGCTATGACACCTCCTGTTCTAACCACAGCCGAAACTTCAGTCAAGCCCAGTGTC       TCTGCATTCACTCATTCCCCACCAGAAAACACAACTGGGATTTCAAGCACAATCAGTTTTCATTCAAG       AACTCTTAATCTGACAGATGTGATTGAAGAACTAGCCCAAGCAAGTACTCAGACTTTGAAGAGCACAA       TTGCTTCTGAAACAACTTTGTCCAGCAAATCACACCAGAGTACCAACACTAGGAAAGCAATCATTAGA       CACTCAACCATACCACCATTCTTGAGCAGCAGTGCTACTCTAATGCCAGTTCCCATCTCCCCTCCCTT       TACTCAGAGAGCAGTTACTGACAACGTGGCGACTCCCATTTCCGGGCTTATGACAAATACAGTGGTCA       AAGGTTCACCCAAATGCCAAGTTCACAATTGGAACCACTCACTTCATCTACTCTAATCTGTTACATTC       TACTCCCATGCCAGCACTAACAACAGTTAAATCACAGAATTCTAAATTAACTCCATCTCCCTGGGCAG       AAAACCAATTTTGGCACAAACCATACTCAGAAATTGCTGAAAAAGGCAAAAAGCCAGAAGTAAGCATG       TTGGCTACTACAGGCCTGTCCGAGGCCACCACTCTTGTTTCAGATTGGGATGGACAGAAGAACACAAA       GAAGAGTGACTTTGATAAGAAACCAGTTCAAGAAGCAACAACTTCCAAACTCCTTCCCTTTGACTCTT       TGTCTAGGTATATATTTGAAAAGCCCAGGATAGTTGGAGGAAAAGCTGCAAGTTTTACTATTCCAGCT       AACTCAGATGCCTTTCTTCCCTGTGAAGCTGTTGGAAATCCCCTGCCCACCATTCATTGGACCAGAGT       CCCATCAGGTATGTCAGGACTTGATTTATCTAAGAGGAAACAGAATAGCAGGGTCCAGGTTCTCCCCA       ATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAAT       CTGTTTGGCACAGACCACCTTCATGTCACCTTGTCTGTGGTTTCCTATCCTCCCAGGATCCTGGAGAG       ACGTACCAAAGAGATCACAGTTCATTCCGGAAGCACTGTGGAACTGAAGTGCAGAGCAGAAGGTAGGC       CAAGCCCTACAGTTACCTGGATTCTTGCAAACCAAIACAGTTGTCTCAGAATCATCCCAGGGAGTAGG       CAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTATGACCGTGGCTTTTA       CAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAAATACAAGTCATTGCAGCAC       CACCTGTTATTCTAGAGCAAAGGAGGCAAGTCATTGTAGGCACTTGGGGTGAAAGTTTAAAACTGCCC       TGTACTGCAAAGGAACTCCTCAGCCCAGCGTTTACTGGGTCCTCTCTGATGGCACTGAAGTGAAAACC       ATTACAGTTTACCAATTCCAAGTTGTTCTTATTTTCAAATGGGACTTTGTATATAAGAAACCTAGCCT       CTTCAGACAGGGGCACTTATGAATGCATTGCTACCAGTTCCACTGATTCGGAGCGAAGAGTAGTAATG       CTTACAATGGAAGAGCGAGTGACCAGCCCCAGGATAGAAGCTGCATCCCAGAAAGGACTGAAGTGAAA       TTTTGGGGACAAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCAAATAATGTGGAGGT       TACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGGTGGGCAGCTGGATCCACGTCTACCCTTATGGA       TCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGTCTACTTGTGTGTGGCAAGAAACAAAAT       GGGGGAATGATCTGATACTGATGCATGTTAGCCTAAGACTGAPAACCTGCCAATTGACCACAAGCAGT       ATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTAGATTGCAAAGCTTCCGGCTCCCCAGTG       CCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAATGCAAGCCGATGACAGTGG       CCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTTTATACTTCAACAAAGTTGGGGTAGCGG       AGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGGAAGATGAAATGAAAGGTCCACTTAACA       GTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAACCAAACAAGAGAATCAAAAGCTGGAGACAC       ACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCCAAATGGGTCTTTGACCAATCAACAGTG       AAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGATGACACCAAAATGTA               CAAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTCTGTATACAAACAGAACTGTTATTAAAG       CCACAGCTGTGAGACATTCCAAAAACACTTTGACTGCAGAGCTGAAGGGACACCATCTCCTGAAAGTC       ATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAGAATCACAGTCCATAA       AAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTATCTGTGTGGCCCGAA       ATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTGAGAAGACCGACATTT       AGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATTGAATTGCTCTGTTGA       TGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATGGCACACGATTTTCCAATGGACCACAAA       GTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATTTCTAAAACAACTCGGGAGGATGCAGGA       AAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCATATTAGAAATTGGCCA       GAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAGAATCTCTATCACTGC       ATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGTGGTTATGTAGTAGAC       AGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCATTAAAGAAGCAACAGC       TTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACACTGATTACTGTTCCAG       TAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATTGTCACCAGGACAGGG       GCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCACATGGGAGATGCCTGA       CCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGCTTCACTTACAAGGTA       CCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACAGCAAAGAACCCACTT       GGTAGTGATTATGCAGCAACGTATATTCAAGTAATCTGACA TGA   AATAATAAAGTC                                           NOV29a, CG55776-01   SEQ ID NO:666   2617 aa   MW at 290200.2 kD           Protein Sequence                     MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNS           LVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVRLMVLKMSYNKVRKLQKDTFYGLRSLT       RLHNDHIANIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKSFIKFLYLSDNFLTSL       PQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPGIYIVLPDVIKCKKDRSPSSAQQCPLCMNP       RTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNNTDQSGNEAN       MVCSIQKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSET       PQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEM       RPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKKAAPYVSEDGRILIDKS       GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP       DASISWVIPGNNVLYQSSRDKKVLNNGTLRTLQVTPKDQGYYRCVAPAPSGVDFLIFQVSVKMKGQRP       LEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRF       RENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEE       FMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKN       INPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTN       KLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRR       FGRQRKIGGRGRIISPYRTPVLPRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERATTATA       ALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTY       APTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPWQQNFVNNH       NPKGRLRNQHKVSLQKSTAVMLPKTSPALPQRQSLPSHHTTTKTHNPGSLPTKKELPFPPLNPMLPSI       ISKDSSTKSIISTQTAIPATTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFT       TPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIA       SETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTNTVVKL       HESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAEN       QFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLS       RYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGMSGLDLSKRKQNSRVQVLPNG       TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS       PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP       VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIAILASS       DRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMARLP       SKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF       RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE       GDYTCYAQNTLGKDEMKVHLnTITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDM       ISFSIDRYTFHANGSLTINKNKLLDSGEVCVARNPSGDDDTKMYKLDVVSKPPLINGLYTNRTVIKAT       AVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE       GGESVLVVQLEVLAEMLRRPTFRNPFNEKMAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSY       QYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHC       VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVM       IVAYPPRITRPPRSIVTRTGAAFQLHCVALAGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTL       VIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI                                     NOV29b, 248210167   SEQ ID NO:667   475 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       C ACCCTCGAGAATGTGGAACGCATCAATTTAGGGTACAACAGCTTGGTTAGATTGATGGAAACAGATT           TTTCTGGCCTGACCAAACTGGACTTACTCATGCTTCACAGCAATGGCATTCACACAATCCCTGACAAG       AGATACTTTTTATGGCCTCAGGAGCTTGACACGATTGCACATGGACCACAACAATATTGAGTTTATAA       ACCCAGAGGTTTTTGATGGGCTCAACTTTCTCCGCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAG       CTCCACCCAGATACATTTGTCTCTTTGAGCTACCTCCAGATATTTAAAATCTCTTTCATTAAGTTCCT       ATACTTGTCTGATAACTTCCTGACCTCCCTCCCTCAAGAGATGGTCTCCTATATGCCTCTCGAGGGC                                         NOV29b, 248210167   SEQ ID NO:668   158 aa   MW at 18415.2 kD           Protein Sequence                     TLENVERINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQK           DTFYGLRSLTRLHMDHNNIEFINPEVFDGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFL       YLSDNFLTSLPQEMVSYMPLEG                                     NOV29c, 247679561   SEQ ID NO:669   2011 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       A GGCTCCGCGGCCGCCCCCTTCACCCTCGAGGGGGACAATTACTACTGAAACTGCTCAGCCACTGGGG           AGCCCAAACCCCAAATAATGTGGAGGTTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGAGTGGGC       AGCTGGATCCACGTCTACCCTAATGGATCCCTGTTTATTGGATCAGTACAGAAAAAAGACAGTGGTGT       CTACTTGTGTGTGGCAAGAAACAAAATGGGGGATGATCTGATACTGATGCATGTTAGCCTAAGACTGA       AACCTGCCAAAATTGACCACAAGCAGTATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTA       GATTGCAAAGCTTCCGGCTCCCCAGTGCCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAA       CAATGGATGCAAGCCGATGACAGTGGCCACAGGACTAGGAGATATACCCTTTTCAAACAATGGAACTT       TATACTTCAACAAAGTTGGGGTAGCGGAGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGG       AAAGATGAAATGAAGGTCCACTTAACAGTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAAC       CAACAAGAGAATCAAGCTGGAGACACAGCTGTCCTTGACTGTGAGGTCACTGAGATCCCAAAACCAAA       AAATATTTTGGTTGCTGCCTTCCAATGACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCC       AATGGGTCTTTGACCATCAACAAAGTGAAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAA       TCCCAGTGGGGATGACACCAATGTACAAACTGGATGTGGTCTCTAAACCTCCAATTAATCAAATGGTC       TGTATACAAACAGAACTGTTATTAAAGCCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGA       GCTGAAGGGACACCATCTCCTGAAGTCATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATA       CTATGGAAGCAGAATCACAGTCCATAAAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATT       CAGCCGACTTTATCTGTGTGGCCCGAAATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTA       CTGGAAATGCTGAGAAGACCGACATTTAGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAA       GTCCACAGCATTGAATTGCTCTGTTGATGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATG       GCACACGATTTTCCAATGGACCACAAAGTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATT       TCTAAAACAACTCGGGAGGATGCAGGAAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAA       GAAATTAGTCATATTAGAAATTGGCCAGAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAG       GCATCAGTGGAGAATCTCTATCACTGCATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGG       ACTATGCCAAGTGGTTATGTAGTAGACAGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGG       CACCTTAGTCATTAAAGAAGCAACAGCTTATGACAGAGGAACTATATCTGTAAGGCTCAAAAAAAGTG       TTGGTCATACACTGATTACTGTTCCAGTAATGATTGTAGCCTACCCTCCCCGAATTACAATCGTCCAA       CCCAGGAGTATTGTCACCAGGACAGGGGCAGCCTTTCAGCTCCACTGTGTGGcCTTGGGAGTTCCCAA       GCCAGAATCACATGGGAQATGCCTGACCACTCCCTTCTCTCAAACGGCAAAGTAAGAGAGGACACATG       GAAAGTGAGCAGCTTCACTTACAAGGTACCCTAGTCATTCAGATCCCCAAAQCTCCGATTCTGGGATA       TACAAATGCACAGCACTCGAGGGCAAGGGTGGGCGCGCC                                         NOV29c, 247679561   SEQ ID NO:670   670 aa   MW at 73997.1 kD           Protein Sequence                     GSAAAPFTLEGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGV           YLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMIN       NAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKT       NKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARN       PSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPY       YGSRIIVHKNGTLERIAVRLSDSADFICVARNEGGESVLVVQLEVLEMIRRPTFRNPFNEKIVAQLGK       STALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIE       KLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNG       TLVIKATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRIITNRPPRSIVTRTGAAFQLHCVALGVPK       PEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTALEGKGGRA                                     NOV29d, 248057904   SEQ ID NO:671   771 bP           DNA Sequence   ORF Start: at 1   ORF Stop: end of Sequence                     AAGCTTGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCACATTTCGGTACCT           GACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGATACAACAGCTTGGTTA       GATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCACAGCAATGGCATT       CACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTCTTAAAAATGAGCTATAATAA       AGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCTTGACACGATTGCACATGGACCACA       ACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAACTTTCTCCGCCTGGTGCACTTGGAA       GGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTTGAGCTACCTCCAGATATTTAAAAT       CTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCTCCCTCCCTCAAGAGATGGTCTCCT       ATATGCCTGACCTAGACAGCCTTTACCTGCATAAACCCATGGAAACCTGTGATTGCCATTTAAAGTGG       TTGTCTGACTGGATACAGGAGAAGCCAGATGTATAAATGCAAAAAGAATAAGAAAGTCCCTCTAGTGC       TCAGCAGTGTCCACTTTGCATGAACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTG       CAGCTTTCCAGTGTGCCCTCGAG                                         NOV29d, 248057904   SEQ ID NO:672   257 aa   MW at 29661.2 kD           Protein Sequence                     KLACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLMLHSNGI           HTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLE       GNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYNPDLDSLYLHGNPWTCDCHLKW       LSDWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAAFQCALE                                     NOV29e, 248057927   SEQ ID NO:673   771 bP           DNA Sequence   ORF Start: at 1   ORF Stop: end of Sequence                     AAGCTTGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCACATTTCGGTACCT           GACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGATACAACAGCTTGGTTA       GATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCACAGCAATGGCATT       CACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTCTTAAAAATGAGCTATAACAA       AGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCTTGACACGATTGCACATGGACCACA       ACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAACTTTCTCCGCCTGGTGCACTTGGAA       GGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTTGAGCTACCTCCAGATATTTAAAAT       CTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCTCCCTCCCTCAAGAGATGGTCTCCT       ATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGGACCTGTGATTGCCATTTAAAGTGG       TTGTCTGACTGGATACAGGAGAIAGCCAGATGTAATAAATGCAAAAAAGATAGAAGTCCCTCTAGTGC       TCAGTAGTGTCCACTTTGCATGAACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTG       CAGCTTTCCAGTGTGCCCTCGAG                                         NOV29e, 248057927   SEQ ID NO:674   257 aa   MW at 29661.2 kD           Protein Sequence                     KLACPPRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLMLHSNGI           HTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLE       GNQLTKAHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKW       LSDWIQEKPDVIKCKKDRSPSSAQQCPLCNNPRTSKGKPLAMVSAAAFQCALE                                     NOV29f, 249239821   SEQ ID NO:675   771 bP           DNA Sequence   ORF Start: at 1   ORF Stop: end of Sequence                     AAGCTTGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCACATTTCGGTACCT           GACTTCCATCCCAGACAGCATCCCGCCCATGTGGAACGCATCAATTTAAGGAATAACACAATTGGTTA       GATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCACAGCAATGGCATT       CACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTCTTAAATGAAGCTATAAACAA       AGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCTTGACACGATTGCACATGGACCACA       ACAATATTGAGTTTATAAACCCAGAGGTTTTTGATGGGCTCAACTTTCTCCGCCTGGTGCACTTGGAA       GGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTTGAGCTACCTCCAGATATTTAAAAT       CTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCTCCCTCCCTCMAGAGATGGTCTCCT       ATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGGACCTGTGATTGCCATTTAAAGTGG       TTGTCTGACTGGATACAGGAGAAGCCAGATGTAATAAATGCAAAAAGATAAGAGTCCCTCTAAAGTGC       TCCGCAGTGTCCACTTTGCATGAACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTG       AGCTTTCCAGTGTGCCCTCGAG                                         NOV29f, 249239821   SEQ ID NO:676   257 aa   MW at 29582.1 kD           Protein Sequence                     KLACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLMLHSNGI           HTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHINNIFINPEVFDGLNFLRLVHLE       GNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKW       LSDWIQEKPDVIKCKKDRSPSSAPQCPLCMNPRTSKGKPLAMVSAAAFQCALE                                     NOV29g, 248057920   SEQ ID NO:677   771 bP           DNA Sequence   ORF Start: at 1   ORF Stop: end of Sequence                     AAGCTTGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCACATTTCGGTACCT           GACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGATACAACAGCTTGGTTA       CACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTCTTAAAAATGAGCTATAACAA       AGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCTTGACACGATTGCACATGGACCACA       ACAATATTGAGTTTATAAACCCAGAGGTTTTTGATGGGCTCAACTTTCTCCGCCTGGTGCACTTGGAA       CTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCTCCCTCCCTCAAGAGATGGTCTCCT       ATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGGAACCTGTGATTGCCATTTAAGTGG       TTGTTTGACTGGATACAGGAGAAGCCAGATGTAATAAAATGCAAAAAAGATAGAAGTCCCTCTAGTGC       TCAGCAGTGTCCACTTTGCATGAACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTG       CAGCTTTCCAGTGTGCCCTCGAG                                         NOV29g, 248057920   SEQ ID NO:678   257aa   MW at 29673.2 kD           Protein Sequence                     KLACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLMLHSNGI           HTIPDKTFSDLQALQVLAMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFDGLNFLRLVHLE       GNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKW       LFDWIQEKPDVIKCKKDRSPSSAQQCPLCAPRTSKGKPLAMVSAAAFQCALE                                     NOV29h, 247679541   SEQ ID NO:679   2059 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       A GGCTCCGCGGCCGCCCCCTTCACCCTCGAGGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGG           AGCCCAAACCCCAAATAATGTGGAGGTTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGAGTGGGC       AGCTGGATCCACGTCTACCCTAATGGATCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGT       CTACTTGTGTGTGGCAAGAAACAAAGGGGGATGATCTGATACTGATGCATGTTAGCCTAAGAAACTGA       AACCTGCCAAATTGACCACAAGCAGTATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAAGTA       GATTGCALAGCTTCCGGCTCCCCAGTGCCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAA       CAATGCAATGCAAGCCGATGACAGTGGCCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTT       TATACTTCAACAAAGTTGGGGTAAGCGGAGGAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGG       AAAGATGAAATGAAGGTCCACTTAACAGTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAAC       CAACAAGAGAATCAAAAGCTGGAGACACAGCTGTCCTTGACTGTGAGGTCACTGAGATCCCAAACCAA       AAATATTTTGGTTGCTGCCTTCCAATGACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCC       AATGGGTCTTTGACCATCAACAAGTGAAACTGCTCGATTCTGGAAGAGTACGTATGTGTAGCCCGAAA       TCCCAGTGGGGAATGACACCAAAATGTAACAACTGGAATGTGGTCTCTAACCTCCATTATCAATGGTC       TGTATACAAATAGAACTGTTATTAAAGCCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGA       GCTGAAGGGACACCATCTCCTGAAGTCATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATA       CTATGGAAGCAGAATCACAGTCCATAAAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATT       CAGCCGACTTTATCTGTGTGGCCCGAAATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTA       CTGGAAATGCTGAGAAGACCGACATTTAGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAA       GTCCACAGCATTGAATTGCTCTGTTGATGGTAACCCACCACCTGAAATATCTGGATTTTAACCAAATG       GCACACGATTTTCCAATGGACCACAAAGTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATT       TCTAAAACAACTCGGGAGGATGCAGGAAAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGA       GAAATTAGTCATATTAGAAATTGGCCAGAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAG       GCATCAGTGGAGAATCTCTATCACTGCATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGG       ACTATGCCAAGTGGTTATGTAGTAGACAGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGG       CACCTTAGTCATTAAAGAAGCAACAGCTTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTG       TTGGTCATACACTGATTACTGTTCCAGTAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCA       CCCAGGAGTATTGTCACCAGGACAGGGGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAA       GCCAGAAATCACGTGGGAGATGCCTGACCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATG       GAAGTGAGCAGCTTCACTTACAAGGTACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATA       TACAAATGCACAGCAAAGAACCCACTTGGTAGTGATTATGCAGCAACGTATATTCAAGTAATCCTCGA       GGGCAAGGGTGGGCGCGCC                                         NOV29h, 247679541   SEQ ID NO:680   686 aa   MW at 75732.1 kD           Protein Sequence                     GSAAAPFTLEGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGV           YLCVAPNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMIN       NKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARN       PSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPY       YGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGK       STALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFTISKTTREDAGKYRCAARNKVGYIE       KLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNG       TLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPK       PEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAIAPLGSDYAATYIQVILE       GKGGRA                                     NOV291, 249116954   SEQ ID NO:681   2011 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       A GGCTCCGCGGCCGCCCCCTTCACCCTCGAGGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGG           AGCCCAAACCCCAAATAATGTGGAGGTTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGAGTGGGC       AGCTGGATCCACGTCTACCCTAATGGATCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGT       CTACTTGTGTGTGGCAAGAAACAAAATGGGGGATGATCTGATACTGATGCATGTTAGCCTAAGACTGA       AACCTGCCAAATTGACCACAAGCAGTATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAAGTA       TATACTTCAACAAAGTTGGGGTAGCGGAGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGG       CAACAAGAGAATCAAAGCTGGAGACACAGCTGTCCTTGACTGTGAGGTCACTGGGGATCCCAAACCAA       AAATATTTTGGTTGCTGCCTTCCAATGACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCC       AATGGGTCTTTGACCATCAACAAAGTGAAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAA       TCCCAGTGGGGATGACACCAAAATGTACAAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTC       TGTATACAAATAGAACTGTTATTAAAGCCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGA       GCTGAAGGGACACCATCTCCTGAAGTCATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATA       CTATGGAAGCAGAATCACAGTCCATAAAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATT       CAGCCGACTTTATCTGTGTGGCCCGAAATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTA       CTGGAAATGCTGAGAAGACCGACATTTAGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAA       GTCCACAGCATTGAATTGCTCTGTTGATGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATG       GCACACGATTTTCCAATGGACCACAGTTATCAGTATCTGATAGCAAGCAAATGGTTCTTTTATCAATT       TCTAAACAACTCGGGAGGATGCAGGAAAATATCGCTGTGCAGCTAGGAATAAAAGTTGGCTATATTGA       GAAATTAGTCATATTAGAAATTGGCCAGAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAG       GCATCAGTGGAGAATCTCTATCACTGCATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGG       ACTATGCCAAGTGGTTATGTACTAGACAGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGG       CACCTTAGTCATTAAAGAAGCAACAGCTTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTG       TTGGTCATACACTGATTACTGTTCCAGTAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCA       CCCAGGAGTATTGTCACCAGGACAGGGGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAA       GCCAGAAATCACGTGGGAGATGCCTGACCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATG       GAAGTGAGCAGCTTCACTTACAAGGTACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATA       TACAAATGCACAGCACTCGAGGGCAAGGGTGGGCGCGCC                                         NOV29i, 249116954   SEQ ID NO:682   670 aa   MW at 73997.1 kD           Protein Sequence                     GSAAAPFTLEGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGV           YLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMIN       NAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKT       NKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMTSFSIDRYTFHANGSLTINKVKLLDSGEYVCVAAA       PSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWTMPDNIFLTAPY       YGSRITVHINGTLEIRNVRLSDSALFICVARIEGGESVLVVQLEVLEMLRRPTFPAPFNEKIVAQLGK       STALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAAAAKVGYIE       KLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNG       TLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPK       PEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTALEGKGGRA                                     NOV29, 248210155   SEQ ID NO:683   1420 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                     CACCCTCGAGGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGT           GGAGGTTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGTACACATTTCATGCCAATGGGTCTTTG       ACCATCAACAAAGTGAAACTGCTCGAATTCTGGAGAGTACGTATGTGTAGCCCGAATCCCAGTGGGGA       TGACACCAAAATGTACAAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTCTGTATACAAATA       GAACTGTTATTAAAGCCACAGCTGTGAGACATTCCAAAAACAACTTTGAACTGCAGAGCTGAGGGACA       CCATCTCCTGAAAGTCATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAGCAG       AATCACAGTCCATAAAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTA       AGAAGAACCGACATTTAGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAGTCCACAGCATT       GAATTGCTCTGTTGATGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATGGCACACGATTTT       ATTAGAAATTGGCCAGAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAG       ATCTCTATCACTGCATTGTGTGTCTGATGGAAATCCCTAAGCCAAAATATCATGGACTAAATGCCAGT       GGTTATGTAGTAGACAGGCCTCAAATTAATGGGAAATACATATTGCAATGACATGGCACCTTAGTCAT       TAAAGAAGCAACAGCTTATGACAGAGGAAACTATATCTGTAAGGCTCAAATAAGTGTTGGTCATACAC       AGTCACCAGGACAGGGGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAGCCAGAAATCAC       GTGGGAGATGCCTGACCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAGTGAGCAAGC       TTCACTTACAAGGTACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACA       GCAAAGAACCCACTTGGTAGTGATTATGCAGCAACGTATATTCAAGTAATCCTCGAGGGC                                         NOV29, 248210155   SEQ ID NO:684   473 aa   MW at 52119.3 kD           Protein Sequence                     TLEGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD           DTIYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIVVPDNIFLTAPYYGSR       TVHKNGTLEIRNVRLSDSADFICVARNEGGESVLWQLEVLEMLRRPTFRIAAPFNEKIVAQLGKSTAL       NCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAG1ARCAARNKVGYIEKLVI       LEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVI       KEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEIT       WEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVILEG                                     NOV29k, 248213764   SEQ ID NO:685   1372 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       C ACCCTCGAGGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGT           GGAGGTTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGTACACATTTCATGCCAATGGGTCTTTG       ACCATCAACAAAGTGAAACTGCTCGAATTCTGGAAGAGTACGTATGTGTAGCCCGATCCCAGTGGGGA       TGACACCAAAATGTACAAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTCTGTATACAAACA       GAACTGTTATTAAAGCCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACA       CCATCTCCTGAAGTCATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAG       AATCACAGTCCATAAAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTA       TCTGTGTGGCCCGAAATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTG       AGAAGACCGACATTTAGAAATCCAATTTAAATGAAATAAAGTTGCCCAGCTAGA3AGTCCACAGCATT       GAATTGCTCTGTTGATGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATGGCACACGATTTT       CCAATGGACCACAAAGTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTAATCATTTCTAAAACACT       CGGGAGGATGCAGGAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAAAATTAGTCAT       ATTAGAATTGGCCAGAAGCCAGTTATTCTTACCTATGCACCAAGGGACAGTAAAAGGCATCAGTGGAG       AATCTCTATCACTGCATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGT       GGTTATGTAGTAGACAGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCAT       TAAAGAAGCAACAGCTTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACAC       TGATTACTGTTCCAGTAATGATTGTAGCCTACCCTCCCCGAATTACATCGTCCACCCAAGGAAGTATT       GTCACCAGGACAGGGGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCAC       ATGGGAGATGCCTGACCACTCCCTTCTCTCACGGCAAGTAAAGAGAGGACACATCGAAGTGAAGCAGC       TTCACTTACAAGGTACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACA       GCACTCGAGGGC                                         NOV29k, 248213764   SEQ ID NO:686   457 aa   MW at 50532.6 kD           Protein Sequence                     TLEGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD           DTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHHSKKHFDCRAGTPSPEVMWIMPDNIFLTAPYYGSR       ITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFPNPFNEKIVAQLGKSTAL       NCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVI       LEIGQKPVILTYAPGTVKGISGESLSLHcVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVI       KEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEIT       WEMPDHSLLSTASKERTHRSEQLHLQGTLVIQNPQTSDSGIYKCTALEG                                     NOV29l, 248213768   SEQ ID NO:687   1383 bP           DNA Sequence   ORF Start: at 2   ORF Stop: at 1382                       C ACCCTCGAGGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGT           GGAGGTTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGTACACATTTCATGCCAATGGGTCTTTG       ACCATCAACAAAGTGAAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGA       TGACACCAAATGTACAAACTGGAATGTGGTCTCTAAACCTCCATTAATCAAATGGTCTGTAATACATA       GAACTGTTATTAAAGCCACAGCTGTGAGACATTCCAAAAACACTTTGACTGCAGAGCTGAAAGGGACA       CCATCTCCTGAAGTCATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAG       AATCACAGTCCATAAAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTA       TCTGTGTGGCCCGAAATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTG       AGAAGACCGACATTTAGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATT       GAATTGCTCTGTTGATGGTAACCCACCACCGGAAATMATCTGGATTTTACCAAATGGCACACGATTTT       CCAATGGACCACAAGTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTAATCATTTCTAAACAAACT       CGGGAGGATGCAGGAAAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCAT       ATTAGAAATTGGCCAGAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAG       AATCTCTATCACTGCATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGT       GGTTATGTAGTAGACAGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCAT       TAAAGAAGCAACAGCTTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACAC       TGATTACTGTTCCAGTAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATT       GTCACCAGGACAGGGGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCAC       GTGGGAGATGCCTGACCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGC       TTCACTTACAAGGTACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACA       GCACTCGAGGGCAAGGGCGAATC                                         NOV29l, 248213768   SEQ ID NO:688   460 aa   MW at 50747.8 kD                         TLEGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD           DTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSR       ITVHKNGTLEIRNLVRLSDSADFICVAPNEGGESVLWQLEVLEMLRRPTFRNPFNEKIVAQLGKSTAL       NCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVI       LEIGQKPVILTYAPGTVKGISGESLSLHVSDGIPKPNIKWTMPSGYAATDRPQINGKYILHDNGTLVI       KEATAYDRGNYICKAQNSVGHTLITVPVAMVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEIT       WEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTALEGKGE                                     NOV29m, 248213772   SEQ ID NO:689   1372 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       C ACCCTCGAGGGGGACAAAATTACTACTGAAACTGCTCAGCCACTGGGGAGCCCACCCCAAATAATGT           GGAGGTTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGTACACATTTCATGCCAATGGGTCGTTG       ACCATCAACAAAGTGAAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGA       GAACTGTTATTAAAGCCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACA       CCATCTCCTGAAGTCATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAG       AATCACAGTCCATAAAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTA       TCTGTGTGGCCCGAAATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTG       AGAAGACCGACATTTAGAAATCCATTTAATGAAAAAATAGTTGcCCAGCTGGGAAAAGTCCACAGATT       GAATTGCTCTGTTGATGGTAACCCACCACCGGAAATAATCTGGATTTTACCAAATGGCACACGATTTT       CCAATGGACCACAAAGTTATCAGTATCTGATAGCAAGCAATGATTCTTTTATCATTTCTAAAACAACT       CGGGAGGATGCAGGAAAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCAT       ATTAGAAATTGGCCAGAAGCCAGTTATTCTTACCTATGCAACCAGGGACAGTAAAGAATCAAGTGGAG       AATCTCTATCACTGCATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAATGGACTATGCCAAAGT       GGTTATGTAGTAGACAGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCAT       TAAAGAAGCAACAGCTTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACAC       TGATTACTGTTCCAGTAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATT       GTCACCAGGACAGGGGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAAGCCAGAATCAC       TTCACTTACAAGGTACCCTAGTCATTCAGAATCCCCAACCTCCGATTCTGGGATATACATGCACA       GCACTCGAGGGC                                         NOV29m, 248213772   SEQ ID NO:690   457 aa   MW at 50433.5 kD           Protein Sequence                     TLEGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRYTFGSLTINKKAKAALDSGEYVCVAPANPSGD           DTKMAYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCAGTPSPEVMWIMPDNIFLTAAPYYGSR       ITVKKNGTLEIRNVRISDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTAL       NCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVI       LEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVI       IWEMPDHSLLSTASKERTHGSEQLHLQGTLVTQNPQTSDSGTYKCTALEG                                     NOV29n, 248586774   SEQ ID NO:691   1420 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       C ACCCTCGAGGGGGACAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCCCCCAAAAAAATAATGT           GGAGGTTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGTACACATTTCATGCCAATGGGTCTTTG       ACCAATCAACAAAGTGAAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAATCCCAGTGGGGA       TGACAACCAAATGTACAAACTGGAATGTGGTCTCTAAACCTCCAATTAAATCATGGTCTGTATACATA       GAACTGTTATTAAAGCCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACA       AATCACAGTCCATAAAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTA       TCTGTGTGGCCCGAAAATGAAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGATGCTG       AGAAGACCGACATTTAGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATT       GAATTGCTCTGTTGATGGTAAACCCACCACCTGAAATAATCTGGATTTTACCAATGGCACACGATTTT       CCAATGGACCACAAAGTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATTTCTAAAACAACT       CGGGAGGATGCAGGAAAAATATCGCTGTGCAGCTAGGAATAAGTTGGCTATATTGAGAAATTAGTCAT       ATTAGAAATTGGCCAGAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAG       ATCTCTATCACTGCATTGTGTGTCTGATGGAATCCCTAAGCCAPAATATCAAATGGACTATGCCAAGT       GGTTATGTAGTAGACAGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCAT       TAAAGAAGCAACAGCTTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACAC       TGATTACTGTTCCAGTAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATT       GTCACCAGGACAGGGGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCAC       GTGGGAGATGCCTGACCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGC       TTCACTTACAAGGTACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACA       GCAAAGAACCCACTTGGTAGTGATTATGCAGCAACGTATATTCAAGTAATCCTCGAGGGC                                         NOV29n, 248586774   SEQ ID NO:692   473aa   MW at 52168.4 kD           Protein Sequence                     TLEGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD           DTKMYKLDVVVSKPPLINGLYTNRTVIKATAVPASKAFDCFAAGTPSPEVMWIMPDNIFLTAPYYGSR       ITVHKNGTLEIRVRLSDSADFICVAR1AIEGGESVLVVQLEVLEMLRKPTFRNPFNEIVAQLGKSTAL       INCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDGKYRCAARNKVGYIEKLVI       LEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVI       KEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEIT       WEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVILEG                                     NOV29o, 248586793   SEQ ID NO:693   1420 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       C ACCCTCGAGGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGT           GGAGGTTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGTACACATTTCATGCCAATGGGTCGTTG       ACCATCAACAAAGTGAAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGA       TGACACCAAAATGTACAACTGGATGTGGTCTCTAACCTCCATTAATCAATGGTCTGTATACCAAAACA       GAACTGTTATTAAAGCCACAGCTATGAGACATTCCAPAAACACTTTGACTGCAGAGCTGAAGGGAACA       CCATCTCCTGAAGTCATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAG       AATCACAGTCCATAAAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTA       TCTGTGTGGCCCGATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGATACTGGAAAATGCTG       AGAAGACCGACATTTAGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATT       GAATTGCTCTGTTGATGGTAACCCACCACCGGAAATAATCTGGATTTTACCAAATGGCACACGATTTT       CCAATGGACCACAAAGTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATTTCTAAAACAACT       CGGGAGGATGCAGGAAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAAAGAATTAGTCAT       ATTAGAAATTGGCCAGAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAGGCATCAAGTGGAAG       AATCTCTATCACTGCATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGT       GGTTATGTAGTAGACAGGCCTCAAATTAATGGGAAATACATATTGCATGACATGGCACCTTAGTCAAT       TAAAGAAGCAACAGCTTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACAC       TGATTACTGTTCCAGTAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATT       GTCACCAGGACAGGGGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAGCCAGAAATCAAC       GTGGGAGATGCCTGACCACTGGGTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGC       TTCACTTACAAGGTACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTAGATAATACAAATGCACA       GCAAAGAACCCACTTGGTAGTGATTATGCAGCAACGTATATTCAAGTAATCCTCGAGGGC                                         NOV29o, 248586793   SEQ ID NO:694   473 aa   MW at 52200.5 kD           Protein Sequence                     TLEGDKLLLNCSATGEPKPQIMWRTLPSKAVVDQQHRYTFHANGSLTINKVKLLDSGEYVCVARPSGD           DTKMYKLDVVSKPPLINGLYTNRTVIKATAMRHSKKIFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSR       ITVHNGTLEIRNKTRLSDSADFICVARNEGGESVLVQLEVLEMLRRPTFRIAPFNEKIVAQLGKSTAL       NCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVI       LEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVI       KEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEIT       WEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVILEG                                     NOV29p, 248586820   SEQ ID NO:695   1420 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       C ACCCTCGAGGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGT           ACCATCAACAAAGTGAAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGA       GAACTGTTATTAAAGCCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACA       CCATCTCCTGAGTCATGTGGATCATGCCAGACATATTTTCCTCACAGCCCCAATAACTATGGAAGCAG       AATCACAGTCCATATATGGAACCTTGGAATTAGGAATGTGAGGCTTTCAGAATTCAAGCCGAACTTTA       TCTGTGTGGCCCGAAATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTG       AGAAGACCGGCATTTAGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATT       GAATTGCTCTGTTGATGGTAACCCACCACCGGAAATAATCTGGATTTTACCAAATGGCACACGATTTT       CGGGAGGATGCAGGAAAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCAT       ATTAGAAATTGGCCAGAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAG       AATCTCTATCACTGCATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGT       TAAAGAAGCAACAGCTTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACAC       TGATTACTGTTCCAGTAATGATTGTAGCCTACCCTCCCCGATTACAATCGTCCACCCAGGAGTAAATT       GTCACCAGGACAGGGGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCAC       GTGGGAGATGCCTGACCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGC       TTCACTTACAAGGTACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACA                                         NOV29p, 248586820   SEQ ID NO:696   473 aa   MW at 52169.4 kD           Protein Sequence                     TLEGDKLLLNCSATGEPKPQIMWRLQSKAVVDQQHRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD           DTKMYKLDVVSKPPLINGLYTNRTVIKATAVAATSKKHFDCPAGTPSPEVMWIMPDNIFLTAPYYGSR       ITVHKNGTLEIRNVRLSDSADFICVARIAIEGGESVLWQLEVLEMLRRPFRNPFNEKIVAQLGKSTAL       NCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVI       LEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVI       KEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEIT       WEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVILEG                                     NOV29q, 248586824   SEQ ID NO:697   1420 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                     CACCCTCGAGGGGGACAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAAAACACCAATAATGT           GGAGGTTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGTACACATTTCATGCCAATAAGTCTTTG       ACCATCAACAAAGTGAAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAATCCCAAGTGGGGA       GAACTGTTATTAAAGCCACAGCTGTGAAGACAAATTCCAACAACTTTGAAACTGCAGAAATGAAGACA       CCATCTCCTGAAGTCATGTGGATCAATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAGCAG       AATCACAGTCCATAAAAAAATGGAACCTTGGATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTA       AGAAGACCGACATTTAGAAAATCCAATTTAATGAAAAAATAGTTGCCCAGCTGGGAGTCCACAGCATT       GATTGCTCTGTTGATGGTAACCCACCAAACCTGAAAAATCTGGATTTTACCAAATGGCACACGATTTT       CCAATGGACCACAAAGTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATTTCTAAACAAACT       CGGGAGGATGCAGGAATATCGCTGTGCAGCTAGGAATAAGTTGGCTAAATAAATTGAGATTAAGTAAT       ATTAGAAATTGGCCAGAAGCCAGTTATTCTTACCTATGCACCAGGGACAAGTAAAGGCATCAGTGGAG       GGTTATGTAGTAGACAGGCCTCAATTAATGGGAATACATATTGACATGACAAATGGCACCTTAGTCAT       TAAAGAAGCAACAGCTTATGACAGAGGAAACTATATATGTAAGGCTCAAAATAGTGTTGGTCATACAC       TGATTACTGTTCCAGTAATGATTGTAGCCTACCCTCCCCGAAATTACAATCGTCCACCCAGGAGTATT       GTCACCAGGACAGGGGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAAGCCAGAATCAC       GTGGGAGATGTCTGACCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGC       GCAAAGAACCCACTTGGTAGTGATTATGCAGCAACGTATATTCAAGTAATCCTCGAGGGC                                         NOV29q, 248586824   SEQ ID NO:698   473 aa   MW at 52198.4 kD           Protein Sequence                     TLEGDKLLLNCSATGEPKHQIMWRLPSKAVVDQQHRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD           ITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTAL       INCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLISNGSFIISKTTREDAGKYRCAARNKVGYIEKLVI       LEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVI       KEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEIT       WEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVILEG                                     NOV29r, 247679817   SEQ ID NO:699   635 bP           DNA Sequence   ORF Start: at 3   ORF Stop: end of Sequence                       AG CTCCGCGGCCGCCCCCTTCACCCTCGAGTGTCCTCGCCGCTGTGCCCTGTTATATGCACCCTCGAG           TGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCACATTTCGGTACCTGACTTCCAT       CCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGATACAACAGCTTGGTTAGATTGATGG       CCTGACAAGACCTTCTCAGATTTGCAAAGGCCTTGCAAGGTCTTAAATGAAGCTATAACAAAGTCAAA       ACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCTTGACACGATTGCACATGGACCACAACAATATTG       AGTTTATACCCAAGAAAGGTTTTTGAAAAGGGCTCAACTTTCTCCGCCTGGTGCACTTGGAGGATCAG       CTCACTAAGCTCCACCCAGATACAAATTTGTCTCTTTGAGCTACCTCCAGATATTTAATCTCTTTCAT       TAAGTTCCTATACTTGTCTGATAACTTCCTGACCTCCCTCCCTCAAGAGATGGTCTCCTATATGCCTC       TCGAGGGCAAGGGTGGGCGCGCC                                         NOV29r, 247679817   SEQ ID NO:700   211 aa   MW at 24064.7 kD           Protein Sequence                     APRPPPSPSSVLAAVPVICTLEPPACACYMPTEKAACTFRYLTSIPDSIPPNVERINLGYNSLVRLME           TDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIE       FINPEVFDGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYMPL       EGKGGRA                                     NOV29s, 248210264   SEQ ID NO:701   646 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       A ACCCTCGAGATGAAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCC           TGGTCGCCACCCCTGGGGGCAAGGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACAC       TGCACATTTCGGTACCTGACTTCCATCCCAGACAGCATCCCGCCCA1ATGTGGAACGCATCATTTAGG       ATACAACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGC       TTCACAGCAATGGCATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGcAGGTCTTA       AAAATGAGCTATAACAAAGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCTTGACACG       ATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAACTTTCTCC       GCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTTGAGCTAC       CTCCAGATATTTAAAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCTCCCTCCC       TCAAGAGATGGTCTCCTATATGCCTCTCGAGGGC                                         NOV29s, 248210264   SEQ ID NO:702   215 aa   MW at 24618.6 kD           Protein Sequence                     ATLENKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPEVHCTFRYLTSIPDSIPPNVERINLG           YNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTR       LHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQTFKISFIKFLYLSDNFLTSLP       QEMVSYMPLEG                                     NOV29t, 248210551   SEQ ID NO:703   646 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       C ACCCTCGAGATGAAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCC           TGGTCGCCACCCCTGGGGGCAAGGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACAC       TGCACATTTCGGTACCTGACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGG       ATACAACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGC       TTCACAGCAATGGCATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTCTTA       AATGAGCTATAAACAAAAGTCCGAAACTTCAGAAAAGATACTTTTTATGGCCTCAGGAGCTTGACACG       ATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAACTTTCTCC       GCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTTGAGCTAC       CTCCAGATATTTAAAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCTCCCTCCC       TCAAGAGATGGTCTCCTATATGCCTCTCGAGGGC                                         NOV29t, 248210551   SEQ ID NO:704   215 aa   MW at 24618.6 kD           Protein Sequence                     TLEMKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLG           YNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTR       LHMDHNNEFINPEVFYGLIAFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLP       QEMVSYMPLEG                                     NOV29u, 248210824   SEQ ID NO:705   646 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       C ACCCTCGAGATGAAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCC           TGGTCGCCACCCCTGGGGGCAAGGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACAC       TGCACATTTCGGTACCTGACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGG       TTCACAGCAATGGCATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTCTTA       AAAATGAGCTATAACAAAGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCTTGACACG       ATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAACTTTCTCC       GCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTTGAGCTAC       CTCCAGATATTTAATCTCTTTCATTAGTTCCTATACTTGTCTGAT1AAACTTCCTGACCTCCCTCCC       TCAAGAGATGGTCTCCTATATGCCTCTCGAGGGC                                         NOV29u, 248210824   SEQ ID NO:706   215 aa   MW at 24618.6 kD           Protein Sequence                     TLEMKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLG           YNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTR       LHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLP       QEMVSYMPLEG                                     NOV29v, 248679541   SEQ ID NO:707   646 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       C ACCCTCGAGATGAAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCC           TGGTCGCCACCCCTGGGGGCAAGGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACAC       TGCACATTTCGGTACCTGACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGG       ATACAACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGC       TTCACAGCAATGGCATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTCTTA       AAAATGAGCTATAACAAAGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCTTGACACG       ATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAACTTTCTCC       GCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTTGAGCTAC       CTCCAGATATTTAAAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCTCCCTCCC       TCAAGAGATGGTCTCCTATATGCCTCTCGAGGA                                         NOV29v, 248679541   SEQ ID NO:708   215 aa   MW at 24618.6 kD           Protein Sequence                     TLEMKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLG           YNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTR       LHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLP       QEMVSYMPLEG                                     NOV29w, 247679454   SEQ ID NO:709   2011 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       A GGCTCCGCGGCCGCCCCCTTCACCCTCGAGGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGG           AGCCCAAACCCCAAATAATGTGGAGGTTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGAGTGGGC       AGCTGGATCCACGTCTACCCTAATGGATCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGT       CTACTTGTGTGTGGCAAGAAACAAAATGGGGGATGATCTGATACTGATGCATGTTAGCCTAGAACTGA       AACCTGCCAAAATTGACCACAAGCAGTATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTA       GATTGCAAGCTTCCGGCTCCCCAGTGCCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAAA       TATACTTCAACAAAGTTGGGGTAGCGGAGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGG       AAAGATGAAATGAAGGTCCACTTAACAGTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAAC       AATGGGTCTTTGACCATCAACAAAGTGAAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAA       TGTATACAAATAGAACTGTTATTAAAGCCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGA       GCTGAAGGGACACCATCTCCTGAAGTCATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATA       CTATGGAAGCAGAATCACAGTCCATAAAAATGGAACCTTGGAAATTAGGTATGTGAGGCTTTCAGATT       GTCCACAGCATTGAATTGCTCTGTTGATGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATG       GCACACGATTTTCCAATGGAACCACAAGTTATCAGTATCTGAATAGCAGCAATGGTTCTTTTATCATT       TCTAAAACAACTCGGGAGGATGCAGGAAAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGA       GAAATTAGTCATATTAGAAATTGGCCAGAAGCCAGTTATTCTTACCTATGCAACCAAGGGACAGTAAG       CATCAGTGGAGAATCTCTATCACTGCATTGTGTGTCTGATGGAATCCCTAAAGCCAAATATCAAATGG       AACTATGCCAAGTGGTTATGTAGTAGACAGGCCTCAAATTAATGGGAATACATATTGCATGACAATGG       ACCTTAGTCATTAAAGAAGCAACAGCTTATGACAGAGGAAACTATAATCTGTAAGGCTCAAAATAGTG       TGGTCATACACTGATTACTGTTCCAGTAATGATTGTAGCCTACCCTCCCCGAATTACAAAATCGTCCA       CCCAGGAGTATTGTCACCAGGACAGGGGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAA       GCCAGAAATCACGTGGGAGATGCCTGACCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATG       GAAGTGAGCAGCTTCACTTACAAGGTACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATA       TACAAATGCACAGCACTCGAGGGCAAGGGTGGGCGCGCC                                         NOV29w, 247679454   SEQ ID NO:710   670 aa   MW at 74046.2 kD           Protein Sequence                     GSAAAPFTLEGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGV           NAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDENKVHLTVITAAPRIRQSNKT       NKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARN       PSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPY       YGSRITVHKNGTLEIRYVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGK       STALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIE       IKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNKWTMPSGYVVDRPQINGKYILHDNG       TLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPK       PEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTMAEGKGGRA                                     NOV29x, 314361407   SEQ ID NO:711   2902 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       C ACCCTCGAGAACTCAGATGCCTTTCTTCCCTGTGAAGCTGTTGGAAATCCCCTGCCCACCATTCATT           GGACCAGAGTCCCATCAGGACTTGATTTATCTAAAGAGGAACAGAATAGCAGGGTCCAGGTTCTCCCC       AATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAA       TCTGTTTGGCACAGACCACCTTCATGTCACCTTGTCTGTGGTTTCCTATCCTCCCAGGATCCTGGAGA       GACGTAACCAAGAGATCACAGTTCATTCCGGAAGCACTGTGGAACTGAAGTGCAGAGCAGAAGGTAGG       CCAAGCCCTACAGTTACCTGGATTCTTGCAAACCAAACAGTTGTCTCAGAATCATCCCAGGGAAGTAG       GCAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTATGACCGTGGCTTTT       ACAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAAATACAAGTCATTGCAGCA       CCACCTGTTAATTCTAAAGAGCAAGGAGGCAAGTCATTGTAGGCACTTGGGGTGAAAGTTTAACTGCC       CTGTACTGCAAAAGGAACTCCTCAGCCCAGCGTTTACTGGGTCCTCTCTGATGGCACTGAAGTGAAAC       CATTACAGTTTACCAATTCCAAAGTTGTTCTTATTTTCAAATGGGACTTTGTATATAAGAACCTAGCC       TCTTCAGACAGGGGCACTTATGAATGCATTGCTACCAGTTCCACTGGTTCGGAGCGAGAGTAGTAAAT       ATTTTGGGGACAATTACTACTGAAACTGCTCAAGCCACTGGGGAGCCCAAACCCCAAATATGTGGAGG       TTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGAGTGGGCAGCTGGATCCACGTCTAACCCTATGG       TGGGGGATGATCTGATACTGATGCATGTTAAGCCTAAGACTGACCTGCCAAATTGAACCAAACAGCAG       TATTTTAGAAAGCAAGTGCTCCATGGGAAAGAATTTCCAAGTAGATTGCAAGCTTCCGGCTCCCCAGT       GCCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTTTATACTTCAACAAAGTTGGGGTAGCG       GAGGAAGGAGATTATACTTGCTATGCCCAGAACAACCCTAGGGAAGAATGATGAAAGGTCCAACTTAC       AGTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAAACCAACAAAGAGAATCAGCTGGAGACA       CAGCTGTCCTTGACTGTGAGGTCACTGGGGATCCCAACCAAAATATTTTGGTTGCTGCCTTCCATAAT       GACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCCATGGGTCTTTGACCATCAAACAAAGT       GAAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGATGACACCAAAATGT       ACAAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTCTGTATACAAATAGAACTGTTATTAAA       CATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAGAATCACAGTCCATA       AAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTATCTGTGTGGCCCGA       AATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGAAAATGCTGAGAAGACCGACATT       TAGAAATCCATTTAATGAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATTGAAATTGCTCTGTTG       AAAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCATATTAGAAATTGGCC       AGAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAGATCTCTATCAACTG       CATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAGTGGTTATGTAGTAAGA       CAGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCATTAAAGAAGCAACAG       CTTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACACTGATTACTGTTCCA       GTAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATTGTCACCAGGACAGG       GGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCACGTGGGAGATGCCTG       ACCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGCTTCACTTACAAGGT       ACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACAGCAAAGAACCCACT       TGGTAGTGATTATGCAGCAACGTATATTCAAGTAATCCTCGAGGGC                                         NOV29x, 314361407   SEQ ID NO:712   967 aa   MW at 106911.3 kD           Protein Sequence                     TLENSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASN           QAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLP       CTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVM       LTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNG       SLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPV       PEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLT       VITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKV       KLLDSGEYVCVARNPSGDDTAMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEV       MWIMPDNIFLTAPYYGSRITVHKNGTLEIRAVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTF       RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAG       KYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVD       RPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTG       AAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKAPL       GSDYAATYIQVILEG                                     NOV29y, 317803448   SEQ ID NO:713   2902 bP           DNA Sequence   ORF Start: at 2   ORF Stop: end of Sequence                       C ACCAGATCTAACTCAGATGCCTTTCTTCCCTGTGAAGCTGTTGGAAATCCCCTGCCCACCATTCATT           GGACCAGAGTCCCATCAGGACTTGATTTATCTAAGAGGAAACAGAATAGCAGGGTCCAGGTTCTCCCC       AATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAA       TCTGTTTGGCACAGACCACCTTCATGTCACCTTGTCTGTGGTTTCCTATCCTCCCAGGATCCTGGAGA       GACGTACCAAGAGATCACAGTTCATTCCGGAGCACTGTGGAAACTGAAGTGCAGAAGCAGAGGTAAGG       GCAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAAATCTCAGTATTTATGACCGTGATTTT       ACAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAATACAAAGTCATTGCAGCA       TCTTCAGACAGGGGCACTTATGAATGCATTGCTACCAGTTCCACTGGTTCAAGCGAAGAGTAGTAAAT       GCTTACAATGGAAGAGCGAGTGACCAGCCCCAAGGATAGAAGCTGCAATCCCAGAGGAAACTGAGTGA       ATTTTGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGTGGAGG       TTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGAGTGGGCAGCTGGATCCACGTCTACCCTAATGG       TATTTTAGAAAGCAAAAGTGCTCCATGGGAAAGATTTCCAAGTAGATTGCAGCTTCCGGCTCCCCAGT       GAGGAAGGAAGAAATTATACTTGCTATGCCCAAAAGAACACCCTAGGGAAGATGTGAGGTCCACTTAC       AGTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAACCAACAAGAGAATCAAAGCTGGAGACA       GACATGATTTCCTTCTCCATTGATAGGTACACAAAATTTCAATGCCATGGGTCTTTGACCATCACAGT       GAAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAAATCCCAGTGGGGATGACACCAAATGT       GCCACAGCTGTGAGACATTCCMACACTTTGACTGCAGAGCTGAAAAGGGAACAAACCATCTCCTGAGT       AAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTATCTGTGTGGCCCGA       ATGGTAACCCACCACCTGAATAATCTGGATTTTACCATACACAACGATTTTCCAATGGAACCAAACAA       AGTTATCAGTATCTGATAGCAAAGCAAATGGTTCTTTTAATCAAAATTTCTAACACTCGGGACATGCA       AGAAGCCAGTTATTCTTACCTAATGCAACCAAGGGACAGTAAGGCATCAGTGGAGATCTCTATCACTG       CAGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCATTAAAGAAGCAACAG       CTTAATGACAGAGGAAACTATATCTGTAAGGCTCAAATAGTGTTGGTCATACACTGATTACTGTTCCA       GTAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATTGTCACCAGGACAGG       GGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAAGCCAGAAACACGTGGGAGATGCCTG       ACCACTCCCTTCTCTCAACGGCAAGTAAGAGAGGACACATAAGTGAGCAGCTTCACTTACGAATAAAT       ACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGAATATAAATGCAAACAGCAAGAACCCACT       TGGTAGTGATTATGCAGCAACGTATATTCAAGTATCCTCGAGGGC                                         NOV29y, 317803448   SEQ ID NO:714   967 aa   MW at 106912.3 kD           Protein Sequence                     TRSNSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRAEIQDRGQYLCSASN           LFGTDHLHTLSVVSYPPRILERRATKEITVHSGSTVELKCPGRPSPTVTVVIAAAAQTVVSESSQGSR       QAVATVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLP       CTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIPNAASSDRGTYECIATSSTGSERRVVM       LTMEERVTSPRIEAAASQKATEVNFGDKLLLNCSATGEPKPQIMIPSAWDQQHRVGSWIHVYAAYPNG       SLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPV       PEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLT       VITAAPRTRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKV       MWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTF       RNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAG       KYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVD       RPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVVGHTLITVPVMIVAYPPRITAPPRSIVTRTG       AAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPL       GSDYAATYIQVILEG                                     NOV29z, CG55776-02   SEQ ID NO:715   7831 bP           DNA Sequence   ORF Start: ATG at 6   ORF Stop: TGA at 7812                       TCAGG   ATG AAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCCTGGTC           GCCACCCCTGGGGGCAAGGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCAC       ACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCAC       AGCAATGGCATTCACACAATCCCTGACAAAGACCTTCTCAGATTTGCAGGCCTTGCAATGAGACTGAT       GGTCTTAAAAATGAGCTATAATAAAGTCCGAAAAACTTCAGAAGATACTTTTTATGGCCTCAGGAGCT       TGACACGATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAAC       TTTCTCCGCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTT       GAGCTACCTCCAGATATTTAAAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCT       CCCTCCCTCAAGAGATGGTCTCCTATATGCCTGACCTAGACAAAGCCTTTACCTGCATGGACCCATGG       ACCTGTGATTGCCATTTAAAGTGGTTGTCTGACTGGATACAGGAGAAGCCAGGTATCTATATTGTTTT       ACCAGATGTAATAATGCAAAAAGATAGAAGTCCCTCTAGTGCTCAAAGCAAGTGTCCAACTTTAATGA       ACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTGCAGCTTTCCAGTGTGCCAAGCCA       ACCATTGACTCATCCCTGAAATCAAAGAGCCTGACTATTCTGGAAGACAGTAGTTCTGCTTTCATCTC       TACATCGTGCTAAATACTTCATTTTCAACATTTTTGGTGTGCAACATAGATTACGGTCACATTCAGCC       AGTGTGGCAAATTTTGGCTTTGTACAGTGATTCTCCTCTGATACTAGAAAGGAGCCACTTGCTTAGTG       GAGGCAAAGATCTCAAGAAGCAGATCCCTCTTGGTTATGCAGACCTTTCCTTGCAAGCTGAAACAGAC       TGCCACCACATTCAGTACATTACAGATCCAGTACTCCAGTGATGCTCAAATCACTTTACCAAGAGCAG       GTCTTGGTAGGTGGACCGTTGGCCTGAACTGCCCAGGCCAGGAGACCCCACCCCAACACGTGGAATTG       GCTTCTAGCTGATGGAAGTAGTGAGAGCCCCTTATGTCAGTGAGGATGGACAATCCTAAATAAGAACA       AAAGTGGAAAATTGGAACTCCAGATGGCTGATAGTTTTGACACAGGCGTATATCACTGTATAAGCAGC       ATTATGATGATGCAGATATTCTCACCTATAGGATACTGTGGTAAGAAACCTTTGGTCGAGCCTAATCA       GGAAAATGGGATTCATCACACAGTTTTCATTGGTGAAACACTTGATCTTCCATGCCATTCTACTGGTA       AAAGTTCTAAACAATGGCACATTAAGAATATTACAGGTCACCCCGAAAGACCAAGGTTATTATCGCTG       TGTGGCAGCCAACCCATCAGGGGTTGATTTTTTGATTTTCCAAGTTTCAGTCA7AGATGAGGACAAAA       GGCCCTTGGAGCATGATGGAGAAACAGAGGGATCTGGACTTGATGAGTCCAATCCTATTGCTCATCTT       AAGGAGCCACCAGGTGCACAACTCCGTACATCTGCTCTGATGGAGGCTGAGGTTGGAAAACACACCTC       AAGCACAAGTAAGAGGCACAACTATCGGGAATTAACACTCCAGCGACGTGGAGATTCAACACATCGAC       GTTTTAGGGAGAATAGGAGGCATTTCCCTCCCTCTGCTAGGAGAATTGACCCACAACATTGGGCGGCA       CTGTTGGAGAAAGCTAAAAAGAATGCTATGCCAGACAAGCGAGAAAATACCACAGTGAGCCCACCCCC       AGTGGTCACCCAACTCCCAAACATACCTGGTGAAGAAGACGATTCCTCAGGCATGCTCGCTCTACATG       AGGAATTTATGGTCCCGGCCACTAAAGCTTTGAACCTTCCAGCAAGGACAGTGACTGCTGACTCCAGA       ACAATATCTGATAGTCCTATGACAAACATAAATTATGGCACAGAATTCTCTCCTGTTGTGAATTCACA       AATACTACCACCTGAAGAACCCACAGATTTCAAACTGTCTACTGCTATTAAAACTACAGCCATGTCAA       AGAATATAAACCCAACCATGTCAAGCCAAATACAAGGCACAACCAATCAACATTCATCCACTGTCTTT       AAGTAGACCCCCAATAACAGTAAGGACTATGATCAAAGATGTCAATGTCAAAATGCTTAGTAGCACCA       GAACCCAGGCACAATCACTTCTATTCTCACACTACTCAAATACTTAGCACCTCCACGTTCCCTTCAGA       TCCACACACAGCTGCTCATTCTCAGTTTCCGATCCCTAGAAATAGTACAGTTAACATCCCGCTGTTCA       GACGCTTTGGGAGGCAGAGGAAAATTGGCGGAAGGGGGCGGATTATCAGCCCATATAGAACTCCAGTT       CTGCGACGGCATAGATACAGCATTTTCAGGTCAACAACCAGAGGTTCTTCTGAAAAAAGCACTACTGC       ATTCTCAGCCACAGTGCTCAATGTGACATGTCTGTCCTGTCTTCCCAGGGAGAGGCTCACCACTGCCA       CAGCAGCATTGTCTTTTCCAAGTGCTGCTCCCATCACCTTCCCCAAAGCTGACATTGCTAGAGTCCCA               TCAGAAGAGTCTACAACTCTAGTCCAGAATCCACTATTACTACTTGAGAACAAACCCAGTGTAGAGAA       AACAACACCCACAATAAAATATTTCAGGACTGAAATTTCCCAAGTGACTCCAACTGGTGCAGTCATGA       CATATGCTCCAACATCCATACCCATGGAAAAAACTCACAAAGTAAACGCCAGTTACCCACGTGTGTCT       AGCACCAATGAAGCTAAAAGAGATTCAGTGATTACATCGTCACTTTCAGGTGCTATCACCAAGCCACC       AATGACTATTATAGCCATTACAAGGTTTTCAAGAAAGGAAATTCCCTGGCAAACAGAAACTTTGTATA       ACCATAACCCAAAGGCAGATTAAGGAATCAACATAAAGTTAAAGTTTACAAAAAGCACAGCTGTGATG       CTTCCTAAACATCTCCTGCTTTACCACAAGAGACAAAGTCTCCCCTCGCACCACACTACGACCAAAAC       ACACAATCCTGGAAGTCTTCCAACAAAGAAGGAGCTTCCCTTCCCACCCCTTAACCCTATGCTTCCTA       GTATTATAAGCAAAGACTCAAGTACAAAAAGCATCATATCAACGCAAACAGCAATACCAGCAACAACT       AAGAGAACAGGAGCCTCAAAAGAAGAACAGGACTGACCCAAACATCTCTCCAGACCAGAGTTCTGGCT       TCACTACACCCACTGCTATGACACCTCCTGTTCTAACCACAGCCGAAACTTCAGTCAAGCCCAGTGTC       AACTCTTAATCTGACAGATGTGATTGAGAACTAGCCCAAGCAAGTACTCAAGACTTTGAAGAGCACAA       CACTCAACCATACCACCATTCTTGAGCAGCAGTGCTACTCTAATGCCAGTTCCCATCTCCCCTCCCTT       TACTCAGAGAGCAGTTACTGACAACGTGGCGACTCCCATTTCCGGGCTTATGACAAATACAGTGGTCA       AGCTGCACGAATCCTCAAGGCACAATGCTACCACAGCATTAGTAAGCAGAAGGTTAAAAACATCCCCC       AAGGTTCACCCAATGCCAAGTTCACAATTGGAACCACTCACTTCATCTACTCTAAATCTGTTACATTC       TTGGCTACTACAGGCCTGTCCGAGGCCACCACTCTTGTTTCAGATTGGGAATGGAACAGAGACACAAA       GAAGAGTGACTTTGATAAGAACCAGTTCAAGAAGCAACAACTTCCAAAACTCCTTCCCTTTGACTCTT       CCCATCAGGTATGTCAGGACTTGAATTTAAATCTAAGAGGCAGAAATAGCAAGTCCAGGTTCTCCCCA       ATGGTACCCTGTCCATCCAGAGGGTGGAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAAAT       CTGTTTGGCACAGACCACCTTCATGTCACCTTGTCTGTGGTTTCCTATCCTCCCAGGATCCTGGAGAG       CAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTATGACCGTGGCTTTTA       CAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAAAACAAAGTCATTGCAGCAC       TGTACTGCAAAGGAACTCCTCAAGCCCAAGCGTTTAAACTGGGTCCTCTCTGATGGCACTGAGTGACC       ATTACAGTTTACCATTCCAAGTTGTTCTTAATTTTCAAATGGGAACTTTGAATATAGAAAQCTAGCCT       CTTCAGACAGGGGCACTTATGATGCATTGCTACCAGTTCCAACTGGTTCGGAAGCGAGAGTAAGTATG       CTTACAATGGAAGAGCGAGTGACCAGCCCCAGGTAAGAAGCTGCATCCCAGAAAAGGACTGAAGTGAA       TTTTGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGTGGAGGT       TACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGGTGGGCAGCTGGATCCACGTCTACCCTTATGGA       TCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGTCTACTTGTGTGTGGCAAGAAACAAAAT       GGGGGATGATCTGATACTGATGCATGTTAGCCTAAGACTGACCTGCCAAATTGAACCAACAAGCAAGT       ATTTTAGAAAGCAAGTGCTCCATGGGAAGATTTCCAAGTAGATTGCAAAGCTTCCGGCTCCCCAAGTG       CCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAATGCAAGCCGATGACAGTGG       CCACAGGACTAGGAGATATCCCTTTTCAACAATGGACTTTATACTTCAAACAAAGTTGGGGTAAGCGG       AGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGGAAAGATGAAATGAAGGTCCACTTAACA       GTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAACCAACAAGAGAATCAAAGCTGGAGACAC       AGCTGTCCTTGACCGTGAGGTGACTGGGGATCCCAAACCAAAAATATTTTGGTTGCTGCCTTCCAATG       GGTCTTTGACCATCAAACAAAGTGAAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAATCCC       AGTGGGGATGACACCAAATGTAACAAACTGGAAATGTGGTCTCTACCTCCATTATCAAATGGTCTGTA               TACAAATAGAACTGTTATTAAAGCCACAGCTGTGAAGAACAATTCCAAACACTTTGACTGCAGAGCTG       GGAAGCAGAATCACAGTCCATAAAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGC       CGACTTTATCTGTGTGGCCCGAAATGAAGGTGGAGAGAAGCGTGTTGGTAGTACAGTTAGAGTACTGG       AAATGCTGAGAAGACCGACATTTAGAATCCATTTAATGAAATAAAGTTACCAGCTGGGATAAAAGTCC       ACAGCATTGAATTGCTCTGTTGATGGTACCCACCACCTGTAATCTGGAAATTTTAAACCAAATGGCAC       ACGATTTTCCAATGGACCACAGTTATCAGTATCTGATAGCAGCAATGGTTCTTTTAATCAATTTCTAA       AAACAACTCGGGAGGATGCAGGAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTAATATTGAGAAAA       TTAGTCATATTAGAATTGGCCAGAAGCCAGTTATTCTTACCTATGCAACCAGGGACAGTAAAGGCAAT       TCATACACTGATTACTGTTCCAGTAATGATTGTAGCCTACCCTCCCCGAATTACAATCGTCCAACCCA       TGCCAAGTGGTTATGTAGTAGACAGGCCTCATTATGGGATACATAATTGCATGAAACAATAAACAACC       TTAGTCATTAAAGAAGCAACAGCTTATGACAGAGGAACTATATCTGTA3AGGCTCAAATAAGTGTTGG       TCATACACTGATTACTGTTCCAGTAATGATTGTAGCCTACCCTCCCCGAAATTACATCGTCCAACCCA       GGAGTATTGTCACCAGGACAGGGGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCA       GAAATCACATGGGAGATGCCTGACCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAG       TGAGCAGCTTCACTTACAAGGTACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACA       AATGCACAGCAAAGAACCCACTTGGTAGTGATTATGCAGCAACGTATATTCAAGTAATG TGA   CATGAA         ATAATAAAGTC                                         NOV29z, CG55776-02   SEQ ID NO:716   2602 aa   MW at 288454.2 kD           Protein Sequence                     MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEAHCTFRYLTSIPDSIPPNVERINLGYNS           LVRLMETDFSGLTKLELLMLHSNGIHIPDKTFSDLQALQVRLMVLKMSYNKKTRKLQKDTFYGLRSLT       RLHMDHNNIEFINPEVFYGLNFLRLVAHLEGNQLTKLHPAFVSLSYLQIFKISFIKFLYLSDNFLTSL       PQEASYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPGIYNTAPDVIKCYAADRSPSSAQQCPLCMNP       RTSKGKPLAMKTSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFSPQGFMAPFGSLTLNMTDQSGNEAN       MVCSIQKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPKAWQILAYSDSPLILERSHLLSET       PQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEM       RPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKS       GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP       DASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRP       LEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKAHSSTSKRHNYRELTLQRRGDSTHRRF       RENRRHFPPSARRIDPQBWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEE       FMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKN       INPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTN       KLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRR       FGRQRKIGGRGRIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATA       ALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTY       APTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPWQQNFVNNH       NPKGRLRNQHKVSLQKSTAVMLPKTSPALPQRQSLPSHHTTTKTHNPGSLPTKKELPFPPLNPMLPSI       ISKDSSTKSIISTQTAIPATTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFT       TPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIA       SETTLSSKSHQSTTTRKAIRHSTIPPFLSSSATLMPVPISPPFTQRAKTTDNVATPISGLMTNTVVKL       HESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAEN       QFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLS       RYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGMSGLDLSKRKQNSRVQVLPNG       TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS       PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP       DRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLP       SKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF       RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNNMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE       GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDREVTGDPKPKIFWLLPSNGS       LTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEG       TPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEM       LRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKT       TREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMP       SGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRS       IVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKC       TAKNPLGSDYAATYIQVI                                     NOV29aa, CG55776-03   SEQ ID NO:717   8270 bP           DNA Sequence   ORF Start: ATG at 6   ORF Stop: TGA at 7779                       TCAGG   ATG AAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCCTGGTC           ATTTCGGTACCTGACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGGTACA       ACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCAC       AGCAATGGCATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTGAGACTGAT       GGTCTTAATGAGCTATAATAAAGTCCGAAAACTTCAGAAAGATAACTTTTTAATGGCCTCAAGGAGCT       TGACACGATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAAC       TTTCTCCGCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTT       CCCTCCCTCAAGAGATGGTCTCCTATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGG       ACCTGTGATTGCCATTTAAAGTGGTTGTCTGACTGGATACAGGAGAAGCCAGGTATCTATATTGTNTT       ACCAGATGTAATAAAATGCAAAAAAGATAGAAGTCCCTCTAGTGCTCAGCAGTGTCCACTTTGCATGA       ACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTGCAGCTTTCCAGTGTGCCAAGCCA       ACCATTGACTCATCCCTGAAATCAAAGAGCCTGACTATTCTGGAAGACAGTAGTTCTGCTTTCATCTC       TCCCCAAGGTTTCATGGCACCCTTTGGCTCCCTCACTTTGAATATGACAGATCAGTCTGGAAATGAAG       CTAACATGGTCTGCAGTATTCAAAAGCCCTCAAGGACATCACCCATTGCATTCACTGAAGAAAATGAC       TACATCGTGCTAAATACTTCAATTTTCAACATTTTTGGTGTGCACATAGATTACGGTCACATTCAGCC       AGTGTGGCAAATTTTGGCTTTGTACAGTGATTCTCCTCTGATACTAGAAAGGAGCCACTTGCTTAGTG       AAACACCGCAGCTCTATTACAAATATAAACAGGTGGCTCCTAAGCCTGAAGACATTTTTACCAACATA       GAGGCAGATCTCAGAGCAGATCCCTCTTGGTTAATGCAAGACCAAATTTCCTTGCAGCTGAACAGAAC       TGCCACCACATTCAGTACATTACAGATCCAGTACTCCAGTGATGCTCAAATCACTTTACCAAGAGCAG       AGATGAGGCCAGTGAAACACAAATGGACTATGATTTCAAGGGATAACAATACTAAGCTGGAACATACT       GTCTTGGTAGGTGGAACCGTTGGCCTGAACTGCCCAGGCCAAGGAGACCCCACCCCACACGTGGATTG       GCTTCTAGCTGATGGAGTAAAGTGAGAGCCCCTTATGTCAGTGAGGATGGACGGATCCTAATAGAACA       AAAGTGGAAAATTGGAACTCCAGATGGCTGATAGTTTTGACACAGGCGTATATCACTGTATAAGCAGC       AATTATGATGATGCAGATATTCTCACCTATAGGATAACTGTGGTAGAACCTTTGGTCGAAGCCTATCA       GGAAAATGGGATTCATCACACAGTTTTCATTGGTGAAACACTTGATCTTCCATGCCATTCTACTGGTA       TCCCAGATGCCTCTATTAGCTGGGTTATTCCAGGAAACAATGTGCTCTATCAGTCATCAAGAGACAAG       AAAGTTCTAAACAATGGCACATTAAGAATATTACAGGTCACCCCGAAAGACCAAGGTTATTATCGCTG       TGTGGCAGCCAACCCATCAGGGGTTGATTTTTTGATTTTCCAAGTTCAGTCAAGATGAAAGGAACAAA       GGCCCTTGGAGCATGATGGAGAAACAGAGGGATCTGGACTTGATGAGTCCAATCCTATTGCTCATCTT       AAGGAGCCACCAGGTGCACAACTCCGTACATCTGCTCTGATGGAGGCTGAAGGTTGGAAACAAACCTC       AAGCACAAGTAAGAGGCACAACTATCGGGAATTAACACTCCAGCGACGTGGAGATTCAACACATCGAC       GTTTTAGGGAGAATAGGAGGCATTTCCCTCCCTCTGCTAGGAGAATTGACCCACAACATTGGGCGGCA       CTGTTGGAGAAAGCTAAAAAGAATGCTATGCCAGACAAGCGAGAAAATACCACAGTGAGCCCACCCCC       AGTGGTCACCCAACTCCCAAACATACCTGGTGAAGAAGACGATTCCTCAGGCATGCTCGCTCTACATG       AGGATTTATGGTCCCGGCCACTAAAGCTTTGAACCTTCCAGCAAGGACAAGTGACTGCTGACTCCAGA       ACAATAATCTGATAGTCCTATGACAACATAAATTATGGCACAGAAATTCTCTCCTGTTGTGATTCACA       AATACTACCACCTGAAGAACCCACAGATTTCAAAGTCTCTACTGCTATTAAAACTACAGCCATGTCAA       AGAATATAAACCCAACCATGTCAAGCCAAATACAAGGCACAACCAATCAACATTCATCCACTGTCTTT       CCACTGCTACTTGGAGCAACTGAATTTCAGGACTCTGACCAGATGGGAAGAGGAAGAGAGCATTTCCA       AAGTAGACCCCCAATAACAGTAAGGACTATGATCAGATGTCAATGTCAAAATGCTTAAGTAAGCACCA       CCAACAAACTATTATTAGAGTCAGTAAATACCACAAATAGTCATCAGACATCTGTAAGAGAAGTGAGT       GAACCCAGGCACAATCACTTCTATTCTCACACTACTCAAATACTTAGCACCTCCACGTTCCCTTCAGA       TCCACACACAGCTGCTCATTCTCAGTTTCCGATCCCTAGAAATAGTACAGTTAACATCCCGCTGTTCA       GACGCTTTGGGAGGCAGAGGAAAATTGGCGGAAGGGGGCGGATTATCAGCCCATATAGAACTCCAGTT       CTGCGACGGCATAGATACAGCATTTTCAGGTCAACAACCAGAGGTTCTTCTGAAAAAAGCACTACTGC       ATTCTCAGCCACAGTGCTCAATGTGACATGTCTGTCCTGTCTTCCCAGGGAGAGGCTCACCACTGCCA       CAGCAGCATTGTCTTTTCCAAGTGCTGCTCCCATCACCTTCCCCAAAGCTGACATTGCTAGAGTCCCA               TCAGAAGAGTCTACAACTCTAGTCCAGAATCCACTATTACTACTTGAGAACAAACCCAGTGTAGAGAA       CATATGCTCCAACATCCATACCCATGGAAAAAACTCACAAAGTAAACGCCAGTTACCCACGTGTGTCT       AGCACCAATGAAGCTAAAAGAGATTCAGTGATTACATCGTCACTTTCAGGTGCTATCACCAAGCCACC       ACCATAACCCAAAAGGCAGATTAAAGGAAATCAACAATAAAGTTAGTTTACAAAGCACAGCTGTGATG       CTTCCTAAAACATCTCCTGCTTTACCACAGAGACAAAGTCTCCCCTCGCACCACACTACGACCAAAAC       ACACAATCCTGGAAGTCTTCCAACAAAGAAGGAGCTTCCCTTCCCACCCCTTAACCCTATGCTTCCTA       GTATTATAAGCAAGACTCAAGTAACAAGCAATCAATAATCAACGCAAACAAGCAAATACCAGCACACT       CCTACCTTCCCTGCATCTGTCATCACTTATGAAACCCAAACAGAGAGATCTAGAGCACAAACAATACA       AAGAGAACAGGAGCCTCAAAAGAAGAACAGGACTGACCCAAACATCTCTCCAGACCAGAGTTCTGGCT       TCAACTACACCCACTGCTATGACACCTCCTGTTCTAACCACAGCCGAAACTTCAGTCAGCCCAGTGTC       TCTGCATTCACTCATTCCCCACCAGAAACAACAACTGGGAATTTCAAGCACAATCAGTTTTCATTCAG       AACTCTTATCTGACAGATGTGATTGAAAGAAACTAGCCCAAGCAAGTACTCAGACTTTGAAGAGCACA       TTGCTTCTGAAACAACTTTGTCCAGCAATCACACCAGAGTACCACAACTAGGAAAGCAAATCATTAGA       CACTCAACCATACCACCATTCTTGAGCAGCAGTGCTACTCTAATGCCAGTTCCCATCTCCCCTCCCTT       TACTCAGAGAGCAGTTACTGACAACGTGGCGACTCCCATTTCCGGGCTTATGACAAATACAGTGGTCA       AGCTGCACGAATCCTCAAGGCACAATGCTACCAACAAGCAATTAGTAGCAGAGGTTGCAACATCCCCC       AAGGTTCACCCAAATGCCAAGTTCACAATTGGAACCACTCACTTCATCTACTCTAATCTGTTACATTC       TACTCCCATGCCAGCACTACAACAGTTAAATCAACAGAATTCTAAATTAACTCCATCTCCCTGGGCAG       AAAACCAATTTTGGCACAAACCATACTCAAGAAATTGCTGAAAAGGCAAAAAGCCAGAAGTAAGCATG       TTGGCTACTACAGGCCTGTCCGAGGCCACCACTCTTGTTTCAGATTGGGATGGACAGAAGAACACAAA       GAAGAGTGACTTTGATAAGAAACCAGTTCAAGAAGCAACAACTTCCAAACTCCTTCCCTTTGACTCTT       TGTCTAGGTATATATTTGAAGCCCAGGAAAATAGTTGGAAAAGAGCTGCAAGTTTTAACTATTCCAAT       AACTCAGATGCCTTTCTTCCCTGTGAAGCTGTTGGAAATCCCCTGCCCACCATTCATTGGACCAGAGT       CCCATCAGGTATGTCAGGACTTGATTTATCTAAGAGGAAACAGAATAGCAGGGTCCAGGTTCTCCCCA       ATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAAT       ACGTACCAAAGAGATCACAGTTCATTCCGGAAGCACTGTGGAACTGAAGTGCAGAGCAGAAGGTAGGC       CAAGCCCTACAGTTACCTGGATTCTTGCAAACCAAACAGTTGTCTCAGAATCATCCCAGGGAAGTAGG       AGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTAATGACCGTGGCTTTTA       CAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAATAACAAGTCATTGCAGCAC       CACCTGTTATTCTAGAGCAAGGAGGCAAGTCATTGTAAGGCAACTTGGGGTGAAAGTTTAAACTGCCC       TGTACTGCAAAAGGAACTCCTCAGCCCAGCGTTTACTGGGTCCTCTCTGATGGCACTGAAGTGAAACC       ATTACAGTTTACCAATTCCAAGTTGTTCTTATTTTCAAATGGGACTTTGTATATAAGAAACCTAGCCT       CTTCAGACAGGGGCACTTATGAATGCATTGCTACCAGTTCCACTGGTTCGGAGCGAAGAGTAGTAATG       CTTACAATGGAAGAGCGAGTGACCAGCCCCAGGATAGAAAGCTGCATCCCAGAAGGACTGAAAGTGAA       TTTTGGGGACATTACTACTGAACTGCTCAGCCACTGGGGAAGCCCAAAACCCCAAATAATGTGGAGGT       TACCATCCAAGGCTGTGGTCGACCAGCAGCATAGAGTGGGCAGCTGGATCCACGTCTACCCTAATGGA       TCCCTGTTTATTGGATCAGTAACAGAAGACAAGTGGTGTCTAACTTGTGTGTGGCAAAGAAACAAAAT       GGGGGATGATCTGATACTGATGCATGTTAGCCTAGAACTGAAACCTGCCAAAATTGACCACAAGCAGT       ATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTAGATTGCAAAGCTTCCGGCTCCCCAGTG       CCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAAATGCAGCCGATGACAGTGG       CCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTTTATACTTCAACAAAGTTGGGGTAGCGG       AGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGGAAAGATGAAATGAAGGTCCACTTAACA       GTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAACCMACAAGAGAAATCAAAGCTGGAGACAC       AGCTGTCCTTGACTGTGAGGTCATTCATGCCAAATGGGTCTTTGAACCATCAACAAGTGAACTGCTCG       ATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGAATGACACCAAATGTACAAACTGGAT       GTGGTCTCTAAACCTCCATTAATCAATGGTCTGTATACAAATAGAACTGTTATTAAAGCCACAGCTGT               GAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACACCATCTCCTGAAGTCATGTGGATCA       TGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAGAATCACAGTCCATAAAAATGGAACC       TTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTAATCTGTGTGGCCCGAAATGAGGTGG       AGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAAATGCTGAAGAAGACCGACATTTAGATCCAT       TTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATTGAATTGCTCTGTTGATGGTAACCCA       CCACCTGAAATAATCTGGATTTTACCAATGGCACACGATTTTCCAATGGACCACAAAAGTTATCAGTA       TCTGATAGCAAGCAATGGTTCTTTTATCATTTCTAACAACTCGGGAGGATGCAGGAAAAAATCATGCT       GTGCAGCTAGGAATAAAGTTGGCTATATTGAGAMATTAGTCATATTAGAAATTGGCCAGAAGCCAGTT       ATTCTTACCTATGCACCAGGGACAGTAAAGGCATCAGTGGAGAAACTCTAATCAACTAATTGTGTGTC       TGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGTGGTTATGTAGTAGACAGGCCTCAAA       TTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCATTAAAGAAGCAACAGCTTATGACAGA       GGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACACTGATTACTGTTCCAGTAATGATTGT       AGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATTGTCACCAGGACAGGGGCAGCCTTTC       AGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCACGTGGGAGATGCCTGACCACTCCCTT       CTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGCTTCACTTACAGGTACCCTAAGTCAT       TCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACAGCAAAGAACCCACTTGGTAGTGATT       ATGCAGCAACGTATATTCAAGTAATC TGA   CATGAAATAATAAAGTCAACAACATCTGGGCAGAATTTA         TTTTTTGGAAGAAGTTTAATCAAGGCAGCCATAGGCATGTAAATGATTTGAATAACAATTTACAGTAT       TAAATTTACAATGAACATGCAAAATAAAAGGACTTGTAAATAAATGCATTATGAACTGATGATACTGA       TTTATTTAATGGATCTCAAAACAAACTTTTAACTTAAGGCACTTTTATTTTGCCAACAAATAACAATA       AACAAACATTGAAACGGTTCACTATAAAATAACAAATGGCTAATGTACCTGAATTTTTCAGTAAAAAA       ATGAACTTCTAATACCAGTTGCCTAGTGTCCACCTCCTATCAATGTTACAAGCATGGCACTCAGAACA       GAGACAATGGAAAATATTAAATCTGCAATCTTTATGATGTAAATTTACCATCCTGATGTATAAATATT       TTGTGGTTTATAAATTTTTTTGCTAAAACCTACAGAAAAAAA                                         NOV29aa, CG55776-03   SEQ ID NO:718   2591 aa   MW at 287114.6 kD           Protein Sequence                     MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNTERINLGYNS           LVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVRLMVLKMSYNKVRKLQKDTFYGLRSLT       RLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSL       PQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPGIYIVLPDVIKCKKDRSPSSAQQCPLCDAP       ARTSKGKPLAMVSAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEAN       PQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEM       RPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKS       GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP       DASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRP       RENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEE       FMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKN       INPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTN       KLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPTPRNSTVNIPLFRR       FGRQRKIGGRGRIISPYRTPVLRRIRYSIFRSTTRGSSEKSTTAFSATKLNVTCLSCLPRERLTTATA       ALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTY       APTSIPMEKTHKNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPWQQNFVNNNH       NPKGRLRNQHKVSLQKSTAVMLPKTSPALPQRQSLPSHHTTTKTHNPGSLPTKKELPFPPLNPMLPSI       ISKDSSTKSISTQTAIPATTPTFPASVITYETQTERSIAAQTIQREQEPQKKNRTDPNISPDQSSGFT       TPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIA       SETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTNTVVKL       HESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAEN       QFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLS       RYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGMSGLDLSKRKQNSRVQVLPNG       TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILEPRTKEITVHSGSTVELKCRAEGRPS       PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP       VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIPNLASS       DRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLP       SKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLELKPAKIDHKQYF       RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE       GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVIHANGSLTINKVKLLDS       GEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMP       DNIFLTAPYYGSRITVHKNGTLIRNVRLSDSADFICVARNEGGESVLLVVQLEVLEMLRRPTFRNPFN       EKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCA       ARNKVGYIEKLVILEIGQKPVILTYAPGTKTKGISGESLSLHCVSDGPKPNTKWTMPSGYVVDRPQIN       GKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRRITNRPPRSIVTRTGAFQL       HCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYA       ATYIQVI                                     NOV29ab, CG55776-04   SEQ ID NO:719   771 bP           DNA Sequence   ORF Start: at 7   ORF Stop: at 766                       AAGCTT GCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCACATTTCGGTACCT           GACTTCCATCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGATACAACAAGCTTGGTTA       GATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCACAGCAATGGCATT       CACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTCTTAAAAATGAGCTATAACAA       AGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCTTGACACGATTGCACATGGACCACA       ACAATATTGAGTTTATAAACCCAGAGGTTTTTGATGGGCTCAACTTTCTCCGCCTGGTGCACTTGGAA       GGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTTGAGCTACCTCCAGATATTTAAAAT       CTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCTCCCTCCCTCAAGAGATGGTCTCCT       ATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGGACCTGTGATTGCCATTTAAAGTGG       TTGTCTGACTGGATACAGGAGAAGCCAGATGTAATAAAATGCAAAAAAAGATAGAGTCCCTCTAGTGC       TCAGCACTGTCCACTTTGCATGAACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTG       CAGCTTTCCAGTGTGCCCTC GAG                                           NOV29ab, CG55776-04   SEQ ID NO:720   253 aa   MW at 29129.5 kD           Protein Sequence                     ACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHT           IPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFDGLNFLRLVHLEGN       QLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLS       DWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAAFQCA                                     NOV29ac, CG55776-05   SEQ ID NO:721   2011 bP           DNA Sequence   ORF Start: at 32   ORF Stop: at 1988                       AGGCTCCGCGGCCGCCCCCTTCACCCTCGAG GGGGACAAATTACTACTGAACTGCTCAGCCACTGGGG           AGCCCAAACCCCAAATAATGTGGAGGTTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGAGTGGGC       AGCTGGATCCACGTCTACCCTAATGGATCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGT       CTACTTGTGTGTGGCAAGAAACAAAATGGGGGATGATCTGATACTGATGCATGTTAGCCTAAGACTGA       AACCTGCCAAATTGACCACAAGCAGTATTTTAGAPAAGCAAGTGCTCCATGGGAAGATTTCCAAAGTA       GATTGCAAGCTTCCGGCTCCCCAGTGCCAGAGATATCTTGGAAGTTTGCCTGAATGGACCATGAATCA       CATGCAAATGCAAGCCGATGACAGTGGCCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTT       TATACTTCAACAAAGTTGGGGTAAGCGGAAGGAAGGAGATTATACTTGCTATACCAGAACACCCTAAG       AAAGATGAAATGAAGGTCCACTTAACAGTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAAC       CAACAAGAGAATCAAAGCTGGAGACACAGCTGTCCTTGACTGTGAGGTCACTGGGGATCCCAAACCAA       AAATATTTTGGTTGCTGCCTTCCAATGACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCC       AATGGGTCTTTGACCATCAACAAAGTGAAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAA       TCCCAGTGGGGATGAACACCAAAATGTACAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTC       TGTATACAAACAGAAACTGTTATTAAAGCCACAGCTGTGAGACATTCCAAAAACACTTTGACTGCAGA       GCTGAAGGGACACCATCTCCTGAAGTCATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATA       CTATGGAAGCAGAATCACAGTCCATAAAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATT       CAGCCGACTTTATCTGTGTGGCCCGAAATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTA       CTGGAAATGCTGAGAAGACCGACATTTAGAATCCATTTAATGAAAAAAATAGTTGCCCAGCTGGGAAA       GTCCACAGCATTGAATTGCTCTGTTGATGGTAACCCACCACCTGAATAAATCTGGATTTTACCAAATG       GCACACGATTTTCCAATGGACCACAAAGTTATCAGTATCTGATAGCAGCAAATGGTTCTTTTATCATT       TCTAAAACAACTCGGGAGGATGCAGGAAAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGA       GAAATTAGTCATATTAGAAAATTGGCCAGAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAG       GCATCAGTGGAGAATCTCTATCACTGCATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGG       ACTATGCCAAGTGGTTATGTAGTAGACAGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGG       CACCTTAGTCATTAAAGAAGCAACAGCTTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTG       TTGGTCATACACTGATTACTGTTCCAGTAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCA       CCCAGGAGTATTGTCACCAGGACAGGGGCAGCCTTTCAGCTGGACTGTGTGGCCTTGGGAGTTCCCAA       GCCAGAAATCACAATGGGAGATGCCTGACCACTCCCTTCTCTCAACGGCAGTAAAGAGAGGACACATG       GAAGTGAGCAGCTTCACTTACAAGGTACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATA       TACAAATGCACAGCACTC GAGGGCAAGGGTGGGCGCGCC                                           NOV29aC, CG55776-05   SEQ ID NO:722   652 aa   MW at 72283.3 kD           Protein Sequence                     GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMG           DDLILMHVSLRLKPAKDHKQYFRKQKTLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGH       RTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMVHLTVITAAPRIRQSNKTNKRIKAGDTPA       VLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKAYK       LDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKN       GTLEIRNVRLSDSADFICVAPNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDG       NPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQK       PVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAY       DRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDH       SLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTA                                     NOV29ad, CG55776-06   SEQ ID NO:723   1975 bP           DNA Sequence   ORF Start: at 11   ORF Stop: at 1967                       CACCAGATCT GGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGT           GGAGGTTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGAGTGGGCAGCTGGATCCACGTCTACCCT       AATGGATCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGTCTACTTGTGTGTGGCAAGAAA       CAAAATGGGGGATGATCTGATACTGATGCATGTTAAAGCCTAAGACTGACCTGCCAAAATTGACCACA       AGCAGTATTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTAGAATTGCAAAGCTTCCGGCTCC       CCAGTGCCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAATGCAAGCCGATGA       CAGTGGCCACAGGACTAGGAGATATACCCTTTTCACATGGAACAATTTAATACTTCAACAAGTTGGGG       TAGCGGAGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGGAAAGATGAAATGAAGGTCCAC       TTAACAGTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAACCAACAAGAGAATCAAAGCTGG       AGACACAGCTGTCCTTGACTGTGAGGTCACTGGGGAATCCCAAACCAAAATATTTTGGTTGCTGCCTT       CCAATGACATGATTTCCTTCTCCATTGATAGGTACAACATTTCATGCCAATGGGTCTTTGACCATCAC       AAAGTGAAACTGCTCGATTCTGGAGAGTACGTAATGTGTAGCCCGATCCCAGTGGGGATGACACCAAA       AAATGTACAAACTGGATGTGGTCTCTAACCTCCAATTAATCAATGGTCTGTAATAACACAGACTGTTA       TTAAAGCCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACACCATCTCCT       CCATAAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTAATCTGTGTGG       CCCGAAATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTGAGAAGACCG       ACATTTAGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATTGAATTGCTC       TGTTGATGGTAACCCACCACCTGAUATAATCTGGATTTTACCAAATGGCACACGATTTTCCAATGGAC       CACAAAGTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATTTCTA1KAACACTCGGGAGGAT       GCAGGAAAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAAAGATTAGTCATATTAGAAAT       TGGCCAGAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAGAATCTCTAT       CACTGCATTGTGTGTCTGATGGAATCCCTAAGCCAATATCAAATGGACTATGCCAAAGTGGTTATGTA       GTAGACAGGCCTCAATTAATGGGAAATAAACATATTGCATGACATGGCACCTTAGTCATTAAAGAAGC       AACAGCTTATGACAGAGGAAACTATATCTGTAAGGCTCAAATAGTGTTGGTCATACAACTGATTACTG       TTCCAGTAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATTGTCACCAGG       ACAGGGGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCACATGGGAGAT       AAGGTACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACAGCAGAA TTC           GGC                                           NOV29ad, CG55776-06   SEQ ID NO:724   652 aa   MW at 72283.3 kD           Protein Sequence                     GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKAG           DDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGH       RTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTA       VLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYK       LDWSKPPLINGLYTNRTVIKATAVRHSKKIHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKN       GTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDG       NPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQK       PVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAY       DRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDH       SLLSTASKERTHGSEQLHLQGTLVTQNPQTSDSGIYKCTA                                     NOV29ae, CG55776-07   SEQ ID NO:725   2902 bP           DNA Sequence   ORF Start: at 11   ORF Stop: at 2894                       CACCCTCGAG AACTCAGATGCCTTTCTTCCCTGTGAAGCTGTTGGAAATCCCCTGCCCACCATTCATT           GGACCAGAGTCCCATCAGGACTTGATTTATCTAAGAGGAAACAGAATAGCAGGGTCCAGGTTCTCCCC       AATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAA       TCTGTTTGGCACAGACCACCTTCATGTCACCTTGTCTGTGGTTTCCTATCCTCCCAGGATCCTGGAGA       GACGTACCAAGAGATCACAGTTCATTCCGGAAGCACTGTGGACTGAAGTGCAGAGCAGAAAAGGTAGG       CCAAGCCCTACAGTTACCTGGATTCTTGCAAACCAAACAGTTGTCTCAGAATCATCCCAGGGAAGTAG       GCAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTATGACCGTGGCTTTT       ACAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAAATACAAGTCATTGCAGCA       CCACCTGTTATTCTAGAGCAAAGGAGGCAAGTCATTGTAGGCACTTGGGGTGAAAGTTTAAAACTGCC       CTGTACTGCAAAGGAACTCCTCAGCCCAGCGTTTACTGGGTCCTCTCTGATGGCACTGAAAGTGAAAC       CATTACAGTTTACCAATTCCAAGTTGTTCTTATTTTCAAATGGGACTTTGTATATAAGAAACCTAGCC       TCTTCAGACAGGGGCACTTATGAATGCATTGCTACCAGTTCCACTGGTTCGGAGCGAAGAGTAGTAAT       GCTTACAATGGAAGAGCGAGTGACCAGCCCCAGGATAGAAGCTGCATCCCAGAAAAGGACTGAAGTGA       ATTTTGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGTGGAGG       TTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGAGTGGGCAGCTGGATCCACGTCTACCCTAATGG       ATCCCTGTTTATTGGATCAGTAACAGAAGACAAAGTGGTGTCTAACTTGTGTGTGGCAAGAAACAAAA       TGGGGGATGATCTGATACTGATGCATGTTAGCCTAAGACTGAAACCTGCCAAAATTGACCACAAGCAG       TATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTAGATTGCAAAGCTTCCGGCTCCCCAGT       GCCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAATGCAAGCCGATGACAGTG       GCCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTTTATACTTCAACAAAGTTGGGGTAGCG       GAGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGGAAAGATGAAATGAAGGTCCACTTAAC       CAGCTGTCCTTGACTGTGAGGTCACTGGGGATCCCAAACCAAAAATATTTTGGTTGCTGCCTTCCAAT       GACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCCAATGGGTCTTTGACCATCAAACAAGT       GAAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGATGACACCAAAATGT       GCCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACACCATCTCCTGAAGT       CATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAGAATCACAGTCCATA       AAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTATCTGTGTGGCCCGA       AATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTGAGAAGACCGACATT       TAGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATTGAATTGCTCTGTTG       AGTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATTTCTAAAACAACTCGGGAGGATGCAGG       AAAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCATATTAGAAATTGGCC       AGAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAGAATCTCTATCACTG       CATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGTGGTTATGTAGTAGA       GTAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATTGTCACCAGGACAGG       GGCAAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAATCACGTGGGAGATGCCTG       ACCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGCTTCACTTAACAGGT       ACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACAGCAAAGAACCCACT       TGGTAGTGATTATGCAGCAACGTATATTCAAGTAATCCTC GAGGGC                                           NOV29ae, CG55776-07   SEQ ID NO:726   961 aa   MW at 106268.6 kD           Protein Sequence                     NSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFG           TDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVTSESSQGSRQAV       VTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTA       KGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTM       EERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLF       IGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEI       SWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVIT       AAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLL       DSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCREAGTPSPEVMWI       MPDNIFLTAPYYGSRITVHKINGTLEIRNVRLSDSADFICVARNEGGESVLVQLEVLEMLRRPTFRNP       FNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYR       CAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQ       INGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAF       QLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSD       YAATYIQVI                                     NOV29af, CG55776-08   SEQ ID NO:727   2902 bP           DNA Sequence   ORF Start: at 11   ORF Stop: at 2894                       CACCAGATCT AACTCAGATGCCTTTCTTCCCTGTGAAGCTGTTGGAAATCCCCTGCCCACCATTCATT           GGACCAGAGTCCCATCAGGACTTGATTTATCTAAGAGGAAACAGAATAGCAGGGTCCAGGTTCTCCCC       AATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAA       TCTGTTTGGCACAGACCACCTTCATGTCACCTTGTCTGTGGTTTCCTATCCTCCCAGGATCCTGGAGA       GACGTACCAAAGAGATCACAGTTCATTCCGGAAGCACTGTGGAACTGAAGTGCAGAGCAGAAGGTAGG       CCAAGCCCTACAGTTACCTGGATTCTTGCAAACCAAACAGTTGTCTCAGAATCATCCCAGGGAAGTAG       GCAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTATGACCGTGGCTTTT       ACAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTATAATACAAGTCATTGCAGCA       CCACCTGTTATTCTAGAGCAAAGGAGGCAAGTCATTGTAGGCACTTGGGGTGAAAGTTTAAAACTGCC       CTGTACTGCAAAAGGAACTCCTCAGCCCAGCGTTTACTGGGTCCTCTCTGATGGCACTGAAGTGAAAC       CATTACAGTTTACCAATTCCAAGTTGTTCTTATTTTCAAATGGGACTTTGTATATAAGAAACCTAGCC       TCTTCAGACAGGGGCACTTATGAATGCATTGCTACCAGTTCCACTGGTTCGGAGCGAAGAGTAGTAAT       GCTTACAATGGAAGAGCGAGTGACCAGCCCCAGGATAGAAGCTGCATCCCAGAAAAGGACTGAAGTGA       ATTTTGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGTGGAGG       TTACCATCCAAGGCTGTGGTCGACCAGCAGCATAGAGTGGGCAGCTGGATCCACGTCTACCCTAATGG       ATCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGTCTACTTGTGTGTGGCAAGAAACAAAA       TGGGGGATGATCTGATACTGATGCATGTTAGCCTAAGACTGAAACCTGCCAAAATTGACCACAAGCAG       TATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTAGATTGCAAAGCTTCCGGCTCCCCAGT       GCCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAATGCAAGCCGATGACAGTG       GCCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTTTATACTTCAACAAAGTTGGGGTAGCG       GAGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGGAAAGATGAAATGAAGGTCCACTTAAC       AGTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAACCAACAAGAGAATCAAAGCTGGAGACA       CAGCTGTCCTTGACTGTGAGGTCACTGGGGATCCCAAACCAAAAATATTTTGGTTGCTGCCTTCCAAT       GACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCCAATGGGTCTTTGACCATCAACAAAGT       GAAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGATGACACCAAAATGT       ACAAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTCTGTATACAAATAGAACTGTTATTAAA       CATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAGAATCACAGTCCATA       AAAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTATCTGTGTGGCCCGA       AATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTGAGAAGACCGACATT       TAGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATTGAATTGCTCTGTTG       ATGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATGGCACACGATTTTCCAATGGACCACAA       AAAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCATATTAGAAATTGGCC       AGAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAGAATCTCTATCACTG       CATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGTGGTTATGTAGTAGA       CAGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCATTAAAGAAGCAACAG       CTTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACACTGATTACTGTTCCA       GTAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATTGTCACCAGGACAGG       GGCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCACGTGGGAGATGCCTG       ACCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGCTTCACTTACAAGGT       ACCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACAGCAAAGAACCCACT       TGGTAGTGATTATGCAGCAACGTATATTCAAGTAATCCTC GAGGGC                                           NOV29af, CG55776-08   SEQ ID NO:728   961 aa   MW at 106268.6 kD           Protein Sequence                     NSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFG           TDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCEAEGRPSPTVTWILANQTVVSESSQGSRQAV       VTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTA       KGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIENLASSDRGTYECIATSSTGSERRVVMLTM       EERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLF       IGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKDHKQYFRKQKTLHGKDFQVDCKASGSPVPEI       SWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVIT       AAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLL       DSGEYVCVARAPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWI       MPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFANP       FNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYR       CAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQ       INGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAF       QLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSD       YAATYIQVI                                     NOV29ag, CG55776-09   SEQ ID NO:729   778 bP           DNA Sequence   ORF Start: at 11   ORF Stop: at 770                       CACCGGATCC GCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCACATTTCGGT           ACCTGACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGATACAACAGCTTG       GTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCACAGCAATGG       CATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTCTTAAAAATGAGCTATA       ACAAAGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCTTGACACGATTGCACATGGAC       CACAACAATATTGAGTTTATAAACCCAGAGGTTTTTGATGGGCTCAACTTTCTCCGCCTGGTGCACTT       GGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTTGAGCTACCTCCAGATATTTA       AAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCTCCCTCCCTCAAGAGATGGTC       TCCTATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGGACCTGTGATTGCCATTTAAA       GTGGTTGTCTGACTGGATACAGGAGAAGCCAGATGTAATAAAATGCAAAAAAGATAGAAGTCCCTCTA       GTGCTCAGCAGTGTCCACTTTGCATGAACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCA       GCTGCAGCTTTCCAGTGTGCCCTCGAGGGC                                         NOV29ag, CG55776-09   SEQ ID NO:730   253 aa   MW at 29129.5 kD                         ACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHT           IPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFDGLNFLRLVHLEGN       QLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLS       DWIQEKPDVIKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAAFQCA                                     NOV29ah, SNP13376522 of   SEQ ID NO:731   7876 bP           CG55776-01,   ORF Start: ATG at 6   ORF Stop: TGA at 7857       DNA Sequence   SNP Pos: 87   SNP Change: G to A                       TCAGG   ATG AAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCCTGGTC           GCCACCCCTGGGGGCAAG   A   CCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCAC       ATTTCGGTACCTGACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGGTACA       ACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCAC       AGCAATGGCATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTGAGACTGAT       GGTCTTAAAAATGAGCTATAATAAAGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCT       TGACACGATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAAC       TTTCTCCGCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTT       GAGCTACCTCCAGATATTTAAAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCT       CCCTCCCTCAAGAGATGGTCTCCTATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGG       ACCTGTGATTGCCATTTAAAGTGGTTGTCTGACTGGATACAGGAGAAGCCAGGTATCTATATTGTNTT       ACCAGATGTAATAAAATGCAAAAAAGATAGAAGTCCCTCTAGTGCTCAGCAGTGTCCACTTTGCATGA       ACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTGCAGCTTTCCAGTGTGCCAAGCCA       ACCATTGACTCATCCCTGAAATCAAAGAGCCTGACTATTCTGGAAGACAGTAGTTCTGCTTTCATCTC       TCCCCAAGGTTTCATGGCACCCTTTGGCTCCCTCACTTTGAATATGACAGATCAGTCTGGAAATGAAG       CTAACATGGTCTGCAGTATTCAAAAGCCCTCAAGGACATCACCCATTGCATTCACTGAAGAAAATGAC       TACATCGTGCTAAATACTTCATTTTCAACATTTTTGGTGTGCAACATAGATTACGGTCACATTCAGCC       AGTGTGGCAAATTTTGGCTTTGTACAGTGATTCTCCTCTGATACTAGAAAGGAGCCACTTGCTTAGTG       AAACACCGCAGCTCTATTACAAATATAAACAGGTGGCTCCTAAGCCTGAAGACATTTTTACCAACATA       GAGGCAGATCTCAGAGCAGATCCCTCTTGGTTAATGCAAGACCAAATTTCCTTGCAGCTGAACAGAAC       TGCCACCACATTCAGTACATTACAGATCCAGTACTCCAGTGATGCTCAAATCACTTTACCAAGAGCAG       AGATGAGGCCAGTGAAACACAAATGGACTATGATTTCAAGGGATAACAATACTAAGCTGGAACATACT       GTCTTGGTAGGTGGAACCGTTGGCCTGAACTGCCCAGGCCAAGGAGACCCCACCCCACACGTGGATTG       GCTTCTAGCTGATGGAAGTAAAGTGAGAGCCCCTTATGTCAGTGAGGATGGACGGATCCTAATAGACA       AAAGTGGAAAATTGGAACTCCAGATGGCTGATAGTTTTGACACAGGCGTATATCACTGTATAAGCAGC       AATTATGATGATGCAGATATTCTCACCTATAGGATAACTGTGGTAGAACCTTTGGTCGAAGCCTATCA       GGAAAATGGGATTCATCACACAGTTTTCATTGGTGAAACACTTGATCTTCCATGCCATTCTACTGGTA       TCCCAGATGCCTCTATTAGCTGGGTTATTCCAGGAAACAATGTGCTCTATCAGTCATCAAGAGACAAG       AAAGTTCTAAACAATGGCACATTAAGAATATTACAGGTCACCCCGAAAGACCAAGGTTATTATCGCTG       TGTGGCAGCCAACCCATCAGGGGTTGATTTTTTGATTTTCCAAGTTTCAGTCA7AGATGAAAGGACAA       GGCCCTTGGAGCATGATGGAGAAACAGAGGGATCTGGACTTGATGAGTCCAATCCTATTGCTCATCTT       AAGGAGCCACCAGGTGCACAACTCCGTACATCTGCTCTGATGGAGGCTGAGGTTGGAAAACACACCTC       AAGCACAAGTAAGAGGCACAACTATCGGGAATTAACACTCCAGCGACGTGGAGATTCAACACATCGAC       GTTTTAGGGAGAATAGGAGGCATTTCCCTCCCTCTGCTAGGAGAATTGACCCACAACATTGGGCGGCA       CTGTTGGAGAAAGCTAAAAAGAATGCTATGCCAGACAAGCGAGAAAATACCACAGTGAGCCCACCCCC       AGTGGTCACCCAACTCCCAAACATACCTGGTGAAGAAGACGATTCCTCAGGCATGCTCGCTCTACATG       AGGAATTTATGGTCCCGGCCACTAAAGCTTTGAACCTTCCAGCAAGGACAGTGACTGCTGACTCCAGA       ACAATATCTGATAGTCCTATGACAAACATAAATTATGGCACAGAATTCTCTCCTGTTGTGAATTCACA       AATACTACCACCTGAAGAACCCACAGATTTCAAACTGTCTACTGCTATTAAAACTACAGCCATGTCAA       AGAATATAAACCCAACCATGTCAAGCCAAATACAAGGCACAACCAATCAACATTCATCCACTGTCTTT       CCACTGCTACTTGGAGCAACTGAATTTCAGGACTCTGACCAGATGGGAAGAGGAAGAGAGCATTTCCA       AAGTAGACCCCCAATAACAGTAAGGACTATGATCAAAGATGTCAATGTCAAAATGCTTAGTAGCACCA       CCAACAAACTATTATTAGAGTCAGTAAATACCACAAATAGTCATCAGACATCTGTAAGAGAAGTGAGT       GAACCCAGGCACAATCACTTCTATTCTCACACTACTCAAATACTTAGCACCTCCACGTTCCCTTCAGA       TCCACACACAGCTGCTCATTCTCAGTTTCCGATCCCTAGAAATAGTACAGTTAACATCCCGCTGTTCA       GACGCTTTGGGAGGCAGAGGAAAATTGGCGGAAGGGGGCGGATTATCAGCCCATATAGAACTCCAGTT       CTGCGACGGCATAGATACAGCATTTTCAGGTCAACAACCAGAGGTTCTTCTGAAAAAAGCACTACTGC       ATTCTCAGCCACAGTGCTCAATGTGACATGTCTGTCCTGTCTTCCCAGGGAGAGGCTCACCACTGCCA       CAGCAGCATTGTCTTTTCCAAGTGCTGCTCCCATCACCTTCCCCAAAGCTGACATTGCTAGAGTCCCA               TCAGAAGAGTCTACAACTCTAGTCCAGAATCCACTATTACTACTTGAGAACAAACCCAGTGTAGAGAA       AACAACACCCACAATAAAATATTTCAGGACTGAAATTTCCCAAGTGACTCCAACTGGTGCAGTCATGA       CATATGCTCCAACATCCATACCCATGGAAAAAACTCACAAAGTAAACGCCAGTTACCCACGTGTGTCT       AGCACCAATGAAGCTAAAAGAGATTCAGTGATTACATCGTCACTTTCAGGTGCTATCACCAAGCCACC       AATGACTATTATAGCCATTACAAGGTTTTCAAAGAAGGAAATTCCCTGGCAACAGAACTTTGTAAATA       ACCATAACCCAAAGGCAGATTAAGGAATCAAACATAAAGTTAGTTTACAA3AAAGCACAGCTGTGATG       CTTCCTAAACATCTCCTGCTTTACCACAGAGAACAAAGTCTCCCCTCGCACCACACTACGACCAAAAC       ACACAATCCTGGAAGTCTTCCAACAAAGAAGGAGCTTCCCTTCCCACCCCTTAACCCTATGCTTCCTA       GTATTATAAGCAAAGACTCAAGTACAAIAAGCATCATATCAACGCAAACAGCAATACCAGCAACAACT       CCTACCTTCCCTGCATCTGTCATCACTTATGAAACCCAAACAGAGAGATCTAGAGCACAAACAATACA       AAGAGAACAGGAGCCTCAAGAAGAACAGGAACTGAACCCAAACATCTCTCCAGACCAGAGTTCTGGCT       TCACTACACCCACTGCTATGACACCTCCTGTTCTAACCACAGCCGAAACTTCAGTCAAGCCCAGTGTC       TCTGCATTCACTCATTCCCCACCAGAAAACACAACTGGGATTTCAAGCACAATCAGTTTTCATTCAAG       ACTCTTAATCTGACAGATGTGATTGAIAGAACTAGCCCAAGCAAGTACTCAGACTTTGAAGAGCACAA       TTGCTTCTGAACAACTTTGTCCAGCAAATCAACACCAGAGTACCACAACTAGGAAAGCAATCATTAGA       CACTCAACCATACCACCATTCTTGAGCAGCAGTGCTACTCTAATGCCAGTTCCCATCTCCCCTCCCTT       AAGGTTCACCCAAATGCCAAGTTCACAATTGGAACCACTCACTTCATCTACTCTAATCTGTTACATTC       TACTCCCATGCCAGCAACTAACAACAGTTAATCACAGAATTCTAAATTAACTCCATCTCCCTGGGCAG       AAAACCAATTTTGGCACAAACCATACTCAGAAATTGCTGAAAAAGGCAAAAAGCCAGAAGTAAGCATG       TTGGCTACTACAGGCCTGTCCGAGGCCACCACTCTTGTTTCAGATTGGGATGGACAGAAGAACACAAA       GAAGAGTGACTTTGATAAGAAACCAGTTCAAGAAGCAACAACTTCCAAACTCCTTCCCTTTGACTCTT       TGTCTAGGTATATATTTGAAAAGCCCAGGATAGTTGGAGGAAAAGCTGCAAGTTTTACTATTCCAGCT       CCCATCAGGTATGTCAGGACTTGATTTATCTAAGAGGAAACAGAATAGCAGGGTCCAGGTTCTCCCCA       ATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAAT       CTGTTTGGCACAGACCACCTTCATGTCACCTTGTCTGTGGTTTCCTATCCTCCCAGGATCCTGGAGAG       ACGTACCAAAGAGATCACAGTTCATTCCGGAAGCACTGTGGAACTGAAGTGCAGAGCAGAAGGTAGGC       CAAGCCCTACAGTTACCTGGATTCTTGCACCAAACAAAGTTGTCTCAGAATCATCCCAGGGAAGTAGG       CAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTATGACCGTGGCTTTTA       CAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAAATACAAGTCATTGCAGCAC       CACCTGTTATTCTAGAGCAAAGGAGGCAAGTCATTGTAGGCACTTGGGGTGAAAGTTTAAAACTGCCC       TGTACTGCAAAAGGAACTCCTCAGCCCAGCGTTTACTGGGTCCTCTCTGATGGCACTGAAGTGAAACC       ATTACAGTTTACCAATTCCAAGTTGTTCTTATTTTCAAATGGGACTTTGTATATAAGAAACCTAGCCT       CTTCAGACAGGGGCACTTATGAATGCATTGCTACCAGTTCCACTGGTTCGGAGCGAAGAGTAGTAATG       CTTACAATGGAAGAGCGAGTGACCAGCCCCAGGATAGAAGCTGCATCCCAGAAAAGGACTGAAGTGAA       TTTTGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGTGGAGGT       TACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGGTGGGCAGCTGGATCCACGTCTACCCTAATGGA       GGGGGATGATCTGATACTGATGCATGTTAGCCTAAGACTGAAACCTGCCAAAATTGACCACAAGCAGT       ATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTAGATTGCAAAGCTTCCGGCTCCCCAGTG       CCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAATGCAAGCCGATGACAGTGG       AGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGGAAAGATGAAATGAAGGTCCACTTAACA       GTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAACCAACAAGAGAATCAAAGCTGGAGACAC       AGCTGTCCTTGACTGTGAGGTCACTGGGGATCCCAAACCAAAAATATTTTGGTTGCTGCCTTCCAATG       ACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCCAATGGGTCTTTGACCATCAACAAAGTG       AAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGATGACACCAAAATGTA               CAAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTCTGTATACAAACAGAACTGTTATTAAAG       CCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACACCATCTCCTGAAGTC       ATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAGAATCACAGTCCATAA       AAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTATCTGTGTGGCCCGAA       ATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTGAGAAGACCGACATTT       AGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATTGAATTGCTCTGTTGA       TGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATGGCACACGATTTTCCAATGGACCACAAA       GTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATTTCTAAAACAACTCGGGAGGATGCAGGA       AAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCATATTAGAAATTGGCCA       GAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAGAATCTCTATCACTGC       ATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGTGGTTATGTAGTAGAC       AGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCATTAAAGAAGCAACAGC       TTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACACTGATTACTGTTCCAG       TAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATTGTCACCAGGACAGGG       GCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCACATGGGAGATGCCTGA       CCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGCTTCACTTACAAGGTA       CCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACAGCAAAGAACCCACTT       GGTAGTGATTATGCAGCAACGTATATTCAAGTAATC TGA   CATGAAATAATAAAGTC                                           NOV29ah, SNP13376522 of   SEQ ID NO:732   2617 aa   MW at 290230.2 kD           CG55776-01, Protein Sequence   SNP Pos: 28       SNP Change:                   Ala to Thr                     MKVKGRGITCLLVSFAVICLVATPGGKTCPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNS           LVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVRLMVLKNSYNKVRKLQKDTFYGLRSLT       RLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSL       PQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPGIYIVLPDVIKCKKDRSPSSAQQCPLCMNP       RTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEAN       MVCSIQKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSET       PQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEM       RPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVEAPYVSEDGRILIDKS       GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP       DASISWVIPGNAVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRP       LEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRF       RENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEE       FMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKN       INPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTN       KLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRR       FGRQRKIGGRGRIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATA       ALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTY       APTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPWQQNFVNNH       NPKGRLRNQHKVSLQKSTAVMLPKTSPALPQRQSLPSHHTTTKTHNPGSLPTKKELPFPPLNPMLPSI       ISKDSSTKSIISTQTAIPATTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFT       TPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIA       SETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTNTVVKL       HESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAEN       QFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLS       RYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGMSGLDLSKRKQNSRVQVLPNG       TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS       PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKTQVIAAPP       DRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLP       SKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF       RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE       GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDM       ISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKAT       AVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE       GGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSY       QYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHC       VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVM       IVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTL       VIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI                                     NOV29ai, SNP13377624   SEQ ID NO:733   7876 bP           of CG55776-01,   ORF Start: ATG at 6   ORF Stop: TGA at 7857       DNA Sequence   SNP Pos: 113   SNP Change: T to C                       TCAGG   ATG AAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCCTGGTC           GCCACCCCTGGGGGCAAGGCCTGTCCTCGCCGCTGTGCCTGTTA   C   ATGCCTACGGAGGTACACTGCAC       ATTTCGGTACCTGACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGGTACA       ACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCAC       AGCAATGGCATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTGAGACTGAT       GGTCTTAIAAATGAGCTATAATAAAGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCT       TGACACGATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAAC       TTTCTCCGCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTT       GAGCTACCTCCAGATATTTAAAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCT       CCCTCCCTCAAGAGATGGTCTCCTATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGG       ACCTGTGATTGCCATTTAAAGTGGTTGTCTGACTGGATACAGGAGAAGCCAGGTATCTATATTGTNTT       ACCAGATGTAATAAAATGCAAAAAAGATAGAAGTCCCTCTAGTGCTCAGCAGTGTCCACTTTGCATGA       ACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTGCAGCTTTCCAGTGTGCCAAGCCA       ACCATTGACTCATCCCTGAAATCAAAGAGCCTGACTATTCTGGAAGACAGTAGTTCTGCTTTCATCTC       TCCCCAAGGTTTCATGGCACCCTTTGGCTCCCTCACTTTGAATATGACAGATCAGTCTGGAAATGAAG       CTAACATGGTCTGCAGTATTCAAAAGCCCTCAAGGACATCACCCATTGCATTCACTGAAGAAAATGAC       TACATCGTGCTAAATACTTCATTTTCAACATTTTTGGTGTGCAACATAGATTACGGTCACATTCAGCC       AGTGTGGCAAATTTTGGCTTTGTACAGTGATTCTCCTCTGATACTAGAAAGGAGCCACTTGCTTAGTG       AAACACCGCAGCTCTATTACAAATATAAACAGGTGGCTCCTAAGCCTGAAGACATTTTTACCAACATA       GAGGCAGATCTCAGAGCAGATCCCTCTTGGTTAATGCAAGACCAAATTTCCTTGCAGCTGAACAGAAC       TGCCACCACATTCAGTACATTACAGATCCAGTACTCCAGTGATGCTCAAATCACTTTACCAAGAGCAG       AGATGAGGCCAGTGAAACACAAATGGACTATGATTTCAAGGGATAACAATACTAAGCTGGAACATACT       GTCTTGGTAGGTGGAACCGTTGGCCTGAACTGCCCAGGCCAAGGAGACCCCACCCCACACGTGGATTG       AAAGTGGAAAATTGGAACTCCAGATGGCTGATAGTTTTGACACAGGCGTATATCACTGTATAAGCAGC       AATTATGATGATGCAGATATTCTCACCTATAGGATAACTGTGGTAGAACCTTTGGTCGAAGCCTATCA       GGAAAATGGGATTCATCACACAGTTTTCATTGGTGAAACACTTGATCTTCCATGCCATTCTACTGGTA       TCCCAGATGCCTCTATTAGCTGGGTTATTCCAGGAAACAATGTGCTCTATCAGTCATCAAGAGACAAG       TGTGGCAGCCAACCCATCAGGGGTTGATTTTTTGATTTTCCAAGTTTCAGTCAAGATGAAAGGACAAA       GGCCCTTGGAGCATGATGGAGAAACAGAGGGATCTGGACTTGATGAGTCCAATCCTATTGCTCATCTT       AAGGAGCCACCAGGTGCACAACTCCGTACATCTGCTCTGATGGAGGCTGAGGTTGGAAAACACACCTC       GTTTTAGGGAGAATAGGAGGCATTTCCCTCCCTCTGCTAGGAGAATTGACCCACAACATTGGGCGGCA       CTGTTGGAGAAAGCTAAAAAGAATGCTATGCCAGACAAGCGAGAAAATACCACAGTGAGCCCACCCCC       AGTGGTCACCCAACTCCCAAACATACCTGGTGAAGAAGACGATTCCTCAGGCATGCTCGCTCTACATG       AGGAATTTATGGTCCCGGCCACTAAAGCTTTGAACCTTCCAGCAAGGACAGTGACTGCTGACTCCAGA       ACAATATCTGATAGTCCTATGACAAACATAAATTATGGCACAGAATTCTCTCCTGTTGTGAATTCACA       AATACTACCACCTGAAGAACCCACAGATTTCAAACTGTCTACTGCTATTAAAACTACAGCCATGTCAA       AGAATATAAACCCAACCATGTCAAGCCAAATACAAGGCACAACCAATCAACATTCATCCACTGTCTTT       CCACTGCTACTTGGAGCAACTGAATTTCAGGACTCTGACCAGATGGGAAGAGGAAGAGAGCATTTCCA       AAGTAGACCCCCAATAACAGTAAGGACTATGATCAAAGATGTCAATGTCAAAATGCTTAGTAGCACCA       GAACCCAGGCACAATCACTTCTATTCTCACACTACTCAAATACTTAGCACCTCCACGTTCCCTTCAGA       TCCACACACAGCTGCTCATTCTCAGTTTCCGATCCCTAGAAATAGTACAGTTAACATCCCGCTGTTCA       GACGCTTTGGGAGGCAGAGGAAAATTGGCGGAAGGGGGCGGATTATCAGCCCATATAGAACTCCAGTT       CTGCGACGGCATAGATACAGCATTTTCAGGTCAACAACCAGAGGTTCTTCTGAAAAAAGCACTACTGC       ATTCTCAGCCACAGTGCTCAATGTGACATGTCTGTCCTGTCTTCCCAGGGAGAGGCTCACCACTGCCA       CAGCAGCATTGTCTTTTCCAAGTGCTGCTCCCATCACCTTCCCCAAAGCTGACATTGCTAGAGTCCCA               TCAGAAGAGTCTACAACTCTAGTCCAGAATCCACTATTACTACTTGAGAACAAACCCAGTGTAGAGAA       AACAACACCCACAATAAAATATTTCAGGACTGAAATTTCCCAAGTGACTCCAACTGGTGCAGTCATGA       CATATGCTCCAACATCCATACCCATGGAIAAAACTCACAAAGTAAACGCCAGTTACCCACGTGTGTCT       AGCACCAATGAAGCTAAAAGAGATTCAGTGATTACATCGTCACTTTCAGGTGCTATCACCAAGCCACC       AATGACTATTATAGCCATTACAAGGTTTTCAAGAAGGAAAATTCCCTGGCAACAGAACTTTGTAAATA       ACCATAACCCAAAAGGCAGATTAAGGAATCAACATAAAGTTAGTTTACAAAAAAGCACAGCTGTGATG       CTTCCTAAAACATCTCCTGCTTTACCACAGAGACAAAGTCTCCCCTCGCACCACACTACGACCAAAAC       ACACAATCCTGGAAGTCTTCCAACAAAGAAGGAGCTTCCCTTCCCACCCCTTAACCCTATGCTTCCTA       GTATTATAAGCAAAGACTCAAGTACAAAAAGCATCATATCAACGCAAACAGCAATACCAGCAACAACT       CCTACCTTCCCTGCATCTGTCATCACTTATGAAACCCAAACAGAGAGATCTAGAGCACAAACAATACA       AAGAGAACAGGAGCCTCAAAAGAAGAACAGGACTGACCCAAACATCTCTCCAGACCAGAGTTCTGGCT       TCACTACACCCACTGCTATGACACCTCCTGTTCTAACCACAGCCGAAACTTCAGTCAAGCCCAGTGTC       TCTGCATTCACTCATTCCCCACCAGAAAACACAACTGGGATTTCAAGCACAATCAGTTTTCATTCAAG       AACTCTTAATCTGACAGATGTGATTGAAGAACTAGCCCAAGCAAGTACTCAGACTTTGAAGAGCACAA       TTGCTTCTGAAACAACTTTGTCCAGCAAATCACACCAGAGTACCACAACTAGGAAAGCAATCATTAGA       CACTCAACCATACCACCATTCTTGAGCAGCAGTGCTACTCTAATGCCAGTTCCCATCTCCCCTCCCTT       TACTCAGAGAGCAGTTACTGACAACGTGGCGACTCCCATTTCCGGGCTTATGACAAATACAGTGGTCA       AGCTGCACGAATCCTCAAGGCACAATGCTAAACCACAGCAATTAGTAGCAGAGGTTGCAACATCCCCC       AAGGTTCACCCAAATGCCAAGTTCACAATTGGAACCACTCACTTCATCTACTCTAATCTGTTACATTC       TACTCCCATGCCAGCACTAACAACAGTTAAATCACAGAATTCTAAATTAACTCCATCTCCCTGGGCAG       AAAACCAATTTTGGCACAAACCATACTCAGAAATTGCTGAAAAAGGCAAAAAGCCAGAAGTAAGCATG       TTGGCTACTACAGGCCTGTCCGAGGCCACCACTCTTGTTTCAGATTGGGATGGACAGAAGAACACAAA       GAAGAGTGACTTTGATAAGAAACCAGTTCAAGAAGCAACAACTTCCAAACTCCTTCCCTTTGACTCTT       TGTCTAGGTATATATTTGAAAAGCCCAGGATAGTTGGAGGAAAAGCTGCAAGTTTTACTATTCCAGCT       AACTCAGATGCCTTTCTTCCCTGTGAAGCTGTTGGAAATCCCCTGCCCACCATTCATTGGACCAGAGT       CCCATCAGGTATGTCAGGACTTGATTTATCTAAGAGGAAACAGAATAGCAGGGTCCAGGTTCTCCCCA       ATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAAT       CTGTTTGGCACAGACCACCTTCATGTCACCTTGTCTGTGGTTTCCTATCCTCCCAGGATCCTGGAGAG       ACGTACCAAAGAGATCACAGTTCATTCCGGAAGCACTGTGGAACTGAAGTGCAGAGCAGAAGGTAGGC       CAAGCCCTACAGTTACCTGGATTCTTGCAAACCAAACAGTTGTCTCAGAATCATCCCAGGGAAATAGG       CAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTATGACCGTGGCTTTTA       CAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAAATACAAGTCATTGCAGCAC       CACCTGTTATTCTAGAGCAAAGGAGGCAAGTCATTGTAGGCACTTGGGGTGAAAGTTTAAAACTGCCC       TGTACTGCAAAAGGAACTCCTCAGCCCAGCGTTTACTGGGTCCTCTCTGATGGCACTGAAGTGAAACC       ATTACAGTTTACCAATTCCAAGTTGTTCTTATTTTCAAATGGGACTTTGTATATAAGAAACCTAGCCT       CTTCAGACAGGGGCACTTATGAATGCATTGCTACCAGTTCCACTGGTTCGGAGCGAAGAGTAGTAATG       CTTACAATGGAAGAGCGAGTGACCAGCCCCAGGATAGAAGCTGCATCCCAGAAAAGGACTGAAGTGAA       TTTTGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGTGGAGGT       TACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGGTGGGCAGCTGGATCCACGTCTACCCTAATGGA       TCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGTCTACTTGTGTGTGGCAAGAAACAAAAT       GGGGGATGATCTGATACTGATGCATGTTAGCCTAAGACTGAAACCTGCCAAAATTGACCACAAGCAGT       ATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTAGATTGCAAAGCTTCCGGCTCCCCAGTG       CCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAATGCAAGCCGATGACAGTGG       CCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTTTATACTTCAACAAAGTTGGGGTAGCGG       AGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGGAAAGATGAAATGAAGGTCCACTTAACA       GTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAACCAACAAGAGAATCAAAGCTGGAGACAC       ACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCCAATGGGTCTTTGACCATCAACAAAGTG       AAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGATGACACCAAAATGTA               CAAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTCTGTATACAAACAGAACTGTTATTAAAG       CCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACACCATCTCCTGAAGTC       ATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAGAATCACAGTCCATAA       AAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTATCTGTGTGGCCCGAA       ATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTGAGAAGACCGACATTT       TGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATGGCACACGATTTTCCAATGGACCACAAA       GTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATTTCTAAAACAACTCGGGAGGATGCAGGA       AAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCATATTAGAAATTGGCCA       GAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAGAATCTCTATCACTGC       ATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGTGGTTATGTAGTAGAC       AGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCATTAAAGAAGCAACAGC       TTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACACTGATTACTGTTCCAG       TAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATTGTCACCAGGACAGGG       GCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCACATGGGAGATGCCTGA       CCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGCTTCACTTACAAGGTA       CCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACAGCAAAGAACCCACTT       GGTAGTGATTATGCAGCAACGTATATTCAAGTAATC TGA   CATGAAATAATAAAGTC                                           NOV29ai, SNP13377624 of   SEQ ID NO:734   2617 aa   MW at 2902002 kD           CG55776-01, Protein Sequence   SNP Pos:36       SNP Change: Tyr to Tyr                     MKVKGRGITCLLVSFAVICLVATPGGKACPRRCAC   Y   MPTEVHCTFRYLTSIPDSIPPNVERINLGYNS           LVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVRLMVLKMSYNKVRKLQKDTFYGLRSLT       RLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSL       PQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPGIYIVLPDVIKCKKDRSPSSAQQCPLCDAP       RTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEAN       MVCSIQKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSET       PQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEM       RPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKS       GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP       DASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRP       LEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRF       RENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEE       FMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKN       INPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTN       KLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRR       FGRQRKIGGRGRIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATA       ALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTY       APTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPWQQNFVNNH       NPKGRLPNQHKVSLQKSTAVMLPKTSPALPQRQSLPSHHTTTKTHNPGSLPTKKELPFPPLNPMLPSI       ISKDSSTKSIISTQTAIPATTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFT       TPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIA       SETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTNTVVKL       HESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAEN       QFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLS       RYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGMSGLDLSKRKQNSRVQVLPNG       TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS       PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP       VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIPNLASS       DRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLP       SKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF       RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE       GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDM       ISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYThRTVIKAT       AVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE       GGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSY       QYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHC       VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVM       IVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTL       VIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI                                     NOV29a, SNP13377625   SEQ ID NO:735   7876 bP           of CG55776-01,   ORF Start: ATG at 6   ORF Stop: TGA at 7857       DNA Sequence   SNP PoS: 161   SNP Change: A to G                       TCAGG   ATG AAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCCTGGTC           GCCACCCCTGGGGGCAAGGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCAC       ATTTCGGTACCTGACTTCCATCCCGGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGGTACA       ACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCAC       TGACACGATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAAC       TTTCTCCGCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTT       GAGCTACCTCCAGATATTTAAAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCT       ACCTGTGATTGCCATTTAAAGTGGTTGTCTGACTGGATACAGGAGAAGCCAGGTATCTATATTGTNTT       ACCAGATGTAATAAAATGCAAAAAAGATAGAAGTCCCTCTAGTGCTCAGCAGTGTCCACTTTGCATGA       ACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTGCAGCTTTCCAGTGTGCCAAGCCA       ACCATTGACTCATCCCTGAAATCAAAGAGCCTGACTATTCTGGAAGACAGTAGTTCTGCTTTCATCTC       TCCCCAAGGTTTCATGGCACCCTTTGGCTCCCTCACTTTGAATATGACAGATCAGTCTGGAAATGAAG       CTAACATGGTCTGCAGTATTCAAAAGCCCTCAAGGACATCACCCATTGCATTCACTGAAGAAAATGAC       TACATCGTGCTAAATACTTCATTTTCACAATTTTTGGTGTGCAACATAGATTACGGTCACATTCAGCC       AGTGTGGCAAATTTTGGCTTTGTACAGTGATTCTCCTCTGATACTAGAAAGGAGCCACTTGCTTAGTG       AAACACCGCAGCTCTATTACAAATATAAACAGGTGGCTCCTAAGCCTGAAGACATTTTTACCAACATA       GAGGCAGATCTCAGAGCAGATCCCTCTTGGTTAATGCAAGACCAAATTTCCTTGCAGCTGAACAGAAC       TGCCACCACATTCAGTACATTACAGATCCAGTACTCCAGTGATGCTCAAATCACTTTACCAAGAGCAG       AGATGAGGCCAGTGAAACACAAATGGACTATGATTTCAAGGGATAACAATACTAAGCTGGAACATACT       GTCTTGGTAGGTGGAACCGTTGGCCTGAACTGCCCAGGCCAAGGAGACCCCACCCCACACGTGGATTG       GCTTCTAGCTGATGGAAGTAAAGTGAGAGCCCCTTATGTCAGTGAGGATGGACGGATCCTAATAGACA       AAAGTGGAAAATTGGAACTCCAGATGGCTGATAGTTTTGACACAGGCGTATATCACTGTATAAGCAGC       GGAAAATGGGATTCATCACACAGTTTTCATTGGTGAAACACTTGATCTTCCATGCCATTCTACTGGTA       TCCCAGATGCCTCTATTAGCTGGGTTATTCCAGGAAACAATGTGCTCTATCAGTCATCAAGAGACAAG       AAAGTTCTAAACAATGGCACATTAAGAATATTACAGGTCACCCCGAAAGACCAAGGTTATTATCGCTG       TGTGGCAGCCAACCCATCAGGGGTTGATTTTTTGATTTTCCAAGTTTCAGTCAAGATGAAAGGACAAA       GGCCCTTGGAGCATGATGGAGAAACAGAGGGATCTGGACTTGATGAGTCCAATCCTATTGCTCATCTT       AAGGAGCCACCAGGTGCACAACTCCGTACATCTGCTCTGATGGAGGCTGAGGTTGGAAAACACACCTC       AAGCACAAGTAAGAGGCACAACTATCGGGAATTAACACTCCAGCGACGTGGAGATTCAACACATCGAC       GTTTTAGGGAGAATAGGAGGCATTTCCCTCCCTCTGCTAGGAGAATTGACCCACAACATTGGGCGGCA       CTGTTGGAGAAAGCTAAAAAGAATGCTATGCCAGACAAGCGAGAAAATACCACAGTGAGCCCACCCCC       AGTGGTCACCCAACTCCCAAACATACCTGGTGAAGAAGACGATTCCTCAGGCATGCTCGCTCTACATG       AGGAATTTATGGTCCCGGCCACTAAAGCTTTGAACCTTCCAGCAAGGACAGTGACTGCTGACTCCAGA       ACAATATCTGATAGTCCTATGACAAACATAAATTATGGCACAGAATTCTCTCCTGTTGTGAATTCACA       AATACTACCACCTGAAGAACCCACAGATTTCAAACTGTCTACTGCTATTAAAACTACAGCCATGTCAA       AGAATATAAACCCAACCATGTCAAGCCAMATACAAGGCACAACCAATCAACATTCATCCACTGTCTTT       CCACTGCTACTTGGAGCAACTGAATTTCAGGACTCTGACCAGATGGGAAGAGGAAGAGAGCATTTCCA       AAGTAGACCCCCAATAACAGTAAGGACTATGATCAAAGATGTCAATGTCAAAATGCTTAGTAGCACCA       CCAACAAACTATTATTAGAGTCAGTAAATACCACAAATAGTCATCAGACATCTGTAAGAGAAGTGAGT       GAACCCAGGCACAATCACTTCTATTCTCACACTACTCAAATACTTAGCACCTCCACGTTCCCTTCAGA       TCCACACACAGCTGCTCATTCTCAGTTTCCGATCCCTAGAAATAGTACAGTTAACATCCCGCTGTTCA       GACGCTTTGGGAGGCAGAGGAAAATTGGCGGAAGGGGGCGGATTATCAGCCCATATAGAACTCCAGTT       CTGCGACGGCATAGATACAGCATTTTCAGGTCAACAACCAGAGGTTCTTCTGAAAAAAGCACTACTGC       ATTCTCAGCCACAGTGCTCAATGTGACATGTCTGTCCTGTCTTCCCAGGGAGAGGCTCACCACTGCCA       CAGCAGCATTGTCTTTTCCAAGTGCTGCTCCCATCACCTTCCCCAAAGCTGACATTGCTAGAGTCCCA               TCAGAAGAGTCTACAACTCTAGTCCAGAATCCACTATTACTACTTGAGAACAAACCCAGTGTAGAGAA       AACAACACCCACAATAAAATATTTCAGGACTGAAATTTCCCAAGTGACTCCAACTGGTGCAGTCATGA       CATATGCTCCAACATCCATACCCATGGAAAAAACTCACAAAGTAAACGCCAGTTACCCACGTGTGTCT       AGCACCAATGAAGCTAAAAGAGATTCAGTGATTACATCGTCACTTTCAGGTGCTATCACCAAGCCACC       AATGACTATTATAGCCATTACAAGGTTTTCAAGAAGGAAAATTCCCTGGCAACAGAACTTTGTAAATA       ACCATAACCCAAAAGGCAGATTAAGGAATCAACATAAAGTTAGTTTACAAAAAAGCACAGCTGTGATG       CTTCCTAAAACATCTCCTGCTTTACCACAGAGACAAAGTCTCCCCTCGCACCACACTACGACCAAAAC       ACACAATCCTGGAAGTCTTCCAACAAAGAAGGAGCTTCCCTTCCCACCCCTTAACCCTATGCTTCCTA       GTATTATAAGCAAAGACTCAAGTACAAAAAGCATCATATCAACGCAAACAGCAATACCAGCAACAACT       AAGAGAACAGGAGCCTCAAAAGAAGAACAGGACTGACCCAAACATCTCTCCAGACCAGAGTTCTGGCT       TCACTACACCCACTGCTATGACACCTCCTGTTCTAACCACAGCCGAAACTTCAGTCAAGCCCAGTGTC       AACTCTTAATCTGACAGATGTGATTGAAGAACTAGCCCAAGCAAGTACTCAGACTTTGAAGAGCACAA       TTGCTTCTGAAACAACTTTGTCCAGCAAATCACACCAGAGTACCACAACTAGGAAAGCAATCATTAGA       TACTCAGAGAGCAGTTACTGACAACGTGGCGACTCCCATTTCCGGGCTTATGACAAATACAGTGGTCA       AGCTGCACGAATCCTCAAGGCACAATGCTAAACCACAGCAATTAGTAGCAGAGGTTGCAACATCCCCC       AAGGTTCACCCAAATGCCAAGTTCACAATTGGAACCACTCACTTCATCTACTCTAATCTGTTACATTC       TACTCCCATGCCAGCACTAACAACAGTTAAATCACAGAATTCTAAATTAACTCCATCTCCCTGGGCAG       AAAACCAATTTTGGCACAAACCATACTCAGAAATTGCTGAAAAAGGCAAAAAGCCAGAAGTAAGCATG       TTGGCTACTACAGGCCTGTCCGAGGCCACCACTCTTGTTTCAGATTGGGATGGACAGAAGAACACAAA       GAAGAGTGACTTTGATAAGAAACCAGTTCAAGAAGCAACAACTTCCAAACTCCTTCCCTTTGACTCTT       TGTCTAGGTATATATTTGAAAAGCCCAGGATAGTTGGAGGAAAAGCTGCAAGTTTTACTATTCCAGCT       CCCATCAGGTATGTCAGGACTTGATTTATCTAAGAGGAAACAGAATAGCAGGGTCCAGGTTCTCCCCA       ATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAAT       CTGTTTGGCACAGACCACCTTCATGTCACCTTGTCTGTGGTTTCCTATCCTCCCAGGATCCTGGAGAG       ACGTACCAAAGAGATCACAGTTCATTCCGGAAGCACTGTGGAACTGAAGTGCAGAGCAGAAGGTAGGC       CAAGCCCTACAGTTACCTGGATTCTTGCAAACCAAACAGTTGTCTCAGAATCATCCCAGGGAAGTAGG       CAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTATGACCGTGGCTTTTA       CAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAAATACAAGTCATTGCAGCAC       CACCTGTTATTCTAGAGCAAAGGAGGCAAGTCATTGTAGGCACTTGGGGTGAAAGTTTAAAACTGCCC       TGTACTGCAAAAGGAACTCCTCAGCCCAGCGTTTACTGGGTCCTCTCTGATGGCACTGAAGTGAAACC       ATTACAGTTTACCAATTCCAAGTTGTTCTTATTTTCAAATGGGACTTTGTATATAAGAAACCTAGCCT       CTTCAGACAGGGGCACTTATGAATGCATTGCTACCAGTTCCACTGGTTCGGAGCGAAGAGTAGTAATG       CTTACAATGGAAGAGCGAGTGACCAGCCCCAGGATAGAAGCTGCATCCCAGAkAAGGACTGAAGTGAA       TTTTGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGTGGAGGT       TACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGGTGGGCAGCTGGATCCACGTCTACCCTAATGGA       TCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGTCTACTTGTGTGTGGCAAGAAACAAAAT       GGGGGATGATCTGATACTGATGCATGTTAGCCTAAGACTGAAACCTGCCAAAATTGACCACAAGCAGT       ATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTAGATTGCAAAGCTTCCGGCTCCCCAGTG       CCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAATGCAAGCCGATGACAGTGG       CCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTTTATACTTCAACAAAGTTGGGGTAGCGG       AGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGGAAAGATGAAATGAAGGTCCACTTAACA       GTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAACCAACAAGAGAATCAAAGCTGGAGACAC       AGCTGTCCTTGACTGTGAGGTCACTGGGGATCCCAAACCAALAATATTTTGGTTGCTGCCTTCCAATG       ACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCCAATGGGTCTTTGACCATCAACAAAGTG       AAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGATGACACCAAAATGTA               CAAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTCTGTATACAAACAGAACTGTTATTAAAG       CCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACACCATCTCCTGAAGTC       ATGTGGAATCATGCCAGACATATTTTCCTCACAGCCCCATACTATGGAAAGCAGATCACAGTCCATAA       AAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTATCTGTGTGGCCCGAA       ATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTGAGAAGACCGACATTT       AGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATTGAATTGCTCTGTTGA       TGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATGGCACACGATTTTCCAATGGACCACAAA       GTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATTTCTAAAACAACTCGGGAGGATGCAGGA       AAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCATATTAGAAATTGGCCA       GAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAGAATCTCTATCACTGC       ATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGTGGTTATGTAGTAGAC       AGGCCTCATTAIATGGGAAATACATATTGCATGACAATGGCACCTTAGTCATTAAAGAAAGCAACAGC       TTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACACTGATTACTGTTCCAG       TAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATTGTCACCAGGACAGGG       GCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCACATGGGAGATGCCTGA       CCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGCTTCACTTACAAGGTA       CCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACAGCAAAGAACCCACTT       GGTAGTGATTATGCAGCAACGTATATTCAGTAATC TGA   CATGAATAATAGTC                                           NOV29a, SNP13377625 of   SEQ ID NO:736   2617 aa   MW at 290200.2 kD           CG55776-01, Protein Sequence   ASNP PoS: 52       SNP Change:                   Pro to Pro                     MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSI   P   DSIPPNVERINLGYNS           LVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVRLMVLKMSYNKVRKLQKDTFYGLRSLT       RLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSL       PQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPGIYIVLPDVIKCKKDRSPSSAQQCPLCMNP       RTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEAN       MVCSIQKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSET       PQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEM       RPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKS       GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP       DASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRP       LEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRF       RENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVVSPPPWTQLPNIPGEEDDSSGMLALHEE       FMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKN       INPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTN       KLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRR       FGRQRKIGGRGRIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATA       ALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTY       APTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPWQQNFVNNH       NPKGRLRNQHKVSLQKSTAVMLPKTSPALPQRQSLPSHHTTTKTHNPGSLPTKKELPFPPLNPMLPSI       ISKDSSTKSIISTQTAIPATTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFT       TPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIA       SETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTNTVVKL       HESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAEN       QFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLS       RYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGMSGLDLSKRKQNSRVQVLPNG       TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS       PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP       VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASS       DRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLP       SKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF       RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE       GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDM       ISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKAT       AVRHSKKHFDCPAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE       GGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSY       QYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHC       VSDGIPKPNTKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVM       IVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTL       VIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI                                     NOV29ak, SNP13376523 of   SEQ ID NO:737   7876 bP           CG55776-01,   ORF Start: ATG at 6   ORF Stop: TGA at 7857       DNA Sequence   SNP Pos: 187   SNP Change: G to A                       TCAGG   ATG AAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCCTGGTC           GCCACCCCTGGGGGCAAGGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCAC       ATTTCGGTACCTGACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAAC   A   CATCAATTTAGGGTACA       ACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCAC       AGCAATGGCATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTGAGACTGAT       GGTCTTAAAAATGAGCTATAATAAAGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCT       TGACACGATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAAC       TTTCTCCGCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTT       GAGCTACCTCCAGATATTTAAAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCT       CCCTCCCTCAAGAGATGGTCTCCTATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGG       ACCTGTGATTGCCATTTAAAGTGGTTGTCTGACTGGATACAGGAGAAGCCAGGTATCTATATTGTNTT       ACCAGATGTAATAAAATGCAAAAAAGATAGAAGTCCCTCTAGTGCTCAGCAGTGTCCACTTTGCATGA       ACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTGCAGCTTTCCAGTGTGCCAAGCCA       ACCATTGACTCATCCCTGAAATCAAAGAGCCTGACTATTCTGGAAGACAGTAGTTCTGCTTTCATCTC       TCCCCAAGGTTTCATGGCACCCTTTGGCTCCCTCACTTTGAATATGACAGATCAGTCTGGAAATGAAG       CTAACATGGTCTGCAGTATTCAAAAGCCCTCAAGGACATCACCCATTGCATTCACTGAAGAAAATGAC       TACATCGTGCTAAATACTTCATTTTCAACATTTTTGGTGTGCAACATAGATTACGGTCACATTCAGCC       AGTGTGGCAAATTTTGGCTTTGTACAGTGATTCTCCTCTGATACTAGAAAGGAGCCACTTGCTTAGTG       AAACACCGCAGCTCTATTACAAATATAAACAGGTGGCTCCTAAGCCTGAAGACATTTTTACCAACATA       TGCCACCACATTCAGTACATTACAGATCCAGTACTCCAGTGATGCTCAAATCACTTTACCAAGAGCAG       AGATGAGGCCAGTGAAACACAAATGGACTATGATTTCAAGGGATAACAATACTAAGCTGGAACATACT       GTCTTGGTAGGTGGAACCGTTGGCCTGAACTGCCCAGGCCAAGGAGACCCCACCCCACACGTGGATTG       GCTTCTAGCTGATGGAAGTAAAGTGAGAGCCCCTTATGTCAGTGAGGATGGACGGATCCTAATAGACA       AAAGTGGAAAATTGGAACTCCAGATGGCTGATAGTTTTGACACAGGCGTATATCACTGTATAAGCAGC       AATTATGATGATGCAGATATTCTCACCTATAGGATAACTGTGGTAGAACCTTTGGTCGAAGCCTATCA       TCCCAGATGCCTCTATTAGCTGGGTTATTCCAGGAAACAATGTGCTCTATCAGTCATCAAGAGACAAG       AAAGTTCTAAACAATGGCACATTAAGAATATTACAGGTCACCCCGAAAGACCAAGGTTATTATCGCTG       TGTGGCAGCCAACCCATCAGGGGTTGATTTTTTGATTTTCCAAGTTTCAGTCAAGATGAAAGGACAAA       GGCCCTTGGAGCATGATGGAGAAACAGAGGGATCTGGACTTGATGAGTCCAATCCTATTGCTCATCTT       AAGGAGCCACCAGGTGCACAACTCCGTACATCTGCTCTGATGGAGGCTGAGGTTGGAAAACACACCTC       AAGCACAAGTAAGAGGCACAACTATCGGGAATTAACACTCCAGCGACGTGGAGATTCAACACATCGAC       GTTTTAGGGAGAATAGGAGGCATTTCCCTCCCTCTGCTAGGAGAATTGACCCACAACATTGGGCGGCA       CTGTTGGAGAAAGCTAAAAAGAATGCTATGCCAGACAAGCGAGAAAATACCACAGTGAGCCCACCCCC       AGTGGTCACCCAACTCCCAAACATACCTGGTGAAGAAGACGATTCCTCAGGCATGCTCGCTCTACATG       AGGAATTTATGGTCCCGGCCACTAAAGCTTTGAACCTTCCAGCAAGGACAGTGACTGCTGACTCCAGA       ACAATATCTGATAGTCCTATGACAAACATAAATTATGGCACAGAATTCTCTCCTGTTGTGAATTCACA       AGAATATAAACCCAACCATGTCAAGCCAAATACAAGGCACAACCAATCAACATTCATCCACTGTCTTT       CCACTGCTACTTGGAGCAACTGAATTTCAGGACTCTGACCAGATGGGAAGAGGAAGAGAGCATTTCCA       AAGTAGACCCCCAATAACAGTAAGGACTATGATCAAAGATGTCAATGTCAAAATGCTTAGTAGCACCA       CCAACAAACTATTATTAGAGTCAGTAAATACCACAAATAGTCATCAGACATCTGTAAGAGAAGTGAGT       GAACCCAGGCACAATCACTTCTATTCTCACACTACTCAAATACTTAGCACCTCCACGTTCCCTTCAGA       TCCACACACAGCTGCTCATTCTCAGTTTCCGATCCCTAGAAATAGTACAGTTAACATCCCGCTGTTCA       GACGCTTTGGGAGGCAGAGGAAAATTGGCGGAAGGGGGCGGATTATCAGCCCATATAGAACTCCAGTT       CTGCGACGGCATAGATACAGCATTTTCAGGTCAACAACCAGAGGTTCTTCTGAAAAAAGCACTACTGC       ATTCTCAGCCACAGTGCTCAATGTGACATGTCTGTCCTGTCTTCCCAGGGAGAGGCTCACCACTGCCA       CAGCAGCATTGTCTTTTCCAAGTGCTGCTCCCATCACCTTCCCCAAAGCTGACATTGCTAGAGTCCCA               TCAGAAGAGTCTACAACTCTAGTCCAGAATCCACTATTACTACTTGAGAACAAACCCAGTGTAGAGAA       AACAACACCCACAATAAAATATTTCAGGACTGAAATTTCCCAAGTGACTCCAACTGGTGCAGTCATGA       CATATGCTCCAACATCCATACCCATGGAAAAAACTCACAAAGTAAACGCCAGTTACCCACGTGTGTCT       AGCACCAATGAAGCTAAAAGAGATTCAGTGATTACATCGTCACTTTCAGGTGCTATCACCAAGCCACC       AATGACTATTATAGCCATTACAAGGTTTTCAAGAAGGAAAATTCCCTGGCAACAGAACTTTGTAAATA       ACCATAACCCAAAAGGCAGATTAAGGAATCAACATAAAGTTAGTTTACAAAAAAGCACAGCTGTGATG       CTTCCTAAAACATCTCCTGCTTTACCACAGAGACAAAGTCTCCCCTCGCACCACACTACGACCAAAAC       ACACAATCCTGGAAGTCTTCCAACAAAGAAGGAGCTTCCCTTCCCACCCCTTAACCCTATGCTTCCTA       GTATTATAAGCAAAGACTCAAGTACAAAAAGCATCATATCAACGCAAACAGCAATACCAGCAACAACT       CCTACCTTCCCTGCATCTGTCATCACTTATGAAACCCAAACAGAGAGATCTAGAGCACAAACAATACA       AAGAGAACAGGAGCCTCAAAAGAAGAACAGGACTGACCCAAACATCTCTCCAGACCAGAGTTCTGGCT       TCACTACACCCACTGCTATGACACCTCCTGTTCTAACCACAGCCGAAACTTCAGTCAAGCCCAGTGTC       TCTGCATTCACTCATTCCCCACCAGAAAACACAACTGGGATTTCAAGCACAATCAGTTTTCATTCAAG       AACTCTTAATCTGACAGATGTGATTGAAGAACTAGCCCAAGCAAGTACTCAGACTTTGAAGAGCACAA       TTGCTTCTGAAACAACTTTGTCCAGCAAATCACACCAGAGTACCACAACTAGGAAAGCAATCATTAGA       CACTCAACCATACCACCATTCTTGAGCAGCAGTGCTACTCTAATGCCAGTTCCCATCTCCCCTCCCTT       TACTCAGAGAGCAGTTACTGACAACGTGGCGACTCCCATTTCCGGGCTTATGACAAATACAGTGGTCA       AGCTGCACGAATCCTCAAGGCACAATGCTAAACCACAGCAATTAGTAGCAGAGGTTGCAACATCCCCC       AAGGTTCACCCAAATGCCAAGTTCACAATTGGAACCACTCACTTCATCTACTCTAATCTGTTACATTC       TACTCCCATGCCAGCACTAACAACAGTTAAATCACAGAATTCTAAATTAACTCCATCTCCCTGGGCAG       AAAACCAATTTTGGCACAAACCATACTCAGAAATTGCTGAAAAAGGCAAAAAGCCAGAAGTAAGCATG       TTGGCTACTACAGGCCTGTCCGAGGCCACCACTCTTGTTTCAGATTGGGATGGACAGAAGAACACAAA       GAAGAGTGACTTTGATAAGAAACCAGTTCAAGAAGCAACAACTTCCAAACTCCTTCCCTTTGACTCTT       TGTCTAGGTATATATTTGAAAAGCCCAGGATAGTTGGAGGAAAAGCTGCAAGTTTTACTATTCCAGCT       AACTCAGATGCCTTTCTTCCCTGTGAAGCTGTTGGAAATCCCCTGCCCACCATTCATTGGACCAGAGT       CCCATCAGGTATGTCAGGACTTGATTTATCTAAGAGGAAACAGAATAGCAGGGTCCAGGTTCTCCCCA       ATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAAT       CTGTTTGGCACAGACCACCTTCATGTCACCTTGTCTGTGGTTTCCTATCCTCCCAGGATCCTGGAGAG       ACGTACCAAAGAGATCACAGTTCATTCCGGAAGCACTGTGGAACTGAAGTGCAGAGCAGAAGGTAGGC       CAAGCCCTACAGTTACCTGGATTCTTGCAAACCAAACAGTTGTCTCAGAATCATCCCAGGGAACTAGG       CAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTATGACCGTGGCTTTTA       CAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAAATACAAGTCATTGCAGCAC       CACCTGTTATTCTAGAGCAAAGGAGGCAAGTCATTGTAGGCACTTGGGGTGAAAGTTTAAAACTGCCC       ATTACAGTTTACCAATTCCAAGTTGTTCTTATTTTCAAATGGGACTTTGTATATAAGAAACCTAGCCT       CTTCAGACAGGGGCACTTATGAATGCATTGCTACCAGTTCCACTGGTTCGGAGCGAAGAGTAGTAATG       CTTACAATGGAAGAGCGAGTGACCAGCCCCAGGATAGAAGCTGCATCCCAGAAAAGGACTGAAGTGAA       TTTTGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGTGGAGGT       TACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGGTGGGCAGCTGGATCCACGTCTACCCTAATGGA       TCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGTCTACTTGTGTGTGGCAAGAAACAAAAT       ATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTAGATTGCAMAGCTTCCGGCTCCCCAGTG       CCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAATGCAAGCCGATGACAGTGG       CCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTTTATACTTCAACAAAGTTGGGGTAGCGG       AGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGGAAAGATGAAATGAAGGTCCACTTAACA       GTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAACCAACAAGAGAATCAAAGCTGGAGACAC       AGCTGTCCTTGACTGTGAGGTCACTGGGGATCCCAAACCAAAAATATTTTGGTTGCTGCCTTCCAATG       ACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCCAATGGGTCTTTGACCATCAACAAAGTG       AAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGATGACACCAAAATGTA               CAAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTCTGTATACAAACAGAACTGTTATTAAAG       CCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACACCATCTCCTGAAGTC       ATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAGAATCACAGTCCATAA       AAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTATCTGTGTGGCCCGAA       ATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTGAGAAGACCGACATTT       AGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATTGAATTGCTCTGTTGA       TGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATGGCACACGATTTTCCAATGGACCACAAA       GTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATTTCTAAAACAACTCGGGAGGATGCAGGA       AAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCATATTAGAAATTGGCCA       GAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAGAATCTCTATCACTGC       ATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGTGGTTATGTAGTAGAC       AGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCATTAAAGAAGCAACAGC       TTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACACTGATTACTGTTCCAG       TAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATTGTCACCAGGACAGGG       GCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCACATGGGAGATGCCTGA       CCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGCTTCACTTACAAGGTA       CCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACAGCAAAGAACCCACTT       GGTAGTGATTATGCAGCAACGTATATTCAAGTAATC TGA   CATGAAATAATAAAGTC                                           NOV29ak, SNP13376523   SEQ ID NO:738   2617 aa   MW at 290181.1 kD           of CG55776-01,   SNP Pos: 61       SNP Change:       Protein Sequence           Arg to His                     MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVEHINLGYNS           LVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVRLMVLKMSYNKVRKLQKDTFYGLRSLT       RLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSL       PQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPGIYIVLPDVIKCKKDRSPSSAQQCPLCMNP       RTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEAN       MVCSIQKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSET       PQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEM       RPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKS       GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP       DASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRP       LEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRF       RENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEE       FMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKN       INPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTN       KLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRR       FGRQRKIGGRGRIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATA       ALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTY       APTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTTIAITRFSRRKIPWQQNFVNNH       NPKGRLRNQHKVSLQKSTAVMLPKTSPALPQRQSLPSHHTTTKTHNPGSLPTKKELPFPPLNPMLPSI       ISKDSSTKSIISTQTAIPATTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFT       TPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIA       SETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTNTVVKL       HESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAEN       QFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLS       PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP       VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASS       DRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLP       SKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF       RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE       GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDM       ISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKAT       AVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIPNVRLSDSADFICVARNE       GGESVLVVQLEVLEMLARRPTFAPFNEKIVAQLGKSTAIACSVDGNPPPEIIWILPNGTRFSNGPQSY       QYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHC       VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVM       IVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTL       VIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI                                     NOV29al, SNP13376524 of   SEQ ID NO:739   7876 bP           CG55776-01,   ORF Start: ATG at 6   ORF Stop: TGA at 7857       DNA Sequence   SNP Pos: 251   SNP Change: A to T                       TCAGG   ATG AAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCCTGGTC           GCCACCCCTGGGGGCAAGGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCAC       ATTTCGGTACCTGACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGGTACA       ACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAA   T   CTGGAGTTACTCATGCTTCAC       AGCAATGGCATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTGAGACTGAT       GGTCTTAAAAATGAGCTATAATAAAGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCT       TGACACGATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAAC       TTTCTCCGCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTT       GAGCTACCTCCAGATATTTAAAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCT       CCCTCCCTCAAGAGATGGTCTCCTATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGG       ACCTGTGATTGCCATTTAAAGTGGTTGTCTGACTGGATACAGGAGAAGCCAGGTATCTATATTGTNTT       ACCAGATGTAATAAAATGCAAAAAAGATAGAAGTCCCTCTAGTGCTCAGCAGTGTCCACTTTGCATGA       ACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTGCAGCTTTCCAGTGTGCCAAGCCA       ACCATTGACTCATCCCTGAAATCAAAGAGCCTGACTATTCTGGAAGACAGTAGTTCTGCTTTCATCTC       TCCCCAAGGTTTCATGGCACCCTTTGGCTCCCTCACTTTGAATATGACAGATCAGTCTGGAAATGAAG       CTAACATGGTCTGCAGTATTCAAAAGCCCTCAAGGACATCACCCATTGCATTCACTGAAGAAAATGAC       TACATCGTGCTAAATACTTCATTTTCAACATTTTTGGTGTGCAACATAGATTACGGTCACATTCAGCC       AGTGTGGCAAATTTTGGCTTTGTACAGTGATTCTCCTCTGATACTAGAAAGGAGCCACTTGCTTAGTG       AAACACCGCAGCTCTATTACAAATATAAACAGGTGGCTCCTAAGCCTGAAGACATTTTTACCAACATA       GAGGCAGATCTCAGAGCAGATCCCTCTTGGTTAATGCAAGACCAAATTTCCTTGCAGCTGAACAGAAC       TGCCACCACATTCAGTACATTACAGATCCAGTACTCCAGTGATGCTCAAATCACTTTACCAAGAGCAG       AGATGAGGCCAGTGAAAACACAAATGGACTATGATTTCAAGGGATACAATACTAAGCTGGAACATACT       GTCTTGGTAGGTGGAACCGTTGGCCTGAACTGCCCAGGCCAGGAGACCCCACCCCACAACGTGGATTG       GCTTCTAGCTGATGGAAGTAAAGTGAGAGCCCCTTATGTCAGTGAGGATGGACGGATCCTAATAGACA       AATTATGATGATGCAGATATTCTCACCTATAGGATAACTGTGGTAGAACCTTTGGTCGAAGCCTATCA       GGAAAATGGGATTCATCACACAGTTTTCATTGGTGAAACACTTGATCTTCCATGCCATTCTACTGGTA       TCCCAGATGCCTCTATTAGCTGGGTTATTCCAGGAAACAATGTGCTCTATCAGTCATCAAGAGACAAG       TGTGGCAGCCAACCCATCAGGGGTTGATTTTTTGATTTTCCAAGTTTCAGTCAAGATGAAAGGACAAA       GGCCCTTGGAGCATGATGGAGAAACAGAGGGATCTGGACTTGATGAGTCCAATCCTATTGCTCATCTT       AAGGAGCCACCAGGTGCACAACTCCGTACATCTGCTCTGATGGAGGCTGAGGTTGGAAAACACACCTC       AGCACAGTAAGAGGCACA1ACTATCGGGAAATTAACACTCCAGCGACGTGGAGATTCAACACATCGAC       GTTTTAGGGAGAATAGGAGGCATTTCCCTCCCTCTGCTAGGAGAATTGACCCACAACATTGGGCGGCA       CTGTTGGAGAAAGCTAAAAAGAATGCTATGCCAGACAAGCGAGAAAATACCACAGTGAGCCCACCCCC       AGTGGTCACCCAACTCCCAAACATACCTGGTGAAGAAGACGATTCCTCAGGCATGCTCGCTCTACATG       AGGAATTTATGGTCCCGGCCACTAAAGCTTTGAACCTTCCAGCAAGGACAGTGACTGCTGACTCCAGA       ACAATATCTGATAGTCCTATGACAAACATAAATTATGGCACAGAATTCTCTCCTGTTGTGAATTCACA       AATACTACCACCTGAAGAACCCACAGATTTCAAACTGTCTACTGCTATTAAAACTACAGCCATGTCAA       AGAATATAAACCCAACCATGTCAAGCCAAATACAAGGCACAACCAATCAACATTCATCCACTGTCTTT       AAGTAGACCCCCAATAACAGTAAGGACTATGATCAAAGATGTCAATGTCAAAATGCTTAGTAGCACCA       CCAACAAACTATTATTAGAGTCAGTAAATACCACAAATAGTCATCAGACATCTGTAAGAGAAGTGAGT       GAACCCAGGCACAATCACTTCTATTCTCACACTACTCAAATACTTAGCACCTCCACGTTCCCTTCAGA       TCCACACACAGCTGCTCATTCTCAGTTTCCGATCCCTAGAAATAGTACAGTTAACATCCCGCTGTTCA       GACGCTTTGGGAGGCAGAGGAAAATTGGCGGAAGGGGGCGGATTATCAGCCCATATAGAACTCCAGTT       CTGCGACGGCATAGATACAGCATTTTCAGGTCAACAACCAGAGGTTCTTCTGAAAAAAGCACTACTGC       ATTCTCAGCCACAGTGCTCAATGTGACATGTCTGTCCTGTCTTCCCAGGGAGAGGCTCACCACTGCCA       CAGCAGCATTGTCTTTTCCAAGTGCTGCTCCCATCACCTTCCCCAAAGCTGACATTGCTAGAGTCCCA               TCAGAAGAGTCTACAACTCTAGTCCAGAATCCACTATTACTACTTGAGAACAAACCCAGTGTAGAGAA       AACAACACCCACAATAAATATTTCAGGACTGAAATTTCCCAAAGTGACTCCAACTGGTGCAGTCATGA       CATATGCTCCAAACATCCATACCCATGGAAACTCACAAAGTAAACGCCAAGTTACCCAACGTGTGTCT       AGCACCAATGAAGCTAAAAGAGATTCAGTGATTACATCGTCACTTTCAGGTGCTATCACCAAGCCACC       AATGACTATTATAGCCATTACAAGGTTTTCAAGAAGGAAAATTCCCTGGCAACAGAACTTTGTAAATA       ACCATAACCCAAAAGGCAGATTAAGGAATCAACATAAAGTTAGTTTACAAAAAAGCACAGCTGTGATG       CTTCCTAAAACATCTCCTGCTTTACCACAGAGACAAAGTCTCCCCTCGCACCACACTACGACCAAAAC       ACACAATCCTGGAAGTCTTCCAACAAAGAAGGAGCTTCCCTTCCCACCCCTTAACCCTATGCTTCCTA       GTATTATAAGCAAAGACTCAAGTACAAAAGCATCAATATCAACGCAAACAGCAATACCAGCAACAACT       CCTACCTTCCCTGCATCTGTCATCACTTATGACCCAAACAAGAGAGATCTAGAGCACAAAACAATACA       AAGAGAACAGGAGCCTCAAAGAAAGAAkCAGGACTGACCCAACATCTCTCCAGACCAGAGTTCTGGCT       TCACTACACCCACTGCTATGACACCTCCTGTTCTAACCACAGCCGAAACTTCAGTCAAGCCCAGTGTC       TCTGCATTCACTCATTCCCCACCAGAACACAAACTGGGAATTTCAAGCACAATCAGTTTTCATTCAAG       AACTCTTAATCTGACAGATGTGATTGAAGAACTAGCCCAGCAAAGTACTCAGACTTTGAAGAGCACAA       TTGCTTCTGAAACAACTTTGTCCAGCAAATCACACCAGAGTACCACAACTAGGAAAGCAATCATTAGA       CACTCAACCATACCACCATTCTTGAGCAGCAGTGCTACTCTAATGCCAGTTCCCATCTCCCCTCCCTT       TACTCAGAGAGCAGTTACTGACAACGTGGCGACTCCCATTTCCGGGCTTATGACAAATACAGTGGTCA       AGCTGCACGAATCCTCAAGGCACAATGCTAAACCACAGCAATTAGTAGCAGAGGTTGCAACATCCCCC       AAGGTTCACCCAAATGCCAAGTTCACAATTGGAACCACTCACTTCATCTACTCTAATCTGTTACATTC       TACTCCCATGCCAGCACTAACAACAGTTAAATCACAGAATTCTAAATTAACTCCATCTCCCTGGGCAG       AAAACCAATTTTGGCACAAACCATACTCAGAAATTGCTGAAAAAGGCAAAAAGCCAGAAGTAAGCATG       TTGGCTACTACAGGCCTGTCCGAGGCCACCACTCTTGTTTCAGATTGGGATGGACAGAAGAACACAAA       GAAGAGTGACTTTGATAAGAAACCAGTTCAAGAAGCAACAACTTCCAAACTCCTTCCCTTTGACTCTT       TGTCTAGGTATATATTTGAAAAGCCCAGGATAGTTGGAGGAAAAGCTGCAAGTTTTACTATTCCAGCT       AACTCAGATGCCTTTCTTCCCTGTGAAGCTGTTGGAAATCCCCTGCCCACCATTCATTGGACCAGAGT       CCCATCAGGTATGTCAGGACTTGATTTATCTAAGAGGAAACAGAATAGCAGGGTCCAGGTTCTCCCCA       ATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAAT       CTGTTTGGCACAGACCACCTTCATGTCACCTTGTCTGTGGTTTCCTATCCTCCCAGGATCCTGGAGAG       ACGTACCAAGAGATCACAGTTCATTCCGGAAGCACTGTGGAACTGAAGTGCAGAGCAGAAGGTAAGGC       CAAGCCCTACAGTTACCTGGATTCTTGCAAACCAAACAGTTGTCTCAGAATCATCCCAGGGAAGTAGG       CAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTATGACCGTGGCTTTTA       CAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAAATACAAGTCATTGCAGCAC       CACCTGTTATTCTAGAGCATAGGAGGCAAGTCATTGTAGGCACTTGGGGTGAAAGTTTAAAACTGCCC       TGTACTGCAAAAGGAACTCCTCAGCCCAGCGTTTACTGGGTCCTCTCTGATGGCACTGAAGTGAAACC       ATTACAGTTTACCAATTCCAAGTTGTTCTTATTTTCAAATGGGACTTTGTATATAAGAAACCTAGCCT       CTTCAGACAGGGGCACTTATGAATGCATTGCTACCAGTTCCACTGGTTCGGAGCGAAGAGTAGTAATG       CTTACAATGGAAGAGCGAGTGACCAGCCCCAGGATAGAAGCTGCATCCCAGAAAAGGACTGAAGTGAA       TTTTGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGTGGAGGT       GGGGGATGATCTGATACTGATGCATGTTAGCCTAAGACTGAAACCTGCCAAAATTGACCACAAGCAGT       ATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTAGATTGCAAAGCTTCCGGCTCCCCAGTG       CCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAATGCAAGCCGATGACAGTGG       CCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTTTATACTTCAACAAAGTTGGGGTAGCGG       AGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGGAAAAGATGAATGAAGGTCCACTTAACA       GTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAACCAACAAGAGAATCAAAGCTGGAGACAC       AGCTGTCCTTGACTGTGAGGTCACTGGGGATCCCAAACCAAAAATATTTTGGTTGCTGCCTTCCAATG       AAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGATGACACCAAAATGTA               CAAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTCTGTATACAAACAGAACTGTTATTAAAG       CCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACACCATCTCCTGAAGTC       ATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAGAATCACAGTCCATAA       AAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTATCTGTGTGGCCCGAA       ATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTGAGAAGACCGACATTT       AGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATTGAATTGCTCTGTTGA       TGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATGGCACACGATTTTCCAATGGACCACAAA       GTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATTTCTAAAACAACTCGGGAGGATGCAGGA       AAATATCGCTGTGCAGCTAGGAATAA)GTTGGCTATATTGAGAAATTAGTCATATTAGAAATTGGCCA       GAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAGAATCTCTATCACTGC       ATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGTGGTTATGTAGTAGAC       AGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCATTAAAGAAGCAACAGC       TTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACACTGATTACTGTTCCAG       TAATATGATTGTAGCCTACCCTCCCCG1ATTACATCGTCCACCCAGGAGTATTGTCACCAGGACAGGG       GCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCACATGGGAGATGCCTGA       CCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACAGCAAAGAACCCACTT       GGTAGTGATTATGCAGCAACGTATATTCAAGTAATC TGA   CATGAAATAATAAAGTC                                           NOV29al, SNP13376524 of   SEQ ID NO:740   2617 aa   MW at 290186.1 kD           CG55776-01, Protein Sequence   SNP Pos: 82       ISNP Change:                   LYS to ASn                     MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNS           LVRLMETDFSGLT   N   LELLMLHSNGIHTIPDKTFSDLQALQVRIMVLKMSYNKVRKLQKDTFYGLRSLT       RLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSL       PQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPGIYIVLPDVIKCKKDRSPSSAQQCPLCMNP       RTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEAN       MVCSIQKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSET       PQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEM       RPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVPAPYVSEDGRILIDKS       GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP       DASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRP       LEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRF       RENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTNTSPPPVVTQLPNIPGEEDDSSGMLALHEE       FMVPATKALNLPARTVTADSRTISDSPMTNTNYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKN       INPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTN       KLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPPNSTVNIPLFRR       FGRQRKIGGRGRIISPYRTPKTLRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATA       ALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTY       APTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPWQQNFVNNH       NPKGRLRNQHKVSLQKSTAVMLPKTSPALPQRQSLPSHHTTTKTHNPGSLPTKKELPFPPLNPMLPSI       ISKDSSTKSIISTQTAIPATTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFT       TPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIA       SETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTNTVVKL       HESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAEN       QFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKATKKSDFDKKPVQEATTSKLLPFDSLS       RYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGMSGLDLSKRKQNSRVQVLPNG       TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS       PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP       VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASS       DRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLP       SKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF       RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE       GDYTCYAQNTLGKDENKVHLTVITAAPRIRQSNKTAKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDM       ISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKAT       AVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKAGTLEIRNVRLSDSADFICVARNE       GGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSY       QYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHC       VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVM       IVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTL       VIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI                                     NOV29am, SNP13376525 of   SEQ ID NO:741   7876 bP           CG55776-01,   ORF Start: ATG at 6   ORF Stop: TGA at 7857       DNA Sequence   SNP Pos: 493   SNP Change: A to G                       TCAGG   ATG AAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCCTGGTC           GCCACCCCTGGGGGCAAGGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCAC       ATTTCGGTACCTGACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGGTACA       ACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCAC       AGCAATGGCATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTGAGACTGAT       GGTCTTAAAAATGAGCTATAATAAAGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCT       TGACACGATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAAC       TTTCTCCGCCTGGTGC   G   CTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTT       GAGCTACCTCCAGATCTTTAAAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCT       CCCTCCCTCAAGAGATGGTCTCCTATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGG       ACCTGTGATTGCCATTTAAAGTGGTTGTCTGACTGGATACAGGAGAAGCCAGGTATCTATATTGTNTT       ACCAGATGTAATAAATGCAA3AAAAGATAGAAGTCCCTCTAGTGCTCAGCAGTGTCCACTTTGCATGA       ACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTGCAGCTTTCCAGTGTGCCAAGCCA       ACCATTGACTCATCCCTGAAATCAAAGAGCCTGACTATTCTGGAAGACAGTAGTTCTGCTTTCATCTC       TCCCCAAGGTTTCATGGCACCCTTTGGCTCCCTCACTTTGAATATGACAGATCAGTCTGGAAATGAAG       CTAACATGGTCTGCAGTATTCAAAAGCCCTCAAGGACATCACCCATTGCATTCACTGAAGAAAATGAC       TACATCGTGCTAAATACTTCATTTTCAACATTTTTGGTGTGCAACATAGATTACGGTCACATTCAGCC       AGTGTGGCAAATTTTGGCTTTGTACAGTGATTCTCCTCTGATACTAGAAAGGAGCCACTTGCTTAGTG       AAACACCGCAGCTCTATTACAAATATAAACAGGTGGCTCCTAAGCCTGAAGACATTTTTACCAACATA       GAGGCAGATCTCAGAGCAGATCCCTCTTGGTTAATGCAAGACCAAATTTCCTTGCAGCTGAACAGAAC       TGCCACCACATTCAGTACATTACAGATCCAGTACTCCAGTGATGCTCAAATCACTTTACCAAGAGCAG       AGATGAGGCCAGTGAAACACAAATGGACTATGATTTCAAGGGATAACAATACTAAGCTGGAACATACT       GTCTTGGTAGGTGGAACCGTTGGCCTGAACTGCCCAGGCCAAGGAGACCCCACCCCACACGTGGATTG       GCTTCTAGCTGATGGAAGTAAAGTGAGAGCCCCTTATGTCAGTGAGGATGGACGGATCCTAATAGACA       AAAGTGGAAAATTGGAACTCCAGATGGCTGATAGTTTTGACACAGGCGTATATCACTGTATAAGCAGC       AATTATGATGATGCAGATATTCTCACCTATAGGATAACTGTGGTAGAACCTTTGGTCGAAGCCTATCA       GGAAAATGGGATTCATCACACAGTTTTCATTGGTGAAACACTTGATCTTCCATGCCATTCTACTGGTA       TCCCAGATGCCTCTATTAGCTGGGTTATTCCAGGAAACAATGTGCTCTATCAGTCATCAAGAGACAAG       AAAGTTCTAAACAATGGCACATTAAGAATATTACAGGTCACCCCGAAAGACCAAGGTTATTATCGCTG       TGTGGCAGCCAACCCATCAGGGGTTGATTTTTTGATTTTCCAAGTTTCAGTCAAGATGAAAGGACAAA       GGCCCTTGGAGCATGATGGAGAAACAGAGGGATCTGGACTTGATGAGTCCAATCCTATTGCTCATCTT       AAGGAGCCACCAGGTGCACAACTCCGTACATCTGCTCTGATGGAGGCTGAGGTTGGAAAACACACCTC       AAGCACkAGTAAGAGGCACAACTATCGGGAATTAACACTCCAGCGACGTGGAGATTCAACACATCGAC       GTTTTAGGGAGAATAGGAGGCATTTCCCTCCCTCTGCTAGGAGAATTGACCCACAACATTGGGCGGCA       CTGTTGGAGAAAGCTAAAAAGAATGCTATGCCAGACAAGCGAGAAAATACCACAGTGAGCCCACCCCC       AGTGGTCACCCAACTCCCAAACATACCTGGTGAAGAAGACGATTCCTCAGGCATGCTCGCTCTACATG       AGGAATTTATGGTCCCGGCCACTAAAGCTTTGAACCTTCCAGCAAGGACAGTGACTGCTGACTCCAGA       ACAATATCTGATAGTCCTATGACAAACATAAATTATGGCACAGAATTCTCTCCTGTTGTGAATTCACA       AATACTACCACCTGAAGAACCCACAGATTTCAAACTGTCTACTGCTATTAAAACTACAGCCATGTCAA       AGAATATAAACCCAACCATGTCAAGCCAAATACAAGGCACAACCAATCAACATTCATCCACTGTCTTT       CCACTGCTACTTGGAGCAACTGAATTTCAGGACTCTGACCAGATGGGAAGAGGAAGAGAGCATTTCCA       AAGTAGACCCCCAATAACAGTAAGGACTATGATCAAAGATGTCAATGTCAAAATGCTTAGTAGCACCA       CCAACAAACTATTATTAGAGTCAGTAAATACCACAAATAGTCATCAGACATCTGTAAGAGAAGTGAGT       GAACCCAGGCACAATCACTTCTATTCTCACACTACTCAAATACTTAGCACCTCCACGTTCCCTTCAGA       TCCACACACAGCTGCTCATTCTCAGTTTCCGATCCCTAGAAATAGTACAGTTAACATCCCGCTGTTCA       GACGCTTTGGGAGGCAGAGGAAAATTGGCGGAAGGGGGCGGATTATCAGCCCATATAGAACTCCAGTT       CTGCGACGGCATAGATACAGCATTTTCAGGTCAACAACCAGAGGTTCTTCTGAAAAAAGCACTACTGC       ATTCTCAGCCACAGTGCTCAATGTGACATGTCTGTCCTGTCTTCCCAGGGAGAGGCTCACCACTGCCA       CAGCAGCATTGTCTTTTCCAAGTGCTGCTCCCATCACCTTCCCCAAAGCTGACATTGCTAGAGTCCCA               TCAGAAGAGTCTACAACTCTAGTCCAGAATCCACTATTACTACTTGAGAACAAACCCAGTGTAGAGAA       AACAACACCCACAATAAAATATTTCAGGACTGAAATTTCCCAAGTGACTCCAACTGGTGCAGTCATGA       CATATGCTCCAACATCCATACCCATGGAAIAAACTCACAAAGTAAACGCCAGTTACCCACGTGTGTCT       AATGACTATTATAGCCATTACAAGGTTTTCAAGAAGGAAAATTCCCTGGCAACAGAACTTTGTAAATA       ACCATAACCCAAAAGGCAGATTAAGGAATCAACATAAAGTTAGTTTACAAAAAAGCACAGCTGTGATG       CTTCCTAAAACATCTCCTGCTTTACCACAGAGACAAAGTCTCCCCTCGCACCACACTACGACCAAAAC       ACACAATCCTGGAAGTCTTCCAACAAAGAAGGAGCTTCCCTTCCCACCCCTTAACCCTATGCTTCCTA       GTATTATAAGCAAAGACTCAAGTAACAAAGCATCAATATCAACGCAAACAGCAATACCAGCAACAACT       CCTACCTTCCCTGCATCTGTCATCACTTATGAAACCCAAACAGAGAGATCTAGAGCACAAACAATACA       AAGAGAACAGGAGCCTCAAAAGAAGAACAGGACTGACCCAAACATCTCTCCAGACCAGAGTTCTGGCT       TCACTACACCCACTGCTATGACACCTCCTGTTCTAACCACAGCCGAAACTTCAGTCAAGCCCAGTGTC       TCTGCATTCACTCAATTCCCCACCAGAAACACAACTGGGATTTCAAGCACAATCAGTTTTCATTCAAG       TTGCTTCTGAAACAACTTTGTCCAGCAAATCACACCAGAGTACCACAACTAGGAAAGCAATCATTAGA       CACTCAACCATACCACCATTCTTGAGCAGCAGTGCTACTCTAATGCCAGTTCCCATCTCCCCTCCCTT       TACTCAGAGAGCAGTTACTGACAACGTGGCGACTCCCATTTCCGGGCTTATGACAAATACAGTGGTCA       AGCTGCACGAATCCTCAAGGCACAATGCTAAACCACAGCAATTAGTAGCAGAGGTTGCAACATCCCCC       AAGGTTCACCCAAATGCCAAGTTCACAATTGGAACCACTCACTTCATCTACTCTAATCTGTTACATTC       TACTCCCATGCCAGCACTAACAACAGTTAAATCACAGAATTCTAAATTAACTCCATCTCCCTGGGCAG       AAAACCAATTTTGGCACAAACCATACTCAGAAATTGCTGAAAAAGGCAAAAAGCCAGAAGTAAGCATG       TTGGCTACTACAGGCCTGTCCGAGGCCACCACTCTTGTTTCAGATTGGGATGGACAGAAGAACACAAA       GAAGAGTGACTTTGATAAGAAACCAGTTCAAGAAGCAACAACTTCCAAACTCCTTCCCTTTGACTCTT       TGTCTAGGTATATATTTGAAAAGCCCAGGATAGTTGGAGGAAAAGCTGCAAGTTTTACTATTCCAGCT       AACTCAGATGCCTTTCTTCCCTGTGAAGCTGTTGGAAATCCCCTGCCCACCATTCATTGGACCAGAGT       CCCATCAGGTATGTCAGGACTTGATTTATCTAAGAGGAAACAGAATAGCAGGGTCCAGGTTCTCCCCA       ATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAAT       CTGTTTGGCACAGACCACCTTCATGTCACCTTGTCTGTGGTTTCCTATCCTCCCAGGATCCTGGAGAG       ACGTACCAAAGAGATCACAGTTCATTCCGGAAGCACTGTGGAACTGAAGTGCAGAGCAGAAGGTAGGC       CAAGCCCTACAGTTACCTGGATTCTTGCAAACCAAACAGTTGTCTCAGAATCATCCCAGGGAAGTAGG       CAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTATGACCGTGGCTTTTA       CAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAAATACAAGTCATTGCAGCAC       CACCTGTTATTCTAGAGCAAAGGAGGCAAGTCATTGTAGGCACTTGGGGTGAAAGTTTAAAACTGCCC       TGTACTGCAAAAGGAACTCCTCAGCCCAGCGTTTACTGGGTCCTCTCTGATGGCACTGAAGTGAAACC       ATTACAGTTTACCAATTCCAAGTTGTTCTTATTTTCAAATGGGACTTTGTATATAAGAAACCTAGCCT       CTTCAGACAGGGGCACTTATGAATGCATTGCTACCAGTTCCACTGGTTCGGAGCGAAGAGTAGTAATG       CTTACAATGGAAGAGCGAGTGACCAGCCCCAGGATAGAAGCTGCATCCCAGAAAAGGACTGAAGTGAA       TTTTGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGTGGAGGT       TACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGGTGGGCAGCTGGATCCACGTCTACCCTAATGGA       TCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGTCTACTTGTGTGTGGCAAGAAACAAAAT       GGGGGATGATCTGATACTGATGCATGTTAGCCTAAGACTGAAACCTGCCAAAATTGACCACAAGCAGT       ATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTAGATTGCAAAGCTTCCGGCTCCCCAGTG       CCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAATGCAAGCCGATGACAGTGG       CCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTTTATACTTCAACAAAGTTGGGGTAGCGG       AGGAAGGAGATTATACTTGCTATGCCCAGAACAACCCTAAAGGGAAAGATGATGAGGTCCACTTAACA       GTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAACCAACAAGAGAATCAAAGCTGGAGACAC       AGCTGTCCTTGACTGTGAGGTCACTGGGGATCCCAAAACCAAAATATTTTCATTGCTGCCTTCCAATG       ACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCCAATGGGTCTTTGACCATCAACAAAGTG       AAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGATGACACCAAAATGTA               CAACTGGATGTGGTCTCTAAACCTCCATTAATCAAATGGTCTGTATACAAACAGAACTGTTATTAAAG       CCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACACCATCTCCTGAAGTC       ATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAGAATCACAGTCCATAA       AAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTATCTGTGTGGCCCGAA       ATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTGAGAAGACCGACATTT       AGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATTGAATTGCTCTGTTGA       TGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATGGCACACGATTTTCCAATGGACCACAAA       GTTATCAGTATCTGAATAGCAAGCAATGGTTCTTTTATCATTTCTAAACAACTCGGGAGGATGCAGGA       AAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCATATTAGAAATTGGCCA       GAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAGAATCTCTATCACTGC       ATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGTGGTTATGTAGTAGAC       AGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCATTAAAGAAGCAAGAGC       GCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCACATGGGAGATGCCTGA       CCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAGTGAAGCAGCTTCACTTACAAGGTA       CCCTAGTCATTCAGAATCCCCALACCTCCGATTCTGGGATATACAAATGCACAGCAAAGAACCCACTT       GGTAGTGATTATGCAGCAACGTATATTCAAGTAAAATCTGACA TGA   ATAATAAAGTC                                           NOV29am, SNP13376525 of   SEQ ID NO:742   2617 aa   MW at 290219.2 kD           CG55776-01, Protein Sequence   SNP Pos: 163       SNP Change: His to Arg                     MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNS           LVRLMETDFSGLTKLELLMLHSNGIHTPDKTFSDLQALQVRLMVLKMSYIAKVRKLQKDTFYGLRSLT       RLHMDHNNIEFINPEVFYGLNFLRLV   R   LEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSL       PQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPGIYIVLPDVIKCKKDRSPSSAQQCPLCMNP       RTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEAN       PQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEM       RPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVPAPYVSEDGRILIDKS       GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP       DASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRP       LEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRF       RENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEE       FMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKN       INPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKNLSSTTN       KLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRR       FGRQRKIGGRGRIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATA       ALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTY       APTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPWQQNFVNNH       ISKDSSTKSIISTQTAIPATTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFT       TPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIA       SETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQEAVTDNVATPISGLMTNTVVKL       HESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAEN       QFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLS       RYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGMSGLDLSKRKQNSRVQVLPNG       TLSQRVEIQDRGQYLCSASNLFGTDHLHVTLSKTVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS       PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP       VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASS       DRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLP       SKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF       RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE       GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDM       ISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKAT       AVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE       GGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSY       QYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHC       VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVM       IVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTL       VIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI                             NOV29an, SNP13376526   SEQ ID NO:743   7876 bP           of CG55776-01,   ORF Start: ATG at 6   ORF Stop: TGA at 7857       DNA Sequence   SNP Pos: 547   SNP Change: G to A                       TCAGG   ATG AAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCCTGGTC           GCCACCCCTGGGGGCAAGGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCAC       ATTTCGGTACCTGACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGGTACA       ACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCAC       AGCAATGGCATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTGAGACTGAT       GGTCTTAAAAATGAGCTATAATAAAGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCT       TGACACGATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAAC       TTTCTCCGCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTT       GAACTACCTCCAGATATTTAAAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCT       CCCTCCCTCAAGAGATGGTCTCCTATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGG       ACCTGTGATTGCCATTTAAAGTGGTTGTCTGACTGGATACAGGAGAAGCCAGGTATCTATATTGTNTT       ACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTGCAGCTTTCCAGTGTGCCAAGCCA       ACCATTGACTCATCCCTGAAATCAAAGAGCCTGACTATTCTGGAAGACAGTAGTTCTGCTTTCATCTC       TCCCCAAGGTTTCATGGCACCCTTTGGCTCCCTCACTTTGAATATGACAGATCAGTCTGGAAATGAAG       CTAACATGGTCTGCAGTATTCAAAAGCCCTCAAGGACATCACCCATTGCATTCACTGAAGAAAATGAC       TACATCGTGCTAAATACTTCATTTTCAACATTTTTGGTGTGCAACATAGATTACGGTCACATTCAGCC       AGTGTGGCAAATTTTGGCTTTGTACAGTGATTCTCCTCTGATACTAGAAAGGAGCCACTTGCTTAGTG       AAACACCGCAGCTCTATTACAAATATAAACAGGTGGCTCCTAAGCCTGAAGACATTTTTACCAACATA       GAGGCAGATCTCAGAGCAGATCCCTCTTGGTTAATGCAAGACCAAATTTCCTTGCAGCTGAACAGAAC       TGCCACCACATTCAGTACATTACAGATCCAGTACTCCAGTGATGCTCAAATCACTTTACCAAGAGCAG       AGATGAGGCCAGTGAAACACAAATGGACTATGATTTCAAGGGATAACAATACTAAGCTGGAACATACT       GTCTTGGTAGGTGGAACCGTTGGCCTGAACTGCCCAGGCCAAGGAGACCCCACCCCACACGTGGATTG       GCTTCTAGCTGATGGAAGTAAAGTGAGAGCCCCTTATGTCAGTGAGGATGGACGGATCCTAATAGACA       AAAGTGGAAAATTGGAACTCCAGATGGCTGATAGTTTTGACACAGGCGTATATCACTGTATAAGCAGC       AATTATGATGATGCAGATATTCTCACCTATAGGATAACTGTGGTAGAACCTTTGGTCGAAGCCTATCA       GGAAAATGGGATTCATCACACAGTTTTCATTGGTGAAACACTTGATCTTCCATGCCATTCTACTGGTA       AAAGTTCTAAACAATGGCACATTAAGAATATTACAGGTCACCCCGAAAGACCAAGGTTATTATCGCTG       TGTGGCAGCCAACCCATCAGGGGTTGATTTTTTGATTTTCCAAGTTTCAGTCAAGATGAAAGGACAAA       GGCCCTTGGAGCATGATGGAGAAACAGAGGGATCTGGACTTGATGAGTCCAATCCTATTGCTCATCTT       AAGGAGCCACCAGGTGCACAACTCCGTACATCTGCTCTGATGGAGGCTGAGGTTGGAAAACACACCTC       AAGCACAAGTAAGAGGCACAACTATCGGGAATTAACACTCCAGCGACGTGGAGATTCAACACATCGAC       GTTTTAGGGAGAATAGGAGGCATTTCCCTCCCTCTGCTAGGAGAATTGACCCACAACATTGGGCGGCA       CTGTTGGAGAAAGCTAAAAAGAATGCTATGCCAGACAAGCGAGAAAATACCACAGTGAGCCCACCCCC       AGTGGTCACCCAACTCCCAAACATACCTGGTGAAGAAGACGATTCCTCAGGCATGCTCGCTCTACATG       AGGAATTTATGGTCCCGGCCACTAAAGCTTTGAACCTTCCAGCAAGGACAGTGACTGCTGACTCCAGA       ACAATATCTGATAGTCCTATGACAAACATAAATTATGGCACAGAATTCTCTCCTGTTGTGAATTCACA       AATACTACCACCTGAAGAACCCACAGATTTCAAACTGTCTACTGCTATTAAAACTACAGCCATGTCAA       AGAATATAAACCCAACCATGTCAAGCCAAATACAAGGCACAACCAATCAACATTCATCCACTGTCTTT       CCACTGCTACTTGGAGCAACTGAATTTCAGGACTCTGACCAGATGGGAAGAGGAAGAGAGCATTTCCA       AAGTAGACCCCCAATAACAGTAAGGACTATGATCAAAGATGTCAATGTCAAAATGCTTAGTAGCACCA       CCAACAAACTATTATTAGAGTCAGTAAATACCACAAATAGTCATCAGACATCTGTAAGAGAAGTGAGT       GAACCCAGGCACAATCACTTCTATTCTCACACTACTCAAATACTTAGCACCTCCACGTTCCCTTCAGA       TCCACACACAGCTGCTCATTCTCAGTTTCCGATCCCTAGAAATAGTACAGTTAACATCCCGCTGTTCA       GACGCTTTGGGAGGCAGAGGAAAATTGGCGGAAGGGGGCGGATTATCAGCCCATATAGAACTCCAGTT       CTGCGACGGCATAGATACAGCATTTTCAGGTCAACAACCAGAGGTTCTTCTGAAAAAAGCACTACTGC       ATTCTCAGCCACAGTGCTCAATGTGACATGTCTGTCCTGTCTTCCCAGGGAGAGGCTCACCACTGCCA       CAGCAGCATTGTCTTTTCCAAGTGCTGCTCCCATCACCTTCCCCAAAGCTGACATTGCTAGAGTCCCA               TCAGAAGAGTCTACAACTCTAGTCCAGAATCCACTATTACTACTTGAGAACAAACCCAGTGTAGAGAA       AACAACACCCACAATAAAATATTTCAGGACTGAAATTTCCCAAGTGACTCCAACTGGTGCAGTCATGA       CATATGCTCCAACATCCATACCCATGGAAAAAACTCACAAAGTAAACGCCAGTTACCCACGTGTGTCT       AGCACCAATGAAGCTAAAAGAGATTCAGTGATTACATCGTCACTTTCAGGTGCTATCACCAAGCCACC       AATGACTATTATAGCCATTACAAGGTTTTCAAGAAGGAAAATTCCCTGGCAACAGAACTTTGTAAATA       ACCATAACCCAAAAGGCAGATTAAGGAATCAACATAAAGTTAGTTTACAAAAAAGCACAGCTGTGATG       CTTCCTAAAACATCTCCTGCTTTACCACAGAGACAAAGTCTACCCTCGCACCACACTACGACCAAAAC       ACACAATCCTGGAAGTCTTCCAACAAAGAAGGAGCTTCCCTTCCCACCCCTTAACCCTATGCTTCCTA       GTATTATAAGCAAAGACTCAAGTACAAAAAGCATCATATCAACGCAAACAGCAATACCAGCAACAACT       CCTACCTTCCCTGCATCTGTCATCACTTATGAAACCCAAACAGAGAGATCTAGAGCACAAACAATACA       AAGAGAACAGGAGCCTCAAAAGAAGAACAGGACTGACCCAAACATCTCTCCAGACCAGAGTTCTGGCT       TCACTACACCCACTGCTATGACACCTCCTGTTCTAACCACAGCCGAAACTTCAGTCAAGCCCAGTGTC       TCTGCATTCACTCATTCCCCACCAGAAAACACAACTGGGATTTCAAGCACAATCAGTTTTCATTCAAG       AACTCTTAATCTGACAGATGTGATTGAAGAACTAGCCCAAGCAAGTACTCAGACTTTGAAGAGCACAA       TTGCTTCTGAAACAACTTTGTCCAGCAAATCACACCAGAGTACCACAACTAGGAAAGCAATCATTAGA       CACTCAACCATACCACCATTCTTGAGCAGCAGTGCTACTCTAATGCCAGTTCCCATCTCCCCTCCCTT       TACTCAGAGAGCAGTTACTGACAACGTGGCGACTCCCATTTCCGGGCTTATGACAAATACAGTGGTCA       AGCTGCACGAATCCTCAAGGCACAATGCTAAACCACAGCAATTAGTAGCAGAGGTTGCAACATCCCCC       AAGGTTCACCCAAATGCCAAGTTCACAATTGGAACCACTCACTTCATCTACTCTAATCTGTTACATTC       TACTCCCATGCCAGCACTAACAACAGTTAAATCACAGAATTCTAAATTAACTCCATCTCCCTGGGCAG       AAAACCAATTTTGGCACAAACCATACTCAGAAATTGCTGAAAAAGGCAAAAAGCCAGAAGTAAGCATG       TTGGCTACTACAGGCCTGTCCGAGGCCACCACTCTTGTTTCAGATTGGGATGGACAGAAGAACACAAA       GAAGAGTGACTTTGATAAGAAACCAGTTCAAGAAGCAACAACTTCCAAACTCCTTCCCTTTGACTCTT       TGTCTAGGTATATATTTGAAAAGCCCAGGATAGTTGGAGGAAAAGCTGCAAGTTTTACTATTCCAGCT       AACTCAGATGCCTTTCTTCCCTGTGAAGCTGTTGGAAATCCCCTGCCCACCATTCATTGGACCAGAGT       CCCATCAGGTATGTCAGGACTTGATTTATCTAAGAGGAAACAGAATAGCAGGGTCCAGGTTCTCCCCA       ATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAAT       CTGTTTGGCACAGACCACCTTCATGTCACCTTGTCTGTGGTTTCCTATCCTCCCAGGATCCTGGAGAG       ACGTACCAAAGAGATCACAGTTCATTCCGGAAGCACTGTGGAACTGAAGTGCAGAGCAGAAGGTAGGC       CAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTATGACCGTGGCTTTTA       CAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAAATACAAGTCATTGCAGCAC       CACCTGTTATTCTAGAGCAAAGGAGGCAAGTCATTGTAGGCACTTGGGGTGAAAGTTTAAAACTGCCC       TGTACTGCAAAAGGAACTCCTCAGCCCAGCGTTTACTGGGTCCTCTCTGATGGCACTGAAGTGAAACC       ATTACAGTTTACCAATTCCAAGTTGTTCTTATTTTCAAATGGGACTTTGTATATAAGAAACCTAGCCT       CTTCAGACAGGGGCACTTATGAATGCATTGCTACCAGTTCCACTGGTTCGGAGCGAAGAGTAGTAATG       CTTACAATGGAAGAGCGAGTGACCAGCCCCAGGATAGAAGCTGCATCCCAGAAAAGGACTGAAGTGAA       TTTTGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGTGGAGGT       TACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGGTGGGCAGCTGGATCCACGTCTACCCTAATGGA       TCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGTCTACTTGTGTGTGGCAAGAAACAAAAT       GGGGGATGATCTGATACTGATGCATGTTAGCCTAAGACTGAAACCTGCCAAAATTGACCACAAGCAGT       ATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTAGATTGCAAAGCTTCCGGCTCCCCAGTG       CCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAATGCAAGCCGATGACAGTGG       CCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTTTATACTTCAACAAAGTTGGGGTAGCGG       AGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGGAAAGATGAAATGAAGGTCCACTTAACA       GTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAACCAACAAGAGAATCAAAGCTGGAGACAC       AGCTGTCCTTGACTGTGAGGTCACTGGGGATCCCAAACCAAAAATATTTTGGTTGCTGCCTTCCAATG       ACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCCAATGGGTCTTTGACCATCAACAAAGTG       AAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGATGACACCAAAATGTA               CAAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTCTGTATACAAACAGAACTGTTATTAAAG       CCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACACCATCTCCTGAAGTC       ATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAGAATCACAGTCCATAA       AAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTATCTGTGTGGCCCGAA       ATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTGAGAAGACCGACATTT       AGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATTGAATTGCTCTGTTGA       TGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATGGCACACGATTTTCCAATGGACCACAAA       GTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATTTCTAAAACAACTCGGGAGGATGCAGGA       AAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCATATTAGAAATTGGCCA       GAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAGAATCTCTATCACTGC       ATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGTGGTTATGTAGTAGAC       AGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCATTAAAGAAGCAACAGC       TTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACACTGATTACTGTTCCAG       TAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATTGTCACCAGGACAGGG       GCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCACATGGGAGATGCCTGA       CCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGCTTCACTTACAAGGTA       CCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACAGCAAAGAACCCACTT       GGTAGTGATTATGCAGCAACGTATATTCAAGTAATC TGA   CATGAAATAATAAAGTC                                           NOV29an, SNP13376526 of   SEQ ID NO:744   2617 aa   MW at 290227.2 kD           CG55776-01,   SNP Pos: 181       SNP Change:       Protein Sequence           Ser to Asn                     MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSTPDSIPPNVERINLGYNS           LVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVRLMVLKMSYNKVRKLQKDTFYGLRSLT       RLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSL   N   YLQIFKISFIKFLYLSDNFLTSL       PQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPGIYIVLPDVIKCKKDRSPSSAQQCPLCMNP       RTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEAN       MVCSIQKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSET       PQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEM       RPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKS       GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP       DASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRP       LEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRF       RENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEE       FMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKN       INPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTN       KLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRR       FGRQRKIGGRGRIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATA       ALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTY       APTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPWQQNFVNNH       NPKGRLRNQHKVSLQKSTAVMLPKTSPALPQRQSLPSHHTTTKTHNPGSLPTKKELPFPPLNPMLPSI       ISKDSSTKSIISTQTAIPATTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFT       TPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIA       SETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTNTVVKL       HESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAEN       QFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLS       RYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGMSGLDLSKRKQNSRVQVLPNG       TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS       PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP       VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASS       DRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLP       SKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVAAAKMGDDLILMHVSLRLKPAKIDHKQYF       RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE       GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDM       ISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKAT       AVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE       GGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSY       QYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHC       VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVM       IVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTL       IVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI                                     NOV29ao, SNP13377626   SEQ ID NO:745   7876 bP           of CG55776-01,   ORF Start: ATG at 6   ORF Stop: TGA at 7857       DNA Sequence   SNP Pos: 4405   SNP Change: C to T                       TCAGG   ATG AAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCCTGGTC           GCCACCCCTGGGGGCAAGGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCAC       ATTTCGGTACCTGACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGGTACA       ACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCAC       AGCAATGGCATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTGAGACTGAT       TGACACGATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAAC       TTTCTCCGCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTT       GAGCTACCTCCAGATATTTAAAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCT       CCCTCCCTCAAGAGATGGTCTCCTATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGG       ACCTGTGATTGCCATTTAAAGTGGTTGTCTGACTGGATACAGGAGAAGCCAGGTATCTATATTGTNTT       ACCAGATGTAAAAAAATGCAAAAAAGATAGAAGTCCCTCTAGTGCTCAGCAGTGTCCACTTTGCATGA       ACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTGCAGCTTTCCAGTGTGCCAAGCCA       ACCATTGACTCATCCCTGAAATCAAAGAGCCTGACTATTCTGGAAGACAGTACTTCTGCTTTCATCTC       TCCCCAAGGTTTCATGGCACCCTTTGGCTCCCTCACTTTGAATATGACAGATCAGTCTGGAAATGAAG       CTAACATGGTCTGCAGTATTCAAAAGCCCTCAAGGACATCACCCATTGCATTCACTGAAGAAAATGAC       TACATCGTGCTAAATACTTCATTTTCAACATTTTTGGTGTGCAACATAGATTACGGTCACATTCAGCC       AGTGTGGCAAATTTTGGCTTTGTACAGTGATTCTCCTCTGATACTAGAAAGGAGCCACTTGCTTAGTG       AAACACCGCAGCTCTATTACAAATATAAACAGGTGGCTCCTAAGCCTGAAGACATTTTTACCAACATA       GAGGCAGATCTCAGAGCAGATCCCTCTTGGTTAATGCAAGACCAAATTTCCTTGCAGCTGAACAGAAC       TGCCACCACATTCAGTACATTACAGATCCAGTACTCCAGTGATGCTCAAATCACTTTACCAAGAGCAG       AGATGAGGCCAGTGAAACACAAATGGACTATGATTTCAAGGGATAACAATACTAAGCTGGAACATACT       GTCTTGGTAGGTGGAACCGTTGGCCTGAACTGCCCAGGCCAAGGAGACCCCACCCCACACGTGGATTG       GCTTCTAGCTGATGGAAGTAAAGTGAGAGCCCCTTATGTCAGTGAGGATGGACGGATCCTAATAGACA       AAAGTGGAAAATTGGAACTCCAGATGGCTGATAGTTTTGACACAGGCGTATATCACTGTATAAGCAGC       AATTATGATGATGCAGATATTCTCACCTATAGGATAACTGTGGTAGAACCTTTGGTCGAAGCCTATCA       GGAAAATGGGATTCATCACACAGTTTTCATTGGTGAAACACTTGATCTTCCATGCCATTCTACTGGTA       TCCCAGATGCCTCTATTAGCTGGGTTATTCCAGGAAACAATGTGCTCTATCAGTCATCAAGAGACAAG       AAAGTTCTAAACAATGGCACATTAAGAATATTACAGGTCACCCCGAAAGACCAAGGTTATTATCGCTG       TGTGGCAGCCAACCCATCAGGGGTTGATTTTTTGATTTTCCAAGTTTCAGTCAAGATGAAAGGACAAA       GGCCCTTGGAGCATGATGGAGAAACAGAGGGATCTGGACTTGATGAGTCCAATCCTATTGCTCATCTT       AAGGAGCCACCAGGTGCACAACTCCGTACATCTGCTCTGATGGAGGCTGAGGTTGGAAAACACACCTC       AAGCACAAGTAAGAGGCACAACTATCGGGAATTAACACTCCAGCGACGTGGAGATTCAACACATCGAC       GTTTTAGGGAGAATAGGAGGCATTTCCCTCCCTCTGCTAGGAGAATTGACCCACAACATTGGGCGGCA       CTGTTGGAGAAAGCTAAAAAGAATGCTATGCCAGACAAGCGAGAAAATACCACAGTGAGCCCACCCCC       AGTGGTCACCCAACTCCCAAACATACCTGGTGAAGAAGACGATTCCTCAGGCATGCTCGCTCTACATG       AGGAATTTATGGTCCCGGCCACTAAAGCTTTGAACCTTCCAGCAAGGACAGTGACTGCTGACTCCAGA       ACAATATCTGATAGTCCTATGACAAACATAAATTATGGCACAGAATTCTCTCCTGTTGTGAATTCACA       AATACTACCACCTGAAGAACCCACAGATTTCAAACTGTCTACTGCTATTAAAACTACAGCCATGTCAA       AGAATATAAACCCAACCATGTCAAGCCAAATACAAGGCACAACCAATCAACATTCATCCACTGTCTTT       CCACTGCTACTTGGAGCAACTGAATTTCAGGACTCTGACCAGATGGGAAGAGGAAGAGAGCATTTCCA       AAGTAGACCCCCAATAACAGTAAGGACTATGATCAAAGATGTCAATGTCAAAATGCTTAGTAGCACCA       CCAACAAACTATTATTAGAGTCAGTAAATACCACAAATAGTCATCAGACATCTGTAAGAGAAGTGAGT       GAACCCAGGCACAATCACTTCTATTCTCACACTACTCAAATACTTAGCACCTCCACGTTCCCTTCAGA       TCCACACACAGCTGCTCATTCTCAGTTTCCGATCCCTAGAAATAGTACAGTTAACATCCCGCTGTTCA       GACGCTTTGGGAGGCAGAGGAAAATTGGCGGAAGGGGGCGGATTATCAGCCCATATAGAACTCCAGTT       CTGCGACGGCATAGATACAGCATTTTCAGGTCAACAACCAGAGGTTCTTCTGAAAAAAGCACTACTGC       ATTCTCAGCCACAGTGCTCAATGTGACATGTCTGTCCTGTCTTCCCAGGGAGAGGCTCACCACTGCCA       CAGCAGCATTGTCTTTTCCAAGTGCTGCTCCCATCACCTTCCCCAAAGCTGACATTGCTAGAGTCCCA               TCAGAAGAGTCTACAACTCTAGTCCAGAATCCACTATTACTACTTGAGAACAAACCCAGTGTAGAGAA       AACAACACCCACAATAAAATATTTCAGGACTGAAATTTCCCAAGTGACTCCAACTGGTGCAGTCATGA       CATATGCTCCAACATCCATACCCATGGAAAAAACTCACAAAGTAAACGCCAGTTACCCACGTGTGTCT       AATGACTATTATAGCCATTACAAGGTTTTCAAGAAGGAAAATTCCCTGGCAACAGAACTTTGTAAATA       ACCATAACCCAAAAGGCAGATTAAGGAATCAACATAAAGTTAGTTTACAAAAAAGCACAGCTGTGATG       CTTCCTAAAACATCTCCTGCTTTACCACAGAGACAAAGTCTCCCCTCGCACCACACTACGACCAAAAC       ACACAATCCTGGAAGTCTTCCAACAAAGAAGGAGCTTCCCTTCCCACCCCTTAACCCTATGCTTCCTA       GTATTATAAGCAAAGACTCAAGTACAAAAAGCATCATATCAACGCAAACAGCAATACCAGCAACAACT       CCTACCTTCCCTGCATCTGTCATCACTTATGAAACCCAAACAGAGAGATCTAGAGCACAAACAATACA       AAGAGAACAGGAGCCTCAAAAGAAGAACAGGACTGACCCAAACATCTCTCCAGACCAGAGTTCTGGCT       TCACTACACCCACTGCTATGACACCTCCTGTTCTAACCACAGCCGAAACTTCAGTCAAGCCCAGTGTC       TCTGCATTCACTCATTCCCCACCAGAAAACACAACTGGGATTTCAAGCACAATCAGTTTTCATTCAAG       AACTCTTAATCTGACAGATGTGATTGAAGAACTAGCCCAAGCAAGTACTCAGACTTTGAAGAGCACAA       TTGCTTCTGAAACAACTTTGTCCAGCAAATCACACCAGAGTACCACAACTAGGAAAGCAATCATTAGA       CACTCAACCATACCACCATTCTTGAGCAGCAGTGCTACTCTAATGCCAGTTC   T   CATCTCCCCTCCCTT       TACTCAGAGAGCAGTTACTGACAACGTGGCGACTCCCATTTCCGGGCTTATGACAAATACAGTGGTCA       AGCTGCACGAATCCTCAAGGCACAATGCTAAACCACAGCAATTAGTAGCAGAGGTTGCAACATCCCCC       AAGGTTCACCCAAATGCCAAGTTCACAATTGGAACCACTCACTTCATCTACTCTAATCTGTTACATTC       AAAACCAATTTTGGCACAAACCATACTCAGAAATTGCTGAAAAAGGCAAAAAGCCAGAAGTAAGCATG       TTGGCTACTACAGGCCTGTCCGAGGCCACCACTCTTGTTTCAGATTGGGATGGACAGAAGAACACAAA       GAAGAGTGACTTTGATAAGAAACCAGTTCAAGAAGCAACAACTTCCAAACTCCTTCCCTTTGACTCTT       CCCATCAGGTATGTCAGGACTTGATTTATCTAAGAGGAAACAGAATAGCAGGGTCCAGGTTCTCCCCA       ATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAAT       CTGTTTGGCACAGACCACCTTCATGTCACCTTGTCTGTGGTTTCCTATCCTCCCAGGATCCTGGAGAG       ACGTACCAAAGAGATCACAGTTCATTCCGGAAGCACTGTGGAACTGAAGTGCAGAGCAGAAGGTAGGC       CAAGCCCTACAGTTACCTGGATTCTTGCAAACCAAACAGTTGTCTCAGAATCATCCCAGGGAAGTAGG       CAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTATGACCGTGGCTTTTA                       CAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAAATACAAGTCATTGCAGCAC       CACCTGTTATTCTAGAGCAAAGGAGGCAAGTCATTGTAGGCACTTGGGGTGAAAGTTTAAAACTGCCC       TGTACTGCAAAAGGAACTCCTCAGCCCAGCGTTTACTGGGTCCTCTCTGATGGCACTGAAGTGAAACC       ATTACAGTTTACCAATTCCAAGTTGTTCTTATTTTCAAATGGGACTTTGTATATAAGAAACCTAGCCT       CTTCAGACAGGGGCACTTATGAATGCATTGCTACCAGTTCCACTGGTTCGGAGCGAAGAGTAGTAATG       CTTACAATGGAAGAGCGAGTGACCAGCCCCAGGATAGAAGCTGCATCCCAGAAAAGGACTGAAGTGAA       TTTTGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGTGGAGGT       TACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGGTGGGCAGCTGGATCCACGTCTACCCTAATGGA       TCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGTCTACTTGTGTGTGGCAAGAAACAAAAT       GGGGGATGATCTGATACTGATGCATGTTAGCCTAAGACTGAAACCTGCCAAAATTGACCACAAGCAGT       ATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTAGATTGCAAAGCTTCCGGCTCCCCAGTG       CCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAATGCAAGCCGATGACAGTGG       CCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTTTATACTTCAACAAAGTTGGGGTAGCGG       AGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGGAAAGATGAAATGAAGGTCCACTTAACA       GTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAACCAACAAGAGAATCAAAGCTGGAGACAC       AGCTGTCCTTGACTGTGAGGTCACTGGGGATCCCAAACCAAAAATATTTTGGTTGCTGCCTTCCAATG       ACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCCAATGGGTCTTTGACCATCAACAAAGTG       AAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGATGACACCAAAATGTA               CAAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTCTGTATACAAACAGAACTGTTATTAAAG       CCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACACCATCTCCTGAAGTC       ATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAGAATCACAGTCCATAA       AAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTATCTGTGTGGCCCGAA       ATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTGAGAAGACCGACATTT       AGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATTGAATTGCTCTGTTGA       TGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATGGCACACGATTTTCCAATGGACCACAAA       GTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATTTCTAAAACAACTCGGGAGGATGCAGGA       AAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCATATTAGAAATTGGCCA       GAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAGAATCTCTATCACTGC       ATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGTGGTTATGTAGTAGAC       AGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCATTAAAGAAGCAACAGC       TTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACACTGATTACTGTTCCAG       TAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATTGTCACCAGGACAGGG       GCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCACATGGGAGATGCCTGA       CCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGCTTCACTTACAAGGTA       CCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACAGCAAAGAACCCACTT       GGTAGTGATTATGCAGCAACGTATATTCAAGTAATCTQACATGAAATAATAAAGTC                                         NOV29ao, SNP13377626 of   SEQ ID NO:746   2617 aa   MW at 290216.2 kD           CG55776-01, Protein Sequence   SNP Pos: 1467       SNP Change: Pro to Leu                     MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNS           LVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVRLMVLKMSYNKVRKLQKDTFYGLRSLT       RLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSL       RTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFTSPQGFMAPFGSLTLNNTDQSGNEAN       MVCSIQKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSET       PQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEM       RPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKS       GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP       DASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRP       LEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRF       RENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEE       FMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKN       KLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRR       FGRQRKIGGRGRIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATA       ALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTY       APTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPWQQNFVNNH       NPKGRLRNQHKVSLQKSTAVMLPKTSPALPQRQSLPSHHTTTKTHNPGSLPTKKELPFPPLNPMLPSI       ISKDSSTKSIISTQTAIPATTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFT       TPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIA       SETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPV   L   ISPPFTQRAVTDNVATPISGLMTNTVVKL       HESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAEN       QFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLS       RYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGMSGLDLSKRKQNSRVQVLPNG       TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS       PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP       VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASS       DRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLP       SKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF       RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE       GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDM       ISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKAT       AVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE       GGESVLVVQLEVLEMLRRTFRNPFNIEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSY       QYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHC       VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVM       IVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTL       VIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI                                     NOV29ap, SNP13377641   SEQ ID NO:747   7876 bP           of CG55776-01,   ORF Start: ATG at 6   ORF Stop: TGA at 7857       DNA Sequence           SNP Pos: 6716 ISNP Change: C to T                       TCAGG   ATG AAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCCTGGTC           GCCACCCCTGGGGGCAAGGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCAC       ATTTCGGTACCTGACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGGTACA       ACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCAC       AGCAATGGCATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTGAGACTGAT       GGTCTTAAAAATGAGCTATAATAAAGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCT       TGACACGATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAAC       TTTCTCCGCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTT       GAGCTACCTCCAGATATTTAAAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCT       CCCTCCCTCAAGAGATGGTCTCCTATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGG       ACCTGTGATTGCCATTTAAAGTGGTTGTCTGACTGGATACAGGAGAAGCCAGGTATCTATATTGTNTT       ACCAGATGTAATAAAATGCAAAAAAGATAGAAGTCCCTCTAGTGCTCAGCAGTGTCCACTTTGCATGA       ACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTGCAGCTTTCCAGTGTGCCAAGCCA       ACCATTGACTCATCCCTGAAATCAAAGAGCCTGACTATTCTGGAAGACAGTAGTTCTGCTTTCATCTC       TCCCCAAGGTTTCATGGCACCCTTTGGCTCCCTCACTTTGAATATGACAGATCAGTCTGGAAATGAAG       CTAACATGGTCTGCAGTATTCAAAAGCCCTCAAGGACATCACCCATTGCATTCACTGAAGAAAATGAC       TACATCGTGCTAAATACTTCATTTTCAACATTTTTGGTGTGCAACATAGATTACGGTCACATTCAGCC       AGTGTGGCAAATTTTGGCTTTGTACAGTGATTCTCCTCTGATACTAGAAAGGAGCCACTTGCTTAGTG       AAACACCGCAGCTCTATTACAAATATAAACAGGTGGCTCCTAAGCCTGAAGACATTTTTACCAACATA       GAGGCAGATCTCAGAGCAGATCCCTCTTGGTTAATGCAAGACCAAATTTCCTTGCAGCTGAACAGAAC       TGCCACCACATTCAGTACATTACAGATCCAGTACTCCAGTGATGCTCAAATCACTTTACCAAGAGCAG       AGATGAGGCCAGTGAAACACAAATGGACTATGATTTCAAGGGATAACAATACTAAGCTGGAACATACT       GTCTTGGTAGGTGGAACCGTTGGCCTGAACTGCCCAGGCCAAGGAGACCCCACCCCACACGTGGATTG       GCTTCTAGCTGATGGAAGTAAAGTGAGAGCCCCTTATGTCAGTGAGGATGGACGGATCCTAATAGACA       AAAGTGGAAAATTGGAACTCCAGATGGCTGATAGTTTTGACACAGGCGTATATCACTGTATAAGCAGC       AATTATGATGATGCAGATATTCTCACCTATAGGATAACTGTGGTAGAACCTTTGGTCGAAGCCTATCA       GGAAAATGGGATTCATCACACAGTTTTCATTGGTGAAACACTTGATCTTCCATGCCATTCTACTGGTA       TCCCAGATGCCTCTATTAGCTGGGTTATTCCAGGAAACAATGTGCTCTATCAGTCATCAAGAGACAAG       AAAGTTCTAAACAATGGCACATTAAGAATATTACAGGTCACCCCGAAAGACCAAGGTTATTATCGCTG       TGTGGCAGCCAACCCATCAGGGGTTGATTTTTTGATTTTCCAAGTTTCAGTCAAGATGAAAGGACAAA       GGCCCTTGGAGCATGATGGAGAAACAGAGGGATCTGGACTTGATGAGTCCAATCCTATTGCTCATCTT       AAGGAGCCACCAGGTGCACAACTCCGTACATCTGCTCTGATGGAGGCTGAGGTTGGAAAACACACCTC       AAGCACAAGTAAGAGGCACAACTATCGGGAATTAACACTCCAGCGACGTGGAGATTCAACACATCGAC       GTTTTAGGGAGAATAGGAGGCATTTCCCTCCCTCTGCTAGGAGAATTGACCCACAACATTGGGCGGCA       CTGTTGGAGAAAGCTAAAAAGAATGCTATGCCAGACAAGCGAGAAAATACCACAGTGAGCCCACCCCC       AGTGGTCACCCAACTCCCAAACATACCTGGTGAAGAAGACGATTCCTCAGGCATGCTCGCTCTACATG       AGGAATTTATGGTCCCGGCCACTAAAGCTTTGAACCTTCCAGCAAGGACAGTGACTGCTGACTCCAGA       ACAATATCTGATAGTCCTATGACAAACATAAATTATGGCACAGAATTCTCTCCTGTTGTGAATTCACA       AATACTACCACCTGAAGAACCCACAGATTTCAAACTGTCTACTGCTATTAAAACTACAGCCATGTCAA       AGAATATAAACCCAACCATGTCAAGCCAAATACAAGGCACAACCAATCAACATTCATCCACTGTCTTT       CCACTGCTACTTGGAGCAACTGAATTTCAGGACTCTGACCAGATGGGAAGAGGAAGAGAGCATTTCCA       AAGTAGACCCCCAATAACAGTAAGGACTATGATCAAAGATGTCAATGTCAAAATGCTTAGTAGCACCA       CCAACAAACTATTATTAGAGTCAGTAAATACCACAAATAGTCATCAGACATCTGTAAGAGAAGTGAGT       GAACCCAGGCACAATCACTTCTATTCTCACACTACTCAAATACTTAGCACCTCCACGTTCCCTTCAGA       TCCACACACAGCTGCTCATTCTCAGTTTCCGATCCCTAGAAATAGTACAGTTAACATCCCGCTGTTCA       GACGCTTTGGGAGGCAGAGGAAAATTGGCGGAAGGGGGCGGATTATCAGCCCATATAGAACTCCAGTT       CTGCGACGGCATAGATACAGCATTTTCAGGTCAACAACCAGAGGTTCTTCTGAAAAAAGCACTACTGC       ATTCTCAGCCACAGTGCTCAATGTGACATGTCTGTCCTGTCTTCCCAGGGAGAGGCTCACCACTGCCA       CAGCAGCATTGTCTTTTCCAAGTGCTGCTCCCATCACCTTCCCCAAAGCTGACATTGCTAGAGTCCCA               TCAGAAGAGTCTACAACTCTAGTCCAGAATCCACTATTACTACTTGAGAACAAACCCAGTGTAGAGAA       AACAACACCCACAATAAAATATTTCAGGACTGAAATTTCCCAAGTGACTCCAACTGGTGCAGTCATGA       CATATGCTCCAACATCCATACCCATGGAAAAAACTCACAAAGTAAACGCCAGTTACCCACGTGTGTCT       AGCACCAATGAAGCTAAAAGAGATTCAGTGATTACATCGTCACTTTCAGGTGCTATCACCAAGCCACC       AATGACTATTATAGCCAATTACAAGGTTTTCAAGAAGGAAATTCCCTGGCAACAGAACTTTGTAAATA       ACCATAACCCAAAAGGCAGATTAAGGAATCAACATAAAGTTAGTTTACAAAAAAGCACAGCTGTGATG       CTTCCTAAAACATCTCCTGCTTTACCACAGAGACAAAGTCTCCCCTCGCACCACACTACGACCAAAAC       ACACAATCCTGGAAGTCTTCCAACAAAGAAGGAGCTTCCCTTCCCACCCCTTAACCCTATGCTTCCTA       GTATTATAAGCAAAGACTCAAGTACAAAAAGCATCATATCAACGCAAACAGCAATACCAGCAACAACT       CCTACCTTCCCTGCATCTGTCATCACTTATGAAACCCAAACAGAGAGATCTAGAGCACAAACAATACA       AAGAGAACAGGAGCCTCAAAAGAAGAACAGGACTGACCCAAACATCTCTCCAGACCAGAGTTCTGGCT       TCACTACACCCACTGCTATGACACCTCCTGTTCTAACCACAGCCGAAACTTCAGTCAAGCCCAGTGTC       TCTGCATTCACTCATTCCCCACCAGAAAACACAACTGGGATTTCAAGCACAATCAGTTTTCATTCAAG       AACTCTTAATCTGACAGATGTGATTGAAGAACTAGCCCAAGCAAGTACTCAGACTTTGAAGAGCACAA       TTGCTTCTGAAACAACTTTGTCCAGCAAATCACACCAGAGTACCACAACTAGGAAAGCAATCATTAGA       CACTCAACCATACCACCATTCTTGAGCAGCAGTGCTACTCTAATGCCAGTTCCCATCTCCCCTCCCTT       TACTCAGAGAGCAGTTACTGACAACGTGGCGACTCCCATTTCCGGGCTTATGACAAATACAGTGGTCA       AGCTGCACGAATCCTCAAGGCACAATGCTAAACCACAGCAATTAGTAGCAGAGGTTGCAACATCCCCC       AAGGTTCACCCAAATGCCAAGTTCACAATTGGAACCACTCACTTCATCTACTCTAATCTGTTACATTC       TACTCCCATGCCAGCACTAACAACAGTTAAATCACAGAATTCTAAATTAACTCCATCTCCCTGGGCAG       AAAACCAATTTTGGCACAAACCATACTCAGAAATTGCTGAAAAAGGCAAAAAGCCAGAAGTAAGCATG       TTGGCTACTACAGGCCTGTCCGAGGCCACCACTCTTGTTTCAGATTGGGATGGACAGAAGAACACAAA       GAAGAGTGACTTTGATAAGAAACCAGTTCAAGAAGCAACAACTTCCAAACTCCTTCCCTTTGACTCTT       TGTCTAGGTATATATTTGAAAAGCCCAGGATAGTTGGAGGAAAAGCTGCAAGTTTTACTATTCCAGCT       AACTCAGATGCCTTTCTTCCCTGTGAAGCTGTTGGAAATCCCCTGCCCACCATTCATTGGACCAGAGT       CCCATCAGGTATGTCAGGACTTGATTTATCTAAGAGGAAACAGAATAGCAGGGTCCAGGTTCTCCCCA       ATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAAT       ACGTACCAAAGAGATCACAGTTCATTCCGGAAGCACTGTGGAACTGAAGTGCAGAGCAGAAGGTAGGC       CAAGCCCTACAGTTACCTGGATTCTTGCAAACCAAACAGTTGTCTCAGAATCATCCCAGGGAAGTAGG       CAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTATGACCGTGGCTTTTA       CAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAAATACAAGTCATTGCAGCAC       TGTACTGCAAAAGGAACTCCTCAGCCCAGCGTTTACTGGGTCCTCTCTGATGGCACTGAAGTGAAACC       ATTACAGTTTACCAATTCCAAGTTGTTCTTATTTTCAAATGGGACTTTGTATATAAGAAACCTAGCCT       CTTACAATGGAAGAGCGAGTGACCAGCCCCAGGATAGAAGCTGCATCCCAGAAAAGGACTGAAGTGAA       TTTTGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGTGGAGGT       TACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGGTGGGCAGCTGGATCCACGTCTACCCTAATGGA       TCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGTCTACTTGTGTGTGGCAAGAAACAAAAT       GGGGGATGATCTGATACTGATGCATGTTAGCCTAAGACTGAAACCTGCCAAAATTGACCACAAGCAGT       ATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTAGATTGCAAAGCTTCCGGCTCCCCAGTG       CCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAATGCAAGCCGATGACAGTGG       CCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTTTATACTTCAACAAAGTTGGGGTAGCGG       AGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGGAAAGATGAAATGAAGGTCCACTTAACA       GTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAACCAACAAGAGAATCAAAGCTGGAGACAC       AGCTGTCCTTGACTGTGAGGTCACTGGGGATCCCAAACCAAAAATATTTTGGTTGCTGCCTTCCAATG       ACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCCAATGGGTCTTTGACCATCAACAAAGTG       AAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGATGACACCAAAATGTA               CAAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTCTGTATACAAA   T   AGAACTGTTATTAAAG       CCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACACCATCTCCTGAAGTC       ATGTGGATCATGCCAGACAATATTTTCCTCACAGCCCCATACTATGGAAGCAGAATCACAGTCCATAA       AAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTATCTGTGTGGCCCGAA       ATGAAGGTGGAGAGAGCGTGTTGGTAGTACAGTTAGAAGTACTGGAAATGCTGAGAAGACCGACATTT       AGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATTGAATTGCTCTGTTGA       TGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATGGCACACGATTTTCCAATGGACCACAAA       GTTATCAGTATCTGATAGCAAGCAATGGTTCTTTTATCATTTCTAAAACAACTCGGGAGGATGCAGGA       AAATATCGCTGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCATATTAGAAATTGGCCA       GAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAGAATCTCTATCACTGC       ATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGTGGTTATGTAGTAGAC       AGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCATTAAAGAAGCAACAGC       TTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACACTGATTACTGTTCCAG       TAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATTGTCACCAGGACAGGG       GCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCACATGGGAGATGCCTGA       CCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGCTTCACTTACAAGGTA       CCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACAGCAAAGAACCCACTT       GGTAGTGATTATGCAGCAACGTATATTCAAGTAATC TGA   CATGAAATAATAAAGTC                                           NOV29ap, SNP13377641 of   SEQ ID NO:748   2617 aa   MW at 290200.2 kD           CG55776-01, Protein Sequence   SNP Pos: 2237       SNP Change: Asn to Asn                     MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNS           LVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVRLMVLKMSYNKVRKLQKDTFYGLRSLT       RLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSL       PQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPGIYIVLPDVIKCKKDRSPSSAQQCPLCMNP       RTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEAN       MVCSIQKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSET       PQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEM       RPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKS       GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGTP       DASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRP       LEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRF       RENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEE       FMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKN       INPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTN       KLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRR       FGRQRKIGGRGRIISPYRTPVLRPHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATA       ALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTY       APTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPWQQNFVNNH       NPKGRLRNQHKVSLQKSTAVMLPKTSPALPQRQSLPSHHTTTKTHNPGSLPTKKELPFPPLNPMLPSI       ISKDSSTKSIISTQTAIPATTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFT       TPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIA       SETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTNTVVKL       HESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAEN       QFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLS       YIFEKPRIVGGKAASFTIPAIASDAFLPCEAVGNPLPTIHWTRVPSGMSGLDLSKRKQNSRVQVLPNG       TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS       PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP       VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASS       DRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLP       SKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF       RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE       GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDM       ISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYT   N   RTVIKAT       AVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE       GGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSY       QYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHC       VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVM       IVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTL       VIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI                                     NOV29aq, SNP13377640   SEQ ID NO:749   7876 bP           of CG55776-01,   ORF Start: ATG at 6   ORF Stop: TGA at 7857       DNA Sequence   SNP Pos: 7218   SNP Change: T to C                       TCAGG   ATG AAGGTAAAAGGCAGAGGAATCACCTGCTTGCTGGTCTCCTTTGCTGTGATCTGCCTGGTC           GCCACCCCTGGGGGCAAGGCCTGTCCTCGCCGCTGTGCCTGTTATATGCCTACGGAGGTACACTGCAC       ATTTCGGTACCTGACTTCCATCCCAGACAGCATCCCGCCCAATGTGGAACGCATCAATTTAGGGTACA       ACAGCTTGGTTAGATTGATGGAAACAGATTTTTCTGGCCTGACCAAACTGGAGTTACTCATGCTTCAC       AGCAATGGCATTCACACAATCCCTGACAAGACCTTCTCAGATTTGCAGGCCTTGCAGGTGAGACTGAT       GGTCTTAAAAATGAGCTATAATAAAGTCCGAAAACTTCAGAAAGATACTTTTTATGGCCTCAGGAGCT       TGACACGATTGCACATGGACCACAACAATATTGAGTTTATAAACCCAGAGGTTTTTTATGGGCTCAAC       TTTCTCCGCCTGGTGCACTTGGAAGGAAATCAGCTCACTAAGCTCCACCCAGATACATTTGTCTCTTT       GAGCTACCTCCAGATATTTAAAATCTCTTTCATTAAGTTCCTATACTTGTCTGATAACTTCCTGACCT       CCCTCCCTCAAGAGATGGTCTCCTATATGCCTGACCTAGACAGCCTTTACCTGCATGGAAACCCATGG       ACCTGTGATTGCCATTTAAAGTGGTTGTCTGACTGGATACAGGAGAAGCCAGGTATCTATATTGTNTT       ACCAGATGTAATAAAATGCAAAAAAGATAGAAGTCCCTCTAGTGCTCAGCAGTGTCCACTTTGCATGA       ACCCTAGGACTTCTAAAGGCAAGCCGTTAGCTATGGTCTCAGCTGCAGCTTTCCAGTGTGCCAAGCCA       ACCATTGACTCATCCCTGAAATCAAAGAGCCTGACTATTCTGGAAGACAGTAGTTCTGCTTTCATCTC       TCCCCAAGGTTTCATGGCACCCTTTGGCTCCCTCACTTTGAATATGACAGATCAGTCTGGAAATGAAG       CTAACATGGTCTGCAGTATTCAAAAGCCCTCAAGGACATCACCCATTGCATTCACTGAAGAAAATGAC       TACATCGTGCTAAATACTTCATTTTCAACATTTTTGGTGTGCAACATAGATTACGGTCACATTCAGCC       AGTGTGGCAAATTTTGGCTTTGTACAGTGATTCTCCTCTGATACTAGAAAGGAGCCACTTGCTTAGTG       AAACACCGCAGCTCTATTACAAATATAAACAGGTGGCTCCTAAGCCTGAAGACATTTTTACCAACATA       GAGGCAGATCTCAGAGCAGATCCCTCTTGGTTAATGCAAGACCAAATTTCCTTGCAGCTGAACAGAAC       TGCCACCACATTCAGTACATTACAGATCCAGTACTCCAGTGATGCTCAAATCACTTTACCAAGAGCAG       AGATGAGGCCAGTGAAACACAAATGGACTATGATTTCAAGGGATAACAATACTAAGCTGGAACATACT       GCTTCTAGCTGATGGAAGTAAAGTGAGAGCCCCTTATGTCAGTGAGGATGGACGGATCCTAATAGACA       AAAGTGGAAAATTGGAACTCCAGATGGCTGATAGTTTTGACACAGGCGTATATCACTGTATAAGCAGC       AATTATGATGATGCAGATATTCTCACCTATAGGATAACTGTGGTAGAACCTTTGGTCGAAGCCTATCA       GGAAAATGGGATTCATCACACAGTTTTCATTGGTGAAACACTTGATCTTCCATGCCATTCTACTGGTA       TCCCAGATGCCTCTATTAGCTGGGTTATTCCAGGAAACAATGTGCTCTATCAGTCATCAAGAGACAAG       AAAGTTCTAAACAATGGCACATTAAGAATATTACAGGTCACCCCGAAAGACCAAGGTTATTATCGCTG       TGTGGCAGCCAACCCATCAGGGGTTGATTTTTTGATTTTCCAAGTTTCAGTCAAGATGAAAGGACAAA       AAGGAGCCACCAGGTGCACAACTCCGTACATCTGCTCTGATGGAGGCTGAGGTTGGAAAACACACCTC       AAGCACAAGTAAGAGGCACAACTATCGGGAATTAACACTCCAGCGACGTGGAGATTCAACACATCGAC       GTTTTAGGGAGAATAGGAGGCATTTCCCTCCCTCTGCTAGGAGAATTGACCCACAACATTGGGCGGCA       CTGTTGGAGAAAGCTAAAAAGAATGCTATGCCAGACAAGCGAGAAAATACCACAGTGAGCCCACCCCC       AGTGGTCACCCAACTCCCAAACATACCTGGTGAAGAAGACGATTCCTCAGGCATGCTCGCTCTACATG       AGGAATTTATGGTCCCGGCCACTAAAGCTTTGAACCTTCCAGCAAGGACAGTGACTGCTGACTCCAGA       ACAATATCTGATAGTCCTATGACAAACATAAATTATGGCACAGAATTCTCTCCTGTTGTGAATTCACA       AATACTACCACCTGAAGAACCCACAGATTTCAAACTGTCTACTGCTATTAAAACTACAGCCATGTCAA       AGAATATAAACCCAACCATGTCAAGCCAAATACAAGGCACAACCAATCAACATTCATCCACTGTCTTT       CCACTGCTACTTGGAGCAACTGAATTTCAGGACTCTGACCAGATGGGAAGAGGAAGAGAGCATTTCCA       AAGTAGACCCCCAATAACAGTAAGGACTATGATCAAAGATGTCAATGTCAAAATGCTTAGTAGCACCA       CCAACAAACTATTATTAGAGTCAGTAAATACCACAAATAGTCATCAGACATCTGTAAGAGAAGTGAGT       GAACCCAGGCACAATCACTTCTATTCTCACACTACTCAAATACTTAGCACCTCCACGTTCCCTTCAGA       TCCACACACAGCTGCTCATTCTCAGTTTCCGATCCCTAGAAATAGTACAGTTAACATCCCGCTGTTCA       GACGCTTTGGGAGGCAGAGGAAAATTGGCGGAAGGGGGCGGATTATCAGCCCATATAGAACTCCAGTT       CTGCGACGGCATAGATACAGCATTTTCAGGTCAACAACCAGAGGTTCTTCTGAAAAAAGCACTACTGC       ATTCTCAGCCACAGTGCTCAATGTGACATGTCTGTCCTGTCTTCCCAGGGAGAGGCTCACCACTGCCA       CAGCAGCATTGTCTTTTCCAAGTGCTGCTCCCATCACCTTCCCCAAAGCTGACATTGCTAGAGTCCCA               TCAGAAGAGTCTACAACTCTAGTCCAGAATCCACTATTACTACTTGAGAACAAACCCAGTGTAGAGAA       AACAACACCCACAATAAAATATTTCAGGACTGAAATTTCCCAAGTGACTCCAACTGGTGCAGTCATGA       CATATGCTCCAACATCCATACCCATGGAAAAAACTCACAAAGTAAACGCCACTTACCCACGTGTGTCT       AGCACCAATGAAGCTAAAAGAGATTCAGTGATTACATCGTCACTTTCAGGTGCTATCACCAAGCCACC       AATGACTATTATAGCCATTACAAGGTTTTCAAGAAGGAAAATTCCCTGGCAACAGAACTTTGTAAATA       ACCATAACCCAAAAGGCAGATTAAGGAATCAACATAAAGTTAGTTTACAAAAAAGCACAGCTGTGATG       ACACAATCCTGGAAGTCTTCCAACAAAGAAGGAGCTTCCCTTCCCACCCCTTAACCCTATGCTTCCTA       GTATTATAAGCAAAGACTCAAGTACAAAAAGCATCATATCAACGCAAACAGCAATACCAGCAACAACT       CCTACCTTCCCTGCATCTGTCATCACTTATGAAACCCAAACAGAGAGATCTAGAGCACAAACAATACA       AAGAGAACAGGAGCCTCAAAAGAAGAACAGGACTGACCCAAACATCTCTCCAGACCAGAGTTCTGGCT       TCACTACACCCACTGCTATGACACCTCCTGTTCTAACCACAGCCGAAACTTCAGTCAAGCCCAGTGTC       TCTGCATTCACTCATTCCCCACCAGAAAACACAACTGGGATTTCAAGCACAATCAGTTTTCATTCAAG       AACTCTTAATCTGACAGATGTGATTGAAGAACTAGCCCAAGCAAGTACTCAGACTTTGAAGAGCACAA       TTGCTTCTGAAACAACTTTGTCCAGCAAATCACACCAGAGTACCACAACTAGGAAAGCAATCATTAGA       CACTCAACCATACCACCATTCTTGAGCAGCAGTGCTACTCTAATGCCAGTTCCCATCTCCCCTCCCTT       TACTCAGAGAGCAGTTACTGACAACGTGGCGACTCCCATTTCCGGGCTTATGACAAATACAGTGGTCA       AGCTGCACGAATCCTCAAGGCACAATGCTAACCACAGCAATTAGTAGCAGAGGTTGCAAACATCCCCC       AAGGTTCACCCAAATGCCAAGTTCACAATTGGAACCACTCACTTCATCTACTCTAATCTGTTACATTC       TACTCCCATGCCAGCACTAACAACAGTTAAATCACAGAATTCTAAATTAACTCCATCTCCCTGGGCAG       AAAACCAATTTTGGCACAAACCATACTCAGAAATTGCTGAAAAAGGCAAAAAGCCAGAAGTAAGCATG       TTGGCTACTACAGGCCTGTCCGAGGCCACCACTCTTGTTTCAGATTGGGATGGACAGAAGAACACAAA       GAAGAGTGACTTTGATAAGAAACCAGTTCAAGAAGCAACAACTTCCAAACTCCTTCCCTTTGACTCTT       TGTCTAGGTATATATTTGAAAAGCCCAGGATAGTTGGAGGAAAAGCTGCAAGTTTTACTATTCCAGCT       AACTCAGATGCCTTTCTTCCCTGTGAAGCTGTTGGAAATCCCCTGCCCACCATTCATTGGACCAGAGT       CCCATCAGGTATGTCAGGACTTGATTTATCTAAGAGGAAACAGAATAGCAGGGTCCAGGTTCTCCCCA       ATGGTACCCTGTCCATCCAGAGGGTGGAAATTCAGGACCGCGGACAGTACTTGTGTTCCGCATCCAAT       CTGTTTGGCACAGACCACCTTCATGTCACCTTGTCTGTGGTTTCCTATCCTCCCAGGATCCTGGAGAG       ACGTACCAAAGAGATCACAGTTCATTCCGGAAGCACTGTGGAACTGAAGTGCAGAGCAGAAGGTAGGC       CAAGCCCTACAGTTACCTGGATTCTTGCAAACCAAACAGTTGTCTCAGAATCATCCCAGGGAAGTAGG       CAGGCTGTGGTGACGGTTGACGGAACATTGGTCCTCCACAATCTCAGTATTTATGACCGTGGCTTTTA       CAAATGTGTGGCCAGCAACCCAGGTGGCCAGGATTCACTGCTGGTTAAAATACAAGTCATTGCAGCAC       CACCTGTTATTCTAGAGCAAAGGAGGCAAGTCATTGTAGGCACTTGGGGTGAAAGTTTAAAACTGCCC       TGTACTGCAAAAGGAACTCCTCAGCCCAGCGTTTACTGGGTCCTCTCTGATGGCACTGAAGTGAAACC       ATTACAGTTTACCAATTCCAAGTTGTTCTTATTTTCAAATGGGACTTTGTATATAAGAAACCTAGCCT       CTTCAGACAGGGGCACTTATGAATGCATTGCTACCAGTTCCACTGGTTCGGAGCGAAGAGTAGTAATG       CTTACAATGGAAGAGCGAGTGACCAGCCCCAGGATAGAAGCTGCATCCCAGAAAAGGACTGAAGTGAA       TTTTGGGGACAAATTACTACTGAACTGCTCAGCCACTGGGGAGCCCAAACCCCAAATAATGTGGAGGT       TACCATCCAAGGCTGTGGTCGACCAGCAGCATAGGGTGGGCAGCTGGATCCACGTCTACCCTAATGGA       TCCCTGTTTATTGGATCAGTAACAGAAAAAGACAGTGGTGTCTACTTGTGTGTGGCAAGAAACAAAAT       GGGGGATGATCTGATACTGATGCATGTTAGCCTAAGACTGAAACCTGCCAAAATTGACCACAAGCAGT       ATTTTAGAAAGCAAGTGCTCCATGGGAAAGATTTCCAAGTAGATTGCAAAGCTTCCGGCTCCCCAGTG       CCAGAGATATCTTGGAGTTTGCCTGATGGAACCATGATCAACAATGCAATGCAAGCCGATGACAGTGG       CCACAGGACTAGGAGATATACCCTTTTCAACAATGGAACTTTATACTTCAACAAAGTTGGGGTAGCGG       AGGAAGGAGATTATACTTGCTATGCCCAGAACACCCTAGGGAAAGATGAAATGAAGGTCCACTTAACA       GTTATAACAGCTGCTCCCCGGATAAGGCAGAGTAACAAAACCAACAAGAGAATCAAAGCTGGAGACAC       ACATGATTTCCTTCTCCATTGATAGGTACACATTTCATGCCAATGGGTCTTTGACCATCAACAAAGTG       AAACTGCTCGATTCTGGAGAGTACGTATGTGTAGCCCGAAATCCCAGTGGGGATGACACCAAAATGTA               CAAACTGGATGTGGTCTCTAAACCTCCATTAATCAATGGTCTGTATACAAACAGAACTGTTATTAAAG       CCACAGCTGTGAGACATTCCAAAAAACACTTTGACTGCAGAGCTGAAGGGACACCATCTCCTGAAGTC       AAATGGAACCTTGGAAATTAGGAATGTGAGGCTTTCAGATTCAGCCGACTTTATCTGTGTGGCCCGAA       AGAAATCCATTTAATGAAAAAATAGTTGCCCAGCTGGGAAAGTCCACAGCATTGAATTGCTCTGTTGA       TGGTAACCCACCACCTGAAATAATCTGGATTTTACCAAATGGCACACGATTTTCCAATGGACCACAAA       AAATATCGCCGTGCAGCTAGGAATAAAGTTGGCTATATTGAGAAATTAGTCATATTAGAAATTGGCCA       GAAGCCAGTTATTCTTACCTATGCACCAGGGACAGTAAAAGGCATCAGTGGAGAATCTCTATCACTGC       ATTGTGTGTCTGATGGAATCCCTAAGCCAAATATCAAATGGACTATGCCAAGTGGTTATGTAGTAGAC       AGGCCTCAAATTAATGGGAAATACATATTGCATGACAATGGCACCTTAGTCATTAAAGAAGCAACAGC       TTATGACAGAGGAAACTATATCTGTAAGGCTCAAAATAGTGTTGGTCATACACTGATTACTGTTCCAG       TAATGATTGTAGCCTACCCTCCCCGAATTACAAATCGTCCACCCAGGAGTATTGTCACCAGGACAGGG       GCAGCCTTTCAGCTCCACTGTGTGGCCTTGGGAGTTCCCAAGCCAGAAATCACATGGGAGATGCCTGA       CCACTCCCTTCTCTCAACGGCAAGTAAAGAGAGGACACATGGAAGTGAGCAGCTTCACTTACAAGGTA       CCCTAGTCATTCAGAATCCCCAAACCTCCGATTCTGGGATATACAAATGCACAGCAAAGAACCCACTT       GGTAGTGATTATGCAGCAACGTATATTCAAGTAATC TGA   CATGAAATAATAAAGTC                                           NOV29aq, SNP13377640 of   SEQ ID NO:750   2617 aa   MW at 290253.2 kD           CG55776-01, Protein Sequence   SNP Pos: 2405       SNP Change: Cys to Arg                     MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNS           LVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVRLMVLKMSYNKVRKLQKDTFYGLRSLT       RLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSL       PQEMKTSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPGIYIVLPDVIKCKKDRSPSSAQQCPLCAP       RTSKGKPLAMVSAAAFQCAKPTIDSSLKSKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEAN       MVCSIQKPSRTSPIAFTEENDYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSET       PQLYYKYKQVAPKPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPEAEM       RPVKHKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPNVDWLLADGSKVRAPYVSEDGRILIDKS       GKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIP       DASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRP       LEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRF       RENRRHFPPSARRIDPQHWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEE       FMVPATKALNLPARTVTADSRTISDSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKN       INPTMSSQIQGTTNQHSSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTN       KLLLESVNTTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRR       FGRQRKIGGRGRIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPRERLTTATA       ALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYFRTEISQVTPTGAVMTY       APTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPPMTIIAITRFSRRKIPWQQNFVNNH       NPKGRLRNQHKVSLQKSTAVMLPKTSPALPQRQSLPSHHTTTKTHNPGSLPTKKELPFPPLNPMLPSI       ISKDSSTKSIISTQTAIPATTPTFPASVITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFT       TPTAMTPPVLTTAETSVKPSVSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIA       SETTLSSKSHQSTTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTNTVVKL       HESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSPWAEN       QFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLS       RYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGMSGLDLSKRKQNSRVQVLPNG       TLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPS       PTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPP       VILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASS       DRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLP       SKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF       RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE       GDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDM       ISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKAT       AVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE       QYLIASNGSFIISKTTREDAGKYPRAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHC       VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVM       IVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTL       VIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 29B.  
               TABLE 29B                       Comparison of the NOV29 protein sequences.                                            NOV29a   MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVE                   NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVE               NOV29aa   MKVKGRGITCLLVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVE               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   RINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVRLMVLKMSYNK               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   RINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVRLMVLKMSYNK               NOV29aa   RINLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVRLMVLKMSYNK               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   VRKLQKDTFYGLRSLTRLHNDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSL               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   VRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSL               NOV29aa   VRKLQKDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSL               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   SYLQIFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQE               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   SYLQIFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQE               NOV29aa   SYLQIFKISFIKFLYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQE               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   KPGIYIVLPDVIKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAAFQCAKPTIDSSLK               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   KPGIYIVLPDVIKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAAFQCAKPTIDSSLK               NOV29aa   KPGIYIVLPDVIKCKKDRSPSSAQQCPLCMNPRTSKGKPLAMVSAAAFQCAKPTIDSSLK               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   SKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEANMVCSIQKPSRTSPIAFTEEN               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   SKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEANMVCSIQKPSRTSPIAFTEEN               NOV29aa   SKSLTILEDSSSAFISPQGFMAPFGSLTLNMTDQSGNEANMVCSIQKPSRTSPIAFTEEN               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   DYIVLNTSFSTFLVCNIDYGHIQPVWQILALYSDSPLILERSHLLSETPQLYYKYKQVAP               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   DYIVLNTSFSTFLVCNIDYGHTQPVWQILALYSDSPLILERSHLLSETPQLYYKYKQVAP               NOV29aa   DYIVLNTSFSTFLVCNIDYGHTQPVWQILALYSDSPLILERSHLLSETPQLYYKYKQVAP               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   KPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAEMRPVK               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   KPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPPAENRPVK               NOV29aa   KPEDIFTNIEADLRADPSWLMQDQISLQLNRTATTFSTLQIQYSSDAQITLPEAENRPVK               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   HKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRIL               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   HKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRIL               NOV29aa   HKWTMISRDNNTKLEHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRIL               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   IDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGE               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   IDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGE               NOV29aa   IDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGE               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   TLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAAN               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   TLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAAN               NOV29aa   TLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAAN               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   PSGVDFLIFQVSVKMKGQRPLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVG               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   PSGVDFLIFQVSVKMKGQRPLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVG               NOV29aa   PSGVDFLIFQVSVKMKGQRPLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAEVG               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   KHTSSTSKRHNYRELTLQRRGDSTHRRFRENRRHFPPSARRIDPQHWAALLEKAKKNAMP               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   KHTSSTSKRHNYRELTLQRRGDSTHRRFRENRRHFPPSARRIDPQHWAALLEKAKKNAMP               NOV29aa   KHTSSTSKRHNYRELTLQRRGDSTHRRFRENRRHFPPSARRIDPQHWAALLEKAKKNAMP               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   DKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEEFMVPATKALNLPARTVTADSRTIS               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   DKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEEFMVPATKALNLPARTVTADSRTIS               NOV29aa   DKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALHEEFMVPATKALNLPARTVTADSRTIS               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   DSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKNINPTMSSQIQGTTNQH               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   DSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKNINPTMSSQIQGTTNQH               NOV29aa   DSPMTNINYGTEFSPVVNSQILPPEEPTDFKLSTAIKTTAMSKNINPTMSSQIQGTTNQH               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   SSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKMLSSTTNKLLLESVN               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   SSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKNLSSTTNKLLLESVN               NOV29aa   SSTVFPLLLGATEFQDSDQMGRGREHFQSRPPITVRTMIKDVNVKNLSSTTNKLLLESVN               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   TTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRR               NOV29b   ------------------------------------------------------------               KOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   TTNSHQTSVREVSEPRHNHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRR               NOV29aa   TTNSHQTSVREVSEPRENHFYSHTTQILSTSTFPSDPHTAAHSQFPIPRNSTVNIPLFRR               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   FGRQRKIGGRGRIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPR               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   FGRQRKIGGRGRIISPYRTPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPR               NOV29aa   FGRQRKIGGRGRIISPYRYPVLRRHRYSIFRSTTRGSSEKSTTAFSATVLNVTCLSCLPR               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   ERLTTATAALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYF               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   ERLTTATAALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYF               NOV29aa   ERLTTATAALSFPSAAPITFPKADIARVPSEESTTLVQNPLLLLENKPSVEKTTPTIKYF               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   RTEISQVTPTGAVMTYAPTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPP               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   RTEISQVTPTGAVMTYAPTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPP               NOV29aa   RTEISQVTPTGAVMTYAPTSIPMEKTHKVNASYPRVSSTNEAKRDSVITSSLSGAITKPP               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   MTIIAITRFSRRKIPWQQNFVNNHNPKGRLRNQHKVSLQKSTAVMLPKTSPALPQRQSLP               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   MTIIAITRFSRRKIPWQQNFVNNHNPKGRLRNQHKVSLQKSTAVMLPKTSPALPQRQSLP               NOV29aa   MTIIAITRFSRRKIPWQQNFVNNHNPKGRLRNQHKVSLQKSTAVMLPKTSPALPQRQSLP               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   SHHTTTKTHNPGSLPTKKELPFPPLNPMLPSIISKDSSTKSIISTQTAIPATTPTFPASV               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   SHHTTTKTHNPGSLPTKKELPFPPLNPMLPSIISKDSSTKSIISTQTAIPATTPTFPASV               NOV29aa   SHHTTTKTHNPGSLPTKKELPFPPLNPMLPSIISKDSSTKSIISTQTAIPATTPTFPASV               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   ITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFTTPTAMTPPVLTTAETSVKPS               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   ITYETQTERSEAQTIQREQEPQKKNRTDPNISPDQSSGFTTPTAMTPPVLTTAETSVKPS               NOV29aa   ITYETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGFTTPTAMTPPVLTTAETSVKPS               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   VSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIASETTLSSKSHQS               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   VSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIASETTLSSKSHQS               NOV29aa   VSAFTHSPPENTTGISSTISFHSRTLNLTDVIEELAQASTQTLKSTIASETTLSSKSHQS               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   TTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQPAVTDNVATPISGLMTNTVVKLHESS               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   TTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTNTVVKLHESS               NOV29aa   TTTRKAIIRHSTIPPFLSSSATLMPVPISPPFTQRAVTDNVATPISGLMTNTVVKLHESS               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   RHNAKPQQLVAEVATSFKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSP               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   RHNAKPQQLVAEVATSPKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSP               NOV29aa   RHNAKPQQLVAEVATSFKVHPNAKFTIGTTHFIYSNLLHSTPMPALTTVKSQNSKLTPSP               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   WAENQFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEA               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------------------------------------               NOV29y   ------------------------------------------------------------               NOV29z   WAENQFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEA               NOV29aa   WAENQFWHKPYSEIAEKGKKPEVSMLATTGLSEATTLVSDWDGQKNTKKSDFDKKPVQEA               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ------------------------------------------------------------               NOV29af   ------------------------------------------------------------               NOV29ag   ------------------------------------------------------------               NOV29a   TTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGM               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ------------------------------TLENSDAFLPCEAVGNPLPTIHWTRVPS--               NOV29y   ------------------------------TRSNSDAFLPCEAVGNPLPTIHWTRVPS--               NOV29z   TTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGM               NOV29aa   TTSKLLPFDSLSRYIFEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGM               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ---------------------------------NSDAFLPCEAVGNPLPTIHWTRVPS--               NOV29af   ---------------------------------NSDAFLPCEAVGNPLPTIHWTRVPS--               NOV29ag   ------------------------------------------------------------               NOV29a   SGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPR               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   -GLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPR               NOV29y   -GLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPR               NOV29z   SGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPR               NOV29aa   SGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPR               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   -GLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPR               NOV29af   -GLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPR               NOV29ag   ------------------------------------------------------------               NOV29a   ILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLV               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   ILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLV               NOV29y   ILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLV               NOV29z   ILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLV               NOV29aa   ILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLV               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   ILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLV               NOV29af   ILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLV               NOV29ag   ------------------------------------------------------------               NOV29a   LHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTA               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   LHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTA               NOV29y   LHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTA               NOV29z   LHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTA               NOV29aa   LHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQPRQVIVGTWGESLKLPCTA               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   LHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTA               NOV29af   LHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTA               NOV29ag   ------------------------------------------------------------               NOV29a   KGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSE               NOV29b   ------------------------------------------------------------               NOV29c   ------------------------------------------------------------               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   ------------------------------------------------------------               NOV29i   ------------------------------------------------------------               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   ------------------------------------------------------------               NOV29x   KGTPQPSVYWVLSDGTEVKFLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSE               NOV29y   KGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSE               NOV29z   KGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSE               NOV29aa   KGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSE               NOV29ab   ------------------------------------------------------------               NOV29ac   ------------------------------------------------------------               NOV29ad   ------------------------------------------------------------               NOV29ae   KGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSE               NOV29af   KGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSE               NOV29ag   ------------------------------------------------------------               NOV29a   RRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQ               NOV29b   ------------------------------------------------------------               NOV29c   -------------------GSAAAPFTLEGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQ               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   -------------------GSAAAPFTLEGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQ               NOV29i   -------------------GSAAAPFTLEGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQ               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   -------------------GSAAAPFTLEGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQ               NOV29x   RRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQ               NOV29y   RRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQTMWRLPSKAVVDQQ               NOV29z   RRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQTMWRLPSKAVVDQQ               NOV29aa   RRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQTMWRLPSKAVVDQQ               NOV29ab   ------------------------------------------------------------               NOV29ac   -----------------------------GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQ               NOV29ad   -----------------------------GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQ               NOV29ae   RRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQ               NOV29af   RRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQ               NOV29ag   ------------------------------------------------------------               NOV29a   HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF               NOV29b   ------------------------------------------------------------               NOV29c   HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF               NOV29i   HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF               NOV29x   HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF               NOV29y   HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF               NOV29z   HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF               NOV29aa   HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLELKPAKIDHKQYF               NOV29ab   ------------------------------------------------------------               NOV29ac   HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF               NOV29ad   HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF               NOV29ae   HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF               NOV29af   HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYF               NOV29ag   ------------------------------------------------------------               NOV29a   RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF               NOV29b   ------------------------------------------------------------               NOV29c   RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF               NOV29i   RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF               NOV29j   ------------------------------------------------------------               NOV29k   ------------------------------------------------------------               NOV29l   ------------------------------------------------------------               NOV29m   ------------------------------------------------------------               NOV29n   ------------------------------------------------------------               NOV29o   ------------------------------------------------------------               NOV29p   ------------------------------------------------------------               NOV29q   ------------------------------------------------------------               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF               NOV29x   RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF               NOV29y   RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF               NOV29z   RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF               NOV29aa   RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF               NOV29ab   ------------------------------------------------------------               NOV29ac   RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF               NOV29ad   RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF               NOV29ae   RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF               NOV29af   RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF               NOV29ag   ------------------------------------------------------------               NOV29a   NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT               NOV29b   ------------------------------------------------------------               NOV29c   NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT               NOV29i   NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT               NOV29j   ----------------------------------------------TLEGDKLLLNCSAT               NOV29k   ----------------------------------------------TLEGDKLLLNCSAT               NOV29l   ----------------------------------------------TLEGDKLLLNCSAT               NOV29m   ----------------------------------------------TLEGDKLLLNCSAT               NOV29n   ----------------------------------------------TLEGDKLLLNCSAT               NOV29o   ----------------------------------------------TLEGDKLLLNCSAT               NOV29p   ----------------------------------------------TLEGDKLLLNCSAT               NOV29q   ----------------------------------------------TLEGDKLLLNCSAT               NOV29r   -------------------------------------------------------APRPP               NOV29s   ----------------------------------------------TLEMKVKGRGITCL               NOV29t   ----------------------------------------------TLEMKVKGRGITCL               NOV29u   ----------------------------------------------TLEMKVKGRGITCL               NOV29v   ----------------------------------------------TLEMKVKGRGITCL               NOV29w   NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT               NOV29x   NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT               NOV29y   NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT               NOV29z   NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDREVT               NOV29aa   NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT               NOV29ab   ------------------------------------------------------------               NOV29ac   NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT               NOV29ad   NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT               NOV29ae   NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT               NOV29af   NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVT               NOV29ag   ------------------------------------------------------------               NOV29a   GDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29b   -------------------------------------------TLENVERINLGYNSLVR               NOV29c   GDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29d   --------------KLACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVR               NOV29e   --------------KLACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVR               NOV29f   --------------KLACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVR               NOV29g   --------------KLACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVR               NOV29h   GDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29i   GDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29j   GEPKPQIMWRLPS-KAVVDQQHRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29k   GEPKPQIMWRLPS-KAVVDQQHRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29l   GEPKPQIMWRLPS-KAVVDQQHRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29m   GEPKPQIMWRLPS-KAVVDQQHRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29n   GEPKPQIMWRLPS-KAVVDQQHRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29o   GEPKPQIMWRLPS-KAVVDQQHRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29p   GEPKPQIMWRLQS-KAVVDQQHRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29q   GEPKHQIMWRLPS-KAVVDQQHRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29r   PSPSSVLAAVPVICTLECPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVR               NOV29s   LVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVR               NOV29t   LVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVR               NOV29u   LVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVR               NOV29v   LVSFAVICLVATPGGKACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVR               NOV29w   GDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29x   GDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29y   GDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29z   GDPKPKIFWLLPS---------------NGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29aa   --------------------------HANGSLTINKVKLLDSGEYVCVARNPSGDDTKMY               NOV29ab   ----------------ACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVR               NOV29ac   GDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKIY               NOV29ad   GDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKIY               NOV29ae   GDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKIY               NOV29af   GDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKIY               NOV29ag   ----------------ACPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLVR               NOV29a   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCPAEGTPSPEVMWIMPDNIFLTAPYY               NOV29b   LMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSL               NOV29c   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29d   LMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSL               NOV29e   LMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSL               NOV29f   LMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSL               NOV29g   LMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSL               NOV29h   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29i   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29j   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29k   KLDVVSKPPLINGLYThRTVIKATAVRHSKKHFDCPAEGTPSPEVMWIMPDNIFLTAPYY               NOV29l   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29m   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29n   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29o   KLDVVSKPPLINGLYTNRTVIKATAMRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29p   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29q   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29r   LMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSL               NOV29s   LMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSL               NOV29t   LMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSL               NOV29u   LMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSL               NOV29v   LMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSL               NOV29w   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29x   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29y   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29z   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29aa   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29ab   LMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSL               NOV29ac   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29ad   KLDVVSKPPLINGLYThRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29ae   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY               NOV29af   KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCPAEGTPSPEVMWIMPDNIFLTAPYY               NOV29ag   LMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSL               NOV29a   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29b   TRLHMDHNN--IEFINPEVFDGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKF               NOV29c   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29d   TRLHMDHNN--IEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKF               NOV29e   TRLHMDHNN--IEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKF               NOV29f   TRLHMDHNN--IEFINPEVFDGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKF               NOV29g   TRLHMDHNN--IEFINPEVFDGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKF               NOV29h   GSRITVHKNGTLEIRNRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29i   GSRITVHKNGTLEIRNRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29j   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29k   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29l   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29m   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29n   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29o   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29p   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPAFRNPFNEK               NOV29q   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29r   TRLHMDHNN--IEFINPEVFDGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKF               NOV29s   TRLHMDHNN--IEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKF               NOV29t   TRLHMDHNN--IEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKF               NOV29u   TRLHMDHNN--IEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKF               NOV29v   TRLHMDHNN--IEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKF               NOV29w   GSRITVHKNGTLEIRYVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29x   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29y   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29z   GGRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29aa   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29ab   TRLHMDHNN--IEFINPEVFDGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKF               NOV29ac   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29ad   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29ae   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29af   GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFNEK               NOV29ag   TRLHMDHNN--IEFINPEVFDGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKF               NOV29a   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29b   LYLSDNFLTSLPQEMVSYMP------LEG-------------------------------               NOV29c   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29d   LYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSP               NOV29e   LYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSP               NOV29f   LYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSP               NOV29g   LYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLFDWIQEKPDVIKCKKDRSP               NOV29h   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29i   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29j   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29k   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29l   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29m   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29n   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29o   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29p   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29q   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29r   LYLSDNFLTSLPQEMVSYMP------LEGKGGRA--------------------------               NOV29s   LYLSDNFLTSLPQEMVSYMP------LEG-------------------------------               NOV29t   LYLSDNFLTSLPQEMVSYMP------LEG-------------------------------               NOV29u   LYLSDNFLTSLPQEMVSYMP------LEG-------------------------------               NOV29v   LYLSDNFLTSLPQEMVSYMP------LEG-------------------------------               NOV29w   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29x   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29y   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29z   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29aa   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29ab   LYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSP               NOV29ac   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29ad   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29ae   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29af   IVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDA               NOV29ag   LYLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSP               NOV29a   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29b   ------------------------------------------------------------               NOV29c   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29d   SSAQQCPLCMNPRTSKGKPLAMVSAAAFQCALE---------------------------               NOV29e   SSAQQCPLCMNPRTSKGKPLAMVSAAAFQCALE---------------------------               NOV29f   SSAPQCPLCNNPRTSKGKPLAMVSAAAFQCALE---------------------------               NOV29g   SSAQQCPLCMNPRTSKGKPLAMVSAAAFQCALE---------------------------               NOV29h   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29i   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29j   GKNRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29k   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29l   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29m   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29n   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29o   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29p   GKYRCAAPNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29q   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29x   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29y   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29z   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29aa   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29ab   SSAQQCPLCMNPRTSKGKPLAMVSAAAFQCA-----------------------------               NOV29ac   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29ad   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29ae   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29af   GKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW               NOV29ag   SSAQQCPLCMNPRTSKGKPLAMVSAAAFQCA-----------------------------               NOV29a   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29b   ------------------------------------------------------------               NOV29c   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29i   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29j   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29k   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29l   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29m   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29n   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29o   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29p   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29q   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29x   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29y   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29z   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29aa   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29ab   ------------------------------------------------------------               NOV29ac   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29ad   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29ae   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29af   TMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAY               NOV29ag   ------------------------------------------------------------               NOV29a   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29b   ------------------------------------------------------------               NOV29c   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29d   ------------------------------------------------------------               NOV29e   ------------------------------------------------------------               NOV29f   ------------------------------------------------------------               NOV29g   ------------------------------------------------------------               NOV29h   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29i   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29j   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29k   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHRSEQLHL               NOV29l   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29m   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29n   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29o   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29p   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29q   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMSDHSLLSTASKERTHGSEQLHL               NOV29r   ------------------------------------------------------------               NOV29s   ------------------------------------------------------------               NOV29t   ------------------------------------------------------------               NOV29u   ------------------------------------------------------------               NOV29v   ------------------------------------------------------------               NOV29w   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29x   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29y   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29z   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29aa   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29ab   ------------------------------------------------------------               NOV29ac   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29ad   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29ae   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29af   PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL               NOV29ag   ------------------------------------------------------------               NOV29a   QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI--------               NOV29b   ---------------------------------------------               NOV29c   QGTLVIQNPQTSDSGIYKCTALE----------------GKGGRA               NOV29d   ---------------------------------------------               NOV29e   ---------------------------------------------               NOV29f   ---------------------------------------------               NOV29g   ---------------------------------------------               NOV29h   QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVILEGKGGRA               NOV29i   QGTLVIQNPQTSDSGIYKCTALE----------------GKGGRA               NOV29j   QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVILEG-----               NOV29k   QGTLVIQNPQTSDSGIYKCTALEG---------------------               NOV29l   QGTLVIQNPQTSDSGIYKCTALEGKGE------------------               NOV29m   QGTLVIQNPQTSDSGIYKCTALEG---------------------               NOV29n   QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVILEG-----               NOV29o   QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVILEG-----               NOV29p   QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVILEG-----               NOV29q   QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVILEG-----               NOV29r   ---------------------------------------------               NOV29s   ---------------------------------------------               NOV29t   ---------------------------------------------               NOV29u   ---------------------------------------------               NOV29v   ---------------------------------------------               NOV29w   QGTLVIQNPQTSDSGIYKCTALE----------------GKGGRA               NOV29x   QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVILEG-----               NOV29y   QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVILEG-----               NOV29z   QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI--------               NOV29aa   QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI--------               NOV29ab   ---------------------------------------------               NOV29ac   QGTLVIQNPQTSDSGIYKCTA------------------------               NOV29ad   QGTLVIQNPQTSDSGIYKCTA------------------------               NOV29ae   QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI--------               NOV29af   QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI--------               NOV29ag   ---------------------------------------------               NOV29a   (SEQ ID NO: 666)               NOV29b   (SEQ ID NO: 668)               NOV29c   (SEQ ID NO: 670)               NOV29d   (SEQ ID NO: 672)               NOV29e   (SEQ ID NO: 674)               NOV29f   (SEQ ID NO: 676)               NOV29g   (SEQ ID NO: 678)               NOV29h   (SEQ ID NO: 680)               NOV29i   (SEQ ID NO: 682)               NOV29j   (SEQ ID NO: 684)               NOV29k   (SEQ ID NO: 686)               NOV29l   (SEQ ID NO: 688)               NOV29m   (SEQ ID NO: 690)               NOV29n   (SEQ ID NO: 692)               NOV29o   (SEQ ID NO: 694)               NOV29p   (SEQ ID NO: 696)               NOV29q   (SEQ ID NO: 698)               NOV29r   (SEQ ID NO: 700)               NOV29s   (SEQ ID NO: 702)               NOV29t   (SEQ ID NO: 704)               NOV29u   (SEQ ID NO: 706)               NOV29v   (SEQ ID NO: 708)               NOV29w   (SEQ ID NO: 710)               NOV29x   (SEQ ID NO: 712)               NOV29y   (SEQ ID NO: 714)               NOV29z   (SEQ ID NO: 716)               NOV29aa   (SEQ ID NO: 718)               NOV29ab   (SEQ ID NO: 720)               NOV29ac   (SEQ ID NO: 722)               NOV29ad   (SEQ ID NO: 724)               NOV29ae   (SEQ ID NO: 726)               NOV29af   (SEQ ID NO: 728)               NOV29ag   (SEQ ID NO: 730)                  
 
      Further analysis of the NOV29a protein yielded the following properties shown in Table 29C.  
               TABLE 29C                       Protein Sequence Properties NOV29a                                        SignalP analysis:   Cleavage site between residues 29 and 30       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 6; pos. chg 3; neg. chg 0           H-region:   length 20; peak value 10.48           PSG score:   6.08                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −1.23           possible cleavage site: between 28 and 29                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 28)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 29           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 0                             PERIPHERAL   Likelihood = 1.91 (at 1062)                         ALOM score: 0.37 (number of TMSs: 0)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 14           Charge difference: −2.0 C(2.0)-N(4.0)           N &gt;= C: N-terminal side will be inside       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   3   Hyd Moment(75):   5.15           Hyd Moment(95):   8.32   G content:   4           D/E content:   1   S/T content:   4                         Score: −2.83       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 56 FRY|LT                 NUCDISC: discrimination of nuclear localization signals                         pat4: RRHR (3) at 1043           pat7: PVLRRHR (3) at 1040           pat7: PQKKNRT (4) at 1341           bipartite: RRIDPQHWAALLEKAKK at 760           content of basic residues: 11.1%           NLS Score: 0.81       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: found                         ILPN at 2366                 RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         73.9%: nuclear            8.7%: mitochondrial            8.7%: extracellular, including cell wall            4.3%: cytoplasmic            4.3%: vacuolar                 &gt;&gt; prediction for CG55776-01 is nuc (k = 23)                  
 
      A search of the NOV29a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 29D.  
               TABLE 29D                          Geneseq Results for NOV29a                                         NOV29a   Identities/                   Residues/   Similarities       Geneseq   Protein/Organism/Length   Match   for the   Expect       Identifier   [Patent #, Date]   Residues   Matched Region   Value               ABG31323   Human OCP protein -  Homo sapiens ,   1 . . . 2617   2535/2637 (96%)   0.0           2589 aa. [WO200246364-A2,   1 . . . 2589   2541/2637 (96%)           13-JUN-2002]       AAB47935   Human OCP -  Homo sapiens ,   1 . . . 2617   2534/2637 (96%)   0.0           2587 aa. [US2002022026-A1,   1 . . . 2587   2540/2637 (96%)           21-FEB-2002]       ABG32896   Human osteoclast protein (OCP) #2 -   1 . . . 2617   2534/2637 (96%)   0.0             Homo sapiens , 2587 aa.   1 . . . 2587   2540/2637 (96%)           [US2002086825-A1, 04-JUL-2002]       ABG32891   Human osteoclast protein (OCP) #1 -   1 . . . 2616   2533/2636 (96%)   0.0             Homo sapiens , 2586 aa.   1 . . . 2586   2539/2636 (96%)           [US2002086825-A1, 04-JUL-2002]       ABG31317   Human 5 + 3 corrected OCP protein -   1 . . . 2616   2526/2636 (95%)   0.0             Homo sapiens , 2586 aa.   1 . . . 2586   2534/2636 (95%)           [WO200246364-A2, 13-JUN-2002]                  
 
      In a BLAST search of public sequence databases, the NOV29a protein was found to have homology to the proteins shown in the BLASTP data in Table 29E.  
               TABLE 29E                          Public BLASTP Results for NOV29a                                         NOV29a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             Q8NA84   Hypothetical protein FLJ35750 -  Homo     1982 . . . 2617   636/636   (100%)   0.0             sapiens  (Human), 650 aa.    15 . . . 650   636/636   (100%)       AAH31063   Similar to hypothetical protein   2016 . . . 2617   601/602   (99%)   0.0           9030224D03 -  Homo sapiens  (Human),    1 . . . 602   602/602   (99%)           602 aa.       Q9NR99   Adlican -  Homo sapiens  (Human), 2828   1637 . . . 2616   451/980   (46%)   0.0           aa.   1851 . . . 2827   640/980   (65%)       BAC28314   Adult male colon cDNA, RIKEN full-length   2079 . . . 2617   419/539   (77%)   0.0           enriched library, clone: 9030224D03    1 . . . 539   479/539   (88%)           product: hypothetical Immunoglobulin and           major histocompatibility complex           domain/Immunoglobulin C-2           type/Immunoglobulin-like/Immunoglobulin           subtype containing protein, full insert           sequence -  Mus musculus  (Mouse), 539           aa (fragment).       Q8N772   Hypothetical protein FLJ25972 -  Homo     2219 . . . 2617   399/399   (100%)   0.0             sapiens  (Human), 399 aa.    1 . . . 399   399/399   (100%)                  
 
      PFam analysis predicts that the NOV29a protein contains the domains shown in the Table 29F.  
               TABLE 29F                          Domain Analysis of NOV29a                                             Identities/                       Similarities           Pfam   NOV29a   for the   Expect           Domain   Match Region   Matched Region   Value                                                 LRRNT   28 . . . 56   12/35 (34%)   0.00015                   23/35 (66%)           LRR    82 . . . 105    8/25 (32%)   0.25                   19/25 (76%)           LRR   134 . . . 157    8/25 (32%)   0.088                   21/25 (84%)           LRR   158 . . . 181   12/25 (48%)   0.32                   19/25 (76%)           LRRCT   223 . . . 291   17/69 (25%)     8e−10                   52/69 (75%)           ig   501 . . . 564   16/67 (24%)   0.59                   40/67 (60%)           ig   599 . . . 658   18/63 (29%)   1.9e−07                   44/63 (70%)           ig   1654 . . . 1719   14/69 (20%)   0.002                   46/69 (67%)           ig   1754 . . . 1816   17/66 (26%)   5.7e−05                   45/66 (68%)           ig   1851 . . . 1913   19/66 (29%)     1e−07                   47/66 (71%)           ig   1950 . . . 2012   21/66 (32%)   5.1e−08                   46/66 (70%)           ig   2047 . . . 2115   13/72 (18%)   0.0002                   44/72 (61%)           ig   2150 . . . 2209   20/63 (32%)     6e−09                   45/63 (71%)           ig   2248 . . . 2309   13/65 (20%)   0.36                   38/65 (58%)           ig   2346 . . . 2407   21/65 (32%)   1.3e−06                   44/65 (68%)           ig   2441 . . . 2502   16/65 (25%)   0.022                   41/65 (63%)           ig   2537 . . . 2601   16/68 (24%)   1.1e−05                   46/68 (68%)                      
 
     Example 30  
      The NOV30 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 30A.  
                   TABLE 30A                       NOV30 Sequence Analysis                                                NOV30a, CG55784-03   SEQ ID NO: 751   3772 bp           DNA Sequence   ORF Start: ATG at 251   ORF Stop: TAA at 2549                       CTTCTCCGAGTGGGGACATTGCTGACAATCCCGGCTTCCCGAGGCGGCTAAGAACAGGCAGTTTGTGT               CGGCTGGCTGCAGATACCCAGAGGCACAAAGAGACCGAAGCCACCCGGAGGGACCCACGGACGGACAG           ATGGTAGGCGCGAACCCGAGAGGACCGGCGGAGGCTGAGCACCGAGAGCCGCCAAGGAAGAGAAACTA           ACCACAGCCAAGTTACCCCGCCGGCTTTCCTTCGCTGCGCTAAGGA   ATG AAACCCTTCCAGCTCGATC       TGCTCTTCGTCTGCTTCTTCCTCTTCAGTCAAGAGCTGGGCCTCCAGAAGAGAGGATGCTGTCTGGTG       CTGGGCTACATGGCCAAGGACAAGTTTCGGAGAATGAATGAAGGCCAAGTCTATTCCTTCAGCCAGCA       GCCCCAGGACCAGGTGGTGGTGTCGGGACAGCCAGTGACGCTACTTTGCGCCATCCCCGAATACGATG       TACCTGGTGGTAGGGAACCACCTGTCAGGGGAGCACCACCTGAAGATCCTGAGGGCAGAGCTGCAAGA       CGATGCGGTGTACGAGTGCCAGGCCATCCAGGCCGCCATCCGCTCCCGCCCCGCACGCCTCACAGTCC       TGGTGCCGCCTGATGACCCCGTCATCCTGGGGGGCCCTGTGATCAGCCTGCGTGCGGGGGACCCTCTC       AACCTCACCTGCCACGCAGACAATGCCAAGCCTGCAGCCTCCATCATCTGGTTGCGAAAGGGAGAGGT       CATCAATGGGGCCACCTACTCCAAGACCCTGCTTCGGGACGGCAAGCGGGAGAGCATCGTCAGCACCC       TCTTCATCTCCCCTGGTGACGTGGAGAATGGCCAGAGCATCGTGTGTCGTGCCACCAACAAAGCCATC       GCCACAGCCAGTGCTGGAGGACAACGTCGTCACTTTCCACTGCTCTGCAAAGGCCAACCCAGCTGTCA       GTGGACTACACGTACTTCTCAGAGCCCGTCTCCTGTGAGGTGACCAACGCCCTGGGCAGCACCAACCT       CAGCCGCACGGTTGACGTCTACTTTGGGCCCCGGATGACCACAGAACCCCAATCCTTGCTCGTGGATC       TGGGCTCTGATGCCATCTTCAGCTGCGCCTGGACCGGCAACCCATCCCTGACCATCGTCTGGATGAAG       CGGGGCTCCGGAGTGGTCCTGAGCAATGAGAAGACCCTGACCCTCAAATCCGTGCGCCAGGAGGACGC       GGGCAAGTACGTGTGCCGGGCTGTGGTGCCCCGTGTGGGAGCCGGGGAGAGAGAGGTGACCCTGACCG       TCAATGGACCCCCCATCATCTCCAGCACCCAGACCCAGCACGCCCTCCACGGCGAGAAGGGCCAGATC       AAGTGCTTCATCCGGAGCACGCCGCCGCCGGACCGCATCGCCTGGTCCTGGAAGGAGAACGTTCTGGA       GTCGGGCACATCGGGGCGCTATACGGTGGAGACCATCAGCACCGAGGAGGGCGTCATCTCCACCCTGA       CCATCAGCAACATCGTGCGGGCCGACTTCCAGACCATCTACAACTGCACGGCCTGGAACAGCTTCGGC       TCCGACACTGAGATCATCCGGCTCAAGGAGCAAGAGTCTGTGCCGATGGCCGTCATCATTGGGGTGGC       CGTAGGAGCTGGTGTGGCCTTCCTCGTCCTTATGGCAACCATCGTGGCGTTCTGCTGTGCCCGTTCCC       GCCTCTGGTCGGGAGGGTGAGGAGCACTCCACCATCAAGCAGCTGATGATGGACCGGGGTGAATTCCA       GCAAGACTCAGTCCTGAAACAGCTGGAGGTCCTCAAAGAAGAGGAGAAAGAGTTTCAGAACCTGAAGG       ACCCCACCAATGGCTACTACAGCGTCAACACCTTCAAAGAGCACCACTCAACCCCGACCATCTCCCTC       TCCAGCTGCCAGCCCGACCTGCGTCCTGCGGGTAAGCAGCGTGTGCCCACAGGCATGTCCTTCACCAA       CATCTACAGCACCCTGAGCGGCCAGGGCCGCCTCTACGACTACGGGCAGCGGTTTGTGCTGGGCATGG       GCAGCTCGTCCATCGAGCTTTGTGAGCGGGAGTTCCAGAGAGGCTCCCTCAGCGACAGCAGCTCCTTC       CTGGACACGCAGTGTGACAGCAGCGTCAGCAGCAGCGGCAAGCAGGATGGCTATGTGCAGTTCGACAA       GACCCCTGCAGCGGCGGATGCAGACTCACGTC TAA   GGATCACACACCGCGGGTGGGGACGGGCCAGGC           AAGAGGTCAGGGCACGTTCTGGTTGTCCAGGGACGAGGGGTACTTTGCAGAGGACACCAGAATTGGCC           ACTTCCAGGACAGCCTCCCAGCGCCTCTGCCACTGCCTTCCTTCGAAGCTCTGATCAAGCACAAATCT           GGGTCCCCAGGTGCTGTGTGCCAGAGGTGGGCGGGTGGGGAGACAGACAGAGGCTGCGGCTGAGTGCG           CTGTGCTTAGTGCTGGACACCCGTGTCCCCGGCCCTTTCCTGGAGGCCCCTCTACCACCTGCTCTGCC           CACAGGCACAAGTGGCAGCTATAACTCTGCTTTCATGAAACTGCGGTCCACTCTCTGGTCTCTCTGTG           GGCTCTACCCCTCACTGACCACAAGCTCTACCTACCCCTGTGCCTGTGCTCCCATACAGCCCTGGGGG           CCATACCCTGGAGGTTGACAAGCCAGAAATGGCCTTGGCTAAAGGAGCCTCTCTCTCACCAGGCTGGC           CGGGAGCCCACCCCCAATTTGTTTGGTGTTTTGTGTCCATACTCTTGCAGTTCTGTCCTTGGACTTGA           TGCCGCTGAACTCTGCGGTGGGACCGGTCCCGTCAGAGCCTGGTGTACTGGGGGGAGGGAGGGAGGAG           GGAGCCTGTGCTGACGGAGCACCTCGCCGGGTGTGCCCCTCCTGGGCTGTGTGACCCCAGCCTCCCCA           CCCACCTCCTGCTTTGTGTACTCCTCCCCTCCCCCTCAGCACAATCGGAGTTCATATAAGAAGTGCGC           GAGCTTCTCTGGTCAGGGTTCTCTGAACACTTATGGAGAGAGTGCTTCCTGGGAAGTGTGGCGTTTGA           AGGGGCTGGAGGGCAGGTCTTTAAGATGGCGAGACTGCCCTTCTCAGCTGATAAACACAAGAACGGCC           ATCCTGTCTTCAGTAAGGCTCCACGAGAAGAGAGGAAGTATATCTACACCTCAACCCTCCTAGTCACC           ACCTGAAATAATGTTAGGGACACTACTCCAACATGTTTGTTCTGTTCTTTTGTTCCTACAAAAGCCAC           AGGAAGAACCCAAGAGCTCATAGAATGCGTTGGGAACCCAAGGTTCTCTGCCCTCCTTTGATTCAATC           ATCCTAGACAATAAAGGCAGTTGATAGCTCTG                                           NOV30a, CG55784-03                       Protein Sequence   SEQ ID NO: 752   766 aa   MW at 84135.5kD                     MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVVSGQPVTLL           CAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRS       RPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGK       RESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCS       AKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTE       PQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAG       EREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTE       EGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQESVPMAVIIGVAVGAGVAFLVLMATIV       AFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEE       KEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYG       QRFVLGMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSS       SQNSDPSRPLQRRMQTHV                                     NOV30b, CG55784-01   SEQ ID NO: 753   1806 bp           DNA Sequence   ORF Start: at 1   ORF Stop: TAA at 1645                     AACAAAGCCATCCCCGGAGGAAAGGAGACGTCGGTCACCATTGACATCCAGCACCCTCCACTGGTCAA           CCTCTCGGTGGAGCCACAGCCAGTGCTGGAGGACAACGTCGTCACTTTCCACTGCTCTGCAAAGGCCA       ACCCAGCTGTCACCCAGTACAGGTGGGCCAAGCGGGGCCAGATCATCAAGGAGGCATCTGGAGAGGTG       TACAGGACCACAGTGGACTACACGTACTTCTCAGAGCCCGTCTCCTGTGAGGTGACCAAAGCCCTGGG       CAGCACCAACCTCAGCCGCACGGTTGACGTCTACTTTGGGCCCCGGATGACCACAGAACCCCAATCCT       TGCTCGTGGATCTGGGCTCTGATGCCATCTTAAGCTGCGCCTGGACCGGAAACCCATCCCTGACCATC       TGACCCTGACCGTCAATGGACCCCCCATCATCTCCAGCACCCAGACCCAGCACGCCCTCCACGGCGAG       AAGGGCCAGATCAAGTGCTTCATCCGGAGCACGCCGCCGCCGGACCGCATCGCCTGGTCCTGGAAGGA       GAACGTTCTGGAGTCGGGCACATCGGGGCGCTATACGGTGGAGACCATCAGCACCGAGGAGGGCGTCA       TCTCCACCCTGACCATCAGCAACATCGTGCGGGCCGACTTCCAGACCATCTACAACTGCACGGCCTGG       AACAGCTTCGGCTCCGACACTGAGATCATCCGGCTCAAGGAGCAAGGTTCGGAAATGAAGTCGGGAGC       CGGGCTGGAAGCAGAGTCTGTGCCGATGGCCGTCATCATTGGGGTGGCCGTAGGAGCTGGTGTGGCCT       TCCTCGTCCTTATGGCAACCATCGTGGCGTTCTGCTGTGCCCGTTCCCAGAGAAATCTCAAAGGTGTT       GTGTCAGCCAAAAATGATATCCGAGTGGAAATTGTCCACAAGGAACCAGCCTCTGGTCGGGAGGGTGA       GGAGCACTCCACCATCAAGCAGCTGATGATGGACCGGGGTGAATTCCAGCAAGACTCAGTCCTGAAAC       AGCTGGAAGGTCCTCAAAGAAGAGGAGAAGAGTTTCAGAACCTGAAGGACCCCACCAATGGCTACTAC       AGCGTCAACACCTTCAAAGAGCACCACTCAACCCCGACCATCTCCCTCTCCAGCTGCCAGCCCGACCT       GCGTCCTGCGGGCAAGCAGCGTGTGCCCACAGGCATGTCCTTCACCAACATCTACAGCACCCTGAGCG       GCCAGGGCCGCCTCTACGACTACGGGCAGCGGTTTGTGCTGGGCATGGGCAGCTCGTCCATCGAGCTT       TGTGAGCGGGAGTTCCAGAGAGGCTCCCTCAGCGACAGCAGCTCCTTCCTGGACACGCAGTGTGACAG       CAGCGTCAGCAGCAGCGGCAAGCAGGATGGCTATGTGCAGTTCGACAAGGCCAGCAAGGCTTCTGCTT       CCTCCTCCCACCACTCCCAGTCCTCGTCCCAGAACTCTGACCCCAGTCGACCCCTGCAGCGGCGGATG       CAGACTCACGTC TAA   GGATCACACACCGCGGGTGGGGACGGGCCAGGGAAGAGGTCAGGGCACGTTCT           GGTTGTCCAGGGACTGTGGGGTACTTTACAGAGGACACCAGAATGGCCCACTTCCAGGACAGCCTCCC           AGCGCCTCTGCCACTGCCTTCCTTCGAAGCTCTGATCA                                           NOV30b, CG55784-01                       Protein Sequence   SEQ ID NO: 754   548 aa   MW at 59933.8kD                     NKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEV           YRTTVDYTYFSEPVSCEVTKALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAILSCAWTGNPSLTI       VWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGE       KGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVPADFQTIYNCTAW       NSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGV       VSAKNDIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYY       SVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIEL       CEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRM       QTHV                                     NOV30c, 312000579   SEQ ID NO: 755   1630 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCACCAACAAAGCCATCCCCGGAGGAAAGGAGACGTCGGTCACCATTGACATCCAGCACC           CTCCACTGGTCAACCTCTCGGTGGAGCCACAGCCAGTGCTGGAGGACAACGTCGTCACTTTCCACTGC       TCTGCAAAGGCCAACCCAGCTGTCACCCAGTACAGGTGGGCCAAGCGGGGCCAGATCATCAAGGAGGC       ATCTGGAGAGGTGTACAGGACCACAGTGGACTACACGTACTTCTCAGAGCCCGTCTCCTGTGAGGTGA       CCAACGCCCTGGGCAGCACCAACCTCAGCCGCACGGTTGACGTCTACTTTGGGCCCCGGATGACCACA       GAACCCCAATCCTTGCTCGTGGATCTGGGCTCTGATGCCATCTTCAGCTGCGCCTGGACCGGCAACCC       ATCCCTGACCATCGTCTGGATGAAGCGGGGCTCCGGAGTGGTCCTGAGCAATGAGAAGACCCTGACCC       TCAAATCCGTGCGCCAGGAGGACGCGGGCAAGTACGTGTGCCGGGCTGTGGTGCCCCGTGTGGGAGCC       GGGGAGAGAGAGGTGACCCTGACCGTCAATGGACCCCCCATCATCTCCAGCACCCAGACCCAGCACGC       CCTCCACGGCGAGAAGGGCCAGATCAAGTGCTTCATCCGGAGCACGCCGCCGCCGGACCGCATCGCCT       GGTCCTGGAAGGAGAACGTTCTGGAGTCGGGCACATCGGGGCGCTATACGGTGGAGACCATCAGCACC       GAGGAGGGCGTCATCTCCACCCTGACCATCAGCAACATCGTGCGGGCCGACTTCCAGACCATCTACAA       CTGCACGGCCTGGAACAGCTTCGGCTCCGACACTGAGATCATCCGGCTCAAGGAGCAAGAGTCTGTGC       CGATGGCCGTCATCATTGGGGTGGCCGTAGGAGCTGGTGTGGCCTTCCTCGTCCTTATGGCAACCATC       GTGGCGTTCTGCTGTGCCCGTTCCCAGAGAAATCTCAAAGGTGTTGTGTCAGCCAAAAATGATATCCG       AGTGGAAATTGTCCACAAGGAACCAGCCTCTGGTCGGGAGGGTGAGGAGCACTCCACCATCAAGCAGC       TGATGATGGACCGGGGTGAATTCCAGCAAGACTCAGTCCTGAAACAGCTGGAGGTCCTCAAAGAAGAG       GAGAAGAGTTTCAGAACCTGAAGGACCCCACCAATGGCTACTACAGCGTCAACACCTTCAAAAGAGCA       CCACTCAACCCCGACCATCTCCCTCTCCAGCTGCCAGCCCGACCTGCGTCCTGCGGGTAAGCAGCGTG       TGCCCACAGGCATGTCCTTCACCAACATCTACAGCACCCTGAGCGGCCAGGGCCGCCTCTACGACTAC       GGGCAGCGGTTTGTGCTGGGCATGGGCAGCTCGTCCATCGAGCTTTGTGAGCGAAAGTTCCAGAGAGG       CTCCCTCAGCGACAGCAGCTCCTTCCTGGACACGCAGTGTGACAGCAGCGTCAGCAGCAGCGGCAAGC       AGGATGGCTATGTGCAGTTCGACAAGGCCAGCAAGGCTTCTGCTTCCTCCTCCCACCACTCCCAGTCC       TCGTCCCAGAACTCTGACCCCAGTCGACCCCTGCAGCGGCGGATGCAGACTCACGTCCCCGGGGGC                                         NOV30c, 312000579                       Protein Sequence   SEQ ID NO: 756   543 aa   MW at 59393.1kD                     TGSTNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEA           SGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRNTTEPQSLLVDLGSDAIFSCAWTGNP       SLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHA       LHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYN       CTAWNSFGSDTEIIRLKEQESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIR       VEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEH       HSTPTISLSSCQPDLRPAGKQRVPTGMSFTNTYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRG                                     NOV30d, 311333341   SEQ ID NO: 757   1036 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCACCAACAAAGCCATCCCCGGAGGAAAGGAGACGTCGGTCACCATTGACATCCAGCACC           CTCCACTGGTCAACCTCTCGGTGGAGCCACAGCCAGTGCTGGAGGACAACGTCGTCACTTTCCACTGC       TCTGCAAAGGCCAACCCAGCTGTCACCCAGTACAGGTGGGCCAAGCGGGGCCAGATCATCAAGGAGGC       ATCTGGAGAGGTGTACAGGACCACAGTGGACTACACGTACTTCTCAGAGCCCGTCTCCTGTGAGGTGA       CCAACGCCCTGGGCAGCACCAACCTCAGCCGCACGGTTGACGTCTACTTTGGGCCCCGGATGACCACA       GAACCCCAATCCTTGCTCGTGGATCTGGGCTCTGATGCCATCTTCAGCTGCGCCTGGACCGGCAACCC       ATCCCTGACCATCGTCTGGATGAAGCGGGGCTCCGGAGTGGTCCTGAGCAATGAGAAGACCCTGACCC       TCAAATCCGTGCGCCAGGAGGACGCGGGCAAGTACGTGTGCCGGGCTGTGGTGCCCCGTGTGGGAGCC       GGGGAGAGAGAGGTGACCCTGACCGTCAATGGACCCCCCATCATCTCCAGCACCCAGACCCAGCACGC       CCTCCACGGCGAGAAGGGCCAGATCAAGTGCTTCATCCGGAGCACGCCGCCGCCGGACCGCATCGCCT       GGTCCTGGAAGGAGAACGTTCTGGAGTCGGGCACATCGGGGCGCTATACGGTGGAGACCATCAGCACC       GAGGAGGGCGTCATCTCCACCCTGACCATCAGCAACATCGTGCGGGCCGACTTCCAGACCATCTACAA       CTGCACGGCCTGGAACAGCTTCGGCTCCGACACTGAGATCATCCGGCTCAAGGAGCAAGAGTCTGTGC       CGATGGCCGTCATCATTGGGGTGGCCGTAGGAGCTGGTGTGGCCTTCCTCGTCCTTATGGCAACCATC       GTGGCGTTCTGCTGTGCCCGTTCCCAGAGAAATCTCAAAGGTGTTGTGTCAGCCAAAAATGATATCCG       AGTGGAACCCGGGGGC                                         NOV30d, 311333341                       Protein Sequence   SEQ ID NO: 758   345 aa   MW at 37329.1kD                     TGSTNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEA           SGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNP       SLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHA       LHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYN       CTAWNSFGSDTEIIRLKEQESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIR       VEPGG                                     NOV30e, 311333338   SEQ ID NO: 759   1072 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCACCAACAAAGCCATCCCCGGAGGAAAGGAGACGTCGGTCACCATTGACATCCAGCACC           CTCCACTGGTCAACCTCTCGGTGGAGCCACAGCCAGTGCTGGAGGACAACGTCGTCACTTTCCACTGC       TCTGCAAAGGCCAACCCAGCTGTCACCCAGTACAGGTGGGCCAAGCGGGGCCAGATCATCAAGGAGGC       ATCTGGAGAGGTGTACAGGACCACAGTGGACTACACGTACTTCTCAGAGCCCGTCTCCTGTGAGGTGA       CCAACGCCCTGGGCAGCACCAACCTCAGCCGCACGGTTGACGTCTACTTTGGGCCCCGGATGACCACA       GAACCCCAATCCTTGCTCGTGGATCTGGGCTCTGATGCCATCTTCAGCTGCGCCTGGACCGGCAACCC       ATCCCTGACCATCGTCTGGATGAAGCGGGGCTCCGGAGTGGTCCTGAGCAATGAGAAGACCCTGACCC       TCAAATCCGTGCGCCAGGAGGACGCGGGCAAGTACGTGTGCCGGGCTGTGGTGCCCCGTGTGGGAGCC       GGGGAGAGAGAGGTGACCCTGACCGTCAATGGACCCCCCATCATCTCCAGCACCCAGACCCAGCACGC       CCTCCACGGCGAGAAGGGCCAGATCAAGTGCTTCATCCGGAGCACGCCGCCGCCGGACCGCATCGCCT       GGTCCTGGAAGGAGAACGTTCTGGAGTCGGGCACATCGGGGCGCTATACGGTGGAGACCATCAGCACC       GAGGAGGGCGTCATCTCCACCCTGACCATCAGCAACATCGTGCGGGCCGACTTCCAGACCATCTACAA       CTGCACGGCCTGGAACAGCTTCGGCTCCGACACTGAGATCATCCGGCTCAAGGAGCAAGGTTCGGAAA       TGAAGTCGGGAGCCGGGCTGGAAGCAGAGTCTGTGCCGATGGCCGTCATCATTGGGGTGGCCGTAGGA       GCTGGTGTGGCCTTCCTCGTCCTTATGGCAACCATCGTGGCGTTCTGCTGTGCCCGTTCCCAGAGAAA       TCTCAAAGGTGTTGTGTCAGCCAAAAATGATATCCGAGTGGAACCCGGGGGC                                         NOV30e, 311333338                       Protein Sequence   SEQ ID NO: 760   357 aa   MW at 38447.3kD                     TGSTNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEA           SGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNP       SLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHA       LHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYN       CTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRN       LKGVVSAKNDIRVEPGG                                     NOV30f, 311346885   SEQ ID NO: 761   616 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCGAAATTGTCCACAAGGAACCAGCCTCTGGTCGGGAGGGTGAGGAGCACTCCACCATCA           AGCAGCTGATGATGGACCGGGGTGAATTCCAGCAAGACTCAGTCCTGAAACAGCTGGAGGTCCTCAAA       GAAGAGGAGAAAGAGTTTCAGAACCTGAAGGACCCCACCAATGGCTACTACAGCGTCAACACCTTCAA       AGAGCACCACTCAACCCCGACCATCTCCCTCTCCAGCTGCCAGCCCGACCTGCGTCCTGCGGGCAAGC       AGCGTGTGCCCACAGGCATGTCCTTCACCAACATCTACAGCACCCTGAGCGGCCAGGGCCGCCTCTAC       GACTACGGGCAGCGGTTTGTGCTGGGCATGGGCAGCTCGTCCATCGAGCTTTGTGAGCGGGAGTTCCA       GCAAGCAGGATGGCTATGTGCAGTTCGACAAGGCCAGCAAGGCTTCTGCTTCCTCCTCCCACCACTCC       GGGC                                         NOV30f, 311346885                       Protein Sequence   SEQ ID NO: 762   205 aa   MW at 22667.6kD                     TGSEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFK           EHHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNTYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQ       RGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHVPG                                     NOV30g, 311333299   SEQ ID NO: 763   1666 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCACCAACAAAGCCATCCCCGGAGGAAAGGAGACGTCGGTCACCATTGACATCCAGCACC           CTCCACTGGTCAACCTCTCGGTGGAGCCACAGCCAGTGCTGGAGGACAACGTCGTCACTTTCCACTGC       TCTGCAAAGGCCAACCCAGCTGTCACCCAGTACAGGTGGGCCAAGCGGGGCCAGATCATCAAGGAGGC       ATCTGGAGAGGTGTACAGGACCACAGTGGACTACACGTACTTCTCAGAGCCCGTCTCCTGTGAGGTGA       CCAACGCCCTGGGCAGCACCAACCTCAGCCGCACGGTTGACGTCTACTTTGGGCCCCGGATGACCACA       GAACCCCAATCCTTGCTCGTGGATCTGGGCTCTGATGCCATCTTCAGCTGCGCCTGGACCGGCAACCC       ATCCCTGACCATCGTCTGGATGAAGCGGGGCTCCGGAGTGGTCCTGAGCAATGAGAAGACCCTGACCC       TCAAATCCGTGCGCCAGGAGGACGCGGGCAAGTACGTGTGCCGGGCTGTGGTGCCCCGTGTGGGAGCC       GGGGAGAGAGAGGTGACCCTGACCGTCAATGGACCCCCCATCATCTCCAGCACCCAGACCCAGCACGC       CCTCCACGGCGAGAAGGGCCAGATCAAGTGCTTCATCCGGAGCACGCCGCCGCCGGACCGCATCGCCT       GGTCCTGGAAGGAGAACGTTCTGGAGTCGGGCACATCGGGGCGCTATACGGTGGAGACCATCAGCACC       GAGGAGGGCGTCATCTCCACCCTGACCATCAGCAACATCGTGCGGGCCGACTTCCAGACCATCTACAA       CTGCACGGCCTGGAACAGCTTCGGCTCCGACACTGAGATCATCCGGCTCAAGGAGCAAGGTTCGGAAA       TGAAGTCGGGAGCCGGGCTGGAAGCAGAGTCTGTGCCGATGGCCGTCATCATTGGGGTGGCCGTAGGA       GCTGGTGTGGCCTTCCTCGTCCTTATGGCAACCATCGTGGCGTTCTGCTGTGCCCGTTCCCAGAGAAA       TCTCAAAGGTGTTGTGTCAGCCAAAAATGATATCCGAGTGGAAATTGTCCACAAGGAACCAGCCTCTG       GTCGGGAGGGTGAGGAGCACTCCACCATCAAGCAGCTGATGATGGACCGGGGTGAATTCCAGCAAGAC       TCAGTCCTGAAACAGCTGGAGGTCCTCAAAGAAGAGGAGAAAGAGTTTCAGAACCTGAAGGACCCCAC       CAATGGCTACTACAGCGTCAACACCTTCAAAGAGCACCACTCAACCCCGACCATCTCCCTCTCCAGCT       GCCAGCCCGACCTGCGTCCTGCGGGCAAGCAGCGTGTGCCCACAGGCATGTCCTTCACCAACATCTAC       AGCACCCTGAGCGGCCAGGGCCGCCTCTACGACTACGGGCAGCGGTTTGTGCTGGGCATGGGCAGCTC       GTCCATCGAGCTTTGTGAGCGGGAGTTCCAGAGAGGCTCCCTCAGCGACAGCAGCTCCTTCCTGGACA       CGCAGTGTGACAGCAGCGTCAGCAGCAGCGGCAAGCAGGATGGCTATGTGCAGTTCGACAAGGCCAGC       AAGGCTTCTGCTTCCTCCTCCCACCACTCCCAGTCCTCGTCCCAGAACTCTGACCCCAGTCGACCCCT       GCAGCGGCGGATGCAGACTCACGTCCCCGGGGGC                                         NOV30g, 311333299                       Protein Sequence   SEQ ID NO: 764   555 aa   MW at 60511.3kD                     TGSTNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEA           SGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNP       SLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCPAVVPRVGAGEREVTLTVNGPPIISSTQTQHA       LHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYN       CTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRN       LKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPT       NGYYSVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSS       SIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPL       QRRMQTHVPGG                                     NOV30h, CG55784-02   SEQ ID NO: 765   891 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     AACAAAGCCATCCCCGGAGGAAAGGAGACGTCGGTCACCATTGACATCCAGCACCCTCCACTGGTCAA           CCTCTCGGTGGAGCCACAGCCAGTGCTGGAGGACAACGTCGTCACTTTCCACTGCTCTGCAAAGGCCA       ACCCAGCTGTCACCCAGTACAGGTGGGCCAAGCGGGGCCAGATCATCAAGGAGGCATCTGGAGAGGTG       TACAGGACCACAGTGGACTACACGTACTTCTCAGAGCCCGTCTCCTGTGAGGTGACCAACGCCCTGGG       CAGCACCAACCTCAGCCGCACGGTTGACGTCTACTTTGGGCCCCGGATGACCACAGAACCCCAATCCT       TGCTCGTGGATCTGGGCTCTGATGCCATCTTCAGCTGCGCCTGGACCGGCAACCCATCCCTGACCATC       GTCTGGATGAAGCGGGGCTCCGGAGTGGTCCTGAGCAATGAGAAGACCCTGACCCTCAAATCCGTGCG       CCAGGAGGACGCGGGCAAGTACGTGTGCCGGGCTGTGGTGCCCCGTGTGGGAGCCGGGGAGAGAGAGG       TGACCCTGACCGTCAATGGACCCCCCATCATCTCCAGCACCCAGACCCAGCACGCCCTCCACGGCGAG       AAGGGCCAGATCAAGTGCTTCATCCGGAGCACGCCGCCGCCGGACCGCATCGCCTGGTCCTGGAAGGA       GAACGTTCTGGAGTCGGGCACATCGGGGCGCTATACGGTGGAGACCATCAGCACCGAGGAGGGCGTCA       TCTCCACCCTGACCATCAGCAACATCGTGCGGGCCGACTTCCAGACCATCTACAACTGCACGGCCTGG       AACAGCTTCGGCTCCGACACTGAGATCATCCGGCTCAAGGAGCAAGGTTCGGAAATGAAGTCGGGAGC       CGGGCTG                                         NOV30h, CG55784-02                       Protein Sequence   SEQ ID NO: 766   297 aa   MW at 32432.3kD                     NKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEV           YRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTI       VWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCEAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGE       KGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAW       NSFGSDTEIIRLKEQGSEMKSGAGL                                     NOV30i,                   SNP13376439 of   SEQ ID NO: 767   1806 bp       CG55784-01,   ORF Start: at 1   ORF Stop: TAA at 1645       DNA Sequence   SNP Pos: 1305   SNP Change: C to T                     AACAAAGCCATCCCCGGAGGAAAGGAGACGTCGGTCACCATTGACATCCAGCACCCTCCACTGGTCAA           CCTCTCGGTGGAGCCACAGCCAGTGCTGGAGGACAACGTCGTCACTTTCCACTGCTCTGCAAAGGCCA       ACCCAGCTGTCACCCAGTACAGGTGGGCCAAGCGGGGCCAGATCATCAAGGAGGCATCTGGAGAGGTG       TACAGGACCACAGTGGACTACACGTACTTCTCAGAGCCCGTCTCCTGTGAGGTGACCAAAGCCCTGGG       CAGCACCAACCTCAGCCGCACGGTTGACGTCTACTTTGGGCCCCGGATGACCACAGAACCCCAATCCT       TGCTCGTGGATCTGGGCTCTGATGCCATCTTAAGCTGCGCCTGGACCGGCAACCCATCCCTGACCATC       GTCTGGATGAAGCGGGGCTCCGGAGTGGTCCTGAGCAATGAGAAGACCCTGACCCTCAAATCCGTGCG       CCAGGAGGACGCGGGCAAGTACGTGTGCCGGGCTGTGGTGCCCCGTGTGGGAGCCGGGGAGAGAGAGG       TGACCCTGACCGTCAATGGACCCCCCATCATCTCCAGCACCCAGACCCAGCACGCCCTCCACGGCGAG       AAGGGCCAGATCAAGTGCTTCATCCGGAGCACGCCGCCGCCGGACCGCATCGCCTGGTCCTGGAAGGA       GAACGTTCTGGAGTCGGGCACATCGGGGCGCTATACGGTGGAGACCATCAGCACCGAGGAGGGCGTCA       TCTCCACCCTGACCATCAGCAACATCGTGCGGGCCGACTTCCAGACCATCTACAACTGCACGGCCTGG       AACAGCTTCGGCTCCGACACTGAGATCATCCGGCTCAAGGAGCAAGGTTCGGAAATGAAGTCGGGAGC       CGGGCTGGAAGCAGAGTCTGTGCCGATGGCCGTCATCATTGGGGTGGCCGTAGGAGCTGGTGTGGCCT       TCCTCGTCCTTATGGCAACCATCGTGGCGTTCTGCTGTGCCCGTTCCCAGAGAAATCTCAAAGGTGTT       GTGTCAGCCAAAAATGATATCCGAGTGGAAATTGTCCACAAGGAACCAGCCTCTGGTCGGGAGGGTGA       GGAGCACTCCACCATCAAGCAGCTGATGATGGACCGGGGTGAATTCCAGCAAGACTCAGTCCTGAAAC       AGCTGGAGGTCCTCAAAGAAGAGGAGAAAGAGTTTCAGAACCTGAAGGACCCCACCAATGGCTACTAC       AGCGTCAACACCTTCAAAGAGCACCACTCAACCCCGACCATCTCCCTCTCCAGCTGCCAGCCCGACCT       GCGTCCTGCGGG   T   AAGCAGCGTGTGCCCACAGGCATGTCCTTCACCAACATCTACAGCACCCTGAGCG       GCCAGGGCCGCCTCTACGACTACGGGCAGCGGTTTGTGCTGGGCATGGGCAGCTCGTCCATCGAGCTT       TGTGAGCGGGAGTTCCAGAGAGGCTCCCTCAGCGACAGCAGCTCCTTCCTGGACACGCAGTGTGACAG       CAGCGTCAGCAGCAGCGGCAAGCAGGATGGCTATGTGCAGTTCGACAAGGCCAGCAAGGCTTCTGCTT       CCTCCTCCCACCACTCCCAGTCCTCGTCCCAGAACTCTGACCCCAGTCGACCCCTGCAGCGGCGGATG       CAGACTCACGTC TAA   GGATCACACACCGCGGGTGGGGACGGGCCAGGGAAGAGGTCAGGGCACGTTCT           GGTTGTCCAGGGACTGTGGGGTACTTTACAGAGGACACCAGAATGGCCCACTTCCAGGACAGCCTCCC           AGCGCCTCTGCCACTGCCTTCCTTCGAAGCTCTGATCA                                           Nov30i,                       SNP1 3376439 of       CG55784-01,   SEQ ID NO: 768       MW at 59933.8kD       Protein Sequence   SNP Pos: 435   548 aa   SNP Change: Gly to Gly                     NKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEV           YRTTVDYTYFSEPVSCEVTKALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAILSCAWTGNPSLTI       VWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGE       KGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAW       NSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGV       VSAKNDIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYY       SVNTFKEHHSTPTISLSSCQPDLRPA   G   KQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIEL       CEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRM       QTHV                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 30B.  
                   TABLE 30B                       Comparison of the NOV30 protein sequences.                                            NOV30a   MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVV           NOV30b   ------------------------------------------------------------       NOV30c   ------------------------------------------------------------       NOV30d   ------------------------------------------------------------       NOV30e   ------------------------------------------------------------       NOV30f   ------------------------------------------------------------       NOV30g   ------------------------------------------------------------       NOV30h   ------------------------------------------------------------               NOV30a   SGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQ       NOV30b   ------------------------------------------------------------       NOV30c   ------------------------------------------------------------       NOV30d   ------------------------------------------------------------       NOV30e   ------------------------------------------------------------       NOV30f   ------------------------------------------------------------       NOV30g   ------------------------------------------------------------       NOV30h   ------------------------------------------------------------               NOV30a   DDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAAS       NOV30b   -------------------------------------------------------------       NOV30c   -------------------------------------------------------------       NOV30d   -------------------------------------------------------------       NOV30e   -------------------------------------------------------------       NOV30f   -------------------------------------------------------------       NOV30g   -------------------------------------------------------------       NOV30h   -------------------------------------------------------------               NOV30a   IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKET       NOV30b   --------------------------------------------------NKAIPGGKET       NOV30c   ----------------------------------------------TGSTNKAIPGGKET       NOV30d   ----------------------------------------------TGSTNKAIPGGKET       NOV30e   ----------------------------------------------TGSTNKAIPGGKET       NOV30f   -------------------------------------------------TGSEIVHKEPA       NOV30g   ----------------------------------------------TGSTNKAIPGGKET       NOV30h   --------------------------------------------------NKAIPGGKET               NOV30a   SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR       NOV30b   SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR       NOV30c   SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR       NOV30d   SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR       NOV30e   SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR       NOV30f   SGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHH       NOV30g   SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR       NOV30h   SVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR               NOV30a   TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG       NOV30b   TTVDYTYFSEPVSCEVTKALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAILSCAWTG       NOV30c   TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG       NOV30d   TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG       NOV30e   TTVDYTYFSEPVSCEVTNALGSThLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG       NOV30f   STPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGR----LYDYGQRFVLGMGSS-       NOV30g   TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG       NOV30h   TTVDYTYFSEPVSCEVTNALGSTNLSRnTDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTG               NOV30a   NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCBAVVPRVGAGEREVTLTVNGPP       NOV30b   NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP       NOV30c   NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP       NOV30d   NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP       NOV30e   NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP       NOV30f   SIELCEREFQRGS---LSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQ-       NOV30g   NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP       NOV30h   NPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPP               NOV30a   IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI       NOV30b   IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI       NOV30c   IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI       NOV30d   IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI       NOV30e   IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVI       NOV30f   -S-SSQNSDPSRPLQRRMQTHVPGG-----------------------------------       NOV30g   IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETTSTEEGVI       NOV30h   IISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETTSTEEGVI               NOV30a   STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQ------------ESVPMAVIIGV       NOV30b   STLTISNIVPADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV       NOV30c   STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQ------------ESVPMAVIIGV       NOV30d   STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQ------------ESVPMAVIIGV       NOV30e   STLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV       NOV30f   ------------------------------------------------------------       NOV30g   STLTISNIVPADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGV       NOV30h   STLTISNIVHADFQTIYNCTAWNSFGSDTEIIRLKEQG-------------------SEM               NOV30a   AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ       NOV30b   AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ       NOV30c   AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ       NOV30d   AVGAGVAFLVLMATIVAFCCARSQHNLKGVVSAKNDIRVEPGG-----------------       NOV30e   AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEPGG-----------------       NOV30f   ------------------------------------------------------------       NOV30g   AVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQ       NOV30h   KSGAGL------------------------------------------------------               NOV30a   LMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPD       NOV30b   LMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPD       NOV30c   LMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPD       NOV30d   ------------------------------------------------------------       NOV30e   ------------------------------------------------------------       NOV30f   ------------------------------------------------------------       NOV30g   LMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPD       NOV30h   ------------------------------------------------------------               NOV30a   LRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSS       NOV30b   LRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSS       NOV30c   LRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSS       NOV30d   ------------------------------------------------------------       NOV30e   ------------------------------------------------------------       NOV30f   ------------------------------------------------------------       NOV30g   LRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSS       NOV30h   ------------------------------------------------------------               NOV30a   SFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV--       NOV30b   SFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV--       NOV30c   SFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHVPG       NOV30d   ------------------------------------------------------------       NOV30e   ------------------------------------------------------------       NOV30f   ------------------------------------------------------------       NOV30g   SFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHVPG       NOV30h   ------------------------------------------------------------               NOV30a   -       NOV30b   -       NOV30c   G       NOV30d   -       NOV30e   -       NOV30f   -       NOV30g   G       NOV30h   -               NOV30a   (SEQ ID NO: 752)       NOV30b   (SEQ ID NO: 754)       NOV30c   (SEQ ID NO: 756)       NOV30d   (SEQ ID NO: 758)       NOV30e   (SEQ ID NO: 760)       NOV30f   (SEQ ID NO: 762)       NOV30g   (SEQ ID NO: 764)       NOV30h   (SEQ ID NO: 766)                  
 
      Further analysis of the NOV30a protein yielded the following properties shown in Table 30C.  
               TABLE 30C                       Protein Sequence Properties NOV30a                                        SignalP analysis:   Cleavage site between residues 24 and 25       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 7; pos. chg 1; neg. chg 1           H-region:   length 11; peak value 13.09           PSG score:   8.69                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −3.29           possible cleavage site: between 17 and 18                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 2           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 524-540               −10.40                             PERIPHERAL   Likelihood = 1.54 (at 65)                         ALOM score: −10.40 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 531           Charge difference: 5.0 C(3.0)-N(−2.0)           C &gt; N: C-terminal side will be inside                 &gt;&gt;&gt;Caution: Inconsistent mtop result with signal peptide       &gt;&gt;&gt; membrane topology: type 1b (cytoplasmic tail 524 to 766)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   8.25           Hyd Moment(95):   6.93   G content:   0           D/E content:   2   S/T content:   1                         Score: −6.35       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: KRGCCLVLGYMAKDKFR at 24           content of basic residues: 10.2%           NLS Score: 0.02       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs:                         Leucine zipper pattern (PS00029): *** found ***            LLFVCFFLFSQELGLQKRGCCL at 8                 none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 55.5       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         39.1%: nuclear           21.7%: cytoplasmic           17.4%: mitochondrial            8.7%: vesicles of secretory system            4.3%: vacuolar            4.3%: peroxisomal            4.3%: endoplasmic reticulum                 &gt;&gt; prediction for CG55784-03 is nuc (k = 23)                  
 
      A search of the NOV30a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 30D.  
               TABLE 30D                          Geneseq Results for NOV30a                                         NOV30a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value                                             ABG96273   Human immunoglobulin superfamily   1 . . . 766   766/766   (100%)   0.0           protein IGSFP-11 -  Homo sapiens , 766   1 . . . 766   766/766   (100%)           aa. [WO200272794-A2, 19-SEP-2002]       ABU58692   Human PRO polypeptide #293 -  Homo     1 . . . 557   554/569   (97%)   0.0             sapiens , 600 aa. [US2003027272-A1,   1 . . . 569   555/569   (97%)           06-FEB-2003]       ABU57223   Human PRO polypeptide #293 -  Homo     1 . . . 557   554/569   (97%)   0.0             sapiens , 600 aa. [US2003027280-A1,   1 . . . 569   555/569   (97%)           06-FEB-2003]       ABU56228   Human secreted/transmembrane   1 . . . 557   554/569   (97%)   0.0           protein, PRO19814 -  Homo sapiens ,   1 . . . 569   555/569   (97%)           600 aa. [US2003022298-A1, 30-JAN-           2003]       ABU10802   Human secreted/transmembrane   1 . . . 557   554/569   (97%)   0.0           protein #293 -  Homo sapiens , 600 aa.   1 . . . 569   555/569   (97%)           [US2002127584-A1, 12-SEP-2002]                  
 
      In a BLAST search of public sequence databases, the NOV30a protein was found to have homology to the proteins shown in the BLASTP data in Table 30E.  
               TABLE 30E                          Public BLASTP Results for NOV30a                                         NOV30a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q8IZU9   NPEH2 -  Homo sapiens  (Human),   1 . . . 766   766/778 (98%)   0.0           778 aa.   1 . . . 778   766/778 (98%)       Q96JG0   Hypothetical protein KIAA1867 -   1 . . . 766   766/778 (98%)   0.0             Homo sapiens  (Human), 779 aa   2 . . . 779   766/778 (98%)           (fragment).       AAO41835   Membrane protein mKirre -  Mus     1 . . . 766   750/766 (97%)   0.0             musculus  (Mouse), 766 aa.   1 . . . 766   762/766 (98%)       Q8BR86   Weakly similar to NEPH1 -  Mus     1 . . . 766   750/778 (96%)   0.0             musculus  (Mouse), 778 aa.   1 . . . 778   762/778 (97%)       Q8BGQ5   Weakly similar to NEPH1 -  Mus     1 . . . 591   575/591 (97%)   0.0             musculus  (Mouse), 612 aa.   1 . . . 591   588/591 (99%)                  
 
      PFam analysis predicts that the NOV30a protein contains the domains shown in the Table 30F.  
               TABLE 30F                          Domain Analysis of NOV30a                                             Identities/                       Similarities           Pfam   NOV30a   for the   Expect           Domain   Match Region   Matched Region   Value                       ig    62 . . . 129   14/72 (19%)   0.00022                   41/72 (57%)           ig   163 . . . 229   13/69 (19%)   0.0045                   43/69 (62%)           ig   349 . . . 400   15/55 (27%)   1.6e−06                   39/55 (71%)           ig   433 . . . 501   12/70 (17%)   0.31                   45/70 (64%)                      
 
     Example 31  
      The NOV31 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 31A.  
                   TABLE 31A                       NOV31 Sequence Analysis                                                NOV31a, CG55790-02   SEQ ID NO: 769   8250 bp           DNA Sequence   ORF Start: ATG at 4   ORF Stop: TAG at 1423                       ACC   ATG CGGCTGGGCAGTCCTGGACTGCTCTTCCTGCTCTTCAGCAGCCTTCGAGCTGATACTCAGGA           GAAGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGCTCAGCTGCGCTTGCCCTGAAGGAAGCCGTT       TTGATTTAAATGATGTTTACGTATATTGGCAAACCAGTGAGTCGAAAACCGTGGTGACCTACCACATC       CCACAGAACAGCTCCTTGGAAAACGTGGACAGCCGCTACCGGAACCGAGCCCTGATGTCACCGGCCGG       CATGCTGCGGGCGACTTCTCCCTGCGCTTGTTCAACGTCACCCCCCCAGGACGAGCAGAAGTTTCACT       GCCTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTTTTGAGCGTTGAGGTTACACTGCATGTGGCA       GCAAACTTCAGCGTGCCCGTCGTCAGCGCCCCCCACAGCCCCTCCCAGGATGAGCTCACCTTCACGTG       TACATCCATAAACGGCTACCCCAGGCCCAACGTGTACTGGATCAATAAGACGGACAACAGCCTGCTGG       ACCAGGCTCTGCAGAATGACACCGTCTTCTTGAACATGCGGGGCTTGTATGACGTGGTCAGCGTGCTG       AGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTGCATAGAGAACGTGCTTCTGCAGCAGAACCT       GACTGTCGGCAGCCAGACAGGAAATGACATCGGAGAGAGAGACAAGATCACAGAGAATCCAGTCAGTA       CCGGCGAGAAAAACGCGGCCACGTGGAGCATCCTGGCTGTCCTGTGCCTGCTTGTGGTCGTGGCGGTG       GCCATAGGCTGGGTGTGCAGGGACCGATGCCTCCAACACAGCTATGCAGGTGCCTGGGCTGTGAGTCC       GGAGACAGAGCTCACTGGTGAGTTTGCCGTGGGAAGCAGCAGGTTCTGGGGGGCCCAGGGGAGGCTTG       GCTGCCAGCTGTCTTTCAGAGTTTCAAAAAACTTTCAAAAGGCAAAAGTCCCTTGCCTTGAACAACTG       TTGTTCCTGGAGACGCAGCGAAGCCCTCGATGGTGCGCATGGCATTTCCTGCAGCCTCCCCTTGGCAT       GGGATGGCATCCTGGTGTGCACTTTGTCACACTGCGATGGGATTTTCCCAACATGCACAGAAGCAGAG       AGACGAGTGCTAGACCCCCGCGCTCCCCAGTGCCCAGCCCCGACCAGGGTGTCCAGGGCGGGTCCAGG       CACCGGCGCCCAGCCCCCATGGGGTGTCCGGAGTGGGTCCAGGCACCGGCGCCCAGCCCCCGTGGGGT       GTCCAGGGCGGGTCCAGGCACCGGCGCCCAGCCCCTGTGGGGTGTCCGGAGTGGGTCCGGGCACCGCC       AGCTTCTCTCTGTGGCAGCCACTCCTGCAGCTCTCGTTTGCCCCTCAGTTCCAGGAGCAACA TAG   ATG           TGGATTCCTGTCCAATTTGGGAAAAATGTCCACACACGGTCACCCACCTGGCAGGTGCCTCTGGCTGC           AAGGGGCGCTGGGCTTCGCAGGCAGGCCAGCCGGGCTCCCCGCCATGGGCCAGGATCCCCTCCGAGCG           CTGTTTGCCGCCCAGGAGAAGGGGTTCCCCGGGGACAGTGGGCTCAGGGTGTGCGCAGCCACCATGCT           GTGGTGTCACCTGTGGACCCAGGCGAGCTGATGGCCGACCGCAGAAACGCACTTCCAAGGCCAGGTCG           GCCCATCCAGATGATGCAGGAACACAGCTTGCTAAAAACACGGCCGGCCTGTTCCCGTCGGAGCCAGT           CGAAGTTCCCTGAACAGGCCGCTGTTTCCGAAGCTTTAAACCCTGTGTTTCCACCAAGCTGAGTCCTG           AGAAAACCGACGTCTGCCTGCAGAAGGGAAAGGGGTGCTTCATGTTCCTCTCTCTCCTTCATCTCCCT           TCCAAGGCCACGTTTGACCGGAGCTCACCGCCCAGAGCGTGGACAGGGCTTCCGTGAGACGCCACCGT           GAGAGGCCAGGTGGCAGCTTGAGCATGGACTCCCAGACTGCAGGGGAGCACTTGGGGCAGCCCCCAGA           AGGACCACTGCTGGATCCCAGGGAGAACCTGCTGGCGTTGGCTGTGATCCTGGAATGAGGCCCTTTCA           AAAGCGTCATCCACACCAAAGGCAAATGTCCCCAAGTGAGTGGGCTCCCCGCTGTCACTGCCAGTCAC           CCACAGGAAGGGACTGGTGATGGGCTGTCTCTACCCGGAGCGTGCGGGATTCAGCACCAGGCTCTTCC           CAGTACCCCAGACCCACTGTGGGTCTTCCCGTGGGATGCGGGATCCTGAGACCGAAGGGTGTTTGGTT           TAAAAAGAAGACTGGGCGTCCGCTCTTCCAGGACGGCCTCTGTGCTGCTGGGGTCACGCGAGGCTGTT           TGCAGGGGACACGGTCACAGGAGCTCTTCTGCCCTGAACGCTCCCAACCTGCCTCCCGCCCGGAAGCC           ACAGGACCCACTCATGTGTGTGCCCACAAGTGTAGTTAGCCGTCCACACCGAGGAGCCCCCGGAAGTC           CCCACTGGGCTTCAGTGTCCTCTGCCACATTCCCTGGGAGGAACAATGTCCCTCGGCTGTTCCGGTGA           AAAGTTGAGCCACCTTTGGAAGACGCACGGGTGGAGTTTGCCAGAAGAAAGGCTGTGCCAGGGCCGTG           TTTGGCTACAGGGGCTGCCGGGGCTCTTGGCTCTGCAGCGAGAAAGACACAGCCCAGCAGGGCTGGAG           ACGCCCATGTCCAGCAGGCGCAGGCCTGGCAACACGGTCCCCAGAGTCCTGAGCAGCAGTTAGGTGCA           TGGAGAGGGTATCACCTGGTGGCCACAGTCCCCCTTCTCACCTCAGCAATGATCCCCAAAGTGAGAGC           TGGCTCCCCCGGCCCCCACCACCCTCAGCAGCCCCACCCCACTCAACCCTGAGGGTCCCCAGGGTCCT           GATGAAGACCTCCGACCCCAGCGCCAGGCTCCTCGGAGCCCAACAGTCCCAAGGGGGCAGGAGACGGG           GTGGTCCAGTGCTGAGGGGTACAGCCCTGGGCCCTGACCAGCCCCGGCACCTGCCATGCTGGTTCCCC           GAATGAATCAGCTGCTGACTGTCTCCAGAAGGGCTGGAAAGGATGCTGCCAGGTGACCCGAGGTGCAC           TCGCCCCAGGGAGATGGAGTAGACAGCCTGGCCTGGCCCTCGGGACACATTGTCTGCCCCGGGGCTAT           GGGCAAATGCCCCTCCTTCTTACTTCCCAGAATCCCCTGACATTCCCAGGGTCAGCCAGGACCTGTTA           AAGCCCTGGTCACTTGGAACTGACAGCTGTGTGAGGCCTGCACTTCTCAGACCCAGACTTAGAACAAA           AGGAGGAGTGAGGACTCAAGGCTACAATGAGGTTCCAGTACTTGTTACAAGAAATTGGTTTTCTGCAA           AAGATGTGTGGTGTTTATAAAAGAACAGTTGTCATCACCGGGCATTGATTGGCAGGGACAAGGAGCTG           CTTGGGTGTGGAAAGTTGGGGCGTTGGAAAGTGGGCTGTGGTGCCCATTTGCAGTGACTGTGAAGTGA           CTCCAGGACGGACCTGCGGGGGCACCCAGAGGTCCTAAGCCCCAGGACTGAGGGTCGTGCATCACCAC           TCGGGTGTCCCGGGAGGTGCCCTGGGCCCGGGGACCTCACAGGCAGGACGGCGACACTAATGCAGGGA           GAGGGAGTCTGGCCCCAGCTTTTCCTATCAGAGGCGATTTTCCTTCACCAGGGGATGGGCAGGAAAGA           GGCAGGGGCCCCAGAAGCTTCTGTCCCTCATGCCTGAGGGCACGGGGGACACTTGGAGGCTGCTGTCA           CCACTGTGCGTCCAAGGCCATGCTCTCTGCGGGTCAGTGCCTGAGTCTCGCCTCCCTGCTGGTCCCTG           AAGCCCCCTCAGAAGCCCTGCCTGTCACGTCGGCATTTGTGAGACCTACCCTGTAACGCCTGCCCCTC           TCAGCCCAACATCAGCTTCCTCTTTCTCCCTTGCTGTAGACAGGCTGGATTCCAGTGTTGGGACAGCC           ATCTCCAGAAACCTGACTTAAGAGAGTAAGATGCAAATCGTGCCTGTATCCAGTGGCTTTGGTGGGTC           CAGGGAGTCTTGGGCACAGCCAGCTCAGCTGTCTGTGGTATGAGCAGGAACAGGTGCCACTCCTGCTC           AGGGGACCCTGCCCTACACCAGGCTGTTCCGTCCCCCTGGAGGACATGGGGCCAGGTCTGGAGGCATT           TTGGGTTGTCACAGCTGGGGGCTGTTCCTCGGCTTCAGCGGGTGGAAGCCTCAGATGCTGTTCAACAT           CTTCTGGACACGGGAGGCCCCGACAGAGAGAAGCGTCCACCCGCAAGTCCACAGTCTGAGGTCTCCCC           TCAGAGACCCTGCCCTGCACACCCACCTCCAGCCAAAGGTCCTGCCTGCCCCAGGGCTCAGGGGAACC           TTGCCGGTCTGTGGAACAGGAGAGGGGACTCTCGCCAGCTGCACCACCCTGCACGTAGTAGGTGTGCG           GTAAACATCCACCAGGGAGGCTCCAGTCAAGGCTGGCAGATGGGGCGGTCCATCCCTAGGGCAGGTGA           CAGAAGGGAAAAGGCTGCCTGCTGGCCCCCGAGCCAGGTAGCACATGCTTGTGCCTCAGTTTCCCCTC           CTGTAAAGTGAGGCGCTGGATCCAGGTTCTGTCTACTGGGCTCTGCAGCTTGGACGCTCCTAAGACCA           AGCGACCCACCCTGGGGAGGGCAGCTATGGCTTTGGAATAGCTGTCCAGGCCCGGGTGCCTCCAAGAC           GGCCACCACACCCTGCCTGTGCTGCAGGGGTGCAGGGGTAAGGGGCAAGACTCCAGAGGCCTCCTCTC           TGCATCTCCTTGTCTTCAGTGGCCGGAGGTGAGGCCTGAGCTCAGGGGAGGGGCTTCTGCCACGAACC           CTATGGCGGGGCACAGCACACTTTTCCCAGGGAGGACCCCTGGGCCCCCTGCATTATCCCCAGCGGAC           TGTGGGGTCACCTTCCAAGAGCGACATTGAGAAGCTCCAGCTCTAGGAGTGTGCAGACTCTTAACCAG           GCAGGCCCAGGCCCTGGGGCACACAAAGGCGGGGCCTGCTCTCCCCAGCTGCCCCTGCCAATGGGGGC           TGGACTGTCCTACCCTCCTCCCTTCTACCTCCCCACTGTCTTCCCTCTCCACTGTCACCACTGCCTCC           CTCTTCCACTGTCCTCCATGCACTGCCCTCCCTCCACCTTCCCCCACCCCCACCACTCCCCATGCTGT           CCCCAGGCTCCCCCCGCTCTCCCCCCTCCCCACTGTCCCCCTCCCCATGCTGTACCCAGCTCACCCCC           CTCTCCCCTCTCCCCACTGTCCCCCCTCCCACTCCCCATGCTGTCCCCAGCTCACCCTACATGGACTT           GGCGATGTCCTTCCATGGCTCACCGGTCTGAATTTCCATGATGAGCCGGGCCTGCAGCTTTGCTCCCC           TATCCCTGCCCAGGCTGCAGCTGTCCATGCAGGGAGCGAGCTCCAGCACCTGCGGAGTCCTTCCGTGC           GGGCCTCTCCGTGCCACAGCAGCCAGGGACCTCAGGTGCCTGTGCATGACACCACCGCCCATCCTCAT           CCTGAGCCAGCCTCTCAGGATCAGGACTTGGTTTGGCGGCGTTAACCTTAGAGCCTGCAAGGGGCTTC           CTCCTGGTGGGTCTGGCCGTAGCCTGGGGAGGCCACAGCTCCAGGCCACTCCAGACCTCCCTTCCTCT           GGGCCTTCCATGTGGTGGCAACCACCGCAGCTGTAAGGGAGGGAAAATGGAGCGTTTGTTCTCGGGCT           GGGCTGGGGTCTGGGGGAAGCCATGGGCGTGAAGACTGGAGTATTATTTGATGGAGAAGCGGCCACTC           CTGGAGACCGGCGGCAAACACAGAAGCACAGCGTGGAAGGTGCTGGTGTCAGCCCACACGGGTGATGG           AGCCCCAGACACAATGCATTCCTGTTGCCCTCGCCCTCAGCCAGGCCCCACGCAGGCCAGGGAGCACT           GGCAAAGCTTGGCAACCCTCTGGGGGCCAGCCTTCATCCAGGCCGAAGGTGGTCAGTGGCCCACCATG           GCCCAGGTAGAAAACTCACGGATTAAGATTTCATGCCCGACTCCAAAGGCAAGAGACTTTATTATTTT           ATTTTTTTTGAGCCAGAGTATCGCTCTGTCACCTAGGCTGGAGTGCAATCTCTGCTCATTGCAACATC           TGCCTCCCGAACTCAAGCAATTCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGTGCGCCACCA           TGCCCAGGTAATTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGGTTTCAAACTCC           TGACCTCAAATGATCTGCCCACCTCGACCTCCCAAAGTGCTGGGATTACAGGTGCGAGCCACCGCACC           TGGCTACCAGACACTTCAGAGTTACAGGTTAGTTTTTCTTTTTCTTTTATTTTTTTTTTTTTGGCGGA           GGTGCAGGGGGAGTTAAACAAACAAACAAAATAAACAGGCCGGGTGCGGTGGCTCATGCCTGTAATCC           CAGCACTTTAGGAGGCCTAGGTGGGTGGATCACGAGATCAGGGGTTCAAGACCAGCCTGGCCGAGATG           GTAAAACCCCGTCTCCACTAAAAATACAAAAATTGGCCAGGCACGGTGGCTCACACCTGTAATCCCAG           TACTTTGGGAGGCTGAGGTGGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAACCTGACCAACATGG           AGAAACCCCATCTCTACTAAAAATACAkAATTAGCCAGGTGTGGTGGTGCATGCCTGTAATTCCAGCT           GCCATTGCACTCCAGCCTGGGAACAAGAGCGAAACTCTGACTAAAAAAGAAAGAAAGAAAGAAAAAAA           TTAGTTGGGCACGGTGGCAGGCGCCTGTAATCCCAGGTACTCAGGAGGCTGAGGCAGGAGAATTGCTT           GAACCCGGGAGGCAGAGGTCGCAGTGAGCCGAGATTGCACCACTGCCCTCCAGCCTGGGTGACAGAGC           AAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAATTGGATACATTGTAATACCTCAAATACTTGTAAGT           GAAGCACCCCAGTTCCCATAGAGCTGCCGCACTCAGAGGCTTCTGTAACCTGCCTGCTCCCAGCATTC           TATTTAGGGTCTGGTATGTCCAGAATTTGCAGACACAGCAATTCCTGCAGCAGCAGTGCACCATGTGC           AAGGGGCCCCATGACCAGCCCACTGTGAGCTCACACGTGATGACTGAGGCTTCTTCACACAGCAGGGC           TCTGGGTGTGATACCCAGGGCACACGCGTTTGCACAGGCACAGGCCACACAAGTTCTCACATGCTCAG           CCCCATAAGCCGTGCTGGACAGGCATGGCCATTTACACCCAGGATCCTGCTGAGAACAGCAACCAACT           CACCACCCTCGCATCATGATCCTTGCCACACAGGGGCTCTGGTGGCTTTGGTGGCCTGGGCTGTGGCT           CTGCTGCCAGCCACCTTGAGTGAAGATCCGGGTTCTCTGGGTGCTACTCAGCTGCTATGTGGGGAGCT           CTGTCTGCATACAGACTTCTCAGGGGAGTTCTCAGCTTGGACCCTTATCTCCCCAGAATCCTGGAACC           TGCTCCTTCTGCTCTCGTGACTGACTGTGTTCTCTATGCAACTTCCAATAAAACCTCTTCATTTGAAA           GGAAAAAAGTCTGCATTATCTGTTTAGGAAGGGAGAGAGTTCATATTGCAATCTTTTTTTTTTTAATT           AAAATAATCTCAGCCTGGGCAACATGGTGAGACCCCATCTCTGTAAAACATTTTTAAAAAATTAGCCG           GGTATGGTGGCGCACACTTGTAGTCCCAGCTACTCAGGAGGCTGAAGCGGGAGGATCCATTGAACCTG           AGAAGTCGAAGCTGCAGTGAGCTGTGATTGTGCCACTGTACTCCAGCCTGGACAACAGAGTGAGACGC           CGTCTCAAATAAATAAATACAT                                           NOV31a, CG55790-02                       Protein Sequence   SEQ ID NO: 770   1473 aa   MW at 51924.6kD                     MRLGSPGLLFLLFSSLEADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIP           NSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVTLSVEVTLHVAA       NFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNNRGLYDVVSVLR       IARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVA       TGWVCRDRCLQHSYAGAWAVSPETELTGEFAVGSSRFWGAQGRLGCQLSFRVSKNFQKAKVPCLEQLL       FLETQRSPRWCAWHFLQPPLGMGWHPGVHFVTLRWDFPNMHRSRETSARPPRSPVPSPDQGVQGGSRH       RRPAPMGCPEWVQAPAPSPRGVSPAGPGTGAQPLWGVRSGSGHRQLLSVAATPAALVCPSVPGAT                                     NOV31b, 258668431   SEQ ID NO: 771   1393 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAGATCTCTTCGAGCTGATACTCAGGAGAAGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGC           TCAGCTGCGCTTGCCCTGAAGGAAGCCGTTTTGATTTAAATGATGTTTACGTATATTGGCAAACCAGT       GAGTCGAAAACCGTGGTGACCTACCACATCCCACAGAACAGCTCCTTGGAAAACGTGGACAGCCGCTA       CCGGAACCGAGCCCTGATGTCACCGGCCGGCATGCTGCGGGGCGACTTCTCCCTGCGCTTGTTCAACG       TCACCCCCCAGGACGAGCAGAAGTTTCACTGCCTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTT       TTGAGCATTGAGGTTACACTGCATGTGGCAGCAAACTTCAGCGTGCCCGTCGTCAGCGCCCCCCACAG       CCCCTCCCAGGATGAGCTCACCTTCACGTGTACATCCATAAACGGCTACCCCAGGCCCAACGTGTACT       GGATCAATAAGACGGACAACAGCCTGCTGGACCAGGCTCTGCAGAATGACACCGTCTTCTTGAACATG       CGGGGCTTGTATGACGTGGTCAGCGTGCTGAGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTG       CATAGAGAACGTGCTTCTGCAGCAGAACCTGACTGTCGGCAGCCAGACAGGAAATGACATCGGAGAGA       GAGACAAGATCACAGAGAATCCAGTCAGTACCGGCGAGAAAAACGCGGCCACGTGGAGCATCCTGGCT       GTCCTGTGCCTGCTTGTGGTCGTGGCGGTGGCCATAGGCTGGGTGTGCAGGGACCGATGCCTCCAACA       CAGCTATGCAGGTGCCTGGGCTGTGAGTCCGGAGACAGAGCTCACTGGTGAGTTTGCCGTGGGAAGCA       GCAGGTTCTGGGGGGCCCAGGGGAGGCTTGGCTGCCAGCTGTCTTTCAGAGTTTCAAAAAACTTTCAA       AAGGCAAAAGTCCCTTGCCTTGAACAACTGTTGTTCCTGGAGACGCAGCGAAGCCCTCGATGGTGCGC       ATGGCATTTCCTGCAGCCTCCCCTTGGCATGGGATGGCATCCTGGTGTGCACTTTGTCACACTGCGAT       GGGATTTTCCCAACATGCACAGAAGCAGAGAGACGAGTGCTAGACCCCCGCGCTCCCCAGTGCCCAGC       CCCAACCAGGGTGTCCAGGGCGGGTCCAGGCACCGGCGCCCAGCCCCCATGGGGTGTCCGGAGTGGGT       CCAGGCACCGGCGCCCAGCCCCCGTGGGGTGTCCAGGGCGGGTCCAGGCACCGGCGCCCAGCCCCTGT       GGGGTGTCCGGAGCGGGTCCGGGCACCGCCAGCTTCTCTCTGTGGCAGCCACTCCTGCAGCTCTCGTT       TGCCCCTCAGTTCCAGGAGCAACACTCGAGGGC                                         NOV31b, 258668431                       Protein Sequence   SEQ ID NO: 772   464 aa   MW at 50961.4kD                     TRSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRY           RNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSIEVTLHVAANFSVPVVSAPHS       PSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNNRGLYDVVSVLRIARTPSVNIGCC       IENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEIGAATWSILAVLCLLVVVAVAIGIWCRDRCLQH       SYAGAWAVSPETELTGEFAVGSSRFWGAQGRLGCQLSFRVSKNFQKAKVPCLEQLLFLETQRSPRWCA       WHFLQPPLGMGWHPGVHFVTLRWDFPNMHRSRETSARPPRSPVPSPNQGVQGGSRHRRPAPMGCPEWV       QAPAPSPRGVSRAGPGTGAQPLWGVRSGSGHRQLLSVAATPAALVCPSVPGATLEG                                     NOV31c, 309303509   SEQ ID NO: 773   1393 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                     CACCAGATCTCTTCGAGCTGATACTCAGGAGAAGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGC           TCAGCTGCGCTTGCCCTGAAGGAAGCCGTTTTGATTTAAATGATGTTTACGTATATTGGCAAACCAGT       GAGTCGAAAACCGTGGTGACCTACCACATCCCACAGAACAGCTCCTTGGAAAACGTGGACAGCCGCTA       CCGGAACCGAGCCCTGATGTCACCGGCCGGCATGCTGCGGGGCGACTTCTCCCTGCGCTTGTTCAACG       TCACCCCCCAGGACGAGCAGAAGTTTCACTGCCTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTT       TTGAGCATTGAGGTTACACTGCATGTGGCAGCAAACTTCAGCGTGCCCGTCGTCAGCGCCCCCCACAG       CCCCTCCCAGGATGAGCTCACCTTCACGTGTACATCCATAAACGGCTACCCCAGGCCCAACGTGTACT       GGATCAATAAGACGGACAACAGCCTGCTGGACCAGGCTCTGCAGAATGACACCGTCTTCTTGAACATG       CGGGGCTTGTATGACGTGGTCAGCGTGCTGAGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTG       CATAGAGAACGTGCTTCTGCAGCAGAACCTGACTGTCGGCAGCCAGACAGGAAATGACATCGGAGAGA       GAGACAAGATCACAGAGAATCCAGTCAGTACCGGCGAGAAAAACGCGGCCACGTGGAGCATCCTGGCT       GTCCTGTGCCTGCTTGTGGTCGTGGCGGTGGCCATAGGCTGGGTGTGCAGGGACCGATGCCTCCAACA       CAGCTATGCAGGTGCCTGGGCTGTGAGTCCGGAGACAGAGCTCACTGGTGAGTTTGCCGTGGGAAGCA       GCAGGTTCTGGGGGGCCCAGGGGAGGCTTGGCTGCCAGCTGTCTTTCAGAGTTTCAAAAAACTTTCAA       AAGGCAAAAGTCCCTTGCCTTGAACAACTGTTGTTCCTGGAGACGCAGCGAAGCCCTCGATGGTGCGC       ATGGCATTTCCTGCAGCCTCCCCTTGGCATGGGATGGCATCCTGGTGTGCACTTTGTCACACTGCGAT       GGGATTTTCCCAACATGCACAGAAGCAGAGAGACGAGTGCTAGACCCCCGCGCTCCCCAGTGCCCAGC       CCCGACCAGGGTGTCCAGGGCGGGTCCAGGCACCGGCGCCCAGCCCCCATGGGGTGTCCGGAGTGGGT       CCAGGCACCGGCGCCCAGCCCCCGTGGGGTGTCCAGGGCGGGTCCAGGCACCGGCGCCCAGCCCCTGT       GGGGTGTCCGGAGCGGGTCCGGGCACCGCCAGCTTCTCTCTGTGGCAGCCACTCCTGCAGCTCTCGTT       TGCCCCTCAGTTCCAGGAGCAACACTCGAGGGC                                         NOV31c, 309303509                       Protein Sequence   SEQ ID NO: 774   464 aa   MW at 50962.4kD                     TRSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRY           RNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSIEVTLHVAANFSVPVVSAPHS       PSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCC       IENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKAAATWSILAVLCLLVVVAVAIGWVCRDRCLQH       SYAGAWAVSPETELTGEFAVGSSRFWGAQGRLGCQLSFRVSKNFQKAKVPCLEQLLFLETQRSPRWCA       WHFLQPPLGMGWHPGVHFVTLRWDFPNMHRSRETSARPPRSPVPSPDQGVQGGSRHRRPAPMGCPEWV       QAPAPSPRGVSRAGPGTGAQPLWGVRSGSGHRQLLSVAATPAALVCPSVPGATLEG                                     NOV31d, 315925314   SEQ ID NO: 775   871 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCGATACTCAGGAGAAGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGCTCAGCTGCG           CTTGCCCTGAAGGAAGCCGTTTTGATTTAAATGATGTTTACGTATATTGGCAAACCAGTGAGTCGAAA       ACCGTGGTGACCTACCACATCCCACAGAACAGCTCCTTGGAAAACGTGGACAGCCGCTACCGGAACCG       AGCCCTGATGTCACCGGCCGGCATGCTGCGGGGCGACTTCTCCCTGCGCTTGTTCAACGTCACCCCCC       AGGACGAGCAGAAGTTTCACTGCCTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTTTTGAGCGTT       GAGGTTACACTGCATGTGGCGGCAAACTTCAGCGTGCCCGTCGTCAGCGCCCCCCACAGCCCCTCCCA       GGATGAGCTCACCTTCACGTGTACATCCATAAACGGCTACCCCAGGCCCAACGTGTACTGGATCAATA       AGACGGACAACAGCCTGCTGGACCAGGCTCTGCAGAATGACACCGTCTTCTTGAACATGCGGGGCTTG       TATGACGTGGTCAGCGTGCTGAGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTGCATAGAGAA       CGTGCTTCTGCAGCAGAACCTGACTGTCGGCAGCCAGACAGGAAATGACATCGGAGAGAGAGACAAGA       TCACAGAGAATCCAGTCAGTACCGGCGAGAAAAACGCGGCCACGTGGAGCATCCTGGCTGTCCTGTGC       CTGCTTGTGGTCGTGGCGGTGGCCATAGGCTGGGTGTGCAGGGACCGATGCCTCCAACACAGCTATGC       AGGTGCCTGGGCTGTGAGTCCGGAGACAGAGCTCACTGGTCACCTGCTCGAGGGC                                         NOV31d, 315925314                       Protein Sequence   SEQ ID NO: 776   290 aa   MW at 31946.7kD                     TGSDTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNR           ALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQ       DELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIEN       VLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYA       GAWAVSPETELTGHLLEG                                     NOV31e, 315970230   SEQ ID NO: 777   928 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCACCATGCGGCTGGGCAGTCCTGGACTGCTCTTCCTGCTCTTCAGCAGCCTTCGAGCTG           ATACTCAGGAGAAGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGCTCAGCTGCGCTTGCCCTGAA       GGAAGCCGTTTTGATTTAAATGATGTTTACGTATATTGGCAAACCAGTGAGTCGAAAACCGTGGTGAC       CTACCACATCCCACAGAACAGCTCCTTGGAAAACGTGGACAGCCGCTACCGGAACCGAGCCCTGATGT       CACCGGCCGGCATGCTGCGGGGCGACTTCTCCCTGCGCTTGTTCAACGTCACCCCCCAGGACGAGCAG       AAGTTTCACTGCCTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTTTTGAGCGTTGAGGTTACACT       GCATGTGGCGGCAAACTTCAGCGTGCCCGTCGTCAGCGCCCCCCACAGCCCCTCCCAGGATGAGCTCA       CCTTCACGTGTACATCCATAAACGGCTACCCCAGGCCCAACGTGTACCGGATCAATAAGACGGACAAC       AGCCTGCTGGACCAGGCTCTGCAGAATGACACCGTCTTCTTGAACATGCGGGGCTTGTATGACGTGGT       CAGCGTGCTGAGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTGCATAGAGAACGTGCTTCTGC       AGCAGAACCTGACTGTCGGCAGCCAGACAGGAAATGACATCGGAGAGAGAGACAAGATCACAGAGAAT       CCAGTCAGTACCGGCGAGAAAAACGCGGCCACGTGGAGCATCCTGGCTGTCCTGTGCCTGCTTGTGGT       CGTGGCGGTGGCCATAGGCTGGGTGTGCAGGGACCGATGCCTCCAACACAGCTATGCAGGTGCCTGGG       CTGTGAGTCCGGAGACAGAGCTCACTGGTCACCTGCTCGAGGGC                                         NOV31e, 315970230                       Protein Sequence   SEQ ID NO: 778   309 aa   MW at 33978.1kD                     TGSTMRLGSPGLLFLLFSSLEADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVT           YHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTL       HVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYRINKTDNSLLDQALQNDTVFLNMRGLYDVV       SVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVV       VAVAIGWVCRDRCLQHSYAGAWAVSPETELTGHLLEG                                     NOV31f, CG55790-01   SEQ ID NO: 779   912 bp           DNA Sequence   ORF Start: ATG at 4   ORF Stop: TAA at 910                       ACC   ATG CGGCTGGGCAGTCCTGGACTGCTCTTCCTGCTCTTCAGCAGCCTTCGAGCTGATACTCAGGA           GAAGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGCTCAGCTGCGCTTGCCCTGAAGGAAGCCGTT       TTGATTTAAATGATGTTTACGTATATTGGCAAACCAGTGAGTCGAAAACCGTGGTGACCTACCACATC       CCACAGAACAGCTCCTTGGAAAACGTGGACAGCCGCTACCGGAACCGAGCCCTGATGTCACCGGCCGG       CATGCTGCGGGGCGACTTCTCCCTGCGCTTGTTCAACGTCACCCCCCAGGACGAGCAGAAGTTTCACT       GCCTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTTTTGAGCGTTGAGGTTACACTGCATGTGGCA       GCAAACTTCAGCGTGCCCGTCGTCAGCGCCCCCCACAGCCCCTCCCAGGATGAGCTCACCTTCACGTG       TACATCCATAAACGGCTACCCCAGGCCCAACGTGTACTGGATCAATAAGACGGACAACAGCCTGCTGG       ACCAGGCTCTGCAGAATGACACCGTCTTCTTGAACATGCGGGGCTTGTATGACGTGGTCAGCGTGCTG       AGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTGCATAGAGAACGTGCTTCTGCAGCAGAACCT       GACTGTCGGCAGCCAGACAGGAAATGACATCGGAGAGAGAGACAAGATCACAGAGAATCCAGTCAGTA       CCGGCGAGAAAAACGCGGCCACGTGGAGCATCCTGGCTGTCCTGTGCCTGCTTGTGGTCGTGGCGGTG       GCCATAGGCTGGGTGTGCAGGGACCGATGCCTCCAACACAGCTATGCAGGTGCCTGGGCTGTGAGTCC       GGAGACAGAGCTCACTGGTCACCTG TAA                                           NOV31f, CG55790-01                       Protein Sequence   SEQ ID NO: 780   302 aa   MW at 33362.5kD                     MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIP           QNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAA       NFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNNRGLYDVVSVLR       IARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVA       IGWVCPDRCLQHSYAGAWAVSPETELTGHL                                     NOV31g, 0G55790-03   SEQ ID NO: 781   910 bp           DNA Sequence   ORF Start: ATG at 2   ORF Stop: TAA at 908                       C   ATG CGGCTGGGCAGTCCTGGACTGCTCTTCCTGCTCTTCAGCAGCCTTCGAGCTGATACTCAGGAGA           AGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGCTCAGCTGCGCTTGCCCTGAAGGAAGCCGTTTT       GATTTAAATGATGTTTACGTATATTGGCAAACCAGTGAGTCGAAAACCGTGGTGACCTACCATATCCC       ACAGAACAGCTCCTTGGAAAACGTGGACAGCCGCTACCGGAACCGAGCCCTGATGTCACCGGCCGGCA       TGCTGCGGGGCGACTTCTCCCTGCGCTTGTTCAACGTCACCCCCCAGGACGAGCAGAAGTTTCACTGC       CTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTTTTGAGCGTTGAGGTTACACTGCATGTGGCAGC       AAACTTCAGCGTGCCCGTCGTCAGCGCCCCCCACAGCCCCTCCCAGGATGAGCTCACCTTCACGTGTA       CATCCATAAACGGCTACCCCAGGCCCAACGTGTACTGGATCAATAAGACGGACAACAGCCTGCTGGAC       CAGGCTCTGCAGAATGACACCGTCTTCTTGAACATGCGGGGCTTGTATGACGTGGTCAGCGTGCTGAG       GATCGCACGGACCCCCAGCGTGAACATTGGCTGCTGCATAGAGAACGTGCTTCTGCAGCAGAACCTGA       GGCGAGAAAAACGCGGCCACGTGGAGCATCCTGGCTGTCCTGTGCCTGCTTGTGGTCGTGGCGGTGGC       CATAGGCTGGGTGTGCAGGGACCGATGCCTCCAACACAGCTATGCAGGTGCCTGGGCTGTGAGTCCGG       AGACAGAGCTCACTGGTCACCTG TAA                                           NOV31g, CG55790-03                       Protein Sequence   SEQ ID NO: 782   302 aa   MW at 33362.5kD                     MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIP           QNSSLENVDSRYRNEALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAA       NFSVPWSAPHSPSQDELTFTCTSINGYPRPNVYVVINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLR       IARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVA       IGWVCRDRCLQHSYAGAWAVSPETELTGHL                                     NOV31h, CG55790-04   SEQ ID NO: 783   705 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GATACTCAGGAGAAGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGCTCAGCTGCGCTTGCCCTGA           AGGAAGCCGTTTTGATTTAAATGATGTTTACGTATATTGGCAAACCAGTGAGTCGAAAACCGTGGTGA       CCTACCACATCCCACAGAACAGCTCCTTGGAAAACGTGGACAGCCGCTACCGGAACCGAGCCCTGATG       TCACCGGCCGGCATGCTGCGGGGCGACTTCTCCCTGCGCTTGTTCAACGTCACCCCCCAGGACGAGCA       GAAGTTTCACTGCCTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTTTTGAGCGTTGAGGTTACAC       TGCATGTGGCAGCAAACTTCAGCGTGCCCGTCGTCAGCGCCCCCCACAGCCCCTCCCAGGATGAGCTC       ACCTTCACGTGTACATCCATAAACGGCTACCCCAGGCCCAACGTGTACTGGATCAATAAGACGGACAA       CAGCCTGCTGGACCAGGCTCTGCAGAATGACACCGTCTTCTTGAACATGCGGGGCTTGTATGACGTGG       TCAGCGTGCTGAGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTGCATAGAGAACGTGCTTCTG       CAGCAGAACCTGACTGTCGGCAGCCAGACAGGAAATGACATCGGAGAGAGAGACAAGATCACAGAGAA       TCCAGTCAGTACCGGCGAGAAAAAC                                         NOV31h, CG55790-04                       Protein Sequence   SEQ ID NO: 784   235 aa   MW at 26169.1kD                     DTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALM           SPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDEL       TFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLL       QQNLTVGSQTGNDIGERDKITENPVSTGEKN                                     NOV31i, CG55790-05   SEQ ID NO: 785   393 bp           DNA Sequence   ORF Start: at 11   ORF Stop: at 1385                       CACCAGATCT CTTCGAGCTGATACTCAGGAGAAGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGC           TCAGCTGCGCTTGCCCTGAAGGAAGCCGTTTTGATTTAAATGATGTTTACGTATATTGGCAAACCAGT       GAGTCGAAAACCGTGGTGACCTACCACATCCCACAGAACAGCTCCTTGGAAAACGTGGACAGCCGCTA       CCGGAACCGAGCCCTGATGTCACCGGCCGGCATGCTGCGGGGCGACTTCTCCCTGCGCTTGTTCAACG       TCACCCCCCAGGACGAGCAGAAGTTTCACTGCCTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTT       TTGAGCATTGAGGTTACACTGCATGTGGCAGCAAACTTCAGCGTGCCCGTCGTCAGCGCCCCCCACAG       CCCCTCCCAGGATGAGCTCACCTTCACGTGTACATCCATAAACGGCTACCCCAGGCCCAACGTGTACT       GGATCAATAAGACGGACAACAGCCTGCTGGACCAGGCTCTGCAGAATGACACCGTCTTCTTGAACATG       CGGGGCTTGTATGACGTGGTCAGCGTGCTGAGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTG       CATAGAGAACGTGCTTCTGCAGCAGAACCTGACTGTCGGCAGCCAGACAGGAAATGACATCGGAGAGA       GAGACAAGATCACAGAGAATCCAGTCAGTACCGGCGAGAAAAACGCGGCCACGTGGAGCATCCTGGCT       GTCCTGTGCCTGCTTGTGGTCGTGGCGGTGGCCATAGGCTGGGTGTGCAGGGACCGATGCCTCCAACA       CAGCTATGCAGGTGCCTGGGCTGTGAGTCCGGAGACAGAGCTCACTGGTGAGTTTGCCGTGGGAAGCA       GCAGGTTCTGGGGGGCCCAGGGGAGGCTTGGCTGCCAGCTGTCTTTCAGAGTTTCAAAAAACTTTCAA       AAGGCAAAAGTCCCTTGCCTTGAACAACTGTTGTTCCTGGAGACGCAGCGAAGCCCTCGATGGTGCGC       ATGGCATTTCCTGCAGCCTCCCCTTGGCATGGGATGGCATCCTGGTGTGCACTTTGTCACACTGCGAT       GGGATTTTCCCAACATGCACAGAAGCAGAGAGACGAGTGCTAGACCCCCGCGCTCCCCAGTGCCCAGC       CCCAACCAGGGTGTCCAGGGCGGGTCCAGGCACCGGCGCCCAGCCCCCATGGGGTGTCCGGAGTGGGT       CCAGGCACCGGCGCCCAGCCCCCGTGGGGTGTCCAGGGCGGGTCCAGGCACCGGCGCCCAGCCCCTGT       GGGGTGTCCGGAGCGGGTCCGGGCACCGCCAGCTTCTCTCTGTGGCAGCCACTCCTGCAGCTCTCGTT       TGCCCCTCAGTTCCAGGAGCAACACTC GAGGGC                                           NOV31i, CG55790-05                       Protein Sequence   SEQ ID NO: 786   458 aa   MW at 50317.7kD                     LRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNR           ALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSIEVTLHVAANFSVPVVSAPHSPSQ       DELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIEN       VLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSITAVLCLLVVVAVAIGWVCRDRCLQHSYA       GAWAVSPETELTGEFAVGSSRFWGAQGRLGCQLSFRVSKNFQKAKVPCLEQLLFLETQRSPRWCAWHF       LQPPLGMGWHPGVHFVTLRWDFPNNHRSRETSARPPRSPVPSPNQGVQGGSRHRRPAPMGCPEWVQAP       APSPRGVSRAGPGTGAQPLWGVRSGSGHRQLLSVAATPAALVCPSVPGAT                                     NOV31j, CG55790-06   SEQ ID NO: 787   928 bp           DNA Sequence   ORF Start: ATG at 14   ORF Stop: at 920                       CACCGGATCCACC   ATG CGGCTGGGCAGTCCTGGACTGCTCTTCCTGCTCTTCAGCAGCCTTCGAGCTG           ATACTCAGGAGAAGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGCTCAGCTGCGCTTGCCCTGAA       GGAAGCCGTTTTGATTTAAATGATGTTTACGTATATTGGCAAACCAGTGAGTCGAAAACCGTGGTGAC       CTACCACATCCCACAGAACAGCTCCTTGGAAAACGTGGACAGCCGCTACCGGAACCGAGCCCTGATGT       AAGTTTCACTGCCTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTTTTGAGCATTGAGGTTACACT       CCTTCACGTGTACATCCATAAACGGCTACCCCAGGCCCAACGTGTACTGGATCAATAAGACGGACAAC       CACGTGCTGAGGAATCGCACGGACCCCCAGCGTGAACATTGGCTGCTGCATAGAGAACGTGCTTCTGC       AGCAGAACCTGACTGTCGGCAGCCAGACAGGAAATGACATCGGAGAGAGAGACAAGATCACAGAGAAT       CCAGTCAGTACCGGCGAGAAAAACGCGGCCACGTGGAGCATCCTGGCTGTCCTGTGCCTGCTTGTGGT       CGTGGCGGTGGCCATAGGCTGGGTGTGCAGGGACCGATGCCTCCAACACAGCTATGCAGGTGCCTGGG       CTGTGAGTCCGGAGACAGAGCTCACTGGTCACCTGCTC GAGGGC                                           NOV31j, CG55790-06                       Protein Sequence   SEQ ID NO: 788   1302 aa   MW at 33376.5kD                     MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIP           QNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSIEVTLHVAA       NFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLR       IARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVA       IGWVCRDRCLQHSYAGAWAVSPETELTGHL                                     NOV31k, CG55790-07   SEQ ID NO: 789   871 bp           DNA Sequence   ORF Start: at 11   ORF Stop: at 863                       CACCGGATCC GATACTCAGGAGAAGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGCTCAGCTGCG           CTTGCCCTGAAGGAAGCCGTTTTGATTTAAATGATGTTTACGTATATTGGCAAACCAGTGAGTCGAAA       ACCGTGGTGACCTACCACATCCCACAGAACAGCTCCTTGGAAAACGTGGACAGCCGCTACCGGAACCG       AGCCCTGATGTCACCGGCCGGCATGCTGCGGGGCGACTTCTCCCTGCGCTTGTTCAACGTCACCCCCC       AGGACGAGCAGAAGTTTCACTGCCTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTTTTGAGCGTT       GAGGTTACACTGCATGTGGCGGCAAACTTCAGCGTGCCCGTCGTCAGCGCCCCCCACAGCCCCTCCCA       GGATGAGCTCACCTTCACGTGTACATCCATAAACGGCTACCCCAGGCCCAACGTGTACTGGATCAATA       AGACGGACAACAGCCTGCTGGACCAGGCTCTGCAGAATGACACCGTCTTCTTGAACATGCGGGGCTTG       TATGACGTGGTCAGCGTGCTGAGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTGCATAGAGAA       CGTGCTTCTGCAGCAGAACCTGACTGTCGGCAGCCAGACAGGAAATGACATCGGAGAGAGAGACAAGA       TCACAGAGAATCCAGTCAGTACCGGCGAGAAAAACGCGGCCACGTGGAGCATCCTGGCTGTCCTGTGC       CTGCTTGTGGTCGTGGCGGTGGCCATAGGCTGGGTGTGCAGGGACCGATGCCTCCAACACAGCTATGC       AGGTGCCTGGGCTGTGAGTCCGGAGACAGAGCTCACTGGTCACCTGCTC GAGGGC                                           NOV31k, CG55790-07                       Protein Sequence   SEQ ID NO: 790   284 aa   MW at 31402.1kD                     DTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNPALM           SPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDEL       TFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLL       AVSPETELTGHL                                     NOV31l,                   SNP1 3374852 of   SEQ ID NO: 791   912 bp       CG55790-01,   ORF Start: ATG at 4   ORF Stop: TAA at 910       DNA Sequence   SNP Pos: 296   SNP Change: T to C                       ACC   ATG CGGCTGGGCAGTCCTGGACTGCTCTTCCTGCTCTTCAGCAGCCTTCGAGCTGATACTCAGGA           GAAGGAAGTCAGAGCGATGGTAGGCAGCGACGTGGAGCTCAGCTGCGCTTGCCCTGAAGGAAGCCGTT       TTGATTTAAATGATGTTTACGTATATTGGCAAACCAGTGAGTCGAAAACCGTGGTGACCTACCACATC       CCACAGAACAGCTCCTTGGAAAACGTGGACAGCCGCTACCGGAACCGAGCCCTGATGTCACCGGCCGG       CATGCTGCGGGGCGACTTCTCCCAGCGCTTGTTCAACGTCACCCCCCAGGACGAGCAGAAGTTTCACT       GCCTGGTGTTGAGCCAATCCCTGGGATTCCAGGAGGTTTTGAGCGTTGAGGTTACACTGCATGTGGCA       GCAAACTTCAGCGTGCCCGTCGTCAGCGCCCCCCACAGCCCCTCCCAGGATGAGCTCACCTTCACGTG       ACCAGGCTCTGCAGAATGACACCGTCTTCTTGAACATGCGGGGCTTGTATGACGTGGTCAGCGTGCTG       AGGATCGCACGGACCCCCAGCGTGAACATTGGCTGCTGCATAGAGAACGTGCTTCTGCAGCAGAACCT       GACTGTCGGCAGCCAGACAGGAAATGACATCGGAGAGAGAGACAAGATCACAGAGAATCCAGTCAGTA       CCGGCGAGAAAAACGCGGCCACGTGGAGCATCCTGGCTGTCCTGTGCCTGCTTGTGGTCGTGGCGGTG       GCCATAGGCTGGGTGTGCAGGGACCGATGCCTCCAACACAGCTATGCAGGTGCCTGGGCTGTGAGTCC       GGAGACAGAGCTCACTGGTCACCTG TAA                                           NOV31l,                       SNP13374852 of       CG55790-01,   SEQ ID NO: 792       MW at 33346.5kD       Protein Sequence   SNP Pos: 98   302 aa   SNP Change: Leu to Pro                     MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIP           QNSSLENVDSRYRNRALMSPAGMLRGDFS   P   RLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAA       NFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNDRGLYDVVSVLR       IARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVA       IGWVCRDRCLQHSYAGAWAVSPETELTGHL                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 31B.  
                   TABLE 31B                       Comparison of the NOV31 protein sequences.                                            NOV31a   ----MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQT           NOV31b   ----------------TRSLPADTQEKEVRANVGSDVELSCACPEGSRFDLNDVYVYWQT       NOV31c   ----------------TRSLRADTQEKEVPAMVGSDVELSCACPEGSRFDLNDVYVYWQT       NOV31d   -------------------TGSDTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQT       NOV31e   TGSTMRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQT       NOV31f   ----MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQT       NOV31g   ----MRLGSPGLLFLLFSSLRADTQEKEVRANVGSDVELSCACPEGSRFDLNDVYVYWQT       NOV31h   ----------------------DTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQT       NOV31i   -------------------LRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQT       NOV31j   ----MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQT       NOV3lk   ----------------------DTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQT               NOV31a   SESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVL       NOV31b   SESKTVVTYHIPQNSSLENVDSRYPNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVL       NOV31c   SESKTVVTYHIPQNSSLENVDSRYPNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVL       NOV31d   SESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVL       NOV31e   SESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVL       NOV31f   SESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVL       NOV31g   SESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVL       NOV31h   SESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVL       NOV31i   SESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVL       NOV31j   SESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVL       NOV31k   SESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVL               NOV31a   SQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTD       NOV31b   SQSLGFQEVLSIEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTD       NOV31c   SQSLGFQEVLSIEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTD       NOV31d   SQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTD       NOV31e   SQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYRINKTD       Nov31f   SQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTD       NOV31g   SQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTD       NOV31h   SQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTD       NOV31i   SQSLGFQEVLSIEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTD       NOV31j   SQSLGFQEVLSIEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTD       NOV31k   SQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTD               NOV31a   NSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDI       NOV31b   NSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDI       NOV31c   NSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDI       NOV31d   NSLLDQALQNDTVFLNNRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDI       NOV31e   NSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDI       Nov31f   NSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDI       NOV31g   NSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDI       NOV31h   NSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDI       NOV31i   NSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDI       NOV31j   NSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDI       NOV31k   NSLLDQALQNDTVFLNNRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDI               NOV31a   GERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPET       NOV31b   GERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPET       NOV31c   GERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPET       NOV31d   GERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPET       NOV31e   GERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPET       NOV31f   GERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPET       NOV31g   GERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPET       NOV31h   GERDKITENPVSTGEKN-------------------------------------------       NOV31i   GERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPET       NOV31j   GERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPET       NOV31k   GERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPET               NOV31a   ELTGEFAVGSSRFWGAQGRLGCQLSFRVSKNFQKAKVPCLEQLLFLETQRSPRWCAWHFL       NOV31b   ELTGEFAVGSSRFWGAQGRLGCQLSFRVSKNFQKAKVPCLEQLLFLETQRSPRWCAWHFL       NOV31c   ELTGEFAVGSSRFWGAQGRLGCQLSFRVSKNFQKAKVPCLEQLLFLETQRSPRWCAWHFL       NOV31d   ELTGHLLEG---------------------------------------------------       NOV31e   ELTGHLLEG---------------------------------------------------       NOV31f   ELTGHL------------------------------------------------------       NOV31g   ELTGHL------------------------------------------------------       NOV31h   ------------------------------------------------------------       NOV31i   ELTGEFAVGSSRFWGAQGRLGCQLSFRVSKNFQKAKVPCLEQLLFLETQRSPRWCAWHFL       NOV31j   ELTGHL------------------------------------------------------       NOV31k   ELTGHL------------------------------------------------------               NOV31a   QPPLGMGWHPGVHFVTLRWDFPNMHRSRETSARPPRSPVPSPDQGVQGGSRHRRPAPMGC       NOV31b   QPPLGMGWHPGVHFVTLRWDFPNMHRSRETSARPPRSPVPSPNQGVQGGSRHRRPAPMGC       NOV31c   QPPLGMGWHPGVHFVTLRWDFPNMHRSRETSARPPRSPVPSPDQGVQGGSRHRRPAPMGC       NOV31d   ------------------------------------------------------------       NOV31e   ------------------------------------------------------------       NOV31f   ------------------------------------------------------------       NOV31g   ------------------------------------------------------------       NOV31h   ------------------------------------------------------------       NOV31i   QPPLGMGWHPGVHFVTLRWDFPNNHRSRETSARPPRSPVPSPNQGVQGGSRHRRPAPMGC       NOV31j   ------------------------------------------------------------       NOV31k   ------------------------------------------------------------               NOV31a   PEWVQAPAPSPRGVSEAGPGTGAQPLWGVRSGSGHRQLLSVAATPAALVCPSVPGAT---       NOV31b   PEWVQAPAPSPRGVSRAGPGTGAQPLWGVRSGSGHRQLLSVAATPAALVCPSVPGATLEG       NOV31c   PEWVQAPAPSPRGVSRAGPGTGAQPLWGVRSGSGHRQLLSVAATPAALVCPSVPGATLEG       NOV31d   ------------------------------------------------------------       NOV31e   ------------------------------------------------------------       NOV3lf   ------------------------------------------------------------       NOV31g   ------------------------------------------------------------       NOV31h   ------------------------------------------------------------       NOV31i   PEWVQAPAPSPRGVSPAGPGTGAQPLWGVRSGSGHRQLLSVAATPAALVCPSVPGAT---       NOV31j   ------------------------------------------------------------       NOV31k   ------------------------------------------------------------               NOV31a   (SEQ ID NO: 770)       NOV31b   (SEQ ID NO: 772)       NOV31c   (SEQ ID NO: 774)       NOV31d   (SEQ ID NO: 776)       NOV31e   (SEQ ID NO: 778)       NOV3lf   (SEQ ID NO: 780)       NOV3lg   (SEQ ID NO: 782)       NOV3lh   (SEQ ID NO: 784)       NOV31i   (SEQ ID NO: 786)       NOV31j   (SEQ ID NO: 788)       NOV31k   (SEQ ID NO: 790)                  
 
      Further analysis of the NOV31 a protein yielded the following properties shown in Table 31C.  
               TABLE 31C                       Protein Sequence Properties NOV31a                                        SignalP analysis:   Cleavage site between residues 19 and 20       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 2; pos. chg 1; neg. chg 0           H-region:   length 14; peak value 10.56           PSG score:   6.16                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 1.98           possible cleavage site: between 20 and 21                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 20)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 21           Tentative number of TMS(s) for the threshold 0.5: 2           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 258-274               −13.27                             PERIPHERAL   Likelihood = 2.97 (at 127)                         ALOM score: −13.27 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 10           Charge difference: −2.0 C(0.0)-N(2.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 1a (cytoplasmic tail 275 to 473)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   2   Hyd Moment(75):   5.99           Hyd Moment(95):   8.79   G content:   2           D/E content:   1   S/T content:   3                         Score: −2.92       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 27 LRA|DT                 NUCDISC: discrimination of nuclear localization signals                         pat4: RHRR (3) at 407           pat7: none           bipartite: none           content of basic residues: 8.9%           NLS Score: −0.29       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: RLGS                 none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: found                         LL at 339           LL at 454                 checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 76.7       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         55.6%: endoplasmic reticulum           22.2%: Golgi           11.1%: plasma membrane           11.1%: extracellular, including cell wall                 &gt;&gt; prediction for CG55790-02 is end (k = 9)                  
 
      A search of the NOV31a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 31D.  
               TABLE 31D                          Geneseq Results for NOV31a                                         NOV31a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value                                             ABG30731   Human B7-H2 transcript 2 (B7-H2 V2)   1 . . . 473   471/473   (99%)   0.0           polypeptide -  Homo sapiens , 473 aa.   1 . . . 473   473/473   (99%)           [WO200253733-A2, 11-JUL-2002]       AAU00422   Human B7-3 protein -  Homo sapiens ,   1 . . . 473   471/516   (91%)   0.0           516 aa. [WO200112658-A2, 22-FEB-   1 . . . 516   471/516   (91%)           2001]       AAU99789   Human B7 related protein-1 (B7RP1)   1 . . . 300   300/300   (100%)   e−174           #2 -  Homo sapiens , 302 aa.   1 . . . 300   300/300   (100%)           [WO200244364-A2, 06-JUN-2002]       AAG67292   Amino acid sequence of a human hB7-   1 . . . 300   300/300   (100%)   e−174           H2 polypeptide -  Homo sapiens , 302   1 . . . 300   300/300   (100%)           aa. [WO200164704-A1, 07-SEP-2001]       AAB08729   Amino acid sequence of a human   1 . . . 300   300/300   (100%)   e−174           B7RP1 polypeptide -  Homo sapiens ,   1 . . . 300   300/300   (100%)           302 aa. [WO200046240-A2, 10-AUG-           2000]                  
 
      In a BLAST search of public sequence databases, the NOV31 a protein was found to have homology to the proteins shown in the BLASTP data in Table 31E.  
               TABLE 31E                          Public BLASTP Results for NOV31a                                         NOV31a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             O75144   ICOS ligand precursor (B7 homolog 2)   1 . . . 300   300/300   (100%)    e−174           (B7-H2) (B7-like protein GI50) (B7-   1 . . . 300   300/300   (100%)           related protein-1) (B7RP-1) -  Homo               sapiens  (Human), 302 aa.       CAD57064   Sequence 11 from Patent WO0244364 -   1 . . . 288   288/288   (100%)    e−166             Mus musculus  (Mouse), 288 aa   1 . . . 288   288/288   (100%)           (fragment).       Q9JHJ8   ICOS ligand precursor (B7 homolog 2)   7 . . . 295   135/291   (46%)   2e−58           (B7-H2) (B7-like protein GI50) (B7-   32 . . . 317    172/291   (58%)           related protein-1) (B7RP-1) (LICOS) -             Mus musculus  (Mouse), 322 aa.       O42404   CD80-like protein -  Gallus gallus     2 . . . 283   99/291   (34%)   6e−33           (Chicken), 296 aa.   3 . . . 288   153/291   (52%)       Q9BXR1   Costimulatory molecule -  Homo     2 . . . 277   89/292   (30%)   3e−21             sapiens  (Human), 316 aa.   4 . . . 270   131/292   (44%)                  
 
      PFam analysis predicts that the NOV31a protein contains the domains shown in the Table 31F.  
               TABLE 31F                          Domain Analysis of NOV31a                                             Identities/                       Similarities           Pfam   NOV31a   for the   Expect           Domain   Match Region   Matched Region   Value                       ig   30 . . . 115   16/87 (18%)   0.011                   60/87 (69%)                      
 
     Example 32  
      The NOV32 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 32A.  
                   TABLE 32A                       NOV32 Sequence Analysis                                                NOV32a, CG55906-04   SEQ ID NO: 793   4119 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAG at 4117                       ATG TCTGCTCCAGACGAAGGGAGACGGGATCCCCCCAAACCGAAGGGCAAGACCCTGGGCAGCTTCTT           TGGGTCCCTGCCTGGCTTCAGCTCTGCCCGGAACCTGGTGGCCAACGCACATAGCTCGGCGAGAGCCC       GGCCGGCCGCTGACCCCACAGGAGCGCCTGCTGCCGAGGCTGCCCAACCACAGGCTCAGGTGGCTGCC       CACCCAGAGCAGACGGCCCCATGGACGGAGAAGGAGCTGCAACCTTCGGAAAAGCAGATGGTGTCCGG       GGCCAAAGACCTGGTGTGTTCCAAGATGTCCAGGGCCAAGGATGCCGTGTCCTCCGGGGTGGCCAGCG       TGGTGGACGTGGCTAAGGGAGTGGTCCAGGGAGGCCTGGACACCACTCGGTCTGCACTTACGGGCACC       GGACACCTCGAAGGCTGTCCTCACCGGCACCAAGGACACGGTGTCCACTGGGCTCACGGGGGCAGTGA       ATGTGGCCAAAGGGACCGTACAGGCCGGTGTGGACACCACCAAGACTGTGCTGACCGGCACCAAAGAC       ACAGTGACTACTGGGGTCATGGGGGCAGTGAACTTGGCCAAAGGGACTGTCCAGACTGGCGTGGAAAC       CTCCAAGGCTGTGCTGACCGGCACCAAAGATGCTGTGTCCACTGGGCTCACAGGGGCAGTGAATGTGG       CCAGAGGAAGCATTCAGACCGGTGTGGACACCAGTAAGACTGTCCTAACAGGTACCAAGGACACCGTC       TGTAGTGGGGTGACTGGTGCCATGAATGTGGCCAAAGGAACCATCCAGACCGGCGTGGACACCAGTAA       GACTGTCCTAACAGGTACCAAGGACACCGTCTGTAGTGGGGTGACTGGTGCCATGAATGTGGCCAAAG       GAACCATCCAGACCGGCGTGGACACCAGTAAGACTGTCCTAACAGGTACCAAGGACACCGTCTGTAGT       GGGGTGACTGGTGCCATGAATGTGGCCAAAGGAACCATCCAGACCGGCGTGGACACCACCAAGACTGT       CCTAACTGGCACCAAGAACACTGTCTGCAGTGGGGTGACCGGTGCCGTGAACTTGGCCAAAGAGGCCA       TCCAGGGGGGCCTGGATACCACCAAGTCTATGGTCATGGGTACGAAAGACACGATGTCCACTGGGCTC       ACAGGGGCAGCGAATGTGGCCAAGGGGGCCATGCAAACTGGGCTGAACACAACCCAAAATATCGCAAC       AGGTACAAAGGACACCGTCTGCAGTGGGGTGACTGGTGCCATGAATTTGGCCAGAGGAACCATCCAGA       CAGGCGTGGACACCACCAAGATCGTTCTAACTGGTACCAAGGACACTGTCTGCAGTGGGGTCACCGGT       GCTGCGAATGTGGCCAAAGGGGCCGTCCAGGGCGGCCTGGACACTACAAAGTCTGTCCTGACTGGCAC       TAAAGATGCTGTGTCCACTGGGCTCACAGGGGCTGTGAACGTGGCCAAAGGGACCGTCCAGACCGGCG       TAGACACCACCAAGACTGTCCTAACCGGCACCAAGGACACCGTCTGCAGTGGGGTGACCAGTGCTGTG       AACGTGGCCAAAGGGGCCGTCCAGGGGGGCCTGGACACCACCAAGTCTGTGGTCATAGGTACAAAAGA       CACGATGTCCACTGGGCTCACGGGGGCAGCGAATGTGGCCAAGGGGGCTGTCCAGACAGGTGTAGACA       CAGCCAAGACCGTGCTGACCGGCACCAAGGACACAGTGACTACTGGGCTCGTGGGGGCAGTGAATGTC       CTACAGTGGGGTCACCAGTGCCGTGAACGTGGCCAAGGGGGCTGTGCAAACTGGGCTGAAAACGACCC       AAAATATCGCGACAGGTACAAAGAACACCTTTGGCAGTGGGGTGACCAGTGCTGTGAATGTGGCCAAA       GGGGCTGCCCAGACAGGTGTAGACACGGCCAAGACCGTGCTGACCGGCACCAAGGACACAGTCACTAC       TGGGCTCATGGGGGCAGTGAATGTCGCCAAAGGGACTGTCCAGACCAGTGTGGACACCACCAAGACTG       TCCTAACTGGTACCAAGGACACCGTCTGCAGTGGGGTGACCGGTGCTGCGAATGTGGCCAAAGGGGCC       ATCCAAGGGGGCCTGGACACTACAAAGTCTGTCCTGACTGGCACTAAAGATGCTGTGTCCACTGGGCT       CACAGGGGCTGTGAAGTTGGCCAAAGGGACTGTCCAGACCGGCATGGACACCACCAAGACTGTGTTAA       CTGGTACCAAGGATGCTGTGTGCAGTGGGGTGACCGGTGCTGCGAATGTGGCCAAGGGGGCCGTCCAG       ATGGGTGTAGACACGGCCAAGACCGTGCTGACCGGTACCAAGGACACTGTCTGCAGTGGGGTCACCGG       TGCTGCGAACGTGGCCAAGGGTGCTGTGCAAACTGGGCTGAAAACGACCCAAAATATCGCAACAGGTA       CAAAGAACACCCTTGGCAGTGGGGTGACCGGTGCTGCGAAAGTGGCCAAAGGGGCCGTCCAGGGGGGC       CTGGACACTACAAAGTCTGTCCTGACTGGCACTAAAGATGCCGTGTCCACTGGGCTCACAGGGGCTGT       GAACTTGGCCAAAGGGACTGTCCAGACCGGCGTGGACACCAGCAAGACTGTCCTGACCGGTACCAAGG       ACACCGTCTGCAGTGGAGTCACTGGTGCCGTAAATGTGGCCAAAGGGACCGTCCAGACAGGTGTGGAC       ACAGCCAAGACGGTGCTGAGTGGCGCTAAGGATGCAGTGACTACTGGAGTCACGGGGGCAGTGAATGT       GGCCAAAGGAACCGTGCAGACCGGCGTGGACGCCTCCAAGGCTGTGCTTATGGGTACCAAGGACACTG       TCTTCAGTGGGGTTACCGGTGCCATGAGCATGGCCAAAGGGGCCGTCCAGGGGGGCCTGGACACCACC       AAGACAGTGCTGACCGGAACCAAAGACGCAGTGTCCGCTGGGCTCATGGGGTCAGGGAACGTGGCGAC       AGGGGCCACCCACACTGGCCTCAGCACCTTCCAGAACTGGTTACCTAGTACCCCCGCCACCTCCTGGG       GTGGACTCACCAGTTCCAGGACCACAGACAATGGTGGGGAGCAGACTGCCCTGAGCCCCCAAGAGGCC       AGCCACTACCAAGGGCCTTGCGACTGACGTGGCGACGTTCACCCAAGGGGCCGCCCCAGGCAGGGAGG       ACACGGGGCTTTTGGCCACCACACACGGCCCCGAAGAAGCCCCACGCTTGGCAATGCTGCAGAATGAG       TTGGAGGGGCTGGGGGACATCTTCCACCCCATGAATGCGGAGGAGCAAGCTCAGCTGGCTGCCTCCCA       GCCTGGGCCAAAGGTGCTGTCGGCGGAACAGGGGAGCTACTTCGTTCGTTTAGGTGACCTGGGTCCCA       GCTTCCGCCAGCGGGCATTTGAACACGCGGTGAGCCACCTGCAGCACGGCCAGTTCCAAGCCAGGGAC       ACTCTGGCCCAGCTCCAGGACTGCTTCAGGCTGATTGAAAAGGCCCAGCAGGCTCCAGAAGGGCAGCC       ACGTCTGGACCAGGGCTCAGGTGCCAGTGCGGAGGACGCTGCTGTCCAGGAGGAGCGGGATGCCGGGG       TTCTGTCCAGGGTCTGCGGCCTTCTCCGGCAGCTGCACACGGCCTACAGTGGCCTGGTCTCCAGCCTC       CAGGGCCTGCCCGCCGAGCTCCAGCAGCCAGTGGGGCGGGCGCGGCACAGCCTCTGTGAGCTCTATGG       CATCGTGGCCTCAGCTGGCTCTGTAGAGGAGCTGCCCGCAGAGCGGCTGGTGCAGAGCCGCGAGGGTG       GCACCAGGCTTGGCAGGGGTTAGAGCAGCTGCTGGAGGGCCTACAGCACAATCCCCCGCTCAGCTGG       CTGGTAGGGCCCTTCGCCTTGCCCGCTGGCGGGCAG TAG                                           NOV32a, CG55906-04                       Protein Sequence   SEQ ID NO: 794   1372 aa   MW at 136019.4kD                     MSAPDEGRRDPPKPKGKTLGSFFGSLPGFSSARNLVANAHSSARARPAADPTGAPAAEAAQPQAQVAA           HPEQTAPWTEKELQPSEKQMVSGAKDLVCSKMSRAKDAVSSGVASVVDVAKGVVQGGLDTTRSALTGT       KEVVSSGVTGAMDMAKGAVQGGLDTSKAVLTGTKDTVSTGLTGAVNVAKGTVQAGVDTTKTVLTGTKD       TVTTGVMGAVNLAKGTVQTGVETSKAVLTGTKDAVSTGLTGAVNVARGSIQTGVDTSKTVLTGTKDTV       CSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCS       GVTGAMNVAKGTIQTGVDTTKTVLTGTKNTVCSGVTGAVNLAKEAIQGGLDTTKSMVMGTKDTMSTGL       TGAANVAKGAMQTGLNTTQNIATGTKDTVCSGVTGAMNLARGTIQTGVDTTKIVLTGTKDTVCSGVTG       AANVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNVAKGTVQTGVDTTKTVLTGTKDTVCSGVTSAV       NVAKGAVQGGLDTTKSVVIGTKDTMSTGLTGAANVAKGAVQTGVDTAKTVLTGTKDTVTTGLVGAVNV       AKGTVQTGMDTTKTVLTGTKDTIYSGVTSAVNVAKGAVQTGLKTTQNIATGTKNTFGSGVTSAVNVAK       GAAQTGVDTAKTVLTGTKDTVTTGLMGAVNVAKGTVQTSVDTTKTTLTGTKDTVCSGVTGAANVAKGA       IQGGLDTTKSVLTGTKDAVSTGLTGAVKLAXGTVQTGMDTTKTVLTGTKDAVCSGVTGAANVAKGAVQ       MGVDTAKTVLTGTKDTVCSGVTGAANVAKGAVQTGLKTTQNIATGTKNTLGSGVTGAAKVAKGAVQGG       LDTTKSVLTGTKDAVSTGLTGAVNLAKGTVQTGVDTSKTVLTGTKDTVCSGVTGAVNVAKGTVQTGVD       TAKTVLSGAKDAVTTGVTGAVNVAKGTVQTGVDASKAVLMGTKDTVFSGVTGAMSMAKGAVQGGLDTT       KTVLTGTKDAVSAGLMGSGNVATGATHTGLSTFQNWLPSTPATSWGGLTSSRTTDNGGEQTALSPQEA       PFSGISTPPDVLSVGPEPAWEAAATTKGLATDVATFTQGAAPGREDTGLLATTHGPEEAPRLAMLQNE       LEGLGDIFHPMNAEEQAQLAASQPGPKVLSAEQGSYFVRLGDLGPSFRQPAFEHAVSHLQHGQFQARD       TLAQLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDAAVQEERDAGVLSRVCGLLRQLHTAYSGLVSSL       QGLPAELQQPVGRARHSLCELYGIVASAGSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSW       LVGPFALPAGGQ                                     NOV32b, CG55906-05   SEQ ID NO: 795   6600 bp           DNA Sequence   ORF Start: ATG at 23   ORF Stop: TAG at 4337                       TCCAGCTTCTCACGTTCTCACT   ATG TCTGCTCCAGACGAAGGGAGACGGGATCCCCCCAAACCGAAGG           GCAAGACCCTGGGCAGCTTCTTTGGGTCCCTGCCTGGCTTCAACTCTGCCCGGAACCTGGTGGCCAAC       GCACATAGCTCGGCGAGAGCCCGGCCGGCCGCTGACCCCACAGGAGCGCCTGCTGCCGAGGCTGCCCA       ACCACAGGCTCAGGTGGCTGCCCACCCAGAGCAGACGGCCCCATGGACGGAGAAGGAGCTGCAACCTT       CGGAAAAGCAGATGGTGTCCGGGGCCAAAGACCTGGTGTGTTCCAAGATGTCCAGGGCCAAGGATGCC       GTGTCCTCCGGGGTGGCCAGCGTGGTGGACGTGGCTAAGGGAGTGGTCCAGGGAGGCCTGGACACCAC       TCGGTCTGCACTTACGGGCACCAAGGAGGCGGTGTCCAGCGGGGTCACAGGGGCCATGGACATGGCTA       AGGGGGCCGTCCAAGGGGGTCTGGACACCTCGAAGGCTGTCCTCACCGGCACCAAGGACACGGTGTCC       ACTGGGCTCACGGGGGCAGTGAATGTGGCCAAAGGGACCGTACAGGCCGGTGTGGACACCACCAAGAC       TGTGCTGACCGGCACCAAAGACACAGTGACTACTGGGGTCATGGGGGCAGTGAACTTGGCCAAAGGGA       CTGTCCAGACTGGCGTGGAAACCTCCAAGGCTGTGCTGACCGGCACCAAAGATGCTGTGTCCACTGGG       CTCACAGGGGCAGTGAATGTGGCCAGAGGAAGCATTCAGACCGGTGTGGACACCAGTAAGACTGTCCT       AACAGGTACCAAGGACACCGTCTGTAGTGGGGTGACCAGTGCCATGAATGTGGCCAAAGGAACCATCC       AGACCGGCGTGGACACCAGTAAGACTGTCCTAACAGGTACCAAGGACACCGTCTGTAGTGGGGTGACT       GGTGCCATGAATGTGGCCAAAGGAACCATCCAGACCGGCGTGGACACCAGTAAGACTGTCCTAACAGG       TACCAAGGACACCGTCTGTAGTGGGGTGACTGGTGCCATGAATGTGGCCAAAGGAACCATCCAGACCG       GCGTGGACACCACCAAGACTGTCCTAACTGGCACCAAGAACACTGTCTGCAGTGGGGTGACCGGTGCC       GTGAACTTGGCCAAAGAGGCCATCCAGGGGGGCCTGGATACCACCAAGTCTATGGTCATGGGTACGAA       AGACACGATGTCCACTGGGCTCACGGGGGCAGCGAATGTGGCCAAGGGGGCCATGCAAACTGGGCTGA       ACACAACCCAAAATATCGCAACAGGTACAAAGGACACCGTCTGCAGTGGGGTGACTGGTGCCATGAAT       TTGGCCAGAGGAACCATCCAGACAGGCGTGGACACCACCAAGATCGTTCTAACTGGTACCAAGGACAC       TGTCTGCAGTGGGGTCACCGGTGCTGCGAATGTGGCCAAAGGGGCCGTCCAGGGGGGCCTGGACACTA       CAAAGTCTGTCCTGACTGGCACTAAAGATGCTGTGTCCACTGGGCTCACAGGGGCTGTGAACGTGGCC       AAAGGGACCGTCCAGACCGGCGTAGACACCACCAAGACTGTCCTAACCGGCACCAAGGACACCGTCTG       CAGTGGGGTGACCAGTGCTGTGAACGTGGCCAAAGGGGCCGTCCAGGGGGGCCTGGACACCACCAAGT       CTGTGGTCATAGGTACAAAAGACACGATGTCCACTGGGCTCACGGGGGCAGCGAATGTGGCCAAGGGG       GCTGTCCAGACAGGTGTAGACACAGCCAAGACCGTGCTGACCGGCACCAAGGACACAGTGACTACTGG       GCTCGTGGGGGCAGTGAATGTCGCCAAAGGGACCGTCCAGACAGGCATGGACACCACCAAAACTGTCC       TAACCGGTACCAAGGACACCATCTACAGTGGGGTCACCAGTGCCGTGAACGTGGCCAAGGGGGCTGTG       CAAACTGGGCTGAAAACGACCCAAAATATCGCGACAGGTACAAAGAACACCTTTGGCAGTGGGGTGAC       CGGTGCTGTGAATGTGGCCAAAGGGGCCGTCCAGACAGGTGTAGACACAGCCAAGACCGTGCTGACCG       GCACCAAGGACACAGTCACTACTGGGCTCATGGGGGCAGTGAATGTCGCCAAAGGGACTGTCCAGACC       AGTGTGGACACCACCAAGACTGTCCTAACTGGTACCAAGGACACCGTCTGCAGTGGGGTGACCGGTGC       TGCGAATGTGGCCAAGGGGGCCGTCCAGACGGGTGTAGACACGGCCAAGACCGTGCTGACCGGTACCA       AGGACACTGTCTGCAGTGGGGTCACCGGTGCTGTGAACGTGGCCAAGGGTGCTGTGCAAACTGGGCTG       AAAACGACCCAAAATATCGCAACAGGTACAAAGAACACCCTTGGCAGTGGGGTGACCGGTGCTGCGAA       TGTGGCCAAAGGGGCCGTCCAGGGGGGCCTGGACACTACAAAGTCTGTCCTGACTGGCACTAAAGATG       CTGTGTCCACTGGGCTCACAGGGGCTGTGAACTTGGCCAAAGGGACTGTCCAGACCGGCATGGACACC       ACCAAGACTGTGTTAACTGGTACCAAGGATGCTGTGTGCAGTGGGGTGACCGGTGCTGCGAATGTGGC       CAAGGGGGCCGTCCAGACGGGTGTAGACACGGCCAAGACCGTGCTGACCGGCACCAAGGACACAGTCA       CTACTGGGCTCATGGGGGCAGTGAATGTCGCCAAAGGGACCGTCCAGACCAGTGTGGACACCACCAAG       ACTGTCCTAACTGGTACCAAGGACACCGTCTGCAGTGGGGTGACCGGTGCTGCGAATGTGGCCAAGGG       GGCCGTCCAGGGGGGCCTGGACACTACAAAGTCTGTCCTGACTGGCACTAAAGACACCGTATCCACTG       GGCTCACAGGGGCTGTGAACTTGGCCAAAGGGACTGTCCAGACCGGCGTGGACACCAGCAAGACTGTC       CTGACCGGTACCAAGGACACCGTCTGCAGTGGAGTCACTGGTGCCGTAAATGTGGCCAAAGGCACCGT       CCAGACAGGTGTGGACACAGCCAAGACGGTGCTGAGTGGCGCTAAGGATGCAGTGACTACTGGAGTCA       CGGGGGCAGTGAATGTGGCCAAAGGAACCGTGCAGACCGGCGTGGACGCCTCCAAGGCTGTGCTTATG       GGTACCAAGGACACTGTCTTCAGTGGGGTTACCGGTGCCATGAGCATGGCCAAAGGGGCCGTCCAGGG       GGGCCTGGACACCACCAAGACAGTGCTGACCGGAACCAAW3ACGCAGTGTCCGCTGGGCTCATGGGGT       CAGGGAACGTGGCGACAGGGGCCACCCACACTGGCCTCAGCACCTTCCAGAACTGGTTACCTAGTACC       CCCGCCACCTCCTGGGGTGGACTCACCAGTTCCAGGACCACAGACAATGGTGGGGAGCAGACTGCCCT       GAGCCCCCAAGAGGCCCCGTTCTCTGGCATCTCCACGCCCCCGGATGTGCTCAGTGTAGGCCCGGAGC       CTGCCTGGGAAGCCGCAGCCACTACCAAGGGCCTTGCGACTGACGTGGCGACGTTCACCCAAGGGGCC       GCCCCAGGCAGGGAGGACACGGGGCTTTTGACCACCACACACGGCCCCGAAGAAGCCCCACGCTTGGC       AATGCTGCAGAATGAGTTGGAGGGGCTGGGGGACATCTTCCACCCCATGAATGCGGAGGAGCAAGCTC       AGCTGGCTGCCTCCCAGCCCGGGCCAAAGGTGCTGTCGGCGGAACAGGGGAGCTACTTCGTTCGTTTA       GGTGACCTGGGTCCCAGCTTCCGCCAGCGGGCATTTGAACACGCGGTGAGCCACCTGCAGCACGGCCA       GTTCCAAGCCAGGGACACTCTGGCCCAGCTCCAGGACTGCTTCAGGCTGATTGAAAAGGCCCAGCAGG       CTCCAGAAGGGCAGCCACGTCTGGACCAGGGCTCAGGTGCCAGTGCGGAGGACGCTGCTGTCCAGGAG       GAGCGGGATGCCGGGGTTCTGTCCAGGGTCTGCGGCCTTCTCCGGCAGCTGCACACGGCCTACAGTGG       CCTGGTCTCCAGCCTCCAGGGCCTGCCCGCCGAGCTCCAGCAGCCAGTGGGGCGGGCGCGGCACAGCC       TCTGTGAGCTCTATGGCATCGTGGCCTCAGCTGGCTCTGTAGAGGAGCTGCCCGCAGAGCGGCTGGTG       CAGAGCCGCGAGGGTGTGCACCAGGCTTGGCAGGGGTTAGAGCAGCTGCTGGAGGGCCTACAGCACAA       TCCCCCGCTCAGCTGGCTGGTAGGGCCCTTCGCCTTGCCCGCTGGCGGGCAG TAG   CTGTAGGAGCCTG           CAGGCCCGGCGCGGGGTCGCCCTGCTCTGTCCAGGGAGGAGCTGCCTCAGAACTTTCTCCCCGCCCCC           AAACCTGGATCGGTTCCCTAAAGCCCTAGACCTTTGGGGCTGCAGCTGGCTGAGCGCCGAGGGGCTGC           GGAGGCAGTGACCTTCTTAACTGAGCCACCCCACGCCCTGCTCCGGGCCTGCCTGCATCTCCCACCTC           CTCCCCAGCGCTGCCTGCCCCTCTCGGAGCCTGGGGTCACTCAGACCACCAGCCAAGAGCCTTCCCTT           GAAGTCCCCAAGCAAGCACTGCAATTAGGAAAGAGAAAAAGCAGCGTGCCCAGCCTGGAAGGGGATCT           GTTTGCCCCGCTAGCAACCCTTTTATATCTAGCAGGGCTCTTCCAGTCCTGCAGCACGGGCCCCCAGC           TATCAGCGGTGCAGGCAGTGCTGTGGCATCCCAGGCTCCGGGCAGCTCCGTTCTCATGCTGAAAGTGG           GTCTCCGGCCTTAGCACACACACCTTGAGGGTCTTAAGAACCACATTCCCTCATAGTAGAAAGTACTA           GAAAAAGCGACACTGCCATCATCATCCCAAGGCAGGCTGCTACTGCCTTTGCTGACCCCCGGGGTGGC           CTCACGGTGGGGACAAAGCTGCCAGGAGCCACAGCAGCCACAGCTGGGGCTTTGCACCAGCCTGGCTT           GAGACTGAGCAGTTTGCAGGGGGTGGGGGGTGCAAAAAACAAGCAAACAGGCTGCTGCTGCCTCCAGC           TGCCCACCACAGGCCTGCCCCAGGCACCTGGGGCTCTGAGGCCCCTGGGGAGGCTGGGCCCAAAAGCT           GCCCCTGGAGACACAGACAAAGGACTTCCCCGCAGGGAACTGTGCCCTATGGAGGGATCAGACAGGAA           CTGGGAACAGCCACAGAGGCTGCGTGCCTATGGCACAGCCCTTCCTCCGCCGCACACTCCCCCTGAAT           CCTCAGGCCCACCCAAGCGCCGGGCTGCAGAGGAAGCGGGGCTGGGGAGGCTGCAGGCATCAGAGACA           CTGGTGGTGGCGGACCCGGCCGCCGGGCCCCGTGCTCTCAGGCTAGCCCAGGTCGTGGAGGCTGGCAG           GCTCAGGTCGGGTGTGAGACGTGCCGTGGCTGCGCTCAGTCCAGCGGGGAGGAGCCGTTCAGCCCAAC           CTCCCCAGGAAGCCATATCCCCACTCACCCGGTAAGAGAACCTTGTCGTCCCCTTTCCATGCTCTCCT           AGGACACGAGCCCAGGAACCCCAGACCCAGGGGGAGGAAGGGTGGAGGGGCCCCAGGGGTCACCATGT           GCACCAGGGGCCGTGAGGGGCCGGGGCATTCAGCTCAGCTCTGAACCGGGGAAGCTGGCACGGCAAGG           ACTGCCTCAGGTGACGGGCCGTGAGAGGGGACGGGTCAGGAGCCTTCCCAAGCCTTCTCCTCAGCCCG           ACACCCATGGCCATCGGAGGCTAGGATGCCAGACACAGCCATTTGCAGAAATCAGGCACAGTGACTGC           AGCTCACGTCCAGCCAACCAAGCATGGGGCCGCAGCTCAGGAAGTCCCTTCCCGCCACACCACAGCCT           AATTCTTACTGGGACGGAGGCAACTCGGCTACGCTGGGCAGGACGACAAACACGAGACGCCACTGTGG           AATGAGCAACTTCGGAGCACGGGGTGACTTGCTTGGGACCGTGCCCACGTGACAGCCCCTTATGCAGA           GGAGGAAAGAGAAGCCCCGAGTGGGAGGGGAACCTGTCCAAAGTCACACGGTGTGTGGGTGACACAGC           TGGGGTGAGTCGAGGCTGGCCCCTGAGGCCCATGCTCCCTGAACGCTGGAGACCACTGTCGGCTAGCC           GCGGCTCTCAGGGAAGGCCTGGTCTCCACCCTCCCAGCCTAGCCTCGCGGACCCTCGTCCTCCCCACA           TCGGACCTGCTCACCTGCCTGGACCCTGGGCTGCCAGATGCAGGAAGCATCAAACCCCCCAGCCTCGT           GGGTGCGGGGCAGGGCGCAGGCAGCACAGCTTAGATGCCCTGGTTTGTCCCTCTTGTCTCCTGGGAAG           AGCTTGCTCCCGCCCAGCTCTCCTGCCACTGGCCTTTCAGGGTTGGGCTGGGCCCAGAGTGCCTTTTA           GTCGCTTCTCACGGTGGCCTGATGGCTCAACCCAGTCCCAAACGGGCCCAGTGACACTGCCGACTGCG           CCCCAGCTCAGGCCCCCACTGCACCAGCAATGCTAGAAAACCAAGCCAATAAAAGTGATTTCTTTTTT           CATT                                           NOV32b, CG55906-05                       Protein Sequence   SEQ ID NO: 796   1438 aa   MW at 142443.5kD                     MSAPDEGRRDPPKPKGKTLGSFFGSLPGFNSARNLVANAHSSARARPAADPTGAPAAEAAQPQAQVAA           HPEQTAPWTEKELQPSEKQMVSGAKDLVCSKMSRAKDAVSSGVASVVDVAKGVVQGGLDTTRSALTGT       KEAVSSGVTGAMDMAKGAVQGGLDTSKAVLTGTKDTVSTGLTGAVNVAKGTVQAGVDTTKTVLTGTKD       TVTTGVMGAVNLAKGTVQTGVETSKAVLTGTKDAVSTGLTGAVNVARGSIQTGVDTSKTVLTGTKDTV       CSGVTSAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCS       GVTGAMNVAKGTIQTGVDTTKTVLTGTKNTVCSGVTGAVNLAKEAIQGGLDTTKSMVMGTKDTMSTGL       TGAANVAKGAMQTGLNTTQNIATGTKDTVCSGVTGAMNLARGTIQTGVDTTKIVLTGTKDTVCSGVTG       AANVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNVAKGTVQTGVDTTKTVLTGTKDTVCSGVTSAV       NVAKGAVQGGLDTTKSVVIGTKDTMSTGLTGAANVAKGAVQTGVDTAKTVLTGTKDTVTTGLVGAVNV       AKGTVQTGMDTTKTVLTGTKDTIYSGTSAVNVAKGAVQTGLKTTQNIATGTKNTFGSGVTGAAVNVAK       GAVQTGVDTAKTVLTGTKDTVTTGLMGAVNVAKGTVQTSVDTTKTVLTGTKDTVCSGVTGAANVAXGA       VQTGVDTAKTVLTGTKDTVCSGVTGAVVAKGAVQTGLKTTQNIATGTKNTLGSGVTGAAANVAKGAVQ       GGLDTTKSVLTGTKDAVSTGLTGAVNLAKGTVQTGMDTTKTVLTGTKDAVCSGVTGAANVAKGAVQTG       VDTAKTVLTGTKDTVTTGLMGAVNVAKGTVQTSVDTTKTVLTGTKDTVCSGVTGAANVAKGAVQGGLD       TTKSVLTGTKDTVSTGLTGAVNLAKGTVQTGDVTSKTVLTGTKDTVCSGVTGAVNVAKGTVQTGVDTA       KTVLSGAKDAVTTGVTGAVNVAKGTVQTGVDASKAVLMGTKDTVFSGVTGAMSMAKGAVQGGLDTTKT       VLTGTKDAVSAGLMGSGNVATGATHTGLSTFQNWLPSTPATSWGGLTSSRTTDNGGEQTALSPQEAPF       SGISTPPDVLSVGPEPAVVEAATTKGLATDVATFTQGAAPGREDTGLLTTTHGPEEAPRLAMLQNELE       GLDIFHPMNAEEQAQLAASQPGPKVLSAEQGSYFVRLGDLGPSFRQRAFEHAVSHLQHGAQFQARDTL       AQLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDAAVQEERDAGVLSRVCGLLRQLHTAYSGLVSSLQG       LPAELQQPVGRARHSLCELYGIVASAGSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLV       GPFALPAGGQ                                     NOV32c, CG55906-01   SEQ ID NO: 797   3839 bp           DNA Sequence   ORF Start: ATG at 131   ORF Stop: TAG at 3806                       GTGAGGCCAGGCCTGCAGGTGGGTGTCGGGCTGCTCAGGCTTTCAGTGGGGAGTGGGTCTGGGATGGG               AGGCTAGGGAACCCCCATTCACGCACCTTCTCTGCCCCCTTCCAGCTTCTCACGTTCTCACT   ATG TCT       GCTCCAGACGAAGGGAGACGGGATCCCCCCAAACCGAAGGGCAAGCCCCCCGCCCCCATGCAGACCCT       GGGCAGCTTCTTTGGGTCCCTGCCTGGCTTCAGCTCTGCCCGGAACCTGGTGGCCAACGCACATAGCT       CGGTCGGGGCCAAAGACCTGGTGTGTTCCAAGATGTCCAGGGCCAAGGATGCCGTGTCCTCCGGGGTG       GCCAGCGTGGTGGACGTGGCTAAGGGAGTGGTCCAGGGAGGCCTGGACACCACTCGGTCTGCACTTAC       GGGCACCAAGGAGGTGGTGTCCAGCGGGGTCACAGGGGCCATGGACATGGCTAAGGGGGCCGTCCAAG       GGGGTCTGGACACCTCGAAGGCTGTCCTCACCGGCACCAAGGACACGGTGTCCACTGGGCTCACGGGG       GCAGTGAATGTGGCCAAAGGGACCGTACAGGCCGGTGTGGACACCACCAAGACTGTGCTGACCGGCAC       CAAAGACACAGTGACTACTGGGGTCATGGGGGCAGTGAACTTGGCCAAAGGGACTGTCCAGACTGGCG       TGGAAACCTCCAAGGCTGTGCTGACCGGCACCAAAGATGCTGTGTCCACTGGGCTCACAGGGGCAGTG       AATGTGGCCAGAGGAAGCATTCAGACCGGTGTGGACACCAGTAAGACTGTCCTAACAGGTACCAAGGA       CACCGTCTGTAGTGGGGTGACTGGTGCCATGAATGTGGCCAAAGGAACCATCCAGACCGGCGTGGACA       CCAGTAAGACTGTCCTAACAGGTACCAAGGACACCGTCTGTAGTGGGGTGACTGGTGCCATGAATGTG       GCCAAAGGAACCATCCAGACCGGCGTGGACACCAGTAAGACTGTCCTAACAGGTACCAAGGACACCGT       CTGTAGTGGGGTGACTGGTGCCATGAATGTGGCCAAAGGAACCATCCAGACCGGCGTGGACACCACCA       AGACTGTCCTAACTGGCACCAAGAACACTGTCTGCAGTGGGGTGACCGGTGCCGTGAACTTGGCCAAA       GAGGCCATCCAGGGGGGCCTGGATACCACCAAGTCTATGGTCATGGGTACGAAAGACACGATGTCCAC       TGGGCTCACAGGGGCAGCGAATGTGGCCAAGGGGGCCATGCAAACTGGGCTGAACACAACCCAAAATA       TCGCAACAGGTACAAAGGACACCGTCTGCAGTGGGGTGACTGGTGCCATGAATTTGGCCAGAGGAACC       ATCCAGACAGGCGTGGACACCACCAAGATCGTTCTAACTGGTACCAAGGACACTGTCTGCAGTGGGGT       CACCGGTGCTGCGAATGTGGCCAAAGGGGCCGTCCAGGGCGGCCTGGACACTACAAAGTCTGTCCTGA       CTGGCACTAAAGATGCTGTGTCCACTGGGCTCACAGGGGCTGTGAACGTGGCCAAAGGGACCGTCCAG       ACCGGCGTAGACACCACCAAGACTGTCCTAACCGGCACCAAGGACACCGTCTGCAGTGGGGTGACCAG       TGCTGTGAACGTGGCCAAAGGGGCCGTCCAGGGGGGCCTGGACACCACCAAGTCTGTGGTCATAGGTA       CAAAAGACACGATGTCCACTGGGCTCACGGGGGCAGCGAATGTGGCCAAGGGGGCTGTCCAGACAGGT       GTAGACACAGCCAAGACCGTGCTGACCGGCACCAAGGACACAGTGACTACTGGGCTCGTGGGGGCAGT       GAATGTCGCCAAAGGGACCGTCCAGACAGGCATGGACACCACCAAAACTGTCCTAACCGGTACCAAGG       ACACCATCTACAGTGGGGTCACCAGTGCCGTGAACGTGGCCAAGGGGGCTGTGCAAACTGGGCTGAAA       ACGACCCAAAATATCGCGACAGGTACAAAGAACACCTTTGGCAGTGGGGTGACCAGTGCTGTGAATGT       GGCCAAAGGGGCTGCCCAGACAGGTGTAGACACGGCCAAGACCGTGCTGACCGGCACCAAGGACACAG       TCACTACTGGGCTCATGGGGGCAGTGAATGTCGCCAAAGGGACTGTCCAGACCAGTGTGGACACCACC       AAGACTGTCCTAACTGGTACCAAGGACACCGTCTGCAGTGGGGTGACCGGTGCTGCGAATGTGGCCAA       AGGGGCCATCCAAGGGGGCCTGGACACTACAAAGTCTGTCCTGACTGGCACTAAAGATGCTGTGTCCA       CTGGGCTCACAGGGGCTGTGAAGTTGGCCAAAGGGACTGTCCAGACCGGCATGGACACCACCAAGACT       GTGTTAACTGGTACCAAGGATGCTGTGTGCAGTGGGGTGACCGGTGCTGCGAATGTGGCCAAGGGGGC       CGTCCAGATGGGTGTAGACACGGCCAAGACCGTGCTGACCGGTACCAAGGACACTGTCTGCAGTGGGG       TCACCGGTGCTGCGAACGTGGCCAAGGGTGCTGTGCAAACTGGGCTGAAAACGACCCAAAATATCGCA       ACAGGTACAAAGAACACCCTTGGCAGTGGGGTGACCGGTGCTGCGAAAGTGGCCAAAGGGGCCGTCCA       GGGGGGCCTGGACACTACAAAGTCTGTCCTGACTGGCACTAAAGATGCCGTGTCCACTGGGCTCACAG       GGGCTGTGAACTTGGCCAAAGGGACTGTCCAGACCGGCGTGGACACCAGCAAGACTGTCCTGACCGGT       ACCAAGGACACCGTCTGCAGTGGAGTCACTGGTGCCGTAAATGTGGCCAAAGGGACCGTCCAGACAGG       TGTGGACACAGCCAAGACGGTGCTGAGTGGCGCTAAGGATGCAGTGACTACTGGAGTCACGGGGGCAG       TGAATGTGGCCAAAGGAACCGTGCAGACCGGCGTGGACGCCTCCAAGGCTGTGCTTATGGGTACCAAG       GACACTGTCTTCAGTGGGGTTACCGGTGCCATGAGCATGGCCAAAGGGGCCGTCCAGGGGGGCCTGGA       CACCACCAAGACAGTGCTGACCGGAACCAAAGACGCAGTGTCCGCTGGGCTCATGGGGTCAGGGAACG       TGGCGACAGGGGCCACCCACACTGGCCTCAGCACCTTCCAGAACTGGTTACCTAGTACCCCCGCCACC       TCCTGGGGTGGACTCACCAGTTCCAGGACCACAGCTCAGCTGGCTGCCTCCCAGCCTGGGCCAAAGGT       GCTGTCGGCGGAACAGGGGAGCTACTTCGTTCGTTTAGGTGACCTGGGTCCCAGCTTCCGCCAGCGGG       CATTTGAACACGCGGTGAGCCACCTGCAGCACGGCCAGTTCCAAGCCAGGGACACTCTGGCCCAGCTC       CAGGACTGCTTCAGGCTGATTGAAAAGGCCCAGCAGGCTCCAGAAGGGCAGCCACGTCTGGACCAGGG       CTCAGGTGCCAGTGCGGAGGACGCTGCTGTCCAGGAGAGGGTCTGCGGCCTTCTCCGGCAGCTGCACA       CGGCCTACAGTGGCCTGGTCTCCAGCCTCCAGGGCCTGCCCGCCGAGCTCCAGCAGCCAGTGGGGCGG       GCGCGGCACAGCCTCTGTGAGCTCTATGGCATCGTGGCCTCAGCTGGCTCTGTAGAGGAGCTGCCCGC       AGAGCGGCTGGTGCAGAGCCGCGAGGGTGTGCACCAGGCTTGGCAGGGGTTAGAGCAGCTGCTGGAGG       GCCTACAGCACAATCCCCCGCTCAGCTGGCTGGTAGGGCCCTTCGCCTTGCCCGCTGGCGGGCAG TAG           CTGTAGGAGCCTGCAGGCCCGGCGCGGGGTC                                           NOV32c, CG55906-01                       Protein Sequence   SEQ ID NO: 798   1225 aa   MW at 120831.1kD                     MSAPDEGRPDPPKPKGKPPAPMQTLGSFFGSLPGFSSARNLVANAHSSVGAKDLVCSKMSRAKDAVSS           GVASVVDVAKGVVQGGLDTTRSALTGTKEVVSSGVTGAMDMAKGAVQGGLDTSKAVLTGTKDTVSTGL       TGAVNVAKGTVQAGVDTTKTVLTGTKDTVTTGVMGAVNLAKGTVQTGVETSKAVLTGTKDAVSTGLTG       AVNVARGSIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAM       NVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTTKTVLTGTKNTVCSGVTGAVNL       AKEAIQGGLDTTKSMVMGTKDTMSTGLTGAANVAKGAMQTGLNTTQNIATGTKDTVCSGVTGAMNLAR       GTIQTGVDTTKIVLTGTKDTVCSGVTGAANVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNVAKGT       VQTGVDTTKTVLTGTKDTVCSGVTSAVNVAKGAVQGGLDTTKSVVIGTKDTMSTGLTGAANVAKGAVQ       TGVDTAKTVLTGTKDTVTTGLVGAVNVAKGTVQTGMDTTKTVLTGTKDTIYSGVTSAVNVAKGAVQTG       LKTTQNIATGTKNTFGSGVTSAVNVAKGAAQTGVDTAKTVLTGTKDTVTTGLMGAVNVAKGTVQTSVD       TTKTVLTGTKDTVCSGVTGAANVAKGAIQGGLDTTKSVLTGTKDAVSTGLTGAVKVAKGTVQTGMDTT       KTVLTGTKDAVCSGVTGAANVAKGAVQMGVDTAXTVLTGTKDTVCSGVTGAANVAKGAVQTGLKTTQN       IATGTKNTLGSGVTGAAKVAXGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNLAKGTVQTGVDTSKTVL       TGTKDTVCSGVTGAVNVAKGTVQTGVDTAKTVLSGAKDAVTTGVTGAVNVAKGTVQTGVDASKAVLMG       TKDTVFSGVTGAMSMAKGAVQGGLDTTKTVLTGTKDAVSAGLMGSGNVATGATHTGLSTFQNWLPSTP       ATSWGGLTSSRTTAQLAASQPGPKVLSAEQGSYFVRRGDLGPSFRQRAFEHAVSHLQHGQFQARDTLA       QLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDAAVQERVCGLLRQLHTAYSGLVSSLQGLPAELQQPV       GRARHSLCELYGIVASAGSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGG       Q                                     NOV32d, 277901794   SEQ ID NO: 799   2247 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     AGATCTATCATGTCTGCTCCAGACGAAGGGAGACGGGATCCCCCCAAACCGAAGGGCAAGACCCTGGG           CAGCTTCTTTGGGTCCCTGCCTGGCTTCAGCTCTGCCCGGAACCTGGTGGCCAACGCACATAGCTCGG       GTGGCTGCCCACCCAGAGCAGACGGCCCCATGGACGGAGAAGGAGCTGCAACCTTCGGAAAAGATGGT       GTCCGGGGCCAAAGACCTGGTGTGTTCCAAGATGTCCAGGGCCAAGGATGCCGTGTCCTCCGGGGTGG       CCAGCGTGGTGGACGTGGCTACGGGAGTGGTCCAGGGAGGCCTGGACACCACTCGGTCTGCACTTACG       GGCACCAAGGAGGCGGTGTCCAGCGGGTTCACAGGGGCCATGGACATGGCTAAGGGGGCCGTCCAAGG       GGGTCTGGACACCTCGAAGGCTGTCCTCACCGGCACCAAGGACACGGTGTCCACTGGGCTCACGGGGG       CAGTGAATGTGGCCAAAGGGACCGTACAGGCCGGTGTGGACACCACCAAGACTGTGCTGACCGGCACC       AAAGACACAGTGACTACTGGGGTCATGGGGGCAGTGAACTTGGCCAAAGGGACTGTCCAGACTGGCGT       GGAAACCTCCAAGGCTGTGCTGACCGGCACCAAAGATGCTGTGTCCACTGGGCTCACAGGGGCAGTGA       ATGTGGCCAGAGGAAGCATTCAGACCGGTGTGGACACCAGTAAGACTGTCCTAACAGGTACCAAGGAC       ACCGTCTGTAGTGGGGTGACCAGTGCCATGAATGTGGCCAAAGGAACCATCCAGACCGGCGTGGACAC       CAGCAAGACTGTCCTGACCGGTACCTTGGACACCGTCTGCAGTGGAGTCACTGGTGCCGTAAATGTGG       CCAAAGGCACCGTCCAGACAGGTGTGGACACAGCCAAGACGGTGCTGAGTGGCGCTAAGGATGCAGTG       GGCTGTGCTTATGGGTACCAAGGACACTGTCTTCAGTGGGGTTACCGGTGCCATGAGCATGGCCAAAG       GGGCCGTCCAGGGGGGCCTGGACACCACCAAGACAGTGCTGACCGGAACCAAAGACGCAGTGTCCGCT       GGGCTCATGGGGTCAGGGAACGTGGCGACAGGGGCCACCCACACTGGCCTCAGCACCTTCCAGAACTG       GTTACCTAGTACCCCCGCCACCTCCTGGGGTGGACTCACCAGTTCCAGGACCACAGACAATGGTGGGG       AGCAGACTGCCCTGAGCCCCCAAGAGGCCCCGTTCTCTGGCATCTCCACGCCCCCGGATGTGCTCAGT       GTAGGCCCGGAGCCTGCCTGGGAAGCCGCAGCCACTACCAAGGGCCTTGCGACTGACGTGGCGACGTT       CACCCAAGGGGCCGCCCCAGGCAGGGAGGACACGGGGCTTTTGACCACCACACACGGCCCCGAAGAAG       CCCCACGCTTGGCAATGCTGCAGAATGAGTTGGAGGGGCTGGGGGACATCTTCCACCCCATGAATGCG       GAGGAGCAAGCTCAGCTGGCTGCCTCCCAGCCCGGGCCAAAGGTGCTGTCGGCGGAACAGGGGAGCTA       TGCAGCACGGCCAGTTCCAAGCCAGGGACACTCTGGCCCAGCTCCAGGACTGCTTCAGGCTGATTGAA       TGCTGTCCAGGAGGAGCGGGATGCCGGGGTTCTGTCCAGGGTCTGCGGCCTTCTCCGGCAGCTGCACA       CGGCCTACAGTGGCCTGGTCTCCAGCCTCCAGGGCCTGCCCGCCGAGCTCCAGCAGCCAGTGGGGCGG       GCGCGGCACAGCCTCTGTGAGCTCTATGGCATCGTGGCCTCAGCTGGCTCTGTAGAGGAGCTGCCCGC       AGAGCGGCTGGTGCAGAGCCGCGAGGGTGTGCACCAGGCTTGGCAGGGGTTAGAGCAGCTGCTGGAGG       GCCTACAGCACAATCCCCCGCTCAGCTGGCTGGTAGGGCCCTTCGCCTTGCCCGCTGGCGGGCAGCTC       GAG                                         NOV32d, 277901794                       Protein Sequence   SEQ ID NO: 800   749 aa   MW at 75993.5kD                     RSIMSAPDEGRRDPPKPKGKTLGSFFGSLPGFSSARNLVANAHSSARARPAADPTGAPAAEAAQPQAQ           VAAHPEQTAPWTEKELQPSEKMVSGAKDLVCSKMSRAKDAVSSGVASVVDVATGVVQGGLDTTRSALT       GTKEAVSSGFTGAMDMAKGAVQGGLDTSKAVLTGTKDTVSTGLTGAVNVAKGTVQAGVDTTKTVLTGT       KDTVTTGVMGAVNLAKGTVQTGVETSKAVLTGTKDAVSTGLTGAVNVARGSIQTGVDTSKTVLTGTKD       TVCSGVTSAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAVNVAKGTVQTGVDTAKTVLSGAKDAV       GLMGSGNVATGATHTGLSTFQNWLPSTPATSWGGLTSSRTTDNGGEQTALSPQEAPFSGISTPPDVLS       VGPEPAWEAAATTKGLATDVATFTQGAAPGREDTGLLTTTHGPEEAPRLAMLQNELEGLGDIFHPNNA       EEQAQLAASQPGPKVLSAEQGSYFVRLGDLGPSFRQRAFEHAVSHLQHGQFQARDTLAQLQDCFRLIE       KAQQAPEGQPRLDQGSGASAEDAAVQEERDAGVLSRVCGLLRQLHTAYSGLVSSLQGLPAELQQPVGR       ARHSLCELYGIVASAGSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGGQL       E                                     NOV32e, CG55906-02   SEQ ID NO: 801   810 bp           DNA Sequence   ORF Start: ATG at 123   ORF Stop: TAG at 792                       AGGCCTGCAGGTGGGTGTCGGGCTGCTCAGGCTTTCAGTGGGGAGTGGGTGTGGGATGGGAGGCTAGG               GAACCCCCATTCACGCACCTTCTCTGCCCCCTTCCAGCTTCTCACGTTCTCACT   ATG TCTGCTCCAGA       CGAAGGGAGACGGGATCCCCCCAAACCGAAGGGCAAGACCCTGGGCAGCTTCTTTGGGTCCCTGCCTG       GCTTCAACTCTGCCCGGAACCTGGTGGCCAACGCACATAGCTCGGCGAGAGCCCGGCCGGCCGCTGAC       CCCACAGGAGCGCCTGCTGCCGAGGCTGCCCAACCACAGGCTCAGGTGGCTGCCCACCCAGAGCAGAC       GGCCCCATGGACGGAGAAGGAGCTGCAACCTTCGGAAAAGATTGAAAAGGCCCAGCAGGCTCCAGAAG       GGCAGCCACGTCTGGACCAGGGCTCAGGTGCCAGTGCGGAGGACGCTGCTGTCCAGGAGGAGCGGGAT       GCCGGGGTTCTGTCCAGGGTCTGCGGCCTTCTCCGGCAGCTGCACACGGCCTACAGTGGCCTGGTCTC       CAGCCTCCGGGGCCTGCCCGCCGAGCTCCAGCAGCCAGTGGGGCGGGCGCGGCACAGCCTCTGTGAGC       TCTATGGCATCGTGGCCTCAGCTGGCTCTGTAGAGGAGCTGCCCGCAGAGCGGCTGGTGCAGAGCCGC       GAGGGTGTGCACCAGGCTTGGCAGGGGTTAGAGCAGCTGCTGGAGGGCCTACAGCACAATCCCCCGCT       CAGCTGGCTGGTAGGGCCCTTCGCCTTGCCCGCTGGCGGGCAG TAG   CTGTAGGAGCCTGCAG                                           NOV32e, CG55906-02                       Protein Sequence   SEQ ID NO: 802   223 aa   MW at 23486.9kD                     MSAPDEGRRDPPKPKGKTLGSFFGSLPGFNSARNLVANAHSSARARPAADPTGAPAAEAAQPQAQVAA           HPEQTAPWTEKELQPSEKIEKAQQAPEGQPRLDQGSGASAEDAAVQEERDAGVLSRVCGLLRQLHTAY       SGLVSSLRGLPAELQQPVGRARHSLCELYGIVASAGSVEELPAERLVQSREGVHQAWQGLEQLLEGLQ       HNPPLSWLVGPFALPAGGQ                                     NOV32f, 230272941   SEQ ID NO: 803   714 bp           DNA Sequence   ORF Start: at 2   ORF Stop: TGA at 692                       G GCGCGCCCACCCTTCACCACCATGTCTGCTCCAGACGAAGGGAGACGGGATCCCCCCAAACCGAAGG           GCAAGACCCTGGGCAGCTTCTTTGGGTCCCTGCCTGGCTTCAGCTCTGCCCGGAACCTGGTGGCCAAC       GCACATAGCTCGGCGAGAGCCCGGCCGGCCGCTGACCCCACAGGAGCGCCTGCTGCCGAGGCTGCCCA       ACCACAGGCTCAGGTGGCTGCCCACCCAGAGCAGACGGCCCCATGGACGGAGAAGGAGCTGCAACCTT       CGGAAAAGATTGAAAAGGCCCAGCAGGCTCCAGAAGGGCAGCCACGTCTGGACCAGGGCTCAGGTGCC       AGTGCGGAGGACGCTGCTGTCCAGGAGGAGCGGGATGCCGGGGTTCTGTCCAGGGTCTGCGGCCTTCT       CCGGCAGCTGCACACGGCCTACAGTGGCCTGGTCTCCAGCCTCCAGGGCCTGCCCGCCGAGCTCCAGC       AGCCAGTGGGGCGGGCGCGGCACAGCCTCTGTGAGCTCTATGGCATCGTGGCCTCAGCTGGCTCTGTA       GAGGAGCTGCCCGCAGAGCGGCTGGTGCAGAGCCGCGAGGGTGTGCACCAGGCTTGGCAGGGGTTAGA       GCAGCTGCTGGAGGGCCTACAGCACAATCCCCCGCTCAGCTGGCTGGTAGGGCCCTTCGCCTTGCCCG       CTGGCGGGCAG TGA   AGGGGGCGGCCGCGGAGCCT                                           NOV32f, 230272941                       Protein Sequence   SEQ ID NO: 804   230 aa   MW at 24202.7kD                     ARPPFTTMSAPDEGRRDPPKPKGKTLGSFFGSLPGFSSARNLVANAHSSAPARPAADPTGAPAAEAAQ           PQAQVAAHPEQTAPWTEKELQPSEKIEKAQQAPEGQPRLDQGSGASAEDAAVQEERDAGVLSRVCGLL       RQLHTAYSGLVSSLQGLPAELQQPVGRARHSLCELYGIVASAGSVEELPAERLVQSREGVHQAWQGLE       QLLEGLQHNPPLSWLVGPFALPAGGQ                                     NOV32g, CG55906-03   SEQ ID NO: 805   714 bp           DNA Sequence   ORF Start: ATG at 23   ORF Stop: TGA at 692                       GGCGCGCCCACCCTTCACCACC   ATG TCTGCTCCAGACGAAGGGAGACGGGATCCCCCCAAACCGAAGG           GCAAGACCCTGGGCAGCTTCTTTGGGTCCCTGCCTGGCTTCAGCTCTGCCCGGAACCTGGTGGCCAAC       GCACATAGCTCGGCGAGAGCCCGGCCGGCCGCTGACCCCACAGGAGCGCCTGCTGCCGAGGCTGCCCA       ACCACAGGCTCAGGTGGCTGCCCACCCAGAGCAGACGGCCCCATGGACGGAGAAGGAGCTGCAACCTT       CGGAAAAGATTGAAAAGGCCCAGCAGGCTCCAGAAGGGCAGCCACGTCTGGACCAGGGCTCAGGTGCC       AGTGCGGAGGACGCTGCTGTCCAGGAGGAGCGGGATGCCGGGGTTCTGTCCAGGGTCTGCGGCCTTCT       CCGGCAGCTGCACACGGCCTACAGTGGCCTGGTCTCCAGCCTCCAGGGCCTGCCCGCCGAGCTCCAGC       AGCCAGTGGGGCGGGCGCGGCACAGCCTCTGTGAGCTCTATGGCATCGTGGCCTCAGCTGGCTCTGTA       GAGGAGCTGCCCGCAGAGCGGCTGGTGCAGAGCCGCGAGGGTGTGCACCAGGCTTGGCAGGGGTTAGA       GCAGCTGCTGGAGGGCCTACAGCACAATCCCCCGCTCAGCTGGCTGGTAGGGCCCTTCGCCTTGCCCG       CTGGCGGGCAG TGA   AGGGGGCGGCCGCGGAGCCT                                           NOV32g, CG55906-03                       Sequence   SEQ ID NO: 806   223 aa   MW at 23431.8kD                     MSAPDEGRRDPPKPKGKTLGSFFGSLPGFSSARNLVANAHSSARARPAADPTGAPAAEAAQPQAQVAA           HPEQTAPWTEKELQPSEKIEKAQQAPEGQPRLDQGSGASAEDAAVQEERDAGVLSRVCGLLRQLHTAY       SGLVSSLQGLPAELQQPVGRARHSLCELYGIVASAGSVEELPAERLVQSREGVHQAWQGLEQLLEGLQ       HNPPLSWLVGPFALPAGGQ                                     NOV32h,                   SNP13382505 of   SEQ ID NO: 807   3839 bp       CG55906-01,   ORF Start: ATG at 131   ORF Stop: TAG at 3806       DNA Sequence   SNP Pos: 3393   SNP Change: C to T                       GTGAGGCCAGGCCTGCAGGTGGGTGTCGGGCTGCTCAGGCTTTCAGTGGGGAGTGGGTGTGGGATGGC               AGGCTAGGGAACCCCCATTCACGCACCTTCTCTGCCCCCTTCCAGCTTCTCACGTTCTCACT   ATG TCT       GCTCCAGACGAAGGGAGACGGGATCCCCCCAAACCGAAGGGCAAGCCCCCCGCCCCCATGCAGACCCT       GGGCAGCTTCTTTGGGTCCCTGCCTGGCTTCAGCTCTGCCCGGAACCTGGTGGCCAACGCACATAGCT       CGGTCGGGGCCAAAGACCTGGTGTGTTCCAAGATGTCCAGGGCCAAGGATGCCGTGTCCTCCGGGGTG       GCCAGCGTGGTGGACGTGGCTAAGGGAGTGGTCCAGGGAGGCCTGGACACCACTCGGTCTGCACTTAC       GGGCACCAAGGAGGTGGTGTCCAGCGGGGTCACAGGGGCCATGGACATGGCTAAGGGGGCCGTCCAAG       GGGGTCTGGACACCTCGAAGGCTGTCCTCACCGGCACCAAGGACACGGTGTCCACTGGGCTCACGGGG       GCAGTGAATGTGGCCAAAGGGACCGTACAGGCCGGTGTGGACACCACCAAGACTGTGCTGACCGGCAC       CAAAGACACAGTGACTACTGGGGTCATGGGGGCAGTGAACTTGGCCAAAGGGACTGTCCAGACTGGCG       TGGAAACCTCCAAGGCTGTGCTGACCGGCACCAAAGATGCTGTGTCCACTGGGCTCACAGGGGCAGTG       AATGTGGCCAGAGGAAGCATTCAGACCGGTGTGGACACCAGTAAGACTGTCCTAACAGGTACCAAGGA       CACCGTCTGTAGTGGGGTGACTGGTGCCATGAATGTGGCCAAAGGAACCATCCAGACCGGCGTGGACA       CCAGTAAGACTGTCCTAACAGGTACCAAGGACACCGTCTGTAGTGGGGTGACTGGTGCCATGAATGTG       GCCAAAGGAACCATCCAGACCGGCGTGGACACCAGTAAGACTGTCCTAACAGGTACCAAGGACACCGT       CTGTAGTGGGGTGACTGGTGCCATGAATGTGGCCAAAGGAACCATCCAGACCGGCGTGGACACCACCA       AGACTGTCCTAACTGGCACCAAGAACACTGTCTGCAGTGGGGTGACCGGTGCCGTGAACTTGGCCAAA       GAGGCCATCCAGGGGGGCCTGGATACCACCAAGTCTATGGTCATGGGTACGAAAGACACGATGTCCAC       GGGACTCACAGGGGCAGCGAATGTGGCCAAGGGGGCCATGCAAACTGGGCTGAACACAACCCAAAATA       TCGCAACAGGTACAAAGGACACCGTCTGCAGTGGGGTGACTGGTGCCATGAATTTGGCCAGAGGAACC       ATCCAGACAGGCGTGGACACCACCAAGATCGTTCTAACTGGTACCAAGGACACTGTCTGCAGTGGGGT       CACCGGTGCTGCGAATGTGGCCAAAGGGGCCGTCCAGGGCGGCCTGGACACTACAAAGTCTGTCCTGA       CTGGCACTAAAGATGCTGTGTCCACTGGGCTCACAGGGGCTGTGAACGTGGCCAAAGGGACCGTCCAG       ACCGGCGTAGACACCACCAAGACTGTCCTAACCGGCACCAAGGACACCGTCTGCAGTGGGGTGACCAG       TGCTGTGAACGTGGCCAAAGGGGCCGTCCAGGGGGGCCTGGACACCACCAAGTCTGTGGTCATAGGTA       CAAAAGACACGATGTCCACTGGGCTCACGGGGGCAGCGAATGTGGCCAAGGGGGCTGTCCAGACAGGT       GTAGACACAGCCAAGACCGTGCTGACCGGCACCAAGGACACAGTGACTACTGGGCTCGTGGGGGCAGT       GAATGTCGCCAAAGGGACCGTCCAGACAGGCATGGACACCACCAAAACTGTCCTAACCGGTACCAAGG       ACGACCCAAAATATCGCGACAGGTACAAAGAACACCTTTGGCAGTGGGGTGACCAGTGCTGTGAATGT       GGCCAAAGGGGCTGCCCAGACAGGTGTAGACACGGCCAAGACCGTGCTGACCGGCACCAAGGACACAG       TCACTACTGGGCTCATGGGGGCAGTGAATGTCGCCAAAGGGACTGTCCAGACCAGTGTGGACACCACC       AAGACTGTCCTAACTGGTACCAAGGACACCGTCTGCAGTGGGGTGACCGGTGCTGCGAATGTGGCCAA       AGGGGCCATCCAAGGGGGCCTGGACACTACAAAGTCTGTCCTGACTGGCACTAAAGATGCTGTGTCCA       CTGGGCTCACAGGGGCTGTGAAGTTGGCCAAAGGGACTGTCCAGACCGGCATGGACACCACCAAGACT       GTGTTAACTGGTACCAAGGATGCTGTGTGCAGTGGGGTGACCGGTGCTGCGAATGTGGCCAAGGGGGC       CGTCCAGATGGGTGTAGACACGGCCAAGACCGTGCTGACCGGTACCAAGGACACTGTCTGCAGTGGGG       TCACCGGTGCTGCGAACGTGGCCAAGGGTGCTGTGCAAACTGGGCTGAAAACGACCCAAAATATCGCA       ACAGGTACAAAGAACACCCTTGGCAGTGGGGTGACCGGTGCTGCGAAAGTGGCCAAAGGGGCCGTCCA       GGGGGGCCTGGACACTACAAAGTCTGTCCTGACTGGCACTAAAGATGCCGTGTCCACTGGGCTCACAG       GGGCTGTGAACTTGGCCAAAGGGACTGTCCAGACCGGCGTGGACACCAGCAAGACTGTCCTGACCGGT       ACCAAGGACACCGTCTGCAGTGGAGTCACTGGTGCCGTAAATGTGGCCAAAGGGACCGTCCAGACAGG       TGTGGACACAGCCAAGACGGTGCTGAGTGGCGCTAAGGATGCAGTGACTACTGGAGTCACGGGGGCAG       TGAATGTGGCCAAAGGAACCGTGCAGACCGGCGTGGACGCCTCCAAGGCTGTGCTTATGGGTACCAAG       GACACTGTCTTCAGTGGGGTTACCGGTGCCATGAGCATGGCCAAAGGGGCCGTCCAGGGGGGCCTGGA       CACCACC)AGACAGTGCTGACCGGAACCAAAGACGCAGTGTCCGCTGGGCTCATGGGGTCAGGGAACG       TGGCGACAGGGGCCACCCACACTGGCCTCAGCACCTTCCAGAACTGGTTACCTAGTACCCCCGCCACC       TCCTGGGGTGGACTCACCAGTTCCAGGACCACAGCTCAGCTGGCTGCCTCCCAGCCTGGGCCAAAGGT       GCTGTCGGCGGAACAGGGGAGCTACTTCGTTCGTTTAGGTGACCTGGGTCCCAGCTTCCGCCAGCGGG       CATTTGAACACGCGGTGAGCCACCTGCAGCACGGCCAGTTCCAAGCCAGGGACACTCTGG   T   CCAGCTC       CAGGACTGCTTCAGGCTGATTGAAAAGGCCCAGCAGGCTCCAGAAGGGCAGCCACGTCTGGACCAGGG       CTCAGGTGCCAGTGCGGAGGACGCTGCTGTCCAGGAGAGGGTCTGCGGCCTTCTCCGGCAGCTGCACA       CGGCCTACAGTGGCCTGGTCTCCAGCCTCCAGGGCCTGCCCGCCGAGCTCCAGCAGCCAGTGGGGCGG       GCGCGGCACAGCCTCTGTGAGCTCTATGGCATCGTGGCCTCAGCTGGCTCTGTAGAGGAGCTGCCCGC       AGAGCGGCTGGTGCAGAGCCGCGAGGGTGTGCACCAGGCTTGGCAGGGGTTAGAGCAGCTGCTGGAGG       GCCTACAGCACAATCCCCCGCTCAGCTGGCTGGTAGGGCCCTTCGCCTTGCCCGCTGGCGGGCAG TAG           CTGTAGGAGCCTGCAGGCCCGGCGCGGGGTC                                           NOV32h,                       SNP13382505 of       CG55906-01,   SEQ ID NO: 808       MW at 120859.1kD       Protein Sequence   SNP Pos: 1088   1225 aa   SNP Change: Ala to Val                     MSAPDEGRRDPPKPKGKPPAPMQTLGSFFGSLPGFSSARNLVANAHSSVGAKDLVCSKMSRAKDAVSS           GVASVVDVAKGVVQGGLDTTRSALTGTKEVVSSGVTGAMDMAKGAVQGGLDTSKAVLTGTKDTVSTGL       TGAVNVAKGTVQAGVDTTKTVLTGTKDTVTTGVMGAVNLAKGTVQTGVETSKAVLTGTKDAVSTGLTG       AVNVARGSIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAM       NVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGANNVAKGTIQTGVDTTKTVLTGTKNTVCSGVTGAVNL       AKEAIQGGLDTTKSMVMGTKDTMSTGLTGAANVAKGAMQTGLNTTQNIATGTKDTVCSGVTGAMNLAR       GTIQTGVDTTKIVLTGTKDTVCSGVTGAANVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNVAKGT       VQTGVDTTKTVLTGTKDTVCSGVTSAVNVAKGAVQGGLDTTKSVVIGTKDTMSTGLTGAANVAKGAVQ       TGVDTAIKTVLTGTKDTVTTGLVGAVNVAKGTVQTGDTTKTVLTGTKDTIYSGVTSAVNVAKGAVQTG       LKTTQNIATGTKNTFGSGVTSAVNVAXGAAQTGVDTAKTVLTGTKDTVTTGLMGAVNVAKGTVQTSVD       TTKTVLTGTKDTVCSGVTGAANVAKGAQGGLDTTKSVLTGTKDAVSTGLTGAVKLAIKGTVQTGMDTT       KTVLTGTKDAVCSGVTGAANVAKGAVQMGVDTAKTVLTGTKDTVCSGVTGAANVAKGAVQTGLKTTQN       IATGTKNTLGSGVTGAAKVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNLAKGTVQTGVDTSKTVL       TGTKDTVCSGVTGAVNVAKGTVQTGVDTAKTVLSGAXDAVTTGVTGAVNVAKGTVQTGVDASKAVLMG       TKDTVFSGVTGAMSMAKGAVQGGLDTTKTVLTGTKDAVSAGLMGSGNVATGATHTGLSTFQNWLPSTP       ATSWGGLTSSRTTAQLAASQPGPKVLSAEQGSYFVRLGDLGPSFRQRAFEHAVSHLQHGQFQARDTLV       QLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDAAVQERVCGLLRQLHTAYSGLVSSLQGLPAELQQPV       GRARHSLCELYGIVASAGSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGG                                     SNP1 3382504 of   SEQ ID NO: 809   3839 bp           G55906-01,   ORF Start: ATG at 131   ORF Stop: TAG at 3806       DNA Sequence   SNP Pos: 3409   SNP Change: C to T                       GTGAGGCCAGGCCTGCAGGTGGGTGTCGGGCTGCTCAGGCTTTCAGTGGGGAGTGGGTGTGGGATCGG               AGGCTAGGGAACCCCCATTCACGCACCTTCTCTGCCCCCTTCCAGCTTCTCACGTTCTCACT   ATG TCT       GCTCCAGACGAAGGGAGACGGGATCCCCCCAAACCGAAGGGCAAGCCCCCCGCCCCCATGCAGACCCT       GGGCAGCTTCTTTGGGTCCCTGCCTGGCTTCAGCTCTGCCCGGAACCTGGTGGCCAACGCACATAGCT       CGGTCGGGGCCAAAGACCTGGTGTGTTCCAAGATGTCCAGGGCCAAGGATGCCGTGTCCTCCGGGGTG       GCCAGCGTGGTGGACGTGGCTAAGGGAGTGGTCCAGGGAGGCCTGGACACCACTCGGTCTGCACTTAC       GGGCACCAAGGAGGTGGTGTCCAGCGGGGTCACAGGGGCCATGGACATGGCTAAGGGGGCCGTCCAAG       GGGGTCTGGACACCTCGAAGGCTGTCCTCACCGGCACCAAGGACACGGTGTCCACTGGGCTCACGGGG       GCAGTGAATGTGGCCAAAGGGACCGTACAGGCCGGTGTGGACACCACCAAGACTGTGCTGACCGGCAC       CAAAGACACAGTGACTACTGGGGTCATGGGGGCAGTGAACTTGGCCAAAGGGACTGTCCAGACTGGCG       TGGAAACCTCCAAGGCTGTGCTGACCGGCACCAAAGATGCTGTGTCCACTGGGCTCACAGGGGCAGTG       AATGTGGCCAGAGGAAGCATTCAGACCGGTGTGGACACCAGTAAGACTGTCCTAACAGGTACCAAGGA       CACCGTCTGTAGTGGGGTGACTGGTGCCATGAATGTGGCCAAAGGAACCATCCAGACCGGCGTGGACA       CCAGTAAGACTGTCCTAACAGGTACCAAGGACACCGTCTGTAGTGGGGTGACTGGTGCCATGAATGTG       GCCAAAGGAACCATCCAGACCGGCGTGGACACCAGTAAGACTGTCCTAACAGGTACCAAGGACACCGT       CTGTAGTGGGGTGACTGGTGCCATGAATGTGGCCAAAGGAACCATCCAGACCGGCGTGGACACCACCA       AGACTGTCCTAACTGGCACCAAGAACACTGTCTGCAGTGGGGTGACCGGTGCCGTGAACTTGGCCAAA       GAGGCCATCCAGGGGGGCCTGGATACCACCAAGTCTATGGTCATGGGTACGAAAGACACGATGTCCAC       TGGGCTCACAGGGGCAGCGAATGTGGCCAAGGGGGCCATGCAAACTGGGCTGAACACAACCCAAAATA       TCGCAACAGGTACAAAGGACACCGTCTGCAGTGGGGTGACTGGTGCCATGAATTTGGCCAGAGGAACC       ATCCAGACAGGCGTGGACACCACCAAGATCGTTCTAACTGGTACCAAGGACACTGTCTGCAGTGGGGT       CACCGGTGCTGCGAATGTGGCCAAAGGGGCCGTCCAGGGCGGCCTGGACACTACAAAGTCTGTCCTGA       CTGGCACTAAAGATGCTGTGTCCACTGGGCTCACAGGGGCTGTGAACGTGGCCAAAGGGACCGTCCAG       ACCGGCGTAGACACCACCAAGACTGTCCTAACCGGCACCAAGGACACCGTCTGCAGTGGGGTGACCAG       TGCTGTGAACGTGGCCAAAGGGGCCGTCCAGGGGGGCCTGGACACCACCAAGTCTGTGGTCATAGGTA       CAAAAGACACGATGTCCACTGGGCTCACGGGGGCAGCGAATGTGGCCAAGGGGGCTGTCCAGACAGGT       GTAGACACAGCCAAGACCGTGCTGACCGGCACCAAGGACACAGTGACTACTGGGCTCGTGGGGGCAGT       GAATGTCGCCAAAGGGACCGTCCAGACAGGCATGGACACCACCAAAACTGTCCTAACCGGTACCAAGG       ACACCATCTACAGTGGGGTCACCAGTGCCGTGAACGTGGCCAAGGGGGCTGTGCAAACTGGGCTGAAA       ACGACCCAAAATATCGCGACAGGTACAAAGAACACCTTTGGCAGTGGGGTGACCAGTGCTGTGAATGT       GGCCAAAGGGGCTGCCCAGACAGGTGTAGACACGGCCAAGACCGTGCTGACCGGCACCAAGGACACAG       TCACTACTGGGCTCATGGGGGCAGTGAATGTCGCCAAAGGGACTGTCCAGACCAGTGTGGACACCACC       AAGACTGTCCTAACTGGTACCAAGGACACCGTCTGCAGTGGGGTGACCGGTGCTGCGAATGTGGCCAA       AGGGGCCATCCAAGGGGGCCTGGACACTACAAAGTCTGTCCTGACTGGCACTAAAGATGCTGTGTCCA       CTGGGCTCACAGGGGCTGTGAAGTTGGCCAAAGGGACTGTCCAGACCGGCATGGACACCACCAAGACT       GTGTTAACTGGTACCAAGGATGCTGTGTGCAGTGGGGTGACCGGTGCTGCGAATGTGGCCAAGGGGGC       CGTCCAGATGGGTGTAGACACGGCCAAGACCGTGCTGACCGGTACCAAGGACACTGTCTGCAGTGGGG       TCACCGGTGCTGCGAACGTGGCCAAGGGTGCTGTGCAAACTGGGCTGAAAACGACCCAAAATATCGCA       ACAGGTACAAAGAACACCCTTGGCAGTGGGGTGACCGGTGCTGCGAAAGTGGCCAAAGGGGCCGTCCA       GGGGGGCCTGGACACTACAAAGTCTGTCCTGACTGGCACTAAAGATGCCGTGTCCACTGGGCTCACAG       GGGCTGTGAACTTGGCCAAAGGGACTGTCCAGACCGGCGTGGACACCAGCAAGACTGTCCTGACCAAT       ACCAAGGACACCGTCTGCAGTGGAGTCACTGGTGCCGTAAATGTGGCCAAAGGGACCGTCCAGACAGG       TGTGGACACAGCCAAGACGGTGCTGAGTGGCGCTAAGGATGCAGTGACTACTGGAGTCACGGGGGCAG       TGAATGTGGCCAAAGGAACCGTGCAGACCGGCGTGGACGCCTCCAAGGCTGTGCTTATGGGTACCAAG       GACACTGTCTTCAGTGGGGTTACCGGTGCCATGAGCATGGCCAAAGGGGCCGTCCAGGGGGGCCTGGA       CACCACCAAGACAGTGCTGACCGGAACCAAAGACGCAGTGTCCGCTGGGCTCATGGGGTCAGGGAACG       TGGCGACAGGGGCCACCCACACTGGCCTCAGCACCTTCCAGAACTGGTTACCTAGTACCCCCGCCACC       TCCTGGGGTGGACTCACCAGTTCCAGGACCACAGCTCAGCTGGCTGCCTCCCAGCCTGGGCCAAAGGT       GCTGTCGGCGGAACAGGGGAGCTACTTCGTTCGTTTAGGTGACCTGGGTCCCAGCTTCCGCCAGCGGG       CATTTGAACACGCGGTGAGCCACCTGCAGCACGGCCAGTTCCAAGCCAGGGACACTCTGGCCCAGCTC       CAGGACTG   T   TTCAGGCTGATTGAAAAGGCCCAGCAGGCTCCAGAAGGGCAGCCACGTCTGGACCAGGG       CTCAGGTGCCAGTGCGGAGGACGCTGCTGTCCAGGAGAGGGTCTGCGGCCTTCTCCGGCAGCTGCACA       CGGCCTACAGTGGCCTGGTCTCCAGCCTCCAGGGCCTGCCCGCCGAGCTCCAGCAGCCAGTGGGGCGG       GCGCGGCACAGCCTCTGTGAGCTCTATGGCATCGTGGCCTCAGCTGGCTCTGTAGAGGAGCTGCCCGC       AGAGCGGCTGGTGCAGAGCCGCGAGGGTGTGCACCAGGCTTGGCAGGGGTTAGAGCAGCTGCTGGAGG       GCCTACAGCACAATCCCCCGCTCAGCTGGCTGGTAGGGCCCTTCGCCTTGCCCGCTGGCGGGCAG TAG           CTGTAGGAGCCTGCAGGCCCGGCGCGGGGTC                                           NOV32i,                       SNP13382504 of       CG559O6-01,   SEQ ID NO: 810       MW at 120831.1kD       Protein Sequence   SNP Pos: 1093   1225 aa   SNP Change: Cys to Cys                     MSAPDEGRRDPPKPKGKPPAPMQTLGSFFGSLPGFSSAENLVANAHSSVGAKDLVCSKMSRAKDAVSS           GVASVVDVAKGVVQGGLDTTRSALTGTKEVVSSGVTGAMDMAKGAVQGGLDTSKAVLTGTKDTVSTGL       TGAVNVAKGTVQAGVDTTKTVLTGTKDTVTTGVMGAVNLAKGTVQTGVETSKAVLTGTKDAVSTGLTG       AVNVARGSIQTGVDTSKTVLTGTKDTVCSGVTGANNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAM       NVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGANNVAXGTIQTGVDTTKTVLTGTKNTVCSGVTGAVNL       AKEAIQGGLDTTKSMVMGTKDTMSTGLTGAANVAKGAMQTGLNTTQNIATGTKDTVCSGVTGAMNTAR       GTIQTGVDTTKIVLTGTKDTVCSGVTGAANVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNVAKGT       VQTGVDTTKTVLTGTKDTVCSGVTSAVNVAKGAVQGGLDTTKSVVIGTKDTMSTGLTGAANVAKGAVQ       TGVDTAKTVLTGTKDTVTTGLVGAVNVAKGTVQTGMDTTKTVLTGTKDTIYSGVTSAVNVAKGAVQTG       LKTTQNIATGTKNTFGSGVTSAVVAKGAAQTGVDTAKTXTLTGTKDTVTTGLMGAVNVAKGTVQTSVD       TTKTVLTGTKDTVCSGVTGAANVAKGAIQGGLDTTKSVLTGTKDAVSTGLTGAVKLAKGTVQTGMDTT       KTVLTGTKDAVCSGVTGAAAVAKGAVQMGVDTAKTVLTGTKDTVCSGVTGAAINAKGAVQTGLKTTQN       IATGTKNTLGSGVTGAAKVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNLAKGTVQTGVDTSKTVL       TGTKDTVCSGVTGAVNVAKGTVQTGVDTAKTVLSGAKDAVTTGVTGAVNVAKGTVQTGVDASKAVLMG       TKDTVFSGVTGAMSMAKGAVQGGLDTTKTVLTGTKDAVSAGLMGSGNVATGATHTGLSTFQNWLPSTP       ATSWGGLTSSRTTAQLAASQPGPKVLSAEQGSYFVRLGDLGPSFRQRAFEHAVSHLQHGQFQARDTLA       QLQD   C   FRLIEKAQQAPEGQPRLDQGSGASAEDAAVQERVCGLLRQLHTAYSGLVSSLQGLPAELQQPV       GRARHSLCELYGIVASAGSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGG       Q                                     NOV32j,                   SNP13376440 of   SEQ ID NO: 811   3839 bp       CG55906-01,   ORF Start: ATG at 131   ORF Stop: TAG at 3806       DNA Sequence SNP Pos: 3681   SNP Change: T to C                       GTGAGGCCAGGCCTGCAGGTGGGTGTCGGGCTGCTCAGGCTTTCAGTGGGGAGTGGGTGTGGGATGGG               AGGCTAGGGAACCCCCATTCACGCACCTTCTCTGCCCCCTTCCAGCTTCTCACGTTCTCACT   ATG TCT       GCTCCAGACGAAGGGAGACGGGATCCCCCCAAACCGAAGGGCAAGCCCCCCGCCCCCATGCAGACCCT       GGGCAGCTTCTTTGGGTCCCTGCCTGGCTTCAGCTCTGCCCGGAACCTGGTGGCCAACGCACATAGCT       CGGTCGGGGCCAAAGACCTGGTGTGTTCCAAGATGTCCAGGGCCAAGGATGCCGTGTCCTCCGGGGTG       GCCAGCGTGGTGGACGTGGCTAAGGGAGTGGTCCAGGGAGGCCTGGACACCACTCGGTCTGCACTTAC       GGGCACCAAGGAGGTGGTGTCCAGCGGGGTCACAGGGGCCATGGACATGGCTAAGGGGGCCGTCCAAG       GGGGTCTGGACACCTCGAAGGCTGTCCTCACCGGCACCAAGGACACGGTGTCCACTGGGCTCACGGGG       GCAGTGAATGTGGCCAAAGGGACCGTACAGGCCGGTGTGGACACCACCAAGACTGTGCTGACCGGCAC       CAAAGACACAGTGACTACTGGGGTCATGGGGGCAGTGAACTTGGCCAAAGGGACTGTCCAGACTGGCG       TGGAAACCTCCAAGGCTGTGCTGACCGGCACCAAAGATGCTGTGTCCACTGGGCTCACAGGGGCAGTG       AATGTGGCCAGAGGAAGCATTCAGACCGGTGTGGACACCAGTAAGACTGTCCTAACAGGTACCAAGGA       CACCGTCTGTAGTGGGGTGACTGGTGCCATGAATGTGGCCAAAGGAACCATCCAGACCGGCGTGGACA       CCAGTAAGACTGTCCTAACAGGTACCAAGGACACCGTCTGTAGTGGGGTGACTGGTGCCATGAATGTG       GCCAAAGGAACCATCCAGACCGGCGTGGACACCAGTAAGACTGTCCTAACAGGTACCAAGGACACCGT       CTGTAGTGGGGTGACTGGTGCCATGAATGTGGCCAAAGGAACCATCCAGACCGGCGTGGACACCACCA       AGACTGTCCTAACTGGCACCAAGAACACTGTCTGCAGTGGGGTGACCGGTGCCGTGAACTTGGCCAAA       GAGGCCATCCAGGGGGGCCTGGATACCACCAAGTCTATGGTCATGGGTACGAAAGACACGATGTCCAC       TGGGCTCACAGGGGCAGCGAATGTGGCCAAGGGGGCCATGCAAACTGGGCTGAACACAACCCAAAATA       TCGCAACAGGTACAAAGGACACCGTCTGCAGTGGGGTGACTGGTGCCATGAATTTGGCCAGAGGAACC       ATCCAGACAGGCGTGGACACCACCAAGATCGTTCTAACTGGTACCAAGGACACTGTCTGCAGTGGGGT       CACCGGTGCTGCGAATGTGGCCAAAGGGGCCGTCCAGGGCGGCCTGGACACTACAAAGTCTGTCCTGA       CTGGCACTAAAGATGCTGTGTCCACTGGGCTCACAGGGGCTGTGAACGTGGCCAAAGGGACCGTCCAG       ACCGGCGTAGACACCACCAAGACTGTCCTAACCGGCACCAAGGACACCGTCTGCAGTGGGGTGACCAG       TGCTGTGAACGTGGCCAAAGGGGCCGTCCAGGGGGGCCTGGACACCACCAAGTCTGTGGTCATAGGTA       CAAAAGACACGATGTCCACTGGGCTCACGGGGGCAGCGAATGTGGCCAAGGGGGCTGTCCAGACAGGT       GTAGACACAGCCAAGACCGTGCTGACCGGCACCAAGGACACAGTGACTACTGGGCTCGTGGGGGCAGT       GAATGTCGCCAAAGGGACCGTCCAGACAGGCATGGACACCACCAAAACTGTCCTAACCGGTACCAAGG       ACACCATCTACAGTGGGGTCACCAGTGCCGTGAACGTGGCCAAGGGGGCTGTGCAAACTGGGCTGAAA       ACGACCCAAAATATCGCGACAGGTACAAAGAACACCTTTGGCAGTGGGGTGACCAGTGCTGTGAATGT       GGCCAAAGGGGCTGCCCAGACAGGTGTAGACACGGCCAAGACCGTGCTGACCGGCACCAAGGACACAG       TCACTACTGGGCTCATGGGGGCAGTGAATGTCGCCAAAGGGACTGTCCAGACCAGTGTGGACACCACC       ATGACTGTCCTAACTGGTACCAAGGACACCGTCTGCAGTGGGGTGACCGGTGCTGCGAATGTGGCCAA       AGGGGCCATCCAAGGGGGCCTGGACACTACAAAGTCTGTCCTGACTGGCACTAAAGATGCTGTGTCCA       CTGGGCTCACAGGGGCTGTGAAGTTGGCCAAAGGGACTGTCCAGACCGGCATGGACACCACCAAGACT       GTGTTAACTGGTACCAAGGATGCTGTGTGCAGTGGGGTGACCGGTGCTGCGAATGTGGCCAAGGGGGC       CGTCCAGATGGGTGTAGACACGGCCAAGACCGTGCTGACCGGTACCAAGGACACTGTCTGCAGTGGGG       TCACCGGTGCTGCGAACGTGGCCAAGGGTGCTGTGCAAACTGGGCTGAAAACGACCCAAAATATCGCA       ACAGGTACAAAGAACACCCTTGGCAGTGGGGTGACCGGTGCTGCGAAAGTGGCCAAAGGGGCCGTCCA       GGGGGGCCTGGACACTACAAAGTCTGTCCTGACTGGCACTAAAGATGCCGTGTCCACTGGGCTCACAG       GGGCTGTGAACTTGGCCAAAGGGACTGTCCAGACCGGCGTGGACACCAGCAAGACTGTCCTGACCGGT       ACCAAGGACACCGTCTGCAGTGGAGTCACTGGTGCCGTAAATGTGGCCAAAGGGACCGTCCAGACAGG       TGTGGACACAGCCAAGACGGTGCTGAGTGGCGCTAAGGATGCAGTGACTACTGGAGTCACGGGGGCAG       TGAATGTGGCCAAAGGAACCGTGCAGACCGGCGTGGACGCCTCCAAGGCTGTGCTTATGGGTACCAAG       GACACTGTCTTCAGTGGGGTTACCGGTGCCATGAGCATGGCCAAAGGGGCCGTCCAGGGGGGCCTGGA       CACCACCAAGACAGTGCTGACCGGAACCAAAGACGCAGTGTCCGCTGGGCTCATGGGGTCAGGGAACG       TGGCGACAGGGGCCACCCACACTGGCCTCAGCACCTTCCAGAACTGGTTACCTAGTACCCCCGCCACC       TCCTGGGGTGGACTCACCAGTTCCAGGACCACAGCTCAGCTGGCTGCCTCCCAGCCTGGGCCAAAGGT       GCTGTCGGCGGAACAGGGGAGCTACTTCGTTCGTTTAGGTGACCTGGGTCCCAGCTTCCGCCAGCGGG       CATTTGAACACGCGGTGAGCCACCTGCAGCACGGCCAGTTCCAAGCCAGGGACACTCTGGCCCAGCTC       CAGGACTG   T   TTCAGGCTGATTGAAAAGGCCCAGCAGGCTCCAGAAGGGCAGCCACGTCTGGACCAGGG       CTCAGGTGCCAGTGCGGAGGACGCTGCTGTCCAGGAGAGGGTCTGCGGCCTTCTCCGGCAGCTGCACA       CGGCCTACAGTGGCCTGGTCTCCAGCCTCCAGGGCCTGCCCGCCGAGCTCCAGCAGCCAGTGGGGCGG       GCGCGGCACAGCCTCTGTGAGCTCTATGGCATCGTGGCCTCAGCTGGCTCTGTAGAGGAGCTGCCCGC       AGAGCGGCCGGTGCAGAGCCGCGAGGGTGTGCACCAGGCTTGGCAGGGGTTAGAGCAGCTGCTGGAGG       GCCTACAGCACAATCCCCCGCTCAGCTGGCTGGTAGGGCCCTTCGCCTTGCCCGCTGGCGGGCAG TAG           CTGTAGGAGCCTGCAGGCCCGGCGCGGGGTC                                           NOV32j,                       SNP13376440 of       CG55906-01,   SEQ ID NO: 812       MW at 120815.0kD       Protein Sequence   SNP Pos: 1184   1225 aa   SNP Change: Leu to Pro                     MSAPDEGRPDPPKPKGKPPAPMQTLGSFFGSLPGFSSARNLVANAHSSVGAKDLVCSKMSRAKDAVSS           GVASVVDVAXGVVQGGLDTTRSALTGTKEVVSSGVTGANDMAKGAVQGGLDTSKAVLTGTKDTVSTGL       TGAVNVAKGTVQAGVDTTKTVLTGTKDTVTTGVMGAVNLAKGTVQTGVETSKAVLTGTKDAVSTGLTG       AVNVARGSIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAM       NVAKGTIQTGVDTSKTVLTGTKDTTCSGVTGAMNVAKGTIQTGVDTTKTVLTGTKNTVCSGVTGAVNL       AKEAIQGGLDTTKSMVMGTKDTMSTGLTGAANVAKGAMQTGLNTTQNIATGTKDTVCSGVTGANNLAR       GTIQTGVDTTKIVLTGTKDTVCSGVTGAANVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNVAKGT       VQTGVDTTKTVLTGTKDTVCSGVTSAVNVAKGAVQGGLDTTKSVVIGTKDTMSTGLTGAANVAXGAVQ       TGVDTAKTVLTGTKDTVTTGLVGAVNVAKGTVQTGMDTTKTVLTGTKDTIYSGVTSAVNVAKGAVQTG       LKTTQNIATGTKNTFGSGVTSAVNVAKGAAQTGVDTAKTVLTGTKDTVTTGLMGAVNVAKGTVQTSVD       TTKTVLTGTKDTVCSGVTGAANVAKGATQGGLDTTKSVLTGTKDAVSTGLTGAVKLAKGTVQTGMDTT       KTVLTGTKDAVCSGVTGAANVAKGAVQMGVDTAKTVLTGTKDTVCSGVTGAANVAKGAVQTGLKTTQN       IATGTKNTLGSGVTGAAKVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNLAKGTVQTGVDTSKTVL       TGTKDTVCSGVTGAVNVAKGTVQTGVDTAKTVLSGAKDAVTTGVTGAVNVAKGTVQTGVDASKAVLMG       TKDTVFSGVTGAMSMAKGAVQGGLDTTKTVLTGTKDAVSAGLMGSGNVATGATHTGLSTFQNWLPSTP       ATSWGGLTSSRTTAQLAASQPGPKTLSAEQGSYFVRLGDLGPSFRQPAFEHAVSHLQHGQFQARDTLA       QLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDAAVQERVCGLLRQLHTAYSGLVSSLQGLPAELQQPV       GRARHSLCELYGIVASAGSVEELPAER   P   VQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGG       Q                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 32B.  
               TABLE 32B                       Comparison of the NOV32 protein sequences.                                                NOV32a   ------------------------------------------------------------   (SEQ ID NO:794)                   NOV32b   MSAPDEGRRDPPKPKGKTLGSFFGSLPGFNSARNLVANAHSSARARPAADPTGAPAAEAA   (SEQ ID NO:796)               NOV32c   ------------------------------------------------------------   (SEQ ID NO:798)               NOV32d   ------------------------------------------------------------   (SEQ ID NO:800)               NOV32e   ------------------------------------------------------------   (SEQ ID NO:802)               NOV32f   ------------------------------------------------------------   (SEQ ID NO:804)               NOV32g   ------------------------------------------------------------   (SEQ ID NO:806)               NOV32a   ------------------------------------------------------------               NOV32b   QPQAQVAAHPEQTAPWTEKELQPSEKQMVSGAKDLVCSKNSRAKDAVSSGVASVVDVAKG               NOV32c   ------------------------------------------------------------               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   ------------------------------------------------------------               NOV32b   VVQGGLDTTRSALTGTKEAVSSGVTGAMDMAKGAVQGGLDTSKAVLTGTKDTVSTGLTGA               NOV32c   ------------------------------------------------------------               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   ------------------------------------------------------------               NOV32b   VNVAKGTVQAGVDTTKTVLTGTKDTVTTGVMGAVNLAKGTVQTGVETSKAVLTGTKDAVS               NOV32c   ------------------------------------------------------------               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   ------------------------------------------------------------               NOV32b   TGLTGAVNVARGSIQTGVDTSKTVLTGTKDTVCSGVTSAMNVAKGTIQTGVDTSKTVLTG               NOV32c   ------------------------------------------------------------               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   ------------------------------------------------------------               NOV32b   TKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTT               NOV32c   ------------------------------------------------------------               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   ------------------------------------------------------------               NOV32b   KTVLTGTKNTVCSGVTGAVNLAKEAIQGGLDTTKSMVMGTKDTMSTGLTGAANVAKGAMQ               NOV32c   ------------------------------------------------------------               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   ------------------------------------------------------------               NOV32b   TGLNTTQNIATGTKDTVCSGVTGANNLARGTIQTGVDTTKIVLTGTKDTVCSGVTGAANV               NOV32c   ------------------------------------------------------------               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   ------------------------------------------------------------               NOV32b   AKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNVAKGTVQTGVDTTKTVLTGTKDTVCSGV               NOV32c   ------------------------------------------------------------               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   ------------------------------------------------------------               NOV32b   TSAVNVAKGAVQGGLDTTKSVVIGTKDTMSTGLTGAANVAKGAVQTGVDTAKTVLTGTKD               NOV32c   ------------------------------------------------------------               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   ------------------------------------------------------------               NOV32b   TVTTGLVGAVNVAKGTVQTGMDTTKTVLTGTKDTIYSGVTSAVNVAKGAVQTGLKTTQNI               NOV32c   ------------------------------------------------------------               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   ----------------------------------MSAPDEGRRDPPKPKGK------TLG               NOV32b   ATGTKNTFGSGVTGAVNVAKGAVQTGVDTAKTVLTGTKDTVTTGLMGAVNV------AKG               NOV32c   ----------------------------------MSAPDEGRPDPPKPKGKPPAPMQTLG               NOV32d   -------------------------------RSIMSAPDEGRRDPPKPKGK------TLG               NOV32e   ----------------------------------MSAPDEGRRDPPKPKGK------TLG               NOV32f   ---------------------------ARPPFTTMSAPDEGRPDPPKPKGK------TLG               NOV32g   ----------------------------------MSAPDEGRRDPPKPKGK------TLG               NOV32a   SFFGSLPGFSSARNLVANAHSS-----------ARARPAADPTGAPAAEAAQPQAQVAAH               NOV32b   TVQTSVDTTKTVLTGTKDTVCS-----------GVTGAANVAKGAVQTGVDTAKTVLTGT               NOV32c   SFFGSLPGFSSAPNLVANAHSSVGAKDLVCSKMSRAKDAVSSGVASVVDVAKGVVQGGLD               NOV32d   SFFGSLPGFSSARNLVANAHSS-----------ARARPAADPTGAPAAEAAQPQAQVAAH               NOV32e   SFFGSLPGFNSARNLVANAHSS-----------ARARPAADPTGAPAAEAAQPQAQVAAH               NOV32f   SFFGSLPGFSSARNLVANAHSS-----------ARARPAADPTGAPAAEAAQPQAQVAAH               NOV32g   SFFGSLPGFSSAPNLVANAHSS-----------ARARPAADPTGAPAAEAAQPQAQVAAH               NOV32a   PEQTAPWTEKELQPSEKQ--------MVSGAKDLVCSKMSRAKDAVSSGVASVVDVAKGV               NOV32b   KDTVCSGVTGAVNVAKG---------AVQTGLKTTQNIATGTKNTLGSGVTGAANVAKGA               NOV32c   TTRSALTGTKEVVSSGVTGAMDMAKGAVQGGLDTSKAVLTGTKDTVSTGLTGAVNVAKGT               NOV32d   PEQTAPWTEKELQPSEK---------MVSGAKDLVCSKMSRAYDAVSSGVASVVDVATGV               NOV32e   PEQTAPWTEKELQPSE--------------------------------------------               NOV32f   PEQTAPWTEKELQPSE--------------------------------------------               NOV32g   PEQTAPWTEKELQPSE--------------------------------------------               NOV32a   VQGGLDTTRSALTGTKEVVSSGVTGAMDMAKGAVQGGLDTSKAVLTGTKDTVSTGLTGAV               NOV32b   VQGGLDTTKSVLTGTKDAVSTGLTGAVNLAKGTVQTGMDTTKTVLTGTKDAVCSGVTGAA               NOV32c   VQAGVDTTKTVLTGTKDTVTTGVMGAVNLAXGTVQTGVETSKAVLTGTKDAVSTGLTGAV               NOV32d   VQGGLDTTRSALTGTKEAVSSGFTGAMDMAKGAVQGGLDTSKAVLTGTKDTVSTGLTGAV               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   NVAKGTVQAGVDTTKTVLTGTKDTVTTGVMGAVNLAKGTVQTGVETSKAVLTGTKDAVST               NOV32b   NVAKGAVQTGVDTAKTVLTGTKDTVTTGLMGAVNVAKGTVQTSVDTTKTVLTGTKDTVCS               NOV32c   NVARGSIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCS               NOV32d   NVAKGTVQAGVDTTKTVLTGTKDTVTTGVMGAVNLAKGTVQTGVETSKAVLTGTKDAVST               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   GLTGAVNVARGSIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGT               NOV32b   GVTGAANWAKGAVQGGLDTTKSVLTGTKDTVSTGLTGAVNLAKGTVQTGVDTSKTVLTGT               NOV32c   GVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTTKTVLTGT               NOV32d   GLTGAVNVARGSIQTGVDTSKTVLTGTKDTVCSGVTSAMNNAKGTIQTGVDTSKTVLTGT               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   KDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTTK               NOV32b   KDTVCSGVT---------------------------------------------------               NOV32c   KNTVCSGVTGAVNLAKEAIQGGLDTTKSMVMGTKDTMSTGLTGAANVAKGAMQTGLNTTQ               NOV32d   KDTVCSGVT---------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   TVLTGTKNTVCSGVTGAVNLAKEAIQGGLDTTKSMVMGTKDTMSTGLTGAANVAKGAMQT               NOV32b   ------------------------------------------------------------               NOV32c   NIATGTKDTVCSGVTGAMNLARGTIQTGVDTTKIVLTGTKDTVCSGVTGAANVAKGAVQG               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   GLNTTQNIATGTKDTVCSGVTGAMNLARGTIQTGVDTTKIVLTGTKDTVCSGVTGAANVA               NOV32b   ------------------------------------------------------------               NOV32c   G---LDTTKSVLTG----------------------------------------------               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   KGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNVAKGTVQTGVDTTKTVLTGTKDTVCSGVT               NOV32b   ------------------------------------------------------------               NOV32c   ------------------------------------------------------------               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   SAVNVAKGAVQGGLDTTKSVVIGTKDTMSTGLTGAANVAKGAVQTGVDTAKTVLTGTKDT               NOV32b   ------------------------------------------------------------               NOV32c   --------------------------------------------------------TKDA               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   VTTGLVGAVNVAKGTVQTGMDTTKTVLTGTKDTIYSGVTSAVNVAKGAVQTGLKTTQNIA               NOV32b   ------------------------------------------------------------               NOV32c   VSTGLTGAVNVAKGTVQTGVDTTKTVLTGTKDTVCSGVTSAVNVAKGAVQGGLDTTKSVV               NOV32d   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   TGTKNTFGSGVTSAVNVAKGAAQTGVDTAKTVLTGTKDTVTTGLMGAVNVAKGTVQTSVD               NOV32b   ------------------------------------------------------------               NOV32c   IGTKDTMSTGLTGAANVAKGAVQTGVDTAKTVLTGTKDTVTTGLVGAVNVAKGTVQTGMD               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   TTKTVLTGTKDTVCSGVTGAANVAKGAIQGGLDTTKSVLTGTKDAVSTGLTGAVKLAKGT               NOV32b   ------------------------------------------------------------               NOV32c   TTKTVLTGTKDTIYSGVTSAVNVAKGAVQTGLKTTQNIATGTKNTFGSGVTSAVNVAKGA               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   VQTGMDTTKTVLTGTKDAVCSGVTGAANVAKGAVQMGVDTAKTVLTGTKDTVCSGVTGAA               NOV32b   ------------------------------------------------------------               NOV32c   AQTGVDTAKTVLTGTKDTVTTGLMGAVNVAKGTVQTSVDTTKTVLTGTKDTVCSGVTGAA               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   NVAKGAVQTGLKTTQNTATGTKNTLGSGVTGAAKVAKGAVQGGLDTTKSVLTGTKDAVST               NOV32b   ------------------------------------------------------------               NOV32c   NVAKGAIQGGLDTTKSVLTGTKDAVSTGLTGAVKLAKGTVQTGMDTTKTVLTGTKDAVCS               NOV32d   ------------------------------------------------------------               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   GLTGAVNLAKGTVQTGVDTSKTVLTGTKDTVCSGVTGAVNVAKGTVQTGVDTAKTVLSGA               NOV32b   ------------------------------------GAVNVAKGTVQTGVDTAKTVLSGA               NOV32c   GVTGAANVAKGAVQMGVDTAKTVLTGTKDTVCSGVTGAANVAKGAVQTGLKTTQNIATGT               NOV32d   ------------------------------------GAVNVAKGTVQTGVDTAKTVLSGA               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   KDAVTTGVTGAVNVAKGTVQTGVDASKAVLMGTKDTVFSGVTGAMSMAKGAVQGGLDTTK               NOV32b   KDAVTTGVTGAVNVAKGTVQTGVDASKAVLMGTKDTVFSGVTGAMSMAKGAVQGGLDTTK               NOV32c   KNTLGSGVTGAAKVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNLAKGTVQTGVDTSK               NOV32d   KDAVTTGVTGAVNVAKGTVQTGVDASKAVLMGTKDTVFSGVTGAMSMAKGAVQGGLDTTK               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32a   TVLTGTKDAVSAGLMGSGNVATGATHTGLSTFQNWLPSTPATSWGGLTSSRTTDNGGEQT               NOV32b   TVLTGTKDAVSAGLMGSGNVATGATHTGLSTFQNWLPSTPATSWGGLTSSRTTDNGGEQT               NOV32c   TVLTGTKDTVCSGVTGAVNVAKGTVQTGVDTAKTVLSGAKDAVTTGVTGAVNVAKGTVQT               NOV32d   TVLTGTKDAVSAGLMGSGNVATGATHTGLSTFQNWLPSTPATSWGGLTSSRTTDNGGEQT               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   ALSPQEAPFSGISTPPDVLSVGPEPAWEAAATTKGLATDVATFTQGAAPGREDTGL-LAT               NOV32b   ALSPQEAPFSGISTPPDVLSVGPEPAWEAAATTKGLATDVATFTQGAAPGREDTGL-LTT               NOV32c   GVDASKAVLMGTKDTVFSGVTGAMSMAKGAVQGGLDTTKTVLTGTKDAVSAGLMGSGNVA               NOV32d   ALSPQEAPFSGISTPPDVLSVGPEPAWEAAATTKGLATDVATFTQGAAPGREDTGL-LTT               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   THGPEEAPRLAMLQNELEGLGDTFHPNNAEEQAQLAASQPGPKVLSAEQGSYFVRLGDLG               NOV32b   THGPEEAPRLAMLQNELEGLGDIFHPNNAEEQAQLAASQPGPKVLSAEQGSYFVRLGDLG               NOV32c   TGATHTGLSTFQNWLPSTPATSWGGLTSSRTTAQLAASQPGPKVLSAEQGSYFVRLGDLG               NOV32d   THGPEEAPRLAMLQNELEGLGDIFHPMNAEEQAQLAASQPGPKVLSAEQGSYFVRLGDLG               NOV32e   ------------------------------------------------------------               NOV32f   ------------------------------------------------------------               NOV32g   ------------------------------------------------------------               NOV32a   PSFRQRAFEHAVSHLQHGQFQARDTLAQLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDA               NOV32b   PSFRQRAFEHAVSHLQHGQFQARDTLAQLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDA               NOV32c   PSFRQRAFEHAVSHLQHGQFQARDTLAQLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDA               NOV32d   PSFRQRAFEHAVSHLQHGQFQARDTLAQLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDA               NOV32e   ----------------------------------KIEKAQQAPEGQPRLDQGSGASAEDA               NOV32f   ----------------------------------KIEKAQQAPEGQPRLDQGSGASAEDA               NOV32g   ----------------------------------KIEKAQQAPEGQPRLDQGSGASAEDA               NOV32a   AVQEERDAGVLSRVCGLLRQLHTAYSGLVSSLQGLPAELQQPVGRARHSLCELYGIVASA               NOV32b   AVQEERDAGVLSRVCGLLRQLHTAYSGLVSSLQGLPAELQQPVGRARHSLCELYGIVASA               NOV32c   AVQER--------VCGLLRQLHTAYSGLVSSLQGLPAELQQPVGRARHSLCELYGIVASA               NOV32d   AVQEERDAGVLSRVCGLLRQLHTAYSGLVSSLQGLPAELQQPVGRARHSLCELYGIVASA               NOV32e   AVQEERDAGVLSRVCGLLRQLHTAYSGLVSSLRGLPAELQQPVGRARHSLCELYGIVASA               NOV32f   AVQEERDAGVLSRVCGLLRQLHTAYSGLVSSLQGLPAELQQPVGRARHSLCELYGIVASA               NOV32g   AVQEERDAGVLSRVCGLLRQLHTAYSGLVSSLQGLPAELQQPVGRARHSLCELYGIVASA               NOV32a   GSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGGQ--               NOV32b   GSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGGQ--               NOV32c   GSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGGQ--               NOV32d   GSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGGQLE               NOV32e   GSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGGQ--               NOV32f   GSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGGQ--               NOV32g   GSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGGQ--                  
 
      Further analysis of the NOV32a protein yielded the following properties shown in Table 32C.  
               TABLE 32C                       Protein Sequence Properties NOV32a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 10; pos. chg 2; neg. chg 3           H-region:   length 2; peak value 0.00           PSG score:   −4.40                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −4.76           possible cleavage site: between 32 and 33                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 0           number of TMS(s) . . . fixed                             PERIPHERAL   Likelihood = 1.43 (at 106)                         ALOM score: 1.43 (number of TMSs: 0)       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   6.59           Hyd Moment(95):   5.57   G content:   0           D/E content:   2   S/T content:   1                         Score: −6.74       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 8.6%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear           discrimination           Prediction: cytoplasmic           Reliability: 94.1       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         56.5%: cytoplasmic           26.1%: nuclear           13.0%: mitochondrial            4.3%: vesicles of secretory system                 &gt;&gt; prediction for CG55906-04 is cyt (k = 23)                  
 
      A search of the NOV32a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 32D.  
               TABLE 32D                          Geneseq Results for NOV32a                                         NOV32a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value                                             AAO21705   Human secreted protein SEQ ID No   1 . . . 1372   1297/1372   (94%)   0.0           47 -  Homo sapiens , 1325 aa.   1 . . . 1325   1306/1372   (94%)           [WO200238602-A2, 16-MAY-2002]       ABB12254   Human S3-12 homologue, SEQ ID   1 . . . 1235   1234/1235   (99%)   0.0           NO: 2624 -  Homo sapiens , 1250 aa.   17 . . . 1250    1234/1235   (99%)           [WO200157188-A2, 09-AUG-2001]       ABP53597   Human NOV19 protein SEQ ID   1 . . . 1074   1026/1080   (95%)   0.0           NO: 58 -  Homo sapiens , 1225 aa.   1 . . . 1033   1026/1080   (95%)           [WO200262999-A2, 15-AUG-2002]       AAY95851   Autoantigen diagnostic of   314 . . . 749     431/436   (98%)   0.0           endometriosis -  Homo sapiens , 439   4 . . . 439    432/436   (98%)           aa. [WO200047739-A2, 17-AUG-2000]       AAY48492   Human breast tumour-associated   1049 . . . 1372     323/324   (99%)   0.0           protein 37 -  Homo sapiens , 324 aa.   1 . . . 324    323/324   (99%)           [DE19813835-A1, 23-SEP-1999]                  
 
      In a BLAST search of public sequence databases, the NOV32a protein was found to have homology to the proteins shown in the BLASTP data in Table 32E.  
               TABLE 32E                          Public BLASTP Results for NOV32a                                         NOV32a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             Q96Q06   Hypothetical protein KIAA1881 -    91 . . . 1372   1256/1348   (93%)   0.0             Homo sapiens  (Human), 1348 aa    1 . . . 1348   1264/1348   (93%)           (fragment).       O88492   S3-12 -  Mus musculus  (Mouse),    1 . . . 1370   843/1432   (58%)   0.0           1403 aa.    1 . . . 1401   1043/1432   (71%)       Q98MG7   Hypothetical glycine-rich protein   141 . . . 1141   352/1088   (32%)   5e−71           mlr0587 -  Rhizobium loti     1078 . . . 2144    387/1088   (35%)           ( Mesorhizobium loti ), 3145 aa.       Q98MG8   Hypothetical glycine-rich protein   128 . . . 1141   325/1070   (30%)   8e−63           mlr0585 -  Rhizobium loti     329 . . . 1379   384/1070   (35%)           ( Mesorhizobium loti ), 2147 aa.       Q96WU8   Hypothetical 119.8 kDa protein -   140 . . . 1088   265/996   (26%)   4e−42             Schizosaccharomyces pombe     266 . . . 1173   348/996   (34%)           (Fission yeast), 1195 aa (fragment).                  
 
      PFam analysis predicts that the NOV32a protein contains the domains shown in the Table 32F.  
               TABLE 32F                          Domain Analysis of NOV32a                                                     Identities/               Pfam   NOV32a       Similarities for   Expect           Domain   Match Region       the Matched Region   Value                                                     LEA    87 . . . 156   16/75   (21%)   0.00076                   44/75   (59%)           LEA   516 . . . 589   15/76   (20%)   0.96                   46/76   (61%)           perilipin    592 . . . 1356   89/788   (11%)   0.045                   435/788   (55%)                      
 
     Example 33  
      The NOV33 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 33A.  
                                   TABLE 33A                                      NOV33a,CG55908-01   SEQ ID NO:813   840 bp               DNA Sequence   ORF Start: at 2   ORF Stop: TAA at 836                       G GCCTCCGGGATTTGCTACCTTTTTGGCTCCCTGCTCGTCGAACTGCTCTTCTCACGGGCTGTCGCCT           TCAATCTGGACGTGATGGGTGCCTTGCGCAAGGAGGGCGAGCCAGGCAGCCTCTTCGGCTTCTCTGTG       GCCCTGCACCGGCAGTTGCAGCCCCGACCCCAGAGCTGGCTGCTGGTGGGTGCTCCCCAGGCCCTGGC       TCTTCCTGGGCAGCAGGCGAATCGCACTGGAGGCCTCTTCGCTTGCCCGTTGAGCCTGGAGGAGACTG       ACTGCTACAGAGTGGACATCGACCAGGGAGCTGATATGCAAAAGGAAAGCAAGGAGAACCAGTGGTTG       GGAGTCAGTGTTCGGAGCCAGGGGCCTGGGGGCAAGATTGTTGACTGCGCCCGGGGCACGGCCAACTG       TGTGGTGTTCAGCTGCCCACTCTACAGCTTTGACCGCGCGGCTGTGCTGCATGTCTGGGGCCGTCTCT       GGAACAGCACCTTTCTGGAGGAGTACTCAGCTGTGAAGTCCCTGGAAGTGATTGTCCGGGCCAACATC       ACAGTGAAGTCCTCCATAAAGAACTTGATGCTCCGAGATGCCTCCACAGTGATCCCAGTGATGGTATA       CTTGGACCCCATGGCTGTGGTGGCAGAAGGAGTGCCCTGGTGGGTCATCCTCCTGGCTGTACTGGCTG       GGCTGCTGGTGCTAGCACTGCTGGTGCTGCTCCTGTGGAAGTGTGGCTTCTTCCATCGGAGCAGCCAG       AGCTCATCTTTTCCCACCAACTATCACCGGGCCTGTCTGGCTGTGCAGCCTTCAGCCATGGAAGTTGG       GGGTCCAGGGACTGTGGGG TAA   CT                                                   NOV33a, CG55908-01   SEQ ID NO:814   278 aa   MW at 30129.7 kD               Protein Sequence                     ASGTCYLFGSLLVELLFSRAVAFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALA           LPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPGGKIVDCARGTANC       VVFSCPLYSFDPAAVLHVWGRLWNSTFLEEYSAVKSLEVIVRANITVKSSIKNLMLRDASTVIPVMVY       LDPMAVVAEGVPWWVILLAVLAGLLVLALLVLLLWKCGFFHRSSQSSSFPTNYHRACLAVQPSAMEVG       GPGTVG                                             NOV33b, 253116407   SEQ ID NO:815   780 bp               DNA Sequence   ORF Start: at 1   ORE Stop: end of sequence                     GGATCCTTCAATCTGGACGTGATGGGTGCCTTGCGCAAGGAGGGCGAGCCAGGCAGCCTCTTCGGCTT           CTCTGTGGCCCTGCACCGGCAGTTGCAGCCCCGACCCCAGAGCTGGCTGCTGGTGGGTGCTCCCCAGG       CCCTGGCTCTTCCTGGGCAGCAGGCGAATCGCACTGGAGGCCTCTTCGCTTGCCCGTTGAGCCTGGAG       GAGACTGACTGCTACAGAGTGGACATCGACCAGGGAGCTGATATGCAAAAGGAAAGCAAGGAGAACCA       GTGGTTGGGAGTCAGTGTTCGGAGCCAGGGGCCTGGGGGCAAGATTGTTGACTGCGCCCGGGGCACGG       CCAACTGTGTGGTGTTCAGCTGCCCACTCTACAGCTTTGACCGCGCGGCTGTGCTGCATGTCTGGGGC       CGTCTCTGGAACAGCACCTTTCTGGAGGAGTACTCAGCTGTGAAGTCCCTGGAAGTGATTGTCCGGGC       CAACATCACAGTGAAGTCCTCCATAAAGAACTTGATGCTCCGAGATGCCTCCACAGTGATCCCAGTGA       TGGTATACTTGGACCCCATGGCTGTGGTGGCAGAAGGAGTGCCCTGGTGGGTCATCCTCCTGGCTGTA       CTGGCTGGGCTGCTGGTGCTAGCACTGCTGGTGCTGCTCCTGTGGAAGTGTGGCTTCTTCCATCGGAG       CAGCCAGAGCTCATCTTTTCCCACCAACTATCACCGGGCCTGTCTGGCTGTGCAGCCTTCAGCCATGG       AAGTTGGGGGTCCAGGGACTGTGGGGCTCGAG                                                 NOV33b, 253116407   SEQ ID NO:816   260 aa   MW at 28204.4 kD               Protein Sequence                     GSFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLE           ETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPGGKIVDCARGTANCVVFSCPLYSFDRAAVLHVWG       RLWNSTFLEEYSAVKSLEVIVRANITVKSSIKNLMLRDASTVIPVMVYLDPMAVVAEGVPWWVILLAV       LAGLLVLALLVLLLWKCGFFHRSSQSSSFPTNYHRACLAVQPSAMEVGGPGTVGLE                                             NOV33c, 253116412   SEQ ID NO:817   567 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GGATCCTTCAATCTGGACGTGATGGGTGCCTTGCGCAAGGAGGGCGAGCCAGGCAGCCTCTTCGGCTT           CTCTGTGGCCCTGCACCGGCAGTTGCAGCCCCGACCCCAGAGCTGGCTGCTGGTGGGTGCTCCCCAGG       CCCTGGCTCTTCCTGGGCAGCAGGCGAATCGCACTGGAGGCCTCTTCGCTTGCCCGTTGAGCCTGGAG       GAGACTGACTGCTACAGAGTGGACATCGACCAGGGAGCTGATATGCAAAAGGAAAGCAAGGAGAACCA       GTGGTTGGGAGTCAGTGTTCGGAGCCAGGGGCCTGGGGGCAAGATTGTTGACTGCGCCCGGGGCACGG       CCAACTGTGTGGTGTTCAGCTGCCCACTCTACAGCTTTGACCGCGCGGCTGTGCTGCATGTCTGGGGC       CGTCTCTGGAACAGCACCTTTCTGGAGGAGTACTCAGCTGTGAAGTCCCTGGAAGTGATTGTCCGGGC       CAACATCACAGTGAAGTCCTCCATAAAGAACTTGATGCTCCGAGATGCCTCCACAGTGATCCCAGTGA       TGGTATACTTGGACCCCCTCGAG                                                 NOV33c, 253116412   SEQ ID NO:818   189 aa   MW at 20685.5 kD               Protein Sequence                     GSFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLE           ETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPGGKIVDCARGTANCVVFSCPLYSFDRAAVLHVWG       RLWNSTFLEEYSAVKSLEVIVRANTTVKSSIKNLMLRDASTVIPVMVYLDPLE                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 33B.  
               TABLE 33B                       Comparison of the NOV33 protein sequences.                                                NOV33a   ASGICYLFGSLLVELLFSRAVAFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLL   (SEQ ID NO:814)                   NOV33b   --------------------GSFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLL   (SEQ ID NO:816)               NOV33c   --------------------GSFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLL   (SEQ ID NO:818)               NOV33a   VGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQ               NOV33b   VGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQ               NOV33c   VGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQ               NOV33a   GPGGKIVDCARGTANCVVFSCPLYSFDRAAVLHVWGRLWNSTFLEEYSAVKSLEVIVRAN               NOV33b   GPGGKIVDCARGTANCVVFSCPLYSFDRAAVUHVWGRLWNSTFLEEYSAVKSLEVIVRAN               NOV33c   GPGGKIVDCARGTANCVVFSCPLYSFDRAAVLHVWGRLWNSTFLEEYSAVKSLEVIVRAN               NOV33a   ITVKSSIKNLMLRDASTVIPVMVYLDPMAVVAEGVPWWVTLLAVLAGLLVLAILVLLLWK               NOV33b   ITVKSSIKNLMLRDASTVIPVMVYLDPMAVVAEGVPWWVTLLAVLAGLLVLALLVLLLWK               NOV33c   ITVKSSIKNLMLRDASTVIPVMVYLDPLE-------------------------------               NOV33a   CGFFHRSSQSSSFPTNYHRACLAVQPSAMEVGGPGTVG--               NOV33b   CGFFHRSSQSSSFPTNYHRACLAVQPSAMEVGGPGTVGLE               NOV33c   ----------------------------------------                  
 
      Further analysis of the NOV33a protein yielded the following properties shown in Table 33C.  
               TABLE 33C                       Protein Sequence Properties NOV33a                                        SignalP analysis:   Cleavage site between residues 23 and 24       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 0; pos. chg 0; neg. chg 0           H-region:   length 13; peak value 8.16           PSG score:   3.76                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −0.41           possible cleavage site: between 22 and 23                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 22)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 23           Tentative number of TMS(s) for the threshold 0.5: 2           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 219-235               −15.81                             PERIPHERAL   Likelihood = 2.65 (at 136)                         ALOM score: −15.81 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 11           Charge difference: −2.0 C(−1.0)-N( 1.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 1a (cytoplasmic tail 236 to 278)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   1   Hyd Moment(75):   2.41           Hyd Moment(95):   4.01   G content:   2           D/E content:   2   S/T content:   3                         Score: −6.94       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 7.9%           NLS Score: −0.471       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: 256       Dileucine motif in the tail: found                         LL at 236                 checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 94.1       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         44.4%: endoplasmic reticulum           22.2%: Golgi           11.1%: plasma membrane           11.1%: vesicles of secretory system           11.1%: extracellular, including cell wall                 &gt;&gt; prediction for CG55908-01 is end (k = 9)                  
 
      A search of the NOV33a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 33D.  
               TABLE 33D                          Geneseq Results for NOV33a                                         NOV33a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value                                             ABG69620   Human NOV13 protein -  Homo     1 . . . 278   278/278   (100%)    e−161             sapiens , 278 aa. [WO200250277-A2,   1 . . . 278   278/278   (100%)           27-JUN-2002]       ABG61788   Novel ITGA7 precursor-like receptor   58 . . . 278    167/230   (72%)   3e−84           protein #1 -  Homo sapiens , 1143 aa.   917 . . . 1143    180/230   (77%)           [WO200229058-A2, 11-APR-2002]       ABG61789   Novel ITGA7 precursor-like receptor   128 . . . 278    150/151   (99%)   4e−83           protein #2 -  Homo sapiens , 1035 aa.   885 . . . 1035    151/151   (99%)           [WO200229058-A2, 11-APR-2002]       ABU58459   Human PRO polypeptide #60 -  Homo     1 . . . 130   129/130   (99%)   3e−70             sapiens , 1141 aa. [US2003027272-   12 . . . 141    129/130   (99%)           A1, 06-FEB-2003]       ABU56990   Human PRO polypeptide #60 -  Homo     1 . . . 130   129/130   (99%)   3e−70             sapiens , 1141 aa. [US2003027280-   12 . . . 141    129/130   (99%)           A1, 06-FEB-2003]                  
 
      In a BLAST search of public sequence databases, the NOV33a protein was found to have homology to the proteins shown in the BLASTP data in Table 33E.  
               TABLE 33E                          Public BLASTP Results for NOV33a                                         NOV33a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               CAD48689   Sequence 41 from Patent   58 . . . 278   167/230 (72%)   1e−83           WO0229058 -  Homo sapiens     917 . . . 1143   180/230 (77%)           (Human), 1143 aa.       JC5950   integrin alpha-7 chain precursor -    1 . . . 130   129/130 (99%)   9e−70           human, 1137 aa.   12 . . . 141   129/130 (99%)       AAH50280   Integrin, alpha 7 -  Homo sapiens      1 . . . 130   129/130 (99%)   9e−70           (Human), 1137 aa.   12 . . . 141   129/130 (99%)       Q13683   Integrin alpha-7 precursor -  Homo      1 . . . 130   129/130 (99%)   9e−70             sapiens  (Human), 1181 aa.   12 . . . 141   129/130 (99%)       S40148   integrin alpha-7A chain - rat, 148   150 . . . 278    118/129 (91%)   1e−61           aa.    1 . . . 129   122/129 (94%)                  
 
      PFam analysis predicts that the NOV33a protein contains the domains shown in the Table 33F.  
               TABLE 33F                       Domain Analysis of NOV33a                                                        Pfam   NOV33a   Identities/   Expect           Domain   Match Region   Similarities for   Value                   the Matched Region                      
 
     Example 34  
      The NOV34 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 34A.  
               TABLE 34A                       NOV34 Sequence Analysis                                                NOV34a, CG56077-06   SEQ ID NO:819   2106 bp           DNA Sequence   ORF Start: at 1   ORF Stop: TGA at 1636                     TCCCGAGACTTTGGAAGTTCTCAGCTATTACTTTATTACATAGGATTTCTGTGTCTTTTCTCATCTCT           TTTCCTTTTGGAAAGACCCCCAAAGGGAAAGTGTCCCCTGCGCTGCTCCTGCTCTAAAGACAGCGCCC       TGTGTGAGGGCTCCCCGGACCTGCCCGTCAGCTTCTCTCCGACCCTGCTGTCACTGTCACTCGTCAGG       ACGGGAGTCACCCAGCTGAAGGCCGGCAGCTTCCTGAGAATTCCGTCTCTGCACCTGCTGCTCTTCAC       CTCCAACTCCTTCTCCGTGATTGAGGACGATGCATTTGCGGGCCTGTCCCACCTGCAGTACCTGTTCA       TCGAGGACAATGAGATTGGCTCCATCTCTAAGAATGCCCTCAGAGGACTTCGCTCGCTTACACACCTG       AGCCTGGCCAATAACCATCTGGAGACCCTCCCCAGATTCCTGTTCCGAGGCCTGGACACCCTTACTCA       TGTGGACCTCCGCGGGAACCCGTTCCAGTGTGACTGCCGCGTCCTCTGGCTCCTGCAGTGGATGCCCA       CCGTGAATGCCAGCGTGGGGACCGGCGCCTGTGCGGGCCCCGCCTCCCTGAGCCACATGCAGCTCCAC       CACCTCGACCCCAAGACTTTCAAGTGCCCACCCACAGAGCTGTCCTGGTTCCAGACGGTGGGGGAGTC       GGCACTGAGCGTAGAGCCCTTCTCCTACCAAGGGGAGCCTCACATTGTGCTGGCACAGCCCTTCGCCG       GCCGCTGCCTGATTCTCTCCTGGGACTACAGCCTGCAGCGCTTCCGGCCCGAGGAAGAGCTGCCCACA       GCGGCCTCCGTGGTGTCCTGCAAGCCACTGGTGCTGGGCCCGAGCCTCTTCGTGCTGGCTGCCCGCCT       GTGGGGGGGCTCACAGCTGTGGGCCCGGCCCAGTCCCGGCCTGCGCCTGGCCCCAACGCAGACCCTGG       CCCCGCGGCGGCTGCTGCGGCCCAATGACGCCGAGCTCCTGTGGCTGGAAGGGCAACCCTGCTTCGTG       GTGGCCGATGCCTCCAAGGCGGGCAGCACCACGCTGCTGTGCCGCGACGGGCCCGGCTTTTACCCGCA       CCAGAGCCTGCACGCCTGGCACCGGGACACGGACGCTGAGGCCCTGGAGCTGGACGGCCGGCCCCACC       TGCTGCTGGCCTCGGCTTCCCAGCGGCCCGTGCTCTTCCACTGGACCGGTGGCCGCTTCGAGAGACGC       ACGGACATCCCCGAGGCCGAGGATGTCTATGCCACACGCCACTTCCAGGCTGGTGGGGACGTGTTCCT       GTGCCTCACACGCTACATTGGGGACTCCATGGTGATGCGCTGGGACGGCTCCATGTTTCGTCTGCTGC       AGCAACTTCCCTCGCGCGGTGCCCACGTCTTCCAGCCACTGCTCATCGCCAGGGACCAGTTGGCCATC       CTAGGCAGCGACTTCGCCTTCAGCCAGGTCCTCCGCCTTGAGCCTGACAAGGGGCTCCTGGAGCCACT       GCAGGAGCTGGGGCCTCCGGCCCTGGTGGCCCCCCGTGCCTTTGCCCACATCACTATGGCCGGCAGAC       GCTTCCTCTTTGCTGCTTGCTTTAAGGGCCCCACACAGATCTACCAGCATCACGAGATCGACCTCAGT       GCC TGA   GACCACCAACGGGACTCTGGGCATGGCTGGGGCCCCTGGACGGCCCCTTGGCTGGCTCCTGG           CCCTACTTGGGGTGATGGTCCGCCTGTGAGCTGCTGACCGTGGGCCACGTTCATCAGCCACACGTCTA           GGCCTTAAGCCCACTTCTTAAAGGATCTGCACCCATGGGGGGACATAGAGGGTCCCAGCCTACTGGAC           CTCCCGAGCTGCCCTTCAGGTCTAAAGCAACATCTGGACATCTCGGCTGGGGCAGATTCCCCATCAAA           GGCAACCTGGGGGGTGCAGGCTGGTGCACTGCATGGAGTCGAGGTGGAGGTCACGTGCAGAGCTCCAT           GAGGTCCCGGAGCCCCCCTCTCAACCCGCTCCTACCCCGCTGGTCCCTCTGAAAGCACCGAGGGGTTG           ATGGCATTCCTTTCCCATTCTAAACTCCACGCAGCCAATCGCTTTCCTGGAGGAGCGCCAACCTCG                                           NOV34a, CG56077-06   SEQ ID NO:820   545 aa   MW at 60447.7 kD           Protein Sequence                     SRDFGSSQLLLYYIGFLCLFSSLFLLERPPKGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLSLVR           TGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHL       SLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLH       HLDPKTFKCPPTELSWFQTVGESALSVEPFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEELPT       AASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLWLEGQPCFV       VADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGRPHLLLASASQRPVLFHWTGGRFERR       TDIPEAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQPLLIARDQLAI       LGSDFAFSQVLRLEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLFAACFKGPTQIYQ       HHEIDLSA                                     NOV34b, CG56077-01   SEQ ID NO:821   1859 bp           DNA Sequence   ORF Start: ATG at 101   ORF Stop: TGA at 1760                       GTAACTCCTCTTCATCCACTGGGGAGGAAGGTGAGGCAGGCGGGCCCAATTCATTCGCCTCCGGTACT               TGCAAGCCTCGCTCAGTCTTAAGCAAGAGGGG   ATG GATTCGCCCGCAGCACTGAGAATCCAGGGGCAG       GCGGGATGGCGTTCAGGCGCTGTTGCTAGAAATCTCTGTCTTTACTCTGTTTTGGTCATTACGGAGGG       AAGACAGCCCCCAAAGGGAAAGTGTCCCCTGCGCTGCTCCTGCTCTAAAGACAGCGCCCTGTGTGAGG       GCTCCCCGGACCTGCCCGTCAGCTTCTCTCCGACCCTGCTGTCACTCTCACTCGTCAGGACGGGAGTC       ACCCAGCTGAAGGCCGGCAGCTTCCTGAGAATTCCGTCTCTGCACCTGCTCCTCTTCACCTCCAACTC       CTTCTCCGTGATTGAGGACGATGCATTTGCGGGCCTGTCCCACCTGCAGTACCTCTTCATCGAGGACA       ATGAGATTGGCTCCATCTCTAAGAATGCCCTCAGAGGACTTCGCTCGCTTACACACCTAAGCCTGGCC       AATAACCATCTGGAGACCCTCCCCAGATTCCTGTTCCGAGGCCTGGACACCCTTACTCATGTGGACCT       CCGCGGGAACCCGTTCCAGTGTGACTGCCGCGTCCTCTGGCTCCTGCAGTGGATGCCCACCGTGAATG       CCAGCGTGGGGACCGGCGCCTGTGCGGGCCCCGCCTCCCTGAGCCACATGCAGCTCCACCACCTCGAC       CCCAAGACTTTCAAGTGCAGAGCCATAGAGCTGTCCTGGTTCCAGACGGTGGGGGAGTCGGCACTGAG       CGTAGAGCCCTTCTCCTACCAAGGGGAGCCTCACATTGTGCTGGCACAGCCCTTCGCCGGCCGCTGCC       TGATTCTCTCCTGGGACTACAGCCTGCAGCGCTTCCGGCCCGAGGAAGAGCTGCCCGCGGCCTCCGTG       GTGTCCTGCAAGCCACTGGTGCTGGGCCCGAGCCTCTTCGTGCTGGCTGCCCGCCTGTGGGGGGGCTC       ACAGCTGTGGGCCCGGCCCAGTCCCGGCCTGCGCCTGGCCCCAACGCAGACCCTGGCCCCGCGGCGGC       TGCTGCGGCCCAATGACGCCGAGCTCCTGTGGCTGGAAGGGCAACCCTGCTTCGTGGTGGCCGATGCC       TCCAAGGCGGGCAGCACCACGCTGCTGTGCCGCGACGGGCCCGGCTTTTACCCGCACCAGAGCCTGCA       CGCCTGGCACCGGGACACGGACGCTGAGGCCCTGGAGCTGGACGGCCGGCCCCACCTGCTGCTGGCCT       CGGCTTCCCAGCGGCCCGTGCTCTTCCACTGGACCGGTGGCCGCTTCGAGAGACGCACAGACATCCCG       AGGGCCGAGGATGTCTATGCCACACGCCACTTCCAGGCTGGTGGGGACGTGTTCCTGTGCCTCACACG       CTACATTGGGGACTCCATGGTCATGCGCTGGGACGGCTCCATGTTTCGTCTGCTGCAGCAACTTCCCT       CGCGCGGTGCCCACGTCTTCCAGCCACTGCTCATCGCCAGGGACCAGCTGGCCATCCTAGGCAGCGAC       TTCGCCTTCAGCCAGGTCCTCCGCCTTGAGCCTGACAAGGGGCTCCTGGAGCCACTGCAGGAGCTGGG       GCCTCCGGCCCTGGTGGCCCCCCGTGCCTTTGCCCACATCACTATGGCCGGCAGACGCTTCCTCTTTG       CTGCTTGCTTTAAGGGCCCCACACAGATCTACCAGCATCACGAGATCGACCTCAGTGCC TGA   GACCAC           CAACGGGACTCTGGGCATGGCTGGGGCCCCTGGACGGCCCCTTGGCTGGCTCCTGGCCCTACTTGGGG           TGATGGCCCGCCTGTGAGCTGCT                                           NOV34b, CG56077-01   SEQ ID NO:822   553 aa   MW at 61118.5 kD           Protein Sequence                     MDSPAALRIQGQAGWRSGAVARNLCLYSVLVITEGRQPPKGKCPLRCSCSKDSALCEGSPDLPVSFSP           TLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNAL       RGLRSLTHLSLANNHLETLPRFLFRGLDTLTNVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGP       ASLSHMQLHHLDPKTFKCRATELSWFQTVGESALSVEPFSYQGEPHIVLAQPFAGRCLILSWDYSLQR       FRPEEELPAASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLW       LEGQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGRPHLLLASASQRPVLFHW       TGGRFERRTDIPRAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQPLL       IARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLFAACFKGPTQIY       QHHEIDLSA                                     NOV34c, CG56077-02   SEQ ID NO:823   1482 bp           DNA Sequence   ORF Start: at 1   ORF Stop: TGA at 1480                     TCCCGAGACTTTGGAAGTTCTCAGCTATTACTTTATTACATAGGATTTCTGTGTCTTTTCTCATCTCT           TTTCCTTTTGGAAATTGGAAGACCCCCAAAGGGAAAGTGTCCCCTGCGCTGCTCCTGCTCTAAAGACA       GCGCCCTGTGTGAGGGCTCCCCGGACCTGCCCGTCAGCTTCTCTCCGACCCTGCTGTCACTGACTGCC       CACATCCCCAGCTCACTCGTCAGGACGGGAGTCACCCAGCTGAAGGCCGGCAGCTTCCTGAGAATTCC       GTCTCTGCACCTGCTGCTCTTCACCTCCAACTCCTTCTCCGTGATTGAGGACGATGCATTTGCGGGCC       TGTCCCACCTGCAGTACCTGTTCATCGAGGACAATGAGATTGGCTCCATCTCTAAGAATGCCCTCAGA       GGACTTCGCTCGCTTACACACCTGAGCCTGGCCAATAACCATCTGGAGACCCTCCCCAGATTCCTGTT       CCGAGGCCTGGACACCCTTACTCATGTGGACCTCCGCGGGAACCCGTTCCAGTGTGACTGCCGCGTCC       TCTGGCTCCTGCAGTGGATGCCCACCGTGAATGCCAGCGTGGGGACCGGCGCCTGTGCGGGCCCCGCC       TCCCTGAGCCACATGCAGCTCCACCACCTCGACCCCAAGACTTTCAAGTGCACAGCGGCCTCCGTGGT       GTCCTGCAAGCCACTGGTGCTGGGCCCGAGCCTCTTCGTGCTGGCTGCCCGCCTGTGGGGGGGCTCAC       AGCTGTGGGCCCGGCCCAGTCCCGGCCTGCGCCTGGCCCCAACGCAGACCCTGGCCCCGCGGCGGCTG       CTGCGGCCCAATGACGCCGAGCTCCTGTGGCTGGAAGGGCAACCCTGCTTCGTGGTGGCCGATGCCTC       CAAGGCGGGCAGCACCACGTGCAGCGCTTCCGGCCCGAGGAAGAGCTGCCCGAGCCTGCACGCCTGGC       ACCGGGACACGGACGCTGAGGCCCTGGAGCTGGACGGCCGGCCCCACCTGCTGCTGGCCTCGGCTTCC       CAGCGGCCCGTGCTCTTCCACTGGACCGGTGGCCGCTTCGAGAGACGCACGGACATCCCCGAGGCCGA       GGATGTCTATGCCACACGCCACTTCCAGGCTGGTGGGGACGTGTTCCTGTGCCTCACACGCTACATTG       GGGACTCCATGGTCATGCGCTGGGACGGCTCCATGTTTCGTCTGCTGCAGCAACTTCCCTCGCGCGGT       GCCCACGTCTTCCAGCCACTGCTCATCGCCAGGGACCAATTGGCCATCCTAGGCAGCGACTTCGCCTT       CAGCCAGGTCCTCCGCCTTGAGCCTGACAAGGGGCTCCTGGAGCCACTGCAGGAGCTGGGGCCTCTGG       CCCTGGTGGCCCCCCGTGCCTTTGCCCACATCACTATGGCCGGCAGACGCTTCCTCTTTGCTGCTTGC       TTTAAGGGCCCCACACAGATCTACCAGCATCACGAGATCGACCTCAGTGCC TGA                                           NOV34c, CG56077-02   SEQ ID NO:824   493 aa   MW at 54197.8 kD           Protein Sequence                     SRDFGSSQLLLYYIGFLCLFSSLFLLEIGRPPKGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLTA           HIPSSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALR       GLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPA       SLSHMQLHHLDPKTFKCTAASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRL       LRPNDAELLWLEGQPCFVVADASKAGSTTCSASGPRKSCPSLHAWHRDTDAEALELDGRPHLLLASAS       QRPVLFHWTGGRFERRTDIPEAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRG       AHVFQPLLIARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGPLALVAPRAFAHITMAGRRFLFAAC       FKGPTQIYQHHEIDLSA                                     NOV34d, CG56077-03   SEQ ID NO:825   741 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     ACGGAGGGAAGACAGCCCCCAAAGGGAAAGTGTCCCCTGCGCTGCTCCTGCTCTAAAGACAGCGCCCT           GTGTGAGGGCTCCCCGGACCTGCCCGTCAGCTTCTCTCCGACCCTGCTGTCACTCTCACTCGTCAGGA       CGGGAGTCACCCAGCTGAAGGCCGGCAGCTTCCTGAGAATTCCGTCTCTGCACCTGCTCCTCTTCACC       TCCAACTCCTTCTCCGTGATTGAGGACGATGCATTTGCGGGCCTGTCCCACCTGCAGTACCTCTTCAT       CGAGGACAATGAGATTGGCTCCATCTCTAAGAATGCCCTCAGAGGACTTCGCTCGCTTACACACCTAA       GCCTGGCCAATAACCATCTGGAGACCCTCCCCAGATTCCTGTTCCGAGGCCTGGACACCCTTACTCAC       GTGGACCTCCGCGGGAACCCGTTCCAGTGTGACTGCCGCGTCCTCTGGCTCCTGCAGTGGATGCCCAC       CGTGAATGCCAGCGTGGGGACCGGCGCCTGTGCGGGCCCCGCCTCCCTGAGCCACATGCAGCTCCACC       ACCTCGACCCCAAGACTTTCAAGTGCAGAGCCATAGAGCTGTCCTGGTTCCAGACGGTGGGGGAGTCG       GCACTGAGCGTAGAGCCCTTCTCCTACCAAGGGGAGCCTCACATTGTGCTGGCACAGCCCTTCGCCGG       CCGCTGCCTGATTCTCTCCTGGGACTACAGCCTGCAGCGCTTCCGGCCCGAGGAAGAGCTG                                         NOV34d, CG56077-03   SEQ ID NO:826   247 aa   MW at 27380.0 kD           Protein Sequence                     TEGRQPPKGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFT           SNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTH       VDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGES       ALSVEPFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEEL                                     NOV34e, CG56077-04   SEQ ID NO:827   741 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     ACGGAGGGAAGACAGCCCCCAAAGGGAAAGTGTCCCCTGCGCTGCTCCTGCTCTAAAGACAGCGCCCT           CGGGAGTCACCCAGCTGAAGGCCGGCAGCTTCCTGAGAATTCCGTCTCTGCACCTGCTCCTCTTCACC       TCCAACTCCTTCTCCGTGATTGAGGACGATGCATTTGCGGGCCTGTCCCACCTGCAGTACCTCTTCAT       CGAGGACAATGAGATTGGCTCCATCTCTAAGAATGCCCTCAGAGGACTTCGCTCGCTTACACACCTAA       GCCTGGCCAATAACCATCTGGAGACCCTCCCCAGATTCCTGTTCCGAGGCCTGGACACCCTTACTCAC       GTGGACCTCCGCGGGAACCCGTTCCAGTGTGACTGCCGCGTCCTCTGGCTCCTGCAGTGGATGCCCAC       CGTGAATGCCAGCGTGGGGACCGGCGCCTGTGCGGGCCCCGCCTCCCTGAGCCACATGCAGCTCCACC       ACCTCGACCCCAAGACTTTCAAGTGCAGAGCCATAGAGCTGTCCTGGTTCCAGACGGTGGGGGAGTCG       GCACTGAGCGTAGAGCCCTTCTCCTACCAAGGGGAGCCTCACATTGTGCTGGCACAGCCCTTCGCCGG       CCGCTGCCTGATTCTCTCCTGGGACTACAGCCTGCAGCGCTTCCGGCCCGAGGAAGAGCTG                                         NOV34e, CG56077-04   SEQ ID NO:828   247 aa   MW at 27380.0 kD           Protein Sequence                     TEGRQPPKGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFT           SNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTH       VDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGES       ALSVEPFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEEL                                     NOV34f, CG56077-05   SEQ ID NO:829   741 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     ACGGAGGGAAGACAGCCCCCAAAGGGAAAGTGTCCCCTGCGCTGCTCCTGCTCTAAAGACAGCGCCCT           GTGTGAGGGCTCCCCGGACCTGCCCGTCAGCTTCTCTCCGACCCTGCTGTCACTCTCACTCGTCAGGA       CGGGAGTCACCCAGCTGAAGGCCGGCAGCTTCCTGAGAATTCCGTCTCTGCACCTGCTCCTCTTCACC       TCCAACTCCTTCTCCGTGATTGAGGACGATGCATTTGCGGGCCTGTCCCACCTGCAGTACCTCTTCAT       CGAGGACAATGAGATTGGCTCCATCTCTAAGAATGCCCTCAGAGGACTTCGCTCGCTTACACACCTAA       GCCTGGCCAATAACCATCTGGAGACCCTCCCCAGATTCCTGTTCCGAGGCCTGGACACCCTTACTCAC       GTGGACCTCCGCGGGAACCCGTTCCAGTGTGACTGCCGCGTCCTCTGGCTCCTGCAGTGGATGCCCAC       CGTGAATGCCAGCGTGGGGACCGGCGCCTGTGCGGGCCCCGCCTCCCTGAGCCACATGCAGCTCCACC       ACCTCGACCCCAAGACTTTCAAGTGCAGAGCCATAGAGCTGTCCTGGTTCCAGACGGTGGGGGAGTCG       GCACTGAGCGTAGAGCCCTTCTCCTACCAAGGGGAGCCTCACATTGTGCTGGCACAGCCCTTCGCCGG       CCGCTGCCTGATTCTCTCCTGGGACTACAGCCTGCAGCGCTTCCGGCCCGAGGAAGAGCTG                                         NOV34f, CG56077-05   SEQ ID NO:830   247 aa   MW at 27380.0 kD           Protein Sequence                     TEGRQPPKGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFT           SNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTH       VDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGES       ALSVEPFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEEL                             NOV34g, SNP13374715 of   SEQ ID NO:831   2106 bp           CG56077-06, DNA Sequence   ORF Start: at 1   ORF Stop: TGA at 1636           SNP Pos: 1263   SNP Change: C to T                     TCCCGAGACTTTGGAAGTTCTCAGCTATTACTTTATTACATAGGATTTCTGTGTCTTTTCTCATCTCT           TTTCCTTTTGGAAAGACCCCCAAAGGGAAAGTGTCCCCTGCGCTGCTCCTGCTCTAAAGACAGCGCCC       TGTGTGAGGGCTCCCCGGACCTGCCCGTCAGCTTCTCTCCGACCCTGCTGTCACTGTCACTCGTCAGG       ACGGGAGTCACCCAGCTGAAGGCCGGCAGCTTCCTGAGAATTCCGTCTCTGCACCTGCTGCTCTTCAC       CTCCAACTCCTTCTCCGTGATTGAGGACGATGCATTTGCGGGCCTGTCCCACCTGCAGTACCTGTTCA       TCGAGGACAATGAGATTGGCTCCATCTCTAAGAATGCCCTCAGAGGACTTCGCTCGCTTACACACCTG       AGCCTGGCCAATAACCATCTGGAGACCCTCCCCAGATTCCTGTTCCGAGGCCTGGACACCCTTACTCA       TGTGGACCTCCGCGGGAACCCGTTCCAGTGTGACTGCCGCGTCCTCTGGCTCCTGCAGTGGATGCCCA       CCGTGAATGCCAGCGTGGGGACCGGCGCCTGTGCGGGCCCCGCCTCCCTGAGCCACATGCAGCTCCAC       CACCTCGACCCCAAGACTTTCAAGTGCCCACCCACAGAGCTGTCCTGGTTCCAGACGGTGGGGGAGTC       GGCACTGAGCGTAGAGCCCTTCTCCTACCAAGGGGAGCCTCACATTGTGCTGGCACAGCCCTTCGCCG       GCCGCTGCCTGATTCTCTCCTGGGACTACAGCCTGCAGCGCTTCCGGCCCGAGGAAGAGCTGCCCACA       GCGGCCTCCGTGGTGTCCTGCAAGCCACTGGTGCTGGGCCCGAGCCTCTTCGTGCTGGCTGCCCGCCT       GTGGGGGGGCTCACAGCTGTGGGCCCGGCCCAGTCCCGGCCTGCGCCTGGCCCCAACGCAGACCCTGG       CCCCGCGGCGGCTGCTGCGGCCCAATGACGCCGAGCTCCTGTGGCTGGAAGGGCAACCCTGCTTCGTG       GTGGCCGATGCCTCCAAGGCGGGCAGCACCACGCTGCTGTGCCGCGACGGGCCCGGCTTTTACCCGCA       CCAGAGCCTGCACGCCTGGCACCGGGACACGGACGCTGAGGCCCTGGAGCTGGACGGCCGGCCCCACC       TGCTGCTGGCCTCGGCTTCCCAGCGGCCCGTGCTCTTCCACTGGACCGGTGGCCGCTTCGAGAGACGC       ACGGACATCCCCGAGGCCGAGGATGTCTATGCCACACG   T   CACTTCCAGGCTGGTGGGGACGTGTTCCT       GTGCCTCACACGCTACATTGGGGACTCCATGGTGATGCGCTGGGACGGCTCCATGTTTCGTCTGCTGC       AGCAACTTCCCTCGCGCGGTGCCCACGTCTTCCAGCCACTGCTCATCGCCAGGGACCAGTTGGCCATC       CTAGGCAGCGACTTCGCCTTCAGCCAGGTCCTCCGCCTTGAGCCTGACAAGGGGCTCCTGGAGCCACT       GCAGGAGCTGGGGCCTCCGGCCCTGGTGGCCCCCCGTGCCTTTGCCCACATCACTATGGCCGGCAGAC       GCTTCCTCTTTGCTGCTTGCTTTAAGGGCCCCACACAGATCTACCAGCATCACGAGATCGACCTCAGT       GCC TGA   GACCACCAACGGGACTCTGGGCATGGCTGGGGCCCCTGGACGGCCCCTTGGCTGGCTCCTGG           CCCTACTTGGGGTGATGGTCCGCCTGTGAGCTGCTGACCGTGGGCCACGTTCATCAGCCACACGTCTA           GGCCTTAAGCCCACTTCTTAAAGGATCTGCACCCATGGGGGGACATAGAGGGTCCCAGCCTACTGGAC           CTCCCGAGCTGCCCTTCAGGTCTAAAGCAACATCTGGACATCTCGGCTGGGGCAGATTCCCCATCAAA           GGCAACCTGGGGGGTGCAGGCTGGTGCACTGCATGGAGTCGAGGTGGAGGTCACGTGCAGAGCTCCAT           GAGGTCCCGGAGCCCCCCTCTCAACCCGCTCCTACCCCGCTGGTCCCTCTGAAAGCACCGAGGGGTTG           ATGGCATTCCTTTCCCATTCTAAACTCCACGCAGCCAATCGCTTTCCTGGAGGAGCGCCAACCTCG                                           NOV34g, SNP13374715 of   SEQ ID NO:832   545 aa   MW at 60447.7 kD           CG56077-06, Protein Sequence   SNP Pos: 421       SNP Change: Arg to Arg                     SRDFGSSQLLLYYIGFLCLFSSLFLLERPPKGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLSLVR           TGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHL       SLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLH       HLDPKTFKCPPTELSWFQTVGESALSVEPFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEELPT       AASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLWLEGQPCFV       VADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGRPHLLLASASQRPVLFHWTGGRFERR       TDIPEAEDVYAT   R   HFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGABVFQPLLIARDQLAI       LGSDFAFSQVLRLEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLFAACFKGPTQIYQ       HHEIDLSA                                     NOV34h, SNP13374714 of   SEQ ID NO:833   2106 bp           CG56077-06, DNA Sequence   ORF Start: at 1   ORF Stop: TGA at 1636           SNP Pos: 1402   SNP Change: C to T                     TCCCGAGACTTTGGAAGTTCTCAGCTATTACTTTATTACATAGGATTTCTGTGTCTTTTCTCATCTCT           TTTCCTTTTGGAAAGACCCCCAAAGGGAAAGTGTCCCCTGCGCTGCTCCTGCTCTAAAGACAGCGCCC       TGTGTGAGGGCTCCCCGGACCTGCCCGTCAGCTTCTCTCCGACCCTGCTGTCACTGTCACTCGTCAGG       ACGGGAGTCACCCAGCTGAAGGCCGGCAGCTTCCTGAGAATTCCGTCTCTGCACCTGCTGCTCTTCAC       CTCCAACTCCTTCTCCGTGATTGAGGACGATGCATTTGCGGGCCTGTCCCACCTGCAGTACCTGTTCA       TCGAGGACAATGAGATTGGCTCCATCTCTAAGAATGCCCTCAGAGGACTTCGCTCGCTTACACACCTG       AGCCTGGCCAATAACCATCTGGAGACCCTCCCCAGATTCCTGTTCCGAGGCCTGGACACCCTTACTCA       TGTGGACCTCCGCGGGAACCCGTTCCAGTGTGACTGCCGCGTCCTCTGGCTCCTGCAGTGGATGCCCA       CCGTGAATGCCAGCGTGGGGACCGGCGCCTGTGCGGGCCCCGCCTCCCTGAGCCACATGCAGCTCCAC       CACCTCGACCCCAAGACTTTCAAGTGCCCACCCACAGAGCTGTCCTGGTTCCAGACGGTGGGGGAGTC       GGCACTGAGCGTAGAGCCCTTCTCCTACCAAGGGGAGCCTCACATTGTGCTGGCACAGCCCTTCGCCG       GCCGCTGCCTGATTCTCTCCTGGGACTACAGCCTGCAGCGCTTCCGGCCCGAGGAAGAGCTGCCCACA       GCGGCCTCCGTGGTGTCCTGCAAGCCACTGGTGCTGGGCCCGAGCCTCTTCGTGCTGGCTGCCCGCCT       GTGGGGGGGCTCACAGCTGTGGGCCCGGCCCAGTCCCGGCCTGCGCCTGGCCCCAACGCAGACCCTGG       CCCCGCGGCGGCTGCTGCGGCCCAATGACGCCGAGCTCCTGTGGCTGGAAGGGCAACCCTGCTTCGTG       GTGGCCGATGCCTCCAAGGCGGGCAGCACCACGCTGCTGTGCCGCGACGGGCCCGGCTTTTACCCGCA       CCAGAGCCTGCACGCCTGGCACCGGGACACGGACGCTGAGGCCCTGGAGCTGGACGGCCGGCCCCACC       TGCTGCTGGCCTCGGCTTCCCAGCGGCCCGTGCTCTTCCACTGGACCGGTGGCCGCTTCGAGAGACGC       ACGGACATCCCCGAGGCCGAGGATGTCTATGCCACACGCCACTTCCAGGCTGGTGGGGACGTGTTCCT       GTGCCTCACACGCTACATTGGGGACTCCATGGTGATGCGCTGGGACGGCTCCATGTTTCGTCTGCTGC       AGCAACTTCCCTCGCGCGGTGCCCACGTCTTCCAGCCACTG   T   TCATCGCCAGGGACCAGTTGGCCATC       CTAGGCAGCGACTTCGCCTTCAGCCAGTCCTCCGCCTTGAGCCTGACAAGGGGCTCCTGGAGGCCACT       GCAGGAGCTGGGGCCTCCGGCCCTGGTGGCCCCCCGTGCCTTTGCCCACATCACTATGGCCGGCAGAC       GCTTCCTCTTTGCTGCTTGCTTTAAGGGCCCCACACAGATCTACCAGCATCACGAGATCGACCTCAGT       GCC TGA   GACCACCACCGGGACTCTGGGCATGGCTGGGGCCCCTGGACGGCCCCTTGGCTGGCTCCTGG           CCCTACTTGGGGTGATGGTCCGCCTGTGAGCTGCTGACCGTGGGCCACGTTCATCAGCCACACGTCTA           GGCCTTAAGCCCACTTCTTAAAGGATCTGCACCCATGGGGGGACATAGAGGGTCCCAGCCTACTGGAC           CTCCCGAGCTGCCCTTCAGGTCTAAAGCAACATCTGGACATCTCGGCTGGGGCAGATTCCCCATCAAA           GGCAACCTGGGGGGTGCAGGCTGGTGCACTGCATGGAGTCGAGGTGGAGGTCACGTGCAGAGCTCCAT           GAGGTCCCGGAGCCCCCCTCTCAACCCGCTCCTACCCCGCTGGTCCCTCTGAAAGCACCGAGGGGTTG           ATGGCATTCCTTTCCCATTCTAAACTCCACGCAGCCAATCGCTTTCCTGGAGGAGCGCCAACCTCG                                           NOV34h, SNP13374714 of   SEQ ID NO:834   545 aa   MW at 60481.7 kD           CG56077-06, Protein Sequence   SNP Pos: 468       SNP Change: Leu to Phe                     SRDFGSSQLLLYYIGFLCLFSSLFLLERPPKGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLSLVR           TGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHL       SLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLH       HLDPKTFKCPPTELSWFQTVGESALSVEPFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEELPT       AASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLWLEGQPCFV       VADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGRPHLLLASASQRPVLFHWTGGRFERR       TDIPEAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQPL   F   IARDQLAI       LGSDFAFSQVLRLEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLFAACFKGPTQIYQ       HHEIDLSA                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 34B.  
               TABLE 34B                       Comparison of the NOV34 protein sequences.                                                NOV34a   ------------------------------SRDFGSSQLLLYYIGFLCLFSSLFLLERPP   (SEQ ID NO:820)                   NOV34b   MDSPAALRIQGQAGWRSGAVARNLCLYSVLVITEG---------------------RQPP   (SEQ ID NO:822)               NOV34c   ----------------------------SRDFGSSQLLLYYIGFLCLFSSLFLLEIGRPP   (SEQ ID NO:824)               NOV34d   --------------------------------TEG---------------------RQPP   (SEQ ID NO:826)               NOV34e   --------------------------------TEG---------------------RQPP   (SEQ ID NO:828)               NOV34f   --------------------------------TEG---------------------RQPP   (SEQ ID NO:830)               NOV34a   KGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSL------SLVRTGVTQLKAGSFLRIPS               NOV34b   KGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSL------SLVRTGVTQLKAGSFLRIPS               NOV34c   KGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLTAHIPSSLVRTGVTQLKAGSFLRIPS               NOV34d   KGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSL------SLVRTGVTQLKAGSFLRIPS               NOV34e   KGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSL------SLVRTGVTQLKAGSFLRIPS               NOV34f   KGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSL------SLVRTGVTQLKAGSFLRIPS               NOV34a   LHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLE               NOV34b   LHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLE               NOV34c   LHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLE               NOV34d   LHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLE               NOV34e   LHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLE               NOV34f   LHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLE               NOV34a   TLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLH               NOV34b   TLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLH               NOV34c   TLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLH               NOV34d   TLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLH               NOV34e   TLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLH               NOV34f   TLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLH               NOV34a   HLDPKTFKCPP-----------------------------------TELSWFQTVGESAL               NOV34b   HLDPKTFKCRA-----------------------------------IELSWFQTVGESAL               NOV34c   HLDPKTFKCTAASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRL               NOV34d   HLDPKTFKCRA-----------------------------------IELSWFQTVGESAL               NOV34e   HLDPKTFKCRA-----------------------------------IELSWFQTVGESAL               NOV34f   HLDPKTFKCRA-----------------------------------IELSWFQTVGESAL               NOV34a   S-------------------------------------------------VEPFSYQGEP               NOV34b   S-------------------------------------------------VEPFSYQGEP               NOV34c   LRPNDAELLWLEGQPCFVVADASKAGSTTCSASGPRKSCPSLHAWHRDTDAEALELDGRP               NOV34d   S-------------------------------------------------VEPFSYQGEP               NOV34e   S-------------------------------------------------VEPFSYQGEP               NOV34f   S-------------------------------------------------VEPFSYQGEP               NOV34a   HIVLAQP--------------------------------------------FAGRCLILS               NOV34b   HIVLAQP--------------------------------------------FAGRCLILS               NOV34c   HLLLASASQRPVLFHWTGGRFERRTDIPEAEDVYATRHFQAGGDVFLCLTRYIGDSMVMR               NOV34d   HIVLAQP--------------------------------------------FAGRCLILS               NOV34e   HIVLAQP--------------------------------------------FAGRCLILS               NOV34f   HIVLAQP--------------------------------------------FAGRCLILS               NOV34a   WDYSLQRFR--------------------------------------------PEEELPT               NOV34b   WDYSLQRFR--------------------------------------------PEEELPA               NOV34c   WDGSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGP               NOV34d   WDYSLQRFR--------------------------------------------PEEEL--               NOV34e   WDYSLQRFR--------------------------------------------PEEEL--               NOV34f   WDYSLQRFR--------------------------------------------PEEEL--               NOV34a   AASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLW               NOV34b   ASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLWL               NOV34c   LALVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEIDLSA-------------------               NOV34d   ------------------------------------------------------------               NOV34e   ------------------------------------------------------------               NOV34f   ------------------------------------------------------------               NOV34a   LEGQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGRPHLLLASAS               NOV34b   EGQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGRPHLLLASASQ               NOV34c   ------------------------------------------------------------               NOV34d   ------------------------------------------------------------               NOV34e   ------------------------------------------------------------               NOV34f   ------------------------------------------------------------               NOV34a   QRPVLFHWTGGRFERRTDIPEAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWDGSMFRL               NOV34b   RPVLFHWTGGRFERRTDIPRAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLL               NOV34c   ------------------------------------------------------------               NOV34d   ------------------------------------------------------------               NOV34e   ------------------------------------------------------------               NOV34f   ------------------------------------------------------------               NOV34a   LQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGPPALVAPRA               NOV34b   QQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGPPALVAPRAF               NOV34c   ------------------------------------------------------------               NOV34d   ------------------------------------------------------------               NOV34e   ------------------------------------------------------------               NOV34f   ------------------------------------------------------------               NOV34a   FAHITMAGRPFLFAACFKGPTQIYQHHEIDLSA               NOV34b   AHITMAGRRFLFAACFKGPTQIYQHHEIDLSA-               NOV34c   ---------------------------------               NOV34d   ---------------------------------               NOV34e   ---------------------------------               NOV34f   ---------------------------------                  
 
      Further analysis of the NOV34a protein yielded the following properties shown in Table 34C.  
               TABLE 34C                       Protein Sequence Properties NOV34a                                        SignalP analysis:   Cleavage site between residues 26 and 27       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 3; pos. chg 1; neg. chg 1           H-region:   length 23; peak value 10.35           PSG score:   5.95                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −5.07           possible cleavage site: between 25 and 26                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 2           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 9-25               −5.57                             PERIPHERAL   Likelihood = 2.70 (at 82)                         ALOM score: −5.57 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 16           Charge difference: 2.0 C(3.0)-N(1.0)           C &gt; N: C-terminal side will be inside                 &gt;&gt;&gt;Caution: Inconsistent mtop result with signal peptide       &gt;&gt;&gt; membrane topology: type 1b (cytoplasmic tail 9 to 545)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   1   Hyd Moment(75):   11.37           Hyd Moment(95):   7.33   G content:    2           D/E content:   2   S/T content:    5                         Score: −4.71       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 47 LRC|SC                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 8.8%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: RDFG                 none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: found                         LL at 9           LL at 10           LL at 25           LL at 61           LL at 87           LL at 88           LL at 176           LL at 322           LL at 330           LL at 352           LL at 386           LL at 387                 checking 63 PROSITE DNA binding motifs:                         Leucine zipper pattern (PS00029): *** found ***            LSLANNHLETLPRFLFRGLDTL at 136                 none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         34.8%: nuclear           21.7%: mitochondrial           21.7%: cytoplasmic            8.7%: vesicles of secretory system            4.3%: vacuolar            4.3%: endoplasmic reticulum            4.3%: peroxisomal                 &gt;&gt; prediction for CG56077-06 is nuc (k = 23)                  
 
      A search of the NOV34a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 34D.  
               TABLE 34D                          Geneseq Results for NOV34a                                         NOV34a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               ABB09515   Leu-rich glioma-inactivated protein-like   17 . . . 545    518/531 (97%)   0.0           NOV7a protein, SEQ ID NO: 28 -  Homo     24 . . . 553    521/531 (97%)             sapiens , 553 aa. [WO200253742-A2,           11-JUL-2002]       ABB98246   Human CGDD SEQ ID NO 4 -  Homo     5 . . . 545   519/541 (95%)   0.0             sapiens , 537 aa. [WO200248368-A2,   3 . . . 537   523/541 (95%)           20-JUN-2002]       AAE25347   Human LP polypeptide, LP188 -  Homo     5 . . . 545   519/541 (95%)   0.0             sapiens , 537 aa. [WO200248361-A2,   3 . . . 537   523/541 (95%)           20-JUN-2002]       ABG91403   Primate LP286 - Mammalia, 513 aa.   5 . . . 545   495/541 (91%)   0.0           [WO200263009-A2, 15-AUG-2002]   3 . . . 513   499/541 (91%)       ABU11596   Human MDDT polypeptide SEQ ID 543 -   55 . . . 545    482/493 (97%)   0.0             Homo sapiens , 567 aa.   76 . . . 567    483/493 (97%)           [WO200279449-A2, 10-OCT-2002]                  
 
      In a BLAST search of public sequence databases, the NOV34a protein was found to have homology to the proteins shown in the BLASTP data in Table 34E.  
               TABLE 34E                          Public BLASTP Results for NOV34a                                         NOV34a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q8N135   LGI4 (Leucine-rich glioma inactivated   5 . . . 545   519/541 (95%)   0.0           protein 4) (LGI1-like protein 3) -  Homo          3 . . . 537    523/541 (95%)             sapiens  (Human), 537 aa.       Q8K1S1   LGI1-like protein 3 -  Mus musculus     16 . . . 545    460/530 (86%)   0.0           (Mouse), 537 aa.   9 . . . 537   491/530 (91%)       Q8K4Y8   Leucine-rich glioma inactivated   16 . . . 545    458/530 (86%)   0.0           protein 4 -  Mus musculus  (Mouse),   9 . . . 537   489/530 (91%)           537 aa.       Q9JIA1   Leucine-rich glioma-inactivated 1   1 . . . 545   275/556 (49%)   e−152           protein -  Mus musculus  (Mouse), 557 aa.   6 . . . 557   375/556 (66%)       Q8K4Y5   Leucine-rich glioma inactivated   16 . . . 545    270/540 (50%)   e−151           protein 1 -  Rattus norvegicus  (Rat),   22 . . . 557    367/540 (67%)           557 aa.                  
 
      PFam analysis predicts that the NOV34a protein contains the domains shown in the Table 34F.  
               TABLE 34F                          Domain Analysis of NOV34a                                                     Identities/                           Similarities for           Pfam   NOV34a       the Matched   Expect           Domain   Match Region       Region   Value                                                     LRR   108 . . . 131   7/25   (28%)   0.099                   21/25   (84%)           LRR   132 . . . 155   10/25   (40%)   0.058                   20/25   (80%)           LRRCT   165 . . . 214   21/54   (39%)     1.1e−10                   36/54   (67%)           EPTP   222 . . . 354   30/147   (20%)     1.7e−07                   73/147   (50%)           EPTP   405 . . . 537   58/144   (40%)        8e−39                   90/144   (62%)                      
 
     Example 35  
      The NOV35 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 35A.  
               TABLE 35A                       NOV35 Sequence Analysis                                                NOV35a, CG56110-03   SEQ ID NO:835   874 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAA at 871                       ATG AGGATATTTGCTGTCTTTATATTCATGACCTACTGGCATTTGCTGAACGCATTTACTGTCACGGT           TCCCAAGGACCTATATGTGGTAGAGTATGGTAGCAATATGACAATTGAATGCAAATTCCCAGTAGAAA       AACAATTAGACCTGGCTGCACTAATTGTCTATTGGGAAATGGAGGATAAGAACATTATTCAATTTGTG       CATGGAGAGGAAGACCTGAAGGTTCAGCATAGTAGCTACAGACAGAGGGCCCGGCTGTTGAAGGACCA       GCTCTCCCTGGGAAATGCTGCACTTCAGATCACAGATGTGAAATTGCAGGATGCAGGGGTGTACCGCT       GCATGATCAGCTATGGTGGTGCCGACTACAAGCGAATTACTGTGAAAGTCAATGCCCCATACAACAAA       ATCAACCAAAGAATTTTGGTTGTGGATCCAGTCACCTCTGAACATGAACTGACATGTCAGGCTGAGGG       CTACCCCAAGGCCGAAGTCATCTGGACAAGCAGTGACCATCAAGTCCTGAGTGGTAAGACCACCACCA       CCAATTCCAAGAGAGAGGAGAAGCTTTTCAATGTGACCAGCACACTGAGAATCAACACAACAACTAAT       GAGATTTTCTACTGCACTTTTAGGAGATTAGATCCTGAGGAAAACCATACAGCTGAATTGGTCATCCC       AGAACTACCTCTGGCACATCCTCCAAATGAAAGGACTCACTTGGTAATTCTGGGAGCCATCTTATTAT       GCCTTGGTGTAGCACTGACATTCATCTTCCGTTTAAGAAAAGGGAGAATGATGGATGTGAAAAAATGT       GGCATCCAAGATACAAACTCAAAGAAGCAAAGTGATACACATTTGGAGGAGACG TAA   A                                                   NOV35a, CG56110-03   SEQ ID NO:835   290 aa   MW at 33275.0 kD               Protein Sequence                     MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFV           HGEEDLKVQHSSYRQHARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNK       INQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTN       EIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKC       GIQDTNSKKQSDTHLEET                                     NOV35b, CG56110-07   SEQ ID NO:837   720 bp           DNA Sequence   ORF Start: ATG at 3   ORF Stop: TAG at 510                       TC   ATG ACCTACTGGCATTTGCTGAACGCATTTACTGTCACGGTTCCCAAGGACCTATATGTGGTAGAG           TATGGTAGCAATATGACAATTGAATGCAAATTCCCAGTAGAAAAACAATTAGACCTGGCTGCACTAAT       TGTCTATTGGGAAATGGAGGATAAGAACATTATTCAATTTGTGCATGGAGAGGAAGACCTGAAGGTTC       AGCATAGTAGCTACAGACAGAGGGCCCGGCTGTTGAAGGACCAGCTCTCCCTGGGAAATGCTGCACTT       CAGATCACAGATGTGAAATTGCAGGATGCAGGGGTGTACCGCTGCATGATCAGCTATGGTGGTGCCGA       CTACAAGCGAATTACTGTGAAAGTCAATGCCCCATACAACAAAATCAACCAAAGAATTTTGGTTGTGG       ATCCAGTCACCTCTGAACATGAACTGACATGTCAGGCTGAGGGCTACCCCAAGGCCGAAGTCATCTGG       ACAAGCAGTGACCATCAAGTCCTGAGTGGAGAT TAG   ATCCTGAGGAAAACCATACAGCTGAATTGGTC           ATCCCAGAACTACCTCTGGCACATCCTCCAAATGAAAGGACTCACTTGGTAATTCTGGGAGCCATCTT           ATTATGCCTTGGTGTAGCACTGACATTCATCTTCCGTTTAAGAAAAGGGAGAATGATGGATGTGAAAA           AATGTGGCATCCAAGATACAAACTCAAAGAAGCAAAGTGG                                                   NOV35b, CG56110-07   SEQ ID NO:838   169 aa   MW at 19327.9 kD               Protein Sequence                     MTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQ           HSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVD       PVTSEHELTCQAEGYPKARVIWTSSDHQVLSGD                                     NOV35c, 274082305   SEQ ID NO:839   900 bp           DNA Sequence   ORF Start: at 2   ORF Stop: TAA at 887                       C ACCAGATCTCCCACCATGAGGATATTTGCTGTCTTTATATTCATGACCTACTGGCATTTGCTGAACG           CATTTACTGTCACGGTTCCCAAGGACCTATATGTGGTAGAGTATGGTAGCAATATGACAATTGAATGC       AAATTCCCAGTAGAAAAACAATTAGACCTGGCTGCACTAATTGTCTATTGGGAAATGGAGGATAAGAA       CATTATTCAATTTGTGCATGGAGAGGAAGACCTGAAGGTTCAGCATAGTAGCTACAGACAGAGGGCCC       GGCTGTTGAAGGACCAGCTCTCCCTGGGAAATGCTGCACTTCAGATCACAGATGTGAAATTGCAGGAT       GCAGGGGTGTACCGCTGCATGATCAGCTATGGTGGTGCCGACTACAAGCGAATTACTGTGAAAGTCAA       TGCCCCATACAACAAAATCAACCAAAGAATTTTGGTTGTGGATCCAGTCACCTCTGAACATGAACTGA       CATGTCAGGCTGAGGGCTACCCCAAGGCCGAAGTCATCTGGACAAGCAGTGACCATCAAGTCCTGAGT       GGTAAGACCACCACCACCAATTCCAAGAGAGAGGAGAAGCTTTTCAATGTGACCAGCACACTGAGAAT       CAACACAACAACTAATGAGATTTTCTACTGCACTTTTAGGAGATTAGATCCTGAGGAAAACCATACAG       CTGAATTGGTCATCCCAGAACTACCTCTGGCACATCCTCCAAATGAAAGGACTCACTTGGTAATTCTG       GGAGCCATCTTATTATGCCTTGGTGTAGCACTGACATTCATCTTCCGTTTAAGAAAAGGGAGAATGAT       GGATGTGAAAAAATGTGGCATCCAAGATACAAACTCAAAGAAGCAAAGTGATACACATTTGGAGGAGA       CG TAA   AGTCGACGGCC                                                   NOV35c, 274082305   SEQ ID NO:840   295 aa   MW at 33817.6 kD               Protein Sequence                     TRSPTMRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKN           IIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVN       APYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRI       NTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMM       DVKKCGIQDTNSKKQSDTHLEET                                     NOV35d, CG56110-01   SEQ ID NO:841   873 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAA at 871                       ATG AGGATATTTGCTGTCTTTATATTCATGACCTACTGGCATTTGCTGAACGCATTTACTGTCACGGT           TCCCAAGGACCTATATGTGGTAGAGTATGGTAGCAATATGACAATTGAATGCAAATTCCCAGTAGAAA       AACAATTAGACCTGGCTGCACTAATTGTCTATTGGGAAATGGAGGATAAGAACATTATTCAATTTGTG       CATGGAGAGGAAGACCTGAAGGTTCAGCATAGTAGCTACAGACAGAGGGCCCGGCTGTTGAAGGACCA       GCTCTCCCTGGGAAATGCTGCACTTCAGATCACAGATGTGAAATTGCAGGATGCAGGGGTGTACCGCT       GCATGATCAGCTATGGTGGTGCCGACTACAAGCGAATTACTGTGAAAGTCAATGCCCCATACAACAAA       ATCAACCAAAGAATTTTGGTTGTGGATCCAGTCACCTCTGAACATGAACTGACATGTCAGGCTGAGGG       CTACCCCAAGGCCGAAGTCATCTGGACAAGCAGTGACCATCAAGTCCTGAGTGGTAAGACCACCACCA       CCAATTCCAAGAGAGAGGAGAAGCTTTTCAATGTGACCAGCACACTGAGAATCAACACAACAACTAAT       GAGATTTTCTACTGCACTTTTAGGAGATTAGATCCTGAGGAAAACCATACAGCTGAATTGGTCATCCC       AGAACTACCTCTGGCACATCCTCCAAATGAAAGGACTCACTTGGTAATTCTGGGAGCCATCTTATTAT       GCCTTGGTGTAGCACTGACATTCATCTTCCGTTTAAGAAAAGGGAGAATGATGGATGTGAAAAAATGT       GGCATCCAAGATACAAACTCAAAGAAGCAAAGTGATACACATTTGGAGGAGACG TAA                                                   NOV35d, CG56110-01   SEQ ID NO:842   290 aa   MW at 33275.0 kD               Protein Sequence                     MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFV           HGEEDLKVQHSSYRQRAELLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNK       INQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTN       EIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRNMDVKKC       GIQDTNSKKQSDTHLEET                                     NOV35e, CG56110-02   SEQ ID NO:843   666 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     TTTACTGTCACGGTTCCCAAGGACCTATATGTGGTAGAGTATGGTAGCAATATGACAATTGAATGCAA           ATTCCCAGTAGAAAAACAATTAGACCTGGCTGCACTAATTGTCTATTGGGAAATGGAGGATAAGAACA       TTATTCAATTTGTGCATGGAGAGGAAGACCTGAAGGTTCAGCATAGTAGCTACAGACAGAGGGCCCGG       CTGTTGAAGGACCAGCTCTCCCTGGGAAATGCTGCACTTCAGATCACAGATGTGAAATTGCAGGATGC       AGGGGTGTACCGCTGCATGATCAGCTATGGTGGTGCCGACTACAAGCGAATTACTGTGAAAGTCAATG       CCCCATACAACAAAATCAACCAAAGAATTTTGGTTGTGGATCCAGTCACCTCTGAACATGAACTGACA       TGTCAGGCTGAGGGCTACCCCAAGGCCGAAGTCATCTGGACAAGCAGTGACCATCAAGTCCTGAGTGG       TAAGACCACCACCACCAATTCCAAGAGAGAGGAGAAGCTTTTCAATGTGACCAGCACACTGAGAATCA       ACACAACAACTAATGAGATTTTCTACTGCACTTTTAGGAGATTAGATCCTGAGGAAAACCATACAGCT       GAATTGGTCATCCCAGAACTACCTCTGGCACATCCTCCAAATGAAAGGACTCAC                                                 NOV35e, CG56110-02   SEQ ID NO:844   222 aa   MW at 25431.6 kD               Protein Sequence                     FTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRAR           LLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELT       CQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTA       ELVIPELPLAHPPNERTH                                             NOV35f, CG56110-04   SEQ ID NO:845   745 bp               DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAG at 535                       ATG AGGATATTTGCTGTCTTTATATTCATGACCTACTGGCATTTGCTGAACGCATTTACTGTCACGGT           TCCCAAGGACCTATATGTGGTAGAGTATGGTAGCAATATGACAATTGAATGCAAATTCCCAGTAGAAA       AACAATTAGACCTGGCTGCACTAATTGTCTATTGGGAAATGGAGGATAAGAACATTATTCAATTTGTG       CATGGAGAGGAAGACCTGAAGGTTCAGCATAGTAGCTACAGACAGAGGGCCCGGCTGTTGAAGGACCA       GCTCTCCCTGGGAAATGCTGCACTTCAGATCACAGATGTGAAATTGCAGGATGCAGGGGTGTACCGCT       GCATGATCAGCTATGGTGGTGCCGACTACAAGCGAATTACTGTGAAAGTCAATGCCCCATACAACAAA       ATCAACCAAAGAATTTTGGTTGTGGATCCAGTCACCTCTGAACATGAACTGACATGTCAGGCTGAGGG       CTACCCCAAGGCCGAAGTCATCTGGACAAGCAGTGACCATCAAGTCCTGAGTGGAGAT TAG   ATCCTGA           GGAAAACCATACAGCTGAATTGGTCATCCCAGAACTACCTCTGGCACATCCTCCAAATGAAAGGACTC           ACTTGGTAATTCTGGGAGCCATCTTATTATGCCTTGGTGTAGCACTGACATTCATCTTCCGTTTAAGA           AAAGGGAGAATGATGGATGTGAAAAAATGTGGCATCCAAGATACAAACTCAAAGAAGCAAAGTGG                                                   NOV35f, CG56110-04   SEQ ID NO:846   178 aa   MW at 20453.3 kD               Protein Sequence                     MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFV           HGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNK       INQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGD                                     NOV35g, CG56110-05   SEQ ID NO:847   7184 bp           DNA Sequence   ORF Start: ATG at 62   ORF Stop: TAA at 932                       GCAGCTTCCCGAGGCTCCGCACCAGCCGCGCTTCTGTCCGCCTGCAGGGCATTCCAGAAAG   ATG AGGA           TATTTGCTGTCTTTATATTCATGACCTACTGGCATTTGCTGAACGCATTTACTGTCACGGTTCCCAAG       GACCTATATGTGGTAGAGTATGGTAGCAATATGACAATTGAATGCAAATTCCCAGTAGAAAAACAATT       AGACCTGGCTGCACTAATTGTCTATTGGGAAATGGAGGATAAGAACATTATTCAATTTGTGCATGGAG       AGGAAGACCTGAAGGTTCAGCATAGTAGCTACAGACAGAGGGCCCGGCTGTTGAAGGACCAGCTCTCC       CTGGGAAATGCTGCACTTCAGATCACAGATGTGAAATTGCAGGATGCAGGGGTGTACCGCTGCATGAT       CAGCTATGGTGGTGCCGACTACAAGCGAATTACTGTGAAAGTCAATGCCCCATACAACAAAATCAACC       AAAGAATTTTGGTTGTGGATCCAGTCACCTCTGAACATGAACTGACATGTCAGGCTGAGGGCTACCCC       AAGGCCGAAGTCATCTGGACAAGCAGTGACCATCAAGTCCTGAGTGGTAAGACCACCACCACCAATTC       CAAGAGAGAGGAGAAGCTTTTCAATGTGACCAGCACACTGAGAATCAACACAACAACTAATGAGATTT       TCTACTGCACTTTTAGGAGATTAGATCCTGAGGAAAACCATACAGCTGAATTGGTCATCCCAGAACTA       CCTCTGGCACATCCTCCAAATGAAAGGACTCACTTGGTAATTCTGGGAGCCATCTTATTATGCCTTGG       TGTAGCACTGACATTCATCTTCCGTTTAAGAAAAGGGAGAATGATGGATGTGAAAAAATGTGGCATCC       AAGATACAAACTCAAAGAAGCAAAGTGATACACATTTGGAGGAGACG TAA   TCCAGCATTGGAACTTCT           GATCTTCAAGCAGGGATTCTCAACCTGTGGTTTAGGGGTTCATCGGGGCTGAGCGTGACAAGAGGAAG           GAATGGGCCCGTGGGATGCAGGCAATGTGGGACTTAAAAGGCCCAAGCACTGAAAATGGAACCTGGCG           AAAGCAGAGGAGGAGAATGAAGAAAGATGGAGTCAAACAGGGAGCCTGGAGGGAGACCTTGATACTTT           CAAATGCCTGAGGGGCTCATCGACGCCTGTGACAGGGAGAAAGGATACTTCTGAACAAGGAGCCTCCA           AGCAAATCATCCATTGCTCATCCTAGGAAGACGGGTTGAGAATCCCTAATTTGAGGGTCAGTTCCTGC           AGAAGTGCCCTTTGCCTCCACTCAATGCCTCAATTTGTTTTCTGCATGACTGAGAGTCTCAGTGTTGG           AACGGGACAGTATTTATGTATGAGTTTTTCCTATTTATTTTGAGTCTGTGAGGTCTTCTTGTCATGTG           AGTGTGGTTGTGAATGATTTCTTTTGAAGATATATTGTAGTAGATGTTACAATTTTGTCGCCAAACTA           AACTTGCTGCTTAATGATTTGCTCACATCTAGTAAAACATGGAGTATTTGTAAGGTGCTTGGTCTCCT           CTATAACTACAAGTATACATTGGAAGCATAAAGATCAAACCGTTGGTTGCATAGGATGTCACCTTTAT           TTAACCCATTAATACTCTGGTTGACCTAATCTTATTCTCAGACCTCAAGTGTCTGTGCAGTATCTGTT           CCATTTAAATATCAGCTTTACAATTATGTGGTAGCCTACACACATAATCTCATTTCATCGCTGTAACC           ACCCTGTTGTGATAACCACTATTATTTTACCCATCGTACAGCTGAGGAAGCAAACAGATTAAGTAACT           TGCCCAAACCAGTAAATAGCAGACCTCAGACTGCCACCCACTGTCCTTTTATAATACAATTTACAGCT           ATATTTTACTTTAAGCAATTCTTTTATTCAAAAACCATTTATTAAGTGCCCTTGCAATATCAATCGCT           GTGCCAGGCATTGAATCTACAGATGTGAGCAAGACAAAGTACCTGTCCTCAAGGAGCTCATAGTATAA           TGAGGAGATTAACAAGAAAATGTATTATTACAATTTAGTCCAGTGTCATAGCATAAGGATGATGCGAG           GGGAAAACCCGAGCAGTGTTGCCAAGAGGAGGAAATAGGCCAATGTGGTCTGGGACGGTTGGATATAC           TTAAACATCTTAATAATCAGAGTAATTTTCATTTACAAAGAGAGGTCGGTACTTAAAATAACCCTGAA           AAATAACACTGGAATTCCTTTTCTAGCATTATATTTATTCCTGATTTGCCTTTGCCATATAATCTAAT           GCTTGTTTATATAGTGTCTGGTATTGTTTAACAGTTCTGTCTTTTCTATTTAAATGCCACTAAATTTT           AAATTCATACCTTTCCATGATTCAAAATTCAAAAGATCCCATGGGAGATGGTTGGAAAATCTCCACTT           CATCCTCCAAGCCATTCAAGTTTCCTTTCCAGAAGCAACTGCTACTGCCTTTCATTCATATGTTCTTC           TAAAGATAGTCTACATTTGGAAATGTATGTTAAAAGCACGTATTTTTAAAATTTTTTTCCTAAATAGT           AACACATTGTATGTCTGCTGTGTACTTTGCTATTTTTATTTATTTTAGTGTTTCTTATATAGCAGATG           GAATGAATTTGAAGTTCCCAGGGCTGAGGATCCATGCCTTCTTTGTTTCTAAGTTATCTTTCCCATAC           CTTTTCATTATCTTTCATATGATCCAGTATATGTTAAATATGTCCTACATATACATTTAGACAACCAC           CATTTGTTAAGTATTTGCTCTAGGACAGAGTTTGGATTTGTTTATGTTTGCTCAAAAGGAGACCCATG           GGCTCTCCAGGGTGCACTGAGTCAATCTAGTCCTAAAAAGCAATCTTATTATTAACTCTGTATGACAG           AATCATGTCTGGAACTTTTGTTTTCTGCTTTCTGTCAAGTATAAACTTCACTTTGATGCTGTACTTGC           AAAATCACATTTTCTTTCTGGAAATTCCGGCAGTGTACCTTGACTGCTAGCTACCCTGTGCCAGAAAA           GCCTCATTCGTTGTGCTTGAACCCTTGAATGCCACCAGCTGTCATCACTACACAGCCCTCCTAAGAGC           CTTCCTGGAGGTTTCGAGATTCAGATGCCCTGGGAGATCCCAGAGTTTCCTTTCCCTCTTGGCCATAT           TCTGGTGTCAATGACAAGGAGTACCTTGGCTTTGCCACATGTCAAGGCTGAAGAAACAGTGTCTCCAA           CAGAGCTCCTTGTGTTATCTGTTTGTACATGTGCATTTGTACAGTAATTGGTGTGACAGTGTTCTTTG           TGTGAATTACAGGCAAGAATTGTGGCTGAGCAAGGCACATAGTCTACTCAGTCTATTCCTAAGTCCTA           ACTCCTCCTTGTGGTGTTGGATTTGTAAGGCACTTTATCCCTTTTGTCTCATGTTTCATCGTAAATGG           CATAGGCAGAGATGATACCTAATTCTGCATTTGATTGTCACTTTTTGTACCTGCATTAATTTAATAAA           ATATTCTTATTTATTTTGTTACTTGGTAAAAAAAAAAAAAAAGCTTCCCGAGGCTCCGCACCAGCCGC           GCTTCTGTCCGCCTGCAGGGCATTCCAGAAAGATGAGGATATTTGCTGTCTTTATATTCATGACCTAC           TGGCATTTGCTGAACGCATTTACTGTCACGGTTCCCAAGGACCTATATGTGGTAGAGTATGGTAGCAA           TATGACAATTGAATGCAAATTCCCAGTAGAAAAACAATTAGACCTGGCTGCACTAATTGTCTATTGGG           AAATGGAGGATAAGAACATTATTCAATTTGTGCATGGAGAGGAAGACCTGAAGGTTCAGCATAGTAGC           TACAGACAGAGGGCCCGGCTGTTGAAGGACCAGCTCTCCCTGGGAAATGCTGCACTTCAGATCACAGA           TGTGAAATTGCAGGATGCAGGGGTGTACCGCTGCATGATCAGCTATGGTGGTGCCGACTACAAGCGAA           TTACTGTGAAAGTCAATGCCCCATACAACAAAATCAACCAAAGAATTTTGGTTGTGGATCCAGTCACC           TCTGAACATGAACTGACATGTCAGGCTGAGGGCTACCCCAAGGCCGAAGTCATCTGGACAAGCAGTGA           CCATCAAGTCCTGAGTGGTAAGACCACCACCACCAATTCCAAGAGAGAGGAGAAGCTTTTCAATGTGA           CCAGCACACTGAGAATCAACACAACAACTAATGAGATTTTCTACTGCACTTTTAGGAGATTAGATCCT           GAGGAAAACCATACAGCTGAATTGGTCATCCCAGAACTACCTCTGGCACATCCTCCAAATGAAAGGAC           TCACTTGGTAATTCTGGGAGCCATCTTATTATGCCTTGGTGTAGCACTGACATTCATCTTCCGTTTAA           GAAAAGGGAGAATGATGGATGTGAAAAAATGTGGCATCCAAGATACAAACTCAAAGAAGCAAAGTGAT           ACACATTTGGAGGAGACGTAATCCAGCATTGGAACTTCTGATCTTCAAGCAGGGATTCTCAACCTGTG           GTTTAGGGGTTCATCGGGGCTGAGCGTGACAAGAGGAAGGAATGGACCCGTGGGATGCAGGCAATGTG           GGACTTAAAAGGCCCAAGCACTGAAAATGGAACCTGGCGAAAGCAGAGGAGGAGAATGAAGAAAGATG           GAGTCAAACAGGGAGCCTGGAGGGAGACCTTGATACTTTCAAATGCCTGAGGGGCTCATCGACGCCTG           TGACAGGGAGAAAGGATACTTCTGAACAAGGAGCCTCCAAGCAAATCATCCATTGCTCATCCTAGGAA           GACGGGTTGAGAATCCCTAATTTGAGGGTCAGTTCCTGCAGAAGTGCCCTTTGCCTCCACTCAATGCC           TCAATTTGTTTTCTGCATGACTGAGAGTCTCAGTGTTGGAACGGGACAGTATTTATGTATGAGTTTTT           CCTATTTATTTTGAGTCTGTGAGGTCTTCTTGTCATGTGAGTGTGGTTGTGAATGATTTCTTTTGAAC           ATATATTGTAGTAGATGTTACAATTTTGTCGCCAAACTAAACTTGCTGCTTAATGATTTGCTCACATC           TAGTAAAACATGGAGTATTTGTAAGGTGCTTGGTCTCCTCTATAACTACAAGTATACATTGGAAGCAT           AAAGATCAAACCGTTGGTTGCATAGGATGTCACCTTTATTTAACCCATTAATACTCTGGTTGACCTAA           TCTTATTCTCAGACCTCAAGTGTCTGTGCAGTATCTGTTCCATTTAAATATCAGCTTTACAATTATGT           GGTAGCCTACACACATAATCTCATTTCATCGCTGTAACCACCCTGTTGTGATAACCACTATTATTTTA           CCCATCGTACAGCTGAGGAAGCAAACAGATTAAGTAACTTGCCCAAACCAGTAAATAGCAGACCTCAG           ACTGCCACCCACTGTCCTTTTATAATACAATTTACAGCTATATTTTACTTTAAGCAATTCTTTTATTC           AAAAACCATTTATTAAGTGCCCTTGCAATATCAATCGCTGTGCCAGGCATTGAATCTACAGATGTGAG           CAAGACAAAGTACCTGTCCTCAAGGAGCTCATAGTATAATCAGGAGATTAACAAGAAAATGTATTATT           ACAATTTAGTCCAGTGTCATAGCATAAGGATGATGCGAGGGGAAAACCCGAGCAGTGTTGCCAAGAGC           AGGAAATAGGCCAATGTGGTCTGGGACGGTTGGATATACTTAAAGATCTTAATAATCAGAGTAATTTT           CATTTACAAAGAGAGGTCGGTACTTAAAATAACCCTGAAAAATAACACTGGAATTCCTTTTCTAGCAT           TATATTTATTCCTGATTTGCCTTTGCCATATAATCTAATGCTTGTTTATATAGTGTCTGGTATTGTTT           AACAGTTCTGTCTTTTCTATTTAAATGCCACTAAATTTTAAATTCATACCTTTCCATGATTCAAAATT           CAAAAGATCCCATGGGAGATGGTTGGAAAATCTCCACTTCATCCTCCAAGCCATTCAAGTTTCCTTTC           CAGAAGCAACTGCTACTGCCTTTCATTCATATGTTCTTCTAAAGATAGTCTACATTTGGAAATGTATG           TTAAAAGCACGTATTTTTAAAATTTTTTTCCTAAATAGTAACACATTGTATGTCTGCTGTGTACTTTC           CTATTTTTATTTATTTTAGTGTTTCTTATATAGCAGATGGAATGAATTTGAAGTTCCCAGGGCTGAGG           ATCCATGCCTTCTTTGTTTCTAAGTTATCTTTCCCATAGCTTTTCATTATCTTTCATATGATCCAGTA           TATGTTAAATATGTCCTACATATACATTTAGACAACCACCATTTGTTAAGTATTTGCTCTAGGACAGA           GTTTGGATTTGTTTATGTTTGCTCAAAAGGAGACCCATGGGCTCTCCAGGGTGCACTGAGTCAATCTA           GTCCTAAAAAGCAATCTTATTATTAACTCTGTATGACAGAATCATGTCTGGAACTTTTGTTTTCTGCT           TTCTGTCAAGTATAAACTTCACTTTGATGCTGTACTTGCAAAATCACATTTTCTTTCTGGAAATTCCG           GCAGTGTACCTTGACTGCTAGCTACCCTGTGCCAGAAAAGCCTCATTCGTTGTGCTTGAACCCTTGAA           TGCCACCAGCTGTCATCACTACACAGCCCTCCTAAGAGGCTTCCTGGAGGTTTCGAGATTCAGATGCC           CTGGGAGATCCCAGAGTTTCCTTTCCCTCTTGGCCATATTCTGGTGTCAATGACAAGGAGTACCTTGG           CTTTGCCACATGTCAAGGCTGAAGAAACAGTGTCTCCAACAGAGCTCCTTGTGTTATCTGTTTGTACA           TGTGCATTTGTACAGTAATTGGTGTGACAGTGTTCTTTGTGTGAATTACAGGCAAGAATTGTGGCTGA           GCAAGGCACATAGTCTACTCAGTCTATTCCTAAGTCCTAACTCCTCCTTGTGGTGTTGGATTTGTAAG           GCACTTTATCCCTTTTGTCTCATGTTTCATCGTAAATGGCATAGGCAGAGATGATACCTAATTCTGCA           TTTGATTGTCACTTTTTGTACCTGCATTAATTTAATAAAATATTCTTATTTATTTTGTTACTTGGTAC           ACCAGCATGTCCATTTTCTTGTTTATTTTGTGTTTAATAAAATG                                                   NOV35g, CG56110-05   SEQ ID NO:848   290 aa   MW at 33275.0 kD               Protein Sequence                     MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFV           HGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNK       INQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTN       EIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKC       GIQDTNSKKQSDTHLEET                                     NOV35h, CG56110-06   SEQ ID NO:849   900 bp           DNA Sequence   ORF Start: ATG at 17   ORF Stop: at 866                       CACCAGATCTCCCACC   ATG AGGATATTTGCTGTCTTTATATTCATGACCTACTGGCATTTGCTGAACG           CATTTACTGTCACGGTTCCCAAGGACCTATATGTGGTAGAGTATGGTAGCAATATGACAATTGAATGC       AAATTCCCAGTAGAAAAACAATTAGACCTGGCTGCACTAATTGTCTATTGGGAAATGGAGGATAAGAA       CATTATTCAATTTGTGCATGGAGAGGAAGACCTGAAGGTTCAGCATAGTAGCTACAGACAGAGGGCCC       GGCTGTTGAAGGACCAGCTCTCCCTGGGAAATGCTGCACTTCAGATCACAGATGTGAAATTGCAGGAT       GCAGGGGTGTACCGCTGCATGATCAGCTATGGTGGTGCCGACTACAAGCGAATTACTGTGAAAGTCAA       TGCCCCATACAACAAAATCAACCAAAGAATTTTGGTTGTGGATCCAGTCACCTCTGAACATGAACTGA       CATGTCAGGCTGAGGGCTACCCCAAGGCCGAAGTCATCTGGACAAGCAGTGACCATCAAGTCCTGAGT       GGTAAGACCACCACCACCAATTCCAAGAGAGAGGAGAAGCTTTTCAATGTGACCAGCACACTGAGAAT       CAACACAACAACTAATGAGATTTTCTACTGCACTTTTAGGAGATTAGATCCTGAGGAAAACCATACAG       CTGAATTGGTCATCCCAGAACTACCTCTGGCACATCCTCCAAATGAAAGGACTCACTTGGTAATTCTG       GGAGCCATCTTATTATGCCTTGGTGTAGCACTGACATTCATCTTCCGTTTAAGAAAAGGGAGAATGAT       GGATGTGAAAAAATGTGGCATCCAAGATACAAACTCAAAGAAGCAAAGTGAT ACACATTTGGAGGAGA           CGTAAAGTCGACGGCC                                                   NOV35h, CG56110-06   SEQ ID NO:850   283 aa   MW at 32449.2 kD               Protein Sequence                     MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFV           HGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNK       INQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTN       EIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKC       GIQDTNSKKQS                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 35B.  
               TABLE 35B                       Comparison of the NOV35 protein sequences.                                                NOV35a   -----MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIV   (SEQ ID NO:836)                   NOV35b   --------------MTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIV   (SEQ ID NO:838)               NOV35c   TRSPTMRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIV   (SEQ ID NO:840)               NOV35d   -----MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIV   (SEQ ID NO:842)               NOV35e   -----------------------FTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIV   (SEQ ID NO:844)               NOV35f   -----MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIV   (SEQ ID NO:846)               NOV35g   -----MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIV   (SEQ ID NO:848)               NOV35h   -----MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIV   (SEQ ID NO:850)               NOV35a   YWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCM               NOV35b   YWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCM               NOV35c   YWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCM               NOV35d   YWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCM               NOV35e   YWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCM               NOV35f   YWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCM               NOV35g   YWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCM               NOV35h   YWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCM               NOV35a   ISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVL               NOV35b   ISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVL               NOV35c   ISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVL               NOV35d   ISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVL               NOV35e   ISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVL               NOV35f   ISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVL               NOV35g   ISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVL               NOV35h   ISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVL               NOV35a   SGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPP               NOV35b   SGD---------------------------------------------------------               NOV35c   SGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPP               NOV35d   SGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPP               NOV35e   SGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPP               NOV35f   SGD---------------------------------------------------------               NOV35g   SGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPP               NOV35h   SGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPP               NOV35a   NERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET               NOV35b   -------------------------------------------------------               NOV35c   NERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET               NOV35d   NERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET               NOV35e   NERTH--------------------------------------------------               NOV35f   -------------------------------------------------------               NOV35g   NERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET               NOV35h   NERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQS-------                  
 
      Further analysis of the NOV35a protein yielded the following properties shown in Table 35C.  
               TABLE 35C                       Protein Sequence Properties NOV35a                                        SignalP analysis:   Cleavage site between residues 19 and 20       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 2; pos. chg 1; neg. chg 0           H-region:   length 22; peak value 13.04           PSG score:   8.64                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −3.72           possible cleavage site: between 18 and 19                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 2           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 242-258               −11.36                             PERIPHERAL   Likelihood = 7.90 (at 40)                         ALOM score: −11.36 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 249           Charge difference: 5.0 C(5.0)-N(0.0)           C &gt; N: C-terminal side will be inside                 &gt;&gt;&gt;Caution: Inconsistent mtop result with signal peptide       &gt;&gt;&gt; Single TMS is located near the C-terminus       &gt;&gt;&gt; membrane topology: type Nt (cytoplasmic tail 1 to 241)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   1   Hyd Moment(75):   5.40           Hyd Moment(95):   9.37   G content:   0           D/E content:   1   S/T content:   3                         Score: −2.89       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 12 MRI|FA                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 11.7%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: RIFA                 none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: found                         LL at 15           LL at 87                 checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 94.1       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         30.4%: nuclear           26.1%: cytoplasmic           13.0%: Golgi           13.0%: endoplasmic reticulum            8.7%: mitochondrial            4.3%: vesicles of secretory system            4.3%: peroxisomal                 &gt;&gt; prediction for CG56110-03 is nuc (k = 23)                  
 
      A search of the NOV35a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 35D.  
               TABLE 35D                          Geneseq Results for NOV35a                                         NOV35a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #,Date]   Residues   Region   Value               AAE33390   Human membrane B7-4 (B7-4M)   1 . . . 290   290/290 (100%)   e−169           protein -  Homo sapiens , 290 aa.   1 . . . 290   290/290 (100%)           [WO200279499-A1, 10-OCT-2002]       ABJ18518   Human PD-L1M protein -  Homo     1 . . . 290   290/290 (100%)   e−169             sapiens , 290 aa. [WO200278731-A1,   1 . . . 290   290/290 (100%)           10-OCT-2002]       AAE16964   Human PD-1 ligand (PD-L1) -  Homo     1 . . . 290   290/290 (100%)   e−169             sapiens , 290 aa. [WO200200730-A2,   1 . . . 290   290/290 (100%)           03-JAN-2002]       AAU81007   B7-related protein, BSL1 -  Homo     1 . . . 290   290/290 (100%)   e−169             sapiens , 290 aa. [WO200194413-A2,   1 . . . 290   290/290 (100%)           13-DEC-2001]       ABG64016   Human albumin fusion protein #691 -   1 . . . 290   290/290 (100%)   e−169             Homo sapiens , 290 aa.   1 . . . 290   290/290 (100%)           [WO200177137-A1, 18-OCT-2001]                  
 
      In a BLAST search of public sequence databases, the NOV35a protein was found to have homology to the proteins shown in the BLASTP data in Table 35E.  
               TABLE 35E                          Public BLASTP Results for NOV35a                                         NOV35a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q9NZQ7   B7-H1 (PD-1-ligand precursor) -   1 . . . 290   290/290 (100%)   e−168             Homo sapiens  (Human), 290 aa.   1 . . . 290   290/290 (100%)       CAC34696   Sequence 1 from Patent   1 . . . 227   227/227 (100%)   e−130           WO0114557 -  Homo sapiens     1 . . . 227   227/227 (100%)           (Human), 245 aa.       Q9EP73   PD-1-ligand precursor (B7-H1   1 . . . 290   202/291 (69%)    e−114           protein) -  Mus musculus  (Mouse),   1 . . . 290   236/291 (80%)            290 aa.       Q9NUZ5   Hypothetical protein FLJ11032 -   115 . . . 290    176/176 (100%)   7e−99              Homo sapiens  (Human), 176 aa.   1 . . . 176   176/176 (100%)       Q9BQ51   Butyrophilin precursor B7-DC (PD-   19 . . . 240    90/223 (40%)   2e−35            1-ligand 2 protein) -  Homo sapiens     21 . . . 218    123/223 (54%)            (Human), 273 aa.                  
 
      PFam analysis predicts that the NOV35a protein contains the domains shown in the Table 35F.  
               TABLE 35F                          Domain Analysis of NOV35a                                             Identities/               Pfam   NOV35a   Similarities for   Expect           Domain   Match Region   the Matched Region   Value                       ig   33 . . . 116   13/85 (15%)   0.13                   54/85 (64%)                      
 
     Example 36  
      The NOV36 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 36A.  
               TABLE 36A                       NOV36 Sequence Analysis                                                NOV36a, CG56383-02   SEQ ID NO:851   2715 bp           DNA Sequence   ORF Start: ATG at 34   ORF Stop: TAA at 2566                       TGCCTGCACTGCAAGTGTCCCCAGGAGGAGCAC   ATG GTGACAGTGATGCCGCTGGAGATGGAGAAGAC           CATCAGCAAACTCATGTTTGACTTTCAGAGGAACTCGACCTCAGATGATGACTCAGGCTGTGCTTTGG       AAGAGTATGCCTGGGTCCCGCCGGGTCTGAAGCCTGAACAGGTACACCAGTACTATAGCTGTCTCCCA       GAAGAGAAAGTCCCTTATGTCAACAGTCCTGGAGAGAAACTGCGAATCAAGCAGCTACTACACCAGCT       GCCGCCACATGACAATGAGGTAAGGTATTGCAACTCCCTGGATGAGGAAGAGAAGAGGGAGCTGAAGC       TTTTCAGCAGCCAGAGGAAACGCGAAAACTTGGGCCGCGGGAATGTCAGGCCTTTCCCAGTCACCATG       ACAGGAGCTATTTGTGAACAGTGCGGAGGCCAGATCAATGGTGGAGACATCGCTGTGTTTGCGTCACG       CGCTGGCCACGGCGTTTGCTGGCACCCGCCGTGCTTCGTATGCACTGTCTGCAATGAGCTCCTGGTGG       ATCTGATCTACTTTTACCAAGATGGGAAGATATACTGTGGCAGGCACCATGCTGAGTGCCTGAAGCCG       CGCTGTGCTGCCTGCGATGAGATCATCTTTGCAGATGAATGCACAGAAGCTGAGGGGCGACACTGGCA       CATGAAACACTTTTGCTGCTTCGAGTGTGAGACAGTGCTGGGCGGCCAGCGCTACATCATGAAGGAGG       GAAGACCCTACTGTTGCCACTGCTTCGAGTCCTTGTATGCAGAATATTGTGACACCTGTGCCCAACAT       ATAGGTATCGACCAAGGTCAAATGACCTATGATGGCCAACACTGGCATGCCACTGAGACCTGTTTCTG       CTGTGCTCACTGCAAGAAATCCCTCCTGGGGCGGCCATTCCTCCCGAAGCAGGGCCAGATATTCTGCT       CACGGGCCTGCAGTGCTGGGGAAGACCCCAATGGTTCTGACTCCTCTGATTCCGCCTTCCAGAACGCC       AGGGCCAAGGAGTCCCGGCGCAGTGCCAAAATTGGCAAGAACAAGGGCAAGACGGAGGAGCCCATGCT       GAACCAGCACAGCCAGCTGCAAGTGAGTTCTAACCGGCTGTCAGCCGACGTAGACCCCCTGTCACTGC       AGATGGACATGCTCAGCCTGTCCAGCCAGACACCCAGCCTCAACCGGGACCCCATCTGGAGGAGCCGG       GAAGAGCCCTACCATTATGGGAACAAGATGGAGCAGAACCAGACCCAGAGCCCTCTGCAGCTCCTCAG       CCAGTGCAACATCAGAACTTCCTACAGTCCAGGAGGGCAAGGGGCTGGGGCCCAGCCCGAAATGTGGG       GCAAGCACTTCAGCAACCCCAAAAGGAGCTCGTCACTGGCCATGACAGGACATGCTGGCAGCTTCATC       AAGGAATGCCGAGAAGACTATTACCCGGGGAGGCTGAGATCTCAGGAGAGCTACAGTGATATGTCTAG       TCAGAGTTTCAGTGAGACCCGAGGCAGCATCCAAGTCCCCAAATATGAGGAGGAAGAGGAAGAGGAAG       GGGGCTTGTCCACTCAGCAGTGTCGGACCCGTCATCCCATCAGTTCCCTGAAATACACAGAGGACATG       ACGCCCACAGAGCAGACCCCTCGGGGCTCCATGGAATCCCTGGCCCTGTCTAATGCAACAGGTCTCTC       TGCTGATGGTGGTGCCAAGCGCCAGGAGCACCTATCCCGATTTTCCATGCCTGACCTCAGCAAAGACT       CTGGAATGAATGTGTCTGAGAAGCTGAGCAACATGGGCACTCTTAACTCGTCCATGCAGTTCCGGAGC       GCAGAGTCAGTTCGCAGCCTGCTCTCTGCCCAGCAGTACCAGGAGATGGAGGGAAACCTCCACCAGCT       CAGCAACCCCATTGGCTACAGAGACCTGCAGTCCCACGGAAGGATGCATCAGAGCTTTGATTTTGATG       GAGGGATGGCGGGCAGCAAGCTGCCAGGGCAGGAGGGCGTGAGGATCCAGCCCATGAGTGAACGCACC       CGGAGAAGAGCTACTTCACGCGACGACAACCGCCGTTTCCGACCTCACAGGTCCAGGCGTTCCCGACG       CTCTCGCTCCGACAACGCCCTCCACCTGGCCAGCGAACGCGAGGCCATCTCCCGGTTAAAAGATAGGC       CCCCTCTGAGAGCCAGGGAGGACTATGACCAATTTATGCGCCAGCGGAGCTTCCAGGAGAGCATGGGG       CATGGGTCCCGGAGGGACCTGTACGGCCAGTGCCCTAGGACTGTGTCGGACCTGGCTTTGCAGAATGC       CTTTGGGGACCGCTGGGGACCCTACTTCGCCGAGTATGATTGGTGTTCCACCTGCTCCTCCTCTTCAG       AGTCTGACAACGAGGGCTATTTCCTAGGAGAACCCATCCCCCAGCCAGCGCGCCTGCGATACGTCACA       AGCGATGAGCTGCTGCACAAATACAGCTCCTACGGCCTCCCCAAATCTTCCACATTAGGTGGCAGAGG       ACAGTTGCACAGCAGGAAAAGACAGAAGAGCAAAAACTGTATCATTTCT TAA   TATGATTGGGATCAGG           GAATGGGAGAAGATGGGAGCTAAGAATGTAAAGTCAGAAACTTGCACTGTTTTAAATGTTAAAGCGCT           TTTGGGGGTGGCTTATGGGGGAGAAAAGGGAAAATGCTGTCAGTAGATGGAGGCAAGGTTACA                                           NOV36a, CG56383-02   SEQ ID NO:852   844 aa   MW at 95613.8 kD           Protein Sequence                     MVTVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVNSPG           EKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSSQRKRENLGRGNVRPFPVTMTGAICEQCGGQ       INGGDIAVFASRAGHGVCWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAACDEIIFA       DECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIGIDQGQMTYD       GQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSAFQNARAKESRRSAKI       GKNKGKTEEPMLNQHSQLQVSSNRLSADVDPLSLQMDMLSLSSQTPSLNRDPIWRSREEPYHYGNKME       QNQTQSPLQLLSQCNIRTSYSPGGQGAGAQPEMWGKHFSNPKRSSSLAMTGHAGSFIKECREDYYPGR       LRSQESYSDMSSQSFSETRGSIQVPKYEEEEEEEGGLSTQQCRTRHPISSLKYTEDMTPTEQTPRGSM       ESLALSNATGLSADGGAKRQEHLSRFSMPDLSKDSGMINSEKLSNMGTLNSSMQFRSAESVRSLLSAQ       QYQEMEGNLHQLSNPIGURDLQSHGRMHQSFDFDGGMAGSKLPGQEGVRIQPMSERTRRRATSRDDNR       RFRPHRSRRSRRSRSDNALHLASEREAISRLKDRPPLRAREDYDQFMRQRSFQESMGHGSRRDLYGQC       PRTVSDLALQNAFGDRWGPYFAEYDWCSTCSSSSESDNEGYFLGEPIPQPARLRYVTSDELLHKYSSY       GLPKSSTLGGRGQLHSRKRQKSKNCIIS                                     NOV36b, CG56383-01   SEQ ID NO:853   1190 bp           DNA Sequence   ORF Start: ATG at 54   ORF Stop: TGA at 1014                       TTATTGACAGTTTATCCTGCCGCACCTGGAATCCTGAGACAAACCAAGGTGCT   ATG TGTTTCACGTCC           CAGTGCAGAGCTCTGAGCAGCTCATCAGCCTCTCCAATGTCTCTCATTTTTTTAGGTATCGACCAAGG       TCAAATGACCTATGACGGCCAACACTGGCATGCCACTGAGACCTGTTTCTGCTGTGCTCACTGCAAGA       AATCCCTCCTGGGGCGGCCATTCCTCCCGAAGCAGGGCCAGATATTCTGCTCACGGGCCTGCAGTGCT       GGGGAAGACCCCAATGGTTCTGACTCCTCTGATTCCGCCTTCCAGAACGCCAGGGCCAAGGAGTCCCG       GCGCAGTGCCAAAATTGGCAAGAACAAGGGCAAGACGGAGGAGCCCATGCTGAACCAGCACAGCCAGC       TGCAAGTGAGTTCTAACCGGCTGTCAGCCGACGTAGACCCCCTGTCACTGCAGATGGACATGCTCAGC       CTGTCCAGCCAGACACCCAGCCTCAACCGGGACCCCATCTGGAGGAGCCGGGAAGAGCCCTACCATTA       AGGGAACAAGATGGAGCAGAACCAGACCCAGAGCCCTCTGCAGCTCCTCAGCCAGTGCAACATCAGAA       CTTCCTACAGTCCAGGAGGGCAAGGGGCTGGGGCCCAGCCCGAAATGTGGGGCAAGCACTTCAGCAAC       CCCAAAAGGAGCACGTCACTGGCCATGACAGGACATGCTGGCAGCTTCATCAAGGAATGCCGAGAAGA       CTATTACCCGGGGAGGCTGAGATCTCAGGAGAGCTACAGTGATATGTCTAGTCAGAGTTTCAGTGAGA       CCCGAGGCAGCATCCAAGTCCCCAAATATGAGGAGGAAGAGGAAGAGGAAGGGGGCTTGTCCACTCAG       CAGTGTCGGACCCGTCATCCCATCAGTTCCCTGAAATACACAGAGGACATGACGCCCACAGAGCAGAC       CCCTCGGGGCTCCATGGAATCCCTGGCCCTGTCTAATGCAACAGGTAGGTTCTGTTCACCT TGA   AAAC           AGATAGAAGGGGGTAGTCTCTGGGTGACTGGATGCTGGTCCCCAGGAATTTTTTTTTTTTTGAAATGG           AGTCTCGCTCTGTCCCCCAGGCTGGAGTGCAGTGGCACGATCTCCGCTCACTGCAAGCTCCACCTCCC           GGGTTCACGCCATTCTCCTGCCTCAGCCTCACGA                                           NOV36b, CG56383-01   SEQ ID NO:854   320 aa   MW at 35524.0 kD           Protein Sequence                     MCFTSQCRALSSSSASPMSLTFLGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCS           EACSAGEDPNGSDSSDSAFQNARAXESRRSAKIGKNKGKTEEPMLNQHSQLQVSSNRLSADVDPLSLQ       MDMLSLSSQTPSLNRDPIWRSREEPYHYGNKMEQNQTQSPLQLLSQCNIRTSYSPGGQGAGAQPEMWG       KHFSNPKRSTSLAMTGHAGSFIKECREDYYPGRLRSQESYSDMSSQSFSETRGSIQVPKYEEEEEEEG       GLSTQQCRTRHPISSLKYTEDMTPTEQTPRGSMESLALSNATGRFCSP                                     NOV36c, SNP13382513 of   SEQ ID NO:855   2715 bp           CG56383-02, DNA Sequence   ORF Start: ATG at 34   ORF Stop: TAA at 2566           SNP Pos: 989   SNP Change: C to T                       TGCCTGCACTGCAAGTGTCCCCAGGAGGAGCAC   ATG GTGACAGTGATGCCGCTGGAGATGGAGAAGAC           CATCAGCAAACTCATGTTTGACTTTCAGAGGAACTCGACCTCAGATGATGACTCAGGCTGTGCTTTGG       AAGAGTATGCCTGGGTCCCGCCGGGTCTGAAGCCTGAACAGGTACACCAGTACTATAGCTGTCTCCCA       GAAGAGAAAGTCCCTTATGTCAACAGTCCTGGAGAGAAACTGCGAATCAAGCAGCTACTACACCAGCT       GCCGCCACATGACAATGAGGTAAGGTATTGCAACTCCCTGGATGAGGAAGAGAAGAGGGAGCTGAAGC       TTTTCAGCAGCCAGAGGAAACGCGAAAACTTGGGCCGCGGGAATGTCAGGCCTTTCCCAGTCACCATG       ACAGGAGCTATTTGTGAACAGTGCGGAGGCCAGATCAATGGTGGAGACATCGCTGTGTTTGCGTCACG       CGCTGGCCACGGCGTTTGCTGGCACCCGCCGTGCTTCGTATGCACTGTCTGCAATGAGCTCCTGGTGG       ATCTGATCTACTTTTACCAAGATGGGAAGATATACTGTGGCAGGCACCATGCTGAGTGCCTGAAGCCG       CGCTGTGCTGCCTGCGATGAGATCATCTTTGCAGATGAATGCACAGAAGCTGAGGGGCGACACTGGCA       CATGAAACACTTTTGCTGCTTCGAGTGTGAGACAGTGCTGGGCGGCCAGCGCTACATCATGAAGGAGG       GAAGACCCTACTGTTGCCACTGCTTCGAGTCCTTGTATGCAGAATATTGTGACACCTGTGCCCAACAT       ATAGGTATCGACCAAGGTCAAATGACCTATGATGGCCAACACTGGCATGCCACTGAGACCTGTTTCTG       CTGTGCTCACTGCAAGAAATCCCTCCTGGGGCGGCCATTCCTCCCGAAGCAGGGCCAGATATTCTGCT       CACGGGCCTGCAGTGCTGGGGAAGACCCCAATGGTT   T   TGACTCCTCTGATTCCGCCTTCCAGAACGCC       AGGGCCAAGGAGTCCCGGCGCAGTGCCAAAATTGGCAAGAACAAGGGCAAGACGGAGGAGCCCATGCT       GAACCAGCACAGCCAGCTGCAAGTGAGTTCTAACCGGCTGTCAGCCGACGTAGACCCCCTGTCACTGC       AGATGGACATGCTCAGCCTGTCCAGCCAGACACCCAGCCTCAACCGGGACCCCATCTGGAGGAGCCGG       GAAGAGCCCTACCATTATGGGAACAAGATGGAGCAGAACCAGACCCAGAGCCCTCTGCAGCTCCTCAG       CCAGTGCAACATCAGAACTTCCTACAGTCCAGGAGGGCAAGGGGCTGGGGCCCAGCCCGAAATGTGGG       GCAAGCACTTCAGCAACCCCAAAAGGAGCTCGTCACTGGCCATGACAGGACATGCTGGCAGCTTCATC       AAGGAATGCCGAGAAGACTATTACCCGGGGAGGCTGAGATCTCAGGAGAGCTACAGTGATATGTCTAG       TCAGAGTTTCAGTGAGACCCGAGGCAGCATCCAAGTCCCCAAATATGAGGAGGAAGAGGAAGAGGAAG       GGGGCTTGTCCACTCAGCAGTGTCGGACCCGTCATCCCATCAGTTCCCTGAAATACACAGAGGACATG       ACGCCCACAGAGCAGACCCCTCGGGGCTCCATGGAATCCCTGGCCCTGTCTAATGCAACAGGTCTCTC       TGCTGATGGTGGTGCCAAGCGCCAGGAGCACCTATCCCGATTTTCCATGCCTGACCTCAGCAAAGACT       CTGGAATGAATGTGTCTGAGAAGCTGAGCAACATGGGCACTCTTAACTCGTCCATGCAGTTCCGGAGC       GCAGAGTCAGTTCGCAGCCTGCTCTCTGCCCAGCAGTACCAGGAGATGGAGGGAAACCTCCACCAGCT       CAGCAACCCCATTGGCTACAGAGACCTGCAGTCCCACGGAAGGATGCATCAGAGCTTTGATTTTGATG       GAGGGATGGCGGGCAGCAAGCTGCCAGGGCAGGAGGGCGTGAGGATCCAGCCCATGAGTGAACGCACC       CGGAGAAGAGCTACTTCACGCGACGACAACCGCCGTTTCCGACCTCACAGGTCCAGGCGTTCCCGACG       CTCTCGCTCCGACAACGCCCTCCACCTGGCCAGCGAACGCGAGGCCATCTCCCGGTTAAAAGATAGGC       CCCCTCTGAGAGCCAGGGAGGACTATGACCAATTTATGCGCCAGCGGAGCTTCCAGGAGAGCATGGGG       CATGGGTCCCGGAGGGACCTGTACGGCCAGTGCCCTAGGACTGTGTCGGACCTGGCTTTGCAGAATGC       CTTTGGGGACCGCTGGGGACCCTACTTCGCCGAGTATGATTGGTGTTCCACCTGCTCCTCCTCTTCAG       AGTCTGACAACGAGGGCTATTTCCTAGGAGAACCCATCCCCCAGCCAGCGCGCCTGCGATACGTCACA       AGCGATGAGCTGCTGCACAAATACAGCTCCTACGGCCTCCCCAAATCTTCCACATTAGGTGGCAGAGG       ACAGTTGCACAGCAGGAAAAGACAGAAGAGCAAAAACTGTATCATTTCT TAA   TATGATTGGGATCAGG           GAATGGGAGAAGATGGGAGCTAAGAATGTAAAGTCAGAAACTTGCACTGTTTTAAATGTTAAAGCGCT           TTTGGGGGTGGCTTATGGGGGAGAAAAGGGAAAATGCTGTCAGTAGATGGAGGCAAGGTTACA                                           NOV36c, SNP13382513 of   SEQ ID NO:856   844 aa   MW at 95673.9 kD           CG56383-02, Protein Sequence   SNP Pos: 319       SNP Change: Ser to Phe                     MVTVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVNSPG           EKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSSQRKRENLGRGNVRPFPVTMTGAICEQCGGQ       INGGDIAVFASRAGHGVCWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAACDEIIFA       DECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIGIDQGQMTYD       GQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGFDSSDSAFQNARAKESRRSAKI       GKNKGKTEEPMLNQHSQLQVSSNRLSADVDPLSLQMDMLSLSSQTPSLNRDPIWRSREEPYHYGNKME       QNQTQSPLQLLSQCNIRTSYSPGGQGAGAQPEMWGKHFSNPKRSSSLAMTGHAGSFIKECREDYYPGR       LRSQESYSDMSSQSFSETRGSIQVPKYEEEEEEEGGLSTQQCRTRHPISSLKYTEDMTPTEQTPRGSM       ESLALSNATGLSADGGAKRQEHLSRFSMPDLSKDSGMNVSEKLSNMGTLNSSMQFRSAESVRSLLSAQ       QYQEMEGNLHQLSNPIGYRDLQSHGRMHQSFDFDGGMAGSKLPGQEGVRIQPMSERTRRRATSRDDNR       RFRPHRSRRSRRSRSDNALHLASEREAISRLKDRPPLRAREDYDQFMRQRSFQESMGHGSRRDLYGQC       PRTVSDLALQNAFGDRWGPYFAEYDWCSTCSSSSESDNEGYFLGEPIPQPARLRYVTSDELLHKYSSY       GLPKSSTLGGRGQLHSRKRQKSKNCIIS                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 36B.  
                   TABLE 36B                       Comparison of the NOV36 protein sequences.                                            NOV36a   MVTVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEK           NOV36b   ------------------------------------------------------------               NOV36a   VPYVNSPGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSSQRKRENLGRGNVRP       NOV36b   ------------------------------------------------------------               NOV36a   FPVTMTGAICEQCGGQINGGDIAVFASRAGHGVCWHPPCFVCTVCNELLVDLIYFYQDGK       NOV36b   ------------------------------------------------------------               NOV36a   IYCGRHHAECLKPRCAACDEIIFADECTEAEGRHWHMXHFCCFECETVLGGQRYIMKEGR       NOV36b   -----------------------------------------------------------M               NOV36a   PYCCHCFESLYAEYCDTCAQHIGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPK       NOV36b   CFTSQCRALSSSSASPMSLIFLGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPK               N0V36a   QGQIFCSRACSAGEDPNGSDSSDSAFQNARAKESRRSAKTGKNKGKTEEPMLNQHSQLQV       NOV36b   QGQIFCSRACSAGEDPNGSDSSDSAFQNARAKESRRSAKIGKNKGKTEEPMLNQHSQLQV               NOV36a   SSNRLSADVDPLSLQMDMLSLSSQTPSLNRDPIWRSREEPYHYGNKMEQNQTQSPLQLLS       NOV36b   SSNRLSADVDPLSLQMDMLSLSSQTPSLNRDPIWRSREEPYHYGNKMEQNQTQSPLQLLS               NOV36a   QCNIRTSYSPGGQGAGAQPEMWGKHFSNPKRSSSLAMTGHAGSFIKECREDYYPGRLRSQ       NOV36b   QCNIRTSYSPGGQGAGAQPEMWGKHFSNPKRSTSLAMTGHAGSFIKECREDYYPGRLRSQ               NOV36a   ESYSDMSSQSFSETRGSIQVPKYEEEEEEEGGLSTQQCRTRHPISSLKYTEDMTPTEQTP       NOV36b   ESYSDMSSQSFSETRGSIQVPKYEEEEEEEGGLSTQQCRTRHPISSLKYTEDMTPTEQTP               NOV36a   RGSMESLALSNATGLSADGGAKRQEHLSRFSMPDLSKDSGMNVSEKLSNMGTLNSSMQFR       NOV36b   RGSMESLALSNATGRFCSP-----------------------------------------               NOV36a   SAESVRSLLSAQQYQEMEGNLHQLSNPIGYRDLQSHGRMHQSFDFDGGMAGSKLPGQEGV       NOV36b   ------------------------------------------------------------               NOV36a   RIQPMSERTRRRATSRDDNRRFRPHRSRRSRRSRSDNALHLASEREAISRLKDRPPLRAR       NOV36b   ------------------------------------------------------------               NOV36a   EDYDQFMRQRSFQESMGHGSRRDLYGQCPRTVSDLALQNAFGDRWGPYFAEYDWCSTCSS       NOV36b   ------------------------------------------------------------               NOV36a   SSESDNEGYFLGEPIPQPARLRYVTSDELLHKYSSYGLPKSSTLGGRGQLHSRKRQKSKN       NOV36b   ------------------------------------------------------------               NOV36a   CIIS       NOV36b   ----               NOV36a   (SEQ ID NO: 852)       NOV36b   (SEQ ID NO: 854)                  
 
      Further analysis of the NOV36a protein yielded the following properties shown in Table 36C.  
               TABLE 36C                       Protein Sequence Properties NOV36a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 11; pos. chg 1; neg. chg 2           H-region:   length 3; peak value 0.00           PSG score:   −4.40                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −10.32           possible cleavage site: between 26 and 27                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 0                             PERIPHERAL   Likelihood = 8.54 (at 365)                         ALOM score: −1.17 (number of TMSs: 0)       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   5.58           Hyd Moment(95):   3.29   G content:   0           D/E content:   2   S/T content:   1                         Score: −7.15       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: PHRSRRS (4) at 684           bipartite: none           content of basic residues: 12.6%           NLS Score: −0.13       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: found       RIKQLLHQL at 72       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: CaaX motif in the C-terminus: CIIS                         if X is S, A, or M, it will be farnesylated           otherwise, it will be geranylgeranylated                 memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs:                         Leucine zipper pattern (PS00029): *** found ***            LQVSSNRLSADVDPLSLQMDML at 358           LIM domain signature (PS00478): *** found ***            CEQCGGQINGGDIAVFASRAGHGVCWHPPCFV            CTVCNELL at 130                 checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 94.1       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         73.9%: nuclear            8.7%: mitochondrial            8.7%: plasma membrane            8.7%: cytoplasmic                 &gt;&gt; prediction for CG56383-02 is nuc (k = 23)                  
 
      A search of the NOV36a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 36D.  
               TABLE 36D                          Geneseq Results for NOV36a                                         NOV36a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #,Date]   Residues   Region   Value               ABG07025   Novel human diagnostic protein   49 . . . 844    721/807 (89%)   0.0           #7016 -  Homo sapiens , 795 aa.   1 . . . 795   737/807 (90%)           [WO200175067-A2, 11-OCT-2001]       ABB82161   Human NOV6b protein sequence -   1 . . . 554    554/554 (100%)   0.0             Homo sapiens , 559 aa.   1 . . . 554    554/554 (100%)           [WO200270660-A2, 12-SEP-2002]       ABU11832   Human MDDT polypeptide SEQ ID   5 . . . 844   429/851 (50%)   0.0           779 -  Homo sapiens , 839 aa.   9 . . . 839   542/851 (63%)           [WO200279449-A2, 10-OCT-2002]       ABU11569   Human MDDT polypeptide SEQ ID   5 . . . 844   429/851 (50%)   0.0           516 -  Homo sapiens , 839 aa.   9 . . . 839   542/851 (63%)           [WO200279449-A2, 10-OCT-2002]       ABG08405   Novel human diagnostic protein   49 . . . 350     302/302 (100%)   0.0           #8396 -  Homo sapiens , 311 aa.   1 . . . 302    302/302 (100%)           [WO200175067-A2, 11-OCT-2001]                  
 
      In a BLAST search of public sequence databases, the NOV36a protein was found to have homology to the proteins shown in the BLASTP data in Table 36E.  
               TABLE 36E                          Public BLASTP Results for NOV36a                                         NOV36a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               AAH50793   Similar to prickle-like 1 ( Drosophila ) -   1 . . . 844   803/845 (95%)   0.0             Mus musculus  (Mouse), 879 aa   35 . . . 879    826/845 (97%)           (fragment).       AAP33399   Prickle2 -  Brachydanio rerio     5 . . . 844   569/852 (66%)   0.0           (Zebrafish) ( Danio rerio ), 840 aa.   1 . . . 840   664/852 (77%)       Q96MT3   Hypothetical protein FLJ31937 -   5 . . . 844   428/851 (50%)   0.0             Homo sapiens  (Human), 831 aa.   1 . . . 831   541/851 (63%)       Q90WV2   LIM protein prickle b -  Xenopus     5 . . . 844   413/861 (47%)   0.0             laevis  (African clawed frog), 866 aa.   35 . . . 866    538/861 (61%)       AAP33398   Prickle1 -  Brachydanio rerio     7 . . . 844   387/853 (45%)   0.0           (Zebrafish) ( Danio rerio ), 793 aa.   9 . . . 793   499/853 (58%)                  
 
      PFam analysis predicts that the NOV36a protein contains the domains shown in the Table 36F.  
               TABLE 36F                          Domain Analysis of NOV36a                                     Identities/           Pfam   NOV36a   Similarities for       Domain   Match Region   the Matched Region   Expect Value               LIM   130 . . . 192   19/66 (29%)   2.9e−11               43/66 (65%)       LIM   195 . . . 252   17/62 (27%)   3.9e−13               45/62 (73%)       LIM   255 . . . 315   16/66 (24%)   0.022               34/66 (52%)                  
 
     Example 37  
      The NOV37 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 37A.  
                   TABLE 37A                       NOV37 Sequence Analysis                                                NOV37a, CG56449-04   SEQ ID NO: 857   877 bp           DNA Sequence   ORF Start: ATG at 25   ORF Stop: TAG at 535                       CCGGAGCTGCCTGTGATGCCGTGA   ATG GCTCCTGCCTCTGCCCCGCTGGCCGCCGGGGCCCCCGCTGT           GCCGAGACCTGCCCTGCCGGCCTGTACGGCGACAACTGTCGGCATTCCTGCCTCTGCCAGAACGGAGG       GACCTGTGACCCTGTCTCAGGCCTGCGAGCACCCCTGTCCCCCTGGCTTCCACGGGGCTGGCCGCCAG       GGGTTGTGCTGGTGTCAACATGGAGCCCCCTGCGACCCCATCAGTGGCCGATGCCTCTGCCCTGCCGG       CTTCCACGGCCACTTCTGTGAGAGGGATTGCAGAAGGGGCCAGTTTGGGCCCAGCTGCACCCTGCACT       GTGACTGCGGGGGTGGGGCTGACTGCGACCCTGTCAGTGGGCAGTGTCACTGTGTGGATGGCTACATG       GGGCCCACGTGCCGGGAAGGTGGGCCCCTCCGGCTCCCCGAGAACCCGTCCTTAGCCCAGGGCTCAGC       GGGCACACTGCCCGCCTCCAGCAGACCCACATCCCGGAGCGGTGGACCAGCGAGGCAC TAG   TAGAGGC           AGTCCCGTGGAGCCCGCCTCTCCAGTCCCAGCCAGAGGGGACCCTGGCCTTTGGTGACCACTGAGAAC           GACACTTCACGGGCCCAGAGCTCCTGGTACTGCCCTTCCTTTGAGGGCCGTGGAGGGCTGTGGACAGC           CCAGCAACCTGTCGCTCTTGGAGGCTGGTGTGGCCTTGAGGAGGGAAGCCTCGCATGGCCGCTGGAAG           AGAGGCGTCTCCTGGCCTGGCTCTGCAGAACCCAGGGGCACGCTCTGGGCCTGGGCTGAGGAAGTCCC           GCTCTCCCGCGGCTCTGAGTTGGACTGAGGACAGGTGTGGGCGCCAGTGTGGGTGCAGGCG                                           NOV37a, CG56449-04                       Protein Sequence   SEQ ID NO: 858   170 aa   MW at 17123.1kD                     MAPASAPLAAGAPAVPRPALPACTATTVGIPASARTEGPVTLSQACEHPCPPGFHGAGRQGLCWCQHG           APCDPISGRCLCPAGFHGHFCERDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGG       PLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH                                     NOV37b, CG56449-09   SEQ ID NO: 859   5172 bp           DNA Sequence   ORF Start: ATG at 16   ORF Stop: TAG at 4798                       GCACCGGCGCGCACG   ATG TCGTTCCTTGAAGAGGCGAGGGCAGCGGGGCGCGCGGTGGTCCTGGCGTT           GGTGCTGCTGCTGCTCCCCGCCGTGCCCGTGGGCGCCAGCGTTCCGCCGCGGCCCCTGCTCCCGCTGC       AGCCCGGCATGCCCCACGTGTGTGCTGAGCAGGAGCTGACCCTGGTGGGCCGCCGCCAGCCGTGCGTG       CAGGCCTTAAGCCACACGGTGCCGGTGTGGAGGGCCGGCTGTGGGTGGCAGGCGTGGTGCGTGGGTCA       TGAGCGGAGAACCGTCTACTACATGGGCTACAGGCAGGTGTATACCACGGAGGCCCGGACCGTGCTCA       GGTGCTGCCGAGGGTGGACGCAGCAGCCCGACGAGGAGGGCTGCCTCTCGGCTGAATGCAGCGCCAGC       CTCTGTTTTCACGGTGGCCGTTGTGTGCCAGGCTCAGCCCAGCCGTGTCACTGTCCCCCCGGCTTCCA       GGGACCCCGCTGTCAGTATGATGTGGACGAATGCCGAACCCACAACGGTGGCTGCCAGCACCGGTGCG       TGAACACCCCAGGCTCCTACCTCTGTGAGTGCAAGCCCGGCTTCCGGCTCCACACTGACAGCAGGACC       TGCCTGGCCATTAACTCCTGCGCCCTGGGCAATGGCGGCTGCCAGCACCACTGTGTCCAGCTCACAAT       CACTCGGCATCGCTGCCAGTGCCGGCCCGGGTTCCAGCTCCAGGAGGACGGCAGGCATTGTGTCCGTA       GAAGCCCGTGTGCCAACAGGAACGGCAGCTGCATGCACAGGTGCCAGGTGGTCCCGGGGCCTCGTCAG       TGTGAGTGCCACGTGGGCTATCAGCTAGCAGCGGACGGCAAGGCCTGTGAAGATGTGGACGAATGTGC       CGCAGGGCTGGCCCAGTGTGCCCATGGCTGCCTCAACACCCAGGGGTCCTTCAAGTGCGTGTGTCACG       CGGGCTATGAGCTGGGCGCCGATGGCCGGCAGTGCTACCGTATTGAGATGGAAATCGTGAACAGCTGT       GAGGCCAACAACGGCGGCTGCTCCCATGGCTGCAGCCACACCAGTGCTGGGCCCCTGTGCACCTGTCC       CCGCGGCTACGAGCTGGACACAGATCAGAGGACCTGCATCAGATGTCGACGACTGTGCAGACAGCCCG       TGCTGCAGCAGGTGTGCACCAACAACCCTGGCGGGTACGAGTGCGGCTGCTACGCCGGCTACCGGCTC       AGTGCCGATGGCTGCGGCTGCGAGGATGTGGATGAGTGCGCCTCCAGCCGTGGCGGCTGCGAGCACCA       CTGCACCAACCTGGCCGGCTCCTTCCAGTGCTCCTGCGAGGCCGGCTACCGGCTGCACGAGGACCGTA       GGGGCTGCAGCGCCCTGGAGGAGCCGATGGTGGACCTGGACGGCGAGCTGCCTTTCGTGCGGCCCCTG       CCCCACATTGCCGTGCTCCAGGACGAGCTGCCGCAACTCTTCCAGGATGACGACGTCGGGACCGATGA       GGAAGAGGCAGAGTTGCGGGGCGAACACACGCTCACAGAGAAGTTTGTCTGCCTGGATGACTCCTTTG       GCCATGACTGCAGCTTGACCTGTGATGACTGCAGGAACGGAGGGACCTGCCTCCTGGGCCTGGATGGC       TGTGATTGCCCCGAGGGCTGGACTGGGCTCATCTGCAATGAGAGTTGTCCTCCGGACACCTTTGGGAA       GAACTGCAGCTTCTCCTGCAGCTGTCAGAATGGTGGGACCTGCGACTCTGTCACGGGGGCCTGCCGCT       GCCCCCCGGGTGTCAGTGGAACTAACTGTGAGGATGGCTGCCCCAAGGGCTACTATGGCAAGCACTGT       CGCAAGAAATGCAACTGTGCCAACCGGGGCCGGTGCCACCGCCTCTACGGGGCCTGCCTCTGCGACCC       AGGGCTCTACGGCCGCTTCTGCCACCTCGCCTGCCCGCCGTGGGCCTTTGGGCCGGGCTGCTCGGAGG       AGTGCCAGTGTGTGCAGCCCCACACGCAGTCCTGTGACAAGAGGGATGGCAGCTGCTCCTGCAAGGCT       GGCTTCCGGGGCGAGCGCTGTCAGGCAGAGTGTGAGCCGGGCTACTTTGGGCCGGGGTGCTGGCAGGC       ATGCACCTGCCCAGTGGGCGTGGCCTGTGACTCCGTGAGCGGCGAGTGTGGGAAGCGGTGTCCTGCTG       GCTTCCAGGGAGAGGACTGTGGCCAAGAGTGCCCGGTGGGGACCTTTGGCGTGAACTGCTCGAGCTCC       TGCTCCTGTGGGGGGGCCCCCTGCCACGGGGTCACGGGGCAGTGCCGGTGTCCGCCGGGGAGGACTGG       GGAAGACTGTGAGGCAGGTGAGTGTGAGGGCCTCTGGGGGCTGGGCTGCCAGGAGATCTGCCCAGCAT       GCCATAACGCTGCTCGCTGCGACCCTGAGACCGGAGCCTGCCTGTGCCTCCCTGGCTTTGTCGGCAGC       CGCTGCCAGGACTGTGAGGCAGGCTGGTATGGTCCCAGCTGCCAGACAATGTGCTCTTGTGCCAATGA       TGGGGCACTGCCACCAAGACACGGGACACTGCAGCTGTGCCCCGGGTGGACCGGCTTTAGCTGCCAGA       GAGCCTGTGATACTGGGCACTGGGGACCTGACTGCAGCCACCCCTGCAACTGCAGCGCTGGCCACGGG       AGCTGTGATGCCATCAGCGGCCTGTGTCTGTGTGAGGCTGGCTACGTGGGCCCGCGGTGCGAGCAGTC       AGAGTGTCCCCAGGGCCACTTTGGGCCCGGCTGTGAGCAGCGGTGCCAGTGTCAGCATGGAGCAGCCT       GTGACCACGTCAGCGGGGCCTGCACCTGCCCGGCCGGCTGGAGGGGCACCTTCTGCGAGCATAACTGC       CCGGCCGGCTTCTTTGGATTGGACTGTCGCAGTGCCTGCAACTGCACCGCCGGAGCTGCCTGTGATGC       CGTGAATGGCTCCTGCCTCTGCCCCGCTGGCCGCCGGGGCCCCCGCTGTGCCGAGAGTGCCTGCCCAG       CCCACACCTACGGGCACAATTGCAGCCAGGCCTGTGCCTGCTTTAACGGGGCCTCCTGTGACCCTGTC       CACGGGCAGTGCCACTGTGCCCCTGGCTGGATGGGGCCCTCCTGCCTGCAGGCCTGCCCTGCCGGCCT       GTACGGCGACAACTGTCGGCATTCCTGCCTCTGCCAGAACGGAGGGACCTGTGACCCTGTCTCAGGCC       ACTGTGCGTGCCCAGAGGGCTGGGCCGGCCTGGCCTGTGAGGTAGAGTGCCTCCCCCGGGACGTCAGA       GCTGGCTGCCGGCACAGCGGCGGTTGCCTCAACGGGGGCCTGTGTGACCCGCACACGGGCCGCTGCCT       CTGCCCAGCCGGCTGGACTGGGGACAAGTGTCAGAGCCCTGCAGCCTGTGCCAAGGAAACATTCGGGC       CTCACTGTGAGGGGCGCTGTGCCTGCCGGTGGGGAGGCCCCTGCCACCTTGCCACCGGGGCCTGCCTC       TGCCCTCCGGGGTGGCGGGGGCCTCATCTTTCTGCAGCCTGCCTGCGAAGCTGGTTTGGAGAGGCCTG       TGCCCAGCGCTGCAGCTGCCCGCCTGGCGCTGCCTGCCACCACGTCACTGGGGCCTAACGCTGTCCCC       CTGGCTTCACTGGCTCCGGCTGCGAGCAGGCCTGCCCACCCGGCAGCTTTGGGGAGGACTGTGCGCAG       ATGTGCCAGTGTCCCGGTGAGAACCCGGCCTGCCACCCTGCCACCGGGACCTGCTCATGTGCTGCTGG       CTACCACGGCCCCAGCTGCCAGCAACGATGTCCGCCCGGGCGGTATGGGCCAGGCTGTGAACAGCTGT       GTGGGTGTCTCAACGGGGGCTCCTGTGATGCGGCCACGGGGGCCTGCCGCTGCCCCACTGGGTTCCTC       GGGACGGACTGCAACCTCACCTGTCCGCAGGGCCGCTTCGGCCCCAACTGCACCCACGTGTGTGGGTG       TGGGCAGGGGGCGGCCTGCGACCCTGTGACCGGCACCTGCCTCTGCCCCCCGGGGAGAGCCGGCGTCC       GCTGTGAGCGAGGCTGCCCCCAGAACCGGTTTGGCGTGGGCTGCGAGCACACCTGCTCCTGCAGAAAT       GGGGGCCTGTGCCACGCCAGCGGGGCCTGTGCCACGCCAGCAAGCGGCAGCTGCTCCTGTGGCCTGGG       CTGGACGGGGCGGCACTGCGAGCTGGCCTGTCCCCCTGGGCGCTACGGAGCCGCCTGCCATCTGGAGT       GCTCCTGCCACAACAACAGCACGTGTGAGCCTGCCACGGGCACCTGCCGCTGCGGCCCCGGCTTCTAT       GGCCAGGCCTGCGAGCACCCCTGTCCCCCTGGCTTCCACGGGGCTGGCTGCCAAAGGTTGTGCTGGTG       TCAACATGGAGCCCCCTGCGACCCCATCAGTGGCCGATGCCTCTGCCCTGCCGAATTCCACGAACACT       TCTGTGAGAGGGGGTGTGAGCCAGGTTCATTTGGAGAGGGCTGCCACCAGCGCTGTGACTGTGACGGG       GGGGCACCCTGTGACCCTGTCACCGGTCTCTGCCTTTGCCCACCAGGGCGCTCAGGAGCCACCTGTAA       CCTGGATTGCAGGGGGGGCCAGTTTGGGCCCAGCTGCACCCTGCACTGTGACTGCGGGGGTGGGGCTG       ACTGCGACCCTGTCAGTGGGCAGTGTCACTGTGTGGATGGCTACATGGGGCCCACGGGCCGGGGGGGT       GGGCCCCTCCGGCTCCCCGAGAACCCGTCCTTAGCCCAGGGCTCAGCGGGCACACTGCCCGCCTCCAG       CAGACCCACATCCCGGAGCGGTGGACCAGCGAGGCAC TAG   TAGAGGCAGTCCCGTGGAGCCCGCCTCT           CCAGTCCCAGCCAGAGGGGACTCTGGCCTTTGGTGACCACTGAGAAGGACACTTCACGGGCCCAGAGC           TCCTGGTACTGCCCTTCCTTTGAGGGCCGTGGAGGGCTGTGGACAGCCCAGCAACCTGTCGCTCTTGG           AGGCTGGTGTGGCCTTGAGGAGGGAAGCCTCGCATGGCCGCTGGAAGAGAGGCGCCTCCTGGCCTGGC           TCTGCAGAACCCAGGGGCACGCTCTGGGCCTGGGCTGAGGAAGTCCCGCTCTCCCCGCGGCTCTGAGT           TGGACTGAGGACAGGTGTGGGCGCCAGTGTGGGTGCAGTCACAGTGCAGGGTGCAGTCACAGTGCAGC           GTGC                                           NOV37b, CG56449-09                       Protein Sequence   SEQ ID NO: 860   1594 aa   MW at 166431.4kD                     MSFLEEARAAGRAVVLALVLLLLPAVPVGASVPPRPLLPLQPGMPHVCAEQELTLVGRRQPCVQALSH           TVPVWPAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWTQQPDEEGCLSAECSASLCFHG       GRCVPGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAIN       SCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHV       GYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNG       GCSHGCSHTSAGPLCTCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGC       GCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHIAV       LQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPE       GWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCN       CANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGE       RCQAECEPGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGG       APCHGVTGQCRCPPGRTGEDCEAGECEGLWGLGCQEICPACHNAARCDPETGACLCLPGFVGSRCQDC       EAGWYGPSCQTMCSCANDGHCHQDTGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAI       SGLCLCEAGYVGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFF       GLDCRSACNCTAGAACDAVTGSCLCPAGRRGPRCAESACPAHTYGHNCSQACACFNGASCDPVHGQCH       CAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEVECLPRDVRAGCRH       SGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPHCEGRCACRWGGPCHLATGACLCPPGW       RGPHLSAACLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCP       GENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCN       LTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCH       ASGACATPASGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACE       HPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCD       PVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGGPLRL       PENPSLAQGSAGTLPASSRPTSRSGGPARH                                     NOV37c, 191887507   SEQ ID NO: 861   522 bp           DNA Sequence   ORF Start: at 2   ORF Stop: at 521                       G GATCCGTGCCTCGCTGGTCCACCGCTCATGGCTCCTGCCTCTGCCCCGCTGGCCGCCGGGGCCCCCG           CTGTGCCGAGACCTGCCCTGCCGGCCTGTACGGCGACAACTGTCGGCATTCCTGCCTCTGCCAGAACG       GAGGGACCTGTGACCCTGTCTCAGGCCTGCGAGCACCCCTGTCCCCCTGGCTTCCACGGGGCTGGCTG       CCAGGGGTTGTGCTGGTGTCAACATGGAGCCCCCTGCGACCCCATCAGTGGCCGATGCCTCTGCCCTG       CCGGCTTCCACGGCCACTTCTGTGAGAGGGATTGCAGAAGGGGCCAGTTTGGGCCCAGCTGCACCCTG       CACTGTGACTGCGGGGGTGGGGCTGACTGCGACCCTGTCAGTGGGCAGTGTCACTGTGTGGATGGCTA       CATGGGGCCCACGTGCCGGGAAGGTGGGCCCCTCCGGCTCCCCGAGAACCCGTCCTTAGCCCAGGGCT       CAGCGGGCACACTGCCCGCCTCCAGCAGACCCACATCCCGCTCGAG                                         NOV37c, 191887507                       Protein Sequence SEQ ID NO: 862   173 aa   MW at 17358.4kD                     DPCLAGPPLMAPASAPLAAGAPAVPRPALPACTATTVGIPASARTEGPVTLSQACEHPCPPGFHGAGC           QGLCWCQHGAPCDPISGRCLCPAGFHGHFCERDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGY       MGPTCREGGPLRLPENPSLAQGSAGTLPASSRPTSRS                                     NOV37d, 316351371   SEQ ID NO: 863   4255 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCACCATGTCGTTCCTTGAAGAGGCGAGGGCAGCGGGGCGCGCGGTGGTCCTGGCGTTGG           TGCTGCTGCTGCTCCCCGCCGTGCCCGTGGGCGCCAGCGTTCCGCCGCGGCCCCTGCTCCCGCTGCAG       CCCGGCATGCCCCACGTGTGTGCTGAGCAGGAGCTGACCCTGGTGGGCCGCCGCCAGCCGTGCGTGCA       GGCCTTAAGCCACACGGTGCCGGTGTGGAAGGCCGGCTGTGGGTGGCAGGCGTGGTGCGTGGGTCATG       AGCGGAGAACCGTCTACTACATGGGCTACAGGCAGGTGTATACCACGGAGGCCCGGACCGTGCTCAGG       TGCTGCCGAGGGTGGACGCAGCAGCCCGACGAGGAGGGCTGCCTCTCGGCTGAATGCAGCGCCGGCCT       CTGTTTTCACGGTGGCCGTTGTGTGCCAGGCTCAGCCCAGCCGTGTCACTGTCCCCCCGGCTTCCAGG       GACCCCGCTGTCAGTATGATGTGGACGAATGCCGAACCCACAACGGTGGCTGCCAGCACCGGTGCGTG       AACACCCCAGGCTCCTACCTCTGTGAGTGCAAGCCCGGCTTCCGGCTCCACACTGACAGCAGGACCTG       CCTGGCCATTAACTCCTGCGCCCTGGGCAATGGCGGCTGCCAGCACCACTGTGTCCAGCTCACAATCA       CTCGGCATCGCTGCCAGTGCCGGCCCGGGTTCCAGCTCCAGGAGGACGGCAGGCATTGTGTCCGTAGA       AGCCCGTGTGCCAACAGGAACGGCAGCTGCATGCACAGGTGCCAGGTGGTCCGGGGCCTCGCCCGCTG       TGAGTGCCACGTGGGCTATCAGCTAGCAGCGGACGGCAAGGCCTGTGAAGATGTGGACGAATGTGCCG       CAGGGCTGGCCCAGTGTGCCCATGGCTGCCTCAACACCCAGGGGTCCTTCAAGTGCGTGTGTCACGCG       GGCTATGAGCTGGGCGCCGATGGCCGGCAGTGCTACCGGATTGAGATGGAAATCGTGAACAGCTGTGA       GGCCAACAACGGCGGCTGCTCCCATGGCTGCAGCCACACCAGTGCTGGGCCCCTGTGCACCTGTCCCC       GCGGCTACGAGCTGGACACAGATCAGAGGACCTGCATCGATGTCGGCGACTGTGCAGACAGCCCGTGC       TGCCAGCAGGTGTGCACCAACAACCCTGGCGGGTACGAGTGCGGCTGCTACGCCGGCTACCGGCTCAG       TGCCGATGGCTGCGGCTGTGAGGATGTGGATGAGTGCGCCTCCAGCCGTGGCGGCTGCGAGCACCACT       GCACCAACCTGGCCGGCTCCTTCCAGTGCTCCTGCGAGGCCGGCTACCGGCTGCACGAGGACCGTAGG       GGCTGCAGCCCCCTGGAGGAGCCGATGGTGGACCTGGACGGCGAGCTGCCTTTCGTGCGGCCCCTGCC       CCACATTGCCGTGCTCCAGGACGAGCTGCCGCAACTCTTCCAGGATGACGACGTCGGGGCCGATGAGG       AAGAGGCAGAGTTGCGGGGCGAACACACGCTCACAGAGAAGTTTGTCTGCCTGGATGACTCCTTTGGC       CATGACTGCAGCTTGACCTGTGATGACTGCAGGAACGGAGGGACCTGTCTCCTGGGCCTGGATGGCTG       TGATTGCCCCGAGGGCTGGACTGGGCTCATCTGCAATGAGACTTGTCCTCCGGACACCTTTGGGAAGA       ACTGCAGCTTCTCCTGCAGCTGTCAGAATGGTGGGACCTGCGACTCTGTCACGGGGGCCTGCCGCTGC       CCCCCGGGTGTCAGTGGAACTAACTGTGAGGATGGCTGCCCCAAGGGCTACTATGGCAAGCACTGTCG       CAAGAAATGCAACTGTGCCAACCGGGGCCGGTGCCACCGCCTCTACGGGGCCTGCCTCTGCGACCCAG       GGCTCTACGGCCGCTTCTGCCACCTCACCTGCCCGCCGTGGGCCTTTGGGCCGGGCTGCTCGGAGGAG       TGCCAGTGTGTGCAGCCCCACACGCAGTCCTGTGACAAGAGGGATGGCAGCTGCTCCTGCAAGGCTGG       CTTCCGGGGCGAGCGCTGTCAGGCAGAGTGTGAGCCGGGCTACTTTGGGCCGGGGTGCTGGCAGGCAT       GCACCTGCCCAGTGGGCGTGGCCTGTGACTCCGTGAGCGGCGAGTGTGGGAAGCGGTGTCCTGCTGGC       TTCCAGGGAGAGGACTGTGGCCAAGAGTGCCCGGTGGGGACGTTTGGCGTGAACTGCTCGAGCTCCTG       CTCCTGTGGGGGGGCCCCCTGCCACGGGGTCACGGGGCAGTGCCGGTGTCCACCGGGGAGGACTGGGG       AAGACTGTGAGGCAGATTGTCCCGAGGGCCGCTGGGGGCTGGGCTGCCAGGAGATCTGCCCAGCATGC       CAGCACGCTGCCCGCTGCGACCCTGAGACCGGAGCCTGCCTGTGCCTCCCTGACTTCGTCGGCAGCCG       CTGCCAGGACGTGTGCCCAGCAGGCTGGTATGGTCCCAGCTGCCAGACAAGGTGCTCTTGTGCCAATG       ATGGGCACTGCCACCCAGCCACCGGACACTGCAGCTGTGCCCCCGGGTGGACCGGCTTTAGCTGCCAG       AGTGTCCCCAGGGCCACTTTGGGCCCGGCTGTGAGCAGCTGTGCCAGTGTCAGCATGGAGCAGCCTGT       GACCACGTCAGCGGGGCCTGCACCTGCCCGGCCGGCTGGAGGGGCACCTTCTGCGAGCATGCCTGCCC       GGCCGGCTTCTTTGGATTGGACTGTCGCAGTGCCTGCAACTGCACCGCCGGAGCTGCCTGTGATGCCG       TGAATGGCTCCTGCCTCTGCCCCGCTGGCCGCCGGGGCCCCCGCTGTGCCGAGAAGTGCCTCCCCCGG       CCGCTGCCTCTGCCCAGCCGGCTGGACTGGGGACAAGTGTCAGAGCCCCTGCCTGCGGGGCTGGTTTG       GAGAGGCCTGTGCCCAGCGCTGCAGCTGCCCGCCTGGCGCTGCCTGCCACCACGTCACTGGGGCCTGC       CGCTGTCCCCCTGGCTTCACTGGCTCCGGCTGCGAGCAGGGATGTCCGCCCGGGCGGTATGGGCCAGG       CTGTGAACAGCTGTGTGGGTGTCTCAACGGGGGCTCCTGTGATGCGGCCACGGGGGCCTGCCGCTGCC       CCACTGGGTTCCTCGGGACGGACTGCAACCTCACCTGTCCGCAGGGCCGCTTCGGCCCCAACTGCACC       GAGAGCCGGCGTCCGCTGTGAGCGAGGCTGCCCCCAGAACCGGTTTGGCGTGGGCTGCGAGCACACCT       GCTCCTGCAGAAATGGGGGCCTGTGCCACGCCAGCAACGGCAGCTGCTCCTGTGGCCTGGGCTGGACG       GGGCGGCACTGCGAGCTGGCCTGTCCCCCTGGGCGCTACGGAGCCGCCTGCCATCTGGAGTGCTCCTG       CCACAACAACAGCACGTGTGAGCCTGCCACGGGCACCTGCCGCTGCGGCCCCGGCTTCTATGGCCAGG       CCTGCGAGCACCCCTGTCCCCCTGGCTTCCACGGGGCTGGCTGCCAGGGGTTGTGCTGGTGTCAACAT       GGAGCCCCCTGCGACCCCATCAGTGGCCGATGCCTCTGCCCTGCCGGCTTCCACGGCCACTTCTGTGA       GAGGGGGTGTGAGCCAGGTTCATTTGGAGAGGGCTGCCACCAGCGCTGTGACTGTGACGGGGGGGCAC       CCTGTGACCCTGTCACCGGTCTCTGCCTTTGCCCACCAGGGCGCTCAGGAGCCACCTGTAACCTGGAT       TGCAGAAGGGGCCAGTTTGGGCCCAGCTGCACCCTGCACTGTGACTGCGGGGGTGGGGCTGACTGCGA       CCCTGTCAGTGGGCAGTGTCACTGTGTGGATGGCTACATGGGGCCCACGTGCCGGGAAGGTGGGCCCC       TCCGGCTCCCCGAGAACCCGTCCTTAGCCCAGGGCTCAGCGGGCACACTGCCCGCCTCCAGCAGACCC                                         NOV37d, 316351371                       Protein Sequence   SEQ ID NO: 864   1418 aa   MW at 148398.2kD                     TGSTMSFLEEARAAGRAVVLALVLLLLPAVPVGASVPPRPLLPLQPGMPHVCAEQELTLVGRRQPCVQ           ALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWTQQPDEEGCLSAECSAGL       CFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTC       LAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARC       ECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCE       ANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVGDCADSPCCQQVCTNNPGGYECGCYAGYRLS       ADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLP       HIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGC       DCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCR       KKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAG       FRGERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSC       SCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPDFVGSR       CQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHG       SCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEHACP       AGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAEKCLPRDVRAGCRHSGGCLNGGLCDPHTG       RCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQGCPPGRYGPG       CEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPG       RAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCETACPPGRYGAACHLECSC       HNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCE       RGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATCNLDCRPGQFGPSCTLHCDCGGGADCD       PVSGQCHCVDGYMGPTCREGGPLRLPENPSLAQGSAGTLPASSRPTSRSGGPARHGTG                                     NOV37e, 316935396   SEQ ID NO: 865   5000 bp           DNA Sequence   ORF Start: at 28   ORF Stop: TGA at 4987                       TGCTGTTACAGGTGGAGGGCAGTGTAG TCTGAGCAGTACTCGTTGCTGCCGCGCGCGCCACCAGACAT           AATAGCTGACAGACTAACAGACTGTTCCTTTCCATGGGTCTTTTCTGCAGTCACCGTCCTTGACACGA       AGCTTTCTAGAAGATCTTCGCGAGGATCCACCATGTCGTTCCTTGAAGAGGCGAGGGCAGCGGGGCGC       GCGGTGGTCCTGGCGTTGGTGCTGCTGCTGCTCCCCGCCGTGCCCGTGGGCGCCAGCGTTCCGCCGCG       GCCCCTGCTCCCGCTGCAGCCCGGCATGCCCCACGTGTGTGCTGAGCAGGAGCTGACCCTGGTGGGCC       GCCGCCAGCCGTGCGTGCAGGCCTTAAGCCACACGGTGCCGGTGTGGAAGGCCGGCTGTGGGTGGCAG       GCGTGGTGCGTGGGTCATGAGCGGAGGACCGTCTACTACATGGGCTACAGGCAGGTGTATACCACGGA       GGCCCGGACCGTGCTCAGGTGCTGCCGAGGGTGGATGCAGCAGCCCGACGAGGAGGGCTGCCTCTCGG       ATGTGGGTGAGTGTGCCAACGCCAACGGGGGCTGTGCGGGTCGGTGCCGGGACACCGTGGGGGGCTTC       TACTGCCGCTGGCCCCCCCCCAGCCACCAGCTGCAGGGTGATGGCGAGACTTGCCAAGATGTGGACGA       ATGCCGAACCCACAACGGTGGCTGCCAGCACCGGTGCGTGAACACCCCAGGCTCCTACCTCTGTGAGT       GCAAGCCCGGCTTCCGGCTCCACACTGACAGCAGGACCTGCGCCATTAACTCCTGCGCCCTGGGCAAT       GGCGGCTGCCAGCACCACTGTGTCCAGCTCACAATCACTCGGCATCGCTGCCAGTGCCGGCCCGGGTT       CCAGCTCCAGGAGGACGGCAGGCATTGTGTCCGTAGAAGCCCGTGTGCCAACAGGAACGGCAGCTGCA       TGCACAGGTGCCAGGTGGTCCGGGGCCTCGCCCGCTGTGAGTGCCACGTGGGCTATCAGCTAGCAGCG       GACGGCAAGGCCTGTGAAGATGTGGACGAATGTGCCGCAGGGCTGGCCCAGTGTGCCCATGGCTGCCT       CAACACCCAGGGGTCCTTCAAGTGCGTGTGTCACGCGGGCTATGAGCTGGGCGCCGATGGCCGGCAGT       GCTACCGTATTGAGATGGAAATCGTGAACAGCTGTGAGGCCAACAACGGCGGCTGCTCCCATGGCTGC       AGCCACACCAGTGCTGGGCCCCTGTGCACCTGTCCCCGCGGCTACGAGCTGGACACAGATCAGAGGAC       CTGCATCAGATGTCGACGACTGTGCAGACAGCCCGTGCTGCAGCAGGTGTGCACCAACAACCCTGGCG       GGTACGAGTGCGGCTGCTACGCCGGCTACCGGCTCAGTGCCGATGGCTGCGGCTGCGAGGATGTGGAT       GAGTGCGCCTCCAGCCGTGGCGGCTGCGAGCACCACTGCACCAACCTGGCCGGCTCCTTCCAGTGCTC       CTGCGAGGCCGGCTACCGGCTGCACGAGGACCGTAGGGGCTGCAGCGCCCTGGAGGAGCCGATGGTGG       ACCTGGACGGCGAGCTGCCTTTCGTGCGGCCCCTGCCCCACATTGCCGTGCTCCAGGACGAGCTGCCG       CAACTCTTCCAGGATGACGACGTCGGGGCCGATGAGGAAGAGGCAGAGTTGCGGGGCGAACACACGCT       CACAGAGAAGTTTGTCTGCCTGGATGACTCCTTTGGCCATGACTGCAGCTTGACCTGTGATGACTGCA       GGAACGGAGGGACCTGCCTCCTGGGCCTGGATGGCTGTGATTGCCCCGAGGGCTGGACTGGGCTCATC       TGCAATGAGAGTTGTCCTCCGGACACCTTTGGGAAGAACTGCAGCTTCTCCTGCAGCTGTCAGAATGG       TGGGACCTGCGACTCTGTCACGGGGGCCTGCCGCTGCCCCCCGGGTGTCAGTGGAACTAACTGTGAGG       ATGGCTGCCCCAAGGGCTACTATGGCAAGCACTGTCGCAAGAAATGCAACTGTGCCAACCGGGGCCGG       TGCCACCGCCTCTACGGGGCCTGCCTCTGCGACCCAGGGCTCTACGGCCGCTTCTGCCACCTCGCCTG       CCCGCCGTGGGCCTTTGGGCCGGGCTGCTCGGAGGAGTGCCAGTGTGTGCAGCCCCACACGCAGTCCT       GTGACAAGAGGGATGGCAGCTGCTCCTGCAAGGCTGGCTTCCGGGGCGAGCGCTGTCAGGCAGAGTGT       GAGCCGGGCTACTTTGGGCCGGGGTGCTGGCAGGCATGCACCTGCCCAGTGGGCGTGGCCTGTGACTC       CGTGAGCGGCGAGTGTGGGAAGCGGTGTCCTGCTGGCTTCCAGGGAGAGGACTGTGGCCAAGAGTGCC       CGGTGGGGACCTTTGGCGTGAACTGCTCGAGCTCCTGCTCCTGTGGGGGGGCCCCCTGCCACGGGGTC       ACGGGGCAGTGCCGGTGTCCGCCGGGGAGGACTGGGGAAGACTGTGAGGCAGGTGAGTGTGAGGGCCT       CTGGGGGCTGGGCTGCCAGGAGATCTGCCCAGCATGCCATAACGCTGCTCGCTGCGACCCTGAGACCG       GAGCCTGCCTGTGCCTCCCTGGCTTTGTCGGCAGCCGCTGCCAGGACTGTGAGGCAGGCTGGTATGGT       CCCAGCTGCCAGACAATGTGCTCTTGTGCCAATGATGGGCACTGCCACCAAGACACGGGACACTGCAG       CTGTGCCCCCGGGTGGACCGGCTTTAGCTGCCAGAGAGCCTGTGATACTGGGCACTGGGGACCTGACT       GCAGCCACCCCTGCAACTGCAGCGCTGGCCACGGGAGCTGTGATGCCATCAGCGGCCTGTGTCTGTGT       GAGGCTGGCTACGTGGGCCCGCGGTGCGAGCAGTCAGAGTGTCCCCAGGGCCACTTTGGGCCCGGCTG       TGAGCAGCGGTGCCAGTGTCAGCATGGAGCAGCCTGTGACCACGTCAGCGGGGCCTGCACCTGCCCGG       CCGGCTGGAGGGGCACCTTCTGCGAGCATGCCTGCCCGGCCGGCTTCTTTGGATTGGACTGTCGCAGT       GCCTGCAACTGCACCGCCGGAGCTGCCTGTGATGCCGTGAATGGCTCCTGCCTCTGCCCCGCTGGCCG       CCGGGGCCCCCGCTGTGCCGAGAGTGCCTGCCCAGCCCACACCTACGGGCACAATTGCAGCCAGGCCT       GTGCCTGCTTTAACGGGGCCTCCTGTGACCCTGTCCACGGGCAGTGCCACTGTGCCCCTGGCTGGATG       GGGCCCTCCTGCCTGCAGGCCTGCCCTGCCGGCCTGTACGGCGACAACTGTCGGCATTCCTGCCTCTG       CCAGAACGGAGGGACCTGTGACCCTGTCTCAGGCCACTGTGCGTGCCCAGAGGGCTGGGCCGGCCTGG       CCTGTGAGGTAGAGTGCCTCCCCCGGGACGTCAGAGCTGGCTGCCGGCACAGCGGCGGTTGCCTCAAC       GGGGGCCTGTGTGACCCGCACACGGGCCGCTGCCTCTGCCCAGCCGGCTGGACTGGGGACAAGTGTCA       GAGCCCTGCAGCCTGTGCCAAGGGCACATTCGGGCCTCACTGTGAGGGGCGCTGTGCCTGCCGGTGGG       GAGGCCCCTGCCACCTTGCCACCGGGGCCTGCCTCTGCCCTCCGGGGTGGCGGGGGCCTCATCTTTCT       GCAGCCTGCCTGCGGGGCTGGTTTGGAGAGGCCTGTGCCCAGCGCTGCAGCTGCCCGCCTGGCGCTGC       CTGCCACCACGTCACTGGGGCCTGCCGCTGTCCCCCTGGCTTCACTGGCTCCGGCTGCGAGCAGGCCT       GCCCACCCGGCAGCTTTGGGGAGGACTGTGCGCAGATGTGCCAGTGTCCCGGTGAGAACCCGGCCTGC       CACCCTGCCACCGGGACCTGCTCATGTGCTGCTGGCTACCACGGCCCCAGCTGCCAGCAACGATGTCC       GCCCGGGCGGTATGGGCCAGGCTGTGAACAGCTGTGTGGGTGTCTCAACGGGGGCTCCTGTGATGCGG       CCACGGGGGCCTGCCGCTGCCCCACTGGGTTCCTCGGGACGGACTGCAACCTCACCTGTCCGCAGGGC       CGCTTCGGCCCCAACTGCACCCACGTGTGTGGGTGTGGGCAGGGGGCGGCCTGCGACCCTGTGACCGG       CACCTGCCTCTGCCCCCCGGGGAGAGCCGGCGTCCGCTGTGAGCGAGGCTGCCCCCAGAACCGGTTTG       GCGTGGGCTGCGAGCACACCTGCTCCTGCAGAAATGGGGGCCTGTGCCACGCCAGCAACGGCAGCTGC       TCCTGTGGCCTGGGCTGGACGGGGCGGCACTGCGAGCTGGCCTGTCCCCCTGGGCGCTACGGAGCCGC       CTGCCATCTGGAGTGCTCCTGCCACAACAACAGCACGTGTGAGCCTGCCACGGGCACCTGCCGCTGCG       GCCCCGGCTTCTATGGCCAGGCCTGCGAGCACCCCTGTCCCCCTGGCTTCCACGGGGCTGGCTGCCAG       GGGTTGTGCTGGTGTCAACATGGAGCCCCCTGCGACCCCATCAGTGGCCGATGCCTCTGCCCTGCCGG       CTTCCACGGCCACTTCTGTGAGAGGGGGTGTGAGCCAGGTTCATTTGGAGAGGGCTGCCACCAGCGCT       GTGACTGTGACGGGGGGGCACCCTGTGACCCTGTCACCGGTCTCTGCCTTTGCCCACCAGGGCGCTCA       GGAGCCACCTGTAACCTGGATTGCAGAAGGGGCCAGTTTGGGCCCAGCTGCACCCTGCACTGTGACTG       CGGGGGTGGGGCTGACTGCGACCCTGTCAGTGGGCAGTGTCACTGTGTGGATGGCTACATGGGGCCCA       CGTGCCGGGAAGCGGGCACACTGCCCGCCTCCAGCAGACCCACATCCCGGAGCGGTGGACCAGCGAGG       CACGTATTCCCCGGGCTCGAGGGTAAGCCTATCCCTAACCCTCTCCTCGGTCTCGATTCTACGCGTAC       CGGTCATCACCACCATCACCAT TGA   GTTTAATTCAT                                           NOV37e, 316935396                       Protein Sequence   SEQ ID NO: 866   1653 aa   MW at 173369.0kD                     SEQYSLLPRAPPDIIADRLTDCSFPWVFSAVTVLDTKLSRRSSRGSTMSFLEEARAAGRAVVLALVLL           LLPAVPVGASVPPRPLLPLQPGMPHVCAEQELTLVGRRQPCVQALSHTTPVWKAGCGWQAWCVGHERR       TVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEGCLSDVGECANANGGCAGRCRDTVGGFYCRWPPPSH       QLQGDGETCQDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCAINSCALGNGGCQHHCVQ       LTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVD       ECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC       TCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGC       EHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVG       ADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNESCPPDT       FGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACL       CDPGLYGRFCHTACPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECEPGYFGPGC       WQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPG       RTGEDCEAGECEGLWGLGCQEICPACHNAARCDPETGACLCLPGFVGSRCQDCEAGWYGPSCQTMCSC       ANDGHCHQDTGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRC       EQSECPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAA       CDAVNGSCLCPAGRRGPRCAESACPAETYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACP       AGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEVECLPRDVRAGCRhSGGCLNGGLCDPHTG       RCLCPAGWTGDKCQSPAACAKGTFGPHCEGRCACRWGGPCHLATGACLCPPGWRGPHLSAACLRGWFG       EACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSC       AAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHV       CGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGR       HCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGA       PCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATCNLDCR       RGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREAGTLPASSRPTSRSGGPARHVFPGLEGK       PIPNPLLGLDSTRTGHHHHHH                                     NOV37f, 317004318   SEQ ID NO: 867   5005 bp           DNA Sequence   ORF Start: at 126   ORF Stop: TGA at 4986                       AACGGGTGGAGGGCAGTGTAGTCTGAGCAGTACTCGTTGCTGCCGCGCGCGCCACCAGACATAATAGC               TGACAGACTAACAGACTGTTCCTTTCCATGGGTCTTTTCTGCAGTCACCGTCCTTGA CACGAAGCTCT       AGCCACCATGGAGACAGACACACTCCTGCTATGGGTACTGCTGCTCTGGGTTCCAGGTTCCACTGGTG       ACGCGGCCCAGCCGGCCAGGCGCGCGCGCCGTACGAAGCTTTCGCGAGGATCCAGCGTTCCGCCGCGG       CCCCTGCTCCCGCTGCAGCCCGGCATGCCCCACGTGTGTGCTGAGCAGGAGCTGACCCTGGTGGGCCG       CCGCCAGCCGTGCGTGCAGGCCTTAAGCCACACGGTGCCGGTGTGGAAGGCCGGCTGTGGGTGGCAGG       CGTGGTGCGTGGGTCATGAGCGGAGGACCGTCTACTACATGGGCTACAGGCAGGTGTATACCACGGAG       GCCCGGACCGTGCTCAGGTGCTGCCGAGGGTGGATGCAGCAGCCCGACGAGGAGGGCTGCCTCTCGGA       TGTGGGTGAGTGTGCCAACGCCAACGGGGGCTGTGCGGGTCGGTGCCGGGACACCGTGGGGGGCTTCT       ACTGCCGCTGGCCCCCCCCCAGCCACCAGCTGCAGGGTGATGGCGAGACTTGCCAAGATGTGGACGAA       TGCCGAACCCACAACGGTGGCTGCCAGCACCGGTGCGTGAACACCCCAGGCTCCTACCTCTGTGAGTG       CAAGCCCGGCTTCCGGCTCCACACTGACAGCAGGACCTGCGCCATTAACTCCTGCGCCCTGGGCAATG       GCGGCTGCCAGCACCACTGTGTCCAGCTCACAATCACTCGGCATCGCTGCCAGTGCCGGCCCGGGTTC       CAGCTCCAGGAGGACGGCAGGCATTGTGTCCGTAGAAGCCCGTGTGCCAACAGGAACGGCAGCTGCAT       GCACAGGTGCCAGGTGGTCCGGGGCCTCGCCCGCTGTGAGTGCCACGTGGGCTATCAGCTAGCAGCGG       ACGaCAAGGCCTGTGAAGATGTGGACGAATGTGCCGCAGGGCTGGCCCAGTGTGCCCATGGCTGCCTC       AACACCCAGGGGTCCTTCAAGTGCGTGTGTCACGCGGGCTATGAGCTGGGCGCCGATGGCCGGCAGTG       CTACCGTATTGAGATGGAAATCGTGAACAGCTGTGAGGCCAACAACGGCGGCTGCTCCCATGGCTGCA       GCCACACCAGTGCTGGGCCCCTGTGCACCTGTCCCCGCGGCTACGAGCTGGACACAGATCAGAGGACC       TGCATCAGATGTCGACGACTGTGCAGACAGCCCGTGCTGCAGCAGGTGTGCACCAACAACCCTGGCGG       GTACGAGTGCGGCTGCTACGCCGGCTACCGGCTCAGTGCCGATGGCTGCGGCTGCGAGGATGTGGATG       AGTGCGCCTCCAGCCGTGGCGGCTGCGAGCACCACTGCACCAACCTGGCCGGCTCCTTCCAGTGCTCC       TGCGAGGCCGGCTACCGGCTGCACGAGGACCGTAGGGGCTGCAGCGCCCTGGAGGAGCCGATGGTGGA       CCTGGACGGCGAGCTGCCTTTCGTGCGGCCCCTGCCCCACATTGCCGTGCTCCAGGACGAGCTGCCGC       AACTCTTCCAGGATGACGACGTCGGGGCCGATGAGGAAGAGGCAGAGTTGCGGGGCGAACACACGCTC       ACAGAGAAGTTTGTCTGCCTGGATGACTCCTTTGGCCATGACTGCAGCTTGACCTGTGATGACTGCAG       GAACGGAGGGACCTGCCTCCTGGGCCTGGATGGCTGTGATTGCCCCGAGGGCTGGACTGGGCTCATCT       GCAATGAGAGTTGTCCTCCGGACACCTTTGGGAAGAACTGCAGCTTCTCCTGCAGCTGTCAGAATGGT       GGGACCTGCGACTCTGTCACGGGGGCCTGCCGCTGCCCCCCGGGTGTCAGTGGAACTAACTGTGAGGA       TGGCTGCCCCAAGGGCTACTATGGCAAGCACTGTCGCAAGAAATGCAACTGTGCCAACCGGGGCCGGT       GCCACCGCCTCTACGGGGCCTGCCTCTGCGACCCAGGGCTCTACGGCCGCTTCTGCCACCTCGCCTGC       CCGCCGTGGGCCTTTGGGCCGGGCTGCTCGGAGGAGTGCCAGTGTGTGCAGCCCCACACGCAGTCCTG       TGACAAGAGGGATGGCAGCTGCTCCTGCAAGGCTGGCTTCCGGGGCGAGCGCTGTCAGGCAGAGTGTG       AGCCGGGCTACTTTGGGCCGGGGTGCTGGCAGGCATGCACCTGCCCAGTGGGCGTGGCCTGTGACTCC       GTGAGCGGCGAGTGTGGGAAGCGGTGTCCTGCTGGCTTCCAGGGAGAGGACTGTGGCCAAGAGTGCCC       GGTGGGGACCTTTGGCGTGAACTGCTCGAGCTCCTGCTCCTGTGGGGGGGCCCCCTGCCACGGGGTCA       CGGGGCAGTGCCGGTGTCCGCCGGGGAGGACTGGGGAAGACTGTGAGGCAGGTGAGTGTGAGGGCCTC       TGGGGGCTGGGCTGCCAGGAGATCTGCCCAGCATGCCATAACGCTGCTCGCTGCGACCCTGAGACCGG       AGCCTGCCTGTGCCTCCCTGGCTTTGTCGGCAGCCGCTGCCAGGACTGTGAGGCAGGCTGGTATGGTC       CCAGCTGCCAGACAATGTGCTCTTGTGCCAATGATGGGCACTGCCACCAAGACACGGGACACTGCAGC       TGTGCCCCCGGGTGGACCGGCTTTAGCTGCCAGAGAGCCTGTGATACTGGGCACTGGGGACCTGACTG       AGGCTGGCTACGTGGGCCCGCGGTGCGAGCAGTCAGAGTGTCCCCAGGGCCACTTTGGGCCCGGCTGT       GAGCAGCGGTGCCAGTGTCAGCATGGAGCAGCCTGTGACCACGTCAGCGGGGCCTGCACCTGCCCGGC       CGGCTGGAGGGGCACCTTCTGCGAGCATGCCTGCCCGGCCGGCTTCTTTGGATTGGACTGTCGCAGTG       CCTGCAACTGCACCGCCGGAGCTGCCTGTGATGCCGTGAATGGCTCCTGCCTCTGCCCCGCTGGCCGC       CGGGGCCCCCGCTGTGCCGAGAGTGCCTGCCCAGCCCACACCTACGGGCACAATTGCAGCCAGGCCTG       TGCCTGCTTTAACGGGGCCTCCTGTGACCCTGTCCACGGGCAGTGCCACTGTGCCCCTGGCTGGATGG       GGCCCTCCTGCCTGCAGGCCTGCCCTGCCGGCCTGTACGGCGACAACTGTCGGCATTCCTGCCTCTGC       GGGGCCTGTGTGACCCGCACACGGGCCGCTGCCTCTGCCCAGCCGGCTGGACTGGGGACAAGTGTCAG       AGCCCTGCAGCCTGTGCCAAGGGCACATTCGGGCCTCACTGTGAGGGGCGCTGTGCCTGCCGGTGGGG       AGGCCCCTGCCACCTTGCCACCGGGGCCTGCCTCTGCCCTCCGGGGTGGCGGGGGCCTCATCTTTCTG       CAGCCTGCCTGCGGGGCTGGTTTGGAGAGGCCTGTGCCCAGCGCTGCAGCTGCCCGCCTGGCGCTGCC       TGCCACCACGTCACTGGGGCCTGCCGCTGTCCCCCTGGCTTCACTGGCTCCGGCTGCGAGCAGGCCTG       CCCACCCGGCAGCTTTGGGGAGGACTGTGCGCAGATGTGCCAGTGTCCCGGTGAGAACCCGGCCTGCC       ACCCTGCCACCGGGACCTGCTCATGTGCTGCTGGCTACCACGGCCCCAGCTGCCAGCAACGATGTCCG       CCCGGGCGGTATGGGCCAGGCTGTGAACAGCTGTGTGGGTGTCTCAACGGGGGCTCCTGTGATGCGGC       CACGGGGGCCTGCCGCTGCCCCACTGGGTTCCTCGGGACGGACTGCAACCTCACCTGTCCGCAGGGCC       GCTTCGGCCCCAACTGCACCCACGTGTGTGGGTGTGGGCAGGGGGCGGCCTGCGACCCTGTGACCGGC       ACCTGCCTCTGCCCCCCGGGGAGAGCCGGCGTCCGCTGTGAGCGAGGCTGCCCCCAGAACCGGTTTGG       CGTGGGCTGCGAGCACACCTGCTCCTGCAGAAATGGGGGCCTGTGCCACGCCAGCAACGGCAGCTGCT       CCTGTGGCCTGGGCTGGACGGGGCGGCACTGCGAGCTGGCCTGTCCCCCTGGGCGCTACGGAGCCGCC       TGCCATCTGGAGTGCTCCTGCCACAACAACAGCACGTGTGAGCCTGCCACGGGCACCTGCCGCTGCGG       CCCCGGCTTCTATGGCCAGGCCTGCGAGCACCCCTGTCCCCCTGGCTTCCACGGGGCTGGCTGCCAGG       GGTTGTGCTGGTGTCAACATGGAGCCCCCTGCGACCCCATCAGTGGCCGATGCCTCTGCCCTGCCGGC       TTCCACGGCCACTTCTGTGAGAGGGGGTGTGAGCCAGGTTCATTTGGAGAGGGCTGCCACCAGCGCTG       TGACTGTGACGGGGGGGCACCCTGTGACCCTGTCACCGGTCTCTGCCTTTGCCCACCAGGGCGCTCAG       GAGCCACCTGTAACCTGGATTGCAGAAGGGGCCAGTTTGGGCCCAGCTGCACCCTGCACTGTGACTGC       GGGGGTGGGGCTGACTGCGACCCTGTCAGTGGGCAGTGTCACTGTGTGGATGGCTACATGGGGCCCAC       GTGCCGGGAAGCGGGCACACTGCCCGCCTCCAGCAGACCCACATCCCGGAGCGGTGGACCAGCGAGGC       ACGAATTCCCCGGGCTCGAGGGTAAGCCTATCCCTAACCCTCTCCTCGGTCTCGATTCTACGCGTACC       GGTCATCACCACCATCACCATTGAGTTTAATTCATTGATTT                                         NOV37f, 317004318                       Protein Sequence   SEQ ID NO: 868   1620 aa   MW at 169975.0kD                     HEALATMETDTLLLWVLLLWVPGSTGDAAQPARRARRTKLSRGSSVPPRPLLPLQPGMPHVCAEQELT           LVGRRQPCVQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEG       CLSDVGECANANGGCAGRCRDTVGGFYCRWPPPSHQLQGDGETCQDVDECRTHNGGCQHRCVNTPGSY       LCECKPGFRLHTDSRTCAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRN       GSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGAD       GRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTN       NPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEE       PMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTC       DDCRNGGTCLLGLDGCDCPEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGT       NCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQCVQPH       TQSCDKRDGSCSCKAGFRGERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCG       QECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEAGECEGLWGLGCQEICPACHNAARCD       PETGACLCLPGFVGSRCQDCEAGWYGPSCQTMCSCANDGHCHQDTGHCSCAPGWTGFSCQRACDTGHW       GPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHVSGAC       TCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAESACPAHTYGHNC       SQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGW       AGLACEVECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPHCEGRCA       CRWGGPCHLATGACLCPPGWRGPHLSAACLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGC       EQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGS       CDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQ       NRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGT       CRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGC       HQRCDCDGGAPCDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGY       MGPTCREAGTLPASSRPTSRSGGPARHEFPGLEGKPIPNPLLGLDSTRTGHHHHHH                                     NOV37g, CG56449-01   SEQ ID NO: 869   7337 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 4213                       ATG CCCATGGGACATTCTGACAGGTGGTCTTGGCGTCTCCTGAGGCTGGCACTGCCACTCCCAGTCTG           GTTGCCGGCTGGGGGTGGCCGAGGCGCTGACTCTCCATGTCTCTGTTCCAGGCCCCACGTGTGTGCTG       AGCAGGAGCTGACCCTGGTGGGCCGCCGCCAGCCGTGCGTGCAGGCCTTAAGCCACACGGTGCCGGTG       TGGAAGGCCGGCTGTGGGTGGCAGGCGTGGTGCGTGGGTCATGAGCGGAGGACCGTCTACTACATGGG       CTACAGGCAGGTGTATACCACGGAGGCCCGGACCGTGCTCAGGTGCTGCCGAGGGTGGATGCAGCAGC       CCGACGAGGAGGGCTGCCTCTCGGATGTGGGTGAGTGTGCCAACGCCAACGGGGGCTGTGCGGGTCGG       TGCCGGGACACCGTGGGGGGCTTCTACTGCCGCTGGCCCCCCCCCAGCCACCAGCTGCAGGGTGATGG       CGAGACTTGCCAAGATGTGGACGAATGCCGAACCCACAACGGTGGCTGCCAGCACCGGTGCGTGAACA       CCCCAGGCTCCTACCTCTGTGAGTGCAAGCCCGGCTTCCGGCTCCACACTGACAGCAGGACCTGCGCC       ATTAACTCCTGCGCCCTGGGCAATGGCGGCTGCCAGCACCACTGTGTCCAGCTCACAATCACTCGGCA       TCGCTGCCAGTGCCGGCCCGGGTTCCAGCTCCAGGAGGACGGCAGGCATTGTGTCCGTAGAAGCCCGT       GTGCCAACAGGAACGGCAGCTGCATGCACAGGTGCCAGGTGGTCCGGGGCCTCGCCCGCTGTGAGTGC       CACGTGGGCTATCAGCTAGCAGCGGACGGCAAGGCCTGTGAAGATGTGGACGAATGTGCCGCAGGGCT       GGCCCAGTGTGCCCATGGCTGCCTCAACACCCAGGGGTCCTTCAAGTGCGTGTGTCACGCGGGCTATG       AGCTGGGCGCCGATGGCCGGCAGTGCTACCGTATTGAGATGGAAATCGTGAACAGCTGTGAGGCCAAC       AACGGCGGCTGCTCCCATGGCTGCAGCCACACCAGTGCTGGGCCCCTGTGCACCTGTCCCCGCGGCTA       CGAGCTGGACACAGATCAGAGGACCTGCATCAGATGTCGACGACTGTGCAGACAGCCCGTGCTGCAGC       AGGTGTGCACCAACAACCCTGGCGGGTACGAGTGCGGCTGCTACGCCGGCTACCGGCTCAGTGCCGAT       GGCTGCGGCTGCGAGGATGTGGATGAGTGCGCCTCCAGCCGTGGCGGCTGCGAGCACCACTGCACCAA       CCTGGCCGGCTCCTTCCAGTGCTCCTGCGAGGCCGGCTACCGGCTGCACGAGGACCGTAGGGGCTGCA       GCGCCCTGGAGGAGCCGATGGTGGACCTGGACGGCGAGCTGCCTTTCGTGCGGCCCCTGCCCCACATT       GCCGTGCTCCAGGACGAGCTGCCGCAACTCTTCCAGGATGACGACGTCGGGGCCGATGAGGAAGAGGC       AGAGTTGCGGGGCGAACACACGCTCACAGAGAAGTTTGTCTGCCTGGATGACTCCTTTGGCCATGACT       GCAGCTTGACCTGTGATGACTGCAGGAACGGAGGGACCTGCCTCCTGGGCCTGGATGGCTGTGATTGC       CCCGAGGGCTGGACTGGGCTCATCTGCAATGAGAGTTGTCCTCCGGACACCTTTGGGAAGAACTGCAG       CTTCTCCTAAAGCTGTCAGAATGGTGGGACCTGCGACTCTGTCACGGGGGCCTGCCGCTGCCCCCCGG       GTGTCAGTGGAACTAACTGTGAGGATGGCTGCCCCAAGGGCTACTATGGCAAGCACTGTCGCAAGAAA       TGCAACTGTGCCAACCGGGGCCGGTGCCACCGCCTCTACGGGGCCTGCCTCTGCGACCCAGGGCTCTA       CGAACGCTTCTGCCACCTCGCCTGCCCGCCGTGGGCCTTTGGGCCGGGCTGCTCGGAGGAGTGCCAGT       GTGTGCAGCCCCACACGCAGTCCTGTGACAAGAGGGATGGCAGCTGCTCCTGCAAGGCTAACTTCCGG       GGCGAGCGCTGTCAGGCAGAGTGTGAGCCGGGCTACTTTGGGCCGGGGTGCTGGCAGGCATGCACCTG       CCCAGTGGGCGTGGCCTGTGACTCCGTGAGCGGCGAGTGTGGGAAGCGGTGTCCTGCTGGCTTCCAGG       GAGAGGACTGTGGCCAAGAGTGCCCGGTGGGGACCTTTGGCGTGAACTGCTCGAGCTCCTGCTCCTGT       GGGGGGGCCCCCTGCCACGGGGTCACGGGGCAGTGCCGGTGTCCGCCGGGGAGGACTGGGAAAGACTG       TGAGGCAGGTGAGTGTGAGGGCCTCTGGGGGCTGGGCTGCCAGGAGATCTGCCCAGCATGCCATAACG       CTGCTCGCTGCGACCCTGAGACCGGAGCCTGCCTGTGCCTCCCTGGCTTTGTCGGCAGCCGCTGCCAG       GACTGTGAGGCAGGCTGGTATGGTCCCAGCTGCCAGACAATGTGCTCTTGTGCCGCTGATGGGCACTG       CCACCAAGACACGGGACACTGCAGCTGTGCCCCCGGGTGGACCGGCTTTAGCTGCCAGAGAGCCTGTG       ATACTGGGCACTGGGGACCTGACTGCAGCCACCCCTGCAACTGCAGCGCTGGCCACGGGAGCTGTGAT       GCCATCAGCGGCCTGTGTCTGTGTGAGGCTGGCTACGTGGGCCCGCGGTGCGAGCAGTCAGAGTGTCC       CCAGGGCCACTTTGGGCCCGGCTGTGAGCAGCGGTGCCAGTGTCAGCATGGAGCAGCCTGTGACCACG       TCAGCGGGGCCTGCACCTGCCCGGCCGGCTGGAGGGGCACCTTCTGCGAGCATGCCTGCCCGGCCGGC       TTCTTTGGATTGGACTGTCGCAGTGCCTGCAACTGCACCGCCGGAGCTGCCTGTGATGCCGTGAATGG       CTCCTGCCTCTGCCCCGCTGGCCGCCGGGGCCCCCGCTGTGCCGAGAGTGCCTGCCCAGCCCACACCT       ACGGGCACAATTGCAGCCAGGCCTGTGCCTGCTTTAACGGGGCCTCCTGTGACCCTGTCCACGGGCAG       TGCCACTGTGCCCCTGGCTGGATGGGGCCCTCCTGCCTGCAGGCCTGCCCTGCCGGCCTGTACGGCGA       CAACTGTCGGCATTCCTGCCTCTGCCAGAACGGAGGGACCTGTGACCCTGTCTCAGGCCACTGTGCGT       GCCCAGAGGGCTGGGCCGGCCTGGCCTGTGAGGTAGAGTGCCTCCCCCGGGACGTCAGAGCTGGCTGC       CGGCACAGCGGCGGTTGCCTCAACGGGGGCCTGTGTGACCCGCACACGGGCCGCTGCCTCTGCCCAGC       CGGCTGGACTGGGGACAAGTGTCAGAGCCCTGCAGCCTGTGCCAAGGGCACATTCGGGCCTCACTGTG       AGGGGCGCTGTGCCTGCCGGTGGGGAGGCCCCTGCCACCTTGCCACCGGGGCCTGCCTCTGCCCTCCG       GGGTGGCGGGGGCCTCATCTTTCTGCAGCCTGCCTGCGGGGCTGGTTTGGAGAGGCCTGTGCCCAGCG       CTGCAGCTGCCCGCCTGGCGCTGCCTGCCACCACGTCACTGGGGCCTGCCGCTGTCCCCCTGGCTTCA       CTGGCTCCGGCTGCGAGCAGGCCTGCCCACCCGGCAGCTTTGGGGAGGACTGTGCGCAGATGTGCCAG       TGTCCCGGTGAGAACCCGGCCTGCCACCCTGCCACCGGGACCTGCTCATGTGCTGCTGGCTACCACGG       CCCCAGCTGCCAGCAACGATGTCCGCCCGGGCGGTATGGGCCAGGCTGTGAACAGCTGTGTGGGTGTC       TCAACGGGGGCTCCTGTGATGCGGCCACGGGGGCCTGCCGCTGCCCCACTGGGTTCCTCGGGACGGAC       TGCAACCTCACCTGTCCGCAGGGCCGCTTCGGCCCCAACTGCACCCACGTGTGTGGGTGTGGGCAAAG       GGCGGCCTGCGACCCTGTGACCGGCACCTGCCTCTGCCCCCCGGGGAGAGCCGGCGTCCGCTGTGAGC       GAGGCTGCCCCCAGAACCGGTTTGGCGTGGGCTGCGAGCACACCTGCTCCTGCAGAAATGGGGGCCTG       TGCCACGCCAGCAAGCGGCAGCTGCTCCTGTGGCCTGGGCTGGACGGGGCGGCACTGCGAGCTGGCCT       GTCCCCCTGGGCGCTACGGAGCCGCCTGCCATCTGGAGTGCTCCTGCCACAACAACAGCACGTG TGA   G           CCTGCCACGGGCACCTGCCGCTGCGGCCCCGGCTTCTATGGCCAGGCCTGCGAGCACCCCTGTCCCCC           TGGCTTCCACGGGGCTGGCTGCCAGGGGTTGTGCTGGTGTCAACATGGAGCCCCCTGCGACCCCATCA           GTGGCCGATGCCTCTGCCCTGCCGGCTTCCACGGCCACTTCTGTGAGAGGGGGTGTGAGCCAGGTTCA           CTGCCTTTGCCCACCAGGGCGCTCAGGAGCCACCTGTAACCTGGATTGCAGAAGGGGCCAGTTTGGGC           CCAGCTGCACCCTGCACTGTGACTGCGGGGGTGGGGCTGACTGCGACCCTGTCAGTGGGCAGTGTCAC           TGTGTGGATGGCTACATGGGGCCCACGTGCCGGGAAGGTGGGCCCCTCCGGCTCCCCGAGAACCCGTC           CTTAGCCCAGGGCTCAGCGGGCACACTGCCCGCCTCCAGCAGACCCACATCCCGGAGCGGTGGACCAG           CGAGGCACTAGTAGAGGCAGTCCCGTGGAGCCCGCCTCTCCAGTCCCAGCCAGAGGGGACCCTGGCCT           TTGGTGACCACTGAGAAGGACACTTCACGGGCCCAGAGCTCCTGGTACTGCCCTTCCTTTGAGGGCCG           AGGAGGGCTGTGGACAGCCCAGCAACCTGTCGCTCTTGGAGGCTGGTGTGGCCTTGAGGAGGGAAGAA           TCGCATGGCCGCTGGAAGAGAGGCGCCTCCTGGCCTGGCTCTGCAGAACCCAGGGGCACGCTCTGGGC           CTGGGCTGAGGAAGTCCCGCTCTCCCCGCGGCTCTGAGTTGGACTGAGGACAGGTGTGGGCGCCAGTG           TGGGTGCAGGCGCAGGTGCAGGCACAGGGCCACTGTCCTCCAGGCAGGCTTTTTGGTGCTAGGCCCTG           GGACTGGAAGTCGCCCAGCCCGTATTTATGTAAAGGTATTTATGGGCCACTGCACATGCCCGCTGCAG           CCCTGGGATCAGCTGGAAGCTGCCTGTCATCTCCTGCCCAATCCCCAGAAACCCTGATTCAGGTCTGC           AGGCTCCTGCGGGCTCACCAGGCTGCTGGCTCCGGTACCATGTACCTAAAGGTAAAAAAAGGAGCAGG           CAACCTCCTCGTGGCCTGTGTGTTTGCTGTGTTACGTGGACTCTGTGTGGGCTCCTCCCTGGGGCCCG           GCCAGCATAACGGTGCACCCAGGGACCTCCCAGTGCACCCGGGGCCCTTTGCAGGGGTGGGGGTGCCA           CACAAGTGAAGAAGTTGGGACTCATCTCAGTTCCCAGTGCTATTGAGGAGAACGCTGGGGCTGCATTC           ATTACCGCTGAGACCCAGAGACTGGCTGTTCCCAGAGAATGGCCCAGGGGGAGGAGAACTGGTGTAAA           GGGGCAACCTGGACTGAGGCCGAACTCCCTTGGGCTCACCCCACCCACCCCTACCTGAGCATCAGCAG           TGGGGGGAGGGCAGCATCGCAGGGGCAGGGACTCCCTGGGTGAGGACAGACCAGCCCTCCCGAGCACC           TGGCACTCATGGGCTGAGGCTGACTTCTCCTGGAAGAAGGGCCCAGAGTGGAAGGAAGAGGCAGAGGC           TAGAGGTGGTGGCTGGGGGCTCCTCTGCAGAGTGGGGTGGCCAATGGAGAGGGCTGCACTCACACCGC           ACATAGGAACTCTCTCTCCCTTAAGAAGGCCCCCTTAGGGTCTGGGCTGCCGCCCCCATCACCCTAAA           CCAGCCAAAGGTAGCTGAGGCCCCAGGGCAGACAATTTCACCAGCAGGANGAGGAGGAGTCCAGTGAG           CTTGGTTGCTCACAGACAGCAAGGGAGCTGTCACAGAGGAAGCTGATGAATGGACCGCTGTGGGGAGA           CTTTAAAGTAGAACAGTGATAAGGGAGGGCAGGATGGTGGGGATGCAGAAGCAGCAGCCAGAGAGAGA           CGGACTGGGGTGCAGACGGAGTGTGGAAAACGCATACCTTGAAATGAAGCATCCAGCAGATGGGGTGA           GTGGATACAGCTCAGGAGATTCTCCCAGGAATAGCAGGGAGGCGTAAAGAGAGACAACGTACAGAGAT           AGATGAATGGAAATGGGTAAGGGAGGTGTTCATTCACATCCATCTAACTGCAAAATACAAAAGTAAGA           AGTCATTGACATGAAGCAACGACGACCAAGACGTTCTCAGATCTAAAGGTGAATGATCTCAGTCAGCC           TGGAAATGCACAAGGTGGAAAAATAACATAAAAAAGCCATAAGACCTTGAAGAACATCAATGTCAAAG           ATAAATTCTAAAGTCCCAGAGAAAAAAGAATGGGAATCAAATTGACCTCAGACTATACGTGAGAAACA           CGGAGAGCCAGAAAACTGTGATGTTCCATCCTCAGAGTTTGAAGGAAATATTTGAAGGCTGAATTTTA           CATCCAGCTAAACTATCAAAGGCATGCAAAGTCCATGTTATTCTTAGGCCTTCAAGGCCTCGGCCATT           TTTCTACAGAAAAGCCTGATTTTAAAATGCTCTTAGAGACGTTCTCCAGCCAGAAGAGAAAGAAGCCA           GGAGGGTGCTCTGAGATATTCAGTCACCACAGTTCCCAAATGGCCTAGGAATTCAGAGAGTCAGAATA           TCACCATTACTCCCCAATGGGAACCCCCGACAGTCTCAGCATGGTGTGAGGGTGTGGACGGGGGGCCT           GGCAGGTACCAATCACTCATCCCGCTCAGTGAAGACACAGTGTTCAGCTACGGAAGCCATAAGGCAGG           CCGAGCTTCTGCCCATCCGGAGGAAATCTCAGCTATCCAACGGCGGTCAGGAGCAGAGGAAAATAAAG           CAGAATAACTAGAAAACACGCTCACAGATCCTAATGTTAACGGTTACAAATGACGACGGAAAAACAAA           CTCCTGACCATATATTATATAGTTTCAAGCAGCAAGAAGGAGGATATTGAACATTCTCAACACACATA           ATAAACGCTTGAGATGATGATATGCTCATTACCCTGATTTGATCACTAGACATACCATGTATCAAAAC           ATCACTGTGTATCCGATGAATATCTACAATTATTGTCAATTAAAACATCATTAAAAAACAA                                           NOV37g, CG56449-01                       Protein Sequence   SEQ ID NO: 870   1404 aa   MW at 147886.8kD                     MPMGHSDRWSWRLLRLALPLPVWLPAGGGRGADSPCLCSRPHVCAEQELTLVGRRQPCVQALSHTVPV           WKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEGCLSDVGECANANGGCAGR       CRDTVGGFYCRWPPPSHQLQGDGETCQDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCA       INSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCEC       HVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEAN       NGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNTPGGYECGCYAGYRLSAD       GCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHI       AVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDC       PEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKK       CNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFR       GERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSC       GGAPCHGVTGQCRCPPGRTGEDCEAGECEGLWGLGCQEICPACHNAARCDPETGACLCLPGFVGSRCQ       DCEAGWYGPSCQTMCSCANDGHCHQDTGHCSCAPGWTGFSCQPACDTGHWGPDCSHPCNCSAGHGSCD       ASGLCLCEAGYVTGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAG       FFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAESACPAHTYGHNCSQACACFNGASCDPVHGQ       CHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEVECLPRDVRAGC       RHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPHCEGRCACRWGGPCHLATGACLCPP       GWRGPHLSAACLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQ       CPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTD       CNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGL       CHASKRQLLLWPGLDGAALRAGLSPWALRSRLPSGVLLPQQQHV                                     NOV37h, CG56449-02   SEQ ID NO: 871   7319 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 4195                       ATG CCCATGGGACATTCTGACAGGTGGTCTTGGCGTCTCCTGAGGCTGGCACTGCCACTCCCAGTCTG           GTTGCCGGCTGGGGGTGGCCGAGGCGCTGACTCTCCATGTCTCTGTTCCAGGCCCCACGTGTGTGCTG       AGCAGGAGCTGACCCTGGTGGGCCGCCGCCAGCCGTGCGTGCAGGCCTTAAGCCACACGGTGCCGGTG       TGGAAGGCCGGCTGTGGGTGGCAGGCGTGGTGCGTGGGTCATGAGCGGAGAACCGTCTACTACATGGG       CTACAGGCAGGTGTATACCACGGAGGCCCGGACCGTGCTCAGGTGCTGCCGAGGGTGGACGCAGCAGC       CCGACGAGGAGGGCTGCCTCTCGGCTGAATGCAGCGCCAGCCTCTGTTTTCACGGTGGCCGTTGTGTG       CCAGGCTCAGCCCAGCCGTGTCACTGTCCCCCCGGCTTCCAGGGACCCCGCTGTCAGTATGATGTGGA       CGAATGCCGAACCCACAACGGTGGCTGCCAGCACCGGTGCGTGAACACCCCAGGCTCCTACCTCTGTG       AGTGCAAGCCCGGCTTCCGGCTCCACACTGACAGCAGGACCTGCCTGGCCATTAACTCCTGCGCCCTG       GGCAATGGCGGCTGCCAGCACCACTGTGTCCAGCTCACAATCACTCGGCATCGCTGCCAGTGCCGGCC       CGGGTTCCAGCTCCAGGAGGACGGCAGGCATTGTGTCCGTAGAAGCCCGTGTGCCAACAGGAACGGCA       GCTGCATGCACAGGTGCCAGGTGGTCCGGGGCCTCGCCCGCTGTGAGTGCCACGTGGGCTATCAGCTA       GCAGCGGACGGCAAGGCCTGTGAAGATGTGGACGAATGTGCCGCAGGGCTGGCCCAGTGTGCCCATGG       CTGCCTCAACACCCAGGGGTCCTTCAAGTGCGTGTGTCACGCGGGCTATGAGCTGGGCGCCGATGGCC       GGCAGTGCTACCGTATTGAGATGGAAATCGTGAACAGCTGTGAGGCCAACAACGGCGGCTGCTCCCAT       GGCTGCAGCCACACCAGTGCTGGGCCCCTGTGCACCTGTCCCCGCGGCTACGAGCTGGACACAGATCA       GAGGACCTGCATCAGATGTCGACGACTGTGCAGACAGCCCGTGCTGCAGCAGGTGTGCACCAACAACC       CTGGCGGGTACGAGTGCGGCTGCTACGCCGGCTACCGGCTCAGTGCCGATGGCTGCGGCTGCGAGGAT       GTGGATGAGTGCGCCTCCAGCCGTGGCGGCTGCGAGCACCACTGCACCAACCTGGCCGGCTCCTTCCA       GTGCTCCTGCGAGGCCGGCTACCGGCTGCACGAGGACCGTAGGGGCTGCAGCGCCCTGGAGGAGCCGA       TGGTGGACCTGGACGGCGAGCTGCCTTTCGTGCGGCCCCTGCCCCACATTGCCGTGCTCCAGGACGAG       CTGCCGCAACTCTTCCAGGATGACGACGTCGGGGCCGATGAGGAAGAGGCAGAGTTGCGGGGCGAACA       CACGCTCACAGAGAAGTTTGTCTGCCTGGATGACTCCTTTGGCCATGACTGCAGCTTGACCTGTGATG       ACTGCAGGAACGGAGGGACCTGCCTCCTGGGCCTGGATGGCTGTGATTGCCCCGAGGGCTGGACTGGG       CTCATCTGCAATGAGAGTTGTCCTCCGGACACCTTTGGGAAGAACTGCAGCTTCTCCTGCAGCTGTCA       GAATGGTGGGACCTGCGACTCTGTCACGGGGGCCTGCCGCTGCCCCCCGGGTGTCAGTGGAACTAACT       GTGAGGATGGCTGCCCCAAGGGCTACTATGGCAAGCACTGTCGCAAGAAATGCAACTGTGCCAACCGG       GGCCGGTGCCACCGCCTCTACGGGGCCTGCCTCTGCGACCCAGGGCTCTACGGCCGCTTCTGCCACCT       CGCCTGCCCGCCGTGGGCCTTTGGGCCGGGCTGCTCGGAGGAGTGCCAGTGTGTGCAGCCCCACACGC       AGTCCTGTGACAAGAGGGATGGCAGCTGCTCCTGCAAGGCTGGCTTCCGGGGCGAGCGCTGTCAGGCA       GAGTGTGAGCCGGGCTACTTTGGGCCGGGGTGCTGGCAGGCATGCACCTGCCCAGTGGGCGTGGCCTG       TGACTCCGTGAGCGGCGAGTGTGGGAAGCGGTGTCCTGCTGGCTTCCAGGGAGAGGACTGTGGCCAAG       AGTGCCCGGTGGGGACCTTTGGCGTGAACTGCTCGAGCTCCTGCTCCTGTGGGGGGGCCCCCTGCCAC       GGGGTCACGGGGCAGTGCCGGTGTCCGCCGGGGAGGACTGGGGAAGACTGTGAGGCAGGTGAGTGTGA       GGGCCTCTGGGGGCTGGGCTGCCAGGAGATCTGCCCAGCATGCCATAACGCTGCTCGCTGCGACCCTG       AGACCGGAGCCTGCCTGTGCCTCCCTGGCTTTGTCGGCAGCCGCTGCCAGGACTGTGAGGCAGGCTGG       TATGGTCCCAGCTGCCAGACAATGTGCTCTTGTGCCAATGATGGGCACTGCCACCAAGACACGGGACA       CTGCAGCTGTGCCCCCGGGTGGACCGGCTTTAGCTGCCAGAGAGCCTGTGATACTGGGCACTGGGGAC       CTGACTGCAGCCACCCCTGCAACTGCAGCGCTGGCCACGGGAGCTGTGATGCCATCAGCGGCCTGTGT       CTGTGTGAGGCTGGCTACGTGGGCCCGCGGTGCGAGCAGTCAGAGTGTCCCCAGGGCCACTTTGGGCC       CGGCTGTGAGCAGCGGTGCCAGTGTCAGCATGGAGCAGCCTGTGACCACGTCAGCGGGGCCTGCACCT       GCCCGGCCGGCTGGAGGGGCACCTTCTGCGAGCATGCCTGCCCGGCCGGCTTCTTTGGATTGGACTGT       CGCAGTGCCTGCAACTGCACCGCCGGAGCTGCCTGTGATGCCGTGAATGGCTCCTGCCTCTGCCCCGC       TGGCCGCCGGGGCCCCCGCTGTGCCGAGAGTGCCTGCCCAGCCCACACCTACGGGCACAATTGCAGCC       AGGCCTGTGCCTGCTTTAACGGGGCCTCCTGTGACCCTGTCCACGGGCAGTGCCACTGTGCCCCTGGC       TGGATGGGGCCCTCCTGCCTGCAGGCCTGCCCTGCCGGCCTGTACGGCGACAACTGTCGGCATTCCTG       CCTCTGCCAGAACGGAGGGACCTGTGACCCTGTCTCAGGCCACTGTGCGTGCCCAGAGGGCTGGGCCG       GCCTGGCCTGTGAGGTAGAGTGCCTCCCCCGGGACGTCAGAGCTGGCTGCCGGCACAGCGGCGGTTGC       CTCAACGGGGGCCTGTGTGACCCGCACACGGGCCGCTGCCTCTGCCCAGCCGGCTGGACTGGGGACAA       GTGTCAGAGCCCTGCAGCCTGTGCCAAGGGCACATTCGGGCCTCACTGTGAGGGGCGCTGTGCCTGCC       GGTGGGGAGGCCCCTGCCACCTTGCCACCGGGGCCTGCCTCTGCCCTCCGGGGTGGCGGGGGCCTCAT       CTTTCTGCAGCCTGCCTGCGGGGCTGGTTTGGAGAGGCCTGTGCCCAGCGCTGCAGCTGCCCGCCTGG       CGCTGCCTGCCACCACGTCACTGGGGCCTGCCGCTGTCCCCCTGGCTTCACTGGCTCCGGCTGCGAGC       AGGCCTGCCCACCCGGCAGCTTTGGGGAGGACTGTGCGCAGATGTGCCAGTGTCCCGGTGAGAACCCG       GCCTGCCACCCTGCCACCGGGACCTGCTCATGTGCTGCTGGCTACCACGGCCCCAGCTGCCAGCAACG       ATGTCCGCCCGGGCGGTATGGGCCAGGCTGTGAACAGCTGTGTGGGTGTCTCAACGGGGGCTCCTGTG       ATGCGGCCACGGGGGCCTGCCGCTGCCCCACTGGGTTCCTCGGGACGGACTGCAACCTCACCTGTCCG       CAGGGCCGCTTCGGCCCCAACTGCACCCACGTGTGTGGGTGTGGGCAGGGGGCGGCCTGCGACCCTGT       GACCGGCACCTGCCTCTGCCCCCCGGGGAGAGCCGGCGTCCGCTGTGAGCGAGGCTGCCCCCAGAACC       GGTTTGGCGTGGGCTGCGAGCACACCTGCTCCTGCAGAAATGGGGGCCTGTGCCACGCCAGCAAGCGG       CAGCTGCTCCTGTGGCCTGGGCTGGACGGGGCGGCACTGCGAGCTGGCCTGTCCCCCTGGGCGCTACG       GAGCCGCCTGCCATCTGGAGTGCTCCTGCCACAACAACAGCACGTG TGA   GCCTGCCACGGGCACCTGC           CGCTGCGGCCCCGGCTTCTATGGCCAGGCCTGCGAGCACCCCTGTCCCCCTGGCTTCCACGGGGCTGG           CTGCCAGGGGTTGTGCTGGTGTCAACATGGAGCCCCCTGCGACCCCATCAGTGGCCGATGCCTCTGCC           CTGCCGGCTTCCACGGCCACTTCTGTGAGAGGGGGTGTGAGCCAGGTTCATTTGGAGAGGGCTGCCAC           CAGCGCTGTGACTGTGACGGGGGGGCACCCTGTGACCCTGTCACCGGTCTCTGCCTTTGCCCACCAGG           GCGCTCAGGAGCCACCTGTAACCTGGATTGCAGAAGGGGCCAGTTTGGGCCCAGCTGCACCCTGCACT           GTGACTGCGGGGGTGGGGCTGACTGCGACCCTGTCAGTGGGCAGTGTCACTGTGTGGATGGCTACATG           GGCAACACTGCCCGCCTCCAGCAGACCCACATCCCGGAGCGGTGGACCAGCGAGGCACTAGTAGAGGC           AGTCCCGTGGAGCCCGCCTCTCCAGTCCCAGCCAGAGGGGACCCTGGCCTTTGGTGACCACTGAGAAG           GACACTTCACGGGCCCAGAGCTCCTGGTACTGCCCTTCCTTTGAGGGCCGTGGAGGGCTGTGGACAGC           CCAGCAACCTGTCGCTCTTGGAGGCTGGTGTGGCCTTGAGGAGGGAAGCCTCGCATGGCCGCTGGAAG           AGAGGCGCCTCCTGGCCTGGCTCTGCAGAACCCAGGGGCACGCTCTGGGCCTGGGCTGAGGAAGTCCC           GCTCTCCCCGCGGCTCTGAGTTGGACTGAGGACAGGTGTGGGCGCCAGTGTGGGTGCAGGCGCAGGTG           AGGCACAAGGGCCACTGTCCTCCAGGCAGGCTTTTTGGTGCTAGGCCCTGGGACTGGAAGTCGCCCAG           CCCGTATTTATGTAAAGGTATTTATGGGCCACTGCACATGCCCGCTGCAGCCCTGGGATCAGCTGGAA           GCTGCCTGTCATCTCCTGCCCAATCCCCAGAAACCCTGATTCAGGTCTGCAGGCTCCTGCGGGCTCAC           CAGGCTGCTGGCTCCGGTACCATGTAAACCTAGGAAGGTAAAGGAGCAGGCAACCTCCTCGTGGCCTG           TGTGTTTGCTGTGTTACGTGGACTCTGTGTGGGCTCCTCCCTGGGGCCCGGCCAGCATAACGGTGCAC           CCAGGGACCTCCCAGTGCACCCGGGGCCCTTTGCAGGGGTGGGGGTGCCACACAAGTGAAGAAGTTGG           GACTCATCTCAGTTCCCAGTGCTATTGAGGAGAACGCTGGGGCTGCATTCATTACCGCTGAGACCCAG           AGACTGGCTGTTCCCAGAGAATGGCCCAGGGGGAGGAGGGCTGGTGTGGAGGGGCAACCTGGACTGAG           GCCGAACTCCCTTGGGCTCACCCCACCCACCCCTACCTGAGCATCAGCAGTGGGGGGAGGGCAGCATC           GCAGGGGCAGGGACTCCCTGGGTGAGGACAGACCAGCCCTCCCGAGCACCTGGCACTCATGGGCTGAG           GCTGACTTCTCCTGGAAGAAGGGCCCAGAGTGGAAGGAAGAGGCAGAGGGTAGAGGTGGTGGCTGGGG           GCTCCTCTGCAGAGTGGGGTGGCCAATGGAGAGGGCTGCACTCACACCGCAACATAGGACTCTCTCTC           CCTTAAGAAGGCCCCCTTAGGGTCTGGGCTGCCGCCCCCATCACCCTAAAACCAGCCAAGGTAGCTGA           GGCCCCAGGGCAGACAATTTCACCAGCAGGANGAGGAGGAGTCCAGTGAGCTTGGTTGCTCACAGACA           GCAAGGGAGCTGTCACAGAGGAAGCTGATGAATGGACCGCTGTGGGGAGACTTTAAAGTAGAACAGTG           ATAAGGGAGGGCAGGATGGTGGGGATGCAGAAGCAGCAGCCAGAGAGAGACGGACTGGGGTGCAGACC           GAGTGTGGAAAACGCATACCTTGAAATGAAGCATCCAGCAGATGGGGTGAGTGGATACAGCTCAGGAG           ATTCTCCCAGGAATAGCAGGGAGGCGTAAAGAGAGACAACGTACAGAGATAGATGAATGGAAATGGGT           AAGGGAGGTGTTCATTCACATCCATCTAACTGCAAAATACAAAAGTAAGAAGTCATTGACATGAAGCA           ACGACGACCAAGACGTTCTCAGATCTAAAGGTGAATGATCTCAGTCAGCCTGGAAATGCACAAGGTGC           AAAAATAACATAAAAAAGCCATAAGACCTTGAAGAACATCAATGTCAAAGATAAATTCTAAAGTCCCA           GAGAAAAAAGAATGGGAATCAAATTGACCTCAGACTATACGTGAGAAACACGGAGAGCCAGAAAACTG           TGATGTTCCATCCTCAGAGTTTGAAGGAAATATTTGAAGGCTGAATTTTACATCCAGCTAAACTATCA           AAGGCATGCAAAGTCCATGTTATTCTTAGGCCTTCAAGGCCTCGGCCATTTTTCTACAGAAAAGCCTG           ATTTTAAAATGCTCTTAGAGACGTTCTCCAGCCAGAAGAGAAAGAAGCCAGGAGGGTGCTCTGAGATA           TTCAGTCACCACAGTTCCCAAATGGCCTAGGAATTCAGAGAGTCAGAATATCACCATTACTCCCCAAT           GGGAACCCCCGACAGTCTCAGCATGGTGTGAGGGTGTGGACGGGGGGCCTGGCAGGTACCAATCACTC           ATCCCGCTCAGTGAAGACACAGTGTTCAGCTACGGAAGCCATAAGGCAGGCCGAGCTTCTGCCCATCC           GGAGGAAATCTCAGCTATCCAACGGCGGTCAGGAGCAGAGGAAAATAAAGCAGAATAACTAGAAAACA           CGCTCACAGATCCTAATGTTAACGGTTACAAATGACGACGGAAAAACAAACTCCTGACCATATATTAT           ATAGTTTCAAGCAGCAAGAAGGAGGATATTGAACATTCTCAACACACATAATAAACGCTTGAGATGAT           GATATGCTCATTACCCTGATTTGATCACTAGACATNCCATGTATCAAAACATCACTGTGTATCCGATC           AATATCTACAATTATTGTCAATTAAAAACATCATTAAAAACAA                                           NOV37h, CG56449-02                       Protein Sequence   SEQ ID NO: 872   1398 aa   MW at 147208.2kD                     MPMGHSDRWSWRLLRLALPLPVWLPAGGGRGADSPCLCSRPHVCAEQELTLVGRRQPCVQALSHTVPV           WKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWTQQPDEEGCLSAECSASLCFHGGRCV       PGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCAL       GNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVPRSPCANRNGSCMHRCQVVRGLARCECHVGYQL       AADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSH       GCSHTSAGPLCTCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCED       VDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHIAVLQDE       LPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTG       LICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANR       GRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQA       ECEPGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCH       GVTGQCRCPPGRTGEDCEAGECEGLWGLGCQEICPACHNAARCDPETGACLCLPGFVGSRCQDCEAGW       YGPSCQTMCSCANDGHCHQDTGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLC       LCEAGYVGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHTSGACTCPAGWRGTFCEHACPAGFFGLDC       RSACNCTAGAACDAVNGSCLCPAGRRGPRCAESACPAHTYGHNCSQACACFNGASCDPVHGQCHCAPG       WMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEVECLPRDVRAGCRHSGGC       LNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPFCEGRCACRWGGPCHLATGACLCPPGWRGPH       LSAACLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENP       ACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCP       QGRFGPNCTHCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASKR       QLLLWPGLDGAALRAGLSPWALRSRLPSGVLLPQQQHV                                     NOV37i, CG56449-03   SEQ ID NO: 873   4733 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAG at 4351                       ATG CCCATGGGACATTCTGACAGGTGGTCTTGGCGTCTCCTGAGGCTGGCACTGCCACTCCCAGTCTG           GTTGCCGGCTGGGGGTGGCCGAGGCGCTGACTCTCCATGTCTCTGTTCCAGGCCCCACGTGTGTGCTG       TGGAAGGCCGGCTGTGGGTGGCAGGCGTGGTGCGTGGGTCATGAGCGGAGAACCGTCTACTACATGGG       CTACAGGCAGGTGTATACCACGGAGGCCCGGACCGTGCTCAGGTGCTGCCGAGGGTGGACGCAGCAGC       CCGACGAGGAGGGCTGCCTCTCGGCTGAATGCAGCGCCAGCCTCTGTTTTCACGGTGGCCGTTGTGTG       CCAGGCTCAGCCCAGCCGTGTCACTGTCCCCCCGGCTTCCAGGGACCCCGCTGTCAGTATGATGTGGA       CGAATGCCGAACCCACAACGGTGGCTGCCAGCACCGGTGCGTGAACACCCCAGGCTCCTACCTCTGTG       AGTGCAAGCCCGGCTTCCGGCTCCACACTGACAGCAGGACCTGCCTGGCCATTAACTCCTGCGCCCTG       GGCAATGGCGGCTGCCAGCACCACTGTGTCCAGCTCACAATCACTCGGCATCGCTGCCAGTGCCGGCC       CGGGTTCCAGCTCCAGGAGGACGGCAGGCATTGTGTCCGTAGAAGCCCGTGTGCCAACAGGAACGGCA       GCTGCATGCACAGGTGCCAGGTGGTCCGGGGCCTCGCCCGCTGTGAGTGCCACGTGGGCTATCAGCTA       GCAGCGGACGGCAAGGCCTGTGAAGATGTGGACGAATGTGCCGCAGGGCTGGCCCAGTGTGCCCATGG       CTGCCTCAACACCCAGGGGTCCTTCAAGTGCGTGTGTCACGCGGGCTATGAGCTGGGCGCCGATGGCC       GGCAGTGCTACCGTATTGAGATGGAAATCGTGAACAGCTGTGAGGCCAACAACGGCGGCTGCTCCCAT       GGCTGCAGCCACACCAGTGCTGGGCCCCTGTGCACCTGTCCCCGCGGCTACGAGCTGGACACAGATCA       GAGGACCTGCATCAGATGTCGACGACTGTGCAGACAGCCCGTGCTGCAGCAGGTGTGCACCAACAACC       CTGGCGGGTACGAGTGCGGCTGCTACGCCGGCTACCGGCTCAGTGCCGATGGCTGCGGCTGCGAGGAT       GTGGATGAGTGCGCCTCCAGCCGTGGCGGCTGCGAGCACCACTGCACCAACCTGGCCGGCTCCTTCCA       GTGCTCCTGCGAGGCCGGCTACCGGCTGCACGAGGACCGTAGGGGCTGCAGCGCCCTGGAGGAGCCGA       TGGTGGACCTGGACGGCGAGCTGCCTTTCGTGCGGCCCCTGCCCCACATTGCCGTGCTCCAGGACGAG       CTGCCGCAACTCTTCCAGGATGACGACGTCGGGGCCGATGAGGAAGAGGCAGAGTTGCGGGGCGAACA       CACGCTCACAGAGAAGTTTGTCTGCCTGGATGACTCCTTTGGCCATGACTGCAGCTTGACCTGTGATG       ACTGCAGGAACGGAGGGACCTGCCTCCTGGGCCTGGATGGCTGTGATTGCCCCGAGGGCTGGACTGGG       CTCATCTGCAATGAGAGTTGTCCTCCGGACACCTTTGGGAAGAACTGCAGCTTCTCCTGCAGCTGTCA       GAATGGTGGGACCTGCGACTCTGTCACGGGGGCCTGCCGCTGCCCCCCGGGTGTCAGTGGAACTAACT       GTGAGGATGGCTGCCCCAAGGGCTACTATGGCAAGCACTGTCGCAAGAAATGCAACTGTGCCAACCGG       GGCCGGTGCCACCGCCTCTACGGGGCCTGCCTCTGCGACCCAGGGCTCTACGGCCGCTTCTGCCACCT       CGCCTGCCCGCCGTGGGCCTTTGGGCCGGGCTGCTCGGAGGAGTGCCAGTGTGTGCAGCCCCACACGC       AGTCCTGTGACAAGAGGGATGGCAGCTGCTCCTGCAAGGCTGGCTTCCGGGGCGAGCGCTGTCAGGCA       GAGTGTGAGCTGGGCTACTTTGGGCCGGGGTGCTGGCAGGCATGCACCTGCCCAGTGGGCGTGGCCTG       TGACTCCGTGAGCGGCGAGTGTGGGAAGCGGTGTCCTGCTGGCTTCCAGGGAGAGGACTGTGGCCAAG       AGTGCCCGGTGGGGACGTTTGGCGTGAACTGCTCGAGCTCCTGCTCCTGTGGGGGGGCCCCCTGCCAC       GGGGTCACGGGGCAGTGCCGGTGTCCACCGGGGAGGACTGGGGAAGACTGTGAGGCAGATTGTCCCGA       GGGCCGCTGGGGGCTGGGCTGCCAGGAGATCTGCCCAGCATGCCAGCACGCTGCCCGCTGCGACCCTG       AGACCGGAGCCTGCCTGTGCCTCCCTGGCTTCGTCGGCAGCCGCTGCCAGGACGTGTGCCCAGCAGGC       TGGTATGGTCCCAGCTGCCAGACAAGGTGCTCTTGTGCCAATGATGGGCACTGCCACCCAGCCACCGG       ACACTGCAGCTGTGCCCCCGGGTGGACCGGCTTTAGCTGCCAGAGAGCCTGTGATACTGGGCACTGGG       GACCTGACTGCAGCCACCCCTGCAACTGCAGCGCTGGCCACGGGAGCTGTGATGCCATCAGCGGCCTG       TGTCTGTGTGAGGCTGGCTACGTGGGCCCGCGGTGCGAGCAGCAGTGTCCCCAGGGCCACTTTGGGCC       CGGCTGTGAGCAGCTGTGCCAGTGTCAGCATGGAGCAGCCTGTGACCACGTCAGCGGGGCCTGCACCT       GCCCGGCCGGCTGGAGGGGCACCTTCTGCGAGCATGCCTGCCCGGCCGGCTTCTTTGGATTGGACTGT       CGTAGTGCCTGCAACTGCACCGCCGGAGCTGCCTGTGATGCCGTGAATGGCTCCTGCCTCTGCCCCGC       TGGCCGCCGGGGCCCCCGCTGTGCCGAGACCTGCCCTGCCGGCCTGTACGGCGACAACTGTCGGCATT       CCTGCCTCTGCCAGAACGGAGGGACCTGTGACCCTGTCTCAGGCCACTGTGCGTGCCCAGAGGGCTGG       GCCGGCCTGGCCTGTGAGAAGGAGTGCCCCCCCCGGGACGTCAGAGCTGGCTGCCGGCACAGCGGTGG       TTGCCTCAACGGGGGCCTGTGTGACCCGCACACGGGCCGCTGCCTCTGCCCAGCCGGCTGGGCTGGGG       ACAAGTGTCAGAGCCCCTGCCTGCGGGGCTGGTTTGGAGAGGCCTGTGCCCAGCACTGCAGCTGCCCG       CCTGGCGCTGCCTGCCACCACGTCACTGGGGCCTGCCGCTGTCCCCCTGGCTTCACTGGCTCCGGCTG       CGAGCAGGGATGTCCGCCCGGGCGGTATGGGCCAGGCTGTGAACAGCTGTGTGGGTGTCTCAACGGGG       GCTCCTGTGATGCGGCCACGGGGGCCTGCCGCTGCCCCACTGGGTTCCTCGGGACGGACTGCAACCTC       ACCTGTCCGCAGGGCCGCTTCGGCCCCAACTGCACCCACGTGTGTGGGTGTGGGCAGGGGGCGGCCTG       CGACCCTGTGACCGGCACCTGCCTCTGCCCCCCGGGGAGAGCCGGCGTCCGCTGTGAGCGAGGCTGCC       CCCAGAACCGGTTTGGCGTGGGCTGCGAGCACACCTGCTCCTGCAGAAATGGGGGCCTGTGCCACGCC       AGCAACGGCAGCTGCTCCTGTGGCCTGGGCTGGACGGGGCGGCACTGCGAGCTGGCCTGTCCCCCTGG       GCGCTACGGAGCCGCCTGCCATCTGGAGTGCTCCTGCCACAACAACAGCACGGGTGAGCCTGCCACGG       GCACCTGCCGCTGCGGCCCCGGCTTCTATGGCCAGGCCTGCGAGCACCCCTGTCCCCCTGGCTTCCAC       GGGGCTGGCTGCCAGGGGTTGTGCTGGTGTCAACATGGAGCCCCCTGCGACCCCATCAGTGGCCGATG       CCTCTGCCCTGCCGGCTTCCACGGCCACTTCTGTGAGAGGGGGTGTGAGCCAGGTTCATTTGGAGAGG       GCTGCCACCAGCGCTGTGACTGTGACGGGGGGGCACCCTGTGACCCTGTCACCGGTCTCTGCCTTTGC       CCACCAGGGCGCTCAGGAGCCACCTGTAACCTGGATTGCAGAAGGGGCCAGTTTGGGCCCAGCTGCAC       CCTGCACTGTGACTGCGGGGGTGGGGCTGACTGCGACCCTGTCAGTGGGCAGTGTCACTGTGTGGATG       GCTACATGGGGCCCACGTGCCGGGAAGGTGGGCCCCTCCGGCTCCCCGAGAACCCGTCCTTAGCCCAG       GGCTCAGCGGGCACACTGCCCGCCTCCAGCAGACCCACATCCCGGAGCGGTGGACCAGCGAGGCAC TA           G   TAGAGGCAGTCCCGTGGAGCCCGCCTCTCCAGTCCCAGCCAGAGGGGACCCTGGCCTTTGGTGACCA           CTGAGAAGGACACTTCACGGGCCCAGAGCTCCTGGTACTGCCCTTCCTTTGAGGGCCGTGGAGGGCTC           TGGACAGCCCAGCAACCTGTCGCTCTTGGAGGCTGGTGTGGCCTTGAGGAGGGAAGCCTCGCATGGCC           GCTGGAAGAGAGGCGCCTCCTGGCCTGGCTCTGCAGAACCCAGGGGCACGCTCTGGGCCTGGGCTGAG           GAAGTCCCGCTCTCCCCGCGGCTCTGAGTTGGACTGAGGACAGGTGTGGGCGCCAGTGTGGGTGCAGG           CGCAGGTGCAGGCACAGGGCCACTGTCCTCCAGGCAGGCTT                                           NOV37i, CG56449-03                       Protein Sequence   SEQ ID NO: 874   1450 aa   MW at 152213.4kD                     MPMGHSDRWSWRLLRLALPLPVWLPAGGGRGADSPCLCSRPHVCAEQELTLVGRRQPCVQALSHTVPV           WKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWTQQPDEEGCLSAECSASLCFHGGRCV       PGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCAL       GNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGILACECHVGYQL       AADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSH       GCSHTSAGPLCTCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCED       VDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHIAVLQDE       LPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTG       LICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANR       GRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQA       ECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCH       GVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAG       WYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGL       CLCEAGYVGPRCEQQCPQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDC       RSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGW       AGLLACEKECPPRDVPAGCRHSGGCLNGGCDPHTGRCLCPAGWAGDKCQSPCLRGWFGEACAQHCSCP       PGAACHHVTGACRCPPGFTGSGCEQGCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNL       TCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHA       SNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTGEPATGTCRCGPGFYGQACEHPCPPGFH       GAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLC       PPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCNCVDGYMGPTCREGGPLRLPENPSLAQ       GSAGTLPASSRPTSRSGGPARH                                     NOV37j, CG56449-05   SEQ ID NO: 875   522 bp           DNA Sequence   ORF Start: ATG at 29   ORF Stop: at 515                       GGATCCGTGCCTCGCTGGTCCACCGCTC   ATG GCTCCTGCCTCTGCCCCGCTGGCCGCCGGGGCCCCCG           CTGTGCCGAGACCTGCCCTGCCGGCCTGTACGGCGACAACTGTCGGCATTCCTGCCTCTGCCAGAACG       GAGGGACCTGTGACCCTGTCTCAGGCCTGCGAGCACCCCTGTCCCCCTGGCTTCCACGGGGCTGGCTG       CCAGGGGTTGTGCTGGTGTCAACATGGAGCCCCCTGCGACCCCATCAGTGGCCGATGCCTCTGCCCTG       CCGGCTTCCACGGCCACTTCTGTGAGAGGGATTGCAGAAGGGGCCAGTTTGGGCCCAGCTGCACCCTG       CACTGTGACTGCGGGGGTGGGGCTGACTGCGACCCTGTCAGTGGGCAGTGTCACTGTGTGGATGGCTA       CATGGGGCCCACGTGCCGGGAAGGTGGGCCCCTCCGGCTCCCCGAGAACCCGTCCTTAGCCCAGGGCT       CAGCGGGCACACTGCCCGCCTCCAGCAGACCCACATCCCGC TCGAG                                           NOV37l, CG56449-05                       Protein Sequence   SEQ ID NO: 876   162 aa   MW at 16251.2kD                     MAPASAPLAAGAPAVPRPALPACTATTVGIPASARTEGPVTLSQACEHPCPPGFHGAGCQGLCWCQHG           APCDPISGRCLCPAGFHGHFCERDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGG       PLRLPENPSLAQGSAGTLPASSRPTS                                     NOV37k, CG56449-06   SEQ ID NO: 877   7334 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 4210                       ATG CCCATGGGACATTCTGACAGGTGGTCTTGGCGTCTCCTGAGGCTGGCACTGCCACTCCCAGTCTG           GTTGCCGGCTGGGGGTGGCCGAGGCGCTGACTCTCCATGTCTCTGTTCCAGGCCCCACGTGTGTGCTG       AGCAGGAGCTGACCCTGGTGGGCCGCCGCCAGCCGTGCGTGCAGGCCTTAAGCCACACGGTGCCGGTG       TGGAAGGCCGGCTGTGGGTGGCAGGCGTGGTGCGTGGGTCATGAGCGGAGGACCGTCTACTACATGGG       CTACAGGCAGGTGTATACCACGGAGGCCCGGACCGTGCTCAGGTGCTGCCGAGGGTGGATGCAGCAGC       CCGACGAGGAGGGCTGCCTCTCGGATGTGGGTGAGTGTGCCAACGCCAACGGGGGCTGTGCGGGTCGG       TGCCGGGACACCGTGGGGGGCTTCTACTGCCGCTGGCCCCCCCCCAGCCACCAGCTGCAGGGTGATGG       CGAGACTTGCCAAGATGTGGACGAATGCCGAACCCACAACGGTGGCTGCCAGCACCGGTGCGTGAACA       CCCCAGGCTCCTACCTCTGTGAGTGCAAGCCCGGCTTCCGGCTCCACACTGACAGCAGGACCTGCGCC       ATTAACTCCTGCGCCCTGGGCAATGGCGGCTGCCAGCACCACTGTGTCCAGCTCACAATCACTCGGCA       TCGCTGCCAGTGCCGGCCCGGGTTCCAGCTCCAGGAGGACGGCAGGCATTGTGTCCGTAGAAGCCCGT       GTGCCAACAGGAACGGCAGCTGCATGCACAGGTGCCAGGTGGTCCGGGGCCTCGCCCGCTGTGAGTGC       CACGTGGGCTATCAGCTAGCAGCGGACGGCAAGGCCTGTGAAGATGTGGACGAATGTGCCGCAGGGCT       GGCCCAGTGTGCCCATGGCTGCCTCAACACCCAGGGGTCCTTCAAGTGCGTGTGTCACGCGGGCTATG       AGCTGGGCGCCGATGGCCGGCAGTGCTACCGTATTGAGATGGAAATCGTGAACAGCTGTGAGGCCAAC       AACGGCGGCTGCTCCCATGGCTGCAGCCACACCAGTGCTGGGCCCCTGTGCACCTGTCCCCGCGGCTA       CGAGCTGGACACAGATCAGAGGACCTGCATCAGATGTCGACGACTGTGCAGACAGCCCGTGCTGCAGC       AGGTGTGCACCAACAACCCTGGCGGGTACGAGTGCGGCTGCTACGCCGGCTACCGGCTCAGTGCCGAT       GGCTGCGGCTGCGAGGATGTGGATGAGTGCGCCTCCAGCCGTGGCGGCTGCGAGCACCACTGCACCAA       CCTGGCCGGCTCCTTCCAGTGCTCCTGCGAGGCCGGCTACCGGCTGCACGAGGACCGTAGGGGCTGCA       GCGCCCTGGAGGAGCCGATGGTGGACCTGGACGGCGAGCTGCCTTTCGTGCGGCCCCTGCCCCACATT       GCCGTGCTCCAGGACGAGCTGCCGCAACTCTTCCAGGATGACGACGTCGGGGCCGATGAGGAAGAGGC       AGAGTTGCGGGGCGAACACACGCTCACAGAGAAGTTTGTCTGCCTGGATGACTCCTTTGGCCATGACT       GCAGCTTGACCTGTGATGACTGCAGGAACGGAGGGACCTGCCTCCTGGGCCTGGATGGCTGTGATTGC       CCCGAGGGCTGGACTGGGCTCATCTGCAATGAGAGTTGTCCTCCGGACACCTTTGGGAAGAACTGCAG       CTTCTCCTGCAGCTGTCAGAATGGTGGGACCTGCGACTCTGTCACGGGGGCCTGCCGCTGCCCCCCGG       GTGTCAGTGGAACTAACTGTGAGGATGGCTGCCCCAAGGGCTACTATGGCAAGCACTGTCGCAAGAAA       TGCAACTGTGCCAACCGGGGCCGGTGCCACCGCCTCTACGGGGCCTGCCTCTGCGACCCAGGGCTCTA       CGGCCGCTTCTGCCACCTCGCCTGCCCGCCGTGGGCCTTTGGGCCGGGCTGCTCGGAGGAGTGCCAGT       GTGTGCAGCCCCACACGCAGTCCTGTGACAAGAGGGATGGCAGCTGCTCCTGCAAGGCTGGCTTCCGG       GGCGAGCGCTGTCAGGCAGAGTGTGAGCCGGGCTACTTTGGGCCGGGGTGCTGGCAGGCATGCACCTG       CCCAGTGGGCGTGGCCTGTGACTCCGTGAGCGGCGAGTGTGGGAAGCGGTGTCCTGCTGGCTTCCAGG       GAGAGGACTGTGGCCAAGAGTGCCCGGTGGGGACCTTTGGCGTGAACTGCTCGAGCTCCTGCTCCTGT       GGGGGGGCCCCCTGCCACGGGGTCACGGGGCAGTGCCGGTGTCCGCCGGGGAGGACTGGGGAAGACTG       TGAGGCAGGTGAGTGTGAGGGCCTCTGGGGGCTGGGCTGCCAGGAGATCTGCCCAGCATGCCATAACG       CTGCTCGCTGCGACCCTGAGACCGGAGCCTGCCTGTGCCTCCCTGGCTTTGTCGGCAGCCGCTGCCAG       GACTGTGAGGCAGGCTGGTATGGTCCCAGCTGCCAGACAATGTGCTCTTGTGCCAATGATGGGCACTG       CCACCAAGACACGGGACACTGCAGCTGTGCCCCCGGGTGGACCGGCTTTAGCTGCCAGAGAGCCTGTG       ATACTGGGCACTGGGGACCTGACTGCAGCCACCCCTGCAACTGCAGCGCTGGCCACGGGAGCTGTGAT       GCCATCAGCGGCCTGTGTCTGTGTGAGGCTGGCTACGTGGGCCCGCGGTGCGAGCAGTCAGAGTGTCC       CCAGGGCCACTTTGGGCCCGGCTGTGAGCAGCGGTGCCAGTGTCAGCATGGAGCAGCCTGTGACCACG       TCAGCGGGGCCTGCACCTGCCCGGCCGGCTGGAGGGGCACCTTCTGCGAGCATGCCTGCCCGGCCGGC       TTCTTTGGATTGGACTGTCGCAGTGCCTGCAACTGCACCGCCGGAGCTGCCTGTGATGCCGTGAATGG       CTCCTGCCTCTGCCCCGCTGGCCGCCGGGGCCCCCGCTGTGCCGAGACCTGCCCAGCCCACACCTACG       GGCACAATTGCAGCCAGGCCTGTGCCTGCTTTAACGGGGCCTCCTGTGACCCTGTCCACGGGCAGTGC       CACTGTGCCCCTGGCTGGATGGGGCCCTCCTGCCTGCAGGCCTGCCCTGCCGGCCTGTACGGCGACAA       CTGTCGGCATTCCTGCCTCTGCCAGAACGGAGGGACCTGTGACCCTGTCTCAGGCCACTGTGCGTGCC       CAGAGGGCTGGGCCGGCCTGGCCTGTGAGGTAGAGTGCCTCCCCCGGGACGTCAGAGCTGGCTGCCGG       CACAGCGGCGGTTGCCTCAACGGGGGCCTGTGTGACCCGCACACGGGCCGCTGCCTCTGCCCAGCCGG       CTGGACTGGGGACAAGTGTCAGAGCCCTGCAGCCTGTGCCAAGGGCACATTCGGGCCTCACTGTGAGG       GGCGCTGTGCCTGCCGGTGGGGAGGCCCCTGCCACCTTGCCACCGGGGCCTGCCTCTGCCCTCCGGGG       TGGCGGGGGCCTCATCTTTCTGCAGCCTGCCTGCGGGGCTGGTTTGGAGAGGCCTGTGCCCAGCGCTG       CAGCTGCCCGCCTGGCGCTGCCTGCCACCACGTCACTGGGGCCTGCCGCTGTCCCCCTGGCTTCACTG       GCTCCGGCTGCGAGCAGGCCTGCCCACCCGGCAGCTTTGGGGAGGACTGTGCGCAGATGTGCCAGTGT       CCCGGTGAGAACCCGGCCTGCCACCCTGCCACCGGGACCTGCTCATGTGCTGCTGGCTACCACGGCCC       CAGCTGCCAGCAACGATGTCCGCCCGGGCGGTATGGGCCAGGCTGTGAACAGCTGTGTGGGTGTCTCA       ACGGGGGCTCCTGTGATGCGGCCACGGGGGCCTGCCGCTGCCCCACTGGGTTCCTCGGGACGGACTGC       AACCTCACCTGTCCGCAGGGCCGCTTCGGCCCCAACTGCACCCACGTGTGTGGGTGTGGGCAGGGGGC       GGCCTGCGACCCTGTGACCGGCACCTGCCTCTGCCCCCCGGGGAGAGCCGGCGTCCGCTGTGAGCGAG       GCTGCCCCCAGAACCGGTTTGGCGTGGGCTGCGAGCACACCTGCTCCTGCAGAAATGGGGGCCTGTGC       CACGCCAGCAAGCGGCAGCTGCTCCTGTGGCCTGGGCTGGACGGGGCGGCACTGCGAGCTGGCCTGTC       CCCCTGGGCGCTACGGAGCCGCCTGCCATCTGGAGTGCTCCTGCCACAACAACAGCACGTG TGA   GCCT           GCCACGGGCACCTGCCGCTGCGGCCCCGGCTTCTATGGCCAGGCCTGCGAGCACCCCTGTCCCCCTGG           CTTCCACGGGGCTGGCTGCCAGGGGTTGTGCTGGTGTCAACATGGAGCCCCCTGCGACCCCATCAGTG           GCCGATGCCTCTGCCCTGCCGGCTTCCACGGCCACTTCTGTGAGAGGGGGTGTGAGCCAGGTTCATTT           GGAGAGGGCTGCCACCAGCGCTGTGACTGTGACGGGGGGGCACCCTGTGACCCTGTCACCGGTCTCTG           CCTTTGCCCACCAGGGCGCTCAGGAGCCACCTGTAACCTGGATTGCAGAAGGGGCCAGTTTGGGCCCA           GCTGCACCCTGCACTGTGACTGCGGGGGTGGGGCTGACTGCGACCCTGTCAGTGGGCAGTGTCACTGT           GTGGATGGCTACATGGGGCCCACGTGCCGGGAAGGTGGGCCCCTCCGGCTCCCCGAGAACCCGTCCTT           AGCCCAGGGCTCAGCGGGCACACTGCCCGCCTCCAGCAGACCCACATCCCGGAGCGGTGGACCAGCGA           GGCACTAGTAGAGGCAGTCCCGTGGAGCCCGCCTCTCCAGTCCCAGCCAGAGGGGACCCTGGCCTTTG           GTGACCACTGAGAAGGACACTTCACGGGCCCAGAGCTCCTGGTACTGCCCTTCCTTTGAGGGCCGTGG           AGGGCTGTGGACAGCCCAGCAACCTGTCGCTCTTGGAGGCTGGTGTGGCCTTGAGGAGGGAAGCCTCG           CATGGCCGCTGQAAGAGAGGCGCCTCCTGGCCTGGCTCTGCAGAACCCAGGGGCACGCTCTGGGCCTG           GGCTGAGGAAGTCCCGCTCTCCCCGCGGCTCTGAGTTGGACTGAGGACAGGTGTGGGCGCCAGTGTGG           GTGCAGGCGCAGGTGCAGGCACAGGGCCACTGTCCTCCAGGCAGGCTTTTTGGTGCTAGGCCCTGGGA           CTGGAAGTCGCCCAGCCCGTATTTATGTAAAGGTATTTATGGGCCACTGCACATGCCCGCTGCAGCCC           TGGGATCAGCTGGAAGCTGCCTGTCATCTCCTGCCCAATCCCCAGAAACCCTGATTCAGGTCTGCAGG           CTCCTGCGGGCTCACCAGGCTGCTGGCTCCGGTACCATGTAAACCTAGGAAGGTAAAGGAGCAGGCAA           CCTCCTCGTGGCCTGTGTGTTTGCTGTGTTACGTGGACTCTGTGTGGGCTCCTCCCTGGGGCCCGGCC           AGCATAACGGTGCACCCAGGGACCTCCCAGTGCACCCGGGGCCCTTTGCAGGGGTGGGGGTGCCACAC           AAGTGAAGAAGTTGGGACTCATCTCAGTTCCCAGTGCTATTGAGGAGAACGCTGGGGCTGCATTCATT           ACCGCTGAGACCCAGAGACTGGCTGTTCCCAGAGAATGGCCCAGGGGGAGGAGGGCTGGTGTGGAGGC           GCAACCTGGACTGAGGCCGAACTCCCTTGGGCTCACCCCACCCACCCCTACCTGAGCATCAGCAGTGG           GGGGAGGGCAGCATCGCAGGGGCAGGGACTCCCTGGGTGAGGACAGACCAGCCCTCCCGAGCACCTGG           CACTCATGGGCTGAGGCTGACTTCTCCTGGAAGAAGGGCCCAGAGTGGAAGGAAGAGGCAGAGGGTAG           AGGTGGTGGCTGGGGGCTCCTCTGCAGAGTGGGGTGGCCAATGGAGAGGGCTGCACTCACACCGCAAC           ATAGGACTCTCTCTCCCTTAAGAAGGCCCCCTTAGGGTCTGGGCTGCCGCCCCCATCACCCTAAAACC           AGCCAAGGTAGCTGAGGCCCCAGGGCAGACAATTTCACCAGCAGGANGAGGAGGAGTCCAGTGAGCTT           GGTTGCTCACAGACAGCAAGGGAGCTGTCACAGAGGAAGCTGATGAATGGACCGCTGTGGGGAGACTT           TAAAGTAGAACAGTGATAAGGGAGGGCAGGATGGTGGGGATGCAGAAGCAGCAGCCAGAGAGAGACGC           ACTGGGGTGCAGACGGAGTGTGGAAAACGCATACCTTGAAATGAAGCATCCAGCAGATGGGGTGAGTC           GATACAGCTCAGGAGATTCTCCCAGGAATAGCAGGGAGGCGTAAAGAGAGACAACGTACAGAGATAGA           TGAATGGAAATGGGTAAGGGAGGTGTTCATTCACATCCATCTAACTGCAAAATACAAAAGTAAGAAGT           CATTGACATGAAGCAACGACGACCAAGACGTTCTCAGATCTAAAGGTGAATGATCTCAGTCAGCCTGG           AAATGCACAAGGTGGAAAAATAACATAAAAAAGCCATAAGACCTTGAAGAACATCAATGTCAAAGATA           AATTCTAAAGTCCCAGAGAAAAAAGAATGGGAATCAAATTGACCTCAGACTATACGTGAGAAACACGG           AGAGCCAGAAAACTGTGATGTTCCATCCTCAGAGTTTGAAGGAAATATTTGAAGGCTGAATTTTACAT           CCAGCTAAACTATCAAAGGCATGCAAAGTCCATGTTATTCTTAGGCCTTCAAGGCCTCGGCCATTTTT           CTACAGAAAAGCCTGATTTTAAAATGCTCTTAGAGACGTTCTCCAGCCAGAAGAGAAAGAAGCCAGGA           GGGTGCTCTGAGATATTCAGTCACCACAGTTCCCAAATGGCCTAGGAATTCAGAGAGTCAGAATATCA           CCATTACTCCCCAATGGGAACCCCCGACAGTCTCAGCATGGTGTGAGGGTGTGGACGGGGGGCCTGGC           AGGTACCAATCACTCATCCCGCTCAGTGAAGACACAGTGTTCAGCTACGGAAGCCATAAGGCAGGCCG           AGCTTCTGCCCATCCGGAGGAAATCTCAGCTATCCAACGGCGGTCAGGAGCAGAGGAAAATAAAGCAG           AATAACTAGAAAACACGCTCACAGATCCTAATGTTAACGGTTACAAATGACGACGGAAAAACAAACTC           CTGACCATATATTATATAGTTTCAAGCAGCAAGAAGGAGGATATTGAACATTCTCAACACACATAATA           AACGCTTGAGATGATGATATGCTCATTACCCTGATTTGATCACTAGACATACCATGTATCAAAACATC           ACTGTGTATCCGATGAATATCTACAATTATTGTCAATTAAAAACATCATTAAAAACAA                                           NOV37k, CG56449-06                       Protein Sequence   SEQ ID NO: 878   1403 aa   MW at 147829.8kD                     MPMGHSDRWSWRLLRLALPLPVWLPAGGGRGADSPCLCSRPHVCAEQELTLVGRRQPCVQALSHTVPV           WKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEGCLSDVGECANANGGCAGR       CRDTVGGFYCRWPPPSHQLQGDGETCQDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCA       INSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGIARCEC       HVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEAI       NGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSAD       GCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHI       AVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDC       PEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKK       CNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFR       GERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSC       GGAPCHGVTGQCRCPPGRTGEDCEAGECEGLWGLGCQEICPACHNAARCDPETGACLCLPGFVGSRCQ       DCEAGWYGPSCQTMCSCANDGHCHQDTGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCD       AISGLCLCEAGYVGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAG       FFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQC       HSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPHCEGRCACRWGGPCHLATGACLCPPG       WRGPHLSAACLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQC       PGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDC       NLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLC       HASKRQLLLWPGLDGAALAAGLSPWALRSRLPSGVLLPQQQHV                                     NOV37i, CG56449-07   SEQ ID NO: 879   4783 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 3595                       ATG CCCATGGGACATTCTGACAGGTGGTCTTGGCGTCTCCTGAGGCTGGCACTGCCACTCCCAGTCTG           GTTGCCGGCTGGGGGTGGCCGAGGCGCTGACTCTCCATGTCTCTGTTCCAGGCCCCACGTGTGTGCTG       AGCAGGAGCTGACCCTGGTGGGCCGCCGCCAGCCGTGCGTGCAGGCCTTAAGCCACACGGTGCCGGTG       TGGAAGGCCGGCTGTGGGTGGCAGGCGTGGTGCGTGGGTCATGAGCGGAGAACCGTCTACTACATGGG       CTACAGGCAGGTGTATACCACGGAGGCCCGGACCGTGCTCAGGTGCTGCCGAGGGTGGACGCAGCAGC       CCGACGAGGAGGGCTGCCTCTCGGCTGAATGCAGCGCCAGCCTCTGTTTTCACGGTGGCCGTTGTGTG       CCAGGCTCAGCCCAGCCGTGTCACTGTCCCCCCGGCTTCCAGGGACCCCGCTGTCAGTATGATGTGGA       CGAATGCCGAACCCACAACGGTGGCTGCCAGCACCGGTGCGTGAACACCCCAGGCTCCTACCTCTGTG       AGTGCAAGCCCGGCTTCCGGCTCCACACTGACAGCAGGACCTGCCTGGCCATTAACTCCTGCGCCCTG       GGCAATGGCGGCTGCCAGCACCACTGTGTCCAGCTCACAATCACTCGGCATCGCTGCCAGTGCCGGCC       CGGGTTCCAGCTCCAGGAGGACGGCAGGCATTGTGTCCGTAGAAGCCCGTGTGCCAACAGGAACGGCA       GCTGCATGCACAGGTGCCAGGTGGTCCGGGGCCTCGCCCGCTGTGAGTGCCACGTGGGCTATCAGCTA       GCAGCGGACGGCAAGGCCTGTGAAGATGTGGACGAATGTGCCGCAGGGCTGGCCCAGTGTGCCCATGG       CTGCCTCAACACCCAGGGGTCCTTCAAGTGCGTGTGTCACGCGGGCTATGAGCTGGGCGCCGATGGCC       GGCAGTGCTACCGTATTGAGATGGAAATCGTGAACAGCTGTGAGGCCAACAACGGCGGCTGCTCCCAT       GGCTGCAGCCACACCAGTGCTGGGCCCCTGTGCACCTGTCCCCGCGGCTACGAGCTGGACACAGATCA       GAGGACCTGCATCAGATGTCGACGACTGTGCAGACAGCCCGTGCTGCAGCAGGTGTGCACCAACAACC       CTGGCGGGTACGAGTGCGGCTGCTACGCCGGCTACCGGCTCAGTGCCGATGGCTGCGGCTGCGAGGAT       GTGGATGAGTGCGCCTCCAGCCGTGGCGGCTGCGAGCACCACTGCACCAACCTGGCCGGCTCCTTCCA       GTGCTCCTGCGAGGCCGGCTACCGGCTGCACGAGGACCGTAGGGGCTGCAGCGCCCTGGAGGAGCCGA       TGGTGGACCTGGACGGCGAGCTGCCTTTCGTGCGGCCCCTGCCCCACATTGCCGTGCTCCAGGACGAG       CTGCCGCAACTCTTCCAGGATGACGACGTCGGGGCCGATGAGGAAGAGGCAGAGTTGCGGGGCGAACA       CACGCTCACAGAGAAGTTTGTCTGCCTGGATGACTCCTTTGGCCATGACTGCAGCTTGACCTGTGATG       ACTGCAGGAACGGAGGGACCTGCCTCCTGGGCCTGGATGGCTGTGATTGCCCCGAGGGCTGGACTGGG       CTCATCTGCAATGAGAGTTGTCCTCCGGACACCTTTGGGAAGAACTGCAGCTTCTCCTGCAGCTGTCA       GAATGGTGGGACCTGCGACTCTGTCACGGGGGCCTGCCGCTGCCCCCCGGGTGTCAGTGGAACTAACT       GTGAGGATGGCTGCCCCAAGGGCTACTATGGCAAGCACTGTCGCAAGAAATGCAACTGTGCCAACCGG       GGCCGGTGCCACCGCCTCTACGGGGCCTGCCTCTGCGACCCAGGGCTCTACGGCCGCTTCTGCCACCT       CGCCTGCCCGCCGTGGGCCTTTGGGCCGGGCTGCTCGGAGGAGTGCCAGTGTGTGCAGCCCCACACGC       AGTCCTGTGACAAGAGGGATGGCAGCTGCTCCTGCAAGGCTGGCTTCCGGGGCGAGCGCTGTCAGGCA       GAGTGTGAGCTGGGCTACTTTGGGCCGGGGTGCTGGCAGGCATGCACCTGCCCAGTGGGCGTGGCCTG       TGACTCCGTGAGCGGCGAGTGTGGGAAGCGGTGTCCTGCTGGCTTCCAGGGAGAGGACTGTGGCCAAG       AGTGCCCGGTGGGGACGTTTGGCGTGAACTGCTCGAGCTCCTGCTCCTGTGGGGGGGCCCCCTGCCAC       GGGGTCACGGGGCAGTGCCGGTGTCCACCGGGGAGGACTGGGGAAGACTGTGAGGCAGATTGTCCCGA       GGGCCGCTGGGGGCTGGGCTGCCAGGAGATCTGCCCAGCATGCCAGCACGCTGCCCGCTGCGACCCTG       AGACCGGAGCCTGCCTGTGCCTCCCTGGCTTCGTCGGCAGCCGCTGCCAGGACGTGTGCCCAGCAGGC       TGGTATGGTCCCAGCTGCCAGACAAGGTGCTCTTGTGCCAATGATGGGCACTGCCACCCAGCCACCGG       ACACTGCAGCTGTGCCCCCGGGTGGACCGGCTTTAGCTGCCAGAGAGCCTGTGATACTGGGCACTGGG       GACCTGACTGCAGCCACCCCTGCAACTGCAGCGCTGGCCACGGGAGCTGTGATGCCATCAGCGGCCTG       TGTCTGTGTGAGGCTGGCTACGTGGGCCCGCGGTGCGAGCAGCAGTGTCCCCAGGGCCACTTTGGGCC       CGGCTGTGAGCAGCTGTGCCAGTGTCAGCATGGAGCAGCCTGTGACCACGTCAGCGGGGCCTGCACCT       GCCCGGCCGGCTGGAGGGGCACCTTCTGCGAGCATGCCTGCCCGGCCGGCTTCTTTGGATTGGACTGT       CGTAGTGCCTGCAACTGCACCGCCGGAGCTGCCTGTGATGCCGTGAATGGCTCCTGCCTCTGCCCCGC       TGGCCGCCGGGGCCCCCGCTGTGCCGAGACCTGCCCTGCCGGCCTGTACGGCGACAACTGTCGGCATT       CCTGCCTCTGCCAGAACGGAGGGACCTGTGACCCTGTCTCAGGCCACTGTGCGTGCCCAGAGGGCTGG       GCCGGCCTGGCCTGTGAGAAGGAGTGCCCCCCCCGGGACGTCAGAGCTGGCTGCCGGCACAGCGGCGG       TTGCCTCAACGGGGGCCTGTGTGACCCGCACACGGGCCGCTGCCTCTGCCCAGCCGGCTGGACTGGGG       ACAAGTGTCAGAGCCATCCCCACGGGCCCCTCCTAGAAGCCTCCGCAGCCCTCATCTTTCTGCAGCCT       GCCTGCGGGGCTGGTTTGGAGAGGCCTGTGCCCAGCGCTGCAGCTGCCCGCCTGCCGCTGCCTGCCAC       CACGTCACTGGGGCCTGCCGCTGTCCCCCTGGCTTCACTGGCTCCGGCTGCGAGCAGGGATGTCCGCC       CGGGCGGTATGGGCCAGGCTGTGAACAGCTGTGTGGGTGTCTCAACGGGGGCTCCTGTGATGCGGCCA       CGGGGGCCTGCCGCTGCCCCACTGGGTTCCTCGGGACGGACTGCAACCTCACCTGTCCGCAGGGCCGC       TTCGGCCCCAACTGCACCCACGTGTGTGGTTGTGGGCAGGGGGCGGCCTGCGACCCTG TGA   CCGGCAC           CTGCCTCTGCCCCCCGGGGAGAGCCGGCGTCCGCTGTGAGCGAGGCTGCCCCCAGAACCGGTTTGGCG           TGGGCTGCGAGCACACCTGCTCCTCCAGAAATGGGGGCCTGTGCCACGCCAGCAACGGCAGCTGCTCC           TGTGGCCTGGGCTGGACGGGGCGGCACTGCGAGCTGGCCTGTCCCCCTGGGCGCTACGGAGCCGCCTG           CCATCTGGAGTGCTCCTGCCACAACAACAGCACGGGTGAGCCTGCCACGGGCACCTGCCGCTGCGGCC           CCGGCTTCTATGGCCAGGCCTGCGAGCACCCCTGTCCCCCTGGCTTCCACGGGGCTGGCTGCCAGGGG           TTGTGCTGGTGTCAACATGGAGCCCCCTGCGACCCCATCAGTGGCCGATGCCTCTGCCCTGCCGGCTT           CCACGGCCACTTCTGTGAGAGGGGGTGTGAGCCAGGTTCATTTGGAGAGGGCTGCCACCAGCGCTGTG           ACTGTGACGGGGGGGCACCCTGTGACCCTGTCACCGGTCTCTGCCTTTGCCCACCAGGGCGCTCAGGA           GCCACCTGTAACCTGGATTGCAGAAGGGGCCAGTTTGGGCCCAGCTGCACCCTGCACTGTGACTGCGG           GGGTGGGGCTGACTGCGACCCTGTCAGTGGGCAGTGTCACTGTGTGGATGGCTACATGGGGCCCACGT           GCCGGGAAGGTGGGCCCCTCCGGCTCCCCGAGAACCCGTCCTTAGCCCAGGGCTCAGCGGGCACACTC           CCCGCCTCCAGCAGACCCACATCCCGGAGCGGTGGACCAGCGAGGCACTAGTAGAGGCAGTCCCGTGG           AGCCCGCCTCTCCAGTCCCAGCCAGAGGGGACCCTGGCCTTTGGTGACCACTGAGAAGGACACTTCAC           GGGCCCAGAGCTCCTGGTACTGCCCTTCCTTTGAGGGCCGTGGAGGGCTGTGGACAGCCCAGCAACCT           GTCGCTCTTGGAGGCTGGTGTGGCCTTGAGGAGGGAAGCCTCGCATGGCCGCTGGAAGAGAGGCGCCT           CCTGGCCTGGCTCTGCAGAACCCAGGGGCACGCTCTGGGCCTGGGCTGAGGAAGTCCCGCTCTCCCCG           CGGCTCTGAGTTGGACTGAGGACAGGTGTGGGCGCCAGTGTGGGTGCAGGCGCAGGTGCAGGCACAGC           GCCACTGTCCTCCAGGCAGGCTT                                           NOV371, CG56449-07                       Protein Sequence   SEQ ID NO: 880   1198 aa   MW at 126170.7kD                     MPMGHSDRWSWRLLRLALPLPVWLPAGGGRGADSPCLCSRPHVCAEQELTLVGRRQPCVQALSHTVPV           WKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWTQQPDEEGCLSAECSASLCFHGGRCV       PGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCAL       GNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANPNGSCMHRCQVVRGLARCECHVGYQL       AADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSH       GCSHTSAGPLCTCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCED       VDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHIAVLQDE       LPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTG       LICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANR       GRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQA       ECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCH       GVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAG       WYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGL       CLCEAGYVGPRCEQQCPQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDC       RSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGW       AGLACEKECPPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSHPHGPLLEASAALIFLQP       ACGAGLERPVPSAAAARLPLPATTSLGPAAVPLASLAPAASRDVRPGGMGQAVNSCVGVSTGAPVMRP       RGPAAAPLGSSGRTATSPVRRAASAPTAPTCVVVGRGRPATL                                     NOV37m, CG56449-08   SEQ ID NO: 881   4835 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAG at 4732                       ATG TCGTTCCTTGAAGAGGCGAGGGCAGCGGGGCGCGCGGTGGTCCTGGCGTTGGTGCTGCTGCTGCT           CCCCGCCGTGCCCGTGGGCGCCAGCGTTCCGCCGCGGCCCCTGCTCCCGCTGCAGCCCGGCATGCCCC       ACGTGTGTGCTGAGCAGGAGCTGACCCTGGTGGGCCGCCGCCAGCCGTGCGTGCAGGCCTTAAGCCAC       ACGGTGCCGGTGTGGAAGGCCGGCTGTGGGTGGCAGGCGTGGTGCGTGGGTCATGAGCGGAGGACCGT       CTACTACATGGGCTACAGGCAGGTGTATACCACGGAGGCCCGGACCGTGCTCAGGTGCTGCCGAGGGT       GGATGCAGCAGCCCGACGAGGAGGGCTGCCTCTCGGATGTGGGTGAGTGTGCCAACGCCAACGGGGGC       TGTGCGGGTCGGTGCCGGGACACCGTGGGGGGCTTCTACTGCCGCTGGCCCCCCCCCAGCCACCAGCT       GCAGGGTGATGGCGAGACTTGCCAAGATGTGGACGAATGCCGAACCCACAACGGTGGCTGCCAGCACC       GGTGCGTGAACACCCCAGGCTCCTACCTCTGTGAGTGCAAGCCCGGCTTCCGGCTCCACACTGACAGC       AGGACCTGCGCCATTAACTCCTGCGCCCTGGGCAATGGCGGCTGCCAGCACCACTGTGTCCAGCTCAC       AATCACTCGGCATCGCTGCCAGTGCCGGCCCGGGTTCCAGCTCCAGGAGGACGGCAGGCATTGTGTCC       GTAGAAGCCCGTGTGCCAACAGGAACGGCAGCTGCATGCACAGGTGCCAGGTGGTCCGGGGCCTCGCC       CGCTGTGAGTGCCACGTGGGCTATCAGCTAGCAGCGGACGGCAAGGCCTGTGAAGATGTGGACGAATG       TGCCGCAGGGCTGGCCCAGTGTGCCCATGGCTGCCTCAACACCCAGGGGTCCTTCAAGTGCGTGTGTC       ACGCGGGCTATGAGCTGGGCGCCGATGGCCGGCAGTGCTACCGTATTGAGATGGAAATCGTGAACAGC       TGTGAGGCCAACAACGGCGGCTGCTCCCATGGCTGCAGCCACACCAGTGCTGGGCCCCTGTGCACCTG       TCCCCGCGGCTACGAGCTGGACACAGATCAGAGGACCTGCATCAGATGTCGACGACTGTGCAGACAGC       CCGTGCTGCAGCAGGTGTGCACCAACAACCCTGGCGGGTACGAGTGCGGCTGCTACGCCGGCTACCGG       CTCAGTGCCGATGGCTGCGGCTGCGAGGATGTGGATGAGTGCGCCTCCAGCCGTGGCGGCTGCGAGCA       CCACTGCACCAACCTGGCCGGCTCCTTCCAGTGCTCCTGCGAGGCCGGCTACCGGCTGCACGAGGACC       GTAGGGGCTGCAGCGCCCTGGAGGAGCCGATGGTGGACCTGGACGGCGAGCTGCCTTTCGTGCGGCCC       CTGCCCCACATTGCCGTGCTCCAGGACGAGCTGCCGCAACTCTTCCAGGATGACGACGTCGGGGCCGA       TGAGGAAGAGGCAGAGTTGCGGGGCGAACACACGCTCACAGAGAAGTTTGTCTGCCTGGATGACTCCT       TTGGCCATGACTGCAGCTTGACCTGTGATGACTGCAGGAACGGAGGGACCTGCCTCCTGGGCCTGGAT       GGCTGTGATTGCCCCGAGGGCTGGACTGGGCTCATCTGCAATGAGAGTTGTCCTCCGGACACCTTTGG       GAAGAACTGCAGCTTCTCCTGCAGCTGTCAGAATGGTGGGACCTGCGACTCTGTCACGGGGGCCTGCC       GCTGCCCCCCGGGTGTCAGTGGAACTAACTGTGAGGATGGCTGCCCCAAGGGCTACTATGGCAAGCAC       TGTCGCAAGAAATGCAACTGTGCCAACCGGGGCCGGTGCCACCGCCTCTACGGGGCCTGCCTCTGCGA       CCCAGGGCTCTACGGCCGCTTCTGCCACCTCGCCTGCCCGCCGTGGGCCTTTGGGCCGGGCTGCTCGG       AGGAGTGCCAGTGTGTGCAGCCCCACACGCAGTCCTGTGACAAGAGGGATGGCAGCTGCTCCTGCAAG       GCTGGCTTCCGGGGCGAGCGCTGTCAGGCAGAGTGTGAGCCGGGCTACTTTGGGCCGGGGTGCTGGCA       GGCATGCACCTGCCCAGTGGGCGTGGCCTGTGACTCCGTGAGCGGCGAGTGTGGGAAGCGGTGTCCTG       CTGGCTTCCAGGGAGAGGACTGTGGCCAAGAGTGCCCGGTGGGGACCTTTGGCGTGAACTGCTCGAGC       TCCTGCTCCTGTGGGGGGGCCCCCTGCCACGGGGTCACGGGGCAGTGCCGGTGTCCGCCGGGGAGGAC       TGGGGAAGACTGTGAGGCAGGTGAGTGTGAGGGCCTCTGGGGGCTGGGCTGCCAGGAGATCTGCCCAG       CATGCCATAACGCTGCTCGCTGCGACCCTGAGACCGGAGCCTGCCTGTGCCTCCCTGGCTTTGTCGGC       AGCCGCTGCCAGGACTGTGAGGCAGGCTGGTATGGTCCCAGCTGCCAGACAATGTGCTCTTGTGCCAA       TGATGGGCACTGCCACCAAGACACGGGACACTGCAGCTGTGCCCCCGGGTGGACCGGCTTTAGCTGCC       AGAGAGCCTGTGATACTGGGCACTGGGGACCTGACTGCAGCCACCCCTGCAACTGCAGCGCTGGCCAC       GGGAGCTGTGATGCCATCAGCGGCCTGTGTCTGTGTGAGGCTGGCTACGTGGGCCCGCGGTGCGAGCA       GTCAGAGTGTCCCCAGGGCCACTTTGGGCCCGGCTGTGAGCAGCGGTGCCAGTGTCAGCATGGAGCAG       CCTGTGACCACGTCAGCGGGGCCTGCACCTGCCCGGCCGGCTGGAGGGGCACCTTCTGCGAGCATGCC       TGCCCGGCCGGCTTCTTTGGATTGGACTGTCGCAGTGCCTGCAACTGCACCGCCGGAGCTGCCTGTGA       TGCCGTGAATGGCTCCTGCCTCTGCCCCGCTGGCCGCCGGGGCCCCCGCTGTGCCGAGAGTGCCTGCC       CAGCCCACACCTACGGGCACAATTGCAGCCAGGCCTGTGCCTGCTTTAACGGGGCCTCCTGTGACCCT       GTCCACGGGCAGTGCCACTGTGCCCCTGGCTGGATGGGGCCCTCCTGCCTGCAGGCCTGCCCTGCCGG       CCTGTACGGCGACAACTGTCGGCATTCCTGCCTCTGCCAGAACGGAGGGACCTGTGACCCTGTCTCAG       GCCACTGTGCGTGCCCAGAGGGCTGGGCCGGCCTGGCCTGTGAGGTAGAGTGCCTCCCCCGGGACGTC       AGAGCTGGCTGCCGGCACAGCGGCGGTTGCCTCAACGGGGGCCTGTGTGACCCGCACACGGGCCGCTG       CCTCTGCCCAGCCGGCTGGACTGGGGACAAGTGTCAGAGCCCTGCAGCCTGTGCCAAGGGCACATTCG       GGCCTCACTGTGAGGGGCGCTGTGCCTGCCGGTGGGGAGGCCCCTGCCACCTTGCCACCGGGGCCTGC       CTCTGCCCTCCGGGGTGGCGGGGGCCTCATCTTTCTGCAGCCTGCCTGCGGGGCTGGTTTGGAGAGGC       CTGTGCCCAGCGCTGCAGCTGCCCGCCTGGCGCTGCCTGCCACCACGTCACTGGGGCCTGCCGCTGTC       CCCCTGGCTTCACTGGCTCCGGCTGCGAGCAGGCCTGCCCACCCGGCAGCTTTGGGGAGGACTGTGCG       CAGATGTGCCAGTGTCCCGGTGAGAACCCGGCCTGCCACCCTGCCACCGGGACCTGCTCATGTGCTGC       TGGCTACCACGGCCCCAGCTGCCAGCAACGATGTCCGCCCGGGCGGTATGGGCCAGGCTGTGAACAGC       TGTGTGGGTGTCTCAACGGGGGCTCCTGTGATGCGGCCACGGGGGCCTGCCGCTGCCCCACTGGGTTC       CTCGGGACGGACTGCAACCTCACCTGTCCGCAGGGCCGCTTCGGCCCCAACTGCACCCACGTGTGTGG       GTGTGGGCAGGGGGCGGCCTGCGACCCTGTGACCGGCACCTGCCTCTGCCCCCCGGGGAGAGCCGGCG       TCCGCTGTGAGCGAGGCTGCCCCCAGAACCGGTTTGGCGTGGGCTGCGAGCACACCTGCTCCTGCAGA       AATGGGGGCCTGTGCCACGCCAGCAACGGCAGCTGCTCCTGTGGCCTGGGCTGGACGGGGCGGCACTG       CGAGCTGGCCTGTCCCCCTGGGCGCTACGGAGCCGCCTGCCATCTGGAGTGCTCCTGCCACAACAACA       GCACGTGTGAGCCTGCCACGGGCACCTGCCGCTGCGGCCCCGGCTTCTATGGCCAGGCCTGCGAGCAC       CCCTGTCCCCCTGGCTTCCACGGGGCTGGCTGCCAGGGGTTGTGCTGGTGTCAACATGGAGCCCCCTG       CGACCCCATCAGTGGCCGATGCCTCTGCCCTGCCGGCTTCCACGGCCACTTCTGTGAGAGGGGGTGTG       AGCCAGGTTCATTTGGAGAGGGCTGCCACCAGCGCTGTGACTGTGACGGGGGGGCACCCTGTGACCCT       GTCACCGGTCTCTGCCTTTGCCCACCAGGGCGCTCAGGAGCCACCTGTAACCTGGATTGCAGAAGGGG       CCAGTTTGGGCCCAGCTGCACCCTGCACTGTGACTGCGGGGGTGGGGCTGACTGCGACCCTGTCAGTG       GGCAGTGTCACTGTGTGGATGGCTACATGGGGCCCACGTGCCGGGAAGCGGGCACACTGCCCGCCTCC       AGCAGACCCACATCCCGGAGCGGTGGACCAGCGAGGCAC TAG   TAGAGGCAGTCCCGTGGAGCCCGCCT           CTCCAGTCCCAGCCAGAGGGGACCCTGGCCTTTGGTGACCACTGAGAAGGACACTTCACGGGCCCAGA           GCTCCTG                                           NOV37m, CG56449-08                       Protein Sequence   SEQ ID NO: 882   1577 aa   MW at 164962.6kD                     MSFLEEARAAGRAVVLALVLLLLPAVPVGASVPPRPLLPLQPGMPHVCAEQELTLVGRRQPCVQALSH           TVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEGCLSDVGECANANGG       CAGRCRDTVGGFYCRWPPPSHQLQGDGETCQDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDS       RTCAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLA       RCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNS       CEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYR       LSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRP       LPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLD       GCDCPEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKH       CRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCK       AGFRGERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSS       SCSCGGAPCHGVTGQCRCPPGRTGEDCEAGECEGLWGLGCQEICPACHNAARCDPETGACLCLPGFVG       SRCQDCEAGWYGPSCQTMCSCANDGHCHQDTGHCSCAPGWTGFSCQAACDTGHWGPDCSHPCNCSAGH       GSCDAISGLCLCEAGYVGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHA       CPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAESACPAHTYGHNCSQACACFNGASCDP       JHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEVECLPRDV       RAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPHCEGRCACRWGGPCHLATGAC       LCPPGWRGPHLSAACLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCA       QMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGF       LGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCR       NGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEH       PCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDP       VTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREAGTLPAS       SRPTSRSGGPARH                                     NOV37n, CG56449-10   SEQ ID NO: 883   5000 bp           DNA Sequence   ORF Start: ATG at 169   ORF Stop: at 4900                       TGCTGTTACAGGTGGAGGGCAGTGTAGTCTGAGCAGTACTCGTTGCTGCCGCGCGCGCCACCAGACAT               AATAGCTGACAGACTAACAGACTGTTCCTTTCCATGGGTCTTTTCTGCAGTCACCGTCCTTGACACGA           AGCTTTCTAGAAGATCTTCGCGAGGATCCACC   ATG TCGTTCCTTGAAGAGGCGAGGGCAGCGGGGCGC       GCGGTGGTCCTGGCGTTGGTGCTGCTGCTGCTCCCCGCCGTGCCCGTGGGCGCCAGCGTTCCGCCGCG       GCCCCTGCTCCCGCTGCAGCCCGGCATGCCCCACGTGTGTGCTGAGCAGGAGCTGACCCTGGTGGGCC       GCCGCCAGCCGTGCGTGCAGGCCTTAAGCCACACGGTGCCGGTGTGGAAGGCCGGCTGTGGGTGGCAG       GCGTGGTGCGTGGGTCATGAGCGGAGGACCGTCTACTACATGGGCTACAGGCAGGTGTATACCACGGA       aGGCCCGACCGTGCTCAGGTGCTGCCGAGGGTGGATGCAGCAGCCCGACGAGGAGGGCTGCCTCTCGG       ATGTGGGTGAGTGTGCCAACGCCAACGGGGGCTGTGCGGGTCGGTGCCGGGACACCGTGGGGGGCTTC       TACTGCCGCTGGCCCCCCCCCAGCCACCAGCTGCAGGGTGATGGCGAGACTTGCCAAGATGTGGACGA       ATGCCGAACCCACAACGGTGGCTGCCAGCACCGGTGCGTGAACACCCCAGGCTCCTACCTCTGTGAGT       GCAAGCCCGGCTTCCGGCTCCACACTGACAGCAGGACCTGCGCCATTAACTCCTGCGCCCTGGGCAAT       GGCGGCTGCCAGCACCACTGTGTCCAGCTCACAATCACTCGGCATCGCTGCCAGTGCCGGCCCGGGTT       CCAGCTCCAGGAGGACGGCAGGCATTGTGTCCGTAGAAGCCCGTGTGCCAACAGGAACGGCAGCTGCA       TGCACAGGTGCCAGGTGGTCCGGGGCCTCGCCCGCTGTGAGTGCCACGTGGGCTATCAGCTAGCAGCG       GACGGCAAGGCCTGTGAAGATGTGGACGAATGTGCCGCAGGGCTGGCCCAGTGTGCCCATGGCTGCCT       CAACACCCAGGGGTCCTTCAAGTGCGTGTGTCACGCGGGCTATGAGCTGGGCGCCGATGGCCGGCAGT       GCTACCGTATTGAGATGGAAATCGTGAACAGCTGTGAGGCCAACAACGGCGGCTGCTCCCATGGCTGC       AGCCACACCAGTGCTGGGCCCCTGTGCACCTGTCCCCGCGGCTACGAGCTGGACACAGATCAGAGGAC       CTGCATCAGATGTCGACGACTGTGCAGACAGCCCGTGCTGCAGCAGGTGTGCACCAACAACCCTGGCG       GGTACGAGTGCGGCTGCTACGCCGGCTACCGGCTCAGTGCCGATGGCTGCGGCTGCGAGGATGTGGAT       GAGTGCGCCTCCAGCCGTGGCGGCTGCGAGCACCACTGCACCAACCTGGCCGGCTCCTTCCAGTGCTC       CTGCGAGGCCGGCTACCGGCTGCACGAGGACCGTAGGGGCTGCAGCGCCCTGGAGGAGCCGATGGTGG       ACCTGGACGGCGAGCTGCCTTTCGTGCGGCCCCTGCCCCACATTGCCGTGCTCCAGGACGAGCTGCCG       CAACTCTTCCAGGATGACGACGTCGGGGCCGATGAGGAAGAGGCAGAGTTGCGGGGCGAACACACGCT       CACAGAGAAGTTTGTCTGCCTGGATGACTCCTTTGGCCATGACTGCAGCTTGACCTGTGATGACTGCA       GGAACGGAGGGACCTGCCTCCTGGGCCTGGATGGCTGTGATTGCCCCGAGGGCTGGACTGGGCTCATC       TGCAATGAGAGTTGTCCTCCGGACACCTTTGGGAAGAACTGCAGCTTCTCCTGCAGCTGTCAGAATGG       TGGGACCTGCGACTCTGTCACGGGGGCCTGCCGCTGCCCCCCGGGTGTCAGTGGAACTAACTGTGAGG       ATGGCTGCCCCAAGGGCTACTATGGCAAGCACTGTCGCAAGAAATGCAACTGTGCCAACCGGGGCCGG       TGCCACCGCCTCTACGGGGCCTGCCTCTGCGACCCAGGGCTCTACGGCCGCTTCTGCCACCTCGCCTG       CCCGCCGTGGGCCTTTGGGCCGGGCTGCTCGGAGGAGTGCCAGTGTGTGCAGCCCCACACGCAGTCCT       GTGACAAGAGGGATGGCAGCTGCTCCTGCAAGGCTGGCTTCCGGGGCGAGCGCTGTCAGGCAGAGTGT       GAGCCGGGCTACTTTGGGCCGGGGTGCTGGCAGGCATGCACCTGCCCAGTGGGCGTGGCCTGTGACTC       CGTGAGCGGCGAGTGTGGGAAGCGGTGTCCTGCTGGCTTCCAGGGAGAGGACTGTGGCCAAGAGTGCC       CGGTGGGGACCTTTGGCGTGAACTGCTCGAGCTCCTGCTCCTGTGGGGGGGCCCCCTGCCACGGGGTC       ACGGGGCAGTGCCGGTGTCCGCCGGGGAGGACTGGGGAAGACTGTGAGGCAGGTGAGTGTGAGGGCCT       CTGGGGGCTGGGCTGCCAGGAGATCTGCCCAGCATGCCATAACGCTGCTCGCTGCGACCCTGAGACCG       GAGCCTGCCTGTGCCTCCCTGGCTTTGTCGGCAGCCGCTGCCAGGACTGTGAGGCAGGCTGGTATGGT       CCCAGCTGCCAGACAATGTGCTCTTGTGCCAATGATGGGCACTGCCACCAAGACACGGGACACTGCAG       CTGTGCCCCCGGGTGGACCGGCTTTAGCTGCCAGAGAGCCTGTGATACTGGGCACTGGGGACCTGACT       GCAGCCACCCCTGCAACTGCAGCGCTGGCCACGGGAGCTGTGATGCCATCAGCGGCCTGTGTCTGTGT       GAGGCTGGCTACGTGGGCCCGCGGTGCGAGCAGTCAGAGTGTCCCCAGGGCCACTTTGGGCCCGGCTG       TGAGCAGCGGTGCCAGTGTCAGCATGGAGCAGCCTGTGACCACGTCAGCGGGGCCTGCACCTGCCCGG       CCGGCTGGAGGGGCACCTTCTGCGAGCATGCCTGCCCGGCCGGCTTCTTTGGATTGGACTGTCGCAGT       GCCTGCAACTGCACCGCCGGAGCTGCCTGTGATGCCGTGAATGGCTCCTGCCTCTGCCCCGCTGGCCG       CCGGGGCCCCCGCTGTGCCGAGAGTGCCTGCCCAGCCCACACCTACGGGCACAATTGCAGCCAGGCCT       GTGCCTGCTTTAACGGGGCCTCCTGTGACCCTGTCCACGGGCAGTGCCACTGTGCCCCTGGCTGGATG       GGGCCCTCCTGCCTGCAGGCCTGCCCTGCCGGCCTGTACGGCGACAACTGTCGGCATTCCTGCCTCTG       CCAGAACGGAGGGACCTGTGACCCTGTCTCAGGCCACTGTGCGTGCCCAGAGGGCTGGGCCGGCCTGG       CCTGTGAGGTAGAGTGCCTCCCCCGGGACGTCAGAGCTGGCTGCCGGCACAGCGGCGGTTGCCTCAAC       GGGGGCCTGTGTGACCCGCACACGGGCCGCTGCCTCTGCCCAGCCGGCTGGACTGGGGACAAGTGTCA       GAGCCCTGCAGCCTGTGCCAAGGGCACATTCGGGCCTCACTGTGAGGGGCGCTGTGCCTGCCGGTGGG       GAGGCCCCTGCCACCTTGCCACCGGGGCCTGCCTCTGCCCTCCGGGGTGGCGGGGGCCTCATCTTTCT       GCAGCCTGCCTGCGGGGCTGGTTTGGAGAGGCCTGTGCCCAGCGCTGCAGCTGCCCGCCTGGCGCTGC       CTGCCACCACGTCACTGGGGCCTGCCGCTGTCCCCCTGGCTTCACTGGCTCCGGCTGCGAGCAGGCCT       GCCCACCCGGCAGCTTTGGGGAGGACTGTGCGCAGATGTGCCAGTGTCCCGGTGAGAACCCGGCCTGC       CACCCTGCCACCGGGACCTGCTCATGTGCTGCTGGCTACCACGGCCCCAGCTGCCAGCAACGATGTCC       GCCCGGGCGGTATGGGCCAGGCTGTGAACAGCTGTGTGGGTGTCTCAACGGGGGCTCCTGTGATGCGG       CCACGGGGGCCTGCCGCTGCCCCACTGGGTTCCTCGGGACGGACTGCAACCTCACCTGTCCGCAGGGC       CGCTTCGGCCCCAACTGCACCCACGTGTGTGGGTGTGGGCAGGGGGCGGCCTGCGACCCTGTGACCGG       CACCTGCCTCTGCCCCCCGGGGAGAGCCGGCGTCCGCTGTGAGCGAGGCTGCCCCCAGAACCGGTTTG       GCGTGGGCTGCGAGCACACCTGCTCCTGCAGAAATGGGGGCCTGTGCCACGCCAGCAACGGCAGCTGC       TCCTGTGGCCTGGGCTGGACGGGGCGGCACTGCGAGCTGGCCTGTCCCCCTGGGCGCTACGGAGCCGC       CTGCCATCTGGAGTGCTCCTGCCACAACAACAGCACGTGTGAGCCTGCCACGGGCACCTGCCGCTGCG       GCCCCGGCTTCTATGGCCAGGCCTGCGAGCACCCCTGTCCCCCTGGCTTCCACGGGGCTGGCTGCCAG       GGGTTGTGCTGGTGTCAACATGGAGCCCCCTGCGACCCCATCAGTGGCCGATGCCTCTGCCCTGCCGG       CTTCCACGGCCACTTCTGTGAGAGGGGGTGTGAGCCAGGTTCATTTGGAGAGGGCTGCCACCAGCGCT       GTGACTGTGACGGGGGGGCACCCTGTGACCCTGTCACCGGTCTCTGCCTTTGCCCACCAGGGCGCTCA       GGAGCCACCTGTAACCTGGATTGCAGAAGGGGCCAGTTTGGGCCCAGCTGCACCCTGCACTGTGACTG       CGGGGGTGGGGCTGACTGCGACCCTGTCAGTGGGCAGTGTCACTGTGTGGATGGCTACATGGGGCCCA       CGTGCCGGGAAGCGGGCACACTGCCCGCCTCCAGCAGACCCACATCCCGGAGCGGTGGACCAGCGAGG       CACGTA TTCCCCGGGCTCGAGGGTAAGCCTATCCCTAACCCTCTCCTCGGTCTCGATTCTACGCGTAC           CGGTCATCACCACCATCACCATTGAGTTTAATTCAT                                           NOV37n, CG56449-10                       Protein Sequence   SEQ ID NO: 884   1577 aa   MW at 164962.6kD                     MSFLEEARAAGRAVVLALVLLLLPAVPVGASVPPRPLLPLQPGMPHVCAEQELTLVGRRQPCVQALSH           TVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEGCLSDVGECANANGG       CAGRCRDTVGGFYCRWPPPSHQLQGDGETCQDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDS       RTCAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLA       RCECHVGYQLAADGKACEDVDECAAGTAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMETVNS       CEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYR       LSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRP       LPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRIGGTCLLGLD       GCDCPEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKH       CRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCK       AGFRGERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSS       SCSCGGAPCHGVTGQCRCPPGRTGEDCEAGECEGLWGLGCQEICPACHNAARCDPETGACLCLPGFVG       GSCDAISGLCLCEAGYVGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHA       CPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAESACPAHTYGHNCSQACACFNGASCDP       VHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEVECLPRDV       RAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPHCEGRCACRWGGPCHLATGAC       LCPPGWRGPHLSAACLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCA       QMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGF       LGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGPAGVRCERGCPQNRFGVGCEHTCSCR       NGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEH       PCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDP       VTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREAGTLPAS       SRPTSRSGGPARH                                     NOV37o, CG56449-1   SEQ ID NO: 885   5005 bp           DNA Sequence   ORF Start: at 258   ORF Stop: at 4899                       AACGGGTGGAGGGCAGTGTAGTCTGAGCAGTACTCGTTGCTGCCGCGCGCGCCACCAGACATAATAGC               TGACAGACTAACAGACTGTTCCTTTCCATGGGTCTTTTCTGCAGTCACCGTCCTTGACACGAAGCTCT           AGCCACCATGGAGACAGACACACTCCTGCTATGGGTACTGCTGCTCTGGGTTCCAGGTTCCACTGGTG           ACGCGGCCCAGCCGGCCAGGCGCGCGCGCCGTACGAAGCTTTCGCGAGGATCC AGCGTTCCGCCGCGG       CCCCTGCTCCCGCTGCAGCCCGGCATGCCCCACGTGTGTGCTGAGCAGGAGCTGACCCTGGTGGGCCG       CCGCCAGCCGTGCGTGCAGGCCTTAAGCCACACGGTGCCGGTGTGGAAGGCCGGCTGTGGGTGGCAGG       CGTGGTGCGTGGGTCATGAGCGGAGGACCGTCTACTACATGGGCTACAGGCAGGTGTATACCACGGAG       GCCCGGACCGTGCTCAGGTGCTGCCGAGGGTGGATGCAGCAGCCCGACGAGGAGGGCTGCCTCTCGGA       TGTGGGTGAGTGTGCCAACGCCAACGGGGGCTGTGCGGGTCGGTGCCGGGACACCGTGGGGGGCTTCT       ACTGCCGCTGGCCCCCCCCCAGCCACCAGCTGCAGGGTGATGGCGAGACTTGCCAAGATGTGGACGAA       TGCCGAACCCACAACGGTGGCTGCCAGCACCGGTGCGTGAACACCCCAGGCTCCTACCTCTGTGAGTG       CAAGCCCGGCTTCCGGCTCCACACTGACAGCAGGACCTGCGCCATTAACTCCTGCGCCCTGGGCAATG       GCGGCTGCCAGCACCACTGTGTCCAGCTCACAATCACTCGGCATCGCTGCCAGTGCCGGCCCGGGTTC       CAGCTCCAGGAGGACGGCAGGCATTGTGTCCGTAGAAGCCCGTGTGCCAACAGGAACGGCAGCTGCAT       GCACAGGTGCCAGGTGGTCCGGGGCCTCGCCCGCTGTGAGTGCCACGTGGGCTATCAGCTAGCAGCGG       ACGGCAAGGCCTGTGAAGATGTGGACGAATGTGCCGCAGGGCTGGCCCAGTGTGCCCATGGCTGCCTC       AACACCCAGGGGTCCTTCAAGTGCGTGTGTCACGCGGGCTATGAGCTGGGCGCCGATGGCCGGCAGTG       CTACCGTATTGAGATGGAAATCGTGAACAGCTGTGAGGCCAACAACGGCGGCTGCTCCCATGGCTGCA       GCCACACCAGTGCTGGGCCCCTGTGCACCTGTCCCCGCGGCTACGAGCTGGACACAGATCAGAGGACC       TGCATCAGATGTCGACGACTGTGCAGACAGCCCGTGCTGCAGCAGGTGTGCACCAACAACCCTGGCGG       GTACGAGTGCGGCTGCTACGCCGGCTACCGGCTCAGTGCCGATGGCTGCGGCTGCGAGGATGTGGATG       AGTGCGCCTCCAGCCGTGGCGGCTGCGAGCACCACTGCACCAACCTGGCCGGCTCCTTCCAGTGCTCC       TGCGAGGCCGGCTACCGGCTGCACGAGGACCGTAGGGGCTGCAGCGCCCTGGAGGAGCCGATGGTGGA       CCTGGACGGCGAGCTGCCTTTCGTGCGGCCCCTGCCCCACATTGCCGTGCTCCAGGACGAGCTGCCGC       AACTCTTCCAGGATGACGACGTCGGGGCCGATGAGGAAGAGGCAGAGTTGCGGGGCGAACACACGCTC       GAACGGAGGGACCTGCCTCCTGGGCCTGGATGGCTGTGATTGCCCCGAGGGCTGGACTGGGCTCATCT       AGCATGAGAGTTGTCCTCCGGACACCTTTGGGAAGAACTGCAGCTTCTCCTGCAGCTGTCAGAATGGT       GGGACCTGCGACTCTGTCACGGGGGCCTGCCGCTGCCCCCCGGGTGTCAGTGGAACTAACTGTGAGGA       TGGCTGCCCCAAGGGCTACTATGGCAAGCACTGTCGCAAGAAATGCAACTGTGCCAACCGGGGCCGGT       GCCACCGCCTCTACGGGGCCTGCCTCTGCGACCCAGGGCTCTACGGCCGCTTCTGCCACCTCGCCTGC       CCGCCGTGGGCCTTTGGGCCGGGCTGCTCGGAGGAGTGCCAGTGTGTGCAGCCCCACACGCAGTCCTG       TGACAAGAGGGATGGCAGCTGCTCCTGCAAGGCTGGCTTCCGGGGCGAGCGCTGTCAGGCAGAGTGTG       AGCCGGGCTACTTTGGGCCGGGGTGCTGGCAGGCATGCACCTGCCCAGTGGGCGTGGCCTGTGACTCC       GTGAGCGGCGAGTGTGGGAAGCGGTGTCCTGCTGGCTTCCAGGGAGAGGACTGTGGCCAAGAGTGCCC       GGTGGGGACCTTTGGCGTGAACTGCTCGAGCTCCTGCTCCTGTGGGGGGGCCCCCTGCCACGGGGTCA       CGGGGCAGTGCCGGTGTCCGCCGGGGAGGACTGGGGAAGACTGTGAGGCAGGTGAGTGTGAGGGCCTC       TGGGGGCTGGGCTGCCAGGAGATCTGCCCAGCATGCCATAACGCTGCTCGCTGCGACCCTGAGACCGG       AGCCTGCCTGTGCCTCCCTGGCTTTGTCGGCAGCCGCTGCCAGGACTGTGAGGCAGGCTGGTATGGTC       CCAGCTGCCAGACAATGTGCTCTTGTGCCAATGATGGGCACTGCCACCAAGACACGGGACACTGCAGC       TGTGCCCCCGGGTGGACCGGCTTTAGCTGCCAGAGAGCCTGTGATACTGGGCACTGGGGACCTGACTG       CAGCCACCCCTGCAACTGCAGCGCTGGCCACGGGAGCTGTGATGCCATCAGCGGCCTGTGTCTGTGTG       AGGCTGGCTACGTGGGCCCGCGGTGCGAGCAGTCAGAGTGTCCCCAGGGCCACTTTGGGCCCGGCTGT       GAGCAGCGGTGCCAGTGTCAGCATGGAGCAGCCTGTGACCACGTCAGCGGGGCCTGCACCTGCCCGGC       CGGCTGGAGGGGCACCTTCTGCGAGCATGCCTGCCCGGCCGGCTTCTTTGGATTGGACTGTCGCAGTG       CCTGCAACTGCACCGCCGGAGCTGCCTGTGATGCCGTGAATGGCTCCTGCCTCTGCCCCGCTGGCCGC       CGGGGCCCCCGCTGTGCCGAGAGTGCCTGCCCAGCCCACACCTACGGGCACAATTGCAGCCAGGCCTG       TGCCTGCTTTAACGGGGCCTCCTGTGACCCTGTCCACGGGCAGTGCCACTGTGCCCCTGGCTGGATGG       GGCCCTCCTGCCTGCAGGCCTGCCCTGCCGGCCTGTACGGCGACAACTGTCGGCATTCCTGCCTCTGC       CTGTGAGGTAGAGTGCCTCCCCCGGGACGTCAGAGCTGGCTGCCGGCACAGCGGCGGTTGCCTCAACG       GGGGCCTGTGTGACCCGCACACGGGCCGCTGCCTCTGCCCAGCCGGCTGGACTGGGGACAAGTGTCAG       AGCCCTGCAGCCTGTGCCAAGGGCACATTCGGGCCTCACTGTGAGGGGCGCTGTGCCTGCCGGTGGGG       AGGCCCCTGCCACCTTGCCACCGGGGCCTGCCTCTGCCCTCCGGGGTGGCGGGGGCCTCATCTTTCTG       CAGCCTGCCTGCGGGGCTGGTTTGGAGAGGCCTGTGCCCAGCGCTGCAGCTGCCCGCCTGGCGCTGCC       TGCCACCACGTCACTGGGGCCTGCCGCTGTCCCCCTGGCTTCACTGGCTCCGGCTGCGAGCAGGCCTG       CCCACCCGGCAGCTTTGGGGAGGACTGTGCGCAGATGTGCCAGTGTCCCGGTGAGAACCCGGCCTGCC       ACCCTGCCACCGGGACCTGCTCATGTGCTGCTGGCTACCACGGCCCCAGCTGCCAGCAACGATGTCCG       CCCGGGCGGTATGGGCCAGGCTGTGAACAGCTGTGTGGGTGTCTCAACGGGGGCTCCTGTGATGCGGC       CACGGGGGCCTGCCGCTGCCCCACTGGGTTCCTCGGGACGGACTGCAACCTCACCTGTCCGCAGGGCC       GCTTCGGCCCCAACTGCACCCACGTGTGTGGGTGTGGGCAGGGGGCGGCCTGCGACCCTGTGACCGGC       ACCTGCCTCTGCCCCCCGGGGAGAGCCGGCGTCCGCTGTGAGCGAGGCTGCCCCCAGAACCGGTTTGG       CGTGGGCTGCGAGCACACCTGCTCCTGCAGAAATGGGGGCCTGTGCCACGCCAGCAACGGCAGCTGCT       CCTGTGGCCTGGGCTGGACGGGGCGGCACTGCGAGCTGGCCTGTCCCCCTGGGCGCTACGGAGCCGCC       TGCCATCTGGAGTGCTCCTGCCACAACAACAGCACGTGTGAGCCTGCCACGGGCACCTGCCGCTGCGG       CCCCGGCTTCTATGGCCAGGCCTGCGAGCACCCCTGTCCCCCTGGCTTCCACGGGGCTGGCTGCCAGG       GGTTGTGCTGGTGTCAACATGGAGCCCCCTGCGACCCCATCAGTGGCCGATGCCTCTGCCCTGCCGGC       TTCCACGGCCACTTCTGTGAGAGGGGGTGTGAGCCAGGTTCATTTGGAGAGGGCTGCCACCAGCGCTG       TGACTGTGACGGGGGGGCACCCTGTGACCCTGTCACCGGTCTCTGCCTTTGCCCACCAGGGCGCTCAG       GGGGGTGGGGCTGACTGCGACCCTGTCAGTGGGCAGTGTCACTGTGTGGATGGCTACATGGGGCCCAC       GTGCCGGGAAGCGGGCACACTGCCCGCCTCCAGCAGACCCACATCCCGGAGCGGTGGACCAGCGAGGC       ACGAA TTCCCCGGGCTCGAGGGTAAGCCTATCCCTAACCCTCTCCTCGGTCTCGATTCTACGCGTACC           GGTCATCACCACCATCACCATTGAGTTTAATTCATTGATTT                                           NOV37o, CG56449-11                       Protein Sequence   SEQ ID NO: 886   1547 aa   MW at 161933.0kD                     SVPPRPLLPLQPGMPHVCAEQELTLVGRRQPCVQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQ           VYTTEARTVLRCCRGWMQQPDEEGCLSDVGECANANGGCAGRCRDTVGGFYCRWPPPSHQLQGDGETC       QDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCAINSCALGNGGCQHHCVQLTITRHRCQ       CRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQC       AHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELD       TDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAG       SFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELR       GEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNESCPPDTFGKNCSFSC       SCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRF       CHLACPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECEPGYFGPGCWQACTCPVG       VACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEAG       ECEGLWGLGCQEICPACHNAARCDPETGACLCLPGFVGSRCQDCEAGWYGPSCQTMCSCANDGHCHQD       TGHCSCAPGWTGFSCQHACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQSECPQGH       FGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCL       CPAGRRGPRCAESACPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCR       HSCLCQNGGTCDPVSGHCACPEGWAGLACEVECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWT       GDKCQSPAACAKGTFGPHCEGRCACRWGGPCHLATGACLCPPGWRGPHLSAACLRGWFGEACAQRCSC       PPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSC       QQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAAC       DPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPG       RYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRC       LCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCT       LHCDCGGGADCDPVSGQCHCVDGYMGPTCREAGTLPASSRPTSRSGGPARH                                     NOV37p,                   SNP13382514 of   SEQ ID NO: 887   877 bp       CG56449-04,   ORF Start: ATG at 25   ORF Stop: TAG at 535       DNA Sequence   SNP Pos: 430   SNP Change: G to A                       CCGGAGCTGCCTGTGATGCCGTGA   ATG GCTCCTGCCTCTGCCCCGCTGGCCGCCGGGGCCCCCGCTGT           GCCGAGACCTGCCCTGCCGGCCTGTACGGCGACAACTGTCGGCATTCCTGCCTCTGCCAGAACGGAGG       GACCTGTGACCCTGTCTCAGGCCTGCGAGCACCCCTGTCCCCCTGGCTTCCACGGGGCTGGCCGCCAG       GGGTTGTGCTGGTGTCAACATGGAGCCCCCTGCGACCCCATCAGTGGCCGATGCCTCTGCCCTGCCGG       CTTCCACGGCCACTTCTGTGAGAGGGATTGCAGAAGGGGCCAGTTTGGGCCCAGCTGCACCCTGCACT       GTGACTGCGGGGGTGGGGCTGACTGCGACCCTGTCAGTGGGCAGTGTCACTGTGTGGATGGCTACATG       GGGCCCACGTGCCGGGAAGGT   A   GGCCCCTCCGGCTCCCCGAGAACCCGTCCTTAGCCCAGGGCTCAGC       GGGCACACTGCCCGCCTCCAGCAGACCCACATCCCGGAGCGGTGGACCAGCGAGGCAC TAG   TAGAGGC           AGTCCCGTGGAGCCCGCCTCTCCAGTCCCAGCCAGAGGGGACCCTGGCCTTTGGTGACCACTGAGAAG           GACACTTCACGGGCCCAGAGCTCCTGGTACTGCCCTTCCTTTGAGGGCCGTGGAGGGCTGTGGACAGC           CCAGCAACCTGTCGCTCTTGGAGGCTGGTGTGGCCTTGAGGAGGGAAGCCTCGCATGGCCGCTGGAAG           AGAGGCGTCTCCTGGCCTGGCTCTGCAGAACCCAGGGGCACGCTCTGGGCCTGGGCTGAGGAAGTCCC           GCTCTCCCGCGGCTCTGAGTTGGACTGAGGACAGGTGTGGGCGCCAGTGTGGGTGCAGGCG                                           NOV37p,                       SNP13382514 of       CG56449-04,   SEQ ID NO: 888       MW at 17222.2kD       Protein Sequence   SNP Pos: 136   170 aa   SNP Change: Gly to Arg                     MAPASAPLAAGAPAVPRPALPACTATTVGIPASARTEGPVTLSQACEHPCPPGFHGAGRQGLCWCQHG           APCDPISGRCLCPAGFHGHFCERDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREGR       PLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 37B.  
                   TABLE 37B                       Comparison of the NOV37 protein sequences.                                            NOV37a   ------------------------------------------------------------           NOV37b   -----------------------------------------------MSFLEEARAAGRA       NOV37c   ------------------------------------------------------------       NOV37d   -------------------------------------------TGSTMSFLEEARAAGRA       NOV37e   SEQYSLLPRAPPDIIADRLTDCSFPWVFSAVTVLDTKLSRRSSRGSTMSFLEEAPAAGRA       NOV37f   --------------------------------------------HEALATMETDTLLLWV       NOV37g   -----------------------------------------------MPMGHSDRWSWRL       NOV37h   -----------------------------------------------MPMGHSDRWSWRL       NOV37i   -----------------------------------------------MPMGHSDRWSWRL       NOV37j   ------------------------------------------------------------       NOV37k   -----------------------------------------------MPMGHSDRWSWRL       NOV37l   -----------------------------------------------MPMGHSDRWSWRL       NOV37m   -----------------------------------------------MSFLEEARAAGRA       NOV37n   -----------------------------------------------MSFLEEARAAGPA       NOV37o   ------------------------------------------------------------               NOV37a   ------------------------------------------------------------       NOV37b   VVLALVLLLLPAVPVGASVPPRPLLPLQPG-----------MPHVCAEQELTLVGRRQPC       NOV37c   ------------------------------------------------------------       NOV37d   VVLALVLLLLPAVPVGASVPPRPLLPLQPG-----------MPHVCAEQELTLVGRRQPC       NOV37e   VVLALVLLLLPAVPVGASVPPRPLLPLQPG-----------MPHVCAEQELTLVGRRQPC       NOV37f   LLLWVPGSTGDAAQPARRARRTKLSRGSSVPPRPLLPLQPGMPHVCAEQELTLVGRRQPC       NOV37g   LRLALPLPVWLPAGGGRGADSPCLCS---------------RPHVCAEQELTLVGRRQPC       NOV37h   LRLALPLPVWLPAGGGRGADSPCLCS---------------RPHVCAEQELTLVGRRQPC       NOV37i   LRLALPLPVWLPAGGGRGADSPCLCS---------------RPHVCAEQELTLVGRRQPC       NOV37j   ------------------------------------------------------------       NOV37k   LRLALPLPVWLPAGGGRGADSPCLCS---------------RPHVCAEQELTLVGRRQPC       NOV37l   LRLALPLPVWLPAGGGRGADSPCLCS---------------RPHVCAEQELTLVGRRQPC       NOV37m   VVLALVLLLLPAVPVGASVPPRPLLPLQPG-----------MPHVCAEQELTLVGRRQPC       NOV37n   VVLALVLLLLPAVPVGASVPPRPLLPLQPG-----------MPHVCAEQELTLVGRRQPC       NOV37o   ---SVPPRPLLPLQPG-------------------------MPHVCAEQELTLVGRRQPC               NOV37a   ------------------------------------------------------------       NOV37b   VQALSHTVPVWRAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWTQQPDEEG       NOV37c   ------------------------------------------------------------       NOV37d   VQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWTQQPDEEG       NOV37e   VQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEG       NOV37f   VQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEG       NOV37g   VQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEG       NOV37h   VQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWTQQPDEEG       NOV37i   VQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWTQQPDEEG       NOV37j   ------------------------------------------------------------       NOV37k   VQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEG       NOV37l   VQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWTQQPDEEG       NOV37ni VQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEG       NOV37n   VQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEG       NOV37o   VQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEG               NOV37a   ------------------------------------------------------------       NOV37b   CLS--AECSASLCFHGGRCVPGS-AQPCHCPP---GFQGP-RCQYDVDECRTHNGGCQHR       NOV37c   ------------------------------------------------------------       NOV37d   CLS--AECSAGLCFHGGRCVPGS-AQPCHCPPG---FQGP-RCQYDVDECRTHNGGCQHR       NOV37e   CLSDVGECANANGGCAGRCRDTVGGFYCRWPPPSHQLQGDGETCQDVDECRTHNGGCQHR       NOV37f   CLSDVGECANANGGCAGRCRDTVGGFYCRWPPPSHQLQGDGETCQDVDECRTHNGGCQHR       NOV37g   CLSDVGECANANGGCAGRCRDTVGGFYCRWPPPSHQLQGDGETCQDVDECRTHNGGCQHR       NOV37h   CLS--AECSASLCFHGGRCVPGS-AQPCHCPP-G--FQGP-RCQYDVDECRTHNGGCQHR       NOV37i   CLS--AECSASLCFHGGRCVPGS-AQPCHCPPG---FQGP-RCQYDVDECRTHNGGCQHR       NOV37j   ------------------------------------------------------------       NOV37k   CLSDVGECANANGGCAGRCRDTVGGFYCRWPPPSHQLQGDGETCQDVDECRTHNGGCQHR       NOV37l   CLS--AECSASLCFHGGRCVPGS-AQPCHCPP-G--FQGP-RCQYDVDECRTHNGGCQHR       NOV37m   CLSDVGECANANGGCAGRCRDTVGGFYCRWPPPSHQLQGDGETCQDVDECRTHNGGCQHR       NOV37n   CLSDVGECANANGGCAGRCRDTVGGFYCRWPPPSHQLQGDGETCQDVDECRTHNGGCQHR       NOV37o   CLSDVGECANANGGCAGRCRDTVGGFYCRWPPPSHQLQGDGETCQDVDECRTHNGGCQHR               NOV37a   ------------------------------------------------------------       NOV37b   CVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQL       NOV37c   ------------------------------------------------------------       NOV37d   CVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQL       NOV37e   CVNTPGSYLCECKPGFRLHTDSRTC-AINSCALGNGGCQHHCVQLTITRHRCQCRPGFQL       NOV37f   CVNTPGSYLCECKPGFRLHTDSRTC-AINSCALGNGGCQHHCVQLTITRHRCQCRPGFQL       NOV37g   CVNTPGSYLCECKPGFRLHTDSRTC-ATNSCALGNGGCQHHCVQLTITRHRCQCRPGFQL       NOV37h   CVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQL       NOV37i   CVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQL       NOV37j   ------------------------------------------------------------       NOV37k   CVNTPGSYLCECKPGFRLHTDSRTC-AINSCALGNGGCQHHCVQLTITRHRCQCRPGFQL       NOV37l   CVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQL       NOV37m   CVNTPGSYLCECKPGFRLHTDSRTC-AINSCALGNGGCQHHCVQLTITRHRCQCRPGFQL       NOV37n   CVNTPGSYLCECKPGFRLHTDSRTC-AINSCALGNGGCQHHCVQLTITRHRCQCRPGFQL       NOV37o   CVNTPGSYLCECKPGFRLHTDSRTC-AINSCALGNGGCQHHCVQLTITRHRCQCRPGFQL               NOV37a   ------------------------------------------------------------       NOV37b   QEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQ       NOV37c   ------------------------------------------------------------       NOV37d   QEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQ       NOV37e   QEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQ       NOV37f   QEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQ       NOV37g   QEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGIAQ       NOV37h   QEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQ       NOV37i   QEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQ       NOV37j   ------------------------------------------------------------       NOV37k   QEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQ       NOV37l   QEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQ       NOV37m   QEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQ       NOV37n   QEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQ       NOV37o   QEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQ               NOV37a   ------------------------------------------------------------       NOV37b   CAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC       NOV37c   ------------------------------------------------------------       NOV37d   CAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC       NOV37e   CAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC       NOV37i   CAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC       NOV37g   CAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC       NOV37h   CAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC       NOV37i   CAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC       NOV37j   ------------------------------------------------------------       NOV37k   CAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC       NOV37l   CAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC       NOV37m   CAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC       NOV37n   CAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC       NOV37o   CAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC               NOV37a   ------------------------------------------------------------       NOV37b   TCPRGYELDTDQRTCIRCPRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDE       NOV37c   ------------------------------------------------------------       NOV37d   TCPRGYELDTDQRTCIDVGDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDE       NOV37e   TCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDE       NOV37f   TCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDE       NOV37g   TCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDE       NOV37h   TCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDE       NOV37i   TCPRGYELDTDQRTCTRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDE       NOV37j   ------------------------------------------------------------       NOV37k   TCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDE       NOV371   TCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDE       NOV37m   TCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDE       NOV37n   TCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDE       NOV37o   TCPRGYELDTDQRTCIRCRRLCRQPVLQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDE               NOV37a   ------------------------------------------------------------       NOV37b   CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHIA       NOV37c   ------------------------------------------------------------       NOV37d   CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIA       NOV37e   CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHIA       NOV37f   CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHIA       NOV37g   CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHIA       NOV37h   CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHIA       NOV37i   CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHIA       NOV37j   ------------------------------------------------------------       NOV37k   CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHIA       NOV37l   CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHIA       NOV37m   CASSRGGCEHHCTNLAGSFQCSCEAGYRIHEDRRGCSALEEPMVDLDGELPFVRPLPHIA       NOV37n   CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSALEEPMVDLDGELPFVRPLPHIA       NOV37o   CASSRGGCEHHCTNLAGSFQCSCEAGYRIHEDRRGCSALEEPMVDLDGELPFVRPLPHIA               NOV37a   ------------------------------------------------------------       NOV37b   VLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLL       NOV37c   ------------------------------------------------------------       NOV37d   VLQDELPQLFQDDDvGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLL       NOV37e   VLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLL       NOV37f   VLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLL       NOV37g   VLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLL       NOV37h   VLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLL       NOV37i   VLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLL       NOV37j   ------------------------------------------------------------       NOV37k   VLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLL       NOV37l   VLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLL       NOV37m   VLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLL       NOV37n   VLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLL       NOV37o   VLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLL               NOV37a   ------------------------------------------------------------       NOV37b   GLDGCDCPEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCE       NOV37c   ------------------------------------------------------------       NOV37d   GLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCE       NOV37e   GLDGCDCPEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCE       NOV37f   GLDGCDCPEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCE       NOV37g   GLDGCDCPEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCE       NOV37h   GLDGCDCPEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCE       NOV37i   GLDGCDCPEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCE       NOV37j   ------------------------------------------------------------       NOV37k   GLDGCDCPEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCE       NOV371   GLDGCDCPEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCE       NOV37m   GLDGCDCPEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCE       NOV37n   GLDGCDCPEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCE       NOV37o   GLDGCDCPEGWTGLICNESCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCE               NOV37a   ------------------------------------------------------------       NOV37b   DGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQ       NOV37c   ------------------------------------------------------------       NOV37d   DGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQ       NOV37e   DGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQ       NOV37f   DGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQ       NOV37g   DGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQ       NOV37h   DGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQ       NOV37i   DGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQ       NOV37j   ------------------------------------------------------------       NOV37k   DGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQ       NOV37l   DGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQ       NOV37m   DGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQ       NOV37n   DGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQ       NOV37o   DGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEECQ               NOV37a   ------------------------------------------------------------       NOV37b   CVQPHTQSCDKRDGSCSCKAGFRGERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECG       NOV37c   ------------------------------------------------------------       NOV37d   CVQPHTQSCDKRDGSCSCKAGFRGERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECG       NOV37e   CVQPHTQSCDKRDGSCSCKAGFRGERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECG       NOV37f   CVQPHTQSCDKRDGSCSCKAGFRGERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECG       NOV37g   CVQPHTQSCDKRDGSCSCKAGFRGERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECG       NOV37h   CVQPHTQSCDKRDGSCSCKAGFRGERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECG       NOV37i   CVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECG       NOV371   ------------------------------------------------------------       NOV37k   CVQPHTQSCDKRDGSCSCKAGFRGERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECG       NOV37l   CVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECG       NOV37m   CVQPHTQSCDKRDGSCSCKAGFRGERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECG       NOV37n   CVQPHTQSCDKRDGSCSCKAGFRGERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECG       NOV37o   CVQPHTQSCDKRDGSCSCKAGFRGERCQAECEPGYFGPGCWQACTCPVGVACDSVSGECG               NOV37a   ------------------------------------------------------------       NOV37b   KRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEAGECE       NOV37c   ------------------------------------------------------------       NOV37d   KRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPE       NOV37e   KRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEAGECE       NOV37f   KRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEAGECE       NOV37g   KRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEAGECE       NOV37h   KRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEAGECE       NOV37i   KRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPE       NOV37j   ------------------------------------------------------------       NOV37k   KRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEAGECE       NOV37l   KRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPE       NOV37m   KRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEAGECE       NOV37n   KRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEAGECE       NOV37o   KRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEAGECE               NOV37a   ------------------------------------------------------------       NOV37b   GLWGLGCQEICPACHNAARCDPETGACLCLPGFVGSRCQD-CEAGWYGPSCQTMCSCAND       NOV37c   ------------------------------------------------------------       NOV37d   GRWGLGCQEICPACQHAARCDPETGACLCLPDFVGSRCQDVCPAGWYGPSCQTRCSCAND       NOV37e   GLWGLGCQEICPACHNAARCDPETGACLCLPGFVGSRCQD-CEAGWYGPSCQTMCSCAND       NOV37f   GLWGLGCQEICPACHNAARCDPETGACLCLPGFVGSRCQD-CEAGWYGPSCQTMCSCAND       NOV37g   GLWGLGCQEICPACHNAARCDPETGACLCLPGFVGSRCQD-CEAGWYGPSCQTMCSCAND       NOV37h   GLWGLGCQEICPACHNAARCDPETGACLCLPGFVGSRCQD-CEAGWYGPSCQTMCSCAND       NOV37i   GRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCAND       NOV37j   ------------------------------------------------------------       NOV37k   GLWGLGCQEICPACHNAARCDPETGACLCLPGFVGSRCQD-CEAGWYGPSCQTMCSCAND       NOV37l   GRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCAND       NOV37m   GLWGLGCQEICPACHNAARCDPETGACLCLPGFVGSRCQD-CEAGWYGPSCQTMCSCAND       NOV37n   GLWGLGCQEICPACHNAARCDPETGACLCLPGFVGSRCQD-CEAGWYGPSCQTMCSCAND       NOV37o   GLWGLGCQEICPACHNAARCDPETGACLCLPGFVGSRCQD-CEAGWYGPSCQTMCSCAND               NOV37a   -------------------MAPASAPLAAGAPAVPRPALPACTATTVGIPASARTEGPVT       NOV37b   GHCHQDTGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGY       NOV37c   ----------DPCLAGPPLMAPASAPLAAGAPAVPRPALPACTATTVGIPASARTEGPVT       NOV37d   GHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGY       NOV37e   GHCHQDTGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGY       NOV37f   GHCHQDTGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGY       NOV37g   GHCHQDTGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGY       NOV37h   GHCHQDTGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGY       NOV37i   GHCHPATGHCSCAPGWTGFSCQPACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGY       NOV37j   -------------------MAPASAPLAAGAPAVPRPALPACTATTVGIPASARTEGPVT       NOV37k   GHCHQDTGHCSCAPGWTGFSCQEACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGY       NOV37l   GHCHPATGHCSCAPGWTGFSCQEACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGY       NOV37m   GHCHQDTGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGY       NOV37n   GHCHQDTGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGY       NOV37o   GHCHQDTGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGY               NOV37a   LSQACEH-PCPPGFHGAGRQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERDCRRGQFGP       NOV37b   VGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGL       NOV37c   LSQACEH-PCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERDCRRGQFGP       NOV37d   VGPRCEQ-QCPQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGL       NOV37e   VGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGL       NOV37f   VGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGL       NOV37g   VGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGL       NOV37h   VGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGL       NOV37i   VGPRCEQ-QCpQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGL       NOV37j   LSQACEH-PCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERDCRRGQFGP       NOV37k   VGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGL       NOV37l   VGPRCEQ-QCPQGHFGPGCEQLCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGL       NOV37m   VGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGL       NOV37n   VGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGL       NOV37o   VGPRCEQSECPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGL               NOV37a   SCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREG-------------------------       NOV37b   DCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAESACPAHTYGHNCSQACACFNGASCDP       NOV37c   SCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREG-------------------------       NOV37d   DCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAEK-------------------------       NOV37e   DCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAESACPAHTYGHNCSQACACFNGASCDP       NOV37f   DCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAESACPAHTYGHNCSQACACFNGASCDP       NOV37g   DCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAESACPAHTYGHNCSQACACFNGASCDP       NOV37h   DCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAESACPAHTYGHNCSQACACFNGASCDP       NOV37i   DCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAET-------------------------       NOV37j   SCTLHCDCGGGADCDPVSGQCHCVDGYMGPTCREG-------------------------       NOV37k   DCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAET-CPAHTYGHNCSQACACFNGASCDP       NOV37l   DCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAE------T-------------------       NOV37m   DCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAESACPAHTYGHNCSQACACFNGASCDP       NOV37n   DCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAESACPAHTYGHNCSQACACFNGASCDP       NOV37o   DCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAESACPAHTYGHNCSQACACFNGASCDP               NOV37a   ---------------------------------------------GPLRIPENPSLAQGS       NOV37b   VHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACE       NOV37c   ---------------------------------------------GPLRLPENPSLAQGS       NOV37d   ------------------------------------------------------------       NOV37e   VHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACE       NOV37f   VHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACE       NOV37g   VHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACE       NOV37h   VHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACE       NOV37i   -------------------CPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACE       NOV37j   ---------------------------------------------GPLRLPENPSLAQGS       NOV37k   VHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACE       NOV37l   -------------------CPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACE       NOV37m   VHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACE       NOV37n   VHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACE       NOV37o   VHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACE               NOV37a   AGTLPASSRPTSRSGGPARH----------------------------------------       NOV37b   VECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPHCEGR       NOV37c   AGTLPASSRPTSRS----------------------------------------------       NOV37d   --CLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSP---------------       NOV37e   VECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPHCEGR       NOV37f   VECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPHCEGR       NOV37g   VECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPHCEGR       NOV37h   VECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPHCEGR       NOV37i   KECPPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWAGDKCQS----------------       NOV37j   AGTLPASSRPTS------------------------------------------------       NOV37k   VECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPHCEGR       NOV37l   KECPPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQS----------------       NOV37m   VECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPHCEGR       NOV37n   VECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPHCEGR       NOV37o   VECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPAACAKGTFGPHCEGR               NOV37a   ------------------------------------------------------------       NOV37b   CACRWGGPCHLATGACLCPPGWRGPHLSAACLRGWFGEACAQRCSCPPGAACHHVTGACR       NOV37c   ------------------------------------------------------------       NOV37d   ----------------------------CLRG--WFGEACAQRCSCPPGAACHHVTGACR       NOV37e   CACRWGGPCHLATGACLCPPGWRGPHLSAACLRGWFGEACAQRCSCPPGAACHHVTGACR       NOV37f   CACRWGGPCHLATGACLCPPGWRGPHLSAACLRGWFGEACAQRCSCPPGAACHHVTGACR       NOV37g   CACRWGGPCHLATGACLCPPGWRGPHLSAACLRGWFGEACAQRCSCPPGAACHHVTGACR       NOV37h   CACRWGGPCHLATGACLCPPGWRGPHLSAACLRGWFGEACAQRCSCPPGAACHHVTGACR       NOV37i   -----------P----------------CLRG--WFGEACAQHCSCPPGAACHHVTGACR       NOV37j   ------------------------------------------------------------       NOV37k   CACRWGGPCHLATGACLCPPGWRGPHLSAACLRGWFGEACAQRCSCPPGAACHHVTGACR       NOV37l   --HP------------------HGPLLEASAALIFLQPACGAGLERPVPSAA-----AAR       NOV37m   CACRWGGPCHLATGACLCPPGWRGPHLSAACLRGWFGEACAQRCSCPPGAACHHVTGACR       NOV37n   CACRWGGPCHLATGACLCPPGWRGPHLSAACLRGWFGEACAQRCSCPPGAACHHVTGACR       NOV37o   CACRWGGPCHLATGACLCPPGWRGPHLSAACLRGWFGEACAQRCSCPPGAACHHVTGACR               NOV37a   ------------------------------------------------------------       NOV37b   CPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPP       NOV37c   ------------------------------------------------------------       NOV37d   CPPGFTGSGCEQGCP--------------------------------------------P       NOV37e   CPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPP       NOV37f   CPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPP       NOV37g   CPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPP       NOV37h   CPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPP       NOV37i   CPPGFTGSGCEQGCP--------------------------------------------P       NOV37j   ------------------------------------------------------------       NOV37k   CPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPP       NOV37l   LPLPATTSLGPAAVPLASL---------------A----------------PAASRDVRP       NOV37m   CPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPP       NOV37n   CPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPP       NOV37o   CPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPP               NOV37a   ------------------------------------------------------------       NOV37b   GRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGA       NOV37c   ------------------------------------------------------------       NOV37d   GRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGA       NOV37e   GRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGA       NOV37f   GRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGA       NOV37g   GRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGA       NOV37h   GRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGA       NOV37i   GRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGA       NOV37j   ------------------------------------------------------------       NOV37k   GRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGA       NOV37l   GGMGQAVNSCVGVSTGAPVMRPRGPAAAPLGSSGR--TATSP--------------VRPA       NOV37m   GRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGA       NOV37n   GRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGA       NOV37o   GRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGA               NOV37a   ------------------------------------------------------------       NOV37b   ACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASGACATPASGSCS       NOV37c   ------------------------------------------------------------       NOV37d   ACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHAS-------NGSCS       NOV37e   ACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHAS-------NGSCS       NOV37f   ACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHAS-------NGSCS       NOV37g   ACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHAS-------KRQLL       NOV37h   ACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHAS-------KRQLL       NOV37i   ACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHAS-------NGSCS       NOV37j   ------------------------------------------------------------       NOV37k   ACDPVTGTCLCPPGRAGVRCERGCPQNRPGVGCEHTCSCRNGGLCHAS-------KRQLL       NOV37l   ASAPTAPTCVVVG--------RGRPATL--------------------------------       NOV37m   ACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHAS-------NGSCS       NOV37n   ACDPVTGTCLCPPGPAGVRCERGCPQNRFGVGCEHTCSCPNGGLCHAS-------NGSCS       NOV37o   ACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCPNGGLCHAS-------NGSCS               NOV37a   ------------------------------------------------------------       NOV37b   CGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPG       NOV37c   ------------------------------------------------------------       NOV37d   CGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPG       NOV37e   CGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPG       NOV37f   CGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPG       NOV37g   LWPGLDGAALRAGLSPWALRSRLPSGVLLPQQQHV-------------------------       NOV37h   LWPGLDGAALRAGLSPWALRSRLPSGVLLPQQQHV-------------------------       NOV37i   CGLGWTGRHCELACPPGRYGAACHLECSCHNNSTGEPATGTCRCGPGFYGQACEHPCPPG       NOV37j   ------------------------------------------------------------       NOV37k   LWPGLDGAALRAGLSPWALRSRLPSGVLLPQQQHV-------------------------       NOV37l   ------------------------------------------------------------       NOV37m   CGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPG       NOV37n   CGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPG       NOV37o   CGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPG               NOV37a   ------------------------------------------------------------       NOV37b   FHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAP       NOV37c   ------------------------------------------------------------       NOV37d   FHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAP       NOV37e   FHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAP       NOV37f   FHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAP       NOV37g   ------------------------------------------------------------       NOV37h   ------------------------------------------------------------       NOV37i   FHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAP       NOV37j   ------------------------------------------------------------       NOV37k   ------------------------------------------------------------       NOV37l   ------------------------------------------------------------       NOV37m   FHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAP       NOV37n   FHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAP       NOV37o   FHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAP               NOV37a   ------------------------------------------------------------       NOV37b   CDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGP       NOV37c   ------------------------------------------------------------       NOV37d   CDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGP       NOV37e   CDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGP       NOV37f   CDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGP       NOV37g   ------------------------------------------------------------       NOV37h   ------------------------------------------------------------       NOV37i   CDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGP       NOV37j   ------------------------------------------------------------       NOV37k   ------------------------------------------------------------       NOV37l   ------------------------------------------------------------       NOV37m   CDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGP       NOV37n   CDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGP       NOV37o   CDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMGP               NOV37a   ------------------------------------------------------------       NOV37b   TCREGGPLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH--------------------       NOV37c   ------------------------------------------------------------       NOV37d   TCREGGPLRLPENPSLAQGSAGTLPASSRPTSRSGGPARHGTG-----------------       NOV37e   TCREAG----------------TLPASSRPTSRSGGPARHVFPGLEGKPIPNPLLGLDST       NOV37f   TCREAG----------------TLPASSRPTSRSGGPARHEFPGLEGKPIPNPLLGLDST       NOV37g   ------------------------------------------------------------       NOV37h   ------------------------------------------------------------       NOV37i   TCREGGPLRLPENPSLLAQGSAGTLPASSRPTSRSGGPARH-------------------       NOV37j   ------------------------------------------------------------       NOV37k   ------------------------------------------------------------       NOV37l   ------------------------------------------------------------       NOV37m   TCREAG----------TLPASSRPTSRSGGPARH--------------------------       NOV37n   TCREAG----------TLPASSRPTSRSGGPARH--------------------------       NOV37o   TCREAG----------TLPASSRPTSRSGGPARH--------------------------               NOV37a   ---------       NOV37b   ---------       NOV37c   ---------       NOV37e   RTGHHHHHH       NOV37f   RTGHHHHHH       NOV37g   ---------       NOV37h   ---------       NOV37i   ---------       NOV37j   ---------       NOV37k   ---------       NOV37l   ---------       NOV37m   ---------       NOV37n   ---------       NOV37o   ---------               NOV37a   (SEQ ID NO: 858)       NOV37b   (SEQ ID NO: 860)       NOV37c   (SEQ ID NO: 862)       NOV37d   (SEQ ID NO: 864)       NOV37e   (SEQ ID NO: 866)       NOV37f   (SEQ ID NO: 868)       NOV37g   (SEQ ID NO: 870)       NOV37h   (SEQ ID NO: 872)       NOV37i   (SEQ ID NO: 874)       NOV37j   (SEQ ID NO: 876)       NOV37k   (SEQ ID NO: 878)       NOV37l   (SEQ ID NO: 880)       NOV37m   (SEQ ID NO: 882)       NOV37n   (SEQ ID NO: 884)       NOV37o   (SEQ ID NO: 886)                  
 
      Further analysis of the NOV37a protein yielded the following properties shown in Table 37C.  
               TABLE 37C                       Protein Sequence Properties NOV37a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 0; pos. chg 0; neg. chg 0           H-region:   length 16; peak value 6.60           PSG score:   2.20                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −5.33           possible cleavage site: between 14 and 15                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 0           number of TMS(s) . . . fixed                             PERIPHERAL   Likelihood = 5.83 (at 18)                         ALOM score: 5.83 (number of TMSs: 0)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 6           Charge difference: 0.0 C(1.0)-N(1.0)           N &gt;= C: N-terminal side will be inside       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   2   Hyd Moment(75):   1.11           Hyd Moment(95):   2.89   G content:   2           D/E content:   1   S/T content:   6                         Score: −3.38       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 45 ART|EG                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 7.1%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 94.1       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         65.2%: nuclear           21.7%: mitochondrial            8.7%: cytoplasmic            4.3%: extracellular, including cell wall                 &gt;&gt; prediction for CG56449-04 is nuc (k = 23)                  
 
      A search of the NOV37a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 37D.  
               TABLE 37D                          Geneseq Results for NOV37a                                         NOV37a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value                                             AAY72716   HMEIR04 clone human attractin-like   38 . . . 170   126/176   (71%)   6e−73           protein -  Homo sapiens , 310 aa.   135 . . . 310    126/176   (71%)           [WO200116156-A1, 08-MAR-2001]       AAY72715   HFICU08 clone human attractin-like   38 . . . 170   107/133   (80%)   4e−65           protein -  Homo sapiens , 474 aa.   342 . . . 474    108/133   (80%)           [WO200116156-A1, 08-MAR-2001]       AAY72740   HMEIR04 clone human attractin-like   55 . . . 170   113/159   (71%)   1e−63           partial protein -  Homo sapiens , 159 aa.    1 . . . 159   113/159   (71%)           [WO200116156-A1, 08-MAR-2001 ]       ABB72269   Murine protein isolated from skin cells   38 . . . 134   74/140   (52%)   4e−40           SEQ ID NO: 458 -  Mus  sp, 296 aa.   135 . . . 274    79/140   (55%)           [WO200190357-A1, 29-NOV-2001]       ABB72216   Murine protein isolated from skin cells   38 . . . 134   74/140   (52%)   4e−40           SEQ ID NO: 332 -  Mus  sp, 299 aa.   138 . . . 277    79/140   (55%)           [WO200190357-A1, 29-NOV-2001]                  
 
      In a BLAST search of public sequence databases, the NOV37a protein was found to have homology to the proteins shown in the BLASTP data in Table 37E.  
               TABLE 37E                          Public BLASTP Results for NOV37a                                         NOV37a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             O75095   MEGF6 -  Homo sapiens  (Human),   46 . . . 170   99/134   (73%)   5e−57           1246 aa (fragment).   1113 . . . 1246    105/134   (77%)       O88281   MEGF6 -  Rattus norvegicus  (Rat),   38 . . . 164   82/170   (48%)   1e−41           1574 aa.   1413 . . . 1571    93/170   (54%)       AAH39980   Hypothetical protein -  Mus musculus     38 . . . 134   74/140   (52%)   1e−39           (Mouse), 546 aa.   385 . . . 524    79/140   (55%)       Q8BKK7   MEGF11 protein -  Mus musculus     46 . . . 137   45/92   (48%)   7e−23           (Mouse), 947 aa.   183 . . . 274    54/92   (57%)       Q96KG6   MEGF11 protein (Hypothetical   46 . . . 137   45/92   (48%)   7e−23           protein KIAA1781) -  Homo sapiens     140 . . . 231    54/92   (57%)           (Human), 969 aa.                  
 
      PFam analysis predicts that the NOV37a protein contains the domains shown in the Table 37F.  
               TABLE 37F                          Domain Analysis of NOV37a                                     Identities/                   Similarities           NOV37a Match   for the   Expect       Pfam Domain   Region   Matched Region   Value               laminin_EGF   63 . . . 102   17/60 (28%)   0.37               30/60 (50%)       EGF   102 . . . 132    11/47 (23%)   0.16               23/47 (49%)                  
 
     Example 38  
      The NOV38 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 38A.  
               TABLE 38A                       NOV38 Sequence Analysis                                                NOV38a, CG56594-01   SEQ ID NO: 889   695 bp                             DNA Sequence   ORF Start: ATG at 53   ORF Stop: TGA at 662                             GCACCCTGGCCCAGCTCTGAGTCCTGGGACCCTCGGTCCTCTCTCCTGGGCCATGGCCAACTCAGGCC           TCCAGCTCCTGGGCTACTTCTTGGCCCTGGGTGGCTGGGTGGGCATCATTGCTAGCACAGCCCTGCCA       CAGTGGAAGCAGTCTTCCTACGCAGGCGACGCCATCATCACTGCCGTGGGCCTCTATGAAGGGCTCTG       GATGTCCTGCGCCTCCCAGAGCACTGGGCAAGTGCAGTGCAAGCTCTACGACTCGCTGCTCGCCCTGG       ACGGTAGGCCCCAGGCCGCGCGGGCCCTGATGGTGGTGGCCGTGCTCCTGGGCTTCGTGGCCATGGTC       CTCAGCGTAGTTGGCATGAAGTGTACGCGGGTGGGAGACAGCAACCCCATTGCCAAGGGCCGTGTTGC       CCCTGGTGACCCAGGAGTTCTTCAACCCAGAATTTGGCCCAGCCCTGTTCGTGGGCTGGGCCTCAGCT       GGCCTGGCCGTGCTGGGCGGCTCCTTCCTCTGCTGCACATGCCCGGAGCCAGAGAGACCCAACAGCAG       CCCACAGCCCTATCGGCCTGGACCCTCTGCTGCTGCCCGAGAGTACGTCTGAGCTCCGCCTGCCCTGG       CCAGCCCCCCACCCA                                         NOV38a, CG56594-01                                     Protein Sequence   SEQ ID NO: 890   203 aa   MW at 21174.4kD                             MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLYD           SLLALDGRPQAARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGGALFILAGLCTLTA       VSWYATLVTQEFFNPEFGPALFVGWASAGLAVLGGSFLCCTCPEPERPNSSPQPYRPGPSAAAREYV                                             NOV38b, 277685552   SEQ ID NO: 891   655 bp                             DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                             CACCGGATCCACCATGGCCAACTCAGGCCTCCAGCTCCTGGGCTACTTCTTGGCCCTGGGTGGCTGGG           TGGGCATCATTGCTAGCACAGCCCTGCCACAGTGGAAGCAGTCTTCCTACGCAGGCGACGCCATCATC       ACTGCCGTGGGCCTCTATGAAGGGCTCTGGATGTCCTGCGCCTCCCAGAGCACTGGGCAAGTGCAGTG       CAAGCTCTACGACTCGCTGCTCGCCCTGGACGGTCACATCCAATCAGCGCGGGCCCTGATGGTGGTGG       CCGTGCTCCTGGGCTTCGTGGCCATGGTCCTCAGCGTAGTTGGCATGAAGTGTACGCGGGTGGGAGAC       AGCAACCCCATTGCCAAGGGCCGTGTTGCCATCGCCGGGGGAGCCCTCTTCATCCTGGCAGGCCTCTG       CACTTTGACTGCTGTCTCGTGGTATGCCACCCTGGTGACCCAGGAGTTCTTCAACCCAAGCACACCTG       TCAATGCCAGGTATGAATTTGGCCCAGCCCTGTTCGTGGGCTGGGCCTCAGCTGGCCTGGCCGTGCTG       GGCGGCTCCTTCCTCTGCTGCACATGCCCGGAGCCAGAGAGACCCAACAGCAGCCCACAGCCCTATCG       GCCTGGACCCTCTGCTGCTGCCCGAGAGTACGTCGTCGACGGC                                         NOV38b, 277685552                                     Protein Sequence   SEQ ID NO: 892   218 aa   MW at 22694.0kD                             TGSTMANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQC           KLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGGALFILAGLC       TLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGSFLCCTCPEPERPNSSPQPYR       PGPSAAAREYVVDG                                             NOV38c, 277685649   SEQ ID NO: 893   583 bp                             DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                             CACCGGATCCAGCACAGCCCTGCCACAGTGGAAGCAGTCTTCCTACGCAGGCGACGCCATCATCACTG           CCGTGGGCCTCTATGAAGGGCTCTGGATGTCCTGCGCCTCCCAGAGCACTGGGCAAGTGCAGTGCAAG       CTCTACGACTCGCTGCTCGCCCTGGACGGTCACATCCAATCAGCGCGGGCCCTGATGGTGGTGGCCGT       GCTCCTGGGCTTCGTGGCCATGGTCCTCAGCGTAGTTGGCATGAAGTGTACGCGGGTGGGAGACAGCA       ACCCCATTGCCAAGGGCCGTGTTGCCATCGCCGGGGGAGCCCTCTTCATCCTGGCAGGCCTCTGCACT       TTGACTGCTGTCTCGTGGTATGCCACCCTGGTGACCCAGGAGTTCTTCAACCCAAGCACACCTGTCAA       TGCCAGGTATGAATTTGGCCCAGCCCTGTTCGTGGGCTGGGCCTCAGCTGGCCTGGCCGTGCTGGGCG       GCTCCTTCCTCTGCTGCACATGCCCGGAGCCAGAGAGACCCAACAGCAGCCCACAGCCCTATCGGCCT       GGACCCTCTGCTGCTGCCCGAGAGTACGTCGTCGACGGC                                         NOV38c, 277685649                                     Protein Sequence   SEQ ID NO: 894   194 aa   MW at 20246.1kD                             TGSSTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLYDSLLALDGHIQSARALMVVAV           LLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVN       ARYEFGPALFVGWASAGLAVLGGSFLCCTCPEPERPNSSPQPYRPGPSAAAREYVVDG                                             NOV38d, 277685616   SEQ ID NO: 895   556 bp                             DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                             CACCGGATCCTCAGGCCTCCAGCTCCTGGGCTACTTCTTGGCCCTGGGTGGCTGGGTGGGCATCATTG           CTAGCACAGCCCTGCCACAGTGGAAGCAGTCTTCCTACGCAGGCGACGCCATCATCACTGCCGTGGGC       CTCTATGAAGGGCTCTGGATGTCCTGCGCCTCCCAGAGCACTGGGCAAGTGCAGTGCAAGCTCTACGA       CTCGCTGCTCGCCCTGGACGGTCACATCCAATCAGCGCGGGCCCTGATGGTGGTGGCCGTGCTCCTGG       GCTTCGTGGCCATGGTCCTCAGCGTAGTTGGCATGAAGTGTACGCGGGTGGGAGACAGCAACCCCATT       GCCAAGGGCCGTGTTGCCATCGCCGGGGGAGCCCTCTTCATCCTGGCAGGCCTCTGCACTTTGACTGC       TGTCTCGTGGTATGCCACCCTGGTGACCCAGGAGTTCTTCAACCCAAGCACACCTGTCAATGCCAGGT       ATGAATTTGGCCCAGCCCTGTTCGTGGGCTGGGCCTCAGCTGGCCTGGCCGTGCTGGGCGGCTCCTTC       CTCGTCGACGGC                                         NOV38d, 277685616                                     Protein Sequence   SEQ ID NO: 896   185 aa   MW at 19131.1kD                             TGSSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLYD           SLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGGALFILAGLCTLTA       VSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGSFLVDG                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 38B.  
               TABLE 38B                       Comparison of the NOV38 protein sequences.                                            NOV38a   ----MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCAS                   NOV38b   TGSTMANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCAS               NOV38c   ------------------------TGSSTALPQWKQSSYAGDAIITAVGLYEGLWMSCAS               NOV38d   ----TGSSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCAS               NOV38a   QSTGQVQCKLYDSLLALDGRPQAARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKG               NOV38b   QSTGQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKG               NOV38c   QSTGQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKG               NOV38d   QSTGQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKG               NOV38a   RVAIAGGALFILAGLCTLTAVSWYATLVTQEFFNP--------EFGPALFVGWASAGLAV               NOV38b   RVAIAGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAV               NOV38c   RVAIAGGALFILGGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAV               NOV38d   RVAIAGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAV               NOV38a   LGGSFLCCTCPEPERPNSSPQPYRPGPSAAAREYV---               NOV38b   LGGSFLCCTCPEPERPNSSPQPYRPGPSAAAREYVVDG               NOV38c   LGGSFLCCTCPEPERPNSSPQPYRPGPSAAAREYVVDG               NOV38d   LGGSFLVDG-----------------------------               NOV38a   (SEQ ID NO: 890)               NOV38b   (SEQ ID NO: 892)               NOV38c   (SEQ ID NO: 894)               NOV38d   (SEQ ID NO: 896)                  
 
      Further analysis of the NOV38a protein yielded the following properties shown in Table 38C.  
               TABLE 38C                       Protein Sequence Properties NOV38a                                        SignalP analysis:   Cleavage site between residues 24 and 25       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 0; pos. chg 0; neg. chg 0           H-region:   length 30; peak value 9.10           PSG score:   4.70                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −4.10           possible cleavage site: between 17 and 18                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 4                                 INTEGRAL   Likelihood =   Transmembrane 8-24               −1.75           INTEGRAL   Likelihood =   Transmembrane 84-100               −12.15           INTEGRAL   Likelihood =   Transmembrane 118-134                −6.42           INTEGRAL   Likelihood =   Transmembrane 153-169                −0.64                             PERIPHERAL   Likelihood = 2.28 (at 39)                         ALOM score: −12.15 (number of TMSs: 4)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 15           Charge difference: −1.0 C(0.0)-N(1.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 3a                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   4.90           Hyd Moment(95):   7.23   G content:   6           D/E content:   1   S/T content:   5                         Score: −6.38       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 5.4%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 94.1       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         66.7%: endoplasmic reticulum           33.3%: mitochondrial                 &gt;&gt; prediction for CG56594-01 is end (k = 9)                  
 
      A search of the NOV38a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 38D.  
               TABLE 38D                          Geneseq Results for NOV38a                                         NOV38a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               ABG27980   Novel human diagnostic protein   1 . . . 203   200/211 (94%)    e−111           #27971 -  Homo sapiens , 254 aa.   44 . . . 254    201/211 (94%)           [WO200175067-A2, 11-OCT-2001 ]       AAO20545   Human Claudin-19 protein -  Homo     1 . . . 203   197/211 (93%)    e−109             sapiens , 211 aa. [WO200214499-A2,   1 . . . 211   198/211 (93%)           21-FEB-2002]       AAO20546   Murine Claudin-19 protein (partial   11 . . . 195    172/193 (89%)   1e−94           sequence) -  Mus  sp, 193 aa.   1 . . . 193   175/193 (90%)           [WO200214499-A2, 21-FEB-2002]       AAU96166   Human secreted protein, SEQ ID No   84 . . . 203    120/128 (93%)   2e−63           68 -  Homo sapiens , 128 aa.   1 . . . 128   120/128 (93%)           [WO200224721-A1, 28-MAR-2002]       ABG64826   Human albumin fusion protein #1501 -   84 . . . 203    120/128 (93%)   2e−63             Homo sapiens , 128 aa.   1 . . . 128   120/128 (93%)           [WO200177137-A1, 18-OCT-2001]                  
 
      In a BLAST search of public sequence databases, the NOV38a protein was found to have homology to the proteins shown in the BLASTP data in Table 38E.  
               TABLE 38E                          Public BLASTP Results for NOV38a                                         NOV38a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q8N6F1   Claudin-19 -  Homo sapiens  (Human),   1 . . . 203   200/211 (94%)    e−111           211 aa.   1 . . . 211   201/211 (94%)       Q9ET38   Claudin-19 -  Mus musculus  (Mouse),   1 . . . 203   191/211 (90%)    e−105           211 aa.   1 . . . 211   195/211 (91%)       O95832   Claudin-1 (Senescence-associated   1 . . . 203   115/212 (54%)   1e−62           epithelial membrane protein) -  Homo     1 . . . 211   151/212 (70%)             sapiens  (Human), 211 aa.       AAP35475   Claudin 7 -  Homo sapiens  (Human),   1 . . . 203   112/211 (53%)   3e−62           211 aa.   1 . . . 211   149/211 (70%)       Q8AVG4   Similar to claudin 1 -  Xenopus laevis     1 . . . 203   112/211 (53%)   6e−62           (African clawed frog), 211 aa.   1 . . . 211   142/211 (67%)                  
 
      PFam analysis predicts that the NOV38a protein contains the domains shown in the Table 38F.  
               TABLE 38F                          Domain Analysis of NOV38a                                     Identities/                   Similarities           NOV38a Match   for the   Expect       Pfam Domain   Region   Matched Region   Value                                         PMP22_Claudin   4 . . . 174   61/188   (32%)   1.7e−56               142/188   (76%)                  
 
     Example 39  
      The NOV39 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 39A.  
               TABLE 39A                       NOV39 Sequence Analysis                                                NOV39a, CG56653-08   SEQ ID NO: 897   1000 bp                             DNA Sequence   ORF Start: ATG at 2   ORF Stop: TAG at 980                             CATGGAGCTGAGTGGAGCCACCATGGCCCGGGGGCTCGCTGTCCTGCTAGTCTTGTTCCTGCATATCA           AGAACCTGCCTGCCCAGGCTGCGGACACATGTCCAGAGGTGAAGGTGGTGGGCCTGGAGGGCTCTGAC       AAGCTCACCATTCTCCGAGGCTGCCCGGGGCTGCCCGGGGCCCCAGGGCCAAAGGGAGAGGCAGGTGT       CATTGGAGAGAGAGGAGAACGCGGTCTCCCTGGAGCCCCTGGAAAGGCAGGACCAGTGGGGCCCAAGG       GAGACCGAGGAGAGAAGGGGATGCGTGGAGAGAAAGGAGACGCTGGGCAGTCTCAGTCGTGTGCGACA       GGCCCACGCAACTGCAAGGACCTGCTAGACCGGGGGTATTTCCTGAGCGGCTGGCACAATATCTACCT       GCCCGACTGCCGGCCCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGGGGCTGGACCGTTTTCC       AGCGGAGGATGGATGGCTCTGTGGACTTCTATCGGGACTGGGCCGCATACAAGCAGGGCTTCGGCAGT       CAGCTGGGGGAGTTCTGGCTGGGGAACGACAACATCCACGCCCTGACTGCCCAGGGAAGCAGCGAGCT       CCGTGTAGACCTGGTGGACTTTGAGGGCAACCACCAGTTTGCTAAGTACAAATCATTCAAGGTGGCTG       ACGAGGCAGAGAAGTACAAGCTGGTACTGGGAGCCTTTGTCGGGGGCAGTGCGGGTAATTCTCTAACG       GGCCACAACAACAACTTCTTCTCCACCAAAGACCAAGACAATGATGTGAGTTCTTCGAATTGTGCTGA       GAAGTTCCAGGGAGCCTGGTGGTACGCCGACTGTCATGCTTCGAGCCTCAATGGTCTCTACCTCATGG       GTGTCAGAGATGAAGGTGCGGCCCGCCTAGACGGGCCAGGACCCCTAA                                         NOV39a, CG56653-08                                     Protein Sequence   SEQ ID NO: 898   326 aa   MW at 35064.1kD                             MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGV           IGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHNIYL       PDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQGSSEL       RVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAE       KFQGAWWYADCHASSLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA                                             NOV39b, 214374274   SEQ ID NO: 899   651 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             GGATCCGGCCCACGCAACTGCAAGGACCTGCTAGACCGGGGGTATTTCCTGAGCGGCTGGACACCAT           CTACCTGCCCGACTGCCGGCCCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGGGGCTGGACCG       TTTTCCAGCGGAGGATGGATGGCTCTGTGGACTTCTATCGGGACTGGGCCGCATACAAGCAGGGCTTC       GGCAGTCAGCTGGGGGAGTTCTGGCTGGGGAACGACAACATCCACGCCCTGACTGCCCAGGGAAGCAG       CGAGCTCCGTGTAGACCTGGTGGACTTTGAGGGCAACCACCAGTTTGCTAAGTACAAATCATTCAAGG       TGGCTGACGAGGCAGAGAAGTACAAGCTGGTACTGGGAACCTTTGTCGGGGGCAGTGCGGGTAATTCT       CTAACGGGCCACAACAACAACTTCTTCTCCACCAAAGACCAAGACAATGATGTGAGTTCTTCGAATTG       TGCTGAGAAGTTCCAGGGAGCCTGGTGGTACGCCGACTGTCATGCTTCAAACCTCAATGGTCTCTACC       TCATGGGACCCCATGAGAGCTATGCCAATGGTATCAACTGGAGTGCGGCGAAGGGGTACAAATATAGC       TACAAGGTGTCAGAGATGAAGGTGCGGCCCGCCCTCGAG                                         NOV39b, 214374274                                     Protein Sequence   SEQ ID NO: 900   217 bp   MW at 24272.7kD                             GSGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGF           GSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNIIQFAKYKSFKVADEAEKYKLVLGTFVGGSAGNS       LTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYS       YKVSEMKVRPALE                                             NOV39c, 214374256   SEQ ID NO: 901   651 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             GGATCCGGCCCACGCAACTGCAAGGACCTGCTAGACCGGGGGTATTTCCTGAGCGGCTGGCACACCAT           CTACCTGCCCGACTGCCGGCCCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGGGGCTGGACCG       TTTTCCAGCGGAGGATGGATGGCTCTGTGGACTTCTATCGGGACTGGGCCGCATACAAGCAGGGCTTC       GGCAGTCAGCTGGGGGAGTTCTGGCTGGGGAATGACAACATCCACGCCCTGACTGCCCAGGGAAGCAG       CGAGCTCCGTGTAGACCTGGTGGACTTTGAGGGCAACCACCAGTTTGCTAAGTACAAATCATTCAAGG       TGGCTGACGAGGCAGAGAAGTACAAGCTGGTACTGGGAGCCTTTGTCGGGGGCAGTGCGGGTAATTCT       CTAACGGGCCACAACAACAACTTCTTCTCCACCAAAGACCAAGACAATGATGTGAGTTCTTCGAATTG       TGCTGAGAAGTTCCAAGGAGCCTGGTGGTACGCCGACTGTCATGCTTCAAACCTCAATGGTCTCTACC       TCATGGGACCCCATGAGAGCTATGCCAATGGTATCAACTGGAGTGCGGCGAAGGGGTACAAATATAGC       TACAAGGTGTCAGAGATGAAGGTGCGGCCCGCCCTCGAG                                         NOV39c, 214374256                                     Protein Sequence   SEQ ID NO: 902   217 aa   MW at 24242.6kD                             GSGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRPMDGSVDFYRDWAAYKQGF           LTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYS       YKVSEMKVRPALE                                             NOV39d, 214374252   SEQ ID NO: 903   651 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             GGATCCGGCCCACGCAACTGCAAGGACCTGCTAGACCGGGGGTATTTCCTGAGCGGCTGGCACACCAT           CTACCTGCCCGACTGCCGGCCCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGGGGCTGGACCG       GTTTCCAGCGGAGGATGGATGGCTCTGTGGACTTCTATCGGGACTGGGCCGCATACAAGCAGGGCTTC       GGCAGTCAGCTGGGGGAGTTCTGGCTGGGGAACGACAACATCCACGCCCTGACTGCCCAGGGAAGCAG       CGAGCTCCGTGTAGACCTGGTGGACTTTGAGGGCAACCACCAGTTTGCTAAGTACAAATCATTCAAGG       TGGCTGACGAGGCAGAGAAGTACAAGCTGGTACTGGGAGCCTTTGTCGGGGGCAGTGCGGGTAATTCT       CTAACGGGCCACAACAACAACTTCTTCTCCACCAAAGACCAAGACAATGATGTGAGTTCTTCGAATTG       TCATGGGACCCCATGAGAGCTATGCCAATGGTATCAACTGGAGTGCGGCGAAGGGGTACAAATATAGC       TACAAGGTGTCAGAGATGAAGGTGCGGCCCGCCCTCGAG                                         NOV39d, 214374252                                     Protein Sequence   SEQ ID NO: 904   217 aa   MW at 24200.6kD                             GSGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTGFQRRMDGSVDFYRDWAAYKQGF           GSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNS       LTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYS       YKVSEMKVRPALE                                             NOV39e, 214458492   SEQ ID NO: 905   651 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             GGATCCGGCCCACGCAACTGCAAGGACCTGCTAGACCGGGGGTATTTCCTGAGCGGCTGGCACACCAT           CTACCTGCCCGACTGCCGGCCCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGGGGTTGGACCG       TTTTCCAGCGGAGGATGGATGGCTCTGTGGACTTCTATCGGGACTGGGCCGCATACAAGCAGGGCTTC       GGCAGTCGGCTGGGGGAGTTCTGGCTGGGGAACGACAACATCCACGCCCTGACTGCCCAGGGAAGCAG       CGAGCTCCGTGTAGACCTGGTGGACTTTGAGGGCAACCACCAGTTTGCTAAGTACAAATCATTCAAGG       TGGCTGACGAGGCAGAGAAGTACAAGCTGGTACTGGGAGCCTTTGTCGGGGGCAGTGCGGGTAATTCT       CTAACGGGCCACAACAACAACTTCTTCTCCACCAAAGACCAAGACAATGATGTGAGTTCTTCGAATTG       TGCTGAGAAGTTCCAGGGAGCCTGGTGGTACGCCGACTGTCATGCTTCAAACCTCAATGGTCTCTACC       TCATGGGACCCCATGAGAGCTATGCCAATGGTATCAACTGGAGTGCGGCGAAGGGGTACAAATATAGC       TACAAGGTGTCAGAGATGAAGGTGCGGCCCGCCCTCGAG                                         NOV39e, 214458492                                     Protein Sequence   SEQ ID NO: 906   217 aa   MW at 24270.7kD                             GSRLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNS           LTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYS       YKVSEMKVRPALE                                             NOV39f, 214458488   SEQ ID NO: 907   651 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             GGATCCGGCCCACGCAACTGCAAGGACCTGCTAGACCGGGGGTATTTCCTGAGCGGCTGGCACACCAT           CTACCTGCCCGACTGCCGGCCCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGGGGCTGGACCG       TTTTCCAGCGGAGGATGGATGGCTCTGTGGACTTCTATCGGGACTGGGCCGCATACAAGCAGGGCTTC       GGCAGTCAGCTGGGGGAGTTCTGGCTGGGGAATGACGACATCCACGCCCTGACTGCCCAGGGAAGCAG       CGAGCTCCGTGTAGACCTGGTGGACTTTGAGGGCAACCACCAGTTTGCTAAGTACAAATCATTCAAGG       TGGCTGACGAGGCAGAGAAGTACAAGCTGGTACTGGGAGCCTTTGTCGGGGGCAGTGCGGGTAATTCT       CTAACGGGCCACAACAACAACTTCTTCTCCACCAAAGACCAAGACAATGATGTGAGTTCTTCGAATTG       TGCTGAGAAGTTCCAAGGAGCCTGGTGGTACGCCGACTGTCATGCTTCAAACCTCAATGGTCTCTACC       TCATGGGACCCCATGAGAGCTATGCCAATGGTATCAACTGGAGTGCGGCGAAGGGGTACAAATATAGC       TACAAGGTGTCAGAGATGAAGGTGCGGCCCGCCCTCGAG                                         NOV39f, 214458488                                     Protein Sequence   SEQ ID NO: 908   217 aa   MW at 24243.6kD                             GSGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGF           GSQLGEFWLGNDDIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNS       LTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYS       YKVSEMKVRPALE                                             NOV39g, 214374236   SEQ ID NO: 909   651 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             GGATCCGGCCCACGCAACTGCAAGGACCTGCTAGACCGAGGGCACTTCCTGAGCGGCTGGCACACCAT           CTACCTGCCCGACTGCCGGCCCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGGGGCTGGACCG       TTTTCCAGCGGAGGATGGATGGCTCTGTGGACTTCTATCGGGACTGGGCCGCATACAAGCAGGGCTTC       GGCAGTCAGCTGGGGGAGTTCTGGCTGGGGAACGACAACATCCACGCCCTGACTGCCCAGGGAAGCAG       CGAGCTCCGTGTAGACCTGGTGGACTTTGAGGGCAACCACCAGTTTGCTAAGTACAAATCATTCAAGG       TGGCTGACGAGGCAGAGAAGTACAAGCTGGTACTGGGAGCCTTTGTCGGGGGCAGTGCGGGTAATTCT       CTAACGGGCCACAACAACAACTTCTTCTCCACCAAAGACCAAGACAATGATGTGAGTTCTTCGAATTG       TGCTGAGAAGTTCCAAGGAGCCTGGTGGTACGCCGACTGTCATGCTTCAAACCTCAATGGTCTCTACC       TCATGGGACCCCATGAGAGCTATGCCAATGGTATCAACTGGAGTGCGGCGAAGGGGTACAAATATAGC       TACAAGGTGTCAGAGATGAAGGTGCGGCCCGCCCTCGAG                                         NOV39g 214374236                                     Protein Sequence   SEQ ID NO: 910   217 aa   MW at 24216.6kD                             GSGPRNCKDLLDRGHFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGF           GSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNS       LTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYS       YKVSEMKVRPALE                                             NOV39h, CG56653-01   SEQ ID NO: 911   1187 bp                             DNA Sequence   ORF Start: ATG at 16   ORF Stop: TAG at 973                             CTGAGTGGAGCCACCATGGCCCGGGGGCTCGCTGTCCTGCTAGTCTTGTTCCTGCATATCAAGAACCT           GCCTGCCCAGGCTGCGGACACATGTCCAGAGGTGAAGGTGGTGGGCCTGGAGGGCTCTGACAAGCTCA       CCATTCTCCGAGGCTGCCCGGGGCTGCCCGGGGCCCCAGGGCCAAAGGGAGAGGCAGGTGTCATTGGA       GAGAGAGGAGAACGCGGTCTCCCTGGAGCCCCTGGAAAGGCAGGACCAGTGGGGCCCAAAGGAGACCG       AGGAGAGAAGGGGATGCGTGGAGAGAAAGGAGACGCTGGGCAGTCTCAGTCGTGTGCGACAGGCCCAC       GCAACTGCAAGGACCTGCTAGACCGGGGGTATTTCCTGAGCGGCTGGCACACCATCTACCTGCCCGAC       TGCCGGCCCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGGGGCTGGACCGTTTTCCAGCGGAG       GATGGATGGCTCTGTGGACTTCTATCGGGACTGGGCCGCATACAAGCAGGGCTTCGGCAGTCAGCTGG       GGGAGTTCTGGCTGGGGAACGACAACATCCACGCCCTGACTGCCCAGGGAAGCAGCGAGCTCCGTGTA       GACCTGGTGGACTTTGAGGGCAACCACCAGTTTGCTAAGTACAAATCATTCAAGGTGGCTGACGAGGC       AGAGAAGTACAAGCTGGTACTGGGAGCCTTTGTCGGGGGCAGTGCGGGTAATTCTCTAACGGGCCACA       ACAACAACTTCTTCTCCACCAAAGACCAAGACAATGATGTGAGTTCTTCGAATTGTGCTGAGAAGTTC       CAGGGAGCCTGGTGGTACGCCGACTGTCATGCTTCAAACCTCAATGGTCTCTACCTCATGGGACCCCA       TGAGAGCTATGCCAATGGTATCAACTGGAGTGCGGCGAAGGGGTACAAATATAGCTACAAGGTGTCAG       AGATGAAGGTGCGGCCCGCCTAGACGGGCCAGGACCCCTCCACATGCACCTGCTAGTGGGGAGGCCAC       ACCCACAAGCGCTGCGTCGTGGAAGTCACCCCATTTCCCCAGCCAGACACACTCCCATGACGCCCACA       GCTGCCCCTTTGCCCCCAGCTCAGTCAAGCCGCCACATGCCCACAACCTCACCAGAGGGAGAATTATG       TTTCTAAATATGTTTACTTTGGGACAGAAAA                                         NOV39h, CG56653-01                                     Protein Sequence   SEQ ID NO: 912   319 aa   MW at 34388.3kD                             MARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGERGER           GLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYLPDCRPLT       VLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAOGSSELRVDLVDF       EGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWW       YADCHASNLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA                                             NOV39i, CG56653-02   SEQ ID NO: 913   1332 bp                             DNA Sequence   ORF Start: ATG at 183   ORF Stop: TAG at 1107                             TTTTAGGTCTGTTTGTCGTAGGCAGATGGAGCTTGTTATAATTATGCCTCATAGGGATAGTACAAGGA           AGGGGTAGGCTATGTGTTTTGTCAGGGAGTTGAGAAACTGTGGCACAAGGCGAGAGCTGGTTTCCTCT       GCCCTGTTAGAGCTGGGGGACTCTTCAGAGTCAAAGGCCAGAGAGCATGGAGCTGAGTGGAGCCACCA       TGGCCCGGGGGCTCGCTGTCCTGCTAGTCTTGTTCCTGCATATCAAGAACCTGCCTGCCCAGGCTGCG       GACACATGTCCAGAGGTGAAGGTGGTGGGCCTGGAGGGCTCTGGCAAGCTCACCATTCTCCGAGGCTG       CCCGGGGCTGCCCGGGGCCCCAGGGCCAAAGGGAGAGGCAGGTGTCATTGGAGAGAGAGGAGACCGAG       GAGAGAAGGGGATGCGTGGAGAGAAAGGAGACGCTGGGCAGTCTCAGTCGTGTGCGACAGGCCCACGC       AACTGCAAGGACCTGCTAGACCGGGGGTATTTCCTGAGCGGCTGGCACACCATCTACCTGCCCGACTG       CCGGCCCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGGGGCTGGACCGTTTTCCAGCGGAGGA       TGGATGGCTCTGTGGACTTCTATCGGGACTGGGCCGCATACAAGCAGGGCTTCGGCAGTCAGCTGGGG       GAGTTCTGGCTGGGGAATGACAACATCCACGCCCTGACTGCCCAGGGAAGCAGCGAGCTCCGTGTAGA       CCTGGTGGACTTTGAGGGCAACCACCAGTTTGCTAAGTACAAATCATTCAAGGTGGCTGACGAGGCAG       AGAAGTACAAGCTGGTACTGGGAGCCTTTGTCGGGGGCAGTGCGGGTAATTCTCTAACGGGCCACAAC       AACAACTTCTTCTCCACCAAAGACCAAGACAATGATGTGAGTTCTTCGAATTGTGCTGAGAAGTTCCA       AGGAGCCTGGTGGTACGCCGACTGTCATGCTTCAAACCTCAATGGTCTCTACCTCATGGGACCCCATG       AGAGCTATGCCAATGGTATCAACTGGAGTGCGGCGAAGGGGTACAAATATAGCTACAAGGTGTCAGAG       ATGAAGGTGCGGCCCGCCTAGACGGGCCAGGACCCCTCCACATGCACCTGCTAGTGGGGAGGCCACAC       CCACAAGCGCTGCGTCGTGGAAGTCACCCCATTTCCCCAGCCAGACACACTCCCATGACGCCCACAGC       TCTAATATGTTTACTTTTGGGGACAGAAAAAAAAAAAAA                                         NOV39i, CG56653-02                                     Protein Sequence   SEQ ID NO: 914   308 aa   MW at 33393.2kD                             MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSGKLTILRGCPGLPGAPGPKGEAGV           IGERGDRGEKGNRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGG       WTVFQRRNDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKS       FKVADEAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNG       LYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA                                             NOV39j, CG56653-03   SEQ ID NO: 915   728 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: TAG at 574                             CTGCATATCAAGAACCTGCCTGCCCAGGCTGCGGACACATGTCCAGAGGTGAAGGTGGTGGGCCTGGA           GGGCTCTGACAAGCTCACCATTCTCCGAGGCTGCCCGGGGCTGCCCGGGGCCCCAGGGCCAAAGGGAG       AGGCAGGTGTCATTGGAGAGAGAGGAGAACGCGGTCTCCCTGGAGCCCCTGGAAAGGCAGGACCAGTG       GGGCCCAAAGGAGACCGAGGAGAGAAGGGGATGCGTGGAGAGAAAGGAGACGCTGGGCAGTCTCAGTC       GTGTGCGACAGGCCCACGCAACTGCAAGGACCTGCTAGACCGGGGGTATTTCCTGAGCGGCTGGCACA       CCATCTACCTGCCCGACTGCCGGCCCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGGGGCTGG       ACCGTTTTCCAGGGAGCCTGGTGGTACGCCGACTGTCATGCTTCAAACCTCAATGGTCTCTACCTCAT       GGGACCCCATGAGAGCTATGCCAATGGTATCAACTGGAGTGCGGCGAAGGGGTACAAATATAGCTACA       GGAGGCCACACCCACAAGCGCTGCGTCGTGGAAGTCACCCCATTTCCCCAGCCAGACACACTCCCATG       ACGCCCACAGCTGCCCCTTTGCCCCCAGCTCAGTCAAGCCGCCACATG                                         NOV39j, CG56653-03                                     Protein Sequence   SEQ ID NO: 916   191 aa   MW at 20220.7kD                             LHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGERGERGLPGAPGKAGPV           GPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGW       TVFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA                                             NOV39k, CG56653-04   SEQ ID NO: 917   1104 bp                             DNA Sequence   ORF Start: ATG at 16   ORF Stop: TAG at 883                             CTGAGTGGAGCCACCATGGCCCGGGGGCTCGCTGTCCTGCTAGTCTTGTTCCTGCATATCACGAACCT           GCCTGCCCAGGCTGCGGACACATGTCCAGAGGTGAAGGTGGTGGGCCTGGAGGGCTCTGACAAGCTCA       CCATTCTCCGAGGCTGCCCGGGGCTGCCCGGGGCCCCAGGACCAAAGGGAGAGGCAGGTGTCATTGGA       GAGAAAGGAGACGCTGGGCAGTCTCAGTCGTGTGCGACAGGCCCACGCAACTGCAAGGACCTGCTAGA       CCGAGGGTATTTCCTGAGCGGCTGGCACACCATCTACCTGCCCGACTGCCGGCCCCTTACTGTGCTCT       GTGACATGGATACGGACGGAGGGGGCTGGACCGTTTTCCAGCGGAGGATGGATGGCTCTGTGGACTTC       TATCGGGACTGGGCCGCATACAAGCAGGGCTTCGGCAGTCAGCTGGGGGAGTTCTGGCTGGGGAATGA       CAACATCCACGCCCTGACTGCCCAGGGAAGCAGCGAGCTCCGTGTAGACCTGGTGGACTTTGAGGGCA       ACCACCAGTTTGCTAAGTACAAATCATTCAAGGTGGCTGACGAGGCAGAGAAGTACAAGCTGGTACTG       GGAGCCTTTGTCGGGGGCAGTGCGGGTAATTCTCTAACGGGCCACAACAACAACTTCTTCTCCACCAA       AGACCAAGACAATGATGTGAGTTCTTCGAATTGTGCTGAGAAGTTCCAGGGAGCCTGGTGGTACGCCG       ACTGTCATGCTTCAAACCTCAATGGTCTCTACCTCATGGGACCCCATGAGAGCTATGCCAATGGTATC       AACTGGAGTGCGGCGAAGGGGTACAAATATAGCTACAAGGTGTCAGAGATGAAGGTGCGGCCCGCCTA       AAGTCACCCCATTTCCCCAGCCAGACACACTCCCATGACGCCCACAGCTGCCCCTTTGCCCCCAGCTC       AGTCAAGCCGCCACATGCCCACAACCTCACCAGAGGGAGAATTATGTTTCTAAATATGTTTACTTTGG       GACAGAAAAAAAAAAA                                         NOV39k, CG56653-04                                     Protein Sequence   SEQ ID NO: 918   289 aa   MW at 31404.9kD                             MARGLAVLLVLFLHITNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGEKGDA           AYKQGFGSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGHQFAKYKSFKVADEAEKYKLVLGAFVG       GSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAA       KGYKYSYKVSEMKVRPA                                             NOV39l, CG56653-05   SEQ ID NO: 919   900 bp                             DNA Sequence   ORF Start: at 7   ORF Stop: at 895                             GGATCCGCGGACACATGTCCAGAGGTGAAGGTGGTGGGCCTGGAGGGCTCTGACAAGCTCACCATTCT           CCGAGGCTGCCCGGGGCTGCCCGGGGCCCCAGGGCCAAAGGGAGAGGCAGGTGTCATTGGAGAGAGAG       GAGAACGCGGTCTCCCTGGAGCCCCTGGAAAGGCAGGACCAGTGGGGCCCAAAGGAGACCGAGGAGAG       AAGGGGATGCGTGGAGAGAAAGGAGACGCTGGGCAGTCTCAGTCGTGTGCGACAGGCCCACGCAACTG       CAAGGACCTGCTAGACCGGGGGTATTTCCTGAGCGGCTGGCACACCATCTACCTGCCCGACTGCCGGC       CCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGGGGCTGGACCGTTTTCCAGCGGAGGATGGAT       GGCTCTGTGGACTTCTATCGGGACTGGGCCGCATACAAGCAGGGCTTCGGCAGTCAGCTGGGGGAGTT       CTGGCTGGGGAACGACAACATCCACGCCCTGACTGCCCAGGGAAGCAGCGAGCTCCGTGTAGACCTGG       TACAAGCTGGTACTGGGAGCCTTTGTCGGGGGCAGTGCGGGTAATTCTCTAACGGGCCACAACAACAA       CCTGGTGGTACGCCGACTGTCATGCTTCAAACCTCAATGGTCTCTACCTCATGGGACCCCATGAGAGC       TATGCCAATGGTATCAACTGGAGTGCGGCGAAGGGGTACAAATATAGCTACAAGGTGTCAGAGATGAA       GGGGCCCGCCCTCGAG                                         NOV39l, CG56653-05                                     Protein Sequence   SEQ ID NO: 920   296 aa   MW at 31819.1kD                             ADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKG           MRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGS       VDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYK       LVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYA       NGINWSAAKGYKYSYKVSEMKGPA                                             NOV39m, CG56653-06   SEQ ID NO: 921   988 bp                             DNA Sequence   ORF Start: ATG at 56   ORF Stop: TAG at 905                             GTTTCCTCTGCCCTGTTAGAGCTGGGGGACTCTTCAGAGTCAAAGGCCAGAGAGCATGGAGCTGAGTG           GAGCCACCATGGCCCGGGGGCTCGCTGTCCTGCTAGTCTTGTTCCTGCATATCAAGAACCTGCCTGCC       CAGGCTGCGGACACATGTCCAGAGGTGAAGGTGGTGGGCCTGGAGGGCTCTGACAAGCTCACCATTCT       CCGAGGCTGCCCGGGGCTGCCCGGGGCCCCAGGGCCAAAGGGAGAGGCAGGTGTCATTGGAGAGAGAG       GAGAACGCGGTCTCCCTGGAGCCCCTGGAAAGGCAGGACCAGTGGGGCCCAAAGGAGACCGAGGAGAG       AAGGGGATGCGTGGAGAGAAAGGAGACGCTGGGCAGTCTCAGTCGTGTGCGACAGGTCCACGCAACTG       CAAGGACCTGCTAGACCGGGGGTATTTCCTGAGCGGCTGGCACACCATCTACCTGCCCGACTGCCGGC       CCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGGGGCTGGACCGTTTTCCAGCGGAGGATGGAT       GGCTCTGTGGACTTTGAGGGCAACCACCAGTTTGCTAAGTACAAATCATTCAAGGTGGCTGACGAGGC       AGAGAAGTACAAGCTGGTACTGGGAGCCTTTGTCGGGGGCAGTGCGGGTAATTCTCTAACGGGCCACA       ACAACAACTTCTTCTCCACCAAAGACCAAGACAATGATGTGAGTTCTTCGAATTGTGCTGAGAAGTTC       CAAGGAGCCTGGTGGTACGCCGACTGTCATGCTTCAAACCTCAATGGTCTCTACCTCATGGGACCCCA       TGAGAGCTATGCCAATGGTATCAACTGCAGTGCGGCGAAGGGGTACAAATATAGCTACAAGGTGTCAG       AGATGAAGGTGCGGCCCGCCTAGACGGGCCAGGACCCCTCCACATGCACCTGCTAGTGGGGAGGCCAC       ACCCACAAGCGCTGCGTCGTGGAAGTCACCCATTTC                                         NOV39m, CG56653-06                                     Protein Sequence   SEQ ID NO: 922   283 aa   MW at 30136.7kD                             MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGV           IGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYL       PDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNS       LTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINCSAAKGYKYS       YKVSEMKVRPA                                             NOV39n, CG56653-07   SEQ ID NO: 923   970 bp                             DNA Sequence   ORF Start: at 2   ORF Stop: TAG at 950                             GGGGCTCGCTGTCATGCTAGTCTTGTTCCTGCATATCAAGAACCTGCCTGCCCAGGCTGCGGACACAT           GTCCAGAGGTGAAGGTGGTGGGCCTGGAGGGCTCTGACAAGCTCACCATTCTCCGAGGCTGCCCGGGG       CTGCCCGGGGCCCCAGGGCCAAAGGGAGAGGCAGGTGTCATTGGAGAGAGAGGAGAACGCGGTCTCCC       TGGAGCCCCTGGAAAGGCAGGACCAGTGGGGCCCAAAGGAGACCGAGGAGAGAAGGGGATGCGTGGAG       AGAAAGGAGACGCTGGGCAGTCTCAGTCGTGTGCGACAGGCCCACGCAACTGCAAGGACCTGCTAGAC       CGGGGGTATTTCCTGAGCGGCTGGCACACCATCTACCTGCCCGACTGCCGGCCCCTGACTGTGCTCTG       TGACATGGACACGGACGGAGGGGGCTGGACCGTTTTCCAGCGGAGGATGGATGGCTCTGTGGACTTCT       ATCGGGACTGGGCCGCATACAAGCAGGGCTTCGGCAGTCAGCTGGGGGAGTTCTGGCTGGGGAATGAC       AACATCCACGCCTTGACTGCCCAGGGAAGCAGCGAGCTCCGTGTAGACCTGGTGGACTTTGAGGGCAA       CCACCAGTTTGCTAAGTACAAATCATTCAAGGTGGCTGACGAGGCAGAGAAGTACAAGCTGGTACTGG       GAGCCTTTGTCGGGGGCAGTGCGGGTAATTCTCTAACGGGCCACAACAACAACTTCTTCTCCACCAAA       GACCAAGACAATGATGTGAGTTCTTCGAATTGTGCTGAGAAGTTCCAAGGAGCCTGGTGGTACGCCGA       CTGTCATGCTTCAAACCTCAATGGTCTCTACCTCATGGGACCCCATGAGAGCTATGCCAATGGTATCA       ACTGGAGTGCGGCGAAGGGGTACAAATATAGCTACAAGGTGTCAGAGATGAAGGTGCGGCCCGCCTAG       ACGGGCCAGGACCCCTCC                                         NOV39n, CG56653-07                                     Protein Sequence   SEQ ID NO: 924   316 aa   MW at 34047.9kD                             GLAVMLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTTLRGCPGLPGAPGPKGEAGVIGERGERGLP           DMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGN       HQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYAD       CHASNLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA                                             NOV39o, CG56653-09   SEQ ID NO: 925   1144 bp                             DNA Sequence   ORF Start: ATG at 183   ORF Stop: TAG at 981                             TTTTAGGTCTGTTTGTCGTAGGCAGATGGAGCTTGTTATAATTATGCCTCATAGGGATAGTACAAGGA           GCCCTGTTAGAGCTGGGGGACTCTTCAGAGTCAAAGGCCAGAGAGCATGGAGCTGAGTGGAGCCACCA       TGGCCCGGGGGCTCGCTGTCCTGCTAGTCTTGTTCCTGCATATCAAGAACCTGCCTGCCCAGGCTGCG       GACACATGTCCAGAGGTGAAGGTGGTGGGCCTGGAGGGCTCTGACAAGCTCACCATTCTCCGAGGCTG       CCCGGGGCTGCCCGGGGCCCCAGGGCCAAAGGGAGAGGCAGGTGTCATTGGAGAGAGAGGAGAACGCG       GTCTCCCTGGAGCCCCTGGAAAGGCAGGACCAGTGGGGCCCAAAGGAGACCGAGGAGAGAAGGGGATG       CGTGGAGAGAAAGGAGACGCTGGGCAGTCTCAGTCGTGTGCGACAGGCCCACGCAACTGCAAGGACCT       GCTAGACCGGGGGTATTTCCTGAGCGGCTGGCACACCATCTACCTGCCCGACTGCCGGCCCCTGACTG       TGCTCTGTGACATGGACACGGACGGAGGGGGCTGGACCGTTTTCCAGCGGAGGATGGATGGCTCTGTG       GACTTCTATCGGGACTGGGCCGCATACAAGCAGGGCTTCGGCAGTCAGCTGGGGGGTAATTCTCTAAC       GGGCCACAACAACAACTTCTTCTCCACCAAAGACCAAGACAATGATGTGAGTTCTTCGAATTGTGCTG       AGAAGTTCCAAGGAGCCTGGTGGTACGCCGACTGTCATGCTTCAAACCTCAATGGTCTCTACCTCATG       GGACCCCATGAGAGCTATGCCAATGGTATCAACTGGAGTGCGGCGAAGGGGTACAAATATAGCTACAA       GGTGTCAGAGATGAAGGTGCGGCCCGCCTAQACGGGCCAGGACCCCTCCACATGCACCTGCTAGTGGG       GAGGCCACACCCACAAGCGCTGCGTCGTGGAAGTCACCCCATTTCCCCAGCCAGACACACTCCCATGA       CGCCCACAGCTGCCCCTTTGCCCCCAGCTCAGTCAAGCCGCCACATGCCCACAACC                                         NOV39o, CG56653-09                                     Protein Sequence   SEQ ID NO: 926   266 aa   MW at 28476.8kD                             MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGV           IGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYL       PDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGGNSLTGHNNNFFSTKDQDND       VSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA                                             NOV39p, CG56653-10   SEQ ID NO: 927   651 bp                             DNA Sequence   ORF Start: at 7   ORF Stop: at 646                             GGATCCGGCCCACGCAACTGCAAGGACCTGCTAGACCGAGGGCACTTCCTGAGCGGCTGGCACACCAT           CTACCTGCCCGACTGCCGGCCCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGGGGCTGGACCG       TTTTCCAGCGGAGGATGGATGGCTCTGTGGACTTCTATCGGGACTGGGCCGCATACAAGCAGGGCTTC       GGCAGTCAGCTGGGGGAGTTCTGGCTGGGGAACGACAACATCCACGCCCTGACTGCCCAGGGAAGCAG       CGAGCTCCGTGTAGACCTGGTGGACTTTGAGGGCAACCACCAGTTTGCTAAGTACAAATCATTCAAGG       TGGCTGACGAGGCAGAGAAGTACAAGCTGGTACTGGGAGCCTTTGTCGGGGGCAGTGCGGGTAATTCT       CTAACGGGCCACAACAACAACTTCTTCTCCACCAAAGACCAAGACAATGATGTGAGTTCTTCGAATTG       TGCTGAGAAGTTCCAAGGAGCCTGGTGGTACGCCGACTGTCATGCTTCAAACCTCAATGGTCTCTACC       TCATGGGACCCCATGAGAGCTATGCCAATGGTATCAACTGGAGTGCGGCGAAGGGGTACAAATATAGC       TACAAGGTGTCAGAGATGAAGGTGCGGCCCGCCCTCGAG                                         NOV39p, CG56653-10                                     Protein Sequence   SEQ ID NO: 928   213 aa   MW at 23830.2kD                             GPRNCKDLLDRGHFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGS           QLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNSLT       GHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYSYK       VSEMKVRPA                                             NOV39q, CG56653-11   SEQ ID NO: 929   1045 bp                             DNA Sequence   ORF Start: ATG at 38   ORF Stop: TAG at 1016                             GAGCTGGGGGACTCTTCAGAGTCAAAGGCCAGAGAGCATGGAGCTGAGTGGAGCCACCATGGCCCGGG           GGCTCGCTGTCCTGCTAGTCTTGTTCCTGCATATCAAGAACCTGCCTGCCCAGGCTGCGGACACATGT       CCAGAGGTGAAGGTGGTGGGCCTGGAGGGCTCTGACAAGCTCACCATTCTCCGAGGCTGCCCGGGGCT       GCCCGGGGCCCCAGGGCCAAAGGGAGAGGCAGGTGTCATTGGAGAGAGAGGAGAACGCGGTCTCCCTG       GAGCCCCTGGAAAGGCAGGACCAGTGGGGCCCAAAGGAGACCGAGGAGAGAAGGGGATGCGTGGAGAG       AAAGGAGACGCTGGGCAGTCTCAGTCGTGTGCGACAGGCCCACGCAACTGCAAGGACCTGCTAGACCG       GGGGTATTTCCTGAGCGGCTGGCACACCATCTACCTGCCCGACTGCCGGCCCCTGACTGTGCTCTGTG       ACATGGACACGGACGGAGGGGGCTGGACCGTTTTCCAGCGGAGGATGGATGGCTCTGTGGACTTCTAT       CGGGACTGGGCCGCATACAAGCAGGGCTTCGGCAGTCAGCTGGGGGAGTTCTGGCTGGGGAACGACAA       CATCCACGCCCTGACTGCCCAGGGAAGCAGCGAGCTCCGTGTAGACCTGGTGGACTTTGAGGGCAACC       ACCAGTTTGCTAAGTACAAATCATTCAAGGTGGCTGACGAGGCAGAGAAGTACAAGCTGGTACTGGGA       GCCTTTGTCGGGGGCAGTGCGGGTAATTCTCTAACGGGCCACAACAACAACTTCTTCTCCACCAAAGA       CCAAGACAATGATGTGAGTTCTTCGAATTGTGCTGAGAAGTTCCAGGGAGCCTGGTGGTACGCCGACT       GTCATGCTTCAAACCTCAATGGTCTCTACCTCATGGGACCCCATGAGAGCTATGCCAATGGTATCAAC       TGGAGTGCGGCGAAGGGGTACAAATATAGCTACAAGGTGTCAGAGATGAAGGTGCGGCCCGCCTAGAC       GGGCCAGGACCCCTCCACATGCACC                                         NOV39q, CG56653-11                                     Protein Sequence   SEQ ID NO: 930   326 aa   MW at 35078.1kD                             MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGV           IGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYL       PDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQGSSEL       RVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAE       KFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA                                             NOV39r, CG56653-12   SEQ ID NO: 931   972 bp                             DNA Sequence   ORF Start: ATG at 10   ORF Stop: at 967                             GGATCCACCATGGCCCGGGGGCTCGCTGTCCTGCTAGTCTTGTTCCTGCATATCAAGAACCTGCCTGC           CCAGGCTGCGGACACATGTCCAGAGGTGAAGGTGGTGGGCCTGGAGGGCTCTGACAAGCTCACCATTC       TCCGAGGCTGCCCGGGGCTGCCCGGGGCCCCAGGGCCAAAGGGAGAGGCAGGTGTCATTGGAGAGAGA       GGAGAACGCGGTCTCCCTGGAGCCCCTGGAAAGGCAGGACCAGTGGGGCCCAAAGGAGACCGAGGAGA       GAAGGGGATGCGTGGAGAGAAAGGAGACGCTGGGCAGTCTCAGTCGTGTGCGACAGGCCCACGCAACT       GCAAGGACCTGCTAGACCGGGGGTATTTCCTGAGCGGCTGGCACACCATCTACCTGCCCGACTGCCGG       CCCCTGACTGTGCTCTGTGACATGGACACGGACGGAGGGGGCTGGACCGTTTTCCAGCGGAGGATGGA       TGGCTCTGTGGACTTCTATCGGGACTGGGCCGCATACAAGCAGGGCTTCGGCAGTCAGCTGGGGGAGT       TCTGGCTGGGGAACGACAACATCCACGCCCTGACTGCCCAGGGAAGCAGCGAGCTCCGTGTAGACCTG       GTGGACTTTGAGGGCAACCACCAGTTTGCTAAGTACAAATCATTCAAGGTGGCTGACGAGGCAGAGAA       GTACAAGCTGGTACTGGGAGCCTTTGTCGGGGGCAGTGCGGGTAATTCTCTAACGGGCCACAACAACA       ACTTCTTCTCCACCAAAGACCAAGACAATGATGTGAGTTCTTCGAATTGTGCTGAGAAGTTCCAGGGA       GCCTGGTGGTACGCCGACTGTCATGCTTCAAACCTCAATGGTCTCTACCTCATGGGACCCCATGAGAG       CTATGCCAATGGTATCAACTGGAGTGCGGCGAAGGGGTACAAATATAGCTACAAGGTGTCAGAGATGA       AGGTGCGGCCCGCCCTCGAG                                         NOV39r, CG56653-12                                     Protein Sequence   SEQ ID NO: 932   319 aa   MW at 34388.3kD                             MARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGERGER           GLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYLPDCRPLT       VLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQGSSELRVDLVDF       EGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWW       YADCHASNLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 39B.  
               TABLE 39B                       Comparison of the NOV39 protein sequences.                                            NOV39a   MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAP                   NOV39b   ------------------------------------------------------------               NOV39c   ------------------------------------------------------------               NOV39d   ------------------------------------------------------------               NOV39e   ------------------------------------------------------------               NOV39f   ------------------------------------------------------------               NOV39g   ------------------------------------------------------------               NOV39h   -------MARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAP               NOV39i   MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSGKLTILRGCPGLPGAP               NOV39j   -------------------LHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAP               NOV39k   -------MARGLAVLLVLFLHITNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAP               NOV39l   -----------------------------ADTCPEVKVVGLEGSDKLTILRGCPGLPGAP               NOV39m   MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAP               NOV39n   ----------GLAVMLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTTLRGCPGLPGAP               NOV39o   MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAP               NOV39p   ------------------------------------------------------------               NOV39q   MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAP               NOV39r   -------MARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAP               NOV39a   GPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKD               NOV39b   ---------------------------------------------------GSGPRNCKD               NOV39c   ---------------------------------------------------GSGPRNCKD               NOV39d   ---------------------------------------------------GSGPRNCKD               NOV39e   ---------------------------------------------------GSGPRNCKD               NOV39f   ---------------------------------------------------GSGPRNCKD               NOV39g   ---------------------------------------------------GSGPRNCKD               NOV39h   GPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKD               NOV39i   GPKGEAGVIGERG------------------DRGEKGMRGEKGDAGQSQSCATGPRNCKD               NOV39j   GPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKD               NOV39k   GPKGEAGVIGE------------------------------KGDAGQSQSCATGPRNCKD               NOV39l   GPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKD               NOV39m   GPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKD               NOV39n   GPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKD               NOV39o   GPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKD               NOV39p   -----------------------------------------------------GPRNCKD               NOV39q   GPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKD               NOV39r   GPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKD               NOV39a   LLDRGYFLSGWHNIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFG               NOV39b   LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFG               NOV39c   LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFG               NOV39d   LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTGFQRRMDGSVDFYRDWAAYKQGFG               NOV39e   LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFG               NOV39f   LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFG               NOV39g   LLDRGHFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFG               NOV39h   LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFG               NOV39i   LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFG               NOV39j   LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQ---------------------               NOV39k   LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFG               NOV39l   LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFG               NOV39m   LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFEGNHQFAKYKSF               NOV39n   LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFG               NOV39o   LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFY-----------               NOV39p   LLDRGHFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFG               NOV39q   LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFG               NOV39r   LLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFG               NOV39a   SQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFV               NOV39b   SQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGTFV               NOV39c   SQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFV               NOV39d   SQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFV               NOV39e   SRLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFV               NOV39f   SQLGEFWLGNDDIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFV               NOV39g   SQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFV               NOV39h   SQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFV               NOV39i   SQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFV               NOV39j   ------------------------------------------------------------               NOV39k   SQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFV               NOV39l   SQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFV               NOV39m   KVADEAEKYKL------------------------------------V-------LGAFV               NOV39n   SQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFV               NOV39o   ------RDWAA------------------------------------Y-------KQGFG               NOV39p   SQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFV               NOV39q   SQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFV               NOV39r   SQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFV               NOV39a   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASSLNGLYLMGPHESY               NOV39b   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39c   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39d   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39e   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39f   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39g   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39h   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39i   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39j   ----------------------------------GAWWYADCHASNLNGLYLMGPHESY               NOV39k   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39l   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39m   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39n   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39o   SQLGGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39p   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39q   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39r   GGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESY               NOV39a   ANGINWSAAKGYKYSYKVSEMKVRPA--               NOV39b   ANGINWSAAKGYKYSYKVSEMKVRPALE               NOV39c   ANGINWSAAKGYKYSYKVSEMKVRPALE               NOV39d   ANGINWSAAKGYKYSYKVSEMKVRPALE               NOV39e   ANGINWSAAKGYKYSYKVSEMKVRPALE               NOV39f   ANGINWSAAKGYKYSYKVSEMKVRPALE               NOV39g   ANGINWSAAKGYKYSYKVSEMKVRPALE               NOV39h   ANGINWSAAKGYKYSYKVSEMKVRPA--               NOV39i   ANGINWSAAKGYKYSYKVSEMKVRPA--               NOV39j   ANGINWSAAKGYKYSYKVSEMKVRPA--               NOV39k   ANGINWSAAKGYKYSYKVSEMKVRPA--               NOV39l   ANGINWSAAKGYKYSYKVSEMKGPA---               NOV39m   ANGINCSAAKGYKYSYKVSEMKVRPA--               NOV39n   ANGINWSAAKGYKYSYKVSEMKVRPA--               NOV39o   ANGINWSAAKGYKYSYKVSEMKVRPA--               NOV39p   ANGINWSAAKGYKYSYKVSEMKVRPA--               NOV39q   ANGINWSAAKGYKYSYKVSEMKVRPA--               NOV39r   ANGINWSAAKGYKYSYKVSEMKVRPA--               NOV39a   (SEQ ID NO: 898)               NOV39b   (SEQ ID NO: 900)               NOV39c   (SEQ ID NO: 902)               NOV39d   (SEQ ID NO: 904)               NOV39e   (SEQ ID NO: 906)               NOV39f   (SEQ ID NO: 908)               NOV39g   (SEQ ID NO: 910)               NOV39h   (SEQ ID NO: 912)               NOV39i   (SEQ ID NO: 914)               NOV39j   (SEQ ID NO: 916)               NOV39k   (SEQ ID NO: 918)               NOV39l   (SEQ ID NO: 920)               NOV39m   (SEQ ID NO: 922)               NOV39n   (SEQ ID NO: 924)               NOV39o   (SEQ ID NO: 926)               NOV39p   (SEQ ID NO: 928)               NOV39q   (SEQ ID NO: 930)               NOV39r   (SEQ ID NO: 932)                  
 
      Further analysis of the NOV39a protein yielded the following properties shown in Table 39C.  
               TABLE 39C                       Protein Sequence Properties NOV39a                                        SignalP analysis:   Cleavage site between residues 30 and 31       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 10; pos. chg 1; neg. chg 1           H-region:   length 12; peak value 11.35           PSG score:   6.95                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −3.79           possible cleavage site: between 29 and 30                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 6-22               −3.35                             PERIPHERAL   Likelihood = 4.51 (at 234)                         ALOM score: −3.35 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 13           Charge difference: −1.5 C(−0.5)-N(1.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 2 (cytoplasmic tail 1 to 6)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   1   Hyd Moment(75):   3.15           Hyd Moment(95):   5.83   G content:   2           D/E content:   2   S/T content:   2                         Score: −6.93       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 20 ARG|LA                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 10.7%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         KKXX-like motif in the C-terminus: KVRP                 SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         34.8%: mitochondrial           30.4%: cytoplasmic            8.7%: Golgi            8.7%: endoplasmic reticulum            4.3%: vacuolar            4.3%: extracellular, including cell wall            4.3%: nuclear            4.3%: vesicles of secretory system                 &gt;&gt; prediction for CG56653-08 is mit (k = 23)                  
 
      A search of the NOV39a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 39D.  
               TABLE 39D                          Geneseq Results for NOV39a                                         NOV39a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               AAR94183   Human 35 kDa opsonin protein P35 -   1 . . . 326   248/326 (76%)   e−146             Homo sapiens , 313 aa. [JP08038182-A,   1 . . . 313   266/326 (81%)           13-FEB-1996]       AAR30971   TGF-beta-1 binding protein -  Sus     1 . . . 324   239/324 (73%)   e−145             scrofa , 324 aa. [WO9222319-A1,   2 . . . 322   269/324 (82%)           23-DEC-1992]       AAR94179   Human 35 kDa opsonin protein P35   28 . . . 326    235/299 (78%)   e−140           fragment (III) residues 26-313 -  Homo     2 . . . 288   252/299 (83%)             sapiens , 288 aa. [JP08038182-A,           13-FEB-1996]       AAR94178   Human 35 kDa opsonin protein P35   109 . . . 326    180/218 (82%)   e−110           fragment (II) residues 96-313 -  Homo     1 . . . 218   194/218 (88%)             sapiens , 218 aa. [JP08038182-A,           13-FEB-1996]       AAB29658   Human membrane-associated protein   25 . . . 324    143/300 (47%)   1e−77            HUMAP-15 -  Homo sapiens , 299 aa.   21 . . . 299    189/300 (62%)           [WO200065054-A2, 02-NOV-2000]                  
 
      In a BLAST search of public sequence databases, the NOV39a protein was found to have homology to the proteins shown in the BLASTP data in Table 39E.  
               TABLE 39E                          Public BLASTP Results for NOV39a                                         NOV39a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             S61517   ficolin-1 precursor - human, 326 aa.   1 . . . 326   326/326   (100%)   0.0               1 . . . 326   326/326   (100%)       O00602   Ficolin 1 precursor (Collagen/fibrinogen   1 . . . 326   324/326   (99%)   0.0           domain-containing protein 1) (Ficolin-A)   1 . . . 326   325/326   (99%)           (Ficolin A) (M-Ficolin) -  Homo sapiens             (Human), 326 aa.       Q29042   Ficolin -  Sus scrofa  (Pig), 326 aa.   1 . . . 324   251/324   (77%)   e−153               1 . . . 324   278/324   (85%)       P57756   Ficolin 2 precursor (Collagen/fibrinogen   8 . . . 324   242/317   (76%)   e−150           domain-containing protein 2) (Ficolin-B)   1 . . . 317   270/317   (84%)           (Ficolin B) (Serum lectin p35) (EBP-37)           (Hucolin) -  Rattus norvegicus  (Rat), 319           aa.       Q29041   Ficolin -  Sus scrofa  (Pig), 323 aa.   1 . . . 324   240/324   (74%)   e−144               1 . . . 321   269/324   (82%)                  
 
      PFam analysis predicts that the NOV39a protein contains the domains shown in the Table 39F.  
               TABLE 39F                          Domain Analysis of NOV39a                                     Identities/                   Similarities           NOV39a Match   for the   Expect       Pfam Domain   Region   Matched Region   Value                                         Collagen   50 . . . 108   27/60   (45%)   3.1e−09               46/60   (77%)       fibrinogen_C   114 . . . 326    116/272   (43%)   2.2e−91               159/272   (58%)                  
 
     Example 40  
      The NOV40 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 40A.  
               TABLE 40A                       NOV40 Sequence Analysis                                                NOV40a, CG56806-01   SEQ ID NO: 933   1500 bp                             DNA Sequence   ORF Start: ATG at 74   ORF Stop: TGA at 1490                             CTTCCGAGCGGGCGCCCGTCCGCCCTGCCGCCGCCGCCGCCGCCGCTTCGCCTGCCGGCCTGAGAGCG           GGACCATGGATGAAAGGTTCAACAAGTGGCTGCTGACGCCGGTGCTCACTCTCCTCTTCGTGGTCATC       ATGTACCAGTACGTGTCCCCCTCCTGCACCAGCTCCTGCACCAACTTCGGGGAGCAGCCCCGCGCGGG       GGAGGCCGGCCCGCCCGCCGTCCCGGGTCCCGCCCGCCGGGCTCAGGCGCCGCCGGAGGAGTGGGAGC       AGAGGAGGCCCCAGTTGCCCCCGCCGCCCCGGGGGCCCCCCGAGGGACCTCGGGGGGCCGCGGCGCCG       GAGGAGGAGGACGAGGAGCCCGGAGACCCCCGGGAGGGGGAGGAAGAGGAGGAGGAAGACGAGCCGGA       CCCCGAGGCCCCGGAAAACGGCTCCCTGCCCCGATTCGTGCCGCGCTTCAACTTCAGCCTGAAGGACC       TGACCCGCTTCGTGGATTTCAACATCAAAGGGCGCGACGTGATCGTGTTCCTCCACATCCAGAAGACG       GGGGGCACCACTTTCGGCCGGCACCTGGTGAAGAACATCCGGCTGGAGCAGCCTTGTAGCTGCAAAGC       CCGGCTGGAGCTGCGGGCTGCACGCCGACTGGACGGAGCTCACCAACTGCGTGCCGGCCATCATGGAG       AAGAAGGACTGTCCCCGCAACCACAGCCACACCAGGAATTTCTATTACATCACAATGTTACGGGATCC       AGTGTCACGTTACCTGAGCGAGTGGAAACATGTCCAGAGAGGGGCCACTTGGAAAACCTCTCTTCATA       TGTGTGATGGAAGAAGCCCCACCCCAGATGAGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGG       GTCAGCTTGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGC       TGACCTCAGCCTGGTGGGCTGCTATAACTTGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGT       TGCAGAGTGCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTGAGTTCCAGAGGAAGACA       CAGTTTCTCTTTGAGAGAACATTCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAACATCACGCG       GGCTTCTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTGAGGATCTAAACTTCCTGGACATGC       AGCTTTACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCACCACACCAAGCAGCTAGAGCACCAG       AGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACAGGGACCACCAGTGGCCCAA       AGAAGATGGGGCTGCAGAAGGGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGTGACCTC       CTGC                                         NOV40a, CG56806-01                                     Protein Sequence   SEQ ID NO: 934   472 aa   MW at 54971.3kD                             MDERFNKWLLTPVLTLLFVVIMYQYVSPSCTSSCTNFGEQPRAGEAGPPAVPGPARRAQAPPEEWEQR           RPQLPPPPRGPPEGPRGAAAPEEEDEEPGDPREGEEEEEEDEPDPEAPENGSLPRFVPRFNFSLKDLT       RFVDFNIKGRDVIVFLHIQKTGGTTFGRHLVKNIRLEQPCSCKAGQKKCTCHRPGKKETWLFSRFSTG       WSCGLHADWTELTNCVPAIMEKKDCPRNHSHTRNFYYITMLRDPVSRYLSEWKHVQRGATWKTSLHMC       DGRSPTPDELPTCYPGDDWSGVSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESERNTILLQ       SAKNNLKNMAFFGLTEFQRKTQFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQL       YEYAKDLFQQRYHHTKQLEHQRDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRW                                             NOV40b, 248061366   SEQ ID NO: 935   750 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             CGCGGTACCTGTCCCCGCAACCACAGCCACACCAGGAATTTCTATTACATCACAATGTTACGGGATCC           AGTGTCACGTTACCTGAGCGAGTGGAAACATGTCCAGAGAGGGGCCACTTGGAAAACCTCTCTTCATA       TGTGTGATGGAAGAAGCCCCACCCCAGATGGGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGG       GTCAGCTTGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGC       TGACCTCAGCCTGGTGGGCTGCTATAACTTGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGT       TGCAGAGTGCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTGAGTTCCAGAGGAAGACA       CAGTTTCTCTTTGAGAGAACATTCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAACATCACGCG       GGCTTCTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTGAGGATCTAAACTTCCTGGACATGC       AGCTTTACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCACCACACCAAGCAGCTAGAGCACCAG       AGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACAGGGACCACCAGTGGCCCAA       AGAAGATGGGGCTGCAGAAGGGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGCTCGAGG       CG                                         NOV40b, 248061366                                     Protein Sequence   SEQ ID NO: 936   250 aa   MW at 29889.3kD                             RGTCPRNHSHTRNFYYITMLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDGLPTCYPGDDWSG           VSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESERNTILLQSAKNNLKNMAFFGLTEFQRKT       QFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYHHTKQLEHQ       RDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRWLEA                                             NOV40c, 246837961   SEQ ID NO: 937   750 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             CGCGGTACCTGTCCCCGCAACCACAGCCACACCAGGAATTTCTATTACATCACAATGTTACGGGATCC           AGTGTCACGTTACCTGAGTGAGTGGAAACATGTCCAGAGAGGGGCCACTTGGAAAACCTCTCTTCATA       TGTGTGATGGAAGAAGCCCCACCCCAGATGAGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGG       GTCAGCTTGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGC       TGACCTCAGCCTGGTGGGCTGCTATAACTTGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGT       TGCAGAGTGCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTGAGTTCCAGAGGAAGACA       CAGTTTCTCTTTGAGAGAACATTCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAACATCACGCG       GGCTTCTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTGAGGATCTAAACTTCCTGGACATGC       AGCTTTACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCACCACACCAAGCAGCTAGAGCGCCAG       AGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACAGGGACCACCAGTGGCCCAA       AGAAGATGGGGCTGCAGAAGGGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGCTCGAGG       CG                                         NOV40c, 246837961                                     Protein Sequence   SEQ ID NO: 938   250 aa   MW at 29980.4kD                             RGTCPRNHSHTRNFYYITMLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSG           VSLREFMDCTYNLANNRQVRLADLSLVGCYNLTFMNESERNTILLQSAKNNLKNMAFFGLTEFQRKT       QFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYHHTKQLERQ       RDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRWLEA                                             NOV40d, 246837965   SEQ ID NO: 939   750 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             CGCGGTACCTGTCCCCGCAACCACAGCCACACCAGGAATTTCTATTACATCACAATGTTACGGGATCC           AGTGTCACGTTACCTGAGTGAGTGGAAACATGCCCAGAGAGGGGCCACTTGGAAAACCTCTCTTCATA       TGTGTGATGGAAGAAGCCCCACCCCAGATGAGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGG       GTCAGCTTGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGC       TGACCTCAGCCTGGTGGGCTGCTATAACTTGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGT       TGCAGAGTGCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTGAGTTCCAGAGGAAGACA       CAGTTTCTCTTTGAGAGAACATTCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAACATCACGCG       GGCTTCTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTGAGGATCTAAACTTCCTGGACATGC       AGCTTTACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCACCACACCAAGCAGCTAGAGCACCAG       AGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACAGGGACCACCAGTGGCCCAA       AGAAGATGGGGCTGCAGAAGGGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGCTCGAGG       CG                                         NOV40d, 246837965                                     Protein Sequence   SEQ ID NO: 940   250 aa   MW at 29933.3kD                             RGTCPRNHSHTRNFYYITMLRDPVSRYLSEWKHAQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSG           VSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESERNTILLQSAKNNLKNMAFFGLTEFQRKT       QFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYHHTKQLEHQ       RDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRWLEA                                             NOV40e, 246837975   SEQ ID NO: 941   750 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             CGCGGTACCTGTCCCCGCAACCACAGCCACACCAGGAATTTCTATTACATCACAATGTTACGGGATCC           AGTGTCACGTTACCTGAGTGAGTGGAAACATGTCCAGAGAGGGGCCACTTGGAAAACCTCTCTTCATA       TGTGTGATGGAAGAAGCCCCACCCCAGATGAGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGG       GTCAGCTTGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGC       TGACCTCAGCCTGGTGGGCTGCTATAACTTGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGT       TGCAGAGTGCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTGAGTTCCAGAGGAAGACA       CAGTTTCTCTTTGAGAGAGCATTCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAACATCACGCG       GGCTTCTAACGTGGAGATCAACGAGGGTGCCCACCAACGCATTGAGGATCTAAACTTCCTGGACATGC       AGCTTTACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCACCACGCCAAGCAGCTAGAGCACCAG       AGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACAGGGACCACCAGTGGCCCAA       AGAAGATGGGGCTGCAGAAGGGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGCTCGAGG       CG                                         NOV40e, 246837975                                     Protein Sequence   SEQ ID NO: 942   250 aa   MW at 29882.2kD                             RGTCPRNHSHTPNFYYITMLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSG           VSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESERNTILLQSAKNNLKNMAFFGLTEFQRKT       QFLFERAFNLKFISPFTQFNITRASNVEINEGAHQRIEDLNFLDMQLYEYAKDLFQQRYHHAKQLEHQ       RDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRWLEA                                             NOV40f, 248061376   SEQ ID NO: 943   750 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             CGCGGTACCTGTCCCCGCAACCACAGCCACACCAGGAATTTCTATTACATCACAATGTTACGGGATCC           AGTGTCACGTTACCTGAGCGAGTGGAAACATGTCCAGAGAGGGGCCACTTGGAAAACCTCTCTTCATA       TGTGTGATGGAAGAAGCCCCACCCCAGATGAGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGG       GTCAGCTTGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGC       TGCAGAGTGCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTGAGTTCCAGAGGAAGACA       CAGTTTCTCTTTGAGAGAACATTCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAACATCACGCG       GGCTTCTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTGAGGATCTAAACTTCCTGGACATGC       AGCTTTACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCACCACACCAAGCAGCTAGAGCACCAG       AGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACAGGGACCACCAGTGGCCCAA       AGAAGATGGGGCTGCAGAAGGGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGCTCGAGG       CG                                         NOV40f, 248061376                                     Protein Sequence   SEQ ID NO: 944   250 aa   MW at 29961.3kD                             RGTCPRNHSHTRNFYYITMLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSG           VSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESERNTILLQSAKNNLKNMAFFGLTEFQRKT       QFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYHHTKQLEHQ       RDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRWLEA                                                 SEQ ID NO: 945   1500 bp                                 NOV40g, SNP13381685 of   ORF Start: ATG at 74   ORF Stop: TGA at 1490                             CG56806-01, DNA Sequence   SNP Pos: 870   SNP Change: A to G                             CTTCCGAGCGGGCGCCCGTCCGCCCTGCCGCCGCCGCCGCCGCCGCTTCGCCTGCCGGCCTGAGAGCG           GGACCATGGATGAAAGGTTCAACAAGTGGCTGCTGACGCCGGTGCTCACTCTCCTCTTCGTGGTCATC       ATGTACCAGTACGTGTCCCCCTCCTGCACCAGCTCCTGCACCAACTTCGGGGAGCAGCCCCGCGCGGG       GGAGGCCGGCCCGCCCGCCGTCCCGGGTCCCGCCCGCCGGGCTCAGGCGCCGCCGGAGGAGTGGGAGC       AGAGGAGGCCCCAGTTGCCCCCGCCGCCCCGGGGGCCCCCCGAGGGACCTCGGGGGGCCGCGGCGCCG       GAGGAGGAGGACGAGGAGCCCGGAGACCCCCGGGAGGGGGAGGAAGAGGAGGAGGAAGACGAGCCGGA       CCCCGAGGCCCCGGAAAACGGCTCCCTGCCCCGATTCGTGCCGCGCTTCAACTTCAGCCTGAAGGACC       TGACCCGCTTCGTGGATTTCAACATCAAAGGGCGCGACGTGATCGTGTTCCTCCACATCCAGAAGACG       GGGGGCACCACTTTCGGCCGGCACCTGGTGAAGAACATCCGGCTGGAGCAGCCTTGTAGCTGCAAAGC       GGGTCAGAAGAAGTGCACCTGCCACCGGCCTGGCAAGAAGGAGACGTGGCTCTTCTCCCGCTTCTCCA       CCGGCTGGAGCTGCGGGCTGCACGCCGACTGGACGGAGCTCACCAACTGCGTGCCGGCCATCATGGAG       AAGAAGGACTGTCCCCGCAACCACAGCCACACCAGGAATTTCTATTACATCACAATGTTACGGGATCC       AGTGTCACGTTACCTGAGCGAGTGGAAACATGTCCAGAGAGGGGCCACTTGGAGAACCTCTCTTCATA       TGTGTGATGGAAGAAGCCCCACCCCAGATGAGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGG       GTCAGCTTGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGC       TGACCTCAGCCTGGTGGGCTGCTATAACTTGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGT       CAGTTTCTCTTTGAGAGAACATTCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAACATCACGCG       GGCTTCTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTGAGGATCTAAACTTCCTGGACATGC       AGCTTTACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCACCACACCAAGCAGCTAGAGCACCAG       AGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACAGGGACCACCAGTGGCCCAA       AGAAGATGGGGCTGCAGAAGGGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGTGACCTC       CTGC                                                 NOV40g, SNP13381685 of   SEQ ID NO: 946       MW at 54999.3kD                                 CG56806-01, Protein Sequence   SNP Pos: 266   472 aa   SNP Change: Lys to Arg                             MDERFNKWLLTPVLTLLFVVIMYQYVSPSCTSSCTNFGEQPRAGEAGPPAVPGPARRAQAPPEEWEQR           RPQLPPPPRGPPEGPRGAAAPEEEDEEPGDPREGEEEEEEDEPDPEAPENGSLPRFVPRFNFSLKDLT       RFVDFNIKGRDVIVFLHIQKTGGTTFGRHLVKNIRLEQPCSCKAGQKKCTCHRPGKKETWLFSRFSTG       WSCGLHADWTELTNCVPAIMEKKDCPRNHSHTRNFYYITMLRDPVSRYLSEWKHVQRGATWRTSLHMC       DGRSPTPDELPTCYPGDDWSGVSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESERNTILLQ       SAKNNLKNMAFFGLTEFQRKTQFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQL       YEYAKDLFQQRYHHTKQLEHQRDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRW                                                 SEQ ID NO: 947   1500 bp                                 NOV40h, SNP13381686 of   ORF Start: ATG at 74   ORF Stop: TGA at 1490                             CG56806-01, DNA Sequence   SNP Pos: 1190   SNP Change: T to C                             CTTCCGAGCGGGCGCCCGTCCGCCCTGCCGCCGCCGCCGCCGCCGCTTCGCCTGCCGGCCTGAGAGCG           GGACCATGGATGAAAGGTTCAACAAGTGGCTGCTGACGCCGGTGCTCACTCTCCTCTTCGTGGTCATC       ATGTACCAGTACGTGTCCCCCTCCTGCACCAGCTCCTGCACCAACTTCGGGGAGCAGCCCCGCGCGGG       GGAGGCCGGCCCGCCCGCCGTCCCGGGTCCCGCCCGCCGGGCTCAGGCGCCGCCGGAGGAGTGGGAGC       AGAGGAGGCCCCAGTTGCCCCCGCCGCCCCGGGGGCCCCCCGAGGGACCTCGGGGGGCCGCGGCGCCG       GAGGAGGAGGACGAGGAGCCCGGAGACCCCCGGGAGGGGGAGGAAGAGGAGGAGGAAGACGAGCCGGA       CCCCGAGGCCCCGGAAAACGGCTCCCTGCCCCGATTCGTGCCGCGCTTCAACTTCAGCCTGAAGGACC       TGACCCGCTTCGTGGATTTCAACATCAAAGGGCGCGACGTGATCGTGTTCCTCCACATCCAGAAGACG       GGGGGCACCACTTTCGGCCGGCACCTGGTGAAGAACATCCGGCTGGAGCAGCCTTGTAGCTGCAAAGC       GGGTCAGAAGAAGTGCACCTGCCACCGGCCTGGCAAGAAGGAGACGTGGCTCTTCTCCCGCTTCTCCA       CCGGCTGGAGCTGCGGGCTGCACGCCGACTGGACGGAGCTCACCAACTGCGTGCCGGCCATCATGGAG       AAGAAGGACTGTCCCCGCAACCACAGCCACACCAGGAATTTCTATTACATCACAATGTTACGGGATCC       AGTGTCACGTTACCTGAGCGAGTGGAAACATGTCCAGAGAGGGGCCACTTGGAAAACCTCTCTTCATA       TGTGTGATGGAAGAAGCCCCACCCCAGATGAGCTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGG       GTCAGCTTGCGGGAGTTTATGGATTGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGC       TGACCTCAGCCTGGTGGGCTGCTATAACTTGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGT       TGCAGAGTGCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTGAGTTCCAGAGGAAGACA       CAGTTTCTCTTTGAGAGAACATTCAACCTCAAGCTCATCTCCCCCTTCACACAGTTCAACATCACGCG       GGCTTCTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTGAGGATCTAAACTTCCTGGACATGC       AGCTTTACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCACCACACCAAGCAGCTAGAGCACCAG       AGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTGCAGCGAGAGCACAGGGACCACCAGTGGCCCAA       AGAAGATGGGGCTGCAGAAGGGACTGTCACCGAGGACTACAACAGCCAGGTGGTGAGATGGTGACCTC       CTGC                                                 NOV40h, SNP13381686 of   SEQ ID NO: 948       MW at 54937.3kD                                 CG56806-01, Protein Sequence   SNP Pos: 373   472 aa   SNP Change: Phe to Leu                             MDERFNKWLLTPVLTLLFVVIMYQYVSPSCTSSCTNFGEQPRAGEAGPPAVPGPARPAQAPPEEWEQR           RPQLPPPPRGPPEGPRGAAAPEEEDEEPGDPREGEEEEEEDEPDPEAPENGSLPRFVPRFNFSLKDLT       RFVDFNIKGRDVIVFLHIQKTGGTTFGRHLVKNIRLEQPCSCKAGQKKCTCHRPGKKETWLFSRFSTG       WSCGLHADWTELTNCVPAIMEKKDCPRNHSHTRNFYYITMLRDPVSRYLSEWKHVQRGATWKTSLHMC       DGRSPTPDELPTCYPGDDWSGVSLREFMDCTYNLANNRQVRMLADLSLVGCYNLTFMNESERNTILLQ       SAKNNLKNMAFFGLTEFQRKTQFLFERTFNLKLISPFTQFNITRASNVEINEGARQRIEDLNFLDMQL       YEYAKDLFQQRYHHTKQLEHQRDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRW                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 40B.  
               TABLE 40B                       Comparison of the NOV40 protein sequences.                                            NOV40a   MDERFNKWLLTPVLTLLFVVIMYQYVSPSCTSSCTNFGEQPRAGEAGPPAVPGPARRAQA                   NOV40b   ------------------------------------------------------------               NOV40c   ------------------------------------------------------------               NOV40d   ------------------------------------------------------------               NOV40e   ------------------------------------------------------------               NOV40f   ------------------------------------------------------------               NOV40a   PPEEWEQRRPQLPPPPRGPPEGPRGAAAPEEEDEEPGDPREGEEEEEEDEPDPEAPENGS               NOV40b   ------------------------------------------------------------               NOV40c   ------------------------------------------------------------               NOV40d   ------------------------------------------------------------               NOV40e   ------------------------------------------------------------               NOV40f   ------------------------------------------------------------               NOV40a   LPRFVPRFNFSLKDLTRFVDFNIKGRDVIVFLHIQKTGGTTFGRHLVKNIRLEQPCSCKA               NOV40b   ------------------------------------------------------------               NOV40c   ------------------------------------------------------------               NOV40d   ------------------------------------------------------------               NOV40e   ------------------------------------------------------------               NOV40f   ------------------------------------------------------------               NOV40a   GQKKCTCHRPGKKETWLFSRFSTGWSCGLHADWTELTNCVPAIMEKKDCPRNHSHTRNFY               NOV40b   ---------------------------------------------RGTCPRNHSHTRNFY               NOV40c   ---------------------------------------------RGTCPRNHSHTRNFY               NOV40d   ---------------------------------------------RGTCPRNHSHTRNFY               NOV40e   ---------------------------------------------RGTCPRNHSHTRNFY               NOV40f   ---------------------------------------------RGTCPRNHSHTRNFY               NOV40a   YITMLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFM               NOV40b   YITMLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDGLPTCYPGDDWSGVSLREFM               NOV40c   YITMLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFM               NOV40d   YITMLRDPVSRYLSEWKHAQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFM               NOV40e   YITMLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFM               NOV40f   YITMLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFM               NOV40a   DCTYNLANNRQVRMLADLSLVGCYNLTFMNESERNTILLQSAKNNLKNMAFFGLTEFQRK               NOV40b   DCTYNLANNRQVPMLADLSLVGCYNLTFMNESEENTILLQSAKNNLKNMAFFGLTEFQRK               NOV40c   DCTYNLANNRQVPMLADLSLVGCYNLTFMNESEENTILLQSAKNNLKNMAFFGLTEFQRK               NOV40d   DCTYNLANNRQVRMLADLSLVGCYNLTFMNESERNTILLQSAKNNLKNMAFFGLTEFQRK               NOV40e   DCTYNLANNRQVRMLADLSLVGCYNLTFMNESEENTILLQSAKNNLKNMAFFGLTEFQRK               NOV40f   DCTYNLANNRQVRNLADLSLVGCYNLTFMNESERNTILLQSAKNNLKNNAFFGLTEFQRK               NOV40a   TQFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRY               NOV40b   TQFLFERTFNLKFISPFTQFNITPASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRY               NOV40c   TQFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRY               NOV40d   TQFLFERTFNLKFISPFTQFNITEASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRY               NOV40e   TQFLFERAFNLKFISPFTQFNITRASNVEINEGAHQRIEDLNFLDMQLYEYAKDLFQQRY               NOV40f   TQFLFERTFNLKFISPFTQFNITFASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRY               NOV40a   HHTKQLEHQRDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRW--               NOV40b   HHTKQLEHQRDRQKEREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRWLEA               NOV40c   HHTKQLERQRDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRWLEA               NOV40d   HHTKQLEHQRDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRWLEA               NOV40e   HHAKQLEHQRDRQKEREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRWLEA               NOV40f   HHTKQLEHQRDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRWLEA               NOV40a   (SEQ ID NO: 934)               NOV40b   (SEQ ID NO: 936)               NOV40c   (SEQ ID NO: 938)               NOV40d   (SEQ ID NO: 940)               NOV40e   (SEQ ID NO: 942)               NOV40f   (SEQ ID NO: 944)                  
 
      Further analysis of the NOV40a protein yielded the following properties shown in Table 40C.  
               TABLE 40C                       Protein Sequence Properties NOV40a                                        SignalP analysis:   Cleavage site between residues 29 and 30       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 7; pos. chg 2; neg. chg 2           H-region:   length 31; peak value 11.61           PSG score:   7.21                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −5.24           possible cleavage site: between 28 and 29                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 8-24               −2.76                             PERIPHERAL   Likelihood =4.77 (at 312)                         ALOM score: −2.76 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 15           Charge difference: −2.0 C(−1.0)-N(1.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 2 (cytoplasmic tail 1 to 8)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   8.01           Hyd Moment(95):   7.59   G content:   0           D/E content:   2   S/T content:   0                         Score: −6.61       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 13.6%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: DERF                 none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 76.7       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         39.1%: mitochondrial           34.8%: nuclear           13.0%: cytoplasmic            4.3%: extracellular, including cell wall            4.3%: Golgi            4.3%: peroxisomal                 &gt;&gt; prediction for CG56806-01 is mit (k = 23)                  
 
      A search of the NOV40a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 40D.  
               TABLE 40D                          Geneseq Results for NOV40a                                         NOV40a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               AAO26610   Human 6-OST-3 protein sequence -   1 . . . 472   471/472 (99%)   0.0             Homo sapiens , 471 aa.   1 . . . 471   471/472 (99%)           [WO200279258-A2, 10-OCT-2002]       AAY83902   Mouse HS6ST2 protein -  Mus  sp, 470   1 . . . 472   447/472 (94%)   0.0           aa. [JP2000060566-A, 29-FEB-2000]   1 . . . 470   458/472 (96%)       ABP71364   Mouse H6ST-3 protein -  Mus  sp, 469   1 . . . 471   446/471 (94%)   0.0           aa. [WO2003004610-A2, 16-JAN-2003]   1 . . . 469   457/471 (96%)       ABP71362   Human AK polypeptide -  Homo     111 . . . 440    242/330 (73%)   e−149             sapiens , 460 aa. [WO2003004610-A2,   45 . . . 373    285/330 (86%)           16-JAN-2003]       AAO26608   Human 6-OST-2A protein sequence -   111 . . . 440    242/330 (73%)   e−149             Homo sapiens , 465 aa.   51 . . . 379    285/330 (86%)           [WO200279258-A2, 10-OCT-2002]                  
 
      In a BLAST search of public sequence databases, the NOV40a protein was found to have homology to the proteins shown in the BLASTP data in Table 40E.  
               TABLE 40E                          Public BLASTP Results for NOV40a                                         NOV40a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q8IZP7   Heparan sulfate 6-O-   1 . . . 472   469/472 (99%)   0.0           sulfotransferase 3 -  Homo sapiens     1 . . . 471   469/472 (99%)           (Human), 471 aa.       Q9QYK4   Heparan sulfate 6-sulfotransferase   1 . . . 472   447/472 (94%)   0.0           3 -  Mus musculus  (Mouse), 470 aa.   1 . . . 470   458/472 (96%)       AAH47151   Hs6st2 protein -  Mus musculus     111 . . . 440    244/330 (73%)   e−149           (Mouse), 535 aa (fragment).   114 . . . 442    285/330 (85%)       Q96SJ4   Hypothetical protein FLJ14814 -   111 . . . 440    242/330 (73%)   e−148             Homo sapiens  (Human), 459 aa.   45 . . . 373    285/330 (86%)       Q8NBN4   Hypothetical protein   111 . . . 440    241/330 (73%)   e−148           NT2RP2000358 -  Homo sapiens     51 . . . 379    285/330 (86%)           (Human), 465 aa.                  
 
      PFam analysis predicts that the NOV40a protein contains the domains shown in the Table 40F.  
               TABLE 40F                       Domain Analysis of NOV40a                                                Pfam Domain   NOV40a   Identities/   Expect           Match Region   Similarities   Value               for the               Matched Region                  
 
     Example 41  
      The NOV41 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 41A.  
               TABLE 41A                       NOV41 Sequence Analysis                                                NOV41a, CG56878-01   SEQ ID NO: 949   2739 bp                             DNA Sequence   ORF Start: ATG at 86   ORF Stop: TGA at 2090                             TTGCACTCTCCCACACCCTTTTCTTTTCGTCCGCTCTTCGCTTATTTCTCCCGCCGTCTCCTCTGCAT           AAGAAGGGGAACGAAAGATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGA       CTCCTGTTACCCGCAAGTCTGACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCG       TTATGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCAGAGCCAATCTTCGGACGTGGTGATTG       TCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTGAA       AGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGC       TCCCTGCTTGCTGAAGACAAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAAT       TGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTATGG       GTGCAGGTATCTCTGGGGACTACATCGATCGCGTGGACGAGCCCTTGTCCTGCTCTTATGTGCTGACC       ATTCGCACTCCTCGGCTCTGCCCCCACCCTCTCCTCCGGCCCCCACCCAGTGCTGCACCGCAGGCCAT       CCTCTGTCACCCTTCCCTACAGCCTGAGGAGTACATGGCCTACGTTCAGAGGCAAGCCGTAGACTCAA       AGCAGTATGGAGATAAAATCATAGAGGAGCTGCAAGATCTAGGCCCCCAAGTGTGGAGTGAGACCAAG       TCTGGGGTGGCACCCCAAAAGATGGCAGGTGCGAGCCCGACCAAGGATGACAGTAAGGACTCAGATTT       CTGGAAGATGCTTAATGAGCCAGAGGACCAGGCCCCAGGAGGGGAGGAGGTGCCGGCTGAGGAGCAGG       ACCCAAGCCCTGAGGCAGCAGATTCAGCTTCTGGTGCTCCCAATGATTTTCAGAACAACGTGCAGGTC       AAAGTCATTCGAAGCCCTGCGGATTTGATTCGATTCATAGAGGAGCTGAAAGGTGGAACAAAAAAGGG       GAAGCCAAATATAGGCCAAGAGCAGCCTGTGGATGATGCTGCAGAAGTCCCTCAGAGGGAACCAGAGA       AGGAAAGGGGTGATCCAGAACGGCAGAGAGAGATGGAAGAAGAGGAGGATGAGGATGAGGATGAGGAT       GAAGATGAGGATGAACGGCAGTTACTGGGAGAATTTGAGAAGGAACTGGAAGGGATCCTGCTTCCGTC       AGACCGAGACCGGCTCCGTTCGGAGGTGAAGGCTGGCATGGAGCGGGAACTGGAGAACATCATCCAGG       AGACAGAGAAAGAGCTGGACCCAGATGGGCTGAAGAAGGAGTCAGAGCGGGATCGGGCAATGCTGGCT       CTCACATCCACTCTCAACAAACTCATCAAAAGACTGGAGGAAAAACAGAGTCCAGAGCTGGTGAAGAA       GCACAAGAAAAAGAGGGTTGTCCCCAAAAAGCCTCCCCCATCACCCCAACCTACAGAGGAGGATCCTG       AGCACAGAGTCCGGGTCCGGGTCACCAAGCTCCGTCTCGGAGGCCCTAATCAGGATCTGACTGTCCTC       GAGATGAAACGGGAAAACCCACAGCTGAAACAAATCGAGGGGCTGGTGAAGGAGCTGCTGGAGAGGGA       GGGACTCACAGCTGCAGGGAAAATTGAGATCAAAATTGTCCGCCCATGGGCTGAAGGGACTGAAGAGG       GTGCACGTTGGCTGACTGATGAGGACACGAGAAACCTCAAGGAGATCTTCTTCAATATCTTGGTGCCG       GGAGCTGAAGAGGCCCAGAAGGAACGCCAGCGGCAGAAAGAGCTGGAGAGCAATTACCGCCGGGTGTG       GGGCTCTCCAGGTGGGGAGGGCACAGGGGACCTGGACGAATTTGACTTCTG&amp;GACCAACACTACACTT       GACCCTTCACGGAATCCAGACTCTTCCTGGACTGGCTTGCCTCCTCCCCACCTCCCCACCCTGGAACC       CCTGAGGGCCAAACAGCAGAGTGGAGCTGAGCTGTGGACCTCTCGGGCAACTCTGTGGGTGTGGGGGC       CCTGGGTGAATGCTGCTGCCCCTGCTGGCAGCCACCTTGAGACCTCACCGGGCCTGTGATATTTGCTC       TCCTGAACTCTCACTCAATCCTCTTCCTCTCCTCTGTGGCTTTTCCTGTTATTGTCCCCTAATGATAC       GATATTCCCTGCTGCCTACCTGGAGATTCAGTAGGATCTTTTGAGTGGAGGTGGGTAGAGAGAGCAAC       GAGGGCAGGACACTTAGCAGGCACTGAGCAAGCAGGCCCCCACCTGCCCTTAGTGATGTTTGGAGTCG       TTTTACCCTCTTCTATTGAATTGCCTTGGGATTTCCTTCTCCCTTTCCCTGCCCACCCTGTCCCCTAC       AATTTGTGCTTCTGAGTTGAGGAGCCTTCACCTCTGTTGCTGAGGAAATGGTAGAATGCTGCCTATCA       CCTCCAGCACAATCCCAGCGAAAAAGGTGTGAAGCACCCACCATGTTCTTGAACAATCAGGTTTCTAP       ATAAACAACTGGACCATCA                                         NOV41a, CG56878-01                                     Protein Sequence   SEQ ID NO: 950   668 aa   MW at 75659.9kD                             MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYK           QRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDS       EIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISG       DYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQAVDSKQYGDK       IIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEA       ADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDP       ERQREMEEEEDEDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKEL       DPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRV       RVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLT       DEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTGDLDEFDF                                             NOV41b, 175070399   SEQ ID NO: 951   1773 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             GGTACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCT           GCCGTTGCCTGTCATGGGAGGGCAGAGCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAAC       AGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTGAAAGGGAGGAGGAAACACCT       GCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTGCTGAAGAC       AAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAG       AGATCAAAGGTGAAGTCCTCTATCTCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCC       AAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTATGGCAATGGGTCCAAGTGCGA       CCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGTTCCTCTGTGACGAGGGTGCAGGTATCTCTGGGG       ACTACATCGATCGCGTGGACGAGCCCTTGTCCTGCTCTTATGTGCTGACCATTCGCACTCCTCGGCTC       TGCCCCCACCCTCTCCTCCGGCCCCCACCCAGTGCTGCACCGCAGGCCATCCTCTGTCACCCTTCCCT       ACAGCCTGAGGAGTACATGGCCTACGTTCAGAGGCAAGCCGACTCAAAGCAGTATGGAGATAAAATCA       TAGAGGAGCTGCAAGATCTAGGCCCCCAAGTGTGGAGTGAGACCAAGTCTGGGGTGGCACCCCAAAAG       ATGGCAGGTGCGAGCCCGACCAAGGATGACAGTAAGGACTCAGATTTCTGGAAGATGCTTAATGAGCC       AGAGGACCAGGCCCCAGGAGGGGAGGAGGTGCCGGCTGAGGAGCAGGACCCAAGCCCTGAGGCAGCAG       ATTCAGCTTCTGGTGCTCCCAATGATTTTCAGAACAACGTGCAGGTCAAAGTCATTCGAAGCCCTGCG       GATTTGATTCGATTCATAGAGGAGCTGAAAGGTGGAACAAAAAAGGGGAAGCCAAATATGGACCAAGA       GCAGCCTGTGGATGATGCTGCAGAAGTCCCTCAGAGGGAACCAGAGAAGGAAAGGGGTGATCCAGAAC       GGCAGAGAGAGATGGAAGAAGAGGAGGATGAGGATGAGGATGAGGATGAAGATGAGGATGAACGGCAG       TTACTGGGAGAATTTGAGAAGGAACTGGAAGGGATCCTGCTTCCGTCAGACCGAGACCGGCTCCGTTC       GGAGGTGAAGGCTGGCATGGAGCGGGAACTGGAGAACATCATCCAGGAGACAGAGAAAGAGCTGGACC       CAGATGGGCTGAAGAAGGAGTCAGAGCGGGATCGGGCAATGCTGGCTCTCACATCCACTCTCAACAAA       CCCATCAAAAGACTGGAGGAAAAACAGAGTCCAGAGCTGGTGAAGAAGCACAAGAAAAAGAGGGTTGT       CCCCAAAAAGCCTCCCCCATCACCCCAACCTACAGGGAAAATTGAGATCAAAATTGTCCGCCCATGGG       CTGAAGGGACTGAAGAGGGTGCACGTTGGCTGACTGATGAGGACACGAGAAACCTCAAGGAGATCTTC       TTCAATATCTTGGTGCCGGGAGCTGAAGAGGCCCAGAAGGAACGCCAGCGGCAGAAAGAGCTGGAGAG       CAATTACCGCCGGGTGTGGGGCTCTCCAGGTGGGGAGGGCACAGGGGACCTGGACGAATTTGACTTCG       TCGAC                                         NOV41b, 175070399                                     Protein Sequence   SEQ ID NO: 952   591 aa   MW at 67172.0kD                             GTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEETP           AYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETA       KASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRL       CPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKTIEELQDLGPQVWSETKSGVAPQK       MAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPA       DLIRFIEELKGGTKKGKPNMDQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDEDEDERQ       LLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLLNK       PIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIF       FNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTGDLDEFDFVD                                             NOV41c, 175070432   SEQ ID NO: 953   1788 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             TCAGAATTCGCCCTTGGTACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTA           TGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCAGAGCCAATCTTCGGACGTGGTGATTGTCT       CCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTGAAAGG       GAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCC       CTGCTTGCTGAAGACAAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACC       ACATGGAAGATTCAGAGATCAAAGGTGAAGTCCTCTATCTCGGCTACTACCAATCAGCCTTCGACTGG       GATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTATGGCAA       TGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGTTCCTCTGTGACGAGGGTG       CAGGTATCTCTGGGGACTACATCGATCGCGTGGACGAGCCCTTGTCCTGCTCTTATGTGCTGACCATT       CGCACTCCTCGGCTCTGCCCCCACCCTCTCCTCCGGCCCCCACCCAGTGCTGCACCGCAGGCCATCCT       ATGGAGATAAAATCATAGAGGAGCTGCAAGATCTAGGCCCCCAAGTGTGGAGTGAGACCAAGTCTGGG       GTGGCACCCCAAAAGATGGCAGGTGCGAGCCCGACCAAGGATGACAGTAAGGACTCAGATTTCTGGAA       GATGCTTAATGAGCCAGAGGACCAGGCCCCAGGAGGGGAGGAGGTGCCGGCTGAGGAGCAGGACCCAA       GCCCTGAGGCAGCAGATTCAGCTTCTGGTGCTCCCAATGATTTTCAGAACAACGTGCAGGTCAAAGTC       AAATATAGGCCAAGAGCAGCCTGTGGATGATGCTGCAGAAGTCCCTCAGAGGGAACCAGAGAAGGAAA       GGGGTGATCCAGAACGGCAGAGAGAGATGGAAGAAGAGGAGGATGAGGATGAGGATGAGGATGAAGAT       GAGGATGAACGGCAGTTACTGGGAGAATTTGAGAAGGAACTGGAAGGGATCCTGCTTCCGTCAGACCG       AGGCCGGCTCCGTTCGGAGGTGAAGGCTGGCATGGAGCGGGAACTGGAAAACATCATCCAGGAGACAG       AGAAAGAGCTGGACCCAGATGGGCTGAAGAAGGAGTCAGAGCGGGATCGGGCAATGCTGGCTCTCACA       TCCACTCTCAACAAACTCATCAAAAGACTGGAGGAAAAACAGAGTCCAGAGCTGGTGAAGAAGCACAA       GAAAAAGAGGGTTGTCCCCAAAAAGCCTCCCCCATCACCCCAACCTACAGGGAAAATTGAGATCAAAA       TTGTCCGCCCATGGGCTGAAGGGACTGAAGAGGGTGCACGTTGGCTGACTGATGAGGACACGAGAAAC       CTCAAGGAGATCTTCTTCAATATCTTGGTGCCGGGAGCTGAAGAGGCCCAGAAGGAACGCCAGCGGCA       GAAAGAGCTGGAGAGCAATTACCGCCGGGTGTGGGGCTCTCCAGGTGGGGAGGGCACAGGGGACCTGG       ACGAATTTGACTTCGTCGAC                                         NOV41c, 175070432                                     Protein Sequence   SEQ ID NO: 954   596 aa   MW at 67601.5kD                             SEFALGTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQRER           EEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDW       DDETAKASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTI       RTPRLCPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSG       VAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKV       IRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDED       EDERQLLGEFEKELEGILLPSDRGRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALT       STLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTGKIEIKIVRPWAEGTEEGARWLTDEDTRN       LKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTGDLDEFDFVD                                             NOV41d, 175070419   SEQ ID NO: 955   1773 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             GGTACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCT           GCCGTTGCCTGTCATGGGAGGGCAGAGCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAAC       AGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTGAAAGGGAGGAGGAAACACCT       GCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTGCTGAAGAC       AAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAG       AGATCAAAGGTGAAGTCCTCTATCTCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCC       AAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTATGGCAATGGGTCCAAGTGCGA       CCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGTTCCTCTGTGACGAGGGTGCAGGTATCTCTGGGG       ACTACATCGATCGCGTGGACGAGCCCTTGTCCTGCTCTTATGTGCTGACCATTCGCACTCCTCGGCTC       TGCCCCCACCCTCTCCTCCGGCCCCCACCCAGTGCTGCACCGCAGGCCATCCTCTGTCACCCTTCCCT       ACAGCCTGAGGAGTACATGGCCTACGTTCAGAGGCAAGCCGACTCAAAGCAGTATGGAGATAAAATCA       TAGAGGAGCTGCAAGATCTAGGCCCCCAAGTGTGGAGTGAGACCAAGTCTGGGGTGGCACCCCAAAAG       ATGGCAGGTGCGAGCCCGACCAAGGATGACAGTAAGGACTCAGATTTCTGGAAGATGCTTAATGAGCC       AGAGGACCAGGCCCCAGGAGGGGAGGAGGTGCCGGCTGAGGAGCAGGACCCAAGCCCTGAGGCAGCAG       ATTCAGCTTCTGGTGCTCCCAATGATTTTCAGAACAACGTGCAGGTCAAAGTCATTCGAAGCCCTGCG       GATTTGATTCGATTCATAGAGGAGCTGAAAGGTGGAATAAAAAAGGGGAAGCCAAATATAGGCCAAGA       GCAGCCTGTGGATGATGCTGCAGAAGTCCCTCAGAGGGAACCAGAGAAGGAAAGGGGTGATCCAGAAC       GGCAGAGAGAGATGGAAGAAGAGGAGGATGAGGATGAGGATGAGGATGAAGATGAGGATGAACGGCAG       TTACTGGGAGAATTTGAGAAGGAACTGGAAGGGATCCTGCTTCCGTCAGACCGAGACCGGCTCCGTTC       GGAGGTGAAGGCTGGCATGGAGCGGGAACTGGAAAACATCATCCAGGAGACAGAGAAAGAGCTGGACC       CAGATGGGCTGAAGAAGGAGTCAGAGCGGGATCGGGCAATGCTGGCTCTCACATCCACTCTCAACAAA       CTCATCAAAAGACTGGAGGAAAAACAGAGTCCAGAGCTGGTGAAGAAGCACAAGAAAAAGAGGGTTGT       CCCCAAAAAGCCTCCCCCATCACCCCAACCTACAGGGAAAATTGAGATCAAAATTGTCCGCCCATGGG       CTGAAGGGACTGAAGAGGGTGCACGTTGGCTGACTGATGAGGACACGAGAAACCTCAAGGAGATCTTC       TTCAATATCTTGGTGCCGGGAGCTGAAGAGGCCCAGAAGGAACGCCAGCGGCAGAAAGAGCTGGAGAG       CAATTACCGCCGGGTGTGGGGCTCTCCAGGTGGGGAGGGCACAGGGGACCTGGACGAATTTGACTTCG       TCGAC                                         NOV41d, 175070419                                     Protein Sequence   SEQ ID NO: 956   591 aa   MW at 67124.0kD                             GTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEETP           AYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETA       KASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRL       CPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQK       MAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPA       DLIRFIEELKGGIKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDEDEDERQ       LLGEFEKELEGILLPSDPDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNK       LIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIF       FNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTGDLDEFDFVD                                             NOV41e, 175070438   SEQ ID NO: 957   1938 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             GGTACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCT           GCCGTTGCCTGTCATGGGAGGGCAGAGCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAAC       AGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTGAAAGGGAGGAGGAAACACCT       GCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTGCTGAAGAC       AAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAG       AGATCAAAGGTGAAGTCCTCTATCTCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCC       AAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTATGGCAATGGGTCCAAGTGCGA       CCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGTTCCTCTGTGACGAGGGTGCAGGTATCTCTGGGG       ACTACATCGATCGCGTGGACGAGCCCTTGTCCTGCTCTTATGTGCTGACCATTCGCACTCCTCGGCTC       TGCCCCCACCCTCTCCTCCGGCCCCCACCCAGTGCTGCACCGCAGGCCATCCTCTGTCACCCTTCCCT       ACAGCCTGAGGAGTACATGGCCTACGTTCAGAGGCAAGCCGACTCAAAGCAGTATGGAGATAAAATCA       TAGAGGAGCTGCAAGATCTAGGCCCCCAAGTGTGGAGTGAGACCAAGTCTGGGGTGGCACCCCAAAAG       ATGGCAGGTGCGAGCCCGACCAAGGATGACAGTAAGGACTCAGATTTCTGGAAGATGCTTAATGAGCC       AGAGGACCAGGCCCCAGGAGGGGAGGAGGTGCCGGCTGAGGAGCAGGACCCAAGCCCTGAGGCAGCAG       ATTCAGCTTCTGGTGCTCCCAATGATTTTCAGAACAACGTGCAGGTCAAAGTCATTCGAAGCCCTGCG       GATTTGATTCGATTCATAGAGGAGCTGAAAGGTGGAACAAAAAAGGGGAAGCCAAATATAGGCCAAGA       GCAGCCTGTGGATGATGCTGCAGAAGTCCCTCAGAGGGAACCAGAGAAGGAAAGGGGTGATCCAGAAC       GGCAGAGAGAGATGGAAGAAGAGGAGGATGAGGATGAGGATGAGGATGAAGATGAGGATGAACGGCAG       TTACTGGGAGAATTTGAGAAGGAACTGGAAGGGATCCTGCTTCCGTCAGACCGAGACCGGCTCCGTTC       GGAGGTGAAGGCTGGCATGGAGCGGGAACTGGAGAACATCATCCAGGAGACAGAGAAAGAGCTGGACC       CAGATGGGCTGAAGAAGGAGTCAGAGCGGGATCGGGCAATGCTGGCTCTCACATCCACTCTCAACAAA       CTCATCAAAAGACTGGAGGAAAAACAGAGTCCAGAGCTGGTGAAGAAGCACAAGAAAAAGAGGGTTGT       CCCCAAAAAGCCTCCCCCATCACCCCAACCTACAGAGGAGGATCCTGAGCACAGAGTCCGGGTCCGGG       TCACCAAGCTCCGTCTCGGAGGCCCTAATCAGGATCTGACTGTCCTCGAGATGAAACGGGAAAACCCA       CAGCTGAAACAAATCGAGGGGCTGGTGAAGGAGCTGCTGGAGAGGGAGGGACTCACAGCTGCAGGGAA       AATTGAGATCAAAATTGTCCGCCCATGGGCTGAAGGGACTGAAGAGGGTGCACGTTGGCTGACTGATG       AGGACACGAGAAACCTCAAGGAGATCTTCTTCAATATCTTGGTGCCGGGAGCTGAAGAGGCCCAGAAG       GAACGCCAGCGGCAGAAAGAGCTGGAGAGCAATTACCGCCGGGTGTGGGGCTCTCCAGGTGGGGAGGG       CACAGGGGACCTGGACGAATTTGACTTCGTCGAC                                         NOV41e, 175070438                                     Protein Sequence   SEQ ID NO: 958   646 aa   MW at 73427.1kD                             GTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEETP           AYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETA       KASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRL       CPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQK       MAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPA       DLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDEDEDERQ       LLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNK       LIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENP       QLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQK       ERQRQKELESNYRRVWGSPGGEGTGDLDEFDFVD                                             NOV41f, 175070408   SEQ ID NO: 959   1938 bp                             DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                             GGTACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCT           AGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTGAAAGGGAGGAGGAAACACCT       GCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTGCTGAAGAC       AAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAG       AGATCAAAGGTGAAGTCCTCTATCTCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCC       AAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTATGGCAATGGGTCCAAGTGCGA       CCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGTTCCTCTGTGACGAGGGTGCAGGTATCTCTGGGG       ACTACATCGATCGCGTGGACGAGCCCTTGTCCTGCTCTTATGTGCTGACCATTCGCACTCCTCGGCTC       TGCCCCCACCCTCTCCTCCGGCCCCCACCCAGTGCTGCACCGCAGGCCATCCTCTGTCACCCTTCCCT       ACAGCCTGAGGAGTACATGGCCTACGTTCAGAGGCAAGCCGACTCAAAGCAGTATGGAGATAAAATCA       TAGAGGAGCTGCAAGATCTAGGCCCCCAAGTGTGGAGTGAGACCAAGTCTGGGGTGGCACCCCAAAAG       ATGGCAGGTGCGAGCCCGACCAAGGATGACAGTAAGGACTCAGATTTCTGGAAGATGCTTAATGAGCC       AGAGGACCAGGCCCCAGGAGGGGAGGAGGTGCCGGCTGAGGAGCAGGACCCAAGCCCTGAGGCAGCAG       ATTCAGCTTCTGGTGCTCCCAATGATTTTCAGAACAACGTGCAGGTCAAAGTCATTCGAAGCCCTGCG       GATTTGATTCGATTCATAGAGGAGCTGAAAGGTGGAACAAAAAAGGGGAAGCCAAATATAGGCCAAGA       GCAGCCTGTGGATGATGCTGCAGAAGTCCCTCAGAGGGAACCAGAGAAGGAAAGGGGTGATCCAGAAC       GGCAGAGAGAGATGGAAGAAGAGGAGGATGAGGATGAGGATGAGGATGAAGATGAGGATGAACGGCAG       TTACTGGGAGAATTTGAGAAGGAACTGGAAGGGATCCTGCTTCCGTCAGACCGAGACCGGCTCCGTTC       GGAGGTGAAGGCTGGCATGGAGCGGGAACTGGAAAACATCATCCAGGAGACAGAGAAAGAGCTGGACC       CAGATGGGCTGAAGAAGGAGTCAGAGCGGGATCGGGCAATGCTGGCTCTCACATCCACTCTCAACAAA       CTCATCAAAAGACTGGAGGAAAAACAGAGTCCAGAGCTGGTGAAGAAGCACAAGAAAAAGAGGGTTGT       CCCCAAAAAGCCTCCCCCATCACCCCAACCTACAGAGGAGGATCCTGAGCACAGAGTCCGGGTCCGGG       TCACCAAGCTCCGTCTCGGAGGCCCTAATCAGGATCTGACTGTCCTCGAGATGAAACGGGAAAACCCA       CAGCTGAAACAAATCGAGGGGCTGGTGAAGGAGCTGCTGGAGAGGGAGGGACTCACAGCTGCAGGGAA       AATTGAGATCAAAATTGTCCGCCCATGGGCTGAAGGGACTGAAGAGGGTGCACGTTGGCTGACTGATG       AGGACACGAGAAACCTCAAGGAGATCTTCTTCAATATCTTGGTGCCGGGAGCTGAAGAGGCCCAGAAG       GAACGCCAGCGGCAGAAAGAGCTGGAGAGCAATTACCGCCGGGTGTGGGGCTCTCCAGGTGGGGAGGG       CACAGGGGACCTGGACGAATTTGACTTCGTCGAC                                         NOV41f, 175070408                                     Protein Sequence   SEQ ID NO: 960   646 aa   MW at 73427.1kD                             GTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEETP           AYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETA       KASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRL       CPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQK       MAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPA       DLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDEDEDERQ       LLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNK       LIKRLEEKQSPELVKKHKKKRVTPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENP       QLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQK       ERQRQKELESNYRRVWGSPGGEGTGDLDEFDFVD                                             NOV41g, CG56878-02   SEQ ID NO: 961   1938 bp                             DNA Sequence   ORF Start: at 7   ORF Stop: at 1933                             GGTACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCT           GCCGTTGCCTGTCATGGGAGGGCAGAGCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAAC       AGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTGAAAGGGAGGAGGAAACACCT       GCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTGCTGAAGAC       AAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAG       AGATCAAAGGTGAAGTCCTCTATCTCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCC       AAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTATGGCAATGGGTCCAAGTGCGA       CCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGTTCCTCTGTGACGAGGGTGCAGGTATCTCTGGGG       ACTACATCGATCGCGTGGACGAGCCCTTGTCCTGCTCTTATGTGCTGACCATTCGCACTCCTCGGCTC       TGCCCCCACCCTCTCCTCCGGCCCCCACCCAGTGCTGCACCGCAGGCCATCCTCTGTCACCCTTCCCT       ACAGCCTGAGGAGTACATGGCCTACGTTCAGAGGCAAGCCGACTCAAAGCAGTATGGAGATAAAATCA       TAGAGGAGCTGCAAGATCTAGGCCCCCAAGTGTGGAGTGAGACCAAGTCTGGGGTGGCACCCCAAAAG       ATGGCAGGTGCGAGCCCGACCAAGGATGACAGTAAGGACTCAGATTTCTGGAAGATGCTTAATGAGCC       AGAGGACCAGGCCCCAGGAGGGGAGGAGGTGCCGGCTGAGGAGCAGGACCCAAGCCCTGAGGCAGCAG       ATTCAGCTTCTGGTGCTCCCAATGATTTTCAGAACAACGTGCAGGTCAAAGTCATTCGAAGCCCTGCG       GATTTGATTCGATTCATAGAGGAGCTGAAAGGTGGAACAAAAAAGGGGAAGCCAAATATAGGCCAAGA       GCAGCCTGTGGATGATGCTGCAGAAGTCCCTCAGAGGGAACCAGAGAAGGAAAGGGGTGATCCAGAAC       GGCAGAGAGAGATGGAAGAAGAGGAGGATGAGGATGAGGATGAGGATGAAGATGAGGATGAACGGCAG       TTACTGGGAGAATTTGAGAAGGAACTGGAAGGGATCCTGCTTCCGTCAGACCGAGACCGGCTCCGTTC       GGAGGTGAAGGCTGGCATGGAGCGGGAACTGGAGAACATCATCCAGGAGACAGAGAAAGAGCTGGACC       CAGATGGGCTGAAGAAGGAGTCAGAGCGGGATCGGGCAATGCTGGCTCTCACATCCACTCTCAACAAA       CTCATCAAAAGACTGGAGGAAAAACAGAGTCCAGAGCTGGTGAAGAAGCACAAGAAAAAGAGGGTTGT       CCCCAAAAAGCCTCCCCCATCACCCCAACCTACAGAGGAGGATCCTGAGCACAGAGTCCGGGTCCGGG       TCACCAAGCTCCGTCTCGGAGGCCCTAATCAGGATCTGACTGTCCTCGAGATGAAACGGGAAAACCCA       AATTGAGATCAAAATTGTCCGCCCATGGGCTGAAGGGACTGAAGAGGGTGCACGTTGGCTGACTGATG       AGGACACGAGAAACCTCAAGGAGATCTTCTTCAATATCTTGGTGCCGGGAGCTGAAGAGGCCCAGAAG       GAACGCCAGCGGCAGAAAGAGCTGGAGAGCAATTACCGCCGGGTGTGGGGCTCTCCAGGTGGGGAGGG       CACAGGGGACCTGGACGAATTTGACTTCGTCGAC                                         NOV41g, CG56878-02                                     Protein Sequence   SEQ ID NO: 962   642 aa   MW at 73054.8kD                             GGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEETPAY           QGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKA       SKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCP       HPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMA       GASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNINQVKVIRSPADL       IRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDEDEDERQLL       GEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLI       KRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQL       KQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKER       QRQKELESNYRRVWGSPGGEGTGDLDEFDF                                             NOV41h, CG56878-03   SEQ ID NO: 963   1773 bp                             DNA Sequence   ORF Start: at 7   ORF Stop: at 1768                             GGTACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCT           GCCGTTGCCTGTCATGGGAGGGCAGAGCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAAC       AGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTGAAAGGGAGGAGGAAACACCT       GCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTGCTGAAGAC       AAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAG       AGATCAAAGGTGAAGTCCTCTATCTCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCC       AAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTATGGCAATGGGTCCAAGTGCGA       CCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGTTCCTCTGTGACGAGGGTGCAGGTATCTCTGGGG       ACTACATCGATCGCGTGGACGAGCCCTTGTCCTGCTCTTATGTGCTGACCATTCGCACTCCTCGGCTC       TGCCCCCACCCTCTCCTCCGGCCCCCACCCAGTGCTGCACCGCAGGCCATCCTCTGTCACCCTTCCCT       ACAGCCTGAGGAGTACATGGCCTACGTTCAGAGGCAAGCCGACTCAAAGCAGTATGGAGATAAAATCA       TAGAGGAGCTGCAAGATCTAGGCCCCCAAGTGTGGAGTGAGACCAAGTCTGGGGTGGCACCCCAAAAG       ATGGCAGGTGCGAGCCCGACCAAGGATGACAGTAAGGACTCAGATTTCTGGAAGATGCTTAATGAGCC       AGAGGACCAGGCCCCAGGAGGGGAGGAGGTGCCGGCTGAGGAGCAGGACCCAAGCCCTGAGGCAGCAG       ATTCAGCTTCTGGTGCTCCCAATGATTTTCAGAACAACGTGCAGGTCAAAGTCATTCGAAGCCCTGCG       GATTTGATTCGATTCATAGAGGAGCTGAAAGGTGGAATAAAAAAGGGGAAGCCAAATATAGGCCAAGA       GCAGCCTGTGGATGATGCTGCAGAAGTCCCTCAGAGGGAACCAGAGAAGGAAAGGGGTGATCCAGAAC       GGCAGAGAGAGATGGAAGAAGAGGAGGATGAGGATGAGGATGAGGATGAAGATGAGGATGAACGGCAG       TTACTGGGAGAATTTGAGAAGGAACTGGAAGGGATCCTGCTTCCGTCAGACCGAGACCGGCTCCGTTC       GGAGGTGAAGGCTGGCATGGAGCGGGAACTGGAAAACATCATCCAGGAGACAGAGAAAGAGCTGGACC       CAGATGGGCTGAAGAAGGAGTCAGAGCGGGATCGGGCAATGCTGGCTCTCACATCCACTCTCAACAAA       CTCATCAAAAGACTGGAGGAAAAACAGAGTCCAGAGCTGGTGAAGAAGCACAAGAAAAAGAGGGTTGT       CCCCAAAAAGCCTCCCCCATCACCCCAACCTACAGGGAAAATTGAGATCAAAATTGTCCGCCCATGGG       CTGAAGGGACTGAAGAGGGTGCACGTTGGCTGACTGATGAGGACACGAGAAACCTCAAGGAGATCTTC       TTCAATATCTTGGTGCCGGGAGCTGAAGAGGCCCAGAAGGAACGCCAGCGGCAGAAAGAGCTGGAGAG       CAATTACCGCCGGGTGTGGGGCTCTCCAGGTGGGGAGGGCACAGGGGACCTGGACGAATTTGACTTCG       TCGAC                                         NOV41h, CG56878-03                                     Protein Sequence   SEQ ID NO: 964   587 aa   MW at 66751.6kD                             GGVGSLNLEELSEMRYGIETLPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEETPAY           QGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKA       SKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCP       HPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMA       GASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADL       IRFIEELKGGIKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDEDEDERQLL       GEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLI       KRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTGKIEIKIVRPWAEGTEEGARWLTDEDTHNLKEIFFN       ILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTGDLDEFDF                                             NOV41i, CG56878-04   SEQ ID NO: 965   2702 bp                             DNA Sequence   ORF Start: ATG at 86   ORF Stop: TGA at 2036                             TTGCACTCTCCCACACCCTTTTCTTTTCGTCCGCTCTTCGCTTATTTCTCCCGCCGTCTCCTCTGCAT           AAGAAGGGGAACGAAAGATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGA       CTCCTGTTACCCGCAAGTCTGACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCG       TTATGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCAGAGCCAATCTTCGGACGTGGTGATTG       TCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTGAA       AGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGC       TCCCTGCTTGCTGAAGACAAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAAT       ACCACATGGAAGATTCAGAGATCAAAGGTGAAGTCCTCTATCTCGGCTACTACCAATCAGCCTTCGAC       TGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTATGG       CAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGTTCCTCTGTGACGAGG       GTGCAGGTATCTCTGGGGACTACATCGATCGCGTGGACGAGCCCTTGTCCTGCTCTTATGTGCTGACC       CCTCTGTCACCCTTCCCTACAGCCTGAGGAGTACATGGCCTACGTTCAGAGGCAAGCCGACTCAAAGC       AGTATGGAGATAAAATCATAGAGGAGCTGCAAGATCTAGGCCCCCAAGTGTGGAGTGAGACCAAGTCT       GGGGTGGCACCCCAAAAGATGGCAGGTGCGAGCCCGACCAAGGATGACAGTAAGGACTCAGATTTCTG       GAAGATGCTTAATGAGCCAGAGGACCAGGCCCCAGGAGGGGAGGAGGTGCCGGCTGAGGAGCAGGACC       GTCATTCGAAGCCCTGCGGATTTGATTCGATTCATAGAGGAGCTGAAAGGTGGAACAAAAAAGGGGAA       GCCAAATATAGGCCAAGAGCAGCCTGTGGATGATGCTGCAGAAGTCCCTCAGAGGGAACCAGAGAAGG       AAAGGGGTGATCCAGAACGGCAGAGAGAGATGGAAGAAGAGGAGGATGAGGATGAGGATAAGATGAGG       ATGAACGGCAGTTACTGGGGAGAATTTGAGAAGGAACTGGAAGGGATCCTGCTTCCGTCAGACCGAGA       CCGGCTCCGTTCGGAGACAGAGAAAGAGCTGGACCCAGATGGGCTGAAGAAGGAGTCAGAGCGGGATC       GGGCAATGCTGGCTCTCACATCCACTCTCAACAAACTCATCAAAAGACTGGAGGAAAAACAGAGTCCA       GAGCTGGTGAAGAAGCACAAGAAAAAGAGGGTTGTCCCCAAAAAGCCTCCCCCATCACCCCAACCTAC       AGAGGAGGATCCTGAGCACAGAGTCCGGGTCCGGGTCACCAAGCTCCGTCTCGGAGGCCCTAATCAGG       ATCTGACTGTCCTCGAGATGAAACGGGAAAACCCACAGCTGAAACAAATCGAGGGGCTGGTGAAGGAG       CTGCTGGAGAGGGAGGGACTCACAGCTGCAGGGAAAATTGAGATCAAAATTGTCCGCCCATGGGCTGA       AGGGACTGAAGAGGGTGCACGTTGGCTGACTGATGAGGACACGAGAAACCTCAAGGAGATCTTCTTCA       ATATCTTGGTGCCGGGAGCTGAAGAGGCCCAGAAGGAACGCCAGCGGCAGAAAGAGCTGGAGAGCAAT       TACCGCCGGGTGTGGGGCTCTCCAGGTGGGGAGGGCACAGGGGACCTGGACGAATTTGACTTCTGAGA       CCAACACTACACTTGACCCTTCACGGAATCCAGACTCTTCCTGGACTGGCTTGCCTCCTCCCCACCTC       CCCACCCTGGAACCCCTGAGGGCCAAACAGCAGAGTGGAGCTGAGCTGTGGACCTCTCGGGCAACTCT       GTGGGTGTGGGGGCCCTGGGTGAATGCTGCTGCCCCTGCTGGCAGCCACCTTGAGACCTCACCGGGCC       TGTGATATTTGCTCTCCTGAACTCTCACTCAATCCTCTTCCTCTCCTCTGTGGCTTTTCCTGTTATTG       TCCCCTAATGATAGGATATTCCCTGCTGCCTACCTGGAGATTCAGTAGGATCTTTTGAGTGGAGGTGG       GTAGAGAGAGCAAGGAGGGCAGGACACTTAGCAGGCACTGAGCAAGCAGGCCCCCACCTGCCCTTAGT       GATGTTTGGAGTCGTTTTACCCTCTTCTATGGAATTGCCTGTGGATTCCTTCTCCCTTCCCTGCCCAC       CGTGTCCTACAATTGTGCTCTGAGTGAGAGCCTTCCTCTCTGCTAGGAAGGTTATGTGCCTTACTCCG       CAATCGGAAAGTTAGCCACGTTCTAATCGTTATACAAGGCTAAAAAAAATAAATATTTATACCCGTTT       TTCCCTGATTTATTTTTAAATATTATATTATTTTTAATATAATTTGTGGG                                         NOV41i, CG56878-04                                     Protein Sequence   SEQ ID NO: 966   650 aa   MW at 73601.9kD                             MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYK           QRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDS       EIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISG       DYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKI       IEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAA       DSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPE       RQREMEEEEDEDEDKMRMNGSYWGEFEKELEGILLPSDRDRLRSETEKELDPDGLKKESERDRAMLAL       TSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLE       MKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPG       AEEAQKERQRQKELESNYRRVWGSPGGEGTGDLDEFDF                                                 SEQ ID NO: 967   2739 bp                                 NOV41j, SNP13382511 of   ORF Start: ATG at 86   ORF Stop: TGA at 2090                             CG56878-01, DNA Sequence   SNP Pos: 2596   SNP Change: C to T                             TTGCACTCTCCCACACCCTTTTCTTTTCGTCCGCTCTTCGCTTATTTCTCCCGCCGTCTCCTCTGCAT           AAGAAGGGGAACGAAAGATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGA       CTCCTGTTACCCGCAAGTCTGACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCG       TTATGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCAGAGCCAATCTTCGGACGTGGTGATTG       TCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTGAA       AGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGC       TCCCTGCTTGCTGAAGACAAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAAT       ACCACATGGAAGATTCAGAGATCAAAGGTGAAGTCCTCTATCTCGGCTACTACCAATCAGCCTTCGAC       TGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTATGG       CAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGTTCCTCTGTGACGAGG       GTGCAGGTATCTCTGGGGACTACATCGATCGCGTGGACGAGCCCTTGTCCTGCTCTTATGTGCTGACC       ATTCGCACTCCTCGGCTCTGCCCCCACCCTCTCCTCCGGCCCCCACCCAGTGCTGCACCGCAGGCCAT       CCTCTGTCACCCTTCCCTACAGCCTGAGGAGTACATGGCCTACGTTCAGAGGCAAGCCGTAGACTCAA       AGCAGTATGGAGATAAAATCATAGAGGAGCTGCAAGATCTAGGCCCCCAAGTGTGGAGTGAGACCAAG       TCTGGGGTGGCACCCCAAAAGATGGCAGGTGCGAGCCCGACCAAGGATGACAGTAAGGACTCAGATTT       CTGGAAGATGCTTAATGAGCCAGAGGACCAGGCCCCAGGAGGGGAGGAGGTGCCGGCTGAGGAGCAGG       ACCCAAGCCCTGAGGCAGCAGATTCAGCTTCTGGTGCTCCCAATGATTTTCAGAACAACGTGCAGGTC       AAAGTCATTCGAAGCCCTGCGGATTTGATTCGATTCATAGAGGAGCTGAAAGGTGGAACAAAAAAGGG       GAAGCCAAATATAGGCCAAGAGCAGCCTGTGGATGATGCTGCAGAAGTCCCTCAGAGGGAACCAGAGA       AGGAAAGGGGTGATCCAGAACGGCAGAGAGAGATGGAAGAAGAGGAGGATGAGGATGAGGATGAGGAT       GAAGATGAGGATGAACGGCAGTTACTGGGAGAATTTGAGAAGGAACTGGAAGGGATCCTGCTTCCGTC       AGACCGAGACCGGCTCCGTTCGGAGGTGAAGGCTGGCATGGAGCGGGAACTGGAGAACATCATCCAGG       AGACAGAGAAAGAGCTGGACCCAGATGGGCTGAAGAAGGAGTCAGAGCGGGATCGGGCAATGCTGGCT       CTCACATCCACTCTCAACAAACTCATCAAAAGACTGGAGGAAAAACAGAGTCCAGAGCTGGTGAAGAA       GCACAAGAAAAAGAGGGTTGTCCCCAAAAAGCCTCCCCCATCACCCCAACCTACAGAGGAGGATCCTG       AGCACAGAGTCCGGGTCCGGGTCACCAAGCTCCGTCTCGGAGGCCCTAATCAGGATCTGACTGTCCTC       GAGATGAAACGGGAAAACCCACAGCTGAAACAAATCGAGGGGCTGGTGAAGGAGCTGCTGGAGAGGGA       GGGACTCACAGCTGCAGGGAAAATTGAGATCAAAATTGTCCGCCCATGGGCTGAAGGGACTGAAGAGG       GGAGCTGAAGAGGCCCAGAAGGAACGCCAGCGGCAGAAAGAGCTGGAGAGCAATTACCGCCGGGTGTG       GGGCTCTCCAGGTGGGGAGGGCACAGGGGACCTGGACGAATTTGACTTCTGAGACCAACACTACACTT       GACCCTTCACGGAATCCAGACTCTTCCTGGACTGGCTTGCCTCCTCCCCACCTCCCCACCCTGGAACC       CCTGAGGGCCAAACAGCAGAGTGGAGCTGAGCTGTGGACCTCTCGGGCAACTCTGTGGGTGTGGGGGC       CCTGGGTGAATGCTGCTGCCCCTGCTGGCAGCCACCTTGAGACCTCACCGGGCCTGTGATATTTGCTC       TCCTGAACTCTCACTCAATCCTCTTCCTCTCCTCTGTGGCTTTTCCTGTTATTGTCCCCTAATGATAC       GATATTCCCTGCTGCCTACCTGGAGATTCAGTAGGATCTTTTGAGTGGAGGTGGGTAGAGAGAGCAAG       GAGGGCAGGACACTTAGCAGGCACTGAGCAAGCAGGCCCCCACCTGCCCTTAGTGATGTTTGGAGTCG       TTTTACCCTCTTCTATTGAATTGCCTTGGGATTTCCTTCTCCCTTTCCCTGCCCACCCTGTCCCCTAC       AATTTGTGCTTTTGAGTTGAGGAGCCTTCACCTCTGTTGCTGAGGAAATGGTAGAATGCTGCCTATCA       CCTCCAGCACAATCCCAGCGACAAAGGTGTGAAGCACCCACCATGTTCTTGAACAATCAGGTTTCTAA       ATAAACAACTGGACCATCA                                                 NOV41j, SNP13382511 of           MW at 75659.9kD                                 CG56878-01   SEQ ID NO: 968   668 aa   SNP Change: no change                             MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYK           QRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDS       EIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISG       DYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQAVDSKQYGDK       IIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEA       ADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDP       ERQREMEEEEDEDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKEL       DPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRV       RVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLT       DEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTGDLDEFDF                                                 SEQ ID NO: 969   2739 bp                                 NOV41k, SNP13382506 of   ORF Start: ATG at 86   ORF Stop: TGA at 2090                             CG56878-01, DNA Sequence   SNP Pos: 2671   SNP Change: C to T                             TTGCACTCTCCCACACCCTTTTCTTTTCGTCCGCTCTTCGCTTATTTCTCCCGCCGTCTCCTCTGCAT           CTCCTGTTACCCGCAAGTCTGACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCG       TTATGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCAGAGCCAATCTTCGGACGTGGTGATTG       AGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGC       TCCCTGCTTGCTGAAGACAAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAAT       ACCACATGGAAGATTCAGAGATCAAAGGTGAAGTCCTCTATCTCGGCTACTACCAATCAGCCTTCGAC       TGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTATGG       CAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGTTCCTCTGTGACGAGG       GTGCAGGTATCTCTGGGGACTACATCGATCGCGTGGACGAGCCCTTGTCCTGCTCTTATGTGCTGACC       ATTCGCACTCCTCGGCTCTGCCCCCACCCTCTCCTCCGGCCCCCACCCAGTGCTGCACCGCAGGCCAT       CCTCTGTCACCCTTCCCTACAGCCTGAGGAGTACATGGCCTACGTTCAGAGGCAAGCCGTAGACTCAA       AGCAGTATGGAGATAAAATCATAGAGGAGCTGCAAGATCTAGGCCCCCAAGTGTGGAGTGAGACCAAG       TCTGGGGTGGCACCCCAAAAGATGGCAGGTGCGAGCCCGACCAAGGATGACAGTAAGGACTCAGATTT       CTGGAAGATGCTTAATGAGCCAGAGGACCAGGCCCCAGGAGGGGAGGAGGTGCCGGCTGAGGAGCAGG       ACCCAAGCCCTGAGGCAGCAGATTCAGCTTCTGGTGCTCCCAATGATTTTCAGAACAACGTGCAGGTC       AAAGTCATTCGAAGCCCTGCGGATTTGATTCGATTCATAGAGGAGCTGAAAGGTGGAACAAAAAAGGG       GAAGCCAAATATAGGCCAAGAGCAGCCTGTGGATGATGCTGCAGAAGTCCCTCAGAGGGAACCAGAGA       AGGAAAGGGGTGATCCAGAACGGCAGAGAGAGATGGAAGAAGAGGAGGATGAGGATGAGGATGAGGAT       GAAGATGAGGATGAACGGCAGTTACTGGGAGAATTTGAGAAGGAACTGGAAGGGATCCTGCTTCCGTC       AGACCGAGACCGGCTCCGTTCGGAGGTGAAGGCTGGCATGGAGCGGGAACTGGAGAACATCATCCAGG       AGACAGAGAAAGAGCTGGACCCAGATGGGCTGAAGAAGGAGTCAGAGCGGGATCGGGCAATGCTGGCT       CTCACATCCACTCTCAACAAACTCATCAAAAGACTGGAGGAAAAACAGAGTCCAGAGCTGGTGAAGAA       GCACAAGAAAAAGAGGGTTGTCCCCAAAAAGCCTCCCCCATCACCCCAACCTACAGAGGAGGATCCTG       AGCACAGAGTCCGGGTCCGGGTCACCAAGCTCCGTCTCGGAGGCCCTAATCAGGATCTGACTGTCCTC       GAGATGAAACGGGAAAACCCACAGCTGAAACAAATCGAGGGGCTGGTGAAGGAGCTGCTGGAGAGGGA       GGGACTCACAGCTGCAGGGAAAATTGAGATCAAAATTGTCCGCCCATGGGCTGAAGGGACTGAAGAGG       GTGCACGTTGGCTGACTGATGAGGACACGAGAAACCTCAAGGAGATCTTCTTCAATATCTTGGTGCCG       GGAGCTGAAGAGGCCCAGAAGGAACGCCAGCGGCAGAAAGAGCTGGAGAGCAATTACCGCCGGGTGTG       GGGCTCTCCAGGTGGGGAGGGCACAGGGGACCTGGACGAATTTGACTTCTG&amp;GACCAACACTACACTT       CCTGAGGGCCAAACAGCAGAGTGGAGCTGAGCTGTGGACCTCTCGGGCAACTCTGTGGGTGTGGGGGC       CCTGGGTGAATGCTGCTGCCCCTGCTGGCAGCCACCTTGAGACCTCACCGGGCCTGTGATATTTGCTC       TCCTGAACTCTCACTCAATCCTCTTCCTCTCCTCTGTGGCTTTTCCTGTTATTGTCCCCTAATGATAG       GATATTCCCTGCTGCCTACCTGGAGATTCAGTAGGATCTTTTGAGTGGAGGTGGGTAGAGAGAGCAAG       GAGGGCAGGACACTTAGCAGGCACTGAGCAAGCAGGCCCCCACCTGCCCTTAGTGATGTTTGGAGTCG       TTTTACCCTCTTCTATTGAATTGCCTTGGGATTTCCTTCTCCCTTTCCCTGCCCACCCTGTCCCCTAC       CCTCCAGCACAATCCCAGTGAAAAAGGTGTGAAGCACCCACCATGTTCTTGAACAATCAGGTTTCTAA       ATAAACAACTGGACCATCA                                                 NOV41k, SNP13382506 of           MW at 75659.9kD                                 CG56878-01, Protein Sequence   SEQ ID NO: 970   668 aa   SNP Change: no change                             MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYK           QRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDS       EIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISG       DYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQAVDSKQYGDK       IIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEA       ADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDP       ERQREMEEEEDEDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKEL       DPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRV       RVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLT       DEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTGDLDEFDF                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 41B.  
               TABLE 41B                       Comparison of the NOV41 protein sequences.                                                NOV41a   MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDV   (SEQ ID NO:950)                   NOV4lb   -------G----------------TGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDV   (SEQ ID NO:952)               NOV41c   --SEFALG----------------TGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDV   (SEQ ID NO:954)               NOV41d   -------G----------------TGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDV   (SEQ ID NO:956)               NOV41e   -------G----------------TGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDV   (SEQ ID NO:958)               NOV41f   -------G----------------TGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDV   (SEQ ID NO:960)               NOV41g   -------G------------------GVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDV   (SEQ ID NO:960)               NOV41h   -------G------------------GVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDV   (SEQ ID NO:962)               NOV41i   MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDV   (SEQ ID NO:964)               NOV41a   VIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTY   (SEQ ID NO:966)               NOV41b   VIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTY               NOV41c   VIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTY               NOV4ld   VIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTY               NOV41e   VIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMPDAPCLLKTKDWWTY               NOV41f   VIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTY               NOV41g   VIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMPDAPCLLKTKDWWTY               NOV41h   VIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTY               NOV41i   VIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTY               NOV41a   EFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK               NOV41b   EFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK               NOV41c   EFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK               NOV41d   EFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK               NOV41e   EFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK               NOV41f   EFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK               NOV41g   EFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK               NOV41h   EFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK               NOV41i   EFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSK               NOV41a   CDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAA               NOV41b   CDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAA               NOV41c   CDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAA               NOV41d   CDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAA               NOV41e   CDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAA               NOV41f   CDLNGRPREAIEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAA               NOV41g   CDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAA               NOV41h   CDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAA               NOV41i   CDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAA               NOV41a   PQAILCHPSLQPEEYMAYVQRQAVDSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGA               NOV41b   PQAILCHPSLQPEEYMAYVQRQAD-SKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGA               NOV41c   PQAILCHPSLQPEEYMAYVQRQAD-SKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGA               NOV41d   PQAILCHPSLQPEEYMAYVQRQAD-SKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGA               NOV41e   PQAILCHPSLQPEEYMAYVQRQAD-SKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGA               NOV41f   PQAILCHPSLQPEEYMAYVQRQAD-SKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGA               NOV41g   PQAILCHPSLQPEEYMAYVQRQAD-SKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGA               NOV41h   PQAILCHPSLQPEEYMAYVQRQAD-SKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGA               NOV41i   PQAILCHPSLQPEEYMAYVQRQAD-SKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGA               NOV41a   SPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVI               NOV41b   SPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVI               NOV41c   SPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVI               NOV41d   SPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVI               NOV41e   SPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVI               NOV41f   SPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVI               NOV41g   SPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVI               NOV41h   SPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVI               NOV41i   SPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVI               NOV41a   RSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDE               NOV41b   RSPADLIRFIEELKGGTKKGKPNMDQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDE               NOV41c   RSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDE               NOV41d   RSPADLIRFIEELKGGIKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDE               NOV41e   RSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDE               NOV41f   RSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDE               NOV41g   RSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDE               NOV41h   RSPADLIRFIEELKGGIKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDE               NOV41i   RSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDE               NOV4la   DEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDG               NOV41b   DEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDG               NOV41c   DEDEDEDEDERQLLGEFEKELEGILLPSDRGRLRSEVKAGMERELENIIQETEKELDPDG               NOV41d   DEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDG               NOV41e   DEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDG               NOV41f   DEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDG               NOV41g   DEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDG               NOV41h   DEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDG               NOV41i   DED--KMPMNGSYWGEFEKELEGILLPSDRDRLR-------S--------ETEKELDPDG               NOV41a   LKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEH               NOV41b   LKKESERDRAMLALTSTLNKPIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPT------               NOV41c   LKKESERDHAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPT------               NOV41d   LKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPT------               NOV41e   LKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEH               NOV41f   LKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEH               NOV41g   LKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEH               NOV41h   LKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPT------               NOV41i   LKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEH               NOV41a   RVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPW               NOV41b   -------------------------------------------------GKIEIKIVRPW               NOV41c   -------------------------------------------------GKIEIKIVRPW               NOV41d   -------------------------------------------------GKIEIKIVRPW               NOV41e   RVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPW               NOV41f   RVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPW               NOV41g   RVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPW               NOV41h   -------------------------------------------------GKIEIKIVRPW               NOV41i   RVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPW               NOV41a   AEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGT               NOV41b   AEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGT               NOV41c   AEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGT               NOV41d   AEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGT               NOV41e   AEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGT               NOV41f   AEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGT               NOV41g   AEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGT               NOV41h   AEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGT               NOV41i   AEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGT               NOV41a   GDLDEFDF--               NOV41b   GDLDEFDFVD               NOV41c   GDLDEFDFVD               NOV41d   GDLDEFDFVD               NOV41e   GDLDEFDFVD               NOV41f   GDLDEFDFVD               NOV41g   GDLDEFDF--               NOV41h   GDLDEFDF--               NOV41i   GDLDEFDF--                  
 
      Further analysis of the NOV41a protein yielded the following properties shown in Table 41C.  
               TABLE 41C                       Protein Sequence Properties NOV41a                                        SignalP analysis:   Cleavage site between residues 26 and 27       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 4; pos. chg 0; neg. chg 1           H-region:   length 29; peak value 0.00           PSG score:   −4.40                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 3.65           possible cleavage site: between 25 and 26                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 6-22               −6.74                             PERIPHERAL   Likelihood = 8.49 (at 48)                         ALOM score: −6.74 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 13           Charge difference: −3.0 C(−3.0)-N(0.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 2 (cytoplasmic tail 1 to 6)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   8.03           Hyd Moment(95):   5.55   G content:   5           D/E content:   2   S/T content:   6                         Score: −7.42       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: KKHK (3) at 515           pat4: KHKK (3) at 516           pat4: HKKK (3) at 517           pat4: KKKR (5) at 518           pat7: none           bipartite: KRLEEKQSPELVKKHKK at 503           content of basic residues: 13.6%           NLS Score: 1.06       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 76.7       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions       408 E   0.52       409 R   0.52       410 Q   0.52       411 R   0.52       412 E   0.52       413 M   0.74       414 E   0.97       415 E   0.97       416 E   0.97       417 E   0.97       418 D   0.97       419 E   0.97       420 D   0.97       421 E   0.97       422 D   0.97       423 E   0.97       424 D   0.97       425 E   0.97       426 D   0.97       427 E   0.97       428 D   0.97       429 E   0.97       430 R   0.97       431 Q   0.97       432 L   0.97       433 L   0.97       434 G   0.97       435 E   0.97       436 F   0.97       437 E   0.97       438 K   0.97       439 E   0.97       440 L   0.97       441 E   0.97       442 G   0.84       443 I   0.82           total: 36 residues                 Final Results (k = 9/23):                         43.5%: nuclear           26.1%: mitochondrial            8.7%: cytoplasmic            4.3%: extracellular, including cell wall            4.3%: Golgi            4.3%: plasma membrane            4.3%: vesicles of secretory system            4.3%: peroxisomal                 &gt;&gt; prediction for CG56878-01 is nuc (k = 23)                  
 
      A search of the NOV41a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 41D.  
               TABLE 41D                          Geneseq Results for NOV41a                                         NOV41a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value                                             ABP42584   Human ovarian antigen HOFNF76,   3 . . . 120   111/118   (94%)   8e−59           SEQ ID NO: 3716 -  Homo sapiens , 140   6 . . . 123   115/118   (97%)           aa. [WO200200677-A1 , 03-JAN-2002]       AAG76089   Human colon cancer antigen protein   508 . . . 668    100/161   (62%)   7e−45           SEQ ID NO: 6853 -  Homo sapiens , 106   1 . . . 106   102/161   (63%)           aa. [WO200122920-A2, 05-APR-2001]       ABP42294   Human ovarian antigen HNHBC18,   454 . . . 534    81/81   (100%)   5e−39           SEQ ID NO: 3426 -  Homo sapiens , 93   1 . . . 81    81/81   (100%)           aa. [WO200200677-A1, 03-JAN-2002]       AAG41826     Arabidopsis thaliana  protein fragment   19 . . . 265    83/263   (31%)   1e−24           SEQ ID NO: 52087 -  Arabidopsis     26 . . . 273    124/263   (46%)             thaliana , 282 aa. [EP1033405-A2,           06-SEP-2000]       AAG41828     Arabidopsis thaliana  protein fragment   100 . . . 265    61/169   (36%)   6e−23           SEQ ID NO: 52089 -  Arabidopsis     48 . . . 208    90/169   (53%)             thaliana , 217 aa. [EP1033405-A2,           06-SEP-2000]                  
 
      In a BLAST search of public sequence databases, the NOV41a protein was found to have homology to the proteins shown in the BLASTP data in Table 41E.  
               TABLE 41E                          Public BLASTP Results for NOV41a                                         NOV41a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q13438   Protein OS-9 precursor -  Homo     1 . . . 668   667/668 (99%)   0.0             sapiens  (Human), 667 aa.   1 . . . 667   667/668 (99%)       Q8IZ58   Hypothetical protein -  Homo sapiens     1 . . . 668   603/668 (90%)   0.0           (Human), 615 aa (fragment).   4 . . . 615   609/668 (90%)       Q9BW99   Similar to amplified in osteosarcoma -   1 . . . 668   603/668 (90%)   0.0             Homo sapiens  (Human), 612 aa.   1 . . . 612   609/668 (90%)       Q8K2C7   Hypothetical protein -  Mus musculus     1 . . . 668   489/676 (72%)   0.0           (Mouse), 617 aa.   1 . . . 617   544/676 (80%)       Q922S5   Unknown (Protein for   47 . . . 668    447/630 (70%)   0.0           IMAGE: 3598453) -  Mus musculus     1 . . . 571   501/630 (78%)           (Mouse), 571 aa (fragment).                  
 
      PFam analysis predicts that the NOV41a protein contains the domains shown in the Table 41F.  
               TABLE 41F                       Domain Analysis of NOV41a                                                Pfam Domain   NOV41a   Identities/   Expect           Match Region   Similarities   Value               for the               Matched Region                  
 
     Example 42  
      The NOV42 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 42A.  
               TABLE 42A                       NOV42 Sequence Analysis                                                NOV42a, CG56904-01   SEQ ID NO:971   1311 bp           DNA Sequence   ORF Start: ATG at 19   ORF Stop: TAA at 1282                       GGAGCTCCCACACTTTCA   ATG GGGAGGCCCACCCAGTGGCCGAGCCTGCTGCTGCTCCTGCTGTTGCC           GGGGCCCCCGCCCGTCGCCGGCTTGGAAGACGCTGCCTTCCCCCACCTGGGGGAGAGCTTGCAGCCCC       TGCCCCGGGCCTGTCCCCTGCGCTGCTCCTGCCCCCGAGTCGACACTGTGGACTGTGATGGCTTGGAC       CTTCGAGTGTTCCCGGACAACATCACCAGAGCCGCTCAGCACCTCTCCCTGCAGAACAACCAGCTCCA       GGAACTCCCCTACAATGAGCTGTCCCGCCTCAGTGGCCTGCGAACCCTCAACCTCCACAACAACCTCA       TCTCCTCCGAAGGCCTGCCTGACGAGGCCTTCGAGTCCCTCACCCAGCTGCAGCACCTCTGCGTGGCT       CACAACAAGAACAATCTCATCTCCAAGGTGCCCCGAGGAGCCCTGAGCCGCCAGACTCAACTCCGTGA       GCTCTACCTCCAGCACAACCAGCTGACAGACAGTGGCCTGGATGCCACCACCTTCAGCAAGCTGCATA       GCCTTGAATACCTGGATCTCTCCCACAACCAGCTGACCACAGTGCCCGCCGGCCTGCCCCGGACCCTG       GCTATCCTGCACCTGGGCCGCAACCGCATCCGGCAGGTGGAGGCGGCTCGGCTGCACGGGGCGCGTGG       TCTGCGCTATTTGTTGCTGCAGCACAACCAGCTGGGGAGCTCAGGGCTGCCCGCCGGGGCTCTGCGGC       CGCTGCGGGGCCTGCACACGCTGCACCTCGATGGCAATGGGCTGGACCGCGTGCCTCCAGCCCTGCCC       CGCCGCCTGCGTGCCCTGGTGCTGCCCCACAACCACGTGGCCGCGCTGGGTGCCCGTGACCTGGTCGC       CACACCGGGCCTGACGGAGCTTAACCTGGCCTATAACCGCCTGGCCAGCGCCCGTGTGCACCACCGGG       CCTTCCGCCGGTTGCGTGCCCTGCGCAGCCTCGACCTGGCAGGGAATCAGCTAACCCGGCTGCCCATG       GGCCTGCCCACTGGCCTGCGCACCCTGCAGCTGCAACGCAACCAGCTGCGGATGCTCGAGCCCGAGCC       TCTGGCCGGCCTGGACCAACTGCGGGAGCTCAGCCTGGCGCACAACCGGCTCCGGGTCGGCGACATCG       GGCCAGGCACCTGGCATGAGCTCCAAGCCCTCCAGGTCAGGCACAGGCTGGTTAGCCACACTGTCCCC       AGGGCCCCTCCATCCCCCTGCCTGCCCTGCCACGTCCCAAACATTCTAGTTAGCTGG TAA   AGCAATCA           GAACAAGAAAATGATAAGA                                                   NOV42a, CG56904-01   SEQ ID NO:972   421 aa   MW at 46667.3 kD               Protein Sequence                     MGRPTQWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDGLDLRVFPD           NITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKNNL       ISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLG       RNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLDGNGLDRVPPALPRRLRAL       VLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLPALRSLDLAGNQLTRLPMGLPTGL       RTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLVSHTVPRAPPSP       CLPCHVPNILVSW                                     NOV42b, 272355087   SEQ ID NO:973   1278 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GGATCCACCATGGGGAGGCCCACCCAGTGGCCGAGCCTGCTGCTGCTCCTGCTGTTGCCGGGGCCCCC           GCCCGTCGCCGGCTTGGAAGACGCTGCCTTCCCCCACCTGGGGGAGAGCTTGCAGCCCCTGCCCCGGG       CCTGTCCCCTGCGCTGCTCCTGCCCCCGAGTCGACACTGTGGACTGTGATGGCTTGGACCTTCGAGTG       TTCCCGGACAACATCACCAGAGCCGCTCAGCACCTCTCCCTGCAGAACAACCAGCTCCAGGAACTCCC       CTACAATGAGCTGTCCCGCCTCAGTGGCCTGCGAACCCTCAACCTCCACAACAACCTCATCTCCTCCG       AAGGCCTGCCTGACGAGGCCTTCGAGTCCCTCACCCAGCTGCAGCACCTCTGCGTGGCTCACAACAAG       AACAATCTCATCTCCAAGGTGCCCCGAGGAGCCCTGAGCCGCCAGACTCAACTCCGTGAGCTCTACCT       CCAGCACAACCAGCTGACAGACAGTGGCCTGGATGCCACCACCTTCAGCAAGCTGCATAGCCTTGAAT       ACCTGGATCTCTCCCACAACCAGCTGACCACAGTGCCCGCCGGCCTGCCCCGGACCCTGGCTATCCTG       CACCTGGGCCGCAACCGCATCCGGCAGGTGGAGGCGGCTCGGCTGCACGGGGCGCGTGGTCTGCGCTA       TTTGTTGCTGCAGCACAACCAGCTGGGGAGCTCAGGGCTGCCCGCCGGGGCTCTGCGGCCGCTGCGGG       GCCTGCACACGCTGCACCTCTATGGCAATGGGCTGGACCGCGTGCCTCCAGCCCTGCCCCGCCGCCTG       CGTGCCCTGGTGCTGCCCCACAACCACGTGGCCGCGCTGGGTGCCCGTGACCTGGTCGCCACACCGGG       CCTGACGGAGCTTAACCTGGCCTATAACCGCCTGGCCAGCGCCCGTGTGCACCACCGGGCCTTCCGCC       GGTTGCGTGCCCTGCGCAGCCTCGACCTGGCAGGGAATCAGCTAACCCGGCTGCCCATGGGCCTGCCC       ACTGGCCTGCGCACCCTGCAGCTGCAACGCAACCAGCTGCGGATGCTCGAGCCCGAGCCTCTGGCCGG       CCTGGACCAACTGCGGGAGCTCAGCCTGGCGCACAACCGGCTCCGGGTCGGCGACATCGGGCCAGGCA       CCTGGCATGAGCTCCAAGCCCTCCAGGTCAGGCACAGGCTGGTTAGCCACACTGTCCCCAGGGCCCCT       CCATCCCCCTGCCTGCCCTGCCACGTCCCAAACATTCTAGTTAGCTGGGAATTC                                                 NOV42b, 272355087   SEQ ID NO:974   426 aa   MW at 47236.9 kD               Protein Sequence                     GSTMGRPTQWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDGLDLRV           FPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNK       NNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAIL       HLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRL       RALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLP       TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLVSHTVPRAP       PSPCLPCHVPNILVSWEF                                     NOV42c, 246862506   SEQ ID NO:975   1122 bp           DNA Sequence   ORF Start: at 3   ORF Stop: at 1122                       GG ATCCACCATGGCTTGGACCTTCGAGTGTTCCCGGACAACATCACCAGAGCCGCTCAGCACCTCTCC           CTGCAGAACAACCAGCTCCAGGAACTCCCCTACAATGAGCTGTCCCGCCTCAGTGGCCTGCGAACCCT       CAACCTCCACAACAACCTCATCTCCTCCGAAGGCCTGCCTGACGAGGCCTTCGAGTCCCTCACCCAGC       TGCAGCACCTCTGCGTGGCTCACAACAAGAACAATCTCATCTCCAAGGTGCCCCGAGGAGCCCTGAGC       CGCCAGACTCAACTCCGTGAGCTCTACCTCCAGCACAACCAGCTGACAGACAGTGGCCTGGATGCCAC       CACCTTCAGCAAGCTGCATAGCCTTGAATACCTGGATCTCTCCCACAACCAGCTGACCACAGTGCCCG       CCGGCCTGCCCCGGACCCTGGCTATCCTGCACCTGGGCCGCAACCGCATCCGGCAGGTGGAGGCGGCT       CGGCTGCACGGGGCGCGTGGTCTGCGCTATTTGTTGCTGCAGCACAACCAGCTGGGGAGCTCAGGGCT       GCCCGCCGGGGCTCTGCGGCCGCTGCGGGGCCTGCACACGCTGCACCTCTATGGCAATGGGCTGGACC       GCGTGCCTCCAGCCCTGCCCCGCCGCCTGCGTGCCCTGGTGCTGCCCCACAACCACGTGGCCGCGCTG       GGTGCCCGTGACCTGGTCGCCACACCGGGCCTGACGGAGCTTAACCTGGCCTATAACCGCCTGGCCAG       CGCCCGTGTGCACCACCGGGCCTTCCGCCGGTTGCGTGCCCTGCGCAGCCTCGACCTGGCAGGGAATC       AGCTAACCCGGCTGCCCATGGGCCTGCCCACTGGCCTGCGCACCCTGCAGCTGCAACGCAACCAGCTG       CGGATGCTCGAGCCCGAGCCTCTGGCCGGCCTGGACCAACTGCGGGAGCTCAGCCTGGCGCACAACCG       GCTCCGGGTCGGCGACATCGGGCCAGGCACCTGGCATGAGCTCCAAGCCCTCCAGGTCAGGCACAGGC       TGGTTAGCCACACTGTCCCCAGGGCCCCTCCATCCCCCTGCCTGCCCTGCCACGTCCCAAACATTCTA       GTTAGCTGGGAATTCAAGGGCGAATTCCAAGCAC                                                 NOV42c, 246862506   SEQ ID NO:976   373 aa   MW at 41726.5 kD               Protein Sequence                     IHHGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQL           QHLCVAHNKNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPA       GLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDR       VPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQ       LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRL       VSHTVPRAPPSPCLPCHVPNILVSWEFKGEFQA                                     NOV42d, CG56904-04   SEQ ID NO:977   1977 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 1723                       ATG TGGCCGAGCCTGCTGCTGCTCCTGCTGTTGCCGGGGCCCCCGCCCGTCGCCGGCTTGGAAGACGC           TGCCTTCCCCCACCTGGGGGAGAGCTTGCAGCCCCTGCCCCGGGCCTGTCCCCTGCGCTGCTCCTGCC       CCCGAGTCGACACTGTGGACTGTGATGGCTTGGACCTTCGAGTGTTCCCGGACAACATCACCAGAGCC       GCTCAGCACCTCTCCCTGCAGAACAACCAGCTCCAGGAACTCCCCTACAATGAGCTGTCCCGCCTCAG       TGGCCTGCGAACCCTCAACCTCCACAACAACCTCATCTCCTCCGAAGGTCTGCCTGACGAGGCCTTCG       AGTCCCTCACCCAGCTGCAGCACCTCTGCGTGGCTCACAACAAGCTCTCAGTGGCCCCTCAGTTTCTG       CCCCGGTCCCTCCGTGTCGCGGATCTGGCTGCCAACCAAGTGATGGAGATCTTCCCCCTCACCTTTGG       GGAGAAGCCGGCACTCAGGTCCGTGTACCTCCACAACAACCAGCTGAGCAACGCTGGCCTGCCCCCCG       ACGCCTTCCGCGGCTCCGAGGCCATCGCCACCCTCAGCCTCTCCAACAACCAGCTCAGCTACCTGCCG       CCCAGCCTGCCGCCCTCACTCGAGCGGCTCCACCTGCAGAACAATCTCATCTCCAAGGTGCCCCGAGG       AGCCCTGAGCCGCCAGACTCAACTCCGTGAGCTCTACCTCCAGCACAACCAGCTGACAGACAGTGGCC       TGGATGCCACCACCTTCAGCAAGCTGCATAGCCTTGAATACCTGGATCTCTCCCACAACCAGCTGACC       ACAGTGCCCGCCGGCCTGCCCCGGACCCTGGCTATCCTGCACCTGGGCCGCAACCGCATCCGGCAGGT       GGAGGCGGCTCGGCTGCACGGGGCGCGTGGTCTGCGCTATTTGTTGCTGCAGCACAACCAGCTGGGGA       GCTCAGGGCTGCCCGCCGGGGCTCTGCGGCCGCTGCGGGGCCTGCACACGCTGCACCTCTATGGCAAT       GGGCTGGACCGCGTGCCTCCAGCCCTGCCCCGCCGCCTGCGTGCCCTGGTGCTGCCCCACAACCACGT       GGCCGCGCTGGGTGCCCGTGACCTGGTCGCCACACCGGGCCTGACGGAGCTTAACCTGGCCTATAACC       GCCTGGCCAGCGCCCGTGTGCACCACCGGGCCTTCCGCCGGTTGCGTGCCCTGCGCAGCCTCGACCTG       GCAGGGAATCAGCTAACCCGGCTGCCCATGGGCCTGCCCACTGGCCTGCGCACCCTGCAGCTGCAACG       CAACCAGCTGCGGATGCTCGAGCCCGAGCCTCTGGCCGGCCTGGACCAACTGCGGGAGCTCAGCCTGG       CGCACAACCGGCTCCGGGTCGGCGACATCGGGCCAGGCACCTGGCATGAGCTCCAAGCCCTCCAGATG       CTGGACCTCAGCCACAATGAGCTGTCCTTTGTGCCCCCGGACCTGCCTGAGGCCCTAGAGGAGCTGCA       CCTCGAGGGCAACCGCATCGGCCACGTGGGCCCCGAGGCCTTCCTCAGCACACCCCGCCTGCGTGCCC       TCTTCCTCAGGGCCAACAGGCTTCACATGACGAGCATCGCGGCTGAGGCCTTCCTGGGGCTCCCAAAC       CTGCGTGTGGTGGACACGGCAGGGAATCCGGAGCAGGTCCTGATCCGGCTGCCTCCCACCACCCCACG       TGGGCCACGGGCAGGGGGCCCC TGA   TCCTAGAGAGGCCCAGCAGAGCAGCTCAGACTCCTGGGACTCC           GCTGGGCCGTGGACTGAGGAGACAACGCCCACCAGGGGCCCTTGGTCTGGCTCTCCTGGGCCTCCAGG           GCTGGGCCTGCTCTGCCTGCCACTGGCCGAGACACAGAGGCACACAGCTGGCATACTCCAGGCTCACA           GACCACGCCGGCCTGGCGGGACACACCCTACCCCAAACTCCCAACACAGATGGAGGCAGCAACAATAA           AGCCA                                                   NOV42d, CG56904-04   SEQ ID NO:978   574 aa   MW at 63284.0 kD               Protein Sequence                     MWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRA           AQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFL       PRSLRVADTAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLP       PSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSNNQLT       TVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGN       GLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDL       AGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQM                                     NOV42e, 268824694   SEQ ID NO:979   1201 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCACCATGTGGCCGAGCCTGCTGCTGCTCCTGCTGTTGCCGGGGCCCCCGCCCGTCGCCG           GTTTGGAAGACGCTGCCTTCCCCCACCTGGGGGAGAGCTTGCAGCCCCTGCCCCGGGCCTGTCCCCTG       CGCTGCTCCTGCCCCCGAGTCGACACTGTGGACTGTGATGGCTTGGACCTTCGAGTGTTCCCGGACAA       CATCACCAGAGCCGCTCAGCACCTCTCCCTGCAGAACAACCAGCTCCAGGAACTCCCCTACAATGAGC       TGTCCCGCCTCAGTGGCCTGCGAACCCTCAACCTCCACAACAACCTCATCTCCTCCGAAGGCCTGCCT       GACGAGGCCTTCGAGTCCCTCACCCAGCTGCAGCACCTCTGCGTGGCTCACAACAAGCTCTCAGTGGC       CCCTCAGTTTCTGCCCCGGTCCCTCCGTGTCGCGGATCTGGCTGCCAACCAAGTGATGGAGATCTTCC       CCCTCACCTTTGGGGAGAAGCCGGCACTCAGGTCCGTGTACCTCCACAACAACCAGCTGAGCAACGCT       GGCCTGCCCCCCGACGCCTTCCGCGGCTCCGAGGCCATCGCCACCCTCAGCCTCTCCAACAACCAGCT       CAGCTACCTGCCGCCCAGCCTGCCGCCCTCACTCGAGCGGCTCCACCTGCAGAACAATCTCATCTCCA       AGGTGCCCCGAGGAGCCCTGAGCCGCCAGACTCAACTCCGTGAGCTCTACCTCCAGCACAACCAGCTG       ACAGACAGTGGCCTGGATGCCACCACCTTCAGCAAGCTGCATAGCCTTGAATACCTGGATCTCTCCCA       GCATCCGGCAGATGCTGGACCTCAGCCACAATGAGCTGTCCTTTGTGCCCCCGGACCTGCCTGAGGCC       CTAGAGGAGCTGCACCTCGAGGGCAACCGCATCGGCCACGTGGGCCCCGAGGCCTTCCTCAGCACACC       CCGCCTGCGTGCCCTCTTCCTCAGGGCCAACAGGCTTCACATGACGAGCATCGCGGCTGAGGCCTTCC       TGGGGCTCCCAAACCTGCGTGTGGTGGACACGGCAGGGAATCCGGAGCAGGTCCTGATCCGGCTGCCT       CCCACCACCCCACGTGGGCCACGGGCAGGGGGCCCCAAGCTTGGC                                                 NOV42e, 268824694   SEQ ID NO:980   400 aa   MW at 43934.7 kD               Protein Sequence                     TGSTMWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPPACPLRCSCPRVDTVDCDGLDLRVFPDN           ITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVA       PQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQL       SYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSH       NQLTTVPAGLPRTLAILHLGRNRIRQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVGPEAFLSTP       RLRALFLRANRLHMTSIAAEAFLGLPNLRVVDTAGNPEQVLIRLPPTTPRGPRAGGPKLG                                     NOV42f, 283146542   SEQ ID NO:981   1744 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCACCATGTGGCCGAGCCTGCTGCTGCTCCTGCTGTTGCCGGGGCCCCCGCCCGTCGCCG           GCTTGGAAGACGCTGCCTTCCCCCACCTGGGGGAGAGCTTGCAGCCCCTGCCCCGGGCCTGTCCCCTG       CGCTGCTCCTGCCCCCGAGTCGACACTGTGGACTGTGATGGCTTGGACCTTCGAGTGTTCCCGGACAA       CATCACCAGAGCCGCTCAGCACCTCTCCCTGCAGAACAACCAGCTCCAGGAACTCCCCTACAATGAGC       TGTCCCGCCTCAGTGGCCTGCGAACCCTCAACCTCCACAACAACCTCATCTCCTCCGAAGGCCTGCCT       GACGAGGCCTTCGAGTCCCTCACCCAGCTGCAGCACCTCTGCGTGGCTCACAACAAGCTCTCAGTGGC       CCCTCAGTTTCTGCCCCGGTCCCTCCGTGTCGCGGATCTGGCTGCCAACCAAGTGATGGAGATCTTCC       CCCTCACCTTTGGGGAGAAGCCGGCACTCAGGTCCGTGTACCTCCACAACAACCAGCTGAGCAACGCT       GGCCTGCCCCCCGACGCCTTCCGCGGCTCCGAGGCCATCGCCACCCTCAGCCTCTCCAACAACCAGCT       CAGCTACCTGCCGCCCAGCCTGCCGCCCTCACTCGAGCGGCTCCACCTGCAGAACAATCTCATCTCCA       AGGTGCCCCGAGGAGCCCTGAGCCGCCAGACTCAACTCCGTGAGCTCTACCTCCAGCACAACCAGCTG       ACAGACAGTGGCCTGGATGCCACCACCTTCAGCAAGCTGCATAGCCTTGAATACCTGGATCTCTCCCA       CAACCAGCTGACCACAGTGCCCGCCGGCCTGCCCCGGACCCTGGCTATCCTGCACCTGGGCCGCAACC       GCATCCGGCAGGTGGAGGCGGCTCGGCTGCACGGGGCGCGTGGTCTGCGCTATTTGTTGCTGCAGCAC       AACCAGCTGGGGAGCTCAGGGCTGCCCGCCGGGGCTCTGCGGCCGCTGCGGGGCCTGCACACGCTGCA       CCTCTATGGCAATGGGCTGGACCGCGTGCCTCCAGCCCTGCCCCGCCGCCTGCGTGCCCTGGTGCTGC       CCCACAACCACGTGGCCGCGCTGGGTGCCCGTGACCTGGTCGCCACACCGGGCCTGACGGAGCTTAAC       CTGGCCTATAACCGCCTGGCCAGCGCCCGTGTGCACCACCGGGCCTTCCGCCGGTTGCGTGCCCTGCG       CAGCCTCGACCTGGCAGGGAATCAGCTAACCCGGCTGCCCATGGGCCTGCCCACTGGCCTGCGCACCC       TGCAGCTGCAACGCAACCAGCTGCGGATGCTCGAGCCCGAGCCTCTGGCCGGCCTGGACCAACTGCGG       GAGCTCAGCCTGGCGCACAACCGGCTCCGGGTCGGCGACATCGGGCCAGGCACCTGGCATGAGCTCCA       AGCCCTCCAGATGCTGGACCTCAGCCACAATGAGCTGTCCTTTGTGCCCCCGGACCTGCCTGAGGCCC       TGGAGGAGCTGCACCTCGAGGGCAACCGCATCGGCCACGTGGGCCCCGAGGCCTTCCTCAGCACACCC       CGCCTGCGTGCCCTCTTCCTCAGGGCCAACAGGCTTCACATGACGAGCATCGCGGCTGAGGCCTTCCT       GGGGCTCCCAAACCTGCGTGTGGTGGACACGGCAGGGAATCCGGAGCAGGTCCTGATCCGGCTGCCTC       CCACCACCCCACGTGGGCCACGGGCAGGGGGCCCCAAGCTTGGC                                                 NOV42f, 283146542   SEQ ID NO:982   581 aa   MW at 63928.7 kD               Protein Sequence                     TGSTMWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDGLDLRVFPDN           ITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVA       PQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQL       SYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSH       NQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLH       LYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHEAFRRLRALR       SLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ       ALQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMTSIAAEAFL       IGLPNLRVVDTAGNPEQVLIRLPPTTPRGPRAGGPKLG                                     NOV42g, 308521214   SEQ ID NO:983   1744 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCACCATGTGGCCGAGCCTGCTGCTGCTCCTGCTGTTGCCGGGGCCCCCGCCCGTCGCCG           GCTTGGAAGACGCTGCCTTCCCCCACCTGGGGGAGAGCTTGCAGCCCCTGCCCCGGGCCTGTCCCCTG       CGCTGCTCCTGCCCCCGAGTCGACACTGTGGACTGTGATGGCTTGGACCTTCGAGTGTTCCCGGACAA       CATCACCAGAGCCGCTCAGCACCTCTCCCTGCAGAACAACCAGCTCCAGGAACTCCCCTACAATGAGC       TGTCCCGCCTCAGTGGCCTGCGAACCCTCAACCTCCACAACAACCTCATCTCCTCCGAAGGCCTGCCT       GACGAGGCCTTCGAGTCCCTCACCCAGCTGCAGCACCTCTGCGTGGCTCACAACAAGCTCTCAGTGGC       CCCTCAGTTTCTGCCCCGGTCCCTCCGTGTCGCGGATCTGGCTGCCAACCAAGTGATGGAGATCTTCC       CCCTCACCTTTGGGGAGAAGCCGGCACTCAGGTCCGTGTACCTCCACAACAACCAGCTGAGCAACGCT       GGCCTGCCCCCCGACGCCTTCCGCGGCTCCGAGGCCATCGCCACCCTCAGCCTCTCCAACAACCAGCT       CAGCTACCTGCCGCCCAGCCTGCCGCCCTCACTCGAGCGGCTCCACCTGCAGAACAATCTCATCTCCA       AGGTGCCCCGAGGAGCCCTGAGCCGCCAGACTCAACTCCGTGAGCTCTACCTCCAGCACAACCAGCTG       CAACCAGCTGACCACAGTGCCCGCCGGCCTGCCCCGGACCCTGGCTATCCTGCACCTGGGCCGCAACC       GCATCCGGCAGGTGGAGGCGGCTCGGCTGCACGGGGCGCGTGGTCTGCGCTATTTGTTGCTGCAGCAC       AACCAGCTGGGGAGCTCAGGGCTGCCCGCCGGGGCTCTGCGGCCGCTGCGGGGCCTGCACACGCTGCA       CCTCTATGGCAATGGGCTGGACCGCGTGCCTCCAGCCCTGCCCCGCCGCCTGCGTGCCCTGGTGCTGC       CCCACAACCACGTGGCCGCGCTGGGTGCCCGTGACCTGGTCGCCACACCGGGCCTGACGGAGCTTAAC       CTGGCCTATAACCGCCTGGCCAGCGCCCGTGTGCACCACCGGGCCTTCCGCCGGTTGCGTGCCCTGCG       CAGCCTCGACCTGGCAGGGAATCAGCTAACCCGGCTGCCCATGGGCCTGCCCACTGGCCTGCGCACCC       TGCAGCTGCAACGCAACCAGCTGCGGATGCTCGAGCCCGAGCCTCTGGCCGGCCTGGACCAACTGCGG       GAGCTCAGCCTGGCGCACAACCGGCTCCGGGTCGGCGACATCGGGCCAGGCACCTGGCATGAGCTCCA       AGCCCTCCAGATGCTGGACCTCAGCCACAATGAGCTGTCCTTTGTGCCCCCGGACCTGCCTGAGGCCC       TGGAGGAGCTGCACCTCGAGGGCAACCGCATCGGCCACGTGGGCCCCGAGGCCTTCCTCAGCACACCC       CGCCTGCGTGCCCTCTTCCTCAGGGCCAACAGGCTTCACATGACGAGCATCGCGGCTGAGGCCTTCCT       GGGGCTCCCAAACCTGCGTGTGGTGGACACGGCAGGGAATCCGGAGCAGGTCCTGATCCGGCTGCCTC       CCACCACCCCACGTGGGCCACGGGCAGGGGGCCCCGAATTCGGC                                                 NOV42g, 308521214   SEQ ID NO:984   581 aa   MW at 63963.7 kD               Protein Sequence                     TGSTMWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDGLDLRVFPDN           ITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVA       PQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQL       SYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSH       NQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLH       LYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALR       SLDLAGNQLTRLPMGLPTGLRTLQLQPNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ       ALQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMTSIAAEAFL       GLPNLRVVDTAGNPEQVLIRLPPTTPRGPRAGGPEFG                                     NOV42h, CG56904-02   SEQ ID NO:985   1506 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 1504                       ATG ATGAACAACCAGCTCCAGGAACTCCCCTACAATGAGCTGTCCCGCCTCAGTGGCCTGCGAACCCT           CAACCTCCACAACAACCTCATCTCCTCCGAAGGCCTGCCTGACGAGGCCTTCGAGTCCCTCACCCAGC       TGCAGCACCTCTGCGTGGCTCACAACAAGCTCTCAGTGGCCCCTCAGTTTCTGCCCCGGTCCCTCCGT       GTCGCGGATCTGGCTGCCAACCAAGTGATGGAGATCTTCCCCCTCACCTTTGGGGAGAAGCCGGCACT       CAGGTCCGTGTACCTCCACAACAACCAGCTGAGCAACGCTGGCCTGCCCCCCGACGCCTTCCGCGGCT       CCGAGGCCATCGCCACCCTCAGCCTCTCCAACAACCAGCTCAGCTACCTGCCGCCCAGCCTGCCGCCC       TCACTCGAGCGGCTCCACCTGCAGAACAATCTCATCTCCAAGGTGCCCCGAGGAGCCCTGAGCCGCCA       GACTCAACTCCGTGAGCTCTACCTCCAGCACAACCAGCTGACAGACAGTGGCCTGGATGCCACCACCT       CTGCCCCGGACCCTGGCTATCCTGCACCTGGGCCGCAACCGCATCCGGCAGGTGGAGGCGGCTCGGCT       GCACGGGGCGCGTGGTCTGCGCTATTTGTTGCTGCAGCACAACCAGCTGGGGAGCTCAGGGCTGCCCG       CCGGGGCTCTGCGGCCGCTGCGGGGCCTGCACACGCTGCACCTCTATGGCAATGGGCTGGACCGCGTG       CCTCCAGCCCTGCCCCGCCGCCTGCGTGCCCTGGTGCTGCCCCACAACCACGTGGCCGCGCTGGGTGC       CCGTGACCTGGTCGCCACACCGGGCCTGACGGAGCTTAACCTGGCCTATAACCGCCTGGCCAGCGCCC       GTGTGCACCACCGGGCCTTCCGCCGGTTGCGTGCCCTGCGCAGCCTCGACCTGGCAGGGAATCAGCTA       ACCCGGCTGCCCATGGGCCTGCCCACTGGCCTGCGCACCCTGCAGCTGCAACGCAACCAGCTGCGGAT       GCTCGAGCCCGAGCCTCTGGCCGGCCTGGACCAACTGCGGGAGCTCAGCCTGGCGCACAACCGGCTCC       GGGTCGGCGACATCGGGCCAGGCACCTGGCATGAGCTCCAAGCCCTCCAGATGCTGGACCTCAGCCAC       AATGAGCTGTCCTTTGTGCCCCCGGACCTGCCTGAGGCCCTAGAGGAGCTGCACCTCGAGGGCAACCG       CATCGGCCACGTGGGCCCCGAGGCCTTCCTCAGCACACCCCGCCTGCGTGCCCTCTTCCTCAGGGCCA       ACAGGCTTCACATGACGAGCATCGCGGCTGAGGCCTTCCTGGGGCTCCCAAACCTGCGTGTGGTGGAC       GGGCCCC TGA                                                   NOV42h, CG56904-02   SEQ ID NO:986   501 aa   MW at 55426.1 kD               Protein Sequence                     MMNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLR           VADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPP       SLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAG       LPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRV       PPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQL       TRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQMLDLSH       NELSFVPPDLPEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMTSIAAEAFLGLPNLRVVD       TAGNPEQVLIRLPPTTPRGPRAGGP                                     NOV42i, CG56904-03   SEQ ID NO:987   1239 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 1237                       ATG ATGAACAACCAGCTCCAGGAACTCCCCTACAATGAGCTGTCCCGCCTCAGTGGCCTGCGAACCCT           CAACCTCCACAACAACCTCATCTCCTCCGAAGGCCTGCCTGACGAGGCCTTCGAGTCCCTCACCCAGC       TGCAGCACCTCTGCGTGGCTCACAACAAGAACAATCTCATCTCCAAGGTGCCCCGAGGAGCCCTGAGC       CGCCAGACTCAACTCCGTGAGCTCTACCTCCAGCACAACCAGCTGACAGACAGTGGCCTGGATGCCAC       CACCTTCAGCAAGCTGCATAGCCTTGAATACCTGGATCTCTCCCACAACCAGCTGACCACAGTGCCCG       CCGGCCTGCCCCGGACCCTGGCTATCCTGCACCTGGGCCGCAACCGCATCCGGCAGGTGGAGGCGGCT       CGGCTGCACGGGGCGCGTGGTCTGCGCTATTTGTTGCTGCAGCACAACCAGCTGGGGAGCTCAGGGCT       GCCCGCCGGGGCTCTGCGGCCGCTGCGGGGCCTGCACACGCTGCACCTCTATGGCAATGGGCTGGACC       GCGTGCCTCCAGCCCTGCCCCGCCGCCTGCGTGCCCTGGTGCTGCCCCACAACCACGTGGCCGCGCTG       GGTGCCCGTGACCTGGTCGCCACACCGGGCCTGACGGAGCTTAACCTGGCCTATAACCGCCTGGCCAG       CGCCCGTGTGCACCACCGGGCCTTCCGCCGGTTGCGTGCCCTGCGCAGCCTCGACCTGGCAGGGAATC       AGCTAACCCGGCTGCCCATGGGCCTGCCCACTGGCCTGCGCACCCTGCAGCTGCAACGCAACCAGCTG       CGGATGCTCGAGCCCGAGCCTCTGGCCGGCCTGGACCAACTGCGGGAGCTCAGCCTGGCGCACAACCG       GCTCCGGGTCGGCGACATCGGGCCAGGCACCTGGCATGAGCTCCAAGCCCTCCAGATGCTGGACCTCA       GCCACAATGAGCTGTCCTTTGTGCCCCCGGACCTGCCTGAGGCCCTAGAGGAGCTGCACCTCGAGGGC       AACCGCATCGGCCACGTGGGCCCCGAGGCCTTCCTCAGCACACCCCGCCTGCGTGCCCTCTTCCTCAG       GGCCAACAGGCTTCACATGACGAGCATCGCGGCTGAGGCCTTCCTGGGGCTCCCAAACCTGCGTGTGG       TGGACACGGCAGGGAATCCGGAGCAGGTCCTGATCCGGCTGCCTCCCACCACCCCACGTGGGCCACGG       GCAGGGGGCCCC TGA                                                   NOV42i, CG56904-03   SEQ ID NO:988   412 aa   MW at 45723.1 kD               Protein Sequence                     MMNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKNNLISKVPRGALS           RQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAA       RLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAAL       GAPDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQL       RMLEPEPLAGLDQLRELSLAHKRLRVGDIGPGTWHELQALQMLDLSHNELSFVPPDLPEALEELHLEG       NRIGHVGPEAFLSTPRLRALFLRANRLHMTSIAAEAFLGLPNLRVVDTAGNPEQVLIRLPPTTPRGPR       AGGP                                     NOV42 , CG56904-05   SEQ ID NO:989   1710 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 1456                       ATG TGGCCGAGCCTGCTGCTGCTCCTGCTGTTGCCGGGGCCCCCGCCCGTCGCCGGCTTGGAAGACGC           TGCCTTCCCCCACCTGGGGGAGAGCTTGCAGCCCCTGCCCCGGGCCTGTCCCCTGCGCTGCTCCTGCC       CCCGAGTCGACACTGTGGACTGTGATGGCTTGGACCTTCGAGTGTTCCCGGACAACATCACCAGAGCC       GCTCAGCACCTCTCCCTGCAGAACAACCAGCTCCAGGAACTCCCCTACAATGAGCTGTCCCGCCTCAG       TGGCCTGCGAACCCTCAACCTCCACAACAACCTCATCTCCTCCGAAGGTCTGCCTGACGAGGCCTTCG       AGTCCCTCACCCAGCTGCAGCACCTCTGCGTGGCTCACAACAAGAACAATCTCATCTCCAAGGTGCCC       CGAGGAGCCCTGAGCCGCCAGACTCAACTCCGTGAGCTCTACCTCCAGCACAACCAGCTGACAGACAG       TGGCCTGGATGCCACCACCTTCAGCAAGCTGCATAGCCTTGAATACCTGGATCTCTCCCACAACCAGC       TGACCACAGTGCCCGCCGGCCTGCCCCGGACCCTGGCTATCCTGCACCTGGGCCGCAACCGCATCCGG       CAGGTGGAGGCGGCTCGGCTGCACGGGGCGCGTGGTCTGCGCTATTTGTTGCTGCAGCACAACCAGCT       GGGGAGCTCAGGGCTGCCCGCCGGGGCTCTGCGGCCGCTGCGGGGCCTGCACACGCTGCACCTCTATG       GCAATGGGCTGGACCGCGTGCCTCCAGCCCTGCCCCGCCGCCTGCGTGCCCTGGTGCTGCCCCACAAC       CACGTGGCCGCGCTGGGTGCCCGTGACCTGGTCGCCACACCGGGCCTGACGGAGCTTAACCTGGCCTA       TAACCGCCTGGCCAGCGCCCGTGTGCACCACCGGGCCTTCCGCCGGTTGCGTGCCCTGCGCAGCCTCG       ACCTGGCAGGGAATCAGCTAACCCGGCTGCCCATGGGCCTGCCCACTGGCCTGCGCACCCTGCAGCTG       CAACGCAACCAGCTGCGGATGCTCGAGCCCGAGCCTCTGGCCGGCCTGGACCAACTGCGGGAGCTCAG       CCTGGCGCACAACCGGCTCCGGGTCGGCGACATCGGGCCAGGCACCTGGCATGAGCTCCAAGCCCTCC       AGATGCTGGACCTCAGCCACAATGAGCTGTCCTTTGTGCCCCCGGACCTGCCTGAGGCCCTAGAGGAG       CTGCACCTCGAGGGCAACCGCATCGGCCACGTGGGCCCCGAGGCCTTCCTCAGCACACCCCGCCTGCG       TGCCCTCTTCCTCAGGGCCAACAGGCTTCACATGACGAGCATCGCGGCTGAGGCCTTCCTGGGGCTCC       CAAACCTGCGTGTGGTGGACACGGCAGGGAATCCGGAGCAGGTCCTGATCCGGCTGCCTCCCACCACC       CCACGTGGGCCACGGGCAGGGGGCCCC TGA   TCCTAGAGAGGCCCAGCAGAGCAGCTCAGACTCCTGGG           ACTCCGCTGGGCCGTGGACTGAGGAGACAACGCCCACCAGGGGCCCTTGGTCTGGCTCTCCTGGGCCT           CCAGGGCTGGGCCTGCTCTGCCTGCCACTGGCCGAGACACAGAGGCACACAGCTGGCATACTCCAGGC           TCACAGACCACGCCGGCCTGGCGGGACACACCCTACCCCAAACTCCCAACACAGATGGAGGCAGCAAC           AATAAAGCCA                                                   NOV42 , CG56904-05   SEQ ID NO:990   485aa   MW at 53581.10 kD               Protein Sequence                     MWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRA           AQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKNNLISKVP       RGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIR       QVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHN       HVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQL       QRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWJELQALQMLDLSHNELSFVPPDLPEALEE       LHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMTSIAAEAFLGLPNLRVVDTAGNPEQVLIRLPPTT       PRGPRAGGP                                     NOV42k, CG56904-06   SEQ ID NO:991   1992 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 1738                       ATG GGGAGGCCCACCCAGTGGCCGAGCCTGCTGCTGCTCCTGCTGTTGCCGGGGCCCCCGCCCGTCGC           CGGCTTGGAAGACGCTGCCTTCCCCCACCTGGGGGAGAGCTTGCAGCCCCTGCCCCGGGCCTGTCCCC       TGCGCTGCTCCTGCCCCCGAGTCGACACTGTGGACTGTGATGGCTTGGACCTTCGAGTGTTCCCGGAC       AACATCACCAGAGCCGCTCAGCACCTCTCCCTGCAGAACAACCAGCTCCAGGAACTCCCCTACAATGA       GCTGTCCCGCCTCAGTGGCCTGCGAACCCTCAACCTCCACAACAACCTCATCTCCTCCGAAGGTCTGC       CTGACGAGGCCTTCGAGTCCCTCACCCAGCTGCAGCACCTCTGCGTGGCTCACAACAAGCTCTCAGTG       GCCCCTCAGTTTCTGCCCCGGTCCCTCCGTGTCGCGGATCTGGCTGCCAACCAAGTGATGGAGATCTT       CCCCCTCACCTTTGGGGAGAAGCCGGCACTCAGGTCCGTGTACCTCCACAACAACCAGCTGAGCAACG       CTGGCCTGCCCCCCGACGCCTTCCGCGGCTCCGAGGCCATCGCCACCCTCAGCCTCTCCAACAACCAG       CTCAGCTACCTGCCGCCCAGCCTGCCGCCCTCACTCGAGCGGCTCCACCTGCAGAACAATCTCATCTC       CAAGGTGCCCCGAGGAGCCCTGAGCCGCCAGACTCAACTCCGTGAGCTCTACCTCCAGCACAACCAGC       TGACAGACAGTGGCCTGGATGCCACCACCTTCAGCAAGCTGCATAGCCTTGAATACCTGGATCTCTCC       CACAACCAGCTGACCACAGTGCCCGCCGGCCTGCCCCGGACCCTGGCTATCCTGCACCTGGGCCGCAA       CCGCATCCGGCAGGTGGAGGCGGCTCGGCTGCACGGGGCGCGTGGTCTGCGCTATTTGTTGCTGCAGC       ACAACCAGCTGGGGAGCTCAGGGCTGCCCGCCGGGGCTCTGCGGCCGCTGCGGGGCCTGCACACGCTG       CACCTCTATGGCAATGGGCTGGACCGCGTGCCTCCAGCCCTGCCCCGCCGCCTGCGTGCCCTGGTGCT       GCCCCACAACCACGTGGCCGCGCTGGGTGCCCGTGACCTGGTCGCCACACCGGGCCTGACGGAGCTTA       ACCTGGCCTATAACCGCCTGGCCAGCGCCCGTGTGCACCACCGGGCCTTCCGCCGGTTGCGTGCCCTG       CGCAGCCTCGACCTGGCAGGGAATCAGCTAACCCGGCTGCCCATGGGCCTGCCCACTGGCCTGCGCAC       CCTGCAGCTGCAACGCAACCAGCTGCGGATGCTCGAGCCCGAGCCTCTGGCCGGCCTGGACCAACTGC       GGGAGCTCAGCCTGGCGCACAACCGGCTCCGGGTCGGCGACATCGGGCCAGGCACCTGGCATGAGCTC       CAAGCCCTCCAGATGCTGGACCTCAGCCACAATGAGCTGTCCTTTGTGCCCCCGGACCTGCCTGAGGC       CCTAGAGGAGCTGCACCTCGAGGGCAACCGCATCGGCCACGTGGGCCCCGAGGCCTTCCTCAGCACAC       CCCGCCTGCGTGCCCTCTTCCTCAGGGCCAACAGGCTTCACATGACGAGCATCGCGGCTGAGGCCTTC       CTGGGGCTCCCAAACCTGCGTGTGGTGGACACGGCAGGGAATCCGGAGCAGGTCCTGATCCGGCTGCC       TCCCACCACCCCACGTGGGCCACGGGCAGGGGGCCCC TGA   TCCTAGAGAGGCCCAGCAGAGCAGCTCA           GACTCCTGGGACTCCGCTGGGCCGTGGACTGAGGAGACAACGCCCACCAGGGGCCCTTGGTCTGGCTC           TCCTGGGCCTCCAGGGCTGGGCCTGCTCTGCCTGCCACTGGCCGAGACACAGAGGCACACAGCTGGCA           TACTCCAGGCTCACAGACCACGCCGGCCTGGCGGGACACACCCTACCCCAAACTCCCAACACAGATGC           AGGCAGCAACAATAAAGCCA                                                   NOV42k, CG56904-06   SEQ ID NO:992   579 aa   MW at 63823.6 kD               Protein Sequence                     MGRPTQWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPPACPLRCSCPRVDTVDCDGLDLRVFPD           NITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV       APQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQ       LSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLS       HNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTL       HLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRAL       RSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHEL       QALQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMTSIAAEAF       LGLPNLRVVDTAGNPEQVLIRLPPTTPRGPRAGGP                                     NOV42l, CG56904-07   SEQ ID NO:993   1278 bp           DNA Sequence   ORF Start: ATG at 10   ORF Stop: at 1273                       GGATCCACC   ATG GGGAGGCCCACCCAGTGGCCGAGCCTGCTGCTGCTCCTGCTGTTGCCGGGGCCCCC           GCCCGTCGCCGGCTTGGAAGACGCTGCCTTCCCCCACCTGGGGGAGAGCTTGCAGCCCCTGCCCCGGG       CCTGTCCCCTGCGCTGCTCCTGCCCCCGAGTCGACACTGTGGACTGTGATGGCTTGGACCTTCGAGTG       TTCCCGGACAACATCACCAGAGCCGCTCAGCACCTCTCCCTGCAGAACAACCAGCTCCAGGAACTCCC       CTACAATGAGCTGTCCCGCCTCAGTGGCCTGCGAACCCTCAACCTCCACAACAACCTCATCTCCTCCG       AAGGCCTGCCTGACGAGGCCTTCGAGTCCCTCACCCAGCTGCAGCACCTCTGCGTGGCTCACAACAAG       AACAATCTCATCTCCAAGGTGCCCCGAGGAGCCCTGAGCCGCCAGACTCAACTCCGTGAGCTCTACCT       CCAGCACAACCAGCTGACAGACAGTGGCCTGGATGCCACCACCTTCAGCAAGCTGCATAGCCTTGAAT       CACCTGGGCCGCAACCGCATCCGGCAGGTGGAGGCGGCTCGGCTGCACGGGGCGCGTGGTCTGCGCTA       TTTGTTGCTGCAGCACAACCAGCTGGGGAGCTCAGGGCTGCCCGCCGGGGCTCTGCGGCCGCTGCGGG       GCCTGCACACGCTGCACCTCTATGGCAATGGGCTGGACCGCGTGCCTCCAGCCCTGCCCCGCCGCCTG       CGTGCCCTGGTGCTGCCCCACAACCACGTGGCCGCGCTGGGTGCCCGTGACCTGGTCGCCACACCGGG       CCTGACGGAGCTTAACCTGGCCTATAACCGCCTGGCCAGCGCCCGTGTGCACCACCGGGCCTTCCGCC       GGTTGCGTGCCCTGCGCAGCCTCGACCTGGCAGGGAATCAGCTAACCCGGCTGCCCATGGGCCTGCCC       ACTGGCCTGCGCACCCTGCAGCTGCAACGCAACCAGCTGCGGATGCTCGAGCCCGAGCCTCTGGCCGG       CCTGGACCAACTGCGGGAGCTCAGCCTGGCGCACAACCGGCTCCGGGTCGGCGACATCGGGCCAGGCA       CCTGGCATGAGCTCCAAGCCCTCCAGGTCAGGCACAGGCTGGTTAGCCACACTGTCCCCAGGGCCCCT       CCATCCCCCTGCCTGCCCTGCCACGTCCCAAACATTCTAGTTAGCTGGGAA TTC                                                   NOV421, CG56904-07   SEQ ID NO:994   421 aa   MW at 46715.4 kD               Protein Sequence                     MGRPTQWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDGLDLRVFPD           NITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKNNL       ISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLG       RNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRAL       VLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGL       RTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLVSHTVPRAPPSP       CLPCHVPNILVSW                                     NOV42m, CG56904-08   SEQ ID NO:995   1744 bp           DNA Sequence   ORF Start: ATG at 14   ORF Stop: end of sequence                       CACCGGATCCACC   ATG TGGCCGAGCCTGCTGCTGCTCCTGCTGTTGCCGGGGCCCCCGCCCGTCGCCG           GCTTGGAAGACGCTGCCTTCCCCCACCTGGGGGAGAGCTTGCAGCCCCTGCCCCGGGCCTGTCCCCTG       CGCTGCTCCTGCCCCCGAGTCGACACTGTGGACTGTGATGGCTTGGACCTTCGAGTGTTCCCGGACAA       CATCACCAGAGCCGCTCAGCACCTCTCCCTGCAGAACAACCAGCTCCAGGAACTCCCCTACAATGAGC       TGTCCCGCCTCAGTGGCCTGCGAACCCTCAACCTCCACAACAACCTCATCTCCTCCGAAGGCCTGCCT       GACGAGGCCTTCGAGTCCCTCACCCAGCTGCAGCACCTCTGCGTGGCTCACAACAAGCTCTCAGTGGC       CCCTCAGTTTCTGCCCCGGTCCCTCCGTGTCGCGGATCTGGCTGCCAACCAAGTGATGGAGATCTTCC       CCCTCACCTTTGGGGAGAAGCCGGCACTCAGGTCCGTGTACCTCCACAACAACCAGCTGAGCAACGCT       GGCCTGCCCCCCGACGCCTTCCGCGGCTCCGAGGCCATCGCCACCCTCAGCCTCTCCAACAACCAGCT       CAGCTACCTGCCGCCCAGCCTGCCGCCCTCACTCGAGCGGCTCCACCTGCAGAACAATCTCATCTCCA       AGGTGCCCCGAGGAGCCCTGAGCCGCCAGACTCAACTCCGTGAGCTCTACCTCCAGCACAACCAGCTG       ACAGACAGTGGCCTGGATGCCACCACCTTCAGCAAGCTGCATAGCCTTGAATACCTGGATCTCTCCCA       CAACCAGCTGACCACAGTGCCCGCCGGCCTGCCCCGGACCCTGGCTATCCTGCACCTGGGCCGCAACC       GCATCCGGCAGGTGGAGGCGGCTCGGCTGCACGGGGCGCGTGGTCTGCGCTATTTGTTGCTGCAGCAC       AACCAGCTGGGGAGCTCAGGGCTGCCCGCCGGGGCTCTGCGGCCGCTGCGGGGCCTGCACACGCTGCA       CCTCTATGGCAATGGGCTGGACCGCGTGCCTCCAGCCCTGCCCCGCCGCCTGCGTGCCCTGGTGCTGC       CCCACAACCACGTGGCCGCGCTGGGTGCCCGTGACCTGGTCGCCACACCGGGCCTGACGGAGCTTAAC       CTGGCCTATAACCGCCTGGCCAGCGCCCGTGTGCACCACCGGGCCTTCCGCCGGTTGCGTGCCCTGCG       CAGCCTCGACCTGGCAGGGAATCAGCTAACCCGGCTGCCCATGGGCCTGCCCACTGGCCTGCGCACCC       TGCAGCTGCAACGCAACCAGCTGCGGATGCTCGAGCCCGAGCCTCTGGCCGGCCTGGACCAACTGCGG       GAGCTCAGCCTGGCGCACAACCGGCTCCGGGTCGGCGACATCGGGCCAGGCACCTGGCATGAGCTCCA       AGCCCTCCAGATGCTGGACCTCAGCCACAATGAGCTGTCCTTTGTGCCCCCGGACCTGCCTGAGGCCC       TGGAGGAGCTGCACCTCGAGGGCAACCGCATCGGCCACGTGGGCCCCGAGGCCTTCCTCAGCACACCC       CGCCTGCGTGCCCTCTTCCTCAGGGCCAACAGGCTTCACATGACGAGCATCGCGGCTGAGGCCTTCCT       GGGGCTCCCAAACCTGCGTGTGGTGGACACGGCAGGGAATCCGGAGCAGGTCCTGATCCGGCTGCCTC       CCACCACCCCACGTGGGCCACGGGCAGGGGGCCCCAAGCTTGGC                                                 NOV42m, CG56904-08   SEQ ID NO:996   577 aa   MW at 63582.4 kD               Protein Sequence                     MWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRA           AQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFL       PRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLP       PSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLT       TVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGN       GLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDL       AGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQM       LDLSHNELSFVPPDLPEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMTSIAAEAFLGLPN       LRWDTAGNPEQVLIRLPPTTPRGPRAGGPKLG                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 42B.  
               TABLE 42B                       Comparison of the NOV42 protein sequences.                                                NOV42a   ---MGRPTQWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD   (SEQ ID NO:972)                   NOV42b   GSTMGRPTQWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD   (SEQ ID NO:974)               NOV42c   -----------------------------------------------------------I   (SEQ ID NO:976)               NOV42d   --------MWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD   (SEQ ID NO:978)               NOV42e   ----TGSTMWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD   (SEQ ID NO:980)               NOV42f   ----TGSTMWPSLLLLLLLPGPPPvAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD   (SEQ ID NO:982)               NOV42g   ----TGSTMWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD   (SEQ ID NO:984)               NOV42h   ------------------------------------------------------------   (SEQ ID NO:986)               NOV42i   ------------------------------------------------------------   (SEQ ID NO:988)               NOV42j   --------MWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD   (SEQ ID NO:990)               NOV42k   ---MGRPTQWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD   (SEQ ID NO:992)               NOV42l   ---MGRPTQWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD   (SEQ ID NO:994)               NOV42m   --------MWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD   (SEQ ID NO:996)               NOV42a   CDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEA               NOV42b   CDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEA               NOV42c   HHGLDLRVFPDNITPAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEA               NOV42d   CDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEA               NOV42e   CDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEA               NOV42f   CDGLDLRVFPDNITPAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEA               NOV42g   CDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEA               NOV42h   ---------------------MMNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEA               NOV42i   ---------------------MMNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEA               NOV42j   CDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEA               NOV42k   CDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEA               NOV42l   CDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEA               NOV42m   CDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEA               NOV42a   FESLTQLQHLCVAHNK--------------------------------------------               NOV42b   FESLTQLQHLCVAHNK--------------------------------------------               NOV42c   FESLTQLQHLCVAHNK--------------------------------------------               NOV42d   FESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNN               NOV42e   FESLTQLQHLCVAHNKLSVAPQFLPRSLR-------------------------------               NOV42f   FESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNN               NOV42g   FESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNN               NOV42h   FESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNN               NOV42i   FESLTQLQHLCVAHN---------------------------------------------               NOV42j   FESLTQLQHLCVAHNK--------------------------------------------               NOV42k   FESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNN               NOV42l   FESLTQLQHLCVAHNK--------------------------------------------               NOV42m   FESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNN               NOV42a   ---------------------------------------------NNLISKVPRGALSRQ               NOV42b   ---------------------------------------------NNLISKVPRGALSRQ               NOV42c   ---------------------------------------------NNLISKVPRGALSRQ               NOV42d   QLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQ               NOV42e   ----------------------------------------VADLAANQVMEIFPLTFGEK               NOV42f   QLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQ               NOV42g   QLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQ               NOV42h   QLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQ               NOV42i   ------------------------K--------------------NNLISKVPRGALSRQ               NOV42j   ---------------------------------------------NNLISKVPRGALSRQ               NOV42k   QLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQ               NOV42l   ---------------------------------------------NNLISKVPRGALSRQ               NOV42m   QLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQ               NOV42a   TQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRI               NOV42b   TQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRI               NOV42c   TQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRI               NOV42d   TQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRI               NOV42e   PALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLI               NOV42f   TQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRI               NOV42g   TQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRI               NOV42h   TQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGPNRI               NOV42i   TQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRI               NOV42j   TQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRI               NOV42k   TQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRI               NOV42l   TQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRI               NOV42m   TQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRI               NOV42a   RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLDGNGLDRVPPALPRR               NOV42b   RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR               NOV42c   RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR               NOV42d   RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR               NOV42e   SKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRT               NOV42f   RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR               NOV42g   RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR               NOV42h   RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR               NOV42i   RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR               NOV42j   RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR               NOV42k   RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR               NOV42l   RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR               NOV42m   RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR               NOV42a   LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQ               NOV42b   LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQ               NOV42c   LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLHALRSLDLAGNQ               NOV42d   LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQ               NOV42e   LAILHLGR---------------------------------------NRIRQMLDLSHNE               NOV42f   LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQ               NOV42g   LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQ               NOV42h   LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQ               NOV42i   LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFPRLRALRSLDLAGNQ               NOV42l   LRALVLFHNHVAALGARDLVATFGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQ               NOV42k   LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHEAFRRLRALRSLDLAGNQ               NOV421   LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLEALRSLDLAGNQ               NOV42m   LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHPAFRRLHALRSLDLAGNQ               NOV42a   LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ               NOV42b   LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGFGTWHELQ               NOV42c   LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ               NOV42d   LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ               NOV42e   LSFVPPDLPEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMTSIAAEAFLGLP               NOV42f   LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ               NOV42g   LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ               NOV42h   LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ               NOV42i   LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ               NOV42j   LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ               NOV42k   LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ               NOV42l   LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ               NOV42m   LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ               NOV42a   ALQVRHRLVSHT--VPRAPPSPCLPCHVPNILVSW-------------------------               NOV42b   ALQVRHRLVSHT--VPRAPPSPCLPCHVPNILVSWEF-----------------------               NOV42c   ALQVRHRLVSHT--VPRAPPSPCLPCHVPNILVSWEFKGEFQA-----------------               NOV42d   ALQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMT               NOV42e   NLRVVDTAGNPEQVLIRLPPTTPRGPRAGGPKLG--------------------------               NOV42f   ALQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMT               NOV42g   ALQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMT               NOV42h   ALQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMT               NOV42i   ALQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMT               NOV42j   ALQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMT               NOV42k   ALQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMT               NOV42l   ALQVRHRLVSHT--VPEAPPSPCLPCHVPNILVSW-------------------------               NOV42m   ALQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMT               NOV42a   ---------------------------------------------               NOV42c   ---------------------------------------------               NOV42d   SIAAEAFLGLPNLRVVDTAGNPEQVLIRLPPTTPRGPRAGGP---               NOV42e   ---------------------------------------------               NOV42f   SIAAEAFLGLPNLRVVDTAGNPEQVLIRLPPTTPRGPEAGGPKLG               NOV42g   SIAAEAFLGLPNLRVVDTAGNPEQVLIRLPPTTPRGPRAGGPEFG               NOV42h   SIAAEAFLGLPNLRVVDTAGNPEQVLIRLPPTTPRGPRAGGP---               NOV42i   SIAAEAFLGLPNLRVVDTAGNPEQVLIRLPPTTPRGPRAGGP---               NOV42j   SIAAEAFLGLPNLRVVDTAGNPEQVLIRLPPTTPRGPRAGGP---               NOV42k   SIAAEAFLGLPNLRVVDTAGNPEQVLIRLPPTTPRGPRAGGP---               NOV42l   ---------------------------------------------               NOV42m   SIAAEAFLGLPNLRVVDTAGNPEQVLIRLPPTTPRGPRAGGPKLG                  
 
      Further analysis of the NOV42a protein yielded the following properties shown in Table 42C.  
               TABLE 42C                       Protein Sequence Properties NOV42a                                        SignalP analysis:   Cleavage site between residues 25 and 26       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 3; pos. chg 1; neg. chg 0           H-region:   length 22; peak value 10.55           PSG score:   6.15                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 2.50           possible cleavage site: between 24 and 25                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 24)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 25           Tentative number of TMS(s) for the threshold 0.5: 0           number of TMS(s) . . . fixed                             PERIPHERAL   Likelihood = 4.77 (at 187)                         ALOM score: 4.77 (number of TMSs: 0)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 12           Charge difference: −4.5 C(−2.5)-N(2.0)           N &gt;= C: N-terminal side will be inside       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   1   Hyd Moment(75):   6.51           Hyd Moment(95):   8.64   G content:   3           D/E content:   1   S/T content:   2                         Score: −4.56       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 13 GRP|TQ                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: PRRLRAL (5) at 266           bipartite: none           content of basic residues: 10.7%           NLS Score: −0.04       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: GRPT                 none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs:                         Leucine zipper pattern (PS00029): *** found ***            LDLSHNQLTTVPAGLPRTLAIL at 180            LHLDGNGLDRVPPALPRRLRAL at 251            LDLAGNQLTRLPMGLPTGLRTL at 322                 none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear           discrimination           Prediction: nuclear           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         77.8%: extracellular, including cell wall           11.1%: vacuolar           11.1%: mitochondrial                 &gt;&gt; prediction for CG56904-01 is exc (k = 9)                  
 
      A search of the NOV42a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 42D.  
               TABLE 42D                          Geneseq Results for NOV42a                                         NOV42a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length [Patent #,   Match   the Matched   Expect       Identifier   Date]   Residues   Region   Value               AAU91336   Human novel secreted protein   7 . . . 421   414/415 (99%)   0.0           LP255(a) -  Homo sapiens , 423 aa.   9 . . . 423   414/415 (99%)           [WO200214358-A2, 21-FEB-2002]       AAU91340   Human novel secreted protein   7 . . . 421   413/459 (89%)   0.0           LP255(b) -  Homo sapiens , 467 aa.   9 . . . 467   413/459 (89%)           [WO200214358-A2, 21-FEB-2002]       AAG65893   Amino acid sequence of GSK gene Id   4 . . . 405   315/494 (63%)   e−153           90060 -  Homo sapiens , 605 aa.   30 . . . 523    336/494 (67%)           [WO200172961-A2, 04-OCT-2001]       AAG65892   Amino acid sequence of GSK gene Id   63 . . . 405    283/364 (77%)   e−152           90060 -  Homo sapiens , 483 aa.   38 . . . 401    300/364 (81%)           [WO200172961-A2, 04-OCT-2001]       ABU54399   Human secreted/transmembrane   39 . . . 392    178/443 (40%)   6e−79            protein PRO332 -  Homo sapiens , 642   92 . . . 534    232/443 (52%)           aa. [US2002132240-A1, 19-SEP-2002]                  
 
      In a BLAST search of public sequence databases, the NOV42a protein was found to have homology to the proteins shown in the BLASTP data in Table 42E.  
               TABLE 42E                          Public BLASTP Results for NOV42a                                         NOV42a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               CAD29040   Sequence 27 from Patent   7 . . . 421   414/415 (99%)   0.0           WO0214358 -  Homo sapiens     9 . . . 423   414/415 (99%)           (Human), 423 aa.       CAD29044   Sequence 35 from Patent   7 . . . 421   413/459 (89%)   0.0           WO0214358 -  Homo sapiens     9 . . . 467   413/459 (89%)           (Human), 467 aa.       Q9H5G9   Hypothetical protein FLJ23447 -   131 . . . 421    290/291 (99%)    e−166             Homo sapiens  (Human), 363 aa.   73 . . . 363    290/291 (99%)       Q8N641   Similar to hypothetical protein   131 . . . 392    141/262 (53%)   4e−70           FLJ23447 -  Homo sapiens  (Human),   33 . . . 294    175/262 (65%)           402 aa.       Q8BM45   Hypothetical leucine-rich   131 . . . 392    140/262 (53%)   5e−70           repeat/leucine-rich repeat -  Mus     33 . . . 294    176/262 (66%)             musculus  (Mouse), 399 aa.                  
 
      PFam analysis predicts that the NOV42a protein contains the domains shown in the Table 42F.  
               TABLE 42F                          Domain Analysis of NOV42a                                             Identities/               Pfam   NOV42a   Similarities for   Expect           Domain   Match Region   the Matched Region   Value                                                 LRRNT   43 . . . 71   11/35 (31%)   0.24                   22/35 (63%)           LRR    97 . . . 122   11/26 (42%)   0.0047                   23/26 (88%)           LRR   150 . . . 175   12/26 (46%)   0.056                   25/26 (96%)           LRR   176 . . . 195   11/25 (44%)   0.0079                   20/25 (80%)           LRR   221 . . . 246   10/26 (38%)   0.47                   22/26 (85%)           LRR   363 . . . 388   10/26 (38%)   0.46                   22/26 (85%)                      
 
     Example 43  
      The NOV43 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 43A.  
               TABLE 43A                       NOV43 Sequence Analysis                                                NOV43a, CG56914-01   SEQ ID NO:997   2153 bp           DNA Sequence   ORF Start: ATG at 16   ORF Stop: TAA at 2137                       GATGCTGGCACTTAC   ATG TGTGTGGCCCAGAACCCGGCTGGTACAGCCTTGGGCAAAATCAAGTTAAA           TGTCCAAGTTCCTCCAGTCATTAGCCCTCATCTAAAGGAATATGTTATTGCTGTGGACAAGCCCATCA       CGTTATCCTGTGAAGCAGATGGCCTCCCTCCGCCTGACATTACATGGCATAAAGATGGGCGTGCAATT       GTGGAATCTATCCGCCAGCGCGTCCTCAGCTCTGGCTCTCTGCAAATAGCATTTGTCCAGCCTGGTGA       TGCTGGCCATTACACGTGCATGGCAGCCAATGTAGCAGGATCAAGCAGCACAAGCACCAAGCTCACCG       TCCATGTACCACCCAGGATCAGAAGTACAGAAGGACACTACACGGTCAATGAGAATTCACAAGCCATT       CTTCCATGCGTAGCTGATGGAATCCCCACACCAGCAATTAACTGGAAAAAAGACAATGTTCTTTTAGC       TAACTTGTTAGGAAAATACACTGCTGAACCATATGGAGAACTCATTTTAGAAAATGTTGTGCTGGAGG       ATTCTGGCTTCTATACCTGTGTTGCTAACAATGCTGCAGGTGAAGATACACACACTGTCAGCCTGACT       GTGCATGTTCTCCCCACTTTTACTGAACTTCCTGGAGACGTGTCATTAAATAAAGGAGAACAGCTACG       ATTAAGCTGTAAAGCTACTGGTATTCCATTGCCCAAATTAACATGGACCTTCAATAACAATATTATTC       CAGCCCACTTTGACAGTGTGAATGGACACAGTGAACTTGTTATTGAAAGAGTGTCAAAAGAGGATTCA       GGTACTTATGTGTGCACCGCAGAGAACAGCGTTGGCTTTGTGAAGGCAATTGGATTTGTTTATGTGAA       AGAACCTCCAGTCTTCAAAGGTGATTATCCTTCTAACTGGATTGAACCACTTGGTGGGAATGCAATCC       TGAATTGTGAGGTGAAAGGAGACCCCACCCCAACCATCCAGTGGAACAGAAAGGGAGTGGATATTGAA       ATTAGCCACAGAATCCGGCAACTGGGCAATGGCTCCCTGGCCATCTATGGCACTGTTAATGAAGATGC       CGGTGACTATACATGTGTAGCTACCAATGAAGCTGGGGTGGTGGAGCGCAGCATGAGTCTGACTCTGC       AAAGTCCTCCTATTATCACTCTTGAGCCAGTGGAAACTGTTATTAATGCTGGTGGCAAAATCATATTG       AATTGTCAGGCAACTGGAGAGCCTCAACCAACCATTACATGGTCCCGTCAAGGGCACTCTATTTCCTG       GGATGACCGGGTTAACGTGTTGTCCAACAACTCATTATATATTGCTGATGCTCAGAAAGAAGATACCT       CTGAATTTGAATGCGTTGCTCGAAACTTAATGGGTTCTGTCCTTGTCAGAGTGCCAGTCATAGTCCAG       GTTCATGGTGGATTTTCCCAGTGGTCTGCATGGAGAGCCTGCAGTGTCACCTGTGGAAAAGGCATCCA       AAAGAGGAGTCGTCTGTGCAACCAGCCCCTTCCAGCCAATGGTGGGAAGCCCTGCCAAGGTTCAGATT       TGGAAATGCGAAACTGTCAAAATAAGCCTTGTCCAGTGGATGGTAGCTGGTCGGAATGGAGTCTTTGG       GAAGAATGCACAAGGAGCTGTGGACGCGGCAACCAAACCAGGACCAGGACTTGCAATAATCCATCAGT       TCAGCATGGTGGGCGGCCATGTGAAGGGAATGCTGTGGAAATAATTATGTGCAACATTAGGCCTTGCC       CAGTTCATGGAGCATGGAGCGCTTGGCAGCCTTGGGGAACATGCAGCGAAAGTTGTGGGAAAGGTACT       CAGACAAGAGCAAGACTTTGTAATAACCCACCACCAGCGTTTGGTGGGTCCTACTGTGATGGAGCAGA       AACACAGATGCAAGTTTGCAATGAAAGAAATTGTCCAATTCATGGCAAGTGGGCGACTTGGGCCAGTT       GGAGTGCCTGTTCTGTGTCATGTGGAGGAGGTGCCAGACAGAGAACAAGGGGCTGCTCCGACCCTGTG       CCCCAGTATGGAGGAAGGAAATGCGAAGGGAGTGATGTCCAGAGTGATTTTTGCAACAGTGACCCTTG       CCCAAGTGAGTGTTGGAAATACCCATGG TAA   CTGGAGTCCTTGGA                                                   NOV43a, CG56914-01   SEQ ID NO:998   707 aa   MW at 76557.7 kD               Protein Sequence                     MCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIR           QRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVA       DGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLP       TFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVC       TAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRI       RQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQAT       GEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGF       SQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVDGSWSEWSLWEECTR       SCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHGAWSAWQPWGTCSESCGKGTQTRAR       LCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGG       RKCEGSDVQSDFCNSDPCPSECWKYPW                                     NOV43b, 262802367   SEQ ID NO:999   2136 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GGATCCACCATGTGTGTGGCCCAGAACCCGGCTGGTACAGCCTTGGGCAAAATCAAGTTAAATGTCCA           AGTTCCTCCAGTCATTAGCCCTCATCTAAAGGAATATGTTATTGCTGTGGACAAGCCCATCACGTTAT       CCTGTGAAGCAGATGGCCTCCCTCCGCCTGACATTACATGGCATAAAGATGGGCGTGCAATTGTGGAA       TCTATCCGCCAGCGCGTCCTCAGCTCTGGCTCTCTGCAAATAGCATTTGTCCAGCCTGGTGATGCTGG       CCATTACACGTGCATGGCAGCCAATGTAGCAGGATCAAGCAGCACAAGCACCAAGCTCACCGTCCATG       TACCACCCAGGATCAGAAGTACAGAAGGACACTACACGGTCAATGAGAATTCACAAGCCATTCTTCCA       TGCGTAGCTGATGGAATCCCCACACCAGCAATTAACTGGAAAAAAGACAATGTTCTTTTAGCTAACTT       GTTAGGAAAATACACTGCTGAACCATATGGAGAACTCATTTTAGAAAATGTTGTGCTGGAGGATTCTG       GCTTCTATACCTGTGTTGCTAACAATGCTGCAGGTGAAGATACACACACTGTCAGCCTGACTGTGCAT       GTTCTCCCCACTTTTACTGAACTTCCTGGAGACGTGTCATTAAATAAAGGAGAACAGCTACGATTAAG       CTGTAAAGCTACTGGTATTCCATTGCCCAAATTAACATGGACCTTCAATAACAATATTATTCCAGCCC       ACTTTGACAGTGTGAATGGACACAGTGAACTTGTTATTGAAAGAGTGTCAAAAGAGGATTCAGGTACT       TATGTGTGCACCGCAGAGAACAGCGTTGGCTTTGTGAAGGCAATTGGATTTGTTTATGTGAAAGAACC       TCCAGTCTTCAAAGGTGATTATCCTTCTAACTGGATTGAACCACTTGGTGGGAATGCAATCCTGAATT       GTGAGGTGAAAGGAGACCCCACCCCAACCATCCAGTGGAACAGAAAGGGAGTGGATATTGAAATTAGC       CTATACATGTGTAGCTACCAATGAAGCTGGGGTGGTGGAGCGCAGCATGAGTCTGACTCTGCGAAGTC       CTCCTATTATCACTCTTGAGCCAGTGGAAACTGTTATTAATGCTGGTGGCAAAATCATATTGAATTGT       CAGGCAACTGGAGAGCCTCAACCAACTATTACATGGTCCCGTCAAGGGCACTCTATTTCCTGGGATGA       CCGGGTTAACGTGTTGTCCAACAACTCATTATATATTGCTGATGCTCAGAAAGAAGATACCTCTGAAT       TTGAATGTGTTGCTCGAAACTTAATGGGTTCTGTCCTTGTCAGAGTGCCAGTCATAGTCCAGGTTCAT       GGTGGATTTTCCCAGTGGTCTGCATGGAGAGCCTGCAGTGTCACCTGTGGAAAAGGCATCCAAAAGAG       TGCGAAACTGTCAAAATAAGCCTTGTCCAGTGGATGGTAGCTGGTCGGAATGGAGTCTTTGGGAAGAA       TGCACAAGGAGCTGTGGACGCGGCAACCAAACCAGGACCAGGACTTGCAATAATCCATCAGTTCAGCA       TGGTGGGCGGCCATGTGAAGGGAATGCTGTGGAAATAATTATGTGCAACATTAGGCCTTGCCCAGTTC       ATGGAGCATGGAGCGCTTGGCAGCTTTGGGGAACATGCAGCGAAAGTTGTGGGAAAGGTACTCAGACA       AGAGCAAGACTTTGTAATAACCCACCACCAGCGTTTGGTGGGTCCTACTGTGATGGAGCAGAAACACA       GATGCAAGTTTGCAATGAAAGAAATTGTCCAATTCATGGCAAGTGGGCGACTTGGGCCAGTTGGAGTG       CCTGTTCTGTGTCATGTGGAGGAGGTGCCAGACAGAGAACAAGGGGCTGCTCCGACCCTGTGCCCCAG       TATGGAGGAAGGAAATGCGAAGGGAGTGATGTCCAGAGTGATTTTTGCAACAGTGACCCTTGCCCAAG       TGAGTGTTGGAAATACCCATGGCTCGAG                                                 NOV43b, 262802367   SEQ ID NO:1000   712 aa   MW at 77089.2 kD               Protein Sequence                     GSTMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVE           SIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILP       CVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVH       VLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGT       YVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEIS       HRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLRSPPIITLEPVETVINAGGKIILNC       QATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVH       GGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVDGSWSEWSLWEE       CTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHGAWSAWQLWGTCSESCGKGTQT       RARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQ       YGGRKCEGSDVQSDFCNSDPCPSECWKYPWLE                                     NOV43c, CG56914-02   SEQ ID NO:1001   15660 bp           DNA Sequence   ORF Start: ATG at 1649   ORF Stop: TAA at 15134                       GATTAGTGGCATAAACTGTAGGTCAGCTGGTGGAGGCAAGCCAGCAAGGGGCTTCATGGTAACCAGTG               GAAACACAAAAATATAAQGGGCTTCTGAGGCGATCGGGCAGTGTCAGTCTTCAGCCGCTAAGCCGAGA           AGATCTGGGAAGGAGTCAGTCAGAGAGCCTTGGGCCAGAGTTCCAGGGGCTCTGGGAGTGGCTGCCAG           AAAATACCAGAAAATGAAAGGAATTGAAATTAAGAGAAGGGAGAGATTGAAGTGTGGCGCCAAGATTG           AAAGGAGAAAGAGGTTGAAGGATAGGGAGGTTGGAGAAGAGAGTAAAAAGAGGCCACTTACTGGATTT           GAAATTGAACCACCCAAAGTCACTGTGATGCCCAAGAATCAGTCTTTCACAGGAGGGTCTGAGGTCTC           CATCATGTGTTCTGCAACAGGTTATCCCAAACCAAAGATTGCCTGGACCGTTAACGATATGTTTATCG           TGGGTTCACACAGGTATAGGATGACCTCAGATGGTACCTTATTTATCAAAAATGCAGCTCCCAAAGAT           GCAGGGATCTATGGTTGCCTAGCAAAAGCCCCTAAGTTGATGGTAGTTCAGAGTGAGCTCTTGGTTGC           CCTTGGGGATATAACCGTTATGGAATGCAAAACCTCTGGTATTCCTCCACCTCAAGTTAAATGGTTCA           AAGGAGATCTTGAGTTGAGGCCCTCAACATTCCTCATTATTGACCCTCTCTTGGGACTTTTGAAGATT           CAAGAAACACAAGATCTGGATGCTGGCGATTATACCTGTGTAGCCATCAATGAGGCTGGAAGAGCAAC           AAATTGGCTCAAATGTGACATTACCTTGTTATGTTCAGGGTTATCCAGAACCAACAATCAAATGGCGA           AGATTAGACAACATGCCAATTTTCTCAAGACCTTTTTCAGTTAGTTCCATCAGCCAACTAAGAACAGG           AGCTCTCTTTATTTTAAACTTATGGGCAAGTGATAAAGGAACCTATATTTGTGAAGCTGAAAACCAGT           TTGGAAAGATCCAGTCAGAGACAACAGTAACAGTGACCGGACTTGTTGCTCCACTTATTGGAATCAGC           CCTTCAGTGGCCAATGTTATTGAAGGACAGCAGCTTACTTTGCCCTGTACTCTGTTAGCTGGAAATCC           CATTCCAGAACGTCGGTGGATTAAGAATTCAGCTATGTTGCTCCAAAATCCTTACATCACTGTGCGCA           GTGATGGGAGCCTCCATATTGAAAGAGTTCAGCTTCAGGATGGTGGTGAATATACTTGTGTGGCCAGT           AACGTTGCTGGGACCAATAACAAAACTACCTCTGTGGTTGTGCATGTTCTGCCAACCATTCAGCATGG           GCAGCAGATACTCAGTACAATTGAAGGCATTCCAGTAACTTTACCATGCAAAGCAAGTGGAAATCCCA           AACCGTCTGTCATCTGGTCCAAGGTAAATGATACATCTAGTTATATTTCCTGAAGAGCAGAGTGTGAA           GTTCACCTGCAAGTTATCCCTAGTCTTGAGCAGGAGGCTCAGGAGTGGGGCATGGAAAGAAGATAAGT           TAATAAAGGATTTCCT   ATG TGGCTGGACAGATGTGCTAGGAACCCTCCAAGAAACCATATAGATGCAC       CTCAGAAGGCTCCCTCGGCTTTTCGCCGTGTTTTGCAGAAAGGAGAGCTGATTTCAACCAGCAGTGCT       AAGTTTTCAGCAGGAGCTGATGGTAGTCTGTATGTGGTATCACCTGGAGGAGAGGAGAGTGGGGAGTA       TGTCTGCACTGCCACCAATACAGCCGGCTACGCCAAAAGGAAAGTGCAGCTAACAGTCTATGTAAGGC       CCAGAGTGTTTGGAGATCAACGAGGACTGTCCCAGGATAAGCCTGTTGAGATCTCCGTCCTTGCAGGG       GAAGAGGTAACACTTCCATGTGAAGTGAAGAGCTTACCTCCACCCATAATTACTTGGGCCAAAGAAAC       CCAGCTCATCTCACCGTTCTCTCCAAGACACACATTCCTCCCTTCTGGTTCAATGAAGATCACTGAAA       CCCGCACTTCAGATAGTGGGATGTATCTTTGTGTTGCCACAAATATTGCTGGGAATGTGACTCAGGCT       GTCAAATTAAATGTCCATGTTCCTCCAAAGATACAGCGTGGACCTAAACATCTCAAAGTCCAAGTTGG       TCAAAGAGTGGATATTCCATGTAATGCTCAAGGGACTCCTCTTCCTGTAATCACCTGGTCCAAAGGTG       GAAGCACTATGCTGGTTGATGGAGAGCACCATGTTAGCAATCCAGACGGAACTTTAAGCATCGACCAA       GATAACGCTACATGTCCAAGAACCACCCACAGTGGAAGATCTAGAACCTCCATATAACACTACTTTCC       AAGAAAGAGTGGCCAATCAACGCATTGAATTTCCATGTCCTGCAAAAGGTACCCCTAAACCAACCATC       AAATGGTTACACAATGGTAGAGAGTTGACAGGCAGAGAGCCTGGCATTTCTATCTTGGAAGATGGCAC       ATTGCTGGTTATTGCTTCTGTTACACCCTATGACAATGGGGAGTACATCTGTGTGGCAGTCAATGAAG       CTGGAACCACAGAAAGAAAATATAACCTCAAAGTCCATGTTCCTCCAGTAATTAAAGATAAAGAACAA       GTTACAAATGTGTCGGTGTTGTTAAATCAGCTGACCAATCTCTTCTGTGAAGTGGAAGGCACTCCATC       TCCCATCATTATGTGGTATAAAGATAATGTCCAGGTGACTGAAAGCAGCACTATTCAGACTGTGAACA       ATGGGAAGATACTGAAGCTCTTCAGAGCCACTCCAGAGGATGCAGGAAGATATTCCTGCAAAGCAATT       AATATTGCAGGCACTTCTCAGAAGTACTTTAACATTGATGTGCTAGGTACCAACTTCCCAAATGAAGT       CTCAGTTGTCCTCAACCGTGACGTCGCCCTTGAATGCCAGGTCAAAGGCACTCCCTTTCCTGATATTC       ATTGGTTCAAAGATGGCAATATTAAAGGAGGAAATGTCACCACAGACATATCAGTATTGATCAACAGC       CTTATTAAACTGGAATGTGAAACACGGGGACTTCCAATGCCTGCCATTACTTGGTATAAGGACGGGCA       GCCAATCATGTCCAGCTCACAAGCACTTTATATTGATAAAGGACAATATCTTCATATTCCTCGAGCAC               AGGTCTCTGATTCAGCAACATATACGTGTCACGTAGCCAATGTTGCTGGAACTGCTGAAAAATCATTC       CATGTGGATGTCTATGTTCCTCCAATGATTCAAGGCAACTTGGCCACGCCTTTGAATAAGCAAGTAGT       TATTGCTCATTCTCTGACACTGGAGTGCAAAGCTGCTGGAAACCCTTCTCCCATTCTCACCTGGTTGA       AAGATGGTGTACCTGTGAAAGCTAATGACAATATCCGCATAGAAGCTGGTGGGAAGAAACTCGAAATC       ATGAGTGCCCAAGAAATTGATCGAGGACAGTACATATGCGTGGCTACCAGTGTGGCAGGAGAAAAGGA       AATCAAATATGAAGTTGATGTCTTGGTGCCACCAGCTATAGAAGGAGGAGATGAAACATCTTACTTCA       TTGTGATGGTTAATAACTTACTGGAGCTAGATTGTCATGTGACAGGCTCTCCCCCACCAACTATCATG       TGGCTGAAGGATGGCCAGTTAATTGATGAAAGGGATGGATTCAAGATTTTATTAAATGGACGCAAACT                       GGTTATTGCTCAGGCTCAAGTGTCAAACACAGGCCTTTATCGGTGCATGGCAGCAAATACTGCTGGAG       ACCACAAGAAGGAATTTGAAGTGACTGTTCATGTTCCTCCAACAATCAAGTCCTCAGGCCTTTCTGAG       AGAGTTGTGGTAAAATACAAGCCTGTCGCCTTGCAGTGCATAGCCAATGGGATTCCAAATCCTTCCAT       TACATGGTTAAAAGATGACCAGCCTGTGAACACTGCCCAAGGAAACCTTAAAATACAGTCTTCTGGTC       GAGTTCTACAAATTGCCAAAACCCTGTTGGAAGATGCTGGCAGATACACATGTGTGGCTACCAACGCA       GCTGGAGAAACACAACAGCACATTCAACTGCATGTTCATGAACCACCTAGTCTGGAAGATGCTGGAAA       AATGCTGAATGAGACTGTGTTGGTGAGCAACCCTGTACAGCTGGAGTGTAAGGCAGCTGGAAATCCTG       TGCCTGTTATTACATGGTACAAAGATAATCGTCTACTCTCAGGTTCCACCAGCATGACTTTCTTGAAC       AGAGGACAGATCATTGATATTGAAAGTGCCCAGATCTCAGATGCTGGCATATATAAATGCGTGGCCAT       CAACTCAGCTGGAGCTACAGAGTTATTTTACAGTCTGCAAGTTCATGTGGCCCCATCAATTTCTGGCA       GCAATAACATGGTGGCAGTGGTGGTTAATAACCCGGTGAGGTTAGAATGTGAAGCCAGAGGTATTCCT       GCCCCAAGTCTGACCTGGTTGAAAGATGGGAGTCCTGTTTCTAGTTTTTCTAATGGATTACAGGTTCT       CTCTGGTGGTCGAATCCTAGCATTGACCAGTGCACAAATCAGCGACACAGGAAGGTACACCTGCGTGG       CAGTGAATGCTGCTGGAGAAAAGCAAAGGGACATTGACCTCCGAGTATATGTTCCGCCAAATATTATG       GGAGAAGAACAGAATGTCTCTGTCCTCATTAGCCAAGCTGTGGAATTACTATGTCAAAGTGATGCTAT       TCCCCCACCTACTCTTACTTGGTTAAAAGACGGCCACCCCTTGCTGAAGAAACCAGGCCTCAGTATAT       CTGAAAATAGAAGTGTGTTAAAGATTGAAGATGCTCAGGTTCAAGACACTGGTCGTTACACTTGTGAA       GCAACAAATGTTGCTGGAAAAACTGAAAAAAACTACAATGTCAACATTTGGGTCCCCCCAAATATTGG       TGGTTCTGATGAACTTACTCAACTTACAGTCATTGAAGGGAATCTCATTAGTCTGTTGTGTGAATCAA       GTGGTATTCCACCCCCAAATCTCATCTGGAAGAAGAAAGGCTCTCCAGTGCTGACTGATTCCATGGGG       CGAGTTAGAATTTTATCTGGGGGCAGGCAATTACAAATTTCAATTGCTGAAAAGTCTGATGCAGCACT       CTATTCATGTGTGGCGTCGAATGTTGCTGGGACTGCAAAGAAAGAATACAATCTGCAAGTTTACATTA       GACCAACCATAACCAACAGTGGCAGCCACCCTACTGAAATTATTGTGACCCGAGGGAAGAGTATCTCC       TTGGAGTGTGAGGTGCAGGGTATTCCACCACCAACAGTGACCTGGATGAAAGATGGCCACCCCTTGAT       CAAGGCAAAGGGAGTAGAAATACTGGATGAAGGTCACATCCTTCAGCTGAAGAACATTCATGTATCTG       ACACAGGCCGTTATGTGTGTGTTGCTGTGAATGTAGCAGGAATGACTGACAAAAAATATGACTTAAGT       GTCCATGGAGGCAGGATGCTACGGCTGATGCAGACCACAATGGAAGATGCTGGCCAATATACTTGCGT       TGTAAGGAATGCAGCTGGTGAAGAAAGAAAAATCTTTGGGCTTTCAGTATTAGTACCACCTCATATTG       TGGGTGAAAATACATTGGAAGATGTGAAGGTAAAAGAGAAACAGAGTGTTACGCTGACTTGTGAAGTG       ACAGGGAATCCAGTGCCAGAAATTACATGGCACAAAGATGGGCAGCCCCTCCAAGAAGATGAAGCCCA       TCACATTATATCTGGTGGCCGTTTTCTTCAAATTACCAATGTCCAGGTGCCACACACTGGAAGATATA       CATGTTTGGCTTCCAGTCCAGCTGGCCACAAGAGCAGGAGCTTCAGTCTTAATGTATTTGTATCTCCT       ACAATTGCTGGTGTAGGTAGTGATGGCAACCCTGAAGATGTCACTGTCATCCTTAACAGCCCTACATC       TTTGGTCTGTGAAGCTTATTCATATCCTCCAGCTACCATCACCTGGTTTAAGGATGGCACTCCTTTAG       AATCTAACCGAAATATTCGTATTCTTCCAGGAGGCAGAACTCTGCAGATCCTCAATGCACAGGAGGAC       AATGCTGGAAGATACTCTTGTGTAGCCACGAATGAGGCTGGAGAAATGATAAAGCACTATGAAGTGAA       GGTGTACACACTTAATGCTAACATTGTTATAATTGAATCACAGCCCCTTAAATCCGATGATCATGTTA       ATATTGCTGCGAATGGACACACACTTCAAATAAAGGAGGCTCAAATATCAGACACCGGACGATATACT       TGTGTAGCATCTAACATTGCAGGTGAAGATGAGTTGGATTTTGATGTGAATATTCAAGTTCCTCCAAG       TTTTCAGAAACTCTGGGAAATAGGAAACATGCTAGATACTGGCAGGAATGGTGAAGCCAAAGATGTGA       TCATCAACAATCCCATTTCTCTTTACTGTGAGACAAATGCTGCTCCCCCTCCTACACTGACATGGTAC               AAAGATGGCCACCCTCTGACCTCAAGTGATAAAGTATTGATTTTGCCAGGAGGGCGAGTGTTGCAGAT       TCCTCGGGCTAAAGTAGAAGATGCTGGGAGATACACATGTGTGGCTGTGAATGAGGCTGGAGAAGATT       CCCTTCAATATGATGTCCGTGTACTCGTGCCGCCAATTATCAAGGGAGCAAATAGTGATCTCCCTGAA       GAGGTCACCGTGCTGGTGAACAAGAGTGCACTGATAGAGTGTTTATCCAGTGGCAGCCCAGCACCAAG       GAATTCCTGGCAGAAAGATGGACAGCCCTTGCTAGAAGATGACCATCATAAATTTCTATCTAATGGAC       GAATTCTGCAGATTCTGAATACTCAAATAACAGATATCGGCAGGTATGTGTGTGTTGCTGAGAACACA       GCTGGGAGTGCCAAAAAATATTTTAACCTCAATGTTCATGTTCCTCCAAGTGTCATTGGTCCTAAATC       TGAAAATCTTACCGTCGTGGTGAACAATTTCATCTCTTTGACCTGTGAGGTCTCTGGTTTTCCACCTC       GGTCGAACTCTACAGATTATTCGGGCCAAGGTATCAGATGGTGGTGAATACACTTGTATAGCTATCAA       TCAAGCTGGCGAAAGCAAGAAAAAGTTTTCCCTGACTGTTTATGTGCCCCCAAGCATTAAAGACCATG       ACAGTGAATCTCTTTCTGTAGTTAATGTAAGAGAGGGAACTTCTGTGTCTTTGGAGTGTGAGTCGAAC       GCTGTGCCACCTCCAGTCATCACTTGGTATAAGAATGGGCGGATGATAACAGAGTCTACTCATGTGGA       GATTTTAGCTGATGGACAAATGCTACACATTAAGAAAGCTGAGGTATCTGACACAGGCCAGTATGTAT       GTAGAGCTATAAATGTAGCAGGACGGGATGATAAAAATTTCCACCTCAATGTATATGTGCCACCCAGT       ATTGAAGGACCTGAAAGAGAAGTGATTGTGGAGACGATCAGCAATCCTGTGACATTAACATGTGATGC       CACTGGGATCCCACCTCCCACGATAGCATGGTTAAAGAACCACAAGCGCATAGAAAATTCTGACTCAC       TGGAAGTTCGTATTTTGTCTGGAGGTAGCAAACTCCAGATTGCCCGGTCTCAGCATTCAGATAGTGGA       AACTATACATGTATTGCTTCAAATATGGAGGGAAAAGCCCAGAAATATTACTTTCTTTCAATTCAAGT       TCCTCCAAGTGTTGCTGGTGCTGAAATTCCAAGTGATGTCAGTGTCCTTCTAGGAGAAAATGTTGAGC       TGGTCTGCAATGCAAATGGCATTCCTACTCCACTTATTCAATGGCTTAAAGATGGAAAGCCCATAGCT       AGTGGTGAAACAGAAAGAATCCGAGTGAGTGCAAATGGCAGCACATTAAACATTTATGGAGCTCTTAC       ATCTGACACGGGGAAATACACATGTGTTGCTACTAATCCCGCTGGAGAAGAAGACCGAATTTTTAACT       TGAATGTCTATGTTACACCTACAATTAGGGGTAATAAAGATGAAGCAGAGAAACTAATGACTTTAGTG       GATACTTCAATAAATATTGAATGCAGAGCCACAGGGACGCCTCCACCACAGATAAACTGGCTGAAGAA       TGGACTTCCTCTGCCTCTCTCCTCCCATATCCGGTTACTGGCAGCAGGACAAGTTATCAGGATTGTGA       GAGCTCAGGTGTCTGATGTCGCTGTGTATACTTGTGTGGCCTCCAACAGAGCTGGGGTGGATAATAAG       CATTACAATCTTCAAGTGTTTGCACCACCAAATATGGACAATTCAATGGGGACAGAGGAAATCACAGT       TCTCAAAGGTAGTTCCACCTCTATGGCATGCATTACTGATGGAACCCCAGCTCCCAGTATGGCCTGGC       TTAGAGATGGCCAGCCTCTGGGGCTTGATGCCCATCTGACAGTCAGCACCCATGGAATGGTCCTGCAG       CTCCTCAAAGCAGAGACTGAAGATTCGGGAAAGTACACCTGCATTGCCTCAAATGAAGCTGGAGAAGT       CAGCAAGCACTTTATCCTCAAGGTCCTAGAACCACCTCACATTAATGGATCTGAAGAACATGAAGAGA       TATCAGTAATTGTTAATAACCCACTTGAACTTACCTGCATTGCTTCTGGAATCCCAGCCCCTAAAATG       ACCTGGATGAAAGATGGCCGGCCCCTTCCACAGACGGATCAAGTGCAAACTCTAGGAGGAGGAGAGGT       TCTTCGAATTTCTACTGCTCAGGTGGAGGATACAGGAAGATATACATGTCTGGCATCCAGTCCTGCAG       GAGATGATGATAAGGAATATCTAGTGAGAGTGCATGTACCTCCTAATATTGCTGGAACTGATGAGCCC       CGGGATATCACTGTGTTACGGAACAGACAAGTGACATTGGAATGCAAGTCAGATGCAGTGCCCCCACC       TGTAATTACTTGGCTCAGAAATGGAGAACGGTTACAGGCAACACCTCGAGTGCGAATCCTATCTGGAG       GGAGATACTTGCAAATCAACAATGCTGACCTAGGTGATACAGCCAATTATACCTGTGTTGCCAGCAAC       ATTGCAGGAAAGACTACAAGAGAATTTATTCTCACTGTAAATGTTCCTCCAAACATAAAGGGGGGCCC       CCAGAGCCTTGTAATTCTTTTAAATAAGTCAACTGTATTGGAATGCATCGCTGAAGGTGTCCCAACTC       CAAGGATAACATGGAGAAAGGATGGAGCTGTTCTAGCTGGGAATCATGCAAGATATTCCATCTTGGAA       AATGGATTCCTTCATATTCAATCAGCACATGTCACTGACACTGGACGGTATTTGTGTATGGCCACCAA       TGCTGCTGGAACAGATCGCAGGCGAATAGATTTACAGGTCCATGTTCCTCCATCTATTGCTCCGGGTC       CTACCAACATGACTGTAATAGTAAATGTTCAAACTACTCTGGCTTGTGAGGCTACTGGGATACCAAAA       CCATCAATCAATTGGAGAAAAAATGGGCATCTTCTTAATGTGGATCAAAATCAGAACTCATACAGGCT       CCTTTCTTCAGGTTCACTAGTAATTATTTCCCCTTCTGTGGATGACACTGCAACCTATGAATGTACTG       TGACAAACGGTGCTGGAGATGATAAAAGAACTGTGGATCTCACTGTCCAAGTTCCACCTTCCATAGCT               GATGAGCCTACAGATTTCCTAGTAACCAAACATGCCCCAGCAGTAATTACCTGCACTGCTTCGGGAGT       TTCTGTCCTCAGGAGCAATTGAAATACTTGCCACCCAATTAAACCATGCTGGAAGATACACTTGTGTC       GCTAGGAATGCGGCTGGCTCTGCACATCGACACGTGACCCTTCATGTTCATGAGCCTCCAGTCATTCA       GCCCCAACCAAGTGAACTACACGTCATTCTGAACAATCCTATTTTATTACCATGTGAAGCAACAGGGA       CACCCAGTCCTTTCATTACTTGGCAAAAAGAAGGCATCAATGTTAACACTTCAGGCAGAAACCATGCA       GTTCTTCCTAGTGGCGGCTTACAGATCTCCAGAGCTGTCCGAGAGGATGCTGGCACTTACATGTGTGT       GGCCCAGAACCCGGCTGGTACAGCCTTGGGCAAAATCAAGTTAAATGTCCAAGTTCCTCCAGTCATTA       GCCCTCATCTAAAGGAATATGTTATTGCTGTGGACAAGCCCATCACGTTATCCTGTGAAGCAGATGGC       CTCCCTCCGCCTGACATTACATGGCATAAAGATGGGCGTGCAATTGTGGAATCTATCCGCCAGCGCGT       CCTCAGCTCTGGCTCTCTGCAAATAACATTTGTCCAGCCTGGTGATGCTGGCCATTACACGTGCATGG       CAGCCAATGTAGCAGGATCAAGCAGCACAAGCACCAAGCTCACCGTCCATGTACCACCCAGGATCAGA       AGTACAGAAGGACACTACACGGTCAATGAGAATTCACAAGCCATTCTTCCATGCGTAGCTGATGGAAT       CCCCACACCAGCAATTAACTGGAAAAAAGACAATGTTCTTTTAGCTAACTTGTTAGGAAAATACACTG       CTGAACCATATGGAGAACTCATTTTAGAAAATGTTGTGCTGGAGGATTCTGGCTTCTATACCTGTGTT       GCTAACAATGCTGCAGGTGAAGATACACACACTGTCAGCCTGACTGTGCATGTTCTCCCCACTTTTAC       TGAACTTCCTGGAGACGTGTCATTAAATAAAGGAGAACAGCTACGATTAAGCTGTAAAGCTACTGGTA       TTCCATTGCCCAAATTAACATGGACCTTCAATAACAATATTATTCCAGCCCACTTTGACAGTGTGAAT       GGACACAGTGAACTTGTTATTGAAAGAGTGTCAAAAGAGGATTCAGGTACTTATGTGTGCACCGCAGA       GAACAGCGTTGGCTTTGTGAAGGCAATTGGATTTGTGTATGTGAAAGAACCTCCAGTCTTCAAAGGTG       ATTATCCTTCTCACTGGATTGAACCACTTGGTGGGAATGCAATCCTGAATTGTGAGGTGAAAGGAGAC       CCCACCCCAACCATCCAGTGGAACAGAAAGGGAGTGGATATTGAAATTAGCCACAGAATCCGGCAACT       GGGCAATGGCTCCCTGGCCATCTATGGCACTGTTAATGAAGATGCCGGTGACTATACATGTGTAGCTA       CCAATGAAGCTGGGGTGGTGGAGCGCAGCATGAGTCTGACTCTGCAAAGTCCTCCTATTATCACTCTT       GAGCCAGTGGAAACTGTTATTAATGCTGGTGGCAAAATCATATTGAATTGTCAGGCAACTGGAGAGCC       TCAACCAACCATTACATGGTCCCGTCAAGGGCACTCTATTTCCTGGGATGACCGGGTTAACGTGTTGT       CCAACAACTCATTATATATTGCTGATGCTCAGAAAGAAGATACCTCTGAATTTGAATGTGTTGCTCGA       AACTTAATGGGTTCTGTCCTTGTCAGAGTGCCAGTCATAGTCCAGGTTCATGGTGGATTTTCCCAGTG       GTCTGCATGGAGAGCCTGCAGTGTCACCTGTGGAAAAGGCATCCAAAAGAGGAGTCGTCTGTGCAACC       AGCCCCTTCCAGCCAATGGTGGGAAGCCCTGCCAAGGTTCAGATTTGGAAATGCGAAACTGTCAAAAT       AAGCCTTGTCCAGTGGATGGTAGCTGGTCGGAATGGAGTCTTTGGGAAGAATGCACAAGGAGCTGTGG       ACGCGGCAACCAAACCAGGACCAGGACTTGCAATAATCCATCAGTTCAGCATGGTGGGCGGCCATGTG       AAGGGAATGCTGTGGAAATAATTATGTGCAACATTAGGCCTTGCCCAGTTCATGGAGCATGGAGCGCT       TGGCAGCCTTGGGGAACATGCAGCGAAAGTTGTGGGAAAGGTACTCAGACAAGAGCAAGACTTTGTAA       AAAGAAATTGTCCAGTTCATGGCAAGTGGGCGACTTGGGCCAGTTGGAGTGCCTGTTCTGTGTCATGT       GGAGGAGGTGCCAGACAGAGAACAAGGGGCTGCTCCGACCCTGTGCCCCAGTATGGAGGAAGGAAATG       CGAAGGGAGTGATGTCCAGAGTGATTTTTGCAACAGTGACCCTTGCCCAACCCATGGTAACTGGAGTC       CTTGGAGTGGCTGGGGAACATGCAGCCGGACGTGTAACGGAGGGCAGATGCGGCGGTACCGCACATGT       GATAACCCTCCTCCCTCCAATGGGGGAAGAGCTTGTGGGGGACCAGACTCCCAGATCCAGAGGTGCAA       CACTGACATGTGTCCTGTGGATGGAAGTTGGGGAAGCTGGCATAGTTGGAGCCAGTGCTCTGCCTCCT       GTGGAGGAGGTGAAAAGACTCGGAAGCGGCTGTGCGACCATCCTGTGCCAGTTAAAGGTGGCCGTCCC       TGTCCCGGAGACACTACTCAGGTGACCAGGTGCAATGTACAAGCATGTCCAGGTGGGCCCCAGCGAGC       CAGAGGAAGTGTTATTGGAAATATTAATGATGTTGAATTTGGAATTGCTTTCCTTAATGCCACAATAA       CTGATAGCCCTAACTCTGATACTAGAATAATACGTGCCAAAATTACCAATGTACCTCGTAGTCTTGGT       TCAGCAATGAGAAAGATAGTTTCTATTCTAAATCCCATTTATTGGACAACAGCAAAGGAAATAGGAGA       AGCAGTCAATGGCTTTACCCTCACCAATGCAGTCTTCAAAAGAGAAACTCAAGTGGAATTTGCAACTG       GAGAAATCTTGCAGATGAGTCATATTGCCCGGGGCTTGGATTCCGATGGTTCTTTGCTGCTAGATATC       GTTGTGAGTGGCTATGTCCTACAGCTTCAGTCACCTGCTGAAGTCACTGTAAAGGATTACACAGAGGA               CTACATTCAAACAGGTCCTGGGCAGCTGTACGCCTACTCAACCCGGCTGTTCACCATTGATGGCATCA       GCATCCCATACACATGGAACCACACCGTTTTCTATGATCAGGCACAGGGAAGAATGCCTTTCTTGGTT       GAAACACTTCATGCATCCTCTGTGGAATCTGACTATAACCAGATAGAAGAGACACTGGGTTTTAAAAT       TCATGCTTCAATATCCAAAGGAGATCGCAGTAATCAGTGCCCCTCCGGGTTTACCTTAGACTCAGTTG       GACCTTTTTGTGCTGATGAGGATGAATGTGCAGCAGGGAATCCCTGCTCCCATAGCTGCCACAATGCC       ATGGGGACTTACTACTGCTCCTGCCCTAAAGGCCTCACCATAGCTGCAGATGGAAGAACTTGTCAAGA       TATTGATGAGTGTGCTTTGGGTAGGCATACCTGCCACGCTGGTCAGGACTGTGACAATACGATTGGAT       CTTATCGCTGTGTGGTCCGTTGTGGAAGTGGCTTTCGAAGAACCTCTGATGGGCTGAGTTGTCAAGAT       ATTAATGAATGTCAAGAATCCAGCCCCTGTCACCAGCGCTGTTTCAATGCCATAGGAAGTTTCCATTG       TGGATGTGAACCTGGGTATCAGCTCAAAGGCAGAAAATGCATGGATGTGAACGAGTGTAGACAAAATG       TATGCAGACCAGATCAGCACTGTAAGAACACCCGTGGTGGCTATAAGTGCATTGATCTTTGTCCAAAT       GGAATGACCAAGGCAGAAAATGGAACCTGTATTGATATTGATGAATGTAAAGATGGGACCCATCAGTG       CAGATATAACCAGATATGTGAGAATACAAGAGGCAGCTATCGTTGTGTATGCCCAAGAGGTTATCGGT       CTCAAGGAGTTGGAAGACCCTGCATGGACATTAATGAATGTGAACAAGTGCCTAAACCTTGTGCACAT       CAGTGCTCCAACACCCCCGGCAGCTTCAAGTGTATCTGTCCACCAGGACAACATTTATTAGGGGACGG       GAAATCTTGCGCTGGATTGGAGAGGCTGCCAAATTATGGCACTCAATACAGTAGCTATAACCTTGCAC       GGTTCTCCCCTGTGAGAAACAACTATCAACCTCAACAGCATTACAGACAGTACTCACATCTCTACAGC       TCCTACTCAGAGTATAGAAACAGCAGAACATCTCTCTCCAGGACTAGAAGGACTATTAGGAAAACTTG       CCCTGAAGGCTCTGAGGCAAGCCATGACACATGTGTAGATATTGATGAATGTGAAAATACAGATGCCT       GCCAGCATGAGTGTAAGAATACCTTTGGAAGTTATCAGTGCATCTGCCCACCTGGCTATCAACTCACA       CACAATGGAAAGACATGCCAAGATATCGATGAATGTCTGGAGCAGAATGTGCACTGTGGACCCAATCG       CATGTGCTTCAACATGAGAGGAAGCTACCAGTGCATCGATACACCCTGTCCACCCAACTACCAACGGG       ATCCTGTTTCAGGGTTCTGCCTCAAGAACTGTCCACCCAATGATTTGGAATGTGCCTTGAGCCCATAT       GCCTTGGAATACAAACTCGTCTCCCTCCCATTTGGAATAGCCACCAATCAAGATTTAATCCGGCTGGT       TGCATACACACAGGATGGAGTGATGCATCCCAGGACAACTTTCCTCATGGTAGATGAGGAACAGACTG       TTCCTTTTGCCTTGAGGGATGAAAACCTGAAAGGAGTGGTGTATACAACACGACCACTACGAGAAGCA       GAGACCTACCGCATGAGGGTCCGAGCCTCATCCTACAGTGCCAATGGGACCATTGAATATCAGACCAC       ATTCATAGTTTATATAGCTGTGTCCGCCTATCCATAC TAA   GGAACTCTCCAAAGCCTATTCCACATAT           TTAAACCGCATTAATCATGGCAATCAAGCCCCCTTCCAGATTACTGTCTCTTGAACAGTTGCAATCTT           GGCAGCTTGAAAATGGTGCTACACTCTGTTTTGTGTGCCTTCCTTGGTACTTCTGAGGTATTTTCATG           ATCCCACCATGGTCATATCTTGAAGTATGGTCTAGAAAAGTCCCTTATTATTTTATTTATTACACTGC           AGCACTTACTTCCCAAAGATTATTCTGAACATCTAACAGGACATATCAGTGATGGTTTACAGTAGTGT           AGTACCTAAGATCATTTTCCTGAAAGCCAAACCAAACAACGAAAAACAAGAACAACTAATTCAGAATC           AAATAGAGTTTTTGAGCATTTGACTATTTTTAGAATCATAAAATTAGTTACTAAGTATTTTGATCAAA           GCTTATAAAATAACTTACGGAGATTTTTGTAAGTATTGATACATTATAATAGGACTTGCCTATTTTCA           TTTTTAAGAAGAAAAACCCG                                                   NOV43c, CG56914-02   SEQ ID NO:1002   4495 aa   MW at 488830.5 kD               Protein Sequence                     MWLDRCARNPPRNHIDAPQKAPSAFRRVLQKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTAT           NTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPTITWAKETQLISP       FSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDI       PCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHV       QEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIA       SVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMW       YKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLGTNFPNEVSVVLN       RDVALECQVKGTPFPDIHWFKDGNIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSS       SQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLMKQVVIAHSL       TLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEV       DVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQA       QVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKD       DQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNET       VLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGA       TELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI       LALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTL       TWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDEL       TQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRTLSGGRQLQISIAEKSDAALYSCVA       SNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGV       EILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHGGRMLRLMQTTMEDAGQYTCVVRNAA       GEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISG       GRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEA       YSYPPATITWFKDGTPLESNPNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYTLN       ANIVIIESQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLW       EIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKV       EDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQK       DGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTV       VVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGES       KKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILANG       QMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPP       PTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVA       GAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGK       YTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLP       LSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSS       TSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFI       LKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRIST       AQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWL       RNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVI       LLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTD       RRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGS       LVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSI       HWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSE       LHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPA       GTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGS       LQITFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAI       NWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGD       VSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGF       VKAIGFVYVKEPPVFKGDYPSHWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSL       AIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTIT               WSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRA       CSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMENCQNKPCPVDGSWSEWSLWEECTRSCGRGNQT       RTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHGAWSAWQPWGTCSESCGKGTQTRAELCNNPPPA       FGGSYCDGAETQMQVCNERNCPVHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDV       QSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCP       VDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVI       GNINDVEFGIAFLNATITDSPNSDTRIIRAKITNVPRSLGSAMRKIVSILNPIYWTTAKEIGEAVNGF       TLTNAVFKRETQVEFATGEILQMSHIARGLDSDGSLLLDIVVSGYVLQLQSPAEVTVKDYTEDYIQTG       PGQLYAYSTRLFTIDGISIPYTWNHTVFYDQAQGRMPFLVETLHASSVESDYNQIEETLGFKIHASIS       KGDRSNQCPSGFTLDSVGPFCADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECA       LGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQRCFNAIGSFHCGCEPG       YQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQCRYNQI       CENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAG       LERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSE       ASHDTCVDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNM       RGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLPFGIATNQDLIRLVAYTQD       GVMHPRTTFLMVDEEQTVPFALRDENLKGVVYTTRPLREAETYRMRVRASSYSANGTIEYQTTFIVYI       AVSAYPY                                     NOV43d, CG56914-03   SEQ ID NO:1003   6343 bp           DNA Sequence   ORF Start: ATG at 105   ORF Stop: TAA at 5811                       AACCACCTCACATTAATGGATCTGAAGAACATGAAGAGATATCAGTAATTGTTAATAACCCACTTGAA               CTTACCTGCATTGCTTCTGGAATCCCAGCCCCTAAA   ATG ACCTGGATGAAAGATGGCCGGCCCCTTCC       ACAGACGGATCAAGTGCAAACTCTAGGAGGAGGAGAGGTTCTTCGAATTTCTACTGCTCAGGTGGAGG       ATACAGGAAGATATACATGTCTGGCATCCAGTCCTGCAGGAGATGATGATAAGGAATATCTAGTGAGA       GTGCATGTACCTCCTAATATTGCTGGAACTGATGAGCCCCGGGATATCACTGTGTTACGGAACAGACA       AGTGACATTGGAATGCAAGTCAGATGCAGTGCCCCCACCTGTAATTACTTGGCTCAGAAATGGAGAAC       GGTTACAGGCAACACCTCGAGTGCGAATCCTATCTGGAGGGAGATACTTGCAAATCAACAATGCTGAC       CTAGGTGATACAGCCAATTATACCTGTGTTGCCAGCAACATTGCAGGAAAGACTACAAGAGAATTTAT       TCTCACTGTAAATGTTCCTCCAAACATAAAGGGGGGCCCCCAGAGCCTTGTAATTCTTTTAAATAAGT       CAACTGTATTGGAATGCATCGCTGAAGGTGTGCCAACTCCAAGGATAACATGGAGAAAGGATGGAGCT       GTTCTAGCTGGGAATCATGCAAGATATTCCATCTTGGAAAATGGATTCCTTCATATTCAATCAGCACA       TGTCACTGACACTGGACGGTATTTGTGTATGGCCACCAATGCTGCTGGAACAGATCGCAGGCGAATAG       ATTTACAGGTCCATGGTTCACTAGTAATTATTTCCCCTTCTGTGGATGACACTGCAACCTATGAATGT       ACTGTGACAAACGGTGCTGGAGATGATAAAAGAACTGTGGATCTCACTGTCCAAGTTCCACCTTCCAT       AGCTGATGAGCCTACAGATTTCCTAGTAACCAAACATGCCCCAGCAGTAATTACCTGCACTGCTTCGG       GAGTTCCATTTCCCTCAATTCACTGGACCAAAAATGGTATAAGACTGCTTCCCAGGGGAGATGGCTAT       AGAATTCTGTCCTCAGGAGCAATTGAAATACTTGCCACCCAATTAAACCATGCTGGAAGATACACTTG       TGTCGCTAGGAATGCGGCTGGCTCTGCACATCGACACGTGACCCTTCATGTTCATGAGCCTCCAGTCA       TTCAGCCCCAACCAAGTGAACTACACGTCATTCTGAACAATCCTATTTTATTACCATGTGAAGCAACA       GGGACACCCAGTCCTTTCATTACTTGGCAAAAAGAAGGCATCAATGTTAACACTTCAGGCAGAAACCA       TGCAGTTCTTCCTAGTGGCGGCTTACAGATCTCCAGAGCTGTCCGAGAGGATGCTGGCACTTACATGT       GTGTGGCCCAGAACCCGGCTGGTACAGCCTTGGGCAAAATCAAGTTAAATGTCCAAGTTCCTCCAGTC       ATTAGCCCTCATCTAAAGGAATATGTTATTGCTGTGGACAAGCCCATCACGTTATCCTGTGAAGCAGA       TGGCCTCCCTCCGCCTGACATTACATGGCATAAAGATGGGCGTGCAATTGTGGAATCTATCCGCCAGC       GCGTCCTCAGCTCTGGCTCTCTGCAAATAGCATTTGTCCAGCCTGGTGATGCTGGCCATTACACGTGC       ATGGCAGCCAATGTAGCAGGATCAAGCAGCACAAGCACCAAGCTCACCGTCCATGTACCACCCAGGAT       CAGAAGTACAGAAGGACACTACACGGTCAATGAGAATTCACAAGCCATTCTTCCATGCGTAGCTGATG       GAATCCCCACACCAGCAATTAACTGGAAAAAAGACAATGTTCTTTTAGCTAACTTGTTAGGAAAATAC       ACTGCTGAACCATATGGAGAACTCATTTTAGAAAATGTTGTGCTGGAGGATTCTGGCTTCTATACCTG       TGTTGCTAACAATGCTGCAGGTGAAGATACACACACTGTCAGCCTGACTGTGCATGTTCTCCCCACTT       TTACTGAACTTCCTGGAGACGTGTCATTAAATAAAGGAGAACAGCTACGATTAAGCTGTAAAGCTACT       GGTATTCCATTGCCCAAATTAACATGGACCTTCAATAACAATATTATTCCAGCCCACTTTGACAGTGT       GAATGGACACAGTGAACTTGTTATTGAAAGAGTGTCAAAAGAGGATTCAGGTACTTATGTGTGCACCG       CAGAGAACAGCGTTGGCTTTGTGAAGGCAATTGGATTTGTTTATGTGAAAGAACCTCCAGTCTTCAAA       GGTGATTATCCTTCTAACTGGATTGAACCACTTGGTGGGAATGCAATCCTGAATTGTGAGGTGAAAGG       AGACCCCACCCCAACCATCCAGTGGAACAGAAAGGGAGTGGATATTGAAATTAGCCACAGAATCCGGC       AACTGGGCAATGGCTCCCTGGCCATCTATGGCACTGTTAATGAAGATGCCGGTGACTATACATGTGTA       GCTACCAATGAAGCTGGGGTGGTGGAGCGCAGCATGAGTCTGACTCTGCAAAGTCCTCCTATTATCAC       TCTTGAGCCAGTGGAAACTGTTATTAATGCTGGTGGCAAAATCATATTGAATTGTCAGGCAACTGGAG       AGCCTCAACCAACCATTACATGGTCCCGTCAAGGGCACTCTATTTCCTGGGATGACCGGGTTAACGTG       TTGTCCAACAACTCATTATATATTGCTGATGCTCAGAAAGAAGATACCTCTGAATTTGAATGCGTTGC       TCGAAACTTAATGGGTTCTGTCCTTGTCAGAGTGCCAGTCATAGTCCAGGTTCATGGTGGATTTTCCC       AGTGGTCTGCATGGAGAGCCTGCAGTGTCACCTGTGGAAAAGGCATCCAAAAGAGGAGTCGTCTGTGC       AACCAGCCCCTTCCAGCCAATGGTGGGAAGCCCTGCCAAGGTTCAGATTTGGAAATGCGAAACTGTCA       AAATAAGCCTTGTCCAGTGGATGGTAGCTGGTCGGAATGGAGTCTTTGGGAAGAATGCACAAGGAGCT       GTGGACGCGGCAACCAAACCAGGACCAGGACTTGCAATAATCCATCAGTTCAGCATGGTGGGCGGCCA       TGTGAAGGGAATGCTGTGGAAATAATTATGTGCAACATTAGGCCTTGCCCAGTTCATGGAGCATGGAG       CGCTTGGCAGCCTTGGGGAACATGCAGCGAAAGTTGTGGGAAAGGTACTCAGACAAGAGCAAGACTTT       GTAATAACCCACCACCAGCGTTTGGTGGGTCCTACTGTGATGGAGCAGAAACACAGATGCAAGTTTGC               AATGAAAGAAATTGTCCAATTCATGGCAAGTGGGCGACTTGGGCCAGTTGGAGTGCCTGTTCTGTGTC       ATGTGGAGGAGGTGCCAGACAGAGAACAAGGGGCTGCTCCGACCCTGTGCCCCAGTATGGAGGAAGGA       AATGCGAAGGGAGTGATGTCCAGAGTGATTTTTGCAACAGTGACCCTTGCCCAACCCATGGTAACTGG       AGTCCTTGGAGTGGCTGGGGAACATGCAGCCGGACGTGTAACGGAGGGCAGATGCGGCGGTACCGCAC       ATGTGATAACCCTCCTCCCTCCAATGGGGGAAGAGCTTGTGGGGGACCAGACTCCCAGATCCAGAGGT       GCAACACTGACATGTGTCCTGTGGATGGAAGTTGGGGAAGCTGGCATAGTTGGAGCCAGTGCTCTGCC       TCCTGTGGAGGAGGTGAAAAGACTCGGAAGCGGCTGTGCGACCATCCTGTGCCAGTTAAAGGTGGCCG       TCCTTGTCCCGGAGACACTACTCAGGTGACCAGGTGCAATGTACAAGCATGTCCAGGTGGGCCCCAGC       GAGCCAGAGGAAGTGTTATTGGAAATATTAATGATGTTGAATTTGGAATTGCTTTCCTTAATGCCACA       ATAACTGATAGCCCTAACTCTGATACTAGAATAATACGTGCCAAAATTACCAATGTACCTCGTAGTCT       TGGTTCAGCAATGAGAAAGATAGTTTCTATTCTAAATCCCATTTATTGGACAACAGCAAAGGAAATAG       GAGAAGCAGTCAATGGCTTTACCCTCACCAATGCAGTCTTCAAAAGAGAAACTCAAGTGGAATTTGCA       ACTGGAGAAATCTTGCAGATGAGTCATATTGCCCGGGGCTTGGATTCCGATGGTTCTTTGCTGCTAGA       TATCGTTGTGAGTGGCTATGTCCTACAGCTTCAGTCACCTGCTGAAGTCACTGTAAAGGATTACACAG       AGGACTACATTCAAACAGGTCCTGGGCAGCTGTACGCCTACTCAACCCGGCTGTTCACCATTGATGGC       ATCAGCATCCCATACACATGGAACCACACCGTTTTCTATGATCAGGCACAGGGAAGAATGCCTTTCTT       GGTTGAAACACTTCATGCATCCTCTGTGGAATCTGACTATAACCAGATAGAAGAGACACTGGGTTTTA       AAATTCATGCTTCAATATCCAAAGGAGATCGCAGTAATCAGTGCCCCTCCGGGTTTACCTTAGACTCA       GTTGGACCTTTTTGTGCTGATGAGGATGAATGTGCAGCAGGGAATCCCTGCTCCCATAGCTGCCACAA       TGCCATGGGGACTTACTACTGCTCCTGCCCTAAAGGCCTCACCATAGCTGCAGATGGAAGAACTTGTC       AAGATATTGATGAGTGTGCTTTGGGTAGGCATACCTGCCACGCTGGTCAGGACTGTGACAATACGATT       GGATCTTATCGCTGTGTGGTCCGTTGTGGAAGTGGCTTTCGAAGAACCTCTGATGGGCTGAGTTGTCA       AGATATTAATGAATGTCAAGAATCCAGCCCCTGTCACCAGCGCTGTTTCAATGCCATAGGAAGTTTCC       ATTGTGGATGTGAACCTGGGTATCAGCTCAAAGGCAGAAAATGCATGGATGTGAACGAGTGTAGACAA       AATGTATGCAGACCAGATCAGCACTGTAAGAACACCCGTGGTGGCTATAAGTGCATTGATCTTTGTCC       AAATGGAATGACCAAGGCAGAAAATGGAACCTGTATTGATATTGATGAATGTAAAGATGGGACCCATC       AGTGCAGATATAACCAGATATGTGAGAATACAAGAGGCAGCTATCGTTGTGTATGCCCAAGAGGTTAT       CGGTCTCAAGGAGTTGGAAGACCCTGCATGGATATTGATGAATGTGAAAATACAGATGCCTGCCTGCA       TGAGTGTAAGAATACCTTTGGAAGTTATCAGTGCATCTGCCCACCTGGCTATCAACTCACACACAATG       GAAAGACATGCCAAGATATCGATGAATGTCTGGAGCAGAATGTGCACTGTGGACCCAATCGCATGTGC       TTCAACATGAGAGGAAGCTACCAGTGCATCGATACACCCTGTCCACCCAACTACCAACGGGATCCTGC       TTCAGGGTTCTGCCTCAAGAACTGTCCACCCAATGATTTGGAATGTGCCTTGAGCCCATATGCCTTGG       AATACAAACTCGTCTCCCTCCCATTTGGAATAGCCACCAATCAAGATTTAATCCGGCTGGTTGCATAC       ACACAGGATGGAGTGATGCATCCCAGGACAACTTTCCTCATGGTAGATGAGGAACAGACTGTTCCTTT       TGCCTTGAGGGATGAAAACCTGAAAGGAGTGGTGTATACAACACGACCACTACGAGAAGCAGAGACCT       ACCGCATGAGGGTCCGAGCCTCATCCTACAGTGCCAATGGGACCATTGAATATCAGACCACATTCATA       GTTTATATAGCTGTGTCCGCCTATCCATAC TAA   GGAACTCTCCAAAGCCTATTCCACATATTTAAACC           GCATTAATCATGGCAATCAAGCCCCCTTCCAGATTACTGTCTCTTGAACAGTTGCAATCTTGGCAGCT           TGAAAATGGTGCTACACTCTGTTTTGTGTGCCTTCCTTGGTACTTCTGAGGTATTTTCATGATCCCAC           CATGGTCATATCTTGAAGTATGGTCTAGAAAAGTCCCTTATTATTTTATTTATTACACTGGAGCAGTT           ACTTCCCAAAGATTATTCTGAACATCTAACAGGACATATCAGTGATGGTTTACAGTAGTGTAGTACCT           AAGATCATTTTCCTGAAAGCCAAACCAAACAACGAAAAACAAGAACAACTAATTCAGAATCAAATAGA           GTTTTTGAGCATTTGACTATTTTTAGAATCATAAAATTAGTTACTAAGTATTTTGATCAAAGCTTATA           AAATAACTTACGGAGATTTTTGTAAGTATTGATACATTATAATAGGACTTGCCTATTTTCATTTTTAA           GAAGAAAAACACCACTCAT                                                   NOV43d, CG56914-03   SEQ ID NO:1004   1902 aa   MW at 207163.2 kD               Protein Sequence                     MTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDE           PRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVAS       NIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSIL       ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHGSLVIISPSVDDTATYECTVTNGAGDDKRT       VDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIElLA       TQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKE       GINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAV       DKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTS       TKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILEN       VVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFN       NNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLG       GNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSM       SLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQ       KEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPC       QGSDLEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCN       IRPCPVHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWA       TWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSDPCPTHGNWSPWSGWGTCSRT       CNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRL       CDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDSPNSDTRII       RAKITNVPRSLGSAMRKIVSILNPIYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGEILQMSHIAR       GLDSDGSLLLDIVVSGYVLQLQSPAEVTVKDYTEDYIQTGPGQLYAYSTRLFTIDGISIPYTWNHTVF       YDQAQGRMPFLVETLHASSVESDYNQIEETLGFKIHASISKGDRSNQCPSGFTLDSVGPFCADEDECA       AGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSG       FRRTSDGLSCQDINECQESSPCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNT       RGGYKCIDLCPNGMTKAENGTCIDIDECKDGTBQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDI       DECENTDACLHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRNCFNMRGSYQCIDT       PCPPNYQRDPASGFCLKNCPPNDLECALSPYALEYKLVSLPFGIATNQDLIRLVAYTQDGVMHPRTTF       LMVDEEQTVPFALRDENLKGVVYTTRPLREAETYRMRVRASSYSANGTIEYQTTFIVYIAVSAYPY                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 43B.  
               TABLE 43B                       Comparison of the NOV43 protein sequences.                                                NOV43a   ------------------------------------------------------------   (SEQ ID NO:998)                   NOV43b   ------------------------------------------------------------   (SEQ ID NO:1000)               NOV43c   MWLDRCARNPPRNHIDAPQKAPSAFRRVLQKGELISTSSAKFSAGADGSLYVVSPGGEES   (SEQ ID NO:1002)               NOV43d   ------------------------------------------------------------   (SEQ ID NO:1004)               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   GEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSL               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   PPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLN               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   VHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTL               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   SIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEF               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   PCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGT               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   TERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESST               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43c   IQTVNNGKILKLFEATPEDAGRYSCKAINIAGTSQKYFNIDVLGTNFPNEVSVVLNRDVA               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43c   LECQVKGTPFPDIHWFKDGNIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQP               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   IMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLAT               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   PLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNTRIEAGGKKLEIMSAQEIDR               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   GQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIM               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   WLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPT               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   IKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAK               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   TLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGN               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   PVPVITWYKDNRNLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQ               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   VHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   LALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQS               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   DAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNY               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   NVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRI               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   LSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRG               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   KSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVN               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   VAGMTDKKYDLSVHGGRMLRLMQTTMEDAGQYTCVVPNAAGEERKIFGLSVLVPPHIVGE               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   NTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVP               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   HTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYP               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   PATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKV               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   YTLNANIVIIESQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDV               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   NIQVPPSFQKLWEIGNNLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTS               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   SDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPE               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   EVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGR               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   YVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLK               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   NEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKD               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   HDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKA               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   EVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPP               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   PTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLS               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   IQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSAN               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   GSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTST               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   NIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAG               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   VDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRNGQPLGLDA               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   HLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISV               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   IVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCL               NOV43d   -------------------MTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCL               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   ASSPAGDDDKEYLVRVHVPPNTAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGE               NOV43d   ASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGE               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   RLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQ               NOV43d   RLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQ               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   SLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSTLENGFLHIQSAHVTDTGR               NOV43d   SLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGR               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   YLCMATNAAGTDRIRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKN               NOV43d   YLCMATNAAGTDRRRIDLQVHG--------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   GHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIA               NOV43d   -------------------SLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIA               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   DEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLN               NOV43d   DEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLN               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   HAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFIT               NOV43d   HAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFIT               NOV43a   ------------------------------------MCVAQNPAGTALGKIKLNVQVPPV               NOV43b   ---------------------------------GSTMCVAQNPAGTALGKIKLNVQVPPV               NOV43c   WQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPV               NOV43d   WQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPV               NOV43a   ISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQP               NOV43b   ISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQP               NOV43c   ISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQITFVQP               NOV43d   ISPHLKEYVTAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQP               NOV43a   GDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAI               NOV43b   GDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAI               NOV43c   GDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAI               NOV43d   GDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAI               NOV43a   NWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLP               NOV43b   NWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLP               NOV43c   NWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLP               NOV43d   NWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLP               NOV43a   TFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSK               NOV43b   TFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSK               NOV43c   TFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSK               NOV43d   TFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSK               NOV43a   EDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPT               NOV43b   EDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPT               NOV43c   EDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSHWIEPLGGNAILNCEVKGDPTPT               NOV43d   EDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPT               NOV43a   IQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPP               NOV43b   IQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLRSPP               NOV43c   IQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPP               NOV43d   IQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPP               NOV43a   IITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQ               NOV43b   IITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQ               NOV43c   IITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQ               NOV43d   IITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQ               NOV43a   KEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPL               NOV43b   KEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPL               NOV43c   KEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPL               NOV43d   KEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWPACSVTCGKGIQKRSRLCNQPL               NOV43a   PANGGKPCQGSDLEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQH               NOV43b   PANGGKPCQGSDLEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQH               NOV43c   PANGGKPCQGSDLEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQH               NOV43d   PANGGKPCQGSDLEMPNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQH               NOV43a   GGRPCEGNAVEIIMCNIRPCPVHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGS               NOV43b   GGRPCEGNAVEIIMCNIRPCPVHGAWSAWQLWGTCSESCGKGTQTRARLCNNPPPAFGGS               NOV43c   GGRPCEGNAVEIIMCNIRPCPVHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGS               NOV43d   GGRPCEGNAVEIIMCNIRPCPVHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGS               NOV43a   YCDGAETQMQVCNERICPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCE               NOV43b   YCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCE               NOV43c   YCDGAETQMQVCNERNCPVHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCE               NOV43d   YCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCE               NOV43a   GSDVQSDFCNSDPCPSECWKYPW-------------------------------------               NOV43b   GSDVQSDFCNSDPCPSECWKYPWLE-----------------------------------               NOV43c   GSDVQSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPD               NOV43d   GSDVQSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPD               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   SQIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQV               NOV43d   SQIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQV               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   TRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDSPNSDTRIIRAKITNVPRSLG               NOV43d   TRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDSPNSDTRIIRAKITNVPRSLG               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   SAMRKIVSILNPIYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGEILQMSHIARGLDS               NOV43d   SAMRKIVSILNPIYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGEILQMSHIARGLDS               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   DGSLLLDIVVSGYVLQLQSPAEVTVKDYTEDYIQTGPGQLYAYSTRLFTIDGISIPYTWN               NOV43d   DGSLLLDIVVSGYVLQLQSPAEVTVKDYTEDYIQTGPGQLYAYSTRLFTIDGISIPYTWN               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   HTVFYDQAQGRNPFLVETLHASSVESDYNQIEETLGFKTHASISKGDRSNQCPSGFTLDS               NOV43d   HTVFYDQAQGRMPFLVETLHASSVESDYNQIEETLGFKIHASISKGDRSNQCPSGFTLDS               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   VGPFCADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRRTCHA               NOV43d   VGPFCADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHA               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   GQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQRCFNAIGSFHCGCEPG               NOV43d   GQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQRCFNAIGSFHCGCEPG               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   YQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGT               NOV43d   YQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGT               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   HQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCI               NOV43d   HQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDI------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   CPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSE               NOV43d   ------------------------------------------------------------               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   YRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDECENTDACQHECKNTFGSYQCICPPG               NOV43d   ---------------------------------DECENTDACLHECKNTFGSYQCICPPG               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   YQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNC               NOV43d   YQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPASGFCLKNC               NOV43a   ------------------------------------------------------------               NOV43b   ------------------------------------------------------------               NOV43c   PPNDLECALSPYALEYKLVSLPFGIATNQDLIRLVAYTQDGVMHPRTTFLMVDEEQTVPF               NOV43d   PPNDLECALSPYALEYKLVSLPFGIATNQDLIRLVAYTQDGVMHPRTTFLMVDEEQTVPF               NOV43a   -------------------------------------------------------               NOV43b   -------------------------------------------------------               NOV43c   ALRDENLKGVVYTTRPLREAETYRMRVRASSYSANGTIEYQTTFIVYIAVSAYPY               NOV43d   ALRDENLKGVVYTTRPLREAETYRNRVRASSYSANGTIEYQTTFIVYIAVSAYPY                  
 
      Further analysis of the NOV43a protein yielded the following properties shown in Table 43C.  
               TABLE 43C                       Protein Sequence Properties NOV43a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 0; pos. chg 0; neg. chg 0           H-region:   length 13; peak value 2.20           PSG score:   −2.20                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −8.62           possible cleavage site: between 48 and 49                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 0           number of TMS(s) . . . fixed                             PERIPHERAL   Likelihood = 0.63 (at 454)                         ALOM score: 0.63 (number of TMSs: 0)       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   4.71           Hyd Moment(95):   3.65   G content:   2           D/E content:   1   S/T content:   2                         Score: −5.83       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 8.5%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         KKXX-like motif in the C-terminus: WKYP                 SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear           discrimination           Prediction: nuclear           Reliability: 55.5       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         73.9%: nuclear           13.0%: mitochondrial           13.0%: cytoplasmic                 &gt;&gt; prediction for CG56914-01 is nuc (k = 23)                  
 
      A search of the NOV43a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 43D.  
               TABLE 43D                          Geneseq Results for NOV43a                                         NOV43a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value                                             ABU12084   Human NOV25c CG56914-03 protein   1 . . . 707   701/707   (99%)   0.0           SEQ ID 88 -  Homo sapiens , 1902 aa.   441 . . . 1147    702/707   (99%)           [WO200281625-A2, 17-OCT-2002]       ABP60991   Novel human protein. SEQ ID 78 -   1 . . . 707   701/707   (99%)   0.0             Homo sapiens , 5635 aa.   4057 . . . 4763    702/707   (99%)           [WO200250105-A1, 27-JUN-2002]       AAB47771   Human thrombospondin protein,   1 . . . 707   699/707   (98%)   0.0           BTL.012 -  Homo sapiens , 1336 aa.   184 . . . 890    702/707   (98%)           [WO200174852-A2, 11-OCT-2001]       ABU12083   Human NOV25b CG93858-02 protein   1 . . . 707   698/707   (98%)   0.0           SEQ ID 86 -  Homo sapiens , 2572 aa.   1111 . . . 1817    701/707   (98%)           [WO200281625-A2, 17-OCT-2002]       ABG03933   Novel human diagnostic protein #3924 -   1 . . . 471   471/471   (100%)   0.0             Homo sapiens , 1240 aa.   442 . . . 912    471/471   (100%)           [WO200175067-A2, 11-OCT-2001]                  
 
      In a BLAST search of public sequence databases, the NOV43a protein was found to have homology to the proteins shown in the BLASTP data in Table 43E.  
               TABLE 43E                          Public BLASTP Results for NOV43a                                         NOV43a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q96RW7   Hemicentin -  Homo sapiens     1 . . . 707   700/707 (99%)   0.0           (Human), 5636 aa.   4058 . . . 4764    701/707 (99%)       Q96SC3   Fibulin-6 -  Homo sapiens  (Human),   1 . . . 707   698/707 (98%)   0.0           2673 aa (fragment).   1095 . . . 1801    701/707 (98%)       Q8NDA2   Hypothetical protein -  Homo sapiens     2 . . . 489   208/503 (41%)    e−111           (Human), 1340 aa (fragment).   824 . . . 1326    285/503 (56%)       Q96DN3   Hypothetical protein FLJ31995 -   1 . . . 460   159/475 (33%)   1e−63             Homo sapiens  (Human), 1252 aa   782 . . . 1252    235/475 (49%)           (fragment).       Q8I0L3     C. elegans  him-4 protein   2 . . . 511   159/529 (30%)   1e−59           (corresponding sequence F15G9.4a) -   3014 . . . 3521    241/529 (45%)             Caenorhabditis elegans , 5175 aa.                  
 
      PFam analysis predicts that the NOV43a protein contains the domains shown in the Table 43F.  
               TABLE 43F                          Domain Analysis of NOV43a                                             Identities/               Pfam   NOV43a   Similarities for   Expect           Domain   Match Region   the Matched Region   Value                       ig   37 . . . 94   21/61 (34%)   1.1e−09                   44/61 (72%)           ig   127 . . . 185   17/62 (27%)   3.2e−06                   38/62 (61%)           ig   218 . . . 274   20/60 (33%)   1.3e−10                   44/60 (73%)           ig   308 . . . 365   21/61 (34%)   5.3e−09                   43/61 (70%)           ig   398 . . . 455   18/61 (30%)   3.5e−08                   42/61 (69%)           tsp_1   477 . . . 527   28/53 (53%)   8.9e−17                   37/53 (70%)           tsp_1   534 . . . 584   25/53 (47%)   4.8e−14                   42/53 (79%)           tsp_1   591 . . . 641   22/53 (42%)   2.7e−12                   36/53 (68%)           tsp_1   648 . . . 698   23/53 (43%)   1.7e−14                   37/53 (70%)                      
 
     Example 44  
      The NOV44 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 44A.  
               TABLE 44A                       NOV44 Sequence Analysis                                                NOV44a, CG56959-02   SEQ ID NO: 1005   1599 bp           DNA Sequence   ORF Start: ATG at 25   ORF Stop: TAA at 1594                       GACTCACGAAAGAAAAGCCAAACG   ATG AGTTTCCACAAGGAGGACGGAGTGAACAGTCTGTGCCAGAA           GGCTCTGCACATCGTCACCGAGCTGTGCTTCGCCGGCCAGGTGGAGTGGGAGAAGTGCTCGGGCATCT       TCCCTCGGGACAGGGGCAGCCAGGGCGGAAGCAGCACAGATATTTCAGTCAGCCTGTTAGCAGTCGTT       GTCAGCTTTTGTGGACTGGCCTTGTTGGTTGTCTCACTTTTTGTCTTCTGGAAGCTGTGTTGGCCATG       CTGGAAAAGCAAACCTGTGACTTCCAACATCACTACCCTTCCACAGAGCATTTCAAGTGCTCCTACTG       AAGTTTTTGAGACTGAAGAGAAAAAAGAAATTAAGGAAAATGAAAAGCCAGCCGTAAAAGCTATTGAG       CCTGCAATAAAAATCAGCCACACTTCCCCTGACATCCCAGCAGAAGTCCAAACTGCTTTAAAAGAACA       TTTAATTAAACATGCACGTGTGCAAAGACAAATTACTGAGCCTACGTCATCAACCCGCCACAGTTCCT       TCCGAAGACACCTGCCGAGGCAAATGCAGGTTTCCAGTGTTGATTTTAGCATGGGCACAGAACCTGTT       TTACAACGAGGAGAAACAACAACCAGCATTGGGAGGATAAAGCCAGAACTCTACAAACAGAAATCAGT       TGACTCTGAGGGCAACCAAAACGAAGATGTCAAAATCTGTGGGAAACTTAACTTTACCCTCCAGTATG       ATTATGAAAATGAACTTCTAGTTGTTAAAATTATCAAAGCTTTAGATCTCCCTGCTAAAGACTTCACA       GGAACTTCTGACCCTTATGTGAAGATGTATCTTCTTCCAGATAGGAAAAAGAAATTTCAGACCCGCGT       GCACAGAAAGACTTTAAATCCTCTATTTGATGAAACTTTTCAATTTCCTGTAGCATATGATCAACTAA       GCAACCGAAAACTACATTTCAGTGTGTATGATTTTGACAGATTTTCTAGACATGACATGATTGGGGAA       GTGATTCTTGATAATTTGTTTGAAGTCTCTGATCTCTCCAGGGAAGCCACAGTATGGAAAGATATTCA       CTGTGCTACCACAGAAAGTATAGACCTGGGTGAAATCATGTTTTCCCTTTGTTACCTACCGACGGCTG       GGCGTATGACATTGACAGTCATTAAGTGCAGAAATCTGAAGGCGATGGATATTACTGGCTCATCAGAT       CCTTATGTCAAAGTGTTCCTGATGTGTGAAGGTCGAAGATTAAAAAAGAGGAAAACAACTACAAAGAA       AAACACTCTAAACCCTGTGTACAATGAGGCCATTATTTTTGACATCCCTCCAGAGAACGTGGACCAGG       TCAGCCTCTCCATTGCGGTCATGGATTACGATAGGGTAGGACACAATGAGGTCATAGGAGTGTGCAGA       ACAGGACTGGATGCTGAGGGTCTTGGGCGAGACCACTGGAATGAAATGCTGGCCTATCATCGAAAACC       AATAACGCACTGGCACCCATTGCTGGAGTTACCTGGCCGGGCGACCAGTTTTGATAGTCAAGGATCCT       GCCCTTCTCCTAAACCACCTTCCACACCA TAA   TGC                                           NOV44a, CG56959-02   SEQ ID NO: 1006   523 aa   MW at 59186.2kD           Protein Sequence                     MSFHKEDGVNSLCQKALHIVTELCFAGQVEWEKCSGIFPRDRGSQGGSSTDISVSLLAVVVSFCGLAL           LVVSLFVFWKLCWPCWKSKPVTSNITTLPQSISSAPTEVFETEEKKEIKENEKPAVKAIEPAIKISHT       SPDIPAEVQTALKEHLIKHARVQRQITEPTSSTRHSSFRRHLPRQMQVSSVDFSMGTEPVLQRGETTT       SIGRIKPELYKQKSVDSEGNQNEDVKICGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTSDPYVK       MYLLPDRKKKFQTRVHRKTLNPLFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVILDNLFE       VSDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGPMTLTVIKCRNLKAMDITGSSDPYVKVFLM       CEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGL       GRDHWNEMLAYHRKPITHWHPLLELPGRATSFDSQGSCPSPKPPSTP                                     NOV44b, CG56959-01   SEQ ID NO: 1007   1697 bp           DNA Sequence   ORF Start: ATG at 78   ORF Stop: TAA at 1647                       CAGAGGGGTTAGAGGTACGGGAAGAGGAAAAGACGGCTAACTGGGAAAAAAAGAGAAAACGAAAGAAA               AGCCAAACG   ATG AGTTTCCACAAGGAGGACGGAGTGAACAGTCTGTGCCAGAAGGCTCTGCACATCGT       CACCGAGCTGTGCTTCGCCGGCCAGGTGGAGTGGGAGAAGTGCTCGGGCATCTTCCCTCGGGACAGGG       GCAGCCAGGGCGGAAGCAGCACAGATATTTCAGTCAGCCTGTTAGCTGTCGTTGTCAGCTTTTGTGGA       CTGGCCTTGTTGGTTGTCTCACTTTTTGTCTTCTGGAAGCTGTGTTGGCCATGCTGGAAAAGCAAACC       TGTGACTTCCAACATCACTACGCTTCCACAGAGCATTTCAAGTGCTCCTACTGAAGTTTTTGAGACTG       AAGAGAAAAAAGAAATTAAGGAAAATGAAAAGCCAGCCGTAAAAGCTATTGAGCCTGCAATAAAAATC       AGCCACACTTCCCCTGACATCCCAGCAGAAGTCCAAACTGCTTTAAAAGAACATTTAATTAAACATGC       ACGTGTGCAAAGACAAATTACTGAGCCTACGTCATCAACCCGGCACAGTTCCTTCCGAAGACACCTGC       CGAGGCAAATGCAGGTTTCCAGTGTTGATTTTAGCATGGGCACAGAACCTGTTTTACAACGAGGAGAA       ACAACAACCAGCATTGGGAGGATAAAGCCAGAACTCTACAAACAGAAATCAGTTGACTCTGAGGGCAA       CCAAAACGAAGATGTCAAAATCTGTGGGAAACTTAACTTTACCCTCCAGTATGATTATGAAAATGAAC       TTCTAGTTGTTAAAATTATCAAAGCTTTAGATCTCCCTGCTAAAGACTTCACAGGAACTTCTGACCCT       TATGTGAAGATGTATCTTCTTCCAGATAGGAAAAAGAAATTTCAGACCCGCGTGCACAGAAAGACTTT       AAATCCTCTATTTGATGAAACTTTTCAATTTCCTGTAGCATATGATCAACTAAGCAACCGAAAACTAC       ATTTCAGTGTGTATGATTTTGACAGATTTTCTAGACATGACATGATTGGGGAAGTGATTCTTGATAAT       TTGTTTGAAGTCTCTGATCTCTCCAGGGAAGCCACAGTATGGAAAGATATTCACTGTGCTACCACAGA       AAGTATAGACCTGGGTGAAATCATGTTTTCCCTTTGTTACCTACCGACGGCTGGGCGTATGACATTGA       CAGTCATTAAGTGCAGAAATCTGAAGGCGATGGATATTACTGGCTCATCAGATCCTTATGTCAAAGTG       TCCCTGATGTGTGAAGGTCGAAGATTAAAAAAGAGGAAAACAACTACAAAGAAAAACACTCTAAACCC       TGTGTACAATGAGGCCATTATTTTTGACATCCCTCCAGAGAACGTGGACCAGGTCAGCCTCTCCATTG       CGGTCATGGATTACGATAGGGTAGGACACAATGAGGTCATAGGAGTGTGCAGAACAGGACTGGATGCT       GAGGGTCTTGGGCGAGACCACTGGAATGAAATGCTGGCCTATCATCGAAAACCAATAACGCACTGGCA       CCCATTGCTGGAGTTACCTGGCCGGGCGACCAGTTTTGATAGTCAAGGATCCTGCCCTTCTCCTAAAC       CACCTTCCACACCA TAA   TGCCTCCAAAATGAGACCATGATATTAAGCATCTAGGATCACGTGCTC                                           NOV44b, CG56959-01   SEQ ID NO: 1008   523 aa   MW at 59126.1kD           Protein Sequence                     MSFHKEDGVNSLCQKALHIVTELCFAGQVEWEKCSGIFPRDRGSQGGSSTDISVSLLAVVVSFCGLAL           LVVSLFVFWKLCWPCWKSKPVTSNITTLPQSISSAPTEVFETEEKKEIKENEKPAVKAIEPAIKISHT       SPDIPAEVQTALKEHLIKHARVQRQITEPTSSTRHSSFRRHLPRQMQVSSVDFSMGTEPVLQRGETTT       SIGRIKPELYKQKSVDSEGNQNEDVKICGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTSDPYVK       MYLLPDRKKKFQTRVHRKTLNPLFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVILDNLFE       VSDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLM       CEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGL       GRDHWNEMLAYHRKPITHWHPLLELPGRATSFDSQGSCPSPKPPSTP                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 44B.  
               TABLE 44B                       Comparison of the NOV44 protein sequences.                                            NOV44a   MSFHKEDGVNSLCQKALHIVTELCFAGQVEWEKCSGIFPRDRGSQGGSSTDISVSLLAVV           NOV44b   MSFHKEDGVNSLCQKALHIVTELCFAGQVEWEKCSGIFPRDRGSQGGSSTDISVSLLAVV               NOV44a   VSFCGLALLVVSLFVFWKLCWPCWKSKPVTSNITTLPQSISSAPTEVFETEEKKEIKENE       NOV44b   VSFCGLALLVVSLFVFWKLCWPCWKSKPVTSNITTLPQSISSAPTEVFETEEKKEIKENE               NOV44a   KPAVKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQRQITEPTSSTRHSSFRRHLPR       NOV44b   KPAVKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQRQITEPTSSTRHSSFRRHLPR               NOV44a   QMQVSSVDFSMGTEPVLQRGETTTSIGRIKPELYKQKSVDSEGNQNEDVKICGKLNFTLQ       NOV44b   QMQVSSVDFSMGTEPVLQRGETTTSIGRIKPELYKQKSVDSEGNQNEDVKICGKLNFTLQ               NOV44a   YDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLLPDRKKKFQTRVHRKTLNPLFDETF       NOV44b   YDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLLPDRKKKFQTRVHRKTLNPLFDETF               NOV44a   QFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVILDNLFEVSDLSREATVWKDIHCATTE       NOV44b   QFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVILDNLFEVSDLSREATVWKDIHCATTE               NOV44a   SIDLGEIMFSLCYLPTAGRMTLTVIKCFNLKAMDITGSSDPYVKVFLMCEGPRLKKRKTT       NOV44b   SIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGPRLKKRKTT               NOV44a   TKKNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDH       NOV44b   TKKNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDH               NOV44a   WNEMLAYHRKPITHWHPLLELPGRATSFDSQGSCPSPKPPSTP       NOV44b   WNEMLAYHRKPITHWHPLLELPGRATSFDSQGSCPSPKPPSTP               NOV44a   (SEQ ID NO: 1006)       NOV44b   (SEQ ID NO: 1008)                  
 
      Further analysis of the NOV44a protein yielded the following properties shown in Table 44C.  
               TABLE 44C                       Protein Sequence Properties NOV44a                                        SignalP analysis:   Cleavage site between residues 32 and 33       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 7; pos. chg 1; neg. chg 2           H-region:   length 7; peak value 0.00           PSG score:   −4.40                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −7.65           possible cleavage site: between 28 and 29                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 59-75               −11.36                             PERIPHERAL   Likelihood = 4.35 (at 247)                         ALOM score: −11.36 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 66           Charge difference: 3.0 C(3.0)-N(0.0)           C &gt; N: C-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 1b (cytoplasmic tail 59 to 523)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   5.17           Hyd Moment(95):   1.90   G content:   0           D/E content:   2   S/T content:   1                         Score: −7.37       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: RKKK (5) at 279           pat4: KKRK (5) at 415           pat7: PDRKKKF (5) at 277           bipartite: none           content of basic residues: 12.6%           NLS Score: 0.58       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: found                         LL at 68           LL at 247           LL at 275           LL at 498                 checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 55.5       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         39.1%: nuclear           26.1%: cytoplasmic           13.0%: mitochondrial            8.7%: vesicles of secretory system            4.3%: vacuolar            4.3%: peroxisomal            4.3%: endoplasmic reticulum                 &gt;&gt; prediction for CG56959-02 is nuc (k = 23)                  
 
      A search of the NOV44a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 44D.  
               TABLE 44D                          Geneseq Results for NOV44a                                         NOV44a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               ABJ04645   Protein of NOVX 6 SEQ ID No 12 -   1 . . . 523   522/523 (99%)   0.0           Unidentified, 523 aa. [WO200246409-   1 . . . 523   522/523 (99%)           A2, 13-JUN-2002]       AAO19183   Human neurotransmission-associated   1 . . . 523   521/533 (97%)   0.0           protein NTRAN6 -  Homo sapiens , 533   1 . . . 533   522/533 (97%)           aa. [WO200266646-A2, 29-AUG-2002]       ABP47935   Human polypeptide SEQ ID NO 365 -   78 . . . 501    296/424 (69%)   e−176             Homo sapiens , 461 aa.   33 . . . 450    348/424 (81%)           [US2002042386-A1, 11-APR-2002]       AAU19715   Human novel extracellular matrix   78 . . . 501    296/424 (69%)   e−176           protein, Seq ID No 365 -  Homo     33 . . . 450    348/424 (81%)             sapiens , 461 aa. [WO200155368-A1,           02-AUG-2001]       ABP69319   Human polypeptide SEQ ID NO 1366 -   84 . . . 501    291/418 (69%)   e−172             Homo sapiens , 425 aa.   3 . . . 414   343/418 (81%)           [WO200270539-A2, 12-SEP-2002]                  
 
      In a BLAST search of public sequence databases, the NOV44a protein was found to have homology to the proteins shown in the BLASTP data in Table 44E.  
               TABLE 44E                          Public BLASTP Results for NOV44a                                         NOV44a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q925B8   Synaptotagmin 10 -  Rattus     1 . . . 523   487/523 (93%)   0.0             norvegicus  (Rat), 523 aa.   1 . . . 523   502/523 (95%)       Q9R0N4   Synaptotagmin X (SytX) -  Mus     1 . . . 523   485/523 (92%)   0.0             musculus  (Mouse), 523 aa.   1 . . . 523   501/523 (95%)       O08625   Synaptotagmin X (SytX) -  Rattus     1 . . . 498   462/498 (92%)   0.0             norvegicus  (Rat), 498 aa   1 . . . 498   477/498 (95%)           (fragment).       Q9R0N8   Synaptotagmin VI -  Mus musculus     13 . . . 501    329/496 (66%)   0.0           (Mouse), 511 aa.   12 . . . 500    391/496 (78%)       Q62746   Synaptotagmin VI -  Rattus     13 . . . 501    329/496 (66%)   0.0             norvegicus  (Rat), 511 aa.   12 . . . 500    389/496 (78%)                  
 
      PFam analysis predicts that the NOV44a protein contains the domains shown in the Table 44F.  
               TABLE 44F                          Domain Analysis of NOV44a                                             Identities/                       Similarities           Pfam   NOV44a   for the   Expect           Domain   Match Region   Matched Region   Value                       C2   248 . . . 334   44/89 (49%)   6.2e−39                   83/89 (93%)           C2   380 . . . 468   38/90 (42%)   1.6e−35                   78/90 (87%)                      
 
     Example 45  
      The NOV45 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 45A.  
               TABLE 45A                       NOV45 Sequence Analysis                                                NOV45a, CG57111-01   SEQ ID NO: 1009   2855 bp           DNA Sequence   ORF Start: at 3   ORF Stop: TGA at 2844                       GA GGGAATGCGCGCAGCTCACAGGCCCTGGGAGTGAGCTGGTGCCCGGCGACCTGGCACCCGCGCCTG           GATATGGGGCGTCTACATCGTCCCAGGAGCAGCACCAGCTACAGGAACCTGCCGCATCTGTTTCTGTT       TTTCCTCTTCGTGGGACCCTTCAGCTGCCTCGGGAGTTACAGCCGGGCCACCGAGCTTCTGTACAGCC       TAAACGAGGGACTACCCGCGGGGGTGCTCATCGGCAGCCTGGCCGAGGACCTGCGGCTGCTGCCCAGG       TCTGCAGGGAGGCCGGACCCGCAGTCGCAGCTGCCAGAGCGCACCGGTGCTGAGTGGAACCCCCCTCT       CTCCTTCAGCCTGGCCTCCCGGGGACTGAGTGGCCAGTACGTGACCCTAGACAACCGCTCTGGGGAGC       TGCACACTTCAGCTCAGGAGATCGACAGGGAGGCCCTGTGTGTTGAAGGGGGTGGAGGGACTGCGTGG       AGCGGCAGCGTTTCCATCTCCTCCTCTCCTTCTGACTCTTGTCTTTTGCTGCTGGATGTGCTTGTCCT       GCCTCAGGAATACTTCAGGTTTGTGAAGGTGAAGATCGCCATCAGAGACATCAATGACAACGCCCCGC       AGTTCCCTGTTTCCCAGATCTCGGTGTGGGTCCCGGAAAATGCACCTGTAAACACCCGACTGGCCATA       GAGCATCCTGCTGTGGACCCAGATGTTGGCATTAATGGGGTTCAGACCTATCGCTTACTGGACTACCA       TGGTATGTTCACCCTGGACGTGGAGGAGAATGAGAATGGGGAGCGCACCCCCTACCTAATTGTCATGG       GTGCTTTGGACAGGGAAACCCAGGACCAGTATGTGAGCATCATCACAGCTGAGGATGGTGGGTCTCCA       CCACTTTTGGGCAGTGCCACTCTCACCATTGGCATCAGTGACATTAATGACAATTGCCCTCTCTTCAC       AGACTCACAAATCAATGTCACTGTGTATGGGAATGCTACAGTGGGCACCCCAATTGCAGCTGTCCAGG       CTGTGGATAAAGACTTGGGGACCAATGCTCAAATTACTTATTCTTACAGTCAGAAAGTTCCACAAGCA       TCTAAGGATTTATTTCACCTGGATGAAAACACTGGAGTCATTAAACTTTTCAGTAAGATTGGAGGAAG       TGTTCTGGAGTCCCACAAGCTCACCATCCTTGCTAATGGACCAGGCTGCATCCCTGCTGTAATCACTG       CTCTTGTGTCCATTATTAAAGTTATTTTCAGACCCCCTGAAATTGTCCCTCGTTACATAGCAAACGAG       ATAGATGGTGTTGTTTATCTGAAAGAACTGGAACCCGTTAACACTCCCATTGCGTTTTTCACCATAAG       AGATCCAGAAGGTAAATACAAGGTTAACTGCTACCTGGATGGTGAAGGGCCGTTTAGGTTATCACCTT       ACAAACCATACAATAATGAATATTTACTAGAGACCACAAAACCTATGGACTATGAGCTACAGCAGTTC       TATGAAGTAGCTGTGGTGGCTTGGAACTCTGAGGGATTTCATGTCAAAAGGGTCATTAAAGTGCAACT       TTTAGATGACAATGATAATGCTCCAATTTTCCTTCAACCCTTAATAGAACTAACCATCGAAGAGAACA       ACTCACCCAATGCCTTTTTGACTAAGCTGTATGCTACAGATGCCGACAGCGAGGAGAGAGGCCAAGTT       TCATATTTTCTGGGACCTGATGCTCCATCATATTTTTCCTTAGACAGTGTCACAGGAATTCTGACAGT       TTCTACTCAGCTGGACCGAGAAGAGAAAGAAAAGTACAGATACACTGTCAGAGCTGTTGACTGTGGGA       AGCCACCCAGAGAATCAGTAGCCACTGTGGCCCTCACAGTGTTGGATAAAAATGACAACAGTCCTCGG       TTTATCAACAAGGACTTCAGCTTTTTTGTGCCTGAAAACTTTCCAGGCTATGGTGAGATTGGAGTAAT       TAGTGTAACAGATGCTGACGCTGGACGAAATGGATGGGTCGCCCTCTCTGTGGTGAACCAGAGTGATA       TTTTTGTCATAGATACAGGAAAGGGTATGCTGAGGGCTAAAGTCTCTTTGGACAGAGAGCAGCAAAGC       TCCTATACTTTGTGGGTTGAAGCTGTTGATGGGGGTGAGCCTGCCCTCTCCTCTACAGCAAAAATCAC       AATTCTCCTTCTAGATATCAATGACAACCCTCCTCTTGTTTTGTTTCCTCAGTCTAATATGTCTTATC       TGTTAGTACTGCCTTCTACTCTGCCAGGCTCCCCGGTTACAGAAGTCTATGCTGTCGACAAAGACACA       GGCATGAATGCTGTCATAGCTTACAGCATCATAGGGAGAAGAGGTCCTAGGCCTGAGTCCTTCAGGAT       TGACCCTAAAACTGGCAACATTACTTTGGAAGAGGCATTGCTGCAGACAGATTATGGGCTCCATCGCT       TACTGGTGAAAGTGAGTGATCATGGTTATCCCGAGCCTCTCCACTCCACAGTCATGGTGAACCTATTT       GTCAATGACACTGTCAGTAATGAGAGTTACATTGAGAGTCTTTTAAGAAAAGAACCAGAGATTAATAT       AGAGGAGAAAGAACCACAAATCTCAATAGAACCGACTCATAGGAAGGTAGAATCTGTGTCTTGTATGC       CCACCTTAGTAGCTCTGTCTGTAATAAGCTTGGGTTCCATCACACTGGTCACAGGGATGGGCATATAC       ATCTGTTTAAGGAAAGGGGAAAAGCATCCCAGGGAAGATGAAAATTTGGAAGTACAGATTCCACTGAA       AGGAAAAATTGACTTGCATATGCGAGAGAGAAAGCCAATGGATATTTCTAATATT TGA   TATTTCATG                                           NOV45a, CG57111-01   SEQ ID NO: 1010   947 aa   MW at 104405.1kD           Protein Sequence                     GNARSSQALGVSWCPATWHPRLDMGRLHRPRSSTSYRNLPHLFLFFLFVGPFSCLGSYSRATELLYSL           NEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLSGQYVTLDNRSGEL       HTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQ       FPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMG       ALDRETQDQYVSIITAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQA       VDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITA       LVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPY       KPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENN       SPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGK       PPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDI       FVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYL       LVLPSTLPGSPVTEVYAVDKDTGNNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRL       LVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSCMP       TLVALSVISLGSITLVTGMGIYICLRKGEKHPREDENLEVQIPLKGKIDLHMRERKPMDISNI                                     NOV45b, 277726328   SEQ ID NO: 1011   2854 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       G GGATCCGGGAATGCGCGCAGCTCACAGGCCCTGGGAGTGAGCTGGTGCCCGGCGACCTGGCACCCGC           GCCTGGATATGGGGCGTCTACATCGTCCCAGGAGCAGCACCAGCTACAGGAACCTGCCGCATCTGTTT       CTGTTTTTCCTCTTCGTGGGACCCTTCAGCTGCCTCGGGAGTTACAGCCGGGCCACCGAGCTTCTGTA       CAGCCTAAACGAGGGACTACCCGCGGGGGTGCTCATCGGCAGCCTGGCCGAGGACCTGCGGCTGCTGC       CCAGGTCTGCAGGGAGGCCGGACCCGCAGTCGCAGCTGCCAGAGCGCACCGGTGCTGAGTGGAACCCC       CCTCTCTCCTTCAGCCTGGCCTCCCGGGGACTGAGTGGCCAGTACGTGACCCTAGACAACCGCTCTGG       GGAGCTGCACACTTCAGCTCAGGAGATCGACAGGGAGGCCCTGTGTGTTGAAGGGGGTGGAGGGACTG       CGTGGAGCGGCAGCGTTTCCATCTCCTCCTCTCCTTCTGACTCTTGTCTTTTGCTGCTGGATGTGCTT       GTCCTGCCTCAGGAATACTTCAGGTTTGTGAAGGTGAAGATCGCCATCAGAGACATCAATGACAACGC       CCCGCAGTTCCCTGTTTCCCAGATCTCGGTGTGGGTCCCGGAAAATGCACCTGTAAACACCCGACTGG       CCATAGAGCATCCTGCTGTGGACCCAGATGTAGGCATTAATGGGGTACAGACCTATCGCTTACTGGAC       TACCATGGTATGTTCACCCTGGACGTGGAGGAGAATGAGAATGGGGAGCGCACCCCCTACCTAATTGT       CATGGGTGCTTTGGACAGGGAAACCCAGGACCAGTATGTGAGCATCATCATAGCTGAGGATGGTGGGT       CTCCACCACTTTTGGGCAGTGCCACTCTCACCATTGGCATCAGTGACATTAATGACAATTGCCCTCTC       TTCACAGACTCACAAATCAATGTCACTGTGTATGGGAATGCTACAGTGGGCACCCCAATTGCAGCTGT       CCAGGCTGTGGATAAAGACTTGGGGACCAATGCTCAAATTACTTATTCTTACAGTCAGAAAGTTCCAC       AAGCATCTAAGGATTTATTTCACCTGGATGAAAACACTGGAGTCATTAAACTTTTCAGTAAGATTGGA       GGAAGTGTTCTGGAGTCCCACAAGCTCACCATCCTTGCTAATGGACCAGGCTGCATCCCTGCTGTAAT       CACTGCTCTTGTGTCCATTATTAAAGTTATTTTCAGACCCCCTGAAATTGTCCCTCGTTACATAGCAA       ACGAGATAGATGGTGTTGTTTATCTGAAAGAACTGGAACCCGTTAACACTCCCATTGCGTTTTTCACC       ATAAGAGATCCAGAAGGTAAATACAAGGTTAACTGCTACCTGGATGGTGAAGGGCCGTTTAGGTTATC       ACCTTACAAACCATACAATAATGAATATTTACTAGAGACCACAAAACCTATGGACTATGAGCTACAGC       AGTTCTATGAAGTAGCTGTGGTGGCTTGGAACTCTGAGGGATTTCATGTCAAAAGGGTCATTAAAGTG       CAACTTTTAGATGACAATGATAATGCTCCAATTTTCCTTCAACCCTTAATAGAACTAACCATCGAAGA       GAACAACTCACCCAATGCCTTTTTGACTAAGCTGTATGCTACAGATGCCGACAGCGAGGAGAGAGGCC       AAGTTTCATATTTTCTGGGACCTGATGCTCCATCATATTTTTCCTTAGACAGTGTCACAGGAATTCTG       ACAGTTTCTACTCAGCTGGACCGAGAAGAGAAAGAAAAGTACAGATACACTGTCAGAGCTGTTGACTG       TGGGAAGCCACCCAGAGAATCAGTAGCCACTGTGGCCCTCACAGTGTTGGATAAAAATGACAACAGTC       CTCGGTTTATCAACAAGGACTTCAGCTTTTTTGTGCCTGAAAACTTTCCAGGCTATGGTGAGATTGGA       GTAATTAGTGTAACAGATGCTGACGCTGGACGAAATGGATGGGTCGCCCTCTCTGTGGTGAACCAGAG       TGGTATTTTTGTCATAGATACAGGAAAGGGTATGCTGAGGGCTAAAGTCTCTTTGGACAGAGAGCAGC       AAAGCTCCTATACTTTGTGGGTTGAAGCTGTTGATGGGGGTGAGCCTGCCCTCTCCTCTACAGCAAAA       ATCACAATTCTCCTTCTAGATATCAATGACAACCCTCCTCTTGTTTTGTTTCCTCAGTCTAATATGTC       TTATCTGTTAGTACTGCCTTCTACTCTGCCAGGCTCCCCGGTTACAGAAGTCTATGCTGTCGACAAAG       ACACAGGCATGAATGCTGTCATAGCTTACAGCATCATAGGGAGAAGAGGTCCTAGGCCTGAGTCCTTC       AGGATTGACCCTAAAACTGGCAACATTACTTTGGAAGAGGCATTGCTGCAGACAGATTATGGGCTCCA       TCGCTTACTGGTGAAAGTGAGTGATCATGGTTATCCCGAGCCTCTCCACTCCACAGTCATGGTGAACC       TATTTGTCAATGACACTGTCAGTAATGAGAGTTACATTGAGAGTCTTTTAAGAAAAGAACCAGAGATT       AATATAGAGGAGAAAGAACCACAAATCTCAATAGAACCGACTCATAGGAAGGTAGAATCTGTGTCTTG       TATGCCCACCTTAGTAGCTCTGTCTGTAATAAGCTTGGGTTCCATCACACTGGTCACAGGGATGGGCA       TATACATCTGTTTAAGGAAAGGGGAAAAGCATCCCAGGGAAGATGAAAATTTGGAAGTACAGATTCCA       CTGAAAGGAAAAATTGACTTGCATATGCGAGAGAGAAAGCCAATGGATATTTCTAATATTCTCGAG                                         NOV45b, 277726328   SEQ ID NO: 1012   951 aa   MW at 104745.6kD           Protein Sequence                     GSGNARSSQALGVSWCPATWHPRLDMGRLHRPRSSTSYRNLPHLFLFFLFVGPFSCLGSYSRATELLY           SLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLSGQYVTLDNRSG       ELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEYFRFVKVKIAIRDINDNA       PQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIV       MGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAV       QAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVI       TALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLS       PYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEE       NNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDC       GKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQS       GIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMS       YLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLH       RLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSC       MPTLVALSVISLGSITLVTGMGIYICLRKGEKHPREDENLEVQIPLKGKIDLHMRERKPMDISNILE                                     NOV45c, CG57111-02   SEQ ID NO: 1013   1020 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     AGTTACAGCCGGGCCACCGAGCTTCTGTACAGCCTAAACGAGGGACTACCCGCGGGGGTGCTCATCGG           CAGCCTGGCCGAGGACCTGCGGCTGCTGCCCAGGTCTGCAGGGAGGCCGGACCCGCAGTCGCAGCTGC       CAGAGCGCACCGGTGCTGAGTGGAACCCCCCTCTCTCCTTCAGCCTGGCCTCCCGGGGACTGAGTGGC       CAGTACGTGACCCTAGACAACCGCTCTGGGGAGCTGCACACTTCAGCTCAGGAGATCGACAGGGAGGC       CCTGTGTGTTGAAGGGGGTGGAGGGACTGCGTGGAGCGGCAGCGTTTCCATCTCCTCCTCTCCTTCTG       ACTCTTGTCTTTTGCTGCTGGATGTGCTTGTCCTGCCTCAGGAATACTTCAGGTTTGTGAAGGTGAAG       ATCGCCATCAGAGACATCAATGACAACGCCCCGCAGTTCCCTGTTTCCCAGATCTCGGTGTGGGTCCC       GGAAAATGCACCTGTAAACACCCGACTGGCCATAGAGCATCCTGCTGTGGACCCAGATGTAGGCATTA       ATGGGGTGCAGACCTATCGCTTACTGGACTACCATGGTATGTTCACCCTGGACGTGGAGGAGAATGAG       AATGGGGAGCGCACCCCCTACCTAATTGTCATGGGTGCTTTGGACAGGGAAACCCAGGACCAGTATGT       GAGCATCATCATAGCTGAGGATGGTGGGTCTCCACCACTTTTGGGCAGTGCCACTCTCACCATTGGCA       TCAGTGACATTAATGACAATTGCCCTCTCTTCACAGACTCACAAATCAATGTCACTGTGTATGGGAAT       GCTACAGTGGGCACCCCAATTGCAGCTGTCCAGGCTGTGGATAAAGACTTGGGGACCAATGCTCAAAT       TACTTATTCTTACAGTCAGAAAGTTCCACAAGCATCTAAGGATTTATTTCACCTGGATGAAAACACTG       GAGTCATTAAACTTTTCAGTAAGATTGGAGGAAGTGTTCTGGAGTCCCACAAGCTCACCATCCTTGCT                                         NOV45c, CG57111-02   SEQ ID NO: 1014   340 aa   MW at 36598.6kD           Protein Sequence                     SYSRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLSG           QYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEYFRFVKVK       IAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENE       NGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGN       ATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILA                                     NOV45d, CG57111-03   SEQ ID NO: 1015   1032 bp           DNA Sequence   ORF Start: at 7   ORF Stop: at 1027                       GGATCC AGTTACAGCCGGGCCACCGAGCTTCTGTACAGCCTAAACGAGGGACTACCCGCGGGGGTGCT           CATCGGCAGCCTGGCCGAGGACCTGCGGCTGCTGCCCAGGTCTGCAGGGAGGCCGGACCCGCAGTCGC       AGCTGCCAGAGCGCACCGGTGCTGAGTGGAACCCCCCTCTCTCCTTCAGCCTGGCCTCCCGGGGACTG       AGTGGCCAGTACGTGACCCTAGACAACCGCTCTGGGGAGCTGCACACTTCAGCTCAGGAGATCGACAG       GGAGGCCCTGTGTGTTGAAGGGGGTGGAGGGACTGCGTGGAGCGGCAGCGTTTCCATCTCCTCCTCTC       CTTCTGACTCTTGTCTTTTGCTGCTGGATGTGCTTGTCCTGCCTCAGGAATACTTCAGGTTTGTGAAG       GTGAAGATCGCCATCAGAGACATCAATGACAACGCCCCGCAGTTCCCTGTTTCCCAGATCTCGGTGTG       GGTCCCGGAAAATGCACCTGTAAACACCCGACTGGCCATAGAGCATCCTGCTGTGGACCCAGATGTAG       GCATTAATGGGGTGCAGACCTATCGCTTACTGGACTACCATGGTATGTTCACCCTGGACGTGGAGGAG       AATGAGAATGGGGAGCGCACCCCCTACCTAATTGTCATGGGTGCTTTGGACAGGGAAACCCAGGACCA       GTATGTGAGCATCATCATAGCTGAGGATGGTGGGTCTCCACCACTTTTGGGCAGTGCCACTCTCACCA       TTGGCATCAGTGACATTAATGACAATTGCCCTCTCTTCACAGACTCACAAATCAATGTCACTGTGTAT       GGGAATGCTACAGTGGGCACCCCAATTGCAGCTGTCCAGGCTGTGGATAAAGACTTGGGGACCAATGC       TCAAATTACTTATTCTTACAGTCAGAAAGTTCCACAAGCATCTAAGGATTTATTTCACCTGGATGAAA       ACACTGGAGTCATTAAACTTTTCAGTAAGATTGGAGGAAGTGTTCTGGAGTCCCACAAGCTCACCATC       CTTGCTCTC GAG                                           NOV45d, CG57111-03   SEQ ID NO: 1016   340 aa   MW at 36598.6kD           Protein Sequence                     SYSRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLSG           QYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEYFRFVKVK       IAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENE       NGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGN       ATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILA                                     NOV45e, CG57111-04   SEQ ID NO: 1017   1390 bp           DNA Sequence   ORF Start: at 8   ORF Stop: at 1385                       GGGATCC CCTGAAATTGTCCCTCGTTACATAGCAAACGAGATAGATGGTGTTGTTTATCTGAAAGAAC           TGGAACCCGTTAACACTCCCATTGCGTTTTTCACCATAAGAGATCCAGAAGGTAAATACAAGGTTAAC       TGCTACCTGGATGGTGAAGGGCCGTTTAGGTTATCACCTTACAAACCATACAATAATGAATATTTACT       AGAGACCACAAAACCTATGGACTATGAGCTACAGCAGTTCTATGAAGTAGCTGTGGTGGCTTGGAACT       CTGAGGGATTTCATGTCAAAAGGGTCATTAAAGTGCAACTTTTAGATGACAATGATAATGCTCCAATT       TTCCTTCAACCCTTAATAGAACTAACCATCGAAGAGAACAACTCACCCAATGCCTTTTTGACTAAGCT       GTATGCTACAGATGCCGACAGCGAGGAGAGAGGCCAAGTTTCATATTTTCTGGGACCTGATGCTCCAT       CATATTTTTCCTTAGACAGTGTCACAGGAATTCTGACAGTTTCTACTCAGCTGGACCGAGAAGAGAAA       GAAAAGTACAGATACACTGTCAGAGCTGTTGACTGTGGGAAGCCACCCAGAGAATCAGTAGCCACTGT       GGCCCTCACAGTGTTGGATAAAAATGACAACAGTCCTCGGTTTATCAACAAGGACTTCAGCTTTTTTG       TGCCTGAAAACTTTCCAGGCTATGGTGAGATTGGAGTAATTAGTGTAACAGATGCTGACGCTGGACGA       AATGGATGGGTCGCCCTCTCTGTGGTGAACCAGAGTGATATTTTTGTCATAGATACAGGAAAGGGTAT       GCTGAGGGCTAAAGTCTCTTTGGACAGAGAGCAGCAAAGCTCCTATACTTTGTGGGTTGAAGCTGTTG       ATGGGGGTGAGCCTGCCCTCTCCTCTACAGCAAAAATCACAATTCTCCTTCTAGATATCAATGACAAC       CCTCCTCTTGTTTTGTTTCCTCAGTCTAATATGTCTTATCTGTTAGTACTGCCTTCTACTCTGCCAGG       CTCCCCGGTTACAGAAGTCTATGCTGTCGACAAAGACACAGGCATGAATGCTGTCATAGCTTACAGCA       TCATAGGGAGAAGAGGTCCTAGGCCTGAGTCCTTCAGGATTGACCCTAAAACTGGCAACATTACTTTG       GAAGAGGCATTGCTGCAGACAGATTATGGGCTCCATCGCTTACTGGTGAAAGTGAGTGATCATGGTTA       TCCCGAGCCTCTCCACTCCACAGTCATGGTGAACCTATTTGTCAATGACACTGTCAGTAATGAGAGTT       ACATTGAGAGTCTTTTAAGAAAAGAACCAGAGATTAATATAGAGGAGAAAGAACCACAAATCTCAATA       GAACCGACTCATAGGAAGGTAGAACTCGAG                                         NOV45e, CG57111-04   SEQ ID NO: 1018   459 aa   MW at 51489.5kD           Protein Sequence                     PEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEYLLET           TKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYA       TDADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVAL       TVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLR       AKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSP       VTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPE       PLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVE                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 45B.  
               TABLE 45B                       Comparison of the NOV45 protein sequences.                                            NOV45a   --GNARSSQALGVSWCPATWHPRLDMGRLHRPRSSTSYRNLPHLFLFFLFVGPFSCLGSY           NOV45b   GSGNARSSQALGVSWCPATWHPRLDMGRLHRPRSSTSYRNLPHLFLFFLFVGPFSCLGSY       NOV45c   ----------------------------------------------------------SY       NOV45d   ----------------------------------------------------------SY       NOV45e   -------------------------------------------PEIVPRYIANEIDGVVY               NOV45a   SRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLA       NOV45b   SRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLA       NOV45c   SRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLA       NOV45d   SRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLA       NOV45e   LKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQ               NOV45a   SRGLSGQYVTLDN---------------------------------RSGELHTSAQEIDR       NOV45b   SRGLSGQYVTLDN---------------------------------RSGELHTSAQEIDR       NOV45c   SRGLSGQYVTLDN---------------------------------RSGELHTSAQEIDR       NOV45d   SRGLSGQYVTLDN---------------------------------RSGELHTSAQEIDR       NOV45e   QFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYAT               NOV45a   EALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEYFR------------------       NOV45b   EALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEYFR------------------       NOV45c   EALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEYFR------------------       NOV45d   EALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEYFR------------------       NOV45e   DADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRE               NOV45a   -FVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLL       NOV45b   -FVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLL       NOV45c   -FVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLL       NOV45d   -FVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLATEHPAVDPDVGINGVQTYRLL       NOV45e   SVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVIS-VTDADAGRNGWVALSVV               NOV45a   DYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIITAEDGGSPPLLGSATLTIGI       NOV45b   DYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGI       NOV45c   DYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGI       NOV45d   DYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGI       NOV45e   NQSDIFVIDTGKG-------MLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILL               NOV45a   SDINDNCPLFTDSQIN---VTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQAS       NOV45b   SDINDNCPLFTDSQIN---VTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQAS       NOV45c   SDINDNCPLFTDSQIN---VTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQAS       NOV45d   SDINDNCPLFTDSQIN---VTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQAS       NOV45e   LDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRR-GPR               NOV45a   KDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIV       NOV45b   KDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIV       NOV45c   KDLFHLDENTGVIKLFSKIGGSVLESHKLTILA---------------------------       NOV45d   KDLFHLDENTGVIKLFSKIGGSVLESHKLTILA---------------------------       NOV45e   PESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNES               NOV45a   PRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEY       NOV45b   PRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEY       NOV45c   ------------------------------------------------------------       NOV45d   ------------------------------------------------------------       NOV45e   YIESLLRKEPEINIEEKEPQISIEPTHRKVE-----------------------------               NOV45a   LLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEEN       NOV45b   LLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEEN       NOV45c   ------------------------------------------------------------       NOV45d   ------------------------------------------------------------       NOV45e   ------------------------------------------------------------               NOV45a   NSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRY       NOV45b   NSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRY       NOV45c   ------------------------------------------------------------       NOV45d   ------------------------------------------------------------       NOV45e   ------------------------------------------------------------               NOV45a   TVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDAD       NOV45b   TVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDAD       NOV45c   ------------------------------------------------------------       NOV45d   ------------------------------------------------------------       NOV45e   ------------------------------------------------------------               NOV45a   AGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAK       NOV45b   AGRNGWVALSVVNQSGIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAK       NOV45c   ------------------------------------------------------------       NOV45d   ------------------------------------------------------------       NOV45e   ------------------------------------------------------------               NOV45a   ITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGR       NOV45b   ITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGR       NOV45c   ------------------------------------------------------------       NOV45d   ------------------------------------------------------------       NOV45e   ------------------------------------------------------------               NOV45a   RGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTV       NOV45b   RGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTV       NOV45c   ------------------------------------------------------------       NOV45d   ------------------------------------------------------------       NOV45e   ------------------------------------------------------------               NOV45a   SNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSCMPTLVALSVISLGSITLVTGM       NOV45b   SNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSCMPTLVALSVISLGSITLVTGM       NOV45c   ------------------------------------------------------------       NOV45d   ------------------------------------------------------------       NOV45e   ------------------------------------------------------------               NOV45a   GIYICLRKGEKHPREDENLEVQIPLKGKIDLHMRERKPMDISNI--       NOV45b   GIYICLRKGEKHPREDENLEVQIPLKGKIDLHMRERKPMDISNILE       NOV45c   ----------------------------------------------       NOV45d   ----------------------------------------------       NOV45e   ----------------------------------------------               NOV45a   (SEQ ID NO: 1010)       NOV45b   (SEQ ID NO: 1012)       NOV45c   (SEQ ID NO: 1014)       NOV45d   (SEQ ID NO: 1016)       NOV45e   (SEQ ID NO: 1018)                  
 
      Further analysis of the NOV45a protein yielded the following properties shown in Table 45C.  
               TABLE 45C                       Protein Sequence Properties NOV45a                                        SignalP analysis:   Cleavage site between residues 57 and 58       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 4; pos. chg 1; neg. chg 0           H-region:   length 16; peak value 6.44           PSG score:   2.04                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −0.42           possible cleavage site: between 56 and 57                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 56)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 57           Tentative number of TMS(s) for the threshold 0.5: 2                                 INTEGRAL   Likelihood =   Transmembrane 401-417               −7.38           INTEGRAL   Likelihood =   Transmembrane 886-902               −3.77                             PERIPHERAL   Likelihood = 2.01 (at 173)                         ALOM score: −7.38 (number of TMSs: 2)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 28           Charge difference: 0.5 C(3.5)-N(3.0)           C &gt; N: C-terminal side will be inside                 &gt;&gt;&gt;Caution: Inconsistent mtop result with signal peptide       &gt;&gt;&gt; membrane topology: type 3b                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   2   Hyd Moment(75):   3.38           Hyd Moment(95):   4.41   G content:   2           D/E content:   1   S/T content:   4                         Score: −3.49       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 70 SRA|TE                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 8.6%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: NARS       none                 SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: GNARSS       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 76.7       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         44.4%: endoplasmic reticulum           11.1%: Golgi           11.1%: vacuolar           11.1%: mitochondrial           11.1%: nuclear           11.1%: cytoplasmic                 &gt;&gt; prediction for CG57111-01 is end (k = 9)                  
 
      A search of the NOV45a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 45D.  
               TABLE 45D                          Geneseq Results for NOV45a                                         NOV45a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               ABP70119   Human NOV32a -  Homo sapiens , 947   1 . . . 947    947/947 (100%)   0.0           aa. [WO200272771-A2, 19-SEP-2002]   1 . . . 947    947/947 (100%)       ABU52605   Human NOVX protein, NOV16a -   1 . . . 947   946/947 (99%)   0.0             Homo sapiens , 962 aa.   16 . . . 962    946/947 (99%)           [WO200281518-A2, 17-OCT-2002]       AAU09958   Human cadherin-1 (CDHN-1) protein -   24 . . . 947    923/924 (99%)   0.0             Homo sapiens , 924 aa.   1 . . . 924   923/924 (99%)           [WO200179293-A2, 25-OCT-2001]       ABP47865   Human polypeptide SEQ ID NO 295 -   551 . . . 947    396/397 (99%)   0.0             Homo sapiens , 397 aa.   1 . . . 397   397/397 (99%)           [US2002042386-A1, 11-APR-2002]       AAU19645   Human novel extracellular matrix   551 . . . 947    396/397 (99%)   0.0           protein, Seq ID No 295 -  Homo     1 . . . 397   397/397 (99%)             sapiens , 397 aa. [WO200155368-A1,           02-AUG-2001]                  
 
      In a BLAST search of public sequence databases, the NOV45a protein was found to have homology to the proteins shown in the BLASTP data in Table 45E.  
               TABLE 45E                          Public BLASTP Results for NOV45a                                          NOV45a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q9NRT9   Protocadherin 13 -  Homo sapiens     1 . . . 947    947/947 (100%)   0.0           (Human), 947 aa (fragment).   1 . . . 947    947/947 (100%)       Q8NDN4   Hypothetical protein -  Homo     1 . . . 947   946/947 (99%)   0.0             sapiens  (Human), 951 aa.   5 . . . 951   946/947 (99%)       Q8N6Y1   Protocadherin 20 -  Homo sapiens     24 . . . 947    923/924 (99%)   0.0           (Human), 924 aa.   1 . . . 924   923/924 (99%)       Q8BIV2   PROTOCADHERIN 13 homolog -   1 . . . 947   874/948 (92%)   0.0             Mus musculus  (Mouse), 952 aa.   5 . . . 952   910/948 (95%)       Q8BIZ0   PROTOCADHERIN 13 homolog -   24 . . . 947    860/925 (92%)   0.0             Mus musculus  (Mouse), 925 aa.   1 . . . 925   896/925 (95%)                  
 
      PFam analysis predicts that the NOV45a protein contains the domains shown in the Table 45F.  
               TABLE 45F                          Domain Analysis of NOV45a                                     Identities/               NOV45a   Similarities for   Expect       Pfam Domain   Match Region   the Matched Region   Value               cadherin   210 . . . 307   36/111 (32%)   2.5e−08               72/111 (65%)       cadherin   321 . . . 413   27/110 (25%)   0.0004               66/110 (60%)       cadherin   536 . . . 626   33/107 (31%)   6.4e−19               69/107 (64%)       cadherin   640 . . . 729   39/107 (36%)   5.8e−20               69/107 (64%)       cadherin   747 . . . 840   38/112 (34%)     4e−11               70/112 (62%)                  
 
     Example 46  
      The NOV46 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 46A.  
               TABLE 46A                       NOV46 Sequence Analysis                                                NOV46a, CG57409-05   SEQ ID NO: 1019   1500 bp           DNA Sequence   ORF Start: ATG at 12   ORE Stop: TGA at 1476                       TGAGCCGAGAC   ATG AGCGGGACCTACCGCTGCCAGACGGCCCGCTATAATGGCTTCAACGTGCGCCCC           CGTGAGGCCCAGGTGCAGCTGAACGTGCAGTTCCCGCCGGAGGTGGAGCCCAGTTCCCAGGACGTGCG       CCAGGCGCTGGGCCGGCCCGTGCTCCTGCGCTGCTCGCTGCTGCGAGGCAGCCCCCAGCGCATCGCCT       CGGCTGTGTGGCGTTTCAAAGGGCAGCTGCTGCCGCCGCCGCCTGTTGTTCCCGCCGCCGCCGAGGCG       CCGGATCACGCGGAGCTGCGCCTCGACGCCGTAACTCGCGACAGCAGCGGCAGCTACGAGTGCAGCGT       CTCCAACGATGTGGGCTCGGCTGCCTGCCTCTTCCAGGTCTCCGCCAAAGCCTACAGCCCGGAGTTTT       ACTTCGACACCCCCAACCCCACCCGCAGCCACAAGCTGTCCAAGAACTACTCCTACGTGCTGCAGTGG       ACTCAGAGGGAGCCCGACGCTGTCGACCCTGTGCTCAACTACAGACTCAGCATCCGCCAGTTGAACCA       GCACAATGCGGTGGTCAAGGCCATCCCGGTCCGGCGTGTGGAGAAGGGGCAGCTGCTGGAGTACATCC       TGACCGATCTCCGTGTGCCCCACAGCTATGAGGTCCGCCTCACACCCTATACCACCTTCGGGGCTGGT       GACATGGCCTCCCGCATCATCCACTACACAGAGCGCCAGATCCGCTGGCCCCCAGTCCTGGCTCTGAG       GACCCTGTCCTCTGGTCCCAAGCAGGGTATCCTCTGCAGAGCCCCACACCTCAGTTCTGACTTGGTTT       CCCCGCTTGCTTTCTCAGCCATCAACTCTCCGAACCTTTCAGACAACACCTGCCACTTTGAGGATGAG       AAGATCTGTGGCTATACCCAGGACCTGACAGACAACTTTGACTGGACGCGGCAGAATGCCCTCACCCA       GAACCCCAAACGCTCCCCCAACACTGGTCCCCCCACCGACATAAGTGGCACCCCTGAGGGCTACTACA       TGTTCATCGAGACATCGAGGCCTCGGGAGCTGGGGGACCGTGCAAGGTTAGTGAGTCCCCTCTACAAT       GCCAGCGCCAAGTTCTACTGTGTCTCCTTCTTCTACCACATGTACGGGAAACACATCGGCTCCCTCAA       CCCCCTGGTGCGGTCCCGGAACAAAGGGGCTCTGGACACGCACGCCTGGTCTCTCAGTGGCAATAAGG       GCAATGTGTGGCAGCAGGCCCATGTGCCCATCAGCCCCAGTGGGCCCTTCCAGATTATTTTTGAGGGG       GTTCGAGGCCCGGGCTACCTGGGGGATATTGCCATAGATGACGTCACACTGAAGAAGGGGGAGTGTCC       CCGGAAGCAGACGGATCCCAATAAAGTGGTGGTGATGCCGGGCAGTGGAGCCCCCTGCCAGTCCAGCC       CACAGCTGTGGGGGCCCATGGCCATCTTCCTCTTGGCGTTGCAGAGA TGA   TGAGAGCTGTGTGGCCAC           CCCC                                       NOV46a, CG57409-05   SEQ ID NO: 1020   488 aa   MW at 54357.1kD       Protein Sequence                     MSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW           RFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDT       PNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDL       RVPHSYEVRLTPYTTFGAGDMASRIIHYTERQIRWPPVLALRTLSSGPKQGILCRAPHLSSDLVSPLA       FSAINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIE       TSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNPLVRSRNKGALDTHAWSLSGNKGNVW       QQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQTDPNKVVVMPGSGAPCQSSPQLW       GPMAIFLLALQR                                     NOV46b, 277731446   SEQ ID NO: 1021   1363 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGTACCATGAGCGGGACCTACCGCTGCCAGACGGCCCGCTATAATGGCTTCAACGTGCGCCCCC           GTGAGGCCCAGGTGCAGCTGAACGTGCAGTTCCCGCCGGAGGTGGAGCCCAGTTCCCAGGACGTGCGC       CAGGCGCTGGGCCGGCCCGTGCTCCTGCGCTGCTCGCTGCTGCGAGGCAGCCCCCAGCGCATCGCCTC       GGCTGTGTGGCGTTTCAAAGGGCAGCTGCTGCCGCCGCCGCCTGTTGTTCCCGCCGCCGCCGAGGCGC       CGGATCACGCGGAGCTGCGCCTCGACGCCGTAACTCGCGACAGCAGCGGCAGCTACGAGTGCAGCGTC       TCCAACGATGTGGGCTCGGCTGCCTGCCTCTTCCAGGTCTCCGCCAAAGCCTACAGCCCGGAGTTTTA       CTTCGACACCCCCAACCCCACCCGCAGCCACAAGCTGTCCAAGAACTACTCCTACGTGCTGCAGTGGA       CTCAGAGGGAGCCCGACGCTGTCGACCCTGTGCTCAACTACAGACTCAGCATCCGCCAGTTGAACCAG       CACAATGCGGTGGTCAAGGCCATCCCGGTCCGGCGTGTGGAGAAGGGGCAGCTGCTGGAGTACATCCT       GACCGATCTCCGTGTGCCCCACAGCTATGAGGTCCGCCTCACACCCTATACCACCTTCGGGGCTGGTG       ACATGGCCTCCCGCATCATCCACTACACAGAGCCCATCAACTCTCCGAACCTTTCAGACAACACCTGC       CACTTTGAGGATGAGAAGATCTGTGGCTATACCCAGGACCTGACAGACAACTTTGACTGGACGCGGCA       GAATGCCCTCACCCAGAACCCCAAACGCTCCCCCAACACTGGTCCCCCCACCGACATAAGTGGCACCC       CTGAGGGCTACTACATGTTCATCGAGACATCGAGGCCTCGGGAGCTGGGGGACCGTGCAAGGTTAGTG       AGTCCCCTCTACAATGCCAGCGCCAAGTTCTACTGTGTCTCCTTCTTCTACCACATGTACGGGAAACA       CATCGGCTCCCTCAACCTCCTGGTGCGGTCCCGGAACAAAGGGGCTCTGGACACGCACGCCTGGTCTC       TCAGTGGCAATAAGGGCAATGTGTGGCAGCAGGCCCATGTGCCCATCAGCCCCAGTGGGCCCTTCCAG       ATTATTTTTGAGGGGGTTCGAGGCCCGGGCTACCTGGGGGATATTGCCATAGATGACGTCACACTGAA       GAAGGGGGAGTGTCCCCGGAAGCAGACGGATCCCAATAAAGTGGTGGTGATGCCGGGCAGTGGAGCCC       CCTGCCAGTCCAGCCCACAGCTGTGGGGGCCCATGGCCATCTTCCTCTTGGCGTTGCAGAGACTCGAG       GGC                                         NOV46b, 277731446   SEQ ID NO: 1022   454 aa   MW at 50606.7kD           Protein Sequence                     TGTMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIAS           AVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFY       FDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYIL       TDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQ       NALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKH       IGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLK       KGECPRKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQRLEG                                     NOV46c, CG57409-07   SEQ ID NO: 1023   1363 bp           DNA Sequence   ORF Start: ATG at 11   ORF Stop: at 1355                       CACCGGTACC   ATG AGCGGGACCTACCGCTGCCAGACGGCCCGCTATAATGGCTTCAACGTGCGCCCCC           GTGAGGCCCAGGTGCAGCTGAACGTGCAGTTCCCGCCGGAGGTGGAGCCCAGTTCCCAGGACGTGCGC       CAGGCGCTGGGCCGGCCCGTGCTCCTGCGCTGCTCGCTGCTGCGAGGCAGCCCCCAGCGCATCGCCTC       GGCTGTGTGGCGTTTCAAAGGGCAGCTGCTGCCGCCGCCGCCTGTTGTTCCCGCCGCCGCCGAGGCGC       CGGATCACGCGGAGCTGCGCCTCGACGCCGTAACTCGCGACAGCAGCGGCAGCTACGAGTGCAGCGTC       TCCAACGATGTGGGCTCGGCTGCCTGCCTCTTCCAGGTCTCCGCCAAAGCCTACAGCCCGGAGTTTTA       CTTCGACACCCCCAACCCCACCCGCAGCCACAAGCTGTCCAAGAACTACTCCTACGTGCTGCAGTGGA       CTCAGAGGGAGCCCGACGCTGTCGACCCTGTGCTCAACTACAGACTCAGCATCCGCCAGTTGAACCAG       CACAATGCGGTGGTCAAGGCCATCCCGGTCCGGCGTGTGGAGAAGGGGCAGCTGCTGGAGTACATCCT       GACCGATCTCCGTGTGCCCCACAGCTATGAGGTCCGCCTCACACCCTATACCACCTTCGGGGCTGGTG       ACATGGCCTCCCGCATCATCCACTACACAGAGCCCATCAACTCTCCGAACCTTTCAGACAACACCTGC       CACTTTGAGGATGAGAAGATCTGTGGCTATACCCAGGACCTGACAGACAACTTTGACTGGACGCGGCA       GAATGCCCTCACCCAGAACCCCAAACGCTCCCCCAACACTGGTCCCCCCACCGACATAAGTGGCACCC       CTGAGGGCTACTACATGTTCATCGAGACATCGAGGCCTCGGGAGCTGGGGGACCGTGCAAGGTTAGTG       AGTCCCCTCTACAATGCCAGCGCCAAGTTCTACTGTGTCTCCTTCTTCTACCACATGTACGGGAAACA       CATCGGCTCCCTCAACCTCCTGGTGCGGTCCCGGAACAAAGGGGCTCTGGACACGCACGCCTGGTCTC       TCAGTGGCAATAAGGGCAATGTGTGGCAGCAGGCCCATGTGCCCATCAGCCCCAGTGGGCCCTTCCAG       ATTATTTTTGAGGGGGTTCGAGGCCCGGGCTACCTGGGGGATATTGCCATAGATGACGTCACACTGAA       GAAGGGGGAGTGTCCCCGGAAGCAGACGGATCCCAATAAAGTGGTGGTGATGCCGGGCAGTGGAGCCC       CCTGCCAGTCCAGCCCACAGCTGTGGGGGCCCATGGCCATCTTCCTCTTGGCGTTGCAGAGACTC GAG           GGC                                           NOV46c, CG57409-07   SEQ ID NO: 1024   448 aa   MW at 50048.1kD           Protein Sequence                     MSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW           RFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDT       PNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDL       RVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNAL       TQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGS       LNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGE       CPRKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQR                                     NOV46d, 312102874   SEQ ID NO: 1025   1369 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAAGCTTCCCACCATGAGCGGGACCTACCGCTGCCAGACGGCCCGCTATAATGGCTTCAACGTGC           GCCCCCGTGAGGCCCAGGTGCAGCTGAACGTGCAGTTCCCGCCGGAGGTGGAGCCCAGTTCCCAGGAC       GTGCGCCAGGCGCTGGGCCGGCCCGTGCTCCTGCGCTGCTCGCTGCTGCGAGGCAGCCCCCAGCGCAT       CGCCTCGGCTGTGTGGCGTTTCAAAGGGCAGCTGCTGCCGCCGCCGCCTGTTGTTCCCGCCGCCGCCG       AGGCGCCGGATCACGCGGAGCTGCGCCTCGACGCCGTAACTCGCGACAGCAGCGGCAGCTACGAGTGC       AGCGTCTCCAACGATGTGGGCTCGGCTGCCTGCCTCTTCCAGGTCTCCGCCAAAGCCTACAGCCCGGA       GTTTTACTTCGACACCCCCAACCCCACCCGCAGCCACAAGCTGTCCAAGAACTACTCCTACGTGCTGC       AGTGGACTCAGAGGGAGCCCGACGCTGTCGACCCTGTGCTCAACTACAGACTCAGCATCCGCCAGTTG       AACCAGCACAATGCGGTGGTCAAGGCCATCCCGGTCCGGCGTGTGGAGAAGGGGCAGCTGCTGGAGTA       CATCCTGACCGATCTCCGTGTGCCCCACAGCTATGAGGTCCGCCTCACACCCTATACCACCTTCGGGG       CTGGTGACATGGCCTCCCGCATCATCCACTACACAGAGCCCATCAACTCTCCGAACCTTTCAGACAAC       ACCTGCCACTTTGAGGATGAGAAGATCTGTGGCTATACCCAGGACCTGACAGACAACTTTGACTGGAC       GCGGCAGAATGCCCTCACCCAGAACCCCAAACGCTCCCCCAACACTGGTCCCCCCACCGACATAAGTG       GCACCCCTGAGGGCTACTACATGTTCATCGAGACATCGAGGCCTCGGGAGCTGGGGGACCGTGCAAGG       TTAGTGAGTCCCCTCTACAATGCCAGCGCCAAGTTCTACTGTGTCTCCTTCTTCTACCACATGTACGG       GAAACACATCGGCTCCCTCAACCTCCTGGTGCGGTCCCGGAACAAAGGGGCTCTGGACACGCACGCCT       GGTCTCTCAGTGGCAATAAGGGCAATGTGTGGCAGCAGGCCCATGTGCCCATCAGCCCCAGTGGGCCC       TTCCAGATTATTTTTGAGGGGGTTCGAGGCCCGGGCTACCTGGGGGATATTGCCATAGATGACGTCAC       ACTGAAGAAGGGGGAGTGTCCCCGGAAGCAGACGGATCCCAATAAAGTGGTGGTGATGCCGGGCAGTG       GAGCCCCCTGCCAGTCCAGCCCACAGCTGTGGGGGCCCATGGCCATCTTCCTCTTGGCGTTGCAGAGA       GAATTCGGC                                         NOV46d, 312102874   SEQ ID NO: 1026   456 aa   MW at 50922.1kD           Protein Sequence                     TKLPTMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRI           ASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPE       FYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKATPVRRVEKGQLLEY       ILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWT       RQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYG       KHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVT       LKKGECPRKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQREFG                                     NOV46e, 312102899   SEQ ID NO: 1027   1249 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAAGCTTAGCGGGACCTACCGCTGCCAGACGGCCCGCTATAATGGCTTCAACGTGCGCCCCCGTG           AGGCCCAGGTGCAGCTGAACGTGCAGTTCCCGCCGGAGGTGGAGCCCAGTTCCCAGGACGTGCGCCAG       GCGCTGGGCCGGCCCGTGCTCCTGCGCTGCTCGCTGCTGCGAGGCAGCCCCCAGCGCATCGCCTCGGC       TGTGTGGCGTTTCAAAGGGCAGCTGCTGCCGCCGCCGCCTGTTGTTCCCGCCGCCGCCGAGGCGCCGG       ATCACGCGGAGCTGCGCCTCGACGCCGTAACTCGCGACAGCAGCGGCAGCTACGAGTGCAGCGTCTCC       AACGATGTGGGCTCGGCTGCCTGCCTCTTCCAGGTCTCCGCCAAAGCCTACAGCCCGGAGTTTTACTT       CGACACCCCCAACCCCACCCGCAGCCACAAGCTGTCCAAGAACTACTCCTACGTGCTGCAGTGGACTC       AGAGGGAGCCCGACGCTGTCGACCCTGTGCTCAACTACAGACTCAGCATCCGCCAGTTGAACCAGCAC       AATGCGGTGGTCAAGGCCATCCCGGTCCGGCGTGTGGAGAAGGGGCAGCTGCTGGAGTACATCCTGAC       CGATCTCCGTGTGCCCCACAGCTATGAGGTCCGCCTCACACCCTATACCACCTTCGGGGCTGGTGACA       TGGCCTCCCGCATCATCCACTACACAGAGCCCATCAACTCTCCGAACCTTTCAGACAACACCTGCCAC       TTTGAGGATGAGAAGATCTGTGGCTATACCCAGGACCTGACAGACAACTTTGACTGGACGCGGCAGAA       TGCCCTCACCCAGAACCCCAAACGCTCCCCCAACACTGGTCCCCCCACCGACATAAGTGGCACCCCTG       AGGGCTACTACATGTTCATCGAGACATCGAGGCCTCGGGAGCTGGGGGACCGTGCAAGGTTAGTGAGT       CCCCTCTACAATGCCAGCGCCAAGTTCTACTGTGTCTCCTTCTTCTACCACATGTACGGGAAACACAT       CGGCTCCCTCAACCTCCTGGTGCGGTCCCGGAACAAAGGGGCTCTGGACACGCACGCCTGGTCTCTCA       GTGGCAATAAGGGCAATGTGTGGCAGCAGGCCCATGTGCCCATCAGCCCCAGTGGGCCCTTCCAGATT       ATTTTTGAGGGGGTTCGAGGCCCGGGCTACCTGGGGGATATTGCCATAGATGACGTCACACTGAAGAA       GGGGGAGTGTCCCCGGGAATTCGGC                                         NOV46e, 312102899   SEQ ID NO: 1028   416 aa   MW at 46644.0kD           Protein Sequence                     TKLSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASA           VWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYF       DTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILT       DLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQN       ALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHI       GSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKK       GECPREFG                                     NOV46f, CG57409-01   SEQ ID NO: 1029   4141 bp           DNA Sequence   ORF Start: ATG at 135   ORF Stop: at 4140                       TCTTCGTCGCCGCTCTCTCTCTCACCTCTCAGGGAAAGGGGGGGACATAGGGGCGTCGCGGGGCCCCC               GCGAATGCGCCCCCCGCCGCCTCTCGGGCTGCGCCGCCTCGCGGGGATGAAGCACCGGCCGTGAAG   AT           G GAGGTGACCTGCCTTCTACTTCTGGCGCTGATCCCCTTCCACTGCCGGGGACAAGGAGTCTACGCTC       CAGCCCAGGCGCAGATCGTGCATGCGGGCCAGGCATGTGTGGTGAAAGAGGACAATATCAGCGAGCGT       GTCTACACCATCCGGGAGGGGGACACCCTCATGCTGCAGTGCCTTGTAACAGGGCACCCTCGACCCCA       GGTACGGTGGACCAAGACGGCAGGTAGCGCCTCGGACAAGTTCCAGGAGACATCGGTGTTCAACGAGA       CGCTGCGCATCGAGCGTATTGCACGCACGCAGGGCGGCCGCTACTACTGCAAGGCTGAGAACGGCGTG       GGGGTGCCGGCCATCAAGTCCATCCGCGTGGACGTGCAGTACCTGGATGAGCCAATGCTGACGGTGCA       CCAGACGGTGAGCGATGTGCGAGGCAACTTCTACCAGGAGAAGACGGTGTTCCTGCGCTGTACTGTCA       ACTCCAACCCGCCTGCCCGCTTCATCTGGAAGCGGGGTTCCGATACCCTATCCCACAGCCAGGACAAT       GGGGTTGACATCTATGAGCCCCTCTACACTCAGGGGGAGACCAAGGTCCTGAAGCTGAAGAACCTGCG       GCCCCAGGACTATGCCAGCTACACCTGCCAGGTGTCTGTGCGTAACGTGTGCGGCATCCCAGACAAGG       CCATCACCTTCCGGCTCACCAACACCACGGCACCACCAGCCCTGAAGCTGTCTGTGAACGAAACTCTG       GTGGTGAACCCTGGGGAGAATGTGACGGTGCAGTGTCTGCTGACAGGCGGTGATCCCCTCCCCCAGCT       GCAGTGGTCCCATGGGCCTGGCCCACTGCCCCTGGGTGCTCTGGCCCAGGGTGGCACCCTCAGCATCC       CTTCAGTGCAGGCCCGGGACTCTGGCTACTACAACTGCACAGCCACCAACAATGTGGGCAACCCTGCC       AAGAAGACTGTCAACCTGCTGGTGCGATCCATGAAGAACGCTACATTCCAGATCACTCCTGACGTGAT       CAAAGAGAGTGAGAACATCCAGCTGGGCCAGGACCTGAAGCTATCGTGCCACGTGGATGCAGTGCCCC       AGGAGAAGGTGACCTACCAGTGGTTCAAGAATGGCAAGCCGGCACGCATGTCCAAGCGGCTGCTGGTG       ACCCGCAATGATCCTGAGCTGCCCGCAGTCACCAGCAGCCTAGAGCTCATTGACCTGCACTTCAGTGA       CTATGGCACCTACCTGTGCATGGCTTCTTTCCCAGGGGCACCCGTGCCCGACCTCAGCGTCGAGGTCA       ACATCTCCTCTGAGACAGTGCCGCCCACCATCAGTGTGCCCAAGGGTAGGGCCGTGGTGACCGTGCGC       GAGGGATCGCCTGCCGAGCTGCAATGCGAGGTGCGGGGCAAGCCGCGGCCGCCAGTGCTCTGGTCCCG       CGTGGACAAGGAGGCTGCACTGCTGCCCTCGGGGCTGCCCCTGGAGGAGACTCCGGACGGGAAGCTGC       GGCTGGAGCGAGTGAGCCGAGACATGAGCGGGACCTACCGCTGCCAGACGGCCCGCTATAATGGCTTC       AACGTGCGCCCCCGTGAGGCCCAGGTGCAGCTGAACGTGCAGTTCCCGCCGGAGGTGGAGCCCAGTTC       CCAGGACGTGCGCCAGGCGCTGGGCCGGCCCGTGCTCCTGCGCTGCTCGCTGCTGCGAGGCAGCCCCC       AGCGCATCGCCTCGGCTGTGTGGCGTTTCAAAGGGCAGCTGCTGCCGCCGCCGCCTGTTGTTCCCGCC       GCCGCCGAGGCGCCGGATCACGCGGAGCTGCGCCTCGACGCCGTAACTCGCGACAGCAGCGGCAGCTA       CGAGTGCAGCGTCTCCAACGATGTGGGCTCGGCTGCCTGCCTCTTCCAGGTCTCCGCCAAAGCCTACA       GCCCGGAGTTTTACTTCGACACCCCCAACCCCACCCGCAGCCACAAGCTGTCCAAGAACTACTCCTAC       GTGCTGCAGTGGACTCAGAGGGAGCCCGACGCTGTCGACCCTGTGCTCAACTACAGACTCAGCATCCG       CCAGTTGAACCAGCACAATGCGGTGGTCAAGGCCATCCCGGTCCGGCGTGTGGAGAAGGGGCAGCTGC       TGGAGTACATCCTGACCGATCTCCGTGTGCCCCACAGCTATGAGGTCCGCCTCACACCCTATACCACC       TTCGGGGCTGGTGACATGGCCTCCCGCATCATCCACTACACAGAGCGCCAGATCCGCTGGCCCCCAGT       CCTGGCTCTGAGGACCCTGTCCTCTGGTCCCAAGCAGGGTATCCTCTGCAGAGCCCCACACCTCAGTT       CTGACTTGGTTTCCCCGCTTGCTTTCTCAGCCATCAACTCTCCGAACCTTTCAGACAACACCTGCCAC       TTTGAGGATGAGAAGATCTGTGGCTATACCCAGGACCTGACAGACAACTTTGACTGGACGCGGCAGAA       TGCCCTCACCCAGAACCCCAAACGCTCCCCCAACACTGGTCCCCCCACCGACATAAGTGGCACCCCTG       AGGGCTACTACATGTTCATCGAGACATCGAGGCCTCGGGAGCTGGGGGACCGTGCAAGGTTAGTGAGT       CCCCTCTACAATGCCAGCGCCAAGTTCTACTGTGTCTCCTTCTTCTACCACATGTACGGGAAACACAT       CGGCTCCCTCAACCTCCTGGTGCGGTCCCGGAACAAAGGGGCTCTGGACACGCACGCCTGGTCTCTCA       GTGGCAATAAGGGCAATGTGTGGCAGCAGGCCCATGTGCCCATCAGCCCCAGTGGGCCCTTCCAGATT       ATTTTTGAGGGGGTTCGAGGCCCGGGCTACCTGGGGGATATTGCCATAGATGACGTCACACTGAAGAA       GGGGGAGTGTCCCCGGAAGCAGACGGATCCCAATAAAGGTGCAAGACGGGAAGGAGCTGCCTGCGATG       GCCTGAAATTCCACCTTTCATCCCCTATGGATGACGGAGAGCTTACAGATGACCCTATTGAATGCAAG       CACCTTTGGATCCATAGAGTGGACAGTAAAGGTGCTCAGTACATGTTGGCTGAGCTGAACTGCATACA       TGTGGCCCCCAGGTTCCTGGTCTTTATGGACGAAGGGCACAAGGTTGGTGAAAAGGACTCCGGGGGCC       AGCCCTTCCAAGTTTACACTGATTTCTCCTTTTACCCTCATGCTATCCCTGAGAAGATGTCAATAATG               CCCACGTTACAGGTGGGAAAACTGAGGCTTAGAGAGGAGGAGGAATCTGCCTACGGTCACACAGCTGC       AAAGGCTAGAGCTGGGACCAGGAGCTGGTCTCTTAACCGACCACCTGAGCTCAAGAGCTTTTCTCTCT       GGACCAACATGACCCAAAGTGTGCGCGAGCCTATCACAGGTCCCCTGCAATGCCAAACATACACGCAC       AGCAATACACAACACCTGGGGACATGGATGAAGCTGGAAACCATCATTCTCAGCAAACTGACACAAGA       ACAGAAAACCAAACACCACATGTTCTCACTCACCACCCAGTCTGCCCCGCCCTCTCTCTTCTCACCTG       AACTTCCCCTCTCCTCAAACTCTCGAGGCCACGCCTCTATGTCCTTGGATGATGATGATGACGACGAC       GACGATGATGATGATGATGATGACGACGATGACAATGATGATGATGATGGAAGGAAGACCTACAGAAT       CCCTCCAGGCTCTGACCTCAGTGCTTGTGGGTGGGTGAATGACCACATGTCGCAGGGAGACTCCACAG       GTCCTCCCGATGAGAAGCACTCTTATGCCAAAGAGGAGACTCAGGCCAAACTGACAGGACCAGGAATT       AGCTACCCTGGTAAACCCAGCTATCGACTGCACCCGAGCGGCTACACACCACTGGAGCAGTTCAGGGA       GAAAGCCACCGGCATGCTCACCCCGTATGTCTCTGGCTCTGTTTCCTCTTTCTGCTTCCCCTTCCCCA       CCTCTGAGTCTCTGTGTTCTGCTCATGCCAATTCCCCTTCTGCCTGTCTCTGCCCGCTTCT                                         NOV46f, CG57409-01   SEQ ID NO: 1030   1335 aa   MW at 147969.4kD           Protein Sequence                     MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRP           QVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTV       HQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNL       RPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQ       LQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDV       IKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFS       DYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWS       RVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPS       SQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGS       YECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSI       RQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTERQIRWPP       VLALRTLSSGPKQGILCRAPHLSSDLVSPLAFSAINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQ       NALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKH       IGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLK       KGECPRKQTDPNKGARREGAACDGLKFHLSSPMDDGELTDDPIECKHLWIHRVDSKGAQYMLAELNCI       HVAPRFLVFMDEGHKVGEKDSGGQPFQVYTDFSFYPHAIPEKMSIMPTLQVGKLRLREEEESAYGHTA       AKARAGTRSWSLNRPPELKSFSLWTNMTQSVREPITGPLQCQTYTHSNTQHLGTWNKLETIILSKLTQ       EQKTKHHMFSLTTQSAPPSLFSPELPLSSNSRGHASMSLDDDDDDDDDDDDDDDDDDNDDDDGRKTYR       IPPGSDLSACGWVNDHMSQGDSTGPPDEKHSYAKEETQAKLTGPGISYPGKPSYRLHPSGYTPLEQFR       EKATGMLTPYVSGSVSSFCFPFPTSESLCSAHANSPSACLCPL                                     NOV46g, CG57409-02   SEQ ID NO: 1031   720 bp           DNA Sequence   ORF Start: at 7   ORF Stop: at 715                       GGTACC TTGAACCAGCACAATGCGGTGGTCAAGGCCATCCCGGTCCGGCGTGTGGAGAAGGGGCAGCT           GCTGGAGTACATCCTGACCGATCTCCGTGTGCCCCACAGCTATGAGGTCCGCCTCACACCCTATACCA       CCTTCGGGGCTGGTGACATGGCCTCCCGCATCATCCACTACACAGAGCCCATCAACTCTCCGAACCTT       TCAGACAACACCTGCCACTTTGAGGATGAGAAGATCTGTGGCTATACCCAGGACCTGACAGACAACTT       TGACTGGACGCGGCAGAATGCCCTCACCCAGAACCCCAAACGCTCCCCCAACACTGGTCCCCCCACCG       ACATAAGTGGCACCCCTGAGGGCTACTACATGTTCATCGAGACATCGAGGCCTCGGGAGCTGGGGGAC       CGTGCAAGGTTAGTGAGTCCCCTCTACAATGCCTGCGCCAAGTTCTACTGTGTCTCCTTCTTCTACCA       CATGTACGGGAAACACATCGGCTCCCTCAACCTCCTGGTGCGGTCCCGGAACAAAGGGGCTCTGGACA       CGCACGCCTGGTCTCTCAGTGGCAATAAGGGCAATGTGTGGCAGCAGGCCCATGTGCCCATCAGCCCC       AGTGGGCCCTTCCAGATTATTTTTGAGGGGGTTCGAGGCCCGGGCTACCTGGGGGATATTGCCATAGA       TGACGTCACACTGAAGAAGGGGGAGTGTCCCCGGGAA TTC                                           NOV46g, CG57409-02   SEQ ID NO: 1032   236 aa   MW at 26563.7kD           Protein Sequence                     LNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSD           NTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRA       RLVSPLYNACAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSG       PFQIIFEGVRGPGYLGDIAIDDVTLKKGECPR                                     NOV46h, CG57409-03   SEQ ID NO: 1033   4169 bp           DNA Sequence   ORF Start: ATG at 135   ORF Stop: TGA at 4080                       TCTTCGTCGCCGCTCTCTCTCTCACCTCTCAGGGAAAGGGGGGGACATAGGGGCGTCGCGGGGCCCCG               GCGAATGCGCCCCCCGCCGCCTCTCGGGCTGCGCCGCCTCGCGGGGATGAAGCACCGGCCGTGAAG   AT           G GAGGTGACCTGCCTTCTACTTCTGGCGCTGATCCCCTTCCACTGCCGGGGACAAGGAGTCTACGCTC       CAGCCCAGGCGCAGATCGTGCATGCGGGCCAGGCATGTGTGGTGAAAGAGGACAATATCAGCGAGCGT       GTCTACACCATCCGGGAGGGGGACACCCTCATGCTGCAGTGCCTTGTAACAGGGCACCCTCGACCCCA       GGTACGGTGGACCAAGACGGCAGGTAGCGCCTCGGACAAGTTCCAGGAGACATCGGTGTTCAACGAGA       CGCTGCGCATCGAGCGTATTGCACGCACGCAGGGCGGCCGCTACTACTGCAAGGCTGAGAACGGCGTG       GGGGTGCCGGCCATCAAGTCCATCCGCGTGGACGTGCAGTACCTGGATGAGCCAATGCTGACGGTGCA       CCAGACGGTGAGCGATGTGCGAGGCAACTTCTACCAGGAGAAGACGGTGTTCCTGCGCTGTACTGTCA       ACTCCAACCCGCCTGCCCGCTTCATCTGGAAGCGGGGTTCCGATACCCTATCCCACAGCCAGGACAAT       GGGGTTGACATCTATGAGCCCCTCTACACTCAGGGGGAGACCAAGGTCCTGAAGCTGAAGAACCTGCG       GCCCCAGGACTATGCCAGCTACACCTGCCAGGTGTCTGTGCGTAACGTGTGCGGCATCCCAGACAAGG       CCATCACCTTCCGGCTCACCAACACCACGGCACCACCAGCCCTGAAGCTGTCTGTGAACGAAACTCTG       GTGGTGAACCCTGGGGAGAATGTGACGGTGCAGTGTCTGCTGACAGGCGGTGATCCCCTCCCCCAGCT       GCAGTGGTCCCATGGGCCTGGCCCACTGCCCCTGGGTGCTCTGGCCCAGGGTGGCACCCTCAGCATCC       CTTCAGTGCAGGCCCGGGACTCTGGCTACTACAACTGCACAGCCACCAACAATGTGGGCAACCCTGCC       AAGAAGACTGTCAACCTGCTGGTGCGATCCATGAAGAACGCTACATTCCAGATCACTCCTGACGTGAT       CAAAGAGAGTGAGAACATCCAGCTGGGCCAGGACCTGAAGCTATCGTGCCACGTGGATGCAGTGCCCC       AGGAGAAGGTGACCTACCAGTGGTTCAAGAATGGCAAGCCGGCACGCATGTCCAAGCGGCTGCTGGTG       ACCCGCAATGATCCTGAGCTGCCCGCAGTCACCAGCAGCCTAGAGCTCATTGACCTGCACTTCAGTGA       CTATGGCACCTACCTGTGCATGGCTTCTTTCCCAGGGGCACCCGTGCCCGACCTCAGCGTCGAGGTCA       ACATCTCCTCTGAGACAGTGCCGCCCACCATCAGTGTGCCCAAGGGTAGGGCCGTGGTGACCGTGCGC       GAGGGATCGCCTGCCGAGCTGCAATGCGAGGTGCGGGGCAAGCCGCGGCCGCCAGTGCTCTGGTCCCG       CGTGGACAAGGAGGCTGCACTGCTGCCCTCGGGGCTGCCCCTGGAGGAGACTCCGGACGGGAAGCTGC       GGCTGGAGCGAGTGAGCCGAGACATGAGCGGGACCTACCGCTGCCAGACGGCCCGCTATAATGGCTTC       AACGTGCGCCCCCGTGAGGCCCAGGTGCAGCTGAACGTGCAGTTCCCGCCGGAGGTGGAGCCCAGTTC       CCAGGACGTGCGCCAGGCGCTGGGCCGGCCCGTGCTCCTGCGCTGCTCGCTGCTGCGAGGCAGCCCCC       AGCGCATCGCCTCGGCTGTGTGGCGTTTCAAAGGGCAGCTGCTGCCGCCGCCGCCTGTTGTTCCCGCC       GCCGCCGAGGCGCCGGATCACGCGGAGCTGCGCCTCGACGCCGTAACTCGCGACAGCAGCGGCAGCTA       CGAGTGCAGCGTCTCCAACGATGTGGGCTCGGCTGCCTGCCTCTTCCAGGTCTCCGCCAAAGCCTACA       GCCCGGAGTTTTACTTCGACACCCCCAACCCCACCCGCAGCCACAAGCTGTCCAAGAACTACTCCTAC       GTGCTGCAGTGGACTCAGAGGGAGCCCGACGCTGTCGACCCTGTGCTCAACTACAGACTCAGCATCCG       CCAGTTGAACCAGCACAATGCGGTGGTCAAGGCCATCCCGGTCCGGCGTGTGGAGAAGGGGCAGCTGC       TGGAGTACATCCTGACCGATCTCCGTGTGCCCCACAGCTATGAGGTCCGCCTCACACCCTATACCACC       TTCGGGGCTGGTGACATGGCCTCCCGCATCATCCACTACACAGAGCCCATCAACTCTCCGAACCTTTC       AGACAACACCTGCCACTTTGAGGATGAGAAGATCTGTGGCTATACCCAGGACCTGACAGACAACTTTG       ACTGGACGCGGCAGAATGCCCTCACCCAGAACCCCAAACGCTCCCCCAACACTGGTCCCCCCACCGAC       ATAAGTGGCACCCCTGAGGGCTACTACATGTTCATCGAGACATCGAGGCCTCGGGAGCTGGGGGACCG       TGCAAGGTTAGTGAGTCCCCTCTACAATGCCAGCGCCAAGTTCTACTGTGTCTCCTTCTTCTACCACA       TGTACGGGAAACACATCGGCTCCCTCAACCTCCTGGTGCGGTCCCGGAACAAAGGGGCTCTGGACACG       CACGCCTGGTCTCTCAGTGGCAATAAGGGCAATGTGTGGCAGCAGGCCCATGTGCCCATCAGCCCCAG       TGGGCCCTTCCAGATTATTTTTGAGGGGGTTCGAGGCCCGGGCTACCTGGGGGATATTGCCATAGATG       ACGTCACACTGAAGAAGGGGGAGTGTCCCCGGAAGCAGACGGATCCCAATAAAGGTGCAAGACGGGAA       GGAGCTGCCTGCGATGGCCTGAAATTCCACCTTTCATCCCCTATGGATGACGGAGAGCTTACAGATGA       CCCTATTGAATGCAAGCACCTTTGGATCCATAGAGTGGACAGTAAAGGTGCTCAGTACATGTTGGCTG       AGCTGAACTGCATACATGTGGCCCCCAGGTTCCTGGTCTTTATGGACGAAGGGCACAAGGTTGGTGAA       AAGGACTCCGGGGGCCAGCCCTTCCAAGTTTACACTGATTTCTCCTTTTACCCTCATGCTATCCCTGA       GAAGATGTCAATAATGCCCACGTTACAGGTGGGAAAACTGAGGCTTAGAGAGGAGGAGGAATCTGCCT       ACGGTCACACAGCTGCAAAGGCTAGAGCTGGGACCAGGAGCTGGTCTCTTAACCGACCACCTGAGCTC               AAGAGCTTTTCTCTCTGGACCAACATGACCCAAAGTGTGCGCGAGCCTATCACAGGTCCCCTGCAATG       CCAAACATACACGCACAGCAATACACAACACCTGGGGACATGGATGAAGCTGGAAACCATCATTCTCA       GCAAACTGACACAAGAACAGAAAACCAAACACCACATGTTCTCACTCACCACCCAGTCTGCCCCGCCC       TCTCTCTTCTCACCTGAACTTCCCCTCTCCTCAAACTCTCGAGGCCACGCCTCTATGTCCTTGGATGA       TGATGATGACGACGACGACGATGATGATGATGATGATGACGACGATGACAATGATGATGATGATGGAA       GGAAGACCTACAGAATCCCTCCAGGCTCTGACCTCAGTGCTTGTGGGTGGGTGAATGACCACATGTCG       CAGGGAGACTCCACAGGTCCTCCCGATGAGAAGCACTCTTATGCCAAAGAGGAGACTCAGGCCAAACT       GACAGGACCAGGAATTAGCTACCCTGGTAAACCCAGCTATCGACTGCACCCGAGCGGCTACACACCAC       TGGAGCAGTTCAGGGAGAAAGCCACCGGCATGCTCACCCCGTATGTCTCTGGCTCTGTTTCCTCTTTC       TGCTTCCCCTTCCCCACCTCTGAGTCTCTGTGTTCTGCTCATGCCAATTCCCCTTCTGCCTGTCTCTG       CCCGCTTCTCTCTGGGCTGGTCTCTCCGAGACTCTGTTCCCTTGGCTGGCATGCCCTCCACCTCCCC T           GA   TGGTTCAGCAGAGATGAAGCCGGCCTGGCTCATGGGTGTGGGTAATGTACTAGTGCAGGAGAGTGG           TGGGGCCCAGTCTGGGTGCAG                                           NOV46h, CG57409-03   SEQ ID NO: 1034   1315 aa    MW at 145782.9kD           Protein Sequence                     MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRP           QVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTV       HQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNL       RPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQ       LQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDV       IKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFS       DYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWS       RVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPS       SQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGS       YECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSI       RQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNL       SDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGD       RARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISP       SGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQTDPNKGARREGAACDGLKFHLSSPMDDGELTD       DPIECKHLWIHRVDSKGAQYMLAELNCIHVAPRFLVFMDEGHKVGEKDSGGQPFQVYTDFSFYPHAIP       EKMSIMPTLQVGKLRLREEEESAYGHTAAKARAGTRSWSLNRPPELKSFSLWTNMTQSVREPITGPLQ       CQTYTHSNTQHLGTWMKLETIILSKLTQEQKTKHHNFSLTTQSAPPSLFSPELPLSSNSRGHASMSLD       DDDDDDDDDDDDDDDDDNDDDDGRKTYRIPPGSDLSACGWVNDHMSQGDSTGPPDEKHSYAKEETQAK       LTGPGISYPGKPSYRLHPSGYTPLEQFREKATGMLTPYVSGSVSSFCFPFPTSESLCSAHANSPSACL       CPLLSGLVSPRLCSLGWHALHLP                                     NOV46i, CG57409-04   SEQ ID NO: 1035   720 bp           DNA Sequence   ORF Start: at 7   ORF Stop: at 715                       GGATCC TTGAACCAGCACAATGCGGTGGTCAAGGCCATCCCGGTCCGGCGTGTGGAGAAGGGGCAGCT           GCTGGAGTACATCCTGACCGATCTCCGTGTGCCCCACAGCTATGAGGTCCGCCTCACACCCTATACCA       CCTTCGGGGCTGGTGACATGGCCTCCCGCATCATCCACTACACAGAGCCCATCAACTCTCCGAACCTT       TCAGACAACACCTGCCACTTTGAGGATGAGAAGATCTGTGGCTATACCCAGGACCTGACAGACAACTT       TGACTGGACGCGGCAGAATGCCCTCACCCAGAACCCCAAACGCTCCCCCAACACTGGTCCCCCCACCG       ACATAAGTGGCACCCCTGAGGGCTACTACATGTTCATCGAGACATCGAGGCCTCGGGAGCTGGGGGAC       CGTGCAAGGTTAGTGAGTCCCCTCTACAATGCCTGCGCCAAGTTCTACTGTGTCTCCTTCTTCTACCA       CATGTACGGGAAACACATCGGCTCCCTCAACCTCCTGGTGCGGTCCCGGAACAAAGGGGCTCTGGACA       CGCACGCCTGGTCTCTCAGTGGCAATAAGGGCAATGTGTGGCAGCAGGCCCATGTGCCCATCAGCCCC       AGTGGGCCCTTCCAGATTATTTTTGAGGGGGTTCGAGGCCCGGGCTACCTGGGGGATATTGCCATAGA       TGACGTCACACTGAAGAAGGGGGAGTGTCCCCGGCTC GAG                                           NOV46i, CG57409-04   SEQ ID NO: 1036   236 aa   MW at 26563.7kD           Protein Sequence                     LNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSD           NTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRA       RLVSPLYNACAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSG       PFQIIFEGVRGPGYLGDIAIDDVTLKKGECPR                                     NOV46j, CG57409-06   SEQ ID NO: 1037   1828 bp           DNA Sequence   ORF Start: ATG at 12   ORF Stop: TGA at 1521                       TGAGCCGAGAC   ATG AGCGGGACCTACCGCTGCCAGACGGCCCGCTATAATGGCTTCAACGTGCGCCCC           CGTGAGGCCCAGGTGCAGCTGAACGTGCAGTTCCCGCCGGAGGTGGAGCCCAGTTCCCAGGACGTGCG       CCAGGCGCTGGGCCGGCCCGTGCTCCTGCGCTGCTCGCTGCTGCGAGGCAGCCCCCAGCGCATCGCCT       CGGCTGTGTGGCGTTTCAAAGGGCAGCTGCTGCCGCCGCCGCCTGTTGTTCCCGCCGCCGCCGAGGCG       CCGGATCACGCGGAGCTGCGCCTCGACGCCGTAACTCGCGACAGCAGCGGCAGCTACGAGTGCAGCGT       CTCCAACGATGTGGGCTCGGCTGCCTGCCTCTTCCAGGTCTCCGCCAAAGCCTACAGCCCGGAGTTTT       ACTTCGACACCCCCAACCCCACCCGCAGCCACAAGCTGTCCAAGAACTACTCCTACGTGCTGCAGTGG       ACTCAGAGGGAGCCCGACGCTGTCGACCCTGTGCTCAACTACAGACTCAGCATCCGCCAGTTGAACCA       GCACAATGCGGTGGTCAAGGCCATCCCGGTCCGGCGTGTGGAGAAGGGGCAGCTGCTGGAGTACATCC       TGACCGATCTCCGTGTGCCCCACAGCTATGAGGTCCGCCTCACACCCTATACCACCTTCGGGGCTGGT       GACATGGCCTCCCGCATCATCCACTACACAGAGCGCCAGATCCGCTGGCCCCCAGTCCTGGCTCTGAG       GACCCTGTCCTCTGGTCCCAAGCAGGGTATCCTCTGCAGAGCCCCACACCTCAGTTCTGACTTGGTTT       CCCCGCTTGCTTTCTCAGCCATCAACTCTCCGAACCTTTCAGACAACACCTGCCACTTTGAGGATGAG       AAGATCTGTGGCTATACCCAGGACCTGACAGACAACTTTGACTGGACGCGGCAGAATGCCCTCACCCA       GAACCCCAAACGCTCCCCCAACACTGGTCCCCCCACCGACATAAGTGGCACCCCTGAGGGCTACTACA       TGTTCATCGAGACATCGAGGCCTCGGGAGCTGGGGGACCGTGCAAGGTTAGTGAGTCCCCTCTACAAT       GCCAGCGCCAAGTTCTACTGTGTCTCCTTCTTCTACCACATGTACGGGAAACACATCGGCTCCCTCAA       CCCCCTGGTGCGGTCCCGGAACAAAGGGGCTCTGGACACGCACGCCTGGTCTCTCAGTGGCAATAAGG       GCAATGTGTGGCAGCAGGCCCATGTGCCCATCAGCCCCAGTGGGCCCTTCCAGATTATTTTTGAGGGG       GTTCGAGGCCCGGGCTACCTGGGGGATATTGCCATAGATGACGTCACACTGAAGAAGGGGGAGTGTCC       CCGGAAGCAGACGGATCCCAATAAAGGTGCAAGACGGGAAGGAGGTGGGGGAGCTGAATCTGGAGGGA       GCTGTGCGTGGCGGGGGTTCCTGTCTGTTGAGGGAGGGTGTTCGGGTCTGAATAGGGGTTCAGACTGT       CTGATGATGGGAATCAGGTGGCTC TGA   CTGTGTTAACGTGTGCCCACAACTCACGTCAGGCTGAGAAC           TGGTGTAACACCATGAGAAAGCTTGGCCCCCACCATCGTGATGAGCATACCGACCTGGTCACCGGAAC           ACAAACACCAACAACCACAGAGGGCGCCTCAGAATACCCAGAGGGCCCAATACGCCGACCCGCTGTCA           CGAGCGCCCACGAGCGGCAGAACACGACAGGCACACAACCAGCCGGAGCAAGACGGAGCCGAGAGCCC           CGGGGACATAGACCCCAGCAAGCGACACACAAGGACGCGCACAGAGCGCACACACTAACA                                           NOV46j, CG57409-06   SEQ ID NO: 1038   503 aa   MW at 55764.4kD           Protein Sequence                     MSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW           RFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDT       PNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDL       RVPHSYEVRLTPYTTFGAGDMASRIIHYTERQIRWPPVLALRTLSSGPKQGILCRAPHLSSDLVSPLA       FSAINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIE       TSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNPLVRSRNKGALDTHAWSLSGNKGNVW       QQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQTDPNKGARREGGGGAESGGSCAW       RGFLSVEGGCSGLNRGSDCLNMGIRWL                                     NOV46k, CG57409-08   SEQ ID NO: 1039   1369 bp           DNA Sequence   ORF Start: ATG at 17   ORF Stop: end of sequence                       CACCAAGCTTCCCACC   ATG AGCGGGACCTACCGCTGCCAGACGGCCCGCTATAATGGCTTCAACGTGC           GCCCCCGTGAGGCCCAGGTGCAGCTGAACGTGCAGTTCCCGCCGGAGGTGGAGCCCAGTTCCCAGGAC       GTGCGCCAGGCGCTGGGCCGGCCCGTGCTCCTGCGCTGCTCGCTGCTGCGAGGCAGCCCCCAGCGCAT       CGCCTCGGCTGTGTGGCGTTTCAAAGGGCAGCTGCTGCCGCCGCCGCCTGTTGTTCCCGCCGCCGCCG       AGGCGCCGGATCACGCGGAGCTGCGCCTCGACGCCGTAACTCGCGACAGCAGCGGCAGCTACGAGTGC       AGCGTCTCCAACGATGTGGGCTCGGCTGCCTGCCTCTTCCAGGTCTCCGCCAAAGCCTACAGCCCGGA       GTTTTACTTCGACACCCCCAACCCCACCCGCAGCCACAAGCTGTCCAAGAACTACTCCTACGTGCTGC       AGTGGACTCAGAGGGAGCCCGACGCTGTCGACCCTGTGCTCAACTACAGACTCAGCATCCGCCAGTTG       AACCAGCACAATGCGGTGGTCAAGGCCATCCCGGTCCGGCGTGTGGAGAAGGGGCAGCTGCTGGAGTA       CATCCTGACCGATCTCCGTGTGCCCCACAGCTATGAGGTCCGCCTCACACCCTATACCACCTTCGGGG       CTGGTGACATGGCCTCCCGCATCATCCACTACACAGAGCCCATCAACTCTCCGAACCTTTCAGACAAC       ACCTGCCACTTTGAGGATGAGAAGATCTGTGGCTATACCCAGGACCTGACAGACAACTTTGACTGGAC       GCGGCAGAATGCCCTCACCCAGAACCCCAAACGCTCCCCCAACACTGGTCCCCCCACCGACATAAGTG       GCACCCCTGAGGGCTACTACATGTTCATCGAGACATCGAGGCCTCGGGAGCTGGGGGACCGTGCAAGG       TTAGTGAGTCCCCTCTACAATGCCAGCGCCAAGTTCTACTGTGTCTCCTTCTTCTACCACATGTACGG       GAAACACATCGGCTCCCTCAACCTCCTGGTGCGGTCCCGGAACAAAGGGGCTCTGGACACGCACGCCT       GGTCTCTCAGTGGCAATAAGGGCAATGTGTGGCAGCAGGCCCATGTGCCCATCAGCCCCAGTGGGCCC       TTCCAGATTATTTTTGAGGGGGTTCGAGGCCCGGGCTACCTGGGGGATATTGCCATAGATGACGTCAC       ACTGAAGAAGGGGGAGTGTCCCCGGAAGCAGACGGATCCCAATAAAGTGGTGGTGATGCCGGGCAGTG       GAGCCCCCTGCCAGTCCAGCCCACAGCTGTGGGGGCCCATGGCCATCTTCCTCTTGGCGTTGCAGAGA       GAATTCGGC                                         NOV46k, CG57409-08   SEQ ID NO: 1040   451 aa   MW at 50381.4kD           Protein Sequence                     MSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW           RFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDT       PNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDL       RVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNAL       TQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGS       LNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGE       CPRKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQREFG                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 46B.  
               TABLE 46B                       Comparison of the NOV46 protein sequences.                                            NOV46a   ------------------------------------------------------------           NOV46b   ------------------------------------------------------------       NOV46c   ------------------------------------------------------------       NOV46d   ------------------------------------------------------------       NOV46e   ------------------------------------------------------------       NOV46f   MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQC       NOV46g   ------------------------------------------------------------       NOV46h   MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQC       NOV46i   ------------------------------------------------------------       NOV46j   ------------------------------------------------------------       NOV46k   ------------------------------------------------------------               NOV46a   ------------------------------------------------------------       NOV46b   ------------------------------------------------------------       NOV46c   ------------------------------------------------------------       NOV46d   ------------------------------------------------------------       NOV46e   ------------------------------------------------------------       NOV46f   LVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIK       NOV46g   ------------------------------------------------------------       NOV46h   LVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIK       NOV46i   ------------------------------------------------------------       NOV46j   ------------------------------------------------------------       NOV46k   ------------------------------------------------------------               NOV46a   ------------------------------------------------------------       NOV46b   ------------------------------------------------------------       NOV46c   ------------------------------------------------------------       NOV46d   ------------------------------------------------------------       NOV46e   ------------------------------------------------------------       NOV46f   SIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQ       NOV46g   ------------------------------------------------------------       NOV46h   SIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQ       NOV46i   ------------------------------------------------------------       NOV46j   ------------------------------------------------------------       NOV46k   ------------------------------------------------------------               NOV46a   ------------------------------------------------------------       NOV46b   ------------------------------------------------------------       NOV46c   ------------------------------------------------------------       NOV46d   ------------------------------------------------------------       NOV46e   ------------------------------------------------------------       NOV46f   DNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPP       NOV46g   ------------------------------------------------------------       NOV46h   DNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPP       NOV46i   ------------------------------------------------------------       NOV46j   ------------------------------------------------------------       NOV46k   ------------------------------------------------------------               NOV46a   ------------------------------------------------------------       NOV46b   ------------------------------------------------------------       NOV46c   ------------------------------------------------------------       NOV46d   ------------------------------------------------------------       NOV46e   ------------------------------------------------------------       NOV46f   ALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQA       NOV46g   ------------------------------------------------------------       NOV46h   ALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQA       NOV46i   ------------------------------------------------------------       NOV46j   ------------------------------------------------------------       NOV46k   ------------------------------------------------------------               NOV46a   ------------------------------------------------------------       NOV46b   ------------------------------------------------------------       NOV46c   ------------------------------------------------------------       NOV46d   ------------------------------------------------------------       NOV46e   ------------------------------------------------------------       NOV46f   RDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVD       NOV46g   ------------------------------------------------------------       NOV46h   RDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVD       NOV46i   ------------------------------------------------------------       NOV46j   ------------------------------------------------------------       NOV46k   ------------------------------------------------------------               NOV46a   ------------------------------------------------------------       NOV46b   ------------------------------------------------------------       NOV46c   ------------------------------------------------------------       NOV46d   ------------------------------------------------------------       NOV46e   ------------------------------------------------------------       NOV46f   AVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP       NOV46g   ------------------------------------------------------------       NOV46h   AVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFP       NOV46i   ------------------------------------------------------------       NOV46j   ------------------------------------------------------------       NOV46k   ------------------------------------------------------------               NOV46a   ------------------------------------------------------------       NOV46b   ------------------------------------------------------------       NOV46c   ------------------------------------------------------------       NOV46d   ------------------------------------------------------------       NOV46e   ------------------------------------------------------------       NOV46f   GAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDK       NOV46g   ------------------------------------------------------------       NOV46h   GAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDK       NOV46i   ------------------------------------------------------------       NOV46j   ------------------------------------------------------------       NOV46k   ------------------------------------------------------------               NOV46a   ---------------------------MSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE       NOV46b   ------------------------TGTMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE       NOV46c   ---------------------------MSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE       NOV46d   ----------------------TKLPTMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE       NOV46e   -------------------------TKLSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE       NOV46f   EAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE       NOV46g   ------------------------------------------------------------       NOV46h   EAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE       NOV46i   ------------------------------------------------------------       NOV46j   ---------------------------MSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE       NOV46k   ---------------------------MSGTYRCQTARYNGFNVRPREAQVQLNVQFPPE               NOV46a   VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAEL       NOV46b   VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAEL       NOV46c   VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAEL       NOV46d   VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAEL       NOV46e   VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAEL       NOV46f   VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAEL       NOV46g   ------------------------------------------------------------       NOV46h   VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAEL       NOV46i   ------------------------------------------------------------       NOV46j   VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAEL       NOV46k   VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAEL               NOV46a   RLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVL       NOV46b   RLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVL       NOV46c   RLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVL       NOV46d   RLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVL       NOV46e   RLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVL       NOV46f   RLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVL       NOV46g   ------------------------------------------------------------       NOV46h   RLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVL       NOV46i   ------------------------------------------------------------       NOV46j   RLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVL       NOV46k   RLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVL               NOV46a   QWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR       NOV46b   QWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR       NOV46c   QWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR       NOV46d   QWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR       NOV46e   QWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR       NOV46f   QWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR       NOV46g   ----------------------LNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR       NOV46h   QWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR       NOV46i   ----------------------LNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR       NOV46j   QWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR       NOV46k   QWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR               NOV46a   LTPYTTFGAGDMASRIIHYTERQIRWPPVLALRTLSSGPKQGILCRAPHLSSDLVSPLAF       NOV46b   LTPYTTFGAGDMASRIIHYTEP--------------------------------------       NOV46c   LTPYTTFGAGDMASRIIHYTEP--------------------------------------       NOV46d   LTPYTTFGAGDMASRIIHYTEP--------------------------------------       NOV46e   LTPYTTFGAGDMASRIIHYTEP--------------------------------------       NOV46f   LTPYTTFGAGDMASRIIHYTERQIRWPPVLALRTLSSGPKQGILCRAPHLSSDLVSPLAF       NOV46g   LTPYTTFGAGDMASRIIHYTEP---------IN---------------------------       NOV46h   LTPYTTFGAGDMASRIIHYTEP---------IN---------------------------       NOV46i   LTPYTTFGAGDMASRIIHYTEP--------------------------------------       NOV46j   LTPYTTFGAGDMASRIIHYTERQIRWPPVLALRTLSSGPKQGILCRAPHLSSDLVSPLAF       NOV46k   LTPYTTFGAGDMASRIIHYTEP--------------------------------------               NOV46a   SAINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPE       NOV46b   --INSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPE       NOV46c   --INSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPE       NOV46d   --INSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPE       NOV46e   --INSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPE       NOV46f   SAINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPE       NOV46g   ----SPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPE       NOV46h   ----SPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPE       NOV46i   --INSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPE       NOV46j   SAINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPE       NOV46k   --INSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPE               NOV46a   GYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNPLVRSRNKGAL       NOV46b   GYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGAL       NOV46c   GYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGAL       NOV46d   GYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHNYGKHIGSLNLLVRSRNKGAL       NOV46e   GYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGAL       NOV46f   GYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSPNKGAL       NOV46g   GYYMFIETSRPRELGDRARLVSPLYNACAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGAL       NOV46h   GYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGAL       NOV46i   GYYMFIETSRPRELGDRARLVSPLYNACAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGAL       NOV46j   GYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHNYGKHIGSLNPLVRSRNKGAL       NOV46k   GYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHNYGKHIGSLNLLVRSRNKGAL               NOV46a   DTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQ       NOV46b   DTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQ       NOV46c   DTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQ       NOV46d   DTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQ       NOV46e   DTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPREF       NOV46f   DTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQ       NOV46g   DTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPR--       NOV46h   DTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQ       NOV46i   DTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPR--       NOV46j   DTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQ       NOV46k   DTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQ               NOV46a   TDPNKVVVMPGSGAPCQSSPQLWG--------------------PMAIFLLALQR-----       NOV46b   TDPNKVVVMPGSGAPCQSSPQLWG--------------------PMAIFLLALQRLEG--       NOV46c   TDPNKVVVMPGSGAPCQSSPQLWG--------------------PMAIFLLALQR-----       NOV46d   TDPNKVVVMPGSGAPCQSSPQLWG--------------------PMAIFLLALQREFG--       NOV46e   G-----------------------------------------------------------       NOV46f   TDPNKGARREGAACDGLKFHLSSPMDDGELTDDPIECKHLWIHRVDSKGAQYMLAELNCI       NOV46g   ------------------------------------------------------------       NOV46h   TDPNKGARREGAACDGLKFHLSSPMDDGELTDDPIECKHLWIHRVDSKGAQYMLAELNCI       NOV46i   ------------------------------------------------------------       NOV46j   TDPNKGARREGGGGAESGGSCAWRG-----------------FLSVEGGCSGLNRGSDCL       NOV46k   TDPNKVVVMPGSGAPCQSSPQLWG--------------------PMAIFLLALQREFG--               NOV46a   ------------------------------------------------------------       NOV46b   ------------------------------------------------------------       NOV46c   ------------------------------------------------------------       NOV46d   ------------------------------------------------------------       NOV46e   ------------------------------------------------------------       NOV46f   HVAPRFLVFMDEGHKVGEKDSGGQPFQVYTDFSFYPHAIPEKMSIMPTLQVGKLRLREEE       NOV46g   ------------------------------------------------------------       NOV46h   HVAPRFLVFMDEGHKVGEKDSGGQPFQVYTDFSFYPHAIPEKMSIMPTLQVGKLRLREEE       NOV46i   ------------------------------------------------------------       NOV46j   MMGIRWL-----------------------------------------------------       NOV46k   ------------------------------------------------------------               NOV46a   ------------------------------------------------------------       NOV46b   ------------------------------------------------------------       NOV46c   ------------------------------------------------------------       NOV46d   ------------------------------------------------------------       NOV46e   ------------------------------------------------------------       NOV46f   ESAYGHTAAKAPAGTRSWSLNRPPELKSFSLWTNMTQSVREPITGPLQCQTYTHSNTQHL       NOV46g   ------------------------------------------------------------       NOV46h   ESAYGHTAAKARAGTRSWSLNRPPELKSFSLWTNMTQSVREPITGPLQCQTYTHSNTQHL       NOV46i   ------------------------------------------------------------       NOV46j   ------------------------------------------------------------       NOV46k   ------------------------------------------------------------               NOV46a   ------------------------------------------------------------       NOV46b   ------------------------------------------------------------       NOV46c   ------------------------------------------------------------       NOV46d   ------------------------------------------------------------       NOV46e   ------------------------------------------------------------       NOV46f   GTWMKLETIILSKLTQEQKTKHHMFSLTTQSAPPSLFSPELPLSSNSRGHASMSLDDDDD       NOV46g   ------------------------------------------------------------       NOV46h   GTWMKLETIILSKLTQEQKTKHHMFSLTTQSAPPSLFSPELPLSSNSRGHASMSLDDDDD       NOV46i   ------------------------------------------------------------       NOV46j   ------------------------------------------------------------       NOV46k   ------------------------------------------------------------               NOV46a   ------------------------------------------------------------       NOV46b   ------------------------------------------------------------       NOV46c   ------------------------------------------------------------       NOV46d   ------------------------------------------------------------       NOV46e   ------------------------------------------------------------       NOV46f   DDDDDDDDDDDDDNDDDDGRKTYRIPPGSDLSACGWVNDHMSQGDSTGPPDEKHSYAKEE       NOV46g   ------------------------------------------------------------       NOV46h   DDDDDDDDDDDDDNDDDDGRKTYRIPPGSDLSACGWVNDHMSQGDSTGPPDEKHSYAKEE       NOV46i   ------------------------------------------------------------       NOV46j   ------------------------------------------------------------       NOV46k   ------------------------------------------------------------               NOV46a   ------------------------------------------------------------       NOV46b   ------------------------------------------------------------       NOV46c   ------------------------------------------------------------       NOV46d   ------------------------------------------------------------       NOV46e   ------------------------------------------------------------       NOV46f   TQAKLTGPGISYPGKPSYRLHPSGYTPLEQFREKATGMLTPYVSGSVSSFCFPFPTSESL       NOV46g   ------------------------------------------------------------       NOV46h   TQAKLTGPGISYPGKPSYRLHPSGYTPLEQFREKATGMLTPYVSGSVSSFCFPFPTSESL       NOV46i   ------------------------------------------------------------       NOV46j   ------------------------------------------------------------       NOV46k   ------------------------------------------------------------               NOV46a   -----------------------------------       NOV46b   -----------------------------------       NOV46c   -----------------------------------       NOV46d   -----------------------------------       NOV46e   -----------------------------------       NOV46f   CSAHANSPSACLCPL--------------------       NOV46g   -----------------------------------       NOV46h   CSAHANSPSACLCPLLSGLVSPRLCSLGWHALHLP       NOV46i   -----------------------------------       NOV46j   -----------------------------------       NOV46k   -----------------------------------               NOV46a   (SEQ ID NO: 1020)       NOV46b   (SEQ ID NO: 1022)       NOV46c   (SEQ ID NO: 1024)       NOV46d   (SEQ ID NO: 1026)       NOV46e   (SEQ ID NO: 1028)       NOV46f   (SEQ ID NO: 1030)       NOV46g   (SEQ ID NO: 1032)       NOV46h   (SEQ ID NO: 1034)       NOV46i   (SEQ ID NO: 1036)       NOV46j   (SEQ ID NO: 1038)       NOV46k   (SEQ ID NO: 1040)                  
 
      Further analysis of the NOV46a protein yielded the following properties shown in Table 46C.  
               TABLE 46C                       Protein Sequence Properties NOV46a                                        SignalP analysis:   No Known Signal Sequence Predicted                 PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 11; pos. chg 2; neg. chg 0           H-region:   length 6; peak value −8.10           PSG score:   −12.50                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −2.49           possible cleavage site: between 61 and 62                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 0           number of TMS(s) . . . fixed                             PERIPHERAL   Likelihood = 6.21 (at 260)                         ALOM score: 6.21 (number of TMSs: 0}       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   4   Hyd Moment(75):   3.44           Hyd Moment(95):   5.36   G content:   2           D/E content:   1   S/T content:   3                         Score: −1.85                 Gavel: prediction of cleavage sites for mitochondrial preseq                         R-2 motif at 28 VRP|RE                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 10.9%           NLS Score: −0.47                 KDEL: ER retention motif in the C-terminus: none       ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear           discrimination           Prediction: nuclear           Reliability: 76.7       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         47.8%: mitochondrial           47.8%: nuclear            4.3%: cytoplasmic                 &gt;&gt; prediction for CG57409-05 is mit (k = 23)                  
 
      A search of the NOV46a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 46D.  
               TABLE 46D                          Geneseq Results for NOV46a                                             Identities/                   NOV46a   Similarities       Geneseq   Protein/Organism/Length   Residues/   for the   Expect       Identifier   [Patent #, Date]   Match Residues   Matched Region   Value               ABU52337   Human GPCR related protein   1 . . . 488   488/488 (100%)   0.0           NOV13b -  Homo sapiens , 488 aa.   1 . . . 488   488/488 (100%)           [WO200279398-A2, 10-OCT-2002]       ABU52338   Human GPCR related protein   1 . . . 476   461/476 (96%)   0.0           NOV13c -  Homo sapiens , 503 aa.   1 . . . 476   461/476 (96%)           [WO200279398-A2, 10-OCT-2002]       ABJ10922   Human secreted protein (SECP) #18 -   1 . . . 458   457/458 (99%)   0.0             Homo sapiens , 869 aa.   308 . . . 765    457/458 (99%)           [WO200270669-A2, 12-SEP-2002]       ABG12100   Novel human diagnostic protein   1 . . . 458   457/458 (99%)   0.0           #12091 -  Homo sapiens , 1219 aa.   556 . . . 1013    457/458 (99%)           [WO200175067-A2, 11-OCT-2001]       ABU52329   Human GPCR related protein   1 . . . 458   456/458 (99%)   0.0           NOV12a -  Homo sapiens , 1386 aa.   508 . . . 965    456/458 (99%)           [WO200279398-A2, 10-OCT-2002]                  
 
      In a BLAST search of public sequence databases, the NOV46a protein was found to have homology to the proteins shown in the BLASTP data in Table 46E.  
               TABLE 46E                          Public BLASTP Results for NOV46a                                         NOV46a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q8NFP4   Glycosyl-phosphatidyl-inositol-MAM -    1 . . . 488   446/488 (91%)   0.0             Homo sapiens  (Human), 955 aa.   508 . . . 955   446/488 (91%)       Q8HYV1   Glycosylphosphatidylinositol anchor 1    1 . . . 488   430/488 (88%)   0.0           protein -  Sus scrofa  (Pig), 885 aa   438 . . . 885   435/488 (89%)           (fragment).       Q8HYV2   MAM domain containing    1 . . . 488   430/488 (88%)   0.0           glycosylphosphatidylinositol anchor 1 -   439 . . . 886   435/488 (89%)             Sus scrofa  (Pig), 886 aa (fragment).       CAB86653   DJ402N21.2 (novel protein with MAM   176 . . . 488   271/313 (86%)   e−156           domain) -  Homo sapiens  (Human),    1 . . . 273   271/313 (86%)           273 aa (fragment).       Q8NBE3   Hypothetical protein FLJ33358 -   276 . . . 476   185/201 (92%)   e−108             Homo sapiens  (Human), 242 aa.    12 . . . 212   185/201 (92%)                  
 
      PFam analysis predicts that the NOV46a protein contains the domains shown in the Table 46F.  
               TABLE 46F                          Domain Analysis of NOV46a                                             Identities/               Pfam   NOV46a   Similarities for   Expect           Domain   Match Region   the Matched Region   Value                       ig   46 . . . 110   17/66 (26%)   0.0094                   38/66 (58%)           MAM   286 . . . 451    78/185 (42%)    6.1e−74                   146/185 (79%)                       
 
     Example 47 
     
       
         
           
               
             
               
                 TABLE 47A 
               
               
                   
               
               
                   
               
               
                 NOV47 Sequence Analysis 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 NOV47a, CG57448-01 
                 SEQ ID NO: 1041 
                 2907 bp 
                   
               
               
                 DNA Sequence 
                 ORF Start: ATG at 10 
                 ORF Stop: TGA at 2896 
               
            
           
           
               
               
            
               
                   GGCCGCTGA   ATG CTAGCTAGAATTCAGCGGCCGCTGAATTCTAGGCGCTGCCGAGGGAATGCGCGCAG 
                   
               
               
                 CTCACAGGCCCTGGGAGTGAGCTGGTGCCCGGCGACCTGGCACCCGCGCCTGGATATGGGGCGTCTAC 
               
               
                 ATCGTCCCAGGAGCAGCACCAGCTACAGGAACCTGCCGCATCTGTTTCTGTTTTTCCTCTTCGTGGGA 
               
               
                 CCCTTCAGCTGCCTCGGGAGTTACAGCCGGGCCACCGAGCTTCTGTACAGCCTAAACGAGGGACTACC 
               
               
                 CGCGGGGGTGCTCATCGGCAGCCTGGCCGAGGACCTGCGGCTGCTGCCCAGGTCTGCAGGGAGGCCGG 
               
               
                 ACCCGCAGTCGCAGCTGCCAGAGCGCACCGGTGCTGAGTGGAACCCCCCTCTCTCCTTCAGCCTGGCC 
               
               
                 TCCCGGGGACTGAGTGGCCAGTACGTGACCCTAGACAACCGCTCTGGGGAGCTGCACACTTCAGCTCA 
               
               
                 GGAGATCGACAGGGAGGCCCTGTGTGTTGAAGGGGGTGGAGGGACTGCGTGGAGCGGCAGCGTTTCCA 
               
               
                 TCTCCTCCTCTCCTTCTGACTCTTGTCTTTTGCTGCTGGATGTGCTTGTCCTGCCTCAGGAATACTTC 
               
               
                 AGGTTTGTGAAGGTGAAGATCGCCATCAGAGACATCAATGACAACGCCCCGCAGTTCCCTGTTTCCCA 
               
               
                 GATCTCGGTGTGGGTCCCGGAAAATGCACCTGTAAACACCCGACTGGCCATAGAGCATCCTGCTGTGG 
               
               
                 ACCCAGATGTAGGCATTAATGGGGTACAGACCTATCGCTTACTGGACTACCATGGTATGTTCACCCTG 
               
               
                 GACGTGGAGGAGAATGAGAATGGGGAGCGCACCCCCTACCTAATTGTCATGGGTGCTTTGGACAGGGA 
               
               
                 AACCCAGGACCAGTATGTGAGCATCATCATAGCTGAGGATGGTGGGTCTCCACCACTTTTGGGCAGTG 
               
               
                 CCACTCTCACCATTGGCATCAGTGACATTAATGACAATTGCCCTCTCTTCACAGACTCACAAATCAAT 
               
               
                 GTCACTGTGTATGGGAATGCTACAGTGGGCACCCCAATTGCAGCTGTCCAGGCTGTGGATAAAGACTT 
               
               
                 GGGGACCAATGCTCAAATTACTTATTCTTACAGTCAGAAAGTTCCACAAGCATCTAAGGATTTATTTC 
               
               
                 ACCTGGATGAAAACACTGGAGTCATTAAACTTTTCAGTAAGATTGGAGGAAGTGTTCTGGAGTCCCAC 
               
               
                 AAGCTCACCATCCTTGCTAATGGACCAGGCTGCATCCCTGCTGTAATCACTGCTCTTGTGTCCATTAT 
               
               
                 TAAAGTTATTTTCAGACCCCCTGAAATTGTCCCTCGTTACATAGCAAACGAGATAGATGGTGTTGTTT 
               
               
                 ATCTGAAAGAACTGGAACCCGTTAACACTCCCATTGCGTTTTTCACCATAAGAGATCCAGAAGGTAAA 
               
               
                 TACAAGGTTAACTGCTACCTGGATGGTGAAGGGCCGTTTAGGTTATCACCTTACAAACCATACAATAA 
               
               
                 TGAATATTTACTAGAGACCACAAAACCTATGGACTATGAGCTACAGCAGTTCTATGAAGTAGCTGTGG 
               
               
                 TGGCTTGGAACTCTGAGGGATTTCATGTCAAAAGGGTCATTAAAGTGCAACTTTTAGATGACAATGAT 
               
               
                 AATGCTCCAATTTTCCTTCAACCCTTAATAGAACTAACCATCGAAGAGAACAACTCACCCAATGCCTT 
               
               
                 TTTGACTAAGCTGTATGCTACAGATGCCGACAGCGAGGAGAGAGGCCAAGTTTCATATTTTCTGGGAC 
               
               
                 CTGATGCTCCATCATATTTTTCCTTAGACAGTGTCACAGGAATTCTGACAGTTTCTACTCAGCTGGAC 
               
               
                 CGAGAAGAGAAAGAAAAGTACAGATACACTGTCAGAGCTGTTGACTGTGGGAAGCCACCCAGAGAATC 
               
               
                 AGTAGCCACTGTGGCCCTCACAGTGTTGGATAAAAATGACAACAGTCCTCGGTTTATCAACAAGGACT 
               
               
                 TCAGCTTTTTTGTGCCTGAAAACTTTCCAGGCTATGGTGAGATTGGAGTAATTAGTGTAACAGATGCT 
               
               
                 GACGCTGGACGAAATGGATGGGTCGCCCTCTCTGTGGTGAACCAGAGTGATATTTTTGTCATAGATAC 
               
               
                 AGGAAAGGGTATGCTGAGGGCTAAAGTCTCTTTGGACAGAGAGCAGCAAAGCTCCTATACTTTGTGGG 
               
               
                 TTGAAGCTGTTGATGGGGGTGAGCCTGCCCTCTCCTCTACAGCAAAAATCACAATTCTCCTTCTAGAT 
               
               
                 ATCAATGACAACCCTCCTCTTGTTTTGTTTCCTCAGTCTAATATGTCTTATCTGTTAGTACTGCCTTC 
               
               
                 TACTCTGCCAGGCTCCCCGGTTACAGAAGTCTATGCTGTCGACAAAGACACAGGCATGAATGCTGTCA 
               
               
                 TAGCTTACAGCATCATAGGGAGAAGAGGTCCTAGGCCTGAGTCCTTCAGGATTGACCCTAAAACTGGC 
               
               
                 AACATTACTTTGGAAGAGGCATTGCTGCAGACAGATTATGGGCTCCATCGCTTACTGGTGAAAGTGAG 
               
               
                 TGATCATGGTTATCCCGAGCCTCTCCACTCCACAGTCATGGTGAACCTATTTGTCAATGACACTGTCA 
               
               
                 GTAATGAGAGTTACATTGAGAGTCTTTTAAGAAAAGAACCAGAGATTAATATAGAGGAGAAAGAACCA 
               
               
                 CAAATCTCAATAGAACCGACTCATAGGAAGGTAGAATCTGTGTCTTGTATGCCCACCTTAGTAGCTCT 
               
               
                 GTCTGTAATAAGCTTGGGTTCCATCACACTGGTCACAGGGATGGGCATATACATCTGTTTAAGGAAAG 
               
               
                 GGGAAAAGCATCCCAGGGAAGATGAAAATTTGGAAGTACAGATTCCACTGAAAGGAAAAATTGACTTG 
               
               
                 CATATGCGAGAGAGAAAGCCAATGGATATTTCTAATATT TGA   TATTTCATG   
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 NOV47a, CG57448-01 
                 SEQ ID NO: 1042 
                 962 aa 
                 MW at 106269.4kD 
                   
               
               
                 Protein Sequence 
               
            
           
           
               
               
            
               
                 MLARIQRPLNSRRCRGNARSSQALGVSWCPATWHPRLDMGRLHRPRSSTSYRNLPHLFLFFLFVGPFS 
                   
               
               
                 CLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRG 
               
               
                 LSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEYFRFV 
               
               
                 KVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVE 
               
               
                 ENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTV 
               
               
                 YGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLT 
               
               
                 ILANGPGCIPAVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKV 
               
               
                 NCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAP 
               
               
                 IFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDREE 
               
               
                 KEKYRYTVPAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAG 
               
               
                 RNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDIND 
               
               
                 NPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNIT 
               
               
                 LEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQIS 
               
               
                 IEPTHRKVESVSCMPTLVALSVISLGSITLVTGMGIYICLRKGEKHPREDENLEVQIPLKGKIDLHMR 
               
               
                 ERKPMDISNI 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 NOV47b, 247846705 
                 SEQ ID NO: 1043 
                 1377 bp 
                   
               
               
                 DNA Sequence 
                 ORF Start: at 1 
                 ORF Stop: end of sequence 
               
            
           
           
               
               
            
               
                 GGATCCCCTCGTTACATAGCAAACGAGATAGATGGTGTTGTTTATCTGAAAGAACTGGAACCCGTTAA 
                   
               
               
                 CACTCCCATTGCGTTTTTCACCATAAGAGATCCAGAAGGTAAATACAAGGTTAACTGCTACCTGGATG 
               
               
                 GTGAAGGGCCGTTTAGGTTATCACCTTACAAACCATACAATAATGAATATTTACTAGAGACCACAAAA 
               
               
                 CCTATGGACTATGAGCTACAGCAGTTCTATGAAGTAGCTGTGGTGGCTTGGAACTCTGAGGGATTTCA 
               
               
                 TGTCAAAAGGGTCATTAAAGTGCAACTTTTAGATGACAATGATAATGCTCCAATTTTCCTTCAACCCT 
               
               
                 TAATAGACTAACCATCGAAGAGAACAACTCACCCAATGCCTTTTTGACTAAGGTGTATGCTACAGAT 
               
               
                 GCCGACAGCGAGGAGAGAGGCCAAGTTTCATATTTTCTGGGACCTGATGCTCCATCATATTTTTCCTT 
               
               
                 AGACAGTGTCACAGGAATTCTGACAGTTTCTACTCAGCTGGACCGAGAAGAGAAAGAAAAGTACAGAT 
               
               
                 ACACTGTCAGAGCTGTTGACTGTGGGAAGCCACCCAGAGAATCAGTAGCCACTGTGGCCCTCACAGTG 
               
               
                 TTGGATAAAAATGACAACAGTCCTCGGTTTATCAACAAGGACTTCAGCTTTTTTGTGCCTGAAAACTT 
               
               
                 TCCAGGCTATGGTGAGATTGGAGTAATTAGTGTAACAGATGCTGACGCTGGACGAAATGGATGGGTCG 
               
               
                 CCCTCTCTGTGGTGAACCAGAGTGATATTTTTGTCATAGATACAGGAAAGGGTATGCTGAGGGCTAAA 
               
               
                 GTCTCTTTGGACAGAGAGCAGCAAAGCTCCTATACTTTGTGGGTTGAAGCTGTTGATGGGGGTGAGCC 
               
               
                 TGCCCTCTCCTCTACAGCAAAAATCACAATTCTCCTTCTAGATATCAATGACAACCCTCCTCTTGTTT 
               
               
                 TGTTTCCTCAGTCTAATATGTCTTATCTGTTAGTACTGCCTTCTACTCTGCCAGGCTCCCCGGTTACA 
               
               
                 GAAGTCTATGCTGTCGACAAAGACACAGGCATGAATGCTGTCATAGCTTACAGCATCATAGGGAGAAG 
               
               
                 AGGTCCTAGGCCTGAGTCCTTCAGGATTGACCCTAAAACTGGCAACATTACTTTGGAAGAGGCATTGC 
               
               
                 TGCAGACAGATTATGGGCTCCATCGCTTACTGGTGAAAGTGAGTGATCATGGTTATCCCGAGCCTCTC 
               
               
                 CACTCCACAGTCATGGTGAACCTATTTGTCAATGACACTGTCAGTAATGAGAGTTACATTGAGAGTCT 
               
               
                 TTTAAGAAAAGAACCAGAGATTAATATAGAGGAGAAAGAACCACAAATCTCAATAGAACCGACTCATA 
               
               
                 GGAAGGTAGAACTCGAG 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 NOV47b, 247846705 
                 SEQ ID NO: 1044 
                 459 aa 
                 MW at 51423.4kD 
                   
               
               
                 Protein Sequence 
               
            
           
           
               
               
            
               
                 GSPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEYLLETTK 
                   
               
               
                 PMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKVYATD 
               
               
                 ADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVPAVDCGKPPRESVATVALTV 
               
               
                 LDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAK 
               
               
                 VSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVT 
               
               
                 EVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPL 
               
               
                 HSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVELE 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 NOV47c, 247846708 
                 SEQ ID NO: 1045 
                 1377 bp 
                   
               
               
                 DNA Sequence 
                 ORF Start: at 1 
                 ORF Stop: end of sequence 
               
            
           
           
               
               
            
               
                 GGATCCCCTCGTTACATAGCAAACGAGATAGATGGTGTGGTTTATCTGAAAGAACTGGAACCCGTTAA 
                   
               
               
                 CACTCCCATTGCGTTTTTCACCATAAGAGATCCAGAAGGTAAATACAAGGTTAACTGCTACCTGGATG 
               
               
                 GTGAAGGGCCGTTTAGGTTATCACCTTACAAACCATACAATAATGAATATTTACTAGAGACCACAAAA 
               
               
                 CCTATGGACTATGAGCTACAGCAGTTCTATGAAGTAGCTGTGGTGGCTTGGAACTCTGAGGGATTTCA 
               
               
                 TGTCAAAAGGGTCATTAAAGTGCAACTTTTAGATGACAATGATAATGCTCCAATTTTCCTTCAACCCT 
               
               
                 TAATAGAACTAACCATCGAAGAGAACAACTCACCCAATGCCTTTTTGACTAAGCTGTATGCTACAGAT 
               
               
                 GCCGACAGCGAGGAGAGAGGCCAAGTTTCATATTTTCTGGGACCTGATGCTCCATCATATTTTTCCTT 
               
               
                 AGACAGTGTCACAGGAATTCTGACAGTTTCTACTCAGCTGGACCGAGAAGAGAAAGAAAAGTACAGAT 
               
               
                 ACACTGTCAGAGCTGTTGACTGTGGGAAGCCACCCAGAGAATCAGTAGCCACTGTGGCCCTCACAGTG 
               
               
                 TTGGATAAAAATGACAACAGTCCTCGGTTTATCAACAAGGACTTCAGCTTTTTTGTGCCTGAAAACTT 
               
               
                 TCCAGGCTATGGTGAGATTGGAGTAATTAGTGTAACAGATGCTGACGCTGGACGAAATGGATGGGTCG 
               
               
                 CCCTCTCTGTGGTGAACCAGAGTGATATTTTTGTCATAGATACAGGAAAGGGTATGCTGAGGGCTAAA 
               
               
                 GTCTCTTTGGACAGAGAGCAGCAAAGCTCCTATACTTTGTGGGTTGAAGCTGTTGATGGGGGTGAGCC 
               
               
                 TGCCCTCTCCTCTACAGCAAAAATCACAATTCTCCTTCTAGATATCAATGACAACCCTCCTCTTGTTT 
               
               
                 TGTTTCCTCAGTCTAATATGTCTTATCTGTTAGTACTGCCTTCTACTCTGCTAGGCTCCCCGGTTACA 
               
               
                 GAAGTCTATGCTGTCGACAAAGACACAGGCATGAATGCTGTCATAGCTTACAGCATCATAGGGAGAAG 
               
               
                 AGGTCCTAGGCCTGAGTCCTTCAGGATTGACCCTAAAACTGGCAACATTACTTTGGAAGAGGCATTGC 
               
               
                 TGCAGACAGATTATGGGCTCCATCGCTTACTGGTGAAAGTGAGTGATCATGGTTATCCCGAGCCTCTC 
               
               
                 CACTCCACAGTCATGGTGAACCTATTTGTCAATGACACTGTCAGTAATGAGAGTTACATTGAGAGTCT 
               
               
                 TTTAAGAAAAGAACCAGAGATTAATATAGAGGAGAAAGAACCACAAATCTCAATAGAACCGACTCATA 
               
               
                 GGAAGGTAGAACTCGAG 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 NOV47c, 247846708 
                 SEQ ID NO: 1046 
                 459 aa 
                 MW at 51453.4kD 
                   
               
               
                 Protein Sequence 
               
            
           
           
               
               
            
               
                 GSPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEYLLETTK 
                   
               
               
                 PMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATD 
               
               
                 ADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVPAVDCGKPPRESVATVALTV 
               
               
                 LDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAK 
               
               
                 VSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLLGSPVT 
               
               
                 EVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPL 
               
               
                 HSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVELE 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 NOV47d, 237580295 
                 SEQ ID NO: 1047 
                 1377 bp 
                   
               
               
                 DNA Sequence 
                 ORF Start: at 1 
                 ORF Stop: end of sequence 
               
            
           
           
               
               
            
               
                 GGATCCCCTCGTTACATAGCAAACGAGATAGATGGTGTTGTTTATCTGAAAGAACTGGAACCCGTTAA 
                   
               
               
                 CACTCCCATTGCGCTTTTCACCATAAGAGATCCAGAAGGTAAATACAAGGTTAACTGCTACCTGGATG 
               
               
                 GTGAAGGGCCGTTTAGGTTATCACCTTACAAACCATACAATAATGAATATTTACTAGAGACCACAAAA 
               
               
                 CCTATGGACTATGAGCTACAGCAGTTCTATGAAGTAGCTGTGGTGGCTTGGAACTCTGAGGGATTTCA 
               
               
                 TGTCAAAAGGGTCATTAAAGTGCAACTTTTAGATGACAATGATAATGCTCCAATTTTCCTTCAACCCT 
               
               
                 TAATAGAACTAACCATCGAAGAGAACAACTCACCCAATGCCTTTTTGACTAAGCTGTATGCTACAGAT 
               
               
                 GCCGACAGCGAGGAGAGAGGCCAAGTTTCATATTTTCTGGGACCTGATGCTCCATCATATTTTTCCTT 
               
               
                 AGACAGTGTCACAGGAATTCTGACAGTTTCTACTCAGCTGGACCGAGAAGAGAAAGAAAAGTACAGAT 
               
               
                 ACACTGTCAGAGCTGTTGACTGTGGGAAGCCACCCAGAGAATCAGTAGCCACTGTGGCCCTCACAGTG 
               
               
                 TTGGATAAAAATGACAACAGTCCTCGGTTTATCAACAAGGACTTCAGCTTTTTTGTGCCTGAAAACTT 
               
               
                 TCCAGGCTATGGTGAGATTGGAGTAATTAGTGTAACAGATGCTGACGCTGGACGAAATGGATGGGTCG 
               
               
                 CCCTCTCTGTGGTGAACCAGAGTGATATTTTTGTCATAGATACAGGAAAGGGTATGCTGAGGGCTAAA 
               
               
                 GTCTCTTTGGACAGAGAGCAGCAAAGCTCCTATACTTTGTGGGTTGAAGCTGTTGATGGGGGTGAGCC 
               
               
                 TGCCCTCTCCTCTACAGCAAAAATCACAATTCTCCTTCTAGATATCAATGACAACCCTCCTCTTGTTT 
               
               
                 TGTTTCCTCAGTCTAATATGTCTTATCTGTTAGTACTGCCTTCTACTCTGCCAGGCTCCCCGGTTACA 
               
               
                 GAAGTCTATGCTGTCGACAAAGACACAGGCATGAATGCTGTCATAGCTTACAGCATCATAGGGAGAAG 
               
               
                 AGGTCCTAGGCCTGAGTCCTTCAGGATTGACCCTAAAACTGGCAACATTACTTTGGAAGAGGCATTGC 
               
               
                 TGCAGACAGATTATGGGCTCCATCGCTTACTGGTGAAAGTGAGTGATCATGGTTATCCCGAGCCTCTC 
               
               
                 CACTCCACAGTCATGGTGAACCTATTTGTCAATGACACTGTCAGTAATGAGAGTTACATTGAGAGTCT 
               
               
                 TTTAAGAAAAGAACCAGAGATTAATATAGAGGAGAAAGAACCACAAATCTCAATAGAACCGACTCATA 
               
               
                 GGAAGGTAGAACTCGAG 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 NOV47d, 237580295 
                 SEQ ID NO: 1048 
                 459 aa 
                 MW at 51403.4kD 
                   
               
               
                 Protein Sequence 
               
            
           
           
               
               
            
               
                 GSPRYIANEIDGVVYLKELEPVNTPIALFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEYLLETTK 
                   
               
               
                 PMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATD 
               
               
                 ADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTV 
               
               
                 LDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAK 
               
               
                 VSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVT 
               
               
                 EVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPL 
               
               
                 HSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVELE 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 NOV47e, 237579512 
                 SEQ ID NO: 1049 
                 1377 bp 
                   
               
               
                 DNA Sequence 
                 ORF Start: at 1 
                 ORF Stop: end of sequence 
               
            
           
           
               
               
            
               
                 GGATCCCCTCGTTACATAGCAAACGAGATAGATGGTGTGGTTTATCTGAAAGAACTGGAACCCGTTAA 
                   
               
               
                 CACTCCCATTGCGTTTTTCACCATAAGAGATCCAGAAGGTAAATACAAGGTTAACTGCTACCTGGATG 
               
               
                 GTGAAGGGCCGTTTAGGTTATCACCTTACAAACCATACAATAATGAATATTTACTAGAGACCACAAAA 
               
               
                 CCTATGGACTATGAGCTACAGCAGTTCTATGAAGTAGCTGTGGTGGCTTGGAACTCTGAGGGATTTCA 
               
               
                 TGTCAAAAGGGTCATTAAAGTGCAACTTTTAGATGACAATGATAATGCTCCAATTTTCCTTCAACCCT 
               
               
                 TAATAGAACTAACCATCGAAGAGAACAACTCACCCAATGCCTTTTTGACTAAGCTGTATGCTACAGAT 
               
               
                 GCCGACAGCGAGGAGAGAGGCCAAGTTTCATATTTTCTGGGACCTGATGCTCCATCATATTTTTCCTT 
               
               
                 AGACAGTGTCACAGGAATTCTGACAGTTTCTACTCAGCTGGACCGAGAAGAGAAAGAAAAGTACAGAT 
               
               
                 ACACTGTCAGAGCTGTTGACTGTGGGAAGCCACCCAGAGAATCAGTAGCCACTGTGGCCCTCACAGTG 
               
               
                 TTGGATAAAAATGACAACAGTCCTCGGTTTATCAACAAGGACTTCAGCTTTTTTGTGCCTGAAAACTT 
               
               
                 TCCAGGCTATGGTGAGATTGGAGTAATTAGTGTAACAGATGCTGACGCTGGACGAAATGGATGGGTCG 
               
               
                 CCCTCTCTGTGGTGAACCAGAGTGATATTTTTGTCATAGATACAGGAAAGGGTATGCTGAGGGCTAAA 
               
               
                 GTCTCTTTGGACAGAGAGCAGCA)AGCTCCTATACTTTGTGGGTTGAAGCTGTTGATGGGGGTGAGCC 
               
               
                 TGCCCTCTCCTCTACAGCAAAAATCACAATTCTCCTTCTAGATATCAATGACAACCCTCCTCTTGTTT 
               
               
                 TGTTTCCTCAGTCTAATATGTCTTATCTGTTAGTACTGCCTTCTACTCTGCCAGGCTCCCCGGTTACA 
               
               
                 GAAGTCTATGCTGTCGACAAAGACACAGGCATGAATGCTGTCATAGCTTACAGCATCATAGGGAGAAG 
               
               
                 AGGTCCTAGGCCTGAGTCCTTCAGGATTGACCCTAAAACTGGCAACATTACTTTGGAAGAGGCATTGC 
               
               
                 TGCAGACAGATTATGGGCTCCATCGCTTACTGGTGAAAGTGAGTGATCATGGTTATCCCGAGCCTCTC 
               
               
                 CACTCCACAGTCATGGTGAACCTATTTGTCAATGACACTGTCAGTAATGAGAGTTACATTGAGAGTCT 
               
               
                 TTTAAGAAAAGAACCAGAGATTAATATAGAGGAGAAAGAACCACAAATCTCAATAGAACCGACTCATA 
               
               
                 GGAAGGTAGAACTCGAG 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 NOV47e, 237579512 
                 SEQ ID NO: 1050 
                 459 aa 
                 MW at 51437.4kD 
                   
               
               
                 Protein Sequence 
               
            
           
           
               
               
            
               
                 GSPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEYLLETTK 
                   
               
               
                 PMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATD 
               
               
                 ADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVEAVDCGKPPRESVATVALTV 
               
               
                 LDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAK 
               
               
                 VSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVT 
               
               
                 EVYAVDKDTGHNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPL 
               
               
                 HSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVELE 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 NOV47f, CG57448-02 
                 SEQ ID NO: 1051 
                 576 bp 
                   
               
               
                 DNA Sequence 
                 ORF Start: at 7 
                 ORF Stop: at 571 
               
            
           
           
               
               
            
               
                   GGATCC ATCTCGGTGTGGGTCCCGGAAAATGCACCTGTAAACACCCGACTGGCCATAGAGCATCCTGC 
                   
               
               
                 TGTGGACCCAGATGTAGGCATTAATGGGGTACAGACCTATCGCTTACTGGACTACCATGGTATGTTCA 
               
               
                 CCCTGGACGTGGAGGAGAATGAGAATGGGGAGCGCACCCCCTACCTAATTGTCATGGGTGCTTTGGAC 
               
               
                 AGGGAAACCCAGGACCAGTATGTGAGCATCATCATAGCTGAGGATGGTGGGTCTCCACCACTTTTGGG 
               
               
                 CAGTGCCACTCTCACCATTGGCATCAGTGACATTAATGACAATTGCCCTCTCTTCACAGACTCACAAA 
               
               
                 TCAATGTCACTGTGTATGGGAATGCTACAGTGGGCACCCCAATTGCAGCTGTCCAGGCTGTGGATAAA 
               
               
                 GACTTGGGGACCAATGCTCAAATTACTTATTCTTACAGTCAGAAAGTTCCACAAGCATCTAAGGATTT 
               
               
                 ATTTCACCTGGATGAAAACACTGGAGTCATTAAACTTTTCAGTAAGATTGGAGGAAGTGTTCTGGAGT 
               
               
                 CCCACAAGCTCACCATCCTTGCTAATCTC GAG   
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 NOV47f, CG57448-02 
                 SEQ ID NO: 1052 
                 188 aa 
                 MW at 20271.5kD 
                   
               
               
                 Protein Sequence 
               
            
           
           
               
               
            
               
                 ISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRE 
                   
               
               
                 TQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDL 
               
               
                 GTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILAN 
               
               
                   
               
            
           
         
       
     
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 47B.  
               TABLE 47B                       Comparison of the NOV47 protein sequences.                                            NOV47a   MLARIQRPLNSRRCRGNARSSQALGVSWCPATWHPRLDMGRLHRPRSSTSYRNLPHLFLF           NOV47b   ------------------------------------------------------------       NOV47c   ------------------------------------------------------------       NOV47d   ------------------------------------------------------------       NOV47e   ------------------------------------------------------------       NOV47f   ------------------------------------------------------------               NOV47a   FLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERT       NOV47b   ------------------------------------------------------------       NOV47c   ------------------------------------------------------------       NOV47d   ------------------------------------------------------------       NOV47e   ------------------------------------------------------------       NOV47f   ------------------------------------------------------------               NOV47a   GAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSIS       NOV47b   ------------------------------------------------------------       NOV47c   ------------------------------------------------------------       NOV47d   ------------------------------------------------------------       NOV47e   ------------------------------------------------------------       NOV47f   ------------------------------------------------------------               NOV47a   SSPSDSCLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLA       NOV47b   ------------------------------------------------------------       NOV47c   ------------------------------------------------------------       NOV47d   ------------------------------------------------------------       NOV47e   ------------------------------------------------------------       NOV47f   ------------------------------------------------------------               NOV47a   IEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSI       NOV47b   ------------------------------------------------------------       NOV47c   ------------------------------------------------------------       NOV47d   ------------------------------------------------------------       NOV47e   ------------------------------------------------------------       NOV47f   ------------------------------------------------------------               NOV47a   IIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDL       NOV47b   ------------------------------------------------------------       NOV47c   ------------------------------------------------------------       NOV47d   ------------------------------------------------------------       NOV47e   ------------------------------------------------------------       NOV47f   ------------------------------------------------------------               NOV47a   GTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAV       NOV47b   ------------------------------------------------------------       NOV47c   ------------------------------------------------------------       NOV47d   ------------------------------------------------------------       NOV47e   ------------------------------------------------------------       NOV47f   ------------------------------------------------------------               NOV47a   ITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYL       NOV47b   ----------------GSPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYL       NOV47c   ----------------GSPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYL       NOV47d   ----------------GSPRYIANEIDGVVYLKELEPVNTPIALFTIRDPEGKYKVNCYL       NOV47e   ----------------GSPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYL       NOV47f   ------------------------------------------------------------               NOV47a   DGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDN       NOV47b   DGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDN       NOV47c   DGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDN       NOV47d   DGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDN       NOV47e   DGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDN       NOV47f   ------------------------------------------------------------               NOV47a   DNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTG       NOV47b   DNAPIFLQPLIELTIEENNSPNAFLTKVYATDADSEERGQVSYFLGPDAPSYFSLDSVTG       NOV47c   DNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTG       NOV47d   DNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTG       NOV47e   DNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTG       NOV47f   ------------------------------------------------------------               NOV47a   ILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVP       NOV47b   ILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVP       NOV47c   ILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVP       NOV47d   ILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVP       NOV47e   ILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVP       NOV47f   ------------------------------------------------------ISVWVP               NOV47a   ENFPGYGEIGVIS-VTDADAGRNGWVALSVVNQSDIFVIDTGKG-------MLRAKVSLD       NOV47b   ENFPGYGEIGVIS-VTDADAGRNGWVALSVVNQSDIFVIDTGKG-------MLRAKVSLD       NOV47c   ENFPGYGEIGVIS-VTDADAGRNGWVALSVVNQSDIFVIDTGKG-------MLRAKVSLD       NOV47d   ENFPGYGEIGVIS-VTDADAGRNGWVALSVVNQSDIFVIDTGKG-------MLRAKVSLD       NOV47e   ENFPGYGEIGVIS-VTDADAGRNGWVALSVVNQSDIFVIDTGKG-------MLRAKVSLD       NOV47f   ENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALD               NOV47a   REQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPG       NOV47b   REQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPG       NOV47c   REQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLLG       NOV47d   REQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPG       NOV47e   REQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPG       NOV47f   RETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQ--IN-VTVYGNATVG               NOV47a   SPVTEVYAVDKDTGMNAVIAYSIIGRR-GPRPESFRIDPKTGNITLEEALLQTDYGLHRL       NOV47b   SPVTEVYAVDKDTGMNAVIAYSIIGRR-GPRPESFRIDPKTGNITLEEALLQTDYGLHRL       NOV47c   SPVTEVYAVDKDTGMNAVIAYSIIGRR-GPRPESFRIDPKTGNITLEEALLQTDYGLHRL       NOV47d   SPVTEVYAVDKDTGMNAVIAYSIIGRR-GPRPESFRIDPKTGNITLEEALLQTDYGLHRL       NOV47e   SPVTEVYAVDKDTGMNAVIAYSIIGRR-GPRPESFRIDPKTGNITLEEALLQTDYGLHRL       NOV47f   TPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKL               NOV47a   LVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRK       NOV47b   LVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRK       NOV47c   LVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRK       NOV47d   LVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRK       NOV47e   LVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRK       NOV47f   TILAN-------------------------------------------------------               NOV47a   VESVSCMPTLVALSVISLGSITLVTGMGIYICLRKGEKHPREDENLEVQIPLKGKIDLHM       NOV47b   VELE--------------------------------------------------------       NOV47c   VELE--------------------------------------------------------       NOV47d   VELE--------------------------------------------------------       NOV47e   VELE--------------------------------------------------------       NOV47f   ------------------------------------------------------------               NOV47a   RERKPMDISNI       NOV47b   -----------       NOV47c   -----------       NOV47d   -----------       NOV47e   -----------       NOV47f   -----------               NOV47a   (SEQ ID NO: 1042)       NOV47b   (SEQ ID NO: 1044)       NOV47c   (SEQ ID NO: 1046)       NOV47d   (SEQ ID NO: 1048)       NOV47e   (SEQ ID NO: 1050)       NOV47f   (SEQ ID NO: 1052)                  
 
      Further analysis of the NOV47a protein yielded the following properties shown in Table 47C.  
               TABLE 47C                       Protein Sequence Properties NOV47a                                        SignalP analysis:   Cleavage site between residues 14 and 15       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 7; pos. chg 2; neg. chg 0           H-region:   length 4; peak value −19.10           PSG score:   −23.50                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −9.89           possible cleavage site: between 29 and 30                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 3                                 INTEGRAL   Likelihood =   Transmembrane  54-70               −2.76           INTEGRAL   Likelihood =   Transmembrane 416-432               −7.38           INTEGRAL   Likelihood =   Transmembrane 901-917               −3.77                             PERIPHERAL   Likelihood = 2.01 (at 188)                         ALOM score: −7.38 (number of TMSs: 3)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 61           Charge difference: −5.0 C(−1.0)-N(4.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 3a       MITDISC: discrimination of mitochondrial targeting seq                                     R content:    7   Hyd Moment(75):   5.23           Hyd Moment(95):   11.82   G content:   2           D/E content:    1   S/T content:   5                         Score: 2.50                 Gavel: prediction of cleavage sites for mitochondrial preseq                         R-2 motif at 85 SRA|TE                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 8.9%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: LARI       none                 SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none       NMYR:   N-myristoylation pattern: none                 Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 76.7       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         34.8%: mitochondrial           34.8%: endoplasmic reticulum           17.4%: nuclear            4.3%: cytoplasmic            4.3%: plasma membrane            4.3%: vesicles of secretory system                 &gt;&gt; prediction for CG57448-01 is mit (k = 23)                  
 
      A search of the NOV47a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 47D.  
               TABLE 47D                          Geneseq Results for NOV47a                                         NOV47a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               ABU52605   Human NOVX protein, NOV16a -   1 . . . 962    962/962 (100%)   0.0             Homo sapiens , 962 aa.   1 . . . 962    962/962 (100%)           [WO200281518-A2, 17-OCT-2002]       ABP70119   Human NOV32a -  Homo sapiens , 947   16 . . . 962    946/947 (99%)   0.0           aa. [WO200272771-A2, 19-SEP-2002]   1 . . . 947   946/947 (99%)       AAU09958   Human cadherin-1 (CDHN-1) protein -   39 . . . 962     924/924 (100%)   0.0             Homo sapiens , 924 aa.   1 . . . 924    924/924 (100%)           [WO200179293-A2, 25-OCT-2001]       ABP47865   Human polypeptide SEQ ID NO 295 -   566 . . . 962    396/397 (99%)   0.0             Homo sapiens , 397 aa.   1 . . . 397   397/397 (99%)           [US2002042386-A1, 11-APR-2002]       AAU19645   Human novel extracellular matrix   566 . . . 962    396/397 (99%)   0.0           protein, Seq ID No 295 -  Homo     1 . . . 397   397/397 (99%)             sapiens , 397 aa. [WO200155368-A1,           02-AUG-2001]                  
 
      In a BLAST search of public sequence databases, the NOV47a protein was found to have homology to the proteins shown in the BLASTP data in Table 47E.  
               TABLE 47E                          Public BLASTP Results for NOV47a                                         NOV47a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q8NDN4   Hypothetical protein -  Homo     13 . . . 962   949/950 (99%)   0.0             sapiens  (Human), 951 aa.    2 . . . 951   949/950 (99%)       Q9NRT9   Protocadherin 13 -  Homo sapiens     16 . . . 962   946/947 (99%)   0.0           (Human), 947 aa (fragment).    1 . . . 947   946/947 (99%)       Q8N6Y1   Protocadherin 20 -  Homo sapiens     39 . . . 962    924/924 (100%)   0.0           (Human), 924 aa.    1 . . . 924    924/924 (100%)       Q8BIV2   PROTOCADHERIN 13 homolog -   13 . . . 962   877/951 (92%)   0.0             Mus musculus  (Mouse), 952 aa.    2 . . . 952   913/951 (95%)       Q8BIZ0   PROTOCADHERIN 13 homolog -   39 . . . 962   861/925 (93%)   0.0             Mus musculus  (Mouse), 925 aa.    1 . . . 925   897/925 (96%)                  
 
      PFam analysis predicts that the NOV47a protein contains the domains shown in the Table 47F.  
               TABLE 47F                          Domain Analysis of NOV47a                                             Identities/                       Similarities           Pfam   NOV47a   for the   Expect           Domain   Match Region   Matched Region   Value                       cadherin   225 . . . 322   36/111 (32%)   1.3e−08                   73/111 (66%)           cadherin   336 . . . 428   27/110 (25%)   0.0004                   66/110 (60%)           cadherin   551 . . . 641   33/107 (31%)   6.4e−19                   69/107 (64%)           cadherin   655 . . . 744   39/107 (36%)   5.8e−20                   69/107 (64%)           cadherin   762 . . . 855   38/112 (34%)     4e−11                   70/112 (62%)                      
 
     Example 48  
      The NOV48 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 48A.  
               TABLE 48A                       NOV48 Sequence Analysis                                                NOV48a, CG57574-03   SEQ ID NO: 1053   1012 bp           DNA Sequence   ORF Start: ATG at 23   ORF Stop: TAG at 1010                       AGAGACCAGGTTCTGAGAAGCA   ATG GTGACGAAGGCCTTTGTCTTGTTGGCCATCTTTGCAGAAGCCT           CTGCAAAATCGTGTGCTCCAAATAAAGCAGATGTCATTCTTGTGTTTTGCTATCCCAAAACCATCATC       ACCAAAATCCCCGAGTGTCCCTATGGATGGGAAGTTCATCAGCTGGCCCTCGGAGGGCTGTGTTACAA       TGGGGTCCACGAAGGAGGTTACTACCAATTTGTGATCCCAGATTTATCACCTAAAAACAAGTCCTATT       GTGGAACCCAGTCTGAGTACAAGCCACCTATCTATCACTTCTACAGTCACATCGTTTCCAATGACACC       ACAGTGATTGTAAAAAACCAGCCTGTCAACTACTCCTTCTCCTGCACCTACCACTCCACCTACTTGGT       GAACCAGGCTGCCTTTGACCAGAGAGTGGCCACTGTTCACGTGAAGAACGGGAGCATGGGCACATTTG       AGAGCCAACTGTCTCTCAACTTCTACACTAATGCCAAGTTCTCCATCAAGAAAGAAGCTCCCTTTGTC       CTGGAGGCATCGGAAATCGGTTCAGATCTGTTTGCAGGAGTGGAAGCCAAAGGGTTAAGCATTAGGTT       TAAAGTGGTCTTGAACAGCTGTTGGGCCACCCCCTCGGCTGACTTCATGTATCCCTTGCAGTGGCAGC       TGATCAACAAGGGCTGCCCCACGGATGAAACCGTCCTCGTGCATGAGAATGGGAGAGATCACAGGGCA       ACCTTCCAATTCAATGCTTTCCGGTTCCAGAACATCCCCAAACTCTCCAAGGTGTGGTTACACTGTGA       GACGTTCATCTGCGACAGTGAGAAACTCTCCTGCCCAGTGACCTGCGATAAACGGAAGCGCCTCCTGC       GAGACCAGACCGGGGGAGTCCTGGTCGTGGAGCTCTCCCTGCGGAGCAGGGGATTTTCCAGTCTCTAT       AGCTTCTCAGATGTTCTCCACCACCTCATCATGATGTTGGGGATTTGTGCCGTGTTA TAG                                           NOV48a, CG57574-03   SEQ ID NO: 1054   329 aa   MW at 36955.2kD           Protein Sequence                     MVTKAFVLLAIFAEASAKSCAPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCYNGVHEGGY           YQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDTTVIVKNQPVNYSFSCTYHSTYLVNQAAFDQ       RVATVHVKNGSMGTFESQLSLNFYTNAKFSIKKEAPFVLEASEIGSDLFAGVEAKGLSIRFKVVLNSC       WATPSADFMYPLQWQLINKGCPTDETVLVHENGRDHRATFQFNAFRFQNIPKLSKVWLHCETFICDSE       KLSCPVTCDKRKRLLRDQTGGVLVVELSLRSRGFSSLYSFSDVLHHLIMMLGICAVL                                     NOV48b, CG57574-01   SEQ ID NO: 1055   1026 bp           DNA Sequence   ORF Start: ATG at 85   ORF Stop: TAG at 985                       GATCGAGGCTCAGGCCCTGGAAGGACCGTAAACATTTGGCCAGCTTGGTTTGGATACCTGGCAGAGAC               CAGGTTCTGAGAAGCA   ATG GTGACGAAGGCCTTTGTCTTGTTGGCCATCTTTGCAGAAGCCTCTGCAA       AATCGTGTGCTCCAAATAAAGCAGATGTCATTCTTGTGTTTTGCTATCCCAAAACCATCATCACCAAA       ATCCCCGAGTGTCCCTATGGATGGGAAGTTCATCAGCTGGCCCTCGGAGGGCTGTGTTACAATGGGGT       CCACGAAGGAGGTTACTACCAATTTGTGATCCCAGATTTATCACCTAAAAACAAGTCCTATTGTGGAA       CCCAGTCTGAGTACAAGCCACCTATCTATCACTTCTACAGTCACATCGTTTCCAATGACACCACAGTG       ATTGTAAAAAACCAGCCTGTCAACTACTCCTTCTCCTGCACCTACCACTCCACCTACTTGGTGAACCA       GGCTGCCTTTGACCAGAGTGTCAATTTCCTTCCAAAGAATGCCAAGTTCTCCATCAAGAAAGAAGCTC       CCTTTGTCCTGGAGGCATCCGAAATCGGTTCAGATCTGTTTGCAGGAGTGGAAGCCAAAGGGTTAAGC       ATTAGGTTTAAAGTGGTCTTGAACAGCTGTTGGGCCACCCCCTCGGCTGACTTCATGTATCCCTTGCA       GTGGCAGCTGATCAACAAGGGCTGCCCCACGGATGAAACCGTCCTCGTGCATGAGAATGGGAGAGATC       ACAGGGCAACCTTCCAATTCAATGCTTTCCGGTTCCAGAACATCCCCAAACTCTCCAAGGTGTGGTTA       CACTGTGAGACGTTCATCTGCGACAGTGAGAAACTCTCCTGCCCAGTGACCTGCGATAAACGGAAGCG       CCTCCTGCGAGACCAGACCGGGGGAGTCCTGGTCGTGGAGCTCTCCCTGCGGAATGTTCTCCACCACC       TCATCATGATGTTGGGGATTTGTGCCGTGTTA TAG   GAGTTAGCCAGGCAGCTGCCGCTCCTCCACCCA           CAATAG                                           NOV48b, CG57574-01   SEQ ID NO: 1056   300 aa   MW at 33751.8kD           Protein Sequence                     MVTKAFVLLAIFAEASAKSCAPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCYNGVHEGGY           YQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDTTVIVKNQPVNYSFSCTYHSTYLVNQAAFDQ       SVNFLPKNAKFSIKKEAPFVLEASEIGSDLFAGVEAKGLSIRFKVVLNSCWATPSADFMYPLQWQLIN       KGCPTDETVLVHENGRDHEATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVTCDKRKRLLRDQ       TGGVLVVELSLRNVLHHLIMMLGICAVL                                     NOV48c, CG57574-02   SEQ ID NO: 1057   1012 bp           DNA Sequence   ORF Start: ATG at 23   ORF Stop: TAG at 1010                       AGAGACCAGGTTCTGAGAAGCA   ATG GTGACGAAGGCCTTTGTCTTGTTGGCCATCTTTGCAGAAGCCT           CTGCAAAATCGTGTGCTCCAAATAAAGCAGATGTCATTCTTGTGTTTTGCTATCCCAAAACCATCATC       ACCAAAATCCCCGAGTGTCCCTATGGATGGGAAGTTCATCAGCTGGCCCTCGGAGGGCTGTGTTACAA       TGGGGTCCACGAAGGAGGTTACTACCAATTTGTGATCCCAGATTTATCACCTAAAAACAAGTCCTATT       GTGGAACCCAGTCTGAGTACAAGCCACCTATCTATCACTTCTACAGTCACATCGTTTCCAATGACGCC       ACAGTGATTGTAAAAAACCAGCCTGTCAACTACTCCTTCTCCTGCACCTACCACTCCACCTACTTGGT       GAACCAGGCTGCCTTTGACCAGAGAGTGGCCACTGTTCACGTGAAGAACGGGAGCATGGGCACATTTG       AGAGCCAACTGTCTCTCAACTTCTACACTAATGCCAAGTTCTCCATCAAGAAAGAAGCTCCCTTTGTC       CTGGAGGCATCCGAAATCGGTTCAGATCTGTTTGCAGGAGTGGAAGCCAAAGGGTTAAGCATTAGGTT       TAAAGTGGTCTTGAACAGCTGTTGGGCCACCCCCTCGGCTGACTTCATGTATCCCTTGCAGTGGCAGC       TGATCAACAAGGGCTGCCCCACGGATGAAACCGTCCTCGTGCATGAGAATGGGAGAGATCACAGGGCA       ACCTTCCAATTCAATGCTTTCCGGTTCCAGAACATCCCCAAACTCTCCAAGGTGTGGTTACACTGTGA       GACGTTCATCTGCGACAGTGAGAAACTCTCCTGCCCAGTGACCTGCGATAAACGGAAGCGCCTCCTGC       GAGACCAGACCGGGGGAGTCCTGGTCGTGGAGCTCTCCCTGCGGAGCAGGGGATTTTCCAGTCTCTAT       AGCTTCTCAGATGTTCTCCACCACCTCATCATGATGTTGGGGATTTGTGCCGTGTTA TAG                                           NOV48c, CG57574-02   SEQ ID NO: 1058   329 aa   MW at 36925.2kD           Protein Sequence                     MVTKAFVLLAIFAEASAKSCAPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCYNGVHEGGY           YQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDATVIVKNQPVNYSFSCTYHSTYLVNQAAFDQ       RVATVHVKNGSMGTFESQLSLNFYTNAKFSIKKEAPFVLEASEIGSDLFAGVEAKGLSIRFKVVLNSC       WATPSADFMYPLQWQLINKGCPTDETVLVHENGRDHRATFQFNAFRFQNIPKLSKVWLHCETFICDSE       KLSCPVTCDKRKRLLRDQTGGVLVVELSLRSRGFSSLYSFSDVLHHLIMMLGICAVL                                     NOV48d, CG57574-04   SEQ ID NO: 1059   840 bp           DNA Sequence   ORF Start: at 7   ORF Stop: at 835                       GGATCC AAATCGTGTGCTCCAAATAAAGCAGATGTCATTCTTGTGTTTTGCTATCCCAAAACCATCAT           CACCAAAATCCCCGAGTGTCCCTATGGATGGGAAGTTCATCAGCTGGCCCTCGGAGGGCTGTGTTACA       ATGGGGTCCACGAAGGAGGTTACTACCAATTTGTGATCCCAGATTTATCACCTAAAAACAAGTCCTAT       TGTGGAACCCAGTCTGAGTACAAGCCACCTATCTATCACTTCTACAGTCACATCGTTTCCAATGACAC       CACAGTGATTGTAAAAAACCAGCCTGTCAACTACTCCTTCTCCTGCACCTACCACTCCACCTACTTGG       TGAACCAGGCTGCCTTTGACCAGAGAGTGGCCACTGTTCACGTGAAGAACGGGAGCATGGGCACATTT       GAGAGCCAACTGTCTCTCAACTTCTACACTAATGCCAAGTTCTCCATCAAGAAAGAAGCTCCCTTTGT       CCTGGAGGCATCGGAAATCGGTTCAGATCTGTTTGCAGGAGTGGAAGCCAAAGGGTTAAGCATTAGGT       TTAAAGTGGTCTTGAACAGCTGTTGGGCCACCCCCTCGGCTGACTTCATGTATCCCTTGCAGTGGCAG       CTGATCAACAAGGGCTGCCCCACGGATGAAACCGTCCTCGTGCATGAGAATGGGAGAGATCACAGGGC       AACCTTCCAATTCAATGCTTTCCGGTTCCAGAACATCCCCAAACTCTCCAAGGTGTGGTTACACTGTG       AGACGTTCATCTGCGACAGTGAGAAACTCTCCTGCCCAGTGACCTGCGATAAACGGAAGCGCCTCCTG       CGAGACCAGACCGGGGGACTC GAG                                           NOV48d, CG57574-04   SEQ ID NO: 1060   276 aa   MW at 31202.3kD           Protein Sequence                     KSCAPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCYNGVHEGGYYQFVIPDLSPKNKSYCG           TQSEYKPPIYHFYSHIVSNDTTVIVKNQPVNYSFSCTYHSTYLVNQAAFDQRVATVHVKNGSMGTFES       QLSLNFYTNAKFSIKKEAPFVLEASEIGSDLFAGVEAKGLSIRFKVVLNSCWATPSADFMYPLQWQLT       NKGCPTDETVLVHENGRDHPATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVTCDKRKRLLRD       QTGG                                     NOV48e, CG57574-05   SEQ ID NO: 1061   821 bp           DNA Sequence   ORF Start: at 1   ORF Stop: at 820                     GGATCCAAATCGTGCGCTCCAAATAAAGCAGATGTCATTCTTGTGTTTTGCTATCCCAAAACCATCAT           CACCAAAATCCCCGAGTGTCCCTATGGATGGGAAGTTCATCAGCTGGCCCTCGGAGGGCTGTGTTACA       ATGGGGTCCACGAAGGAGGTTACTACCAATTTGTGATCCCAGATTTATCACCTAAAAACAAGTCCTAT       TGTGGAACCCAGTCTGAGTACAAGCCACCTATCTATCACTTCTACAGTCACATCGTTTCCAATGACAC       CACAGTGATTGTAAAAAACCAGCCTGTCAACTACTCCTTCTCCTGCACCTACCACTCCACCTACTTGG       TGAACCAGGCTGCCTTTGACCAGAGAGTGGCCACTGTTCACGTGAAGAACGGGAGCATGGGCACATTT       GAGAGCCAACTGTCTCTCAACTTCTACACTAATGCCAAGTTCTCCATCAAGAAAGAAGCTCCCTTTGT       CCTGGAGGCATCCGAAATCGGTTCAGATCTGTTTGCAGGAGTGGAAGCCAAAGGGTTAAGCATTAGGT       TTAAAGTGGTCTTGAACAGCTGTTGGGCCACCCCCTCGGCTGACTTCATGTATCCCTTGCAGTGGCAG       CTGATCAACAAGGGCTGCCCCACGGATGAAACCGTCCTCGTGCATGAGAATGGGAGAGATCACAGGGC       AACCTTCCAATTCAATGCTTTCCGGTTCCAGAACATCCCCAAACTCTCCAAGGTGTGGTTACACTGTG       AGACGTTCATCTGCGACAGTGAGAAACTCTCCTGCCCAGTGACCTGCGATAAACGGAAGCGCCTCCTG       CGAGA                                         NOV48e, CG57574-05   SEQ ID NO: 1062   273 aa   MW at 30888.0kD           Protein Sequence                     GSKSCAPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCYNGVHEGGYYQFVIPDLSPKNKSY           CGTQSEYKPPIYHFYSHIVSNDTTVIVKNQPVNYSFSCTYHSTYLVNQAAFDQRVATVHVKNGSMGTF       ESQLSLNFYTNAKFSIKKEAPFVLEASEIGSDLFAGVEAKGLSIRFKVVLNSCWATPSADFMYPLQWQ       LINKGCPTDETVLVHENGRDHRATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVTCDKRKRLL       R                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 48B.  
               TABLE 48B                       Comparison of the NOV48 protein sequences.                                            NOV48a   MVTKAFVLLAIFAEASAKSCAPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCY           NOV48b   MVTKAFVLLAIFAEASAKSCAPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCY       NOV48c   MVTKAFVLLAIFAEASAKSCAPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCY       NOV48d   -----------------KSCAPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCY       NOV48e   ---------------GSKSCAPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCY               NOV48a   NGVHEGGYYQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDTTVIVKNQPVNYSFS       NOV48b   NGVHEGGYYQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDTTVIVKNQPVNYSFS       NOV48c   NGVHEGGYYQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDATVIVKNQPVNYSFS       NOV48d   NGVHEGGYYQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDTTVIVKNQPVNYSFS       NOV48e   NGVHEGGYYQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDTTVIVKNQPVNYSFS               NOV48a   CTYHSTYLVNQAAFDQRVATVHVKNGSMGTFESQLSLNFYTNAKFSIKKEAPFVLEASEI       NOV48b   CTYHSTYLVNQAAFDQSVNFLPK-----------------N-AKFSIKKEAPFVLEASEI       NOV48c   CTYHSTYLVNQAAFDQRVATVHVKNGSMGTFESQLSLNFYTNAKFSIKKEAPFVLEASEI       NOV48d   CTYHSTYLVNQAAFDQRVATVHVKNGSMGTFESQLSLNFYTNAKFSIKKEAPFVLEASEI       NOV48e   CTYHSTYLVNQAAFDQRVATVHVKNGSMGTFESQLSLNFYTNAKFSIKKEAPFVLEASEI               NOV48a   GSDLFAGVEAKGLSIRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDETVLVHENGRDH       NOV48b   GSDLFAGVEAKGLSIRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDETVLVHENGRDH       NOV48c   GSDLFAGVEAKGLSIRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDETVLVHENGRDH       NOV48d   GSDLFAGVEAKGLSIRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDETVLVHENGRDH       NOV48e   GSDLFAGVEAKGLSIRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDETVLVHENGRDH               NOV48a   RATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVTCDKRKRLLRDQTGGVLVVELS       NOV48b   RATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVTCDKRKRLLRDQTGGVLVVELS       NOV48c   RATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVTCDKRKRLLRDQTGGVLVVELS       NOV48d   RATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVTCDKRKRLLRDQTGG-------       NOV48e   RATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVTCDKRKRLLR------------               NOV48a   LRSRGFSSLYSFSDVLHHLIMMLGICAVL       NOV48b   LRNVLHHLIMMLGICAVL-----------       NOV48c   LRSRGFSSLYSFSDVLHHLIMMLGICAVL       NOV48d   -----------------------------       NOV48e   -----------------------------               NOV48a   (SEQ ID NO: 1054)       NOV48b   (SEQ ID NO: 1056)       NOV48c   (SEQ ID NO: 105B)       NOV48d   (SEQ ID NO: 1060)       NOV48e   (SEQ ID NO: 1062)                  
 
      Further analysis of the NOV48a protein yielded the following properties shown in Table 48C.  
               TABLE 48C                       Protein Sequence Properties NOV48a                                        SignalP analysis:   Cleavage site between residues 18 and 19       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 4; pos. chg 1; neg. chg 0           H-region:   length 9; peak value 11.46           PSG score:   7.06                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 0.86           possible cleavage site: between 17 and 18                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 17)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 18           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 0                             PERIPHERAL   Likelihood = 2.76 (at 25)                         ALOM score: −1.44 (number of TMSs: 0)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 8           Charge difference: −2.0 C(0.0)-N(2.0)           N &gt;= C: N-terminal side will be inside       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   8.58           Hyd Moment(95):   5.88   G content:   0           D/E content:   2   S/T content:   3                         Score: −5.83       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: KRKR (5) at 282           pat7: none           bipartite: none           content of basic residues: 9.4%           NLS Score: −0.16       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: CaaX motif in the C-terminus: CAVL       if X is S, A, or M, it will be farnesylated       otherwise, it will be geranylgeranylated       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear           discrimination           Prediction: cytoplasmic           Reliability: 94.1       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         33.3%: endoplasmic reticulum           22.2%: mitochondrial           11.1%: cytoplasmic           11.1%: vacuolar           11.1%: nuclear           11.1%: extracellular, including cell wall                 &gt;&gt; prediction for CG57574-03 is end (k = 9)                  
 
      A search of the NOV48a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 48D.  
               TABLE 48D                          Geneseq Results for NOV48a                                         NOV48a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               AAE17314   Human tectorin beta protein,    1 . . . 329    329/329 (100%)   0.0           sbg453915TECTORINa -  Homo      1 . . . 329    329/329 (100%)             sapiens , 329 aa. [WO200198342-A1,           27-DEC-2001]       ABG72418   Cytochrome b45.65 - Unidentified, 415   14 . . . 285    84/299 (28%)   3e−17           aa. [CN1345764-A, 24-APR-2002]   27 . . . 318   131/299 (43%)       AAE17559   Human pancreatic tumour protein, GP-   77 . . . 282    62/215 (28%)   1e−12           2 -  Homo sapiens , 530 aa.   270 . . . 472    101/215 (46%)           [WO200194409-A2, 13-DEC-2001]       AAB54274   Human pancreatic cancer antigen   77 . . . 282    62/215 (28%)   1e−12           protein sequence SEQ ID NO: 726 -   146 . . . 348    101/215 (46%)             Homo sapiens , 406 aa.           [WO200055320-A1, 21-SEP-2000]       AAR98963   Human GP2 pancreatic glycoprotein -   77 . . . 282    62/215 (28%)   1e−12             Homo sapiens , 384 aa. [WO9617873-   124 . . . 326    101/215 (46%)           A1, 13-JUN-1996]                  
 
      In a BLAST search of public sequence databases, the NOV48a protein was found to have homology to the proteins shown in the BLASTP data in Table 48E.  
               TABLE 48E                          Public BLASTP Results for NOV48a                                         NOV48a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             Q96PL2   Tectorin beta -  Homo sapiens     1 . . . 329   329/329   (100%)   0.0           (Human), 329 aa.   1 . . . 329   329/329   (100%)       O08524   Beta tectorin -  Mus musculus     1 . . . 329   310/329   (94%)   0.0           (Mouse), 329 aa.   1 . . . 329   317/329   (96%)       P54097   Beta-tectorin precursor -  Gallus     1 . . . 329   242/329   (73%)    e−150             gallus  (Chicken), 329 aa.   1 . . . 328   286/329   (86%)       Q95JJ6   Hypothetical 45.5 kDa protein -   14 . . . 285    85/299   (28%)   4e−17             Macaca fascicularis  (Crab eating   27 . . . 318    131/299   (43%)           macaque) (Cynomolgus monkey),           415 aa.       Q8TCW7   Hypothetical protein -  Homo sapiens     14 . . . 285    84/299   (28%)   5e−17           (Human), 431 aa.   43 . . . 334    131/299   (43%)                  
 
      PFam analysis predicts that the NOV48a protein contains the domains shown in the Table 48F.  
               TABLE 48F                          Domain Analysis of NOV48a                                             Identities/                       Similarities       Pfam   NOV48a       for the   Expect       Domain   Match Region       Matched Region   Value                                         zona_pellucida   19 . . . 283   55/310   (18%)   8.2e−49               190/310   (61%)                  
 
     Example 49  
      The NOV49 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 49A.  
               TABLE 49A                       NOV49 Sequence Analysis                                                        NOV49a, CG57689-01   SEQ ID NO: 1063   1933 bp               DNA Sequence   ORF Start: ATG at 75   ORF Stop: TAA at 1881                       GGTCGGCTGCCCCGAGGGCTTTGAGCTGGACTCCCAGGGAGCGTTTTGTGTGGGTGAGCGCCCCCAAC               CCTGGC   ATG GATGTGGGAGGCCTCTCAGCCTGGGATGGATGGCTTCTCCCAGCCAGCTGGCAGGAGGG       CCTGGGAGCGGAGACCACCAGACCCCTTCCTGCCCCAGACAGGGACGAGTGCTCAGGAGGCCCTAGCC       CCTGCTCCCATGCCTGCCTTAATGCACCCGGCCGCTTCTCCTGCACCTGCCCCACTGGCTTCGCCCTG       GCCTGGGATGACAGGAACTGCAGAGATGTGGACGAGTGTGCGTGGGATGCTCACCTCTGCCGAGAGGG       ACAGCGCTGTGTGAACCTGCTCGGGTCCTACCGCTGCCTCCCCGACTGTGGGCCTGGCTTCCGGGTGG       CTGATGGGGCCGGCTGTGAAGATGTGGACGAATGCCTGGAGGGGTTGGACGACTGTCACTACAACCAG       CTCTGCGAGAACACCCCAGGCGGTCACCGCTGCAGCTGCCCCAGGGGTTACCGGATGCAGGGCCCCAG       CCTGCCCTGCCTAGATGTCAATGAGTGCCTGCAGCTGCCCAAGGCCTGCGCCTACCAGTGCCACAACC       TCCAGGGCAGCTACCGCTGCCTGTGCCCCCCAGGCCAGACCCTCCTTCGCGACGGCAAGGCCTGCACC       TCACTGGAGCGGAATGGACAAAATGTGACCACCGTCAGCCACCGAGGCCCTCTATTGCCCTGGCTGCG       GCCCTGGGCCTCGATCCCCGGTACCTCCTACCACGCCTGGGTCTCTCTCCGTCCGGGTCCCATGGCCC       TGAGCAGTGTGGGCCGGGCCTGGTGCCCTCCTGGTTTCATCAGGCAGAACGGAGTCTGCACAGACCTT       GACGAGTGCCGCGTGAGGAACCTGTGTCAGCACGCCTGCCGCAACACTGAGGGCAGCTACCAGTGCCT       GTGCCCACGCCGGCTACCGTCTGCTCCCCAGCGGGAAGAACTGCCAGGACATCAACGAGTGCGAGGAG       GAGAGCATCGAGTGTGGACCCGGCCAGATGTGCTTCAACACCCGTGGCAGCTACCAGTGTGTGGACAC       ACCCTGTCCTGCCACCTACCGGCAGGGCCCCAGCCCTGGGACGTGCTTCCGGCGCTGCTCGCAGGACT       GCGGCACGGGCGGCCCCTCTACGCTGCAGTACCGGCTGCTGCCGCTGCCCCTGGGCGTGCGCGCCCAC       CACGACGTGGCCCGCCTCACCGCCTTCTCCGAGGTCGGCGTCCCCGCCAACCGCACCGAGCTCAGCAT       GCTGGAGCCCGACCCCCGCAGCCCCTTCGCGCTGCGTCCGCTGCGCGCGGGCCTTGGCGCGGTCTACA       CCCGTCGCGCGCTCACCCGCGCCGGCCTCTACCGGCTCACCGTGCGTGCTGCGGCACCGCGCCACCAA       AGCGTCTTCGTCTTGCTCATCGCCGTGTCCCCCTACCCCTACTAAACGGGAGAGGGCATTGGCGGCCG       CCCTGGCGTGACCCCCGAGGAAGGGGTCGAGGAGAAGCTTGGTCCACGCCACCTGCTGTGGCAAGCGG       AGCGTCATCGTCTCCCGCCCCGTGCGTCAGCGAGACCTTGGGTCAACACGACCCTGCGCACAGCCTTG       ACCCCCGACAGCGAGGACCTGACCTCACAGAGGGAGGCGTCCAGGGCGGCCCTTGGGTGGCCAGTCCC       GCAGGCAGGGCCCGGGGAAGCCCGGATCAGACCTCCAGGTCTGATCCGCCCCTCAGTGGGAGCGGGAC       AGGGACACAGGGCACCTGGACGCGCGGGAGAGGGGGCAGACCCCGCGTTAGGGGTGGCAGCAGCTGTC       GCCCGGCCACACCTGGTGGTGTCATTCTGAACCCTGTTGCAATA TAA   AGGGATTTTTTTTTAACCAAC           TTGGTTTCTTTGTCTAATTATTTTGCTTT                                                   NOV49a, CG57689-01   SEQ ID NO: 1064   602 aa   MW at 65011.8kD               Protein Sequence                     MDVGGLSAWDGWLLPASWQEGLGAETTRPLPAPDRDECSGGPSPCSHACLNAPGRFSCTCPTGFALAW           DDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAGCEDVDECLEGLDDCHYNQLC       ENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPGQTLLRDGKACTSL       ERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDE       CRVRNLCQHACRNTEGSYQCLCPRRLPSAPQREELPGHQRVRGGEHRVWTRPDVLQHPWQLPVCGHTL       SCHLPAGPQPWDVLPALLAGLRHGRPLYAAVPAAAAAPGRARPPRRGPPHRLLRGRRPRQPHRAQHAG       ARPPQPLRAASAARGPWRGLHPSRAHPRRPLPAHRACCGTAPPKRLRLAHRRVPLPLLNGRGHWRPPW       RDPRGRGRGEAWSTPPAVASGASSSPAPCVSETLGQHDPAHSLDPRQRGPDLTEGGVQGGPWVASPAG       RARGSPDQTSRSDPPLSGSGTGTQGTWTRGRGGRPRVRGGSSCRPATPGGVILNPVAI                  
 
      Further analysis of the NOV49a protein yielded the following properties shown in Table 49B.  
               TABLE 49B                       Protein Sequence Properties NOV49a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 10; pos. chg 0; neg. chg 2           H-region:   length 9; peak value 0.00           PSG score:   −4.40                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −3.99           possible cleavage site: between 23 and 24                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 0           number of TMS(s) . . . fixed                             PERIPHERAL   Likelihood = 7.80 (at 586)                         ALOM score: 7.80 (number of TMSs: 0)       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   3.89           Hyd Moment(95):   4.99   G content:   2           D/E content:   2   S/T content:   1                         Score: −8.14       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: RRPR (4) at 396           pat7: PPKRLRL (4) at 450           pat7: PKRLRLA (5) at 451           bipartite: none           content of basic residues: 12.3%           NLS Score: 0.55       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear           discrimination           Prediction: nuclear           Reliability: 94.1       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         73.9%: nuclear           17.4%: cytoplasmic            4.3%: mitochondrial            4.3%: peroxisomal                 &gt;&gt; prediction for CG57689-01 is nuc (k = 23)                  
 
      A search of the NOV49a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 49C.  
               TABLE 49C                          Geneseq Results for NOV49a                                         NOV49a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               ABU07377   Human protein NOV9 -  Homo sapiens ,   34 . . . 307   266/277 (96%)   e−172           3931 aa. [WO200285922-A2, 31-OCT-   3500 . . . 3776    269/277 (97%)           2002]       ABP69271   Human polypeptide SEQ ID NO 1318 -   34 . . . 307   266/277 (96%)   e−172             Homo sapiens , 939 aa.   508 . . . 784    269/277 (97%)           [WO200270539-A2, 12-SEP-2002]       ABG34007   Human secreted protein #4 encoded by   60 . . . 307   231/251 (92%)   e−146           gene 57 -  Homo sapiens , 638 aa.   233 . . . 483    234/251 (93%)           [WO200226931-A2, 04-APR-2002]       ABG33919   Human secreted protein encoded by   60 . . . 307   231/251 (92%)   e−146           gene 57 #1 -  Homo sapiens , 575 aa.   170 . . . 420    234/251 (93%)           [WO200226931-A2, 04-APR-2002]       AAE06183   Human gene 57 encoded secreted   60 . . . 307   231/251 (92%)   e−146           protein fragment, SEQ ID NO: 245 -   233 . . . 483    234/251 (93%)             Homo sapiens , 638 aa.           [WO200151504-A1, 19-JUL-2001]                  
 
      In a BLAST search of public sequence databases, the NOV49a protein was found to have homology to the proteins shown in the BLASTP data in Table 49D.  
               TABLE 49D                          Public BLASTP Results for NOV49a                                         NOV49a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q8BNH3   Inferred: hemicentin -  Mus     34 . . . 546   285/541 (52%)    e−148             musculus  (Mouse), 729 aa.   229 . . . 729    314/541 (57%)       Q8K061   Hypothetical protein -  Mus     34 . . . 307   212/278 (76%)    e−135             musculus  (Mouse), 787 aa.   355 . . . 632    229/278 (82%)       Q96SC3   Fibulin-6 -  Homo sapiens     26 . . . 317   124/302 (41%)   5e−62           (Human), 2673 aa (fragment).   2222 . . . 2506    159/302 (52%)       Q96RW7   Hemicentin -  Homo sapiens     26 . . . 317   122/302 (40%)   1e−60           (Human), 5636 aa.   5185 . . . 5469    158/302 (51%)       Q96K89   Hypothetical protein FLJ14438 -   34 . . . 317   114/297 (38%)   4e−48             Homo sapiens  (Human), 741 aa.   330 . . . 574    147/297 (49%)                  
 
      PFam analysis predicts that the NOV49a protein contains the domains shown in the Table 49E.  
               TABLE 49E                          Domain Analysis of NOV49a                                             Identities/                       Similarities           Pfam   NOV49a   for the   Expect           Domain   Match Region   Matched Region   Value                       EGF   38 . . . 73   14/47 (30%)   2.9e−07                   29/47 (62%)           EGF   123 . . . 160   14/47 (30%)   0.86                   24/47 (51%)           EGF   166 . . . 201   15/47 (32%)   8.6e−06                   26/47 (55%)                      
 
     Example 50  
      The NOV50 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 50A.  
               TABLE 50A                       NOV50 Sequence Analysis                                                        NOV50a, CG58567-01   SEQ ID NO: 1065   3373 bp               DNA Sequence   ORF Start: at 1   ORF Stop: TGA at 3190                     TTGATTGTCCAAGCCACAGATAAAGGGATGCCCAGGCTTTCTAATACGACTGTAATCAAGGTACAGGT           GACTGATATAAATGACAATGCCCCAGCTTTTCTCCCCTCTGAAGCAGTGGAAATTACAGAAGTCATGA       CTATTTCAGAAGATTCTTTGCCTGGTGTAATTGTGACTCATGTGTCAGTTCATGATGTGGATTTGAAT       TCAGCTTTCATATTCAGTTTTGCCAAAGAGAGTAATCCTGGAACCAAGTTTGCTATTGATCAGAACAC       TGGAGTGGTGGTGTTGGTGAAAACATTGGATTTTGAAGAAATGACTGAATATGAGCTGCTCATCCAAA       TTTCTGATTCAGTGCACTACACAGAGGGAGCACTTGTAGTCCGTGTGCTGGATGTCAATGATAATCCA       CCAGTGTTTTCTCAAGATTTCTATCAGGTCACAGTTCCTGAATCAATACCTGTGGGGTATTCAGTGCT       GACTCTGTCAGCCACAGACTTAGAAAGCAATGAGAACATTTCTTACAGAATTCTATCCTCTTCTAAGG       AATTCTCCATTGATCCTAAGAATGGCACAATATTTACTATCAGTCCCGTATTACTTCTGGATACAATA       TCAACAACTCGATTTCTTGTGGAAGCCAGTGATGGTGGAAATCCTGACCCGAGAGCTCTTACTTTAGT       GGAGATAGGAATAGAAGATATGAACAATTATGCCCCTGAATTCACAGTCAAATCCTATAATCTTAGCC       TAAGTGAGGATGCTCTGGTTGGAAGCACGCTTGTTACATTTTCAAACATCGACCATGACTGGACCCGT       GAAAACACATATGTTGAATATTCCATCATCAGTGGTAATTCACAGAACAATTTTCATGTGGAAACTAA       GTTCTTTCATTCAGAATATCCTTATAAGCAAGTCGGTTATCTTGTGTTGCTTCACAGTCTGGACAGAG       AAGCAAGTGCTAGCCATGAGCTTGTCATTCTGGCATCTGACAGTGGCTGCCCTCCATTGAGTTCCACA       GCTGTCATATCAATACAAGTACTTGATGTCAATGACAATCCCCCAAACTTCAGCAGCCTGAGCTATCA       CACCCATGTCAAGGAAAGCACCCCTCTAGGGAGTCACATCACTGTGGTCTCAGCAAATGACCGTGACA       CAGGGTCACATGCAGAAATCATCTACAACATCATCTCTGGAAATGAGAAGGGACATTTTTACTTAGAA       GAAAACACTGGAGTTCTTTATTTGATTAAACCTCTGGATTATGAAAAAATGACAAAATTCACCTTAAC       TGTCCAAGCTTCAGATGCAGAAAAGAAACATTTTTCTTTTGCAGTTGTGTTTGTCAGTGTCCTGGATG       ATAACGACCATGCACCTCAGTTTATGTTCTCAAGCTTCAGCTGTATTGTTCCAGAAAATCTGCCTATT       TCCTCTACCATATGCTCTATAAATGCTCTGGATTTTGATGCTGGTCCGTATGGAGAATTGACCTATTC       TATTGTATCACCCTGTTTTCTCACTCATGGAATGTCTTATGATCATGATCTCTTCCTCATTGACCCTT       TGACAGGGGATATTCATGCTAAGCAAATCCTTGACTATGAAAATGGCAATAAATACTGCCTCACAGTC       CAAGCCAAAGACAAAGGTGATGCAACTGCCTCCTTAGTGGTCTGGGTGGATATTGAAGGGATAGATGA       ATTTGAGCCCATTTTCACTCAAGATCAGTATTTTTTCACCCTCCCAGAAAAGAATAAAGACAGACAGT       TGATTGGCAGAGTGGAAGCCTCAGATGCAGATGCTGGTATTGATGGAGTCATTCTTTACTCCCTTGGA       ACCTCATCTCCTTTCTTTTCAGTAAATAGAACCAATGGAAATATTTATTTGATTAGAGCCCTTCCCCT       AATAAAAAGTCAACTCAACAAAGAAGACACCTTGGAAATGAAAATAATCGCTCATAGTCCCAAATCAG       ATTCCAAGTTTGCATCTTGCACTGTTTTTGTGAATGTGTCTTTCTCCTCTGAAGGAACACCCTTGGCA       GTGTTCGCCAGCAGCTTTTCAATCAGCCTGGTGGTCTCCTTTTTAGTGTTTCTGATACTCATCTGCAT       TCTAATTGTAATGATTTTAAGACATAAACAAAAAGACACAATAAACAATTATGAGGAGAAGAAAACCT       CATCTTTAGATGCGGACTTGAGAGTGACCCGGGATGCCAGTGTGCTCAAAGCCTTCCAGAAAACTGAC       GACTGCAGTAACGAGGTGGTCCCTGTGGATGCCACTCCGGAATGGTTGAGTTTAATAAGTATCATGGA       GAAGGATATTGTCAATCTGTACAGATACTCAAACTCCAGTGGCCACTGTTCTGTGGAAGGAGAAACTG       CAGAAGATAAGGAAATCCAGAGGATAAATGAGCATCCCTACAGAAAGTGCTCAGACTCAGCTCTGAGT       GACCACGAGTCCAGGGTGCCAGACTCGGGTATCCCGAGGGACTCAGACCAGCTCTCCTGCCTATCTGG       GGAAACTGATGTGATGGTGACTGCCGAAACAGCAGAAGCCAGCCAAACATTTGGGGAAGGAGATCAAG       GGGAAGGCTGCAGCACCACCTGTGCTCAAAATAATGTGTTACCCCAGACAGTTCAGAAGAGAGAGGCA       AAAGAGAGCATCCTGGCTGACGTTAGAAAAGAGTCTGTCTTTATTTCAGGTGATCAGGAAGTAAGGTG       TGCAGCTCTTTCAACTCAGACGACCTCTGATCATGATGGAAAAGACAACTATCACTGGAATTATCTTC       TTAGTTGGGAGCCCAAATTCCAACCTCTTGCCTCAGTATTTAATGATATTGCAAAACTAAAGGATGAA       CATTTGCATATGCCTGGCATTCCAAAAGAGAAGAAATCTTTTGTTTTTCCACCCCCTTTGATAACAGC       AGTAGCCCAGCCTGGGATTAAAGCAGTCCCACCAAGAATGCCGGCAGTAAACCTGGGGCAGGTGCCTC       CGAAACACCCACGCTCTCCCATCCCCTACCATCTTGGTTCTCTGCCAGAAGGCATGACTCCCAATTTT       TCTCCATCTCTTTCCCTATTGACGATGCAGCCTCCTGCCTTGTCTCCACTGTTGAGAGAAGGAGAATT       ATTAGGAACACACATCAGTGGTACATGCCATGAACTTAAAGCAGAAGATGAAGTTCAAATA TGA   AACC           ACTGGGATGCCAAGTACCTGCTCACCATTGGTCATGAATGAATGAACAAAATGTTTTCAAGCCGGCAA           CTCGAGATTGGGCTCATTTTTATCTAAAAGCAAGTGATGTAATTTAGTTAGAGTTTTTAAAACTTCCC           CATTAAAGTTTCTCCAATTTCAAAAAAAAAAAAAAAAAAAA                                                   NOV50a, CG58567-01   SEQ ID NO: 1066   1063 aa   MW at 117200.4kD               Protein Sequence                     LIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEVMTISEDSLPGVIVTHVSVHDVDLN           SAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNP       PVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTI       STTRFLVEASDGGNPDPRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR       ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSST       AVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLE       ENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPI       SSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTV       QAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLG       TSSPFFSVNRTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLA       VFASSFSISLVVSFLVFLILICILIVMILRHKQKDTINNYEEKKTSSLDADLRVTRDASVLKAFQKTD       DCSNEVVPVDATPEWLSLISIMEKDIVNLYRYSNSSGHCSVEGETAEDKEIQRINEHPYRKCSDSALS       DHESRVPDSGIPRDSDQLSCLSGETDVMVTAETAEASQTFGEGDQGEGCSTTCAQNNVLPQTVQKREA       KESILADVRKESVFISGDQEVRCAALSTQTTSDHDGKDNYHWNYLLSWEPKFQPLASVFNDIAKLKDE       HLHMPGIPKEKKSFVFPPPLITAVAQPGIKAVPPRMPAVNLGQVPPKHPRSPIPYHLGSLPEGMTPNF       SPSLSLLTMQPPALSPLLREGELLGTHISGTCHELKAEDEVQI                                             NOV50b, 220087646   SEQ ID NO: 1067   3075 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GGATCCGAAGTCATGACTATTTCAGAAGATTCTTTGCCTGGTGTAATTGTGACTCATGTGTCAGTTCA           TGATGTGGATTTGAATTCAGCTTTCATATTCAGTTTTGCCAAAGAGAGTAATCCTGGAACCAAGTTTG       CTATTGATCAGAACACTGGAGTGGTGGTGTTGGTGAAAACATTGGATTTTGAAGAAATGACTGAATAT       GAGCTGCTCATCCAAATTTCTGATTCAGTGCACTACACAGAGGGAGCACTTGTAGTCCGTGTGCTGGA       TGTCAATGATAATCCACCAGTGTTTTCTCAAGATTTCTATCAGGTCACAGTTCCTGAATCAATACCTG       TGGGGTATTCAGTGCTGACTCTGTCAGCCACAGACTTAGAAAGCAATGAGAACATTTCTTACAGAATT       CTATCCTCTTCTAAGGAATTCTCCATTGATCCTAAGAATGGCACAATATTTACTATCAGTCCCGTATT       ACTTCTGGATACAATATCAACAACTCAATTTCTTGTGGAAGCCAGTGATGGTGGAAATCCTGACCTGA       GAGCTCTTACTTTAGTGGAGATAGGAATAGAAGATATGAACAATTATGCCCCTGAATTCACAGTCAAA       TCCTATAATCTTAGCCTAAGTGAGGATGCTCTGGTTGGAAGCACGCTTGTTACATTTTCAAACATCGA       CCATGACTGGACCCGTGAAAACACATATGTTGAATATTCCATCATCAGTGGTAATTCACAGAACAATT       TTCATGTGGAAACTAAGTTCTTTCATTCAGAATATCCTTATAAGCAGGTCGGTTATCTTGTGTTGCTT       CACAGTCTGGACAGAGAAGCAAGTGCTAGCCATGAGCTTGTCATTCTGGCATCTGACAGTGGCTGCCC       TCCATTGAGTTCCACAGCTGTCATATCAATACAAGTACTTGATGTCAATGACAATCCCCCAAACTTCA       GCAGCCTGAGCTATCACACCCATGTCAAGGAAAGCACCCCTCTAGGGAGTCACATCACTGTGGTCTCA       GCAAATGACCGTGACACAGGGTCACATGCAGAAATCATCTACAACATCATCTCTGGAAATGAGAAGGG       ACATTTTTACTTAGAAGAAAACACTGGAGTTCTTTATTTGATTAAACCTCTGGATTATGAAAAAATGA       CAAAATTCACCTTAACTGTCCAAGCTTCAGATGCAGAAAAGAAACATTTTTCTTTTGCAGTTGTGTTT       GTCAGTGTCCTGGATGATAACGACCATGCACCTCAGTTTATGTTCTCAAGCTTCAGCTGTATTGTTCC       AGAAAATCTGCCTATTTCCTCTACCATACGCTCTATAAATGCTCTGGATTTTGATGCTGGTCCGTATG       GAGAATTGACCTATTCTATTGTATCACCCTGTTTTCTCACTCATGGAATGTCTTATGATCATGATCTC       TTCCTCATTGACCCTTTGACAGGGGATATTCATGCTAAGCAAATCCTTGACTATGAAAATGGCAATAA       ATACTGCCTCACAGTCCAAGCCAAAGACAAAGGTGATGCAACTGCCTCCTTAGTGGTCTGGGTGGATA       TTGAAGGGATAGATGAATTTGAGCCCATTTTCACTCAAGATCAGTATTTTTTCACCCTCCCAGAAAAG       AATAAAGACAGACAGTTGATTGGCAGAGTGGAAGCCTCAGATGCAGATGCTGGTATTGATGGAGTCAT       TCTTTACTCCCTTGGAACCTCATCTCCTTTCTTTTCAGTAAATAAAACCAATGGAAATATTTATTTGA       TTAGAGCCCTTCCCCTAATAAAAAGTCAACTCAACAAAGAAGACACCTTGGAAATGAAAATAATCGCT       CATAGTCCCAAATCAGATTCCAAGTTTGCATCTTGCACTGTTTTTGTGAATGTGTCTTTCTCCTCTGA       AGGAACACCCTTGGCAGTGTTCGCCAGCAGCTTTTCAATCAGCCTGGTGGTCTCCTTTTTAGTGTTTC       TGATACTCATCTGCATTCTAATTGTAATGATTTTAAGACATAAACAAAAAGACACAATAAACAATTAT       GAGGAGAAGAAAACCTCATCTTTAGATGCGGACTTGAGAGTGACCCGGGATGCCAGTGTGCTCAAAGC       CTTCCAGAAAACTGACGACTGCAGTAACGAGGTGGTCCCTGTGGATGCCACTCCGGAATGGTTGAGTT       TAATAAGTATCATGGAGAAGGATATTGTCAATCTGTACAGACACTCAAACTCCAGTGGCCACTGTTCT       GTGGAAGGAGAAACTGCAGAAGATAAGGAAATCCAGAGGATAAATGAGCATCCCTACAGAAAGTGCTC       AGACTCAGCTCTGAGTGACCACGAGTCCAGGGTGCCAGACTCGGGTATCCCGAGGGACTCAGACCAGC       TCTCCTGCCTATCTGGGGAAACTGATGTGATGGTGACTGCCGAAACAGCAGAAGCCAGCCAAACATTT       GGGGAAGGAGATCAAGGGGAAGGCTGCAGCACCACCTGTGCTCAAAATAATGTGTTACCCCAGACAGT       TCAGAAGAGAGAGGCAAAAGAGAGCATCCTGGCTGATGTTAGAAAAGAGTCTGTCTTTATTTCAGGTG       ATCAGGAAGTAAGGTGTGCAGCTCTTTCAACTCAGACGACCTCTGATCATGATGGAAAGGACAACTAT       CACTGGAATTATCTTCTTAGTTGGGAGCCCAAATTCCAACCTCTTGCCTCAGTATTTAATGATATTGC       AAAACTAAAGGATGAACATTTGCATATGCCTGGCATTCCAAAAGAGAAGAAATCTTTTGTTTTTCCAC       CCCCTTTGATAACAGCAGTAGCCCAGCCTGGGATTAAAGCAGTCCCACCAAGAATGCCGGCAGTAAAC       CTGGGGCAGGTGCCTCCGAAACACCCACGCTCTCCCATCCCCTACCATCTTGGTTCTCTGCCAGAAGG       CATGACTCCCAATTTTTCTCCATCTCTTTCCCTATTGACGATGCAGCCTCCTGCCTTGTCTCCACTGT       TGAGAGAAGGAGAATTATTAGGAACACACATCAGTGGTACATGCCATGAACTTAAAGCAGAAGATGAA       GTTCAAATAGTCGAC                                                 NOV50b, 220087646   SEQ ID NO: 1068   1025 aa   MW at 113052.6kD               Protein Sequence                     GSEVMTISEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEY           ELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRI       LSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVK       SYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLL       HSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVS       ANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVF       VSVLDDNDHAPQFMFSSFSCIVPENLPISSTIRSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDL       FLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEK       NKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIA       HSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISLVVSFLVFLILICILIVMILRHKQKDTINNY       EEKKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPEWLSLISIMEKDIVNLYRHSNSSGHCS       VEGETAEDKEIQRINEHPYRKCSDSALSDHESRVPDSGIPRDSDQLSCLSGETDVMVTAETAEASQTF       GEGDQGEGCSTTCAQNNVLPQTVQKREAKESILADVRKESVFISGDQEVRCAALSTQTTSDHDGKDNY       HWNYLLSWEPKFQPLASVFNDIAKLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPGIKAVPPRMPAVN       LGQVPPKHPRSPIPYHLGSLPEGMTPNFSPSLSLLTMQPPALSPLLREGELLGTHISGTCHELKAEDE       VQIVD                                             NOV50c, 194877960   SEQ ID NO: 1069   3075 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence j                     GGATCCGAAGTCATGACTATTTCAGAAGATTCTTTGCCTGGTGTAATTGTGACTCATGTGTCAGTTCA           TGATGTGGATTTGAATTCAGCTTTCATATTCAGTTTTGCCAAAGAGAGTAATCCTGGAACCAAGTTTG       CTATTGATCAGAACACTGGAGTGGTGGTGTTGGTGAAAACATTGGATTTTGAAGAAATGACTGAATAT       GAGCTGCTCATCCAAATTTCTGATTCAGTGCACTACACAGAGGGAGCACTTGTAGTCCGTGTAATGGA       TGTCAATGATAATCCACCAGTGTTTTCTCAAGATTTCTATCAGGTCACAGTTCCTGAATCAATACCTG       TGGGGTATTCAGTGCTGACTCTGTCAGCCACAGACTTAGAAAGCAATGAGAACATTTCTTACAGAATT       CTATCCTCTTCTAAGGAATTCTCCATTGATCCTAAGAATGGCACAATATTTACTATCAGCCCCGTATT       ACTTCTGGATACAATATCAACAACTCAATTTCTTGTGGAAGCCAGTGATGGTGGAAATCCCGACCTGA       GAGCTCTTACTTTAGTGGAGATAGGAATAGAAGATATGAACAATTATGCCCCTGAATTCACAGTCAAA       TCCTATAATCTTAGCCTAAGTGAGGATGCTCTGGTTGGAAGCACGCTTGTTACATTTTCAAACATCGA       CCATGACTGGACCCGTGAAAACACATATGTTGAATATTCCATCATCAGTGGTAATTCACAGAACAATT       TTCATGTGGAAACTAAGTTCTTTCATTCAGAATATCCTTATAAGCAAGTCGGTTATCTTGTGTTGCTT       CACAGTCTGGACAGAGAAGCAAGTGCTAGCCATGAGCTTGTCATTCTGGCATCTGACAGTGGCTGCCC       TCCATTGAGTTCCACAGCTGTCATATCAATACAAGTACTTGATGTCAATGACAATCCCCCAAACTTCA       GCAGCCTGAGCTATCACACCCATGTCAAGGAAAGCACCCCTCTAGGGAGTCACATCACTGTGGTCTCA       GCAAATGACCGTGACACAGGGTCACATGCAGAAATCATCTACAACATCATCTCTGGAAATGAGAAGGG       ACATTTTTACTTAGAAGAAAACACTGGAGTTCTTTATTTGATTAAACCTCTGGATTATGAAAAAATGA       CAAAATTCACCTTAACTGTCCAAGCTTCAGATGCAGAAAAGAAACATTTTTCTTTTGCAGTTGTGTTT       GTCAGTGTCCTGGATGATAACGACCATGCACCTCAGTTTATGTTCTCAAGCTTCAGCTGTATTGTTCC       AGAAAATCTGCCTATTTCCTCTACCATATGCTCTATAAATGCTCTGGATTTTGATGCTGGTCCGTATG       GAGAATTGACCTATTCTATTGTATCACCCTGTTTTCTCACTCATGGAATGTCTTATGATCATGATCTC       TTCCTCATTGACCCTTTGACAGGGGATATTCATGCTAAGCAAATCCTTGACTATGAAAATGGCAATAA       ATACTGCCTCACAGTCCAAGCCAAAGACAAAGGTGATGCAACTGCCTCCTTAGTGGTCTGGGTGGATA       TTGAAGGGATAGATGAATTTGAGCCCATTTTCACTCAAGATCAGTATTTTTTCACCCTCCCAGAAAAG       AATAAAGACAGACAGTTGATTGGCAGAGTGGAAGCCTCAGATGCAGATGCTGGTATTGATGGAGTCAT       TCTTTACTCCCTTGGAACCTCATCTCCTTTCTTTTCAGTAAATAAAACCAATGGAAATATTTATTTGA       TTAGAGCCCTTCCCCTAATAAAAAGTCAACTCAACAAAGAAGACACCTTGGAAATGAAAATAATCGCT       CATAGTCCCAAATCAGATTCCAAGTTTGCATCTTGCACTGTTTTTGTGAATGTGTCTTTCTCCTCTGA       AGGAACACCCTTGGCAGTGTTCGCCAGCAGCTTTTCAATCAGCCTGGTGGTCTCCTTTTTAGTGTTTC       TGATACTCATCTGCATTCTAATTGTAATGATTTTAAGACATAAACAAAAAGACACAATAAACAATTAT       GAGGAGAAGAAAACCTCATCTTTAGATGCGGACTTGAGAGTGACCCGGGATGCCAGTGTGCTCAkAGC       CTTCCAGAAAACTGACGACTGCAGTAACGAGGTGGTCCCTGTGGATGCCACTCCGGAATGGTTGAGTT       TAATAAGTATCATGGAGAAGGATATTGTCAATCTGTACAGACACTCAAACTCCAGTGGCCACTGTTCT       GTGGAAGGAGAAACTGCAGAAGATAAGGAAATCCAGAGGATAAATGAGCATCCCTACAGAAAGTGCTC       AGACTCAGCTCTGAGTGACCACGAGTCCAGGGTGCCAGACTCGGGTATCCCGAGGGACTCAGACCAGC       TCTCCTGCCTATCTGGGGAAACTGATGTGATGGTGACTGCCGAAACAGCAGAAGCCAGCCAAACATTT       GGGGAAGGAGATCAAGGGGAAGGCTGCAGCACCACCTGTGCTCAAAATAATGTGTTACCCCAGACAGT       TCAGAAGAGAGAGGCAAAAGAGAGCATCCTGGCTGATGTTAGAAAAGAGTCTGTCTTTATTTCAGGTG       ATCAGGAAGTAAGGTGTGCAGCTCTTTCAACTCAGACGACCTCTGATCATGATGGAAAAGACAACTAT       CACTGGAATTATCTTCTTAGTTGGGAGCCCAAATTCCAACCTCTTGCCTCAGTATTTAATGATATTGC       AAAACTAAAGGATGAACATTTGCATATGCCTGGCATTCCAAAAGAGAAGAAATCTTTTGTTTTTCCAC       CCCCTTTGATAACAGCAGTAGCCCAGCCTGGGATTAAAGCAGTCCCACCAAGAATGCCGGCAGTAAAC       CTGGGGCAGGTGCCTCCGAAACACCCACGCTCTCCCATCCCCTACCATCTTGGTTCTCTGCCAGAAGG       CATGACTCCCAATTTTTCTCCATCTCTTTCCCTATTGACGATGCAGCCTCCTGCCTTGTCTCCACTGT       TGAGAGAAGGAGAATTATTAGGAACACACATCAGTGGTACATGCCATGAACTTAAAGCAGAAGATGAA       GTTCAAATAGTCGAC                                                 NOV50c, 194877960   SEQ ID NO: 1070   1025 aa   MW at 112999.6kD               Protein Sequence                     GSEVMTTSEDSLPGVTVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEY           ELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRI       LSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVK       SYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLL       HSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVS       ANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVF       VSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDL       FLIDPLTGDIHAXQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEK       NKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIA       HSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISLVVSFLVFLILICILIVMILRHKQKDTINNY       EEKKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPEWLSLISIMEKDIVNLYRHSNSSGHCS       VEGETAEDKEIQRINEHPYRKCSDSALSDHESRVPDSGIPRDSDQLSCLSGETDVMVTAETAEASQTF       GEGDQGEGCSTTCAQNNVLPQTVQKREAKESILADVRKESVFISGDQEVRCAALSTQTTSDHDGKDNY       HWNYLLSWEPKFQPLASVFNDIAKLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPGIKAVPPRNPAVN       LGQVPPKHPRSPIPYHLGSLPEGMTPNFSPSLSLLTMQPPALSPLLREGELLGTHISGTCHELKAEDE       VQIVD                                             NOV50d, 192589297   SEQ ID NO: 1071   1899 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GGATCCGAAGTCATGACTATTTCAGAAGATTCTTTGCCTGGTGTAATTGTGACTCATGTGTCAGTTCA           TGATGTGGATTTGAATTCAGCTTTCATATTCAGTTTTGCCAAAGAGAGTAATCCTGGAACCAAGTTTG       CTATTGATCAGAACACTGGAGTGGTGGTGTTGGTGAAAACATTGGATTTTGAAGAAATGACTGAATAT       GAGCTGCTCATCCAAATTTCTGATTCAGTGCACTACACAGAGGGAGCACTTGTAGTCCGTGTGCTGGA       TGTCAATGATAATCCACCAGTGTTTTCTCAAGATTTCTATCAGGTCACAGTTCCTGAATCAATACCTG       TGGGGTATTCAGTGCTGACTCTGTCAGCCACAGACTTAGAAAGCAATGAGAACATTTCTTACAGAATT       CTATCCTCTTCTAAGGAATTCTCCATTGATCCTAAGAATGGCACAATATTTACTATCAGTCCCGTATT       ACTTCTGGATACAATATCAACAACTCAATTTCTTGTGGAAGCCAGTGATGGTGGAAATCCTGACCTGA       GAGCTCTTACTTTAGTGGAGATAGGAATAGAAGATATGAACAATTATGCCCCTGAATTCACAGTCAAA       TCCTATAATCTTAGCCTAAGTGAGGATGCTCTGGTTGGAAGCACGCTTGTTACATTTTCAAACATCGA       CCATGACTGGACCCGTGAAAACACATATGTTGAATATTCCATCATCAGTGGTAATTCACAGAACAATT       TTCATGTGGAAACTAAGTTCTTTCATTCAGAATATCCTTATAAGCAAGTCGGTTATCTTGTGTTGCTT       CACAGTCTGGACAGAGAAGCAAGTGCTAGCCATGAGCTTGTCATTCTGGCATCTGACAGTGGCTGCCC       TCCATTGAGTTCCACAGCTGTCATATCAATACAAGTACTTGATGTCAATGACAATCCCCCAAACTTCA       GCAGCCTGAGCTATCACACCCATGTCAAGGAAAGCACCCCTCTAGGGAGTCACATCACTGTGGTCTCA       GCAAATGACCGTGACACAGGGTCACATGCAGAAATCATCTACAACATCATCTCTGGAAATGAGAAGGG       ACATTTTTACTTAGAAGAAAACACTGGAGTTCTTTATTTGATTAAACCTCTGGATTATGAAAAAATGA       CAAAATTCACCTTAACTGTCCAAGCTTCAGATGCAGAAAAGAAACATTTTTCTTTTGCAGTTGTGTTT       GTCAGTGTCCTGGATGATAACGACCATGCACCTCAGTTTATGTTCTCAAGCTTCAGCTGTATTGTTCC       AGAAAATCTGCCTATTTCCTCTACCATATGCTCTATAAATGCTCTGGATTTTGATGCTGGTCCGTATG       GAGAATTGACCTATTCTATTGTATCACCCTGTTTTCTCACTCATGGAATGTCTTATGATCATGATCTC       TTCCTCATTGACCCTTTGACAGGGGATATTCATGCTAAGCAAATCCTTGACTATGAAAATGGCAATAA       ATACTGCCTCACAGTCCAAGCCAAAGACAAAGGTGATGCAACTGCCTCCTTAGTGGTCTGGGTGGATA       TTGAAGGGATAGATGAATTTGAGCCCATTTTCACTCAAGATCAGTATTTTTTCACCCTCCCAGAAAAG       AATAAAGACAGACAGTTGATTGGCAGAGTGGAAGCCTCAGATGCAGATGCTGGTATTGATGGAGTCAT       TCTTTACTCCCTTGGAACCTCATCTCCTTTCTTTTCAGTAAATAAAACCAATGGAAATATTTATTTGA       TTAGAGCCCTTCCCCTAATAAAAAGTCAACTCAACAAAGAAGACACCTTGGAAATGAAAATAATCGCT       CATAGTCCCAAATCAGATTCCAAGTTTGCATCTTGCACTGTTTTTGTGAATGTGTCTGTCGAC                                                 NOV50d, 192589297   SEQ ID NO: 1072   633 aa   MW at 69903.4kD               Protein Sequence                     GSEVMTISEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEY           ELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRI       LSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVK       SYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLL       HSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVS       ANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVF       VSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDL       FLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEK       NKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIA       HSPKSDSKFASCTVFVNVSVD                                             NOV50e, CG58567-02   SEQ ID NO: 1073   2956 bp               DNA Sequence   ORF Start: ATG at 57   ORF Stop: TGA at 2934                       CTATTGATCAGAACACTGGAGTGGTGGTGTTGGTGAAAACATTGGATTTTGAAGAA   ATG ACTGAATAT           GAGCTGCTCATCCAAATTTCTGATTCAGTGCACTACACAGAGGGAGCACTTGTAGTCCGTGTGCTGGA       TGTCAATGATAATCCACCAGTGTTTTCTCAAGATTTCTATCAGGTCACAGTTCCTGAATCAATACCTG       TGGGGTATTCAGTGCTGACTCTGTCAGCCACAGACTTAGAAAGCAATGAGAACATTTCTTACAGAATT       CTATCCTCTTCTAAGGAATTCTCCATTGATCCTAAGAATGGCACAATATTTACTATCAGTCCCGTATT       ACTTCTGGATACAATATCAACAACTCAATTTCTTGTGGAAGCCAGTGATGGTGGAAATCCTGACCTGA       GAGCTCTTACTTTAGTGGAGATAGGAATAGAAGATATGAACAATTATGCCCCTGAATTCACAGTCAAA       TCCTATAATCTTAGCCTAAGTGAGGATGCTCTGGTTGGAAGCACGCTTGTTACATTTTCAAACATCGA       CCATGACTGGACCCGTGAAAACACATATGTTGAATATTCCATCATCAGTGGTAATTCACAGAACAATT       TTCATGTGGAAACTAAGTTCTTTCATTCAGAATATCCTTATAAGCAAGTCGGTTATCTTGTGTTGCTT       CACAGTCTGGACAGAGAAGCAAGTGCTAGCCATGAGCTTGTCATTCTGGCATCTGACAGTGGCTGCCC       TCCATTGAGTTCCACAGCTGTCATATCAATACAAGTACTTGATGTCAATGACAATCCCCCAAACTTCA       GCAGCCTGAGCTATCACACCCATGTCAAGGAAAGCACCCCTCTAGGGAGTCACATCACTGTGGTCTCA       GCAAATGACCGTGACACAGGGTCACATGCAGAAATCATCTACAACATCATCTCTGGAAATGAGAAGGG       ACATTTTTACTTAGAAGAAAACACTGGAGTTCTTTATTTGATTAAACCTCTGGATTATGAAAAAATGA       CAAAATTCACCTTAACTGTCCAAGCTTCAGATGCAGAAAAGAAACATTTTTCTTTTGCAGTTGTGTTT       GTCAGTGTCCTGGATGATAACGACCATGCACCTCAGTTTATGTTCTCAAGCTTCAGCTGTATTGTTCC       AGAAAATCTGCCTATTTCCTCTACCATATGCTCTATAAATGCTCTGGATTTTGATGCTGGTCCGTATG       GAGAATTGACCTATTCTATTGTATCACCCTGTTTTCTCACTCATGGAATGTCTTATGATCATGATCTC       TTCCTCATTGACCCTTTGACAGGGGATATTCATGCTAAGCAAATCCTTGACTATGAAAATGGCAATAA       ATACTGCCTCACAGTCCAAGCCAAAGACAAAGGTGATGCAACTGCCTCCTTAGTGGTCTGGGTGGATA       TTGAAGGGATAGATGAATTTGAGCCCATTTTCACTCAAGATCAGTATTTTTTCACCCTCCCAGAAAAG       AATAAAGACAGACAGTTGATTGGCAGAGTGGAAGCCTCAGATGCAGATGCTGGTATTGATGGAGTCAT       TCTTTACTCCCTTGGAACCTCATCTCCTTCCCTTTCAGTAAATAAAACCAATGGAAATATTTATTTGA       TTAGAGCCCTTCCCCTAATAAAAAGTCAACTCAACAAAGAAGACACCTTGGAAATGAAAATAATCGCT       CATAGTCCCAAATCAGATTCCAAGTTTGCATCTTGCACTGTTTTTGTGAATGTGTCTTTCTCCTCTGA       AGGAACACCCTTGGCAGTGTTCGCCAGCAGCTTTTCAATCAGCCTGGTGGTCTCCTTTTTAGTGTTTC       TGATACTCATCTGCATTCTAATTGTAATGATTTTAAGACATAAACAAAAAGACACAATAAACAATTAT       GAGGAGAAGAAAACCTCATCTTTAGATGCGGACTTGAGAGTGACCCGGGATGCCAGTGTGCTCAAAGC       CTTCCAGAAAACTGACGACTGCAGTAACGAGGTGGTCCCTGTGGATGCCACTCCGGAATGGTTGAGTT       TAATAAGTATCATGGAGAAGGATATTGTCAATCTGTACAGACACTCAAACTCCAGTGGCCACTGTTCT       GTGGAAGGAGAAACTGCAGAAGATAAGGAAATCCAGAGGATAAATGAGCATCCCTACAGAAAGTGCTC       AGACTCAGCTCTGAGTGACCACGAGTCCAGGGTGCCAGACTCGGGTATCCCGAGGGACTCAGACCAGC       TCTCCTGCCTATCTGGGGAAACTGATGTGATGGTGACTGCCGAAACAGCAGAAGCCAGCCAAACATTT       GGGGAAGGAGATCAAGGGGAAGGCTGCAGCACCACCTGTGCTCAAAATAATGTGTTACCCCAGACAGT       TCAGAAGAGAGAGGCAAAAGAGAGCATCCTGGCTGATGTTAGAAAAGAGTCTGTCTTTATTTCAGGTG       ATCAGGAAGTAAGGTGTGCAGCTCTTTCAACTCAGACGACCTCTGATCATGATGGAAAAGACAACTAT       CACTGGAATTATCTTCTTAGTTGGGAGCCCAAATTCCAACCTCTTGCCTCAGTATTTAATGATATTGC       AAAACTAAAGGATGAACATTTGCATATGCCTGGCATTCCAAAAGAGAAGAAATCTTTTGTTTTTCCAC       CCCCTTTGATAACAGCAGTAGCCCAGCCTGGGATTAAAGCAGTCCCACCAAGAATGCCGGCAGTAAAC       CTGGGGCAGGTGCCTCCGAAACACCCACGCTCTCCCATCCCCTACCATCTTGGTTCTCTGCCAGAAGG       CATGACTCCCAATTTTTCTCCATCTCTTTCCCTATTGACGATGCAGCCTCCTGCCTTGTCTCCACTGT       TGAGAGAAGGAGAATTATTAGGAACACACATCAGTGGTACATGCCATGAACTTAAAGCAGAAGATGAA       GTTCAAATA TGA   AACCACTGGGATGCCAAGTA                                                   NOV50e, CG58567-02   SEQ ID NO: 1074   959 aa   MW at 105826.6kD               Protein Sequence                     MTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENI           SYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPE       FTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGY       LVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHI       TVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSF       AVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSY       DHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFT       LPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPSLSVNKTNGNIYLIRALPLIKSQLNKEDTLEM       KIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISLVVSFLVFLILICILIVMILRHKQKDT       INNYEEKKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPEWLSLISIMEKDIVNLYRHSNSS       GHCSVEGETAEDKEIQRINEHPYRKCSDSALSDHESRVPDSGIPRDSDQLSCLSGETDVMVTAETAEA       SQTFGEGDQGEGCSTTCAQNNVLPQTVQKREAKESILADVRKESVFISGDQEVRCAALSTQTTSDHDG       KDNYHWNYLLSWEPKFQPLASVFNDIAKLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPGIKAVPPRM       PAVNLGQVPPKHPRSPIPYHLGSLPEGMTPNFSPSLSLLTMQPPALSPLLREGELLGTHISGTCHELK       AEDEVQI                                             NOV50f, CG58567-03   SEQ ID NO: 1075   3075 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 3070                       GGATCC GAAGTCATGACTATTTCAGAAGATTCTTTGCCTGGTGTAATTGTGACTCATGTGTCAGTTCA           TGATGTGGATTTGAATTCAGCTTTCATATTCAGTTTTGCCAAAGAGAGTAATCCTGGAACCAAGTTTG       CTATTGATCAGAACACTGGAGTGGTGGTGTTGGTGAAAACATTGGATTTTGAAGAAATGACTGAATAT       GAGCTGCTCATCCAAATTTCTGATTCAGTGCACTACACAGAGGGAGCACTTGTAGTCCGTGTGCTGGA       TGTCAATGATAATCCACCAGTGTTTTCTCAAGATTTCTATCAGGTCACAGTTCCTGAATCAATACCTG       TGGGGTATTCAGTGCTGACTCTGTCAGCCACAGACTTAGAAAGCAATGAGAACATTTCTTACAGAATT       CTATCCTCTTCTAAGGAATTCTCCATTGATCCTAAGAATGGCACAATATTTACTATCAGCCCCGTATT       ACTTCTGGATACAATATCAACAACTCAATTTCTTGTGGAAGCCAGTGATGGTGGAAATCCCGACCTGA       GAGCTCTTACTTTAGTGGAGATAGGAATAGAAGATATGAACAATTATGCCCCTGAATTCACAGTCAAA       TCCTATAATCTTAGCCTAAGTGAGGATGCTCTGGTTGGAAGCACGCTTGTTACATTTTCAAACATCGA       CCATGACTGGACCCGTGAAAACACATATGTTGAATATTCCATCATCAGTGGTAATTCACAGAACAATT       TTCATGTGGAAACTAAGTTCTTTCATTCAGAATATCCTTATAAGCAAGTCGGTTATCTTGTGTTGCTT       CACAGTCTGGACAGAGAAGCAAGTGCTAGCCATGAGCTTGTCATTCTGGCATCTGACAGTGGCTGCCC       TCCATTGAGTTCCACAGCTGTCATATCAATACAAGTACTTGATGTCAATGACAATCCCCCAAACTTCA       GCAGCCTGAGCTATCACACCCATGTCAAGGAAAGCACCCCTCTAGGGAGTCACATCACTGTGGTCTCA       GCAAATGACCGTGACACAGGGTCACATGCAGAAATCATCTACAACATCATCTCTGGAAATGAGAAGGG       ACATTTTTACTTAGAAGAAAACACTGGAGTTCTTTATTTGATTAAACCTCTGGATTATGAAAAAATGA       CAAAATTCACCTTAACTGTCCAAGCTTCAGATGCAGAAAAGAAACATTTTTCTTTTGCAGTTGTGTTT       GTCAGTGTCCTGGATGATAACGACCATGCACCTCAGTTTATGTTCTCAAGCTTCAGCTGTATTGTTCC       AGAAAATCTGCCTATTTCCTCTACCATATGCTCTATAAATGCTCTGGATTTTGATGCTGGTCCGTATG       GAGAATTGACCTATTCTATTGTATCACCCTGTTTTCTCACTCATGGAATGTCTTATGATCATGATCTC       TTCCTCATTGACCCTTTGACAGGGGATATTCATGCTAAGCAAATCCTTGACTATGAAAATGGCAATAA       ATACTGCCTCACAGTCCAAGCCAAAGACAAAGGTGATGCAACTGCCTCCTTAGTGGTCTGGGTGGATA       TTGAAGGGATAGATGAATTTGAGCCCATTTTCACTCAAGATCAGTATTTTTTCACCCTCCCAGAAAAG       AATAAAGACAGACAGTTGATTGGCAGAGTGGAAGCCTCAGATGCAGATGCTGGTATTGATGGAGTCAT       TCTTTACTCCCTTGGAACCTCATCTCCTTTCTTTTCAGTAAATAAAACCAATGGAAATATTTATTTGA       TTAGAGCCCTTCCCCTAATAAAAAGTCAACTCAACAAAGAAGACACCTTGGAAATGAAAATAATCGCT       CATAGTCCCAAATCAGATTCCAAGTTTGCATCTTGCACTGTTTTTGTGAATGTGTCTTTCTCCTCTGA       AGGAACACCCTTGGCAGTGTTCGCCAGCAGCTTTTCAATCAGCCTGGTGGTCTCCTTTTTAGTGTTTC       TGATACTCATCTGCATTCTAATTGTAATGATTTTAAGACATAAACAAAAAGACACAATAAACAATTAT       GAGGAGAAGAAAACCTCATCTTTAGATGCGGACTTGAGAGTGACCCGGGATGCCAGTGTGCTCAAAGC       CTTCCAGAAAACTGACGACTGCAGTAACGAGGTGGTCCCTGTGGATGCCACTCCGGAATGGTTGAGTT       TAATAAGTATCATGGAGAAGGATATTGTCAATCTGTACAGACACTCAAACTCCAGTGGCCACTGTTCT       GTGGAAGGAGAAACTGCAGAAGATAAGGAAATCCAGAGGATAAATGAGCATCCCTACAGAAAGTGCTC       AGACTCAGCTCTGAGTGACCACGAGTCCAGGGTGCCAGACTCGGGTATCCCGAGGGACTCAGACCAGC       TCTCCTGCCTATCTGGGGAAACTGATGTGATGGTGACTGCCGAAACAGCAGAAGCCAGCCAAACATTT       GGGGAAGGAGATCAAGGGGAAGGCTGCAGCACCACCTGTGCTCAAAATAATGTGTTACCCCAGACAGT       TCAGAAGAGAGAGGCAAAAGAGAGCATCCTGGCTGATGTTAGAAAAGAGTCTGTCTTTATTTCAGGTG       ATCAGGAAGTAAGGTGTGCAGCTCTTTCAACTCAGACGACCTCTGATCATGATGGAAAAGACAACTAT       CACTGGAATTATCTTCTTAGTTGGGAGCCCAAATTCCAACCTCTTGCCTCAGTATTTAATGATATTGC       AAAACTAAAGGATGAACATTTGCATATGCCTGGCATTCCAAAAGAGAAGAAATCTTTTGTTTTTCCAC       CCCCTTTGATAACAGCAGTAGCCCAGCCTGGGATTAAAGCAGTCCCACCAAGAATGCCGGCAGTAAAC       CTGGGGCAGGTGCCTCCGAAACACCCACGCTCTCCCATCCCCTACCATCTTGGTTCTCTGCCAGAAGG       CATGACTCCCAATTTTTCTCCATCTCTTTCCCTATTGACGATGCAGCCTCCTGCCTTGTCTCCACTGT       TGAGAGAAGGAGAATTATTAGGAACACACATCAGTGGTACATGCCATGAACTTAAAGCAGAAGATGAA       GTTCAAATAGTCGAC                                                 NOV50f, CG58567-03   SEQ ID NO: 1076   1021 aa   MW at 112641.2kD               Protein Sequence                     EVMTISEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYEL           LIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILS       SSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSY       NLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHS       LDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSAN       DRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVS       VLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFL       IDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNK       DRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHS       PKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISLVVSFLVFLILICILIVMILRHKQKDTINNYEE       KKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPEWLSLISIMEKDIVNLYRHSNSSGHCSVE       GETAEDKEIQRINEHPYRKCSDSALSDHESRVPDSGIPRDSDQLSCLSGETDVMVTAETAEASQTFGE       GDQGEGCSTTCAQNNVLPQTVQKREAKESILADVRKESVFISGDQEVRCAALSTQTTSDHDGKDNYHW       NYLLSWEPKFQPLASVFNDIAKLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPGIKAVPPRMPAVNLG       QVPPKHPRSPIPYHLGSLPEGMTPNFSPSLSLLTMQPPALSPLLREGELLGTHISGTCHELKAEDEVQ       I                                             NOV50g, CG58567-04   SEQ ID NO: 1077   1899 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GGATCCGAAGTCATGACTATTTCAGAAGATTCTTTGCCTGGTGTAATTGTGACTCATGTGTCAGTTCA           TGATGTGGATTTGAATTCAGCTTTCATATTCAGTTTTGCCAAAGAGAGTAATCCTGGAACCAAGTTTG       CTATTGATCAGAACACTGGAGTGGTGGTGTTGGTGAAAACATTGGATTTTGAAGAAATGACTGAATAT       GAGCTGCTCATCCAAATTTCTGATTCAGTGCACTACACAGAGGGAGCACTTGTAGTCCGTGTGCTGGA       TGTCAATGATAATCCACCAGTGTTTTCTCAAGATTTCTATCAGGTCACAGTTCCTGAATCAATACCTG       TGGGGTATTCAGTGCTGACTCTGTCAGCCACAGACTTAGAAAGCAATGAGAACATTTCTTACAGAATT       CTATCCTCTTCTAAGGAATTCTCCATTGATCCTAAGAATGGCACAATATTTACTATCAGTCCCGTATT       ACTTCTGGATACAATATCAACAACTCAATTTCTTGTGGAAGCCAGTGATGGTGGAAATCCTGACCTGA       GAGCTCTTACTTTAGTGGAGATAGGAATAGAAGATATGAACAATTATGCCCCTGAATTCACAGTCAAA       TCCTATAATCTTAGCCTAAGTGAGGATGCTCTGGTTGGAAGCACGCTTGTTACATTTTCAAACATCGA       CCATGACTGGACCCGTGAAAACACATATGTTGAATATTCCATCATCAGTGGTAATTCACAGAACAATT       TTCATGTGGAAACTAAGTTCTTTCATTCAGAATATCCTTATAAGCAAGTCGGTTATCTTGTGTTGCTT       CACAGTCTGGACAGAGAAGCAAGTGCTAGCCATGAGCTTGTCATTCTGGCATCTGACAGTGGCTGCCC       TCCATTGAGTTCCACAGCTGTCATATCAATACAAGTACTTGATGTCAATGACAATCCCCCAAACTTCA       GCAGCCTGAGCTATCACACCCATGTCAAGGAAAGCACCCCTCTAGGGAGTCACATCACTGTGGTCTCA       GCAAATGACCGTGACACAGGGTCACATGCAGAAATCATCTACAACATCATCTCTGGAAATGAGAAGGG       ACATTTTTACTTAGAAGAAAACACTGGAGTTCTTTATTTGATTAAACCTCTGGATTATGAAAAAATGA       CAAAATTCACCTTAACTGTCCAAGCTTCAGATGCAGAAAAGAAACATTTTTCTTTTGCAGTTGTGTTT       GTCAGTGTCCTGGATGATAACGACCATGCACCTCAGTTTATGTTCTCAAGCTTCAGCTGTATTGTTCC       AGAAAATCTGCCTATTTCCTCTACCATATGCTCTATAAATGCTCTGGATTTTGATGCTGGTCCGTATG       GAGAATTGACCTATTCTATTGTATCACCCTGTTTTCTCACTCATGGAATGTCTTATGATCATGATCTC       TTCCTCATTGACCCTTTGACAGGGGATATTCATGCTAAGCAAATCCTTGACTATGAAAATGGCAATAA       ATACTGCCTCACAGTCCAAGCCAAAGACAAAGGTGATGCAACTGCCTCCTTAGTGGTCTGGGTGGATA       TTGAAGGGATAGATGAATTTGAGCCCATTTTCACTCAAGATCAGTATTTTTTCACCCTCCCAGAAAAG       AATAAAGACAGACAGTTGATTGGCAGAGTGGAAGCCTCAGATGCAGATGCTGGTATTGATGGAGTCAT       TCTTTACTCCCTTGGAACCTCATCTCCTTTCTTTTCAGTAAATAAAACCAATGGAAATATTTATTTGA       TTAGAGCCCTTCCCCTAATAAAAAGTCAACTCAACAAAGAAGACACCTTGGAAATGAAAATAATCGCT       CATAGTCCCAAATCAGATTCCAAGTTTGCATCTTGCACTGTTTTTGTGAATGTGTCTGTCGAC                                                 NOV50g, CG58567-04   SEQ ID NO: 1078   633 aa   MW at 69903.4kD               Protein Sequence                     GSEVMTISEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEY           ELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRI       LSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLPALTLVEIGIEDMNNYAPEFTVK       SYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLL       HSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVS       ANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVF       VSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDL       FLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEK       NKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIA       HSPKSDSKFASCTVFVNVSVD                                             NOV50h, CG58567-05   SEQ ID NO: 1079   9193 bp               DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 9010                       ATG GAGAAATGTGGGCTTAAAGAGGAAGGCAGTTACGCGGACATAGATCCAGTTGCCCACGATCCGGA           CGCCGGACTGTTCAGCACTCAGGGCTACACCCTGGTGCAACCGTCCGACCTGCCCAAGGACCCCGCAG       GCCCGTTCTTCCAGTTGCGCTACCGGACTCCGGGGCCACTACCGTCACCGCTTTTGCCAGGCTCCTCG       TCACCCCTGGAGCCTCTAGATCTGGTGCTGCTGCGGCGCTTGGACCGAGAGGAGGCGGCGGCGCACCG       GCTGCAGATCGAGGCATGGGACGGCGGCCGACCCCGGCGCACCGGCCTCCTGAGCGTGGAGCTGCGCG       TGCTGGATGAGAACGACAACCCGCCGGTCTTTGAGCAGGACGAGTACCGCGCCGCGGTGCGCGAGGAC       GCCCAGCCGGGCGCCGAGGTCTGTCGCGTGCGCGCCACCGACCGCGACCTGGGGCCCAATGGCTTCGT       GCGCTACAGCGTCCGCGCCCGGCAAGTGCCTGGGGCGGGTAGCGGCGGCGGGGCACTGGGCGACGCGG       CCTACTTCGCGGTGGAGGAGCTGAGCGGCGTGGTGCGAGTGTGGAGACCTCTGGACCGCGAGGCACAG       GCCTGGCACCAGTTGGTGGTGGAGGCCCGCGATGGAGGCGCCGAGCCTGAGGTTGCCACGGTGCGCGT       GTCCATCGCCGTGCTGGACGTGAATGACAACCGGCCAGCAATTCACGTGCTCTTTCTCACAGAGGGAG       GCGTCGCCCGTGTCTCTGAAGGCGCCCGACCGGGCGACTACGTGGCTCGCGTCTCGGTGTCTGACGCG       GACGGGGTAATAGGCAAAATTACAGCTATTGACATGGACTCTGGAAAGAATGGACAGCTATTATATTT       CCTTTTGTCTGATGGAAAATTCTTCAAGATGAATCCTAATACAGGAGAGTTAATCAATTGGGTGGCAC       TGGATCGTGAGCACCGGGGGCACCATGAGATGACTGTGCTAGTGACAGACCGCGGCTCCCCACCACGA       AACGCCACCATGGCGGTTTACGTCTCAGTTACTGACATCAATGATAACAGGCCCTTCTTCCCCCAGTG       TCTCCCTGGAAAGGAGTTACACGTGAAGGTTCTGGAAGGTCAACCAGTAAATATGTTGGTTACAACTG       TGTTTGCAAAGGATCCTGATGAAGGAAATAATGCAGAAGTTACATACTCAGTATCTTCAGAAGATAGT       TCTGATCACTTTAAGATTGACGCCAACAATGGTGAAATAAGAACAACCACAATACTTTCGTATGATTA       TAGACCTTCCTACAGAATGAGTGTCATTGCCACTGACCAGGGAGTGCCTCCTCTTCAAGGACAGGCAG       TTGTTAATATTCAGGAACTTGATTATGAGACGACATCTCATTATCTTTTCAGAGTGATTACTACAGAC       CATAGCAAAAACCTTTCCCTGAGTAGCACAGTCTTCCTTAGTATCGATGTGGAAGATCAGAATGACCA       TTCCCCATCTTTCCAGGATGAGCTCATTGTGATCAGTGTAGAGGAGAATGTTCCCATAGGAACCCTGG       TGTATGTCTTCAATGCCAAAGATGATGACGGCAGTTTTTTGAACAGTAGAATACAATACTACATTGAA       TCCCACAACCCTGGCACGAATCCATTTCTCATCCACCCCTCATTTGGCACACTAGTCACTGTGTCCCG       TCTTGACAGAGAAAGCATTCCAACTGTCATCCTGACAGTAACAGCATCTGATCAGGCTGTGAATGTGA       CAGACCGGCGACTGAGATCACTGACAGCACAAATAGTGATTTTGGATGTAAATGACCACAACCCCACT       TTTATTTCTTTCCCCAATGCCCATGTCAAAGAGGATGTCACAGTGGGCTCCTTGGTCCACCACATAAC       TGCTCACGATCCAGACGAAGGAAGGAATGGAAAAGTAACATACAGCATCCTCTCAGGAAATGAAAACA       TGACGTTTATGCTAGATGAGTCATCAGGCTTACTAACCACAACCTGTCCTTTGGATTATGAAATGAAA       ACTCAGCATATTCTGACTGTTCTGGCACTGGATGATGGCACACCAGCACTTTCTTCATCCCAGACTTT       GACAGTTACTGTTCTTGATGTAAATGATGAAGCTCCAGTATTTAAGCAGCACCTGTATGAAGCCTCAG       TGAAAGAAAACCAAAATCCAGGGGAGTTTGTTACCAGGGTTGAAGCTCTGGACAGAGATTCAGTGTTC       CTTAATACTAGAGAGCTTAACATGTGTTTTCTAGCATTCTACGATGCAGTTTTTAAAAATGGTGGGCT       AAGTGCCCAAGCCTTTGTTCGTGTGGACCTGGAGGACGTGAATGATAATCATCCTGTGTTTAACCCAT       CAACCTATGTGACGAGCATCAGTGATGAGACCCAGCCAGGCACCGAGATCATCAATGTTCTTGCCACT       GACCAGGACTCTGGGATATATGGGACAGTGGCTTATGAGCTTATTCCAGGAAACGTGTCGTCCCTTTT       TACCATTGACTCCACCACAGGAATTATTTACTTAACATTACCTCTTAGTCATTTGGAATCTACCACAC       TTTCGTTGATGGTCTCTGCTCAAGACGGTGGTGGGCTCACAGCTGTCATTAATGCCGATGTCACCATA       CACATTTTCCAGACAACTCTGGCACCTGCTGAGTTTGAAAGGCCTAAGTACACTTTCTTAGTTTATGA       AGATGTGCCTGAAGATAGTCCCATTGGAACAGTGAAAGCAAGAGAGCCCTTGAATCCACCTAGGAGCT       CTGTAATACACCTGCAAGTTAGAGTTTTGGATGCCAATGACCACAGTCCTTCTTTTCCCACACTTTAT       TACCAGTCCTCTGTGAGAGAAGATGCTGAAGTGGGAACAGTGGTTCTTGTGCTTTCAGCTGTGGACAA       GGATGAAGGCCTGAATGGGCAAACTGAGTATTTTCTGACTGATGAGGCTTGTGGTGCATTCACCATTG       ATCCTATGTCAGGCACATTGAAAACCAGCAACACCCTCGACCGTGAAGCCAGATCTCAGCATACATTT       AGTGCTGTGGCCAGAGACTGTAGCATCCAGGGTTCACGAAGCACCACTGTAATTATAAAAGTATATGT       CACTGATGTTAATGACAATGATCCAGTTTTGGAACAGAACCCTTTTGATGTGTTTCTTTCCCCCGAGT       CGCCTACAAACCAGACAACTGTCATTGTGAGAGCTGATGACCTGGACTTGGGGCCCAATGGAACTGTG       GACTCCGATGACTCCCCGCTGCTGGACGACTTCCACGTGCACCCGGACACCGGCATCATCCGCACTGC       GCGGCGCCTGGACCGCGAGCGGCGGGACCACTACAGCTTCGTCGCCGCCACGCTGCTGGGCGCTGTGG       TGCAGGTGGAGATTCGCGTCAACGACGTGAATGACCACTCGCCCCGCTTTCCCCTCGACTCCCTGCAA       CTCGACGTCTCCGAGCTCAGCCCGCCAGGGACCGCCTTCCGCCTGCCAGTTGCCCACGATCCGGACGC       CGGACTGTTCAGCACTCAGGGCTACACCCTGGTGCAACCGTCCGACCTGCCCAAGGACCCCGCAGGCC       CGTTCTTCCAGTTGCGCTACCGGACTCCGGGGCCACTACCGTCACCGCTTTTGCCAGGCTCCTCGTCA       CCCCTGGAGCCTCTAGATCTGGTGCTGCTGCGGCGCTTGGACCGAGAGGAGGCGGCGGCGCACCGGCT       GCAGATCGAGGCATGGGACGGCGGCCGACCCCGGCGCACCGGCCTCCTGAGCGTGGAGCTGCGCGTGC       TGGATGAGAACGACAACCCGCCGGTCTTTGAGCAGGACGAGTCCCGCGCCGCGGTGCGAGAGCACGCC       CAGCCGGGCGCCGAGGTCTGTCGCGTGCGCGCCACCGCCCGCGACGTGGGGCCCAATGGCTTCGTGCG       CTACAGCGTCCGCGCCCGGCAAGTGCCTGGGGCGGGTAGCGGCGGCGGGGCACTGGGCGACGCGGCCT       ACTTCGCGTTGGTGGTGGAGGCCCGCGATGGAGGCGCCGAGCATGAGGTTGCCGCGGTGCGTGTGTCC       ATCGCCGTGCTGGACGTGAATGACAACCGGCCAGCAATTCACGTGCTCTTTCTCACAGAGGGAGGTGT       CGCCCGTGTCTCTGAAGGCGCCCGCCCGGGCGACTACGTGGCTCGCGTCTCGGTGTCTGACGCGGGCG       GTGACTGGGAGAAGGAAGATGAGGCCACAGGGGAGCTTGGTGTGACAGCCTCTGATGCAGATTCAGGA       CTCTATGGCTTTATTGAATATTCTCTTTATGATGGATTCCTGAGCTATGAAGCACCTCAGGCATTCCG       GATCGACCCTCATGATGGGCAAATCTGTGTTTCTCAAGATATCGACAGGGAAAGGGATCCAGCTACCT       ATGATCTCCTGGTGGAAGCTAAGGATGGGTTTGAAATCATGCCAGGTGCTTCATTTGAATTATTCGAG       ATAAATTCTGACACTGGAGAGGTAGTGACAACCACCATACTTGACAGAGAAATTCAAGAAGTCTTCAC       CCTTCGAGTACTAGTACGAGATGGGGGATTCCCTTCATTGTCCAGCACCACAACAATCCTCTGCACTG       TTGAAGATGAAAACGATCACGCACCAGAGTTTATTGTTTCCAGTTATGACATTGAGGTTCTGGAAAAC       CAGGAACCAGAGGTTGTCTATACGGTTTTAGCCTCTGATATGGATGCTGGCAATAACAGAGCTGTTGA       ATATCACATAATTGACTCCTCAGAACCAATCTTTTACAGGATTTCTTCTGGTGATCTCGGCGGAAAGT       TCTCCATTCACCCGCGGCTGGGCACTATTCGCACCCGGAAGCCCCTGGATCACGAGACGCAGCCCGTG       GTTGTGCTCACGGTGCAGGCGCAGCTCGGCAGCGCCCCAGCCTGCAGCAGCACCGAGGTCAACATAAC       AGTCATGGATGTCAATGACAACCACCCAGCGTTCCTCAGGACCTCGGATGAGATTAGAATATCCCAGA       CCACGCCCCCTGGCACAGCCTTGTACCTCGCACGTGCGGAAGACAGAGACAGTGGGCGGAACGGACTC       ATCCGGTACTCCATCGCCAGCCCGCAGCCAGGCGTCTTTGCCATCGACAGAGCCCTGGGGGTGCTGTT       CCTCAACGGCAGCCTGGGCGCGGGCGAGCAGCGGGAGCTCACGCTGACTCTCAGGGCCGAGGACCAAG       GCGTGCATCCTCAGGCAGCCCTGCTGGTGCTGACAGTCGTTATCGAGAAACGCGAACACAGCCCATCC       TGGACTTTCGAACATTTGGTCTATCAAGTGGAAGTCAGTACTTCTATTGTGACTGTTAAAGCTTTTGC       TCCTGACTCAATTCAGGACAGCATGAAATATTCAATTTTTAGTGGAAATGAAGATGGAGTTCTTTCCC       TGTGCTCTAAGTCAGGTGTGGTGAACTGCCTTGCTTCTCTCAGTCACACAGACTTTCTCTCCCTGAAA       TTTGAATCTTCGGTGAAGGGACACCAAGACAGAGACAAATTACAGCCAATTCATCTTGATGACAACAA       CTCAAAGAAGCTGTGCTTTACATTCCCTAGAGCCACTCAGGCTCTTGTATTCACTGGGCACTGTCTTT       CTGATACATCTCTCCCCGGTTGGGTTTTTGCTACCGACTTGGACAGTGGTTTGAACGGCCTGATTGAG       TATTCTATTCTGTCTGGCAACCAAGAAGAAGCATTCCAGATTGATGCACTGAGTGGTGTGATAACAAC       AAAAGCGATTCTAGATTACGAGCTCACCAGCTCCTACAGCTTGATTGTCCAAGCCACAGATAAAGGGA       TGCCCAGGCTTTCTAATACGACTGTAATCAAGGTACAGGTGACTGATATAAATGACAATGCCCCAGCT       TTTCTCCCCTCTGAAGCAGTGGAAATTACAGAAGTCATGACTATTTCAGAAGATTCTTTGCCTGGTGT       AATTGTGACTCATGTGTCAGTTCATGATGTGGATTTGAATTCAGCTTTCATATTCAGTTTTGCCAAAG       AGAGTAATCCTGGAACCAAGTTTGCTATTGATCAGAACACTGGAGTGGTGGTGTTGGTGAAAACATTG       GATTTTGAAGAAATGACTGAATATGAGCTGCTCATCCAAATTTCTGATTCAGTGCACTACACAGAGGG       AGCACTTGTAGTCCGTGTGCTGGATGTCAATGATAATCCACCAGTGTTTTCTCAAGATTTCTATCAGG       TCACAGTTCCTGAATCAATACCTGTGGGGTATTCAGTGCTGACTCTGTCAGCCACAGACTTAGAAAGC       AATGAGAACATTTCTTACAGAATTCTATCCTCTTCTAAGGAATTCTCCATTGATCCTAAGAATGGCAC       AATATTTACTATCAGTCCCGTATTACTTCTGGATACAATATCAACAACTCGATTTCTTGTGGAAGCCA       GTGATGGTGGAAATCCTGACCCGAGAGCTCTTACTTTAGTGGAGATAGGAATAGAAGATATGAACAAT       TATGCCCCTGAATTCACAGTCAAATCCTATAATCTTAGCCTAAGTGAGGATGCTCTGGTTGGAAGCAC       GCTTGTTACATTTTCAAACATCGACCATGACTGGACCCGTGAAAACACATATGTTGAATATTCCATCA       TCAGTGGTAATTCACAGAACAATTTTCATGTGGAAACTAAGTTCTTTCATTCAGAATATCCTTATAAG       CAAGTCGGTTATCTTGTGTTGCTTCACAGTCTGGACAGAGAAGCAAGTGCTAGCCATGAGCTTGTCAT       TCTGGCATCTGACAGTGGCTGCCCTCCATTGAGTTCCACAGCTGTCATATCAATACAAGTACTTGATG       TCAATGACAATCCCCCAAACTTCAGCAGCCTGAGCTATCACACCCATGTCAAGGAAAGCACCCCTCTA       GGGAGTCACATCACTGTGGTCTCAGCAAATGACCGTGACACAGGGTCACATGCAGAAATCATCTACAA       CATCATCTCTGGAAATGAGAAGGGACATTTTTACTTAGAAGAAAACACTGGAGTTCTTTATTTGATTA       AACCTCTGGATTATGAAAAAATGACAAAATTCACCTTAACTGTCCAAGCTTCAGATGCAGAAAAGAAA       CATTTTTCTTTTGCAGTTGTGTTTGTCAGTGTCCTGGATGATAACGACCATGCACCTCAGTTTATGTT       CTCAAGCTTCAGCTGTATTGTTCCAGAAAATCTGCCTATTTCCTCTACCATATGCTCTATAAATGCTC       TGGATTTTGATGCTGGTCCGTATGGAGAATTGACCTATTCTATTGTATCACCCTGTTTTCTCACTCAT       GGAATGTCTTATGATCATGATCTCTTCCTCATTGACCCTTTGACAGGGGATATTCATGCTAAGCAAAT       CCTTGACTATGAAAATGGCAATAAATACTGCCTCACAGTCCAAGCCAAAGACAAAGGTGATGCAACTG       CCTCCTTAGTGGTCTGGGTGGATATTGAAGGGATAGATGAATTTGAGCCCATTTTCACTCAAGATCAG       TATTTTTTCACCCTCCCAGAAAAGAATAAAGACAGACAGTTGATTGGCAGAGTGGAAGCCTCAGATGC       AGATGCTGGTATTGATGGAGTCATTCTTTACTCCCTTGGAACCTCATCTCCTTTCTTTTCAGTAAATA       GAACCAATGGAAATATTTATTTGATTAGAGCCCTTCCCCTAATAAAAAGTCAACTCAACAAAGAAGAC       ACCTTGGAAATGAAAATAATCGCTCATAGTCCCAAATCAGATTCCAAGTTTGCATCTTGCACTGTTTT       TGTGAATGTGTCTTTCTCCTCTGAAGGAACACCCTTGGCAGTGTTCGCCAGCAGCTTTTCAATCAGCC       TGGTGGTCTCCTTTTTAGTGTTTCTGATACTCATCTGCATTCTAATTGTAATGATTTTAAGACATAAA       CAAAAAGACACAATAAACAATTATGAGGAGAAGAAAACCTCATCTTTAGATGCGGACTTGAGAGTGAC       CCGGGATGCCAGTGTGCTCAAAGCCTTCCAGAAAACTGACGACTGCAGTAACGAGGTGGTCCCTGTGG       ATGCCACTCCGGAATGGTTGAGTTTAATAAGTATCATGGAGAAGGATATTGTCAATCTGTACAGATAC       TCAAACTCCAGTGGCCACTGTTCTGTGGAAGGAGAAACTGCAGAAGATAAGGAAATCCAGAGGATAAA       TGAGCATCCCTACAGAAAGTGCTCAGACTCAGCTCTGAGTGACCACGAGTCCAGGGTGCCAGACTCGG       GTATCCCGAGGGACTCAGACCAGCTCTCCTGCCTATCTGGGGAAACTGATGTGATGGTGACTGCCGAA       ACAGCAGAAGCCAGCCAAACATTTGGGGAAGGAGATCAAGGGGAAGGCTGCAGCACCACCTGTGCTCA       AAATAATGTGTTACCCCAGACAGTTCAGAAGAGAGAGGCAAAAGAGAGCATCCTGGCTGACGTTAGAA       AAGAGTCTGTCTTTATTTCAGGTGATCAGGAAGTAAGGTGTGCAGCTCTTTCAACTCAGACGACCTCT       GATCATGATGGAAAAGACAACTATCACTGGAATTATCTTCTTAGTTGGGAGCCCAAATTCCAACCTCT       TGCCTCAGTATTTAATGATATTGCAAAACTAAAGGATGAACATTTGCATATGCCTGGCATTCCAAAAG       AGAAGAAATCTTTTGTTTTTCCACCCCCTTTGATAACAGCAGTAGCCCAGCCTGGGATTAAAGCAGTC       CCACCAAGAATGCCGGCAGTAAACCTGGGGCAGGTGCCTCCGAAACACCCACGCTCTCCCATCCCCTA       CCATCTTGGTTCTCTGCCAGAAGGCATGACTCCCAATTTTTCTCCATCTCTTTCCCTATTGACGATGC       AGCCTCCTGCCTTGTCTCCACTGTTGAGAGAAGGAGAATTATTAGGAACACACATCAGTGGTACATGC       CATGAACTTAAAGCAGAAGATGAAGTTCAAATA TGA   AACCACTGGGATGCCAAGTACCTGCTCACCAT           TGGTCATGAATGAATGAACAAAATGTTTTCAAGCCGGCAACTCGAGATTGGGCTCATTTTTATCTAAA           AGCAAGTGATGTAATTTAGTTAGAGTTTTTAAAACTTCCCCATTAAAGTTTCTCCAATTTCAAAAAAA           AAAAAAAAAAA                                                   NOV50h, CG58567-05   SEQ ID NO: 1080   3003 aa   MW at 329184.0kD               Protein Sequence                     MEKCGLKEEGSYADIDPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS           SPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVRED       AQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQ       AWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDA       DGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPR       NATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDS       SDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQELDYETTSHYLFRVITTD       HSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIE       SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPT       FISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMK       TQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSVF       LNTRELNMCFLAFYDAVFKNGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLAT       DQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTI       HIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNPPRSSVIHLQVRVLDANDHSPSFPTLY       YQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEACGAFTIDPMSGTLKTSNTLDREARSQHTF       SAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTV       DSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVNDVNDHSPRFPLDSLQ       LDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS       PLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDESRAAVREHA       QPGAEVCRVRATARDVGPNGFVRYSVRARQVPGAGSGGGALGDAAYFALVVEARDGGAEHEVAAVRVS       IAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDAGGDWEKEDEATGELGVTASDADSG       LYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGFEIMPGASFELFE       INSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLEN       QEPEVVYTVLASDMDAGNNRAVEYHIIDSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV       VVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL       IRYSIASPQPGVFAIDPALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPS       WTFEHLVYQVEVSTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGVVNCLASLSHTDFLSLK       FESSVKGHQDRDKLQPIHLDDNNSKKLCFTFPRATQALVFTGHCLSDTSLPGWVFATDLDSGLNGLIE       YSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPA       FLPSEAVEITEVMTISEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTL       DFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES       NENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTRFLVEASDGGNPDPRALTLVEIGIEDMNN       YAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYK       QVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPL       GSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKK       HFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTH       GMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQ       YFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNRTNGNIYLIRALPLIKSQLNKED       TLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISLVVSFLVFLILICILIVMILRHK       QKDTINNYEEKKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPEWLSLISIMEKDIVNLYRY       SNSSGHCSVEGETAEDKEIQRINEHPYRKCSDSALSDHESRVPDSGIPRDSDQLSCLSGETDVMVTAE       TAEASQTFGEGDQGEGCSTTCAQNNVLPQTVQKREAKESILADVRKESVFISGDQEVRCAALSTQTTS       DHDGKDNYHWNYLLSWEPKFQPLASVFNDIAKLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPGIKAV       PPRMPAVNLGQVPPKHPRSPIPYHLGSLPEGMTPNFSPSLSLLTMQPPALSPLLREGELLGTHISGTC       HELKAEDEVQI                                             NOV50i, CG58567-06   SEQ ID NO: 1081   10267 bp               DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 10084                       ATG GAGAAATGTGGGCTTAAAGAGGAAGGCAGTTACGCGGACATAGATCCAGTTGCCCACGATCCGGA           CGCCGGACTGTTCAGCACTCAGGGCTACACCCTGGTGCAACCGTCCGACCTGCCCAAGGACCCCGCAG       GCCCGTTCTTCCAGTTGCGCTACCGGACTCCGGGGCCACTACCGTCACCGCTTTTGCCAGGCTCCTCG       TCACCCCTGGAGCCTCTAGATCTGGTGCTGCTGCGGCGCTTGGACCGAGAGGAGGCGGCGGCGCACCG       GCTGCAGATCGAGGCATGGGACGGCGGCCGACCCCGGCGCACCGGCCTCCTGAGCGTGGAGCTGCGCG       TGCTGGATGAGAACGACAACCCGCCGGTCTTTGAGCAGGACGAGTACCGCGCCGCGGTGCGCGAGGAC       GCCCAGCCGGGCGCCGAGGTCTGTCGCGTGCGCGCCACCGACCGCGACCTGGGGCCCAATGGCTTCGT       GCGCTACAGCGTCCGCGCCCGGCAAGTGCCTGGGGCGGGTAGCGGCGGCGGGGCACTGGGCGACGCGG       CCTACTTCGCGGTGGAGGAGCTGAGCGGCGTGGTGCGAGTGTGGAGACCTCTGGACCGCGAGGCACAG       GCCTGGCACCAGTTGGTGGTGGAGGCCCGCGATGGAGGCGCCGAGCCTGAGGTTGCCACGGTGCGCGT       GTCCATCGCCGTGCTGGACGTGAATGACAACCGGCCAGCAATTCACGTGCTCTTTCTCACAGAGGGAG       GCGTCGCCCGTGTCTCTGAAGGCGCCCGACCGGGCGACTACGTGGCTCGCGTCTCGGTGTCTGACGCG       GACGGTGACTGGGAGAAGGAAGATGAGGCCACAGGGGAGCTTGGTGTGGGTCTTGGAGACGGGAGCAT       CTCTCTGTCCTTGGAAGGCGGAGAGGGAGACTTCGCGTTGCTACCCGGCGGCCCCCCAGGGGTATTTT       TCCTTTGCGTGGAGGGGCCCCTGGACAGAGAGAGCCGCGATCTGTATGAGTTACTACTGGTGGCCACG       GACGCGGGGTCCCCGCCGCTGAGCACGGAGGAGACGCTGCTACTCCGGGTCGCTGACCTCAATGACCA       ACCACCTCTCTTCAGCCAACAGCATTACAAGGCCTCAGTGTCCGAGGCCGCGGCCCCTGGCACTGTAG       TCATGTGGGTCAGCGCCTCCGATGCCGACGAGGCAGGCAGTGATCACGCCTGGCTGCGCTACACTGTA       GTCCAACTCTCGGCTCCCTGCAATCTCGGCTCCCTGCAATCAAAGATGGTCCACACCGCAGAGTGTGG       ACCATCTTTTGCCATTGATTCCGAAAGCGGTGCGATCAGCACTATCCGGACTCTAGACCGAGAGGTCC       AGGAGGCGGTGGAGCTGAAAGTGGTGGCCCAGGACCTCGGAGAGCCCCCACTCTCTGCCACCTGCCTG       GTGAGCATCACCGTAGATGATGTGAATGACAATGAGCCCATCTTCTGGAGGCAGGTGTACAATGCCAC       CATTGCAGAGCATGCCCCGGTTGGACACTGCTTTCTGCAGCTTATATCTGCTCAAGTTGCCTCTGTCA       AAATCAAACACAAACACAAGGAGATACACGAGAAACACAATCTTGCCTATATTTCCTGTCCAGCAGGC       ACCATCTATGTCATAACCTGGGCAGATGGTGCTGCTGCCTTTAGTGGGACAGACTTTGCATTCAGTTC       TGATGAACTTCAAGCCTTTGTTCTCAAGTCTCTGTTCTGTGAATTAGGAGAAGGAGAGTTAATCAATT       GGGTGGCACTGGATCGTGAGCACCGGGGGCACCATGAGATGACTGTGCTAGTGACAGACCGCGGCTCC       CCACCACGAAACGCCACCATGGCGGTTTACGTCTCAGTTACTGACATCAATGATAACAGGCCCTTCTT       CCCCCAGTGTCTCCCTGGAAAGGAGTTACACGTGAAGGTTCTGGAAGGTCAACCAGTAAATATGTTGG       TTACAACTGTGTTTGCAAAGGATCCTGATGAAGGAAATAATGCAGAAGTTACATACTCAGTATCTTCA       GAAGATAGTTCTGATCACTTTAAGATTGACGCCAACAATGGTGAAATAAGAACAACCACAATACTTTC       GTATGATTATAGACCTTCCTACAGAATGAGTGTCATTGCCACTGACCAGGGAGTGCCTCCTCTTCAAG       GACAGGCAGTTGTTAATATTCAGGTGATCCCACTATCCAAAGGGAGAGCAATCATGTCTCAGAATATT       AGACATTTAATTATACCAGAAAATTTGAAGCCCACAAAAATAATGAGCTTGATAAAGTCATCTGATCA       CCTTCAACAACATTATAATGGAAAGTTACATTTTAGTATTGTTGCAGATGATAAGGATGGACACTTTG       AAATAGACAGCTCAACCGGAGACTTGTTTCTTTCTAAGGAACTTGATTATGAGACGACATCTCATTAT       CTTTTCAGAGTGATTACTACAGACCATAGCAAAAACCTTTCCCTGAGTAGCACAGTCTTCCTTAGTAT       CGATGTGGAAGATCAGAATGACCATTCCCCATCTTTCCAGGATGAGCTCATTGTGATCAGTGTAGAGG       AGAATGTTCCCATAGGAACCCTGGTGTATGTCTTCAATGCCAAAGATGATGACGGCAGTTTTTTGAAC       AGTAGAATACAATACTACATTGAATCCCACAACCCTGGCACGAATCCATTTCTCATCCACCCCTCATT       TGGCACACTAGTCACTGTGTCCCGTCTTGACAGAGAAAGCATTCCAACTGTCATCCTGACAGTAACAG       GATGTAAATGACCACAACCCCACTTTTATTTCTTTCCCCAATGCCCATGTCAAAGAGGATGTCACAGT       GGGCTCCTTGGTCCACCACATAACTGCTCACGATCCAGACGAAGGAAGGAATGGAAAAGTAACATACA       GCATCCTCTCAGGAAATGAAAACATGACGTTTATGCTAGATGAGTCATCAGGCTTACTAACCACAACC       TGTCCTTTGGATTATGAAATGAAAACTCAGCATATTCTGACTGTTCTGGCACTGGATGATGGCACACC       AGCACTTTCTTCATCCCAGACTTTGACAGTTACTGTTCTTGATGTAAATGATGAAGCTCCAGTATTTA       AGCAGCACCTGTATGAAGCCTCAGTGAAAGAAAACCAAAATCCAGGGGAGTTTGTTACCAGGGTTGAA       GCTCTGGACAGAGATTCAGGTATGAGGCTGAATGGAGATCCAGACAGGGAGCTGTGTGCAGGAGGGAA       CCCTCTTGGAAGCAGGGCCCCTCCTGGAAGCAGGACCCCTCCTGAAGGTGGGCTAAGTGCCCAAGCCT       TTGTTCGTGTGGACCTGGAGGACGTGAATGATAATCATCCTGTGTTTAACCCATCAACCTATGTGACG       AGCATCAGTGATGAGACCCAGCCAGGCACCGAGATCATCAATGTTCTTGCCACTGACCAGGACTCTGG       GATATATGGGACAGTGGCTTATGAGCTTATTCCAGGAAACGTGTCGTCCCTTTTTACCATTGACTCCA       CCACAGGAATTATTTACTTAACATTACCTCTTAGTCATTTGGAATCTACCACACTTTCGTTGATGGTC       TCTGCTCAAGACGGTGGTGGGCTCACAGCTGTCATTAATGCCGATGTCACCATACACATTTTCCAGAC       AACTCTGGCACCTGCTGAGTTTGAAAGGCCTAAGTACACTTTCTTAGTTTATGAAGATGTGCCTGAAG       ATAGTCCCATTGGAACAGTGAAAGCAAGAGAGCCCTTGAATCCACCTAGGAGCTCTGTAATACACCTG       CAAGTTAGAGTTTTGGATGCCAATGACCACAGTCCTTCTTTTCCCACACTTTATTACCAGTCCTCTGT       GAGAGAAGATGCTGAAGTGGGAACAGTGGTTCTTGTGCTTTCAGCTGTGGACAAGGATGAAGGCCTGA       ATGGGCAAACTGAGTATTTTCTGACTGATGAGGCTTGTGGTGCATTCACCATTGATCCTATGTCAGGC       ACATTAGAAACCAGCAACACCCTCGACCGTGAAGCCAGATCTCAGCATACATTTAGTGCTGTGGCCAG       AGACTGTAGCATCCAGGGTTCACGAAGCACCACTGTAATTATAAAAGTATATGTCACTGATGTTAATG       ACAATGATCCAGTTTTGGAACAGAACCCTTTTGATGTGTTTCTTTCCCCCGAGTCGCCTACAAACCAG       ACAACTGTCATTGTGAGAGCTGATGACCTGGACTTGGGGCCCAATGGAACTGTGGACTCCGATGACTC       CCCGCTGCTGGACGACTTCCACGTGCACCCGGACACCGGCATCATCCGCACTGCGCGGCGCCTGGACC       GCGAGCGGCGGGACCACTACAGCTTCGTCGCCGCCACGCTGCTGGGCGCTGTGGTGCAGGTGGAGATT       CGCGTCAACGACGTGAATGACCACTCGCCCCGCTTTCCCCTCGACTCCCTGCAACTCGACGTCTCCGA       GCTCAGCCCGCCAGGGACCGCCTTCCGCCTGCCAGTTGCCCACGATCCGGACGCCGGACTGTTCAGCA       CTCAGGGCTACACCCTGGTGCAACCGTCCGACCTGCCCAAGGACCCCGCAGGCCCGTTCCCCCAGTTG       CGCTACCGGACTCCGGGGCCACTACCGTCACCGCTTTTGCCAGGCTCCTCGTCACCCCTGGAGCCTCT       AGATCTGGTGCTGCTGCGGCGCTTGGACCGAGAGGAGGCGGCGGCGCACCGGCTGCAGATCGAGGCAT       GGGACGGCGGCCGACCCCGGCGCACCGGCCTCCTGAGCGTGGAGCTGCGCGTGCTGGATGAGAACGAC       AACCCGCCGGTCTTTGAGCAGGACGAGTCCCGCGCCGCGGTGCGAGAGCACGCCCAGCCGGGCGCCGA       GGTCTGTCGCGTGCGCGCCACCGCCCGCGACGTGGGGCCCAATGGCTTCGTGCGCTACAGCGTCCGCG       CCCGGCAAGTGCCTGGGGCGGGTAGCGGCGGCGGGGCACTGGGCGACGCGGCCTACTTCGCGTTGGTG       GTGGAGGCCCGCGATGGAGGCGCCGAGCATGAGGTTGCCGCGGTGCGTGTGTCCATCGCCGTGCTGGA       CGTGAATGACAACCGGCCAGCAATTCACGTGCTCTTTCTCACAGAGGGAGGTGTCGCCCGTGTCTCTG       AAGGCGCCCGCCCGGGCGACTACGTGGCTCGCGTCTCGGTGTCTGACGCGGGCGGTGACTGGGAGAAG       GAAGATGAGGCCACAGGGGAGCTTGGTGTGACAGCCTCTGATGCAGATTCAGGACTCTATGGCTTTAT       TGAATATTCTCTTTATGATGGATTCCTGAGCTATGAAGCACCTCAGGCATTCCGGATCGACCCTCATG       ATGGGCAAATCTGTGTTTCTCAAGATATCGACAGGGAAAGGGATCCAGCTACCTATGATCTCCTGGTG       GAAGCTAAGGATGGGTTTGAAATCATGCCAGGTGCTTCATTTGAATTATTCGAGATAAATTCTGACAC       TGGAGAGGTAGTGACAACCACCATACTTGACAGAGAAATTCAAGAAGTCTTCACCCTTCGAGTACTAG       TACGAGATGGGGGATTCCCTTCATTGTCCAGCACCACAACAATCCTCTGCACTGTTGAAGATGAAAAC       GATCACGCACCAGAGTTTATTGTTTCCAGTTATGACATTGAGGTTCTGGAAAACCAGGAACCAGAGGT       TGTCTATACGGTTTTAGCCTCTGATATGGATGCTGGCAATAACAGAGCTGTTGAATATCACATAATTG       ACTCCTCAGAACCAATCTTTTACAGGATTTCTTCTGGTGATCTCGGCGGAAAGTTCTCCATTCACCCG       CGGCTGGGCACTATTCGCACCCGGAAGCCCCTGGATCACGAGACGCAGCCCGTGGTTGTGCTCACGGT       GCAGGCGCAGCTCGGCAGCGCCCCAGCCTGCAGCAGCACCGAGGTCAACATAACAGTCATGGATGTCA       ATGACAACCACCCAGCGTTCCTCAGGACCTCGGATGAGATTAGAATATCCCAGACCACGCCCCCTGGC       ACAGCCTTGTACCTCGCACGTGCGGAAGACAGAGACAGTGGGCGGAACGGACTCATCCGGTACTCCAT       CGCCAGCCCGCAGCCAGGCGTCTTTGCCATCGACAGAGCCCTGGGGGTGCTGTTCCTCAACGGCAGCC       TGGGCGCGGGCGAGCAGCGGGAGCTCACGCTGACTCTCAGGGCCGAGGACCAAGGCGTGCATCCTCAG       GCAGCCCTGCTGGTGCTGACAGTCGTTATCGAGAAACGCGAACACAGCCCATCCTGGACTTTCGAACA       TTTGGTCTATCAAGTGGAAGTCAGTACTTCTATTGTGACTGTTAAAGCTTTTGCTCCTGACTCAATTC       AGGACAGCATGAAATATTCAATTTTTAGTGGAAATGAAGATGGAGTTCTTTCCCTGTGCTCTAAGTCA       GGTGTGGTGAACTGCCTTGCTTCTCTCAGTCACACAGACTTTCTCTCCCTGAAATTTGAATCTTCGGT       GAAGGGACACCAAGACAGAGACAAATTACAGCCAATTCATCTTGATGACAACAACTCAAAGAAGCTGT       GCTTTACATTCCCTAGAGCCACTCAGGCTCTTGTATTCACTGGGCACTGTCTTTCTGATACATCTCTC       CCCGGTTGGGTTTTTGCTACCGACTTGGACAGTGGTTTGAACGGCCTGATTGAGTATTCTATTCTGTC       TGGCAACCAAGAAGAAGCATTCCAGATTGATGCACTGAGTGGTGTGATAACAACAAAAGCGATTCTAG       ATTACGAGCTCACCAGCTCCTACAGCTTGATTGTCCAAGCCACAGATAAAGGGATGCCCAGGCTTTCT       AATACGACTGTAATCAAGGTACAGGTGACTGATATAAATGACAATGCCCCAGCTTTTCTCCCCTCTGA       AGCAGTGGAAATTACAGAAGTCATGACTATTTCAGAAGATTCTTTGCCTGGTGTAATTGTGACTCATG       TGTCAGTTCATGATGTGGATTTGAATTCAGCTTTCATATTCAGTTTTGCCAAAGAGAGTAATCCTGGA       ACCAAGTTTGCTATTGATCAGAACACTGGAGTGGTGGTGTTGGTGAAAACATTGGATTTTGAAGAAAT       GACTGAATATGAGCTGCTCATCCAAATTTCTGATTCAGTGCACTACACAGAGGGAGCACTTGTAGTCC       GTGTGCTGGATGTCAATGATAATCCACCAGTGTTTTCTCAAGATTTCTATCAGGTCACAGTTCCTGAA       TCAATACCTGTGGGGTATTCAGTGCTGACTCTGTCAGCCACAGACTTAGAAAGCAATGAGAACATTTC       TTACAGAATTCTATCCTCTTCTAAGGAATTCTCCATTGATCCTAAGAATGGCACAATATTTACTATCA       GTCCCGTATTACTTCTGGATACAATATCAACAACTCGATTTCTTGTGGAAGCCAGTGATGGTGGAAAT       CCTGACCCGAGAGCTCTTACTTTAGTGGAGATAGGAATAGAAGATATGAACAATTATGCCCCTGAATT       CACAGTCAAATCCTATAATCTTAGCCTAAGTGAGGATGCTCTGGTTGGAAGCACGCTTGTTACATTTT       CAAACATCGACCATGACTGGACCCGTGAAAACACATATGTTGAATATTCCATCATCAGTGGTAATTCA       CAGAACAATTTTCATGTGGAAACTAAGTTCTTTCATTCAGAATATCCTTATAAGCAAGTCGGTTATCT       TGTGTTGCTTCACAGTCTGGACAGAGAAGCAAGTGCTAGCCATGAGCTTGTCATTCTGGCATCTGACA       GTGGCTGCCCTCCATTGAGTTCCACAGCTGTCATATCAATACAAGTACTTGATGTCAATGACAATCCC       CCAAACTTCAGCAGCCTGAGCTATCACACCCATGTCAAGGAAAGCACCCCTCTAGGGAGTCACATCAC       TGTGGTCTCAGCAAATGACCGTGACACAGGGTCACATGCAGAAATCATCTACAACATCATCTCTGGAA       ATGAGAAGGGACATTTTTACTTAGAAGAAAACACTGGAGTTCTTTATTTGATTAAACCTCTGGATTAT       GAAAAAATGACAAAATTCACCTTAACTGTCCAAGCTTCAGATGCAGAAAAGAAACATTTTTCTTTTGC       AGTTGTGTTTGTCAGTGTCCTGGATGATAACGACCATGCACCTCAGTTTATGTTCTCAAGCTTCAGCT       GTATTGTTCCAGAAAATCTGCCTATTTCCTCTACCATATGCTCTATAAATGCTCTGGATTTTGATGCT       GGTCCGTATGGAGAATTGACCTATTCTATTGTATCACCCTGTTTTCTCACTCATGGAATGTCTTATGA       TCATGATCTCTTCCTCATTGACCCTTTGACAGGGGATATTCATGCTAAGCAAATCCTTGACTATGAAA       ATGGCAATAAATACTGCCTCACAGTCCAAGCCAAAGACAAAGGTGATGCAACTGCCTCCTTAGTGGTC       TGGGTGGATATTGAAGGGATAGATGAATTTGAGCCCATTTTCACTCAAGATCAGTATTTTTTCACCCT       CCCAGAAAAGAATAAAGACAGACAGTTGATTGGCAGAGTGGAAGCCTCAGATGCAGATGCTGGTATTG       ATGGAGTCATTCTTTACTCCCTTGGAACCTCATCTCCTTTCTTTTCAGTAAATAGAACCAATGGAAAT       ATTTATTTGATTAGAGCCCTTCCCCTAATAAAAAGTCAACTCAACAAAGAAGACACCTTGGAAATGAA       AATAATCGCTCATAGTCCCAAATCAGATTCCAAGTTTGCATCTTGCACTGTTTTTGTGAATGTGTCTT       TCTCCTCTGAAGGAACACCCTTGGCAGTGTTCGCCAGCAGCTTTTCAATCAGCCTGGTGGTCTCCTTT       TTAGTGTTTCTGATACTCATCTGCATTCTAATTGTAATGATTTTAAGACATAAACAAAAAGACACAAT       AAACAATTATGAGGAGAAGAAAACCTCATCTTTAGATGCGGACTTGAGAGTGACCCGGGATGCCAGTG       TGCTCAAAGCCTTCCAGAAAACTGACGACTGCAGTAACGAGGTGGTCCCTGTGGATGCCACTCCGGAA       TGGTTGAGTTTAATAAGTATCATGGAGAAGGATATTGTCAATCTGTACAGATACTCAAACTCCAGTGG       CCACTGTTCTGTGGAAGGAGAAACTGCAGAAGATAAGGAAATCCAGAGGATAAATGAGCATCCCTACA       GAAAGTGCTCAGACTCAGCTCTGAGTGACCACGAGTCCAGGGTGCCAGACTCGGGTATCCCGAGGGAC       TCAGACCAGCTCTCCTGCCTATCTGGGGAAACTGATGTGATGGTGACTGCCGAAACAGCAGAAGCCAG       CCAAACATTTGGGGAAGGAGATCAAGGGGAAGGCTGCAGCACCACCTGTGCTCAAAATAATGTGTTAC       CCCAGACAGTTCAGAAGAGAGAGGCAAAAGAGAGCATCCTGGCTGACGTTAGAAAAGAGTCTGTCTTT       ATTTCAGGTGATCAGGAAGTAAGGTGTGCAGCTCTTTCAACTCAGACGACCTCTGATCATGATGGAAA       AGACAACTATCACTGGAATTATCTTCTTAGTTGGGAGCCCAAATTCCAACCTCTTGCCTCAGTATTTA       ATGATATTGCAAAACTAAAGGATGAACATTTGCATATGCCTGGCATTCCAAAAGAGAAGAAATCTTTT       GTTTTTCCACCCCCTTTGATAACAGCAGTAGCCCAGCCTGGGATTAAAGCAGTCCCACCAAGAATGCC       GGCAGTAAACCTGGGGCAGGTGCCTCCGAAACACCCACGCTCTCCCATCCCCTACCATCTTGGTTCTC       TGCCAGAAGGCATGACTCCCAATTTTTCTCCATCTCTTTCCCTATTGACGATGCAGCCTCCTGCCTTG       TCTCCACTGTTGAGAGAAGGAGAATTATTAGGAACACACATCAGTGGTACATGCCATGAACTTAAAGC       AGAAGATGAAGTTCAAATA TGA   AACCACTGGGATGCCAAGTACCTGCTCACCATTGGTCATGAATGAA           TGAACAAAATGTTTTCAAGCCGGCAACTCGAGATTGGGCTCATTTTTATCTAAAAGCAAGTGATGTAA           TTTAGTTAGAGTTTTTAAAACTTCCCCATTAAAGTTTCTCCAATTTCAAAAAAAAAAAAAAAAAAAA                                                   NOV50i, CG58567-06   SEQ ID NO: 1082   3361 aa   MW at 367309.1kD               Protein Sequence                     MEKCGLKEEGSYADIDPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSS           SPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVRED       AQPGAEVCRVPATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQ       AWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDA       DGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVAT       DAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTV       VQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCL       VSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISAQVASVKIKHKHKEIHEKHNLAYISCPAG       TIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGS       PPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS       EDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNI       RHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHY       LFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLN       SRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVIL       DVNDHNPTFISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTT       CPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVE       ALDRDSGMRLNGDPDRELCAGGNPLGSRAPPGSRTPPEGGLSAQAFVRVDLEDVNDNHPVFNPSTYVT       SISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMV       SAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNPPRSSVIHL       QVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEACGAFTIDPMSG       TLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ       TTVIVRADDLDLGPNGTVDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEI       RVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQL       RYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDEND       NPPVFEQDESRAAVREHAQPGAEVCRVRATARDVGPNGFVRYSVRARQVPGAGSGGGALGDAAYFALV       VEARDGGAEHEVAAVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDAGGDWEK       EDEATGELGVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV       EAKDGFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEN       DHAPEFIVSSYDTEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDSSEPIFYRISSGDLGGKFSTHP       RLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPG       TALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQ       AALLVLTVVIEKREHSPSWTFEHLVYQVEVSTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKS       GVVNCLASLSHTDFLSLKFESSVKGHQDRDKLQPIHLDDNNSKKLCFTFPRATQALVFTGHCLSDTSL       PGWVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLS       NTTVIKVQVTDINDNAPAFLPSEAVEITEVMTISEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPG       TKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPE       SIPVGYSVLTLSATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTRFLVEASDGGN       PDPRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNS       QNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNP       PNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDY       EKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDA       GPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVV       WVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNRTNGN       IYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPIAVFASSFSISLVVSF       LVFLILICILIVMILRHKQKDTINNYEEKKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPE       WLSLISIMEKDIVNLYRYSNSSGHCSVEGETAEDKEIQRINEHPYRKCSDSALSDHESRVPDSGIPRD       SDQLSCLSGETDVMVTAETAEASQTFGEGDQGEGCSTTCAQNNVLPQTVQKREAKESILADVRKESVF       ISGDQEVRCAALSTQTTSDHDGKDNYHWNYLLSWEPKFQPLASVFNDIAKLKDEHLHMPGIPKEKKSF       VFPPPLITAVAQPGIKAVPPRMPAVNLGQVPPKHPRSPIPYHLGSLPEGMTPNFSPSLSLLTMQPPAL       SPLLREGELLGTHISGTCHELKAEDEVQI                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 50B.  
               TABLE 50B                       Comparison of the NOV50 protein sequences.                                        NOV50a ------------------------------------------------------------           NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h MEKCGLKEEGSYADIDPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLP       NOV50i MEKCGLKEEGSYADIDPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLP               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h SPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDN       NOV50i SPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDN               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGD       NOV50i PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGD               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h AAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPA       NOV50i AAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPA               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h IHVLFLTEGGVARVSEGARPGDYVARVSVSDADGVIGKITAIDMDS--------------       NOV50i IHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLE               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h ------------------------------------------------------------       NOV50i GGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADL               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h ---------------------------------------------------------GK-       NOV50i NDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSL               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h ------------------------------------------------------------       NOV50i QSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLVSIT               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h --------------------------------NG-QLLYFLLSD----------------       NOV50i VDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQLISAQVASVKIKHKHKEIHEKHNLAYIS               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h ----------G------------------------KFFKMNPNTGELINWVALDREHRGH       NOV50i CPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGH               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT       NOV50i HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG       NOV50i VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h VPPLQGQAVVNIQEL---------------------------------------------       NOV50i VPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKL               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h --------D--------------------YETTSHYLFRVITTDHSKNLSLSSTVFLSID       NOV50i HFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSID               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h VEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNP       NOV50i VEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNP               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h FLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPT       NOV50i FLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPT               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h FISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTT       NOV50i FISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTT               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h CPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNP       NOV50i CPLDYEMKTQHILTVTALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNP               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h GEFVTRVEALDRDSVFLNTRELNMCFLAFYDAVFK----------NGGLSAQAFVRVDLE       NOV50i GEFVTRVEALDRDSGNRLNGDPDRELCAGGNPLGSRAPPGSRTPPEGGLSAQAFVRVDLE               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGTYGTVAYELIPGNVSSLFTID       NOV50i DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGTYGTVAYELIPGNVSSLFTID               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h STTGIIYLTLPLSHLESTTLSLNVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYT       NOV50i STTGIIYLTLPLSHLESTTLSLNVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYT               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h FLVYEDVPEDSPIGTVKAREPLNPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAE       NOV50i FLVYEDVPEDSPIGTVKAREPLNPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAE               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h VGTVVLVLSAVDKDEGLNGQTEYFLTDEACGAFTTDPMSGTLKTSNTLDREARSQHTFSA       NOV50i VGTVVLVLSAVDKDEGLNGQTEYFLTDEACGAFTIDPMSGTLKTSNTLDREARSQHTFSA               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h VARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDL       NOV50i VARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDL               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h GPNGTVDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVND       NOV50i GPNGTVDSDDSPLLDDFNVHPDTGIIRTARRLDRERRDHYSFVAATLLGAVVQVEIRVND               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       N0V50h VNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGP       NOV50i VNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGP               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h FFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGL       NOV50i FFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGL               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h LSVELRVLDENDNPPVFEQDESRAAVREHAQPGAEVCRVRATARDVGPNGFVRYSVRARQ       NOV50i LSVELRVLDENDNPPVFEQDESRAAVREHAQPGAEVCRVRATARDVGPNGFVRYSVRARQ               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h VPGAGSGGGALGDAAYFALVVEARDGGAEHEVAAVRVSIAVLDVNDNRPAIHVLFLTEGG       NOV50i VPGAGSGGGALGDAAYFALVVEARDGGAEHEVAAVRVSIAVLDVNDNRPAIHVLFLTEGG               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h VARVSEGARPGDYVARVSVSDAGGDWEKEDEATGELGVTASDADSGLYGFIEYSLYDGFL       NOV50i VARVSEGARPGDYVARVSVSDAGGDWEKEDEATGELGVTASDADSGLYGFIEYSLYDGFL               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h SYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGFEIMPGASFELFEINSDTG       NOV50i SYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGFEIMPGASFELFEINSDTG               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h EVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVL       NOV50i EVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVL               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h ENQEPEVVYTVLASDMDAGNNRAVEYHIIDSSEPIFYRISSGDLGGKFSIHPRLGTIRTR       NOV50i ENQEPEVVYTVLASDMDAGNNRAVEYHIIDSSEPIFYRISSGDLGGKFSIHPRLGTIRTR               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h KPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPG       NOV50i KPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPG               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h TALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRA       NOV50i TALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRA               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h EDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSTSIVTVKAFAPDSIQDSMKYS       NOV50i EDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSTSIVTVKAFAPDSIQDSMKYS               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h IFSGNEDGVLSLCSKSGVVNCLASLSHTDFLSLKFESSVKGHQDRDKLQPIHLDDNNSKK       NOV50i IFSGNEDGVLSLCSKSGVVNCLASLSHTDFLSLKFESSVKGHQDRDKLQPIHLDDNNSKK               NOV50a ------------------------------------------------------------       NOV50b ------------------------------------------------------------       NOV50c ------------------------------------------------------------       NOV50d ------------------------------------------------------------       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ------------------------------------------------------------       NOV50h LCFTFPRATQALVFTGHCLSDTSLPGWVFATDLDSGLNGLIEYSILSGNQEEAFQIDALS       NOV50i LCFTFPRATQALVFTGHCLSDTSLPGWVFATDLDSGLNGLIEYSILSGNQEEAFQIDALS               NOV50a ------------------LIVQATDKGMPRLSNTTVIKVQVTDTNDNAPAFLPSEAVEIT       NOV50b ----------------------------------------------------------GS       NOV50c ----------------------------------------------------------GS       NOV50d ----------------------------------------------------------GS       NOV50e ------------------------------------------------------------       NOV50f ------------------------------------------------------------       NOV50g ----------------------------------------------------------GS       NOV50h GVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEIT       NOV50i GVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEIT               NOV50a EVMTISEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDF       NOV50b EVMTISEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDF       NOV50c EVMTISEDSLPGVIVTHVSVHDVDTNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDF       NOV50d EVMTISEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDF       NOV50e ------------------------------------------------------------       NOV50f EVMTISEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDF       NOV50g EVMTISEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDF       NOV50h EVMTISEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDF       NOV50i EVMTISEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDF               NOV50a EEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLS       NOV50b EEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLS       NOV50c EEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLS       NOV50d EEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLS       NOV50e --MTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLS       NOV50f EEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLS       NOV50g EEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLS       NOV50h EEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLS       NOV50i EEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLS               NOV50a ATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTRFLVEASDGGNPDPR       NOV50b ATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLR       NOV50c ATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLR       NOV50d ATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLR       NOV50e ATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLR       NOV50f ATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLR       NOV50g ATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLR       NOV50h ATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTRFLVEASDGGNPDPR       NOV50i ATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTRFLVEASDGGNPDPR               NOV50a ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII       NOV50b ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII       NOV50c ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII       NOV50d ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII       NOV50e ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII       NOV50f ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII       NOV50g ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII       NOV50h ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII       NOV50i ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII               NOV50a SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAV       NOV50b SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAV       NOV50c SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAV       NOV50d SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAV       NOV50e SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAV       NOV50f SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAV       NOV50g SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAV       NOV50h SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAV       NOV50i SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAV               NOV50a ISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEK       NOV50b ISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEK       NOV50c ISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEITYNIISGNEK       NOV50d ISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEK       NOV50e ISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEK       NOV50f ISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEK       NOV50g ISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEK       NOV50h ISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEK       NOV50i ISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAETIYNIISGNEK               NOV50a GHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFM       NOV50b GHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFM       NOV50c GHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFM       NOV50d GHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFM       NOV50e GHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFM       NOV50f GHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFM       NOV50g GHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFM       NOV50h GHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFM       NOV50i GHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQFM               NOV50a FSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPL       NOV50b FSSFSCIVPENLPISSTIRSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPL       NOV50c FSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPL       NOV50d FSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPL       NOV50e FSSFSCIVPENLPISSTICSTNALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPL       NOV50f FSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPL       NOV50g FSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPL       NOV50h FSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPL       NOV50i FSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPL               NOV50a TGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLP       NOV50b TGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLP       NOV50c TGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLP       NOV50d TGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLP       NOV50e TGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLP       NOV50f TGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLP       NOV50g TGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLP       NOV50h TGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLP       NOV50i TGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLP               NOV50a EKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNRTNGNIYLIRALPLIKSQLNK       NOV50b EKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNK       NOV50c EKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNK       NOV50d EKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNK       NOV50e EKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPSLSVNKTNGNIYLIPALPLIKSQLNK       NOV50f EKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNTYLIRALPLIKSQLNK       NOV50g EKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRALPLIKSQLNK       NOV50h EKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNRTNGNIYLIRALPLIKSQLNK       NOV50i EKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNRTNGNIYLIRALPLIKSQLNK               NOV50a EDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISLVVSFLVFLILIC       NOV50b EDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISLVVSFLVFLILIC       NOV50c EDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISLVVSFLVFLTLIC       NOV50d EDTLEMKIIAHSPKSDSKFASCTVFVNVSVD-----------------------------       NOV50e EDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISLVVSFLVFLTLIC       NOV50f EDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISLVVSFLVFLILIC       NOV50g EDTLEMKIIAHSPKSDSKFASCTVFVNVSVD-----------------------------       NOV50h EDTLEMKTTAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISLVVSFLVFLILIC       NOV50i EDTLEMKITAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSISLVVSFLVFLILIC               N0V50a ILIVMILRHKQKDTINNYEEKKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPE       NOV50b ILIVNILRHKQKDTINNYEEKKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPE       NOV50c ILIVMILRHKQKDTINNYEEKKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPE       NOV50d ------------------------------------------------------------       NOV50e ILIVMILRHKQKDTINNYEEKKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPE       NOV50f ILIVMILRHKQKDTINNYEEKKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPE       NOV50g ------------------------------------------------------------       NOV50h ILIVMILRHKQKDTINNYEEKKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPE       NOV50i ILIVMILRHKQKDTINNYEEKKTSSLDADLRVTRDASVLKAFQKTDDCSNEVVPVDATPE               NOV50a WLSLISIMEKDIVNLYRYSNSSGHCSVEGETAEDKEIQRINEHPYRKCSDSALSDHESRV       NOV50b WLSLISIMEKDIVNLYRHSNSSGHCSVEGETAEDKEIQRINEHPYRKCSDSALSDHESRV       NOV50c WLSLISIMEKDIVNLYRHSNSSGHCSVEGETAEDKEIQRINEHPYRKCSDSALSDHESRV       NOV50d ------------------------------------------------------------       NOV50e WLSLISIMEKDTVNLYRHSNSSGHCSVEGETAEDKEIQRINEHPYRKCSDSALSDHESRV       NOV50f WLSLISIMEKDIVNLYRHSNSSGHCSVEGETAEDKEIQRINEHPYRKCSDSALSDHESRV       NOV50g ------------------------------------------------------------       NOV50h WLSLISIMEKDIVNLYRYSNSSGHCSVEGETAEDKEIQRINEHPYRKCSDSALSDHESRV       NOV50i WLSLISIMEKDIVNLYRYSNSSGHCSVEGETAEDKEIQRINEHPYRKCSDSALSDHESRV               NOV50a PDSGIPPDSDQLSCLSGETDVMVTAETAEASQTFGEGDQGEGCSTTCAQNNVLPQTVQKR       NOV50b PDSGIPRDSDQLSCLSGETDVMVTAETAEASQTFGEGDQGEGCSTTCAQNNVLPQTVQKR       NOV50c PDSGIPRDSDQLSCLSGETDVMVTAETAEASQTFGEGDQGEGCSTTCAQNNVLPQTVQKR       NOV50d ------------------------------------------------------------       NOV50e PDSGIPRDSDQLSCLSGETDVMVTAETAEASQTFGEGDQGEGCSTTCAQNNVLPQTVQKR       NOV50f PDSGIPRDSDQLSCLSGETDVMVTAETAEASQTFGEGDQGEGCSTTCAQNNVLPQTVQKR       NOV50g ------------------------------------------------------------       NOV50h PDSGIPRDSDQLSCLSGETDVMVTAETAEASQTFGEGDQGEGCSTTCAQNNVLPQTVQKR       NOV50i PDSGIPRDSDQLSCLSGETDVMVTAETAEASQTFGEGDQGEGCSTTCAQNNVLPQTVQKR               NOV50a EAKESILADVRKESVFISGDQEVRCAALSTQTTSDHDGKDNYHWNYLLSWEPKFQPLASV       NOV50b EAKESILADVRKESVFISGDQEVRCAALSTQTTSDHDGKDNYHWNYLLSWEPKFQPLASV       NOV50c EAKESILADVRKESVFISGDQEVRCAALSTQTTSDHDGKDNYHWNYLLSWEPKFQPLASV       NOV50d ------------------------------------------------------------       NOV50e EAKESILADVRKESVFISGDQEVRCAALSTQTTSDHDGKDNYHWNYLLSWEPKFQPLASV       NOV50f EAKESTLADVRKESVFISGDQEVRCAALSTQTTSDHDGKDNYHWNYLLSWEPKFQPLASV       NOV50g ------------------------------------------------------------       NOV50h EAKESILADVRKESVFISGDQEVRCAALSTQTTSDHDGKDNYHWNYLLSWEPKFQPLASV       NOV50i EAKESILADVRKESVFISGDQEVRCAALSTQTTSDHDGKDNYHWNYLLSWEPKFQPLASV               NOV50a FNDIAKLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPGIKAVPPRMPAVNLGQVPPKHPR       NOV50b FNDIAKLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPGIKAVPPRMPAVNLGQVPPKHPR       NOV50c FNDIAKLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPGIKAVPPRMPAVNLGQVPPKHPR       NOV50d ------------------------------------------------------------       NOV50e FNDIAKLKDEHLHNPGIPKEKKSFVFPPPLITAVAQPGIKAVPPRMPAVNLGQVPPKHPR       NOV50f FNDIAKLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPGIKAVPPRMPAVNLGQVPPKHPR       NOV50g ------------------------------------------------------------       NOV50h FNDIAKLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPGIKAVPPRMPAVNLGQVPPKHPR       NOV50i FNDIAKLKDEHLHMPGIPKEKKSFVFPPPLITAVAQPGIKAVPPRNPAVNLGQVPPKHPR               NOV50a SPIPYHLGSLPEGMTPNFSPSLSLLTMQPPALSPLLREGELLGTHISGTCHELKAEDEVQ       NOV50b SPIPYHLGSLPEGMTPNFSPSLSLLTMQPPALSPLLREGELLGTHISGTCHELKAEDEVQ       NOV50c SPIPYHLGSLPEGMTPNFSPSLSLLTMQPPALSPLLREGELLGTHISGTCHELKAEDEVQ       NOV50d ------------------------------------------------------------       NOV50e SPIPYHLGSLPEGMTPNFSPSLSLLTMQPPALSPLLREGELLGTHISGTCHELKAEDEVQ       NOV50f SPIPYHLGSLPEGMTPNFSPSLSLLTMQPPALSPLLREGELLGTHISGTCHELKAEDEVQ       NOV50g ------------------------------------------------------------       NOV50h SPIPYHLGSLPEGMTPNFSPSLSLLTMQPPALSPLLREGELLGTHISGTCHELKAEDEVQ       NOV50i SPIPYHLGSLPEGMTPNFSPSLSLLTMQPPALSPLLREGELLGTHISGTCHELKAEDEVQ               NOV50a I--       NOV50b IVD       NOV50c IVD       NOV50d ---       NOV50e I--       NOV50f I--       NOV50g ---       NOV50h I--       NOV50i I--               NOV50a (SEQ ID NO: 1066)       NOV50b (SEQ ID NO: 1068)       NOV50c (SEQ ID NO: 1070)       NOV50d (SEQ ID NO: 1072)       NOV50e (SEQ ID NO: 1074)       NOV50f (SEQ ID NO: 1076)       NOV50g (SEQ ID NO: 1078)       NOV50h (SEQ ID NO: 1080)       NOV50i (SEQ ID NO: 1082)                  
 
      Further analysis of the NOV50a protein yielded the following properties shown in Table 50C.  
               TABLE 50C                       Protein Sequence Properties NOV50a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 8; pos. chg 1; neg. chg 1           H-region:   length 3; peak value −4.35           PSG score:   −8.75                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −9.63           possible cleavage site: between 38 and 39                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 690-706               −18.15                             PERIPHERAL   Likelihood =  2.54 (at 195)                         ALOM score: −18.15 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 697           Charge difference: 3.5 C(2.5)-N(−1.0)           C &gt; N: C-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 1b (cytoplasmic tail 690 to 1063)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:    1   Hyd Moment(75):   8.18           Hyd Moment(95):   10.59   G content:   1           D/E content:    2   S/T content:   5                         Score: −4.29       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 22 PRL|SN                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: PKEKKSF (5) at 960           bipartite: none           content of basic residues: 7.1%           NLS Score: −0.04       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: found       LL at 929       LL at 1026       LL at 1037       LL at 1043       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 70.6       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         34.8%: nuclear           26.1%: cytoplasmic           17.4%: mitochondrial            8.7%: vesicles of secretory system            4.3%: vacuolar            4.3%: peroxisomal            4.3%: endoplasmic reticulum                 &gt;&gt; prediction for CG58567-01 is nuc (k = 23)                  
 
      A search of the NOV50a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 50D.  
               TABLE 50D                          Geneseq Results for NOV50a                                             Identities/                   NOV50a   Similarities       Geneseq   Protein/Organism/Length   Residues/   for the   Expect       Identifier   [Patent #, Date]   Match Residues   Matched Region   Value                                             ABP70112   Human NOV28c -  Homo sapiens ,   1 . . . 1063   1063/1063   (100%)   0.0           3361 aa. [WO200272771-A2,   2299 . . . 3361     1063/1063   (100%)           19-SEP-2002]       ABP70111   Human NOV28b -  Homo sapiens ,   1 . . . 1063   1063/1063   (100%)   0.0           3003 aa. [WO200272771-A2,   1941 . . . 3003     1063/1063   (100%)           19-SEP-2002]       ABP70110   Human NOV28a -  Homo sapiens ,   1 . . . 1063   1063/1063   (100%)   0.0           1063 aa. [WO200272771-A2,   1 . . . 1063   1063/1063   (100%)           19-SEP-2002]       ABP43938   FLJ20047 fis clone COL00577 -   105 . . . 1063    959/959   (100%)   0.0             Homo sapiens , 959 aa.   1 . . . 959    959/959   (100%)           [WO200231111-A2, 18-APR-2002]       AAO26793   Human cadherin (CAD) protein, SEQ   1 . . . 1036   366/1073   (34%)   e−148           ID No 16 -  Homo sapiens , 3298 aa.   2245 . . . 3270     543/1073   (50%)           [WO200299042-A2, 12-DEC-2002]                  
 
      In a BLAST search of public sequence databases, the NOV50a protein was found to have homology to the proteins shown in the BLASTP data in Table 50E.  
               TABLE 50E                          Public BLASTP Results for NOV50a                                         NOV50a   Identities/           Protein       Residues/   Similarities for           Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             Q9NXU8   Hypothetical protein FLJ20047 -    105 . . . 1063   959/959   (100%)   0.0             Homo sapiens  (Human), 959 aa.    1 . . . 959   959/959   (100%)       Q9NRU0   Cadherin-like protein VR8 -  Homo     189 . . . 582   391/394   (99%)   0.0             sapiens  (Human), 398 aa (fragment).    5 . . . 398   393/394   (99%)       Q96JQ0   Protocadherin 16 precursor     1 . . . 1036   366/1073   (34%)   e−148           (Cadherin 19) (Cadherin fibroblast   2245 . . . 3270   543/1073   (50%)           1) -  Homo sapiens  (Human), 3298 aa.       Q24292   Dachsous protein precursor     1 . . . 1037   328/1165   (28%)   e−100           (Adherin) -  Drosophila melanogaster     2343 . . . 3471   528/1165   (45%)           (Fruit fly), 3503 aa.       Q8AXB7   Protocadherin -  Brachydanio rerio      3 . . . 605   206/615   (33%)   3e−77           (Zebrafish) (Danio rerio), 4610 aa.   2885 . . . 3471   317/615   (51%)                  
 
      PFam analysis predicts that the NOV50a protein contains the domains shown in the Table 50F.  
               TABLE 50F                          Domain Analysis of NOV50a                                             Identities/               Pfam   NOV50a   Similarities for   Expect           Domain   Match Region   the Matched Region   Value                       cadherin    43 . . . 130   26/108 (24%)   1.6e−14                   64/108 (59%)           cadherin   144 . . . 232   36/108 (33%)   2.5e−12                   66/108 (61%)           cadherin   246 . . . 348   36/113 (32%)     2e−15                   79/113 (70%)           cadherin   362 . . . 452   35/107 (33%)   8.4e−24                   75/107 (70%)           cadherin   466 . . . 563   33/115 (29%)   1.1e−11                   67/115 (58%)           cadherin   577 . . . 671   26/110 (24%)   0.17                   60/110 (55%)                      
 
     Example 51  
      The NOV51 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 51A.  
               TABLE 51 A                       NOV51 Sequence Analysis                                                NOV51 a, CG59534-03   SEQ ID NO:1083   3333 bp           DNA Sequence   ORF Start: ATG at 15   ORF Stop: TAG at 3219                       GCGCTCCAGACAAG   ATG GCGCGGCCGGTCCGGGGAGGGCTCGGGGCCCCGCGCCGCTCGCCTTGCCTT           CTCCTTCTCTGGCTGGTTTTGGTTCGGCTGGAGCCGGTGACCGCCGCGGCCGGCCCGCGGGCGCCCTG       CGCGGCCGCCTGCACTTGCGCTGGGGACTCGCTGGACTGCGGTGGGCGCGGGCTGGCTGCGTTGCCCG       GGGACCTGCCCTCCTGGACGCGGAGCCTAAACCTGAGTTACAACAAACTCTCTGAGATTGACCCTGCT       GGTTTTGAGGACTTGCCGAACCTACAGGAAGTGCAGCACAACAAGATTCGCAGCGTGGAGGGGAGCCA       GCTGAAGGCCTACCTTTCCTTAGAAGTGTTAGATCTGAGTTTGAACAACATCACGGAAGTGCGGAACA       CCTGCTTTCCACACGGACCGCCTATAAAGGAGCTCAACCTGGCAGGCAATCGGATTGGCACCCTGGAG       TTGGGAGCATTTGATGGTCTGTCACGGTCGCTGCTAACTCTTCGCCTGAGCAAAAACAGGATCACCCA       GCTTCCTGTAAGAGCATTCAAGCTACCCAGGCTGACACAACTGGACCTCAATCGGAACAGGATTCGGC       TGATAGAGGGCCTCACCTTCCAGGGGCTCAACAGCTTGGAGGTGCTGAAGCTTCAGCGAAACAACATC       AGCAAACTGACAGATGGGGCCTTCTGGGGACTGTCCAAGATGCATGTGCTGCACCTGGAGTACAACAG       ATTCCATCGCTCGCATTCACCGCAAGGGCTGGAGCTTCTGCCAGAAGCTGCATGAGTTGGTCCTGTCC       TTCAACAACCTGACACGGCTGGACGAGGAGAGCCTGGCCGAGCTGAGCAGCCTGAGTGTCCTGCGTCT       CAGCCACAATTCCATCAGCCACATTGCGGAGGGTGCCTTCAAGGGACTCAGGAGCCTGCGAGTCTTGG       ATCTGGACCATAACGAGATTTCGGGCACAATAGAGGACACGAGCGGCGCCTTCTCAGGGCTCGACAGC       CTCAGCAAGCTGACTCTGTTTGGAAACAAGATCAAGTCTGTGGCTAAGAGAGCATTCTCGGGGCTGGA       AGGCCTGGAGCACCTGAACCTTGGAGGGAATGCGATCAGATCTGTCCAGTTTGATGCCTTTGTGAAGA       TGAAGAATCTTAAAGAGCTCCATATCAGCAGCGACAGCTTCCTGTGTGACTGCCAGCTGAAGTGGCTG       CCCCCGTGGCTAATTGGCAGGATGCTGCAGGCCTTTGTGACAGCCACCTGTGCCCACCCAGAATCACT       GAAGGGTCAGAGCATTTTCTCTGTGCCACCAGAGAGTTTCGTGTGCGATGACTTCCTGAAGCCACAGA       TCATCACCCAGCCAGAAACCACCATGGCTATGGTGGGCAAGGACATCCGGTTTACATGCTCAGCAGCC       AGCAGCAGCAGCTCCCCCATGACCTTTGCCTGGAAGAAAGACAATGAAGTCCTGACCAATGCAGACAT       GGAGAACTTTGTCCACGTCCACGCGCAGGACGGGGAAGTGATGGAGTACACCACCATCCTGCACCTCC       GTCAGGTCACTTTCGGGCACGAGGGCCGCTACCAATGTGTCATCACCAACCACTTTGGCTCCACCTAT       TCACATAAGGCCAGGCTCACCGTGAATGTGTTGCCATCATTCACCAAAACGCCCCACGACATAACCAT       CCGGACCACCACCGTGGCCCGCCTCGAATGTGCTGCCACAGGTCACCCAAACCCTCAGATTGCCTGGC       AGAAGGATGGAGGCACGGATTTCCCCGCTGCCCGTGAGCGACGCATGCATGTCATGCCGGATGACGAC       GTGTTTTTCATCACTGATGTGAAAATAGATGACGCAGGGGTTTACAGCTGTACTGCTCAGAACTCAGC       CGGTTCTATTTCAGCTAATGCCACCCTGACTGTCCTAGAGACCCCATCCTTGGTGGTCCCCTTGGAAG       ACCGTGTGGTATCTGTGGGAGAAACAGTGGCCCTCCAATGCAAAGCCACGGGGAACCCTCCGCCCCGC       ATCACCTGGTTCAAGGGGGACCGCCCGCTGAGCCTCACTGAGCGGCACCACCTGACCCCTGACAACCA       GCTCCTGGTGGTTCAGAACGTGGTGGCAGAGGATGCGGGCCGATATACCTGTGAGATGTCCAACACCC       TGGGCACGGAGCGAGCTCACAGCCAGCTGAGCGTCCTGCCCGCAGCAGGCTGCAGGAAGGATGGGACC       ACGGTAGGCATCTTCACCATTGCTGTCGTGAGCAGCATCGTCCTGACGTCACTGGTCTGGGTGTGCAT       CATCTACCAGACCAGGAAGAAGAGTGAAGAGTACAGTGTCACCAACACAGATGAAACCGTCGTGCCAC       CAGATGTTCCAAGCTACCTCTCTTCTCAGGGGACCCTTTCTGACCGACAAGAAACCGTGGTCAGGACC       GAGGGTGGCCCTCAGGCCAATGGGCACATTGAGAGCAATGGTGTGTGTCCAAGAGATGCAAGCCACTT       TCCAGAGCCCGACACTCACAGCGTTGCCTGCAGGCAGCCAAAGCTCTGTGCTGGGTCTGCGTATCACA       AAGAGCCGTGGAAAGCGATGGAGAAAGCTGAAGGGACACCTGGGCCACATAAGATGGAACACGGTGGC       CGGGTCGTATGCAGTGACTGCAACACCGAAGTGGACTGTTACTCCAGGGGACAAGCCTTCCACCCCCA       GCCTGTGTCCAGAGACAGCGCACAGCCAAGTGCGCCAAATGGCCCGGAGCCGGGTGGGAGTGACCAAG       AGCATTCTCCACATCACCAGTGCAGCAGGACTGCCGCTGGGTCCTGCCCCGAGTGCCAAGGGTCGCTC       TACCCCAGTAACCACGATAGAATGCTGACGGCTGTGAAGAAAAAGCCAATGGCATCTCTAGATGGGAA       AGGGGATTCTTCCTGGACTTTAGCAAGGTTGTATCACCCGGACTCCACAGAGCTACAGCCTGCATCTT       CATTAACTTCAGGCAGTCCAGAGCGCGCGGAAGCCCAGTACTTGCTTGTTTCCAATGGCCACCTCCCC       AAAGCATGTGACGCCAGTCCCGAGTCCACGCCACTGACAGGACAGCTCCCCGGGAAACAGAGGGTGCC       ACTGCTGTTGGCACCAAAAAGC TAG   GTTTTGTCTACCTCAGTTCTTGTCATACCAATCTCTACGGGAA           AGAGAGGTAGGAGAGGCTGCGAGGAAGCTTGGGTTCAAGCGTCACTCATCTGTACATAGTTGT           AACTCC                                           NOV51a, CG59534-03   SEQ ID NO:1084   1068 aa   MW at 116452.8 kD           Protein Sequence                     MARPVRGGLGAPRRSPCLLLLWLVLVRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPS           WTRSLNLSYNKLSEIDPAGFEDLPNLQEVQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPH       GPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGL       TFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIAR       IHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHN       EISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLK       ELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCANPESLKGQSIFSVPPESFVCDDFLKPQIITQP       ETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTF       GHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTVARLECAATGHPNPQIAWQKDGG       TDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVS       VGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTER       AHSQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPS       YLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAGSAYHKEPWK       AMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSPDSAQPSAPNGPEPGGSDQEHSPH       HQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGDSSWTLARLYHPDSTELQPASSLTSG       SPERAEAQYLLVSNGHLPKACDASPESTPLTGQLPGKQRVPLLLAPKS                                     NOV51b, CG59534-01   SEQ ID NO:1085   5101 bp           DNA Sequence   ORF Start: ATG at 77   ORF Stop: TAG at 3308                       ATCCTCCTACCTCAGTCTACTGAGTAGCTAGGACTACAGGCATGTGCCACCACACCTGGCTAGTTTTT               ATTTTTTG   ATG AGATGGGATCTTGCTGTGTTGCCCAGACTGGTCTTGATCTCCTGGGCTCAAGTGATC       CTCCTGCCTTGGCCTGCGGCCGCCTGCACTTGCGCTGGGGACTCGCTGGACTGCGGTGGGCGCGGGCT       GGCTGCGTTGCCCGGGGACCTGCCCTCCTGGACGCGGAGCCTAAACCTGAGTTACAACAAACTCTCTG       AGATTGACCCTGCTGGTTTTGAGGACTTGCCGAACCTACAGGAAGTGTACCTCAATAATAATGAGTTG       TCGCAGCGTGGAGGGGAGCCAGCTGAAGGCCTACCTTTCCTTAGAAGTGTTAGATCTGAGTTTGAACA       ACATCACGGAAGTGCGGAACACCTGCTTTCCACACGGACCGCCTATAAAGGAGCTGAACCTGGCAGGC       AATCGGATTGGCACCCTGGAGTTGGGAGCATTTGATGGTCTGTCACGGTCGCTGCTAACTCTTCGCCT       GAGCAAAAACAGGATCACCCAGCTTCCTGTAAGAGCATTCAAGCTACCCAGGCTGACACAACTGGACC       TCAATCGGAACAGGATTCGGCTGATAGAGGGCCTCACCTTCCAGGGGCTCAACAGCTTGGAGGTGCTG       AAGCTTCAGCGAAACAACATCAGCAAACTGACAGATGGGGCCTTCTGGGGACTGTCCAAGATGCATGT       GCTGCACCTGGAGTACAACAGCCTGGTAGAAGTGAACAGCGGCTCGCTCTACGGCCTCACGGCCCTGC       ATCAGCTCCACCTCAGCAACAATTCCATCGCTCGCATTCACCGCAAGGGCTGGAGCTTCTGCCAGAAG       CTGCATGAGTTGGTCCTGTCCTTCAACAACCTGACACGGCTGGACGAGGAGAGCCTGGCCGAGCTGAG       CAGCCTGAGTGTCCTGCGTCTCAGCCACAATTCCATCAGCCACATTGCGGAGGGTGCCTTCAAGGGAC       TCAGGAGCCTGCGAGTCTTGGATCTGGACCATAACGAGATTTCGGGCACAATAGAGGACACGAGCGGC       GCCTTCTCAGGGCTCGACAGCCTCAGCAAGCTGACTCTGTTTGGAAACAAGATCAAGTCTGTGGCTAA       GAGAGCATTCTCGGGGCTGGAAGGCCTGGAGCACCTGAACCTTGGAGGGAATGCGATCAGATCTGTCC       AGTTTGATGCCTTTGTGAAGATGAAGAATCTTAAAGAGCTCCATATCAGCAGCGACAGCTTCCTGTGT       GACTGCCAGCTGAAGTGGCTGCCCCCGTGGCTAATTGGCAGGATGCTGCAGGCCTTTGTGACAGCCAC       CTGTGCCCACCCAGAATCACTGAAGGGTCAGAGCATTTTCTCTGTGCCACCAGAGAGTTTCGTGTGCG       ATGACTTCCTGAAGCCACAGATCATCACCCAGCCAGAAACCACCATGGCTATGGTGGGCAAGGACATC       CGGTTTACATGCTCAGCAGCCAGCAGCAGCAGCTCCCCCATGACCTTTGCCTGGAAGAAAGACAATGA       AGTCCTGACCAATGCAGACATGGAGAACTTTGTCCACGTCCACGCGCAGGACGGGGAAGTGATGGAGT       ACACCACCATCCTGCACCTCCGTCAGGTCACTTTCGGGCACGAGGGCCGCTACCAATGTGTCATCACC       AACCACTTTGGCTCCACCTATTCACATAAGGCCAGGCTCACCGTGAATGTGTTGCCATCATTCACCAA       AACGCCCCACGACATAACCATCCGGACCACCACCATGGCCCGCCTCGAATGTGCTGCCACAGGTCACC       CAAACCCTCAGATTGCCTGGCAGAAGGATGGAGGCACGGATTTCCCCGCTGCCCGTGAGCGACGCATG       CATGTCATGCCGGATGACGACGTGTTTTTCATCACTGATGTGAAAATAGATGACGCAGGGGTTTACAG       CTGTACTGCTCAGAACTCAGCCGGTTCTATTTCAGCTAATGCCACCCTGACTGTCCTAGAGACCCCAT       CCTTGGTGGTCCCCTTGGAAGACCGTGTGGTATCTGTGGGAGAAACAGTGGCCCTCCAATGCAAAGCC       ACGGGGAACCCTCCGCCCCGCATCACCTGGTTCAAGGGGGACCGCCCGCTGAGCCTCACTGAGCGGCA       CCACCTGACCCCTGACAACCAGCTCCTGGTGGTTCAGAACGTGGTGGCAGAGGATGCGGGCCGATATA       CCTGTGAGATGTCCAACACCCTGGGCACGGAGCGAGCTCACAGCCAGCTGAGCGTCCTGCCCGCAGCA       GGCTGCAGGAAGGATGGGACCACGGTAGGCATCTTCACCATTGCTGTCGTGAGCAGCATCGTCCTGAC       GTCACTGGTCTGGGTGTGCATCATCTACCAGACCAGGAAGAAGAGTGAAGAGTACAGTGTCACCAACA       CAGATGAAACCGTCGTGCCACCAGATGTTCCAAGCTACCTCTCTTCTCAGGGGACCCTTTCTGACCGA       CAAGAAACCGTGGTCAGGACCGAGGGTGGCCCTCAGGCCAATGGGCACATTGAGAGCAATGGTGTGTG       TCCAAGAGATGCAAGCCACTTTCCAGAGCCCGACACTCACAGCGTTGCCTGCAGGCAGCCAAAGCTCT       GTGCTGGGTCTGCGTATCACAAAGAGCCGTGGAAAGCGATGGAGAAAGCTGAAGGGACACCTGGGCCA       CATAAGATGGAACACGGTGGCCGGGTCGTATGCAGTGACTGCAACACCGAAGTGGACTGTTACTCCAG       GGGACAAGCCTTCCACCCCCAGCCTGTGTCCAGAGACAGCGCACAGCCAAGTGCGCCAAATGGCCCGG       AGCCGGGTGGGAGTGACCAAGAGCATTCTCCACATCACCAGTGCAGCAGGACTGCCGCTGGGTCCTGC       CCCGAGTGCCAAGGGTCGCTCTACCCCAGTAACCACGATAGAATGCTGACGGCTGTGAAGAAAAAGCC       AATGGCATCTCTAGATGGGAAAGGGGATTCTTCCTGGACTTTAGCAAGGTTGTATCACCCGGACTCCA       CAGAGCTACAGCCTGCATCTTCATTAACTTCAGGCAGTCCAGAGCGCGCGGAAGCCCAGTACTTGCTT       GTTTCCAATGGCCACCTCCCCAAAGCATGTGACGCCAGTCCCGAGTCCACGCCACTGACAGGACAGCT       CCCCGGGAAACAGAGGGTGCCACTGCTGTTGGCACCAAAAAGC TAG   GTTTTGTCTACCTCAGTTCTTG           TCATACCAATCTCTACGGGAAAGAGAGGTAGGAGAGGCTGCGAGGAAGCTTGGGTTCAAGCGTCACTC                   ATCTGTACATAGTTGTAACTCCCATGTGGAGTATCAGTCGCTCACAGGACTTGGATCTGAAGCACAGT           AAACGCAAGAGGGGATTTGTGTACAAAAGGCAAAAAAAAGTATTTGATATCATTGTACATAAGAGTTT           TCAGAGATTTCATATATATCTTTTACAGAGGCTATTTTAATCTTTAGTGCATGGTTAACAGAAAAAAA           TTATACAATTTTGACAATATTATTTTTCGTATCAGGTTGCTGTTTAATTTTGGAGGGGGTGGGGAAAT           AGTTCTGGTGCCTTAACGCATGGCTGGAATTTATAGAGGCTACAACCACATTTGTTCACAGGAGTTTT           TGGTGCGGGGTGGGAAGGATGGAAGGCCTTGGATTTATATTGCACTTCATAGACCCCTAGGCTGCTGT           GCGGTGGGACTCCACATGCGCCGGAAGGAGCTTCAGGTGAGCACTGCTCATGTGTGGATGCCCCTGCA           ACAGGCTTCCCTGTCTGTAGAGCCAGGGGTGCAAGTGCCATCCACACTTGCAGTGAATGGCTTTTCCT           TTTAGGTTTAAGTCCTGTCTGTCTGTAAGGCGTAGAATCTGTCCGTCTGTAAGGCGTAGAATGAGGGT           TGTTAATCCATCACAAGCAAAAGGTCAGAACAGTTAAACACTGCCTTTCCTCCTCCTCTTATTTTATG           ATAAAAGCAAATGTGGCCTTCTCAGTATCATTCGATTGCTATTTGAGACTTTTAAATTAAGGTAAAGG           CTGCTGGTGTTGGTACCTGTGGATTTTTCTATACTGATGTTTTCGTTTTGCCAATATAATGAGTATTA           CATTGGCCTTGGGGGACAGAAAGGAGGAAGTTCTGACTTTTCAGGGCTACCTTATTTCTACTAAGGAC           CCAGAGCAGGCCTGTCCATGCCATTCCTTCGCACAGATGAAACTGAGCTGGGACTGGAAAGGACAGCC           CTTGACCTGGGTTCTGGGTATAATTTGCACTTTTGAGACTGGTAGCTAACCATCTTATGAGTGCCAAT           GTGTCATTTAGTAAAACTTAAATAGAAACAAGGTCCTTCAAATGTTCCTTTGGCCAAAAGCTGAAGGG           AGTTACTGAGAAAATAGTTAACAATTACTGTCAGGTGTCATCACTGTTCAAAAGGTAAGCACATTTAG           AATTTTGTTCTTGACAGTTAACTGACTAATCTTACTTCCACAAAATATGTGAATTTGCTGCTTCTGAG           AGGCAATGTGAAAGAGGGAGTATTACTTTTATGTACAAAGTTATTTATTTATAGAAATTTTGGTACAG           TGTACATTGAAAACCATGTAAAATATTGAAGTGTCTAACAAATGGCATTGAAGTGTCTTTAATAAAGG           TTCATTTATAAATGTCAGTATAGTTGGTGGTCCTTCTTTTACAAACGCAGTCATTCTGCCTTTAATTA           TCTTCCCCCAAAAAAGAAAAAAAAAATAGGCGAAGCAAAATCACATACTGTTTGTTTGCTCCAGGGCA           GACAACACTGCTAGATTCCTGACATTTTGTTTTGAATTTTTCTACACCTGGAGCTTGTTAGTCAAGGT           CTAAAATCCCTAAGTGTGGTGACCTTTCCATTTCATCCTGCCTTTTCAAAGCTGGCCCAGGCCCTCCT           TTCAGTCTGACATGAGAATGGCGAGAATGGCTCACCCACCGTGCCCTCCTGCACGAAGCCAG           CTGGGCC                                           NOV51b, CG59534-01   SEQ ID NO:1086   1077 aa   MW at 117735.2 kD           Protein Sequence                     MRWDLAVLPRLVLISWAQVILLPWPAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEID           PAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNIT       EVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNR       NRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKNHVLHLEYNSLVEVNSGSLYGLTALHQL       HLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRS       LRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFD       AFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDF       LKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTT       ILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHPNP       QIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLV       VPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCE       MSNTLGTERAHSQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDE       TVVPPDVPSYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAG       SAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPSAPNGPEPG       GSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGDSSWTLARLYHPDSTEL       QPASSLTSGSPERAEAQYLLVSNGHLPKACDASPESTPLTGQLPGKQRVPLLLAPKS                                     NOV51c, CG59534-02   SEQ ID NO:1087   4762 bp           DNA Sequence   ORF Start: ATG at 15   ORF Stop: TAG at 3294                       GCGCTCCAGACAAG   ATG   GCGCGGCCGGTCCGGGGAGGGCTCGGGGCCCCGCGCCGCTCGCCTTGCCTT             CTCCTTCTCTGGCTGGTTTTGGTTCGGCTGGAGCCGGTGACCGCCGCGGCCGGCCCGCGGGCGCCCTG       CGCGGCCGCCTGCACTTGCGCTGGGGACTCGCTGGACTGCGGTGGGCGCGGGCTGGCTGCGTTGCCCG       GGGACCTGCCCTCCTGGACGCGGAGCCTAAACCTGAGTTACAACAAACTCTCTGAGATTGACCCTGCT       GGTTTTGAGGACTTGCCGAACCTACAGGAAGTGTACCTCAATAATAATGAGTTGACAGCGGTACCATC       CCTGGGCGCTGCTTCATCACATGTCGTCTCTCTCTTTCTGCAGCACAACAAGATTCGCAGCGTGGAGG       GGAGCCAGCTGAAGGCCTACCTTTCCTTAGAAGTGTTAGATCTGAGTTTGAACAACATCACGGAAGTG       CGGAACACCTGCTTTCCACACGGACCGCCTATAAAGGAGCTCAACCTGGCAGGCAATCGGATTGGCAC       CCTGGAGTTGGGAGCATTTGATGGTCTGTCACGGTCGCTGCTAACTCTTCGCCTGAGCAAAAACAGGA       TCACCCAGCTTCCTGTAAGAGCATTCAAGCTACCCAGGCTGACACAACTGGACCTCAATCGGAACAGG       ATTCGGCTGATAGAGGGCCTCACCTTCCAGGGGCTCAACAGCTTGGAGGTGCTGAAGCTTCAGCGAAA       CAACATCAGCAAACTGACAGATGGGGCCTTCTGGGGACTGTCCAAGATGCATGTGCTGCACCTGGAGT       ACAACAGCCTGGTAGAAGTGAACAGCGGCTCGCTCTACGGCCTCACGGCCCTGCATCAGCTCCACCTC       AGCAACAATTCCATCGCTCGCATTCACCGCAAGGGCTGGAGCTTCTGCCAGAAGCTGCATGAGTTGGT       CCTGTCCTTCAACAACCTGACACGGCTGGACGAGGAGAGCCTGGCCGAGCTGAGCAGCCTGAGTGTCC       TGCGTCTCAGCCACAATTCCATCAGCCACATTGCGGAGGGTGCCTTCAAGGGACTCAGGAGCCTGCGA       GTCTTGGATCTGGACCATAACGAGATTTCGGGCACAATAGAGGACACGAGCGGCGCCTTCTCAGGGCT       CGACAGCCTCAGCAAGCTGACTCTGTTTGGAAACAAGATCAAGTCTGTGGCTAAGAGAGCATTCTCGG       GGCTGGAAGGCCTGGAGCACCTGAACCTTGGAGGGAATGCGATCAGATCTGTCCAGTTTGATGCCTTT       GTGAAGATGAAGAATCTTAAAGAGCTCCATATCAGCAGCGACAGCTTCCTGTGTGACTGCCAGCTGAA       GTGGCTGCCCCCGTGGCTAATTGGCAGGATGCTGCAGGCCTTTGTGACAGCCACCTGTGCCCACCCAG       AATCACTGAAGGGTCAGAGCATTTTCTCTGTGCCACCAGAGAGTTTCGTGTGCGATGACTTCCTGAAG       CCACAGATCATCACCCAGCCAGAAACCACCATGGCTATGGTGGGCAAGGACATCCGGTTTACATGCTC       AGCAGCCAGCAGCAGCAGCTCCCCCATGACCTTTGCCTGGAAGAAAGACAATGAAGTCCTGACCAATG       CAGACATGGAGAACTTTGTCCACGTCCACGCGCAGGACGGGGAAGTGATGGAGTACACCACCATCCTG       CACCTCCGTCAGGTCACTTTCGGGCACGAGGGCCGCTACCAATGTGTCATCACCAACCACTTTGGCTC       CACCTATTCACATAAGGCCAGGCTCACCGTGAATGTGTTGCCATCATTCACCAAAACGCCCCACGACA       TAACCATCCGGACCACCACCGTGGCCCGCCTCGAATGTGCTGCCACAGGTCACCCAAACCCTCAGATT       GCCTGGCAGAAGGATGGAGGCACGGATTTCCCCGCTGCCCGTGAGCGACGCATGCATGTCATGCCGGA       TGACGACGTGTTTTTCATCACTGATGTGAAAATAGATGACGCAGGGGTTTACAGCTGTACTGCTCAGA       ACTCAGCCGGTTCTATTTCAGCTAATGCCACCCTGACTGTCCTAGAGACCCCATCCTTGGTGGTCCCC       TTGGAAGACCGTGTGGTATCTGTGGGAGAAACAGTGGCCCTCCAATGCAAAGCCACGGGGAACCCTCC       GCCCCGCATCACCTGGTTCAAGGGGGACCGCCCGCTGAGCCTCACTGAGCGGCACCACCTGACCCCTG       ACAACCAGCTCCTGGTGGTTCAGAACGTGGTGGCAGAGGATGCGGGCCGATATACCTGTGAGATGTCC       AACACCCTGGGCACGGAGCGAGCTCACAGCCAGCTGAGCGTCCTGCCCGCAGCAGGCTGCAGGAAGGA       TGGGACCACGGTAGGCATCTTCACCATTGCTGTCGTGAGCAGCATCGTCCTGACGTCACTGGTCTGGG       TGTGCATCATCTACCAGACCAGGAAGAAGAGTGAAGAGTACAGTGTCACCAACACAGATGAAACCGTC       GTGCCACCAGATGTTCCAAGCTACCTCTCTTCTCAGGGGACCCTTTCTGACCGACAAGAAACCGTGGT       CAGGACCGAGGGTGGCCCTCAGGCCAATGGGCACATTGAGAGCAATGGTGTGTGTCCAAGAGATGCAA       GCCACTTTCCAGAGCCCGACACTCACAGCGTTGCCTGCAGGCAGCCAAAGCTCTGTGCTGGGTCTGCG       TATCACAAAGAGCCGTGGAAAGCGATGGAGAAAGCTGAAGGGACACCTGGGCCACATAAGATGGAACA       CGGTGGCCGGGTCGTATGCAGTGACTGCAACACCGAAGTGGACTGTTACTCCAGGGGACAAGCCTTCC       ACCCCCAGCCTGTGTCCAGAGACAGCGCACAGCCAAGTGCGCCAAATGGCCCGGAGCCGGGTGGGAGT       GACCAAGAGCATTCTCCACATCACCAGTGCAGCAGGACTGCCGCTGGGTCCTGCCCCGAGTGCCAAGG       GTCGCTCTACCCCAGTAACCACGATAGAATGCTGACGGCTGTGAAGAAAAAGCCAATGGCATCTCTAG       ATGGGAAAGGGGATTCTTCCTGGACTTTAGCAAGGTTGTATCACCCGGACTCCACAGAGCTACAGCCT       GCATCTTCATTAACTTCAGGCAGTCCAGAGCGCGCGGAAGCCCAGTACTTGCTTGTTTCCAATGGCCA       CCTCCCCAAAGCATGTGACGCCAGTCCCGAGTCCACGCCACTGACAGGACAGCTCCCCGGGAAACAGA       GGGTGCCACTGCTGTTGGCACCAAAAAGC TAG   GTTTTGTCTACCTCAGTTCTTGTCATACCAATCTCT                   ACGGGAAAGAGAGGTAGGAGAGGCTGCGAGGAAGCTTGGGTTCAAGCGTCACTCATCTGTACATAGTT           GTAACTCCCATGTGGAGTATCAGTCGCTCACAGGACTTGGATCTGAAGCACAGTAAACGCAAGAGGGG           ATTTGTGTACAAAAGGCAAAAAAAGTATTTGATATCATTGTACATAAGAGTTTTCAGAGATTTCATAT           ATATCTTTTACAGAGGCTATTTTAATCTTTAGTGCATGGTTAACAGAAAAAAATTATACAATTTTGAC           AATATTATTTTTCGTATCAGGTTGCTGTTTAATTTTGGAGGGGGTGGGGAAATAGTTCTGGTGCCTTA           ACGCATGGCTGGAATTTATAGAGGCTACAACCACATTTGTTCACAGGAGTTTTTGGTGCGGGGTGGGA           AGGATGGAAGGCCTTGGATTTATATTGCACTTCATAGACCCCTAGGCTGCTGTGCGGTGGGACTCCAC           ATGCGCCGGAAGGAGCTTCAGGTGAGCACTGCTCATGTGTGGATGCCCCTGCAACAGGCTTCCCTGTC           TGTAGAGCCAGGGGTGCAAGTGCCATCCACACTTGCAGTGAATGGCTTTTCCTTTTAGGTTTAAGTCC           TGTCTGTCTGTAAGGCGTAGAATCTGTCCGTCTGTAAGGCGTAGAATGAGGGTTGTTAATCCATCACA           AGCAAAAGGTCAGAACAGTTAAACACTGCCTTTCCTCCTCCTCTTATTTTATGATAAAAGCAAATGTG           GCCTTCTCAGTATCATTCGATTGCTATTTGAGACTTTTAAATTAAGGTAAAGGCTGCTGGTGTTGGTA           CCTGTGGATTTTTCTATACTGATGTTTTCGTTTTGCCAATATAATGAGTATTACATTGGCCTTGGGGG           ACAGAAAGGAGGAAGTTCTGACTTTTCAGGGCTACCTTATTTCTACTAAGGACCCAGAGCAGGCCTGT           CCATGCCATTCCTTCGCACAGATGAAACTGAGCTGGGACTGGAAAGGACAGCCCTTGACCTGGGTTCT           GGGTATAATTTGCACTTTTGAGACTGGTAGCTAACCATCTTATGAGTGCCAATGTGTCATTTAGTAAA           ACTTAAATAGAAACAAGGTCCTTCAAATGTTCCTTTGGCCAAAAGCTGAAGGGAGTTACTGAGAAAAT           AGTTAACAATTACTGTCAGGTGTCATCACTGTTCAAAAGGTAAGCACATTTAGAATTTTGTTCTTGAC           AGTTAACTGACTAATCTTACTTCCACAAAATATGTGAATTTGCTGCTTCTGAGAGGCAATGTGAAAGA           GGGAGTATTACTTTTATGTACAAAGTTATTTATTTATAGAAATTTTGGTACAGTGTACATTGAAAACC           ATGTAAAATATTGAAGTGTCTAACAAATGGCATTGAAGTGTCTTTAATAAAGGTTCATTTAT           AAATGTCA                                           NOV51c, CG59534-02   SEQ ID NO:1088   1093 aa   MW at 119051.7 kD           Protein Sequence                     MARPVRGGLGAPRRSPCLLLLWLVLVRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPS           WTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLK       AYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLP       VEAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLV       EVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSH       NSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGL       EHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKG       QSIFSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMEN       FVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKAPLTVNVLPSFTKTPHDITIRT       TTVARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGS       ISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLL       VVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIY       QTRKKSEEYSVTNTDETVVPPDVPSYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPE       PDTHSVACRQPKLCAGSAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPV       SRDSAQPSAPNGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGD       SSWTLARLYHPDSTELQPASSLTSGSPERAEAQYLLVSNGHLPKACDASPESTPLTGQLPGKQRVPLL       ILAPKS                                     NOV51d, SNP13377255 of   SEQ ID NO:1089   3333 bp           CG59534-03, DNA Sequence   ORF Start: ATG at 15   ORF Stop: TAG at 3219           SNP Pos: 1912   SNP Change: T to C                       GCGCTCCAGACAAG   ATG GCGCGGCCGGTCCGGGGAGGGCTCGGGGCCCCGCGCCGCTCGCCTTGCCTT           CTCCTTCTCTGGCTGGTTTTGGTTCGGCTGGAGCCGGTGACCGCCGCGGCCGGCCCGCGGGCGCCCTG       CGCGGCCGCCTGCACTTGCGCTGGGGACTCGCTGGACTGCGGTGGGCGCGGGCTGGCTGCGTTGCCCG       GGGACCTGCCCTCCTGGACGCGGAGCCTAAACCTGAGTTACAACAAACTCTCTGAGATTGACCCTGCT       GGTTTTGAGGACTTGCCGAACCTACAGGAAGTGCAGCACAACAAGATTCGCAGCGTGGAGGGGAGCCA       GCTGAAGGCCTACCTTTCCTTAGAAGTGTTAGATCTGAGTTTGAACAACATCACGGAAGTGCGGAACA       CCTGCTTTCCACACGGACCGCCTATAAAGGAGCTCAACCTGGCAGGCAATCGGATTGGCACCCTGGAG       TTGGGAGCATTTGATGGTCTGTCACGGTCGCTGCTAACTCTTCGCCTGAGCAAAAACAGGATCACCCA       GCTTCCTGTAAGAGCATTCAAGCTACCCAGGCTGACACAACTGGACCTCAATCGGAACAGGATTCGGC       TGATAGAGGGCCTCACCTTCCAGGGGCTCAACAGCTTGGAGGTGCTGAAGCTTCAGCGAAACAACATC       AGCAAACTGACAGATGGGGCCTTCTGGGGACTGTCCAAGATGCATGTGCTGCACCTGGAGTACAACAG       CCTGGTAGAAGTGAACAGCGGCTCGCTCTACGGCCTCACGGCCCTGCATCAGCTCCACCTCAGCAACA       ATTCCATCGCTCGCATTCACCGCAAGGGCTGGAGCTTCTGCCAGAAGCTGCATGAGTTGGTCCTGTCC       TTCAACAACCTGACACGGCTGGACGAGGAGAGCCTGGCCGAGCTGAGCAGCCTGAGTGTCCTGCGTCT       CAGCCACAATTCCATCAGCCACATTGCGGAGGGTGCCTTCAAGGGACTCAGGAGCCTGCGAGTCTTGG       ATCTGGACCATAACGAGATTTCGGGCACAATAGAGGACACGAGCGGCGCCTTCTCAGGGCTCGACAGC       CTCAGCAAGCTGACTCTGTTTGGAAACAAGATCAAGTCTGTGGCTAAGAGAGCATTCTCGGGGCTGGA       AGGCCTGGAGCACCTGAACCTTGGAGGGAATGCGATCAGATCTGTCCAGTTTGATGCCTTTGTGAAGA       TGAAGAATCTTAAAGAGCTCCATATCAGCAGCGACAGCTTCCTGTGTGACTGCCAGCTGAAGTGGCTG       CCCCCGTGGCTAATTGGCAGGATGCTGCAGGCCTTTGTGACAGCCACCTGTGCCCACCCAGAATCACT       GAAGGGTCAGAGCATTTTCTCTGTGCCACCAGAGAGTTTCGTGTGCGATGACTTCCTGAAGCCACAGA       TCATCACCCAGCCAGAAACCACCATGGCTATGGTGGGCAAGGACATCCGGTTTACATGCTCAGCAGCC       AGCAGCAGCAGCTCCCCCATGACCTTTGCCTGGAAGAAAGACAATGAAGTCCTGACCAATGCAGACAT       GGAGAACTTTGTCCACGTCCACGCGCAGGACGGGGAAGTGATGGAGTACACCACCATCCTGCACCTCC       GTCAGGTCACTTTCGGGCACGAGGGCCGCTACCAATGTGTCATCACCAACCACTTTGGCTCCACCTAT       TCACATAAGGCCAGGCTCACCGTGAATGTGTTGCCATCATTCACCAAAACGCCCCACGACATAACCAT       CCGGACCACCACCGTGGCCCGCCTCGAATGTGCTGCCACAGGTCACCCAAACCCTCAGATTGCCTGGC       AGAAGGATGGAGGCACGGATTTCCCCGCTGCCCGTGAGCGACGCATGCATGTCATGCCGGATGACGAC       GTGTTTTCCATCACTGATGTGAAAATAGATGACGCAGGGGTTTACAGCTGTACTGCTCAGAACTCAGC       CGGTTCTATTTCAGCTAATGCCACCCTGACTGTCCTAGAGACCCCATCCTTGGTGGTCCCCTTGGAAG       ACCGTGTGGTATCTGTGGGAGAAACAGTGGCCCTCCAATGCAAAGCCACGGGGAACCCTCCGCCCCGC       ATCACCTGGTTCAAGGGGGACCGCCCGCTGAGCCTCACTGAGCGGCACCACCTGACCCCTGACAACCA       GCTCCTGGTGGTTCAGAACGTGGTGGCAGAGGATGCGGGCCGATATACCTGTGAGATGTCCAACACCC       TGGGCACGGAGCGAGCTCACAGCCAGCTGAGCGTCCTGCCCGCAGCAGGCTGCAGGAAGGATGGGACC       ACGGTAGGCATCTTCACCATTGCTGTCGTGAGCAGCATCGTCCTGACGTCACTGGTCTGGGTGTGCAT       CATCTACCAGACCAGGAAGAAGAGTGAAGAGTACAGTGTCACCAACACAGATGAAACCGTCGTGCCAC       CAGATGTTCCAAGCTACCTCTCTTCTCAGGGGACCCTTTCTGACCGACAAGAAACCGTGGTCAGGACC       GAGGGTGGCCCTCAGGCCAATGGGCACATTGAGAGCAATGGTGTGTGTCCAAGAGATGCAAGCCACTT       TCCAGAGCCCGACACTCACAGCGTTGCCTGCAGGCAGCCAAAGCTCTGTGCTGGGTCTGCGTATCACA       AAGAGCCGTGGAAAGCGATGGAGAAAGCTGAAGGGACACCTGGGCCACATAAGATGGAACACGGTGGC       CGGGTCGTATGCAGTGACTGCAACACCGAAGTGGACTGTTACTCCAGGGGACAAGCCTTCCACCCCCA       GCCTGTGTCCAGAGACAGCGCACAGCCAAGTGCGCCAAATGGCCCGGAGCCGGGTGGGAGTGACCAAG       AGCATTCTCCACATCACCAGTGCAGCAGGACTGCCGCTGGGTCCTGCCCCGAGTGCCAAGGGTCGCTC       TACCCCAGTAACCACGATAGAATGCTGACGGCTGTGAAGAAAAAGCCAATGGCATCTCTAGATGGGAA       AGGGGATTCTTCCTGGACTTTAGCAAGGTTGTATCACCCGGACTCCACAGAGCTACAGCCTGCATCTT       CATTAACTTCAGGCAGTCCAGAGCGCGCGGAAGCCCAGTACTTGCTTGTTTCCAATGGCCACCTCCCC       AAAGCATGTGACGCCAGTCCCGAGTCCACGCCACTGACAGGACAGCTCCCCGGGAAACAGAGGGTGCC       ACTGCTGTTGGCACCAAAAAGC TAG   GTTTTGTCTACCTCAGTTCTTGTCATACCAATCTCTACGGGAA           AGAGAGGTAGGAGAGGCTGCGAGGAAGCTTGGGTTCAAGCGTCACTCATCTGTACATAGTTGT           AACTCC                                           NOV51d, SNP13377255 of   SEQ ID NO:1090   1068 aa   MW at 116392.7 kD           CG59534-03, Protein Sequence   SNP Pos: 633       SNP Change: Phe to Ser                     MARPVRGGLGAPRRSPCLLLLWLVLVRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPS           WTRSLNLSYNKLSEIDPAGFEDLPNLQEVQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPH       GPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGL       TFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIAR       IHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHN       EISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLK       ELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQP       ETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTF       GHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTVARLECAATGHPNPQIAWQKDGG       TDFPAARERRMHVMPDDDVF   S   ITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVS       VGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTER       AHSQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPS       YLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAGSAYHKEPWK       AMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPSAPNGPEPGGSDQEHSPH       HQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGDSSWTLARLYHPDSTELQPASSLTSG       SPERAEAQYLLVSNGHLPKACDASPESTPLTGQLPGKQRVPLLLAPKS                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 51B.  
               TABLE 51B                       Comparison of the NOV51 protein sequences.                                                NOV51a   MARPVRGGLGAPRRSPCLLLLWLVLVRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLA   (SEQ ID NO:1084)                   NOV51b   ----MRWDLAVLPR--------LVLISWAQVILLPWP----AAACTCAGDSLDCGGRGLA   (SEQ ID NO:1086)               NOV51c   MARPVRGGLGAPRRSPCLLLLWLVLVRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLA   (SEQ ID NO:1088)               NOV51a   ALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLGEV-----------------------               NOV51b   ALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSL               NOV51c   ALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSL               NOV51a   --QHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLEL               NOV51b   FLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLEL               NOV51c   FLQHNKIRSVEGSQLKAYLSLEVLDLSLNNTTEVRNTCFPHGPPIKELNLAGNRIGTLEL               NOV51a   GAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNPNRIRLIEGLTFQGLNSLEVL               NOV51b   GAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVL               NOV51c   GAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVL               NOV51a   KLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHR               NOV51b   KLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHR               NOV51c   KLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHR               NOV51a   KGWSFCQKLHELVLSFNNLTRLDEESIAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVL               NOV51b   KGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVL               NOV51c   KGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVL               NOV51a   DLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRS               NOV51b   DLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRS               NOV51c   DLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRS               NOV51a   VQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIF               NOV51b   VQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIF               NOV51c   VQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIF               NOV51a   SVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNA               NOV51b   SVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNA               NOV51c   SVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNA               NOV51a   DMENFVNVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPS               NOV51b   DMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPS               NOV51c   DMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPS               NOV51a   FTKTPHDITIRTTTVARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFIT               NOV51b   FTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFIT               NOV51c   FTKTPHDITIRTTTVARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFIT               NOV51a   DVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNP               NOV51b   DVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNP               NOV51c   DVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNP               NOV51a   PPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV               NOV51b   PPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV               NOV51c   PPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV               NOV51a   LPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVP               NOV51b   LPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVP               NOV51c   LPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVP               NOV51a   SYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAG               NOV51b   SYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAG               NOV51c   SYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAG               NOV51a   SAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPS               NOV51b   SAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPS               NOV51c   SAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPS               NOV51a   APNGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGD               NOV51b   APNGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGD               NOV51c   APNGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGD               NOV51a   SSWTLARLYHPDSTELQPASSLTSGSPERAEAQYLLVSNGHLPKACDASPESTPLTGQLP               NOV51b   SSWTLARLYHPDSTELQPASSLTSGSPERAEAQYLLVSNGHLPKACDASPESTPLTGQLP               NOV51c   SSWTLARLYHPDSTELQPASSLTSGSPERAEAQYLLVSNGHLPKACDASPESTPLTGQLP               NOV51a   GKQRVPLLIAPKS               NOV51b   GKQRVPLLLAPKS               NOV51c   GKQRVPLLLAPKS                  
 
      Further analysis of the NOV51a protein yielded the following properties shown in Table 51C.  
               TABLE 51C                       Protein Sequence Properties NOV51a                                        SignalP analysis:   Cleavage site between residues 36 and 37       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 6; pos.chg 2; neg.chg 0           H-region:   length 6; peak value −9.10           PSG score:   −13.50                         GvH: von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −0.07           possible cleavage site: between 33 and 34                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 2                                 INTEGRAL   Likelihood =   Transmembrane 17-33               −2.87           INTEGRAL   Likelihood =   Transmembrane 773-789               −8.23                             PERIPHERAL   Likelihood = 3.76 (at 656)                         ALOM score: −8.23 (number of TMSs: 2)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 24           Charge difference: −4.0 C(1.0)-N(5.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 3a                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   5   Hyd Moment(75):   4.80           Hyd Moment(95):   12.52   G content:   3           D/E content:   1   S/T content:   1                         Score: −0.99           Gavel: prediction of cleavage sites for mitochondrial preseq           R-2 motif at 48 PRA|PC                 NUCDISC: discrimination of nuclear localization signals                         pat4: KKKP (4) at 983           pat7: PAARERR (3) at 616           bipartite: none           content of basic residues: 9.7%           NLS Score: 0.04           KDEL: ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: ARPV           KKXX-like motif in the C-terminus: LAPK                 SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs:                         Leucine zipper pattern (PS00029): *** found ***            LDCGGRGLAALPGDLPSWTRSL at 52                 none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 70.6       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         34.8%: nuclear           30.4%: mitochondrial           21.7%: endoplasmic reticulum            4.3%: plasma membrane            4.3%: cytoplasmic            4.3%: peroxisomal                 &gt;&gt; prediction for CG59534-03 is nuc (k = 23)                  
 
      A search of the NOV51a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 51D.  
               TABLE 51D                          Geneseq Results for NOV51a                                         NOV51a   Identities/           Geneseq   Protein/Organism/Length   Residues/Match   Similarities for the   Expect       Identifier   [Patent #, Date]   Residues   Matched Region   Value               ABG69660   Human secreted protein SCEP-40 -   1 . . . 1068   1065/1093 (97%)   0.0             Homo sapiens , 1093 aa.   1 . . . 1093   1068/1093 (97%)           [WO200248337-A2, 20-JUN-2002]       AAY08008   Human HLIG-1 protein -  Homo sapiens ,   1 . . . 1068   1053/1101 (95%)   0.0           1101 aa. [EP913472-A2,   1 . . . 1101   1062/1101 (95%)           06-MAY-1999]       ABG69674   Human secreted protein SCEP-54 -   1 . . . 1068   1042/1093 (95%)   0.0             Homo sapiens , 1070 aa.   1 . . . 1070   1045/1093 (95%)           [WO200248337-A2, 20-JUN-2002]       ABP70116   Human NOV30a -  Homo sapiens ,   42 . . . 1068    1026/1052 (97%)   0.0           1077 aa. [WO200272771-A2,   26 . . . 1077    1027/1052 (97%)           19-SEP-2002]       AAY97833   Murine LIG-1 protein -  Mus  sp, 1091   1 . . . 1068    887/1102 (80%)   0.0           aa. [JP2000093043-A, 04-APR-2000]   1 . . . 1091    945/1102 (85%)                  
 
      In a BLAST search of public sequence databases, the NOV51 a protein was found to have homology to the proteins shown in the BLASTP data in Table 51E.  
               TABLE 51E                          Public BLASTP Results for NOV51a                                 Protein       NOV51a   Identities/           Accession       Residues/Match   Similarities for the   Expect       Number   Protein/Organism/Length   Residues   Matched Portion   Value                                             Q96JA1   Membrane glycoprotein LIG-1 -   1 . . . 1068   1068/1093   (97%)   0.0             Homo sapiens  (Human), 1093 aa.   1 . . . 1093   1068/1093   (97%)           Q9BYB8   Membrane glycoprotein LIG-1 -   1 . . . 1068   1064/1094   (97%)   0.0             Homo sapiens  (Human), 1094 aa.   1 . . . 1094   1068/1094   (97%)       P70193   Membrane glycoprotein -   1 . . . 1068   887/1102   (80%)   0.0             Mus musculus  (Mouse), 1091 aa.   1 . . . 1091   945/1102   (85%)       Q9UFI4   Hypothetical protein -   586 . . . 1068   481/483   (99%)   0.0             Homo sapiens  (Human), 483 aa   1 . . . 483   481/483   (99%)           (fragment).       O94898   Hypothetical protein KIAA0806 -   41 . . . 993   491/1002   (49%)   0.0             Homo sapiens  (Human), 1065 aa.   43 . . . 991   624/1002   (62%)                  
 
      PFam analysis predicts that the NOV51a protein contains the domains shown in the Table 51F.  
               TABLE 51F                          Domain Analysis of NOV51a                                                     Identities/                           Similarities           Pfam   NOV51a       for the   Expect           Domain   Match Region       Matched Region   Value                                                     LRRNT   40 . . . 67   17/35   (49%)   0.0012                   20/35   (57%)           LRR   211 . . . 234   10/25   (40%)   0.063                   21/25   (84%)           LRR   283 . . . 306   11/25   (44%)   0.16                   20/25   (80%)           LRR   307 . . . 330   9/25   (36%)   0.0016                   23/25   (92%)           LRR   382 . . . 405   9/25   (36%)   0.18                   18/25   (72%)           LRRCT   415 . . . 465   22/54   (41%)   1.6e−13                   42/54   (78%)           ig   484 . . . 554   13/72   (18%)    2e−05                   50/72   (69%)           ig   588 . . . 649   13/65   (20%)   0.025                   43/65   (66%)           ig   682 . . . 740   19/62   (31%)   1.4e−08                   45/62   (73%)                      
 
     Example 52  
      The NOV52 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 52A.  
               TABLE 52A                       NOV52 Sequence Analysis                                                NOV52a, CG59584-03   SEQ ID NO:1091   4994 bp           DNA Sequence   ORF Start: ATG at 36   ORF Stop: TGA at 4815                       CCTGGACCTAATACCCCTTCTTCCTAAAGCACAAA   ATG ATTAAATTGCTTAATCCAGACAACTCTCCA           ATCCCAAATGAAGTTGTTCAGTTGCATCTGAAGGACAAAATCGTGGGAAACTACACCACAGATGTAAA       TGGCATCGCTCAGTTTTTCTTGGACACATATACGTTTACATACCCAAATATCACTTTGAAAGCAGCCT       ACAAGGCCAATGAAAATTGCCAGGCTCATGGCTGGGTGTTGCCTCAATACCCTCAGCCCGAGTACTTT       GCATATCGATTTTACTCCAAGATGAATAGCTTCCTAAAGATTGTCCAAGAGATGGAAGAACTGAGATG       CAACCAGCAGAAGAGGGTGCTAGTGCACTGCATTCTCAATATGGAAGACTTTGAAGACAAAACCTACA       CAGCAGACTTCAATTATTTGGTGATTTCAAAAGGTGTAATCATTCTTCATGGGCAACAGAAAATTGAG       ATCAACGAAAATGGGAGGAAGGGCATATTTTCCATTTCTATAGACATTAACCCTGAATTAGCGCCCTC       AGTAGATATGCTTGTCTATAGCTTGCATCCTGGAGGAGAAATGGTCACTGATAGCACCCAATTCCGAA       TTGAGAAATGCTTCGAAAATCAGGTCAACTTAAATTTTTCTAAAGAAAAAAGTTTACCAGGATCCAAT       ATTGATCTTCAAGTCTCGGCTGCTTCAAACTCTCTTTGTGCTCTTTGGGCTGTAGACCAGAGTGTATT       GCTACTAAGGAATTATGGTCAGCTGTCAGCACAAACTGTGTATAGTCAGCTATATTCCAGGGAACTAC       ATGGCTATTACTTCAGAGGACTTAACTTAGAAGATGGCCTTAAAGTGCCGTGTCTTGAAGATGAACAT       ATCCTTTACAATGGAATTTATTACACACCTGCATGGGCTGACTTTGGAAAAGATGGCTATGACCTTGT       GAAGGATCCTCAAAACAATCGGATTTTTCAAAGGCAAAATGTGACTTCTTTCCGAAATATTACCCAAC       TCTCGTTCCAACTGATTTCAGAACCAATGTTTGGAGATTACTGGATTGTTGTGAAAAGAAACTCAAGG       GAGACAGTGACACACCAATTTGCTGTTAAAAGATATGTGCTGCCCAAGTTTGAAGTTACAGTCAATGC       ACCACAAACAGTAACTATTTCAGATGATGAATTCCAAGTGGATGTATGTGCTAAGTACAACTTTGGCC       AACCTGTGCAAGGGGAAACCCAAATCCGGGTGTGCAGAGAGTATTTTTCTTCAAGCAATTGTGAGAAA       AATGAAAATGAAATATGTGAGCAATTTATTGCACAGTTGGAAAATGGTTGTGTTTCTCAAATTGTAAA       TACAAAAGTCTTCCAACTCTACCGTTCGGGATTGTTCATGACATTTCATGTCGCTGTAATTGTTACAG       AATCTGGGACAGTTATGCAGATCAGCGAGAAGACCTCAGTTTTTATCACTCAATTGCTTGGAACTGTA       AACTTTGAGAACATGGATACATTCTATAGAAGAGGGATTTCTTATTTTGGAACTCTTAAATTTTCGGA       TCCCAATAATGTACCTATGGTGAACAAGTTGTTGCAACTGGAGCTCAATGATGAATTTATAGGAAATT       ACACTACGGATGAGAATGGCGAAGCTCAATTTTCCATTGACACTTCAGACATATTTGATCCAGAGTTC       AACCTAAAAGCCACATATGTTCGACCTGAGAGCTGCTATCTTCCCAGCTGGTTGACGCCTCAGTACTT       GGATGCTCACTTCTTAGTCTCACGCTTTTACTCCCGAACCAACAGCTTCCTGAAGATTGTTCCAGAAC       CAAAGCAGCTTGAATGTAATCAACAGAAGGTTGTTACTGTGCATTACTCCCTAAACAGTGAAGCATAT       GAGGATGATTCCAATGTAAAGTTCTTCTATTTGATGATGGTAAAAGGAGCTATCTTACTCAGTGGACA       AAAGGAAATCAGAAACAAAGCCTGGAATGGAAACTTCTCGTTCCCAATCAGCATCAGTGCTGATCTGG       CTCCTGCAGCCGTCCTGTTTGTCTATACCCTTCACCCCAGTGGGGAAATTGTGGCTGACAGTGTCAGA       TTCCAGGTTGACAAGTGCTTTAAACACAAGGTTAACATAAAGTTCTCTAACGAGCAGGGCTTACCTGG       TTCCAATGCTAGTCTCTGTCTTCAAGCGGCGCCTGTCTTATTCTGTGCCCTCAGGGCTGTGGATAGGA       ATGTCCTTCTACTGAAATCTGAACAACAGCTGTCAGCTGAAAGTGTGTATAACATGGTTCCAAGTATA       GAGCCGTATGGTTATTTCTACCATGGCCTCAATCTTGATGATGGCAAGGAAGACCCTTGCATTCCTCA       GAGGGATATGTTCTACAATGGTTTATATTACACACCTGTAAGCAACTATGGGGATGGAGATATCTATA       ATATTGTCAGGAACATGGGTCTAAAAGTCTTTACCAATCTCCATTACCGAAAACCAGAAAAAATTATG       GTCCAATGCGTAGTGTTCCGTCTAGAATTGCATGTAGCTAGTGGAATCAGAGGGGAGAATGCTGACTA       TGTAGAACAGGCTATAATTCAAACAGTAAGAACAAACTTCCCAGAGACATGGATGTGGGACCTCGTCA       GTGTCGATTCCTCAGGCTCTGCCAATCTTTCGTTCCTCATTCCTGATACGATAACCCAATGGGAGGCA       AGTGGCTTTTGTGTGAATGGTGACGTTGGATTTGGCATTTCCTCTACAACCACTCTAGAAGTCTCCCA       ACCTTTCTTTATTGAGATTGCCTCACCCTTTTCGGTTGTTCAAAATGAACAATTTGATTTGATTGTCA       ATGTCTTCAGCTACCGGAATACATGTGTAGAGATTTCTGTTCAAGTGGAGGAGTCTCAGAATTATGAA       GCAAATATTCATACCTTGAAAATCAATGGCAGTGAGGTTATTCAAGCTGGAGGGAGGAAAACAAACGT       CTGGACTATTATACCTAAGAAATTGGGTAAAGTGAATATCACTGTAGTTGCTGAGTCCAAACAAAGCA       TTAGTAGAGCCTGAAGGTATTGAAAAGGAAAGGACCCAGAGTTTCCTTATCTGTACAGAAGGTGCCAA       CTGTTGTGGGGGATATTCTAGGACTTGCCTTGCAGAATCTGGTTGTTCTCCAAATGCCCTATGGAAGT               GGAGAGCAGAATGCTGCCCTACTAGCATCTGATACTTATGTTCTGGACTATCTGAAATCTACTGAGCA       ACTGACAGAGGAAGTTCAATCTAAGGCTTTCTTTCTCTTATCTAATGGTTATCAAAGGCAATTATCTT       TCAAAAACTCTGATGGTTCCTATAGTGTGTTTTGGCAGCAGAGTCAGAAAGGAAGCATATGGCTCAGT       GCTCTTACTTTTAAGACATTGGAGAGAATGAAAAAATATGTATTCATTGATGAAAATGTTCAAAAACA       GACCTTAATCTGGCTTTCAAGCCAACAGAAAACAAGCGGCTGCTTTAAGAATGATGGCCAGCTTTTCA       ACCACGCCTGGGAGGGTGGAGATGAAGAGGACATTTCACTCACTGCGTATGTTGTTGGGATGTTCTTT       GAAGCTGGGCTCAATTTCACTTTTCCTGCTCTACGAAACGCACTCTTTTGCCTTGAAGCGGCATTGGA       CAGTGGTGTCACTAATGGCTATAATCATGCAATTCTAGCTTATGCTTTTGCCTTAGCTGGAAAAGAGA       AGCAAGTGGAATCTTTACTCCAAACCCTGGATCAATCTGCCCCAAAACTAAATAATGTCATCTACTGG       TGAGAAGAGTTGCTACGTGCTGTTGGCTGTCATTTCCCGGAAAATTCCTGACCTCACCTATGCTAGTA       AGATTGTGCAGTGGCTTGCCCAACGGATGAATTCCCATGGAGGCTTTTCTTCCAACCAGACACCTGAT       GATACTCTGTTCAAATTATATACGGGCCAAAAAGAAAGCTTTCGCTCTAGTTCTGTGGGCTATACACT       GGGAAAAGCAAATGAAAAGAAGGAAAACAGGAGAAATGGGGGTGAAGGATCCAGTGAGATTTTCCAGG       TTAACGGTCATAACCGCCTACTGGTCCAACGTTCAGAAGTAACACAGGCACCTGGAGAATACACAGTA       GATGTGGAAGGACACGGTTGTACATTTATCCAGGCCACCCTTAAGTACAATGTTCTCCTACCTAAGAA       GGCATCTGGATTTTCTCTTTCCTTGGAAATAGTAAAGAACTACTCTTCGACTGCTTTTGACCTCACAG       TGACCCTCAAATACACTGGAATTCGCAATAAATCCAGTATGGTGGTTATAGATGTAAAAATGCTATCA       CAAGAATGACCATGTTCTTTTCTACTTGGAAAATGTAGGTTTTGGTCGAGCAGACAGTTTCCCTTTTT       CTGTTGAGCAGAGCAACCTTGTGTTCAACATTCAGCCAGCCCCAGCCATGGTCTACGATTATTATGAA       AAAGAAGAATATGCCCTAGCTTTTTACAACATCGACAGTAGTTCAGTTTCCGAG TGA   GACAAAGCAAT           TACTAGAAGAGTTGGAGAAGCATTTCTTGTAACAAACTGATTCTTCTGTATCAAACCTGGAAAAAAAT           CATGAACCATCTGACATCGTGAACAGTCTGCAGTGGGCTATGGTTTCTTGTCAAGTCTTATTTCCTTA           TCATCCCATTAAATGTTGTCATTTTGCAAA                                                   NOV52a CG59584-03   SEQ ID NO:1092   1593 aa   MW at 180167.3 kD               Protein                     MIKLLNPDNSPIPNEVVQLHLKDKIVGNYTTDVNGIAQFFLDTYTFTYPNITLKAAYKANENCQAHGW           VLPQYPQPEYFAYRFYSKMNSFLKIVQEMEELRCNQQKRVLVHCILNMEDFEDKTYTADFNYLVISKG       VIILHGQQKIEINENGRKGIFSISIDINPELAPSVDMLVYSLHPGGEMVTDSTQFRIEKCFENQVNLN       FSKEKSLPGSNIDLQVSAASNSLCALWAVDQSVLLLRNYGQLSAQTVYSQLYSRELHGYYFRGLNLED       GLKVPCLEDEHILYNGIYYTPAWADFGKDGYDLVKDPQNNRIFQRQNVTSFRNITQLSFQLISEPMFG       DYWIVVKRNSRETVTHQFAVKRYVLPKFEVTVNAPQTVTISDDEFQVDVCAKYNFGQPVQGETQIRVC       REYFSSSNCEKNENEICEQFIAQLENGCVSQIVNTKVFQLYRSGLFMTFHVAVIVTESGTVMQISEKT       SVFITQLLGTVNFENMDTFYRRGISYFGTLKFSDPNNVPMVNKLLQLELNDEFIGNYTTDENGEAQFS       IDTSDIFDPEFNLKATYVRPESCYLPSWLTPQYLDAHFLVSRFYSRTNSFLKIVPEPKQLECNQQKVV       TVHYSLNSEAYEDDSNVKFFYLMMVKGAILLSGQKEIRNKAWNGNFSFPISISADLAPAAVLFVYTLH       PSGEIVADSVRFQVDKCFKHKVNIKFSNEQGLPGSNASLCLQAAPVLFCALRAVDRNVLLLKSEQQLS       AESVYNMVPSIEPYGYFYHGLNLDDGKEDPCIPQRDMFYNGLYYTPVSNYGDGDIYNIVPNMGLKVFT       NLHYRKPEKIMVQCVVFRLELHVASGIRGENADYVEQAIIQTVRTNFPETWMWDLVSVDSSGSANLSF       LIPDTITQWEASGFCVNGDVGFGISSTTTLEVSQPFFIEIASPFSVVQNEQFDLIVNVFSYRNTCVEI       SVQVEESQNYEANIHTLKINGSEVIQAGGRKTNVWTIIPKKLGKVNITVVAESKQSSACPNEGMEQQK       LNWKDTVVQSFLVEPEGIEKERTQSFLICTEGAKASKQGVLDLPNDVVEGSARGFFTVVGDILGLALQ       NLVVLQMPYGSGEQNAALLASDTYVLDYLKSTEQLTEEVQSKAFFLLSNGYQRQLSFKNSDGSYSVFW       QQSQKGSIWLSALTFKTLERMKKYVFIDENVQKQTLIWLSSQQKTSGCFKNDGQLFNHAWEGGDEEDI       SLTAYVVGMFFEAGLNFTFPALRNALFCLEAALDSGVTNGYNHAILAYAFALAGKEKQVESLLQTLDQ       SAPKLNNVIYWERERKPKTEEFPSFIPWAPSAQTEKSCYVLLAVISRKIPDLTYASKIVQWLAQRMNS       HGGFSSNQTPDDTLFKLYTGQKESFRSSSVGYTLGKANEKKENRRNGGEGSSEIFQVNGHNRLLVQRS       EVTQAPGEYTVDVEGHGCTFIQATLKYNVLLPKKASGFSLSLEIVKNYSSTAFDLTVTLKYTGIRNKS       SMVVIDVKMLSGFTPTMSSIEELENKGQVMKTEVKNDHVLFYLENVGFGRADSFPFSVEQSNLVFNIQ       PAPAMVYDYYEKEEYALAFYNIDSSSVSE                                     NOV52b, CG59584-02   SEQ ID NO:1093   4501 bp           DNA Sequence   ORF Start: at 1   ORF Stop: TGA at 4309                     TCCATTTCTATAGACATTAACCCTGAATTAGCGCCCTCAGTAGATATGCTTGTCTATAGCTTGCATCC           TGGAGGAGAAATGGTCACTGATAGCACCCAATTCCGAATTGAGAAATGCTTCGAAAATCAGGTCAACT       TAAATTTTTCTAAAGAAAAAAGTTTACCAGGATCCAATATTGATCTTCAAGTCTCGGCTGCTTCAAAC       TCTCTTTGTGCTCTTTGGGCTGTAGACCAGAGTGTATTGCTACTAAGGAATTATGGTCAGCTGTCAGC       ACAAACTGTGTATAGTCAGCTATATTCCAGGGAACTACATGGCTATTACTTCAGAGGACTTAACTTAG       AAGATGGCCTTAAAGTGCCGTGTCTTGAAGATGAACATATCCTTTACAATGGAATTTATTACACACCT       GCATGGGCTGACTTTGGAAAAGATGGCTATGACCTTGTGAAGGATCCTCAAAACAATCGGATTTTTCA       AAGGCAAAATGTGACTTCTTTCCGAAATATTACCCAACTCTCGTTCCAACTGATTTCAGAACCAATGT       TTGGAGATTACTGGATTGTTGTGAAAAGAAACTCAAGGGAGACAGTGACACACCAATTTGCTGTTAAA       AGATATGTGCTGCCCAAGTTTGAAGTTACAGTCAATGCACCACAAACAGTAACTATTTCAGATGATGA       ATTCCAAGTGGATGTATGTGCTAAGTACAACTTTGGCCAACCTGTGCAAGGGGAAACCCAAATCCGGG       TGTGCAGAGAGTATTTTTCTTCAAGCAATTGTGAGAAAAATGAAAATGAAATATGTGAGCAATTTATT       GCACAGTTGGAAAATGGTTGTGTTTCTCAAATTGTAAATACAAAAGTCTTCCAACTCTACCGTTCGGG       ATTGTTCATGACATTTCATGTCGCTGTAATTGTTACAGAATCTGGGACAGTTATGCAGATCAGCGAGA       AGACCTCAGTTTTTATCACTCAATTGCTTGGAACTGTAAACTTTGAGAACATGGATACATTCTATAGA       AGAGGGATTTCTTATTTTGGAACTCTTAAATTTTCGGATCCCAATAATGTACCTATGGTGAACAAGTT       GTTGCAACTGGAGCTCAATGATGAATTTATAGGAAATTACACTACGGATGAGAATGGCGAAGCTCAAT       TTTCCATTGACACTTCAGACATATTTGATCCAGAGTTCAACCTAAAAGCCACATATGTTCGACCTGAG       AGCTGCTATCTTCCCAGCTGGTTGACGCCTCAGTACTTGGATGCTCACTTCTTAGTCTCACGCTTTTA       CTCCCGAACCAACAGCTTCCTGAAGATTGTTCCAGAACCAAAGCAGCTTGAATGTAATCAACAGAAGG       TTGATGATGGTAAAAGGAGCTATCTTACTCAGTGGACAAAAGGAAATCAGAAACAAAGCCTGGAATGG       TTCACCCCAGTGGGGAAATTGTGGCTGACAGTGTCAGATTCCAGGTTGACAAGTGCTTTAAACACAAG       GTTAACATAAAGTTCTCTAACGAGCAGGGCTTACCTGGTTCCAATGCTAGTCTCTGTCTTCAAGCGGC       GCCTGTCTTATTCTGTGCCCTCAGGGCTGTGGATAGGAATGTCCTTCTACTGAAATCTGAACAACAGC       TGTCAGCTGAAAGTGTGTATAACATGGTTCCAAGTATAGAGCCGTATGGTTATTTCTACCATGGCCTC       AATCTTGATGATGGCAAGGAAGACCCTTGCATTCCTCAGAGGGATATGTTCTACAATGGTTTATATTA       CACACCTGTAAGCAACTATGGGGATGGAGATATCTATAATATTGTCAGGAACATGGGTCTAAAAGTCT       TTACCAATCTCCATTACCGAAAACCAGAAAAAATTATGGTCCAATGCGTAGTGTTCCGTCTAGAATTG       CATGTAGCTAGTGGAATCAGAGGGGAGAATGCTGACTATGTAGAACAGGCTATAATTCAAACAGTAAG       AACAAACTTCCCAGAGACATGGATGTGGGACCTCGTCAGTGTCGATTCCTCAGGCTCTGCCAATCTTT       CGTTCCTCATTCCTGATACGATAACCCAATGGGAGGCAAGTGGCTTTTGTGTGAATGGTGACGTTGGA       TTTGGCATTTCCTCTACAACCACTCTAGAAGTCTCCCAACCTTTCTTTATTGAGATTGCCTCACCCTT       TTCGGTTGTTCAAAATGAACAATTTGATTTGATTGTCAATGTCTTCAGCTACCGGAATACATGTGTAG       AGATTTCTGTTCAAGTGGAGGAGTCTCAGAATTATGAAGCAAATATTCATACCTTGAAAATCAATGGC       AGTGAGGTTATTCAAGCTGGAGGGAGGAAAACAAACGTCTGGACTATTATACCTAAGAAATTGGGTAA       AGTGAATATCACTGTAGTTGCTGAGTCCAAACAAAGCAGTGCTTGCCCAAATGAAGGAATGGAGCAGC       AAAAGCTAAACTGGAAAGACACTGTGGTCCAAAGCTTCTTAGTAGAGCCTGAAGGTATTGAAAAGGAA       AGGACCCAGAGTTTCCTTATCTGTACAGAAGGTGCCAAAGCCTCCAAGCAGGGAGTTTTGGACTTGCC       AAACGATGTAGTAGAAGGGTCAGCCAGAGGCTTTTTCACTGTTGTGGGGGATATTCTAGGACTTGCCT       TGCAGAATCTGGTTGTTCTCCAAATGCCCTATGGAAGTGGAGAGCAGAATGCTGCCCTACTAGCATCT       GATACTTATGTTCTGGACTATCTGAAATCTACTGAGCAACTGACAGAGGAAGTTCAATCTAAGGCTTT       CTTTCTCTTATCTAATGGTTATCAAAGGCAATTATCTTTCAAAAACTCTGATGGTTCCTATAGTGTGT       TTTGGCAGCAGAGTCAGAAAGGAAGCATATGGCTCAGTGCTCTTACTTTTAAGACATTGGAGAGAATG       AAAAAATATGTATTCATTGATGAAAATGTTCAAAAACAGACCTTAATCTGGCTTTCAAGCCAACAGAA       AACAAGCGGCTGCTTTAAGAATGATGGCCAGCTTTTCAACCACGCCTGGGAGGGTGGAGATGAAGAGG       ACATTTCACTCACTGCGTATGTTGTTGGGATGTTCTTTGAAGCTGGGCTCAATTTCACTTTTCCTGCT       CTACGAAACGCACTCTTTTGCCTTGAAGCGGCATTGGACAGTGGTGTCACTAATGGCTATAATCATGC               AATTCTAGCTTATGCTTTTGCCTTAGCTGGAAAAGAGAAGCAAGTGGAATCTTTACTCCAAACCCTGG       ATCAATCTGCCCCAAAACTAAATAATGTCATCTACTGGGAAAGAGAAAGGAAACCCAAGACAGAAGAA       TTTCCATCCTTTATTCCCTGGGCACCTTCTGCTCAGACTGAGAAGAGTTGCTACGTGCTGTTGGCTGT       CATTTCCCGGAAAATTCCTGACCTCACCTATGCTAGTAAGATTGTGCAGTGGCTTGCCCAACGGATGA       ATTCCCATGGAGGCTTTTCTTCCAACCAGACACCTGATGATACTCTGTTCAAATTATATACGGGCCAA       AAAGAAAGCTTTCGCTCTAGTTCTGTGGGCTATACACTGGGAAAAGCAAATGAAAAGAAGGAAAACAG       GAGAAATGGGGGTGAAGGATCCAGTGAGATTTTCCAGGTTAACGGTCATAACCGCCTACTGGTCCAAC       GTTCAGAAGTAACACAGGCACCTGGAGAATACACAGTAGATGTGGAAGGACACGGTTGTACATTTATC       CAGGCCACCCTTAAGTACAATGTTCTCCTACCTAAGAAGGCATCTGGATTTTCTCTTTCCTTGGAAAT       AGTAAAGAACTACTCTTCGACTGCTTTTGACCTCACAGTGACCCTCAAATACACTGGAATTCGCAATA       AATCCAGTATGGTGGTTATAGATGTAAAAATGCTATCAGGATTTACTCCAACCATGTCATCCATTGAA       GAGCTTGAAAACAAGGGCCAAGTGATGAAGACTGAAGTCAAGAATGACCATGTTCTTTTCTACTTGGA       AAATGTAGGTTTTGGTCGAGCAGACAGTTTCCCTTTTTCTGTTGAGCAGAGCAACCTTGTGTTCAACA       TTCAGCCAGCCCCAGCCATGGTCTACGATTATTATGAAAAAGAAGAATATGCCCTAGCTTTTTACAAC       ATCGACAGTAGTTCAGTTTCCGAG TGA   GACAAAGCAATTACTAGAAGAGTTGGAGAAGCATTTCTTGT           AACAAACTGATTCTTCTGTATCAAACCTGGAAAAAAATCATGAACCATCTGACATCGTGAACAGTCTG           CAGTGGGCTATGGTTTCTTGTCAAGTCTTATTTCCTTATCATCCCATTAAATGTTGTCATTTTGCAAA           AAAAAAAAAAAAA                                                   NOV52b, CG59584-02   SEQ ID NO:1094   1436 aa   MW at 161836.4 kD               Protein Sequence                     SISIDINPELAPSVDMLVYSLHPGGEMVTDSTQFRIEKCFENQVNLNFSKEKSLPGSNIDLQVSAASN           SLCALWAVDQSVLLLRNYGQLSAQTVYSQLYSRELHGYYFRGLNLEDGLKVPCLEDEHILYNGIYYTP       AWADFGKDGYDLVKDPQNNRIFQRQNVTSFRNITQLSFQLISEPMFGDYWIVVKRNSRETVTHQFAVK       RYVLPKFEVTVNAPQTVTISDDEFQVDVCAKYNFGQPVQGETQIRVCREYFSSSNCEKNENEICEQFI       AQLENGCVSQIVNTKVFQLYRSGLFMTFHVAVIVTESGTVMQISEKTSVFITQLLGTVNFENMDTFYR       RGISYFGTLKFSDPNNVPMVNKLLQLELNDEFIGNYTTDENGEAQFSIDTSDIFDPEFNLKATYVRPE       SCYLPSWLTPQYLDAHFLVSRFYSRTNSFLKIVPEPKQLECNQQKVVTVHYSLNSEAYEDDSNVKFFY       LMMVKGAILLSGQKEIRNKAWNGNFSFPISISADLAPAAVLFVYTLHPSGEIVADSVRFQVDKCFKHK       VNIKFSNEQGLPGSNASLCLQAAPVLFCALRAVDRNVLLLKSEQQLSAESVYNMVPSIEPYGYFYHGL       NLDDGKEDPCIPQRDMFYNGLYYTPVSNYGDGDIYNIVRNMGLKVFTNLHYRKPEKIMVQCVVFRLEL       HVASGIRGENADYVEQAIIQTVRTNFPETWMWDLVSVDSSGSANLSFLIPDTITQWEASGFCVNGDVG       FGISSTTTLEVSQPFFIEIASPFSVVQNEQFDLIVNVFSYRNTCVEISVQVEESQNYEANIHTLKING       SEVIQAGGRKTNVWTIIPKKLGKVNITVVAESKQSSACPNEGMEQQKLNWKDTVVQSFLVEPEGIEKE       RTQSFLICTEGAKASKQGVLDLPNDVVEGSARGFFTVVGDILGLALQNLVVLQMPYGSGEQNAALLAS       DTYVLDYLKSTEQLTEEVQSKAFFLLSNGYQRQLSFKNSDGSYSVFWQQSQKGSIWLSALTFKTLERM       KKYVFIDENVQKQTLIWLSSQQKTSGCFKNDGQLFNHAWEGGDEEDISLTAYVVGMFFEAGLNFTFPA       LRNALFCLEAALDSGVTNGYNHAILAYAFALAGKEKQVESLLQTLDQSAPKLNNVIYWERERKPKTEE       FPSFIPWAPSAQTEKSCYVLLAVISRKIPDLTYASKIVQWLAQRMMSHGGFSSNQTPDDTLFKLYTGQ       KESFRSSSVGYTLGKANEKKENRRNGGEGSSEIFQVNGHNRLLVQRSEVTQAPGEYTVDVEGHGCTFI       QATLKYNVLLPKKASGFSLSLEIVKNYSSTAFDLTVTLKYTGIRNKSSMVVIDVKNLSGFTPTMSSIE       ELENKGQVMKTEVKNDHVLFYLENVGFGRADSFPFSVEQSNLVFNIQPAPAMVYDYYEKEEYALAFYN       IDSSSVSE                                     NOV52c 248210405   SEQ ID NO:1095   571 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAGATGTGAAGGATCCAGTGAGATTTTCCACCTTAACGGTCATAATCGCCTACTGGTCCAACGTT           CAGAAGTAACACAGGCACCTGGAGAATACACAGTAGATGTGGAAGGACACGGTTGTACATTTATCCAG       GCCACCCTTAAGTACAATGTTCTCCTACCTAAGAAGGCATCTGGATTTTCTCTTTCCTTGGAAATAGT       AAAGAACTACTCTTCGACTGCTTTTGACCTCACAGTGACCCTCAAATACACTGGAATTCGCAATAAAT       CCAGTATGGTGGTTATAGATGTAAAAATGCTATCAGGATTTACTCCAACCATGTCATCCATTGAAGAG       CTTGAAAACAAGGGCCAAGTGATGAAGACTGAAGTCAAGAATGACCATGTTCTTTTCTACTTGGAAAA       TGGTTTTGGTCGAGCAGACAGTTTCCCTTTTTCTGTTGAGCAGAGCAACCTTGTGTTCAACATTCAGC       CAGCCCCAGCCATGGTCTACGATTACTATGAAAAAGAAGAATATGCCCTAGCTTTTTACAACATCGAC       AGTAGTTCAGTTTCCGAGCTCGAGGGC                                                 NOV52c, 248210405   SEQ ID NO:1096   190 aa   MW at 21231.7 kD               Protein Sequence                     TRSEGSSEIFQVNGHNRLLVQRSEVTQAPGEYTVDVEGHGCTFIQATLKYNVLLPKKASGFSLSLEIV           KNYSSTAFDLTVTLKYTGIRNKSSMVVIDVKMLSGFTPTMSSIEELENKGQVMKTEVKNDHVLFYLEN       GFGRASFPFSVEQSNLVFNIQPAPDYYEKEEYALAFYNIDSSSVSELEG                                     NOV52d, 248210436   SEQ ID NO:1097   571 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAGATCTGAAGGATCCAGTGAGATTTTCCAGGTTAACGGTCATAACCGCCTACTGGTCCAACGTT           CAGAAGTAACACAGGCACCTGGACAATACACAGTAGATGTGGAAGGACACGGTTGTACATTTATCCAG       GCCACCCTTAAGTACAATGTTCTCCTACCTAAGAAGGCATCTGGATTTTCTCTTTCCTTGGAAATAGT       AAAGAACTACTCTTCGACTGCTTTTGACCTCACAGTGACCCTCAAATACACTGGAATTCGCAATAAAT       CCAGTATGGTGGTTATAGATGTAAAAATGCTATCAGGATTTACTCCAACCATGTCATCCATTGAAGAG       CTTGAAAACAAGGGCCAAGTGATGAAGACTGAAGTCAAGAATGACCATGTTCTTTTCTACTTGGAAAA       TGGTTTTGGTCGAGCAGACAGTTTCCCTTTTTCTGTTGAGCAGAGCAACCTTGTGTTCAACATTCAGC       CAGCCCCAGCCATGGTCTACGATTACTATGAAAAAGAAGAATATGCCCTAGCTTTTTACAACATCGAC       AGTAGTTCAGTTTCCGAGCTCGAGGGC                                                 NOV52d, 248210436   SEQ ID NO:1098   190 aa   MW at 21230.7 kD               Protein Sequence                     TRSEGSSEIFQVNGHNRLLVQRSEVTQAPGQYTVDVEGHGCTFIQATLKYNVLLPKKASGFSLSLEIV           KNYSSTAFDLTVTLKYTGIRNKSSMVVIDVKMLSGFTPTMSSIEELENKGQVMKTEVKNDHVLFYLEN       GFGRADSFPFSVEQSNLVFNIQPAPAMVYDYYEKEEYALAFYNIDSSSVSELEG                                     NOV52e 249357737   SEQ ID NO:1099   571 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAGATCTGAAGGATCCAGTGAGATTTTCCAGGTTAACGGTCATAACCGCCTACTGGTCCAACGTT           CAGAAGTAACACAGGCACCTGGACAATACACAGTAGATGTGGAAGGACACGGTTGTACATTTATCCAG       GCCACCCTTAAGTACGATGTTCTCCTACCTAAGAAGGCATCTGGATTTTCTCTTTCCTTGGAAATAGT       AAAGAACTACTCTTCGACTGCTTTTGACCTCACAGTGACCCTCAAATACACTGGAATTCGCAATAAAT       CCAGTATGGTGGTTATAGATGTAAAAATGCTATCAGGATTTACTCCAACCATGTCATCCATTGAAGAG       CTTGAAAACAAGGGCCAAGTGATGAAGACTGAAGTCAAGAATGACCATGTTCTTTTCTACTTGGAAAA       TGGTTTTGGTCGAGCAGACAGTTTCCCTTTTTCTGTTGAGCAGAGCAACCTTGTGTTCAACATTCAGC       CAGCCCCAGCCATGGTCTACGATTACTATGAAAAAGAAGAATATGCCCTAGCTTTTTACAACATCGAC       AGTAGTTCAGTTTCCGAGCTCGAGGGC                                                 NOV52e, 249357737   SEQ ID NO:1100   190 aa   MW at 21231.7 kD               Protein Sequence                     TRSEGSSEIFQVNGHNRLLVQRSEVTQAPGQYTVDVEGHGCTFIQATLKYDVLLPKKASGFSLSLEIV           KNYSSTAFDLTVTLKYTGIRNKSSMVVIDVKMLSGFTPTMSSIEELENKGQVMKTEVKNDHVLFYLEN       GFGRADSFPFSVEQSNLVFNIQPAPDYYEKEEYALAFYNIDSSSVSELEG                                     NOV52f, 248210430   SEQ ID NO:1101   529 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAGATCTGAAGGATCCAGTGAGATTTTCCAGGTTAACGGTCATAACCGCCTACTGGTCCAACGTT           CAGAAGTAACACAGGCACCTGGACAATACACAGTAGATGTGGAAGGACACGGTTGTACATTTATCCAG       GCCACCCTTAAGTACAATGTTCTCCTACCTAAGAAGGCATCTGGATTTTCTCTTTCCTTGGAAATAGT       AAAGAACTACTCTTCGACTGCTTTTGACCTCACAGTGACCCTCAAATACACTGGAATTCGCAATAAAT       CCAGTATGGTGGTTATAGATGTAAAAATGCTATCAGGATTTACTCCAACCATGTCATCCATTGAAGAG       CTTGAAAACAAGGGCCAAGTGATGAAGACTGAAGTCAAGAATGACCATGTTCTTTTCTACTTGGAAAA       TAGCAACCTTGTGTTCAACATTCAGCCAGCCCCAGCCATGGTCTACGATTACTATGAAAAAGAAGAAT       ATGCCCTAGCTTTTTACAACATCGACAGTAGTTCAGTTTCCGAGCTCGAGGGC                                                 NOV52f, 248210430   SEQ ID NO:1102   176 aa   MW at 19705.1 kD               Protein Sequence                     TRSEGSSEIFQVNGHNRLLVQRSEVTQAPGQYTVDVEGHGCTFIQATLKYNVLLPKKASGFSLSLEIV           KNYSSTAFDLTVTLKYTGIRNKSSMVVIDVKMLSGFTPTMSSIEELENKGQVMKTEVKNDHVLFYLEN       SNLVFNIQPAPAMVYDYYEKEEYALAFYNIDSSSVSELEG                                     NOV52g, 249357755   SEQ ID NO:1103   547 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCAGATCTGAAGGATCCAGTGAGATTTTCCAGGTTAACGGTCATAATCGCCTACTGGTCCAACGTT           CAGAAGTAACACAGGCACCTGGACAATACACAGTAGATGTGGAAGGACACGGTTGTACATTTATCCAG       GCCACCCTTAAGTACAATGTTCTCCTACCTAAGAAGGCATCTGGATTTTCTCTTTCCTTGGAAATAGT       AAAGAACTACTCTTCGACTGCTTTTGACCTCACAGTGACCCTCAAATACACTGGAATTCGCAATAAAT       CCAGTATGGTGGTTATAGATGTAAAAATGCTATCAGGATTTACTCCAACCATGTCATCCACTGAAGAG       CTTGAAAACAAGGGCCAAGTGATGAAGACTGAAGTCAAGAATGACCATGTTCTTTTCTACTTGGAAAA       TAGCAACCTTGTGTTCAACATTCAGCCAGCCCCAGCCATGGTCTACGATTACTATGAAAAAGAAGAAT       ATGCCCTAGCTTTTTACAACATCGACAGTAGTTCAGTTTCCGAGCTCGAGGGCAAGGGCGAATCCAGC       ACA                                                 NOV52g, 249357755   SEQ ID NO:1104   182 aa   MW at 20282.6 kD               Protein Sequence                     TRSEGSSEIFQVNGHNRLLVQRSEVTQAPGQYTVDVEGHGCTFIQATLKYNVLLPKKASGFSLSLEIV           KNYSSTAFDLTVTLKYTGIPNKSSMVVIDVKMLSGFTPTMSSTEELENKGQVMKTEVKNDHVLFYLEN       SNLVFNIQPAPAMVYDYYEKEEYALAFYNIDSSSVSELEGKGESST                                     NOV52h, CG59584-01   SEQ ID NO:1105   4426 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TGA at 4234                       ATG TACTGTTTTTTGCGATCTGCCGTTTCGTTCTTCTGCCTCAGCCTCCCCAGGTGCTGGGGTTATAG           GTGTGAGCCACTGTGCCTGGCTATTCTTTTATTACAGTATGTTCTGCTGATTCCTTCTGTTCTACAAG       AAGGCTCTTTGGATAAAGCTTGTGCCCAGCTTTTTAATCTCACTGAATCTGTTGTTTTGACGGTCTCC       CTCAACTATGGTGAGGTCCAGACCAAAATATTTGAAGAAAATGTTACTGGAGAAAATTTCTTCAAATG       CATCAGCTTTGAGGTTCCTCAGGCCAGATCTGACCCACTGGCATTTATTACATTTTCTGCTAAAGGAG       CCACTCTCAACCTGGAAGAGAGGAGATCTGTGGCAATCAGATCCAGAGAGAATGTGGTCTTTGTACAG       ACTGATAAACCCACCTACAAGCCTGGACAGTATAATAAAAAGCCGATCAGTCACATAATGCCAGTGAT       AGCAGTCACTGAACAGGATCCAGAAGGCAATCGAATACAACAGTGGGTGAATGAGGAGTCTGTGGGAG       GGATTCTACAACTCTCCTTCCAGTTAATCTCAGAGCCCATCCTCGGATGGTATGAAATCACCGTGGAG       ATGCTCAATGAGAAGAAAACATATCACTCCTTCTCTGTGGAAGAATATGTGTTACCCAAATTTCAAAT       GACTGTGGATGCACCAGAAAATATCTTAGTTGTGGACTCTGAATTCAAAGTGAATGTCTGTGCCTTGT       ATACCTATGGTGAACCTGTGGACGGGAAGGTCCAACTTAGTGTGTGCAGAGAATCTACGGCTTATCAT       TCATGTGCTCATCTTATCAGTTCACTCTGTAAAAATTTTACCTTGGGGAAAGATGGCTGTGTCTCCAA       GTTTATTAACACAGATGCTTTTGAGTTAAATCGGGAAGGATACTGGAGTTTCCTCAAAGTGCATGCTC       TTGTTACAGAGCTTACAGGCTCCAAGTACGTATACATAGACTCATCAGTGGTGAAGATTAGTTTTGAG       ATGTAAATGGCATCGCTCAGTTTTTCTTGGACACATATACGTTTACATACCCAAATATCACTTTGAAA       GCAGCCTACAAGGCCAATGAAAATTGCCAGGCTCATGGCTGGGTGTTGCCTCAATACCCTCAGCCCGA       GTACTTTGCATATCGATTTTACTCCAAGATGAATAGCTTCCTAAAGATTGTCCAAGAGATGGAAGAAC       TGAGATGCAACCAGCAGAAGAGGGTGCTAGTGCACTGCATTCTCAATATGGAAGACTTTGAAGACAAA       ACCTACACAGCAGACTTCAATTATTTGGTGATTTCAAAAGGTGTAATCATTCTTCATGGGCAACAGAA       AATTGAGATCAACGAAAATGGGAGGAAGGGCATATTTTCCATTTCTATAGACATTAACCCTGAATTAG       CGCCCTCAGTACATATGCTTGTCTATAGCTTGCATCCTGGAGGAGAAATGGTCACTGATAGCACCCAA       TTCCAATTGAGAAATGTTAACATAAAGTTCTCTAACGAGCAGGGCTTACCTGGTTCCAATGCTAGTCT       CTGTCTTCAAGCGGCGCCTGTCTTATTCTGTGCCCTCAGGGCTGTGGATAGGAATGTCCTTCTACTGA       AATCTGAACAACAGCTGTCAGCTGAAAGTGTGTATAACATGGTTCCAAGTATAGAGCCGTATGGTTAT       TTCTACCATGGCCTCAATCTTGATGATGGCAAGGAAGACCCTTGCATTCCTCAGAGGGATATGTTCTA       CAATGGTTTATATTACACACCTGTAAGCAACTATGGGGATGGAGATATCTATAATATTGTCAGGAACA       TGGGTCTAAAAGTCTTTACCAATCTCCATTACCGAAAACCAGAAGTATGTGTGATGGAGAGAAGGCTG       CCACTCCCTAAGCCGCTTTATCTGGAAACAGAAAATTATGGTCCAATGCGTAGTGTTCCGTCTAGAAT       TGCATCTAGTGGAATCAGAGGGGAGAATGCTGACTATGTAGAACAGGCTATAATTCAAACAGTAAGAA       CAAACTTCCCAGAGACATGGATGTGGGACCTCGTCAGTGTCGATTCCTCAGGCTCTGCCAATCTTTCG       TTCCTCATTCCTGATACGATAACCCAATGGGAGGCAAGTGGCTTTTGTGTGAATGGTGACGTTGGATT       TGGCATTTCCTCTACAACCACTCTAGAAGTCTCCCAACCTTTCTTTATTGAGATTGCCTCACCCTTTT       CGGTTGTTCAAAATGAACAATTTGATTTGATTGTCAATGTCTTCAGCTACCGGAATACATGTGTAGAG       ATTTCTGTTCAAGTGGAGGAGTCTCAGAATTATGAAGCAAATATTCATACCTTGAAAATCAATGGCAG       TGAGGTTATTCAAGCTGGAGGGAGGAAAACAAACGTCTGGACTATTATACCTAAGAAATTGGGCAAAG       TGAATATCACTGTAGTTGCTGAGTCCAAACAAAGCAGTGCTTGCCCAAATGAAGGAATGGAGCAGCAA       AAGCTAAACTGGAAAGACACTGTGGTCCAAAGCTTCTTAGTAGAGCCTGAAGGTATTGAAAAGGAAAG       GACCCAGAGTTTCCTTATCTGTACAGAAGGTGCCAAAGCCTCCAAGCAGGGAGTTTTGGACTTGCCAA       ACGATGTAGTAGAAGGGTCAGCCAGAGGCTTTTTCACTGTTGTGGGGGATATTCTAGGACTTGCCTTG       CAGAATCTGGTTGTTCTCCAAATGCCCTATGGAAGTGGAGAGCAGAATGCTGCCCTACTAGCATCTGA       TACTTATGTTCTGGACTATCTGAAATCTACTGAGCAACTGACAGAGGAAGTTCAATCTAAGGCTTTCT       TTCTCTTATCTAATGGTTATCAAAGGCAATTATCTTTCAAAAACTCTGATGGTTCCTATAGTGTGTTT       TGGCAGCAGAGTCAGAAAGGAAGCATATGGCTCAGTGCTCTTACTTTTAAGACATTGGAGAGAATGAA       AAAATATGTATTCATTGATGAAAATGTTCAAAAACAGACCTTAATCTGGCTTTCAAGCCAACAGAAAA       CAAGCGGCTGCTTTAAGAATGATGGCCAGCTTTTCAACCACGCCTGGCAGGGTGGAGATGAAGAGGAC       ATTTCACTCACTGCGTATGTTGTTGGGATGTTCTTTGAAGCTGGGGCGGCATTGGACAGTGGTGTCAC               TAATGGCTATAATCATGCAATTCTAGCTTATGCTTTTGCCTTAGCTGGAAAAGAGAAGCAAGTGGAAT       CTTTACTCCAAACCCTGGATCAATCTGCCCCAAAACTAAATAATGTCATCTACTGGGAAAGAGAAAGG       AAACCCAAGACAGAAGAATTTCCATCCTTTATTCCCTGGGCACCTTCTGCTCAGACTGAGAAGAGTTG       CTACGTGCTGTTGGCTGTCATTTCCCGGAAAATTCCTGACCTCACCTATGCTAGTAAGATTGTGCAGT       GGCTTGCCCAACGGATGAATTCCCATGGAGGCTTTTCTTCCAACCAGGATCAAAACACTGTCACCTTT       AGCAGTGAAGGATCCAGTGAGATTTTCCAGGTTAACGGTCATAACCGCCTACTGGTCCAACGTTCAGA       AGTAACACAGGCACCTGGAGAATACACAGTAGATGTGGAAGGACACGGTTGTACATTTATCCAGGCCA       CCCTTAAGTACAATGTTCTCCTACCTAAGAAGGCATCTGGATTTTCTCTTTCCTTGGAAATAGTAAAG       AACTACTCTTCGACTGCTTTTGACCTCACAGTGACCCTCAAATACACTGGAATTCGCAATAAATCCAG       TATGGTGGTTATAGATGTAAAAATGCTATCAGGATTTACTCCAACCATGTCATCCATTGAAGAGCTTG       AAAACAAGGGCCAAGTGATGAAGACTGAAGTCAAGAATGACCATGTTCTTTTCTACTTGGAAAATGTA       GGTTTTGGTCGAGCAGACAGTTTCCCTTTTTCTGTTGAGCAGAGCAACCTTGTGTTCAACATTCAGCC       AGCCCCAGCCATGGTCTACGATTATTATGAAAAAGAAGAATATGCCCTAGCTTTTTACAACATCGACA       GTAGTTCAGTTTCCGAG TGA   GACAAAGCAATTACTAGAAGAGTTGGAGAAGCATTTCTTGTAACAAAC           TGATTCTTCTGTATCAAACCTGGAAAAAAATCATGAACCATCTGACATCGTGAACAGTCTGCAGTGGG           CTATGGTTTCTTGTCAAGTCTTATTTCCTTATCATCCCATTAAATGTTGTCATTTTGCAAAAAAAAAA           AAAAAA                                                   NOV52h, CG59584-01   SEQ ID NO:1106   1411 aa   MW at 158867.0 kD               Protein Sequence                     MYCFLRSAVSFFCLSLPRCWGYRCEPLCLAILLLQYVLLIPSVLQEGSLDKACAQLFNLTESVVLTVS           LNYGEVQTKIFEENVTGENFFKCISFEVPQARSDPLAFITFSAKGATLNLEERRSVAIRSRENVVFVQ       TDKPTYKPGQYNKKPISHIMPVIAVTEQDPEGNRIQQWVNEESVGGILQLSFQLISEPTLGWYEITVE       MLNEKKTYHSFSVEEYVLPKFQMTVDAPENILVVDSEFKVNVCALYTYGEPVDGKVQLSVCRESTAYH       SCAHLISSLCKNFTLGKDGCVSKFINTDAFELNREGYWSFLKVHALVTELTGSKYVYIDSSVVKISFE       NMDMSYKQGLPYFGQIKLLNPDNSPIPNEVVQLHLKDKIVGNYTTDVNGIAQFFLDTYTFTYPNITLK       AAYKANENCQAHGWVLPQYPQPEYFAYRFYSKMNSFLKIVQENEELRCNQQKRVLVHCILNMEDFEDK       TYTADFNYLVISKGVIILHGQQKIEINENGRKGIFSISIDINPELAPSVHMLVYSLHPGGEMVTDSTQ       FQLRNVNIKFSNEQGLPGSNASLCLQAAPVLFCALRAVDRNVLLLKSEQQLSAESVYNMVPSIEPYGY       FYHGLNLDDGKEDPCIPQRDMFYNGLYYTPVSNYGDGDIYNIVRNMGLKVFTNLHYRKPEVCVMERRL       PLPKPLYLETENYGPMRSVPSRIASSGIRGENADYVEQAIIQTVRTNFPETWMWDLVSVDSSGSANLS       FLIPDTITQWEASGFCVNGDVGFGISSTTTLEVSQPFFIEIASPFSVVQNEQFDLIVNVFSYRNTCVE       ISVQVEESQNYEANIHTLKINGSEVIQAGGRKTNVWTIIPKKLGKVNITVVAESKQSSACPNEGMEQQ       KLNWKDTVVQSFLVEPEGIEKERTQSFLICTEGAKASKQGVLDLPNDVXTEGSARGFFTWGDILGLAL       QNLVVLQMPYGSGEQNAALLASDTYVLDYLKSTEQLTEEVQSKAFFLLSNGYQRQLSFKNSDGSYSVF       WQQSQKGSIWLSALTFKTLERMKKYVFIDENVQKQTLIWLSSQQKTSGCFKNDGQLFNHAWQGGDEED       ISLTAYVVGMFFEAGAALDSGVTNGYNHAILAYAFALAGKEKQVESLLQTLDQSAPKLNNVIYWERER       KPKTEEFPSFIPWAPSAQTEKSCYVLLAVISRKIPDLTYASKIVQWLAQRMNSHGGFSSNQDQNTVTF       SSEGSSEIFQVNGHNRLLVQRSEVTQAPGEYTVDVEGHGCTFIQATLKYNVLLPKKASGFSLSLEIVK       NYSSTAFDLTVTLKYTGIRNKSSMVVIDVKMLSGFTPTMSSIEELENKGQVMKTEVKNDHVLFYLENV       GFGRADSFPFSVEQSNLVFNIQPAPAMVYDYYEKEEYALAFYNIDSSSVSE                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 52B.  
               TABLE 52B                       Comparison of the NOV52 protein sequences.                                                NOV52a   MIKLLNPDNSPIPNEVVQLHLKDKIVGNYTTDVNGIAQFFLDTYTFTYPNITLKAAYKAN   (SEQ ID NO:1092)                   NOV52b   ------------------------------------------------------------   (SEQ ID NO:1094)               NOV52c   ------------------------------------------------------------   (SEQ ID NO:1096)               NOV52d   ------------------------------------------------------------   (SEQ ID NO:1098)               NOV52e   ------------------------------------------------------------   (SEQ ID NO:1100)               NOV52f   ------------------------------------------------------------   (SEQ ID NO:1102)               NOV52g   ------------------------------------------------------------   (SEQ ID NO:1104)               NOV52h   ------------------------------------------------------------   (SEQ ID NO:1106)               NOV52a   ENCQAHGWVLPQYPQPEYFAYRFYSKMNSFLKIVQEMEELRCNQQKRVLVHCILNMEDFE               NOV52b   ------------------------------------------------------------               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   --------------------------MYCFLRSAVSFFCLSLPR----------------               NOV52a   DKTYTADFNYLVISKGVIILHGQQKIEINENGRKGIFSISIDINPELAPSVDMLVYSLHP               NOV52b   -------------------------------------SISIDINPELAPSVDMLVYSLHP               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   --------------------------------CWGYRCEPLCLAILLLQYVLLIPSVLQE               NOV52a   GGEMVTDSTQFRIEKCFENQVNLNFSKEKSLPGSNIDLQVSAASNSLCALWAVDQSVLLL               NOV52b   GGEMVTDSTQFRIEKCFENQVNLNFSKEKSLPGSNIDLQVSAASNSLCALWAVDQSVLLL               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   GSLDKACAQLFNLTESVVLTVSLNYGEVQTK---IFEENVTGENFFKCISFEVPQARSDP               NOV52a   RNYGQLSAQTVYSQLYSRELHGYYFRGLNLEDGLKVPCLEDEHILYNGIYYTPAWADFGK               NOV52b   RNYGQLSAQTVYSQLYSRELHGYYFRGLNLEDGLKVPCLEDEHILYNGIYYTPAWADFGK               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   LAFITFSAKGATLNLEERRSVAIRSRENVVFVQTDKPTYKPGQYNKKPISHIMPVIAVT-               NOV52a   DGYDLVKDPQNNRIFQRQNVTSFRNITQLSFQLISEPMFGDYWIVVKRNSRETVTHQFAV               NOV52b   DGYDLVKDPQNNRIFQRQNVTSFRNITQLSFQLTSEPMFGDYWIVVKRNSRETVTHQFAV               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   -----EQDPEGNRIQQWVNEESVGGILQLSFQLISEPILGWYEITVEMLNEKKTYHSFSV               NOV52a   KRYVLPKFEVTVNAPQTVTISDDEFQVDVCAKYNFGQPVQGETQIRVCREYFSSSNCEKN               NOV52b   KRYVLPKFEVTVNAPQTVTISDDEFQVDVCAKYNFGQPVQGETQIRVCREYFSSSNCEKN               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   EEYVLPKFQMTVDAPENILVVDSEFKVNVCALYTYGEPVDGKVQLSVCRESTAYHSCAHL               NOV52a   ENEICEQFIAQLENGCVSQIVNTKVFQLYRSGLFMTFHVAVIVTESGTVMQISEKTSVFI               NOV52b   ENEICEQFIAQLENGCVSQIVNTKVFQLYRSGLFMTFHVAVIVTESGTVMQISEKTSVFI               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   ISSLCKNFTLGKD-GCVSKFINTDAFELNREGYWSFLKVEALVTE------LTGSKYVYI               NOV52a   TQLLGTVNFENMDTFYRRGISYFGTLKFSDPNNVPMVNKLLQLELNDEFIGNYTTDENGE               NOV52b   TQLLGTVNFENMDTFYRRGISYFGTLKFSDPNNVPMVNKLLQLELNDEFIGNYTTDENGE               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   DSSVVKISFENMDMSYKQGLPYFGQIKLLNPDNSPIPNEVVQLHLKDKIVGNYTTDVNGI               NOV52a   AQFSIDTSDIFDPEFNLKATYVRPESCYLPSWLTPQYLDAHFLVSRFYSRTNSFLKIVPE               NOV52b   AQFSIDTSDIFDPEFNLKATYVRPESCYLPSWLTPQYLDAHFLVSRFYSRTNSFLKIVPE               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   AQFFLDTYTFTYPNITLKAAYKANENCQAHGWVLPQYPQPEYFAYRFYSKMNSFLKIVQE               NOV52a   PKQLECNQQKVVTVHYSLNSEAYEDDS-NVKFFYLMMVKGAILLSGQK--EIRNKAWNGN               NOV52b   PKQLECNQQKVVTVHYSLNSEAYEDDS-NVKFFYLMMVKGAILLSGQK--EIRNKAWNGN               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   MEELRCNQQKRVLVHCILNMEDFEDKTYTADFNYLVISKGVIILHGQQKIEINENGRKGI               NOV52a   FSFPISISADLAPAAVLFVYTLHPSGEIVADSVRFQVDKCFKHKVNIKFSNEQGLPGSNA               NOV52b   FSFPISISADLAPAAVLFVYTLHPSGEIVADSVRFQVDKCFKHKVNIKFSNEQGLPGSNA               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   FSISIDINPELAPSVHMLVYSLHPGGEMVTDSTQFQLR-----NVNIKFSNEQGLPGSNA               NOV52a   SLCLQAAPVLFCALRAVDRNVLLLKSEQQLSAESVYNMVPSIEPYGYFYHGLNLDDGKED               NOV52b   SLCLQAAPVLFCALRAVDRNVLLLKSEQQLSAESVYNMVPSIEPYGYFYHGLNLDDGKED               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   SLCLQAAPVLFCALRAVDRNVLLLKSEQQLSAESVYNMVPSIEPYGYFYHGLNLDDGKED               NOV52a   PCIPQRDMFYNGLYYTPVSNYGDGDIYNIVPNMGLKVFTNLHYRKPEKIMVQCVVFR---               NOV52b   PCIPQRDMFYNGLYYTPVSNYGDGDIYNIVRNMGLKVFTNLHYRKPEKIMVQCVVFR---               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   PCIPQRDMFYNGLYYTPVSNYGDGDIYNIVRNMGLKVFTNLHYRKPEVCVMERRLPLPKP               NOV52a   --------------LELHVASGIRGENADYVEQAIIQTVRTNFPETWMWDLVSVDSSGSA               NOV52b   --------------LELRVASGIRGENADYVEQAIIQTVRTNFPETWMWDLVSVDSSGSA               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   LYLETENYGPMRSVPSRIASSGIRGENADYVEQAIIQTVRTNFPETWMWDLVSVDSSGSA               NOV52a   NLSFLIPDTITQWEASGFCVNGDVGFGISSTTTLEVSQPFFIEIASPFSVVQNEQFDLIV               NOV52b   NLSFLIPDTITQWEASGFCVNGDVGFGISSTTTLEVSQPFFIEIASPFSVVQNEQFDLIV               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   NLSFLIPDTITQWEASGFCVNGDVGFGISSTTTLEVSQPFFIEIASPFSVVQNEQFDLIV               NOV52a   NVFSYRNTCVEISVQVEESQNYEANIHTLKINGSEVIQAGGRKTNVWTIIPKKLGKVNIT               NOV52b   NVFSYRNTCVEISVQVEESQNYEANIHTLKINGSEVIQAGGRKTNVWTIIPKKLGKVNIT               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   NVFSYRNTCVEISVQVEESQNYEANIHTLKINGSEVIQAGGRKTNVWTIIPKKLGKVNIT               NOV52a   VVAESKQSSACPNEGMEQQKLNWKDTVVQSFLVEPEGIEKERTQSFLICTEGAKASKQGV               NOV52b   VVAESKQSSACPNEGMEQQKLNWKDTVVQSFLVEPEGIEKERTQSFLICTEGAKASKQGV               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   VVAESKQSSACPNEGMEQQKLNWKDTVVQSFLVEPEGIEKERTQSFLICTEGAKASKQGV               NOV52a   LDLPNDVVEGSARGFFTVVGDILGLALQNLVVLQMPYGSGEQNAALLASDTYVLDYLKST               NOV52b   LDLPNDVVEGSARGFFTVVGDILGLALQNLVVLQMPYGSGEQNAALLASDTYVLDYLKST               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   LDLPNDVVEGSARGFFTVVGDILGLALQNLVVLQMPYGSGEQNAALLASDTYVLDYLKST               NOV52a   EQLTEEVQSKAFFLLSNGYQRQLSFKNSDGSYSVFWQQSQKGSIWLSALTFKTLERMKKY               NOV52b   EQLTEEVQSKAFFLLSNGYQRQLSFKNSDGSYSVFWQQSQKGSIWLSALTFKTLERMKKY               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   EQLTEEVQSKAFFLLSNGYQRQLSFKNSDGSYSVFWQQSQKGSIWLSALTFKTLERMKKY               NOV52a   VFIDENVQKQTLIWLSSQQKTSGCFKNDGQLFNHAWEGGDEEDISLTAYVVGMFFEAGLN               NOV52b   VFIDENVQKQTLIWLSSQQKTSGCFKNDGQLFNHAWEGGDEEDISLTAYVVGMFFEAGLN               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   VFIDENVQKQTLIWLSSQQKTSGCFKNDGQLFNHAWQGGDEEDISLTAYVVGMFFEAGA-               NOV52a   FTFPALRNALFCLEAALDSGVTNGYNHAILAYAFALAGKEKQVESLLQTLDQSAPKLNNV               NOV52b   FTFPALRNALFCLEAALDSGVTNGYNHAILAYAFALAGKEKQVESLLQTLDQSAPKLNNV               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   ---------------ALDSGVTNGYNHAILAYAFALAGKEKQVESLLQTLDQSAPKLNNV               NOV52a   IYWERERKPKTEEFPSFIPWAPSAQTEKSCYVLLAVISRKIPDLTYASKIVQWLAQRMNS               NOV52b   IYWERERKPKTEEFPSFIPWAPSAQTEKSCYVLLAVISRKIPDLTYASKIVQWLAQRMNS               NOV52c   ------------------------------------------------------------               NOV52d   ------------------------------------------------------------               NOV52e   ------------------------------------------------------------               NOV52f   ------------------------------------------------------------               NOV52g   ------------------------------------------------------------               NOV52h   IYWERERKPKTEEFPSFIPWAPSAQTEKSCYVLLAVISRKIPDLTYASKIVQWLAQRMNS               NOV52a   HGGFSSNQTPDDTLFKLYTGQKESFRSSSVGYTLGKANEKKENRRNGGEGSSEIFQVNGH               NOV52b   HGGFSSNQTPDDTLFKLYTGQKESFRSSSVGYTLGKANEKKENRRNGGEGSSEIFQVNGH               NOV52c   ------------------------TRS---------------------EGSSEIFQVNGH               NOV52d   ------------------------TRS---------------------EGSSEIFQVNGH               NOV52e   ------------------------TRS---------------------EGSSEIFQVNGH               NOV52f   ------------------------TRS---------------------EGSSEIFQVNGH               NOV52g   ------------------------TRS---------------------EGSSEIFQVNGH               NOV52h   HGGFSSNQDQNT----------VTFSS---------------------EGSSEIFQVNGH               NOV52a   NRLLVQRSEVTQAPGEYTVDVEGHGCTFIQATLKYNVLLPKKASGFSLSLEIVKNYSSTA               NOV52b   NRLLVQRSEVTQAPGEYTVDVEGHGCTFIQATLKYNVLLPKKASGFSLSLEIVKNYSSTA               NOV52c   NRLLVQRSEVTQAPGEYTVDVEGHGCTFIQATLKYNVLLPKKASGFSLSLEIVKNYSSTA               NOV52d   NRLLVQRSEVTQAPGQYTVDVEGHGCTFIQATLKYNVLLPKKASGFSLSLEIVKNYSSTA               NOV52e   NRLLVQRSEVTQAPGQYTVDVEGHGCTFIQATLKYDVLLPKKASGFSLSLEIVKNYSSTA               NOV52f   NRLLVQRSEVTQAPGQYTVDVEGHGCTFIQATLKYNVLLPKKASGFSLSLEIVKNYSSTA               NOV52g   NRLLVQRSEVTQAPGQYTVDVEGHGCTFIQATLKYNVLLPKKASGFSLSLEIVKNYSSTA               NOV52h   NRLLVQRSEVTQAPGEYTVDVEGHGCTFIQATLKYNVLLPKKASGFSLSLEIVKNYSSTA               NOV52a   FDLTVTLKYTGIRNKSSMVVIDVKMLSGFTPTMSSIEELENKGQVMKTEVKNDHVLFYLE               NOV52b   FDLTVTLKYTGIRNKSSMVVIDVKMLSGFTPTMSSIEELENKGQVMKTEVKNDHVLFYLE               NOV52C   FDLTVTLKYTGIRNKSSMVVIDVKMLSGFTPTMSSIEELENKGQVMKTEVKNDHVLFYLE               NOV52d   FDLTVTLKYTGIRNKSSMVVIDVKMLSGFTPTMSSIEELENKGQVMKTEVKNDHVLFYLE               NOV52e   FDLTVTLKYTGIRNKSSMVVIDVKMLSGFTPTMSSIEELENKGQVMKTEVKNDHVLFYLE               NOV52f   FDLTVTLKYTGIRNKSSMVVIDVKMLSGFTPTMSSIEELENKGQVMKTEVKNDHVLFYLE               NOV52g   FDLTVTLKYTGIRNKSSMVVIDVKMLSGFTPTMSSTEELENKGQVMKTEVKNDHVLFYLE               NOV52h   FDLTVTLKYTGIRNKSSMVVIDVKMLSGFTPTMSSIEELENKGQVMKTEVKNDHVLFYLE               NOV52a   NVGFGRADSFPFSVEQSNLVFNIQPAPAMVYDYYEKEEYALAFYNIDSSSVSE-------               NOV52b   NVGFGRADSFPFSVEQSNLVFNIQPAPAMVYDYYEKEEYALAFYNIDSSSVSE-------               NOV52c   NG-FGRADSFPFSVEQSNLVFNIQPAPAMVYDYYEKEEYALAFYNIDSSSVSELEG----               NOV52d   NG-FGRADSFPFSVEQSNLVFNIQPAPAMVYDYYEKEEYALAFYNIDSSSVSELEG----               NOV52e   NG-FGRADSFPFSVEQSNLVFNIQPAPAMVYDYYEKEEYALAFYNIDSSSVSELEG----               NOV52f   NS---------------NLVFNIQPAPAMVYDYYEKEEYALAFYNIDSSSVSELEG----               NOV52g   NS---------------NLVFNIQPAPAMVYDYYEKEEYALAFYNIDSSSVSELEGKGES               NOV52h   NVGFGRADSFPFSVEQSNLVFNIQPAPAMVYDYYEKEEYALAFYNIDSSSVSE-------               NOV52a   --               NOV52b   --               NOV52c   --               NOV52d   --               NOV52e   --               NOV52f   --               NOV52g   ST               NOV52h   --                  
 
      Further analysis of the NOV52a protein yielded the following properties shown in Table 52C.  
               TABLE 52C                       Protein Sequence Properties NOV52a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 8; pos. chg 1; neg. chg 1           H-region:   length 6; peak value −6.21           PSG score:   −10.61                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −9.40           possible cleavage site: between 45 and 46                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 3           Number of TMS(s) for threshold 0.5: 0                             PERIPHERAL   Likelihood = 1.11 (at 629)                         ALOM score: −1.70 (number of TMSs: 0)       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   9.53           Hyd Moment(95):   7.08   G content:   0           D/E content:   2   S/T content:   1                         Score: −6.16       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: RKPK (4) at 1307           pat7: none           bipartite: none           content of basic residues: 8.7%           NLS Score: −0.22       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: found       KIVPEPKQL at 596       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         47.8%: nuclear           30.4%: cytoplasmic           17.4%: mitochondrial            4.3%: vesicles of secretory system                 &gt;&gt; prediction for CG59584-03 is nuc (k = 23)                  
 
      A search of the NOV52a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 52D.  
               TABLE 52D                          Geneseq Results for NOV52a                                         NOV52a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value                                             ABU52373   Human GPCR related protein   158 . . . 1593   1436/1436   (100%)   0.0           NOV26b -  Homo sapiens , 1436 aa.    1 . . . 1436   1436/1436   (100%)           [WO200279398-A2, 10-OCT-2002]       ABU52372   Human GPCR related protein   307 . . . 1593   997/1311   (76%)   0.0           NOV26a -  Homo sapiens , 1411 aa.   164 . . . 1411   1072/1311   (81%)           [WO200279398-A2, 10-OCT-2002]       ABG05715   Novel human diagnostic protein   308 . . . 1137   742/852   (87%)   0.0           #5706 -  Homo sapiens , 1200 aa.   30 . . . 819   748/852   (87%)           [WO200175067-A2, 11-OCT-2001]       ABG05716   Novel human diagnostic protein   393 . . . 1137   655/767   (85%)   0.0           #5707 -  Homo sapiens , 1379 aa.   294 . . . 998    662/767   (85%)           [WO200175067-A2, 11-OCT-2001]       AAU81018   Human alpha2 macroglobulin   306 . . . 1589   527/1320   (39%)   0.0           (alpha2M) receptor #1 mature protein -   144 . . . 1445   798/1320   (59%)             Homo sapiens , 1451 aa.           [WO200192474-A1, 06-DEC-2001]                  
 
      In a BLAST search of public sequence databases, the NOV52a protein was found to have homology to the proteins shown in the BLASTP data in Table 52E.  
               TABLE 52E                          Public BLASTP Results for NOV52a                                         NOV52a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               P20740   Ovostatin precursor   306 . . . 1584   577/1306 (44%)   0.0           (Ovomacroglobulin) -  Gallus gallus     178 . . . 1461   844/1306 (64%)           (Chicken), 1473 aa.       P01023   Alpha-2-macroglobulin precursor   306 . . . 1589   527/1320 (39%)   0.0           (Alpha-2-M) -  Homo sapiens     167 . . . 1468   798/1320 (59%)           (Human), 1474 aa.       CAA01532   ALPHA 2-MACROGLOBULIN 690-   306 . . . 1589   525/1320 (39%)   0.0           730 -  Homo sapiens  (Human), 1474   167 . . . 1468   795/1320 (59%)           aa.       CAA01533   ALPHA 2-MACROGLOBULIN 690-   306 . . . 1589   524/1330 (39%)   0.0           740 -  Homo sapiens  (Human), 1484   167 . . . 1478   792/1330 (59%)           aa.       P06238   Alpha-2-macroglobulin precursor   306 . . . 1590   520/1314 (39%)   0.0           (Alpha-2-M) -  Rattus norvegicus     170 . . . 1467   782/1314 (58%)           (Rat), 1472 aa.                  
 
      PFam analysis predicts that the NOV52a protein contains the domains shown in the Table 52F.  
               TABLE 52F                          Domain Analysis of NOV52a                                     Identities/                   Similarities       Pfam   NOV52a Match   for the       Domain   Region   Matched Region   Expect Value               A2M_N   110 . . . 763   171/707 (24%)   6e−62               420/707 (59%)       A2M    852 . . . 1584   258/858 (30%)   3.9e−146               503/858 (59%)                  
 
     Example 53  
      The NOV53 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 53A.  
               TABLE 53A                       NOV53 Sequence Analysis                                                NOV53a, 56008-01   SEQ ID NO:1107   3445 bp           DNA Sequence   ORF Start: ATG at 117   ORF Stop: TGA at 2381                       CACCGCGTGTTCGCGCCTGGTAGAGATTTCTCGAAGACACCAGTGGGCCCGTGTGGAACC               AAACCTGCGCGCGTGGCCGGGCCGTGGGACAACGAGGCCGCGGAGACGAAGGCGCA   ATG G       CGAGGAAGTTATCTGTAATCTTGATCCTGACCTTTGCCCTCTCTGTCACAAATCCCCTTC       ATGAACTAAAAGCAGCTGCTTTCCCCCAGACCACTGAGAAAATTAGTCCGAATTGGGAAT       CTGGCATTAATGTTGACTTGGCAATTTCCACACGGCAATATCATCTACAACAGCTTTTCT       ACCGCTATGGAGAAAATAATTCTTTGTCAGTTGAAGGGTTCAGAAAATTACTTCAAAATA       TAGGCATAGATAAGATTAAAAGAATCCATATACACCATGACCACGACCATCACTCAGACC       ACGAGCATCACTCAGACCATGAGCGTCACTCAGACCATGAGCATCACTCAGAGCACGAGC       ATCACTCTGACCATGATCATCACTCTCACCATAATCATGCTGCTTCTGGTAAAAATAAGC       GAAAAGCTCTTTGCCCAGACCATGACTCAGATAGTTCAGGTAAAGATCCTAGAAACAGCC       AGGGGAAAGGAGCTCACCGACCAGAACATGCCAGTGGTAGAAGGAATGTCAAGGACAGTG       TTAGTGCTAGTGAAGTGACCTCAACTGTGTACAACACTGTCTCTGAAGGAACTCACTTTC       TAGAGACAATAGAGACTCCAAGACCTGGAAAACTCTTCCCCAAAGATGTAAGCAGCTCCA       CTCCACCCAGTGTCACATCAAAGAGCCGGGTGAGCCGGCTGGCTGGTAGGAAAACAAATG       AATCTGTGAGTGAGCCCCGAAAAGGCTTTATGTATTCCAGAAACACAAATGAAAATCCTC       AGGAGTGTTTCAATGCATCAAAGCTACTGACATCTCATGGCATGGGCATCCAGGTTCCGC       TGAATGCAACAGAGTTCAACTATCTCTGTCCAGCCATCATCAACCAAATTGATGCTAGAT       CTTGTCTGATTCATACAAGTGAAAAGAAGGCTGAAATCCCTCCAAAGACCTATTCATTAC       TGGCACTGGCCGTTGGGACTTTGAGTGGTGATGCTTTTTTACACCTTCTTCCACATTCTC       ATGCAAGTCACCACCATAGTCATAGCCATGAAGAACCAGCAATGGAAATGAAAAGAGGAC       CACTTTTCAGTCATCTGTCTTCTCAAAACATAGAAGAAAGTGCCTATTTTGATTCCACGT       GGAAGGGTCTAACAGCTCTAGGAGGCCTGTATTTCATGTTTCTTGTTGAACATGTCCTCA       CATTGATCAAACAATTTAAAGATAAGAAGAAAAAGAATCAGAAGAAACCTGAAAATGATG       ATGATGTGGAGATTAAGA2GCAGTTGTCCAAGTATGAATCTCAACTTTCAACAAATGAGG       AGAAAGTAGATACAGATGATCGAACTGAAGGCTATTTACGAGCAGACTCACAAGAGCCCT       CCCACTTTGATTCTCAGCAGCCTGCAGTCTTGGAAGAAGAAGAGGTCATGATAGCTCATG       CTCATCCACAGGAAGTCTACAATGAATATGTACCCAGAGGGTGCAAGAATAAATGCCATT       CACATTTCCACGATACACTCGGCCAGTCAGACGATCTCATTCACCACCATCATGACTACC       ATCATATTCTCCATCATCACCACCACCAAAACCACCATCCTCACAGTCACAGCCAGCGCT       ACTCTCGGGAGGAGCTGAAAGATGCCGGCGTCGCCACTCTGGCCTGGATGGTGATAATGG       GTGATGGCCTGCACAATTTCAGCGATGGCCTAGCAATTGGTGCTGCTTTTACTGAAGGCT       TATCAAGTGGTTTAAGTACTTCTGTTGCTGTGTTCTGTCATGAGTTGCCTCATGAATTAG       GTGACTTTGCTGTTCTACTAAAGGCTGGCATGACCGTTAAGCAGGCTGTCCTTTATAATG       CATTGTCAGCCATGCTGGCGTATCTTGGAATGGCAACAGGAATTTTCATTGGTCATTATG       CTGAAAATGTTTCTATGTGGATATTTGCACTTACTGCTGGCTTATTCATGTATGTTGCTC       TGGTTGATATGGTACCTGAAATGCTGCACAATGATGCTAGTGACCATGGATGTAGCCGCT       GGGGGTATTTCTTTTTACAGAATGCTGGGATGCTTTTGGGTTTTGGAATTATGTTACTTA       TTTCCATATTTGAACATAAAATCGTGTTTCGTATAAATTTC   TAG TTAAGGTTTAAATGCT           AGAGTAGCTTAAAAAGTTGTCATAGTTTCAGTAGGTCATAGGGAGATGAGTTTGTATGCT           GTACTATGCAGCGTTTAAAGTTAGTGGGTTTTGTGATTTTTGTATTGAATATTGCTGTCT           GTTACAAAGTCAGTTAAAGGTACGTTTTAATATTTAAGTTATTCTATCTTGGAGATAAAA           TCTGTATGTGCAATTCACCGGTATTACCAGTTTATTATGTAAACAAGAGATTTGGCATGA           CATGTTCTGTATGTTTCAGGGAAAAATGTCTTTAATGCTTTTTCAAGAACTAACACAGTT           ATTCCTATACTGGATTTTAGGTCTCTGAAGAACTGCTGGTGTTTAGGAATAAGAATGTGC           ATGAAGCCTAAAATACCAAGAAAGCTTATACTGAATTTAAGCAAAGAAATAAAGGAGAAA           AGAGAAGAATCTGAGAATTGGGGAGGCATAGATTCTTATAAAAATCACAAAATTTGTTGT           AAATTAGAGGGGAGAAATTTAGAATTAAGTATAAAAAGGCAGAATTAGTATAGAGTACAT           TCATTAAACATTTTTGTCAGGATTATTTCCCGTAAAAACGTAGTGAGCACTTTTCATATA           CTAATTTAGTTGTACATTTAACTTTGTATAATACAGAAATCTAAATATATTTAATGAATT           CAAGCAATATATCACTTGACCAAGAAATTGGAATTTCAAAATGTTCGTGCGGGTATATAC           CAGATGAGTACAGTGAGTAGTTTTATGTATCACCAGACTGGGTTATTGCCAAGTTATATA           TCACCAAAAGCTGTATGACTGGATGTTCTGGTTACCTGGTTTACAAAATTATCAGAGTAG           TAAAACTTTGATATATATGAGGATATTAAAACTACACTAAGTATCATTTGATTCGATTCA           GAAAGTACTTTGATATCTCTCAGTGCTTCAGTGCTATCATTGTGAGCAATTGTCTTTTAT           ATACGGTACTGTAGCCATACTAGGCCTGTCTGTGGCATTCTCTAGATGTTTCTTTTTTAC           ACAATAAATTCCTTATATCAGCTTG                                       NOV53a, CG56008-01   SEQ ID NO:1108   775 aa           Protein Sequence                     MARKLSVILILTFALSVTNPLHELKAAAFPQTTEKISPNWESGINVDLAISTRQYHLQQL           FYRYGENNSLSVEGFRKLLQNIGIDKIKRIHIHHDHDHHSDHEHHSDHERHSDHEHHSEH       EHHSDHDHHSHHNHAASGKNKRKALCPDHDSDSSGKDPRNSQGKGAHRPEHASGRRNVKD       SVSASEVTSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRLAGRKT       NESVSEPRKGFMYSRNTNENPQECFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDA       RSCLIHTSEKKAEIPPKTYSLQTAWVGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSF       LVALAVGTLSGDAFLHLLPHSHASHHHSHSHEEPAMEMKRGPLFSHLSSQNIEESAYFDS       TWKGLTALGGLYFMFLVEHVLTLIKQFKDKKKKNQKKPENDDDVEIKKQLSKYESQLSTN       EEKVDTDDRTEGYLRADSQEPSHFDSQQPAVLEEEEVMIAHAHPQEVYNEYVPRGCKNKC       HSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQRYSREELKDAGVATLAWMVI       MGDGLHNFSDGLAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVLLKAGMTVKQAVLY       NALSAMLAYLGMATGIFIGHYAENVSMWIFALTAGLFMYVALVDMVPENLHNDASDHGCS       RWGYFFLQNAGMLLGFGIMLLISIFEHKIVFRINF                  
 
      Further analysis of the NOV53a protein yielded the following properties shown in Table 53B.  
               TABLE 53B                       Protein Sequence Properties NOV53a                                        SignalP analysis:   Cleavage site between residues 18 and 19       PSORT II analysis:                         Results Summary:       plasma membrane --- Certainty = 0.6400(Affirmative) &lt; succ&gt;       Golgi body --- Certainty = 0.4600(Affirmative) &lt; succ&gt;       endoplasmic reticulum (membrane) --- Certainty =       0.3700(Affirmative) &lt; succ&gt;       endoplasmic reticulum (lumen) --- Certainty =       0.1000(Affirmative) &lt; succ&gt;       Reasoning Steps:       &gt;&gt;&gt;  MUS  belongs to the animal class       *** Reasoning Step: 2                     SRCFLG:   1                 Prelim. Calc. of ALOM (thresh: 0.5) count: 7                     mostN:   5 at i = 4                     MTOP program   Imiddle: 12 Chg diff(C-N): −2.5                     McG:   Length of UR: 17           Peak Value of UR: 3.09           Net Charge of CR: 2       McG:   Discrim Score: 9.90       GvH:   Signal Score (−3.5): 2.04           Possible site: 20                 &gt;&gt;&gt; Seems to have a cleavable N-term signal seq.       Amino Acid Composition: calculated from 21       involving clv.sig in the ALOMREC or not: 1B                     ALOM program   count: 6 value: −11.15 threshold: 0.5                                 INTEGRAL   Likelihood =   Transmembrane               −11.15   324-340 (313-348)           INTEGRAL   Likelihood =   Transmembrane                −5.26   346-362 (342-369)           INTEGRAL   Likelihood =   Transmembrane                −4.73   681-697 (679-701)           INTEGRAL   Likelihood =   Transmembrane                −2.44   725-741 (723-742)           INTEGRAL   Likelihood =   Transmembrane                −1.97   656-672 (656-673)           INTEGRAL   Likelihood =   Transmembrane                −1.59   422-438 (421-438)                             PERIPHERAL   Likelihood =  3.45                         modified ALOM score: 2.83                 &gt;&gt;&gt; Likely a Type IIIa membrane protein (clv)                     Gavel:   Bound.Mitoch.Preseq. R-2 motif: 5 ARKLSV           mtdisc (mit) Status: positive (3.31)                 *** Reasoning Step: 3                     KDEL   Count: 0                 2nd signal for mitochondria (apolar)(5)                         from: 5 to: 17 Score: 8.5                 SKL motif: pos: 399(752), count: 3 SHL       pox modified by SKL scr: 0.1                     Poxaac   Score: 2.67           aac not from the N-term. scr modified                 &gt;&gt;&gt; POX Status: notclr       &gt;&gt;&gt; lys: −1.27 Status: negative       Nuc-4 pos: 443 (5) KKKK       &gt;&gt;&gt; Nuclear Signal. Status: negative (0.00)                  
 
      A search of the NOV53a protein against the Geneseq and public databases, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 53C. In a BLAST search of public sequence databases, the NOV53a protein was found to have homology to the proteins shown in the BLASTP data in Table 53D.  
               TABLE 53C                          Geneseq and Public Results for NOV53a                                         NOV53a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               AAM51198   Human breast cancer 4 gene   32 . . . 773   735/742 (99%)               (BCR4)-encoded    1 . . . 736   736/742 (99%)       Q13433   ESTROGEN REGULATED LIV-1   32 . . . 786   748/755 (99%)           PROTEIN.    1 . . . 749   749/755 (99%)       AAE07205   Human LIV-1 protein   32 . . . 773   735/742 (99%)                1 . . . 736   736/742 (99%)                  
 
      PFam analysis predicts that the NOV53a protein contains the domains shown in the Table 53E.  
               TABLE 53E                          Domain Analysis of NOV53a                                             Score for                   NOV53a Match   the Matched   Expect           Pfam Domain   Region   Region   Value                                                 Peptidase_C4   251 . . . 266   4.6   3.4e−56           Osteopontin    4 . . . 300   −85.1   0.95                      
 
     Example 54  
      The NOV54 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 54A.  
               TABLE 54A                       NOV54 Sequence Analysis                                                +TL,1NOV54a, CG59905-01   SEQ ID NO:1109   3145 bp           DNA Sequence   ORF Start: ATG at 34   ORF Stop: TGA at 3046                               ATTTTACTTGCTGGATCTTCAGCCTTGACCTGT   ATG GCAAATGGCTTATGGGACCGATCCCTGCCCAA               GTGTTTGGCTATATCCTGTGGACACCCAGGGGTCCCTGCCAACGCCGTCCTCACTGGAGAGCTGTTTA           CCTATGGCGCCGTCGTGCACTACTCCTGCAGAGGGAGCGAGAGCCTCATAGGCAACGACACGAGAGTG           TGCCAGGAAGACAGTCACTGGAGCGGGGCACTGCCCCACTGCACAGGAAATAATCCTGGATTCTGTGG           TGATCCGGGGACCCCAGCACATGGGTCTCGGCTTGGTGATGACTTTAAGACAAAGAGTCTTCTCCGCT           TCTCCTGTGAAATGGGGCACCAGCTGAGGGGCTCCCCTGAACGCACGTGTTTGCTCAATGGGTCATGG           TCAGGACTGCAGCCGGTGTGTGAGGCCGTGTCCTGTGGCAACCCTGGCACACCCACCAACGGAATGAT           TGTCAGTAGTGATGGCATTCTGTTCTCCAGCTCGGTCATCTATGCCTGCTGGGAAGGCTACAAGACCT           CAGGGCTCATGACACGGCATTGCACAGCCAATGGGACCTGGACAGGCACTGCTCCCGACTGCACAATT           ATAAGTTGTGGGGATCCAGGCACACTAGCAAATGGCATCCAGTTTGGGACCGACTTCACCTTCAACAA           GACTGTGAGCTATCAGTGTAACCCAGGCTATGTCATGGAAGCAGTCACATCCGCCACTATTCGCTGTA           CCAAAGACGGCAGGTGGAATCCGAGCAAACCTGTCTGCAAAGCCGTGCTGTGTCCTCAGCCGCCGCCG           GTGCAGAATGGAACAGTGGAGGGAAGTGATTTCCGCTGGGGCTCCAGCATAAGTTACAGCTGCATGGA           CGGTTACCAGCTCTCTCACTCCGCCATCCTCTCCTGTGAAGGTCGCGGGGTGTGGAAAGGAGAGATCC           CCAGTGTCTGCCTGTGTTCTGCGGAGACCCTGGCATCCCCGCAGAAGGGCGACTTAGTGGGAAAAGTT           TCACCTATAAGTCCGAAGTCTTCTTCCAGTGCAAATCTCCATTTATACTCGTGGGATCCTCCAGAAGA           GTCTGCCAAGCTGACGGCACGTGGAGCGGCATACAACCCACCTGCATTGGTAATAATTATCATACAGC           TCTGGGGATACCTGGGAGTATTTGGAGATGAGGACGCTTCATTCCGAAATTGGGTCATTTGTGATTAC           ATAGAAAGTGTTTCCATAGACAGTTTTCTGTACAAGGTTGGAAGCACGGTTTTTTTCAGGTGCAGAAA           AGGCTACCATATTCAAGGTTCCACGACTCGCACCTGCCTTGCCAATTTAACATGGAGTGGGATACAGA           CCGAATGTATACCTCATGCCTGCAGACAGCCAGAAACCCCGGCACACGCGGATGTGAGAGCCATCGAT           CTTCCTACTTTCGGCTACACCTTAGTGTACACCTGCCATCCAGGCTTTTTCCTCGCAGGGGGATCTGA           GCACAGAACATGTAAAGCAGACATGAAATGGACAGGAAAGTCGCCTGTGTGTAAAATTCCTTCAGATG           TCTTTTTCGTCAATTCACTGTGGAAGGGGTATTATGAATATTTAGGGAAAAGACAACCCGCCACTCTA           ACTGTTGACTGGTTCAATGCAACAAGCAGTAAGGTGAATGCCACCTTCAGCGAAGCCTCGCCAGTGGA           GCTGAAGTTGACAGGCATTTACAAGAAGGAGGAGGCCCACTTACTCCTGAAAGCTTTTCAAATTAAAG           GCCAGGCAGATATTTTTGTAAGCAAGTTCGAAAATGACAACTGGGGACTAGATGGTTATGTGTCATCT           GGACTTGAAAGAGGAGGATTTACTTTTCAAGGTGACATTCATGGAAAAGACTTTGGAAAATTTAAGCT           AGAAAGGCAAGGATGGGTCACAATATTCTTGAGCCTATTTCTTCATCTTAAATCTCAGTATAGAAGTT           CCCAAGGTTGTTACGAGATTGAGAGGCCACATCCTTTAAACCCAGATCAAGACTCTTCCAGTCATTAC           CACGGCACCAGCAGTGGCTCTGTGGCGGCTGCCATTCTGGTTCCTTTCTTTGCTCTAATTTTATCAGG           GTTTGCATTTTACCTCTACAAACACAGAACGAGACCAAAAGTTCAATACAATGGCTATGCTGGGCATG           AAAACAGCAATGGACAAGCATCGTTTGAAAACCCCATGTATGATACAAACTTAAAACCCACAGAAGCC           AAGGCTAAAACCACACACGGGCTGCTCACGTCTCTGGACTCCAAGAGAAAGATGGTTATAACCCTGGC           AGAGTCTTTACCCGCCCTGCGAACCTGCCTGTTGATCTGCTTCCCACTCCTCTTTAGACTTGCTCGTG           AATCTTCAGCACAGCCATTTGTTTTGAGTATTCAAACACATAAAAAGATATCTGGCAACTTCCCACTT           CTTATGACTTCTCAGACACCTTGTAACGGAGCTTCCCTTGGAGGTGGACAAACTTCTCACTCACAAGA           GAGACGGAGAGCAACAGAGAGAGATGGGCAGGGATTGATTCGAGGATTGGCTGACTCGATTATGGAGG           GTGAGAAGTCCCAGGACAGGCCGTCTGCAAGGCGTAAACCCAGGGAAGCTGCTGGTATGGCTCGGTTC           AAGTCCAAAGGCCTCAGCACCAAGGAAACCAAGGTGATAACTCTCAGTTCGGGTCAAAGTCCTGGGAG           TCTGCAAGGCCTCTCATTGAGTAAGTCTCACAAGATCCGATGGTTTTATAAAGGGCAGTTCCCCTGCA           CAAGCTCTCTTCTCTGCCACCACGCGTTTGCTGTTCATTCACCTTTCACCATGATTGTGAGGCCTCCC           AGCCATGTGGAACTGTGCAAAGAGGATGTTCAAAGGGCATCTTGGACCAGGAGGAGGAAGCCCATTGT           GAGGATGGCAAAGAACAATAAATGGAAGGCCCGTGGAACCCTGAGCGGCTGCCCCATCACTGTCCTCT           CCATCCTTTCCATGCTTCCCATGGTGCATGGCTCTCAGGCTCTCCAAGCACCA TGA   GCTCCTGGCGCG               TATGGCCTGGCCCCTGAGTGTGGAGTCTGTGGACTTTAAATGTGCCTTTACTCAGCCAGCATCTCCCT               GCTGGGTGCGATGTTG                                               NOV54a, CG59905-01   SEQ ID NO:1110   1004 aa   MW at 109752.7 kD           Protein Sequence                             MANGLWDRSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGAL               PHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVS           CGNPGTPTNGMIVSSDGTLFSSSVTYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLAN           GIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDF           RWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPSVCLCSAETLASPQKGDLVGKVSPISPKSSSSA           NLHLYSWDPPEESAKLTARGAAYNPPALVIIIIQLWGYLGVFGDEDASFRNWVICDYIESVSIDSFLY           KVGSTVFFRCRKGYEIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYT           CHPGFFLAGGSEHRTCKADMKWTGKSPVCKIPSDVFFVNSLWKGYYEYLGKRQPATLTVDWFNATSSK           VNATFSEASPVELKLTGIYKKEEAHLLLKAFQIKGQADIFVSKFENDNWGLDGYVSSGLERGGFTFQG           DIHGKDFGKFKLERQGWVTIFLSLFLHLKSQYRSSQGCYEIERPHPLNPDQDSSSHYHGTSSGSVAAA           ILVPFFALILSGFAFYLYKHRTRPKVQYNGYAGHENSNGQASFENPMYDTNLKPTEAKAKTTHGLLTS           LDSKRKMVITLAESLPALRTCLLICFPLLFRLARESSAQPFVLSIQTHKKISGNFPLLMTSQTPCNGA           SLGGGQTSHSQERRRATERDGQGLIRGLADSIMEGEKSQDRPSARRKPREAAGMARFKSKGLSTKETK           VITLSSGQSPGSLQGLSLSKSHKIRWFYKGQFPCTSSLLCHHAFAVHSPFTMIVRPPSHVELCKEDVQ           RASWTRRRKPIVRMAKNNKWKARGTLSGCPITVLSTLSMLPMVHGSQALQAP                                         NOV54b, CG59905-03   SEQ ID NO:1111   10989 bp           DNA Sequence   ORF Start: ATG at 286   ORF Stop: TGA at 10987                               CCTTCCTGCCCGGCTCGGCCGGCGCTCGTCCCCGGCCCCGGCCCCGCCAGCCCGGGTCTCCGCGCTCG                   GAGCAGCTCAGCCCTGCAGTGGCTCGGGACCCGATGCTATGAGAGGGAAGCGAGCCGGGCGCCCAGAC               CTTCAGGAGGCGTCGGATGCGCGGCGGGTCTTGGGACCGGGCTCTCTCTCCGGCTCGCCTTGCCCTCG               GGTGATTATTTGGCTCCGCTCATAGCCCTGCCTTCCTCGGAGGAGCCATCGGTGTCGCGTGCGTGTGG               AGTATCTGCAGAC   ATG ACTGCGTGGAGGAGATTCCAGTCGCTGCTCCTGCTTCTCGGGCTGCTGGTGC           TGTGCGCGAGGCTCCTCACTGCAGCGAAGGGTCAGAACTGTGGAGGCTTAGTCCAGGGTCCCAATGGC           ACTATTGAGAGCCCAGGGTTTCCTCACGGGTATCCGAACTATGCCAACTGCACCTGGATCATCATCAC           GGGCGAGCGCAATAGGATACAGTTGTCCTTCCATACCTTTGCTCTTGAAGAAAATTTTGATATTTTAT           CAGTTTACGATGGACAGCCTCAACAAGGGAATTTAAAAGTGAGATTATCGGGATTTCAGCTGCCCTCC           TCTATAGTGAGTACAGGATCTATCCTCACTCTGTGGTTCACGACAGACTTCGCTGTGAGTGCCCAAGG           TTTCAAAGCATTATATGAAGTTTTACCTAGCCACACTTGTGGAAATCCTGGAGAAATCCTGAAAGGAG           TTCTGCATGGAACGAGATTCAACATAGGAGACAAAATCCGGTACAGCTGCCTCCCTGGCTACATCTTG           GAAGGCCACGCCATCCTGACCTGCATCGTCAGCCCAGGAAATGGTGCATCGTGGGACTTCCCAGCTCC           CTTTTGCAGAGCTGAGGGAGCCTGCGGAGGAACCTTACGCGGGACCAGCAGCTCCATCTCCAGCCCGC           ACTTCCCTTCAGAGTACGAGAACAACGCGGACTGCACCTGGACCATTCTGGCTGAGCCCGGGGACACC           ATTGCGCTGGTCTTCACTGACTTTCAGCTAGAAGAAGGATATGATTTCTTAGAGATCAGTGGCACGGA           AGCTCCATCCATATGGCTAACTGGCATGAACCTCCCCTCTCCAGTTATCAGTAGCAAGAATTGGCTAC           GACTCCATTTCACCTCTGACAGCAACCACCGACGCALAGGATTTAACGCTCAGTTCCAAGTGAAAAAG           GCGATTGAGTTGAAGTCAAGAGGAGTCAAGATGCTGCCCAGCAAGGATGGAAGCCATAAAAACTCTGT           CTTGAGCCAAGGAGGTGTTGCATTGGTCTCTCACATGTGTCTAGATCCTGGGATTCCAGAAAATGGTA           GAAGAGCAGGTTCCGACTTCAGTAGGGTTGGTGCAAATGTACAGTTTTCATGTGAGGACAATTACGTG           CTCCAGGGATCTAAAAGCATCACCTGTCAGAGAGTTACAGAGACGCTCGCTGCTTGGAGTGACCACAG           GCCCATCTGCCGAGCGAGAACATGTGGATCCAATCTGCGTGGGCCCAGCGGCGTCATTACCTCCCCTA           ATTATCCGGTTCAGTATGAAGATAATGCACACTGTGTGTGGGTCATCACCACCACCGACCCGGACAAG           GTCATCAAGCTTGCCTTTGAAGAGTTTGAGCTGGAGCGAGGCTATGACACCCTGACGGTTGGTGATGC           TGGGAAGGTGGGAGACACCAGATCGGTCTTGTACGTGCTCACGGGATCCAGTGTTCCTGACCTCATTG           TGAGCATGAGCAACCAGATGTGGCTACATCTGCAGTCGGATGATAGCATTGGCTCACCTGGGTTTAAA           GCTGTTTACCAAGAAATTGAAAAGGGAGGGTGTGGGGATCCTGGAATCCCCGCCTATGGGAAGCGGAC           GGGCAGCAGTTTCCTCCATGGAGATACACTCACCTTTGAATGCCCGGCGGCCTTTGAGCTGGTGGGGG           AGAGAGTTATCACCTGTCAGCAGAACAATCAGTGGTCTGGCAACAAGCCCAGCTGTGTATTTTCATGT           TTCTTCAACTTTACGGCATCATCTGGGATTATTCTGTCACCAAATTATCCAGAGGAATATGGGAACAA           CATGAACTGTGTCTGGTTGATTATCTCGGAGCCAGGAAGTCGAATTCACCTAATCTTTAATGATTTTG           ATGTTGAGCCTCAATTTGACTTTCTCGCGGTCAAGGATAATGGCATTTCTGACATAACTGTCCTGGGT           ACTTTTTCTGGCAATGAAGTGCCTTCCCAGCTGGCCAGCAGTGGGCATATAGTTCGCTTGGAATTTCA           GTCTGACCATTCCACTACTGGCAGAGGGTTCAACATCACTTACACCACATTTGGTCAGAATGAGTGCC           ATGATCCTGGCATTCCTATAAACGGACGACGTTTTGGTGACAGGTTTCTACTCGGGAGCTCGGTTTCT           TTCCACTGTGATGATGGCTTTGTCAAGACCCAGGGATCCGAGTCCATTACCTGCATACTGCAAGACGG           GAACGTGGTCTGGAGCTCCACCGTGCCCCGCTGTGAAGCTCCATGTGGTGGACATCTGACAGCGTCCA           GCGGAGTCATTTTGCCTCCTGGATGGCCAGGATATTATAAGGATTCTTTACATTGTGAATGGATAATT           GAAGCAAAACCAGGCCACTCTATCAAAATGACTTTTGACAGATTTCAGACAGAGGTCAATTATGACAC           CCCAGTTCCTCATCAGCACCGGGAACTTCATGTACCTGCTGTTCACCACTGACAACAGCCGCTCCAGC           ATCGGCTTCCTCATCCACTATGAGAGTGTGACGCTTGAGTCGGATTCCTGCCTGGACCCGGGCATCCC           TGTGAACGGCCATCGCCACGGTGGAGACTTTGGCATCAGGTCCACAGTGACTTTCAGCTGTGACCCGG           GGTACACACTAAGTGACGACGAGCCCCTCGTCTGTGAGAGGAACCACCAGTGGAACCACGCCTTGCCC           AGCTGCGACGCTCTATGTGGAGGCTACATCCAAGGGAAGAGTGGAACAGTCCTTTCTCCTGGGTTTCC           AGATTTTTATCCAAACTCTCTAAACTGCACGTGGACCATTGAAGTGTCTCATGGGAAAGGAGTTCAAA           TGCTCTTTCACACCTTTCATCTTGAGAGTTCCCACGACTATTTACTGATCACAGAGGATGGAAGTTTT           TCCGAGCCCGTTGCCAGGCTCACCGGGTCGGTGTTGCCTCATACGATCAAGGCAGGCCTGTTTGGAAA                       CTTCACTGCCCAGCTTCGGTTTATATCAGACTTCTCAATTTCGTACGAGGGCTTCAATATCACATTTT           CAGAATATGACCTGGAGCCATGTGATGATCCTGGAGTCCCTGCCTTCAGCCGAAGAATTGGTTTTCAC           TTTGGTGTGGGAGACTCTCTGACGTTTTCCTGCTTCCTGGGATATCGTTTAGAAGGTGCCACCAAGCT           TACCTGCCTGGGTGGGGGCCGCCGTGTGTGGAGTGCACCTCTGCCAAGGTGTGTGGCCGAATGTGGAG           CAAGTGTCAAAGGAAATGAAGGAACATTACTGTCTCCAAATTTTCCATCCAATTATGATAATACCCAT           GAGTGTATCTATAAAATAGAAACAGAAGCCGGCAAGGGCATCCACCTTAGAACACGAAGCTTCCAGCT           GTTTGAAGGAGATACTCTAAAGGTATATGATGGAAAAGACAGTTCCTCACGTCCACTGGGCACGTTCA           CTAAAAATGAACTTCTGGGGCTGATCCTAAACAGCACATCCAATCACCTATGGCTAGAGTTCAACACC           AATGGATCTGACACCGACCAAGGTTTTCAACTCACCTATACCAGTTTTGATCTGGTAAAATGTGAGGA           TCCGGGCATCCCTAACTACGGCTATAGGATCCGTGATGAAGGCCACTTTACCGACACTGTAGTTCTGT           ACAGTTGCAACCCGGGGTACGCCATGCATGGCAGCAACACCCTGACCTGTTTGAGTGGAGACAGGAGA           GTGTGGGACAAACCACTACCTTCGTGCATAGCGGAATGTGGTGGTCAGATCCATGCAGCCACATCAGG           ACGAATATTGTCCCCTGGCTATCCAGCTCCGTATGACAACAACCTCCACTGCACCTGGATTATAGAGG           CAGACCCAGGAAAGACCATTAGCCTCCATTTCATTGTTTTCGACACGGAGATGGCTCACGACATCCTC           AAGGTCTGGGACGGGCCGGTGGACAGTGACATCCTGCTGAAGGAGTGGAGTGGCTCCGCCCTTCCGGA           GGACATCCACAGCACCTTCAACTCACTCACCCTGCAGTTCGACAGCGACTTCTTCATCAGCAAGTCTG           GCTTCTCCATCCAGTTCTCCACCTCAATTGCAGCCACCTGTAACGATCCAGGTATGCCCCAAAATGGC           ACCCGCTATGGAGACAGCAGAGAGGCTGGAGACACCGTCACATTCCAGTGTGACCCTGGCTATCAGCT           CCAAGGACAAGCCAAAATCACCTGTGTGCAGCTGAATAACCGGTTCTTTTGGCAACCAGACCCTCCTA           CATGCATAGCTGCTTGTGGAGGGAATCTGACGGGCCCAGCAGGTGTTATTTTGTCACCCAACTACCCA           CAGCCGTATCCTCCTGGGAAGGAATGTGACTGGAGAGTAAAAGTGAACCCGGACTTTGTCATCGCCTT           GATATTCAAAAGTTTCAACATGGAGCCCAGCTATGACTTCCTACACATCTATGAAGGGGAAGATTCCA           ACAGCCCCCTCATTGGGAGTTACCAGGGCTCTCAGGCCCCAGAAAGAATAGAGAGTAGCGGAAACAGC           CTGTTTCTGGCATTTCGGAGTGATGCCTCCGTGGGCCTTTCAGGGTTCGCCATTGAATTTAAAGAGAA           ACCACGGGAAGCTTGTTTTGACCCAGGAAATATAATGAATGGGACAAGAGTTGGAACAGACTTCAAGC           TTGGCTCCACCATCACCTACCAGTGTGACTCTGGCTATAAGATTCTTGACCCCTCATCCATCACCTGT           GTGATTGGGGCTGATGGGAAACCCTCCTGGGACCAAGTGCTGCCCTCCTGCAATGCTCCCTGTGGAGG           CCAGTACACGGGATCAGAAGGGGTAGTTTTATCACCAAACTACCCCCATAATTACACAGCTGGTCAAA           TATGCCTCTATTCCATCACGGTACCAAAGGAATTCGTGGTCTTTGGACAGTTTGCCTATTTCCAGACA           GCCCTGAATGATTTGGCAGAATTATTTGATGGAACCCATGCACAGGCCAGACTTCTCAGCTCACTCTC           GGGGTCTCACTCAGGGGAAACATTGCCCTTGGCTACGTCAAATCAAATTCTGCTCCGATTCAGTGCAA           AGAGCGGTGCCTCTGCCCGCGGCTTCCACTTCGTGTATCAAGCTGTTCCTCGTACCAGTGACACCCAA           TGCAGCTCTGTCCCCGAGCCCAGATACGGAAGGAGAATTGGTTCTGAGTTTTCTGCCGGCTCCATCGT           CCGATTCGAGTGCAACCCGGGATACCTGCTTCAGGGTTCCACGGCGCTCCACTGCCAGTCCGTGCCCA           ACGCCTTGGCACAGTGGAACGACACGATCCCCAGCTGTGTGGTACCCTGCAGTGGCAATTTCACTCAA           CGAAGAGGTACAATCCTGTCCCCCGGCTACCCTGAGCCATACGGAAACAACTTGAACTGTATATGGAA           GATCATAGTTACGGAGGGCTCGGGAATTCAAGATCCAAGTGATCAGTTTTGCCACGGAGCAGAACTGG           GACTTCCCTTTGAGATCCACGATGGTGGGGATGTGACCGCACCCAGACTGGGAAGCTTCTCAGGCACC           ACAGTACCGGCACTGCTGAACAGTACTTCCAACCAACTCTACCTGCATTTCCAGTCTGACATTAGTGT           GGCAGCTGCTGGTTTCCACCTGGAATACAAAACTGTAGGTCTTGCTGCATGCCAAGAACCAGCCCTCC           CCAGCAACAGCATCAAAATCGGAGATCGGTACATGGTGAACGACGTGCTCTCCTTCCAGTGCGAGCCC           GGGTACACCCTGCAGGGCCGTTCCCACATTTCCTGTATGCCAGGGACCGTTCGCCGTTGGAACTATCC           GTCTCCCCTGTGCATTGCAACCTGTGGAGGGACGCTGAGCACCTTGGGTGGTGTGATCCTGAGCCCCG           GCTTCCCAGGTTCTTACCCCAACAACTTAGACTGCACCTGGAGGATCTCATTACCCATCGGCTATGGT           GCACATATTCAGTTTCTGAATTTTTCTACCGAAGCTAATCATGACTTCCTTGAAATTCAAAATGGACC           TTACCACACCAGCCCCATGATTGGACAATTTAGCGGCACGGATCTCCCCGCGGCCCTGCTGAGCACAA           CGCATGAAACCCTCATCCACTTTTATAGTGACCATTCGCAAAACCGGCAAGGATTTAAACTTGCTTAC           CAAGCCTATGAATTACAGAACTGTCCAGATCCACCCCCATTTCAGAATGGGTACATGATCAACTCGGA           TTACAGCGTGGGGCAATCAGTATCTTTCGAGTGTTATCCTGGGTACATTCTAATAGGCCATCCTGTCC                       CCACTTGTCAGCATGGGATCAACAGAAACTGGAACTACCCTTTTCCAAGATGTGATGCCCCTTGTGGG           TACAACGTAACTTCTCAGAACGGCACCATCTACTCCCCTGGCTTTCCTGATGAGTATCCGATCCTGAA           GGACTGCATTTGGCTCATCACGGTGCCTCCAGGGCACGGAGTTTACATCAACTTCACCCTGTTACAGA           TTCAGTGGCAACACAGCCCTCGAAACGGCGTATAGCTCCACCAACCAAGTCCTGCTCAAGTTCCACAG           CGACTTTTCAAATGGAGGCTTCTTTGTCCTCAATTTCCACGCATTTCAGCTCAAGAAATGTCAACCTC           CCCCAGCGGTTCCACAGGCAGAAATGCTTACTGAGGATGATGATTTCGAAATAGGAGATTTTGTGAAG           TACCAGTGCCACCCCGGGTACACCTTGGTGGGGACCGACATTCTGACTTGCAAGCTCAGTTCCCAGTT           GCAGTTTGAGGGTTCTCTCCCAACATGTGAAGCACAATGCCCAGCAAATGAAGTCCGGACTGGATCAT           CGGGAGTCATTCTCAGTCCAGGGTATCCGGGTAATTATTTTAACTCCCAGACTTGCTCTTGGAGTATT           ACTGGAAGTGTTTGATGGTTCTTCTGGGCAAAGTCCTCTGCTAGTAGTCTTAAGTGGGAATCATACTG           AACAATCAAATTTTACAAGCAGGAGTAATCAGTTATATCTCCGCTGGTCCACTGACCATGCCACCAGT           AAGAAAGGATTCAAGATTCGCTATGCAGCACCTTACTGCAGTTTGACCCACCCCCTGAAGAATGGGGG           TATTCTAAACAGGACTGCAGGAGCGGTTGGAAGCAAAGTGCATTATTTTTGCAAGCCTGGATACCGAA           TGGTCGGCCACAGCAATGCAACCTGTAGACGAAACCCACTTGGCATGTACCAGTGGGACTCCCTCACG           CCACTCTGCCAGGCTGTGTCCTGTGGAATCCCAGAATCCCCAGGAAACGGTTCATTTACCGGGAACGA           GTTCACTTTGGACAGTAAAGTGGTCTATGAATGTCATGAAGGCTTCAAGCTTGAATCCAGCCAGCAAG           CAACAGCCGTGTGTCM~GAAGATGGGCTGTGGAGTAACAAGGGGAAGCCGCCCATGTGTAAGCCGGTC           GCTTGCCCCAGCATTGAAGCTCAGCTCTCAGAACATGTCATCTGGAGGCTGGTTTCAGGATCCTTGAA           TGAGTACGGTGCTCAAGTATTGCTGAGCTGCAGTCCTGGTTACTACTTAGAAGGCTGGAGGCTCCTGC           GGTGCCAGGCCAATGGGACGTGGAACATAGGAGATGAGAGGCCAAGCTGTCGAGTTATCTCGTGTGGA           AGCCTTTCCTTTCCCCCAAATGGCAACAAGATTGGAACGTTGACAGTTTATGGGGCCACAGCTATATT           TACGTGCAACACCGGCTACACGCTTGTGGGGTCTCATGTCAGAGAGTGCTTGGCAAATGGGCTCTGGA           GCGGCAGCGAAACTCGATGTTTAGCTGGCCACTGCGGTTCCCCAGACCCGATTGTGAACGGTCACATT           AGTGGAGATGGCTTCAGTTACAGAGACACGGTGGTTTACCAGTGCAATCCTGGTTTCCGGCTTGTGGG           AACTTCCGTGAGGATATGCCTGCAAGACCACAAGTGGTCTGGACAAACGCCTGTCTGTGTCCGTATCA           CATGTGGTCACCCTGGAAACCCTGCCCACGGATTCACTAATGGCAGTGAGTTCAACCTGAATGATGTC           GTGAATTTCACCTGCAACACGGGCTATTTGCTGCAGGGCGTGTCTCGAGCCCAGTGTCGGAGCAACGG           CCAGTGGAGTAGCCCTCTGCCCACGTGTCGAGTGGTGAACTGTTCTGATCCAGGCTTTGTGGAAAATG           CCATTCGTCACGGGCAACAGAACTTCCCTGAGAGTTTTGAGTATGGAATGAGTATCCTGTACCATTGC           AAGAAGGGATTTTACTTGCTGGGATCTTCAGCCTTGACCTGTATGGCAAATGGCTTATGGGACCGATC           CCTGCCCAAGTGTTTGGCTATATCGTGTGGACACCCAGGGGTCCCTGCCAACGCCGTCCTCACTGGAG           AGCTGTTTACCTATGGCGCCGTCGTGCACTACTCCTGCAGAGGGAGCGAGAGCCTCATAGGCAACGAC           ACGAGAGTGTGCCAGGAAGACAGTCACTGGAGCGGGGCACTGCCCCACTGCACAGGAAATAATCCTGG           ATTCTGTGGTGATCCGGGGACCCCAGCACATGGGTCTCGGCTTGGTGATGACTTTAAGACAAAGAGTC           TTCTCCGCTTCTCCTGTGAAATGGGGCACCAGCTGAGGGGCTCCCCTGAACGCACGTGTTTGCTCAAT           GGGTCATGGTCAGGACTGCAGCCGGTGTGTGAGGCCGTGTCCTGTGGCAACCCTGGCACACCCACCAA           CGGAATGATTGTCAGTAGTGATGGCATTCTGTTCTCCAGCTCGGTCATCTATGCCTGCTGGGAAGGCT           ACAAGACCTCAGGGCTCATGACACGGCATTGCACAGCCAATGGGACCTGGACAGGCACTGCTCCCGAC           CTTCAACAAGACTGTGAGCTATCAGTGTAACCCAGGCTATGTCATGGAAGCAGTCACATCCGCCACTA           TTCGCTGTACCAAAGACGGCAGGTGGAATCCGAGCAAACCTGTCTGCAAAGCCGTGCTGTGTCCTCAG           CCGCCGCCGGTGCAGAATGGAACAGTGGAGGGAAGTGATTTCCGCTGGGGCTCCAGCATAAGTTACAG           CTGCATGGACGGTTACCAGCTCTCTCACTCCGCCATCCTCTCCTGTGAAGGTCGCGGGGTGTGGAAAG           GAGAGATCCCCCAGTGTCTCGCTGTGTTCTGCGGAGACCCTGGCATCCCCGCAGAAGGGCGACTTAGT           GGGAAAAGTTTCACCTATAAGTCCGAAGTCTTCTTCCAGTGCAAATCTCCATTTATACTCGTGGGATC           CTCCAGAAGAGTCTGCCAAGCTGACGGCACGTGGAGCGGCATACAACCCACCTGCATTGGTGATCCTG                       CTCATAACACCTGCCCAGACCCTGGTACGCCACACTTTGGAATACAGAATAGCTCCAGAGGCTATGAG           GTTGGAAGCACGGTTTTTTTCAGGTGCAGAAAAGGCTACCATATTCAAGGTTCCACGACTCGCACCTG           CCTTGCCAATTTAACATGGAGTGGGATACAGACCGAATGTATACGTCATGCCTGCAGACAGCCAGAAA           CCCCGGCACACGCGGATGTGAGAGCCATCGATCTTCCTACTTTCGGCTACACCTTAGTGTACACCTGC           CATCCAGGCTTTTTCCTCGCAGGGGGATCTGAGCACAGAACATGTAAAGCAGACATGAAATGGACAGG           CTTCAGATGTCTTTTTCGTCAATTCACTGTGGAAGGGGTATTATGAATATTTAGGGAAAAGACAACCC           GCCACTCTAACTGTTGACTGGTTCAATGCAACAAGCAGTAAGGTGAATGCCACCTTCAGCGAAGCCTC           GCCAGTGGAGCTGAAGTTGACAGGCATTTACAAGAAGGAGGAGGCCCACTTACTCCTGAAAGCTTTTC           AAATTAAAGGCCAGGCAGATATTTTTGTAAGCAAGTTCGAAAATGACAACTGGGGACTAGATGGTTAT           ATTTAAGCTAGAAAGGCAAGATCCTTTAAACCCAGATCAAGACTCTTCCAGTCATTACCACGGCACCA           GCAGTGGCTCTGTGGCGGCTGCCATTCTGGTTCCTTTCTTTGCTCTAATTTTATCAGGGTTTGCATTT           TACCTCTACAAACACAGAACGAGACCAAAAGTTCAATACAATGGCTATGCTGGGCATGAAAACAGCAA           TGGACAAGCATCGTTTGAAAACCCCATGTATGATACAAACTTAAAACCCACAGAAGCCAAGGCTGTGA           GGTTTGACACAAGTGTGAACACAGTCTGTACAGTGGTA TGA                                               NOV54b, CG59905-03   SEQ ID NO:1112   3567 aa   MW at 389007.4 kD           Protein Sequence                             MTAWRRFQSLLLLLGLLVLCARLLTAAKGQNCGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERN               RIQLSFHTFALEENFDILSVYDGQPQQGNLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKAL           YEVLPSHTCGNPGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRA           EGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYDFLEISGTEAPSI           WLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELKSRGVKMLPSKDGSHKNSVLSQG           GVALVSHMCLDPGIPENGRPAGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICR           ARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVG           DTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGSSF           LHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCV           TTGRGFNITYTTFGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVW           SSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKMTFDRFQTEVNYDTLEVR           DGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCLDPGIPVNGH           RHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALCGGYIQGKSGTVLSPGFPDFYP           NSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQ           LRFISDFSISYEGFNITFSEYDLEPCDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLG           TLKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLVKCEDPGIP           NYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIAECGGQIHAATSGRILS           PGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDIHS           TFNSLTLQFDSDFFISKSGFSIQFSTSIAATCNDPGMPQNGTRYGDSREAGDTVTFQCDPGYQLQGQA           KITCVQLNNRFFWQPDPPTCIAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKS           FNMEPSYDFLHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREA           CFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCNAPCGGQYTG           SEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDGTHAQARLLSSLSGSHS           GETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRTSDTQCSSVPEPRYGRRIGSEFSAGSIVRFEC           NPGYLLQGSTALHCQSVPNALAQWNDTIPSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVT           EGSGIQDPSDQFCHGAELGLPFEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAG           FHLEYKTVGLAACQEPALPSNSIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLC           IATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDFLEIQNGPYHTS           PMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNCPDPPPFQNGYMINSDYSVG           QSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIW           LITVPPGHGVYINFTLLQTEAVNDYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSN           GGFFVLNFHAFQLKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEG           SLPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDALEVF           DGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPYCSLTHPLKNGGILNR           TAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTGNEFTLD           SKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPMCKPVACPSIEAQLSEHVIWRLVSGSLNEYGA           QVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTLTVYGATAIFTCNT           GYTLVGSHVRECLANGLWSGSETRCLAGHCGSPDPIVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVR           ICLQDHKWSGQTPVCVRITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSS           PLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKC           LAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGD           PGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIV           SSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTVISCGDPGTLANGIQFGTDFTFNKT           VSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDG           YQLSHSAILSCEGRGVWKGEIPQCLAVFCGDPGIPAEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRV           CQADGTWSGIQPTCIGDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANL           TWSGIQTECIRHACRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPV                       CKSKGVREVNETVTKTPVPSDVFFVNSLWKGYYEYLGKRQPATLTVDWFNATSSKVNATFSEASPVEL           KLTGTYKKEEAHLLLKAFQIKGQADIFVSKFENDNWGLDGYVSSGLERGGFTFQGDIHGKDFGKFKLE           RQDPLNPDQDSSSHYHGTSSGSVAAAILVPFFALILSGFAFYLYKHRTRPKVQYNGYAGHENSNGQAS           FENPMYDTNLKPTEAKAVRFDTTLNTVCTVV                                         NOV54c, 275631102   SEQ ID NO:1113   898 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                               C ACCAGATCTTGTGGACACCCAGGGGTCCCTGCCAACGCCGTCCTCACTGGAGAGCTGTTTACCTATG               GCGCCGTCGTGCACTACTCCTGCAGAGGGAGCGAGAGCCTCATAGGCAACGACACGAGAGTGTGCCAG           GAAGACAGTCACTGGAGCGGGGCACTGCCCCACTGCACAGGAAATAATCCTGGATTCTGTGGTGATCC           GGGGACCCCAGCACATGGGTCTCGGCTTGGTGATGACTTTAAGACAAAGAGTCTTCTCCGCTTCTCCT           GTGAAATGGGGCACCAGCTGAGGGGCTCCCCTGAACGCACGTGTTTGCTCAATGGGTCATGGTCAGGA           CTGCAGCCGGTGTGTGAGGCCGTGTCCTGTGGCAACCCTGGCACACCCACCAACGGAATGATTGTCAG           TAGTGATGGCATTCTGTTCTCCAGCTCGGTCATCTATGCCTGCTGGGAAGGCTACAAGACCTCAGGGC           TCATGACACGGCATTGCACAGCCAATGGGACCTGGACAGGCACTGCTCCCGACTGCACAATTATAAGT           TGTGGGGATCCAGGCACACTAGCAAATGGCATCCAGTTTGGGACCGACTTCACCTTCAACAAGACTGT           GAGCTATCAGTGTAACCCAGGCTATGTCATGGAAGCAGTCACATCCGCCACTATTCGCTGTACCAAAG           ACGGCAGGTGGAATCCGAGCAAACCTGTCTGCAAAGCCGTGCTGTGTCCTCAGCCGCCGCCGGTGCAG           AATGGAACAGTGGAGGGAAGTGATTTCCGCTGGGGCTCCAGCATAAGTTACAGCTGCATGGACGGTTA           CCAGCTCTCTCACTCCGCCATCCTCTCCTGTGAAGGTCGCGGGGTGTGGAAAGGAGAGATCCCCAGTG           TCTGCCTCGAGGGC                                             NOV54c, 275631102   SEQ ID NO:1114   299 aa   MW at 31648.2 kD           Protein Sequence                             TRSCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDP               GTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVS           SDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANGIQFGTDFTFNKTV           SYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGY           QLSHSAILSCEGRGVWKGEIPSVCLEG                                         NOV54d, CG59905-02   SEQ ID NO:1115   3019 bp           DNA Sequence   ORF Start: ATG at 184   ORF Stop: TAA at 2614                               CTGCCAGGCTGTGTCCTGTGGAATCCCAGAATCCCCAGGAAACGGTTCATTACCGGGAACGAGTTCAC                   TTTGGACAGTAAAGTGGTCTATGAATGTCATGAGGGCTTCAAGCTTGAATCCAGCCAGCAAGCAACAG               CCGTGTGTCAAGAAGATGGGCTGTGGAGTAACAAGGGGAAGCCGCCC   ATG TGTAAGCCGGTCGCTTGC           CCCAGCATTGAAGCTCAGCTCTCAGAACATGTCATCTGGAGGCTGGTTTCAGGATCCTTGAATGAGTA           CGGTGCTCAAGTATTGCTGAGCTGCAGTCCTGGTTACTACTTAGAAGGCTGGAGGCTCCTGCGGTGCC           AGGCCAATGGGACGTGGAGCATAGGAGATGAGAGGCCAAGCTGTCGAGTTATCTCGTGTGGAAGCCTT           TCCTTTCCCCCAAATGGCAACAAGATTGGAACGTTGACAGTTTATGGGGCCACAGCTATATTTACGTG           CAACACCGGCTACACGCTTGTGGGGTCTCATGTCAGAGAGTGCTTGGCAAATGGGCTCTGGAGCGGCA           GCGAAACTCGATGTCTGGCTGGCCACTGCGGTTCCCCAGACCCGATTGTGAACGGTCACATTAGTGGA           GATGGCTTCAGTTACAGAGACACGGTGGTTTACCAGTGCAATCCTGGTTTCCGGCTTGTGGGAACTTC           CGTGAGGATATGCCTGCAAGACCACAAGTGGTCTGGACAAACGCCTGTCTGTGTCGCCATCACATGTG           GTCACCCTGGAAACCCTGCCCACGGATTCACTAATGGCAGTGAGTTCAACCTGAATGATGTCGTGAAT           TTCACCTGCAACACGGGCTATTTGCTGCAGGGCGTGTCTCGAGCCCAGTGTCGGAGCAACGGCCAGTG           GAGTAGCCCTCTGCCCACGTCTCGACACGTGGGCAGAGGGCTACTCCACTGGCGGTTGCTCCGACACG           GGGCTCCGAGACACGCCCTGCAGCAAATAGCCCGTGTTGCAGGTGAAATTCACGACATCATTATTTTA           CTTGCTGGATCTTCAGCCTTGACCTGTATGGCAAATGGCTTATGGGACCGATCCCTGCCCAAGTGTTT           GGCTATATCGTGTGGACACCCAGGGGTCCCTGCCAACGCCGTCCTCACTGGAGAGCTGTTTACCTATG           GCGCCGTCGTGCACTACTCCTGCAGAGGGAGCGAGAGCCTCATAGGCAACGACACGAGAGTGTGCCAG           GAAGACAGTCACTGGAGCGGGGCACTGCCCCACTGCACAGGTAATAATCCTGGATTCTGTGGTGATCC           GGGGACCCCAGCACATGGGTCTCGGCTTGGTGATGACTTTAAGACAAAGAGTCTTCTCCGCTTCTCCT           GTGAAATGGGGCACCAGCTGAGGGGCTCCCCTGAACGCACGTGTTTGCTCAATGGGTCATGGTCAGGA           CTGCAGTCGGTGTGTGAGGCCGTGTCCTGTGGCAACCCTGGCACACCCACCAACGGAATGATTGTCAG           TAGTGATGGCATTCTGTTCTCCAGCTCGGTCATCTATGCCTGCTGGGAAGGCTACAAGACCTCAGGGC           TCATGACACGGCATTGCACAGCCAATGGGACCTGGACAGGCACTGCTCCCGACTGCTTAGTTATAAGT           TGTGGGGATCCAGGCACACTAGCAAATGGCATCCAGTTTGGGACCGACTTCACCTTCAACAAGACTGT           GAGCTATCAGTGTAACCCAGGCTATGTCATGGAAGCAGTCACATCCGCCACTATTCGCTGTACCAAAG           ACGGCAGGTGGAATCCGAGCAAACCTGTCTGCAAAGGTTTGCTGTGTCCTCAGCCGCCGCCGGTGCAG           AATGGAACAGTGGAGGGAAGTGATTTCCGCTGGGGCTCCAGCATAAGTTACAGCTGCATGGACGGTTA           CCAGCTCTCTCACTCCGCCATCCTCTCCTGTGAAGGTCGCGGGGTGTGGAAAGGAGAGATCCCCCAGT           GTCTGCCTGTGTTCTGCGGAGACCCTGGCATCCCCGCAGAGGGGCGACTTAGTGGGAAAAGTTTCACC           TATAAGTCCGAAGTCTTCTTCCAGTGCAAATCTCCATTTATACTCGTGGGATCCTCCAGAAGAGTCTG           CCAAGCTGACGGCACGTGGAGCGGCATACAACCCACCTGCATTGATCCTGCTCATAACACCTGCCCAG           ACCCTGGTACGCCACACTTTGGAATACAGAATAGCTCCAGAGGCTATGAGGTTGGAAGCACGGTTTTT           TTCAGGTGCAGAAAAGGCTACCATATTCAAGGTTCCACGACTCGCACCTGCCTTGCCAATTTAACATG           GAGTGGGATACAGACCGAATGTATACCTCATGCCTGCAGACAGCCAGAAACCCCGGCACACGCGGATG           TGAGAGCCATCGATCTTCCTACTTTCGGCTACACCTTAGTGTACACCTGCCATCCAGGCTTTTTCCTC           GCAGGGGGATCTGAGCACAGAACATGTAAAGCAGACATGAAATGGACAGGAAAGTCGCCTGTGTGTAA           AAGTAAGTCATTGATCAAGGAGTGGCATACTTTTCCAAAGAGCAAGGGAAAGGATCAGCTGCCCATCA           GGCTAGTGTCCACGTGTGAGACCCATAAG TAA   GAGCATGAGGCTGCAGCATCGCCACCTGCCTCAGTC               GTGCTTCATGTGCGTGAGCTGTGTGTGTGAACGTGTGTATCCTCAGTGTTTGATGCAATGGTGGCATA               GCTAAATATATAGTACAATTAGTATGCAATTAGTACATAATAAAATGATTGCATTATTTCAAGCCAAA               AGAGAAAAGCTATTTGGTTAAAGAAAAGCATTCTGAGTTAAAAGGAAAATAATACTTGGTATAGTTTC               AGGAAAAGTAGTTCTTAGAGATGAAAATGAATAAAGGTCACCAAGTATCCGAGAATAGGTAAATGAAA               CTCTGTCTTATTTTTAAGACCACATGCTGTTTGTGGTAAAACCTCAGTTTATGTGTCCCTGACATTGA               TTCTGCTTTTTAAAATTACAAAAGCAA                                               NOV54d, CG59905-02   SEQ ID NO:1116   810 aa   MW at 87208.0 kD           Protein Sequence                             MCKPVACPSIEAQLSEHVTWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWSIGDERPSCR               VISCGSLSFPPNGNKIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSPDPI           VNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVAITCGHPGNPAHGFTNGSEF           NLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTSRHVGRGLLHWRLLRHGAPRRALQQIARVAGE           IHDIIILLAGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIG           NDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCL           LNGSWSGLQSVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTA           PDCLVISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKGLLC           PQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGR           LSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRGY           EVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYT           CHPGFFLAGGSEHRTCKADMKWTGKSPVCKSKSLIKEWHTFPKSKGKDQLPIRLVSTCETHK                                         NOV54e, SNP13382527 of   SEQ ID NO:1117   3145 bp           CG59905-01, DNA Sequence   ORF Start: ATG at 34   ORF Stop: TGA at 3046           SNP Pos: 392   SNP Change: T to C                               ATTTTACTTGCTGGATCTTCAGCCTTGACCTGT   ATG GCAAATGGCTTATGGGACCGATCCCTGCCCAA               GTGTTTGGCTATATCCTGTGGACACCCAGGGGTCCCTGCCAACGCCGTCCTCACTGGAGAGCTGTTTA           CCTATGGCGCCGTCGTGCACTACTCCTGCAGAGGGAGCGAGAGCCTCATAGGCAACGACACGAGAGTG           TGCCAGGAAGACAGTCACTGGAGCGGGGCACTGCCCCACTGCACAGGAAATAATCCTGGATTCTGTGG           TGATCCGGGGACCCCAGCACATGGGTCTCGGCTTGGTGATGACTTTAAGACAAAGAGTCTTCTCCGCT           TCTCCTGTGAAATGGGGCACCAGCTGAGGGGCTCCCCTGAACGCACGTGTT   C   GCTCAATGGGTCATGG           TCAGGACTGCAGCCGGTGTGTGAGGCCGTGTCCTGTGGCAACCCTGGCACACCCACCAACGGAATGAT           TGTCAGTAGTGATGGCATTCTGTTCTCCAGCTCGGTCATCTATGCCTGCTGGGAAGGCTACAAGACCT           CAGGGCTCATGACACGGCATTGCACAGCCAATGGGACCTGGACAGGCACTGCTCCCGACTGCACAATT           ATAAGTTGTGGGGATCCAGGCACACTAGCAAATGGCATCCAGTTTGGGACCGACTTCACCTTCAACAA           GACTGTGAGCTATCAGTGTAACCCAGGCTATGTCATGGAAGCAGTCACATCCGCCACTATTCGCTGTA           CCAAAGACGGCAGGTGGAATCCGAGCAAACCTGTCTGCAAAGCCGTGCTGTGTCCTCAGCCGCCGCCG           GTGCAGAATGGAACAGTGGAGGGAAGTGATTTCCGCTGGGGCTCCAGCATAAGTTACAGCTGCATGGA           CGGTTACCAGCTCTCTCACTCCGCCATCCTCTCCTGTGAAGGTCGCGGGGTGTGGAAAGGAGAGATCC           CCAGTGTCTGCCTGTGTTCTGCGGAGACCCTGGCATCCCCGCAGAAGGGCGACTTAGTGGGAAAAGTT           TCACCTATAAGTCCGAAGTCTTCTTCCAGTGCAAATCTCCATTTATACTCGTGGGATCCTCCAGAAGA           GTCTGCCAAGCTGACGGCACGTGGAGCGGCATACAACCCACCTGCATTGGTAATAATTATCATACAGC           TCTGGGGATACCTGGGAGTATTTGGAGATGAGGACGCTTCATTCCGAAATTGGGTCATTTGTGATTAC           ATAGAAAGTGTTTCCATAGACAGTTTTCTGTACAAGGTTGGAAGCACGGTTTTTTTCAGGTGCAGAAA           AGGCTACCATATTCAAGGTTCCACGACTCGCACCTGCCTTGCCAATTTAACATGGAGTGGGATACAGA           CCGAATGTATACCTCATGCCTGCAGACAGCCAGAAACCCCGGCACACGCGGATGTGAGAGCCATCGAT           CTTCCTACTTTCGGCTACACCTTAGTGTACACCTGCCATCCAGGCTTTTTCCTCGCAGGGGGATCTGA           GCACAGAACATGTAAAGCAGACATGAAATGGACAGGAAAGTCGCCTGTGTGTAAAATTCCTTCAGATG           TCTTTTTCGTCAATTCACTGTGGAAGGGGTATTATGAATATTTAGGGAAAAGACAACCCGCCACTCTA           ACTGTTGACTGGTTCAATGCAACAAGCAGTAAGGTGAATGCCACCTTCAGCGAAGCCTCGCCAGTGGA           GCTGAAGTTGACAGGCATTTACAAGAAGGAGGAGGCCCACTTACTCCTGAAAGCTTTTCAAATTAAAG           GCCAGGCAGATATTTTTGTAAGCAAGTTCGAAAATGACAACTGGGGACTAGATGGTTATGTGTCATCT           GGACTTGAAAGAGGAGGATTTACTTTTCAAGGTGACATTCATGGAAAAGACTTTGGAAAATTTAAGCT           AGAAAGGCAAGGATGGGTCACAATATTCTTGAGCCTATTTCTTCATCTTAAATCTCAGTATAGAAGTT           CCCAAGGTTGTTACGAGATTGAGAGGCCACATCCTTTAAACCCAGATCAAGACTCTTCCAGTCATTAC           CACGGCACCAGCAGTGGCTCTGTGGCGGCTGCCATTCTGGTTCCTTTCTTTGCTCTAATTTTATCAGG           GTTTGCATTTTACCTCTACAAACACAGAACGAGACCAAAAGTTCAATACAATGGCTATGCTGGGCATG           AAAACAGCAATGGACAAGCATCGTTTGAAAACCCCATGTATGATACAAACTTAAAACCCACAGAAGCC           AAGGCTAAAACCACACACGGGCTGCTCACGTCTCTGGACTCCAAGAGAAAGATGGTTATAACCCTGGC           AGAGTCTTTACCCGCCCTGCGAACCTGCCTGTTGATCTGCTTCCCACTCCTCTTTAGACTTGCTCGTG           AATCTTCAGCACAGCCATTTGTTTTGAGTATTCAAACACATAAAAAGATATCTGGCAACTTCCCACTT           CTTATGACTTCTCAGACACCTTGTAACGGAGCTTCCCTTGGAGGTGGACAAACTTCTCACTCACAAGA           GAGACGGAGAGCAACAGAGAGAGATGGGCAGGGATTGATTCGAGGATTGGCTGACTCGATTATGGAGG           GTGAGAAGTCCCAGGACAGGCCGTCTGCAAGGCGTAAACCCAGGGAAGCTGCTGGTATGGCTCGGTTC           AAGTCCAAAGGCCTCAGCACCAAGGAAACCAAGGTGATAACTCTCAGTTCGGGTCAAAGTCCTGGGAG           TCTGCAAGGCCTCTCATTGAGTAAGTCTCACAAGATCCGATGGTTTTATAAAGGGCAGTTCCCCTGCA           CAAGCTCTCTTCTCTGCCACCACGCGTTTGCTGTTCATTCACCTTTCACCATGATTGTGAGGCCTCCC           AGCCATGTGGAACTGTGCAAAGAGGATGTTCAAAGGGCATCTTGGACCAGGAGGAGGAAGCCCATTGT           GAGGATGGCAAAGAACAATAAATGGAAGGCCCGTGGAACCCTGAGCGGCTGCCCCATCACTGTCCTCT           CCATCCTTTCCATGCTTCCCATGGTGCATGGCTCTCAGGCTCTCCAAGCACCA TGA   GCTCCTGGCGCG               TATGGCCTGGCCCCTGAGTGTGGAGTCTGTGGACTTTAAATGTGCCTTTACTCAGCCAGCATCTCCCT               GGCTGGGTGCGATGTTG                                               NOV54e, SNP13382527 of   SEQ ID NO:1118   1004 aa   MW at 109726.6 kD           CG59905-01, Protein   SNP Pos: 120       SNP Change: Leu to Ser       Sequence                             MANGLWDRSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGAL               PHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCSLNGSWSGLQPVCEAVS           CGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLAN           GIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDF           RWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPSVCLCSAETLASPQKGDLVGKVSPISPKSSSSA           NLHLYSWDPPEESAKLTARGAAYNPPALVTIIIQLWGYLGVFGDEDASFRNWVICDYIESVSIDSFLY           KVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYT           CHPGFFLAGGSEHRTCKADMKWTGKSPVCKIPSDVFFVNSLWKGYYEYLGKRQPATLTVDWFNATSSK           VNATFSEASPVELKLTGIYKKEEAHLLLKAFQIKGQADIFVSKFENDNWGLDGYVSSGLERGGFTFQG           DIHGKDFGKFKLERQGWVTIFLSLFLHLKSQYRSSQGCYEIERPHPLNPDQDSSSHYHGTSSGSVAAA           ILVPFFALILSGFAFYLYKHRTRPKVQYNGYAGHENSNGQASFENPMYDTNLKPTEAKAKTTHGLLTS           LDSKRKMVITLAESLPALRTCLLICFPLLFRLARESSAQPFVLSIQTHKKISGNFPLLMTSQTPCNGA           SLGGGQTSHSQERRRATERDGQGLIRGLADSIMEGEKSQDRPSARRKPREAAGMARFKSKGLSTKETK           VITLSSGQSPGSLQGLSLSKSHKIRWFYKGQFPCTSSLLCHHAFAVHSPFTMIVRPPSHVELCKEDVQ           RASWTRRRKPIVRMAKNNKWKARGTLSGCPITVLSILSMLPMVHGSQALQAP                                         NOV54f, SNP13382520 of   SEQ ID NO:1119   3145 bp           CG59905-01, DNA Sequence   ORF Start: ATG at 34   ORF Stop: TGA at 3046           SNP Pos: 1620   SNP Change: A to T                               ATTTTACTTGCTGGATCTTCAGCCTTGACCTGT   ATG GCAAATGGCTTATGGGACCGATCCCTGCCCAA               GTGTTTGGCTATATCCTGTGGACACCCAGGGGTCCCTGCCAACGCCGTCCTCACTGGAGAGCTGTTTA           CCTATGGCGCCGTCGTGCACTACTCCTGCAGAGGGAGCGAGAGCCTCATAGGCAACGACACGAGAGTG           TGCCAGGAAGACAGTCACTGGAGCGGGGCACTGCCCCACTGCACAGGAAATAATCCTGGATTCTGTGG           TGCTCCGGGGACCCCAGCACATGGGTCTCGGCTTGGTGATGACTTTAAGACAAAGAGTCTTCTCCGCT           TCTCCTGTGAAATGGGGCACCAGCTGAGGGGCTCCCCTGAACGCACGTGTTTGCTCAATGGGTCATGG           TCAGGACTGCAGCCGGTGTGTGAGGCCGTGTCCTGTGGCAACCCTGGCACACCCACCAACGGAATGAT           TGTCAGTAGTGATGGCATTCTGTTCTCCAGCTCGGTCATCTATGCCTGCTGGGAAGGCTACAAGACCT           CAGGGCTCATGACACGGCATTGCACAGCCAATGGGACCTGGACAGGCACTGCTCCCGACTGCACAATT           ATAAGTTGTGGGGATCCAGGCACACTAGCAAATGGCATCCAGTTTGGGACCGACTTCACCTTCAACAA           GACTGTGAGCTATCAGTGTAACCCAGGCTATGTCATGGAAGCAGTCACATCCGCCACTATTCGCTGTA           CCAAAGACGGCAGGTGGAATCCGAGCAAACCTGTCTGCAAAGCCGTGCTGTGTCCTCAGCCGCCGCCG           GTGCAGAATGGAACAGTGGAGGGAAGTGATTTCCGCTGGGGCTCCAGCATAAGTTACAGCTGCATGGA           CGGTTACCAGCTCTCTCACTCCGCCATCCTCTCCTGTGAAGGTCGCGGGGTGTGGAAAGGAGAGATCC           CCAGTGTCTGCCTGTGTTCTGCGGAGACCCTGGCATCCCCGCAGAAGGGCGACTTAGTGGGAAAAGTT           TCACCTATAAGTCCGAAGTCTTCTTCCAGTGCAAATCTCCATTTATACTCGTGGGATCCTCCAGAAGA           GTCTGCCAAGCTGACGGCACGTGGAGCGGCATACAACCCACCTGCATTGGTAATAATTATCATACAGC           TCTGGGGATACCTGGGAGTATTTGGAGATGAGGACGCTTCATTCCGAAATTGGGTCATTTGTGATTAC           ATAGAAAGTGTTTCCATAGACAGTTTTCTGTACAAGGTTGGAAGCACGGTTTTTTTCAGGTGCAGAAA           AGGCTACCATATTCAAGGTTCCACGACTCGCACCTGCCTTGCCAATTTAACATGGAGTGGGATACAGA           CCGAATGTATACCTCATGCCTGCAGACAGCCAGAAACCCCGGCACACGCGGATGTGAGAGCCATCGAT           CTTCCTACTTTCGGCTACACCTTAGTGTACACCTGCCATCCAGGCTTTTTCCTCGCAGGGGGATCTGA           GCACAGAACATGTAAAGCAGACATGAAATGGACAGGAAAGTCGCCTGTGTGTAAAATTCCTTCAGATG           TCTTTTTCGTCAATTCACTGTGGAAGGGGTATTATGAATATTTAGGGAAAAGACATCCCGCCACTCTA           ACTGTTGACTGGTTCAATGCAACAAGCAGTAAGGTGAATGCCACCTTCAGCGAAGCCTCGCCAGTGGA           GCTGAAGTTGACAGGCATTTACAAGAAGGAGGAGGCCCACTTACTCCTGAAAGCTTTTCAAATTAAAG           GCCAGGCAGATATTTTTGTAAGCAAGTTCGAAAATGACAACTGGGGACTAGATGGTTATGTGTCATCT           GGACTTGAAAGAGGAGGATTTACTTTTCAAGGTGACATTCATGGAAAAGACTTTGGAAAATTTAAGCT           AGAAAGGCAAGGATGGGTCACAATATTCTTGAGCCTATTTCTTCATCTTAAATCTCAGTATAGAAGTT           CCCAAGGTTGTTACGAGATTGAGAGGCCACATCCTTTAAACCCAGATCAAGACTCTTCCAGTCATTAC           GTTTGCATTTTACCTCTACAAACACAGAACGAGACCAAAAGTTCAATACAATGGCTATGCTGGGCATG           AAAACAGCAATGGACAAGCATCGTTTGAAAACCCCATGTATGATACAAACTTAAAACCCACAGAAGCC           AAGGCTAAAACCACACACGGGCTGCTCACGTCTCTGGACTCCAAGAGAAAGATGGTTATAACCCTGGC           AGAGTCTTTACCCGCCCTGCGAACCTGCCTGTTGATCTGCTTCCCACTCCTCTTTAGACTTGCTCGTG           AATCTTCAGCACAGCCATTTGTTTTGAGTATTCAAACACATAAAAAGATATCTGGCAACTTCCCACTT           CTTATGACTTCTCAGACACCTTGTAACGGAGCTTCCCTTGGAGGTGGACAAACTTCTCACTCACAAGA           GAGACGGAGAGCAACAGAGAGAGATGGGCAGGGATTGATTCGAGGATTGGCTGACTCGATTATGGAGG           GTGAGAAGTCCCAGGACAGGCCGTCTGCAAGGCGTAAACCCAGGGAAGCTGCTGGTATGGCTCGGTTC           AAGTCCAAAGGCCTCAGCACCAAGGAAACCAAGGTGATAACTCTCAGTTCGGGTCAAAGTCCTGGGAG           TCTGCAAGGCCTCTCATTGAGTAAGTCTCACAAGATCCGATGGTTTTATAAAGGGCAGTTCCCCTGCA           CAAGCTCTCTTCTCTGCCACCACGCGTTTGCTGTTCATTCACCTTTCACCATGATTGTGAGGCCTCCC           AGCCATGTGGAACTGTGCAAAGAGGATGTTCAAAGGGCATCTTGGACCAGGAGGAGGAAGCCCATTGT           GAGGATGGCAAAGAACAATAAATGGAAGGCCCGTGGAACCCTGAGCGGCTGCCCCATCACTGTCCTCT           CCATCCTTTCCATGCTTCCCATGGTGCATGGCTCTCAGGCTCTCCAAGCACCA TGA   GCTCCTGGCGCG               TATGGCCTGGCCCCTGAGTGTGGAGTCTGTGGACTTTAAATGTGCCTTTACTCAGCCAGCATCTCCCT               GGCTGGGTGCGATGTTG                                               NOV54f, SNP13382520 of   SEQ ID NO:1120   1004 aa   MW at 109761.8 kD           CG59905-01, Protein Sequence   SNP Pos: 529       SNP Change: Gln to His                             MANGLWDRSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGAL               PHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVS           CGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLAN           GIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDF           RWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPSVCLCSAETLASPQKGDLVGKVSPISPKSSSSA           NLHLYSWDPPEESAKLTARGAAYNPPALVIIIIQLWGYLGVFGDEDASFRNWVICDYIESVSIDSFLY           KVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYT           CHPGFFLAGGSEHRTCKADMKWTGKSPVCKIPSDVFFVNSLWKGYYEYLGKR   H   PATLTVDWFNATSSK           VNATFSEASPVELKLTGIYKKEEAHLLLKAFQIKGQADIFVSKFENDNWGLDGYVSSGLERGGFTFQG           DIHGKDFGKFKLERQGWVTIFLSLFLHLKSQYRSSQGCYEIERPHPLNPDQDSSSHYHGTSSGSVAAA           ILVPFFALILSGFAFYLYKHRTRPKVQYNGYAGHENSNGQASFENPMYDTNLKPTEAKAKTTHGLLTS           LDSKRKMVITLAESLPALRTCLLICFPLLFRLARESSAQPFVLSIQTHKKISGNFPLLMTSQTPCNGA           SLGGGQTSHSQERRRATERDGQGLIRGLADSIMEGEKSQDRPSARRKPREAAGMARFKSKGLSTKETK           VITLSSGQSPGSLQGLSLSKSHKIRWFYKGQFPCTSSLLCHHAFAVHSPFTMIVRPPSNVELCKEDVQ           RASWTRRRKPIVRMAKNNKWKARGTLSGCPITVLSILSMLPMVHGSQALQAP                      
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 54B.  
               TABLE 54B                       Comparison of the NOV54 protein sequences.                                        NOV54a ------------------------------------------------------------           NOV54b MTAWRRFQSLLLLLGLLVLCARLLTAAKGQNCGGLVQGPNGTIESPGFPHGYPNYANCTW       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b IIITGERNRIQLSFHTFALEENFDILSVYDGQPQQGNLKVRLSGFQLPSSIVSTGSILTL       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b WFTTDFAVSAQGFKALYEVLPSHTCGNPGEILKGVLHGTRFNIGDKIRYSCLPGYILEGH       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b AILTCIVSPGNGASWDFPAPFCHAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILA       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b EPGDTIALVFTDFQLEEGYDFLEISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNH       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b RRKGFNAQFQVKKAIELKSRGVKMLPSKDGSHKNSVLSQGGVALVSHMCLDPGIPENGRR       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b AGSDFSRVGANVQFSCEDNYVLQGSKSTTCQRVTETLAAWSDHRPICRARTCGSNLRGPS       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b GVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRS       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b VLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRT       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b GSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFSCFFNFTASSGIILSPN       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b YPEEYGNNMNCVWLTISEPGSRIHLIFNDFDVEPQFDFLAVKDNGISDITVLGTFSGNEV       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b PSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPGIPINGRRFGDRFLLGSSV       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b SFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYK       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b DSLHCEWIIEAKPGHSIKMTFDRFQTEVNYDTLEVRDGPASSSPLIGEYHGTQAPQFLIS       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b TGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCLDPGIPVNGHRHGGDFGIRSTVTFSC       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b DPGYTLSDDEPLVCERNHQWNHALPSCDALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWT       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b IEVSHGKGVQMIFHTFHLESSHDYLLITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQ       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b LRFISDFSISYEGFNITFSEYDLEPCDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEG       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b ATKLTCLGGGRRVWSAPLPRCVAECGASVKGNEGTLLSPNFPSNYDNTHECIYKIETEAG       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b KGIHLRTRSFQLFEGDTLKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGS       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b DTDQGFQLTYTSFDLVKCEDPGIPNYGYRIRDEGHFTDTVVLYSCNPGYANHGSNTLTCL       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b SGDPRVWDKPLPSCIAECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLH       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b FIVFDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGF       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b SIQFSTSIAATCNDPGMPQNGTRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFF       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b WQPDPPTCIAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNME       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b PSYDFLHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEK       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b PREACFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLP       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b SCNAPCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAE       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b LFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRTSDT       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b QCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCV       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b VPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQDPSDQFCHGAELGLPFEI       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b HDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQEP       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b ALPSNSIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIATCGGTL       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b STLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDFLEIQNGPYHTS       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b PMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNCPDPPPFQNGYM       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b INSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCGYNVTSQNGTIY       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b SPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVNDYIAVWDGPDQNSPQLGVFSG       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b NTALETAYSSTNQVLLKFHSDFSNGGFFVLNFHAFQLKKCQPPPAVPQAEMLTEDDDFEI       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b GDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEAQCPANEVRTGSSGVILSPGYP       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b GNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQ       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b SNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPYCSLTHPLKNGGILNRTAGAVGSKVHYF       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b CKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTGNEFTLDSKVV       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ------------------------------------------------------------       NOV54b YECHEGFKLESSQQATAVCQEDGLWSNKGKPPMCKPVACPSIEAQLSEHVIWRLVSGSLN       NOV54c ------------------------------------------------------------       NOV54d --------------------------------MCKPVACPSIEAQLSENVIWRLVSGSLN               NOV54a ------------------------------------------------------------       NOV54b EYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTLT       NOV54c ------------------------------------------------------------       NOV54d EYGAQVLLSCSPGYYLEGWRLLRCQANGTWSIGDERPSCRVISCGSLSFPPNGNKIGTLT               NOV54a ------------------------------------------------------------       NOV54b VYGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSPDPIVNGHISGDGFSY       NOV54c ------------------------------------------------------------       NOV54d VYGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSPDPIVNGHISGDGFSY               NOV54a ------------------------------------------------------------       NOV54b RDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVRITCGHPGNPAHGFTNGSEFNLND       NOV54c ------------------------------------------------------------       NOV54d RDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVAITCGHPGNPAHGFTNGSEFNLND               NOV54a ------------------------------------------------------------       NOV54b VVNFTCNTGYLLQGVSPAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFE       NOV54c ------------------------------------------------------------       NOV54d VVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTSRHVGRG--LLHWRLLRHG-APRHALQQ               NOV54a -----------------------MANGLWDRSLPKCLATSCGHPGVPANAVLTGELFTYG       NOV54b YGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLTGELFTYG       NOV54c -------------------------------------TRSCGHPGVPANAVLTGELFTYG       NOV54d IARVAGEIHDIIILLAGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLTGELFTYG               NOV54a AVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKT       NOV54b AVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKT       NOV54c AVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKT       NOV54d AVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKT               NOV54a KSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFS       NOV54b KSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFS       NOV54c KSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFS       NOV54d KSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQSVCEAVSCGNPGTPTNGMIVSSDGILFS               NOV54a SSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANGIQFGTDFTFNKT       NOV54b SSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTVISCGDPGTLANGIQFGTDFTFNKT       NOV54c SSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANGIQFGTDFTFNKT       NOV54d SSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCLVISCGDPGTLANGIQFGTDFTFNKT               NOV54a VSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDFRWGSS       NOV54b VSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDFRWGSS       NOV54c VSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDFRWGSS       NOV54d VSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKGLLCPQPPPVQNGTVEGSDFRWGSS               NOV54a ISYSCMDGYQLSHSAILSCEGRGVWKGEIPSVCLCSAETIASPQKGDLVGKVSPISPKSS       NOV54b ISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLAVFCGDPGIPAEGRLSGKSFTYKSEVF       NOV54c ISYSCMDGYQLSHSAILSCEGRGVWKGEIPSVCLEG------------------------       NOV54d ISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLSGKSFTYKSEVF               NOV54a SSANLHLYSWDPPEESAKLTARGAAYNPPALVIIIIQLWGYLGVFGDEDASFRNWVICDY       NOV54b FQCKSPFILVGSSRRVCQADGTWSGIQPTCIGDPAHNTCPDPGTPHFG------------       NOV54c ------------------------------------------------------------       NOV54d FQCKSPFILVGSSRRVCQADGTWSGIQPTCI-DPAHNTCPDPGTPHFG------------               NOV54a IESVSIDSFLYKVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPA       IWV54b ---IQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIRHACRQPETPA       NOV54c ------------------------------------------------------------       NOV54d ---IQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPA               NOV54a HADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKIP---------       NOV54b HADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKSKGVREVNETV       NOV54c ------------------------------------------------------------       NOV54d HADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKSK---------               NOV54a ------SDVFFVNSLWKGYYEYLGKRQPATLTVDWFNATSSKVNATFSEASPVELKLTGI       NOV54b TKTPVPSDVFFVNSLWKGYYEYLGKRQPATLTVDWFNATSSKVNATFSEASPVELKLTGI       NOV54c ------------------------------------------------------------       NOV54d -------------SLIKEWHTFPKSKGKDQLPIRLVSTCETHK-----------------               NOV54a YKKEEAHLLLKAFQIKGQADIFVSKFENDNWGLDGYVSSGLERGGFTFQGDIHGKDFGKF       NOV54b YKKEEAHLLLKAFQIKGQADIFVSKFENDNWGLDGYVSSGLERGGFTFQGDIHGKDFGKF       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a KLERQGWVTIFLSLFLHLKSQYRSSQGCYEIERPHPLNPDQDSSSHYHGTSSGSVAAAIL       NOV54b KLERQ-----------------------------DPLNPDQDSSSHYHGTSSGSVAAAIL       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a VPFFALILSGFAFYLYKHRTRPKVQYNGYAGHENSNGQASFENPMYDTNLKPTEAKAXTT       NOV54b VPFFALILSGFAFYLYKHRTRPKVQYNGYAGHENSNGQASFENPMYDTNLKPTEAKAVRF       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a HGLLTSLDSKRKMVITLAESLPALRTCLLICFPLLFRLARESSAQPFVLSIQTHKKISGN       NOV54b DTTLNTVCTVV-------------------------------------------------       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a FPLLMTSQTPCNGASLGGGQTSHSQERPPATERDGQGLIRGLADSIMEGEKSQDRPSARR       NOV54b ------------------------------------------------------------       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a KPREAAGMARFKSKGLSTKETKVITLSSGQSPGSLQGLSLSKSHKIRWFYKGQFPCTSSL       NOV54b ------------------------------------------------------------       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a LCHHAFAVHSPFTMIVRPPSHVELCKEDVQRASWTRPRKPIVRMAKNNKWKARGTLSGCP       NOV54b ------------------------------------------------------------       NOV54c ------------------------------------------------------------       NOV54d ------------------------------------------------------------               NOV54a ITVLSILSMLPMVHGSQALQAP       NOV54b ----------------------       NOV54c ----------------------       NOV54d ----------------------               NOV54a (SEQ ID NO: 1110)       NOV54b (SEQ ID NO: 1112)       NOV54c (SEQ ID NO: 1114)       NOV54d (SEQ ID NO: 1116)                  
 
      Further analysis of the NOV54a protein yielded the following properties shown in Table 54C.  
               TABLE 54C                       Protein Sequence Properties NOV54a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 8; pos. chg 1; neg. chg 1           H-region:   length 3; peak value 2.05           PSG score:   −2.35                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −6.14           possible cleavage site: between 46 and 47                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 4                                 INTEGRAL   Likelihood =   Transmembrane 367-383               −4.57           INTEGRAL   Likelihood =   Transmembrane 677-693               −7.80           INTEGRAL   Likelihood =   Transmembrane 762-778               −1.91           INTEGRAL   Likelihood =   Transmembrane 979-995               −0.80                             PERIPHERAL   Likelihood = 1.75 (at 148)                         ALOM score: −7.80 (number of TMSs: 4)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 374           Charge difference: −2.0 C(−3.0)-N(−1.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 3a                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:    1   Hyd Moment(75):   14.35           Hyd Moment(95):   11.39   G content:    4           D/E content:    2   S/T content:    3                         Score: −5.37       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 55 CRG|SE                 NUCDISC: discrimination of nuclear localization signals                         pat4: RRKP (4) at 861           pat4: RKPR (4) at 862           pat4: RRRK (5) at 958           pat4: RRKP (4) at 959           pat7: PSARRKP (4) at 858           bipartite: RRKPIVRMAKNNKWKAR at 959           content of basic residues: 10.4%           NLS Score: 1.43       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs:       Ribosomal protein L23 signature (PS00050): *** found ***       RKMVITLAESLPALRT at 753       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 70.6       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         34.8%: nuclear           30.4%: mitochondrial           26.1%: endoplasmic reticulum            4.3%: cytoplasmic            4.3%: peroxisomal                 &gt;&gt; prediction for CG59905-01 is nuc (k = 23)                  
 
      A search of the NOV54a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 54D.  
               TABLE 54D                          Geneseq Results for NOV54a                                         NOV54a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               AAE20901   Human C3b/C4b complement receptor   1 . . . 328   312/328 (95%)   0.0           like protein #2, alternative version -   2378 . . . 2705    313/328 (95%)             Homo sapiens , 3100 aa.           [WO200210199-A2, 07-FEB-2002]       AAE20900   Human C3b/C4b complement receptor   1 . . . 328   312/328 (95%)   0.0           like protein #1 , alternative version -   2347 . . . 2674    313/328 (95%)             Homo sapiens , 3069 aa.           [WO200210199-A2, 07-FEB-2002]       AAE20789   Human C3b/C4b complement receptor   1 . . . 328   312/328 (95%)   0.0           like protein #2 -  Homo sapiens , 3100   2378 . . . 2705    313/328 (95%)           aa. [WO200210199-A2, 07-FEB-2002]       AAE20787   Human C3b/C4b complement receptor   1 . . . 328   312/328 (95%)   0.0           like protein #1 -  Homo sapiens , 3069   2347 . . . 2674    313/328 (95%)           aa. [WO200210199-A2, 07-FEB-2002]       ABU11478   Human MDDT polypeptide SEQ ID 425 -   27 . . . 328    286/302 (94%)   e−176             Homo sapiens , 474 aa.   44 . . . 345    287/302 (94%)           [WO200279449-A2, 10-OCT-2002]                  
 
      In a BLAST search of public sequence databases, the NOV54a protein was found to have homology to the proteins shown in the BLASTP data in Table 54E.  
               TABLE 54E                          Public BLASTP Results for NOV54a                                         NOV54a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               AAK73475   CUB and sushi multiple domains 1   1 . . . 328   312/328 (95%)   0.0           protein -  Homo sapiens  (Human),   2844 . . . 3171    313/328 (95%)           3566 aa.       CAD26764   Sequence 6 from Patent   1 . . . 328   312/328 (95%)   0.0           WO0210199 -  Homo sapiens     2378 . . . 2705    313/328 (95%)           (Human), 3100 aa (fragment).       CAD26763   Sequence 1 from Patent   1 . . . 328   312/328 (95%)   0.0           WO0210199 -  Homo sapiens     2347 . . . 2674    313/328 (95%)           (Human), 3069 aa.       Q96RM4   CUB and sushi multiple domains 1   1 . . . 328   312/328 (95%)   0.0           protein -  Homo sapiens  (Human),   2786 . . . 3113    313/328 (95%)           3508 aa.       Q923L3   CSMD1 -  Mus musculus  (Mouse),   1 . . . 328   279/328 (85%)   e−175           3564 aa.   2842 . . . 3169    297/328 (90%)                  
 
      PFam analysis predicts that the NOV54a protein contains the domains shown in the Table 54F.  
               TABLE 54F                          Domain Analysis of NOV54a                                     Identities/                   Similarities       Pfam   NOV54a   for the       Domain   Match Region   Matched Region   Expect Value               sushi   18 . . . 71   18/63 (29%)   2.9e−11               43/63 (68%)       sushi    79 . . . 132   15/63 (24%)     4e−11               41/63 (65%)       sushi   137 . . . 191   20/64 (31%)   1.4e−08               41/64 (64%)       sushi   196 . . . 251   21/65 (32%)   5.2e−14               46/65 (71%)       sushi   256 . . . 310   20/64 (31%)     4e−09               45/64 (70%)       sushi   395 . . . 445   18/62 (29%)   3.2e−07               39/62 (63%)       sushi   450 . . . 505   18/64 (28%)   1.4e−09               41/64 (64%)                  
 
     Example 55  
      The NOV55 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 55A.  
               TABLE 55A                       NOV55 Sequence Analysis                                                        NOV55a, CG59932-01   SEQ ID NO: 1121   1171 bp               DNA Sequence   ORF Start: at 2   ORF Stop: TAA at 1031                       G GAGGCCGCAAGGCCCTTCGCCCGGGAGTGGAGGGCCCAGTCCCTACCCCTGGCAGTAGGGGGCGTTT           TGAAGCTGCGGCTCTGTGAGCTGTGGCTACTGCTACTGGGTTCTAGTTTGAACGCCAGATTTTTGCCA       GACGAGGAGGACGTAGACTTTATCAACGAGTACGTGAACCTCCACAATGAGCTGCGGGGCGACGTTAT       TCCCCGAGGGTCTAACTTGCGCTTCATGACTTGGGATGTAGCTTTATCACGGACTGCTAGAGCATGGG       GAAAAAAATGTTTGTTTACGCATAATATTTATTTACAAGATGTACAAATGGTCCATCCTAAATTTTAT       GGTATTGGTGAAAATATGTGGGTCGGCCCTGAAAATGAATTTACTGCAAGTATTGCTATCAGAAGTTG       GCATGCAGAGAAGAAAATGTACAATTTTGAAAATGGCAGTTGCTCTGGAGACTGTTCTAATTATATTC       AGCTTGTTTGGGACCACTCTTACAAAGTTGGTTGTGCTGTTACTCCATGTTCAAAAATTGGACATATT       ATACATGCAGCAATTTTCATATGCAACTATGCGCCAGGAGGAACACTGACGAGAAGACCTTATGAACC       AGGAATATTTTGTACTCGATGTGGCAGACGTGACAAATGCACAGATTTTCTATGCAGTAATGCAGATC       GTGACCAAGCCACATATTACCGATTTTGGTATCCAAAATGGGAAATGCCCCGGCCAGTTGTGTGTGAT       CCACTGTGCACATTCATTTTATTATTGAGAATATTATGTTTTATCCTGTGTGTCATAACTGTTTTGAT       AGTACAGTCTCAGTTTCCAAATATCTTGTTGGAACAACAAATGATATTTACCCCTGAGGAATCTGAAG       CAGGGAATGAAGAGGAGGAAAAAGAGGAAGAGAAGAAAGAGAAAGAGGAAATGGAAATGGAAATAATG       GAAATGGAGGAGGAAAAAGAAGAGAGAGAGGAGGAGGAGGAGGAAACACAAAAAGAAAAGATGGAGGA       AGAGGAAAAA TAA   GAGTAGAAAGAGGAGGAAAAAGATGTATCACCAATATAAACCAAAAGTGTAATAC           AAAAAAAGACAGAAAAAAAAAAAAAGTAAAACACTGAGTTTTAACAAGAAAGAAAATATGCAAACCAC           CATTGGAATGTTTTT                                                   NOV55a, CG59932-01   SEQ ID NO: 1122   343 aa   MW at 40047.3kD               Protein Sequence                     EAARPFAREWRAQSLPLAVGGVLKLRLCELWLLLLGSSLNARFLPDEEDVDFINEYVNLHNELRGDVI           HAEKKMYNFENGSCSGDCSNYIQLVWDHSYKVGCAVTPCSKIGHIIHAAIFICNYAPGGTLTRRPYEP       GIFCTRCGRRDKCTDFLCSNADRDQATYYRFWYPKWEMPRPVVCDPLCTFILLLRILCFILCVITVLI       VQSQFPNILLEQQMIFTPEESEAGNEEEEKEEEKKEKEEMEMEIMEMEEEKEEREEEEEETQKEKMEE       EEK                  
 
      Further analysis of the NOV55a protein yielded the following properties shown in Table 55B.  
               TABLE 55B                       Protein Sequence Properties NOV55a                                        SignalP analysis:   Cleavage site between residues 42 and 43       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 11; pos. chg 3; neg. chg 2           H-region:   length 12; peak value 7.44           PSG score:   3.04                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −0.10           possible cleavage site: between 41 and 42                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 41)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 42           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 257-273               −13.43                             PERIPHERAL   Likelihood = 2.70 (at 172)                         ALOM score: −13.43 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 20           Charge difference: −1.0 C(1.0)-N(2.0)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 1a (cytoplasmic tail 274 to 343)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:    4   Hyd Moment(75):   9.56           Hyd Moment(95):   18.17   G content:   2           D/E content:    3   S/T content:   1                         Score: −4.20       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 11.4%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: AARP       none                 SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: found                         LL at 281                 checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 94.1       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions       290 E   1.00       291 E   1.00       292 S   1.00       293 E   1.00       294 A   1.00       295 G   1.00       296 N   1.00       297 E   1.00       298 E   1.00       299 E   1.00       300 E   1.00       301 K   1.00       302 E   1.00       303 E   1.00       304 E   1.00       305 K   1.00       306 K   1.00       307 E   1.00       308 K   1.00       309 E   1.00       310 E   1.00       311 M   1.00       312 E   1.00       313 M   1.00       314 E   1.00       315 I   1.00       316 M   1.00       317 E   1.00       318 M   1.00       319 E   1.00       320 E   1.00       321 E   1.00       322 K   1.00       323 E   1.00       324 E   1.00       325 R   1.00       326 E   1.00       327 E   1.00       328 E   1.00       329 E   1.00       330 E   1.00       331 E   1.00       332 T   1.00       333 Q   1.00       334 K   1.00       335 E   1.00       336 K   1.00       337 M   1.00       338 E   1.00       339 E   1.00       340 E   1.00       341 E   1.00       342 K   1.00           total: 53 residues                 Final Results (k = 9/23):                         55.6%: endoplasmic reticulum           22.2%: Golgi           11.1%: plasma membrane           11.1%: extracellular, including cell wall                 &gt;&gt; prediction for CG59932-01 is end (k = 9)                  
 
      A search of the NOV55a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 55C.  
               TABLE 55C                          Geneseq Results for NOV55a                                         NOV55a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value                                             ABP69108   Human polypeptide SEQ ID NO 1155 -    1 . . . 223   220/223   (98%)    e−134             Homo sapiens , 253 aa. [WO200270539-    2 . . . 224   222/223   (98%)           A2, 12-SEP-2002]       AAB64953   Human secreted protein sequence   45 . . . 222   177/178   (99%)    e−109           encoded by gene 12 SEQ ID NO: 131 -    1 . . . 178   177/178   (99%)             Homo sapiens , 178 aa. [WO200076530-           A1, 21-DEC-2000]       AAB43408   Human cancer associated protein   38 . . . 282   102/250   (40%)   6e−51           sequence SEQ ID NO: 853 -  Homo     55 . . . 300   143/250   (56%)             sapiens , 302 aa. [WO200055350-A1,           21-SEP-2000]       ABB53121   Human ORF27 protein -  Homo sapiens ,   94 . . . 178   85/85   (100%)   2e−48           85 aa. [WO200177155-A2, 18-OCT-2001]   1 . . . 85   85/85   (100%)       AAE18962   Mouse testes-specific, vespid and   37 . . . 282   96/247   (38%)   1e−46           pathogenic protein (RTVP) -  Mus  sp,   18 . . . 253   138/247   (55%)           255 aa. [WO200206344-A2, 24-JAN-2002]                  
 
      In a BLAST search of public sequence databases, the NOV55a protein was found to have homology to the proteins shown in the BLASTP data in Table 55D.  
               TABLE 55D                          Public BLASTP Results for NOV55a                                             Identities/           Protein       NOV55a   Similarities       Accession       Residues/   for the   Expect       Number   Protein/Organism/Length   Match Residues   Matched Portion   Value               Q8NA43   Hypothetical protein FLJ35856 -   1 . . . 228   228/228 (100%)   e−139             Homo sapiens  (Human), 229 aa.   2 . . . 229   228/228 (100%)       Q8N6N0   Similar to RIKEN cDNA 4921508O11   1 . . . 223   223/223 (100%)   e−135           gene -  Homo sapiens  (Human), 253   2 . . . 224   223/223 (100%)           aa.       Q9CQ35   4921508O11 Rik protein -  Mus     1 . . . 343   209/345 (60%)   e−117             musculus  (Mouse), 332 aa.   2 . . . 331   252/345 (72%)       P48060   Glioma pathogenesis-related protein   38 . . . 282    103/250 (41%)   1e−51            (GliPR) (RTVP-1 protein) -  Homo     19 . . . 264    144/250 (57%)             sapiens  (Human), 266 aa.       JC5308   testis-specific, vespid, and   38 . . . 282    103/250 (41%)   1e−51            pathogenesis-related protein 1   19 . . . 264    144/250 (57%)           precursor - human, 266 aa.                  
 
      PFam analysis predicts that the NOV55a protein contains the domains shown in the Table 55E.  
               TABLE 55E                          Domain Analysis of NOV55a                                             Identities/               Pfam   NOV55a   Similarities for   Expect           Domain   Match Region   the Matched Region   Value                       SCP   57 . . . 190   42/167 (25%)   3.1e−33                   95/167 (57%)                      
 
     Example 56  
      The NOV56 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 56A.  
               TABLE 56A                       NOV56 Sequence Analysis                                                NOV56a, CG92715-01   SEQ ID NO: 1123   2800 bp           DNA Sequence   ORF Start: ATG at 26   ORF Stop: end of sequence                       TAGACGCGGAGCCCAAGGAGGTAAA   ATG CACACTTGCTGCCCCCCAGTAACTTTGGAACAGGACCTTC           ACAGAAAAATGCATAGCTGGATGCTGCAGACTCTAGCGTTTGCTGTAACATCTCTCGTCCTTTCGTGT       GCAGAAACCATCGATTATTACGGGGAAATCTGTGACAATGCATGTCCTTGTGAGGAAAAGGACGGCAT       TTTAACTGTGAGCTGTGAAAACCGGGGGATCATCAGTCTCTCTGAAATTAGCCCTCCCCGTTTCCCAA       TCTACCACCTCTTGTTGTCCGGAAACCTTTTGAACCGTCTCTATCCCAATGAGTTTGTCAATTACACT       GGGGCTTCAATTTTGCATCTAGGTAGCAATGTTATCCAGGACATTGAGACCGGGGCTTTCCATGGGCT       ACGGGGTTTGAGGAGATTGCATCTAAACAATAATAAACTGGAACTTCTGCGAGATGATACCTTCCTTG       GCTTGGAGAACCTGGAGTACCTACAGGTCGATTACAACTACATCAGCGTCATTGAACCCAATGCTTTT       GGGAAACTGCATTTGTTGCAGGTGCTTATCCTCAATGACAATCTTTTGTCCAGTTTACCCAACAATCT       TTTCCGTTTTGTGCCCTTAACGCACTTGGACCTCCGGGGGAACCGGCTGAAACTTCTGCCCTACGTGG       GGCTCTTGCAGCACATGGATAAAGTTGTGGAGCTACAGCTGGAGGAAAACCCTTGGAATTGTTCTTGT       GAGCTGATCTCTCTAAAGGATTGGTTGGACAGCATCTCCTATTCAGCCCTGGTGGGGGATGTAGTTTG       TGAGACCCCCTTCCGCTTACACGGAAGGGACTTGGACGAGGTATCCAAGCAGGAACTTTGCCCAAGGA       GACTTATTTCTGACTACGAGATGAGGCCGCAGACGCCTTTGAGCACCACGGGGTATTTACACACCACC       CCGGCGTCAGTGAATTCTGTGGCCACTTCTTCCTCTGCTGTTTACAAACCCCCTTTGAAGCCCCCTAA       GGGGACTCGCCAACCCAACAAGCCCAGGGTGCGCCCCACCTCTCGGCAGCCCTCTAAGGACTTGGGCT       ACAGCAACTATGGCCCCAGCATCGCCTATCAGACCAAATCCCCGGTGCCTTTGGAGTGTCCCACCGCG       TGCTCTTGCAACCTGCAGATCTCTGATCTGGGCCTCAACGTAAACTGCCAGGAGCGAAAGATCGAGAG       CATCGCTGAACTGCAGCCCAAGCCCTACAATCCCAAGAAAATGTATCTGACAGAGAACTACATCGCTG       TCGTGCGCAGGACAGACTTCCTGGAGGCCACGGGGCTGGACCTCCTGCACCTGGGGAATAACCGCATC       TCGATGATCCAGGACCGCGCTTTCGGGGATCTCACCAACCTGAGGCGCCTCTACCTGAATGGCAACAG       GATCGAGAGGCTGAGCCCGGAGTTATTCTATGGCCTGCAGAGCCTGCAGTATCTCTTCCTCCAGTACA       ATCTCATCCGCGAGATTCAGTCTGGAACTTTTGACCCGGTCCCAAACCTCCAGCTGCTATTCTTGAAT       AACAACCTCCTGCAGGCCATGCCCTCAGGCGTCTTCTCTGGCTTGACCCTCCTCAGGCTAAACCTGAG       GAGTAACCACTTCACCTCCTTGCCAGTGAGTGGAGTTTTGGACCAGCTGAAGTCACTCATCCAAATCG       ACCTGCATGACAATCCTTGGGATTGTACCTGTGACATTGTGGGCATGAAGCTGTGGGTGGAGCAGCTC       AAAGTGGGCGTCCTAGTGGACGAGGTGATCTGTAAGGCGCCCAAAAAATTCGCTGAGACCGACATGCG       CTCCATTAAGTCGGAGCTGCTGTGCCCTGACTATTCAGATGTAGTAGTTTCCACGCCCACACCCTCCT       CTATCCAGGTCCCTGCGAGGACCAGCGCCGTGACTCCTGCGGTCCGGTTGAATAGCACCGGGGCCCCC       GCGAGCTTGGGCGCAGGCGGAGGGGCGTCGTCGGTGCCCTTGTCTGTGTTAATTCTCAGCCTCCTGCT       GGTTTTCATCATGTCCGTCTTCGTGGCCGCCGGGCTCTTCGTGCTGGTCATGAAGCGCAGGAAGAAGA       ACCAGAGCGACCACACCAGCACCAACAACTCCGACGTGAGCTCCTTTAACATGCAGTACAGCGTGTAC       GGCGGCGGCGGCGGCACGGGCGGCCACCCACACGCGCACGTGCATCACCGCGGGCCCGCGCTGCCCAA       GGTGAAGACGCCCGCGGGCCACGTGTATGAATACATCCCCCACCCACTGGGCCACATGTGCAAAAACC       CCATCTACCGCTCCCGAGAGGGCAACTCCGTAGAGGATTACAAAGACCTGCACGAGCTCAAGGTCACC       TACAGCAGCAACCACCACCTGCAGCAGCAGCAGCAGCCGCCGCCGCCACCGCAGCAGCCACAGCAGCA       GCCCCCGCCGCAGCTGCAGCTGCAGCCTGGGGAGGAGGAGAGGCGGGAAAGCCACCACTTGCGGAGCC       CCGCCTACAGCGTCAGCACCATCGAGCCCCGGGAGGACCTGCTGTCGCCGGTGCAGGACGCCGACCGC       TTTTACAGGGGCATTTTAGAACCAGACAAACACTGCTCCACCACCCCCGCCGGCAATAGCCTCCCGGA       ATATCCCAAATTCCCGTGCAGCCCCGCTGCTTACACTTTCTCCCCCAACTATGACCTGAGACGCCCCC       ATCAGTATTTGCACCCGGGGGCAGGGGACAGCAGGCTACGGGAACCGGTGCTCTACAGCCCCCCGAGT       GCTGTCTTTGTA                                                 NOV56a, CG92715-01   SEQ ID NO: 1124   925 aa   MW at 103516.1kD               Protein Sequence                     MHTCCPPVTLEQDLHRKMHSWMLQTLAFAVTSLVLSCAETIDYYGEICDNACPCEEKDGTLTVSCENR           GIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHL       NNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTH       LDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHG       RDLDEVSKQELCPRRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKP       RVRPTSRQPSKDLGYSNYGPSIAYQTKSPvPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKP       YNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPEL       FYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLP       VSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAETDMRSIKSELLC       PDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLGAGGGASSVPLSVLILSLLLVFIMSVFV       AAGLFVLVMKRRKKNQSDHTSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHV       YEYIPHPLGHMCKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQ       PGEEERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPKFPCSP       AAYTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFV                                             NOV56b, 248576233   SEQ ID NO: 1125   1872 bp               DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GGATCCATCGATTATTACGGGGAAATCTGTGACAATGCATGTCCTTGTGAGGAAAAGGACGGCATTTT           AACTGTGAGCTGTGAAAACCGGGGGATCATCAGTCTCTCTGAAATTAGCCCTCCCCGTTTCCCAATCT       ACCACCTCTTGTTGTCCGGAAACCTTTTGAACCGTCTCTATCCCAATGAGTTTGTCAATTACACTGGG       GCTTCAATTTTGCATCTAGGTAGCAATGTTATCCAGGACATTGAGACCGGGGCTTTCCATGGGCTACG       GGGTTTGAGGAGATTGCATCTAAACAATAATAAACTGGAACTTCTGCGAGATGATACCTTCCTTGGCT       TGGAGAACCCGGAGTACCTACAGGTCGATTACAACTACATCAGCGTCATTGAACCCAATGCTTTTGGG       AAACTGCATTTGTTGCAGGTGCTTATCCTCAATGACAATCTTTTGTCCAGTTTACCCAACAATCTTTT       CCGTTTTGTGCCCTTAACGCACTTGGACCTCCGGGGGAACCGGCTGAAACTTCTGCCCTACGTGGGGC       TCTTGCAGCACATGGATAAAGTTGTGGAGCTACAGCTGGAGGAAAACCCTTGGAATTGTTCTTGTGAG       CTGATCTCTCTAAAGGATTGGTTGGACAGCATCTCCTATTCAGCCCTGGTGGGGGATGTAGTTTGTGA       GACCCCCTTCCGCTTACACGGAAGGGACTTGGACGAGGTATCCAAGCAGGAACTTTGCCCAAGGAGAC       TTATTTCTGACTACGAGATGAGGCCGCAGACGCCTTTGAGCACCACGGGGTATTTACACACCACCCCG       GCGTCAGTGAATTCTGTGGCCACTTCTTCCTCTGCTGTTTACAAACCCCCTTTGAAGCCCCCTAAGGG       GACTCGCCAACCCAACAAGCCCAGGGTGCGCCCCACCTCTCGGCAGCCCTCTAAGGACTTGGGCTACA       GCAACTATGGCCCCAGCATCGCCTATCAGACCAAATCCCCGGTGCCTTTGGAGTGTCCCACCGCGTGC       TCTTGCAACCTGCAGATCTCTGATCTGGGCCTCAACGTAAACTGCCAGGAGCGAAAGATCGAGAGCAT       CGCTGAACTGCAGCCCAAGCCCTACAATCCCAAGAAAATGTATCTGACAGAGAACTACATCGCTGTCG       TGCGCAGGACAGACTTCCTGGAGGCCACGGGGCTGGACCTCCTGCACCTGGGGAATAACCGCATCTCG       ATGATCCAGGACCGCGCTTTCGGGGATCTCACCAACCTGAGGCGCCTCTACCTGAATGGCAACAGGAT       CGAGAGGCTGAGCCCGGAGTTATTCTATGGCCTGCAGAGCCTGCAGTATCTCTTCCTCCAGTACAATC       TCATCCGCGAGATTCAGTCTGGAACTTTTGACCCGGTCCCAAACCTCCAGCTGCTATTCTTGAATAAC       AACCTCCTGCAGGCCATGCCCTCAGGCGTCTTCTCTGGCTTGACCCTCCTCAGGCTAAACCTGAGGAG       TAACCACTTCACCTCCTTGCCAGTGAGTGGAGTTTTGGACCAGCTGAAGTCACTCATCCAAATCGACC       TGCATGACAATCCTTGGGATTGTACCTGTGACATTGTGGGCATGAAGCTGTGGGTGGAGCAGCTCAAA       GTGGGCGTCCTAGTGGACGAGGTGATCTGTAAGGCGCCCAAAAAATTCGCTGAGACCGACATGCGCTC       CATTAAGTCGGAGCTGCTGTGCCCTGACTATTCAGATGTAGTAGTTTCCACGCCCACACCCTCCTCTA       TCCAGGTCCCTGCGAGGACCAGCGCCGTGACTCCTGCGGTCCGGTTGAATAGCACCGGGGCCCCCGCG       AGCTTGGGCGCAGGCGGAGGGGCGTCGTCGCTCGAG                                                 NOV56b, 248576233   SEQ ID NO: 1126   624 aa   MW at 69694.9kD               Protein Sequence                     GSIDYYGEICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTG           ASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENPEYLQVDYNYISVIEPNAFG       KLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCSCE       LISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRLISDYEMRPQTPLSTTGYLHTTP       ASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNYGPSIAYQTKSPVPLECPTAC       SCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRIS       MIQDRAFGDLTNLRPLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNN       NLLQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLK       VGVLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPA       SLGAGGGASSLE                                             NOV56c, CG92715-02   SEQ ID NO: 1127   4500 bp               DNA Sequence   ORF Start: ATG at 178   ORF Stop: TAA at 3094                       CGGAACCCGCGGTCGCCACCGCGGCGGCGGCCCCAGGCTGGAGGCGTCCGGGCGCCTCTTTCCTCCAG               CCTCTGGGACTGCGCTGCTCGCAGTCTCCTCGCCCTGCCTGGGCTTGAGAAACCTAGTGCATACCCCA           AAGAGGGTTTTTGTGTATGTGTGTGTTTTTAAAGGGTGGCT   ATG ATGACTGGGCCTTGGAGACGCGGA       GACCAAGGAGGTAAAATGCACACTTGCTGCCCCCCAGTAACTTTGGAACAGGACCTTCACAGAAAAAT       GCATAGCTGGATGCTGCAGACTCTAGCGTTTGCTGTAACATCTCTCGTCCTTTCGTGTGCAGAAACCA       TCGATTATTACGGGGAAATCTGTGACAATGCATGTCCTTGTGAGGAAAAGGACGGCATTTTAACTGTG       AGCTGTGAAAACCGGGGGATCATCAGTCTCTCTGAAATTAGCCCTCCCCGTTTCCCAATCTACCACCT       CTTGTTGTCCGGAAACCTTTTGAACCGTCTCTATCCCAATGAGTTTGTCAATTACACTGGGGCTTCAA       TTTTGCATCTAGGTAGCAATGTTATCCAGGACATTGAGACCGGGGCTTTCCATGGGCTACGGGGTTTG       AGGAGATTGCATCTAAACAATAATAAACTGGAACTTCTGCGAGATGATACCTTCCTTGGCTTGGAGAA       CCTGGAGTACCTACAGGTCGATTACAACTACATCAGCGTCATTGAACCCAATGCTTTTGGGAAACTGC       ATTTGTTGCAGGTGCTTATCCTCAATGACAATCTTTTGTCCAGTTTACCCAACAATCTTTTCCGTTTT       GTGCCCTTAACGCACTTGGACCTCCGGGGGAACCGGCTGAAACTTCTGCCCTACGTGGGGCTCTTGCA       GCACATGGATAAAGTTGTGGAGCTACAGCTGGAGGAAAACCCTTGGAATTGTTCTTGTGAGCTGATCT       CTCTAAAGGATTGGTTGGACAGCATCTCCTATTCAGCCCTGGTGGGGGATGTAGTTTGTGAGACCCCC       TTCCGCTTACACGGAAGGGACTTGGACGAGGTATCCAAGCAGGAACTTTGCCCAAGGAGACTTATTTC       TGACTACGAGATGAGGCCGCAGACGCCTTTGAGCACCACGGGGTATTTACACACCACCCCGGCGTCAG       TGAATTCTGTGGCCACTTCTTCCTCTGCTGTTTACAAACCCCCTTTGAAGCCCCCTAAGGGGACTCGC       CAACCCAACAAGCCCAGGGTGCGCCCCACCTCTCGGCAGCCCTCTAAGGACTTGGGCTACAGCAACTA       TGGCCCCAGCATCGCCTATCAGACCAAATCCCCGGTGCCTTTGGAGTGTCCCACCGCGTGCTCTTGCA       ACCTGCAGATCTCTGATCTGGGCCTCAACGTAAACTGCCAGGAGCGAAAGATCGAGAGCATCGCTGAA       CTGCAGCCCAAGCCCTACAATCCCAAGAAAATGTATCTGACAGAGAACTACATCGCTGTCGTGCGCAG       GACAGACTTCCTGGAGGCCACGGGGCTGGACCTCCTGCACCTGGGGAATAACCGCATCTCGATGATCC       AGGACCGCGCTTTCGGGGATCTCACCAACCTGAGGCGCCTCTACCTGAATGGCAACAGGATCGAGAGG       CTGAGCCCGGAGTTATTCTATGGCCTGCAGAGCCTGCAGTATCTCTTCCTCCAGTACAATCTCATCCG       CGAGATTCAGTCTGGAACTTTTGACCCGGTCCCAAACCTCCAGCTGCTATTCTTGAATAACAACCTCC       TGCAGGCCATGCCCTCAGGCGTCTTCTCTGGCTTGACCCTCCTCAGGCTAAACCTGAGGAGTAACCAC       TTCACCTCCTTGCCAGTGAGTGGAGTTTTGGACCAGCTGAAGTCACTCATCCAAATCGACCTGCATGA       CAATCCTTGGGATTGTACCTGTGACATTGTGGGCATGAAGCTGTGGGTGGAGCAGCTCAAAGTGGGCG       TCCTAGTGGACGAGGTGATCTGTAAGGCGCCCAAAAAATTCGCTGAGACCGACATGCGCTCCATTAAG       TCGGAGCTGCTGTGCCCTGACTATTCAGATGTAGTAGTTTCCACGCCCACACCCTCCTCTATCCAGGT       CCCTGCGAGGACCAGCGCCGTGACTCCTGCGGTCCGGTTGAATAGCACCGGGGCCCCCGCGAGCTTGG       GCGCAGGCGGAGGGGCGTCGTCGGTGCCCTTGTCTGTGTTAATTCTCAGCCTCCTGCTGGTTTTCATC       ATGTCCGTCTTCGTGGCCGCCGGGCTCTTCGTGCTGGTCATGAAGCGCAGGAAGAAGAACCAGAGCGA       CCACACCAGCACCAACAACTCCGACGTGAGCTCCTTTAACATGCAGTACAGCGTGTACGGCGGCGGCG       GCGGCACGGGCGGCCACCCACACGCGCACGTGCATCACCGCGGGCCCGCGCTGCCCAAGGTGAAGACG       CCCGCGGGCCACGTGTATGAATACATCCCCCACCCACTGGGCCACATGTGCAAAAACCCCATCTACCG       CTCCCGAGAGGGCAACTCCGTAGAGGATTACAAAGACCTGCACGAGCTCAAGGTCACCTACAGCAGCA       ACCACCACCTGCAGCAGCAGCAGCAGCCGCCGCCGCCACCGCAGCAGCCACAGCAGCAGCCCCCGCCG       CAGCTGCAGCTGCAGCCCGGGGAGGAGGAGAGGCGGGAAAGCCACCACTTGCGGAGCCCCGCCTACAG       CGTCAGCACCATCGAGCCCCGGGAGGACCTGCTGTCGCCGGTGCAGGACGCCGACCGCTTTTACAGGG       GCATTTTAGAACCAGACAAACACTGCTCCACCACCCCCGCCGGCAATAGCCTCCCGGAATATCCCAAA       TTCCCGTGCAGCCCCGCTGCTTACACTTTCTCCCCCAACTATGACCTGAGACGCCCCCATCAGTATTT       GCACCCGGGGGCAGGGGACAGCAGGCTACGGGAACCGGTGCTCTACAGCCCCCCGAGTGCTGTCTTTG       TAGAACCCAACCGGAACGAATATCTGGAGTTAAAAGCAAAACTAAACGTTGAGCCGGACTACCTCGAA       GTGCTGGAAAAACAGACCACGTTTAGCCAGTTC TAA   AAGCAAAGAAACTCTCTTGGAGCTTTTGCATT           TAAAACAAACAAGCAAGCAGACACACACAGTGAACACATTTGATTAATTGTGTTGTTTCAACGTTTAG           GGTGAAGTGCCTTGGCACGGGATTTCTCAGCTTCGGTGGAAGATACGAAAAGGGTGTGCAATTTCCTT           TAAAATTTACACGTGGGAAACATTTGTGTAAACTGGGCACATCACTTTCTCTTCTTGCGTGTGGGGCA           GGTGTGGAGAAGGGCTTTAAGGAGGCCAATTTGCTGCGCGGGTGACCTGTGAAAGGTCACAGTCATTT           TTGTAGTGGTTGGAAGTGCTAAGAATGGTGGATGATGGCAGAGCATAGATTCTACTCTTCCTCTTTAG           CTTCCTCCCCATCCAACGAACCCTGCCCAACACTCTAAATATCCACCAGATAAGACATGGAATGAGGT           CTAAATGACACAAAGTGAAGAAATCAACACAACACAAACTTTACAGCTAACAACAAATGATCAACAAA           AACCGAACCAACAAGACAACCATCGAACCTCACCACTCCACACTCACAACAACTCATATCAAGACAAC           AACACAATGACGTTAAAGGAAACGAAATCAATGCAAAAATAGACATTTGACAATACAAAAAAACAAGA           ACCGTGATCACACTACAACCGAAGCAACCATAGATGTGAGAAAAAACAACAAACAAAACACCGAGCTA           TATGATCCATAATTGATTAGTCAAAATAACTTATTGATGAAATATACAAATATTTTATTGTAGCACCT           ATTTTTATATGCACATTTAGCATTCCTCTTTCCTTCACTATTTAGCCTATGATTTTGCAGAGGTGTCA           CACTGTATTAGGATCTGCATTTCTAAAACTGACGTGGTATCAGGAAGGCATTTTCAATCATTCAAAAT           GTGGAGAATTTAATGGCTAAATCTTTAAAAGCCAATGCAACCCACCCAATTGAATCTGCATTTTCTTT           TAAGAAAACAGAGCTGATTGTATCCCAATGTATTTTAAAAAATAGGGCAATTGATTGGGCCATTCCGA           GAGAATTGTTTGCAAGTTTTGGGTTTTATTAGAAAATATTTGAAAGTATTTTTATTAATGAACCAAAA           TGACATGTTCATTTGACTACTATTGTAGCCGATTTTCGATTGTTTAACCAAACCCAGTTGCATTTGTA           CAGATCCACGTGTACTGGCACCTCAGAAGACCAAATCATGGACTGTACAAGTCTCTATACAATGTCTT           TATCCCTGTGGGCAGCAAGCAATGATGATAATGACAAACAGGATATCTGTAAGATGGGGCTACTGTTG           TTACAGTCTCATATGTATCCCAGCACATGTAATTTTTTAAATAGTTTCTGAATAAACACTTGATAACT           ATGTCAAAAAAA                                                   NOV56c, CG92715-02   SEQ ID NO: 1128   972 aa   MW at 109043.3kD               Protein Sequence                     MMTGPWRRGDQGGKMHTCCPPVTLEQDLHRKMHSWMLQTLAFAVTSLVLSCAETIDYYGEICDNACPC           EEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIET       GAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLS       SLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHNDKVVELQLEENPWNCSCELISLKDWLDSISYSAL       VGDVVCETPFRLHGRDLDEVSKQELCPRRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKP       PLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQ       ERKIESIAELQPKPYNPKKNYLTENYIAVVRRTDFLEATGLDLLHLGNNRTSMIQDRAFGDLTNLRRL       YLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTL       LRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKF       AETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLGAGGGASSVPLSVL       ILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHR       GPALPKVKTPAGHVYEYIPHPLGHMCKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPP       QQPQQQPPPQLQLQPGEEERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPA       GNSLPEYPKFPCSPAAYTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAK       LNVEPDYLEVLEKQTTFSQF                                             NOV56d, CG92715-03   SEQ ID NO: 1129   1872 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 1867                       GGATCC ATCGATTATTACGGGGAAATCTGTGACAATGCATGTCCTTGTGAGGAAAAGGACGGCATTTT           AACTGTGAGCTGTGAAAACCGGGGGATCATCAGTCTCTCTGAAATTAGCCCTCCCCGTTTCCCAATCT       ACCACCTCTTGTTGTCCGGAAACCTTTTGAACCGTCTCTATCCCAATGAGTTTGTCAATTACACTGGG       GCTTCAATTTTGCATCTAGGTAGCAATGTTATCCAGGACATTGAGACCGGGGCTTTCCATGGGCTACG       GGGTTTGAGGAGATTGCATCTAAACAATAATAAACTGGAACTTCTGCGAGATGATACCTTCCTTGGCT       TGGAGAACCTGGAGTACCTACAGGTCGATTACAACTACATCAGCGTCATTGAACCCAATGCTTTTGGG       AAACTGCATTTGTTGCAGGTGCTTATCCTCAATGACAATCTTTTGTCCAGTTTACCCAACAATCTTTT       CCGTTTTGTGCCCTTAACGCACTTGGACCTCCGGGGGAACCGGCTGAAACTTCTGCCCTACGTGGGGC       TCTTGCAGCACATGGATAAAGTTGTGGAGCTACAGCTGGAGGAAAACCCTTGGAATTGTTCTTGTGAG       CTGATCTCTCTAAAGGATTGGTTGGACAGCATCTCCTATTCAGCCCTGGTGGGGGATGTAGTTTGTGA       GACCCCCTTCCGCTTACACGGAAGGGACTTGGACGAGGTATCCAAGCAGGAACTTTGCCCAAGGAGAC       TTATTTCTGACTACGAGATGAGGCCGCAGACGCCTTTGAGCACCACGGGGTATTTACACACCACCCCG       GCGTCAGTGAATTCTGTGGCCACTTCTTCCTCTGCTGTTTACAAACCCCCTTTGAAGCCCCCTAAGGG       GACTCGCCAACCCAACAAGCCCAGGGTGCGCCCCACCTCTCGGCAGCCCTCTAAGGACTTGGGCTACA       GCAACTATGGCCCCAGCATCGCCTATCAGACCAAATCCCCGGTGCCTTTGGAGTGTCCCACCGCGTGC       TCTTGCAACCTGCAGATCTCTGATCTGGGCCTCAACGTAAACTGCCAGGAGCGAAAGATCGAGAGCAT       CGCTGAACTGCAGCCCAAGCCCTACAATCCCAAGAAAATGTATCTGACAGAGAACTACATCGCTGTCG       TGCGCAGGACAGACTTCCTGGAGGCCACGGGGCTGGACCTCCTGCACCTGGGGAATAACCGCATCTCG       ATGATCCAGGACCGCGCTTTCGGGGATCTCACCAACCTGAGGCGCCTCTACCTGAATGGCAACAGGAT       CGAGAGGCTGAGCCCGGAGTTATTCTATGGCCTGCAGAGCCTGCAGTATCTCTTCCTCCAGTACAATC       TCATCCGCGAGATTCAGTCTGGAACTTTTGACCCGGTCCCAAACCTCCAGCTGCTATTCTTGAATAAC       AACCTCCTGCAGGCCATGCCCTCAGGCGTCTTCTCTGGCTTGACCCTCCTCAGGCTAAACCTGAGGAG       TAACCACTTCACCTCCTTGCCAGTGAGTGGAGTTTTGGACCAGCTGAAGTCACTCATCCAAATCGACC       TGCATGACAATCCTTGGGATTGTACCTGTGACATTGTGGGCATGAAGCTGTGGGTGGAGCAGCTCAAA       GTGGGCGTCCTAGTGGACGAGGTGATCTGTAAGGCGCCCAAAAAATTCGCTGAGACCGACATGCGCTC       CATTAAGTCGGAGCTGCTGTGCCCTGACTATTCAGATGTAGTAGTTTCCACGCCCACACCCTCCTCTA       TCCAGGTCCCTGCGAGGACCAGCGCCGTGACTCCTGCGGTCCGGTTGAATAGCACCGGGGCCCCCGCG       AGCTTGGGCGCAGGCGGAGGGGCGTCGTCGCTC GAG                                                   NOV56d, CG92715-03   SEQ ID NO: 1130   620 aa   MW at 69324.6kD               Protein Sequence                     IDYYGEICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGAS           ILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKL       HLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCSCELI       SLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRLISDYEMRPQTPLSTTGYLHTTPAS       VNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNYGPSIAYQTKSPVPLECPTACSC       NLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMI       QDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNL       LQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVG       VLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASL       GAGGGASS                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 56B.  
               TABLE 56B                       Comparison of the NOV56 protein sequences.                                        NOV56b VDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNST           NOV56c VDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNST       NOV56d VDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNST               NOV56a GAPASLGAGGGASSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTSTNNSD       NOV56b GAPASLGAGGGASSLE--------------------------------------------       NOV56c GAPASLGAGGGASSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTSTNNSD       NOV56d GAPASLGAGGGASS----------------------------------------------               NOV56a VSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHMCKNPIYR       NOV56b ------------------------------------------------------------       NOV56c VSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHMCKNPIYR       NOV56d ------------------------------------------------------------               NOV56a SREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGEEERRESH       NOV56b ------------------------------------------------------------       NOV56c SREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGEEERRESH       NOV56d ------------------------------------------------------------               NOV56a HLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPKFPCSPAA       NOV56b ------------------------------------------------------------       NOV56c HLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPKFPCSPAA       NOV56d ------------------------------------------------------------               NOV56a YTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFV---------------------       NOV56b ------------------------------------------------------------       NOV56c YTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKLNVEPDYL       NOV56d ------------------------------------------------------------               NOV56a ------------       NOV56b ------------       NOV56c EVLEKQTTFSQF       NOV56d ------------               NOV56a (SEQ ID NO: 1124)       NOV56b (SEQ ID NO: 1126)       NOV56c (SEQ ID NO: 1128)       NOV56d (SEQ ID NO: 1130)                  
 
      Further analysis of the NOV56a protein yielded the following properties shown in Table 56C.  
               TABLE 56C                       Protein Sequence Properties NOV56a                                        SignalP analysis:   Cleavage site between residues 41 and 42       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 11; pos. chg 0; neg. chg 1           H-region:   length 1; peak value 0.00           PSG score:   −4.40                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −2.49           possible cleavage site: between 38 and 39                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 2           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 665-681               −13.59                             PERIPHERAL   Likelihood = 2.44 (at 571)                         ALOM score: −13.59 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 672           Charge difference: 2.5 C(4.5)-N(2.0)           C &gt; N: C-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 1b (cytoplasmic tail 665 to 925)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   2.75           Hyd Moment(95):   4.92   G content:   0           D/E content:   2   S/T content:   2                         Score: −7.05       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: KRRK (5) at 690           pat4: RRKK (5) at 691           pat7: none           bipartite: none           content of basic residues: 9.2%           NLS Score: 0.15       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: found                         LL at 670       LL at 671                 checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         69.6%: nuclear            8.7%: mitochondrial            8.7%: cytoplasmic            4.3%: vacuolar            4.3%: plasma membrane            4.3%: vesicles of secretory system                 &gt;&gt; prediction for CG92715-01 is nuc (k = 23)                  
 
      A search of the NOV56a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 56D.  
               TABLE 56D                          Geneseq Results for NOV56a                                         NOV56a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value                                             ABU12071   Human NOV16b CG92715-02 protein   1 . . . 925   925/925   (100%)   0.0           SEQ ID 62 -  Homo sapiens , 972 aa.   15 . . . 939    925/925   (100%)           [WO200281625-A2, 17-OCT-2002]       ABU12070   Human NOV16a CG92715-01 protein   1 . . . 925   925/925   (100%)   0.0           SEQ ID 60 -  Homo sapiens , 925 aa.   1 . . . 925   925/925   (100%)           [WO200281625-A2, 17-OCT-2002]       AAU98780   Human haematopoietic cell line Kg-1a   1 . . . 925   925/925   (100%)   0.0           protein KIAA0918 -  Homo sapiens , 958   1 . . . 925   925/925   (100%)           aa. [WO200236804-A2, 10-MAY-2002]       AAB95753   Human protein sequence SEQ ID   1 . . . 925   925/925   (100%)   0.0           NO: 18665 -  Homo sapiens , 958 aa.   1 . . . 925   925/925   (100%)           [EP1074617-A2, 07-FEB-2001]       ABB12025   Human IGFALS homologue, SEQ ID   1 . . . 925   924/925   (99%)   0.0           NO: 2395 -  Homo sapiens , 977 aa.   20 . . . 944    924/925   (99%)           [WO200157188-A2, 09-AUG-2001]                  
 
      In a BLAST search of public sequence databases, the NOV56a protein was found to have homology to the proteins shown in the BLASTP data in Table 56E.  
               TABLE 56E                          Public BLASTP Results for NOV56a                                         NOV56a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             O94991   Hypothetical protein KIAA0918 -   1 . . . 925   925/925   (100%)   0.0             Homo sapiens  (Human), 966 aa   9 . . . 933   925/925   (100%)           (fragment).       CAD48653   Sequence 18 from Patent   22 . . . 925    904/904   (100%)   0.0           WO0220569 -  Homo sapiens     1 . . . 904   904/904   (100%)           (Human), 937 aa.       BAC67208   Neuronal transmembrane protein   1 . . . 925   895/926   (96%)   0.0           Slitrk5 -  Mus musculus  (Mouse),   1 . . . 924   908/926   (97%)           957 aa.       Q9H156   BG115M3.1 (Novel protein)   46 . . . 925    423/886   (47%)   0.0           (SLITL1 protein) -  Homo sapiens     27 . . . 812    563/886   (62%)           (Human), 845 aa.       Q8NBC7   Hypothetical protein FLJ33696 -   46 . . . 781    393/742   (52%)   0.0             Homo sapiens  (Human), 724 aa   27 . . . 717    511/742   (67%)           (fragment).                  
 
      PFam analysis predicts that the NOV56a protein contains the domains shown in the Table 56F.  
               TABLE 56F                          Domain Analysis of NOV56a                                                     Identities/               Pfam   NOV56a Match       Similarities for   Expect           Domain   Region       the Matched Region   Value                                                     LRR   154 . . . 177   8/25   (32%)   0.053                   21/25   (84%)           LRRCT   235 . . . 285   18/54   (33%)   2.7e−08                   34/54   (63%)           LRRNT   373 . . . 406   10/36   (28%)   0.0099                   19/36   (53%)           LRR   434 . . . 457   8/25   (32%)   0.28                   17/25   (68%)           LRR   458 . . . 481   12/25   (48%)   0.0022                   23/25   (92%)           LRR   482 . . . 505   5/25   (20%)   0.59                   19/25   (76%)           LRR   506 . . . 529   12/25   (48%)   0.0077                   19/25   (76%)           LRRCT   563 . . . 613   10/54   (19%)   1.9e−05                   36/54   (67%)                      
 
     Example 57  
      The NOV57 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 57A.  
               TABLE 57A                       NOV57 Sequence Analysis                                                NOV57a, CG92813-01   SEQ ID NO: 1131   15603 bp           DNA Sequence   ORF Start: ATG at 518   ORF Stop: TGA at 15401                       CTAATAGAATTCAGCGGCCGCTTTCCCCGGTGCGCAGTTGTGCTTGGACGTTTGTTCCTCCCTCTTCA               CGCTCTTCGCTGCGGGTAAGTTCTAAAGTTTCTGAAGGCCGTTCTTTGCAATGATTCCTCATATACCT           TAGATACAGGCAACTTCTCCCAACTCTCATCCACCCGGGTGAAAACGCTCAGACTATCTGGATTCAAA           AACAAAGTAAAAGGGGGCATATATAAGAGGCTTGAGAAACTTTTCTGGGAACTCAGCTCACAGGAGTG           TCCCGCGGAATGCCCTGCCGCTTTTCGCCACAGCATCTCTCTTGCACTCCGCGTTCAACTGGCTACCT           AGAGTCTTTTGCTGATGCTACTTGCTTTTGCCGGACTGGAGGTTCTTTGAAATAGCAGAGGTCTCAGA           CCAAGCCGTCAGCTGAATCTTTGCTGGCGCTCCTTAATCCCTGTAAATATCATTGCGTTTGCTTCACC           CCTTCCTTCTCTTTATCACATCGTTTTAGGGAGCCAGGACC   ATG GACTTAGCACCAGACAGGGCTACT       GGCCGCCCGTGGCTCCCGTTGCACACTCTATCAGTATCTCAGCTCCTTCGAGTGTTTTGGCTACTGTC       ATTGCTTCCGGGGCAGGCCTGGGTCCACGGGGCCGAGCCGCGCCAGGTGTTCCAAGTGCTGGAAGAGC       AACCTCCAGGCACTCTGGTAGGCACCATCCAGACGCGCCCCGGCTTCACCTACAGGCTCAGCGAAAGC       CACGCCCTGTTTGCCATAAACAGTAGCACCGGAGCCCTGTACACCACCTCCACCATCGACCGCGAGAG       CCTGCCCAGCGACGTGATCAACCTGGTGGTCCTTTCCAGCGCGCCCACCTACCCCACCGAAGTGCGAG       TGCTGGTGCGGGACCTCAATGACAACGCCCCCGTTTTCCCGGACCCCTCTATCGTGGTCACTTTCAAG       GAAGACAGTAGCAGCGGACGCCAAGTCATCTTAGACACCGCCACCGACTCGGACATCGGCTCAAACGG       TGTGGACCACCGCTCCTACCGCATCATCCGCGGCAATGAGGCGGGGCGCTTCCGTCTGGACATCAACC       TGAACCCGAGCGGCGAGGGAGCGTTCCTGCATCTGGTGTCCAAGGGCGGACTGGACCGTGAGGTCACT       CCGCAGTACCAGCTCCTGGTTGAGGTGGAGGACAAGGGTGAGCCTAAGCGGCGGGGCTACCTTCAGGT       AAACGTGACTGTGCAAGACATTAATGACAACCCCCCGGTTTTTGGCAGTTCTCACTACCAGGCGGGGG       TGCCTGAGGACGCGGTTGTGGGTTCCAGCGTCCTCCAGGTGGCGGCGGCGGACGCGGACGAGGGCACC       AACGCGGACATCCGCTATCGCCTGCAGGACGAGGGGACCCCCTTCCAAATGGACCCTGAGACGGGACT       TATCACGGTGCGGGAGCCCCTGGACTTCGAAGCTCGGCGCCAATACTCGCTTACGGTGCAGGCGATGG       ACAGAGGCGTGCCTTCCCTCACTGGGCGCGCCGAGGCGCTGATTCAGCTGCTGGACGTGAATGACAAT       GACCCGGTAGTGAAGTTCCGCTACTTCCCGGCCACCTCGOGCTACGCCTCGGTAGATGAGAATGCTCA       AGTGGGCACCGTGGTGGCTCTGCTCACCGTGACGGACGCAGATTCTCCCGCGGCCAACGGGAACATCT       CCGTGCAAATTCTCGGGGGCAATGAGCAGCGCCACTTTGAAGTGCAAAGCAGCAAAGTGCCGAACCTG       AGCCTAATCAAGGTGGCCAGCGCCTTGGACCGCGAGCGCATCCCTTCCTACAACCTCACAGTTTCCGT       CTCTGATAACTACGGGGCGCCCCCTGGCGCAGCAGTCCAGGCGCGCTCTTCTGTGGCAAGCCTGGTGA       TTTTTGTTAATGACATCAATGACCATCCTCCTGTCTTTTCACAGCAAGTGTACAGAGTGAACCTGAGC       GAGGAGGCGCCTCCGGGAAGCTATGTGAGTGGGATATCTGCCACTGATGGCGACTCTGGTCTCAATGC       TAATCTGCGTTACAGCATTGTCTCTGGCAATGGACTGGGATGGTTCCATATCAGTGAACATAGCGGCC       TCGTGACCACTGGGTCCTCTGGGGGCCTGGACCGTGAACTTGCTTCCCAGATTGTTCTGAATATAAGT       GCCCGGGACCAGGGAGTTCACCCCAAGGTGTCCTATGCCCAGCTTGTAGTAACTCTCCTAGATGTGAA       TGATGAAAAGCCAGTATTTAGCCAGCCAGAAGGGTATGATGTGTCTGTGGTTGAGAATGCCCCAACAG       GGACAGAACTGTTGATGCTCAGGGCAACTGACGGGGACCTGGGTGACAACGGAACAGTGCGCTTCTCC       TTACAAGAGGCAGAGACTGACCGGAGGTCCTTCCGTCTGGATCCTGTGTCTGGGAGGTTGAGTACTAT       TTCCTCCTTGGACAGAGAAGAGCAAGCCTTCTACTCCCTGTTGGTTCTGGCCACAGATCTGGGCTCCC       CTCCCCAGTCATCAATGGCTCGCATAAATGTGAGTCTTCTGGATATAAATGATAACAGCCCTGTCTTC       TACCCGGTCCAATACTTTGCTCACATTAAGGAGAATGAGCCTGGAGGTAGCTACATCACCACTGTGTC       TGCCACTGACCCAGACTTGGGTACCAATGGTACTGTCAAATATAGCATATCTGCTGGGGACAGGTCTC       GGTTTCAGGTCAATGCTCAGAGTGGGGTTATTTCTACAAGAATGGCCCTAGACAGAGAAGAAAAAACA       GCTTATCAGTTGCAAATAGTAGCTACTGATGGTGGCAATTTACAATCTCCCAACCAGGCAATAGTAAC       CATCACTGTATTGGACACTCAAGACAACCCACCTGTATTCAGTCAGGTTGCCTACAGCTTTGTGGTTT       TTGAGAACGTGGCGCTGGGATATCATGTGGGTAGTGTGTCTGCATCCACCATGGATCTCAATTCCAAC       ATCAGTTATCTCATTACTACTGGGGATCAGAAAGGTATGTTTGCTATCAACCAGGTCACTGGGCAGCT       TACCACAGCAAATGTGATTGATAGAGAAGAGCAATCCTTTTATCAGCTGAAGGTAGTGGCCAGTGGGG       GCACAGTGACTGGAGACACTATGGTTAACATAACAGTTAAGGATTTGAATGACAACTCTCCCCATTTC       CTTCAGGCAATAGAGAGTGTAAATGTGGTGGAGAATTGGCAGGCAGGTCACAGCATTTTCCAGGCCAA       AGCTGTGGACCCTGATGAAGGTGTCAATGGCATGGTACTCTATAGTCTGAAGCAAAACCCCAAGAACC       TGTTTGCTATCAATGAAAAGAATGGCACTATTAGTCTGCTTGGGCCCCTGGATGTTCATGCTGGCTCC       TACCAAATAGAGATCTTGGCATCTGACATGGGTGTCCCACAGCTCTCCTCTAGTGTCATCCTAACAGT       TTATGTCCATGATGTAAATGACAATTCACCAGTGTTTGACCAACTCTCTTATGAAGTCACCCTTTCTG       AGTCAGAACCTGTGAATTCTCGATTCTTTAAAGTACAAGCTTCTGATAAGGATTCAGGAGCAAATGAT       GGTCAATTGTATATAAAAAGTGAACTGGACCGTGAACTTCAAGACAGATATGTTTTAATGGTTGTTGC       TTCTGACAGAGCAGTGGAACCCCTTAGTGCTACTGTGAATGTTACTGTAATTTTAGAAGATGTAAATG       ATAACAGACCTCTTTTTAACAGTACCAATTACACATTTTACTTCGAAGAAGAGCAGAGGGCTGGGTCG       TTTGTGGGCAAAGTAAGTGCTGTAGATAAAGACTTTGGGCCAAATGGAGAAGTAAGGTATTCTTTTGA       AATGGTGCAGCCAGATTTTGAGTTGCATGCCATCAGTGGGGAAATTACAAATACTCATCAGTTTGACA       GGGAGTCTCTTATGAGGCGGAGAGGGACTGCTGTGTTTAGCTTTACAGTCATAGCAACAGATCAGGGG       ATCCCTCAGCCTCTCAAGGATCAGGCCACTGTACATGTTTACATGAAGGATATAAATGATAATGCTCC       CAAATTTTTAAAAGACTTTTACCAAGCTACAATATCAGAATCAGCAGCCAATCTGACACAAGTGTTAA       GAGTATCTGCCTCAGATGTTGATGAAGGTAATAATGGACTTATTCACTATTCTATAATAAAAGGAAAT       GAAGAAAGACAGTTTGCTATAGACAGTACCTCTGGTCAGGTAACACTAATTGGCAAATTAGACTATGA       AGCAACACCTGCCTATTCCCTTGTAATTCAAGCAGTGGATTCAGGGACAATCCCCCTCAATTCAACGT       GTACTTTAAATATTGATATTTTAGATGAAAATGACAATACCCCTTCTTTCCTTAAATCAACACTGTTT       GTTGATGTTTTGGAAAACATGAGAATTGGTGAACTCGTGTCCTCTGTTACTGCAACTGATTCCGATTC       AGGTGACAATGTTGATTTATATTACAGTATTACTGGGACTAACAACCACGGAACTTTTAGCATTAGCC       CAAACACTGGGAGTATTTTTCTTGCCAAAAAACTGGACTTTGAAACACAGTCTTTGTATAAATTAAAT       ATAACAGCAAAAGACCAAGGAAGACCTCCTCGTTCATCTACAATGTCAGTGGTTATTCACGTGAGGGA       CTTTAATGACAATCCTCCTAGCTTTCCTCCTGGAGATATTTTCAAGTCTATTGTTGAGAACATTCCCA       TTGGTACATCTGTCATTTCAGTGACTGCACATGACCCTGATGCAGACATTAATGGTCAACTATCCTAC       ACAATCATTCAACAGATGCCAAGAGGCAACCACTTTACCATAGATGAAGTCAAAGGGACTATATATAC       TAATGCTGAAATAGATCGGGAATTTGCTAATCTCTTTGAGTTGACTGTAAAAGCCAATGATCAAGCTG       TGCCAATAGAAACTAGACGGTATGCTTTGAAGAACGTGACCATTTTGGTTACAGACCTCAATGACAAT       GTCCCAATGTTTATATCACAAAACGCCCTTGCTGCAGACCCATCAGCTGTGATTGGTTCCGTTCTGAC       AACAATTATGGCTGCTGACCCAGATGAAGGTGCTAATGGAGAAATAGAGTATGAGATCATCAATGGGG       ACACAGACACCTTCATTGTTGATCGTTATAGTGGAGACCTGAGAGTGGCTTCAGCGTTGGTGCCTTCA       CAGTTGATCTACAATCTCATAGTTTCAGCAACAGACCTTGGGCCTGAAAGGAGGAAATCGACCACTGA       ATTGACCATCATTCTTCAGGGCCTTGATGGACCTGTTTTTACTCAACCCAAATATATAACTATTTTGA       AGGAAGGAGAACCCATTGGCACAAACGTGATATCAATAGAAGCAGCTAGCCCCAGAGGATCTGAGGCC       CCAGTGGAGTATTATATTGTTTCAGTTCGTTGTGAAGAAAAAACTGTTGGACGCCTCTTTACTATTGG       ACGACATACTGGTATAATTCAGACCGCAGCCATTCTGGACCGGGAGCAAGGAGCATGTCTTTACCTGG       TGGATGTTTATGCCATAGAAAAATCAACTGCTTTTCCCAGAACACAGAGAGCAGAGGTAGAAACAACA       CTTCAGGATATCAATGACAATCCACCAGTATTTCCAACGGACATGCTGGATCTCACGGTAGAGGAGAA       CATTGGAGATGGCTCTAAGATTATGCAGCTGACAGCCATGGATGCTGACGAGGTGCAAATGCTCTCGT       CACATACACTATCATTAGTGGGTTCTTTGGTAGCAGCCATTTTAGCCACGGATGATGACTCTGGTGTG       AATGGAGAAATTACATATATTGTGAATGAAGATGATGAAGATGGCATCTTTTTCCTGAATCCTATTAC       TGGGGTCTTTAATTTGACTCGATTATTAGATTATGAAGTACAGCAATATTATATCCTCACTGTTCGAG       CAGAAGATGGTGGGGGACAATTTACTACCATCAGAGTTTATTTCAATATTCTAGATGTAAATGATAAT       CCACCTATTTTCAGCTTGAATTCATACAGCACATCTTTAATGGAGAATCTACCTGTGGGATCTACTGT       TCTTGTGTTTAATGTTACTGATGCAGATATGATGAAGGCAGAAATAAAGATGTTCTTTGAAACCAGTG       AGAACAAAGACACAACATACCAGAATCTCTGGGACACATTCAAAGCAGTGTGTAGAGGGAAATTTATA       GCACTAAATGCCCACAAGAGAAAGCAGGAAAGATCCAAAATTGACACCCTAACATCACAATTAAAAGA       ACTAGAAAAGCAAGAGCAAACACATTCAAAAGCTAGCAGAAGGCAAGAAATAACTAAAATCAGAGCAG       AACTGAAGGATATAGAGACACAAAAAACCCTTCAAAAAATTAATGAATCCAGGAGCTGGTTTTTTGAA       AGGATCAACAAAATTGATAGACCGCTAGCAAGACTAATAAAGAAGAAAACAGAGAAGAATCAAATAGA       CGCAATAAAAAATGATAAAGGGGATATCACCATCGATCCCACAGAAATACAAACTACCATCAGAGAAT       ACTGCAAACACCTCTATGCAAATAAACTAGAAAATCTAGAAGAAATGGATAAATTCCTCGACACATAC       ACCCTCCCAAGACTAAACCAGGAAGAAGTTGAATCTCTGAATAGACCAATAACAGACTCTGAAACTGT       GGCAATAATCAATAGCTTACCAACCAAAAAGAGTCCAGGACCAGATGGATTCACAGCCGAATTCTACC       AGATGATAACAACCCCAGTCTTTGCACAAGCTTTGTATAAAGTGGAGATTAATGAAAACACACTTACT       GGAACAGATATAATACAAGTGTTCGCAGCAGATGGAGATGAAGGCACAAATGGACAGGTTCGCTATGG       CATTGTTAATGGTAATACCAATCAGGAATTTCGGATAGACTCTGTCACAGGTGCCATCACTGTCGCTA       AACCTTTGGATAGAGAAAAGACCCCTACCTACCATTTAACTGTTCAGGCAACAGATCGAGGCAGCACA       CCCAGAACTGATACCTCCACGGTCAGCATTGTTCTACTGGATATTAATGACTTTGTTCCTGTATTTGA       GCTATCTCCATATTCTGTAAATGTCCCTGAGAATTTAGGGACACTACCCAGAACAATTCTTCAGACTG       CTTCGCCTTGCGTGAGGTTTGCCAGCGCCAGTAAAGCGTATTTCACAACAATTCCTGAGGATGCACCA       ACTGGAACAGATGTTTTATTGGTAAATGCCTCAGATGCTGATGCTTCAAAGAATGCAGTTATAAGTTA       TAGGATCATCGGTGGAAACTCTCAGTTCACGATCAACCCATCGACAGGACAAATCATCACCAGCGCAT       TGTTAGATAGGGAAACAAAAGATAATTATACTTTGGTAGTGGTCTGCAGTGATGCGGGATCCCCAGAG       CCTCTTTCCAGTTCCACCAGTGTGCTTGTCACTGTGACTGATGTCCATGACAATCCACCAAGATTTCA       GCATCACCCATATGTCACTCACATCCCATCTCCTACTCTTCCAGGTTCCTTTGTCTTTGCGGTTACAG       TCACAGATGCTGATATTGGACCAAATTCTGAACTGCATTATTCTCTTTCGGGTAGAAATTCTGAAAAA       TTTCACATTGACCCACTGAGGGGAGCCATTATGGCCGCCGGACCACTAAACGGAGCTTCAGAAGTGAC       ATTTTCTGTGCATGTAAAAGATGGTGGCTCATTTCCAAAGACAGATTCTACAACAGTGACTGTTAGAT       TCGTGAATAAGGCCGATTTCCCTAAAGTCAGAGCCAAAGAACAAACGTTCATGTTTCCTGAAAACCAA       CCAGTCAGCTCTCTTGTCACCACCATCACAGGATCCTCTTTAAGAGGAGAACCTATGTCATATTATAT       CGCAAGTGGGAATCTTGGCAATACTTTCCAGATTGATCAGTTAACAGGGCAGGTGTCTATTAGTCAAC       CTCTGGATTTTGAAAAGATACAAAAATATGTTGTATGGATAGAGGCCAGAGACGGTGGTTTCCCTCCT       TTCTCCTCTTACGAGAAACTTGATATAACAGTATTAGATGTCAATGATAATGCCCCAATTTTTAAGGA       AGACCCATTTATATCTGAAATATTGGAAAACCTTTCCCCTCGAAAAATACTTACTGTTTCGGCAATGG       ACAAGGACAGTGGACCCAATGGACAGTTAGATTATGAAATTGTTAATGGCAACATGGAAAATAGTTTC       AGTATCAATCATGCTACTGGTGAAATTAGAAGCGTTAGACCTTTGGACAGGGAAAAAGTATCTCATTA       TGTCCTAACCATAAAATCATCAGACAAAGGGTCCCCGTCTCAGAGTACTTCAGTAAAAGTCATGATTA       ACATTTTAGATGAAAATGATAATGCCCCTAGGTTTTCTCAGATATTTAGTGCCCATGTTCCTGAAAAT       TCCCCCTTAGGATACACAGTTACCCGTGTCACAACTTCTGATGAAGACATTGGGATCAATGCAATTAG       TAGATATTCTATAATGGATGCAAGTCTTCCATTTACAATTAATCCCAGCACAGGGGATATTGTCATAA       GCAGACCTTTAAATAGGGAAGATACAGACCGTTACAGAATTCGAGTTTCCGCACATGATTCTGGGTGG       ACTGTAAGTACAGATGTCACAATATTTGTGACAGACATCAATGACAATGCTCCAAGATTTAGCAGAAC       TTCCTATTATTTAGATTGCCCTGAACTTACTGAGATTGGCTCCAAAGTAACTCAGGTATTTGCAACAG       ATCCTGATGAGGGATCAAATGGACAAGTGTTTTATTTCATAAAATCCCAATCAGAATATTTCAGGATT       AATGCCACCACTGGAGAGATTTTCAATAAACAGATCTTAAAATACCAAAATGTCACTGGCTTCAGTAA       TGTGAATATCAACAGGCATAGTTTTATAGTGACATCTTCAGATCGAGGTAAACCTTCCTTAATTAGTG       AGACAACAGTTACCATCAATATAGTGGACAGTAATGACAATGCACCTCAATTTCTTAAAAGTAAATAT       TTCACTCCAGTCACCAAAAATGTTAAGGTTGGTACGAAGTTAATCAGAGTTACAGCAATAGATGACAA       AGATTTTGGACTGAATTCAGAAGTGGAGTATTTCATTTCTAATGATAACCATTTAGGAAAATTTAAGT       TGGACAATGATACGGGGTGGATTTCAGTAGCATCCTCCCTGATTTCTGACTTGAACCAAAACTTTTTT       ATCACAGTCACTGCAAAGGATAAGGGAAACCCTCCACTTTCTTCCCAAGCAACTGTTCACATAACTGT       CACTGAGGAAAACTACCATACACCTGAATTCTCTCAAAGCCACATGAGTGCAACCATCCCTGAGAGCC       ATAGCATTGGGTCCATTGTCAGAACTGTTTCTGCAAGAGATAGAGATGCAGCGATGAATGGCTTGATT       AAGTACAGCATTTCTTCAGGAAATGAAGAAGGCATTTTTGCAATCAATTCTTCTACAGGTATATTAAC       ACTAGCCAAAGCTCTTGATTATGAGCTATGCCAGAAACACGAAATGACGATTAGTGCTATAGATGGAG       GATGGGTTGCAAGAACTGGTTACTGCAGTGTGACCGTAAATGTGATTGATGTGAATGATAATTCTCCA       GTATTCCTCTCTGATGACTATTTCCCTACTGTTTTGGAAAATGCCCCAAGTGGAACAACAGTTATCCA       CCTAAATGCAACAGATGCTGACTCTGGAACAAATGCTGTGATTGCGTATACTGTACAGTCATCTGACA       GTGACCTCTTTGTCATTGACCCTAACACAGGAGTCATAACCACTCAAGGCTTCTTGGATTTTGAAACC       AAGCAGAGCTACCATCTTACTGTGAAAGCCTTCAATGTCCCCGATGAGGAAAGGTGTAGCTTTGCCAC       TGTTAATATACAATTAAAAGGGACAAATGAATATGTGCCCCGTTTTGTTTCCAAACTTTACTATTTTG       AAATCTCAGAAGCAGCTCCTAAAGGTACTATTGTTGGAGAAGTGTTTGCTAGCGACCGTGATTTGGGC       ACTGATGGGGAGGTACACTATTTGATTTTTGGTAATAGTCGAAAGAAGGGTTTCCAGATCAATAAGAA       GACTGGACAGATTTATGTTTCTGGAATTCTTGATCGAAAAAAAGAAGAAAGGGTGTCTTTGAAGGTAT       TGGCCAAGAACTTTGGCAGCATTAGAGGTGCAGATATAGATGAGGTCACTGTAAATGTCACCGTGCTT       GATGCAAATGACCCACCCATTTTTACTCTAAACATCTACAGTGTGCAGATCAGTGAAGGGGTCCCAAT       AGGAACTCATGTGACCTTTGTCAGTGCCTTTGACTCAGACTCCATCCCCAGCTGGAGCAGGTTTTCTT       ACTTCATCGGATCAGGGAATGAAAATGGTGCCTTTTCTATTAATCCGCAGACAGGACAGATCACCGTT       ACTGCAGAATTAGATCGAGAAACCCTTCCCATCTATAATCTCTCAGTTTTGGCTGTTGATTCAGGGAC       CCCCTCAGCTACAGGTAGTGCCTCTTTATTAGTCACCCTGGAAGATATAAATGATAACGGGCCCATGC       TGACTGTCAGTGAAGGAGAAGTCATGGAAAACAAACGGCCAGGCACTTTGGTGATGACCCTTCAGTCC       ACTGACCCTGATCTCCCTCCAAATCAAGGTCCCTTTACTTATTACTTGCTGAGCACAGGTCCTGCCAC       CAGTTATTTCAGTCTGAGCACTGCTGGAGTTCTGAGCACAACCAGAGAGATTGACAGAGAGCAGATTG       CAGACTTCTATCTGTCTGTGGTTACCAAGGATTCTGGTGTTCCTCAAATGTCTTCCACAGGAACTGTG       CATATCACAGTTATAGACCAAAATGACAATCCTTCACAGTCTCGGACGGTGGAGATATTTGTTAATTA       TTATGGTAACTTGTTTCCCGGTGGGATTTTAGGCTCTGTGAAGCCACAGGATCCAGATGTGTTAGACA       GCTTCCACTGCTCCCTTACTTCAGGAGTTACCAGCCTCTTCAGTATTCCAGGGGGTACTTGTGATCTG       AATTCCCAGCCAAGGTCCACAGATGGCACGTTTGATCTGACTGTCCTTAGCAATGATGGAGTTCACAG       CACAGTCACGAGCAACATCCGAGTTTTCTTTGCTGGATTTTCCAATGCCACAGTGGATAACAGCATCT       TACTTCGTCTCGGCGTACCAACAGTAAAGGACTTCTTGACCAACCACTATCTTCATTTTTTACGCATT       GCCAGCTCACAGCTGACAGGCTTAGGGACTGCTGTGCAACTGTACAGTGCATATGAAGAGAACAATAG       AACGTTTCTTTTGGCAGCTGTGAAGCGAAATCATAATCAGTATGTGAATCCCAGTGGCGTAGCCACCT       TCTTTGAAAGCATCAAAGAGATCCTTCTCCGGCAGAGTGGAGTAAAGGTGGAATCTGTGGATCATGAC       TCCTGTGTGCATGGCCCATGTCAGAATGGAGGGAGCTGTCTACGAAGATTGGCTGTGAGCTCCGTATT       AAAAAGCCGTGAGAGTCTTCCAGTCATCATCGTGGCAAATGAACCTCTGCAGCCTTTCTTATGCAAGT       GTCTGCCAGGATATGCGGGTAGCTGGTGTGAAATAGATATAGATGAATGTCTTCCATCACCTTGCCAC       AGTGGTGGAACCTGTCACAATTTAGTGGGAGGATTTTCATGCAGCTGCCCAGATGGCTTCACTGGTAG       GGCGTGTGAGAGAGATATCAATGAGTGCCTGCAGAGTCCTTGCAAGAATGGTGCCATCTGCCAGAATT       TTCCAGGAAGCTTCAACTGTGTTTGCAAAACTGGATACACAGGTATGACAACGTTTGTACTTTTCTCA       CTAAGACTTGGAAAATGTGTGAATCTTCAGTCAATTACTGTGAATGCAACCCCTGCTTTAATGGTGGT       TCCTGCCAAAGTGGTGTGGATTCTTATTATTGTCATTGTCCATTTGGTGTCTTTGGAACACTGCGAGT       TGAACAGTTATGGATTTGAGGAGTTATCATACATGGAATTTCCAAGCTTGGACCCCAATAACAACTAT       ATTTATGTCAAATTTGCCACGATTAAAAGTCATGCCTTATTGCTTTACAACTATGACAACCAGACAGG       CGACCGGGCTGAGTTTTTGGCCCTTGAAATTGCCGAAGAAAGACTAAGATTCTCTTATAATTTAGGCA       GTGGTACATATAAGCTCACCACCATGAAGAAGGTGTCAGATGGACATTTTCACACTGTGATTGCCAGG       AGAGCAGGAATGGCAGCCTCCTTAACTGTGGACTCCTGTTCTGAGAACCAAGAGCCAGGATATTGTAC       TGTCAGTAATGTGGCAGTTTCAGATGACTGGACTCTTGATGTTCAGCCAAATAGAGTTACAGTTGGAG       GTATCAGATCTCTAGAACCAATCCTTCAGAGAAGAGGACACGTGGAAAGCCATGATTTTGTTGGGTGT       ATAATGGAGTTTGCAGTCAATGGAAGGCCTCTGGAACCCAGCCAAGCTTTGGCAGCACAAGGCATCCT       AGATCAGTATGGCGATTTTATTTCTTACTGTTTTAAAGAAAAAAAATGCAAAAAAGTATGCTTCACTG       TTACTCCTGACACTGCCTTATCATTAGAAGGCAAAGGGCGCTTGGACTACCACATGAGTCAGAATGAG       AAGCGGGAATATTTGTTAAGGCAAAGCTTACGAGGTGCCATGTTGGAGCCTTTTGGTGTGAACAGTCT       GGAAGTAAAATTTAGGACCAGAAGCGAGAATGGCGTTTTAATCCATATCCAAGAAAGCAGCAATTACA       CTACTGTGAAGGGAATGTGTGAATCTTCAGTCAATTACTGTGAATGCAACCCCTGCTTTAATGGTGGT       TCCTGCCAAAGTGGTGTGGATTCTTATTATTGTCATTGTCCATTTGGTGTCTTTGGAAAACACTGCGA       GTTGAACAGTTATGGATTTGAGGAGTTATCATACATGGAATTTCCAAGCTTGGACCCCAATAACAACT       ATATTTATGTCAAATTTGCCACGATTAAAAGTCATGCCTTATTGCTTTACAACTATGACAACCAGACA       GGCGACCGGGCTGAGTTTTTGGCCCTTGAAATTGCCGAAGAAAGACTAAGATTCTCTTATAATTTAGG       CAGTGGTACATATAAGCTCACCACCATGAAGAAGGTGTCAGATGGACATTTTCACACTGTGATTGCCA       GGAGAGCAGGAATGACTCTTGATGTTCAGCCAAATAGAGTTACAGTTGGAGGTATCAGATCTCTAGAA       CCAATCCTTCAGAGAAGAGGACACGTGGAAAGCCATGATTTTGTTGGGTGTATAATGGAGTTTGCAGT       CAATGGAAGGCCTCTGGAACCCAGCCAAGCTTTGGCAGCACAAGGCATCCTAGATCAGTATGGCGATT       TTATTTCTTACTGTTTTAAAGAAAAAAAATGCAAAAAGTATGCTTCACTTGGCCTCCATCTCGGGAAG       CATAGCTTGGCCTCCATCTCAAAAACAGATCCCTCAGTGAAGATTGGCTGCCGTGGCCCGAACATTTG       TGCCAGCAACCCCTGCTGGGGTGATTTGCTGTGCATTAATCAGTGGTATGCCTACAGGTGTGTCCCTC       CTGGGGACTGTGCCTCCCACCCGTGCCAGAATGGTGGCAGCTGTGAGCCAGGCCTGCACTCCGGCTTC       ACCTGTAGCTGCCCAGACTCGCACACGGGAAGGACCTGTGAGATGGTGGTGGCCTGTCTTGGCGTCCT       CTGTCCTCAGGGGAAGGTGTGCAAAGCTGGAAGTCCTGCGGGGCATGTCTGTGTTCTGAGTCAGGGCC       CTGAAGAGATCTCTCTGCCTTTGTGGGCTGTGCCTGCCATCGTGGGCAGCTGCGCAACCGTCTTGGCC       CTCCTGGTCCTTAGCCTGATCCTGTGTAACCAGTGCAGGGGGAAGAAGGCCAAAAATCCCAAAGAGGA       GAAGAAACCGAAGGAGAAGAAGAAAAAGGGAAGTGAGAACGTTGCTTTTGATGACCCTGACAATATCC       CTCCCTATGGGGATGACATGACTGTGAGGAAGCAGCCTGAAGGGAACCCAAAACCAGATATCATTGAA       AGGGAAAACCCCTACCTTATCTATGATGAAACTGATATTCCTCACAACTCAGAAACCATCCCCAGCGC       CCCTTTGGCATCTCCAGAGCAGGAGATAGAGCACTATGACATTGACAACGCCAGCAGCATCGCCCCTT       CGGATGCAGACATCATTCAACACTACAAGCAGTTCCGCAGCCACACACCAAAATTTTCAATCCAGAGG       CACAGTCCCCTAGGCTTTGCAAGGCAATCCCCCATGCCCTTAGGAGCAAGCAGTTTGACTTACCAGCC       TTCATATGGTCAAGGTTTGAGAACCAGCTCCCTAAGCCACTCAGCATGCCCAACTCCCAACCCTCTGT       CTCGACACAGTCCAGCCCCTTTCTCCAAATCTTCTACGTTCTATAGAAACAGCCCAGCAAGGGAATTG       CATCTTCCTATAAGGGATGGTAATACTTTGGAAATGCATGGTGACACCTGCCAACCTGGCATTTTCAA       CTATGCCACAAGGCTGGGAAGGAGAAGCAAGAGTCCTCAGGCCATGGCATCACATGGTTCTAGACCAG       GGAGTCGCCTAAAGCAGCCGATTGGGCAGATTCCACTGGAATCTTCTCCTCCAGTCGGACTTTCTATT       GAAGAAGTGGAGAGGCTCAACACACCTCGCCCTAGAAACCCAAGTATCTGCAGTGCAGACCATGGGAG       GTCTTCTTCAGAGGAGGACTGCAGAAGGCCACTGTCTAGAACAAGGAATCCAGCGGATGGCATTCCAG       CTCCAGAATCCTCTTCTGATAGTGACTCCCATGAATCTTTCACTTGCTCAGAAATGGAATATGACAGG       GAGAAGCCAATGGTATATACTTCCAGAATGCCCAAATTATCTCAAGTCAATGAATCTGATGCAGATGA       TGAAGATAATTATGGAGCCAGACTGAAGCCTCGAAGGTACCACGGTCGCAGGGCCGAGGGAGGACCTG       TGGGCACCCAGGCAGCAGCACCAGGCACTGCTGACAACACACTGCCCATGAAGCTAGGGCAGCAAGCA       GGGACTTTCAACTGGGACAACCTTTTGAACTGGGGCCCTGGCTTTGGCCATTATGTAGATGTTTTTAA       AGATTTGGCATCTCTTCCAGAAAAAGCAGCAGCAAATGAAGAAGGCAAAGCTGGGACAACTAAACCAG       TCCCCAAAGATGGGGAAGCAGAACAGTATGTG TGA   AGTTTATGTACTGGCACTATAAAATATAAAAAC           AAGAAATAATACTCAAACCATTGTAAAGTTGCTGACTAGGTTGGGTCACATTTGAAAAACAGGCCAGT           ATGGACTAGTGGTGGAGGGAAAACTTTAAAAATAATAACCACAATGCTGCTGAAACAGACTCACAACA           ACTCTTAATTTAAACATGTGTGGTTGAATTC                                                   NOV57a, CG92813-01   SEQ ID NO: 1132   4961 aa   MW at 543673.9kD               Protein Sequence                     MDLAPDRATGRPWLPLHTLSVSQLLRVFWLLSLLPGQAWVHGAEPRQVFQVLEEQPPGTLVGTIQTRP           GFTYRLSESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVFP       DPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDINLNPSGEGAFLHLVS       KGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQV       AAADADEGTNADIRYRLQDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEAL       IQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFE       VQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFS       QQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDREL       ASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDL       GDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLL       DINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGDRSRFQVNAQSGVISTR       MALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVS       ASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTVTGDTMVNITVK       DLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAINEKNGTISLL       GPLDVHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQA       SDKDSGANDGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFY       FEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFS       FTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGL       IHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNT       PSFLKSTLFVDVLENMRIGELVSSVTATDSDSGDNVDLYYSITGTNNHGTFSISPNTGSIFLAKKLDF       ETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPD       ADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVT       ILVTDLNDNVPMFISQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDTFIVDRYSGDL       RVASALVPSQLIYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGTNVISIE       AASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPR       TQRAEVETTLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEVQMLSSHTLSLVGSLVAAI       LATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVY       FNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADMMKAEIKMFFETSENKDTTYQNLWDTF       KAVCRGKFIALNAHKRKQERSKIDTLTSQLKELEKQEQTHSKASRRQEITKIRAELKDIETQKTLQKI       NESRSWFFERINKIDRPLARLIKKKTEKNQIDAIKNDKGDITIDPTEIQTTIREYCKHLYANKLENLE       EMDKFLDTYTLPRLNQEEVESLNRPITDSETVATINSLPTKKSPGPDGFTAEFYQMITTPVFAQALYK       VEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLT       VQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQTASPCVRFASASKAY       FTTIPEDAPTGTDVLLVNASDADASKNAVISYRIIGGNSQFTINPSTGQIITSALLDRETKDNYTLVV       VCSDAGSPEPLSSSTSVLVTVTDVHDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHY       SLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFSVHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAKE       QTFMFPENQPVSSLVTTTTGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWI       EARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKILTVSAMDKDSGPNGQLDYEI       VNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQ       IFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLPFTINPSTGDIVISRPLNPEDTDRYRI       RVSAHDSGWTVSTDVTIFVTDTNDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFI       KSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDN       APQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSL          
 
      Further analysis of the NOV57a protein yielded the following properties shown in Table 57C.  
               TABLE 57C                       Protein Sequence Properties NOV57a                                        SignalP analysis:   Cleavage site between residues 43 and 44       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 11; pos. chg 2; neg. chg 2           H-region:   length 14; peak value 5.01           PSG score:   0.61                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −0.05           possible cleavage site: between 42 and 43                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 42)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 43           Tentative number of TMS(s) for the threshold 0.5: 4                                 INTEGRAL   Likelihood =   Transmembrane 1753-1769                −0.59           INTEGRAL   Likelihood =   Transmembrane 2193-2209                0.26           INTEGRAL   Likelihood =   Transmembrane 3837-3853               −11.25           INTEGRAL   Likelihood =   Transmembrane 4488-4504                −9.08                             PERIPHERAL   Likelihood =  1.38 (at 1566)                         ALOM score: −11.25 (number of TMSs: 4)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 21           Charge difference: −0.5 C(1.0)-N(1.5)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 3a                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:    0   Hyd Moment(75):   8.27           Hyd Moment(95):   10.66   G content:   0           D/E content:    2   S/T content:   0                         Score: −6.21       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: PKRR (4) at 228           pat4: HKRK (3) at 1918           pat4: KKPK (4) at 4521           pat4: KKKK (5) at 4526           pat4: KPRR (4) at 4869           pat7: PKRRGYL (5) at 228           pat7: PERRKST (5) at 1588           pat7: PKEKKKK (5) at 4523           bipartite: KKTGQIYVSGILDRKKE at 3227           bipartite: KKAKNPKEEKKPKEKKK at 4512           content of basic residues: 8.4%           NLS Score: 3.22       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: found       KIDTLTSQL at 1926       VAC: possible vacuolar targeting motif: found       TLPI at 3349       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 55.5       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions       1912 I   0.91       1913 A   0.91       1914 L   0.91       1915 N   0.91       1916 A   0.97       1917 H   0.98       1918 K   1.00       1919 R   1.00       1920 K   1.00       1921 Q   1.00       1922 E   1.00       1923 R   1.00       1924 S   1.00       1925 K   1.00       1926 I   1.00       1927 D   1.00       1928 T   1.00       1929 L   1.00       1930 T   1.00       1931 S   1.00       1932 Q   1.00       1933 L   1.00       1934 K   1.00       1935 E   1.00       1936 L   1.00       1937 E   1.00       1938 K   1.00       1939 Q   1.00       1940 E   1.00       1941 Q   1.00       1942 T   1.00       1943 H   1.00       1944 S   1.00       1945 K   1.00       1946 A   0.98       1947 S   0.97       1948 R   0.96       1949 R   0.96       1950 Q   0.96       1951 E   0.96       1952 I   0.92       1953 T   0.73       1954 K   0.59           total: 43 residues                 Final Results (k = 9/23):                         47.8%: endoplasmic reticulum           21.7%: nuclear           13.0%: mitochondrial            4.3%: vacuolar            4.3%: Golgi            4.3%: plasma membrane            4.3%: vesicles of secretory system                 &gt;&gt; prediction for CG92813-01 is end (k = 23)                  
 
      A search of the NOV57a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 57D.  
               TABLE 57D                          Geneseq Results for NOV57a                                         NOV57a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value                                             ABU12072   Human NOV17a CG92813-01 protein    1 . . . 4961   4892/4961   (98%)   0.0           SEQ ID 64 -  Homo sapiens , 4903 aa.    1 . . . 4903   4896/4961   (98%)           [WO200281625-A2, 17-OCT-2002]       ABB59831     Drosophila melanogaster  polypeptide   49 . . . 1878   748/1932   (38%)   0.0           SEQ ID NO 6285 -  Drosophila     71 . . . 1951   1066/1932   (54%)             melanogaster , 5147 aa.           [WO200171042-A2, 27-SEP-2001]       AAO26789   Human cadherin (CAD) protein, SEQ   364 . . . 3239    839/3033   (27%)   0.0           ID No 12 -  Homo sapiens , 3354 aa.   39 . . . 2911   1324/3033   (42%)           [WO200299042-A2, 12-DEC-2002]       AAO26793   Human cadherin (CAD) protein, SEQ    5 . . . 1877   621/1950   (31%)   0.0           ID No 16 -  Homo sapiens , 3298 aa.   12 . . . 1883   925/1950   (46%)           [WO200299042-A2, 12-DEC-2002]       ABB05430   Human dachsous protein SEQ ID    5 . . . 1877   621/1950   (31%)   0.0           NO: 2 -  Homo sapiens , 3298 aa.   12 . . . 1883   925/1950   (46%)           [JP2001327295-A, 27-NOV-2001]                  
 
      In a BLAST search of public sequence databases, the NOV57a protein was found to have homology to the proteins shown in the BLASTP data in Table 57E.  
               TABLE 57E                          Public BLASTP Results for NOV57a                                         NOV57a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             P33450   Cadherin-related tumor suppressor   49 . . . 1878   748/1932   (38%)   0.0           precursor (Fat protein) -  Drosophila     71 . . . 1951   1066/1932   (54%)             melanogaster  (Fruit fly), 5147 aa.       IJFFTM   cadherin-related tumor suppressor   49 . . . 1878   744/1932   (38%)   0.0           precursor - fruit fly ( Drosophila     71 . . . 1951   1065/1932   (54%)             melanogaster ), 5147 aa.       Q8CD68   Hypothetical ATP/GTP-binding site   4515 . . . 4961    422/448   (94%)   0.0           motif A -  Mus musculus  (Mouse),   3 . . . 448   430/448   (95%)           448 aa.       Q96JQ0   Protocadherin 16 precursor    5 . . . 1877   621/1950   (31%)   0.0           (Cadherin 19) (Cadherin fibroblast   12 . . . 1883   925/1950   (46%)           1) -  Homo sapiens  (Human), 3298           aa.       Q8BM82   Hypothetical cadherin domain   1384 . . . 1900    393/518   (75%)   0.0           containing protein -  Mus musculus     1 . . . 490   420/518   (80%)           (Mouse), 575 aa.                  
 
      PFam analysis predicts that the NOV57a protein contains the domains shown in the Table 57F.  
               TABLE 57F                          Domain Analysis of NOV57a                                     Identities/           Pfam   NOV57a   Similarities for   Expect       Domain   Match Region   the Matched Region   Value                                         cadherin    47 . . . 126   19/107   (18%)   0.018               59/107   (55%)       cadherin   140 . . . 241   35/113   (31%)   6.6e−15               77/113   (68%)       cadherin   255 . . . 344   42/107   (39%)   4.5e−28               75/107   (70%)       cadherin   363 . . . 466   44/113   (39%)   3.2e−23               79/113   (70%)       cadherin   480 . . . 573   37/109   (34%)     9e−25               75/109   (69%)       cadherin   588 . . . 680   46/108   (43%)   1.2e−26               76/108   (70%)       cadherin   694 . . . 784   43/107   (40%)   1.5e−26               68/107   (64%)       cadherin   798 . . . 884   33/107   (31%)   5.7e−18               66/107   (62%)       cadherin   898 . . . 987   32/107   (30%)   7.5e−18               65/107   (61%)       cadherin   1001 . . . 1071   24/107   (22%)   1.2e−08               58/107   (54%)       cadherin   1085 . . . 1181   34/111   (31%)   7.6e−14               71/111   (64%)       cadherin   1195 . . . 1286   39/107   (36%)     5e−27               76/107   (71%)       cadherin   1300 . . . 1391   42/107   (39%)     5e−27               71/107   (66%)       cadherin   1405 . . . 1500   38/108   (35%)   6.1e−19               73/108   (68%)       cadherin   1506 . . . 1602   30/114   (26%)   2.3e−12               71/114   (62%)       cadherin   1614 . . . 1711   28/112   (25%)    0.0069               63/112   (56%)       cadherin   1754 . . . 1840   31/107   (29%)   2.4e−13               64/107   (60%)       cadherin   2107 . . . 2198   44/107   (41%)   4.7e−31               76/107   (71%)       cadherin   2244 . . . 2334   45/107   (42%)   2.6e−28               73/107   (68%)       cadherin   2348 . . . 2436   33/107   (31%)   2.8e−12               66/107   (62%)       cadherin   2449 . . . 2537   37/107   (35%)     4e−11               67/107   (63%)       cadherin   2551 . . . 2641   36/107   (34%)   1.2e−25               72/107   (67%)       cadherin   2654 . . . 2740   38/107   (36%)   2.7e−17               64/107   (60%)       cadherin   2754 . . . 2851   32/116   (28%)     4e−16               75/116   (65%)       cadherin   2865 . . . 2957   41/107   (38%)   1.26-15               68/107   (64%)       cadherin   2971 . . . 3062   36/107   (34%)   3.2e−26               75/107   (70%)       cadherin   3076 . . . 3164   36/108   (33%)   2.9e−21               67/108   (62%)       cadherin   3180 . . . 3273   33/107   (31%)   1.7e−16               71/107   (66%)       cadherin   3286 . . . 3378   37/107   (35%)   4.2e−28               79/107   (74%)       cadherin   3390 . . . 3482   38/109   (35%)   7.7e−22               76/109   (70%)       EGF   3743 . . . 3774   18/47   (38%)   2.2e−08               25/47   (53%)       EGF   3781 . . . 3812   15/47   (32%)   9.2e−05               25/47   (53%)       laminin_G   3890 . . . 4033   49/158   (31%)   6.4e−16               101/158   (64%)       EGF   4148 . . . 4179   16/47   (34%)   0.014               24/47   (51%)       laminin_G   4208 . . . 4322   46/156   (29%)     9e−05               85/156   (54%)       EGF   4410 . . . 4442   16/47   (34%)   3.1e−06               26/47   (55%)                  
 
     Example 58  
      The NOV58 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 58A.  
               TABLE 58A                       NOV58 Sequence Analysis                                                NOV58a, CG93387-05   SEQ ID NO:1143   5432 bp           DNA Sequence   ORF Start: ATG at 187   ORF Stop: TAA at 3991                       GGTGCCGAGCACTCCGGACTCTACGTGAACAACAACGGGATCATCTCCTTCCTGAAGGAGGTTTCTCA               GTTCACCCCAGTGGCCTTCCCCATTGCCAAGGACCGCTGCGTGGTGGCAGCCTTCTGGGCAGATGTGG           ACAACCGGCGTGCAGGCGACGTGTACTACCGGGAGGCCACCGACCCAGCC   ATG CTGCGCCGAGCCACG       GAGGACGTCAGGCACTACTTCCCCGAGCTCCTGGACTTCAATGCCACCTGGGTTTTTGTTGCCACCTG       GTACCGAGTGACCTTCTTTGGAGGCAGTTCCTCATCCCCTGTCAACACATTCCAGACTGTGCTCATCA       CAGACGGCAAGCTCTCCTTCACCATCTTCAACTATGAGTCCATCGTGTGGACCACAGGCACACACGCC       AGCAGCGGGGGCAACGCCACTGGCCTCGGGGGCATCGCAGCCCAGGCTGGCTTCAACGCAGGCGATGG       GCAGCGTTACTTCAGTATCCCCGGCTCGCGCACAGCAGACATGGCCGAGGTGGAGACCACCACCAACG       TGGGTGTGCCCGGGCGCTGGGCGTTCAGAATCGATGATGCCCAGGTGCGCGTGGGGGGCTGCGGCCAT       ACAACGTCCGTGTGCCTGGCCCTGCGCCCCTGCCTCAACGGCGGCAAGTGCATCGACGACTGCGTCAC       GGGCAACCCCTCCTACACCTGCTCCTGCCTCTCGGGCTTCACGGGGCGGAGGTGCCACCTGGACGTGA       ACGAATGTGCCTCCCAGCCCTGTCAGAATGGTGGGACCTGTACTCACGGCATCAACAGTTTCCGCTGC       CAGTGCCCGGCTGGCTTTGGGGGACCCACCTGTGAGACAGCCCAATCCCCCTGTGACACCAAAGAGTG       TCAACATGGTGGCCAGTGCCAGGTGGAGAACGGCTCTGCGGTGTGTGTGTGCCAGGCCGGATACACCG       GAGCAGCCTGCGAGATGGATGTGGACGACTGCAGCCCTGACCCCTGCCTGAATGGAGGCTCTTGTGTT       GACCTAGTGGGGAATTACACCTGCTTGTGTGCCGAGCCCTTCAAGGGACTTCGCTGTGAGACAGGAGA       CCATCCAGTGCCAGACGCCTGCCTCTCGGCCCCTTGCCACAATGGGGGCACCTGTGTGGATGCGGACC       AGGGCTACGTGTGCGAGTGCCCCGAAGGCTTCATGGGCCTGGACTGCAGGGAGAGAGTCCCCGATGAC       TGTGAGTGCCGCAACGGAGGCAGATGCCTGGGCGCCAACACCACCCTCTGCCAGTGCCCCCTGGGATT       CTTTGGGCTTCTCTGTGAATTTGAAATCACAGCCATGCCCTGCAACATGAACACACAGTGCCCAGATG       GGGGCTACTGCATGGAGCACGGCGGGAGCTACCTCTGCGTCTGCCACACCGACCACAATGCCAGCCAC       TCCCTGCCATCACCCTGCGACTCGGACCCCTGCTTCAACGGAGGCTCCTGCGATGCCCATGACGACTC       CTACACCTGCGAGTGCCCGCGCGGGTTCCACGGCAAGCACTGCGAGAAAGCCCGGCCACACCTGTGCA       GCTCAGGGCCCTGCCGGAACGGGGGCACGTGCAAGGAGGCGGGCGGCGAGTACCACTGCAGCTGCCCC       TACCGCTTCACTGGGAGGCACTGTGAGATCGGGAAGCCAGACTCGTGTGCCTCTGGCCCCTGTCACAA       CGGCGGCACCTGCTTCCACTACATTGGCAAATACAAGTGTGACTGTCCCCCAGGCTTCTCCGGGCGGC       ACTGCGAGATAGCCCCCTCCCCCTGCTTCCGGAGCCCGTGTGTGAATGGGGGCACCTGCGAGGACCGG       GACACGGATTTCTTCTGCCACTGCCAAGCAGGGTACATGGGACGCCGGTGCCAGGCAGAGGTGGACTG       CGGCCCCCCGGAGGAGGTGAAGCACGCCACACTGCGCTTCAACGGCACGCGGCTGGGCGCGGTGGCCC       TGTATGCATGTGACCGTGGCTACAGCCTGAGCGCCCCCAGCCGCATCCGGGTCTGCCAGCCACACGGT       GTCTGGAGTGAGCCTCCCCAGTGCCTTGAAATCGATGAGTGCCGGTCTCAGCCGTGCCTGCATGGGGG       CTCTTGTCAGGACCGCGTTGCTGGGTACCTGTGCCTCTGCAGCACAGGCTATGAGGGCGCCCACTGTG       AGCTGGAGAGGGATGAGTGCCGAGCTCACCCGTGCAGAAATGGAGGGTCCTGCAGGAACCTCCCAGGG       GCCTATGTCTGCCGGTGCCCTGCAGGCTTCGTTGGAGTCCACTGTGAGACAGAGGTGGACGCCTGCGA       CTCCAGCCCCTGCCAGCATGGAGGCCGGTGTGAGAGCGGCGGCGGGGCCTACCTGTGCGTCTGCCCAG       AGAGCTTCTTCGGCTACCACTGCGAGACAGTGAGTGACCCCTGCTTCTCCAGCCCCTGTGGGGGCCGT       GGCTATTGCCTGGCCAGCAACGGCTCCCACAGCTGCACCTGCAAAGTGGGCTACACGGGCGAGGACTG       CGCCAAAGAGCTCTTCCCACCGACGGCCCTCAAGATGGAGAGAGTGGAGGAGAGTGGGGTCTCTATCT       CCTGGAACCCGCCCAATGGTCCAGCCGCCAGGCAGATGCTTGATGGCTACGCGGTCACCTACGTCTCC       TCCGACGGCTCCTACCGCCGCACAGACTTTGTGGACAGGACCCGCTCCTCGCACCAGCTCCAGGCCCT       GGCGGCCGGCAGGGCCTACAACATCTCCGTCTTCTCAGTGAAGCGAAACAGTAACAACAAGAATGACA       TCAGCAGGCCTGCCGTGCTGCTGGCCCGCACGCGACCCCGCCCTGTGGAAGGCTTCGAGGTCACCAAT       GTGACGGCTAGCACCATCTCAGTGCAGTGGGCCCTGCACAGGATCCGCCATGCCACCGTCAGTGGGGT       CCGTGTGTCCATCCGCCACCCTGAGGCCCTCAGGGACCAGGCCACCGATGTGGACAGGAGTGTGGACA       GGTTCACCTTTAGGGCCCTGCTGCCTGGGAAGAGGTACACCATCCAGCTGACCACCCTCAGTGGGCTC       AGGGGAGAGGAGCACCCCACAGAGAGCCTGGCCACCGCGCCGACGCACGTGTGGACCCGGCCCCTGCC       CAGGCAGCTTGCTGGAGGCTTATGTCATCAATGTGACCACCAGCCAGAGCACCAAGAGCCGCTATGTC       CCCAACGGGAAGCTGGCGTCCTACACGGTGCGCGACCTGCTGCCGGGACGGCGGTACCAGCCCTCTGT       GATAGCAGTGCAGAGCACGGAGCTCGGGCCGCAGCAGCACCAGGGAGGACACCACCCTCGGGTGCTCA       AGAACAGACCGCCCCCGGCGCGCCTGCCGGAGCTGCGCCTGCTCAATGACCACAGCGCCCCCGAGACC       CCCACCCAGCCCCCCAGGTTCTCGGAGTTTGTGGACGGCAGAGGAAGAGTGAGCGCCAGGTTCGGTGG       CTCACCCAGCAAAGCAGCCACCGTGAGATCACAACCCACAGCCTCGGCGCAGCTCGAGAACATGGAGG       AAGCCCCCAAGCGGGTCAGCCCGGCCCTCCAGCTCCCTGAACACGGCAGCAAGGACATCGGAAACGTC       CCTGGCAACTGTTCAGAAAACCCCTGTCAGAACGGAGGCACTTGTGTGCCGGGCGCAGACGCCCACAG       CTGTGACTGCGGGCCAGGGTTCAAAGGCAGACGCTGCGAGCTCGCCTGTATAAAGGTGTCCCGCCCCT       GCACAAGGCTGTTCTCCGAGACAAAGGCCTTTCCAGTCTGGGAGGGAGGCGTCTGTCACCACGTGTAT       AAAAGAGTCTACCGAGTTCACCAAGACATCTGCTTCAAAGAGAGCTGTGAAAGCACAAGCCTCAAGAA       GACCCCAAACAGGAAACAAAGTAAGAGTCAGACACTGGAGAAATCT TAA   GGATTTAAGACGTTCTTGT           TACACTCCACCAACCTCACGAGTTTCTAACACCCAGGAAGATGAGGTCTAAAAACTGGATGAAAAAGG           ACACCCTGAGAAAAGGTCCTAGCTGGAGTCAGTCCCCTCTGTGACCTCTCTCCTCAGGCCTCTAGAGG           ACAGATGGCCAGGCCTGTGCACACACCAGCCCACCCTGAGAGACCCCTCTGGGACCAACCACCTGTGA           GTCCTGCGATGCGTTTAAGCAGCCTGTGCCCTCACCCAAGCTGCAGTTCCTGAAGGTGTAGTCTGTGT           CTCTGCGGATGAGATGACAGCTCGCCATTCCCCGGAATCAGTGAGGCTGTCAGTCAGCCACGCTTCTG           CAGTATGCAGAAACCTGTTCTTAGACTCCAAAGCCAGAGAAAGAATTCTCCCTTCGAGGCCCAACAAA           TTGAGAAGGAACTGTGATGGACCACTTCCAAAACAGAGACGGGGGCAGGGGCTGAAGGGCAGAGACCA           GGTGATGTCAGAAGGAAAGCCGGGTTGCAGACACAGCCGCCCCTGCTCTGGTCCTCCAGCGTGTTTAT           GACGCTCGTGCAGGTCGACGAGCCATCCTATGGACTAGTTAACACTAAGGTGGAGTTCAGACTTTTTT           AGACAACGGCGCGACTGGCAGCCTTTCTCTATCAAGGGTCAGACGGTAAACGTTTTCAGCTTTGCAGA           CCAGAGGTCCCTGTGGCTACAGTAGCGCAGACACAGCCACAGGCATGTCATTGAATGGCTGCGGCTAT           GTTCCAATAAAAACTTATTTACAATAACAGGTGGTGGCCAAATTGGCCCATGGGCCTTATTTGGTGAA           CCCTGTTCTATGAGATCACCTAGGCTTCAGCCTTAAACAGTGGAAGCCATCCCCTGAATGACAAGTCA           CAAGGGTATCAAAGAAAGACCCCTGAATTTTCATGGAAAAAGCTATTCAGACCCCTGCTTGGAAAGCT           AAGGCACACTGCCACGAAGCAGCAAGGACGCCTTACAAGTCTCAGTGCAACAGAGATGGACACCTGGG           CTGGGCTGGACAATGTTTAAGGTTCCTTTTAGTCCATGACTCAAGTGATACTGTTTTAGGCTATCAGC           TAGTAAACACGATCTTAGACATCCCCATCTTTGTAAGCAGAACAGTACGGCACTTCACCACATCTGCT           TCCCACCATGCTTCTAAGCAGCTGTCTTCCCCCTGCTAATGTTACAACCAAAGCAGCCACCCCACCTC           CTCTCGTGTTGAGCCTCACGACCGCTGACCCAGCTGGAAAGCCAGCGCCCTGCCGCGTCACCCTGACT           CTGCTCAGAGCCAGCATTCCAGCCACAAAGAGGGCCTCCTTCCTTTCCTCTTTCATAAAAATGTTTTT           TGAAGAGTTAGAGTATATTTTAGGCTTTTTATCTTTATTAAAATTTCATGTGCATGTGTA                                           NOV58a, CG93387-05   SEQ ID NO:1144   1268 aa   MW at 136576.5 kD           Protein Sequence                     MLRRATEDVRHYFPELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGKLSFTIFNYESIVW           TTGTHASSGGNATGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTNVGVPGRWAFRIDDAQVR       VGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHG       INSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPCL       NGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCR       ERVPDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHT       DHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGE       YHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNG       GTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIR       VCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGS       CRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFS       SPCGGRGYCLASNGSHSCTCKVGYTGEDCAKELFPPTALKNERVEESGVSISWNPPNGPAARQMLDGY       AVTYVSSDGSYRRTDFVDRTRSSHQLQALAAGRAYNISVFSVKRNSNNKNDISRPAVLLARTRPRPVE       GFEVTNVTASTISVQWALHRIRHATVSGVRVSIRHPEALRDQATDVDRSVDRFTFRALLPGKRYTIQL       TTLSGLRGEEHPTESLATAPTHVWTRPLPPANLTAARVTATSAHVVWDAPTPGSLLEAYVINVTTSQS       TKSRYVPNGKLASYTVRDLLPGRRYQPSVIAVQSTELGPQQHQGGHHPRVLKNRPPPARLPELRLLND       HSAPETPTQPPRFSEFVDGRGRVSARFGGSPSKAATVRSQPTASAQLENNEEAPKRVSPALQLPEHGS       KDIGNVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGG       VCHHVYKRVYRVHQDICFKESCESTSLKKTPNRKQSKSQTLEKS                                     NOV58b, CG93387-01   SEQ ID NO:1145   4401 bp           DNA Sequence   ORF Start: ATG at 187   ORF Stop: TAA at 4051                       GGTGCCGAGCACTCCGGACTCTACGTGAACAACAACGGGATCATCTCCTTCCTGAAGGAGGTTTCTCA               GTTCACCCCAGTGGCCTTCCCCATTGCCAAGGACCGCTGCGTGGTGGCAGCCTTCTGGGCAGATGTGC           ACAACCGGCGTGCAGGCGACGTGTACTACCGGGAGGCCACCGACCCAGCC   ATG CTGCGCCGAGCCACG       GAGGACGTCAGGCACTACTTCCCCGAGCTCCTGGACTTCAATGCCACCTGGGTTTTTGTTGCCACCTG       GTACCGAGTGACCTTCTTTGGAGGCAGTTCCTCATCCCCTGTCAACACATTCCAGACTGTGCTCATCA       CAGACGGCAAGCTCTCCTTCACCATCTTCAACTATGAGTCCATCGTGTGGACCACAGGCACACACGCC       AGCAGCGGGGGCAACGCCACTGGCCTCGGGGGCATCGCAGCCCAGGCTGGCTTCAACGCAGGCGATGG       GCAGCGTTACTTCAGTATCCCCGGCTCGCGCACAGCAGACATGGCCGAGGTGGAGACCACCACCAACG       TGGGTGTGCCCGGGCGCTGGGCGTTCAGAATCGATGATGCCCAGGTGCGCGTGGGGGGCTGCGGCCAT       ACAACGTCCGTGTGCCTGGCCCTGCGCCCCTGCCTCAACGGCGGCAAGTGCATCGACGACTGCGTCAC       GGGCAACCCCTCCTACACCTGCTCCTGCCTCTCGGGCTTCACGGGGCGGAGGTGCCACCTGGACGTGA       ACGAATGTGCCTCCCAGCCCTGTCAGAATGGTGGGACCTGTACTCACGGCATCAACAGTTTCCGCTGC       CAGTGCCCGGCTGGCTTTGGGGGACCCACCTGTGAGACAGCCCAATCCCCCTGTGACACCAAAGAGTG       TCAACATGGTGGCCAGTGCCAGGTGGAGAACGGCTCTGCGGTGTGTGTGTGCCAGGCCGGATACACCG       GAGCAGCCTGCGAGATGGATGTGGACGACTGCAGCCCTGACCCCTGCCTGAATGGAGGCTCTTGTGTT       GACCTAGTGGGGAATTACACCTGCTTGTGTGCCGAGCCCTTCAAGGGACTTCGCTGTGAGACAGGAGA       CCATCCAGTGCCAGACGCCTGCCTCTCGGCCCCTTGCCACAATGGGGGCACCTGTGTGGATGCGGACC       AGGGCTACGTGTGCGAGTGCCCCGAAGGCTTCATGGGCCTGGACTGCAGGGAGAGAGTCCCCGATGAC       TGTGAGTGCCGCAACGGAGGCAGATGCCTGGGCGCCAACACCACCCTCTGCCAGTGCCCCCTGGGATT       CTTTGGGCTTCTCTGTGAATTTGAAATCACAGCCATGCCCTGCAACATGAACACACAGTGCCCAGATG       GGGGCTACTGCATGGAGCACGGCGGGAGCTACCTCTGCGTCTGCCACACCGACCACAATGCCAGCCAC       TCCCTGCCATCACCCTGCGACTCGGACCCCTGCTTCAACGGAGGCTCCTGCGATGCCCATGACGACTC       CTACACCTGCGAGTGCCCGCGCGGGTTCCACGGCAAGCACTGCGAGAAAGCCCGGCCACACCTGTGCA       GCTCAGGGCCCTGCCGGAACGGGGGCACGTGCAAGGAGGCGGGCGGCGAGTACCACTGCAGCTGCCCC       TACCGCTTCACTGGGAGGCACTGTGAGATCGGGAAGCCAGACTCGTGTGCCTCTGGCCCCTGTCACAA       CGGCGGCACCTGCTTCCACTACATTGGCAAATACAAGTGTGACTGTCCCCCAGGCTTCTCCGGGCGGC       ACTGCGAGATAGCCCCCTCCCCCTGCTTCCGGAGCCCGTGTGTGAATGGGGGCACCTGCGAGGACCGG       GACACGGATTTCTTCTGCCACTGCCAAGCAGGGTACATGGGACGCCGGTGCCAGGCAGAGGTGGACTG       CGGCCCCCCGGAGGAGGTGAAGCACGCCACACTGCGCTTCAACGGCACGCGGCTGGGCGCGGTGGCCC       TGTATGCATGTGACCGTGGCTACAGCCTGAGCGCCCCCAGCCGCATCCGGGTCTGCCAGCCACACGGT       GTCTGGAGTGAGCCTCCCCAGTGCCTTGAAATCGATGAGTGCCGGTCTCAGCCGTGCCTGCATGGGGG       CTCTTGTCAGGACCGCGTTGCTGGGTACCTGTGCCTCTGCAGCACAGGCTATGAGGGCGCCCACTGTG       AGCTGGAGAGGGATGAGTGCCGAGCTCACCCGTGCAGAAATGGAGGGTCCTGCAGGAACCTCCCAGGG       CTCCAGCCCCTGCCAGCATGGAGGCCGGTGTGAGAGCGGCGGCGGGGCCTACCTGTGCGTCTGCCCAG       GCCTATGTCTGCCGGTGCCCTGCAGGCTTCGTTGGAGTCCACTGTGAGACAGAGGTGGACGCCTGCGA       AGAGCTTCTTCGGCTACCACTGCGAGACAGTGAGTGACCCCTGCTTCTCCAGCCCCTGTGGGGGCCGT       GGCTATTGCCTGGCCAGCAACGGCTCCCACAGCTGCACCTGCAAAGTGGGCTACACGGGCGAGGACTG       CGCCAAAGAGCTCTTCCCACCGACGGCCCTCAAGATGGAGAGAGTGGAGGAGAGTGGGGTCTCTATCT       CCTGGAACCCGCCCAATGGTCCAGCCGCCAGGCAGATGCTTGATGGCTACGCGGTCACCTACGTCTCC       TCCGACGGCTCCTACCGCCGCACAGACTTTGTGGACAGGACCCGCTCCTCGCACCAGCTCCAGGCCCT       GGCGGCCGGCAGGGCCTACAACATCTCCGTCTTCTCAGTGAAGCGAAACAGTAACAACAAGAATGACA       TCAGCAGGCCTGCCGTGCTGCTGGCCCGCACGCGACCCCGCCCTGTGGAAGGCTTCGAGGTCACCAAT       GTGACGGCTAGCACCATCTCAGTGCAGTGGGCCCTGCACAGGATCCGCCATGCCACCGTCAGTGGGGT       CCGTGTGTCCATCCGCCACCCTGAGGCCCTCAGGGACCAGGCCACCGATGTGGACAGGAGTGTGGACA       GGTTCACCTTTAGGGCCCTGCTGCCTGGGAAGAGGTACACCATCCAGCTGACCACCCTCAGTGGGCTC       AGGGGAGAGGAGCACCCCACAGAGAGCCTGGCCACCGCGCCGACGCACGTGTGGACCCGGCCCCTGCC       TCCAGCAAACCTGACCGCCGCCCGAGTCACTGCCACCTCTGCCCACGTGGTCTGGGATGCCCCGACTC       CAGGCAGCTTGCTGGAGGCTTATGTCATCAATGTGACCACCAGCCAGAGCACCAAGAGCCGCTATGTC       CCCAACGGGAAGCTGGCGTCCTACACGGTGCGCGACCTGCTGCCGGGACGGCGGTACCAGCCCTCTGT       GATAGCAGTGCAGAGCACGGAGCTCGGGCCGCAGCACAGCGAGCCCGCCCACCTCTACATCATCACCT       CCCCCAGGGATGGCGCTGACAGACGCTGGCACCAGGGAGGACACCACCCTCGGGTGCTCAAGAACAGA       CCGCCCCCGGCGCGCCTGCCGGAGCTGCGCCTGCTCAATGACCACAGCGCCCCCGAGACCCCCACCCA       GCCCCCCAGGTTCTCGGAGTTTGTGGACGGCAGAGGAAGAGTGAGCGCCAGGTTCGGTGGCTCACCCA       GCAAAGCAGCCACCGTGAGATCACAACCCACAGCCTCGGCGCAGCTCGAGAACATGGAGGAAGCCCCC       AAGCGGGTCAGCCCGGCCCTCCAGCTCCCTGAACACGGCAGCAAGGACATCGGAAACGTCCCTGGCAA       CTGTTCAGAAAACCCCTGTCAGAACGGAGGCACTTGTGTGCCGGGCGCAGACGCCCACAGCTGTGACT       GCGGGCCAGGGTTCAAAGGCAGACGCTGCGAGCTCGCCTGTATAAAGGTGTCCCGCCCCTGCACAAGG       CTGTTCTCCGAGACAAAGGCCTTTCCAGTCTGGGAGGGAGGCGTCTGTCACCACGTGTATAAAAGAGT       CTACCGAGTTCACCAAGACATCTGCTTCAAAGAGAGCTGTGAAAGCACAAGCCTCAAGAAGACCCCAA       ACAGGAAACAAAGTAAGAGTCAGACACTGGAGAAATCT TAA   GAAAGAAGGAACAGGCAATGTAGAGAA           GCTGTCAAATGGTGGACTCCCAAACCGTTCCACCACTGCCTCAAAAAACATCTTGACCAGCAGAAGGT           GGAGCTCAATGAAGGGTCAAGAGCTCAGCGAAGGGTAACTAGGTGGAACTGAGAGAAACCACGTTCAC           AAACTGCGTAATGCGGACTTCCTGCCGCCCTGGAGACCCCTCAACTCTCTGTCCATGTAAGGCCCTTA           AAGAGATTCATAGGAACTTTGAGCATCCTTNAGATGTGAATATTGTTGGGGGCAGGATTGGGGGATAA           ATAGAAGGGAAGGCCACTCCACGAGTATCCCATGAACCTGGCCAGATCT                                           NOV58b, CG93387-01   SEQ ID NO:1146   1288 aa   MW at 138908.1 kD           Protein Sequence                     MLRRATEDVRHYFPELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGKLSFTIFNYESIVW           TTGTHASSGGNATGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTNVGVPGRWAFRIDDAQVR       VGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHG       INSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPCL       NGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCR       ERVPDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHT       DHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGE       YHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNG       GTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIR       VCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGS       CRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFS       SPCGGRGYCLASNGSHSCTCKVGYTGEDCAKELFPPTALKMERVEESGVSISWNPPNGPAARQMLDGY       AVTYVSSDGSYRRTDFVDRTRSSHQLQALAAGRAYNISVFSVKRNSNNKNDISRPAVLLARTRPRPVE       GFEVTNVTASTISVQWALHRIRHATVSGVRVSIRHPEALRDQATDVDRSVDRFTFRALLPGKRYTIQL       TTLSGLRGEEHPTESLATAPTHVWTRPLPPANLTAARVTATSAHVVWDAPTPGSLLEAYVINVTTSQS       TKSRYVPNGKLASYTVRDLLPGRRYQPSVIAVQSTELGPQHSEPAHLYIITSPRDGADRRWHQGGHHP       RVLKNRPPPARLPELRLLNDHSAPETPTQPPRFSEFVDGRGRVSARFGGSPSKAATVRSQPTASAQLE       NMEEAPKRVSPALQLPEHGSKDIGNVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKV       SRPCTRLFSETKAFPVWEGGVCHHVYKRVYRVHQDICFKESCESTSLKKTPNRKQSKSQTLEKS                                     NOV58c, CG93387-02   SEQ ID NO:1147   4413 bp           DNA Sequence   ORF Start: ATG at 181   ORF Stop: TAG at 4405                       GAGCACTCCGGACTCTACGTGAACAACAACGGGATCATCTCCTTCCTGAAGGAGGTTTCTCAGTTCAC               CCCAGTGGCCTTCCCCATTGCCAAGGACCGCTGCGTGGTGGCAGCCTTCTGGGCAGATGTGGACAACC           GGCGTGCAGGCGACGTGTACTACCGGGAGGCCACCGACCCAGCC   ATG CTGCGCCGAGCCACGGAGGAC       GTCAGGCACTACTTCCCCGAGCTCCTGGACTTCAATGCCACCTGGGTTTTTGTTGCCACCTGGTACCG       AGTGACCTTCTTTGGAGGCAGTTCCTCATCCCCTGTCAACACATTCCAGACTGTGCTCATCACAGACG       GCAAGCTCTCCTTCACCATCTTCAACTATGAGTCCATCGTGTGGACCACAGGCACACACGCCAGCAGC       GGGGGCAACGCCACTGGCCTCGGGGGCATCGCAGCCCAGGCTGGCTTCAACGCAGGCGATGGGCAGCG       TTACTTCAGTATCCCCGGCTCGCGCACAGCAGACATGGCCGAGGTGGAGACCACCACCATCGTGGTTG       TGCCCGGGCGCTGGGCGTTCATAATCGATGATGCCCAGGTGCGCGTGGGGGGCTGCGGCCATACAACG       TCCGTGTGCCTGGCCCTGCGCCCCTGCCTCAACGGCGGCAAGTGCATCGACGACTGCGTCACGGGCAA       CCCCTCCTACACCTGCTCCTGCCTCTCGGGCTTCACGGGGCGGAGGTGCCACCTGGACGTGAACGAAT       GTGCCTCCCAGCCCTGTCAGAATGGTGGGACCTGTACTCACGGCATCAACAGTTTCCGCTGCCAGTGC       CCGGCTGGCTTTGGGGGACCCACCTGTGAGACAGCCCAATCCCCCTGTGACACCAAAGAGTGTCAACA       TGGTGGCCAGTGCCAGGTGGAGAATGGCTCTGCGGTGTGTGTGTGCCAGGCCGGATACACCGGAGCAG       CCTGCGAGATGGATGTGGACGACTGCAGCCCTGACCCCTGCCTGAATGGAGGCTCTTGTGTTGACCTA       GTGGGGAATTACACCTGCTTGTGTGCCGAGCCCTTCAAGGGACTTCGCTGTGAGACAGGAGACCATCN       NCAGTGCCAGACGCCTGCCTCTCGGCCCCTTGCCACAATGGGGGCACCTGTGTGGATGCGGACCAGGG       CTACGTGTGCGAGTGCCCCGAAGGCTTCATGGGCCTGGACTGCAGGGAGAGAGTCCCCGATGACTGTG       AGTGCCGCAACGGAGGCAGATGCCTGGGCGCCAACACCACCCTCTGCCCAGTGCCCCCTGGGATTCTT       TGGGCTTCTCTGTGAATTTGAAATCACAGCCATGCCCTGCAACATGAACACACAGTGCCCAGATGGGG       GCTACTGCATGGAGCACGGCGGGAGCTACCTCTGCGTCTGCCACACCGACCACAATGCCAGCCACTCC       CTGCCATCACCCTGCGACTCGGACCCCTGCTTCAACGGAGGCTCCTGCGATGCCCATGACGACTCCTA       CACCTGCGAGTGCCCGCGCGGGTTCCACGGCAAGCACTGCGAGAAAGCCCGGCCACACCTGTGCAGCT       CAGGGCCCTGCCGGAACGGGGGCACGTGCAAGGAGGCGGGCGGCGACTACCACTGCAGCTGCCCCTAC       CGCTTCACTGGGAGGCACTGTGAGATCGGGAAGCCAGACTCGTGTGCCTCTGGCCCCTGTCACAACGG       CGGCACCTGCTTCCACTACATTGGCAAATACAAGTGTGACTGTCCCCCAGGCTTCTCCGGGCGGCACT       GCGAGATAGCCCCCTCCCCCTGCTTCCGGAGCCCGTGTGTGAATGGGGGCACCTGCGAGGACCGGGAC       ACGGATTTCTTCTGCCACTGCCAAGCAGGGTACATGGGACGCCGGTGCCAGGCAGAGGTGGACTGCGG       CCCCCCGGAGGAGGTGAAGCACGCCACACTGCGCTTCAACGGCACGCGGCTGGGCGCGGTGGCCCTGT       ATGCATGTGACCGTGGCTACAGCCTGAGCGCCCCCAGCCGCATCCGGGTCTGCCAGCCACACGGTGTC       TGGAAAATCGATGAGTGCCGGTCTCAGCCGTGCCTGCATGGGGGCTCTTGTCAGGACCGCGTTGCTGG       GTACCTGTGCCTCTGCAGCACAGGCTATGAGGGCGCCCACTGTGAGCTGGAGAGGGATGAGTGCCGAG       CTCACCCGTGCAGAAATGGAGGGTCCTGCAGGAACCTCCCAGGGGCCTATGTCTGCCGGTGCCCTGCA       GGCTTCGTTGGAGTCCACTGTGAGACAGAGGTGGACGCCTGCGACTCCAGCCCCTGCCAGCATGGAGG       CCGGTGTGAGAGCGGCGGCGGGGCCTACCTGTGCGTCTGCCCAGAGAGCTTCTTCGGCTACCACTGCG       AGACAGTGAGTGACCCCTGCTTCTCCAGCCCCTGTGGGGGCCGTGGCTATTGCCTGGCCAGCAACGGC       TCCCACAGCTGCACCTGCAAAGTGGGCTACACGGGCGAGGACTGCGCCAAAGAGCTCTTCCCACCGAC       GGCCCTCAAGATGGAGAGAGTGGAGGAGAGTGGGGTCTCTATCTCCTGGAACCCGCCCAATGGTCCAG       CCGCCAGGCAGATGCTTGATGGCTACGCGGTCACCTACGTCTCCTCCGACGGCTCCTACCGCCGCACA       GACTTTGTGGACAGGACCCGCTCCTCGCACCAGCTCCAGGCCCTGGCGGCCGGCAGGGCCTACAACAT       CTCCGTCTTCTCAGTGAAGCGAAACAGTAACAACAAGAATGACATCAGCAGGCCTGCCGTGCTGCTGG       CCCGCACGCGACCCCGCCCTGTGGAAGGCTTCGAGGTCACCAATGTGACGGCTAGCACCATCTCAGTG       CAGTGGGCCCTGCACAGGATCCGCCATGCCACCGTCAGTGGGGTCCGTGTGTCCATCCGCCACCCTGA       GGCCCTCAGGGACCAGGCCACCGATGTGGACAGGAGTGTGGACAGGTTCACCTTTAGGGCCCTGCTGC       CTGGGAAGAGGTACACCATCCAGCTGACCACCCTCAGTGGGCTCAGGGGAGAGGAGCACCCCACAGAG       AGCCTGGCCACCGCGCCGACGCACGTGTGGACCCGGCCCCTGCCTCCAGCAAACCTGACCGCCGCCCG       AGTCACTGCCACCTCTGCCCACGTGGTCTGGGATGCCCCGACTCCAGGCAGCTTGCTGGAGGCTTATG       TCATCAATGTGACCACCAGCCAGAGCACCAAGAGCCGCTATGTCCCCAACGGGAAGCTGGCGTCCTAC       ACGGTGCGCGACCTGCTGCCGGGACGGCGGTACCAGCTCTCTGTGATAGCAGTGCAGAGCACGGAGCT       CGGGCCGCAGCACAGCGAGCCCGCCCACCTCTACATCATCACCTCCCCCAGGGATGGCGCTGACAGAC       GCTGGCACCAGGGAGGACACCACCCTCGGGTGCTCAAGAACAGACCGCCCCCGGCGCGCCTGCCGGAG       CTGCGCCTGCTCAATGACCACAGCGCCCCCGAGACCCCCACCCAGCCCCCCAGGTTCTCGGAGCTTGT       GGACGGCAGAGGAAGAGTGAGCGCCAGGTTCGGTGGCTCACCCAGCAAAGCAGCCACCGTGAGATCAC       GTCCTGTCCCCTACATGATGAGCCCACCCCCACCGCCAGCGCAGTCTCCAGCCAGTGACCCCCACCCC       GACTGTGCACAAGGCGCGGGGCTCGTGGGCCGCCGGCAGCATGCACCTCCATGGCAGGAGGGGCAGCT       CGGACATCCGTGCTCCCTGAGATATAGAAGCACTCAAAAGGGTGGCCCCAGGACCATCCCGGGTGCAA       AGCAGCTGCGCCGTGTGGTCACCGCCTGGCTTCTCCTAGAACCCACAGCCTCGGCGCAGCTCGAGAAC       ATGGAGGAAGCCCCCAAGCGGGTCAGCCTGGCCCTCCAGCTCCCTGAACACGGCAGCAAGGACATCGG       AAGTTATGCAGGACCTGAACTGTCTCCTAGTCCGGGGCTCTGCCTCGTGAGGATCGAGGCCAGCACGT       CCCTGCAGGGCACCAAGCATCTGCTGAGCACCTGCAGCACACAAGCAAAGGAGCAGGGTGGAGCCTTC       ACGCTGCCGTGCCTGTGTGGACCAGTCCAGGGTGACCACGGGGTAGGTGAGGGAAAGCCTGTCTTCAC       AGACCACTCTCCAGCTGACGTCCCTGGCAACTGTTCAGAAAACCCCTGTCAGAACGGAGGCACTTGTG       TGCCGGGCGCAGACGCCCACAGCTGTGACTGCGGGCCAGGGTTCAAAGGCAGACGCTGCGAGCTCGGT       ATAAAAGAGTCTACCGAGTTCACCAAGACATCTGCTTCAAAGAGAGCTGTGAAAGCACAAGCCTCAAG       AAGACCCCAAACAGGTGCCTCTGGGGAGCAGGCCCATGCCGTGTCCTGCATG TAG   NNNNNN                                           NOV58c, CG93387-02   SEQ ID NO:1148   1408 aa   MW at 150587.4 kD           Protein Sequence                     MLRRATEDVRHYFPELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGKLSFTIFNYESIVW           TTGTHASSGGNATGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTIVVVPGRWAFIIDDAQVR       VGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHG       INSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPCL       NGGSCVDLVFNYTCLCAEPFKGLRCETGDHXQCQTPASRPLATMGAPVWMRTRATCASAPKASWAWTA       GRESPMTVSAATEADAWAPTPPSAWCPLGFFGLLCEFEITAMPCNMNTWCPDGGYCMEHGGSYLCVCH       TDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGG       EYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVN       GGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRI       RVCQPHGVWKIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPG       AYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGR       GYCLASNGSHSCTCKVGYTGEDCAKELFPPTALKMERVEESGVSISWNPPNGPAARQMLDGYAVTYVS       SDGSYRRTDFVDRTRSSHQLQALAAGPAYNISVFSVKRNSNNKNDISRPAVLLARTRPRPVEGFEVTN       VTASTISVQWALHRIRHATVSGVRVSIRHPEALRDQATDVDRSVDRFTFRALLPGKRYTIQLTTLSGL       RGEEHPTESLATAPTHVWTRPLPPANLTAARVTATSAHVVWDAPTPGSLLEAYVINVTTSQSTKSRYV       PNGKLASYTVRDLLPGRRYQLSVIAVQSTELGPQHSEPAHLYIITSPRDGADRRWHQGGHHPRVLKNR       PPPARLPELRLLNDHSAPETPTQPPRFSELVDGRGRVSARFGGSPSKAATVRSRPVPYMMSPPPPPAQ       SPASDPHPDCAQGAGLVGRRQHAPPWQEGQLGHPCSLRYRSTQKGGPRTIPGAKQLRRVVTAWLLLEP       TASAQLENMEEAPKRVSLALQLPEHGSKDIGSYAGPELSPSPGLCLVRIEASTSLQGTKHLLSTCSTQ       AKEQGGAFTLPCLCGPVQGDHGVGEGKPVFTDHSPADVPGNCSENPCQNGGTCVPGADAHSCDCGPGF       KGRRCELGIKESTEFTKTSASKRAVKAQASRPPQTGASGEQAHAVSCM                                     NOV58d, CG93387-03   SEQ ID NO:1149   2877 bp           DNA Sequence   ORF Start: ATG at 6   ORF Stop: TAA at 2868                       GCTTC   ATG GGCCTGGACTGCAGGGAGAGAGTCCCCGATGACTGTGAGTGCCGCAACGGAGGCAGATGC           CTGGGCGCCAACACCACCCTCTGCCAGTGCCCCCTGGGATTCTTTGGGCTTCTCTGTGAATTTGAAAT       CACAGCCATGCCCTGCAACATGAACACACAGTGCCCAGATGGGGGCTACTGCATGGAGCACGGCGGGA       GCTACCTCTGCGTCTGCCACACCGACCACAATGCCAGCCACTCCCTGCCATCACCCTGCGACTCGGAC       CCCTGCTTCAACGGAGGCTCCTGCGATGCCCATGACGACTCCTACACCTGCGAGTGCCCGCGCGGGTT       CCACGGCAAGCACTGCGAGAAAGCCCGGCCACACCTGTGCAGCTCAGGGCCCTGCCGGAACGGGGGCA       CGTGCAAGGAGGCGGGCGGCGAGTACCACTGCAGCTGCCCCTACCGCTTCACTGGGAGGCACTGTGAG       ATCGGGAAGCCAGACTCGTGTGCCTCTGGCCCCTGTCACAACGGCGGCACCTGCTTCCACTACATTGG       CAAATACAAGTGTGACTGTCCCCCAGGCTTCTCCGGGCGGCACTGCGAGATAGCCCCCTCCCCCTGCT       TCCGGAGCCCGTGTGTGAATGGGGGCACCTGCGAGGACCGGGACACGGATTTCTTCTGCCACTGCCAA       GCAGGGTACATGGGACGCCGGTGCCAGGCAGAGGTGGACTGCGGCCCCCCGGAGGAGGTGAAGCACGC       CACACTGCGCTTCAACGGCACGCGGCTGGGCGCGGTGGCCCTGTATGCATGTGACCGTGGCTACAGCC       TGAGCGCCCCCAGCCGCATCCGGGTCTGCCAGCCACACGGTGTCTGGAGTGAGCCTCCCCAGTGCCTT       GAAATCGATGAGTGCCGGTCTCAGCCGTGCCTGCATGGGGGCTCTTGTCAGGACCGCGTTGCTGGGTA       CCTGTGCCTCTGCAGCACAGGCTATGAGGGCGCCCACTGTGAGCTGGAGAGGGATGAGTGCCGAGCTC       ACCCGTGCAGAAATGGAGGGTCCTGCAGGAACCTCCCAGGGGCCTATGTCTGCCGGTGCCCTGCAGGC       TTCGTTGGAGTCCACTGTGAGACAGAGGTGGACGCCTGCGACTCCAGCCCCTGCCAGCATGGAGGCCG       GTGTGAGAGCGGCGGCGGGGCCTACCTGTGCGTCTGCCCAGAGAGCTTCTTCGGCTACCACTGCGAGA       CAGTGAGTGACCCCTGCTTCTCCAGCCCCTGTGGGGGCCGTGGCTATTGCCTGGCCAGCAACGGCTCC       CACAGCTGCACCTGCAAAGTGGGCTACACGGGCGAGGACTGCGCCAAAGAGCTCTTCCCACCGACGGC       CCTCAAGATGGAGAGAGTGGAGGAGAGTGGGGTCTCTATCTCCTGGAACCCGCCCAATGGTCCAGCCG       CCAGGCAGATGCTTGATGGCTACGCGGTCACCTACGTCTCCTCCGACGGCTCCTACCGCCGCACAGAC       TTTGTGGACAGGACCCGCTCCTCGCACCAGCTCCAGGCCCTGGCGGCCGGCAGGGCCTACAACATCTC       CGTCTTCTCAGTGAAGCGAAACAGTAACAACAAGAATGACATCAGCAGGCCTGCCGTGCTGCTGGCCC       GCACGCGACCCCGCCCTGTGGAAGGCTTCGAGGTCACCAATGTGACGGCTAGCACCATCTCAGTGCAG       TGGGCCCTGCACAGGATCCGCCATGCCACCGTCAGTGGGGTCCGTGTGTCCATCCGCCACCCTGAGGC       CCTCAGGGACCAGGCCACCGATGTGGACAGGAGTGTGGACAGGTTCACCTTTAGGGCCCTGCTGCCTG       GGAAGAGGTACACCATCCAGCTGACCACCCTCAGTGGGCTCAGGGGAGAGGAGCACCCCACAGAGAGC       CTGGCCACCGCGCCGACGCACGTGTGGACCCGGCCCCTGCCTCCAGCAAACCTGACCGCCGCCCGAGT       CACTGCCACCTCTGCCCACGTGGTCTGGGATGCCCCGACTCCAGGCAGCTTGCTGGAGGCTTATGTCA       TCAATGTGACCACCAGCCAGAGCACCAAGAGCCGCTATGTCCCCAACGGGAAGCTGGCGTCCTACACG       GTGCGCGACCTGCTGCCGGGACGGCGGTACCAGCCCTCTGTGATAGCAGTGCAGAGCACGGAGCTCGG       GCCGCAGCACAGCGAGCCCGCCCACCTCTACATCATCACCTCCCCCAGGGATGGCGCTGACAGACGCT       GGCACCAGGGAGGACACCACCCTCGGGTGCTCAAGAACAGACCGCCCCCGGCGCGCCTGCCGGAGCTG       CGCCTGCTCAATGACCACAGCGCCCCCGAGACCCCCACCCAGCCCCCCAGGTTCTCGGAGTTTGTGGA       CGGCAGAGGAAGAGTGAGCGCCAGGTTCGGTGGCTCACCCAGCAAAGCAGCCACCGTGAGATCACAAC       CCACAGCCTCGGCGCAGCTCGAGAACATGGAGGAAGCCCCCAAGCGGGTCAGCCCGGCCCTCCAGCTC       CCTGAACACGGCAGCAAGGACATCGGAAACGTCCCTGGCAACTGTTCAGAAAACCCCTGTCAGAACGG       AGGCACTTGTGTGCCGGGCGCAGACGCCCACAGCTGTGACTGCGGGCCAGGGTTCAAAGGCAGACGCT       GCGAGCTCGCCTGTATAAAGGTGTCCCGCCCCTGCACAAGGCTGTTCTCCGAGACAAAGGCCTTTCCA       GTCTGGGAGGGAGGCGTCTGTCACCACGTGTATAAAAGAGTCTACCGAGTTCACCAAGACATCTGCTT       CAAAGAGAGCTGTGAAAGCACAAGCCTCAAGAAGACCCCAAACAGGAAACAAAGTAAGAGTCAGACAC       TGGAGAAATCT TAA   GAAAGAA                                           NOV58d, CG93387-03   SEQ ID NO:1150   954 aa   MW at 103791.4 kD           Protein Sequence                     MGLDCRERVPDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNNNTQCPDGGYCMEHGGSY           LCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTC       KEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFR       SPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLS       APSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHP       CRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETV       SDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKELFPPTALKMERVEESGVSISWNPPNGPAAR       QMLDGYAVTYVSSDGSYRRTDFVDRTRSSHQLQALAAGRAYNISVFSVKRNSNNKNDISRPAVLLART       RPRPVEGFEVTNVTASTISVQWALHRIRHATVSGVRVSIRHPEALRDQATDVDRSVDRFTFRALLPGK       RYTIQLTTLSGLRGEEHPTESLATAPTHVWTRPLPPANLTAARVTATSAHVVWDAPTPGSLLEAYVIN       VTTSQSTKSRYVPNGKLASYTVRDLLPGRRYQPSVIAVQSTELGPQHSEPAHLYIITSPRDGADRRWH       QGGHHPRVLKNRPPPARLPELRLLNDHSAPETPTQPPRFSEFVDGRGRVSARFGGSPSKAATVRSQPT       ASAQLENMEEAPKRVSPALQLPEHGSKDIGNVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE       LACIKVSRPCTRLFSETKAFPVWEGGVCHHVYKRVYRVHQDICFKESCESTSLKKTPNRKQS       KSQTLEKS                             NOV58e, CG93387-04   SEQ ID NO:1151   j7459 bp           DNA Sequence   lORF Start: ATG at 182   lORF Stop: TAA at 4046                       GAGCACTCCGGACTCTACGTGAACAACAACGGGATCATCTCCTTCCTGAAGGAGGTTTCTCAGTTTCA               CCCCAGTGGCCTTCCCCATTGCCAAGGACCGCTGCGTGGTGGCAGCCTTCTGGGCAGATGTGGACAAC           CGGCGTGCAGGCGACGTGTACTACCGGGAGGCCACCGACCCAGCC   ATG CTGCGCCGAGCCACGGAGGA       CGTCAGGCACTACTTCCCCGAGCTCCTGGACTTCAATGCCACCTGGGTTTTTGTTGCCACCTGGTACC       GAGTGACCTTCTTTGGAGGCAGTTCCTCATCCCCTGTCAACACATTCCAGACTGTGCTCATCACAGAC       GGCAAGCTCTCCTTCACCATCTTCAACTATGAGTCCATCGTGTGGACCACAGGCACACACGCCAGCAG       CGGGGGCAACGCCACTGGCCTCGGGGGCATCGCAGCCCAGGCTGGCTTCAACGCAGGCGATGGGCAGC       GTTACTTCAGTATCCCCGGCTCGCGCACAGCAGACATGGCCGAGGTGGAGACCACCACCAACGTGGGT       GTGCCCGGGCGCTGGGCGTTCAGAATCGATGATGCCCAGGTGCGCGTGGGGGGCTGCGGCCATACAAC       GTCCGTGTGCCTGGCCCTGCGCCCCTGCCTCAACGGCGGCAAGTGCATCGACGACTGCGTCACGGGCA       ACCCCTCCTACACCTGCTCCTGCCTCTCGGGCTTCACGGGGCGGAGGTGCCACCTGGACGTGAACGAA       TGTGCCTCCCAGCCCTGTCAGAATGGTGGGACCTGTACTCACGGCATCAACAGTTTCCGCTGCCAGTG       CCCGGCTGGCTTTGGGGGACCCACCTGTGAGACAGCCCAATCCCCCTGTGACACCAAAGAGTGTCAAC       ATGGTGGCCAGTGCCAGGTGGAGAATGGCTCTGCGGTGTGTGTGTGCCAGGCCGGATACACCGGAGCA       GCCTGCGAGATGGATGTGGACGACTGCAGCCCTGACCCCTGCCTGAATGGAGGCTCTTGTGTTGACCT       AGTGGGGAATTACACCTGCTTGTGTGCCGAGCCCTTCAAGGGACTTCGCTGTGAGACAGGAGACCATC       CAGTGCCAGACGCCTGCCTCTCGGCCCCTTGCCACAATGGGGGCACCTGTGTGGATGCGGACCAGGGC       TACGTGTGCGAGTGCCCCGAAGGCTTCATGGGCCTGGACTGCAGGGAGAGAGTCCCCGATGACTGTGA       GTGCCGCAACGGAGGCAGATGCCTGGGCGCCAACACCACCCTCTGCCAGTGCCCCCTGGGATTCTTTG       GGCTTCTCTGTGAATTTGAAATCACAGCCATGCCCTGCAACATGAACACACAGTGCCCAGATGGGGGC       TACTGCATGGAGCACGGCGGGAGCTACCTCTGCGTCTGCCACACCGACCACAATGCCAGCCACTCCCT       GCCATCACCCTGCGACTCGGACCCCTGCTTCAACGGAGGCTCCTGCGATGCCCATGACGACTCCTACA       CCTGCGAGTGCCCGCGCGGGTTCCACGGCAAGCACTGCGAGAAAGCCCGGCCACACCTGTGCAGCTCA       GGGCCCTGCCGGAACGGGGGCACGTGCAAGGAGGCGGGCGGCGAGTACCACTGCAGCTGCCCCTACCG       CTTCACTGGGAGGCACTGTGAGATCGGGAAGCCAGACTCGTGTGCCTCTGGCCCCTGTCACAACGGCG       GCACCTGCTTCCACTACATTGGCAAATACAAGTGTGACTGTCCCCCAGGCTTCTCCGGGCGGCACTGC       GAGATAGCCCCCTCCCCCTGCTTCCGGAGCCCGTGTGTGAATGGGGGCACCTGCGAGGACCGGGACAC       GGATTTCTTCTGCCACTGCCAAGCAGGGTACATGGGACGCCGGTGCCAGGCAGAGGTGGACTGCGGCC       CCCCGGAGGAGGTGAAGCACGCCACACTGCGCTTCAACGGCACGCGGCTGGGCGCGGTGGCCCTGTAT       GCATGTGACCGTGGCTACAGCCTGAGCGCCCCCAGCCGCATCCGGGTCTGCCAGCCACACGGTGTCTG       GAGTGAGCCTCCCCAGTGCCTTGAAATCGATGAGTGCCGGTCTCAGCCGTGCCTGCATGGGGGCTCTT       GTCAGGACCGCGTTGCTGGGTACCTGTGCCTCTGCAGCACAGGCTATGAGGGCGCCCACTGTGAGCTG       GAGAGGGATGAGTGCCGAGCTCACCCGTGCAGAAATGGAGGGTCCTGCAGGAACCTCCCAGGGGCCTA       TGTCTGCCGGTGCCCTGCAGGCTTCGTTGGAGTCCACTGTGAGACAGAGGTGGACGCCTGCGACTCCA       GCCCCTGCCAGCATGGAGGCCGGTGTGAGAGCGGCGGCGGGGCCTACCTGTGCGTCTGCCCAGAGAGC       TTCTTCGGCTACCACTGCGAGACAGTGAGTGACCCCTGCTTCTCCAGCCCCTGTGGGGGCCGTGGCTA       TTGCCTGGCCAGCAACGGCTCCCACAGCTGCACCTGCAAAGTGGGCTACACGGGCGAGGACTGCGCCA       AAGAGCTCTTCCCACCGACGGCCCTCAAGATGGAGAGAGTGGAGGAGAGTGGGGTCTCTATCTCCTGG       AACCCGCCCAATGGTCCAGCCGCCAGGCAGATGCTTGATGGCTACGCGGTCACCTACGTCTCCTCCGA       CGGCTCCTACCGCCGCACAGACTTTGTGGACAGGACCCGCTCCTCGCACCAGCTCCAGGCCCTGGCGG       CCGGCAGGGCCTACAACATCTCCGTCTTCTCAGTGAAGCGAAACAGTAACAACAAGAATGACATCAGC       AGGCCTGCCGTGCTGCTGGCCCGCACGCGACCCCGCCCTGTGGAAGGCTTCGAGGTCACCAATGTGAC       GGCTAGCACCATCTCAGTGCAGTGGGCCCTGCACAGGATCCGCCATGCCACCGTCAGTGGGGTCCGTG       TGTCCATCCGCCACCCTGAGGCCCTCAGGGACCAGGCCACCGATGTGGACAGGAGTGTGGACAGGTTC       ACCTTTAGGGCCCTGCTGCCTGGGAAGAGGTACACCATCCAGCTGACCACCCTCAGTGGGCTCAGGGG       AGAGGAGCACCCCACAGAGAGCCTGGCCACCGCGCCGACGCACGTGTGGACCCGGCCCCTGCCTCCAG       CAAACCTGACCGCCGCCCGAGTCACTGCCACCTCTGCCCACGTGGTCTGGGATGCCCCGACTCCAGGC       AGCTTGCTGGAGGCTTATGTCATCAATGTGACCACCAGCCAGAGCACCAAGAGCCGCTATGTCCCCAA       CGGGAAGCTGGCGTCCTACACGGTGCGCGACCTGCTGCCGGGACGGCGGTACCAGCCCTCTGTGATAG       CAGTGCAGAGCACGGAGCTCGGGCCGCAGCACAGCGAGCCCGCCCACCTCTACATCATCACCTCCCCC       AGGGATGGCGCTGACAGACGCTGGCACCAGGGAGGACACCACCCTCGGGTGCTCAAGAACAGACCGCC       CCCGGCGCGCCTGCCGGAGCTGCGCCTGCTCAATGACCACAGCGCCCCCGAGACCCCCACCCAGCCCC       CCAGGTTCTCGGAGTTTGTGGACGGCAGAGGAAGAGTGAGCGCCAGGTTCGGTGGCTCACCCAGCAAA       GCAGCCACCGTGAGATCACAACCCACAGCCTCGGCGCAGCTCGAGAACATGGAGGAAGCCCCCAAGCG       GGTCAGCCCGGCCCTCCAGCTCCCTGAACACGGCAGCAAGGACGTCGGAAACGTCCCTGGCAACTGTT       CAGAAAACCCCTGTCAGAACGGAGGCACTTGTGTGCCGGGCGCAGACGCCCACAGCTGTGGCTGCGGG       CCAGGGTTCAAAGGCAGACGCTGCGAGCTCGCCTGTATAAAGGTGTCCCGCCCCTGCACAAGGCTGTT       CTCCGAGACAAAGGCCTTTCCAGTCTGGGAGGGAGGCGTCTGTCACCACGTGTATAAAAGAGTCTACC       GAGTTCACCAAGACATCTGCTTCAAAGAGAGCTGTGAAAGCACAAGCCTCAAGAAGACCCCAAACAGG       AAACAAAGTAAGAGTCAGACACTGGAGAAATCT TAA   GGATTTAAGACGTTCTTGTTACACTCCACCAA           CCTCACGAGTTTCTAACACCCAGGAACATGACCTCTAAAAACTGGATGAAAAAGGACACCCTGAGAAA           AGGTCCTAGCTGGAGTCAGTCCCCTCTGTGACCTCTCTCCTCAGGCCTCTAGAGGACAGATGGCCAGG           CCTGTGCACACACCAGCCCACCCTGAGAGACCCCTCTGGGACCAACCACCTGTGAGTCCTGCGATGCC           TTTAAGCAGCCTGTGCCCTCACCCAAGCTGCAGTTCCTGAAGGTGTAGTCTGTGTCTCTGCGGATGAC           ATGACAGCTCGCCATTCCCCGGAATCAGTGAGGCTGTCAGTCAGCCACGCTTCTGCAGTATGCAGAAA           CCTGTTCTTAGACTCCAAAGCCAGAGAAAGAATTCTCCCTTCGAGGCCCAACAAATTGAGAAGGAACT           GTGATGGACCACTTCCAAAACAGAGACGGGGGCAGGGGCTGAAGGGCAGAGACCAGGTGATGTCAGAA           GGAAAGCCGGGTTGCAGACACAGCCGCCCCTGCTCTGGTCCTCCAGCGTGTTTATGACGCTCGTGCAG           GTCGACGAGCCATCCTATGGACTAGTTAACACTAAGGTGGAGTTCAGACTTTTTTAGACAACGGCGCC           ACTGGCAGCCTTTCTCTATCAAGGGTCAGACGGTAAACGTTTTCAGCTTTGCAGACCAGAGGTCCCTC           TGGCTACAGTAGCGCAGACACAGCCACAGGCATGTCATTGAATGGCTGCGGCTATGTTCCAATAAAAA           CTTATTTACAATAACAGGTGGTGGCCAAATTGGCCCATGGGCCTTATTTGGTGAACCCTGTTCTATGA           GATCACCTAGGCTTCAGCCTTAAACAGTGGAAGCCATCCCCTGAATGACAAGTCACAAGGGTATCAAA           GAAAGACCCCTGAATTTTCATGGAAAAAGCTATTCAGACCCCTGCTTGGAAAGCTAAGGCACACTGCC           ACGAAGCAGCAAGGACGCCTTACAAGTCTCAGTGCAACAGAGATGGACACCTGGGCTGGGCTGGACAA           TGTTTAAGGTTCCTTTTAGTCCATGACTCAAGTGATACTGTTTTAGGCTATCAGGTAGTAAACACGAT           CTTAGACATCCCCATCTTTGTAAGCAGAACAGTACGGCACTTCACCACATCTGCTTCCCACCATGCTT           CTAAGCAGCTGTCTTCCCCCTGCTAATGTTACAACCAAAGCAGCCACCCCACCTCCTCTCGTGTTGAG           CCTCACGACCGCTGACCCAGCTGGAAAGCCAGCGCCCTGCCGCGTCACCCTGACTCTGCTCAGAGCCA           GCATTCCAGCCACAAAGAGGGCCTCCTTCCTTTCCTCTTTCATAAAAATGTTTTTTGAAGAGTTAGAG           TATATTTTAGGCTTTTTATCTTTATTAAAATTTCATGTGCATGTGTCTGTGTATTCTGCAATTTGTCA           TTTTCAGAAAGAAGGAACAGGCAATTCGAGAAGTTTCACCTGTACTCCCGAGCTGTTCCCCAGGCTCC           AGACCCACTTGAGAGCAGAAGGTGGAGCTCAATGAAGGGTCTCGAGCTCAGCGAAGGGTCACTGGGTG           AACTGAGAGAAACCACGTTCACAAACGCGTACTGCGGACTTCCTGCCGCCCTGGGACCTGTCACTGTT           TGTCCATGTAAGCTACAGCATTACTAGCAGATGCTAAGATCGAGTGATATCACTGGAAAAGTAGGTGA           ATCCTACTAGGAAACTTTCTACTCCCTACTAGGACCTCAAGCCCCTCAGCCACACAGCAAATGCTAAT           ATGCTCCAGTGTTAGCTTAGAAGCCTTGTGTCAACAAGAACTGGCTCCTGAGTCCCAAGCTTGGTGCC           ACACAGCAAATGCTAATATGCTCCAGTGTTAGCTTAGAAGCCTTGTGTCAACAAGAACTGGCTCCTGA           GTCCCAAGCTTGGTGCCACACAGCAAATGCTAATATGCTCCAGTGTTAGCTTAGAAGCCTTGTGTCAA           CAAGAACTGGCTCCTGAGTCCCAAGTGCTGTCACAGGACTTGCCCATTGGGATGTTTTCCACATTAAA           TATCAAGTAAAAAGACTTCCTGGTGCTCAGGAATTACAGTTCGTTCTTGAAACATTCCAAAGAGGCCA           CCACAGCTTTTCCCATGTGGCTTCTTTTAAAAACTCAAATGGCTTCCTTGAAAATACTCAAAGTCCAC           CCAAGGAAATTAGTAATAATAGAATCAGAAAACTGTCAGGAGCATAAAGATTTCTGTATCAAAATGAA           AGAAGCAATCCTGAGTTGCTGAATTACCCATCTGCTAATGAAACCGGGATGGACTGATCATCTAACCA           AGTGCAGACTGAGGATTCTACTTAGTCCTCCGACTGGGTACAACAACAGCCTAGGTTCTAGGGAGGGT           GGCAGTGACCGGGATGCCACAATGGAAGAGAAAATGAAAACACTGGCACAGTGAAATGTCTCATTTCC           AAACAGTTTTGCCTATGGCCAAGCAAGGCAATAAAGACAAACTCTCCCTTTTCCCCATTGCGTGTGGG           CTGCCAGGTACAAGTAAGGGAATCTTTGCTGTGCCCACTGTCCTCCAGTAGAGAACCCAACAGGCAAC           GGCCCCACTCAGGTATCAGCTCACCTCCTGCACCTCCCCTTAGCAGGAACTCCTTCCACTGGCAAAGG           ACTGCCACTGCCATCTGACTCAACTGTGGCGATGTGGACGGAGTCACCGAGCTGCTTTTCTTTTGCAA           AACAAAAGTCTTTTTCTTTGCAGTCACGCTGTAAGACGAGGCTGCTGGAGAAAACAAAAGCACCTAGA           TTTCAGTGCTGAATCCCCACAATTGCATGCAGCTCACACCTACCAGGGGTATTCCAGTGCATAGGGGA           AAGGAACCCGGCTGAAAAACCAGCTCCTTATTTTTCTTTTAAATAAAATAATACGATCCTAAGTCCAT           TTACCATCTGAAGTTGTCACGAGTGAACAGTCACATTACTGTTGTGGACCAGGCCTTAGATGAGTTTC           TCAGGCTCAGCACTGACATTCTGGGCCGGATCATCCTCTCTTGTGGGACCATCCTGTGCACTGCAGGA           TGTTTCACAGCACCCCTGGCCTCTACCCACTAGAATCCTACAATCTACCAGATCCTAGGATCTAGTTG           ATCCTAGAATGCTACCAAGGAGACTTGAATTTTGGTCCCATCATCAAAAATGCCTTCTGCATCAATCC           TATGCCAGTTTCCCCTAAAAGAGGGCTAACTGGAATGTTCTAGGATGTACCAATCCTCCAGGACCCTC           TTAGAGCTCATGCCATCAGAGACAGGCCTCTACCTCAGGGATCACCCCGGCTGACATCAAATTCCTCT           TCTCTTTTCCCAACATTTCAAATTGTTCTTCGGACTCATTGAGTTCC                                           NOV58e, CG93387-04   SEQ ID NO:1152   1288 aa   MW at 138836.0 kD           Protein Sequence                     MLRRATEDVRHYFPELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGKLSFTIFNYESIVW           TTGTHASSGGNATGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTNVGVPGRWAFRIDDAQVR       VGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHG       INSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPCL       NGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCR       ERVPDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHT       DHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGE       YHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNG       GTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIR       VCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGS       CRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFS       SPCGGRGYCLASNGSHSCTCKVGYTGEDCAKELFPPTALKMERVEESGVSISWNPPNGPAARQMLDGY       AVTYVSSDGSYRRTDFVDRTRSSHQLQALAAGRAYNISVFSVKRNSNNKNDISRPAVLLARTRPRPVE       GFEVTNVTASTISVQWALHRIREATVSGVRVSIRHPEALRDQATDVDRSVDRFTFRALLPGKRYTIQL       TTLSGLRGEEHPTESLATAPTHVWTRPLPPANLTAARVTATSAHVVWDAPTPGSLLEAYVINVTTSQS       TKSRYVPNGKLASYTVRDLLPGRRYQPSVIAVQSTELGPQHSEPAHLYIITSPRDGADRRWHQGGHHP       RVLKNRPPPARLPELRLLNDHSAPETPTQPPRFSEFVDGRGRVSARFGGSPSKAATVRSQPTASAQLE       NMEEAPKRVSPALQLPEHGSKDVGNVPGNCSENPCQNGGTCVPGADAHSCGCGPGFKGRRCELACIKV       SRPCTRLFSETKAFPVWEGGVCHHVYKRVYRVHQDICFKESCESTSLKKTPNRKQSKSQTLEKS                                     NOV58f, SNP13382519 of   SEQ ID NO:1153   5432 bp           CG93387-05, DNA Sequence   ORF Start: ATG at 187   ORF Stop: TAA at 3991           SNP Pos: 4223   SNP Change: C to T                       GGTGCCGAGCACTCCGGACTCTACGTGAACAACAACGGGATCATCTCCTTCCTGAAGGAGGTTTCTCA               GTTCACCCCAGTGGCCTTCCCCATTGCCAAGGACCGCTGCGTGGTGGCAGCCTTCTGGGCAGATGTGG           ACAACCGGCGTGCAGGCGACGTGTACTACCGGGAGGCCACCGACCCAGCC   ATG CTGCGCCGAGCCACG       GAGGACGTCAGGCACTACTTCCCCGAGCTCCTGGACTTCAATGCCACCTGGGTTTTTGTTGCCACCTG       GTACCGAGTGACCTTCTTTGGAGGCAGTTCCTCATCCCCTGTCAACACATTCCAGACTGTGCTCATCA       CAGACGGCAAGCTCTCCTTCACCATCTTCAACTATGAGTCCATCGTGTGGACCACAGGCACACACGCC       AGCAGCGGGGGCAACGCCACTGGCCTCGGGGGCATCGCAGCCCAGGCTGGCTTCAACGCAGGCGATGG       GCAGCGTTACTTCAGTATCCCCGGCTCGCGCACAGCAGACATGGCCGAGGTGGAGACCACCACCAACG       TGGGTGTGCCCGGGCGCTGGGCGTTCAGAATCGATGATGCCCAGGTGCGCGTGGGGGGCTGCGGCCAT       ACAACGTCCGTGTGCCTGGCCCTGCGCCCCTGCCTCAACGGCGGCAAGTGCATCGACGACTGCGTCAC       GGGCAACCCCTCCTACACCTGCTCCTGCCTCTCGGGCTTCACGGGGCGGAGGTGCCACCTGGACGTGA       ACGAATGTGCCTCCCAGCCCTGTCAGAATGGTGGGACCTGTACTCACGGCATCAACAGTTTCCGCTGC       CAGTGCCCGGCTGGCTTTGGGGGACCCACCTGTGAGACAGCCCAATCCCCCTGTGACACCAAAGAGTG       TCAACATGGTGGCCAGTGCCAGGTGGAGAACGGCTCTGCGGTGTGTGTGTGCCAGGCCGGATACACCG       GAGCAGCCTGCGAGATGGATGTGGACGACTGCAGCCCTGACCCCTGCCTGAATGGAGGCTCTTGTGTT       GACCTAGTGGGGAATTACACCTGCTTGTGTGCCGAGCCCTTCAAGGGACTTCGCTGTGAGACAGGAGA       CCATCCAGTGCCAGACGCCTGCCTCTCGGCCCCTTGCCACAATGGGGGCACCTGTGTGGATGCGGACC       AGGGCTACGTGTGCGAGTGCCCCGAAGGCTTCATGGGCCTGGACTGCAGGGAGAGAGTCCCCGATGAC       TGTGAGTGCCGCAACGGAGGCAGATGCCTGGGCGCCAACACCACCCTCTGCCAGTGCCCCCTGGGATT       CTTTGGGCTTCTCTGTGAATTTGAAATCACAGCCATGCCCTGCAACATGAACACACAGTGCCCAGATG       GGGGCTACTGCATGGAGCACGGCGGGAGCTACCTCTGCGTCTGCCACACCGACCACAATGCCAGCCAC       TCCCTGCCATCACCCTGCGACTCGGACCCCTGCTTCAACGGAGGCTCCTGCGATGCCCATGACGACTC       CTACACCTGCGAGTGCCCGCGCGGGTTCCACGGCAAGCACTGCGAGAAAGCCCGGCCACACCTGTGCA       GCTCAGGGCCCTGCCGGAACGGGGGCACGTGCAAGGAGGCGGGCGGCGAGTACCACTGCAGCTGCCCC       TACCGCTTCACTGGGAGGCACTGTGAGATCGGGAAGCCAGACTCGTGTGCCTCTGGCCCCTGTCACAA       CGGCGGCACCTGCTTCCACTACATTGGCAAATACAAGTGTGACTGTCCCCCAGGCTTCTCCGGGCGGC       ACTGCGAGATAGCCCCCTCCCCCTGCTTCCGGAGCCCGTGTGTGAATGGGGGCACCTGCGAGGACCGG       GACACGGATTTCTTCTGCCACTGCCAAGCAGGGTACATGGGACGCCGGTGCCAGGCAGAGGTGGACTG       CGGCCCCCCGGAGGAGGTGAAGCACGCCACACTGCGCTTCAACGGCACGCGGCTGGGCGCGGTGGCCC       TGTATGCATGTGACCGTGGCTACAGCCTGAGCGCCCCCAGCCGCATCCGGGTCTGCCAGCCACACGGT       GTCTGGAGTGAGCCTCCCCAGTGCCTTGAAATCGATGAGTGCCGGTCTCAGCCGTGCCTGCATGGGGG       CTCTTGTCAGGACCGCGTTGCTGGGTACCTGTGCCTCTGCAGCACAGGCTATGAGGGCGCCCACTGTG       AGCTGGAGAGGGATGAGTGCCGAGCTCACCCGTGCAGAAATGGAGGGTCCTGCAGGAACCTCCCAGGG       GCCTATGTCTGCCGGTGCCCTGCAGGCTTCGTTGGAGTCCACTGTGAGACAGAGGTGGACGCCTGCGA       CTCCAGCCCCTGCCAGCATGGAGGCCGGTGTGAGAGCGGCGGCGGGGCCTACCTGTGCGTCTGCCCAG       AGAGCTTCTTCGGCTACCACTGCGAGACAGTGAGTGACCCCTGCTTCTCCAGCCCCTGTGGGGGCCGT       GGCTATTGCCTGGCCAGCAACGGCTCCCACAGCTGCACCTGCAAAGTGGGCTACACGGGCGAGGACTG       CGCCAAAGAGCTCTTCCCACCGACGGCCCTCAAGATGGAGAGAGTGGAGGAGAGTGGGGTCTCTATCT       CCTGGAACCCGCCCAATGGTCCAGCCGCCAGGCAGATGCTTGATGGCTACGCGGTCACCTACGTCTCC       TCCGACGGCTCCTACCGCCGCACAGACTTTGTGGACAGGACCCGCTCCTCGCACCAGCTCCAGGCCCT       GGCGGCCGGCAGGGCCTACAACATCTCCGTCTTCTCAGTGAAGCGAAACAGTAACAACAAGAATGACA       TCAGCAGGCCTGCCGTGCTGCTGGCCCGCACGCGACCCCGCCCTGTGGAAGGCTTCGAGGTCACCAAT       GTGACGGCTAGCACCATCTCAGTGCAGTGGGCCCTGCACAGGATCCGCCATGCCACCGTCAGTGGGGT       CCGTGTGTCCATCCGCCACCCTGAGGCCCTCAGGGACCAGGCCACCGATGTGGACAGGAGTGTGGACA       GGTTCACCTTTAGGGCCCTGCTGCCTGGGAAGAGGTACACCATCCAGCTGACCACCCTCAGTGGGCTC       AGGGGAGAGGAGCACCCCACAGAGAGCCTGGCCACCGCGCCGACGCACGTGTGGACCCGGCCCCTGCC       TCCAGCAAACCTGACCGCCGCCCGAGTCACTGCCACCTCTGCCCACGTGGTCTGGGATGCCCCGACTC       CAGGCAGCTTGCTGGAGGCTTATGTCATCAATGTGACCACCAGCCAGAGCACCAAGAGCCGCTATGTC       CCCAACGGGAAGCTGGCGTCCTACACGGTGCGCGACCTGCTGCCGGGACGGCGGTACCAGCCCTCTGT       GATAGCAGTGCAGAGCACGGAGCTCGGGCCGCAGCAGCACCAGGGAGGACACCACCCTCGGGTGCTCA       AGAACAGACCGCCCCCGGCGCGCCTGCCGGAGCTGCGCCTGCTCAATGACCACAGCGCCCCCGAGACC       CCCACCCAGCCCCCCAGGTTCTCGGAGTTTGTGGACGGCAGAGGAAGAGTGAGCGCCAGGTTCGGTGG       CTCACCCAGCAAAGCAGCCACCGTGAGATCACAACCCACAGCCTCGGCGCAGCTCGAGAACATGGAGG       AAGCCCCCAAGCGGGTCAGCCCGGCCCTCCAGCTCCCTGAACACGGCAGCAAGGACATCGGAAACGTC       CCTGGCAACTGTTCAGAAAACCCCTGTCAGAACGGAGGCACTTGTGTGCCGGGCGCAGACGCCCACAG       CTGTGACTGCGGGCCAGGGTTCAAAGGCAGACGCTGCGAGCTCGCCTGTATAAAGGTGTCCCGCCCCT       GCACAAGGCTGTTCTCCGAGACAAAGGCCTTTCCAGTCTGGGAGGGAGGCGTCTGTCACCACGTGTAT       AAAAGAGTCTACCGAGTTCACCAAGACATCTGCTTCAAAGAGAGCTGTGAAAGCACAAGCCTCAAGAA       GACCCCAAACAGGAAACAAAGTAAGAGTCAGACACTGGAGAAATCT TAA   GGATTTAAGACGTTCTTGT           TACACTCCACCAACCTCACGAGTTTCTAACACCCAGGAAGATGAGGTCTAAAAACTGGATGAAAAAGC           ACACCCTGAGAAAAGGTCCTAGCTGGAGTCAGTCCCCTCTGTGACCTCTCTCCTCAGGCCTCTAGAGC           ACAGATGGCCAGGCCTGTGCACACACCAGCCCACCCTGAGAGACCCCTCTGGGACCAACCACCTGTGA           GTCCTGTGATGCGTTTAAGCAGCCTGTGCCCTCACCCAAGCTGCAGTTCCTGAAGGTGTAGTCTGTGT           CTCTGCGGATGAGATGACAGCTCGCCATTCCCCGGAATCAGTGAGGCTGTCAGTCAGCCACGCTTCTG           CAGTATGCAGAAACCTGTTCTTAGACTCCAAAGCCAGAGAAAGAATTCTCCCTTCGAGGCCCAACAAA           TTGAGAAGGAACTGTGATGGACCACTTCCAAAACAGAGACGGGGGCAGGGGCTGAAGGGCAGAGACCA           GGTGATGTCAGAAGGAAAGCCGGGTTGCAGACACAGCCGCCCCTGCTCTGGTCCTCCAGCGTGTTTAT           GACGCTCGTGCAGGTCGACGAGCCATCCTATGGACTAGTTAACACTAAGGTGGAGTTCAGACTTTTTT           AGACAACGGCGCGACTGGCAGCCTTTCTCTATCAAGGGTCAGACGGTAAACGTTTTCAGCTTTGCAGA           CCAGAGGTCCCTGTGGCTACAGTAGCGCAGACACAGCCACAGGCATGTCATTGAATGGCTGCGGCTAT           GTTCCAATAAAAACTTATTTACAATAACAGGTGGTGGCCAAATTGGCCCATGGGCCTTATTTGGTGAA           CCCTGTTCTATGAGATCACCTAGGCTTCAGCCTTAAACAGTGGAAGCCATCCCCTGAATGACAAGTCA           CAAGGGTATCAAAGAAAGACCCCTGAATTTTCATGGAAAAAGCTATTCAGACCCCTGCTTGGAAAGCT           AAGGCACACTGCCACGAAGCAGCAAGGACGCCTTACAAGTCTCAGTGCAACAGAGATGGACACCTGGG           CTGGGCTGGACAATGTTTAAGGTTCCTTTTAGTCCATGACTCAAGTGATACTGTTTTAGGCTATCAGG           TAGTAAACACGATCTTAGACATCCCCATCTTTGTAAGCAGAACAGTACGGCACTTCACCACATCTGCT           TCCCACCATGCTTCTAAGCAGCTGTCTTCCCCCTGCTAATGTTACAACCAAAGCAGCCACCCCACCTC           CTCTCGTGTTGAGCCTCACGACCGCTGACCCAGCTGGAAAGCCAGCGCCCTGCCGCGTCACCCTGACT           CTGCTCAGAGCCAGCATTCCAGCCACAAAGAGGGCCTCCTTCCTTTCCTCTTTCATAAAAATGTTTTT           TGAAGAGTTAGAGTATATTTTAGGCTTTTTATCTTTATTAAAATTTCATGTGCATGTGTA                                           NOV58f, SNP13382519 of   SEQ ID NO:1154   1268 aa   MW at 136576.5 kD           CG93387-05, Protein Sequence           SNP Change: no change                     MLRRATEDVRHYFPELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGKLSFTIFNYESIVW           TTGTHASSGGNATGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTNVGVPGRWAFRIDDAQVR       VGGCGHTTSVCIALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHG       INSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPCL       NGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCR       ERVPDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHT       DHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGE       YHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNG       GTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIR       VCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGS       CRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFS       SPCGGRGYCLASNGSHSCTCKVGYTGEDCAKELFPPTALKMERVEESGVSISWNPPNGPAARQMLDGY       AVTYVSSDGSYRRTDFVDRTRSSHQLQALAAGRAYNISVFSVKRNSNNKNDISRPAVLLARTRPRPVE       GFEVTNVTASTISVQWALHRIRHATVSGVRVSIRHPEALRDQATDVDRSVDRFTFHALLPGKRYTIQL       TTLSGLRGEEHPTESLATAPTHVWTRPLPPANLTAARVTATSAHVVWDAPTPGSLLEAYVINVTTSQS       TKSRYVPNGKLASYTVRDLLPGRRYQPSVIAVQSTELGPQQHQGGHHPRVLKNRPPPARLPELRLLND       HSAPETPTQPPRFSEFVDGRGRVSARFGGSPSKAATVRSQPTASAQLENMEEAPKRVSPALQLPEHGS       KDIGNVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGG       VCHHVYKRVYRVHQDICFKESCESTSLKKTPNRKQSKSQTLEKS                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 58B.  
               TABLE 58B                       Comparison of the NOV58 protein sequences.                                                NOV58a   MLRRATEDVRHYFPELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGKLSFTI   (SEQ ID NO:1144)                   NOV58b   MLRRATEDVRHYFPELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGKLSFTI   (SEQ ID NO:1146)               NOV58c   MLRRATEDVRHYFPELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGKLSFTI   (SEQ ID NO:1148)               NOV58d   ------------------------------------------------------------   (SEQ ID NO:1150)               NOV58e   MLRRATEDVRHYFPELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGKLSFTI   (SEQ ID NO:1152)               NOV58a   FNYESIVWTTGTHASSGGNATGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTNV               NOV58b   FNYESIVWTTGTHASSGGNATGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTNV               NOV58c   FNYESIVWTTGTHASSGGNATGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTIV               NOV58d   ------------------------------------------------------------               NOV58e   FNYESIVWTTGTHASSGGNATGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVETTTNV               NOV58a   GVPGRWAFRIDDAQVRVGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTG               NOV58b   GVPGRWAFRIDDAQVRVGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTG               NOV58c   VVPGRWAFIIDDAQVRVGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTG               NOV58d   ------------------------------------------------------------               NOV58e   GVPGRWAFRIDDAQVRVGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTG               NOV58a   RRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQ               NOV58b   RRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQ               NOV58c   RRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQ               NOV58d   ------------------------------------------------------------               NOV58e   RRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQ               NOV58a   VENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETG               NOV58b   VENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETG               NOV58c   VENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETG               NOV58d   ------------------------------------------------------------               NOV58e   VENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETG               NOV58a   DNPVPDACLSAPCHNGGTCVDADQGYVCE-CPEGFMGLDCRERVPDDCECRNGGRCLGAN               NOV58b   DHPVPDACLSAPCHNGGTCVDADQGYVCE-CPEGFMGLDCRERVPDDCECRNGGRCLGAN               NOV58c   DHXQCQTPASRPLATMGAPVWMRTRATCASAPKASWAWTAGRESPMTVSAATEADAWAPT               NOV58d   -----------------------------------MGLDCRERVPDDCECRNGGRCLGAN               NOV58e   DHPVPDACLSAPCHNGGTCVDADQGYVCE-CPEGFMGLDCRERVPDDCECRNGGRCLGAN               NOV58a   TTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSP               NOV58b   TTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSP               NOV58c   PPSAQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSP               NOV58d   TTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSP               NOV58e   TTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSP               NOV58a   CDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHC               NOV58b   CDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHC               NOV58c   CDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHC               NOV58d   CDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHC               NOV58e   CDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHC               NOV58a   SCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRS               NOV58b   SCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRS               NOV58c   SCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRS               NOV58d   SCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRS               NOV58e   SCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRS               NOV58a   PCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYAC               NOV58b   PCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYAC               NOV58c   PCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYAC               NOV58d   PCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYAC               NOV58e   PCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYAC               NOV58a   DRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYE               NOV58b   DRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYE               NOV58c   DRGYSLSAPSRIRVCQPHGVWK-------IDECRSQPCLHGGSCQDRVAGYLCLCSTGYE               NOV58d   DRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYE               NOV58e   DRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYE               NOV58a   GAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRC               NOV58b   GAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRC               NOV58c   GAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRC               NOV58d   GAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRC               NOV58e   GAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRC               NOV58a   ESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAK               NOV58b   ESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAK               NOV58c   ESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAK               NOV58d   ESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAK               NOV58e   ESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAK               NOV58a   ELFPPTALKMERVEESGVSISWNPPNGPAARQMLDGYAVTYVSSDGSYRRTDFVDRTRSS               NOV58b   ELFPPTALKMERVEESGVSISWNPPNGPAARQMLDGYAVTYVSSDGSYRRTDFVDRTRSS               NOV58c   ELFPPTALKMERVEESGVSISWNPPNGPAARQMLDGYAVTYVSSDGSYRRTDFVDRTRSS               NOV58d   ELFPPTALKMERVEESGVSISWNPPNGPAARQMLDGYAVTYVSSDGSYRRTDFVDRTRSS               NOV58e   ELFPPTALKMERVEESGVSISWNPPNGPAARQMLDGYAVTYVSSDGSYRRTDFVDRTRSS               NOV58a   HQLQALAAGRAYNISVFSVKRNSNNKNDISRPAVLLARTRPRPVEGFEVTNVTASTISVQ               NOV58b   HQLQALAAGRAYNISVFSVKRNSNNKNDISRPAVLLARTRPRPVEGFEVTNVTASTISVQ               NOV58c   HQLQALAAGRAYNISVFSVKRNSNNKNDISRPAVLLARTRPRPVEGFEVTNVTASTISVQ               NOV58d   HQLQALAAGRAYNISVFSVKRNSNNKNDISRPAVLLARTRPRPVEGFEVTNVTASTISVQ               NOV58e   HQLQALAAGRAYNISVFSVKRNSNNKNDISRPAVLLARTRPRPVEGFEVTNVTASTISVQ               NOV58a   WALHRIRHATVSGVRVSIRHPEALRDQATDVDRSVDRFTFRALLPGKRYTIQLTTLSGLR               NOV58b   WALHRIRHATVSGVRVSIRHPEALRDQATDVDRSVDRFTFRALLPGKRYTIQLTTLSGLR               NOV58c   WALHRIRHATVSGVRVSIRHPFALRDQATDVDRSVDRFTFPALLPGKRYTIQLTTLSGLR               NOV58d   WALHRIRHATVSGVRVSIRHPEALRDQATDVDRSVDRFTFRALLPGKRYTIQLTTLSGLR               NOV58e   WALHRIRHATVSGVRVSIRHPEALRDQATDVDRSVDRFTFRALLPGKRYTIQLTTLSGLR               NOV58a   GEEHPTESLATAPTHVWTRPLPPANLTAARVTATSAHVVWDAPTPGSLLEAYVINVTTSQ               NOV58b   GEEHPTESLATAPTHVWTRPLPPANLTAARVTATSAHVVWDAPTPGSLLEAYVINVTTSQ               NOV58c   GEEHPTESLATAPTHVWTRPLPPANLTAARVTATSAHVVWDAPTPGSLLEAYVINVTTSQ               NOV58d   GEEHPTESLATAPTHVWTRPLPPANLTAARVTATSAHVVWDAPTPGSLLEAYVINVTTSQ               NOV58e   GEEHPTESLATAPTHVWTRPLPPANLTAARVTATSAHVVWDAPTPGSLLEAYVINVTTSQ               NOV58a   STKSRYVPNGKLASYTVRDLLPGRRYQPSVIAVQSTELGPQQ------------------               NOV58b   STKSRYVPNGKLASYTVRDLLPGRRYQPSVIAVQSTELGPQHSEPAHLYIITSPRDGADR               NOV58c   STKSRYVPNGKLASYTVRDLLPGRRYQLSVIAVQSTELGPQHSEPAHLYIITSPRDGADR               NOV58d   STKSRYVPNGKLASYTVRDLLPGRRYQPSVIAVQSTELGPQHSEPAHLYIITSPRDGADR               NOV58e   STKSRYVPNGKLASYTVRDLLPGRRYQPSVIAVQSTELGPQHSEPAHLYIITSPRDGADR               NOV58a   --HQGGHHPRVLKNRPPPARLPELRLLNDHSAPETPTQPPRFSEFVDGRGRVSARFGGSP               NOV58b   RWHQGGHHPRVLKNRPPPARLPELRLLNDHSAPETPTQPPRFSEFVDGRGRVSARFGGSP               NOV58c   RWHQGGHHPRVLKNRPPPARLPELRLLNDHSAPETPTQPPRFSELVDGRGRVSARFGGSP               NOV58d   RWHQGGHHPRVLKNRPPPARLPELRLLNDHSAPETPTQPPRFSEFVDGRGRVSARFGGSP               NOV58e   RWHQGGHHPRVLKNRPPPARLPELRLLNDHSAPETPTQPPRFSEFVDGRGRVSARFGGSP               NOV58a   SKAATVRS----------------------------------------------------               NOV58b   SKAATVRS----------------------------------------------------               NOV58c   SKAATVRSRPVPYMMSPPPPPAQSPASDPHPDCAQGAGLVGRRQHAPPWQEGQLGHPCSL               NOV58d   SKAATVRS----------------------------------------------------               NOV58e   SKAATVRS----------------------------------------------------               NOV58a   -----------------------------QPTASAQLENMEEAPKRVSPALQLPEHGSKD               NOV58b   -----------------------------QPTASAQLENMEEAPKRVSPALQLPEHGSKD               NOV58c   RYRSTQKGGPRTIPGAKQLRRVVTAWLLLEPTASAQLENMEEAPKRVSLALQLPEHGSKD               NOV58d   -----------------------------QPTASAQLENMEEAPKRVSPALQLPEHGSKD               NOV5Be   -----------------------------QPTASAQLENMEEAPKRVSPALQLPEHGSKD               NOV58a   IG----------------------------------------------------------               NOV58b   IG----------------------------------------------------------               NOV58c   IGSYAGPELSPSPGLCLVRIEASTSLQGTKHLLSTCSTQAKEQGGAFTLPCLCGPVQGDH               NOV58d   IG----------------------------------------------------------               NOV58e   VG----------------------------------------------------------               NOV58a   ---------------NVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVS               NOV58b   ---------------NVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVS               NOV58c   GVGEGKPVFTDHSPADVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELG-IKES               NOV58d   ---------------NVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVS               NOV58e   ---------------NVPGNCSENPCQNGGTCVPGADAHSCGCGPGFKGRRCELACIKVS               NOV58a   RPCTRLFSETKAFPVWEGGVCHHVYKRVYRVHQDICFKESCESTSLKKTPNPKQSKSQTL               NOV58b   RPCTRLFSETKAFPVWEGGVCHHVYKRVYRVHQDICFKESCESTSLKKTPNRKQSKSQTL               NOV5Bc   TEFTKTSASKRAVKAQAS-----------RRPQTGASGEQAHAVSCM-------------               NOV58d   RPCTRLFSETKAFPVWEGGVCHHVYKRVYRVHQDICFKESCESTSLKKTPNPKQSKSQTL               NOV58e   RPCTRLFSETKAFPVWEGGVCHHVYKRVYRVHQDICFKESCESTSLKKTPNRKQSKSQTL               NOV58a   EKS               NOV58b   EKS               NOV58c   ---               NOV58d   EKS               NOV58e   EKS                  
 
      Further analysis of the NOV58a protein yielded the following properties shown in Table 58C.  
               TABLE 58C                       Protein Sequence Properties NOV58a                                        SignalP analysis:   Cleavage site between residues 41 and 42       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 10; pos. chg 3; neg. chg 2           H-region:   length 4; peak value −6.27           PSG score:   −10.68                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −3.98           possible cleavage site: between 40 and 41                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 0           number of TMS(s) . . . fixed                             PERIPHERAL   Likelihood = 2.12 (at 365)                         ALOM score: 2.12 (number of TMSs: 0)       MITDISC:   discrimination of mitochondrial targeting seq                                     R content:    2   Hyd Moment(75):   18.26           Hyd Moment(95):   17.56   G content:    0           D/E content:    2   S/T content:    1                         Score: −1.90       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 14 RRA|TE                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: PGFKGRR (3) at 1190           bipartite: none           content of basic residues: 9.5%           NLS Score: −0.22       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: LRRA           KKXX-like motif in the C-terminus: TLEK                 SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear           discrimination           Prediction: nuclear           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         52.2%: nuclear           34.8%: mitochondrial            8.7%: cytoplasmic            4.3%: cytoskeletal                 &gt;&gt; prediction for CG93387-05 is nuc (k = 23)                  
 
      A search of the NOV58a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 58D.  
               TABLE 58D                          Geneseq Results for NOV58a                                         NOV58a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #,Date]   Residues   Region   Value                                             AAB82249   Human insulin-responsive sequence   261 . . . 1268    1004/1028   (97%)   0.0           DNA binding protein-1 -  Homo     1 . . . 1028   1004/1028   (97%)             sapiens , 1028 aa. [WO200132873-A1,           10-MAY-2001]       AAB82247   Rat insulin-responsive sequence DNA   271 . . . 1253    797/1003   (79%)   0.0           binding protein-1 -  Rattus  sp, 1008 aa.   1 . . . 1002   876/1003   (86%)           [WO200132873-A1, 10-MAY-2001]       AAB42900   Human ORFX ORF2664 polypeptide   1 . . . 627    592/629   (94%)   0.0           sequence SEQ ID NO: 5328 -  Homo     61 . . . 689    593/629   (94%)             sapiens , 694 aa. [WO200058473-A2,           05-OCT-2000]       AAB82251   Rat insulin-responsive sequence DNA   780 . . . 1253    368/494   (74%)   0.0           binding protein-1 (truncated) -  Rattus     1 . . . 493    414/494   (83%)           sp, 499 aa. [WO200132873-A1, 10-           MAY-2001]       AAB82250   Human insulin-responsive sequence   813 . . . 1161    344/369   (93%)   0.0           DNA binding protein-1 (variant) -  Homo     1 . . . 369    345/369   (93%)             sapiens , 387 aa. [WO200132873-A1,           10-MAY-2001]                  
 
      In a BLAST search of public sequence databases, the NOV58a protein was found to have homology to the proteins shown in the BLASTP data in Table 58E.  
               TABLE 58E                          Public BLASTP Results for NOV58a                                         NOV58a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             Q8TER0   FLJ00133 protein -  Homo sapiens      7 . . . 1268   1258/1282   (98%)   0.0           (Human), 1282 aa (fragment).    1 . . . 1282   1258/1282   (98%)       AAO41836   Secreted protein SST3 -  Mus      1 . . . 939   800/939   (85%)   0.0             musculus  (Mouse), 1065 aa.   126 . . . 1064   862/939   (91%)       Q8N369   Hypothetical protein -  Homo sapiens     666 . . . 1252   549/607   (90%)   0.0           (Human), 600 aa.   26 . . . 599   551/607   (90%)       Q8TEP7   FLJ00146 protein -  Homo sapiens     706 . . . 1268   498/583   (85%)   0.0           (Human), 522 aa (fragment).    1 . . . 522   499/583   (85%)       P10079   Fibropellin I precursor (Epidermal   140 . . . 777    261/679   (38%)   e−145           growth factor-related protein 1)   249 . . . 895    339/679   (49%)           (UEGF-1) -  Strongylocentrotus               purpuratus  (Purple sea urchin), 1064           aa.                  
 
      PFam analysis predicts that the NOV58a protein contains the domains shown in the Table 58F.  
               TABLE 58F                          Domain Analysis of NOV58a                                             Identities/                       Similarities for           Pfam   NOV58a   the Matched   Expect           Domain   Match Region   Region   Value                       EGF   147 . . . 183   16/47 (34%)   3.4e−05                   28/47 (60%)           EGF   190 . . . 221   15/47 (32%)   6.9e−08                   28/47 (60%)           EGF   228 . . . 259   13/47 (28%)   1.4e−05                   21/47 (45%)           EGF   266 . . . 297   17/47 (36%)   1.5e−09                   26/47 (55%)           EGF   308 . . . 339   18/47 (38%)   2.9e−09                   25/47 (53%)           EGF   420 . . . 451   17/47 (36%)   4.3e−07                   25/47 (53%)           EGF   459 . . . 490   16/47 (34%)   1.5e−05                   26/47 (55%)           EGF   498 . . . 529   18/47 (38%)   4.9e−09                   29/47 (62%)           EGF   536 . . . 567   15/47 (32%)   4.7e−06                   22/47 (47%)           sushi   573 . . . 626   16/64 (25%)   3.8e−05                   36/64 (56%)           EGF   632 . . . 663   14/47 (30%)   7.8e−07                   21/47 (45%)           EGF   670 . . . 701   17/47 (36%)   3.3e−07                   23/47 (49%)           EGF   708 . . . 739   13/47 (28%)   1.4e−05                   25/47 (53%)           EGF   746 . . . 777   13/47 (28%)   3.5e−05                   26/47 (55%)           fn3   781 . . . 862   24/88 (27%)   3.9e−08                   60/88 (68%)           fn3   880 . . . 963   18/87 (21%)     2e−09                   62/87 (71%)           fn3    979 . . . 1061   27/86 (31%)   9.3e−08                   58/86 (67%)           EGF   1166 . . . 1197   17/47 (36%)   4.2e−08                   28/47 (60%)                      
 
     Example 59  
      The NOV59 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 59A.  
               TABLE 59A                       NOV59 Sequence Analysis                                                        NOV59a, CG93871-01   SEQ ID NO: 1155   2018 bp               DNA Sequence   ORF Start: ATG at 101   ORF Stop: TAA at 1937                       CTCCCCACGGCGCCAGGAGGAGGGGCGAGGGCCGGCAGCCCCCTCTCCCGCGCGCGGCGCAGGAGCCC               AGCCCAGCCCGGGGGACCCGCCGCCGCCGGTC   ATG TGGGCCGGACTGCTCCTTCGGGCCGCCTGTGTC       GCGCTCCTGCTGCCGGGGGCACCAGCCCGAGGCTACACCGGGAGGAAGCCGCCCGGGCACTTCGCGGC       CGAGAGGCGCCGACTGGGCCCCCACGTCTGCCTCTCTGGGTTTGGGAGTGGCTGCTGCCCTGGCTGGG       CGCCCTCTATGGGTGGTGGGCACTGCACCCTGCGTCTCTGCTCCTTCGGCTGTGGGAGTGGCATCTGC       ATCGCTCCCAATGTCTGCTCCTGCCAGGATGGAGAGCAAGGGGCCACCTGCCCAGAAACCCATGGACC       ATGTGGGGAGTACGGCTGTGACCTTACCTGCAACCATGGAGGCTGTCAGGAGGTGGCCCGAGTGTGCC       CCGTGGGCTTCTCGATGACGGAGACAGCTGTTGGCATCAGGTGTGACATTGACGAATGTGTAACCTCC       TCCTGCGAGGGCCACTGTGTGAACACAGAAGGTGGGTTTGTGTGCGAGTGTGGGCCGGGCATGCAGCT       GTCTGCCGACCGCCACAGCTGCCAAGACACTGACGAATGCCTAGGGACTCCCTGTCAGCAGAGATGTA       AAAACAGCATTGGCAGCTACAAGTGTTCCTGTCGAACTGGCTTCCACCTTCATGGCAACCGGCACTCC       TGTGTAGATGTAAACGAGTGTCGGAGGCCATTGGAGAGGCGAGTCTGTCACCATTCCTGCCACAACAC       CGTGGGCAGCTTCCTATGCACATGCCGACCTGGCTTCAGGCTCCGAGCTGACCGCGTGTCCTGTGAAG       CTTTCCCGAAAGCCGTGCTGGCCCCATCTGCCATCCTGCAACCCCGGCAACACCCGTCCAAGATGCTT       CTGTTGCTTCCTGAGGCCGGCCGGCCTGCCCTGTCCCCAGGACATAGCCCTCCTTCTGGGGCTCCAGG       GCCCCCAGCCGGAGTCAGGACCACCCGCCTGCCATCTCCCACCCCACGACTACCCACATCCTCCCCTT       CTGCCCCTGTGTGGCTGCTGTCCACCCTGCTGGCCACCCCAGTGCCTACTGCCTCCCTGCTGGGGAAC       CTCAGACCCCCCTCACTCCTTCAGGGGGAGGTGATGGGGACCCCTTCCTCACCCAGGGGCCCTGAGTC       CCCCCGACTGGCAGCAGGGCCCTCTCCCTGCTGGCACCTGGGAGCCATGCATGAATCAAGGAGTCGCT       GGACAGAGCCTGGGTGTTCCCAGTGCTGGTGCGAGGATGGGAAGGTGACCTGTGAAAAGGTGAGGTGT       GAAGCTGCTTGTTCCCACCCAATTCCCTCCAGAGATGGTGGGTGCTGCCCATCGTGCACAGGTTGTTT       TCACAGTGGTGTCGTCCGAGCTGAAGGGGATGTGTTTTCACCTCCCAATGAGAACTGCACCGTCTGTG       TCTGTCTGGCTGGAAACGTGTCGTGCATGTTTCGTGAGTGTCCTTTTGGCCCGTGTGAGACCCCCCAT       AAAGACAGATGCTATTTCCACGGCCGGTGGTACGCAGACGGGGCTGTGTTCAGTGGGGGTGGTGACGA       GTGTACCACCTGTGTTTGCCAGAATGGGGAGGTGGAGTGCTCCTTCATGCCCTGCCCTGAGCTGGCCT       GCCCCCGAGAAGAGTGGCGGCTGGGCCCTGGGCAGTGTTGCTTCACCTGCCAGGAGCCCACACCCTCG       ACAGGTTGCTCTCTTGACGACAACGGGGTTGAGTTTCCGATTGGACAGATCTGGTCGCCTGGTGACCC       CTGTAGATGGCTCGGTGAGCTGCAAGAGGACAGACTGTGTGGACTCCTGCCCTCACCCGATCCGGATC       CCTGGACAGTGCTGCCCAGACTGTTCAGCAGG TAA   TCCCCTGCCTCTGCCCCAAGCCCCCAGGGCAGG           GCATCTCAGGCATCGGGCTCCTTAAGCCCTATACAGCCTTCATCTC                                                   NOV59a, CG93871-01   SEQ ID NO: 1156   612 aa   MW at 65156.4kD               Protein Sequence                     MWAGLLLRAACVALLLPGAPARGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHCTL           RLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAV       GIRCDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSC       RTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSA       ILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLL       ATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWC       EDGKVTCEKVRCEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCMF       RECPFGPCETPHKDRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPG       QCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCRWLGELQEDRLCGLLPSPDPDPWTVLPRLFSR                                             NOV59b, CG93871-05   SEQ ID NO: 1157   2819 bp               DNA Sequence   ORF Start: ATG at 5   ORF Stop: TAA at 2807                       GGTC   ATG TGGGCCGGACTGCTCCTTCGGGCCGCCTGTGTCGCGCTCCTGCTGCCGGGGGCACCAGCCC           GAGGCTACACCGGGAGGAAGCCGCCCGGGCACTTCGCGGCCGAGAGACGCCGACTGGGCCCCCACGTC       TGCCTCTCTGGGTTTGGGAGTGGCTGCTGCCCTGGCTGGGCGCCCTCTATGGGTGGTGGGCACTGCAC       CCTGCCCCTCTGCTCCCTCGGCTGTGGGAGTGGCATCTGCATCGCTCCCAATGTCTGCTCCTGCCAGG       ATGGAGAGCAAGGGGCCACCTGCCCAGAAACCCATGGACCATGTGGGGAGTACGGCTGTGACCTTACC       TGCAACCATGGAGGCTGTCAGGAGGTGGCCCGAGTGTGCCCCGTGGGCTTCTCGATGACGGAGACAGC       TGTTGGCATCAGGTGTACAGACATTGACGAATGTGTAACCTCCTCCTGCGAGGGCCACTGTGTGAACA       CAGAAGACACTGACGAATGCCTAGGGACTCCCTGTCAGCAGAGATGTAAAAACAGCATTGGCAGCTAC       AAGTGTTCCTGTCGAACTGGCTTCCACCTTCATGGCAACCGGCACTCCTGTGTAGATGTAAACGAGTG       TCGGAGGCCATTGGAGAGGCGAGTCTGTCACCATTCCTGCCACAACACCGTGGGCAGCTTCCTATGCA       CATGCCGACCTGGCTTCAGGCTCCGAGCTGACCGCGTGTCCTGTGAAGCTTTCCCGAAAGCCGTGCTG       GCCCCATCTGCCATCCTGCAACCCCGGCAACACCCGTCCAAGATGCTTCTGTTGCTTCCTGAGGCCGG       CCGGCCTGCCCTGTCCCCAGGACATAGCCCTCCTTCTGGGGCTCCAGGGCCCCCAGCCGGAGTCAGGA       CCACCCGCCTGCCATCTCCCACCCCACGACTACCCACATCCTCCCCTTCTGCCCCTGTGTGGCTGCTG       TCCACCCTGCTGGCCACCCCAGTGCCTACTGCCTCCCTGCTGGGGAACCTCAGACCCCCCTCACTCCT       TCAGGGGGAGGTGATGGGGACCCCTTCCTCACCCAGGGGCCCTGAGTCCCCCCGACTGGCAGCAGGGC       CCTCTCCCTGCTGGCACCTGGGAGCCATGCATGAATCAAGGAGTCGCTGGACAGAGCCTGGGTGTTCC       CAGTGCTGGTGCGAGGACGGGAAGGTGACCTGTGAAAAGGTGAGGTGTGAAGCTGCTTGTTCCCACCC       AATTCCCTCCAGAGATGGTGGGTGCTGCCCATCGTGCACAGGCTGTTTTCACAGTGGTGTCGTCCGAG       CTGAAGGGGATGTGTTTTCACCTCCCAATGAGAACTGCACCGTCTGTGTCTGTCTGGCTGGAAACGTG       TCCTGCATCTCTCCTGAGTGTCCTTCTGGCCCCTGTCAGACCCCCCCACAGACGGATTGCTGTACTTG       TGTTCCAGTGAGATGCTATTTCCACGGCCGGTGGTACGCAGACGGGGCTGTGTTCAGTGGGGGTGGTG       ACGAGTGTACCACCTGTGTTTGCCAGAATGGGGAGGTGGAGTGCTCCTTCATGCCCTGCCCTGAGCTG       GCCTGCCCCCGAGAAGAGTGGCGGCTGGGCCCTGGGCAGTGTTGCTTCACCTGCCAGGAGCCCACACC       CTCGACAGGCTGCTCTCTTGACGACAACGGGGTTGAGTTTCCGATTGGACAGATCTGGTCGCCTGGTG       ACCCCTGTGAGTTATGCATCTGCCAGGCAGATGGCTCGGTGAGCTGCAAGAGGACAGACTGTGTGGAC       TCCTGCCCTCACCCGATCCGGATCCCTGGACAGTGCTGCCCAGACTGTTCAGCAGGCTGCACCTACAC       AGGCAGAATCTTCTATAACAACGAGACCTTCCCGTCTGTGCTGGACCCATGTCTGAGCTGCATCTGCC       TGCTGGGCTCAGTGGCCTGTTCCCCCGTGGACTGCCCCATCACCTGTACCTACCCTTTCCACCCTGAC       GGGGAGTGCTGCCCCGTGTGCCGAGACTGCAACTACGAGGGAAGGAAGGTGGCGAATGGCCAGGTGTT       CACCTTGGATGATGAACCCTGCACCCGGTGCACGTGCCAGCTGGGAGAGGTGAGCTGTGAGAAGGTTC       CCTGCCAGCGGGCCTGTGCCGACCCTGCCCTGCTTCCTGGGGACTGCTGCTCTTCCTGTCCAGATTCC       CTGTCTCCTCTGGAAGAAAAGCAGGGGCTCTCCCCTCACGGAAATGTGGCATTCAGCAAAGCTGGTCG       GAGCCTGCATGGAGACACTGAGGCCCCTGTCAACTGTAGCTCCTGTCCTGGGCCCCCGACAGCATCAC       CCTCGAGGCCGGTGCTTCATCTCCTCCAGCTCCTTTTAAGAACGAACTTGATGAAAACACAGACTTTA       CCTACAAGCCCGGCAGGAGCTCATGGTCCACACTCACTCGCTTTGGGGCTGACAGCCACTTTCCCAGG       GGAGCCTGGGGCCTCCCCTCGACTCTCACCAGGGCCTTCGACCCCTCCAGGAGCCCCCACTCTACCTC       TAGCTTCCCCAGGGGCTCCTCAGCCACCTCCTGTGACTCCAGAGCGCTCGTTCTCAGCCTCTGGGGCC       CAGATAGTGTCCAGGTGGCCTCCTCTGCCTGGCACCCTCCTGACGGAAGCTTCAGCACTTTCCATGAT       GGACCCCAGCCCCTCGAAGACCCCCATCACCCTCCTCGGGCCTCGCGTGCTTTCTCCCACCACCTCTA       GACTCTCCACAGCCCTTGCAGCCACCACCCACCCTGGCCCCCAGCAGCCCCCAGTGGGGGCTTCTCGG       GGGGAAGAGTCCACCATG TAA   GGAGGTCACT                                                   NOV59b, CG93871-05   SEQ ID NO: 1158   934 aa   MW at 97715.0kD               Protein Sequence                     MWAGLLLRAACVALLLPGAPARGYTGRKPPGHFAAERRRLGPRVCLSGFGSGCCPGWAPSMGGGHCTL           PLCSLGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAV       GIRCTDIDECVTSSCEGHCVNTEDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECR       RPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGR       PALSPGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLLQ       GEVMGTPSSPRGPESPRIAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSHPI       PSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCV       PVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPRBEWRLGPGQCCFTCQEPTPS       TGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTG       RIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFT       LDDEPCTRCTCQLGEVSCEKVPCQRACADPALLPGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRS       LHGDTEAPVNCSSCPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGE       PGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMD       PSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEESTM                                             NOV59c, 198488432   SEQ ID NO: 1159   1814 bp               DNA Sequence   ORF Start: at 1   ORF Stop: at 1813                     GGTACCCGAGGCTACACCGGGAGGAAGCCGCCCGGGCACTTCGCGGCCGAGAGACGCCGACTGGGCCC           CCACGTCTGCCTCTCTGGGTTTGGGAGTGGCTGCTGCCCTGGCTGGGCGCCCTCTATGGGTGGTGGGC       ACTGCACCCTGCCCCCCTGCTCCTTCGGCTGTGGGAGTGGCATCTGCATCGCTCCCAATGTCTGCTCC       TGCCAGGATGGAGAGCAAGGGGCCACCTGCCCAGAAACCCATGGACCATGTGGGGAGTACGGCTGTGA       CCTTACCTGCAACCATGGAGGCTGTCAGGAGGTGGCCCGAGTGTGCCCCGTGGGCTTCTCGATGACGG       AGACAGCTGTTGGCATCAGGTGTACAGACATTGACGAATGTGTAACCTCCTCCTGCGAGGGCCACTGT       GTGAACACAGAAAGTGGGTTTGTGTGCGAGTGTGGGCCGGGCATGCAGCTGTCTGCCGACCGCCACAG       CTGCCAAGACACTGACGAATGCCTAGGGACTCCCTGTCAGCAGAGATGTAAAAACAGCATTGGCAGCT       ACAAGTGTTCCTGTCGAACTGGCTTCCACCTTCATGGCAACCGGCACTCCTGTGTAGATGTAAACGAG       TGTCGGAGGCCATTGGAGAGGCGAGTCTGTCACCATTCCTGCCACAACACCGTGGGCAGCTTCCTATG       CACATGCCGACCTGGCTTCAGGCTCCGAGCTGACCGCGTGTCCTGTGAAGCTTTCCCGAAAGCCGTGC       TGGCCCCATCTGCCATCCTGCAACCCCGGCAACACCCGTCCAAGATGCTTCTGTTGCTTCCTGAGGCC       GGCCGGCCTGCCCTGTCCCCAGGACATAGCCCTCCTTCTGGGGCTCCAGGGCCCCCAGCCGGAGTCAG       GACCACCCGCCTGCCATCTCCCACCCCACGACTACCCACATCCTCCCCTTCTGCCCCTGTGTGGCTGC       TGTCCACCCTGCTGGCCACCCCAGTGCCTACTGCCTCCCTGCTGGGGAACCTCAGACCCCCCTCACTC       CTTCAGGGGGAGGTGATGGGGACCCCTTCCTCACCCAGGGGCCCTGAGTCCCCCCGACTGGCAGCAGG       GCCCTCTCCCTGCTGGCACCTGGGAGCCATGTATGAATCAAGGAGTCGCTGGACAGAGCCTGGGTGTT       CCCAGTGTTGGTGCGAGGACGGGAAGGTGACCTGTGAAAAGGTGAGGTGTGAAGCTGCTTGTTCCCAC       CCAATTCCCTCCAGAGATGGTGGGTGCTGCCCATCGTGCACAGGCTGTTTTCACAGTGGTGTCGTCCG       AGCTGAAGGGGATGTGTTTTCACCTCCCAATGAGAACTGCACCGTCTGTGTCTGTCTGGCTGGAAACG       TGTCCTGCATCTCTCCTGAGTGTCCTTCTGGCCCCTGTCAGACCCCCCCACAGACGGATTGCTGTACT       TGTGTTCCAGTGAGATGCTATTTCCACGGCCGGTGGTACGCAGACGGGGCTGTGTTCAGTGGGGGTGG       TGACGAGTGTACCACCTGTGTTTGCCAGAATGGGGAGGTGGAGTGCTCCTTCATGCCCTGCCCTGAGC       TGGCCTGCCCCCGAGAAGAGTGGCGGCTGGGCCCTGGGCAGTGTTGCTTCACCTGCCAGGAGCCCACA       CCCTCGACAGGCTGCTCTCTTGACGACAACGGGGTTGAGTTTCCGATTGGACAGATCTGGTCGCCTGG       TGACCCCTGTGAGTTATGCATCTGCCAGGCAGATGGCTCGGTGAGCTGCAAGAGGACAGACTGTGTGG       ACTCCTGCCCTCACCCGATCCGGATCCCTGGACAGTGCTGCTCGAG                                                 NOV59c, 198488432   SEQ ID NO: 1160   1604 aa   MW at 63737.5kD               Protein Sequence                     GTRGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHCTLPPCSFGCGSGICIAPNVCS           CQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHC       VNTESGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNE       CRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEA       GRPALSPGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSL       LQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMYESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSH       PIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCT       CVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPT       PSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCS                                             NOV59d, 198488424   SEQ ID NO: 1161   1790 bp               DNA Sequence   ORF Start: at 1   ORF Stop: at 1789                     GGTACCCGAGGCTACACCGGGAGGAAGCCGCCCGGGCACTTCGCGGCCGAGAGACGCCGACTGGGCCC           CCACGTCTGCCTCTCTGGGTTTGGGAGTGGCTGCTGCCCTGGCCGGGCGCCCTCTATGGGTGGTGGGC       ACTGCACCCTGCCCCTCTGCTCCTTCGGCTGTGGGAGTGGCATCTGCATCGCTCCCAATGTCTGCTCC       TGCCAGGATGGAGAGCAAGGGGCCACCTGCCCAGAAACCCATGGACCATGTGGGGAGTACGGCTGTGA       CCTTACCTGCAACCATGGAGGCTGTCAGGAGGTGGCCCGAGTGTGCCCCGTGGGCTTCTCGATGACGG       AGACAGCTGTTGGCATCAGGTGTACAGACATTGACGAATGTGTAACCTCCTCCTGCGAGGGCCACTGT       GTGAACACAGAAGGTGGGTTTGTGTGCGAGTGTGGGCCGGGCATGCAGCTGTCTGCCGACCGCCACAG       CTGCCAAGACACTGACGAATGCCTAGGGACTCCCTGTCAGCAGAGATGTAAAAACAGCATTGGCAGCT       ACAAGTGCTCCTGTCGAACTGGCTTCCACCTTCATGGCAACCGGCACTCCTGTGTAGATGTAAACGAG       TGTCGGAGGCCATTGGAGAGGCGAGTCTGTCACCATTCCTGCCACAACACCGTGGGCAGCTTCCTATG       CACATGCCGACCTGGCTTCAGGCTCCGAGCTGACCGCGTGTCCTGTGAAGCTTTCCCGAAAGCCGTGC       TGGCCCCATCTGCCATCCTGCAACCCCGGCAACACCCGTCCAAGATGCTTCTGTTGCTTCCTGAGGCC       GGCCGGCCTGCCCTGTCCCCAGGACATAGCCCTCCTTCTGGGGCTCCAGGGCCCCCAGCCGGAGTCAG       AACCACCCGCCTGCCATCTCCCACCCCACGACTACCCACATCCTCCCCTTCTGCCCCTGTGTGGCTGC       TGTCCACCCTGCTGGCCACCCCAGTGCCTACTGCCTCCCTGCTGGGGAACCTCAGACCCCCCTCACTC       CTTCAGGGGGAGGTGATGGGGACCCCTTCCTCACCCAGGGGCCCTGAGTCCCCCCGACTGGCAGCAGG       GCCCTCTCCCTGCTGGCACCTGGGAGCGATGCATGAATCAAGGAGTCGCTGGACAGAGCCTGGGTGTT       CCCAGTGCTGGTGCGAGGACGGGAAGGTGACCTGTGAAAAGGTGAGGTGTGAAGCTGCTTGTTCCCAC       CCAATTCCCTCCAGAGATGGTGGGTGCTGCCCATCGTGCACAGGCTGTTTTCACAGTGGTGTCGTCCG       AGCTGAAGGGGATGTGTTTTCACCTCCCAATGAGAACTGCACCGTCTGTGTCTGTCTGGCTGGAAACG       TGTCCTGCATCTCTCCTGAGGGTCCTTCTGGCCCCTGTCAGACCCCCCCACAGACGGATTGCTGTACT       TGTGTTCCAGTGAGATGCTATTTCCACGGCCGGTGGTACGCAGACGGGGCTGTGTTCAGTGGGGGTGG       TGACGAGTGTACCACCTGTGTTTGCCAGAATGGGGAGGTGGAGTGCTCCTTCATGCCCTGCCCTGAGC       TGGCCTGCCCCCGAGAAGAGTGGCGGCTGGGCCCTGGGCAGTGTTGCTTCACCTGCCAGGAGCCCACA       CCCTCGACAGGCTGCTCTCTTGACGACAACGGGGTTGAGTTTCCGATTGGACAGATCTGGTCGCCTGG       TGACCCCTATGGCTCGGTGAGCTGCAAGAGGACAGACTGTGTGGACTCCTGCCCTCACCCGATCCGGA       TCCCTGGACAGTGCTGCTCGAG                                                 NOV59d, 198488424   SEQ ID NO: 1162   596 aa   MW at 62805.5kD               Protein Sequence                     GTRGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGHAPSMGGGHCTLPLCSFGCGSGICIAPNVCS           CQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHC       VNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNE       CRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEA       GRPALSPGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSL       LQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSH       PIPSRDGGCCPSCTGCFHSGVVPAEGDVFSPPNENCTVCVCLAGNVSCISPEGPSGPCQTPPQTDCCT       CVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPT       PSTGCSLDDNGVEFPIGQIWSPGDPYGSVSCKRTDCVDSCPHPIRIPGQCCS                                             NOV59e, 198488428   SEQ ID NO: 1163   1661 bp               DNA Sequence   ORF Start: at 1   ORF Stop: at 1660                     GGTACCCGAGGCTACACCGGGAGGAAGCCGCCCGGGCACTTCGCGGCCGAGAGACGCCGACTGGGCCC           CCACGTCTGCCTCTCTGGGTTTGGGAGTGGCTGCTGCCCTGGCTGGGCGCCCTCTATGGGTGGTGGGC       ACTGCACCCTGCCCCTCTGCTCCTTCGGCTGTGGGAGTGGCATCTGCATCGCTCCCAATGTCTGCTCC       TGCCAGGATGGAGAGCAAGGGGCCACCTGCCCAGAAACCCATGGACCATGTGGGGAGTACGGCTGTGA       CCTTACCTGCAACCATGGGGGCTGTCAGGAGGTGGCCCGAGTGTGCCCCGTGGGCTTCTCGATGACGG       AGACAGCTGTTGGCATCAGGTGTACAGACATTGACGAATGTGTAACCTCCTCCTGCGAGGGCCACTGT       GTGAACACAGAAGGTGGGTTTGTGTGCGAGTGTGGGCCGGGCATGCAGCTGTCTGCCGACCGCCACAG       CTGCCAAGACACTGACGAATGCCTAGGGACTCCCTGTCAGCAGAGATGTAAAAACAGCATTGGCAGCT       ACAAGTGTTCCTGTCGAACTGGCTTCCACCTTCATGGCAACCGGCACTCCTGTGTAGCTTCCCCGAAA       GCCGTGCTGGCCCCATCTGCCATCCTGCAACCCCGGCAACACCCGTCCAAGATGCTTCTGTTGCTTCC       TGAGGCCGGCCGGCCTGCCCTGTCCCCAGGACATAGCCCTCCTTCTGGGGCTCCAGGGCCCCCAGCCG       GAGTCAGGACCACCCGCCTGCCATCTCCCACCCCACGACTACCCACATCCTCCCCTTCTGCCCCTGTG       TGGCTGCTGTCCACCCTGCTGGCCACCCCAGTGCCTACTGCCTCCCTGCTGGGGAACCTCAGACCCCC       CTCACTCCTTCAGGGGGAGGTGATGGGGACCCCTTCCTCACCCAGGGGCCCTGAGTCCCCCCGACTGG       CAGCAGGGCCCTCTCCCTGCTGGCACCTGGGAGCCATGCATGAATCAAGGAGTCGCTGGACAGAGCCT       GGGTGTTCCCAGTGCTGGTGCGAGGACGGGAAGGTGACCTGTGAAAAGGTGAGGTGTGAAGCTGCTTG       TTCCCACCCAATTCCCTCCAGAGATGGTGGGTGCTGCCCATCGTGCACAGGCTGTTTTCACAGTGGTG       TCGTCCGAGCTGAAGGGGATGTGTTTTCACCTCCCAATGAGAACTGCACCGTCTGTGTCTGTCTGGCT       GGAAACGTGTCCTGCATCTCTCCTGAGTGTCCTTCTGGCCCCTGTCAGACCCCCCCACAGACGGATTG       CTGTACTTGTGTTCCAGTGAGATGCTATTTCCACGGCCGGTGGTACGCAGACAGGGCTGTGTTCAGTG       GGGGTGGTGACGAGTGTACCACCTGTGTTTGCCAGAATGGGGAGGTGGAGTGCTCCTTCATGCCCTGC       CCTGAGCTGGCCTGCCCCCGAGAAGAGTGGCGGCTGGGCCCTGGGCAGTGTTGCTTCACCTGCCAGGA       GCCCACACCCTCGACAGGCTGCTCTCTTGACGACAACGGGGTTGAGTTTCCGATTGGACAGATCTGGT       CGCCTGGTGACCCCTATGGCTCGGTGAGCTGCAAGAGGACAGACTGTGTGGACTCCTGCCCTCACCCG       ATCCGGATCCCTGGACAGTGCTGCTCGAG                                                 NOV59e, 198488428   SEQ ID NO: 1164   553 aa   MW at 57922.0kD               Protein Sequence                     GTRGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCS           CQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHC       VNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVASPK       AVLAPSAILQPRQHPSKNLLLLPEAGRPALSPGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPV       WLLSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEP       GCSQCWCEDGKVTCEKVRCEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLA       GNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADRAVFSGGGDECTTCVCQNGEVECSFMPC       PELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPYGSVSCKRTDCVDSCPHP       IRIPGQCCS                                             NOV59f, 198488440   SEQ ID NO: 1165   1814 bp               DNA Sequence   ORF Start: at 1   ORF Stop: at 1813                     GGTACCCGAGGCTACACCGGGAAGAAGCCGCCCGGGCACTTCGCGGCCGAGAGACGCCGACTGGGCCC           CCACGTCTGCCTCTCTGGGTTTGGGAGTGGCTGCTGCCCTGGCTGGGCGCCCTCTATGGGTGGTGGGC       ACTGCACCCTGCCCCTCTGCTCCTTCGGCTGTGGGAGTGGCATCTGCATCGCTCCCAATGTCTGCTCC       TGCCAGGATGGAGAGCAAGGGGCCACCTGCCCAGAAACCCATGGACCATGTGGGGAGTACGGCTGTGA       CCTTACCTGCAACCATGGAGGCTGTCAGGAGGTGGCCCGAGTGTGCCCCGTGGGCTTCTCGATGACGG       AGACAGCTGTTGGCATCAGGTGTACAGACATTGACGAATGTGTAACCTCCTCCTGCGAGGGCCACTGT       GTGAACACAGAAGGTGGGTTTGTGTGCGAGTGTGGGCCGGGCATGCAGCTGTCTGCCGACCGCCACAG       CTGCCAAGACACTGACGAATGCCTAGGGACTCCCTGTCAGCAGAGATGTAAAAACAGCATTGGCAGCT       ACAAGTGCTCCTGTCGAACTGGCTTCCACCTTCATGGCAACCGGCACTCCTGTGTAGATGTAAACGAG       TGTCGGAGGCCATTGGAGAGGCGAGTCTGTCACCATTCCTGCCACAACACCGTGGGCAGCTTCCTATG       CACATGCCGACCTGGCTTCAGGCTCCGAGCTGACCGCGTGTCCTGTGAAGCTTTCCCGAAAGCCGTGC       TGGCCCCATCTGCCATCCTGCAACCCCGGCAACACCCGTCCAAGATGCTTCTGTTGCTTCCTGAGGCC       GGCCGGCCTGCCCTGTCCCCAGGACATAGCCCTCCTTCTGGGGCTCCAGGGCCCCCAGCCGGAGTCAG       GACCACCCGCCTGCCATCTCCCACCCCACGACTACCCACATCCTCCCCTTCTGCCCCTGTGTGGCTGC       TGTCCACCCTGCTGGCCACCCCAGTGCCTACTGCCTCCCTGCTGGGGAACCTCAGACCCCCCTCACTC       CTTCAGGGGGAGGTGATGGGGACCCCTTCCTCACCCAGGGGCCCTGAGTCCCCCCGACTGGCAGCAGG       GCCCTCTCCCTGCTGGCACCTGGGAGCGATGCATGAATCAAGGAGTCGCTGGACAGAGCCTGGGTGTT       CCCAGTGCTGGTGCGAGGACGGGAAGGTGACCTGTGAAAAGGTGCGGTGTGAAGCTGCTTGTTCCCAC       CCAATTCCCTCCAGAGATGGTGGGTGCTGCCCATCGTGCACAGGCTGTTTTCACAGTGGTGTCGTCCG       AGCTGAAGGGGATGTGTTTTCACCTCCCAATGAGAACTGCACCGTCTGTGTCTGTCTGGCTGGAAACG       TGTCCTGCATCTCTCCTGAGTGTCCTTCTGGCCCCTGTCAGACCCCCCCACAGACGGATTGCTGTACT       TGTGTTCCAGTGAGATGCTATTTCCACGGCCGGTGGTACGCAGACGGGGCTGTGTTCAGTGGGGGTGG       TGACGAGTGTACCACCTGTGTTTGCCAGAATGGGGAGGTGGAGTGCTCCTTCATGCCCTGCCCTGAGC       TGGCCTGCCCCCGAGAAGAGTGGCGGCCGGGCCCTGGGCAGTGTTGCTTCACCTGCCAGGAGCCCACA       CCCTCGACAGGCTGCTCTCTTGACGACAACGGGGTTGAGTTTCCGATTGGACAGATCTGGTCGCCTGG       TGACCCCTGTGAGTTATGCATCTGCCAGGCAGATGGCTCGGTGAGCTGCAAGAGGACAGACTGTGTGG       ACTCCTGCCCTCACCCGATCCGGATCCCTGGACAGTGCTGCTCGAG                                                 NOV59f, 198488440   SEQ ID NO: 1166   604 aa   MW at 63653.5kD               Proteing Sequence                     GTRGYTGKKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCS           CQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHC       VNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNE       CRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEA       GRPALSPGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSL       LQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSH       PIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCT       CVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRPGPGQCCFTCQEPT       PSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCS                                             NOV59g, CG93871-02   SEQ ID NO: 1167   585 bp               DNA Sequence   ORF Start: at 7   ORF Stop: at 580                     GGTACCTGCTCCTTCGGCTGTGGGAGTGGCATCTGCATCGCTCCTAATGTCTGCTCCTGCCAGGATGG           AGAGCAAGGGGCCACCTGCCCAGAAACCCATGGACCATGTGGGGAGTACGGCTGTGACCTTACCTGCA       ACCATGGAGGCTGTCAGGAGGTGGCCCGAGTGTGCCCCGTGGGCTTCTCGATGACGGAGACAGCTGTT       GGCATCAGGTGTACAGACATTGACGAATGTGTAACCTCCTCCTGCGAGGGCCACTGTGTGAACACAGA       AGGTGGGTTTGTGTGCGAGTGTGGGCCGGGCATGCAGCTGTCTGCCGACCGCCACAGCTGCCAAGACA       CTGACGAATGCCTAGGGACTCCCTGTCAGCAGGGATGTAAAAACAGCATTGGCAGCTACAAGTGTTCC       TGTCGAACTGGCTTCCACCTTCATGGCAACCGGCACTCCTGTGTAGATGTAAACGAGTGTCGGAGGCC       ATTGGAGAGGCGAGTCTGTCACCATTCCTGCCACAACACCGTGGGCAGCTTCCTATGCACATGCCGAC       CTCGAGACAGGCTCCGAGCTGACCGCGTGTCCTGTCTC GAG                                                   NOV59g, CG93871-02   SEQ ID NO: 1168   191 aa   MW at 20429.7kD               Protein Sequence                     CSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGI           RCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQGCKNSIGSYKCSCR       TGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPRDRLRADRVSC                                             NOV59h, CG93871-03   SEQ ID NO: 1169   2063 bp               DNA Sequence   ORF Start: ATG at 20   ORF Stop: TAG at 1229                       AGTGTTACAGTTCTTCAAG   ATG GTGTGTCCGGAGTTTGTTCCTTCAGATGTTCAGATGTGTCCAGAAT           TTCTTCCTTCTGGTGGGTTCGTGCTCTCACTGGCTTCAATGGGTGGTGGGCACTGCACCCTGCCCCTC       TGCTCCTTCGGCTGTGGGAGTGGCATCTGCATCGCTCCCAATGTCTGCTCCTGCCAGGATGGAGAGCA       AGGGGCCACCTGCCCAGAAACCCATGGACCATGTGGGGAGTACGGCTGTGACCTTACCTGCAACCATG       GAGGCTGTCAGGAGGTGGCCCGAGTGTGCCCCGTGGGCTTCTCGATGACGGAGACAGCTGTTGGCATC       AGGTGTACAGACATTGACGAATGTGTAACCTCCTCCTGCGAGGGCCACTGTGTGAACACAGAAGGTGG       GTTTGTGTGCGAGTGTGGGCCGGGCATGCAGCTGTCTGCCGACCGCCACAGCTGCCAAGACACTGACG       AATGCCTAGGGACTCCCTGTCAGCAGAGATGTAAAAACAGCATTGGCAGCTACAAGTGTTCCTGTCGA       ACTGGCTTCCACCTTCATGGCAACCGGCACTCCTGTGTAGATGTAAACGAGTGTCGGAGGCCATTGGA       GAGGCGAGTCTGTCACCATTCCTGCCACAACACCGTGGGCAGCTTCCTATGCACATGCCGACCTGGCT       TCAGGCTCCGAGCTGACCGCGTGTCCTGTGAAGCTTTCCCGAAAGCCGTGCTGGCCCCATCTGCCATC       CTGCAACCCCGGCAACACCCGTCCAAGATGCTTCTGTTGCTTCCTGAGGCCGGCCGGCCTGCCCTGTC       CCCAGGACATAGCCCTCCTTCTGGGGCTCCAGGGCCCCCAGCCGGAGTCAGGACCACCCGCCTGCCAT       CTCCCACCCCACGACTACCCACATCCTCCCCTTCTGCCCCTGTGTGGCTGCTGTCCACCCTGCTGGCC       ACCCCAGTGCCTACTGCCTCCCTGCTGGGGAACCTCAGACCCCCCTCACTCCTTCAGGGGGAGGTGAT       GAGGACCCCTTCCTCACCCAGGGGCCCTGAGTCCCCCCGACTGGCAGCAGGGCCCTCTCCCTGCTGGC       ACCTGGGAGCCATGCATGAATCAAGGAGTCGCTGGACAGAGCCTGGGTGTTCCCAGTGCTGGTGCGAG       GTGGGTACTAGGGGTCCCCGGAGCTTCCTTGGTCTGGGGCCTTGTGGTGGCTCTAACTCCTGCTTGTG       CTTC TAG   GACGGGAAGGTGACCTGTGAAAAGGTGAGGTGTGAAGCTGCTTGTTCCCACCCAATTCCCT           CCAGAGATGGTGGGTGCTGCCCATCGTGCACAGGTGAGAGCTGGTGCCAGGGAAGGACATAGTCCTGC           CTCTTCCTTTCTCTGCACCCTCCTGCAGCCAAAAGGCTGTTCTTTAACATTAGCATACATTAGAATCT           CCTGGAGGGTTTACTAAGCCACACTTCCCTTGGCGCTGCTCCCAGAGCTTCTGATGTAGTAGGTCTGG           GATAGGGCCAGAACATGTGCGTTTTGAACAGGTTCCCAGGTGATACTGACGTGGCTGGTCTAGGGACC           ATACTTTGAGAACCACTCATTTATGCTGTAATATGCCTCAAGGGGGACTTTTCATCTTCTGGGCATCT           GTTTTCAGCTTCATTCGCTCATTTTCATTTATTCAGTCATTCATTGAGCCTCTTTAAATCCACTGTGC           AGTCCCCTTCTCTTTCCGACTCACCTTCTCACATGGGGAGGAGTAGTTGCTTTACAATTCCCCCCCTT           TTTAATCTCCCCCCCCCCATATATCGATACTTCTTTATCTTCTTCCCATTCCTGGAAGAATAGGGACC           CATATTCTTCACCAAATCCTCAACTAGAGTTTCTTCTGAACTACCTCTCCAGCCCCTCAAGGGTATTC           TGATGACAAATACAAATTCTTCTCGTTGGCACGCTGTCTCTATCGCAGAACCCCACCACTTTGGGAGT           CCAATTTTGTCTTATCACTTGAGCGGACCATTCAGGGACTGTTTGGGATACTCGGTGATAAACGTCGP           GCATTCGTCTTTCTATCTCCTCA                                                   NOV59h, CG93871-03   SEQ ID NO: 1170   403 aa   MW at 42493.0kD               Protein Sequence                     MVCPEFVPSDVQMCPEFLPSGGFVLSLASMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPE           THGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECG       PGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHH       SCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPP       SGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLLQGEVMRTPSSP       RGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEVGTRGPRSFLGLGPCGGSNSCLCF                                             NOV59i, CG93871-04   SEQ ID NO: 1171   1790 bp               DNA Sequence   ORF Start: at 1   ORF Stop: at 1789                     GGTACCCGAGGCTACACCGGGAGGAAGCCGCCCGGGCACTTCGCGGCCGAGAGACGCCGACTGGGCCC           CCACGTCTGCCTCTCTGGGTTTGGGAGTGGCTGCTGCCCTGGCCGGGCGCCCTCTATGGGTGGTGGGC       ACTGCACCCTGCCCCTCTGCTCCTTCGGCTGTGGGAGTGGCATCTGCATCGCTCCCAATGTCTGCTCC       TGCCAGGATGGAGAGCAAGGGGCCACCTGCCCAGAAACCCATGGACCATGTGGGGAGTACGGCTGTGA       CCTTACCTGCAACCATGGAGGCTGTCAGGAGGTGGCCCGAGTGTGCCCCGTGGGCTTCTCGATGACGG       AGACAGCTGTTGGCATCAGGTGTACAGACATTGACGAATGTGTAACCTCCTCCTGCGAGGGCCACTGT       GTGAACACAGAAGGTGGGTTTGTGTGCGAGTGTGGGCCGGGCATGCAGCTGTCTGCCGACCGCCACAG       CTGCCAAGACACTGACGAATGCCTAGGGACTCCCTGTCAGCAGAGATGTAAAAACAGCATTGGCAGCT       ACAAGTGCTCCTGTCGAACTGGCTTCCACCTTCATGGCAACCGGCACTCCTGTGTAGATGTAAACGAG       TGTCGGAGGCCATTGGAGAGGCGAGTCTGTCACCATTCCTGCCACAACACCGTGGGCAGCTTCCTATG       CACATGCCGACCTGGCTTCAGGCTCCGAGCTGACCGCGTGTCCTGTGAAGCTTTCCCGAAAGCCGTGC       TGGCCCCATCTGCCATCCTGCAACCCCGGCAACACCCGTCCAAGATGCTTCTGTTGCTTCCTGAGGCC       GGCCGGCCTGCCCTGTCCCCAGGACATAGCCCTCCTTCTGGGGCTCCAGGGCCCCCAGCCGGAGTCAG       AACCACCCGCCTGCCATCTCCCACCCCACGACTACCCACATCCTCCCCTTCTGCCCCTGTGTGGCTGC       TGTCCACCCTGCTGGCCACCCCAGTGCCTACTGCCTCCCTGCTGGGGAACCTCAGACCCCCCTCACTC       CTTCAGGGGGAGGTGATGGGGACCCCTTCCTCACCCAGGGGCCCTGAGTCCCCCCGACTGGCAGCAGG       GCCCTCTCCCTGCTGGCACCTGGGAGCGATGCATGAATCAAGGAGTCGCTGGACAGAGCCTGGGTGTT       CCCAGTGCTGGTGCGAGGACGGGAAGGTGACCTGTGAAAAGGTGAGGTGTGAAGCTGCTTGTTCCCAC       CCAATTCCCTCCAGAGATGGTGGGTGCTGCCCATCGTGCACAGGCTGTTTTCACAGTGGTGTCGTCCG       AGCTGAAGGGGATGTGTTTTCACCTCCCAATGAGAACTGCACCGTCTGTGTCTGTCTGGCTGGAAACG       TGTCCTGCATCTCTCCTGAGGGTCCTTCTGGCCCCTGTCAGACCCCCCCACAGACGGATTGCTGTACT       TGTGTTCCAGTGAGATGCTATTTCCACGGCCGGTGGTACGCAGACGGGGCTGTGTTCAGTGGGGGTGG       TGACGAGTGTACCACCTGTGTTTGCCAGAATGGGGAGGTGGAGTGCTCCTTCATGCCCTGCCCTGAGC       TGGCCTGCCCCCGAGAAGAGTGGCGGCTGGGCCCTGGGCAGTGTTGCTTCACCTGCCAGGAGCCCACA       CCCTCGACAGGCTGCTCTCTTGACGACAACGGGGTTGAGTTTCCGATTGGACAGATCTGGTCGCCTGG       TGACCCCTATGGCTCGGTGAGCTGCAAGAGGACAGACTGTGTGGACTCCTGCCCTCACCCGATCCGGA       TCCCTGGACAGTGCTGCTCGAG                                                 NOV59i, CG93871-04   SEQ ID NO: 1172   596 aa   MW at 62805.5kD               Protein Sequence                     GTRGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGRAPSMGGGHCTLPLCSFGCGSGICIAPNVCS           CQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHC       VNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNE       CRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEA       GRPALSPGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSL       LQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSH       PIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPEGPSGPCQTPPQTDCCT       CVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPT       PSTGCSLDDNGVEFPIGQIWSPGDPYGSVSCKRTDCVDSCPHPIRIPGQCCS                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 59B.  
               TABLE 59B                       Comparison of the NOV59 protein sequences.                                        NOV59a MWAGLLLRAACVALLLPGAPARGYTGRKPPGHFAAERRRLGPNVCLSGFGSGCCPGWAPS           NOV59b MWAGLLLRAACVALLLPGAPARGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPS       NOV59c -------------------GTRGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPS       NOV59d -------------------GTRGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGRAPS       NOV59e -------------------GTRGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPS       NOV59f -------------------GTRGYTGKKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPS       NOV59g ------------------------------------------------------------       NOV59h -------------MVCP--------------EFVPS----DVQMCPEFLPSGGFVLSLAS       NOV59i -------------------GTRGYTGRKPPGHFAAERPRLGPHVCLSGFGSGCCPGRAPS               NOV59a MGGGHCTLRLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQE       NOV59b MGGGHCTLPLCSLGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQE       NOV59c MGGGHCTLPPCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQE       NOV59d MGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQE       NOV59e MGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQE       NOV59f MGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQE       NOV59g ----------CSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQE       NOV59h MGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQE       NOV59i MGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQE               NOV59a VARVCPVGFSMTETAVGIRC-DIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQ       NOV59b VARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTE---------------------       NOV59c VARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTESGFVCECGPGMQLSADRHSCQ       NOV59d VARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQ       NOV59e VARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQ       NOV59f VARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQ       NOV59g VARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQ       NOV59h VARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQ       NOV59i VARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQ               NOV59a DTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNT       NOV59b DTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNT       NOV59c DTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNT       NOV59d DTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNT       NOV59e DTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVAS-------------------       NOV59f DTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNT       NOV59g DTDECLGTPCQQGCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNT       NOV59h DTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNT       NOV59i DTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNT               NOV59a VGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGH       NOV59b VGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGH       NOV59c VGSFLCTCRPGFRLEADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGH       NOV59d VGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGH       NOV59e ------------------------PKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGH       NOV59f VGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGH       NOV59g VGSFLCTCRPRDRLRADRVSC---------------------------------------       NOV59h VGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGH       NOV59i VGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGH               NOV59a SPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLL       NOV59b SPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLL       NOV59c SPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLL       NOV59d SPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLL       NOV59e SPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLL       NOV59f SPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLL       NOV59g ------------------------------------------------------------       NOV59h SPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLL       NOV59i SPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLL               NOV59a QGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVR       NOV59b QGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVR       NOV59c QGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMYESRSRWTEPGCSQCWCEDGKVTCEKVR       NOV59d QGEVMGTPSSPRGPESPRIAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVR       NOV59e QGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVR       NOV59f QGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVR       NOV59g ------------------------------------------------------------       NOV59h QGEVMRTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEVG--------       NOV59i QGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVR               NOV59a CEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCMFREC       NOV59b CEAACSHPIPSRDGGCCPSCTGCFHSGVVPAEGDVFSPPNENCTVCVCLAGNVSCISPEC       NOV59c CEAACSHPIPSRDGGCCPSCTGCFHSGVVPAEGDVFSPPNENCTVCVCLAGNVSCISPEC       NOV59d CEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPEG       NOV59e CEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPEC       NOV59f CEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPEC       NOV59g ------------------------------------------------------------       NOV59h ----------------------------TRGPRSFLG-----------------------       NOV59i CEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPEG               NOV59a PFGPCETPHK--D------RCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPE       NOV59b PSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPE       NOV59c PSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPE       NOV59d PSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPE       NOV59e PSGPCQTPPQTDCCTCVPVRCYFHGRWYADRAVFSGGGDECTTCVCQNGEVECSFMPCPE       NOV59f PSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPE       NOV59g ------------------------------------------------------------       NOV59h -LGPCGGSNS--C------LCF--------------------------------------       NOV59i PSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPE               NOV59a LACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCR-------WLG       NOV59b LACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSV       NOV59c LACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQTWSPGDPCELCICQADGSV       NOV59d LACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQTWSPGDP--------YGSV       NOV59e LACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGD--------PYGSV       NOV59f LACPREEWRPGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSV       NOV59g ------------------------------------------------------------       NOV59h ------------------------------------------------------------       NOV59i LACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDP--------YGSV               NOV59a ELQEDRLCGLLPSPDPDPWTVLPRLFSR--------------------------------       NOV59b SCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVA       NOV59c SCKRTDCVDSCPHPIRIPGQCCS-------------------------------------       NOV59d SCKRTDCVDSCPHPIRIPGQCCS-------------------------------------       NOV59e SCKRTDCVDSCPHPIRIPGQCCS-------------------------------------       NOV59f SCKRTDCVDSCPHPIRIPGQCCS-------------------------------------       NOV59g ------------------------------------------------------------       NOV59h ------------------------------------------------------------       NOV59i SCKRTDCVDSCPHPIRIPGQCCS-------------------------------------               NOV59a ------------------------------------------------------------       NOV59b CSPVDCPITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCE       NOV59c ------------------------------------------------------------       NOV59d ------------------------------------------------------------       NOV59e ------------------------------------------------------------       NOV59f ------------------------------------------------------------       NOV59g ------------------------------------------------------------       NOV59h ------------------------------------------------------------       NOV59i ------------------------------------------------------------               NOV59a ------------------------------------------------------------       NOV59b KVPCQRACADPALLPGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNC       NOV59c ------------------------------------------------------------       NOV59d ------------------------------------------------------------       NOV59e ------------------------------------------------------------       NOV59f ------------------------------------------------------------       NOV59g ------------------------------------------------------------       NOV59h ------------------------------------------------------------       NOV59i ------------------------------------------------------------               NOV59a ------------------------------------------------------------       NOV59b SSCPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGA       NOV59c ------------------------------------------------------------       NOV59d ------------------------------------------------------------       NOV59e ------------------------------------------------------------       NOV59f ------------------------------------------------------------       NOV59g ------------------------------------------------------------       NOV59h ------------------------------------------------------------       NOV59i ------------------------------------------------------------               NOV59a ------------------------------------------------------------       N0V59b SPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASA       NOV59c ------------------------------------------------------------       NOV59d ------------------------------------------------------------       NOV59e ------------------------------------------------------------       NOV59f ------------------------------------------------------------       NOV59g ------------------------------------------------------------       NOV59h ------------------------------------------------------------       NOV59i ------------------------------------------------------------               NOV59a -------------------------------------------------------       NOV59b LSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEESTM       NOV59c -------------------------------------------------------       NOV59d -------------------------------------------------------       NOV59e -------------------------------------------------------       NOV59f -------------------------------------------------------       NOV59g -------------------------------------------------------       NOV59h -------------------------------------------------------       NOV59i -------------------------------------------------------               NOV59a (SEQ ID NO: 1156)       NOV59b (SEQ ID NO: 1158)       NOV59c (SEQ ID NO: 1160)       NOV59d (SEQ ID NO: 1162)       NOV59e (SEQ ID NO: 1164)       NOV59f (SEQ ID NO: 1166)       NOV59g (SEQ ID NO: 1168)       NOV59h (SEQ ID NO: 1170)       NOV59i (SEQ ID NO: 1172)                  
 
      Further analysis of the NOV59a protein yielded the following properties shown in Table 59C.  
               TABLE 59C                       Protein Sequence Properties NOV59a                                        SignalP analysis:   Cleavage site between residues 22 and 23       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 8; pos. chg 1; neg. chg 0           H-region:   length 13; peak value 9.31           PSG score:   4.91                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 1.18           possible cleavage site: between 21 and 22                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 21)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 22           Tentative number of TMS(s) for the threshold 0.5: 0           number of TMS(s) . . . fixed                             PERIPHERAL   Likelihood = 1.70 (at 70)                         ALOM score: 1.70 (number of TMSs: 0)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 10           Charge difference: 0.5 C(2.5)-N(2.0)           C &gt; N: C-terminal side will be inside                 &gt;&gt;&gt;Caution: Inconsistent mtop result with signal peptide                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   3   Hyd Moment(75):   9.30           Hyd Moment(95):   7.43   G content:   5           D/E content:   1   S/T content:   1                         Score: −3.74       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 79 LRL|CS                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 8.3%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear           discrimination           Prediction: nuclear           Reliability: 89       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         33.3%: extracellular, including cell wall           33.3%: mitochondrial           33.3%: nuclear                 &gt;&gt; prediction for CG93871-01 is exc (k = 9)                  
 
      A search of the NOV59a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 59D.  
               TABLE 59D                          Geneseq Results for NOV59a                                         NOV59a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #,Date]   Residues   Region   Value                                             ABU12085   Human NOV26a CG93871-01 protein   1 . . . 612   612/612   (100%)   0.0           SEQ ID 90 -  Homo sapiens , 612 aa.   1 . . . 612   612/612   (100%)           [WO200281625-A2, 17-OCT-2002]       ABU11798   Human MDDT polypeptide SEQ ID   381 . . . 580    192/208   (92%)   e−126           745 -  Homo sapiens , 514 aa.   1 . . . 208   195/208   (93%)           [WO200279449-A2, 10-OCT-2002]       AAB85364   Novel Von Willebrand/thrombosporin-   283 . . . 490    201/208   (96%)   e−124           like polypeptide -  Homo sapiens , 235   1 . . . 208   203/208   (96%)           aa. [WO200153485-A1, 26-JUL-2001]       AAM99920   Human polypeptide SEQ ID NO 36 -   388 . . . 580    185/201   (92%)   e−119             Homo sapiens , 272 aa.   5 . . . 205   188/201   (93%)           [WO200155173-A2, 02-AUG-2001]       AAM99933   Human polypeptide SEQ ID NO 49 -   388 . . . 580    181/201   (90%)   e−117             Homo sapiens , 212 aa.   5 . . . 205   185/201   (91%)           [WO200155173-A2, 02-AUG-2001]                  
 
      In a BLAST search of public sequence databases, the NOV59a protein was found to have homology to the proteins shown in the BLASTP data in Table 59E.  
               TABLE 59E                          Public BLASTP Results for NOV59a                                         NOV59a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               Q96DN2   Hypothetical protein FLJ32009 -   1 . . . 580   570/589 (96%)   0.0             Homo sapiens  (Human), 955 aa.   1 . . . 589   573/589 (96%)       AAH43473   1300015B04Rik protein -  Mus     1 . . . 606   507/615 (82%)   0.0             musculus  (Mouse), 608 aa.   1 . . . 607   538/615 (87%)       AAO47606   URG11 -  Homo sapiens  (Human),   283 . . . 580    290/306 (94%)   0.0           673 aa.   1 . . . 306   293/306 (94%)       Q8IVT0   Similar to hypothetical protein   1 . . . 218   216/219 (98%)         e−137           FLJ32009 -  Homo sapiens  (Human),   19 . . . 237    217/219 (98%)           237 aa (fragment).       Q8IXK1   C1q receptor protein precursor -   80 . . . 375    104/300 (34%)        6e−32             Homo sapiens  (Human), 652 aa.   300 . . . 566    134/300 (44%)                  
 
      PFam analysis predicts that the NOV59a protein contains the domains shown in the Table 59F.  
               TABLE 59F                          Domain Analysis of NOV59a                                             Identities/               Pfam   NOV59a   Similarities for   Expect           Domain   Match Region   the Matched Region   Value                                                 EGF   145 . . . 178   16/47 (34%)   0.0047                   23/47 (49%)           EGF   184 . . . 217   12/47 (26%)   0.012                   25/47 (53%)           TIL   165 . . . 223   13/70 (19%)   0.53                   40/70 (57%)           EGF   223 . . . 260   12/48 (25%)   0.045                   26/48 (54%)           vwc   385 . . . 439   21/84 (25%)   7.8e−08                   40/84 (48%)           vwc   442 . . . 492   18/84 (21%)   0.00017                   39/84 (46%)           vwc   493 . . . 550   21/84 (25%)   1.8e−07                   40/84 (48%)                      
 
     Example 60  
      The NOV60 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 60A.  
                                   TABLE 60A                                   NOV60 Sequence Analysis                          NOV60a, CG94946-01   SEQ ID NO: 1173   6224 bp               DNA Sequence   ORF Start: ATG at 37   ORF Stop: TGA at 6196                       CCGGCGCGGCCCGCGCGCTCTTCCGCCGCCTCTCGC   ATG CGCCATGGCCGGCCGGTCCCACCCGGGCC           CGCTGCGGGGCGGCCGCTGCTGCCTCTCCTTGTGGTGGCCGCGTGCGTCCTGCCCGGAGCCGGCGGGA       CATGCCCGGAGCGCGCGCTGGAGCGGCGCGAGGAGGAGGCGAACGTGGTGCTCACCGGGACGGTGGAG       GAGATCCTCAACGTGGACCCGGTGCAGCACACGTACTCCTGCAAGGTTCGGGTCTGGCGGTACTTGAA       GGGCAAAGACCTGGTGGCCCGGGAGAGCCTGCTGGACGGCGGCAACAAGGTGGTGATCAGCGGCTTTG       GAGACCCCCTCATCTGTGACAACCAGGTGTCCACTGGGGACACCAGGATCTTCTTTGTGAACCCTGCA       CCCCCATACCTGTGGCCAGCCCACAAGAACGAGCTGATGCTCAACTCCAGCCTCATGCGGATCACCCT       GCGGAACCTGGAGGAGGTGGAGTTCTGTGTGGAAGATAAACCCGGGACCCACTTCACTCCAGTGCCTC       CGACGCCTCCTGATGCGTGCCGGGGAATGCTGTGCGGCTTCGGCGCCGTGTGCGAGCCCAACGCGGAG       GGGCCGGGCCGGGCGTCCTGCGTCTGCAAGAAGAGCCCGTGCCCCAGCGTGGTGGCGCCTGTGTGTGG       GTCGGACGCCTCCACCTACAGCAACGAATGCGAGCTGCAGCGGGCGCAGTGCAGCCAGCAGCGCCGCA       TCCGCCTGCTCAGCCGCGGGCCGTGCGGCTCGCGGGACCCCTGCTCCAACGTGACCTGCAGCTTCGGC       AGCACCTGTGCGCGCTCGGCCGACGGGCTGACGGCCTCGTGCCTGTGCCCCGCGACCTGCCGTGGCGC       CCCCGAGGGGACCGTCTGCGGCAGCGACGGCGCCGACTACCCCGGCGAGTGCCAGCTCCTGCGCCGCG       CCTGCGCCCGCCAGGAGAATGTCTTCAAGAAGTTCGACGGCCCTTGTGACCCCTGTCAGGGCGCCCTC       CCTGACCCGAGCCGCAGCTGCCGTGTGAACCCGCGCACGCGGCGCCCTGAGATGCTCCTACGGCCCGA       GAGCTGCCCTGCCCGGCAGGCGCCAGTGTGTGGGGACGACGGAGTCACCTACGAAAACGACTGTGTCA       TGGGCCGATCGGGGGCCGCCCGGGGTCTCCTCCTGCAGAAAGTGCGCTCCGGCCAGTGCCAGGGTCGA       GACCAGTGCCCGGAGCCCTGCCGGTTCAATGCCGTGTGCCTGTCCCGCCGTGGCCGTCCCCGCTGCTC       CTGCGACCGCGTCACCTGTGACGGGGCCTACAGGCCCGTGTGTGCCCAGGACGGGCGCACGTATGACA       GTGATTGCTGGCGGCAGCAGGCTGAGTGCCGGCAGCAGCGTGCCATCCCCAGCAAGCACCAGGGCCCG       TGTGACCAGGCCCCGTCCCCATGCCTCGGGGTGCAGTGTGCATTTGGGGCGACGTGTGCTGTGAAGAA       CGGGCAGGCAGCGTGTGAATGCCTGCAGGCGTGCTCGAGCCTCTACGATCCTGTGTGCGGCAGCGACG       GCGTCACATACGGCAGCGCGTGCGAGCTGGAGGCCACGGCCTGTACCCTCGGGCGGGAGATCCAGGTG       GCGCGCAAAGGACCCTGTGACCGCTGCGGGCAGTGCCGCTTTGGAGCCCTGTGCGAGGCCGAGACCGG       GCGCTGCGTGTGCCCCTCTGAATGCGTGGCTTTGGCCCAGCCCGTGTGTGGCTCCGACGGGCACACGT       ACCCCAGCGAGTGCATGCTGCACGTGCACGCCTGCACACACCAGATCAGCCTGCACGTGGCCTCAGCT       GGACCCTGTGAGACCTGTGGAGATGCCGTGTGTGCTTTTGGGGCTGTGTGCTCCGCAGGGCAGTGTGT       GTGTCCCCGGTGTGAGCACCCCCCGCCCGGCCCCGTGTGTGGCAGCGACGGTGTCACCTACGGCAGTG       CCTGCGAGCTACGGGAAGCCGCCTGCCTCCAGCAGACACAGATCGAGGAGGCCCGGGCAGGGCCGTGC       GAGCAGGCCGAGTGCGGTTCCGGAGGCTCTGGCTCTGGGGAGGACGGTGACTGTGAGCAGGAGCTGTG       CCGGCAGCGCGGTGGCATCTGGGACGAGGACTCGGAGGACGGGCCGTGTGTCTGTGACTTCAGCTGCC       AGAGTGTCCCAGGCAGCCCGGTGTGCGGCTCAGATGGGGTCACCTACAGCACCGAGTGTGAGCTGAAG       AAGGCCAGGTGTGAGTCACAGCGAGGGCTCTACGTAGCGGCCCAGGGAGCCTGCCGAGGCCCCGCCTT       CGCCCCGCTGCCGCCTGTGGCCCCCTTACACTGTGCCCAGACGCCCTACGGCTGCTGCCAGGACAATA       TCACCGCAGCCCGGGGCGTGGGCCTGGCTGGCTGCCCCAGTGCCTGCCAGTGCAACCCCCATGGCTCT       TACGGCGGCACCTGTGACCCAGCCACAGGCCAGTGCTCCTGCCGCCCAGGTGTGGGGGGCCTCAGGTG       TGACCGCTGTGAGCCTGGCTTCTGGAACTTTCGAGGCATCGTCACCGATGGCCGGAGTGGCTGTACAC       CCTGCAGCTGTGATCCCCAAGGCGCCGTGCGGGATGACTGTGAGCAGATGACGGGGCTGTGCTCGTGT       AAGCCCGGGGTGGCTGGACCCAAGTGTGGGCAGTGTCCAGACGGCCGTGCCCTGGGCCCCGCGGGCTG       TGAAGCTGACGCTTCTGCGCCTGCGACCTGTGCGGAGATGCGCTGTGAGTTCGGTGCGCGGTGCGTGG       AGGAGTCTGGCTCAGCCCACTGTGTCTGCCCGATGCTCACCTGTCCAGAGGCCAACGCTACCAAGGTC       TGTGGGTCAGATGGAGTCACATACGGCAACGAGTGTCAGCTGAAGACCATCGCCTGCCGCCAGGGCCT       GCAAATCTCTATCCAGAGCCTGGGCCCGTGCCAGGAGGCTGTTGCTCCCAGCACTCACCCGACATCTG       CCTCCGTGACTGTGACCACCCCAGGGCTCCTCCTGAGCCAGGCACTGCCGGCCCCCCCCGGCGCCCTC       CCCCTGGCTCCCAGCAGTACCGCACACAGCCAGACCACCCCTCCGCCCTCATCGCGACCTCGGACCAC       TGCCAGCGTCCCCAGGACCACCGTGTGGCCCGTGCTGACGGTGCCCCCCACGGCACCCTCCCCTGCAC       CCAGCCTGGTGGCGTCCGCCTTTGGTGAATCTGGCAGCACTGATGGAAGCAGCGATGAGGAACTGAGC       GGGGACCAGGAGGCCAGTGGGGGTGGCTCTGGGGGGCTCGAGCCCTTGGAGGGCAGCAGCGTGGCCAC       CCCTGGGCCACCTGTCGAGAGGGCTTCCTGCTACAACTCCGCGTTGGGCTGCTGCTCTGATGGGAAGA       CGCCCTCGCTGGACGCAGAGGGCTCCAACTGCCCCGCCACCAAGGTGTTCCAGGGCGTCCTGGAGCTG       GAGGGCGTCGAGGGCCAGGAGCTGTTCTACACGCCCGAGATGGCTGACCCCAAGTCAGAACTGTTCGG       GGAGACAGCCAGGAGCATTGAGAGCACCCTGGACGACCTCTTCCGGAATTCAGACGTCAAGAAGGATT       TCCGGAGTGTCCGCTTGCGGGACCTGGGGCCCGGCAAATCCGTCCGCGCCATTGTGGATGTGCACTTT       GACCCCACCACAGCCTTCAGGGCACCCGACGTGGCCCGGGCCCTGCTCCGGCAGATCCAGGTGTCCAG       GCGCCGGTCCTTGGGGGTGAGGCGGCCGCTGCAGGAGCACGTGCGATTTATGGACTTTGACTGGTTTC       CTGCGTTTATCACGGGGGCCACGTCAGGAGCCATTGCTGCGGGAGCCACGGCCAGAGCCACCACTGCA       TCGCGCCTGCCGTCCTCTGCTGTGACCCCTCGGGCCCCGCACCCCAGTCACACAAGCCAGCCCGTTGC       CAAGACCACGGCAGCCCCCACCACACGTCGGCCCCCCACCACTGCCCCCAGCCGTGTGCCCGGACGTC       GGCCCCCGGCCCCCCAGCAGCCTCCAAAGCCCTGTGACTCACAGCCCTGCTTCCACGGGGGGACCTGC       CAGGACTGGGCATTGGGCGGGGGCTTCACCTGCAGCTGCCCGGCAGGCAGGGGAGGCGCCGTCTGTGA       GAAGGTGCTTGGCGCCCCTGTGCCGGCCTTCGAGGGCCGCTCCTTCCTGGCCTTCCCCACCCTCCGCG       CCTACCACACGCTGCGCCTGGCACTGGAATTCCGGGCGCTGGAGCCTCAGGGGCTGCTGCTGTACAAT       GGCAACGCCCGGGGCAAGGACTTCCTGGCATTGGCGCTGCTAGATGGCCGCGTGCAGCTCAGGTTTGA       CACAGGTTCGGGGCCGGCGGTGCTGACCAGTGCCGTGCCGGTAGAGCCGGGCCAGTGGCACCGCCTGG       AGCTGTCCCGGCACTGGCGCCGGGGCACCCTCTCGGTGGATGGTGAGACCCCTGTTCTGGGCGAGAGT       CCCAGTGGCACCGACGGCCTCAACCTGGACACAGACCTCTTTGTGGGCGGCGTACCCGAGGACCAGGC       TGCCGTGGCGCTGGAGCGGACCTTCGTGGGCGCCGGCCTGAGGGGGTGCATCCGTTTGCTGGACGTCA       ACAACCAGCGCCTGGAGCTTGGCATTGGGCCGGGGGCTGCCACCCGAGGCTCTGGCGTGGGCGAGTGC       GGGGACCACCCCTGCCTGCCCAACCCCTGCCATGGCGGGGCCCCATGCCAGAACCTGGAGGCTGGAAG       GTTCCATTGCCAGTGCCCGCCCGGCCGCGTCGGACCAACCTGTGCCGATGAGAAGAGCCCCTGCCAGC       CCAACCCCTGCCATGGGGCGGCGCCCTGCCGTGTGCTGCCCGAGGGTGGTGCTCAGTGCGAGTGCCCC       CTGGGGCGTGAGGGCACCTTCTGCCAGACAGCCTCGGGGCAGGACGGCTCTGGGCCCTTCCTGGCTGA       CTTCAACGGCTTCTCCCACCTGGAGCTGAGAGGCCTGCACACCATTGCACGGGACCTGGGGGAGAAGA       TGGCGCTGGAGGCCGTGTTCCTGGCACGAGGCCCCAGCGGCCTCCTGCTCTACAACGGGCAGAAGACG       GACGGCAAGGGGGACTTCGTGTCGCTGGCACTGCGGGACCGCCGCCTGGAGTTCCGCTACGACCTGGG       CAAGGGGGCAGCGGTCATCAGGAGCAGGGAGCCAGTCACCCTGGGAGCCTGGACCAGGGTCTCACTGG       AGCGAAACGGCCGCAAGGGTGCCCTGCGTGTGGGCGACGGCCCCCGTGTGTTGGGGGAGTCCCCGAAA       TCCCGCAAGGTTCCGCACACCGTCCTCAACCTGAAGGAGCCGCTCTACGTAGGGGGCGCTCCCGACTT       CAGCAAGCTGGCCCGTGCTGCTGCCGTGTCCTCTGGCTTCGACGGTGCCATCCAGCTGGTCTCCCTCG       GAGGCCGCCAGCTGCTGACCCCGGAGCACGTGCTGCGGCAGGTGGACGTCACGTCCTTTGCAGGTCAC       CCCTGCACCCGGGCCTCAGGCCACCCCTGCCTCAATGGGGCCTCCTGCGTCCCGAGGGAGGCTGCCTA       TGTGTGCCTGTGTCCCGGGGGATTCTCAGGACCGCACTGCGAGAAGGGGCTGGTGGAGAAGTCAGCGG       GGGACGTGGATACCTTGGCCTTTGACGGGCGGACCTTTGTCGAGTACCTCAACGCTGTGACCGAGAGC       GAGAAGGCACTGCAGAGCAACCACTTTGAACTGAGCCTGCGCACTGAGGCCACGCAGGGGCTGGTGCT       CTGGAGTGGCAAGGCCACGGAGCGGGCAGACTATGTGGCACTGGCCATTGTGGACGGGCACCTGCAAC       TGAGCTACAACCTGGGCTCCCAGCCCGTGGTGCTGCGTTCCACCGTGCCCGTCAACACCAACCGCTGG       TTGCGGGTCGTGGCACATAGGGAGCAGAGGGAAGGTTCCCTGCAGGTGGGCAATGAGGCCCCTGTGAC       CGGCTCCTCCCCGCTGGGCGCCACGCAGCTGGACACTGATGGAGCCCTGTGGCTTGGGGGCCTGCCGG       AGCTGCCCGTGGGCCCAGCACTGCCCAAGGCCTACGGCACAGGCTTTGTGGGCTGCTTGCGGGATGTG       GTGGTGGGCCGGCACCCGCTGCACCTGCTGGAGGACGCCGTCACCAAGCCAGAGCTGCGGCCCTGCCC       CACCCCA TGA   GCTGGCACCAGAGCCCCGCGCCCGCT                                                   NOV60a, CG94946-01   SEQ ID NO: 1174   2053 aa   MW at 215628.0kD               Protein Sequence                     MRHGRPVPPGPAAGRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTY           SCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRTFFVNPAPPYLWPAHKNEL       MLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKS       PCPSVVAPVCGSDASTYSNECELQPAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTA       SCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPR       TRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAV       CLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQ       CAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQC       RFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCA       FGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEAPAGPCEQAECGSGGSGS       GEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYV       AAQGACRGPAFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQC       SCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQC       PDGRALGPAGCEADASAPATCAEMRCEFGAPCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNEC       QLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQT       TPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGG       LEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTP       EMADPKSELFGETARSTESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVA       RALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRA       PHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCS       CPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALA       LLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTD       LFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHG       GAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTAS       GQDGSGPFLADFNGFSHLELRGLHTIARDLGEKMALEAVFLARGPSGLLLYNGQKTDGKGDFVSLALR       DRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLK       EPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLN       GASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESEKALQSNHFELS       LRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREG       SLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLED       AVTKPELRPCPTP                                             NOV60b, 275631590   SEQ ID NO: 1175   388 bp               DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                       C ACCGGATCCGCCACCAAGGTGTTCCAGGGCGTCCTGGAGCTGGAGGGCGTCGAGGGCCAGGAGCTGT           TCTACACGCCCGAGATGGCTGACCCCAAGTCAGAACTGTTCGGGGAGACAGCCAGGAGCATTGAGAGC       ACCCTGGACGACCTCTTCCGGAATTCAGACGTCAAGAAGGATTTCCGGAGTGTCCGCTTGCGGGACCT       GGGGCCCGGCAAATCCGTCCGCGCCATTGTGGATGTGCACTTTGACCCCACCACAGCCTTCAGGGCAC       CCGACGTGGCCCGGGCCCTGCTCCGGCAGATCCAGGTGTCCAGGCGCCGGTCCTTGGGGGTGAGGCGG       CCGCTGCAGGAGCACGTGCGATTTATGGACTTTGACTGGGTCGACGGC                                                 NOV60b, 275631590   SEQ ID NO: 1176   129 aa   MW at 14652.4kD               Protein Sequence                     TGSATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDL           GPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWVDG                                             NOV60c, 275631564   SEQ ID NO: 1177   316 bp               DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                   C ACCGGATCCTGCCAGTGCAACCCCCATGGCTCTTACGGCGGCACCTGTGACCCAGCCACAGGCCAGT       GCTCCTGCCGCCCAGGTGTGGGGGGCCTCAGGTGTGACCGCTGTGAGCCTGGCTTCTGGAACTTTCGA       GGCATCGTCACCGATGGCCGGAGTGGCTGTACACCCTGCAGCTGTGATCCCCAAGGCGCCGTGCGGGA       TGACTGTGAGCAGATGACGGGGCTGTGCTCGTGTAAGCCCGGGGTGGCTGGACCCAAGTGTGGGCAGT       GTCCAGACGGCCGTGCCCTGGGCCCCGCGGGCTGTGTCGACGGC                                                 NOV60c, 275631564   SEQ ID NO: 1178   105 aa   MW at 10579.7kD               Protein Sequence                     TGSCQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRD           DCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCVDG                                             NOV60d, CG94946-02   SEQ ID NO: 1179   4760 bp               DNA Sequence   ORF Start: ATG at 37   ORF Stop: TGA at 4732                     CCGGCGCGGCCCGCGCGCTCTTCCGCCGCCTCTCGCATGCGCCATGGCCGGCCGGTCCCACCCGGGCC           CGCTGCGGGGCGGCCGCTGCTGCCTCTCCTTGTGGTGGCCGCGTGCGTCCTGCCCGGAGCCGGCGGGA       CATGCCCGGAGCGCGCGCTGGAGCGGCGCGAGGAGGAGGCGAACGTGGTGCTCACCGGGACGGTGGAG       GAGATCCTCAACGTGGACCCGGTGCAGCACACGTACTCCTGCAAGGTTCGGGTCTGGCGGTACTTGAA       GGGCAAAGACCTGGTGGCCCGGGAGAGCCTGCTGGACGGCGGCAACAAGGTGGTGATCAGCGGCTTTG       GAGACCCCCTCATCTGTGACAACCAGGTGTCCACTGGGGACACCAGGATCTTCTTTGTGAACCCTGCA       CCCCCATACCTGTGGCCAGCCCACAAGAACGAGCTGATGCTCAACTCCAGCCTCATGCGGATCACCCT       GCGGAACCTGGAGGAGGTGGAGTTCTGTGTGGAAGATAAACCCGGGACCCACTTCACTCCAGTGCCTC       CGACGCCTCCTGATGCGTGCCGGGGAATGCTGTGCGGCTTCGGCGCCGTGTGCGAGCCCAACGCGGAG       GGGCCGGGCCGGGCGTCCTGCGTCTGCAAGAAGAGCCCGTGCCCCAGCGTGGTGGCGCCTGTGTGTGG       GTCGGACGCCTCCACCTACAGCAACGAATGCGAGCTGCAGCGGGCGCAGTGCAGCCAGCAGCGCCGCA       TCCGCCTGCTCAGCCGCGGGCCGTGCGGCTCGCGGGACCCCTGCTCCAACGTGACCTGCAGCTTCGGC       AGCACCTGTGCGCGCTCGGCCGACGGGCTGACGGCCTCGTGCCTGTGCCCCGCGACCTGCCGTGGCGC       CCCCGAGGGGACCGTCTGCGGCAGCGACGGCGCCGACTACCCCGGCGAGTGCCAGCTCCTGCGCCGCG       CCTGCGCCCGCCAGGAGAATGTCTTCAAGAAGTTCGACGGCCCTTGTGACCCCTGTCAGGGCGCCCTC       CCTGACCCGAGCCGCAGCTGCCGTGTGAACCCGCGCACGCGGCGCCCTGAGATGCTCCTACGGCCCGA       GAGCTGCCCTGCCCGGCAGGCGCCAGTGTGTGGGGACGACGGAGTCACCTACGAAAACGACTGTGTCA       TGGGCCGATCGGGGGCCGCCCGGGGTCTCCTCCTGCAGAAAGTGCGCTCCGGCCAGTGCCAGGGTCGA       GACCAGTGCCCGGAGCCCTGCCGGTTCAATGCCGTGTGCCTGTCCCGCCGTGGCCGTCCCCGCTGCTC       CTGCGACCGCGTCACCTGTGACGGGGCCTACAGGCCCGTGTGTGCCCAGGACGGGCGCACGTATGACA       GTGATTGCTGGCGGCAGCAGGCTGAGTGCCGGCAGCAGCGTGCCATCCCCAGCAAGCACCAGGGCCCG       TGTGACCAGGCCCCGTCCCCATGCCTCGGGGTGCAGTGTGCATTTGGGGCGACGTGTGCTGTGAAGAA       CGGGCAGGCAGCGTGTGAATGCCTGCAGGCGTGCTCGAGCCTCTACGATCCTGTGTGCGGCAGCGACG       GCGTCACATACGGCAGCGCGTGCGAGCTGGAGGCCACGGCCTGTACCCTCGGGCGGGAGATCCAGGTG       GCGCGCAAAGGACCCTGTGACCGCTGCGGGCAGTGCCGCTTTGGAGCCCTGTGCGAGGCCGAGACCGG       GCGCTGCGTGTGCCCCTCTGAATGCGTGGCTTTGGCCCAGCCCGTGTGTGGCTCCGACGGGCACACGT       ACCCCAGCGAGTGCATGCTGCACGTGCACGCCTGCACACACCAGATCAGCCTGCACGTGGCCTCAGCT       GGACCCTGTGAGACCTGTGGAGATGCCGTGTGTGCTTTTGGGGCTGTGTGCTCCGCAGGGCAGTGTGT       GTGTCCCCGGTGTGAGCACCCCCCGCCCGGCCCCGTGTGTGGCAGCGACGGTGTCACCTACGGCAGTG       CCTGCGAGCTACGGGAAGCCGCCTGCCTCCAGCAGACACAGATCGAGGAGGCCCGGGCAGGGCCGTGC       GAGCAGGCCGAGTGCGGTTCCGGAGGCTCTGGCTCTGGGGAGGACGGTGACTGTGAGCAGGAGCTGTG       CCGGCAGCGCGGTGGCATCTGGGACGAGGACTCGGAGGACGGGCCGTGTGTCTGTGACTTCAGCTGCC       AGAGTGTCCCAGGCAGCCCGGTGTGCGGCTCAGATGGGGTCACCTACAGCACCGAGTGTGAGCTGAAG       AAGGCCAGGTGTGAGTCACAGCGAGGGCTCTACGTAGCGGCCCAGGGAGCCTGCCGAGGCCCCGCCTT       CGCCCCGCTGCCGCCTGTGGCCCCCTTACACTGTGCCCAGACGCCCTACGGCTGCTGCCAGGACAATA       TCACCGCAGCCCGGGGCGTGGGCCTGGCTGGCTGCCCCAGTGCCTGCCAGTGCAACCCCCATGGCTCT       TACGGCGGCACCTGTGACCCAGCCACAGGCCAGTGCTCCTGCCGCCCAGGTGTGGGGGGCCTCAGGTG       TGACCGCTGTGAGCCTGGCTTCTGGAACTTTCGAGGCATCGTCACCGATGGCCGGAGTGGCTGTACAC       CCTGCAGCTGTGATCCCCAAGGCGCCGTGCGGGATGACTGTGAGCAGATGACGGGGCTGTGCTCGTGT       AAGCCCGGGGTGGCTGGACCCAAGTGTGGGCAGTGTCCAGACGGCCGTGCCCTGGGCCCCGCGGGCTG       TGAAGCTGACGCTTCTGCGCCTGCGACCTGTGCGGAGATGCGCTGTGAGTTCGGTGCGCGGTGCGTGG       AGGAGTCTGGCTCAGCCCACTGTGTCTGCCCGATGCTCACCTGTCCAGAGGCCAACGCTACCAAGGTC       TGTGGGTCAGATGGAGTCACATACGGCAACGAGTGTCAGCTGAAGACCATCGCCTGCCGCCAGGGCCT       GCAAATCTCTATCCAGAGCCTGGGCCCGTGCCAGGAGGCTGTTGCTCCCAGCACTCACCCGACATCTG       CCTCCGTGACTGTGACCACCCCAGGGCTCCTCCTGAGCCAGGCACTGCCGGCCCCCCCCGGCGCCCTC       CCCCTGGCTCCCAGCAGTACCGCACACAGCCAGACCACCCCTCCGCCCTCATCGCGACCTCGGACCAC       TGCCAGCGTCCCCAGGACCACCGTGTGGCCCGTGCTGACGGTGCCCCCCACGGCACCCTCCCCTGCAC       CCAGCCTGGTGGCGTCCGCCTTTGGTGAATCTGGCAGCACTGATGGAAGCAGCGATGAGGAACTGAGC       GGGGACCAGGAGGCCAGTGGGGGTGGCTCTGGGGGGCTCGAGCCCTTGGAGGGCAGCAGCGTGGCCAC       CCCTGGGCCACCTGTCGAGAGGGCTTCCTGCTACAACCCCTGCCATGGGGCGGCGCCCTGCCGTGTGC       TGCCCGAGGGTGGTGCTCAGTGCGAGTGCCCCCTGGGGCGTGAGGGCACCTTCTGCCAGACAGCCTCG       GGGCAGGACGGCTCTGGGCCCTTCCTGGCTGACTTCAACGGCTTCTCCCACCTGGAGCTGAGAGGCCT       GCACACCATTGCACGGGACCTGGGGGAGAAGATGGCGCTGGAGGCCGTGTTCCTGGCACGAGGCCCCA       GCGGCCTCCTGCTCTACAACGGGCAGAAGACGGACGGCAAGGGGGACTTCGTGTCGCTGGCACTGCGG       GACCGCCGCCTGGAGTTCCGCTACGACCTGGGCAAGGGGGCAGCGGTCATCAGGAGCAGGGAGCCAGT       CACCCTGGGAGCCTGGACCAGGGTCTCACTGGAGCGAAACGGCCGCAAGGGTGCCCTGCGTGTGGGCG       ACGGCCCCCGTGTGTTGGGGGAGTCCCCGAAATCCCGCAAGGTTCCGCACACCGTCCTCAACCTGAAG       GAGCCGCTCTACGTAGGGGGCGCTCCCGACTTCAGCAAGCTGGCCCGTGCTGCTGCCGTGTCCTCTGG       CTTCGACGGTGCCATCCAGCTGGTCTCCCTCGGAGGCCGCCAGCTGCTGACCCCGGAGCACGTGCTGC       GGCAGGTGGACGTCACGTCCTTTGCAGGTCACCCCTGCACCCGGGCCTCAGGCCACCCCTGCCTCAAT       GGGGCCTCCTGCGTCCCGAGGGAGGCTGCCTATGTGTGCCTGTGTCCCGGGGGATTCTCAGGACCGCA       CTGCGAGAAGGGGCTGGTGGAGAAGTCAGCGGGGGACGTGGATACCTTGGCCTTTGACGGGCGGACCT       TTGTCGAGTACCTCAACGCTGTGACCGAGAGCGAGAAGGCACTGCAGAGCAACCACTTTGAACTGAGC       CTGCGCACTGAGGCCACGCAGGGGCTGGTGCTCTGGAGTGGCAAGGCCACGGAGCGGGCAGACTATGT       GGCACTGGCCATTGTGGACGGGCACCTGCAACTGAGCTACAACCTGGGCTCCCAGCCCGTGGTGCTGC       GTTCCACCGTGCCCGTCAACACCAACCGCTGGTTGCGGGTCGTGGCACATAGGGAGCAGAGGGAAGGT       TCCCTGCAGGTGGGCAATGAGGCCCCTGTGACCGGCTCCTCCCCGCTGGGCGCCACGCAGCTGGACAC       TGATGGAGCCCTGTGGCTTGGGGGCCTGCCGGAGCTGCCCGTGGGCCCAGCACTGCCCAAGGCCTACG       GCACAGGCTTTGTGGGCTGCTTGCGGGATGTGGTGGTGGGCCGGCACCCGCTGCACCTGCTGGAGGAC       GCCGTCACCAAGCCAGAGCTGCGGCCCTGCCCCACCCCA TGA   GCTGGCACCAGAGCCCCGCGCCCGCT                                                   NOV60d, CG94946-02   SEQ ID NO: 1180   1565 aa   MW at 163817.1kD               Protein Sequence                     MRHGRPVPPGPAAGRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTY           SCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNEL       MLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKS       PCPSVVAPVCGSDASTYSNECELQRAQCSQQPRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTA       SCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPR       TRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAV       CLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQ       CAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQC       RFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCA       FGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGS       GEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYV       AAQGACRGPAFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQC       SCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQC       PDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNEC       QLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQT       TPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGG       LEPLEGSSVATPGPPVERASCYNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADF       NGFSHLELRGLHTIARDLGEKMALEAVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGK       GAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTTLNLKEPLYVGGAPDFS       KLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYV       CLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESEKALQSNHFELSLRTEATQGLVLW       SGKATERADYVALATVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTG       SSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPT       P                                             NOV60e, CG94946-03   SEQ ID NO: 1181   893 bp               DNA Sequence   ORF Start: ATG at 37   ORF Stop: TGA at 865                       CCGGCGCGGCCCGCGCGCTCTTCCGCCGCCTCTCGC   ATG CGCCATGGCCGGCCGGTCCCACCCGGGCC           CGCTGCGGGGCGGCCGCTGCTGCCTCTCCTTGTGGTGGCCGCGTGCGTCCTGCCCGGAGCCGGCGGGA       CATGCCCGGAGCGCGCGCTGGAGCGGCGCGAGGAGGAGGCGAACGTGGTGCTCACCGGGACGGTGGAG       GAGATCCTCAACGTGGACCCGGTGCAGCACACGTACTCCTGCAAGGTTCGGGTCTGGCGGTACTTGAA       GGGCAAAGACCTGGTGGCCCGGGAGAGCCTGCTGGACGGCGGCAACAAGGTGGTGATCAGCGGCTTTG       GAGACCCCCTCATCTGTGACAACCAGGTGTCCACTGGGGACACCAGGATCTTCTTTGTGAACCCTGCA       CCCCCATACCTGTGGCCAGCCCACAAGAACGAGCTGGTGCTCTGGAGTGGCAAGGCCACGGAGCGGGC       AGACTATGTGGCACTGGCCATTGTGGACGGGCACCTGCAACTGAGCTACAACCTGGGCTCCCAGCCCG       TGGTGCTGCGTTCCACCGTGCCCGTCAACACCAACCGCTGGTTGCGGGTCGTGGCACATAGGGAGCAG       AGGGAAGGTTCCCTGCAGGTGGGCAATGAGGCCCCTGTGACCGGCTCCTCCCCGCTGGGCGCCACGCA       GCTGGACACTGATGGAGCCCTGTGGCTTGGGGGCCTGCCGGAGCTGCCCGTGGGCCCAGCACTGCCCA       AGGCCTACGGCACAGGCTTTGTGGGCTGCTTGCGGGATGTGGTGGTGGGCCGGCACCCGCTGCACCTG       CTGGAGGACGCCGTCACCAAGCCAGAGCTGCGGCCCTGCCCCACCCCA TGA   GCTGGCACCAGAGCCCC           GCGCCCGCT                                                   NOV60e, CG94946-03   SEQ ID NO: 1182   276 aa   MW at 29688.8kD               Protein Sequence                     MRHGRPVPPGPAAGRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTY           SCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNEL       VLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAP       VTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRP       CPTP                                             NOV60f, CG94946-04   SEQ ID NO: 1183   1931 bp               DNA Sequence   ORF Start: ATG at 37   ORF Stop: TGA at 1903                       CCGGCGCGGCCCGCGCGCTCTTCCGCCGCCTCTCGC   ATG CGCCATGGCCGGCCGGTCCCACCCGGGCC           CGCTGCGGGGCGGCCGCTGCTGCCTCTCCTTGTGGTGGCCGCGTGCGTCCTGCCCGGAGCCGGCGGGA       CATGCCCGGAGCGCGCGCTGGAGCGGCGCGAGGAGGAGGCGAACGTGGTGCTCACCGGGACGGTGGAG       GAGATCCTCAACGTGGACCCGGTGCAGCACACGTACTCCTGCAAGGTTCGGGTCTGGCGGTACTTGAA       GGGCAAAGACCTGGTGGCCCGGGAGAGCCTGCTGGACGGCGGCAACAAGGTGGTGATCAGCGGCTTTG       GAGACCCCCTCATCTGTGACAACCAGGTGTCCACTGGGGACACCAGGATCTTCTTTGTGAACCCTGCA       CCCCCATACCTGTGGCCAGCCCACAAGAACGAGCTGATGCTCAACTCCAGCCTCATGCGGATCACCCT       GCGGAACCTGGAGGAGGTGGAGTTCTGTGTGGAAGATAAACCCGGGACCCACTTCACTCCAGTGCCTC       CGACGCCTCCTGATGCGTGCCGGGGAATGCTGTGCGGCTTCGGCGCCGTGTGCGAGCCCAACGCGGAG       GGGCCGGGCCGGGCGTCCTGCGTCTGCAAGAAGAGCCCGTGCCCCAGCGTGGTGGCGCCTGTGTGTGG       GTCGGACGCCTCCACCTACAGCAACGAATGCGAGCTGCAGCGGGCGCAGTGCAGCCAGCAGCGCCGCA       TCCGCCTGCTCAGCCGCGGGCCGTGCGGCTCGCGGGACCCCTGCTCCAACGTGACCTGCAGCTTCGGC       AGCACCTGTGCGCGCTCGGCCGACGGGCTGACGGCCTCGTGCCTGTGCCCCGCGACCTGCCGTGGCGC       CCCCGAGGGGACCGTCTGCGGCAGCGACGGCGCCGACTACCCCGGCGAGTGCCAGCTCCTGCGCCGCG       CCTGCGCCCGCCAGGAGAATGTCTTCAAGAAGTTCGACGGCCCTTGTGACCCCTGTCAGGGCGCCCTC       CCTGACCCGAGCCGCAGCTGCCGTGTGAACCCGCGCACGCGGCGCCCTGAGATGCTCCTACGGCCCGA       GAGCTGCCCTGCCCGGCAGGCGCCAGTGTGTGGGGACGACGGAGTCACCTACGAAAACGACTGTGTCA       TGGGCCGATCGGGGGCCGCCCGGGGTCTCCTCCTGCAGAAAGTGCGCTCCGGCCAGTGCCAGGGTCGA       GACCAGTGCCCGGAGCCCTGCCGGTTCAATGCCGTGTGCCTGTCCCGCCGTGGCCGTCCCCGCTGCTC       CTGCGACCGCGTCACCTGTGACGGGGCCTACAGGCCCGTGTGTGCCCAGGACGGGCGCACGTATGACA       GTGATTGCTGGCGGCAGCAGGCTGAGTGCCGGCAGCAGCGTGCCATCCCCAGCAAGCACCAGGGCCCG       TGTGACCAGGCCCCGTCCCCATGCCTCGGGGTGCAGTGTGCATTTGGGGCGACGTGTGCTGTGAAGAA       CGGGCAGGCAGCGTGTGAATGCCTGCAGGCGTGCTCGAGCCTCTACGATCCTGTGTGCGGCAGCGACG       GCGTCACATACGGCAGCGCGTGCGAGCTGGAGGCCACGGCCTGTACCCTCGGGCGGGAGATCCAGGTG       GCGCGCAAAGGACCCTGTGACCGCTGCGGGCAGTGCCGCTTTGGAGCCCTGCCTGTGACCGGCTCCTC       CCCGCTGGGCGCCACGCAGCTGGACACTGATGGAGCCCTGTGGCTTGGGGGCCTGCCGGAGCTGCCCG       TGGGCCCAGCACTGCCCAAGGCCTACGGCACAGGCTTTGTGGGCTGCTTGCGGGATGTGGTGGTGGGC       CGGCACCCGCTGCACCTGCTGGAGGACGCCGTCACCAAGCCAGAGCTGCGGCCCTGCCCCACCCC ATG           A   GCTGGCACCAGAGCCCCGCGCCCGCT                                                   NOV60f, CG94946-04   SEQ ID NO: 1184   622 aa   MW at 66353.9kD               Protein Sequence           MRHGRPVPPGPAAGRPLLPLLVVAACVLPGAGGTCPERALERREEEAIWVLTGTVEEILNVDPVQHTY           SCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNEL           MLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKS           PCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTA           SCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPR           TRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAV           CLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQ           CAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQC           RFGALPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVT           KPELRPCPTP                                                 NOV60g, CG94946-05   SEQ ID NO: 1185   4697 bp               DNA Sequence   ORF Start: ATG at 37   ORF Stop: TGA at 4669                       CCGGCGCGGCCCGCGCGCTCTTCCGCCGCCTCTCGC   ATG CGCCATGGCCGGCCGGTCCCACCCGGGCC           CGCTGCGGGGCGGCCGCTGCTGCCTCTCCTTGTGGTGGCCGCGTGCGTCCTGCCCGGAGCCGGCGGGA       CATGCCCGGAGCGCGCGCTGGAGCGGCGCGAGGAGGAGGCGAACGTGGTGCTCACCGGGACGGTGGAG       GAGATCCTCAACGTGGACCCGGTGCAGCACACGTACTCCTGCAAGGTTCGGGTCTGGCGGTACTTGAA       GGGCAAAGACCTGGTGGCCCGGGAGAGCCTGCTGGACGGCGGCAACAAGGTGGTGATCAGCGGCTTTG       GAGACCCCCTCATCTGTGACAACCAGGTGTCCACTGGGGACACCAGGATCTTCTTTGTGAACCCTGCA       CCCCCATACCTGTGGCCAGCCCACAAGAACGAGCTGATGCTCAACTCCAGCCTCATGCGGATCACCCT       GCGGAACCTGGAGGAGGTGGAGTTCTGTGTGGAAGATAAACCCGGGACCCACTTCACTCCAGTGCCTC       CGACGCCTCCTGATGCGTGCCGGGGAATGCTGTGCGGCTTCGGCGCCGTGTGCGAGCCCAACGCGGAG       GGGCCGGGCCGGGCGTCCTGCGTCTGCAAGAAGAGCCCGTGCCCCAGCGTGGTGGCGCCTGTGTGTGG       GTCGGACGCCTCCACCTACAGCAACGAATGCGAGCTGCAGCGGGCGCAGTGCAGCCAGCAGCGCCGCA       TCCGCCTGCTCAGCCGCGGGCCGTGCGGCTCGCGGGACCCCTGCTCCAACGTGACCTGCAGCTTCGGC       AGCACCTGTGCGCGCTCGGCCGACGGGCTGACGGCCTCGTGCCTGTGCCCCGCGACCTGCCGTGGCGC       CCCCGAGGGGACCGTCTGCGGCAGCGACGGCGCCGACTACCCCGGCGAGTGCCAGCTCCTGCGCCGCG       CCTGCGCCCGCCAGGAGAATGTCTTCAAGAAGTTCGACGGCCCTTGTGACCCCTGTCAGGGCGCCCTC       CCTGACCCGAGCCGCAGCTGCCGTGTGAACCCGCGCACGCGGCGCCCTGAGATGCTCCTACGCCCCGA       GAGCTGCCCTGCCCGGCAGGCGCCAGTGTGTGGGGACGACGGAGTCACCTACGAAAACGACTGTGTCA       TGGGCCGATCGGGGGCCGCCCGGGGTCTCCTCCTGCAGAAAGTGCGCTCCGGCCAGTGCCAGGGTCGA       GACCAGTGCCCGGAGCCCTGCCGGTTCAATGCCGTGTGCCTGTCCCGCCGTGGCCGTCCCCGCTGCTC       CTGCGACCGCGTCACCTGTGACGGGGCCTACAGGCCCGTGTGTGCCCAGGACGGGCGCACGTATGACA       GTGATTGCTGGCGGCAGCAGGCTGAGTGCCGGCAGCAGCGTGCCATCCCCAGCAAGCACCAGGGCCCG       TGTGACCAGGCCCCGTCCCCATGCCTCGGGGTGCAGTGTGCATTTGGGGCGACGTGTGCTGTGAAGAA       CGGGCAGGCAGCGTGTGAATGCCTGCAGGCGTGCTCGAGCCTCTACGATCCTGTGTGCGGCAGCGACG       GCGTCACATACGGCAGCGCGTGCGAGCTGGAGGCCACGGCCTGTACCCTCGGGCGGGAGATCCAGGTG       GCGCGCAAAGGACCCTGTGACCGCTGCGGGCAGTGCCGCTTTGGAGCCCTGTGCGAGGCCGAGACCGG       GCGCTGCGTGTGCCCCTCTGAATGCGTGGCTTTGGCCCAGCCCGTGTGTGGCTCCGACGGGCACACGT       ACCCCAGCGAGTGCATGCTGCACGTGCACGCCTGCACACACCAGATCAGCCTGCACGTGGCCTCAGCT       GGACCCTGTGAGACCTGTGGAGATGCCGTGTGTGCTTTTGGGGCTGTGTGCTCCGCAGGGCAGTGTGT       GTGTCCCCGGTGTGAGCACCCCCCGCCCGGCCCCGTGTGTGGCAGCGACGGTGTCACCTACGGCAGTG       CCTGCGAGCTACGGGAAGCCGCCTGCCTCCAGCAGACACAGATCGAGGAGGCCCGGGCAGGGCCGTGC       GAGCAGGCCGAGTGCGGTTCCGGAGGCTCTGGCTCTGGGGAGGACGGTGACTGTGAGCAGGAGCTGTG       CCGGCAGCGCGGTGGCATCTGGGACGAGGACTCGGAGGACGGGCCGTGTGTCTGTGACTTCAGCTGCC       AGAGTGTCCCAGGCAGCCCGGTGTGCGGCTCAGATGGGGTCACCTACAGCACCGAGTGTGAGCTGAAG       AAGGCCAGGTGTGAGTCACAGCGAGGGCTCTACGTAGCGGCCCAGGGAGCCTGCCGAGGCCCCGCCTT       CGCCCCGCTGCCGCCTGTGGCCCCCTTACACTGTGCCCAGACGCCCTACGGCTGCTGCCAGGACAATA       TCACCGCAGCCCGGGGCGTGGGCCTGGCTGGCTGCCCCAGTGCCTGCCAGTGCAACCCCCATGGCTCT       TACGGCGGCACCTGTGACCCAGCCACAGGCCAGTGCTCCTGCCGCCCAGGTGTGGGGGGCCTCAGGTG       TGACCGCTGTGAGCCTGGCTTCTGGAACTTTCGAGGCATCGTCACCGATGGCCGGAGTGGCTGTACAC       CCTGCAGCTGTGATCCCCAAGGCGCCGTGCGGGATGACTGTGAGCAGATGACGGGGCTGTGCTCGTGT       AAGCCCGGGGTGGCTGGACCCAAGTGTGGGCAGTGTCCAGACGGCCGTGCCCTGGGCCCCGCGGGCTG       TGAAGCTGACGCTTCTGCGCCTGCGACCTGTGCGGAGATGCGCTGTGAGTTCGGTGCGCGGTGCGTGG       AGGAGTCTGGCTCAGCCCACTGTGTCTGCCCGATGCTCACCTGTCCAGAGGCCAACGCTACCAAGGTC       TGTGGGTCAGATGGAGTCACATACGGCAACGAGTGTCAGCTGAAGACCATCGCCTGCCGCCAGGGCCT       GCAAATCTCTATCCAGAGCCTGGGCCCGTGCCAGGAGGCTGTTGCTCCCAGCACTCACCCGACATCTG       CCTCCGTGACTGTGACCACCCCAGGGCTCCTCCTGAGCCAGGCACTGCCGGCCCCCCCCGGCGCCCTC       CCCCTGGCTCCCAGCAGTACCGCACACAGCCAGACCACCCCTCCGCCCTCATCGCGACCTCGGACCAC       TGCCAGCGTCCCCAGGACCACCGTGTGGCCCGTGCTGACGGTGCCCCCCACGGCACCCTCCCCTGCAC       CCAGCCTGGTGGCGTCCGCCTTTGGTGAATCTGGCAGCACTGATGGAAGCAGCGATGAGGAACTGAGC       GGGGACCAGGAGGCCAGTGGGGGTGGCTCTGGGGGGCTCGAGCCCTTGGAGGGCAGCAGCGTGGCCAC       CCCTGGGCCACCTGTCGAGAGGGCTTCCTGCTACAACTCCGCGTTGGGCTGCTGCTCTGATGGGAAGA       CGCCCTCGCTGGACGCAGAGGGCTCCAACTGCCCCGCCACCAAGGTGTTCCAGGGCGTCCTGGAGCTG       GAGGGCGTCGAGGGCCAGGAGCTGTTCTACACGCCCGAGATGGCTGACCCCAAGTCAGAACTGTTCGG       GGAGACAGCCAGGAGCATTGAGAGCACCCTGGACGACCTCTTCCGGAATTCAGACGTCAAGAAGGATT       TCCGGAGTGTCCGCTTGCGGGACCTGGGGCCCGGCAAATCCGTCCGCGCCATTGTGGATGTGCACTTT       GACCCCACCACAGCCTTCAGGGCACCCGACGTGGCCCGGGCCCTGCTCCGGCAGATCCAGGTGTCCAG       GCGCCGGTCCTTGGGGGTGAGGCGGCCGCTGCAGGAGCACGTGCGATTTATGGACTTTGACTGGTTTC       CTGCGTTTATCACGGGGGCCACGTCAGGAGCCATTGCTGCGGGAGCCACGGCCAGAGCCACCACTGCA       TCGCGCCTGCCGTCCTCTGCTGTGACCCCTCGGGCCCCGCACCCCAGTCACACAAGCCAGCCCGTTGC       CAAGACCACGGCAGCCCCCACCACACGTCGGCCCCCCACCACTGCCCCCAGCCGTGTGCCCGGACGTC       GGCCCCCGGCCTCCTGCGTCCCGAGGGAGGCTGCCTATGTGTGCCTGTGTCCCGGGGGATTCTCAGGA       CCGCACTGCGAGAAGGGGCTGGTGGAGAAGTCAGCGGGGGACGTGGATACCTTGGCCTTTGACGGGCG       GACCTTTGTCGAGTACCTCAACGCTGTGACCGAGAGCGAGAAGGCACTGCAGAGCAACCACTTTGAAC       TGAGCCTGCGCACTGAGGCCACGCAGGGGCTGGTGCTCTGGAGTGGCAAGGCCACGGAGCGGGCAGAC       TATGTGGCACTGGCCATTGTGGACGGGCACCTGCAACTGAGCTACAACCTGGGCTCCCAGCCCGTGGT       GCTGCGTTCCACCGTGCCCGTCAACACCAACCGCTGGTTGCGGGTCGTGGCACATAGGGAGCAGAGGG       AAGGTTCCCTGCAGGTGGGCAATGAGGCCCCTGTGACCGGCTCCTCCCCGCTGGGCGCCACGCAGCTG       GACACTGATGGAGCCCTGTGGCTTGGGGGCCTGCCGGAGCTGCCCGTGGGCCCAGCACTGCCCAAGGC       CTACGGCACAGGCTTTGTGGGCTGCTTGCGGGATGTGGTGGTGGGCCGGCACCCGCTGCACCTGCTGG       AGGACGCCGTCACCAAGCCAGAGCTGCGGCCCTGCCCCACCCCA TGA           CCGCT                                                   NOV60g, CG94946-05   SEQ ID NO: 1186   1544 aa   MW at 162003.7kD               Protein Sequence                     MRHGRPVPPGPAAGRPLLPLLVVAACVLPGAGGTCPERAIERREEEAINVLTGTVEEILNVDPVQHTY           SCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNEL       MLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGPASCVCKKS       PCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTA       SCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPR       TRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAV       CLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQ       CAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCCRCGQC       RFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCA       FGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGS       GEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYV       AAQGACRGPAFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQC       SCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQC       PDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNEC       QLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQT       TPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGG       LEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTP       EMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVA       RALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRA       PHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGPRPPASCVPREAAYVCLCPGGFSGPHCEKGLVEKSA       GDVDTLAFDGRTFVEYLNAVTESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQ       LSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLP       ELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP                                             NOV60h, CG94946-06   SEQ ID NO: 1187   6494 bp               DNA Sequence   ORF Start: ATG at 37   ORF Stop: TGA at 6466                       CCGGCGCGGCCCGCGCGCTCTTCCGCCGCCTCTCGC   ATG CGCCATGGCCGGCCGGTCCCACCCGGGCC           CGCTGCGGGGCGGCCGCTGCTGCCTCTCCTTGTGGTGGCCGCGTGCGTCCTGCCCGGAGCCGGCGGGA       CATGCCCGGAGCGCGCGCTGGAGCGGCGCGAGGAGGAGGCGAACGTGGTGCTCACCGGGACGGTGGAG       GAGATCCTCAACGTGGACCCGGTGCAGCACACGTACTCCTGCAAGGTTCGGGTCTGGCGGTACTTGAA       GGGCAAAGACCTGGTGGCCCGGGAGAGCCTGCTGGACGGCGGCAACAAGGTGGTGATCAGCGGCTTTG       GAGACCCCCTCATCTGTGACAACCAGGTGTCCACTGGGGACACCAGGATCTTCTTTGTGAACCCTGCA       CCCCCATACCTGTGGCCAGCCCACAAGAACGAGCTGATGCTCAACTCCAGCCTCATGCGGATCACCCT       GCGGAACCTGGAGGAGGTGGAGTTCTGTGTGGAAGATAAACCCGGGACCCACTTCACTCCAGTGCCTC       CGACGCCTCCTGATGCGTGCCGGGGAATGCTGTGCGGCTTCGGCGCCGTGTGCGAGCCCAACGCGGAG       GGGCCGGGCCGGGCGTCCTGCGTCTGCAAGAAGAGCCCGTGCCCCAGCGTGGTGGCGCCTGTGTGTGG       GTCGGACGCCTCCACCTACAGCAACGAATGCGAGCTGCAGCGGGCGCAGTGCAGCCAGCAGCGCCGCA       TCCGCCTGCTCAGCCGCGGGCCGTGCGGCTCGCGGGACCCCTGCTCCAACGTGACCTGCAGCTTCGGC       AGCACCTGTGCGCGCTCGGCCGACGGGCTGACGGCCTCGTGCCTGTGCCCCGCGACCTGCCGTGGCGC       CCCCGAGGGGACCGTCTGCGGCAGCGACGGCGCCGACTACCCCGGCGAGTGCCAGCTCCTGCGCCGCG       CCTGCGCCCGCCAGGAGAATGTCTTCAAGAAGTTCGACGGCCCTTGTGACCCCTGTCAGGGCGCCCTC       CCTGACCCGAGCCGCAGCTGCCGTGTGAACCCGCGCACGCGGCGCCCTGAGATGCTCCTACGGCCCGA       GAGCTGCCCTGCCCGGCAGGCGCCAGTGTGTGGGGACGACGGAGTCACCTACGAAAACGACTGTGTCA       TGGGCCGATCGGGGGCCGCCCGGGGTCTCCTCCTGCAGAAAGTGCGCTCCGGCCAGTGCCAGGGTCGA       GACCAGTGCCCGGAGCCCTGCCGGTTCAATGCCGTGTGCCTGTCCCGCCGTGGCCGTCCCCGCTGCTC       CTGCGACCGCGTCACCTGTGACGGGGCCTACAGGCCCGTGTGTGCCCAGGACGGGCGCACGTATGACA       GTGATTGCTGGCGGCAGCAGGCTGAGTGCCGGCAGCAGCGTGCCATCCCCAGCAAGCACCAGGGCCCG       TGTGACCAGGCCCCGTCCCCATGCCTCGGGGTGCAGTGTGCATTTGGGGCGACGTGTGCTGTGAAGAA       CGGGCAGGCAGCGTGTGAATGCCTGCAGGCGTGCTCGAGCCTCTACGATCCTGTGTGCGGCAGCGACG       GCGTCACATACGGCAGCGCGTGCGAGCTGGAGGCCACGGCCTGTACCCTCGGGCGGGAGATCCAGGTG       GCGCGCAAAGGACCCTGTGACCGCTGCGGGCAGTGCCGCTTTGGAGCCCTGTGCGAGGCCGAGACCGG       GCGCTGCGTGTGCCCCTCTGAATGCGTGGCTTTGGCCCAGCCCGTGTGTGGCTCCGACGGGCACACGT       ACCCCAGCGAGTGCATGCTGCACGTGCACGCCTGCACACACCAGATCAGCCTGCACGTGGCCTCAGCT       GGACCCTGTGAGACCTGTGGAGATGCCGTGTGTGCTTTTGGGGCTGTGTGCTCCGCAGGGCAGTGTGT       GTGTCCCCGGTGTGAGCACCCCCCGCCCGGCCCCGTGTGTGGCAGCGACGGTGTCACCTACGGCAGTG       CCTGCGAGCTACGGGAAGCCGCCTGCCTCCAGCAGACACAGATCGAGGAGGCCCGGGCAGGGCCGTGC       GAGCAGGCCGAGTGCGGTTCCGGAGGCTCTGGCTCTGGGGAGGACGGTGACTGTGAGCAGGAGCTGTG       CCGGCAGCGCGGTGGCATCTGGGACGAGGACTCGGAGGACGGGCCGTGTGTCTGTGACTTCAGCTGCC       AGAGTGTCCCAGGCAGCCCGGTGTGCGGCTCAGATGGGGTCACCTACAGCACCGAGTGTGAGCTGAAG       AAGGCCAGGTGTGAGTCACAGCGAGGGCTCTACGTAGCGGCCCAGGGAGCCTGCCGAGGCCCCGCCTT       CGCCCCGCTGCCGCCTGTGGCCCCCTTACACTGTGCCCAGACGCCCTACGGCTGCTGCCAGGACAATA       TCACCGCAGCCCGGGGCGTGGGCCTGGCTGGCTGCCCCAGTGCCTGCCAGTGCAACCCCCATGGCTCT       TACGGCGGCACCTGTGACCCAGCCACAGGCCAGTGCTCCTGCCGCCCAGGTGTGGGGGGCCTCAGGTG       TGACCGCTGTGAGCCTGGCTTCTGGAACTTTCGAGGCATCGTCACCGATGGCCGGAGTGGCTGTACAC       CCTGCAGCTGTGATCCCCAAGGCGCCGTGCGGGATGACTGTGAGCAGATGACGGGGCTGTGCTCGTGT       AAGCCCGGGGTGGCTGGACCCAAGTGTGGGCAGTGTCCAGACGGCCGTGCCCTGGGCCCCGCGGGCTG       TGAAGCTGACGCTTCTGCGCCTGCGACCTGTGCGGAGATGCGCTGTGAGTTCGGTGCGCGGTGCGTGG       AGGAGTCTGGCTCAGCCCACTGTGTCTGCCCGATGCTCACCTGTCCAGAGGCCAACGCTACCAAGGTC       TGTGGGTCAGATGGAGTCACATACGGCAACGAGTGTCAGCTGAAGACCATCGCCTGCCGCCAGGGCCT       GCAAATCTCTATCCAGAGCCTGGGCCCGTGCCAGGAGGCTGTTGCTCCCAGCACTCACCCGACATCTG       CCTCCGTGACTGTGACCACCCCAGGGCTCCTCCTGAGCCAGGCACTGCCGGCCCCCCCCGGCGCCCTC       CCCCTGGCTCCCAGCAGTACCGCACACAGCCAGACCACCCCTCCGCCCTCATCGCGACCTCGGACCAC       TGCCAGCGTCCCCAGGACCACCGTGTGGCCCGTGCTGACGGTGCCCCCCACGGCACCCTCCCCTGCAC       CCAGCCTGGTGGCGTCCGCCTTTGGTGAATCTGGCAGCACTGATGGAAGCAGCGATGAGGAACTGAGC       GGGGACCAGGAGGCCAGTGGGGGTGGCTCTGGGGGGCTCGAGCCCTTGGAGGGCAGCAGCGTGGCCAC       CCCTGGGCCACCTGTCGAGAGGGCTTCCTGCTACAACTCCGCGTTGGGCTGCTGCTCTGATGGGAAGA       CGCCCTCGCTGGACGCAGAGGGCTCCAACTGCCCCGCCACCAAGGTGTTCCAGGGCGTCCTGGAGCTG       GAGGGCGTCGAGGGCCAGGAGCTGTTCTACACGCCCGAGATGGCTGACCCCAAGTCAGAACTGTTCGG       GGAGACAGCCAGGAGCATTGAGAGCACCCTGGACGACCTCTTCCGGAATTCAGACGTCAAGAAGGATT       TCCGGAGTGTCCGCTTGCGGGACCTGGGGCCCGGCAAATCCGTCCGCGCCATTGTGGATGTGCACTTT       GACCCCACCACAGCCTTCAGGGCACCCGACGTGGCCCGGGCCCTGCTCCGGCAGATCCAGGTGTCCAG       GCGCCGGTCCTTGGGGGTGAGGCGGCCGCTGCAGGAGCACGTGCGATTTATGGACTTTGACTGGTTTC       CTGCGTTTATCACGGGGGCCACGTCAGGAGCCATTGCTGCGGGAGCCACGGCCAGAGCCACCACTGCA       TCGCGCCTGCCGTCCTCTGCTGTGACCCCTCGGGCCCCGCACCCCAGTCACACAAGCCAGCCCGTTGC       CAAGACCACGGCAGCCCCCACCACACGTCGGCCCCCCACCACTGCCCCCAGCCGTGTGCCCGGACGTC       GGCCCCCGGCCCCCCAGCAGCCTCCAAAGCCCTGTGACTCACAGCCCTGCTTCCACGGGGGGACCTGC       CAGGACTGGGCATTGGGCGGGGGCTTCACCTGCAGCTGCCCGGCAGGCAGGGGAGGCGCCGTCTGTGA       GAAGGTGCTTGGCGCCCCTGTGCCGGCCTTCGAGGGCCGCTCCTTCCTGGCCTTCCCCACCCTCCGCG       CCTACCACACGCTGCGCCTGGCACTGGAATTCCGGGCGCTGGAGCCTCAGGGGCTGCTGCTGTACAAT       GGCAACGCCCGGGGCAAGGACTTCCTGGCATTGGCGCTGCTAGATGGCCGCGTGCAGCTCAGGTTTGA       CACAGGTTCGGGGCCGGCGGTGCTGACCAGTGCCGTGCCGGTAGAGCCGGGCCAGTGGCACCGCCTGG       AGCTGTCCCGGCACTGGCGCCGGGGCACCCTCTCGGTGGATGGTGAGACCCCTGTTCTGGGCGAGAGT       CCCAGTGGCACCGACGGCCTCAACCTGGACACAGACCTCTTTGTGGGCGGCGTACCCGAGGACCAGGC       TGCCGTGGCGCTGGAGCGGACCTTCGTGGGCGCCGGCCTGAGGGGGTGCATCCGTTTGCTGGACGTCA       ACAACCAGCGCCTGGAGCTTGGCATTGGGCCGGGGGCTGCCACCCGAGGCTCTGGCGTGGGCGAGTGC       GGGGACCACCCCTGCCTGCCCAACCCCTGCCATGGCGGGGCCCCATGCCAGAACCTGGAGGCTGGAAG       GTTCCATTGCCAGTGCCCGCCCGGCCGCGTCGGACCAACCTGTGCCGATGAGAAGAGCCCCTGCCAGC       CCAACCCCTGCCATGGGGCGGCGCCCTGCCGTGTGCTGCCCGAGGGTGGTGCTCAGTGCGAGTGCCCC       CTGGGGCGTGAGGGCACCTTCTGCCAGACAGCCTCGGGGCAGGACGGCTCTGGGCCCTTCCTGGCTGA       CTTCAACGGCTTCTCCCACCTGGAGCTGAGAGGCCTGCACACCATTGCACGGGACCTGGGGGAGAAGA       TGGCGCTGGAGGCCGTGTTCCTGGCACGAGGCCCCAGCGGCCTCCTGCTCTACAACGGGCAGAAGACG       GACGGCAAGGGGGACTTCGTGTCGCTGGCACTGCGGGACCGCCGCCTGGAGTTCCGCTACGACCTGGG       CAAGGGGGCAGCGGTCATCAGGAGCAGGGAGCCAGTCACCCTGGGAGCCTGGACCAGGGTCTCACTGG       AGCGAAACGGCCGCAAGGGTGCCCTGCGTGTGGGCGACGGCCCCCGTGTGTTGGGGGAGTCCCCGAAA       TCCCGCAAGGTTCCGCACACCGTCCTCAACCTGAAGGAGCCGCTCTACGTAGGGGGCGCTCCCGACTT       CAGCAAGCTGGCCCGTGCTGCTGCCGTGTCCTCTGGCTTCGACGGTGCCATCCAGCTGGTCTCCCTCG       GAGGCCGCCAGCTGCTGACCCCGGAGCACGTGCTGCGGCAGGTGGACGTCACGTCCTTTGCAGGTCAC       CCCTGCACCCGGGCCTCAGGCCACCCCTGCCTCAATGGGGCCTCCTGCGTCCCGAGGGAGGCTGCCTA       TGTGTGCCTGTGTCCCGGGGGATTCTCAGGACCGCACTGCGAGAAGGGGCTGGTGGAGAAGTCAGCGG       GGGACGTGGATACCTTGGCCTTTGACGGGCGGACCTTTGTCGAGTACCTCAACGCTGTGACCGAGAGC       GAGAAGGCACTGCAGAGCAACCACTTTGAACTGAGCCTGCGCACTGAGGCCACGCAGGGGCTGGTGCT       CTGGAGTGGCAAGGCCACGGAGCGGGCAGACTATGTGGCACTGGCCATTGTGGACGGGCACCTGCAAC       TGAGCTACAACCTGGGCTCCCAGCCCGTGGTGCTGCGTTCCACCGTGCCCGTCAACACCAACCGCTGG       TTGCGGGTCGTGGCACATAGGGAGCAGAGGGAAGGTTCCCTGCAGGTGGGCAATGAGGCCCCTGTGAC       CGGCTCCTCCCCGCTGGGCGCCACGCAGCTGGACACTGATGGAGCCCTGTGGCTTGGTGAGTGTTTTG       GGGAGACTAGAGAGGGATGCCCAAGGGTCTCAGATATCCGAGGGACAGACTCCACCCCCCAGCGCCCA       CCCTTGAGTCAGGGTGCATGTGAGCCGGCGGGCTGGGCTCTCTTCTCCCGCTGTAGCCCCTGCAGTTC       CCAGTGCTGTGGGGCCGGGAGGCGGGTGCCCAGGTGTGGGCCCCCTGCTGGTCACCTGCTCGTTGGGG       TGCCCATCAGCATCACTGAGTCACAGCCGGGTGACTCCCACTGTCTGTGCTGCAGGGGCCTGCCGGAG       CTGCCCGTGGGCCCAGCACTGCCCAAGGCCTACGGCACAGGCTTTGTGGGCTGCTTGCGGGATGTGGT       GGTGGGCCGGCACCCGCTGCACCTGCTGGAGGACGCCGTCACCAAGCCAGAGCTGCGGCCCTGCCCCA       CCCCA TGA   GCTGGCACCAGAGCCCCGCGCCCGCT                                                   NOV60h, CG94946-06   SEQ ID NO: 1188   2143 aa   MW at 225054.6kD               Protein Sequence                     MRHGRPVPPGPAAGRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTY           SCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNEL       MLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKS       PCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTA       SCLCPATCRGAPEGTVCGSDGADYPGECQLLRPACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPR       TRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAV       CLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQ       CAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQC       RFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCA       FGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGS       GEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYV       AAQGACRGPAFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQC       SCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQC       PDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNEC       QLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQT       TPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGG       LEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTP       EMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVA       RALLRQIQVSRRRSLGVRRPLQENVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRA       PHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCS       CPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALA       LLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTD       LFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHG       GAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTAS       GQDGSGPFLADFNGFSHLELRGLHTIARDLGEKMALEAVFLARGPSGLLLYNGQKTDGKGDFVSLALR       DRRIEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLK       EPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLN       GASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESEKALQSNHFELS       LRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREG       SLQVGNEAPVTGSSPLGATQLDTDGALWLGECFGETREGCPRVSDIRGTDSTPQRPPLSQGACEPAGW       ALFSRCSPCSSQCCGAGRRVPRCGPPAGHLLVGVPISITESQPGDSHCLCCRGLPELPVGPALPKAYG       TGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP                                             NOV60i, CG94946-07   SEQ ID NO: 1189   5688 bp               DNA Sequence   ORF Start: ATG at 37   ORF Stop: TGA at 4735                       CCGGCGCGGCCCGCGCGCTCTTCCGCCGCCTCTCGC   ATG CGCCATGGCCGGCCGGTCCCACCCGGGCC           CGCTGCGGGGCGGCCGCTGCTGCCTCTCCTTGTGGTGGCCGCGTGCGTCCTGCCCGGAGCCGGCGGGA       CATGCCCGGAGCGCGCGCTGGAGCGGCGCGAGGAGGAGGCGAACGTGGTGCTCACCGGGACGGTGGAG       GAGATCCTCAACGTGGACCCGGTGCAGCACACGTACTCCTGCAAGGTTCGGGTCTGGCGGTACTTGAA       GGGCAAAGACCTGGTGGCCCGGGAGAGCCTGCTGGACGGCGGCAACAAGGTGGTGATCAGCGGCTTTG       GAGACCCCCTCATCTGTGACAACCAGGTGTCCACTGGGGACACCAGGATCTTCTTTGTGAACCCTGCA       CCCCCATACCTGTGGCCAGCCCACAAGAACGAGCTGATGCTCAACTCCAGCCTCATGCGGATCACCCT       GCGGAACCTGGAGGAGGTGGAGTTCTGTGTGGAAGATAAACCCGGGACCCACTTCACTCCAGTGCCTC       CGACGCCTCCTGATGCGTGCCGGGGAATGCTGTGCGGCTTCGGCGCCGTGTGCGAGCCCAACGCGGAG       GGGCCGGGCCGGGCGTCCTGCGTCTGCAAGAAGAGCCCGTGCCCCAGCGTGGTGGCGCCTGTGTGTGG       GTCGGACGCCTCCACCTACAGCAACGAATGCGAGCTGCAGCGGGCGCAGTGCAGCCAGCAGCGCCGCA       TCCGCCTGCTCAGCCGCGGGCCGTGCGGCTCGCGGGACCCCTGCTCCAACGTGACCTGCAGCTTCGGC       AGCACCTGTGCGCGCTCGGCCGACGGGCTGACGGCCTCGTGCCTGTGCCCCGCGACCTGCCGTGGCGC       CCCCGAGGGGACCGTCTGCGGCAGCGACGGCGCCGACTACCCCGGCGAGTGCCAGCTCCTGCGCCGCG       CCTGCGCCCGCCAGGAGAATGTCTTCAAGAAGTTCGACGGCCCTTGTGACCCCTGTCAGGGCGCCCTC       CCTGACCCGAGCCGCAGCTGCCGTGTGAACCCGCGCACGCGGCGCCCTGAGATGCGCCTACGGCCCGA       GAGCTGCCCTGCCCGGCAGGCGCCAGTGTGTGGGGACGACGGAGTCACCTACGAAAACGACTGTGTCA       TGGGCCGATCGGGGGCCGCCCGGGGTCTCCTCCTGCAGAAAGTGCGCTCCGGCCAGTGCCAGGGTCGA       GACCAGTGCCCGGAGCCCTGCCGGTTCAATGCCGTGTGCCTGTCCCGCCGTGGCCGTCCCCGCTGCTC       CTGCGACCGCGTCACCTGTGACGGGGCCTACAGGCCCGTGTGTGCCCAGGACGGGCGCACGTATGACA       GTGATTGCTGGCGGCAGCAGGCTGAGTGCCGGCAGCAGCGTGCCATCCCCAGCAAGCACCAGGGCCCG       TGTGACCAGGCCCCGTCCCCATGCCTCGGGGTGCAGTGTGCATTTGGGGCGACGTGTGCTGTGAAGAA       CGGGCAGGCAGCGTGTGAATGCCTGCAGGCGTGCTCGAGCCTCTACGATCCTGTGTGCGGCAGCGACG       GCGTCACATACGGCAGCGCGTGCGAGCTGGAGGCCACGGCCTGTACCCTCGGGCGGGAGATCCAGGTG       GCGCGCAAAGGACCCTGTGACCGCTGCGGGCAGTGCCGCTTTGGAGCCCTGTGCGAGGCCGAGACCGG       GCGCTGCGTGTGCCCCTCTGAATGCGTGGCTTTGGCCCAGCCCGTGTGTGGCTCCGACGGGCACACGT       ACCCCAGCGAGTGCATGCTGCACGTGCACGCCTGCACACACCAGATCAGCCTGCACGTGGCCTCAGCT       GGACCCTGCGAGACCTGTGGAGATGCCGTGTGTGCTTTTGGGGCTGTGTGCTCCGCAGGGCAGTGTGT       GTGTCCCCGGTGTGAGCACCCCCCGCCCGGCCCCGTGTGTGGCAGCGACGGTGTCACCTACGGCAGTG       CCTGCGAGCTACGGGAAGCCGCCTGCCTCCAGCAGACACAGATCGAGGAGGCCCGGGCAGGGCCGTGC       GAGCAGGCCGAGTGCGGTTCCGGAGGCTCTGGCTCTGGGGAGGACGGTGACTGTGAGCAGGAGCTGTG       CCGGCAGCGCGGTGGCATCTGGGACGAGGACTCGGAGGACGGGCCGTGTGTCTGTGACTTCAGCTGCC       AGAGTGTCCCAGGCAGCCCGGTGTGCGGCTCAGATGGGGTCACCTACAGCACCGAGTGTGAGCTGAAG       AAGGCCAGGTGTGAGTCACAGCGAGGGCTCTACGTAGCGGCCCAGGGAGCCTGCCGAGGCCCCACCTT       CGCCCCGCTGCCGCCTGTGGCCCCCTTACACTGTGCCCAGACGCCCTACGGCTGCTGCCAGGACAATA       TCACCGCAGCCCGGGGCGTGGGCCTGGCTGGCTGCCCCAGTGCCTGCCAGTGCAACCCCCATGGCTCT       TACGGCGGCACCTGTGACCCAGCCACAGGCCAGTGCTCCTGCCGCCCAGGTGTGGGGGGCCTCAGGTG       TGACCGCTGTGAGCCTGGCTTCTGGAACTTTCGAGGCATCGTCACCGATGGCCGGAGTGGCTGTACAC       CCTGCAGCTGTGATCCCCAAGGCGCCGTGCGGGATGACTGTGAGCAGATGACGGGGCTGTGCTCGTGT       AAGCCCGGGGTGGCTGGACCCAAGTGTGGGCAGTGTCCAGACGGCCGTGCCCTGGGCCCCGCGGGCTG       TGAAGCTGACGCTTCTGCGCCTGCGACCTGTGCGGAGATGCGCTGTGAGTTCGGTGCGCGGTGCGTGG       AGGAGTCTGGCTCAGCCCACTGTGTCTGCCCGATGCTCACCTGTCCAGAGGCCAACGCTACCAAGGTC       TGTGGGTCAGATGGAGTCACATACGGCAACGAGTGTCAGCTGAAGACCATCGCCTGCCGACGGTGTCA       CCTACGCCAGGGCCTGCAAATCTCTATCCAGAGCCTGGGCCCGTGCCAGGAGGCTGTTGCTCCCAGCA       CTCACCCGACATCTGCCTCCGTGACTGTGACCACCCCAGGGCTCCTCCTGAGCCAGGCACTGCCGGCC       CCCCCCGGCGCCCTCCCCCTGGCTCCCAGCAGTACCGCACACAGCCAGACCACCCCTCCGCCCTCATC       GCGACCTCGGACCACTGCCAGCGTCCCCAGGACCACCGTGTGGCCCGTGCTGACGGTGCCCCCCACGG       CACCCTCCCCTGCACCCAGCCTGGTGGCGTCCGCCTTTGGTGAATCTGGCAGCACTGATGGAAGCAGC       GATGAGGAACTGAGCGGGGACCAGGAGGCCAGTGGGGGTGGCTCTGGGGGGCCCGAGCCCTTGGAGGG       CAGCAGCGTGGCCACCCCTGGGCCACCTGTCGAGAGGGCTTCCTGCTACAACCCCTGCCATGGGGCGG       CGCCCTGCCGTGTGCTGCCCGAGGGTGGTGCTCAGTGCGAGTGCCCCCTGGGGCGTGAGGGCACCTTC       TGCCAGACAGCCTCGGGGCAGGACGGCTCTGGGCCCTTCCTGGCTGACTTCAACGGCTTCTCCCACCT       GGAGCTGAGAGGCCTGCACACCTTTGCACGGGACCTGGGGGAGAAGATGGCGCTGGAGGTCGTGTTCC       TGGCACGAGGCCCCAGCGGCCTCCTGCTCTACAACGGGCAGAAGACGGACGGCAAGGGGGACTTCGTG       TCGCTGGCACTGCGGGACCGCCGCCTGGAGTTCCGCTACGACCTGGGCAAGGGGGCAGCGGTCATCAG       GAGCAGGGAGCCAGTCACCCTGGGAGCCTGGACCAGGGTCTCACTGGAGCGAAACGGCCGCAAGGGTG       CCCTGCGTGTGGGCGACGGCCCCCGTGTGTTGGGGGAGTCCCCGGTTCCGCACACCGTCCTCAACCTG       AAGGAGCCGCTCTACGTAGGGGGCGCTCCCGACTTCAGCAAGCTGGCCCGTGCTGCTGCCGTGTCCTC       TGGCTTCGACGGTGCCATCCAGCTGGTCTCCCTCGGAGGCCGCCAGCTGCTGACCCCGGAGCACGTGC       TGCGGCAGGTGGACGTCACGTCCTTTGCAGGTCACCCCTGCACCCGGGCCTCAGGCCACCCCTGCCTC       AATGGGGCCTCCTGCGTCCCGAGGGAGGCTGCCTATGTGTGCCTGTGTCCCGGGGGATTCTCAGGACC       GCACTGCGAGAAGGGGCTGGTGGAGAAGTCAGCGGGGGACGTGGATACCTTGGCCTTTGACGGGCGGA       CCTTTGTCGAGTACCTCAACGCTGTGACCGAGAGCGAGAAGGCACTGCAGAGCAACCACTTTGAACTG       AGCCTGCGCACTGAGGCCACGCAGGGGCTGGTGCTCTGGAGTGGCAAGGCCACGGAGCGGGCAGACTA       TGTGGCACTGGCCATTGTGGACGGGCACCTGCAACTGAGCTACAACCTGGGCTCCCAGCCCGTGGTGC       TGCGTTCCACCGTGCCCGTCAACACCAACCGCTGGTTGCGGGTCGTGGCACATAGGGAGCAGAGGGAA       GGTTCCCTGCAGGTGGGCAATGAGGCCCCTGTGACCGGCTCCTCCCCGCTGGGCGCCACGCAGCTGGA       CACTGATGGAGCCCTGTGGCTTGGGGGCCTGCCGGAGCTGCCCGTGGGCCCAGCACTGCCCAAGGCCT       ACGGCACAGGCTTTGTGGGCTGCTTGCGGGATGTGGTGGTGGGCCGGCACCCGCTGCACCTGCTGGAG       GACGCCGTCACCAAGCCAGAGCTGCGGCCCTGCCCCACCCCA TGA   GCTGGCACCAGAGCCCCGCGCCC           GCTGTAATTATTTTCTATTTTTGTAAACTTGTTGCTTTTTGATATGATTTTCTTGCCTGAGTGTTGGC           CGGAGGGACTGCTGGCCCGGCCTCCCTTCCGTCCAGGCAGCCGTGCTGCAGACAGACCTAGTGCTGAG           GGATGGACAGGCGAGGTGGCAGCGTGGAGGGCTCGGCGTGGATGGCAGCCTCAGGACACACACCCCTG           CCTCAAGGTGCTGAGCCCCCGCCTTGCACTGCGCCTGCCCCACGGTGTCCCCGCCGGGAAGCAGCCCC           GGCTCCTGAATCACCCTCGCTCCGTCAGGCGGGACTCGTGTCCCAAAAAGGAAGGGGCTGCTGAGGTC           TGATGGGGCCCTTCCTCCGGGTGACCCCACAGGGCCTTTCCAAGCCCCTATTTGAGCTGCTCCTTCCT           GTGTGTGCTCTGGACCCTGCCTCGGCCTCCTGCGCCAATACTGTGACTTCCAAACAATGTTACTGCTG           GGCACAGCTCTGCGTTGCTCCCGTGCTGCCTGCGCCAGCCCCAGGCTGCTGAGGAGCAGAGGCCAGAC           CAGGGCCGATCTGGGTGTCCTGACCCTCAGCTGGCCCTGCCCAGCCACCCTGGACATGACCGTATCCC           TCTGCCACACCCCAGGCCCTGCGAGGGGCTATCGAGAGGAGCTCACTGTGGGATGGGGTTGACCTCTG           CCGCCTGCCTGGGTATCTGGGCCTGGCCATGGCTGTGTTCTTCATGTGTTGATTTTATTTGACCCCTG           GAGTGGTGGGTCTCATCTTTCCCATCTCGCCTGAGAGCGGCTGAGGGCTGCCTCACTGCAAATCCTCC           CCACAGCGTCAGTGAAAGTCGTCCTTGTCTCAGAATGACCAGGGGCCAGCCAGTGTCTGACCAAGGTC           AAGGGGCAGGTGCAGAGGTGGCAGGGATGGCTCCGAAGCCAGAA                                                   NOV60i, CG94946-07   SEQ ID NO: 1190   1566 aa   MW at 164102.4kD               Protein Sequence                     MRHGRPVPPGPAAGRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTY           SCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNEL       MLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKS       PCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTA       SCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPR       TRRPEMRLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAV       CLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQ       CAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQC       RFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCA       FGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGS       GEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYV       AAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQC       SCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQC       PDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNEC       QLKTIACRRCHLRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSST       AHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASG       GGSGGPEPLEGSSVATPGPPVERASCYNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGP       FLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFR       YDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTVLNLKEPLYVGGAPDF       SKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAY       VCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESEKALQSNHFELSLRTEATQGLVL       WSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVT       GSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCP       TP                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 60B.  
               TABLE 60B                       Comparison of the NOV60 protein sequences.                                        NOV60a ------------------------------------------------------------           NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g MRHGRPVPPGPAAGRPLLPLLVVAACVLPGAGGTCPERALERREEEAINVLTGTVEEILN       NOV60h ------------------------------------------------------------       NOV60i ------------------------------------------------------------               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g VDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFF       NOV60h ------------------------------------------------------------       NOV60i ------------------------------------------------------------               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g VNPAPPYLWPAHKNELMLNSSLNRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGML       NOV60h ------------------------------------------------------------       NOV60i ------------------------------------------------------------               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g CGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRL       NOV60h ------------------------------------------------------------       NOV60i ------------------------------------------------------------               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g LSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGEC       NOV60h ------------------------------------------------------------       NOV60i ------------------------------------------------------------               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g QLLRPACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPV       NOV60h ------------------------------------------------------------       NOV60i ------------------------------------------------------------               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g CGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSC       NOV60h ------------------------------------------------------------       NOV60i ------------------------------------------------------------               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ----------------------MRHGRPVPPGPAAGRPLLPLLVVAACVLPGAGGTCPER       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g DRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFG       NOV60h ------------------------------------------------------------       NOV60i ----------------------MRHGRPVPPGPAAGRPLLPLLVVAACVLPGAGGTCPER               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGNKVVI       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDR       NOV60h ------------------------------------------------------------       NOV60i ALERREEEAIWVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGNKVVI               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d SGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVE       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g CGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASA       NOV60h ------------------------------------------------------------       NOV60i SGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVE               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d DKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDA       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g GPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQI       NOV60h ------------------------------------------------------------       NOV60i DKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDA               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d STYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPA       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g EEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSP       NOV60h ------------------------------------------------------------       NOV60i STYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPA               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d TCRGAPEGTVCGSDGADYPGECQLLREACARQENVFKKFDGPCDPCQGALPDPSRSCRVN       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g VCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPAFAPLPPVAPLHCAQTPYGCCQD       NOV60h ------------------------------------------------------------       NOV60i TCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVN               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d PRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQ       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g NITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGI       NOV60h ------------------------------------------------------------       NOV60i PRTRRPEMRLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQ               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d CPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIP       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g VTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADAS       NOV60h ------------------------------------------------------------       NOV60i CPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIP               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d SKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACE       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g APATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACR       NOV60h ------------------------------------------------------------       NOV60i SKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACE               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d LEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTY       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g QGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQT       NOV60h ------------------------------------------------------------       NOV60i LEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTY               NOV60a --------------------------------MRHGRPVPPGPAAGRPLLPLLVVAACVL       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d PSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGS       NOV60e --------------------------------MRHGRPVPPGPAAGRPLLPLLVVAACVL       NOV60f --------------------------------MRHGRPVPPGPAAGRPLLPLLVVAACVL       NOV60g TPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQE       NOV60h --------------------------------MRHGRPVPPGPAAGRPLLPLLVVAACVL       NOV60i PSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGS               NOV60a PGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARES       NOV60b --------------------------------------------------TGSATKVFQG       NOV60c ------------------------------------------------------------       NOV60d DGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIW       NOV60e PGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARES       NOV60f PGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARES       NOV60g ASGGGSGGLEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQG       NOV60h PGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARES       NOV60i DGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIW               NOV60a LLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLR       NOV60b VLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLG-       NOV60c ------------------------------------------------------------       NOV60d DEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPA       NOV60e LLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELVLWSG-------       NOV60f LLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLR       NOV60g VLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLG-       NOV60h LLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLR       NOV60i DEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPT               NOV60a NLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPS       NOV60b --------------------------------PGKSVRAIVDVHFDP-------------       NOV60c -----------------------------------TGSCQCNPHG---------------       NOV60d FAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHG---------------       NOV60e ---------------K------------ATERADYVALAIVDGHLQ--------------       NOV60f NLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPS       NOV60g --------------------------------PGKSVRAIVDVHFDP-------------       NOV60h NLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPS       NOV60i FAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHG---------------               NOV60a VVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSAD       NOV60b ----------TTAFRAPDVARALLRQIQVS------------------------------       NOV60c -----------SYGGTCDPATGQCS-----------------------------------       NOV60d -----------SYGGTCDPATGQCS-----------------------------------       NOV60e ----------LSYNLGSQPVVLRST-----------------------------------       NOV60f VVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSAD       NOV60g ----------TTAFRAPDVARALLRQIQVS------------------------------       NOV60h VVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSAD       NOV60i -----------SYGGTCDPATGQCS-----------------------------------               NOV60a GLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRPACARQENVFKKFDGPCDPCQGAL       NOV60b ------------RRRSLGVRRP-----------------LQEHVRFMDFDWVDG------       NOV60c -----------CRPGVGGLRCD------------------RCEPGFWNFRG---------       NOV60d -----------CRPGVGGLRCD------------------RCEPGFWNFRG---------       NOV60e -------------VPVNTNRWL------------------RVVAHREQREG---------       NOV60f GLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGAL       NOV60g ------------RRRSLGVRRP-----------------LQEHVRFMDFDWFPAFITGAT       NOV60h GLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGAL       NOV60i -----------CRPGVGGLRCD------------------RCEPGFWNFRG---------               NOV60a PDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKV       NOV60b ------------------------------------------------------------       NOV60c -------------------------------IVTD-----------GRS-----------       NOV60d -------------------------------IVTD-----------GRS-----------       NOV60e -----------------------------SLQVGN-------------------------       NOV60f PDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKV       NOV60g SGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGR       NOV60h PDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKV       NOV60i -------------------------------IVTD-----------GRS-----------               NOV60a RSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQ       NOV60b ------------------------------------------------------------       NOV60c -------------------------GCTPCSCD---PQGAVRDDCEQ-------------       NOV60d -------------------------GCTPCSCD---PQGAVRDDCEQ-------------       NOV60e---------------------------EAPVTGS--SPLGATQLDTDG-------------       NOV60f RSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQ       NOV60g RPPASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESEK       NOV60h RSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQ       NOV60i -------------------------GCTPCSCD---PQGAVRDDCEQ-------------               NOV60a AECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGS       NOV60b ------------------------------------------------------------       NOV60c ------------------------------MTGLCSCKPG----------------VAG-       NOV60d ------------------------------MTGLCSCKPG----------------VAG-       NOV60e ---------------------------ALWLGGLPELPVG--------------------       NOV60f AECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGS       NOV60g ALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVP       NOV60h AECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGS       NOV60i ------------------------------MTGLCSCKPG----------------VAG-               NOV60a DGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQ       NOV60b ------------------------------------------------------------       NOV60c ------------------------------PKCGQC------------------------       NOV60d ------------------------------PKCGQC------------------------       NOV60e ------------------------------------------------------------       NOV60f DGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRF----------------------       NOV60g VNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALP       NOV60h DGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQ       NOV60i ------------------------------PKCGQC------------------------               NOV60a PVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCE       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g KAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP---------------------       NOV60h PVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCE       NOV60i ------------------------------------------------------------               NOV60a HPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQ       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h HPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQ       NOV60i ------------------------------------------------------------               NOV60a ELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYV       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h ELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYV       NOV60i ------------------------------------------------------------               NOV60a AAQGACRGPAFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGT       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h AAQGACRGPAFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGT       NOV60i ------------------------------------------------------------               NOV60a CDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTG       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h CDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTG       NOV60i ------------------------------------------------------------               NOV60a LCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCP       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h LCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCP       NOV60i ------------------------------------------------------------               NOV60a MLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASV       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h MLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASV       NOV60i ------------------------------------------------------------               NOV60a TVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPT       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h TVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPT       NOV60i ------------------------------------------------------------               NOV60a APSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVEEAS       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h APSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERAS       NOV60i ------------------------------------------------------------               NOV60a CYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGE       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h CYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGE       NOV60i ------------------------------------------------------------               NOV60a TARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVEAIVDVHFDPTTAFRAPDVAEALL       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h TARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVEAIVDVHFDPTTAFRAPDVARALL       NOV60i ------------------------------------------------------------               NOV60a RQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAV       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h RQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAV       NOV60i ------------------------------------------------------------               NOV60a TPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTC       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h TPRAPHPSHTSQPVAXTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTC       NOV60i ------------------------------------------------------------               NOV60a QDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALE       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h QDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALE       NOV60i ------------------------------------------------------------               NOV60a PQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWR       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h PQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWR       NOV60i ------------------------------------------------------------               NOV60a RGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLD       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h RGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLD       NOV60i ------------------------------------------------------------               NOV60a VNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPT       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h VNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPT       NOV60i ------------------------------------------------------------               NOV60a CADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFS       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h CADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFS       NOV60i ------------------------------------------------------------               NOV60a HLELRGLHTIARDLGEKMALEAVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRY       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h HLELRGLHTIARDLGEKMALEAVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRY       NOV60i ------------------------------------------------------------               NOV60a DLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLK       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h DLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLK       NOV60i ------------------------------------------------------------               NOV60a EPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEBVLRQVDVTSFAGHPCTR       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h EPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTR       NOV60i ------------------------------------------------------------               NOV60a ASGHPCLNGASCVPREAAYSICLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNA       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h ASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNA       NOV60i ------------------------------------------------------------               NOV60a VTESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVV       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h VTESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVV       NOV60i ------------------------------------------------------------               NOV60a LRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWL-------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f -----------------------------GALPVTGSSPLGATQLDTDGALWL-------       NOV60g ------------------------------------------------------------       NOV60h LRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGECFGET       NOV60i ------------------------------------------------------------               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ------------------------------------------------------------       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h REGCPRVSDIRGTDSTPQRPPLSQGACEPAGWALFSRCSPCSSQCCGAGRRVPRCGPPAG       NOV60i ------------------------------------------------------------               NOV60a -----------------------GGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLL       NOV60b ------------------------------------------------------------       NOV60c -----------------------------------PDGRALGPAGCVDG-----------       NOV60d -----------------------------------PDGRALGPAGCEADASAPATCAEMR       NOV60e --------------------------------PALPKAYGTGFVGCLRDVVVGRHPLHLL       NOV60f -----------------------GGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLL       NOV60g ------------------------------------------------------------       NOV60h HLLVGVPISITESQPGDSHCLCCRGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLL       NOV60i -----------------------------------PDGRALGPAGCEADASAPATCAENR               NOV60a EDAVTKPELRPCPTP---------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d CEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQS       NOV60e EDAVTKPELRPCPTP---------------------------------------------       NOV60f EDAVTKPELRPCPTP---------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h EDAVTKPELRPCPTP---------------------------------------------       NOV60i CEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRRCHLRQGLQ               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d LGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPR       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h ------------------------------------------------------------       NOV60i ISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPP               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d TTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGL       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h ------------------------------------------------------------       NOV60i SSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGG               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d EPLEGSSVATPGPPVERASCYNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGS       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h ------------------------------------------------------------       NOV60i GSGGPEPLEGSSVATPGPPVERASCYNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTAS               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d GPFLADFNGFSHLELRGLHTIARDLGEKMALEAVFLARGPSGLLLYNGQKTDGKGDFVSL       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h ------------------------------------------------------------       NOV60i GQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKG               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d ALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKS       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h ------------------------------------------------------------       NOV60i DFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLG               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d RKVPHTVLNLKEPLYVGGAPDFSKLAPAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVD       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h ------------------------------------------------------------       NOV60i ESPVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQV               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d VTSFAGHPCTPASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAF       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h ------------------------------------------------------------       NOV60i DVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLA               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d DGRTFVEYLNAVTESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQ       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h ------------------------------------------------------------       NOV60i FDGRTFVEYLNAVTESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHL               NOV60a ------------------------------------------------------------       NOV60b ------------------------------------------------------------       NOV60c ------------------------------------------------------------       NOV60d LSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDG       NOV60e ------------------------------------------------------------       NOV60f ------------------------------------------------------------       NOV60g ------------------------------------------------------------       NOV60h ------------------------------------------------------------       NOV60i QLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTD               NOV60a ---------------------------------------------------------       NOV60b ---------------------------------------------------------       NOV60c ---------------------------------------------------------       NOV60d ALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP-       NOV60e ---------------------------------------------------------       NOV60f ---------------------------------------------------------       NOV60g ---------------------------------------------------------       NOV60h ---------------------------------------------------------       NOV60i GALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP               NOV60a (SEQ ID NO: 1174)       NOV60b (SEQ ID NO: 1176)       NOV60c (SEQ ID NO: 1178)       NOV60d (SEQ ID NO: 1180)       NOV60e (SEQ ID NO: 1182)       NOV60f (SEQ ID NO: 1184)       NOV60g (SEQ ID NO: 1186)       NOV60h (SEQ ID NO: 1188)       NOV60i (SEQ ID NO: 1190)                  
 
      Further analysis of the NOV60a protein yielded the following properties shown in Table 60C.  
               TABLE 60C                       Protein Sequence Properties NOV60a                                        SignalP analysis:   Cleavage site between residues 34 and 35       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 5; pos. chg 2; neg. chg 0           H-region:   length 9; peak value 3.79           PSG score:   −0.61                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 0.49           possible cleavage site: between 33 and 34                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 17-33               −4.35                             PERIPHERAL   Likelihood = 0.53 (at 609)                         ALOM score: −4.35 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 24           Charge difference: −6.5 C(−2.0)-N(4.5)           N &gt;= C: N-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 2 (cytoplasmic tail 1 to 17)                     MITDISC:   discrimination of mitochondrial targeting seg                                     R content:    3   Hyd Moment(75):   2.17           Hyd Moment(95):   10.07   G content:   6           D/E content:    1   S/T content:   1                         Score: −4.90       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-2 motif at 25 GRP|LL                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: PRTRRPE (5) at 339           pat7: PKSRKVP (5) at 1755           bipartite: none           content of basic residues: 9.5%           NLS Score: 0.39       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         XXRR-like motif in the N-terminus: RHGR                 none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: none       Dileucine motif in the tail: none       checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: nuclear           Reliability: 76.7       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         34.8%: mitochondrial           34.8%: nuclear           13.0%: cytoplasmic            4.3%: extracellular, including cell wall            4.3%: vacuolar            4.3%: Golgi            4.3%: peroxisomal                 &gt;&gt; prediction for CG94946-01 is mit (k = 23)                  
 
      A search of the NOV60a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 60D.  
               TABLE 60D                          Geneseq Results for NOV60a                                         NOV60a   Identities/               Protein/Organism/Length   Residues/   Similarities for       Geneseq   [Patent #,   Match   the Matched   Expect       Identifier   Date]   Residues   Region   Value                                             ABU52400   Human GPCR related protein   160 . . . 2053   1841/1894   (97%)   0.0           NOV40a -  Homo sapiens , 1931 aa.    51 . . . 1931   1853/1894   (97%)           [WO200279398-A2, 10-OCT-2002]       ABP43859   Human mRNA precursor -  Homo     137 . . . 1669   1530/1533   (99%)   0.0             sapiens , 1741 aa. [WO200231111-    1 . . . 1533   1530/1533   (99%)           A2, 18-APR-2002]       AAW26609   Human agrin -  Homo sapiens , 492   1591 . . . 2053    460/471   (97%)   0.0           aa. [WO9721811-A2, 19-JUN-1997]   22 . . . 492   461/471   (97%)       AAB93754   Human protein sequence SEQ ID   583 . . . 968    381/386   (98%)   0.0           NO: 13424 -  Homo sapiens , 413 aa.    1 . . . 386   384/386   (98%)           [EP1074617-A2, 07-FEB-2001]       AAY73993   Human prostate tumor EST fragment   1634 . . . 2053    414/420   (98%)   0.0           derived protein #180 -  Homo sapiens ,    1 . . . 416   414/420   (98%)           416 aa. [DE19820190-A1, 04-NOV-1999]                  
 
      In a BLAST search of public sequence databases, the NOV60a protein was found to have homology to the proteins shown in the BLASTP data in Table 60E.  
               TABLE 60E                          Public BLASTP Results for NOV60a                                         NOV60a               Protein       Residues/   Identities/       Accession       Match   Similarities for the   Expect       Number   Protein/Organism/Length   Residues   Matched Portion   Value                                             O00468   AGRIN precursor -  Homo sapiens     24 . . . 2053    2022/2030   (99%)   0.0           (Human), 2026 aa (fragment).   1 . . . 2026   2022/2030   (99%)       P25304   Agrin precursor -  Rattus     160 . . . 2053    1558/1914   (81%)   0.0             norvegicus  (Rat), 1959 aa.   51 . . . 1959    1663/1914   (86%)       P31696   Agrin precursor -  Gallus gallus     128 . . . 2050    1234/1970   (62%)   0.0           (Chicken), 1955 aa.   1 . . . 1952   1479/1970   (74%)       Q90404   Agrin -  Discopyge ommata     716 . . . 2051    733/1353   (54%)   0.0           (Electric ray), 1328 aa (fragment).   1 . . . 1325   932/1353   (68%)       Q96IC1   Hypothetical protein -  Homo     1562 . . . 2053     486/492   (98%)   0.0             sapiens  (Human), 488 aa   1 . . . 488    486/492   (98%)           (fragment).                  
 
      PFam analysis predicts that the NOV60a protein contains the domains shown in the Table 60F.  
               TABLE 60F                          Domain Analysis of NOV60a                                     Identities/           Pfam   NOV60a   Similarities for   Expect       Domain   Match Region   the Matched Region   Value                                         NtA    34 . . . 161   125/135   (93%)   1.1e−111               128/135   (95%)       kazal   201 . . . 246   25/61   (41%)   7.2e−18               36/61   (59%)       kazal   276 . . . 321   21/62   (34%)   5.1e−13               33/62   (53%)       kazal   346 . . . 393   18/61   (30%)   7.9e−12               33/61   (54%)       kazal   420 . . . 465   21/61   (34%)   4.1e−16               38/61   (62%)       kazal   494 . . . 538   24/61   (39%)   3.6e−19               38/61   (62%)       kazal   559 . . . 603   19/61   (31%)   1.4e−18               38/61   (62%)       kazal   624 . . . 668   26/62   (42%)   1.5e−17               37/62   (60%)       kazal   709 . . . 754   24/62   (39%)   1.2e−16               40/62   (65%)       laminin_EGF   797 . . . 848   28/61   (46%)   1.1e−20               46/61   (75%)       laminin_EGF   851 . . . 895   21/59   (36%)   3.6e−11               37/59   (63%)       kazal   927 . . . 973   25/62   (40%)   5.2e−18               41/62   (66%)       SEA   1134 . . . 1256   38/132   (29%)   4.6e−37               111/132   (84%)       EGF   1337 . . . 1370   16/47   (34%)   0.00055               24/47   (51%)       laminin_G   1404 . . . 1535   71/155   (46%)   7.4e−55               120/155   (77%)       EGF   1557 . . . 1589   16/47   (34%)   5.2e−06               27/47   (57%)       EGF   1596 . . . 1628   16/47   (34%)   0.00021               25/47   (53%)       laminin_G   1672 . . . 1807   70/155   (45%)   7e−52               123/155   (79%)       EGF   1826 . . . 1860   14/47   (30%)   4.3e−07               25/47   (53%)       laminin_G   1905 . . . 2036   59/155   (38%)   2e−50               125/155   (81%)                  
 
     Example 61  
      The NOV61 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 61A.  
               TABLE 61A                       NOV61 Sequence Analysis                                                NOV61a, CG96384-01   SEQ ID NO: 1191   789 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAA at 787                       ATG CCTTGGGTATGCCGCCCCACTGGCTGGACAAAGCGGCGCGTGGATGTGCCTGTGGGGCCTTGCCC           TGGGCATCGCTGCTGCTGCCAGCGCCCTTCACCCATGCTTCAGCATGGTGCCCATACGCACTTCCTGC       AGGAGTCTGCTGGATACCTGCAGCTGGAGCACAGGAGAGATTTCAGCTCTTCTGGGAGTAGGAAGCTC       TCCTTTGACACTCGTTCCTTAGTGTGCTTTCTGGAAGACCATGGGTTTGCTACTCAGCAAGCAGAAAT       CATTGTGTCTGCATTGGTCCAGGTACTGGAGGCCAACGTGGACATCGTCTACAAAGATATGGCCACCA       AGATGAAGCAGGAGATCGCTCTTCAGCAAATAATGTCTCAGACTGTGAATGTGAAAAACGATATGATT       ACTTTGGAGAAGAGTGAATTTTCAGCCCTCAGAGCAGATCGTGAGAAAATAAAACTCAAACTACATCA       GTTAAAACAAGTAATGGATGAAGTGATTAAAGTCCGAACAGATACTAAATTAGACTTCAACCTAGAAA       AGAGCAGAGTAAAAGAATTGTATTCGTTGAATGAAAGGAAGCTGCTGGAATTGAGAACAGAAATAGTG       ACATTGCATGCCCAGCAAGATTGGGCCGTCACCCAGAGAGATAGGAAGATAGAAACTGAGGATGCTGG       CCCCAAAACCATGCTTGAGTCATACAAGCTTGATAATATTAAATATTTAGCAGGGTCTATATTTACGT       GCCTAACAGTAGCTCTGGGATTTTATCACCTGTGGATC TAA                                       NOV61a, CG96384-01                   Protein Sequence   SEQ ID NO: 1192   262 aa   MW at 30251.7kD                     MPWVCRPTGWTKRRVDVPVGPCPGHRCCCQRPSPMLQHGAHTHFLQESAGYLQLEHRRDFSSSGSRKL           SFDTRSLVCFLEDHGFATQQAEIIVSALVQVLEANVDIVYKDMATKMKQEIALQQIMSQTVNVKNDMI       TLEKSEFSALRAEREKIKLKLHQLKQVMDEVIKVRTDTKLDFNLEKSRVKELYSLNERKLLELRTEIV       TLHAQQDWAVTQRDRKIETEDAGPKTMLESYKLDNIKYLAGSIFTCLTVALGFYHLWI                                     NOV61b, 277580745   SEQ ID NO: 1193   1808 bp           DNA Sequence   ORF Start: at 2   ORF Stop: end of sequence                     CACCGGATCCACCATGCCTTGGGTATGCCGCCCCACTGGCTGGACAAAGCGGCGCGTGGATGTGCCTG           TGGGGCCTTGCCCTGGGCATCGCTGCTGCTGCCAGCGCCCTTCACCCATGCTTCAGCATGGTGCCTAT       ACTCACTTCCTGCAGGAGTCTGCTGGATACCTGCAGCTGGAGCACAGGAGAGATTTCAGCTCTTCTGG       GAGTAGGAAGCTCTCCTTTGACACTCGTTCCTTAGTGTGCTTTCTGGAAGACCATGGGTTTGCTACTC       AGCAAGCAGAAATCATTGTGTCTGCATTGGTCCAGGTACTGGAGGCCAACGTGGACATCGTCTACAAA       GATATGGCCACCAAGATGAAGCAGGAGATCGCTCTTCAGCAAATAATGTCTCAGACTGTGAATGTGAA       AAACGATATGATTACTTTGGAGAAGAGTGAATTTTCAGCCCTCAGAGCAGAACGTGAGAAAATAAAAC       TCAAACTACATCAGTTAAAACAAGTAATGGATGAAGTGATTAAAGTCCGAACAGATACTAAATTAGAC       TTCAACCTAGAAAAGAGCAGAGTAAAAGAATTGTATTCGTTGAATGAAAGGAAGCTGCTGGAATTGAG       AACAGAAATAGTGACATTGCATGCCCAGCAAGATTGGGCCGTCACCCAGAGAGATAGGAAGATAGAAA       CTGAGGATGCTGGCCCCAAAACCATGCTTGAGTCATACAAGCTTGATAATATTAAATATTTAGCAGGG       TCTATATTTACGTGCCTAACAGTAGCTCTGGGATTTTATCACCTGTGGATCCTCGAGGGC                                         NOV61b, 277580745                       Protein Sequence   SEQ ID NO: 1194   269 aa   MW at 30923.4kD                     TGSTMPWVCRPTGWTKRRVDVPVGPCPGHRCCCQRPSPMLQHGAYTHFLQESAGYLQLEHRRDFSSSG           SRKLSFDTRSLVCFLEDHGFATQQAEIIVSALVQVLEANVDIVYKDMATKMKQEIALQQIMSQTVNVK       NDMITLEKSEFSALRAEREKIKLKLHQLKQVMDEVIKVRTDTKLDFNLEKSRVKELYSLNERKLLELR       TEIVTLHAQQDWAVTQRDRKIETEDAGPKTMLESYKLDNIKYLAGSIFTCLTVALGFYHLWILEG                                     NOV61c, CG96384-02   SEQ ID NO: 1195   789 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAA at 787                       ATG CCTTGGGTATGCCGCCCCACTGGCTGGACAAAGCGGCGCGTGGATGTGCCTGTGGGGCCTTGCCC           TGGGCATCGCTGCTGCTGCCAGCGCCCTTCACCCATGCTTCAGCATGGTGCCCATACGCACTTCCTGC       AGGAGTCTGCTGGATACCTGCAGCTGGAGCACAGGAGAGATTTCAGCTCTTCTGGGAGTAGGAAGCTC       TCCTTTGACACTCGTTCCTTAGTGTGCTTTCTGGAAGACCATGGGTTTGCTACTCAGCAAGCAGAAAT       CATTGTGTCTGCATTGGTCCAGGTACTGGAGGCCAACGTGGACATCGTCTACAAAGATATGGCCACCA       AGATGAAGCAGGAGATCGCTCTTCAGCAAATAATGTCTCAGACTGTGAATGTGAAAAACGATATGATT       ACTTTGGAGAAGAGTGAATTTTCAGCCCTCAGAGCAGAACGTGAGAAAATAAAACTCAAACTACATCA       GTTAAAACAAGTAATGGATGAAGTGATTAAAGTCCGAACAGATACTAAATTAGACTTCAACCTAGAAA       AGAGCAGAGTAAAAGAATTGTATTCGTTGAATGAAAGGAAGCTGCTGGAATTGAGAACAGAAATAGTG       ACATTGCATGCCCAGCAAGATTGGGCCGTCACCCAGAGAGATAGGAAGATAGAAACTGAGGATGCTGG       CCCCAAAACCATGCTTGAGTCATACAAGCTTGATAATATTAAATATTTAGCAGGGTCTATATTTACGT       GCCTAACAGTAGCTCTGGGATTTTATCACCTGTGGATC TAA                                           NOV61c, CG96384-02                       Protein Sequence   SEQ ID NO: 1196   1262 aa   MW at 30251.7kD                     MPWVCRPTGWTKRRVDVPVGPCPGHRCCCQRPSPMLQHGAHTHFLQESAGYLQLEHRRDFSSSGSRKL           SFDTRSLVCFLEDHGFATQQAEIIVSALVQVLEANVDIVYKDMATKMKQEIALQQIMSQTVNVKNDMI       TLEKSEFSALRAEREKIKLKLHQLKQVMDEVIKVRTDTKLDFNLEKSRVKELYSLNERKLLELRTEIV       TLHAQQDWAVTQRDRKIETEDAGPKTMLESYKLDNIKYLAGSIFTCLTVALGFYHLWI                                     NOV61d, CG96384-03   SEQ ID NO: 1197   1285 bp           DNA Sequence   ORF Start: at 31   ORF Stop: at 280                       GGATCCACCATGCCTTGGGTATGCCGCCCC ACTGGCTGGACAAAGCGGCGCGTGGATGTGCCTGTGGG           GCCTTGCCCTGGGCATCGCTGCTGCTGCCAGCGCCCTTCACCCATGCTTCAGCATGGTGCCTATACTC       ACTTCCTGCAGGAGTCTGCTGGATACCTGCAGCTGGAGCACAGGAGAGATTTCAGCTCTTCTGGGAGT       AGGAAGCTCTCCTTTGACACTCGTTCCTTAGTGTGCTTTCTGGAAGACCATGGGTTTGCTACTCAGCA       AGCAGAACTC GAG                                           NOV61d, CG96384-03                       Protein Sequence   SEQ ID NO: 1198   183 aa   MW at 9410.5kD                     TGWTKRRVDVPVGPCPGHRCCCQRPSPMLQHGAYTHFLQESAGYLQLEHRPDFSSSGSRKLSFDTRSL           VCFLEDHGFATQQAE                                     NOV61e, CG96384-04   SEQ ID NO: 1199   1801 bp           DNA Sequence   ORF Start: at 31   ORF Stop: at 772                       GGATCCACCATGCCTTGGGTATGCCGCCCC ACTGGCTGGACAAAGCGGCGCGTGGATGTGCCTGTGGG           GCCTTGCCCTGGGCATCGCTGCTGCTGCCAGCGCCCTTCACCCATGCTTCAGCATGGTGCCTATACTC       ACTTCCTGCAGGAGTCTGCTGGATACCTGCAGCTGGAGCACAGGAGAGATTTCAGCTCTTCTGGGAGT       AGGAAGCTCTCCTTTGACACTCGTTCCTTAGTGTGCTTTCTGGAAGACCATGGGTTTGCTACTCAGCA       AGCAGAAATCATTGTGTCTGCATTGGTCCAGGTACTGGAGGCCAACGTGGACATCGTCTACAAAGATA       TGGCCACCAAGATGAAGCAGGAGATCGCTCTTCAGCAAATAATGTCTCAGACTGTGAATGTGAAAAAC       GATATGATTACTTTGGAGAAGAGTGAATTTTCAGCCCTCAGAGCAGAACGTGAGAAAATAAAACTCAA       ACTACATCAGTTAAACAAGTAATGGATGAAGTGATTTAAAGTCCGAACAGATACTAAATTAGACTTCA       ACCTAGAAAAGAGCAGAGTAAAAGAATTGTATTCGTTGAATGAAAGGAAGCTGCTGGAATTGAGAACA       GAAATAGTGACATTGCATGCCCAGCAAGATTGGGCCGTCACCCAGAGAGATAGGAAGATAGAAACTGA       GGATGCTGGCCCCAAAACCATGCTTGAGTCATACAAGCTTGATAATATTAAATATTTAGCAGGGTCTA       TATTTACGTGCCTAACAGTAGCTCTG GGATTTTATCACCTGTGGATCCTCGAG                                           NOV61e, CG96384-04                       Protein Sequence   SEQ ID NO: 1200   247 aa   MW at 28377.4kD                     TGWTKRRVDVPVGPCPGHRCCCQRPSPMLQHGAYTHFLQESAGYLQLEHRRDFSSSGSRKLSFDTRSL           VCFLEDHGFATQQAEIIVSALVQVLEANVDIVYKDMATKMKQEIALQQIMSQTVNVKNDMITLEKSEF       SALRAEREKIKLKLHQLKQVMDEVIKVRTDTKLDFNLEKSRVKELYSLNERKLLELRTEIVTLHAQQD       WAVTQRDRKIETEDAGPKTMLESYKLDNIKYLAGSIFTCLTVA                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 61B.  
               TABLE 61B                       Comparison of the NOV61 protein sequences.                                            NOV61a   ----MPWVCRPTGWTKRRVDVPVGPCPGHRCCCQRPSPMLQHGAHTHFLQESAGYLQLEH           NOV61b   TGSTMPWVCRPTGWTKRRVDVPVGPCPGHRCCCQRPSPMLQHGAYTHFLQESAGYLQLEH       NOV61c   ----MPWVCRPTGWTKRRVDVPVGPCPGHRCCCQRPSPMLQHGAHTHFLQESAGYLQLEH       NOV61d   -----------TGWTKRRVDVPVGPCPGHRCCCQRPSPMLQHGAYTHFLQESAGYLQLEH       NOV61e   -----------TGWTKRRVDVPVGPCPGHRCCCQRPSPMLQHGAYTHFLQESAGYLQLEH               N0V61a   RRDFSSSGSRKLSFDTRSLVCFLEDHGFATQQAEIIVSALVQVLEANVDIVYKDMATKMK       N0V61b   RRDFSSSGSRKLSFDTRSLVCFLEDHGFATQQAEIIVSALVQVLEANVDIVYKDMATKMK       N0V61c   RRDFSSSGSRKLSFDTRSLVCFLEDHGFATQQAEIIVSALVQVLEANVDIVYKDMATKMK       NOV61d   RRDFSSSGSRKLSFDTRSLVCFLEDHGFATQQAE--------------------------       N0V61e   RRDFSSSGSRKLSFDTRSLVCFLEDHGFATQQAEIIVSALVQVLEANVDIVYKDMATKMK               NOV61a   QEIALQQIMSQTVNVKNDMITLEKSEFSALRAEREKIKLKLHQLKQVMDEVIKVRTDTKL       NOV61b   QEIALQQIMSQTVNVKNDMITLEKSEFSALRAEREKIKLKLHQLKQVMDEVIKVRTDTKL       NOV61c   QEIALQQIMSQTVNVKNDMITLEKSEFSALRAEREKIKLKLHQLKQVMDEVIKVRTDTKL       NOV61d   ------------------------------------------------------------       NOV61e   QEIALQQIMSQTVNVKNDMITLEKSEFSALRAEREKIKLKLHQLKQVMDEVIKVRTDTKL               NOV61a   DFNLEKSRVKELYSLNERKLLELRTEIVTLHAQQDWAVTQRDRKIETEDAGPKTMLESYK       NOV61b   DFNLEKSRVKELYSLNERKLLELRTEIVTLHAQQDWAVTQRDRKIETEDAGPKTMLESYK       NOV61c   DFNLEKSRVKELYSLNERKLLELRTEIVTLHAQQDWAVTQRDRKIETEDAGPKTMLESYK       NOV61d   ------------------------------------------------------------       NOV61e   DFNLEKSRVKELYSLNERKLLELRTEIVTLHAQQDWAVTQRDRKIETEDAGPKTMLESYK               NOV61a   LDNIKYLAGSIFTCLTVALGFYHLWI---       NOV61b   LDNIKYLAGSIFTCLTVALGFYHLWILEG       NOV61c   LDNIKYLAGSTFTCLTVALGFYHLWI---       NOV61d   -----------------------------       NOV61e   LDNIKYLAGSIFTCLTVA-----------               NOV61a   (SEQ IDNO: 1192)       NOV61b   (SEQ IDNO: 1194)       NOV61c   (SEQ IDNO: 1196)       NOV61d   (SEQ IDNO: 1198)       NOV61e   (SEQ IDNO: 1200)                  
 
      Further analysis of the NOV61a protein yielded the following properties shown in Table 61C.  
               TABLE 61C                       Protein Sequence Properties NOV61a                                        SignalP analysis:   No Known Signal Sequence Predicted       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 6; pos. chg 1; neg. chg 0           H-region:   length 5; peak value −14.81           PSG score:   −19.21                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): −11.24           possible cleavage site: between 29 and 30                 &gt;&gt;&gt; Seems to have no N-terminal signal peptide                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 1           Tentative number of TMS(s) for the threshold 0.5: 2           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 91-107               −2.13                             PERIPHERAL   Likelihood = 11.30 (at 68)                         ALOM score: −2.13 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 98           Charge difference: 1.5 C(−1.0)-N(−2.5)           C &gt; N: C-terminal side will be inside                 &gt;&gt;&gt; membrane topology: type 1b (cytoplasmic tail 91 to 262)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   3   Hyd Moment(75):   7.07           Hyd Moment(95):   9.21   G content:   1           D/E content:   1   S/T content:   2                         Score: −1.63       Gavel:   prediction of cleavage sites for mitochondrial preseq           R-10 motif at 68 RRD FS                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: none           bipartite: none           content of basic residues: 14.1%           NLS Score: −0.47       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals: none       SKL: peroxisomal targeting signal in the C-terminus: none       PTS2: 2nd peroxisomal targeting signal: found       KIKLKLHQL at 152       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: found                         LL at 196                 checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 76.7       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions       138 E   0.87       139 K   0.87       140 S   0.87       141 E   0.87       142 F   0.87       143 S   0.87       144 A   0.87       145 L   0.87       146 R   0.87       147 A   0.87       148 E   0.87       149 R   0.87       150 E   0.87       151 K   0.87       152 I   0.87       153 K   0.87       154 L   0.87       155 K   0.87       156 L   0.87       157 H   0.87       158 Q   0.87       159 L   0.87       160 K   0.87       161 Q   0.87       162 V   0.87       163 M   0.87       164 D   0.87       165 E   0.87       166 V   0.86       167 I   0.79       168 K   0.79       169 V   0.59       170 R   0.59       171 T   0.59       172 D   0.59           total: 35 residues                 Final Results (k = 9/23):                         34.8%: nuclear           21.7%: mitochondrial           21.7%: cytoplasmic            8.7%: vesicles of secretory system            4.3%: vacuolar            4.3%: peroxisomal            4.3%: endoplasmic reticulum                 &gt;&gt; prediction for CG96384-01 is nuc (k = 23)                  
 
      A search of the NOV61a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 61D.  
               TABLE 61D                          Geneseq Results for NOV61a                                         NOV61a   Identities/               Protein/Organism/Length   Residues/   Similarities for       Geneseq   [Patent #,   Match   the Matched   Expect       Identifier   Date]   Residues   Region   Value                                             AAM40693   Human polypeptide SEQ ID NO 5624 -   45 . . . 262   185/220   (84%)   2e−95             Homo sapiens , 246 aa.   27 . . . 246   197/220   (89%)           [WO200153312-A1, 26-JUL-2001]       AAM38907   Human polypeptide SEQ ID NO 2052 -   104 . . . 262    138/160   (86%)   3e−70             Homo sapiens , 160 aa.    1 . . . 160   145/160   (90%)           [WO200153312-A1, 26-JUL-2001]       AAG73708   Human colon cancer antigen protein   142 . . . 262    110/122   (90%)   9e−54           SEQ ID NO: 4472 -  Homo sapiens , 129    8 . . . 129   114/122   (93%)           aa. [WO200122920-A2, 05-APR-2001]       ABU53059   Human testes-derived protein from   59 . . . 261   96/204   (47%)   3e−48           DKFZphtes3_19f19 -  Homo sapiens ,   50 . . . 253   138/204   (67%)           254 aa. [WO200112659-A2, 22-FEB-2001]       ABB89935   Human polypeptide SEQ ID NO 2311 -   59 . . . 261   96/204   (47%)   3e−48             Homo sapiens , 245 aa.   41 . . . 244   138/204   (67%)           [WO200190304-A2, 29-NOV-2001]                  
 
      In a BLAST search of public sequence databases, the NOV61a protein was found to have homology to the proteins shown in the BLASTP data in Table 61E.  
               TABLE 61E                          Public BLASTP Results for NOV61a                                         NOV61a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value                                             Q96JS7   Similar to RIKEN cDNA 6230416A05   45 . . . 262   186/220   (84%)   1e−96           gene -  Homo sapiens  (Human), 321   102 . . . 321    198/220   (89%)           aa (fragment).       Q96AQ8   Similar to RIKEN cDNA 6230416A05   45 . . . 262   185/220   (84%)   6e−95           gene -  Homo sapiens  (Human), 359   140 . . . 359    197/220   (89%)           aa.       Q9NUI2   DJ500L14.1 (Novel protein) -  Homo     45 . . . 262   185/220   (84%)   6e−95             sapiens  (Human), 220 aa (fragment).    1 . . . 220   197/220   (89%)       Q9CXD6   6230416A05Rik protein -  Mus     45 . . . 262   163/220   (74%)   3e−83             musculus  (Mouse), 340 aa.   121 . . . 340    188/220   (85%)       Q9GZT6   MDS011 (MDS025) (Hypothetical   59 . . . 261   96/204   (47%)   9e−48           protein) -  Homo sapiens  (Human),   50 . . . 253   138/204   (67%)           254 aa.                  
 
      PFam analysis predicts that the NOV61a protein contains the domains shown in the Table 61F.  
               TABLE 61F                       Domain Analysis of NOV61a                                                        Pfam   NOV61a   Identities/   Expect           Domain   Match Region   Similarities for   Value                   the Matched Region                      
 
     Example 62  
      The NOV62 clone was analyzed, and the nucleotide and encoded polypeptide sequences are shown in Table 62A.  
               TABLE 62A                       NOV62 Sequence Analysis                                                NOV62a, CG98011-01   SEQ ID NO: 1201   12631 bp           DNA Sequence   ORF Start: ATG at 1   ORF Stop: TAG at 2629                       ATG ATTTACATACAAGTAATTTTTCAAGTAATGACCATTGAAAAAATGTTTTCTTTTTATTTTTTAGA           TTATTTCTCTTTATTCAGAAGCATACAGTTGTTTGCTGATTGCAAGAAGATGTTTCTGTGGCTGTTTC       TGATTTTGTCAGCCCTGATTTCTTCGACAAATGCAGATTCTGACATATCGGTGGAAATTTGCAATGTG       TGTTCCTGCGTGTCAGTTGAGAATGTGCTCTATGTCAACTGTGAGAAGGTTTCAGTCTACAGACCAAA       CAGCTAGAAACCACCTTGGTCTAATTTTTATCACCTCAATTTCCAAAATAATTTTTTAAATATTCTGT       ATCCAAATACATTCTTGAATTTTTCACATGCAGTCTCCCTGCATCTGGGGAATAATAAACTGCAGAAC       ATTGAGGGAGGAGCCTTTCTTGGGCTCAGTGCATTAAAGCAGTTGCACTTGAACAACAATGAATTAAA       GATTCTCCGAGCTGACACTTTCCTTGGCATAGAGAACTTGGAGTATCTCCAGGCTGACTACAATTTAA       TCAAGTATATTGAACTGAGGAGCCTTCAATAAGCTCCACAAACTGAAGTTCTCATTCTTTTTGACAAT       CTGATTTCATTCCTTCCTGATAATATTTTCCGATTCGCATCTTTGACCCATCTGGATATACGAGGGAA       CAGAATCCAGAAGCTCCCTTATATCGGGGTTCTGGAACACATTGGCCGTGTCGTTGAATTGCAACTGG       AACATTTACATAGGAGAAGCTATCTGTGAAACTCCCAGTGACTTATATGGAAGGCTTTTAAAAGAAAC       AGCTGGAAAATGGCTACACCACTCCCAATGGTCACACTACCCAAACATCTTTACACAGATTAGTAACT       AAACCACCAAAAACAACAAATCCTTCCAAGATCTCTGGAATCGTTGCAGGCAAAGCCCTCTCCAACCG       CAATCTCAGTCAGATTGTGTCTTACCAAACAAGGGTGCCTCCTCTAACACCTTGCCCGGCACCTTGCT       TCTGCAAAACACACCCTTCAGATTTGGGACTAAGTGTGAACTGCCAAGAGAAAAATATACAGTCTATG       TCTGAACTGATACCGAAACCTTTAAATGCGAAGAAGCTGCACGTCAATGGCAATAGCATCAAGGATGT       GGACGTATCAGACTTCACTGACTTTGAAGGACTGGATTTGCTTCATCTAGGCAGCAATCAAATTACAG       TGATTAAGGGAGACGTATTTCACAATCTCACTAATTTACGCAGGCTATATCTCAATGGCAATCAAATT       GAGAGACTCTATCCTGAAATATTTTCAGGTCTTCATAACCTGCAGTATCTGTATTTGGAATACAATTT       GATTAAGGAAATCTCAGCAGGCACCTTTGACTCCATGCCAAATTTGCAGTTACTGTACTTAAACAATA       ATCTCCTAAAGAGCCTGCCTGTTTACATCTTTTCCGGAGCACCCTTAGCTAGACTGAACCTGAGGAAC       AACAAATTCATGTACCTGCCTGTCAGTGGGGTCCTTGATCAGTTGCAATCTCTTACACAGATTGACTT       GGAGGGCAACCCATGGGACTGTACTTGTGACTTGGTGGCATTAAAGCTGTGGGTGGAGAAGTTGAGCG       ACGGGATTGTTGTGAAAGAACTGAAATGTGAGACGCCTGTTCAGTTTGCCAACATTGAACTGAAGTCC       CTCAAAAATGAAATCTTATGTCCCAAACTTTTAAATAAGCCGTCTGCACCATTCACAAGCCCTGCACC       TGCCATTACATTCACCACTCCTTTGGGTCCCATTCGAAGTCCTCCTGGTGGGCCAGTGCCTCTGTCTA       TTTTAATCTTAAGTATCTTAGTGGTCCTCATTTTAACGGTGTTTGTTGCTTTTTGCCTTCTTGTTTTT       GTCCTGCGACGCAACAAGAAACCCACAGTGAAGCACGAAGGCCTGGGGAATCCTGACTGTGGCTCCAT       GCAGCTGCAGCTAAGGAAGCATGACCACAAAACCAATAAAAAAGATGGACTGAGCACAGAAGCTTTCA       TTCCACAAACTATAGAACAGATGAGCAAGAGCCACACTTGTGGCTTGAAAGAGTCAGAAACTGGGTTC       ATGTTTTCAGATCCTCCAGGACAGAAAGTTGTTATGAGAAATGTGGCCGACAAGGAGAAAGATTTATT       ACATGTAGATACCAGGAAGAGACTGAGCACAATTGATGAGCTGGATGAATTATTCCCTAGCAGGGATT       CCAATGTGTTTATTCAGAATTTTCTTGAAAGCAAAAAGGAGTATAATAGCATAGGTGTCAGTGGCTTT       GAGATCCGCTATCCAGAAAAACAACCAGACAAAAAAAGTAAGAAGTCACTGATAGGTGGCAACCACAG       TAAAATTGTTGTGGAACAAAGGAAGAGTGAGTATTTTGAACTGAAGGCGAAACTGCAGAGTTCCCCTG       ACTACCTACAGGTCCTTGAGGAGCAAACAGCTTTGAACAAGATC TAG                                           NOV62a, CG98011-01                       Protein Sequence   SEQ ID NO: 1202   876 aa   MW at 99167.6kD                     MIYIQVIFQVMTIEKMFSFYFLDYFSLFRSIQLFADCKKMFLWLFLILSALISSTNADSDISVEICNV           CSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQN       IEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDN       LISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPY       NIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVT       KPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSM       SELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRPLYLNGNQI       ERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLAELNLRN       NKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKS       LKNEILCPKLLNKPSAPFTSPAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVF       VLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTAKKDGLSTEAFIPQTIEQMSKSHTCGLKESETGF       MFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGF       EIRYPEKQPDKKSKKSLIGGNHSKIVVEQRKSEYFELKAXLQSSPDYLQVLEEQTALNKI                                     NOV62b, 192586956   SEQ ID NO: 1203   1800 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GGATCCGATTCTGACATATCGGTGGAAATTTGCAATGTGTGTTCCTGCGTGTCAGTTGAGAATGTGCT           CTATGTCAACTGTGAGAAGGTTTCAGTCTACAGACCAAATCAGCTGAAACCACCTTGGTCTAATTTTT       ATCACCTCAATTTCCAAAATAATTTTTTAAATATTCTGTATCCAAATACATTCTTGAATTTTTCACAT       GCAGTCTCCCTGCATCTGGGGAATAATAAACTGCAGAACATTGAGGGAGGAGCCTTTCTTGGGCTCAG       TACATTAAAGCAGTTGCACTTGAACAACAATGAATTAAAGATTCTCCGAGCTGACACTTTCCTTGGCA       TAGAGAACTTGGAGTATCTCCAGGCTGACTACAATTTAATCAAGTATATTGAACGAGGAGCCTTCAAT       AAGCTCCACAAACTGAAAGTTCTCATTCTTAATGACAATCTGATTTCATTCCTTCCTGATAATATTTT       CCGATTCGCATCTTTGACCCATCTGGATATACGAGGGAACAGAATCCAGAAGCTCCCTTATATCGGGG       TTCTGGAACACATTGGTCGTGTCGTTGAATTGCAACTGGAAGATAACCCTTGGAACTGTAGCTGTGAT       TTATTGCCCTTAAAAGCTTGGCTGGAGAACATGCCATATAACATTTACATAGGAGAAGCTATCTGTGA       AACTCCCAGTGACTTATATGGAAGGCTTTTAAAAGAAACCAACAAACAAGAGCTATGTCCCATGGGCA       CCGGCAGTGATTTTGACGTGCGCATCCTGCCTCCATCTCAGCTGGAAAATGGCTACACCACTCCCAAT       GGTCACACTACCCAAACATCTTTACACAGATTAGTAACTAAACCACCAAAAACAACAAATCCTTCCAA       GATCTCTGGAATCGTTGCAGGTAAAGCCCTCTCCAACCGCAATCTCAGTCAGATTGTGTCTTACCAAA       CAAGGGTGCCTCCTCTAACACCTTGCCCGGCACCTTGCTTCTGCAAAACACACCCTTCAGATTTGGGA       CTAAGTGTGAACTGCCAAGAGAAAAATATACAGTCTATGTCTGAACTGATACCGAAACCTTTAAATGC       GAAGAAGCTGCACGTCAATGGCAATAGCATCAAGGATGTGGACGTATCAGACTTCACTGACTTTGAAG       GACTGGATTTGCTTCATTTAGGCAGCAATCAAATTACAGTGATTAAGGGAGACGTATTTCACAATCTC       ACTAATTTACGCAGGCTATATCTCAATGGCAATCAAATTGAGAGACTCTATCCTGAAATATTTTCAGG       TCTTCATAACCTGCAGTATCTGTATTTGGAATACAATTTGATTAAGGAAATCTCAGCAGGCACCTTTG       ACTCCATGCCAAATTTGCAGTTACTGTACTTAAGCAATAATCTCCTAAAGAGCCTGCCTGTTTACATC       TTTTCCGGAGCACCCTTAGCTAGACTGAACCTGAGGAACAACATATTCATGTACCTGCCTGTCAGTGG       GGTCCTTGATCAGTTGCAATCTCTTACACAGATTGACTTGGAGGGCAGCCCATGGGACTATACTTGTG       ACTTGGTGGCATTAAAGCTGTGGGTGGAGAAGTTGAGCGACGGGATTGTTGTGAAAGAACTGAAATGT       TTTTCCGGAGCACCCTTAGCTAGACTGAACCTGAGGAACAACAAATTCATGTACCTGCCTGTCAGTGG       TTTAAATAAGCCGTCTGCACCATTCACAAGCCCTGCACCTGCCATTACATTCACCACTCCTTTGGGTC       CCATTCGAAGTCCTCCTGGTGGGCCACTCGAG                                         NOV62b, 192586956                       Protein Sequence   SEQ ID NO: 1204   1600 aa   MW at 67403.8kD                     GSDSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSH           AVSLHLGNNKLQNIEGGAFLGLSTLKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFN       KLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCD       LLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPN       GHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLG       LSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNL       TNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLSNNLLKSLPVYI       FSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGSPWDYTCDLVALKLWVEKLSDGIVVKELKC       IETPVQFTNIELKSLKEILCPKLLNKPSAPFTSPAPAITFTTPLGPIRSPPGGPLE                                     NOV62c, 191999007   SEQ ID NO: 1205   1800 bp           DNA Sequence   ORF Start: at 1   ORF Stop: end of sequence                     GGATCCGATTCTGACATATCGGTGGAAATTTGCAATGTGTGTTCCTGCGTGTCAGTTGAGAATGTGCT           CTATGTCAACTGTGAGAAGGTTTCAGTCTACAGACCAAATCAGCTGAAACCACCTTGGTCTAATTTTT       ATCACCTCAATTTCCAATAATTTTTTAATTTTATTCTGTATCCAAATACATTCTTGAATTTTTCACAT       GCAGTCTCCCTGCATCTGGGGAATAATAAACTGCAGAACATTGAGGGAGGAGCCTTTCTTGGGCTCAG       TGCATTAAAGCAGTTGCACTTGAACAACAATGAATTAAAGATTCTCCGAGCTGACACTTTCCCTGGCA       TAGAGAACTTGGAGTATCTCCAGGCTGACTACAATTTAATCAAGTATATTGAACGAGGAGCCTTCAAT       AAGCTCCACAAACTGAAAGTTCTCATTCTTAATGACAATCTGATTTCATTCCTTCCTGATAATATTTT       CCGATTCGCATCTTTGACCCATCTGGATATACGAGGGAACAGAATCCAGAAGCTCCCTTATATCGGGG       TTCTGGAACACATTGGCCGTGTCGTTGAATTGCAACTGGAAGATAACCCTTGGAACTGTAGCTGTGAT       TTATTGCCCTTAAAAGCTTGGCTGGAGAACATGCCATATAACATTTACATAGGAGAAGCTATCTGTGA       AACTCCCAGTGACTTATATGGAAGGCTTTTAAAAGAAACCAACAAACAAGAGCTATGTCCCATGGGCA       CCGGCAGTGATTTTGACGTGCGCATCCTGCCTCCATCTCAGCTGGAAAATGGCTACACCACTCCCAAT       GGTCACACTACCCAAACATCTTTACACAGATTAGTAACTAAACCACCAAAAACAACAAATCCTTCCAA       GATCTCTGGAATCGTTGCAGGCAAAGCCCTCTCCAACCGCAATCTCAGTCAGATTGTGTCTTACCAAA       CAAGGGTGCCTCCTCTAACACCTTGCCCGGCACCTTGCTTCTGCAAAACACACCCTTCAGATTTGGGA       CTAAGTGTGAACTGCCAAGAGAAAAATATACAGTCTATGTCTGAACTGATACCGAAACCTTTAAATGC       GAAGAAGCTGCACGTCAATGGCAATAGCATCAAGGATGTGGACGTATCAGACTTCACTGACTTTGAAG       GACTGGATTTGCTTCATTTAGGCAGCAATCAAATTACAGTGATTAAGGGAGACGTATTTCACAATCTC       ACTAATTTACGCAGGCTATATCTCAATGGCAATCAAATTGAGAGACTCTATCCTGAAATATTTTCAGG       TCTTCATAACCTGCAGTATCTGTATTTGGAATACAATTTGATTAAGGAAATCTCAGCAGGCACCTTTG       ACTCCATGCCAAATTTGCAGTTACTGTACTTAAACAATAATCTCCTAAAGAGCCTGCCTGTTTACATC       TTTTCCGGAGCACCCTTAGCTAGACTGAACCTGAGGAACAACAAATTCATGTACCTGCCTGTCAGTGG       GGTCCTTGATCAGTTGCAATCTCTTACACAGATTGACTTGGAGGGCAACCCATGGGACTGTACTTGTG       ACTTGGTGGCATTAAAGCTGTGGGTGGGGAAGTTGAGCGACGGGATTGTTGTGAAAGAACTGAAATGT       GAGACGCCTGTTCAGTTTGCCAACATTGAACTGAAGTCCCTCAAAAATGAAATCTTATGTCCCAAACT       TTTAAATAAGCCGTCTGCACCATTCACAAGCCCTGCACCTACCATTACATTCACCACTCCTTTGGGTC       CCATTCGAAGTCCTCCTGGTGGGCCACTCGAG                                         NOV62c, 191999007                       Protein Sequence   SEQ ID NO: 1206   600 aa   MW at 67279.7kD                     GSDSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNTLYPNTFLNFSH           AVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFPGIENLEYLQADYNLIKYIERGAFN       KLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCD       LLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPN       GHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLG       LSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNL       TNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYI       FSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVGKLSDGIVVKELKC       ETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPTITFTTPLGPIRSPPGGPLE                                     NOV62d, CG98011-02   SEQ ID NO: 1207   12654 bp           DNA Sequence   ORF Start: ATG at 19   ORF Stop: TAG at 2647                       CCATGTGTTCACT   ATG GTATGATTTACATACAAGTAATTTTTCAAGTAATGACCATTGAAAAAATGTT           TTCTTTTTATTTTTTAGATTATTTCTCTTTATTCAGAAGCATACAGTTGTTTGCTGATTGCAAGAAGA       TGTTTCTGTGGCTGTTTCTGATTTTGTCAGCCCTGATTTCTTCGACAAATGCAGATTCTGACATATCG       GTGGAAATTTGCAATGTGTGTTCCTGCGTGTCAGTTGAGAATGTGCTCTATGTCAACTGTGAGAAGGT       TTCAGTCTACAGACCAAATCAGCTGAAACCACCTTGGTCTAATTTTTATCACCTCAATTTCCAAAATA       ATTTTTTAAATATTCTGTATCCAAATACATTCTTGAATTTTTCACATGCAGTCTCCCTGCATCTGGGG       AATAATAAACTGCAGAACATTGAGGGAGGAGCCTTTCTTGGGCTCAGTGCATTAAAGCAGTTGCACTT       GAACAACAATGAATTAAAGATTCTCCGAGCTGACACTTTCCTTGGCATAGAGAACTTGGAGTATCTCC       AGGCTGACTACAATTTAATCAAGTATATTGAACGAGGAGCCTTCAATAAGCTCCACAAACTGAAAGTT       CTCATTCTTAATGACAATCTGATTTCATTCCTTCCTGATAATATTTTCCGATTCGCATCTTTGACCCA       TCTGGATATACGAGGGAACAGAATCCAGAAGCTCCCTTATATCGGGGTTCTGGAACACATTGGCCGTG       TCGTTGAATTGCAACTGGAAGATAACCCTTGGAACTGTAGCTGTGATTTATTGCCCTTAAAAGCTTGG       CTGGAGAACATGCCATATAACATTTACATAGGAGAAGCTATCTGTGAAACTCCCAGTGACTTATATGG       AAGGCTTTTAAAGAAACCAACAAACAAGAGCTATGATCCCATGGGCACCGGCAGTGATTTTGACGTGC       GCATCCTGCCTCCATCTCAGCTGGAAAATGGCTACACCACTCCCAATGGTCACACTACCCAAACATCT       TTACACAGATTAGTAACTAACCACCAAAAACAACAAATCACTTCCAAGATCTCTGGAATCGTTGCAGG       CAAAGCCCTCTCCAACCGCAATCTCAGTCAGATTGTGTCTTACCAAACAAGGGTGCCTCCTCTAACAC       CTTGCCCGGCACCTTGCTTCTGCAAAACACACCCTTCAGATTTGGGACTAAGTGTGAACTGCCAAGAG       AAAATATACAGTCTATGTCTGAACTGATACCGAAACCTTTAAAATGCGAAGAAGCTGCACGTCAATGG       CAATAGCATCAAGGATGTGGACGTATCAGACTTCACTGACTTTGAAGGACTGGATTTGCTTCATTTAG       GCAGCAATCAAATTACAGTGATTAAGGGAGACGTATTTCACAATCTCACTAATTTACGCAGGCTATAT       CTCAATGGCAATCAAATTGAGAGACTCTATCCTGAAATATTTTCAGGTCTTCATAACCTGCAGTATCT       GTATTTGGAATACAATTTGATTAAGGAAATCTCAGCAGGCACCTTTGACTCCATGCCAAATTTGCAGT       TACTGTACTTAAACAATAATCTCCTAAAGAGCCTGCCTGTTTACATCTTTTCCGGAGCACCCTTAGCT       AGACTGAACCTGAGGAACAACAAATTCATGTACCTGCCTGTCAGTGGGGTCCTTGATCAGTTGCAATC       TCTTACACAGATTGACTTGGAGGGCAACCCATGGGACTGTACTTGTGACTTGGTGGCATTAAAGCTGT       GGGTGGAGAAGTTGAGCGACGGGATTGTTGTGAAAGAACTGAAATGTGAGACGCCTGTTCAGTTTGCC       AACATTGAACTGAAGTCCCTCAAAAATGAAATCTTATGTCCCAAACTTTTAAATAAGCCGTCTGCACC       ATTCACAAGCCCTGCACCTGCCATTACATTCACCACTCCTTTGGGTCCCATTCGAAGTCCTCCTGGTG       GGCCAGTGCCTCTGTCTATTTTAATCTTAAGTATCTTAGTGGTCCTCATTTTAACGGTGTTTGTTGCT       TTTTGCCTTCTTGTTTTTGTCCTGCGACGCAACAAGAAACCCACAGTGAAGCACGAAGGCCTGGGGAA       TCCTGACTGTGGCTCCATGCAGCTGCAGCTAAGGAAGCATGACCACAAAACCAATAAAAAAGATGGAC       TGAGCACAGAAGCTTTCATTCCACAAACTATAGAACAGATGAGCAAGAGCCACACTTGTGGCTTGAAA       GAGTCAGAAACTGGGTTCATGTTTTCAGATCCTCCAGGACAGAAAGTTGTTATGAGAAATGTGGCCGA       CAAGGAGAAAGATTTATTACATGTAGATACCAGGAAGAGACTGAGCACAATTGATGAGCTGGATGAAT       TATTCCCTAGCAGGGATTCCAATGTGTTTATTCAGAATTTTCTTGAAAGCAAAAAGGAGTATAATAGC       ATAGGTGTCAGTGGCTTTGAGATCCGCTATCCAGAAAAACAACCAGACAAAAAAAGTAAGAAGTCACT       GATAGGTGGCAACCACAGTAAAATTGTTGTGGAACAAAGGAAGAGTGAGTATTTTGAACTGAAGGCGA       AACTGCAGAGTTCCCCTGACTACCTACAGGTCCTTGAGGAGCAAACAGCTTTGAACAAGATC TAG   GTC           AT                                           NOV62d, CG9801 -02                       Protein Sequence   SEQ ID NO: 1208   876 aa   MW at 99167.6kD                     MIYIQVIFQVMTIEKMFSFYFLDYFSLFRSIQLFADCKKMFLWLFLILSALISSTNADSDISVEICNV           CSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQN       IEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDN       LISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRWELQLEDNPWNCSCDLLPLKAAWLENMPY       NIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVT       KPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSM       SELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQI       ERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRN       NKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKS       LKNEILCPKLLNKPSAPFTSPAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVF       VLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTCGLKESETGF       MFSDPPGQKVTMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGF       EIRYPEKQPDKKSKKSLIGGNHSKIVVEQRKSEYFELKAXLQSSPDYLQVLEEQTALNKI                                     NOV62e, CG98011-03   SEQ ID NO: 1209   12469 bp           DNA Sequence   ORF Start: at 7   ORF Stop: at 2464                       GGATCC GATTCTGACATATCGGTGGAAATTTGCAATGTGTGTTCCTGCGTGTCAGTTGAGAATGTGCT           CTATGTCAACTGTGAGAAGGTTTCAGTCTACAGGCCAAATCAGCTGAAACCACCTTGGTCTAATTTTT       ATCACCTCAATTTCCAAAATAATTTTTTAAATATTCTGTATCCAAATACATTCTTGAATTTTTCACAT       GCAGTCTCCCTGCATCTGGGGAATAATAAACTGCAGAACATTGAGGGAGGAGCCTTTCTTGGGCTCAG       TGCATTAAAGCAGTTGCACTTGAACAACAATGAATTAAAGATTCTCCGAGCTGACACTTTCCTTGGCA       TAGAGAACTTGGAGTATCTCCAGGCTGACTACAATTTAATCMiGTATATTGAACGAGGAGCCTTCAAT       AAGCTCCACAAACTGAAAGTTCTCATTCTTAATGACAATCTGATTTCATTCCTTCCTGATAATATTTT       CCGATTCGCATCTTTGACCCATCTGGATATACGAGGGAACAGAATCCAGAAGCTCCCTTATATCGGGG       TTCTGGATCACATTGGCCGTGTCGTTGAATTGCAACTGGAAGATAACCCTTGGAACTGTAGCTGTGAT       TTATTGCCCTTAAAAGCTTGGCTGGAGAACATGCCATATAACATTTACATAGGAGAAGCTATCTGTGA       AACTCCCAGTGACCTATATGGAAGGCTTTTAAAAGAAACCAACAAACAAGAGCTATGTCCCATGGGCA       CCGGCAGTGATTTTGACGTGCGCATCCTGCCTCCATCTCAGCTGGAAAATGGCTACACCACTCCCAAT       GGTCACACTACCCAAACATCTTTACACAGATTAGTAACTAAACCACCAAAAACAACAAATCCTTCCAA       GATCTCTGGAATCGTTGCAGGCAAAGCCCTCTCCAACCGCAATCTCAGTCAGATTGTGTCTTACCAAA       CAAGGGTGCCTCCTCTAACACCTTGCCCGGCACCTTGCTTCTGCAAAACACACCCTTCAGATTTGGGA       CTAAGTGTGAACTGCCAAGAGAAAAATATACAGTCTATGTCTGAACTGATACCGAAACCTTTAAATGC       GAAGAAGCTGCACGTCAATGGCAATAGCATCAAGGATGTGGACGTATCAGACTTCACTGACTTTGAAG       GACTGGATTTGCTTCATTTAGGCAGCAATCAAATTACAGTGATTAAGGGAGACGTATTTCACAATCTC       ACTAATTTACGCAGGCTATATCTCAATGGCAATCAAATTGAGAGACTCTATCCTGAAATATTTTCAGG       TCTTCATAACCTGCAGTATCCGTATTTGGAATACAATTTGATTAAGGAAATCTCAGCAGGCACCTTTG       ACTCCATGCCAAATTTGCAGTTACTGTACTTAAACAATAATCTCCTAAAGAGCCTGCCTGTTTACATC       TTTTCCGGAGCACCCTTAGCTAGACTGAACCTGAGGAACAACAAATTCATGTACCTGCCTGTCAGTGG       GGTCCTTGATCAGTTGCAATCTCTTACACAGATTGACTTGGAGGGCAACCCATGGGACTGTACTTGTG       ACTTGGTGGCATTAAAGCTGTGGGTGGAGAAGTTGAGCGACGGGATTGTTGTGAAAGAACTGAAATGT       GAGACGCCTGTTCAGTTTGCCAACATTGAACTGAAGTCCCTCAAAAATGAAATCTTATGTCCCAAACT       TTTAAATAAGCCGTCTGCACCATTCACAAGCCCTGCACCTGCCATTACATTCACCACTCCTTTGGGTC       CCATTCGAAGTCCTCCTGGTGGGCCAGTGCCTCTGTCTATTTTAATCTTAAGTATCTTAGTGGTCCTC       ATTTTAACGGTGTTTGTTGCTTTTTGCCTTCTTGTTTTTGTCCTGCGACGCAACAAGAAACCCACAGT       GAAGCACGAAGGCCTGGGGAATCCTGACTGTGGCTCCATGCAGCTGCAGCTAAGGAAGCATGACCACA       AAACCAATAAAAAAGATGGACTGAGCACAGAAGCTTTCATTCCACAAACTATAGAACAGATGAGCAAG       AGCCACACTTGTGGCTTGAAAGAGTCAGAAACTGGGTTCATGTTTTCAGATCCTCCAGGACAGAAAGT       TGTTATGAGAAATGTGGCCGACAAGGAGAAAGATTTATTACATGTAGATACCAGGAAGAGACTGAGCA       CAATTGATGAGCTGGATGAATTATTCCCTAGCAGGGATTCCAATGTGTTTATTCAGAATTTTCTTGAA       AGCAAAAAGGAGTATAATAGCATAGGTGTCAGTGGCTTTGAGATCCGCTATCCAGAAAAACAACCAGA       CAAAAAAAGTAAGAAGTCACTGATAGGTGGCAACCACAGTAAAATTGTTGTGGAACAAAGGAAGAGTG       AGTATTTTGAACTGAAGGCGAAACTGCAGAGTTCCCCTGACTACCTACAGGTCCTTGAGGAGCAAACA       GCTTTGAACAAGATCCTC GAG                                           NOV62e, CG98011-03                       Protein Sequence   SEQ ID NO: 1210   819 aa   MW at 92291.4kD                     DSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAV           SLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKL       HKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLL       PLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGH       TTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLS       VNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTN       LRRLYLNGNQIERLYPEIFSGLHNLQYPYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFS       GAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDAGIWKELKCET       PVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLIL       TVFVAFCLLVFVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSH       TCGLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESK       KEYNSIGVSGFEIRYPEKQPDKKSKKSLIGGNHSKIVVEQRKSEYFELKAKLQSSPDYLQVLEEQTAL       NKI                                     NOV62f, CG98011-04   SEQ ID NO: 1211   1800 bp           DNA Sequence   ORF Start: at 7   ORF Stop: at 1795                       GGATCC GATTCTGACATATCGGTGGAAATTTGCAATGTGTGTTCCTGCGTGTCAGTTGAGAATGTGCT           CTATGTCAACTGTGAGAAGGTTTCAGTCTACAGACCAAATCAGCTGAAACCACCTTGGTCTAATTTTT       ATCACCTCAATTTCCAAAATAATTTTTTAAATATTCTGTATCCAAATACATTCTTGAATTTTTCACAT       GCAGTCTCCCTGCATCTGGGGAATAATAAACTGCAGAACATTGAGGGAGGAGCCTTTCTTGGGCTCAG       TGCATTAAAGCAGTTGCACTTGAACAACAATGAATTAAAGATTCTCCGAGCTGACACTTTCCCTGGCA       TAGAGAACTTGGAGTATCTCCAGGCTGACTACAATTTAATCAAGTATATTGAACGAGGAGCCTTCAAT       AAGCTCCACAAACTGAAAGTTCTCATTCTTAATGACAATCTGATTTCATTCCTTCCTGATAATATTTT       CCGATTCGCATCTTTGACCCATCTGGATATACGAGGGAACAGAATCCAGAAGCTCCCTTATATCGGGG       TTTCTGGACACATTGGCCGTGTCGTTGAATTGCAACTGGAAGATAACCCTTGGAACTGTAGCTGTGAT       TTATTGCCCTTAAAAGCTTGGCTGGAGAACATGCCATATAACATTTACATAGGAGAAGCTATCTGTGA       AACTCCCAGTGACTTATATGGAAGGCTTTTAAAAGAAACCAACAAACAAGAGCTATGTCCCATGGGCA       CCGGCAGTGATTTTGACGTGCGCATCCTGCCTCCATCTCAGCTGGAAAATGGCTACACCACTCCCAAT       GGTCACACTACCCAAACATCTTTACACAGATTAGTAACTAAACCACCAAAAACAACAAATCCTTCCAA       GATCTCTGGAATCGTTGCAGGCAAAGCCCTCTCCAACCGCAATCTCAGTCAGATTGTGTCTTACCAAA       CAAGGGTGCCTCCTCTAACACCTTGCCCGGCACCTTGCTTCTGCAAAACACACCCTTCAGATTTGGGA       CTAAGTGTGAACTGCCAAGAGAAAAATATACAGTCTATGTCTGAACTGATACCGAAACCTTTAAATGC       GATGAAGCTGCACGTCAATGGCAATAGCATCAAGGATGTGGACGTATCAGACTTCACTGACTTTGAAG       GACTGGATTTGCTTCATTTAGGCAGCAATCAAATTACAGTGATTAAGGGAGACGTATTTCACAATCTC       ACTAATTTACGCAGGCTATATCTCAATGGCAATCAAATTGAGAGACTCTATCCTGAAATATTTTCAGG       TCTTCATAACCTGCAGTATCTGTATTTGGAATACAATTTGATTAAGGAAATCTCAGCAGGCACCTTTG       ACTCCATGCCAAATTTGCAGTTACTGTACTTAAACAATAATCTCCTAAAGAGCCTGCCTGTTTACATC       TTTTCCGGAGCACCCTTAGCTAGACTGAACCTGAGGAACAACAAATTCATGTACCTGCCTGTCAGTGG       GGTCCTTGATCAGTTGCAATCTCTTACACAGATTGACTTGGAGGGCAACCCATGGGACTGTACTTGTG       ACTTGGTGGCATTAAAGCTGTGGGTGGGGAAGTTGAGCGACGGGATTGTTGTGAAAGAACTGAAATGT       GAGACGCCTGTTCAGTTTGCCAACATTGAACTGAAGTCCCTCAAAAATGAAATCTTATGTCCCAAACT       TTTAAATAAGCCGTCTGCACCATTCACAAGCCCTGCACCTACCATTACATTCACCACTCCTTTGGGTC       CCATTCGAAGTCCTCCTGGTGGGCCACTC GAG                                           NOV62f, CG98011-04                       Protein Sequence   SEQ ID NO: 1212   596 aa   MW at 66893.3kD                     DSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAV           SLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFPGIENLEYLQADYNLIKYIERGAFNKL       HKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRWELQLEDANPWNCSCDLL       PLKWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQALENGYTTPNGH       TTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLS       VNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTN       LRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFS       GAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVGKLSDGIVVKELKCET       PVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPTITFTTPLGPIRSPPGGP                  
 
      A ClustalW comparison of the above protein sequences yields the following sequence alignment shown in Table 62B.  
                   TABLE 62B                       Comparison of the NOV62 protein sequences.                                            NOV62a   MIYIQVIFQVMTIEKMFSFYFLDYFSLFRSIQLFADCKKMFLWLFLILSALISSTNADSD           NOV62b   -------------------------------------------------------GSDSD       NOV62c   -------------------------------------------------------GSDSD       NOV62d   MIYIQVIFQVMTTEKMFSFYFLDYFSLFRSIQLFADCKKMFLWLFLILSALISSTNADSD       NOV62e   ---------------------------------------------------------DSD       NOV62f   ---------------------------------------------------------DSD               NOV62a   ISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLN       NOV62b   ISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLN       NOV62c   ISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLN       NOV62d   ISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLN       NOV62e   ISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLN       NOV62f   ISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLN               NOV62a   FSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYN       NOV62b   FSHAVSLHLGNNKLQNIEGGAFLGLSTLKQLHLNNNELKILRADTFLGIENLEYLQADYN       NOV62c   FSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFPGIENLEYLQADYN       NOV62d   FSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYN       NOV62e   FSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYN       NOV62f   FSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFPGIENLEYLQADYN               NOV62a   LIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEH       NOV62b   LIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEH       NOV62c   LIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEH       NOV62d   LIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEH       NOV62e   LIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEH       Nov62f   LIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEH               NOV62a   IGRVVELQLEDNPWNCSCDLLPLKAWLENNPYNIYIGEAICETPSDLYGRLLKETNKQEL       NOV62b   IGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKEThKQEL       NOV62c   IGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQEL       NOV62d   IGRVVELQLEDNPWNCSCDLLPLKAWLENNPYNIYIGEAICETPSDLYGRLLKETNKQEL       NOV62e   IGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQEL       NOV62f   IGRVVELQLEDNPWNCSCDLLPLKAWLENNPYNIYIGEAICETPSDLYGRLLKETNKQEL               NOV62a   CPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKAL       NOV62b   CPMGTGSDFDVRTLPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKAL       NOV62c   CPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKAL       NOV62d   CPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKAL       NOV62e   CPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKAL       NOV62f   CPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKAL               NOV62a   SNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKK       NOV62b   SNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKK       NOV62c   SNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNTQSMSELIPKPLNAKK       NOV62d   SNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKK       NOV62e   SNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKK       NOV62f   SNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKK               NOV62a   LHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLY       NOV62b   LHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLY       NOV62c   LHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLY       NOV62d   LHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLY       NOV62e   LHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLY       NOV62f   LHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLY               NOV62a   PEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARL       NOV62b   PEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLSNNLLKSLPVYIFSGAPLARL       NOV62c   PEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARL       NOV62d   PEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARL       NOV62e   PEIFSGLHNLQYPYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARL       NOV62f   PEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARL               NOV62a   NLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCE       NOV62b   NLRNNKFMYLPVSGVLDQLQSLTQIDLEGSPWDYTCDLVALKLWVEKLSDGIVVKELKCE       NOV62c   NLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVGKLSDGIVVKELKCE       NOV62d   NLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCE       NOV62e   NLRNNKFMYLPVSGVLDQLQSLTQTDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCE       NOV62f   NLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVGKLSDGIVVKELKCE               NOV62a   TPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPATTFTTPLGPIRSPPGGPVPLSILI       NOV62b   TPVQFTNIELKSLKNEILCPKLLNKPSAPFTSPAPATTFTTPLGPIRSPPGGPLE-----       NOV62c   TPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPTITFTTPLGPIRSPPGGPLE-----       NOV62d   TPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITFTTPLGPIRSPPGGPVPLSILI       NOV62e   TPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITFTTPLGPIRSPPGGPVPLSILI       NOV62f   TPVQFANIELKSLKNETLCPKLLNKPSAPFTSPAPTITFTTPLGPIRSPPGGP-------               NOV62a   LSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGL       NOV62b   ------------------------------------------------------------       NOV62c   ------------------------------------------------------------       NOV62d   LSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGL       NOV62e   LSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGL       NOV62f   ------------------------------------------------------------       NOV62a   STEAFIPQTIEQMSKSHTCGLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLS       NOV62b   ------------------------------------------------------------       NOV62c   ------------------------------------------------------------       NOV62d   STEAFIPQTIEQMSKSHTCGLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLS       NOV62e   STEAFIPQTIEQMSKSHTCGLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLS       NOV62f   ------------------------------------------------------------               NOV62a   TIDELDELFPSRDSNVPIQNFLESKKEYNSIGVSGFETRYPEKQPDKKSKKSLIGGNHSK       NOV62b   ------------------------------------------------------------       NOV62c   ------------------------------------------------------------       NOV62d   TIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFETRYPEKQPDKKSKKSLIGGNHSK       NOV62e   TIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQPDKKSKKSLIGGNHSK       NOV62f   ------------------------------------------------------------               NOV62a   IVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNKI       NOV62b   ------------------------------------       NOV62c   ------------------------------------       NOV62d   IVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNKI       NOV62e   IVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNKI       NOV62f   ------------------------------------               NOV62a   (SEQ ID NO: 1202)       NOV62b   (SEQ ID NO: 1204)       NOV62c   (SEQ ID NO: 1206)       NOV62d   (SEQ ID NO: 1208)       NOV62e   (SEQ ID NO: 1210)       NOV62f   (SEQ ID NO: 1212)                  
 
      Further analysis of the NOV62a protein yielded the following properties shown in Table 62C.  
               TABLE 62C                       Protein Sequence Properties NOV62a                                        SignalP analysis:   Cleavage site between residues 58 and 59       PSORT II analysis:                             PSG:   a new signal peptide prediction method                             N-region:   length 0; pos. chg 0; neg. chg 0           H-region:   length 13; peak value 8.16           PSG score:   3.76                     GvH:   von Heijne&#39;s method for signal seq. recognition           GvH score (threshold: −2.1): 2.51           possible cleavage site: between 57 and 58                 &gt;&gt;&gt; Seems to have a cleavable signal peptide (1 to 57)                     ALOM:   Klein et al&#39;s method for TM region allocation           Init position for calculation: 58           Tentative number of TMS(s) for the threshold 0.5: 1           Number of TMS(s) for threshold 0.5: 1                                 INTEGRAL   Likelihood =   Transmembrane 663-679               −16.61                             PERIPHERAL   Likelihood = 2.92 (at 578)                         ALOM score: −16.61 (number of TMSs: 1)       MTOP:   Prediction of membrane topology (Hartmann et al.)           Center position for calculation: 28           Charge difference: 1.0 C(2.0)-N(1.0)           C &gt; N: C-terminal side will be inside                 &gt;&gt;&gt;Caution: Inconsistent mtop result with signal peptide       &gt;&gt;&gt; membrane topology: type 1a (cytoplasmic tail 680 to 876)                     MITDISC:   discrimination of mitochondrial targeting seq                                     R content:   0   Hyd Moment(75):   4.59           Hyd Moment(95):   1.85   G content:   0           D/E content:   2   S/T content:   2                         Score: −7.15       Gavel:   prediction of cleavage sites for mitochondrial preseq           cleavage site motif not found                 NUCDISC: discrimination of nuclear localization signals                         pat4: none           pat7: PDKKSKK (4) at 825           bipartite: none           content of basic residues: 10.4%           NLS Score: −0.13       KDEL:   ER retention motif in the C-terminus: none                 ER Membrane Retention Signals:                         KKXX-like motif in the C-terminus: ALNK                 SKL: peroxisomal targeting signal in the C-terminus: NKI       PTS2: 2nd peroxisomal targeting signal: none       VAC: possible vacuolar targeting motif: none       RNA-binding motif: none       Actinin-type actin-binding motif:                         type 1: none           type 2: none                 NMYR: N-myristoylation pattern: none       Prenylation motif: none       memYQRL: transport motif from cell surface to Golgi: none       Tyrosines in the tail: too long tail       Dileucine motif in the tail: found                         LL at 770                 checking 63 PROSITE DNA binding motifs: none       checking 71 PROSITE ribosomal protein motifs: none       checking 33 PROSITE prokaryotic DNA binding motifs: none                     NNCN:   Reinhardt&#39;s method for Cytoplasmic/Nuclear discrimination           Prediction: cytoplasmic           Reliability: 55.5       COIL:   Lupas&#39;s algorithm to detect coiled-coil regions           total: 0 residues                 Final Results (k = 9/23):                         44.4%: endoplasmic reticulum           22.2%: Golgi           11.1%: plasma membrane           11.1%: vesicles of secretory system           11.1%: extracellular, including cell wall                 &gt;&gt; prediction for CG98011-01 is end (k = 9)                  
 
      A search of the NOV62a protein against the Geneseq database, a proprietary database that contains sequences published in patents and patent publication, yielded several homologous proteins shown in Table 62D.  
               TABLE 62D                          Geneseq Results for NOV62a                                         NOV62a   Identities/                   Residues/   Similarities for       Geneseq   Protein/Organism/Length   Match   the Matched   Expect       Identifier   [Patent #, Date]   Residues   Region   Value               AAE18209   Human MOL2 protein -  Homo sapiens ,   1 . . . 876   876/876 (100%)   0.0           876 aa. [WO200206339-A2, 24-JAN-2002]   1 . . . 876   876/876 (100%)       AAG67510   Amino acid sequence of a human   11 . . . 876    866/866 (100%)   0.0           secreted polypeptide -  Homo sapiens ,   1 . . . 866   866/866 (100%)           866 aa. [WO200166690-A2, 13-SEP-2001]       AAE22221   Human toll like receptor like molecule 4   40 . . . 876    837/837 (100%)   0.0           (TLR-L4) protein -  Homo sapiens , 837   1 . . . 837   837/837 (100%)           aa. [WO200220569-A2, 14-MAR-2002]       ABJ01959   Human IGFALS similar protein SEQ ID   40 . . . 871    832/832 (100%)   0.0           No 660 -  Homo sapiens , 832 aa.   1 . . . 832   832/832 (100%)           [WO200216593-A2, 28-FEB-2002]       ABG36257   Human peptide encoded by genome-   24 . . . 598    575/575 (100%)   0.0           derived single exon probe SEQ ID   1 . . . 575   575/575 (100%)           25922 -  Homo sapiens , 575 aa.           [WO200186003-A2, 15-NOV-2001]                  
 
      In a BLAST search of public sequence databases, the NOV62a protein was found to have homology to the proteins shown in the BLASTP data in Table 62E.  
               TABLE 62E                          Public BLASTP Results for NOV62a                                         NOV62a   Identities/           Protein       Residues/   Similarities for       Accession       Match   the Matched   Expect       Number   Protein/Organism/Length   Residues   Portion   Value               BAC67207   Neuronal transmembrane protein   11 . . . 876   840/866 (96%)   0.0           Slitrk4 -  Mus musculus  (Mouse), 866    1 . . . 866   857/866 (97%)           aa.       Q8IW52   Similar to KIAA0848 protein -  Homo     40 . . . 876    837/837 (100%)   0.0             sapiens  (Human), 837 aa.    1 . . . 837    837/837 (100%)       Q8BWB0   Hypothetical leucine-rich repeat   40 . . . 876   814/837 (97%)   0.0           cysteine-containing subfamily/    1 . . . 837   829/837 (98%)           cysteine-rich flanking region -  Mus               musculus  (Mouse), 837 aa.       Q8C056   Hypothetical leucine-rich repeat   40 . . . 876   813/837 (97%)   0.0           cysteine-containing subfamily/    1 . . . 837   828/837 (98%)           cysteine-rich flanking region -  Mus               musculus  (Mouse), 837 aa.       Q8BYG4   Hypothetical leucine-rich repeat   40 . . . 821   761/782 (97%)   0.0           cysteine-containing subfamily/    1 . . . 782   775/782 (98%)           cysteine-rich flanking region -  Mus               musculus  (Mouse), 782 aa (fragment).                  
 
      PFam analysis predicts that the NOV62a protein contains the domains shown in the Table 62F.  
               TABLE 62F                          Domain Analysis of NOV62a                                             Identities/                       Similarities for           Pfam   NOV62a   the Matched           Domain   Match Region   Region   Expect Value                                                 LRR   218 . . . 239    8/25 (32%)   0.24                   19/25 (76%)           LRRCT   252 . . . 302   18/54 (33%)   9.7e−11                   35/54 (65%)           LRRNT   380 . . . 413   11/36 (31%)   0.0039                   24/36 (67%)           LRR   441 . . . 464    9/25 (36%)   0.31                   16/25 (64%)           LRR   465 . . . 488   13/25 (52%)   0.0072                   23/25 (92%)           LRR   489 . . . 512    6/25 (24%)   0.015                   23/25 (92%)           LRR   513 . . . 536   12/25 (48%)   0.03                   19/25 (76%)           LRRCT   570 . . . 620   14/54 (26%)   8.2e−06                   35/54 (65%)                      
 
     Example B  
     Sequencing Methodology and Identification of NOVX Clones  
      1. GeneCalling™ Technology: This is a proprietary method of performing differential gene expression profiling between two or more samples developed at CuraGen and described by Shimkets, et al., “Gene expression analysis by transcript profiling coupled to a gene database query” Nature Biotechnology 17:198-803 (1999). cDNA was derived from various human samples representing multiple tissue types, normal and diseased states, physiological states, and developmental states from different donors. Samples were obtained as whole tissue, primary cells or tissue cultured primary cells or cell lines. Cells and cell lines may have been treated with biological or chemical agents that regulate gene expression, for example, growth factors, chemokines or steroids. The cDNA thus derived was then digested with up to as many as 120 pairs of restriction enzymes and pairs of linker-adaptors specific for each pair of restriction enzymes were ligated to the appropriate end. The restriction digestion generates a mixture of unique cDNA gene fragments. Limited PCR amplification is performed with primers homologous to the linker adapter sequence where one primer is biotinylated and the other is fluorescently labeled. The doubly labeled material is isolated and the fluorescently labeled single strand is resolved by capillary gel electrophoresis. A computer algorithm compares the electropherograms from an experimental and control group for each of the restriction digestions. This and additional sequence-derived information is used to predict the identity of each differentially expressed gene fragment using a variety of genetic databases. The identity of the gene fragment is confirmed by additional, gene-specific competitive PCR or by isolation and sequencing of the gene fragment.  
      2. SeqCalling™ Technology: cDNA was derived from various human samples representing multiple tissue types, normal and diseased states, physiological states, and developmental states from different donors. Samples were obtained as whole tissue, primary cells or tissue cultured primary cells or cell lines. Cells and cell lines may have been treated with biological or chemical agents that regulate gene expression, for example, growth factors, chemokines or steroids. The cDNA thus derived was then sequenced using CuraGen&#39;s proprietary SeqCalling technology. Sequence traces were evaluated manually and edited for corrections if appropriate. cDNA sequences from all samples were assembled together, sometimes including public human sequences, using bioinformatic programs to produce a consensus sequence for each assembly. Each assembly is included in CuraGen Corporation&#39;s database. Sequences were included as components for assembly when the extent of identity with another component was at least 95% over 50 bp. Each assembly represents a gene or portion thereof and includes information on variants, such as splice forms single nucleotide polymorphisms (SNPs), insertions, deletions and other sequence variations.  
      3. PathCalling™ Technology: The NOVX nucleic acid sequences are derived by laboratory screening of cDNA library by the two-hybrid approach. cDNA fragments covering either the full length of the DNA sequence, or part of the sequence, or both, are sequenced. In silico prediction was based on sequences available in CuraGen Corporation&#39;s proprietary sequence databases or in the public human sequence databases, and provided either the full length DNA sequence, or some portion thereof.  
      The laboratory screening was performed using the methods summarized below:  
      cDNA libraries were derived from various human samples representing multiple tissue types, normal and diseased states, physiological states, and developmental states from different donors. Samples were obtained as whole tissue, primary cells or tissue cultured primary cells or cell lines. Cells and cell lines may have been treated with biological or chemical agents that regulate gene expression, for example, growth factors, chemokines or steroids. The cDNA thus derived was then directionally cloned into the appropriate two-hybrid vector (Gal4-activation domain (Gal4-AD) fusion). Such cDNA libraries as well as commercially available cDNA libraries from Clontech (Palo Alto, Calif.) were then transferred from  E. coli  into a CuraGen Corporation proprietary yeast strain (disclosed in U.S. Pat. Nos. 6,057,101 and 6,083,693, incorporated herein by reference in their entireties).  
      Gal4-binding domain (Gal4-BD) fusions of a CuraGen Corportion proprietary library of human sequences was used to screen multiple Gal4-AD fusion cDNA libraries resulting in the selection of yeast hybrid diploids in each of which the Gal4-AD fusion contains an individual cDNA. Each sample was amplified using the polymerase chain reaction (PCR) using non-specific primers at the cDNA insert boundaries. Such PCR product was sequenced; sequence traces were evaluated manually and edited for corrections if appropriate. cDNA sequences from all samples were assembled together, sometimes including public human sequences, using bioinformatic programs to produce a consensus sequence for each assembly. Each assembly is included in CuraGen Corporation&#39;s database. Sequences were included as components for assembly when the extent of identity with another component was at least 95% over 50 bp. Each assembly represents a gene or portion thereof and includes information on variants, such as splice forms single nucleotide polymorphisms (SNPs), insertions, deletions and other sequence variations.  
      Physical clone: the cDNA fragment derived by the screening procedure, covering the entire open reading frame is, as a recombinant DNA, cloned into pACT2 plasmid (Clontech) used to make the cDNA library. The recombinant plasmid is inserted into the host and selected by the yeast hybrid diploid generated during the screening procedure by the mating of both CuraGen Corporation proprietary yeast strains N106′ and YULH (U.S. Pat. Nos. 6,057,101 and 6,083,693).  
      4. RACE: Techniques based on the polymerase chain reaction such as rapid amplification of cDNA ends (RACE), were used to isolate or complete the predicted sequence of the cDNA of the invention. Usually multiple clones were sequenced from one or more human samples to derive the sequences for fragments. Various human tissue samples from different donors were used for the RACE reaction. The sequences derived from these procedures were included in the SeqCalling Assembly process described in preceding paragraphs.  
      5. Exon Linking: The NOVX target sequences identified in the present invention were subjected to the exon linking process to confirm the sequence. PCR primers were designed by starting at the most upstream sequence available, for the forward primer, and at the most downstream sequence available for the reverse primer. In each case, the sequence was examined, walking inward from the respective termini toward the coding sequence, until a suitable sequence that is either unique or highly selective was encountered, or, in the case of the reverse primer, until the stop codon was reached. Such primers were designed based on in silico predictions for the full length cDNA, part (one or more exons) of the DNA or protein sequence of the target sequence, or by translated homology of the predicted exons to closely related human sequences from other species. These primers were then employed in PCR amplification based on the following pool of human cDNAs: adrenal gland, bone marrow, brain—amygdala, brain—cerebellum, brain—hippocampus, brain—substantia nigra, brain—thalamus, brain—whole, fetal brain, fetal kidney, fetal liver, fetal lung, heart, kidney, lymphoma - Raji, mammary gland, pancreas, pituitary gland, placenta, prostate, salivary gland, skeletal muscle, small intestine, spinal cord, spleen, stomach, testis, thyroid, trachea, uterus. Usually the resulting amplicons were gel purified, cloned and sequenced to high redundancy. The PCR product derived from exon linking was cloned into the pCR2.1 vector from Invitrogen. The resulting bacterial clone has an insert covering the entire open reading frame cloned into the pCR2.1 vector. The resulting sequences from all clones were assembled with themselves, with other fragments in CuraGen Corporation&#39;s database and with public ESTs. Fragments and ESTs were included as components for an assembly when the extent of their identity with another component of the assembly was at least 95% over 50 bp. In addition, sequence traces were evaluated manually and edited for corrections if appropriate. These procedures provide the sequence reported herein.  
      6. Physical Clone: Exons were predicted by homology and the intron/exon boundaries were determined using standard genetic rules. Exons were further selected and refined by means of similarity determination using multiple BLAST (for example, tBlastN, BlastX, and BlastN) searches, and, in some instances, GeneScan and Grail. Expressed sequences from both public and proprietary databases were also added when available to further define and complete the gene sequence. The DNA sequence was then manually corrected for apparent inconsistencies thereby obtaining the sequences encoding the full-length protein.  
      The PCR product derived by exon linking, covering the entire open reading frame, was cloned into the pCR2.1 vector from Invitrogen to provide clones used for expression and screening purposes.  
     Example C  
     Quantitative Expression Analysis of Clones in Various Cells and Tissues  
      The quantitative expression of various clones was assessed using microfiter plates containing RNA samples from a variety of normal and pathology-derived cells, cell lines and tissues using real time quantitative PCR (RTQ PCR). RTQ PCR was performed on an Applied Biosystems ABI PRISM® 7700 or an ABI PRISM® 7900 HT Sequence Detection System. Various collections of samples are assembled on the plates, and referred to as Panel 1 (containing normal tissues and cancer cell lines), Panel 2 (containing samples derived from tissues from normal and cancer sources), Panel 3 (containing cancer cell lines), Panel 4 (containing cells and cell lines from normal tissues and cells related to inflammatory conditions), Panel 5D/5I (containing human tissues and cell lines with an enphasis on metabolic diseases), AI_comprehensive_panel (containing normal tissue and samples from autoinflammatory diseases), Panel CNSD.01 (containing samples from normal and diseased brains) and CNS_neurodegeneration_panel (containing samples from normal and Alzheimer&#39;s diseased brains).  
      RNA integrity from all samples is controlled for quality by visual assessment of agarose gel electropherograms using 28S and 18S ribosomal RNA staining intensity ratio as a guide (2:1 to 2.5:1 28s:18s) and the absence of low molecular weight RNAs that would be indicative of degradation products. Samples are controlled against genomic DNA contamination by RTQ PCR reactions run in the absence of reverse transcriptase using probe and primer sets designed to amplify across the span of a single exon.  
      First, the RNA samples were normalized to reference nucleic acids such as constitutively expressed genes (for example, □-actin and GAPDH). Normalized RNA (5 ul) was converted to cDNA and analyzed by RTQ-PCR using One Step RT-PCR Master Mix Reagents (Applied Biosystems; Catalog No. 4309169) and gene-specific primers according to the manufacturer&#39;s instructions.  
      In other cases, non-normalized RNA samples were converted to single strand cDNA (sscDNA) using Superscript II (Invitrogen Corporation; Catalog No. 18064-147) and random hexamers according to the manufacturer&#39;s instructions. Reactions containing up to 10 □g of total RNA were performed in a volume of 20 □l and incubated for 60 minutes at 42° C. This reaction can be scaled up to 50 □g of total RNA in a final volume of 100 □l. sscDNA samples are then normalized to reference nucleic acids as described previously, using 1×TaqMan® Universal Master mix (Applied Biosystems; catalog No. 4324020), following the manufacturer&#39;s instructions.  
      Probes and primers were designed for each assay according to Applied Biosystems Primer Express Software package (version I for Apple Computer&#39;s Macintosh Power PC) or a similar algorithm using the target sequence as input. Default settings were used for reaction conditions and the following parameters were set before selecting primers: primer concentration=250 nM, primer melting temperature (T m ) range=58°-60° C., primer optimal Tm=59° C., maximum primer difference=2° C., probe does not have 5′ G, probe T m  must be 10° C. greater than primer Tm, amplicon size 75 bp to 100 bp. The probes and primers selected (see below) were synthesized by Synthegen (Houston, Tex., USA). Probes were double purified by HPLC to remove uncoupled dye and evaluated by mass spectroscopy to verify coupling of reporter and quencher dyes to the 5′ and 3′ ends of the probe, respectively. Their final concentrations were: forward and reverse primers, 900 nM each, and probe, 200 nM.  
      PCR conditions: When working with RNA samples, normalized RNA from each tissue and each cell line was spotted in each well of either a 96 well or a 384-well PCR plate (Applied Biosystems). PCR cocktails included either a single gene specific probe and primers set, or two multiplexed probe and primers sets (a set specific for the target clone and another gene-specific set multiplexed with the target probe). PCR reactions were set up using TaqMan® One-Step RT-PCR Master Mix (Applied Biosystems, Catalog No. 4313803) following manufacturer&#39;s instructions. Reverse transcription was performed at 48° C. for 30 minutes followed by amplification/PCR cycles as follows: 95° C. 10 min, then 40 cycles of 95° C. for 15 seconds, 60° C. for 1 minute. Results were recorded as CT values (cycle at which a given sample crosses a threshold level of fluorescence) using a log scale, with the difference in RNA concentration between a given sample and the sample with the lowest CT value being represented as 2 to the power of delta CT. The percent relative expression is then obtained by taking the reciprocal of this RNA difference and multiplying by 100. CT values below 28 indicate high expression, CT values between 28 and 32 indicate moderate expression, and CT values between 32 and 35 indicate low expression. CT values above 35 reflect levels of expression that are too low to be reliably measured.  
      When working with sscDNA samples, normalized sscDNA was used as described previously for RNA samples. PCR reactions containing one or two sets of probe and primers were set up as described previously, using 1×TaqMan® Universal Master mix (Applied Biosystems; catalog No. 4324020), following the manufacturer&#39;s instructions. PCR amplification was performed as follows: 95° C. 10 min, then 40 cycles of 95° C. for 15 seconds, 60° C. for 1 minute. Results were analyzed and processed as described previously.  
      Panels 1, 1.1, 1.2, and 1.3D  
      The plates for Panels 1, 1.1, 1.2 and 1.3D include 2 control wells (genomic DNA control and chemistry control) and 94 wells containing cDNA from various samples. The samples in these panels are broken into 2 classes: samples derived from cultured cell lines and samples derived from primary normal tissues. The cell lines are derived from cancers of the following types: lung cancer, breast cancer, melanoma, colon cancer, prostate cancer, CNS cancer, squamous cell carcinoma, ovarian cancer, liver cancer, renal cancer, gastric cancer and pancreatic cancer. Cell lines used in these panels are widely available through the American Type Culture Collection (ATCC), a repository for cultured cell lines, and were cultured using the conditions recommended by the ATCC. The normal tissues found on these panels are comprised of samples derived from all major organ systems from single adult individuals or fetuses. These samples are derived from the following organs: adult skeletal muscle, fetal skeletal muscle, adult heart, fetal heart, adult kidney, fetal kidney, adult liver, fetal liver, adult lung, fetal lung, various regions of the brain, the spleen, bone marrow, lymph node, pancreas, salivary gland, pituitary gland, adrenal gland, spinal cord, thymus, stomach, small intestine, colon, bladder, trachea, breast, ovary, uterus, placenta, prostate, testis and adipose.  
      In the results for Panels 1, 1.1, 1.2 and 1.3D, the following abbreviations are used: 
          ca.=carcinoma,     *=established from metastasis,     met=metastasis,     s cell var=small cell variant,     non-s=non-sm=non-small,     squam=squamous,     pl. elf=pl effusion=pleural effusion,     glio=glioma,     astro=astrocytoma, and     neuro=neuroblastoma.        

      GENERAL_SCREENING_PANEL_V1.4, V1.5, V1.6 AND 1.7  
      The plates for Panels 1.4, 1.5, 1.6 and 1.7 include 2 control wells (genomic DNA control and chemistry control) and 88 to 94 wells containing cDNA from various samples. The samples in Panels 1.4, 1.5, 1.6 and 1.7 are broken into 2 classes: samples derived from cultured cell lines and samples derived from primary normal tissues. The cell lines are derived from cancers of the following types: lung cancer, breast cancer, melanoma, colon cancer, prostate cancer, CNS cancer, squamous cell carcinoma, ovarian cancer, liver cancer, renal cancer, gastric cancer and pancreatic cancer. Cell lines used in Panels 1.4, 1.5, 1.6 and 1.7 are widely available through the American Type Culture Collection (ATCC), a repository for cultured cell lines, and were cultured using the conditions recommended by the ATCC. The normal tissues found on Panels 1.4, 1.5, 1.6 and 1.7 are comprised of pools of samples derived from all major organ systems from 2 to 5 different adult individuals or fetuses. These samples are derived from the following organs: adult skeletal muscle, fetal skeletal muscle, adult heart, fetal heart, adult kidney, fetal kidney, adult liver, fetal liver, adult lung, fetal lung, various regions of the brain, the spleen, bone marrow, lymph node, pancreas, salivary gland, pituitary gland, adrenal gland, spinal cord, thymus, stomach, small intestine, colon, bladder, trachea, breast, ovary, uterus, placenta, prostate, testis and adipose. Abbreviations are as described for Panels 1, 1.1, 1.2, and 1.3D.  
      Panels 2D, 2.2, 2.3, and 2.4  
      The plates for Panels 2D, 2.2, 2.3 and 2.4 generally include 2 control wells and 94 test samples composed of RNA or cDNA isolated from human tissue procured by surgeons working in close cooperation with the National Cancer Institute&#39;s Cooperative Human Tissue Network (CHTN) or the National Disease Research Initiative (NDRI) or from Ardais or Clinomics). The tissues are derived from human malignancies and in cases where indicated many malignant tissues have “matched margins” obtained from noncancerous tissue just adjacent to the tumor. These are termed normal adjacent tissues and are denoted “NAT” in the results below. The tumor tissue and the “matched margins” are evaluated by two independent pathologists (the surgical pathologists and again by a pathologist at NDRI/CHTN/Ardais/Clinomics). Unmatched RNA samples from tissues without malignancy (normal tissues) were also obtained from Ardais or Clinomics. This analysis provides a gross histopathological assessment of tumor differentiation grade. Moreover, most samples include the original surgical pathology report that provides information regarding the clinical stage of the patient. These matched margins are taken from the tissue surrounding (i.e. immediately proximal) to the zone of surgery (designated “NAT”, for normal adjacent tissue, in Table RR). In addition, RNA and cDNA samples were obtained from various human tissues derived from autopsies performed on elderly people or sudden death victims (accidents, etc.). These tissues were ascertained to be free of disease and were purchased from various commercial sources such as Clontech (Palo Alto, Calif.), Research Genetics, and Invitrogen.  
      HASS Panel V 1.0  
      The HASS panel v 1.0 plates are comprised of 93 cDNA samples and two controls. Specifically, 81 of these samples are derived from cultured human cancer cell lines that had been subjected to serum starvation, acidosis and anoxia for different time periods as well as controls for these treatments, 3 samples of human primary cells, 9 samples of malignant brain cancer (4 medulloblastomas and 5 glioblastomas) and 2 controls. The human cancer cell lines are obtained from ATCC (American Type Culture Collection) and fall into the following tissue groups: breast cancer, prostate cancer, bladder carcinomas, pancreatic cancers and CNS cancer cell lines. These cancer cells are all cultured under standard recommended conditions. The treatments used (serum starvation, acidosis and anoxia) have been previously published in the scientific literature. The primary human cells were obtained from Clonetics (Walkersville, Md.) and were grown in the media and conditions recommended by Clonetics. The malignant brain cancer samples are obtained as part of a collaboration (Henry Ford Cancer Center) and are evaluated by a pathologist prior to CuraGen receiving the samples. RNA was prepared from these samples using the standard procedures. The genomic and chemistry control wells have been described previously.  
      ARDAIS Panel V 1.0  
      The plates for ARDAIS panel v 1.0 generally include 2 control wells and 22 test samples composed of RNA isolated from human tissue procured by surgeons working in close cooperation with Ardais Corporation. The tissues are derived from human lung malignancies (lung adenocarcinoma or lung squamous cell carcinoma) and in cases where indicated many malignant samples have “matched margins” obtained from noncancerous lung tissue just adjacent to the tumor. These matched margins are taken from the tissue surrounding (i.e. immediately proximal) to the zone of surgery (designated “NAT”, for normal adjacent tissue) in the results below. The tumor tissue and the “matched margins” are evaluated by independent pathologists (the surgical pathologists and again by a pathologist at Ardais). Unmatched malignant and non-malignant RNA samples from lungs were also obtained from Ardais. Additional information from Ardais provides a gross histopathological assessment of tumor differentiation grade and stage. Moreover, most samples include the original surgical pathology report that provides information regarding the clinical state of the patient.  
      ARDAIS Prostate V 1.0  
      The plates for ARDAIS prostate 1.0 generally include 2 control wells and 68 test samples composed of RNA isolated from human tissue procured by surgeons working in close cooperation with Ardais Corporation. The tissues are derived from human prostate malignancies and in cases where indicated malignant samples have “matched margins” obtained from noncancerous prostate tissue just adjacent to the tumor. These matched margins are taken from the tissue surrounding (i.e. immediately proximal) to the zone of surgery (designated “NAT”, for normal adjacent tissue) in the results below. The tumor tissue and the “matched margins” are evaluated by independent pathologists (the surgical pathologists and again by a pathologist at Ardais). RNA from unmatched malignant and non-malignant prostate samples were also obtained from Ardais. Additional information from Ardais provides a gross histopathological assessment of tumor differentiation grade and stage. Moreover, most samples include the original surgical pathology report that provides information regarding the clinical state of the patient.  
      ARDAIS Kidney V 1.0  
      The plates for ARDAIS kidney 1.0 generally include 2 control wells and 44 test samples composed of RNA isolated from human tissue procured by surgeons working in close cooperation with Ardais Corporation. The tissues are derived from human prostate malignancies and in cases where indicated malignant samples have “matched margins” obtained from noncancerous prostate tissue just adjacent to the tumor. These matched margins are taken from the tissue surrounding (i.e. immediately proximal) to the zone of surgery (designated “NAT”, for normal adjacent tissue) in the results below. The tumor tissue and the “matched margins” are evaluated by independent pathologists (the surgical pathologists and again by a pathologist at Ardais). RNA from unmatched malignant and non-malignant prostate samples were also obtained from Ardais. Additional information from Ardais provides a gross histopathological assessment of tumor differentiation grade and stage. Moreover, most samples include the original surgical pathology report that provides information regarding the clinical state of the patient.  
      Panel 3D and 3.1 and 3.2  
      The plates of Panel 3D, 3.1, and 3.2 are comprised of 94 cDNA samples and two control samples. Specifically, 92 of these samples are derived from cultured human cancer cell lines, 2 samples of human primary cerebellar tissue and 2 controls. The human cell lines are generally obtained from ATCC (American Type Culture Collection), NCI or the German tumor cell bank and fall into the following tissue groups: Squamous cell carcinoma of the tongue, breast cancer, prostate cancer, melanoma, epidermoid carcinoma, sarcomas, bladder carcinomas, pancreatic cancers, kidney cancers, leukemnias/lymphomas, ovarian/uterine/cervical, gastric, colon, lung and CNS cancer cell lines. In addition, there are two independent samples of cerebellum. These cells are all cultured under standard recommended conditions and RNA extracted using the standard procedures. The cell lines in panel 3D, 3.1, 3.2, 1, 1.1., 1.2, 1.3D, 1.4, 1.5, and 1.6 are of the most common cell lines used in the scientific literature.  
      Panels 4D, 4R, and 4.1D  
      Panel 4 includes samples on a 96 well plate (2 control wells, 94 test samples) composed of RNA (Panel 4R) or cDNA (Panels 4D/4.1D) isolated from various human cell lines or tissues related to inflammatory conditions. Total RNA from control normal tissues such as colon and lung (Stratagene, La Jolla, Calif.) and thymus and kidney (Clontech) was employed. Total RNA from liver tissue from cirrhosis patients and kidney from lupus patients was obtained from BioChain (Biochain Institute, Inc., Hayward, Calif.). Intestinal tissue for RNA preparation from patients diagnosed as having Crohn&#39;s disease and ulcerative colitis was obtained from the National Disease Research Interchange (NDRI) (Philadelphia, Pa.).  
      Astrocytes, lung fibroblasts, dermal fibroblasts, coronary artery smooth muscle cells, small airway epithelium, bronchial epithelium, microvascular dermal endothelial cells, microvascular lung endothelial cells, human pulmonary aortic endothelial cells, human umbilical vein endothelial cells were all purchased from Clonetics (Walkersville, Md.) and grown in the media supplied for these cell types by Clonetics. These primary cell types were activated with various cytokines or combinations of cytokines for 6 and/or 12-14 hours, as indicated. The following cytokines were used; IL-1 beta at approximately 1-5 ng/ml, TNF alpha at approximately 5-10 ng/ml, IFN gamma at approximately 20-50 ng/ml, IL-4 at approximately 5-10 ng/ml, IL-9 at approximately 5-10 ng/ml, IL- 13 at approximately 5-10 ng/ml. Endothelial cells were sometimes starved for various times by culture in the basal media from Clonetics with 0.1% serum.  
      Mononuclear cells were prepared from blood of employees at CuraGen Corporation, using Ficoll. LAK cells were prepared from these cells by culture in DMEM 5% FCS (Hyclone), 100 μM non essential amino acids (Gibco/Life Technologies, Rockville, Md.), 1 mM sodium pyruvate (Gibco), mercaptoethanol 5.5×10 −5  M (Gibco), and 10 mM Hepes (Gibco) and Interleukin 2 for 4-6 days. Cells were then either activated with 10-20 ng/ml PMA and 1-2 μg/ml ionomycin, IL-12 at 5-10 ng/ml, IFN gamma at 20-50 ng/ml and IL-18 at 5-10 ng/ml for 6 hours. In some cases, mononuclear cells were cultured for 4-5 days in DMEM 5% FCS (Hyclone), 100 μM non essential amino acids (Gibco), 1 mM sodium pyruvate (Gibco), mercaptoethanol 5.5×10 −5  M (Gibco), and 10 mM Hepes (Gibco) with PHA (phytohemagglutinin) or PWM (pokeweed mitogen) at approximately 5 μg/ml. Samples were taken at 24, 48 and 72 hours for RNA preparation. MLR (mixed lymphocyte reaction) samples were obtained by taking blood from two donors, isolating the mononuclear cells using Ficoll and mixing the isolated mononuclear cells 1:1 at a final concentration of approximately 2×10 6  cells/mil in DMEM 5% FCS (Hyclone), 100 μM non essential amino acids (Gibco), 1 mM sodium pyruvate (Gibco), mercaptoethanol (5.5×10 −5  M) (Gibco), and 10 mM Hepes (Gibco). The MLR was cultured and samples taken at various time points ranging from 1-7 days for RNA preparation.  
      Monocytes were isolated from mononuclear cells using CD14 Miltenyi Beads, +ve VS selection columns and a Vario Magnet according to the manufacturer&#39;s instructions. Monocytes were differentiated into dendritic cells by culture in DMEM 5% fetal calf serum (FCS) (Hyclone, Logan, Utah), 100 μM non essential amino acids (Gibco), 1 mM sodium pyruvate (Gibco), mercaptoethanol 5.5×10 −5 M (Gibco), and 10 mM Hepes (Gibco), 50 ng/ml GMCSF and 5 ng/ml IL-4 for 5-7 days. Macrophages were prepared by culture of monocytes for 5-7 days in DMEM 5% FCS (Hyclone), 100 μm non essential amino acids (Gibco), 1 mM sodium pyruvate (Gibco), mercaptoethanol 5.5×10 −5  M (Gibco), 10 mM Hepes (Gibco) and 10% AB Human Serum or MCSF at approximately 50 ng/ml. Monocytes, macrophages and dendritic cells were stimulated for 6 and 12-14 hours with lipopolysaccharide (LPS) at 100 ng/ml. Dendritic cells were also stimulated with anti-CD40 monoclonal antibody (Pharmingen) at 10 μg/ml for 6 and 12-14 hours.  
      CD4 lymphocytes, CD8 lymphocytes and NK cells were also isolated from mononuclear cells using CD4, CD8 and CD56 Miltenyi beads, positive VS selection columns and a Vario Magnet according to the manufacturer&#39;s instructions. CD45RA and CD45RO CD4 lymphocytes were isolated by depleting mononuclear cells of CD8, CD56, CD14 and CD19 cells using CD8, CD56, CD14 and CD19 Miltenyi beads and positive selection. CD45RO beads were then used to isolate the CD45RO CD4 lymphocytes with the remaining cells being CD45RA CD4 lymphocytes. CD45RA CD4, CD45RO CD4 and CD8 lymphocytes were placed in DMEM 5% FCS (Hyclone), 100 μM non essential amino acids (Gibco), 1 mM sodium pyruvate (Gibco), mercaptoethanol 5.5×10 −5  M (Gibco), and 10 mM Hepes (Gibco) and plated at 10 6  cells/ml onto Falcon 6 well tissue culture plates that had been coated overnight with 0.5 μg/ml anti-CD28 (Pharmingen) and 3 ug/fffl anti-CD3 (OKT3, ATCC) in PBS. After 6 and 24 hours, the cells were harvested for RNA preparation. To prepare chronically activated CD8 lymphocytes, we activated the isolated CD8 lymphocytes for 4 days on anti-CD28 and anti-CD3 coated plates and then harvested the cells and expanded them in DMEM 5% FCS (Hyclone), 100 μM non essential amino acids (Gibco), 1 mM sodium pyruvate (Gibco), mercaptoethanol 5.5×10 −5  M (Gibco), and 10 mM Hepes (Gibco) and EL-2. The expanded CD8 cells were then activated again with plate bound anti-CD3 and anti-CD28 for 4 days and expanded as before. RNA was isolated 6 and 24 hours after the second activation and after 4 days of the second expansion culture. The isolated NK cells were cultured in DMEM 5% FCS (Hyclone), 100 μM non essential amino acids (Gibco), 1 mM sodium pyruvate (Gibco), mercaptoethanol 5.5×10 −5  M (Gibco), and 10 mM Hepes (Gibco) and IL-2 for 4-6 days before RNA was prepared.  
      To obtain B cells, tonsils were procured from NDRI. The tonsil was cut up with sterile dissecting scissors and then passed through a sieve. Tonsil cells were then spun down and resupended at 10 6  cells/ml in DMEM 5% FCS (Hyclone), 100 μM non essential amino acids (Gibco), 1 mM sodium pyruvate (Gibco), mercaptoethanol 5.5×10 −5  M (Gibco), and 10 mM Hepes (Gibco). To activate the cells, we used PWM at 5 μg/ml or anti-CD40 (Pharmingen) at approximately 10 μg/ml and IL-4 at 5-10 ng/ml. Cells were harvested for RNA preparation at 24,48 and 72 hours.  
      To prepare the primary and secondary Th1/Th2 and Tr1 cells, six-well Falcon plates were coated overnight with 10 μg/ml anti-CD28 (Pharmingen) and 2 μg/ml OKT3 (ATCC), and then washed twice with PBS. Umbilical cord blood CD4 lymphocytes (Poietic Systems, German Town, Md.) were cultured at 10 5 -10 6  cells/ml in DMEM 5% FCS (Hyclone), 100 μM non essential amino acids (Gibco), 1 mM sodium pyruvate (Gibco), mercaptoethanol 5.5×10 −5  M (Gibco), 10 mM Hepes (Gibco) and IL-2 (4 ng/ml). IL-12 (5 ng/ml) and anti-IL4 (1 □g/ml) were used to direct to Th1, while IL-4 (5 ng/ml) and anti-IFN gamma (1 □g/ml) were used to direct to Th2 and IL-10 at 5 ng/ml was used to direct to Tr1. After 4-5 days, the activated Th1, Th2 and Tr1 lymphocytes were washed once in DMEM and expanded for 4-7 days in DMEM 5% FCS (Hyclone), 100 μM non essential amino acids (Gibco), 1 mM sodium pyruvate (Gibco), mercaptoethanol 5.5×10 −5  M (Gibco), 10 mM Hepes (Gibco) and IL-2 (1 ng/ml). Following this, the activated Th1, Th2 and Tr1 lymphocytes were re-stimulated for 5 days with anti-CD28/OKT3 and cytokines as described above, but with the addition of anti-CD95L (1 □g/ml) to prevent apoptosis. After 4-5 days, the Th1, Th2 and Tr1 lymphocytes were washed and then expanded again with IL-2 for 4-7 days. Activated Th1 and Tb2 lymphocytes were maintained in this way for a maximum of three cycles. RNA was prepared from primary and secondary Th1, Th2 and Tr1 after 6 and 24 hours following the second and third activations with plate bound anti-CD3 and anti-CD28 mAbs and 4 days into the second and third expansion cultures in Interleukin 2.  
      The following leukocyte cells lines were obtained from the ATCC: Ramos, EOL-1, KU-812. EOL cells were further differentiated by culture in 0.1 mM dbcAMP at 5×10 5  cells/ml for 8 days, changing the media every 3 days and adjusting the cell concentration to 5×10 5  cells/ml. For the culture of these cells, we used DMEM or RPMI (as recommended by the ATCC), with the addition of 5% FCS (Hyclone), 100 μM non essential amino acids (Gibco), 1 mM sodium pyruvate (Gibco), mercaptoethanol 5.5×10 −5  M (Gibco), 10 mM Hepes (Gibco). RNA was either prepared from resting cells or cells activated with PMA at 10 ng/ml and ionomycin at 1 μg/ml for 6 and 14 hours. Keratinocyte line CCD106 and an airway epithelial tumor line NCI-H292 were also obtained from the ATCC. Both were cultured in DMEM 5% FCS (Hyclone), 100 μM non essential amino acids (Gibco), 1 mM sodium pyruvate (Gibco), mercaptoethanol 5.5×10 −5  M (Gibco), and 10 mM Hepes (Gibco). CCD1106 cells were activated for 6 and 14 hours with approximately 5 ng/ml TNF alpha and 1 ng/ml IL-1 beta, while NCI-H292 cells were activated for 6 and 14 hours with the following cytokines: 5 ng/ml IL-4, 5 ng/ml IL-9, 5 ng/ml IL-13 and 25 ng/ml IFN gamma.  
      For these cell lines and blood cells, RNA was prepared by lysing approximately 10 7  cells/ml using Trizol (Gibco BRL). Briefly, 1/10 volume of bromochloropropane (Molecular Research Corporation) was added to the RNA sample, vortexed and after 10 minutes at room temperature, the tubes were spun at 14,000 rpm in a Sorvall SS34 rotor. The aqueous phase was removed and placed in a 15 ml Falcon Tube. An equal volume of isopropanol was added and left at −20 degrees C. overnight. The precipitated RNA was spun down at 9,000 rpm for 15 min in a Sorvall SS34 rotor and washed in 70% ethanol. The pellet was redissolved in 300 μl of RNAse-free water and 35 μl buffer (Promega) 5 μl DTT, 7 μl RNAsin and 8 μl DNAse were added. The tube was incubated at 37 degrees C. for 30 minutes to remove contaminating genomic DNA, extracted once with phenol chloroform and re-precipitated with 1/10 volume of 3 M sodium acetate and 2 volumes of 100% ethanol. The RNA was spun down and placed in RNAse free water. RNA was stored at −80 degrees C.  
      AI_comprehensive Panel_v1.0  
      The plates for AI_comprehensive_panel_v1.0 include two control wells and 89 test samples comprised of cDNA isolated from surgical and postmortem human tissues obtained from the Backus Hospital and Clinomics (Frederick, Md.). Total RNA was extracted from tissue samples from the Backus Hospital in the Facility at CuraGen. Total RNA from other tissues was obtained from Clinomics.  
      Joint tissues including synovial fluid, synovium, bone and cartilage were obtained from patients undergoing total knee or hip replacement surgery at the Backus Hospital. Tissue samples were immediately snap frozen in liquid nitrogen to ensure that isolated RNA was of optimal quality and not degraded. Additional samples of osteoarthritis and rheumatoid arthritis joint tissues were obtained from Clinomics. Normal control tissues were supplied by Clinomics and were obtained during autopsy of trauma victims.  
      Surgical specimens of psoriatic tissues and adjacent matched tissues were provided as total RNA by Clinomics. Two male and two female patients were selected between the ages of 25 and 47. None of the patients were taking prescription drugs at the time samples were isolated.  
      Surgical specimens of diseased colon from patients with ulcerative colitis and Crohns disease and adjacent matched tissues were obtained from Clinomics. Bowel tissue from three female and three male Crohn&#39;s patients between the ages of 41-69 were used. Two patients were not on prescription medication while the others were taking dexamethasone, phenobarbital, or tylenol. Ulcerative colitis tissue was from three male and four female patients. Four of the patients were taking lebvid and two were on phenobarbital.  
      Total RNA from post mortem lung tissue from trauma victims with no disease or with emphysema, asthma or COPD was purchased from Clinomics. Emphysema patients ranged in age from 40-70 and all were smokers, this age range was chosen to focus on patients with cigarette-linked emphysema and to avoid those patients with alpha-1anti-trypsin deficiencies. Asthma patients ranged in age from 36-75, and excluded smokers to prevent those patients that could also have COPD. COPD patients ranged in age from 35-80 and included both smokers and non-smokers. Most patients were taking corticosteroids, and bronchodilators.  
      In the labels employed to identify tissues in the AI_comprehensive panel_v1.0 panel, the following abbreviations are used: 
          AI=Autoimmunity     Syn=Synovial     Normal=No apparent disease     Rep22/Rep20=individual patients     RA=Rheumatoid arthritis 
            Backus=From Backus Hospital     OA=Osteoarthritis    
            (SS) (BA) (MF)=Individual patients     Adj=Adjacent tissue     Match control=adjacent tissues     -M=Male     -F=Female     COPD=Chronic obstructive pulmonary disease        

      AI.05 Chondrosarcoma  
      The AI.05 chondrosarcoma plates are comprised of SW1353 cells that had been subjected to serum starvation and treatment with cytokines that are known to induce MMP (1, 3 and 13) synthesis (eg. IL1 beta). These treatments include: IL-1□ (10 ng/ml), IL-1□+ TNF-□ (50 ng/ml), IL-1□+ Oncostatin (50 ng/ml) and PMA(100 ng/ml). The SW1353 cells were obtained from the ATCC (American Type Culture Collection) and were all cultured under standard recommended conditions. The SW1353 cells were plated at 3×10 5  cells/ml (in DMEM medium-10% FBS) in 6-well plates. The treatment was done in triplicate, for 6 and 18 h. The supernatants were collected for analysis of MMP 1, 3 and 13 production and for RNA extraction. RNA was prepared from these samples using the standard procedures.  
      Panels 5D and 5I  
      The plates for Panel 5D and 5I include two control wells and a variety of cDNAs isolated from human tissues and cell lines with an emphasis on metabolic diseases. Metabolic tissues were obtained from patients enrolled in the Gestational Diabetes study. Cells were obtained during different stages in the differentiation of adipocytes from human mesenchymal stem cells. Human pancreatic islets were also obtained.  
      In the Gestational Diabetes study subjects are young (18-40 years), otherwise healthy women with and without gestational diabetes undergoing routine (elective) Caesarean section. After delivery of the infant, when the surgical incisions were being repaired/closed, the obstetrician removed a small sample (&lt;1 cc) of the exposed metabolic tissues during the closure of each surgical level. The biopsy material was rinsed in sterile saline, blotted and fast frozen within 5 minutes from the time of removal. The tissue was then flash frozen in liquid nitrogen and stored, individually, in sterile screw-top tubes and kept on dry ice for shipment to or to be picked up by CuraGen. The metabolic tissues of interest include uterine wall (smooth muscle), visceral adipose, skeletal muscle (rectus) and subcutaneous adipose. Patient descriptions are as follows:  
                                                      Patient 2   Diabetic Hispanic, overweight, not on insulin           Patient 7-9   Nondiabetic Caucasian and obese (BMI &gt; 30)           Patient 10   Diabetic Hispanic, overweight, on insulin           Patient 11   Nondiabetic African American and overweight           Patient 12   Diabetic Hispanic on insulin                      
 
      Adipocyte differentiation was induced in donor progenitor cells obtained from Osirus (a division of Clonetics/BioWhittaker) in triplicate, except for Donor 3U which had only two replicates. Scientists at Clonetics isolated, grew and differentiated human mesenchymal stem cells (HuMSCs) for CuraGen based on the published protocol found in Mark F. Pittenger, et al., Multilineage Potential of Adult Human Mesenchymal Stem Cells  Science Apr.  2, 1999: 143-147. Clonetics provided Trizol lysates or frozen pellets suitable for mRNA isolation and ds cDNA production. A general description of each donor is as follows:  
                                              Donor 2 and 3   U   Mesenchymal   Undifferentiated Adipose               Stem cells       Donor 2 and 3   AM   Adipose   Adipose Midway Differentiated       Donor 2 and 3   AD   Adipose   Adipose Differentiated                  
 
      Human cell lines were generally obtained from ATCC (American Type Culture Collection), NCI or the German tumor cell bank and fall into the following tissue groups: kidney proximal convoluted tubule, uterine smooth muscle cells, small intestine, liver HepG2 cancer cells, heart primary stromal cells, and adrenal cortical adenoma cells. These cells are all cultured under standard recommended conditions and RNA extracted using the standard procedures. All samples were processed at CuraGen to produce single stranded cDNA.  
      Panel 5I contains all samples previously described with the addition of pancreatic islets from a 58 year old female patient obtained from the Diabetes Research Institute at the University of Miami School of Medicine. Islet tissue was processed to total RNA at an outside source and delivered to CuraGen for addition to panel 5I.  
      In the labels employed to identify tissues in the 5D and 5I panels, the following abbreviations are used: 
          GO Adipose=Greater Omentum Adipose     SK=Skeletal Muscle     UT=Uterus     PL=Placenta     AD=Adipose Differentiated     AM=Adipose Midway Differentiated     U=Undifferentiated Stem Cells        

      Human Metabolic RTQ-PCR Panel  
      The plates for the Human Metabolic RTQ-PCR Panel include two control wells (genomic DNA control and chemistry control) and 211 cDNAs isolated from human tissues and cell lines with an emphasis on metabolic diseases. This panel is useful for establishing the tissue and cellular expression profiles for genes believed to play a role in the etiology and pathogenesis of obesity and/or diabetes and to confirm differential expression of such genes derived from other methods.  
      Metabolic tissues were obtained from patients enrolled in the CuraGen Gestational Diabetes study and from autopsy tissues from Type II diabetics and age, sex and race-matched control patients. One or more of the following were used to characterize the patients: body mass index [BMI=wt (kg)/ht (m 2 )], serum glucose, HgbA1c. Cell lines used in this panel are widely available through the American Type Culture Collection (ATCC), a repository for cultured cell lines. RNA from human Pancreatic Islets was also obtained.  
      In the Gestational Diabetes study, subjects are young (18-40 years), otherwise healthy women with and without gestational diabetes undergoing routine (elective) Caesarian section. After delivery of the infant, when the surgical incisions were being repaired/closed, the obstetrician removed a small sample (&lt;1 cc) of the exposed metabolic tissues during the closure of each surgical level. The biopsy material was rinsed in sterile saline, blotted, and then flash frozen in liquid nitrogen and stored, individually, in sterile screw-top tubes and kept on dry ice for shipment to or to be picked up by CuraGen. The metabolic tissues of interest include uterine wall (smooth muscle), visceral adipose, skeletal muscle (rectus), and subcutaneous adipose. Patient descriptions are as follows:  
                                      Patient 7   Non-diabetic Caucasian and obese       Patient 8   Non-diabetic Caucasian and obese       Patient 12   Diabetic Caucasian with unknown BMI and on insulin       Patient 13   Diabetic Caucasian, overweight, not on insulin       Patient 15   Diabetic Caucasian, obese, not on insulin       Patient 17   Diabetic Caucasian, normal weight, not on insulin       Patient 18   Diabetic Hispanic, obese, not on insulin       Patient 19   Non-diabetic Caucasian and normal weight       Patient 20   Diabetic Caucasian, overweight, and on insulin       Patient 21   Non-diabetic Caucasian and overweight       Patient 22   Diabetic Caucasian, normal weight, on insulin       Patient 23   Non-diabetic Caucasian and overweight       Patient 25   Diabetic Caucasian, normal weight, not on insulin       Patient 26   Diabetic Caucasian, obese, on insulin       Patient 27   Diabetic Caucasian, obese, on insulin                  
 
      Total RNA was isolated from metabolic tissues of 12 Type II diabetic patients and 12 matched control patients included hypothalamus, liver, pancreas, small intestine, psoas muscle, diaphragm muscle, visceral adipose, and subcutaneous adipose. The diabetics and non-diabetics were matched for age, sex, ethnicity, and BMI where possible.  
      The panel also contains pancreatic islets from a 22 year old male patient (with a BMI of 35) obtained from the Diabetes Research Institute at the University of Miami School of Medicine. Islet tissue was processed to total RNA at CuraGen.  
      Cell lines used in this panel are widely available through the American Type Culture Collection (ATCC), a repository for cultured cell lines, and were cultured at an outside facility. The RNA was extracted at CuraGen according to CuraGen protocols. All samples were then processed at CuraGen to produce single stranded cDNA.  
      In the labels used to identify tissues in the Human Metabolic panel, the following abbreviations are used:  
                               Panel CNSD.01                                                Pl =   placenta           Go =   greater omentum           Sk =   skeletal muscle           Ut =   uterus           CC =   Caucasian           HI =   Hispanic           AA =   African American           AS =   Asian           Diab =   Type II diabetic           Norm =   Non-diabetic           Overwt =   Overweight; med BMI           Obese =   Hi BMI           Low BM =   20-25           Med BM =   26-30           Hi BMI =   Greater than 30           M =   Male           # =   Patient identifier           Vis. =   Visceral           SubQ =   Subcutaneous                      
 
      The plates for Panel CNSD.01 include two control wells and 94 test samples comprised of cDNA isolated from postmortem human brain tissue obtained from the Harvard Brain Tissue Resource Center. Brains are removed from calvaria of donors between 4 and 24 hours after death, sectioned by neuroanatomists, and frozen at −80° C. in liquid nitrogen vapor. All brains are sectioned and examined by neuropathologists to confirm diagnoses with clear associated neuropathology.  
      Disease diagnoses are taken from patient records. The panel contains two brains from each of the following diagnoses: Alzheimer&#39;s disease, Parkinson&#39;s disease, Huntington&#39;s disease, Progressive Supernuclear Palsy, Depression, and “Normal controls”. Within each of these brains, the following regions are represented: cingulate gyrus, temporal pole, globus palladus, substantia nigra, Brodman Area 4 (primary motor strip), Brodman Area 7 (parietal cortex), Brodman Area 9 (prefrontal cortex), and Brodman area 17 (occipital cortex). Not all brain regions are represented in all cases; e.g., Huntington&#39;s disease is characterized in part by neurodegeneration in the globus palladus, thus this region is impossible to obtain from confirmed Huntington&#39;s cases. Likewise Parkinson&#39;s disease is characterized by degeneration of the substantia nigra making this region more difficult to obtain. Normal control brains were examined for neuropathology and found to be free of any pathology consistent with neurodegeneration.  
      In the labels employed to identify tissues in the CNS panel, the following abbreviations are used: 
          PSP=Progressive supranuclear palsy     Sub Nigra=Substantia nigra     Glob Palladus=Globus palladus     Temp Pole=Temporal pole     Cing Gyr=Cingulate gyrus     BA 4=Brodman Area 4        

      Panel CNS_Neurodegeneration_V1.0  
      The plates for Panel CNS_Neurodegeneration_V1.0 include two control wells and 47 test samples comprised of cDNA isolated from postmortem human brain tissue obtained from the Harvard Brain Tissue Resource Center (McLean Hospital) and the Human Brain and Spinal Fluid Resource Center (VA Greater Los Angeles Healthcare System). Brains are removed from calvaria of donors between 4 and 24 hours after death, sectioned by neuroanatomists, and frozen at −80° C. in liquid nitrogen vapor. All brains are sectioned and examined by neuropathologists to confirm diagnoses with clear associated neuropathology.  
      Disease diagnoses are taken from patient records. The panel contains six brains from Alzheimer&#39;s disease (AD) patients, and eight brains from “Normal controls” who showed no evidence of dementia prior to death. The eight normal control brains are divided into two categories: Controls with no dementia and no Alzheimer&#39;s like pathology (Controls) and controls with no dementia but evidence of severe Alzheimer&#39;s like pathology, (specifically senile plaque load rated as level 3 on a scale of 0-3; 0=no evidence of plaques, 3=severe AD senile plaque load). Within each of these brains, the following regions are represented: hippocampus, temporal cortex (Brodman Area 21), parietal cortex (Brodman area 7), and occipital cortex (Brodman area 17). These regions were chosen to encompass all levels of neurodegeneration in AD. The hippocampus is a region of early and severe neuronal loss in AD; the temporal cortex is known to show neurodegeneration in AD after the hippocampus; the parietal cortex shows moderate neuronal death in the late stages of the disease; the occipital cortex is spared in AD and therefore acts as a “control” region within AD patients. Not all brain regions are represented in all cases.  
      In the labels employed to identify tissues in the CNS_Neurodegeneration_V1.0 panel, the following abbreviations are used: 
          AD=Alzheimer&#39;s disease brain; patient was demented and showed AD-like pathology upon autopsy     Control=Control brains; patient not demented, showing no neuropathology     Control (Path)=Control brains; pateint not demented but showing sever AD-like pathology     SupTemporal Ctx=Superior Temporal Cortex     Inf Temporal Ctx=Inferior Temporal Cortex        

      The expression of the gene was analyzed after normalization using scaling factor. The scaling factor is calculated from the Grand mean of CT values for a panel and the Well mean which is specific to the tissue. The Grand mean is the average CT value for all wells across all runs. For example, if a panel has 50 samples and has had 100 probe/primer sets run on it, the grand mean would be the average of these 5000 CT scores. The well mean is tissue-specific. On the above described panel there would be 50 different well means, each taking the average of the 100 CT values generated for each sample on the panel from the 100 probe/primer sets.  
      The asumption is that across a large number of genes, all samples should have the same CT value. If a well is lower than the average across a large number of genes, it is “scaled up” by that difference or the “scaling factor”.  
      Scaling Factor=Grand mean−Well mean  
      The new CT value for the well is:  
      Scaled CT value=Raw CT+Scaling Factor.  
      Statistical Analysis of CNS_Neurodegeneration_V1.0 Data  
      All data were analyzed by analysis of covariance (ANCOVA). As a covariate, the average CT value (or number of rounds of PCR until signal from the well was detected) was calculated for 1000 PCR runs on different genes. This number is therefore an estimate of total cDNA quantity and quality for each sample. When RTQ PCR is run for a given gene, CT values are therefore compared to these average values to correct for differences in well loading or original RNA quality. Stats were run on data from the temporal cortex, as this regions shows sever neurodegeneration in the mid to late stages of the disease, and because the largest number of samples were available for this region giving the most statistical power. Covariates for each well corresponding to Temporal Cortex samples are listed below. The well numbers (10-25) are listed under “Order” in the table of CT values given for each gene run. For this analysis, Controls and Control (Path) cases were grouped together as the intention was to find genes associated with dementia as opposed to amyloid deposition.  
                               Panel CNS_Neurodegeneration_V2.0                                                    10   AD1   33.014           11   AD2   32.309           12   AD3   34.195           13   AD4   32.689           14   AD5 Inf   30.829           15   AD5 Sup   31.519           16   AD6 Inf   31.517           17   AD6 Sup   31.415           18   Con1   34.236           19   Con2   32.352           20   Con3   33.215           21   Con4   33.661           22   Con5 (Path)   31.685           23   Con6 (Path)   32.187           24   Con7 (Path)   34.427           25   Con8 (Path)   32.238                      
 
      The plates for Panel CNS_Neurodegeneration_V2.0 include two control wells and 47 test samples comprised of cDNA isolated from postmortem human brain tissue obtained from the Harvard Brain Tissue Resource Center (McLean Hospital) and the Human Brain and Spinal Fluid Resource Center (VA Greater Los Angeles Healthcare System). Brains are removed from calvaria of donors between 4 and 24 hours after death, sectioned by neuroanatomists, and frozen at −80° C. in liquid nitrogen vapor. All brains are sectioned and examined by neuropathologists to confirm diagnoses with clear associated neuropathology.  
      Disease diagnoses are taken from patient records. The panel contains sixteen brains from Alzheimer&#39;s disease (AD) patients, and twenty-nine brains from “Normal controls” who showed no evidence of dementia prior to death. The twenty-nine normal control brains are divided into two categories: Fourteen controls with no dementia and no Alzheimer&#39;s like pathology (Controls) and fifteen controls with no dementia but evidence of severe Alzheimer&#39;s like pathology, (specifically senile plaque load rated as level 3 on a scale of 0-3; 0=no evidence of plaques, 3=severe AD senile plaque load). Tissue from the temporal cotex (Broddmann Area 21) was selected for all samples from the Harvard Brain Tissue Resource Center; from the two sample from the Human Brain and Spinal Fluid Resource Center (samples 1 and 2) tissue from the inferior and superior temporal cortex was used; each sample on the panel represents a pool of inferior and superior temporal cortex from an individual patient. The temporal cortex was chosen as it shows a loss of neurons in the intermediate stages of the disease. Selection of a region which is affected in the early stages of Alzheimer&#39;s disease (e.g., hippocampus or entorhinal cortex) could potentially result in the examination of gene expression after vulnerable neurons are lost, and missing genes involved in the actual neurodegeneration process.  
      In the labels employed to identify tissues in the CNS_Neurodegeneration_V2.0 panel, the following abbreviations are used: 
          AD=Alzheimer&#39;s disease brain; patient was demented and showed AD-like pathology upon autopsy     Control=Control brains; patient not demented, showing no neuropathology 
            AH3=Control brains; pateint not demented but showing sever AD-like pathology    
            Inf &amp; Sup Temp Ctx Pool=Pool of inferior and superior temporal cortex for a given individual        

      A. CG50253-01: Epidermal Growth Factor  
      Expression of full-length physical clone CG50253-01 was assessed using the primer-probe set Ag2505, described in Table AA. Results of the RTQ-PCR runs are shown in Tables AB, AC, AD, AE, AF and AG.  
                   TABLE AA                          Probe Name Ag2505                                                     Start   SEQ ID           Primers   Sequences   Length   Position No                                             Forward   5′-aaagaaggataccagggtgatg-3′   22   969   1213                   Probe   TET-5′-atgattgaaccttcaggtccaattca-3′   26   1020   1214               Reverse   5′-ggtaccatttccctttggtaca-3′   22   1046   1215                  
 
     
       
         
           
               
             
               
                 TABLE AB 
               
             
            
               
                   
               
               
                   
               
               
                 AI_comprehensive panel_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 110967 COPD-F 
                 15.3 
               
               
                   
                 110980 COPD-F 
                 11.8 
               
               
                   
                 110968 COPD-M 
                 8.9 
               
               
                   
                 110977 COPD-M 
                 28.1 
               
               
                   
                 110989 Emphysema-F 
                 9.6 
               
               
                   
                 110992 Emphysema-F 
                 1.9 
               
               
                   
                 110993 Emphysema-F 
                 7.7 
               
               
                   
                 110994 Emphysema-F 
                 5.2 
               
               
                   
                 110995 Emphysema-F 
                 3.6 
               
               
                   
                 110996 Emphysema-F 
                 0.4 
               
               
                   
                 110997 Asthma-M 
                 4.6 
               
               
                   
                 111001 Asthma-F 
                 2.3 
               
               
                   
                 111002 Asthma-F 
                 3.5 
               
               
                   
                 111003 Atopic Asthma-F 
                 22.5 
               
               
                   
                 111004 Atopic Asthma-F 
                 10.4 
               
               
                   
                 111005 Atopic Asthma-F 
                 7.3 
               
               
                   
                 111006 Atopic Asthma-F 
                 1.6 
               
               
                   
                 111417 Allergy-M 
                 5.1 
               
               
                   
                 112347 Allergy-M 
                 1.4 
               
               
                   
                 112349 Normal Lung-F 
                 0.7 
               
               
                   
                 112357 Normal Lung-F 
                 7.1 
               
               
                   
                 112354 Normal Lung-M 
                 7.6 
               
               
                   
                 112374 Crohns-F 
                 9.0 
               
               
                   
                 112389 Match Control Crohns-F 
                 11.2 
               
               
                   
                 112375 Crohns-F 
                 10.2 
               
               
                   
                 112732 Match Control Crohns-F 
                 1.2 
               
               
                   
                 112725 Crohns-M 
                 0.9 
               
               
                   
                 112387 Match Control Crohns-M 
                 11.4 
               
               
                   
                 112378 Crohns-M 
                 1.3 
               
               
                   
                 112390 Match Control Crohns-M 
                 16.7 
               
               
                   
                 112726 Crohns-M 
                 21.8 
               
               
                   
                 112731 Match Control Crohns-M 
                 15.3 
               
               
                   
                 112380 Ulcer Col-F 
                 5.8 
               
               
                   
                 112734 Match Control Ulcer Col-F 
                 3.7 
               
               
                   
                 112384 Ulcer Col-F 
                 19.2 
               
               
                   
                 112737 Match Control Ulcer Col-F 
                 13.5 
               
               
                   
                 112386 Ulcer Col-F 
                 8.4 
               
               
                   
                 112738 Match Control Ulcer Col-F 
                 3.8 
               
               
                   
                 112381 Ulcer Col-M 
                 5.0 
               
               
                   
                 112735 Match Control Ulcer Col-M 
                 9.7 
               
               
                   
                 112382 Ulcer Col-M 
                 11.7 
               
               
                   
                 112394 Match Control Ulcer Col-M 
                 3.1 
               
               
                   
                 112383 Ulcer Col-M 
                 5.1 
               
               
                   
                 112736 Match Control Ulcer Col-M 
                 5.0 
               
               
                   
                 112423 Psoriasis-F 
                 14.0 
               
               
                   
                 112427 Match Control Psoriasis-F 
                 16.7 
               
               
                   
                 112418 Psoriasis-M 
                 14.0 
               
               
                   
                 112723 Match Control Psoriasis-M 
                 0.2 
               
               
                   
                 112419 Psoriasis-M 
                 18.2 
               
               
                   
                 112424 Match Control Psoriasis-M 
                 6.8 
               
               
                   
                 112420 Psoriasis-M 
                 13.9 
               
               
                   
                 112425 Match Control Psoriasis-M 
                 13.6 
               
               
                   
                 104689 (MF) OA Bone-Backus 
                 25.3 
               
               
                   
                 104690 (MF) Adj “Normal” Bone-Backus 
                 27.9 
               
               
                   
                 104691 (MF) OA Synovium-Backus 
                 2.9 
               
               
                   
                 104692 (BA) OA Cartilage-Backus 
                 0.0 
               
               
                   
                 104694 (BA) OA Bone-Backus 
                 5.8 
               
               
                   
                 104695 (BA) Adj “Normal” Bone-Backus 
                 14.1 
               
               
                   
                 104696 (BA) OA Synovium-Backus 
                 2.3 
               
               
                   
                 104700 (SS) OA Bone-Backus 
                 28.9 
               
               
                   
                 104701 (SS) Adj “Normal” Bone-Backus 
                 25.5 
               
               
                   
                 104702 (SS) OA Synovium-Backus 
                 11.7 
               
               
                   
                 117093 OA Cartilage Rep7 
                 7.5 
               
               
                   
                 112672 OA Bone5 
                 19.2 
               
               
                   
                 112673 OA Synovium5 
                 6.4 
               
               
                   
                 112674 OA Synovial Fluid cells5 
                 6.8 
               
               
                   
                 117100 OA Cartilage Rep14 
                 1.9 
               
               
                   
                 112756 OA Bone9 
                 26.4 
               
               
                   
                 112757 OA Synovium9 
                 2.8 
               
               
                   
                 112758 OA Synovial Fluid Cells9 
                 8.1 
               
               
                   
                 117125 RA Cartilage Rep2 
                 14.8 
               
               
                   
                 113492 Bone2 RA 
                 84.7 
               
               
                   
                 113493 Synovium2 RA 
                 40.9 
               
               
                   
                 113494 Syn Fluid Cells RA 
                 61.1 
               
               
                   
                 113499 Cartilage4 RA 
                 90.1 
               
               
                   
                 113500 Bone4 RA 
                 100.0 
               
               
                   
                 113501 Synovium4 RA 
                 71.2 
               
               
                   
                 113502 Syn Fluid Cells4 RA 
                 48.6 
               
               
                   
                 113495 Cartilage3 RA 
                 77.9 
               
               
                   
                 113496 Bone3 RA 
                 92.0 
               
               
                   
                 113497 Synovium3 RA 
                 53.6 
               
               
                   
                 113498 Syn Fluid Cells3 RA 
                 98.6 
               
               
                   
                 117106 Normal Cartilage Rep20 
                 3.0 
               
               
                   
                 113663 Bone3 Normal 
                 2.0 
               
               
                   
                 113664 Synovium3 Normal 
                 0.5 
               
               
                   
                 113665 Syn Fluid Cells3 Normal 
                 1.6 
               
               
                   
                 117107 Normal Cartilage Rep22 
                 3.7 
               
               
                   
                 113667 Bone4 Normal 
                 4.3 
               
               
                   
                 113668 Synovium4 Normal 
                 9.1 
               
               
                   
                 113669 Syn Fluid Cells4 Normal 
                 6.6 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2505, Run 248588456    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AC 
               
             
            
               
                   
               
               
                   
               
               
                 CNS_neurodegeneration_v1.0 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 AD 1 Hippo 
                 38.7 
                 51.4 
               
               
                   
                 AD 2 Hippo 
                 48.0 
                 64.6 
               
               
                   
                 AD 3 Hippo 
                 18.8 
                 30.6 
               
               
                   
                 AD 4 Hippo 
                 34.6 
                 33.0 
               
               
                   
                 AD 5 Hippo 
                 36.9 
                 39.2 
               
               
                   
                 AD 6 Hippo 
                 100.0 
                 97.9 
               
               
                   
                 Control 2 Hippo 
                 26.8 
                 33.7 
               
               
                   
                 Control 4 Hippo 
                 39.8 
                 52.5 
               
               
                   
                 Control (Path) 3 Hippo 
                 18.4 
                 21.8 
               
               
                   
                 AD 1 Temporal Ctx 
                 48.6 
                 58.6 
               
               
                   
                 AD 2 Temporal Ctx 
                 45.1 
                 43.2 
               
               
                   
                 AD 3 Temporal Ctx 
                 37.4 
                 33.4 
               
               
                   
                 AD 4 Temporal Ctx 
                 50.3 
                 66.4 
               
               
                   
                 AD 5 Inf Temporal Ctx 
                 23.0 
                 26.4 
               
               
                   
                 AD 5 Sup Temporal Ctx 
                 42.3 
                 43.8 
               
               
                   
                 AD 6 Inf Temporal Ctx 
                 88.3 
                 100.0 
               
               
                   
                 AD 6 Sup Temporal Ctx 
                 70.2 
                 88.3 
               
               
                   
                 Control 1 Temporal Ctx 
                 16.6 
                 16.3 
               
               
                   
                 Control 2 Temporal Ctx 
                 16.7 
                 21.6 
               
               
                   
                 Control 3 Temporal Ctx 
                 7.2 
                 12.9 
               
               
                   
                 Control 3 Temporal Ctx 
                 19.8 
                 43.5 
               
               
                   
                 Control (Path) 1 Temporal Ctx 
                 20.6 
                 24.1 
               
               
                   
                 Control (Path) 2 Temporal Ctx 
                 20.6 
                 32.1 
               
               
                   
                 Control (Path) 3 Temporal Ctx 
                 14.0 
                 17.8 
               
               
                   
                 Control (Path) 4 Temporal Ctx 
                 20.9 
                 23.3 
               
               
                   
                 AD 1 Occipital Ctx 
                 31.9 
                 35.4 
               
               
                   
                 AD 2 Occipital Ctx (Missing) 
                 5.2 
                 4.8 
               
               
                   
                 AD 3 Occipital Ctx 
                 16.7 
                 23.5 
               
               
                   
                 AD 4 Occipital Ctx 
                 39.5 
                 46.3 
               
               
                   
                 AD 5 Occipital Ctx 
                 24.7 
                 22.8 
               
               
                   
                 AD 6 Occipital Ctx 
                 59.9 
                 87.7 
               
               
                   
                 Control 1 Occipital Ctx 
                 19.8 
                 14.9 
               
               
                   
                 Control 2 Occipital Ctx 
                 26.2 
                 29.9 
               
               
                   
                 Control 3 Occipital Ctx 
                 15.2 
                 15.7 
               
               
                   
                 Control 4 Occipital Ctx 
                 34.2 
                 36.6 
               
               
                   
                 Control (Path) 1 Occipital Ctx 
                 25.5 
                 24.1 
               
               
                   
                 Control (Path) 2 Occipital Ctx 
                 15.1 
                 20.3 
               
               
                   
                 Control (Path) 3 Occipital Ctx 
                 9.5 
                 14.2 
               
               
                   
                 Control (Path) 4 Occipital Ctx 
                 30.6 
                 37.6 
               
               
                   
                 Control 1 Parietal Ctx 
                 13.3 
                 14.0 
               
               
                   
                 Control 2 Parietal Ctx 
                 46.3 
                 57.8 
               
               
                   
                 Control 3 Parietal Ctx 
                 10.1 
                 12.9 
               
               
                   
                 Control (Path) 1 Parietal Ctx 
                 24.5 
                 29.5 
               
               
                   
                 Control (Path) 2 Parietal Ctx 
                 28.3 
                 35.6 
               
               
                   
                 Control (Path) 3 Parietal Ctx 
                 12.7 
                 18.9 
               
               
                   
                 Control (Path) 4 Parietal Ctx 
                 28.3 
                 32.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2505, Run 208123723    
               
               
                   
                   Column B - Rel. Exp. (%) Ag2505, Run 224116291    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 1.8 
               
               
                   
                 Pancreas 
                 13.7 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 1.5 
               
               
                   
                 Adrenal gland 
                 3.6 
               
               
                   
                 Thyroid 
                 100.0 
               
               
                   
                 Salivary gland 
                 4.1 
               
               
                   
                 Pituitary gland 
                 37.6 
               
               
                   
                 Brain (fetal) 
                 44.1 
               
               
                   
                 Brain (whole) 
                 9.3 
               
               
                   
                 Brain (amygdala) 
                 8.1 
               
               
                   
                 Brain (cerebellum) 
                 1.8 
               
               
                   
                 Brain (hippocampus) 
                 10.2 
               
               
                   
                 Brain (substantia nigra) 
                 29.3 
               
               
                   
                 Brain (thalamus) 
                 3.6 
               
               
                   
                 Cerebral Cortex 
                 7.7 
               
               
                   
                 Spinal cord 
                 15.2 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.0 
               
               
                   
                 astrocytoma SW1783 
                 0.3 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.4 
               
               
                   
                 astrocytoma SF-539 
                 1.8 
               
               
                   
                 astrocytoma SNB-75 
                 2.7 
               
               
                   
                 glioma SNB-19 
                 0.0 
               
               
                   
                 glioma U251 
                 9.3 
               
               
                   
                 glioma SF-295 
                 0.4 
               
               
                   
                 Heart (fetal) 
                 10.0 
               
               
                   
                 Heart 
                 3.1 
               
               
                   
                 Skeletal muscle (fetal) 
                 12.8 
               
               
                   
                 Skeletal muscle 
                 20.9 
               
               
                   
                 Bone marrow 
                 1.2 
               
               
                   
                 Thymus 
                 6.0 
               
               
                   
                 Spleen 
                 6.7 
               
               
                   
                 Lymph node 
                 6.7 
               
               
                   
                 Colorectal 
                 23.5 
               
               
                   
                 Stomach 
                 12.0 
               
               
                   
                 Small intestine 
                 54.3 
               
               
                   
                 Colon ca. SW480 
                 1.1 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 1.4 
               
               
                   
                 Colon ca. HT29 
                 7.3 
               
               
                   
                 Colon ca. HCT-116 
                 7.3 
               
               
                   
                 Colon ca. CaCo-2 
                 10.7 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 8.5 
               
               
                   
                 Colon ca. HCC-2998 
                 2.9 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 71.7 
               
               
                   
                 Bladder 
                 14.8 
               
               
                   
                 Trachea 
                 21.9 
               
               
                   
                 Kidney 
                 38.2 
               
               
                   
                 Kidney (fetal) 
                 27.5 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.2 
               
               
                   
                 Renal ca. RXF 393 
                 39.8 
               
               
                   
                 Renal ca. ACHN 
                 51.1 
               
               
                   
                 Renal ca. UO-31 
                 0.2 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Liver 
                 1.4 
               
               
                   
                 Liver (fetal) 
                 2.3 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 11.8 
               
               
                   
                 Lung 
                 75.3 
               
               
                   
                 Lung (fetal) 
                 54.7 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 5.5 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 5.6 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.2 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 1.2 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 1.2 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 3.2 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 1.8 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 14.6 
               
               
                   
                 Mammary gland 
                 11.9 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 89.5 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 24.7 
               
               
                   
                 Breast ca. BT-549 
                 2.3 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Ovary 
                 3.5 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 6.4 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.2 
               
               
                   
                 Ovarian ca. IGROV-1 
                 14.5 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 9.3 
               
               
                   
                 Uterus 
                 27.7 
               
               
                   
                 Placenta 
                 2.9 
               
               
                   
                 Prostate 
                 25.0 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 0.0 
               
               
                   
                 Testis 
                 2.5 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
               
               
                   
                 Melanoma M14 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
               
               
                   
                 Adipose 
                 19.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2505, Run 165531061    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.2 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.3 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.2 
               
               
                   
                 Primary Tr1 act 
                 0.1 
               
               
                   
                 Primary Th1 rest 
                 0.1 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.1 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.0 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.1 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.2 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.1 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.1 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.3 
               
               
                   
                 HUVEC IL-1beta 
                 0.2 
               
               
                   
                 HUVEC IFN gamma 
                 0.1 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.1 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1 beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.2 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 2.0 
               
               
                   
                 Small airway epithelium none 
                 0.5 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 19.6 
               
               
                   
                 Coronery artery SMC rest 
                 0.0 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Astrocytes rest 
                 2.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 2.0 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.4 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 1.3 
               
               
                   
                 Liver cirrhosis 
                 7.5 
               
               
                   
                 Lupus kidney 
                 13.3 
               
               
                   
                 NCI-H292 none 
                 21.8 
               
               
                   
                 NCI-H292 IL-4 
                 42.0 
               
               
                   
                 NCI-H292 IL-9 
                 41.8 
               
               
                   
                 NCI-H292 IL-13 
                 20.9 
               
               
                   
                 NCI-H292 IFN gamma 
                 14.4 
               
               
                   
                 HPAEC none 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.5 
               
               
                   
                 Lung fibroblast none 
                 4.5 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.3 
               
               
                   
                 Lung fibroblast IL-4 
                 14.6 
               
               
                   
                 Lung fibroblast IL-9 
                 3.9 
               
               
                   
                 Lung fibroblast IL-13 
                 8.7 
               
               
                   
                 Lung fibroblast IFN gamma 
                 14.9 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 0.2 
               
               
                   
                 IBD Colitis 2 
                 0.3 
               
               
                   
                 IBD Crohn&#39;s 
                 9.9 
               
               
                   
                 Colon 
                 41.2 
               
               
                   
                 Lung 
                 61.6 
               
               
                   
                 Thymus 
                 100.0 
               
               
                   
                 Kidney 
                 21.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2505, Run 164318134    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 5 Islet 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 97457_Patient-02go_adipose 
                 32.3 
               
               
                   
                 97476_Patient-07sk_skeletal muscle 
                 8.2 
               
               
                   
                 97477_Patient-07ut_uterus 
                 31.4 
               
               
                   
                 97478_Patient-07pl_placenta 
                 3.5 
               
               
                   
                 99167_Bayer Patient 1 
                 9.5 
               
               
                   
                 97482_Patient-08ut_uterus 
                 90.1 
               
               
                   
                 97483_Patient-08pl_placenta 
                 7.4 
               
               
                   
                 97486_Patient-09sk_skeletal muscle 
                 1.4 
               
               
                   
                 97487_Patient-09ut_uterus 
                 78.5 
               
               
                   
                 97488_Patient-09pl_placenta 
                 0.6 
               
               
                   
                 97492_Patient-10ut_uterus 
                 66.0 
               
               
                   
                 97493_Patient-10pl_placenta 
                 3.1 
               
               
                   
                 97495_Patient-11go_adipose 
                 28.3 
               
               
                   
                 97496_Patient-11sk_skeletal muscle 
                 5.8 
               
               
                   
                 97497_Patient-11ut_uterus 
                 35.4 
               
               
                   
                 97498_Patient-11pl_placenta 
                 2.0 
               
               
                   
                 97500_Patient-12go_adipose 
                 35.1 
               
               
                   
                 97501_Patient-12sk_skeletal muscle 
                 9.9 
               
               
                   
                 97502_Patient-12ut_uterus 
                 100.0 
               
               
                   
                 97503_Patient-12pl_placenta 
                 4.1 
               
               
                   
                 94721_Donor 2 U - A_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94722_Donor 2 U - B_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94723_Donor 2 U - C_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94709_Donor 2 AM - A_adipose 
                 0.0 
               
               
                   
                 94710_Donor 2 AM - B_adipose 
                 0.0 
               
               
                   
                 94711_Donor 2 AM - C_adipose 
                 0.0 
               
               
                   
                 94712_Donor 2 AD - A_adipose 
                 0.0 
               
               
                   
                 94713_Donor 2 AD - B_adipose 
                 0.0 
               
               
                   
                 94714_Donor 2 AD - C_adipose 
                 0.0 
               
               
                   
                 94742_Donor 3 U - A_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94743_Donor 3 U - B_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94730_Donor 3 AM - A_adipose 
                 0.0 
               
               
                   
                 94731_Donor 3 AM - B_adipose 
                 0.0 
               
               
                   
                 94732_Donor 3 AM - C_adipose 
                 0.2 
               
               
                   
                 94733_Donor 3 AD - A_adipose 
                 0.0 
               
               
                   
                 94734_Donor 3 AD - B_adipose 
                 0.0 
               
               
                   
                 94735_Donor 3 AD - C_adipose 
                 0.0 
               
               
                   
                 77138_Liver_HepG2untreated 
                 21.2 
               
               
                   
                 73556_Heart_Cardiac stromal cells (primary) 
                 0.0 
               
               
                   
                 81735_Small Intestine 
                 36.9 
               
               
                   
                 72409_Kidney_Proximal Convoluted Tubule 
                 4.6 
               
               
                   
                 82685_Small intestine_Duodenum 
                 27.0 
               
               
                   
                 90650_Adrenal_Adrenocortical adenoma 
                 0.3 
               
               
                   
                 72410_Kidney_HRCE 
                 7.2 
               
               
                   
                 72411_Kidney_HRE 
                 10.7 
               
               
                   
                 73139_Uterus_Uterine smooth muscle cells 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2505, Run 248045752    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AG 
               
             
            
               
                   
               
               
                   
               
               
                 general oncology screening panel_v_2.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Colon cancer 1 
                 7.7 
               
               
                   
                 Colon NAT 1 
                 2.5 
               
               
                   
                 Colon cancer 2 
                 26.4 
               
               
                   
                 Colon NAT 2 
                 8.4 
               
               
                   
                 Colon cancer 3 
                 38.2 
               
               
                   
                 Colon NAT 3 
                 16.7 
               
               
                   
                 Colon malignant cancer 4 
                 69.7 
               
               
                   
                 Colon NAT 4 
                 8.7 
               
               
                   
                 Lung cancer 1 
                 7.2 
               
               
                   
                 Lung NAT 1 
                 8.0 
               
               
                   
                 Lung cancer 2 
                 26.1 
               
               
                   
                 Lung NAT 2 
                 17.4 
               
               
                   
                 Squamous cell carcinoma 3 
                 19.6 
               
               
                   
                 Lung NAT 3 
                 8.3 
               
               
                   
                 Metastatic melanoma 1 
                 14.5 
               
               
                   
                 Melanoma 2 
                 1.1 
               
               
                   
                 Melanoma 3 
                 2.5 
               
               
                   
                 Metastatic melanoma 4 
                 13.5 
               
               
                   
                 Metastatic melanoma 5 
                 12.6 
               
               
                   
                 Bladder cancer 1 
                 1.0 
               
               
                   
                 Bladder NAT 1 
                 0.0 
               
               
                   
                 Bladder cancer 2 
                 2.4 
               
               
                   
                 Bladder NAT 2 
                 0.3 
               
               
                   
                 Bladder NAT 3 
                 0.7 
               
               
                   
                 Bladder NAT 4 
                 1.5 
               
               
                   
                 Prostate adenocarcinoma 1 
                 100.0 
               
               
                   
                 Prostate adenocarcinoma 2 
                 12.9 
               
               
                   
                 Prostate adenocarcinoma 3 
                 15.1 
               
               
                   
                 Prostate adenocarcinoma 4 
                 15.9 
               
               
                   
                 Prostate NAT 5 
                 14.7 
               
               
                   
                 Prostate adenocarcinoma 6 
                 13.1 
               
               
                   
                 Prostate adenocarcinoma 7 
                 16.2 
               
               
                   
                 Prostate adenocarcinoma 8 
                 4.5 
               
               
                   
                 Prostate adenocarcinoma 9 
                 33.4 
               
               
                   
                 Prostate NAT 10 
                 7.7 
               
               
                   
                 Kidney cancer 1 
                 9.6 
               
               
                   
                 Kidney NAT 1 
                 33.4 
               
               
                   
                 Kidney cancer 2 
                 19.8 
               
               
                   
                 Kidney NAT 2 
                 64.6 
               
               
                   
                 Kidney cancer 3 
                 7.1 
               
               
                   
                 Kidney NAT 3 
                 29.7 
               
               
                   
                 Kidney cancer 4 
                 8.5 
               
               
                   
                 Kidney NAT 4 
                 7.9 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2505, Run 267145080    
               
            
           
         
       
     
      AI_comprehensive panel_v1.0 Summary: Ag2505 Highest expression of this gene was seen in a sample derived from rheumatoid arthritis bone (CT=27). This gene displayed ubiquitous expression, but expression of this gene was higher in bone, synovium, cartilage and synovial fluid from RA patients as compared to expression in samples from OA patients, normal and diseased lung samples. Expression of this gene was downregulated in Crohn&#39;s samples as compared to the corresponding control samples. This gene encodes a putative novel adhesion molecule which is homologous to mouse POEM (preosteoblast epidermal growth factor-like repeat protein with meprin)or nephronectin. Murine nephronectin may function in multiple biological processes including development of the kidney (Miner J H. J Cell Biol 2001 Jul 23; 154(2):257-9) and bone and contribute to liver and lung fibrosis (Levine et al., 2000, Am J Pathol 2000 June; 156(6):1927-35). Therapeutic modulation of this gene or gene product is useful in the treatment of autoimmune and inflammatory diseases such as rheumatoid and osteoarthritis, Inflammatory bowel disease, COPD, asthma, psoriasis, liver and lung fibrosis.  
      CNS_neurodegeneration_v1.0 Summary: Ag2505 Greater expression of this gene in the temporal cortex of Alzheimer&#39;s disease patients demonstrates a functional role for this gene, an EGF homolog, in neurodegenerative disease. Alpha secretase activity, which is generally believed to be a beneficial processing alternative to beta secretase, is increased by EGF in neuronal cells. (Slack B E. C.Biochem J 1997 October 1;327 ( Pt 1):245-9) This suggests the increased expression observed here is a compensatory action in the brain to counter the mechanisms of Alzheimer&#39;s Disease. This gene or the protein encoded by this gene is a potential therapeutic agent for the treatment of Alzheimer&#39;s disease and other neurodegenerative diseases.  
      EGF is also known to facilitate long term potentiation (LTP) in the hippocampus, a process thought to underlie learning and memory. (Abe K Brain Res 1992 Octobter 16;593(2):335-8 ) This gene has utility in treating disorders of memory, such as neurodegenerative diseases and aging, when used alone or incombination with other growth factors such as bFGF.  
      In addition, EGF supports the growth and differentiation of dopaniinergic neurons, which are selectively vulnerable to loss in Parkinson&#39;s disease. (Storch A. Exp Neurol 2001 August; 170(2):317-25 ). This gene or gene product has utility in treating Parkinson&#39;s Disease.  
      Panel 1.3D Summary: Ag2505 Highest expression of this gene was detected in the thyroid (CT=29.3), with lower but still significant levels of expression seen in other metabolic tissues, including skeletal muscle, fetal skeletal muscle, small intestine, stomach, pancreas, adipose and fetal heart. Very low levels were also seen in heart and placenta. This gene encodes a putative novel adhesion molecule. Studies in mouse have revealed a gene (perhaps the mouse ortholog of this human gene) very homologous to this gene that is called POEM (preosteoblast epidermal growth factor-like repeat protein with meprin, A5 protein, and receptor protein-tyrosine phosphatase mu domain; Morimura N et al., J Biol Chem 2001 November 9;276(45):42172-81) or nephronectin (Brandenberger R et al., J Cell Biol 2001 July 23;154(2):447-58). POEM/nephronectin seems to be a ligand for the alpha8betal integrin as evidenced by two independent sets of published data. Integrins are known to mediate development and organogenesis. (Schwartz et al., Annu. Rev. Cell Dev. Biol. 11, 549-599, 1995; Clark and Brugge, Science 268, 233-239, 1995)Other known ligands for the alpha8beta1 integrin include fibronectin, vitronectin, tenascin, and osteopontin. Modulation of the expression or activity of this gene or gene product by protein, small molecule, or antibody therapeutics is an effective therapeutic for disorders involving alpha8beta1 integrin signaling.  
      Overall, this gene is expressed at a low to moderate level in the normal tissues on this panel. The brain, prostate, lung and colon cancer cell lines show a very low level of expression compared to the normal organs. This molecule is a candidate as a therapeutic inhibitor for these cancers.  
      Expression in the brain in the substantia nigra, hippocampus, cortex, amygdala, thalamus and spinal cord indicates a further functional role for this gene product in CNS processes mediated by these regions. Please see CNS_neurodegeneration_v1.0 for discussion of utility in the central nervous system.  
      Panel 4D Summary: Ag 2505 Highest expression of this transcript was found in the thymus and the lung (CTs=27-28). Consistent with this lung expression, this transcript was found in the pulmonary mucoepidermoid cell line H292 and was up-regulated upon treatment with the Th2 cytokines IL4 and IL9. This gene was also expressed at lower levels in lung fibroblasts treated with IL4. Modulation of the expression or activity of this gene or gene product by small molecule, protein or antibody therapeutics is beneficial for the treatment of inflammatory lung diseases such as asthma, emphysema and chronic obstructive pulmonary diseases. Therapeutics designed with the gene or the protein encoded for by this transcript are important for maintaining or restoring normal function of thymus during inflammation.  
      Panel 5 Islet Summary: Ag2505 Highest expression of this gene was detected in uterus (CT=30). Moderate expression of this gene was also seen in adipose and skeletal muscle of gestational diabetic patients both requiring and not requiring daily injections of insulin. This gene was also expressed in samples derived from a pregnant and a nondiabetic, but overweight patient. In addition, this gene was also expressed in islet beta cells (those that are insulin producing) and small intestine. Therefore, therapeutic modulation of this gene or gene product is useful in the treatment of metabolically related diseases including obesity, Type I and Type II diabetes.  
      general oncology screening panel_v — 2.4 Summary: Ag2505 Highest expression of this gene was detected in prostate cancer (CT=27.7). Moderate to low levels of expression of this gene was seen in both normal and cancer samples derived from colon, lung, prostate and kidney. Consistent with panels 2.2 and 2D, expression of this gene was downregulated in kidney cancer as compared to normal kidney. But higher expression of this gene was seen in colon cancer as compared to corresponding normal adjacent sample. Therefore, expression of this gene distinguishes between cancer and normal kidney and colon tissue. Please see panel 1.3, 1.6, 2.2 for further discussion on the utility of this gene.  
      B. CG50377-01 and CG50377-02 and CG50377-03 and CG50377-04 and CG50377-05 and CG50377-06: (Cub-Sushi)x Domain Containing Protein  
      Expression of gene CG50377-01 and variants CG50377-02, CG50377-03, CG50377-04, CG50377-05 and CG50377-06 was assessed using the primer-probe sets Ag2420 and Ag5824, described in Tables BA and BB. Results of the RTQ-PCR runs are shown in Tables BC, BD, BE and BF.  
                   TABLE BA                          Probe Name Ag2420                                                     Start   SEQ ID           Primers   Sequences   Length   Position   No                                             Forward   5′-ctgcacttggctggaactta-3′   20   9465   1216                   Probe   TET-5′-tttcatctcctactccaggtgtacca-3′-   26   9498   1217           TAMRA               Reverse   5′-atctccacaggccctgtaat-3′   20   9525   1218                  
 
     
       
         
           
               
             
               
                 TABLE BB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag5824 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-ccgcttcatctctgatttctc-3′ 
                 21 
                 2319 
                 1219 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-tgaaggattcaacatcaccttctcag-3′- 
                 26 
                 2349 
                 1220 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-acagggctccaagtcgtact-3′ 
                 20 
                 2375 
                 1221 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BC 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.5 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 0.0 
               
               
                   
                 Melanoma* Hs688(A).T 
                 6.7 
               
               
                   
                 Melanoma* Hs688(B).T 
                 4.6 
               
               
                   
                 Melanoma* M14 
                 0.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.0 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.3 
               
               
                   
                 Testis Pool 
                 0.5 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate Pool 
                 0.1 
               
               
                   
                 Placenta 
                 0.0 
               
               
                   
                 Uterus Pool 
                 0.1 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.2 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.8 
               
               
                   
                 Ovary 
                 0.1 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca. BT 549 
                 0.0 
               
               
                   
                 Breast ca. T47D 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Breast Pool 
                 0.2 
               
               
                   
                 Trachea 
                 0.3 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Fetal Lung 
                 0.0 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.0 
               
               
                   
                 Lung ca. A549 
                 0.0 
               
               
                   
                 Lung ca. NCI-H526 
                 0.5 
               
               
                   
                 Lung ca. NCI-H23 
                 0.3 
               
               
                   
                 Lung ca. NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. HOP-62 
                 0.1 
               
               
                   
                 Lung ca. NCI-H522 
                 0.8 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 0.1 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
               
               
                   
                 Kidney Pool 
                 0.1 
               
               
                   
                 Fetal Kidney 
                 0.9 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Bladder 
                 1.6 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.0 
               
               
                   
                 Gastric ca. KATO III 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.2 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.1 
               
               
                   
                 Colon cancer tissue 
                 1.0 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 0.1 
               
               
                   
                 Small Intestine Pool 
                 0.6 
               
               
                   
                 Stomach Pool 
                 0.3 
               
               
                   
                 Bone Marrow Pool 
                 0.1 
               
               
                   
                 Fetal Heart 
                 0.1 
               
               
                   
                 Heart Pool 
                 0.1 
               
               
                   
                 Lymph Node Pool 
                 0.2 
               
               
                   
                 Fetal Skeletal Muscle 
                 0.3 
               
               
                   
                 Skeletal Muscle Pool 
                 0.1 
               
               
                   
                 Spleen Pool 
                 0.7 
               
               
                   
                 Thymus Pool 
                 0.5 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 100.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 4.6 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.0 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 1.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.6 
               
               
                   
                 CNS cancer (glio) SF-295 
                 19.6 
               
               
                   
                 Brain (Amygdala) Pool 
                 4.0 
               
               
                   
                 Brain (cerebellum) 
                 9.5 
               
               
                   
                 Brain (fetal) 
                 86.5 
               
               
                   
                 Brain (Hippocampus) Pool 
                 5.4 
               
               
                   
                 Cerebral Cortex Pool 
                 5.8 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 4.9 
               
               
                   
                 Brain (Thalamus) Pool 
                 7.7 
               
               
                   
                 Brain (whole) 
                 7.5 
               
               
                   
                 Spinal Cord Pool 
                 3.3 
               
               
                   
                 Adrenal Gland 
                 1.4 
               
               
                   
                 Pituitary gland Pool 
                 0.2 
               
               
                   
                 Salivary Gland 
                 0.0 
               
               
                   
                 Thyroid (female) 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.0 
               
               
                   
                 Pancreas Pool 
                 0.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag5824, Run 246273272    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 0.0 
               
               
                   
                 Pancreas 
                 0.9 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
               
               
                   
                 Adrenal gland 
                 1.1 
               
               
                   
                 Thyroid 
                 0.2 
               
               
                   
                 Salivary gland 
                 0.0 
               
               
                   
                 Pituitary gland 
                 0.4 
               
               
                   
                 Brain (fetal) 
                 100.0 
               
               
                   
                 Brain (whole) 
                 13.6 
               
               
                   
                 Brain (amygdala) 
                 27.4 
               
               
                   
                 Brain (cerebellum) 
                 3.9 
               
               
                   
                 Brain (hippocampus) 
                 95.3 
               
               
                   
                 Brain (substantia nigra) 
                 5.0 
               
               
                   
                 Brain (thalamus) 
                 7.9 
               
               
                   
                 Cerebral Cortex 
                 37.6 
               
               
                   
                 Spinal cord 
                 2.5 
               
               
                   
                 glio/astro U87-MG 
                 50.3 
               
               
                   
                 glio/astro U-118-MG 
                 2.7 
               
               
                   
                 astrocytoma SW1783 
                 10.9 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.0 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 0.0 
               
               
                   
                 glioma SNB-19 
                 0.8 
               
               
                   
                 glioma U251 
                 1.4 
               
               
                   
                 glioma SF-295 
                 7.8 
               
               
                   
                 Heart (fetal) 
                 0.0 
               
               
                   
                 Heart 
                 0.2 
               
               
                   
                 Skeletal muscle (fetal) 
                 1.3 
               
               
                   
                 Skeletal muscle 
                 0.0 
               
               
                   
                 Bone marrow 
                 0.0 
               
               
                   
                 Thymus 
                 0.0 
               
               
                   
                 Spleen 
                 1.2 
               
               
                   
                 Lymph node 
                 0.2 
               
               
                   
                 Colorectal 
                 0.0 
               
               
                   
                 Stomach 
                 0.2 
               
               
                   
                 Small intestine 
                 1.7 
               
               
                   
                 Colon ca. SW480 
                 0.3 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 1.1 
               
               
                   
                 Colon ca. HCC-2998 
                 0.0 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.0 
               
               
                   
                 Bladder 
                 0.6 
               
               
                   
                 Trachea 
                 0.2 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                 Kidney (fetal) 
                 0.6 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.2 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Liver (fetal) 
                 0.2 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
               
               
                   
                 Lung 
                 0.6 
               
               
                   
                 Lung (fetal) 
                 0.2 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.0 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.2 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
               
               
                   
                 Mammary gland 
                 0.4 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 1.3 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Ovary 
                 0.5 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.0 
               
               
                   
                 Uterus 
                 0.0 
               
               
                   
                 Placenta 
                 0.2 
               
               
                   
                 Prostate 
                 0.4 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 0.0 
               
               
                   
                 Testis 
                 1.3 
               
               
                   
                 Melanoma Hs688(A).T 
                 2.4 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.3 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
               
               
                   
                 Melanoma M14 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
               
               
                   
                 Adipose 
                 0.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2420, Run 159253002    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 10.7 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.0 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.0 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.7 
               
               
                   
                 Small airway epithelium none 
                 1.3 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Coronery artery SMC rest 
                 2.4 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 4.5 
               
               
                   
                 Astrocytes rest 
                 15.7 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 20.6 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 3.6 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 3.9 
               
               
                   
                 Liver cirrhosis 
                 1.6 
               
               
                   
                 NCI-H292 none 
                 0.0 
               
               
                   
                 NCI-H292 IL-4 
                 0.0 
               
               
                   
                 NCI-H292 IL-9 
                 0.0 
               
               
                   
                 NCI-H292 IL-13 
                 0.0 
               
               
                   
                 NCI-H292 IFN gamma 
                 0.0 
               
               
                   
                 HPAEC none 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 75.8 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 5.4 
               
               
                   
                 Lung fibroblast IL-4 
                 28.9 
               
               
                   
                 Lung fibroblast IL-9 
                 100.0 
               
               
                   
                 Lung fibroblast IL-13 
                 2.9 
               
               
                   
                 Lung fibroblast IFN gamma 
                 45.7 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 52.1 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 39.0 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 47.3 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 4.6 
               
               
                   
                 Dermal fibroblast IL-4 
                 11.8 
               
               
                   
                 Dermal Fibroblasts rest 
                 26.4 
               
               
                   
                 Neutrophils TNFa + LPS 
                 0.0 
               
               
                   
                 Neutrophils rest 
                 0.0 
               
               
                   
                 Colon 
                 0.0 
               
               
                   
                 Lung 
                 0.8 
               
               
                   
                 Thymus 
                 0.0 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag5824, Run 246921321    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 11.3 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.0 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.0 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
               
               
                   
                 Small airway epithelium none 
                 1.0 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Coronery artery SMC rest 
                 3.9 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1 beta 
                 3.2 
               
               
                   
                 Astrocytes rest 
                 100.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 32.8 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Liver cirrhosis 
                 0.0 
               
               
                   
                 Lupus kidney 
                 0.0 
               
               
                   
                 NCI-H292 none 
                 0.0 
               
               
                   
                 NCI-H292 IL-4 
                 0.0 
               
               
                   
                 NCI-H292 IL-9 
                 0.0 
               
               
                   
                 NCI-H292 IL-13 
                 0.0 
               
               
                   
                 NCI-H292 IFN gamma 
                 0.0 
               
               
                   
                 HPAEC none 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 36.3 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 4.6 
               
               
                   
                 Lung fibroblast IL-4 
                 52.9 
               
               
                   
                 Lung fibroblast IL-9 
                 78.5 
               
               
                   
                 Lung fibroblast IL-13 
                 37.4 
               
               
                   
                 Lung fibroblast IFN gamma 
                 37.6 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 63.3 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 27.0 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 20.3 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 8.6 
               
               
                   
                 Dermal fibroblast IL-4 
                 4.2 
               
               
                   
                 IBD Colitis 2 
                 0.0 
               
               
                   
                 IBD Crohn&#39;s 
                 0.0 
               
               
                   
                 Colon 
                 0.7 
               
               
                   
                 Lung 
                 0.8 
               
               
                   
                 Thymus 
                 1.9 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2420, Run 159255381    
               
            
           
         
       
     
      General_screeningpanel_v1.5 Summary: Ag5824 Highest expression of this gene was detected in a brain cancer cell line (CT=28.2). Significant expression of this gene was also seen in two melanoma and three brain cancer cell lines. Therefore, expression of this gene detects the presence of melanoma and brain cancer. Therapeutic modulation of this gene or its protein product is useful in the treatment of these cancers.  
      In addition, this gene was moderately expressed in all the regions of central nervous system examined, including amygdala, hippocampus, substantia nigra, thalamus, cerebellum, cerebral cortex, and spinal cord. Therapeutic modulation of this gene or gene product is useful in the treatment of central nervous system disorders such as Alzheimer&#39;s disease, Parkinson&#39;s disease, epilepsy, multiple sclerosis, schizophrenia and depression.  
      Panel 1.1 Summary: Ag575 Expression of this gene was restricted to normal brain derived tissue. In addition, expression was associated with a number of samples derived from brain cancer cell lines, with highest expression seen in the brain cancer cell line U87-MG (CT=23.5). Thus, the expression of this gene distinguishes these brain derived tissues from other samples in the panel. Therapeutic modulation of this gene or gene product, through the use of antibodies, small molecule drugs or protein therapeutics is of benefit in the treatment of brain cancer.  
      This gene also had moderate levels of expression in a number of metabolic tissues including adrenal, pituitary, heart, and fetal skeletal muscle.  
      Panel 1.3D Summary: Ag2420 Expression of this gene was restricted to normal brain derived tissue, with highest expression seen in the fetal brain (CT=29.8). In addition, expression was associated with a number of samples derived from brain cancer cell lines. Thus, the expression of this gene distinguishes these brain derived tissues from other samples in the panel. Therapeutic modulation of this gene or gene product, through the use of antibodies, small molecule drugs or protein therapeutics is of benefit in the treatment of brain cancer.  
      This gene represents a novel protein containing CUB and sushi domains. Its expression profile was highly brain-preferential; levels in the CNS appear 10-fold greater than in other tissues. At least one brain-specific protein containing CUB and sushi domains has been linked to seizures, and shows differential expression in response to pentylentetrazole (Shimizu-Nishikawa K, Brain Res Mol Brain Res 1995 February; 28(2):201-10). This gene or its protein product is a drug target for the treatment of epilepsy or any seizure disorder.  
      Panel 4.1D Summary: Ag5824 Highest expression of this gene was detected in IL-9 activated lung fibroblast cells (CT=32). Significant expression of this gene was also seen in resting and activated astrocytes, lung fibroblasts and dermal fibroblasts. The expression pattern in this panel was in agreement with that seen in panel 4D. Please see panel 4D for further discussion on the utility of this gene.  
      Panel 4D Summary: Ag2420 This gene encodes a cub-domain and sushi-domain containing single-pass membrane protein. Highest expression of this gene was seen in resting astrocytes (CT=30.6). Significant expression of this gene was also detected in TNF-alpha+IL-1-beta-stimulated astrocytes, resting and cytokine-stimulated lung fibroblasts and dermal fibroblasts. Therefore, an isolated extracellular domain of this gene or its protein product is useful as a therapeutic protein to reduce or eliminate the symptoms of multiple sclerosis, chronic obstructive pulmonary disease, asthma, or emphysema, and psoriasis.  
      Agonist or antagonist antibodies that stimulate or inhibit the function of this gene or its protein product are useful as therapeutics to reduce or eliminate the symptoms of multiple sclerosis, chronic obstructive pulmonary disease, asthma, or emphysema, and psoriasis.  
      C. CG5038904: Interleukin-1 Receptor Related Protein Like  
      Expression of gene CG50389-04 was assessed using the primer-probe set Ag48 11, described in Table CA. Results of the RTQ-PCR runs are shown in Tables CB and CC.  
               TABLE CA                          Probe Name Ag4811                                                 Start   SEQ ID           Primers   Sequences   Length   Position   No                                             Forward   5′-catgtctcttttcgggaacata-3′   22   918   1222                   Probe   TET-5′-cacagtaaacatcaccttcttggaagtg-3′-   28   947   1223           TAMRA       Reverse   5′-gaaggccataatcttccatttt-3′   22   975   1224                  
 
     
       
         
           
               
             
               
                 TABLE CB 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 4.9 
               
               
                   
                 Melanoma* Hs688(A).T 
                 1.4 
               
               
                   
                 Melanoma* Hs688(B).T 
                 2.9 
               
               
                   
                 Melanoma* M14 
                 0.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.0 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 45.4 
               
               
                   
                 Testis Pool 
                 1.7 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate Pool 
                 2.7 
               
               
                   
                 Placenta 
                 0.5 
               
               
                   
                 Uterus Pool 
                 0.4 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 1.4 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.3 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 45.1 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.4 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 25.9 
               
               
                   
                 Ovary 
                 6.0 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 32.1 
               
               
                   
                 Breast ca. BT 549 
                 10.9 
               
               
                   
                 Breast ca. T47D 
                 1.2 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Breast Pool 
                 6.3 
               
               
                   
                 Trachea 
                 8.1 
               
               
                   
                 Lung 
                 0.1 
               
               
                   
                 Fetal Lung 
                 5.3 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 3.9 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.0 
               
               
                   
                 Lung ca. A549 
                 0.1 
               
               
                   
                 Lung ca. NCI-H526 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 3.8 
               
               
                   
                 Lung ca. NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. HOP-62 
                 0.1 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
               
               
                   
                 Liver 
                 1.2 
               
               
                   
                 Fetal Liver 
                 4.3 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
               
               
                   
                 Kidney Pool 
                 3.2 
               
               
                   
                 Fetal Kidney 
                 5.1 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 5.3 
               
               
                   
                 Renal ca. TK-10 
                 71.7 
               
               
                   
                 Bladder 
                 6.5 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 100.0 
               
               
                   
                 Gastric ca. KATO III 
                 24.1 
               
               
                   
                 Colon ca. SW-948 
                 2.4 
               
               
                   
                 Colon ca. SW480 
                 7.1 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.5 
               
               
                   
                 Colon ca. HT29 
                 16.8 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.5 
               
               
                   
                 Colon cancer tissue 
                 12.1 
               
               
                   
                 Colon ca. SW1116 
                 6.9 
               
               
                   
                 Colon ca. Colo-205 
                 3.7 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 1.6 
               
               
                   
                 Small Intestine Pool 
                 1.2 
               
               
                   
                 Stomach Pool 
                 7.0 
               
               
                   
                 Bone Marrow Pool 
                 3.1 
               
               
                   
                 Fetal Heart 
                 0.4 
               
               
                   
                 Heart Pool 
                 1.3 
               
               
                   
                 Lymph Node Pool 
                 2.8 
               
               
                   
                 Fetal Skeletal Muscle 
                 0.6 
               
               
                   
                 Skeletal Muscle Pool 
                 3.0 
               
               
                   
                 Spleen Pool 
                 4.2 
               
               
                   
                 Thymus Pool 
                 3.8 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.2 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 0.8 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.3 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.4 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 4.9 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.0 
               
               
                   
                 Brain (Amygdala) Pool 
                 4.6 
               
               
                   
                 Brain (cerebellum) 
                 0.4 
               
               
                   
                 Brain (fetal) 
                 4.7 
               
               
                   
                 Brain (Hippocampus) Pool 
                 3.0 
               
               
                   
                 Cerebral Cortex Pool 
                 6.9 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 4.9 
               
               
                   
                 Brain (Thalamus) Pool 
                 9.2 
               
               
                   
                 Brain (whole) 
                 7.0 
               
               
                   
                 Spinal Cord Pool 
                 0.8 
               
               
                   
                 Adrenal Gland 
                 12.5 
               
               
                   
                 Pituitary gland Pool 
                 0.1 
               
               
                   
                 Salivary Gland 
                 2.8 
               
               
                   
                 Thyroid (female) 
                 6.3 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.0 
               
               
                   
                 Pancreas Pool 
                 21.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag4811, Run 223204488    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE CC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 1.5 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.9 
               
               
                   
                 Primary Th2 act 
                 5.1 
               
               
                   
                 Primary Tr1 act 
                 2.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 3.3 
               
               
                   
                 CD8 lymphocyte act 
                 0.7 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 2.9 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.7 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 3.9 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 1.2 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.7 
               
               
                   
                 LAK cells PMA/ionomycin 
                 11.1 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.7 
               
               
                   
                 Two Way MLR 7 day 
                 1.6 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 4.8 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 10.7 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.8 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 2.7 
               
               
                   
                 Dendritic cells none 
                 9.4 
               
               
                   
                 Dendritic cells LPS 
                 0.6 
               
               
                   
                 Dendritic cells anti-CD40 
                 15.5 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 8.8 
               
               
                   
                 Macrophages rest 
                 1.6 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.0 
               
               
                   
                 HUVEC IL-1beta 
                 1.7 
               
               
                   
                 HUVEC IFN gamma 
                 2.3 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 8.5 
               
               
                   
                 Small airway epithelium none 
                 11.1 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 14.9 
               
               
                   
                 Coronery artery SMC rest 
                 3.1 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 1.4 
               
               
                   
                 Astrocytes rest 
                 2.2 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 100.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 89.5 
               
               
                   
                 Liver cirrhosis 
                 4.6 
               
               
                   
                 NCI-H292 none 
                 2.4 
               
               
                   
                 NCI-H292 IL-4 
                 5.0 
               
               
                   
                 NCI-H292 IL-9 
                 1.9 
               
               
                   
                 NCI-H292 IL-13 
                 6.0 
               
               
                   
                 NCI-H292 IFN gamma 
                 3.9 
               
               
                   
                 HPAEC none 
                 2.4 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 26.1 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 17.1 
               
               
                   
                 Lung fibroblast IL-4 
                 33.9 
               
               
                   
                 Lung fibroblast IL-9 
                 27.7 
               
               
                   
                 Lung fibroblast IL-13 
                 25.9 
               
               
                   
                 Lung fibroblast IFN gamma 
                 52.1 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 9.8 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 5.4 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 4.3 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 5.6 
               
               
                   
                 Dermal fibroblast IL-4 
                 14.9 
               
               
                   
                 Dermal Fibroblasts rest 
                 7.5 
               
               
                   
                 Neutrophils TNFa + LPS 
                 54.7 
               
               
                   
                 Neutrophils rest 
                 0.9 
               
               
                   
                 Colon 
                 0.8 
               
               
                   
                 Lung 
                 4.4 
               
               
                   
                 Thymus 
                 4.5 
               
               
                   
                 Kidney 
                 29.9 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag4811, Run 223273603    
               
            
           
         
       
     
      General_screeningpanel_v1.4 Summary: Ag4811 The highest expression of this gene was detected in a sample derived from a gastric cancer cell line (NCI-N87) (CT=29.2). There was low to moderate expression associated with other gastric cancer cell lines, colon cancer cell lines, breast cancer cell lines, ovarian cancer cell lines and a renal cancer cell line. The expression of this gene or protein product is useful as a marker for gastric cancer, colon cancer, breast cancer, ovarian cancer or renal cancer. Therapeutic modulation of this gene or its protein product through the use of antibodies, protein therapeutics or small molecule drugs is useful in the treatment of gastric cancer, colon cancer, breast cancer, ovarian cancer or renal cancer.  
      This gene was also moderately expressed in a number of metabolic tissues including adipose, fetal liver, skeletal muscle, adrenal, thyroid and pancreas. Therapeutic modulation of this gene, expressed protein and/or use of antibodies, protein therapeutics or small molecule drugs targeting the gene or gene product are useful in the treatment of metabolic diseases, including obesity and Types 1 and 2 diabetes.  
      This gene product was expressed at low levels in the brain. This gene encodes a protein with homology to an interleukin 1 receptor-like protein. Interleukins are involved in many brain pathologies due to the pro-inflammatory action of interleukins. Inflammation is a key pathological process mediating the damage seen in many disease states including stroke, Alzheimer&#39;s disease, and spinocerebellar ataxias (J Neurosci 2001 August 1;21(15):5389-96). IL-1 receptor like protein has been shown to bind IL-18 (J Immunol 1999 May 1;162(9):5041-4), which is involved in CNS inflammation. Moreover, anti-inflammatory agents that are associated with reduced risk of Alzheimer&#39;s Disease, such as NSAIDS (Drug Saf 2001;24(11):801-11), have been shown to inhibit IL-18 expression. Therapeutic modulation of this gene, expressed protein and/or use of antibodies or small molecule drugs targeting the gene or gene product are useful in the treatment of stroke, Alzheimer&#39;s disease, and spinocerebellar ataxias and any other CNS disorder in which inflammation plays a role.  
      Panel 4.1D Summary: Ag 4811 The highest expression of this gene was detected in keratinocytes, regardless of their treatment. This transcript encodes a novel IL-1 receptor related protein that may have the potential to trigger novel members of the IL-1 family members as described by Debets et. al. (J Immunol 2001 August 1;167(3):1440-6; J Biol Chem 1996 February 23;271(8):3967-70). Novel IL1 receptor like molecules have been cloned and reported to lead to activation of NF-KB and IL18 production, a potent inflammatory cytokine associated with lung inflammation, IBD and psoriasis. IL1 R family members have also been shown to mediate inflammatory signals through NF-kB activation, among other signalling pathways. Therapeutic modulation of this gene, expressed protein and/or use of antibodies or small molecule drugs targeting the gene or gene product are useful in the treatment of inflammatory lung and skin diseases such as asthma, bronchitis, emphysema and psoriasis.  
      This gene was also expressed at moderate levels in neutrophils stimulated with TNF-a and LPS. The expression of this transcript in neutrophils demonstrates an important role of this receptor in innate immunity and in inflammation associated with neutrophil accummulation such as observed in inflammatory bowel diseases, psoriasis, asthma, chronic bronchitis and rheumatoid arthritis. Therapeutic modulation of this gene, expressed protein and/or use of antibodies or small molecule drugs targeting the gene or gene product are useful in the treatment of inflammatory disorders including inflammatory bowel diseases, psoriasis, asthma, chronic bronchitis and rheumatoid arthritis.  
      D. CG50389-06: Interleukin-1 Receptor Related Protein  
      Expression of full-length physical clone CG50389-06 was assessed using the primer-probe sets Ag4944 and Ag4945, described in Tables DA and DB. Results of the RTQ-PCR runs are shown in Table DC.  
               TABLE DA                          Probe Name Ag4944                                                 Start   SEQ ID           Primers   Sequences   Length   Position   No                                             Forward   5′-cagggaagcagtacgaggttt-3′   21   1161   1225                   Probe   TET-5′-tggaggaagtgtccctaaaatcatttatcc-   30   1091   1226           3′-TAMRA               Reverse   5′-tgactctccagcatcgtaga-3′   20   990   1227                  
 
     
       
         
           
               
               
             
               
                 TABLE DB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag4945 
                   
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Positon 
                 No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-cagtgagataccacatgccg-3′ 
                 20 
                 175 
                 1228 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-agctgccgcagcacacaccttgctac- 
                 26 
                 118 
                 1229 
               
               
                   
                 3′-TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-gtcatcttccagccataggtgt-3′ 
                 22 
                 22 
                 1230 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE DC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Secondary Th1 act 
                 0.0 
                 52.1 
               
               
                 Secondary Th2 act 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 act 
                 0.0 
                 0.0 
               
               
                 Secondary Th1 rest 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 rest 
                 0.0 
                 32.3 
               
               
                 Secondary Tr1 rest 
                 0.0 
                 64.2 
               
               
                 Primary Th1 act 
                 0.0 
                 12.9 
               
               
                 Primary Th2 act 
                 0.0 
                 18.3 
               
               
                 Primary Tr1 act 
                 0.0 
                 0.0 
               
               
                 Primary Th1 rest 
                 0.0 
                 0.0 
               
               
                 Primary Th2 rest 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 rest 
                 0.0 
                 17.1 
               
               
                 CD45RA CD4 lymphocyte act 
                 0.0 
                 34.2 
               
               
                 CD45RO CD4 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD8 lymphocyte act 
                 0.0 
                 50.7 
               
               
                 Secondary CD8 lymphocyte rest 
                 0.0 
                 20.2 
               
               
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD4 lymphocyte none 
                 0.0 
                 0.0 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
                 12.9 
               
               
                 LAK cells rest 
                 0.0 
                 20.0 
               
               
                 LAK cells IL-2 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-12 
                 0.0 
                 43.5 
               
               
                 LAK cells IL-2 + IFN gamma 
                 0.0 
                 21.6 
               
               
                 LAK cells IL-2 + IL-18 
                 0.0 
                 49.0 
               
               
                 LAK cells PMA/ionomycin 
                 7.7 
                 40.3 
               
               
                 NK Cells IL-2 rest 
                 0.0 
                 61.1 
               
               
                 Two Way MLR 3 day 
                 0.0 
                 12.4 
               
               
                 Two Way MLR 5 day 
                 0.0 
                 11.8 
               
               
                 Two Way MLR 7 day 
                 0.0 
                 0.0 
               
               
                 PBMC rest 
                 0.0 
                 21.3 
               
               
                 PBMC PWM 
                 0.0 
                 48.0 
               
               
                 PBMC PHA-L 
                 0.0 
                 25.3 
               
               
                 Ramos (B cell) none 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) ionomycin 
                 0.0 
                 16.6 
               
               
                 B lymphocytes PWM 
                 10.0 
                 35.1 
               
               
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 30.4 
               
               
                 Dendritic cells none 
                 6.9 
                 0.0 
               
               
                 Dendritic cells LPS 
                 0.0 
                 40.3 
               
               
                 Dendritic cells anti-CD40 
                 6.2 
                 0.0 
               
               
                 Monocytes rest 
                 0.0 
                 47.6 
               
               
                 Monocytes LPS 
                 0.0 
                 0.0 
               
               
                 Macrophages rest 
                 0.0 
                 27.7 
               
               
                 Macrophages LPS 
                 0.0 
                 8.9 
               
               
                 HUVEC none 
                 0.0 
                 27.9 
               
               
                 HUVEC starved 
                 0.0 
                 17.3 
               
               
                 HUVEC IL-1beta 
                 0.0 
                 14.7 
               
               
                 HUVEC IFN gamma 
                 0.0 
                 17.2 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IL4 
                 0.0 
                 58.6 
               
               
                 HUVEC IL-11 
                 0.0 
                 35.1 
               
               
                 Lung Microvascular EC none 
                 0.0 
                 0.0 
               
               
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
                 37.9 
               
               
                 Microvascular Dermal EC none 
                 0.0 
                 19.9 
               
               
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Bronchial epithelium TNFalpha + IL1beta 
                 10.7 
                 10.1 
               
               
                 Small airway epithelium none 
                 2.7 
                 44.8 
               
               
                 Small airway epithelium TNFalpha + IL-1beta 
                 8.1 
                 33.4 
               
               
                 Coronery artery SMC rest 
                 0.0 
                 18.7 
               
               
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
                 34.9 
               
               
                 Astrocytes rest 
                 0.0 
                 18.6 
               
               
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
                 12.4 
               
               
                 KU-812 (Basophil) rest 
                 0.0 
                 18.9 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) none 
                 99.3 
                 68.8 
               
               
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 100.0 
                 21.6 
               
               
                 Liver cirrhosis 
                 0.0 
                 0.0 
               
               
                 NCI-H292 none 
                 5.7 
                 48.3 
               
               
                 NCI-H292 IL-4 
                 0.0 
                 19.9 
               
               
                 NCI-H292 IL-9 
                 3.1 
                 20.4 
               
               
                 NCI-H292 IL-13 
                 8.0 
                 0.0 
               
               
                 NCI-H292 IFN gamma 
                 3.2 
                 0.0 
               
               
                 HPAEC none 
                 0.0 
                 55.9 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
                 19.1 
               
               
                 Lung fibroblast none 
                 3.9 
                 74.7 
               
               
                 Lung fibroblast TNF alpha + IL-1 beta 
                 10.2 
                 48.3 
               
               
                 Lung fibroblast IL-4 
                 19.5 
                 44.8 
               
               
                 Lung fibroblast IL-9 
                 31.9 
                 56.6 
               
               
                 Lung fibroblast IL-13 
                 23.8 
                 0.0 
               
               
                 Lung fibroblast IFN gamma 
                 33.2 
                 37.9 
               
               
                 Dermal fibroblast CCD1070 rest 
                 0.0 
                 100.0 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 4.5 
                 24.8 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
                 23.2 
               
               
                 Dermal fibroblast IFN gamma 
                 0.0 
                 11.8 
               
               
                 Dermal fibroblast IL-4 
                 12.2 
                 46.0 
               
               
                 Dermal Fibroblasts rest 
                 3.8 
                 0.0 
               
               
                 Neutrophils TNFa + LPS 
                 23.5 
                 51.8 
               
               
                 Neutrophils rest 
                 2.5 
                 0.0 
               
               
                 Colon 
                 0.0 
                 0.0 
               
               
                 Lung 
                 0.0 
                 29.1 
               
               
                 Thymus 
                 0.0 
                 8.9 
               
               
                 Kidney 
                 15.3 
                 39.2 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag4944, Run 223598842    
               
               
                   Column B - Rel. Exp. (%) Ag4945, Run 223625870    
               
            
           
         
       
     
      Panel 4.1D Summary: 4845/4944 Highest expression of the CG50389-06 transcript was seen in keratinocytes, regardless of their treatment with TNF-a plus IL-1b.  
      It was also found to a lesser extent in neutrophils and lung fibroblasts. This transcript encodes for a novel IL-1 receptor related protein that may have the potential to trigger novel members of the IL-1 family members as described by Debets and Parnet. (J Immunol Aug. 1, 2001; 167(3):1440-6; J Biol Chem. Feb. 23, 1996; 271(8):3967-70 ). Novel IL1 receptor like molecules have been cloned and reported to lead to activation of NF-kB and IL18 production, a potent inflammatory cytokine associated with lung inflammation, IBD and psoriasis. IL1 R family members have also been shown to mediate inflammatory signals through NF-kB activation, among other signalling pathways. Modulation of the function of this receptor by the use of protein therapeutics or antibodies prevents or reduces the severity of inflammatory processes observed in inflammatory lung and skin diseases such as asthma, bronchitis, emphysema and psoriasis.  
      E. CG50391-08 and CG50391-09 and CG50391-01:  
      Expression of gene CG50391-08 was assessed using the primer-probe sets Ag2654, Ag2726, and Ag2826, described in Tables EA, EB, and EC. Results of the RTQ-PCR runs are shown in Tables ED, EE, EF and EG.  
               TABLE EA                          Probe Name Ag2654                                 Primer   Sequences   Length   Start Position   SEQ ID No                                             Forward   5′-tagaggagctgctcagcaaata-3′   22   297   1231                   Probe   TET-5′-cacaacgagtctcactcccgggt-3′-TAMRA   23   323   1232               Reverse   5′-catgaggatctcctccttgtc-3′   21   368   1233                  
 
     
       
         
           
               
             
               
                 TABLE EB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag2726 
               
            
           
           
               
               
               
               
               
            
               
                 Primers 
                 Sequences 
                 Length 
                 Start Position 
                 SEQ ID No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-tagaggagctgctcagcaaata-3′ 
                 22 
                 297 
                 1234 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-cacaacgagtctcactcccgggt-3′-TAMRA 
                 23 
                 323 
                 1235 
               
               
                   
               
               
                 Reverse 
                 5′-catgaggatctcctccttgtc-3′ 
                 21 
                 368 
                 1236 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE EC 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag2826 
               
            
           
           
               
               
               
               
               
            
               
                 Primers 
                 Sequences 
                 Length 
                 Start Position 
                 SEQ ID No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-ccctcttactctagcccatttg-3′ 
                 22 
                 2108 
                 1237 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-tgtctgaccagcaaacattaaaacca-3′-TAMRA 
                 26 
                 2080 
                 1238 
               
               
                   
               
               
                 Reverse 
                 5′-acagtccgtccctaccaataga-3′ 
                 22 
                 2052 
                 1239 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ED 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Liver adenocarcinoma 
                 5.9 
                 3.9 
                 4.5 
                   
               
               
                 Pancreas 
                 1.7 
                 1.5 
                 1.1 
               
               
                 Pancreatic ca. CAPAN 2 
                 0.1 
                 0.2 
                 0.2 
               
               
                 Adrenal gland 
                 10.4 
                 10.7 
                 10.5 
               
               
                 Thyroid 
                 6.3 
                 6.9 
                 5.6 
               
               
                 Salivary gland 
                 1.0 
                 2.5 
                 2.6 
               
               
                 Pituitary gland 
                 1.8 
                 1.8 
                 1.4 
               
               
                 Brain (fetal) 
                 0.2 
                 0.4 
                 0.3 
               
               
                 Brain (whole) 
                 1.6 
                 1.4 
                 0.9 
               
               
                 Brain (amygdala) 
                 1.6 
                 1.8 
                 1.7 
               
               
                 Brain (cerebellum) 
                 0.5 
                 0.8 
                 0.5 
               
               
                 Brain (hippocampus) 
                 6.2 
                 6.3 
                 5.0 
               
               
                 Brain (substantia nigra) 
                 1.5 
                 1.9 
                 0.5 
               
               
                 Brain (thalamus) 
                 1.4 
                 1.4 
                 2.0 
               
               
                 Cerebral Cortex 
                 0.9 
                 1.4 
                 1.6 
               
               
                 Spinal cord 
                 8.3 
                 6.0 
                 6.0 
               
               
                 glio/astro U87-MG 
                 0.0 
                 0.1 
                 0.0 
               
               
                 glio/astro U-118-MG 
                 4.0 
                 3.1 
                 2.5 
               
               
                 astrocytoma SW1783 
                 13.0 
                 12.6 
                 9.7 
               
               
                 neuro*; met SK-N-AS 
                 1.3 
                 1.3 
                 0.5 
               
               
                 astrocytoma SF-539 
                 0.4 
                 0.1 
                 0.7 
               
               
                 astrocytoma SNB-75 
                 5.7 
                 5.8 
                 4.2 
               
               
                 glioma SNB-19 
                 0.2 
                 0.0 
                 0.0 
               
               
                 glioma U251 
                 0.0 
                 0.1 
                 0.1 
               
               
                 glioma SF-295 
                 2.4 
                 2.4 
                 0.8 
               
               
                 Heart (fetal) 
                 17.4 
                 19.1 
                 9.7 
               
               
                 Heart 
                 5.7 
                 6.0 
                 4.9 
               
               
                 Skeletal muscle (fetal) 
                 100.0 
                 100.0 
                 100.0 
               
               
                 Skeletal muscle 
                 0.6 
                 0.4 
                 0.6 
               
               
                 Bone marrow 
                 5.0 
                 6.3 
                 5.1 
               
               
                 Thymus 
                 3.6 
                 2.8 
                 2.4 
               
               
                 Spleen 
                 8.8 
                 9.1 
                 11.3 
               
               
                 Lymph node 
                 4.7 
                 5.6 
                 3.8 
               
               
                 Colorectal 
                 27.9 
                 29.7 
                 44.4 
               
               
                 Stomach 
                 8.7 
                 12.9 
                 12.2 
               
               
                 Small intestine 
                 16.6 
                 8.7 
                 23.3 
               
               
                 Colon ca. SW480 
                 2.0 
                 2.5 
                 1.4 
               
               
                 Colon ca.* SW620(SW480 met) 
                 0.0 
                 0.1 
                 0.1 
               
               
                 Colon ca. HT29 
                 0.3 
                 0.0 
                 0.2 
               
               
                 Colon ca. HCT-116 
                 0.4 
                 0.7 
                 0.6 
               
               
                 Colon ca. CaCo-2 
                 0.2 
                 0.7 
                 0.4 
               
               
                 Colon ca. tissue(ODO3866) 
                 20.0 
                 24.7 
                 17.2 
               
               
                 Colon ca. HCC-2998 
                 0.3 
                 0.6 
                 0.7 
               
               
                 Gastric ca.* (liver met) NCI-N87 
                 0.3 
                 0.6 
                 1.4 
               
               
                 Bladder 
                 14.2 
                 17.8 
                 7.9 
               
               
                 Trachea 
                 13.6 
                 11.9 
                 7.6 
               
               
                 Kidney 
                 1.3 
                 1.6 
                 1.1 
               
               
                 Kidney (fetal) 
                 8.1 
                 9.0 
                 4.7 
               
               
                 Renal ca. 786-0 
                 2.4 
                 4.4 
                 2.4 
               
               
                 Renal ca. A498 
                 4.0 
                 7.2 
                 4.7 
               
               
                 Renal ca. RXF 393 
                 4.2 
                 6.3 
                 5.7 
               
               
                 Renal ca. ACHN 
                 79.0 
                 79.0 
                 38.7 
               
               
                 Renal ca. UO-31 
                 15.4 
                 17.0 
                 6.9 
               
               
                 Renal ca. TK-10 
                 0.3 
                 0.3 
                 0.1 
               
               
                 Liver 
                 1.1 
                 1.0 
                 0.7 
               
               
                 Liver (fetal) 
                 2.7 
                 5.3 
                 4.5 
               
               
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung 
                 25.0 
                 24.5 
                 27.4 
               
               
                 Lung (fetal) 
                 29.1 
                 26.1 
                 22.2 
               
               
                 Lung ca. (small cell) LX-1 
                 0.8 
                 0.0 
                 1.1 
               
               
                 Lung ca. (small cell) NCI-H69 
                 0.4 
                 0.0 
                 0.8 
               
               
                 Lung ca. (s. cell var.) SHP-77 
                 2.7 
                 4.6 
                 1.8 
               
               
                 Lung ca. (large cell) NCI-H460 
                 0.1 
                 0.0 
                 0.0 
               
               
                 Lung ca. (non-sm. cell) A549 
                 0.1 
                 0.2 
                 0.1 
               
               
                 Lung ca. (non-s. cell) NCI-H23 
                 0.4 
                 0.7 
                 0.4 
               
               
                 Lung ca. (non-s. cell) HOP-62 
                 0.8 
                 1.6 
                 0.5 
               
               
                 Lung ca. (non-s. cl) NCI-H522 
                 0.1 
                 0.2 
                 0.0 
               
               
                 Lung ca. (squam.) SW 900 
                 0.8 
                 1.3 
                 2.4 
               
               
                 Lung ca. (squam.) NCI-H596 
                 0.1 
                 0.0 
                 0.5 
               
               
                 Mammary gland 
                 16.7 
                 11.7 
                 10.8 
               
               
                 Breast ca.* (pl. ef) MCF-7 
                 0.9 
                 0.0 
                 0.1 
               
               
                 Breast ca.* (pl. ef) MDA-MB-231 
                 3.3 
                 5.2 
                 2.9 
               
               
                 Breast ca.* (pl. ef) T47D 
                 1.4 
                 0.5 
                 2.8 
               
               
                 Breast ca. BT-549 
                 2.6 
                 2.4 
                 2.3 
               
               
                 Breast ca. MDA-N 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ovary 
                 28.1 
                 28.3 
                 47.6 
               
               
                 Ovarian ca. OVCAR-3 
                 7.0 
                 7.6 
                 5.5 
               
               
                 Ovarian ca. OVCAR-4 
                 0.0 
                 0.4 
                 0.2 
               
               
                 Ovarian ca. OVCAR-5 
                 2.1 
                 1.4 
                 1.3 
               
               
                 Ovarian ca. OVCAR-8 
                 0.3 
                 0.4 
                 0.0 
               
               
                 Ovarian ca. IGROV-1 
                 0.1 
                 0.1 
                 0.0 
               
               
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.0 
                 0.1 
                 0.0 
               
               
                 Uterus 
                 26.2 
                 23.3 
                 22.4 
               
               
                 Placenta 
                 27.4 
                 29.1 
                 32.5 
               
               
                 Prostate 
                 29.5 
                 33.2 
                 38.2 
               
               
                 Prostate ca.* (bone met)PC-3 
                 0.1 
                 0.0 
                 0.1 
               
               
                 Testis 
                 13.4 
                 12.2 
                 10.5 
               
               
                 Melanoma Hs688(A).T 
                 47.0 
                 42.0 
                 20.7 
               
               
                 Melanoma* (met) Hs688(B).T 
                 3.6 
                 4.5 
                 4.2 
               
               
                 Melanoma UACC-62 
                 0.0 
                 0.1 
                 0.1 
               
               
                 Melanoma M14 
                 0.0 
                 0.1 
                 0.0 
               
               
                 Melanoma LOX IMVI 
                 2.3 
                 0.0 
                 0.0 
               
               
                 Melanoma* (met) SK-MEL-5 
                 0.1 
                 0.5 
                 0.0 
               
               
                 Adipose 
                 81.8 
                 77.9 
                 44.8 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag2654, Run 153009856    
               
               
                   Column B - Rel. Exp. (%) Ag2726, Run 153622446    
               
               
                   Column C - Rel. Exp. (%) Ag2826, Run 153774039    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE EE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
                 C 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Normal Colon 
                 52.1 
                 75.3 
                 58.2 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 18.7 
                 19.5 
                 15.2 
               
               
                   
                 CC Margin (ODO3866) 
                 18.4 
                 18.4 
                 13.2 
               
               
                   
                 CC Gr.2 rectosigmoid 
                 8.2 
                 10.4 
                 2.8 
               
               
                   
                 (ODO3868) 
               
               
                   
                 CC Margin (ODO3868) 
                 9.0 
                 8.2 
                 2.3 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 8.7 
                 9.2 
                 3.6 
               
               
                   
                 CC Margin (ODO3920) 
                 20.2 
                 20.9 
                 5.0 
               
               
                   
                 CC Gr.2 ascend colon 
                 16.4 
                 17.9 
                 15.9 
               
               
                   
                 (ODO3921) 
               
               
                   
                 CC Margin (ODO3921) 
                 16.4 
                 18.2 
                 11.0 
               
               
                   
                 CC from Partial Hepatectomy 
                 14.4 
                 11.7 
                 10.4 
               
               
                   
                 (ODO4309) Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 8.9 
                 6.0 
                 7.9 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 16.5 
                 12.2 
                 4.5 
               
               
                   
                 Lung Margin (OD04451-02) 
                 33.9 
                 28.3 
                 9.9 
               
               
                   
                 Normal Prostate 6546-1 
                 66.0 
                 45.1 
                 51.8 
               
               
                   
                 Prostate Cancer (OD04410) 
                 30.4 
                 30.1 
                 31.9 
               
               
                   
                 Prostate Margin (OD04410) 
                 75.8 
                 82.9 
                 67.8 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 58.2 
                 47.6 
                 31.0 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 51.1 
                 46.3 
                 31.0 
               
               
                   
                 Normal Lung 061010 
                 16.4 
                 17.9 
                 20.4 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 4.5 
                 2.8 
                 2.5 
               
               
                   
                 Muscle Margin (ODO4286) 
                 22.2 
                 20.7 
                 10.3 
               
               
                   
                 Lung Malignant Cancer 
                 10.4 
                 6.4 
                 9.4 
               
               
                   
                 (OD03126) 
               
               
                   
                 Lung Margin (OD03126) 
                 15.8 
                 16.0 
                 12.7 
               
               
                   
                 Lung Cancer (OD04404) 
                 16.6 
                 14.1 
                 11.8 
               
               
                   
                 Lung Margin (OD04404) 
                 87.7 
                 54.3 
                 40.1 
               
               
                   
                 Lung Cancer (OD04565) 
                 15.2 
                 14.5 
                 7.7 
               
               
                   
                 Lung Margin (OD04565) 
                 17.8 
                 13.8 
                 3.5 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 5.9 
                 7.2 
                 11.8 
               
               
                   
                 Lung Margin (OD04237-02) 
                 64.6 
                 48.3 
                 43.8 
               
               
                   
                 Ocular Mel Met to Liver 
                 0.4 
                 0.7 
                 0.6 
               
               
                   
                 (ODO4310) 
               
               
                   
                 Liver Margin (ODO4310) 
                 12.6 
                 10.6 
                 9.8 
               
               
                   
                 Melanoma Mets to Lung 
                 1.6 
                 1.1 
                 1.1 
               
               
                   
                 (OD04321) 
               
               
                   
                 Lung Margin (OD04321) 
                 32.8 
                 33.2 
                 32.8 
               
               
                   
                 Normal Kidney 
                 21.0 
                 17.6 
                 25.7 
               
               
                   
                 Kidney Ca, Nuclear grade 2 
                 33.7 
                 31.6 
                 22.4 
               
               
                   
                 (OD04338) 
               
               
                   
                 Kidney Margin (OD04338) 
                 48.0 
                 39.5 
                 14.4 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 
                 3.1 
                 3.1 
                 1.4 
               
               
                   
                 (OD04339) 
               
               
                   
                 Kidney Margin (OD04339) 
                 9.3 
                 7.6 
                 4.5 
               
               
                   
                 Kidney Ca, Clear cell type 
                 27.4 
                 23.7 
                 17.0 
               
               
                   
                 (OD04340) 
               
               
                   
                 Kidney Margin (OD04340) 
                 34.9 
                 28.3 
                 19.1 
               
               
                   
                 Kidney Ca, Nuclear grade 3 
                 9.3 
                 8.0 
                 5.3 
               
               
                   
                 (OD04348) 
               
               
                   
                 Kidney Margin (OD04348) 
                 27.0 
                 23.2 
                 10.9 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 12.7 
                 11.6 
                 6.9 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 8.4 
                 7.4 
                 4.5 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 10.6 
                 6.4 
                 8.5 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 29.7 
                 24.8 
                 8.2 
               
               
                   
                 Kidney Cancer 8120607 
                 3.6 
                 4.9 
                 2.5 
               
               
                   
                 Kidney Margin 8120608 
                 12.8 
                 16.5 
                 6.8 
               
               
                   
                 Kidney Cancer 8120613 
                 0.4 
                 0.0 
                 0.1 
               
               
                   
                 Kidney Margin 8120614 
                 9.9 
                 9.4 
                 5.4 
               
               
                   
                 Kidney Cancer 9010320 
                 35.4 
                 33.4 
                 18.7 
               
               
                   
                 Kidney Margin 9010321 
                 27.5 
                 24.8 
                 11.3 
               
               
                   
                 Normal Uterus 
                 20.4 
                 24.1 
                 12.9 
               
               
                   
                 Uterus Cancer 064011 
                 50.0 
                 48.6 
                 12.2 
               
               
                   
                 Normal Thyroid 
                 11.4 
                 7.2 
                 10.4 
               
               
                   
                 Thyroid Cancer 064010 
                 1.6 
                 2.1 
                 2.5 
               
               
                   
                 Thyroid Cancer A302152 
                 13.8 
                 12.5 
                 3.5 
               
               
                   
                 Thyroid Margin A302153 
                 9.0 
                 7.7 
                 9.9 
               
               
                   
                 Normal Breast 
                 33.2 
                 32.5 
                 14.9 
               
               
                   
                 Breast Cancer (OD04566) 
                 9.9 
                 8.5 
                 2.1 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 7.5 
                 9.9 
                 9.6 
               
               
                   
                 Breast Cancer Mets 
                 14.2 
                 14.7 
                 12.7 
               
               
                   
                 (OD04590-03) 
               
               
                   
                 Breast Cancer Metastasis 
                 2.5 
                 1.8 
                 2.0 
               
               
                   
                 (OD04655-05) 
               
               
                   
                 Breast Cancer 064006 
                 20.7 
                 19.8 
                 18.4 
               
               
                   
                 Breast Cancer 1024 
                 15.4 
                 16.2 
                 12.9 
               
               
                   
                 Breast Cancer 9100266 
                 12.0 
                 11.7 
                 18.2 
               
               
                   
                 Breast Margin 9100265 
                 15.2 
                 15.2 
                 21.8 
               
               
                   
                 Breast Cancer A209073 
                 10.7 
                 10.2 
                 12.8 
               
               
                   
                 Breast Margin A209073 
                 7.7 
                 11.1 
                 8.2 
               
               
                   
                 Normal Liver 
                 2.1 
                 2.0 
                 1.9 
               
               
                   
                 Liver Cancer 064003 
                 1.1 
                 1.0 
                 1.4 
               
               
                   
                 Liver Cancer 1025 
                 5.2 
                 5.3 
                 2.6 
               
               
                   
                 Liver Cancer 1026 
                 7.3 
                 7.6 
                 7.7 
               
               
                   
                 Liver Cancer 6004-T 
                 9.3 
                 11.6 
                 3.4 
               
               
                   
                 Liver Tissue 6004-N 
                 3.8 
                 3.8 
                 2.6 
               
               
                   
                 Liver Cancer 6005-T 
                 10.2 
                 10.7 
                 8.0 
               
               
                   
                 Liver Tissue 6005-N 
                 4.1 
                 3.9 
                 2.1 
               
               
                   
                 Normal Bladder 
                 37.1 
                 43.2 
                 35.1 
               
               
                   
                 Bladder Cancer 1023 
                 11.3 
                 9.2 
                 11.2 
               
               
                   
                 Bladder Cancer A302173 
                 4.4 
                 5.6 
                 10.2 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 28.1 
                 30.6 
                 27.2 
               
               
                   
                 Bladder Normal Adjacent 
                 100.0 
                 100.0 
                 78.5 
               
               
                   
                 (OD04718-03) 
               
               
                   
                 Normal Ovary 
                 10.4 
                 8.1 
                 10.2 
               
               
                   
                 Ovarian Cancer 064008 
                 92.7 
                 95.9 
                 100.0 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 1.9 
                 1.7 
                 1.4 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 71.2 
                 68.3 
                 32.8 
               
               
                   
                 Normal Stomach 
                 70.7 
                 69.7 
                 43.5 
               
               
                   
                 Gastric Cancer 9060358 
                 12.8 
                 16.5 
                 24.3 
               
               
                   
                 Stomach Margin 9060359 
                 23.7 
                 25.2 
                 21.2 
               
               
                   
                 Gastric Cancer 9060395 
                 25.2 
                 32.5 
                 32.5 
               
               
                   
                 Stomach Margin 9060394 
                 43.2 
                 49.0 
                 55.9 
               
               
                   
                 Gastric Cancer 9060397 
                 28.1 
                 26.4 
                 29.3 
               
               
                   
                 Stomach Margin 9060396 
                 8.7 
                 10.2 
                 9.2 
               
               
                   
                 Gastric Cancer 064005 
                 18.6 
                 26.4 
                 33.9 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2654, Run 153009865    
               
               
                   
                   Column B - Rel. Exp. (%) Ag2726, Run 153622484    
               
               
                   
                   Column C - Rel. Exp. (%) Ag2826, Run 153774078    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE EF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
                 C 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.3 
                 0.5 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.1 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.1 
                 0.1 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.1 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.1 
                 0.1 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.1 
                 0.2 
                 0.2 
               
               
                   
                 Primary Th2 rest 
                 0.0 
                 0.1 
                 0.1 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 24.7 
                 20.9 
                 15.3 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.2 
                 0.1 
                 0.1 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
                 0.1 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.3 
                 0.3 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.4 
                 0.1 
                 0.2 
               
               
                   
                 2ry Th1/Th2/Tr1 anti-CD95 CH11 
                 0.0 
                 0.2 
                 0.0 
               
               
                   
                 LAK cells rest 
                 1.4 
                 2.7 
                 2.0 
               
               
                   
                 LAK cells IL-2 
                 0.2 
                 0.2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.1 
                 0.3 
                 0.1 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.4 
                 0.3 
                 0.2 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.4 
                 0.0 
                 0.2 
               
               
                   
                 LAK cells PMA/ionomycin 
                 2.2 
                 1.0 
                 1.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
                 0.4 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 2.2 
                 3.6 
                 1.9 
               
               
                   
                 Two Way MLR 5 day 
                 0.8 
                 1.7 
                 0.8 
               
               
                   
                 Two Way MLR 7 day 
                 0.1 
                 0.4 
                 0.1 
               
               
                   
                 PBMC rest 
                 3.0 
                 3.6 
                 3.9 
               
               
                   
                 PBMC PWM 
                 3.8 
                 3.1 
                 4.1 
               
               
                   
                 PBMC PHA-L 
                 4.3 
                 3.6 
                 5.9 
               
               
                   
                 Ramos (B cell) none 
                 0.9 
                 1.2 
                 2.5 
               
               
                   
                 Ramos (B cell) ionomycin 
                 1.0 
                 1.1 
                 3.5 
               
               
                   
                 B lymphocytes PWM 
                 0.3 
                 0.5 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.6 
                 0.4 
                 0.1 
               
               
                   
                 EOL-1 dbcAMP 
                 0.2 
                 0.1 
                 0.1 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
                 0.1 
               
               
                   
                 Dendritic cells none 
                 0.2 
                 0.2 
                 0.2 
               
               
                   
                 Dendritic cells LPS 
                 0.4 
                 0.5 
                 0.3 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
                 0.1 
                 0.0 
               
               
                   
                 Monocytes rest 
                 31.0 
                 31.9 
                 33.4 
               
               
                   
                 Monocytes LPS 
                 1.4 
                 2.2 
                 1.3 
               
               
                   
                 Macrophages rest 
                 0.1 
                 0.7 
                 0.6 
               
               
                   
                 Macrophages LPS 
                 4.8 
                 6.3 
                 5.3 
               
               
                   
                 HUVEC none 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.3 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 0.1 
                 0.6 
                 0.1 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.2 
                 0.0 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung Microvascular EC 
                 0.0 
                 0.1 
                 0.0 
               
               
                   
                 TNFalpha + IL-1beta 
               
               
                   
                 Microvascular Dermal EC none 
                 1.4 
                 1.6 
                 1.1 
               
               
                   
                 Microsvasular Dermal EC 
                 0.1 
                 0.0 
                 0.1 
               
               
                   
                 TNFalpha + IL-1 beta 
               
               
                   
                 Bronchial epithelium TNFalpha + 
                 0.0 
                 0.0 
                 0.1 
               
               
                   
                 IL1beta 
               
               
                   
                 Small airway epithelium none 
                 1.6 
                 1.0 
                 1.6 
               
               
                   
                 Small airway epithelium 
                 2.2 
                 3.5 
                 6.4 
               
               
                   
                 TNFalpha + IL-1beta 
               
               
                   
                 Coronery artery SMC rest 
                 0.3 
                 0.3 
                 0.5 
               
               
                   
                 Coronery artery SMC TNFalpha + 
                 0.1 
                 0.4 
                 0.0 
               
               
                   
                 IL-1beta 
               
               
                   
                 Astrocytes rest 
                 18.9 
                 20.6 
                 21.2 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 9.0 
                 8.3 
                 11.6 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
                 0.1 
                 0.1 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.6 
                 0.0 
                 0.1 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.3 
                 0.4 
                 0.5 
               
               
                   
                 CCD1106 (Keratinocytes) 
                 0.0 
                 0.0 
                 0.1 
               
               
                   
                 TNFalpha + IL-1 beta 
               
               
                   
                 Liver cirrhosis 
                 18.3 
                 22.4 
                 12.5 
               
               
                   
                 Lupus kidney 
                 10.3 
                 9.6 
                 9.9 
               
               
                   
                 NCI-H292 none 
                 0.5 
                 0.3 
                 1.3 
               
               
                   
                 NCI-H292 IL-4 
                 0.7 
                 0.3 
                 1.4 
               
               
                   
                 NCI-H292 IL-9 
                 0.5 
                 0.7 
                 1.9 
               
               
                   
                 NCI-H292 IL-13 
                 0.6 
                 0.1 
                 0.7 
               
               
                   
                 NCI-H292 IFN gamma 
                 0.5 
                 0.4 
                 0.4 
               
               
                   
                 HPAEC none 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
                 0.4 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 12.0 
                 12.2 
                 10.4 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 
                 8.3 
                 9.7 
                 11.5 
               
               
                   
                 beta 
               
               
                   
                 Lung fibroblast IL-4 
                 17.8 
                 16.4 
                 25.0 
               
               
                   
                 Lung fibroblast IL-9 
                 16.3 
                 16.2 
                 16.8 
               
               
                   
                 Lung fibroblast IL-13 
                 14.2 
                 13.9 
                 13.9 
               
               
                   
                 Lung fibroblast IFN gamma 
                 29.9 
                 33.0 
                 40.9 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 89.5 
                 100.0 
                 100.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF 
                 63.3 
                 51.4 
                 76.8 
               
               
                   
                 alpha 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 
                 100.0 
                 94.0 
                 70.7 
               
               
                   
                 beta 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 9.7 
                 9.8 
                 7.9 
               
               
                   
                 Dermal fibroblast IL-4 
                 2.8 
                 1.6 
                 1.8 
               
               
                   
                 IBD Colitis 2 
                 22.8 
                 30.4 
                 22.4 
               
               
                   
                 IBD Crohn&#39;s 
                 11.2 
                 14.7 
                 10.4 
               
               
                   
                 Colon 
                 18.2 
                 22.1 
                 16.6 
               
               
                   
                 Lung 
                 51.8 
                 46.3 
                 40.6 
               
               
                   
                 Thymus 
                 11.2 
                 10.3 
                 11.9 
               
               
                   
                 Kidney 
                 10.6 
                 8.7 
                 8.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2654, Run 153594146    
               
               
                   
                   Column B - Rel. Exp. (%) Ag2726, Run 153622627    
               
               
                   
                   Column C - Rel. Exp. (%) Ag2826, Run 153774117    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE EG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 5D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 97457_Patient-02go_adipose 
                 100.0 
                 74.7 
               
               
                   
                 97476_Patient-07sk_skeletal muscle 
                 37.4 
                 31.9 
               
               
                   
                 97477_Patient-07ut_uterus 
                 83.5 
                 95.3 
               
               
                   
                 97478_Patient-07pl_placenta 
                 22.4 
                 22.5 
               
               
                   
                 97481_Patient-08sk_skeletal muscle 
                 12.2 
                 8.2 
               
               
                   
                 97482_Patient-08ut_uterus 
                 46.3 
                 48.6 
               
               
                   
                 97483_Patient-08pl_placenta 
                 19.5 
                 22.5 
               
               
                   
                 97486_Patient-09sk_skeletal muscle 
                 5.8 
                 7.5 
               
               
                   
                 97487_Patient-09ut_uterus 
                 19.9 
                 18.7 
               
               
                   
                 97488_Patient-09pl_placenta 
                 13.2 
                 24.8 
               
               
                   
                 97492_Patient-10ut_uterus 
                 29.7 
                 19.9 
               
               
                   
                 97493_Patient-10pl_placenta 
                 31.0 
                 30.4 
               
               
                   
                 97495_Patient-11go_adipose 
                 45.1 
                 31.4 
               
               
                   
                 97496_Patient-11sk_skeletal muscle 
                 11.0 
                 5.0 
               
               
                   
                 97497_Patient-11ut_uterus 
                 66.9 
                 57.0 
               
               
                   
                 97498_Patient-11pl_placenta 
                 11.5 
                 21.3 
               
               
                   
                 97500_Patient-12go_adipose 
                 62.0 
                 54.7 
               
               
                   
                 97501_Patient-12sk_skeletal muscle 
                 15.5 
                 25.9 
               
               
                   
                 97502_Patient-12ut_uterus 
                 90.1 
                 62.0 
               
               
                   
                 97503_Patient-12pl_placenta 
                 11.6 
                 11.6 
               
               
                   
                 94721_Donor 2 U- 
                 31.9 
                 10.9 
               
               
                   
                 A_Mesenchymal Stem Cells 
               
               
                   
                 94722_Donor 2 U - 
                 15.6 
                 16.6 
               
               
                   
                 B_Mesenchymal Stem Cells 
               
               
                   
                 94723_Donor 2 U - 
                 18.6 
                 25.3 
               
               
                   
                 C_Mesenchymal Stem Cells 
               
               
                   
                 94709_Donor 2 AM - A_adipose 
                 81.8 
                 100.0 
               
               
                   
                 94710_Donor 2 AM - B_adipose 
                 77.4 
                 84.1 
               
               
                   
                 94711_Donor 2 AM - C_adipose 
                 66.4 
                 33.9 
               
               
                   
                 94712_Donor 2 AD - A_adipose 
                 15.5 
                 14.8 
               
               
                   
                 94713_Donor 2 AD - B_adipose 
                 16.6 
                 18.8 
               
               
                   
                 94714_Donor 2 AD - C_adipose 
                 22.5 
                 22.5 
               
               
                   
                 94742_Donor 3 U - A_Mesenchymal 
                 33.9 
                 21.6 
               
               
                   
                 Stem Cells 
               
               
                   
                 94743_Donor 3 U - B_Mesenchymal 
                 27.0 
                 25.2 
               
               
                   
                 Stem Cells 
               
               
                   
                 94730_Donor 3 AM - A_adipose 
                 75.3 
                 65.1 
               
               
                   
                 94731_Donor 3 AM - B_adipose 
                 52.1 
                 80.1 
               
               
                   
                 94732_Donor 3 AM - C_adipose 
                 42.0 
                 35.6 
               
               
                   
                 94733_Donor 3 AD - A_adipose 
                 12.1 
                 9.9 
               
               
                   
                 94734_Donor 3 AD - B_adipose 
                 0.2 
                 14.5 
               
               
                   
                 94735_Donor 3 AD - C_adipose 
                 10.7 
                 13.0 
               
               
                   
                 77138_Liver_HepG2untreated 
                 1.3 
                 2.6 
               
               
                   
                 73556_Heart_Cardiac stromal cells 
                 0.2 
                 0.0 
               
               
                   
                 (primary) 
               
               
                   
                 81735_Small Intestine 
                 21.0 
                 27.2 
               
               
                   
                 72409_Kidney_Proximal Convoluted 
                 2.7 
                 2.8 
               
               
                   
                 Tubule 
               
               
                   
                 82685_Small intestine_Duodenum 
                 10.2 
                 13.1 
               
               
                   
                 90650_Adrenal_Adrenocortical 
                 11.0 
                 15.8 
               
               
                   
                 adenoma 
               
               
                   
                 72410_Kidney_HRCE 
                 25.2 
                 56.3 
               
               
                   
                 72411_Kidney_HRE 
                 7.6 
                 7.0 
               
               
                   
                 73139_Uterus_Uterine smooth muscle 
                 1.3 
                 3.1 
               
               
                   
                 cells 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2654, Run 169270118    
               
               
                   
                   Column B - Rel. Exp. (%) Ag2726, Run 169315037    
               
            
           
         
       
     
      Panel 1.3D Summary: Ag2654/Ag2726/Ag2826 Highest expression of this gene was detected in fetal skeletal muscle (CTs=27-28.2). This gene was expressed at much higher levels in fetal when compared to adult skeletal muscle (CT=35). The relative overexpression of this gene in fetal skeletal muscle demonstrates that the gene or protein product enhances muscular growth or development in the fetus and also acts in a regenerative capacity in the adult.  
      Moderate to low levels of expression of this gene were also seen in tissues with - metabolic/endocrine-functions-including pancreas,- adipose, adrenal gland, thyroid, pituitary gland, skeletal muscle, heart, liver and the gastrointestinal tract. -Therapeutic modulation of the activity of this gene or gene product is useful in the treatment of endocrine/metabolically related diseases, such as obesity and diabetes.  
      Moderate expression of this gene was also seen in number of cell lines derived from melanoma, liver, renal, breast, lung, ovarian, and brain cancers.  
      Panel 2D Summary: Ag2654/Ag2726/Ag2826 Highest expression of this gene was detected in a normal bladder sample (CTs=26-27.5). Significant expression of this gene was seen in both normal and cancer samples used in this panel. Expression of this gene was higher in normal lung, bladder and breast samples as compared to their corresponding cancer samples.  
      Panel 4D Summary: Ag2654/Ag2726/Ag2826 Highest expression of this gene was detected in dermal fibroblasts (CTs=26.4-28). High to moderate expression of this gene was detected in dermal and lung fibroblasts, activated CD45RA CD4 lymphocyte cells, two way MLR, PBMC cells, resting monocytes, LPS treated macrophage, small airway epithelium, liver cirrhosis, lupus kidney, IBD colon, and normal tissues represented by colon, lung, thymus and kidney.  
      Panel 5D Summary: Ag2654/Ag2726 Highest expression of this gene was seen in adipose (CTs=30). This gene showed ubiquitous expression in this panel, with moderate expression in adipose, skeletal muscle, small intesting, uterus, placenta, kidney, and mesenchmyal stem cells.  
      F. CG50426-15 and CG50426-17 and CG50426-21: NEURESTIN  
      Expression of full-length physical clone CG50426-15 and variants CG50426-17 and CG50426-21 was assessed using the primer-probe sets Ag2679, Ag2728, Ag2975, Ag332, Ag047, and Ag47b, described in Tables FA, FB, FC, FD, FE, and FF. Results of the RTQ-PCR runs are shown in Tables FG, FH, Fl and FJ. The CG50426-15 variant only corresponds to Ag332 and Ag47b.  
               TABLE FA                          Probe Name Ag2679                                 Primers   Sequences   Length   Start Position   SEQ ID No                                             Forward   5′-ttgacctcaggaacggtttac-3′   21   1136   1240                   Probe   TET-5′-ctgctgcccaggaatactttctccag-3′-TAMRA   26   1172   1241               Reverse   5′-agtatttggagggcttcttcag-3′   22   1211   1242                  
 
     
       
         
           
               
             
               
                 TABLE FB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag2728 
               
            
           
           
               
               
               
               
               
            
               
                 Primers 
                 Sequences 
                 Length 
                 Start Position 
                 SEQ ID No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-ggagcttggtctcatgaccta-3′ 
                 21 
                 4810 
                 1243 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-actgggctcctggccaccaagag-3′-TAMRA 
                 23 
                 4841 
                 1244 
               
               
                   
               
               
                 Reverse 
                 5′-agtcgtccatcctgtttcatc-3′ 
                 21 
                 4865 
                 1245 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE FC 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag2975 
               
            
           
           
               
               
               
               
               
            
               
                 Primers 
                 Sequences 
                 Length 
                 Start Position 
                 SEQ ID No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-ggagcttggtctcatgaccta-3′ 
                 21 
                 4810 
                 1246 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-actgggctcctggccaccaagag-3′-TAMRA 
                 23 
                 4841 
                 1247 
               
               
                   
               
               
                 Reverse 
                 5′-agtcgtccatcctgtttcatc-3′ 
                 21 
                 4865 
                 1248 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE FD 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag332 
               
            
           
           
               
               
               
               
               
            
               
                 Primers 
                 Sequences 
                 Length 
                 Start Position 
                 SEQ ID No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-gctgccctgacttgtgcaa-3′ 
                 19 
                 2211 
                 1249 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-tctgacccagtgtgcatctcccgtt-3′-TAMRA 
                 25 
                 2234 
                 1250 
               
               
                   
               
               
                 Reverse 
                 5′-ccggtctggcagacacact-3′ 
                 19 
                 2268 
                 1251 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE FE 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag047 
               
            
           
           
               
               
               
               
               
            
               
                 Primers 
                 Sequences 
                 Length 
                 Start Position 
                 SEQ ID No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-ccaatgacctggccacca-3′ 
                 18 
                 987 
                 1252 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ccagagtccgttcagcttcaggacagc-3′-TAMRA 
                 27 
                 1007 
                 1253 
               
               
                   
               
               
                 Reverse 
                 5′-gtggcacgttgctgtttagc-3′ 
                 20 
                 1039 
                 1254 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE FF 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag47b 
               
            
           
           
               
               
               
               
               
            
               
                 Primers 
                 Sequences 
                 Length 
                 Start Position 
                 SEQ ID No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-gaacgccggagcatacaga-3′ 
                 19 
                 1574 
                 1255 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ccaggtactgcacaaacacggcttcat-3′-TAMRA 
                 27 
                 1605 
                 1256 
               
               
                   
               
               
                 Reverse 
                 5′-gatgccacaggcccaca-3′ 
                 17 
                 1633 
                 1257 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE FG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1 
               
            
           
           
               
               
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
                 D 
                 E 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Endothelial cells 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Endothelial cells (treated) 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Pancreas 
                 0.0 
                 0.3 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Pancreatic ca. CAPAN 2 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Adrenal gland 
                 0.0 
                 1.3 
                 0.2 
                 0.0 
                 0.0 
               
               
                 Thyroid 
                 0.0 
                 0.4 
                 100.0 
                 0.1 
                 0.0 
               
               
                 Salivary gland 
                 0.0 
                 0.2 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Pituitary gland 
                 0.0 
                 0.1 
                 2.1 
                 0.0 
                 0.0 
               
               
                 Brain (fetal) 
                 0.0 
                 15.0 
                 3.4 
                 11.0 
                 21.8 
               
               
                 Brain (whole) 
                 95.9 
                 67.8 
                 3.2 
                 4.5 
                 32.5 
               
               
                 Brain (amygdala) 
                 0.0 
                 8.8 
                 3.8 
                 8.7 
                 12.2 
               
               
                 Brain (cerebellum) 
                 0.0 
                 22.2 
                 1.4 
                 0.1 
                 14.3 
               
               
                 Brain (hippocampus) 
                 0.0 
                 24.7 
                 3.4 
                 8.7 
                 15.6 
               
               
                 Brain (substantia nigra) 
                 3.4 
                 3.6 
                 1.3 
                 2.3 
                 3.8 
               
               
                 Brain (thalamus) 
                 3.5 
                 4.7 
                 3.3 
                 5.0 
                 9.1 
               
               
                 Brain (hypothalamus) 
                 0.0 
                 0.7 
                 0.2 
                 0.0 
                 0.0 
               
               
                 Spinal cord 
                 0.7 
                 1.5 
                 0.9 
                 1.4 
                 1.1 
               
               
                 glio/astro U87-MG 
                 0.6 
                 2.6 
                 1.6 
                 1.7 
                 3.0 
               
               
                 glio/astro U-118-MG 
                 0.0 
                 0.6 
                 0.2 
                 1.1 
                 0.1 
               
               
                 astrocytoma SW1783 
                 33.7 
                 29.5 
                 9.0 
                 42.9 
                 36.1 
               
               
                 neuro*; met SK-N-AS 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 astrocytoma SF-539 
                 31.0 
                 36.9 
                 10.3 
                 68.3 
                 48.3 
               
               
                 astrocytoma SNB-75 
                 33.7 
                 32.8 
                 7.1 
                 23.0 
                 50.3 
               
               
                 glioma SNB-19 
                 100.0 
                 100.0 
                 30.1 
                 100.0 
                 100.0 
               
               
                 glioma U251 
                 49.0 
                 44.1 
                 16.5 
                 57.8 
                 41.5 
               
               
                 glioma SF-295 
                 6.0 
                 8.1 
                 2.1 
                 19.8 
                 8.7 
               
               
                 Heart 
                 61.1 
                 26.8 
                 36.6 
                 70.7 
                 39.8 
               
               
                 Skeletal muscle 
                 0.0 
                 0.1 
                 0.2 
                 0.0 
                 0.0 
               
               
                 Bone marrow 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Thymus 
                 18.7 
                 18.4 
                 1.1 
                 2.7 
                 17.2 
               
               
                 Spleen 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lymph node 
                 0.0 
                 0.2 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Colon (ascending) 
                 0.5 
                 0.7 
                 0.7 
                 0.9 
                 4.5 
               
               
                 Stomach 
                 0.1 
                 1.1 
                 0.2 
                 0.2 
                 0.2 
               
               
                 Small intestine 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Colon ca. SW480 
                 0.6 
                 1.0 
                 1.6 
                 7.0 
                 1.4 
               
               
                 Colon ca.* SW620 (SW480 met) 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Colon ca. HT29 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Colon ca. HCT-116 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Colon ca. CaCo-2 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Colon ca. HCT-15 
                 0.0 
                 0.1 
                 0.2 
                 0.0 
                 0.0 
               
               
                 Colon ca. HCC-2998 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Gastric ca. * (liver met) NCI-N87 
                 0.0 
                 0.4 
                 0.2 
                 0.0 
                 0.0 
               
               
                 Bladder 
                 0.3 
                 1.0 
                 0.2 
                 0.0 
                 0.1 
               
               
                 Trachea 
                 0.0 
                 0.4 
                 0.2 
                 0.0 
                 0.0 
               
               
                 Kidney 
                 0.2 
                 0.9 
                 0.7 
                 1.2 
                 1.0 
               
               
                 Kidney (fetal) 
                 1.3 
                 3.9 
                 0.8 
                 3.2 
                 2.7 
               
               
                 Renal ca. 786-0 
                 10.6 
                 11.7 
                 3.4 
                 7.9 
                 12.2 
               
               
                 Renal ca. A498 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Renal ca. RXF 393 
                 17.9 
                 14.0 
                 4.1 
                 16.6 
                 15.2 
               
               
                 Renal ca. ACHN 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Renal ca. UO-31 
                 0.0 
                 0.2 
                 0.1 
                 0.0 
                 0.2 
               
               
                 Renal ca. TK-10 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Liver 
                 0.0 
                 3.2 
                 0.8 
                 0.9 
                 1.9 
               
               
                 Liver (fetal) 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung 
                 0.0 
                 0.2 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung (fetal) 
                 0.0 
                 0.5 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung ca. (small cell) LX-1 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung ca. (small cell) NCI-H69 
                 2.0 
                 3.3 
                 1.4 
                 5.4 
                 2.9 
               
               
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung ca. (large cell)NCI-H460 
                 0.0 
                 0.0 
                 1.3 
                 0.7 
                 0.3 
               
               
                 Lung ca. (non-sm. cell) A549 
                 0.0 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
               
               
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung ca. (non-s. cell) HOP-62 
                 5.2 
                 4.7 
                 3.9 
                 11.3 
                 6.7 
               
               
                 Lung ca. (non-s. cl) NCI-H522 
                 1.7 
                 3.1 
                 1.5 
                 2.8 
                 4.8 
               
               
                 Lung ca. (squam.) SW 900 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung ca. (squam.) NCI-H596 
                 1.3 
                 2.5 
                 2.0 
                 4.2 
                 3.0 
               
               
                 Mammary gland 
                 11.9 
                 9.1 
                 4.6 
                 7.0 
                 10.6 
               
               
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Breast ca.* (pl. ef) T47D 
                 11.8 
                 7.5 
                 7.9 
                 31.6 
                 31.4 
               
               
                 Breast ca. BT-549 
                 0.0 
                 0.0 
                 4.5 
                 13.8 
                 28.3 
               
               
                 Breast ca. MDA-N 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ovary 
                 0.1 
                 0.6 
                 0.4 
                 0.1 
                 0.2 
               
               
                 Ovarian ca. OVCAR-3 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ovarian ca. OVCAR-4 
                 0.0 
                 0.1 
                 1.3 
                 4.4 
                 0.0 
               
               
                 Ovarian ca. OVCAR-5 
                 73.2 
                 38.2 
                 14.4 
                 57.0 
                 36.1 
               
               
                 Ovarian ca. OVCAR-8 
                 0.0 
                 0.7 
                 1.0 
                 3.4 
                 0.2 
               
               
                 Ovarian ca. IGROV-1 
                 0.0 
                 0.0 
                 0.8 
                 2.6 
                 0.0 
               
               
                 Ovarian ca. (ascites) SK-OV-3 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Uterus 
                 0.4 
                 1.2 
                 0.6 
                 1.7 
                 2.9 
               
               
                 Placenta 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Prostate 
                 0.9 
                 1.9 
                 0.7 
                 1.9 
                 1.7 
               
               
                 Prostate ca.* (bone met) PC-3 
                 0.0 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
               
               
                 Testis 
                 25.7 
                 22.2 
                 0.7 
                 0.7 
                 26.4 
               
               
                 Melanoma Hs688(A).T 
                 23.8 
                 21.6 
                 5.0 
                 20.0 
                 28.9 
               
               
                 Melanoma* (met) Hs688(B).T 
                 4.6 
                 6.5 
                 3.4 
                 9.6 
                 9.2 
               
               
                 Melanoma UACC-62 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Melanoma M14 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Melanoma LOX IMVI 
                 3.7 
                 3.4 
                 0.6 
                 0.2 
                 2.7 
               
               
                 Melanoma* (met) SK-MEL-5 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Melanoma SK-MEL-28 
                 0.0 
                 0.0 
                 3.6 
                 17.4 
                 0.0 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag047, Run 87354354    
               
               
                   Column B - Rel. Exp. (%) Ag047, Run 87354779    
               
               
                   Column C - Rel. Exp. (%) Ag332, Run 97803603    
               
               
                   Column D - Rel. Exp. (%) Ag332, Run 98747043    
               
               
                   Column E - Rel. Exp. (%) Ag47b, Run 88164379    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE FH 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
                 D 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Normal Colon 
                 5.5 
                 8.9 
                 7.4 
                 10.4 
               
               
                 CC Well to Mod Diff (ODO3866) 
                 1.4 
                 0.2 
                 0.2 
                 1.3 
               
               
                 CC Margin (ODO3866) 
                 0.4 
                 0.5 
                 0.4 
                 0.1 
               
               
                 CC Gr.2 rectosigmoid (ODO3868) 
                 0.4 
                 0.1 
                 1.7 
                 0.2 
               
               
                 CC Margin (ODO3868) 
                 2.5 
                 0.9 
                 0.7 
                 0.7 
               
               
                 CC Mod Diff (ODO3920) 
                 0.0 
                 0.0 
                 0.0 
                 0.2 
               
               
                 CC Margin (ODO3920) 
                 0.7 
                 0.9 
                 1.1 
                 0.3 
               
               
                 CC Gr.2 ascend colon (ODO3921) 
                 0.0 
                 0.7 
                 0.6 
                 0.2 
               
               
                 CC Margin (ODO3921) 
                 0.2 
                 0.2 
                 0.6 
                 0.8 
               
               
                 CC from Partial Hepatectomy 
                 0.6 
                 0.4 
                 1.1 
                 1.0 
               
               
                 (ODO4309) Mets 
               
               
                 Liver Margin (ODO4309) 
                 11.1 
                 13.6 
                 30.4 
                 21.2 
               
               
                 Colon mets to lung (OD04451-01) 
                 0.0 
                 0.4 
                 0.1 
                 0.2 
               
               
                 Lung Margin (OD04451-02) 
                 1.3 
                 1.0 
                 0.5 
                 0.7 
               
               
                 Normal Prostate 6546-1 
                 19.1 
                 0.7 
                 1.0 
                 2.3 
               
               
                 Prostate Cancer (OD04410) 
                 5.8 
                 2.9 
                 4.7 
                 3.4 
               
               
                 Prostate Margin (OD04410) 
                 4.7 
                 5.7 
                 7.2 
                 4.9 
               
               
                 Prostate Cancer (OD04720-01) 
                 2.9 
                 3.3 
                 3.4 
                 3.3 
               
               
                 Prostate Margin (OD04720-02) 
                 12.5 
                 10.7 
                 8.3 
                 15.2 
               
               
                 Normal Lung 061010 
                 1.5 
                 2.7 
                 6.8 
                 5.4 
               
               
                 Lung Met to Muscle (ODO4286) 
                 0.3 
                 0.1 
                 0.0 
                 0.5 
               
               
                 Muscle Margin (ODO4286) 
                 0.3 
                 0.2 
                 0.3 
                 0.6 
               
               
                 Lung Malignant Cancer (OD03126) 
                 0.4 
                 0.2 
                 0.8 
                 1.5 
               
               
                 Lung Margin (OD03126) 
                 0.4 
                 1.0 
                 1.2 
                 0.5 
               
               
                 Lung Cancer (OD04404) 
                 86.5 
                 100.0 
                 100.0 
                 100.0 
               
               
                 Lung Margin (OD04404) 
                 18.3 
                 3.3 
                 2.2 
                 3.0 
               
               
                 Lung Cancer (OD04565) 
                 100.0 
                 52.1 
                 62.0 
                 77.9 
               
               
                 Lung Margin (OD04565) 
                 0.2 
                 0.1 
                 0.0 
                 0.6 
               
               
                 Lung Cancer (OD04237-01) 
                 6.3 
                 1.5 
                 3.2 
                 3.3 
               
               
                 Lung Margin (OD04237-02) 
                 1.4 
                 0.5 
                 0.5 
                 0.6 
               
               
                 Ocular Mel Met to Liver (ODO4310) 
                 0.4 
                 0.3 
                 0.5 
                 0.7 
               
               
                 Liver Margin (ODO4310) 
                 2.3 
                 1.8 
                 3.5 
                 2.8 
               
               
                 Melanoma Mets to Lung (OD04321) 
                 0.0 
                 0.3 
                 0.4 
                 1.6 
               
               
                 Lung Margin (OD04321) 
                 2.1 
                 2.6 
                 2.2 
                 3.0 
               
               
                 Normal Kidney 
                 6.7 
                 4.9 
                 8.4 
                 7.0 
               
               
                 Kidney Ca, Nuclear grade 2 
                 0.0 
                 0.0 
                 0.3 
                 1.4 
               
               
                 (OD04338) 
               
               
                 Kidney Margin (OD04338) 
                 3.5 
                 1.5 
                 4.1 
                 3.5 
               
               
                 Kidney Ca Nuclear grade 1/2 
                 0.0 
                 0.1 
                 0.3 
                 0.7 
               
               
                 (OD04339) 
               
               
                 Kidney Margin (OD04339) 
                 18.4 
                 10.3 
                 8.4 
                 15.5 
               
               
                 Kidney Ca, Clear cell type 
                 0.0 
                 0.8 
                 0.7 
                 1.1 
               
               
                 (OD04340) 
               
               
                 Kidney Margin (OD04340) 
                 6.5 
                 4.4 
                 4.5 
                 6.5 
               
               
                 Kidney Ca, Nuclear grade 3 
                 90.8 
                 36.1 
                 54.3 
                 50.3 
               
               
                 (OD04348) 
               
               
                 Kidney Margin (OD04348) 
                 4.6 
                 3.2 
                 3.8 
                 4.0 
               
               
                 Kidney Cancer (OD04622-01) 
                 2.7 
                 1.8 
                 4.1 
                 3.5 
               
               
                 Kidney Margin (OD04622-03) 
                 2.0 
                 0.2 
                 0.3 
                 1.1 
               
               
                 Kidney Cancer (OD04450-01) 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Kidney Margin (OD04450-03) 
                 3.1 
                 1.4 
                 6.9 
                 5.4 
               
               
                 Kidney Cancer 8120607 
                 1.5 
                 0.3 
                 0.5 
                 1.8 
               
               
                 Kidney Margin 8120608 
                 3.4 
                 0.8 
                 1.3 
                 2.2 
               
               
                 Kidney Cancer 8120613 
                 0.4 
                 0.8 
                 4.3 
                 2.0 
               
               
                 Kidney Margin 8120614 
                 2.8 
                 1.2 
                 4.9 
                 4.0 
               
               
                 Kidney Cancer 9010320 
                 76.8 
                 39.0 
                 36.3 
                 52.9 
               
               
                 Kidney Margin 9010321 
                 10.4 
                 5.1 
                 4.9 
                 4.3 
               
               
                 Normal Uterus 
                 0.0 
                 0.2 
                 0.3 
                 0.0 
               
               
                 Uterus Cancer 064011 
                 0.9 
                 0.0 
                 0.3 
                 1.9 
               
               
                 Normal Thyroid 
                 0.3 
                 0.0 
                 0.9 
                 2.2 
               
               
                 Thyroid Cancer 064010 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Thyroid Cancer A302152 
                 1.4 
                 0.1 
                 0.4 
                 0.0 
               
               
                 Thyroid Margin A302153 
                 1.7 
                 0.9 
                 6.4 
                 4.1 
               
               
                 Normal Breast 
                 20.3 
                 5.7 
                 13.0 
                 20.9 
               
               
                 Breast Cancer (OD04566) 
                 0.3 
                 0.1 
                 0.5 
                 0.3 
               
               
                 Breast Cancer (OD04590-01) 
                 2.4 
                 2.2 
                 1.1 
                 1.9 
               
               
                 Breast Cancer Mets (OD04590-03) 
                 0.7 
                 0.1 
                 0.3 
                 0.0 
               
               
                 Breast Cancer Metastasis 
                 6.9 
                 3.3 
                 7.7 
                 9.3 
               
               
                 (OD04655-05) 
               
               
                 Breast Cancer 064006 
                 5.6 
                 8.3 
                 4.2 
                 4.9 
               
               
                 Breast Cancer 1024 
                 47.0 
                 19.3 
                 30.1 
                 23.5 
               
               
                 Breast Cancer 9100266 
                 14.9 
                 9.3 
                 15.7 
                 21.8 
               
               
                 Breast Margin 9100265 
                 4.6 
                 1.5 
                 4.4 
                 8.4 
               
               
                 Breast Cancer A209073 
                 48.3 
                 12.9 
                 28.3 
                 40.9 
               
               
                 Breast Margin A209073 
                 38.7 
                 16.6 
                 27.5 
                 29.7 
               
               
                 Normal Liver 
                 0.2 
                 0.1 
                 0.0 
                 0.2 
               
               
                 Liver Cancer 064003 
                 11.8 
                 5.6 
                 4.6 
                 4.5 
               
               
                 Liver Cancer 1025 
                 4.5 
                 1.6 
                 4.2 
                 2.8 
               
               
                 Liver Cancer 1026 
                 6.2 
                 6.7 
                 9.0 
                 6.4 
               
               
                 Liver Cancer 6004-T 
                 15.6 
                 3.3 
                 3.5 
                 2.8 
               
               
                 Liver Tissue 6004-N 
                 0.1 
                 0.2 
                 0.2 
                 0.4 
               
               
                 Liver Cancer 6005-T 
                 14.6 
                 8.0 
                 8.7 
                 7.9 
               
               
                 Liver Tissue 6005-N 
                 6.4 
                 7.0 
                 5.9 
                 3.2 
               
               
                 Normal Bladder 
                 1.3 
                 0.9 
                 1.6 
                 0.9 
               
               
                 Bladder Cancer 1023 
                 0.4 
                 0.2 
                 0.3 
                 0.3 
               
               
                 Bladder Cancer A302173 
                 7.5 
                 5.3 
                 12.1 
                 19.8 
               
               
                 Bladder Cancer (OD04718-01) 
                 27.7 
                 23.0 
                 35.6 
                 41.5 
               
               
                 Bladder Normal Adjacent 
                 0.4 
                 0.3 
                 0.6 
                 0.7 
               
               
                 (OD04718-03) 
               
               
                 Normal Ovary 
                 1.4 
                 0.4 
                 1.1 
                 0.3 
               
               
                 Ovarian Cancer 064008 
                 1.3 
                 0.5 
                 1.3 
                 1.3 
               
               
                 Ovarian Cancer (OD04768-07) 
                 0.4 
                 0.2 
                 0.0 
                 0.0 
               
               
                 Ovary Margin (OD04768-08) 
                 1.0 
                 0.8 
                 0.6 
                 1.6 
               
               
                 Normal Stomach 
                 4.3 
                 2.0 
                 0.3 
                 3.1 
               
               
                 Gastric Cancer 9060358 
                 2.4 
                 0.7 
                 0.7 
                 1.2 
               
               
                 Stomach Margin 9060359 
                 0.0 
                 0.0 
                 0.7 
                 4.3 
               
               
                 Gastric Cancer 9060395 
                 0.9 
                 2.0 
                 1.9 
                 2.4 
               
               
                 Stomach Margin 9060394 
                 0.2 
                 0.3 
                 1.1 
                 0.2 
               
               
                 Gastric Cancer 9060397 
                 0.4 
                 0.5 
                 1.6 
                 0.7 
               
               
                 Stomach Margin 9060396 
                 0.0 
                 0.1 
                 0.2 
                 0.2 
               
               
                 Gastric Cancer 064005 
                 0.7 
                 0.7 
                 0.9 
                 1.5 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag047, Run 144771648    
               
               
                   Column B - Rel. Exp. (%) Ag047, Run 152940364    
               
               
                   Column C - Rel. Exp. (%) Ag2679, Run 158633803    
               
               
                   Column D - Rel. Exp. (%) Ag2728, Run 158561830    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE FI 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Daoy- Medulloblastoma 
                 0.9 
               
               
                   
                 TE671- Medulloblastoma 
                 0.0 
               
               
                   
                 D283 Med- Medulloblastoma 
                 0.0 
               
               
                   
                 PFSK-1- Primitive Neuroectodermal 
                 0.0 
               
               
                   
                 XF-498- CNS 
                 0.0 
               
               
                   
                 SNB-78- Glioma 
                 100.0 
               
               
                   
                 SF-268- Glioblastoma 
                 79.0 
               
               
                   
                 T98G- Glioblastoma 
                 1.4 
               
               
                   
                 SK-N-SH- Neuroblastoma (metastasis) 
                 2.0 
               
               
                   
                 SF-295- Glioblastoma 
                 0.1 
               
               
                   
                 Cerebellum 
                 4.5 
               
               
                   
                 Cerebellum 
                 2.9 
               
               
                   
                 NCI-H292- Mucoepidermoid lung carcinoma 
                 3.8 
               
               
                   
                 DMS-114- Small cell lung cancer 
                 0.0 
               
               
                   
                 DMS-79- Small cell lung cancer 
                 0.1 
               
               
                   
                 NCI-H146- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H526- Small cell lung cancer 
                 1.0 
               
               
                   
                 NCI-N417- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H82- Small cell lung cancer 
                 7.6 
               
               
                   
                 NCI-H157- Squamous cell lung cancer (metastasis) 
                 0.8 
               
               
                   
                 NCI-H1155- Large cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H1299- Large cell lung cancer 
                 0.2 
               
               
                   
                 NCI-H727- Lung carcinoid 
                 0.0 
               
               
                   
                 NCI-UMC-11- Lung carcinoid 
                 0.0 
               
               
                   
                 LX-1- Small cell lung cancer 
                 0.0 
               
               
                   
                 Colo-205- Colon cancer 
                 0.0 
               
               
                   
                 KM12- Colon cancer 
                 0.0 
               
               
                   
                 KM20L2- Colon cancer 
                 0.0 
               
               
                   
                 NCI-H716- Colon cancer 
                 0.0 
               
               
                   
                 SW-48- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW1116- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 LS 174T- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-948- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-480- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-5- Gastric carcinoma 
                 0.7 
               
               
                   
                 KATO III- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-16- Gastric carcinoma 
                 0.2 
               
               
                   
                 NCI-SNU-1- Gastric carcinoma 
                 0.0 
               
               
                   
                 RF-1- Gastric adenocarcinoma 
                 0.3 
               
               
                   
                 RF-48- Gastric adenocarcinoma 
                 0.1 
               
               
                   
                 MKN-45- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-N87- Gastric carcinoma 
                 0.0 
               
               
                   
                 OVCAR-5- Ovarian carcinoma 
                 0.0 
               
               
                   
                 RL95-2- Uterine carcinoma 
                 4.0 
               
               
                   
                 HelaS3- Cervical adenocarcinoma 
                 0.0 
               
               
                   
                 Ca Ski- Cervical epidermoid carcinoma (metastasis) 
                 0.3 
               
               
                   
                 ES-2- Ovarian clear cell carcinoma 
                 6.7 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 0.0 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 0.0 
               
               
                   
                 MEG-01- Chronic myelogenous leukemia 
                 0.0 
               
               
                   
                 (megokaryoblast) 
               
               
                   
                 Raji- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 Daudi- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 U266- B-cell plasmacytoma 
                 0.0 
               
               
                   
                 CA46- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 0.0 
               
               
                   
                 JM1- pre-B-cell lymphoma 
                 0.0 
               
               
                   
                 Jurkat- T cell leukemia 
                 0.0 
               
               
                   
                 TF-1- Erythroleukemia 
                 0.0 
               
               
                   
                 HUT 78- T-cell lymphoma 
                 0.0 
               
               
                   
                 U937- Histiocytic lymphoma 
                 0.0 
               
               
                   
                 KU-812- Myelogenous leukemia 
                 0.0 
               
               
                   
                 769-P- Clear cell renal carcinoma 
                 0.1 
               
               
                   
                 Caki-2- Clear cell renal carcinoma 
                 0.1 
               
               
                   
                 SW 839- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 Rhabdoid kidney tumor 
                 6.0 
               
               
                   
                 Hs766T- Pancreatic carcinoma (LN metastasis) 
                 0.0 
               
               
                   
                 CAPAN-1- Pancreatic adenocarcinoma (liver metastasis) 
                 0.0 
               
               
                   
                 SU86.86- Pancreatic carcinoma (liver metastasis) 
                 0.1 
               
               
                   
                 BxPC-3- Pancreatic adenocarcinoma 
                 0.6 
               
               
                   
                 HPAC- Pancreatic adenocarcinoma 
                 0.0 
               
               
                   
                 MIA PaCa-2- Pancreatic carcinoma 
                 0.0 
               
               
                   
                 CFPAC-1- Pancreatic ductal adenocarcinoma 
                 0.1 
               
               
                   
                 PANC-1- Pancreatic epithelioid ductal carcinoma 
                 0.0 
               
               
                   
                 T24- Bladder carcinma (transitional cell) 
                 0.0 
               
               
                   
                 5637- Bladder carcinoma 
                 3.8 
               
               
                   
                 HT-1197- Bladder carcinoma 
                 0.0 
               
               
                   
                 UM-UC-3- Bladder carcinma (transitional cell) 
                 10.3 
               
               
                   
                 A204- Rhabdomyosarcoma 
                 0.0 
               
               
                   
                 HT-1080- Fibrosarcoma 
                 59.9 
               
               
                   
                 MG-63- Osteosarcoma 
                 0.5 
               
               
                   
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 4.2 
               
               
                   
                 SJRH30- Rhabdomyosarcoma (met to bone marrow) 
                 0.3 
               
               
                   
                 A431- Epidermoid carcinoma 
                 0.6 
               
               
                   
                 WM266-4- Melanoma 
                 0.0 
               
               
                   
                 DU 145- Prostate carcinoma (brain metastasis) 
                 0.0 
               
               
                   
                 MDA-MB-468- Breast adenocarcinoma 
                 0.0 
               
               
                   
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.2 
               
               
                   
                 SCC-9- Squamous cell carcinoma of tongue 
                 1.1 
               
               
                   
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.3 
               
               
                   
                 CAL 27- Squamous cell carcinoma of tongue 
                 7.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag047, Run 158634002    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE FJ 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Secondary Th1 act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 act 
                 0.0 
                 0.0 
                 0.1 
               
               
                 Secondary Tr1 act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Th1 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 rest 
                 0.0 
                 0.0 
                 0.2 
               
               
                 Secondary Tr1 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th1 act 
                 0.0 
                 0.0 
                 0.1 
               
               
                 Primary Th2 act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th1 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th2 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CD45RA CD4 lymphocyte act 
                 0.6 
                 0.8 
                 1.7 
               
               
                 CD45RO CD4 lymphocyte act 
                 0.2 
                 0.0 
                 0.2 
               
               
                 CD8 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte rest 
                 0.1 
                 0.1 
                 0.0 
               
               
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CD4 lymphocyte none 
                 0.0 
                 0.0 
                 0.2 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 
                 0.0 
                 0.0 
                 0.1 
               
               
                 LAK cells IL-2 + IL-12 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IFN gamma 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-18 
                 0.0 
                 0.1 
                 0.2 
               
               
                 LAK cells PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
               
               
                 NK Cells IL-2 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 3 day 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 5 day 
                 0.0 
                 0.0 
                 0.1 
               
               
                 Two Way MLR 7 day 
                 0.0 
                 0.1 
                 0.0 
               
               
                 PBMC rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 PBMC PWM 
                 0.0 
                 0.0 
                 0.0 
               
               
                 PBMC PHA-L 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) none 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
                 0.0 
               
               
                 B lymphocytes PWM 
                 0.0 
                 0.0 
                 0.0 
               
               
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP 
                 0.0 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells none 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells LPS 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells anti-CD40 
                 0.0 
                 0.1 
                 0.3 
               
               
                 Monocytes rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Monocytes LPS 
                 0.0 
                 0.0 
                 0.2 
               
               
                 Macrophages rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Macrophages LPS 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC none 
                 0.0 
                 0.0 
                 0.3 
               
               
                 HUVEC starved 
                 0.0 
                 0.4 
                 0.2 
               
               
                 HUVEC IL-1beta 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC IFN gamma 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
                 0.0 
                 0.2 
               
               
                 HUVEC TNF alpha + IL4 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-11 
                 0.0 
                 0.0 
                 0.2 
               
               
                 Lung Microvascular EC none 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung Microvascular EC TNFalpha + 
                 0.0 
                 1.1 
                 0.0 
               
               
                 IL-1beta 
               
               
                 Microvascular Dermal EC none 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Microsvasular Dermal EC 
                 0.0 
                 0.0 
                 0.0 
               
               
                 TNFalpha + IL-1beta 
               
               
                 Bronchial epithelium TNFalpha + 
                 17.3 
                 37.4 
                 28.5 
               
               
                 IL1beta 
               
               
                 Small airway epithelium none 
                 40.3 
                 47.6 
                 49.0 
               
               
                 Small airway epithelium TNFalpha + 
                 100.0 
                 100.0 
                 100.0 
               
               
                 IL-1beta 
               
               
                 Coronery artery SMC rest 
                 0.7 
                 0.8 
                 0.4 
               
               
                 Coronery artery SMC TNFalpha + IL- 
                 0.5 
                 0.6 
                 1.3 
               
               
                 1beta 
               
               
                 Astrocytes rest 
                 26.1 
                 51.8 
                 24.5 
               
               
                 Astrocytes TNFalpha + IL-1 beta 
                 24.1 
                 78.5 
                 42.6 
               
               
                 KU-812 (Basophil) rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) none 
                 52.5 
                 45.1 
                 90.1 
               
               
                 CCD1106 (Keratinocytes) 
                 14.4 
                 33.7 
                 20.9 
               
               
                 TNFalpha + IL-1 beta 
               
               
                 Liver cirrhosis 
                 0.3 
                 0.2 
                 0.2 
               
               
                 NCI-H292 none 
                 0.4 
                 0.5 
                 0.7 
               
               
                 NCI-H292 IL-4 
                 9.9 
                 12.6 
                 19.1 
               
               
                 NCI-H292 IL-9 
                 0.8 
                 0.6 
                 1.6 
               
               
                 NCI-H292 IL-13 
                 14.0 
                 10.9 
                 13.2 
               
               
                 NCI-H292 IFN gamma 
                 0.1 
                 0.9 
                 0.4 
               
               
                 HPAEC none 
                 0.0 
                 1.2 
                 0.4 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
                 0.3 
                 0.0 
               
               
                 Lung fibroblast none 
                 0.7 
                 1.5 
                 1.6 
               
               
                 Lung fibroblast TNF alpha + IL-1 
                 0.2 
                 0.0 
                 0.7 
               
               
                 beta 
               
               
                 Lung fibroblast IL-4 
                 0.1 
                 0.1 
                 0.0 
               
               
                 Lung fibroblast IL-9 
                 0.2 
                 0.2 
                 0.1 
               
               
                 Lung fibroblast IL-13 
                 0.2 
                 1.3 
                 0.4 
               
               
                 Lung fibroblast IFN gamma 
                 0.0 
                 0.8 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 rest 
                 4.8 
                 4.1 
                 5.7 
               
               
                 Dermal fibroblast CCD1070 TNF 
                 1.3 
                 2.2 
                 2.1 
               
               
                 alpha 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 1.1 
                 0.8 
                 1.8 
               
               
                 Dermal fibroblast IFN gamma 
                 3.1 
                 2.4 
                 3.4 
               
               
                 Dermal fibroblast IL-4 
                 3.9 
                 5.4 
                 6.0 
               
               
                 Dermal Fibroblasts rest 
                 7.4 
                 9.3 
                 9.3 
               
               
                 Neutrophils TNFa + LPS 
                 0.0 
                 0.6 
                 0.0 
               
               
                 Neutrophils rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Colon 
                 0.0 
                 0.5 
                 0.0 
               
               
                 Lung 
                 0.1 
                 1.6 
                 0.1 
               
               
                 Thymus 
                 1.6 
                 9.3 
                 2.3 
               
               
                 Kidney 
                 1.5 
                 11.3 
                 1.7 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag047, Run 264524965    
               
               
                   Column B - Rel. Exp. (%) Ag2975, Run 171818669    
               
               
                   Column C - Rel. Exp. (%) Ag47b, Run 263594820    
               
            
           
         
       
     
      Panel 1 Summary: Ag047/Ag332/Ag47b Highest expression of this gene was detected in a brain cancer cell line (CTs=23-25). There was also significant expression in clusters of samples from melanoma, ovarian cancer, breast, lung, renal colon and brain cancer lines. Expression of this gene is associated with these forms of cancer and is useful as a diagnostic marker for the presence of these cancers. Therapeutic modulation of the expression or function of these genes or gene products is useful in the treatment of ovarian, breast, lung, renal, and brain cancer and melanoma.  
      In addition to significant expression in brain cancer cell lines, this gene was preferentially expressed in the brain. This expression profile shows that this gene product plays a role in CNS processes. This gene encodes a homolog of a member of the neurestin farnily, Ten M2, and plays a role in neuronal regeneration. (Otaki, J. Dev Biol 1999 August 1;212(1):165-81 ) Agents that induce the expression or activity of this gene or gene product have utility as neuronal regeneration drugs and specifically for the treatment of neurodegenerative diseases, stroke, and neuronal trauma.  
      Among tissues with metabolic function, this gene showed consistent expression in thyroid, adult and fetal heart, liver and skeletal muscle. Thus, this gene product is an antibody target for the treatment of metabolic and endocrine disease, including obesity and Types 1 and 2 diabetes. In addition, this gene was eressed at higher levels in adult liver than in fetal liver and is be useful for differentiating between the two sources of liver tissue.  
      Panel 2D Summary: Ag047/Ag2679/Ag2728 Highest expression of this gene was detected in lung cancer samples (CTs=27-29). This gene was expressed at a higher level in gastric, bladder, and two samples each of lung and kidney cancer relative to the normal adjacent tissues. Expression of this gene is useful as a marker to detect the presence of these cancers. Therapeutic modulation of this gene, expressed protein and/or use of antibodies, protein therapeutics or small molecule drugs are useful in the treatment of these cancers.  
      Panel 3D Summary: Ag047 This gene was expressed in squamous cell carcinoma, glioma, small cell lung cancer cell lines. Expression of this gene is associated with these cancers and therapeutic modulation of this gene expressed protein and/or use of antibodies, protein therapeutics or small molecule drugs is of use in the treatment of these cancers.  
      Panel 4.1D Summary: Ag047/Ag047b/Ag2975 Highest expression of this gene was detected in activated small airway epithelium (CT=27-32). This gene was expressed at moderate level in small airway epithelium, astrocytes and keratinocytes. The expression of this gene in these tissues was up-regulated upon treatment with the inflammatory cytokines TNF-a and IL1. This gene encodes for a neurestin like molecule whose role in neuronal regeneration has been demonstrated. Modulation of the expression of this gene or its expressed protein is useful in the regeneration or repair mechanism of these tissues during inflammation and for the treatment of inflammatory brain and lung diseases such as bronchitis, chronic pulmonary diseases, skin and CNS inflammatory diseases, multiple sclerosis or stroke.  
      G. CG50646-04: Polydom Protein  
      Expression of gene CG50646-04 was assessed using the primer-probe sets Ag768 and Ag984, described in Tables GA and GB. Results of the RTQ-PCR runs are shown in Tables GC and GD.  
               TABLE GA                          Probe Name Ag768                                 Primers   Sequences   Length   Start Position   SEQ ID No                                             Forward   5′-gggctataagtcagtcggaagt-3′   22   6772   1258                   Probe   TET-5′-cctgtatttgtctgccaagccaatcg-3′-TAMRA   26   6794   1259               Reverse   5′-acagtcgagaggaacacacatc-3′   22   6844   1260                  
 
     
       
         
           
               
             
               
                 TABLE GB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag984 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-cccgggttacactgatacct-3′ 
                 20 
                 6755 
                 1261 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-tgctccagaaagccattctcaacctt-3′- 
                 26 
                 6698 
                 1262 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-cggtatcttgtggtgaacca-3′ 
                 20 
                 6675 
                 1263 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE GC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.2 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Endothelial cells 
                 0.0 
               
               
                   
                 Heart (Fetal) 
                 0.0 
               
               
                   
                 Pancreas 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
               
               
                   
                 Adrenal Gland 
                 0.1 
               
               
                   
                 Thyroid 
                 0.0 
               
               
                   
                 Salivary gland 
                 0.0 
               
               
                   
                 Pituitary gland 
                 0.0 
               
               
                   
                 Brain (fetal) 
                 0.0 
               
               
                   
                 Brain (whole) 
                 0.0 
               
               
                   
                 Brain (amygdala) 
                 0.0 
               
               
                   
                 Brain (cerebellum) 
                 0.0 
               
               
                   
                 Brain (hippocampus) 
                 0.0 
               
               
                   
                 Brain (thalamus) 
                 0.0 
               
               
                   
                 Cerebral Cortex 
                 0.0 
               
               
                   
                 Spinal cord 
                 0.0 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.0 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.0 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 0.0 
               
               
                   
                 glioma SNB-19 
                 0.0 
               
               
                   
                 glioma U251 
                 0.0 
               
               
                   
                 glioma SF-295 
                 0.0 
               
               
                   
                 Heart 
                 0.1 
               
               
                   
                 Skeletal Muscle 
                 0.2 
               
               
                   
                 Bone marrow 
                 0.0 
               
               
                   
                 Thymus 
                 0.0 
               
               
                   
                 Spleen 
                 0.0 
               
               
                   
                 Lymph node 
                 0.7 
               
               
                   
                 Colorectal Tissue 
                 0.0 
               
               
                   
                 Stomach 
                 0.0 
               
               
                   
                 Small intestine 
                 0.8 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* SW620 (SW480 met) 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon ca. Tissue (ODO3866) 
                 0.0 
               
               
                   
                 Colon ca. HCC-2998 
                 0.0 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.0 
               
               
                   
                 Bladder 
                 0.0 
               
               
                   
                 Trachea 
                 0.0 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                 Kidney (fetal) 
                 0.0 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Liver (fetal) 
                 0.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
               
               
                   
                 Lung 
                 0.6 
               
               
                   
                 Lung (fetal) 
                 0.0 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.0 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
               
               
                   
                 Mammary gland 
                 4.4 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Ovary 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 0.0 
               
               
                   
                 Uterus 
                 0.2 
               
               
                   
                 Placenta 
                 100.0 
               
               
                   
                 Prostate 
                 0.0 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Testis 
                 0.0 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
               
               
                   
                 Melanoma M14 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag768, Run 116422776    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE GD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.1 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.1 
               
               
                   
                 Secondary Th2 rest 
                 0.1 
               
               
                   
                 Secondary Tr1 rest 
                 0.2 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.2 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 6.4 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.1 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.1 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.1 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.2 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.1 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.3 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.2 
               
               
                   
                 LAK cells PMA/ionomycin 
                 3.5 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 2.5 
               
               
                   
                 PBMC PHA-L 
                 0.3 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.1 
               
               
                   
                 B lymphocytes PWM 
                 0.1 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.2 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.1 
               
               
                   
                 Monocytes rest 
                 0.1 
               
               
                   
                 Monocytes LPS 
                 3.1 
               
               
                   
                 Macrophages rest 
                 0.1 
               
               
                   
                 Macrophages LPS 
                 3.3 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.2 
               
               
                   
                 HUVEC IL-1beta 
                 0.2 
               
               
                   
                 HUVEC IFN gamma 
                 0.3 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.1 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.1 
               
               
                   
                 HUVEC IL-11 
                 0.1 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.1 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.2 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.2 
               
               
                   
                 Small airway epithelium none 
                 2.3 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 1.3 
               
               
                   
                 Coronery artery SMC rest 
                 15.1 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 8.2 
               
               
                   
                 Astrocytes rest 
                 1.8 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 2.4 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.4 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 1.4 
               
               
                   
                 Liver cirrhosis 
                 10.6 
               
               
                   
                 Lupus kidney 
                 7.0 
               
               
                   
                 NCI-H292 none 
                 24.1 
               
               
                   
                 NCI-H292 IL-4 
                 21.6 
               
               
                   
                 NCI-H292 IL-9 
                 30.4 
               
               
                   
                 NCI-H292 IL-13 
                 15.3 
               
               
                   
                 NCI-H292 IFN gamma 
                 14.6 
               
               
                   
                 HPAEC none 
                 0.4 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 31.0 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 7.7 
               
               
                   
                 Lung fibroblast IL-4 
                 55.5 
               
               
                   
                 Lung fibroblast IL-9 
                 37.4 
               
               
                   
                 Lung fibroblast IL-13 
                 86.5 
               
               
                   
                 Lung fibroblast IFN gamma 
                 100.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 28.9 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 23.7 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 20.2 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 22.5 
               
               
                   
                 Dermal fibroblast IL-4 
                 47.0 
               
               
                   
                 IBD Colitis 2 
                 0.5 
               
               
                   
                 IBD Crohn&#39;s 
                 2.0 
               
               
                   
                 Colon 
                 9.2 
               
               
                   
                 Lung 
                 20.3 
               
               
                   
                 Thymus 
                 13.0 
               
               
                   
                 Kidney 
                 6.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag768, Run 138175130    
               
            
           
         
       
     
      Panel 1.2 Summary: Ag768 Highest expression of this gene was seen in placenta (CT=21). This gene encodes a polydom-like protein and was also highly expressed in mammary gland, skeletal muscle. This gene may be involved in cellular adhesion (Gilges D. Biochem J 2000 November 15;352 Pt 1:49-59). Expression of this gene is useful in differentiating between placental tissues and other tissues on this panel. Modulation of this gene or its protein product is useful in reproductive and skeletal muscle physiology.  
      This gene was more highly expressed in fetal kidney (CT=33) than in adult kidney (CT=40). Conversely, this gene was more highly expressed in adult lung and liver (CTs=28-32) than in fetal lung and liver (CTs=38-40). Thus, expression of this gene is useful in differentiating between the adult and fetal sources of these tissues.  
      Panel 4D Summary: Ag768 Highest expression of this gene was seen in lung fibroblasts stimulated with IFN-gamma (CT=27.4). Significant expression was seen in many samples derived from the lung including lung fibroblasts stimulated with different cytokines, the pulmonary mucoepidermoid cell line H292 stimulated with the same cytokines, and normal lung tissue. The expression of this gene in lung cells and lung tissue shows that this gene or its protein product is involved in normal homeostasis of the lung, as well as pathological and inflammatory lung disorders, including chronic obstructive pulmonary disease, asthma, allergy and emphysema.  
      Significant levels of expression of this gene in dermal fibroblasts show that this gene and its protein product is involved in skin disorders, including psoriasis.  
      Moderate to low expression of this gene was also seen in many other cells with important immune function, including stimulated macrophages and monocytes, coronary artery smooth muscle cells, stimulated peripheral blood mononuclear cells, lymphocyte activated killer cells (LAK), astrocytes, activated CD45RA cells, and normal colon, thymus and kidney. This widespread expression demonstrates that this gene or the protein encoded by this gene is involved in other inflammatory and autoimmune conditions, including inflammatory bowel disease, rheumatoid arthritis and osteoarthritis.  
      H. CG5073609: CD44-Like Precursor Fell  
      Expression of gene CG50736-09 was assessed using the primer-probe sets Ag2742, Ag2743, Ag2744, Ag2745, Ag2746, Ag793, Ag812, Ag03 and Ag068, described in Tables HA, HB, HC, HD, HE, HF, HG, HH and HI. Results of the RTQ-PCR runs are shown in Tables HJ, HK, HL, HM, HN and HO.  
               TABLE HA                          Probe Name Ag2742                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-ctgcaaaatcttacgactttgg-3′   22   429   1264                   Probe   TET-5′-caacaaacaatggctacatcaaatttagca-3′-   30   451   1265           TAMRA               Reverse   5′-atgacactcagcaaacctgagt-3′   22   493   1266                  
 
     
       
         
           
               
             
               
                 TABLE HB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag2743 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-ctgcaaaatcttacgacttgg-3′ 
                 22 
                 429 
                 1267 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-caacaaacaatggctacatcaaatttagca-3′- 
                 30 
                 451 
                 1268 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-atgacactcagcaaacctgagt-3′ 
                 22 
                 493 
                 1269 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE HC 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag2744 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-ctgcaaaatcttacgactttgg-3′ 
                 22 
                 429 
                 1270 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-caacaaacaatggctacatcaaatttagca-3′- 
                 30 
                 451 
                 1271 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-tcagcaaacctgagtcctgta-3′ 
                 21 
                 487 
                 1272 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE HD 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag2745 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-ctgcaaaatcttacgactttgg-3′ 
                 22 
                 429 
                 1273 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-caacaaacaatggctacatcaaatttagca-3′- 
                 30 
                 451 
                 1274 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-atgacactcagcaaacctgagt-3′ 
                 22 
                 493 
                 1275 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE HD 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag2746 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-ctgcaaaatcttacgactttgg-3′ 
                 22 
                 429 
                 1276 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-caacaaacaatggctacatcaaatttagca-3′- 
                 30 
                 451 
                 1277 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-atgacactcagcaaacctgagt-3′ 
                 22 
                 493 
                 1278 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE HF 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag793 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-ccaaggttttagctgtggatct-3′ 
                 22 
                 664 
                 1279 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-acatccactgcctggaagaccctg-3′- 
                 24 
                 690 
                 1280 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-cacatttcacactcagctctga-3′ 
                 22 
                 720 
                 1281 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE HG 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag812 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-caggagcatttcgtgaaaga-3′ 
                 20 
                 57 
                 1282 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ttttgcacctttatctgcagcctttg-3′- 
                 26 
                 104 
                 1283 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-tttaacccgagcttcctcat-3′ 
                 20 
                 130 
                 1284 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE HH 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag03 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-ctggttgtaggttgccatggt-3′ 
                 21 
                 1884 
                 1285 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-cagcttcgttggcacaggcctctc-3′- 
                 24 
                 1858 
                 1286 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-ccagtataagctgacctttgacaaag-3′ 
                 26 
                 1829 
                 1287 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE HI 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag068 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-ctggttgtaggttgccatggt-3′ 
                 21 
                 1884 
                 1288 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-cagcttcgttggcacaggcctctc-3′- 
                 24 
                 1858 
                 1289 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-ccagtataagctgacctttgacaaag-3′ 
                 26 
                 1829 
                 1290 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE HJ 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Endothelial cells 
                 0.0 
                 0.0 
               
               
                   
                 Endothelial cells (treated) 
                 0.0 
                 0.0 
               
               
                   
                 Pancreas 
                 0.0 
                 2.3 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
                 0.0 
               
               
                   
                 Adrenal gland 
                 0.5 
                 1.3 
               
               
                   
                 Thyroid 
                 1.8 
                 2.1 
               
               
                   
                 Salivary gland 
                 2.5 
                 3.0 
               
               
                   
                 Pituitary gland 
                 0.8 
                 0.8 
               
               
                   
                 Brain (fetal) 
                 0.1 
                 0.4 
               
               
                   
                 Brain (whole) 
                 0.3 
                 0.6 
               
               
                   
                 Brain (amygdala) 
                 0.1 
                 0.4 
               
               
                   
                 Brain (cerebellum) 
                 0.4 
                 0.7 
               
               
                   
                 Brain (hippocampus) 
                 0.3 
                 0.9 
               
               
                   
                 Brain (substantia nigra) 
                 0.1 
                 0.3 
               
               
                   
                 Brain (thalamus) 
                 0.1 
                 0.2 
               
               
                   
                 Brain (hypothalamus) 
                 0.4 
                 0.5 
               
               
                   
                 Spinal cord 
                 0.0 
                 0.3 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
                 0.1 
               
               
                   
                 glio/astro U-118-MG 
                 0.1 
                 0.2 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
                 0.1 
               
               
                   
                 astrocytoma SNB-75 
                 0.1 
                 0.2 
               
               
                   
                 glioma SNB-19 
                 0.6 
                 1.6 
               
               
                   
                 glioma U251 
                 0.2 
                 0.9 
               
               
                   
                 glioma SF-295 
                 0.1 
                 0.2 
               
               
                   
                 Heart 
                 0.3 
                 0.3 
               
               
                   
                 Skeletal muscle 
                 0.3 
                 0.4 
               
               
                   
                 Bone marrow 
                 3.5 
                 3.0 
               
               
                   
                 Thymus 
                 0.3 
                 0.2 
               
               
                   
                 Spleen 
                 100.0 
                 100.0 
               
               
                   
                 Lymph node 
                 29.3 
                 81.2 
               
               
                   
                 Colon (ascending) 
                 0.8 
                 1.0 
               
               
                   
                 Stomach 
                 1.2 
                 1.5 
               
               
                   
                 Small intestine 
                 1.6 
                 1.7 
               
               
                   
                 Colon ca. SW480 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca.* SW620 (SW480 met) 
                 0.0 
                 0.1 
               
               
                   
                 Colon ca. HT29 
                 0.0 
                 0.1 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.1 
                 0.1 
               
               
                   
                 Colon ca. HCT-15 
                 0.1 
                 0.7 
               
               
                   
                 Colon ca. HCC-2998 
                 0.0 
                 0.3 
               
               
                   
                 Gastric ca. * (liver met) NCI-N87 
                 0.1 
                 0.2 
               
               
                   
                 Bladder 
                 1.1 
                 0.2 
               
               
                   
                 Trachea 
                 2.4 
                 2.2 
               
               
                   
                 Kidney 
                 0.1 
                 0.4 
               
               
                   
                 Kidney (fetal) 
                 1.0 
                 1.3 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.1 
                 0.5 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
                 0.1 
               
               
                   
                 Renal ca. TK-10 
                 0.2 
                 0.9 
               
               
                   
                 Liver 
                 14.2 
                 12.9 
               
               
                   
                 Liver (fetal) 
                 25.7 
                 15.6 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
                 0.1 
               
               
                   
                 Lung 
                 0.5 
                 0.1 
               
               
                   
                 Lung (fetal) 
                 4.4 
                 6.2 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.1 
                 0.4 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.0 
                 0.1 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
                 0.3 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.0 
                 0.1 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
                 0.1 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.1 
                 0.3 
               
               
                   
                 Mammary gland 
                 4.7 
                 5.1 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
                 0.2 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.1 
                 0.4 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.1 
                 0.4 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.1 
                 0.6 
               
               
                   
                 Ovary 
                 3.6 
                 1.3 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
                 0.1 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.1 
                 0.6 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.2 
                 0.7 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
                 0.3 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 0.0 
                 0.2 
               
               
                   
                 Uterus 
                 0.2 
                 0.4 
               
               
                   
                 Placenta 
                 1.9 
                 1.6 
               
               
                   
                 Prostate 
                 0.7 
                 1.0 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
                 0.0 
               
               
                   
                 Testis 
                 23.5 
                 22.1 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
                 0.1 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
                 0.1 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma M14 
                 0.1 
                 0.5 
               
               
                   
                 Melanoma LOX IMVI 
                 0.1 
                 0.5 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma SK-MEL-28 
                 0.3 
                 1.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag03, Run 87353672    
               
               
                   
                   Column B - Rel. Exp. (%) Ag068, Run 87361479    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE HK 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.2 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Endothelial cells 
                 0.0 
                 0.0 
               
               
                   
                 Heart (Fetal) 
                 0.3 
                 5.6 
               
               
                   
                 Pancreas 
                 2.0 
                 0.6 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
                 0.0 
               
               
                   
                 Adrenal Gland 
                 0.3 
                 0.9 
               
               
                   
                 Thyroid 
                 2.0 
                 0.7 
               
               
                   
                 Salivary gland 
                 6.3 
                 6.7 
               
               
                   
                 Pituitary gland 
                 0.1 
                 0.4 
               
               
                   
                 Brain (fetal) 
                 0.1 
                 0.0 
               
               
                   
                 Brain (whole) 
                 1.2 
                 0.1 
               
               
                   
                 Brain (amygdala) 
                 0.0 
                 0.1 
               
               
                   
                 Brain (cerebellum) 
                 7.6 
                 0.0 
               
               
                   
                 Brain (hippocampus) 
                 0.1 
                 0.2 
               
               
                   
                 Brain (thalamus) 
                 0.0 
                 0.0 
               
               
                   
                 Cerebral Cortex 
                 0.1 
                 0.1 
               
               
                   
                 Spinal cord 
                 0.0 
                 0.1 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
                 0.1 
               
               
                   
                 astrocytoma SNB-75 
                 0.0 
                 0.0 
               
               
                   
                 glioma SNB-19 
                 0.0 
                 0.1 
               
               
                   
                 glioma U251 
                 0.0 
                 0.1 
               
               
                   
                 glioma SF-295 
                 0.0 
                 0.0 
               
               
                   
                 Heart 
                 0.8 
                 1.8 
               
               
                   
                 Skeletal Muscle 
                 2.4 
                 1.5 
               
               
                   
                 Bone marrow 
                 2.7 
                 3.5 
               
               
                   
                 Thymus 
                 0.2 
                 0.3 
               
               
                   
                 Spleen 
                 44.8 
                 44.4 
               
               
                   
                 Lymph node 
                 39.2 
                 51.8 
               
               
                   
                 Colorectal Tissue 
                 0.0 
                 0.2 
               
               
                   
                 Stomach 
                 1.0 
                 2.9 
               
               
                   
                 Small intestine 
                 1.2 
                 2.7 
               
               
                   
                 Colon ca. SW480 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca.* SW620 (SW480 met) 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
                 0.1 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. Tissue (ODO3866) 
                 0.1 
                 0.4 
               
               
                   
                 Colon ca. HCC-2998 
                 0.0 
                 0.0 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.0 
                 0.1 
               
               
                   
                 Bladder 
                 3.7 
                 3.8 
               
               
                   
                 Trachea 
                 1.1 
                 1.9 
               
               
                   
                 Kidney 
                 0.1 
                 0.4 
               
               
                   
                 Kidney (fetal) 
                 0.8 
                 2.1 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.3 
                 0.1 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
                 0.0 
               
               
                   
                 Liver 
                 100.0 
                 100.0 
               
               
                   
                 Liver (fetal) 
                 37.9 
                 58.2 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
                 0.0 
               
               
                   
                 Lung 
                 0.4 
                 0.8 
               
               
                   
                 Lung (fetal) 
                 2.4 
                 2.5 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.1 
                 0.6 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (large cell) NCI-H460 
                 0.0 
                 0.2 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.1 
                 0.2 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
                 0.1 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.1 
                 0.2 
               
               
                   
                 Mammary gland 
                 2.9 
                 2.3 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.1 
                 0.3 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
                 0.1 
               
               
                   
                 Ovary 
                 1.4 
                 4.2 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 2.9 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 4.1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.2 
                 0.3 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
                 0.1 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 0.0 
                 0.0 
               
               
                   
                 Uterus 
                 0.2 
                 0.7 
               
               
                   
                 Placenta 
                 0.8 
                 0.9 
               
               
                   
                 Prostate 
                 0.3 
                 0.5 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
                 0.0 
               
               
                   
                 Testis 
                 12.2 
                 8.4 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
                 0.1 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma M14 
                 0.1 
                 0.2 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.1 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag812, Run 118348259    
               
               
                   
                   Column B - Rel. Exp. (%) Ag812, Run 121953945    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE HL 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
                 D 
                 E 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Liver adenocarcinoma 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Pancreas 
                 0.2 
                 0.4 
                 0.3 
                 0.2 
                 0.2 
               
               
                 Pancreatic ca. CAPAN 2 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Adrenal gland 
                 0.2 
                 0.0 
                 0.0 
                 0.4 
                 0.2 
               
               
                 Thyroid 
                 0.5 
                 0.6 
                 1.1 
                 1.4 
                 0.6 
               
               
                 Salivary gland 
                 1.0 
                 1.0 
                 0.7 
                 0.7 
                 0.1 
               
               
                 Pituitary gland 
                 0.0 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
               
               
                 Brain (fetal) 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Brain (whole) 
                 0.0 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
               
               
                 Brain (amygdala) 
                 0.0 
                 0.3 
                 0.1 
                 0.0 
                 0.0 
               
               
                 Brain (cerebellum) 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Brain (hippocampus) 
                 0.3 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
               
               
                 Brain (substantia nigra) 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Brain (thalamus) 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Cerebral Cortex 
                 0.0 
                 0.0 
                 0.0 
                 0.1 
                 0.0 
               
               
                 Spinal cord 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 glio/astro U87-MG 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 glio/astro U-118-MG 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 astrocytoma SW1783 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 neuro*; met SK-N-AS 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 astrocytoma SF-539 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 astrocytoma SNB-75 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 glioma SNB-19 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 glioma U251 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 glioma SF-295 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Heart (fetal) 
                 1.8 
                 0.7 
                 2.1 
                 2.1 
                 1.5 
               
               
                 Heart 
                 0.1 
                 0.2 
                 0.0 
                 0.1 
                 0.2 
               
               
                 Skeletal muscle (fetal) 
                 8.5 
                 6.9 
                 9.3 
                 9.5 
                 6.8 
               
               
                 Skeletal muscle 
                 0.0 
                 0.0 
                 0.0 
                 0.1 
                 0.0 
               
               
                 Bone marrow 
                 2.6 
                 2.2 
                 3.3 
                 2.4 
                 3.1 
               
               
                 Thymus 
                 0.1 
                 0.0 
                 0.1 
                 0.1 
                 0.2 
               
               
                 Spleen 
                 100.0 
                 100.0 
                 100.0 
                 100.0 
                 100.0 
               
               
                 Lymph node 
                 20.7 
                 17.9 
                 25.5 
                 26.4 
                 32.8 
               
               
                 Colorectal 
                 1.6 
                 1.1 
                 0.6 
                 0.7 
                 0.4 
               
               
                 Stomach 
                 1.3 
                 0.5 
                 1.2 
                 0.7 
                 0.9 
               
               
                 Small intestine 
                 1.3 
                 1.0 
                 1.1 
                 1.1 
                 1.2 
               
               
                 Colon ca. SW480 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Colon ca.* SW620(SW480 met) 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Colon ca. HT29 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Colon ca. HCT-116 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Colon ca. CaCo-2 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Colon ca. tissue(ODO3866) 
                 0.1 
                 0.1 
                 0.0 
                 0.2 
                 0.1 
               
               
                 Colon ca. HCC-2998 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Gastric ca.* (liver met) NCI-N87 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.1 
               
               
                 Bladder 
                 0.3 
                 0.4 
                 0.6 
                 0.6 
                 0.4 
               
               
                 Trachea 
                 1.3 
                 0.7 
                 1.4 
                 1.2 
                 1.3 
               
               
                 Kidney 
                 0.0 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
               
               
                 Kidney (fetal) 
                 2.4 
                 3.4 
                 3.8 
                 2.1 
                 3.0 
               
               
                 Renal ca. 786-0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Renal ca. A498 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Renal ca. RXF 393 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Renal ca. ACHN 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Renal ca. UO-31 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Renal ca. TK-10 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Liver 
                 5.6 
                 8.8 
                 6.1 
                 6.4 
                 10.3 
               
               
                 Liver (fetal) 
                 33.4 
                 33.2 
                 33.9 
                 33.4 
                 36.6 
               
               
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung 
                 0.6 
                 0.6 
                 0.6 
                 0.7 
                 0.2 
               
               
                 Lung (fetal) 
                 2.0 
                 1.9 
                 2.4 
                 1.0 
                 3.1 
               
               
                 Lung ca. (small cell) LX-1 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung ca. (small cell) NCI-H69 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung ca. (large cell)NCI-H460 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung ca. (non-sm. cell) A549 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung ca. (non-s. cell) HOP-62 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung ca. (squam.) SW 900 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung ca. (squam.) NCI-H596 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Mammary gland 
                 1.6 
                 1.5 
                 1.1 
                 1.7 
                 1.5 
               
               
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Breast ca.* (pl. ef) T47D 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Breast ca. BT-549 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Breast ca. MDA-N 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ovary 
                 5.0 
                 5.4 
                 4.5 
                 6.0 
                 4.6 
               
               
                 Ovarian ca. OVCAR-3 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ovarian ca. OVCAR-4 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ovarian ca. OVCAR-5 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ovarian ca. OVCAR-8 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ovarian ca. IGROV-1 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Uterus 
                 0.2 
                 0.2 
                 0.5 
                 0.3 
                 0.1 
               
               
                 Placenta 
                 0.4 
                 0.0 
                 0.4 
                 0.1 
                 0.2 
               
               
                 Prostate 
                 0.2 
                 0.1 
                 0.1 
                 0.1 
                 0.1 
               
               
                 Prostate ca.* (bone met)PC-3 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Testis 
                 7.5 
                 5.9 
                 4.7 
                 6.5 
                 5.6 
               
               
                 Melanoma Hs688(A).T 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Melanoma* (met) Hs688(B).T 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Melanoma UACC-62 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Melanoma M14 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Melanoma LOX IMVI 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Melanoma* (met) SK-MEL-5 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Adipose 
                 1.0 
                 1.5 
                 0.6 
                 0.5 
                 1.1 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag2742, Run 153641674    
               
               
                   Column B - Rel. Exp. (%) Ag2743, Run 153658349    
               
               
                   Column C - Rel. Exp. (%) Ag2744, Run 153670718    
               
               
                   Column D - Rel. Exp. (%) Ag2745, Run 153664738    
               
               
                   Column E - Rel. Exp. (%) Ag2746, Run 153675151    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE HM 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
                 D 
                 E 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Normal Colon 
                 3.2 
                 3.8 
                 4.4 
                 4.8 
                 4.5 
               
               
                 CC Well to Mod Diff (ODO3866) 
                 0.1 
                 0.1 
                 0.1 
                 0.0 
                 0.0 
               
               
                 CC Margin (ODO3866) 
                 0.7 
                 0.5 
                 0.9 
                 1.2 
                 0.3 
               
               
                 CC Gr.2 rectosigmoid (ODO3868) 
                 0.2 
                 0.4 
                 0.2 
                 0.2 
                 0.1 
               
               
                 CC Margin (ODO3868) 
                 0.1 
                 0.1 
                 0.0 
                 0.2 
                 0.1 
               
               
                 CC Mod Diff (ODO3920) 
                 0.0 
                 0.1 
                 0.1 
                 0.0 
                 0.0 
               
               
                 CC Margin (ODO3920) 
                 1.1 
                 2.0 
                 3.1 
                 1.0 
                 1.4 
               
               
                 CC Gr.2 ascend colon (ODO3921) 
                 0.2 
                 0.3 
                 0.9 
                 0.5 
                 0.7 
               
               
                 CC Margin (ODO3921) 
                 0.7 
                 0.3 
                 0.9 
                 1.0 
                 0.2 
               
               
                 CC from Partial Hepatectomy (ODO4309) Mets 
                 7.6 
                 8.4 
                 10.2 
                 9.5 
                 8.8 
               
               
                 Liver Margin (ODO4309) 
                 100.0 
                 100.0 
                 100.0 
                 100.0 
                 100.0 
               
               
                 Colon mets to lung (OD04451-01) 
                 0.4 
                 0.3 
                 0.3 
                 1.5 
                 0.4 
               
               
                 Lung Margin (OD04451-02) 
                 0.2 
                 0.1 
                 0.8 
                 0.2 
                 0.2 
               
               
                 Normal Prostate 6546-1 
                 0.4 
                 0.0 
                 0.2 
                 0.1 
                 0.1 
               
               
                 Prostate Cancer (OD04410) 
                 0.2 
                 0.2 
                 0.0 
                 0.3 
                 0.0 
               
               
                 Prostate Margin (OD04410) 
                 0.0 
                 0.2 
                 0.3 
                 0.0 
                 0.6 
               
               
                 Prostate Cancer (OD04720-01) 
                 0.6 
                 0.1 
                 0.2 
                 0.2 
                 0.3 
               
               
                 Prostate Margin (OD04720-02) 
                 0.5 
                 0.5 
                 0.6 
                 0.3 
                 0.2 
               
               
                 Normal Lung 061010 
                 5.6 
                 5.2 
                 6.3 
                 8.1 
                 5.9 
               
               
                 Lung Met to Muscle (ODO4286) 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Muscle Margin (ODO4286) 
                 0.5 
                 0.0 
                 0.1 
                 0.2 
                 0.0 
               
               
                 Lung Malignant Cancer (OD03126) 
                 1.0 
                 1.0 
                 1.3 
                 0.8 
                 1.0 
               
               
                 Lung Margin (OD03126) 
                 0.9 
                 1.1 
                 0.9 
                 1.4 
                 1.4 
               
               
                 Lung Cancer (OD04404) 
                 1.3 
                 0.8 
                 1.6 
                 1.5 
                 1.4 
               
               
                 Lung Margin (OD04404) 
                 2.0 
                 2.5 
                 4.3 
                 3.4 
                 3.2 
               
               
                 Lung Cancer (OD04565) 
                 0.2 
                 0.1 
                 0.5 
                 0.0 
                 0.2 
               
               
                 Lung Margin (OD04565) 
                 0.3 
                 0.0 
                 0.3 
                 0.4 
                 0.7 
               
               
                 Lung Cancer (OD04237-01) 
                 0.4 
                 0.9 
                 1.2 
                 1.5 
                 1.2 
               
               
                 Lung Margin (OD04237-02) 
                 5.6 
                 5.4 
                 7.9 
                 6.3 
                 5.6 
               
               
                 Ocular Mel Met to Liver (ODO4310) 
                 0.2 
                 0.0 
                 0.0 
                 0.1 
                 0.4 
               
               
                 Liver Margin (ODO4310) 
                 52.9 
                 64.6 
                 79.6 
                 81.8 
                 63.3 
               
               
                 Melanoma Mets to Lung (OD04321) 
                 0.0 
                 0.0 
                 0.0 
                 0.1 
                 0.3 
               
               
                 Lung Margin (OD04321) 
                 0.2 
                 2.0 
                 0.9 
                 1.5 
                 0.5 
               
               
                 Normal Kidney 
                 0.5 
                 0.3 
                 0.3 
                 0.7 
                 0.3 
               
               
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
                 0.1 
               
               
                 Kidney Margin (OD04338) 
                 0.0 
                 0.2 
                 0.5 
                 0.1 
                 0.3 
               
               
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Kidney Margin (OD04339) 
                 0.0 
                 0.1 
                 0.1 
                 0.3 
                 0.1 
               
               
                 Kidney Ca, Clear cell type (OD04340) 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
                 0.1 
               
               
                 Kidney Margin (OD04340) 
                 0.2 
                 0.1 
                 0.8 
                 0.0 
                 0.0 
               
               
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.0 
                 0.0 
                 0.2 
                 0.0 
                 0.1 
               
               
                 Kidney Margin (OD04348) 
                 0.0 
                 0.1 
                 0.2 
                 0.1 
                 0.1 
               
               
                 Kidney Cancer (OD04622-01) 
                 0.2 
                 0.1 
                 0.1 
                 1.2 
                 0.2 
               
               
                 Kidney Margin (OD04622-03) 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Kidney Cancer (OD04450-01) 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Kidney Margin (OD04450-03) 
                 0.1 
                 0.0 
                 0.1 
                 0.1 
                 0.1 
               
               
                 Kidney Cancer 8120607 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Kidney Margin 8120608 
                 0.1 
                 0.0 
                 0.2 
                 0.0 
                 0.0 
               
               
                 Kidney Cancer 8120613 
                 0.3 
                 0.2 
                 0.2 
                 0.1 
                 0.5 
               
               
                 Kidney Margin 8120614 
                 0.3 
                 0.1 
                 0.4 
                 0.3 
                 0.0 
               
               
                 Kidney Cancer 9010320 
                 0.0 
                 0.1 
                 0.1 
                 0.1 
                 0.2 
               
               
                 Kidney Margin 9010321 
                 0.1 
                 0.0 
                 0.0 
                 0.1 
                 0.2 
               
               
                 Normal Uterus 
                 0.5 
                 0.1 
                 0.8 
                 0.1 
                 0.5 
               
               
                 Uterus Cancer 064011 
                 0.8 
                 0.7 
                 1.3 
                 0.4 
                 0.6 
               
               
                 Normal Thyroid 
                 1.8 
                 1.1 
                 1.5 
                 0.9 
                 2.3 
               
               
                 Thyroid Cancer 064010 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Thyroid Cancer A302152 
                 0.5 
                 1.0 
                 1.3 
                 0.6 
                 0.8 
               
               
                 Thyroid Margin A302153 
                 2.3 
                 2.4 
                 3.5 
                 3.9 
                 2.4 
               
               
                 Normal Breast 
                 9.0 
                 6.8 
                 9.0 
                 9.9 
                 5.5 
               
               
                 Breast Cancer (OD04566) 
                 0.1 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
               
               
                 Breast Cancer (OD04590-01) 
                 0.3 
                 0.4 
                 0.2 
                 0.7 
                 0.2 
               
               
                 Breast Cancer Mets (OD04590-03) 
                 1.7 
                 2.4 
                 2.5 
                 2.5 
                 1.4 
               
               
                 Breast Cancer Metastasis (OD04655-05) 
                 10.7 
                 13.2 
                 22.1 
                 15.6 
                 12.8 
               
               
                 Breast Cancer 064006 
                 0.5 
                 0.8 
                 0.8 
                 0.7 
                 0.7 
               
               
                 Breast Cancer 1024 
                 4.1 
                 2.5 
                 5.1 
                 3.1 
                 3.6 
               
               
                 Breast Cancer 9100266 
                 0.9 
                 0.2 
                 0.2 
                 0.2 
                 0.2 
               
               
                 Breast Margin 9100265 
                 0.7 
                 0.4 
                 1.0 
                 0.7 
                 1.2 
               
               
                 Breast Cancer A209073 
                 1.2 
                 1.2 
                 1.1 
                 1.9 
                 0.8 
               
               
                 Breast Margin A209073 
                 1.5 
                 1.0 
                 2.1 
                 1.5 
                 0.6 
               
               
                 Normal Liver 
                 27.5 
                 27.9 
                 37.4 
                 42.3 
                 27.2 
               
               
                 Liver Cancer 064003 
                 0.8 
                 0.5 
                 0.3 
                 0.6 
                 0.5 
               
               
                 Liver Cancer 1025 
                 33.7 
                 36.6 
                 36.6 
                 39.0 
                 27.5 
               
               
                 Liver Cancer 1026 
                 4.6 
                 3.6 
                 5.7 
                 5.8 
                 5.2 
               
               
                 Liver Cancer 6004-T 
                 36.9 
                 38.7 
                 50.3 
                 46.7 
                 38.7 
               
               
                 Liver Tissue 6004-N 
                 1.5 
                 1.0 
                 1.3 
                 1.3 
                 1.6 
               
               
                 Liver Cancer 6005-T 
                 4.5 
                 3.9 
                 4.2 
                 4.3 
                 2.9 
               
               
                 Liver Tissue 6005-N 
                 22.2 
                 24.5 
                 32.8 
                 27.5 
                 28.7 
               
               
                 Normal Bladder 
                 5.3 
                 3.4 
                 4.8 
                 4.2 
                 5.5 
               
               
                 Bladder Cancer 1023 
                 1.6 
                 1.3 
                 1.5 
                 1.6 
                 1.7 
               
               
                 Bladder Cancer A302173 
                 0.9 
                 0.4 
                 1.5 
                 1.0 
                 0.3 
               
               
                 Bladder Cancer (OD04718-01) 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Bladder Normal Adjacent (OD04718-03) 
                 5.2 
                 6.2 
                 7.8 
                 6.0 
                 4.1 
               
               
                 Normal Ovary 
                 1.6 
                 3.0 
                 5.4 
                 3.6 
                 3.6 
               
               
                 Ovarian Cancer 064008 
                 0.0 
                 0.1 
                 0.1 
                 0.6 
                 0.5 
               
               
                 Ovarian Cancer (OD04768-07) 
                 0.0 
                 0.0 
                 0.0 
                 0.1 
                 0.0 
               
               
                 Ovary Margin (OD04768-08) 
                 2.3 
                 1.7 
                 3.1 
                 2.4 
                 2.6 
               
               
                 Normal Stomach 
                 0.9 
                 0.8 
                 1.7 
                 0.8 
                 0.8 
               
               
                 Gastric Cancer 9060358 
                 0.0 
                 0.4 
                 0.8 
                 0.4 
                 0.2 
               
               
                 Stomach Margin 9060359 
                 1.2 
                 0.8 
                 1.3 
                 1.0 
                 0.9 
               
               
                 Gastric Cancer 9060395 
                 0.1 
                 0.2 
                 0.3 
                 0.5 
                 0.6 
               
               
                 Stomach Margin 9060394 
                 0.8 
                 0.6 
                 1.7 
                 0.7 
                 0.6 
               
               
                 Gastric Cancer 9060397 
                 0.1 
                 0.1 
                 0.1 
                 0.0 
                 0.0 
               
               
                 Stomach Margin 9060396 
                 0.3 
                 0.1 
                 0.6 
                 0.1 
                 0.3 
               
               
                 Gastric Cancer 064005 
                 0.7 
                 0.6 
                 0.4 
                 1.1 
                 0.3 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag2742, Run 153641758    
               
               
                   Column B - Rel. Exp. (%) Ag2743, Run 153658357    
               
               
                   Column C - Rel. Exp. (%) Ag2744, Run 153670751    
               
               
                   Column D - Rel. Exp. (%) Ag2745, Run 153664739    
               
               
                   Column E - Rel. Exp. (%) Ag2746, Run 153675220    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE HN 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
                 D 
                 E 
                 F 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Secondary Th1 act 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 act 
                 0.0 
                 0.7 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 act 
                 1.7 
                 0.0 
                 1.9 
                 0.0 
                 7.5 
                 2.8 
               
               
                 Secondary Th1 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 2.8 
               
               
                 Primary Th1 act 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th2 act 
                 1.6 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 4.8 
               
               
                 Primary Tr1 act 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th1 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th2 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CD45RA CD4 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CD45RO CD4 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CD8 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte act 
                 0.7 
                 0.0 
                 0.0 
                 7.8 
                 0.0 
                 1.8 
               
               
                 CD4 lymphocyte none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 4.7 
               
               
                 LAK cells IL-2 + IL-12 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 1.9 
                 0.0 
               
               
                 LAK cells IL-2 + IFN gamma 
                 0.0 
                 1.5 
                 3.3 
                 5.0 
                 0.0 
                 3.0 
               
               
                 LAK cells IL-2 + IL-18 
                 0.0 
                 0.0 
                 2.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 NK Cells IL-2 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 3 day 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 5 day 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 7 day 
                 2.0 
                 0.0 
                 6.4 
                 0.0 
                 0.0 
                 11.3 
               
               
                 PBMC rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 5.1 
               
               
                 PBMC PWM 
                 0.0 
                 2.3 
                 0.0 
                 0.0 
                 0.0 
                 2.7 
               
               
                 PBMC PHA-L 
                 0.0 
                 1.5 
                 2.5 
                 0.0 
                 0.0 
                 2.2 
               
               
                 Ramos (B cell) none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 B lymphocytes PWM 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 2.0 
               
               
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 6.0 
               
               
                 EOL-1 dbcAMP 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells none 
                 1.4 
                 2.9 
                 0.0 
                 0.0 
                 4.9 
                 0.0 
               
               
                 Dendritic cells LPS 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells anti-CD40 
                 0.0 
                 0.0 
                 3.3 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Monocytes rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Monocytes LPS 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Macrophages rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Macrophages LPS 
                 0.0 
                 0.0 
                 0.0 
                 2.4 
                 0.0 
                 0.0 
               
               
                 HUVEC none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC starved 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-1beta 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC IFN gamma 
                 3.7 
                 0.0 
                 0.0 
                 0.0 
                 2.7 
                 0.0 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IL4 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-11 
                 1.4 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 2.6 
               
               
                 Lung Microvascular EC none 
                 1.6 
                 0.0 
                 2.2 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 3.1 
                 2.9 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Microvascular Dermal EC none 
                 0.0 
                 3.1 
                 5.0 
                 0.0 
                 0.0 
                 12.6 
               
               
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 1.4 
                 1.1 
                 0.0 
                 0.0 
                 1.6 
                 0.0 
               
               
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Small airway epithelium none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Coronery artery SMC rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Astrocytes rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Astrocytes TNFalpha + IL-1 beta 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Liver cirrhosis 
                 100.0 
                 100.0 
                 100.0 
                 100.0 
                 100.0 
                 100.0 
               
               
                 Lupus kidney 
                 0.0 
                 1.4 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 NCI-H292 none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IL-4 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 2.3 
                 0.0 
               
               
                 NCI-H292 IL-9 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IL-13 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IFN gamma 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HPAEC none 
                 4.8 
                 1.4 
                 0.0 
                 0.0 
                 0.0 
                 3.0 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-4 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-9 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-13 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IFN gamma 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast IFN gamma 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 5.3 
               
               
                 Dermal fibroblast IL-4 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 IBD Colitis 2 
                 1.7 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 IBD Crohn&#39;s 
                 4.5 
                 1.6 
                 6.7 
                 6.1 
                 3.3 
                 3.0 
               
               
                 Colon 
                 5.5 
                 2.1 
                 23.0 
                 8.3 
                 4.7 
                 11.1 
               
               
                 Lung 
                 41.5 
                 26.2 
                 27.7 
                 39.2 
                 37.1 
                 49.7 
               
               
                 Thymus 
                 4.2 
                 0.0 
                 4.1 
                 0.0 
                 1.4 
                 20.6 
               
               
                 Kidney 
                 4.7 
                 5.2 
                 8.7 
                 5.9 
                 6.3 
                 6.7 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag2742, Run 153641803    
               
               
                   Column B - Rel. Exp. (%) Ag2743, Run 153658360    
               
               
                   Column C - Rel. Exp. (%) Ag2744, Run 153670759    
               
               
                   Column D - Rel. Exp. (%) Ag2745, Run 153664740    
               
               
                   Column E - Rel. Exp. (%) Ag2746, Run 153675321    
               
               
                   Column F - Rel. Exp. (%) Ag812, Run 138175358    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE HO 
               
             
            
               
                   
               
               
                   
               
               
                 general oncology screening panel_v_2.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Colon cancer 1 
                 2.9 
               
               
                   
                 Colon NAT 1 
                 3.9 
               
               
                   
                 Colon cancer 2 
                 10.2 
               
               
                   
                 Colon NAT 2 
                 5.0 
               
               
                   
                 Colon cancer 3 
                 4.8 
               
               
                   
                 Colon NAT 3 
                 10.2 
               
               
                   
                 Colon malignant cancer 4 
                 0.0 
               
               
                   
                 Colon NAT 4 
                 3.8 
               
               
                   
                 Lung cancer 1 
                 5.0 
               
               
                   
                 Lung NAT 1 
                 1.3 
               
               
                   
                 Lung cancer 2 
                 9.0 
               
               
                   
                 Lung NAT 2 
                 0.0 
               
               
                   
                 Squamous cell carcinoma 3 
                 6.1 
               
               
                   
                 Lung NAT 3 
                 0.0 
               
               
                   
                 Metastatic melanoma 1 
                 43.8 
               
               
                   
                 Melanoma 2 
                 0.5 
               
               
                   
                 Melanoma 3 
                 4.0 
               
               
                   
                 Metastatic melanoma 4 
                 82.4 
               
               
                   
                 Metastatic melanoma 5 
                 100.0 
               
               
                   
                 Bladder cancer 1 
                 1.8 
               
               
                   
                 Bladder NAT 1 
                 0.0 
               
               
                   
                 Bladder cancer 2 
                 0.7 
               
               
                   
                 Bladder NAT 2 
                 0.7 
               
               
                   
                 Bladder NAT 3 
                 0.0 
               
               
                   
                 Bladder NAT 4 
                 9.0 
               
               
                   
                 Prostate adenocarcinoma 1 
                 0.7 
               
               
                   
                 Prostate adenocarcinoma 2 
                 0.6 
               
               
                   
                 Prostate adenocarcinoma 3 
                 0.9 
               
               
                   
                 Prostate adenocarcinoma 4 
                 0.9 
               
               
                   
                 Prostate NAT 5 
                 2.3 
               
               
                   
                 Prostate adenocarcinoma 6 
                 0.0 
               
               
                   
                 Prostate adenocarcinoma 7 
                 0.0 
               
               
                   
                 Prostate adenocarcinoma 8 
                 1.0 
               
               
                   
                 Prostate adenocarcinoma 9 
                 0.7 
               
               
                   
                 Prostate NAT 10 
                 0.2 
               
               
                   
                 Kidney cancer 1 
                 1.1 
               
               
                   
                 Kidney NAT 1 
                 1.6 
               
               
                   
                 Kidney cancer 2 
                 16.2 
               
               
                   
                 Kidney NAT 2 
                 3.0 
               
               
                   
                 Kidney cancer 3 
                 4.7 
               
               
                   
                 Kidney NAT 3 
                 0.0 
               
               
                   
                 Kidney cancer 4 
                 0.0 
               
               
                   
                 Kidney NAT 4 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag812, Run 262228032    
               
            
           
         
       
     
      Panel 1 Summary: Ag03/Ag068 Highest expression of this gene was detected in the spleen (CTs=21-25). This gene was more highly expressed in normal tissue than in cancer cell lines. There were however detectable levels of expression in cell lines derived from melanoma, breast, renal, ovarian, lung, gastric and colon cancers. The difference in levels of expression of this gene is useful for differentiating between these cancer cell line samples and other samples on this panel and between normal tissues and malignancies from those cancers.  
      There were also higher levels of expression in lung, and kidney tissue from fetal sources (CTs=25-28) when compared to levels of expression in the adult (CTs=38-31). 10 Expression of this gene or its protein product is useful for differentiating between adult and fetal lung and kidney tissue.  
      Among tissues with metabolic function, this gene was expressed in the liver, pituitary, thyroid, heart, skeletal muscle and adrenal gland. This demonstrates that the protein encoded by this gene is involved in the homeostasis of these tissues. Therapeutic 15 modulation of the expression or function of this gene product is effective in the treatment of metabolic disorders, including obesity and diabetes.  
      This gene is a homolog of Stablin-1, and was also expressed at moderate levels in all brain regions examined. Because stablin is involved in angiogenesis, the therapeutic modulation of this gene or its protein product is of benefit in the treatment of 20 stroke/cerebral ischemia/cerebral infarct.  
      Panel 1.2 Summary: Ag812 Highest expression of this gene was detected in the liver (CTs=25). Significant expression was also found in other metabolic tissues including fetal and adult heart, skeletal muscle, pancreas, thyroid, pituitary and adrenal gland. The high expression of this gene in the liver shows that this gene is involved in the normal homeostasis of that organ. Therapeutic modulation of the expression or function of this gene or protein product is effective in the treatment of diseases that involve the liver.  
      This gene also showed low to moderate expression in the brain. Please see Panel 1 for discussion of potential utility of this gene in the central nervous system.  
      While this gene showed a greater association for normal tissue, there were significant levels of expression in a cluster of ovarian cancer cell lines. Expression of this gene is useful for differentiating between those samples and other samples on this panel, and between normal and malignant ovarian tissue. Therapeutic modulation of the expression or function of this gene or protein product is effective in the treatment of ovarian cancer.  
      Panel 1.3D Summary: Ag2742, Ag2743, Ag2744, Ag2745, Ag2746 Highest expression of this gene was detected in the liver (CTs=25). Significant expression was also found in the spleen (CTs=28-29). This result was in concordance with the results from Panel 1.  
      This gene was expressed at higher levels in the fetal kidney and skeletal muscle (CTs=32-34) than in the comparable adult tissues (CTs=40). Thus, expression of this gene is useful for differentiating between kidney and skeletal muscle tissue from adult and fetal sources. The higher levels of expression of this gene in the fetal tissues show that this gene product is involved in the development of these organs. Therapeutic modulation of the expression or function of these genes or their protein products is effective in treating disease of these organs in the adult.  
      In this panel, expression this gene was exclusively associate with normal tissue samples, a preference that was also observed in panels 1 and 1.2. Absence of expression of this gene is useful in differentiating between the cancerous cell lines on this panel, and their corresponding normal tissues.  
      Panel 2D Summary: Ag2742/Ag2743/Ag2744/Ag2745/Ag2746 Expression of this gene was highest and almost exclusive in the liver (CTs=27-29). This result was in concordance with the results from previous panels. The low/undetectable levels of expression in cancer samples was also in agreement with the results observed in the preceding experiments. Expression of this gene or its protein product is useful for differentiating between liver tissue and other samples on this panel and as a marker for liver tissue. Therapeutic modulation of the expression or function of the gene or the protein encoded by this gene is effective in the treatment of liver cancer or other disease that involve the liver. This gene is useful as a marker for breast cancer metastasis as it shows elevated expression in a metastatic breast cancer compared to expression in the primary cancer.  
      Panel 4D Summary: Ag812/Ag2742/Ag2743/Ag2744/Ag2745/Ag2746 The expression of this gene appears was highest in samples from cirrhotic liver, (CTs=32-33). Low level expression was also detected in samples derived from normal lung. The presence of this gene in liver cirrhosis (a component of which involves liver inflammation and fibrosis) shows that therapeutic agents involving this gene or its protein product are useful in reducing or inhibiting the inflammation associated with fibrotic and other inflammatory diseases.  
      general oncology screening panel_V — 2.4 Summary: Ag812 Highest expression of this gene was seen in metastatic melanoma (CTs=31). Gene, protein, antibodies or small molecule therapeutics that target this gene or its protein product are useful in the treatment of melanoma.  
      I. CG50925-01 and CG50925-02: TENM5  
      Expression of gene CG50925-01 and variant CG50925-02 was assessed using the primer-probe set Ag1402 described in Table IA. Results of the RTQ-PCR runs are shown in Tables B, IC, ID, IE, IF, IG, and IH.  
               TABLE IA                          Probe Name Ag1402                                                 Start   SEQ ID           Primers   Sequences   Length   Position   No                                             Forward   5′-cttacaacaccacgggactaag-3′   22   5546   1291                   Probe   TET-5′-aagagcacttccttgcctccgtaagg-3′-   26   5569   1292           TAMRA               Reverse   5′-agatcaaatgattgggatggtt-3′   22   5605   1293                  
 
     
       
         
           
               
             
               
                 TABLE IB 
               
             
            
               
                   
               
               
                   
               
               
                 HASS Panel v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 MCF-7 C1 
                 2.4 
               
               
                   
                 MCF-7 C2 
                 4.2 
               
               
                   
                 MCF-7 C3 
                 3.6 
               
               
                   
                 MCF-7 C4 
                 4.9 
               
               
                   
                 MCF-7 C5 
                 4.2 
               
               
                   
                 MCF-7 C6 
                 5.2 
               
               
                   
                 MCF-7 C7 
                 3.3 
               
               
                   
                 MCF-7 C9 
                 3.4 
               
               
                   
                 MCF-7 C10 
                 6.7 
               
               
                   
                 MCF-7 C11 
                 0.9 
               
               
                   
                 MCF-7 C12 
                 5.2 
               
               
                   
                 MCF-7 C13 
                 1.6 
               
               
                   
                 MCF-7 C15 
                 2.6 
               
               
                   
                 MCF-7 C16 
                 6.3 
               
               
                   
                 MCF-7 C17 
                 7.5 
               
               
                   
                 T24 D1 
                 0.5 
               
               
                   
                 T24 D2 
                 2.0 
               
               
                   
                 T24 D3 
                 2.0 
               
               
                   
                 T24 D4 
                 1.8 
               
               
                   
                 T24 D5 
                 2.5 
               
               
                   
                 T24 D6 
                 2.4 
               
               
                   
                 T24 D7 
                 1.1 
               
               
                   
                 T24 D9 
                 6.6 
               
               
                   
                 T24 D10 
                 2.2 
               
               
                   
                 T24 D11 
                 2.2 
               
               
                   
                 T24 D12 
                 3.1 
               
               
                   
                 T24 D13 
                 2.0 
               
               
                   
                 T24 D15 
                 6.2 
               
               
                   
                 T24 D16 
                 1.1 
               
               
                   
                 T24 D17 
                 1.7 
               
               
                   
                 CAPaN B1 
                 2.3 
               
               
                   
                 CAPaN B2 
                 0.7 
               
               
                   
                 CAPaN B3 
                 0.3 
               
               
                   
                 CAPaN B4 
                 0.3 
               
               
                   
                 CAPaN B5 
                 1.2 
               
               
                   
                 CAPaN B6 
                 1.1 
               
               
                   
                 CAPaN B7 
                 0.4 
               
               
                   
                 CAPaN B8 
                 0.5 
               
               
                   
                 CAPaN B9 
                 0.8 
               
               
                   
                 CAPaN B10 
                 0.9 
               
               
                   
                 CAPaN B11 
                 0.8 
               
               
                   
                 CAPaN B12 
                 0.6 
               
               
                   
                 CAPaN B13 
                 0.7 
               
               
                   
                 CAPaN B14 
                 1.4 
               
               
                   
                 CAPaN B15 
                 0.4 
               
               
                   
                 CAPaN B16 
                 0.6 
               
               
                   
                 CAPaN B17 
                 1.2 
               
               
                   
                 U87-MG F1 (B) 
                 1.0 
               
               
                   
                 U87-MG F2 
                 2.7 
               
               
                   
                 U87-MG F3 
                 5.6 
               
               
                   
                 U87-MG F4 
                 2.9 
               
               
                   
                 U87-MG F5 
                 6.7 
               
               
                   
                 U87-MG F6 
                 7.3 
               
               
                   
                 U87-MG F7 
                 4.5 
               
               
                   
                 U87-MG F8 
                 11.7 
               
               
                   
                 U87-MG F9 
                 3.4 
               
               
                   
                 U87-MG F10 
                 5.0 
               
               
                   
                 U87-MG F11 
                 12.9 
               
               
                   
                 U87-MG F12 
                 7.9 
               
               
                   
                 U87-MG F13 
                 9.7 
               
               
                   
                 U87-MG F14 
                 24.3 
               
               
                   
                 U87-MG F15 
                 10.7 
               
               
                   
                 U87-MG F16 
                 6.8 
               
               
                   
                 U87-MG F17 
                 11.4 
               
               
                   
                 LnCAP A1 
                 0.9 
               
               
                   
                 LnCAP A2 
                 2.0 
               
               
                   
                 LnCAP A3 
                 2.2 
               
               
                   
                 LnCAP A4 
                 2.5 
               
               
                   
                 LnCAP A5 
                 2.0 
               
               
                   
                 LnCAP A6 
                 1.8 
               
               
                   
                 LnCAP A7 
                 5.3 
               
               
                   
                 LnCAP A8 
                 5.3 
               
               
                   
                 LnCAP A9 
                 3.0 
               
               
                   
                 LnCAP A10 
                 1.8 
               
               
                   
                 LnCAP A11 
                 6.2 
               
               
                   
                 LnCAP A12 
                 0.5 
               
               
                   
                 LnCAP A13 
                 0.5 
               
               
                   
                 LnCAP A14 
                 0.8 
               
               
                   
                 LnCAP A15 
                 0.8 
               
               
                   
                 LnCAP A16 
                 1.7 
               
               
                   
                 LnCAP A17 
                 4.6 
               
               
                   
                 Primary Astrocytes 
                 27.0 
               
               
                   
                 Primary Renal Proximal Tubule Epithelial cell A2 
                 0.8 
               
               
                   
                 Primary melanocytes A5 
                 100.0 
               
               
                   
                 126443 - 341 medullo 
                 0.6 
               
               
                   
                 126444 - 487 medullo 
                 28.1 
               
               
                   
                 126445 - 425 medullo 
                 1.2 
               
               
                   
                 126446 - 690 medullo 
                 8.8 
               
               
                   
                 126447 - 54 adult glioma 
                 28.1 
               
               
                   
                 126448 - 245 adult glioma 
                 76.3 
               
               
                   
                 126449 - 317 adult glioma 
                 9.5 
               
               
                   
                 126450 - 212 glioma 
                 5.9 
               
               
                   
                 126451 - 456 glioma 
                 27.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1402, Run 318641615    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE IC 
               
             
            
               
                   
               
               
                   
               
               
                 Human Metabolic 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 137857_psoas-AA.M.Diab.-hi BMI-6 
                 0.5 
               
               
                   
                 135760_psoas-HI.M.Diab.-hi BMI-21 
                 1.4 
               
               
                   
                 134827_psoas-CC.M.Diab.-hi BMI-4 
                 2.1 
               
               
                   
                 137860_psoas-AA.M.Diab.-med BMI-8 
                 1.1 
               
               
                   
                 137834_psoas-CC.M.Diab.-med BMI-2 
                 2.8 
               
               
                   
                 137828_psoas-CC.M.Diab.-med BMI-1 
                 2.1 
               
               
                   
                 135763_psoas-HI.M.Diab.-med BMI-23 
                 1.2 
               
               
                   
                 142740_psoas-AS.M.Diab.-low BMI-20 
                 18.4 
               
               
                   
                 134834_psoas-AA.M.Diab.-low BMI-17 
                 1.2 
               
               
                   
                 137850_psoas-AS.M.Norm-hi BMI-34 
                 1.8 
               
               
                   
                 135769_psoas-HI.M.Norm-hi BMI-31 
                 0.6 
               
               
                   
                 135766_psoas-AA.M.Norm-hi BMI-25 
                 1.3 
               
               
                   
                 142746_psoas-AA.M.Norm-med BMI-37 
                 38.2 
               
               
                   
                 142745_psoas-HI.M.Norm-med BMI-35 
                 15.7 
               
               
                   
                 137855_psoas-AA.M.Norm-med BMI-47 
                 0.9 
               
               
                   
                 137844_psoas-CC.M.Norm-med BMI-26 
                 0.5 
               
               
                   
                 142742_psoas-CC.M.Norm-low BMI-40 
                 29.9 
               
               
                   
                 137873_psoas-AS.M.Norm-low BMI-28 
                 0.6 
               
               
                   
                 137853_psoas-HI.M.Norm-low BMI-41 
                 0.9 
               
               
                   
                 135775_psoas-CC.M.Norm-low BMI-39 
                 0.5 
               
               
                   
                 137858_diaphragm-AA.M.Diab.-hi BMI-6 
                 1.6 
               
               
                   
                 135772_diaphragm-AS.M.Diab-hi BMI-9 
                 2.1 
               
               
                   
                 135761_diaphragm-HI.M.Diab.-hi BMI-21 
                 5.9 
               
               
                   
                 134828_diaphragm-CC.M.Diab.-hi BMI-4 
                 1.1 
               
               
                   
                 137835_diaphragm-CC.M.Diab.-med BMI-2 
                 1.6 
               
               
                   
                 135764_diaphragm-HI.M.Diab.-med BMI-23 
                 1.8 
               
               
                   
                 134835_diaphragm-AA.M.Diab.-low BMI-17 
                 1.8 
               
               
                   
                 142738_diaphragm-CC.M.Norm-hi BMI-29 
                 2.1 
               
               
                   
                 139517_diaphragm-AS.M.Norm-hi BMI-34 
                 3.3 
               
               
                   
                 137848_diaphragm-HI.M.Norm-hi BMI-31 
                 0.9 
               
               
                   
                 137843_diaphragm-AA.M.Norm-hi BMI-25 
                 1.7 
               
               
                   
                 137879_diaphragm-AA.M.Norm-med BMI-47 
                 1.7 
               
               
                   
                 137872_diaphragm-CC.M.Norm-med BMI-26 
                 1.2 
               
               
                   
                 135773_diaphragm-HI.M.Norm-med BMI-35 
                 51.1 
               
               
                   
                 139542_diaphragm-HI.M.Norm-low BMI-41 
                 1.9 
               
               
                   
                 137877_diaphragm-CC.M.Norm-low BMI-39 
                 1.2 
               
               
                   
                 137874_diaphragm-AS.M.Norm-low BMI-28 
                 0.9 
               
               
                   
                 141340_subQadipose-AA.M.Diab.-hi BMI-6 
                 15.8 
               
               
                   
                 137836_subQadipose-HI.M.Diab.-hi BMI-21 
                 2.1 
               
               
                   
                 135771_subQadipose-AS.M.Diab-hi BMI-9 
                 4.0 
               
               
                   
                 141329_subQadipose-AA.M.Diab-medbmi-8 
                 3.1 
               
               
                   
                 137862_subQadipose-CC.M.Diab.-med BMI-1 
                 3.8 
               
               
                   
                 135762_subQadipose-HI.M.Diab.-med BMI-23 
                 1.1 
               
               
                   
                 141338_subQadipose-AS.M.Diab.-low BMI-20 
                 1.4 
               
               
                   
                 139547_subQadipose-HI.M.Diab.-low BMI-22 
                 4.4 
               
               
                   
                 135757_subQadipose-CC.M.Diab.-low BMI-13 
                 2.4 
               
               
                   
                 134832_subQadipose-AA.M.Diab.-low BMI-17 
                 2.8 
               
               
                   
                 141332_subQadipose-HI.M.Norm-hi BMI-31 
                 4.0 
               
               
                   
                 135767_subQadipose-CC.M.Norm-hi BMI-29 
                 0.4 
               
               
                   
                 135765_subQadipose-AS.M.Norm-hi BMI-34 
                 0.9 
               
               
                   
                 141339_subQadipose-HI.M.Norm-med BMI-35 
                 6.0 
               
               
                   
                 141334_subQadipose-CC.M.Norm-med BMI-26 
                 1.5 
               
               
                   
                 139544_subQadipose-AA.M.Norm-med BMI-47 
                 3.3 
               
               
                   
                 137875_subQadipose-AA.M.Norm-med BMI-37 
                 1.9 
               
               
                   
                 141331_subQadipose-AS.M.Norm-low BMI-28 
                 2.1 
               
               
                   
                 137878_subQadipose-HI.M.Norm-low BMI-41 
                 2.2 
               
               
                   
                 137876_subQadipose-CC.M.Norm-low BMI-39 
                 2.1 
               
               
                   
                 137859_vis.adipose-AA.M.Diab.-hi BMI-6 
                 0.7 
               
               
                   
                 135770_vis.adipose-AS.M.Diab-hi BMI-9 
                 5.6 
               
               
                   
                 135759_vis.adipose-HI.M.Diab.-hi BMI-21 
                 0.9 
               
               
                   
                 143502_vis.adipose-CC.M.Diab.-med BMI-2 
                 9.8 
               
               
                   
                 139510_vis.adipose-AA.M.Diab.-med BMI-8 
                 1.4 
               
               
                   
                 137861_vis.adipose-CC.M.Diab.-med-1 
                 2.2 
               
               
                   
                 137839_vis.adipose-HI.M.Diab.-med BMI-23 
                 1.5 
               
               
                   
                 139546_vis.adipose-HI.M.Diab.-low BMI-22 
                 7.3 
               
               
                   
                 137831_vis.adipose-CC.M.Diab.-low BMI-13 
                 1.6 
               
               
                   
                 139522_vis.adipose-HI.M.Norm-hi BMI-31 
                 2.7 
               
               
                   
                 139516_vis.adipose-AS.M.Norm-hi BMI-34 
                 33.9 
               
               
                   
                 137846_vis.adipose-CC.M.Norm-hi BMI-29 
                 0.2 
               
               
                   
                 137841_vis.adipose-AA.M.Norm-hi BMI-25 
                 0.7 
               
               
                   
                 139543_vis.adipose-AA.M.Norm-med BMI-47 
                 20.2 
               
               
                   
                 139532_vis.adipose-AA.M.Norm-med BMI-37 
                 2.2 
               
               
                   
                 139530_vis.adipose-HI.M.Norm-med BMI-35 
                 1.5 
               
               
                   
                 139539_vis.adipose-HI.M.Norm-low BMI-41 
                 2.0 
               
               
                   
                 139535_vis.adipose-CC.M.Norm-low BMI-40 
                 13.1 
               
               
                   
                 137852_vis.adipose-CC.M.Norm-low BMI-39 
                 2.8 
               
               
                   
                 135768_vis.adipose-AS.M.Norm-low BMI-28 
                 0.5 
               
               
                   
                 141327_liver-CC.M.Diab.-hi BMI-4 
                 1.1 
               
               
                   
                 139514_liver-HI.M.Diab.-hi BMI-21 
                 2.0 
               
               
                   
                 139526_liver-CC.M.Diab.-med BMI-2 
                 2.2 
               
               
                   
                 139511_liver-AA.M.Diab.-med BMI-8 
                 2.0 
               
               
                   
                 137840_liver-HI.M.Diab.-med BMI-23 
                 1.1 
               
               
                   
                 137827_liver-CC.M.Diab.-med BMI-1 
                 0.8 
               
               
                   
                 137838_liver-HI.M.Diab.-low BMI-22 
                 0.4 
               
               
                   
                 135758_liver-CC.M.Diab.-low BMI-13 
                 0.6 
               
               
                   
                 139519_liver-CC.M.Norm-hi BMI-29 
                 1.9 
               
               
                   
                 139518_liver-AA.M.Norm-hi BMI-25 
                 1.9 
               
               
                   
                 137849_liver-AS.M.Norm-hi BMI-34 
                 1.1 
               
               
                   
                 137847_liver-HI.M.Norm-hi BMI-31 
                 0.5 
               
               
                   
                 142741_liver-AA.M.Norm-med BMI-37 
                 1.8 
               
               
                   
                 141341_liver-HI.M.Norm-med BMI-35 
                 1.1 
               
               
                   
                 141335_liver-CC.M.Norm-med BMI-26 
                 1.3 
               
               
                   
                 139540_liver-HI.M.Norm-low BMI-41 
                 7.1 
               
               
                   
                 139534_liver-CC.M.Norm-low BMI-39 
                 5.8 
               
               
                   
                 139521_liver-AS.M.Norm-low BMI-28 
                 0.8 
               
               
                   
                 141328_pancreas-CC.M.Diab.-hi BMI-4 
                 28.9 
               
               
                   
                 139525_pancreas-AS.M.Diab.-hi BMI-9 
                 5.1 
               
               
                   
                 137856_pancreas-AA.M.Diab.-hi BMI-6 
                 0.3 
               
               
                   
                 137837_pancreas-HI.M.Diab.-hi BMI-21 
                 1.3 
               
               
                   
                 141337_pancreas-CC.M.Diab.-med BMI-2 
                 4.4 
               
               
                   
                 139527_pancreas-CC.M.Diab.-med BMI-1 
                 7.9 
               
               
                   
                 139515_pancreas-HI.M.Diab.-med BMI-23 
                 27.0 
               
               
                   
                 139512_pancreas-AA.M.Diab.-med BMI-8 
                 40.3 
               
               
                   
                 142739_pancreas-AS.M.Diab.-low BMI-20 
                 25.9 
               
               
                   
                 139513_pancreas-CC.M.Diab.-low BMI-13 
                 16.8 
               
               
                   
                 142743_pancreas-AA.M.Norm-hi BMI-25 
                 11.0 
               
               
                   
                 139523_pancreas-HI.M.Norm-hi BMI-31 
                 16.7 
               
               
                   
                 139520_pancreas-CC.M.Norm-hi BMI-29 
                 27.9 
               
               
                   
                 142744_pancreas-HI.M.Norm-med BMI-35 
                 3.4 
               
               
                   
                 139545_pancreas-AA.M.Norm-med BMI-47 
                 27.9 
               
               
                   
                 139531_pancreas-AA.M.Norm-med BMI-37 
                 8.1 
               
               
                   
                 137871_pancreas-CC.M.Norm-med BMI-26 
                 1.3 
               
               
                   
                 139541_pancreas-Hi.M.Norm-low BMI-41 
                 16.5 
               
               
                   
                 139537_pancreas-CC.M.Norm-low BMI-40 
                 14.7 
               
               
                   
                 139533_pancreas-CC.M.Norm-low BMI-39 
                 2.8 
               
               
                   
                 137845_pancreas-AS.M.Norm-low BMI-28 
                 0.9 
               
               
                   
                 143530_small intestine-AA.M.Diab.-hi BMI-6 
                 7.7 
               
               
                   
                 143529_small intestine-CC.M.Diab.-hi BMI-4 
                 35.1 
               
               
                   
                 143538_small intestine-HI.M.Diab.-med BMI-23 
                 55.1 
               
               
                   
                 143531_small intestine-AA.M.Diab.-med BMI-8 
                 44.1 
               
               
                   
                 143528_small intestine-CC.M.Diab.-med BMI-2 
                 28.7 
               
               
                   
                 143537_small intestine-HI.M.Diab.-low BMI-22 
                 17.6 
               
               
                   
                 143535_small intestine-AS.M.Diab.-low BMI-20 
                 16.7 
               
               
                   
                 143534_small intestine-AA.M.Diab.-low BMI-17 
                 0.8 
               
               
                   
                 143544_small intestine-AS.M.Norm-hi BMI-34 
                 16.8 
               
               
                   
                 143543_small intestine-HI.M.Norm-hi BMI-31 
                 3.7 
               
               
                   
                 143542_small intestine-CC.M.Norm-hi BMI-29 
                 10.3 
               
               
                   
                 143539_small intestine-AA.M.Norm-hi BMI-25 
                 31.9 
               
               
                   
                 143548_small intestine-AA.M.Norm-med BMI-47 
                 0.0 
               
               
                   
                 143547_small intestine-AA.M.Norm-med BMI-37 
                 24.5 
               
               
                   
                 143540_small intestine-CC.M.Norm-med BMI-26 
                 3.9 
               
               
                   
                 143550_small intestine-CC.M.Norm-low BMI-40 
                 1.4 
               
               
                   
                 143549_small intestine-CC.M.Norm-low BMI-39 
                 24.0 
               
               
                   
                 143546_small intestine-HI.M.Norm-low BMI-41 
                 4.7 
               
               
                   
                 143525_hypothalamus-HI.M.Diab.-hi BMI-21 
                 22.8 
               
               
                   
                 143515_hypothalamus-CC.M.Diab.-hi BMI-4 
                 8.4 
               
               
                   
                 143513_hypothalamus-AA.M.Diab.-hi BMI-6 
                 1.5 
               
               
                   
                 143507_hypothalamus-AS.M.Diab.-hi BMI-9 
                 1.8 
               
               
                   
                 143506_hypothalamus-CC.M.Diab.-med BMI-1 
                 3.9 
               
               
                   
                 143505_hypothalamus-HI.M.Diab.-med BMI-23 
                 31.0 
               
               
                   
                 143509_hypothalamus-AA.M.Diab.-low BMI-17 
                 2.6 
               
               
                   
                 143508_hypothalamus-CC.M.Diab.-low BMI-13 
                 2.4 
               
               
                   
                 143503_hypothalamus-AS.M.Diab.-low BMI-20 
                 2.7 
               
               
                   
                 143522_hypothalamus-HI.M.Norm-hi BMI-31 
                 1.5 
               
               
                   
                 143516_hypothalamus-AS.M.Norm-hi BMI-34 
                 1.1 
               
               
                   
                 143511_hypothalamus-CC.M.Norm-hi BMI-29 
                 2.4 
               
               
                   
                 143504_hypothalamus-AA.M.Norm-hi BMI-25 
                 1.6 
               
               
                   
                 143517_hypothalamus-AA.M.Norm-med BMI-47 
                 12.9 
               
               
                   
                 143514_hypothalamus-HI.M.Norm-med BMI-35 
                 1.0 
               
               
                   
                 143521_hypothalamus-AS.M.Norm-low BMI-28 
                 11.0 
               
               
                   
                 143512_hypothalamus-CC.M.Norm-low BMI-40 
                 10.3 
               
               
                   
                 145454_Patient-25pl (CC.Diab.low BMI.no insulin) 
                 29.1 
               
               
                   
                 110916_Patient-18pl (HI.Diab.obese.no insulin) 
                 11.5 
               
               
                   
                 110913_Patient-18go (HI.Diab.obese.no insulin) 
                 15.7 
               
               
                   
                 110911_Patient-17pl (CC.Diab.low BMI.no insulin) 
                 6.7 
               
               
                   
                 110908_Patient-17go (CC.Diab.low BMI.no insulin) 
                 14.0 
               
               
                   
                 100752_Patient-15sk (CC.Diab.obese.no insulin) 
                 5.9 
               
               
                   
                 97828_Patient-13pl (CC.Diab.overwt.no insulin) 
                 16.6 
               
               
                   
                 160114_Patient 27-ut (CC.Diab.obese.insulin) 
                 34.4 
               
               
                   
                 160113_Patient 27-pl (CC.Diab.obese.insulin) 
                 20.2 
               
               
                   
                 160112_Patient 27-sk (CC.Diab.obese.insulin) 
                 2.9 
               
               
                   
                 160111_Patient 27-go (CC.Diab.obese.insulin) 
                 11.7 
               
               
                   
                 145461_Patient-26sk (CC.Diab.obese.insulin) 
                 4.8 
               
               
                   
                 145441_Patient-22sk (CC.Diab.low BMI.insulin) 
                 3.3 
               
               
                   
                 145438_Patient-22pl (CC.Diab.low BMI.insulin) 
                 30.6 
               
               
                   
                 145427_Patient-20pl (CC.Diab.overwt.insulin) 
                 46.7 
               
               
                   
                 97503_Patient-12pl (CC.Diab.unknown 
                 2.2 
               
               
                   
                 BMI.insulin) 
               
               
                   
                 145443_Patient-23pl (CC.Non-diab.overwt) 
                 34.9 
               
               
                   
                 145435_Patient-21pl (CC.Non-diab.overwt) 
                 42.0 
               
               
                   
                 110921_Patient-19pl (CC.Non-diab.low BMI) 
                 16.3 
               
               
                   
                 110918_Patient-19go (CC.Non-diab.low BMI) 
                 8.5 
               
               
                   
                 97481_Patient-08sk (CC.Non-diab.obese) 
                 10.4 
               
               
                   
                 97478_Patient-07pl (CC.Non-diab.obese) 
                 9.2 
               
               
                   
                 160117_Human Islets-male, obese 
                 0.9 
               
               
                   
                 145474_PANC1 (pancreas carcinoma) 1 
                 1.5 
               
               
                   
                 154911_Capan2 (pancreas adenocarcinoma) 
                 1.2 
               
               
                   
                 141190_SW579 (thyroid carcinoma) 
                 25.3 
               
               
                   
                 145489_SK-N-MC (neuroblastoma) 1 
                 75.8 
               
               
                   
                 145495_SK-N-SH (neuroblastoma) 1 
                 34.4 
               
               
                   
                 145498_U87 MG (glioblastoma) 2 
                 1.4 
               
               
                   
                 145484_HEp-2 (larynx carcinoma) 1 
                 2.6 
               
               
                   
                 145479_A549 (lung carcinoma) 
                 3.3 
               
               
                   
                 145488_A427 (lung carcinoma) 2 
                 2.4 
               
               
                   
                 145472_FHs 738Lu (normal lung) 1 
                 59.0 
               
               
                   
                 141187_SKW6.4 (B lymphocytes) 
                 0.5 
               
               
                   
                 154644_IM-9 (immunoglobulin secreting 
                 0.3 
               
               
                   
                 lymphoblast) 
               
               
                   
                 154645_MOLT-4 (acute lymphoblastic leukemia 
                 1.3 
               
               
                   
                 derived from peripheral blood) 
               
               
                   
                 154648_U-937 (histiocystic lymphoma) 
                 100.0 
               
               
                   
                 154647_Daudi (Burkitt&#39;s lymphoma) 
                 0.6 
               
               
                   
                 145494_SK-MEL-2 (melanoma) 2 
                 11.7 
               
               
                   
                 141176_A375 (melanoma) 
                 2.9 
               
               
                   
                 154642_SW 1353 (humerus chondrosarcoma) 
                 13.8 
               
               
                   
                 141179_HT-1080 (fibrosarcoma) 
                 4.3 
               
               
                   
                 145491_MG-63 (osteosarcoma) 1 
                 35.4 
               
               
                   
                 141186_MCF7 (breast carcinoma) 
                 5.3 
               
               
                   
                 141193_T47D (breast carcinoma) 
                 1.9 
               
               
                   
                 154641_BT-20 (breast carcinoma) 
                 0.8 
               
               
                   
                 141175_293 (kidney transformed with adenovirus 
                 1.3 
               
               
                   
                 5 DNA) 
               
               
                   
                 141182_HUH hepatoma 1 
                 2.4 
               
               
                   
                 141184_HUH7 hepatoma 1 
                 3.2 
               
               
                   
                 145478_HT1376 (bladder carcinoma) 
                 0.3 
               
               
                   
                 145481_SCaBER (bladder carcinoma) 
                 1.0 
               
               
                   
                 141192_SW620 (lymph node metastatsis, colon 
                 1.8 
               
               
                   
                 carcinoma) 2 
               
               
                   
                 141180_HT29 (colon carcinoma) 1 
                 0.5 
               
               
                   
                 141188_SW480 (colon carcinoma) 1 
                 0.9 
               
               
                   
                 154646_CAOV-3 (ovary adenocarcinoma) 
                 1.0 
               
               
                   
                 141194_HeLa (cervix carcinoma)- 2 
                 2.2 
               
               
                   
                 145482_HeLa S3 (cervix carcinoma) 1 
                 1.4 
               
               
                   
                 145486_DU145 (prostate carcinoma) 
                 1.1 
               
               
                   
                 154643_PC-3 (prostate adenocarcinoma) 
                 2.0 
               
               
                   
                 154649_HCT-8 (ileocecal adenocarcinoma) 
                 5.9 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1402, Run 390904156    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ID 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.2 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Endothelial cells 
                 15.3 
                 15.8 
               
               
                   
                 Heart (Fetal) 
                 45.4 
                 33.9 
               
               
                   
                 Pancreas 
                 1.3 
                 0.5 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.2 
                 0.5 
               
               
                   
                 Adrenal Gland 
                 22.2 
                 17.7 
               
               
                   
                 Thyroid 
                 1.5 
                 0.5 
               
               
                   
                 Salivary gland 
                 12.0 
                 10.4 
               
               
                   
                 Pituitary gland 
                 1.7 
                 2.5 
               
               
                   
                 Brain (fetal) 
                 0.2 
                 0.3 
               
               
                   
                 Brain (whole) 
                 1.3 
                 1.6 
               
               
                   
                 Brain (amygdala) 
                 3.0 
                 3.0 
               
               
                   
                 Brain (cerebellum) 
                 2.8 
                 0.8 
               
               
                   
                 Brain (hippocampus) 
                 9.5 
                 9.5 
               
               
                   
                 Brain (thalamus) 
                 5.8 
                 5.6 
               
               
                   
                 Cerebral Cortex 
                 15.4 
                 12.3 
               
               
                   
                 Spinal cord 
                 1.5 
                 1.1 
               
               
                   
                 glio/astro U87-MG 
                 1.2 
                 1.4 
               
               
                   
                 glio/astro U-118-MG 
                 6.7 
                 7.7 
               
               
                   
                 astrocytoma SW1783 
                 1.8 
                 2.3 
               
               
                   
                 neuro*; met SK-N-AS 
                 32.1 
                 18.9 
               
               
                   
                 astrocytoma SF-539 
                 43.5 
                 30.4 
               
               
                   
                 astrocytoma SNB-75 
                 2.9 
                 2.7 
               
               
                   
                 glioma SNB-19 
                 1.7 
                 1.1 
               
               
                   
                 glioma U251 
                 7.0 
                 5.8 
               
               
                   
                 glioma SF-295 
                 24.8 
                 19.5 
               
               
                   
                 Heart 
                 100.0 
                 100.0 
               
               
                   
                 Skeletal Muscle 
                 19.6 
                 16.4 
               
               
                   
                 Bone marrow 
                 1.7 
                 2.2 
               
               
                   
                 Thymus 
                 1.6 
                 0.9 
               
               
                   
                 Spleen 
                 10.2 
                 7.6 
               
               
                   
                 Lymph node 
                 1.4 
                 1.3 
               
               
                   
                 Colorectal Tissue 
                 1.6 
                 4.2 
               
               
                   
                 Stomach 
                 5.1 
                 4.7 
               
               
                   
                 Small intestine 
                 40.1 
                 35.6 
               
               
                   
                 Colon ca. SW480 
                 1.2 
                 0.5 
               
               
                   
                 Colon ca.* SW620 (SW480 met) 
                 3.1 
                 2.0 
               
               
                   
                 Colon ca. HT29 
                 0.2 
                 0.2 
               
               
                   
                 Colon ca. HCT-116 
                 5.6 
                 3.0 
               
               
                   
                 Colon ca. CaCo-2 
                 1.7 
                 0.9 
               
               
                   
                 Colon ca. Tissue (ODO3866) 
                 2.2 
                 2.3 
               
               
                   
                 Colon ca. HCC-2998 
                 8.7 
                 4.6 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 1.2 
                 1.3 
               
               
                   
                 Bladder 
                 20.9 
                 18.6 
               
               
                   
                 Trachea 
                 1.4 
                 0.8 
               
               
                   
                 Kidney 
                 27.5 
                 30.6 
               
               
                   
                 Kidney (fetal) 
                 46.3 
                 13.7 
               
               
                   
                 Renal ca. 786-0 
                 0.5 
                 0.4 
               
               
                   
                 Renal ca. A498 
                 1.6 
                 1.4 
               
               
                   
                 Renal ca. RXF 393 
                 2.5 
                 2.3 
               
               
                   
                 Renal ca. ACHN 
                 1.7 
                 2.1 
               
               
                   
                 Renal ca. UO-31 
                 1.6 
                 1.1 
               
               
                   
                 Renal ca. TK-10 
                 3.3 
                 3.3 
               
               
                   
                 Liver 
                 13.2 
                 12.2 
               
               
                   
                 Liver (fetal) 
                 8.3 
                 6.2 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 2.5 
                 0.8 
               
               
                   
                 Lung 
                 1.5 
                 1.4 
               
               
                   
                 Lung (fetal) 
                 12.2 
                 5.4 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 3.3 
                 1.9 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 3.2 
                 2.7 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.9 
                 0.5 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 2.8 
                 2.1 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 3.1 
                 1.5 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 2.3 
                 3.4 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 5.3 
                 11.7 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 11.3 
                 9.3 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 1.2 
                 1.1 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 2.0 
                 2.0 
               
               
                   
                 Mammary gland 
                 4.2 
                 29.5 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.6 
                 0.7 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.3 
                 0.2 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 3.5 
                 2.5 
               
               
                   
                 Breast ca. BT-549 
                 0.4 
                 0.4 
               
               
                   
                 Breast ca. MDA-N 
                 12.2 
                 14.2 
               
               
                   
                 Ovary 
                 79.6 
                 54.3 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 1.0 
                 0.8 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 1.8 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 7.6 
                 4.5 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 20.4 
                 12.2 
               
               
                   
                 Ovarian ca. IGROV-1 
                 1.4 
                 1.1 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 14.4 
                 11.2 
               
               
                   
                 Uterus 
                 34.4 
                 19.6 
               
               
                   
                 Placenta 
                 6.7 
                 4.8 
               
               
                   
                 Prostate 
                 70.2 
                 74.2 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 7.9 
                 8.5 
               
               
                   
                 Testis 
                 1.2 
                 0.6 
               
               
                   
                 Melanoma Hs688(A).T 
                 15.8 
                 15.3 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 33.0 
                 26.6 
               
               
                   
                 Melanoma UACC-62 
                 9.9 
                 8.8 
               
               
                   
                 Melanoma M14 
                 3.3 
                 2.9 
               
               
                   
                 Melanoma LOX IMVI 
                 0.8 
                 1.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 5.8 
                 6.1 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1402, Run 138249713    
               
               
                   
                   Column B - Rel. Exp. (%) Ag1402, Run 138253129    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE IE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2.2 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 29.9 
               
               
                   
                 Colon cancer (OD06064) 
                 41.2 
               
               
                   
                 Colon Margin (OD06064) 
                 34.2 
               
               
                   
                 Colon cancer (OD06159) 
                 2.6 
               
               
                   
                 Colon Margin (OD06159) 
                 30.1 
               
               
                   
                 Colon cancer (OD06297-04) 
                 7.0 
               
               
                   
                 Colon Margin (OD06297-05) 
                 36.6 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 7.2 
               
               
                   
                 CC Margin (ODO3921) 
                 8.7 
               
               
                   
                 Colon cancer metastasis (OD06104) 
                 2.7 
               
               
                   
                 Lung Margin (OD06104) 
                 14.3 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 1.8 
               
               
                   
                 Lung Margin (OD04451-02) 
                 17.6 
               
               
                   
                 Normal Prostate 
                 86.5 
               
               
                   
                 Prostate Cancer (OD04410) 
                 12.4 
               
               
                   
                 Prostate Margin (OD04410) 
                 32.3 
               
               
                   
                 Normal Ovary 
                 74.7 
               
               
                   
                 Ovarian cancer (OD06283-03) 
                 8.5 
               
               
                   
                 Ovarian Margin (OD06283-07) 
                 34.4 
               
               
                   
                 Ovarian Cancer 064008 
                 17.3 
               
               
                   
                 Ovarian cancer (OD06145) 
                 17.3 
               
               
                   
                 Ovarian Margin (OD06145) 
                 25.0 
               
               
                   
                 Ovarian cancer (OD06455-03) 
                 6.4 
               
               
                   
                 Ovarian Margin (OD06455-07) 
                 100.0 
               
               
                   
                 Normal Lung 
                 18.9 
               
               
                   
                 Invasive poor diff. lung adeno (ODO4945-01 
                 7.7 
               
               
                   
                 Lung Margin (ODO4945-03) 
                 20.3 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 8.8 
               
               
                   
                 Lung Margin (OD03126) 
                 7.7 
               
               
                   
                 Lung Cancer (OD05014A) 
                 8.8 
               
               
                   
                 Lung Margin (OD05014B) 
                 29.1 
               
               
                   
                 Lung cancer (OD06081) 
                 11.1 
               
               
                   
                 Lung Margin (OD06081) 
                 6.5 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 8.7 
               
               
                   
                 Lung Margin (OD04237-02) 
                 27.7 
               
               
                   
                 Ocular Melanoma Metastasis 
                 3.1 
               
               
                   
                 Ocular Melanoma Margin (Liver) 
                 9.3 
               
               
                   
                 Melanoma Metastasis 
                 10.3 
               
               
                   
                 Melanoma Margin (Lung) 
                 18.2 
               
               
                   
                 Normal Kidney 
                 10.6 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 24.5 
               
               
                   
                 Kidney Margin (OD04338) 
                 4.9 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 5.2 
               
               
                   
                 Kidney Margin (OD04339) 
                 10.7 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 12.9 
               
               
                   
                 Kidney Margin (OD04340) 
                 10.1 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 14.6 
               
               
                   
                 Kidney Margin (OD04348) 
                 32.3 
               
               
                   
                 Kidney malignant cancer (OD06204B) 
                 2.2 
               
               
                   
                 Kidney normal adjacent tissue (OD06204E) 
                 9.1 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 2.9 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 7.8 
               
               
                   
                 Kidney Cancer 8120613 
                 1.2 
               
               
                   
                 Kidney Margin 8120614 
                 9.5 
               
               
                   
                 Kidney Cancer 9010320 
                 5.8 
               
               
                   
                 Kidney Margin 9010321 
                 3.7 
               
               
                   
                 Kidney Cancer 8120607 
                 16.6 
               
               
                   
                 Kidney Margin 8120608 
                 6.0 
               
               
                   
                 Normal Uterus 
                 88.9 
               
               
                   
                 Uterine Cancer 064011 
                 14.3 
               
               
                   
                 Normal Thyroid 
                 7.6 
               
               
                   
                 Thyroid Cancer 064010 
                 2.2 
               
               
                   
                 Thyroid Cancer A302152 
                 11.6 
               
               
                   
                 Thyroid Margin A302153 
                 3.9 
               
               
                   
                 Normal Breast 
                 95.3 
               
               
                   
                 Breast Cancer (OD04566) 
                 4.0 
               
               
                   
                 Breast Cancer 1024 
                 58.6 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 19.3 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 22.7 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 12.1 
               
               
                   
                 Breast Cancer 064006 
                 16.8 
               
               
                   
                 Breast Cancer 9100266 
                 13.9 
               
               
                   
                 Breast Margin 9100265 
                 51.4 
               
               
                   
                 Breast Cancer A209073 
                 13.8 
               
               
                   
                 Breast Margin A2090734 
                 42.0 
               
               
                   
                 Breast cancer (OD06083) 
                 26.6 
               
               
                   
                 Breast cancer node metastasis (OD06083) 
                 39.5 
               
               
                   
                 Normal Liver 
                 16.4 
               
               
                   
                 Liver Cancer 1026 
                 11.6 
               
               
                   
                 Liver Cancer 1025 
                 13.4 
               
               
                   
                 Liver Cancer 6004-T 
                 11.3 
               
               
                   
                 Liver Tissue 6004-N 
                 11.8 
               
               
                   
                 Liver Cancer 6005-T 
                 28.5 
               
               
                   
                 Liver Tissue 6005-N 
                 23.2 
               
               
                   
                 Liver Cancer 064003 
                 4.3 
               
               
                   
                 Normal Bladder 
                 12.3 
               
               
                   
                 Bladder Cancer 1023 
                 16.5 
               
               
                   
                 Bladder Cancer A302173 
                 8.9 
               
               
                   
                 Normal Stomach 
                 47.0 
               
               
                   
                 Gastric Cancer 9060397 
                 5.8 
               
               
                   
                 Stomach Margin 9060396 
                 17.6 
               
               
                   
                 Gastric Cancer 9060395 
                 19.1 
               
               
                   
                 Stomach Margin 9060394 
                 50.0 
               
               
                   
                 Gastric Cancer 064005 
                 8.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1402, Run 173860059    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE IF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Daoy- Medulloblastoma 
                 1.9 
               
               
                   
                 TE671- Medulloblastoma 
                 8.0 
               
               
                   
                 D283 Med- Medulloblastoma 
                 13.0 
               
               
                   
                 PFSK-1- Primitive Neuroectodermal 
                 61.1 
               
               
                   
                 XF-498- CNS 
                 16.0 
               
               
                   
                 SNB-78- Glioma 
                 81.8 
               
               
                   
                 SF-268- Glioblastoma 
                 4.5 
               
               
                   
                 T98G- Glioblastoma 
                 16.3 
               
               
                   
                 SK-N-SH- Neuroblastoma (metastasis) 
                 39.2 
               
               
                   
                 SF-295- Glioblastoma 
                 5.3 
               
               
                   
                 Cerebellum 
                 7.7 
               
               
                   
                 Cerebellum 
                 13.4 
               
               
                   
                 NCI-H292- Mucoepidermoid lung carcinoma 
                 2.1 
               
               
                   
                 DMS-114- Small cell lung cancer 
                 31.2 
               
               
                   
                 DMS-79- Small cell lung cancer 
                 31.9 
               
               
                   
                 NCI-H146- Small cell lung cancer 
                 3.1 
               
               
                   
                 NCI-H526- Small cell lung cancer 
                 9.5 
               
               
                   
                 NCI-N417- Small cell lung cancer 
                 0.2 
               
               
                   
                 NCI-H82- Small cell lung cancer 
                 3.7 
               
               
                   
                 NCI-H157- Squamous cell lung cancer (metastasis) 
                 1.4 
               
               
                   
                 NCI-H1155- Large cell lung cancer 
                 9.2 
               
               
                   
                 NCI-H1299- Large cell lung cancer 
                 1.5 
               
               
                   
                 NCI-H727- Lung carcinoid 
                 1.5 
               
               
                   
                 NCI-UMC-11- Lung carcinoid 
                 2.0 
               
               
                   
                 LX-1- Small cell lung cancer 
                 1.5 
               
               
                   
                 Colo-205- Colon cancer 
                 0.9 
               
               
                   
                 KM12- Colon cancer 
                 0.9 
               
               
                   
                 KM20L2- Colon cancer 
                 0.5 
               
               
                   
                 NCI-H716- Colon cancer 
                 5.6 
               
               
                   
                 SW-48- Colon adenocarcinoma 
                 0.3 
               
               
                   
                 SW1116- Colon adenocarcinoma 
                 5.3 
               
               
                   
                 LS 174T- Colon adenocarcinoma 
                 1.1 
               
               
                   
                 SW-948- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-480- Colon adenocarcinoma 
                 0.4 
               
               
                   
                 NCI-SNU-5- Gastric carcinoma 
                 0.8 
               
               
                   
                 KATO III- Gastric carcinoma 
                 2.4 
               
               
                   
                 NCI-SNU-16- Gastric carcinoma 
                 0.2 
               
               
                   
                 NCI-SNU-1- Gastric carcinoma 
                 1.6 
               
               
                   
                 RF-1- Gastric adenocarcinoma 
                 0.5 
               
               
                   
                 RF-48- Gastric adenocarcinoma 
                 0.9 
               
               
                   
                 MKN-45- Gastric carcinoma 
                 0.7 
               
               
                   
                 NCI-N87- Gastric carcinoma 
                 0.9 
               
               
                   
                 OVCAR-5- Ovarian carcinoma 
                 1.7 
               
               
                   
                 RL95-2- Uterine carcinoma 
                 6.7 
               
               
                   
                 HelaS3- Cervical adenocarcinoma 
                 3.3 
               
               
                   
                 Ca Ski- Cervical epidermoid carcinoma (metastasis) 
                 1.9 
               
               
                   
                 ES-2- Ovarian clear cell carcinoma 
                 3.2 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 0.8 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 0.6 
               
               
                   
                 MEG-01- Chronic myelogenous leukemia 
                 1.0 
               
               
                   
                 (megokaryoblast) 
               
               
                   
                 Raji- Burkitt&#39;s lymphoma 
                 0.1 
               
               
                   
                 Daudi- Burkitt&#39;s lymphoma 
                 1.0 
               
               
                   
                 U266- B-cell plasmacytoma 
                 1.0 
               
               
                   
                 CA46- Burkitt&#39;s lymphoma 
                 2.0 
               
               
                   
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 0.2 
               
               
                   
                 JM1- pre-B-cell lymphoma 
                 2.6 
               
               
                   
                 Jurkat- T cell leukemia 
                 5.1 
               
               
                   
                 TF-1- Erythroleukemia 
                 1.0 
               
               
                   
                 HUT 78- T-cell lymphoma 
                 3.6 
               
               
                   
                 U937- Histiocytic lymphoma 
                 100.0 
               
               
                   
                 KU-812- Myelogenous leukemia 
                 1.5 
               
               
                   
                 769-P- Clear cell renal carcinoma 
                 0.7 
               
               
                   
                 Caki-2- Clear cell renal carcinoma 
                 0.9 
               
               
                   
                 SW 839- Clear cell renal carcinoma 
                 0.5 
               
               
                   
                 Rhabdoid kidney tumor 
                 34.9 
               
               
                   
                 Hs766T- Pancreatic carcinoma (LN metastasis) 
                 0.9 
               
               
                   
                 CAPAN-1- Pancreatic adenocarcinoma (liver 
                 5.5 
               
               
                   
                 metastasis) 
               
               
                   
                 SU86.86- Pancreatic carcinoma (liver metastasis) 
                 1.7 
               
               
                   
                 BxPC-3- Pancreatic adenocarcinoma 
                 0.8 
               
               
                   
                 HPAC- Pancreatic adenocarcinoma 
                 0.2 
               
               
                   
                 MIA PaCa-2- Pancreatic carcinoma 
                 0.0 
               
               
                   
                 CFPAC-1- Pancreatic ductal adenocarcinoma 
                 2.1 
               
               
                   
                 PANC-1- Pancreatic epithelioid ductal carcinoma 
                 0.7 
               
               
                   
                 T24- Bladder carcinma (transitional cell) 
                 1.1 
               
               
                   
                 5637- Bladder carcinoma 
                 0.9 
               
               
                   
                 HT-1197- Bladder carcinoma 
                 0.6 
               
               
                   
                 UM-UC-3- Bladder carcinma (transitional cell) 
                 0.6 
               
               
                   
                 A204- Rhabdomyosarcoma 
                 12.3 
               
               
                   
                 HT-1080- Fibrosarcoma 
                 7.3 
               
               
                   
                 MG-63- Osteosarcoma 
                 11.9 
               
               
                   
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 5.0 
               
               
                   
                 SJRH30- Rhabdomyosarcoma (met to bone marrow) 
                 2.3 
               
               
                   
                 A431- Epidermoid carcinoma 
                 1.3 
               
               
                   
                 WM266-4- Melanoma 
                 8.7 
               
               
                   
                 DU 145- Prostate carcinoma (brain metastasis) 
                 0.0 
               
               
                   
                 MDA-MB-468- Breast adenocarcinoma 
                 1.8 
               
               
                   
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-9- Squamous cell carcinoma of tongue 
                 0.3 
               
               
                   
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.1 
               
               
                   
                 CAL 27- Squamous cell carcinoma of tongue 
                 0.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1402, Run 182113343    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE IG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Secondary Th1 act 
                 0.5 
                 1.0 
               
               
                 Secondary Th2 act 
                 0.2 
                 0.4 
               
               
                 Secondary Tr1 act 
                 0.9 
                 0.6 
               
               
                 Secondary Th1 rest 
                 0.3 
                 0.1 
               
               
                 Secondary Th2 rest 
                 0.4 
                 0.2 
               
               
                 Secondary Tr1 rest 
                 0.3 
                 0.2 
               
               
                 Primary Th1 act 
                 1.1 
                 0.8 
               
               
                 Primary Th2 act 
                 0.9 
                 0.8 
               
               
                 Primary Tr1 act 
                 1.9 
                 1.4 
               
               
                 Primary Th1 rest 
                 1.6 
                 1.1 
               
               
                 Primary Th2 rest 
                 0.7 
                 0.5 
               
               
                 Primary Tr1 rest 
                 1.6 
                 1.2 
               
               
                 CD45RA CD4 lymphocyte act 
                 16.7 
                 13.4 
               
               
                 CD45RO CD4 lymphocyte act 
                 0.5 
                 0.3 
               
               
                 CD8 lymphocyte act 
                 0.4 
                 0.3 
               
               
                 Secondary CD8 lymphocyte rest 
                 0.5 
                 0.4 
               
               
                 Secondary CD8 lymphocyte act 
                 0.6 
                 0.3 
               
               
                 CD4 lymphocyte none 
                 0.5 
                 0.4 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.6 
                 0.3 
               
               
                 LAK cells rest 
                 0.4 
                 0.4 
               
               
                 LAK cells IL-2 
                 0.5 
                 0.4 
               
               
                 LAK cells IL-2 + IL-12 
                 0.7 
                 0.5 
               
               
                 LAK cells IL-2 + IFN gamma 
                 0.9 
                 0.5 
               
               
                 LAK cells IL-2 + IL-18 
                 0.5 
                 0.3 
               
               
                 LAK cells PMA/ionomycin 
                 0.1 
                 0.1 
               
               
                 NK Cells IL-2 rest 
                 0.6 
                 0.5 
               
               
                 Two Way MLR 3 day 
                 0.5 
                 0.3 
               
               
                 Two Way MLR 5 day 
                 0.4 
                 0.2 
               
               
                 Two Way MLR 7 day 
                 0.3 
                 0.3 
               
               
                 PBMC rest 
                 0.9 
                 0.6 
               
               
                 PBMC PWM 
                 1.5 
                 1.2 
               
               
                 PBMC PHA-L 
                 2.1 
                 1.5 
               
               
                 Ramos (B cell) none 
                 0.6 
                 1.0 
               
               
                 Ramos (B cell) ionomycin 
                 1.1 
                 0.9 
               
               
                 B lymphocytes PWM 
                 1.0 
                 0.7 
               
               
                 B lymphocytes CD40L and IL-4 
                 0.5 
                 0.3 
               
               
                 EOL-1 dbcAMP 
                 7.0 
                 6.6 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 1.0 
                 0.7 
               
               
                 Dendritic cells none 
                 1.0 
                 0.5 
               
               
                 Dendritic cells LPS 
                 0.1 
                 0.1 
               
               
                 Dendritic cells anti-CD40 
                 0.5 
                 0.9 
               
               
                 Monocytes rest 
                 3.7 
                 2.5 
               
               
                 Monocytes LPS 
                 4.4 
                 3.7 
               
               
                 Macrophages rest 
                 0.2 
                 0.3 
               
               
                 Macrophages LPS 
                 0.3 
                 0.2 
               
               
                 HUVEC none 
                 7.6 
                 5.5 
               
               
                 HUVEC starved 
                 13.4 
                 12.4 
               
               
                 HUVEC IL-1beta 
                 2.6 
                 2.2 
               
               
                 HUVEC IFN gamma 
                 20.3 
                 18.2 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 1.5 
                 1.1 
               
               
                 HUVEC TNF alpha + IL4 
                 2.4 
                 2.4 
               
               
                 HUVEC IL-11 
                 14.0 
                 12.5 
               
               
                 Lung Microvascular EC none 
                 14.0 
                 12.0 
               
               
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 7.0 
                 7.2 
               
               
                 Microvascular Dermal EC none 
                 39.2 
                 40.1 
               
               
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 14.4 
                 12.4 
               
               
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.5 
                 0.5 
               
               
                 Small airway epithelium none 
                 2.1 
                 1.5 
               
               
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.2 
                 0.3 
               
               
                 Coronery artery SMC rest 
                 18.7 
                 17.9 
               
               
                 Coronery artery SMC TNFalpha + IL-1beta 
                 17.4 
                 13.6 
               
               
                 Astrocytes rest 
                 0.5 
                 0.3 
               
               
                 Astrocytes TNFalpha + IL-1beta 
                 0.6 
                 0.6 
               
               
                 KU-812 (Basophil) rest 
                 0.6 
                 0.4 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 1.0 
                 0.6 
               
               
                 CCD1106 (Keratinocytes) none 
                 0.1 
                 0.2 
               
               
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.6 
                 0.2 
               
               
                 Liver cirrhosis 
                 4.9 
                 5.7 
               
               
                 Lupus kidney 
                 5.3 
                 4.9 
               
               
                 NCI-H292 none 
                 0.6 
                 0.7 
               
               
                 NCI-H292 IL-4 
                 0.4 
                 0.7 
               
               
                 NCI-H292 IL-9 
                 1.1 
                 0.7 
               
               
                 NCI-H292 IL-13 
                 0.6 
                 0.5 
               
               
                 NCI-H292 IFN gamma 
                 0.7 
                 0.5 
               
               
                 HPAEC none 
                 12.0 
                 11.7 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 6.2 
                 5.1 
               
               
                 Lung fibroblast none 
                 64.6 
                 66.0 
               
               
                 Lung fibroblast TNF alpha + IL-1 beta 
                 26.6 
                 24.7 
               
               
                 Lung fibroblast IL-4 
                 64.6 
                 66.9 
               
               
                 Lung fibroblast IL-9 
                 51.4 
                 42.9 
               
               
                 Lung fibroblast IL-13 
                 100.0 
                 100.0 
               
               
                 Lung fibroblast IFN gamma 
                 84.1 
                 82.4 
               
               
                 Dermal fibroblast CCD1070 rest 
                 71.2 
                 60.7 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 41.8 
                 39.0 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 45.7 
                 43.8 
               
               
                 Dermal fibroblast IFN gamma 
                 25.3 
                 19.5 
               
               
                 Dermal fibroblast IL-4 
                 45.7 
                 42.0 
               
               
                 IBD Colitis 2 
                 1.2 
                 1.1 
               
               
                 IBD Crohn&#39;s 
                 2.0 
                 1.6 
               
               
                 Colon 
                 8.4 
                 8.2 
               
               
                 Lung 
                 29.9 
                 23.7 
               
               
                 Thymus 
                 11.3 
                 10.8 
               
               
                 Kidney 
                 7.1 
                 5.2 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag1402, Run 139531667    
               
               
                   Column B - Rel. Exp. (%) Ag1402, Run 145633378    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE IH 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 5 Islet 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 97457_Patient-02go_adipose 
                 32.5 
               
               
                   
                 97476_Patient-07sk_skeletal muscle 
                 23.2 
               
               
                   
                 97477_Patient-07ut_uterus 
                 27.0 
               
               
                   
                 97478_Patient-07pl_placenta 
                 62.9 
               
               
                   
                 99167_Bayer Patient 1 
                 6.9 
               
               
                   
                 97482_Patient-08ut_uterus 
                 45.1 
               
               
                   
                 97483_Patient-08pl_placenta 
                 55.9 
               
               
                   
                 97486_Patient-09sk_skeletal muscle 
                 6.4 
               
               
                   
                 97487_Patient-09ut_uterus 
                 68.8 
               
               
                   
                 97488_Patient-09pl_placenta 
                 42.0 
               
               
                   
                 97492_Patient-10ut_uterus 
                 100.0 
               
               
                   
                 97493_Patient-10pl_placenta 
                 51.4 
               
               
                   
                 97495_Patient-11go_adipose 
                 21.2 
               
               
                   
                 97496_Patient-11sk_skeletal muscle 
                 11.7 
               
               
                   
                 97497_Patient-11ut_uterus 
                 61.1 
               
               
                   
                 97498_Patient-11pl_placenta 
                 22.7 
               
               
                   
                 97500_Patient-12go_adipose 
                 40.6 
               
               
                   
                 97501_Patient-12sk_skeletal muscle 
                 22.2 
               
               
                   
                 97502_Patient-12ut_uterus 
                 73.2 
               
               
                   
                 97503_Patient-12pl_placenta 
                 22.8 
               
               
                   
                 94721_Donor 2 U - A_MesenchymalStem Cells 
                 51.8 
               
               
                   
                 94722_Donor 2 U - B_Mesenchymal Stem Cells 
                 40.9 
               
               
                   
                 94723_Donor 2 U - C_Mesenchymal Stem Cells 
                 37.9 
               
               
                   
                 94709_Donor 2 AM - A_adipose 
                 35.8 
               
               
                   
                 94710_Donor 2 AM - B_adipose 
                 23.3 
               
               
                   
                 94711_Donor 2 AM - C_adipose 
                 17.1 
               
               
                   
                 94712_Donor 2 AD - A_adipose 
                 49.3 
               
               
                   
                 94713_Donor 2 AD - B_adipose 
                 69.3 
               
               
                   
                 94714_Donor 2 AD - C_adipose 
                 66.9 
               
               
                   
                 94742_Donor 3 U - A_Mesenchymal Stem Cells 
                 17.0 
               
               
                   
                 94743_Donor 3 U - B_Mesenchymal Stem Cells 
                 23.5 
               
               
                   
                 94730_Donor 3 AM - A_adipose 
                 26.2 
               
               
                   
                 94731_Donor 3 AM - B_adipose 
                 16.2 
               
               
                   
                 94732_Donor 3 AM - C_adipose 
                 19.9 
               
               
                   
                 94733_Donor 3 AD - A_adipose 
                 34.4 
               
               
                   
                 94734_Donor 3 AD - B_adipose 
                 25.9 
               
               
                   
                 94735_Donor 3 AD - C_adipose 
                 34.2 
               
               
                   
                 77138_Liver_HepG2untreated 
                 19.5 
               
               
                   
                 73556_Heart_Cardiac stromal cells (primary) 
                 25.2 
               
               
                   
                 81735_Small Intestine 
                 20.6 
               
               
                   
                 72409_Kidney_Proximal Convoluted Tubule 
                 0.6 
               
               
                   
                 82685_Small intestine_Duodenum 
                 5.3 
               
               
                   
                 90650_Adrenal_Adrenocortical adenoma 
                 0.2 
               
               
                   
                 72410_Kidney_HRCE 
                 0.7 
               
               
                   
                 72411_Kidney_HRE 
                 1.8 
               
               
                   
                 73139_Uterus_Uterine smooth muscle cells 
                 45.1 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1402, Run 258861208    
               
            
           
         
       
     
      HASS Panel v1.0 Summary: Ag1402 Highest expression of this gene was detected in primary melanocytes A5 sample (CT=27). This gene showed wide spread expression in this panel with significant expression in astrocytes, glioma and the cancer cell lines subjected to serum starvation, acidosis and anoxia for different time periods. This expression pattern demonstrates that this gene or its protein product is important for cell survival and proliferation.  
      Human Metabolic Summary: Ag1402 Highest expression of this gene was detected in histiocystic lymphoma cell line(CT=23.6). This gene showed a ubiquitous expression with high expression in cancer cell lines, and metabolic tissues. Please see panel 1.2 for further discussion on the utility of this gene.  
      Panel 1.2 Summary: Ag1402 This gene was expressed at highest levels in heart (CT=22-23), prostate, and ovarian tissue and was expressed to a lesser degree across a number of samples in Panel 1.2. This gene was expressed largely in normal tissues when compared to cultured cell lines. Expression of this gene is useful for differentiating between heart, prostate and ovarian tissue from other tissues.  
      Among other metabolically relevant tissues, this gene was moderately expressed in thyroid, pituitary gland, and pancreas, and was highly expressed in adrenal gland, skeletal muscle and fetal/adult liver. High expression of this gene in insulin-responsive tissues such as skeletal muscle and liver demonstrates that this gene or gene product is an effective drug target for the treatment of Type 2 diabetes. High expression in adrenal gland and heart also shows that this gene or its protein product is an antibody, protein, or small molecule target for the treatment of diseases involving these two tissues.  
      This gene encodes a putative leucine-rich-repeat (LRR), GPCR-like protein. In  Drosophilia,  the LRR region of axon guidance proteins has been shown to be critical for function, especially in axon repulsion (Battye R. J. Neurosci. 21: 4290-4298.). The leucine-rich-repeat protein encoded by this gene showed high expression across all brain regions, with expression detected in amygdala, cerebellum, hippocampus, thalamus, cerebral cortex and spinal cord, making it an excellent candidate neuronal guidance protein for axons, dendrites and/or growth cones in general. Therapeutic modulation of the levels of this gene or protein, or possible signaling via this protein, is of utility in enhancing/directing compensatory synaptogenesis and fiber growth in the CNS in response to neuronal death (stroke, head trauma), axon lesion (spinal cord injury), or neurodegeneration (Alzheimer&#39;s, Parkinson&#39;s, Huntington&#39;s, vascular dementia or any neurodegenerative disease). In addition, the this gene showed very high levels of expression in the substantia nigra, where loss of dopaminergic neurons is a hallmark of Parkinson&#39;s disease and progressive supranuclear palsy. Therapies based upon this gene or its protein product are useful in the treatment of these diseases.  
      This protein also contains homology to the GPCR family of receptors. Several neurotransmitter receptors are GPCRs, including the dopamine receptor family, the serotonin receptor family, the GABAB receptor, muscarinic acetylcholine receptors, and others; thus this GPCR represents a novel neurotransmitter receptor. Targeting various neurotransmitter receptors (dopamine, serotonin) has proven to be an effective therapy in psychiatric illnesses such as schizophrenia, bipolar disorder and depression. Furthermore the cerebral cortex and hippocampus are regions of the brain that are known to play critical roles in Alzheimer&#39;s disease, seizure disorders, and in the normal process of memory formation. Therapeutic modulation of this gene or its protein product is beneficial in one or more of these diseases, as is stimulation and/or blockade of the receptor coded for by the gene. Levels of this gene were high, however, in areas outside of the central nervous system (such as the heart, ovaries, and prostate), demonstrating the possibility of a wider role in intercellular signaling.  
      Panel 2.2 Summary: Ag1402 Among the samples on this panel, expression of this gene was highest in a sample of normal ovarian tissue adjacent to an ovarian cancer (CT=28.5). There was also a predominance of this expression pattern in a number of other matched normal tissue samples including lung, colon and kidney. Umatched normal tissue samples, such as breast, uterus, ovary and prostate also showed appreciable expression of this gene. This gene or its protein product are useful in differentiating adjacent normal tissue from corresponding malignant tissue for the above listed tissue types. The therapeutic modulation of the gene or the protein encoded by this gene is of use in the treatment of the above listed malignancies.  
      Panel 3D Summary: : Ag1402 Expression of this gene was highest in a sample derived from a histiocytic lymphoma cell line (CT=28.2). This gene was also highly expressed in several CNS cancer cell lines and cell lines derived from a variety of sarcomas. The expression of this gene is useful for the differentiation of cell lines derived from sarcomas and CNS cancers vs. other cell lines. Therapeutic modulation of this gene or gene product is of therapeutic benefit in the treatment of sarcomas or CNS cancers.  
      Panel 4D Summary: This gene was highly expressed in endothelium and fibroblasts and was selectively down regulated in these tissues by treatment with IL-1beta and TNFalpha. This gene encodes a putative LRR-containing GPCR that is down regulated in response to the proinflammatory cytokines IL-1beta and TNFalpha in endothelium and fibroblasts. The natural ligand for this GPCR is induced by treatment with TNF and IL-1 and subsequent ligand binding to this putative GPCR results in feedback inhibition. Other signaling pathways induced by TNF and IL-1 reduce the level of transcription of this gene. Antibodies, small molecule or protein therapeutics which prevent the signaling through this putative GPCR are important in the treatment of diseases such as asthma, emphysema, psoriasis, and arthritis.  
      Panel 5 Islet Summary: Ag1402 Highest expression of this gene was detected in the uterus of a diabetic patient on insulin (CT=28). This gene showed widespread expression in this panel. This pattern was in agreement with the expression profile in General_screening_panel_v1.2 and demonstrates a role for the gene product in cell survival and proliferation. Please see panel 1.2 for further discussion on the utility of this gene.  
      J. CG51027-06: Optoid Binding Protein/Cell Adhesion Molecule Precursor  
      Expression of full-length physical clone CG51027-06 was assessed using the primer-probe set Ag6959, described in Table JA. Results of the RTQ-PCR runs are shown in Table JB.  
                   TABLE JA                          Probe Name Ag6959                                                     Start   SEQ ID           Primers   Sequences   Length   Position   No                                             Forward   5′-gtctacctcattgtccacgt-3′   20   420   1294                   Probe   TET-5′-ctcgtcgcctgtgatggtgaatga-3′-   24   461   1295           TAMRA               Reverse   5′-caaagcaggttcacattgc-3′   19   490   1296                  
 
     
       
         
           
               
             
               
                 TABLE JB 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.6 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 0.2 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.1 
               
               
                   
                 Melanoma* M14 
                 0.1 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.3 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.0 
               
               
                   
                 Testis Pool 
                 5.8 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate Pool 
                 0.2 
               
               
                   
                 Placenta 
                 0.0 
               
               
                   
                 Uterus Pool 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.2 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.4 
               
               
                   
                 Ovary 
                 4.5 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca. BT 549 
                 0.1 
               
               
                   
                 Breast ca. T47D 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Breast Pool 
                 0.3 
               
               
                   
                 Trachea 
                 0.1 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Fetal Lung 
                 1.6 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 1.3 
               
               
                   
                 Lung ca. A549 
                 0.0 
               
               
                   
                 Lung ca. NCI-H526 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 25.0 
               
               
                   
                 Lung ca. NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. HOP-62 
                 0.1 
               
               
                   
                 Lung ca. NCI-H522 
                 21.5 
               
               
                   
                 Liver 
                 0.3 
               
               
                   
                 Fetal Liver 
                 1.0 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
               
               
                   
                 Kidney Pool 
                 0.1 
               
               
                   
                 Fetal Kidney 
                 2.3 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.1 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Bladder 
                 0.2 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.0 
               
               
                   
                 Gastric ca. KATO III 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon cancer tissue 
                 0.6 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 0.2 
               
               
                   
                 Small Intestine Pool 
                 0.2 
               
               
                   
                 Stomach Pool 
                 0.2 
               
               
                   
                 Bone Marrow Pool 
                 0.0 
               
               
                   
                 Fetal Heart 
                 0.2 
               
               
                   
                 Heart Pool 
                 0.0 
               
               
                   
                 Lymph Node Pool 
                 0.0 
               
               
                   
                 Fetal Skeletal Muscle 
                 0.0 
               
               
                   
                 Skeletal Muscle Pool 
                 0.0 
               
               
                   
                 Spleen Pool 
                 0.2 
               
               
                   
                 Thymus Pool 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 0.0 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 3.8 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 0.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.1 
               
               
                   
                 Brain (Amygdala) Pool 
                 9.3 
               
               
                   
                 Brain (cerebellum) 
                 100.0 
               
               
                   
                 Brain (fetal) 
                 61.1 
               
               
                   
                 Brain (Hippocampus) Pool 
                 9.2 
               
               
                   
                 Cerebral Cortex Pool 
                 25.9 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 18.0 
               
               
                   
                 Brain (Thalamus) Pool 
                 16.3 
               
               
                   
                 Brain (whole) 
                 22.8 
               
               
                   
                 Spinal Cord Pool 
                 18.3 
               
               
                   
                 Adrenal Gland 
                 0.9 
               
               
                   
                 Pituitary gland Pool 
                 0.6 
               
               
                   
                 Salivary Gland 
                 0.0 
               
               
                   
                 Thyroid (female) 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.0 
               
               
                   
                 Pancreas Pool 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag6959, Run 278388920    
               
            
           
         
       
     
      General_screeningpanel_v1.6 Summary: Ag6959 Highest expression of this gene was detected in cerebellum (CT=28.6). This gene showed a highly brain-preferential expression, and was expressed at moderate levels in all brain regions examined. This gene codes for a homolog of rat opioid-binding cell adhesion molecule (OBCAM), which is involved in axonal outgrowth (Hachisuka A, Brain Res Dev Brain Res 122(2):183-91) and may be involved in the synaptic machinery. The limited ability of the CNS to regenerate after injury is the major impediment to the treatment of stroke, spinal cord and head trauma, and neurodegenerative diseases. Modulation of this gene, expressed protein and/or use of antibodies or small molecule drug targeting this gene or gene product is useful in enhancing neuroregeneration in any or all of these clinical conditions.  
      Moderate expression of this gene was also seen in two lung cancer cell line. Expression of this gene is useful as marker to detect the presence of lung cancer and modulation of this gene or expressed protein is useful in the treatment of lung cancer.  
      K. CG51027-09: Optiod Bindin Protein/Cell Adhesion Molecule Precursor  
      Expression of gene CG51027-09 was assessed using the primer-probe sets Ag3090 and Ag3092, described in Tables KA and KB. Results of the RTQ-PCR runs are shown in Tables KC and KD.  
                   TABLE KA                          Probe Name Ag3090                                                     Start   SEQ ID           Primers   Sequences   Length   Position   No                                             Forward   5′-atgacagactgctgagcagc-3′   20   241   1297                   Probe   TET-5′-aaggcctgaaggtgcagacggag-3′-   23   208   1298           TAMRA               Reverse   5′-cgttggcaaagagaagcat-3′   19   177   1299                  
 
     
       
         
           
               
             
               
                 TABLE KB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag3092 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-atgacagactgctgagcagc-3′ 
                 20 
                 241 
                 1300 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-aaggcctgaaggtgcagacggag-3′- 
                 23 
                 208 
                 1301 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-cgttggcaaagagaagcat-3′ 
                 19 
                 177 
                 1302 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE KC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 0.3 
                 0.0 
               
               
                   
                 Pancreas 
                 0.0 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
                 0.0 
               
               
                   
                 Adrenal gland 
                 1.5 
                 0.0 
               
               
                   
                 Thyroid 
                 0.0 
                 0.0 
               
               
                   
                 Salivary gland 
                 0.0 
                 0.0 
               
               
                   
                 Pituitary gland 
                 3.4 
                 0.2 
               
               
                   
                 Brain (fetal) 
                 100.0 
                 53.6 
               
               
                   
                 Brain (whole) 
                 29.5 
                 51.8 
               
               
                   
                 Brain (amygdala) 
                 31.9 
                 51.1 
               
               
                   
                 Brain (cerebellum) 
                 94.0 
                 71.7 
               
               
                   
                 Brain (hippocampus) 
                 41.2 
                 91.4 
               
               
                   
                 Brain (substantia nigra) 
                 27.0 
                 24.7 
               
               
                   
                 Brain (thalamus) 
                 20.3 
                 100.0 
               
               
                   
                 Cerebral Cortex 
                 89.5 
                 37.4 
               
               
                   
                 Spinal cord 
                 16.4 
                 7.9 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 2.2 
                 3.2 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 1.4 
                 0.0 
               
               
                   
                 glioma SNB-19 
                 0.0 
                 0.2 
               
               
                   
                 glioma U251 
                 0.8 
                 0.0 
               
               
                   
                 glioma SF-295 
                 0.0 
                 0.1 
               
               
                   
                 Heart (fetal) 
                 0.0 
                 0.1 
               
               
                   
                 Heart 
                 0.0 
                 0.0 
               
               
                   
                 Skeletal muscle (fetal) 
                 0.0 
                 5.2 
               
               
                   
                 Skeletal muscle 
                 0.2 
                 0.0 
               
               
                   
                 Bone marrow 
                 0.0 
                 0.0 
               
               
                   
                 Thymus 
                 0.0 
                 1.6 
               
               
                   
                 Spleen 
                 0.3 
                 1.6 
               
               
                   
                 Lymph node 
                 0.0 
                 0.0 
               
               
                   
                 Colorectal 
                 1.7 
                 0.1 
               
               
                   
                 Stomach 
                 0.0 
                 0.0 
               
               
                   
                 Small intestine 
                 0.5 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 0.4 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.5 
                 0.1 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
                 0.2 
               
               
                   
                 Colon ca. CaCo-2 
                 0.5 
                 0.0 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 5.8 
                 0.9 
               
               
                   
                 Colon ca. HCC-2998 
                 0.7 
                 1.0 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.3 
                 0.0 
               
               
                   
                 Bladder 
                 0.0 
                 0.0 
               
               
                   
                 Trachea 
                 0.0 
                 0.0 
               
               
                   
                 Kidney 
                 0.0 
                 0.0 
               
               
                   
                 Kidney (fetal) 
                 13.3 
                 4.4 
               
               
                   
                 Renal ca. 786-0 
                 0.2 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
                 0.1 
               
               
                   
                 Renal ca. RXF 393 
                 0.1 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.5 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
                 0.8 
               
               
                   
                 Liver (fetal) 
                 1.2 
                 0.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 21.2 
                 5.4 
               
               
                   
                 Lung 
                 0.0 
                 0.0 
               
               
                   
                 Lung (fetal) 
                 1.8 
                 2.1 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.2 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 1.6 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.0 
                 2.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.8 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 21.3 
                 10.2 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 27.0 
                 3.7 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
                 0.1 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
                 0.0 
               
               
                   
                 Mammary gland 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.5 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
                 0.1 
               
               
                   
                 Breast ca. MDA-N 
                 0.4 
                 0.0 
               
               
                   
                 Ovary 
                 9.0 
                 2.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 1.1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.5 
                 0.4 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
                 0.1 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.0 
                 2.6 
               
               
                   
                 Uterus 
                 0.0 
                 0.0 
               
               
                   
                 Placenta 
                 0.0 
                 0.0 
               
               
                   
                 Prostate 
                 0.0 
                 0.3 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 0.2 
                 0.1 
               
               
                   
                 Testis 
                 5.9 
                 15.0 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
                 0.1 
               
               
                   
                 Melanoma M14 
                 0.0 
                 0.1 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
                 0.0 
               
               
                   
                 Adipose 
                 3.1 
                 0.8 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3090, Run 167985244    
               
               
                   
                   Column B - Rel. Exp. (%) Ag3092, Run 165673593    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE KD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Secondary Th1 act 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 act 
                 0.1 
                 100.0 
               
               
                 Secondary Tr1 act 
                 0.1 
                 0.0 
               
               
                 Secondary Th1 rest 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 rest 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 rest 
                 0.0 
                 0.0 
               
               
                 Primary Th1 act 
                 0.0 
                 6.2 
               
               
                 Primary Th2 act 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 act 
                 0.0 
                 0.0 
               
               
                 Primary Th1 rest 
                 0.0 
                 0.0 
               
               
                 Primary Th2 rest 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 rest 
                 0.0 
                 0.0 
               
               
                 CD45RA CD4 lymphocyte act 
                 0.0 
                 2.9 
               
               
                 CD45RO CD4 lymphocyte act 
                 0.0 
                 5.3 
               
               
                 CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte rest 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD4 lymphocyte none 
                 0.0 
                 0.0 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
                 14.2 
               
               
                 LAK cells rest 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-12 
                 0.1 
                 0.0 
               
               
                 LAK cells IL-2 + IFN gamma 
                 0.0 
                 15.2 
               
               
                 LAK cells IL-2 + IL-18 
                 0.0 
                 0.0 
               
               
                 LAK cells PMA/ionomycin 
                 100.0 
                 3.6 
               
               
                 NK Cells IL-2 rest 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 3 day 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 5 day 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 7 day 
                 0.0 
                 14.6 
               
               
                 PBMC rest 
                 0.0 
                 4.2 
               
               
                 PBMC PWM 
                 0.3 
                 14.2 
               
               
                 PBMC PHA-L 
                 0.5 
                 37.1 
               
               
                 Ramos (B cell) none 
                 0.1 
                 0.0 
               
               
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
               
               
                 B lymphocytes PWM 
                 0.2 
                 2.6 
               
               
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.5 
                 37.9 
               
               
                 Dendritic cells none 
                 0.0 
                 0.0 
               
               
                 Dendritic cells LPS 
                 0.0 
                 17.3 
               
               
                 Dendritic cells anti-CD40 
                 0.0 
                 0.0 
               
               
                 Monocytes rest 
                 0.0 
                 0.0 
               
               
                 Monocytes LPS 
                 0.0 
                 0.0 
               
               
                 Macrophages rest 
                 0.0 
                 0.0 
               
               
                 Macrophages LPS 
                 0.0 
                 5.0 
               
               
                 HUVEC none 
                 0.0 
                 0.0 
               
               
                 HUVEC starved 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-1beta 
                 0.0 
                 0.0 
               
               
                 HUVEC IFN gamma 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IL4 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-11 
                 0.0 
                 0.0 
               
               
                 Lung Microvascular EC none 
                 0.0 
                 0.0 
               
               
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
                 4.9 
               
               
                 Microvascular Dermal EC none 
                 0.0 
                 0.0 
               
               
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
                 0.0 
               
               
                 Small airway epithelium none 
                 0.0 
                 0.0 
               
               
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Coronery artery SMC rest 
                 0.1 
                 24.7 
               
               
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Astrocytes rest 
                 0.0 
                 0.0 
               
               
                 Astrocytes TNFalpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) rest 
                 0.0 
                 25.9 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 0.1 
                 23.3 
               
               
                 CCD1106 (Keratinocytes) none 
                 0.0 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Liver cirrhosis 
                 0.6 
                 25.3 
               
               
                 Lupus kidney 
                 0.0 
                 0.0 
               
               
                 NCI-H292 none 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IL-4 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IL-9 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IL-13 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IFN gamma 
                 0.0 
                 0.0 
               
               
                 HPAEC none 
                 0.0 
                 0.0 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
                 2.2 
               
               
                 Lung fibroblast none 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-4 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-9 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-13 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 rest 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.1 
                 0.0 
               
               
                 Dermal fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast IL-4 
                 0.1 
                 0.0 
               
               
                 IBD Colitis 2 
                 0.0 
                 0.0 
               
               
                 IBD Crohn&#39;s 
                 0.0 
                 0.0 
               
               
                 Colon 
                 0.5 
                 52.1 
               
               
                 Lung 
                 0.3 
                 58.2 
               
               
                 Thymus 
                 0.0 
                 0.0 
               
               
                 Kidney 
                 0.0 
                 0.0 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag3090, Run 164391872    
               
               
                   Column B - Rel. Exp. (%) Ag3092, Run 164399701    
               
            
           
         
       
     
      Panel 1.3D Summary: Ag3090/Ag3092 Highest expression of this gene was detected in regions of the brain, specifically the thalamus and fetal brain (CTS=29-30). This gene showed a highly brain-preferential expression, and was expressed at high levels in all brain regions examined. The protein encoded by this gene is a homolog of opioid-binding cell adhesion molecule (OBCAM), which is involved in axonal outgrowth and in the synaptic machinery. The limited ability of the CNS to regenerate after injury is the major impediment to the treatment of stroke, spinal cord and head trauma, and neurodegenerative diseases. Selective modulation of this gene or its protein product is useful in enhancing neuroregeneration in any or all of these clinical conditions.  
      Panel 4D Sumnary: Ag3092 Expression of this gene was limited to a sample derived from secondary Th2 cells (CT=34.2). Therapeutic modulation of this gene or expressed protein is useful in reducing or eliminating the symptoms in patients with diseases related to the functions of Th2 cells, including asthma and allergies.  
      L. CG51373-08 and CG51373-10 and CG51373-11: Weakly Similar to Neural Cell Adhesion Molecule 1, Large Isoform Precursor  
      Expression of full-length physical clone CG51373-08 and variants CG51373-10 and CG51373-11 was assessed using the primer-probe sets Ag271 and Ag271b, described in Tables LA and LB. Results of the RTQ-PCR runs are shown in Tables LC, LD, LE, LF and LG.  
                   TABLE LA                          Probe Name Ag271                                                     Start   SEQ ID           Primers   Sequences   Length   Position   No                                             Forward   5′-acctggacatagggcgtgtct-3′   21   690   1303                   Probe   TET-5′-cgaagcatgaacgaagccatccctag-3′-   26   656   1304           TAMRA               Reverse   5′-tcgatggaagtctccttgcc-3′   20   635   1305                  
 
     
       
         
           
               
               
             
               
                 TABLE LB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag271b 
                   
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-caccgtgagccaactgcttat-3′ 
                 21 
                 1722 
                 1306 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-agacacgccctatgtccaggtccg-3′- 
                 24 
                 1690 
                 1307 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-ttcgttcatgcttcggcaa-3′ 
                 19 
                 1667 
                 1308 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE LC 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.4 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Adipose 
                 6.4 
                 6.4 
               
               
                   
                 Melanoma* Hs688(A).T 
                 29.7 
                 28.1 
               
               
                   
                 Melanoma* Hs688(B).T 
                 26.4 
                 25.7 
               
               
                   
                 Melanoma* M14 
                 49.0 
                 48.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 28.7 
                 31.2 
               
               
                   
                 Melanoma* SK-MEL-5 
                 9.4 
                 11.7 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 5.0 
                 5.4 
               
               
                   
                 Testis Pool 
                 1.8 
                 1.6 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 19.8 
                 22.4 
               
               
                   
                 Prostate Pool 
                 2.0 
                 2.4 
               
               
                   
                 Placenta 
                 4.5 
                 7.7 
               
               
                   
                 Uterus Pool 
                 2.3 
                 2.7 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 45.1 
                 54.3 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 88.9 
                 87.1 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 15.9 
                 17.7 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 29.9 
                 29.1 
               
               
                   
                 Ovarian ca. IGROV-1 
                 54.0 
                 50.3 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 29.9 
                 36.9 
               
               
                   
                 Ovary 
                 11.0 
                 10.4 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.0 
                 29.7 
               
               
                   
                 Breast ca. BT 549 
                 88.3 
                 100.0 
               
               
                   
                 Breast ca. T47D 
                 53.2 
                 60.3 
               
               
                   
                 Breast ca. MDA-N 
                 13.6 
                 17.2 
               
               
                   
                 Breast Pool 
                 7.6 
                 9.7 
               
               
                   
                 Trachea 
                 3.5 
                 4.7 
               
               
                   
                 Lung 
                 1.1 
                 1.8 
               
               
                   
                 Fetal Lung 
                 14.0 
                 18.7 
               
               
                   
                 Lung ca. NCI-N417 
                 3.3 
                 2.9 
               
               
                   
                 Lung ca. LX-1 
                 1.5 
                 2.2 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.1 
                 0.2 
               
               
                   
                 Lung ca. A549 
                 8.0 
                 9.7 
               
               
                   
                 Lung ca. NCI-H526 
                 0.9 
                 0.6 
               
               
                   
                 Lung ca. NCI-H23 
                 9.0 
                 10.4 
               
               
                   
                 Lung ca. NCI-H460 
                 15.0 
                 19.3 
               
               
                   
                 Lung ca. HOP-62 
                 15.4 
                 20.91 
               
               
                   
                 Lung ca. NCI-H522 
                 1.8 
                 2.0 
               
               
                   
                 Liver 
                 0.2 
                 0.2 
               
               
                   
                 Fetal Liver 
                 1.8 
                 2.4 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Pool 
                 7.6 
                 12.9 
               
               
                   
                 Fetal Kidney 
                 10.2 
                 13.8 
               
               
                   
                 Renal ca. 786-0 
                 62.9 
                 77.9 
               
               
                   
                 Renal ca. A498 
                 21.8 
                 22.4 
               
               
                   
                 Renal ca. ACHN 
                 45.4 
                 49.3 
               
               
                   
                 Renal ca. UO-31 
                 37.6 
                 32.1 
               
               
                   
                 Renal ca. TK-10 
                 36.6 
                 37.4 
               
               
                   
                 Bladder 
                 4.0 
                 6.9 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 1.8 
                 2.7 
               
               
                   
                 Gastric ca. KATO III 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 4.0 
                 4.2 
               
               
                   
                 Colon ca. SW480 
                 7.5 
                 9.1 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 2.7 
                 3.2 
               
               
                   
                 Colon ca. HT29 
                 1.3 
                 2.3 
               
               
                   
                 Colon ca. HCT-116 
                 7.0 
                 8.3 
               
               
                   
                 Colon ca. CaCo-2 
                 13.2 
                 17.6 
               
               
                   
                 Colon cancer tissue 
                 6.3 
                 6.7 
               
               
                   
                 Colon ca. SW1116 
                 0.1 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.5 
                 0.5 
               
               
                   
                 Colon Pool 
                 5.9 
                 5.6 
               
               
                   
                 Small Intestine Pool 
                 4.2 
                 4.1 
               
               
                   
                 Stomach Pool 
                 5.4 
                 5.7 
               
               
                   
                 Bone Marrow Pool 
                 3.0 
                 3.6 
               
               
                   
                 Fetal Heart 
                 1.7 
                 1.7 
               
               
                   
                 Heart Pool 
                 3.1 
                 3.1 
               
               
                   
                 Lymph Node Pool 
                 6.8 
                 10.5 
               
               
                   
                 Fetal Skeletal Muscle 
                 2.4 
                 2.1 
               
               
                   
                 Skeletal Muscle Pool 
                 1.6 
                 1.4 
               
               
                   
                 Spleen Pool 
                 2.9 
                 3.5 
               
               
                   
                 Thymus Pool 
                 5.6 
                 5.8 
               
               
                   
                 CMS cancer (glio/astro) U87-MG 
                 25.0 
                 31.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 47.3 
                 56.6 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 18.8 
                 23.2 
               
               
                   
                 CNS cancer (astro) SF-539 
                 36.9 
                 44.8 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 100.0 
                 100.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 28.7 
                 57.4 
               
               
                   
                 CNS cancer (glio) SF-295 
                 64.6 
                 79.6 
               
               
                   
                 Brain (Amygdala) Pool 
                 0.4 
                 0.3 
               
               
                   
                 Brain (cerebellum) 
                 1.2 
                 1.3 
               
               
                   
                 Brain (fetal) 
                 6.9 
                 9.0 
               
               
                   
                 Brain (Hippocampus) Pool 
                 0.8 
                 0.6 
               
               
                   
                 Cerebral Cortex Pool 
                 0.5 
                 0.5 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 0.6 
                 0.8 
               
               
                   
                 Brain (Thalamus) Pool 
                 0.9 
                 0.8 
               
               
                   
                 Brain (whole) 
                 1.0 
                 1.1 
               
               
                   
                 Spinal Cord Pool 
                 0.8 
                 0.7 
               
               
                   
                 Adrenal Gland 
                 6.5 
                 5.7 
               
               
                   
                 Pituitary gland Pool 
                 0.4 
                 0.4 
               
               
                   
                 Salivary Gland 
                 1.5 
                 1.4 
               
               
                   
                 Thyroid (female) 
                 1.8 
                 1.8 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 24.8 
                 23.2 
               
               
                   
                 Pancreas Pool 
                 7.7 
                 9.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag271, Run 216607738    
               
               
                   
                   Column B - Rel. Exp. (%) Ag271b, Run 216607756    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE LD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
                 C 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Endothelial cells 
                 11.0 
                 5.0 
                 3.9 
               
               
                   
                 Endothelial cells (treated) 
                 3.8 
                 4.3 
                 4.9 
               
               
                   
                 Pancreas 
                 2.7 
                 3.1 
                 1.9 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 38.2 
                 24.0 
                 19.8 
               
               
                   
                 Adrenal gland 
                 14.1 
                 8.2 
                 12.7 
               
               
                   
                 Thyroid 
                 8.6 
                 6.1 
                 4.5 
               
               
                   
                 Salivary gland 
                 3.5 
                 4.1 
                 3.3 
               
               
                   
                 Pituitary gland 
                 9.5 
                 10.2 
                 7.3 
               
               
                   
                 Brain (fetal) 
                 7.4 
                 9.0 
                 5.3 
               
               
                   
                 Brain (whole) 
                 0.8 
                 3.7 
                 1.3 
               
               
                   
                 Brain (amygdala) 
                 0.1 
                 1.7 
                 1.7 
               
               
                   
                 Brain (cerebellum) 
                 4.8 
                 10.5 
                 2.3 
               
               
                   
                 Brain (hippocampus) 
                 0.2 
                 1.2 
                 1.4 
               
               
                   
                 Brain (substantia nigra) 
                 0.9 
                 3.5 
                 2.1 
               
               
                   
                 Brain (thalamus) 
                 0.7 
                 2.7 
                 3.2 
               
               
                   
                 Brain (hypothalamus) 
                 0.5 
                 3.4 
                 3.3 
               
               
                   
                 Spinal cord 
                 2.1 
                 4.0 
                 3.6 
               
               
                   
                 glio/astro U87-MG 
                 30.8 
                 24.0 
                 27.4 
               
               
                   
                 glio/astro U-118-MG 
                 28.5 
                 24.8 
                 20.0 
               
               
                   
                 astrocytoma SW1783 
                 21.0 
                 17.1 
                 17.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 24.1 
                 17.6 
                 29.9 
               
               
                   
                 astrocytoma SF-539 
                 35.6 
                 27.4 
                 41.2 
               
               
                   
                 astrocytoma SNB-75 
                 56.3 
                 65.1 
                 32.8 
               
               
                   
                 glioma SNB-19 
                 42.6 
                 53.6 
                 55.9 
               
               
                   
                 glioma U251 
                 39.8 
                 26.8 
                 48.3 
               
               
                   
                 glioma SF-295 
                 43.2 
                 33.4 
                 31.9 
               
               
                   
                 Heart 
                 15.2 
                 4.5 
                 6.8 
               
               
                   
                 Skeletal muscle 
                 0.1 
                 1.9 
                 4.6 
               
               
                   
                 Bone marrow 
                 1.1 
                 1.7 
                 2.1 
               
               
                   
                 Thymus 
                 28.1 
                 18.9 
                 10.2 
               
               
                   
                 Spleen 
                 2.5 
                 5.1 
                 3.2 
               
               
                   
                 Lymph node 
                 6.8 
                 6.0 
                 2.0 
               
               
                   
                 Colon (ascending) 
                 3.4 
                 3.2 
                 2.6 
               
               
                   
                 Stomach 
                 11.6 
                 12.0 
                 3.3 
               
               
                   
                 Small intestine 
                 5.9 
                 8.7 
                 5.5 
               
               
                   
                 Colon ca. SW480 
                 0.0 
                 1.8 
                 5.2 
               
               
                   
                 Colon ca.* SW620 (SW480 met) 
                 1.5 
                 2.4 
                 3.3 
               
               
                   
                 Colon ca. HT29 
                 0.1 
                 1.7 
                 3.2 
               
               
                   
                 Colon ca. HCT-116 
                 13.0 
                 10.4 
                 8.9 
               
               
                   
                 Colon ca. CaCo-2 
                 27.9 
                 21.8 
                 17.3 
               
               
                   
                 Colon ca. HCT-15 
                 1.7 
                 5.0 
                 7.3 
               
               
                   
                 Colon ca. HCC-2998 
                 0.4 
                 1.2 
                 2.7 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 1.1 
                 3.1 
                 3.5 
               
               
                   
                 Bladder 
                 30.8 
                 15.9 
                 19.1 
               
               
                   
                 Trachea 
                 7.2 
                 7.0 
                 4.5 
               
               
                   
                 Kidney 
                 14.8 
                 8.9 
                 9.8 
               
               
                   
                 Kidney (fetal) 
                 53.6 
                 55.9 
                 27.7 
               
               
                   
                 Renal ca. 786-0 
                 94.6 
                 96.6 
                 70.2 
               
               
                   
                 Renal ca. A498 
                 65.5 
                 65.5 
                 46.3 
               
               
                   
                 Renal ca. RXF 393 
                 41.8 
                 27.7 
                 29.1 
               
               
                   
                 Renal ca. ACHN 
                 66.9 
                 65.1 
                 51.4 
               
               
                   
                 Renal ca. UO-31 
                 46.0 
                 41.8 
                 54.0 
               
               
                   
                 Renal ca. TK-10 
                 57.0 
                 56.6 
                 52.9 
               
               
                   
                 Liver 
                 2.0 
                 3.3 
                 4.4 
               
               
                   
                 Liver (fetal) 
                 2.0 
                 2.4 
                 2.9 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung 
                 27.9 
                 8.0 
                 5.0 
               
               
                   
                 Lung (fetal) 
                 23.8 
                 11.9 
                 5.3 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.0 
                 1.4 
                 3.2 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 2.9 
                 4.2 
                 8.2 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
                 0.4 
                 0.2 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 29.5 
                 27.0 
                 51.4 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 6.6 
                 7.1 
                 12.2 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 6.6 
                 7.1 
                 17.2 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 19.1 
                 15.8 
                 40.9 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 4.3 
                 5.4 
                 5.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 15.8 
                 17.1 
                 19.1 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 8.3 
                 8.7 
                 10.5 
               
               
                   
                 Mammary gland 
                 47.6 
                 45.1 
                 28.9 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 17.1 
                 15.1 
                 18.4 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 3.1 
                 5.3 
                 6.4 
               
               
                   
                 Breast ca. BT-549 
                 70.7 
                 65.1 
                 26.1 
               
               
                   
                 Breast ca. MDA-N 
                 43.8 
                 25.7 
                 35.4 
               
               
                   
                 Ovary 
                 54.0 
                 39.5 
                 27.9 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 32.8 
                 32.3 
                 55.5 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 39.2 
                 33.0 
                 46.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 49.3 
                 35.6 
                 46.7 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 39.5 
                 20.0 
                 57.4 
               
               
                   
                 Ovarian ca. IGROV-1 
                 46.0 
                 48.0 
                 100.0 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 53.2 
                 47.6 
                 68.8 
               
               
                   
                 Uterus 
                 36.6 
                 9.9 
                 9.4 
               
               
                   
                 Placenta 
                 18.2 
                 23.8 
                 11.7 
               
               
                   
                 Prostate 
                 6.4 
                 6.7 
                 4.3 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 32.8 
                 37.6 
                 50.3 
               
               
                   
                 Testis 
                 27.7 
                 23.8 
                 4.7 
               
               
                   
                 Melanoma Hs688(A).T 
                 21.5 
                 23.0 
                 13.6 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 25.3 
                 25.3 
                 20.3 
               
               
                   
                 Melanoma UACC-62 
                 28.1 
                 23.0 
                 58.2 
               
               
                   
                 Melanoma M14 
                 34.6 
                 36.1 
                 22.2 
               
               
                   
                 Melanoma LOX IMVI 
                 100.0 
                 100.0 
                 12.2 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 12.1 
                 10.9 
                 14.3 
               
               
                   
                 Melanoma SK-MEL-28 
                 53.6 
                 79.0 
                 2.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag271, Run 87588589    
               
               
                   
                   Column B - Rel. Exp. (%) Ag271, Run 88706798    
               
               
                   
                   Column C - Rel. Exp. (%) Ag271b, Run 97805788    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE LE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2.2 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 13.7 
               
               
                   
                 Colon cancer (OD06064) 
                 45.4 
               
               
                   
                 Colon Margin (OD06064) 
                 6.7 
               
               
                   
                 Colon cancer (OD06159) 
                 1.7 
               
               
                   
                 Colon Margin (OD06159) 
                 7.0 
               
               
                   
                 Colon cancer (OD06297-04) 
                 5.3 
               
               
                   
                 Colon Margin (OD06297-05) 
                 7.4 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 10.5 
               
               
                   
                 CC Margin (ODO3921) 
                 13.3 
               
               
                   
                 Colon cancer metastasis (OD06104) 
                 1.8 
               
               
                   
                 Lung Margin (OD06104) 
                 3.0 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 21.0 
               
               
                   
                 Lung Margin (OD04451-02) 
                 10.0 
               
               
                   
                 Normal Prostate 
                 2.0 
               
               
                   
                 Prostate Cancer (OD04410) 
                 3.9 
               
               
                   
                 Prostate Margin (OD04410) 
                 10.3 
               
               
                   
                 Normal Ovary 
                 78.5 
               
               
                   
                 Ovarian cancer (OD06283-03) 
                 14.3 
               
               
                   
                 Ovarian Margin (OD06283-07) 
                 16.3 
               
               
                   
                 Ovarian Cancer 064008 
                 41.8 
               
               
                   
                 Ovarian cancer (OD06145) 
                 36.6 
               
               
                   
                 Ovarian Margin (OD06145) 
                 33.7 
               
               
                   
                 Ovarian cancer (OD06455-03) 
                 6.0 
               
               
                   
                 Ovarian Margin (OD06455-07) 
                 18.7 
               
               
                   
                 Normal Lung 
                 20.7 
               
               
                   
                 Invasive poor diff. lung adeno (ODO4945-01 
                 3.1 
               
               
                   
                 Lung Margin (ODO4945-03) 
                 10.6 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 5.8 
               
               
                   
                 Lung Margin (OD03126) 
                 10.4 
               
               
                   
                 Lung Cancer (OD05014A) 
                 6.2 
               
               
                   
                 Lung Margin (OD05014B) 
                 11.5 
               
               
                   
                 Lung cancer (OD06081) 
                 5.3 
               
               
                   
                 Lung Margin (OD06081) 
                 4.1 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 3.2 
               
               
                   
                 Lung Margin (OD04237-02) 
                 37.9 
               
               
                   
                 Ocular Melanoma Metastasis 
                 18.8 
               
               
                   
                 Ocular Melanoma Margin (Liver) 
                 8.3 
               
               
                   
                 Melanoma Metastasis 
                 40.1 
               
               
                   
                 Melanoma Margin (Lung) 
                 13.5 
               
               
                   
                 Normal Kidney 
                 16.0 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 57.0 
               
               
                   
                 Kidney Margin (OD04338) 
                 12.9 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 73.2 
               
               
                   
                 Kidney Margin (OD04339) 
                 14.2 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 20.0 
               
               
                   
                 Kidney Margin (OD04340) 
                 35.1 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 25.0 
               
               
                   
                 Kidney Margin (OD04348) 
                 100.0 
               
               
                   
                 Kidney malignant cancer (OD06204B) 
                 6.1 
               
               
                   
                 Kidney normal adjacent tissue (OD06204E) 
                 12.3 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 68.8 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 24.0 
               
               
                   
                 Kidney Cancer 8120613 
                 0.0 
               
               
                   
                 Kidney Margin 8120614 
                 11.7 
               
               
                   
                 Kidney Cancer 9010320 
                 15.5 
               
               
                   
                 Kidney Margin 9010321 
                 16.6 
               
               
                   
                 Kidney Cancer 8120607 
                 70.7 
               
               
                   
                 Kidney Margin 8120608 
                 11.4 
               
               
                   
                 Normal Uterus 
                 36.6 
               
               
                   
                 Uterine Cancer 064011 
                 11.7 
               
               
                   
                 Normal Thyroid 
                 1.6 
               
               
                   
                 Thyroid Cancer 064010 
                 10.2 
               
               
                   
                 Thyroid Cancer A302152 
                 9.3 
               
               
                   
                 Thyroid Margin A302153 
                 4.9 
               
               
                   
                 Normal Breast 
                 31.4 
               
               
                   
                 Breast Cancer (OD04566) 
                 3.1 
               
               
                   
                 Breast Cancer 1024 
                 0.0 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 10.2 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 19.1 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 6.0 
               
               
                   
                 Breast Cancer 064006 
                 14.2 
               
               
                   
                 Breast Cancer 9100266 
                 12.5 
               
               
                   
                 Breast Margin 9100265 
                 11.4 
               
               
                   
                 Breast Cancer A209073 
                 15.7 
               
               
                   
                 Breast Margin A2090734 
                 48.6 
               
               
                   
                 Breast cancer (OD06083) 
                 14.3 
               
               
                   
                 Breast cancer node metastasis (OD06083) 
                 15.6 
               
               
                   
                 Normal Liver 
                 4.3 
               
               
                   
                 Liver Cancer 1026 
                 12.3 
               
               
                   
                 Liver Cancer 1025 
                 12.5 
               
               
                   
                 Liver Cancer 6004-T 
                 12.4 
               
               
                   
                 Liver Tissue 6004-N 
                 3.0 
               
               
                   
                 Liver Cancer 6005-T 
                 21.0 
               
               
                   
                 Liver Tissue 6005-N 
                 26.2 
               
               
                   
                 Liver Cancer 064003 
                 2.5 
               
               
                   
                 Normal Bladder 
                 9.7 
               
               
                   
                 Bladder Cancer 1023 
                 8.4 
               
               
                   
                 Bladder Cancer A302173 
                 11.0 
               
               
                   
                 Normal Stomach 
                 22.8 
               
               
                   
                 Gastric Cancer 9060397 
                 9.9 
               
               
                   
                 Stomach Margin 9060396 
                 6.6 
               
               
                   
                 Gastric Cancer 9060395 
                 11.8 
               
               
                   
                 Stomach Margin 9060394 
                 23.7 
               
               
                   
                 Gastric Cancer 064005 
                 6.1 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Axp. (%) Ag271b, Run 175148876    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE LF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D 
               
            
           
           
               
               
            
               
                 Tissue Name 
                 A 
               
               
                   
               
            
           
           
               
               
            
               
                 Daoy- Medulloblastoma 
                 9.2 
               
               
                 TE671- Medulloblastoma 
                 3.3 
               
               
                 D283 Med- Medulloblastoma 
                 32.1 
               
               
                 PFSK-1- Primitive Neuroectodermal 
                 9.4 
               
               
                 XF-498- CNS 
                 42.3 
               
               
                 SNB-78- Glioma 
                 22.2 
               
               
                 SF-268- Glioblastoma 
                 17.2 
               
               
                 T98G- Glioblastoma 
                 32.3 
               
               
                 SK-N-SH- Neuroblastoma (metastasis) 
                 20.6 
               
               
                 SF-295- Glioblastoma 
                 12.8 
               
               
                 Cerebellum 
                 1.1 
               
               
                 Cerebellum 
                 1.2 
               
               
                 NCI-H292- Mucoepidermoid lung carcinoma 
                 12.6 
               
               
                 DMS-114- Small cell lung cancer 
                 4.1 
               
               
                 DMS-79- Small cell lung cancer 
                 0.3 
               
               
                 NCI-H146- Small cell lung cancer 
                 0.0 
               
               
                 NCI-H526- Small cell lung cancer 
                 2.8 
               
               
                 NCI-N417- Small cell lung cancer 
                 4.3 
               
               
                 NCI-H82- Small cell lung cancer 
                 6.5 
               
               
                 NCI-H157- Squamous cell lung cancer (metastasis) 
                 19.6 
               
               
                 NCI-H1155- Large cell lung cancer 
                 2.0 
               
               
                 NCI-H1299- Large cell lung cancer 
                 12.5 
               
               
                 NCI-H727- Lung carcinoid 
                 3.0 
               
               
                 NCI-UMC-11- Lung carcinoid 
                 0.0 
               
               
                 LX-1- Small cell lung cancer 
                 1.4 
               
               
                 Colo-205- Colon cancer 
                 0.0 
               
               
                 KM12- Colon cancer 
                 0.0 
               
               
                 KM20L2- Colon cancer 
                 1.5 
               
               
                 NCI-H716- Colon cancer 
                 0.0 
               
               
                 SW-48- Colon adenocarcinoma 
                 1.3 
               
               
                 SW1116- Colon adenocarcinoma 
                 0.0 
               
               
                 LS 174T- Colon adenocarcinoma 
                 0.0 
               
               
                 SW-948- Colon adenocarcinoma 
                 1.0 
               
               
                 SW-480- Colon adenocarcinoma 
                 0.4 
               
               
                 NCI-SNU-5- Gastric carcinoma 
                 4.5 
               
               
                 KATO III- Gastric carcinoma 
                 100.0 
               
               
                 NCI-SNU-16- Gastric carcinoma 
                 15.1 
               
               
                 NCI-SNU-1- Gastric carcinoma 
                 0.0 
               
               
                 RF-1- Gastric adenocarcinoma 
                 0.0 
               
               
                 RF-48- Gastric adenocarcinoma 
                 0.0 
               
               
                 MKN-45- Gastric carcinoma 
                 2.5 
               
               
                 NCI-N87- Gastric carcinoma 
                 1.9 
               
               
                 OVCAR-5- Ovarian carcinoma 
                 2.3 
               
               
                 RL95-2- Uterine carcinoma 
                 6.0 
               
               
                 HelaS3- Cervical adenocarcinoma 
                 4.0 
               
               
                 Ca Ski- Cervical epidermoid carcinoma (metastasis) 
                 11.9 
               
               
                 ES-2- Ovarian clear cell carcinoma 
                 8.8 
               
               
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 0.0 
               
               
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 0.0 
               
               
                 MEG-01- Chronic myelogenous leukemia (megokaryoblast) 
                 3.8 
               
               
                 Raji- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                 Daudi- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                 U266- B-cell plasmacytoma 
                 0.0 
               
               
                 CA46- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 0.0 
               
               
                 JM1- pre-B-cell lymphoma 
                 0.0 
               
               
                 Jurkat- T cell leukemia 
                 5.6 
               
               
                 TF-1- Erythroleukemia 
                 0.0 
               
               
                 HUT 78- T-cell lymphoma 
                 0.3 
               
               
                 U937- Histiocytic lymphoma 
                 0.0 
               
               
                 KU-812- Myelogenous leukemia 
                 0.2 
               
               
                 769-P- Clear cell renal carcinoma 
                 42.3 
               
               
                 Caki-2- Clear cell renal carcinoma 
                 26.6 
               
               
                 SW 839- Clear cell renal carcinoma 
                 30.1 
               
               
                 Rhabdoid kidney tumor 
                 11.5 
               
               
                 Hs766T- Pancreatic carcinoma (LN metastasis) 
                 23.7 
               
               
                 CAPAN-1- Pancreatic adenocarcinoma (liver metastasis) 
                 3.8 
               
               
                 SU86.86- Pancreatic carcinoma (liver metastasis) 
                 10.7 
               
               
                 BxPC-3- Pancreatic adenocarcinoma 
                 6.0 
               
               
                 HPAC- Pancreatic adenocarcinoma 
                 2.4 
               
               
                 MIA PaCa-2- Pancreatic carcinoma 
                 5.1 
               
               
                 CFPAC-1- Pancreatic ductal adenocarcinoma: 
                 26.1 
               
               
                 PANC-1- Pancreatic epithelioid ductal carcinoma 
                 21.2 
               
               
                 T24- Bladder carcinma (transitional cell) 
                 15.2 
               
               
                 5637- Bladder carcinoma 
                 6.3 
               
               
                 HT-1197- Bladder carcinoma 
                 1.0 
               
               
                 UM-UC-3- Bladder carcinma (transitional cell) 
                 3.7 
               
               
                 A204- Rhabdomyosarcoma 
                 6.7 
               
               
                 HT-1080- Fibrosarcoma 
                 25.5 
               
               
                 MG-63- Osteosarcoma 
                 16.5 
               
               
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 11.2 
               
               
                 SJRH30- Rhabdomyosarcoma (met to bone marrow) 
                 4.7 
               
               
                 A431- Epidermoid carcinoma 
                 4.5 
               
               
                 WM266-4- Melanoma 
                 22.1 
               
               
                 DU 145- Prostate carcinoma (brain metastasis) 
                 1.6 
               
               
                 MDA-MB-468- Breast adenocarcinoma 
                 10.6 
               
               
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.7 
               
               
                 SCC-9- Squamous cell carcinoma of tongue 
                 0.3 
               
               
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.3 
               
               
                 CAL 27- Squamous cell carcinoma of tongue 
                 10.4 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag271b, Run 182114260    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE LG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.4 
               
               
                   
                 Secondary Tr1 act 
                 0.3 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.6 
               
               
                   
                 Primary Th1 rest 
                 0.3 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 33.9 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.1 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.1 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.1 
               
               
                   
                 Two Way MLR 7 day 
                 0.3 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.3 
               
               
                   
                 EOL-1 dbcAMP 
                 0.3 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.6 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 18.2 
               
               
                   
                 HUVEC starved 
                 27.0 
               
               
                   
                 HUVEC IL-1 beta 
                 21.0 
               
               
                   
                 HUVEC IFN gamma 
                 19.2 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 26.6 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 32.5 
               
               
                   
                 HUVEC IL-11 
                 11.8 
               
               
                   
                 Lung Microvascular EC none 
                 43.2 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 34.4 
               
               
                   
                 Microvascular Dermal EC none 
                 35.8 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 26.4 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 32.3 
               
               
                   
                 Small airway epithelium none 
                 16.8 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 33.2 
               
               
                   
                 Coronery artery SMC rest 
                 47.3 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 51.8 
               
               
                   
                 Astrocytes rest 
                 59.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 38.7 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.6 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 1.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 36.1 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 30.6 
               
               
                   
                 Liver cirrhosis 
                 4.4 
               
               
                   
                 NCI-H292 none 
                 12.7 
               
               
                   
                 NCI-H292 IL-4 
                 17.3 
               
               
                   
                 NCI-H292 IL-9 
                 17.3 
               
               
                   
                 NCI-H292 IL-13 
                 17.9 
               
               
                   
                 NCI-H292 IFN gamma 
                 12.8 
               
               
                   
                 HPAEC none 
                 17.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 39.8 
               
               
                   
                 Lung fibroblast none 
                 71.7 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 55.5 
               
               
                   
                 Lung fibroblast IL-4 
                 66.4 
               
               
                   
                 Lung fibroblast IL-9 
                 100.0 
               
               
                   
                 Lung fibroblast IL-13 
                 52.1 
               
               
                   
                 Lung fibroblast IFN gamma 
                 70.7 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 66.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 61.1 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 61.6 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 43.2 
               
               
                   
                 Dermal fibroblast IL-4 
                 59.0 
               
               
                   
                 Dermal Fibroblasts rest 
                 36.6 
               
               
                   
                 Neutrophils TNFa + LPS 
                 2.0 
               
               
                   
                 Neutrophils rest 
                 6.7 
               
               
                   
                 Colon 
                 4.4 
               
               
                   
                 Lung 
                 20.4 
               
               
                   
                 Thymus 
                 11.6 
               
               
                   
                 Kidney 
                 26.6 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag271b, Run 174261189    
               
            
           
         
       
     
      General_screeningpanel_v1.4 Summary: Ag271/271b Highest expression of this gene was detected in a sample derived from a brain cancer cell line (SNB-75) (CTs=24). There was substantial expression in a number of brain cancer cell lines, renal cancer cell lines, breast cancer cell lines, ovarian cancer cell lines and melanoma cell lines. The expression of this gene is useful for the differentiation of SNB-75 cells from the other samples in the panel. Therapeutic modulation of this gene or gene product, through the use of small molecule drugs, antibodies or protein therapeutics is beneficial for the treatment of brain, renal, ovarian, breast cancers or melanoma.  
      This gene also had moderate and widespread expression in metabolic tissues including adipose, adult and fetal heart, adult and fetal skeletal muscle, adrenal, thyroid and pancreas. This gene or gene product is an antibody, protein or small molecule target for the treatment of metabolic and endocrine disease, including obesity and Types 1 and 2 diabetes. This gene was differentially expressed in fetal (CTs=29-30) vs adult liver (CTs=33) and expression of this gene or its protein product is useful differentiate between the two sources of this tissue. The higher levels of expression in fetal liver demonstrate that this gene product is involved in the development of the liver and that this gene or gene product is useful in restoring mass or function to the adult liver.  
      This panel also showed low but significant levels of expression of this gene in the CNS. Please see panel 1 for a discussion of utility of this gene in the central nervous system.  
      Panel 1 Summary: Ag271/Ag271b Highest expression of this gene was detected in a number of cancer cell lines, including ovarian cancer, pancreatic cancer, prostate cancer, melanoma, renal carcinoma, and CNS cancers, when compared to normal controls. The data presented in panel 1 showed that this gene was expressed highly in samples derived from cancer cell lines and not highly expressed in samples derived from normal tissues. Within the normal kidney samples there was a consistent difference between adult and fetal tissues. Since cell lines and fetal tissues are more proliferative than normal tissues, this expression profile demonstrates that this gene or its protein product is involved in cell proliferation. Inhibition of expression or function of this gene or gene product is a therapeutic avenue for the treatment of cancer or other disease that involve cell proliferation. Therapeutic targeting of this gene or gene product with a monoclonal antibody, protein therapeutic or small molecule will limit or block the extent of tumor cell migration and invasion and tumor metastasis, particularly in melanomas, prostate cancers, pancreatic cancers, ovarian cancers, renal cell carcinomas and CNS cancers. This gene is also be an effective marker for the diagnosis and detection of a variety of cancers.  
      This gene was also expressed in all CNS tissues examined, but at lower levels than the relatively high expression in all cancer cell lines examined and fetal kidney. This further demonstrates that this gene or its gene product is involved in the cell cycle or cell proliferation because the majority of cells in the CNS are post-mitotic. This gene is useful in stem cell research or therapy in controlling the transition from stem cell to post-mitotic differentiated cell and is of benefit in any disease associated with neuron loss such as Alzheimer&#39;s, Parkinson&#39;s, or Huntington&#39;s diseases, stroke, head trauma, spinal cord trauma, or spinocerebellar ataxia.  
      Panel 2.2 Summary: Ag271b Highest expression of this gene was seen in normal kidney. Significant expression was also seen in kidney cancer, melanoma and colon cancer when compared to normal adjacent tissue. Expression of this gene is useful in differentiating between these samples and other samples on this panel and as a marker for these cancers. Therapeutic targeting of this gene or its protein product with a monoclonal antibody, small molecule, or protein therapeutic will limit or block the extent of tumor cell migration and invasion and tumor metastasis in these tumors.  
      Panel 3D Summary: Ag271b Expression of this gene was highest in a gastric cancer cell line. Expression of this gene was detected in a number of cancer cell lines, a result that is consistent with the expression in Panel 1. This gene plays a role in cell proliferation. Inhibition of the expression or function of this gene or gene product is a therapeutic avenue for the treatment of cancer or other disease that involve cell proliferation.  
      Panel 4.1D Summary: Ag271b This gene, which encodes the extracellular domain of an immunoglobin domain containing membrane protein, was expressed in panel 4.1D in the following resting and cytokine-activated cells and tissues: HUVEC, lung microvascular endothelial cells, small airway epithelium, coronary artery smooth muscle cells, astrocytes, lung fibroblasts, and dermal fibroblasts. This gene or its gene product is useful as a target for therapeutic antibodies, small molecules or protein drugs which antagonize the function of the Ig domain-containing protein and reduce or eliminate the symptoms in patients with inflammatory diseases and autoimmune diseases, such as multiple sclerosis, chronic obstructive pulmonary disease, asthma, emphysema, rheumatoid arthritis, or psoriasis.  
      M. CG51622-01: Von Ebner Minor Salivary Gland Protein  
      Expression of gene CG51622-01 was assessed using the primer-probe set Ag719, described in Table MA. Results of the RTQ-PCR runs are shown in Tables MB and MC.  
                   TABLE MA                          Probe Name Ag719                                                     Start   SEQ ID           Primers   Sequences   Length   Position   No                                             Forward   5′-ccaggctgaaggtcatcac-3′   19   260   1309                   Probe   TET-5′-ctaacatcctccagctgcaggtgaag-3′-   26   281   1310           TAMRA               Reverse   5′-gactagcagctcctggtcatt-3′   21   316   1311                  
 
     
       
         
           
               
             
               
                 TABLE MB 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.2 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
                 C 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Endothelial cells 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Heart (Fetal) 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Pancreas 
                 0.1 
                 0.0 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Adrenal Gland 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Thyroid 
                 0.1 
                 0.0 
                 0.0 
               
               
                   
                 Salivary gland 
                 1.6 
                 0.8 
                 1.8 
               
               
                   
                 Pituitary gland 
                 0.3 
                 0.0 
                 0.0 
               
               
                   
                 Brain (fetal) 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Brain (whole) 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Brain (amygdala) 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Brain (cerebellum) 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Brain (hippocampus) 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Brain (thalamus) 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Cerebral Cortex 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Spinal cord 
                 0.1 
                 0.0 
                 0.1 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 glioma SNB-19 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 glioma U251 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 glioma SF-295 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Heart 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Skeletal Muscle 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Bone marrow 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Thymus 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Spleen 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lymph node 
                 0.3 
                 0.1 
                 0.2 
               
               
                   
                 Colorectal Tissue 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Stomach 
                 2.3 
                 3.4 
                 7.3 
               
               
                   
                 Small intestine 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca.* SW620 (SW480 met) 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. Tissue (ODO3866) 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HCC-2998 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.1 
                 0.0 
                 0.1 
               
               
                   
                 Bladder 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Trachea 
                 100.0 
                 100.0 
                 100.0 
               
               
                   
                 Kidney 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Kidney (fetal) 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Liver (fetal) 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung 
                 5.2 
                 2.3 
                 4.9 
               
               
                   
                 Lung (fetal) 
                 1.0 
                 0.3 
                 0.6 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.1 
                 0.0 
                 0.1 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.3 
                 0.1 
                 0.4 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Mammary gland 
                 0.1 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Ovary 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.9 
                 0.3 
                 0.4 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Uterus 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Placenta 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Prostate 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Testis 
                 0.2 
                 0.0 
                 0.1 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 0.1 
                 0.0 
                 0.1 
               
               
                   
                 Melanoma M14 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag719, Run 115164487    
               
               
                   
                   Column B - Rel. Exp. (%) Ag719, Run 123273033    
               
               
                   
                   Column C - Rel. Exp. (%) Ag719, Run 124111545    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE MC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Secondary Th1 act 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 act 
                 0.0 
                 0.3 
               
               
                 Secondary Tr1 act 
                 0.0 
                 0.0 
               
               
                 Secondary Th1 rest 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 rest 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 rest 
                 0.0 
                 0.0 
               
               
                 Primary Th1 act 
                 0.5 
                 0.0 
               
               
                 Primary Th2 act 
                 0.5 
                 0.0 
               
               
                 Primary Tr1 act 
                 0.0 
                 0.0 
               
               
                 Primary Th1 rest 
                 0.3 
                 0.0 
               
               
                 Primary Th2 rest 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 rest 
                 0.0 
                 0.0 
               
               
                 CD45RA CD4 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD45RO CD4 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte rest 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte act 
                 0.2 
                 0.0 
               
               
                 CD4 lymphocyte none 
                 0.0 
                 0.0 
               
               
                 2ry Th1/Th2/TM_anti-CD95 CH11 
                 0.0 
                 0.0 
               
               
                 LAK cells rest 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 
                 0.2 
                 0.0 
               
               
                 LAK cells IL-2 + IL-12 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IFN gamma 
                 0.3 
                 0.2 
               
               
                 LAK cells IL-2 + IL-18 
                 0.0 
                 0.0 
               
               
                 LAK cells PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                 NK Cells IL-2 rest 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 3 day 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 5 day 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 7 day 
                 0.0 
                 0.0 
               
               
                 PBMC rest 
                 0.0 
                 0.0 
               
               
                 PBMC PWM 
                 0.0 
                 0.0 
               
               
                 PBMC PHA-L 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) none 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
               
               
                 B lymphocytes PWM 
                 0.0 
                 0.0 
               
               
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                 Dendritic cells none 
                 0.0 
                 0.0 
               
               
                 Dendritic cells LPS 
                 0.0 
                 0.0 
               
               
                 Dendritic cells anti-CD40 
                 0.0 
                 0.0 
               
               
                 Monocytes rest 
                 0.0 
                 0.0 
               
               
                 Monocytes LPS 
                 0.3 
                 0.0 
               
               
                 Macrophages rest 
                 0.0 
                 0.0 
               
               
                 Macrophages LPS 
                 0.0 
                 0.0 
               
               
                 HUVEC none 
                 0.0 
                 0.0 
               
               
                 HUVEC starved 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-1beta 
                 0.0 
                 0.0 
               
               
                 HUVEC IFN gamma 
                 0.0 
                 0.5 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 0.5 
                 0.0 
               
               
                 HUVEC TNF alpha + IL4 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-11 
                 0.0 
                 0.0 
               
               
                 Lung Microvascular EC none 
                 0.0 
                 0.0 
               
               
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Microvascular Dermal EC none 
                 0.0 
                 0.0 
               
               
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.3 
                 0.0 
               
               
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
                 0.0 
               
               
                 Small airway epithelium none 
                 0.0 
                 0.0 
               
               
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Coronery artery SMC rest 
                 0.0 
                 0.0 
               
               
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Astrocytes rest 
                 0.0 
                 0.0 
               
               
                 Astrocytes TNFalpha + IL-1 beta 
                 0.5 
                 0.0 
               
               
                 KU-812 (Basophil) rest 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) none 
                 0.0 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.3 
                 0.0 
               
               
                 Liver cirrhosis 
                 1.6 
                 1.9 
               
               
                 Lupus kidney 
                 0.3 
                 0.0 
               
               
                 NCI-H292 none 
                 88.9 
                 86.5 
               
               
                 NCI-H292 IL-4 
                 64.2 
                 56.6 
               
               
                 NCI-H292 IL-9 
                 68.8 
                 55.1 
               
               
                 NCI-H292 IL-13 
                 47.0 
                 53.2 
               
               
                 NCI-H292 IFN gamma 
                 30.6 
                 19.2 
               
               
                 HPAEC none 
                 0.0 
                 0.0 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast none 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.2 
                 0.0 
               
               
                 Lung fibroblast IL-4 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-9 
                 0.1 
                 0.0 
               
               
                 Lung fibroblast IL-13 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 rest 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast IL-4 
                 0.0 
                 0.0 
               
               
                 IBD Colitis 2 
                 0.0 
                 0.0 
               
               
                 IBD Crohn&#39;s 
                 1.3 
                 0.4 
               
               
                 Colon 
                 0.3 
                 1.4 
               
               
                 Lung 
                 100.0 
                 100.0 
               
               
                 Thymus 
                 1.0 
                 0.0 
               
               
                 Kidney 
                 0.8 
                 0.8 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag719, Run 138167117    
               
               
                   Column B - Rel. Exp. (%) Ag719, Run 138273090    
               
            
           
         
       
     
      Panel 1.2 Summary: Ag719 Highest expression of this gene was detected in the trachea (CTs=18-19). Low to moderate expression was also seen in a few cancer cell lines derived from melanoma, lung, and ovarian cancers. Low expression of this gene is also seen in stomach, pancreas, lung, mammary gland, bladder and spinal cord.  
      Panel 4D Summary: Ag719 Highest expression of this gene was detected in lung (CTs=28-29). Moderate expression of this gene was also seen in resting and activated NCI-H292.  
      N. CG51622-03: Von Ebner Minor Salivary Gland Protein  
      Expression of gene CG51622-03 was assessed using the primer-probe set Ag5814, described in Table NA. Results of the RTQ-PCR runs are shown in Table NB.  
                   TABLE NA                          Probe Name Ag5814                                                     Start   SEQ ID           Primers   Sequences   Length   Position   No                                             Forward   5′-ccaggagctgctagtcaaga-3′   20   358   1312                   Probe   TET-5′-ctggattcaacacgctctccttcctg-3′-   26   396   1313           TAMRA               Reverse   5′-aggaggttcatgacctgctt-3′   20   437   1314                  
 
     
       
         
           
               
             
               
                 TABLE NB 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.5 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 0.0 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma* M14 
                 0.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.0 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.0 
               
               
                   
                 Testis Pool 
                 0.2 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate Pool 
                 0.1 
               
               
                   
                 Placenta 
                 0.0 
               
               
                   
                 Uterus Pool 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 4.2 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
               
               
                   
                 Ovary 
                 9.0 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca. BT 549 
                 0.0 
               
               
                   
                 Breast ca. T47D 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Breast Pool 
                 0.0 
               
               
                   
                 Trachea 
                 100.0 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Fetal Lung 
                 0.0 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.0 
               
               
                   
                 Lung ca. A549 
                 0.1 
               
               
                   
                 Lung ca. NCI-H526 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 0.0 
               
               
                   
                 Lung ca. NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. HOP-62 
                 0.0 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 0.0 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
               
               
                   
                 Kidney Pool 
                 0.0 
               
               
                   
                 Fetal Kidney 
                 0.0 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Bladder 
                 0.0 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.2 
               
               
                   
                 Gastric ca. KATO III 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.2 
               
               
                   
                 Colon cancer tissue 
                 0.0 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 0.0 
               
               
                   
                 Small Intestine Pool 
                 0.2 
               
               
                   
                 Stomach Pool 
                 0.0 
               
               
                   
                 Bone Marrow Pool 
                 0.0 
               
               
                   
                 Fetal Heart 
                 0.0 
               
               
                   
                 Heart Pool 
                 0.0 
               
               
                   
                 Lymph Node Pool 
                 0.0 
               
               
                   
                 Fetal Skeletal Muscle 
                 0.0 
               
               
                   
                 Skeletal Muscle Pool 
                 0.0 
               
               
                   
                 Spleen Pool 
                 0.0 
               
               
                   
                 Thymus Pool 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 0.0 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.0 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 0.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.0 
               
               
                   
                 Brain (Amygdala) Pool 
                 0.0 
               
               
                   
                 Brain (cerebellum) 
                 0.0 
               
               
                   
                 Brain (fetal) 
                 0.0 
               
               
                   
                 Brain (Hippocampus) Pool 
                 0.0 
               
               
                   
                 Cerebral Cortex Pool 
                 0.0 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 0.0 
               
               
                   
                 Brain (Thalamus) Pool 
                 0.0 
               
               
                   
                 Brain (whole) 
                 0.0 
               
               
                   
                 Spinal Cord Pool 
                 0.0 
               
               
                   
                 Adrenal Gland 
                 0.0 
               
               
                   
                 Pituitary gland Pool 
                 0.0 
               
               
                   
                 Salivary Gland 
                 0.3 
               
               
                   
                 Thyroid (female) 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.2 
               
               
                   
                 Pancreas Pool 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag5814, Run 244897723    
               
            
           
         
       
     
      General_screening_panel_v1.5 Summary: Ag5814 High levels of expression of this gene were seen in the trachea (CT=27).  
      O CG51622-04: Von Ebner Minor Salivary Gland Protein  
      Expression of gene CG51622-04 was assessed using the primer-probe set Ag5210, described in Table OA. Results of the RTQ-PCR runs are shown in Table OB.  
                   TABLE OA                          Probe Name Ag5210                                                     Start   SEQ ID           Primers   Sequences   Length   Position   No                                             Forward   5′-aagaagcatgagacgcagact-3′   21   87   1315                   Probe   TET-5′-caaagaactcccagtgcaggacaatg-3′-   26   116   1316           TAMRA               Reverse   5′-actgtcctccactcccatgt-3′   20   165   1317                  
 
     
       
         
           
               
             
               
                 TABLE OB 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.5 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 0.0 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma* M14 
                 0.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.0 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.0 
               
               
                   
                 Testis Pool 
                 2.0 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate Pool 
                 0.0 
               
               
                   
                 Placenta 
                 0.0 
               
               
                   
                 Uterus Pool 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 7.3 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
               
               
                   
                 Ovary 
                 9.9 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca. BT 549 
                 0.0 
               
               
                   
                 Breast ca. T47D 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Breast Pool 
                 0.0 
               
               
                   
                 Trachea 
                 100.0 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Fetal Lung 
                 0.5 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.0 
               
               
                   
                 Lung ca. A549 
                 0.5 
               
               
                   
                 Lung ca. NCI-H526 
                 0.5 
               
               
                   
                 Lung ca. NCI-H23 
                 0.0 
               
               
                   
                 Lung ca. NCI-H460 
                 7.7 
               
               
                   
                 Lung ca. HOP-62 
                 0.0 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 0.0 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
               
               
                   
                 Kidney Pool 
                 0.0 
               
               
                   
                 Fetal Kidney 
                 0.0 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Bladder 
                 0.0 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.9 
               
               
                   
                 Gastric ca. KATO III 
                 0.2 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon cancer tissue 
                 0.0 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 0.0 
               
               
                   
                 Small Intestine Pool 
                 0.2 
               
               
                   
                 Stomach Pool 
                 0.2 
               
               
                   
                 Bone Marrow Pool 
                 1.3 
               
               
                   
                 Fetal Heart 
                 0.0 
               
               
                   
                 Heart Pool 
                 0.0 
               
               
                   
                 Lymph Node Pool 
                 0.0 
               
               
                   
                 Fetal Skeletal Muscle 
                 0.0 
               
               
                   
                 Skeletal Muscle Pool 
                 0.0 
               
               
                   
                 Spleen Pool 
                 0.0 
               
               
                   
                 Thymus Pool 
                 0.2 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 0.5 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.0 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 0.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.0 
               
               
                   
                 Brain (Amygdala) Pool 
                 0.0 
               
               
                   
                 Brain (cerebellum) 
                 0.3 
               
               
                   
                 Brain (fetal) 
                 0.1 
               
               
                   
                 Brain (Hippocampus) Pool 
                 0.2 
               
               
                   
                 Cerebral Cortex Pool 
                 0.3 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 0.2 
               
               
                   
                 Brain (Thalamus) Pool 
                 0.0 
               
               
                   
                 Brain (whole) 
                 0.9 
               
               
                   
                 Spinal Cord Pool 
                 0.0 
               
               
                   
                 Adrenal Gland 
                 0.0 
               
               
                   
                 Pituitary gland Pool 
                 0.0 
               
               
                   
                 Salivary Gland 
                 0.2 
               
               
                   
                 Thyroid (female) 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.8 
               
               
                   
                 Pancreas Pool 
                 0.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag5210, Run 228727456    
               
            
           
         
       
     
      General_screening_panel_v1.5 Summary: Ag5210 Moderate expression was seen in the trachea (CT=30).  
      P. CG51622-05: Von Ebner Minor Salivary Gland Protein  
      Expression of gene CG51622-05 was assessed using the primer-probe set Ag5103, described in Table PA. Results of the RTQ-PCR runs are shown in Tables PB, PC, PD and PE.  
                   TABLE PA                          Probe Name Ag5103                                                     Start   SEQ ID           Primers   Sequences   Length   Position   No                                             Forward   5′-agtgaaaaaccagctggtgaa-3′   21   661   1318                   Probe   TET-5′-catttccctcagcattgaccgtctg-3′-   25   688   1319           TAMRA               Reverse   5′-ggcaggatacagaaggtcaaa-3′   21   716   1320                  
 
     
       
         
           
               
             
               
                 TABLE PB 
               
             
            
               
                   
               
               
                   
               
               
                 AI_comprehensive panel_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 110967 COPD-F 
                 0.0 
               
               
                   
                 110980 COPD-F 
                 0.0 
               
               
                   
                 110968 COPD-M 
                 0.0 
               
               
                   
                 110977 COPD-M 
                 0.0 
               
               
                   
                 110989 Emphysema-F 
                 0.0 
               
               
                   
                 110992 Emphysema-F 
                 0.6 
               
               
                   
                 110993 Emphysema-F 
                 0.0 
               
               
                   
                 110994 Emphysema-F 
                 0.0 
               
               
                   
                 110995 Emphysema-F 
                 0.0 
               
               
                   
                 110996 Emphysema-F 
                 0.0 
               
               
                   
                 110997 Asthma-M 
                 9.2 
               
               
                   
                 111001 Asthma-F 
                 0.0 
               
               
                   
                 111002 Asthma-F 
                 0.0 
               
               
                   
                 111003 Atopic Asthma-F 
                 0.0 
               
               
                   
                 111004 Atopic Asthma-F 
                 0.0 
               
               
                   
                 111005 Atopic Asthma-F 
                 0.0 
               
               
                   
                 111006 Atopic Asthma-F 
                 0.0 
               
               
                   
                 111417 Allergy-M 
                 0.0 
               
               
                   
                 112347 Allergy-M 
                 0.0 
               
               
                   
                 112349 Normal Lung-F 
                 0.0 
               
               
                   
                 112357 Normal Lung-F 
                 0.0 
               
               
                   
                 112354 Normal Lung-M 
                 0.0 
               
               
                   
                 112374 Crohns-F 
                 0.0 
               
               
                   
                 112389 Match Control Crohns-F 
                 0.0 
               
               
                   
                 112375 Crohns-F 
                 0.0 
               
               
                   
                 112732 Match Control Crohns-F 
                 0.0 
               
               
                   
                 112725 Crohns-M 
                 0.0 
               
               
                   
                 112387 Match Control Crohns-M 
                 0.0 
               
               
                   
                 112378 Crohns-M 
                 0.0 
               
               
                   
                 112390 Match Control Crohns-M 
                 0.0 
               
               
                   
                 112726 Crohns-M 
                 0.0 
               
               
                   
                 112731 Match Control Crohns-M 
                 6.3 
               
               
                   
                 112380 Ulcer Col-F 
                 0.0 
               
               
                   
                 112734 Match Control Ulcer Col-F 
                 54.0 
               
               
                   
                 112384 Ulcer Col-F 
                 0.0 
               
               
                   
                 112737 Match Control Ulcer Col-F 
                 0.0 
               
               
                   
                 112386 Ulcer Col-F 
                 0.0 
               
               
                   
                 112738 Match Control Ulcer Col-F 
                 0.0 
               
               
                   
                 112381 Ulcer Col-M 
                 0.0 
               
               
                   
                 112735 Match Control Ulcer Col-M 
                 0.0 
               
               
                   
                 112382 Ulcer Col-M 
                 0.0 
               
               
                   
                 112394 Match Control Ulcer Col-M 
                 0.0 
               
               
                   
                 112383 Ulcer Col-M 
                 0.0 
               
               
                   
                 112736 Match Control Ulcer Col-M 
                 0.0 
               
               
                   
                 112423 Psoriasis-F 
                 0.0 
               
               
                   
                 112427 Match Control Psoriasis-F 
                 0.0 
               
               
                   
                 112418 Psoriasis-M 
                 0.0 
               
               
                   
                 112723 Match Control Psoriasis-M 
                 0.0 
               
               
                   
                 112419 Psoriasis-M 
                 0.0 
               
               
                   
                 112424 Match Control Psoriasis-M 
                 0.0 
               
               
                   
                 112420 Psoriasis-M 
                 0.0 
               
               
                   
                 112425 Match Control Psoriasis-M 
                 0.0 
               
               
                   
                 104689 (MF) OA Bone-Backus 
                 0.0 
               
               
                   
                 104690 (MF) Adj “Normal” Bone-Backus 
                 0.0 
               
               
                   
                 104691 (MF) OA Synovium-Backus 
                 0.0 
               
               
                   
                 104692 (BA) OA Cartilage-Backus 
                 0.0 
               
               
                   
                 104694 (BA) OA Bone-Backus 
                 0.0 
               
               
                   
                 104695 (BA) Adj “Normal” Bone-Backus 
                 0.0 
               
               
                   
                 104696 (BA) OA Synovium-Backus 
                 0.0 
               
               
                   
                 104700 (SS) OA Bone-Backus 
                 0.0 
               
               
                   
                 104701 (SS) Adj “Normal” Bone-Backus 
                 0.0 
               
               
                   
                 104702 (SS) OA Synovium-Backus 
                 0.0 
               
               
                   
                 117093 OA Cartilage Rep7 
                 0.0 
               
               
                   
                 112672 OA Bone5 
                 0.0 
               
               
                   
                 112673 OA Synovium5 
                 0.0 
               
               
                   
                 112674 OA Synovial Fluid cells5 
                 0.0 
               
               
                   
                 117100 OA Cartilage Rep14 
                 0.0 
               
               
                   
                 112756 OA Bone9 
                 0.0 
               
               
                   
                 112757 OA Synovium9 
                 0.0 
               
               
                   
                 112758 OA Synovial Fluid Cells9 
                 0.0 
               
               
                   
                 117125 RA Cartilage Rep2 
                 0.0 
               
               
                   
                 113492 Bone2 RA 
                 100.0 
               
               
                   
                 113493 Synovium2 RA 
                 35.6 
               
               
                   
                 113494 Syn Fluid Cells RA 
                 53.6 
               
               
                   
                 113499 Cartilage4 RA 
                 4.0 
               
               
                   
                 113500 Bone4 RA 
                 2.7 
               
               
                   
                 113501 Synovium4 RA 
                 1.0 
               
               
                   
                 113502 Syn Fluid Cells4 RA 
                 0.9 
               
               
                   
                 113495 Cartilage3 RA 
                 6.0 
               
               
                   
                 113496 Bone3 RA 
                 3.2 
               
               
                   
                 113497 Synovium3 RA 
                 4.4 
               
               
                   
                 113498 Syn Fluid Cells3 RA 
                 6.3 
               
               
                   
                 117106 Normal Cartilage Rep20 
                 0.0 
               
               
                   
                 113663 Bone3 Normal 
                 0.0 
               
               
                   
                 113664 Synovium3 Normal 
                 0.0 
               
               
                   
                 113665 Syn Fluid Cells3 Normal 
                 0.0 
               
               
                   
                 117107 Normal Cartilage Rep22 
                 0.0 
               
               
                   
                 113667 Bone4 Normal 
                 0.0 
               
               
                   
                 113668 Synovium4 Normal 
                 0.0 
               
               
                   
                 113669 Syn Fluid Cells4 Normal 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag5103, Run 229314009    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE PC 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.5 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 0.0 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma* M14 
                 0.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.0 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.0 
               
               
                   
                 Testis Pool 
                 0.0 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate Pool 
                 0.0 
               
               
                   
                 Placenta 
                 0.0 
               
               
                   
                 Uterus Pool 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.5 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
               
               
                   
                 Ovary 
                 3.6 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca. BT 549 
                 0.0 
               
               
                   
                 Breast ca. T47D 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Breast Pool 
                 0.0 
               
               
                   
                 Trachea 
                 100.0 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Fetal Lung 
                 0.2 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.0 
               
               
                   
                 Lung ca. A549 
                 0.0 
               
               
                   
                 Lung ca. NCI-H526 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 0.0 
               
               
                   
                 Lung ca. NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. HOP-62 
                 0.0 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 0.0 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
               
               
                   
                 Kidney Pool 
                 0.0 
               
               
                   
                 Fetal Kidney 
                 0.0 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Bladder 
                 0.0 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.1 
               
               
                   
                 Gastric ca. KATO III 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon cancer tissue 
                 0.0 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 0.0 
               
               
                   
                 Small Intestine Pool 
                 0.0 
               
               
                   
                 Stomach Pool 
                 0.0 
               
               
                   
                 Bone Marrow Pool 
                 0.1 
               
               
                   
                 Fetal Heart 
                 0.0 
               
               
                   
                 Heart Pool 
                 0.0 
               
               
                   
                 Lymph Node Pool 
                 0.0 
               
               
                   
                 Fetal Skeletal Muscle 
                 0.0 
               
               
                   
                 Skeletal Muscle Pool 
                 0.0 
               
               
                   
                 Spleen Pool 
                 0.0 
               
               
                   
                 Thymus Pool 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 0.0 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.0 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 0.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.0 
               
               
                   
                 Brain (Amygdala) Pool 
                 0.0 
               
               
                   
                 Brain (cerebellum) 
                 0.0 
               
               
                   
                 Brain (fetal) 
                 0.0 
               
               
                   
                 Brain (Hippocampus) Pool 
                 0.0 
               
               
                   
                 Cerebral Cortex Pool 
                 0.0 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 0.0 
               
               
                   
                 Brain (Thalamus) Pool 
                 0.0 
               
               
                   
                 Brain (whole) 
                 0.0 
               
               
                   
                 Spinal Cord Pool 
                 0.0 
               
               
                   
                 Adrenal Gland 
                 0.0 
               
               
                   
                 Pituitary gland Pool 
                 0.0 
               
               
                   
                 Salivary Gland 
                 0.2 
               
               
                   
                 Thyroid (female) 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.0 
               
               
                   
                 Pancreas Pool 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag5103, Run 228753956    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE PD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.0 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.0 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
               
               
                   
                 Small airway epithelium none 
                 0.0 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Coronery artery SMC rest 
                 0.0 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.9 
               
               
                   
                 Astrocytes rest 
                 0.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Liver cirrhosis 
                 0.0 
               
               
                   
                 NCI-H292 none 
                 14.7 
               
               
                   
                 NCI-H292 IL-4 
                 23.0 
               
               
                   
                 NCI-H292 IL-9 
                 33.2 
               
               
                   
                 NCI-H292 IL-13 
                 13.2 
               
               
                   
                 NCI-H292 IFN gamma 
                 9.6 
               
               
                   
                 HPAEC none 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 0.0 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast IL-4 
                 0.0 
               
               
                   
                 Lung fibroblast IL-9 
                 0.0 
               
               
                   
                 Lung fibroblast IL-13 
                 0.0 
               
               
                   
                 Lung fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 100.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 0.0 
               
               
                   
                 Dermal Fibroblasts rest 
                 0.0 
               
               
                   
                 Neutrophils TNFa + LPS 
                 0.0 
               
               
                   
                 Neutrophils rest 
                 0.0 
               
               
                   
                 Colon 
                 2.0 
               
               
                   
                 Lung 
                 24.7 
               
               
                   
                 Thymus 
                 0.3 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag5103, Run 226160624    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE PE 
               
             
            
               
                   
               
               
                   
               
               
                 general oncology screening panel_v_2.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Colon cancer 1 
                 0.0 
               
               
                   
                 Colon cancer NAT 1 
                 0.0 
               
               
                   
                 Colon cancer 2 
                 0.0 
               
               
                   
                 Colon cancer NAT 2 
                 0.0 
               
               
                   
                 Colon cancer 3 
                 0.0 
               
               
                   
                 Colon cancer NAT 3 
                 0.0 
               
               
                   
                 Colon malignant cancer 4 
                 0.0 
               
               
                   
                 Colon normal adjacent tissue 4 
                 0.0 
               
               
                   
                 Lung cancer 1 
                 6.6 
               
               
                   
                 Lung NAT 1 
                 19.8 
               
               
                   
                 Lung cancer 2 
                 0.8 
               
               
                   
                 Lung NAT 2 
                 0.0 
               
               
                   
                 Squamous cell carcinoma 3 
                 16.0 
               
               
                   
                 Lung NAT 3 
                 59.0 
               
               
                   
                 metastatic melanoma 1 
                 0.0 
               
               
                   
                 Melanoma 2 
                 0.0 
               
               
                   
                 Melanoma 3 
                 0.0 
               
               
                   
                 metastatic melanoma 4 
                 8.0 
               
               
                   
                 metastatic melanoma 5 
                 100.0 
               
               
                   
                 Bladder cancer 1 
                 0.0 
               
               
                   
                 Bladder cancer NAT 1 
                 0.0 
               
               
                   
                 Bladder cancer 2 
                 0.0 
               
               
                   
                 Bladder cancer NAT 2 
                 0.0 
               
               
                   
                 Bladder cancer NAT 3 
                 0.2 
               
               
                   
                 Bladder cancer NAT 4 
                 0.0 
               
               
                   
                 Prostate adenocarcinoma 1 
                 0.0 
               
               
                   
                 Prostate adenocarcinoma 2 
                 0.0 
               
               
                   
                 Prostate adenocarcinoma 3 
                 0.0 
               
               
                   
                 Prostate adenocarcinoma 4 
                 0.4 
               
               
                   
                 Prostate cancer NAT 5 
                 0.0 
               
               
                   
                 Prostate adenocarcinoma 6 
                 0.0 
               
               
                   
                 Prostate adenocarcinoma 7 
                 0.0 
               
               
                   
                 Prostate adenocarcinoma 8 
                 0.5 
               
               
                   
                 Prostate adenocarcinoma 9 
                 2.0 
               
               
                   
                 Prostate cancer NAT 10 
                 0.0 
               
               
                   
                 Kidney cancer 1 
                 0.0 
               
               
                   
                 KidneyNAT 1 
                 0.0 
               
               
                   
                 Kidney cancer 2 
                 0.0 
               
               
                   
                 Kidney NAT 2 
                 0.0 
               
               
                   
                 Kidney cancer 3 
                 0.0 
               
               
                   
                 Kidney NAT 3 
                 0.0 
               
               
                   
                 Kidney cancer 4 
                 0.0 
               
               
                   
                 Kidney NAT 4 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A- Rel. Exp. (%) Ag5103, Run259939204    
               
            
           
         
       
     
      AI_comprehensive panel_v1.0 Summary: Ag5103 Moderate levels of expression were seen in three RA samples, with highest expression in a bone sample from an RA patient (CT=30). Therapeutics targeting of this gene or its protein product is useful for the reduction and inhibition of the inflammation in RA.  
      General_screening_panel_v1.5 Summary: Ag5103 Extremely high levels of expression were seen in the trachea (CT=23).  
      Panel 4.1D Summary: AG5103 Highest expression of this gene was detected in IFN gamma treated dermal fibroblasts (CT=31.6). Prominent expression was also seen in a cluster of treated and untreated NCI-H292 cells, a mucoepidermoid cell line. In comparison, expression in the normal lung was relatively low. The expression of the transcript in a cell line that is often used as a model for airway epithelium (NCI-H292 cells) demonstrates that this transcript is important in the proliferation or activation of airway epithelium. Therapeutics designed with the protein encoded for by the transcript are important in the treatment of diseases which include lung airway inflammation such as asthma and COPD.  
      general oncology screening panel_v — 2.4 Summary: Ag5103 Highest expression was seen in a melanoma sample (CT=31). Prominent expression was also seen in two samples derived from normal lung tissue.  
      Q. CG51821-01: Sialoadhesin  
      Expression of gene CG51821-01 was assessed using the primer-probe set Ag274, described in Table QA. Results of the RTQ-PCR runs are shown in Tables QB, QC, QD, QE, QF and QG.  
               TABLE QA                          Probe Name Ag274                                 Primers   Sequences   Length   Start Position   SEQ ID No                                             Forward   5′-cagaacagatgtattccccttggt-3′   24   4835   1321                   Probe   TET-5′-ctcagcgcctcgatgtccaccc-3′-TAMRA   22   4805   1322               Reverse   5′-ctggcttcccccaatgc-3′   17   4783   1323                  
 
     
       
         
           
               
             
               
                 TABLE QB 
               
             
            
               
                   
               
               
                   
               
               
                 AI_comprehensive panel_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 110967 COPD-F 
                 4.3 
               
               
                   
                 110980 COPD-F 
                 1.6 
               
               
                   
                 110968 COPD-M 
                 5.2 
               
               
                   
                 110977 COPD-M 
                 2.7 
               
               
                   
                 110989 Emphysema-F 
                 2.2 
               
               
                   
                 110992 Emphysema-F 
                 0.5 
               
               
                   
                 110993 Emphysema-F 
                 4.0 
               
               
                   
                 110994 Emphysema-F 
                 4.3 
               
               
                   
                 110995 Emphysema-F 
                 5.7 
               
               
                   
                 110996 Emphysema-F 
                 2.0 
               
               
                   
                 110997 Asthma-M 
                 1.6 
               
               
                   
                 111001 Asthma-F 
                 2.2 
               
               
                   
                 111002 Asthma-F 
                 4.4 
               
               
                   
                 111003 Atopic Asthma-F 
                 4.0 
               
               
                   
                 111004 Atopic Asthma-F 
                 3.6 
               
               
                   
                 111005 Atopic Asthma-F 
                 2.4 
               
               
                   
                 111006 Atopic Asthma-F 
                 0.5 
               
               
                   
                 111417 Allergy-M 
                 2.1 
               
               
                   
                 112347 Allergy-M 
                 0.1 
               
               
                   
                 112349 Normal Lung-F 
                 0.0 
               
               
                   
                 112357 Normal Lung-F 
                 8.4 
               
               
                   
                 112354 Normal Lung-M 
                 2.6 
               
               
                   
                 112374 Crohns-F 
                 4.4 
               
               
                   
                 112389 Match Control Crohns-F 
                 2.2 
               
               
                   
                 112375 Crohns-F 
                 3.9 
               
               
                   
                 112732 Match Control Crohns-F 
                 3.4 
               
               
                   
                 112725 Crohns-M 
                 0.6 
               
               
                   
                 112387 Match Control Crohns-M 
                 4.3 
               
               
                   
                 112378 Crohns-M 
                 0.2 
               
               
                   
                 112390 Match Control Crohns-M 
                 2.3 
               
               
                   
                 112726 Crohns-M 
                 3.5 
               
               
                   
                 112731 Match Control Crohns-M 
                 3.1 
               
               
                   
                 112380 Ulcer Col-F 
                 1.1 
               
               
                   
                 112734 Match Control Ulcer Col-F 
                 8.8 
               
               
                   
                 112384 Ulcer Col-F 
                 4.9 
               
               
                   
                 112737 Match Control Ulcer Col-F 
                 0.4 
               
               
                   
                 112386 Ulcer Col-F 
                 8.4 
               
               
                   
                 112738 Match Control Ulcer Col-F 
                 6.3 
               
               
                   
                 112381 Ulcer Col-M 
                 0.5 
               
               
                   
                 112735 Match Control Ulcer Col-M 
                 0.9 
               
               
                   
                 112382 Ulcer Col-M 
                 3.3 
               
               
                   
                 112394 Match Control Ulcer Col-M 
                 2.8 
               
               
                   
                 112383 Ulcer Col-M 
                 5.3 
               
               
                   
                 112736 Match Control Ulcer Col-M 
                 5.5 
               
               
                   
                 112423 Psoriasis-F 
                 2.2 
               
               
                   
                 112427 Match Control Psoriasis-F 
                 1.8 
               
               
                   
                 112418 Psoriasis-M 
                 7.8 
               
               
                   
                 112723 Match Control Psoriasis-M 
                 3.3 
               
               
                   
                 112419 Psoriasis-M 
                 4.4 
               
               
                   
                 112424 Match Control Psoriasis-M 
                 1.1 
               
               
                   
                 112420 Psoriasis-M 
                 6.2 
               
               
                   
                 112425 Match Control Psoriasis-M 
                 1.5 
               
               
                   
                 104689 (MF) OA Bone-Backus 
                 28.5 
               
               
                   
                 104690 (MF) Adj “Normal” Bone-Backus 
                 19.6 
               
               
                   
                 104691 (MF) OA Synovium-Backus 
                 100.0 
               
               
                   
                 104692 (BA) OA Cartilage-Backus 
                 0.7 
               
               
                   
                 104694 (BA) OA Bone-Backus 
                 42.3 
               
               
                   
                 104695 (BA) Adj “Normal” Bone-Backus 
                 27.4 
               
               
                   
                 104696 (BA) OA Synovium-Backus 
                 71.2 
               
               
                   
                 104700 (SS) OA Bone-Backus 
                 16.4 
               
               
                   
                 104701 (SS) Adj “Normal” Bone-Backus 
                 29.7 
               
               
                   
                 104702 (SS) OA Synovium-Backus 
                 67.8 
               
               
                   
                 117093 OA Cartilage Rep7 
                 1.8 
               
               
                   
                 112672 OA Bone5 
                 8.8 
               
               
                   
                 112673 OA Synovium5 
                 3.5 
               
               
                   
                 112674 OA Synovial Fluid cells5 
                 3.7 
               
               
                   
                 117100 OA Cartilage Rep14 
                 1.8 
               
               
                   
                 112756 OA Bone9 
                 2.5 
               
               
                   
                 112757 OA Synovium9 
                 4.7 
               
               
                   
                 112758 OA Synovial Fluid Cells9 
                 9.0 
               
               
                   
                 117125 RA Cartilage Rep2 
                 4.6 
               
               
                   
                 113492 Bone2 RA 
                 6.6 
               
               
                   
                 113493 Synovium2 RA 
                 4.4 
               
               
                   
                 113494 Syn Fluid Cells RA 
                 5.8 
               
               
                   
                 113499 Cartilage4 RA 
                 8.3 
               
               
                   
                 113500 Bone4 RA 
                 7.9 
               
               
                   
                 113501 Synovium4 RA 
                 6.9 
               
               
                   
                 113502 Syn Fluid Cells4 RA 
                 4.1 
               
               
                   
                 113495 Cartilage3 RA 
                 5.6 
               
               
                   
                 113496 Bone3 RA 
                 5.8 
               
               
                   
                 113497 Synovium3 RA 
                 4.3 
               
               
                   
                 113498 Syn Fluid Cells3 RA 
                 9.2 
               
               
                   
                 117106 Normal Cartilage Rep20 
                 2.0 
               
               
                   
                 113663 Bone3 Normal 
                 0.0 
               
               
                   
                 113664 Synovium3 Normal 
                 0.0 
               
               
                   
                 113665 Syn Fluid Cells3 Normal 
                 0.1 
               
               
                   
                 117107 Normal Cartilage Rep22 
                 1.4 
               
               
                   
                 113667 Bone4 Normal 
                 2.5 
               
               
                   
                 113668 Synovium4 Normal 
                 1.4 
               
               
                   
                 113669 Syn Fluid Cells4 Normal 
                 3.1 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag274, Run 228157466    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE QC 
               
             
            
               
                   
               
               
                   
               
               
                 General_screenmg_panel_v1.4 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Adipose 
                 20.4 
                 23.5 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.6 
                 1.5 
               
               
                   
                 Melanoma* M14 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 3.1 
                 0.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.0 
                 1.9 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 1.0 
                 0.0 
               
               
                   
                 Testis Pool 
                 5.7 
                 7.1 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
                 1.1 
               
               
                   
                 Prostate Pool 
                 1.6 
                 2.0 
               
               
                   
                 Placenta 
                 45.4 
                 51.4 
               
               
                   
                 Uterus Pool 
                 2.2 
                 1.2 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.0 
                 0.8 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
                 2.6 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.5 
                 1.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.8 
                 2.9 
               
               
                   
                 Ovary 
                 12.8 
                 9.9 
               
               
                   
                 Breast ca. MCF-7 
                 0.7 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.4 
                 2.4 
               
               
                   
                 Breast ca. BT 549 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. T47D 
                 1.0 
                 1.6 
               
               
                   
                 Breast ca. MDA-N 
                 0.6 
                 1.3 
               
               
                   
                 Breast Pool 
                 8.7 
                 6.1 
               
               
                   
                 Trachea 
                 14.3 
                 21.3 
               
               
                   
                 Lung 
                 3.8 
                 5.3 
               
               
                   
                 Fetal Lung 
                 6.7 
                 4.6 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.3 
                 0.6 
               
               
                   
                 Lung ca. NCI-H146 
                 1.0 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.8 
                 1.0 
               
               
                   
                 Lung ca. A549 
                 1.1 
                 0.0 
               
               
                   
                 Lung ca. NCI-H526 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. NCI-H460 
                 0.0 
                 1.1 
               
               
                   
                 Lung ca. HOP-62 
                 0.0 
                 5.1 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
                 0.0 
               
               
                   
                 Liver 
                 11.7 
                 13.5 
               
               
                   
                 Fetal Liver 
                 26.6 
                 26.2 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
                 0.7 
               
               
                   
                 Kidney Pool 
                 7.0 
                 13.0 
               
               
                   
                 Fetal Kidney 
                 3.1 
                 3.2 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
                 1.8 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
                 0.6 
               
               
                   
                 Bladder 
                 100.0 
                 100.0 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 2.0 
                 2.1 
               
               
                   
                 Gastric ca. KATO III 
                 0.0 
                 2.0 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 1.2 
                 0.3 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.5 
                 0.5 
               
               
                   
                 Colon ca. HT29 
                 1.3 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
                 0.8 
               
               
                   
                 Colon ca. CaCo-2 
                 1.0 
                 0.0 
               
               
                   
                 Colon cancer tissue 
                 26.4 
                 32.3 
               
               
                   
                 Colon ca. SW1116 
                 1.6 
                 0.8 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
                 1.3 
               
               
                   
                 Colon Pool 
                 12.1 
                 9.7 
               
               
                   
                 Small Intestine Pool 
                 5.3 
                 3.8 
               
               
                   
                 Stomach Pool 
                 8.1 
                 9.8 
               
               
                   
                 Bone Marrow Pool 
                 4.8 
                 7.9 
               
               
                   
                 Fetal Heart 
                 0.4 
                 1.2 
               
               
                   
                 Heart Pool 
                 5.3 
                 8.2 
               
               
                   
                 Lymph Node Pool 
                 8.8 
                 11.7 
               
               
                   
                 Fetal Skeletal Muscle 
                 5.0 
                 5.5 
               
               
                   
                 Skeletal Muscle Pool 
                 12.2 
                 13.0 
               
               
                   
                 Spleen Pool 
                 29.7 
                 28.1 
               
               
                   
                 Thymus Pool 
                 12.6 
                 10.9 
               
               
                   
                 CMS cancer (glio/astro) U87-MG 
                 0.9 
                 1.2 
               
               
                   
                 CMS cancer (glio/astro) U-118-MG 
                 1.7 
                 0.8 
               
               
                   
                 CMS cancer (neuro; met) SK-N-AS 
                 0.5 
                 0.0 
               
               
                   
                 CMS cancer (astro) SF-539 
                 0.0 
                 0.5 
               
               
                   
                 CMS cancer (astro) SNB-75 
                 1.3 
                 1.1 
               
               
                   
                 CMS cancer (glio) SNB-19 
                 0.2 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.1 
                 0.5 
               
               
                   
                 Brain (Amygdala) Pool 
                 2.6 
                 2.5 
               
               
                   
                 Brain (cerebellum) 
                 0.8 
                 1.5 
               
               
                   
                 Brain (fetal) 
                 2.3 
                 3.3 
               
               
                   
                 Brain (Hippocampus) Pool 
                 1.0 
                 2.3 
               
               
                   
                 Cerebral Cortex Pool 
                 1.2 
                 0.6 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 1.3 
                 0.0 
               
               
                   
                 Brain (Thalamus) Pool 
                 1.5 
                 1.5 
               
               
                   
                 Brain (whole) 
                 5.7 
                 4.7 
               
               
                   
                 Spinal Cord Pool 
                 1.1 
                 2.2 
               
               
                   
                 Adrenal Gland 
                 19.1 
                 29.1 
               
               
                   
                 Pituitary gland Pool 
                 0.5 
                 4.1 
               
               
                   
                 Salivary Gland 
                 3.8 
                 4.5 
               
               
                   
                 Thyroid (female) 
                 6.3 
                 5.4 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.0 
                 0.0 
               
               
                   
                 Pancreas Pool 
                 9.3 
                 9.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag274, Run 216607761    
               
               
                   
                   Column B - Rel. Exp. (%) Ag274, Run 220361695    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE QD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 23.3 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 13.2 
               
               
                   
                 CC Margin (ODO3866) 
                 10.0 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 6.0 
               
               
                   
                 CC Margin (ODO3868) 
                 6.0 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 3.1 
               
               
                   
                 CC Margin (ODO3920) 
                 10.9 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 10.2 
               
               
                   
                 CC Margin (ODO3921) 
                 25.5 
               
               
                   
                 CC from Partial Hepatectomy (ODO4309) Mets 
                 9.7 
               
               
                   
                 Liver Margin (ODO4309) 
                 48.3 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 14.4 
               
               
                   
                 Lung Margin (OD04451-02) 
                 17.8 
               
               
                   
                 Normal Prostate 6546-1 
                 11.0 
               
               
                   
                 Prostate Cancer (OD04410) 
                 9.7 
               
               
                   
                 Prostate Margin (OD04410) 
                 4.1 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 2.0 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 4.5 
               
               
                   
                 Normal Lung 061010 
                 66.0 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 100.0 
               
               
                   
                 Muscle Margin (ODO4286) 
                 72.2 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 35.4 
               
               
                   
                 Lung Margin (OD03126) 
                 68.3 
               
               
                   
                 Lung Cancer (OD04404) 
                 29.5 
               
               
                   
                 Lung Margin (OD04404) 
                 35.6 
               
               
                   
                 Lung Cancer (OD04565) 
                 12.4 
               
               
                   
                 Lung Margin (OD04565) 
                 36.1 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 18.6 
               
               
                   
                 Lung Margin (OD04237-02) 
                 22.4 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 4.2 
               
               
                   
                 Liver Margin (ODO4310) 
                 24.3 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 5.8 
               
               
                   
                 Lung Margin (OD04321) 
                 29.7 
               
               
                   
                 Normal Kidney 
                 12.2 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 16.5 
               
               
                   
                 Kidney Margin (OD04338) 
                 6.2 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 23.2 
               
               
                   
                 Kidney Margin (OD04339) 
                 4.6 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 11.8 
               
               
                   
                 Kidney Margin (OD04340) 
                 5.8 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 56.6 
               
               
                   
                 Kidney Margin (OD04348) 
                 22.8 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 24.0 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 2.6 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.9 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 2.6 
               
               
                   
                 Kidney Cancer 8120607 
                 5.7 
               
               
                   
                 Kidney Margin 8120608 
                 3.6 
               
               
                   
                 Kidney Cancer 8120613 
                 5.7 
               
               
                   
                 Kidney Margin 8120614 
                 3.5 
               
               
                   
                 Kidney Cancer 9010320 
                 61.1 
               
               
                   
                 Kidney Margin 9010321 
                 24.1 
               
               
                   
                 Normal Uterus 
                 5.4 
               
               
                   
                 Uterus Cancer 064011 
                 5.1 
               
               
                   
                 Normal Thyroid 
                 5.9 
               
               
                   
                 Thyroid Cancer 064010 
                 3.1 
               
               
                   
                 Thyroid Cancer A302152 
                 3.3 
               
               
                   
                 Thyroid Margin A302153 
                 13.5 
               
               
                   
                 Normal Breast 
                 13.2 
               
               
                   
                 Breast Cancer (OD04566) 
                 40.9 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 29.5 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 26.1 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 31.9 
               
               
                   
                 Breast Cancer 064006 
                 16.0 
               
               
                   
                 Breast Cancer 1024 
                 11.3 
               
               
                   
                 Breast Cancer 9100266 
                 3.7 
               
               
                   
                 Breast Margin 9100265 
                 4.7 
               
               
                   
                 Breast Cancer A209073 
                 5.7 
               
               
                   
                 Breast Margin A209073 
                 1.5 
               
               
                   
                 Normal Liver 
                 8.4 
               
               
                   
                 Liver Cancer 064003 
                 8.4 
               
               
                   
                 Liver Cancer 1025 
                 25.3 
               
               
                   
                 Liver Cancer 1026 
                 6.4 
               
               
                   
                 Liver Cancer 6004-T 
                 40.1 
               
               
                   
                 Liver Tissue 6004-N 
                 17.8 
               
               
                   
                 Liver Cancer 6005-T 
                 10.2 
               
               
                   
                 Liver Tissue 6005-N 
                 18.6 
               
               
                   
                 Normal Bladder 
                 60.7 
               
               
                   
                 Bladder Cancer 1023 
                 5.1 
               
               
                   
                 Bladder Cancer A302173 
                 18.6 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 28.5 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 48.6 
               
               
                   
                 Normal Ovary 
                 0.0 
               
               
                   
                 Ovarian Cancer 064008 
                 16.2 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 16.4 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 19.2 
               
               
                   
                 Normal Stomach 
                 6.4 
               
               
                   
                 Gastric Cancer 9060358 
                 2.0 
               
               
                   
                 Stomach Margin 9060359 
                 5.1 
               
               
                   
                 Gastric Cancer 9060395 
                 8.4 
               
               
                   
                 Stomach Margin 9060394 
                 10.2 
               
               
                   
                 Gastric Cancer 9060397 
                 17.4 
               
               
                   
                 Stomach Margin 9060396 
                 5.3 
               
               
                   
                 Gastric Cancer 064005 
                 14.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag274, Run 170849611    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE QE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Daoy- Medulloblastoma 
                 14.7 
               
               
                   
                 TE671- Medulloblastoma 
                 51.1 
               
               
                   
                 D283 Med- Medulloblastoma 
                 0.0 
               
               
                   
                 PFSK-1- Primitive Neuroectodermal 
                 0.0 
               
               
                   
                 XF-498- CNS 
                 0.0 
               
               
                   
                 SNB-78- Glioma 
                 10.5 
               
               
                   
                 SF-268- Glioblastoma 
                 0.0 
               
               
                   
                 T98G- Glioblastoma 
                 10.2 
               
               
                   
                 SK-N-SH- Neuroblastoma (metastasis) 
                 10.4 
               
               
                   
                 SF-295- Glioblastoma 
                 0.0 
               
               
                   
                 Cerebellum 
                 22.7 
               
               
                   
                 Cerebellum 
                 9.0 
               
               
                   
                 NCI-H292- Mucoepidermoid lung carcinoma 
                 0.0 
               
               
                   
                 DMS-114- Small cell lung cancer 
                 6.4 
               
               
                   
                 DMS-79- Small cell lung cancer 
                 32.8 
               
               
                   
                 NCI-H146- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H526- Small cell lung cancer 
                 11.3 
               
               
                   
                 NCI-N417- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H82- Small cell lung cancer 
                 5.0 
               
               
                   
                 NCI-H157- Squamous cell lung cancer (metastasis) 
                 0.0 
               
               
                   
                 NCI-H1155- Large cell lung cancer 
                 25.2 
               
               
                   
                 NCI-H1299- Large cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H727- Lung carcinoid 
                 0.0 
               
               
                   
                 NCI-UMC-11- Lung carcinoid 
                 11.5 
               
               
                   
                 LX-1- Small cell lung cancer 
                 49.7 
               
               
                   
                 Colo-205- Colon cancer 
                 0.0 
               
               
                   
                 KM12- Colon cancer 
                 22.7 
               
               
                   
                 KM20L2- Colon cancer 
                 0.0 
               
               
                   
                 NCI-H716- Colon cancer 
                 0.0 
               
               
                   
                 SW-48- Colon adenocarcinoma 
                 9.7 
               
               
                   
                 SW1116- Colon adenocarcinoma 
                 6.1 
               
               
                   
                 LS 174T- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-948- Colon adenocarcinoma 
                 7.5 
               
               
                   
                 SW-480- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-5- Gastric carcinoma 
                 0.0 
               
               
                   
                 KATO III- Gastric carcinoma 
                 66.0 
               
               
                   
                 NCI-SNU-16- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-1- Gastric carcinoma 
                 6.3 
               
               
                   
                 RF-1- Gastric adenocarcinoma 
                 5.5 
               
               
                   
                 RF-48- Gastric adenocarcinoma 
                 10.4 
               
               
                   
                 MKN-45- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-N87- Gastric carcinoma 
                 11.1 
               
               
                   
                 OVCAR-5- Ovarian carcinoma 
                 8.8 
               
               
                   
                 RL95-2- Uterine carcinoma 
                 0.0 
               
               
                   
                 HelaS3- Cervical adenocarcinoma 
                 3.4 
               
               
                   
                 Ca Ski- Cervical epidermoid carcinoma (metastasis) 
                 4.2 
               
               
                   
                 ES-2- Ovarian clear cell carcinoma 
                 9.7 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 5.6 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 100.0 
               
               
                   
                 MEG-01- Chronic myelogenous leukemia 
                 11.3 
               
               
                   
                 (megokaryoblast) 
               
               
                   
                 Raji- Burkitt&#39;s lymphoma 
                 5.4 
               
               
                   
                 Daudi- Burkitt&#39;s lymphoma 
                 5.1 
               
               
                   
                 U266- B-cell plasmacytoma 
                 7.4 
               
               
                   
                 CA46- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 0.0 
               
               
                   
                 JM1- pre-B-cell lymphoma 
                 0.0 
               
               
                   
                 Jurkat- T cell leukemia 
                 0.0 
               
               
                   
                 TF-1- Erythroleukemia 
                 0.0 
               
               
                   
                 HUT 78- T-cell lymphoma 
                 14.9 
               
               
                   
                 U937- Histiocytic lymphoma 
                 9.1 
               
               
                   
                 KU-812- Myelogenous leukemia 
                 39.5 
               
               
                   
                 769-P- Clear cell renal carcinoma 
                 6.0 
               
               
                   
                 Caki-2- Clear cell renal carcinoma 
                 9.7 
               
               
                   
                 SW 839- Clear cell renal carcinoma 
                 16.4 
               
               
                   
                 Rhabdoid kidney tumor 
                 6.7 
               
               
                   
                 Hs766T- Pancreatic carcinoma (LN metastasis) 
                 0.0 
               
               
                   
                 CAPAN-1- Pancreatic adenocarcinoma (liver metastasis) 
                 11.3 
               
               
                   
                 SU86.86- Pancreatic carcinoma (liver metastasis) 
                 0.0 
               
               
                   
                 BxPC-3- Pancreatic adenocarcinoma 
                 0.0 
               
               
                   
                 HPAC- Pancreatic adenocarcinoma 
                 0.0 
               
               
                   
                 MIA PaCa-2- Pancreatic carcinoma 
                 4.5 
               
               
                   
                 CFPAC-1- Pancreatic ductal adenocarcinoma 
                 7.4 
               
               
                   
                 PANC-1 - Pancreatic epithelioid ductal carcinoma 
                 58.6 
               
               
                   
                 T24- Bladder carcinma (transitional cell) 
                 0.0 
               
               
                   
                 5637- Bladder carcinoma 
                 11.1 
               
               
                   
                 HT-1197- Bladder carcinoma 
                 0.0 
               
               
                   
                 UM-UC-3- Bladder carcinma (transitional cell) 
                 10.8 
               
               
                   
                 A204- Rhabdomyosarcoma 
                 0.0 
               
               
                   
                 HT-1080- Fibrosarcoma 
                 0.0 
               
               
                   
                 MG-63- Osteosarcoma 
                 9.9 
               
               
                   
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 0.0 
               
               
                   
                 SJRH30- Rhabdomyosarcoma (met to bone marrow) 
                 3.8 
               
               
                   
                 A431- Epidermoid carcinoma 
                 0.0 
               
               
                   
                 WM266-4- Melanoma 
                 0.0 
               
               
                   
                 DU 145- Prostate carcinoma (brain metastasis) 
                 5.5 
               
               
                   
                 MDA-MB-468- Breast adenocarcinoma 
                 10.8 
               
               
                   
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-9- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 CAL 27- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag274, Run 170745273    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE QF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Secondary Th1 act 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 act 
                 0.4 
                 0.1 
               
               
                 Secondary Tr1 act 
                 0.2 
                 0.2 
               
               
                 Secondary Th1 rest 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 rest 
                 0.9 
                 0.0 
               
               
                 Secondary Tr1 rest 
                 0.3 
                 0.0 
               
               
                 Primary Th1 act 
                 0.4 
                 0.0 
               
               
                 Primary Th2 act 
                 0.3 
                 0.3 
               
               
                 Primary Tr1 act 
                 0.0 
                 0.0 
               
               
                 Primary Th1 rest 
                 0.4 
                 0.5 
               
               
                 Primary Th2 rest 
                 0.6 
                 0.1 
               
               
                 Primary Tr1 rest 
                 0.0 
                 0.3 
               
               
                 CD45RA CD4 lymphocyte act 
                 0.3 
                 0.2 
               
               
                 CD45RO CD4 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte rest 
                 0.7 
                 0.0 
               
               
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD4 lymphocyte none 
                 0.0 
                 0.8 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.3 
                 0.0 
               
               
                 LAK cells rest 
                 13.3 
                 12.6 
               
               
                 LAK cells IL-2 
                 0.5 
                 0.4 
               
               
                 LAK cells IL-2 + IL-12 
                 0.5 
                 1.6 
               
               
                 LAK cells IL-2 + IFN gamma 
                 0.8 
                 0.4 
               
               
                 LAK cells IL-2 + IL-18 
                 0.5 
                 0.4 
               
               
                 LAK cells PMA/ionomycin 
                 5.4 
                 6.9 
               
               
                 NK Cells IL-2 rest 
                 0.5 
                 0.1 
               
               
                 Two Way MLR 3 day 
                 44.4 
                 38.7 
               
               
                 Two Way MLR 5 day 
                 8.0 
                 6.9 
               
               
                 Two Way MLR 7 day 
                 0.4 
                 0.5 
               
               
                 PBMC rest 
                 1.4 
                 1.7 
               
               
                 PBMC PWM 
                 0.7 
                 0.5 
               
               
                 PBMC PHA-L 
                 2.6 
                 3.2 
               
               
                 Ramos (B cell) none 
                 0.0 
                 0.3 
               
               
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.7 
               
               
                 B lymphocytes PWM 
                 0.0 
                 0.0 
               
               
                 B lymphocytes CD40L and IL-4 
                 0.3 
                 0.6 
               
               
                 EOL-1 dbcAMP 
                 0.2 
                 0.4 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.3 
               
               
                 Dendritic cells none 
                 7.9 
                 6.4 
               
               
                 Dendritic cells LPS 
                 32.1 
                 31.6 
               
               
                 Dendritic cells anti-CD40 
                 3.8 
                 3.6 
               
               
                 Monocytes rest 
                 7.9 
                 8.4 
               
               
                 Monocytes LPS 
                 100.0 
                 100.0 
               
               
                 Macrophages rest 
                 3.6 
                 3.5 
               
               
                 Macrophages LPS 
                 95.3 
                 88.3 
               
               
                 HUVEC none 
                 0.2 
                 0.0 
               
               
                 HUVEC starved 
                 0.4 
                 0.3 
               
               
                 HUVEC IL-1beta 
                 0.5 
                 0.0 
               
               
                 HUVEC IFN gamma 
                 0.0 
                 0.1 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 0.3 
                 0.1 
               
               
                 HUVEC TNF alpha + IL4 
                 0.0 
                 0.2 
               
               
                 HUVEC IL-11 
                 0.2 
                 0.0 
               
               
                 Lung Microvascular EC none 
                 0.0 
                 0.3 
               
               
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
                 0.3 
               
               
                 Microvascular Dermal EC none 
                 0.0 
                 0.0 
               
               
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
                 0.2 
               
               
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
                 0.3 
               
               
                 Small airway epithelium none 
                 0.0 
                 0.0 
               
               
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
                 0.1 
               
               
                 Coronery artery SMC rest 
                 0.2 
                 0.0 
               
               
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Astrocytes rest 
                 0.0 
                 0.0 
               
               
                 Astrocytes TNFalpha + IL-1beta 
                 1.0 
                 0.3 
               
               
                 KU-812 (Basophil) rest 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 0.4 
                 0.1 
               
               
                 CCD1106 (Keratinocytes) none 
                 0.4 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.3 
                 0.9 
               
               
                 Liver cirrhosis 
                 2.3 
                 1.5 
               
               
                 Lupus kidney 
                 1.8 
                 0.8 
               
               
                 NCI-H292 none 
                 0.0 
                 0.4 
               
               
                 NCI-H292 IL-4 
                 0.3 
                 0.2 
               
               
                 NCI-H292 IL-9 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IL-13 
                 0.0 
                 0.2 
               
               
                 NCI-H292 IFN gamma 
                 0.0 
                 0.0 
               
               
                 HPAEC none 
                 0.3 
                 0.0 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast none 
                 0.3 
                 0.0 
               
               
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.3 
                 0.0 
               
               
                 Lung fibroblast IL-4 
                 0.4 
                 0.4 
               
               
                 Lung fibroblast IL-9 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-13 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IFN gamma 
                 0.0 
                 0.3 
               
               
                 Dermal fibroblast CCD1070 rest 
                 0.7 
                 0.2 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.4 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
                 0.1 
               
               
                 Dermal fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast IL-4 
                 0.4 
                 0.2 
               
               
                 IBD Colitis 2 
                 0.0 
                 0.2 
               
               
                 IBD Crohn&#39;s 
                 0.6 
                 0.7 
               
               
                 Colon 
                 4.1 
                 4.1 
               
               
                 Lung 
                 7.5 
                 8.0 
               
               
                 Thymus 
                 0.9 
                 0.1 
               
               
                 Kidney 
                 4.8 
                 3.0 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag274, Run 164533655    
               
               
                   Column B - Rel. Exp. (%) Ag274, Run 164534874    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE QG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 5D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 97457_Patient-02go_adipose 
                 100.0 
               
               
                   
                 97476_Patient-07sk_skeletal muscle 
                 18.9 
               
               
                   
                 97477_Patient-07ut_uterus 
                 15.2 
               
               
                   
                 97478_Patient-07pl_placenta 
                 28.9 
               
               
                   
                 97481_Patient-08sk_skeletal muscle 
                 17.1 
               
               
                   
                 97482_Patient-08ut_uterus 
                 7.4 
               
               
                   
                 97483_Patient-08pl_placenta 
                 25.9 
               
               
                   
                 97486_Patient-09sk_skeletal muscle 
                 22.1 
               
               
                   
                 97487_Patient-09ut_uterus 
                 13.7 
               
               
                   
                 97488_Patient-09pl_placenta 
                 6.7 
               
               
                   
                 97492_Patient-10ut_uterus 
                 23.0 
               
               
                   
                 97493_Patient-10pl_placenta 
                 16.5 
               
               
                   
                 97495_Patient-11go_adipose 
                 26.1 
               
               
                   
                 97496_Patient-11sk_skeletal muscle 
                 11.1 
               
               
                   
                 97497_Patient-11ut_uterus 
                 9.4 
               
               
                   
                 97498_Patient-11pl_placenta 
                 14.7 
               
               
                   
                 97500_Patient-12go_adipose 
                 25.0 
               
               
                   
                 97501_Patient-12sk_skeletal muscle 
                 7.0 
               
               
                   
                 97502_Patient-12ut_uterus 
                 37.9 
               
               
                   
                 97503_Patient-12pl_placenta 
                 9.5 
               
               
                   
                 94721_Donor 2 U - A_Mesenchymal Stem Cells 
                 6.5 
               
               
                   
                 94722_Donor 2 U - B_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94723_Donor 2 U - C_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94709_Donor 2 AM - A_adipose 
                 0.0 
               
               
                   
                 94710_Donor 2 AM - B_adipose 
                 10.3 
               
               
                   
                 94711_Donor 2 AM - C_adipose 
                 3.6 
               
               
                   
                 94712_Donor 2 AD - A_adipose 
                 0.0 
               
               
                   
                 94713_Donor 2 AD - B_adipose 
                 3.4 
               
               
                   
                 94714_Donor 2 AD - C_adipose 
                 0.0 
               
               
                   
                 94742_Donor 3 U - A_Mesenchymal Stem Cells 
                 6.3 
               
               
                   
                 94743_Donor 3 U - B_Mesenchymal Stem Cells 
                 7.4 
               
               
                   
                 94730_Donor 3 AM - A_adipose 
                 3.0 
               
               
                   
                 94731_Donor 3 AM - B_adipose 
                 10.2 
               
               
                   
                 94732_Donor 3 AM - C_adipose 
                 6.9 
               
               
                   
                 94733_Donor 3 AD - A_adipose 
                 1.6 
               
               
                   
                 94734_Donor 3 AD - B_adipose 
                 9.0 
               
               
                   
                 94735_Donor 3 AD - C_adipose 
                 6.6 
               
               
                   
                 77138_Liver_HepG2untreated 
                 7.4 
               
               
                   
                 73556_Heart_Cardiac stromal cells (primary) 
                 0.0 
               
               
                   
                 81735_Small Intestine 
                 22.1 
               
               
                   
                 72409_Kidney_Proximal Convoluted Tubule 
                 3.2 
               
               
                   
                 82685_Small intestine_Duodenum 
                 11.4 
               
               
                   
                 90650_Adrenal_Adrenocortical adenoma 
                 15.4 
               
               
                   
                 72410_Kidney_HRCE 
                 10.2 
               
               
                   
                 72411_Kidney_HRE 
                 2.9 
               
               
                   
                 73139_Uterus_Uterine smooth muscle cells 
                 3.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag274, Run 255179442    
               
            
           
         
       
     
      AI_comprehensive panel_v1.0 Summary: Ag274 Highest expression of this gene was detected in synovium of an osteooarthritis (OA) patient (CT=28.6). This gene showed a higher level of expression in the bone and synovium samples from OA patients relative to samples from rheumatoid arthritis patients and normal tissues. This gene encodes sialoadhesin (CD169), a lectin that binds to alpha-2,6-linked, sialic acid residues. It has been previously reported that expression of sialoadhesin is highly induced in synovial macrophages from patients with rheumatoid arthritis and in animal models of arthritis (Hartnell, A. Blood 97: 288-296; Dijkstra, C. D. Scand. J. Immunol. 26:5132). The expression profile in this panel confirmed expression of this gene in rheumatoid tissue and also demonstrated an upregulation in synovial tissue from OA patients. Modulation of this gene, expressed protein and/or use of antibodies or small molecule drug targeting the gene or gene product is useful in the treatment of osteoarthritis.  
      Low expression of this gene was also seen in samples from COPD lung, emphysema, atopic asthma, asthma, Crohn&#39;s disease (normal matched control and diseased), ulcerative colitis(normal matched control and diseased), and psoriasis (normal matched control and diseased). Therapeutic modulation of this gene or gene product is useful for the amelioration of symptoms/conditions associated with autoimmune and inflammatory disorders including psoriasis, asthma, inflammatory bowel disease, and rheumatoid arthritis.  
      General_screening 13  panel_v1.4 Summary: Ag274 Highest expression of this gene was detected in bladder (CTs=27-29). Expression of this gene was mainly associated with normal tissues in this panel. Among tissues with metabolic or endocrine function, this gene was expressed at moderate levels in pancreas, adipose, adrenal gland, thyroid, pituitary gland, skeletal muscle, heart, liver and the gastrointestinal tract. Therapeutic modulation of this gene or expressed protein is useful in the treatment of endocrine/metabolically related diseases, such as obesity and diabetes.  
      This gene was expressed at low levels in all regions of the central nervous system examined, including amygdala, hippocampus, substantia nigra, thalamus, cerebellum, cerebral cortex, and spinal cord. Therapeutic modulation of this gene product is useful in the treatment of central nervous system disorders such as Alzheimer&#39;s disease, Parkinson&#39;s disease, epilepsy, multiple sclerosis, schizophrenia and depression.  
      Significant expression of this gene was also seen in a colon cancer cell line. Modulation of this gene or encoded protein is useful in the treatment of colon cancer.  
      Panel 2D Summary: Ag274 Highest expression of this gene was detected in muscle cancer metastasized from lung (CT=29). Moderate expression of this gene was also seen in normal and cancer samples from colon, lung, kidney, liver, prostate, bladder, ovary and stomach. Therapeutic modulation of this gene or expressed protein is useful in the treatment of these cancers.  
      Panel 3D Summary: Ag274 Expression of this gene was highest in the Ramos cell line stimulated with PMA and ionomycin for 16 hrs, followed by lower expression in cell lines derived from gastric carcinoma and pancreatic ductal carcinoma, and lower still in small cell lung carcinoma, medulloblastoma and myelogenous leukemia.  
      Panel 4D Summary: Ag274 Highest expression of this gene was detected in LPS treated monocytes (CTs=27). The expression of this gene was limited to LPS activated monocytes, macrophages and related cell types or derived from monocytes (dendritic cells). The putative sialoadhesin encoded by this gene directs monocyte extravasation into tissues, and acts as a cell:cell interaction molecule. Modulation of this gene, expressed protein and/or use of antibodies is useful for blocking monocyte extravasation and reducing or inhibiting inflammation associated with asthma, psoriasis, emphysema, arthritis, and other inflammatory diseases.  
      Panel 5D Summary: Ag274 Highest expression of this gene was detected in adipose of a diabetic patient (CT=31). Significant expression of this gene was also seen in skeletal muscle and placenta from obese and/or diabetic patients. Therapeutic modulation of this gene or expressed protein is useful in the treatment of metabolic/endocrine diseases such as obesity and diabetes.  
      R. CG51992-05: CTCL Tumor Antigens E57-1  
      Expression of gene CG51992-05 was assessed using the primer-probe sets Ag1920, Ag2775, Ag2776, and Ag5232, described in Tables RA, RB, RC, and RD. Results of the RTQ-PCR runs are shown in Tables RE, RF, RG, and RH.  
               TABLE RA                          Probe Name Ag1920                                 Primers   Sequences   Length   Start Position   SEQ ID No                                             Forward   5′-gctcctggagaatggaaatc-3′   20   902   1324                   Probe   TET-5′-tccctctgaagatcctggcaactttt-3′-TAMRA   26   876   1325               Reverse   5′-caagctactgcaactcaaatcc-3′   22   839   1326                  
 
     
       
         
           
               
             
               
                 TABLE RB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag2775 
               
            
           
           
               
               
               
               
               
            
               
                 Primers 
                 Sequences 
                 Length 
                 Start Position 
                 SEQ ID No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-caggatcttcagagggagattt-3′ 
                 22 
                 885 
                 1327 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ctccaggagcagatctctcatctgca-3′-TAMRA 
                 26 
                 912 
                 1328 
               
               
                   
               
               
                 Reverse 
                 5′-atgttgggagtgaatcacaaac-3′ 
                 22 
                 938 
                 1329 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE RC 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag2776 
               
            
           
           
               
               
               
               
               
            
               
                 Primers 
                 Sequences 
                 Length 
                 Start Position 
                 SEQ ID No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-aaatgtcatcttcttgcaaagc-3′ 
                 22 
                 1333 
                 1330 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-tccatttaaataatggcattttgcca-3′-TAMRA 
                 26 
                 1289 
                 1331 
               
               
                   
               
               
                 Reverse 
                 5′-cagcccaagtttcatgttaaaa-3′ 
                 22 
                 1267 
                 1332 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE RD 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag5232 
               
            
           
           
               
               
               
               
               
            
               
                 Primers 
                 Sequences 
                 Length 
                 Start Position 
                 SEQ ID No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-ctagatgcaaagctgcaagc-3′ 
                 20 
                 531 
                 1333 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-aagcaggagcagcagctctgagaaac-3′-TAMRA 
                 26 
                 559 
                 1334 
               
               
                   
               
               
                 Reverse 
                 5′-cttcttcagattgcgtttgg-3′ 
                 20 
                 611 
                 1335 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE RE 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.5  
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 3.7 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 1.6 
               
               
                   
                 Melanoma* M14 
                 0.2 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.0 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 3.1 
               
               
                   
                 Testis Pool 
                 7.9 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 3.9 
               
               
                   
                 Prostate Pool 
                 4.1 
               
               
                   
                 Placenta 
                 1.4 
               
               
                   
                 Uterus Pool 
                 1.3 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 1.5 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 28.9 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.3 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 2.9 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.1 
               
               
                   
                 Ovary 
                 9.4 
               
               
                   
                 Breast ca. MCF-7 
                 0.1 
               
               
                   
                 Breast ca. MDA-MB-231 
                 11.4 
               
               
                   
                 Breast ca. BT 549 
                 71.7 
               
               
                   
                 Breast ca. T47D 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Breast Pool 
                 4.0 
               
               
                   
                 Trachea 
                 3.2 
               
               
                   
                 Lung 
                 5.1 
               
               
                   
                 Fetal Lung 
                 100.0 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 2.2 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.0 
               
               
                   
                 Lung ca. A549 
                 11.3 
               
               
                   
                 Lung ca. NCI-H526 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 1.5 
               
               
                   
                 Lung ca. NCI-H460 
                 94.0 
               
               
                   
                 Lung ca. HOP-62 
                 1.2 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 20.9 
               
               
                   
                 Liver ca. HepG2 
                 19.8 
               
               
                   
                 Kidney Pool 
                 6.0 
               
               
                   
                 Fetal Kidney 
                 12.9 
               
               
                   
                 Renal ca. 786-0 
                 3.0 
               
               
                   
                 Renal ca. A498 
                 1.6 
               
               
                   
                 Renal ca. ACHN 
                 1.0 
               
               
                   
                 Renal ca. UO-31 
                 8.4 
               
               
                   
                 Renal ca. TK-10 
                 7.6 
               
               
                   
                 Bladder 
                 38.4 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 4.4 
               
               
                   
                 Gastric ca. KATO III 
                 53.2 
               
               
                   
                 Colon ca. SW-948 
                 17.9 
               
               
                   
                 Colon ca. SW480 
                 1.2 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.1 
               
               
                   
                 Colon ca. HT29 
                 1.3 
               
               
                   
                 Colon ca. HCT-116 
                 7.3 
               
               
                   
                 Colon ca. CaCo-2 
                 7.5 
               
               
                   
                 Colon cancer tissue 
                 7.0 
               
               
                   
                 Colon ca. SW1116 
                 0.8 
               
               
                   
                 Colon ca. Colo-205 
                 0.6 
               
               
                   
                 Colon ca. SW-48 
                 1.0 
               
               
                   
                 Colon Pool 
                 1.8 
               
               
                   
                 Small Intestine Pool 
                 2.5 
               
               
                   
                 Stomach Pool 
                 4.1 
               
               
                   
                 Bone Marrow Pool 
                 3.4 
               
               
                   
                 Fetal Heart 
                 1.7 
               
               
                   
                 Heart Pool 
                 7.2 
               
               
                   
                 Lymph Node Pool 
                 6.2 
               
               
                   
                 Fetal Skeletal Muscle 
                 0.0 
               
               
                   
                 Skeletal Muscle Pool 
                 11.8 
               
               
                   
                 Spleen Pool 
                 15.0 
               
               
                   
                 Thymus Pool 
                 2.2 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 0.0 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.1 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 0.3 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.0 
               
               
                   
                 Brain (Amygdala) Pool 
                 1.8 
               
               
                   
                 Brain (cerebellum) 
                 1.0 
               
               
                   
                 Brain (fetal) 
                 0.4 
               
               
                   
                 Brain (Hippocampus) Pool 
                 0.3 
               
               
                   
                 Cerebral Cortex Pool 
                 3.1 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 0.8 
               
               
                   
                 Brain (Thalamus) Pool 
                 2.3 
               
               
                   
                 Brain (whole) 
                 0.1 
               
               
                   
                 Spinal Cord Pool 
                 2.1 
               
               
                   
                 Adrenal Gland 
                 1.5 
               
               
                   
                 Pituitary gland Pool 
                 3.2 
               
               
                   
                 Salivary Gland 
                 0.4 
               
               
                   
                 Thyroid (female) 
                 0.2 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 1.6 
               
               
                   
                 Pancreas Pool 
                 9.9 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag5232, Run 229385253    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE RF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 1.9 
                 3.8 
               
               
                   
                 Pancreas 
                 1.2 
                 0.8 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 1.4 
                 0.9 
               
               
                   
                 Adrenal gland 
                 4.0 
                 10.7 
               
               
                   
                 Thyroid 
                 3.3 
                 2.6 
               
               
                   
                 Salivary gland 
                 2.3 
                 2.2 
               
               
                   
                 Pituitary gland 
                 14.7 
                 11.8 
               
               
                   
                 Brain (fetal) 
                 0.2 
                 0.0 
               
               
                   
                 Brain (whole) 
                 10.4 
                 9.7 
               
               
                   
                 Brain (amygdala) 
                 5.5 
                 3.7 
               
               
                   
                 Brain (cerebellum) 
                 0.2 
                 0.7 
               
               
                   
                 Brain (hippocampus) 
                 19.5 
                 30.1 
               
               
                   
                 Brain (substantia nigra) 
                 2.0 
                 1.8 
               
               
                   
                 Brain (thalamus) 
                 8.8 
                 13.4 
               
               
                   
                 Cerebral Cortex 
                 20.0 
                 14.3 
               
               
                   
                 Spinal cord 
                 3.5 
                 3.7 
               
               
                   
                 glio/astro U87-MG 
                 0.5 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SW1783 
                 0.2 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.6 
                 0.0 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 10.3 
                 4.8 
               
               
                   
                 glioma SNB-19 
                 0.0 
                 0.0 
               
               
                   
                 glioma U251 
                 0.3 
                 0.0 
               
               
                   
                 glioma SF-295 
                 0.2 
                 0.0 
               
               
                   
                 Heart (fetal) 
                 1.7 
                 1.0 
               
               
                   
                 Heart 
                 8.9 
                 11.2 
               
               
                   
                 Skeletal muscle (fetal) 
                 2.7 
                 0.7 
               
               
                   
                 Skeletal muscle 
                 1.7 
                 2.0 
               
               
                   
                 Bone marrow 
                 2.7 
                 3.9 
               
               
                   
                 Thymus 
                 0.0 
                 0.0 
               
               
                   
                 Spleen 
                 16.3 
                 9.2 
               
               
                   
                 Lymph node 
                 4.3 
                 4.1 
               
               
                   
                 Colorectal 
                 42.0 
                 12.5 
               
               
                   
                 Stomach 
                 29.9 
                 7.1 
               
               
                   
                 Small intestine 
                 38.4 
                 40.6 
               
               
                   
                 Colon ca. SW480 
                 1.2 
                 0.0 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 4.7 
                 0.5 
               
               
                   
                 Colon ca. HCT-116 
                 5.3 
                 3.5 
               
               
                   
                 Colon ca. CaCo-2 
                 10.7 
                 4.7 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 6.3 
                 3.5 
               
               
                   
                 Colon ca. HCC-2998 
                 5.6 
                 4.7 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 7.7 
                 3.3 
               
               
                   
                 Bladder 
                 22.1 
                 21.5 
               
               
                   
                 Trachea 
                 15.3 
                 4.4 
               
               
                   
                 Kidney 
                 2.2 
                 4.0 
               
               
                   
                 Kidney (fetal) 
                 8.4 
                 14.9 
               
               
                   
                 Renal ca. 786-0 
                 7.6 
                 2.5 
               
               
                   
                 Renal ca. A498 
                 10.7 
                 4.3 
               
               
                   
                 Renal ca. RXF 393 
                 2.1 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.9 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 5.3 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 4.5 
                 1.8 
               
               
                   
                 Liver 
                 5.3 
                 9.5 
               
               
                   
                 Liver (fetal) 
                 21.8 
                 39.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 19.5 
                 9.7 
               
               
                   
                 Lung 
                 38.7 
                 53.6 
               
               
                   
                 Lung (fetal) 
                 100.0 
                 100.0 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 2.8 
                 2.3 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 75.3 
                 38.4 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 12.2 
                 10.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 2.3 
                 2.3 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 2.2 
                 0.6 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 9.3 
                 12.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
                 0.0 
               
               
                   
                 Mammary gland 
                 3.8 
                 1.9 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 15.5 
                 10.4 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 10.2 
                 6.2 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
                 0.0 
               
               
                   
                 Ovary 
                 13.1 
                 7.7 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 1.7 
                 0.6 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 7.3 
                 1.2 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 2.4 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 9.7 
                 4.0 
               
               
                   
                 Uterus 
                 9.6 
                 6.3 
               
               
                   
                 Placenta 
                 34.2 
                 37.6 
               
               
                   
                 Prostate 
                 12.9 
                 12.6 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 1.2 
                 0.8 
               
               
                   
                 Testis 
                 39.5 
                 13.0 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.3 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma M14 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
                 0.0 
               
               
                   
                 Adipose 
                 3.9 
                 3.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2775, Run 153780557    
               
               
                   
                   Column B - Rel. Exp. (%) Ag2776, Run 153792445    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE RG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Normal Colon 
                 94.0 
                 62.4 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 5.0 
                 3.1 
               
               
                   
                 CC Margin (ODO3866) 
                 21.6 
                 18.8 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 4.5 
                 2.0 
               
               
                   
                 CC Margin (ODO3868) 
                 1.4 
                 1.2 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 8.2 
                 4.9 
               
               
                   
                 CC Margin (ODO3920) 
                 34.4 
                 28.5 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 20.0 
                 17.7 
               
               
                   
                 CC Margin (ODO3921) 
                 12.2 
                 10.2 
               
               
                   
                 CC from Partial Hepatectomy 
                 11.3 
                 4.8 
               
               
                   
                 (ODO4309) Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 10.2 
                 5.6 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 4.7 
                 0.8 
               
               
                   
                 Lung Margin (OD04451-02) 
                 14.2 
                 6.4 
               
               
                   
                 Normal Prostate 6546-1 
                 7.6 
                 5.4 
               
               
                   
                 Prostate Cancer (OD04410) 
                 2.9 
                 2.7 
               
               
                   
                 Prostate Margin (OD04410) 
                 7.0 
                 3.4 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 7.0 
                 4.0 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 8.1 
                 6.5 
               
               
                   
                 Normal Lung 061010 
                 44.1 
                 45.4 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 4.3 
                 5.2 
               
               
                   
                 Muscle Margin (ODO4286) 
                 1.5 
                 0.6 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 12.3 
                 5.6 
               
               
                   
                 Lung Margin (OD03126) 
                 33.7 
                 13.8 
               
               
                   
                 Lung Cancer (OD04404) 
                 4.1 
                 0.9 
               
               
                   
                 Lung Margin (OD04404) 
                 11.5 
                 3.0 
               
               
                   
                 Lung Cancer (OD04565) 
                 2.9 
                 0.6 
               
               
                   
                 Lung Margin (OD04565) 
                 19.6 
                 3.7 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 6.8 
                 3.4 
               
               
                   
                 Lung Margin (OD04237-02) 
                 22.4 
                 9.3 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 11.3 
                 5.8 
               
               
                   
                 Liver Margin (ODO4310) 
                 10.4 
                 6.0 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.3 
                 0.0 
               
               
                   
                 Lung Margin (OD04321) 
                 27.9 
                 31.6 
               
               
                   
                 Normal Kidney 
                 7.0 
                 3.6 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 1.7 
                 0.4 
               
               
                   
                 Kidney Margin (OD04338) 
                 6.0 
                 0.5 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 4.7 
                 0.4 
               
               
                   
                 Kidney Margin (OD04339) 
                 11.4 
                 1.8 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 0.9 
                 0.0 
               
               
                   
                 Kidney Margin (OD04340) 
                 10.6 
                 3.5 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.6 
                 0.2 
               
               
                   
                 Kidney Margin (OD04348) 
                 6.4 
                 1.6 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 0.9 
                 0.2 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 4.1 
                 1.5 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 5.6 
                 1.6 
               
               
                   
                 Kidney Cancer 8120607 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin 8120608 
                 0.1 
                 0.0 
               
               
                   
                 Kidney Cancer 8120613 
                 1.3 
                 0.2 
               
               
                   
                 Kidney Margin 8120614 
                 0.3 
                 0.0 
               
               
                   
                 Kidney Cancer 9010320 
                 1.5 
                 0.0 
               
               
                   
                 Kidney Margin 9010321 
                 1.0 
                 0.0 
               
               
                   
                 Normal Uterus 
                 1.8 
                 0.8 
               
               
                   
                 Uterus Cancer 064011 
                 4.6 
                 1.4 
               
               
                   
                 Normal Thyroid 
                 3.6 
                 1.6 
               
               
                   
                 Thyroid Cancer 064010 
                 1.7 
                 1.1 
               
               
                   
                 Thyroid Cancer A302152 
                 0.1 
                 0.2 
               
               
                   
                 Thyroid Margin A302153 
                 2.9 
                 1.1 
               
               
                   
                 Normal Breast 
                 2.8 
                 1.2 
               
               
                   
                 Breast Cancer (OD04566) 
                 2.9 
                 0.2 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 1.5 
                 0.5 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 4.8 
                 1.5 
               
               
                   
                 Breast Cancer Metastasis 
                 0.7 
                 0.4 
               
               
                   
                 (OD04655-05) 
               
               
                   
                 Breast Cancer 064006 
                 2.9 
                 1.4 
               
               
                   
                 Breast Cancer 1024 
                 0.4 
                 0.0 
               
               
                   
                 Breast Cancer 9100266 
                 0.4 
                 0.0 
               
               
                   
                 Breast Margin 9100265 
                 0.1 
                 0.2 
               
               
                   
                 Breast Cancer A209073 
                 1.4 
                 0.8 
               
               
                   
                 Breast Margin A209073 
                 1.5 
                 1.0 
               
               
                   
                 Normal Liver 
                 7.7 
                 1.7 
               
               
                   
                 Liver Cancer 064003 
                 8.7 
                 6.6 
               
               
                   
                 Liver Cancer 1025 
                 3.3 
                 0.8 
               
               
                   
                 Liver Cancer 1026 
                 0.8 
                 0.3 
               
               
                   
                 Liver Cancer 6004-T 
                 3.8 
                 0.7 
               
               
                   
                 Liver Tissue 6004-N 
                 4.7 
                 0.7 
               
               
                   
                 Liver Cancer 6005-T 
                 0.8 
                 0.2 
               
               
                   
                 Liver Tissue 6005-N 
                 0.4 
                 0.3 
               
               
                   
                 Normal Bladder 
                 33.7 
                 27.2 
               
               
                   
                 Bladder Cancer 1023 
                 5.1 
                 3.1 
               
               
                   
                 Bladder Cancer A302173 
                 1.3 
                 0.6 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 12.2 
                 9.6 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 0.6 
                 0.5 
               
               
                   
                 Normal Ovary 
                 2.0 
                 1.5 
               
               
                   
                 Ovarian Cancer 064008 
                 5.8 
                 4.0 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 0.1 
                 0.0 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 0.2 
                 0.1 
               
               
                   
                 Normal Stomach 
                 25.9 
                 12.3 
               
               
                   
                 Gastric Cancer 9060358 
                 1.5 
                 0.9 
               
               
                   
                 Stomach Margin 9060359 
                 4.2 
                 6.3 
               
               
                   
                 Gastric Cancer 9060395 
                 14.6 
                 9.8 
               
               
                   
                 Stomach Margin 9060394 
                 8.7 
                 12.4 
               
               
                   
                 Gastric Cancer 9060397 
                 10.9 
                 13.5 
               
               
                   
                 Stomach Margin 9060396 
                 4.8 
                 3.3 
               
               
                   
                 Gastric Cancer 064005 
                 100.0 
                 100.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2775, Run 153780568    
               
               
                   
                   Column B - Rel. Exp. (%) Ag2776, Run 153792446    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE RH 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Secondary Th1 act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 act 
                 0.4 
                 0.0 
                 0.6 
               
               
                 Secondary Tr1 act 
                 0.0 
                 0.0 
                 0.5 
               
               
                 Secondary Th1 rest 
                 0.2 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 rest 
                 0.0 
                 0.0 
                 0.2 
               
               
                 Secondary Tr1 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th1 act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th2 act 
                 0.0 
                 0.0 
                 0.2 
               
               
                 Primary Tr1 act 
                 0.2 
                 0.2 
                 0.0 
               
               
                 Primary Th1 rest 
                 0.0 
                 0.1 
                 0.0 
               
               
                 Primary Th2 rest 
                 0.0 
                 0.0 
                 0.2 
               
               
                 Primary Tr1 rest 
                 0.1 
                 0.0 
                 0.0 
               
               
                 CD45RA CD4 lymphocyte act 
                 0.3 
                 0.8 
                 0.3 
               
               
                 CD45RO CD4 lymphocyte act 
                 0.0 
                 0.0 
                 0.3 
               
               
                 CD8 lymphocyte act 
                 0.3 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
                 0.2 
               
               
                 CD4 lymphocyte none 
                 0.0 
                 0.2 
                 0.0 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
                 0.0 
                 0.3 
               
               
                 LAK cells rest 
                 0.0 
                 0.1 
                 0.8 
               
               
                 LAK cells IL-2 
                 0.7 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-12 
                 0.2 
                 0.4 
                 0.0 
               
               
                 LAK cells IL-2 + IFN gamma 
                 0.9 
                 0.4 
                 0.9 
               
               
                 LAK cells IL-2 + IL-18 
                 1.0 
                 0.0 
                 0.6 
               
               
                 LAK cells PMA/ionomycin 
                 0.6 
                 0.0 
                 0.0 
               
               
                 NK Cells IL-2 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 3 day 
                 0.2 
                 0.4 
                 0.4 
               
               
                 Two Way MLR 5 day 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 7 day 
                 0.0 
                 0.0 
                 0.0 
               
               
                 PBMC rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 PBMC PWM 
                 0.6 
                 0.0 
                 0.7 
               
               
                 PBMC PHA-L 
                 0.0 
                 0.4 
                 0.0 
               
               
                 Ramos (B cell) none 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
                 0.0 
               
               
                 B lymphocytes PWM 
                 0.6 
                 0.4 
                 0.6 
               
               
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP 
                 0.2 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells none 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells LPS 
                 0.4 
                 0.0 
                 0.0 
               
               
                 Dendritic cells anti-CD40 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Monocytes rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Monocytes LPS 
                 0.5 
                 0.0 
                 0.0 
               
               
                 Macrophages rest I 
                 0.0 
                 0.4 
                 0.0 
               
               
                 Macrophages LPS 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC none 
                 10.8 
                 8.4 
                 5.8 
               
               
                 HUVEC starved 
                 20.7 
                 12.9 
                 7.1 
               
               
                 HUVEC IL-1 beta 
                 5.6 
                 5.6 
                 2.3 
               
               
                 HUVEC IFN gamma 
                 22.1 
                 19.9 
                 8.2 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 8.4 
                 8.8 
                 9.2 
               
               
                 HUVEC TNF alpha + IL4 
                 5.3 
                 5.4 
                 3.4 
               
               
                 HUVEC IL-11 
                 2.8 
                 3.1 
                 2.1 
               
               
                 Lung Microvascular EC none 
                 25.5 
                 11.7 
                 15.1 
               
               
                 Lung Microvascular EC 
                 12.4 
                 10.2 
                 9.3 
               
               
                 TNFalpha + IL-1beta 
               
               
                 Microvascular Dermal EC none 
                 23.3 
                 16.5 
                 28.5 
               
               
                 Microsvasular Dermal EC 
                 12.4 
                 9.4 
                 9.9 
               
               
                 TNFalpha + IL-1beta 
               
               
                 Bronchial epithelium TNFalpha + 
                 18.7 
                 2.9 
                 2.3 
               
               
                 IL1beta 
               
               
                 Small airway epithelium none 
                 9.5 
                 6.2 
                 8.1 
               
               
                 Small airway epithelium 
                 82.4 
                 67.4 
                 31.2 
               
               
                 TNFalpha + IL-1 beta 
               
               
                 Coronery artery SMC rest 
                 20.0 
                 10.7 
                 4.6 
               
               
                 Coronery artery SMC TNFalpha + 
                 10.7 
                 10.6 
                 2.6 
               
               
                 IL-1beta 
               
               
                 Astrocytes rest 
                 0.4 
                 0.7 
                 0.9 
               
               
                 Astrocytes TNFalpha + IL-1beta 
                 2.3 
                 1.8 
                 1.4 
               
               
                 KU-812 (Basophil) rest 
                 0.9 
                 0.3 
                 0.4 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 4.5 
                 4.5 
                 2.9 
               
               
                 CCD1106 (Keratinocytes) none 
                 9.0 
                 6.6 
                 7.6 
               
               
                 CCD1106 (Keratinocytes) 
                 4.6 
                 0.8 
                 2.6 
               
               
                 TNFalpha + IL-1beta 
               
               
                 Liver cirrhosis 
                 9.0 
                 12.1 
                 5.7 
               
               
                 Lupus kidney 
                 1.4 
                 1.6 
                 0.9 
               
               
                 NCI-H292 none 
                 36.3 
                 29.5 
                 27.9 
               
               
                 NCI-H292 IL-4 
                 76.8 
                 77.4 
                 60.3 
               
               
                 NCI-H292 IL-9 
                 72.7 
                 67.4 
                 39.2 
               
               
                 NCI-H292 IL-13 
                 35.1 
                 34.2 
                 12.9 
               
               
                 NCI-H292 IFN gamma 
                 100.0 
                 100.0 
                 59.9 
               
               
                 HPAEC none 
                 5.3 
                 3.7 
                 2.7 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 4.8 
                 4.2 
                 4.3 
               
               
                 Lung fibroblast none 
                 13.2 
                 8.7 
                 4.9 
               
               
                 Lung fibroblast TNF alpha + IL-1 
                 30.8 
                 28.9 
                 20.9 
               
               
                 beta 
               
               
                 Lung fibroblast IL-4 
                 22.4 
                 18.7 
                 13.8 
               
               
                 Lung fibroblast IL-9 
                 12.4 
                 9.2 
                 11.6 
               
               
                 Lung fibroblast IL-13 
                 11.4 
                 8.0 
                 13.9 
               
               
                 Lung fibroblast IFN gamma 
                 88.9 
                 78.5 
                 97.3 
               
               
                 Dermal fibroblast CCD1070 rest 
                 2.3 
                 3.3 
                 2.6 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 3.6 
                 3.3 
                 3.2 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.8 
                 0.8 
                 0.5 
               
               
                 Dermal fibroblast IFN gamma 
                 0.2 
                 0.2 
                 0.0 
               
               
                 Dermal fibroblast IL-4 
                 0.7 
                 0.0 
                 0.0 
               
               
                 IBD Colitis 2 
                 0.2 
                 1.4 
                 0.0 
               
               
                 IBD Crohn&#39;s 
                 9.8 
                 17.6 
                 10.5 
               
               
                 Colon 
                 83.5 
                 72.2 
                 100.0 
               
               
                 Lung 
                 40.3 
                 27.4 
                 44.4 
               
               
                 Thymus 
                 21.6 
                 18.4 
                 23.8 
               
               
                 Kidney 
                 2.2 
                 2.1 
                 1.7 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag1920, Run 158535362    
               
               
                   Column B - Rel. Exp. (%) Ag2775, Run 153780789    
               
               
                   Column C - Rel. Exp. (%) Ag2776, Run 153792447    
               
            
           
         
       
     
      General_screening 13  panel_v1.5 Summary: Ag5232 Highest expression was seen in fetal lung (CT=29.3), with moderate levels of expression also seen in breast, ovarian, lung and gastric cancer cell lines.  
      Panel 1.3D Summary: Ag2775/Ag2776 Expression of this gene was highest in fetal lung. This gene was expressed at higher levels in normal tissues than in the cancer cell lines. Significant expression of this gene was seen throughout the brain as well as in liver, small intestine, placenta, and bladder.  
      Panel 2D Summary: Ag2775/Ag2776 Expression of this gene was highest in a gastric cancer sample. Expression of this gene was lower in lung and kidney tumors when compared to the matched normal adjacent tissue. These results were consistent with what is observed in Panel 1.3D. Targeting of this gene or gene product through the use of protein, antibody, or small molecule therapeutics is beneficial in the treatment of lung and kidney cancer.  
      Panel 4D Summary: Ag1920/Ag2775/Ag2776 Expression of this gene was highest in lung cells, including in lung fibroblasts, small airway epithelium and the NCI-H292 cell line, a human airway epithelial cell line that produces mucins. These results were consistent with what is observed in Panels 1.3D and 2D. The expression of this gene in cells derived from or within the lung shows that this gene is involved in normal conditions as well as pathological and inflammatory lung disorders that include chronic obstructive pulmonary disease, asthma, allergy and emphysema.  
      Moderate expression of this gene was also seen in colon and thymus.  
      S. CG52171-04: Hematopoietic PBX-interacting Protein  
      Expression of gene CG52171-04 was assessed using the primer-probe set Ag2779, described in Table SA. Results of the RTQ-PCR runs are shown in Tables SB, SC, SD, SE and SF.  
               TABLE SA                          Probe Name Ag2779                                 Primers   Sequences   Length   Start Position   SEQ ID No                                             Forward   5′-caacagacaggtgatgatgatg-3′   22   2097   1336                   Probe   TET-5′-tgactttgaggacttcatcttcagcca-3′-TAMRA   27   2126   1337               Reverse   5′-cagtgctttgtctccaaagaag-3′   22   2153   1338                  
 
     
       
         
           
               
             
               
                 TABLE SB 
               
             
            
               
                   
               
               
                   
               
               
                 AI_comprehensive panel_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 110967 COPD-F 
                 32.8 
               
               
                   
                 110980 COPD-F 
                 28.7 
               
               
                   
                 110968 COPD-M 
                 45.4 
               
               
                   
                 110977 COPD-M 
                 70.7 
               
               
                   
                 110989 Emphysema-F 
                 73.7 
               
               
                   
                 110992 Emphysema-F 
                 25.7 
               
               
                   
                 110993 Emphysema-F 
                 27.2 
               
               
                   
                 110994 Emphysema-F 
                 14.9 
               
               
                   
                 110995 Emphysema-F 
                 43.5 
               
               
                   
                 110996 Emphysema-F 
                 10.7 
               
               
                   
                 110997 Asthma-M 
                 8.7 
               
               
                   
                 111001 Asthma-F 
                 25.0 
               
               
                   
                 111002 Asthma-F 
                 33.9 
               
               
                   
                 111003 Atopic Asthma-F 
                 27.2 
               
               
                   
                 111004 Atopic Asthma-F 
                 43.8 
               
               
                   
                 111005 Atopic Asthma-F 
                 27.4 
               
               
                   
                 111006 Atopic Asthma-F 
                 7.3 
               
               
                   
                 111417 Allergy-M 
                 1.2 
               
               
                   
                 112347 Allergy-M 
                 2.9 
               
               
                   
                 112349 Normal Lung-F 
                 2.4 
               
               
                   
                 112357 Normal Lung-F 
                 100.0 
               
               
                   
                 112354 Normal Lung-M 
                 32.1 
               
               
                   
                 112374 Crohns-F 
                 24.1 
               
               
                   
                 112389 Match Control Crohns-F 
                 17.7 
               
               
                   
                 112375 Crohns-F 
                 25.9 
               
               
                   
                 112732 Match Control Crohns-F 
                 39.5 
               
               
                   
                 112725 Crohns-M 
                 3.0 
               
               
                   
                 112387 Match Control Crohns-M 
                 31.6 
               
               
                   
                 112378 Crohns-M 
                 2.3 
               
               
                   
                 112390 Match Control Crohns-M 
                 45.7 
               
               
                   
                 112726 Crohns-M 
                 45.4 
               
               
                   
                 112731 Match Control Crohns-M 
                 29.5 
               
               
                   
                 112380 Ulcer Col-F 
                 27.4 
               
               
                   
                 112734 Match Control Ulcer Col-F 
                 57.8 
               
               
                   
                 112384 Ulcer Col-F 
                 35.4 
               
               
                   
                 112737 Match Control Ulcer Col-F 
                 11.6 
               
               
                   
                 112386 Ulcer Col-F 
                 19.3 
               
               
                   
                 112738 Match Control Ulcer Col-F 
                 13.3 
               
               
                   
                 112381 Ulcer Col-M 
                 3.0 
               
               
                   
                 112735 Match Control Ulcer Col-M 
                 11.0 
               
               
                   
                 112382 Ulcer Col-M 
                 14.8 
               
               
                   
                 112394 Match Control Ulcer Col-M 
                 8.5 
               
               
                   
                 112383 Ulcer Col-M 
                 26.1 
               
               
                   
                 112736 Match Control Ulcer Col-M 
                 9.9 
               
               
                   
                 112423 Psoriasis-F 
                 18.3 
               
               
                   
                 112427 Match Control Psoriasis-F 
                 71.7 
               
               
                   
                 112418 Psoriasis-M 
                 28.1 
               
               
                   
                 112723 Match Control Psoriasis-M 
                 35.6 
               
               
                   
                 112419 Psoriasis-M 
                 45.1 
               
               
                   
                 112424 Match Control Psoriasis-M 
                 15.7 
               
               
                   
                 112420 Psoriasis-M 
                 62.0 
               
               
                   
                 112425 Match Control Psoriasis-M 
                 40.1 
               
               
                   
                 104689 (MF) OA Bone-Backus 
                 31.2 
               
               
                   
                 104690 (MF) Adj “Normal” Bone-Backus 
                 21.0 
               
               
                   
                 104691 (MF) OA Synovium-Backus 
                 41.5 
               
               
                   
                 104692 (BA) OA Cartilage-Backus 
                 64.2 
               
               
                   
                 104694 (BA) OA Bone-Backus 
                 28.5 
               
               
                   
                 104695 (BA) Adj “Normal” Bone-Backus 
                 35.1 
               
               
                   
                 104696 (BA) OA Synovium-Backus 
                 28.7 
               
               
                   
                 104700 (SS) OA Bone-Backus 
                 18.8 
               
               
                   
                 104701 (SS) Adj “Normal” Bone-Backus 
                 29.5 
               
               
                   
                 104702 (SS) OA Synovium-Backus 
                 62.9 
               
               
                   
                 117093 OA Cartilage Rep7 
                 46.7 
               
               
                   
                 112672 OA Bone5 
                 74.7 
               
               
                   
                 112673 OA Synovium5 
                 28.9 
               
               
                   
                 112674 OA Synovial Fluid cells5 
                 28.5 
               
               
                   
                 117100 OA Cartilage Rep14 
                 20.7 
               
               
                   
                 112756 OA Bone9 
                 16.3 
               
               
                   
                 112757 OA Synovium9 
                 45.1 
               
               
                   
                 112758 OA Synovial Fluid Cells9 
                 14.4 
               
               
                   
                 117125 RA Cartilage Rep2 
                 77.9 
               
               
                   
                 113492 Bone2 RA 
                 24.8 
               
               
                   
                 113493 Synovium2 RA 
                 8.1 
               
               
                   
                 113494 Syn Fluid Cells RA 
                 14.3 
               
               
                   
                 113499 Cartilage4 RA 
                 18.3 
               
               
                   
                 113500 Bone4 RA 
                 22.5 
               
               
                   
                 113501 Synovium4 RA 
                 14.1 
               
               
                   
                 113502 Syn Fluid Cells4 RA 
                 10.7 
               
               
                   
                 113495 Cartilage3 RA 
                 17.0 
               
               
                   
                 113496 Bone3 RA 
                 19.8 
               
               
                   
                 113497 Synovium3 RA 
                 11.9 
               
               
                   
                 113498 Syn Fluid Cells3 RA 
                 28.1 
               
               
                   
                 117106 Normal Cartilage Rep20 
                 50.0 
               
               
                   
                 113663 Bone3 Normal 
                 3.3 
               
               
                   
                 113664 Synovium3 Normal 
                 1.1 
               
               
                   
                 113665 Syn Fluid Cells3 Normal 
                 2.0 
               
               
                   
                 117107 Normal Cartilage Rep22 
                 6.4 
               
               
                   
                 113667 Bone4 Normal 
                 21.6 
               
               
                   
                 113668 Synovium4 Normal 
                 24.8 
               
               
                   
                 113669 Syn Fluid Cells4 Normal 
                 48.6 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2779, Run 249247310    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE SC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 3.5 
               
               
                   
                 Pancreas 
                 1.2 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.3 
               
               
                   
                 Adrenal gland 
                 3.7 
               
               
                   
                 Thyroid 
                 12.1 
               
               
                   
                 Salivary gland 
                 2.1 
               
               
                   
                 Pituitary gland 
                 14.9 
               
               
                   
                 Brain (fetal) 
                 0.6 
               
               
                   
                 Brain (whole) 
                 4.0 
               
               
                   
                 Brain (amygdala) 
                 7.0 
               
               
                   
                 Brain (cerebellum) 
                 2.1 
               
               
                   
                 Brain (hippocampus) 
                 11.0 
               
               
                   
                 Brain (substantia nigra) 
                 2.5 
               
               
                   
                 Brain (thalamus) 
                 6.4 
               
               
                   
                 Cerebral Cortex 
                 10.0 
               
               
                   
                 Spinal cord 
                 17.2 
               
               
                   
                 glio/astro U87-MG 
                 2.8 
               
               
                   
                 glio/astro U-118-MG 
                 1.6 
               
               
                   
                 astrocytoma SW1783 
                 2.9 
               
               
                   
                 neuro*; met SK-N-AS 
                 2.2 
               
               
                   
                 astrocytoma SF-539 
                 3.3 
               
               
                   
                 astrocytoma SNB-75 
                 2.6 
               
               
                   
                 glioma SNB-19 
                 3.2 
               
               
                   
                 glioma U251 
                 2.5 
               
               
                   
                 glioma SF-295 
                 4.6 
               
               
                   
                 Heart (fetal) 
                 15.8 
               
               
                   
                 Heart 
                 4.1 
               
               
                   
                 Skeletal muscle (fetal) 
                 100.0 
               
               
                   
                 Skeletal muscle 
                 24.8 
               
               
                   
                 Bone marrow 
                 1.7 
               
               
                   
                 Thymus 
                 30.8 
               
               
                   
                 Spleen 
                 11.3 
               
               
                   
                 Lymph node 
                 5.9 
               
               
                   
                 Colorectal 
                 8.5 
               
               
                   
                 Stomach 
                 4.2 
               
               
                   
                 Small intestine 
                 7.7 
               
               
                   
                 Colon ca. SW480 
                 0.5 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 0.4 
               
               
                   
                 Colon ca. HT29 
                 1.5 
               
               
                   
                 Colon ca. HCT-116 
                 0.3 
               
               
                   
                 Colon ca. CaCo-2 
                 3.0 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 2.8 
               
               
                   
                 Colon ca. HCC-2998 
                 0.9 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 1.6 
               
               
                   
                 Bladder 
                 3.3 
               
               
                   
                 Trachea 
                 11.8 
               
               
                   
                 Kidney 
                 9.2 
               
               
                   
                 Kidney (fetal) 
                 6.4 
               
               
                   
                 Renal ca. 786-0 
                 1.8 
               
               
                   
                 Renal ca. A498 
                 3.3 
               
               
                   
                 Renal ca. RXF 393 
                 1.6 
               
               
                   
                 Renal ca. ACHN 
                 2.2 
               
               
                   
                 Renal ca. UO-31 
                 1.2 
               
               
                   
                 Renal ca. TK-10 
                 1.0 
               
               
                   
                 Liver 
                 1.0 
               
               
                   
                 Liver (fetal) 
                 2.7 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 1.4 
               
               
                   
                 Lung 
                 6.4 
               
               
                   
                 Lung (fetal) 
                 4.9 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.4 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.2 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 1.6 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.6 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.6 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 4.8 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 4.3 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.5 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 3.5 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.2 
               
               
                   
                 Mammary gland 
                 5.1 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 3.3 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.9 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 3.2 
               
               
                   
                 Breast ca. BT-549 
                 2.2 
               
               
                   
                 Breast ca. MDA-N 
                 0.5 
               
               
                   
                 Ovary 
                 40.1 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 2.5 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.4 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 1.7 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 1.3 
               
               
                   
                 Ovarian ca. IGROV-1 
                 1.1 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.5 
               
               
                   
                 Uterus 
                 4.6 
               
               
                   
                 Placenta 
                 5.1 
               
               
                   
                 Prostate 
                 5.4 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 1.6 
               
               
                   
                 Testis 
                 8.6 
               
               
                   
                 Melanoma Hs688(A).T 
                 1.5 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 2.3 
               
               
                   
                 Melanoma UACC-62 
                 0.8 
               
               
                   
                 Melanoma M14 
                 0.4 
               
               
                   
                 Melanoma LOX IMVI 
                 0.1 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 1.3 
               
               
                   
                 Adipose 
                 6.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2779, Run 164024255    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE SD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 33.4 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 4.2 
               
               
                   
                 CC Margin (ODO3866) 
                 10.7 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 6.0 
               
               
                   
                 CC Margin (ODO3868) 
                 7.5 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 5.8 
               
               
                   
                 CC Margin (ODO3920) 
                 18.2 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 15.9 
               
               
                   
                 CC Margin (ODO3921) 
                 9.9 
               
               
                   
                 CC from Partial Hepatectomy (ODO4309) Mets 
                 22.4 
               
               
                   
                 Liver Margin (ODO4309) 
                 9.9 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 15.1 
               
               
                   
                 Lung Margin (OD04451-02) 
                 11.7 
               
               
                   
                 Normal Prostate 6546-1 
                 100.0 
               
               
                   
                 Prostate Cancer (OD04410) 
                 14.0 
               
               
                   
                 Prostate Margin (OD04410) 
                 30.8 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 25.0 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 28.9 
               
               
                   
                 Normal Lung 061010 
                 30.6 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 12.2 
               
               
                   
                 Muscle Margin (ODO4286) 
                 52.9 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 71.2 
               
               
                   
                 Lung Margin (OD03126) 
                 23.0 
               
               
                   
                 Lung Cancer (OD04404) 
                 11.9 
               
               
                   
                 Lung Margin (OD04404) 
                 22.8 
               
               
                   
                 Lung Cancer (OD04565) 
                 17.8 
               
               
                   
                 Lung Margin (OD04565) 
                 15.4 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 24.0 
               
               
                   
                 Lung Margin (OD04237-02) 
                 16.0 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 13.8 
               
               
                   
                 Liver Margin (ODO4310) 
                 9.8 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 4.4 
               
               
                   
                 Lung Margin (OD04321) 
                 25.9 
               
               
                   
                 Normal Kidney 
                 31.6 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 53.2 
               
               
                   
                 Kidney Margin (OD04338) 
                 23.8 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 52.1 
               
               
                   
                 Kidney Margin (OD04339) 
                 32.8 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 40.6 
               
               
                   
                 Kidney Margin (OD04340) 
                 33.7 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 10.7 
               
               
                   
                 Kidney Margin (OD04348) 
                 16.0 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 32.5 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 10.9 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 27.5 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 25.0 
               
               
                   
                 Kidney Cancer 8120607 
                 17.4 
               
               
                   
                 Kidney Margin 8120608 
                 23.3 
               
               
                   
                 Kidney Cancer 8120613 
                 47.3 
               
               
                   
                 Kidney Margin 8120614 
                 15.6 
               
               
                   
                 Kidney Cancer 9010320 
                 15.2 
               
               
                   
                 Kidney Margin 9010321 
                 32.1 
               
               
                   
                 Normal Uterus 
                 13.5 
               
               
                   
                 Uterus Cancer 064011 
                 21.2 
               
               
                   
                 Normal Thyroid 
                 41.2 
               
               
                   
                 Thyroid Cancer 064010 
                 20.0 
               
               
                   
                 Thyroid Cancer A302152 
                 71.2 
               
               
                   
                 Thyroid Margin A302153 
                 32.5 
               
               
                   
                 Normal Breast 
                 28.7 
               
               
                   
                 Breast Cancer (OD04566) 
                 7.3 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 17.9 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 27.5 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 20.7 
               
               
                   
                 Breast Cancer 064006 
                 22.7 
               
               
                   
                 Breast Cancer 1024 
                 29.5 
               
               
                   
                 Breast Cancer 9100266 
                 32.5 
               
               
                   
                 Breast Margin 9100265 
                 17.9 
               
               
                   
                 Breast Cancer A209073 
                 21.8 
               
               
                   
                 Breast Margin A209073 
                 11.5 
               
               
                   
                 Normal Liver 
                 6.5 
               
               
                   
                 Liver Cancer 064003 
                 6.3 
               
               
                   
                 Liver Cancer 1025 
                 8.1 
               
               
                   
                 Liver Cancer 1026 
                 13.6 
               
               
                   
                 Liver Cancer 6004-T 
                 7.0 
               
               
                   
                 Liver Tissue 6004-N 
                 12.2 
               
               
                   
                 Liver Cancer 6005-T 
                 10.6 
               
               
                   
                 Liver Tissue 6005-N 
                 4.0 
               
               
                   
                 Normal Bladder 
                 15.4 
               
               
                   
                 Bladder Cancer 1023 
                 6.6 
               
               
                   
                 Bladder Cancer A302173 
                 4.9 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 11.2 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 28.5 
               
               
                   
                 Normal Ovary 
                 32.1 
               
               
                   
                 Ovarian Cancer 064008 
                 26.8 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 37.4 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 16.7 
               
               
                   
                 Normal Stomach 
                 35.6 
               
               
                   
                 Gastric Cancer 9060358 
                 9.1 
               
               
                   
                 Stomach Margin 9060359 
                 24.8 
               
               
                   
                 Gastric Cancer 9060395 
                 28.3 
               
               
                   
                 Stomach Margin 9060394 
                 26.4 
               
               
                   
                 Gastric Cancer 9060397 
                 15.8 
               
               
                   
                 Stomach Margin 9060396 
                 10.6 
               
               
                   
                 Gastric Cancer 064005 
                 21.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2779, Run 162555295    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE SE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 13.4 
               
               
                   
                 Secondary Th2 act 
                 8.4 
               
               
                   
                 Secondary Tr1 act 
                 11.0 
               
               
                   
                 Secondary Th1 rest 
                 37.1 
               
               
                   
                 Secondary Th2 rest 
                 49.0 
               
               
                   
                 Secondary Tr1 rest 
                 49.3 
               
               
                   
                 Primary Th1 act 
                 4.7 
               
               
                   
                 Primary Th2 act 
                 1.9 
               
               
                   
                 Primary Tr1 act 
                 9.0 
               
               
                   
                 Primary Th1 rest 
                 91.4 
               
               
                   
                 Primary Th2 rest 
                 81.8 
               
               
                   
                 Primary Tr1 rest 
                 35.6 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 4.1 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 15.6 
               
               
                   
                 CD8 lymphocyte act 
                 11.9 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 9.7 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 8.6 
               
               
                   
                 CD4 lymphocyte none 
                 49.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 89.5 
               
               
                   
                 LAK cells rest 
                 17.3 
               
               
                   
                 LAK cells IL-2 
                 36.1 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 17.1 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 28.7 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 23.5 
               
               
                   
                 LAK cells PMA/ionomycin 
                 4.9 
               
               
                   
                 NK Cells IL-2 rest 
                 26.2 
               
               
                   
                 Two Way MLR 3 day 
                 31.9 
               
               
                   
                 Two Way MLR 5 day 
                 15.4 
               
               
                   
                 Two Way MLR 7 day 
                 27.4 
               
               
                   
                 PBMC rest 
                 39.8 
               
               
                   
                 PBMC PWM 
                 29.5 
               
               
                   
                 PBMC PHA-L 
                 16.5 
               
               
                   
                 Ramos (B cell) none 
                 5.8 
               
               
                   
                 Ramos (B cell) ionomycin 
                 14.1 
               
               
                   
                 B lymphocytes PWM 
                 25.9 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 36.1 
               
               
                   
                 EOL-1 dbcAMP 
                 9.8 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 4.7 
               
               
                   
                 Dendritic cells none 
                 12.1 
               
               
                   
                 Dendritic cells LPS 
                 9.9 
               
               
                   
                 Dendritic cells anti-CD40 
                 9.0 
               
               
                   
                 Monocytes rest 
                 12.9 
               
               
                   
                 Monocytes LPS 
                 3.7 
               
               
                   
                 Macrophages rest 
                 10.2 
               
               
                   
                 Macrophages LPS 
                 5.5 
               
               
                   
                 HUVEC none 
                 17.1 
               
               
                   
                 HUVEC starved 
                 29.3 
               
               
                   
                 HUVEC IL-1beta 
                 4.3 
               
               
                   
                 HUVEC IFN gamma 
                 23.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 4.2 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 7.1 
               
               
                   
                 HUVEC IL-11 
                 18.4 
               
               
                   
                 Lung Microvascular EC none 
                 18.2 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 15.1 
               
               
                   
                 Microvascular Dermal EC none 
                 29.5 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 9.4 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 20.4 
               
               
                   
                 Small airway epithelium none 
                 5.0 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 21.0 
               
               
                   
                 Coronery artery SMC rest 
                 24.3 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 18.3 
               
               
                   
                 Astrocytes rest 
                 34.2 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 29.1 
               
               
                   
                 KU-812 (Basophil) rest 
                 5.8 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 10.5 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 4.7 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 4.3 
               
               
                   
                 Liver cirrhosis 
                 7.6 
               
               
                   
                 Lupus kidney 
                 11.5 
               
               
                   
                 NCI-H292 none 
                 15.3 
               
               
                   
                 NCI-H292 IL-4 
                 8.9 
               
               
                   
                 NCI-H292 IL-9 
                 11.0 
               
               
                   
                 NCI-H292 IL-13 
                 6.3 
               
               
                   
                 NCI-H292 IFN gamma 
                 6.0 
               
               
                   
                 HPAEC none 
                 26.2 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 11.5 
               
               
                   
                 Lung fibroblast none 
                 27.4 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 66.0 
               
               
                   
                 Lung fibroblast IL-4 
                 25.2 
               
               
                   
                 Lung fibroblast IL-9 
                 22.4 
               
               
                   
                 Lung fibroblast IL-13 
                 18.3 
               
               
                   
                 Lung fibroblast IFN gamma 
                 34.9 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 8.8 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 49.3 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 4.9 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 4.9 
               
               
                   
                 Dermal fibroblast IL-4 
                 11.2 
               
               
                   
                 IBD Colitis 2 
                 5.1 
               
               
                   
                 IBD Crohn&#39;s 
                 11.1 
               
               
                   
                 Colon 
                 42.6 
               
               
                   
                 Lung 
                 26.8 
               
               
                   
                 Thymus 
                 41.5 
               
               
                   
                 Kidney 
                 100.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2779, Run 162188258    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE SF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 5D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 97457_Patient-02go_adipose 
                 30.1 
               
               
                   
                 97476_Patient-07sk_skeletal muscle 
                 13.8 
               
               
                   
                 97477_Patient-07ut_uterus 
                 31.0 
               
               
                   
                 97478_Patient-07pl_placenta 
                 17.4 
               
               
                   
                 97481_Patient-08sk_skeletal muscle 
                 38.7 
               
               
                   
                 97482_Patient-08ut_uterus 
                 45.4 
               
               
                   
                 97483_Patient-08pl_placenta 
                 16.0 
               
               
                   
                 97486_Patient-09sk_skeletal muscle 
                 7.4 
               
               
                   
                 97487_Patient-09ut_uterus 
                 19.8 
               
               
                   
                 97488_Patient-09pl_placenta 
                 16.7 
               
               
                   
                 97492_Patient-10ut_uterus 
                 66.4 
               
               
                   
                 97493_Patient-10pl_placenta 
                 46.3 
               
               
                   
                 97495_Patient-11go_adipose 
                 7.2 
               
               
                   
                 97496_Patient-11sk_skeletal muscle 
                 12.4 
               
               
                   
                 97497_Patient-11ut_uterus 
                 68.3 
               
               
                   
                 97498_Patient-11pl_placenta 
                 26.4 
               
               
                   
                 97500_Patient-12go_adipose 
                 35.8 
               
               
                   
                 97501_Patient-12sk_skeletal muscle 
                 78.5 
               
               
                   
                 97502_Patient-12ut_uterus 
                 100.0 
               
               
                   
                 97503_Patient-12pl_placenta 
                 21.5 
               
               
                   
                 94721_Donor 2 U - A_Mesenchymal Stem Cells 
                 23.3 
               
               
                   
                 94722_Donor 2 U - B_Mesenchymal Stem Cells 
                 28.1 
               
               
                   
                 94723_Donor 2 U - C_Mesenchymal Stem Cells 
                 20.0 
               
               
                   
                 94709_Donor 2 AM - A_adipose 
                 16.0 
               
               
                   
                 94710_Donor 2 AM - B_adipose 
                 15.1 
               
               
                   
                 94711_Donor 2 AM - C_adipose 
                 7.9 
               
               
                   
                 94712_Donor 2 AD - A_adipose 
                 32.1 
               
               
                   
                 94713_Donor 2 AD - B_adipose 
                 40.1 
               
               
                   
                 94714_Donor 2 AD - C_adipose 
                 35.1 
               
               
                   
                 94742_Donor 3 U - A_Mesenchymal Stem Cells 
                 10.1 
               
               
                   
                 94743_Donor 3 U - B_Mesenchymal Stem Cells 
                 14.1 
               
               
                   
                 94730_Donor 3 AM - A_adipose 
                 13.5 
               
               
                   
                 94731_Donor 3 AM - B_adipose 
                 8.8 
               
               
                   
                 94732_Donor 3 AM - C_adipose 
                 5.2 
               
               
                   
                 94733_Donor 3 AD - A_adipose 
                 26.6 
               
               
                   
                 94734_Donor 3 AD - B_adipose 
                 17.4 
               
               
                   
                 94735_Donor 3 AD - C_adipose 
                 26.1 
               
               
                   
                 77138_Liver_HepG2untreated 
                 25.0 
               
               
                   
                 73556_Heart_Cardiac stromal cells (primary) 
                 7.3 
               
               
                   
                 81735_Small Intestine 
                 55.5 
               
               
                   
                 72409_Kidney_Proximal Convoluted Tubule 
                 4.2 
               
               
                   
                 82685_Small intestine_Duodenum 
                 21.2 
               
               
                   
                 90650_Adrenal_Adrenocortical adenoma 
                 30.1 
               
               
                   
                 72410_Kidney_HRCE 
                 25.7 
               
               
                   
                 72411_Kidney_HRE 
                 14.3 
               
               
                   
                 73139_Uterus_Uterine smooth muscle cells 
                 14.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2779, Run 255179443    
               
            
           
         
       
     
      AI_comprehensive panel_v1.0 Summary: Ag2779 Highest expression of this gene was detected in normal lung (CT=27). Moderate levels of expression of this gene were detected in samples derived from osteoarthritic (OA) bone and normal adjacent bone as well as OA cartilage, OA synovium and OA synovial fluid samples. Moderate to low levels of expression were also detected in cartilage, bone, synovium and synovial fluid samples from rheumatoid arthritis patients as well as in samples derived from normal lung samples, COPD lung, emphysema, atopic asthma, asthma, allergy, Crohn&#39;s disease (normal matched control and diseased), ulcerative colitis(normal matched control and diseased), and psoriasis (normal matched control and diseased). Therapeutic modulation of this gene or gene product is useful for the amelioration of symptoms/conditions associated with autoimmune and inflammatory disorders including psoriasis, allergy, asthma, inflammatory bowel disease, rheumatoid arthritis and osteoarthritis.  
      Panel 1.3D Summary: Ag2779 Highest expression was seen in fetal skeletal muscle (CT=25). Prominent expression was seen in normal tissues including ovary and bone marrow.  
      Panel 2D Summary: Ag2779 Highest expression was seen in prostate (CT=23.5). High levels of expression were seen in most of the samples on this panel, showing that this gene or its protein product plays a role in cell growth and/or proliferation.  
      Panel 4D Summary: Ag2779 Highest expression was seen in the kidney (CT=26.7). In addition, this gene was more highly expressed in resting T cells (Th1, Th2, Tr1) than in activated T cells. Thus, this gene is be involved in T lymphocyte function. Therapeutics targeting this gene or its protein product are useful for the stimulation of their activity and act as anti-inflammatory therapeutic for T cell-mediated autoimmune and inflammatory diseases.  
      Panel SD Summary: Ag2779 Highest expression was seen in normal uterus (CT=27), with prominent expression in normal adipose and placenta. This strong expression in normal tissues was in agreement with the results in Panel 1.3D.  
      T. CG52979-03 and CG52988-02 and CG52988-03: GAGE  
      Expression of gene CG52979-03, variant CG52988-02 and full-length physical clone CG52988-03 was assessed using the primer-probe sets Ag436b, and Ag436, described in Tables TA and TB. Results of the RTQ-PCR runs are shown in Tables TC, TD, TE, TF, TG and TH.  
               TABLE TA                          Probe Name Ag436b                                 Primers   Sequences   Length   Start Position   SEQ ID No                                             Forward   5′-gagcctggagatggtcctga-3′   20   184   1339                   Probe   TET-5′-agatcaaaagtgggcataataccctccctga-3′-TAMRA   31   151   1340               Reverse   5′-atcacctgcttccagcactttagt-3′   24   126   1341                  
 
     
       
         
           
               
             
               
                 TABLE TB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag436 
               
            
           
           
               
               
               
               
               
            
               
                 Primers 
                 Sequences 
                 Length 
                 Start Position 
                 SEQ ID No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-gcctggagatggtcctgatg-3′ 
                 20 
                 182 
                 1342 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-tgagatcaaaagtgggcataataccctccct-3′-TAMRA 
                 31 
                 149 
                 1343 
               
               
                   
               
               
                 Reverse 
                 5′-catcacctgcttccagcactt-3′ 
                 21 
                 125 
                 1344 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE TC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Endothelial cells 
                 0.0 
               
               
                   
                 Endothelial cells (treated) 
                 0.0 
               
               
                   
                 Pancreas 
                 1.6 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
               
               
                   
                 Adrenal gland 
                 0.4 
               
               
                   
                 Thyroid 
                 0.0 
               
               
                   
                 Salivary gland 
                 0.1 
               
               
                   
                 Pituitary gland 
                 0.0 
               
               
                   
                 Brain (fetal) 
                 0.0 
               
               
                   
                 Brain (whole) 
                 0.0 
               
               
                   
                 Brain (amygdala) 
                 0.0 
               
               
                   
                 Brain (cerebellum) 
                 0.0 
               
               
                   
                 Brain (hippocampus) 
                 0.1 
               
               
                   
                 Brain (substantia nigra) 
                 0.1 
               
               
                   
                 Brain (thalamus) 
                 0.0 
               
               
                   
                 Brain (hypothalamus) 
                 0.4 
               
               
                   
                 Spinal cord 
                 0.3 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.9 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.3 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 0.0 
               
               
                   
                 glioma SNB-19 
                 0.1 
               
               
                   
                 glioma U251 
                 0.1 
               
               
                   
                 glioma SF-295 
                 4.5 
               
               
                   
                 Heart 
                 0.1 
               
               
                   
                 Skeletal muscle 
                 0.0 
               
               
                   
                 Bone marrow 
                 6.1 
               
               
                   
                 Thymus 
                 1.0 
               
               
                   
                 Spleen 
                 0.8 
               
               
                   
                 Lymph node 
                 1.4 
               
               
                   
                 Colon (ascending) 
                 3.3 
               
               
                   
                 Stomach 
                 0.3 
               
               
                   
                 Small intestine 
                 0.2 
               
               
                   
                 Colon ca. SW480 
                 0.1 
               
               
                   
                 Colon ca.* SW620 (SW480 met) 
                 0.1 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.1 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon ca. HCT-15 
                 0.2 
               
               
                   
                 Colon ca. HCC-2998 
                 0.2 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.2 
               
               
                   
                 Bladder 
                 0.0 
               
               
                   
                 Trachea 
                 0.2 
               
               
                   
                 Kidney 
                 0.2 
               
               
                   
                 Kidney (fetal) 
                 0.3 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Liver 
                 0.4 
               
               
                   
                 Liver (fetal) 
                 4.6 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.3 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Lung (fetal) 
                 0.0 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 1.3 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.8 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 1.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.5 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 1.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.2 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.3 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.2 
               
               
                   
                 Mammary gland 
                 1.3 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.5 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.5 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 100.0 
               
               
                   
                 Ovary 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 1.3 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 3.5 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 0.0 
               
               
                   
                 Uterus 
                 0.1 
               
               
                   
                 Placenta 
                 13.3 
               
               
                   
                 Prostate 
                 0.4 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.9 
               
               
                   
                 Testis 
                 79.0 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
               
               
                   
                 Melanoma M14 
                 0.1 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
               
               
                   
                 Melanoma SK-MEL-28 
                 8.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag436, Run 109664430    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE TD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.1 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Adrenal gland 
                 0.0 
                 0.0 
               
               
                   
                 Bladder 
                 0.1 
                 0.0 
               
               
                   
                 Brain (amygdala) 
                 0.0 
                 0.0 
               
               
                   
                 Brain (cerebellum) 
                 0.4 
                 0.0 
               
               
                   
                 Brain (hippocampus) 
                 0.0 
                 0.0 
               
               
                   
                 Brain (substantia nigra) 
                 0.4 
                 0.0 
               
               
                   
                 Brain (thalamus) 
                 0.0 
                 0.0 
               
               
                   
                 Cerebral Cortex 
                 0.0 
                 0.0 
               
               
                   
                 Brain (fetal) 
                 0.0 
                 0.0 
               
               
                   
                 Brain (whole) 
                 0.4 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.8 
                 0.1 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
                 0.0 
               
               
                   
                 glioma U251 
                 0.1 
                 0.0 
               
               
                   
                 glioma SF-295 
                 3.3 
                 4.2 
               
               
                   
                 glioma SNB-19 
                 0.2 
                 0.0 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.2 
                 0.0 
               
               
                   
                 Mammary gland 
                 0.1 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 100.0 
                 100.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.4 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
                 0.0 
               
               
                   
                 Small intestine 
                 0.3 
                 0.0 
               
               
                   
                 Colorectal 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.3 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.1 
                 0.0 
               
               
                   
                 Colon ca. HCT-15 
                 0.1 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.1 
                 0.0 
               
               
                   
                 Colon ca. HCC-2998 
                 0.2 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.1 
                 0.0 
               
               
                   
                 Colon ca.* SW620 (SW480 met) 
                 0.4 
                 0.0 
               
               
                   
                 Stomach 
                 0.4 
                 0.0 
               
               
                   
                 Gastric ca. (liver met) NCI-N87 
                 0.4 
                 0.0 
               
               
                   
                 Heart 
                 0.0 
                 0.0 
               
               
                   
                 Skeletal muscle (Fetal) 
                 0.0 
                 0.0 
               
               
                   
                 Skeletal muscle 
                 0.0 
                 0.0 
               
               
                   
                 Endothelial cells 
                 0.0 
                 0.0 
               
               
                   
                 Heart (Fetal) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney 
                 0.3 
                 0.0 
               
               
                   
                 Kidney (fetal) 
                 0.2 
                 0.0 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
                 0.0 
               
               
                   
                 Liver 
                 0.6 
                 0.0 
               
               
                   
                 Liver (fetal) 
                 1.5 
                 1.7 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.2 
                 0.0 
               
               
                   
                 Lung 
                 0.0 
                 0.0 
               
               
                   
                 Lung (fetal) 
                 0.3 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.4 
                 0.2 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.3 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.4 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 1.0 
                 0.3 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.2 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.2 
                 0.0 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 2.3 
                 0.0 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.9 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.2 
                 0.0 
               
               
                   
                 Lymph node 
                 0.4 
                 0.0 
               
               
                   
                 Spleen 
                 0.2 
                 0.0 
               
               
                   
                 Thymus 
                 0.4 
                 0.0 
               
               
                   
                 Ovary 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.9 
                 0.3 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.9 
                 0.2 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.0 
                 0.0 
               
               
                   
                 Pancreas 
                 2.4 
                 5.1 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
                 0.0 
               
               
                   
                 Pituitary gland 
                 0.2 
                 0.0 
               
               
                   
                 Placenta 
                 4.2 
                 3.8 
               
               
                   
                 Prostate 
                 0.5 
                 0.0 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.3 
                 0.0 
               
               
                   
                 Salivary gland 
                 0.2 
                 0.0 
               
               
                   
                 Trachea 
                 0.0 
                 0.0 
               
               
                   
                 Spinal cord 
                 0.2 
                 0.0 
               
               
                   
                 Testis 
                 44.4 
                 28.7 
               
               
                   
                 Thyroid 
                 0.0 
                 0.0 
               
               
                   
                 Uterus 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma M14 
                 0.2 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma SK-MEL-28 
                 0.1 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag436, Run 109665004    
               
               
                   
                   Column B - Rel. Exp. (%) Ag436b, Run 111165634    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE TE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 2.5 
               
               
                   
                 Pancreas 
                 0.8 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
               
               
                   
                 Adrenal gland 
                 0.0 
               
               
                   
                 Thyroid 
                 0.5 
               
               
                   
                 Salivary gland 
                 0.0 
               
               
                   
                 Pituitary gland 
                 0.6 
               
               
                   
                 Brain (fetal) 
                 3.5 
               
               
                   
                 Brain (whole) 
                 1.6 
               
               
                   
                 Brain (amygdala) 
                 0.0 
               
               
                   
                 Brain (cerebellum) 
                 2.2 
               
               
                   
                 Brain (hippocampus) 
                 2.9 
               
               
                   
                 Brain (substantia nigra) 
                 2.1 
               
               
                   
                 Brain (thalamus) 
                 0.7 
               
               
                   
                 Cerebral Cortex 
                 1.4 
               
               
                   
                 Spinal cord 
                 0.0 
               
               
                   
                 glio/astro U87-MG 
                 1.0 
               
               
                   
                 glio/astro U-118-MG 
                 5.1 
               
               
                   
                 astrocytoma SW1783 
                 4.3 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.7 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 0.0 
               
               
                   
                 glioma SNB-19 
                 0.8 
               
               
                   
                 glioma U251 
                 0.3 
               
               
                   
                 glioma SF-295 
                 5.6 
               
               
                   
                 Heart (fetal) 
                 0.8 
               
               
                   
                 Heart 
                 0.0 
               
               
                   
                 Skeletal muscle (fetal) 
                 0.0 
               
               
                   
                 Skeletal muscle 
                 0.0 
               
               
                   
                 Bone marrow 
                 16.7 
               
               
                   
                 Thymus 
                 0.7 
               
               
                   
                 Spleen 
                 1.4 
               
               
                   
                 Lymph node 
                 3.7 
               
               
                   
                 Colorectal 
                 1.1 
               
               
                   
                 Stomach 
                 1.1 
               
               
                   
                 Small intestine 
                 1.3 
               
               
                   
                 Colon ca. SW480 
                 0.7 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 1.0 
               
               
                   
                 Colon ca. HT29 
                 2.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.7 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 0.0 
               
               
                   
                 Colon ca. HCC-2998 
                 0.7 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.0 
               
               
                   
                 Bladder 
                 0.0 
               
               
                   
                 Trachea 
                 0.0 
               
               
                   
                 Kidney 
                 0.8 
               
               
                   
                 Kidney (fetal) 
                 3.3 
               
               
                   
                 Renal ca. 786-0 
                 1.0 
               
               
                   
                 Renal ca. A498 
                 1.0 
               
               
                   
                 Renal ca. RXF 393 
                 1.7 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Liver 
                 2.2 
               
               
                   
                 Liver (fetal) 
                 11.6 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
               
               
                   
                 Lung 
                 2.7 
               
               
                   
                 Lung (fetal) 
                 4.0 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 2.5 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 8.4 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 2.8 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.9 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 1.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
               
               
                   
                 Mammary gland 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 1.7 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 76.8 
               
               
                   
                 Ovary 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 3.1 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.8 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 2.5 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.9 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 1.7 
               
               
                   
                 Uterus 
                 0.0 
               
               
                   
                 Placenta 
                 6.3 
               
               
                   
                 Prostate 
                 1.3 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 1.7 
               
               
                   
                 Testis 
                 100.0 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.9 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
               
               
                   
                 Melanoma M14 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 2.0 
               
               
                   
                 Adipose 
                 2.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag436, Run 153954656    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE TF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 0.0 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 0.9 
               
               
                   
                 CC Margin (ODO3866) 
                 0.9 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 0.0 
               
               
                   
                 CC Margin (ODO3868) 
                 0.8 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 0.5 
               
               
                   
                 CC Margin (ODO3920) 
                 0.4 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 0.9 
               
               
                   
                 CC Margin (ODO3921) 
                 0.5 
               
               
                   
                 CC from Partial Hepatectomy (ODO4309) Mets 
                 1.7 
               
               
                   
                 Liver Margin (ODO4309) 
                 0.8 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 0.8 
               
               
                   
                 Lung Margin (OD04451-02) 
                 0.0 
               
               
                   
                 Normal Prostate 6546-1 
                 1.4 
               
               
                   
                 Prostate Cancer (OD04410) 
                 1.5 
               
               
                   
                 Prostate Margin (OD04410) 
                 0.3 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 1.6 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 1.0 
               
               
                   
                 Normal Lung 061010 
                 1.4 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 0.6 
               
               
                   
                 Muscle Margin (ODO4286) 
                 0.7 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 0.0 
               
               
                   
                 Lung Margin (OD03126) 
                 0.6 
               
               
                   
                 Lung Cancer (OD04404) 
                 0.0 
               
               
                   
                 Lung Margin (OD04404) 
                 0.0 
               
               
                   
                 Lung Cancer (OD04565) 
                 0.6 
               
               
                   
                 Lung Margin (OD04565) 
                 0.7 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 0.9 
               
               
                   
                 Lung Margin (OD04237-02) 
                 0.2 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 0.0 
               
               
                   
                 Liver Margin (ODO4310) 
                 0.2 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.6 
               
               
                   
                 Lung Margin (OD04321) 
                 0.4 
               
               
                   
                 Normal Kidney 
                 1.0 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 0.2 
               
               
                   
                 Kidney Margin (OD04338) 
                 2.0 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 0.4 
               
               
                   
                 Kidney Margin (OD04339) 
                 0.6 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 0.4 
               
               
                   
                 Kidney Margin (OD04340) 
                 0.2 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.3 
               
               
                   
                 Kidney Margin (OD04348) 
                 0.0 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 0.3 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 0.0 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 0.5 
               
               
                   
                 Kidney Cancer 8120607 
                 0.0 
               
               
                   
                 Kidney Margin 8120608 
                 0.2 
               
               
                   
                 Kidney Cancer 8120613 
                 0.2 
               
               
                   
                 Kidney Margin 8120614 
                 0.0 
               
               
                   
                 Kidney Cancer 9010320 
                 56.6 
               
               
                   
                 Kidney Margin 9010321 
                 0.0 
               
               
                   
                 Normal Uterus 
                 0.0 
               
               
                   
                 Uterus Cancer 064011 
                 0.7 
               
               
                   
                 Normal Thyroid 
                 0.4 
               
               
                   
                 Thyroid Cancer 064010 
                 0.0 
               
               
                   
                 Thyroid Cancer A302152 
                 0.3 
               
               
                   
                 Thyroid Margin A302153 
                 0.3 
               
               
                   
                 Normal Breast 
                 0.4 
               
               
                   
                 Breast Cancer (OD04566) 
                 1.3 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 1.1 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 2.7 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 3.5 
               
               
                   
                 Breast Cancer 064006 
                 37.9 
               
               
                   
                 Breast Cancer 1024 
                 1.1 
               
               
                   
                 Breast Cancer 9100266 
                 0.4 
               
               
                   
                 Breast Margin 9100265 
                 0.4 
               
               
                   
                 Breast Cancer A209073 
                 1.0 
               
               
                   
                 Breast Margin A209073 
                 0.9 
               
               
                   
                 Normal Liver 
                 0.0 
               
               
                   
                 Liver Cancer 064003 
                 0.3 
               
               
                   
                 Liver Cancer 1025 
                 0.0 
               
               
                   
                 Liver Cancer 1026 
                 0.0 
               
               
                   
                 Liver Cancer 6004-T 
                 0.2 
               
               
                   
                 Liver Tissue 6004-N 
                 1.0 
               
               
                   
                 Liver Cancer 6005-T 
                 0.2 
               
               
                   
                 Liver Tissue 6005-N 
                 0.6 
               
               
                   
                 Normal Bladder 
                 0.3 
               
               
                   
                 Bladder Cancer 1023 
                 0.0 
               
               
                   
                 Bladder Cancer A302173 
                 100.0 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 2.8 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 0.6 
               
               
                   
                 Normal Ovary 
                 0.0 
               
               
                   
                 Ovarian Cancer 064008 
                 1.0 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 2.1 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 0.6 
               
               
                   
                 Normal Stomach 
                 0.9 
               
               
                   
                 Gastric Cancer 9060358 
                 0.3 
               
               
                   
                 Stomach Margin 9060359 
                 0.8 
               
               
                   
                 Gastric Cancer 9060395 
                 0.5 
               
               
                   
                 Stomach Margin 9060394 
                 0.0 
               
               
                   
                 Gastric Cancer 9060397 
                 1.4 
               
               
                   
                 Stomach Margin 9060396 
                 0.0 
               
               
                   
                 Gastric Cancer 064005 
                 0.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag436, Run 153954657    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE TG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Daoy- Medulloblastoma 
                 0.0 
               
               
                   
                 TE671- Medulloblastoma 
                 0.0 
               
               
                   
                 D283 Med- Medulloblastoma 
                 0.1 
               
               
                   
                 PFSK-1- Primitive Neuroectodermal 
                 0.0 
               
               
                   
                 XF-498- CNS 
                 0.2 
               
               
                   
                 SNB-78- Glioma 
                 0.0 
               
               
                   
                 SF-268- Glioblastoma 
                 0.0 
               
               
                   
                 T98G- Glioblastoma 
                 0.1 
               
               
                   
                 SK-N-SH- Neuroblastoma (metastasis) 
                 0.5 
               
               
                   
                 SF-295- Glioblastoma 
                 0.5 
               
               
                   
                 Cerebellum 
                 0.2 
               
               
                   
                 Cerebellum 
                 0.0 
               
               
                   
                 NCI-H292- Mucoepidermoid lung carcinoma 
                 0.0 
               
               
                   
                 DMS-114- Small cell lung cancer 
                 0.0 
               
               
                   
                 DMS-79- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H146- Small cell lung cancer 
                 16.0 
               
               
                   
                 NCI-H526- Small cell lung cancer 
                 0.1 
               
               
                   
                 NCI-N417- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H82- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H157- Squamous cell lung cancer (metastasis) 
                 0.0 
               
               
                   
                 NCI-H1155- Large cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H1299- Large cell lung cancer 
                 7.6 
               
               
                   
                 NCI-H727- Lung carcinoid 
                 0.1 
               
               
                   
                 NCI-UMC-11- Lung carcinoid 
                 0.1 
               
               
                   
                 LX-1- Small cell lung cancer 
                 0.0 
               
               
                   
                 Colo-205- Colon cancer 
                 0.1 
               
               
                   
                 KM12- Colon cancer 
                 0.0 
               
               
                   
                 KM20L2- Colon cancer 
                 0.0 
               
               
                   
                 NCI-H716- Colon cancer 
                 0.0 
               
               
                   
                 SW-48- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW1116- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 LS 174T- Colon adenocarcinoma 
                 0.1 
               
               
                   
                 SW-948- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-480- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-5- Gastric carcinoma 
                 0.0 
               
               
                   
                 KATO III- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-16- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-1- Gastric carcinoma 
                 0.0 
               
               
                   
                 RF-1- Gastric adenocarcinoma 
                 0.0 
               
               
                   
                 RF-48- Gastric adenocarcinoma 
                 0.0 
               
               
                   
                 MKN-45- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-N87- Gastric carcinoma 
                 0.0 
               
               
                   
                 OVCAR-5- Ovarian carcinoma 
                 0.0 
               
               
                   
                 RL95-2- Uterine carcinoma 
                 0.0 
               
               
                   
                 HelaS3- Cervical adenocarcinoma 
                 0.0 
               
               
                   
                 Ca Ski- Cervical epidermoid carcinoma (metastasis) 
                 0.0 
               
               
                   
                 ES-2- Ovarian clear cell carcinoma 
                 0.0 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 0.1 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 0.0 
               
               
                   
                 MEG-01- Chronic myelogenous leukemia 
                 0.1 
               
               
                   
                 (megokaryoblast) 
               
               
                   
                 Raji- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 Daudi- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 U266- B-cell plasmacytoma 
                 100.0 
               
               
                   
                 CA46- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 0.0 
               
               
                   
                 JM1- pre-B-cell lymphoma 
                 0.0 
               
               
                   
                 Jurkat- T cell leukemia 
                 0.0 
               
               
                   
                 TF-1- Erythroleukemia 
                 0.0 
               
               
                   
                 HUT 78- T-cell lymphoma 
                 0.0 
               
               
                   
                 U937- Histiocytic lymphoma 
                 0.0 
               
               
                   
                 KU-812- Myelogenous leukemia 
                 0.5 
               
               
                   
                 769-P- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 Caki-2- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 SW 839- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 Rhabdoid kidney tumor 
                 0.0 
               
               
                   
                 Hs766T- Pancreatic carcinoma (LN metastasis) 
                 0.0 
               
               
                   
                 CAPAN-1- Pancreatic adenocarcinoma (liver 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 SU86.86- Pancreatic carcinoma (liver 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 BxPC-3- Pancreatic adenocarcinoma 
                 0.0 
               
               
                   
                 HPAC- Pancreatic adenocarcinoma 
                 0.0 
               
               
                   
                 MIA PaCa-2- Pancreatic carcinoma 
                 0.0 
               
               
                   
                 CFPAC-1- Pancreatic ductal adenocarcinoma 
                 0.1 
               
               
                   
                 PANC-1- Pancreatic epithelioid ductal 
                 0.0 
               
               
                   
                 carcinoma 
               
               
                   
                 T24- Bladder carcinma (transitional cell) 
                 0.0 
               
               
                   
                 5637- Bladder carcinoma 
                 0.0 
               
               
                   
                 HT-1197- Bladder carcinoma 
                 0.0 
               
               
                   
                 UM-UC-3- Bladder carcinma (transitional cell) 
                 0.0 
               
               
                   
                 A204- Rhabdomyosarcoma 
                 0.1 
               
               
                   
                 HT-1080- Fibrosarcoma 
                 0.0 
               
               
                   
                 MG-63- Osteosarcoma 
                 0.0 
               
               
                   
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 0.0 
               
               
                   
                 SJRH30- Rhabdomyosarcoma (met to bone marrow) 
                 0.0 
               
               
                   
                 A431- Epidermoid carcinoma 
                 0.0 
               
               
                   
                 WM266-4- Melanoma 
                 0.0 
               
               
                   
                 DU 145- Prostate carcinoma (brain metastasis) 
                 0.1 
               
               
                   
                 MDA-MB-468- Breast adenocarcinoma 
                 0.1 
               
               
                   
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-9- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.1 
               
               
                   
                 CAL 27- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag436, Run 168238445    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE TH 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 18.6 
               
               
                   
                 Secondary Th1 rest 
                 22.7 
               
               
                   
                 Secondary Th2 rest 
                 22.5 
               
               
                   
                 Secondary Tr1 rest 
                 6.8 
               
               
                   
                 Primary Th1 act 
                 19.5 
               
               
                   
                 Primary Th2 act 
                 22.1 
               
               
                   
                 Primary Tr1 act 
                 35.8 
               
               
                   
                 Primary Th1 rest 
                 47.6 
               
               
                   
                 Primary Th2 rest 
                 62.0 
               
               
                   
                 Primary Tr1 rest 
                 12.9 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 16.8 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 29.9 
               
               
                   
                 CD8 lymphocyte act 
                 43.2 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 9.9 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 34.4 
               
               
                   
                 CD4 lymphocyte none 
                 24.5 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 26.8 
               
               
                   
                 LAK cells rest 
                 30.4 
               
               
                   
                 LAK cells IL-2 
                 41.2 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 8.5 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 44.8 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 40.9 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 27.0 
               
               
                   
                 Two Way MLR 3 day 
                 34.2 
               
               
                   
                 Two Way MLR 5 day 
                 9.3 
               
               
                   
                 Two Way MLR 7 day 
                 33.0 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 62.4 
               
               
                   
                 PBMC PHA-L 
                 54.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 17.6 
               
               
                   
                 B lymphocytes PWM 
                 11.5 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 10.6 
               
               
                   
                 EOL-1 dbcAMP 
                 6.2 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 8.4 
               
               
                   
                 Dendritic cells LPS 
                 11.1 
               
               
                   
                 Dendritic cells anti-CD40 
                 7.6 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 9.3 
               
               
                   
                 Macrophages rest 
                 9.3 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 10.2 
               
               
                   
                 HUVEC IL-1beta 
                 19.1 
               
               
                   
                 HUVEC IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 6.8 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 19.3 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 31.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
               
               
                   
                 Small airway epithelium none 
                 0.0 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 18.2 
               
               
                   
                 Coronery artery SMC rest 
                 0.0 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Astrocytes rest 
                 0.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 KU-812 (Basophil) rest 
                 89.5 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 95.3 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 5.8 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Liver cirrhosis 
                 35.6 
               
               
                   
                 Lupus kidney 
                 0.0 
               
               
                   
                 NCI-H292 none 
                 8.9 
               
               
                   
                 NCI-H292 IL-4 
                 22.5 
               
               
                   
                 NCI-H292 IL-9 
                 39.0 
               
               
                   
                 NCI-H292 IL-13 
                 0.0 
               
               
                   
                 NCI-H292 IFN gamma 
                 16.6 
               
               
                   
                 HPAEC none 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 21.2 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 27.5 
               
               
                   
                 Lung fibroblast IL-4 
                 0.0 
               
               
                   
                 Lung fibroblast IL-9 
                 11.4 
               
               
                   
                 Lung fibroblast IL-13 
                 0.0 
               
               
                   
                 Lung fibroblast IFN gamma 
                 20.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 4.2 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 41.2 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 11.3 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 0.0 
               
               
                   
                 IBD Colitis 2 
                 10.1 
               
               
                   
                 IBD Crohn&#39;s 
                 0.0 
               
               
                   
                 Colon 
                 33.0 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Thymus 
                 28.7 
               
               
                   
                 Kidney 
                 100.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag436, Run 153954658    
               
            
           
         
       
     
      Panel 1 Summary: Ag436 Expression of this gene was highest in a breast cancer cell line, showing that this gene plays a role in the development and/or progression of breast cancer. This gene was also expressed at fairly high levels in pancreas, and testis. Expression in pancreas demonstrates that this gene or gene product is involved in metabolic diseases such as diabetes and obesity.  
      Panel 1.1 Summary: Ag436b The expression of this gene was highest in testes and one breast cancer cell line. Expression of this gene is useful as a unique and specific marker for normal testis tissue. Therapeutic modulation of this gene or gene product through the use of protein, antibody, or small molecule therapeutics is useful as a therapeutic for breast cancer.  
      Panel 1.3D Summary: Ag436 The expression of this gene was highest in testis and one breast cancer cell line.  
      Panel 2D Summary: Ag436 The expression of this gene in panel 2D was restricted to one bladder cancer, one kidney cancer and one breast cancer. The expression detected in breast cancer was also in agreement with the results observed for panel 1.3D.  
      Thus, therapeutic modulation of this gene or its protein product is useful in the treatment breast, bladder or kidney cancer.  
      Panel 3D Summary: Ag436 Expression of this gene in panel 3D was restricted to one sample of a plasmacytoma cell line and two lung cancer cell lines. Thus, therapeutic modulation of this gene or gene product is useful in the treatment of plasmacytoma or lung cancer.  
      Panel 4D Summary: Ag436 This gene was expressed in the kidney and in the KU-812 basophil cell line. Basophils are found in the kidney and may give rise to the signal observed in this tissue (Maekawa, K. FEBS Lett 1994 January 10;337(2):200-6). Therefore, therapeutics targeting this gene or its protein product are useful for the detection of basophils in a variety of tissues.  
      U. CG52988-04 and CG52988-06 and CG52988-07: GAGE  
      Expression of full-length physical clones CG52988-04, CG52988-06, and CG52988-07 was assessed using the primer-probe sets Ag437 and Ag7222, described in Tables UA and UB. Results of the RTQ-PCR runs are shown in Tables UC and UD.  
               TABLE UA                          Probe Name Ag437                                 Primers   Sequences   Length   Start Position   SEQ ID No                                             Forward   5′-tcttcccagccagttggatct-3′   21   260   1345                   Probe   TET-5′-tcctcagtgggctcctggacaatca-3′-TAMRA   25   234   1346               Reverse   5′-cagttggtggttcctcttcttga-3′   23   205   1347                  
 
     
       
         
           
               
             
               
                 TABLE UB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag7222 
               
            
           
           
               
               
               
               
               
            
               
                 Primers 
                 Sequences 
                 Length 
                 Start Position 
                 SEQ ID No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-ttgcacctagtggggagatc-3′ 
                 20 
                 173 
                 1348 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-acctgccgttcaagggcctgac-3′-TAMRA 
                 22 
                 137 
                 1349 
               
               
                   
               
               
                 Reverse 
                 5′-cagagccagttcctgttgaa-3′ 
                 20 
                 107 
                 1350 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE UC 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.7 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 1.4 
               
               
                   
                 HUVEC 
                 0.3 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.8 
               
               
                   
                 Melanoma (met) SK-MEL-5 
                 0.0 
               
               
                   
                 Testis 
                 98.6 
               
               
                   
                 Prostate ca. (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate ca. DU145 
                 0.3 
               
               
                   
                 Prostate pool 
                 0.0 
               
               
                   
                 Uterus pool 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.3 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.2 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 1.5 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.7 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 2.1 
               
               
                   
                 Ovary 
                 0.9 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 6.4 
               
               
                   
                 Breast ca. BT-549 
                 0.3 
               
               
                   
                 Breast ca. T47D 
                 0.1 
               
               
                   
                 Breast pool 
                 0.0 
               
               
                   
                 Trachea 
                 2.6 
               
               
                   
                 Lung 
                 1.6 
               
               
                   
                 Fetal Lung 
                 2.5 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 100.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.7 
               
               
                   
                 Lung ca. NCI-H23 
                 2.4 
               
               
                   
                 Lung ca. NCI-H460 
                 1.2 
               
               
                   
                 Lung ca. HOP-62 
                 2.0 
               
               
                   
                 Lung ca. NCI-H522 
                 0.6 
               
               
                   
                 Lung ca. DMS-114 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 5.1 
               
               
                   
                 Kidney pool 
                 1.1 
               
               
                   
                 Fetal Kidney 
                 0.9 
               
               
                   
                 Renal ca. 786-0 
                 0.5 
               
               
                   
                 Renal ca. A498 
                 0.5 
               
               
                   
                 Renal ca. ACHN 
                 0.6 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.3 
               
               
                   
                 Bladder 
                 1.9 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.0 
               
               
                   
                 Stomach 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 0.3 
               
               
                   
                 Colon ca. SW480 
                 0.6 
               
               
                   
                 Colon ca. (SW480 met) SW620 
                 2.4 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 2.1 
               
               
                   
                 Colon cancer tissue 
                 0.0 
               
               
                   
                 Colon ca. SW1116 
                 0.8 
               
               
                   
                 Colon ca. Colo-205 
                 0.6 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon 
                 0.9 
               
               
                   
                 Small Intestine 
                 0.3 
               
               
                   
                 Fetal Heart 
                 0.3 
               
               
                   
                 Heart 
                 0.0 
               
               
                   
                 Lymph Node pool 1 
                 0.0 
               
               
                   
                 Lymph Node pool 2 
                 2.9 
               
               
                   
                 Fetal Skeletal Muscle 
                 1.1 
               
               
                   
                 Skeletal Muscle pool 
                 0.2 
               
               
                   
                 Skeletal Muscle 
                 0.3 
               
               
                   
                 Spleen 
                 1.6 
               
               
                   
                 Thymus 
                 0.9 
               
               
                   
                 CNS cancer (glio/astro) SF-268 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) T98G 
                 0.0 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 1.3 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 0.3 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.9 
               
               
                   
                 CNS cancer (glio) SF-295 
                 6.8 
               
               
                   
                 Brain (Amygdala) 
                 0.3 
               
               
                   
                 Brain (Cerebellum) 
                 1.2 
               
               
                   
                 Brain (Fetal) 
                 1.0 
               
               
                   
                 Brain (Hippocampus) 
                 0.3 
               
               
                   
                 Cerebral Cortex pool 
                 0.5 
               
               
                   
                 Brain (Substantia nigra) 
                 0.0 
               
               
                   
                 Brain (Thalamus) 
                 0.2 
               
               
                   
                 Brain (Whole) 
                 2.1 
               
               
                   
                 Spinal Cord 
                 0.4 
               
               
                   
                 Adrenal Gland 
                 0.4 
               
               
                   
                 Pituitary Gland 
                 0.2 
               
               
                   
                 Salivary Gland 
                 0.0 
               
               
                   
                 Thyroid 
                 0.9 
               
               
                   
                 Pancreatic ca. PANC-1 
                 0.0 
               
               
                   
                 Pancreas pool 
                 0.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag7222, Run 318040952    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE UD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 21.9 
               
               
                   
                 Secondary Th2 act 
                 23.5 
               
               
                   
                 Secondary Tr1 act 
                 17.3 
               
               
                   
                 Secondary Th1 rest 
                 13.6 
               
               
                   
                 Secondary Th2 rest 
                 7.7 
               
               
                   
                 Secondary Tr1 rest 
                 13.6 
               
               
                   
                 Primary Th1 act 
                 33.2 
               
               
                   
                 Primary Th2 act 
                 19.5 
               
               
                   
                 Primary Tr1 act 
                 15.7 
               
               
                   
                 Primary Th1 rest 
                 43.5 
               
               
                   
                 Primary Th2 rest 
                 22.7 
               
               
                   
                 Primary Tr1 rest 
                 19.9 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 18.8 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 48.6 
               
               
                   
                 CD8 lymphocyte act 
                 69.3 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 30.6 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 42.9 
               
               
                   
                 CD4 lymphocyte none 
                 30.4 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 12.7 
               
               
                   
                 LAK cells rest 
                 9.6 
               
               
                   
                 LAK cells IL-2 
                 20.4 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.8 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 42.3 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 18.2 
               
               
                   
                 LAK cells PMA/ionomycin 
                 19.5 
               
               
                   
                 NK Cells IL-2 rest 
                 17.2 
               
               
                   
                 Two Way MLR 3 day 
                 26.2 
               
               
                   
                 Two Way MLR 5 day 
                 11.3 
               
               
                   
                 Two Way MLR 7 day 
                 5.5 
               
               
                   
                 PBMC rest 
                 18.0 
               
               
                   
                 PBMC PWM 
                 41.5 
               
               
                   
                 PBMC PHA-L 
                 24.3 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 10.2 
               
               
                   
                 B lymphocytes PWM 
                 81.2 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 20.3 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 10.4 
               
               
                   
                 Dendritic cells LPS 
                 6.3 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
               
               
                   
                 Monocytes rest 
                 8.7 
               
               
                   
                 Monocytes LPS 
                 4.4 
               
               
                   
                 Macrophages rest 
                 5.4 
               
               
                   
                 Macrophages LPS 
                 11.3 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 10.4 
               
               
                   
                 HUVEC IL-1beta 
                 5.1 
               
               
                   
                 HUVEC IFN gamma 
                 6.3 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 14.9 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 4.8 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 9.5 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 31.0 
               
               
                   
                 Small airway epithelium none 
                 12.2 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 12.3 
               
               
                   
                 Coronery artery SMC rest 
                 7.0 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 25.2 
               
               
                   
                 Astrocytes rest 
                 0.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 14.8 
               
               
                   
                 KU-812 (Basophil) rest 
                 62.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 100.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 6.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 20.2 
               
               
                   
                 Liver cirrhosis 
                 20.7 
               
               
                   
                 Lupus kidney 
                 15.7 
               
               
                   
                 NCI-H292 none 
                 26.1 
               
               
                   
                 NCI-H292 IL-4 
                 12.2 
               
               
                   
                 NCI-H292 IL-9 
                 6.1 
               
               
                   
                 NCI-H292 IL-13 
                 19.6 
               
               
                   
                 NCI-H292 IFN gamma 
                 15.8 
               
               
                   
                 HPAEC none 
                 5.4 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 0.0 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 12.4 
               
               
                   
                 Lung fibroblast IL-4 
                 17.6 
               
               
                   
                 Lung fibroblast IL-9 
                 23.2 
               
               
                   
                 Lung fibroblast IL-13 
                 14.5 
               
               
                   
                 Lung fibroblast IFN gamma 
                 12.9 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 7.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 26.4 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 2.3 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 11.0 
               
               
                   
                 IBD Colitis 2 
                 12.2 
               
               
                   
                 IBD Crohn&#39;s 
                 16.4 
               
               
                   
                 Colon 
                 18.7 
               
               
                   
                 Lung 
                 12.2 
               
               
                   
                 Thymus 
                 12.3 
               
               
                   
                 Kidney 
                 37.6 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag437, Run 145778415    
               
            
           
         
       
     
      General_screening 13  panel_v1.7 Summary: Ag7222 Highest expression of this gene was seen in the testis and a lung cancer cell line sample (CTs=27). Thus, therapeutics targeting this gene or its protein product are useful in the treatment of male infertility or lung cancer.  
      Panel 4D Summary: Ag437 Highest expression was seen in the basophil cell line, KU-812 (CTs=33). Basophils release histamines and other biological modifiers in reponse to allergens and play an important role in the pathology of asthma and hypersensitivity reactions. Therefore, therapeutics designed against the protein encoded by this gene are useful for the reduction or inhibition of inflammation by blocking basophil function in these diseases. In addition, these cells are a reasonable model for the inflammatory cells that take part in various inflammatory lung and bowel diseases, such as asthma, Crohn&#39;s disease, and ulcerative colitis. Therefore, therapeutics that modulate the function of this gene or gene product are useful for the reduction or elimination of the symptoms of patients suffering from asthma, Crohn&#39;s disease, and ulcerative colitis.  
      V. CG5344903: Butyrophilin Like Receptor  
      Expression of gene CG53449-03 was assessed using the primer-probe sets Ag2030 and Ag8336, described in Tables VA and VB. Results of the RTQ-PCR runs are shown in Tables VC and VD.  
               TABLE VA                          Probe Name Ag2030                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-ctgcgtttctgatctgaaaact-3′   22   997   1351                   Probe   TET-5′-acccatagaaaagctccccaggaggt-3′-   26   1022   1352           TAMRA               Reverse   5′-ccaccacactcttccttgtaaa-3′   22   1067   1353                  
 
     
       
         
           
               
             
               
                 TABLE VB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag8336 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-cattgttggactgaagattttctt-3′ 
                 24 
                 844 
                 1354 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ctccaaattccagtggaaaatccagg-3′- 
                 26 
                 868 
                 1355 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-cctgtccgtgctttcttctc-3′ 
                 20 
                 907 
                 1356 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE VC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 0.0 
               
               
                   
                 Pancreas 
                 3.3 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
               
               
                   
                 Adrenal gland 
                 0.0 
               
               
                   
                 Thyroid 
                 3.8 
               
               
                   
                 Salivary gland 
                 0.3 
               
               
                   
                 Pituitary gland 
                 0.0 
               
               
                   
                 Brain (fetal) 
                 0.0 
               
               
                   
                 Brain (whole) 
                 0.0 
               
               
                   
                 Brain (amygdala) 
                 0.3 
               
               
                   
                 Brain (cerebellum) 
                 0.0 
               
               
                   
                 Brain (hippocampus) 
                 0.0 
               
               
                   
                 Brain (substantia nigra) 
                 0.0 
               
               
                   
                 Brain (thalamus) 
                 0.3 
               
               
                   
                 Cerebral Cortex 
                 0.0 
               
               
                   
                 Spinal cord 
                 3.2 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.0 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.0 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 0.0 
               
               
                   
                 glioma SNB-19 
                 0.0 
               
               
                   
                 glioma U251 
                 0.0 
               
               
                   
                 glioma SF-295 
                 0.9 
               
               
                   
                 Heart (fetal) 
                 0.0 
               
               
                   
                 Heart 
                 0.0 
               
               
                   
                 Skeletal muscle (fetal) 
                 0.0 
               
               
                   
                 Skeletal muscle 
                 0.0 
               
               
                   
                 Bone marrow 
                 30.6 
               
               
                   
                 Thymus 
                 0.0 
               
               
                   
                 Spleen 
                 3.0 
               
               
                   
                 Lymph node 
                 4.3 
               
               
                   
                 Colorectal 
                 73.7 
               
               
                   
                 Stomach 
                 15.7 
               
               
                   
                 Small intestine 
                 100.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 40.1 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 1.9 
               
               
                   
                 Colon ca. HCC-2998 
                 8.1 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.0 
               
               
                   
                 Bladder 
                 10.7 
               
               
                   
                 Trachea 
                 1.6 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                 Kidney (fetal) 
                 6.5 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Liver (fetal) 
                 1.6 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
               
               
                   
                 Lung 
                 27.9 
               
               
                   
                 Lung (fetal) 
                 12.4 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.4 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 7.6 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 1.2 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
               
               
                   
                 Mammary gland 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Ovary 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 1.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.0 
               
               
                   
                 Uterus 
                 0.8 
               
               
                   
                 Placenta 
                 0.0 
               
               
                   
                 Prostate 
                 0.0 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 0.0 
               
               
                   
                 Testis 
                 15.8 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
               
               
                   
                 Melanoma M14 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
               
               
                   
                 Adipose 
                 1.8 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2030, Run 165618974    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE VD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Secondary Th1 act 
                 2.3 
                 0.0 
               
               
                 Secondary Th2 act 
                 0.8 
                 0.0 
               
               
                 Secondary Tr1 act 
                 0.0 
                 0.0 
               
               
                 Secondary Th1 rest 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 rest 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 rest 
                 0.0 
                 0.0 
               
               
                 Primary Th1 act 
                 0.0 
                 0.0 
               
               
                 Primary Th2 act 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 act 
                 1.7 
                 0.0 
               
               
                 Primary Th1 rest 
                 0.0 
                 0.0 
               
               
                 Primary Th2 rest 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 rest 
                 0.0 
                 0.0 
               
               
                 CD45RA CD4 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD45RO CD4 lymphocyte act 
                 2.3 
                 3.6 
               
               
                 CD8 lymphocyte act 
                 1.2 
                 0.0 
               
               
                 Secondary CD8 lymphocyte rest 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte act 
                 1.4 
                 0.0 
               
               
                 CD4 lymphocyte none 
                 0.0 
                 0.0 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
                 0.0 
               
               
                 LAK cells rest 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-12 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IFN gamma 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-18 
                 0.0 
                 0.0 
               
               
                 LAK cells PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                 NK Cells IL-2 rest 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 3 day 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 5 day 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 7 day 
                 0.0 
                 0.0 
               
               
                 PBMC rest 
                 0.0 
                 0.0 
               
               
                 PBMC PWM 
                 1.1 
                 0.0 
               
               
                 PBMC PHA-L 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) none 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
               
               
                 B lymphocytes PWM 
                 4.7 
                 0.0 
               
               
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                 Dendritic cells none 
                 0.0 
                 0.0 
               
               
                 Dendritic cells LPS 
                 0.0 
                 0.0 
               
               
                 Dendritic cells anti-CD40 
                 0.0 
                 0.0 
               
               
                 Monocytes rest 
                 0.0 
                 0.0 
               
               
                 Monocytes LPS 
                 0.0 
                 0.0 
               
               
                 Macrophages rest 
                 0.0 
                 0.0 
               
               
                 Macrophages LPS 
                 0.0 
                 0.0 
               
               
                 HUVEC none 
                 0.0 
                 0.0 
               
               
                 HUVEC starved 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-1beta 
                 0.0 
                 0.0 
               
               
                 HUVEC IFN gamma 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IL4 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-11 
                 0.0 
                 0.0 
               
               
                 Lung Microvascular EC none 
                 0.0 
                 0.0 
               
               
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Microvascular Dermal EC none 
                 0.0 
                 0.0 
               
               
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
                 0.0 
               
               
                 Small airway epithelium none 
                 0.0 
                 0.0 
               
               
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Coronery artery SMC rest 
                 0.0 
                 0.0 
               
               
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Astrocytes rest 
                 0.0 
                 0.0 
               
               
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) rest 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) none 
                 0.0 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Liver cirrhosis 
                 12.9 
                 1.3 
               
               
                 NCI-H292 none 
                 0.0 
                 3.7 
               
               
                 NCI-H292 IL-4 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IL-9 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IL-13 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IFN gamma 
                 0.0 
                 0.0 
               
               
                 HPAEC none 
                 0.0 
                 0.0 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast none 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-4 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-9 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-13 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 rest 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.7 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast IL-4 
                 0.0 
                 0.0 
               
               
                 Dermal Fibroblasts rest 
                 0.0 
                 0.0 
               
               
                 Neutrophils TNFa + LPS 
                 23.2 
                 11.6 
               
               
                 Neutrophils rest 
                 84.1 
                 100.0 
               
               
                 Colon 
                 100.0 
                 5.7 
               
               
                 Lung 
                 2.4 
                 0.0 
               
               
                 Thymus 
                 0.0 
                 0.0 
               
               
                 Kidney 
                 0.8 
                 0.0 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag2030, Run 306413257    
               
               
                   Column B - Rel. Exp. (%) Ag8336, Run 343540037    
               
            
           
         
       
     
      Panel 1.3D Summary: Ag2030 This gene was most prominently expressed in gastrointestinal tissues. Expression of this gene was highest in colon and small intestine (CT=31) and was also significantly expressed in stomach tissue. Therapeutic modulation of this gene or its protein product is useful as a marker of gastrointestinal tissue, and specifically of small intestine, stomach or colorectal tissue.  
      Panel 4.1D Summary: Ag2030/Ag8336 Expression of this gene was limited to colon and neutrophils (CTs=30-34). Expression of this gene was down-regulated in activated neutrophils. This expression profile demonstrated that the encoded protein reduces activation of these inflammatory cells and is useful as a protein therapeutic to eliminate the symptoms in patients with Crohn&#39;s disease, ulcerative colitis, multiple sclerosis, chronic obstructive pulmonary disease, asthma, emphysema, rheumatoid arthritis, lupus erythematosus, or psoriasis. In addition, small molecule or antibodies targeting this gene or gene product are effective in increasing the immune response in patients with AIDS or other immunodeficiencies.  
      W. CG53449-04: B7/Butyrophilin Like Receptor  
      Expression of gene CG53449-04 was assessed using the primer-probe sets Ag2030, Ag6640 and Ag7598, described in Tables WA, WB and WC. Results of the RTQ-PCR runs are shown in Tables WD, WE, WF, WG, WH and WI.  
               TABLE WA                          Probe Name Ag2030                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-ctgcgtttctgatctgaaaact-3′   22   1185   1357                   Probe   TET-5′-acccatagaaaagctccccaggaggt-3′-   26   1210   1358           TAMRA               Reverse   5′-ccaccacactcttccttgtaaa-3′   22   1255   1359                  
 
     
       
         
           
               
             
               
                 TABLE WB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag6640 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-gtgtaagcgagagagagaagcat-3′ 
                 23 
                 938 
                 1360 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-atctctgatcctgtccctgctggaac-3′- 
                 26 
                 981 
                 1361 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-tagaagaagagaagcagctggat-3′ 
                 23 
                 1015 
                 1362 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE WC 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag7598 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-tgctcccacatccagct-3′ 
                 17 
                 1006 
                 1363 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ttcttctagtcctagcctccagggg-3′- 
                 25 
                 1030 
                 1364 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-gctttcttctccagtccagttc-3′ 
                 22 
                 1084 
                 1365 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE WD 
               
             
            
               
                   
               
               
                   
               
               
                 AI_comprehensive panel_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 110967 COPD-F 
                 13.5 
               
               
                   
                 110980 COPD-F 
                 25.5 
               
               
                   
                 110968 COPD-M 
                 15.1 
               
               
                   
                 110977 COPD-M 
                 42.0 
               
               
                   
                 110989 Emphysema-F 
                 6.3 
               
               
                   
                 110992 Emphysema-F 
                 0.0 
               
               
                   
                 110993 Emphysema-F 
                 6.7 
               
               
                   
                 110994 Emphysema-F 
                 2.0 
               
               
                   
                 110995 Emphysema-F 
                 1.0 
               
               
                   
                 110996 Emphysema-F 
                 0.0 
               
               
                   
                 110997 Asthma-M 
                 1.6 
               
               
                   
                 111001 Asthma-F 
                 6.0 
               
               
                   
                 111002 Asthma-F 
                 4.0 
               
               
                   
                 111003 Atopic Asthma-F 
                 3.5 
               
               
                   
                 111004 Atopic Asthma-F 
                 3.4 
               
               
                   
                 111005 Atopic Asthma-F 
                 4.5 
               
               
                   
                 111006 Atopic Asthma-F 
                 0.0 
               
               
                   
                 111417 Allergy-M 
                 4.5 
               
               
                   
                 112347 Allergy-M 
                 0.4 
               
               
                   
                 112349 Normal Lung-F 
                 0.4 
               
               
                   
                 112357 Normal Lung-F 
                 8.9 
               
               
                   
                 112354 Normal Lung-M 
                 4.8 
               
               
                   
                 112374 Crohns-F 
                 4.2 
               
               
                   
                 112389 Match Control Crohns-F 
                 7.2 
               
               
                   
                 112375 Crohns-F 
                 1.9 
               
               
                   
                 112732 Match Control Crohns-F 
                 3.9 
               
               
                   
                 112725 Crohns-M 
                 3.5 
               
               
                   
                 112387 Match Control Crohns-M 
                 0.3 
               
               
                   
                 112378 Crohns-M 
                 1.2 
               
               
                   
                 112390 Match Control Crohns-M 
                 24.5 
               
               
                   
                 112726 Crohns-M 
                 2.0 
               
               
                   
                 112731 Match Control Crohns-M 
                 4.5 
               
               
                   
                 112380 Ulcer Col-F 
                 7.2 
               
               
                   
                 112734 Match Control Ulcer Col-F 
                 15.7 
               
               
                   
                 112384 Ulcer Col-F 
                 13.1 
               
               
                   
                 112737 Match Control Ulcer Col-F 
                 3.1 
               
               
                   
                 112386 Ulcer Col-F 
                 5.6 
               
               
                   
                 112738 Match Control Ulcer Col-F 
                 19.9 
               
               
                   
                 112381 Ulcer Col-M 
                 0.3 
               
               
                   
                 112735 Match Control Ulcer Col-M 
                 0.0 
               
               
                   
                 112382 Ulcer Col-M 
                 18.7 
               
               
                   
                 112394 Match Control Ulcer Col-M 
                 3.4 
               
               
                   
                 112383 Ulcer Col-M 
                 2.6 
               
               
                   
                 112736 Match Control Ulcer Col-M 
                 6.2 
               
               
                   
                 112423 Psoriasis-F 
                 12.3 
               
               
                   
                 112427 Match Control Psoriasis-F 
                 25.2 
               
               
                   
                 112418 Psoriasis-M 
                 26.8 
               
               
                   
                 112723 Match Control Psoriasis-M 
                 2.9 
               
               
                   
                 112419 Psoriasis-M 
                 18.3 
               
               
                   
                 112424 Match Control Psoriasis-M 
                 11.7 
               
               
                   
                 112420 Psoriasis-M 
                 32.8 
               
               
                   
                 112425 Match Control Psoriasis-M 
                 14.2 
               
               
                   
                 104689 (MF) OA Bone-Backus 
                 24.5 
               
               
                   
                 104690 (MF) Adj “Normal” Bone-Backus 
                 38.4 
               
               
                   
                 104691 (MF) OA Synovium-Backus 
                 6.4 
               
               
                   
                 104692 (BA) OA Cartilage-Backus 
                 0.0 
               
               
                   
                 104694 (BA) OA Bone-Backus 
                 6.0 
               
               
                   
                 104695 (BA) Adj “Normal” Bone-Backus 
                 37.4 
               
               
                   
                 104696 (BA) OA Synovium-Backus 
                 3.4 
               
               
                   
                 104700 (SS) OA Bone-Backus 
                 88.3 
               
               
                   
                 104701 (SS) Adj “Normal” Bone-Backus 
                 30.4 
               
               
                   
                 104702 (SS) OA Synovium-Backus 
                 28.3 
               
               
                   
                 117093 OA Cartilage Rep7 
                 15.2 
               
               
                   
                 112672 OA Bone5 
                 13.4 
               
               
                   
                 112673 OA Synovium5 
                 7.5 
               
               
                   
                 112674 OA Synovial Fluid cells5 
                 6.0 
               
               
                   
                 117100 OA Cartilage Rep14 
                 4.5 
               
               
                   
                 112756 OA Bone9 
                 14.2 
               
               
                   
                 112757 OA Synovium9 
                 24.1 
               
               
                   
                 112758 OA Synovial Fluid Cells9 
                 37.9 
               
               
                   
                 117125 RA Cartilage Rep2 
                 10.6 
               
               
                   
                 113492 Bone2 RA 
                 100.0 
               
               
                   
                 113493 Synovium2 RA 
                 47.0 
               
               
                   
                 113494 Syn Fluid Cells RA 
                 68.3 
               
               
                   
                 113499 Cartilage4 RA 
                 67.8 
               
               
                   
                 113500 Bone4 RA 
                 81.2 
               
               
                   
                 113501 Synovium4 RA 
                 64.2 
               
               
                   
                 113502 Syn Fluid Cells4 RA 
                 51.1 
               
               
                   
                 113495 Cartilage3 RA 
                 68.8 
               
               
                   
                 113496 Bone3 RA 
                 66.9 
               
               
                   
                 113497 Synovium3 RA 
                 52.5 
               
               
                   
                 113498 Syn Fluid Cells3 RA 
                 85.9 
               
               
                   
                 117106 Normal Cartilage Rep20 
                 1.1 
               
               
                   
                 113663 Bone3 Normal 
                 0.0 
               
               
                   
                 113664 Synovium3 Normal 
                 0.0 
               
               
                   
                 113665 Syn Fluid Cells3 Normal 
                 0.0 
               
               
                   
                 117107 Normal Cartilage Rep22 
                 7.9 
               
               
                   
                 113667 Bone4 Normal 
                 5.1 
               
               
                   
                 113668 Synovium4 Normal 
                 3.4 
               
               
                   
                 113669 Syn Fluid Cells4 Normal 
                 3.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag6640, Run 296559279    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE WE 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.6 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 11.0 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma* M14 
                 0.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.0 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.0 
               
               
                   
                 Testis Pool 
                 16.5 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.1 
               
               
                   
                 Prostate Pool 
                 1.4 
               
               
                   
                 Placenta 
                 0.9 
               
               
                   
                 Uterus Pool 
                 0.3 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.2 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 3.8 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
               
               
                   
                 Ovary 
                 2.9 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca. BT 549 
                 0.0 
               
               
                   
                 Breast ca. T47D 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Breast Pool 
                 2.5 
               
               
                   
                 Trachea 
                 1.2 
               
               
                   
                 Lung 
                 0.1 
               
               
                   
                 Fetal Lung 
                 17.8 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 14.9 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.2 
               
               
                   
                 Lung ca. A549 
                 1.3 
               
               
                   
                 Lung ca. NCI-H526 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 1.1 
               
               
                   
                 Lung ca. NCI-H460 
                 1.1 
               
               
                   
                 Lung ca. HOP-62 
                 0.0 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 1.3 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
               
               
                   
                 Kidney Pool 
                 5.6 
               
               
                   
                 Fetal Kidney 
                 10.3 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Bladder 
                 13.0 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.3 
               
               
                   
                 Gastric ca. KATO III 
                 0.6 
               
               
                   
                 Colon ca. SW-948 
                 1.4 
               
               
                   
                 Colon ca. SW480 
                 0.8 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.1 
               
               
                   
                 Colon ca. HT29 
                 0.4 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 100.0 
               
               
                   
                 Colon cancer tissue 
                 9.3 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 7.0 
               
               
                   
                 Colon ca. SW-48 
                 26.2 
               
               
                   
                 Colon Pool 
                 1.3 
               
               
                   
                 Small Intestine Pool 
                 2.3 
               
               
                   
                 Stomach Pool 
                 1.6 
               
               
                   
                 Bone Marrow Pool 
                 0.6 
               
               
                   
                 Fetal Heart 
                 2.1 
               
               
                   
                 Heart Pool 
                 2.1 
               
               
                   
                 Lymph Node Pool 
                 2.1 
               
               
                   
                 Fetal Skeletal Muscle 
                 4.5 
               
               
                   
                 Skeletal Muscle Pool 
                 0.0 
               
               
                   
                 Spleen Pool 
                 8.2 
               
               
                   
                 Thymus Pool 
                 1.7 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 8.4 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.0 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 0.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.3 
               
               
                   
                 Brain (Amygdala) Pool 
                 0.0 
               
               
                   
                 Brain (cerebellum) 
                 0.4 
               
               
                   
                 Brain (fetal) 
                 0.3 
               
               
                   
                 Brain (Hippocampus) Pool 
                 0.8 
               
               
                   
                 Cerebral Cortex Pool 
                 3.8 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 0.0 
               
               
                   
                 Brain (Thalamus) Pool 
                 0.0 
               
               
                   
                 Brain (whole) 
                 1.0 
               
               
                   
                 Spinal Cord Pool 
                 0.4 
               
               
                   
                 Adrenal Gland 
                 1.6 
               
               
                   
                 Pituitary gland Pool 
                 0.0 
               
               
                   
                 Salivary Gland 
                 0.7 
               
               
                   
                 Thyroid (female) 
                 0.3 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.0 
               
               
                   
                 Pancreas Pool 
                 6.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag6640, Run 277241469    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE WF 
               
             
            
               
                   
               
               
                   
               
               
                 PGI1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 162191_Normal Lung 1 (IBS) 
                 4.6 
               
               
                   
                 162570_Normal Lung 4 (Aastrand) 
                 2.0 
               
               
                   
                 160468_MD lung 
                 2.9 
               
               
                   
                 156629_MD Lung 13 
                 1.6 
               
               
                   
                 162571 _Normal Lung 3 (Aastrand) 
                 0.7 
               
               
                   
                 162186_Fibrosis Lung 1 (Genomic 
                 26.4 
               
               
                   
                 Collaborative) 
               
               
                   
                 162187_Fibrosis Lung 2 (Genomic 
                 31.6 
               
               
                   
                 Collaborative) 
               
               
                   
                 151281_Fibrosis lung 11(Ardais) 
                 45.1 
               
               
                   
                 162190_Asthma Lung 4 (Genomic 
                 45.7 
               
               
                   
                 Collaborative) 
               
               
                   
                 160467_Asthma Lung 13 (MD) 
                 2.1 
               
               
                   
                 137027_Emphysema Lung 1 (Ardais) 
                 6.0 
               
               
                   
                 137028_Emphysema Lung 2 (Ardais) 
                 5.7 
               
               
                   
                 137040_Emphysema Lung 3 (Ardais) 
                 7.0 
               
               
                   
                 137041_Emphysema Lung 4 (Ardais) 
                 14.1 
               
               
                   
                 137043_Emphysema Lung 5 (Ardais) 
                 7.5 
               
               
                   
                 142817_Emphysema Lung 6 (Ardais) 
                 20.4 
               
               
                   
                 142818_Emphysema Lung 7 (Ardais) 
                 19.3 
               
               
                   
                 142819_Emphysema Lung 8 (Ardais) 
                 10.4 
               
               
                   
                 142820_Emphysema Lung 9 (Ardais) 
                 1.8 
               
               
                   
                 142821_Emphysema Lung 10 (Ardais) 
                 12.6 
               
               
                   
                 162185_Emphysema Lung 12 (Ardais) 
                 13.9 
               
               
                   
                 162184_Emphysema Lung 13 (Ardais) 
                 5.3 
               
               
                   
                 162183_Emphysema Lung 14 (Ardais) 
                 28.5 
               
               
                   
                 162188_Emphysema Lung 15 (Genomic 
                 20.2 
               
               
                   
                 Collaborative) 
               
               
                   
                 162177_NAT UC Colon 1(Ardais) 
                 100.0 
               
               
                   
                 162176_UC Colon 1(Ardais) 
                 59.9 
               
               
                   
                 162179_NAT UC Colon 2(Ardais) 
                 65.5 
               
               
                   
                 162178_UC Colon 2(Ardais) 
                 8.1 
               
               
                   
                 162181_NAT UC Colon 3(Ardais) 
                 63.7 
               
               
                   
                 162180_UC Colon 3(Ardais) 
                 5.2 
               
               
                   
                 162182_NAT UC Colon 4 (Ardais) 
                 100.0 
               
               
                   
                 137042_UC Colon 1108 
                 4.2 
               
               
                   
                 137029_UC Colon 8215 
                 8.1 
               
               
                   
                 137031_UC Colon 8217 
                 5.6 
               
               
                   
                 137036_UC Colon 1137 
                 22.2 
               
               
                   
                 137038_UC Colon 1491 
                 13.4 
               
               
                   
                 137039_UC Colon 1546 
                 27.0 
               
               
                   
                 162594_NAT Crohn&#39;s 47751 (NDRI) 
                 3.7 
               
               
                   
                 162593_Crohn&#39;s 47751 (NDRI) 
                 0.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag6640, Run 376378448    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE WG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 0.0 
               
               
                   
                 Pancreas 
                 3.3 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
               
               
                   
                 Adrenal gland 
                 0.0 
               
               
                   
                 Thyroid 
                 3.8 
               
               
                   
                 Salivary gland 
                 0.3 
               
               
                   
                 Pituitary gland 
                 0.0 
               
               
                   
                 Brain (fetal) 
                 0.0 
               
               
                   
                 Brain (whole) 
                 0.0 
               
               
                   
                 Brain (amygdala) 
                 0.3 
               
               
                   
                 Brain (cerebellum) 
                 0.0 
               
               
                   
                 Brain (hippocampus) 
                 0.0 
               
               
                   
                 Brain (substantia nigra) 
                 0.0 
               
               
                   
                 Brain (thalamus) 
                 0.3 
               
               
                   
                 Cerebral Cortex 
                 0.0 
               
               
                   
                 Spinal cord 
                 3.2 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.0 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.0 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 0.0 
               
               
                   
                 glioma SNB-19 
                 0.0 
               
               
                   
                 glioma U251 
                 0.0 
               
               
                   
                 glioma SF-295 
                 0.9 
               
               
                   
                 Heart (fetal) 
                 0.0 
               
               
                   
                 Heart 
                 0.0 
               
               
                   
                 Skeletal muscle (fetal) 
                 0.0 
               
               
                   
                 Skeletal muscle 
                 0.0 
               
               
                   
                 Bone marrow 
                 30.6 
               
               
                   
                 Thymus 
                 0.0 
               
               
                   
                 Spleen 
                 3.0 
               
               
                   
                 Lymph node 
                 4.3 
               
               
                   
                 Colorectal 
                 73.7 
               
               
                   
                 Stomach 
                 15.7 
               
               
                   
                 Small intestine 
                 100.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 40.1 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 1.9 
               
               
                   
                 Colon ca. HCC-2998 
                 8.1 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.0 
               
               
                   
                 Bladder 
                 10.7 
               
               
                   
                 Trachea 
                 1.6 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                 Kidney (fetal) 
                 6.5 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Liver (fetal) 
                 1.6 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
               
               
                   
                 Lung 
                 27.9 
               
               
                   
                 Lung (fetal) 
                 12.4 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.4 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 7.6 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 1.2 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
               
               
                   
                 Mammary gland 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Ovary 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 1.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.0 
               
               
                   
                 Uterus 
                 0.8 
               
               
                   
                 Placenta 
                 0.0 
               
               
                   
                 Prostate 
                 0.0 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 0.0 
               
               
                   
                 Testis 
                 15.8 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
               
               
                   
                 Melanoma M14 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
               
               
                   
                 Adipose 
                 1.8 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2030, Run 165618974    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE WH 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
                 D 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Secondary Th1 act 
                 2.3 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 act 
                 0.8 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 act 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Th1 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th1 act 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th2 act 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 act 
                 1.7 
                 0.0 
                 0.0 
                 1.6 
               
               
                 Primary Th1 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th2 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CD45RA CD4 lymphocyte act 
                 0.0 
                 0.9 
                 0.0 
                 0.0 
               
               
                 CD45RO CD4 lymphocyte act 
                 2.3 
                 3.0 
                 4.0 
                 9.5 
               
               
                 CD8 lymphocyte act 
                 1.2 
                 0.0 
                 0.7 
                 0.0 
               
               
                 Secondary CD8 lymphocyte rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte act 
                 1.4 
                 0.7 
                 0.0 
                 0.0 
               
               
                 CD4 lymphocyte none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
                 0.0 
                 0.9 
                 0.0 
               
               
                 LAK cells rest 
                 0.0 
                 0.0 
                 1.5 
                 0.0 
               
               
                 LAK cells IL-2 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-12 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IFN gamma 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-18 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 NK Cells IL-2 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 3 day 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 5 day 
                 0.0 
                 0.0 
                 1.1 
                 0.0 
               
               
                 Two Way MLR 7 day 
                 0.0 
                 1.5 
                 0.0 
                 0.0 
               
               
                 PBMC rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 PBMC PWM 
                 1.1 
                 0.0 
                 0.5 
                 0.0 
               
               
                 PBMC PHA-L 
                 0.0 
                 0.0 
                 0.5 
                 0.0 
               
               
                 Ramos (B cell) none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 B lymphocytes PWM 
                 4.7 
                 2.8 
                 2.7 
                 1.5 
               
               
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 2.3 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells LPS 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells anti-CD40 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Monocytes rest 
                 0.0 
                 0.0 
                 0.3 
                 0.0 
               
               
                 Monocytes LPS 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Macrophages rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Macrophages LPS 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC starved 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-1 beta 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC IFN gamma 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IL4 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-11 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung Microvascular EC none 
                 0.0 
                 0.0 
                 0.0 
                 1.7 
               
               
                 Lung Microvascular EC 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 TNFalpha + IL-1beta 
               
               
                 Microvascular Dermal EC none 
                 0.0 
                 0.0 
                 1.1 
                 0.0 
               
               
                 Microsvasular Dermal EC 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 TNFalpha + IL-1beta 
               
               
                 Bronchial epithelium 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 TNFalpha + IL1beta 
               
               
                 Small airway epithelium none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Small airway epithelium 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 TNFalpha + IL-1beta 
               
               
                 Coronery artery SMC rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Coronery artery SMC 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 TNFalpha + IL-1beta 
               
               
                 Astrocytes rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) rest 
                 0.0 
                 0.0 
                 0.9 
                 0.0 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 TNFalpha + IL-1beta 
               
               
                 Liver cirrhosis 
                 12.9 
                 2.8 
                 6.0 
                 0.0 
               
               
                 NCI-H292 none 
                 0.0 
                 2.4 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IL-4 
                 0.0 
                 2.4 
                 0.0 
                 1.7 
               
               
                 NCI-H292 IL-9 
                 0.0 
                 1.1 
                 3.7 
                 1.3 
               
               
                 NCI-H292 IL-13 
                 0.0 
                 0.0 
                 1.6 
                 1.6 
               
               
                 NCI-H292 IFN gamma 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HPAEC none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-4 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-9 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-13 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IFN gamma 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.7 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast IFN gamma 
                 0.0 
                 0.0 
                 1.1 
                 0.0 
               
               
                 Dermal fibroblast IL-4 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dermal Fibroblasts rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Neutrophils TNFa + LPS 
                 23.2 
                 31.0 
                 20.6 
                 38.4 
               
               
                 Neutrophils rest 
                 84.1 
                 100.0 
                 100.0 
                 100.0 
               
               
                 Colon 
                 100.0 
                 23.8 
                 25.5 
                 40.3 
               
               
                 Lung 
                 2.4 
                 0.0 
                 0.7 
                 0.0 
               
               
                 Thymus 
                 0.0 
                 0.8 
                 0.0 
                 0.0 
               
               
                 Kidney 
                 0.8 
                 3.0 
                 1.3 
                 0.0 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag2030, Run 306413257    
               
               
                   Column B - Rel. Exp. (%) Ag6640, Run 274991372    
               
               
                   Column C - Rel. Exp. (%) Ag6640, Run 296907633    
               
               
                   Column D - Rel. Exp. (%) Ag7598, Run 310594484    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE WI 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.1 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.1 
               
               
                   
                 Primary Tr1 act 
                 0.1 
               
               
                   
                 Primary Th1 rest 
                 0.1 
               
               
                   
                 Primary Th2 rest 
                 0.1 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.1 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.2 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.1 
               
               
                   
                 LAK cells rest 
                 0.1 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.1 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.3 
               
               
                   
                 PBMC PHA-L 
                 0.1 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.1 
               
               
                   
                 B lymphocytes PWM 
                 2.5 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.1 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.0 
               
               
                   
                 HUVEC IL-1 beta 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.1 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.1 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
               
               
                   
                 Small airway epithelium none 
                 0.0 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Coronery artery SMC rest 
                 0.0 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Astrocytes rest 
                 0.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Liver cirrhosis 
                 0.6 
               
               
                   
                 Lupus kidney 
                 0.0 
               
               
                   
                 NCI-H292 none 
                 0.1 
               
               
                   
                 NCI-H292 IL-4 
                 0.0 
               
               
                   
                 NCI-H292 IL-9 
                 0.0 
               
               
                   
                 NCI-H292 IL-13 
                 0.0 
               
               
                   
                 NCI-H292 IFN gamma 
                 0.0 
               
               
                   
                 HPAEC none 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 0.0 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast IL-4 
                 0.0 
               
               
                   
                 Lung fibroblast IL-9 
                 0.0 
               
               
                   
                 Lung fibroblast IL-13 
                 0.0 
               
               
                   
                 Lung fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.1 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 0.0 
               
               
                   
                 IBD Colitis 2 
                 0.0 
               
               
                   
                 IBD Crohn&#39;s 
                 5.3 
               
               
                   
                 Colon 
                 100.0 
               
               
                   
                 Lung 
                 0.5 
               
               
                   
                 Thymus 
                 0.5 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2030, Run 161379401    
               
            
           
         
       
     
      AI_comprehensive panel_v1.0 Summary: Ag6640 Highest expression of this gene was detected in rheumatoid arthritis bone (CT=31). This gene was expressed at higher levels in rheumatoid arthritis (RA) tissues and osteoarthritis (OA) bone. In addition, significant expression of this gene was also seen in COPD lung, and psoriasis samples. This gene encodes a homolog of butyrophilin like receptor and is a member of the B7 family. B7 family members are costimulatory molecules, which are necessary for optimal activation of T lymphocytes after T cell receptor (TCR) engagement. The most extensively studied costimulatory molecules are B7-1 (CD80) and B7-2 (CD86). Interaction of CD28 on T cells with either B7-1 or B7-2 augments T cell activation and promotes T cell survival (Chambers, C. A. &amp; Allison, J. P., 1997, Curr. Opin. Immunol. 9, 396-404). In contrast, binding of B7-1 or B7-2 with cytotoxic T lymphocyte antigen 4 (CTLA-4), a homolog of CD28, inhibits the T cell response by delivering a putative negative signal. Therapeutic modulation of this gene, expressed protein and/or use of antibodies or small molecule drug targeting the gene or gene product is effective in the treatment of psoriases, osteoarthritis and rheumatoid arthritis.  
      General_screening 13  panel_v1.6 Summary: Significant expression of this gene was seen in colon cancer cell lines, a lung cancer and a brain cancer cell lines. Therefore, expression of this gene is useful as a diagnostic marker and therapeutic modulation of this gene, expressed protein, and/or use of antibodies or small molecule drug targeting this gene or gene product is useful in the treatment of colon, lung and brain cancers.  
      Low expression of this gene was also seen in metabolic tissues including adipose, pancrease, and fetal skeletal muscle. Therefore, modulation of this gene or gene product is useful in the treatment of metabolic disorders such as diabetes and obesity.  
      Low expression of this gene was also seen fetal lung. Expression of this gene was higher in fetal (CTs=32-34) relative to adult lung and skeletal muscle (CTs=40). The relative overexpression of this gene in fetal tissue shows that the protein product enhances lung and skeletal muscle growth or development in the fetus and also acts in a regenerative capacity in the adult. Therapeutic modulation of this gene or the protein encoded by this gene is useful in the treatment of lung and skeletal muscle related diseases.  
      PGI1.0 Summary: Ag6640 Highest expression of this gene was detected in normal adjacent colon tissue from a ulcerative colitis patient (CT=26.4). Significant expression of this gene was also detected in normal adjacent and ulcerative colitis tissue samples. Expression of this gene was higher in normal relative to diseased tissue. Modulation of this gene and/or its expressed protein is useful in the treatment of ulcerative colitis.  
      In addition, high to moderate expression of this gene was also detected in fibrosis, asthma and emphyzema lung. Therapeutic modulation of this gene, expressed protein is useful in the treatment of fibrosis, asthma and emphysema.  
      Panel 1.3D Summary: Ag2030 This gene was most prominently expressed in gastrointestinal tissues. Expression of this gene was highest in colon and small intestine (CT=31) and was also significantly expressed in stomach tissue. Expression of this gene is useful as a marker of gastrointestinal tissue, and specifically of small intestine, stomach or colorectal tissue.  
      Panel 4.1D Summary: Ag2030/Ag6640/Ag7598 Expression of this gene was limited to colon and neutrophils (CTs=30-34). Expression of this gene was down-regulated in activated neutrophils. This expression profile demonstrates that the encoded protein reduces activation of these inflammatory cells and is useful as a protein therapeutic to eliminate the symptoms in patients with Crohn&#39;s disease, ulcerative colitis, multiple sclerosis, chronic obstructive pulmonary disease, asthma, emphysema, rheumatoid arthritis, lupus erythematosus, or psoriasis. In addition, small molecule or antibodies targeting this gene or gene product are effective in increasing the immune response in patients with AIDS or other immunodeficiencies.  
      Panel 4D Summary: Ag2030 The gene expression on this panel was limited essentially to normal colon. These results were consistent with what is observed in Panel 1.3D. This gene was not expressed or was expressed only at low levels in IBD colitis and Crohn&#39;s disease. Therefore, this gene is useful as a marker to distinguish normal colon from diseased colon. This gene encodes a protein with homology to the butyrophilin-like receptor. The butyrophilin-like membrane proteins are similar to the B7 family of co-stimulatory factors. B7 proteins are expressed on many cell types and function in the process of antigen presentation to T lymphocytes in the stimulation of the immune response. Recently identified B7 family members have included inhibitory proteins that reduced the activation of T lymphocytes upon cell-cell interaction. This gene or gene product is useful for the modulation of the functions associated with antigen presentation to T cells. Replacement of this gene product by gene therapy or use of the isolated extracellular domain of the gene protein is of use as a therapeutic in the treatment of IBD colitis and Crohn&#39;s disease.  
      X. CG53908-01: Netrin Receptor Unc5h1  
      Expression of full-length physical clone CG53908-01 was assessed using the primer-probe sets Ag1395 and Ag8392, described in Tables XA and XB. Results of the RTQ-PCR runs are shown in Tables XC, XD, XE, XF, XG, XH, XL XJ, and XK.  
               TABLE XA                          Probe Name Ag1395                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-ctgcacttcaaggacagttacc-3′   22   2184   1366                   Probe   TET-5′-ctatccatccacgatgtgcccagct-3′-   25   2217   1367           TAMRA               Reverse   5′-tgacaaggagcttactcttcca-3′   22   2247   1368                  
 
     
       
         
           
               
             
               
                 TABLE XB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag8392 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-ccctctatgtgggcctcat-3′ 
                 19 
                 1168 
                 1369 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-tgcttgtcctcatcctcgtttattgc-3′- 
                 26 
                 1216 
                 1370 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-tccagcccctccttcttc-3′ 
                 18 
                 1244 
                 1371 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XC 
               
             
            
               
                   
               
               
                   
               
               
                 Ardais Breast1.0 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 97739_Breast cancer (CHTN20676) 
                 0.6 
                 0.2 
               
               
                   
                 105689_Breast cancer 2B 
                 0.0 
                 0.1 
               
               
                   
                 111297_Breast cancer metastasis (9369)* 
                 23.0 
                 17.8 
               
               
                   
                 145848_Breast cancer (9B6) 
                 8.7 
                 6.0 
               
               
                   
                 145859_Breast cancer (9EC) 
                 1.0 
                 0.6 
               
               
                   
                 153632_Breast cancer (D39) 
                 1.0 
                 0.2 
               
               
                   
                 153643_Breast cancer (D44) 
                 6.0 
                 2.6 
               
               
                   
                 164672_Breast cancer (7464) 
                 9.1 
                 4.5 
               
               
                   
                 164681_Breast cancer (5787) 
                 6.8 
                 3.3 
               
               
                   
                 97748_Breast cancer (CHTN20931) 
                 9.3 
                 0.1 
               
               
                   
                 105690_Breast NAT 2A 
                 1.7 
                 0.6 
               
               
                   
                 111302_Breast NAT (6314) 
                 1.8 
                 1.2 
               
               
                   
                 145850_Breast cancer (9C7) 
                 2.8 
                 0.8 
               
               
                   
                 149844_Breast cancer (24178) 
                 3.3 
                 2.6 
               
               
                   
                 153633_Breast cancer (D3A) 
                 72.7 
                 34.4 
               
               
                   
                 153644_Breast cancer (D45) 
                 1.2 
                 0.8 
               
               
                   
                 164673_Breast cancer (8452) 
                 2.9 
                 2.6 
               
               
                   
                 164682_Breast cancer (6342)* 
                 2.1 
                 1.5 
               
               
                   
                 97751_Breast cancer (CHTN21053) 
                 3.5 
                 3.2 
               
               
                   
                 105694_Breast NAT 
                 15.8 
                 10.6 
               
               
                   
                 116417_Breast cancer (3367)* 
                 1.8 
                 1.5 
               
               
                   
                 145852_Breast cancer (A1A) 
                 1.0 
                 0.4 
               
               
                   
                 151097_Breast cancer (CHTN24298) 
                 0.9 
                 0.3 
               
               
                   
                 153634_Breast cancer (D3B) 
                 1.0 
                 0.5 
               
               
                   
                 155797_Breast cancer (EA6) 
                 81.2 
                 67.8 
               
               
                   
                 164674_Breast cancer (8811) 
                 2.8 
                 2.4 
               
               
                   
                 164683_Breast cancer (6470) 
                 100.0 
                 100.0 
               
               
                   
                 97763_Breast cancer (OD06083) 
                 3.7 
                 2.4 
               
               
                   
                 108830_Breast cancer metastasis 
                 1.1 
                 0.4 
               
               
                   
                 (OD06855)* 
               
               
                   
                 116418_Breast cancer (3378)* 
                 2.4 
                 1.7 
               
               
                   
                 145853_Breast cancer (9F3) 
                 1.6 
                 0.7 
               
               
                   
                 153432_Breast cancer (CHTN24652) 
                 15.6 
                 6.2 
               
               
                   
                 153635_Breast cancer (D3C) 
                 0.6 
                 0.4 
               
               
                   
                 164667_Breast cancer (5785) 
                 1.6 
                 12.2 
               
               
                   
                 164676_Breast cancer (5070) 
                 1.5 
                 0.6 
               
               
                   
                 164684_Breast cancer (6509) 
                 8.8 
                 3.5 
               
               
                   
                 97764_Breast cancer node 
                 4.4 
                 4.8 
               
               
                   
                 metastasis (OD06083) 
               
               
                   
                 108847_Breast cancer 
                 2.8 
                 1.2 
               
               
                   
                 116421_Breast cancer (6314) 
                 0.1 
                 0.0 
               
               
                   
                 145854_Breast cancer (9B8) 
                 1.2 
                 0.4 
               
               
                   
                 153627_Breast cancer (D34) 
                 5.8 
                 3.6 
               
               
                   
                 153636_Breast cancer (D3D) 
                 7.8 
                 4.9 
               
               
                   
                 164668_Breast cancer (6314) 
                 0.5 
                 0.2 
               
               
                   
                 164677_Breast cancer (5272) 
                 21.6 
                 17.3 
               
               
                   
                 164685_Breast cancer (0170) 
                 80.1 
                 50.7 
               
               
                   
                 98857_Breast cancer (OD06397-12) 
                 2.3 
                 1.2 
               
               
                   
                 111288_Breast NAT (3367) 
                 14.6 
                 6.2 
               
               
                   
                 116424_Breast cancer 4B* 
                 0.2 
                 0.2 
               
               
                   
                 153628_Breast cancer (D35) 
                 18.9 
                 11.7 
               
               
                   
                 153637_Breast cancer (D3E) 
                 1.3 
                 0.9 
               
               
                   
                 164669_Breast cancer (6992) 
                 16.0 
                 9.6 
               
               
                   
                 164678_Breast cancer (5297) 
                 50.0 
                 42.6 
               
               
                   
                 164686_Breast cancer (0732) 
                 0.8 
                 0.5 
               
               
                   
                 105687_Breast cancer 1B 
                 0.1 
                 0.1 
               
               
                   
                 111289_Breast cancer 3B* 
                 8.2 
                 5.7 
               
               
                   
                 116425_Breast NAT 4A 
                 0.3 
                 0.3 
               
               
                   
                 145857_Breast cancer (9F0) 
                 8.8 
                 8.0 
               
               
                   
                 153630_Breast cancer (D37) 
                 2.0 
                 2.0 
               
               
                   
                 153638_Breast cancer (D3F) 
                 11.0 
                 10.0 
               
               
                   
                 164670_Breast cancer (7078) 
                 1.7 
                 2.7 
               
               
                   
                 164679_Breast cancer (5486) 
                 15.8 
                 13.9 
               
               
                   
                 164687_Breast cancer (5881) 
                 11.2 
                 4.0 
               
               
                   
                 105688_Breast NAT 1A 
                 0.2 
                 0.1 
               
               
                   
                 111290_Breast NAT 3A* 
                 4.2 
                 6.8 
               
               
                   
                 145846_Breast cancer (9B7) 
                 7.1 
                 9.6 
               
               
                   
                 145858_Breast cancer (9B4) 
                 0.9 
                 1.4 
               
               
                   
                 153631_Breast cancer (D38) 
                 0.3 
                 0.2 
               
               
                   
                 153639_Breast cancer (D40) 
                 66.0 
                 29.3 
               
               
                   
                 164671_Breast cancer (7082) 
                 62.4 
                 50.0 
               
               
                   
                 164680_Breast cancer (5705) 
                 1.7 
                 1.3 
               
               
                   
                 164688_Breast cancer (7222) 
                 1.5 
                 0.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1395, Run 399018961    
               
               
                   
                   Column B - Rel. Exp. (%) Ag8392, Run 398657263    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XD 
               
             
            
               
                   
               
               
                   
               
               
                 Ardais Panel 1.1 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Lung adenocarcinoma SI A 
                 15.6 
                 8.7 
               
               
                   
                 Lung adenocarcinoma SI B 
                 22.2 
                 75.3 
               
               
                   
                 Lung adenocarcinoma SI B NAT 
                 100.0 
                 70.7 
               
               
                   
                 Lung adenocarcinoma SI C 
                 1.6 
                 3.4 
               
               
                   
                 Lung adenocarcinoma SI C NAT 
                 98.6 
                 100.0 
               
               
                   
                 Lung adenocarcinoma SII A 
                 11.7 
                 14.5 
               
               
                   
                 Lung adenocarcinoma SII A NAT 
                 58.6 
                 76.3 
               
               
                   
                 Lung adenocarcinoma SII C NAT 
                 62.4 
                 55.5 
               
               
                   
                 Lung adenocarcinoma SIII A 
                 41.5 
                 42.9 
               
               
                   
                 Lung adenocarcinoma SIII B 
                 32.1 
                 33.7 
               
               
                   
                 Lung adenocarcinoma SIII C 
                 16.8 
                 25.2 
               
               
                   
                 Lung SCC SI A 
                 27.9 
                 74.7 
               
               
                   
                 Lung SCC SI B NAT 
                 77.4 
                 33.4 
               
               
                   
                 Lung SCC SI C 
                 23.3 
                 31.0 
               
               
                   
                 Lung SCC SI C NAT 
                 71.2 
                 82.9 
               
               
                   
                 Lung SCC SI D 
                 40.6 
                 62.4 
               
               
                   
                 Lung SCC SI D NAT 
                 32.5 
                 59.9 
               
               
                   
                 Lung SCC SII A 
                 15.4 
                 60.3 
               
               
                   
                 Lung SCC SII B 
                 7.0 
                 11.7 
               
               
                   
                 Lung SCC SIII A 
                 11.5 
                 11.5 
               
               
                   
                 Lung SCC SIII A NAT 
                 29.1 
                 13.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1395, Run 332737494    
               
               
                   
                   Column B - Rel. Exp. (%) Ag8392, Run 369781003    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XE 
               
             
            
               
                   
               
               
                   
               
               
                 Ardais Prostate 1.0 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 145904_Prostate cancer(9E2) 
                 100.0 
                 100.0 
               
               
                   
                 149776_Prostate cancer(ADS) 
                 17.4 
                 20.0 
               
               
                   
                 151135_Prostate NAT(B87) 
                 0.4 
                 0.2 
               
               
                   
                 151143_Prostate NAT(B8A) 
                 0.3 
                 0.2 
               
               
                   
                 153653_Prostate cancer(D4E) 
                 0.7 
                 0.7 
               
               
                   
                 153661_Prostate cancer(D56) 
                 1.2 
                 0.7 
               
               
                   
                 153669_Prostate NAT(D5E) 
                 1.2 
                 0.6 
               
               
                   
                 153677_Prostate NAT(D66) 
                 0.2 
                 0.1 
               
               
                   
                 153685_Prostate NAT(D6E) 
                 0.2 
                 0.1 
               
               
                   
                 145905_Prostate NAT(A0C) 
                 1.0 
                 0.7 
               
               
                   
                 151128_Prostate cancer(B8C) 
                 0.6 
                 0.9 
               
               
                   
                 151136_Prostate cancer(B8B) 
                 3.3 
                 2.1 
               
               
                   
                 151144_Prostate cancer(B8F) 
                 0.4 
                 0.2 
               
               
                   
                 153654_Prostate cancer(D4F) 
                 4.5 
                 3.8 
               
               
                   
                 153662_Prostate cancer(D57) 
                 0.2 
                 0.0 
               
               
                   
                 153670_Prostate NAT(D5F) 
                 1.1 
                 0.6 
               
               
                   
                 153678_Prostate NAT(D67) 
                 0.3 
                 0.1 
               
               
                   
                 153686_Prostate NAT(D6F) 
                 0.2 
                 0.2 
               
               
                   
                 145906_Prostate NAT(A09) 
                 0.4 
                 0.3 
               
               
                   
                 151129_Prostate NAT(B93) 
                 0.7 
                 0.6 
               
               
                   
                 151137_Prostate NAT(B86) 
                 0.3 
                 0.4 
               
               
                   
                 151145_Prostate NAT(B91) 
                 0.4 
                 0.3 
               
               
                   
                 153655_Prostate cancer(D50) 
                 0.7 
                 0.4 
               
               
                   
                 153663_Prostate cancer(D58) 
                 0.1 
                 0.0 
               
               
                   
                 153671_Prostate NAT(D60) 
                 0.2 
                 0.6 
               
               
                   
                 153679_Prostate NAT(D68) 
                 0.2 
                 0.2 
               
               
                   
                 153687_Prostate NAT(D70) 
                 0.4 
                 0.3 
               
               
                   
                 145907_Prostate cancer(A0A) 
                 0.4 
                 0.3 
               
               
                   
                 151130_Prostate cancer(B90) 
                 1.4 
                 1.1 
               
               
                   
                 151138_Prostate cancer(B8D) 
                 11.6 
                 11.3 
               
               
                   
                 153648_Prostate cancer(D49) 
                 2.1 
                 1.8 
               
               
                   
                 153656_Prostate cancer(D51) 
                 0.4 
                 0.1 
               
               
                   
                 153664_Prostate cancer(D59) 
                 1.2 
                 0.9 
               
               
                   
                 153672_Prostate NAT(D61) 
                 0.3 
                 0.7 
               
               
                   
                 153680_Prostate NAT(D69) 
                 0.3 
                 0.3 
               
               
                   
                 155799_Prostate cancer(EA8) 
                 2.6 
                 3.8 
               
               
                   
                 145909_Prostate cancer(9E7) 
                 3.1 
                 4.4 
               
               
                   
                 151131_Prostate NAT(B85) 
                 1.2 
                 0.6 
               
               
                   
                 151139_Prostate NAT(B8E) 
                 0.4 
                 0.3 
               
               
                   
                 153649_Prostate cancer(D4A) 
                 0.7 
                 0.4 
               
               
                   
                 153657_Prostate cancer(D52) 
                 0.6 
                 0.2 
               
               
                   
                 153665_Prostate cancer(D5A) 
                 34.6 
                 25.7 
               
               
                   
                 153673_Prostate NAT(D62) 
                 0.6 
                 0.3 
               
               
                   
                 153681_Prostate NAT(D6A) 
                 0.2 
                 0.1 
               
               
                   
                 145910_Prostate NAT(9C3) 
                 1.0 
                 0.4 
               
               
                   
                 151132_Prostate cancer(B88) 
                 12.9 
                 7.4 
               
               
                   
                 151140_Prostate cancer(B95) 
                 0.8 
                 0.4 
               
               
                   
                 153650_Prostate cancer(D4B) 
                 3.7 
                 3.1 
               
               
                   
                 153658_Prostate cancer(D53) 
                 1.2 
                 0.4 
               
               
                   
                 153666_Prostate cancer(D5B) 
                 15.7 
                 14.3 
               
               
                   
                 153674_Prostate NAT(D63) 
                 1.1 
                 0.3 
               
               
                   
                 153682_Prostate NAT(D6B) 
                 0.9 
                 0.6 
               
               
                   
                 149773_Prostate NAT(AD8) 
                 0.0 
                 0.0 
               
               
                   
                 151133_Prostate NAT(B94) 
                 0.5 
                 0.4 
               
               
                   
                 151141_Prostate NAT(B96) 
                 1.1 
                 0.8 
               
               
                   
                 153651_Prostate cancer(D4C) 
                 11.1 
                 9.7 
               
               
                   
                 153659_Prostate cancer(D54) 
                 3.5 
                 3.0 
               
               
                   
                 153667_Prostate cancer(D5C) 
                 0.6 
                 0.3 
               
               
                   
                 153675_Prostate NAT(D64) 
                 1.2 
                 0.4 
               
               
                   
                 153683_Prostate NAT(D6C) 
                 0.8 
                 0.3 
               
               
                   
                 149774_Prostate cancer(AD7) 
                 0.9 
                 1.1 
               
               
                   
                 151134_Prostate cancer(B92) 
                 0.4 
                 0.2 
               
               
                   
                 151142_Prostate cancer(B89) 
                 40.9 
                 40.9 
               
               
                   
                 153652_Prostate cancer(D4D) 
                 0.6 
                 0.3 
               
               
                   
                 153660_Prostate cancer(D55) 
                 12.8 
                 11.5 
               
               
                   
                 153668_Prostate NAT(D5D) 
                 0.4 
                 0.3 
               
               
                   
                 153676_Prostate NAT(D65) 
                 0.7 
                 0.4 
               
               
                   
                 153684_Prostate NAT(D6D) 
                 0.3 
                 0.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1395, Run 379587273    
               
               
                   
                   Column B - Rel. Exp. (%) Ag8392, Run 369780997    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XF 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.6 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 0.5 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma* M14 
                 0.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.3 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.4 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 1.5 
               
               
                   
                 Testis Pool 
                 1.3 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate Pool 
                 0.2 
               
               
                   
                 Placenta 
                 0.1 
               
               
                   
                 Uterus Pool 
                 0.2 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.1 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 1.3 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 1.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 39.8 
               
               
                   
                 Ovarian ca. IGROV-1 
                 21.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 3.4 
               
               
                   
                 Ovary 
                 0.5 
               
               
                   
                 Breast ca. MCF-7 
                 1.6 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.1 
               
               
                   
                 Breast ca. BT 549 
                 0.1 
               
               
                   
                 Breast ca. T47D 
                 0.4 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Breast Pool 
                 0.6 
               
               
                   
                 Trachea 
                 0.8 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Fetal Lung 
                 0.8 
               
               
                   
                 Lung ca. NCI-N417 
                 7.9 
               
               
                   
                 Lung ca. LX-1 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 1.3 
               
               
                   
                 Lung ca. SHP-77 
                 6.2 
               
               
                   
                 Lung ca. A549 
                 0.2 
               
               
                   
                 Lung ca. NCI-H526 
                 3.0 
               
               
                   
                 Lung ca. NCI-H23 
                 1.6 
               
               
                   
                 Lung ca. NCI-H460 
                 0.5 
               
               
                   
                 Lung ca. HOP-62 
                 0.0 
               
               
                   
                 Lung ca. NCI-H522 
                 17.9 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 0.3 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
               
               
                   
                 Kidney Pool 
                 0.4 
               
               
                   
                 Fetal Kidney 
                 0.2 
               
               
                   
                 Renal ca. 786-0 
                 1.4 
               
               
                   
                 Renal ca. A498 
                 21.6 
               
               
                   
                 Renal ca. ACHN 
                 6.2 
               
               
                   
                 Renal ca. UO-31 
                 0.6 
               
               
                   
                 Renal ca. TK-10 
                 10.9 
               
               
                   
                 Bladder 
                 1.2 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.0 
               
               
                   
                 Gastric ca. KATO III 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 6.6 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.8 
               
               
                   
                 Colon ca. HT29 
                 0.3 
               
               
                   
                 Colon ca. HCT-116 
                 15.5 
               
               
                   
                 Colon ca. CaCo-2 
                 0.6 
               
               
                   
                 Colon cancer tissue 
                 0.6 
               
               
                   
                 Colon ca. SW1116 
                 4.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.1 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 0.8 
               
               
                   
                 Small Intestine Pool 
                 0.4 
               
               
                   
                 Stomach Pool 
                 0.5 
               
               
                   
                 Bone Marrow Pool 
                 0.2 
               
               
                   
                 Fetal Heart 
                 0.2 
               
               
                   
                 Heart Pool 
                 0.1 
               
               
                   
                 Lymph Node Pool 
                 0.8 
               
               
                   
                 Fetal Skeletal Muscle 
                 0.8 
               
               
                   
                 Skeletal Muscle Pool 
                 0.1 
               
               
                   
                 Spleen Pool 
                 1.0 
               
               
                   
                 Thymus Pool 
                 1.5 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 0.1 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 2.5 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 0.9 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 19.5 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.7 
               
               
                   
                 Brain (Amygdala) Pool 
                 38.4 
               
               
                   
                 Brain (cerebellum) 
                 100.0 
               
               
                   
                 Brain (fetal) 
                 62.4 
               
               
                   
                 Brain (Hippocampus) Pool 
                 36.9 
               
               
                   
                 Cerebral Cortex Pool 
                 72.2 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 48.0 
               
               
                   
                 Brain (Thalamus) Pool 
                 46.7 
               
               
                   
                 Brain (whole) 
                 72.2 
               
               
                   
                 Spinal Cord Pool 
                 3.2 
               
               
                   
                 Adrenal Gland 
                 11.3 
               
               
                   
                 Pituitary gland Pool 
                 2.8 
               
               
                   
                 Salivary Gland 
                 0.5 
               
               
                   
                 Thyroid (female) 
                 0.1 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 1.0 
               
               
                   
                 Pancreas Pool 
                 0.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1395, Run 277226632    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XG 
               
             
            
               
                   
               
               
                   
               
               
                 HASS Panel v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 MCF-7 C1 
                 7.5 
               
               
                   
                 MCF-7 C2 
                 7.1 
               
               
                   
                 MCF-7 C3 
                 4.0 
               
               
                   
                 MCF-7 C4 
                 12.5 
               
               
                   
                 MCF-7 C5 
                 9.1 
               
               
                   
                 MCF-7 C6 
                 12.5 
               
               
                   
                 MCF-7 C7 
                 5.2 
               
               
                   
                 MCF-7 C9 
                 5.0 
               
               
                   
                 MCF-7 C10 
                 8.2 
               
               
                   
                 MCF-7 C11 
                 1.2 
               
               
                   
                 MCF-7 C12 
                 5.1 
               
               
                   
                 MCF-7 C13 
                 2.1 
               
               
                   
                 MCF-7 C15 
                 3.6 
               
               
                   
                 MCF-7 C16 
                 13.9 
               
               
                   
                 MCF-7 C17 
                 8.9 
               
               
                   
                 T24 D1 
                 0.1 
               
               
                   
                 T24 D2 
                 0.1 
               
               
                   
                 T24 D3 
                 0.1 
               
               
                   
                 T24 D4 
                 0.4 
               
               
                   
                 T24 D5 
                 0.2 
               
               
                   
                 T24 D6 
                 0.1 
               
               
                   
                 T24 D7 
                 0.2 
               
               
                   
                 T24 D9 
                 0.1 
               
               
                   
                 T24 D10 
                 0.0 
               
               
                   
                 T24 D11 
                 0.1 
               
               
                   
                 T24 D12 
                 0.0 
               
               
                   
                 T24 D13 
                 0.2 
               
               
                   
                 T24 D15 
                 0.1 
               
               
                   
                 T24 D16 
                 0.0 
               
               
                   
                 T24 D17 
                 0.1 
               
               
                   
                 CAPaN B1 
                 13.0 
               
               
                   
                 CAPaN B2 
                 11.6 
               
               
                   
                 CAPaN B3 
                 5.0 
               
               
                   
                 CAPaN B4 
                 12.7 
               
               
                   
                 CAPaN B5 
                 18.4 
               
               
                   
                 CAPaN B6 
                 11.2 
               
               
                   
                 CAPaN B7 
                 3.8 
               
               
                   
                 CAPaN B8 
                 3.7 
               
               
                   
                 CAPaN B9 
                 7.5 
               
               
                   
                 CAPaN B10 
                 20.0 
               
               
                   
                 CAPaN B11 
                 26.8 
               
               
                   
                 CAPaN B12 
                 14.6 
               
               
                   
                 CAPaN B13 
                 5.1 
               
               
                   
                 CAPaN B14 
                 5.9 
               
               
                   
                 CAPaN B15 
                 8.0 
               
               
                   
                 CAPaN B16 
                 13.8 
               
               
                   
                 CAPaN B17 
                 13.7 
               
               
                   
                 U87-MG F1 (B) 
                 0.0 
               
               
                   
                 U87-MG F2 
                 0.0 
               
               
                   
                 U87-MG F3 
                 0.1 
               
               
                   
                 U87-MG F4 
                 0.0 
               
               
                   
                 U87-MG F5 
                 0.0 
               
               
                   
                 U87-MG F6 
                 0.1 
               
               
                   
                 U87-MG F7 
                 0.0 
               
               
                   
                 U87-MG F8 
                 0.1 
               
               
                   
                 U87-MG F9 
                 0.1 
               
               
                   
                 U87-MG F10 
                 0.0 
               
               
                   
                 U87-MG F11 
                 0.0 
               
               
                   
                 U87-MG F12 
                 0.0 
               
               
                   
                 U87-MG F13 
                 0.0 
               
               
                   
                 U87-MG F14 
                 0.0 
               
               
                   
                 U87-MG F15 
                 0.0 
               
               
                   
                 U87-MG F16 
                 0.0 
               
               
                   
                 U87-MG F17 
                 0.1 
               
               
                   
                 LnCAP A1 
                 0.9 
               
               
                   
                 LnCAP A2 
                 0.5 
               
               
                   
                 LnCAP A3 
                 0.9 
               
               
                   
                 LnCAP A4 
                 1.0 
               
               
                   
                 LnCAP A5 
                 1.2 
               
               
                   
                 LnCAP A6 
                 0.4 
               
               
                   
                 LnCAP A7 
                 0.7 
               
               
                   
                 LnCAP A8 
                 1.2 
               
               
                   
                 LnCAP A9 
                 1.1 
               
               
                   
                 LnCAP A10 
                 1.0 
               
               
                   
                 LnCAP A11 
                 1.6 
               
               
                   
                 LnCAP A12 
                 0.0 
               
               
                   
                 LnCAP A13 
                 0.4 
               
               
                   
                 LnCAP A14 
                 1.2 
               
               
                   
                 LnCAP A15 
                 0.3 
               
               
                   
                 LnCAP A16 
                 1.1 
               
               
                   
                 LnCAP A17 
                 1.3 
               
               
                   
                 Primary Astrocytes 
                 0.2 
               
               
                   
                 Primary Renal Proximal Tubule Epithelial cell A2 
                 1.5 
               
               
                   
                 Primary melanocytes A5 
                 0.0 
               
               
                   
                 126443 - 341 medullo 
                 0.0 
               
               
                   
                 126444 - 487 medullo 
                 0.5 
               
               
                   
                 126445 - 425 medullo 
                 0.0 
               
               
                   
                 126446 - 690 medullo 
                 100.0 
               
               
                   
                 126447 - 54 adult glioma 
                 0.8 
               
               
                   
                 126448 - 245 adult glioma 
                 0.1 
               
               
                   
                 126449 - 317 adult glioma 
                 0.1 
               
               
                   
                 126450 - 212 glioma 
                 0.0 
               
               
                   
                 126451 - 456 glioma 
                 0.1 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1395, Run 268623664    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Normal Colon 
                 4.2 
                 1.9 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 0.7 
                 1.8 
               
               
                   
                 CC Margin (ODO3866) 
                 0.0 
                 1.0 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 0.0 
                 1.1 
               
               
                   
                 CC Margin (ODO3868) 
                 0.0 
                 0.0 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 0.0 
                 1.2 
               
               
                   
                 CC Margin (ODO3920) 
                 0.0 
                 0.8 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 0.9 
                 2.3 
               
               
                   
                 CC Margin (ODO3921) 
                 0.0 
                 0.4 
               
               
                   
                 CC from Partial Hepatectomy 
                 0.7 
                 0.2 
               
               
                   
                 (ODO4309) Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 0.0 
                 0.9 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 0.0 
                 2.3 
               
               
                   
                 Lung Margin (OD04451-02) 
                 0.8 
                 0.0 
               
               
                   
                 Normal Prostate 6546-1 
                 9.0 
                 8.2 
               
               
                   
                 Prostate Cancer (OD04410) 
                 0.0 
                 3.5 
               
               
                   
                 Prostate Margin (OD04410) 
                 2.0 
                 1.7 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 0.8 
                 1.7 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 0.0 
                 1.5 
               
               
                   
                 Normal Lung 061010 
                 3.1 
                 10.9 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 4.4 
                 4.1 
               
               
                   
                 Muscle Margin (ODO4286) 
                 0.0 
                 0.5 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 2.2 
                 2.5 
               
               
                   
                 Lung Margin (OD03126) 
                 3.2 
                 4.6 
               
               
                   
                 Lung Cancer (OD04404) 
                 2.4 
                 1.1 
               
               
                   
                 Lung Margin (OD04404) 
                 3.3 
                 4.2 
               
               
                   
                 Lung Cancer (OD04565) 
                 0.0 
                 1.6 
               
               
                   
                 Lung Margin (OD04565) 
                 1.7 
                 1.7 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 0.8 
                 4.5 
               
               
                   
                 Lung Margin (OD04237-02) 
                 3.8 
                 7.1 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 0.0 
                 0.0 
               
               
                   
                 Liver Margin (ODO4310) 
                 6.2 
                 2.1 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.8 
                 0.0 
               
               
                   
                 Lung Margin (OD04321) 
                 3.8 
                 5.3 
               
               
                   
                 Normal Kidney 
                 0.8 
                 1.6 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 1.2 
                 2.8 
               
               
                   
                 Kidney Margin (OD04338) 
                 0.0 
                 1.8 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 
                 5.9 
                 5.4 
               
               
                   
                 (OD04339) 
               
               
                   
                 Kidney Margin (OD04339) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 1.3 
                 7.4 
               
               
                   
                 Kidney Margin (OD04340) 
                 0.0 
                 0.3 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.0 
                 2.1 
               
               
                   
                 Kidney Margin (OD04348) 
                 0.8 
                 0.8 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 2.2 
                 4.0 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 0.7 
                 0.4 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.0 
                 0.4 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Cancer 8120607 
                 27.9 
                 60.3 
               
               
                   
                 Kidney Margin 8120608 
                 0.8 
                 2.1 
               
               
                   
                 Kidney Cancer 8120613 
                 0.8 
                 1.7 
               
               
                   
                 Kidney Margin 8120614 
                 0.7 
                 0.7 
               
               
                   
                 Kidney Cancer 9010320 
                 4.7 
                 6.3 
               
               
                   
                 Kidney Margin 9010321 
                 0.0 
                 2.7 
               
               
                   
                 Normal Uterus 
                 0.0 
                 2.2 
               
               
                   
                 Uterus Cancer 064011 
                 0.0 
                 8.9 
               
               
                   
                 Normal Thyroid 
                 8.7 
                 1.2 
               
               
                   
                 Thyroid Cancer 064010 
                 0.0 
                 0.0 
               
               
                   
                 Thyroid Cancer A302152 
                 0.0 
                 2.5 
               
               
                   
                 Thyroid Margin A302153 
                 1.1 
                 0.8 
               
               
                   
                 Normal Breast 
                 2.8 
                 4.1 
               
               
                   
                 Breast Cancer (OD04566) 
                 0.0 
                 1.8 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 28.3 
                 27.4 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 13.3 
                 14.2 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 37.9 
                 100.0 
               
               
                   
                 Breast Cancer 064006 
                 12.0 
                 19.2 
               
               
                   
                 Breast Cancer 1024 
                 33.9 
                 25.2 
               
               
                   
                 Breast Cancer 9100266 
                 6.7 
                 7.6 
               
               
                   
                 Breast Margin 9100265 
                 0.5 
                 9.2 
               
               
                   
                 Breast Cancer A209073 
                 3.7 
                 6.8 
               
               
                   
                 Breast Margin A209073 
                 0.7 
                 0.0 
               
               
                   
                 Normal Liver 
                 0.0 
                 2.6 
               
               
                   
                 Liver Cancer 064003 
                 0.0 
                 1.3 
               
               
                   
                 Liver Cancer 1025 
                 0.4 
                 2.0 
               
               
                   
                 Liver Cancer 1026 
                 0.0 
                 1.6 
               
               
                   
                 Liver Cancer 6004-T 
                 1.6 
                 3.3 
               
               
                   
                 Liver Tissue 6004-N 
                 1.4 
                 0.7 
               
               
                   
                 Liver Cancer 6005-T 
                 0.8 
                 0.8 
               
               
                   
                 Liver Tissue 6005-N 
                 0.0 
                 0.0 
               
               
                   
                 Normal Bladder 
                 3.5 
                 3.8 
               
               
                   
                 Bladder Cancer 1023 
                 0.8 
                 0.5 
               
               
                   
                 Bladder Cancer A302173 
                 3.2 
                 1.1 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 3.8 
                 2.3 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 5.2 
                 7.4 
               
               
                   
                 Normal Ovary 
                 3.0 
                 2.9 
               
               
                   
                 Ovarian Cancer 064008 
                 3.2 
                 2.9 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 3.5 
                 4.6 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 0.9 
                 2.2 
               
               
                   
                 Normal Stomach 
                 2.7 
                 3.7 
               
               
                   
                 Gastric Cancer 9060358 
                 0.4 
                 0.2 
               
               
                   
                 Stomach Margin 9060359 
                 4.3 
                 1.3 
               
               
                   
                 Gastric Cancer 9060395 
                 3.0 
                 1.2 
               
               
                   
                 Stomach Margin 9060394 
                 2.5 
                 1.0 
               
               
                   
                 Gastric Cancer 9060397 
                 100.0 
                 48.0 
               
               
                   
                 Stomach Margin 9060396 
                 1.0 
                 2.2 
               
               
                   
                 Gastric Cancer 064005 
                 4.9 
                 6.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1395, Run 145711201    
               
               
                   
                   Column B - Rel. Exp. (%) Ag1395, Run 162599933    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XI 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Daoy- Medulloblastoma 
                 0.0 
               
               
                   
                 TE671- Medulloblastoma 
                 0.6 
               
               
                   
                 D283 Med- Medulloblastoma 
                 0.5 
               
               
                   
                 PFSK-1- Primitive Neuroectodermal 
                 0.0 
               
               
                   
                 XF-498- CNS 
                 0.6 
               
               
                   
                 SNB-78- Glioma 
                 0.0 
               
               
                   
                 SF-268- Glioblastoma 
                 0.0 
               
               
                   
                 T98G- Glioblastoma 
                 6.5 
               
               
                   
                 SK-N-SH- Neuroblastoma (metastasis) 
                 10.3 
               
               
                   
                 SF-295- Glioblastoma 
                 0.8 
               
               
                   
                 Cerebellum 
                 46.0 
               
               
                   
                 Cerebellum 
                 41.5 
               
               
                   
                 NCI-H292- Mucoepidermoid lung carcinoma 
                 0.4 
               
               
                   
                 DMS-114- Small cell lung cancer 
                 9.0 
               
               
                   
                 DMS-79- Small cell lung cancer 
                 100.0 
               
               
                   
                 NCI-H146- Small cell lung cancer 
                 4.2 
               
               
                   
                 NCI-H526- Small cell lung cancer 
                 16.5 
               
               
                   
                 NCI-N417- Small cell lung cancer 
                 22.8 
               
               
                   
                 NCI-H82- Small cell lung cancer 
                 9.5 
               
               
                   
                 NCI-H157- Squamous cell lung cancer (metastasis) 
                 0.0 
               
               
                   
                 NCI-H1155- Large cell lung cancer 
                 27.7 
               
               
                   
                 NCI-H1299- Large cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H727- Lung carcinoid 
                 14.5 
               
               
                   
                 NCI-UMC-11- Lung carcinoid 
                 22.1 
               
               
                   
                 LX-1- Small cell lung cancer 
                 0.2 
               
               
                   
                 Colo-205- Colon cancer 
                 0.2 
               
               
                   
                 KM12- Colon cancer 
                 0.0 
               
               
                   
                 KM20L2- Colon cancer 
                 0.2 
               
               
                   
                 NCI-H716- Colon cancer 
                 0.4 
               
               
                   
                 SW-48- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW1116- Colon adenocarcinoma 
                 7.2 
               
               
                   
                 LS 174T- Colon adenocarcinoma 
                 0.9 
               
               
                   
                 SW-948- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-480- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-5- Gastric carcinoma 
                 3.5 
               
               
                   
                 KATO III- Gastric carcinoma 
                 0.3 
               
               
                   
                 NCI-SNU-16- Gastric carcinoma 
                 2.1 
               
               
                   
                 NCI-SNU-1- Gastric carcinoma 
                 0.0 
               
               
                   
                 RF-1- Gastric adenocarcinoma 
                 0.0 
               
               
                   
                 RF-48- Gastric adenocarcinoma 
                 0.0 
               
               
                   
                 MKN-45- Gastric carcinoma 
                 2.9 
               
               
                   
                 NCI-N87- Gastric carcinoma 
                 0.0 
               
               
                   
                 OVCAR-5- Ovarian carcinoma 
                 11.2 
               
               
                   
                 RL95-2- Uterine carcinoma 
                 0.0 
               
               
                   
                 HelaS3- Cervical adenocarcinoma 
                 0.0 
               
               
                   
                 Ca Ski- Cervical epidermoid carcinoma 
                 0.0 
               
               
                   
                 (metastasis) 
               
               
                   
                 ES-2- Ovarian clear cell carcinoma 
                 0.2 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 0.0 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 0.0 
               
               
                   
                 MEG-01- Chronic myelogenous leukemia 
                 0.0 
               
               
                   
                 (megokaryoblast) 
               
               
                   
                 Raji- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 Daudi- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 U266- B-cell plasmacytoma 
                 0.0 
               
               
                   
                 CA46- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 0.0 
               
               
                   
                 JM1- pre-B-cell lymphoma 
                 0.0 
               
               
                   
                 Jurkat- T cell leukemia 
                 0.0 
               
               
                   
                 TF-1- Erythroleukemia 
                 0.0 
               
               
                   
                 HUT 78- T-cell lymphoma 
                 0.0 
               
               
                   
                 U937- Histiocytic lymphoma 
                 5.3 
               
               
                   
                 KU-812- Myelogenous leukemia 
                 0.0 
               
               
                   
                 769-P- Clear cell renal carcinoma 
                 6.3 
               
               
                   
                 Caki-2- Clear cell renal carcinoma 
                 15.8 
               
               
                   
                 SW 839- Clear cell renal carcinoma 
                 5.9 
               
               
                   
                 Rhabdoid kidney tumor 
                 1.2 
               
               
                   
                 Hs766T- Pancreatic carcinoma (LN 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 CAPAN-1- Pancreatic adenocarcinoma (liver 
                 27.7 
               
               
                   
                 metastasis) 
               
               
                   
                 SU86.86- Pancreatic carcinoma (liver 
                 11.0 
               
               
                   
                 metastasis) 
               
               
                   
                 BxPC-3- Pancreatic adenocarcinoma 
                 0.0 
               
               
                   
                 HPAC- Pancreatic adenocarcinoma 
                 0.0 
               
               
                   
                 MIA PaCa-2- Pancreatic carcinoma 
                 0.0 
               
               
                   
                 CFPAC-1- Pancreatic ductal adenocarcinoma 
                 2.8 
               
               
                   
                 PANC-1- Pancreatic epithelioid ductal 
                 0.2 
               
               
                   
                 carcinoma 
               
               
                   
                 T24- Bladder carcinma (transitional cell) 
                 0.0 
               
               
                   
                 5637- Bladder carcinoma 
                 0.2 
               
               
                   
                 HT-1197- Bladder carcinoma 
                 0.0 
               
               
                   
                 UM-UC-3- Bladder carcinma (transitional cell) 
                 0.3 
               
               
                   
                 A204- Rhabdomyosarcoma 
                 1.0 
               
               
                   
                 HT-1080- Fibrosarcoma 
                 0.0 
               
               
                   
                 MG-63- Osteosarcoma 
                 0.2 
               
               
                   
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 0.0 
               
               
                   
                 SJRH30- Rhabdomyosarcoma (met to bone 
                 0.1 
               
               
                   
                 marrow) 
               
               
                   
                 A431- Epidermoid carcinoma 
                 0.0 
               
               
                   
                 WM266-4- Melanoma 
                 0.0 
               
               
                   
                 DU 145- Prostate carcinoma (brain 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 MDA-MB-468- Breast adenocarcinoma 
                 9.2 
               
               
                   
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-9- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 CAL 27- Squamous cell carcinoma of tongue 
                 4.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1395, Run 163477780    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XJ 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Secondary Th1 act 
                 0.0 
                 1.5 
               
               
                 Secondary Th2 act 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 act 
                 0.0 
                 0.0 
               
               
                 Secondary Th1 rest 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 rest 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 rest 
                 0.0 
                 0.0 
               
               
                 Primary Th1 act 
                 0.0 
                 0.0 
               
               
                 Primary Th2 act 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 act 
                 1.6 
                 0.0 
               
               
                 Primary Th1 rest 
                 1.7 
                 0.0 
               
               
                 Primary Th2 rest 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 rest 
                 1.3 
                 0.0 
               
               
                 CD45RA CD4 lymphocyte act 
                 0.0 
                 0.7 
               
               
                 CD45RO CD4 lymphocyte act 
                 1.2 
                 0.0 
               
               
                 CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte rest 
                 1.2 
                 0.0 
               
               
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD4 lymphocyte none 
                 0.0 
                 0.0 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 1.6 
                 0.0 
               
               
                 LAK cells rest 
                 41.8 
                 49.7 
               
               
                 LAK cells IL-2 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-12 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IFN gamma 
                 4.2 
                 2.9 
               
               
                 LAK cells IL-2 + IL-18 
                 2.7 
                 1.5 
               
               
                 LAK cells PMA/ionomycin 
                 63.3 
                 100.0 
               
               
                 NK Cells IL-2 rest 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 3 day 
                 21.8 
                 16.7 
               
               
                 Two Way MLR 5 day 
                 4.6 
                 2.2 
               
               
                 Two Way MLR 7 day 
                 5.0 
                 2.5 
               
               
                 PBMC rest 
                 3.6 
                 9.5 
               
               
                 PBMC PWM 
                 0.0 
                 97.9 
               
               
                 PBMC PHA-L 
                 2.9 
                 2.7 
               
               
                 Ramos (B cell) none 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
               
               
                 B lymphocytes PWM 
                 13.8 
                 0.0 
               
               
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP 
                 0.0 
                 4.4 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 1.3 
               
               
                 Dendritic cells none 
                 31.9 
                 34.4 
               
               
                 Dendritic cells LPS 
                 36.3 
                 23.3 
               
               
                 Dendritic cells anti-CD40 
                 39.8 
                 40.3 
               
               
                 Monocytes rest 
                 55.9 
                 58.6 
               
               
                 Monocytes LPS 
                 13.3 
                 11.3 
               
               
                 Macrophages rest 
                 93.3 
                 96.6 
               
               
                 Macrophages LPS 
                 38.7 
                 28.3 
               
               
                 HUVEC none 
                 0.0 
                 4.0 
               
               
                 HUVEC starved 
                 2.6 
                 0.0 
               
               
                 HUVEC IL-1beta 
                 0.0 
                 1.4 
               
               
                 HUVEC IFN gamma 
                 1.5 
                 6.3 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IL4 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-11 
                 1.4 
                 0.0 
               
               
                 Lung Microvascular EC none 
                 0.0 
                 1.4 
               
               
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
                 0.7 
               
               
                 Microvascular Dermal EC none 
                 11.0 
                 5.5 
               
               
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 7.6 
                 17.4 
               
               
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
                 0.0 
               
               
                 Small airway epithelium none 
                 0.0 
                 0.0 
               
               
                 Small airway epithelium TNFalpha + IL-1beta 
                 1.1 
                 1.9 
               
               
                 Coronery artery SMC rest 
                 0.0 
                 0.0 
               
               
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Astrocytes rest 
                 1.5 
                 0.0 
               
               
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
                 1.2 
               
               
                 KU-812 (Basophil) rest 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
                 2.6 
               
               
                 CCD1106 (Keratinocytes) none 
                 0.0 
                 1.1 
               
               
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 12.5 
                 12.3 
               
               
                 Liver cirrhosis 
                 23.8 
                 21.0 
               
               
                 Lupus kidney 
                 3.0 
                 2.0 
               
               
                 NCI-H292 none 
                 1.1 
                 5.8 
               
               
                 NCI-H292 IL-4 
                 2.1 
                 6.4 
               
               
                 NCI-H292 IL-9 
                 3.8 
                 0.0 
               
               
                 NCI-H292 IL-13 
                 0.0 
                 4.2 
               
               
                 NCI-H292 IFN gamma 
                 7.1 
                 7.1 
               
               
                 HPAEC none 
                 10.4 
                 13.4 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast none 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-4 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-9 
                 0.0 
                 5.5 
               
               
                 Lung fibroblast IL-13 
                 1.3 
                 0.0 
               
               
                 Lung fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 rest 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
                 5.6 
               
               
                 Dermal fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast IL-4 
                 0.0 
                 0.0 
               
               
                 IBD Colitis 2 
                 0.0 
                 1.5 
               
               
                 IBD Crohn&#39;s 
                 1.4 
                 0.0 
               
               
                 Colon 
                 21.3 
                 19.2 
               
               
                 Lung 
                 100.0 
                 95.3 
               
               
                 Thymus 
                 6.9 
                 1.2 
               
               
                 Kidney 
                 8.8 
                 3.8 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag1395, Run 140112952    
               
               
                   Column B - Rel. Exp. (%) Ag1395, Run 142259379    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XK 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 5 Islet 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 97457_Patient-02go_adipose 
                 15.1 
               
               
                   
                 97476_Patient-07sk_skeletal muscle 
                 0.0 
               
               
                   
                 97477_Patient-07ut_uterus 
                 3.9 
               
               
                   
                 97478_Patient-07pl_placenta 
                 0.0 
               
               
                   
                 99167_Bayer Patient 1 
                 62.0 
               
               
                   
                 97482_Patient-08ut_uterus 
                 8.2 
               
               
                   
                 97483_Patient-08pl_placenta 
                 0.0 
               
               
                   
                 97486_Patient-09sk_skeletal muscle 
                 0.0 
               
               
                   
                 97487_Patient-09ut_uterus 
                 3.7 
               
               
                   
                 97488_Patient-09pl_placenta 
                 0.0 
               
               
                   
                 97492_Patient-10ut_uterus 
                 9.7 
               
               
                   
                 97493_Patient-10pl_placenta 
                 0.0 
               
               
                   
                 97495_Patient-11go_adipose 
                 17.2 
               
               
                   
                 97496_Patient-11sk_skeletal muscle 
                 0.0 
               
               
                   
                 97497_Patient-11ut_uterus 
                 14.7 
               
               
                   
                 97498_Patient-11pl_placenta 
                 0.0 
               
               
                   
                 97500_Patient-12go_adipose 
                 19.6 
               
               
                   
                 97501_Patient-12sk_skeletal muscle 
                 0.0 
               
               
                   
                 97502_Patient-12ut_uterus 
                 27.0 
               
               
                   
                 97503_Patient-12pl_placenta 
                 1.6 
               
               
                   
                 94721_Donor 2 U - A_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94722_Donor 2 U - B_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94723_Donor 2 U - C_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94709_Donor 2 AM - A_adipose 
                 0.0 
               
               
                   
                 94710_Donor 2 AM - B_adipose 
                 0.0 
               
               
                   
                 94711_Donor 2 AM - C_adipose 
                 0.0 
               
               
                   
                 94712_Donor 2 AD - A_adipose 
                 0.0 
               
               
                   
                 94713_Donor 2 AD - B_adipose 
                 0.0 
               
               
                   
                 94714_Donor 2 AD - C_adipose 
                 0.0 
               
               
                   
                 94742_Donor 3 U - A_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94743_Donor 3 U - B_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94730_Donor 3 AM - A_adipose 
                 0.0 
               
               
                   
                 94731_Donor 3 AM - B_adipose 
                 0.0 
               
               
                   
                 94732_Donor 3 AM - C_adipose 
                 0.0 
               
               
                   
                 94733_Donor 3 AD - A_adipose 
                 0.0 
               
               
                   
                 94734_Donor 3 AD - B_adipose 
                 0.0 
               
               
                   
                 94735_Donor 3 AD - C_adipose 
                 0.0 
               
               
                   
                 77138_Liver_HepG2 untreated 
                 0.0 
               
               
                   
                 73556_Heart_Cardiac stromal cells (primary) 
                 3.2 
               
               
                   
                 81735_Small Intestine 
                 5.4 
               
               
                   
                 72409_Kidney_Proximal Convoluted Tubule 
                 28.1 
               
               
                   
                 82685_Small intestine_Duodenum 
                 0.0 
               
               
                   
                 90650_Adrenal_Adrenocortical adenoma 
                 0.0 
               
               
                   
                 72410_Kidney_HRCE 
                 42.6 
               
               
                   
                 72411_Kidney_HRE 
                 100.0 
               
               
                   
                 73139_Uterus_Uterine smooth muscle cells 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1395, Run 267095054    
               
            
           
         
       
     
      Ardais Breast1.0 Summary: Ag1395/Ag8392 Highest expression of this gene was detected in abreast cancer sample (CTs=25-27). Moderate to high levels of expression of this gene were seen in normal and cancer samples from breast. Expression of this gene was higher in a number of cancer samples. Therefore, therapeutic modulation of this gene, expressed protein and/or use of antibodies or small molecule targeting this gene or gene product is useful in the treatment of breast cancer.  
      Ardais Panel 1.1 Summary: Ag1395/Ag8392 Highest expression of this gene was detected in normal adjacent lung tissue (CTs=29-30). Moderate to high levels of expression of this gene were seen in normal and cancer samples from lung. Expression of this gene was higher in a number of normal adjacent tissues. Therefore, therapeutic modulation of this gene, expressed protein and/or use of antibodies or small molecule targeting this gene or gene product is useful in the treatment of lung cancer.  
      Ardais Prostate 1.0 Summary: Ag1395/Ag8392 Highest expression of this gene was detected in a prostate cancer sample (CTs=25). Moderate to high levels of expression of this gene were seen in normal and cancer samples from prostate. Expression of this gene was higher in a number of prostate cancer samples. Therefore, therapeutic modulation of this gene, expressed protein and/or use of antibodies or small molecule targeting this gene or gene product is useful in the treatment of prostate cancer.  
      General_screening 13  panel_v1.6 Summary: Ag1395 Highest expression of this gene was detected in cerebellum (CT=26). This gene showed a brain preferential expression, with high expression of this gene seen in all the regions of the brain examined including amygdala, cerebellum, hippocampus, cerebral cortex pool, substantia nigra, and thalamus. This gene encodes an UNC5H1 receptor, an ortholog of  Caenorhabditis elegans  UNC5, which is essential for dorsal guidance of pioneer axons and for the movement of cells away from the netrin ligand (Ackerman, S. L. Nature 386: 838-842). The family of Netrin ligands, netrin-1-2-3 and β-netrin, key regulators of neuronal cell migration and axonal guidance bind to the DCC (deleted in colorectal cancer) family and the UNC5 family (UNC5H1, UNC5H2 and UNC5H3). The DCC family of proteins is implicated in axon attraction and those of the UNC5 family in axon repulsion. Mice homozygous for the spontaneous rostral cerebellar malformation mutation (rcm(s)) homolog of UNC-5 exhibit cerebellar and midbrain defects as a result of abnormalities in the postnatal cerebellar neuronal migration. Modulation of the expression of this gene, expressed protein and/or use of antibodies/small molecule targeting this gene or gene product is useful in the treatment of cerbellar malformation and other brain related disorders including Alzheimer&#39;s disease, Parkinson&#39;s disease, epilepsy, multiple sclerosis, schizophrenia and depression.  
      Significant expression of this gene was also seen in a number of cancer cell lines derived from pancreatic, lung, brain, colon, renal, and ovarian cancers. UNC5 receptors have been shown to create cellular states of dependence on their respective ligands by inhibiting apoptosis in the presence of ligand, but inducing apoptosis when unoccupied by ligand. UNC5H proteins are caspase substrates in vitro and caspase cleavage is required for cell death induction (Llambi F. EMBO J 20(11):2715-22). Based on the known role of these genes in cell migration and the expression of this gene cancer tissues and cell lines, including the metastatic cancer cell lines SW620 and SK-N-AS, the most likely mechanism for this gene is to increase the metastatic potential of tumor cells. When induced in endothelial cells, this gene will have a role in tumor induced endo cell migration and cell survival. The two roles might be interrelated as it is known that cells need to resist anoikis to survive during migration. Therefore, modulation of this gene, expressed protein and/or use of antibodies or small molecule targeting this gene or gene product is useful in the treatment of pancreatic, lung, brain, colon, renal, and ovarian cancers.  
      HASS Panel v1.0 Summary: Ag1395 Highest expression of this gene was detected in medullablastoma sample (CT=26.5). Low expression of this gene was also seen in a glioma sample. Therefore, therapeutic modulation of this gene or expressed protein is useful in the treatment of glioma and medulloblastoma.  
      In addition, significant expression of this gene was seen in samples from breast cancer MCF7 and pancreatic cancer CaPaN cell lines. The expression of this gene was not significantly changed by oxygen deprivation, acidic or a serum starved environment in the these two cell lines in this panel.  
      Panel 2D Summary: Ag1395 Highest expression of this gene was detected in a gastric cancer and metastatic breast cancer samples (CTs=29-31). Moderate to low levels of expression of this gene were also seen in number of kidney, breast and gastric cancer samples. Therefore, expression of this gene is useful as a marker to detect the presence of these cancers and therapeutic modulation of this gene, expressed protein and/or use of antibodies or small molecule is useful in the treatment of breast, kidney and gastric cancers.  
      Panel 3D Summary: Ag1395 Highest expression of this gene was detected in a lung cancer cell line (CT=28.8). Moderate to low levels of expression of this gene were detected in cancer cell lines derived from metastatic neuroblastoma, glioblastoma, lung, gastric, colon, lymphoma, renal, pancreatic, breast and tongue cancers. Therefore, therapeutic modulation of this gene and/or expressed protein is useful in the treatment of these cancers.  
      Panel 4D Summary: Ag1395 Highest expression of this gene was detected in lung and PMA/ionomycin activated LAK cells (CTs=31). Moderate to low levels of expression of this gene were also seen in resting LAK cells, resting and activated dendritic cells, monocytes and macrophages, activated keratinocytes, liver cirrhosis and normal colon tissues. Expression of this gene in monocytes, LAK, macrophage and dendritic cells demonstrates that the expressed protein is important in differentiation and activation of these cell types. Therefore, regulating the expression of this gene or expressed protein will alter the types and levels of monocytic cells regulated by cytokine and chemokine production and T cell activation. Therapeutics modulation of this gene, encoded protein and/or use of antibodies or small molecule targeting this gene or gene product is useful in the treatment of liver cirrhosis, asthma, emphysema, inflammatory bowel disease, arthritis and psoriasis.  
      Panel 5 Islet Summary: Ag1395 Expression of this gene was limited to the kidney on this panel (CT=33.9). Therefore, modulation of this gene and/or expressed protein is useful in the treatment of kidney related disorders including systemic lupus erythematosus and glomerulonephritis.  
      Y. CG53944-02: Novel Membrane Protein  
      Expression of full-length physical clone CG53944-02 was assessed using the primer-probe sets Ag2639, Ag2640, and Ag2641, described in Tables YA, YB, and YC. Results of the RTQ-PCR runs are shown in Tables YD, YE, YF and YG.  
               TABLE YA                          Probe Name Ag2639                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-ctcatcctcagcaacaacca-3′   20   406   1372                   Probe   TET-5′-cctggatgattgtgccgagacact-3′-   24   450   1373           TAMRA               Reverse   5′-taggagaggtcgaggtcctc-3′   20   475   1374                  
 
     
       
         
           
               
             
               
                 TABLE YB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag2640 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-ctcatcctcagcaacaacca-3′ 
                 20 
                 406 
                 1375 
                   
               
               
                   
               
               
                 Probe  
                 TET-5′-cctggatgattgtgccgagacact-3′- 
                 24 
                 450 
                 1376 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-tgtaggagaggtcgaggtcc-3′ 
                 20 
                 477 
                 1377 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE YC 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag2641 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-ctcatcctcagcaacaacca-3′ 
                 20 
                 406 
                 1378 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-cctggatgattgtgccgagacact-3′- 
                 24 
                 450 
                 1379 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-tgtaggagaggtcgaggtcc-3′ 
                 20 
                 477 
                 1380 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE YD 
               
             
            
               
                   
               
               
                   
               
               
                 CNS_neurodegeneration_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 AD 1 Hippo 
                 55.5 
               
               
                   
                 AD 2 Hippo 
                 79.0 
               
               
                   
                 AD 3 Hippo 
                 35.8 
               
               
                   
                 AD 4 Hippo 
                 63.3 
               
               
                   
                 AD 5 hippo 
                 85.3 
               
               
                   
                 AD 6 Hippo 
                 54.7 
               
               
                   
                 Control 2 Hippo 
                 65.1 
               
               
                   
                 Control 4 Hippo 
                 50.7 
               
               
                   
                 Control (Path) 3 Hippo 
                 41.8 
               
               
                   
                 AD 1 Temporal Ctx 
                 37.4 
               
               
                   
                 AD 2 Temporal Ctx 
                 68.8 
               
               
                   
                 AD 3 Temporal Ctx 
                 52.5 
               
               
                   
                 AD 4 Temporal Ctx 
                 45.7 
               
               
                   
                 AD 5 Inf Temporal Ctx 
                 63.7 
               
               
                   
                 AD 5 Sup Temporal Ctx 
                 49.3 
               
               
                   
                 AD 6 Inf Temporal Ctx 
                 58.6 
               
               
                   
                 AD 6 Sup Temporal Ctx 
                 49.0 
               
               
                   
                 Control 1 Temporal Ctx 
                 59.0 
               
               
                   
                 Control 2 Temporal Ctx 
                 100.0 
               
               
                   
                 Control 3 Temporal Ctx 
                 71.2 
               
               
                   
                 Control 4 Temporal Ctx 
                 67.8 
               
               
                   
                 Control (Path) 1 Temporal Ctx 
                 57.8 
               
               
                   
                 Control (Path) 2 Temporal Ctx 
                 45.4 
               
               
                   
                 Control (Path) 3 Temporal Ctx 
                 57.8 
               
               
                   
                 Control (Path) 4 Temporal Ctx 
                 75.3 
               
               
                   
                 AD 1 Occipital Ctx 
                 27.5 
               
               
                   
                 AD 2 Occipital Ctx (Missing) 
                 2.0 
               
               
                   
                 AD 3 Occipital Ctx 
                 36.3 
               
               
                   
                 AD 4 Occipital Ctx 
                 32.5 
               
               
                   
                 AD 5 Occipital Ctx 
                 37.4 
               
               
                   
                 AD 6 Occipital Ctx 
                 49.7 
               
               
                   
                 Control 1 Occipital Ctx 
                 55.1 
               
               
                   
                 Control 2 Occipital Ctx 
                 92.0 
               
               
                   
                 Control 3 Occipital Ctx 
                 57.8 
               
               
                   
                 Control 4 Occipital Ctx 
                 46.3 
               
               
                   
                 Control (Path) 1 Occipital Ctx 
                 69.7 
               
               
                   
                 Control (Path) 2 Occipital Ctx 
                 63.3 
               
               
                   
                 Control (Path) 3 Occipital Ctx 
                 51.8 
               
               
                   
                 Control (Path) 4 Occipital Ctx 
                 82.9 
               
               
                   
                 Control 1 Parietal Ctx 
                 39.5 
               
               
                   
                 Control 2 Parietal Ctx 
                 54.3 
               
               
                   
                 Control 3 Parietal Ctx 
                 67.4 
               
               
                   
                 Control (Path) 1 Parietal Ctx 
                 84.7 
               
               
                   
                 Control (Path) 2 Parietal Ctx 
                 56.6 
               
               
                   
                 Control (Path) 3 Parietal Ctx 
                 47.0 
               
               
                   
                 Control (Path) 4 Parietal Ctx 
                 79.6 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2641, Run 206954924    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE YE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 17.1 
               
               
                   
                 Pancreas 
                 2.7 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 3.9 
               
               
                   
                 Adrenal gland 
                 4.4 
               
               
                   
                 Thyroid 
                 5.9 
               
               
                   
                 Salivary gland 
                 7.0 
               
               
                   
                 Pituitary gland 
                 16.5 
               
               
                   
                 Brain (fetal) 
                 12.4 
               
               
                   
                 Brain (whole) 
                 12.4 
               
               
                   
                 Brain (amygdala) 
                 31.0 
               
               
                   
                 Brain (cerebellum) 
                 11.2 
               
               
                   
                 Brain (hippocampus) 
                 100.0 
               
               
                   
                 Brain (substantia nigra) 
                 3.6 
               
               
                   
                 Brain (thalamus) 
                 19.3 
               
               
                   
                 Cerebral Cortex 
                 24.1 
               
               
                   
                 Spinal cord 
                 5.9 
               
               
                   
                 glio/astro U87-MG 
                 12.9 
               
               
                   
                 glio/astro U-118-MG 
                 17.1 
               
               
                   
                 astrocytoma SW1783 
                 10.4 
               
               
                   
                 neuro*; met SK-N-AS 
                 27.7 
               
               
                   
                 astrocytoma SF-539 
                 9.9 
               
               
                   
                 astrocytoma SNB-75 
                 19.9 
               
               
                   
                 glioma SNB-19 
                 11.2 
               
               
                   
                 glioma U251 
                 2.2 
               
               
                   
                 glioma SF-295 
                 11.2 
               
               
                   
                 Heart (fetal) 
                 5.4 
               
               
                   
                 Heart 
                 1.0 
               
               
                   
                 Skeletal muscle (fetal) 
                 15.3 
               
               
                   
                 Skeletal muscle 
                 1.5 
               
               
                   
                 Bone marrow 
                 1.2 
               
               
                   
                 Thymus 
                 2.2 
               
               
                   
                 Spleen 
                 7.4 
               
               
                   
                 Lymph node 
                 2.4 
               
               
                   
                 Colorectal 
                 1.5 
               
               
                   
                 Stomach 
                 7.1 
               
               
                   
                 Small intestine 
                 12.8 
               
               
                   
                 Colon ca. SW480 
                 7.4 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 3.0 
               
               
                   
                 Colon ca. HT29 
                 2.5 
               
               
                   
                 Colon ca. HCT-116 
                 5.9 
               
               
                   
                 Colon ca. CaCo-2 
                 5.0 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 6.7 
               
               
                   
                 Colon ca. HCC-2998 
                 23.2 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 9.9 
               
               
                   
                 Bladder 
                 1.2 
               
               
                   
                 Trachea 
                 12.6 
               
               
                   
                 Kidney 
                 1.2 
               
               
                   
                 Kidney (fetal) 
                 4.0 
               
               
                   
                 Renal ca. 786-0 
                 1.9 
               
               
                   
                 Renal ca. A498 
                 15.2 
               
               
                   
                 Renal ca. RXF 393 
                 1.4 
               
               
                   
                 Renal ca. ACHN 
                 2.9 
               
               
                   
                 Renal ca. UO-31 
                 3.4 
               
               
                   
                 Renal ca. TK-10 
                 1.6 
               
               
                   
                 Liver 
                 2.9 
               
               
                   
                 Liver (fetal) 
                 2.3 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 5.3 
               
               
                   
                 Lung 
                 7.3 
               
               
                   
                 Lung (fetal) 
                 5.1 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 1.5 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 9.2 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 7.3 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 3.3 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 18.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 7.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 7.3 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 4.4 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 4.4 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.6 
               
               
                   
                 Mammary gland 
                 9.5 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 6.3 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 48.3 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.7 
               
               
                   
                 Breast ca. BT-549 
                 13.9 
               
               
                   
                 Breast ca. MDA-N 
                 8.5 
               
               
                   
                 Ovary 
                 10.4 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 7.2 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 1.7 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 3.6 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 3.7 
               
               
                   
                 Ovarian ca. IGROV-1 
                 2.5 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 3.5 
               
               
                   
                 Uterus 
                 14.6 
               
               
                   
                 Placenta 
                 3.4 
               
               
                   
                 Prostate 
                 5.7 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 5.6 
               
               
                   
                 Testis 
                 10.2 
               
               
                   
                 Melanoma Hs688(A).T 
                 5.3 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 3.1 
               
               
                   
                 Melanoma UACC-62 
                 2.0 
               
               
                   
                 Melanoma M14 
                 2.8 
               
               
                   
                 Melanoma LOX IMVI 
                 15.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 3.1 
               
               
                   
                 Adipose 
                 2.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2639, Run 157543474    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE YF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 43.5 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 30.4 
               
               
                   
                 CC Margin (ODO3866) 
                 18.8 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 9.1 
               
               
                   
                 CC Margin (ODO3868) 
                 3.6 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 22.8 
               
               
                   
                 CC Margin (ODO3920) 
                 11.0 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 40.1 
               
               
                   
                 CC Margin (ODO3921) 
                 28.5 
               
               
                   
                 CC from Partial Hepatectomy (ODO4309) Mets 
                 5.8 
               
               
                   
                 Liver Margin (ODO4309) 
                 14.2 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 15.8 
               
               
                   
                 Lung Margin (OD04451-02) 
                 7.3 
               
               
                   
                 Normal Prostate 6546-1 
                 17.0 
               
               
                   
                 Prostate Cancer (OD04410) 
                 53.2 
               
               
                   
                 Prostate Margin (OD04410) 
                 35.4 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 31.4 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 36.9 
               
               
                   
                 Normal Lung 061010 
                 29.1 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 8.7 
               
               
                   
                 Muscle Margin (ODO4286) 
                 25.5 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 44.1 
               
               
                   
                 Lung Margin (OD03126) 
                 23.3 
               
               
                   
                 Lung Cancer (OD04404) 
                 33.2 
               
               
                   
                 Lung Margin (OD04404) 
                 15.4 
               
               
                   
                 Lung Cancer (OD04565) 
                 15.1 
               
               
                   
                 Lung Margin (OD04565) 
                 6.0 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 14.8 
               
               
                   
                 Lung Margin (OD04237-02) 
                 15.6 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 13.5 
               
               
                   
                 Liver Margin (ODO4310) 
                 17.6 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 41.8 
               
               
                   
                 Lung Margin (OD04321) 
                 28.3 
               
               
                   
                 Normal Kidney 
                 43.2 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 45.1 
               
               
                   
                 Kidney Margin (OD04338) 
                 53.2 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 33.0 
               
               
                   
                 Kidney Margin (OD04339) 
                 45.1 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 15.3 
               
               
                   
                 Kidney Margin (OD04340) 
                 36.3 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 17.9 
               
               
                   
                 Kidney Margin (OD04348) 
                 26.2 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 42.9 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 15.3 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 20.6 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 24.5 
               
               
                   
                 Kidney Cancer 8120607 
                 44.1 
               
               
                   
                 Kidney Margin 8120608 
                 34.4 
               
               
                   
                 Kidney Cancer 8120613 
                 39.0 
               
               
                   
                 Kidney Margin 8120614 
                 39.8 
               
               
                   
                 Kidney Cancer 9010320 
                 24.8 
               
               
                   
                 Kidney Margin 9010321 
                 41.5 
               
               
                   
                 Normal Uterus 
                 12.7 
               
               
                   
                 Uterus Cancer 064011 
                 39.8 
               
               
                   
                 Normal Thyroid 
                 23.3 
               
               
                   
                 Thyroid Cancer 064010 
                 21.3 
               
               
                   
                 Thyroid Cancer A302152 
                 11.3 
               
               
                   
                 Thyroid Margin A302153 
                 30.6 
               
               
                   
                 Normal Breast 
                 45.1 
               
               
                   
                 Breast Cancer (OD04566) 
                 16.6 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 81.8 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 100.0 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 72.7 
               
               
                   
                 Breast Cancer 064006 
                 16.3 
               
               
                   
                 Breast Cancer 1024 
                 44.8 
               
               
                   
                 Breast Cancer 9100266 
                 28.1 
               
               
                   
                 Breast Margin 9100265 
                 13.2 
               
               
                   
                 Breast Cancer A209073 
                 44.1 
               
               
                   
                 Breast Margin A209073 
                 24.1 
               
               
                   
                 Normal Liver 
                 13.7 
               
               
                   
                 Liver Cancer 064003 
                 15.1 
               
               
                   
                 Liver Cancer 1025 
                 14.3 
               
               
                   
                 Liver Cancer 1026 
                 23.2 
               
               
                   
                 Liver Cancer 6004-T 
                 16.2 
               
               
                   
                 Liver Tissue 6004-N 
                 7.2 
               
               
                   
                 Liver Cancer 6005-T 
                 36.9 
               
               
                   
                 Liver Tissue 6005-N 
                 10.8 
               
               
                   
                 Normal Bladder 
                 23.7 
               
               
                   
                 Bladder Cancer 1023 
                 19.9 
               
               
                   
                 Bladder Cancer A302173 
                 12.4 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 38.2 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 11.8 
               
               
                   
                 Normal Ovary 
                 38.2 
               
               
                   
                 Ovarian Cancer 064008 
                 59.9 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 38.7 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 9.9 
               
               
                   
                 Normal Stomach 
                 18.9 
               
               
                   
                 Gastric Cancer 9060358 
                 5.2 
               
               
                   
                 Stomach Margin 9060359 
                 25.5 
               
               
                   
                 Gastric Cancer 9060395 
                 28.5 
               
               
                   
                 Stomach Margin 9060394 
                 17.0 
               
               
                   
                 Gastric Cancer 9060397 
                 49.7 
               
               
                   
                 Stomach Margin 9060396 
                 22.8 
               
               
                   
                 Gastric Cancer 064005 
                 18.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2640, Run 157543604    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE YG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 72.7 
               
               
                   
                 Secondary Th2 act 
                 75.3 
               
               
                   
                 Secondary Tr1 act 
                 52.9 
               
               
                   
                 Secondary Th1 rest 
                 36.6 
               
               
                   
                 Secondary Th2 rest 
                 45.7 
               
               
                   
                 Secondary Tr1 rest 
                 57.0 
               
               
                   
                 Primary Th1 act 
                 34.9 
               
               
                   
                 Primary Th2 act 
                 31.6 
               
               
                   
                 Primary Tr1 act 
                 32.5 
               
               
                   
                 Primary Th1 rest 
                 90.8 
               
               
                   
                 Primary Th2 rest 
                 50.3 
               
               
                   
                 Primary Tr1 rest 
                 25.9 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 79.6 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 53.6 
               
               
                   
                 CD8 lymphocyte act 
                 49.3 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 78.5 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 14.0 
               
               
                   
                 CD4 lymphocyte none 
                 25.3 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 26.1 
               
               
                   
                 LAK cells rest 
                 26.1 
               
               
                   
                 LAK cells IL-2 
                 40.1 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 47.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 49.7 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 49.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 14.8 
               
               
                   
                 NK Cells IL-2 rest 
                 38.7 
               
               
                   
                 Two Way MLR 3 day 
                 58.2 
               
               
                   
                 Two Way MLR 5 day 
                 19.8 
               
               
                   
                 Two Way MLR 7 day 
                 12.9 
               
               
                   
                 PBMC rest 
                 23.2 
               
               
                   
                 PBMC PWM 
                 89.5 
               
               
                   
                 PBMC PHA-L 
                 35.4 
               
               
                   
                 Ramos (B cell) none 
                 24.1 
               
               
                   
                 Ramos (B cell) ionomycin 
                 93.3 
               
               
                   
                 B lymphocytes PWM 
                 40.6 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 14.8 
               
               
                   
                 EOL-1 dbcAMP 
                 100.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 81.2 
               
               
                   
                 Dendritic cells none 
                 5.5 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 6.0 
               
               
                   
                 Monocytes rest 
                 3.1 
               
               
                   
                 Monocytes LPS 
                 4.6 
               
               
                   
                 Macrophages rest 
                 11.0 
               
               
                   
                 Macrophages LPS 
                 1.6 
               
               
                   
                 HUVEC none 
                 63.7 
               
               
                   
                 HUVEC starved 
                 48.6 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 96.6 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 51.4 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 93.3 
               
               
                   
                 HUVEC IL-11 
                 57.4 
               
               
                   
                 Lung Microvascular EC none 
                 87.7 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 82.9 
               
               
                   
                 Microvascular Dermal EC none 
                 71.2 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 43.5 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 95.9 
               
               
                   
                 Small airway epithelium none 
                 25.7 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 82.4 
               
               
                   
                 Coronery artery SMC rest 
                 53.6 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 81.2 
               
               
                   
                 Astrocytes rest 
                 57.8 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 41.5 
               
               
                   
                 KU-812 (Basophil) rest 
                 25.7 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 30.8 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 54.3 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 69.3 
               
               
                   
                 Liver cirrhosis 
                 23.3 
               
               
                   
                 Lupus kidney 
                 2.9 
               
               
                   
                 NCI-H292 none 
                 36.1 
               
               
                   
                 NCI-H292 IL-4 
                 67.8 
               
               
                   
                 NCI-H292 IL-9 
                 62.0 
               
               
                   
                 NCI-H292 IL-13 
                 90.1 
               
               
                   
                 NCI-H292 IFN gamma 
                 82.4 
               
               
                   
                 HPAEC none 
                 49.3 
               
               
                   
                 HPAEC TNF alpha + IL-1beta 
                 45.7 
               
               
                   
                 Lung fibroblast none 
                 44.8 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 35.6 
               
               
                   
                 Lung fibroblast IL-4 
                 69.3 
               
               
                   
                 Lung fibroblast IL-9 
                 43.8 
               
               
                   
                 Lung fibroblast IL-13 
                 45.1 
               
               
                   
                 Lung fibroblast IFN gamma 
                 52.5 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 66.9 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 54.3 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 71.2 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 84.1 
               
               
                   
                 Dermal fibroblast IL-4 
                 58.2 
               
               
                   
                 IBD Colitis 2 
                 3.1 
               
               
                   
                 IBD Crohn&#39;s 
                 2.6 
               
               
                   
                 Colon 
                 77.9 
               
               
                   
                 Lung 
                 35.1 
               
               
                   
                 Thymus 
                 41.2 
               
               
                   
                 Kidney 
                 23.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2641, Run 157543823    
               
            
           
         
       
     
      CNS_neurodegeneration_v1.0 Summary: Ag2641 This panel confirmed the expression of this gene at low levels in the brain in an independent group of individuals. This gene was found to be down-regulated in the temporal cortex of Alzheimer&#39;s disease patients patients when compared with non-demented controls (p=0.0003 when analyzed by Ancova, estimate of total cDNA loaded per well used asa covariate). Therefore, up-regulation of this gene or its protein product, or treatment with specific agonists for this receptor is of use in reversing the dementia, memory loss, and neuronal death associated with this disease.  
      Panel 1.3D Summary: Ag2639 Highest expression was seen in the hippocampus (CT=26.3). In addition, high to moderate levels of expression were seen in all regions of the CNS examined, including amygdala, hippocampus, substantia nigra, thalamus, and hypothalamus. This expression shows that therapeutic modulation of the expression or function of this gene is useful in the treatment of neurologic disorders, such as Alzheimer&#39;s disease, Parkinson&#39;s disease, schizophrenia, multiple sclerosis, stroke and epilepsy.  
      Panel 2D Summary: Ag2640 Highest expression was seen in a breast metastasis sample (CT=28.4), with moderate expression throughout this panel. This widespread expression demonstrates that this gene or gene product plays in cell growth and/or proliferation.  
      Panel 4D Summary: Ag2641 Highest expression was seen in an eosinophil cell line (CT=30). This gene was also expressed at moderate levels in a wide range of cell types of significance in the immune response in health and disease. These cells included members of the T-cell, B-cell, endothelial cell, macrophage/monocyte, and peripheral blood mononuclear cell family, as well as epithelial and fibroblast cell types from lung and skin, and normal tissues represented by colon, lung, thymus and kidney. This ubiquitous pattern of expression demonstrates that this gene product is involved in homeostatic processes for these and other cell types and tissues. This pattern was in agreement with the expression profile in Panel 2D and also shows a role for the gene or gene product in cell survival and proliferation. Therefore, modulation of the gene or its protein product with a functional therapeutic is useful for the alteration of functions associated with these cell types and for the improvement of the symptoms of patients suffering from autoimmune and inflammatory diseases such as asthma, allergies, inflammatory bowel disease, lupus erythematosus, psoriasis, rheumatoid arthritis, and osteoarthritis.  
      Z. CG5430804: Serpin  
      Expression of full-length physical clone CG54308-04 was assessed using the primer-probe sets Ag548 and Ag7880, described in Tables ZA and ZB. Results of the RTQ-PCR runs are shown in Tables ZC, ZD, ZE, ZF, and ZG.  
               TABLE ZA                          Probe Name Ag548                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-tggagcagctcagaaaacatgt-3′   22   910   1381                   Probe   TET-5′-agaatcggtggtcctgtccttcccc-3′-   25   936   1382           TAMRA               Reverse   5′-catagctgtcttccagggtgaac-3′   23   963   1383                  
 
     
       
         
           
               
             
               
                 TABLE ZB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag7880 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-tccagaggctctgtcgtttt-3′ 
                 20 
                 277 
                 1384 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-tccagagagctgtcagccagcacttt-3′- 
                 26 
                 241 
                 1385 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-gaacctgacccttgtctgaaa-3′ 
                 21 
                 208 
                 1386 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ZC 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.7 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 63.3 
               
               
                   
                 HUVEC 
                 0.0 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 18.3 
               
               
                   
                 Melanoma (met) SK-MEL-5 
                 0.0 
               
               
                   
                 Testis 
                 7.9 
               
               
                   
                 Prostate ca. (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate ca. DU145 
                 0.0 
               
               
                   
                 Prostate pool 
                 0.0 
               
               
                   
                 Uterus pool 
                 100.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 8.1 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
               
               
                   
                 Ovary 
                 0.0 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
               
               
                   
                 Breast ca. T47D 
                 0.0 
               
               
                   
                 Breast pool 
                 0.0 
               
               
                   
                 Trachea 
                 12.1 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Fetal Lung 
                 0.0 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 0.0 
               
               
                   
                 Lung ca. NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. HOP-62 
                 0.0 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
               
               
                   
                 Lung ca. DMS-114 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 0.0 
               
               
                   
                 Kidney pool 
                 0.1 
               
               
                   
                 Fetal Kidney 
                 0.0 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Bladder 
                 0.0 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.0 
               
               
                   
                 Stomach 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca. (SW480 met) SW620 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon cancer tissue 
                 0.0 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon 
                 0.0 
               
               
                   
                 Small Intestine 
                 0.0 
               
               
                   
                 Fetal Heart 
                 0.0 
               
               
                   
                 Heart 
                 0.0 
               
               
                   
                 Lymph Node pool 1 
                 0.0 
               
               
                   
                 Lymph Node pool 2 
                 0.0 
               
               
                   
                 Fetal Skeletal Muscle 
                 6.7 
               
               
                   
                 Skeletal Muscle pool 
                 0.0 
               
               
                   
                 Skeletal Muscle 
                 0.0 
               
               
                   
                 Spleen 
                 0.0 
               
               
                   
                 Thymus 
                 7.5 
               
               
                   
                 CNS cancer (glio/astro) SF-268 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) T98G 
                 0.0 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.0 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 0.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.0 
               
               
                   
                 Brain (Amygdala) 
                 0.0 
               
               
                   
                 Brain (Cerebellum) 
                 0.0 
               
               
                   
                 Brain (Fetal) 
                 0.0 
               
               
                   
                 Brain (Hippocampus) 
                 0.0 
               
               
                   
                 Cerebral Cortex pool 
                 0.0 
               
               
                   
                 Brain (Substantia nigra) 
                 0.0 
               
               
                   
                 Brain (Thalamus) 
                 0.0 
               
               
                   
                 Brain (Whole) 
                 0.0 
               
               
                   
                 Spinal Cord 
                 0.0 
               
               
                   
                 Adrenal Gland 
                 0.0 
               
               
                   
                 Pituitary Gland 
                 0.0 
               
               
                   
                 Salivary Gland 
                 0.0 
               
               
                   
                 Thyroid 
                 0.0 
               
               
                   
                 Pancreatic ca. PANC-1 
                 0.0 
               
               
                   
                 Pancreas pool 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag7880, Run 319066287    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ZD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.2 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Endothelial cells 
                 0.0 
               
               
                   
                 Heart (Fetal) 
                 0.0 
               
               
                   
                 Pancreas 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
               
               
                   
                 Adrenal Gland 
                 0.0 
               
               
                   
                 Thyroid 
                 0.0 
               
               
                   
                 Salivary gland 
                 0.0 
               
               
                   
                 Pituitary gland 
                 0.0 
               
               
                   
                 Brain (fetal) 
                 0.0 
               
               
                   
                 Brain (whole) 
                 0.0 
               
               
                   
                 Brain (amygdala) 
                 0.0 
               
               
                   
                 Brain (cerebellum) 
                 0.0 
               
               
                   
                 Brain (hippocampus) 
                 0.0 
               
               
                   
                 Brain (thalamus) 
                 0.0 
               
               
                   
                 Cerebral Cortex 
                 0.0 
               
               
                   
                 Spinal cord 
                 0.0 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.0 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.0 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 0.0 
               
               
                   
                 glioma SNB-19 
                 0.0 
               
               
                   
                 glioma U251 
                 0.0 
               
               
                   
                 glioma SF-295 
                 0.0 
               
               
                   
                 Heart 
                 0.0 
               
               
                   
                 Skeletal Muscle 
                 0.0 
               
               
                   
                 Bone marrow 
                 0.0 
               
               
                   
                 Thymus 
                 100.0 
               
               
                   
                 Spleen 
                 0.0 
               
               
                   
                 Lymph node 
                 0.0 
               
               
                   
                 Colorectal Tissue 
                 0.0 
               
               
                   
                 Stomach 
                 0.0 
               
               
                   
                 Small intestine 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* SW620 (SW480 met) 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon ca. Tissue (ODO3866) 
                 0.0 
               
               
                   
                 Colon ca. HCC-2998 
                 0.0 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.0 
               
               
                   
                 Bladder 
                 0.0 
               
               
                   
                 Trachea 
                 0.0 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                 Kidney (fetal) 
                 0.0 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Liver (fetal) 
                 0.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Lung (fetal) 
                 0.0 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.0 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
               
               
                   
                 Mammary gland 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Ovary 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 0.0 
               
               
                   
                 Uterus 
                 0.0 
               
               
                   
                 Placenta 
                 0.0 
               
               
                   
                 Prostate 
                 0.0 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Testis 
                 2.6 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
               
               
                   
                 Melanoma M14 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag548, Run 122671023    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ZE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 0.0 
               
               
                   
                 Pancreas 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
               
               
                   
                 Adrenal gland 
                 17.4 
               
               
                   
                 Thyroid 
                 0.0 
               
               
                   
                 Salivary gland 
                 0.0 
               
               
                   
                 Pituitary gland 
                 0.0 
               
               
                   
                 Brain (fetal) 
                 0.0 
               
               
                   
                 Brain (whole) 
                 21.3 
               
               
                   
                 Brain (amygdala) 
                 0.0 
               
               
                   
                 Brain (cerebellum) 
                 0.0 
               
               
                   
                 Brain (hippocampus) 
                 0.0 
               
               
                   
                 Brain (substantia nigra) 
                 0.0 
               
               
                   
                 Brain (thalamus) 
                 0.0 
               
               
                   
                 Cerebral Cortex 
                 0.0 
               
               
                   
                 Spinal cord 
                 0.0 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.0 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.0 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 0.0 
               
               
                   
                 glioma SNB-19 
                 0.0 
               
               
                   
                 glioma U251 
                 0.0 
               
               
                   
                 glioma SF-295 
                 0.0 
               
               
                   
                 Heart (fetal) 
                 0.0 
               
               
                   
                 Heart 
                 0.0 
               
               
                   
                 Skeletal muscle (fetal) 
                 2.1 
               
               
                   
                 Skeletal muscle 
                 0.0 
               
               
                   
                 Bone marrow 
                 0.0 
               
               
                   
                 Thymus 
                 100.0 
               
               
                   
                 Spleen 
                 0.0 
               
               
                   
                 Lymph node 
                 0.0 
               
               
                   
                 Colorectal 
                 9.7 
               
               
                   
                 Stomach 
                 0.0 
               
               
                   
                 Small intestine 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 0.0 
               
               
                   
                 Colon ca. HCC-2998 
                 0.0 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.0 
               
               
                   
                 Bladder 
                 0.0 
               
               
                   
                 Trachea 
                 0.0 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                 Kidney (fetal) 
                 0.0 
               
               
                   
                 Renal ca. 786-0 
                 2.9 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Liver (fetal) 
                 0.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
               
               
                   
                 Lung 
                 11.3 
               
               
                   
                 Lung (fetal) 
                 0.0 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.0 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 14.0 
               
               
                   
                 Mammary gland 
                 23.7 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 11.5 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 22.8 
               
               
                   
                 Ovary 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.0 
               
               
                   
                 Uterus 
                 0.0 
               
               
                   
                 Placenta 
                 0.0 
               
               
                   
                 Prostate 
                 5.3 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 12.8 
               
               
                   
                 Testis 
                 22.1 
               
               
                   
                 Melanoma Hs688(A).T 
                 11.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 10.6 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
               
               
                   
                 Melanoma M14 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
               
               
                   
                 Adipose 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag548, Run 167658585    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ZF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Normal Colon 
                 0.0 
                 0.0 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 5.6 
                 4.6 
               
               
                   
                 CC Margin (ODO3866) 
                 3.3 
                 3.1 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 0.0 
                 0.0 
               
               
                   
                 CC Margin (ODO3868) 
                 0.0 
                 0.0 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 0.0 
                 0.0 
               
               
                   
                 CC Margin (ODO3920) 
                 0.0 
                 0.0 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 0.0 
                 0.0 
               
               
                   
                 CC Margin (ODO3921) 
                 6.3 
                 0.0 
               
               
                   
                 CC from Partial Hepatectomy 
                 0.0 
                 0.0 
               
               
                   
                 (ODO4309) Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 0.0 
                 0.0 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 4.6 
                 2.4 
               
               
                   
                 Lung Margin (OD04451-02) 
                 2.9 
                 0.0 
               
               
                   
                 Normal Prostate 6546-1 
                 2.5 
                 6.1 
               
               
                   
                 Prostate Cancer (OD04410) 
                 0.0 
                 0.0 
               
               
                   
                 Prostate Margin (OD04410) 
                 3.1 
                 0.0 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 4.5 
                 0.0 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 0.0 
                 0.0 
               
               
                   
                 Normal Lung 061010 
                 6.6 
                 0.0 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 12.9 
                 3.7 
               
               
                   
                 Muscle Margin (ODO4286) 
                 2.8 
                 0.0 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 2.8 
                 0.0 
               
               
                   
                 Lung Margin (OD03126) 
                 3.0 
                 0.0 
               
               
                   
                 Lung Cancer (OD04404) 
                 0.0 
                 0.0 
               
               
                   
                 Lung Margin (OD04404) 
                 0.0 
                 0.0 
               
               
                   
                 Lung Cancer (OD04565) 
                 17.3 
                 6.1 
               
               
                   
                 Lung Margin (OD04565) 
                 1.4 
                 0.0 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 0.0 
                 0.0 
               
               
                   
                 Lung Margin (OD04237-02) 
                 2.9 
                 0.0 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 5.1 
                 0.0 
               
               
                   
                 Liver Margin (ODO4310) 
                 0.0 
                 2.0 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.0 
                 0.0 
               
               
                   
                 Lung Margin (OD04321) 
                 0.0 
                 0.0 
               
               
                   
                 Normal Kidney 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04338) 
                 0.0 
                 1.0 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04339) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 0.0 
                 2.8 
               
               
                   
                 Kidney Margin (OD04340) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04348) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 4.6 
                 3.8 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.0 
                 4.5 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 0.0 
                 2.3 
               
               
                   
                 Kidney Cancer 8120607 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin 8120608 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Cancer 8120613 
                 1.6 
                 2.6 
               
               
                   
                 Kidney Margin 8120614 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Cancer 9010320 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin 9010321 
                 0.0 
                 0.0 
               
               
                   
                 Normal Uterus 
                 0.0 
                 8.8 
               
               
                   
                 Uterus Cancer 064011 
                 0.0 
                 0.0 
               
               
                   
                 Normal Thyroid 
                 2.8 
                 2.7 
               
               
                   
                 Thyroid Cancer 064010 
                 0.0 
                 4.5 
               
               
                   
                 Thyroid Cancer A302152 
                 1.8 
                 0.0 
               
               
                   
                 Thyroid Margin A302153 
                 0.0 
                 0.0 
               
               
                   
                 Normal Breast 
                 2.5 
                 0.0 
               
               
                   
                 Breast Cancer (OD04566) 
                 2.3 
                 0.0 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 0.0 
                 0.0 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 0.0 
                 0.0 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 0.0 
                 0.0 
               
               
                   
                 Breast Cancer 064006 
                 0.0 
                 0.0 
               
               
                   
                 Breast Cancer 1024 
                 5.8 
                 0.0 
               
               
                   
                 Breast Cancer 9100266 
                 0.0 
                 0.0 
               
               
                   
                 Breast Margin 9100265 
                 0.0 
                 0.0 
               
               
                   
                 Breast Cancer A209073 
                 9.5 
                 0.0 
               
               
                   
                 Breast Margin A209073 
                 0.0 
                 0.0 
               
               
                   
                 Normal Liver 
                 0.0 
                 3.0 
               
               
                   
                 Liver Cancer 064003 
                 0.0 
                 2.7 
               
               
                   
                 Liver Cancer 1025 
                 0.0 
                 0.0 
               
               
                   
                 Liver Cancer 1026 
                 0.0 
                 0.0 
               
               
                   
                 Liver Cancer 6004-T 
                 0.0 
                 0.0 
               
               
                   
                 Liver Tissue 6004-N 
                 8.4 
                 4.5 
               
               
                   
                 Liver Cancer 6005-T 
                 0.0 
                 0.0 
               
               
                   
                 Liver Tissue 6005-N 
                 0.0 
                 0.0 
               
               
                   
                 Normal Bladder 
                 0.0 
                 2.8 
               
               
                   
                 Bladder Cancer 1023 
                 0.0 
                 5.0 
               
               
                   
                 Bladder Cancer A302173 
                 100.0 
                 100.0 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 0.0 
                 0.0 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 0.0 
                 4.4 
               
               
                   
                 Normal Ovary 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian Cancer 064008 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 0.0 
                 0.0 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 0.0 
                 0.0 
               
               
                   
                 Normal Stomach 
                 0.0 
                 0.0 
               
               
                   
                 Gastric Cancer 9060358 
                 0.0 
                 0.0 
               
               
                   
                 Stomach Margin 9060359 
                 0.0 
                 0.0 
               
               
                   
                 Gastric Cancer 9060395 
                 0.0 
                 0.0 
               
               
                   
                 Stomach Margin 9060394 
                 0.0 
                 0.0 
               
               
                   
                 Gastric Cancer 9060397 
                 0.0 
                 0.0 
               
               
                   
                 Stomach Margin 9060396 
                 0.0 
                 0.0 
               
               
                   
                 Gastric Cancer 064005 
                 1.5 
                 6.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag548, Run 145364354    
               
               
                   
                   Column B - Rel. Exp. (%) Ag548, Run 145506152    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ZG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Secondary Th1 act 
                 0.0 
                 3.1 
                 0.0 
               
               
                 Secondary Th2 act 
                 0.0 
                 0.0 
                 4.9 
               
               
                 Secondary Tr1 act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Th1 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 rest 
                 0.0 
                 7.1 
                 0.0 
               
               
                 Primary Th1 act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th2 act 
                 0.0 
                 1.1 
                 0.0 
               
               
                 Primary Tr1 act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th1 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th2 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 rest 
                 0.0 
                 0.0 
                 5.3 
               
               
                 CD45RA CD4 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CD45RO CD4 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CD8 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CD4 lymphocyte none 
                 0.0 
                 0.0 
                 0.0 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 
                 5.8 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-12 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IFN gamma 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-18 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
               
               
                 NK Cells IL-2 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 3 day 
                 0.0 
                 3.3 
                 0.0 
               
               
                 Two Way MLR 5 day 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 7 day 
                 0.0 
                 0.0 
                 0.0 
               
               
                 PBMC rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 PBMC PWM 
                 0.0 
                 0.0 
                 0.0 
               
               
                 PBMC PHA-L 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) none 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
                 0.0 
               
               
                 B lymphocytes PWM 
                 0.0 
                 0.0 
                 0.0 
               
               
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP 
                 0.0 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells none 
                 3.5 
                 0.0 
                 0.0 
               
               
                 Dendritic cells LPS 
                 0.0 
                 0.0 
                 5.4 
               
               
                 Dendritic cells anti-CD40 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Monocytes rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Monocytes LPS 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Macrophages rest 
                 4.5 
                 0.0 
                 0.0 
               
               
                 Macrophages LPS 
                 2.4 
                 8.0 
                 0.0 
               
               
                 HUVEC none 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC starved 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-1beta 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC IFN gamma 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IL4 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-11 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung Microvascular EC none 
                 0.0 
                 2.9 
                 0.0 
               
               
                 Lung Microvascular EC TNFalpha + 
                 0.0 
                 0.0 
                 0.0 
               
               
                 IL-1beta 
               
               
                 Microvascular Dermal EC none 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Microsvasular Dermal EC 
                 0.0 
                 0.0 
                 0.0 
               
               
                 TNFalpha + IL-1beta 
               
               
                 Bronchial epithelium TNFalpha + 
                 6.5 
                 0.0 
                 0.0 
               
               
                 IL1beta 
               
               
                 Small airway epithelium none 
                 13.4 
                 13.6 
                 8.8 
               
               
                 Small airway epithelium TNFalpha + 
                 100.0 
                 73.2 
                 95.9 
               
               
                 IL-1beta 
               
               
                 Coronery artery SMC rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Coronery artery SMC TNFalpha + 
                 0.0 
                 0.0 
                 0.0 
               
               
                 IL-1beta 
               
               
                 Astrocytes rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
                 0.0 
                 5.5 
               
               
                 KU-812 (Basophil) rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) none 
                 0.0 
                 3.4 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) TNFalpha + 
                 4.3 
                 2.4 
                 0.0 
               
               
                 IL-1beta 
               
               
                 Liver cirrhosis 
                 22.5 
                 21.0 
                 4.1 
               
               
                 Lupus kidney 
                 0.0 
                 0.0 
                 0.0 
               
               
                 NCI-H292 none 
                 6.2 
                 7.7 
                 22.7 
               
               
                 NCI-H292 IL-4 
                 4.2 
                 0.0 
                 23.0 
               
               
                 NCI-H292 IL-9 
                 3.7 
                 11.4 
                 9.0 
               
               
                 NCI-H292 IL-13 
                 17.0 
                 13.2 
                 17.1 
               
               
                 NCI-H292 IFN gamma 
                 0.0 
                 2.3 
                 13.0 
               
               
                 HPAEC none 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 8.4 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast none 
                 6.8 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast TNF alpha + 
                 0.0 
                 0.0 
                 6.6 
               
               
                 IL-1 beta 
               
               
                 Lung fibroblast IL-4 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-9 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-13 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IFN gamma 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 rest 
                 0.0 
                 2.8 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
                 2.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
                 0.0 
                 6.3 
               
               
                 Dermal fibroblast IFN gamma 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast IL-4 
                 0.0 
                 0.0 
                 0.0 
               
               
                 IBD Colitis 2 
                 3.5 
                 2.5 
                 19.9 
               
               
                 IBD Crohn&#39;s 
                 0.0 
                 13.3 
                 0.0 
               
               
                 Colon 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Lung 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Thymus 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Kidney 
                 87.1 
                 100.0 
                 100.0 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag548, Run 145909057    
               
               
                   Column B - Rel. Exp. (%) Ag548, Run 145928351    
               
               
                   Column C - Rel. Exp. (%) Ag548, Run 164886875    
               
            
           
         
       
     
      General_screening 13  panel_v1.7 Summary: Ag7880 Prominent expressin of this gene was seen in uterus and adipose (CTs=30).  
      Panel 1.2 Summary: Ag548 This gene was expressed at a very low level in this panel. The highest level of expression was seen in thymus (CT=34.33). Thus, expression of this gene is useful as a marker to differentiate thymus tissues from other samples on this panel.  
      Panel 1.3D Summary: Ag548 This gene was expressed at a very low level in this panel. The highest level of expression was seen in thymus (CT=34.33). Thus, expression of this gene is useful as a marker to differentiate thymus tissues from other samples on this panel.  
      Panel 2D Summary: Ag548 The highest level of expression in this panel was detected in a bladder cancer sample (CTs=30). Thus, expression of the gene or its protein product is useful as a marker to differentiate between normal and cancerous bladder tissue and therapeutic modulation of the gene product using antibodies , chimeric molecules or small molecule inhibitors is effective in the treatment of bladder cancer.  
      Panel 4D Summary: Ag548 This transcript was induced in small airway epithelium activated with TNFalpha+IL-1beta and was present in normal kidney. The transcript encodes a putative serpin like molecule (serine proteinase inhibitor). Serpins participate in multiple biological processes and mutations that alter serpin function can result in pulmonary dysfunction including asthma and emphysema. Therapies designed with the protein encoded for by this transcript are important for the treatment of lung disorders such as asthma and emphysema.  
      AA. CG54764-02: CALGIZZARIN  
      Expression of gene CG54764-02 was assessed using the primer-probe sets Ag1212 and Ag1528, described in Tables AAA and AAB. Results of the RTQ-PCR runs are shown in Tables AAC, AAD, AAE, AAF, and AAG.  
               TABLE AAA                          Probe Name Ag1212                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-gaccataacagctgcaaactct-3′   22   103   1387                   Probe   TET-5′-ttcatgaacactgtactggttgcctt-3′-   26   145   1388           TAMRA               Reverse   5′-agcccttctggttctttgtg-3′   20   171   1389                  
 
     
       
         
           
               
             
               
                 TABLE AAB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag1528 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-gaccataacagctgcaaactct-3′ 
                 22 
                 103 
                 1390 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-tgaacactgtactggttgccttcaca-3′- 
                 26 
                 149 
                 1391 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-ccagagcccttctggttct-3′ 
                 19 
                 176 
                 1392 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AAC 
               
             
            
               
                   
               
               
                   
               
               
                 CNS_neurodegeneration_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 AD 1 Hippo 
                 15.9 
               
               
                   
                 AD 2 Hippo 
                 18.7 
               
               
                   
                 AD 3 Hippo 
                 10.6 
               
               
                   
                 AD 4 Hippo 
                 24.5 
               
               
                   
                 AD 5 Hippo 
                 92.0 
               
               
                   
                 AD 6 Hippo 
                 13.4 
               
               
                   
                 Control 2 Hippo 
                 6.8 
               
               
                   
                 Control 4 Hippo 
                 8.7 
               
               
                   
                 Control (Path) 3 Hippo 
                 6.6 
               
               
                   
                 AD 1 Temporal Ctx 
                 30.8 
               
               
                   
                 AD 2 Temporal Ctx 
                 39.8 
               
               
                   
                 AD 3 Temporal Ctx 
                 40.9 
               
               
                   
                 AD 4 Temporal Ctx 
                 54.0 
               
               
                   
                 AD 5 Inf Temporal Ctx 
                 51.8 
               
               
                   
                 AD 5 Sup Temporal Ctx 
                 33.0 
               
               
                   
                 AD 6 Inf Temporal Ctx 
                 27.2 
               
               
                   
                 AD 6 Sup Temporal Ctx 
                 57.8 
               
               
                   
                 Control 1 Temporal Ctx 
                 21.6 
               
               
                   
                 Control 2 Temporal Ctx 
                 9.2 
               
               
                   
                 Control 3 Temporal Ctx 
                 44.4 
               
               
                   
                 Control 3 Temporal Ctx 
                 19.5 
               
               
                   
                 Control (Path) 1 Temporal Ctx 
                 54.3 
               
               
                   
                 Control (Path) 2 Temporal Ctx 
                 74.2 
               
               
                   
                 Control (Path) 3 Temporal Ctx 
                 9.1 
               
               
                   
                 Control (Path) 4 Temporal Ctx 
                 75.3 
               
               
                   
                 AD 1 Occipital Ctx 
                 31.0 
               
               
                   
                 AD 2 Occipital Ctx (Missing) 
                 2.8 
               
               
                   
                 AD 3 Occipital Ctx 
                 20.6 
               
               
                   
                 AD 4 Occipital Ctx 
                 55.1 
               
               
                   
                 AD 5 Occipital Ctx 
                 16.5 
               
               
                   
                 AD 6 Occipital Ctx 
                 27.5 
               
               
                   
                 Control 1 Occipital Ctx 
                 7.8 
               
               
                   
                 Control 2 Occipital Ctx 
                 17.1 
               
               
                   
                 Control 3 Occipital Ctx 
                 36.6 
               
               
                   
                 Control 4 Occipital Ctx 
                 8.4 
               
               
                   
                 Control (Path) 1 Occipital Ctx 
                 68.8 
               
               
                   
                 Control (Path) 2 Occipital Ctx 
                 43.5 
               
               
                   
                 Control (Path) 3 Occipital Ctx 
                 0.3 
               
               
                   
                 Control (Path) 4 Occipital Ctx 
                 100.0 
               
               
                   
                 Control 1 Parietal Ctx 
                 23.2 
               
               
                   
                 Control 2 Parietal Ctx 
                 38.2 
               
               
                   
                 Control 3 Parietal Ctx 
                 17.9 
               
               
                   
                 Control (Path) 1 Parietal Ctx 
                 42.9 
               
               
                   
                 Control (Path) 2 Parietal Ctx 
                 50.7 
               
               
                   
                 Control (Path) 3 Parietal Ctx 
                 5.7 
               
               
                   
                 Control (Path) 4 Parietal Ctx 
                 84.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1212, Run 206992259    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AAD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
                 C 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 17.1 
                 16.2 
                 11.8 
               
               
                   
                 Pancreas 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 3.9 
                 0.6 
                 2.3 
               
               
                   
                 Adrenal gland 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Thyroid 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Salivary gland 
                 0.0 
                 0.0 
                 1.4 
               
               
                   
                 Pituitary gland 
                 9.8 
                 11.1 
                 4.5 
               
               
                   
                 Brain (fetal) 
                 100.0 
                 32.5 
                 25.9 
               
               
                   
                 Brain (whole) 
                 80.1 
                 23.7 
                 36.6 
               
               
                   
                 Brain (amygdala) 
                 29.5 
                 27.0 
                 46.3 
               
               
                   
                 Brain (cerebellum) 
                 99.3 
                 17.3 
                 18.9 
               
               
                   
                 Brain (hippocampus) 
                 64.6 
                 32.1 
                 100.0 
               
               
                   
                 Brain (substantia nigra) 
                 10.2 
                 0.0 
                 4.0 
               
               
                   
                 Brain (thalamus) 
                 27.2 
                 17.0 
                 24.7 
               
               
                   
                 Cerebral Cortex 
                 30.8 
                 100.0 
                 66.0 
               
               
                   
                 Spinal cord 
                 2.6 
                 0.6 
                 1.2 
               
               
                   
                 glio/astro U87-MG 
                 38.4 
                 49.3 
                 17.6 
               
               
                   
                 glio/astro U-118-MG 
                 12.9 
                 8.8 
                 3.7 
               
               
                   
                 astrocytoma SW1783 
                 8.4 
                 7.3 
                 9.7 
               
               
                   
                 neuro*; met SK-N-AS 
                 1.4 
                 4.8 
                 5.6 
               
               
                   
                 astrocytoma SF-539 
                 10.2 
                 7.4 
                 8.0 
               
               
                   
                 astrocytoma SNB-75 
                 9.0 
                 14.6 
                 9.0 
               
               
                   
                 glioma SNB-19 
                 0.0 
                 0.8 
                 1.5 
               
               
                   
                 glioma U251 
                 13.7 
                 7.1 
                 4.4 
               
               
                   
                 glioma SF-295 
                 2.2 
                 0.0 
                 0.0 
               
               
                   
                 Heart (fetal) 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Heart 
                 1.6 
                 0.0 
                 0.0 
               
               
                   
                 Skeletal muscle (fetal) 
                 3.1 
                 1.4 
                 5.3 
               
               
                   
                 Skeletal muscle 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Bone marrow 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Thymus 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Spleen 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lymph node 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Colorectal 
                 0.0 
                 0.9 
                 2.7 
               
               
                   
                 Stomach 
                 0.0 
                 0.5 
                 1.3 
               
               
                   
                 Small intestine 
                 7.2 
                 0.0 
                 1.4 
               
               
                   
                 Colon ca. SW480 
                 0.0 
                 0.0 
                 1.2 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 0.0 
                 1.1 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
                 1.1 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 0.0 
                 2.8 
                 1.2 
               
               
                   
                 Colon ca. HCC-2998 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Bladder 
                 4.6 
                 4.4 
                 2.7 
               
               
                   
                 Trachea 
                 0.0 
                 3.5 
                 1.2 
               
               
                   
                 Kidney 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Kidney (fetal) 
                 0.0 
                 1.2 
                 0.0 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 6.7 
                 12.2 
                 6.7 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 7.3 
                 6.6 
                 2.1 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Liver 
                 3.1 
                 1.0 
                 0.0 
               
               
                   
                 Liver (fetal) 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung (fetal) 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 1.8 
                 9.4 
                 6.1 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 2.1 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.0 
                 3.5 
                 4.2 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 2.5 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 15.4 
                 13.7 
                 4.2 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 3.6 
                 12.5 
                 9.3 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 21.3 
                 20.9 
                 21.0 
               
               
                   
                 Mammary gland 
                 5.1 
                 7.4 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.0 
                 2.0 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
                 0.8 
                 1.2 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
                 32.1 
                 18.0 
               
               
                   
                 Ovary 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 40.1 
                 37.4 
                 18.6 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
                 0.0 
                 2.6 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 5.4 
                 0.0 
                 1.3 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 4.4 
                 1.2 
                 4.3 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
                 1.1 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.0 
                 15.5 
                 8.1 
               
               
                   
                 Uterus 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Placenta 
                 0.0 
                 2.2 
                 0.0 
               
               
                   
                 Prostate 
                 2.6 
                 0.0 
                 0.0 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 10.1 
                 1.1 
                 0.7 
               
               
                   
                 Testis 
                 3.0 
                 1.4 
                 4.1 
               
               
                   
                 Melanoma Hs688(A).T 
                 6.2 
                 37.6 
                 12.8 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 18.8 
                 54.7 
                 14.0 
               
               
                   
                 Melanoma UACC-62 
                 10.3 
                 1.0 
                 1.2 
               
               
                   
                 Melanoma M14 
                 85.3 
                 9.6 
                 26.4 
               
               
                   
                 Melanoma LOX IMVI 
                 23.2 
                 34.9 
                 57.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 9.6 
                 0.0 
                 14.6 
               
               
                   
                 Adipose 
                 2.0 
                 3.7 
                 2.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1212, Run 165519986    
               
               
                   
                   Column B - Rel. Exp. (%) Ag1528, Run 147327845    
               
               
                   
                   Column C - Rel. Exp. (%) Ag1528, Run 148390885    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AAE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Normal Colon 
                 7.4 
                 8.5 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 3.9 
                 2.3 
               
               
                   
                 CC Margin (ODO3866) 
                 0.0 
                 2.7 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 0.0 
                 4.7 
               
               
                   
                 CC Margin (ODO3868) 
                 0.0 
                 0.0 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 0.0 
                 0.0 
               
               
                   
                 CC Margin (ODO3920) 
                 0.0 
                 1.2 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 0.0 
                 0.0 
               
               
                   
                 CC Margin (ODO3921) 
                 1.9 
                 1.3 
               
               
                   
                 CC from Partial Hepatectomy 
                 0.0 
                 2.4 
               
               
                   
                 (ODO4309) Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 0.0 
                 1.3 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 0.0 
                 1.1 
               
               
                   
                 Lung Margin (OD04451-02) 
                 0.0 
                 0.0 
               
               
                   
                 Normal Prostate 6546-1 
                 0.0 
                 1.2 
               
               
                   
                 Prostate Cancer (OD04410) 
                 0.0 
                 0.0 
               
               
                   
                 Prostate Margin (OD04410) 
                 4.1 
                 0.0 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 4.0 
                 0.0 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 0.0 
                 1.1 
               
               
                   
                 Normal Lung 061010 
                 0.0 
                 3.9 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 0.0 
                 2.6 
               
               
                   
                 Muscle Margin (ODO4286) 
                 8.7 
                 0.0 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 0.0 
                 0.0 
               
               
                   
                 Lung Margin (OD03126) 
                 0.0 
                 0.5 
               
               
                   
                 Lung Cancer (OD04404) 
                 8.0 
                 21.9 
               
               
                   
                 Lung Margin (OD04404) 
                 0.0 
                 0.0 
               
               
                   
                 Lung Cancer (OD04565) 
                 3.2 
                 1.0 
               
               
                   
                 Lung Margin (OD04565) 
                 1.8 
                 1.2 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 9.0 
                 4.4 
               
               
                   
                 Lung Margin (OD04237-02) 
                 0.0 
                 0.0 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 0.0 
                 0.0 
               
               
                   
                 Liver Margin (ODO4310) 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 10.7 
                 9.5 
               
               
                   
                 Lung Margin (OD04321) 
                 0.0 
                 0.0 
               
               
                   
                 Normal Kidney 
                 10.4 
                 4.8 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04338) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04339) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04340) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.0 
                 1.1 
               
               
                   
                 Kidney Margin (OD04348) 
                 3.4 
                 0.6 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 0.0 
                 1.1 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 0.0 
                 6.7 
               
               
                   
                 Kidney Cancer 8120607 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin 8120608 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Cancer 8120613 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin 8120614 
                 1.2 
                 0.5 
               
               
                   
                 Kidney Cancer 9010320 
                 0.5 
                 1.1 
               
               
                   
                 Kidney Margin 9010321 
                 0.0 
                 0.0 
               
               
                   
                 Normal Uterus 
                 0.0 
                 0.6 
               
               
                   
                 Uterus Cancer 064011 
                 0.0 
                 0.0 
               
               
                   
                 Normal Thyroid 
                 1.8 
                 0.0 
               
               
                   
                 Thyroid Cancer 064010 
                 0.0 
                 0.0 
               
               
                   
                 Thyroid Cancer A302152 
                 5.0 
                 0.0 
               
               
                   
                 Thyroid Margin A302153 
                 0.0 
                 0.0 
               
               
                   
                 Normal Breast 
                 10.5 
                 5.3 
               
               
                   
                 Breast Cancer (OD04566) 
                 2.1 
                 4.3 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 1.3 
                 1.0 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 0.0 
                 0.0 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 0.0 
                 0.0 
               
               
                   
                 Breast Cancer 064006 
                 17.3 
                 8.7 
               
               
                   
                 Breast Cancer 1024 
                 10.1 
                 11.7 
               
               
                   
                 Breast Cancer 9100266 
                 0.0 
                 1.0 
               
               
                   
                 Breast Margin 9100265 
                 11.0 
                 1.9 
               
               
                   
                 Breast Cancer A209073 
                 9.1 
                 5.2 
               
               
                   
                 Breast Margin A209073 
                 17.0 
                 19.8 
               
               
                   
                 Normal Liver 
                 0.0 
                 0.0 
               
               
                   
                 Liver Cancer 064003 
                 1.8 
                 1.1 
               
               
                   
                 Liver Cancer 1025 
                 1.9 
                 1.1 
               
               
                   
                 Liver Cancer 1026 
                 0.0 
                 0.0 
               
               
                   
                 Liver Cancer 6004-T 
                 0.0 
                 0.0 
               
               
                   
                 Liver Tissue 6004-N 
                 3.6 
                 1.7 
               
               
                   
                 Liver Cancer 6005-T 
                 0.0 
                 0.0 
               
               
                   
                 Liver Tissue 6005-N 
                 0.0 
                 0.0 
               
               
                   
                 Normal Bladder 
                 4.2 
                 2.4 
               
               
                   
                 Bladder Cancer 1023 
                 0.0 
                 4.3 
               
               
                   
                 Bladder Cancer A302173 
                 100.0 
                 100.0 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 1.7 
                 12.4 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 1.9 
                 0.9 
               
               
                   
                 Normal Ovary 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian Cancer 064008 
                 0.0 
                 9.4 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 0.0 
                 0.0 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 0.0 
                 0.0 
               
               
                   
                 Normal Stomach 
                 0.0 
                 0.9 
               
               
                   
                 Gastric Cancer 9060358 
                 0.0 
                 0.8 
               
               
                   
                 Stomach Margin 9060359 
                 0.0 
                 0.0 
               
               
                   
                 Gastric Cancer 9060395 
                 1.3 
                 0.0 
               
               
                   
                 Stomach Margin 9060394 
                 0.0 
                 0.0 
               
               
                   
                 Gastric Cancer 9060397 
                 0.0 
                 0.0 
               
               
                   
                 Stomach Margin 9060396 
                 0.0 
                 0.0 
               
               
                   
                 Gastric Cancer 064005 
                 0.0 
                 2.6 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1528, Run 145158111    
               
               
                   
                   Column B - Rel. Exp. (%) Ag1528, Run 147327848    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AAF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Daoy- Medulloblastoma 
                 2.6 
               
               
                   
                 TE671- Medulloblastoma 
                 0.0 
               
               
                   
                 D283 Med- Medulloblastoma 
                 0.0 
               
               
                   
                 PFSK-1- Primitive Neuroectodermal 
                 10.6 
               
               
                   
                 XF-498- CNS 
                 81.8 
               
               
                   
                 SNB-78- Glioma 
                 8.8 
               
               
                   
                 SF-268- Glioblastoma 
                 11.9 
               
               
                   
                 T98G- Glioblastoma 
                 1.8 
               
               
                   
                 SK-N-SH- Neuroblastoma (metastasis) 
                 27.7 
               
               
                   
                 SF-295- Glioblastoma 
                 0.0 
               
               
                   
                 Cerebellum 
                 84.7 
               
               
                   
                 Cerebellum 
                 7.1 
               
               
                   
                 NCI-H292- Mucoepidermoid lung carcinoma 
                 1.0 
               
               
                   
                 DMS-114- Small cell lung cancer 
                 0.0 
               
               
                   
                 DMS-79- Small cell lung cancer 
                 38.4 
               
               
                   
                 NCI-H146- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H526- Small cell lung cancer 
                 24.5 
               
               
                   
                 NCI-N417- Small cell lung cancer 
                 9.4 
               
               
                   
                 NCI-H82- Small cell lung cancer 
                 20.0 
               
               
                   
                 NCI-H157- Squamous cell lung cancer 
                 39.2 
               
               
                   
                 (metastasis) 
               
               
                   
                 NCI-H1155- Large cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H1299- Large cell lung cancer 
                 60.7 
               
               
                   
                 NCI-H727- Lung carcinoid 
                 0.0 
               
               
                   
                 NCI-UMC-11- Lung carcinoid 
                 0.0 
               
               
                   
                 LX-1- Small cell lung cancer 
                 0.0 
               
               
                   
                 Colo-205- Colon cancer 
                 0.0 
               
               
                   
                 KM12- Colon cancer 
                 5.8 
               
               
                   
                 KM20L2- Colon cancer 
                 0.0 
               
               
                   
                 NCI-H716- Colon cancer 
                 0.0 
               
               
                   
                 SW-48- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW1116- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 LS 174T- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-948- Colon adenocarcinoma 
                 2.2 
               
               
                   
                 SW-480- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-5- Gastric carcinoma 
                 2.0 
               
               
                   
                 KATO III- Gastric carcinoma 
                 68.8 
               
               
                   
                 NCI-SNU-16- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-1- Gastric carcinoma 
                 13.8 
               
               
                   
                 RF-1- Gastric adenocarcinoma 
                 0.0 
               
               
                   
                 RF-48- Gastric adenocarcinoma 
                 0.0 
               
               
                   
                 MKN-45- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-N87- Gastric carcinoma 
                 0.0 
               
               
                   
                 OVCAR-5- Ovarian carcinoma 
                 0.0 
               
               
                   
                 RL95-2- Uterine carcinoma 
                 0.0 
               
               
                   
                 HelaS3- Cervical adenocarcinoma 
                 0.0 
               
               
                   
                 Ca Ski- Cervical epidermoid carcinoma 
                 40.6 
               
               
                   
                 (metastasis) 
               
               
                   
                 ES-2- Ovarian clear cell carcinoma 
                 29.7 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 4.5 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 9.4 
               
               
                   
                 MEG-01- Chronic myelogenous leukemia 
                 1.9 
               
               
                   
                 (megokaryoblast) 
               
               
                   
                 Raji- Burkitt&#39;s lymphoma 
                 9.8 
               
               
                   
                 Daudi- Burkitt&#39;s lymphoma 
                 100.0 
               
               
                   
                 U266- B-cell plasmacytoma 
                 0.0 
               
               
                   
                 CA46- Burkitt&#39;s lymphoma 
                 2.0 
               
               
                   
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 0.0 
               
               
                   
                 JM1- pre-B-cell lymphoma 
                 0.0 
               
               
                   
                 Jurkat- T cell leukemia 
                 0.0 
               
               
                   
                 TF-1- Erythroleukemia 
                 1.6 
               
               
                   
                 HUT 78- T-cell lymphoma 
                 0.0 
               
               
                   
                 U937- Histiocytic lymphoma 
                 0.0 
               
               
                   
                 KU-812- Myelogenous leukemia 
                 0.0 
               
               
                   
                 769-P- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 Caki-2- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 SW 839- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 Rhabdoid kidney tumor 
                 0.0 
               
               
                   
                 Hs766T- Pancreatic carcinoma (LN 
                 30.8 
               
               
                   
                 metastasis) 
               
               
                   
                 CAPAN-1- Pancreatic adenocarcinoma (liver 
                 6.8 
               
               
                   
                 metastasis) 
               
               
                   
                 SU86.86- Pancreatic carcinoma (liver 
                 50.7 
               
               
                   
                 metastasis) 
               
               
                   
                 BxPC-3- Pancreatic adenocarcinoma 
                 26.8 
               
               
                   
                 HPAC- Pancreatic adenocarcinoma 
                 4.4 
               
               
                   
                 MIA PaCa-2- Pancreatic carcinoma 
                 10.2 
               
               
                   
                 CFPAC-1- Pancreatic ductal adenocarcinoma 
                 3.8 
               
               
                   
                 PANC-1- Pancreatic epithelioid ductal 
                 12.7 
               
               
                   
                 carcinoma 
               
               
                   
                 T24- Bladder carcinma (transitional cell) 
                 33.4 
               
               
                   
                 5637- Bladder carcinoma 
                 24.1 
               
               
                   
                 HT-1197- Bladder carcinoma 
                 19.9 
               
               
                   
                 UM-UC-3- Bladder carcinma (transitional cell) 
                 5.1 
               
               
                   
                 A204- Rhabdomyosarcoma 
                 0.0 
               
               
                   
                 HT-1080- Fibrosarcoma 
                 95.3 
               
               
                   
                 MG-63- Osteosarcoma 
                 0.0 
               
               
                   
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 35.8 
               
               
                   
                 SJRH30- Rhabdomyosarcoma (met to bone 
                 13.6 
               
               
                   
                 marrow) 
               
               
                   
                 A431- Epidermoid carcinoma 
                 0.0 
               
               
                   
                 WM266-4- Melanoma 
                 12.3 
               
               
                   
                 DU 145- Prostate carcinoma (brain 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 MDA-MB-468- Breast adenocarcinoma 
                 5.1 
               
               
                   
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-9- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 CAL 27- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1212, Run 164038901    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AAG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
                 D 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Secondary Th1 act 
                 0.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 act 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 act 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
               
               
                 Secondary Th1 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.1 
               
               
                 Primary Th1 act 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th2 act 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 act 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th1 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th2 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CD45RA CD4 lymphocyte act 
                 0.7 
                 0.6 
                 0.8 
                 0.8 
               
               
                 CD45RO CD4 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CD8 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
                 0.9 
               
               
                 CD4 lymphocyte none 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 
                 0.0 
                 0.0 
                 0.1 
                 0.0 
               
               
                 LAK cells IL-2 + IL-12 
                 0.2 
                 0.0 
                 0.0 
                 0.1 
               
               
                 LAK cells IL-2 + IFN gamma 
                 0.0 
                 0.2 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-18 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 LAK cells PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 NK Cells IL-2 rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 3 day 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 5 day 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 7 day 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 PBMC rest 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 PBMC PWM 
                 0.0 
                 1.1 
                 0.2 
                 0.0 
               
               
                 PBMC PHA-L 
                 0.0 
                 0.0 
                 0.0 
                 0.1 
               
               
                 Ramos (B cell) none 
                 42.6 
                 21.0 
                 19.2 
                 21.6 
               
               
                 Ramos (B cell) ionomycin 
                 100.0 
                 100.0 
                 100.0 
                 100.0 
               
               
                 B lymphocytes PWM 
                 0.3 
                 0.5 
                 0.5 
                 0.2 
               
               
                 B lymphocytes CD40L and IL-4 
                 3.1 
                 4.0 
                 4.8 
                 7.2 
               
               
                 EOL-1 dbcAMP 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells none 
                 0.2 
                 0.1 
                 0.1 
                 0.2 
               
               
                 Dendritic cells LPS 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells anti-CD40 
                 0.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Monocytes rest 
                 0.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Monocytes LPS 
                 0.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Macrophages rest 
                 0.9 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Macrophages LPS 
                 0.1 
                 0.0 
                 0.0 
                 6.0 
               
               
                 HUVEC none 
                 3.8 
                 4.0 
                 3.8 
                 2.9 
               
               
                 HUVEC starved 
                 6.7 
                 5.1 
                 6.3 
                 5.0 
               
               
                 HUVEC IL-1beta 
                 2.3 
                 1.3 
                 2.8 
                 1.0 
               
               
                 HUVEC IFN gamma 
                 2.2 
                 2.0 
                 2.2 
                 1.3 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 0.3 
                 0.6 
                 0.9 
                 0.8 
               
               
                 HUVEC TNF alpha + IL4 
                 1.0 
                 1.3 
                 2.3 
                 1.4 
               
               
                 HUVEC IL-11 
                 2.1 
                 1.9 
                 3.0 
                 2.6 
               
               
                 Lung Microvascular EC none 
                 6.8 
                 5.1 
                 4.0 
                 3.9 
               
               
                 Lung Microvascular EC TNFalpha + 
                 1.9 
                 2.0 
                 3.6 
                 9.8 
               
               
                 IL-1beta 
               
               
                 Microvascular Dermal EC none 
                 8.4 
                 6.0 
                 4.6 
                 7.2 
               
               
                 Microsvasular Dermal EC TNFalpha + 
                 1.6 
                 3.5 
                 2.5 
                 3.6 
               
               
                 IL-1beta 
               
               
                 Bronchial epithelium TNFalpha + 
                 1.6 
                 0.0 
                 0.5 
                 0.0 
               
               
                 IL1beta 
               
               
                 Small airway epithelium none 
                 0.2 
                 0.5 
                 0.2 
                 0.3 
               
               
                 Small airway epithelium TNFalpha + 
                 2.8 
                 1.9 
                 1.8 
                 2.2 
               
               
                 IL-1beta 
               
               
                 Coronery artery SMC rest 
                 1.7 
                 1.6 
                 1.2 
                 0.5 
               
               
                 Coronery artery SMC TNFalpha + 
                 0.6 
                 0.9 
                 1.0 
                 0.2 
               
               
                 IL-1beta 
               
               
                 Astrocytes rest 
                 0.9 
                 2.0 
                 0.6 
                 0.8 
               
               
                 Astrocytes TNFalpha + IL-1beta 
                 0.7 
                 0.2 
                 0.5 
                 0.7 
               
               
                 KU-812 (Basophil) rest 
                 0.1 
                 0.0 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) none 
                 3.0 
                 4.5 
                 4.1 
                 3.5 
               
               
                 CCD1106 (Keratinocytes) TNFalpha + 
                 11.7 
                 0.7 
                 1.0 
                 0.4 
               
               
                 IL-1beta 
               
               
                 Liver cirrhosis 
                 1.5 
                 1.0 
                 0.7 
                 0.1 
               
               
                 Lupus kidney 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 NCI-H292 none 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IL-4 
                 0.5 
                 2.3 
                 0.3 
                 0.2 
               
               
                 NCI-H292 IL-9 
                 0.1 
                 0.1 
                 0.2 
                 0.3 
               
               
                 NCI-H292 IL-13 
                 0.2 
                 0.7 
                 0.2 
                 0.0 
               
               
                 NCI-H292 IFN gamma 
                 0.0 
                 0.1 
                 0.0 
                 0.1 
               
               
                 HPAEC none 
                 7.6 
                 8.7 
                 8.2 
                 7.5 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 2.0 
                 2.7 
                 3.0 
                 2.0 
               
               
                 Lung fibroblast none 
                 0.3 
                 0.2 
                 0.0 
                 0.2 
               
               
                 Lung fibroblast TNF alpha + 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
               
               
                 IL-1 beta 
               
               
                 Lung fibroblast IL-4 
                 0.1 
                 0.3 
                 0.5 
                 0.1 
               
               
                 Lung fibroblast IL-9 
                 0.3 
                 1.0 
                 0.6 
                 0.1 
               
               
                 Lung fibroblast IL-13 
                 1.4 
                 0.7 
                 0.1 
                 0.3 
               
               
                 Lung fibroblast IFN gamma 
                 0.0 
                 0.4 
                 0.2 
                 0.3 
               
               
                 Dermal fibroblast CCD1070 rest 
                 11.4 
                 8.8 
                 8.7 
                 4.9 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 6.7 
                 8.1 
                 9.2 
                 8.5 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 4.5 
                 2.1 
                 2.5 
                 4.7 
               
               
                 Dermal fibroblast IFN gamma 
                 0.8 
                 1.4 
                 1.0 
                 0.1 
               
               
                 Dermal fibroblast IL-4 
                 1.0 
                 1.1 
                 1.3 
                 1.4 
               
               
                 IBD Colitis 2 
                 0.0 
                 0.1 
                 0.1 
                 0.2 
               
               
                 IBD Crohn&#39;s 
                 0.2 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Colon 
                 0.0 
                 0.0 
                 0.1 
                 0.0 
               
               
                 Lung 
                 0.0 
                 0.1 
                 0.0 
                 0.0 
               
               
                 Thymus 
                 0.5 
                 0.3 
                 0.2 
                 0.4 
               
               
                 Kidney 
                 0.1 
                 0.1 
                 0.0 
                 0.0 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag1212, Run 140407622    
               
               
                   Column B - Rel. Exp. (%) Ag1528, Run 147327849    
               
               
                   Column C - Rel. Exp. (%) Ag1528, Run 148106604    
               
               
                   Column D - Rel. Exp. (%) Ag1528, Run 162699795    
               
            
           
         
       
     
      CNS_neurodegeneration_v1.0 Summary: Ag1212 Highest expression of this gene, a homolog of calgizzarin, was seen in the hippocampus of a patient with Alzheimer&#39;s disease. The gene was also expressed in numerous regions associated with Alzheimer&#39;s neurodegeneration including the hippocampus, cortex and amygdala, as seen below in Panels 1.2 and 1.3D. Calgizzarin (S100C, S100A11) accumulation in the nucleus is associated with cellular senescence, which may be critical in aging and age-related disorders such as Alzheimer&#39;s disease. Agents that bind S100C are cardioprotective and have been proven useful in extending life. Agents that block the action or nuclear localization of this gene or gene product are useful in the treatment of Alzheimer&#39;s disease and are effective in prolonging lifespan.  
      Panel 1.3D Summary: Ag1212/Ag1528 Highest expression of this gene was detected in the cortex, the fetal brain, and the hippocampus (CTs=31-33), with moderate expression across many regions of the brain. In addition, a substantial number of samples derived from melanoma and brain cancer cell lines showed expression of this gene. Thus, the expression of this gene is useful as a marker to distinguish melanoma cell lines, brain cancer cell lines and brain tissue from other samples in the panel. Therapeutic modulation of this gene or gene product, through the use of small molecule drugs, antibodies or protein therapeutics, is of benefit in the treatment of melanoma or brain cancer.  
      Panel 2D Summary: Ag1528 Highest expression of this gene was observed in bladder cancer (CTs=31), with significant over-expression in the bladder cancer samples when compared to expression in the normal adjacent tissue. There was also substantial expression in a cluster of samples derived from breast tissue. Expression of this gene is useful as a marker to distinguish bladder cancer and breast tissue from other samples in the panel. Therapeutic modulation of the expression of this gene or this gene product, through the use of small molecule drugs, antibodies or protein therapeutics is of use in the treatment of bladder cancer or breast disease.  
      Panel 3D Summary: Ag1212 Highest expression of this gene was seen in a cell line derived from a lymphoma cell line (Daudi) (CT=31.2). Low but significant expression was also seen in cell lines derived from brain cancer and lung cancer, as is seen in Panel 1.3D.  
      Panel 4D Summary: Ag1212/Ag1528 Highest expression of this gene was seen in ionomycin treated Ramos B cells (CTs=26-28). Lower levels of expression were also seen in dermal fibroblasts, HUVEC endothelial cells, and keratinocytes. The expression in keratinocytes of this gene product, a homolog of calgizzarin, is consistent with Robinson (J. Biol. Chem. 272: 12035.) Therapeutic modulation of the expression or function of this gene or gene product, through the use antibodies or protein therapeutics, is beneficial in the treatment of disease states associated with hyperactivation of keratinocytes. Higher expression of the gene product in a B cell line compared to the expression in a primary B cell line shows a role for the protein encoded by this gene in cell growth and/or differentiation. Therapeutic modulation of the expression or function of this gene product, through the use antibodies is beneficial in the treatment of B cell lymphomas.  
      AB. CG55033-01 and CG55033-04 and CG55033-05: LRR Domain Containing Protein  
      Expression of gene CG55033-01 and variants CG55033-04 and CG55033-05 was assessed using the primer-probe sets Ag1094, Ag6719 and Ag6725, described in Tables ABA, ABB and ABC. Results of the RTQ-PCR runs are shown in Tables ABE, ABF, ABG and ABH. Please note that Ag6725 is specific for the CG55033-04 and CG55033-05 variants only.  
               TABLE ABA                          Probe Name Ag1094                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-atggactggaaaacctggaa-3′   20   398   1393                   Probe   TET-5′-tcctgcaagcagataacaattttatcaca-3′-   29   419   1394           TAMRA               Reverse   5′-tgctaaaggcacttggttca-3′   20   453   1395                  
 
     
       
         
           
               
             
               
                 TABLE ABB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag6719 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-ggaaaatcattcaccactcaca-3′ 
                 22 
                 1575 
                 1396 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-acaaaaccacgaaccaatcaacagaa-3′- 
                 26 
                 1613 
                 1397 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-tctgtacaatgagctggcatct-3′ 
                 22 
                 1653 
                 1398 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ABC 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag6725 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-gaagctgtggattcatctctttt-3′ 
                 23 
                 3 
                 1399 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-catctctccttgcctgtatatctttacactcc- 
                 32 
                 29 
                 1400 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-ggatgagagcactggagtttg-3′ 
                 21 
                 61 
                 1401 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ABD 
               
             
            
               
                   
               
               
                   
               
               
                 Ardais Panel v.1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 136799_Lung cancer(362) 
                 0.1 
               
               
                   
                 136800_Lung NAT(363) 
                 4.8 
               
               
                   
                 136813_Lung cancer(372) 
                 37.4 
               
               
                   
                 136814_Lung NAT(373) 
                 2.8 
               
               
                   
                 136815_Lung cancer(374) 
                 19.9 
               
               
                   
                 136816_Lung NAT(375) 
                 4.3 
               
               
                   
                 136791_Lung cancer(35A) 
                 0.5 
               
               
                   
                 136795_Lung cancer(35E) 
                 100.0 
               
               
                   
                 136797_Lung cancer(360) 
                 0.2 
               
               
                   
                 136794_Lung NAT(35D) 
                 5.0 
               
               
                   
                 136818_Lung NAT(377) 
                 5.4 
               
               
                   
                 136787_lung cancer(356) 
                 0.2 
               
               
                   
                 136788_Lung NAT(357) 
                 0.7 
               
               
                   
                 136804_Lung cancer(369) 
                 1.1 
               
               
                   
                 136805_Lung NAT(36A) 
                 2.5 
               
               
                   
                 136806_Lung cancer(36B) 
                 18.2 
               
               
                   
                 136807_Lung NAT(36C) 
                 2.4 
               
               
                   
                 136789_lung cancer(358) 
                 0.7 
               
               
                   
                 136802_Lung cancer(365) 
                 0.1 
               
               
                   
                 136803_Lung cancer(368) 
                 1.1 
               
               
                   
                 136811_Lung cancer(370) 
                 4.5 
               
               
                   
                 136810_Lung NAT(36F) 
                 32.1 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1094, Run 263147830    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ABE 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.6 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 0.7 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma* M14 
                 0.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.6 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 7.4 
               
               
                   
                 Testis Pool 
                 0.5 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 28.1 
               
               
                   
                 Prostate Pool 
                 6.2 
               
               
                   
                 Placenta 
                 0.0 
               
               
                   
                 Uterus Pool 
                 0.3 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.4 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.4 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 10.3 
               
               
                   
                 Ovarian ca. IGROV-1 
                 10.2 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 1.0 
               
               
                   
                 Ovary 
                 0.0 
               
               
                   
                 Breast ca. MCF-7 
                 0.8 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca. BT 549 
                 0.9 
               
               
                   
                 Breast ca. T47D 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Breast Pool 
                 1.2 
               
               
                   
                 Trachea 
                 4.6 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Fetal Lung 
                 14.4 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 16.8 
               
               
                   
                 Lung ca. SHP-77 
                 100.0 
               
               
                   
                 Lung ca. A549 
                 2.7 
               
               
                   
                 Lung ca. NCI-H526 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 12.9 
               
               
                   
                 Lung ca. NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. HOP-62 
                 3.2 
               
               
                   
                 Lung ca. NCI-H522 
                 0.1 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 2.7 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
               
               
                   
                 Kidney Pool 
                 0.4 
               
               
                   
                 Fetal Kidney 
                 7.8 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.5 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Bladder 
                 0.1 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 9.5 
               
               
                   
                 Gastric ca. KATO III 
                 9.5 
               
               
                   
                 Colon ca. SW-948 
                 1.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.4 
               
               
                   
                 Colon ca. HT29 
                 15.5 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon cancer tissue 
                 0.0 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 1.0 
               
               
                   
                 Small Intestine Pool 
                 0.9 
               
               
                   
                 Stomach Pool 
                 1.1 
               
               
                   
                 Bone Marrow Pool 
                 0.6 
               
               
                   
                 Fetal Heart 
                 0.9 
               
               
                   
                 Heart Pool 
                 0.2 
               
               
                   
                 Lymph Node Pool 
                 0.5 
               
               
                   
                 Fetal Skeletal Muscle 
                 0.6 
               
               
                   
                 Skeletal Muscle Pool 
                 0.0 
               
               
                   
                 Spleen Pool 
                 0.0 
               
               
                   
                 Thymus Pool 
                 1.5 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.2 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 0.7 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 18.0 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 6.3 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 7.4 
               
               
                   
                 CNS cancer (glio) SF-295 
                 68.3 
               
               
                   
                 Brain (Amygdala) Pool 
                 0.6 
               
               
                   
                 Brain (cerebellum) 
                 0.2 
               
               
                   
                 Brain (fetal) 
                 0.7 
               
               
                   
                 Brain (Hippocampus) Pool 
                 0.3 
               
               
                   
                 Cerebral Cortex Pool 
                 0.1 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 0.1 
               
               
                   
                 Brain (Thalamus) Pool 
                 0.8 
               
               
                   
                 Brain (whole) 
                 0.1 
               
               
                   
                 Spinal Cord Pool 
                 0.3 
               
               
                   
                 Adrenal Gland 
                 0.0 
               
               
                   
                 Pituitary gland Pool 
                 0.0 
               
               
                   
                 Salivary Gland 
                 0.5 
               
               
                   
                 Thyroid (female) 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.0 
               
               
                   
                 Pancreas Pool 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag6719, Run 277223815    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ABF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Normal Colon 
                 12.4 
                 11.4 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 0.1 
                 0.0 
               
               
                   
                 CC Margin (ODO3866) 
                 1.0 
                 1.5 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 0.3 
                 0.1 
               
               
                   
                 CC Margin (ODO3868) 
                 0.4 
                 0.2 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 0.1 
                 0.1 
               
               
                   
                 CC Margin (ODO3920) 
                 0.8 
                 0.8 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 2.4 
                 2.2 
               
               
                   
                 CC Margin (ODO3921) 
                 2.0 
                 1.9 
               
               
                   
                 CC from Partial Hepatectomy 
                 0.0 
                 0.0 
               
               
                   
                 (ODO4309) Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 0.2 
                 0.3 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 0.1 
                 0.1 
               
               
                   
                 Lung Margin (OD04451-02) 
                 0.9 
                 0.6 
               
               
                   
                 Normal Prostate 6546-1 
                 2.7 
                 3.0 
               
               
                   
                 Prostate Cancer (OD04410) 
                 1.5 
                 1.4 
               
               
                   
                 Prostate Margin (OD04410) 
                 6.5 
                 8.0 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 5.9 
                 6.1 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 14.1 
                 12.6 
               
               
                   
                 Normal Lung 061010 
                 3.3 
                 3.5 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 0.2 
                 0.2 
               
               
                   
                 Muscle Margin (ODO4286) 
                 0.0 
                 0.0 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 7.9 
                 6.0 
               
               
                   
                 Lung Margin (OD03126) 
                 1.8 
                 2.5 
               
               
                   
                 Lung Cancer (OD04404) 
                 24.8 
                 21.6 
               
               
                   
                 Lung Margin (OD04404) 
                 1.8 
                 1.7 
               
               
                   
                 Lung Cancer (OD04565) 
                 0.7 
                 1.2 
               
               
                   
                 Lung Margin (OD04565) 
                 0.5 
                 0.7 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 13.5 
                 12.5 
               
               
                   
                 Lung Margin (OD04237-02) 
                 1.4 
                 1.0 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 0.0 
                 0.0 
               
               
                   
                 Liver Margin (ODO4310) 
                 0.2 
                 0.4 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.4 
                 0.2 
               
               
                   
                 Lung Margin (OD04321) 
                 2.5 
                 1.2 
               
               
                   
                 Normal Kidney 
                 0.2 
                 0.1 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04338) 
                 0.2 
                 0.2 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04339) 
                 0.1 
                 0.0 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 0.1 
                 0.2 
               
               
                   
                 Kidney Margin (OD04340) 
                 0.1 
                 0.2 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04348) 
                 0.0 
                 0.1 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 0.4 
                 0.4 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 0.0 
                 0.1 
               
               
                   
                 Kidney Cancer 8120607 
                 0.4 
                 0.3 
               
               
                   
                 Kidney Margin 8120608 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Cancer 8120613 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin 8120614 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Cancer 9010320 
                 0.1 
                 0.0 
               
               
                   
                 Kidney Margin 9010321 
                 0.0 
                 0.0 
               
               
                   
                 Normal Uterus 
                 0.1 
                 0.0 
               
               
                   
                 Uterus Cancer 064011 
                 0.5 
                 0.6 
               
               
                   
                 Normal Thyroid 
                 0.5 
                 0.4 
               
               
                   
                 Thyroid Cancer 064010 
                 0.0 
                 0.1 
               
               
                   
                 Thyroid Cancer A302152 
                 0.1 
                 0.1 
               
               
                   
                 Thyroid Margin A302153 
                 0.2 
                 0.1 
               
               
                   
                 Normal Breast 
                 5.5 
                 5.6 
               
               
                   
                 Breast Cancer (OD04566) 
                 0.5 
                 0.7 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 3.0 
                 3.9 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 1.4 
                 1.7 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 100.0 
                 100.0 
               
               
                   
                 Breast Cancer 064006 
                 1.7 
                 2.0 
               
               
                   
                 Breast Cancer 1024 
                 0.8 
                 0.8 
               
               
                   
                 Breast Cancer 9100266 
                 3.5 
                 4.1 
               
               
                   
                 Breast Margin 9100265 
                 3.5 
                 4.2 
               
               
                   
                 Breast Cancer A209073 
                 0.7 
                 0.7 
               
               
                   
                 Breast Margin A209073 
                 1.1 
                 1.3 
               
               
                   
                 Normal Liver 
                 2.0 
                 1.7 
               
               
                   
                 Liver Cancer 064003 
                 0.0 
                 0.1 
               
               
                   
                 Liver Cancer 1025 
                 0.3 
                 0.3 
               
               
                   
                 Liver Cancer 1026 
                 0.0 
                 0.0 
               
               
                   
                 Liver Cancer 6004-T 
                 0.3 
                 0.1 
               
               
                   
                 Liver Tissue 6004-N 
                 0.0 
                 0.1 
               
               
                   
                 Liver Cancer 6005-T 
                 0.0 
                 0.0 
               
               
                   
                 Liver Tissue 6005-N 
                 0.1 
                 0.1 
               
               
                   
                 Normal Bladder 
                 0.2 
                 0.1 
               
               
                   
                 Bladder Cancer 1023 
                 3.0 
                 3.1 
               
               
                   
                 Bladder Cancer A302173 
                 1.0 
                 0.8 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 0.0 
                 0.1 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 4.1 
                 3.4 
               
               
                   
                 Normal Ovary 
                 0.1 
                 0.0 
               
               
                   
                 Ovarian Cancer 064008 
                 1.6 
                 1.4 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 0.0 
                 0.0 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 0.1 
                 0.0 
               
               
                   
                 Normal Stomach 
                 1.0 
                 1.7 
               
               
                   
                 Gastric Cancer 9060358 
                 0.2 
                 0.2 
               
               
                   
                 Stomach Margin 9060359 
                 0.1 
                 0.2 
               
               
                   
                 Gastric Cancer 9060395 
                 0.4 
                 0.7 
               
               
                   
                 Stomach Margin 9060394 
                 0.4 
                 0.4 
               
               
                   
                 Gastric Cancer 9060397 
                 0.1 
                 0.3 
               
               
                   
                 Stomach Margin 9060396 
                 0.1 
                 0.2 
               
               
                   
                 Gastric Cancer 064005 
                 1.0 
                 1.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1094, Run 148015599    
               
               
                   
                   Column B - Rel. Exp. (%) Ag1094, Run 148572893    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ABG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D  
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Daoy- Medulloblastoma 
                 0.0 
               
               
                   
                 TE671- Medulloblastoma 
                 0.2 
               
               
                   
                 D283 Med- Medulloblastoma 
                 0.2 
               
               
                   
                 PFSK-1- Primitive Neuroectodermal 
                 1.6 
               
               
                   
                 XF-498- CNS 
                 30.4 
               
               
                   
                 SNB-78- Glioma 
                 0.7 
               
               
                   
                 SF-268- Glioblastoma 
                 0.0 
               
               
                   
                 T98G- Glioblastoma 
                 3.3 
               
               
                   
                 SK-N-SH- Neuroblastoma (metastasis) 
                 22.4 
               
               
                   
                 SF-295- Glioblastoma 
                 27.2 
               
               
                   
                 Cerebellum 
                 6.7 
               
               
                   
                 Cerebellum 
                 0.0 
               
               
                   
                 NCI-H292- Mucoepidermoid lung carcinoma 
                 21.9 
               
               
                   
                 DMS-114- Small cell lung cancer 
                 2.4 
               
               
                   
                 DMS-79- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H146- Small cell lung cancer 
                 100.0 
               
               
                   
                 NCI-H526- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-N417- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H82- Small cell lung cancer 
                 0.3 
               
               
                   
                 NCI-H157- Squamous cell lung cancer (metastasis) 
                 0.0 
               
               
                   
                 NCI-H1155- Large cell lung cancer 
                 65.1 
               
               
                   
                 NCI-H1299- Large cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H727- Lung carcinoid 
                 13.8 
               
               
                   
                 NCI-UMC-11- Lung carcinoid 
                 28.7 
               
               
                   
                 LX-1- Small cell lung cancer 
                 0.7 
               
               
                   
                 Colo-205- Colon cancer 
                 0.0 
               
               
                   
                 KM12- Colon cancer 
                 0.1 
               
               
                   
                 KM20L2- Colon cancer 
                 7.3 
               
               
                   
                 NCI-H716- Colon cancer 
                 80.1 
               
               
                   
                 SW-48- Colon adenocarcinoma 
                 0.3 
               
               
                   
                 SW1116- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 LS 174T- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-948- Colon adenocarcinoma 
                 0.6 
               
               
                   
                 SW-480- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-5- Gastric carcinoma 
                 0.0 
               
               
                   
                 KATO III- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-16- Gastric carcinoma 
                 1.7 
               
               
                   
                 NCI-SNU-1- Gastric carcinoma 
                 0.0 
               
               
                   
                 RF-1- Gastric adenocarcinoma 
                 0.0 
               
               
                   
                 RF-48- Gastric adenocarcinoma 
                 0.0 
               
               
                   
                 MKN-45- Gastric carcinoma 
                 0.1 
               
               
                   
                 NCI-N87- Gastric carcinoma 
                 2.4 
               
               
                   
                 OVCAR-5- Ovarian carcinoma 
                 0.0 
               
               
                   
                 RL95-2- Uterine carcinoma 
                 2.8 
               
               
                   
                 HelaS3- Cervical adenocarcinoma 
                 0.2 
               
               
                   
                 Ca Ski- Cervical epidermoid carcinoma 
                 0.1 
               
               
                   
                 (metastasis) 
               
               
                   
                 ES-2- Ovarian clear cell carcinoma 
                 0.0 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 0.1 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 0.0 
               
               
                   
                 MEG-01- Chronic myelogenous leukemia 
                 1.7 
               
               
                   
                 (megokaryoblast) 
               
               
                   
                 Raji- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 Daudi- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 U266- B-cell plasmacytoma 
                 0.2 
               
               
                   
                 CA46- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 0.1 
               
               
                   
                 JM1- pre-B-cell lymphoma 
                 0.0 
               
               
                   
                 Jurkat- T cell leukemia 
                 0.0 
               
               
                   
                 TF-1- Erythroleukemia 
                 2.1 
               
               
                   
                 HUT 78- T-cell lymphoma 
                 0.0 
               
               
                   
                 U937- Histiocytic lymphoma 
                 0.0 
               
               
                   
                 KU-812- Myelogenous leukemia 
                 8.2 
               
               
                   
                 769-P- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 Caki-2- Clear cell renal carcinoma 
                 0.3 
               
               
                   
                 SW 839- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 Rhabdoid kidney tumor 
                 0.0 
               
               
                   
                 Hs766T- Pancreatic carcinoma (LN metastasis) 
                 4.9 
               
               
                   
                 CAPAN-1- Pancreatic adenocarcinoma (liver 
                 0.3 
               
               
                   
                 metastasis) 
               
               
                   
                 SU86.86- Pancreatic carcinoma (liver metastasis) 
                 1.5 
               
               
                   
                 BxPC-3- Pancreatic adenocarcinoma 
                 23.7 
               
               
                   
                 HPAC- Pancreatic adenocarcinoma 
                 76.8 
               
               
                   
                 MIA PaCa-2- Pancreatic carcinoma 
                 0.5 
               
               
                   
                 CFPAC-1- Pancreatic ductal adenocarcinoma 
                 0.5 
               
               
                   
                 PANC-1- Pancreatic epithelioid ductal carcinoma 
                 6.9 
               
               
                   
                 T24- Bladder carcinma (transitional cell) 
                 4.1 
               
               
                   
                 5637- Bladder carcinoma 
                 1.0 
               
               
                   
                 HT-1197- Bladder carcinoma 
                 2.4 
               
               
                   
                 UM-UC-3- Bladder carcinma (transitional cell) 
                 0.0 
               
               
                   
                 A204- Rhabdomyosarcoma 
                 0.3 
               
               
                   
                 HT-1080- Fibrosarcoma 
                 0.2 
               
               
                   
                 MG-63- Osteosarcoma 
                 0.2 
               
               
                   
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 0.0 
               
               
                   
                 SJRH30- Rhabdomyosarcoma (met to bone marrow) 
                 0.2 
               
               
                   
                 A431- Epidermoid carcinoma 
                 0.0 
               
               
                   
                 WM266-4- Melanoma 
                 0.4 
               
               
                   
                 DU 145- Prostate carcinoma (brain metastasis) 
                 0.0 
               
               
                   
                 MDA-MB-468- Breast adenocarcinoma 
                 1.3 
               
               
                   
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.2 
               
               
                   
                 SCC-9- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.3 
               
               
                   
                 CAL 27- Squamous cell carcinoma of tongue 
                 1.6 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1094, Run 165022642    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ABH 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Secondary Th1 act 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 act 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 act 
                 0.0 
                 0.0 
               
               
                 Secondary Th1 rest 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 rest 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 rest 
                 0.0 
                 0.0 
               
               
                 Primary Th1 act 
                 0.0 
                 0.0 
               
               
                 Primary Th2 act 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 act 
                 0.0 
                 0.0 
               
               
                 Primary Th1 rest 
                 0.0 
                 0.0 
               
               
                 Primary Th2 rest 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 rest 
                 0.0 
                 0.0 
               
               
                 CD45RA CD4 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD45RO CD4 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte rest 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD4 lymphocyte none 
                 0.0 
                 0.0 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
                 0.0 
               
               
                 LAK cells rest 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-12 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IFN gamma 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-18 
                 0.0 
                 0.0 
               
               
                 LAK cells PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                 NK Cells IL-2 rest 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 3 day 
                 0.8 
                 0.0 
               
               
                 Two Way MLR 5 day 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 7 day 
                 0.0 
                 0.0 
               
               
                 PBMC rest 
                 0.0 
                 0.0 
               
               
                 PBMC PWM 
                 0.0 
                 0.0 
               
               
                 PBMC PHA-L 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) none 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) ionomycin 
                 0.6 
                 0.5 
               
               
                 B lymphocytes PWM 
                 0.0 
                 0.0 
               
               
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                 Dendritic cells none 
                 0.0 
                 0.0 
               
               
                 Dendritic cells LPS 
                 0.0 
                 0.0 
               
               
                 Dendritic cells anti-CD40 
                 0.0 
                 0.0 
               
               
                 Monocytes rest 
                 0.0 
                 0.0 
               
               
                 Monocytes LPS 
                 0.0 
                 0.0 
               
               
                 Macrophages rest 
                 0.0 
                 0.0 
               
               
                 Macrophages LPS 
                 0.0 
                 0.0 
               
               
                 HUVEC none 
                 0.0 
                 0.0 
               
               
                 HUVEC starved 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-1beta 
                 0.0 
                 0.0 
               
               
                 HUVEC IFN gamma 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IL4 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-11 
                 0.0 
                 0.0 
               
               
                 Lung Microvascular EC none 
                 0.0 
                 0.0 
               
               
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Microvascular Dermal EC none 
                 0.0 
                 0.0 
               
               
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Bronchial epithelium TNFalpha + IL1beta 
                 2.3 
                 4.0 
               
               
                 Small airway epithelium none 
                 3.7 
                 3.2 
               
               
                 Small airway epithelium TNFalpha + IL-1beta 
                 2.5 
                 1.2 
               
               
                 Coronery artery SMC rest 
                 0.0 
                 0.0 
               
               
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Astrocytes rest 
                 1.9 
                 2.5 
               
               
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) rest 
                 11.3 
                 1.7 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 61.1 
                 100.0 
               
               
                 CCD1106 (Keratinocytes) none 
                 100.0 
                 71.7 
               
               
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 7.6 
                 4.0 
               
               
                 Liver cirrhosis 
                 0.8 
                 0.2 
               
               
                 NCI-H292 none 
                 7.2 
                 6.4 
               
               
                 NCI-H292 IL-4 
                 4.6 
                 6.8 
               
               
                 NCI-H292 IL-9 
                 25.0 
                 8.4 
               
               
                 NCI-H292 IL-13 
                 9.7 
                 7.8 
               
               
                 NCI-H292 IFN gamma 
                 2.8 
                 1.9 
               
               
                 HPAEC none 
                 0.0 
                 0.0 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast none 
                 85.3 
                 53.6 
               
               
                 Lung fibroblast TNF alpha + IL-1 beta 
                 35.1 
                 31.0 
               
               
                 Lung fibroblast IL-4 
                 20.7 
                 7.8 
               
               
                 Lung fibroblast IL-9 
                 2.8 
                 7.3 
               
               
                 Lung fibroblast IL-13 
                 11.4 
                 3.0 
               
               
                 Lung fibroblast IFN gamma 
                 52.1 
                 38.2 
               
               
                 Dermal fibroblast CCD1070 rest 
                 0.3 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
                 1.0 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast IL-4 
                 0.0 
                 0.0 
               
               
                 Dermal Fibroblasts rest 
                 0.0 
                 0.0 
               
               
                 Neutrophils TNFa + LPS 
                 0.0 
                 0.0 
               
               
                 Neutrophils rest 
                 0.0 
                 0.0 
               
               
                 Colon 
                 1.5 
                 0.5 
               
               
                 Lung 
                 1.1 
                 0.7 
               
               
                 Thymus 
                 1.4 
                 0.0 
               
               
                 Kidney 
                 1.6 
                 0.0 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag6719, Run 276596890    
               
               
                   Column B - Rel. Exp. (%) Ag6725, Run 276846995    
               
            
           
         
       
     
      Ardais Panel v.1.0 Summary: Ag1094 Highest expression of this gene was seen in a lung cancer sample (CT=23.5). High to moderate expression of this gene was seen in a number of normal and cancerous samples from lung. Expression of this gene was higher in four cancer samples compared to normal lung samples. Expression of this gene is useful as a marker to detect the presence of lung cancer and therapeutic modulation of this gene or its protein product is useful in the treatment of lung cancer.  
      General_screening 13  panel_v1.6 Summary: Ag6719 Highest expression of this gene was seen in a lung cancer SHP-77 cell line (CT=26.6). High expression of this gene was mainly seen in cancer cell lines derived from brain, lung, colon, gastric, ovarian and prostate cancers. Expression was higher in these cell lines compared to the normal tissues. Expression of this gene is useful as a marker to detect the presence of these cancers and also, therapeutic modulation of this gene or its protein product is useful in the treatment of brain, lung, colon, gastric, ovarian and prostate cancers.  
      Low expression of this gene was also seen in fetal lung, fetal kidney, and fetal heart. Expression was higher in these fetal tissues compared to expression in the corresponding adult tissues. This gene plays a role in early development of these tissue. Therapeutic modulation of this gene or its protein product is useful in the treatment of diseases related to development of these tissues.  
      This gene encodes a novel insulin-like growth factor binding protein acid labile subunit. Low expression of this gene was also seen in fetal brain and thalamus. Therefore, therapeutic modulation of this gene or gene product is useful in the treatment of neurological disorders related to thalamus and brain development. Insulin-like growth factor (IGF) has neuroprotective effects, and is currently under investigation as a biopharmaceutical for the treatment of amyotropic lateral sclerosis (Mewar R. J. Neurosci. Res 50:721-728, PMID: 9418960; Corse A. M., Neurobiol. Dis. 6:335-346). In serum, IGF is bound to both IGF-binding protein (IGFBP) and the acid labile subunit (IGFBP-ALS). In the brain, glia produce IGFBP; however the IGFBP-ALS has not been detected in the CNS. This gene represents the CNS equivalent of IGFBP-ALS. Because of the neuroprotective effects of IGF, therapeutic modulation of this gene or its protein product is useful in treating diseases in which neuronal death/degeneration occur such as amyotropic lateral sclerosis, multiple sclerosis, Alzheimer&#39;s disease, Parkinson&#39;s disease, Huntington&#39;s disease, spinocerebellar ataxia, or CNS injury such as stroke, head or spinal cord trauma.  
      Panel 2D Summary: Ag1094 Expression of this gene was highest in a metastatic breast cancer sample (CT=26-27). In addition, several other breast cancer and lung cancer samples showed increased expression when compared to their normal adjacent margin samples. This result was consistent with the results in the Ardais panel, and Panel 1.6 that both showed higher expression of this gene in cell lines and lung cancer tissue. Expression of this gene is useful as a marker to distinguish breast cancer or lung cancer tissue from their normal counterparts and is of diagnostic value. Therapeutic modulation of the this gene or its gene product, through the use of small molecule drugs or antibodies, is of benefit for treatment of breast or lung cancer.  
      Panel 3D Summary: Ag1094 Expression of this gene was highest in a small cell lung cancer cell line (CT=28.5). In addition, there was significant expression of this gene in other lung cancer cell lines as well as in several brain cancer and pancreatic cancer cell lines. These results were consistent with what is observed in the other panels. Expression of this gene is useful as a marker to distinguish lung, breast or pancreas cancer cell line samples from other tissues. Therapeutic modulation of this gene or gene product, through the use of small molecule drugs or antibodies, is of benefit for treatment of lung, breast or pancreatic cancer.  
      Panel 4.1D Summary: Ag6719/Ag6725 Highest expression of this gene was seen in activated basophils and resting keratinocytes (CTs=30-31). Significant expression of this gene was also seen in resting basophils, activated keratinocytes, activated NCI-H292, resting and activated lung fibroblasts. This expression pattern is in agreement with that seen in panel 4D. Please see panel 4D for further discussion on the utility of this gene. The protein encoded by this transcript is a homolog of insulin-like growth factor binding protein acid labile subunit, a component of the systemic insulin-like growth factor-binding protein (IGFBP) complex. This gene plays an important role in the biology of circulating IGFs. IGFs are involved in a wide array of cellular processes such as proliferation, prevention of apoptosis, and differentiation. This gene is a suitable target for a small molecule, antibody, or protein therapeutic to modulate locally the mitogenic effect of IGF and as a treatment of emphysema, COPD, or skin related disease.  
      AC. CG55117-04: Prominin-like Protein 1 Precursor  
      Expression of gene CG55117-04 was assessed using the primer-probe set Ag819, described in Table ACA. Results of the RTQ-PCR runs are shown in Tables ACB, ACC, ACD, ACE and ACF.  
               TABLE ACA                          Probe Name Ag819                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-ggtccaacagggctatcaat-3′   20   1077   1402                   Probe   TET-5′-ccaaaccacgactgtcgtagcaggta-3′-   26   1128   1403           TAMRA               Reverse   5′-tggaattcaagacccttttga-3′   21   1154   1404                  
 
     
       
         
           
               
             
               
                 TABLE ACB 
               
             
            
               
                   
               
               
                   
               
               
                 HASS Panel v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 MCF-7 C1 
                 0.0 
               
               
                   
                 MCF-7 C2 
                 0.0 
               
               
                   
                 MCF-7 C3 
                 0.0 
               
               
                   
                 MCF-7 C4 
                 0.0 
               
               
                   
                 MCF-7 C5 
                 0.1 
               
               
                   
                 MCF-7 C6 
                 0.0 
               
               
                   
                 MCF-7 C7 
                 0.0 
               
               
                   
                 MCF-7 C9 
                 0.0 
               
               
                   
                 MCF-7 C10 
                 0.0 
               
               
                   
                 MCF-7 C11 
                 0.0 
               
               
                   
                 MCF-7 C12 
                 0.1 
               
               
                   
                 MCF-7 C13 
                 0.0 
               
               
                   
                 MCF-7 C15 
                 0.0 
               
               
                   
                 MCF-7 C16 
                 0.0 
               
               
                   
                 MCF-7 C17 
                 0.0 
               
               
                   
                 T24 D1 
                 0.0 
               
               
                   
                 T24 D2 
                 0.0 
               
               
                   
                 T24 D3 
                 0.1 
               
               
                   
                 T24 D4 
                 0.1 
               
               
                   
                 T24 D5 
                 0.1 
               
               
                   
                 T24 D6 
                 0.0 
               
               
                   
                 T24 D7 
                 0.0 
               
               
                   
                 T24 D9 
                 0.0 
               
               
                   
                 T24 D10 
                 0.0 
               
               
                   
                 T24 D11 
                 0.0 
               
               
                   
                 T24 D12 
                 0.0 
               
               
                   
                 T24 D13 
                 0.0 
               
               
                   
                 T24 D15 
                 0.0 
               
               
                   
                 T24 D16 
                 0.0 
               
               
                   
                 T24 D17 
                 0.0 
               
               
                   
                 CAPaN B1 
                 66.9 
               
               
                   
                 CAPaN B2 
                 50.7 
               
               
                   
                 CAPaN B3 
                 11.8 
               
               
                   
                 CAPaN B4 
                 42.3 
               
               
                   
                 CAPaN B5 
                 45.4 
               
               
                   
                 CAPaN B6 
                 73.7 
               
               
                   
                 CAPaN B7 
                 27.7 
               
               
                   
                 CAPaN B8 
                 17.6 
               
               
                   
                 CAPaN B9 
                 67.4 
               
               
                   
                 CAPaN B10 
                 100.0 
               
               
                   
                 CAPaN B11 
                 53.2 
               
               
                   
                 CAPaN B12 
                 55.9 
               
               
                   
                 CAPaN B13 
                 28.7 
               
               
                   
                 CAPaN B14 
                 15.3 
               
               
                   
                 CAPaN B15 
                 39.0 
               
               
                   
                 CAPaN B16 
                 44.8 
               
               
                   
                 CAPaN B17 
                 36.9 
               
               
                   
                 U87-MG F1 (B) 
                 0.1 
               
               
                   
                 U87-MG F2 
                 0.0 
               
               
                   
                 U87-MG F3 
                 0.0 
               
               
                   
                 U87-MG F4 
                 0.0 
               
               
                   
                 U87-MG F5 
                 0.1 
               
               
                   
                 U87-MG F6 
                 0.0 
               
               
                   
                 U87-MG F7 
                 0.3 
               
               
                   
                 U87-MG F8 
                 0.2 
               
               
                   
                 U87-MG F9 
                 0.3 
               
               
                   
                 U87-MG F10 
                 0.1 
               
               
                   
                 U87-MG F11 
                 0.0 
               
               
                   
                 U87-MG F12 
                 0.0 
               
               
                   
                 U87-MG F13 
                 0.7 
               
               
                   
                 U87-MG F14 
                 0.0 
               
               
                   
                 U87-MG F15 
                 0.5 
               
               
                   
                 U87-MG F16 
                 0.1 
               
               
                   
                 U87-MG F17 
                 0.1 
               
               
                   
                 LnCAP A1 
                 0.0 
               
               
                   
                 LnCAP A2 
                 0.0 
               
               
                   
                 LnCAP A3 
                 0.0 
               
               
                   
                 LnCAP A4 
                 0.0 
               
               
                   
                 LnCAP A5 
                 0.1 
               
               
                   
                 LnCAP A6 
                 0.1 
               
               
                   
                 LnCAP A7 
                 0.0 
               
               
                   
                 LnCAP A8 
                 0.1 
               
               
                   
                 LnCAP A9 
                 0.0 
               
               
                   
                 LnCAP A10 
                 0.0 
               
               
                   
                 LnCAP A11 
                 0.0 
               
               
                   
                 LnCAP A12 
                 0.0 
               
               
                   
                 LnCAP A13 
                 0.0 
               
               
                   
                 LnCAP A14 
                 0.0 
               
               
                   
                 LnCAP A15 
                 0.0 
               
               
                   
                 LnCAP A16 
                 0.0 
               
               
                   
                 LnCAP A17 
                 0.0 
               
               
                   
                 Primary Astrocytes 
                 37.6 
               
               
                   
                 Primary Renal Proximal Tubule Epithelial cell A2 
                 38.2 
               
               
                   
                 Primary melanocytes A5 
                 0.1 
               
               
                   
                 126443 - 341 medullo 
                 0.4 
               
               
                   
                 126444 - 487 medullo 
                 4.8 
               
               
                   
                 126445 - 425 medullo 
                 0.0 
               
               
                   
                 126446 - 690 medullo 
                 1.8 
               
               
                   
                 126447 - 54 adult glioma 
                 0.0 
               
               
                   
                 126448 - 245 adult glioma 
                 1.5 
               
               
                   
                 126449 - 317 adult glioma 
                 10.7 
               
               
                   
                 126450 - 212 glioma 
                 5.9 
               
               
                   
                 126451 - 456 glioma 
                 60.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag819, Run 268362651    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ACC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.2 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Endothelial cells 
                 0.0 
                 0.0 
               
               
                   
                 Heart (Fetal) 
                 0.4 
                 0.8 
               
               
                   
                 Pancreas 
                 43.8 
                 48.3 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 8.1 
                 17.9 
               
               
                   
                 Adrenal Gland 
                 0.2 
                 0.2 
               
               
                   
                 Thyroid 
                 11.8 
                 12.9 
               
               
                   
                 Salivary gland 
                 63.3 
                 63.7 
               
               
                   
                 Pituitary gland 
                 0.9 
                 0.5 
               
               
                   
                 Brain (fetal) 
                 37.1 
                 41.5 
               
               
                   
                 Brain (whole) 
                 4.6 
                 6.3 
               
               
                   
                 Brain (amygdala) 
                 1.5 
                 2.3 
               
               
                   
                 Brain (cerebellum) 
                 0.9 
                 1.5 
               
               
                   
                 Brain (hippocampus) 
                 3.4 
                 4.0 
               
               
                   
                 Brain (thalamus) 
                 1.9 
                 2.6 
               
               
                   
                 Cerebral Cortex 
                 1.2 
                 2.7 
               
               
                   
                 Spinal cord 
                 1.2 
                 1.9 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.3 
                 0.1 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 0.0 
                 0.0 
               
               
                   
                 glioma SNB-19 
                 0.0 
                 0.1 
               
               
                   
                 glioma U251 
                 0.0 
                 0.1 
               
               
                   
                 glioma SF-295 
                 0.0 
                 0.0 
               
               
                   
                 Heart 
                 8.1 
                 9.5 
               
               
                   
                 Skeletal Muscle 
                 2.6 
                 3.7 
               
               
                   
                 Bone marrow 
                 0.6 
                 1.2 
               
               
                   
                 Thymus 
                 0.0 
                 0.1 
               
               
                   
                 Spleen 
                 0.5 
                 0.0 
               
               
                   
                 Lymph node 
                 1.4 
                 0.2 
               
               
                   
                 Colorectal Tissue 
                 0.3 
                 1.8 
               
               
                   
                 Stomach 
                 10.7 
                 23.3 
               
               
                   
                 Small intestine 
                 10.4 
                 18.9 
               
               
                   
                 Colon ca. SW480 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca.* SW620 (SW480 met) 
                 9.0 
                 11.7 
               
               
                   
                 Colon ca. HT29 
                 32.5 
                 40.9 
               
               
                   
                 Colon ca. HCT-116 
                 5.9 
                 7.9 
               
               
                   
                 Colon ca. CaCo-2 
                 100.0 
                 100.0 
               
               
                   
                 Colon ca. Tissue (ODO3866) 
                 4.7 
                 5.4 
               
               
                   
                 Colon ca. HCC-2998 
                 2.5 
                 3.0 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.0 
                 0.2 
               
               
                   
                 Bladder 
                 39.2 
                 49.7 
               
               
                   
                 Trachea 
                 29.7 
                 34.4 
               
               
                   
                 Kidney 
                 27.4 
                 25.7 
               
               
                   
                 Kidney (fetal) 
                 17.7 
                 19.1 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
                 0.1 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 1.0 
                 1.6 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
                 0.0 
               
               
                   
                 Liver 
                 8.0 
                 3.3 
               
               
                   
                 Liver (fetal) 
                 2.8 
                 2.7 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 12.8 
                 20.2 
               
               
                   
                 Lung 
                 5.7 
                 4.2 
               
               
                   
                 Lung (fetal) 
                 9.5 
                 7.4 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 39.0 
                 33.4 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 7.4 
                 10.5 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.5 
                 0.6 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.0 
                 0.1 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.1 
                 0.2 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
                 0.1 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.6 
                 0.8 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 14.6 
                 22.1 
               
               
                   
                 Mammary gland 
                 33.0 
                 46.3 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.8 
                 1.3 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.4 
                 0.6 
               
               
                   
                 Ovary 
                 4.6 
                 0.2 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 3.3 
                 4.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 27.9 
                 54.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 37.4 
                 51.1 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
                 0.1 
               
               
                   
                 Ovarian ca. IGROV-1 
                 3.2 
                 5.5 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 0.0 
                 0.0 
               
               
                   
                 Uterus 
                 1.4 
                 1.2 
               
               
                   
                 Placenta 
                 23.2 
                 22.5 
               
               
                   
                 Prostate 
                 2.6 
                 2.7 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
                 0.0 
               
               
                   
                 Testis 
                 19.8 
                 21.9 
               
               
                   
                 Melanoma Hs688(A).T 
                 1.7 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.7 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 1.8 
                 1.7 
               
               
                   
                 Melanoma M14 
                 0.1 
                 0.2 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.5 
                 1.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag819, Run 118349021    
               
               
                   
                   Column B - Rel. Exp. (%) Ag819, Run 120989791    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ACD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Normal Colon 
                 17.0 
                 20.7 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 0.9 
                 5.3 
               
               
                   
                 CC Margin (ODO3866) 
                 9.5 
                 6.0 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 5.8 
                 3.9 
               
               
                   
                 CC Margin (ODO3868) 
                 0.0 
                 0.2 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 0.7 
                 0.9 
               
               
                   
                 CC Margin (ODO3920) 
                 2.8 
                 2.1 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 26.2 
                 37.4 
               
               
                   
                 CC Margin (ODO3921) 
                 4.4 
                 7.0 
               
               
                   
                 CC from Partial Hepatectomy 
                 13.1 
                 20.4 
               
               
                   
                 (ODO4309) Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 0.1 
                 0.2 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 8.5 
                 6.2 
               
               
                   
                 Lung Margin (OD04451-02) 
                 2.1 
                 1.7 
               
               
                   
                 Normal Prostate 6546-1 
                 1.2 
                 0.3 
               
               
                   
                 Prostate Cancer (OD04410) 
                 0.5 
                 0.7 
               
               
                   
                 Prostate Margin (OD04410) 
                 0.8 
                 0.6 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 0.4 
                 0.4 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 2.0 
                 2.0 
               
               
                   
                 Normal Lung 061010 
                 4.6 
                 4.7 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 0.0 
                 0.0 
               
               
                   
                 Muscle Margin (ODO4286) 
                 0.2 
                 0.3 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 8.7 
                 6.5 
               
               
                   
                 Lung Margin (OD03126) 
                 1.4 
                 1.6 
               
               
                   
                 Lung Cancer (OD04404) 
                 0.1 
                 0.2 
               
               
                   
                 Lung Margin (OD04404) 
                 3.1 
                 1.2 
               
               
                   
                 Lung Cancer (OD04565) 
                 0.2 
                 0.1 
               
               
                   
                 Lung Margin (OD04565) 
                 1.0 
                 0.9 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 100.0 
                 74.7 
               
               
                   
                 Lung Margin (OD04237-02) 
                 1.7 
                 1.5 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 0.1 
                 0.3 
               
               
                   
                 Liver Margin (ODO4310) 
                 0.6 
                 0.2 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 14.8 
                 12.2 
               
               
                   
                 Lung Margin (OD04321) 
                 1.7 
                 1.5 
               
               
                   
                 Normal Kidney 
                 23.2 
                 17.4 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 4.2 
                 5.1 
               
               
                   
                 Kidney Margin (OD04338) 
                 8.0 
                 11.3 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 65.5 
                 69.3 
               
               
                   
                 Kidney Margin (OD04339) 
                 6.7 
                 6.0 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 0.1 
                 0.1 
               
               
                   
                 Kidney Margin (OD04340) 
                 13.8 
                 12.0 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04348) 
                 9.2 
                 6.3 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 0.7 
                 0.4 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 1.1 
                 1.2 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 32.5 
                 24.5 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 22.1 
                 16.0 
               
               
                   
                 Kidney Cancer 8120607 
                 4.4 
                 4.2 
               
               
                   
                 Kidney Margin 8120608 
                 3.9 
                 2.0 
               
               
                   
                 Kidney Cancer 8120613 
                 0.1 
                 0.0 
               
               
                   
                 Kidney Margin 8120614 
                 1.2 
                 0.8 
               
               
                   
                 Kidney Cancer 9010320 
                 7.7 
                 8.0 
               
               
                   
                 Kidney Margin 9010321 
                 7.8 
                 6.0 
               
               
                   
                 Normal Uterus 
                 0.0 
                 0.0 
               
               
                   
                 Uterus Cancer 064011 
                 24.1 
                 18.8 
               
               
                   
                 Normal Thyroid 
                 4.7 
                 2.4 
               
               
                   
                 Thyroid Cancer 064010 
                 4.0 
                 2.2 
               
               
                   
                 Thyroid Cancer A302152 
                 0.1 
                 0.0 
               
               
                   
                 Thyroid Margin A302153 
                 2.9 
                 2.7 
               
               
                   
                 Normal Breast 
                 16.6 
                 7.4 
               
               
                   
                 Breast Cancer (OD04566) 
                 0.6 
                 0.4 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 0.8 
                 0.5 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 0.0 
                 0.0 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 0.1 
                 0.0 
               
               
                   
                 Breast Cancer 064006 
                 15.7 
                 11.7 
               
               
                   
                 Breast Cancer 1024 
                 12.1 
                 11.6 
               
               
                   
                 Breast Cancer 9100266 
                 1.2 
                 0.6 
               
               
                   
                 Breast Margin 9100265 
                 3.0 
                 2.0 
               
               
                   
                 Breast Cancer A209073 
                 6.5 
                 4.6 
               
               
                   
                 Breast Margin A209073 
                 25.0 
                 9.0 
               
               
                   
                 Normal Liver 
                 0.6 
                 0.5 
               
               
                   
                 Liver Cancer 064003 
                 0.0 
                 0.0 
               
               
                   
                 Liver Cancer 1025 
                 0.2 
                 0.3 
               
               
                   
                 Liver Cancer 1026 
                 0.2 
                 0.1 
               
               
                   
                 Liver Cancer 6004-T 
                 0.2 
                 0.1 
               
               
                   
                 Liver Tissue 6004-N 
                 1.6 
                 1.7 
               
               
                   
                 Liver Cancer 6005-T 
                 0.1 
                 0.2 
               
               
                   
                 Liver Tissue 6005-N 
                 0.0 
                 0.2 
               
               
                   
                 Normal Bladder 
                 14.8 
                 18.7 
               
               
                   
                 Bladder Cancer 1023 
                 6.9 
                 6.4 
               
               
                   
                 Bladder Cancer A302173 
                 0.2 
                 0.1 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 0.1 
                 0.1 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 0.2 
                 0.4 
               
               
                   
                 Normal Ovary 
                 0.1 
                 0.0 
               
               
                   
                 Ovarian Cancer 064008 
                 68.8 
                 100.0 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 0.5 
                 1.0 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 0.0 
                 0.1 
               
               
                   
                 Normal Stomach 
                 5.0 
                 4.5 
               
               
                   
                 Gastric Cancer 9060358 
                 2.5 
                 2.6 
               
               
                   
                 Stomach Margin 9060359 
                 5.6 
                 7.0 
               
               
                   
                 Gastric Cancer 9060395 
                 1.7 
                 1.3 
               
               
                   
                 Stomach Margin 9060394 
                 3.4 
                 6.4 
               
               
                   
                 Gastric Cancer 9060397 
                 26.1 
                 39.8 
               
               
                   
                 Stomach Margin 9060396 
                 2.7 
                 2.7 
               
               
                   
                 Gastric Cancer 064005 
                 15.5 
                 22.1 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag819, Run 144794769    
               
               
                   
                   Column B - Rel. Exp. (%) Ag819, Run 146791894    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ACE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D 
               
            
           
           
               
               
            
               
                 Tissue Name 
                 A 
               
               
                   
               
            
           
           
               
               
            
               
                 Daoy- Medulloblastoma 
                 0.9 
               
               
                 TE671- Medulloblastoma 
                 1.1 
               
               
                 D283 Med- Medulloblastoma 
                 100.0 
               
               
                 PFSK-1- Primitive Neuroectodermal 
                 0.0 
               
               
                 XF-498- CNS 
                 0.1 
               
               
                 SNB-78- Glioma 
                 0.0 
               
               
                 SF-268- Glioblastoma 
                 0.0 
               
               
                 T98G- Glioblastoma 
                 0.0 
               
               
                 SK-N-SH- Neuroblastoma (metastasis) 
                 0.0 
               
               
                 SF-295- Glioblastoma 
                 0.0 
               
               
                 Cerebellum 
                 0.8 
               
               
                 Cerebellum 
                 0.2 
               
               
                 NCI-H292- Mucoepidermoid lung carcinoma 
                 0.0 
               
               
                 DMS-114- Small cell lung cancer 
                 0.1 
               
               
                 DMS-79- Small cell lung cancer 
                 9.9 
               
               
                 NCI-H146- Small cell lung cancer 
                 1.2 
               
               
                 NCI-H526- Small cell lung cancer 
                 0.0 
               
               
                 NCI-N417- Small cell lung cancer 
                 0.0 
               
               
                 NCI-H82- Small cell lung cancer 
                 28.5 
               
               
                 NCI-H157- Squamous cell lung cancer (metastasis) 
                 0.0 
               
               
                 NCI-H1155- Large cell lung cancer 
                 3.4 
               
               
                 NCI-H1299- Large cell lung cancer 
                 0.0 
               
               
                 NCI-H727- Lung carcinoid 
                 0.4 
               
               
                 NCI-UMC-11- Lung carcinoid 
                 10.4 
               
               
                 LX-1- Small cell lung cancer 
                 27.9 
               
               
                 Colo-205- Colon cancer 
                 3.0 
               
               
                 KM12- Colon cancer 
                 3.3 
               
               
                 KM20L2- Colon cancer 
                 1.2 
               
               
                 NCI-H716- Colon cancer 
                 0.0 
               
               
                 SW-48- Colon adenocarcinoma 
                 7.3 
               
               
                 SW1116- Colon adenocarcinoma 
                 3.7 
               
               
                 LS 174T- Colon adenocarcinoma 
                 0.2 
               
               
                 SW-948- Colon adenocarcinoma 
                 0.0 
               
               
                 SW-480- Colon adenocarcinoma 
                 3.1 
               
               
                 NCI-SNU-5- Gastric carcinoma 
                 0.0 
               
               
                 KATO III- Gastric carcinoma 
                 0.0 
               
               
                 NCI-SNU-16- Gastric carcinoma 
                 0.0 
               
               
                 NCI-SNU-1- Gastric carcinoma 
                 26.6 
               
               
                 RF-1- Gastric adenocarcinoma 
                 0.0 
               
               
                 RF-48- Gastric adenocarcinoma 
                 0.1 
               
               
                 MKN-45- Gastric carcinoma 
                 0.0 
               
               
                 NCI-N87- Gastric carcinoma 
                 0.0 
               
               
                 OVCAR-5- Ovarian carcinoma 
                 0.0 
               
               
                 RL95-2- Uterine carcinoma 
                 0.0 
               
               
                 HelaS3- Cervical adenocarcinoma 
                 0.0 
               
               
                 Ca Ski- Cervical epidermoid carcinoma (metastasis) 
                 0.0 
               
               
                 ES-2- Ovarian clear cell carcinoma 
                 0.0 
               
               
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 0.0 
               
               
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 0.0 
               
               
                 MEG-01- Chronic myelogenous leukemia (megokaryoblast) 
                 0.0 
               
               
                 Raji- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                 Daudi- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                 U266- B-cell plasmacytoma 
                 0.0 
               
               
                 CA46- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 0.0 
               
               
                 JM1- pre-B-cell lymphoma 
                 0.0 
               
               
                 Jurkat- T cell leukemia 
                 0.0 
               
               
                 TF-1- Erythroleukemia 
                 0.0 
               
               
                 HUT 78- T-cell lymphoma 
                 0.0 
               
               
                 U937- Histiocytic lymphoma 
                 0.0 
               
               
                 KU-812- Myelogenous leukemia 
                 0.0 
               
               
                 769-P- Clear cell renal carcinoma 
                 0.0 
               
               
                 Caki-2- Clear cell renal carcinoma 
                 0.0 
               
               
                 SW 839- Clear cell renal carcinoma 
                 0.0 
               
               
                 Rhabdoid kidney tumor 
                 0.0 
               
               
                 Hs766T- Pancreatic carcinoma (LN metastasis) 
                 0.0 
               
               
                 CAPAN-1- Pancreatic adenocarcinoma (liver metastasis) 
                 9.0 
               
               
                 SU86.86- Pancreatic carcinoma (liver metastasis) 
                 17.6 
               
               
                 BxPC-3- Pancreatic adenocarcinoma 
                 0.0 
               
               
                 HPAC- Pancreatic adenocarcinoma 
                 1.7 
               
               
                 MIA PaCa-2- Pancreatic carcinoma 
                 0.0 
               
               
                 CFPAC-1- Pancreatic ductal adenocarcinoma 
                 58.2 
               
               
                 PANC-1- Pancreatic epithelioid ductal carcinoma 
                 0.0 
               
               
                 T24- Bladder carcinoma (transitional cell) 
                 0.0 
               
               
                 5637- Bladder carcinoma 
                 0.0 
               
               
                 HT-1197- Bladder carcinoma 
                 0.0 
               
               
                 UM-UC-3- Bladder carcinoma (transitional cell) 
                 0.0 
               
               
                 A204- Rhabdomyosarcoma 
                 0.0 
               
               
                 HT-1080- Fibrosarcoma 
                 0.0 
               
               
                 MG-63- Osteosarcoma 
                 0.0 
               
               
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 0.0 
               
               
                 SJRH30- Rhabdomyosarcoma (met to bone marrow) 
                 2.5 
               
               
                 A431- Epidermoid carcinoma 
                 0.0 
               
               
                 WM266-4- Melanoma 
                 0.2 
               
               
                 DU 145- Prostate carcinoma (brain metastasis) 
                 0.0 
               
               
                 MDA-MB-468- Breast adenocarcinoma 
                 11.2 
               
               
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                 SCC-9- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                 CAL 27- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag819, Run 172133330    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ACF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 5 Islet 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 97457_Patient-02go_adipose 
                 0.0 
               
               
                   
                 97476_Patient-07sk_skeletal muscle 
                 0.5 
               
               
                   
                 97477_Patient-07ut_uterus 
                 0.0 
               
               
                   
                 97478_Patient-07pl_placenta 
                 12.4 
               
               
                   
                 99167_Bayer Patient 1 
                 7.9 
               
               
                   
                 97482_Patient-08ut_uterus 
                 0.4 
               
               
                   
                 97483_Patient-08pl_placenta 
                 20.9 
               
               
                   
                 97486_Patient-09sk_skeletal muscle 
                 0.0 
               
               
                   
                 97487_Patient-09ut_uterus 
                 0.0 
               
               
                   
                 97488_Patient-09pl_placenta 
                 11.0 
               
               
                   
                 97492_Patient-10ut_uterus 
                 8.1 
               
               
                   
                 97493_Patient-10pl_placenta 
                 47.0 
               
               
                   
                 97495_Patient-11go_adipose 
                 0.0 
               
               
                   
                 97496_Patient-11sk_skeletal muscle 
                 1.2 
               
               
                   
                 97497_Patient-11ut_uterus 
                 1.5 
               
               
                   
                 97498_Patient-11pl_placenta 
                 5.4 
               
               
                   
                 97500_Patient-12go_adipose 
                 0.0 
               
               
                   
                 97501_Patient-12sk_skeletal muscle 
                 1.1 
               
               
                   
                 97502_Patient-12ut_uterus 
                 0.0 
               
               
                   
                 97503_Patient-12pl_placenta 
                 11.7 
               
               
                   
                 94721_Donor 2 U - A_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94722_Donor 2 U - B_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94723_Donor 2 U - C_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94709_Donor 2 AM - A_adipose 
                 0.0 
               
               
                   
                 94710_Donor 2 AM - B_adipose 
                 0.0 
               
               
                   
                 94711_Donor 2 AM - C_adipose 
                 0.0 
               
               
                   
                 94712_Donor 2 AD - A_adipose 
                 0.0 
               
               
                   
                 94713_Donor 2 AD - B_adipose 
                 0.3 
               
               
                   
                 94714_Donor 2 AD - C_adipose 
                 0.0 
               
               
                   
                 94742_Donor 3 U - A_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94743_Donor 3 U - B_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94730_Donor 3 AM - A_adipose 
                 0.0 
               
               
                   
                 94731_Donor 3 AM - B_adipose 
                 0.0 
               
               
                   
                 94732_Donor 3 AM - C_adipose 
                 0.0 
               
               
                   
                 94733_Donor 3 AD - A_adipose 
                 0.0 
               
               
                   
                 94734_Donor 3 AD - B_adipose 
                 0.0 
               
               
                   
                 94735_Donor 3 AD - C_adipose 
                 0.0 
               
               
                   
                 77138_Liver_HepG2untreated 
                 100.0 
               
               
                   
                 73556_Heart_Cardiac stromal cells (primary) 
                 0.0 
               
               
                   
                 81735_Small Intestine 
                 38.2 
               
               
                   
                 72409_Kidney_Proximal Convoluted Tubule 
                 4.9 
               
               
                   
                 82685_Small intestine_Duodenum 
                 1.0 
               
               
                   
                 90650_Adrenal_Adrenocortical adenoma 
                 0.0 
               
               
                   
                 72410_Kidney_HRCE 
                 39.5 
               
               
                   
                 72411_Kidney_HRE 
                 97.9 
               
               
                   
                 73139_Uterus_Uterine smooth muscle cells 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag819, Run 229431867    
               
            
           
         
       
     
      HASS Panel v1.0 Summary: Ag819 Highest expression of this gene was detected in the pancreatic cancer CaPaN cell lines subjected to acidosis (CT=27.9). Moderate levels of expression of this gene were seen in control and in CaPaN cells subjected to environmental stress. The expression of this gene was not significantly changed by oxygen deprivation, acidic or a serum starved environment in these cells. However, moderate to low expression was also shown in astrocytes, Renal Proximal Tubule Epithelial cell A2, ⅘ glioma and 2/4 medulloblastoma tissue samples in this panel. Therapeutic modulation of this gene, expressed protein and/or use of antibodies or small molecule drugs is useful in the treatment of pancreatic and brain cancers.  
      Panel 1.2 Summary: Ag819 The expression of this gene was highest in a colon cancer cell line (CaCo-2)(CTs=25). In addition, significant expression of this gene wais also seen in colon, ovarian, lung, pancreatic and a renal cancer cell lines. The expression of this gene is useful as a marker to detect the presence of these cancers and therapeutic modulation of this gene, expressed protein and/or use of antibodies or small molecule drug is useful in the treatment of these cancers.  
      Among tissues with metabolic function, this gene had moderate levels of expression in pancreas, adrenal gland, thyroid, pituitary gland, skeletal muscle, and adult and fetal liver. Modulation of this gene and/or expressed protein is useful in the treatment of diseases of the metabolic-endocrine axis, including obesity and Types 1 and 2 diabetes. In addition, this gene was differentially expressed in adult (CT value=28) vs fetal heart (CT value=32-33), and targeting this gene or gene product with small molecule, antibody, or protein therapeutics is of use in the treatment of heart related disorders.  
      This gene also showed moderate to low expression in all CNS regions examined, with highest expression in the fetal brain (greater than 10-fold) demonstrating a role in neurodevelopment. This gene codes for a Prominin like protein. Prominin plays a role in the formation of lipid membrane protrusions, their lipid content and membrane to membrane interactions; all critical for synapse formation. The expression of this gene in the developing brain shows a role in synaptogenesis for this molecule. Compensatory synaptogenesis has been shown to occur in the adult brain, especially in response to brain injury or neuronal loss. Therapeutic modulation of this gene and/or expressed protein is useful in the treatment of neurological disorders including stroke, head trauma, spinal cord trauma, Alzheimer&#39;s, Parkinson&#39;s or Huntington&#39;s diseases, multiple sclerosis, or ALS.  
      Panel 2D Summary: Ag819 Highest expression of this gene was detected in samples derived from an ovarian cancer and a lung cancer (CTs=26). Significant expression of this gene was seen in a number of cancer samples including a kidney cancer, two colon cancers and two gastric cancers. The expression of this gene is useful as a marker to detect the presence of ovarian or lung cancers. Therapeutic modulation of this gene, expressed protein and/or use of antibodies or small molecule drugs is of benefit in the treatment of ovarian, lung, kidney, colon or gastric cancers.  
      Panel 3D Summary: Ag819 The expression of this gene was highest in a sample derived from a brain cancer (meduloblastoma) cell line (D283 cells)(CT=28.3). Significant expression of this gene was also seen in several cell lines derived from lung, gastric and pancreatic cancers. Expression of this gene is useful as a marker to detect these cancers and therapeutic modulation of this gene, expressed protein, and/or use of antibodies or small molecule drugs targeting this gene or gene product is useful in the treatment of lung, brain, pancreatic or gastric cancers.  
      Panel 5 Islet Summary: Ag819 Highest expression of this gene was detected in liver cancer HepG2 cell line (CT=31). Low levels of expression of this gene are also seen in islets cells (Bayer patient 1), small intestine, kidney and placenta. Therefore, modulation of this gene and/or expressed protein is useful in treatment of metabolic diseases including obesity and type II diabetes.  
      AD. CG55193-04: PV1 Protein  
      Expression of gene CG55193-04 was assessed using the primer-probe sets Ag1537 and Ag4932, described in Tables ADA and ADB. Results of the RTQ-PCR runs are shown in Tables ADD, ADE, ADF, ADG, ADH and ADI.  
               TABLE ADA                          Probe Name Ag1537                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-aaggagctggaagagaagaaga-3′   22   1087   1405                   Probe   TET-5′-atcagaaactcagccctggacacctg-3′-   26   1141   1406           TAMRA               Reverse   5′-gctgcgacttggtcttgat-3′   19   1168   1407                  
 
     
       
         
           
               
             
               
                 TABLE ADB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag4932 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-aatgcagagatcaattcaagga-3′ 
                 22 
                 425 
                 1408 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-aacaagagctgcgatgccttgctctt-3′- 
                 26 
                 451 
                 1409 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-tcttcaccttctgattcagcat-3′ 
                 22 
                 478 
                 1410 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ADC 
               
             
            
               
                   
               
               
                   
               
               
                 Ardais Kidney 1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Kidney cancer(10A8) 
                 2.3 
               
               
                   
                 Kidney NAT(10A9) 
                 6.9 
               
               
                   
                 Kidney cancer(10AA) 
                 100.0 
               
               
                   
                 Kidney NAT(10AB) 
                 7.4 
               
               
                   
                 Kidney cancer(10AC) 
                 25.7 
               
               
                   
                 Kidney NAT(10AD) 
                 5.3 
               
               
                   
                 Kidney cancer(10B6) 
                 8.7 
               
               
                   
                 Kidney NAT(10B7) 
                 4.5 
               
               
                   
                 Kidney cancer(10B8) 
                 2.2 
               
               
                   
                 Kidney NAT(10B9) 
                 10.6 
               
               
                   
                 Kidney cancer(10BC) 
                 2.0 
               
               
                   
                 Kidney NAT(10BD) 
                 20.2 
               
               
                   
                 Kidney cancer(10BE) 
                 23.5 
               
               
                   
                 Kidney NAT(10BF) 
                 9.7 
               
               
                   
                 Kidney cancer(10C2) 
                 1.1 
               
               
                   
                 Kidney NAT(10C3) 
                 9.1 
               
               
                   
                 Kidney cancer(10C4) 
                 14.4 
               
               
                   
                 Kidney NAT(10C5) 
                 9.4 
               
               
                   
                 Kidney cancer(10B4) 
                 2.2 
               
               
                   
                 Kidney cancer(10C8) 
                 14.5 
               
               
                   
                 Kidney cancer(10D0) 
                 60.3 
               
               
                   
                 Kidney cancer(10C0) 
                 1.2 
               
               
                   
                 Kidney cancer(10C6) 
                 3.3 
               
               
                   
                 Kidney cancer(10C9) 
                 1.5 
               
               
                   
                 Kidney cancer(10D1) 
                 85.3 
               
               
                   
                 Kidney cancer(10CA) 
                 0.8 
               
               
                   
                 Kidney cancer(10D2) 
                 55.1 
               
               
                   
                 Kidney cancer(10CB) 
                 6.4 
               
               
                   
                 Kidney cancer(10D4) 
                 22.1 
               
               
                   
                 Kidney cancer(10CD) 
                 73.2 
               
               
                   
                 Kidney cancer(10D5) 
                 7.4 
               
               
                   
                 Kidney cancer(10CE) 
                 63.3 
               
               
                   
                 Kidney cancer(10D6) 
                 38.2 
               
               
                   
                 Kidney cancer(10CF) 
                 22.8 
               
               
                   
                 Kidney cancer(10D8) 
                 25.7 
               
               
                   
                 Kidney cancer(10CC) 
                 28.1 
               
               
                   
                 Kidney cancer(10D3) 
                 12.0 
               
               
                   
                 Kidney NAT(10D9) 
                 7.4 
               
               
                   
                 Kidney NAT(10DB) 
                 7.2 
               
               
                   
                 Kidney NAT(10DC) 
                 10.8 
               
               
                   
                 Kidney NAT(10DD) 
                 12.9 
               
               
                   
                 Kidney NAT(10DE) 
                 20.7 
               
               
                   
                 Kidney NAT(10B1) 
                 7.5 
               
               
                   
                 Kidney NAT(10DA) 
                 7.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1537, Run 385860665    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ADD 
               
             
            
               
                   
               
               
                   
               
               
                 Ardais Panel v.1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 136799_Lung cancer(362) 
                 23.8 
               
               
                   
                 136800_Lung NAT(363) 
                 15.6 
               
               
                   
                 136813_Lung cancer(372) 
                 45.4 
               
               
                   
                 136814_Lung NAT(373) 
                 14.4 
               
               
                   
                 136815_Lung cancer(374) 
                 39.2 
               
               
                   
                 136816_Lung NAT(375) 
                 100.0 
               
               
                   
                 136791_Lung cancer(35A) 
                 22.5 
               
               
                   
                 136795_Lung cancer(35E) 
                 35.4 
               
               
                   
                 136797_Lung cancer(360) 
                 22.4 
               
               
                   
                 136794_lung NAT(35D) 
                 14.3 
               
               
                   
                 136818_Lung NAT(377) 
                 33.0 
               
               
                   
                 136787_lung cancer(356) 
                 8.1 
               
               
                   
                 136788_lung NAT(357) 
                 52.5 
               
               
                   
                 136806_Lung cancer(36B) 
                 35.6 
               
               
                   
                 136807_Lung NAT(36C) 
                 18.8 
               
               
                   
                 136789_lung cancer(358) 
                 65.1 
               
               
                   
                 136802_Lung cancer(365) 
                 49.3 
               
               
                   
                 136803_Lung cancer(368) 
                 24.5 
               
               
                   
                 136804_Lung cancer(369) 
                 38.2 
               
               
                   
                 136811_Lung cancer(370) 
                 14.9 
               
               
                   
                 136810_Lung NAT(36F) 
                 31.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1537, Run 267680189    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ADE 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.5  
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 0.0 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma* M14 
                 0.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.0 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.0 
               
               
                   
                 Testis Pool 
                 10.7 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate Pool 
                 14.7 
               
               
                   
                 Placenta 
                 42.6 
               
               
                   
                 Uterus Pool 
                 53.6 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.2 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.1 
               
               
                   
                 Ovary 
                 11.1 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca. BT 549 
                 0.0 
               
               
                   
                 Breast ca. T47D 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Breast Pool 
                 62.4 
               
               
                   
                 Trachea 
                 47.3 
               
               
                   
                 Lung 
                 4.3 
               
               
                   
                 Fetal Lung 
                 17.2 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.0 
               
               
                   
                 Lung ca. A549 
                 0.0 
               
               
                   
                 Lung ca. NCI-H526 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 0.0 
               
               
                   
                 Lung ca. NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. HOP-62 
                 0.0 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
               
               
                   
                 Liver 
                 1.2 
               
               
                   
                 Fetal Liver 
                 44.1 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
               
               
                   
                 Kidney Pool 
                 55.1 
               
               
                   
                 Fetal Kidney 
                 73.2 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.1 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Bladder 
                 86.5 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 4.5 
               
               
                   
                 Gastric ca. KATO III 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon cancer tissue 
                 51.1 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 89.5 
               
               
                   
                 Small Intestine Pool 
                 11.7 
               
               
                   
                 Stomach Pool 
                 37.9 
               
               
                   
                 Bone Marrow Pool 
                 46.0 
               
               
                   
                 Fetal Heart 
                 15.1 
               
               
                   
                 Heart Pool 
                 22.2 
               
               
                   
                 Lymph Node Pool 
                 66.9 
               
               
                   
                 Fetal Skeletal Muscle 
                 23.2 
               
               
                   
                 Skeletal Muscle Pool 
                 32.5 
               
               
                   
                 Spleen Pool 
                 100.0 
               
               
                   
                 Thymus Pool 
                 30.6 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 0.1 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.1 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 0.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.7 
               
               
                   
                 Brain (Amygdala) Pool 
                 1.0 
               
               
                   
                 Brain (cerebellum) 
                 2.0 
               
               
                   
                 Brain (fetal) 
                 2.6 
               
               
                   
                 Brain (Hippocampus) Pool 
                 2.1 
               
               
                   
                 Cerebral Cortex Pool 
                 1.3 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 1.5 
               
               
                   
                 Brain (Thalamus) Pool 
                 2.5 
               
               
                   
                 Brain (whole) 
                 3.8 
               
               
                   
                 Spinal Cord Pool 
                 1.9 
               
               
                   
                 Adrenal Gland 
                 55.1 
               
               
                   
                 Pituitary gland Pool 
                 10.3 
               
               
                   
                 Salivary Gland 
                 20.7 
               
               
                   
                 Thyroid (female) 
                 70.7 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.0 
               
               
                   
                 Pancreas Pool 
                 53.6 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag4932, Run 228843451    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ADF 
               
             
            
               
                   
               
               
                   
               
               
                 Oncology_cell_line_screening_panel_v3.2 
               
            
           
           
               
               
            
               
                 Tissue Name 
                 A 
               
               
                   
               
            
           
           
               
               
            
               
                 94905_Daoy_Medulloblastoma/Cerebellum_sscDNA 
                 0.0 
               
               
                 94906_TE671_Medulloblastom/Cerebellum_sscDNA 
                 0.0 
               
               
                 94907_D283 
                 0.0 
               
               
                 Med_Medulloblastoma/Cerebellum_sscDNA 
               
               
                 94908_PFSK-1_Primitive 
                 0.5 
               
               
                 Neuroectodermal/Cerebellum_sscDNA 
               
               
                 94909_XF-498_CNS_sscDNA 
                 0.0 
               
               
                 94910_SNB-78_CNS/glioma_sscDNA 
                 0.0 
               
               
                 94911_SF-268_CNS/glioblastoma_sscDNA 
                 0.0 
               
               
                 94912_T98G_Glioblastoma_sscDNA 
                 0.0 
               
               
                 96776_SK-N-SH_Neuroblastoma (metastasis)_sscDNA 
                 0.0 
               
               
                 94913_SF-295_CNS/glioblastoma_sscDNA 
                 0.0 
               
               
                 132565_NT2 pool_sscDNA 
                 0.1 
               
               
                 94914_Cerebellum_sscDNA 
                 0.2 
               
               
                 96777_Cerebellum_sscDNA 
                 0.3 
               
               
                 94916_NCI-H292_Mucoepidermoid lung carcinoma_sscDNA 
                 0.0 
               
               
                 94917_DMS-114_Small cell lung cancer_sscDNA 
                 0.0 
               
               
                 94918_DMS-79_Small cell lung 
                 0.0 
               
               
                 cancer/neuroendocrine_sscDNA 
               
               
                 94919_NCI-H146_Small cell 
                 0.0 
               
               
                 lung cancer/neuroendocrine_sscDNA 
               
               
                 94920_NCI-H526_Small cell 
                 0.0 
               
               
                 lung cancer/neuroendocrine_sscDNA 
               
               
                 94921_NCI-N417_Small cell 
                 0.0 
               
               
                 lung cancer/neuroendocrine_sscDNA 
               
               
                 94923_NCI-H82_Small cell lung 
                 0.0 
               
               
                 cancer/neuroendocrine_sscDNA 
               
               
                 94924_NCI-H157_Squamous cell lung cancer 
                 0.0 
               
               
                 (metastasis)_sscDNA 
               
               
                 94925_NCI-H1155_Large cell lung 
                 0.0 
               
               
                 cancer/neuroendocrine_sscDNA 
               
               
                 94926_NCI-H1299_Large cell lung 
                 0.0 
               
               
                 cancer/neuroendocrine_sscDNA 
               
               
                 94927_NCI-H727_Lung carcinoid_sscDNA 
                 0.0 
               
               
                 94928_NCI-UMC-11_Lung carcinoid_sscDNA 
                 0.0 
               
               
                 94929_LX-1_Small cell lung cancer_sscDNA 
                 0.0 
               
               
                 94930_Colo-205_Colon cancer_sscDNA 
                 0.0 
               
               
                 94931_KM12_Colon cancer_sscDNA 
                 0.0 
               
               
                 94932_KM20L2_Colon cancer_sscDNA 
                 0.0 
               
               
                 94933_NCI-H716_Colon cancer_sscDNA 
                 0.0 
               
               
                 94935_SW-48_Colon adenocarcinoma_sscDNA 
                 0.0 
               
               
                 94936_SW1116_Colon 
                 0.0 
               
               
                 adenocarcinoma_sscDNA 
               
               
                 94937_LS 174T_Colon adenocarcinoma_sscDNA 
                 0.0 
               
               
                 94938_SW-948_Colon adenocarcinoma_sscDNA 
                 0.0 
               
               
                 94939_SW-480_Colon adenocarcinoma_sscDNA 
                 0.0 
               
               
                 94940_NCI-SNU-5_Gastric carcinoma_sscDNA 
                 0.0 
               
               
                 112197_KATO III_Stomach_sscDNA 
                 0.0 
               
               
                 94943_NCI-SNU-16_Gastric carcinoma_sscDNA 
                 0.0 
               
               
                 94944_NCI-SNU-1_Gastric carcinoma_sscDNA 
                 0.0 
               
               
                 94946_RF-1_Gastric adenocarcinoma_sscDNA 
                 0.0 
               
               
                 94947_RF-48_Gastric adenocarcinoma_sscDNA 
                 0.1 
               
               
                 96778_MKN-45_Gastric carcinoma_sscDNA 
                 0.0 
               
               
                 94949_NCI-N87_Gastric carcinoma_sscDNA 
                 0.0 
               
               
                 94951_OVCAR-5_Ovarian carcinoma_sscDNA 
                 0.0 
               
               
                 94952_RL95-2_Uterine carcinoma_sscDNA 
                 0.0 
               
               
                 94953_HelaS3_Cervical adenocarcinoma_sscDNA 
                 0.0 
               
               
                 94954_Ca Ski_Cervical epidermoid carcinoma 
                 0.2 
               
               
                 (metastasis)_sscDNA 
               
               
                 94955_ES-2_Ovarian clear cell carcinoma_sscDNA 
                 0.0 
               
               
                 94957_Ramos/6 h stim_Stimulated with PMA/ionomycin 
                 0.0 
               
               
                 6 h_sscDNA 
               
               
                 94958_Ramos/14 h stim_Stimulated with PMA/ionomycin 
                 0.0 
               
               
                 14 h_sscDNA 
               
               
                 94962_MEG-01_Chronic myelogenous leukemia 
                 0.7 
               
               
                 (megokaryoblast)_sscDNA 
               
               
                 94963_Raji_Burkitt&#39;s lymphoma_sscDNA 
                 0.0 
               
               
                 94964_Daudi_Burkitt&#39;s lymphoma_sscDNA 
                 0.8 
               
               
                 94965_U266_B-cell plasmacytoma/myeloma_sscDNA 
                 1.3 
               
               
                 94968_CA46_Burkitt&#39;s lymphoma_sscDNA 
                 0.2 
               
               
                 94970_RL_non-Hodgkin&#39;s B-cell lymphoma_sscDNA 
                 0.0 
               
               
                 94972_JM1_pre-B-cell lymphoma/leukemia_sscDNA 
                 0.0 
               
               
                 94973_Jurkat_T cell leukemia_sscDNA 
                 0.0 
               
               
                 94974_TF-1_Erythroleukemia_sscDNA 
                 100.0 
               
               
                 94975_HUT 78_T-cell lymphoma_sscDNA 
                 0.0 
               
               
                 94977_U937_Histiocytic lymphoma_sscDNA 
                 0.0 
               
               
                 94980_KU-812_Myelogenous leukemia_sscDNA 
                 28.9 
               
               
                 94981_769-P_Clear cell renal carcinoma_sscDNA 
                 0.1 
               
               
                 94983_Caki-2_Clear cell renal carcinoma_sscDNA 
                 0.0 
               
               
                 94984_SW 839_Clear cell renal carcinoma_sscDNA 
                 0.0 
               
               
                 94986_G401_Wilms&#39; tumor_sscDNA 
                 0.0 
               
               
                 126768_293 cells_sscDNA 
                 0.0 
               
               
                 94987_Hs766T_Pancreatic carcinoma (LN 
                 0.6 
               
               
                 metastasis)_sscDNA 
               
               
                 94988_CAPAN-1_Pancreatic adenocarcinoma (liver 
                 0.0 
               
               
                 metastasis)_sscDNA 
               
               
                 94989_SU86.86_Pancreatic carcinoma (liver 
                 0.0 
               
               
                 metastasis)_sscDNA 
               
               
                 94990_BxPC-3_Pancreatic adenocarcinoma_sscDNA 
                 0.0 
               
               
                 94991_HPAC_Pancreatic adenocarcinoma_sscDNA 
                 0.0 
               
               
                 94992_MIA PaCa-2_Pancreatic carcinoma_sscDNA 
                 0.0 
               
               
                 94993_CFPAC-1_Pancreatic ductal 
                 0.1 
               
               
                 adenocarcinoma_sscDNA 
               
               
                 94994_PANC-1_Pancreatic epithelioid ductal 
                 0.0 
               
               
                 carcinoma_sscDNA 
               
               
                 94996_T24_Bladder carcinoma (transitional 
                 0.1 
               
               
                 cell)_sscDNA 
               
               
                 94997_5637_Bladder carcinoma_sscDNA 
                 0.0 
               
               
                 94998_HT-1197_Bladder carcinoma_sscDNA 
                 0.0 
               
               
                 94999_UM-UC-3_Bladder carcinoma (transitional 
                 0.0 
               
               
                 cell)_sscDNA 
               
               
                 95000_A204_Rhabdomyosarcoma_sscDNA 
                 0.0 
               
               
                 95001_HT-1080_Fibrosarcoma_sscDNA 
                 0.0 
               
               
                 95002_MG-63_Osteosarcoma (bone)_sscDNA 
                 0.0 
               
               
                 95003_SK-LMS-1_Leiomyosarcoma (vulva)_sscDNA 
                 0.2 
               
               
                 95004_SJRH30_Rhabdomyosarcoma (met to bone 
                 0.0 
               
               
                 marrow)_sscDNA 
               
               
                 95005_A431_Epidermoid carcinoma_sscDNA 
                 0.0 
               
               
                 95007_WM266-4_Melanoma_sscDNA 
                 0.0 
               
               
                 112195_DU 145_Prostate_sscDNA 
                 0.0 
               
               
                 95012_MDA-MB-468_Breast adenocarcinoma_sscDNA 
                 0.0 
               
               
                 112196_SSC-4_Tongue_sscDNA 
                 0.0 
               
               
                 112194_SSC-9_Tongue_sscDNA 
                 0.0 
               
               
                 112191_SSC-15_Tongue_sscDNA 
                 0.0 
               
               
                 95017_CAL 27_Squamous cell carcinoma of 
                 0.0 
               
               
                 tongue_sscDNA 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag1537, Run 267177741    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ADG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 12.3 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 10.7 
               
               
                   
                 CC Margin (ODO3866) 
                 12.2 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 3.2 
               
               
                   
                 CC Margin (ODO3868) 
                 0.8 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 3.4 
               
               
                   
                 CC Margin (ODO3920) 
                 2.2 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 13.4 
               
               
                   
                 CC Margin (ODO3921) 
                 5.8 
               
               
                   
                 CC from Partial Hepatectomy (ODO4309) Mets 
                 9.6 
               
               
                   
                 Liver Margin (ODO4309) 
                 0.6 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 5.5 
               
               
                   
                 Lung Margin (OD04451-02) 
                 0.8 
               
               
                   
                 Normal Prostate 6546-1 
                 14.1 
               
               
                   
                 Prostate Cancer (OD04410) 
                 8.8 
               
               
                   
                 Prostate Margin (OD04410) 
                 6.9 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 3.1 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 10.3 
               
               
                   
                 Normal Lung 061010 
                 11.8 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 6.4 
               
               
                   
                 Muscle Margin (ODO4286) 
                 9.9 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 19.3 
               
               
                   
                 Lung Margin (OD03126) 
                 3.3 
               
               
                   
                 Lung Cancer (OD04404) 
                 5.2 
               
               
                   
                 Lung Margin (OD04404) 
                 25.3 
               
               
                   
                 Lung Cancer (OD04565) 
                 3.4 
               
               
                   
                 Lung Margin (OD04565) 
                 3.1 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 11.0 
               
               
                   
                 Lung Margin (OD04237-02) 
                 18.2 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 0.7 
               
               
                   
                 Liver Margin (ODO4310) 
                 1.7 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 3.9 
               
               
                   
                 Lung Margin (OD04321) 
                 3.7 
               
               
                   
                 Normal Kidney 
                 40.6 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 5.7 
               
               
                   
                 Kidney Margin (OD04338) 
                 11.1 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 2.5 
               
               
                   
                 Kidney Margin (OD04339) 
                 17.6 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 100.0 
               
               
                   
                 Kidney Margin (OD04340) 
                 22.7 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 55.1 
               
               
                   
                 Kidney Margin (OD04348) 
                 19.9 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 25.0 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 7.4 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 1.3 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 9.2 
               
               
                   
                 Kidney Cancer 8120607 
                 9.2 
               
               
                   
                 Kidney Margin 8120608 
                 23.5 
               
               
                   
                 Kidney Cancer 8120613 
                 21.5 
               
               
                   
                 Kidney Margin 8120614 
                 12.3 
               
               
                   
                 Kidney Cancer 9010320 
                 34.4 
               
               
                   
                 Kidney Margin 9010321 
                 27.7 
               
               
                   
                 Normal Uterus 
                 9.3 
               
               
                   
                 Uterus Cancer 064011 
                 6.4 
               
               
                   
                 Normal Thyroid 
                 84.1 
               
               
                   
                 Thyroid Cancer 064010 
                 20.6 
               
               
                   
                 Thyroid Cancer A302152 
                 15.2 
               
               
                   
                 Thyroid Margin A302153 
                 21.3 
               
               
                   
                 Normal Breast 
                 22.1 
               
               
                   
                 Breast Cancer (OD04566) 
                 8.4 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 21.0 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 27.7 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 9.1 
               
               
                   
                 Breast Cancer 064006 
                 10.1 
               
               
                   
                 Breast Cancer 1024 
                 7.1 
               
               
                   
                 Breast Cancer 9100266 
                 10.4 
               
               
                   
                 Breast Margin 9100265 
                 7.4 
               
               
                   
                 Breast Cancer A209073 
                 27.4 
               
               
                   
                 Breast Margin A209073 
                 8.7 
               
               
                   
                 Normal Liver 
                 1.1 
               
               
                   
                 Liver Cancer 064003 
                 6.5 
               
               
                   
                 Liver Cancer 1025 
                 0.7 
               
               
                   
                 Liver Cancer 1026 
                 8.1 
               
               
                   
                 Liver Cancer 6004-T 
                 1.9 
               
               
                   
                 Liver Tissue 6004-N 
                 3.6 
               
               
                   
                 Liver Cancer 6005-T 
                 9.3 
               
               
                   
                 Liver Tissue 6005-N 
                 0.6 
               
               
                   
                 Normal Bladder 
                 14.1 
               
               
                   
                 Bladder Cancer 1023 
                 4.5 
               
               
                   
                 Bladder Cancer A302173 
                 3.6 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 7.4 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 15.2 
               
               
                   
                 Normal Ovary 
                 1.4 
               
               
                   
                 Ovarian Cancer 064008 
                 6.5 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 1.6 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 9.2 
               
               
                   
                 Normal Stomach 
                 13.5 
               
               
                   
                 Gastric Cancer 9060358 
                 2.8 
               
               
                   
                 Stomach Margin 9060359 
                 12.6 
               
               
                   
                 Gastric Cancer 9060395 
                 20.6 
               
               
                   
                 Stomach Margin 9060394 
                 7.5 
               
               
                   
                 Gastric Cancer 9060397 
                 10.0 
               
               
                   
                 Stomach Margin 9060396 
                 3.2 
               
               
                   
                 Gastric Cancer 064005 
                 6.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1537, Run 145017308    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ADH 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.1 
               
               
                   
                 Secondary Th2 act 
                 0.4 
               
               
                   
                 Secondary Tr1 act 
                 0.1 
               
               
                   
                 Secondary Th1 rest 
                 0.1 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 1.2 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.2 
               
               
                   
                 CD8 lymphocyte act 
                 0.1 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.4 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.3 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.1 
               
               
                   
                 LAK cells IL-2 
                 0.1 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.2 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.5 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.2 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.2 
               
               
                   
                 NK Cells IL-2 rest 
                 0.2 
               
               
                   
                 Two Way MLR 3 day 
                 2.7 
               
               
                   
                 Two Way MLR 5 day 
                 1.3 
               
               
                   
                 Two Way MLR 7 day 
                 0.1 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.1 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.5 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.1 
               
               
                   
                 Dendritic cells none 
                 0.1 
               
               
                   
                 Dendritic cells LPS 
                 1.7 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.9 
               
               
                   
                 Monocytes rest 
                 0.6 
               
               
                   
                 Monocytes LPS 
                 0.1 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.1 
               
               
                   
                 HUVEC none 
                 1.9 
               
               
                   
                 HUVEC starved 
                 8.4 
               
               
                   
                 HUVEC IL-1beta 
                 5.6 
               
               
                   
                 HUVEC IFN gamma 
                 40.6 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 4.6 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 5.0 
               
               
                   
                 HUVEC IL-11 
                 8.7 
               
               
                   
                 Lung Microvascular EC none 
                 66.4 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 30.4 
               
               
                   
                 Microvascular Dermal EC none 
                 43.5 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 17.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.3 
               
               
                   
                 Small airway epithelium none 
                 0.0 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Coronery artery SMC rest 
                 0.0 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 1.1 
               
               
                   
                 Astrocytes rest 
                 0.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 0.2 
               
               
                   
                 KU-812 (Basophil) rest 
                 27.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 28.3 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Liver cirrhosis 
                 20.6 
               
               
                   
                 NCI-H292 none 
                 0.0 
               
               
                   
                 NCI-H292 IL-4 
                 0.0 
               
               
                   
                 NCI-H292 IL-9 
                 0.0 
               
               
                   
                 NCI-H292 IL-13 
                 0.1 
               
               
                   
                 NCI-H292 IFN gamma 
                 0.0 
               
               
                   
                 HPAEC none 
                 1.8 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 1.5 
               
               
                   
                 Lung fibroblast none 
                 0.4 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.6 
               
               
                   
                 Lung fibroblast IL-4 
                 0.2 
               
               
                   
                 Lung fibroblast IL-9 
                 0.0 
               
               
                   
                 Lung fibroblast IL-13 
                 0.4 
               
               
                   
                 Lung fibroblast IFN gamma 
                 0.2 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 1.1 
               
               
                   
                 Dermal fibroblast IL-4 
                 0.4 
               
               
                   
                 Dermal Fibroblasts rest 
                 0.7 
               
               
                   
                 Neutrophils TNFa + LPS 
                 0.4 
               
               
                   
                 Neutrophils rest 
                 0.3 
               
               
                   
                 Colon 
                 19.3 
               
               
                   
                 Lung 
                 100.0 
               
               
                   
                 Thymus 
                 48.0 
               
               
                   
                 Kidney 
                 68.8 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag4932, Run 223597251    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ADI 
               
             
            
               
                   
               
               
                   
               
               
                 general oncology screening panel_v_2.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Colon cancer 1 
                 11.4 
               
               
                   
                 Colon cancer NAT 1 
                 9.4 
               
               
                   
                 Colon cancer 2 
                 4.1 
               
               
                   
                 Colon cancer NAT 2 
                 4.1 
               
               
                   
                 Colon cancer 3 
                 10.4 
               
               
                   
                 Colon cancer NAT 3 
                 7.6 
               
               
                   
                 Colon malignant cancer 4 
                 9.7 
               
               
                   
                 Colon normal adjacent tissue 4 
                 3.4 
               
               
                   
                 Lung cancer 1 
                 4.8 
               
               
                   
                 Lung NAT 1 
                 0.7 
               
               
                   
                 Lung cancer 2 
                 5.6 
               
               
                   
                 Lung NAT 2 
                 0.1 
               
               
                   
                 Squamous cell carcinoma 3 
                 5.4 
               
               
                   
                 Lung NAT 3 
                 0.7 
               
               
                   
                 metastatic melanoma 1 
                 1.5 
               
               
                   
                 Melanoma 2 
                 4.0 
               
               
                   
                 Melanoma 3 
                 3.8 
               
               
                   
                 metastatic melanoma 4 
                 2.2 
               
               
                   
                 metastatic melanoma 5 
                 4.6 
               
               
                   
                 Bladder cancer 1 
                 1.0 
               
               
                   
                 Bladder cancer NAT 1 
                 0.0 
               
               
                   
                 Bladder cancer 2 
                 4.4 
               
               
                   
                 Bladder cancer NAT 2 
                 0.6 
               
               
                   
                 Bladder cancer NAT 3 
                 0.8 
               
               
                   
                 Bladder cancer NAT 4 
                 4.2 
               
               
                   
                 Prostate adenocarcinoma 1 
                 2.1 
               
               
                   
                 Prostate adenocarcinoma 2 
                 1.2 
               
               
                   
                 Prostate adenocarcinoma 3 
                 2.1 
               
               
                   
                 Prostate adenocarcinoma 4 
                 6.0 
               
               
                   
                 Prostate cancer NAT 5 
                 3.0 
               
               
                   
                 Prostate adenocarcinoma 6 
                 1.3 
               
               
                   
                 Prostate adenocarcinoma 7 
                 1.2 
               
               
                   
                 Prostate adenocarcinoma 8 
                 1.2 
               
               
                   
                 Prostate adenocarcinoma 9 
                 4.8 
               
               
                   
                 Prostate cancer NAT 10 
                 0.6 
               
               
                   
                 Kidney cancer 1 
                 90.1 
               
               
                   
                 Kidney NAT 1 
                 5.0 
               
               
                   
                 Kidney cancer 2 
                 60.3 
               
               
                   
                 Kidney NAT 2 
                 9.8 
               
               
                   
                 Kidney cancer 3 
                 30.8 
               
               
                   
                 Kidney NAT 3 
                 5.4 
               
               
                   
                 Kidney cancer 4 
                 100.0 
               
               
                   
                 Kidney NAT 4 
                 6.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1537, Run 266930996    
               
            
           
         
       
     
      Ardais Kidney 1.0 Summary: Ag1537 Highest expression was seen in a kidney cancer sample (CT=21.3). In addition, this gene was more highly expressed in kidney cancer than in the corresponding normal adjacent tissue. Expression of this gene is useful as a marker of these cancers. Therapeutic modulation of the expression or function of this gene or gene product is useful in the treatment of kidney cancer.  
      Ardais Panel v.1.0 Summary: Ag1537 Highest expression of this gene was detected in a normal lung sample (CT=26.7). High to moderate levels of expression are seen in both malignant and normal lung samples. Therapeutic modulation of the PV1 protein (PLVAP) encoded by this gene is useful in the treatment of certain subtypes of lung cancer.  
      General_screening 13  panel_v1.5 Summary: Ag4932 Highest expression of this gene was detected in the spleen (CT=26). High levels of expression of this gene were also detected in tissues with metabolic/endocrine functions including pancreas, adipose, adrenal gland, thyroid, pituitary gland, skeletal muscle, heart, liver and the gastrointestinal tract. The PV-1-like protein is a plasma membrane protein with an extracellular domain that is an antibody target for the treatment of endocrine/metabolically related diseases, such as obesity and diabetes.  
      Moderate levels of expression of this gene were also seen in all regions of the central nervous system examined, including amygdala, hippocampus, substantia nigra, thalamus, cerebellum, cerebral cortex, and spinal cord. Therapeutic modulation of this gene or gene product is useful in the treatment of central nervous system disorders such as Alzheimer&#39;s disease, Parkinson&#39;s disease, epilepsy, multiple sclerosis, schizophrenia and depression.  
      In addition, this gene also showed high expression in colon cancer tissue, with moderate levels of expression in a gastric NCI-N87 cell line. Therapeutic modulation of this gene is useful in the treatment of colon and gastric cancers.  
      Oncology 13  cell 13  line_screening 13  panel_v3.2 Summary: Ag1537 Highest expression of this gene was detected in TF-1 erythroleukemia cells (CT=28.6). Moderate levels of expression of this gene are restricted to erythroleukemia and myelogenous leukemia. Expression of this gene is useful as a marker to distinguish these leukemia samples from other samples in the panel and also, as marker to detect the presence of these leukemia. Therapeutic modulation of this gene or its protein product is useful in the treatment of erythroleukemia and myelogenous leukemia.  
      Panel 2D Summary: Ag1537 Expression of this gene was highest in a kidney cancer (OD04340) sample (CT=25). This gene was widely expressed across this panel with high to moderate expression in both normal and adjacent cancer tissue. This gene was more highly expressed in kidney cancer tissue than in adjacent normal tissue, consistent with expression pattern seen in panel 2.4. This gene is useful as a marker to distinguish kidney cancers from normal kidney tissue. Therapeutic modulation of this gene or its protein product, through the use of small molecule drugs or antibodies, is of benefit in the treatment of kidney cancer.  
      Panel 4.1D Summary: Ag4932 Highest expression of this gene was detected in the lung (CT=28.5). Moderate levels of expression of this gene were also seen in endothelial cells, basophils and normal tissues represented by colon, thymus and kidney. This gene codes for a variant of PV-1, a component of the endothelial fenestral and stomatal diaphragms. Antibodies raised against the PV-1 encoded by this gene are useful in preventing transendothelial trafficking of inflammatory cells to different tissues sites and as a treatment of inflammatory diseases including delayed type hypersensitivity, asthma, emphysema, rheumatoid arthritis and IBD.  
      Moderate levels of expression of this gene were also seen in liver cirrhosis samples. Therefore, targeting this gene or its protein product with protein therapeutics, antibodies or small molecule therapeutics is useful as a treatment to reduce or inhibit fibrosis that occurs in liver cirrhosis.  
      general oncology screening panel_v — 2.4 Summary: Ag1537/Ag760 Highest expression of this gene was seen in a kidney cancer sample (CTs=22.6-25). Significant expression of this gene was seen in melanoma, colon, lung, prostate, bladder and kidney cancer as well as normal tissue samples. Expression of this gene was higher in kidney cancer as compared to corresponding normal control samples. Expression of this gene is useful as a marker to distinguish kidney cancer from normal tissue and also as a marker to detect kidney cancer. Therapeutic modulation of this gene or its protein product through the use of antibodies, protein therapeutics or small molecule drug is useful in the treatment of melanoma, kidney, colon, lung and prostate cancers.  
      AE. CG5525607: Apolipoprotein E Receptor 2  
      Expression of gene CG55256-07 was assessed using the primer-probe set Ag6829, described in Table AEA. Results of the RTQ-PCR runs are shown in Tables AEB and AEC.  
               TABLE AEA                          Probe Name Ag6829                                                 Start   SEQ ID           Primers   Sequences   Length   Position   No               Forward   5′-aggacatgctgtggatgaag-3′   20   3987   1411                   Probe   TET-5′-tcacatctcttatttctcttttcccctt-3′-   28   4031   1412           TAMRA               Reverse   5′-ccccacataaaggaaatggt-3′   20   4066   1413                  
 
     
       
         
           
               
             
               
                 TABLE AEB 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.7 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 1.5 
               
               
                   
                 HUVEC 
                 3.6 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 4.5 
               
               
                   
                 Melanoma (met) SK-MEL-5 
                 5.7 
               
               
                   
                 Testis 
                 4.8 
               
               
                   
                 Prostate ca. (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate ca. DU145 
                 5.0 
               
               
                   
                 Prostate pool 
                 0.1 
               
               
                   
                 Uterus pool 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 1.9 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 0.1 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 13.3 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 13.2 
               
               
                   
                 Ovarian ca. IGROV-1 
                 29.9 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 13.9 
               
               
                   
                 Ovary 
                 0.4 
               
               
                   
                 Breast ca. MCF-7 
                 3.2 
               
               
                   
                 Breast ca. MDA-MB-231 
                 12.7 
               
               
                   
                 Breast ca. BT-549 
                 3.2 
               
               
                   
                 Breast ca. T47D 
                 1.5 
               
               
                   
                 Breast pool 
                 0.0 
               
               
                   
                 Trachea 
                 1.4 
               
               
                   
                 Lung 
                 1.3 
               
               
                   
                 Fetal Lung 
                 1.4 
               
               
                   
                 Lung ca. NCI-N417 
                 2.2 
               
               
                   
                 Lung ca. LX-1 
                 1.9 
               
               
                   
                 Lung ca. NCI-H146 
                 3.8 
               
               
                   
                 Lung ca. SHP-77 
                 40.9 
               
               
                   
                 Lung ca. NCI-H23 
                 8.1 
               
               
                   
                 Lung ca. NCI-H460 
                 46.3 
               
               
                   
                 Lung ca. HOP-62 
                 15.3 
               
               
                   
                 Lung ca. NCI-H522 
                 9.2 
               
               
                   
                 Lung ca. DMS-114 
                 1.4 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 0.1 
               
               
                   
                 Kidney pool 
                 0.8 
               
               
                   
                 Fetal Kidney 
                 0.1 
               
               
                   
                 Renal ca. 786-0 
                 15.6 
               
               
                   
                 Renal ca. A498 
                 1.0 
               
               
                   
                 Renal ca. ACHN 
                 4.2 
               
               
                   
                 Renal ca. UO-31 
                 1.1 
               
               
                   
                 Renal ca. TK-10 
                 7.6 
               
               
                   
                 Bladder 
                 0.2 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 1.3 
               
               
                   
                 Stomach 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 2.6 
               
               
                   
                 Colon ca. SW480 
                 1.1 
               
               
                   
                 Colon ca. (SW480 met) SW620 
                 14.4 
               
               
                   
                 Colon ca. HT29 
                 100.0 
               
               
                   
                 Colon ca. HCT-116 
                 30.6 
               
               
                   
                 Colon cancer tissue 
                 0.0 
               
               
                   
                 Colon ca. SW1116 
                 7.6 
               
               
                   
                 Colon ca. Colo-205 
                 4.4 
               
               
                   
                 Colon ca. SW-48 
                 1.8 
               
               
                   
                 Colon 
                 0.1 
               
               
                   
                 Small Intestine 
                 0.0 
               
               
                   
                 Fetal Heart 
                 0.0 
               
               
                   
                 Heart 
                 0.0 
               
               
                   
                 Lymph Node pool 1 
                 0.0 
               
               
                   
                 Lymph Node pool 2 
                 3.3 
               
               
                   
                 Fetal Skeletal Muscle 
                 0.1 
               
               
                   
                 Skeletal Muscle pool 
                 0.0 
               
               
                   
                 Skeletal Muscle 
                 0.0 
               
               
                   
                 Spleen 
                 0.2 
               
               
                   
                 Thymus 
                 0.1 
               
               
                   
                 CNS cancer (glio/astro) SF-268 
                 3.0 
               
               
                   
                 CNS cancer (glio/astro) T98G 
                 5.7 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.6 
               
               
                   
                 CNS cancer (astro) SF-539 
                 10.5 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 9.3 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 23.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 3.1 
               
               
                   
                 Brain (Amygdala) 
                 3.4 
               
               
                   
                 Brain (Cerebellum) 
                 4.5 
               
               
                   
                 Brain (Fetal) 
                 24.0 
               
               
                   
                 Brain (Hippocampus) 
                 1.9 
               
               
                   
                 Cerebral Cortex pool 
                 2.5 
               
               
                   
                 Brain (Substantia nigra) 
                 1.2 
               
               
                   
                 Brain (Thalamus) 
                 3.3 
               
               
                   
                 Brain (Whole) 
                 21.9 
               
               
                   
                 Spinal Cord 
                 0.5 
               
               
                   
                 Adrenal Gland 
                 0.3 
               
               
                   
                 Pituitary Gland 
                 2.4 
               
               
                   
                 Salivary Gland 
                 0.1 
               
               
                   
                 Thyroid 
                 13.9 
               
               
                   
                 Pancreatic ca. PANC-1 
                 1.2 
               
               
                   
                 Pancreas pool 
                 0.1 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag6829, Run 318350033    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AEC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 5 Islet 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 97457_Patient-02go_adipose 
                 0.0 
               
               
                   
                 97476_Patient-07sk_skeletal muscle 
                 0.0 
               
               
                   
                 97477_Patient-07ut_uterus 
                 0.0 
               
               
                   
                 97478_Patient-07pl_placenta 
                 21.2 
               
               
                   
                 99167_Bayer Patient 1 
                 2.4 
               
               
                   
                 97482_Patient-08ut_uterus 
                 0.0 
               
               
                   
                 97483_Patient-08pl_placenta 
                 10.7 
               
               
                   
                 97486_Patient-09sk_skeletal muscle 
                 0.0 
               
               
                   
                 97487_Patient-09ut_uterus 
                 0.0 
               
               
                   
                 97488_Patient-09pl_placenta 
                 12.2 
               
               
                   
                 97492_Patient-10ut_uterus 
                 0.0 
               
               
                   
                 97493_Patient-10pl_placenta 
                 63.7 
               
               
                   
                 97495_Patient-11go_adipose 
                 0.0 
               
               
                   
                 97496_Patient-11sk_skeletal muscle 
                 0.0 
               
               
                   
                 97497_Patient-11ut_uterus 
                 4.3 
               
               
                   
                 97498_Patient-11pl_placenta 
                 15.9 
               
               
                   
                 97500_Patient-12go_adipose 
                 0.0 
               
               
                   
                 97501_Patient-12sk_skeletal muscle 
                 2.9 
               
               
                   
                 97502_Patient-12ut_uterus 
                 5.4 
               
               
                   
                 97503_Patient-12pl_placenta 
                 62.4 
               
               
                   
                 94721_Donor 2 U - A_Mesenchymal Stem Cells 
                 7.4 
               
               
                   
                 94722_Donor 2 U - B_Mesenchymal Stem Cells 
                 5.9 
               
               
                   
                 94723_Donor 2 U - C_Mesenchymal Stem Cells 
                 6.7 
               
               
                   
                 94709_Donor 2 AM - A_adipose 
                 11.9 
               
               
                   
                 94710_Donor 2 AM - B_adipose 
                 5.0 
               
               
                   
                 94711_Donor 2 AM - C_adipose 
                 4.5 
               
               
                   
                 94712_Donor 2 AD - A_adipose 
                 7.5 
               
               
                   
                 94713_Donor 2 AD - B_adipose 
                 17.6 
               
               
                   
                 94714_Donor 2 AD - C_adipose 
                 8.4 
               
               
                   
                 94742_Donor 3 U - A_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94743_Donor 3 U - B_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94730_Donor 3 AM - A_adipose 
                 19.8 
               
               
                   
                 94731_Donor 3 AM - B_adipose 
                 37.9 
               
               
                   
                 94732_Donor 3 AM - C_adipose 
                 29.9 
               
               
                   
                 94733_Donor 3 AD - A_adipose 
                 32.5 
               
               
                   
                 94734_Donor 3 AD - B_adipose 
                 17.2 
               
               
                   
                 94735_Donor 3 AD - C_adipose 
                 18.9 
               
               
                   
                 77138_Liver_HepG2untreated 
                 100.0 
               
               
                   
                 73556_Heart_Cardiac stromal cells (primary) 
                 4.9 
               
               
                   
                 81735_Small Intestine 
                 2.6 
               
               
                   
                 72409_Kidney_Proximal Convoluted Tubule 
                 29.5 
               
               
                   
                 82685_Small intestine_Duodenum 
                 0.0 
               
               
                   
                 90650_Adrenal_Adrenocortical adenoma 
                 0.0 
               
               
                   
                 72410_Kidney_HRCE 
                 67.8 
               
               
                   
                 72411_Kidney_HRE 
                 37.6 
               
               
                   
                 73139_Uterus_Uterine smooth muscle cells 
                 15.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag6829, Run 279524965    
               
            
           
         
       
     
      General_screening 13  panel 13  v1.7 Summary: Ag6829 Highest expression was seen in a colon cancer cell line (CT=28). Prominent levels of expression were seen in clusters of cell lines derived from brain, colon, lung and ovarian cancer cell lines. Targeting this gene or its protein product is useful in the treatment of these cancers.  
      Panel 5 Islet Summary: Ag6829 Low but significant levels of expression were seen in a liver cell line (CT=34).  
      AF. CG5525610: Apolipoprotein E Receptor 2  
      Expression of full-length physical clone CG55256-10 was assessed using the primer-probe set Ag7103, described in Table AFA. Results of the RTQ-PCR runs are shown in Table AFB.  
               TABLE AFA                          Probe Name Ag7103                                                 Start   SEQ ID           Primers   Sequences   Length   Position   No               Forward   5′-cccagcttctctgcacca-3′   18   778   1414                   Probe   TET-5′-cctcggactcatcggagccatca-3′-   23   818   1415           TAMRA               Reverse   5′-cggcgaggaggagtgtc-3′   17   842   1416                  
 
     
       
         
           
               
             
               
                 TABLE AFB 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.7 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 1.2 
               
               
                   
                 HUVEC 
                 4.6 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 6.3 
               
               
                   
                 Melanoma (met) SK-MEL-5 
                 7.8 
               
               
                   
                 Testis 
                 9.2 
               
               
                   
                 Prostate ca. (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate ca. DU145 
                 13.7 
               
               
                   
                 Prostate pool 
                 0.1 
               
               
                   
                 Uterus pool 
                 0.1 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.9 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 0.7 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 11.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 10.4 
               
               
                   
                 Ovarian ca. IGROV-1 
                 19.6 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 8.6 
               
               
                   
                 Ovary 
                 0.5 
               
               
                   
                 Breast ca. MCF-7 
                 6.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 12.2 
               
               
                   
                 Breast ca. BT-549 
                 4.9 
               
               
                   
                 Breast ca. T47D 
                 3.6 
               
               
                   
                 Breast pool 
                 0.1 
               
               
                   
                 Trachea 
                 1.3 
               
               
                   
                 Lung 
                 1.0 
               
               
                   
                 Fetal Lung 
                 1.3 
               
               
                   
                 Lung ca. NCI-N417 
                 7.2 
               
               
                   
                 Lung ca. LX-1 
                 6.7 
               
               
                   
                 Lung ca. NCI-H146 
                 5.9 
               
               
                   
                 Lung ca. SHP-77 
                 18.7 
               
               
                   
                 Lung ca. NCI-H23 
                 7.9 
               
               
                   
                 Lung ca. NCI-H460 
                 26.4 
               
               
                   
                 Lung ca. HOP-62 
                 9.9 
               
               
                   
                 Lung ca. NCI-H522 
                 7.1 
               
               
                   
                 Lung ca. DMS-114 
                 2.5 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 0.2 
               
               
                   
                 Kidney pool 
                 0.5 
               
               
                   
                 Fetal Kidney 
                 0.3 
               
               
                   
                 Renal ca. 786-0 
                 11.0 
               
               
                   
                 Renal ca. A498 
                 3.2 
               
               
                   
                 Renal ca. ACHN 
                 4.3 
               
               
                   
                 Renal ca. UO-31 
                 1.7 
               
               
                   
                 Renal ca. TK-10 
                 9.9 
               
               
                   
                 Bladder 
                 0.5 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 2.6 
               
               
                   
                 Stomach 
                 0.1 
               
               
                   
                 Colon ca. SW-948 
                 2.7 
               
               
                   
                 Colon ca. SW480 
                 4.9 
               
               
                   
                 Colon ca. (SW480 met) SW620 
                 15.5 
               
               
                   
                 Colon ca. HT29 
                 64.6 
               
               
                   
                 Colon ca. HCT-116 
                 24.0 
               
               
                   
                 Colon cancer tissue 
                 0.2 
               
               
                   
                 Colon ca. SW1116 
                 19.1 
               
               
                   
                 Colon ca. Colo-205 
                 8.2 
               
               
                   
                 Colon ca. SW-48 
                 3.6 
               
               
                   
                 Colon 
                 0.3 
               
               
                   
                 Small Intestine 
                 0.0 
               
               
                   
                 Fetal Heart 
                 0.1 
               
               
                   
                 Heart 
                 0.1 
               
               
                   
                 Lymph Node pool 1 
                 0.1 
               
               
                   
                 Lymph Node pool 2 
                 2.2 
               
               
                   
                 Fetal Skeletal Muscle 
                 0.3 
               
               
                   
                 Skeletal Muscle pool 
                 0.0 
               
               
                   
                 Skeletal Muscle 
                 0.1 
               
               
                   
                 Spleen 
                 0.3 
               
               
                   
                 Thymus 
                 0.5 
               
               
                   
                 CNS cancer (glio/astro) SF-268 
                 5.3 
               
               
                   
                 CNS cancer (glio/astro) T98G 
                 8.4 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 100.0 
               
               
                   
                 CNS cancer (astro) SF-539 
                 9.7 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 10.2 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 18.4 
               
               
                   
                 CNS cancer (glio) SF-295 
                 6.8 
               
               
                   
                 Brain (Amygdala) 
                 5.0 
               
               
                   
                 Brain (Cerebellum) 
                 11.3 
               
               
                   
                 Brain (Fetal) 
                 27.5 
               
               
                   
                 Brain (Hippocampus) 
                 3.6 
               
               
                   
                 Cerebral Cortex pool 
                 3.3 
               
               
                   
                 Brain (Substantia nigra) 
                 3.0 
               
               
                   
                 Brain (Thalamus) 
                 3.6 
               
               
                   
                 Brain (Whole) 
                 22.5 
               
               
                   
                 Spinal Cord 
                 0.8 
               
               
                   
                 Adrenal Gland 
                 0.7 
               
               
                   
                 Pituitary Gland 
                 4.3 
               
               
                   
                 Salivary Gland 
                 0.1 
               
               
                   
                 Thyroid 
                 11.9 
               
               
                   
                 Pancreatic ca. PANC-1 
                 3.1 
               
               
                   
                 Pancreas pool 
                 0.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag7103, Run 318037113    
               
            
           
         
       
     
      General_screening 13  panel_v1.7 Summary: Ag7103 Highest expression was seen in a brain cancer cell line (CT=21), with high levels of expression seen in all the cancer cell line samples on this panel. This gene or gene product is involved in cell growth and/or proliferation. Targeting this gene or gene product is useful in the treatment of cancers, including breast, brain, ovarian, colon, renal, brain, prostate and melanoma cancers.  
      AG. CG5577601: Mechanical Stress Induced Protein  
      Expression of gene CG55776-01 was assessed using the primer-probe sets Ag1489 and Ag4335, described in Tables AGA and AGB. Results of the RTQ-PCR runs are shown in Tables AGC, AGD, AGE, AGF, AGG and AGH.  
               TABLE AGA                          Probe Name Ag1489                                                 Start   SEQ ID           Primers   Sequences   Length   Position   No               Forward   5′-cacagcattgaattgctctgt-3′   21   7049   1417                   Probe   TET-5′-tctggattttaccaaatggcacacga-3′-   26   7096   1418           TAMRA               Reverse   5′-gataactttgtggtccattgga-3′   22   7125   1419                  
 
     
       
         
           
               
             
               
                 TABLE AGB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag4335 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-cacctgaagaacccacagatt-3′ 
                 21 
                 2593 
                 1420 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-tgctattaaaactacagccatgtcaaaga-3′- 
                 29 
                 2627 
                 1421 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-gcttgacatggttgggtttat-3′ 
                 21 
                 2658 
                 1422 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AGC 
               
             
            
               
                   
               
               
                   
               
               
                 AI_comprehensive panel_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 110967 COPD-F 
                 1.8 
               
               
                   
                 110980 COPD-F 
                 12.1 
               
               
                   
                 110968 COPD-M 
                 2.7 
               
               
                   
                 110977 COPD-M 
                 0.0 
               
               
                   
                 110989 Emphysema-F 
                 4.9 
               
               
                   
                 110992 Emphysema-F 
                 5.7 
               
               
                   
                 110993 Emphysema-F 
                 3.3 
               
               
                   
                 110994 Emphysema-F 
                 1.7 
               
               
                   
                 110995 Emphysema-F 
                 5.2 
               
               
                   
                 110996 Emphysema-F 
                 3.1 
               
               
                   
                 110997 Asthma-M 
                 0.5 
               
               
                   
                 111001 Asthma-F 
                 2.2 
               
               
                   
                 111002 Asthma-F 
                 2.3 
               
               
                   
                 111003 Atopic Asthma-F 
                 2.3 
               
               
                   
                 111004 Atopic Asthma-F 
                 6.1 
               
               
                   
                 111005 Atopic Asthma-F 
                 2.6 
               
               
                   
                 111006 Atopic Asthma-F 
                 0.4 
               
               
                   
                 111417 Allergy-M 
                 3.4 
               
               
                   
                 112347 Allergy-M 
                 0.1 
               
               
                   
                 112349 Normal Lung-F 
                 0.2 
               
               
                   
                 112357 Normal Lung-F 
                 100.0 
               
               
                   
                 112354 Normal Lung-M 
                 59.0 
               
               
                   
                 112374 Crohns-F 
                 7.3 
               
               
                   
                 112389 Match Control Crohns-F 
                 0.5 
               
               
                   
                 112375 Crohns-F 
                 4.4 
               
               
                   
                 112732 Match Control Crohns-F 
                 6.1 
               
               
                   
                 112725 Crohns-M 
                 0.9 
               
               
                   
                 112387 Match Control Crohns-M 
                 2.5 
               
               
                   
                 112378 Crohns-M 
                 0.4 
               
               
                   
                 112390 Match Control Crohns-M 
                 7.5 
               
               
                   
                 112726 Crohns-M 
                 2.3 
               
               
                   
                 112731 Match Control Crohns-M 
                 4.7 
               
               
                   
                 112380 Ulcer Col-F 
                 2.4 
               
               
                   
                 112734 Match Control Ulcer Col-F 
                 24.1 
               
               
                   
                 112384 Ulcer Col-F 
                 4.6 
               
               
                   
                 112737 Match Control Ulcer Col-F 
                 1.6 
               
               
                   
                 112386 Ulcer Col-F 
                 1.7 
               
               
                   
                 112738 Match Control Ulcer Col-F 
                 3.2 
               
               
                   
                 112381 Ulcer Col-M 
                 0.8 
               
               
                   
                 112735 Match Control Ulcer Col-M 
                 3.8 
               
               
                   
                 112382 Ulcer Col-M 
                 1.0 
               
               
                   
                 112394 Match Control Ulcer Col-M 
                 1.9 
               
               
                   
                 112383 Ulcer Col-M 
                 4.0 
               
               
                   
                 112736 Match Control Ulcer Col-M 
                 0.6 
               
               
                   
                 112423 Psoriasis-F 
                 8.9 
               
               
                   
                 112427 Match Control Psoriasis-F 
                 28.5 
               
               
                   
                 112418 Psoriasis-M 
                 2.1 
               
               
                   
                 112723 Match Control Psoriasis-M 
                 6.9 
               
               
                   
                 112419 Psoriasis-M 
                 4.2 
               
               
                   
                 112424 Match Control Psoriasis-M 
                 4.4 
               
               
                   
                 112420 Psoriasis-M 
                 5.4 
               
               
                   
                 112425 Match Control Psoriasis-M 
                 33.2 
               
               
                   
                 104689 (MF) OA Bone-Backus 
                 9.0 
               
               
                   
                 104690 (MF) Adj “Normal” Bone-Backus 
                 8.1 
               
               
                   
                 104691 (MF) OA Synovium-Backus 
                 54.0 
               
               
                   
                 104692 (BA) OA Cartilage-Backus 
                 0.3 
               
               
                   
                 104694 (BA) OA Bone-Backus 
                 20.3 
               
               
                   
                 104695 (BA) Adj “Normal” Bone-Backus 
                 3.1 
               
               
                   
                 104696 (BA) OA Synovium-Backus 
                 26.4 
               
               
                   
                 104700 (SS) OA Bone-Backus 
                 2.8 
               
               
                   
                 104701 (SS) Adj “Normal” Bone-Backus 
                 8.6 
               
               
                   
                 104702 (SS) OA Synovium-Backus 
                 14.7 
               
               
                   
                 117093 OA Cartilage Rep7 
                 2.1 
               
               
                   
                 112672 OA Bone5 
                 11.9 
               
               
                   
                 112673 OA Synovium5 
                 5.8 
               
               
                   
                 112674 OA Synovial Fluid cells5 
                 6.4 
               
               
                   
                 117100 OA Cartilage Rep14 
                 0.7 
               
               
                   
                 112756 OA Bone9 
                 2.8 
               
               
                   
                 112757 OA Synovium9 
                 0.8 
               
               
                   
                 112758 OA Synovial Fluid Cells9 
                 6.1 
               
               
                   
                 117125 RA Cartilage Rep2 
                 3.4 
               
               
                   
                 113492 Bone2 RA 
                 40.3 
               
               
                   
                 113493 Synovium2 RA 
                 15.8 
               
               
                   
                 113494 Syn Fluid Cells RA 
                 25.2 
               
               
                   
                 113499 Cartilage4 RA 
                 33.9 
               
               
                   
                 113500 Bone4 RA 
                 42.6 
               
               
                   
                 113501 Synovium4 RA 
                 26.6 
               
               
                   
                 113502 Syn Fluid Cells4 RA 
                 20.0 
               
               
                   
                 113495 Cartilage3 RA 
                 27.2 
               
               
                   
                 113496 Bone3 RA 
                 32.8 
               
               
                   
                 113497 Synovium3 RA 
                 19.3 
               
               
                   
                 113498 Syn Fluid Cells3 RA 
                 39.5 
               
               
                   
                 117106 Normal Cartilage Rep20 
                 0.0 
               
               
                   
                 113663 Bone3 Normal 
                 0.7 
               
               
                   
                 113664 Synovium3 Normal 
                 0.1 
               
               
                   
                 113665 Syn Fluid Cells3 Normal 
                 0.3 
               
               
                   
                 117107 Normal Cartilage Rep22 
                 2.2 
               
               
                   
                 113667 Bone4 Normal 
                 4.1 
               
               
                   
                 113668 Synovium4 Normal 
                 4.8 
               
               
                   
                 113669 Syn Fluid Cells4 Normal 
                 5.8 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1489, Run 226203351    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AGD 
               
             
            
               
                   
               
               
                   
               
               
                 Ardais Panel 1.1 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Lung adenocarcinoma SI A 
                 2.0 
               
               
                   
                 Lung adenocarcinoma SI B 
                 4.2 
               
               
                   
                 Lung adenocarcinoma SI B NAT 
                 78.5 
               
               
                   
                 Lung adenocarcinoma SI C 
                 0.1 
               
               
                   
                 Lung adenocarcinoma SI C NAT 
                 52.1 
               
               
                   
                 Lung adenocarcinoma SII A 
                 1.6 
               
               
                   
                 Lung adenocarcinoma SII A NAT 
                 69.7 
               
               
                   
                 Lung adenocarcinoma SII C NAT 
                 100.0 
               
               
                   
                 Lung adenocarcinoma SIII A 
                 2.3 
               
               
                   
                 Lung adenocarcinoma SIII B 
                 1.6 
               
               
                   
                 Lung adenocarcinoma SIII C 
                 0.0 
               
               
                   
                 Lung SCC SI A 
                 1.3 
               
               
                   
                 Lung SCC SI B NAT 
                 61.6 
               
               
                   
                 Lung SCC SI C 
                 14.5 
               
               
                   
                 Lung SCC SI C NAT 
                 23.0 
               
               
                   
                 Lung SCC SI D 
                 11.8 
               
               
                   
                 Lung SCC SI D NAT 
                 16.6 
               
               
                   
                 Lung SCC SII A 
                 79.6 
               
               
                   
                 Lung SCC SII B 
                 0.7 
               
               
                   
                 Lung SCC SIII A 
                 0.9 
               
               
                   
                 Lung SCC SIII A NAT 
                 18.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1489, Run 312115281    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AGE 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 4.7 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.2 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.4 
               
               
                   
                 Melanoma* M14 
                 0.1 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.1 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.2 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.3 
               
               
                   
                 Testis Pool 
                 1.5 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.3 
               
               
                   
                 Prostate Pool 
                 0.2 
               
               
                   
                 Placenta 
                 0.1 
               
               
                   
                 Uterus Pool 
                 1.5 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 1.1 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.2 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.1 
               
               
                   
                 Ovary 
                 3.8 
               
               
                   
                 Breast ca. MCF-7 
                 0.7 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.1 
               
               
                   
                 Breast ca. BT 549 
                 0.2 
               
               
                   
                 Breast ca. T47D 
                 0.3 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Breast Pool 
                 2.1 
               
               
                   
                 Trachea 
                 7.0 
               
               
                   
                 Lung 
                 8.5 
               
               
                   
                 Fetal Lung 
                 100.0 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 10.7 
               
               
                   
                 Lung ca. SHP-77 
                 0.1 
               
               
                   
                 Lung ca. A549 
                 3.3 
               
               
                   
                 Lung ca. NCI-H526 
                 0.2 
               
               
                   
                 Lung ca. NCI-H23 
                 3.3 
               
               
                   
                 Lung ca. NCI-H460 
                 0.1 
               
               
                   
                 Lung ca. HOP-62 
                 2.6 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
               
               
                   
                 Liver 
                 0.1 
               
               
                   
                 Fetal Liver 
                 0.6 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
               
               
                   
                 Kidney Pool 
                 8.0 
               
               
                   
                 Fetal Kidney 
                 1.6 
               
               
                   
                 Renal ca. 786-0 
                 0.3 
               
               
                   
                 Renal ca. A498 
                 0.2 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Bladder 
                 0.5 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.2 
               
               
                   
                 Gastric ca. KATO III 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.1 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 1.8 
               
               
                   
                 Colon ca. HCT-116 
                 0.1 
               
               
                   
                 Colon ca. CaCo-2 
                 3.8 
               
               
                   
                 Colon cancer tissue 
                 0.3 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 2.0 
               
               
                   
                 Small Intestine Pool 
                 4.2 
               
               
                   
                 Stomach Pool 
                 1.5 
               
               
                   
                 Bone Marrow Pool 
                 1.1 
               
               
                   
                 Fetal Heart 
                 4.9 
               
               
                   
                 Heart Pool 
                 2.7 
               
               
                   
                 Lymph Node Pool 
                 2.2 
               
               
                   
                 Fetal Skeletal Muscle 
                 8.2 
               
               
                   
                 Skeletal Muscle Pool 
                 0.3 
               
               
                   
                 Spleen Pool 
                 2.2 
               
               
                   
                 Thymus Pool 
                 2.1 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.3 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 0.4 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.0 
               
               
                   
                 CNS cancer (astro) SF-539 
                 3.9 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 10.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 4.0 
               
               
                   
                 Brain (Amygdala) Pool 
                 0.5 
               
               
                   
                 Brain (cerebellum) 
                 0.3 
               
               
                   
                 Brain (fetal) 
                 0.4 
               
               
                   
                 Brain (Hippocampus) Pool 
                 1.6 
               
               
                   
                 Cerebral Cortex Pool 
                 1.1 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 0.5 
               
               
                   
                 Brain (Thalamus) Pool 
                 1.4 
               
               
                   
                 Brain (whole) 
                 0.6 
               
               
                   
                 Spinal Cord Pool 
                 0.7 
               
               
                   
                 Adrenal Gland 
                 3.8 
               
               
                   
                 Pituitary gland Pool 
                 3.0 
               
               
                   
                 Salivary Gland 
                 1.7 
               
               
                   
                 Thyroid (female) 
                 1.0 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.0 
               
               
                   
                 Pancreas Pool 
                 2.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag4335, Run 222550589    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AGF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Normal Colon 
                 24.0 
                 17.2 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 1.4 
                 0.4 
               
               
                   
                 CC Margin (ODO3866) 
                 4.6 
                 3.6 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 0.4 
                 0.7 
               
               
                   
                 CC Margin (ODO3868) 
                 3.4 
                 1.1 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 0.0 
                 0.1 
               
               
                   
                 CC Margin (ODO3920) 
                 5.0 
                 4.7 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 1.0 
                 0.5 
               
               
                   
                 CC Margin (ODO3921) 
                 4.1 
                 5.0 
               
               
                   
                 CC from Partial Hepatectomy 
                 2.2 
                 0.9 
               
               
                   
                 (ODO4309) Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 3.2 
                 2.0 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 0.4 
                 0.7 
               
               
                   
                 Lung Margin (OD04451-02) 
                 6.0 
                 5.2 
               
               
                   
                 Normal Prostate 6546-1 
                 1.1 
                 0.9 
               
               
                   
                 Prostate Cancer (OD04410) 
                 1.4 
                 0.6 
               
               
                   
                 Prostate Margin (OD04410) 
                 0.2 
                 0.7 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 0.9 
                 0.6 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 1.0 
                 1.0 
               
               
                   
                 Normal Lung 061010 
                 100.0 
                 100.0 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 0.8 
                 1.0 
               
               
                   
                 Muscle Margin (ODO4286) 
                 2.0 
                 1.3 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 11.1 
                 8.4 
               
               
                   
                 Lung Margin (OD03126) 
                 64.2 
                 51.8 
               
               
                   
                 Lung Cancer (OD04404) 
                 6.6 
                 5.1 
               
               
                   
                 Lung Margin (OD04404) 
                 37.4 
                 31.9 
               
               
                   
                 Lung Cancer (OD04565) 
                 1.8 
                 1.3 
               
               
                   
                 Lung Margin (OD04565) 
                 19.3 
                 20.6 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 2.0 
                 2.2 
               
               
                   
                 Lung Margin (OD04237-02) 
                 42.3 
                 37.6 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 0.0 
                 0.2 
               
               
                   
                 Liver Margin (ODO4310) 
                 2.3 
                 0.5 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 1.9 
                 1.8 
               
               
                   
                 Lung Margin (OD04321) 
                 49.0 
                 37.9 
               
               
                   
                 Normal Kidney 
                 5.4 
                 4.8 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 0.4 
                 0.6 
               
               
                   
                 Kidney Margin (OD04338) 
                 3.2 
                 2.1 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 0.7 
                 0.3 
               
               
                   
                 Kidney Margin (OD04339) 
                 1.2 
                 0.2 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 0.4 
                 0.4 
               
               
                   
                 Kidney Margin (OD04340) 
                 5.1 
                 4.2 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.3 
                 0.1 
               
               
                   
                 Kidney Margin (OD04348) 
                 2.4 
                 1.6 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 0.1 
                 0.2 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 0.0 
                 0.1 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 1.9 
                 1.1 
               
               
                   
                 Kidney Cancer 8120607 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin 8120608 
                 0.1 
                 0.0 
               
               
                   
                 Kidney Cancer 8120613 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin 8120614 
                 0.1 
                 0.1 
               
               
                   
                 Kidney Cancer 9010320 
                 1.1 
                 1.0 
               
               
                   
                 Kidney Margin 9010321 
                 0.1 
                 0.2 
               
               
                   
                 Normal Uterus 
                 3.1 
                 2.3 
               
               
                   
                 Uterus Cancer 064011 
                 24.5 
                 18.8 
               
               
                   
                 Normal Thyroid 
                 10.4 
                 9.0 
               
               
                   
                 Thyroid Cancer 064010 
                 0.3 
                 0.0 
               
               
                   
                 Thyroid Cancer A302152 
                 0.5 
                 0.5 
               
               
                   
                 Thyroid Margin A302153 
                 14.5 
                 9.2 
               
               
                   
                 Normal Breast 
                 32.1 
                 31.9 
               
               
                   
                 Breast Cancer (OD04566) 
                 0.5 
                 0.4 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 9.3 
                 4.4 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 9.7 
                 5.9 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 8.2 
                 5.8 
               
               
                   
                 Breast Cancer 064006 
                 8.4 
                 5.3 
               
               
                   
                 Breast Cancer 1024 
                 9.6 
                 9.2 
               
               
                   
                 Breast Cancer 9100266 
                 1.7 
                 2.2 
               
               
                   
                 Breast Margin 9100265 
                 10.7 
                 9.6 
               
               
                   
                 Breast Cancer A209073 
                 11.0 
                 10.2 
               
               
                   
                 Breast Margin A209073 
                 13.6 
                 12.5 
               
               
                   
                 Normal Liver 
                 2.2 
                 1.9 
               
               
                   
                 Liver Cancer 064003 
                 0.6 
                 0.4 
               
               
                   
                 Liver Cancer 1025 
                 0.6 
                 0.2 
               
               
                   
                 Liver Cancer 1026 
                 0.0 
                 0.1 
               
               
                   
                 Liver Cancer 6004-T 
                 0.9 
                 0.3 
               
               
                   
                 Liver Tissue 6004-N 
                 0.2 
                 0.2 
               
               
                   
                 Liver Cancer 6005-T 
                 0.0 
                 0.2 
               
               
                   
                 Liver Tissue 6005-N 
                 0.0 
                 0.0 
               
               
                   
                 Normal Bladder 
                 2.4 
                 0.5 
               
               
                   
                 Bladder Cancer 1023 
                 0.5 
                 0.9 
               
               
                   
                 Bladder Cancer A302173 
                 33.4 
                 31.4 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 0.4 
                 0.0 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 17.4 
                 17.6 
               
               
                   
                 Normal Ovary 
                 22.4 
                 14.9 
               
               
                   
                 Ovarian Cancer 064008 
                 7.1 
                 4.4 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 2.1 
                 1.8 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 1.2 
                 1.8 
               
               
                   
                 Normal Stomach 
                 6.4 
                 4.4 
               
               
                   
                 Gastric Cancer 9060358 
                 3.1 
                 1.4 
               
               
                   
                 Stomach Margin 9060359 
                 1.3 
                 2.3 
               
               
                   
                 Gastric Cancer 9060395 
                 2.4 
                 4.5 
               
               
                   
                 Stomach Margin 9060394 
                 5.3 
                 3.4 
               
               
                   
                 Gastric Cancer 9060397 
                 0.3 
                 0.7 
               
               
                   
                 Stomach Margin 9060396 
                 0.7 
                 0.1 
               
               
                   
                 Gastric Cancer 064005 
                 6.8 
                 4.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1489, Run 152799815    
               
               
                   
                   Column B - Rel. Exp. (%) Ag1489, Run 152799848    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AGG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 0.6 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 1.2 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 1.5 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.9 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.3 
               
               
                   
                 Two Way MLR 3 day 
                 1.7 
               
               
                   
                 Two Way MLR 5 day 
                 0.5 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.5 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.7 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.8 
               
               
                   
                 EOL-1 dbcAMP 
                 34.2 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 18.6 
               
               
                   
                 Dendritic cells none 
                 11.9 
               
               
                   
                 Dendritic cells LPS 
                 0.7 
               
               
                   
                 Dendritic cells anti-CD40 
                 2.7 
               
               
                   
                 Monocytes rest 
                 1.4 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 2.8 
               
               
                   
                 Macrophages LPS 
                 1.1 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.0 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 0.9 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.5 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 1.1 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
               
               
                   
                 Small airway epithelium none 
                 0.6 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.7 
               
               
                   
                 Coronery artery SMC rest 
                 1.9 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 1.6 
               
               
                   
                 Astrocytes rest 
                 0.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 KU-812 (Basophil) rest 
                 48.6 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 26.1 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Liver cirrhosis 
                 6.0 
               
               
                   
                 NCI-H292 none 
                 0.7 
               
               
                   
                 NCI-H292 IL-4 
                 0.0 
               
               
                   
                 NCI-H292 IL-9 
                 0.7 
               
               
                   
                 NCI-H292 IL-13 
                 0.4 
               
               
                   
                 NCI-H292 IFN gamma 
                 1.7 
               
               
                   
                 HPAEC none 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 26.8 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 2.0 
               
               
                   
                 Lung fibroblast IL-4 
                 20.3 
               
               
                   
                 Lung fibroblast IL-9 
                 26.2 
               
               
                   
                 Lung fibroblast IL-13 
                 37.4 
               
               
                   
                 Lung fibroblast IFN gamma 
                 44.1 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 3.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.7 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 2.2 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 12.8 
               
               
                   
                 Dermal fibroblast IL-4 
                 48.3 
               
               
                   
                 Dermal Fibroblasts rest 
                 17.9 
               
               
                   
                 Neutrophils TNFa + LPS 
                 0.0 
               
               
                   
                 Neutrophils rest 
                 0.7 
               
               
                   
                 Colon 
                 10.7 
               
               
                   
                 Lung 
                 100.0 
               
               
                   
                 Thymus 
                 27.9 
               
               
                   
                 Kidney 
                 10.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag4335, Run 184793354    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AGH 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 5D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 97457_Patient-02go_adipose 
                 100.0 
               
               
                   
                 97476_Patient-07sk_skeletal muscle 
                 23.3 
               
               
                   
                 97477_Patient-07ut_uterus 
                 8.7 
               
               
                   
                 97478_Patient-07pl_placenta 
                 7.9 
               
               
                   
                 97481_Patient-08sk_skeletal muscle 
                 54.7 
               
               
                   
                 97482_Patient-08ut_uterus 
                 1.4 
               
               
                   
                 97483_Patient-08pl_placenta 
                 12.1 
               
               
                   
                 97486_Patient-09sk_skeletal muscle 
                 3.3 
               
               
                   
                 97487_Patient-09ut_uterus 
                 28.7 
               
               
                   
                 97488_Patient-09pl_placenta 
                 2.6 
               
               
                   
                 97492_Patient-10ut_uterus 
                 8.4 
               
               
                   
                 97493_Patient-10pl_placenta 
                 9.5 
               
               
                   
                 97495_Patient-11go_adipose 
                 39.5 
               
               
                   
                 97496_Patient-11sk_skeletal muscle 
                 4.4 
               
               
                   
                 97497_Patient-11ut_uterus 
                 11.1 
               
               
                   
                 97498_Patient-11pl_placenta 
                 4.9 
               
               
                   
                 97500_Patient-12go_adipose 
                 24.0 
               
               
                   
                 97501_Patient-12sk_skeletal muscle 
                 6.0 
               
               
                   
                 97502_Patient-12ut_uterus 
                 2.6 
               
               
                   
                 97503_Patient-12pl_placenta 
                 2.9 
               
               
                   
                 94721_Donor 2 U - A_Mesenchymal Stem Cells 
                 2.0 
               
               
                   
                 94722_Donor 2 U - B_Mesenchymal Stem Cells 
                 0.7 
               
               
                   
                 94723_Donor 2 U - C_Mesenchymal Stem Cells 
                 1.7 
               
               
                   
                 94709_Donor 2 AM - A_adipose 
                 2.0 
               
               
                   
                 94710_Donor 2 AM - B_adipose 
                 2.1 
               
               
                   
                 94711_Donor 2 AM - C_adipose 
                 0.3 
               
               
                   
                 94712_Donor 2 AD - A_adipose 
                 2.8 
               
               
                   
                 94713_Donor 2 AD - B_adipose 
                 3.4 
               
               
                   
                 94714_Donor 2 AD - C_adipose 
                 4.5 
               
               
                   
                 94742_Donor 3 U - A_Mesenchymal Stem Cells 
                 0.2 
               
               
                   
                 94743_Donor 3 U - B_Mesenchymal Stem Cells 
                 1.1 
               
               
                   
                 94730_Donor 3 AM - A_adipose 
                 4.2 
               
               
                   
                 94731_Donor 3 AM - B_adipose 
                 2.0 
               
               
                   
                 94732_Donor 3 AM - C_adipose 
                 1.8 
               
               
                   
                 94733_Donor 3 AD - A_adipose 
                 0.5 
               
               
                   
                 94734_Donor 3 AD - B_adipose 
                 0.3 
               
               
                   
                 94735_Donor 3 AD - C_adipose 
                 0.2 
               
               
                   
                 77138_Liver_HepG2untreated 
                 0.5 
               
               
                   
                 73556_Heart_Cardiac stromal cells (primary) 
                 0.0 
               
               
                   
                 81735_Small Intestine 
                 49.3 
               
               
                   
                 72409_Kidney_Proximal Convoluted Tubule 
                 0.6 
               
               
                   
                 82685_Small intestine_Duodenum 
                 5.2 
               
               
                   
                 90650_Adrenal_Adrenocortical adenoma 
                 5.3 
               
               
                   
                 72410_Kidney_HRCE 
                 0.0 
               
               
                   
                 72411_Kidney_HRE 
                 0.8 
               
               
                   
                 73139_Uterus_Uterine smooth muscle cells 
                 4.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag4335, Run 258657707    
               
            
           
         
       
     
      AI_comprehensive panel 13  v1.0 Summary: Ag1489 Expression of this transcript was induced in most rheumatoid arthritis (RA) tissues and in synovium and bone tissues from osteoarthritis (OA) patients. This gene was also highly and consistently expressed in normal lung in 2 out of 3 normal lungs tissues on this panel and in panels 1.4 and 4.1. The expression in diseased lung was reduced or absent. These data show that lung expression of the protein encoded for by this transcript serves an important function that is lost in disease states, but that OA/RA promotes the expression of this gene in the joint. Therapies designed with the protein encoded by this transcript are important for the treatment of OA/RA and lung diseases such as chronic pulmonary obstructive disease, emphysema, allergy and asthma.  
      Ardais Panel 1.1 Summary: Ag1489 Highest expression is detected in normal adjacent lung tissue sample (CT=25). This gene is expressed at higher levels in normal tissue relative to the cancer samples. This expression profile is in agreement with results in panel 2D. This gene codes for a protein containing ig and leucine rich repeat regions and is similar to adlican. Members of this family are integral basement membrane proteins with a variety of functions, including matrix assembly and organization, regulation of cell growth, adhesion and migration. The LRR domain in particular is thought to play an important role in these processes (Hocking A M, Shinomura T, McQuillan D J., 1998, Leucine-rich repeat glycoproteins of the extracellular matrix. Matrix Biol. 17(1):1-19). The expression profile of this gene indicates an important role in lung biology and therefore modulation of this gene, expressed protein and/or use of agonists will be useful in the treatment of lung cancer.  
      General_screening 13  panel_v1.4 Summary: Ag4335 Highest expression of this gene was seen in fetal lung (CT=25.4), with overall expression associated with normal tissues. Expression of this gene was higher in fetal lung relative to adult lung (CT=29) and in fetal skeletal muscle (CT=29) relative to adult skeletal muscle (CT=33). This gene or expressed protein is involved in the development and homeostasis of these organs. Therapeutic modulation of this gene and/or expressed protein is useful in the treatment of lung and skeletal muscle related diseases.  
      This gene was also expressed at significant levels in a variety of metabolic tissues including adipose, adult and fetal liver, adult and fetal heart, pituitary, thyroid and pancreas. Modulation of this gene and/or expressed protein is useful in the treatment of metabolic disorders, including obesity and diabetes.  
      Moderate to low expression of this gene was also seen in all the regions of brain examined including amygdala, hippocampus, substantia nigra, thalamus, cerebellum, cerebral cortex, and spinal cord. Therapeutic modulation of this gene or gene product is useful in the treatment of central nervous system disorders such as Alzheimer&#39;s disease, Parkinson&#39;s disease, epilepsy, multiple sclerosis, schizophrenia and depression.  
      Panel 2D Summary: Ag1489 Highest expression of this gene was detected in normal lung (CTs=27.8). This gene showed higher expression in all the normal adjacent lung, kidney and colon tissues relative to cancer samples. Modulation of this gene, expressed protein and/or use of antibodies or agonists targeting this gene or its protein product are useful in the treatment of these cancers.  
      Panel 4.1D Summary: Ag4335 Highest expression of this gene was detected in normal lung (CT=31). This gene was also expressed in lung fibroblasts, EOL-1 cells and basophils. Expression of the gene was downregulated by TNF-alpha and IL1-beta in lung fibroblasts. Based on the expression profile in this panel as well as that in the A/I panel, therapeutics designed with the encoded protein are useful in the treatment of chronic obstructive pulmonary disease, emphysema, allergy and asthma.  
      Panel 5D Summary: Ag4335 Highest expression of this gene was detected in adipose tissue from a diabetic patient (CT=30.8). Significant expression of this gene was also seen in skeletal muscle, adipose, uterus, placenta and small intestine. Modulation of this gene or its expressed protein is useful in the treatment of metabolic diseases such as obesity and diabetes.  
      AH. CG5578401 and CG5578403: Nephrin-like  
      Expression of gene CG55784-03 and variant CG55784-01 was assessed using the primer-probe sets Ag2844 and Ag6457, described in Tables AHA and AHB. Results of the RTQ-PCR runs are shown in Tables AHC, AHD and AHE. Please note that the probe and primer set Ag6457 is specific to the CG55784-03 only.  
               TABLE AHA                          Probe Name Ag2844                                                 Start   SEQ ID           Primers   Sequences   Length   Position   No               Forward   5′-ctttccactgctctgcaaag-3′   20   1053   1423                   Probe   TET-5′-aacccagctgtcacccagtacaggtg-3′-   26   1076   1424           TAMRA               Reverse   5′-gtcctgtacacctctccagatg-3′   22   1131   1425                  
 
     
       
         
           
               
             
               
                 TABLE AHB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag6457 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-cgacttccagaccatctacaact-3′ 
                 23 
                 1723 
                 1426 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-cttcggctccgacactgagatcatc-3′- 
                 25 
                 1762 
                 1427 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-ggcacagactcttgctcctt-3′ 
                 20 
                 1793 
                 1428 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AHC 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.6 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 0.0 
               
               
                   
                 Melanoma* Hs688(A).T 
                 13.6 
               
               
                   
                 Melanoma* Hs688(B).T 
                 15.9 
               
               
                   
                 Melanoma* M14 
                 0.2 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.0 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.3 
               
               
                   
                 Testis Pool 
                 0.0 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate Pool 
                 0.8 
               
               
                   
                 Placenta 
                 0.4 
               
               
                   
                 Uterus Pool 
                 0.4 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 1.7 
               
               
                   
                 Ovarian ca. IGROV-1 
                 1.7 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 1.8 
               
               
                   
                 Ovary 
                 0.7 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca. BT 549 
                 0.0 
               
               
                   
                 Breast ca. T47D 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Breast Pool 
                 0.0 
               
               
                   
                 Trachea 
                 2.0 
               
               
                   
                 Lung 
                 0.4 
               
               
                   
                 Fetal Lung 
                 5.4 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 3.7 
               
               
                   
                 Lung ca. SHP-77 
                 0.0 
               
               
                   
                 Lung ca. A549 
                 9.0 
               
               
                   
                 Lung ca. NCI-H526 
                 1.1 
               
               
                   
                 Lung ca. NCI-H23 
                 0.0 
               
               
                   
                 Lung ca. NCI-H460 
                 0.1 
               
               
                   
                 Lung ca. HOP-62 
                 0.5 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 0.0 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
               
               
                   
                 Kidney Pool 
                 0.0 
               
               
                   
                 Fetal Kidney 
                 0.1 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 3.2 
               
               
                   
                 Renal ca. ACHN 
                 35.8 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Bladder 
                 0.4 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.0 
               
               
                   
                 Gastric ca. KATO III 
                 2.4 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon cancer tissue 
                 0.0 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 0.4 
               
               
                   
                 Small Intestine Pool 
                 1.4 
               
               
                   
                 Stomach Pool 
                 0.0 
               
               
                   
                 Bone Marrow Pool 
                 0.3 
               
               
                   
                 Fetal Heart 
                 1.5 
               
               
                   
                 Heart Pool 
                 0.5 
               
               
                   
                 Lymph Node Pool 
                 1.0 
               
               
                   
                 Fetal Skeletal Muscle 
                 0.0 
               
               
                   
                 Skeletal Muscle Pool 
                 0.0 
               
               
                   
                 Spleen Pool 
                 1.1 
               
               
                   
                 Thymus Pool 
                 0.4 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 8.0 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 2.9 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 0.8 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 4.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.7 
               
               
                   
                 Brain (Amygdala) Pool 
                 32.3 
               
               
                   
                 Brain (cerebellum) 
                 100.0 
               
               
                   
                 Brain (fetal) 
                 41.2 
               
               
                   
                 Brain (Hippocampus) Pool 
                 29.3 
               
               
                   
                 Cerebral Cortex Pool 
                 35.8 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 25.5 
               
               
                   
                 Brain (Thalamus) Pool 
                 56.3 
               
               
                   
                 Brain (whole) 
                 79.0 
               
               
                   
                 Spinal Cord Pool 
                 16.8 
               
               
                   
                 Adrenal Gland 
                 2.0 
               
               
                   
                 Pituitary gland Pool 
                 0.0 
               
               
                   
                 Salivary Gland 
                 1.6 
               
               
                   
                 Thyroid (female) 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.0 
               
               
                   
                 Pancreas Pool 
                 0.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag6457, Run 277250272    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AHD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 74.7 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.3 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.0 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 2.4 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.0 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
               
               
                   
                 Small airway epithelium none 
                 0.0 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Coronery artery SMC rest 
                 4.4 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 14.1 
               
               
                   
                 Astrocytes rest 
                 2.9 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 5.2 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Liver cirrhosis 
                 0.0 
               
               
                   
                 NCI-H292 none 
                 10.2 
               
               
                   
                 NCI-H292 IL-4 
                 10.2 
               
               
                   
                 NCI-H292 IL-9 
                 0.0 
               
               
                   
                 NCI-H292 IL-13 
                 14.3 
               
               
                   
                 NCI-H292 IFN gamma 
                 0.0 
               
               
                   
                 HPAEC none 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 11.5 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 6.6 
               
               
                   
                 Lung fibroblast IL-4 
                 20.9 
               
               
                   
                 Lung fibroblast IL-9 
                 5.1 
               
               
                   
                 Lung fibroblast IL-13 
                 5.3 
               
               
                   
                 Lung fibroblast IFN gamma 
                 23.2 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 100.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 59.5 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 59.0 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 2.9 
               
               
                   
                 Dermal fibroblast IL-4 
                 9.3 
               
               
                   
                 Dermal Fibroblasts rest 
                 7.5 
               
               
                   
                 Neutrophils TNFa + LPS 
                 0.0 
               
               
                   
                 Neutrophils rest 
                 0.0 
               
               
                   
                 Colon 
                 2.8 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Thymus 
                 0.0 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp.(%) Ag6457, Run 269261799    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AHE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 43.5 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.0 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.0 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
               
               
                   
                 Small airway epithelium none 
                 0.0 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Coronery artery SMC rest 
                 1.7 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 5.1 
               
               
                   
                 Astrocytes rest 
                 2.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 3.7 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Liver cirrhosis 
                 0.3 
               
               
                   
                 Lupus kidney 
                 0.0 
               
               
                   
                 NCI-H292 none 
                 1.8 
               
               
                   
                 NCI-H292 IL-4 
                 27.2 
               
               
                   
                 NCI-H292 IL-9 
                 3.7 
               
               
                   
                 NCI-H292 IL-13 
                 17.8 
               
               
                   
                 NCI-H292 IFN gamma 
                 0.0 
               
               
                   
                 HPAEC none 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 4.3 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 3.4 
               
               
                   
                 Lung fibroblast IL-4 
                 12.5 
               
               
                   
                 Lung fibroblast IL-9 
                 2.6 
               
               
                   
                 Lung fibroblast IL-13 
                 5.3 
               
               
                   
                 Lung fibroblast IFN gamma 
                 5.2 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 90.1 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 100.0 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 39.8 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 1.6 
               
               
                   
                 Dermal fibroblast IL-4 
                 4.5 
               
               
                   
                 IBD Colitis 2 
                 0.0 
               
               
                   
                 IBD Crohn&#39;s 
                 0.2 
               
               
                   
                 Colon 
                 1.3 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Thymus 
                 0.4 
               
               
                   
                 Kidney 
                 0.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp.(%) Ag2844, Run 164299480    
               
            
           
         
       
     
      General_screening 13  panel_v1.6 Summary: Ag6457 This probe/primer set was specific for the CG55784-03 gene variant. Expression of this gene was highest in cerebellum (CT=29.5). Highly brain-preferential expression of the CG55784-03 gene demonstrates a specific role for this gene product in the brain. This gene encodes a protein that is homologous to a neural cell adhesion molecule (NCAM). NCAM related proteins, such as Nr-CAM, play a critical role in neurite extension (Sakurai et al., J Cell Biol 2001 154:1259-73). Eintroduction of ligands specific for this gene product, such as contactin, in directed brain regions have utility in fostering focal neurite outgrowth and in therapeutically countering neurite degeneration of neurodegenerative diseases such as Alzheimer&#39;s, ataxias, and Parkinson&#39;s disease.  
      In addition, the expression of this gene was relatively high in the normal brain samples compared to the cancer cell lines derived from brain cancer. Expression of this gene is useful as a marker to differentiate between normal and cancerous tissue. There were also significantly higher levels of expression in renal cancer cell lines compared to a normal kidney sample. Expression of this gene is also useful as a marker in renal cancer.  
      Panel 4.1D Summary: Ag6457 This probe/primer set is specific for the CG55784-03 gene variant. Expression of this gene was highest in dermal fibroblasts (CT=31.8) and was relatively treatment independent. This gene was also expressed in CD45RA (naive) T cells. Therapeutic modulation of this gene or its protein product is useful in the treatment of psoriasis or diseases mediated by activated T cells.  
      Panel 4D Summary: Ag2844 This transcript was induced in IL-4 and IL-13 treated NCI-H292 cells, expressed constitutively in a dermal fibroblast cell line and was slightly induced by IL-4 in lung fibroblasts. CD45RA (naive) T cells also expressed the transcript. The transcript encodes a NCAM-like molecule. Based on the expression pattern of the transcript, the homology to NCAM protein, and the regulation of transcript expression by IL-4 and IL-13, therapeutics designed with the protein encoded for by this transcript are important in the treatment of asthma and COPD.  
      AI. CG55790-01 and CG55790-02: B7-H2B  
      Expression of gene CG55790-02 and variant CG55790-01 was assessed using the primer-probe sets Ag1845, Ag2589, Ag2621, Ag2915, and Ag8156, described in Tables AIA, AIB, AIC, AID, and AIE. Results of the RTQ-PCR runs are shown in Tables AIF, AIG, AIH, AII, All and AIKPlease note that only the probe and primer sets Ag2589, Ag2621, and Ag2915 correspond to the CG55790-01 variant.  
               TABLE AIA                          Probe Name Ag1845                                                 Start   SEQ ID           Primers   Sequences   Length   Position   No               Forward   5′-catcacgtgtgagctcacagt-3′   21   7434   1429                   Probe   TET-5′-cttccacatggtgcactgctgct-3′-TAMRA   23   7393   1430               Reverse   5′-agaatttgcagacacagcaatt-3′   22   7366   1431                  
 
     
       
         
           
               
             
               
                 TABLE AIB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag2589 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-gagctcaccttcacgtgtacat-3′ 
                 22 
                 460 
                 1432 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ctaccccaggcccaacgtgtactg-3′- 
                 24 
                 492 
                 1433 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-gctgttgtccgtcttattgatc-3′ 
                 22 
                 516 
                 1434 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AIC 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag2621 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-gagctcaccttcacgtgtacat-3′ 
                 22 
                 460 
                 1435 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ctaccccaggcccaacgtgtactg-3′- 
                 24 
                 492 
                 1436 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-gctgttgtccgtcttattgatc-3′ 
                 22 
                 516 
                 1437 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AID 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag2915 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-gagctcaccttcacgtgtacat-3′ 
                 22 
                 460 
                 1438 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ctaccccaggcccaacgtgtactg-3′- 
                 24 
                 492 
                 1439 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-gctgttgtccgtcttattgatc-3′ 
                 22 
                 516 
                 1440 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AIE 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag8156 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-tgccagctgtctttcagagt-3′ 
                 20 
                 955 
                 1441 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ctttcaaaaggcaaaagtcccttgcc-3′- 
                 26 
                 984 
                 1439 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-gcgtctccaggaacaacagt-3′ 
                 20 
                 1017 
                 1443 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AIF 
               
             
            
               
                   
               
               
                   
               
               
                 AI_comprehensive panel_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 110967 COPD-F 
                 8.5 
               
               
                   
                 110980 COPD-F 
                 4.8 
               
               
                   
                 110968 COPD-M 
                 6.7 
               
               
                   
                 110977 COPD-M 
                 8.5 
               
               
                   
                 110989 Emphysema-F 
                 12.9 
               
               
                   
                 110992 Emphysema-F 
                 7.5 
               
               
                   
                 110993 Emphysema-F 
                 8.5 
               
               
                   
                 110994 Emphysema-F 
                 3.0 
               
               
                   
                 110995 Emphysema-F 
                 14.9 
               
               
                   
                 110996 Emphysema-F 
                 1.6 
               
               
                   
                 110997 Asthma-M 
                 14.1 
               
               
                   
                 111001 Asthma-F 
                 7.9 
               
               
                   
                 111002 Asthma-F 
                 12.6 
               
               
                   
                 111003 Atopic Asthma-F 
                 13.4 
               
               
                   
                 111004 Atopic Asthma-F 
                 16.5 
               
               
                   
                 111005 Atopic Asthma-F 
                 7.7 
               
               
                   
                 111006 Atopic Asthma-F 
                 0.9 
               
               
                   
                 111417 Allergy-M 
                 6.3 
               
               
                   
                 112347 Allergy-M 
                 1.7 
               
               
                   
                 112349 Normal Lung-F 
                 0.5 
               
               
                   
                 112357 Normal Lung-F 
                 1.7 
               
               
                   
                 112354 Normal Lung-M 
                 2.9 
               
               
                   
                 112374 Crohns-F 
                 3.3 
               
               
                   
                 112389 Match Control Crohns-F 
                 17.9 
               
               
                   
                 112375 Crohns-F 
                 1.8 
               
               
                   
                 112732 Match Control Crohns-F 
                 39.5 
               
               
                   
                 112725 Crohns-M 
                 1.7 
               
               
                   
                 112387 Match Control Crohns-M 
                 4.6 
               
               
                   
                 112378 Crohns-M 
                 0.7 
               
               
                   
                 112390 Match Control Crohns-M 
                 12.1 
               
               
                   
                 112726 Crohns-M 
                 10.1 
               
               
                   
                 112731 Match Control Crohns-M 
                 18.9 
               
               
                   
                 112380 Ulcer Col-F 
                 9.6 
               
               
                   
                 112734 Match Control Ulcer Col-F 
                 100.0 
               
               
                   
                 112384 Ulcer Col-F 
                 17.1 
               
               
                   
                 112737 Match Control Ulcer Col-F 
                 13.5 
               
               
                   
                 112386 Ulcer Col-F 
                 1.8 
               
               
                   
                 112738 Match Control Ulcer Col-F 
                 1.4 
               
               
                   
                 112381 Ulcer Col-M 
                 7.3 
               
               
                   
                 112735 Match Control Ulcer Col-M 
                 7.2 
               
               
                   
                 112382 Ulcer Col-M 
                 12.5 
               
               
                   
                 112394 Match Control Ulcer Col-M 
                 2.3 
               
               
                   
                 112383 Ulcer Col-M 
                 6.3 
               
               
                   
                 112736 Match Control Ulcer Col-M 
                 13.0 
               
               
                   
                 112423 Psoriasis-F 
                 7.1 
               
               
                   
                 112427 Match Control Psoriasis-F 
                 14.5 
               
               
                   
                 112418 Psoriasis-M 
                 6.6 
               
               
                   
                 112723 Match Control Psoriasis-M 
                 1.0 
               
               
                   
                 112419 Psoriasis-M 
                 9.9 
               
               
                   
                 112424 Match Control Psoriasis-M 
                 10.7 
               
               
                   
                 112420 Psoriasis-M 
                 21.5 
               
               
                   
                 112425 Match Control Psoriasis-M 
                 13.8 
               
               
                   
                 104689 (MF) OA Bone-Backus 
                 17.1 
               
               
                   
                 104690 (MF) Adj “Normal” Bone-Backus 
                 6.8 
               
               
                   
                 104691 (MF) OA Synovium-Backus 
                 14.6 
               
               
                   
                 104692 (BA) OA Cartilage-Backus 
                 0.4 
               
               
                   
                 104694 (BA) OA Bone-Backus 
                 13.3 
               
               
                   
                 104695 (BA) Adj “Normal” Bone-Backus 
                 9.3 
               
               
                   
                 104696 (BA) OA Synovium-Backus 
                 7.9 
               
               
                   
                 104700 (SS) OA Bone-Backus 
                 7.5 
               
               
                   
                 104701 (SS) Adj “Normal” Bone-Backus 
                 7.7 
               
               
                   
                 104702 (SS) OA Synovium-Backus 
                 24.5 
               
               
                   
                 117093 OA Cartilage Rep7 
                 7.7 
               
               
                   
                 112672 OA Bone5 
                 6.2 
               
               
                   
                 112673 OA Synovium5 
                 1.1 
               
               
                   
                 112674 OA Synovial Fluid cells5 
                 2.6 
               
               
                   
                 117100 OA Cartilage Rep14 
                 4.3 
               
               
                   
                 112756 OA Bone9 
                 14.6 
               
               
                   
                 112757 OA Synovium9 
                 7.1 
               
               
                   
                 112758 OA Synovial Fluid Cells9 
                 4.2 
               
               
                   
                 117125 RA Cartilage Rep2 
                 4.7 
               
               
                   
                 113492 Bone2 RA 
                 4.8 
               
               
                   
                 113493 Synovium2 RA 
                 3.6 
               
               
                   
                 113494 Syn Fluid Cells RA 
                 7.5 
               
               
                   
                 113499 Cartilage4 RA 
                 9.6 
               
               
                   
                 113500 Bone4 RA 
                 10.7 
               
               
                   
                 113501 Synovium4 RA 
                 6.9 
               
               
                   
                 113502 Syn Fluid Cells4 RA 
                 5.4 
               
               
                   
                 113495 Cartilage3 RA 
                 4.0 
               
               
                   
                 113496 Bone3 RA 
                 7.2 
               
               
                   
                 113497 Synovium3 RA 
                 4.4 
               
               
                   
                 113498 Syn Fluid Cells3 RA 
                 6.2 
               
               
                   
                 117106 Normal Cartilage Rep20 
                 7.3 
               
               
                   
                 113663 Bone3 Normal 
                 0.2 
               
               
                   
                 113664 Synovium3 Normal 
                 0.0 
               
               
                   
                 113665 Syn Fluid Cells3 Normal 
                 0.4 
               
               
                   
                 117107 Normal Cartilage Rep22 
                 3.0 
               
               
                   
                 113667 Bone4 Normal 
                 4.3 
               
               
                   
                 113668 Synovium4 Normal 
                 2.7 
               
               
                   
                 113669 Syn Fluid Cells4 Normal 
                 7.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp.(%) Ag1845, Run 217699370    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AIG 
               
             
            
               
                   
               
               
                   
               
               
                 CNS_neurodegeneration_v1.0 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
                 D 
                 E 
                 F 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 AD 1 Hippo 
                 37.6 
                 19.1 
                 26.4 
                 26.1 
                 42.3 
                 37.9 
               
               
                 AD 2 Hippo 
                 26.4 
                 11.1 
                 26.6 
                 21.2 
                 27.0 
                 33.4 
               
               
                 AD 3 Hippo 
                 39.5 
                 15.6 
                 24.1 
                 15.1 
                 20.4 
                 32.3 
               
               
                 AD 4 Hippo 
                 24.3 
                 10.6 
                 16.8 
                 10.7 
                 20.9 
                 28.5 
               
               
                 AD 5 Hippo 
                 29.5 
                 23.8 
                 26.2 
                 22.7 
                 32.3 
                 28.3 
               
               
                 AD 6 Hippo 
                 62.0 
                 45.4 
                 57.4 
                 45.1 
                 56.3 
                 75.8 
               
               
                 Control 2 Hippo 
                 57.4 
                 22.4 
                 45.7 
                 29.1 
                 41.5 
                 50.7 
               
               
                 Control 4 Hippo 
                 22.8 
                 10.9 
                 27.4 
                 20.4 
                 24.5 
                 25.3 
               
               
                 Control (Path) 3 Hippo 
                 22.7 
                 100.0 
                 14.6 
                 12.3 
                 14.7 
                 12.5 
               
               
                 AD 1 Temporal Ctx 
                 48.0 
                 27.2 
                 33.9 
                 27.9 
                 33.7 
                 44.8 
               
               
                 AD 2 Temporal Ctx 
                 39.0 
                 30.1 
                 25.2 
                 21.5 
                 33.7 
                 29.9 
               
               
                 AD 3 Temporal Ctx 
                 42.3 
                 19.8 
                 19.5 
                 14.8 
                 13.4 
                 16.3 
               
               
                 AD 4 Temporal Ctx 
                 35.1 
                 14.7 
                 24.3 
                 22.7 
                 33.7 
                 26.2 
               
               
                 AD 5 Inf Temporal Ctx 
                 70.2 
                 28.3 
                 50.3 
                 45.4 
                 63.7 
                 60.3 
               
               
                 AD 5 Sup Temporal Ctx 
                 48.6 
                 17.8 
                 37.4 
                 32.1 
                 45.1 
                 35.1 
               
               
                 AD 6 Inf Temporal Ctx 
                 100.0 
                 19.6 
                 100.0 
                 100.0 
                 100.0 
                 100.0 
               
               
                 AD 6 Sup Temporal Ctx 
                 57.4 
                 27.0 
                 47.3 
                 33.4 
                 49.0 
                 59.9 
               
               
                 Control 1 Temporal Ctx 
                 11.8 
                 9.7 
                 14.8 
                 8.8 
                 14.2 
                 14.0 
               
               
                 Control 2 Temporal Ctx 
                 33.7 
                 23.0 
                 30.8 
                 26.8 
                 11.3 
                 45.4 
               
               
                 Control 3 Temporal Ctx 
                 20.6 
                 15.9 
                 18.6 
                 13.7 
                 17.2 
                 18.8 
               
               
                 Control 3 Temporal Ctx 
                 21.9 
                 4.5 
                 14.9 
                 12.5 
                 26.6 
                 23.7 
               
               
                 Control (Path) 1 
                 27.2 
                 26.1 
                 27.5 
                 19.6 
                 28.5 
                 31.4 
               
               
                 Temporal Ctx 
               
               
                 Control (Path) 2 
                 16.7 
                 7.2 
                 18.3 
                 16.5 
                 17.7 
                 23.2 
               
               
                 Temporal Ctx 
               
               
                 Control (Path) 3 
                 23.2 
                 12.4 
                 7.9 
                 6.0 
                 7.2 
                 10.8 
               
               
                 Temporal Ctx 
               
               
                 Control (Path) 4 
                 17.4 
                 35.4 
                 15.1 
                 12.9 
                 17.3 
                 19.6 
               
               
                 Temporal Ctx 
               
               
                 AD 1 Occipital Ctx 
                 30.4 
                 9.2 
                 22.2 
                 14.5 
                 25.0 
                 23.3 
               
               
                 AD 2 Occipital Ctx 
                 1.3 
                 26.1 
                 1.9 
                 14.8 
                 2.5 
                 1.5 
               
               
                 (Missing) 
               
               
                 AD 3 Occipital Ctx 
                 26.8 
                 16.0 
                 17.3 
                 14.6 
                 23.0 
                 20.9 
               
               
                 AD 4 Occipital Ctx 
                 45.1 
                 13.0 
                 27.9 
                 22.5 
                 27.2 
                 0.1 
               
               
                 AD 5 Occipital Ctx 
                 33.0 
                 57.8 
                 27.5 
                 31.2 
                 27.9 
                 32.1 
               
               
                 AD 6 Occipital Ctx 
                 47.3 
                 22.7 
                 36.6 
                 19.3 
                 40.6 
                 44.1 
               
               
                 Control 1 Occipital Ctx 
                 27.5 
                 16.2 
                 16.4 
                 11.3 
                 12.8 
                 16.5 
               
               
                 Control 2 Occipital Ctx 
                 39.8 
                 15.1 
                 28.3 
                 29.3 
                 42.0 
                 42.3 
               
               
                 Control 3 Occipital Ctx 
                 20.7 
                 16.0 
                 18.7 
                 13.0 
                 18.6 
                 16.4 
               
               
                 Control 4 Occipital Ctx 
                 35.1 
                 23.5 
                 17.6 
                 19.6 
                 24.3 
                 22.5 
               
               
                 Control (Path) 1 
                 47.0 
                 23.3 
                 44.4 
                 35.8 
                 47.0 
                 51.8 
               
               
                 Occipital Ctx 
               
               
                 Control (Path) 2 
                 18.3 
                 32.5 
                 21.9 
                 17.6 
                 31.4 
                 23.8 
               
               
                 Occipital Ctx 
               
               
                 Control (Path) 3 
                 23.8 
                 8.2 
                 12.6 
                 15.2 
                 12.2 
                 22.5 
               
               
                 Occipital Ctx 
               
               
                 Control (Path) 4 
                 22.8 
                 14.6 
                 20.9 
                 17.8 
                 21.0 
                 23.2 
               
               
                 Occipital Ctx 
               
               
                 Control 1 Parietal Ctx 
                 34.6 
                 13.6 
                 25.0 
                 20.7 
                 22.5 
                 28.3 
               
               
                 Control 2 Parietal Ctx 
                 48.0 
                 18.0 
                 36.9 
                 25.3 
                 35.4 
                 40.1 
               
               
                 Control 3 Parietal Ctx 
                 37.6 
                 30.6 
                 26.4 
                 20.3 
                 31.4 
                 24.1 
               
               
                 Control (Path) 1 
                 29.5 
                 11.9 
                 28.7 
                 23.3 
                 28.7 
                 31.9 
               
               
                 Parietal Ctx 
               
               
                 Control (Path) 2 
                 24.5 
                 21.8 
                 19.8 
                 17.3 
                 29.9 
                 28.3 
               
               
                 Parietal Ctx 
               
               
                 Control (Path) 3 
                 15.6 
                 17.6 
                 13.2 
                 9.0 
                 8.4 
                 16.8 
               
               
                 Parietal Ctx 
               
               
                 Control (Path) 4 
                 23.8 
                 11.7 
                 22.7 
                 21.0 
                 23.0 
                 22.5 
               
               
                 Parietal Ctx 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag1845, Run 207807655    
               
               
                   Column B - Rel. Exp. (%) Ag1845, Run 224079124    
               
               
                   Column C - Rel. Exp. (%) Ag2589, Run 208776915    
               
               
                   Column D - Rel. Exp. (%) Ag2621, Run 208393684    
               
               
                   Column E - Rel. Exp. (%) Ag2915, Run 209735956    
               
               
                   Column F - Rel. Exp. (%) Ag2915, Run 266906552    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AIH 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
                 D 
                 E 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Liver adenocarcinoma 
                 3.9 
                 4.7 
                 23.8 
                 17.6 
                 22.8 
               
               
                 Pancreas 
                 0.9 
                 0.3 
                 0.8 
                 1.6 
                 2.3 
               
               
                 Pancreatic ca. CAPAN 2 
                 0.0 
                 0.0 
                 2.6 
                 0.5 
                 1.0 
               
               
                 Adrenal gland 
                 1.6 
                 2.1 
                 3.7 
                 3.2 
                 1.9 
               
               
                 Thyroid 
                 2.2 
                 2.9 
                 4.2 
                 5.3 
                 3.3 
               
               
                 Salivary gland 
                 2.0 
                 3.1 
                 6.3 
                 4.0 
                 4.2 
               
               
                 Pituitary gland 
                 0.9 
                 1.1 
                 2.0 
                 2.0 
                 1.4 
               
               
                 Brain (fetal) 
                 0.2 
                 0.9 
                 4.6 
                 6.0 
                 3.3 
               
               
                 Brain (whole) 
                 31.2 
                 31.4 
                 90.8 
                 90.8 
                 77.4 
               
               
                 Brain (amygdala) 
                 28.5 
                 24.7 
                 34.9 
                 31.4 
                 34.4 
               
               
                 Brain (cerebellum) 
                 3.0 
                 1.5 
                 21.6 
                 18.6 
                 20.7 
               
               
                 Brain (hippocampus) 
                 100.0 
                 100.0 
                 39.2 
                 29.9 
                 27.7 
               
               
                 Brain (substantia nigra) 
                 26.1 
                 21.3 
                 86.5 
                 60.7 
                 67.8 
               
               
                 Brain (thalamus) 
                 29.9 
                 31.0 
                 89.5 
                 49.7 
                 59.0 
               
               
                 Cerebral Cortex 
                 20.0 
                 16.4 
                 46.3 
                 33.2 
                 38.4 
               
               
                 Spinal cord 
                 15.0 
                 12.7 
                 29.9 
                 20.2 
                 31.0 
               
               
                 glio/astro U87-MG 
                 2.6 
                 3.5 
                 18.7 
                 13.3 
                 18.9 
               
               
                 glio/astro U-118-MG 
                 1.3 
                 0.3 
                 0.6 
                 1.6 
                 1.6 
               
               
                 astrocytoma SW 1783 
                 0.0 
                 0.1 
                 1.5 
                 1.0 
                 0.3 
               
               
                 neuro*; met SK-N-AS 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 astrocytoma SF-539 
                 5.5 
                 4.2 
                 28.9 
                 15.3 
                 21.8 
               
               
                 astrocytoma SNB-75 
                 1.9 
                 1.3 
                 10.7 
                 5.4 
                 5.5 
               
               
                 glioma SNB-19 
                 0.6 
                 1.6 
                 2.4 
                 1.7 
                 3.6 
               
               
                 glioma U251 
                 0.4 
                 0.9 
                 10.0 
                 7.1 
                 5.0 
               
               
                 glioma SF-295 
                 11.3 
                 12.1 
                 24.1 
                 17.1 
                 25.5 
               
               
                 Heart (fetal) 
                 12.9 
                 8.2 
                 29.3 
                 24.5 
                 31.4 
               
               
                 Heart 
                 1.9 
                 2.0 
                 12.8 
                 8.5 
                 12.2 
               
               
                 Skeletal muscle (fetal) 
                 54.7 
                 48.6 
                 30.6 
                 34.9 
                 36.1 
               
               
                 Skeletal muscle 
                 1.0 
                 0.6 
                 3.1 
                 4.4 
                 3.2 
               
               
                 Bone marrow 
                 3.2 
                 2.6 
                 3.3 
                 3.5 
                 3.6 
               
               
                 Thymus 
                 4.9 
                 5.3 
                 10.2 
                 11.1 
                 11.3 
               
               
                 Spleen 
                 15.9 
                 15.8 
                 11.2 
                 10.7 
                 15.3 
               
               
                 Lymph node 
                 11.4 
                 11.0 
                 27.0 
                 29.5 
                 28.7 
               
               
                 Colorectal 
                 4.5 
                 6.5 
                 9.5 
                 8.1 
                 7.5 
               
               
                 Stomach 
                 9.2 
                 8.5 
                 9.5 
                 8.2 
                 9.7 
               
               
                 Small intestine 
                 5.7 
                 6.4 
                 6.8 
                 4.6 
                 5.7 
               
               
                 Colon ca. SW480 
                 2.0 
                 4.7 
                 7.3 
                 6.3 
                 7.9 
               
               
                 Colon ca.* SW620(SW480 met) 
                 0.8 
                 2.1 
                 12.2 
                 26.4 
                 19.2 
               
               
                 Colon ca. HT29 
                 0.3 
                 0.4 
                 5.2 
                 4.2 
                 4.3 
               
               
                 Colon ca. HCT-116 
                 4.9 
                 6.5 
                 12.2 
                 14.7 
                 14.2 
               
               
                 Colon ca. CaCo-2 
                 15.1 
                 12.4 
                 30.8 
                 28.5 
                 29.7 
               
               
                 Colon ca. tissue(ODO3866) 
                 5.9 
                 5.6 
                 17.3 
                 24.3 
                 19.3 
               
               
                 Colon ca. HCC-2998 
                 5.0 
                 9.9 
                 30.8 
                 31.9 
                 35.8 
               
               
                 Gastric ca.* (liver met) NCI-N87 
                 3.3 
                 6.0 
                 6.1 
                 7.4 
                 6.2 
               
               
                 Bladder 
                 2.1 
                 1.9 
                 14.3 
                 9.7 
                 15.7 
               
               
                 Trachea 
                 9.7 
                 5.7 
                 3.0 
                 2.3 
                 2.3 
               
               
                 Kidney 
                 5.5 
                 3.9 
                 24.0 
                 23.2 
                 21.9 
               
               
                 Kidney (fetal) 
                 11.8 
                 14.4 
                 100.0 
                 100.0 
                 85.9 
               
               
                 Renal ca. 786-0 
                 6.5 
                 5.2 
                 27.4 
                 28.3 
                 33.2 
               
               
                 Renal ca. A498 
                 8.2 
                 9.6 
                 19.3 
                 21.5 
                 21.8 
               
               
                 Renal ca. RXF 393 
                 3.5 
                 3.6 
                 50.0 
                 55.9 
                 48.6 
               
               
                 Renal ca. ACHN 
                 3.2 
                 4.7 
                 8.7 
                 7.6 
                 9.2 
               
               
                 Renal ca. UO-31 
                 3.0 
                 50.0 
                 3.3 
                 4.2 
                 4.2 
               
               
                 Renal ca. TK-10 
                 4.4 
                 4.9 
                 18.0 
                 13.7 
                 15.5 
               
               
                 Liver 
                 3.2 
                 1.2 
                 5.6 
                 4.4 
                 8.0 
               
               
                 Liver (fetal) 
                 2.7 
                 2.5 
                 1.9 
                 5.6 
                 2.6 
               
               
                 Liver ca. (hepatoblast) HepG2 
                 1.9 
                 3.0 
                 10.8 
                 8.7 
                 9.6 
               
               
                 Lung 
                 7.5 
                 7.7 
                 12.8 
                 13.9 
                 17.0 
               
               
                 Lung (fetal) 
                 7.0 
                 8.2 
                 13.3 
                 6.8 
                 5.0 
               
               
                 Lung ca. (small cell) LX-1 
                 2.6 
                 2.3 
                 9.0 
                 6.1 
                 9.6 
               
               
                 Lung ca. (small cell) NCI-H69 
                 0.7 
                 0.3 
                 1.5 
                 1.0 
                 0.5 
               
               
                 Lung ca. (s. cell var.) SHP-77 
                 0.2 
                 0.0 
                 0.0 
                 0.0 
                 0.5 
               
               
                 Lung ca. (large cell)NCI-H460 
                 0.5 
                 1.1 
                 0.6 
                 0.0 
                 0.7 
               
               
                 Lung ca. (non-sm. cell) A549 
                 0.3 
                 0.2 
                 4.0 
                 4.0 
                 5.7 
               
               
                 Lung ca. (non-s. cell) NCI-H23 
                 4.0 
                 3.3 
                 8.4 
                 6.6 
                 7.8 
               
               
                 Lung ca. (non-s. cell) HOP-62 
                 1.5 
                 1.7 
                 1.5 
                 2.4 
                 3.3 
               
               
                 Lung ca. (non-s. cl) NCI-H522 
                 4.0 
                 8.4 
                 13.4 
                 12.3 
                 12.0 
               
               
                 Lung ca. (squam.) SW 900 
                 2.0 
                 0.4 
                 5.9 
                 5.8 
                 4.6 
               
               
                 Lung ca. (squam.) NCI-H596 
                 0.0 
                 0.0 
                 0.0 
                 0.4 
                 1.1 
               
               
                 Mammary gland 
                 12.3 
                 7.6 
                 32.1 
                 26.2 
                 32.1 
               
               
                 Breast ca.* (pl. ef) MCF-7 
                 15.3 
                 10.5 
                 76.3 
                 79.0 
                 100.0 
               
               
                 Breast ca.* (pl. ef) MDA-MB-231 
                 1.8 
                 2.0 
                 6.2 
                 6.7 
                 6.5 
               
               
                 Breast ca.* (pl. ef) T47D 
                 4.5 
                 6.4 
                 35.8 
                 31.9 
                 37.4 
               
               
                 Breast ca. BT-549 
                 0.9 
                 1.4 
                 9.1 
                 6.3 
                 6.2 
               
               
                 Breast ca. MDA-N 
                 0.6 
                 0.9 
                 2.9 
                 4.3 
                 6.5 
               
               
                 Ovary 
                 2.2 
                 4.0 
                 5.0 
                 6.3 
                 6.3 
               
               
                 Ovarian ca. OVCAR-3 
                 8.7 
                 6.9 
                 26.2 
                 31.6 
                 41.2 
               
               
                 Ovarian ca. OVCAR-4 
                 1.6 
                 1.9 
                 23.8 
                 11.5 
                 20.2 
               
               
                 Ovarian ca. OVCAR-5 
                 1.9 
                 2.6 
                 20.7 
                 17.6 
                 14.7 
               
               
                 Ovarian ca. OVCAR-8 
                 0.9 
                 1.8 
                 2.5 
                 2.7 
                 1.3 
               
               
                 Ovarian ca. IGROV-1 
                 1.9 
                 1.0 
                 10.7 
                 8.1 
                 9.9 
               
               
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.5 
                 1.2 
                 16.7 
                 12.0 
                 10.7 
               
               
                 Uterus 
                 1.9 
                 3.4 
                 2.4 
                 4.2 
                 4.1 
               
               
                 Placenta 
                 1.6 
                 1.6 
                 1.8 
                 1.5 
                 1.4 
               
               
                 Prostate 
                 7.6 
                 3.2 
                 4.6 
                 2.9 
                 3.8 
               
               
                 Prostate ca.* (bone met)PC-3 
                 6.5 
                 7.0 
                 19.9 
                 17.2 
                 19.3 
               
               
                 Testis 
                 4.0 
                 3.3 
                 3.0 
                 1.0 
                 1.9 
               
               
                 Melanoma Hs688(A).T 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Melanoma* (met) Hs688(B).T 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Melanoma UACC-62 
                 0.2 
                 0.2 
                 1.0 
                 3.6 
                 3.8 
               
               
                 Melanoma M14 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Melanoma LOX IMVI 
                 0.5 
                 0.4 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Melanoma* (met) SK-MEL-5 
                 1.1 
                 0.2 
                 1.3 
                 2.2 
                 2.4 
               
               
                 Adipose 
                 9.7 
                 11.0 
                 32.8 
                 29.9 
                 31.4 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag1845, Run 148648438    
               
               
                   Column B - Rel. Exp. (%) Ag1845, Run 149951496    
               
               
                   Column C - Rel. Exp. (%) Ag2589, Run 167660070    
               
               
                   Column D - Rel. Exp. (%) Ag2621, Run 167644903    
               
               
                   Column E - Rel. Exp. (%) Ag2915, Run 167646705    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AII 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Normal Colon 
                 35.1 
                 24.5 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 19.3 
                 16.6 
               
               
                   
                 CC Margin (ODO3866) 
                 9.4 
                 11.9 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 14.0 
                 11.7 
               
               
                   
                 CC Margin (ODO3868) 
                 1.4 
                 1.9 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 9.6 
                 7.1 
               
               
                   
                 CC Margin (ODO3920) 
                 6.1 
                 8.0 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 58.2 
                 47.6 
               
               
                   
                 CC Margin (ODO3921) 
                 16.3 
                 8.2 
               
               
                   
                 CC from Partial Hepatectomy 
                 28.5 
                 22.5 
               
               
                   
                 (ODO4309) Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 18.4 
                 8.1 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 12.0 
                 15.7 
               
               
                   
                 Lung Margin (OD04451-02) 
                 6.5 
                 3.9 
               
               
                   
                 Normal Prostate 6546-1 
                 23.2 
                 17.3 
               
               
                   
                 Prostate Cancer (OD04410) 
                 29.5 
                 12.6 
               
               
                   
                 Prostate Margin (OD04410) 
                 18.3 
                 12.7 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 39.0 
                 28.9 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 32.8 
                 32.3 
               
               
                   
                 Normal Lung 061010 
                 47.3 
                 42.9 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 16.5 
                 19.6 
               
               
                   
                 Muscle Margin (ODO4286) 
                 3.5 
                 4.5 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 25.3 
                 26.2 
               
               
                   
                 Lung Margin (OD03126) 
                 9.5 
                 12.3 
               
               
                   
                 Lung Cancer (OD04404) 
                 19.8 
                 13.9 
               
               
                   
                 Lung Margin (OD04404) 
                 12.3 
                 10.1 
               
               
                   
                 Lung Cancer (OD04565) 
                 4.8 
                 3.8 
               
               
                   
                 Lung Margin (OD04565) 
                 13.7 
                 8.3 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 11.0 
                 9.9 
               
               
                   
                 Lung Margin (OD04237-02) 
                 21.0 
                 23.0 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 4.9 
                 3.5 
               
               
                   
                 Liver Margin (ODO4310) 
                 5.2 
                 4.0 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 1.3 
                 3.5 
               
               
                   
                 Lung Margin (OD04321) 
                 18.2 
                 23.7 
               
               
                   
                 Normal Kidney 
                 65.5 
                 50.3 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 49.0 
                 36.1 
               
               
                   
                 Kidney Margin (OD04338) 
                 48.3 
                 33.2 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 19.8 
                 14.0 
               
               
                   
                 Kidney Margin (OD04339) 
                 81.8 
                 65.1 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 100.0 
                 100.0 
               
               
                   
                 Kidney Margin (OD04340) 
                 82.4 
                 66.0 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 9.9 
                 9.9 
               
               
                   
                 Kidney Margin (OD04348) 
                 45.1 
                 42.6 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 24.3 
                 14.2 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 9.4 
                 10.0 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 6.5 
                 6.2 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 22.4 
                 33.0 
               
               
                   
                 Kidney Cancer 8120607 
                 33.4 
                 24.5 
               
               
                   
                 Kidney Margin 8120608 
                 44.4 
                 28.3 
               
               
                   
                 Kidney Cancer 8120613 
                 30.4 
                 17.8 
               
               
                   
                 Kidney Margin 8120614 
                 62.9 
                 51.8 
               
               
                   
                 Kidney Cancer 9010320 
                 36.3 
                 26.4 
               
               
                   
                 Kidney Margin 9010321 
                 46.7 
                 38.2 
               
               
                   
                 Normal Uterus 
                 2.1 
                 3.8 
               
               
                   
                 Uterus Cancer 064011 
                 17.8 
                 14.5 
               
               
                   
                 Normal Thyroid 
                 8.7 
                 5.0 
               
               
                   
                 Thyroid Cancer 064010 
                 10.2 
                 8.9 
               
               
                   
                 Thyroid Cancer A302152 
                 2.9 
                 4.5 
               
               
                   
                 Thyroid Margin A302153 
                 10.3 
                 7.3 
               
               
                   
                 Normal Breast 
                 18.0 
                 17.1 
               
               
                   
                 Breast Cancer (OD04566) 
                 15.7 
                 11.5 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 42.6 
                 49.7 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 42.6 
                 31.2 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 33.4 
                 23.3 
               
               
                   
                 Breast Cancer 064006 
                 15.6 
                 15.3 
               
               
                   
                 Breast Cancer 1024 
                 64.2 
                 49.0 
               
               
                   
                 Breast Cancer 9100266 
                 12.1 
                 12.2 
               
               
                   
                 Breast Margin 9100265 
                 17.7 
                 20.0 
               
               
                   
                 Breast Cancer A209073 
                 27.5 
                 33.2 
               
               
                   
                 Breast Margin A209073 
                 22.8 
                 27.7 
               
               
                   
                 Normal Liver 
                 14.4 
                 8.1 
               
               
                   
                 Liver Cancer 064003 
                 4.9 
                 4.1 
               
               
                   
                 Liver Cancer 1025 
                 9.3 
                 8.3 
               
               
                   
                 Liver Cancer 1026 
                 8.4 
                 8.8 
               
               
                   
                 Liver Cancer 6004-T 
                 10.2 
                 11.9 
               
               
                   
                 Liver Tissue 6004-N 
                 2.5 
                 2.0 
               
               
                   
                 Liver Cancer 6005-T 
                 7.3 
                 6.2 
               
               
                   
                 Liver Tissue 6005-N 
                 2.9 
                 3.2 
               
               
                   
                 Normal Bladder 
                 17.3 
                 15.2 
               
               
                   
                 Bladder Cancer 1023 
                 11.0 
                 12.3 
               
               
                   
                 Bladder Cancer A302173 
                 46.3 
                 47.0 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 65.1 
                 42.3 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 11.6 
                 6.7 
               
               
                   
                 Normal Ovary 
                 2.9 
                 2.3 
               
               
                   
                 Ovarian Cancer 064008 
                 32.5 
                 28.1 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 9.3 
                 8.0 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 8.8 
                 6.3 
               
               
                   
                 Normal Stomach 
                 15.4 
                 16.3 
               
               
                   
                 Gastric Cancer 9060358 
                 10.4 
                 4.0 
               
               
                   
                 Stomach Margin 9060359 
                 15.6 
                 20.6 
               
               
                   
                 Gastric Cancer 9060395 
                 25.9 
                 26.4 
               
               
                   
                 Stomach Margin 9060394 
                 35.8 
                 29.9 
               
               
                   
                 Gastric Cancer 9060397 
                 79.0 
                 64.2 
               
               
                   
                 Stomach Margin 9060396 
                 10.9 
                 8.4 
               
               
                   
                 Gastric Cancer 064005 
                 23.8 
                 27.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1845, Run 148648439    
               
               
                   
                   Column B - Rel. Exp. (%) Ag1845, Run 149957753    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AIJ 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 6.4 
               
               
                   
                 Secondary Th2 act 
                 3.5 
               
               
                   
                 Secondary Tr1 act 
                 0.6 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.8 
               
               
                   
                 Primary Th2 act 
                 6.3 
               
               
                   
                 Primary Tr1 act 
                 5.1 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 2.6 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 2.1 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.8 
               
               
                   
                 CD4 lymphocyte none 
                 0.4 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.7 
               
               
                   
                 LAK cells rest 
                 0.9 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.2 
               
               
                   
                 LAK cells PMA/ionomycin 
                 1.2 
               
               
                   
                 NK Cells IL-2 rest 
                 0.4 
               
               
                   
                 Two Way MLR 3 day 
                 2.1 
               
               
                   
                 Two Way MLR 5 day 
                 0.2 
               
               
                   
                 Two Way MLR 7 day 
                 0.8 
               
               
                   
                 PBMC rest 
                 2.2 
               
               
                   
                 PBMC PWM 
                 1.3 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 6.3 
               
               
                   
                 Ramos (B cell) ionomycin 
                 7.8 
               
               
                   
                 B lymphocytes PWM 
                 0.3 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 3.1 
               
               
                   
                 EOL-1 dbcAMP 
                 36.3 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 47.0 
               
               
                   
                 Dendritic cells none 
                 9.2 
               
               
                   
                 Dendritic cells LPS 
                 2.8 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.4 
               
               
                   
                 Monocytes rest 
                 0.4 
               
               
                   
                 Monocytes LPS 
                 5.5 
               
               
                   
                 Macrophages rest 
                 1.4 
               
               
                   
                 Macrophages LPS 
                 2.7 
               
               
                   
                 HUVEC none 
                 0.3 
               
               
                   
                 HUVEC starved 
                 1.0 
               
               
                   
                 HUVEC IL-1beta 
                 2.2 
               
               
                   
                 HUVEC IFN gamma 
                 1.2 
               
               
                   
                 HUVEC INF alpha + IFN gamma 
                 2.8 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 2.9 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 1.3 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 11.8 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 4.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.3 
               
               
                   
                 Small airway epithelium none 
                 0.0 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 1.0 
               
               
                   
                 Coronery artery SMC rest 
                 0.7 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 1.2 
               
               
                   
                 Astrocytes rest 
                 0.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 14.0 
               
               
                   
                 KU-812 (Basophil) rest 
                 2.5 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 1.3 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.2 
               
               
                   
                 Liver cirrhosis 
                 0.4 
               
               
                   
                 NCI-H292 none 
                 0.2 
               
               
                   
                 NCI-H292 IL-4 
                 0.5 
               
               
                   
                 NCI-H292 IL-9 
                 0.2 
               
               
                   
                 NCI-H292 IL-13 
                 0.8 
               
               
                   
                 NCI-H292 IFN gamma 
                 0.5 
               
               
                   
                 HPAEC none 
                 0.7 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 100.0 
               
               
                   
                 Lung fibroblast none 
                 0.0 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast IL-4 
                 0.0 
               
               
                   
                 Lung fibroblast IL-9 
                 0.0 
               
               
                   
                 Lung fibroblast IL-13 
                 0.0 
               
               
                   
                 Lung fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 6.4 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.6 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 0.0 
               
               
                   
                 Dermal Fibroblasts rest 
                 0.0 
               
               
                   
                 Neutrophils TNFa + LPS 
                 0.9 
               
               
                   
                 Neutrophils rest 
                 0.0 
               
               
                   
                 Colon 
                 0.0 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Thymus 
                 1.0 
               
               
                   
                 Kidney 
                 2.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp.(%) Ag8156, Run 319806134    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AIK 
               
             
            
               
                   
               
               
                   
               
               
                 general oncology screening panel_v_2.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Colon cancer 1 
                 26.6 
               
               
                   
                 Colon NAT 1 
                 5.8 
               
               
                   
                 Colon cancer 2 
                 7.1 
               
               
                   
                 Colon NAT 2 
                 3.6 
               
               
                   
                 Colon cancer 3 
                 26.6 
               
               
                   
                 Colon NAT 3 
                 7.3 
               
               
                   
                 Colon malignant cancer 4 
                 23.8 
               
               
                   
                 Colon NAT 4 
                 1.5 
               
               
                   
                 Lung cancer 1 
                 5.8 
               
               
                   
                 Lung NAT 1 
                 1.3 
               
               
                   
                 Lung cancer 2 
                 42.6 
               
               
                   
                 Lung NAT 2 
                 1.7 
               
               
                   
                 Squamous cell carcinoma 3 
                 10.0 
               
               
                   
                 Lung NAT 3 
                 0.6 
               
               
                   
                 Metastatic melanoma 1 
                 3.1 
               
               
                   
                 Melanoma 2 
                 6.4 
               
               
                   
                 Melanoma 3 
                 3.3 
               
               
                   
                 Metastatic melanoma 4 
                 4.6 
               
               
                   
                 Metastatic melanoma 5 
                 6.0 
               
               
                   
                 Bladder cancer 1 
                 0.3 
               
               
                   
                 Bladder NAT 1 
                 0.0 
               
               
                   
                 Bladder cancer 2 
                 0.8 
               
               
                   
                 Bladder NAT 2 
                 0.2 
               
               
                   
                 Bladder NAT 3 
                 0.3 
               
               
                   
                 Bladder NAT 4 
                 3.8 
               
               
                   
                 Prostate adenocarcinoma 1 
                 4.4 
               
               
                   
                 Prostate adenocarcinoma 2 
                 0.9 
               
               
                   
                 Prostate adenocarcinoma 3 
                 3.4 
               
               
                   
                 Prostate adenocarcinoma 4 
                 8.0 
               
               
                   
                 Prostate NAT 5 
                 2.2 
               
               
                   
                 Prostate adenocarcinoma 6 
                 0.8 
               
               
                   
                 Prostate adenocarcinoma 7 
                 2.9 
               
               
                   
                 Prostate adenocarcinoma 8 
                 0.4 
               
               
                   
                 Prostate adenocarcinoma 9 
                 12.4 
               
               
                   
                 Prostate NAT 10 
                 0.4 
               
               
                   
                 Kidney cancer 1 
                 24.0 
               
               
                   
                 Kidney NAT 1 
                 9.6 
               
               
                   
                 Kidney cancer 2 
                 100.0 
               
               
                   
                 Kidney NAT 2 
                 13.5 
               
               
                   
                 Kidney cancer 3 
                 31.0 
               
               
                   
                 Kidney NAT 3 
                 11.8 
               
               
                   
                 Kidney cancer 4 
                 27.0 
               
               
                   
                 Kidney NAT 4 
                 13.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%)Ag2915, Run 260443054    
               
            
           
         
       
     
      AI_comprehensive panel_v1.0 Summary: Ag1845 This transcript was expressed at low levels in many different disease tissues. In comparison, normal lung and joint tissues expressed none or extremely low levels of this transcript. Since this transcript was expressed in monocytes, and matched control tissues contain these inflammatory cells (psoriasis, Crohn&#39;s and ulcerative colitis), this transcript is detected at these sites. This transcript encodes B7-H2, which has been shown to be important in antigen presentation. It is a ligand for ICOS and serves as a costimulatory molecule. Therapeutics designed with the transcript are useful for the reduction or inhibition of antigen presentation and in the treatment of diseases such as asthma, IBD, psoriasis and arthritis in which T cells are chronically stimulated.  
      CNS_neurodegeneration_v1.0 Summary: Ag1845/Ag2589/Ag2621/Ag2915 The expression of this gene was up-regulated in the temporal cortex of Alzheimer&#39;s disease patients when compared to non-demented controls. This difference was apparent when the data were analyzed via ANCOVA, using overall RNA quality and/or quantity as a covariate. The up-regulation of this gene was most apparent in the variant detected by Ag1845. The temporal cortex is a region that shows degeneration at the mid-stages of this disease. Thus, the phenomenon of neurodegeneration was captured in this region, as opposed to the hippocampus and entorhinal cortex where a large number of neurons are already lost by the time of death in AD. Furthermore, in the occipital cortex (where neurodegeneration does not occur in Alzheimer&#39;s) this gene was not found to be up-regulated in the same patients. Taken together, these data demonstrate that this gene is useful as a marker of Alzheimer&#39;s-like neurodegeneration, and is involved in the process of neurodegeneration. This gene is a form of the B7 protein (B7-H2B), which plays a role in inflammation. Neuroinflammation has been implicated in AD, to the extent that long-term usage of anti-inflammatory agents has been correlated with a reduced incidence of Alzheimer&#39;s in retrospective studies. This gene therefore represents an excellent drug target for the treatment of Alzheimer&#39;s disease, and any other neuroinflammatory condition.  
      Panel 1.3D Summary: Ag1845/Ag2589/Ag2621/Ag2915 Highest expression of this gene was seen in the brain, fetal kidney, and a breast cancer cell line. Higher levels of expression were also consistently seen in fetal skeletal muscle (CTs=29-30), when compared to expression in adult skeletal muscle (CTs=33-35). Thus, expression of this gene is useful as a marker to differentiate between the adult and fetal sources of this tissue. The relative overexpression of this gene in fetal sekeltal muscle shows that the protein product enhances muscle growth or development in the fetus and also acts in a regenerative capacity in the adult. Therapeutic modulation of the protein encoded by this gene is useful in the treatment of lung related diseases.  
      This gene product was also moderately expressed in pancreas, adrenal, thyroid, pituitary, adult and fetal liver, adult and fetal heart, and adipose. Based on its expression profile in metabolic tissues, this gene product is useful in the diagnosis and/or treatment of metabolic disease, including obesity and diabetes.  
      Panel 2D Summary: Ag1845 The expression of this gene was highest in a sample derived from a kidney cancer (CTs=28). There was substantial expression associated with other samples derived from kidney tissue, bladder cancer and breast cancer. The expression of this gene is useful as a marker to distinguish this kidney cancer sample from other samples in the panel. Therapeutic modulation of this gene, through the use of small molecule drugs, protein therapeutics or antibodies is beneficial for the treatment of kidney cancer, breast cancer or bladder cancer.  
      Panel 4.1D Summary: Ag8156 Highest expression of this gene was detected in TNF alpha+IL-1 beta activated HPAEC cells (CT=30.9). Low expression of this gene was also seen in activated lung microvascular endothelial cells. Expression of this gene was very low or undetectable in resting endothelial cells. Low expression of this gene was also seen in activated astrocytes, eosinophils, Ramos B cells, and activated primary Th2 and secondary Th1 cells. This gene codes for B7-H2B gene. B7-H2 is a recently cloned costimulatory ligand that belongs to B7 family. B7-H2 binds to ICOS, an inducible costimulatory receptor expressed on activated, but not resting T cells. (Wang S, Blood 2000 October 15;96(8):2808-13) Interaction of B7-H2 and ICOS in the presence of the TCR stimuli results in an augmented proliferative responses and cytokine production. The data show that circumstances B7-H2 more effectively costimulates Th2 responses. The B7-H2/ICOS pathway plays an important role in antibody response and germinal center formation. (Tesciuba. J Immunol 2001 August 15;167(4):1996-2003) Thus, B7-H2 is useful in the generation of therapeutics for diseases with antibody-mediated and Th2-mediated pathogenesis. Also, antibodies and small molecules that antagonize the function of the B7-H2B protein are useful for the reduction or elimination of the symptoms in patients with autoimmune and inflammatory diseases that involve endothelial cells, such as lupus erythematosus, asthma, emphysema, Crohn&#39;s disease, ulcerative colitis, rheumatoid arthritis, osteoarthritis, and psoriasis.  
      general oncology screening panel_v — 2.4 Summary: Ag2915 Highest expression of this gene was detected in a kidney cancer sample (CT=28.2). Moderate to low expression of this gene was also seen in cancer and normal samples derived from kidney, colon, metastatic melanoma, prostate and lung. Expression of this gene was higher in cancer samples. Therefore, expression of this gene is useful as a diagnostic marker to detect the presence of these cancers. Therapeutic modulation of this gene or its protein product through the use of antibodies or small molecule drug is useful in the treatment of kidney, colon, metastatic melanoma, prostate and lung cancers.  
      AJ. CG55906-01: S3-12  
      Expression of gene CG55906-01 was assessed using the primer-probe sets Ag2840 and Ag6179, described in Tables AJA and AJB. Results of the RTQ-PCR runs are shown in Tables AJC, AMD, AME, AJF and AJG.  
               TABLE AJA                          Probe Name Ag2840                                                 Start   SEQ ID           Primers   Sequences   Length   Position   No                                             Forward   5′-tctatggtcatgggtacgaaag-3′   22   1190   1444                   Probe   TET-5′-acacgatgtccactgggctcacag-3′-   24   1212   1445           TAMRA               Reverse   5′-gttgtgttcagcccagtttg-3′   20   1265   1446                  
 
     
       
         
           
               
             
               
                 TABLE AJB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag6179 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-ttctcactatgtctgctcca-3′ 
                 20 
                 123 
                 1447 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-atgcagaccctgggcagcttct-3′-TAMRA 
                 22 
                 194 
                 1448 
               
               
                   
               
               
                 Reverse 
                 5′-ttccgggcagagctgaa-3′ 
                 17 
                 233 
                 1449 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AJC 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.5 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 73.7 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma* M14 
                 0.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.2 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.0 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.0 
               
               
                   
                 Testis Pool 
                 0.9 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 5.1 
               
               
                   
                 Prostate Pool 
                 2.6 
               
               
                   
                 Placenta 
                 0.1 
               
               
                   
                 Uterus Pool 
                 1.3 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.3 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 3.4 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.1 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.3 
               
               
                   
                 Ovary 
                 0.7 
               
               
                   
                 Breast ca. MCF-7 
                 0.1 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca. BT 549 
                 0.0 
               
               
                   
                 Breast ca. T47D 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Breast Pool 
                 6.7 
               
               
                   
                 Trachea 
                 5.0 
               
               
                   
                 Lung 
                 0.2 
               
               
                   
                 Fetal Lung 
                 0.1 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.1 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.1 
               
               
                   
                 Lung ca. A549 
                 0.0 
               
               
                   
                 Lung ca. NCI-H526 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 0.1 
               
               
                   
                 Lung ca. NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. HOP-62 
                 0.0 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
               
               
                   
                 Liver 
                 0.8 
               
               
                   
                 Fetal Liver 
                 0.9 
               
               
                   
                 Liver ca. HepG2 
                 1.4 
               
               
                   
                 Kidney Pool 
                 13.7 
               
               
                   
                 Fetal Kidney 
                 0.1 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 1.0 
               
               
                   
                 Bladder 
                 6.5 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 1.7 
               
               
                   
                 Gastric ca. KATO III 
                 0.3 
               
               
                   
                 Colon ca. SW-948 
                 0.1 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.8 
               
               
                   
                 Colon ca. HCT-116 
                 0.4 
               
               
                   
                 Colon ca. CaCo-2 
                 0.1 
               
               
                   
                 Colon cancer tissue 
                 17.6 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 7.7 
               
               
                   
                 Small Intestine Pool 
                 6.1 
               
               
                   
                 Stomach Pool 
                 3.7 
               
               
                   
                 Bone Marrow Pool 
                 1.7 
               
               
                   
                 Fetal Heart 
                 0.8 
               
               
                   
                 Heart Pool 
                 7.9 
               
               
                   
                 Lymph Node Pool 
                 9.1 
               
               
                   
                 Fetal Skeletal Muscle 
                 2.5 
               
               
                   
                 Skeletal Muscle Pool 
                 100.0 
               
               
                   
                 Spleen Pool 
                 0.0 
               
               
                   
                 Thymus Pool 
                 5.9 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 0.1 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.0 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 0.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.3 
               
               
                   
                 Brain (Amygdala) Pool 
                 0.8 
               
               
                   
                 Brain (cerebellum) 
                 0.7 
               
               
                   
                 Brain (fetal) 
                 0.1 
               
               
                   
                 Brain (Hippocampus) Pool 
                 0.8 
               
               
                   
                 Cerebral Cortex Pool 
                 0.5 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 0.9 
               
               
                   
                 Brain (Thalamus) Pool 
                 0.8 
               
               
                   
                 Brain (whole) 
                 0.2 
               
               
                   
                 Spinal Cord Pool 
                 3.5 
               
               
                   
                 Adrenal Gland 
                 3.7 
               
               
                   
                 Pituitary gland Pool 
                 0.0 
               
               
                   
                 Salivary Gland 
                 1.8 
               
               
                   
                 Thyroid (female) 
                 0.5 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 1.0 
               
               
                   
                 Pancreas Pool 
                 1.8 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp.(%) Ag6179, Run 256555247    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AJD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 41.8 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 4.3 
               
               
                   
                 CC Margin (ODO3866) 
                 6.9 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 1.1 
               
               
                   
                 CC Margin (ODO3868) 
                 4.5 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 0.0 
               
               
                   
                 CC Margin (ODO3920) 
                 0.0 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 0.4 
               
               
                   
                 CC Margin (ODO3921) 
                 2.5 
               
               
                   
                 CC from Partial Hepatectomy (ODO4309) 
                 0.2 
               
               
                   
                 Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 1.8 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 0.1 
               
               
                   
                 Lung Margin (OD04451-02) 
                 0.1 
               
               
                   
                 Normal Prostate 6546-1 
                 0.9 
               
               
                   
                 Prostate Cancer (OD04410) 
                 1.2 
               
               
                   
                 Prostate Margin (OD04410) 
                 3.2 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 0.8 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 1.9 
               
               
                   
                 Normal Lung 061010 
                 1.4 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 0.5 
               
               
                   
                 Muscle Margin (ODO4286) 
                 16.4 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 0.1 
               
               
                   
                 Lung Margin (OD03126) 
                 0.4 
               
               
                   
                 Lung Cancer (OD04404) 
                 0.3 
               
               
                   
                 Lung Margin (OD04404) 
                 0.3 
               
               
                   
                 Lung Cancer (OD04565) 
                 0.0 
               
               
                   
                 Lung Margin (OD04565) 
                 0.2 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 0.0 
               
               
                   
                 Lung Margin (OD04237-02) 
                 0.1 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 0.4 
               
               
                   
                 Liver Margin (ODO4310) 
                 2.6 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.0 
               
               
                   
                 Lung Margin (OD04321) 
                 0.2 
               
               
                   
                 Normal Kidney 
                 3.1 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04338) 
                 0.0 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 0.2 
               
               
                   
                 Kidney Margin (OD04339) 
                 1.1 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 0.3 
               
               
                   
                 Kidney Margin (OD04340) 
                 1.8 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04348) 
                 1.3 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 0.0 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.1 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 1.2 
               
               
                   
                 Kidney Cancer 8120607 
                 0.1 
               
               
                   
                 Kidney Margin 8120608 
                 0.2 
               
               
                   
                 Kidney Cancer 8120613 
                 0.7 
               
               
                   
                 Kidney Margin 8120614 
                 2.0 
               
               
                   
                 Kidney Cancer 9010320 
                 8.4 
               
               
                   
                 Kidney Margin 9010321 
                 2.0 
               
               
                   
                 Normal Uterus 
                 2.4 
               
               
                   
                 Uterus Cancer 064011 
                 4.4 
               
               
                   
                 Normal Thyroid 
                 2.3 
               
               
                   
                 Thyroid Cancer 064010 
                 0.0 
               
               
                   
                 Thyroid Cancer A302152 
                 0.4 
               
               
                   
                 Thyroid Margin A302153 
                 0.5 
               
               
                   
                 Normal Breast 
                 80.7 
               
               
                   
                 Breast Cancer (OD04566) 
                 1.5 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 21.0 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 100.0 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 13.3 
               
               
                   
                 Breast Cancer 064006 
                 0.9 
               
               
                   
                 Breast Cancer 1024 
                 5.8 
               
               
                   
                 Breast Cancer 9100266 
                 3.2 
               
               
                   
                 Breast Margin 9100265 
                 5.9 
               
               
                   
                 Breast Cancer A209073 
                 2.0 
               
               
                   
                 Breast Margin A209073 
                 7.9 
               
               
                   
                 Normal Liver 
                 3.3 
               
               
                   
                 Liver Cancer 064003 
                 2.2 
               
               
                   
                 Liver Cancer 1025 
                 6.0 
               
               
                   
                 Liver Cancer 1026 
                 2.0 
               
               
                   
                 Liver Cancer 6004-T 
                 7.5 
               
               
                   
                 Liver Tissue 6004-N 
                 2.2 
               
               
                   
                 Liver Cancer 6005-T 
                 1.8 
               
               
                   
                 Liver Tissue 6005-N 
                 0.3 
               
               
                   
                 Normal Bladder 
                 6.0 
               
               
                   
                 Bladder Cancer 1023 
                 0.7 
               
               
                   
                 Bladder Cancer A302173 
                 0.4 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 0.1 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 11.7 
               
               
                   
                 Normal Ovary 
                 0.8 
               
               
                   
                 Ovarian Cancer 064008 
                 1.1 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 0.7 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 2.9 
               
               
                   
                 Normal Stomach 
                 15.1 
               
               
                   
                 Gastric Cancer 9060358 
                 6.4 
               
               
                   
                 Stomach Margin 9060359 
                 2.0 
               
               
                   
                 Gastric Cancer 9060395 
                 8.8 
               
               
                   
                 Stomach Margin 9060394 
                 8.4 
               
               
                   
                 Gastric Cancer 9060397 
                 0.9 
               
               
                   
                 Stomach Margin 9060396 
                 3.1 
               
               
                   
                 Gastric Cancer 064005 
                 5.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp.(%) Ag2840, Run 161922469    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AJE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Daoy- Medulloblastoma 
                 22.1 
               
               
                   
                 TE671- Medulloblastoma 
                 10.1 
               
               
                   
                 D283 Med- Medulloblastoma 
                 2.3 
               
               
                   
                 PFSK-1- Primitive Neuroectodermal 
                 6.2 
               
               
                   
                 XF-498- CNS 
                 8.4 
               
               
                   
                 SNB-78- Glioma 
                 5.0 
               
               
                   
                 SF-268- Glioblastoma 
                 1.4 
               
               
                   
                 T98G- Glioblastoma 
                 0.0 
               
               
                   
                 SK-N-SH- Neuroblastoma (metastasis) 
                 2.7 
               
               
                   
                 SF-295- Glioblastoma 
                 2.9 
               
               
                   
                 Cerebellum 
                 3.4 
               
               
                   
                 Cerebellum 
                 38.2 
               
               
                   
                 NCI-H292- Mucoepidermoid lung 
                 0.0 
               
               
                   
                 carcinoma 
               
               
                   
                 DMS-114- Small cell lung cancer 
                 0.0 
               
               
                   
                 DMS-79- Small cell lung cancer 
                 100.0 
               
               
                   
                 NCI-H146- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H526- Small cell lung cancer 
                 9.6 
               
               
                   
                 NCI-N417- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H82- Small cell lung cancer 
                 3.3 
               
               
                   
                 NCI-H157- Squamous cell lung cancer 
                 0.0 
               
               
                   
                 (metastasis) 
               
               
                   
                 NCI-H1155- Large cell lung cancer 
                 20.6 
               
               
                   
                 NCI-H1299- Large cell lung cancer 
                 9.2 
               
               
                   
                 NCI-H727- Lung carcinoid 
                 0.0 
               
               
                   
                 NCI-UMC-11- Lung carcinoid 
                 0.0 
               
               
                   
                 LX-1- Small cell lung cancer 
                 7.9 
               
               
                   
                 Colo-205- Colon cancer 
                 0.0 
               
               
                   
                 KM12- Colon cancer 
                 0.0 
               
               
                   
                 KM20L2- Colon cancer 
                 2.9 
               
               
                   
                 NCI-H716- Colon cancer 
                 0.0 
               
               
                   
                 SW-48- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW1116- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 LS 174T- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-948- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-480- Colon adenocarcinoma 
                 3.8 
               
               
                   
                 NCI-SNU-5- Gastric carcinoma 
                 2.1 
               
               
                   
                 KATO III- Gastric carcinoma 
                 12.0 
               
               
                   
                 NCI-SNU-16- Gastric carcinoma 
                 5.8 
               
               
                   
                 NCI-SNU-1- Gastric carcinoma 
                 2.6 
               
               
                   
                 RF-1- Gastric adenocarcinoma 
                 0.0 
               
               
                   
                 RF-48- Gastric adenocarcinoma 
                 7.2 
               
               
                   
                 MKN-45- Gastric carcinoma 
                 96.6 
               
               
                   
                 NCI-N87- Gastric carcinoma 
                 10.0 
               
               
                   
                 OVCAR-5- Ovarian carcinoma 
                 3.7 
               
               
                   
                 RL95-2- Uterine carcinoma 
                 7.2 
               
               
                   
                 HelaS3- Cervical adenocarcinoma 
                 0.0 
               
               
                   
                 Ca Ski- Cervical epidermoid carcinoma 
                 7.6 
               
               
                   
                 (metastasis) 
               
               
                   
                 ES-2- Ovarian clear cell carcinoma 
                 0.0 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 0.0 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 0.0 
               
               
                   
                 MEG-01- Chronic myelogenous leukemia 
                 0.0 
               
               
                   
                 (megokaryoblast) 
               
               
                   
                 Raji- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 Daudi- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 U266- B-cell plasmacytoma 
                 10.4 
               
               
                   
                 CA46- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 5.9 
               
               
                   
                 JM1- pre-B-cell lymphoma 
                 7.8 
               
               
                   
                 Jurkat- T cell leukemia 
                 2.7 
               
               
                   
                 TF-1- Erythroleukemia 
                 5.0 
               
               
                   
                 HUT 78- T-cell lymphoma 
                 0.0 
               
               
                   
                 U937- Histiocytic lymphoma 
                 11.0 
               
               
                   
                 KU-812- Myelogenous leukemia 
                 31.0 
               
               
                   
                 769-P- Clear cell renal carcinoma 
                 6.1 
               
               
                   
                 Caki-2- Clear cell renal carcinoma 
                 3.0 
               
               
                   
                 SW 839- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 Rhabdoid kidney tumor 
                 3.7 
               
               
                   
                 Hs766T- Pancreatic carcinoma (LN 
                 9.8 
               
               
                   
                 metastasis) 
               
               
                   
                 CAPAN-1- Pancreatic adenocarcinoma (liver 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 SU86.86- Pancreatic carcinoma (liver 
                 5.0 
               
               
                   
                 metastasis) 
               
               
                   
                 BxPC-3- Pancreatic adenocarcinoma 
                 13.0 
               
               
                   
                 HPAC- Pancreatic adenocarcinoma 
                 20.7 
               
               
                   
                 MIA PaCa-2- Pancreatic carcinoma 
                 4.2 
               
               
                   
                 CFPAC-1- Pancreatic ductal adenocarcinoma 
                 13.9 
               
               
                   
                 PANC-1- Pancreatic epithelioid ductal 
                 69.7 
               
               
                   
                 carcinoma 
               
               
                   
                 T24- Bladder carcinma (transitional cell) 
                 0.0 
               
               
                   
                 5637- Bladder carcinoma 
                 0.0 
               
               
                   
                 HT-1197- Bladder carcinoma 
                 6.4 
               
               
                   
                 UM-UC-3- Bladder carcinma (transitional cell) 
                 2.4 
               
               
                   
                 A204- Rhabdomyosarcoma 
                 12.5 
               
               
                   
                 HT-1080- Fibrosarcoma 
                 12.1 
               
               
                   
                 MG-63- Osteosarcoma 
                 0.0 
               
               
                   
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 16.7 
               
               
                   
                 SJRH30- Rhabdomyosarcoma (met to bone 
                 5.7 
               
               
                   
                 marrow) 
               
               
                   
                 A431- Epidermoid carcinoma 
                 0.0 
               
               
                   
                 WM266-4- Melanoma 
                 0.0 
               
               
                   
                 DU 145- Prostate carcinoma (brain 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 MDA-MB-468- Breast adenocarcinoma 
                 11.4 
               
               
                   
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-9- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 CAL 27- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp.(%) Ag2840, Run 170190088    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AJF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 6.4 
               
               
                   
                 Secondary Th2 act 
                 2.0 
               
               
                   
                 Secondary Tr1 act 
                 4.0 
               
               
                   
                 Secondary Th1 rest 
                 4.4 
               
               
                   
                 Secondary Th2 rest 
                 13.9 
               
               
                   
                 Secondary Tr1 rest 
                 8.2 
               
               
                   
                 Primary Th1 act 
                 3.0 
               
               
                   
                 Primary Th2 act 
                 9.6 
               
               
                   
                 Primary Tr1 act 
                 1.6 
               
               
                   
                 Primary Th1 rest 
                 3.2 
               
               
                   
                 Primary Th2 rest 
                 5.6 
               
               
                   
                 Primary Tr1 rest 
                 6.4 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 6.0 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 6.2 
               
               
                   
                 CD8 lymphocyte act 
                 6.4 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 2.4 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 12.5 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 11.3 
               
               
                   
                 LAK cells rest 
                 7.6 
               
               
                   
                 LAK cells IL-2 
                 4.2 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 1.9 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 2.7 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 6.6 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 3.4 
               
               
                   
                 Two Way MLR 3 day 
                 6.7 
               
               
                   
                 Two Way MLR 5 day 
                 5.8 
               
               
                   
                 Two Way MLR 7 day 
                 8.5 
               
               
                   
                 PBMC rest 
                 9.3 
               
               
                   
                 PBMC PWM 
                 1.0 
               
               
                   
                 PBMC PHA-L 
                 3.2 
               
               
                   
                 Ramos (B cell) none 
                 1.9 
               
               
                   
                 Ramos (B cell) ionomycin 
                 3.0 
               
               
                   
                 B lymphocytes PWM 
                 1.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 9.4 
               
               
                   
                 EOL-1 dbcAMP 
                 0.8 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 6.0 
               
               
                   
                 Dendritic cells none 
                 0.9 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 3.1 
               
               
                   
                 Monocytes rest 
                 13.8 
               
               
                   
                 Monocytes LPS 
                 4.9 
               
               
                   
                 Macrophages rest 
                 2.1 
               
               
                   
                 Macrophages LPS 
                 0.9 
               
               
                   
                 HUVEC none 
                 6.3 
               
               
                   
                 HUVEC starved 
                 7.9 
               
               
                   
                 HUVEC IL-1beta 
                 0.9 
               
               
                   
                 HUVEC IFN gamma 
                 4.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 5.4 
               
               
                   
                 HUVEC IL-11 
                 3.8 
               
               
                   
                 Lung Microvascular EC none 
                 8.4 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 4.0 
               
               
                   
                 Microvascular Dermal EC none 
                 4.5 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 10.4 
               
               
                   
                 Small airway epithelium none 
                 5.9 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 8.5 
               
               
                   
                 Coronery artery SMC rest 
                 0.0 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 1.0 
               
               
                   
                 Astrocytes rest 
                 0.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 1.4 
               
               
                   
                 KU-812 (Basophil) rest 
                 8.4 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 6.1 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 6.7 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 1.8 
               
               
                   
                 Liver cirrhosis 
                 63.3 
               
               
                   
                 NCI-H292 none 
                 0.0 
               
               
                   
                 NCI-H292 IL-4 
                 0.0 
               
               
                   
                 NCI-H292 IL-9 
                 0.0 
               
               
                   
                 NCI-H292 IL-13 
                 0.0 
               
               
                   
                 NCI-H292 IFN gamma 
                 0.0 
               
               
                   
                 HPAEC none 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 3.3 
               
               
                   
                 Lung fibroblast none 
                 29.5 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 8.2 
               
               
                   
                 Lung fibroblast IL-4 
                 7.9 
               
               
                   
                 Lung fibroblast IL-9 
                 10.3 
               
               
                   
                 Lung fibroblast IL-13 
                 4.2 
               
               
                   
                 Lung fibroblast IFN gamma 
                 9.1 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 2.3 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 9.2 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1beta 
                 4.9 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 1.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 8.1 
               
               
                   
                 Dermal Fibroblasts rest 
                 4.2 
               
               
                   
                 Neutrophils TNFa + LPS 
                 25.0 
               
               
                   
                 Neutrophils rest 
                 66.9 
               
               
                   
                 Colon 
                 100.0 
               
               
                   
                 Lung 
                 3.8 
               
               
                   
                 Thymus 
                 24.5 
               
               
                   
                 Kidney 
                 32.1 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp.(%) Ag2840, Run 204964146    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AJG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 5 Islet 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 97457_Patient-02go_adipose 
                 100.0 
               
               
                   
                 97476_Patient-07sk_skeletal muscle 
                 22.8 
               
               
                   
                 97477_Patient-07ut_uterus 
                 13.8 
               
               
                   
                 97478_Patient-07pl_placenta 
                 0.0 
               
               
                   
                 99167_Bayer Patient 1 
                 1.0 
               
               
                   
                 97482_Patient-08ut_uterus 
                 6.1 
               
               
                   
                 97483_Patient-08pl_placenta 
                 0.0 
               
               
                   
                 97486_Patient-09sk_skeletal muscle 
                 2.3 
               
               
                   
                 97487_Patient-09ut_uterus 
                 5.5 
               
               
                   
                 97488_Patient-09pl_placenta 
                 0.0 
               
               
                   
                 97492_Patient-10ut_uterus 
                 4.4 
               
               
                   
                 97493_Patient-10pl_placenta 
                 0.0 
               
               
                   
                 97495_Patient-11go_adipose 
                 24.3 
               
               
                   
                 97496_Patient-11sk_skeletal muscle 
                 13.0 
               
               
                   
                 97497_Patient-11ut_uterus 
                 11.7 
               
               
                   
                 97498_Patient-11pl_placenta 
                 0.0 
               
               
                   
                 97500_Patient-12go_adipose 
                 78.5 
               
               
                   
                 97501_Patient-12sk_skeletal muscle 
                 63.3 
               
               
                   
                 97502_Patient-12ut_uterus 
                 13.0 
               
               
                   
                 97503_Patient-12pl_placenta 
                 0.0 
               
               
                   
                 94721_Donor 2 U - A_Mesenchymal 
                 0.0 
               
               
                   
                 Stem Cells 
               
               
                   
                 94722_Donor 2 U - B_Mesenchymal 
                 0.0 
               
               
                   
                 Stem Cells 
               
               
                   
                 94723_Donor 2 U - C_Mesenchymal 
                 0.0 
               
               
                   
                 Stem Cells 
               
               
                   
                 94709_Donor 2 AM - A_adipose 
                 18.9 
               
               
                   
                 94710_Donor 2 AM - B_adipose 
                 12.5 
               
               
                   
                 94711_Donor 2 AM - C_adipose 
                 15.2 
               
               
                   
                 94712_Donor 2 AD - A_adipose 
                 25.2 
               
               
                   
                 94713_Donor 2 AD - B_adipose 
                 30.4 
               
               
                   
                 94714_Donor 2 AD - C_adipose 
                 42.3 
               
               
                   
                 94742_Donor 3 U - A_Mesenchymal Stem 
                 0.0 
               
               
                   
                 Cells 
               
               
                   
                 94743_Donor 3 U - B_Mesenchymal Stem 
                 0.0 
               
               
                   
                 Cells 
               
               
                   
                 94730_Donor 3 AM - A_adipose 
                 12.6 
               
               
                   
                 94731_Donor 3 AM - B_adipose 
                 7.9 
               
               
                   
                 94732_Donor 3 AM - C_adipose 
                 11.0 
               
               
                   
                 94733_Donor 3 AD - A_adipose 
                 26.8 
               
               
                   
                 94734_Donor 3 AD - B_adipose 
                 18.0 
               
               
                   
                 94735_Donor 3 AD - C_adipose 
                 17.1 
               
               
                   
                 77138_Liver_HepG2untreated 
                 0.3 
               
               
                   
                 73556_Heart_Cardiac stromal cells 
                 0.0 
               
               
                   
                 (primary) 
               
               
                   
                 81735_Small Intestine 
                 12.9 
               
               
                   
                 72409_Kidney_Proximal Convoluted Tubule 
                 0.0 
               
               
                   
                 82685_Small intestine_Duodenum 
                 1.0 
               
               
                   
                 90650_Adrenal_Adrenocortical adenoma 
                 0.0 
               
               
                   
                 72410_Kidney_HRCE 
                 0.0 
               
               
                   
                 72411_Kidney_HRE 
                 0.0 
               
               
                   
                 73139_Uterus_Uterine smooth muscle cells 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp.(%) Ag6179, Run 256791278    
               
            
           
         
       
     
      General_screening_panel_v1.5 Summary: Ag6179 Highest expression of this gene was detected in skeletal muscle (CT=28.6). Moderate levels of expression of this gene are also seen in adipose, colon, small intestine and heart. This gene codes for a homolog of mouse S3-12 protein. S3-12 is a purported adipose cell membrane-associated protein that is upregulated during adipocyte differentiation. Due to its weak homology with adipophilins, this gene is involved in lipid uptake. Inhibiting its action by an antibody is useful for reducing the potential white adipose mass by limiting lipid uptake and inhibiting adipocyte differentiation. Its expression in skeletal muscle shows that it can function similarly in muscle tissue as well, in terms of lipid uptake. Since excess lipid storage in muscle is associated with insulin resistance, antibody inhibition of this gene product is useful as a treatment for the prevention of obesity-associated insulin resistance.  
      Furthermore, this gene product was also moderately expressed in a variety of metabolic tissues, including adrenal gland, heart, colon and small intestine. Thus, modulation of this gene or expressed protein is useful as marker for the treatment of metabolic disease, including Types 1 and 2 diabetes, and obesity.  
      In addition, moderate but significant expression in the spinal cordshows that the protein encoded by this gene plays a role in lipid processing in the central nervous system. LDLR has been implicated in the development of Alzheimer&#39;s disease. Therefore, modulation of this gene or gene product is useful in the treatment of Alzheimer&#39;s Disease.  
      Panel 2D Summary: Ag2840 This gene was moderately expressed in all tissue samples this panel, with highest expression in a metastatic breast cancer sample (CT=24.5). This gene showed higher expression in normal kidney, prostate, colon and bladder samples relative to the corresponding adjacent tumor sample. Expression of this gene is useful as a marker to differentiate between normal and cancerous tissues. Therapeutic modulation of this gene, expressed protein and/or use of agonists targeting this gene or gene product is useful in the treatment of kidney, prostate, colon and bladder cancers.  
      Panel 3D Summary: Ag2840 This gene showed low levels of expression in cancer cell lines, with highest expression in a gastric cancer MKN-45 cell line (CT=32). Significant expression was seen in cancer cell lines derived from lung cancer, pancreatic cancer and a leukemia. Therapeutic modulation of this gene, expressed protein and/or use of antibodies or small molecule drug targeting this gene or gene product is useful in the treatment of these cancers.  
      Panel 4.1D Summary: Ag2840 This transcript is expressed in colon and in resting neutrophils (CTs=31-33). Thus, the transcript or the protein it encodes is useful as a marker to detect colon tissue and neutrophils. Therapeutics modulation of this gene, expressed protein and/or use of antibodies or small molecule targeting this gene or gene product are useful in the treatment of autoimmune and inflammatory diseases such as asthma, allergies, inflammatory bowel disease including Crohn&#39;s and Colitis, lupus erythematosus, psoriasis, rheumatoid arthritis, and osteoarthritis.  
      Panel 5 Islet Summary: Ag6179 Highest expression of this gene was detected in adipose tissue from a diabetic patient. Significant expression of this gene was also seen in midway and fully differentiated adipose tissue. This gene was moderately expressed in clinical specimens of adipose, skeletal muscle and uterus.  
      AK. CG5590602 and CG5590604 and CG5590605: Human Ortholog of Mouse S3-12  
      Expression of full-length physical clone CG55906-02 and variants CG55906-04 and CG55906-05 was assessed using the primer-probe sets Ag2840, Ag5976 and Ag6345, described in Tables AKA, AKB and AKC. Results of the RTQ-PCR runs are shown in Tables AKD, AKE, AKF, AKG and AKH. Please note that only the probe and primer set Ag6345 corresponds to CG55906-02 and only probe and primer sets Ag5976 and Ag6345 correspond to CG55906-05.  
               TABLE AKA                          Probe Name Ag2840                                                 Start   SEQ ID           Primers   Sequences   Length   Position   No                                             Forward   5′-tctatggtcatgggtacgaaag-3′   22   1183   1450                   Probe   TET-5′-acacgatgtccactgggctcacag-3′-   24   1205   1451           TAMRA               Reverse   5′-gttgtgttcagcccagtttg-3′   20   1258   1452                  
 
     
       
         
           
               
             
               
                 TABLE AKB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag5976 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-caacttcggaaaagcagat-3′ 
                 20 
                 244 
                 1453 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ctggacatcttggaacacaccaggtc-3′- 
                 26 
                 280 
                 1454 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-ggaggacacggcatcct-3′ 
                 17 
                 311 
                 1455 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AKC 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag6345 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-aacgcacatagctcggcga-3′ 
                 19 
                 112 
                 1456 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-tgaccccacaggagcgcctgct-3′-TAMRA 
                 22 
                 147 
                 1457 
               
               
                   
               
               
                 Reverse 
                 5′-aaggttgcagctccttctccgt-3′ 
                 22 
                 229 
                 1458 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AKD 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.5 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Adipose 
                 100.0 
                 0.0 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* M14 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.0 
                 0.0 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.0 
                 0.0 
               
               
                   
                 Testis Pool 
                 0.6 
                 1.6 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 3.2 
                 3.6 
               
               
                   
                 Prostate Pool 
                 1.4 
                 1.3 
               
               
                   
                 Placenta 
                 0.0 
                 0.0 
               
               
                   
                 Uterus Pool 
                 2.8 
                 0.9 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
                 3.0 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 4.3 
                 7.9 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
                 0.0 
               
               
                   
                 Ovary 
                 0.5 
                 0.7 
               
               
                   
                 Breast ca. MCF-7 
                 0.3 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. BT 549 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. T47D 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
                 0.0 
               
               
                   
                 Breast Pool 
                 8.2 
                 6.7 
               
               
                   
                 Trachea 
                 7.3 
                 1.5 
               
               
                   
                 Lung 
                 0.3 
                 0.0 
               
               
                   
                 Fetal Lung 
                 0.4 
                 0.9 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.1 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. A549 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. NCI-H526 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. NCI-H460 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. HOP-62 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
                 0.0 
               
               
                   
                 Liver 
                 0.7 
                 0.0 
               
               
                   
                 Fetal Liver 
                 1.2 
                 1.7 
               
               
                   
                 Liver ca. HepG2 
                 2.0 
                 1.2 
               
               
                   
                 Kidney Pool 
                 15.5 
                 41.8 
               
               
                   
                 Fetal Kidney 
                 0.1 
                 0.0 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.3 
                 0.0 
               
               
                   
                 Bladder 
                 3.4 
                 0.0 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 2.2 
                 3.9 
               
               
                   
                 Gastric ca. KATO III 
                 0.1 
                 1.7 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 1.9 
                 1.4 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.3 
                 0.0 
               
               
                   
                 Colon cancer tissue 
                 15.4 
                 15.5 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
                 0.0 
               
               
                   
                 Colon Pool 
                 9.4 
                 7.0 
               
               
                   
                 Small Intestine Pool 
                 4.8 
                 1.4 
               
               
                   
                 Stomach Pool 
                 6.1 
                 6.0 
               
               
                   
                 Bone Marrow Pool 
                 3.8 
                 2.6 
               
               
                   
                 Fetal Heart 
                 0.2 
                 0.0 
               
               
                   
                 Heart Pool 
                 12.2 
                 5.0 
               
               
                   
                 Lymph Node Pool 
                 10.4 
                 13.9 
               
               
                   
                 Fetal Skeletal Muscle 
                 2.0 
                 0.0 
               
               
                   
                 Skeletal Muscle Pool 
                 54.7 
                 100.0 
               
               
                   
                 Spleen Pool 
                 0.0 
                 0.0 
               
               
                   
                 Thymus Pool 
                 6.2 
                 5.5 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.0 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 0.0 
                 0.0 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.0 
                 0.3 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 0.0 
                 0.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.0 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.5 
                 0.0 
               
               
                   
                 Brain (Amygdala) Pool 
                 0.5 
                 2.7 
               
               
                   
                 Brain (cerebellum) 
                 0.4 
                 0.0 
               
               
                   
                 Brain (fetal) 
                 0.3 
                 0.0 
               
               
                   
                 Brain (Hippocampus) Pool 
                 0.0 
                 2.4 
               
               
                   
                 Cerebral Cortex Pool 
                 1.0 
                 1.1 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 0.6 
                 0.9 
               
               
                   
                 Brain (Thalamus) Pool 
                 0.9 
                 0.0 
               
               
                   
                 Brain (whole) 
                 0.4 
                 0.0 
               
               
                   
                 Spinal Cord Pool 
                 2.5 
                 2.9 
               
               
                   
                 Adrenal Gland 
                 4.2 
                 1.6 
               
               
                   
                 Pituitary gland Pool 
                 0.4 
                 0.0 
               
               
                   
                 Salivary Gland 
                 3.0 
                 3.1 
               
               
                   
                 Thyroid (female) 
                 0.6 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 1.6 
                 0.6 
               
               
                   
                 Pancreas Pool 
                 8.5 
                 18.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag5976, Run 248204740    
               
               
                   
                   Column B - Rel. Exp. (%) Ag6345, Run 259476291    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AKE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 41.8 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 4.3 
               
               
                   
                 CC Margin (ODO3866) 
                 6.9 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 1.1 
               
               
                   
                 CC Margin (ODO3868) 
                 4.5 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 0.0 
               
               
                   
                 CC Margin (ODO3920) 
                 0.0 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 0.4 
               
               
                   
                 CC Margin (ODO3921) 
                 2.5 
               
               
                   
                 CC from Partial Hepatectomy (ODO4309) Mets 
                 0.2 
               
               
                   
                 Liver Margin (ODO4309) 
                 1.8 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 0.1 
               
               
                   
                 Lung Margin (OD04451-02) 
                 0.1 
               
               
                   
                 Normal Prostate 6546-1 
                 0.9 
               
               
                   
                 Prostate Cancer (OD04410) 
                 1.2 
               
               
                   
                 Prostate Margin (OD04410) 
                 3.2 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 0.8 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 1.9 
               
               
                   
                 Normal Lung 061010 
                 1.4 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 0.5 
               
               
                   
                 Muscle Margin (ODO4286) 
                 16.4 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 0.1 
               
               
                   
                 Lung Margin (OD03126) 
                 0.4 
               
               
                   
                 Lung Cancer (OD04404) 
                 0.3 
               
               
                   
                 Lung Margin (OD04404) 
                 0.3 
               
               
                   
                 Lung Cancer (OD04565) 
                 0.0 
               
               
                   
                 Lung Margin (OD04565) 
                 0.2 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 0.0 
               
               
                   
                 Lung Margin (OD04237-02) 
                 0.1 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 0.4 
               
               
                   
                 Liver Margin (ODO4310) 
                 2.6 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.0 
               
               
                   
                 Lung Margin (OD04321) 
                 0.2 
               
               
                   
                 Normal Kidney 
                 3.1 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04338) 
                 0.0 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 0.2 
               
               
                   
                 Kidney Margin (OD04339) 
                 1.1 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 0.3 
               
               
                   
                 Kidney Margin (OD04340) 
                 1.8 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04348) 
                 1.3 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 0.0 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.1 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 1.2 
               
               
                   
                 Kidney Cancer 8120607 
                 0.10 
               
               
                   
                 Kidney Margin 8120608 
                 0.2 
               
               
                   
                 Kidney Cancer 8120613 
                 0.7 
               
               
                   
                 Kidney Margin 8120614 
                 2.0 
               
               
                   
                 Kidney Cancer 9010320 
                 8.4 
               
               
                   
                 Kidney Margin 9010321 
                 2.0 
               
               
                   
                 Normal Uterus 
                 2.4 
               
               
                   
                 Uterus Cancer 064011 
                 4.4 
               
               
                   
                 Normal Thyroid 
                 2.3 
               
               
                   
                 Thyroid Cancer 064010 
                 0.0 
               
               
                   
                 Thyroid Cancer A302152 
                 0.4 
               
               
                   
                 Thyroid Margin A302153 
                 0.5 
               
               
                   
                 Normal Breast 
                 80.7 
               
               
                   
                 Breast Cancer (OD04566) 
                 1.5 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 21.0 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 100.0 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 13.3 
               
               
                   
                 Breast Cancer 064006 
                 0.9 
               
               
                   
                 Breast Cancer 1024 
                 5.8 
               
               
                   
                 Breast Cancer 9100266 
                 3.2 
               
               
                   
                 Breast Margin 9100265 
                 5.9 
               
               
                   
                 Breast Cancer A209073 
                 2.0 
               
               
                   
                 Breast Margin A209073 
                 7.9 
               
               
                   
                 Normal Liver 
                 3.3 
               
               
                   
                 Liver Cancer 064003 
                 2.2 
               
               
                   
                 Liver Cancer 1025 
                 6.0 
               
               
                   
                 Liver Cancer 1026 
                 2.0 
               
               
                   
                 Liver Cancer 6004-T 
                 7.5 
               
               
                   
                 Liver Tissue 6004-N 
                 2.2 
               
               
                   
                 Liver Cancer 6005-T 
                 1.8 
               
               
                   
                 Liver Tissue 6005-N 
                 0.3 
               
               
                   
                 Normal Bladder 
                 6.0 
               
               
                   
                 Bladder Cancer 1023 
                 0.7 
               
               
                   
                 Bladder Cancer A302173 
                 0.4 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 0.1 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 11.7 
               
               
                   
                 Normal Ovary 
                 0.8 
               
               
                   
                 Ovarian Cancer 064008 
                 1.1 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 0.7 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 2.9 
               
               
                   
                 Normal Stomach 
                 15.1 
               
               
                   
                 Gastric Cancer 9060358 
                 6.4 
               
               
                   
                 Stomach Margin 9060359 
                 2.0 
               
               
                   
                 Gastric Cancer 9060395 
                 8.8 
               
               
                   
                 Stomach Margin 9060394 
                 8.4 
               
               
                   
                 Gastric Cancer 9060397 
                 0.9 
               
               
                   
                 Stomach Margin 9060396 
                 3.1 
               
               
                   
                 Gastric Cancer 064005 
                 5.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2840, Run 161922469    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AKF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D 
               
            
           
           
               
               
            
               
                 Tissue Name 
                 A 
               
               
                   
               
            
           
           
               
               
            
               
                 Daoy- Medulloblastoma 
                 22.1 
               
               
                 TE671- Medulloblastoma 
                 10.1 
               
               
                 D283 Med- Medulloblastoma 
                 2.3 
               
               
                 PFSK-1- Primitive Neuroectodermal 
                 6.2 
               
               
                 XF-498- CNS 
                 8.4 
               
               
                 SNB-78- Glioma 
                 5.0 
               
               
                 SF-268- Glioblastoma 
                 1.4 
               
               
                 T98G- Glioblastoma 
                 0.0 
               
               
                 SK-N-SH- Neuroblastoma (metastasis) 
                 2.7 
               
               
                 SF-295- Glioblastoma 
                 2.9 
               
               
                 Cerebellum 
                 3.4 
               
               
                 Cerebellum 
                 38.2 
               
               
                 NCI-H292- Mucoepidermoid lung carcinoma 
                 0.0 
               
               
                 DMS-114- Small cell lung cancer 
                 0.0 
               
               
                 DMS-79- Small cell lung cancer 
                 100.0 
               
               
                 NCI-H146- Small cell lung cancer 
                 0.0 
               
               
                 NCI-H526- Small cell lung cancer 
                 9.6 
               
               
                 NCI-N417- Small cell lung cancer 
                 0.0 
               
               
                 NCI-H82- Small cell lung cancer 
                 3.3 
               
               
                 NCI-H157- Squamous cell lung cancer (metastasis) 
                 0.0 
               
               
                 NCI-H1155- Large cell lung cancer 
                 20.6 
               
               
                 NCI-H1299- Large cell lung cancer 
                 9.2 
               
               
                 NCI-H727- Lung carcinoid 
                 0.0 
               
               
                 NCI-UMC-11- Lung carcinoid 
                 0.0 
               
               
                 LX-1- Small cell lung cancer 
                 7.9 
               
               
                 Colo-205- Colon cancer 
                 0.0 
               
               
                 KM12- Colon cancer 
                 0.0 
               
               
                 KM20L2- Colon cancer 
                 2.9 
               
               
                 NCI-H716- Colon cancer 
                 0.0 
               
               
                 SW-48- Colon adenocarcinoma 
                 0.0 
               
               
                 SW1116- Colon adenocarcinoma 
                 0.0 
               
               
                 LS 174T- Colon adenocarcinoma 
                 0.0 
               
               
                 SW-948- Colon adenocarcinoma 
                 0.0 
               
               
                 SW-480- Colon adenocarcinoma 
                 3.8 
               
               
                 NCI-SNU-5- Gastric carcinoma 
                 2.1 
               
               
                 KATO III- Gastric carcinoma 
                 12.0 
               
               
                 NCI-SNU-16- Gastric carcinoma 
                 5.8 
               
               
                 NCI-SNU-1- Gastric carcinoma 
                 2.6 
               
               
                 RF-1- Gastric adenocarcinoma 
                 0.0 
               
               
                 RF-48- Gastric adenocarcinoma 
                 7.2 
               
               
                 MKN-45- Gastric carcinoma 
                 96.6 
               
               
                 NCI-N87- Gastric carcinoma 
                 10.0 
               
               
                 OVCAR-5- Ovarian carcinoma 
                 3.7 
               
               
                 RL95-2- Uterine carcinoma 
                 7.2 
               
               
                 HelaS3- Cervical adenocarcinoma 
                 0.0 
               
               
                 Ca Ski- Cervical epidermoid carcinoma (metastasis) 
                 7.6 
               
               
                 ES-2- Ovarian clear cell carcinoma 
                 0.0 
               
               
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 0.0 
               
               
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 0.0 
               
               
                 MEG-01- Chronic myelogenous leukemia (megokaryoblast) 
                 0.0 
               
               
                 Raji- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                 Daudi- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                 U266- B-cell plasmacytoma 
                 10.4 
               
               
                 CA46- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 5.9 
               
               
                 JM1- pre-B-cell lymphoma 
                 7.8 
               
               
                 Jurkat- T cell leukemia 
                 2.7 
               
               
                 TF-1- Erythroleukemia 
                 5.0 
               
               
                 HUT 78- T-cell lymphoma 
                 0.0 
               
               
                 U937- Histiocytic lymphoma 
                 11.0 
               
               
                 KU-812- Myelogenous leukemia 
                 31.0 
               
               
                 769-P- Clear cell renal carcinoma 
                 6.1 
               
               
                 Caki-2- Clear cell renal carcinoma 
                 3.0 
               
               
                 SW 839- Clear cell renal carcinoma 
                 0.0 
               
               
                 Rhabdoid kidney tumor 
                 3.7 
               
               
                 Hs766T- Pancreatic carcinoma (LN metastasis) 
                 9.8 
               
               
                 CAPAN-1- Pancreatic adenocarcinoma (liver metastasis) 
                 0.0 
               
               
                 SU86.86- Pancreatic carcinoma (liver metastasis) 
                 5.0 
               
               
                 BxPC-3- Pancreatic adenocarcinoma 
                 13.0 
               
               
                 HPAC- Pancreatic adenocarcinoma 
                 20.7 
               
               
                 MIA PaCa-2- Pancreatic carcinoma 
                 4.2 
               
               
                 CFPAC-1- Pancreatic ductal adenocarcinoma 
                 13.9 
               
               
                 PANC-1- Pancreatic epithelioid ductal carcinoma 
                 69.7 
               
               
                 T24- Bladder carcinma (transitional cell) 
                 0.0 
               
               
                 5637- Bladder carcinoma 
                 0.0 
               
               
                 HT-1197- Bladder carcinoma 
                 6.4 
               
               
                 UM-UC-3- Bladder carcinma (transitional cell) 
                 2.4 
               
               
                 A204- Rhabdomyosarcoma 
                 12.5 
               
               
                 HT-1080- Fibrosarcoma 
                 12.1 
               
               
                 MG-63- Osteosarcoma 
                 0.0 
               
               
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 16.7 
               
               
                 SJRH30- Rhabdomyosarcoma (met to bone marrow) 
                 5.7 
               
               
                 A431- Epidermoid carcinoma 
                 0.0 
               
               
                 WM266-4- Melanoma 
                 0.0 
               
               
                 DU 145- Prostate carcinoma (brain metastasis) 
                 0.0 
               
               
                 MDA-MB-468- Breast adenocarcinoma 
                 11.4 
               
               
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                 SCC-9- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                 CAL 27- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag2840, Run 170190088    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AKG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Secondary Th1 act 
                 6.4 
                 0.0 
               
               
                 Secondary Th2 act 
                 2.0 
                 0.0 
               
               
                 Secondary Tr1 act 
                 4.0 
                 0.0 
               
               
                 Secondary Th1 rest 
                 4.4 
                 0.0 
               
               
                 Secondary Th2 rest 
                 13.9 
                 0.0 
               
               
                 Secondary Tr1 rest 
                 8.2 
                 0.0 
               
               
                 Primary Th1 act 
                 3.0 
                 0.0 
               
               
                 Primary Th2 act 
                 9.6 
                 0.0 
               
               
                 Primary Tr1 act 
                 1.6 
                 0.0 
               
               
                 Primary Th1 rest 
                 3.2 
                 0.0 
               
               
                 Primary Th2 rest 
                 5.6 
                 0.0 
               
               
                 Primary Tr1 rest 
                 6.4 
                 0.0 
               
               
                 CD45RA CD4 lymphocyte act 
                 6.0 
                 0.0 
               
               
                 CD45RO CD4 lymphocyte act 
                 6.2 
                 0.0 
               
               
                 CD8 lymphocyte act 
                 6.4 
                 0.0 
               
               
                 Secondary CD8 lymphocyte rest 
                 2.4 
                 0.0 
               
               
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD4 lymphocyte none 
                 12.5 
                 0.0 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 11.3 
                 0.0 
               
               
                 LAK cells rest 
                 7.6 
                 0.0 
               
               
                 LAK cells IL-2 
                 4.2 
                 0.0 
               
               
                 LAK cells IL-2 + IL-12 
                 1.9 
                 0.0 
               
               
                 LAK cells IL-2 + IFN gamma 
                 2.7 
                 0.0 
               
               
                 LAK cells IL-2 + IL-18 
                 6.6 
                 0.0 
               
               
                 LAK cells PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                 NK Cells IL-2 rest 
                 3.4 
                 0.0 
               
               
                 Two Way MLR 3 day 
                 6.7 
                 0.0 
               
               
                 Two Way MLR 5 day 
                 5.8 
                 0.0 
               
               
                 Two Way MLR 7 day 
                 8.5 
                 0.0 
               
               
                 PBMC rest 
                 9.3 
                 0.0 
               
               
                 PBMC PWM 
                 1.0 
                 0.0 
               
               
                 PBMC PHA-L 
                 3.2 
                 0.0 
               
               
                 Ramos (B cell) none 
                 1.9 
                 0.0 
               
               
                 Ramos (B cell) ionomycin 
                 3.0 
                 0.0 
               
               
                 B lymphocytes PWM 
                 1.0 
                 0.0 
               
               
                 B lymphocytes CD40L and IL-4 
                 9.4 
                 0.0 
               
               
                 EOL-1 dbcAMP 
                 0.8 
                 0.0 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 6.0 
                 0.0 
               
               
                 Dendritic cells none 
                 0.9 
                 0.0 
               
               
                 Dendritic cells LPS 
                 0.0 
                 0.0 
               
               
                 Dendritic cells anti-CD40 
                 3.1 
                 0.0 
               
               
                 Monocytes rest 
                 13.8 
                 0.0 
               
               
                 Monocytes LPS 
                 4.9 
                 0.0 
               
               
                 Macrophages rest 
                 2.1 
                 0.0 
               
               
                 Macrophages LPS 
                 0.9 
                 0.0 
               
               
                 HUVEC none 
                 6.3 
                 0.0 
               
               
                 HUVEC starved 
                 7.9 
                 0.0 
               
               
                 HUVEC IL-1beta 
                 0.9 
                 0.0 
               
               
                 HUVEC IFN gamma 
                 4.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IL4 
                 5.4 
                 0.0 
               
               
                 HUVEC IL-11 
                 3.8 
                 0.0 
               
               
                 Lung Microvascular EC none 
                 8.4 
                 0.0 
               
               
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 4.0 
                 0.0 
               
               
                 Microvascular Dermal EC none 
                 4.5 
                 0.0 
               
               
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Bronchial epithelium TNFalpha + IL1beta 
                 10.4 
                 0.0 
               
               
                 Small airway epithelium none 
                 5.9 
                 0.0 
               
               
                 Small airway epithelium TNFalpha + IL-1beta 
                 8.5 
                 0.0 
               
               
                 Coronery artery SMC rest 
                 0.0 
                 0.0 
               
               
                 Coronery artery SMC TNFalpha + IL-1beta 
                 1.0 
                 0.0 
               
               
                 Astrocytes rest 
                 0.0 
                 0.0 
               
               
                 Astrocytes TNFalpha + IL-1beta 
                 1.4 
                 0.0 
               
               
                 KU-812 (Basophil) rest 
                 8.4 
                 20.0 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 6.1 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) none 
                 6.7 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 1.8 
                 0.0 
               
               
                 Liver cirrhosis 
                 63.3 
                 0.0 
               
               
                 NCI-H292 none 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IL-4 
                 0.0 
                 56.3 
               
               
                 NCI-H292 IL-9 
                 0.0 
                 65.5 
               
               
                 NCI-H292 IL-13 
                 0.0 
                 48.6 
               
               
                 NCI-H292 IFN gamma 
                 0.0 
                 24.3 
               
               
                 HPAEC none 
                 0.0 
                 0.0 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 3.3 
                 0.0 
               
               
                 Lung fibroblast none 
                 29.5 
                 100.0 
               
               
                 Lung fibroblast TNF alpha + IL-1 beta 
                 8.2 
                 0.0 
               
               
                 Lung fibroblast IL-4 
                 7.9 
                 0.0 
               
               
                 Lung fibroblast IL-9 
                 10.3 
                 0.0 
               
               
                 Lung fibroblast IL-13 
                 4.2 
                 0.0 
               
               
                 Lung fibroblast IFN gamma 
                 9.1 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 rest 
                 2.3 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 9.2 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 4.9 
                 0.0 
               
               
                 Dermal fibroblast IFN gamma 
                 1.0 
                 0.0 
               
               
                 Dermal fibroblast IL-4 
                 8.1 
                 0.0 
               
               
                 Dermal Fibroblasts rest 
                 4.2 
                 0.0 
               
               
                 Neutrophils TNFa + LPS 
                 25.0 
                 0.0 
               
               
                 Neutrophils rest 
                 66.9 
                 18.7 
               
               
                 Colon 
                 100.0 
                 54.7 
               
               
                 Lung 
                 3.8 
                 0.0 
               
               
                 Thymus 
                 24.5 
                 46.7 
               
               
                 Kidney 
                 32.1 
                 0.0 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag2840, Run 204964146    
               
               
                   Column B - Rel. Exp. (%) Ag5976, Run 248122612    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AKH 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 5D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 97457_Patient-02go_adipose 
                 63.3 
               
               
                   
                 97476_Patient-07sk_skeletal muscle 
                 15.8 
               
               
                   
                 97477_Patient-07ut_uterus 
                 8.8 
               
               
                   
                 97478_Patient-07pl_placenta 
                 0.0 
               
               
                   
                 97481_Patient-08sk_skeletal muscle 
                 15.7 
               
               
                   
                 97482_Patient-08ut_uterus 
                 8.4 
               
               
                   
                 97483_Patient-08pl_placenta 
                 0.0 
               
               
                   
                 97486_Patient-09sk_skeletal muscle 
                 1.4 
               
               
                   
                 97487_Patient-09ut_uterus 
                 5.5 
               
               
                   
                 97488_Patient-09pl_placenta 
                 0.0 
               
               
                   
                 97492_Patient-10ut_uterus 
                 4.6 
               
               
                   
                 97493_Patient-10pl_placenta 
                 0.3 
               
               
                   
                 97495_Patient-11go_adipose 
                 0.0 
               
               
                   
                 97496_Patient-11sk_skeletal muscle 
                 0.0 
               
               
                   
                 97497_Patient-11ut_uterus 
                 0.0 
               
               
                   
                 97498_Patient-11pl_placenta 
                 0.0 
               
               
                   
                 97500_Patient-12go_adipose 
                 48.0 
               
               
                   
                 97501_Patient-12sk_skeletal muscle 
                 100.0 
               
               
                   
                 97502_Patient-12ut_uterus 
                 18.7 
               
               
                   
                 97503_Patient-12pl_placenta 
                 0.0 
               
               
                   
                 94721_Donor 2 U - A_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94722_Donor 2 U - B_Mesenchymal Stem Cells 
                 0.2 
               
               
                   
                 94723_Donor 2 U - C_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94709_Donor 2 AM - A_adipose 
                 24.1 
               
               
                   
                 94710_Donor 2 AM - B_adipose 
                 7.9 
               
               
                   
                 94711_Donor 2 AM - C_adipose 
                 4.5 
               
               
                   
                 94712_Donor 2 AD - A_adipose 
                 18.3 
               
               
                   
                 94713_Donor 2 AD - B_adipose 
                 24.1 
               
               
                   
                 94714_Donor 2 AD - C_adipose 
                 23.5 
               
               
                   
                 94742_Donor 3 U - A_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94743_Donor 3 U - B_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94730_Donor 3 AM - A_adipose 
                 0.0 
               
               
                   
                 94731_Donor 3 AM - B_adipose 
                 0.0 
               
               
                   
                 94732_Donor 3 AM - C_adipose 
                 0.1 
               
               
                   
                 94733_Donor 3 AD - A_adipose 
                 0.0 
               
               
                   
                 94734_Donor 3 AD - B_adipose 
                 0.0 
               
               
                   
                 94735_Donor 3 AD - C_adipose 
                 0.0 
               
               
                   
                 77138_Liver_HepG2untreated 
                 1.1 
               
               
                   
                 73556_Heart_Cardiac stromal cells (primary) 
                 0.0 
               
               
                   
                 81735_Small Intestine 
                 16.8 
               
               
                   
                 72409_Kidney_Proximal Convoluted Tubule 
                 0.0 
               
               
                   
                 82685_Small intestine_Duodenum 
                 0.7 
               
               
                   
                 90650_Adrenal_Adrenocortical adenoma 
                 0.1 
               
               
                   
                 72410_Kidney_HRCE 
                 0.0 
               
               
                   
                 72411_Kidney_HRE 
                 0.0 
               
               
                   
                 73139_Uterus_Uterine smooth muscle cells 
                 0.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2840, Run 169270970    
               
            
           
         
       
     
      General_screening_panel_v1.5 Summary: Ag5976 Highest expression of this gene was detected in adipose (CT=29). Moderate levels of expression of this gene was also seen in skeletal muscle, colon, small intestine, adrenal gland and heart. This gene codes for a homolog of mouse S3-12 protein. S3-12 is an adipose cell membrane-associated protein upregulated during adipocyte differentiation. Due to its weak homology with adipophilins, it is involved in lipid uptake. Inhibiting its action by an antibody will reduce potential white adipose mass by limiting lipid uptake and thereby inhibit adipocyte differentiation. Its expression in skeletal muscle indicates that it functions similarly in muscle tissue as well, in terms of lipid uptake. Since excess lipid storage in muscle is associated with insulin resistance, antibody inhibition of this gene product is useful as a treatment for the prevention of obesity-associated insulin resistance.  
      Furthermore, modulation of this gene or expressed protein is useful for the treatment of metabolic disease, including Types 1 and 2 diabetes, and obesity.  
      Low expression of this gene was also seen in colon cancer tissue and cancer cell lines derived from ovarian and prostate cancers.  
      Low levels of expression in the spinal cord show that the protein encoded by this gene plays a role in lipid processing in the central nervous system. Modulation of this gene or gene product is useful in the treatment of spinal cord related disorders.  
      Ag6345 Highest expression of this gene was detected in adipose and skeletal muscle (CTs=31). Significant expression of this gene was also seen in pancreas, and kidney.  
      Panel 2D Summary: Ag2840 This gene was moderately expressed in all tissue samples this panel, with highest expression in metastatic breast cancer (CT=24.5). This gene showed higher expression in normal kidney, prostate, colon and bladder samples relative to the corresponding adjacent tumor sample. Expression of this gene is useful to differentiate between normal and cancerous tissues. Therapeutic modulation of this gene, expressed protein and/or use of agonists targeting this gene or gene product is useful in the treatment of kidney, prostate, colon and bladder cancers.  
      Panel 3D Summary: Ag2840 This gene showed low levels of expression in the cancer cell lines, with highest expression in the gastric cancer MKN-45 cell line (CT=32). Significant expression was seen in cancer cell lines derived from lung cancer, pancreatic cancer and a leukemia. Therapeutic modulation of this gene, expressed protein and/or use of antibodies or small molecule drug targeting this gene or gene product is useful in the treatment of these cancers.  
      Panel 4.1D Summary: Ag2840 This transcript was expressed in colon and in resting neutrophils (CTs=31-33). The transcript or the protein it encodes are isefi; as markers to detect colon tissue and neutrophils. Therapeutics modulation of this gene, expressed protein and/or use of antibodies or small molecule targeting this gene or gene product is useful in the treatment of autoimmune and inflammatory diseases such as asthma, allergies, inflammatory bowel disease including Crohn&#39;s and Colitis, lupus erythematosus, psoriasis, rheumatoid arthritis, and osteoarthritis.  
      Panel 5D Summary: Ag2840 This gene was moderately expressed in clinical specimens of adipose, skeletal muscle and uterus. This confirms expression of this gene in tissues with metabolic function. Please see Panel 1.5D for discussion of utility of this gene in metabolic disease.  
      AL. CG5590801: Integrin A and FG GAP Domain Protein  
      Expression of full-length physical clone CG55908-01 was assessed using the primer-probe sets Ag6400, Ag6446, Ag6449 and Ag6964, described in Tables ALA, ALB, ALC and ALD. Results of the RTQ-PCR runs are shown in Table ALE.  
               TABLE ALA                          Probe Name Ag6400                                                 Start   SEQ ID           Primers   Sequences   Length   Position   No                                             Forward   5′-gagctgatatgcaaaaggaaag-3′   22   300   1459                   Probe   TET-5′-ctgactcccaaccactggttctcctt-3′-   26   323   1460           TAMRA               Reverse   5′-gggcgcagtcaacaatct-3′   18   375   1461                  
 
     
       
         
           
               
             
               
                 TABLE ALB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag6446 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-gcttcttccatcggagca-3′ 
                 18 
                 726 
                 1462 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-caactatcaccgggcctgtctggc-3′- 
                 24 
                 766 
                 1463 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-catggctgaaggctgca-3′ 
                 17 
                 792 
                 1464 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ALC 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag6449 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-gagtcagtgttcggagcca-3′ 
                 19 
                 342 
                 1465 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ctgcccactctacagctttgaccgc-3′- 
                 25 
                 421 
                 1466 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-cccagacatgcagcacag-3′ 
                 18 
                 450 
                 1467 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ALD 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag6964 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 Start 
                 SEQ ID 
                   
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-ggccccagacatgca-3′ 
                 15 
                 456 
                 1468 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-actctacagctttgacccgcgcgg-3′-TAMRA 
                 23 
                 427 
                 1469 
               
               
                   
               
               
                 Reverse 
                 5′-gccaactgtgtggtgttca-3′ 
                 19 
                 401 
                 1470 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ALE 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.6 
               
            
           
           
               
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
                 D 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Adipose 
                 0.0 
                 1.7 
                 0.0 
                 18.8 
               
               
                 Melanoma* Hs688(A).T 
                 0.0 
                 0.1 
                 0.0 
                 0.7 
               
               
                 Melanoma* Hs688(B).T 
                 0.0 
                 0.1 
                 0.0 
                 2.4 
               
               
                 Melanoma* M14 
                 0.0 
                 0.1 
                 0.0 
                 0.7 
               
               
                 Melanoma* LOXIMVI 
                 0.0 
                 0.1 
                 0.0 
                 0.1 
               
               
                 Melanoma* SK-MEL-5 
                 0.0 
                 6.8 
                 0.0 
                 15.9 
               
               
                 Squamous cell carcinoma SCC-4 
                 0.0 
                 0.0 
                 0.0 
                 0.1 
               
               
                 Testis Pool 
                 0.0 
                 5.8 
                 0.0 
                 9.9 
               
               
                 Prostate ca.* (bone met) PC-3 
                 0.0 
                 7.7 
                 0.0 
                 4.3 
               
               
                 Prostate Pool 
                 0.0 
                 1.9 
                 0.0 
                 10.0 
               
               
                 Placenta 
                 0.0 
                 0.9 
                 0.0 
                 0.4 
               
               
                 Uterus Pool 
                 0.0 
                 0.3 
                 0.0 
                 4.1 
               
               
                 Ovarian ca. OVCAR-3 
                 0.0 
                 4.8 
                 0.0 
                 4.0 
               
               
                 Ovarian ca. SK-OV-3 
                 0.0 
                 2.5 
                 0.0 
                 1.7 
               
               
                 Ovarian ca. OVCAR-4 
                 0.0 
                 0.5 
                 0.0 
                 0.5 
               
               
                 Ovarian ca. OVCAR-5 
                 0.0 
                 15.6 
                 0.0 
                 7.9 
               
               
                 Ovarian ca. IGROV-1 
                 22.2 
                 5.4 
                 79.0 
                 75.8 
               
               
                 Ovarian ca. OVCAR-8 
                 0.0 
                 4.2 
                 0.0 
                 16.7 
               
               
                 Ovary 
                 0.0 
                 0.2 
                 0.0 
                 2.4 
               
               
                 Breast ca. MCF-7 
                 0.0 
                 0.9 
                 0.0 
                 0.5 
               
               
                 Breast ca. MDA-MB-231 
                 0.0 
                 0.2 
                 0.0 
                 0.3 
               
               
                 Breast ca. BT 549 
                 0.0 
                 0.2 
                 0.0 
                 0.4 
               
               
                 Breast ca. T47D 
                 0.0 
                 0.7 
                 0.0 
                 0.5 
               
               
                 Breast ca. MDA-N 
                 0.0 
                 0.0 
                 10.2 
                 0.8 
               
               
                 Breast Pool 
                 0.0 
                 2.0 
                 0.0 
                 16.7 
               
               
                 Trachea 
                 0.0 
                 0.5 
                 0.0 
                 5.6 
               
               
                 Lung 
                 0.0 
                 0.5 
                 0.0 
                 5.1 
               
               
                 Fetal Lung 
                 0.0 
                 0.5 
                 0.0 
                 6.1 
               
               
                 Lung ca. NCI-N417 
                 0.0 
                 0.4 
                 0.0 
                 2.3 
               
               
                 Lung ca. LX-1 
                 0.0 
                 100.0 
                 0.0 
                 44.1 
               
               
                 Lung ca. NCI-H146 
                 0.0 
                 0.1 
                 0.0 
                 0.1 
               
               
                 Lung ca. SHP-77 
                 0.0 
                 0.1 
                 0.0 
                 3.8 
               
               
                 Lung ca. A549 
                 0.0 
                 14.3 
                 0.0 
                 4.7 
               
               
                 Lung ca. NCI-H526 
                 0.0 
                 0.0 
                 0.0 
                 0.5 
               
               
                 Lung ca. NCI-H23 
                 0.0 
                 15.9 
                 0.0 
                 10.3 
               
               
                 Lung ca. NCI-H460 
                 0.0 
                 0.1 
                 0.0 
                 0.3 
               
               
                 Lung ca. HOP-62 
                 0.0 
                 0.2 
                 0.0 
                 0.7 
               
               
                 Lung ca. NCI-H522 
                 0.0 
                 27.7 
                 0.0 
                 8.9 
               
               
                 Liver 
                 0.0 
                 5.3 
                 0.0 
                 2.0 
               
               
                 Fetal Liver 
                 0.0 
                 23.0 
                 0.0 
                 8.2 
               
               
                 Liver ca. HepG2 
                 0.0 
                 7.3 
                 0.0 
                 2.4 
               
               
                 Kidney Pool 
                 21.9 
                 5.3 
                 0.0 
                 32.8 
               
               
                 Fetal Kidney 
                 0.0 
                 20.2 
                 0.0 
                 11.5 
               
               
                 Renal ca. 786-0 
                 0.0 
                 1.7 
                 0.0 
                 0.9 
               
               
                 Renal ca. A498 
                 0.0 
                 23.0 
                 0.0 
                 8.5 
               
               
                 Renal ca. ACHN 
                 0.0 
                 3.8 
                 0.0 
                 2.5 
               
               
                 Renal ca. UO-31 
                 0.0 
                 0.7 
                 0.0 
                 0.3 
               
               
                 Renal ca. TK-10 
                 0.0 
                 6.4 
                 0.0 
                 4.6 
               
               
                 Bladder 
                 0.0 
                 3.2 
                 0.0 
                 6.7 
               
               
                 Gastric ca. (liver met.) NCI-N87 
                 0.0 
                 17.8 
                 0.0 
                 6.7 
               
               
                 Gastric ca. KATO III 
                 0.0 
                 1.3 
                 0.0 
                 0.9 
               
               
                 Colon ca. SW-948 
                 0.0 
                 6.1 
                 0.0 
                 1.2 
               
               
                 Colon ca. SW480 
                 21.6 
                 39.0 
                 0.0 
                 33.7 
               
               
                 Colon ca.* (SW480 met) SW620 
                 0.0 
                 71.2 
                 0.0 
                 25.0 
               
               
                 Colon ca. HT29 
                 0.0 
                 3.5 
                 0.0 
                 0.3 
               
               
                 Colon ca. HCT-116 
                 0.0 
                 6.4 
                 0.0 
                 4.3 
               
               
                 Colon ca. CaCo-2 
                 12.2 
                 78.5 
                 0.0 
                 38.2 
               
               
                 Colon cancer tissue 
                 0.0 
                 21.9 
                 0.0 
                 20.4 
               
               
                 Colon ca. SW1116 
                 0.0 
                 19.5 
                 0.0 
                 6.0 
               
               
                 Colon ca. Colo-205 
                 0.0 
                 3.0 
                 0.0 
                 0.8 
               
               
                 Colon ca. SW-48 
                 0.0 
                 4.2 
                 0.0 
                 2.6 
               
               
                 Colon Pool 
                 0.0 
                 3.1 
                 5.1 
                 20.6 
               
               
                 Small Intestine Pool 
                 0.0 
                 2.5 
                 0.0 
                 10.4 
               
               
                 Stomach Pool 
                 0.0 
                 1.1 
                 0.0 
                 10.7 
               
               
                 Bone Marrow Pool 
                 0.0 
                 1.1 
                 0.0 
                 12.5 
               
               
                 Fetal Heart 
                 0.0 
                 2.7 
                 0.0 
                 20.7 
               
               
                 Heart Pool 
                 0.0 
                 3.4 
                 0.0 
                 26.1 
               
               
                 Lymph Node Pool 
                 0.0 
                 2.8 
                 0.0 
                 24.7 
               
               
                 Fetal Skeletal Muscle 
                 0.0 
                 57.0 
                 0.0 
                 50.7 
               
               
                 Skeletal Muscle Pool 
                 0.0 
                 24.3 
                 0.0 
                 32.3 
               
               
                 Spleen Pool 
                 0.0 
                 2.6 
                 0.0 
                 3.1 
               
               
                 Thymus Pool 
                 0.0 
                 1.4 
                 0.0 
                 7.0 
               
               
                 CNS cancer (glio/astro) U87-MG 
                 0.0 
                 6.3 
                 0.0 
                 14.1 
               
               
                 CNS cancer (glio/astro) U-118-MG 
                 0.0 
                 5.1 
                 0.0 
                 5.8 
               
               
                 CNS cancer (neuro; met) SK-N-AS 
                 0.0 
                 3.9 
                 0.0 
                 2.6 
               
               
                 CNS cancer (astro) SF-539 
                 0.0 
                 0.3 
                 0.0 
                 0.1 
               
               
                 CNS cancer (astro) SNB-75 
                 0.0 
                 2.4 
                 0.0 
                 9.7 
               
               
                 CNS cancer (glio) SNB-19 
                 0.0 
                 5.2 
                 100.0 
                 100.0 
               
               
                 CNS cancer (glio) SF-295 
                 0.0 
                 14.9 
                 0.0 
                 14.8 
               
               
                 Brain (Amygdala) Pool 
                 0.0 
                 1.1 
                 0.0 
                 5.3 
               
               
                 Brain (cerebellum) 
                 0.0 
                 1.4 
                 0.0 
                 9.7 
               
               
                 Brain (fetal) 
                 0.0 
                 1.1 
                 0.0 
                 6.4 
               
               
                 Brain (Hippocampus) Pool 
                 0.0 
                 2.0 
                 0.0 
                 10.2 
               
               
                 Cerebral Cortex Pool 
                 0.0 
                 2.0 
                 0.0 
                 8.7 
               
               
                 Brain (Substantia nigra) Pool 
                 0.0 
                 1.1 
                 0.0 
                 9.3 
               
               
                 Brain (Thalamus) Pool 
                 0.0 
                 3.2 
                 0.0 
                 8.7 
               
               
                 Brain (whole) 
                 0.0 
                 1.9 
                 0.0 
                 8.7 
               
               
                 Spinal Cord Pool 
                 100.0 
                 2.9 
                 0.0 
                 9.0 
               
               
                 Adrenal Gland 
                 0.0 
                 0.7 
                 0.0 
                 4.1 
               
               
                 Pituitary gland Pool 
                 0.0 
                 0.4 
                 0.0 
                 0.5 
               
               
                 Salivary Gland 
                 0.0 
                 0.2 
                 0.0 
                 1.0 
               
               
                 Thyroid (female) 
                 0.0 
                 0.8 
                 0.0 
                 2.3 
               
               
                 Pancreatic ca. CAPAN2 
                 0.0 
                 4.6 
                 0.0 
                 2.2 
               
               
                 Pancreas Pool 
                 0.0 
                 2.6 
                 0.0 
                 2.3 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag6400, Run 277248363    
               
               
                   Column B - Rel. Exp. (%) Ag6446, Run 277250179    
               
               
                   Column C - Rel. Exp. (%) Ag6449, Run 277250185    
               
               
                   Column D - Rel. Exp. (%) Ag6964, Run 278388946    
               
            
           
         
       
     
      General_screening_panel_v1.6 Summary: Highest expression of this gene was detected in an ovarian cancer IGROV-1 cell line and a brain cancer SNB-19 cell line (CTs=25-33.7). Moderate to low levels of expression of this gene are also seen in all the regions of central nervous system, tissues with metabolic/endocrine functions, and number of cancer cell lines.  
      AM. CG56110-03: B7 H1  
      Expression of full-length physical clone CG56110-03 was assessed using the primer-probe set Ag1544, described in Table AMA. Results of the RTQ-PCR runs are shown in Tables AMB, AMC and AMD.  
               TABLE AMA                          Probe Name Ag1544                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No                                             Forward   5′-tctggacaagcagtgaccat-3′   20   497   1471                   Probe   TET-5′-accaccaccaattccaagagagagga-3′-   26   538   1472           TAMRA               Reverse   5′-ttctcagtgtgctggtcaca-3′   120   576   1473                  
 
     
       
         
           
               
             
               
                 TABLE AMB 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 3.6 
               
               
                   
                 Pancreas 
                 2.9 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 5.0 
               
               
                   
                 Adrenal gland 
                 2.4 
               
               
                   
                 Thyroid 
                 2.3 
               
               
                   
                 Salivary gland 
                 1.7 
               
               
                   
                 Pituitary gland 
                 6.3 
               
               
                   
                 Brain (fetal) 
                 1.8 
               
               
                   
                 Brain (whole) 
                 3.5 
               
               
                   
                 Brain (amygdala) 
                 2.8 
               
               
                   
                 Brain (cerebellum) 
                 1.7 
               
               
                   
                 Brain (hippocampus) 
                 4.5 
               
               
                   
                 Brain (substantia nigra) 
                 2.7 
               
               
                   
                 Brain (thalamus) 
                 4.4 
               
               
                   
                 Cerebral Cortex 
                 10.4 
               
               
                   
                 Spinal cord 
                 2.0 
               
               
                   
                 glio/astro U87-MG 
                 25.5 
               
               
                   
                 glio/astro U-118-MG 
                 8.2 
               
               
                   
                 astrocytoma SW1783 
                 7.9 
               
               
                   
                 neuro*; met SK-N-AS 
                 9.2 
               
               
                   
                 astrocytoma SF-539 
                 6.3 
               
               
                   
                 astrocytoma SNB-75 
                 37.9 
               
               
                   
                 glioma SNB-19 
                 12.3 
               
               
                   
                 glioma U251 
                 14.7 
               
               
                   
                 glioma SF-295 
                 6.0 
               
               
                   
                 Heart (fetal) 
                 9.0 
               
               
                   
                 Heart 
                 5.4 
               
               
                   
                 Skeletal muscle (fetal) 
                 6.2 
               
               
                   
                 Skeletal muscle 
                 1.9 
               
               
                   
                 Bone marrow 
                 3.2 
               
               
                   
                 Thymus 
                 13.4 
               
               
                   
                 Spleen 
                 14.0 
               
               
                   
                 Lymph node 
                 27.0 
               
               
                   
                 Colorectal 
                 1.5 
               
               
                   
                 Stomach 
                 3.4 
               
               
                   
                 Small intestine 
                 2.7 
               
               
                   
                 Colon ca. SW480 
                 2.2 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 0.8 
               
               
                   
                 Colon ca. HT29 
                 1.6 
               
               
                   
                 Colon ca. HCT-116 
                 2.6 
               
               
                   
                 Colon ca. CaCo-2 
                 0.6 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 6.6 
               
               
                   
                 Colon ca. HCC-2998 
                 4.5 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 100.0 
               
               
                   
                 Bladder 
                 6.7 
               
               
                   
                 Trachea 
                 10.9 
               
               
                   
                 Kidney 
                 0.8 
               
               
                   
                 Kidney (fetal) 
                 5.5 
               
               
                   
                 Renal ca. 786-0 
                 10.0 
               
               
                   
                 Renal ca. A498 
                 17.8 
               
               
                   
                 Renal ca. RXF 393 
                 11.0 
               
               
                   
                 Renal ca. ACHN 
                 6.9 
               
               
                   
                 Renal ca. UO-31 
                 14.4 
               
               
                   
                 Renal ca. TK-10 
                 0.2 
               
               
                   
                 Liver 
                 2.2 
               
               
                   
                 Liver (fetal) 
                 5.8 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.1 
               
               
                   
                 Lung 
                 27.9 
               
               
                   
                 Lung (fetal) 
                 14.0 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 3.4 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.2 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 3.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 9.7 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.8 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 1.3 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 19.3 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 33.2 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
               
               
                   
                 Mammary gland 
                 5.6 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 62.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 11.1 
               
               
                   
                 Breast ca. MDA-N 
                 5.9 
               
               
                   
                 Ovary 
                 3.5 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 1.7 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.1 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 5.9 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 3.6 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.6 
               
               
                   
                 Uterus 
                 2.7 
               
               
                   
                 Placenta 
                 59.0 
               
               
                   
                 Prostate 
                 1.7 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 3.1 
               
               
                   
                 Testis 
                 3.7 
               
               
                   
                 Melanoma Hs688(A).T 
                 15.1 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 9.7 
               
               
                   
                 Melanoma UACC-62 
                 1.4 
               
               
                   
                 Melanoma M14 
                 0.1 
               
               
                   
                 Melanoma LOX IMVI 
                 17.8 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 7.4 
               
               
                   
                 Adipose 
                 5.1 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1544, Run 146169090    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AMC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Normal Colon 
                 15.7 
                 2.5 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 5.1 
                 0.8 
               
               
                   
                 CC Margin (ODO3866) 
                 3.8 
                 0.5 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 3.3 
                 1.2 
               
               
                   
                 CC Margin (ODO3868) 
                 0.0 
                 0.1 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 2.6 
                 1.8 
               
               
                   
                 CC Margin (ODO3920) 
                 3.0 
                 2.2 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 6.7 
                 4.0 
               
               
                   
                 CC Margin (ODO3921) 
                 1.6 
                 0.9 
               
               
                   
                 CC from Partial Hepatectomy 
                 6.0 
                 5.4 
               
               
                   
                 (ODO4309) Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 9.8 
                 4.7 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 7.3 
                 7.2 
               
               
                   
                 Lung Margin (OD04451-02) 
                 13.6 
                 2.4 
               
               
                   
                 Normal Prostate 6546-1 
                 3.5 
                 2.2 
               
               
                   
                 Prostate Cancer (OD04410) 
                 5.1 
                 3.7 
               
               
                   
                 Prostate Margin (OD04410) 
                 4.5 
                 8.0 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 6.3 
                 7.1 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 8.1 
                 11.5 
               
               
                   
                 Normal Lung 061010 
                 34.2 
                 49.0 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 25.7 
                 58.2 
               
               
                   
                 Muscle Margin (ODO4286) 
                 5.7 
                 4.9 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 13.9 
                 25.7 
               
               
                   
                 Lung Margin (OD03126) 
                 39.0 
                 32.3 
               
               
                   
                 Lung Cancer (OD04404) 
                 27.4 
                 15.1 
               
               
                   
                 Lung Margin (OD04404) 
                 25.0 
                 4.9 
               
               
                   
                 Lung Cancer (OD04565) 
                 6.2 
                 5.8 
               
               
                   
                 Lung Margin (OD04565) 
                 12.9 
                 17.1 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 27.5 
                 17.6 
               
               
                   
                 Lung Margin (OD04237-02) 
                 100.0 
                 28.9 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 3.3 
                 3.9 
               
               
                   
                 Liver Margin (ODO4310) 
                 5.0 
                 5.6 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 5.5 
                 3.7 
               
               
                   
                 Lung Margin (OD04321) 
                 35.8 
                 32.1 
               
               
                   
                 Normal Kidney 
                 12.1 
                 4.8 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 12.7 
                 11.9 
               
               
                   
                 Kidney Margin (OD04338) 
                 6.7 
                 2.6 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 14.7 
                 9.2 
               
               
                   
                 Kidney Margin (OD04339) 
                 6.6 
                 3.2 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 7.3 
                 9.4 
               
               
                   
                 Kidney Margin (OD04340) 
                 8.2 
                 5.1 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 6.7 
                 8.1 
               
               
                   
                 Kidney Margin (OD04348) 
                 17.9 
                 18.9 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 7.5 
                 15.9 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 1.9 
                 0.7 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 1.7 
                 2.3 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 6.5 
                 5.9 
               
               
                   
                 Kidney Cancer 8120607 
                 4.5 
                 2.5 
               
               
                   
                 Kidney Margin 8120608 
                 0.7 
                 0.8 
               
               
                   
                 Kidney Cancer 8120613 
                 1.2 
                 1.7 
               
               
                   
                 Kidney Margin 8120614 
                 0.0 
                 0.3 
               
               
                   
                 Kidney Cancer 9010320 
                 4.7 
                 1.2 
               
               
                   
                 Kidney Margin 9010321 
                 2.1 
                 0.7 
               
               
                   
                 Normal Uterus 
                 2.7 
                 1.6 
               
               
                   
                 Uterus Cancer 064011 
                 6.0 
                 6.3 
               
               
                   
                 Normal Thyroid 
                 7.3 
                 4.5 
               
               
                   
                 Thyroid Cancer 064010 
                 36.3 
                 29.9 
               
               
                   
                 Thyroid Cancer A302152 
                 11.6 
                 13.8 
               
               
                   
                 Thyroid Margin A302153 
                 15.7 
                 9.9 
               
               
                   
                 Normal Breast 
                 5.2 
                 3.9 
               
               
                   
                 Breast Cancer (OD04566) 
                 5.0 
                 3.3 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 8.6 
                 2.3 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 6.7 
                 7.2 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 6.6 
                 5.6 
               
               
                   
                 Breast Cancer 064006 
                 15.3 
                 11.2 
               
               
                   
                 Breast Cancer 1024 
                 1.9 
                 0.9 
               
               
                   
                 Breast Cancer 9100266 
                 3.1 
                 3.5 
               
               
                   
                 Breast Margin 9100265 
                 2.4 
                 1.9 
               
               
                   
                 Breast Cancer A209073 
                 5.1 
                 7.2 
               
               
                   
                 Breast Margin A209073 
                 5.4 
                 1.2 
               
               
                   
                 Normal Liver 
                 6.0 
                 4.3 
               
               
                   
                 Liver Cancer 064003 
                 4.7 
                 1.1 
               
               
                   
                 Liver Cancer 1025 
                 1.8 
                 1.5 
               
               
                   
                 Liver Cancer 1026 
                 0.0 
                 0.5 
               
               
                   
                 Liver Cancer 6004-T 
                 4.3 
                 1.1 
               
               
                   
                 Liver Tissue 6004-N 
                 4.2 
                 1.3 
               
               
                   
                 Liver Cancer 6005-T 
                 0.5 
                 0.4 
               
               
                   
                 Liver Tissue 6005-N 
                 1.6 
                 1.0 
               
               
                   
                 Normal Bladder 
                 11.3 
                 12.7 
               
               
                   
                 Bladder Cancer 1023 
                 1.8 
                 1.3 
               
               
                   
                 Bladder Cancer A302173 
                 50.0 
                 16.7 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 96.6 
                 100.0 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 11.1 
                 4.6 
               
               
                   
                 Normal Ovary 
                 0.3 
                 0.4 
               
               
                   
                 Ovarian Cancer 064008 
                 7.4 
                 3.4 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 23.0 
                 0.4 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 5.5 
                 2.0 
               
               
                   
                 Normal Stomach 
                 5.2 
                 2.1 
               
               
                   
                 Gastric Cancer 9060358 
                 1.8 
                 0.4 
               
               
                   
                 Stomach Margin 9060359 
                 2.3 
                 1.3 
               
               
                   
                 Gastric Cancer 9060395 
                 5.9 
                 2.0 
               
               
                   
                 Stomach Margin 9060394 
                 5.0 
                 1.9 
               
               
                   
                 Gastric Cancer 9060397 
                 6.0 
                 2.6 
               
               
                   
                 Stomach Margin 9060396 
                 2.1 
                 1.5 
               
               
                   
                 Gastric Cancer 064005 
                 10.9 
                 10.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1544, Run 145030196    
               
               
                   
                   Column B - Rel. Exp. (%) Ag1544, Run 145361330    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AMD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 7.9 
               
               
                   
                 Secondary Th2 act 
                 11.7 
               
               
                   
                 Secondary Tr1 act 
                 7.3 
               
               
                   
                 Secondary Th1 rest 
                 0.8 
               
               
                   
                 Secondary Th2 rest 
                 1.2 
               
               
                   
                 Secondary Tr1 rest 
                 1.1 
               
               
                   
                 Primary Th1 act 
                 6.7 
               
               
                   
                 Primary Th2 act 
                 4.5 
               
               
                   
                 Primary Tr1 act 
                 5.9 
               
               
                   
                 Primary Th1 rest 
                 0.4 
               
               
                   
                 Primary Th2 rest 
                 0.3 
               
               
                   
                 Primary Tr1 rest 
                 0.3 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 5.8 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 6.5 
               
               
                   
                 CD8 lymphocyte act 
                 2.5 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 5.9 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.7 
               
               
                   
                 CD4 lymphocyte none 
                 0.4 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 1.7 
               
               
                   
                 LAK cells rest 
                 23.8 
               
               
                   
                 LAK cells IL-2 
                 2.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 3.1 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 5.6 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 6.6 
               
               
                   
                 LAK cells PMA/ionomycin 
                 77.9 
               
               
                   
                 NK Cells IL-2 rest 
                 1.5 
               
               
                   
                 Two Way MLR 3 day 
                 21.6 
               
               
                   
                 Two Way MLR 5 day 
                 18.9 
               
               
                   
                 Two Way MLR 7 day 
                 5.1 
               
               
                   
                 PBMC rest 
                 0.3 
               
               
                   
                 PBMC PWM 
                 11.5 
               
               
                   
                 PBMC PHA-L 
                 8.4 
               
               
                   
                 Ramos (B cell) none 
                 0.2 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.3 
               
               
                   
                 B lymphocytes PWM 
                 2.8 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 1.2 
               
               
                   
                 EOL-1 dbcAMP 
                 0.1 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.2 
               
               
                   
                 Dendritic cells none 
                 19.9 
               
               
                   
                 Dendritic cells LPS 
                 58.2 
               
               
                   
                 Dendritic cells anti-CD40 
                 12.6 
               
               
                   
                 Monocytes rest 
                 0.1 
               
               
                   
                 Monocytes LPS 
                 100.0 
               
               
                   
                 Macrophages rest 
                 4.6 
               
               
                   
                 Macrophages LPS 
                 32.3 
               
               
                   
                 HUVEC none 
                 2.0 
               
               
                   
                 HUVEC starved 
                 3.2 
               
               
                   
                 HUVEC IL-1beta 
                 4.0 
               
               
                   
                 HUVEC IFN gamma 
                 18.4 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 19.5 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 2.8 
               
               
                   
                 HUVEC IL-11 
                 2.0 
               
               
                   
                 Lung Microvascular EC none 
                 7.5 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 3.5 
               
               
                   
                 Microvascular Dermal EC none 
                 5.2 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 1.4 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 1.1 
               
               
                   
                 Small airway epithelium none 
                 0.7 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 2.3 
               
               
                   
                 Coronery artery SMC rest 
                 1.4 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 1.8 
               
               
                   
                 Astrocytes rest 
                 3.3 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 5.8 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.3 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 5.4 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 19.9 
               
               
                   
                 Liver cirrhosis 
                 0.2 
               
               
                   
                 NCI-H292 none 
                 0.8 
               
               
                   
                 NCI-H292 IL-4 
                 1.4 
               
               
                   
                 NCI-H292 IL-9 
                 1.0 
               
               
                   
                 NCI-H292 IL-13 
                 1.6 
               
               
                   
                 NCI-H292 IFN gamma 
                 4.2 
               
               
                   
                 HPAEC none 
                 2.4 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 4.7 
               
               
                   
                 Lung fibroblast none 
                 0.8 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 1.6 
               
               
                   
                 Lung fibroblast IL-4 
                 1.5 
               
               
                   
                 Lung fibroblast IL-9 
                 1.7 
               
               
                   
                 Lung fibroblast IL-13 
                 1.1 
               
               
                   
                 Lung fibroblast IFN gamma 
                 15.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 2.8 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 4.9 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 4.0 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 3.7 
               
               
                   
                 Dermal fibroblast IL-4 
                 0.7 
               
               
                   
                 Dermal Fibroblasts rest 
                 0.2 
               
               
                   
                 Neutrophils TNFa + LPS 
                 0.4 
               
               
                   
                 Neutrophils rest 
                 0.6 
               
               
                   
                 Colon 
                 0.2 
               
               
                   
                 Lung 
                 0.6 
               
               
                   
                 Thymus 
                 4.5 
               
               
                   
                 Kidney 
                 0.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1544, Run 209988812    
               
            
           
         
       
     
      Panel 1.3D Summary: Ag1544 The expression of this gene was highest in a sample derived from a gastric cancer cell line (NCI-H87) (CT=27.3). There was substantial expression found in lung cancer cell lines, a breast cancer cell line and placental tissue. The expression of this gene is useful as a marker to distinguish NCI-H87 cells from other samples in the panel. Therapeutic modulation of this gene or its protein product, through the use of small molecule drugs, antibodies or protein therapeutics is beneficial in the treatment of lung cancer or breast cancer.  
      Panel 2D Summary: Ag1544 The expression of this gene was highest expression associated with bladder cancer tissue and lung tissue derived samples. The expression of this gene is useful as a marker to distinguish between these samples and the rest of the samples in the panel. Therapeutic modulation of this gene, through the use of small molecule drugs, antibodies or protein therapeutics are beneficial in the treatment of bladder or lung cancer.  
      Panel 4.1D Summary: Ag1544 This transcript was expressed in LAK cells, and induced in LAK cells activated with PMA/ionomycin, dendritic cells treated with LPS, monocytes treated with LPS, Gamma interferon treated HUEC cells and keratinocytes treated with TNFalpha and IL-1beta. This transcript encodes a smaller isoform of B7-H1, an antigen presentation co-receptor. B7-H1 binds to PD-1 ligand on T cells, resulting in T cell activation and production of IL-10. Antibody or other types of therapeutics designed with B7-H1 are useful for blocking T cell activation and for the treatment of T cell-mediated diseases such as asthma, psoriasis, IBD and arthritis. Alternatively, agonistic therapeutics designed with this protein are useful for adjuvant or immuno-modulatory treatments.  
      AN. CG56110-07: B7-H1  
      Expression of full-length physical clone CG56110-07 was assessed using the primer-probe set Ag5282, described in Table ANA. Results of the RTQ-PCR runs are shown in Tables ANB and ANC.  
               TABLE ANA                          Probe Name Ag5282                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-tcaagtcctgagtggagattagat-3′   24   491   1474                   Probe   TET-5′-tggtcatcccagaactacctctggca-3′-   26   540   1475           TAMRA               Reverse   5′-cccagaattaccaagtgagtcct-3′   23   581   1476                  
 
     
       
         
           
               
             
               
                 TABLE ANB 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.5 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 0.0 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 5.1 
               
               
                   
                 Melanoma* M14 
                 0.6 
               
               
                   
                 Melanoma* LOXIMVI 
                 23.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 3.6 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 10.9 
               
               
                   
                 Testis Pool 
                 0.0 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate Pool 
                 1.2 
               
               
                   
                 Placenta 
                 2.8 
               
               
                   
                 Uterus Pool 
                 2.8 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 2.7 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 6.1 
               
               
                   
                 Ovarian ca. IGROV-1 
                 5.4 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 1.3 
               
               
                   
                 Ovary 
                 0.0 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 31.2 
               
               
                   
                 Breast ca. BT 549 
                 3.6 
               
               
                   
                 Breast ca. T47D 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 3.7 
               
               
                   
                 Breast Pool 
                 0.5 
               
               
                   
                 Trachea 
                 1.1 
               
               
                   
                 Lung 
                 1.2 
               
               
                   
                 Fetal Lung 
                 1.3 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 2.7 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.0 
               
               
                   
                 Lung ca. A549 
                 0.0 
               
               
                   
                 Lung ca. NCI-H526 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 0.8 
               
               
                   
                 Lung ca. NCI-H460 
                 1.4 
               
               
                   
                 Lung ca. HOP-62 
                 13.1 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 0.0 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
               
               
                   
                 Kidney Pool 
                 3.1 
               
               
                   
                 Fetal Kidney 
                 0.0 
               
               
                   
                 Renal ca. 786-0 
                 5.1 
               
               
                   
                 Renal ca. A498 
                 2.1 
               
               
                   
                 Renal ca. ACHN 
                 1.3 
               
               
                   
                 Renal ca. UO-31 
                 6.8 
               
               
                   
                 Renal ca. TK-10 
                 0.7 
               
               
                   
                 Bladder 
                 4.0 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 100.0 
               
               
                   
                 Gastric ca. KATO III 
                 4.2 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 2.2 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 3.6 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon cancer tissue 
                 1.8 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 4.8 
               
               
                   
                 Small Intestine Pool 
                 4.3 
               
               
                   
                 Stomach Pool 
                 0.0 
               
               
                   
                 Bone Marrow Pool 
                 0.9 
               
               
                   
                 Fetal Heart 
                 3.9 
               
               
                   
                 Heart Pool 
                 2.3 
               
               
                   
                 Lymph Node Pool 
                 0.0 
               
               
                   
                 Fetal Skeletal Muscle 
                 1.2 
               
               
                   
                 Skeletal Muscle Pool 
                 3.1 
               
               
                   
                 Spleen Pool 
                 3.9 
               
               
                   
                 Thymus Pool 
                 3.9 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 21.9 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 3.5 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 1.4 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 2.5 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 8.7 
               
               
                   
                 CNS cancer (glio) SF-295 
                 3.6 
               
               
                   
                 Brain (Amygdala) Pool 
                 0.0 
               
               
                   
                 Brain (cerebellum) 
                 1.3 
               
               
                   
                 Brain (fetal) 
                 0.0 
               
               
                   
                 Brain (Hippocampus) Pool 
                 0.0 
               
               
                   
                 Cerebral Cortex Pool 
                 2.1 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 0.0 
               
               
                   
                 Brain (Thalamus) Pool 
                 0.9 
               
               
                   
                 Brain (whole) 
                 0.0 
               
               
                   
                 Spinal Cord Pool 
                 1.4 
               
               
                   
                 Adrenal Gland 
                 2.2 
               
               
                   
                 Pituitary gland Pool 
                 0.0 
               
               
                   
                 Salivary Gland 
                 0.0 
               
               
                   
                 Thyroid (female) 
                 2.5 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 12.3 
               
               
                   
                 Pancreas Pool 
                 1.8 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag5282, Run 230565189    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ANC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 5.6 
               
               
                   
                 Secondary Th2 act 
                 18.6 
               
               
                   
                 Secondary Tr1 act 
                 4.9 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.3 
               
               
                   
                 Secondary Tr1 rest 
                 0.9 
               
               
                   
                 Primary Th1 act 
                 4.6 
               
               
                   
                 Primary Th2 act 
                 4.1 
               
               
                   
                 Primary Tr1 act 
                 9.7 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.8 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 9.8 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 13.1 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 6.7 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.8 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 14.0 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 1.9 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 1.7 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 3.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 76.3 
               
               
                   
                 NK Cells IL-2 rest 
                 1.0 
               
               
                   
                 Two Way MLR 3 day 
                 9.4 
               
               
                   
                 Two Way MLR 5 day 
                 4.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.7 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 6.1 
               
               
                   
                 PBMC PHA-L 
                 6.1 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 3.6 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 10.2 
               
               
                   
                 Dendritic cells LPS 
                 36.1 
               
               
                   
                 Dendritic cells anti-CD40 
                 4.8 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 100.0 
               
               
                   
                 Macrophages rest 
                 2.6 
               
               
                   
                 Macrophages LPS 
                 5.0 
               
               
                   
                 HUVEC none 
                 2.2 
               
               
                   
                 HUVEC starved 
                 3.8 
               
               
                   
                 HUVEC IL-1beta 
                 1.7 
               
               
                   
                 HUVEC IFN gamma 
                 25.5 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 13.9 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 2.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 9.9 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.8 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.3 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.3 
               
               
                   
                 Small airway epithelium none 
                 2.3 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 2.2 
               
               
                   
                 Coronery artery SMC rest 
                 1.0 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 1.9 
               
               
                   
                 Astrocytes rest 
                 1.8 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 5.3 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 1.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 5.5 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 18.8 
               
               
                   
                 Liver cirrhosis 
                 0.0 
               
               
                   
                 NCI-H292 none 
                 0.0 
               
               
                   
                 NCI-H292 IL-4 
                 1.0 
               
               
                   
                 NCI-H292 IL-9 
                 1.0 
               
               
                   
                 NCI-H292 IL-13 
                 1.5 
               
               
                   
                 NCI-H292 IFN gamma 
                 8.8 
               
               
                   
                 HPAEC none 
                 0.9 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 6.0 
               
               
                   
                 Lung fibroblast none 
                 0.0 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 1.0 
               
               
                   
                 Lung fibroblast IL-4 
                 2.3 
               
               
                   
                 Lung fibroblast IL-9 
                 1.6 
               
               
                   
                 Lung fibroblast IL-13 
                 0.0 
               
               
                   
                 Lung fibroblast IFN gamma 
                 17.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 6.6 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 9.4 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 5.3 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 2.8 
               
               
                   
                 Dermal fibroblast IL-4 
                 0.0 
               
               
                   
                 Dermal Fibroblasts rest 
                 0.0 
               
               
                   
                 Neutrophils TNFa + LPS 
                 0.9 
               
               
                   
                 Neutrophils rest 
                 0.0 
               
               
                   
                 Colon 
                 0.0 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Thymus 
                 0.0 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag5282, Run 230510202    
               
            
           
         
       
     
      General_screening_panel_v1.5 Summary: Ag5282 The expression of this gene was highest in a sample derived from a gastric cancer cell line (NCI-H87) (CT=31).  
      There was relatively low expression in the remaining samples of panel 1.5. The expression of this gene is useful as a marker to distinguish NCI-H87 cells from other samples in the panel.  
      In addition, low expression of this gene was also seen in number of cancer cell lines derived from melanoma, pancreatic, gastric, renal, squamous cell carcinoma and lung cancers. Therapeutic modulation of this gene or its protein product is useful in the treatment of these cancers.  
      Panel 4.1D Summary: Ag5282 This transcript was not expressed in the normal tissue samples on this panel. The transcript was expressed in LAK cells, and induced in LAK cells activated with PMA/ionomycin, dendritic cells treated with LPS, monocytes treated with LPS, Gamma interferon treated HUVEC cells and keratinocytes treated with TNFalpha and IL-1beta. This transcript encodes a smaller isoform of B7-H1, an antigen presentation co-receptor. B7-H1 binds to PD-1 ligand on T cells and resulting in T cell activation and production of IL-10. Antibody or other types of therapeutics designed with B7-H1 are useful for blocking T cell activation and in the treatment of T cell-mediated diseases such as asthma, psoriasis, IBD and arthritis. Alternatively, agonistic therapeutics designed with this protein are useful for adjuvant like properties.  
      AO. CG56449-09: MEGF6/NOTCH like Isoform 7  
      Expression of gene CG56449-09 was assessed using the primer-probe sets Ag1153, Ag1937, Ag422 and Ag252 and, described in Tables AOA, AOB, AOC, and AOD. Results of the RTQ-PCR runs are shown in Tables AOE, AOF, and AOG.  
               TABLE AOA                          Probe Name Ag1513                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-acacacgctcacagagaagttt-3′   22   1521   1477                   Probe   TET-5′-ctggatgactcctttggccatgact-3′-   25   1549   1478           TAMRA       Reverse   5′-ctgcagtcatcacaggtcaag-3′   21   1578   1479                  
 
     
       
         
           
               
             
               
                 TABLE AOB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag1937 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-ctgcagtcatcacaggtcaag-3′ 
                 21 
                 1578 
                 1480 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ccaaaggagtcatccaggcagacaaa-3′- 
                 26 
                 1540 
                 1481 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-gaacacacgctcacagagaag-3′ 
                 21 
                 1519 1482 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AOC 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag422 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-tgaacaccccaggctcctac-3′ 
                 20 
                 545 
                 1483 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-cggcttccggctccacactgac-3′- 
                 22 
                 582 
                 1484 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-taatggccaggcaggtcct-3′ 
                 19 
                 607 
                 1485 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AOD 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag252 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-gagctgccgcaactcttcc-3′ 
                 19 
                 1453 
                 1486 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-cgcaactctgcctcttcctcatcgg-3′- 
                 25 
                 1490 
                 1487 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-gacaaacttctctgtgagcgtgtg-3′ 
                 24 
                 1522 
                 1488 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AOE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 13.9 
               
               
                   
                 Pancreas 
                 4.7 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 4.1 
               
               
                   
                 Adrenal gland 
                 6.7 
               
               
                   
                 Thyroid 
                 5.1 
               
               
                   
                 Salivary gland 
                 13.6 
               
               
                   
                 Pituitary gland 
                 5.5 
               
               
                   
                 Brain (fetal) 
                 28.5 
               
               
                   
                 Brain (whole) 
                 43.8 
               
               
                   
                 Brain (amygdala) 
                 32.3 
               
               
                   
                 Brain (cerebellum) 
                 42.9 
               
               
                   
                 Brain (hippocampus) 
                 44.1 
               
               
                   
                 Brain (substantia nigra) 
                 4.1 
               
               
                   
                 Brain (thalamus) 
                 14.8 
               
               
                   
                 Cerebral Cortex 
                 25.5 
               
               
                   
                 Spinal cord 
                 2.6 
               
               
                   
                 glio/astro U87-MG 
                 2.0 
               
               
                   
                 glio/astro U-118-MG 
                 10.2 
               
               
                   
                 astrocytoma SW1783 
                 10.6 
               
               
                   
                 neuro*; met SK-N-AS 
                 1.7 
               
               
                   
                 astrocytoma SF-539 
                 4.9 
               
               
                   
                 astrocytoma SNB-75 
                 10.1 
               
               
                   
                 glioma SNB-19 
                 6.6 
               
               
                   
                 glioma U251 
                 8.4 
               
               
                   
                 glioma SF-295 
                 1.4 
               
               
                   
                 Heart (fetal) 
                 11.8 
               
               
                   
                 Heart 
                 7.6 
               
               
                   
                 Skeletal muscle (fetal) 
                 7.4 
               
               
                   
                 Skeletal muscle 
                 0.0 
               
               
                   
                 Bone marrow 
                 1.8 
               
               
                   
                 Thymus 
                 12.1 
               
               
                   
                 Spleen 
                 0.0 
               
               
                   
                 Lymph node 
                 15.7 
               
               
                   
                 Colorectal 
                 0.0 
               
               
                   
                 Stomach 
                 4.9 
               
               
                   
                 Small intestine 
                 13.7 
               
               
                   
                 Colon ca. SW480 
                 12.0 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 2.9 
               
               
                   
                 Colon ca. HT29 
                 2.3 
               
               
                   
                 Colon ca. HCT-116 
                 2.9 
               
               
                   
                 Colon ca. CaCo-2 
                 2.9 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 2.9 
               
               
                   
                 Colon ca. HCC-2998 
                 2.8 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 12.9 
               
               
                   
                 Bladder 
                 4.1 
               
               
                   
                 Trachea 
                 34.2 
               
               
                   
                 Kidney 
                 4.7 
               
               
                   
                 Kidney (fetal) 
                 22.8 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 19.5 
               
               
                   
                 Renal ca. RXF 393 
                 53.2 
               
               
                   
                 Renal ca. ACHN 
                 2.4 
               
               
                   
                 Renal ca. UO-31 
                 1.4 
               
               
                   
                 Renal ca. TK-10 
                 1.4 
               
               
                   
                 Liver 
                 3.2 
               
               
                   
                 Liver (fetal) 
                 1.4 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 100.0 
               
               
                   
                 Lung 
                 6.3 
               
               
                   
                 Lung (fetal) 
                 10.2 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 2.8 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 64.2 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 5.9 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 6.4 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 3.3 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 21.6 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 11.9 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 40.9 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 1.7 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 23.3 
               
               
                   
                 Mammary gland 
                 6.9 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 6.8 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 47.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 22.4 
               
               
                   
                 Breast ca. MDA-N 
                 3.1 
               
               
                   
                 Ovary 
                 0.6 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 7.1 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 9.5 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 2.2 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 20.6 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 9.7 
               
               
                   
                 Uterus 
                 6.1 
               
               
                   
                 Placenta 
                 4.9 
               
               
                   
                 Prostate 
                 21.2 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 15.7 
               
               
                   
                 Testis 
                 5.0 
               
               
                   
                 Melanoma Hs688(A).T 
                 1.6 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 4.9 
               
               
                   
                 Melanoma UACC-62 
                 2.7 
               
               
                   
                 Melanoma M14 
                 3.2 
               
               
                   
                 Melanoma LOX IMVI 
                 3.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 1.3 
               
               
                   
                 Adipose 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag252, Run 165628866    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AOF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 11.3 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 11.0 
               
               
                   
                 CC Margin (ODO3866) 
                 1.6 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 9.7 
               
               
                   
                 CC Margin (ODO3868) 
                 2.5 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 20.9 
               
               
                   
                 CC Margin (ODO3920) 
                 3.0 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 3.2 
               
               
                   
                 CC Margin (ODO3921) 
                 1.8 
               
               
                   
                 CC from Partial Hepatectomy (ODO4309) Mets 
                 18.7 
               
               
                   
                 Liver Margin (ODO4309) 
                 2.3 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 14.0 
               
               
                   
                 Lung Margin (OD04451-02) 
                 17.1 
               
               
                   
                 Normal Prostate 6546-1 
                 20.6 
               
               
                   
                 Prostate Cancer (OD04410) 
                 30.1 
               
               
                   
                 Prostate Margin (OD04410) 
                 18.4 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 36.9 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 24.0 
               
               
                   
                 Normal Lung 061010 
                 15.3 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 1.5 
               
               
                   
                 Muscle Margin (ODO4286) 
                 11.1 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 23.5 
               
               
                   
                 Lung Margin (OD03126) 
                 19.5 
               
               
                   
                 Lung Cancer (OD04404) 
                 10.5 
               
               
                   
                 Lung Margin (OD04404) 
                 53.2 
               
               
                   
                 Lung Cancer (OD04565) 
                 12.9 
               
               
                   
                 Lung Margin (OD04565) 
                 23.8 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 4.9 
               
               
                   
                 Lung Margin (OD04237-02) 
                 32.5 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 2.0 
               
               
                   
                 Liver Margin (ODO4310) 
                 5.4 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.7 
               
               
                   
                 Lung Margin (OD04321) 
                 24.5 
               
               
                   
                 Normal Kidney 
                 8.3 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 22.5 
               
               
                   
                 Kidney Margin (OD04338) 
                 4.1 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 10.9 
               
               
                   
                 Kidney Margin (OD04339) 
                 6.5 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 26.8 
               
               
                   
                 Kidney Margin (OD04340) 
                 10.4 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 3.7 
               
               
                   
                 Kidney Margin (OD04348) 
                 6.0 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 100.0 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 6.5 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 4.5 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 7.4 
               
               
                   
                 Kidney Cancer 8120607 
                 3.5 
               
               
                   
                 Kidney Margin 8120608 
                 8.7 
               
               
                   
                 Kidney Cancer 8120613 
                 1.2 
               
               
                   
                 Kidney Margin 8120614 
                 6.1 
               
               
                   
                 Kidney Cancer 9010320 
                 12.5 
               
               
                   
                 Kidney Margin 9010321 
                 9.9 
               
               
                   
                 Normal Uterus 
                 18.9 
               
               
                   
                 Uterus Cancer 064011 
                 15.6 
               
               
                   
                 Normal Thyroid 
                 3.3 
               
               
                   
                 Thyroid Cancer 064010 
                 6.9 
               
               
                   
                 Thyroid Cancer A302152 
                 10.9 
               
               
                   
                 Thyroid Margin A302153 
                 5.7 
               
               
                   
                 Normal Breast 
                 42.3 
               
               
                   
                 Breast Cancer (OD04566) 
                 26.6 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 21.8 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 36.3 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 14.9 
               
               
                   
                 Breast Cancer 064006 
                 21.5 
               
               
                   
                 Breast Cancer 1024 
                 42.0 
               
               
                   
                 Breast Cancer 9100266 
                 11.0 
               
               
                   
                 Breast Margin 9100265 
                 10.8 
               
               
                   
                 Breast Cancer A209073 
                 14.9 
               
               
                   
                 Breast Margin A209073 
                 13.0 
               
               
                   
                 Normal Liver 
                 6.4 
               
               
                   
                 Liver Cancer 064003 
                 0.0 
               
               
                   
                 Liver Cancer 1025 
                 1.1 
               
               
                   
                 Liver Cancer 1026 
                 19.6 
               
               
                   
                 Liver Cancer 6004-T 
                 10.0 
               
               
                   
                 Liver Tissue 6004-N 
                 6.0 
               
               
                   
                 Liver Cancer 6005-T 
                 15.3 
               
               
                   
                 Liver Tissue 6005-N 
                 3.3 
               
               
                   
                 Normal Bladder 
                 19.2 
               
               
                   
                 Bladder Cancer 1023 
                 5.6 
               
               
                   
                 Bladder Cancer A302173 
                 3.4 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 7.6 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 9.3 
               
               
                   
                 Normal Ovary 
                 2.4 
               
               
                   
                 Ovarian Cancer 064008 
                 11.8 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 2.9 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 31.4 
               
               
                   
                 Normal Stomach 
                 5.6 
               
               
                   
                 Gastric Cancer 9060358 
                 0.0 
               
               
                   
                 Stomach Margin 9060359 
                 1.9 
               
               
                   
                 Gastric Cancer 9060395 
                 5.9 
               
               
                   
                 Stomach Margin 9060394 
                 2.4 
               
               
                   
                 Gastric Cancer 9060397 
                 18.6 
               
               
                   
                 Stomach Margin 9060396 
                 2.8 
               
               
                   
                 Gastric Cancer 064005 
                 1.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag252, Run 144791435    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AOG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Secondary Th1 act 
                 0.7 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 act 
                 0.8 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 act 
                 0.5 
                 0.0 
                 4.0 
               
               
                 Secondary Th1 rest 
                 1.7 
                 0.0 
                 5.6 
               
               
                 Secondary Th2 rest 
                 14.0 
                 10.0 
                 15.2 
               
               
                 Secondary Tr1 rest 
                 6.2 
                 0.0 
                 5.7 
               
               
                 Primary Th1 act 
                 1.9 
                 2.1 
                 1.1 
               
               
                 Primary Th2 act 
                 2.1 
                 2.3 
                 9.9 
               
               
                 Primary Tr1 act 
                 0.2 
                 0.6 
                 4.5 
               
               
                 Primary Th1 rest 
                 16.3 
                 10.0 
                 15.7 
               
               
                 Primary Th2 rest 
                 7.4 
                 9.1 
                 21.9 
               
               
                 Primary Tr1 rest 
                 11.6 
                 11.0 
                 13.9 
               
               
                 CD45RA CD4 lymphocyte act 
                 13.7 
                 9.4 
                 16.6 
               
               
                 CD45RO CD4 lymphocyte act 
                 1.1 
                 0.6 
                 3.1 
               
               
                 CD8 lymphocyte act 
                 1.5 
                 0.9 
                 1.1 
               
               
                 Secondary CD8 lymphocyte rest 
                 4.0 
                 3.3 
                 5.0 
               
               
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CD4 lymphocyte none 
                 19.8 
                 18.6 
                 30.8 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 6.2 
                 4.1 
                 19.9 
               
               
                 LAK cells rest 
                 8.4 
                 8.7 
                 17.4 
               
               
                 LAK cells IL-2 
                 1.6 
                 6.2 
                 5.8 
               
               
                 LAK cells IL-2 + IL-12 
                 4.3 
                 4.0 
                 8.4 
               
               
                 LAK cells IL-2 + IFN gamma 
                 1.0 
                 8.1 
                 4.1 
               
               
                 LAK cells IL-2 + IL-18 
                 1.3 
                 8.3 
                 1.3 
               
               
                 LAK cells PMA/ionomycin 
                 2.6 
                 1.2 
                 2.5 
               
               
                 NK Cells IL-2 rest 
                 1.2 
                 4.8 
                 6.8 
               
               
                 Two Way MLR 3 day 
                 8.1 
                 13.5 
                 3.7 
               
               
                 Two Way MLR 5 day 
                 1.3 
                 5.0 
                 1.4 
               
               
                 Two Way MLR 7 day 
                 1.0 
                 2.0 
                 2.6 
               
               
                 PBMC rest 
                 3.0 
                 3.7 
                 7.8 
               
               
                 PBMC PWM 
                 5.2 
                 2.3 
                 3.6 
               
               
                 PBMC PHA-L 
                 1.0 
                 1.9 
                 2.6 
               
               
                 Ramos (B cell) none 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
                 0.0 
               
               
                 B lymphocytes PWM 
                 1.1 
                 1.4 
                 1.4 
               
               
                 B lymphocytes CD40L and IL-4 
                 2.1 
                 3.7 
                 8.1 
               
               
                 EOL-1 dbcAMP 
                 4.7 
                 3.4 
                 4.3 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 3.6 
                 1.3 
                 10.7 
               
               
                 Dendritic cells none 
                 1.7 
                 1.9 
                 3.3 
               
               
                 Dendritic cells LPS 
                 0.0 
                 0.0 
                 1.2 
               
               
                 Dendritic cells anti-CD40 
                 1.6 
                 0.6 
                 1.8 
               
               
                 Monocytes rest 
                 5.0 
                 4.8 
                 6.3 
               
               
                 Monocytes LPS 
                 0.4 
                 0.6 
                 1.4 
               
               
                 Macrophages rest 
                 12.3 
                 9.0 
                 13.8 
               
               
                 Macrophages LPS 
                 0.5 
                 0.6 
                 0.0 
               
               
                 HUVEC none 
                 4.2 
                 22.5 
                 15.6 
               
               
                 HUVEC starved 
                 17.3 
                 22.7 
                 17.1 
               
               
                 HUVEC IL-1beta 
                 2.9 
                 2.0 
                 3.5 
               
               
                 HUVEC IFN gamma 
                 27.2 
                 18.4 
                 25.9 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 8.5 
                 9.9 
                 2.0 
               
               
                 HUVEC TNF alpha + IL4 
                 7.9 
                 5.9 
                 13.7 
               
               
                 HUVEC IL-11 
                 15.6 
                 15.9 
                 17.8 
               
               
                 Lung Microvascular EC none 
                 27.7 
                 25.7 
                 23.8 
               
               
                 Lung Microvascular EC TNFalpha + 
                 24.0 
                 22.5 
                 19.1 
               
               
                 IL-1beta 
               
               
                 Microvascular Dermal EC none 
                 14.2 
                 15.9 
                 17.4 
               
               
                 Microsvasular Dermal EC TNFalpha + 
                 8.2 
                 9.4 
                 25.3 
               
               
                 IL-1beta 
               
               
                 Bronchial epithelium TNFalpha + 
                 4.0 
                 2.2 
                 1.3 
               
               
                 IL1beta 
               
               
                 Small airway epithelium none 
                 1.9 
                 1.6 
                 1.5 
               
               
                 Small airway epithelium TNFalpha + 
                 0.5 
                 6.4 
                 2.6 
               
               
                 IL-1beta 
               
               
                 Coronery artery SMC rest 
                 23.2 
                 29.7 
                 33.9 
               
               
                 Coronery artery SMC TNFalpha + 
                 33.4 
                 19.5 
                 13.5 
               
               
                 IL-1beta 
               
               
                 Astrocytes rest 
                 0.0 
                 26.6 
                 17.2 
               
               
                 Astrocytes TNFalpha + IL-1beta 
                 100.0 
                 100.0 
                 100.0 
               
               
                 KU-812 (Basophil) rest 
                 0.6 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
                 0.5 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) none 
                 1.9 
                 0.6 
                 3.5 
               
               
                 CCD1106 (Keratinocytes) TNFalpha + 
                 0.5 
                 2.1 
                 3.8 
               
               
                 IL-1beta 
               
               
                 Liver cirrhosis 
                 9.1 
                 12.2 
                 13.0 
               
               
                 Lupus kidney 
                 3.0 
                 2.6 
                 3.8 
               
               
                 NCI-H292 none 
                 30.1 
                 41.8 
                 25.7 
               
               
                 NCI-H292 IL-4 
                 16.8 
                 35.1 
                 16.5 
               
               
                 NCI-H292 IL-9 
                 21.9 
                 28.5 
                 32.8 
               
               
                 NCI-H292 IL-13 
                 37.6 
                 28.1 
                 33.7 
               
               
                 NCI-H292 IFN gamma 
                 20.3 
                 23.5 
                 22.5 
               
               
                 HPAEC none 
                 36.1 
                 23.5 
                 31.6 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 22.7 
                 11.1 
                 24.5 
               
               
                 Lung fibroblast none 
                 10.7 
                 15.0 
                 14.4 
               
               
                 Lung fibroblast TNF alpha + IL-1 beta 
                 1.9 
                 2.6 
                 1.2 
               
               
                 Lung fibroblast IL-4 
                 11.0 
                 9.7 
                 7.7 
               
               
                 Lung fibroblast IL-9 
                 11.3 
                 9.3 
                 13.2 
               
               
                 Lung fibroblast IL-13 
                 7.3 
                 4.5 
                 17.4 
               
               
                 Lung fibroblast IFN gamma 
                 7.1 
                 10.6 
                 9.4 
               
               
                 Dermal fibroblast CCD1070 rest 
                 33.2 
                 51.4 
                 45.4 
               
               
                 Dermal fibroblast CCD1070 TNF 
                 24.0 
                 31.9 
                 21.3 
               
               
                 alpha 
               
               
                 Dermal fibroblast CCD1070 IL-1 
                 34.6 
                 34.4 
                 46.3 
               
               
                 beta 
               
               
                 Dermal fibroblast IFN gamma 
                 30.6 
                 27.0 
                 32.3 
               
               
                 Dermal fibroblast IL-4 
                 34.4 
                 29.7 
                 33.9 
               
               
                 IBD Colitis 2 
                 1.7 
                 1.4 
                 3.0 
               
               
                 IBD Crohn&#39;s 
                 0.7 
                 0.0 
                 1.3 
               
               
                 Colon 
                 12.9 
                 9.2 
                 25.0 
               
               
                 Lung 
                 25.7 
                 55.5 
                 42.9 
               
               
                 Thymus 
                 12.2 
                 18.0 
                 18.3 
               
               
                 Kidney 
                 26.8 
                 39.2 
                 25.3 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag1513, Run 163478079    
               
               
                   Column B - Rel. Exp. (%) Ag1937, Run 161702009    
               
               
                   Column C - Rel. Exp. (%) Ag422, Run 138056654    
               
            
           
         
       
     
      Panel 1.3D Summary: Ag252 Highest levels of expression of this gene were seen in a liver cell line HepG2(CT=30.27). Based on expression in this panel, this gene is involved in brain, colon, renal, lung, ovarian and prostate cancer as well as melanomas. Thus, expression of this is useful as a diagnostic marker for the presence of these cancers. Therapeutic inhibition using antibodies, protein therapeutics or small molecule drugs are of use in the treatment of these cancers.  
      This gene product also showed low but significant levels of expression in pancreas, adrenal, thyroid, pituitary, adult and fetal heart, and adult and fetal liver. This gene or its protein product is important for the pathogenesis, diagnosis, and/or treatment of metabolic and endocrine diseases, including obesity and Types 1 and 2 diabetes. Furthermore, this gene was more highly expressed in fetal (CT=34) skeletal muscle when compared to expression in the adult (CT=40) and is useful for the differentiation of the fetal and adult sources of this tissue.  
      In addition, this gene was expressed at moderate levels in the CNS. This gene encodes a mouse epidermal growth factor homolog, and increases axonal or dendritic outgrowth and synaptogenesis. This gene is of use in the treatment of clinical conditions associated with neuron loss such as head or spinal cord trauma, stroke, or any neurodegenerative disease.  
      Panel 2D Summary: Ag252 This gene was expressed at low levels in all the samples on this panel, with highest expression in a kidney cancer sample (CT=31.1). Gastric, liver and colon cancers expressed this gene at a higher level than the normal adjacent tissue from these organs. There was increased expression in normal lung and ovarian tissue when compared to the adjacent tumor samples. These data show that the expression of this gene is associated with gastric, liver and colon cancer and thus, therapeutic modulation of this gene product is of use in the treatment of these cancers. Conversely, absence of expression is associated with ovarian and lung cancer and is of use as a diagnostic marker for the presence of these cancers. Therapeutic modulation of this gene is of use in the treatment of these cancers.  
      Panel 4D Summary: This transcript was expressed at low levels in T cells, fibroblasts, endothelium, smooth muscle cells and T cells regardless of treatment. The transcript was also expressed in normal colon, lung and thymus. However, TNFalpha and IL-1beta induce the expression of the transcript in astrocytes. The trancritpt encodes a Notch like protein which functions in astrocyte differentiation and activation. (Colombatti Glia 2001 September; 35(3):224-33). Therapeutic regulation of this transcript or the design of therapeutics with the encoded protein is important in the treatment of multiple scelrosis or other inflammtory diseases of the CNS.  
      AP. CG5659401: Claudin-19 Like  
      Expression of gene CG56594-01 was assessed using the primer-probe set Ag2957, described in Table APA. Results of the RTQ-PCR runs are shown in Tables APB, APC and APD.  
               TABLE APA                          Probe Name Ag2957                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-caggcctctgcactttgac-3′   19   438   1489                   Probe   TET-5′-ctgtctcgtggtatgccaccctggt-3′-   25   459   1490           TAMRA               Reverse   5′-ccaaattctgggttgaagaact-3′   22   492   1491                  
 
     
       
         
           
               
             
               
                 TABLE APB 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 1.8 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma* M14 
                 0.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.0 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.0 
               
               
                   
                 Testis Pool 
                 0.0 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate Pool 
                 0.0 
               
               
                   
                 Placenta 
                 41.5 
               
               
                   
                 Uterus Pool 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 2.7 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
               
               
                   
                 Ovary 
                 0.0 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca. BT 549 
                 1.7 
               
               
                   
                 Breast ca. T47D 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Breast Pool 
                 0.0 
               
               
                   
                 Trachea 
                 2.8 
               
               
                   
                 Lung 
                 2.9 
               
               
                   
                 Fetal Lung 
                 24.5 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.9 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.0 
               
               
                   
                 Lung ca. A549 
                 0.0 
               
               
                   
                 Lung ca. NCI-H526 
                 6.0 
               
               
                   
                 Lung ca. NCI-H23 
                 0.0 
               
               
                   
                 Lung ca. NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. HOP-62 
                 0.0 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 31.4 
               
               
                   
                 Liver ca. HepG2 
                 7.6 
               
               
                   
                 Kidney Pool 
                 1.7 
               
               
                   
                 Fetal Kidney 
                 100.0 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 6.0 
               
               
                   
                 Bladder 
                 0.0 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.0 
               
               
                   
                 Gastric ca. KATO III 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 4.6 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 24.8 
               
               
                   
                 Colon cancer tissue 
                 1.4 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 0.0 
               
               
                   
                 Small Intestine Pool 
                 0.0 
               
               
                   
                 Stomach Pool 
                 0.0 
               
               
                   
                 Bone Marrow Pool 
                 0.0 
               
               
                   
                 Fetal Heart 
                 0.0 
               
               
                   
                 Heart Pool 
                 0.0 
               
               
                   
                 Lymph Node Pool 
                 0.0 
               
               
                   
                 Fetal Skeletal Muscle 
                 8.0 
               
               
                   
                 Skeletal Muscle Pool 
                 0.0 
               
               
                   
                 Spleen Pool 
                 0.0 
               
               
                   
                 Thymus Pool 
                 3.0 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 0.0 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.0 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 0.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.0 
               
               
                   
                 Brain (Amygdala) Pool 
                 0.0 
               
               
                   
                 Brain (cerebellum) 
                 0.0 
               
               
                   
                 Brain (fetal) 
                 1.7 
               
               
                   
                 Brain (Hippocampus) Pool 
                 4.7 
               
               
                   
                 Cerebral Cortex Pool 
                 0.0 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 0.0 
               
               
                   
                 Brain (Thalamus) Pool 
                 0.0 
               
               
                   
                 Brain (whole) 
                 0.0 
               
               
                   
                 Spinal Cord Pool 
                 22.4 
               
               
                   
                 Adrenal Gland 
                 0.0 
               
               
                   
                 Pituitary gland Pool 
                 0.0 
               
               
                   
                 Salivary Gland 
                 0.0 
               
               
                   
                 Thyroid (female) 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 2.0 
               
               
                   
                 Pancreas Pool 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2957, Run 216861284    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE APC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 0.0 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 1.0 
               
               
                   
                 CC Margin (ODO3866) 
                 0.0 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 13.6 
               
               
                   
                 CC Margin (ODO3868) 
                 1.9 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 0.0 
               
               
                   
                 CC Margin (ODO3920) 
                 0.0 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 0.0 
               
               
                   
                 CC Margin (ODO3921) 
                 1.2 
               
               
                   
                 CC from Partial Hepatectomy (ODO4309) 
                 0.0 
               
               
                   
                 Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 0.0 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 0.0 
               
               
                   
                 Lung Margin (OD04451-02) 
                 0.0 
               
               
                   
                 Normal Prostate 6546-1 
                 1.3 
               
               
                   
                 Prostate Cancer (OD04410) 
                 0.0 
               
               
                   
                 Prostate Margin (OD04410) 
                 2.6 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 0.0 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 0.0 
               
               
                   
                 Normal Lung 061010 
                 0.0 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 0.0 
               
               
                   
                 Muscle Margin (ODO4286) 
                 0.0 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 0.0 
               
               
                   
                 Lung Margin (OD03126) 
                 0.0 
               
               
                   
                 Lung Cancer (OD04404) 
                 0.0 
               
               
                   
                 Lung Margin (OD04404) 
                 0.0 
               
               
                   
                 Lung Cancer (OD04565) 
                 0.0 
               
               
                   
                 Lung Margin (OD04565) 
                 0.0 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 0.0 
               
               
                   
                 Lung Margin (OD04237-02) 
                 0.0 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 0.0 
               
               
                   
                 Liver Margin (ODO4310) 
                 1.4 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.0 
               
               
                   
                 Lung Margin (OD04321) 
                 0.0 
               
               
                   
                 Normal Kidney 
                 85.3 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 6.2 
               
               
                   
                 Kidney Margin (OD04338) 
                 32.3 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 13.5 
               
               
                   
                 Kidney Margin (OD04339) 
                 92.0 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 9.7 
               
               
                   
                 Kidney Margin (OD04340) 
                 87.7 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04348) 
                 100.0 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 50.3 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 58.6 
               
               
                   
                 Kidney Cancer 8120607 
                 0.0 
               
               
                   
                 Kidney Margin 8120608 
                 68.8 
               
               
                   
                 Kidney Cancer 8120613 
                 0.0 
               
               
                   
                 Kidney Margin 8120614 
                 24.3 
               
               
                   
                 Kidney Cancer 9010320 
                 3.4 
               
               
                   
                 Kidney Margin 9010321 
                 85.9 
               
               
                   
                 Normal Uterus 
                 0.0 
               
               
                   
                 Uterus Cancer 064011 
                 1.6 
               
               
                   
                 Normal Thyroid 
                 0.0 
               
               
                   
                 Thyroid Cancer 064010 
                 0.0 
               
               
                   
                 Thyroid Cancer A302152 
                 0.0 
               
               
                   
                 Thyroid Margin A302153 
                 0.0 
               
               
                   
                 Normal Breast 
                 3.3 
               
               
                   
                 Breast Cancer (OD04566) 
                 0.0 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 3.0 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 0.0 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 0.0 
               
               
                   
                 Breast Cancer 064006 
                 0.0 
               
               
                   
                 Breast Cancer 1024 
                 9.5 
               
               
                   
                 Breast Cancer 9100266 
                 3.3 
               
               
                   
                 Breast Margin 9100265 
                 5.4 
               
               
                   
                 Breast Cancer A209073 
                 4.1 
               
               
                   
                 Breast Margin A209073 
                 4.9 
               
               
                   
                 Normal Liver 
                 0.0 
               
               
                   
                 Liver Cancer 064003 
                 0.0 
               
               
                   
                 Liver Cancer 1025 
                 0.0 
               
               
                   
                 Liver Cancer 1026 
                 0.0 
               
               
                   
                 Liver Cancer 6004-T 
                 0.0 
               
               
                   
                 Liver Tissue 6004-N 
                 12.4 
               
               
                   
                 Liver Cancer 6005-T 
                 5.7 
               
               
                   
                 Liver Tissue 6005-N 
                 0.0 
               
               
                   
                 Normal Bladder 
                 0.0 
               
               
                   
                 Bladder Cancer 1023 
                 0.0 
               
               
                   
                 Bladder Cancer A302173 
                 0.0 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 0.0 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 0.0 
               
               
                   
                 Normal Ovary 
                 0.0 
               
               
                   
                 Ovarian Cancer 064008 
                 0.0 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 28.7 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 0.0 
               
               
                   
                 Normal Stomach 
                 0.0 
               
               
                   
                 Gastric Cancer 9060358 
                 0.0 
               
               
                   
                 Stomach Margin 9060359 
                 0.0 
               
               
                   
                 Gastric Cancer 9060395 
                 0.0 
               
               
                   
                 Stomach Margin 9060394 
                 0.0 
               
               
                   
                 Gastric Cancer 9060397 
                 0.0 
               
               
                   
                 Stomach Margin 9060396 
                 0.0 
               
               
                   
                 Gastric Cancer 064005 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2957, Run 170858345    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE APD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.8 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.0 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.0 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
               
               
                   
                 Small airway epithelium none 
                 0.0 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Coronery artery SMC rest 
                 0.0 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Astrocytes rest 
                 0.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Liver cirrhosis 
                 1.7 
               
               
                   
                 Lupus kidney 
                 5.8 
               
               
                   
                 NCI-H292 none 
                 0.0 
               
               
                   
                 NCI-H292 IL-4 
                 0.0 
               
               
                   
                 NCI-H292 IL-9 
                 0.0 
               
               
                   
                 NCI-H292 IL-13 
                 0.0 
               
               
                   
                 NCI-H292 IFN gamma 
                 0.0 
               
               
                   
                 HPAEC none 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 0.0 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast IL-4 
                 0.0 
               
               
                   
                 Lung fibroblast IL-9 
                 0.0 
               
               
                   
                 Lung fibroblast IL-13 
                 0.0 
               
               
                   
                 Lung fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 0.0 
               
               
                   
                 IBD Colitis 2 
                 0.0 
               
               
                   
                 IBD Crohn&#39;s 
                 0.0 
               
               
                   
                 Colon 
                 2.3 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Thymus 
                 100.0 
               
               
                   
                 Kidney 
                 7.6 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2957, Run 164306319    
               
            
           
         
       
     
      General_screening_panel_v1.4 Summary: Ag2957 Expression of this gene was restricted to placenta, fetal kidney and liver. Thus, expression of this gene is useful as a marker to differentiate between these samples and other samples on this panel. This gene shows no or very low expression in the cancer cell lines used in this panel and absence of expression of this gene or its protein product is useful as a diagnostic marker for cancer. This gene encodes a putative claudin. Claudins are components of tight junction strands. This specific pattern of expression indicates that this gene product is involved in the formation of TJ strands in these tissues.  
      Panel 2D Summary: Ag2957 This gene was consistently expressed in the normal kidney samples (CTs=32-33) but not in the adjacent kidney tumors on this panel. Thus, absence of expression of this is useful as a diagnostic marker for kidney cancer. Therapeutic modulation of the function or expression of this gene is useful as a treatment for this cancer.  
      Panel 4D Summary: Ag2957 The expression of this transcript was restricted to the thymus (CT=32.1) but not in T cells. Expression of this transcript is useful as a marker for this tissue.  
      AQ. CG5665308: Ficolin 1 Precursor  
      Expression of gene CG56653-08 was assessed using the primer-probe sets Ag1446, Ag4934 and Ag5886, described in Tables AQA, AQB and AQC. Results of the RTQ-PCR runs are shown in Tables AQD, AQE and AQF.  
               TABLE AQA                          Probe Name Ag1446                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-cgctgtcctgctagtcttgtt-3′   21   37   1492                   Probe   TET-5′-atatcaagaacctgcctgcccaggct-3′-   26   63   1493           TAMRA               Reverse   5′-ccttcacctctggacatgtg-3′   20   94   1494                  
 
     
       
         
           
               
             
               
                 TABLE AQB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag4934 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-cgctgtcctgctagtcttgtt-3′ 
                 21 
                 37 
                 1495 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-atatcaagaacctgcctgcccaggct-3′- 
                 26 
                 63 
                 1496 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-ccttcacctctggacatgtg-3′ 
                 20 
                 94 
                 1497 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AQC 
               
             
            
               
                   
               
               
                   
               
               
                 3Probe Name Ag5886 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-tggcccgttagagaattacc-3′ 
                 20 
                 734 
                 1498 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-acaaaggctcccagtaccagcttgta-3′- 
                 26 
                 695 
                 1499 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-caaatcattcaaggtggctg-3′ 
                 20 
                 661 
                 1500 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AQD 
               
             
            
               
                   
               
               
                   
               
               
                 AI_comprehensive panel_v1.0 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
                 C 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 110967 COPD-F 
                 3.3 
                 1.4 
                 0.0 
               
               
                   
                 110980 COPD-F 
                 4.8 
                 1.0 
                 1.8 
               
               
                   
                 110968 COPD-M 
                 3.5 
                 0.5 
                 1.9 
               
               
                   
                 110977 COPD-M 
                 14.9 
                 6.3 
                 5.4 
               
               
                   
                 110989 Emphysema-F 
                 7.4 
                 2.8 
                 4.4 
               
               
                   
                 110992 Emphysema-F 
                 3.6 
                 2.2 
                 0.2 
               
               
                   
                 110993 Emphysema-F 
                 6.0 
                 1.9 
                 0.4 
               
               
                   
                 110994 Emphysema-F 
                 3.3 
                 1.6 
                 0.2 
               
               
                   
                 110995 Emphysema-F 
                 4.3 
                 2.1 
                 3.3 
               
               
                   
                 110996 Emphysema-F 
                 1.6 
                 1.2 
                 0.7 
               
               
                   
                 110997 Asthma-M 
                 7.6 
                 2.6 
                 0.6 
               
               
                   
                 111001 Asthma-F 
                 15.6 
                 8.3 
                 9.0 
               
               
                   
                 111002 Asthma-F 
                 20.3 
                 6.7 
                 6.4 
               
               
                   
                 111003 Atopic Asthma-F 
                 10.7 
                 3.7 
                 2.6 
               
               
                   
                 111004 Atopic Asthma-F 
                 7.2 
                 0.0 
                 1.7 
               
               
                   
                 111005 Atopic Asthma-F 
                 3.7 
                 1.0 
                 1.8 
               
               
                   
                 111006 Atopic Asthma-F 
                 0.0 
                 0.0 
                 0.3 
               
               
                   
                 111417 Allergy-M 
                 4.1 
                 1.7 
                 1.5 
               
               
                   
                 112347 Allergy-M 
                 0.4 
                 0.0 
                 0.2 
               
               
                   
                 112349 Normal Lung-F 
                 0.5 
                 0.0 
                 0.1 
               
               
                   
                 112357 Normal Lung-F 
                 6.7 
                 2.8 
                 2.2 
               
               
                   
                 112354 Normal Lung-M 
                 0.5 
                 0.4 
                 0.6 
               
               
                   
                 112374 Crohns-F 
                 2.7 
                 0.0 
                 0.4 
               
               
                   
                 112389 Match Control Crohns-F 
                 3.5 
                 1.7 
                 2.4 
               
               
                   
                 112375 Crohns-F 
                 0.0 
                 0.2 
                 1.3 
               
               
                   
                 112732 Match Control Crohns-F 
                 10.2 
                 2.8 
                 3.2 
               
               
                   
                 112725 Crohns-M 
                 11.0 
                 2.4 
                 2.3 
               
               
                   
                 112387 Match Control Crohns-M 
                 4.9 
                 2.3 
                 2.7 
               
               
                   
                 112378 Crohns-M 
                 0.0 
                 0.3 
                 0.2 
               
               
                   
                 112390 Match Control Crohns-M 
                 0.8 
                 0.3 
                 0.6 
               
               
                   
                 112726 Crohns-M 
                 5.1 
                 2.2 
                 2.1 
               
               
                   
                 112731 Match Control Crohns-M 
                 3.1 
                 3.3 
                 2.1 
               
               
                   
                 112380 Ulcer Col-F 
                 1.8 
                 0.5 
                 0.3 
               
               
                   
                 112734 Match Control Ulcer Col-F 
                 40.6 
                 19.1 
                 9.7 
               
               
                   
                 112384 Ulcer Col-F 
                 10.7 
                 3.8 
                 4.8 
               
               
                   
                 112737 Match Control Ulcer Col-F 
                 2.0 
                 1.5 
                 2.0 
               
               
                   
                 112386 Ulcer Col-F 
                 4.0 
                 2.5 
                 4.2 
               
               
                   
                 112738 Match Control Ulcer Col-F 
                 54.3 
                 12.0 
                 7.7 
               
               
                   
                 112381 Ulcer Col-M 
                 0.0 
                 0.0 
                 0.9 
               
               
                   
                 112735 Match Control Ulcer Col-M 
                 3.4 
                 1.8 
                 4.3 
               
               
                   
                 112382 Ulcer Col-M 
                 4.9 
                 1.0 
                 1.8 
               
               
                   
                 112394 Match Control Ulcer Col-M 
                 3.7 
                 1.4 
                 1.9 
               
               
                   
                 112383 Ulcer Col-M 
                 11.2 
                 3.0 
                 3.3 
               
               
                   
                 112736 Match Control Ulcer Col-M 
                 4.6 
                 0.5 
                 0.7 
               
               
                   
                 112423 Psoriasis-F 
                 23.3 
                 11.7 
                 12.9 
               
               
                   
                 112427 Match Control Psoriasis-F 
                 11.0 
                 2.1 
                 4.1 
               
               
                   
                 112418 Psoriasis-M 
                 2.9 
                 1.1 
                 2.6 
               
               
                   
                 112723 Match Control Psoriasis-M 
                 0.9 
                 0.4 
                 0.2 
               
               
                   
                 112419 Psoriasis-M 
                 5.5 
                 2.6 
                 3.9 
               
               
                   
                 112424 Match Control Psoriasis-M 
                 1.8 
                 0.9 
                 1.5 
               
               
                   
                 112420 Psoriasis-M 
                 10.2 
                 3.3 
                 9.2 
               
               
                   
                 112425 Match Control Psoriasis-M 
                 5.6 
                 1.8 
                 2.6 
               
               
                   
                 104689 (MF) OA Bone-Backus 
                 62.0 
                 20.3 
                 19.9 
               
               
                   
                 104690 (MF) Adj “Normal” 
                 23.7 
                 6.0 
                 8.7 
               
               
                   
                 Bone-Backus 
               
               
                   
                 104691 (MF) OA Synovium-Backus 
                 10.2 
                 5.2 
                 3.6 
               
               
                   
                 104692 (BA) OA Cartilage-Backus 
                 0.8 
                 0.0 
                 0.3 
               
               
                   
                 104694 (BA) OA Bone-Backus 
                 49.0 
                 16.0 
                 11.3 
               
               
                   
                 104695 (BA) Adj “Normal” 
                 19.9 
                 7.9 
                 5.1 
               
               
                   
                 Bone-Backus 
               
               
                   
                 104696 (BA) OA Synovium-Backus 
                 16.3 
                 5.2 
                 5.1 
               
               
                   
                 104700 (SS) OA Bone-Backus 
                 100.0 
                 100.0 
                 100.0 
               
               
                   
                 104701 (SS) Adj “Normal” 
                 29.7 
                 7.0 
                 8.7 
               
               
                   
                 Bone-Backus 
               
               
                   
                 104702 (SS) OA Synovium-Backus 
                 27.7 
                 9.3 
                 11.0 
               
               
                   
                 117093 OA Cartilage Rep7 
                 3.3 
                 0.0 
                 0.8 
               
               
                   
                 112672 OA Bone5 
                 23.3 
                 5.1 
                 10.2 
               
               
                   
                 112673 OA Synovium5 
                 7.1 
                 2.6 
                 2.9 
               
               
                   
                 112674 OA Synovial Fluid cells5 
                 9.1 
                 3.7 
                 4.3 
               
               
                   
                 117100 OA Cartilage Rep14 
                 2.4 
                 1.3 
                 1.5 
               
               
                   
                 112756 OA Bone9 
                 3.9 
                 0.7 
                 0.7 
               
               
                   
                 112757 OA Synovium9 
                 2.3 
                 2.7 
                 0.9 
               
               
                   
                 112758 OA Synovial Fluid Cells9 
                 14.3 
                 3.6 
                 7.3 
               
               
                   
                 117125 RA Cartilage Rep2 
                 3.6 
                 1.0 
                 1.6 
               
               
                   
                 113492 Bone2 RA 
                 45.4 
                 11.2 
                 28.7 
               
               
                   
                 113493 Synovium2 RA 
                 13.9 
                 3.5 
                 11.8 
               
               
                   
                 113494 Syn Fluid Cells RA 
                 29.7 
                 10.7 
                 16.6 
               
               
                   
                 113499 Cartilage4 RA 
                 14.9 
                 6.8 
                 10.7 
               
               
                   
                 113500 Bone4 RA 
                 16.0 
                 5.4 
                 11.8 
               
               
                   
                 113501 Synovium4 RA 
                 11.7 
                 5.2 
                 13.3 
               
               
                   
                 113502 Syn Fluid Cells4 RA 
                 7.7 
                 4.2 
                 6.6 
               
               
                   
                 113495 Cartilage3 RA 
                 26.6 
                 12.5 
                 16.5 
               
               
                   
                 113496 Bone3 RA 
                 34.6 
                 8.5 
                 16.3 
               
               
                   
                 113497 Synovium3 RA 
                 15.4 
                 6.4 
                 9.0 
               
               
                   
                 113498 Syn Fluid Cells3 RA 
                 33.7 
                 12.8 
                 23.3 
               
               
                   
                 117106 Normal Cartilage Rep20 
                 0.5 
                 0.6 
                 0.9 
               
               
                   
                 113663 Bone3 Normal 
                 0.0 
                 0.3 
                 0.2 
               
               
                   
                 113664 Synovium3 Normal 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 113665 Syn Fluid Cells3 Normal 
                 0.8 
                 0.0 
                 0.0 
               
               
                   
                 117107 Normal Cartilage Rep22 
                 2.4 
                 1.4 
                 2.1 
               
               
                   
                 113667 Bone4 Normal 
                 0.8 
                 0.5 
                 0.7 
               
               
                   
                 113668 Synovium4 Normal 
                 0.6 
                 0.9 
                 0.2 
               
               
                   
                 113669 Syn Fluid Cells4 Normal 
                 2.4 
                 0.4 
                 1.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1446, Run 211195015    
               
               
                   
                   Column B - Rel. Exp. (%) Ag1446, Run 212650184    
               
               
                   
                   Column C - Rel. Exp. (%) Ag5886, Run 256261777    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AQE 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.5 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Adipose 
                 48.6 
                 48.6 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* M14 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 4.8 
                 0.0 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.0 
                 0.0 
               
               
                   
                 Testis Pool 
                 1.4 
                 1.3 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
                 0.0 
               
               
                   
                 Prostate Pool 
                 9.3 
                 5.6 
               
               
                   
                 Placenta 
                 26.8 
                 15.1 
               
               
                   
                 Uterus Pool 
                 12.4 
                 4.9 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
                 0.0 
               
               
                   
                 Ovary 
                 4.6 
                 6.3 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. BT 549 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. T47D 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
                 0.0 
               
               
                   
                 Breast Pool 
                 25.3 
                 15.9 
               
               
                   
                 Trachea 
                 24.3 
                 10.7 
               
               
                   
                 Lung 
                 0.7 
                 0.7 
               
               
                   
                 Fetal Lung 
                 100.0 
                 100.0 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. A549 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. NCI-H526 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. NCI-H460 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. HOP-62 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
                 0.0 
               
               
                   
                 Liver 
                 2.2 
                 3.3 
               
               
                   
                 Fetal Liver 
                 28.5 
                 12.6 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Pool 
                 18.6 
                 7.9 
               
               
                   
                 Fetal Kidney 
                 7.5 
                 9.5 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
                 0.0 
               
               
                   
                 Bladder 
                 6.4 
                 4.0 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.0 
                 0.0 
               
               
                   
                 Gastric ca. KATO III 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
                 0.0 
               
               
                   
                 Colon cancer tissue 
                 35.6 
                 14.9 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
                 0.0 
               
               
                   
                 Colon Pool 
                 68.8 
                 34.4 
               
               
                   
                 Small Intestine Pool 
                 9.4 
                 3.8 
               
               
                   
                 Stomach Pool 
                 7.5 
                 4.8 
               
               
                   
                 Bone Marrow Pool 
                 8.5 
                 8.4 
               
               
                   
                 Fetal Heart 
                 5.4 
                 13.2 
               
               
                   
                 Heart Pool 
                 9.9 
                 3.4 
               
               
                   
                 Lymph Node Pool 
                 8.9 
                 9.5 
               
               
                   
                 Fetal Skeletal Muscle 
                 7.2 
                 12.6 
               
               
                   
                 Skeletal Muscle Pool 
                 17.4 
                 5.2 
               
               
                   
                 Spleen Pool 
                 84.7 
                 60.7 
               
               
                   
                 Thymus Pool 
                 16.8 
                 6.0 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.0 
                 0.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 0.0 
                 0.0 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.0 
                 0.0 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.0 
                 0.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 0.0 
                 0.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.0 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.0 
                 0.1 
               
               
                   
                 Brain (Amygdala) Pool 
                 1.8 
                 0.2 
               
               
                   
                 Brain (cerebellum) 
                 1.4 
                 1.1 
               
               
                   
                 Brain (fetal) 
                 3.6 
                 1.1 
               
               
                   
                 Brain (Hippocampus) Pool 
                 2.0 
                 0.8 
               
               
                   
                 Cerebral Cortex Pool 
                 1.9 
                 0.5 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 1.7 
                 0.9 
               
               
                   
                 Brain (Thalamus) Pool 
                 1.4 
                 0.9 
               
               
                   
                 Brain (whole) 
                 3.7 
                 2.7 
               
               
                   
                 Spinal Cord Pool 
                 3.1 
                 0.6 
               
               
                   
                 Adrenal Gland 
                 6.0 
                 4.1 
               
               
                   
                 Pituitary gland Pool 
                 0.7 
                 0.7 
               
               
                   
                 Salivary Gland 
                 5.9 
                 2.7 
               
               
                   
                 Thyroid (female) 
                 15.0 
                 5.5 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.0 
                 0.0 
               
               
                   
                 Pancreas Pool 
                 27.9 
                 9.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag4934, Run 228843453    
               
               
                   
                   Column B - Rel. Exp. (%) Ag5886, Run 247756990    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AQF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Secondary Th1 act 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 act 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 act 
                 0.0 
                 0.0 
               
               
                 Secondary Th1 rest 
                 0.0 
                 0.0 
               
               
                 Secondary Th2 rest 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 rest 
                 0.0 
                 0.0 
               
               
                 Primary Th1 act 
                 0.0 
                 0.0 
               
               
                 Primary Th2 act 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 act 
                 0.0 
                 0.0 
               
               
                 Primary Th1 rest 
                 0.0 
                 0.0 
               
               
                 Primary Th2 rest 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 rest 
                 0.0 
                 0.0 
               
               
                 CD45RA CD4 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD45RO CD4 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte rest 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                 CD4 lymphocyte none 
                 0.5 
                 0.3 
               
               
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
                 0.0 
               
               
                 LAK cells rest 
                 6.9 
                 21.5 
               
               
                 LAK cells IL-2 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-12 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IFN gamma 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 + IL-18 
                 0.0 
                 0.0 
               
               
                 LAK cells PMA/ionomycin 
                 8.2 
                 66.0 
               
               
                 NK Cells IL-2 rest 
                 0.0 
                 0.0 
               
               
                 Two Way MLR 3 day 
                 1.0 
                 1.7 
               
               
                 Two Way MLR 5 day 
                 0.1 
                 0.0 
               
               
                 Two Way MLR 7 day 
                 0.0 
                 0.0 
               
               
                 PBMC rest 
                 19.2 
                 24.0 
               
               
                 PBMC PWM 
                 0.0 
                 0.0 
               
               
                 PBMC PHA-L 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) none 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
               
               
                 B lymphocytes PWM 
                 0.0 
                 0.0 
               
               
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 0.1 
               
               
                 EOL-1 dbcAMP 
                 3.5 
                 14.9 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.5 
                 0.2 
               
               
                 Dendritic cells none 
                 1.0 
                 4.5 
               
               
                 Dendritic cells LPS 
                 0.1 
                 0.0 
               
               
                 Dendritic cells anti-CD40 
                 0.6 
                 0.1 
               
               
                 Monocytes rest 
                 100.0 
                 100.0 
               
               
                 Monocytes LPS 
                 4.8 
                 15.6 
               
               
                 Macrophages rest 
                 4.1 
                 5.0 
               
               
                 Macrophages LPS 
                 1.8 
                 2.3 
               
               
                 HUVEC none 
                 0.0 
                 0.0 
               
               
                 HUVEC starved 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-1beta 
                 0.0 
                 0.0 
               
               
                 HUVEC IFN gamma 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
                 0.0 
               
               
                 HUVEC TNF alpha + IL4 
                 0.0 
                 0.0 
               
               
                 HUVEC IL-11 
                 0.0 
                 0.0 
               
               
                 Lung Microvascular EC none 
                 0.0 
                 0.0 
               
               
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Microvascular Dermal EC none 
                 0.0 
                 0.0 
               
               
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
                 0.0 
               
               
                 Small airway epithelium none 
                 0.0 
                 0.0 
               
               
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Coronery artery SMC rest 
                 0.0 
                 0.0 
               
               
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Astrocytes rest 
                 0.0 
                 0.0 
               
               
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) rest 
                 0.0 
                 0.0 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) none 
                 0.0 
                 0.0 
               
               
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                 Liver cirrhosis 
                 0.2 
                 0.8 
               
               
                 NCI-H292 none 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IL-4 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IL-9 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IL-13 
                 0.0 
                 0.0 
               
               
                 NCI-H292 IFN gamma 
                 0.0 
                 0.0 
               
               
                 HPAEC none 
                 0.0 
                 0.0 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast none 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-4 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-9 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IL-13 
                 0.0 
                 0.0 
               
               
                 Lung fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 rest 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
                 0.0 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.1 
                 0.0 
               
               
                 Dermal fibroblast IFN gamma 
                 0.1 
                 0.0 
               
               
                 Dermal fibroblast IL-4 
                 0.3 
                 0.0 
               
               
                 Dermal Fibroblasts rest 
                 0.1 
                 0.0 
               
               
                 Neutrophils TNFa + LPS 
                 1.8 
                 14.0 
               
               
                 Neutrophils rest 
                 3.8 
                 47.3 
               
               
                 Colon 
                 0.0 
                 0.0 
               
               
                 Lung 
                 0.3 
                 0.2 
               
               
                 Thymus 
                 0.2 
                 0.1 
               
               
                 Kidney 
                 0.1 
                 0.2 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag4934, Run 223597255    
               
               
                   Column B - Rel. Exp. (%) Ag5886, Run 256523048    
               
            
           
         
       
     
      AI_comprehensive panel_v1.0 Summary: Ag1446/Ag5886 Highest expression of this gene was seen in a bone sample from an OA patient (CTs=27-30.4). Moderate to high expression of this gene wass mainly seen in bone, synovium, synovial fluid and cartilage of OA and RA patients. Expression of this gene was low to undetectable in normal bone. Moderate to low expression was also found in colon, asthma, atopic asthma, emphysema, COPD and psoriasis samples. Ficolins are multimeric lectins that are capable of binding to bacteria and extracellular matrix proteins [Ohashi T. J Biol Chem 1997 May 30;272(22):14220-6]. Ficolin has been reported to function as a monocyte cell surface molecule that is important for binding to bacteria, elastin and for monocyte adhesion [Lu J, Immunobiology 1998 August;199(2):190-9]. This expression proves that ficolin is useful in alleviating inflammation in joints and other sites of inflammation. This gene functions as a protein therapeutic to reduce inflammation in osteoarthritis and rheumatoid arthritis. Ficolin also a role in the inflammation of joints in patients suffering from osteoarthritis (OA) and/or rheumatoid arthritis (RA). Antibodies against proteins encoded by this gene are useful for the prevention of tissue destruction mediated by ficolin activity during osteoarthritis and arthritis.  
      General_screening_panel_v1.5 Summary: Ag4934/Ag5886 Highest expression of this gene was detected in the fetal lung (CTs=27-31.5). Expression of this gene was also higher in fetal lung and fetal liver (CTs=27-33) than in their adult counterparts (CTs=32-38). Expression of this gene is useful as a marker to distinguish fetal from adult lung and liver. The relative overexpression of this gene in fetal tissue shows that the protein product enhances lung and liver growth or development in the fetus and also acts in a regenerative capacity in the adult. Therapeutic modulation of the protein encoded by this gene is useful in treatment of liver related diseases. Low but significant levels of expression was detected in tissues with metabolic/endocrine functions including adipose, heart, skeletal muscle, thyroid, pancreas and gastrointestinal tracts. Modulation of this gene or gene product is a treatment for metabolic or endocrine disease including obesity and Types 1 and 2 diabetes.  
      Low expression of this gene was also seen in some regions of central nervous system including whole and fetal brain, cerebellum, hipocampus, substantia nigra, thalamus and spinal cord. Therapeutic modulation of this gene or gene product is useful in the treatment of central nervous system disorders such as Alzheimer&#39;s disease, Parkinson&#39;s disease, epilepsy, multiple sclerosis, schizophrenia and depression.  
      Panel 4.1D Summary: Ag4934/Ag5886 This gene was highly and selectively expressed in resting monocytes and to a lesser extent in macrophages and granulocytes (neutrophils and EOL cell line). This gene encodes a putative ficolin 1 precursor. Ficolin functions as a monocyte cell surface molecule that is important for binding to bacteria, elastin and monocyte adhesion. Protein therapeutics, antibodies, or small molecules designed with the protein encoded by this transcript are useful as opsinins to target and eliminate bacteria by complement-mediated destruction. These proteins are also important for the treatment of bacterial septicemia. In addition, ficolins may have the ability to bind to elastins. Elastins are functionally important for lung alveolar development and inactivation of these proteins can lead to emphysema-like disease. Therefore, antibodies, small molecules or protein therapeutics that target this gene or its protein product are useful for the prevention of tissue destruction mediated by ficolin activity during emphysema, asthma and arthritis.  
      AR. CG56806-01: Heparan Sulfate 6-Sulfotransferase 3 Like Gene  
      Expression of gene CG56806-01 was assessed using the primer-probe set Ag3024, described in Table ARA. Results of the RTQ-PCR runs are shown in Tables ARB, ARC, ARD, ARE and ARF.  
               TABLE ARA                          Probe Name Ag3024                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-ggtgggctgctataacttgact-3′   22   1033   1501                   Probe   TET-5′-tgaaagaaacaccatcctgttgcaga-3′-   26   1069   1502           TAMRA               Reverse   5′-tgttcttcaggttgttctttgc-3′   22   1097   1503                  
 
     
       
         
           
               
             
               
                 TABLE ARB 
               
             
            
               
                   
               
               
                   
               
               
                 AI_comprehensive panel_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 110967 COPD-F 
                 10.6 
               
               
                   
                 110980 COPD-F 
                 9.5 
               
               
                   
                 110968 COPD-M 
                 10.8 
               
               
                   
                 110977 COPD-M 
                 16.7 
               
               
                   
                 110989 Emphysema-F 
                 44.8 
               
               
                   
                 110992 Emphysema-F 
                 3.8 
               
               
                   
                 110993 Emphysema-F 
                 2.6 
               
               
                   
                 110994 Emphysema-F 
                 1.0 
               
               
                   
                 110995 Emphysema-F 
                 9.0 
               
               
                   
                 110996 Emphysema-F 
                 1.3 
               
               
                   
                 110997 Asthma-M 
                 1.0 
               
               
                   
                 111001 Asthma-F 
                 33.4 
               
               
                   
                 111002 Asthma-F 
                 37.9 
               
               
                   
                 111003 Atopic Asthma-F 
                 41.5 
               
               
                   
                 111004 Atopic Asthma-F 
                 21.2 
               
               
                   
                 111005 Atopic Asthma-F 
                 39.0 
               
               
                   
                 111006 Atopic Asthma-F 
                 8.5 
               
               
                   
                 111417 Allergy-M 
                 26.6 
               
               
                   
                 112347 Allergy-M 
                 8.6 
               
               
                   
                 112349 Normal Lung-F 
                 9.2 
               
               
                   
                 112357 Normal Lung-F 
                 0.6 
               
               
                   
                 112354 Normal Lung-M 
                 1.3 
               
               
                   
                 112374 Crohns-F 
                 4.0 
               
               
                   
                 112389 Match Control Crohns-F 
                 1.3 
               
               
                   
                 112375 Crohns-F 
                 4.5 
               
               
                   
                 112732 Match Control Crohns-F 
                 0.0 
               
               
                   
                 112725 Crohns-M 
                 9.9 
               
               
                   
                 112387 Match Control Crohns-M 
                 15.3 
               
               
                   
                 112378 Crohns-M 
                 9.7 
               
               
                   
                 112390 Match Control Crohns-M 
                 23.7 
               
               
                   
                 112726 Crohns-M 
                 2.9 
               
               
                   
                 112731 Match Control Crohns-M 
                 1.4 
               
               
                   
                 112380 Ulcer Col-F 
                 8.7 
               
               
                   
                 112734 Match Control Ulcer Col-F 
                 0.7 
               
               
                   
                 112384 Ulcer Col-F 
                 25.3 
               
               
                   
                 112737 Match Control Ulcer Col-F 
                 3.0 
               
               
                   
                 112386 Ulcer Col-F 
                 3.3 
               
               
                   
                 112738 Match Control Ulcer Col-F 
                 0.6 
               
               
                   
                 112381 Ulcer Col-M 
                 1.8 
               
               
                   
                 112735 Match Control Ulcer Col-M 
                 32.8 
               
               
                   
                 112382 Ulcer Col-M 
                 1.5 
               
               
                   
                 112394 Match Control Ulcer Col-M 
                 1.8 
               
               
                   
                 112383 Ulcer Col-M 
                 6.3 
               
               
                   
                 112736 Match Control Ulcer Col-M 
                 1.1 
               
               
                   
                 112423 Psoriasis-F 
                 12.7 
               
               
                   
                 112427 Match Control Psoriasis-F 
                 37.1 
               
               
                   
                 112418 Psoriasis-M 
                 6.1 
               
               
                   
                 112723 Match Control Psoriasis-M 
                 0.0 
               
               
                   
                 112419 Psoriasis-M 
                 16.6 
               
               
                   
                 112424 Match Control Psoriasis-M 
                 17.8 
               
               
                   
                 112420 Psoriasis-M 
                 100.0 
               
               
                   
                 112425 Match Control Psoriasis-M 
                 26.2 
               
               
                   
                 104689 (MF) OA Bone-Backus 
                 0.0 
               
               
                   
                 104690 (MF) Adj “Normal” Bone-Backus 
                 0.4 
               
               
                   
                 104691 (MF) OA Synovium-Backus 
                 3.0 
               
               
                   
                 104692 (BA) OA Cartilage-Backus 
                 1.0 
               
               
                   
                 104694 (BA) OA Bone-Backus 
                 0.0 
               
               
                   
                 104695 (BA) Adj “Normal” Bone-Backus 
                 0.6 
               
               
                   
                 104696 (BA) OA Synovium-Backus 
                 0.5 
               
               
                   
                 104700 (SS) OA Bone-Backus 
                 0.2 
               
               
                   
                 104701 (SS) Adj “Normal” Bone-Backus 
                 0.3 
               
               
                   
                 104702 (SS) OA Synovium-Backus 
                 4.5 
               
               
                   
                 117093 OA Cartilage Rep7 
                 42.0 
               
               
                   
                 112672 OA Bone5 
                 18.4 
               
               
                   
                 112673 OA Synovium5 
                 8.0 
               
               
                   
                 112674 OA Synovial Fluid cells5 
                 2.4 
               
               
                   
                 117100 OA Cartilage Rep14 
                 5.5 
               
               
                   
                 112756 OA Bone9 
                 3.5 
               
               
                   
                 112757 OA Synovium9 
                 2.1 
               
               
                   
                 112758 OA Synovial Fluid Cells9 
                 11.9 
               
               
                   
                 117125 RA Cartilage Rep2 
                 2.5 
               
               
                   
                 113492 Bone2 RA 
                 1.7 
               
               
                   
                 113493 Synovium2 RA 
                 0.0 
               
               
                   
                 113494 Syn Fluid Cells RA 
                 1.6 
               
               
                   
                 113499 Cartilage4 RA 
                 0.4 
               
               
                   
                 113500 Bone4 RA 
                 1.3 
               
               
                   
                 113501 Synovium4 RA 
                 0.0 
               
               
                   
                 113502 Syn Fluid Cells4 RA 
                 0.2 
               
               
                   
                 113495 Cartilage3 RA 
                 0.2 
               
               
                   
                 113496 Bone3 RA 
                 0.6 
               
               
                   
                 113497 Synovium3 RA 
                 0.9 
               
               
                   
                 113498 Syn Fluid Cells3 RA 
                 0.6 
               
               
                   
                 117106 Normal Cartilage Rep20 
                 14.1 
               
               
                   
                 113663 Bone3 Normal 
                 8.5 
               
               
                   
                 113664 Synovium3 Normal 
                 4.0 
               
               
                   
                 113665 Syn Fluid Cells3 Normal 
                 5.7 
               
               
                   
                 117107 Normal Cartilage Rep22 
                 13.8 
               
               
                   
                 113667 Bone4 Normal 
                 17.2 
               
               
                   
                 113668 Synovium4 Normal 
                 14.7 
               
               
                   
                 113669 Syn Fluid Cells4 Normal 
                 7.6 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3024, Run 248122026    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ARC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 0.4 
               
               
                   
                 Pancreas 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
               
               
                   
                 Adrenal gland 
                 2.6 
               
               
                   
                 Thyroid 
                 0.7 
               
               
                   
                 Salivary gland 
                 0.0 
               
               
                   
                 Pituitary gland 
                 2.0 
               
               
                   
                 Brain (fetal) 
                 11.0 
               
               
                   
                 Brain (whole) 
                 54.7 
               
               
                   
                 Brain (amygdala) 
                 27.2 
               
               
                   
                 Brain (cerebellum) 
                 12.9 
               
               
                   
                 Brain (hippocampus) 
                 36.3 
               
               
                   
                 Brain (substantia nigra) 
                 5.7 
               
               
                   
                 Brain (thalamus) 
                 64.2 
               
               
                   
                 Cerebral Cortex 
                 100.0 
               
               
                   
                 Spinal cord 
                 3.8 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 14.7 
               
               
                   
                 astrocytoma SW1783 
                 1.7 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.0 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 6.0 
               
               
                   
                 glioma SNB-19 
                 0.6 
               
               
                   
                 glioma U251 
                 0.0 
               
               
                   
                 glioma SF-295 
                 0.0 
               
               
                   
                 Heart (fetal) 
                 0.0 
               
               
                   
                 Heart 
                 0.6 
               
               
                   
                 Skeletal muscle (fetal) 
                 1.9 
               
               
                   
                 Skeletal muscle 
                 0.4 
               
               
                   
                 Bone marrow 
                 0.0 
               
               
                   
                 Thymus 
                 0.0 
               
               
                   
                 Spleen 
                 0.7 
               
               
                   
                 Lymph node 
                 0.0 
               
               
                   
                 Colorectal 
                 0.8 
               
               
                   
                 Stomach 
                 6.9 
               
               
                   
                 Small intestine 
                 1.4 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 1.0 
               
               
                   
                 Colon ca. HCC-2998 
                 0.0 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.4 
               
               
                   
                 Bladder 
                 0.7 
               
               
                   
                 Trachea 
                 2.4 
               
               
                   
                 Kidney 
                 0.6 
               
               
                   
                 Kidney (fetal) 
                 0.2 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 2.4 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Liver 
                 0.7 
               
               
                   
                 Liver (fetal) 
                 0.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Lung (fetal) 
                 0.0 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.0 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.2 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.6 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 2.1 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
               
               
                   
                 Mammary gland 
                 0.4 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 11.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.9 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 2.3 
               
               
                   
                 Breast ca. BT-549 
                 1.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Ovary 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.2 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.0 
               
               
                   
                 Uterus 
                 2.2 
               
               
                   
                 Placenta 
                 0.0 
               
               
                   
                 Prostate 
                 0.4 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 0.0 
               
               
                   
                 Testis 
                 1.7 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 0.2 
               
               
                   
                 Melanoma M14 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
               
               
                   
                 Adipose 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3024, Run 165517896    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ARD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 4.7 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 5.0 
               
               
                   
                 CC Margin (ODO3866) 
                 3.1 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 0.0 
               
               
                   
                 CC Margin (ODO3868) 
                 0.3 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 0.0 
               
               
                   
                 CC Margin (ODO3920) 
                 0.5 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 3.1 
               
               
                   
                 CC Margin (ODO3921) 
                 2.1 
               
               
                   
                 CC from Partial Hepatectomy (ODO4309) Mets 
                 1.8 
               
               
                   
                 Liver Margin (ODO4309) 
                 0.0 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 0.0 
               
               
                   
                 Lung Margin (OD04451-02) 
                 0.0 
               
               
                   
                 Normal Prostate 6546-1 
                 3.7 
               
               
                   
                 Prostate Cancer (OD04410) 
                 5.2 
               
               
                   
                 Prostate Margin (OD04410) 
                 5.4 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 11.9 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 6.4 
               
               
                   
                 Normal Lung 061010 
                 0.0 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 0.6 
               
               
                   
                 Muscle Margin (ODO4286) 
                 1.0 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 0.0 
               
               
                   
                 Lung Margin (OD03126) 
                 1.6 
               
               
                   
                 Lung Cancer (OD04404) 
                 0.0 
               
               
                   
                 Lung Margin (OD04404) 
                 1.0 
               
               
                   
                 Lung Cancer (OD04565) 
                 0.0 
               
               
                   
                 Lung Margin (OD04565) 
                 0.0 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 8.4 
               
               
                   
                 Lung Margin (OD04237-02) 
                 0.0 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 2.5 
               
               
                   
                 Liver Margin (ODO4310) 
                 0.0 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.4 
               
               
                   
                 Lung Margin (OD04321) 
                 0.5 
               
               
                   
                 Normal Kidney 
                 23.7 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 1.2 
               
               
                   
                 Kidney Margin (OD04338) 
                 10.6 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04339) 
                 7.7 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 9.3 
               
               
                   
                 Kidney Margin (OD04340) 
                 17.2 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 2.3 
               
               
                   
                 Kidney Margin (OD04348) 
                 5.1 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 2.8 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 17.8 
               
               
                   
                 Kidney Cancer 8120607 
                 1.7 
               
               
                   
                 Kidney Margin 8120608 
                 1.3 
               
               
                   
                 Kidney Cancer 8120613 
                 100.0 
               
               
                   
                 Kidney Margin 8120614 
                 5.3 
               
               
                   
                 Kidney Cancer 9010320 
                 0.8 
               
               
                   
                 Kidney Margin 9010321 
                 6.3 
               
               
                   
                 Normal Uterus 
                 0.7 
               
               
                   
                 Uterus Cancer 064011 
                 9.4 
               
               
                   
                 Normal Thyroid 
                 5.7 
               
               
                   
                 Thyroid Cancer 064010 
                 0.3 
               
               
                   
                 Thyroid Cancer A302152 
                 2.0 
               
               
                   
                 Thyroid Margin A302153 
                 23.5 
               
               
                   
                 Normal Breast 
                 7.9 
               
               
                   
                 Breast Cancer (OD04566) 
                 7.4 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 0.0 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 3.6 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 3.8 
               
               
                   
                 Breast Cancer 064006 
                 7.1 
               
               
                   
                 Breast Cancer 1024 
                 6.2 
               
               
                   
                 Breast Cancer 9100266 
                 27.7 
               
               
                   
                 Breast Margin 9100265 
                 4.3 
               
               
                   
                 Breast Cancer A209073 
                 30.8 
               
               
                   
                 Breast Margin A209073 
                 3.0 
               
               
                   
                 Normal Liver 
                 1.3 
               
               
                   
                 Liver Cancer 064003 
                 0.4 
               
               
                   
                 Liver Cancer 1025 
                 0.0 
               
               
                   
                 Liver Cancer 1026 
                 0.0 
               
               
                   
                 Liver Cancer 6004-T 
                 0.0 
               
               
                   
                 Liver Tissue 6004-N 
                 1.1 
               
               
                   
                 Liver Cancer 6005-T 
                 0.0 
               
               
                   
                 Liver Tissue 6005-N 
                 0.0 
               
               
                   
                 Normal Bladder 
                 2.8 
               
               
                   
                 Bladder Cancer 1023 
                 0.0 
               
               
                   
                 Bladder Cancer A302173 
                 2.2 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 0.7 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 0.4 
               
               
                   
                 Normal Ovary 
                 0.0 
               
               
                   
                 Ovarian Cancer 064008 
                 1.4 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 0.0 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 3.3 
               
               
                   
                 Normal Stomach 
                 17.8 
               
               
                   
                 Gastric Cancer 9060358 
                 1.0 
               
               
                   
                 Stomach Margin 9060359 
                 13.6 
               
               
                   
                 Gastric Cancer 9060395 
                 7.5 
               
               
                   
                 Stomach Margin 9060394 
                 4.1 
               
               
                   
                 Gastric Cancer 9060397 
                 13.4 
               
               
                   
                 Stomach Margin 9060396 
                 6.7 
               
               
                   
                 Gastric Cancer 064005 
                 1.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3024, Run 163577593    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ARE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Daoy- Medulloblastoma 
                 1.6 
               
               
                   
                 TE671- Medulloblastoma 
                 0.0 
               
               
                   
                 D283 Med- Medulloblastoma 
                 0.0 
               
               
                   
                 PFSK-1- Primitive Neuroectodermal 
                 0.0 
               
               
                   
                 XF-498- CNS 
                 0.6 
               
               
                   
                 SNB-78- Glioma 
                 0.0 
               
               
                   
                 SF-268- Glioblastoma 
                 0.4 
               
               
                   
                 T98G- Glioblastoma 
                 14.1 
               
               
                   
                 SK-N-SH- Neuroblastoma (metastasis) 
                 0.2 
               
               
                   
                 SF-295- Glioblastoma 
                 0.4 
               
               
                   
                 Cerebellum 
                 15.3 
               
               
                   
                 Cerebellum 
                 5.4 
               
               
                   
                 NCI-H292- Mucoepidermoid lung carcinoma 
                 0.0 
               
               
                   
                 DMS-114- Small cell lung cancer 
                 0.0 
               
               
                   
                 DMS-79- Small cell lung cancer 
                 3.3 
               
               
                   
                 NCI-H146- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H526- Small cell lung cancer 
                 57.4 
               
               
                   
                 NCI-N417- Small cell lung cancer 
                 14.4 
               
               
                   
                 NCI-H82- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H157- Squamous cell lung cancer 
                 0.0 
               
               
                   
                 (metastasis) 
               
               
                   
                 NCI-H1155- Large cell lung cancer 
                 2.9 
               
               
                   
                 NCI-H1299- Large cell lung cancer 
                 0.3 
               
               
                   
                 NCI-H727- Lung carcinoid 
                 15.9 
               
               
                   
                 NCI-UMC-11- Lung carcinoid 
                 1.2 
               
               
                   
                 LX-1- Small cell lung cancer 
                 0.0 
               
               
                   
                 Colo-205- Colon cancer 
                 0.0 
               
               
                   
                 KM12- Colon cancer 
                 0.0 
               
               
                   
                 KM20L2- Colon cancer 
                 0.0 
               
               
                   
                 NCI-H716- Colon cancer 
                 100.0 
               
               
                   
                 SW-48- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW1116- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 LS 174T- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-948- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-480- Colon adenocarcinoma 
                 1.1 
               
               
                   
                 NCI-SNU-5- Gastric carcinoma 
                 0.0 
               
               
                   
                 KATO III- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-16- Gastric carcinoma 
                 0.4 
               
               
                   
                 NCI-SNU-1- Gastric carcinoma 
                 0.0 
               
               
                   
                 RF-1- Gastric adenocarcinoma 
                 0.0 
               
               
                   
                 RF-48- Gastric adenocarcinoma 
                 0.0 
               
               
                   
                 MKN-45- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-N87- Gastric carcinoma 
                 0.0 
               
               
                   
                 OVCAR-5- Ovarian carcinoma 
                 0.0 
               
               
                   
                 RL95-2- Uterine carcinoma 
                 0.2 
               
               
                   
                 HelaS3- Cervical adenocarcinoma 
                 0.0 
               
               
                   
                 Ca Ski- Cervical epidermoid carcinoma 
                 0.0 
               
               
                   
                 (metastasis) 
               
               
                   
                 ES-2- Ovarian clear cell carcinoma 
                 0.3 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 0.0 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 0.0 
               
               
                   
                 MEG-01- Chronic myelogenous leukemia 
                 0.6 
               
               
                   
                 (megokaryoblast) 
               
               
                   
                 Raji- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 Daudi- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 U266- B-cell plasmacytoma 
                 0.0 
               
               
                   
                 CA46- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 0.0 
               
               
                   
                 JM1- pre-B-cell lymphoma 
                 0.0 
               
               
                   
                 Jurkat- T cell leukemia 
                 0.2 
               
               
                   
                 TF-1- Erythroleukemia 
                 0.0 
               
               
                   
                 HUT 78- T-cell lymphoma 
                 0.0 
               
               
                   
                 U937- Histiocytic lymphoma 
                 0.0 
               
               
                   
                 KU-812- Myelogenous leukemia 
                 0.0 
               
               
                   
                 769-P- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 Caki-2- Clear cell renal carcinoma 
                 32.8 
               
               
                   
                 SW 839- Clear cell renal carcinoma 
                 0.2 
               
               
                   
                 Rhabdoid kidney tumor 
                 0.0 
               
               
                   
                 Hs766T- Pancreatic carcinoma (LN 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 CAPAN-1- Pancreatic adenocarcinoma (liver 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 SU86.86- Pancreatic carcinoma (liver 
                 1.5 
               
               
                   
                 metastasis) 
               
               
                   
                 BxPC-3- Pancreatic adenocarcinoma 
                 0.0 
               
               
                   
                 HPAC- Pancreatic adenocarcinoma 
                 0.3 
               
               
                   
                 MIA PaCa-2- Pancreatic carcinoma 
                 0.0 
               
               
                   
                 CFPAC-1- Pancreatic ductal adenocarcinoma 
                 0.0 
               
               
                   
                 PANC-1- Pancreatic epithelioid ductal 
                 0.8 
               
               
                   
                 carcinoma 
               
               
                   
                 T24- Bladder carcinma (transitional cell) 
                 0.0 
               
               
                   
                 5637- Bladder carcinoma 
                 0.0 
               
               
                   
                 HT-1197- Bladder carcinoma 
                 0.0 
               
               
                   
                 UM-UC-3- Bladder carcinma (transitional cell) 
                 0.0 
               
               
                   
                 A204- Rhabdomyosarcoma 
                 0.0 
               
               
                   
                 HT-1080- Fibrosarcoma 
                 0.3 
               
               
                   
                 MG-63- Osteosarcoma 
                 0.0 
               
               
                   
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 4.6 
               
               
                   
                 SJRH30- Rhabdomyosarcoma (met to bone marrow) 
                 0.2 
               
               
                   
                 A431- Epidermoid carcinoma 
                 0.0 
               
               
                   
                 WM266-4- Melanoma 
                 0.0 
               
               
                   
                 DU 145- Prostate carcinoma (brain 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 MDA-MB-468- Breast adenocarcinoma 
                 1.3 
               
               
                   
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-9- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 CAL 27- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3024, Run 164886426    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ARF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 4.4 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.0 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 4.7 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 5.3 
               
               
                   
                 HUVEC none 
                 24.7 
               
               
                   
                 HUVEC starved 
                 11.8 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 31.4 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 14.9 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 8.8 
               
               
                   
                 HUVEC IL-11 
                 11.4 
               
               
                   
                 Lung Microvascular EC none 
                 10.1 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 8.7 
               
               
                   
                 Microvascular Dermal EC none 
                 11.3 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 3.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 5.3 
               
               
                   
                 Small airway epithelium none 
                 3.7 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 66.0 
               
               
                   
                 Coronery artery SMC rest 
                 21.0 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 10.4 
               
               
                   
                 Astrocytes rest 
                 0.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Liver cirrhosis 
                 17.7 
               
               
                   
                 Lupus kidney 
                 5.6 
               
               
                   
                 NCI-H292 none 
                 3.2 
               
               
                   
                 NCI-H292 IL-4 
                 0.0 
               
               
                   
                 NCI-H292 IL-9 
                 10.4 
               
               
                   
                 NCI-H292 IL-13 
                 0.0 
               
               
                   
                 NCI-H292 IFN gamma 
                 0.0 
               
               
                   
                 HPAEC none 
                 6.3 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 3.2 
               
               
                   
                 Lung fibroblast none 
                 0.0 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast IL-4 
                 0.0 
               
               
                   
                 Lung fibroblast IL-9 
                 0.0 
               
               
                   
                 Lung fibroblast IL-13 
                 0.0 
               
               
                   
                 Lung fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 4.1 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 6.1 
               
               
                   
                 Dermal fibroblast IL-4 
                 8.7 
               
               
                   
                 IBD Colitis 2 
                 0.0 
               
               
                   
                 IBD Crohn&#39;s 
                 7.7 
               
               
                   
                 Colon 
                 24.1 
               
               
                   
                 Lung 
                 14.5 
               
               
                   
                 Thymus 
                 100.0 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3024, Run 162427416    
               
            
           
         
       
     
      AI_comprehensive panel_v1.0 Summary: Ag3024 This gene was found at low but significant levels in lung tissue from COPD, emphysema and asthma patients. This expression was consistent with panel 4D which showed expression in small airway epithelium. Therefore, this gene is useful as a marker or a target for lung inflammatory diseases.  
      Panel 1.3D Summary: Ag3024 Expression of this gene, a heparin sulfate proteoglycan homolog, was highly brain preferential and plays a role for this gene product in CNS processes. Heparin sulfate proteoglycans (HSPGs) are a component of amyloid plaques in Alzheimer&#39;s disease. The interaction of apoE with HSPGs has also been implicated in the pathogenesis of Alzheimer&#39;s disease and plays a role in neuronal repair. apoE has an HSPG-binding site highly complementary to heparan sulfates rich in N- and O-sulfo groups. (Libeu C P, E. J Biol Chem 2001 October 19;276(42):39138-44). Enzymes that influence the structure of HSPGs, such as the protein product of this gene, will influence protein agregation and the functional processes underlying Alzheimer&#39;s disease. Agents that target and modulate the activity of this gene or gene product are effective in the treatment of neurodegenerative diseases including Alzheimer&#39;s disease. This gene was also expressed in breast and brain cancer cell lines at low but significant levels. The expression of this gene is of use as a marker for breast and brain cancer. Therapeutic inhibition of the activity of the product of this gene, through the use of antibodies or small molecule drugs, is useful in the therapy of brain and breast cancer.  
      Panel 2D Summary: Ag3024 This gene was expressed at low but significant levels in most of the samples on this panel, with highest expression in a kidney cancer sample (CT=30.6). Significant levels of expression were also seen in samples derived from breast and gastric cancer samples. Expression of this gene is of use as a marker for breast and gastric cancer. Therapeutic inhibition of the activity of the product of this gene or gene product, through the use of antibodies or small molecule drugs, is of use in the therapy of breast and gastric cancer.  
      Panel 3D Summary: Ag3024 This gene was expressed at low but significant levels in cell lines from a renal carcinoma, colon cancer, glioblastoma and three lung cancer lines. Thus, this gene is useful as a marker as well as a target for inhibition of these cancers.  
      Panel 4D Summary: Ag3024 This gene, a heparin Sulfate 6-Sulfotransferase 3 homolog, was expressed at low but significant levels in thymus and small airway epithelium treated with TNFalpha+IL-1beta (CTs=34). The gene product is of use as a marker for thymus or activated small airway epithelium.  
      AS. CG56904-01: Secreted LRR (Leucine-rich Repeat) Protein  
      Expression of gene CG56904-01 was assessed using the primer-probe sets Ag3048, and Ag6717, described in Tables ASA and ASB. Results of the RTQ-PCR runs are shown in Tables ASC, ASD, ASE, ASF, and ASG.  
               TABLE ASA                          Probe Name Ag3048                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-cacaaccagctgacagacagt-3′   21   490   1504                   Probe   TET-5′-ccaccaccttcagcaagctgcatag-3′-   25   521   1505               Reverse   5′-gggagagatccaggtattcaag-3′   22   547   1506                  
 
     
       
         
           
               
             
               
                 TABLE ASB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag6717 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-gctcacaacaagaacaatctc-3 
                 21 
                 406 
                 1507 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-aaggtgccccgaggagc-3′-TAMRA 
                 17 
                 433 
                 1508 
               
               
                   
               
               
                 Reverse 
                 5′-cacggagttgagtctgg-3′ 
                 17 
                 459 
                 1509 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ASC 
               
             
            
               
                   
               
               
                   
               
               
                 AI_comprehensive panel_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 110967 COPD-F 
                 0.0 
               
               
                   
                 110980 COPD-F 
                 0.7 
               
               
                   
                 110968 COPD-M 
                 1.0 
               
               
                   
                 110977 COPD-M 
                 0.8 
               
               
                   
                 110989 Emphysema-F 
                 0.8 
               
               
                   
                 110992 Emphysema-F 
                 6.3 
               
               
                   
                 110993 Emphysema-F 
                 0.3 
               
               
                   
                 110994 Emphysema-F 
                 0.0 
               
               
                   
                 110995 Emphysema-F 
                 12.7 
               
               
                   
                 110996 Emphysema-F 
                 6.6 
               
               
                   
                 110997 Asthma-M 
                 2.6 
               
               
                   
                 111001 Asthma-F 
                 0.4 
               
               
                   
                 111002 Asthma-F 
                 1.9 
               
               
                   
                 111003 Atopic Asthma-F 
                 1.6 
               
               
                   
                 111004 Atopic Asthma-F 
                 5.2 
               
               
                   
                 111005 Atopic Asthma-F 
                 2.8 
               
               
                   
                 111006 Atopic Asthma-F 
                 0.3 
               
               
                   
                 111417 Allergy-M 
                 0.4 
               
               
                   
                 112347 Allergy-M 
                 0.0 
               
               
                   
                 112349 Normal Lung-F 
                 0.0 
               
               
                   
                 112357 Normal Lung-F 
                 8.5 
               
               
                   
                 112354 Normal Lung-M 
                 0.9 
               
               
                   
                 112374 Crohns-F 
                 4.0 
               
               
                   
                 112389 Match Control Crohns-F 
                 17.3 
               
               
                   
                 112375 Crohns-F 
                 4.2 
               
               
                   
                 112732 Match Control Crohns-F 
                 1.1 
               
               
                   
                 112725 Crohns-M 
                 0.0 
               
               
                   
                 112387 Match Control Crohns-M 
                 3.6 
               
               
                   
                 112378 Crohns-M 
                 0.0 
               
               
                   
                 112390 Match Control Crohns-M 
                 0.5 
               
               
                   
                 112726 Crohns-M 
                 0.0 
               
               
                   
                 112731 Match Control Crohns-M 
                 1.4 
               
               
                   
                 112380 Ulcer Col-F 
                 0.9 
               
               
                   
                 112734 Match Control Ulcer Col-F 
                 4.9 
               
               
                   
                 112384 Ulcer Col-F 
                 6.8 
               
               
                   
                 112737 Match Control Ulcer Col-F 
                 0.7 
               
               
                   
                 112386 Ulcer Col-F 
                 7.0 
               
               
                   
                 112738 Match Control Ulcer Col-F 
                 5.1 
               
               
                   
                 112381 Ulcer Col-M 
                 0.0 
               
               
                   
                 112735 Match Control Ulcer Col-M 
                 0.0 
               
               
                   
                 112382 Ulcer Col-M 
                 11.8 
               
               
                   
                 112394 Match Control Ulcer Col-M 
                 1.6 
               
               
                   
                 112383 Ulcer Col-M 
                 30.8 
               
               
                   
                 112736 Match Control Ulcer Col-M 
                 6.3 
               
               
                   
                 112423 Psoriasis-F 
                 0.7 
               
               
                   
                 112427 Match Control Psoriasis-F 
                 1.4 
               
               
                   
                 112418 Psoriasis-M 
                 0.6 
               
               
                   
                 112723 Match Control Psoriasis-M 
                 4.8 
               
               
                   
                 112419 Psoriasis-M 
                 0.9 
               
               
                   
                 112424 Match Control Psoriasis-M 
                 0.9 
               
               
                   
                 112420 Psoriasis-M 
                 6.4 
               
               
                   
                 112425 Match Control Psoriasis-M 
                 0.4 
               
               
                   
                 104689 (MF) OA Bone-Backus 
                 54.7 
               
               
                   
                 104690 (MF) Adj “Normal” Bone-Backus 
                 23.3 
               
               
                   
                 104691 (MF) OA Synovium-Backus 
                 5.3 
               
               
                   
                 104692 (BA) OA Cartilage-Backus 
                 0.0 
               
               
                   
                 104694 (BA) OA Bone-Backus 
                 100.0 
               
               
                   
                 104695 (BA) Adj “Normal” Bone-Backus 
                 80.1 
               
               
                   
                 104696 (BA) OA Synovium-Backus 
                 27.4 
               
               
                   
                 104700 (SS) OA Bone-Backus 
                 21.6 
               
               
                   
                 104701 (SS) Adj “Normal” Bone-Backus 
                 90.8 
               
               
                   
                 104702 (SS) OA Synovium-Backus 
                 76.3 
               
               
                   
                 117093 OA Cartilage Rep7 
                 7.9 
               
               
                   
                 112672 OA Bone5 
                 0.7 
               
               
                   
                 112673 OA Synovium5 
                 0.4 
               
               
                   
                 112674 OA Synovial Fluid cells5 
                 0.0 
               
               
                   
                 117100 OA Cartilage Rep14 
                 0.0 
               
               
                   
                 112756 OA Bone9 
                 8.6 
               
               
                   
                 112757 OA Synovium9 
                 0.7 
               
               
                   
                 112758 OA Synovial Fluid Cells9 
                 3.8 
               
               
                   
                 117125 RA Cartilage Rep2 
                 0.5 
               
               
                   
                 113492 Bone2 RA 
                 3.7 
               
               
                   
                 113493 Synovium2 RA 
                 1.2 
               
               
                   
                 113494 Syn Fluid Cells RA 
                 1.9 
               
               
                   
                 113499 Cartilage4 RA 
                 1.4 
               
               
                   
                 113500 Bone4 RA 
                 3.1 
               
               
                   
                 113501 Synovium4 RA 
                 2.4 
               
               
                   
                 113502 Syn Fluid Cells4 RA 
                 1.2 
               
               
                   
                 113495 Cartilage3 RA 
                 2.0 
               
               
                   
                 113496 Bone3 RA 
                 2.0 
               
               
                   
                 113497 Synovium3 RA 
                 1.7 
               
               
                   
                 113498 Syn Fluid Cells3 RA 
                 2.5 
               
               
                   
                 117106 Normal Cartilage Rep20 
                 0.4 
               
               
                   
                 113663 Bone3 Normal 
                 0.0 
               
               
                   
                 113664 Synovium3 Normal 
                 0.0 
               
               
                   
                 113665 Syn Fluid Cells3 Normal 
                 0.0 
               
               
                   
                 117107 Normal Cartilage Rep22 
                 0.0 
               
               
                   
                 113667 Bone4 Normal 
                 0.4 
               
               
                   
                 113668 Synovium4 Normal 
                 0.5 
               
               
                   
                 113669 Syn Fluid Cells4 Normal 
                 1.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag6717, Run 283839606    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ASD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 2.0 
               
               
                   
                 Pancreas 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.3 
               
               
                   
                 Adrenal gland 
                 0.0 
               
               
                   
                 Thyroid 
                 0.5 
               
               
                   
                 Salivary gland 
                 0.6 
               
               
                   
                 Pituitary gland 
                 0.5 
               
               
                   
                 Brain (fetal) 
                 0.9 
               
               
                   
                 Brain (whole) 
                 2.4 
               
               
                   
                 Brain (amygdala) 
                 2.9 
               
               
                   
                 Brain (cerebellum) 
                 7.0 
               
               
                   
                 Brain (hippocampus) 
                 2.1 
               
               
                   
                 Brain (substantia nigra) 
                 4.5 
               
               
                   
                 Brain (thalamus) 
                 4.6 
               
               
                   
                 Cerebral Cortex 
                 1.0 
               
               
                   
                 Spinal cord 
                 7.6 
               
               
                   
                 glio/astro U87-MG 
                 2.8 
               
               
                   
                 glio/astro U-118-MG 
                 5.9 
               
               
                   
                 astrocytoma SW1783 
                 2.7 
               
               
                   
                 neuro*; met SK-N-AS 
                 1.1 
               
               
                   
                 astrocytoma SF-539 
                 100.0 
               
               
                   
                 astrocytoma SNB-75 
                 41.2 
               
               
                   
                 glioma SNB-19 
                 0.4 
               
               
                   
                 glioma U251 
                 6.7 
               
               
                   
                 glioma SF-295 
                 7.3 
               
               
                   
                 Heart (fetal) 
                 5.1 
               
               
                   
                 Heart 
                 1.3 
               
               
                   
                 Skeletal muscle (fetal) 
                 4.7 
               
               
                   
                 Skeletal muscle 
                 2.6 
               
               
                   
                 Bone marrow 
                 0.9 
               
               
                   
                 Thymus 
                 0.9 
               
               
                   
                 Spleen 
                 0.3 
               
               
                   
                 Lymph node 
                 0.0 
               
               
                   
                 Colorectal 
                 2.9 
               
               
                   
                 Stomach 
                 0.8 
               
               
                   
                 Small intestine 
                 1.0 
               
               
                   
                 Colon ca. SW480 
                 0.8 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 1.9 
               
               
                   
                 Colon ca. HT29 
                 0.3 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.2 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 13.2 
               
               
                   
                 Colon ca. HCC-2998 
                 4.1 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 1.5 
               
               
                   
                 Bladder 
                 3.0 
               
               
                   
                 Trachea 
                 3.7 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                 Kidney (fetal) 
                 0.6 
               
               
                   
                 Renal ca. 786-0 
                 3.8 
               
               
                   
                 Renal ca. A498 
                 17.7 
               
               
                   
                 Renal ca. RXF 393 
                 12.5 
               
               
                   
                 Renal ca. ACHN 
                 0.1 
               
               
                   
                 Renal ca. UO-31 
                 1.1 
               
               
                   
                 Renal ca. TK-10 
                 0.5 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Liver (fetal) 
                 0.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.2 
               
               
                   
                 Lung 
                 1.4 
               
               
                   
                 Lung (fetal) 
                 7.1 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.2 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.9 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.4 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 41.2 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 1.6 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
               
               
                   
                 Mammary gland 
                 15.9 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 3.5 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 2.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.3 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.3 
               
               
                   
                 Ovary 
                 3.8 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.2 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.2 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 4.3 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.8 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 1.5 
               
               
                   
                 Uterus 
                 0.6 
               
               
                   
                 Placenta 
                 0.9 
               
               
                   
                 Prostate 
                 3.0 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 1.7 
               
               
                   
                 Testis 
                 3.9 
               
               
                   
                 Melanoma Hs688(A).T 
                 32.8 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 31.4 
               
               
                   
                 Melanoma UACC-62 
                 1.8 
               
               
                   
                 Melanoma M14 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
               
               
                   
                 Adipose 
                 4.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3048, Run 168017062    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ASE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 4.7 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 12.0 
               
               
                   
                 CC Margin (ODO3866) 
                 1.5 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 10.1 
               
               
                   
                 CC Margin (ODO3868) 
                 0.8 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 8.4 
               
               
                   
                 CC Margin (ODO3920) 
                 2.6 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 13.6 
               
               
                   
                 CC Margin (ODO3921) 
                 2.1 
               
               
                   
                 CC from Partial Hepatectomy (ODO4309) Mets 
                 3.1 
               
               
                   
                 Liver Margin (ODO4309) 
                 0.1 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 3.3 
               
               
                   
                 Lung Margin (OD04451-02) 
                 1.1 
               
               
                   
                 Normal Prostate 6546-1 
                 4.1 
               
               
                   
                 Prostate Cancer (OD04410) 
                 19.8 
               
               
                   
                 Prostate Margin (OD04410) 
                 4.5 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 9.7 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 7.5 
               
               
                   
                 Normal Lung 061010 
                 3.3 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 24.5 
               
               
                   
                 Muscle Margin (ODO4286) 
                 1.7 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 11.6 
               
               
                   
                 Lung Margin (OD03126) 
                 3.1 
               
               
                   
                 Lung Cancer (OD04404) 
                 22.2 
               
               
                   
                 Lung Margin (OD04404) 
                 7.2 
               
               
                   
                 Lung Cancer (OD04565) 
                 36.1 
               
               
                   
                 Lung Margin (OD04565) 
                 2.0 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 12.6 
               
               
                   
                 Lung Margin (OD04237-02) 
                 6.7 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 0.0 
               
               
                   
                 Liver Margin (ODO4310) 
                 0.4 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.0 
               
               
                   
                 Lung Margin (OD04321) 
                 1.7 
               
               
                   
                 Normal Kidney 
                 0.8 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 0.3 
               
               
                   
                 Kidney Margin (OD04338) 
                 1.5 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 0.2 
               
               
                   
                 Kidney Margin (OD04339) 
                 0.9 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 0.4 
               
               
                   
                 Kidney Margin (OD04340) 
                 1.0 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 10.3 
               
               
                   
                 Kidney Margin (OD04348) 
                 0.4 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 34.4 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 0.2 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 0.2 
               
               
                   
                 Kidney Cancer 8120607 
                 9.0 
               
               
                   
                 Kidney Margin 8120608 
                 0.5 
               
               
                   
                 Kidney Cancer 8120613 
                 0.1 
               
               
                   
                 Kidney Margin 8120614 
                 0.4 
               
               
                   
                 Kidney Cancer 9010320 
                 13.1 
               
               
                   
                 Kidney Margin 9010321 
                 0.9 
               
               
                   
                 Normal Uterus 
                 0.5 
               
               
                   
                 Uterus Cancer 064011 
                 1.0 
               
               
                   
                 Normal Thyroid 
                 3.3 
               
               
                   
                 Thyroid Cancer 064010 
                 0.7 
               
               
                   
                 Thyroid Cancer A302152 
                 4.5 
               
               
                   
                 Thyroid Margin A302153 
                 0.8 
               
               
                   
                 Normal Breast 
                 20.0 
               
               
                   
                 Breast Cancer (OD04566) 
                 6.5 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 10.4 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 11.4 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 1.0 
               
               
                   
                 Breast Cancer 064006 
                 23.2 
               
               
                   
                 Breast Cancer 1024 
                 25.7 
               
               
                   
                 Breast Cancer 9100266 
                 16.4 
               
               
                   
                 Breast Margin 9100265 
                 24.0 
               
               
                   
                 Breast Cancer A209073 
                 32.3 
               
               
                   
                 Breast Margin A209073 
                 33.2 
               
               
                   
                 Normal Liver 
                 0.0 
               
               
                   
                 Liver Cancer 064003 
                 0.0 
               
               
                   
                 Liver Cancer 1025 
                 0.0 
               
               
                   
                 Liver Cancer 1026 
                 4.2 
               
               
                   
                 Liver Cancer 6004-T 
                 0.0 
               
               
                   
                 Liver Tissue 6004-N 
                 2.9 
               
               
                   
                 Liver Cancer 6005-T 
                 2.2 
               
               
                   
                 Liver Tissue 6005-N 
                 0.0 
               
               
                   
                 Normal Bladder 
                 23.8 
               
               
                   
                 Bladder Cancer 1023 
                 11.8 
               
               
                   
                 Bladder Cancer A302173 
                 7.2 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 12.7 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 4.9 
               
               
                   
                 Normal Ovary 
                 3.5 
               
               
                   
                 Ovarian Cancer 064008 
                 100.0 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 2.5 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 8.1 
               
               
                   
                 Normal Stomach 
                 1.5 
               
               
                   
                 Gastric Cancer 9060358 
                 0.5 
               
               
                   
                 Stomach Margin 9060359 
                 0.8 
               
               
                   
                 Gastric Cancer 9060395 
                 7.5 
               
               
                   
                 Stomach Margin 9060394 
                 1.9 
               
               
                   
                 Gastric Cancer 9060397 
                 27.0 
               
               
                   
                 Stomach Margin 9060396 
                 1.5 
               
               
                   
                 Gastric Cancer 064005 
                 3.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3048, Run 170858352    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ASF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Daoy- Medulloblastoma 
                 6.5 
               
               
                   
                 TE671- Medulloblastoma 
                 0.0 
               
               
                   
                 D283 Med- Medulloblastoma 
                 0.0 
               
               
                   
                 PFSK-1- Primitive Neuroectodermal 
                 18.0 
               
               
                   
                 XF-498- CNS 
                 1.4 
               
               
                   
                 SNB-78- Glioma 
                 100.0 
               
               
                   
                 SF-268- Glioblastoma 
                 0.0 
               
               
                   
                 T98G- Glioblastoma 
                 24.1 
               
               
                   
                 SK-N-SH- Neuroblastoma (metastasis) 
                 32.3 
               
               
                   
                 SF-295- Glioblastoma 
                 2.0 
               
               
                   
                 Cerebellum 
                 3.0 
               
               
                   
                 Cerebellum 
                 4.2 
               
               
                   
                 NCI-H292- Mucoepidermoid lung carcinoma 
                 38.4 
               
               
                   
                 DMS-114- Small cell lung cancer 
                 1.7 
               
               
                   
                 DMS-79- Small cell lung cancer 
                 3.0 
               
               
                   
                 NCI-H146- Small cell lung cancer 
                 3.3 
               
               
                   
                 NCI-H526- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-N417- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H82- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H157- Squamous cell lung cancer 
                 1.4 
               
               
                   
                 (metastasis) 
               
               
                   
                 NCI-H1155- Large cell lung cancer 
                 1.8 
               
               
                   
                 NCI-H1299- Large cell lung cancer 
                 2.8 
               
               
                   
                 NCI-H727- Lung carcinoid 
                 0.0 
               
               
                   
                 NCI-UMC-11- Lung carcinoid 
                 0.0 
               
               
                   
                 LX-1- Small cell lung cancer 
                 0.0 
               
               
                   
                 Colo-205- Colon cancer 
                 7.3 
               
               
                   
                 KM12- Colon cancer 
                 1.6 
               
               
                   
                 KM20L2- Colon cancer 
                 0.0 
               
               
                   
                 NCI-H716- Colon cancer 
                 0.0 
               
               
                   
                 SW-48- Colon adenocarcinoma 
                 0.6 
               
               
                   
                 SW1116- Colon adenocarcinoma 
                 0.8 
               
               
                   
                 LS 174T- Colon adenocarcinoma 
                 2.5 
               
               
                   
                 SW-948- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-480- Colon adenocarcinoma 
                 2.7 
               
               
                   
                 NCI-SNU-5- Gastric carcinoma 
                 1.6 
               
               
                   
                 KATO III- Gastric carcinoma 
                 1.8 
               
               
                   
                 NCI-SNU-16- Gastric carcinoma 
                 1.4 
               
               
                   
                 NCI-SNU-1- Gastric carcinoma 
                 0.0 
               
               
                   
                 RF-1- Gastric adenocarcinoma 
                 0.0 
               
               
                   
                 RF-48- Gastric adenocarcinoma 
                 0.9 
               
               
                   
                 MKN-45- Gastric carcinoma 
                 5.6 
               
               
                   
                 NCI-N87- Gastric carcinoma 
                 2.3 
               
               
                   
                 OVCAR-5- Ovarian carcinoma 
                 4.8 
               
               
                   
                 RL95-2- Uterine carcinoma 
                 0.0 
               
               
                   
                 HelaS3- Cervical adenocarcinoma 
                 0.0 
               
               
                   
                 Ca Ski- Cervical epidermoid carcinoma 
                 0.0 
               
               
                   
                 (metastasis) 
               
               
                   
                 ES-2- Ovarian clear cell carcinoma 
                 0.0 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 0.0 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 0.0 
               
               
                   
                 MEG-01- Chronic myelogenous leukemia 
                 2.6 
               
               
                   
                 (megokaryoblast) 
               
               
                   
                 Raji- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 Daudi- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 U266- B-cell plasmacytoma 
                 0.0 
               
               
                   
                 CA46- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 0.0 
               
               
                   
                 JM1- pre-B-cell lymphoma 
                 0.0 
               
               
                   
                 Jurkat- T cell leukemia 
                 0.0 
               
               
                   
                 TF-1- Erythroleukemia 
                 2.3 
               
               
                   
                 HUT 78- T-cell lymphoma 
                 0.0 
               
               
                   
                 U937- Histiocytic lymphoma 
                 0.7 
               
               
                   
                 KU-812- Myelogenous leukemia 
                 0.0 
               
               
                   
                 769-P- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 Caki-2- Clear cell renal carcinoma 
                 2.5 
               
               
                   
                 SW 839- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 Rhabdoid kidney tumor 
                 2.3 
               
               
                   
                 Hs766T- Pancreatic carcinoma (LN 
                 1.5 
               
               
                   
                 metastasis) 
               
               
                   
                 CAPAN-1- Pancreatic adenocarcinoma (liver 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 SU86.86- Pancreatic carcinoma (liver 
                 0.8 
               
               
                   
                 metastasis) 
               
               
                   
                 BxPC-3- Pancreatic adenocarcinoma 
                 0.7 
               
               
                   
                 HPAC- Pancreatic adenocarcinoma 
                 0.0 
               
               
                   
                 MIA PaCa-2- Pancreatic carcinoma 
                 0.7 
               
               
                   
                 CFPAC-1- Pancreatic ductal adenocarcinoma 
                 1.7 
               
               
                   
                 PANC-1- Pancreatic epithelioid ductal 
                 6.7 
               
               
                   
                 carcinoma 
               
               
                   
                 T24- Bladder carcinma (transitional cell) 
                 6.1 
               
               
                   
                 5637- Bladder carcinoma 
                 2.1 
               
               
                   
                 HT-1197- Bladder carcinoma 
                 1.7 
               
               
                   
                 UM-UC-3- Bladder carcinma (transitional cell) 
                 0.7 
               
               
                   
                 A204- Rhabdomyosarcoma 
                 5.4 
               
               
                   
                 HT-1080- Fibrosarcoma 
                 11.7 
               
               
                   
                 MG-63- Osteosarcoma 
                 0.0 
               
               
                   
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 7.5 
               
               
                   
                 SJRH30- Rhabdomyosarcoma (met to bone 
                 0.0 
               
               
                   
                 marrow) 
               
               
                   
                 A431- Epidermoid carcinoma 
                 5.1 
               
               
                   
                 WM266-4- Melanoma 
                 16.6 
               
               
                   
                 DU 145- Prostate carcinoma (brain 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 MDA-MB-468- Breast adenocarcinoma 
                 2.5 
               
               
                   
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-9- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.6 
               
               
                   
                 CAL 27- Squamous cell carcinoma of tongue 
                 0.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3048, Run 172133336    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ASG 
               
               
                   
               
               
                   
               
               
                 Panel 4D 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 1.9 
               
               
                   
                 Macrophages LPS 
                 1.3 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 2.9 
               
               
                   
                 Colon 
                 2.0 
               
               
                   
                 Lung 
                 36.1 
               
               
                   
                 Thymus 
                 0.6 
               
               
                   
                 Kidney 
                 1.7 
               
               
                   
                   
               
            
           
         
       
     
      AI_comprehensive panel_v1.0 Summary: Ag6717 Prominent expression was seen in bone and synovium samples from osteoarthritis patients, with highest expression in an OA bone sample (CT=31). Thus, targeting this gene or its protein product is useful in the treatment of osteoarthritis.  
      Panel 1.3D Summary: Ag3048 The expression of this gene was highest in a sample derived from a brain cancer cell line (SF-539) (CT=29.4). There was substantial expression associated with samples derived from another brain cancer cell line, two melanoma cell lines and a lung cancer cell line. The expression of this gene is useful as a marker to distinguish SF-539 cells from other samples in the panel. Therapeutic modulation of this gene, through the use of small molecule drugs, protein therapeuitcs or antibodies is of benefit in treatment of brain or lung cancer or melanoma.  
      This gene, a leucine-rich repeat homolog, was expressed at low levels in the CNS. The leucine-rich repeat region proteins have been implicated in axonal guidance. This gene has therapeutic utility in the treatment of any CNS disorder involving neuronal loss, specfically by guiding/enhancing compensatory synaptogenesis and fiber outgrowth, including such clinical conditions as Alzheimer&#39;s, Parkinson&#39;s, or Huntington&#39;s diseases, stroke, head and spinal cord trauma, vascular dementia or spinocerebellar ataxia.  
      Panel 2D Summary: Ag3048 The expression of this gene was highest in a sample derived from an ovarian cancer (CT=29). There was substantial expression associated with lung cancer, prostate cancer and colon cancer samples. Of note is the differential expression in the lung, colon and prostate cancer samples compared to their respective normal adjacent tissue. The expression of this gene is useful as a marker to distinguish this ovarian cancer sample from other samples in the panel. The expression of this gene or its protein product is useful as a marker to distinguish colon, prostate or lung cancer samples from their normal adjacent tissue. Therapeutic modulation of this gene or its protein product, through the use of small molecule drugs, protein therapeutics or antibodies is benefical in the treatment of ovarian, lung, prostate or colon cancer.  
      Panel 3D Sumunary: Ag3048 The expression of this gene was highest in a sample derived from a brain cancer cell line (SNB-78) (CT=30.2). There was substantial expression associated with other brain cancer cell line samples and a lung cancer cell line sample. The expression of this gene is useful as a marker to distinguish SNB-78 cells from other samples in the panel. Therapeutic modulation of this gene or its protein product, through the use of small molecule drugs, protein therapeutics or antibodies is useful in the treatment of brain or lung cancer.  
      Panel 4D Summary: Ag3048 This gene, a secreted leucine-rich repeat (LRR) protein, was expressed selectively at moderate levels (CT range 29-31) in several resting and cytokine-activated epithelial and connective tissue cells of lung and skin. This gene product is useful as a therapeutic protein as well as a target for therapeutic antibodies and small molecules, for the reduction or elimination of the symptoms in patients with chronic obstructive pulmonary disease, asthma, emphysema, or psoriasis.  
      AT. CG56904-04: LRR Protein  
      Expression of gene CG56904-04 was assessed using the primer-probe set Ag3048, described in Table ATA. Results of the RTQ-PCR runs are shown in Tables ATB, ATC, ATD and ATE.  
               TABLE ATA                          Probe Name Ag3048                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-cacaaccagctgacagacagt-3′   21   724   1510                   Probe   TET-5′-ccaccaccttcagcaagctgcatag-3′-   25   755   1511           TAMRA               Reverse   5′-gggagagatccaggtattcaag-3′   22   781   1512                  
 
     
       
         
           
               
             
               
                 TABLE ATB 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 2.0 
               
               
                   
                 Pancreas 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.3 
               
               
                   
                 Adrenal gland 
                 0.0 
               
               
                   
                 Thyroid 
                 0.5 
               
               
                   
                 Salivary gland 
                 0.6 
               
               
                   
                 Pituitary gland 
                 0.5 
               
               
                   
                 Brain (fetal) 
                 0.9 
               
               
                   
                 Brain (whole) 
                 2.4 
               
               
                   
                 Brain (amygdala) 
                 2.9 
               
               
                   
                 Brain (cerebellum) 
                 7.0 
               
               
                   
                 Brain (hippocampus) 
                 2.1 
               
               
                   
                 Brain (substantia nigra) 
                 4.5 
               
               
                   
                 Brain (thalamus) 
                 4.6 
               
               
                   
                 Cerebral Cortex 
                 1.0 
               
               
                   
                 Spinal cord 
                 7.6 
               
               
                   
                 glio/astro U87-MG 
                 2.8 
               
               
                   
                 glio/astro U-118-MG 
                 5.9 
               
               
                   
                 astrocytoma SW1783 
                 2.7 
               
               
                   
                 neuro*; met SK-N-AS 
                 1.1 
               
               
                   
                 astrocytoma SF-539 
                 100.0 
               
               
                   
                 astrocytoma SNB-75 
                 41.2 
               
               
                   
                 glioma SNB-19 
                 0.4 
               
               
                   
                 glioma U251 
                 6.7 
               
               
                   
                 glioma SF-295 
                 7.3 
               
               
                   
                 Heart (fetal) 
                 5.1 
               
               
                   
                 Heart 
                 1.3 
               
               
                   
                 Skeletal muscle (fetal) 
                 4.7 
               
               
                   
                 Skeletal muscle 
                 2.6 
               
               
                   
                 Bone marrow 
                 0.9 
               
               
                   
                 Thymus 
                 0.9 
               
               
                   
                 Spleen 
                 0.3 
               
               
                   
                 Lymph node 
                 0.0 
               
               
                   
                 Colorectal 
                 2.9 
               
               
                   
                 Stomach 
                 0.8 
               
               
                   
                 Small intestine 
                 1.0 
               
               
                   
                 Colon ca. SW480 
                 0.8 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 1.9 
               
               
                   
                 Colon ca. HT29 
                 0.3 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.2 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 13.2 
               
               
                   
                 Colon ca. HCC-2998 
                 4.1 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 1.5 
               
               
                   
                 Bladder 
                 3.0 
               
               
                   
                 Trachea 
                 3.7 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                 Kidney (fetal) 
                 0.6 
               
               
                   
                 Renal ca. 786-0 
                 3.8 
               
               
                   
                 Renal ca. A498 
                 17.7 
               
               
                   
                 Renal ca. RXF 393 
                 12.5 
               
               
                   
                 Renal ca. ACHN 
                 0.1 
               
               
                   
                 Renal ca. UO-31 
                 1.1 
               
               
                   
                 Renal ca. TK-10 
                 0.5 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Liver (fetal) 
                 0.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.2 
               
               
                   
                 Lung 
                 1.4 
               
               
                   
                 Lung (fetal) 
                 7.1 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.2 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.9 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.4 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 41.2 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 1.6 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
               
               
                   
                 Mammary gland 
                 15.9 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 3.5 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 2.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.3 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.3 
               
               
                   
                 Ovary 
                 3.8 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.2 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.2 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 4.3 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.8 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 1.5 
               
               
                   
                 Uterus 
                 0.6 
               
               
                   
                 Placenta 
                 0.9 
               
               
                   
                 Prostate 
                 3.0 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 1.7 
               
               
                   
                 Testis 
                 3.9 
               
               
                   
                 Melanoma Hs688(A).T 
                 32.8 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 31.4 
               
               
                   
                 Melanoma UACC-62 
                 1.8 
               
               
                   
                 Melanoma M14 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
               
               
                   
                 Adipose 
                 4.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3048, Run 168017062    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ATC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 4.7 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 12.0 
               
               
                   
                 CC Margin (ODO3866) 
                 1.5 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 10.1 
               
               
                   
                 CC Margin (ODO3868) 
                 0.8 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 8.4 
               
               
                   
                 CC Margin (ODO3920) 
                 2.6 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 13.6 
               
               
                   
                 CC Margin (ODO3921) 
                 2.1 
               
               
                   
                 CC from Partial Hepatectomy (ODO4309) Mets 
                 3.1 
               
               
                   
                 Liver Margin (ODO4309) 
                 0.1 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 3.3 
               
               
                   
                 Lung Margin (OD04451-02) 
                 1.1 
               
               
                   
                 Normal Prostate 6546-1 
                 4.1 
               
               
                   
                 Prostate Cancer (OD04410) 
                 19.8 
               
               
                   
                 Prostate Margin (OD04410) 
                 4.5 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 9.7 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 7.5 
               
               
                   
                 Normal Lung 061010 
                 3.3 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 24.5 
               
               
                   
                 Muscle Margin (ODO4286) 
                 1.7 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 11.6 
               
               
                   
                 Lung Margin (OD03126) 
                 3.1 
               
               
                   
                 Lung Cancer (OD04404) 
                 22.2 
               
               
                   
                 Lung Margin (OD04404) 
                 7.2 
               
               
                   
                 Lung Cancer (OD04565) 
                 36.1 
               
               
                   
                 Lung Margin (OD04565) 
                 2.0 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 12.6 
               
               
                   
                 Lung Margin (OD04237-02) 
                 6.7 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 0.0 
               
               
                   
                 Liver Margin (ODO4310) 
                 0.4 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.0 
               
               
                   
                 Lung Margin (OD04321) 
                 1.7 
               
               
                   
                 Normal Kidney 
                 0.8 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 0.3 
               
               
                   
                 Kidney Margin (OD04338) 
                 1.5 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 0.2 
               
               
                   
                 Kidney Margin (OD04339) 
                 0.9 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 0.4 
               
               
                   
                 Kidney Margin (OD04340) 
                 1.0 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 10.3 
               
               
                   
                 Kidney Margin (OD04348) 
                 0.4 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 34.4 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 0.2 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 0.2 
               
               
                   
                 Kidney Cancer 8120607 
                 9.0 
               
               
                   
                 Kidney Margin 8120608 
                 0.5 
               
               
                   
                 Kidney Cancer 8120613 
                 0.1 
               
               
                   
                 Kidney Margin 8120614 
                 0.4 
               
               
                   
                 Kidney Cancer 9010320 
                 13.1 
               
               
                   
                 Kidney Margin 9010321 
                 0.9 
               
               
                   
                 Normal Uterus 
                 0.5 
               
               
                   
                 Uterus Cancer 064011 
                 1.0 
               
               
                   
                 Normal Thyroid 
                 3.3 
               
               
                   
                 Thyroid Cancer 064010 
                 0.7 
               
               
                   
                 Thyroid Cancer A302152 
                 4.5 
               
               
                   
                 Thyroid Margin A302153 
                 0.8 
               
               
                   
                 Normal Breast 
                 20.0 
               
               
                   
                 Breast Cancer (OD04566) 
                 6.5 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 10.4 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 11.4 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 1.0 
               
               
                   
                 Breast Cancer 064006 
                 23.2 
               
               
                   
                 Breast Cancer 1024 
                 25.7 
               
               
                   
                 Breast Cancer 9100266 
                 16.4 
               
               
                   
                 Breast Margin 9100265 
                 24.0 
               
               
                   
                 Breast Cancer A209073 
                 32.3 
               
               
                   
                 Breast Margin A209073 
                 33.2 
               
               
                   
                 Normal Liver 
                 0.0 
               
               
                   
                 Liver Cancer 064003 
                 0.0 
               
               
                   
                 Liver Cancer 1025 
                 0.0 
               
               
                   
                 Liver Cancer 1026 
                 4.2 
               
               
                   
                 Liver Cancer 6004-T 
                 0.0 
               
               
                   
                 Liver Tissue 6004-N 
                 2.9 
               
               
                   
                 Liver Cancer 6005-T 
                 2.2 
               
               
                   
                 Liver Tissue 6005-N 
                 0.0 
               
               
                   
                 Normal Bladder 
                 23.8 
               
               
                   
                 Bladder Cancer 1023 
                 11.8 
               
               
                   
                 Bladder Cancer A302173 
                 7.2 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 12.7 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 4.9 
               
               
                   
                 Normal Ovary 
                 3.5 
               
               
                   
                 Ovarian Cancer 064008 
                 100.0 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 2.5 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 8.1 
               
               
                   
                 Normal Stomach 
                 1.5 
               
               
                   
                 Gastric Cancer 9060358 
                 0.5 
               
               
                   
                 Stomach Margin 9060359 
                 0.8 
               
               
                   
                 Gastric Cancer 9060395 
                 7.5 
               
               
                   
                 Stomach Margin 9060394 
                 1.9 
               
               
                   
                 Gastric Cancer 9060397 
                 27.0 
               
               
                   
                 Stomach Margin 9060396 
                 1.5 
               
               
                   
                 Gastric Cancer 064005 
                 3.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3048, Run 170858352    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ATD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Daoy- Medulloblastoma 
                 6.5 
               
               
                   
                 TE671- Medulloblastoma 
                 0.0 
               
               
                   
                 D283 Med- Medulloblastoma 
                 0.0 
               
               
                   
                 PFSK-1- Primitive Neuroectodermal 
                 18.0 
               
               
                   
                 XF-498- CNS 
                 1.4 
               
               
                   
                 SNB-78- Glioma 
                 100.0 
               
               
                   
                 SF-268- Glioblastoma 
                 0.0 
               
               
                   
                 T98G- Glioblastoma 
                 24.1 
               
               
                   
                 SK-N-SH- Neuroblastoma (metastasis) 
                 32.3 
               
               
                   
                 SF-295- Glioblastoma 
                 2.0 
               
               
                   
                 Cerebellum 
                 3.0 
               
               
                   
                 Cerebellum 
                 4.2 
               
               
                   
                 NCI-H292- Mucoepidermoid lung 
                 38.4 
               
               
                   
                 carcinoma 
               
               
                   
                 DMS-114- Small cell lung cancer 
                 1.7 
               
               
                   
                 DMS-79- Small cell lung cancer 
                 3.0 
               
               
                   
                 NCI-H146- Small cell lung cancer 
                 3.3 
               
               
                   
                 NCI-H526- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-N417- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H82- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H157- Squamous cell lung cancer 
                 1.4 
               
               
                   
                 (metastasis) 
               
               
                   
                 NCI-H1155- Large cell lung cancer 
                 1.8 
               
               
                   
                 NCI-H1299- Large cell lung cancer 
                 2.8 
               
               
                   
                 NCI-H727- Lung carcinoid 
                 0.0 
               
               
                   
                 NCI-UMC-11- Lung carcinoid 
                 0.0 
               
               
                   
                 LX-1- Small cell lung cancer 
                 0.0 
               
               
                   
                 Colo-205- Colon cancer 
                 7.3 
               
               
                   
                 KM12- Colon cancer 
                 1.6 
               
               
                   
                 KM20L2- Colon cancer 
                 0.0 
               
               
                   
                 NCI-H716- Colon cancer 
                 0.0 
               
               
                   
                 SW-48- Colon adenocarcinoma 
                 0.6 
               
               
                   
                 SW1116- Colon adenocarcinoma 
                 0.8 
               
               
                   
                 LS 174T- Colon adenocarcinoma 
                 2.5 
               
               
                   
                 SW-948- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-480- Colon adenocarcinoma 
                 2.7 
               
               
                   
                 NCI-SNU-5- Gastric carcinoma 
                 1.6 
               
               
                   
                 KATO III- Gastric carcinoma 
                 1.8 
               
               
                   
                 NCI-SNU-16- Gastric carcinoma 
                 1.4 
               
               
                   
                 NCI-SNU-1- Gastric carcinoma 
                 0.0 
               
               
                   
                 RF-1- Gastric adenocarcinoma 
                 0.0 
               
               
                   
                 RF-48- Gastric adenocarcinoma 
                 0.9 
               
               
                   
                 MKN-45- Gastric carcinoma 
                 5.6 
               
               
                   
                 NCI-N87- Gastric carcinoma 
                 2.3 
               
               
                   
                 OVCAR-5- Ovarian carcinoma 
                 4.8 
               
               
                   
                 RL95-2- Uterine carcinoma 
                 0.0 
               
               
                   
                 HelaS3- Cervical adenocarcinoma 
                 0.0 
               
               
                   
                 Ca Ski- Cervical epidermoid carcinoma 
                 0.0 
               
               
                   
                 (metastasis) 
               
               
                   
                 ES-2- Ovarian clear cell carcinoma 
                 0.0 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 0.0 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 0.0 
               
               
                   
                 MEG-01- Chronic myelogenous leukemia 
                 2.6 
               
               
                   
                 (megokaryoblast) 
               
               
                   
                 Raji- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 Daudi- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 U266- B-cell plasmacytoma 
                 0.0 
               
               
                   
                 CA46- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 0.0 
               
               
                   
                 JM1- pre-B-cell lymphoma 
                 0.0 
               
               
                   
                 Jurkat- T cell leukemia 
                 0.0 
               
               
                   
                 TF-1- Erythroleukemia 
                 2.3 
               
               
                   
                 HUT 78- T-cell lymphoma 
                 0.0 
               
               
                   
                 U937- Histiocytic lymphoma 
                 0.7 
               
               
                   
                 KU-812- Myelogenous leukemia 
                 0.0 
               
               
                   
                 769-P- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 Caki-2- Clear cell renal carcinoma 
                 2.5 
               
               
                   
                 SW 839- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 Rhabdoid kidney tumor 
                 2.3 
               
               
                   
                 Hs766T- Pancreatic carcinoma (LN 
                 1.5 
               
               
                   
                 metastasis) 
               
               
                   
                 CAPAN-1- Pancreatic adenocarcinoma (liver 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 SU86.86- Pancreatic carcinoma (liver 
                 0.8 
               
               
                   
                 metastasis) 
               
               
                   
                 BxPC-3- Pancreatic adenocarcinoma 
                 0.7 
               
               
                   
                 HPAC- Pancreatic adenocarcinoma 
                 0.0 
               
               
                   
                 MIA PaCa-2- Pancreatic carcinoma 
                 0.7 
               
               
                   
                 CFPAC-1- Pancreatic ductal adenocarcinoma 
                 1.7 
               
               
                   
                 PANC-1- Pancreatic epithelioid ductal 
                 6.7 
               
               
                   
                 carcinoma 
               
               
                   
                 T24- Bladder carcinma (transitional cell) 
                 6.1 
               
               
                   
                 5637- Bladder carcinoma 
                 2.1 
               
               
                   
                 HT-1197- Bladder carcinoma 
                 1.7 
               
               
                   
                 UM-UC-3- Bladder carcinma (transitional cell) 
                 0.7 
               
               
                   
                 A204- Rhabdomyosarcoma 
                 5.4 
               
               
                   
                 HT-1080- Fibrosarcoma 
                 11.7 
               
               
                   
                 MG-63- Osteosarcoma 
                 0.0 
               
               
                   
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 7.5 
               
               
                   
                 SJRH30- Rhabdomyosarcoma (met to bone 
                 0.0 
               
               
                   
                 marrow) 
               
               
                   
                 A431- Epidermoid carcinoma 
                 5.1 
               
               
                   
                 WM266-4- Melanoma 
                 16.6 
               
               
                   
                 DU 145- Prostate carcinoma (brain 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 MDA-MB-468- Breast adenocarcinoma 
                 2.5 
               
               
                   
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-9- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.6 
               
               
                   
                 CAL 27- Squamous cell carcinoma of tongue 
                 0.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3048, Run 172133336    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE ATE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.4 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.6 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.9 
               
               
                   
                 Primary Tr1 rest 
                 0.6 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 8.6 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.6 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.6 
               
               
                   
                 CD4 lymphocyte none 
                 0.5 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 1.3 
               
               
                   
                 LAK cells rest 
                 0.0 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.8 
               
               
                   
                 PBMC rest 
                 0.8 
               
               
                   
                 PBMC PWM 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 2.2 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.8 
               
               
                   
                 B lymphocytes PWM 
                 1.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 1.8 
               
               
                   
                 Dendritic cells LPS 
                 1.7 
               
               
                   
                 Dendritic cells anti-CD40 
                 6.8 
               
               
                   
                 Monocytes rest 
                 1.2 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 1.9 
               
               
                   
                 Macrophages LPS 
                 1.3 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 2.9 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 1.9 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 1.2 
               
               
                   
                 HUVEC IL-11 
                 0.3 
               
               
                   
                 Lung Microvascular EC none 
                 3.9 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 1.2 
               
               
                   
                 Microvascular Dermal EC none 
                 0.6 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 1.4 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 28.7 
               
               
                   
                 Small airway epithelium none 
                 39.2 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 84.7 
               
               
                   
                 Coronery artery SMC rest 
                 17.9 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 5.5 
               
               
                   
                 Astrocytes rest 
                 6.1 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 5.5 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.7 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 3.8 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 79.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 97.3 
               
               
                   
                 Liver cirrhosis 
                 4.3 
               
               
                   
                 Lupus kidney 
                 3.4 
               
               
                   
                 NCI-H292 none 
                 87.1 
               
               
                   
                 NCI-H292 IL-4 
                 77.4 
               
               
                   
                 NCI-H292 IL-9 
                 82.9 
               
               
                   
                 NCI-H292 IL-13 
                 54.0 
               
               
                   
                 NCI-H292 IFN gamma 
                 49.3 
               
               
                   
                 HPAEC none 
                 0.7 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 35.1 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 7.0 
               
               
                   
                 Lung fibroblast IL-4 
                 46.0 
               
               
                   
                 Lung fibroblast IL-9 
                 38.7 
               
               
                   
                 Lung fibroblast IL-13 
                 26.8 
               
               
                   
                 Lung fibroblast IFN gamma 
                 68.8 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 100.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 59.9 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 39.8 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 17.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 30.6 
               
               
                   
                 IBD Colitis 2 
                 0.0 
               
               
                   
                 IBD Crohn&#39;s 
                 0.7 
               
               
                   
                 Colon 
                 2.0 
               
               
                   
                 Lung 
                 36.1 
               
               
                   
                 Thymus 
                 0.6 
               
               
                   
                 Kidney 
                 1.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3048, Run 164315038    
               
            
           
         
       
     
      Panel 1.3D Summary: Ag3048 The expression of this gene was highest in a sample derived from a brain cancer cell line (SF-539) (CT=29.4). There was substantial expression associated with samples derived from another brain cancer cell line, two melanoma cell lines and a lung cancer cell line. The expression of this gene is useful as a marker to distinguish SF-539 cells from other samples in the panel. Therapeutic modulation of this gene, through the use of small molecule drugs, protein therapeuitcs or antibodies is of benefit in treatment of brain or lung cancer or melanoma.  
      This gene, a leucine-rich repeat homolog, was expressed at low levels in the CNS. The leucine-rich repeat region proteins have been implicated in axonal guidance. This gene has therapeutic utility in the treatment of any CNS disorder involving neuronal loss, specfically by guiding/enhancing compensatory synaptogenesis and fiber outgrowth, including such clinical conditions as Alzheimer&#39;s, Parkinson&#39;s, or Huntington&#39;s diseases, stroke, head and spinal cord trauma, vascular dementia or spinocerebellar ataxia.  
      Panel 2D Summary: Ag3048 The expression of this gene was highest in a sample derived from an ovarian cancer (CT=29). There was substantial expression associated with lung cancer, prostate cancer and colon cancer samples. Of note is the differential expression in the lung, colon and prostate cancer samples compared to their respective normal adjacent tissue. The expression of this gene is useful as a marker to distinguish this ovarian cancer sample from other samples in the panel. The expression of this gene or its protein product is useful as a marker to distinguish colon, prostate or lung cancer samples from their normal adjacent tissue. Therapeutic modulation of this gene or its protein product, through the use of small molecule drugs, protein therapeutics or antibodies is benefical in the treatment of ovarian, lung, prostate or colon cancer.  
      Panel 3D Summary: Ag3048 The expression of this gene was highest in a sample derived from a brain cancer cell line (SNB-78) (CT=30.2). There was substantial expression associated with other brain cancer cell line samples and a lung cancer cell line sample. The expression of this gene is useful as a marker to distinguish SNB-78 cells from other samples in the panel. Therapeutic modulation of this gene or its protein product, through the use of small molecule drugs, protein therapeutics or antibodies is useftil in the treatment of brain or lung cancer.  
      Panel 4D Summary: Ag3048 This gene, a secreted leucine-rich repeat (LRR) protein, was expressed selectively at moderate levels (CT range 29-31) in several resting and cytokine-activated epithelial and connective tissue cells of lung and skin. This gene product is useful as a therapeutic protein as well as a target for therapeutic antibodies and small molecules, for the reduction or elimination of the symptoms in patients with chronic obstructive pulmonary disease, asthma, emphysema, or psoriasis.  
      AU. CG56914-01: Thrombospondin  
      Expression of gene CG56914-01 was assessed using the primer-probe sets Ag3108 and Ag3899, described in Tables AUA and AUB. Results of the RTQ-PCR runs are shown in Tables AUC, AUD, AUE, AUF, AUG.  
               TABLE AUA                          Probe Name Ag3108                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-attccattgcccaaattaaca-3′   21   703   1513                   Probe   TET-5′-ccttcaataacaatattattccagccca-3′-   28   728   1514           TAMRA               Reverse   5′-actgtgtccattcacactgtca-3′   22   759   1515                  
 
     
       
         
           
               
             
               
                 TABLE AUB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag3899 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-ccattgcccaaattaacatg-3′ 
                 20 
                 706 
                 1516 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ccttcaataacaatattattccagccca-3′- 
                 28 
                 728 
                 1517 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-actgtgtccattcacactgtca-3′ 
                 22 
                 759 
                 1518 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AUC 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v_1.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 1.0 
               
               
                   
                 Melanoma* Hs688(A).T 
                 33.9 
               
               
                   
                 Melanoma* Hs688(B).T 
                 8.4 
               
               
                   
                 Melanoma* M14 
                 12.9 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.1 
               
               
                   
                 Melanoma* SK-MEL-5 
                 58.6 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.0 
               
               
                   
                 Testis Pool 
                 0.6 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.2 
               
               
                   
                 Prostate Pool 
                 0.4 
               
               
                   
                 Placenta 
                 0.1 
               
               
                   
                 Uterus Pool 
                 0.1 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.4 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.1 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.1 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.2 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.1 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.1 
               
               
                   
                 Ovary 
                 3.6 
               
               
                   
                 Breast ca. MCF-7 
                 0.5 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.1 
               
               
                   
                 Breast ca. BT 549 
                 2.6 
               
               
                   
                 Breast ca. T47D 
                 0.2 
               
               
                   
                 Breast ca. MDA-N 
                 2.2 
               
               
                   
                 Breast Pool 
                 0.1 
               
               
                   
                 Trachea 
                 1.0 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Fetal Lung 
                 5.6 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.0 
               
               
                   
                 Lung ca. A549 
                 0.0 
               
               
                   
                 Lung ca. NCI-H526 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 0.3 
               
               
                   
                 Lung ca. NCI-H460 
                 0.1 
               
               
                   
                 Lung ca. HOP-62 
                 0.6 
               
               
                   
                 Lung ca. NCI-H522 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 1.3 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
               
               
                   
                 Kidney Pool 
                 0.2 
               
               
                   
                 Fetal Kidney 
                 1.4 
               
               
                   
                 Renal ca. 786-0 
                 0.2 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 4.6 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Bladder 
                 0.6 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.0 
               
               
                   
                 Gastric ca. KATO III 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon cancer tissue 
                 1.2 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 0.2 
               
               
                   
                 Small Intestine Pool 
                 0.2 
               
               
                   
                 Stomach Pool 
                 0.1 
               
               
                   
                 Bone Marrow Pool 
                 0.2 
               
               
                   
                 Fetal Heart 
                 1.0 
               
               
                   
                 Heart Pool 
                 0.3 
               
               
                   
                 Lymph Node Pool 
                 0.4 
               
               
                   
                 Fetal Skeletal Muscle 
                 0.1 
               
               
                   
                 Skeletal Muscle Pool 
                 0.2 
               
               
                   
                 Spleen Pool 
                 1.1 
               
               
                   
                 Thymus Pool 
                 0.6 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.8 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 3.0 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.0 
               
               
                   
                 CNS cancer (astro) SF-539 
                 18.8 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 100.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.8 
               
               
                   
                 Brain (Amygdala) Pool 
                 0.0 
               
               
                   
                 Brain (cerebellum) 
                 0.0 
               
               
                   
                 Brain (fetal) 
                 0.0 
               
               
                   
                 Brain (Hippocampus) Pool 
                 0.0 
               
               
                   
                 Cerebral Cortex Pool 
                 0.0 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 0.0 
               
               
                   
                 Brain (Thalamus) Pool 
                 0.0 
               
               
                   
                 Brain (whole) 
                 0.0 
               
               
                   
                 Spinal Cord Pool 
                 0.1 
               
               
                   
                 Adrenal Gland 
                 0.1 
               
               
                   
                 Pituitary gland Pool 
                 0.1 
               
               
                   
                 Salivary Gland 
                 0.2 
               
               
                   
                 Thyroid (female) 
                 0.1 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.0 
               
               
                   
                 Pancreas Pool 
                 0.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3899, Run 219166475    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AUD 
               
             
            
               
                   
               
               
                   
               
               
                 HASS Panel v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 MCF-7 C1 
                 43.8 
               
               
                   
                 MCF-7 C2 
                 51.4 
               
               
                   
                 MCF-7 C3 
                 11.2 
               
               
                   
                 MCF-7 C4 
                 72.2 
               
               
                   
                 MCF-7 C5 
                 11.0 
               
               
                   
                 MCF-7 C6 
                 43.8 
               
               
                   
                 MCF-7 C7 
                 18.8 
               
               
                   
                 MCF-7 C9 
                 17.3 
               
               
                   
                 MCF-7 C10 
                 100.0 
               
               
                   
                 MCF-7 C11 
                 3.2 
               
               
                   
                 MCF-7 C12 
                 22.1 
               
               
                   
                 MCF-7 C13 
                 26.4 
               
               
                   
                 MCF-7 C15 
                 10.4 
               
               
                   
                 MCF-7 C16 
                 45.1 
               
               
                   
                 MCF-7 C17 
                 22.2 
               
               
                   
                 T24 D1 
                 0.0 
               
               
                   
                 T24 D2 
                 0.0 
               
               
                   
                 T24 D3 
                 0.0 
               
               
                   
                 T24 D4 
                 0.0 
               
               
                   
                 T24 D5 
                 0.1 
               
               
                   
                 T24 D6 
                 0.0 
               
               
                   
                 T24 D7 
                 0.0 
               
               
                   
                 T24 D9 
                 0.0 
               
               
                   
                 T24 D10 
                 0.0 
               
               
                   
                 T24 D11 
                 0.0 
               
               
                   
                 T24 D12 
                 0.0 
               
               
                   
                 T24 D13 
                 0.0 
               
               
                   
                 T24 D15 
                 0.0 
               
               
                   
                 T24 D16 
                 0.0 
               
               
                   
                 T24 D17 
                 0.0 
               
               
                   
                 CAPaN B1 
                 0.0 
               
               
                   
                 CAPaN B2 
                 0.0 
               
               
                   
                 CAPaN B3 
                 0.0 
               
               
                   
                 CAPaN B4 
                 0.0 
               
               
                   
                 CAPaN B5 
                 0.0 
               
               
                   
                 CAPaN B6 
                 0.0 
               
               
                   
                 CAPaN B7 
                 0.0 
               
               
                   
                 CAPaN B8 
                 0.0 
               
               
                   
                 CAPaN B9 
                 0.0 
               
               
                   
                 CAPaN B10 
                 0.0 
               
               
                   
                 CAPaN B11 
                 0.0 
               
               
                   
                 CAPaN B12 
                 0.0 
               
               
                   
                 CAPaN B13 
                 0.0 
               
               
                   
                 CAPaN B14 
                 0.0 
               
               
                   
                 CAPaN B15 
                 0.0 
               
               
                   
                 CAPaN B16 
                 0.0 
               
               
                   
                 CAPaN B17 
                 0.0 
               
               
                   
                 U87-MG F1 (B) 
                 0.2 
               
               
                   
                 U87-MG F2 
                 0.1 
               
               
                   
                 U87-MG F3 
                 0.8 
               
               
                   
                 U87-MG F4 
                 0.4 
               
               
                   
                 U87-MG F5 
                 3.5 
               
               
                   
                 U87-MG F6 
                 1.5 
               
               
                   
                 U87-MG F7 
                 0.6 
               
               
                   
                 U87-MG F8 
                 1.6 
               
               
                   
                 U87-MG F9 
                 0.0 
               
               
                   
                 U87-MG F10 
                 2.2 
               
               
                   
                 U87-MG F11 
                 3.1 
               
               
                   
                 U87-MG F12 
                 1.8 
               
               
                   
                 U87-MG F13 
                 0.7 
               
               
                   
                 U87-MG F14 
                 1.1 
               
               
                   
                 U87-MG F15 
                 0.7 
               
               
                   
                 U87-MG F16 
                 1.4 
               
               
                   
                 U87-MG F17 
                 1.8 
               
               
                   
                 LnCAP A1 
                 0.0 
               
               
                   
                 LnCAP A2 
                 0.0 
               
               
                   
                 LnCAP A3 
                 0.0 
               
               
                   
                 LnCAP A4 
                 0.0 
               
               
                   
                 LnCAP A5 
                 0.0 
               
               
                   
                 LnCAP A6 
                 0.0 
               
               
                   
                 LnCAP A7 
                 0.0 
               
               
                   
                 LnCAP A8 
                 0.0 
               
               
                   
                 LnCAP A9 
                 0.0 
               
               
                   
                 LnCAP A10 
                 0.0 
               
               
                   
                 LnCAP A11 
                 0.0 
               
               
                   
                 LnCAP A12 
                 0.0 
               
               
                   
                 LnCAP A13 
                 0.0 
               
               
                   
                 LnCAP A14 
                 0.0 
               
               
                   
                 LnCAP A15 
                 0.0 
               
               
                   
                 LnCAP A16 
                 0.0 
               
               
                   
                 LnCAP A17 
                 0.0 
               
               
                   
                 Primary Astrocytes 
                 4.9 
               
               
                   
                 Primary Renal Proximal Tubule Epithelial cell A2 
                 0.3 
               
               
                   
                 Primary melanocytes A5 
                 0.4 
               
               
                   
                 126443 - 341 medullo 
                 0.0 
               
               
                   
                 126444 - 487 medullo 
                 0.0 
               
               
                   
                 126445 - 425 medullo 
                 2.7 
               
               
                   
                 126446 - 690 medullo 
                 0.5 
               
               
                   
                 126447 - 54 adult glioma 
                 0.2 
               
               
                   
                 126448 - 245 adult glioma 
                 38.4 
               
               
                   
                 126449 - 317 adult glioma 
                 0.0 
               
               
                   
                 126450 - 212 glioma 
                 0.0 
               
               
                   
                 126451 - 456 glioma 
                 0.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3108, Run 268623842    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AUE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2.1 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 0.7 
               
               
                   
                 Colon cancer (OD06064) 
                 1.3 
               
               
                   
                 Colon cancer margin (OD06064) 
                 0.0 
               
               
                   
                 Colon cancer (OD06159) 
                 0.5 
               
               
                   
                 Colon cancer margin (OD06159) 
                 1.8 
               
               
                   
                 Colon cancer (OD06298-08) 
                 1.6 
               
               
                   
                 Colon cancer margin (OD06298-018) 
                 0.3 
               
               
                   
                 Colon Cancer Gr.2 ascend colon (ODO3921) 
                 1.6 
               
               
                   
                 Colon Cancer margin (ODO3921) 
                 4.6 
               
               
                   
                 Colon cancer metastasis (OD06104) 
                 2.1 
               
               
                   
                 Lung margin (OD06104) 
                 2.8 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 4.5 
               
               
                   
                 Lung margin (OD04451-02) 
                 10.7 
               
               
                   
                 Normal Prostate 
                 0.8 
               
               
                   
                 Prostate Cancer (OD04410) 
                 0.7 
               
               
                   
                 Prostate margin (OD04410) 
                 13.6 
               
               
                   
                 Normal Lung 
                 34.2 
               
               
                   
                 Invasive poor diff. lung adeno 1 (ODO4945-01) 
                 9.2 
               
               
                   
                 Lung margin (ODO4945-03) 
                 6.2 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 11.1 
               
               
                   
                 Lung margin (OD03126) 
                 34.9 
               
               
                   
                 Lung Cancer (OD05014A) 
                 25.2 
               
               
                   
                 Lung margin (OD05014B) 
                 5.6 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 1.5 
               
               
                   
                 Lung margin (OD04237-02) 
                 63.3 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 24.3 
               
               
                   
                 Liver margin (ODO4310) 
                 7.6 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 100.0 
               
               
                   
                 Lung margin (OD04321) 
                 20.2 
               
               
                   
                 Normal Kidney 
                 3.6 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 6.9 
               
               
                   
                 Kidney margin (OD04338) 
                 2.1 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 1.1 
               
               
                   
                 Kidney margin (OD04339) 
                 0.2 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 8.8 
               
               
                   
                 Kidney margin (OD04340) 
                 4.5 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 1.3 
               
               
                   
                 Kidney margin (OD04348) 
                 1.8 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.6 
               
               
                   
                 Kidney margin (OD04450-03) 
                 4.6 
               
               
                   
                 Kidney Cancer 8120613 
                 0.3 
               
               
                   
                 Kidney margin 8120614 
                 0.5 
               
               
                   
                 Kidney Cancer 9010320 
                 0.9 
               
               
                   
                 Kidney margin 9010321 
                 9.5 
               
               
                   
                 Kidney Cancer 8120607 
                 0.6 
               
               
                   
                 Kidney margin 8120608 
                 0.7 
               
               
                   
                 Normal Uterus 
                 1.7 
               
               
                   
                 Uterus Cancer 
                 1.2 
               
               
                   
                 Normal Thyroid 
                 0.1 
               
               
                   
                 Thyroid Cancer 
                 0.9 
               
               
                   
                 Thyroid Cancer A302152 
                 1.2 
               
               
                   
                 Thyroid margin A302153 
                 0.9 
               
               
                   
                 Normal Breast 
                 12.4 
               
               
                   
                 Breast Cancer 
                 0.9 
               
               
                   
                 Breast Cancer 
                 4.3 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 0.6 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 6.6 
               
               
                   
                 Breast Cancer Metastasis 
                 2.1 
               
               
                   
                 Breast Cancer 
                 3.3 
               
               
                   
                 Breast Cancer 9100266 
                 4.6 
               
               
                   
                 Breast margin 9100265 
                 1.5 
               
               
                   
                 Breast Cancer A209073 
                 2.5 
               
               
                   
                 Breast margin A2090734 
                 9.9 
               
               
                   
                 Normal Liver 
                 4.2 
               
               
                   
                 Liver Cancer 1026 
                 1.8 
               
               
                   
                 Liver Cancer 1025 
                 6.1 
               
               
                   
                 Liver Cancer 6004-T 
                 3.5 
               
               
                   
                 Liver Tissue 6004-N 
                 0.8 
               
               
                   
                 Liver Cancer 6005-T 
                 14.2 
               
               
                   
                 Liver Tissue 6005-N 
                 14.8 
               
               
                   
                 Liver Cancer 
                 1.4 
               
               
                   
                 Normal Bladder 
                 1.7 
               
               
                   
                 Bladder Cancer 
                 1.8 
               
               
                   
                 Bladder Cancer 
                 2.4 
               
               
                   
                 Normal Ovary 
                 7.7 
               
               
                   
                 Ovarian Cancer 
                 13.6 
               
               
                   
                 Ovarian cancer (OD06145) 
                 0.6 
               
               
                   
                 Ovarian cancer margin (OD06145) 
                 2.2 
               
               
                   
                 Normal Stomach 
                 4.1 
               
               
                   
                 Gastric Cancer 9060397 
                 1.2 
               
               
                   
                 Stomach margin 9060396 
                 0.5 
               
               
                   
                 Gastric Cancer 9060395 
                 7.4 
               
               
                   
                 Stomach margin 9060394 
                 2.6 
               
               
                   
                 Gastric Cancer 064005 
                 4.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3108, Run 170686074    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AUF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 0.3 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.0 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 3.2 
               
               
                   
                 HUVEC starved 
                 8.1 
               
               
                   
                 HUVEC IL-1beta 
                 4.1 
               
               
                   
                 HUVEC IFN gamma 
                 15.8 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 1.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 2.9 
               
               
                   
                 HUVEC IL-11 
                 4.2 
               
               
                   
                 Lung Microvascular EC none 
                 1.5 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.4 
               
               
                   
                 Small airway epithelium none 
                 0.0 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Coronery artery SMC rest 
                 8.5 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 1.8 
               
               
                   
                 Astrocytes rest 
                 0.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 0.5 
               
               
                   
                 KU-812 (Basophil) rest 
                 1.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 8.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Liver cirrhosis 
                 7.6 
               
               
                   
                 NCI-H292 none 
                 0.0 
               
               
                   
                 NCI-H292 IL-4 
                 0.0 
               
               
                   
                 NCI-H292 IL-9 
                 0.0 
               
               
                   
                 NCI-H292 IL-13 
                 0.0 
               
               
                   
                 NCI-H292 IFN gamma 
                 0.0 
               
               
                   
                 HPAEC none 
                 17.9 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 11.3 
               
               
                   
                 Lung fibroblast none 
                 3.4 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 2.7 
               
               
                   
                 Lung fibroblast IL-4 
                 4.4 
               
               
                   
                 Lung fibroblast IL-9 
                 2.2 
               
               
                   
                 Lung fibroblast IL-13 
                 3.9 
               
               
                   
                 Lung fibroblast IFN gamma 
                 7.2 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 5.5 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 1.9 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 1.5 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 29.5 
               
               
                   
                 Dermal fibroblast IL-4 
                 75.8 
               
               
                   
                 Dermal Fibroblasts rest 
                 21.5 
               
               
                   
                 Neutrophils TNFa + LPS 
                 0.0 
               
               
                   
                 Neutrophils rest 
                 0.0 
               
               
                   
                 Colon 
                 2.0 
               
               
                   
                 Lung 
                 100.0 
               
               
                   
                 Thymus 
                 0.5 
               
               
                   
                 Kidney 
                 3.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3899, Run 170120166    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AUG 
               
             
            
               
                   
               
               
                   
               
               
                 general oncology screening panel_v_2.4 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Colon cancer 1 
                 13.9 
                 10.8 
               
               
                   
                 Colon NAT 1 
                 7.3 
                 4.5 
               
               
                   
                 Colon cancer 2 
                 2.3 
                 5.2 
               
               
                   
                 Colon NAT 2 
                 1.1 
                 0.8 
               
               
                   
                 Colon cancer 3 
                 14.1 
                 11.7 
               
               
                   
                 Colon NAT 3 
                 16.6 
                 4.2 
               
               
                   
                 Colon malignant cancer 4 
                 14.1 
                 9.9 
               
               
                   
                 Colon NAT 4 
                 0.3 
                 0.3 
               
               
                   
                 Lung cancer 1 
                 8.2 
                 18.3 
               
               
                   
                 Lung NAT 1 
                 0.0 
                 0.4 
               
               
                   
                 Lung cancer 2 
                 96.6 
                 47.0 
               
               
                   
                 Lung NAT 2 
                 1.4 
                 2.4 
               
               
                   
                 Squamous cell carcinoma 3 
                 50.0 
                 22.2 
               
               
                   
                 Lung NAT 3 
                 0.6 
                 0.7 
               
               
                   
                 Metastatic melanoma 1 
                 1.5 
                 3.7 
               
               
                   
                 Melanoma 2 
                 0.0 
                 0.2 
               
               
                   
                 Melanoma 3 
                 0.0 
                 0.5 
               
               
                   
                 Metastatic melanoma 4 
                 100.0 
                 100.0 
               
               
                   
                 Metastatic melanoma 5 
                 95.3 
                 47.3 
               
               
                   
                 Bladder cancer 1 
                 0.0 
                 0.0 
               
               
                   
                 Bladder NAT 1 
                 0.0 
                 0.0 
               
               
                   
                 Bladder cancer 2 
                 0.0 
                 0.2 
               
               
                   
                 Bladder NAT 2 
                 0.0 
                 0.0 
               
               
                   
                 Bladder NAT 3 
                 0.0 
                 0.0 
               
               
                   
                 Bladder NAT 4 
                 1.3 
                 1.1 
               
               
                   
                 Prostate adenocarcinoma 1 
                 1.2 
                 7.2 
               
               
                   
                 Prostate adenocarcinoma 2 
                 0.3 
                 0.9 
               
               
                   
                 Prostate adenocarcinoma 3 
                 1.3 
                 0.8 
               
               
                   
                 Prostate adenocarcinoma 4 
                 11.8 
                 5.8 
               
               
                   
                 Prostate NAT 5 
                 5.7 
                 1.7 
               
               
                   
                 Prostate adenocarcinoma 6 
                 0.3 
                 0.8 
               
               
                   
                 Prostate adenocarcinoma 7 
                 1.0 
                 1.6 
               
               
                   
                 Prostate adenocarcinoma 8 
                 0.4 
                 0.7 
               
               
                   
                 Prostate adenocarcinoma 9 
                 23.3 
                 41.5 
               
               
                   
                 Prostate NAT 10 
                 0.0 
                 0.0 
               
               
                   
                 Kidney cancer 1 
                 48.3 
                 7.0 
               
               
                   
                 Kidney NAT 1 
                 4.5 
                 1.8 
               
               
                   
                 Kidney cancer 2 
                 40.6 
                 29.5 
               
               
                   
                 Kidney NAT 2 
                 9.0 
                 11.3 
               
               
                   
                 Kidney cancer 3 
                 25.3 
                 11.5 
               
               
                   
                 Kidney NAT 3 
                 1.5 
                 2.7 
               
               
                   
                 Kidney cancer 4 
                 40.1 
                 11.2 
               
               
                   
                 Kidney NAT 4 
                 2.3 
                 1.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3108, Run 259737911    
               
               
                   
                   Column B - Rel. Exp. (%) Ag3899, Run 268143635    
               
            
           
         
       
     
      General_screening_panel_v1.4 Summary: Ag3899 Highest expression of this gene was detected in an astrocytoma SNB-75 cell line (CT=23.8). High levels of expression of this gene are also seen in a cluster of brain and melanoma cancer cell lines. Expression of this gene is useful as a marker to distinguish these samples from other samples in the panel and also as marker for detection of these cancers. Therapeutic modulation of the activity of this gene or its protein product, through the use of small molecule drugs, protein therapeutics or antibodies, is beneficial in the treatment of these cancers.  
      Among tissues with metabolic or endocrine function, this gene was expressed at low to moderate levels in pancreas, adipose, adrenal gland, thyroid, pituitary gland, skeletal muscle, heart, liver and the gastrointestinal tract. Therapeutic modulation of the activity of this gene or its gene product is useful in the treatment of endocrine/metabolically related diseases, such as obesity and diabetes.  
      This gene was expressed at much higher levels in fetal liver (CT=30) and lung (CTs=27.9) when compared to corresponding adult liver (CT=35) and lung (CT=36.8). Expression of this gene or ists protein product is of use as a marker to distinguish these fetal tissues from the corresponding adult tissues.  
      HASS Panel v1.0 Summary: Ag3108 This gene was expressed by MCF-7 cells and a glioma sample on this panel. Expression of this gene was serum-dependent in MCF-7 cells. Expression is regulated by cytokines and extracellular molecules found in serum. Modulation of this gene, through the use of small molecule drugs, protein therapeutics or antibodies is of benefit in the treatment of glioma.  
      Panel 2.1 Summary: Ag3108 Highest expression of this gene was detected in a melanoma metastasis sample (CT=29). Expression of this gene was higher in normal liver when compared to adjancent cancerous tissue and in metastasic breast cancer tissue (OD04590-03) (CT=33) as compared to primary breast cancer (OD04590-01) (CT=36.7). Expression of this gene is useful as a marker for cancer metastasis. Therapeutic modulation of the expression or function of this gene or gene product is useful in the treatment of lung, breast and melanoma cancers.  
      Panel 4.1D Summary: Ag3108 Highest expression of this gene was seen in lung (CT=28.6). Significant expression of this gene was also seen in HPAEC cells, HUVEC cells, lung fibroblast, TNFalpha+IL1 beta treated bronchial epithelium and dermal fibroblasts. Antibody, protein therapeutics or small molecule therapies designed with the protein encoded for by this gene are important in the treatment of inflammatory lung disorders such as chronic obstructive pulmonary disease, asthma, allergy and emphysema and skin disorders including psoriasis.  
      In addition, low expression of this gene was also seen in kidney and colon. Antibody, protein therapeutics or small molecule therapies designed with the protein encoded by this gene are important in the treatment of inflammatory or autoimmune diseases that affect the kidney, including lupus and glomerulonephritis, as well as, inflammatory bowel diseases such as Crohns.  
      Expression of this gene was stimulated in PMA/ionomycin treated basophils (CT=30) as compared to resting basophils (CT=36). Basophils release histamines and other biological modifiers in reponse to allergens and play an important role in the pathology of asthma and hypersensitivity reactions. Therapeutics designed against the protein encoded by this gene are useful for the reduction or inhibition of inflammation by blocking basophil function in these diseases. These cells are a reasonable model for the inflammatory cells that take part in various inflammatory lung and bowel diseases, such as asthma, Crohn&#39;s disease, and ulcerative colitis. Therapeutics that modulate the function of this gene or gene product are useful for the reduction or elimination of the symptoms of patients suffering from asthma, Crohn&#39;s disease, and ulcerative colitis.  
      general oncology screening panel_V — 2.4 Summary: Ag3108/Ag3960 Highest expression of this gene was seen in a metastatic melanoma sample (CTs=30-31). Expression of this gene was higher in kidney and lung cancer when compared to normal adjacent tissue samples. Expression of this gene is useful as a marker to differentiate these samples from other samples on this panel and as a marker for these cancers. Therapeutic modulation of the expression or function of this gene or gene product is of use in the treatment of these cancers.  
      AV. CG56959-02: Synaptotagmin X  
      Expression of full-length physical clone CG56959-02 was assessed using the primer-probe set Ag1557, described in Table AVA. Results of the RTQ-PCR runs are shown in Tables AVB, AVC, AVD and AVE.  
               TABLE AVA                          Probe Name Ag1557                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-gcgtgcacagaaagactttaaa-3′   22   698   1519                   Probe   TET-5′-tgatgaaacttttcaatttcctgtagca-3′-   28   661   1520           TAMRA               Reverse   5′-tgaaatgtagttttcggttgct-3′   22   627   1521                  
 
     
       
         
           
               
             
               
                 TABLE AVB 
               
             
            
               
                   
               
               
                   
               
               
                 AI_comprehensive panel_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 110967 COPD-F 
                 0.0 
               
               
                   
                 110980 COPD-F 
                 0.0 
               
               
                   
                 110968 COPD-M 
                 0.0 
               
               
                   
                 110977 COPD-M 
                 0.0 
               
               
                   
                 110989 Emphysema-F 
                 0.0 
               
               
                   
                 110992 Emphysema-F 
                 0.0 
               
               
                   
                 110993 Emphysema-F 
                 0.0 
               
               
                   
                 110994 Emphysema-F 
                 0.0 
               
               
                   
                 110995 Emphysema-F 
                 0.8 
               
               
                   
                 110996 Emphysema-F 
                 0.0 
               
               
                   
                 110997 Asthma-M 
                 2.6 
               
               
                   
                 111001 Asthma-F 
                 0.0 
               
               
                   
                 111002 Asthma-F 
                 0.0 
               
               
                   
                 111003 Atopic Asthma-F 
                 0.0 
               
               
                   
                 111004 Atopic Asthma-F 
                 0.0 
               
               
                   
                 111005 Atopic Asthma-F 
                 0.0 
               
               
                   
                 111006 Atopic Asthma-F 
                 0.0 
               
               
                   
                 111417 Allergy-M 
                 0.0 
               
               
                   
                 112347 Allergy-M 
                 2.4 
               
               
                   
                 112349 Normal Lung-F 
                 2.4 
               
               
                   
                 112357 Normal Lung-F 
                 2.1 
               
               
                   
                 112354 Normal Lung-M 
                 0.0 
               
               
                   
                 112374 Crohns-F 
                 23.8 
               
               
                   
                 112389 Match Control Crohns-F 
                 7.0 
               
               
                   
                 112375 Crohns-F 
                 32.1 
               
               
                   
                 112732 Match Control Crohns-F 
                 0.0 
               
               
                   
                 112725 Crohns-M 
                 11.7 
               
               
                   
                 112387 Match Control Crohns-M 
                 0.0 
               
               
                   
                 112378 Crohns-M 
                 5.0 
               
               
                   
                 112390 Match Control Crohns-M 
                 1.3 
               
               
                   
                 112726 Crohns-M 
                 26.1 
               
               
                   
                 112731 Match Control Crohns-M 
                 67.8 
               
               
                   
                 112380 Ulcer Col-F 
                 0.0 
               
               
                   
                 112734 Match Control Ulcer Col-F 
                 0.0 
               
               
                   
                 112384 Ulcer Col-F 
                 1.1 
               
               
                   
                 112737 Match Control Ulcer Col-F 
                 12.9 
               
               
                   
                 112386 Ulcer Col-F 
                 0.0 
               
               
                   
                 112738 Match Control Ulcer Col-F 
                 0.9 
               
               
                   
                 112381 Ulcer Col-M 
                 9.4 
               
               
                   
                 112735 Match Control Ulcer Col-M 
                 62.4 
               
               
                   
                 112382 Ulcer Col-M 
                 4.5 
               
               
                   
                 112394 Match Control Ulcer Col-M 
                 0.0 
               
               
                   
                 112383 Ulcer Col-M 
                 0.7 
               
               
                   
                 112736 Match Control Ulcer Col-M 
                 2.1 
               
               
                   
                 112423 Psoriasis-F 
                 1.6 
               
               
                   
                 112427 Match Control Psoriasis-F 
                 2.7 
               
               
                   
                 112418 Psoriasis-M 
                 0.0 
               
               
                   
                 112723 Match Control Psoriasis-M 
                 4.4 
               
               
                   
                 112419 Psoriasis-M 
                 5.8 
               
               
                   
                 112424 Match Control Psoriasis-M 
                 2.3 
               
               
                   
                 112420 Psoriasis-M 
                 1.3 
               
               
                   
                 112425 Match Control Psoriasis-M 
                 0.0 
               
               
                   
                 104689 (MF) OA Bone-Backus 
                 0.0 
               
               
                   
                 104690 (MF) Adj “Normal” Bone-Backus 
                 0.8 
               
               
                   
                 104691 (MF) OA Synovium-Backus 
                 0.0 
               
               
                   
                 104692 (BA) OA Cartilage-Backus 
                 0.0 
               
               
                   
                 104694 (BA) OA Bone-Backus 
                 0.8 
               
               
                   
                 104695 (BA) Adj “Normal” Bone-Backus 
                 0.0 
               
               
                   
                 104696 (BA) OA Synovium-Backus 
                 1.1 
               
               
                   
                 104700 (SS) OA Bone-Backus 
                 0.0 
               
               
                   
                 104701 (SS) Adj “Normal” Bone-Backus 
                 0.0 
               
               
                   
                 104702 (SS) OA Synovium-Backus 
                 0.9 
               
               
                   
                 117093 OA Cartilage Rep7 
                 0.0 
               
               
                   
                 112672 OA Bone5 
                 9.4 
               
               
                   
                 112673 OA Synovium5 
                 0.9 
               
               
                   
                 112674 OA Synovial Fluid cells5 
                 2.8 
               
               
                   
                 117100 OA Cartilage Rep14 
                 0.0 
               
               
                   
                 112756 OA Bone9 
                 100.0 
               
               
                   
                 112757 OA Synovium9 
                 0.0 
               
               
                   
                 112758 OA Synovial Fluid Cells9 
                 0.0 
               
               
                   
                 117125 RA Cartilage Rep2 
                 0.0 
               
               
                   
                 113492 Bone2 RA 
                 0.0 
               
               
                   
                 113493 Synovium2 RA 
                 0.0 
               
               
                   
                 113494 Syn Fluid Cells RA 
                 0.6 
               
               
                   
                 113499 Cartilage4 RA 
                 0.0 
               
               
                   
                 113500 Bone4 RA 
                 0.0 
               
               
                   
                 113501 Synovium4 RA 
                 1.6 
               
               
                   
                 113502 Syn Fluid Cells4 RA 
                 0.0 
               
               
                   
                 113495 Cartilage3 RA 
                 1.6 
               
               
                   
                 113496 Bone3 RA 
                 0.0 
               
               
                   
                 113497 Synovium3 RA 
                 2.1 
               
               
                   
                 113498 Syn Fluid Cells3 RA 
                 0.0 
               
               
                   
                 117106 Normal Cartilage Rep20 
                 0.0 
               
               
                   
                 113663 Bone3 Normal 
                 6.5 
               
               
                   
                 113664 Synovium3 Normal 
                 1.4 
               
               
                   
                 113665 Syn Fluid Cells3 Normal 
                 5.8 
               
               
                   
                 117107 Normal Cartilage Rep22 
                 0.0 
               
               
                   
                 113667 Bone4 Normal 
                 0.0 
               
               
                   
                 113668 Synovium4 Normal 
                 0.0 
               
               
                   
                 113669 Syn Fluid Cells4 Normal 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1557, Run 257809393    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AVC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 0.0 
                 0.0 
               
               
                   
                 Pancreas 
                 0.0 
                 4.9 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
                 0.0 
               
               
                   
                 Adrenal gland 
                 2.0 
                 0.0 
               
               
                   
                 Thyroid 
                 0.0 
                 0.0 
               
               
                   
                 Salivary gland 
                 0.0 
                 0.0 
               
               
                   
                 Pituitary gland 
                 68.3 
                 60.7 
               
               
                   
                 Brain (fetal) 
                 0.0 
                 0.0 
               
               
                   
                 Brain (whole) 
                 43.8 
                 34.6 
               
               
                   
                 Brain (amygdala) 
                 8.9 
                 13.8 
               
               
                   
                 Brain (cerebellum) 
                 0.0 
                 0.0 
               
               
                   
                 Brain (hippocampus) 
                 35.6 
                 70.7 
               
               
                   
                 Brain (substantia nigra) 
                 2.1 
                 0.0 
               
               
                   
                 Brain (thalamus) 
                 6.8 
                 18.9 
               
               
                   
                 Cerebral Cortex 
                 98.6 
                 100.0 
               
               
                   
                 Spinal cord 
                 21.5 
                 13.2 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 10.3 
                 12.4 
               
               
                   
                 glioma SNB-19 
                 0.0 
                 0.0 
               
               
                   
                 glioma U251 
                 1.6 
                 0.0 
               
               
                   
                 glioma SF-295 
                 0.0 
                 0.0 
               
               
                   
                 Heart (fetal) 
                 1.6 
                 0.0 
               
               
                   
                 Heart 
                 0.0 
                 0.0 
               
               
                   
                 Skeletal muscle (fetal) 
                 0.0 
                 0.0 
               
               
                   
                 Skeletal muscle 
                 0.0 
                 0.0 
               
               
                   
                 Bone marrow 
                 0.0 
                 0.0 
               
               
                   
                 Thymus 
                 0.0 
                 0.0 
               
               
                   
                 Spleen 
                 0.0 
                 0.0 
               
               
                   
                 Lymph node 
                 0.0 
                 0.0 
               
               
                   
                 Colorectal 
                 5.6 
                 9.7 
               
               
                   
                 Stomach 
                 15.5 
                 12.9 
               
               
                   
                 Small intestine 
                 22.2 
                 50.3 
               
               
                   
                 Colon ca. SW480 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 3.7 
                 2.4 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HCC-2998 
                 0.0 
                 0.0 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.0 
                 0.0 
               
               
                   
                 Bladder 
                 0.0 
                 7.8 
               
               
                   
                 Trachea 
                 2.6 
                 3.8 
               
               
                   
                 Kidney 
                 2.4 
                 18.4 
               
               
                   
                 Kidney (fetal) 
                 0.0 
                 7.7 
               
               
                   
                 Renal ca. 786-0 
                 2.3 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
                 0.0 
               
               
                   
                 Liver 
                 1.8 
                 8.0 
               
               
                   
                 Liver (fetal) 
                 0.0 
                 0.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
                 0.0 
               
               
                   
                 Lung 
                 0.0 
                 0.0 
               
               
                   
                 Lung (fetal) 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 1.9 
                 5.9 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 5.3 
                 0.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
                 0.0 
               
               
                   
                 Mammary gland 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 100.0 
                 62.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 3.5 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
                 0.0 
               
               
                   
                 Ovary 
                 0.0 
                 9.7 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 41.5 
                 23.7 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.0 
                 0.0 
               
               
                   
                 Uterus 
                 4.2 
                 4.6 
               
               
                   
                 Placenta 
                 0.0 
                 0.0 
               
               
                   
                 Prostate 
                 7.2 
                 11.2 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 0.0 
                 0.0 
               
               
                   
                 Testis 
                 13.3 
                 11.1 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma M14 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
                 0.0 
               
               
                   
                 Adipose 
                 0.0 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1557, Run 146380320    
               
               
                   
                   Column B - Rel. Exp. (%) Ag1557, Run 149871705    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AVD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Normal Colon 
                 22.5 
                 51.4 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 0.0 
                 2.1 
               
               
                   
                 CC Margin (ODO3866) 
                 9.0 
                 17.6 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 0.0 
                 0.0 
               
               
                   
                 CC Margin (ODO3868) 
                 3.7 
                 10.3 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 0.0 
                 0.0 
               
               
                   
                 CC Margin (ODO3920) 
                 6.8 
                 15.6 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 9.6 
                 11.8 
               
               
                   
                 CC Margin (ODO3921) 
                 4.6 
                 6.3 
               
               
                   
                 CC from Partial Hepatectomy 
                 0.0 
                 1.2 
               
               
                   
                 (ODO4309) Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 2.3 
                 1.2 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 0.0 
                 2.1 
               
               
                   
                 Lung Margin (OD04451-02) 
                 0.0 
                 0.0 
               
               
                   
                 Normal Prostate 6546-1 
                 8.2 
                 8.2 
               
               
                   
                 Prostate Cancer (OD04410) 
                 2.3 
                 5.8 
               
               
                   
                 Prostate Margin (OD04410) 
                 13.8 
                 16.6 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 7.2 
                 14.9 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 54.0 
                 60.3 
               
               
                   
                 Normal Lung 061010 
                 4.3 
                 0.0 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 0.0 
                 2.6 
               
               
                   
                 Muscle Margin (ODO4286) 
                 0.0 
                 0.0 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 0.0 
                 0.0 
               
               
                   
                 Lung Margin (OD03126) 
                 2.0 
                 2.4 
               
               
                   
                 Lung Cancer (OD04404) 
                 0.0 
                 0.0 
               
               
                   
                 Lung Margin (OD04404) 
                 0.0 
                 0.0 
               
               
                   
                 Lung Cancer (OD04565) 
                 0.0 
                 0.0 
               
               
                   
                 Lung Margin (OD04565) 
                 0.0 
                 0.0 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 51.1 
                 51.1 
               
               
                   
                 Lung Margin (OD04237-02) 
                 0.0 
                 1.4 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 0.0 
                 0.0 
               
               
                   
                 Liver Margin (ODO4310) 
                 3.5 
                 6.3 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.0 
                 0.0 
               
               
                   
                 Lung Margin (OD04321) 
                 0.0 
                 2.7 
               
               
                   
                 Normal Kidney 
                 87.7 
                 76.8 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 4.7 
                 8.8 
               
               
                   
                 Kidney Margin (OD04338) 
                 18.9 
                 19.2 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 14.7 
                 14.6 
               
               
                   
                 Kidney Margin (OD04339) 
                 14.5 
                 13.3 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04340) 
                 21.0 
                 15.0 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04348) 
                 13.1 
                 22.4 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 3.0 
                 9.4 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.0 
                 0.0 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 20.4 
                 31.4 
               
               
                   
                 Kidney Cancer 8120607 
                 3.7 
                 7.7 
               
               
                   
                 Kidney Margin 8120608 
                 1.8 
                 3.0 
               
               
                   
                 Kidney Cancer 8120613 
                 100.0 
                 100.0 
               
               
                   
                 Kidney Margin 8120614 
                 2.0 
                 1.4 
               
               
                   
                 Kidney Cancer 9010320 
                 3.0 
                 5.0 
               
               
                   
                 Kidney Margin 9010321 
                 2.3 
                 1.5 
               
               
                   
                 Normal Uterus 
                 0.0 
                 0.0 
               
               
                   
                 Uterus Cancer 064011 
                 0.0 
                 0.0 
               
               
                   
                 Normal Thyroid 
                 0.0 
                 0.0 
               
               
                   
                 Thyroid Cancer 064010 
                 1.0 
                 0.0 
               
               
                   
                 Thyroid Cancer A302152 
                 0.0 
                 0.0 
               
               
                   
                 Thyroid Margin A302153 
                 0.0 
                 0.0 
               
               
                   
                 Normal Breast 
                 2.1 
                 0.0 
               
               
                   
                 Breast Cancer (OD04566) 
                 0.0 
                 0.0 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 0.0 
                 0.0 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 1.4 
                 0.0 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 1.9 
                 2.1 
               
               
                   
                 Breast Cancer 064006 
                 41.2 
                 0.0 
               
               
                   
                 Breast Cancer 1024 
                 0.0 
                 0.0 
               
               
                   
                 Breast Cancer 9100266 
                 1.3 
                 0.8 
               
               
                   
                 Breast Margin 9100265 
                 0.0 
                 0.0 
               
               
                   
                 Breast Cancer A209073 
                 8.0 
                 8.3 
               
               
                   
                 Breast Margin A209073 
                 1.6 
                 1.3 
               
               
                   
                 Normal Liver 
                 8.5 
                 15.0 
               
               
                   
                 Liver Cancer 064003 
                 1.5 
                 2.3 
               
               
                   
                 Liver Cancer 1025 
                 3.4 
                 6.4 
               
               
                   
                 Liver Cancer 1026 
                 0.0 
                 1.7 
               
               
                   
                 Liver Cancer 6004-T 
                 7.1 
                 2.0 
               
               
                   
                 Liver Tissue 6004-N 
                 0.0 
                 0.0 
               
               
                   
                 Liver Cancer 6005-T 
                 0.0 
                 2.0 
               
               
                   
                 Liver Tissue 6005-N 
                 1.5 
                 4.9 
               
               
                   
                 Normal Bladder 
                 1.9 
                 4.5 
               
               
                   
                 Bladder Cancer 1023 
                 14.0 
                 19.6 
               
               
                   
                 Bladder Cancer A302173 
                 2.9 
                 9.4 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 50.7 
                 74.2 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 0.0 
                 0.0 
               
               
                   
                 Normal Ovary 
                 1.5 
                 2.6 
               
               
                   
                 Ovarian Cancer 064008 
                 1.2 
                 0.0 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 0.0 
                 0.0 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 0.0 
                 0.0 
               
               
                   
                 Normal Stomach 
                 13.8 
                 15.3 
               
               
                   
                 Gastric Cancer 9060358 
                 1.6 
                 0.0 
               
               
                   
                 Stomach Margin 9060359 
                 6.7 
                 8.4 
               
               
                   
                 Gastric Cancer 9060395 
                 1.4 
                 1.2 
               
               
                   
                 Stomach Margin 9060394 
                 2.5 
                 9.0 
               
               
                   
                 Gastric Cancer 9060397 
                 0.0 
                 0.0 
               
               
                   
                 Stomach Margin 9060396 
                 0.0 
                 0.0 
               
               
                   
                 Gastric Cancer 064005 
                 2.1 
                 8.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1557, Run 148394031    
               
               
                   
                   Column B - Rel. Exp. (%) Ag1557, Run 149871817    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AVE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.0 
               
               
                   
                 LAK cells IL-2 
                 1.8 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.0 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 3.6 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 2.7 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
               
               
                   
                 Small airway epithelium none 
                 3.6 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Coronery artery SMC rest 
                 0.0 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Astrocytes rest 
                 0.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Liver cirrhosis 
                 5.2 
               
               
                   
                 Lupus kidney 
                 1.9 
               
               
                   
                 NCI-H292 none 
                 1.6 
               
               
                   
                 NCI-H292 IL-4 
                 1.6 
               
               
                   
                 NCI-H292 IL-9 
                 0.0 
               
               
                   
                 NCI-H292 IL-13 
                 0.0 
               
               
                   
                 NCI-H292 IFN gamma 
                 0.0 
               
               
                   
                 HPAEC none 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 0.0 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast IL-4 
                 0.0 
               
               
                   
                 Lung fibroblast IL-9 
                 0.0 
               
               
                   
                 Lung fibroblast IL-13 
                 0.0 
               
               
                   
                 Lung fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 0.0 
               
               
                   
                 IBD Colitis 2 
                 7.3 
               
               
                   
                 IBD Crohn&#39;s 
                 4.0 
               
               
                   
                 Colon 
                 28.1 
               
               
                   
                 Lung 
                 2.0 
               
               
                   
                 Thymus 
                 100.0 
               
               
                   
                 Kidney 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1557, Run 149871968    
               
            
           
         
       
     
      AI_comprehensive panel_v1.0 Summary: Ag1557 Low but significant expression was seen in an OA bone sample (CT=32). Prominent expression was also detected in ulcerative colitis and Crohn&#39;s samples as well as adjacent normal tissue samples.  
      Panel 1.3D Summary: Ag1557 Highest expression of this gene was detected in a breast cancer cell line and the cerebral cortex (CTs=33-34.6). Expression of this gene is of use as a marker for breast cancer. This gene was also expressed at moderate levels in the pituitary gland. The protein encoded by this gene is homologous to synaptotagmin and is important in the pituitary secretory pathway. This gene product or antibodies or small molecules that target this gene product are useful in the treatment of disease in this tissue.  
      Panel 2D Summary: Ag1557 Increased expression of this gene was seen in a single kidney sample (CTs=33), lung cancer sample and bladder cancer sample compared to the expression in the normal adjacent tissues showing that expression of this gene or gene product is of use as a marker to distinguish cancer from normal adjacent tissue. Therapeutic inhibition of this gene activity, through the use of small molecule drugs, protein therapeutics or antibodies, is of utility in the treatment of lung, bladder and kidney cancers.  
      Panel 4D Summary: Ag1557 This gene was expressed at a moderate level (CT=33.39) in thymus (Panel 4D). Small molecule drugs, protein therapeutics, or antibodies that inhibit the function of this synaptotagmin-like protein are useful for the reduction or elimination of the symptoms of autoimmune or inflammatory diseases that depend on the T cells that develop in the thymus, such as asthma, allergies, inflammatory bowel disease, lupus erythematosus, or rheumatoid arthritis.  
      AW. CG57111-01: Protocadherin  
      Expression of gene CG571 11-01 was assessed using the primer-probe sets Ag1096 and Ag3242, described in Tables AWA and AWB. Results of the RTQ-PCR runs are shown in Tables AWC, AWD, AWE, and AWF.  
               TABLE AWA                          Probe Name Ag1096                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-actttggaagaggcattgct-3′   20   2403   1522                   Probe   TET-5′-cagacagattatgggctccatcgctt-3′-   26   2424   1523           TAMRA               Reverse   5′-ctcgggataaccatgatcact-3′   21   2463   1524                  
 
     
       
         
           
               
             
               
                 TABLE AWB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag3242 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-gggaccaatgctcaaattactt-3′ 
                 22 
                 1038 
                 1525 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-tcagaaagttccacaagcatctaagga-3′- 
                 27 
                 1070 
                 1526 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-atgactccagtgttttcatcca-3′ 
                 22 
                 1108 
                 1527 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AWC 
               
             
            
               
                   
               
               
                   
               
               
                 AI_comprehensive panel_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 110967 COPD-F 
                 28.9 
               
               
                   
                 110980 COPD-F 
                 6.7 
               
               
                   
                 110968 COPD-M 
                 19.9 
               
               
                   
                 110977 COPD-M 
                 8.4 
               
               
                   
                 110989 Emphysema-F 
                 49.3 
               
               
                   
                 110992 Emphysema-F 
                 22.8 
               
               
                   
                 110993 Emphysema-F 
                 31.0 
               
               
                   
                 110994 Emphysema-F 
                 12.7 
               
               
                   
                 110995 Emphysema-F 
                 25.5 
               
               
                   
                 110996 Emphysema-F 
                 15.8 
               
               
                   
                 110997 Asthma-M 
                 7.5 
               
               
                   
                 111001 Asthma-F 
                 30.4 
               
               
                   
                 111002 Asthma-F 
                 45.4 
               
               
                   
                 111003 Atopic Asthma-F 
                 45.1 
               
               
                   
                 111004 Atopic Asthma-F 
                 22.4 
               
               
                   
                 111005 Atopic Asthma-F 
                 25.3 
               
               
                   
                 111006 Atopic Asthma-F 
                 13.9 
               
               
                   
                 111417 Allergy-M 
                 15.1 
               
               
                   
                 112347 Allergy-M 
                 5.0 
               
               
                   
                 112349 Normal Lung-F 
                 1.9 
               
               
                   
                 112357 Normal Lung-F 
                 5.1 
               
               
                   
                 112354 Normal Lung-M 
                 11.6 
               
               
                   
                 112374 Crohns-F 
                 32.5 
               
               
                   
                 112389 Match Control Crohns-F 
                 14.4 
               
               
                   
                 112375 Crohns-F 
                 36.1 
               
               
                   
                 112732 Match Control Crohns-F 
                 0.0 
               
               
                   
                 112725 Crohns-M 
                 45.4 
               
               
                   
                 112387 Match Control Crohns-M 
                 18.3 
               
               
                   
                 112378 Crohns-M 
                 3.8 
               
               
                   
                 112390 Match Control Crohns-M 
                 22.4 
               
               
                   
                 112726 Crohns-M 
                 45.7 
               
               
                   
                 112731 Match Control Crohns-M 
                 12.6 
               
               
                   
                 112380 Ulcer Col-F 
                 28.3 
               
               
                   
                 112734 Match Control Ulcer Col-F 
                 0.8 
               
               
                   
                 112384 Ulcer Col-F 
                 100.0 
               
               
                   
                 112737 Match Control Ulcer Col-F 
                 28.1 
               
               
                   
                 112386 Ulcer Col-F 
                 25.5 
               
               
                   
                 112738 Match Control Ulcer Col-F 
                 2.1 
               
               
                   
                 112381 Ulcer Col-M 
                 2.3 
               
               
                   
                 112735 Match Control Ulcer Col-M 
                 53.6 
               
               
                   
                 112382 Ulcer Col-M 
                 15.3 
               
               
                   
                 112394 Match Control Ulcer Col-M 
                 10.2 
               
               
                   
                 112383 Ulcer Col-M 
                 45.4 
               
               
                   
                 112736 Match Control Ulcer Col-M 
                 4.0 
               
               
                   
                 112423 Psoriasis-F 
                 90.1 
               
               
                   
                 112427 Match Control Psoriasis-F 
                 55.9 
               
               
                   
                 112418 Psoriasis-M 
                 25.7 
               
               
                   
                 112723 Match Control Psoriasis-M 
                 0.0 
               
               
                   
                 112419 Psoriasis-M 
                 66.0 
               
               
                   
                 112424 Match Control Psoriasis-M 
                 42.0 
               
               
                   
                 112420 Psoriasis-M 
                 44.4 
               
               
                   
                 112425 Match Control Psoriasis-M 
                 24.3 
               
               
                   
                 104689 (MF) OA Bone-Backus 
                 81.2 
               
               
                   
                 104690 (MF) Adj “Normal” Bone-Backus 
                 16.6 
               
               
                   
                 104691 (MF) OA Synovium-Backus 
                 1.5 
               
               
                   
                 104692 (BA) OA Cartilage-Backus 
                 7.4 
               
               
                   
                 104694 (BA) OA Bone-Backus 
                 56.3 
               
               
                   
                 104695 (BA) Adj “Normal” Bone-Backus 
                 31.6 
               
               
                   
                 104696 (BA) OA Synovium-Backus 
                 0.0 
               
               
                   
                 104700 (SS) OA Bone-Backus 
                 63.7 
               
               
                   
                 104701 (SS) Adj “Normal” Bone-Backus 
                 63.3 
               
               
                   
                 104702 (SS) OA Synovium-Backus 
                 6.1 
               
               
                   
                 117093 OA Cartilage Rep7 
                 16.3 
               
               
                   
                 112672 OA Bone5 
                 13.2 
               
               
                   
                 112673 OA Synovium5 
                 5.4 
               
               
                   
                 112674 OA Synovial Fluid cells5 
                 7.7 
               
               
                   
                 117100 OA Cartilage Rep14 
                 4.5 
               
               
                   
                 112756 OA Bone9 
                 17.1 
               
               
                   
                 112757 OA Synovium9 
                 21.8 
               
               
                   
                 112758 OA Synovial Fluid Cells9 
                 13.3 
               
               
                   
                 117125 RA Cartilage Rep2 
                 28.1 
               
               
                   
                 113492 Bone2 RA 
                 34.2 
               
               
                   
                 113493 Synovium2 RA 
                 8.9 
               
               
                   
                 113494 Syn Fluid Cells RA 
                 25.7 
               
               
                   
                 113499 Cartilage4 RA 
                 45.1 
               
               
                   
                 113500 Bone4 RA 
                 47.3 
               
               
                   
                 113501 Synovium4 RA 
                 42.6 
               
               
                   
                 113502 Syn Fluid Cells4 RA 
                 25.5 
               
               
                   
                 113495 Cartilage3 RA 
                 33.7 
               
               
                   
                 113496 Bone3 RA 
                 38.7 
               
               
                   
                 113497 Synovium3 RA 
                 18.2 
               
               
                   
                 113498 Syn Fluid Cells3 RA 
                 30.8 
               
               
                   
                 117106 Normal Cartilage Rep20 
                 0.0 
               
               
                   
                 113663 Bone3 Normal 
                 2.8 
               
               
                   
                 113664 Synovium3 Normal 
                 0.0 
               
               
                   
                 113665 Syn Fluid Cells3 Normal 
                 2.9 
               
               
                   
                 117107 Normal Cartilage Rep22 
                 10.5 
               
               
                   
                 113667 Bone4 Normal 
                 17.2 
               
               
                   
                 113668 Synovium4 Normal 
                 17.0 
               
               
                   
                 113669 Syn Fluid Cells4 Normal 
                 36.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3242, Run 253058919    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AWD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 0.0 
               
               
                   
                 Pancreas 
                 1.0 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
               
               
                   
                 Adrenal gland 
                 0.3 
               
               
                   
                 Thyroid 
                 0.0 
               
               
                   
                 Salivary gland 
                 0.6 
               
               
                   
                 Pituitary gland 
                 4.8 
               
               
                   
                 Brain (fetal) 
                 11.8 
               
               
                   
                 Brain (whole) 
                 40.6 
               
               
                   
                 Brain (amygdala) 
                 31.6 
               
               
                   
                 Brain (cerebellum) 
                 3.0 
               
               
                   
                 Brain (hippocampus) 
                 76.3 
               
               
                   
                 Brain (substantia nigra) 
                 2.1 
               
               
                   
                 Brain (thalamus) 
                 6.3 
               
               
                   
                 Cerebral Cortex 
                 27.7 
               
               
                   
                 Spinal cord 
                 7.7 
               
               
                   
                 glio/astro U87-MG 
                 0.6 
               
               
                   
                 glio/astro U-118-MG 
                 0.5 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 7.5 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 8.4 
               
               
                   
                 glioma SNB-19 
                 3.0 
               
               
                   
                 glioma U251 
                 66.4 
               
               
                   
                 glioma SF-295 
                 0.6 
               
               
                   
                 Heart (fetal) 
                 3.7 
               
               
                   
                 Heart 
                 1.7 
               
               
                   
                 Skeletal muscle (fetal) 
                 6.9 
               
               
                   
                 Skeletal muscle 
                 1.9 
               
               
                   
                 Bone marrow 
                 0.0 
               
               
                   
                 Thymus 
                 0.4 
               
               
                   
                 Spleen 
                 0.0 
               
               
                   
                 Lymph node 
                 0.0 
               
               
                   
                 Colorectal 
                 3.5 
               
               
                   
                 Stomach 
                 2.5 
               
               
                   
                 Small intestine 
                 7.2 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 0.0 
               
               
                   
                 Colon ca. HCC-2998 
                 2.1 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.0 
               
               
                   
                 Bladder 
                 0.0 
               
               
                   
                 Trachea 
                 9.0 
               
               
                   
                 Kidney 
                 1.5 
               
               
                   
                 Kidney (fetal) 
                 2.7 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. RXF 393 
                 0.4 
               
               
                   
                 Renal ca. ACHN 
                 100.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 1.1 
               
               
                   
                 Liver 
                 1.0 
               
               
                   
                 Liver (fetal) 
                 0.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
               
               
                   
                 Lung 
                 4.8 
               
               
                   
                 Lung (fetal) 
                 2.2 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 3.7 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 16.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 46.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 8.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 13.6 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 18.8 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
               
               
                   
                 Mammary gland 
                 1.4 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 1.4 
               
               
                   
                 Breast ca. BT-549 
                 1.6 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Ovary 
                 1.5 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 1.4 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 24.8 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.6 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 5.4 
               
               
                   
                 Uterus 
                 15.5 
               
               
                   
                 Placenta 
                 1.1 
               
               
                   
                 Prostate 
                 1.4 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 0.4 
               
               
                   
                 Testis 
                 2.3 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
               
               
                   
                 Melanoma M14 
                 1.6 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 58.6 
               
               
                   
                 Adipose 
                 1.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3242, Run 165524415    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AWE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2.2 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 4.4 
               
               
                   
                 Colon cancer (OD06064) 
                 1.8 
               
               
                   
                 Colon Margin (OD06064) 
                 8.9 
               
               
                   
                 Colon cancer (OD06159) 
                 2.0 
               
               
                   
                 Colon Margin (OD06159) 
                 7.1 
               
               
                   
                 Colon cancer (OD06297-04) 
                 2.4 
               
               
                   
                 Colon Margin (OD06297-05) 
                 2.2 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 0.9 
               
               
                   
                 CC Margin (ODO3921) 
                 3.8 
               
               
                   
                 Colon cancer metastasis (OD06104) 
                 0.7 
               
               
                   
                 Lung Margin (OD06104) 
                 0.0 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 1.7 
               
               
                   
                 Lung Margin (OD04451-02) 
                 10.1 
               
               
                   
                 Normal Prostate 
                 0.4 
               
               
                   
                 Prostate Cancer (OD04410) 
                 0.3 
               
               
                   
                 Prostate Margin (OD04410) 
                 0.0 
               
               
                   
                 Normal Ovary 
                 0.0 
               
               
                   
                 Ovarian cancer (OD06283-03) 
                 0.0 
               
               
                   
                 Ovarian Margin (OD06283-07) 
                 0.0 
               
               
                   
                 Ovarian Cancer 064008 
                 1.9 
               
               
                   
                 Ovarian cancer (OD06145) 
                 0.0 
               
               
                   
                 Ovarian Margin (OD06145) 
                 0.0 
               
               
                   
                 Ovarian cancer (OD06455-03) 
                 0.0 
               
               
                   
                 Ovarian Margin (OD06455-07) 
                 1.2 
               
               
                   
                 Normal Lung 
                 2.3 
               
               
                   
                 Invasive poor diff. lung adeno (ODO4945-01 
                 1.1 
               
               
                   
                 Lung Margin (ODO4945-03) 
                 1.6 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 0.7 
               
               
                   
                 Lung Margin (OD03126) 
                 1.2 
               
               
                   
                 Lung Cancer (OD05014A) 
                 1.2 
               
               
                   
                 Lung Margin (OD05014B) 
                 4.4 
               
               
                   
                 Lung cancer (OD06081) 
                 0.8 
               
               
                   
                 Lung Margin (OD06081) 
                 2.8 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 0.0 
               
               
                   
                 Lung Margin (OD04237-02) 
                 6.0 
               
               
                   
                 Ocular Melanoma Metastasis 
                 100.0 
               
               
                   
                 Ocular Melanoma Margin (Liver) 
                 0.7 
               
               
                   
                 Melanoma Metastasis 
                 1.2 
               
               
                   
                 Melanoma Margin (Lung) 
                 4.9 
               
               
                   
                 Normal Kidney 
                 0.0 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 1.3 
               
               
                   
                 Kidney Margin (OD04338) 
                 0.4 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 0.6 
               
               
                   
                 Kidney Margin (OD04339) 
                 1.6 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04340) 
                 1.1 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04348) 
                 1.0 
               
               
                   
                 Kidney malignant cancer (OD06204B) 
                 0.4 
               
               
                   
                 Kidney normal adjacent tissue (OD06204E) 
                 1.8 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 2.3 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 0.9 
               
               
                   
                 Kidney Cancer 8120613 
                 0.0 
               
               
                   
                 Kidney Margin 8120614 
                 0.4 
               
               
                   
                 Kidney Cancer 9010320 
                 1.4 
               
               
                   
                 Kidney Margin 9010321 
                 1.3 
               
               
                   
                 Kidney Cancer 8120607 
                 0.8 
               
               
                   
                 Kidney Margin 8120608 
                 0.2 
               
               
                   
                 Normal Uterus 
                 5.3 
               
               
                   
                 Uterine Cancer 064011 
                 0.5 
               
               
                   
                 Normal Thyroid 
                 0.0 
               
               
                   
                 Thyroid Cancer 064010 
                 0.7 
               
               
                   
                 Thyroid Cancer A302152 
                 0.9 
               
               
                   
                 Thyroid Margin A302153 
                 0.0 
               
               
                   
                 Normal Breast 
                 0.6 
               
               
                   
                 Breast Cancer (OD04566) 
                 0.0 
               
               
                   
                 Breast Cancer 1024 
                 2.1 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 0.0 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 0.0 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 0.4 
               
               
                   
                 Breast Cancer 064006 
                 0.7 
               
               
                   
                 Breast Cancer 9100266 
                 0.7 
               
               
                   
                 Breast Margin 9100265 
                 0.2 
               
               
                   
                 Breast Cancer A209073 
                 0.0 
               
               
                   
                 Breast Margin A2090734 
                 0.0 
               
               
                   
                 Breast cancer (OD06083) 
                 0.4 
               
               
                   
                 Breast cancer node metastasis (OD06083) 
                 0.9 
               
               
                   
                 Normal Liver 
                 1.3 
               
               
                   
                 Liver Cancer 1026 
                 0.3 
               
               
                   
                 Liver Cancer 1025 
                 0.0 
               
               
                   
                 Liver Cancer 6004-T 
                 0.0 
               
               
                   
                 Liver Tissue 6004-N 
                 0.0 
               
               
                   
                 Liver Cancer 6005-T 
                 2.7 
               
               
                   
                 Liver Tissue 6005-N 
                 3.3 
               
               
                   
                 Liver Cancer 064003 
                 7.1 
               
               
                   
                 Normal Bladder 
                 0.0 
               
               
                   
                 Bladder Cancer 1023 
                 0.0 
               
               
                   
                 Bladder Cancer A302173 
                 0.3 
               
               
                   
                 Normal Stomach 
                 5.8 
               
               
                   
                 Gastric Cancer 9060397 
                 0.0 
               
               
                   
                 Stomach Margin 9060396 
                 2.6 
               
               
                   
                 Gastric Cancer 9060395 
                 2.2 
               
               
                   
                 Stomach Margin 9060394 
                 3.4 
               
               
                   
                 Gastric Cancer 064005 
                 0.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3242, Run 174443348    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AWF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 0.0 
                 0.0 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 1.3 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.7 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.0 
                 0.0 
               
               
                   
                 LAK cells IL-2 
                 0.0 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.8 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.8 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 1.5 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.0 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 0.0 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 1.7 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 0.4 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 2.0 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
                 0.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + 
                 0.0 
                 0.0 
               
               
                   
                 IL-1beta 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + 
                 0.0 
                 0.0 
               
               
                   
                 IL-1beta 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
                 0.0 
               
               
                   
                 Small airway epithelium none 
                 0.0 
                 0.0 
               
               
                   
                 Small airway epithelium TNFalpha + 
                 6.5 
                 11.7 
               
               
                   
                 IL-1beta 
               
               
                   
                 Coronery artery SMC rest 
                 0.7 
                 0.0 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                   
                 Astrocytes rest 
                 13.9 
                 16.8 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 3.6 
                 5.3 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.9 
                 1.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 100.0 
                 100.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + 
                 0.0 
                 0.0 
               
               
                   
                 IL-1beta 
               
               
                   
                 Liver cirrhosis 
                 1.9 
                 3.8 
               
               
                   
                 Lupus kidney 
                 1.3 
                 1.4 
               
               
                   
                 NCI-H292 none 
                 42.9 
                 48.0 
               
               
                   
                 NCI-H292 IL-4 
                 14.7 
                 14.8 
               
               
                   
                 NCI-H292 IL-9 
                 40.6 
                 36.6 
               
               
                   
                 NCI-H292 IL-13 
                 12.2 
                 7.4 
               
               
                   
                 NCI-H292 IFN gamma 
                 16.8 
                 10.9 
               
               
                   
                 HPAEC none 
                 0.0 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 0.0 
                 1.7 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                   
                 Lung fibroblast IL-4 
                 1.7 
                 0.0 
               
               
                   
                 Lung fibroblast IL-9 
                 0.0 
                 0.0 
               
               
                   
                 Lung fibroblast IL-13 
                 0.7 
                 0.0 
               
               
                   
                 Lung fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 0.0 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.9 
                 0.0 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 0.0 
                 0.0 
               
               
                   
                 IBD Colitis 2 
                 0.8 
                 2.6 
               
               
                   
                 IBD Crohn&#39;s 
                 0.0 
                 2.0 
               
               
                   
                 Colon 
                 28.1 
                 23.2 
               
               
                   
                 Lung 
                 34.9 
                 51.4 
               
               
                   
                 Thymus 
                 35.1 
                 28.3 
               
               
                   
                 Kidney 
                 8.2 
                 7.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1096, Run 160353275    
               
               
                   
                   Column B - Rel. Exp. (%) Ag3242, Run 164390548    
               
            
           
         
       
     
      AI_comprehensive panel_v1.0 Summary: Ag3242 Expression of this gene was ubiquitous in this panel, with high expression in samples derived from patients suffering from ulcerative colitis, Crohns disease and psoriasis (CTs=33). Significant expression was also seen in samples derived from synovium, cartilage and bone of rheumatoid arthritis. Antibody or small molecule therapies designed with the protein encoded for by this gene are useful in the treatment of inflammatory bowel diseases and rheumatoid arthritis.  
      Panel 1.3D Summary: Ag3242 Highest expression of the CG57448-01 gene was seen in a renal cancer cell line (CT=31.1). Significant expression was also seen in cell lines derived from ovarian cancer, lung cancer, brain cancer and melanoma. Expression of this gene is useful as a marker to differentiate between these samples and other samples on this panel and as a diagnostic marker for the presence of these cancers. This gene encodes a protein that is homologous to cadherin, a cell-adhesion molecule.  
      Therapeutic modulation of the expression or function of this gene or gene prduct is effective in the treatment of lung, renal and melanoma cancers.  
      Expression of the this gene was also high in many regions of the brain, including the amygdala, thalamus, cerebellum, and cerebral cortex, with highest expression in the hippocampus. Expression was also detected in the spinal cord. Cadherins can act as axon guidance and cell adhesion proteins, specifically during development and in the response to injury (Ranscht B. (2000) Int. J. Dev. Neurosci. 18: 643-651.). Manipulation of levels of this protein are of use in inducing a compensatory synaptogenic response to neuronal death in Alzheimer&#39;s disease, Parkinson&#39;s disease, Huntington&#39;s disease, spinocerebellar ataxia, progressive supranuclear palsy, ALS, head trauma, stroke, or any other disease/condition associated with neuronal loss.  
      Among tissues with metabolic function, this gene was moderately expressed in pituitary gland, adrenal gland, thyroid, pancreas, skeletal muscle, and liver, reflecting the widespread role of cadherins in cell-cell adhesion. This expression shows that this gene product plays a role in normal metabolic and neuroendocrine function and that dysregulated expression of this gene contributes to metabolic diseases (such as obesity and diabetes) or neuroendocrine disorders.  
      Panel 2.2 Summary: Ag3242 Highest expression of this gene was seen inma sample derived from an ocular melanoma metastasis (CT=29). Thus, expression of this gene is useful as a marker to differentiate between this sample and other samples on this panel.  
      Panel 4D Summary: Ag1096/Ag3242 Highest expression of this gene was detected in the basophil cell line (KU-812) treated with PMA/ionomycin (CTs=30-32). Significant expression was also seen in a cluster of treated and untreated samples derived from the muco-epidermoid cell line NCI-H292. Thus, this gene, which encodes a cadherin homolog, was expressed in both a cell line that is often used as a model of airway epithelium (NCI-H292) and a cell line that is a reasonable model for the inflammatory cells that contribute to various inflammatory lung diseases. Therapeutic modulation of this gene or gene prodcut may is useful to reduce or eliminate the symptoms of patients suffering from pathological and inflammatory lung disorders, including chronic obstructive pulmonary disease, asthma, allergy and emphysema.  
      Low but significant levels of expression were also seen in the samples derived from normal colon, kidney, lung and thymus. Therapeutic modulation of the expression or function of this gene or gene product is important for maintaining or restoring normal function to this organs during inflammation.  
      AX. CG5740905 and CG57409-07: Protein Containing MAM and Ig Domains  
      Expression of gene CG57409-05 and full length physical clone CG57409-07 was assessed using the primer-probe sets Ag5267 and Ag6188, described in Tables AXA and AXB. Results of the RTQ-PCR runs are shown in Tables AXC, AXD and AXE.  
               TABLE AXA                          Probe Name Ag5267                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-gcggtcccggaaca-3′   14   1166   1528                   Probe   TET-5′-cacgcctggtctctcagtggca-3′-TAMRA   22   1197   1529               Reverse   5′-gcctgctgccacacatt-3′   17   1227   1530                  
 
     
       
         
           
               
             
               
                 TABLE AXB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag6188 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-ataaagtggtggtgatgcc-3′ 
                 19 
                 1381 
                 1531 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-agtggagccccctgccagtc-3′-TAMRA 
                 20 
                 1404 
                 1532 
               
               
                   
               
               
                 Reverse 
                 5′-gaggaagatggccatg-3′ 
                 16 
                 1445 
                 1533 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AXC 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.5 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 1.5 
               
               
                   
                 Melanoma* Hs688(A).T 
                 4.4 
               
               
                   
                 Melanoma* Hs688(B).T 
                 7.7 
               
               
                   
                 Melanoma* M14 
                 0.2 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.3 
               
               
                   
                 Melanoma* SK-MEL-5 
                 9.2 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.0 
               
               
                   
                 Testis Pool 
                 0.7 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate Pool 
                 2.0 
               
               
                   
                 Placenta 
                 0.0 
               
               
                   
                 Uterus Pool 
                 2.1 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.4 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 7.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 1.8 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 2.2 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.5 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.7 
               
               
                   
                 Ovary 
                 4.3 
               
               
                   
                 Breast ca. MCF-7 
                 0.0 
               
               
                   
                 Breast ca. MDA-MB-231 
                 3.5 
               
               
                   
                 Breast ca. BT 549 
                 7.5 
               
               
                   
                 Breast ca. T47D 
                 2.5 
               
               
                   
                 Breast ca. MDA-N 
                 2.6 
               
               
                   
                 Breast Pool 
                 5.7 
               
               
                   
                 Trachea 
                 0.5 
               
               
                   
                 Lung 
                 2.5 
               
               
                   
                 Fetal Lung 
                 4.3 
               
               
                   
                 Lungca. NCI-N417 
                 0.6 
               
               
                   
                 Lung ca. LX-1 
                 3.6 
               
               
                   
                 Lung ca. NCI-H146 
                 0.0 
               
               
                   
                 Lung ca. SHP-77 
                 0.3 
               
               
                   
                 Lung ca. A549 
                 2.6 
               
               
                   
                 Lung ca. NCI-H526 
                 0.2 
               
               
                   
                 Lung ca. NCI-H23 
                 0.1 
               
               
                   
                 Lung ca. NCI-H460 
                 0.2 
               
               
                   
                 Lung ca. HOP-62 
                 1.3 
               
               
                   
                 Lung ca. NCI-H522 
                 19.3 
               
               
                   
                 Liver 
                 0.1 
               
               
                   
                 Fetal Liver 
                 0.3 
               
               
                   
                 Liver ca. HepG2 
                 0.0 
               
               
                   
                 Kidney Pool 
                 13.3 
               
               
                   
                 Fetal Kidney 
                 1.2 
               
               
                   
                 Renal ca. 786-0 
                 0.3 
               
               
                   
                 Renal ca. A498 
                 5.2 
               
               
                   
                 Renal ca. ACHN 
                 6.1 
               
               
                   
                 Renal ca. UO-31 
                 2.5 
               
               
                   
                 Renal ca. TK-10 
                 3.4 
               
               
                   
                 Bladder 
                 1.0 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.0 
               
               
                   
                 Gastric ca. KATO III 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 3.5 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.3 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 2.6 
               
               
                   
                 Colon ca. CaCo-2 
                 0.1 
               
               
                   
                 Colon cancer tissue 
                 0.9 
               
               
                   
                 Colon ca. SW1116 
                 0.2 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 7.3 
               
               
                   
                 Small Intestine Pool 
                 8.7 
               
               
                   
                 Stomach Pool 
                 2.5 
               
               
                   
                 Bone Marrow Pool 
                 3.6 
               
               
                   
                 Fetal Heart 
                 1.5 
               
               
                   
                 Heart Pool 
                 3.5 
               
               
                   
                 Lymph Node Pool 
                 6.2 
               
               
                   
                 Fetal Skeletal Muscle 
                 4.9 
               
               
                   
                 Skeletal Muscle Pool 
                 1.0 
               
               
                   
                 Spleen Pool 
                 2.1 
               
               
                   
                 Thymus Pool 
                 2.9 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 1.3 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 7.2 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.3 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.6 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 27.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.5 
               
               
                   
                 CNS cancer (glio) SF-295 
                 4.2 
               
               
                   
                 Brain (Amygdala) Pool 
                 2.3 
               
               
                   
                 Brain (cerebellum) 
                 100.0 
               
               
                   
                 Brain (fetal) 
                 34.4 
               
               
                   
                 Brain (Hippocampus) Pool 
                 3.0 
               
               
                   
                 Cerebral Cortex Pool 
                 3.5 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 3.2 
               
               
                   
                 Brain (Thalamus) Pool 
                 2.7 
               
               
                   
                 Brain (whole) 
                 5.1 
               
               
                   
                 Spinal Cord Pool 
                 5.4 
               
               
                   
                 Adrenal Gland 
                 4.0 
               
               
                   
                 Pituitary gland Pool 
                 2.0 
               
               
                   
                 Salivary Gland 
                 0.2 
               
               
                   
                 Thyroid (female) 
                 0.3 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.0 
               
               
                   
                 Pancreas Pool 
                 2.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag6188, Run 257761488    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AXD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 4.3 
               
               
                   
                 Secondary Tr1 act 
                 3.4 
               
               
                   
                 Secondary Th1 rest 
                 0.6 
               
               
                   
                 Secondary Th2 rest 
                 2.1 
               
               
                   
                 Secondary Tr1 rest 
                 0.8 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.6 
               
               
                   
                 Primary Tr1 act 
                 0.8 
               
               
                   
                 Primary Th1 rest 
                 0.2 
               
               
                   
                 Primary Th2 rest 
                 0.3 
               
               
                   
                 Primary Tr1 rest 
                 0.2 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 1.6 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 3.4 
               
               
                   
                 CD8 lymphocyte act 
                 0.4 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.1 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.2 
               
               
                   
                 CD4 lymphocyte none 
                 0.9 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 1.8 
               
               
                   
                 LAK cells rest 
                 6.2 
               
               
                   
                 LAK cells IL-2 
                 3.3 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 1.2 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.7 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.6 
               
               
                   
                 LAK cells PMA/ionomycin 
                 41.8 
               
               
                   
                 NK Cells IL-2 rest 
                 9.0 
               
               
                   
                 Two Way MLR 3 day 
                 2.9 
               
               
                   
                 Two Way MLR 5 day 
                 3.5 
               
               
                   
                 Two Way MLR 7 day 
                 2.7 
               
               
                   
                 PBMC rest 
                 0.3 
               
               
                   
                 PBMC PWM 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 1.2 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.7 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 7.6 
               
               
                   
                 EOL-1 dbcAMP 
                 7.7 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 100.0 
               
               
                   
                 Dendritic cells none 
                 0.5 
               
               
                   
                 Dendritic cells LPS 
                 0.4 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.4 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 3.0 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.7 
               
               
                   
                 HUVEC none 
                 0.7 
               
               
                   
                 HUVEC starved 
                 1.2 
               
               
                   
                 HUVEC IL-1beta 
                 1.4 
               
               
                   
                 HUVEC IFN gamma 
                 4.8 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 3.8 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.4 
               
               
                   
                 HUVEC IL-11 
                 0.4 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.4 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.2 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.7 
               
               
                   
                 Small airway epithelium none 
                 0.2 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 1.6 
               
               
                   
                 Coronery artery SMC rest 
                 0.9 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 1.9 
               
               
                   
                 Astrocytes rest 
                 8.8 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 11.0 
               
               
                   
                 KU-812 (Basophil) rest 
                 1.4 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 9.3 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 4.8 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 1.2 
               
               
                   
                 Liver cirrhosis 
                 2.0 
               
               
                   
                 NCI-H292 none 
                 0.4 
               
               
                   
                 NCI-H292 IL-4 
                 1.8 
               
               
                   
                 NCI-H292 IL-9 
                 1.4 
               
               
                   
                 NCI-H292 IL-13 
                 2.8 
               
               
                   
                 NCI-H292 IFN gamma 
                 5.6 
               
               
                   
                 HPAEC none 
                 0.2 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 4.9 
               
               
                   
                 Lung fibroblast none 
                 46.7 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 9.7 
               
               
                   
                 Lung fibroblast IL-4 
                 23.5 
               
               
                   
                 Lung fibroblast IL-9 
                 32.5 
               
               
                   
                 Lung fibroblast IL-13 
                 18.6 
               
               
                   
                 Lung fibroblast IFN gamma 
                 73.7 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 1.8 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.3 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 2.0 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 11.7 
               
               
                   
                 Dermal fibroblast IL-4 
                 4.0 
               
               
                   
                 Dermal Fibroblasts rest 
                 10.1 
               
               
                   
                 Neutrophils TNFa + LPS 
                 0.0 
               
               
                   
                 Neutrophils rest 
                 0.7 
               
               
                   
                 Colon 
                 0.6 
               
               
                   
                 Lung 
                 0.7 
               
               
                   
                 Thymus 
                 1.1 
               
               
                   
                 Kidney 
                 2.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag5267, Run 230510063    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AXE 
               
             
            
               
                   
               
               
                   
               
               
                 general oncology screening panel_v_2.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Colon cancer 1 
                 6.4 
               
               
                   
                 Colon cancer NAT 1 
                 0.0 
               
               
                   
                 Colon cancer 2 
                 2.7 
               
               
                   
                 Colon cancer NAT 2 
                 3.9 
               
               
                   
                 Colon cancer 3 
                 7.0 
               
               
                   
                 Colon cancer NAT 3 
                 11.5 
               
               
                   
                 Colon malignant cancer 4 
                 5.5 
               
               
                   
                 Colon normal adjacent tissue 4 
                 3.7 
               
               
                   
                 Lung cancer 1 
                 7.7 
               
               
                   
                 Lung NAT 1 
                 0.5 
               
               
                   
                 Lung cancer 2 
                 12.3 
               
               
                   
                 Lung NAT 2 
                 3.2 
               
               
                   
                 Squamous cell carcinoma 3 
                 48.6 
               
               
                   
                 Lung NAT 3 
                 4.5 
               
               
                   
                 metastatic melanoma 1 
                 52.1 
               
               
                   
                 Melanoma 2 
                 23.8 
               
               
                   
                 Melanoma 3 
                 3.4 
               
               
                   
                 metastatic melanoma 4 
                 97.9 
               
               
                   
                 metastatic melanoma 5 
                 100.0 
               
               
                   
                 Bladder cancer 1 
                 4.5 
               
               
                   
                 Bladder cancer NAT 1 
                 0.0 
               
               
                   
                 Bladder cancer 2 
                 19.5 
               
               
                   
                 Bladder cancer NAT 2 
                 1.4 
               
               
                   
                 Bladder cancer NAT 3 
                 0.0 
               
               
                   
                 Bladder cancer NAT 4 
                 20.9 
               
               
                   
                 Prostate adenocarcinoma 1 
                 69.3 
               
               
                   
                 Prostate adenocarcinoma 2 
                 6.5 
               
               
                   
                 Prostate adenocarcinoma 3 
                 17.7 
               
               
                   
                 Prostate adenocarcinoma 4 
                 11.7 
               
               
                   
                 Prostate cancer NAT 5 
                 5.0 
               
               
                   
                 Prostate adenocarcinoma 6 
                 13.4 
               
               
                   
                 Prostate adenocarcinoma 7 
                 10.3 
               
               
                   
                 Prostate adenocarcinoma 8 
                 11.3 
               
               
                   
                 Prostate adenocarcinoma 9 
                 93.3 
               
               
                   
                 Prostate cancer NAT 10 
                 1.4 
               
               
                   
                 Kidney cancer 1 
                 14.8 
               
               
                   
                 KidneyNAT 1 
                 2.9 
               
               
                   
                 Kidney cancer 2 
                 16.4 
               
               
                   
                 Kidney NAT 2 
                 12.2 
               
               
                   
                 Kidney cancer 3 
                 18.4 
               
               
                   
                 Kidney NAT 3 
                 5.3 
               
               
                   
                 Kidney cancer 4 
                 2.8 
               
               
                   
                 Kidney NAT 4 
                 2.1 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag6188, Run 264979750    
               
            
           
         
       
     
      General_screening_panel_v1.5 Summary: Ag6188 Significant expression of this gene was seen in the brain. Expression of this gene is useful as a marker to differentiate between brain derived samples and other samples on this panel.  
      Among tissues with metabolic function, this gene was expressed at moderate to low levels in pituitary, adipose, adrenal gland, pancreas, thyroid, and adult and fetal skeletal muscle, heart, and liver. This widespread expression among these tissues shows that this gene product plays a role in normal neuroendocrine and metabolic function and that disregulated expression of this gene contributes to neuroendocrine disorders or metabolic diseases, such as obesity and diabetes.  
      Panel 4.1D Summary: Ag5267 This transcript was expressed in LAK cells and treatment of the LAK cells with PMA and ionomycin upregulated the expression of this transcript. This transcript was also induced in activated EOL cells and in fibroblasts. This gene encodes a putative NCAM, a type of cell surface protein often involved in cellular interaction, adhesion and signaling. Therapeutics designed with the protein encoded for this transcript are important in the treatment of diseases such as asthma, emphysema, psoriasis and arthritis.  
      general oncology screening panel_V — 2.4 Summary: Ag6188 Highest expression of this gene was seen in two melanoma samples (CTs=31). Prominent expression was seen in a squamous cell carcinoma sample and two prostate adenocarcinoma samples. Targeting this gene or its protein product is useful in the treatment of these cancers.  
      AY. CG57448-01: Protocadherin 10  
      Expression of gene CG57448-01 was assessed using the primer-probe sets Ag1096, and Ag3242, described in Tables AYA and AYB. Results of the RTQ-PCR runs are shown in Tables AYC, AYD, AYE, AYF, and AYG.  
               TABLE AYA                          Probe Name Ag1096                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-actttggaagaggcattgct-3′   20   2455   1534                   Probe   TET-5′-cagacagattatgggctccatcgctt-3′-   26   2476   1535           TAMRA               Reverse   5′-ctcgggataaccatgatcact-3′   21   2515   1536                  
 
     
       
         
           
               
             
               
                 TABLE AYB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag3242 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Forward 
                 5′-gggaccaatgctcaaattactt-3′ 
                 22 
                 1090 
                 1537 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-tcagaaagttccacaagcatctaagga-3′- 
                 27 
                 1122 
                 1538 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-atgactccagtgttttcatcca-3′ 
                 22 
                 1160 
                 1539 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AYC 
               
             
            
               
                   
               
               
                   
               
               
                 AI_comprehensive panel_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 110967 COPD-F 
                 28.9 
               
               
                   
                 110980 COPD-F 
                 6.7 
               
               
                   
                 110968 COPD-M 
                 19.9 
               
               
                   
                 110977 COPD-M 
                 8.4 
               
               
                   
                 110989 Emphysema-F 
                 49.3 
               
               
                   
                 110992 Emphysema-F 
                 22.8 
               
               
                   
                 110993 Emphysema-F 
                 31.0 
               
               
                   
                 110994 Emphysema-F 
                 12.7 
               
               
                   
                 110995 Emphysema-F 
                 25.5 
               
               
                   
                 110996 Emphysema-F 
                 15.8 
               
               
                   
                 110997 Asthma-M 
                 7.5 
               
               
                   
                 111001 Asthma-F 
                 30.4 
               
               
                   
                 111002 Asthma-F 
                 45.4 
               
               
                   
                 111003 Atopic Asthma-F 
                 45.1 
               
               
                   
                 111004 Atopic Asthma-F 
                 22.4 
               
               
                   
                 111005 Atopic Asthma-F 
                 25.3 
               
               
                   
                 111006 Atopic Asthma-F 
                 13.9 
               
               
                   
                 111417 Allergy-M 
                 15.1 
               
               
                   
                 112347 Allergy-M 
                 5.0 
               
               
                   
                 112349 Normal Lung-F 
                 1.9 
               
               
                   
                 112357 Normal Lung-F 
                 5.1 
               
               
                   
                 112354 Normal Lung-M 
                 11.6 
               
               
                   
                 112374 Crohns-F 
                 32.5 
               
               
                   
                 112389 Match Control Crohns-F 
                 14.4 
               
               
                   
                 112375 Crohns-F 
                 36.1 
               
               
                   
                 112732 Match Control Crohns-F 
                 0.0 
               
               
                   
                 112725 Crohns-M 
                 45.4 
               
               
                   
                 112387 Match Control Crohns-M 
                 18.3 
               
               
                   
                 112378 Crohns-M 
                 3.8 
               
               
                   
                 112390 Match Control Crohns-M 
                 22.4 
               
               
                   
                 112726 Crohns-M 
                 45.7 
               
               
                   
                 112731 Match Control Crohns-M 
                 12.6 
               
               
                   
                 112380 Ulcer Col-F 
                 28.3 
               
               
                   
                 112734 Match Control Ulcer Col-F 
                 0.8 
               
               
                   
                 112384 Ulcer Col-F 
                 100.0 
               
               
                   
                 112737 Match Control Ulcer Col-F 
                 28.1 
               
               
                   
                 112386 Ulcer Col-F 
                 25.5 
               
               
                   
                 112738 Match Control Ulcer Col-F 
                 2.1 
               
               
                   
                 112381 Ulcer Col-M 
                 2.3 
               
               
                   
                 112735 Match Control Ulcer Col-M 
                 53.6 
               
               
                   
                 112382 Ulcer Col-M 
                 15.3 
               
               
                   
                 112394 Match Control Ulcer Col-M 
                 10.2 
               
               
                   
                 112383 Ulcer Col-M 
                 45.4 
               
               
                   
                 112736 Match Control Ulcer Col-M 
                 4.0 
               
               
                   
                 112423 Psoriasis-F 
                 90.1 
               
               
                   
                 112427 Match Control Psoriasis-F 
                 55.9 
               
               
                   
                 112418 Psoriasis-M 
                 25.7 
               
               
                   
                 112723 Match Control Psoriasis-M 
                 0.0 
               
               
                   
                 112419 Psoriasis-M 
                 66.0 
               
               
                   
                 112424 Match Control Psoriasis-M 
                 42.0 
               
               
                   
                 112420 Psoriasis-M 
                 44.4 
               
               
                   
                 112425 Match Control Psoriasis-M 
                 24.3 
               
               
                   
                 104689 (MF) OA Bone-Backus 
                 81.2 
               
               
                   
                 104690 (MF) Adj “Normal” Bone-Backus 
                 16.6 
               
               
                   
                 104691 (MF) OA Synovium-Backus 
                 1.5 
               
               
                   
                 104692 (BA) OA Cartilage-Backus 
                 7.4 
               
               
                   
                 104694 (BA) OA Bone-Backus 
                 56.3 
               
               
                   
                 104695 (BA) Adj “Normal” Bone-Backus 
                 31.6 
               
               
                   
                 104696 (BA) OA Synovium-Backus 
                 0.0 
               
               
                   
                 104700 (SS) OA Bone-Backus 
                 63.7 
               
               
                   
                 104701 (SS) Adj “Normal” Bone-Backus 
                 63.3 
               
               
                   
                 104702 (SS) OA Synovium-Backus 
                 6.1 
               
               
                   
                 117093 OA Cartilage Rep7 
                 16.3 
               
               
                   
                 112672 OA Bone5 
                 13.2 
               
               
                   
                 112673 OA Synovium5 
                 5.4 
               
               
                   
                 112674 OA Synovial Fluid cells5 
                 7.7 
               
               
                   
                 117100 OA Cartilage Rep14 
                 4.5 
               
               
                   
                 112756 OA Bone9 
                 17.1 
               
               
                   
                 112757 OA Synovium9 
                 21.8 
               
               
                   
                 112758 OA Synovial Fluid Cells9 
                 13.3 
               
               
                   
                 117125 RA Cartilage Rep2 
                 28.1 
               
               
                   
                 113492 Bone2 RA 
                 34.2 
               
               
                   
                 113493 Synovium2 RA 
                 8.9 
               
               
                   
                 113494 Syn Fluid Cells RA 
                 25.7 
               
               
                   
                 113499 Cartilage4 RA 
                 45.1 
               
               
                   
                 113500 Bone4 RA 
                 47.3 
               
               
                   
                 113501 Synovium4 RA 
                 42.6 
               
               
                   
                 113502 Syn Fluid Cells4 RA 
                 25.5 
               
               
                   
                 113495 Cartilage3 RA 
                 33.7 
               
               
                   
                 113496 Bone3 RA 
                 38.7 
               
               
                   
                 113497 Synovium3 RA 
                 18.2 
               
               
                   
                 113498 Syn Fluid Cells3 RA 
                 30.8 
               
               
                   
                 117106 Normal Cartilage Rep20 
                 0.0 
               
               
                   
                 113663 Bone3 Normal 
                 2.8 
               
               
                   
                 113664 Synovium3 Normal 
                 0.0 
               
               
                   
                 113665 Syn Fluid Cells3 Normal 
                 2.9 
               
               
                   
                 117107 Normal Cartilage Rep22 
                 10.5 
               
               
                   
                 113667 Bone4 Normal 
                 17.2 
               
               
                   
                 113668 Synovium4 Normal 
                 17.0 
               
               
                   
                 113669 Syn Fluid Cells4 Normal 
                 36.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3242, Run 253058919    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AYD 
               
             
            
               
                   
               
               
                   
               
               
                 CNS_neurodegeneration_v1.0 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 AD 1 Hippo 
                 74.2 
                 45.4 
               
               
                   
                 AD 2 Hippo 
                 18.8 
                 27.5 
               
               
                   
                 AD 3 Hippo 
                 32.3 
                 19.5 
               
               
                   
                 AD 4 Hippo 
                 6.8 
                 6.3 
               
               
                   
                 AD 5 Hippo 
                 39.2 
                 30.8 
               
               
                   
                 AD 6 Hippo 
                 100.0 
                 100.0 
               
               
                   
                 Control 2 Hippo 
                 89.5 
                 61.6 
               
               
                   
                 Control 4 Hippo 
                 13.6 
                 10.1 
               
               
                   
                 Control (Path) 3 Hippo 
                 17.6 
                 3.8 
               
               
                   
                 AD 1 Temporal Ctx 
                 8.2 
                 6.2 
               
               
                   
                 AD 2 Temporal Ctx 
                 19.8 
                 11.8 
               
               
                   
                 AD 3 Temporal Ctx 
                 9.9 
                 4.0 
               
               
                   
                 AD 4 Temporal Ctx 
                 12.1 
                 6.3 
               
               
                   
                 AD 5 Inf Temporal Ctx 
                 59.5 
                 47.3 
               
               
                   
                 AD 5 Sup Temporal Ctx 
                 72.7 
                 67.8 
               
               
                   
                 AD 6 Inf Temporal Ctx 
                 12.9 
                 12.9 
               
               
                   
                 AD 6 Sup Temporal Ctx 
                 14.6 
                 12.2 
               
               
                   
                 Control 1 Temporal Ctx 
                 7.5 
                 8.5 
               
               
                   
                 Control 2 Temporal Ctx 
                 34.4 
                 35.1 
               
               
                   
                 Control 3 Temporal Ctx 
                 13.9 
                 10.8 
               
               
                   
                 Control 3 Temporal Ctx 
                 5.2 
                 2.9 
               
               
                   
                 Control (Path) 1 Temporal Ctx 
                 38.7 
                 32.8 
               
               
                   
                 Control (Path) 2 Temporal Ctx 
                 25.7 
                 18.3 
               
               
                   
                 Control (Path) 3 Temporal Ctx 
                 4.1 
                 6.0 
               
               
                   
                 Control (Path) 4 Temporal Ctx 
                 18.4 
                 7.6 
               
               
                   
                 AD 1 Occipital Ctx 
                 14.8 
                 7.0 
               
               
                   
                 AD 2 Occipital Ctx (Missing) 
                 0.6 
                 1.9 
               
               
                   
                 AD 3 Occipital Ctx 
                 23.2 
                 11.5 
               
               
                   
                 AD 4 Occipital Ctx 
                 12.8 
                 8.4 
               
               
                   
                 AD 5 Occipital Ctx 
                 34.6 
                 23.3 
               
               
                   
                 AD 6 Occipital Ctx 
                 10.7 
                 2.1 
               
               
                   
                 Control 1 Occipital Ctx 
                 4.0 
                 1.6 
               
               
                   
                 Control 2 Occipital Ctx 
                 20.6 
                 23.5 
               
               
                   
                 Control 3 Occipital Ctx 
                 6.7 
                 7.7 
               
               
                   
                 Control 4 Occipital Ctx 
                 5.1 
                 2.8 
               
               
                   
                 Control (Path) 1 Occipital Ctx 
                 30.4 
                 26.4 
               
               
                   
                 Control (Path) 2 Occipital Ctx 
                 6.5 
                 1.9 
               
               
                   
                 Control (Path) 3 Occipital Ctx 
                 4.4 
                 2.6 
               
               
                   
                 Control (Path) 4 Occipital Ctx 
                 7.1 
                 3.2 
               
               
                   
                 Control 1 Parietal Ctx 
                 4.6 
                 4.8 
               
               
                   
                 Control 2 Parietal Ctx 
                 27.0 
                 24.3 
               
               
                   
                 Control 3 Parietal Ctx 
                 14.5 
                 14.0 
               
               
                   
                 Control (Path) 1 Parietal Ctx 
                 40.3 
                 40.3 
               
               
                   
                 Control (Path) 2 Parietal Ctx 
                 17.2 
                 7.8 
               
               
                   
                 Control (Path) 3 Parietal Ctx 
                 7.0 
                 2.7 
               
               
                   
                 Control (Path) 4 Parietal Ctx 
                 21.8 
                 20.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1096, Run 206231465    
               
               
                   
                   Column B - Rel. Exp. (%) Ag3242, Run 206533581    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AYE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 0.0 
               
               
                   
                 Pancreas 
                 1.0 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
               
               
                   
                 Adrenal gland 
                 0.3 
               
               
                   
                 Thyroid 
                 0.0 
               
               
                   
                 Salivary gland 
                 0.6 
               
               
                   
                 Pituitary gland 
                 4.8 
               
               
                   
                 Brain (fetal) 
                 11.8 
               
               
                   
                 Brain (whole) 
                 40.6 
               
               
                   
                 Brain (amygdala) 
                 31.6 
               
               
                   
                 Brain (cerebellum) 
                 3.0 
               
               
                   
                 Brain (hippocampus) 
                 76.3 
               
               
                   
                 Brain (substantia nigra) 
                 2.1 
               
               
                   
                 Brain (thalamus) 
                 6.3 
               
               
                   
                 Cerebral Cortex 
                 27.7 
               
               
                   
                 Spinal cord 
                 7.7 
               
               
                   
                 glio/astro U87-MG 
                 0.6 
               
               
                   
                 glio/astro U-118-MG 
                 0.5 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 7.5 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 8.4 
               
               
                   
                 glioma SNB-19 
                 3.0 
               
               
                   
                 glioma U251 
                 66.4 
               
               
                   
                 glioma SF-295 
                 0.6 
               
               
                   
                 Heart (fetal) 
                 3.7 
               
               
                   
                 Heart 
                 1.7 
               
               
                   
                 Skeletal muscle (fetal) 
                 6.9 
               
               
                   
                 Skeletal muscle 
                 1.9 
               
               
                   
                 Bone marrow 
                 0.0 
               
               
                   
                 Thymus 
                 0.4 
               
               
                   
                 Spleen 
                 0.0 
               
               
                   
                 Lymph node 
                 0.0 
               
               
                   
                 Colorectal 
                 3.5 
               
               
                   
                 Stomach 
                 2.5 
               
               
                   
                 Small intestine 
                 7.2 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 0.0 
               
               
                   
                 Colon ca. HCC-2998 
                 2.1 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.0 
               
               
                   
                 Bladder 
                 0.0 
               
               
                   
                 Trachea 
                 9.0 
               
               
                   
                 Kidney 
                 1.5 
               
               
                   
                 Kidney (fetal) 
                 2.7 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. RXF 393 
                 0.4 
               
               
                   
                 Renal ca. ACHN 
                 100.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 1.1 
               
               
                   
                 Liver 
                 1.0 
               
               
                   
                 Liver (fetal) 
                 0.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
               
               
                   
                 Lung 
                 4.8 
               
               
                   
                 Lung (fetal) 
                 2.2 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 3.7 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 16.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 46.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 8.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 13.6 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 18.8 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
               
               
                   
                 Mammary gland 
                 1.4 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 1.4 
               
               
                   
                 Breast ca. BT-549 
                 1.6 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
               
               
                   
                 Ovary 
                 1.5 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 1.4 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 24.8 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.6 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 5.4 
               
               
                   
                 Uterus 
                 15.5 
               
               
                   
                 Placenta 
                 1.1 
               
               
                   
                 Prostate 
                 1.4 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 0.4 
               
               
                   
                 Testis 
                 2.3 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
               
               
                   
                 Melanoma M14 
                 1.6 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 58.6 
               
               
                   
                 Adipose 
                 1.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3242, Run 165524415    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AYF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2.2 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 4.4 
               
               
                   
                 Colon cancer (OD06064) 
                 1.8 
               
               
                   
                 Colon Margin (OD06064) 
                 8.9 
               
               
                   
                 Colon cancer (OD06159) 
                 2.0 
               
               
                   
                 Colon Margin (OD06159) 
                 7.1 
               
               
                   
                 Colon cancer (OD06297-04) 
                 2.4 
               
               
                   
                 Colon Margin (OD06297-05) 
                 2.2 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 0.9 
               
               
                   
                 CC Margin (ODO3921) 
                 3.8 
               
               
                   
                 Colon cancer metastasis (OD06104) 
                 0.7 
               
               
                   
                 Lung Margin (OD06104) 
                 0.0 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 1.7 
               
               
                   
                 Lung Margin (OD04451-02) 
                 10.1 
               
               
                   
                 Normal Prostate 
                 0.4 
               
               
                   
                 Prostate Cancer (OD04410) 
                 0.3 
               
               
                   
                 Prostate Margin (OD04410) 
                 0.0 
               
               
                   
                 Normal Ovary 
                 0.0 
               
               
                   
                 Ovarian cancer (OD06283-03) 
                 0.0 
               
               
                   
                 Ovarian Margin (OD06283-07) 
                 0.0 
               
               
                   
                 Ovarian Cancer 064008 
                 1.9 
               
               
                   
                 Ovarian cancer (OD06145) 
                 0.0 
               
               
                   
                 Ovarian Margin (OD06145) 
                 0.0 
               
               
                   
                 Ovarian cancer (OD06455-03) 
                 0.0 
               
               
                   
                 Ovarian Margin (OD06455-07) 
                 1.2 
               
               
                   
                 Normal Lung 
                 2.3 
               
               
                   
                 Invasive poor diff. lung adeno (ODO4945-01 
                 1.1 
               
               
                   
                 Lung Margin (ODO4945-03) 
                 1.6 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 0.7 
               
               
                   
                 Lung Margin (OD03126) 
                 1.2 
               
               
                   
                 Lung Cancer (OD05014A) 
                 1.2 
               
               
                   
                 Lung Margin (OD05014B) 
                 4.4 
               
               
                   
                 Lung cancer (OD06081) 
                 0.8 
               
               
                   
                 Lung Margin (OD06081) 
                 2.8 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 0.0 
               
               
                   
                 Lung Margin (OD04237-02) 
                 6.0 
               
               
                   
                 Ocular Melanoma Metastasis 
                 100.0 
               
               
                   
                 Ocular Melanoma Margin (Liver) 
                 0.7 
               
               
                   
                 Melanoma Metastasis 
                 1.2 
               
               
                   
                 Melanoma Margin (Lung) 
                 4.9 
               
               
                   
                 Normal Kidney 
                 0.0 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 1.3 
               
               
                   
                 Kidney Margin (OD04338) 
                 0.4 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 0.6 
               
               
                   
                 Kidney Margin (OD04339) 
                 1.6 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04340) 
                 1.1 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04348) 
                 1.0 
               
               
                   
                 Kidney malignant cancer (OD06204B) 
                 0.4 
               
               
                   
                 Kidney normal adjacent tissue (OD06204E) 
                 1.8 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 2.3 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 0.9 
               
               
                   
                 Kidney Cancer 8120613 
                 0.0 
               
               
                   
                 Kidney Margin 8120614 
                 0.4 
               
               
                   
                 Kidney Cancer 9010320 
                 1.4 
               
               
                   
                 Kidney Margin 9010321 
                 1.3 
               
               
                   
                 Kidney Cancer 8120607 
                 0.8 
               
               
                   
                 Kidney Margin 8120608 
                 0.2 
               
               
                   
                 Normal Uterus 
                 5.3 
               
               
                   
                 Uterine Cancer 064011 
                 0.5 
               
               
                   
                 Normal Thyroid 
                 0.0 
               
               
                   
                 Thyroid Cancer 064010 
                 0.7 
               
               
                   
                 Thyroid Cancer A302152 
                 0.9 
               
               
                   
                 Thyroid Margin A302153 
                 0.0 
               
               
                   
                 Normal Breast 
                 0.6 
               
               
                   
                 Breast Cancer (OD04566) 
                 0.0 
               
               
                   
                 Breast Cancer 1024 
                 2.1 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 0.0 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 0.0 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 0.4 
               
               
                   
                 Breast Cancer 064006 
                 0.7 
               
               
                   
                 Breast Cancer 9100266 
                 0.7 
               
               
                   
                 Breast Margin 9100265 
                 0.2 
               
               
                   
                 Breast Cancer A209073 
                 0.0 
               
               
                   
                 Breast Margin A2090734 
                 0.0 
               
               
                   
                 Breast cancer (OD06083) 
                 0.4 
               
               
                   
                 Breast cancer node metastasis (OD06083) 
                 0.9 
               
               
                   
                 Normal Liver 
                 1.3 
               
               
                   
                 Liver Cancer 1026 
                 0.3 
               
               
                   
                 Liver Cancer 1025 
                 0.0 
               
               
                   
                 Liver Cancer 6004-T 
                 0.0 
               
               
                   
                 Liver Tissue 6004-N 
                 0.0 
               
               
                   
                 Liver Cancer 6005-T 
                 2.7 
               
               
                   
                 Liver Tissue 6005-N 
                 3.3 
               
               
                   
                 Liver Cancer 064003 
                 7.1 
               
               
                   
                 Normal Bladder 
                 0.0 
               
               
                   
                 Bladder Cancer 1023 
                 0.0 
               
               
                   
                 Bladder Cancer A302173 
                 0.3 
               
               
                   
                 Normal Stomach 
                 5.8 
               
               
                   
                 Gastric Cancer 9060397 
                 0.0 
               
               
                   
                 Stomach Margin 9060396 
                 2.6 
               
               
                   
                 Gastric Cancer 9060395 
                 2.2 
               
               
                   
                 Stomach Margin 9060394 
                 3.4 
               
               
                   
                 Gastric Cancer 064005 
                 0.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3242, Run 174443348    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AYG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 0.0 
                 0.0 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 1.3 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.7 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.0 
                 0.0 
               
               
                   
                 LAK cells IL-2 
                 0.0 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.8 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.8 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 1.5 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.0 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 0.0 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 1.7 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 0.4 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 2.0 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
                 0.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + 
                 0.0 
                 0.0 
               
               
                   
                 IL-1beta 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + 
                 0.0 
                 0.0 
               
               
                   
                 IL-1beta 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
                 0.0 
               
               
                   
                 Small airway epithelium none 
                 0.0 
                 0.0 
               
               
                   
                 Small airway epithelium TNFalpha + 
                 6.5 
                 11.7 
               
               
                   
                 IL-1beta 
               
               
                   
                 Coronery artery SMC rest 
                 0.7 
                 0.0 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
                 0.0 
               
               
                   
                 Astrocytes rest 
                 13.9 
                 16.8 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 3.6 
                 5.3 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.9 
                 1.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 100.0 
                 100.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + 
                 0.0 
                 0.0 
               
               
                   
                 IL-1beta 
               
               
                   
                 Liver cirrhosis 
                 1.9 
                 3.8 
               
               
                   
                 Lupus kidney 
                 1.3 
                 1.4 
               
               
                   
                 NCI-H292 none 
                 42.9 
                 48.0 
               
               
                   
                 NCI-H292 IL-4 
                 14.7 
                 14.8 
               
               
                   
                 NCI-H292 IL-9 
                 40.6 
                 36.6 
               
               
                   
                 NCI-H292 IL-13 
                 12.2 
                 7.4 
               
               
                   
                 NCI-H292 IFN gamma 
                 16.8 
                 10.9 
               
               
                   
                 HPAEC none 
                 0.0 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 0.0 
                 1.7 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                   
                 Lung fibroblast IL-4 
                 1.7 
                 0.0 
               
               
                   
                 Lung fibroblast IL-9 
                 0.0 
                 0.0 
               
               
                   
                 Lung fibroblast IL-13 
                 0.7 
                 0.0 
               
               
                   
                 Lung fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 0.0 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.9 
                 0.0 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 0.0 
                 0.0 
               
               
                   
                 IBD Colitis 2 
                 0.8 
                 2.6 
               
               
                   
                 IBD Crohn&#39;s 
                 0.0 
                 2.0 
               
               
                   
                 Colon 
                 28.1 
                 23.2 
               
               
                   
                 Lung 
                 34.9 
                 51.4 
               
               
                   
                 Thymus 
                 35.1 
                 28.3 
               
               
                   
                 Kidney 
                 8.2 
                 7.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1096, Run 160353275    
               
               
                   
                   Column B - Pel. Exp. (%) Ag3242, Run 164390548    
               
            
           
         
       
     
      AI_comprehensive panel_v1.0 Summary: Ag3242 Expression of this gene was ubiquitous in this panel, with high expression in samples derived from patients suffering from ulcerative colitis, Crohns disease and psoriasis (CTs=33). Significant expression was also seen in samples derived from synovium, cartilage and bone of rheumatoid arthritis. Antibody or small molecule therapies designed with the protein encoded for by this gene are useful in the treatment of inflammatory bowel diseases and rheumatoid arthritis.  
      Panel 1.3D Summary: Ag3242 Highest expression of the CG57448-01 gene was seen in a renal cancer cell line (CT=31.1). Significant expression was also seen in cell lines derived from ovarian cancer, lung cancer, brain cancer and melanoma. Expression of this gene is useful as a marker to differentiate between these samples and other samples on this panel and as a diagnostic marker for the presence of these cancers. This gene encodes a protein that is homologous to cadherin, a cell-adhesion molecule. Therapeutic modulation of the expression or function of this gene or gene prduct is effective in the treatment of lung, renal and melanoma cancers.  
      Expression of the this gene was also high in many regions of the brain, including the amygdala, thalamus, cerebellum, and cerebral cortex, with highest expression in the hippocampus. Expression was also detected in the spinal cord. Cadherins can act as axon guidance and cell adhesion proteins, specifically during development and in the response to injury (Ranscht B. (2000) Int. J. Dev. Neurosci. 18: 643-651.). Manipulation of levels of this protein are of use in inducing a compensatory synaptogenic response to neuronal death in Alzheimer&#39;s disease, Parkinson&#39;s disease, Huntington&#39;s disease, spinocerebellar ataxia, progressive supranuclear palsy, ALS, head trauma, stroke, or any other disease/condition associated with neuronal loss.  
      Among tissues with metabolic function, this gene was moderately expressed in pituitary gland, adrenal gland, thyroid, pancreas, skeletal muscle, and liver, reflecting the widespread role of cadherins in cell-cell adhesion. This expression shows that this gene product plays a role in normal metabolic and neuroendocrine function and that dysregulated expression of this gene contributes to metabolic diseases (such as obesity and diabetes) or neuroendocrine disorders.  
      Panel 2.2 Summary: Ag3242 Highest expression of this gene was seen in a sample derived from an ocular melanoma metastasis (CT=29). Thus, expression of this gene is useful as a marker to differentiate between this sample and other samples on this panel.  
      Panel 4D Summary: Ag1096/Ag3242 Highest expression of this gene was detected in the basophil cell line (KU-812) treated with PMA/ionomycin (CTs=30-32).  
      Significant expression was also seen in a cluster of treated and untreated samples derived from the muco-epidermoid cell line NCI-H292. Thus, this gene, which encodes a cadherin homolog, was expressed in both a cell line that is often used as a model of airway epithelium (NCI-H292) and a cell line that is a reasonable model for the inflammatory cells that contribute to various inflammatory lung diseases. Therapeutic modulation of this gene or gene prodcut may is useful to reduce or eliminate the symptoms of patients suffering from pathological and inflammatory lung disorders, including chronic obstructive pulmonary disease, asthma, allergy and emphysema.  
      Low but significant levels of expression were also seen in the samples derived from normal colon, kidney, lung and thymus. Therapeutic modulation of the expression or function of this gene or gene product is important for maintaining or restoring normal function to this organs during inflammation.  
      AZ. CG58567-01: Protocadherin  
      Expression of gene CG58567-01 was assessed using the primer-probe set Ag2897, described in Table AZA. Results of the RTQ-PCR runs are shown in Tables AZB, AZC, AZD, AZE and AZF.  
               TABLE AZA                          Probe Name Ag2897                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-tgacaggggatattcatgctaa-3′   22   1565   `1540                   Probe   TET-5′-tggcaataaatactgcctcacagtcca-3′-   27   1608   1541           TAMRA               Reverse   5′-agttgcatcacctttgtctttg-3′   22   1638   1542                  
 
     
       
         
           
               
             
               
                 TABLE AZB 
               
             
            
               
                   
               
               
                   
               
               
                 AI_comprehensive panel_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 110967 COPD-F 
                 4.7 
               
               
                   
                 110980 COPD-F 
                 22.5 
               
               
                   
                 110968 COPD-M 
                 8.5 
               
               
                   
                 110977 COPD-M 
                 51.8 
               
               
                   
                 110989 Emphysema-F 
                 51.8 
               
               
                   
                 110992 Emphysema-F 
                 5.0 
               
               
                   
                 110993 Emphysema-F 
                 5.6 
               
               
                   
                 110994 Emphysema-F 
                 3.3 
               
               
                   
                 110995 Emphysema-F 
                 13.2 
               
               
                   
                 110996 Emphysema-F 
                 0.6 
               
               
                   
                 110997 Asthma-M 
                 1.4 
               
               
                   
                 111001 Asthma-F 
                 8.1 
               
               
                   
                 111002 Asthma-F 
                 12.5 
               
               
                   
                 111003 Atopic Asthma-F 
                 12.8 
               
               
                   
                 111004 Atopic Asthma-F 
                 12.3 
               
               
                   
                 111005 Atopic Asthma-F 
                 6.1 
               
               
                   
                 111006 Atopic Asthma-F 
                 3.7 
               
               
                   
                 111417 Allergy-M 
                 7.7 
               
               
                   
                 112347 Allergy-M 
                 0.8 
               
               
                   
                 112349 Normal Lung-F 
                 0.8 
               
               
                   
                 112357 Normal Lung-F 
                 20.2 
               
               
                   
                 112354 Normal Lung-M 
                 2.1 
               
               
                   
                 112374 Crohns-F 
                 4.7 
               
               
                   
                 112389 Match Control Crohns-F 
                 2.1 
               
               
                   
                 112375 Crohns-F 
                 6.7 
               
               
                   
                 112732 Match Control Crohns-F 
                 2.2 
               
               
                   
                 112725 Crohns-M 
                 18.9 
               
               
                   
                 112387 Match Control Crohns-M 
                 11.2 
               
               
                   
                 112378 Crohns-M 
                 1.3 
               
               
                   
                 112390 Match Control Crohns-M 
                 62.4 
               
               
                   
                 112726 Crohns-M 
                 9.6 
               
               
                   
                 112731 Match Control Crohns-M 
                 16.0 
               
               
                   
                 112380 Ulcer Col-F 
                 21.2 
               
               
                   
                 112734 Match Control Ulcer Col-F 
                 4.5 
               
               
                   
                 112384 Ulcer Col-F 
                 17.3 
               
               
                   
                 112737 Match Control Ulcer Col-F 
                 5.2 
               
               
                   
                 112386 Ulcer Col-F 
                 5.3 
               
               
                   
                 112738 Match Control Ulcer Col-F 
                 2.7 
               
               
                   
                 112381 Ulcer Col-M 
                 0.3 
               
               
                   
                 112735 Match Control Ulcer Col-M 
                 23.7 
               
               
                   
                 112382 Ulcer Col-M 
                 5.8 
               
               
                   
                 112394 Match Control Ulcer Col-M 
                 6.5 
               
               
                   
                 112383 Ulcer Col-M 
                 1.6 
               
               
                   
                 112736 Match Control Ulcer Col-M 
                 1.3 
               
               
                   
                 112423 Psoriasis-F 
                 7.9 
               
               
                   
                 112427 Match Control Psoriasis-F 
                 100.0 
               
               
                   
                 112418 Psoriasis-M 
                 2.8 
               
               
                   
                 112723 Match Control Psoriasis-M 
                 14.3 
               
               
                   
                 112419 Psoriasis-M 
                 10.7 
               
               
                   
                 112424 Match Control Psoriasis-M 
                 8.7 
               
               
                   
                 112420 Psoriasis-M 
                 40.1 
               
               
                   
                 112425 Match Control Psoriasis-M 
                 65.1 
               
               
                   
                 104689 (MF) OA Bone-Backus 
                 1.7 
               
               
                   
                 104690 (MF) Adj “Normal” Bone-Backus 
                 4.5 
               
               
                   
                 104691 (MF) OA Synovium-Backus 
                 9.5 
               
               
                   
                 104692 (BA) OA Cartilage-Backus 
                 3.1 
               
               
                   
                 104694 (BA) OA Bone-Backus 
                 1.3 
               
               
                   
                 104695 (BA) Adj “Normal” Bone-Backus 
                 1.8 
               
               
                   
                 104696 (BA) OA Synovium-Backus 
                 5.0 
               
               
                   
                 104700 (SS) OA Bone-Backus 
                 5.2 
               
               
                   
                 104701 (SS) Adj “Normal” Bone-Backus 
                 7.0 
               
               
                   
                 104702 (SS) OA Synovium-Backus 
                 12.7 
               
               
                   
                 117093 OA Cartilage Rep7 
                 15.1 
               
               
                   
                 112672 OA Bone5 
                 15.9 
               
               
                   
                 112673 OA Synovium5 
                 8.2 
               
               
                   
                 112674 OA Synovia Fluid cells5 
                 7.9 
               
               
                   
                 117100 OA Cartilage Rep14 
                 1.3 
               
               
                   
                 112756 OA Bone9 
                 0.8 
               
               
                   
                 112757 OA Synovium9 
                 0.4 
               
               
                   
                 112758 OA Synovial Fluid Cells9 
                 10.2 
               
               
                   
                 117125 RA Cartilage Rep2 
                 6.5 
               
               
                   
                 113492 Bone2 RA 
                 2.2 
               
               
                   
                 113493 Synovium2 RA 
                 0.2 
               
               
                   
                 113494 Syn Fluid Cells RA 
                 2.0 
               
               
                   
                 113499 Cartilage4 RA 
                 1.6 
               
               
                   
                 113500 Bone4 RA 
                 1.3 
               
               
                   
                 113501 Synovium4 RA 
                 1.9 
               
               
                   
                 113502 Syn Fluid Cells4 RA 
                 1.0 
               
               
                   
                 113495 Cartilage3 RA 
                 1.1 
               
               
                   
                 113496 Bone3 RA 
                 1.4 
               
               
                   
                 113497 Synovium3 RA 
                 0.2 
               
               
                   
                 113498 Syn Fluid Cells3 RA 
                 1.2 
               
               
                   
                 117106 Normal Cartilage Rep20 
                 0.3 
               
               
                   
                 113663 Bone3 Normal 
                 2.8 
               
               
                   
                 113664 Synovium3 Normal 
                 0.2 
               
               
                   
                 113665 Syn Fluid Cells3 Normal 
                 1.3 
               
               
                   
                 117107 Normal Cartilage Rep22 
                 9.2 
               
               
                   
                 113667 Bone4 Normal 
                 9.5 
               
               
                   
                 113668 Synovium4 Normal 
                 6.1 
               
               
                   
                 113669 Syn Fluid Cells4 Normal 
                 10.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2897, Run 229662505    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AZC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 0.0 
                 0.0 
               
               
                   
                 Pancreas 
                 1.4 
                 2.4 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
                 0.0 
               
               
                   
                 Adrenal gland 
                 1.4 
                 0.0 
               
               
                   
                 Thyroid 
                 0.0 
                 0.0 
               
               
                   
                 Salivary gland 
                 0.0 
                 0.0 
               
               
                   
                 Pituitary gland 
                 4.1 
                 9.0 
               
               
                   
                 Brain (fetal) 
                 7.1 
                 17.8 
               
               
                   
                 Brain (whole) 
                 21.0 
                 59.0 
               
               
                   
                 Brain (amygdala) 
                 24.7 
                 37.9 
               
               
                   
                 Brain (cerebellum) 
                 5.6 
                 28.5 
               
               
                   
                 Brain (hippocampus) 
                 25.2 
                 25.3 
               
               
                   
                 Brain (substantia nigra) 
                 0.9 
                 17.1 
               
               
                   
                 Brain (thalamus) 
                 4.1 
                 23.0 
               
               
                   
                 Cerebral Cortex 
                 100.0 
                 22.2 
               
               
                   
                 Spinal cord 
                 68.8 
                 100.0 
               
               
                   
                 glio/astro U87-MG 
                 54.3 
                 10.4 
               
               
                   
                 glio/astro U-118-MG 
                 1.5 
                 20.4 
               
               
                   
                 astrocytoma SW 1783 
                 16.3 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
                 4.3 
               
               
                   
                 astrocytoma SNB-75 
                 18.4 
                 28.7 
               
               
                   
                 glioma SNB-19 
                 0.0 
                 2.6 
               
               
                   
                 glioma U251 
                 3.1 
                 27.0 
               
               
                   
                 glioma SF-295 
                 4.8 
                 2.2 
               
               
                   
                 Heart (fetal) 
                 0.0 
                 0.0 
               
               
                   
                 Heart 
                 1.4 
                 0.0 
               
               
                   
                 Skeletal muscle (fetal) 
                 77.4 
                 0.0 
               
               
                   
                 Skeletal muscle 
                 1.1 
                 14.1 
               
               
                   
                 Bone marrow 
                 0.0 
                 2.5 
               
               
                   
                 Thymus 
                 2.1 
                 2.4 
               
               
                   
                 Spleen 
                 0.0 
                 4.4 
               
               
                   
                 Lymph node 
                 0.0 
                 4.8 
               
               
                   
                 Colorectal 
                 10.7 
                 0.0 
               
               
                   
                 Stomach 
                 8.7 
                 64.6 
               
               
                   
                 Small intestine 
                 7.2 
                 18.9 
               
               
                   
                 Colon ca. SW480 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 1.7 
                 8.1 
               
               
                   
                 Colon ca. HCC-2998 
                 0.0 
                 0.0 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 10.3 
                 7.7 
               
               
                   
                 Bladder 
                 14.2 
                 29.3 
               
               
                   
                 Trachea 
                 4.1 
                 0.0 
               
               
                   
                 Kidney 
                 0.0 
                 0.0 
               
               
                   
                 Kidney (fetal) 
                 2.8 
                 2.4 
               
               
                   
                 Renal ca. 786-0 
                 0.9 
                 3.3 
               
               
                   
                 Renal ca. A498 
                 13.9 
                 23.7 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
                 2.9 
               
               
                   
                 Liver (fetal) 
                 0.4 
                 0.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
                 0.0 
               
               
                   
                 Lung 
                 1.4 
                 0.0 
               
               
                   
                 Lung (fetal) 
                 6.8 
                 11.0 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
                 4.1 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 1.0 
                 0.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
                 3.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.6 
                 7.5 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 4.6 
                 8.6 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
                 0.0 
               
               
                   
                 Mammary gland 
                 7.9 
                 17.1 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
                 14.5 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
                 12.2 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
                 0.0 
               
               
                   
                 Ovary 
                 12.1 
                 6.1 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 3.8 
                 12.1 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 32.5 
                 25.5 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 1.9 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.0 
                 0.0 
               
               
                   
                 Uterus 
                 12.4 
                 66.4 
               
               
                   
                 Placenta 
                 0.0 
                 2.3 
               
               
                   
                 Prostate 
                 0.0 
                 0.0 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 0.0 
                 0.0 
               
               
                   
                 Testis 
                 56.3 
                 68.8 
               
               
                   
                 Melanoma Hs688(A).T 
                 1.3 
                 8.2 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 2.5 
                 4.8 
               
               
                   
                 Melanoma UACC-62 
                 1.5 
                 2.8 
               
               
                   
                 Melanoma M14 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
                 0.0 
               
               
                   
                 Adipose 
                 7.2 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2897, Run 161905860    
               
               
                   
                   Column B - Rel. Exp. (%) Ag2897, Run 165518166    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AZD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Normal Colon 
                 83.5 
                 90.1 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 0.0 
                 7.2 
               
               
                   
                 CC Margin (ODO3866) 
                 16.0 
                 16.6 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 0.0 
                 0.0 
               
               
                   
                 CC Margin (ODO3868) 
                 6.3 
                 3.6 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 0.9 
                 2.1 
               
               
                   
                 CC Margin (ODO3920) 
                 19.1 
                 11.7 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 8.8 
                 9.2 
               
               
                   
                 CC Margin (ODO3921) 
                 6.9 
                 7.5 
               
               
                   
                 CC from Partial Hepatectomy 
                 0.9 
                 3.3 
               
               
                   
                 (ODO4309) Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 0.7 
                 2.0 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 0.0 
                 0.0 
               
               
                   
                 Lung Margin (OD04451-02) 
                 1.9 
                 1.0 
               
               
                   
                 Normal Prostate 6546-1 
                 3.9 
                 10.7 
               
               
                   
                 Prostate Cancer (OD04410) 
                 17.3 
                 11.6 
               
               
                   
                 Prostate Margin (OD04410) 
                 25.0 
                 15.5 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 28.3 
                 11.7 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 29.9 
                 20.4 
               
               
                   
                 Normal Lung 061010 
                 16.2 
                 15.1 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 1.2 
                 0.0 
               
               
                   
                 Muscle Margin (ODO4286) 
                 8.2 
                 1.6 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 7.0 
                 2.2 
               
               
                   
                 Lung Margin (OD03126) 
                 2.3 
                 3.0 
               
               
                   
                 Lung Cancer (OD04404) 
                 8.2 
                 3.1 
               
               
                   
                 Lung Margin (OD04404) 
                 11.1 
                 10.2 
               
               
                   
                 Lung Cancer (OD04565) 
                 0.0 
                 0.9 
               
               
                   
                 Lung Margin (OD04565) 
                 1.9 
                 5.0 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 95.3 
                 55.9 
               
               
                   
                 Lung Margin (OD04237-02) 
                 4.0 
                 2.3 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 0.0 
                 0.0 
               
               
                   
                 Liver Margin (ODO4310) 
                 2.7 
                 0.8 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.0 
                 1.7 
               
               
                   
                 Lung Margin (OD04321) 
                 10.1 
                 6.6 
               
               
                   
                 Normal Kidney 
                 14.8 
                 16.4 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 93.3 
                 100.0 
               
               
                   
                 Kidney Margin (OD04338) 
                 14.3 
                 2.0 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 5.0 
                 2.0 
               
               
                   
                 Kidney Margin (OD04339) 
                 4.1 
                 3.0 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 27.0 
                 17.4 
               
               
                   
                 Kidney Margin (OD04340) 
                 6.4 
                 12.7 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 1.9 
                 2.1 
               
               
                   
                 Kidney Margin (OD04348) 
                 4.7 
                 6.2 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 50.0 
                 38.4 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 4.2 
                 0.0 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 2.6 
                 3.6 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 14.2 
                 10.5 
               
               
                   
                 Kidney Cancer 8120607 
                 1.9 
                 0.0 
               
               
                   
                 Kidney Margin 8120608 
                 1.3 
                 0.9 
               
               
                   
                 Kidney Cancer 8120613 
                 1.4 
                 1.6 
               
               
                   
                 Kidney Margin 8120614 
                 0.9 
                 1.5 
               
               
                   
                 Kidney Cancer 9010320 
                 21.6 
                 16.0 
               
               
                   
                 Kidney Margin 9010321 
                 1.9 
                 0.5 
               
               
                   
                 Normal Uterus 
                 9.5 
                 10.9 
               
               
                   
                 Uterus Cancer 064011 
                 68.3 
                 71.2 
               
               
                   
                 Normal Thyroid 
                 3.3 
                 0.8 
               
               
                   
                 Thyroid Cancer 064010 
                 2.0 
                 6.9 
               
               
                   
                 Thyroid Cancer A302152 
                 8.9 
                 12.2 
               
               
                   
                 Thyroid Margin A302153 
                 1.0 
                 0.7 
               
               
                   
                 Normal Breast 
                 15.9 
                 15.3 
               
               
                   
                 Breast Cancer (OD04566) 
                 4.3 
                 6.3 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 7.3 
                 2.8 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 9.4 
                 4.8 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 3.6 
                 0.9 
               
               
                   
                 Breast Cancer 064006 
                 8.4 
                 11.6 
               
               
                   
                 Breast Cancer 1024 
                 2.6 
                 4.3 
               
               
                   
                 Breast Cancer 9100266 
                 1.9 
                 2.0 
               
               
                   
                 Breast Margin 9100265 
                 7.4 
                 5.4 
               
               
                   
                 Breast Cancer A209073 
                 20.0 
                 13.6 
               
               
                   
                 Breast Margin A209073 
                 5.0 
                 12.0 
               
               
                   
                 Normal Liver 
                 0.9 
                 1.0 
               
               
                   
                 Liver Cancer 064003 
                 0.0 
                 0.0 
               
               
                   
                 Liver Cancer 1025 
                 2.4 
                 0.0 
               
               
                   
                 Liver Cancer 1026 
                 0.0 
                 0.0 
               
               
                   
                 Liver Cancer 6004-T 
                 0.0 
                 1.0 
               
               
                   
                 Liver Tissue 6004-N 
                 0.0 
                 0.0 
               
               
                   
                 Liver Cancer 6005-T 
                 0.0 
                 0.0 
               
               
                   
                 Liver Tissue 6005-N 
                 0.0 
                 0.0 
               
               
                   
                 Normal Bladder 
                 18.0 
                 13.8 
               
               
                   
                 Bladder Cancer 1023 
                 1.0 
                 0.7 
               
               
                   
                 Bladder Cancer A302173 
                 10.9 
                 2.6 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 0.0 
                 1.9 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 33.2 
                 31.0 
               
               
                   
                 Normal Ovary 
                 0.0 
                 4.8 
               
               
                   
                 Ovarian Cancer 064008 
                 100.0 
                 62.0 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 49.7 
                 38.7 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 6.3 
                 2.5 
               
               
                   
                 Normal Stomach 
                 28.1 
                 18.7 
               
               
                   
                 Gastric Cancer 9060358 
                 11.0 
                 14.1 
               
               
                   
                 Stomach Margin 9060359 
                 15.9 
                 29.7 
               
               
                   
                 Gastric Cancer 9060395 
                 15.0 
                 6.8 
               
               
                   
                 Stomach Margin 9060394 
                 26.6 
                 26.4 
               
               
                   
                 Gastric Cancer 9060397 
                 2.7 
                 1.7 
               
               
                   
                 Stomach Margin 9060396 
                 28.1 
                 33.0 
               
               
                   
                 Gastric Cancer 064005 
                 27.7 
                 33.4 
               
               
                   
                   
               
               
                   
                   Column A - Pel. Exp. (%) Ag2897, Run 161905861    
               
               
                   
                   Column B - Rel. Exp. (%) Ag2897, Run 164997312    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AZE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Daoy- Medulloblastoma 
                 0.0 
               
               
                   
                 TE671- Medulloblastoma 
                 0.0 
               
               
                   
                 D283 Med- Medulloblastoma 
                 0.0 
               
               
                   
                 PFSK-1- Primitive Neuroectodermal 
                 0.0 
               
               
                   
                 XF-498- CNS 
                 0.6 
               
               
                   
                 SNB-78- Glioma 
                 6.0 
               
               
                   
                 SF-268- Glioblastoma 
                 0.0 
               
               
                   
                 T98G- Glioblastoma 
                 0.0 
               
               
                   
                 SK-N-SH- Neuroblastoma (metastasis) 
                 0.0 
               
               
                   
                 SF-295- Glioblastoma 
                 0.0 
               
               
                   
                 Cerebellum 
                 7.1 
               
               
                   
                 Cerebellum 
                 0.0 
               
               
                   
                 NCI-H292- Mucoepidermoid lung carcinoma 
                 0.0 
               
               
                   
                 DMS-114- Small cell lung cancer 
                 0.0 
               
               
                   
                 DMS-79- Small cell lung cancer 
                 0.8 
               
               
                   
                 NCI-H146- Small cell lung cancer 
                 1.3 
               
               
                   
                 NCI-H526- Small cell lung cancer 
                 100.0 
               
               
                   
                 NCI-N417- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H82- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H157- Squamous cell lung cancer (metastasis) 
                 0.0 
               
               
                   
                 NCI-H1155- Large cell lung cancer 
                 3.2 
               
               
                   
                 NCI-H1299- Large cell lung cancer 
                 1.9 
               
               
                   
                 NCI-H727- Lung carcinoid 
                 0.0 
               
               
                   
                 NCI-UMC-11- Lung carcinoid 
                 2.1 
               
               
                   
                 LX-1- Small cell lung cancer 
                 0.0 
               
               
                   
                 Colo-205- Colon cancer 
                 0.0 
               
               
                   
                 KM12- Colon cancer 
                 2.6 
               
               
                   
                 KM20L2- Colon cancer 
                 0.0 
               
               
                   
                 NCI-H716- Colon cancer 
                 31.0 
               
               
                   
                 SW-48- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW1116- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 LS 174T- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-948- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-480- Colon adenocarcinoma 
                 1.5 
               
               
                   
                 NCI-SNU-5- Gastric carcinoma 
                 0.0 
               
               
                   
                 KATO III- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-16- Gastric carcinoma 
                 0.8 
               
               
                   
                 NCI-SNU-1- Gastric carcinoma 
                 0.0 
               
               
                   
                 RF-1- Gastric adenocarcinoma 
                 0.0 
               
               
                   
                 RF-48- Gastric adenocarcinoma 
                 0.8 
               
               
                   
                 MKN-45- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-N87- Gastric carcinoma 
                 0.3 
               
               
                   
                 OVCAR-5- Ovarian carcinoma 
                 0.0 
               
               
                   
                 RL95-2- Uterine carcinoma 
                 0.0 
               
               
                   
                 HelaS3- Cervical adenocarcinoma 
                 0.0 
               
               
                   
                 Ca Ski- Cervical epidermoid carcinoma (metastasis) 
                 0.0 
               
               
                   
                 ES-2- Ovarian clear cell carcinoma 
                 0.8 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 0.0 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 0.0 
               
               
                   
                 MEG-01- Chronic myelogenous leukemia 
                 0.0 
               
               
                   
                 (megokaryoblast) 
               
               
                   
                 Raji- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 Daudi- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 U266- B-cell plasmacytoma 
                 0.0 
               
               
                   
                 CA46- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 0.0 
               
               
                   
                 JM1- pre-B-cell lymphoma 
                 0.0 
               
               
                   
                 Jurkat- T cell leukemia 
                 0.0 
               
               
                   
                 TF-1- Erythroleukemia 
                 0.0 
               
               
                   
                 HUT 78- T-cell lymphoma 
                 0.0 
               
               
                   
                 U937- Histiocytic lymphoma 
                 0.0 
               
               
                   
                 KU-812- Myelogenous leukemia 
                 0.0 
               
               
                   
                 769-P- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 Caki-2- Clear cell renal carcinoma 
                 0.9 
               
               
                   
                 SW 839- Clear cell renal carcinoma 
                 0.0 
               
               
                   
                 Rhabdoid kidney tumor 
                 0.0 
               
               
                   
                 Hs766T- Pancreatic carcinoma (LN metastasis) 
                 0.0 
               
               
                   
                 CAPAN-1- Pancreatic adenocarcinoma (liver 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 SU86.86- Pancreatic carcinoma (liver metastasis) 
                 0.6 
               
               
                   
                 BxPC-3- Pancreatic adenocarcinoma 
                 0.0 
               
               
                   
                 HPAC- Pancreatic adenocarcinoma 
                 0.0 
               
               
                   
                 MIA PaCa-2- Pancreatic carcinoma 
                 0.0 
               
               
                   
                 CFPAC-1- Pancreatic ductal adenocarcinoma 
                 0.4 
               
               
                   
                 PANC-1- Pancreatic epithelioid ductal carcinoma 
                 0.0 
               
               
                   
                 T24- Bladder carcinma (transitional cell) 
                 0.0 
               
               
                   
                 5637- Bladder carcinoma 
                 0.0 
               
               
                   
                 HT-1197- Bladder carcinoma 
                 0.0 
               
               
                   
                 UM-UC-3- Bladder carcinma (transitional cell) 
                 0.0 
               
               
                   
                 A204- Rhabdomyosarcoma 
                 0.0 
               
               
                   
                 HT-1080- Fibrosarcoma 
                 0.8 
               
               
                   
                 MG-63- Osteosarcoma 
                 0.0 
               
               
                   
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 0.0 
               
               
                   
                 SJRH30- Rhabdomyosarcoma (met to bone marrow) 
                 0.0 
               
               
                   
                 A431- Epidermoid carcinoma 
                 0.0 
               
               
                   
                 WM266-4- Melanoma 
                 1.2 
               
               
                   
                 DU 145- Prostate carcinoma (brain metastasis) 
                 0.0 
               
               
                   
                 MDA-MB-468- Breast adenocarcinoma 
                 0.8 
               
               
                   
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-9- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 CAL 27- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2897, Run 164629841    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE AZF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 9.3 
                 20.7 
               
               
                   
                 Primary Th2 rest 
                 0.0 
                 9.0 
               
               
                   
                 Primary Tr1 rest 
                 9.8 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 0.0 
                 0.0 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
                 0.0 
               
               
                   
                 LAK cells rest 
                 10.9 
                 0.0 
               
               
                   
                 LAK cells IL-2 
                 0.0 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
                 9.3 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.0 
                 0.0 
               
               
                   
                 PBMC PWM 
                 0.0 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 8.9 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 0.0 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
                 0.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + 
                 7.9 
                 22.8 
               
               
                   
                 IL-1beta 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + 
                 16.2 
                 0.0 
               
               
                   
                 IL-1beta 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 4.4 
                 0.0 
               
               
                   
                 Small airway epithelium none 
                 10.4 
                 9.7 
               
               
                   
                 Small airway epithelium TNFalpha + 
                 100.0 
                 75.8 
               
               
                   
                 IL-1beta 
               
               
                   
                 Coronery artery SMC rest 
                 0.0 
                 9.9 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 16.8 
                 9.0 
               
               
                   
                 Astrocytes rest 
                 40.6 
                 0.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 56.6 
                 100.0 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + 
                 0.0 
                 0.0 
               
               
                   
                 IL-1beta 
               
               
                   
                 Liver cirrhosis 
                 17.2 
                 8.2 
               
               
                   
                 Lupus kidney 
                 8.4 
                 9.6 
               
               
                   
                 NCI-H292 none 
                 0.0 
                 0.0 
               
               
                   
                 NCI-H292 IL-4 
                 0.0 
                 0.0 
               
               
                   
                 NCI-H292 IL-9 
                 0.0 
                 0.0 
               
               
                   
                 NCI-H292 IL-13 
                 0.0 
                 0.0 
               
               
                   
                 NCI-H292 IFN gamma 
                 0.0 
                 0.0 
               
               
                   
                 HPAEC none 
                 0.0 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 0.0 
                 0.0 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
                 18.8 
               
               
                   
                 Lung fibroblast IL-4 
                 0.0 
                 17.7 
               
               
                   
                 Lung fibroblast IL-9 
                 0.0 
                 0.0 
               
               
                   
                 Lung fibroblast IL-13 
                 0.0 
                 0.0 
               
               
                   
                 Lung fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 18.7 
                 5.1 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 45.4 
                 29.5 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 33.7 
                 85.9 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 0.0 
                 0.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 0.0 
                 8.4 
               
               
                   
                 IBD Colitis 2 
                 0.0 
                 9.9 
               
               
                   
                 IBD Crohn&#39;s 
                 7.7 
                 0.0 
               
               
                   
                 Colon 
                 62.4 
                 39.2 
               
               
                   
                 Lung 
                 9.9 
                 22.1 
               
               
                   
                 Thymus 
                 27.7 
                 35.8 
               
               
                   
                 Kidney 
                 18.9 
                 20.6 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2897, Run 161905862    
               
               
                   
                   Column B - Rel. Exp. (%) Ag2897, Run 163586314    
               
            
           
         
       
     
      AI_comprehensive panel_v1.0 Summary: Ag2897 Highest expression of this gene was detected in a normal tissue sample adjacent to a psoriasis sample (CT=30). This expression was down-regulated in the corresponding psoriasis sample (CT=33). Expression of this gene is useful as a marker to distinguish between these samples. The expression of this gene was up-regulated in lung from emphysema and COPD patients, consistent with its expression in “stressed” small airway epithelium, lung fibroblasts and lung endothelium (treated with TNF-a and IL-1). Therapeutic modulation of the expression of this gene or its protein and/or signaling via this protein by antibodies, small moleculesvor protein therapeutics is useful for the inhibition of inflammation in lung tissue due to asthma, emphysema and other COPD type diseases  
      Panel 1.3D Summary: Ag2897 Highest expression of this gene, a protocadherin homolog, was detected in the spinal cord and the cerebral cortex (CTs=31.5). Low levels of expression were also seen in other regions of the brain including the amygdala and the hippocampus. The cadherins have been shown to be critical for CNS development, specifically for the guidance of axons, dendrites and/or growth cones in general. Therapeutic modulation of the levels of this protein, or possible signaling via this protein are of utility in enhancing/directing compensatory synaptogenesis and fiber growth in the CNS in response to neuronal death (stroke, head trauma), axon lesion (spinal cord injury), or neurodegeneration (Alzheimer&#39;s, Parkinson&#39;s, Huntington&#39;s, vascular dementia or any neurodegenerative disease). Since protocadherins play an important role in synaptogenesis, this gene product is also involved in depression, schizophrenia, both of which involve synaptogeneisis. Because this cadherin shows highest expression in the cerebellum, this is also an excellent candidate for the spinocerebellar ataxias as well.  
      Significant levels of expression were also seen in cell lines derived from ovarian, renal and brain cancers. Thus, expression of this gene or gene product is useful as a marker to differentiate between these samples and other samples on this panel and as a marker to detect the presence of these cancers. Therapeutic modulation of the expression or function of this gene or gene product is effective in the treatment of ovarian, renal and brain cancers.  
      Panel 2D Summary: Ag2897 Highest expression of this gene was detected in ovarian and kidney cancers (CTs=30.5). Significant levels of expression were also seen in lung and uterine cancers. Higher levels of expression were seen in these cancers than in the corresponding normal adjacent tissues. Therapeutic targeting of this gene or gene product with a small molecule drug, protein therapeutic, or human monoclonal antibody is useful for limiting or blocking the extent of tumor cell migration and invasion, preferably in kidney, lung, uterine and ovarian tumor tumors.  
      Panel 3D Summary: Ag2897 Highest expression of this gene was seen in a lung cancer cell line (CT=30. 1). Expression of this gene or gene product is useful as a marker to differentiate between this sample and other samples on this panel.  
      Panel 4D Summary: Ag2897 This gene highly was up-regulated in small airway epithelium and astrocytes stimulated with TNF-alpha and IL-1 beta (CTs=33-34). Other tissues in the lung also up regulated the expression of this gene including lung microvascular endothelium and lung fibroblasts in response to TNF alpha or the Th2 elaborated cytokine IL-4. This demonstrates that this molecule is expressed as a result of inflammation, particularly during asthma since TNFalpha and IL-4 may play important roles in the pathology of this disease. Based on the expression profile of this transcript and the types of cytokines which induce it, antibodies, protein therapeutics or small molecule drugs that target this gene or gene product are useful for inhibiting inflammation in lung tissue due to asthma, emphysema and other COPD type diseases.  
      BA. CG59534-03: Ovostatin  
      Expression of gene CG59534-03 was assessed using the primer-probe set  
      Ag7218, described in Table BAA. Results of the RTQ-PCR runs are shown in Table BAB.  
               TABLE BAA                          Probe Name Ag7218                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-ctacaggaagtgcagcacaac-3′   21   294   1543                   Probe   TET-5′-agccagctgaaggcctacctttcctt-3′-   26   336   1544           TAMRA               Reverse   5′-gttgttcaaactcagatctaacacttct-3′   28   362   1545                  
 
     
       
         
           
               
             
               
                 TABLE BAB 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 31.6 
               
               
                   
                 Secondary Th2 act 
                 27.4 
               
               
                   
                 Secondary Tr1 act 
                 14.4 
               
               
                   
                 Secondary Th1 rest 
                 7.4 
               
               
                   
                 Secondary Th2 rest 
                 6.6 
               
               
                   
                 Secondary Tr1 rest 
                 6.0 
               
               
                   
                 Primary Th1 act 
                 9.0 
               
               
                   
                 Primary Th2 act 
                 40.1 
               
               
                   
                 Primary Tr1 act 
                 39.8 
               
               
                   
                 Primary Th1 rest 
                 3.9 
               
               
                   
                 Primary Th2 rest 
                 1.6 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 31.4 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 39.8 
               
               
                   
                 CD8 lymphocyte act 
                 24.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 90.8 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 9.5 
               
               
                   
                 CD4 lymphocyte none 
                 7.5 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 11.7 
               
               
                   
                 LAK cells rest 
                 20.0 
               
               
                   
                 LAK cells IL-2 
                 6.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 3.6 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 26.6 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 10.4 
               
               
                   
                 LAK cells PMA/ionomycin 
                 52.1 
               
               
                   
                 NK Cells IL-2 rest 
                 52.9 
               
               
                   
                 Two Way MLR 3 day 
                 12.2 
               
               
                   
                 Two Way MLR 5 day 
                 9.6 
               
               
                   
                 Two Way MLR 7 day 
                 11.9 
               
               
                   
                 PBMC rest 
                 2.5 
               
               
                   
                 PBMC PWM 
                 21.8 
               
               
                   
                 PBMC PHA-L 
                 18.8 
               
               
                   
                 Ramos (B cell) none 
                 54.7 
               
               
                   
                 Ramos (B cell) ionomycin 
                 79.6 
               
               
                   
                 B lymphocytes PWM 
                 13.9 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 16.5 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 1.3 
               
               
                   
                 Dendritic cells none 
                 5.9 
               
               
                   
                 Dendritic cells LPS 
                 0.7 
               
               
                   
                 Dendritic cells anti-CD40 
                 1.3 
               
               
                   
                 Monocytes rest 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 5.7 
               
               
                   
                 Macrophages rest 
                 1.1 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 17.1 
               
               
                   
                 HUVEC starved 
                 45.1 
               
               
                   
                 HUVEC IL-1beta 
                 45.7 
               
               
                   
                 HUVEC IFN gamma 
                 26.8 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 12.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 26.4 
               
               
                   
                 HUVEC IL-11 
                 27.0 
               
               
                   
                 Lung Microvascular EC none 
                 28.5 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 15.5 
               
               
                   
                 Microvascular Dermal EC none 
                 8.2 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 6.9 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 12.9 
               
               
                   
                 Small airway epithelium none 
                 5.1 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 10.5 
               
               
                   
                 Coronery artery SMC rest 
                 15.8 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 29.3 
               
               
                   
                 Astrocytes rest 
                 15.2 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 17.2 
               
               
                   
                 KU-812 (Basophil) rest 
                 5.8 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 11.7 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 15.5 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 8.0 
               
               
                   
                 Liver cirrhosis 
                 8.0 
               
               
                   
                 NCI-H292 none 
                 2.7 
               
               
                   
                 NCI-H292 IL-4 
                 2.0 
               
               
                   
                 NCI-H292 IL-9 
                 8.9 
               
               
                   
                 NCI-H292 IL-13 
                 2.0 
               
               
                   
                 NCI-H292 IFN gamma 
                 5.3 
               
               
                   
                 HPAEC none 
                 21.5 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 100.0 
               
               
                   
                 Lung fibroblast none 
                 77.9 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 93.3 
               
               
                   
                 Lung fibroblast IL-4 
                 33.4 
               
               
                   
                 Lung fibroblast IL-9 
                 62.4 
               
               
                   
                 Lung fibroblast IL-13 
                 40.9 
               
               
                   
                 Lung fibroblast IFN gamma 
                 54.7 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 8.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 29.3 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 76.3 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 7.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 26.1 
               
               
                   
                 Dermal Fibroblasts rest 
                 15.8 
               
               
                   
                 Neutrophils TNFa + LPS 
                 0.0 
               
               
                   
                 Neutrophils rest 
                 2.9 
               
               
                   
                 Colon 
                 3.6 
               
               
                   
                 Lung 
                 6.3 
               
               
                   
                 Thymus 
                 4.7 
               
               
                   
                 Kidney 
                 13.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag7218, Run 288211130    
               
            
           
         
       
     
      Panel 4.1D Summary: Ag7218 Highest expression of this gene was seen in human pulmonary artery endothelial cells (CT=32). Detectable levels of expression were also seen in clusters of lung and dermal fibroblasts as well as in activated T cells. Therefore, targeting this gene or its protein product is useful for the reduction or elimination of the inflammation in lung, skin, and T cell mediated inflammatory and autoimmune diseases.  
      BB. CG59584-02 and CG59584-03: Ovastatin  
      Expression of gene CG59584-03 was assessed using the primer-probe set Ag1282, described in Table BBA. Results of the RTQ-PCR runs are shown in Tables BBB, BBC, BBD, BBE, BBF, and BBG.  
               TABLE BBA                          Probe Name Ag1282                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-ttcgcaataaatccagtatggt-3′   22   4510   1546                   Probe   TET-5′-tgctatcaggatttactccaaccatgtca-3′-   29   4549   1547           TAMRA               Reverse   5′-ttgttttcaagctcttcaatgg-3′   22   4579   1548                  
 
     
       
         
           
               
             
               
                 TABLE BBB 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 0.5 
               
               
                   
                 Melanoma* Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma* M14 
                 100.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.9 
               
               
                   
                 Melanoma* SK-MEL-5 
                 11.2 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.0 
               
               
                   
                 Testis Pool 
                 5.3 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Prostate Pool 
                 0.3 
               
               
                   
                 Placenta 
                 0.4 
               
               
                   
                 Uterus Pool 
                 0.2 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 2.1 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.7 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.2 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.8 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.2 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.1 
               
               
                   
                 Ovary 
                 0.6 
               
               
                   
                 Breast ca. MCF-7 
                 0.3 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.6 
               
               
                   
                 Breast ca. BT 549 
                 0.9 
               
               
                   
                 Breast ca. T47D 
                 0.8 
               
               
                   
                 Breast ca. MDA-N 
                 45.1 
               
               
                   
                 Breast Pool 
                 0.7 
               
               
                   
                 Trachea 
                 0.5 
               
               
                   
                 Lung 
                 0.3 
               
               
                   
                 Fetal Lung 
                 4.9 
               
               
                   
                 Lung ca. NCI-N417 
                 0.0 
               
               
                   
                 Lung ca. LX-1 
                 1.6 
               
               
                   
                 Lung ca. NCI-H146 
                 2.3 
               
               
                   
                 Lung ca. SHP-77 
                 1.1 
               
               
                   
                 Lung ca. A549 
                 1.1 
               
               
                   
                 Lung ca. NCI-H526 
                 0.4 
               
               
                   
                 Lung ca. NCI-H23 
                 2.8 
               
               
                   
                 Lung ca. NCI-H460 
                 0.1 
               
               
                   
                 Lung ca. HOP-62 
                 0.7 
               
               
                   
                 Lung ca. NCI-H522 
                 2.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Fetal Liver 
                 0.9 
               
               
                   
                 Liver ca. HepG2 
                 0.3 
               
               
                   
                 Kidney Pool 
                 1.0 
               
               
                   
                 Fetal Kidney 
                 3.6 
               
               
                   
                 Renal ca. 786-0 
                 0.6 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.6 
               
               
                   
                 Renal ca. UO-31 
                 0.1 
               
               
                   
                 Renal ca. TK-10 
                 1.1 
               
               
                   
                 Bladder 
                 0.4 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 1.7 
               
               
                   
                 Gastric ca. KATO III 
                 1.2 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 3.3 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 1.5 
               
               
                   
                 Colon ca. HT29 
                 0.4 
               
               
                   
                 Colon ca. HCT-116 
                 2.5 
               
               
                   
                 Colon ca. CaCo-2 
                 0.6 
               
               
                   
                 Colon cancer tissue 
                 0.5 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.1 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 0.5 
               
               
                   
                 Small Intestine Pool 
                 1.4 
               
               
                   
                 Stomach Pool 
                 0.2 
               
               
                   
                 Bone Marrow Pool 
                 0.2 
               
               
                   
                 Fetal Heart 
                 1.6 
               
               
                   
                 Heart Pool 
                 0.2 
               
               
                   
                 Lymph Node Pool 
                 0.4 
               
               
                   
                 Fetal Skeletal Muscle 
                 1.6 
               
               
                   
                 Skeletal Muscle Pool 
                 0.1 
               
               
                   
                 Spleen Pool 
                 0.8 
               
               
                   
                 Thymus Pool 
                 2.5 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 0.4 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 0.3 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 0.5 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.1 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 9.0 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 0.2 
               
               
                   
                 CNS cancer (glio) SF-295 
                 0.7 
               
               
                   
                 Brain (Amygdala) Pool 
                 0.9 
               
               
                   
                 Brain (cerebellum) 
                 0.6 
               
               
                   
                 Brain (fetal) 
                 2.9 
               
               
                   
                 Brain (Hippocampus) Pool 
                 1.0 
               
               
                   
                 Cerebral Cortex Pool 
                 1.1 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 0.8 
               
               
                   
                 Brain (Thalamus) Pool 
                 1.1 
               
               
                   
                 Brain (whole) 
                 0.8 
               
               
                   
                 Spinal Cord Pool 
                 0.5 
               
               
                   
                 Adrenal Gland 
                 0.1 
               
               
                   
                 Pituitary gland Pool 
                 0.1 
               
               
                   
                 Salivary Gland 
                 0.1 
               
               
                   
                 Thyroid (female) 
                 0.1 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 1.3 
               
               
                   
                 Pancreas Pool 
                 0.9 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1282, Run 216588406    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BBC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 9.2 
               
               
                   
                 Pancreas 
                 0.5 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 1.3 
               
               
                   
                 Adrenal gland 
                 0.3 
               
               
                   
                 Thyroid 
                 0.3 
               
               
                   
                 Salivary gland 
                 0.1 
               
               
                   
                 Pituitary gland 
                 0.3 
               
               
                   
                 Brain (fetal) 
                 11.1 
               
               
                   
                 Brain (whole) 
                 0.7 
               
               
                   
                 Brain (amygdala) 
                 1.1 
               
               
                   
                 Brain (cerebellum) 
                 0.3 
               
               
                   
                 Brain (hippocampus) 
                 1.5 
               
               
                   
                 Brain (substantia nigra) 
                 2.3 
               
               
                   
                 Brain (thalamus) 
                 2.4 
               
               
                   
                 Cerebral Cortex 
                 1.0 
               
               
                   
                 Spinal cord 
                 0.7 
               
               
                   
                 glio/astro U87-MG 
                 0.4 
               
               
                   
                 glio/astro U-118-MG 
                 0.4 
               
               
                   
                 astrocytoma SW1783 
                 0.4 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.7 
               
               
                   
                 astrocytoma SF-539 
                 0.3 
               
               
                   
                 astrocytoma SNB-75 
                 7.8 
               
               
                   
                 glioma SNB-19 
                 0.2 
               
               
                   
                 glioma U251 
                 1.2 
               
               
                   
                 glioma SF-295 
                 0.6 
               
               
                   
                 Heart (fetal) 
                 5.1 
               
               
                   
                 Heart 
                 0.7 
               
               
                   
                 Skeletal muscle (fetal) 
                 3.3 
               
               
                   
                 Skeletal muscle 
                 0.5 
               
               
                   
                 Bone marrow 
                 3.9 
               
               
                   
                 Thymus 
                 15.9 
               
               
                   
                 Spleen 
                 1.2 
               
               
                   
                 Lymph node 
                 4.6 
               
               
                   
                 Colorectal 
                 2.5 
               
               
                   
                 Stomach 
                 0.6 
               
               
                   
                 Small intestine 
                 1.8 
               
               
                   
                 Colon ca. SW480 
                 2.8 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 5.3 
               
               
                   
                 Colon ca. HT29 
                 0.3 
               
               
                   
                 Colon ca. HCT-116 
                 1.6 
               
               
                   
                 Colon ca. CaCo-2 
                 0.8 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 0.2 
               
               
                   
                 Colon ca. HCC-2998 
                 3.1 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 1.9 
               
               
                   
                 Bladder 
                 0.9 
               
               
                   
                 Trachea 
                 0.3 
               
               
                   
                 Kidney 
                 0.4 
               
               
                   
                 Kidney (fetal) 
                 4.9 
               
               
                   
                 Renal ca. 786-0 
                 0.3 
               
               
                   
                 Renal ca. A498 
                 1.9 
               
               
                   
                 Renal ca. RXF 393 
                 0.1 
               
               
                   
                 Renal ca. ACHN 
                 0.8 
               
               
                   
                 Renal ca. UO-31 
                 0.4 
               
               
                   
                 Renal ca. TK-10 
                 2.1 
               
               
                   
                 Liver 
                 0.2 
               
               
                   
                 Liver (fetal) 
                 1.4 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.7 
               
               
                   
                 Lung 
                 0.5 
               
               
                   
                 Lung (fetal) 
                 8.0 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 1.3 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 13.2 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 5.9 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 0.1 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.3 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 2.4 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 1.4 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 2.6 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 2.5 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 49.7 
               
               
                   
                 Mammary gland 
                 2.5 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.5 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.8 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.3 
               
               
                   
                 Breast ca. BT-549 
                 0.1 
               
               
                   
                 Breast ca. MDA-N 
                 100.0 
               
               
                   
                 Ovary 
                 1.3 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 2.6 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.1 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 2.7 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.1 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.6 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 1.3 
               
               
                   
                 Uterus 
                 1.4 
               
               
                   
                 Placenta 
                 0.2 
               
               
                   
                 Prostate 
                 0.5 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 0.0 
               
               
                   
                 Testis 
                 17.4 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 2.8 
               
               
                   
                 Melanoma M14 
                 79.6 
               
               
                   
                 Melanoma LOX IMVI 
                 2.1 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 9.9 
               
               
                   
                 Adipose 
                 1.9 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1282, Run 167614616    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BBD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 3.3 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 0.4 
               
               
                   
                 CC Margin (ODO3866) 
                 0.4 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 1.3 
               
               
                   
                 CC Margin (ODO3868) 
                 0.1 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 3.6 
               
               
                   
                 CC Margin (ODO3920) 
                 0.8 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 0.9 
               
               
                   
                 CC Margin (ODO3921) 
                 0.4 
               
               
                   
                 CC from Partial Hepatectomy (ODO4309) Mets 
                 0.9 
               
               
                   
                 Liver Margin (ODO4309) 
                 0.2 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 0.2 
               
               
                   
                 Lung Margin (OD04451-02) 
                 0.2 
               
               
                   
                 Normal Prostate 6546-1 
                 1.8 
               
               
                   
                 Prostate Cancer (OD04410) 
                 0.8 
               
               
                   
                 Prostate Margin (OD04410) 
                 1.1 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 0.7 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 1.6 
               
               
                   
                 Normal Lung 061010 
                 2.6 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 0.3 
               
               
                   
                 Muscle Margin (ODO4286) 
                 0.2 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 0.9 
               
               
                   
                 Lung Margin (OD03126) 
                 0.7 
               
               
                   
                 Lung Cancer (OD04404) 
                 0.5 
               
               
                   
                 Lung Margin (OD04404) 
                 0.6 
               
               
                   
                 Lung Cancer (OD04565) 
                 0.8 
               
               
                   
                 Lung Margin (OD04565) 
                 0.4 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 25.5 
               
               
                   
                 Lung Margin (OD04237-02) 
                 0.7 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 100.0 
               
               
                   
                 Liver Margin (ODO4310) 
                 0.4 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 21.8 
               
               
                   
                 Lung Margin (OD04321) 
                 0.5 
               
               
                   
                 Normal Kidney 
                 0.5 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 0.4 
               
               
                   
                 Kidney Margin (OD04338) 
                 0.7 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 0.2 
               
               
                   
                 Kidney Margin (OD04339) 
                 0.1 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 0.8 
               
               
                   
                 Kidney Margin (OD04340) 
                 0.6 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.5 
               
               
                   
                 Kidney Margin (OD04348) 
                 0.2 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 0.3 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 0.0 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.1 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 0.1 
               
               
                   
                 Kidney Cancer 8120607 
                 0.0 
               
               
                   
                 Kidney Margin 8120608 
                 0.0 
               
               
                   
                 Kidney Cancer 8120613 
                 0.1 
               
               
                   
                 Kidney Margin 8120614 
                 0.1 
               
               
                   
                 Kidney Cancer 9010320 
                 0.1 
               
               
                   
                 Kidney Margin 9010321 
                 0.1 
               
               
                   
                 Normal Uterus 
                 0.3 
               
               
                   
                 Uterus Cancer 064011 
                 2.5 
               
               
                   
                 Normal Thyroid 
                 0.4 
               
               
                   
                 Thyroid Cancer 064010 
                 0.3 
               
               
                   
                 Thyroid Cancer A302152 
                 0.2 
               
               
                   
                 Thyroid Margin A302153 
                 0.4 
               
               
                   
                 Normal Breast 
                 1.8 
               
               
                   
                 Breast Cancer (OD04566) 
                 1.6 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 0.7 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 2.3 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 0.7 
               
               
                   
                 Breast Cancer 064006 
                 0.8 
               
               
                   
                 Breast Cancer 1024 
                 1.2 
               
               
                   
                 Breast Cancer 9100266 
                 0.9 
               
               
                   
                 Breast Margin 9100265 
                 0.5 
               
               
                   
                 Breast Cancer A209073 
                 1.6 
               
               
                   
                 Breast Margin A209073 
                 1.5 
               
               
                   
                 Normal Liver 
                 0.1 
               
               
                   
                 Liver Cancer 064003 
                 0.3 
               
               
                   
                 Liver Cancer 1025 
                 0.1 
               
               
                   
                 Liver Cancer 1026 
                 0.1 
               
               
                   
                 Liver Cancer 6004-T 
                 0.0 
               
               
                   
                 Liver Tissue 6004-N 
                 0.9 
               
               
                   
                 Liver Cancer 6005-T 
                 0.3 
               
               
                   
                 Liver Tissue 6005-N 
                 0.0 
               
               
                   
                 Normal Bladder 
                 1.1 
               
               
                   
                 Bladder Cancer 1023 
                 0.2 
               
               
                   
                 Bladder Cancer A302173 
                 6.5 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 1.4 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 0.7 
               
               
                   
                 Normal Ovary 
                 0.8 
               
               
                   
                 Ovarian Cancer 064008 
                 2.9 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 3.8 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 0.2 
               
               
                   
                 Normal Stomach 
                 1.2 
               
               
                   
                 Gastric Cancer 9060358 
                 0.8 
               
               
                   
                 Stomach Margin 9060359 
                 0.7 
               
               
                   
                 Gastric Cancer 9060395 
                 0.8 
               
               
                   
                 Stomach Margin 9060394 
                 0.2 
               
               
                   
                 Gastric Cancer 9060397 
                 0.5 
               
               
                   
                 Stomach Margin 9060396 
                 0.2 
               
               
                   
                 Gastric Cancer 064005 
                 2.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1282, Run 170849610    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BBE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 12.0 
               
               
                   
                 Secondary Th2 act 
                 19.3 
               
               
                   
                 Secondary Tr1 act 
                 21.6 
               
               
                   
                 Secondary Th1 rest 
                 7.5 
               
               
                   
                 Secondary Th2 rest 
                 12.1 
               
               
                   
                 Secondary Tr1 rest 
                 9.6 
               
               
                   
                 Primary Th1 act 
                 20.0 
               
               
                   
                 Primary Th2 act 
                 19.6 
               
               
                   
                 Primary Tr1 act 
                 24.3 
               
               
                   
                 Primary Th1 rest 
                 23.8 
               
               
                   
                 Primary Th2 rest 
                 16.3 
               
               
                   
                 Primary Tr1 rest 
                 54.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 7.6 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 23.3 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 9.3 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 16.4 
               
               
                   
                 CD4 lymphocyte none 
                 3.6 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 23.7 
               
               
                   
                 LAK cells rest 
                 7.9 
               
               
                   
                 LAK cells IL-2 
                 26.8 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 5.5 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 10.8 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 14.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 1.5 
               
               
                   
                 NK Cells IL-2 rest 
                 29.1 
               
               
                   
                 Two Way MLR 3 day 
                 8.0 
               
               
                   
                 Two Way MLR 5 day 
                 7.0 
               
               
                   
                 Two Way MLR 7 day 
                 9.6 
               
               
                   
                 PBMC rest 
                 0.3 
               
               
                   
                 PBMC PWM 
                 4.0 
               
               
                   
                 PBMC PHA-L 
                 12.7 
               
               
                   
                 Ramos (B cell) none 
                 8.2 
               
               
                   
                 Ramos (B cell) ionomycin 
                 11.5 
               
               
                   
                 B lymphocytes PWM 
                 10.7 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 35.6 
               
               
                   
                 EOL-1 dbcAMP 
                 9.2 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 10.3 
               
               
                   
                 Dendritic cells none 
                 1.2 
               
               
                   
                 Dendritic cells LPS 
                 0.7 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.3 
               
               
                   
                 Monocytes rest 
                 1.1 
               
               
                   
                 Monocytes LPS 
                 2.4 
               
               
                   
                 Macrophages rest 
                 2.2 
               
               
                   
                 Macrophages LPS 
                 0.1 
               
               
                   
                 HUVEC none 
                 1.1 
               
               
                   
                 HUVEC starved 
                 3.6 
               
               
                   
                 HUVEC IL-1beta 
                 2.6 
               
               
                   
                 HUVEC IFN gamma 
                 2.6 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 1.4 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 3.1 
               
               
                   
                 HUVEC IL-11 
                 3.4 
               
               
                   
                 Lung Microvascular EC none 
                 6.4 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 9.5 
               
               
                   
                 Microvascular Dermal EC none 
                 10.4 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 10.2 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 3.4 
               
               
                   
                 Small airway epithelium none 
                 0.0 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 2.7 
               
               
                   
                 Coronery artery SMC rest 
                 0.3 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.1 
               
               
                   
                 Astrocytes rest 
                 1.1 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 2.4 
               
               
                   
                 KU-812 (Basophil) rest 
                 14.5 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 9.4 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 4.6 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 2.4 
               
               
                   
                 Liver cirrhosis 
                 2.2 
               
               
                   
                 NCI-H292 none 
                 10.6 
               
               
                   
                 NCI-H292 IL-4 
                 18.2 
               
               
                   
                 NCI-H292 IL-9 
                 24.5 
               
               
                   
                 NCI-H292 IL-13 
                 14.8 
               
               
                   
                 NCI-H292 IFN gamma 
                 11.1 
               
               
                   
                 HPAEC none 
                 3.3 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 5.3 
               
               
                   
                 Lung fibroblast none 
                 1.1 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.6 
               
               
                   
                 Lung fibroblast IL-4 
                 0.0 
               
               
                   
                 Lung fibroblast IL-9 
                 0.3 
               
               
                   
                 Lung fibroblast IL-13 
                 0.0 
               
               
                   
                 Lung fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 5.4 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 24.3 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 5.0 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 0.3 
               
               
                   
                 Dermal fibroblast IL-4 
                 1.6 
               
               
                   
                 Dermal Fibroblasts rest 
                 0.8 
               
               
                   
                 Neutrophils TNFa + LPS 
                 0.3 
               
               
                   
                 Neutrophils rest 
                 0.6 
               
               
                   
                 Colon 
                 8.4 
               
               
                   
                 Lung 
                 5.1 
               
               
                   
                 Thymus 
                 100.0 
               
               
                   
                 Kidney 
                 1.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1282, Run 169828985    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BBF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 5 Islet 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 97457_Patient-02go_adipose 
                 42.6 
               
               
                   
                 97476_Patient-07sk_skeletal muscle 
                 37.9 
               
               
                   
                 97477_Patient-07ut_uterus 
                 15.8 
               
               
                   
                 97478_Patient-07pl_placenta 
                 85.9 
               
               
                   
                 99167_Bayer Patient 1 
                 6.5 
               
               
                   
                 97482_Patient-08ut_uterus 
                 13.4 
               
               
                   
                 97483_Patient-08pl_placenta 
                 17.4 
               
               
                   
                 97486_Patient-09sk_skeletal muscle 
                 8.4 
               
               
                   
                 97487_Patient-09ut_uterus 
                 47.6 
               
               
                   
                 97488_Patient-09pl_placenta 
                 60.3 
               
               
                   
                 97492_Patient-10ut_uterus 
                 27.5 
               
               
                   
                 97493_Patient-10pl_placenta 
                 48.3 
               
               
                   
                 97495_Patient-11go_adipose 
                 27.5 
               
               
                   
                 97496_Patient-11sk_skeletal muscle 
                 2.9 
               
               
                   
                 97497_Patient-11ut_uterus 
                 29.7 
               
               
                   
                 97498_Patient-11pl_placenta 
                 11.8 
               
               
                   
                 97500_Patient-12go_adipose 
                 45.1 
               
               
                   
                 97501_Patient-12sk_skeletal muscle 
                 24.7 
               
               
                   
                 97502_Patient-12ut_uterus 
                 44.1 
               
               
                   
                 97503_Patient-12pl_placenta 
                 8.1 
               
               
                   
                 94721_Donor 2 U - A_Mesenchymal Stem Cells 
                 1.2 
               
               
                   
                 94722_Donor 2 U - B_Mesenchymal Stem Cells 
                 5.4 
               
               
                   
                 94723_Donor 2 U - C_Mesenchymal Stem Cells 
                 1.5 
               
               
                   
                 94709_Donor 2 AM - A_adipose 
                 11.9 
               
               
                   
                 94710_Donor 2 AM - B_adipose 
                 1.5 
               
               
                   
                 94711_Donor 2 AM - C_adipose 
                 1.5 
               
               
                   
                 94712_Donor 2 AD - A_adipose 
                 0.0 
               
               
                   
                 94713_Donor 2 AD - B_adipose 
                 1.5 
               
               
                   
                 94714_Donor 2 AD - C_adipose 
                 11.1 
               
               
                   
                 94742_Donor 3 U - A_Mesenchymal Stem Cells 
                 0.0 
               
               
                   
                 94743_Donor 3 U - B_Mesenchymal Stem Cells 
                 5.6 
               
               
                   
                 94730_Donor 3 AM - A_adipose 
                 0.0 
               
               
                   
                 94731_Donor 3 AM - B_adipose 
                 1.7 
               
               
                   
                 94732_Donor 3 AM - C_adipose 
                 3.9 
               
               
                   
                 94733_Donor 3 AD - A_adipose 
                 1.6 
               
               
                   
                 94734_Donor 3 AD - B_adipose 
                 1.8 
               
               
                   
                 94735_Donor 3 AD - C_adipose 
                 3.0 
               
               
                   
                 77138_Liver_HepG2untreated 
                 55.5 
               
               
                   
                 73556_Heart_Cardiac stromal cells (primary) 
                 85.3 
               
               
                   
                 81735_Small Intestine 
                 100.0 
               
               
                   
                 72409_Kidney_Proximal Convoluted Tubule 
                 23.7 
               
               
                   
                 82685_Small intestine_Duodenum 
                 31.4 
               
               
                   
                 90650_Adrenal_Adrenocortical adenoma 
                 0.0 
               
               
                   
                 72410_Kidney_HRCE 
                 22.8 
               
               
                   
                 72411_Kidney_HRE 
                 27.5 
               
               
                   
                 73139_Uterus_Uterine smooth muscle cells 
                 3.6 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1282, Run 255155568    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BBG 
               
             
            
               
                   
               
               
                   
               
               
                 general oncology screening panel_v_2.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Colon cancer 1 
                 7.9 
               
               
                   
                 Colon NAT 1 
                 3.5 
               
               
                   
                 Colon cancer 2 
                 4.9 
               
               
                   
                 Colon NAT 2 
                 2.1 
               
               
                   
                 Colon cancer 3 
                 1.5 
               
               
                   
                 Colon NAT 3 
                 3.8 
               
               
                   
                 Colon malignant cancer 4 
                 18.7 
               
               
                   
                 Colon NAT 4 
                 4.0 
               
               
                   
                 Lung cancer 1 
                 7.1 
               
               
                   
                 Lung NAT 1 
                 2.5 
               
               
                   
                 Lung cancer 2 
                 100.0 
               
               
                   
                 Lung NAT 2 
                 1.6 
               
               
                   
                 Squamous cell carcinoma 3 
                 33.2 
               
               
                   
                 Lung NAT 3 
                 1.2 
               
               
                   
                 Metastatic melanoma 1 
                 22.8 
               
               
                   
                 Melanoma 2 
                 2.0 
               
               
                   
                 Melanoma 3 
                 5.7 
               
               
                   
                 Metastatic melanoma 4 
                 34.4 
               
               
                   
                 Metastatic melanoma 5 
                 62.9 
               
               
                   
                 Bladder cancer 1 
                 2.0 
               
               
                   
                 Bladder NAT 1 
                 0.0 
               
               
                   
                 Bladder cancer 2 
                 6.0 
               
               
                   
                 Bladder NAT 2 
                 1.2 
               
               
                   
                 Bladder NAT 3 
                 0.5 
               
               
                   
                 Bladder NAT 4 
                 8.1 
               
               
                   
                 Prostate adenocarcinoma 1 
                 56.6 
               
               
                   
                 Prostate adenocarcinoma 2 
                 2.1 
               
               
                   
                 Prostate adenocarcinoma 3 
                 4.3 
               
               
                   
                 Prostate adenocarcinoma 4 
                 4.1 
               
               
                   
                 Prostate NAT 5 
                 2.0 
               
               
                   
                 Prostate adenocarcinoma 6 
                 2.2 
               
               
                   
                 Prostate adenocarcinoma 7 
                 4.8 
               
               
                   
                 Prostate adenocarcinoma 8 
                 0.7 
               
               
                   
                 Prostate adenocarcinoma 9 
                 21.8 
               
               
                   
                 Prostate NAT 10 
                 0.8 
               
               
                   
                 Kidney cancer 1 
                 15.0 
               
               
                   
                 Kidney NAT 1 
                 3.1 
               
               
                   
                 Kidney cancer 2 
                 49.0 
               
               
                   
                 Kidney NAT 2 
                 2.9 
               
               
                   
                 Kidney cancer 3 
                 11.0 
               
               
                   
                 Kidney NAT 3 
                 1.9 
               
               
                   
                 Kidney cancer 4 
                 5.6 
               
               
                   
                 Kidney NAT 4 
                 0.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1282, Run 267211473    
               
            
           
         
       
     
      General_screening_panel_v1.4 Summary: Ag1282 Highest expression of this gene was seen in a melanoma cell line. In addition, significantly higher levels of expression were seen in a breast cancer cell line. Thus, expression of this is useful as a marker to differentiate between these samples and other samples on this panel and as a marker to detect the presence of melanoma and breast cancer. Furthermore, therapeutic modulation of the expression or function of this gene or gene product is effective in the treatment of melanoma and breast cancers.  
      Among tissues with metabolic function, this gene was expressed at moderate levels in pituitary, adipose, adrenal gland, pancreas, thyroid, and adult and fetal skeletal muscle, heart, and liver. This widespread expression among these tissues shows that this gene product plays a role in normal neuroendocrine and metabolic function and that disregulated expression of this gene contributes to neuroendocrine disorders or metabolic diseases, such as obesity and diabetes.  
      In addition, this gene was expressed at much higher levels in fetal lung, liver and skeletal muscle tissue (CTs=27-29) when compared to expression in the adult counterpart (CTs=30-32). Thus, expression of this gene is useful as a marker to differentiate between the fetal and adult source of these tissue.  
      This molecule is a novel ovostatin that was also expressed at moderate levels in the all regions of the CNS examined. This gene or gene product is a target for the treatment of neurologic diseases.  
      HASS Panel v1.0 Summary: High levels of expression were detected in samples derived from a glioblastoma and a medulloblastoma.  
      Panel 1.3D Summary: Ag1282 Expression of this gene was consistent with expression in Panel 1.4. The expression of this gene was highest in a sample derived from a breast cancer cell line (MDA-N) (CT=26.9). In addition, there was expression in other samples derived from lung cancer cell lines and melanoma cell lines. Thus, the expression of this gene is useful as a marker to distinguish MDA-N cells from other samples in the panel. This gene encodes a novel ovostatin. Ovostatins are protease inhibitors that have been shown to support the growth of tumor cells in the absence of serum. They have also been shown to mediate accelerated fibroblast growth, collagen deposition and capillary formation. Thus, therapeutic targeting of this gene product is useful for blocking the uncontrolled growth of cancer cells related to the action of this gene, especially in those cancer types like lung, breast and melanoma tumors where the gene is overexpressed in the tumor compared to the normal adjacent tissue.  
      Panel 2D Summary: Ag1282 Highest expression of this gene was seen in a sample derived from an ocular melanoma metastasis to the liver (CT=27). In addition, there was expression in other samples derived from lung cancers. Thus, expression of this gene is useful as a marker to distinguish liver cancer cells from other samples in the panel. Moreover, therapeutic modulation of this gene, through the use of small molecule drugs, protein therapeutics or antibodies is of benefit in the treatment of liver or lung cancer.  
      Panel 4.1D Summary: Ag1282 This gene, an ovostatin-like protein, is related to ovostatin, a known inhibitor of proteinases of all four mechanistic classes, (serine proteinases, cysteine proteinases, aspartyl proteinases, and metalloproteinases) (Saxena I, Cell Mol Life Sci 1997 January;53(1):13-23; Ofuji Y, Periodontal Clin Investig 1992 Fall;14(2):13-22). Highest expression of the gene was seen in the thymus and kidney (CTs=28-29). In addition, moderate to low levels of expression were seen in most of the samples on this panel. This gene or its protein product is useful as a therapeutic protein for the reduction of various proteolytic activities involved in inflammatory and autoimmune diseases such as, but not limited to, Crohn&#39;s disease, ulcerative colitis, multiple sclerosis, chronic obstructive pulmonary disease, asthma, emphysema, rheumatoid arthritis, lupus erythematosus, or psoriasis, wound healing, and infection.  
      Panel 5 Islet Summary: Ag1282 Highest expression of this gene was seen in the small intestine (CT=28), with moderate to low levels of expression seen in metabolic tissues, including adipose, placenta, and skeletal muscle. Thus, targeting this gene or its protein product is useful in the treatment of metabolic disease, including obesity and type II diabetes.  
      general oncology screening panel_v — 2.4 Summary: Ag1282 Highest expression of this gene was seen in a lung cancer sample (CT=28). In addition, this gene was more highly expressed in lung and kidney cancer than in the corresponding normal adjacent tissue. Thus, therapeutic modulation of the expression or function of this gene product is useful in the treatment of lung and kidney cancer.  
      BC. CG59841-01: Novel Human Agrin  
      Expression of gene CG59841-01 was assessed using the primer-probe set Ag3605, described in Table BCA. Results of the RTQ-PCR runs are shown in Tables BCB, BCC, BCD and BCE.  
               TABLE BCA                          Probe Name Ag3605                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-gaccccaagtcagaactgttc-3′   21   3174   1549                   Probe   TET-5′-attgagagcaccctggacgacctctt-3′-   26   3213   1550           TAMRA               Reverse   5′-gaaatccttcttgacgtctgaa-3′   22   3245   1551                  
 
     
       
         
           
               
             
               
                 TABLE BCB 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 1.4 
               
               
                   
                 Melanoma* Hs688(A).T 
                 2.6 
               
               
                   
                 Melanoma* Hs688(B).T 
                 4.6 
               
               
                   
                 Melanoma* M14 
                 6.7 
               
               
                   
                 Melanoma* LOXIMVI 
                 4.8 
               
               
                   
                 Melanoma* SK-MEL-5 
                 2.6 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 9.0 
               
               
                   
                 Testis Pool 
                 1.3 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 21.0 
               
               
                   
                 Prostate Pool 
                 0.9 
               
               
                   
                 Placenta 
                 0.9 
               
               
                   
                 Uterus Pool 
                 0.4 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 77.4 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 42.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 9.5 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 39.2 
               
               
                   
                 Ovarian ca. IGROV-1 
                 22.1 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 18.0 
               
               
                   
                 Ovary 
                 1.5 
               
               
                   
                 Breast ca. MCF-7 
                 7.7 
               
               
                   
                 Breast ca. MDA-MB-231 
                 22.7 
               
               
                   
                 Breast ca. BT 549 
                 13.2 
               
               
                   
                 Breast ca. T47D 
                 100.0 
               
               
                   
                 Breast ca. MDA-N 
                 4.8 
               
               
                   
                 Breast Pool 
                 1.6 
               
               
                   
                 Trachea 
                 2.8 
               
               
                   
                 Lung 
                 0.2 
               
               
                   
                 Fetal Lung 
                 11.4 
               
               
                   
                 Lung ca. NCI-N417 
                 1.4 
               
               
                   
                 Lung ca. LX-1 
                 10.5 
               
               
                   
                 Lung ca. NCI-H146 
                 0.1 
               
               
                   
                 Lung ca. SHP-77 
                 1.1 
               
               
                   
                 Lung ca. A549 
                 15.6 
               
               
                   
                 Lung ca. NCI-H526 
                 5.4 
               
               
                   
                 Lung ca. NCI-H23 
                 18.9 
               
               
                   
                 Lung ca. NCI-H460 
                 11.5 
               
               
                   
                 Lung ca. HOP-62 
                 23.7 
               
               
                   
                 Lung ca. NCI-H522 
                 1.8 
               
               
                   
                 Liver 
                 0.5 
               
               
                   
                 Fetal Liver 
                 0.8 
               
               
                   
                 Liver ca. HepG2 
                 15.5 
               
               
                   
                 Kidney Pool 
                 1.5 
               
               
                   
                 Fetal Kidney 
                 5.8 
               
               
                   
                 Renal ca. 786-0 
                 46.3 
               
               
                   
                 Renal ca. A498 
                 13.8 
               
               
                   
                 Renal ca. ACHN 
                 14.3 
               
               
                   
                 Renal ca. UO-31 
                 41.5 
               
               
                   
                 Renal ca. TK-10 
                 19.3 
               
               
                   
                 Bladder 
                 8.4 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 87.7 
               
               
                   
                 Gastric ca. KATO III 
                 17.8 
               
               
                   
                 Colon ca. SW-948 
                 9.2 
               
               
                   
                 Colon ca. SW480 
                 25.0 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 5.0 
               
               
                   
                 Colon ca. HT29 
                 26.8 
               
               
                   
                 Colon ca. HCT-116 
                 4.9 
               
               
                   
                 Colon ca. CaCo-2 
                 13.6 
               
               
                   
                 Colon cancer tissue 
                 10.2 
               
               
                   
                 Colon ca. SW1116 
                 5.1 
               
               
                   
                 Colon ca. Colo-205 
                 1.8 
               
               
                   
                 Colon ca. SW-48 
                 1.2 
               
               
                   
                 Colon Pool 
                 1.9 
               
               
                   
                 Small Intestine Pool 
                 0.6 
               
               
                   
                 Stomach Pool 
                 1.5 
               
               
                   
                 Bone Marrow Pool 
                 0.6 
               
               
                   
                 Fetal Heart 
                 1.4 
               
               
                   
                 Heart Pool 
                 0.7 
               
               
                   
                 Lymph Node Pool 
                 2.1 
               
               
                   
                 Fetal Skeletal Muscle 
                 0.9 
               
               
                   
                 Skeletal Muscle Pool 
                 0.4 
               
               
                   
                 Spleen Pool 
                 0.7 
               
               
                   
                 Thymus Pool 
                 1.8 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 5.9 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 11.7 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 1.2 
               
               
                   
                 CNS cancer (astro) SF-539 
                 6.7 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 22.8 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 25.0 
               
               
                   
                 CNS cancer (glio) SF-295 
                 35.1 
               
               
                   
                 Brain (Amygdala) Pool 
                 1.7 
               
               
                   
                 Brain (cerebellum) 
                 1.4 
               
               
                   
                 Brain (fetal) 
                 7.0 
               
               
                   
                 Brain (Hippocampus) Pool 
                 1.6 
               
               
                   
                 Cerebral Cortex Pool 
                 1.9 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 2.8 
               
               
                   
                 Brain (Thalamus) Pool 
                 2.7 
               
               
                   
                 Brain (whole) 
                 3.4 
               
               
                   
                 Spinal Cord Pool 
                 1.8 
               
               
                   
                 Adrenal Gland 
                 0.2 
               
               
                   
                 Pituitary gland Pool 
                 0.3 
               
               
                   
                 Salivary Gland 
                 1.1 
               
               
                   
                 Thyroid (female) 
                 3.3 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 23.7 
               
               
                   
                 Pancreas Pool 
                 3.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3605, Run 213406184    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BCC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2.2 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 4.7 
               
               
                   
                 Colon cancer (OD06064) 
                 6.3 
               
               
                   
                 Colon Margin (OD06064) 
                 2.3 
               
               
                   
                 Colon cancer (OD06159) 
                 2.1 
               
               
                   
                 Colon Margin (OD06159) 
                 1.8 
               
               
                   
                 Colon cancer (OD06297-04) 
                 2.0 
               
               
                   
                 Colon Margin (OD06297-05) 
                 3.0 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 3.6 
               
               
                   
                 CC Margin (ODO3921) 
                 1.3 
               
               
                   
                 Colon cancer metastasis (OD06104) 
                 1.1 
               
               
                   
                 Lung Margin (OD06104) 
                 1.0 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 4.5 
               
               
                   
                 Lung Margin (OD04451-02) 
                 6.7 
               
               
                   
                 Normal Prostate 
                 2.1 
               
               
                   
                 Prostate Cancer (OD04410) 
                 3.9 
               
               
                   
                 Prostate Margin (OD04410) 
                 3.4 
               
               
                   
                 Normal Ovary 
                 7.6 
               
               
                   
                 Ovarian cancer (OD06283-03) 
                 27.9 
               
               
                   
                 Ovarian Margin (OD06283-07) 
                 2.0 
               
               
                   
                 Ovarian Cancer 064008 
                 16.0 
               
               
                   
                 Ovarian cancer (OD06145) 
                 10.1 
               
               
                   
                 Ovarian Margin (OD06145) 
                 8.2 
               
               
                   
                 Ovarian cancer (OD06455-03) 
                 28.9 
               
               
                   
                 Ovarian Margin (OD06455-07) 
                 1.9 
               
               
                   
                 Normal Lung 
                 2.9 
               
               
                   
                 Invasive poor diff. lung adeno (ODO4945-01 
                 9.4 
               
               
                   
                 Lung Margin (ODO4945-03) 
                 7.9 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 7.5 
               
               
                   
                 Lung Margin (OD03126) 
                 7.0 
               
               
                   
                 Lung Cancer (OD05014A) 
                 17.0 
               
               
                   
                 Lung Margin (OD05014B) 
                 11.7 
               
               
                   
                 Lung cancer (OD06081) 
                 12.2 
               
               
                   
                 Lung Margin (OD06081) 
                 2.4 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 1.8 
               
               
                   
                 Lung Margin (OD04237-02) 
                 16.2 
               
               
                   
                 Ocular Melanoma Metastasis 
                 8.4 
               
               
                   
                 Ocular Melanoma Margin (Liver) 
                 2.9 
               
               
                   
                 Melanoma Metastasis 
                 4.0 
               
               
                   
                 Melanoma Margin (Lung) 
                 3.8 
               
               
                   
                 Normal Kidney 
                 10.9 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 35.4 
               
               
                   
                 Kidney Margin (OD04338) 
                 20.4 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 52.9 
               
               
                   
                 Kidney Margin (OD04339) 
                 16.6 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 16.6 
               
               
                   
                 Kidney Margin (OD04340) 
                 7.4 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 11.2 
               
               
                   
                 Kidney Margin (OD04348) 
                 100.0 
               
               
                   
                 Kidney malignant cancer (OD06204B) 
                 21.6 
               
               
                   
                 Kidney normal adjacent tissue (OD06204E) 
                 23.2 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 53.2 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 21.3 
               
               
                   
                 Kidney Cancer 8120613 
                 1.1 
               
               
                   
                 Kidney Margin 8120614 
                 14.1 
               
               
                   
                 Kidney Cancer 9010320 
                 20.3 
               
               
                   
                 Kidney Margin 9010321 
                 15.0 
               
               
                   
                 Kidney Cancer 8120607 
                 71.7 
               
               
                   
                 Kidney Margin 8120608 
                 12.2 
               
               
                   
                 Normal Uterus 
                 7.3 
               
               
                   
                 Uterine Cancer 064011 
                 6.9 
               
               
                   
                 Normal Thyroid 
                 4.3 
               
               
                   
                 Thyroid Cancer 064010 
                 27.0 
               
               
                   
                 Thyroid Cancer A302152 
                 19.1 
               
               
                   
                 Thyroid Margin A302153 
                 8.1 
               
               
                   
                 Normal Breast 
                 14.0 
               
               
                   
                 Breast Cancer (OD04566) 
                 13.4 
               
               
                   
                 Breast Cancer 1024 
                 35.1 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 31.6 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 8.7 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 13.3 
               
               
                   
                 Breast Cancer 064006 
                 21.5 
               
               
                   
                 Breast Cancer 9100266 
                 17.7 
               
               
                   
                 Breast Margin 9100265 
                 16.5 
               
               
                   
                 Breast Cancer A209073 
                 13.2 
               
               
                   
                 Breast Margin A2090734 
                 35.4 
               
               
                   
                 Breast cancer (OD06083) 
                 24.5 
               
               
                   
                 Breast cancer node metastasis (OD06083) 
                 21.5 
               
               
                   
                 Normal Liver 
                 5.0 
               
               
                   
                 Liver Cancer 1026 
                 15.5 
               
               
                   
                 Liver Cancer 1025 
                 12.2 
               
               
                   
                 Liver Cancer 6004-T 
                 7.8 
               
               
                   
                 Liver Tissue 6004-N 
                 6.1 
               
               
                   
                 Liver Cancer 6005-T 
                 25.0 
               
               
                   
                 Liver Tissue 6005-N 
                 12.4 
               
               
                   
                 Liver Cancer 064003 
                 12.9 
               
               
                   
                 Normal Bladder 
                 14.2 
               
               
                   
                 Bladder Cancer 1023 
                 9.5 
               
               
                   
                 Bladder Cancer A302173 
                 12.2 
               
               
                   
                 Normal Stomach 
                 8.7 
               
               
                   
                 Gastric Cancer 9060397 
                 8.9 
               
               
                   
                 Stomach Margin 9060396 
                 7.4 
               
               
                   
                 Gastric Cancer 9060395 
                 7.0 
               
               
                   
                 Stomach Margin 9060394 
                 7.5 
               
               
                   
                 Gastric Cancer 064005 
                 6.9 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3605, Run 173764229    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BCD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 1.0 
               
               
                   
                 Secondary Th2 act 
                 5.1 
               
               
                   
                 Secondary Tr1 act 
                 2.5 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.4 
               
               
                   
                 Secondary Tr1 rest 
                 0.4 
               
               
                   
                 Primary Th1 act 
                 3.6 
               
               
                   
                 Primary Th2 act 
                 1.1 
               
               
                   
                 Primary Tr1 act 
                 3.4 
               
               
                   
                 Primary Th1 rest 
                 0.9 
               
               
                   
                 Primary Th2 rest 
                 0.5 
               
               
                   
                 Primary Tr1 rest 
                 0.2 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 43.5 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 5.0 
               
               
                   
                 CD8 lymphocyte act 
                 3.9 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 3.7 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 3.3 
               
               
                   
                 CD4 lymphocyte none 
                 0.3 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.3 
               
               
                   
                 LAK cells rest 
                 5.0 
               
               
                   
                 LAK cells IL-2 
                 2.8 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 1.4 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 2.3 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 2.9 
               
               
                   
                 LAK cells PMA/ionomycin 
                 6.8 
               
               
                   
                 NK Cells IL-2 rest 
                 1.6 
               
               
                   
                 Two Way MLR 3 day 
                 10.7 
               
               
                   
                 Two Way MLR 5 day 
                 6.5 
               
               
                   
                 Two Way MLR 7 day 
                 4.3 
               
               
                   
                 PBMC rest 
                 0.0 
               
               
                   
                 PBMC PWM 
                 5.0 
               
               
                   
                 PBMC PHA-L 
                 5.5 
               
               
                   
                 Ramos (B cell) none 
                 0.4 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.2 
               
               
                   
                 B lymphocytes PWM 
                 2.4 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 1.5 
               
               
                   
                 EOL-1 dbcAMP 
                 3.4 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 18.3 
               
               
                   
                 Dendritic cells none 
                 14.8 
               
               
                   
                 Dendritic cells LPS 
                 48.3 
               
               
                   
                 Dendritic cells anti-CD40 
                 9.7 
               
               
                   
                 Monocytes rest 
                 0.9 
               
               
                   
                 Monocytes LPS 
                 66.4 
               
               
                   
                 Macrophages rest 
                 16.2 
               
               
                   
                 Macrophages LPS 
                 54.7 
               
               
                   
                 HUVEC none 
                 9.3 
               
               
                   
                 HUVEC starved 
                 14.4 
               
               
                   
                 HUVEC IL-1beta 
                 15.6 
               
               
                   
                 HUVEC IFN gamma 
                 12.9 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 37.6 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 31.4 
               
               
                   
                 HUVEC IL-11 
                 14.9 
               
               
                   
                 Lung Microvascular EC none 
                 79.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 100.0 
               
               
                   
                 Microvascular Dermal EC none 
                 49.7 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 56.6 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 78.5 
               
               
                   
                 Small airway epithelium none 
                 31.0 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 81.8 
               
               
                   
                 Coronery artery SMC rest 
                 17.2 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 22.2 
               
               
                   
                 Astrocytes rest 
                 80.1 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 82.9 
               
               
                   
                 KU-812 (Basophil) rest 
                 2.6 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.6 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 70.7 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 77.4 
               
               
                   
                 Liver cirrhosis 
                 13.2 
               
               
                   
                 NCI-H292 none 
                 57.8 
               
               
                   
                 NCI-H292 IL-4 
                 62.4 
               
               
                   
                 NCI-H292 IL-9 
                 61.6 
               
               
                   
                 NCI-H292 IL-13 
                 53.6 
               
               
                   
                 NCI-H292 IFN gamma 
                 67.4 
               
               
                   
                 HPAEC none 
                 21.5 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 37.6 
               
               
                   
                 Lung fibroblast none 
                 22.4 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 71.2 
               
               
                   
                 Lung fibroblast IL-4 
                 16.2 
               
               
                   
                 Lung fibroblast IL-9 
                 31.9 
               
               
                   
                 Lung fibroblast IL-13 
                 18.7 
               
               
                   
                 Lung fibroblast IFN gamma 
                 23.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 15.9 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 15.9 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 17.2 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 7.2 
               
               
                   
                 Dermal fibroblast IL-4 
                 7.2 
               
               
                   
                 Dermal Fibroblasts rest 
                 4.3 
               
               
                   
                 Neutrophils TNFa + LPS 
                 0.0 
               
               
                   
                 Neutrophils rest 
                 0.2 
               
               
                   
                 Colon 
                 7.0 
               
               
                   
                 Lung 
                 23.3 
               
               
                   
                 Thymus 
                 5.8 
               
               
                   
                 Kidney 
                 23.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3605, Run 169943454    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BCE 
               
             
            
               
                   
               
               
                   
               
               
                 general oncology screening panel_v_2.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Colon cancer 1 
                 11.6 
               
               
                   
                 Colon cancer NAT 1 
                 5.3 
               
               
                   
                 Colon cancer 2 
                 18.6 
               
               
                   
                 Colon cancer NAT 2 
                 3.2 
               
               
                   
                 Colon cancer 3 
                 22.2 
               
               
                   
                 Colon cancer NAT 3 
                 7.7 
               
               
                   
                 Colon malignant cancer 4 
                 23.5 
               
               
                   
                 Colon normal adjacent tissue 4 
                 2.0 
               
               
                   
                 Lung cancer 1 
                 57.0 
               
               
                   
                 Lung NAT 1 
                 3.1 
               
               
                   
                 Lung cancer 2 
                 100.0 
               
               
                   
                 Lung NAT 2 
                 3.9 
               
               
                   
                 Squamous cell carcinoma 3 
                 41.2 
               
               
                   
                 Lung NAT 3 
                 1.7 
               
               
                   
                 metastatic melanoma 1 
                 5.4 
               
               
                   
                 Melanoma 2 
                 3.2 
               
               
                   
                 Melanoma 3 
                 3.7 
               
               
                   
                 metastatic melanoma 4 
                 12.5 
               
               
                   
                 metastatic melanoma 5 
                 7.9 
               
               
                   
                 Bladder cancer 1 
                 0.5 
               
               
                   
                 Bladder cancer NAT 1 
                 0.0 
               
               
                   
                 Bladder cancer 2 
                 6.0 
               
               
                   
                 Bladder cancer NAT 2 
                 0.2 
               
               
                   
                 Bladder cancer NAT 3 
                 1.7 
               
               
                   
                 Bladder cancer NAT 4 
                 1.8 
               
               
                   
                 Prostate adenocarcinoma 1 
                 2.4 
               
               
                   
                 Prostate adenocarcinoma 2 
                 2.6 
               
               
                   
                 Prostate adenocarcinoma 3 
                 5.2 
               
               
                   
                 Prostate adenocarcinoma 4 
                 21.9 
               
               
                   
                 Prostate cancer NAT 5 
                 5.4 
               
               
                   
                 Prostate adenocarcinoma 6 
                 4.4 
               
               
                   
                 Prostate adenocarcinoma 7 
                 3.8 
               
               
                   
                 Prostate adenocarcinoma 8 
                 1.8 
               
               
                   
                 Prostate adenocarcinoma 9 
                 10.7 
               
               
                   
                 Prostate cancer NAT 10 
                 0.7 
               
               
                   
                 Kidney cancer 1 
                 38.7 
               
               
                   
                 Kidney NAT 1 
                 20.6 
               
               
                   
                 Kidney cancer 2 
                 66.4 
               
               
                   
                 Kidney NAT 2 
                 39.8 
               
               
                   
                 Kidney cancer 3 
                 64.6 
               
               
                   
                 Kidney NAT 3 
                 19.6 
               
               
                   
                 Kidney cancer 4 
                 16.4 
               
               
                   
                 Kidney NAT 4 
                 15.6 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3605, Run 260268655    
               
            
           
         
       
     
      General_screening_panel_v1.4 Summary: Ag3605 Expression of this gene was highest in a breast cancer cell line (CT=25.2). Expression of this gene was primarily associated with cancer cell lines rather than with normal tissues and was upregulated in pancreatic, CNS, colon, gastric, renal, lung, breast, ovarian, and prostate cancer cell lines when compared to their respective normal tissues. Thus, therapeutic modulation of the activity of this gene or its protein product, using small molecule drugs, antibodies or protein therapeutics, is of benefit in the treatment of these types of cancers.  
      In addition, this gene was expressed at moderate levels in all regions of the central nervous system examined, including amygdala, hippocampus, substantia nigra, thalamus, cerebellum, cerebral cortex, and spinal cord. This gene encodes a protein with homology to agrin, a neuronal aggregating factor that induces the aggregation of acetylcholine receptors and other postsynaptic proteins on muscle fibers and is crucial for the formation of the neuromuscular junction. Arin plays an important role in defining neuronal responses to excitatory neurotransmitters both in vitro and in vivo (Hilgenberg LG, Mol Cell Neurosci 2002 January;19(1):97-110; Bixby J L,. J Neurobiol 2002 February 5;50(2):164-79). This gene expression in the central nervous system was consistent with the hypothesis that this protein functions as agrin. Therefore, this gene plays a role in central nervous system disorders such as Alzheimer&#39;s disease, Parkinson&#39;s disease, epilepsy, multiple sclerosis, schizophrenia and depression.  
      Among tissues with metabolic or endocrine function, this gene was expressed at moderate levels in pancreas, adipose, thyroid, and the gastrointestinal tract and at low levels in adrenal gland, pituitary gland, skeletal muscle, heart, and liver. Therefore, therapeutic modulation of the activity of this gene is useful in the treatment of endocrine/metabolically related diseases, such as obesity and diabetes.  
      Panel 2.2 Summary: Ag3605 Expression of this gene was highest in a sample of normal kidney (CT=27.4). In addition, expression of this gene was upregulated in a number of ovarian and renal cancers when compared to the matched control margins. Expression of this gene is useful as a marker for ovarian and renal carcinoma. Therapeutic modulation of the activity of this gene or its protein product, using small molecule drugs, antibodies or protein therapeutics, is of benefit in the treatment of renal and ovarian cancer.  
      Panel 4.1D Summary: Ag3605 Expression of this gene was highest in lung microvascular endothelial cells, microvascular dermal endothelial cells, mucoepidermoid cell line NCI-H292, astrocytes, and keratinocytes. Therefore, small molecule drug, antibody or protein therapeutics designed against the protein encoded by this gene is useful for the reduction or inhibition of inflammation in asthma, emphysema, allergy, psoriasis, muscular dystrophy and multiple sclerosis.  
      general oncology screening panel_V — 2.4 Summary: Ag3605 Highest expression of this gene was seen in lung cancer (CT=26.8). Higher levels of expression were seen in lung and kidney cancers when compared to expression in normal adjacent tissue. Expression of this gene is useful as a marker of lung and kidney cancers. Therapeutic modulation of the expression or function of this gene product is useful in the treatment of lung and kidney cancers.  
      BD. CG59905-01 and CG59905-02: Sushi Containing Membrane Protein  
      Expression of gene CG59905-01 and variant CG59905-02 was assessed using the primer-probe set Ag2443, described in Table BDA. Results of the RTQ-PCR runs are  
               TABLE BDA                          Probe Name Ag2443                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-cagtttgggaccgacttca-3′   19   652   1552                   Probe   TET-5′-caagactgtgagctatcagtgtaaccca-3′-   28   678   1553           TAMRA               Reverse   5′-tgactgcttccatgacatagc-3′   21   707   1554                  
 
     
       
         
           
               
             
               
                 TABLE BDB 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 16.6 
               
               
                   
                 Pancreas 1 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
               
               
                   
                 Adrenal gland 
                 1.5 
               
               
                   
                 Thyroid 
                 0.0 
               
               
                   
                 Salivary gland 
                 0.0 
               
               
                   
                 Pituitary gland 
                 2.2 
               
               
                   
                 Brain (fetal) 
                 51.4 
               
               
                   
                 Brain (whole) 
                 92.0 
               
               
                   
                 Brain (amygdala) 
                 52.1 
               
               
                   
                 Brain (cerebellum) 
                 47.6 
               
               
                   
                 Brain (hippocampus) 
                 78.5 
               
               
                   
                 Brain (substantia nigra) 
                 8.0 
               
               
                   
                 Brain (thalamus) 
                 12.9 
               
               
                   
                 Cerebral Cortex 
                 100.0 
               
               
                   
                 Spinal cord 
                 6.5 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.0 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.0 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 0.0 
               
               
                   
                 glioma SNB-19 
                 0.6 
               
               
                   
                 glioma U251 
                 29.9 
               
               
                   
                 glioma SF-295 
                 1.9 
               
               
                   
                 Heart (fetal) 
                 0.0 
               
               
                   
                 Heart 
                 0.0 
               
               
                   
                 Skeletal muscle (fetal) 
                 6.2 
               
               
                   
                 Skeletal muscle 
                 0.8 
               
               
                   
                 Bone marrow 
                 0.0 
               
               
                   
                 Thymus 
                 0.0 
               
               
                   
                 Spleen 
                 5.4 
               
               
                   
                 Lymph node 
                 0.5 
               
               
                   
                 Colorectal 
                 0.7 
               
               
                   
                 Stomach 
                 0.0 
               
               
                   
                 Small intestine 
                 1.5 
               
               
                   
                 Colon ca. SW480 
                 0.0 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 0.0 
               
               
                   
                 Colon ca. HCC-2998 
                 0.0 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.0 
               
               
                   
                 Bladder 
                 1.2 
               
               
                   
                 Trachea 
                 2.0 
               
               
                   
                 Kidney 
                 4.1 
               
               
                   
                 Kidney (fetal) 
                 2.5 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Liver (fetal) 
                 0.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
               
               
                   
                 Lung 
                 0.0 
               
               
                   
                 Lung (fetal) 
                 1.4 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.0 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 16.8 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 1.6 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 11.2 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 4.8 
               
               
                   
                 Mammary gland 
                 2.1 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 10.9 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 9.3 
               
               
                   
                 Ovary 
                 1.1 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 11.5 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 0.8 
               
               
                   
                 Uterus 
                 2.8 
               
               
                   
                 Placenta 
                 2.9 
               
               
                   
                 Prostate 
                 0.9 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 0.0 
               
               
                   
                 Testis 
                 20.9 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.6 
               
               
                   
                 Melanoma UACC-62 
                 19.5 
               
               
                   
                 Melanoma M14 
                 15.1 
               
               
                   
                 Melanoma LOX IMVI 
                 0.7 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 7.3 
               
               
                   
                 Adipose 
                 0.4 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2443, Run 165517738    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BDC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 12.6 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 1.2 
               
               
                   
                 CC Margin (ODO3866) 
                 2.9 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 1.9 
               
               
                   
                 CC Margin (ODO3868) 
                 3.2 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 1.5 
               
               
                   
                 CC Margin (ODO3920) 
                 2.6 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 9.3 
               
               
                   
                 CC Margin (ODO3921) 
                 2.9 
               
               
                   
                 CC from Partial Hepatectomy (ODO4309) Mets 
                 0.0 
               
               
                   
                 Liver Margin (ODO4309) 
                 0.0 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 2.5 
               
               
                   
                 Lung Margin (OD04451-02) 
                 18.0 
               
               
                   
                 Normal Prostate 6546-1 
                 4.2 
               
               
                   
                 Prostate Cancer (OD04410) 
                 0.0 
               
               
                   
                 Prostate Margin (OD04410) 
                 5.3 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 6.0 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 4.5 
               
               
                   
                 Normal Lung 061010 
                 29.9 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 2.4 
               
               
                   
                 Muscle Margin (ODO4286) 
                 3.1 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 12.2 
               
               
                   
                 Lung Margin (OD03126) 
                 20.4 
               
               
                   
                 Lung Cancer (OD04404) 
                 3.0 
               
               
                   
                 Lung Margin (OD04404) 
                 30.1 
               
               
                   
                 Lung Cancer (OD04565) 
                 0.8 
               
               
                   
                 Lung Margin (OD04565) 
                 9.0 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 7.8 
               
               
                   
                 Lung Margin (OD04237-02) 
                 3.1 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 3.2 
               
               
                   
                 Liver Margin (ODO4310) 
                 1.1 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.0 
               
               
                   
                 Lung Margin (OD04321) 
                 17.2 
               
               
                   
                 Normal Kidney 
                 100.0 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 0.0 
               
               
                   
                 Kidney Margin (OD04338) 
                 16.8 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 6.3 
               
               
                   
                 Kidney Margin (OD04339) 
                 59.0 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 10.7 
               
               
                   
                 Kidney Margin (OD04340) 
                 38.4 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 0.8 
               
               
                   
                 Kidney Margin (OD04348) 
                 18.4 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 1.8 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 8.9 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 1.6 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 21.3 
               
               
                   
                 Kidney Cancer 8120607 
                 0.0 
               
               
                   
                 Kidney Margin 8120608 
                 37.1 
               
               
                   
                 Kidney Cancer 8120613 
                 0.0 
               
               
                   
                 Kidney Margin 8120614 
                 31.6 
               
               
                   
                 Kidney Cancer 9010320 
                 4.2 
               
               
                   
                 Kidney Margin 9010321 
                 62.9 
               
               
                   
                 Normal Uterus 
                 1.4 
               
               
                   
                 Uterus Cancer 064011 
                 19.6 
               
               
                   
                 Normal Thyroid 
                 0.6 
               
               
                   
                 Thyroid Cancer 064010 
                 6.6 
               
               
                   
                 Thyroid Cancer A302152 
                 0.0 
               
               
                   
                 Thyroid Margin A302153 
                 1.9 
               
               
                   
                 Normal Breast 
                 22.2 
               
               
                   
                 Breast Cancer (OD04566) 
                 0.8 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 2.6 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 2.0 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 2.9 
               
               
                   
                 Breast Cancer 064006 
                 4.3 
               
               
                   
                 Breast Cancer 1024 
                 6.5 
               
               
                   
                 Breast Cancer 9100266 
                 6.5 
               
               
                   
                 Breast Margin 9100265 
                 15.7 
               
               
                   
                 Breast Cancer A209073 
                 10.7 
               
               
                   
                 Breast Margin A209073 
                 31.4 
               
               
                   
                 Normal Liver 
                 0.0 
               
               
                   
                 Liver Cancer 064003 
                 26.6 
               
               
                   
                 Liver Cancer 1025 
                 0.0 
               
               
                   
                 Liver Cancer 1026 
                 0.0 
               
               
                   
                 Liver Cancer 6004-T 
                 0.0 
               
               
                   
                 Liver Tissue 6004-N 
                 29.1 
               
               
                   
                 Liver Cancer 6005-T 
                 0.0 
               
               
                   
                 Liver Tissue 6005-N 
                 0.0 
               
               
                   
                 Normal Bladder 
                 0.4 
               
               
                   
                 Bladder Cancer 1023 
                 0.0 
               
               
                   
                 Bladder Cancer A302173 
                 39.0 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 0.0 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 4.5 
               
               
                   
                 Normal Ovary 
                 2.6 
               
               
                   
                 Ovarian Cancer 064008 
                 0.0 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 0.0 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 0.0 
               
               
                   
                 Normal Stomach 
                 2.2 
               
               
                   
                 Gastric Cancer 9060358 
                 0.0 
               
               
                   
                 Stomach Margin 9060359 
                 1.3 
               
               
                   
                 Gastric Cancer 9060395 
                 4.6 
               
               
                   
                 Stomach Margin 9060394 
                 5.3 
               
               
                   
                 Gastric Cancer 9060397 
                 2.5 
               
               
                   
                 Stomach Margin 9060396 
                 0.8 
               
               
                   
                 Gastric Cancer 064005 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2443, Run 164988396    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BDD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.0 
               
               
                   
                 LAK cells IL-2 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 0.0 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.1 
               
               
                   
                 PBMC PWM 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 35.6 
               
               
                   
                 Ramos (B cell) ionomycin 
                 100.0 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.5 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.2 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.1 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 0.0 
               
               
                   
                 HUVEC IL-1beta 
                 0.0 
               
               
                   
                 HUVEC IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 0.0 
               
               
                   
                 Lung Microvascular EC none 
                 0.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 0.0 
               
               
                   
                 Small airway epithelium none 
                 0.0 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Coronery artery SMC rest 
                 0.0 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Astrocytes rest 
                 0.0 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.7 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.4 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Liver cirrhosis 
                 0.2 
               
               
                   
                 Lupus kidney 
                 0.1 
               
               
                   
                 NCI-H292 none 
                 0.0 
               
               
                   
                 NCI-H292 IL-4 
                 0.0 
               
               
                   
                 NCI-H292 IL-9 
                 0.0 
               
               
                   
                 NCI-H292 IL-13 
                 0.0 
               
               
                   
                 NCI-H292 IFN gamma 
                 0.0 
               
               
                   
                 HPAEC none 
                 0.2 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.1 
               
               
                   
                 Lung fibroblast none 
                 0.0 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast IL-4 
                 0.0 
               
               
                   
                 Lung fibroblast IL-9 
                 0.0 
               
               
                   
                 Lung fibroblast IL-13 
                 0.0 
               
               
                   
                 Lung fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 0.0 
               
               
                   
                 IBD Colitis 2 
                 0.0 
               
               
                   
                 IBD Crohn&#39;s 
                 0.0 
               
               
                   
                 Colon 
                 0.1 
               
               
                   
                 Lung 
                 0.1 
               
               
                   
                 Thymus 
                 2.5 
               
               
                   
                 Kidney 
                 0.1 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2443, Run 164337611    
               
            
           
         
       
     
      Panel 1.3D Summary: Ag2443 Highest expression of this gene was detected in the cerebral cortex (CT=30.9). In addition, high expression of this gene was observed exclusively in all the brain regions (CTs=31). Expression of this gene is useful as a marker to distinguish these brain samples from other samples used in this panel. Low but significant expression was also seen in spinal cord region. Therefore, therapeutic modulation of the function or activity of this gene or its protein product, through the use of small molecule drugs, protein therapeutics or antibodies, is beneficial in the treatment of central nervous system disorders such as Alzheimer&#39;s disease, Parkinson&#39;s disease, epilepsy, multiple sclerosis, schizophrenia and depression.  
      This gene encodes a variant of cub and sushi multiple domains 1 protein (CSMD1). A related protein, SEZ-6, has recently been shown to be associated with neuronal bursting activity of seizures (Shimizu-Nishikawa K, Brain Res Mol Brain Res 28(2):201-10). Thus, the protein encoded by this gene also plays a role in neuronal siezures.  
      In addition, low to moderate expression of this gene was seen in melanoma, ovarian cancer OVCAR-3, breast cancer, lung cancer, liver adenocarcinoma and glioma U25 1 cell lines. Therapeutic modulation of the activity of this gene or its protein product, through the use of small molecule drugs, or antibodies, is beneficial in the treatment of these cancers.  
      Significant expression was also detected in fetal skeletal muscle.  
      Panel 2D Summary: Ag2443 Highest expression of this gene was detected in a kidney sample (CT=31). Expression of this gene was down-regulated in kidney and lung cancer. In addition, there was substantial expression in other samples derived from bladder cancer, liver cancer, uterine cancer, breast cancer, kidney cancer and lung cancer. This gene encodes a variant of cub and sushi multiple domains 1 protein (CSMD1). Recently, CSMD1 has been shown to be a candidate for tumor suppressor of multiple types of cancer (Sun PC. Genomics 75(1-3):17-25). Therefore, therapeutic modulation of the activity of this gene or its protein product, through the use of small molecule drugs, or antibodies, is beneficial in the treatment of bladder, liver, uterine, breast, kidney and lung cancers.  
      Panel 4D Summary: Ag2443 Highest expression of this gene was seen in Ramos B cells (CTs=26-27). Expression of this gene is useful as a marker to distinguish these samples from other samples in this panel. In addition, expression of this gene in B cells shows that this gene is involved in rheumatic disease including rheumatoid arthritis, lupus, osteoarthritis, and hyperproliferative B cell disorders.  
      Low but significant expression of this gene was also detected in thymus. Drugs that inhibit the function of this protein are useful in the regulation of T cell development in the thymus and for the reduction or elimination of the symptoms of T cell mediated autoimmune or inflammatory diseases, including asthma, allergies, inflammatory bowel disease, lupus erythematosus, or rheumatoid arthritis. Small molecule or antibody therapeutics designed against this putative protein are useful for the disruption of T cell development in the thymus and as immunosuppresants for tissue transplant.  
      BE. CG9271501: KIAA0918  
      Expression of gene CG92715-01 was assessed using the primer-probe set Ag2502, described in Table BEA. Results of the RTQ-PCR runs are shown in Tables BEB, BEC, BED and BEE.  
               TABLE BEA                          Probe Name Ag2502                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-ggagtaaccacttcacctcctt-3′   22   1632   1555                   Probe   TET-5′-ccagctgaagtcactcatccaaatcg-3′-   26   1675   1556           TAMRA               Reverse   5′-aggtacaatcccaaggattgtc-3′   22   1709   1557                  
 
     
       
         
           
               
             
               
                 TABLE BEB 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 4.5 
               
               
                   
                 Pancreas 
                 1.1 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 14.9 
               
               
                   
                 Adrenal gland 
                 0.8 
               
               
                   
                 Thyroid 
                 10.1 
               
               
                   
                 Salivary gland 
                 17.3 
               
               
                   
                 Pituitary gland 
                 2.9 
               
               
                   
                 Brain (fetal) 
                 76.3 
               
               
                   
                 Brain (whole) 
                 95.3 
               
               
                   
                 Brain (amygdala) 
                 80.1 
               
               
                   
                 Brain (cerebellum) 
                 61.1 
               
               
                   
                 Brain (hippocampus) 
                 100.0 
               
               
                   
                 Brain (substantia nigra) 
                 16.2 
               
               
                   
                 Brain (thalamus) 
                 25.0 
               
               
                   
                 Cerebral Cortex 
                 92.0 
               
               
                   
                 Spinal cord 
                 20.0 
               
               
                   
                 glio/astro U87-MG 
                 24.7 
               
               
                   
                 glio/astro U-118-MG 
                 22.4 
               
               
                   
                 astrocytoma SW1783 
                 0.2 
               
               
                   
                 neuro*; met SK-N-AS 
                 42.3 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 3.6 
               
               
                   
                 glioma SNB-19 
                 2.5 
               
               
                   
                 glioma U251 
                 19.5 
               
               
                   
                 glioma SF-295 
                 0.0 
               
               
                   
                 Heart (fetal) 
                 1.3 
               
               
                   
                 Heart 
                 0.8 
               
               
                   
                 Skeletal muscle (fetal) 
                 8.2 
               
               
                   
                 Skeletal muscle 
                 0.0 
               
               
                   
                 Bone marrow 
                 0.0 
               
               
                   
                 Thymus 
                 0.7 
               
               
                   
                 Spleen 
                 0.5 
               
               
                   
                 Lymph node 
                 0.3 
               
               
                   
                 Colorectal 
                 0.7 
               
               
                   
                 Stomach 
                 3.1 
               
               
                   
                 Small intestine 
                 2.4 
               
               
                   
                 Colon ca. SW480 
                 0.2 
               
               
                   
                 Colon ca.* SW620(SW480 met) 
                 1.4 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 Colon ca. tissue(ODO3866) 
                 0.0 
               
               
                   
                 Colon ca. HCC-2998 
                 4.8 
               
               
                   
                 Gastric ca.* (liver met) NCI-N87 
                 0.2 
               
               
                   
                 Bladder 
                 2.6 
               
               
                   
                 Trachea 
                 4.1 
               
               
                   
                 Kidney 
                 0.6 
               
               
                   
                 Kidney (fetal) 
                 1.3 
               
               
                   
                 Renal ca. 786-0 
                 31.2 
               
               
                   
                 Renal ca. A498 
                 4.4 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 1.7 
               
               
                   
                 Renal ca. UO-31 
                 4.2 
               
               
                   
                 Renal ca. TK-10 
                 5.8 
               
               
                   
                 Liver 
                 0.0 
               
               
                   
                 Liver (fetal) 
                 0.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
               
               
                   
                 Lung 
                 0.3 
               
               
                   
                 Lung (fetal) 
                 2.1 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 2.1 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 4.8 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 30.6 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 21.2 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 2.3 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 36.1 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 10.8 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.3 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 3.2 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 23.2 
               
               
                   
                 Mammary gland 
                 1.5 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 4.9 
               
               
                   
                 Breast ca. BT-549 
                 14.2 
               
               
                   
                 Breast ca. MDA-N 
                 1.4 
               
               
                   
                 Ovary 
                 3.6 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 12.9 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 4.1 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 11.7 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca.* (ascites) SK-OV-3 
                 1.6 
               
               
                   
                 Uterus 
                 0.0 
               
               
                   
                 Placenta 
                 0.0 
               
               
                   
                 Prostate 
                 1.2 
               
               
                   
                 Prostate ca.* (bone met)PC-3 
                 0.6 
               
               
                   
                 Testis 
                 0.8 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 1.1 
               
               
                   
                 Melanoma M14 
                 2.7 
               
               
                   
                 Melanoma LOX IMVI 
                 0.8 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 2.3 
               
               
                   
                 Adipose 
                 1.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2502, Run 165518160    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BEC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Normal Colon 
                 7.1 
                 9.9 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 0.0 
                 0.1 
               
               
                   
                 CC Margin (ODO3866) 
                 0.7 
                 0.3 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 0.3 
                 0.0 
               
               
                   
                 CC Margin (ODO3868) 
                 0.4 
                 0.8 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 10.5 
                 11.1 
               
               
                   
                 CC Margin (ODO3920) 
                 1.0 
                 1.5 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 2.8 
                 1.3 
               
               
                   
                 CC Margin (ODO3921) 
                 0.1 
                 0.2 
               
               
                   
                 CC from Partial Hepatectomy 
                 0.0 
                 0.0 
               
               
                   
                 (ODO4309) Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 0.1 
                 0.1 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 0.9 
                 1.3 
               
               
                   
                 Lung Margin (OD04451-02) 
                 0.9 
                 0.4 
               
               
                   
                 Normal Prostate 6546-1 
                 13.8 
                 7.2 
               
               
                   
                 Prostate Cancer (OD04410) 
                 19.1 
                 15.9 
               
               
                   
                 Prostate Margin (OD04410) 
                 7.0 
                 8.5 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 33.2 
                 34.9 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 43.5 
                 56.6 
               
               
                   
                 Normal Lung 061010 
                 2.8 
                 3.0 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 15.8 
                 14.3 
               
               
                   
                 Muscle Margin (ODO4286) 
                 0.5 
                 0.6 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 0.9 
                 0.7 
               
               
                   
                 Lung Margin (OD03126) 
                 1.2 
                 1.9 
               
               
                   
                 Lung Cancer (OD04404) 
                 0.3 
                 0.3 
               
               
                   
                 Lung Margin (OD04404) 
                 0.4 
                 0.5 
               
               
                   
                 Lung Cancer (OD04565) 
                 0.1 
                 0.5 
               
               
                   
                 Lung Margin (OD04565) 
                 0.3 
                 1.0 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 1.7 
                 1.7 
               
               
                   
                 Lung Margin (OD04237-02) 
                 0.1 
                 0.0 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 0.0 
                 0.0 
               
               
                   
                 Liver Margin (ODO4310) 
                 0.2 
                 0.0 
               
               
                   
                 Melanoma Mets to Lung (OD04321) 
                 0.0 
                 0.1 
               
               
                   
                 Lung Margin (OD04321) 
                 0.4 
                 0.6 
               
               
                   
                 Normal Kidney 
                 2.3 
                 1.9 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 2.8 
                 2.9 
               
               
                   
                 Kidney Margin (OD04338) 
                 0.4 
                 0.3 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 0.4 
                 0.3 
               
               
                   
                 Kidney Margin (OD04339) 
                 0.4 
                 0.9 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 27.4 
                 33.2 
               
               
                   
                 Kidney Margin (OD04340) 
                 0.2 
                 0.3 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 3.0 
                 3.0 
               
               
                   
                 Kidney Margin (OD04348) 
                 0.4 
                 0.0 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 100.0 
                 100.0 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 0.0 
                 0.5 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.1 
                 0.8 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 0.8 
                 0.7 
               
               
                   
                 Kidney Cancer 8120607 
                 4.7 
                 3.7 
               
               
                   
                 Kidney Margin 8120608 
                 0.1 
                 0.1 
               
               
                   
                 Kidney Cancer 8120613 
                 0.0 
                 0.1 
               
               
                   
                 Kidney Margin 8120614 
                 0.2 
                 0.6 
               
               
                   
                 Kidney Cancer 9010320 
                 1.4 
                 2.1 
               
               
                   
                 Kidney Margin 9010321 
                 0.6 
                 0.2 
               
               
                   
                 Normal Uterus 
                 0.1 
                 0.1 
               
               
                   
                 Uterus Cancer 064011 
                 0.3 
                 0.7 
               
               
                   
                 Normal Thyroid 
                 14.5 
                 13.5 
               
               
                   
                 Thyroid Cancer 064010 
                 0.4 
                 0.3 
               
               
                   
                 Thyroid Cancer A302152 
                 0.2 
                 0.6 
               
               
                   
                 Thyroid Margin A302153 
                 14.9 
                 12.4 
               
               
                   
                 Normal Breast 
                 1.7 
                 2.6 
               
               
                   
                 Breast Cancer (OD04566) 
                 0.1 
                 0.2 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 5.5 
                 5.1 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 4.2 
                 2.6 
               
               
                   
                 Breast Cancer Metastasis (OD04655-05) 
                 1.0 
                 0.9 
               
               
                   
                 Breast Cancer 064006 
                 1.3 
                 0.4 
               
               
                   
                 Breast Cancer 1024 
                 2.1 
                 1.1 
               
               
                   
                 Breast Cancer 9100266 
                 0.1 
                 0.1 
               
               
                   
                 Breast Margin 9100265 
                 2.5 
                 2.5 
               
               
                   
                 Breast Cancer A209073 
                 2.4 
                 0.6 
               
               
                   
                 Breast Margin A209073 
                 3.7 
                 3.3 
               
               
                   
                 Normal Liver 
                 0.0 
                 0.1 
               
               
                   
                 Liver Cancer 064003 
                 0.6 
                 1.2 
               
               
                   
                 Liver Cancer 1025 
                 0.0 
                 0.0 
               
               
                   
                 Liver Cancer 1026 
                 0.0 
                 0.1 
               
               
                   
                 Liver Cancer 6004-T 
                 0.0 
                 0.0 
               
               
                   
                 Liver Tissue 6004-N 
                 0.3 
                 0.2 
               
               
                   
                 Liver Cancer 6005-T 
                 0.1 
                 0.0 
               
               
                   
                 Liver Tissue 6005-N 
                 0.0 
                 0.0 
               
               
                   
                 Normal Bladder 
                 6.5 
                 4.0 
               
               
                   
                 Bladder Cancer 1023 
                 0.0 
                 0.3 
               
               
                   
                 Bladder Cancer A302173 
                 24.0 
                 23.5 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 0.0 
                 0.0 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 0.1 
                 0.1 
               
               
                   
                 Normal Ovary 
                 2.1 
                 3.9 
               
               
                   
                 Ovarian Cancer 064008 
                 4.9 
                 6.3 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 10.4 
                 7.8 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 0.4 
                 0.2 
               
               
                   
                 Normal Stomach 
                 6.2 
                 5.2 
               
               
                   
                 Gastric Cancer 9060358 
                 3.1 
                 7.5 
               
               
                   
                 Stomach Margin 9060359 
                 1.3 
                 0.8 
               
               
                   
                 Gastric Cancer 9060395 
                 4.7 
                 4.3 
               
               
                   
                 Stomach Margin 9060394 
                 1.5 
                 1.3 
               
               
                   
                 Gastric Cancer 9060397 
                 1.4 
                 1.2 
               
               
                   
                 Stomach Margin 9060396 
                 0.2 
                 0.2 
               
               
                   
                 Gastric Cancer 064005 
                 4.7 
                 3.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2502, Run 162319639    
               
               
                   
                   Column B - Rel. Exp. (%) Ag2502, Run 164993363    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BED 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Daoy- Medulloblastoma 
                 1.6 
               
               
                   
                 TE671- Medulloblastoma 
                 41.8 
               
               
                   
                 D283 Med- Medulloblastoma 
                 63.7 
               
               
                   
                 PFSK-1- Primitive Neuroectodermal 
                 0.0 
               
               
                   
                 XF-498- CNS 
                 22.8 
               
               
                   
                 SNB-78- Glioma 
                 11.8 
               
               
                   
                 SF-268- Glioblastoma 
                 5.1 
               
               
                   
                 T98G- Glioblastoma 
                 0.0 
               
               
                   
                 SK-N-SH- Neuroblastoma (metastasis) 
                 0.0 
               
               
                   
                 SF-295- Glioblastoma 
                 0.8 
               
               
                   
                 Cerebellum 
                 79.0 
               
               
                   
                 Cerebellum 
                 26.4 
               
               
                   
                 NCI-H292- Mucoepidermoid lung carcinoma 
                 1.5 
               
               
                   
                 DMS-114- Small cell lung cancer 
                 13.2 
               
               
                   
                 DMS-79- Small cell lung cancer 
                 0.0 
               
               
                   
                 NCI-H146- Small cell lung cancer 
                 28.5 
               
               
                   
                 NCI-H526- Small cell lung cancer 
                 3.1 
               
               
                   
                 NCI-N417- Small cell lung cancer 
                 46.3 
               
               
                   
                 NCI-H82- Small cell lung cancer 
                 87.1 
               
               
                   
                 NCI-H157- Squamous cell lung cancer (metastasis) 
                 100.0 
               
               
                   
                 NCI-H1155- Large cell lung cancer 
                 35.6 
               
               
                   
                 NCI-H1299- Large cell lung cancer 
                 16.5 
               
               
                   
                 NCI-H727- Lung carcinoid 
                 0.0 
               
               
                   
                 NCI-UMC-11- Lung carcinoid 
                 53.2 
               
               
                   
                 LX-1- Small cell lung cancer 
                 1.2 
               
               
                   
                 Colo-205- Colon cancer 
                 5.9 
               
               
                   
                 KM12- Colon cancer 
                 0.0 
               
               
                   
                 KM20L2- Colon cancer 
                 0.0 
               
               
                   
                 NCI-H716- Colon cancer 
                 0.0 
               
               
                   
                 SW-48- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW1116- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 LS 174T- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-948- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 SW-480- Colon adenocarcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-5- Gastric carcinoma 
                 0.0 
               
               
                   
                 KATO III- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-SNU-16- Gastric carcinoma 
                 6.7 
               
               
                   
                 NCI-SNU-1- Gastric carcinoma 
                 0.0 
               
               
                   
                 RF-1- Gastric adenocarcinoma 
                 2.4 
               
               
                   
                 RF-48- Gastric adenocarcinoma 
                 2.6 
               
               
                   
                 MKN-45- Gastric carcinoma 
                 0.0 
               
               
                   
                 NCI-N87- Gastric carcinoma 
                 0.0 
               
               
                   
                 OVCAR-5- Ovarian carcinoma 
                 0.0 
               
               
                   
                 RL95-2- Uterine carcinoma 
                 1.7 
               
               
                   
                 HelaS3- Cervical adenocarcinoma 
                 14.6 
               
               
                   
                 Ca Ski- Cervical epidermoid carcinoma (metastasis) 
                 1.2 
               
               
                   
                 ES-2- Ovarian clear cell carcinoma 
                 22.5 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 6 h 
                 0.0 
               
               
                   
                 Ramos- Stimulated with PMA/ionomycin 14 h 
                 0.0 
               
               
                   
                 MEG-01- Chronic myelogenous leukemia 
                 13.8 
               
               
                   
                 (megokaryoblast) 
               
               
                   
                 Raji- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 Daudi- Burkitt&#39;s lymphoma 
                 0.0 
               
               
                   
                 U266- B-cell plasmacytoma 
                 8.5 
               
               
                   
                 CA46- Burkitt&#39;s lymphoma 
                 6.3 
               
               
                   
                 RL- non-Hodgkin&#39;s B-cell lymphoma 
                 0.0 
               
               
                   
                 JM1- pre-B-cell lymphoma 
                 0.0 
               
               
                   
                 Jurkat- T cell leukemia 
                 0.0 
               
               
                   
                 TF-1- Erythroleukemia 
                 11.8 
               
               
                   
                 HUT 78- T-cell lymphoma 
                 0.0 
               
               
                   
                 U937- Histiocytic lymphoma 
                 0.0 
               
               
                   
                 KU-812- Myelogenous leukemia 
                 0.3 
               
               
                   
                 769-P- Clear cell renal carcinoma 
                 9.5 
               
               
                   
                 Caki-2- Clear cell renal carcinoma 
                 3.1 
               
               
                   
                 SW 839- Clear cell renal carcinoma 
                 12.5 
               
               
                   
                 Rhabdoid kidney tumor 
                 12.6 
               
               
                   
                 Hs766T- Pancreatic carcinoma (LN metastasis) 
                 0.0 
               
               
                   
                 CAPAN-1- Pancreatic adenocarcinoma (liver 
                 0.0 
               
               
                   
                 metastasis) 
               
               
                   
                 SU86.86- Pancreatic carcinoma (liver metastasis) 
                 2.4 
               
               
                   
                 BxPC-3- Pancreatic adenocarcinoma 
                 0.0 
               
               
                   
                 HPAC- Pancreatic adenocarcinoma 
                 0.0 
               
               
                   
                 MIA PaCa-2- Pancreatic carcinoma 
                 0.7 
               
               
                   
                 CFPAC-1- Pancreatic ductal adenocarcinoma 
                 0.4 
               
               
                   
                 PANC-1- Pancreatic epithelioid ductal carcinoma 
                 1.3 
               
               
                   
                 T24- Bladder carcinma (transitional cell) 
                 0.0 
               
               
                   
                 5637- Bladder carcinoma 
                 7.7 
               
               
                   
                 HT-1197- Bladder carcinoma 
                 0.0 
               
               
                   
                 UM-UC-3- Bladder carcinma (transitional cell) 
                 3.1 
               
               
                   
                 A204- Rhabdomyosarcoma 
                 0.0 
               
               
                   
                 HT-1080- Fibrosarcoma 
                 2.6 
               
               
                   
                 MG-63- Osteosarcoma 
                 4.6 
               
               
                   
                 SK-LMS-1- Leiomyosarcoma (vulva) 
                 0.3 
               
               
                   
                 SJRH30- Rhabdomyosarcoma (met to bone marrow) 
                 22.8 
               
               
                   
                 A431- Epidermoid carcinoma 
                 0.0 
               
               
                   
                 WM266-4- Melanoma 
                 15.8 
               
               
                   
                 DU 145- Prostate carcinoma (brain metastasis) 
                 0.0 
               
               
                   
                 MDA-MB-468- Breast adenocarcinoma 
                 0.3 
               
               
                   
                 SCC-4- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-9- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 SCC-15- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                 CAL 27- Squamous cell carcinoma of tongue 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2502, Run 164629448    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BEE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 1.6 
               
               
                   
                 Secondary Th2 act 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
               
               
                   
                 Primary Th1 act 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 1.8 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
               
               
                   
                 CD8 lymphocyte act 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 3.1 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 1.1 
               
               
                   
                 LAK cells rest 
                 4.1 
               
               
                   
                 LAK cells IL-2 
                 6.6 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.0 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 2.4 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 4.4 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
               
               
                   
                 NK Cells IL-2 rest 
                 2.4 
               
               
                   
                 Two Way MLR 3 day 
                 0.0 
               
               
                   
                 Two Way MLR 5 day 
                 0.0 
               
               
                   
                 Two Way MLR 7 day 
                 0.0 
               
               
                   
                 PBMC rest 
                 7.8 
               
               
                   
                 PBMC PWM 
                 6.7 
               
               
                   
                 PBMC PHA-L 
                 0.0 
               
               
                   
                 Ramos (B cell) none 
                 6.6 
               
               
                   
                 Ramos (B cell) ionomycin 
                 8.8 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 100.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 18.2 
               
               
                   
                 Dendritic cells none 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
               
               
                   
                 Monocytes rest 
                 3.5 
               
               
                   
                 Monocytes LPS 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
               
               
                   
                 Macrophages LPS 
                 0.0 
               
               
                   
                 HUVEC none 
                 0.0 
               
               
                   
                 HUVEC starved 
                 23.3 
               
               
                   
                 HUVEC IL-1beta 
                 3.5 
               
               
                   
                 HUVEC IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 0.0 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 0.0 
               
               
                   
                 HUVEC IL-11 
                 3.7 
               
               
                   
                 Lung Microvascular EC none 
                 2.8 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EG TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 9.7 
               
               
                   
                 Small airway epithelium none 
                 23.0 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Coronery artery SMC rest 
                 0.0 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Astrocytes rest 
                 21.6 
               
               
                   
                 Astrocytes TNFalpha + IL-1 beta 
                 4.1 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 46.3 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 2.5 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 6.9 
               
               
                   
                 Liver cirrhosis 
                 16.6 
               
               
                   
                 Lupus kidney 
                 2.6 
               
               
                   
                 NCI-H292 none 
                 57.8 
               
               
                   
                 NCI-H292 IL-4 
                 26.8 
               
               
                   
                 NCI-H292 IL-9 
                 54.3 
               
               
                   
                 NCI-H292 IL-13 
                 24.0 
               
               
                   
                 NCI-H292 IFN gamma 
                 20.7 
               
               
                   
                 HPAEC none 
                 0.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast none 
                 5.8 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast IL-4 
                 31.4 
               
               
                   
                 Lung fibroblast IL-9 
                 7.6 
               
               
                   
                 Lung fibroblast IL-13 
                 3.0 
               
               
                   
                 Lung fibroblast IFN gamma 
                 5.3 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 9.5 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.0 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.0 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 0.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 0.0 
               
               
                   
                 IBD Colitis 2 
                 6.0 
               
               
                   
                 IBD Crohn&#39;s 
                 1.3 
               
               
                   
                 Colon 
                 31.4 
               
               
                   
                 Lung 
                 56.3 
               
               
                   
                 Thymus 
                 25.3 
               
               
                   
                 Kidney 
                 12.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2502, Run 162293442    
               
            
           
         
       
     
      Panel 1.3D Summary: Ag2502 Highest expression of this gene was seen in the cerebral cortex (CT=27). In addition, low levels of expression were seen in all CNS regions examined in this panel. This gene encodes a leucine-rich repeat protein. Leucine rich repeats (LRR) mediate reversible protein-protein interactions and have diverse cellular functions, including cellular adhesion and signaling. Several of these proteins, such as connectin, slit, chaoptin, and Toll have pivotal roles in neuronal development in  Drosophila  and play significant but distinct roles in neural development and in the adult nervous system of humans (Battye R. J. Neurosci. 21: 4290-4298). In  Drosophilia,  the LRR region of axon guidance proteins are critical for their function , especially in axon repulsion. Since the leucine-rich-repeat protein encoded by this gene was highly expressed in the cerebral cortex, it is a candidate neuronal guidance protein for axons, dendrites and/or growth cones in general. (Itoh A. Brain Res. Mol. Brain Res. 62: 175-186.) Therapeutic modulation of the levels of this protein, or signaling via this protein, are of utility in enhancing/directing compensatory synaptogenesis and fiber growth in the CNS in response to neuronal death (stroke, head trauma), axon lesion (spinal cord injury), or neurodegeneration (Alzheimer&#39;s, Parkinson&#39;s, Huntington&#39;s, vascular dementia or any neurodegenerative disease).  
      Moderate levels of expression were also seen in cell lines derived from ovarian cancer, lung cancer, and brain cancer. Therapeutic modulation of the expression or function of this gene or gene product is an effective treatment of these cancers.  
      Among metabolically relevant tissues, this gene was expressed in fetal skeletal muscle, thyroid, and pituitary gland. Therapeutic modulation of this gene or gene product is useful in the treatment of metabolic diseases such as obesity and diabetes, as well as neuroendocrine disorders. Glycoprotein hormones influence the development and function of the ovary, testis and thyroid by binding to specific high-affinity receptors. (Jiang X. Structure 3: 1341-1353). The extracellular domains of these receptors are members of the leucine-rich repeat (LRR) protein superfamily and are responsible for the high-affinity binding.  
      Panel 2D Summary: Ag2502 Highest expression of this gene was seen in kidney cancer (CTs=27.7). In addition, expression was significantly higher in the kidney cancer samples when compared to expression in samples from the normal adjacent tissue. There was also moderate to low expression in bladder, gastric, colon and ovarian cancers. Expression of this gene is useful as a marker to differentiate the kidney cancer samples from other samples on this panel and as a marker for kidney cancer. Therapeutic targeting of this gene or its protein product with a human monoclonal antibody, small molecule, or protein therapeutic is useful for limiting or blocking the extent of tumor cell migration, invasion, and metastasis, specifically in kidney, ovarian, bladder, gastric, and colon tumors.  
      Panel 3D Summary: Ag2502 Highest expression of this gene was seen in a lung cancer cell line (CT=28). Moderate levels of expression were seen in a cluster of lung and brain cancer cell lines. Prominent expression was also seen in cerebellum, in agreement with expression seen in Panel 1.3D. Low, but significant expression was also seen in kidney cancer and ovarian cancer cell lines. Expression of this gene is useful as a marker to differentiate lung and brain cancer cell lines and normal brain from other samples on this panel and as a marker for lung and brain cancer. Moderate expression of this gene was also seen in melanoma, rhabdomyosarcoma, osteosarcoma, renal and bladder carcinoma, lymphoma, ovarian and cervical cancer and gastric cancer cell lines. Therapeutic modulation of the expression or function of this gene is useful for the treatment of these cancers.  
      Panel 4D Summary: Ag2502 Ag2502 Highest expression of this gene was seen in eosinophils (CT=32). Higher levels of gene expression were observed in the eosinophil cell line EOL-1 under resting conditions over the levels in EOL-1 cells stimulated by phorbol ester and ionomycin (CT=34.4). Thus, this gene is involved in eosinophil function. Antibodies raised against this protein that stimulate its activity are useful in the reduction of eosinophil activation and as therapeutic antibodies for the treatment of asthma and allergy and as an anti-inflammatory therapeutics for T cell-mediated autoimmune and inflammatory diseases. Low but significant levels of expression were also seen in a cluster of treated and untreated NCI-H292 mucoepidermoid cells adn in normal colon, lung and thymus. This pattern of restricted expression shows that this gene or gene product is involved in the normal homeostasis of these tissues and/or pathological/inflammatory conditions of the lung.  
      BF. CG92813-01: Cadherin-related Tumor Suppressor Precursor (FAT)  
      Expression of gene CG92813-01 was assessed using the primer-probe sets Ag1413, Ag1515, Ag3085, Ag740 and Ag3819, described in Tables BFA, BFB, BFC, BFD, and BFE. Results of the RTQ-PCR runs are shown in Tables BFF, BFG, BFH and BFI.  
               TABLE BFA                          Probe Name Ag1413                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-aggattctggtgttcctcaaat-3′   22   10908   1558                   Probe   TET-5′-tcttccacaggaactgtgcatatcaca-3′-   27   10931   1559           TAMRA               Reverse   5′-cgagactgtgaaggattgtcat-3′   22   10971   1560                  
 
     
       
         
           
               
             
               
                 TABLE BFB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag1515 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-ggatggttccatatcagtgaac-3′ 
                 22 
                 2078 
                 1561 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ctcgtgaccactgggtcctctgg-3′-TAMRA 
                 23 
                 2108 
                 1562 
               
               
                   
               
               
                 Reverse 
                 5′-agaacaatctgggaagcaagtt-3′ 
                 22 
                 2145 
                 1563 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BFC 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag3085 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-cttcacctgtagctgccca-3′ 
                 19 
                 13801 
                 1564 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-acacgggaaggacctgtgagatggt-3′- 
                 25 
                 13827 
                 1565 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-acagaggacgccaagacag-3′ 
                 19 
                 13858 
                 1566 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BFD 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag740 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-gagggatattgtcagggtcatc-3′ 
                 22 
                 14126 
                 1567 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-aaaagcaacgttctcacttccctttt-3′- 
                 26 
                 14100 
                 1568 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-aaatcccaaagaggagaagaaa-3′ 
                 22 
                 14062 
                 1569 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BFE 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag3819 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-agtcatcaatggctcgcata-3′ 
                 20 
                 2523 
                 1570 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-tcttctggatataaatgataacagccctg-3′- 
                 29 
                 2551 
                 1571 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-aagtattggaccgggtagaaga-3′ 
                 22 
                 2580 
                 1572 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BFF 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.4 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Adipose 
                 11.3 
                 5.8 
               
               
                   
                 Melanoma* Hs688(A).T 
                 84.1 
                 68.8 
               
               
                   
                 Melanoma* Hs688(B).T 
                 29.7 
                 20.7 
               
               
                   
                 Melanoma* M14 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* LOXIMVI 
                 17.7 
                 14.6 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.7 
                 1.2 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 2.2 
                 2.2 
               
               
                   
                 Testis Pool 
                 4.5 
                 4.1 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 5.0 
                 3.5 
               
               
                   
                 Prostate Pool 
                 10.6 
                 7.7 
               
               
                   
                 Placenta 
                 2.5 
                 3.7 
               
               
                   
                 Uterus Pool 
                 4.6 
                 5.8 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 3.6 
                 2.9 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 46.0 
                 7.7 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 10.4 
                 7.9 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 5.8 
                 3.7 
               
               
                   
                 Ovarian ca. IGROV-1 
                 1.8 
                 1.5 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 3.7 
                 3.3 
               
               
                   
                 Ovary 
                 25.2 
                 13.6 
               
               
                   
                 Breast ca. MCF-7 
                 0.4 
                 0.2 
               
               
                   
                 Breast ca. MDA-MB-231 
                 54.3 
                 40.1 
               
               
                   
                 Breast ca. BT 549 
                 32.5 
                 28.7 
               
               
                   
                 Breast ca. T47D 
                 7.2 
                 5.6 
               
               
                   
                 Breast ca. MDA-N 
                 0.1 
                 0.1 
               
               
                   
                 Breast Pool 
                 48.6 
                 15.9 
               
               
                   
                 Trachea 
                 8.8 
                 11.3 
               
               
                   
                 Lung 
                 6.0 
                 5.9 
               
               
                   
                 Fetal Lung 
                 70.7 
                 59.5 
               
               
                   
                 Lung ca. NCI-N417 
                 42.9 
                 0.3 
               
               
                   
                 Lung ca. LX-1 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. NCI-H146 
                 0.5 
                 0.2 
               
               
                   
                 Lung ca. SHP-77 
                 2.8 
                 2.5 
               
               
                   
                 Lung ca. A549 
                 1.4 
                 1.7 
               
               
                   
                 Lung ca. NCI-H526 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. NCI-H23 
                 100.0 
                 100.0 
               
               
                   
                 Lung ca. NCI-H460 
                 44.1 
                 6.5 
               
               
                   
                 Lung ca. HOP-62 
                 29.9 
                 20.6 
               
               
                   
                 Lung ca. NCI-H522 
                 1.1 
                 1.6 
               
               
                   
                 Liver 
                 1.4 
                 0.6 
               
               
                   
                 Fetal Liver 
                 16.7 
                 13.5 
               
               
                   
                 Liver ca. HepG2 
                 0.4 
                 0.6 
               
               
                   
                 Kidney Pool 
                 35.8 
                 24.7 
               
               
                   
                 Fetal Kidney 
                 48.6 
                 25.7 
               
               
                   
                 Renal ca. 786-0 
                 37.6 
                 30.8 
               
               
                   
                 Renal ca. A498 
                 7.6 
                 6.0 
               
               
                   
                 Renal ca. ACHN 
                 5.6 
                 3.4 
               
               
                   
                 Renal ca. UO-31 
                 37.4 
                 22.7 
               
               
                   
                 Renal ca. TK-10 
                 6.4 
                 4.6 
               
               
                   
                 Bladder 
                 6.4 
                 4.5 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 0.9 
                 0.5 
               
               
                   
                 Gastric ca. KATO III 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. SW-948 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HT29 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 1.3 
                 1.2 
               
               
                   
                 Colon ca. CaCo-2 
                 0.1 
                 0.0 
               
               
                   
                 Colon cancer tissue 
                 7.4 
                 4.0 
               
               
                   
                 Colon ca. SW1116 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. Colo-205 
                 42.3 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
                 0.0 
               
               
                   
                 Colon Pool 
                 14.9 
                 11.9 
               
               
                   
                 Small Intestine Pool 
                 17.8 
                 16.6 
               
               
                   
                 Stomach Pool 
                 48.0 
                 15.0 
               
               
                   
                 Bone Marrow Pool 
                 6.3 
                 7.2 
               
               
                   
                 Fetal Heart 
                 12.7 
                 8.0 
               
               
                   
                 Heart Pool 
                 7.9 
                 6.8 
               
               
                   
                 Lymph Node Pool 
                 21.6 
                 19.1 
               
               
                   
                 Fetal Skeletal Muscle 
                 9.7 
                 11.2 
               
               
                   
                 Skeletal Muscle Pool 
                 5.0 
                 3.9 
               
               
                   
                 Spleen Pool 
                 14.8 
                 16.3 
               
               
                   
                 Thymus Pool 
                 16.3 
                 16.2 
               
               
                   
                 CMS cancer (glio/astro) U87-MG 
                 6.4 
                 6.1 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 48.0 
                 14.8 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 50.0 
                 28.3 
               
               
                   
                 CNS cancer (astro) SF-539 
                 22.7 
                 16.5 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 38.7 
                 38.7 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 2.7 
                 2.4 
               
               
                   
                 CNS cancer (glio) SF-295 
                 27.9 
                 16.8 
               
               
                   
                 Brain (Amygdala) Pool 
                 7.1 
                 4.1 
               
               
                   
                 Brain (cerebellum) 
                 0.7 
                 0.5 
               
               
                   
                 Brain (fetal) 
                 75.3 
                 52.5 
               
               
                   
                 Brain (Hippocampus) Pool 
                 7.9 
                 6.2 
               
               
                   
                 Cerebral Cortex Pool 
                 4.7 
                 4.2 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 4.4 
                 3.2 
               
               
                   
                 Brain (Thalamus) Pool 
                 9.0 
                 5.4 
               
               
                   
                 Brain (whole) 
                 44.4 
                 4.1 
               
               
                   
                 Spinal Cord Pool 
                 6.8 
                 4.5 
               
               
                   
                 Adrenal Gland 
                 2.3 
                 2.1 
               
               
                   
                 Pituitary gland Pool 
                 1.2 
                 0.9 
               
               
                   
                 Salivary Gland 
                 0.9 
                 0.8 
               
               
                   
                 Thyroid (female) 
                 7.8 
                 4.7 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 5.3 
                 4.5 
               
               
                   
                 Pancreas Pool 
                 20.2 
                 14.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1413, Run 213323517    
               
               
                   
                   Column B - Rel. Exp. (%) Ag3819, Run 218713598    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BFG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Normal Colon 
                 68.3 
                 100.0 
               
               
                 CC Well to Mod Diff (ODO3866) 
                 6.3 
                 5.0 
               
               
                 CC Margin (ODO3866) 
                 7.9 
                 25.7 
               
               
                 CC Gr.2 rectosigmoid (ODO3868) 
                 4.6 
                 12.6 
               
               
                 CC Margin (ODO3868) 
                 11.0 
                 38.2 
               
               
                 CC Mod Diff (ODO3920) 
                 1.4 
                 9.7 
               
               
                 CC Margin (ODO3920) 
                 12.1 
                 54.3 
               
               
                 CC Gr.2 ascend colon (ODO3921) 
                 20.3 
                 61.6 
               
               
                 CC Margin (ODO3921) 
                 10.9 
                 12.9 
               
               
                 CC from Partial Hepatectomy (ODO4309) Mets 
                 4.9 
                 3.3 
               
               
                 Liver Margin (ODO4309) 
                 10.4 
                 9.0 
               
               
                 Colon mets to lung (OD04451-01) 
                 2.9 
                 1.4 
               
               
                 Lung Margin (OD04451-02) 
                 10.2 
                 11.5 
               
               
                 Normal Prostate 6546-1 
                 2.7 
                 5.1 
               
               
                 Prostate Cancer (OD04410) 
                 18.4 
                 12.2 
               
               
                 Prostate Margin (OD04410) 
                 36.1 
                 44.4 
               
               
                 Prostate Cancer (OD04720-01) 
                 17.3 
                 28.9 
               
               
                 Prostate Margin (OD04720-02) 
                 28.5 
                 39.5 
               
               
                 Normal Lung 061010 
                 48.0 
                 38.4 
               
               
                 Lung Met to Muscle (ODO4286) 
                 3.6 
                 3.0 
               
               
                 Muscle Margin (ODO4286) 
                 5.9 
                 3.5 
               
               
                 Lung Malignant Cancer (OD03126) 
                 11.7 
                 9.7 
               
               
                 Lung Margin (OD03126) 
                 40.3 
                 24.7 
               
               
                 Lung Cancer (OD04404) 
                 18.0 
                 2.7 
               
               
                 Lung Margin (OD04404) 
                 32.8 
                 9.0 
               
               
                 Lung Cancer (OD04565) 
                 2.9 
                 2.7 
               
               
                 Lung Margin (OD04565) 
                 8.0 
                 10.2 
               
               
                 Lung Cancer (OD04237-01) 
                 4.5 
                 4.0 
               
               
                 Lung Margin (OD04237-02) 
                 31.4 
                 17.9 
               
               
                 Ocular Mel Met to Liver (ODO4310) 
                 0.9 
                 0.3 
               
               
                 Liver Margin (ODO4310) 
                 8.1 
                 10.8 
               
               
                 Melanoma Mets to Lung (OD04321) 
                 2.8 
                 1.5 
               
               
                 Lung Margin (OD04321) 
                 33.9 
                 19.2 
               
               
                 Normal Kidney 
                 100.0 
                 28.5 
               
               
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 14.1 
                 9.8 
               
               
                 Kidney Margin (OD04338) 
                 24.0 
                 7.1 
               
               
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 14.3 
                 6.7 
               
               
                 Kidney Margin (OD04339) 
                 22.8 
                 4.5 
               
               
                 Kidney Ca, Clear cell type (OD04340) 
                 53.2 
                 16.0 
               
               
                 Kidney Margin (OD04340) 
                 26.6 
                 10.5 
               
               
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 8.9 
                 3.6 
               
               
                 Kidney Margin (OD04348) 
                 14.1 
                 10.0 
               
               
                 Kidney Cancer (OD04622-01) 
                 27.4 
                 27.4 
               
               
                 Kidney Margin (OD04622-03) 
                 3.5 
                 4.4 
               
               
                 Kidney Cancer (OD04450-01) 
                 8.4 
                 2.6 
               
               
                 Kidney Margin (OD04450-03) 
                 23.8 
                 7.5 
               
               
                 Kidney Cancer 8120607 
                 1.3 
                 0.4 
               
               
                 Kidney Margin 8120608 
                 2.9 
                 1.0 
               
               
                 Kidney Cancer 8120613 
                 0.2 
                 0.5 
               
               
                 Kidney Margin 8120614 
                 6.3 
                 2.0 
               
               
                 Kidney Cancer 9010320 
                 23.0 
                 2.4 
               
               
                 Kidney Margin 9010321 
                 11.7 
                 1.7 
               
               
                 Normal Uterus 
                 13.8 
                 4.6 
               
               
                 Uterus Cancer 064011 
                 17.8 
                 9.3 
               
               
                 Normal Thyroid 
                 13.6 
                 10.4 
               
               
                 Thyroid Cancer 064010 
                 12.9 
                 6.4 
               
               
                 Thyroid Cancer A302152 
                 8.1 
                 5.4 
               
               
                 Thyroid Margin A302153 
                 29.1 
                 11.0 
               
               
                 Normal Breast 
                 21.0 
                 13.5 
               
               
                 Breast Cancer (OD04566) 
                 1.8 
                 1.2 
               
               
                 Breast Cancer (OD04590-01) 
                 17.3 
                 1.1 
               
               
                 Breast Cancer Mets (OD04590-03) 
                 23.3 
                 3.7 
               
               
                 Breast Cancer Metastasis (OD04655-05) 
                 4.2 
                 0.8 
               
               
                 Breast Cancer 064006 
                 5.2 
                 3.9 
               
               
                 Breast Cancer 1024 
                 12.8 
                 1.8 
               
               
                 Breast Cancer 9100266 
                 3.9 
                 1.7 
               
               
                 Breast Margin 9100265 
                 10.2 
                 5.0 
               
               
                 Breast Cancer A209073 
                 12.2 
                 10.1 
               
               
                 Breast Margin A209073 
                 11.7 
                 9.0 
               
               
                 Normal Liver 
                 7.1 
                 4.4 
               
               
                 Liver Cancer 064003 
                 10.3 
                 8.0 
               
               
                 Liver Cancer 1025 
                 5.0 
                 5.1 
               
               
                 Liver Cancer 1026 
                 3.0 
                 1.5 
               
               
                 Liver Cancer 6004-T 
                 5.4 
                 0.7 
               
               
                 Liver Tissue 6004-N 
                 1.4 
                 0.3 
               
               
                 Liver Cancer 6005-T 
                 5.2 
                 0.5 
               
               
                 Liver Tissue 6005-N 
                 3.3 
                 3.5 
               
               
                 Normal Bladder 
                 7.1 
                 7.7 
               
               
                 Bladder Cancer 1023 
                 1.0 
                 4.1 
               
               
                 Bladder Cancer A302173 
                 3.0 
                 3.6 
               
               
                 Bladder Cancer (OD04718-01) 
                 6.0 
                 4.4 
               
               
                 Bladder Normal Adjacent (OD04718-03) 
                 27.5 
                 25.2 
               
               
                 Normal Ovary 
                 6.7 
                 4.8 
               
               
                 Ovarian Cancer 064008 
                 27.0 
                 21.9 
               
               
                 Ovarian Cancer (OD04768-07) 
                 0.7 
                 0.2 
               
               
                 Ovary Margin (OD04768-08) 
                 12.4 
                 6.7 
               
               
                 Normal Stomach 
                 27.4 
                 12.3 
               
               
                 Gastric Cancer 9060358 
                 6.9 
                 2.1 
               
               
                 Stomach Margin 9060359 
                 7.2 
                 10.9 
               
               
                 Gastric Cancer 9060395 
                 29.9 
                 21.0 
               
               
                 Stomach Margin 9060394 
                 13.7 
                 16.3 
               
               
                 Gastric Cancer 9060397 
                 23.2 
                 18.3 
               
               
                 Stomach Margin 9060396 
                 3.7 
                 2.6 
               
               
                 Gastric Cancer 064005 
                 18.3 
                 26.8 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag1413, Run 169477489    
               
               
                   Column B - Rel. Exp. (%) Ag740, Run 169590466    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BFH 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
               
            
               
                 Tissue Name 
                 A 
                 B 
                 C 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Secondary Th1 act 
                 0.0 
                 0.1 
                 0.0 
               
               
                 Secondary Th2 act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 act 
                 0.0 
                 0.1 
                 0.0 
               
               
                 Secondary Th1 rest 
                 0.0 
                 0.1 
                 0.0 
               
               
                 Secondary Th2 rest 
                 0.2 
                 0.0 
                 0.0 
               
               
                 Secondary Tr1 rest 
                 0.0 
                 0.1 
                 0.0 
               
               
                 Primary Th1 act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th2 act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th1 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Th2 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Primary Tr1 rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CD45RA CD4 lymphocyte act 
                 3.4 
                 4.1 
                 3.0 
               
               
                 CD45RO CD4 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CD8 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
                 0.0 
               
               
                 CD4 lymphocyte none 
                 0.2 
                 0.1 
                 0.0 
               
               
                 2ry Th1/Th2/TM anti-CD95 CH11 
                 0.1 
                 0.0 
                 0.0 
               
               
                 LAK cells rest 
                 0.3 
                 0.0 
                 0.0 
               
               
                 LAK cells IL-2 
                 0.5 
                 0.5 
                 0.0 
               
               
                 LAK cells IL-2 + IL-12 
                 0.0 
                 0.1 
                 0.0 
               
               
                 LAK cells IL-2 + IFN gamma 
                 0.1 
                 0.3 
                 0.0 
               
               
                 LAK cells IL-2 + IL-18 
                 0.5 
                 0.2 
                 0.0 
               
               
                 LAK cells PMA/ionomycin 
                 0.1 
                 0.1 
                 0.0 
               
               
                 NK Cells IL-2 rest 
                 3.3 
                 2.4 
                 2.2 
               
               
                 Two Way MLR 3 day 
                 0.7 
                 0.3 
                 0.0 
               
               
                 Two Way MLR 5 day 
                 0.0 
                 0.1 
                 0.0 
               
               
                 Two Way MLR 7 day 
                 0.0 
                 0.0 
                 0.0 
               
               
                 PBMC rest 
                 0.2 
                 0.2 
                 0.0 
               
               
                 PBMC PWM 
                 0.1 
                 0.0 
                 0.0 
               
               
                 PBMC PHA-L 
                 0.1 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) none 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
                 0.0 
               
               
                 B lymphocytes PWM 
                 0.0 
                 0.0 
                 0.0 
               
               
                 B lymphocytes CD40L and IL-4 
                 0.0 
                 0.2 
                 0.0 
               
               
                 EOL-1 dbcAMP 
                 0.0 
                 0.0 
                 0.0 
               
               
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells none 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells LPS 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Dendritic cells anti-CD40 
                 0.2 
                 0.0 
                 0.0 
               
               
                 Monocytes rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Monocytes LPS 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Macrophages rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Macrophages LPS 
                 0.0 
                 0.0 
                 0.0 
               
               
                 HUVEC none 
                 16.2 
                 17.9 
                 19.5 
               
               
                 HUVEC starved 
                 37.1 
                 38.7 
                 49.0 
               
               
                 HUVEC IL-1beta 
                 21.3 
                 24.5 
                 21.2 
               
               
                 HUVEC IFN gamma 
                 100.0 
                 100.0 
                 100.0 
               
               
                 HUVEC TNF alpha + IFN gamma 
                 10.0 
                 19.2 
                 11.8 
               
               
                 HUVEC TNF alpha + IL4 
                 4.0 
                 5.2 
                 3.1 
               
               
                 HUVEC IL-11 
                 22.5 
                 29.5 
                 28.1 
               
               
                 Lung Microvascular EC none 
                 48.6 
                 91.4 
                 59.5 
               
               
                 Lung Microvascular EC 
                 12.5 
                 18.8 
                 8.6 
               
               
                 TNFalpha + IL-1beta 
               
               
                 Microvascular Dermal EC none 
                 62.9 
                 58.6 
                 62.4 
               
               
                 Microsvasular Dermal EC 
                 8.8 
                 9.9 
                 9.7 
               
               
                 TNFalpha + IL-1beta 
               
               
                 Bronchial epithelium TNFalpha + 
                 3.8 
                 4.2 
                 2.7 
               
               
                 IL1beta 
               
               
                 Small airway epithelium none 
                 1.8 
                 2.1 
                 1.2 
               
               
                 Small airway epithelium 
                 3.4 
                 1.9 
                 2.5 
               
               
                 TNFalpha + IL-1beta 
               
               
                 Coronery artery SMC rest 
                 4.2 
                 3.4 
                 4.4 
               
               
                 Coronery artery SMC TNFalpha + 
                 2.0 
                 3.3 
                 4.1 
               
               
                 IL-1beta 
               
               
                 Astrocytes rest 
                 7.0 
                 6.3 
                 6.0 
               
               
                 Astrocytes TNFalpha + IL-1beta 
                 3.7 
                 4.2 
                 6.5 
               
               
                 KU-812 (Basophil) rest 
                 1.1 
                 1.5 
                 2.0 
               
               
                 KU-812 (Basophil) PMA/ionomycin 
                 4.2 
                 3.9 
                 4.9 
               
               
                 CCD1106 (Keratinocytes) none 
                 1.0 
                 3.0 
                 1.7 
               
               
                 CCD1106 (Keratinocytes) 
                 1.6 
                 1.3 
                 0.0 
               
               
                 TNFalpha + IL-1beta 
               
               
                 Liver cirrhosis 
                 4.5 
                 7.0 
                 6.4 
               
               
                 NCI-H292 none 
                 0.3 
                 0.9 
                 1.1 
               
               
                 NCI-H292 IL-4 
                 0.9 
                 1.3 
                 2.3 
               
               
                 NCI-H292 IL-9 
                 2.0 
                 2.9 
                 2.8 
               
               
                 NCI-H292 IL-13 
                 1.1 
                 1.0 
                 1.5 
               
               
                 NCI-H292 IFN gamma 
                 2.6 
                 2.3 
                 4.2 
               
               
                 HPAEC none 
                 27.0 
                 41.5 
                 52.9 
               
               
                 HPAEC TNF alpha + IL-1 beta 
                 6.0 
                 7.0 
                 4.0 
               
               
                 Lung fibroblast none 
                 10.2 
                 14.4 
                 6.7 
               
               
                 Lung fibroblast TNF alpha + IL-1 
                 11.6 
                 10.8 
                 8.9 
               
               
                 beta 
               
               
                 Lung fibroblast IL-4 
                 9.1 
                 13.9 
                 4.2 
               
               
                 Lung fibroblast IL-9 
                 17.3 
                 26.4 
                 12.2 
               
               
                 Lung fibroblast IL-13 
                 6.3 
                 13.2 
                 5.4 
               
               
                 Lung fibroblast IFN gamma 
                 11.2 
                 9.4 
                 6.6 
               
               
                 Dermal fibroblast CCD1070 rest 
                 11.1 
                 15.9 
                 23.2 
               
               
                 Dermal fibroblast CCD1070 TNF alpha 
                 4.6 
                 6.3 
                 6.3 
               
               
                 Dermal fibroblast CCD1070 IL-1 beta 
                 2.1 
                 3.4 
                 5.9 
               
               
                 Dermal fibroblast IFN gamma 
                 6.9 
                 8.4 
                 4.7 
               
               
                 Dermal fibroblast IL-4 
                 15.5 
                 17.2 
                 21.8 
               
               
                 Dermal Fibroblasts rest 
                 17.6 
                 14.0 
                 12.8 
               
               
                 Neutrophils TNFa + LPS 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Neutrophils rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                 Colon 
                 6.0 
                 5.2 
                 5.5 
               
               
                 Lung 
                 17.1 
                 15.1 
                 25.3 
               
               
                 Thymus 
                 3.6 
                 2.6 
                 5.3 
               
               
                 Kidney 
                 11.4 
                 12.1 
                 14.9 
               
               
                   
               
               
                   Column A - Rel. Exp. (%) Ag1413, Run 169827815    
               
               
                   Column B - Rel. Exp. (%) Ag3819, Run 170127253    
               
               
                   Column C - Rel. Exp. (%) Ag740, Run 169827863    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BFI 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Th2 act 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Tr1 act 
                 0.0 
                 0.2 
               
               
                   
                 Secondary Th1 rest 
                 0.1 
                 0.0 
               
               
                   
                 Secondary Th2 rest 
                 0.0 
                 0.0 
               
               
                   
                 Secondary Tr1 rest 
                 0.0 
                 0.2 
               
               
                   
                 Primary Th1 act 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th2 act 
                 0.0 
                 0.0 
               
               
                   
                 Primary Tr1 act 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th1 rest 
                 0.0 
                 0.0 
               
               
                   
                 Primary Th2 rest 
                 0.0 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 0.0 
                 0.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 3.8 
                 4.6 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 0.0 
                 0.3 
               
               
                   
                 CD8 lymphocyte act 
                 0.1 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 0.0 
                 0.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 0.0 
                 0.0 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
                 0.0 
               
               
                   
                 2ry Th1/Th2/Tr1_anti-CD95 CH11 
                 0.1 
                 0.0 
               
               
                   
                 LAK cells rest 
                 0.3 
                 0.1 
               
               
                   
                 LAK cells IL-2 
                 0.5 
                 0.4 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 0.3 
                 0.2 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 0.4 
                 0.4 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.5 
                 0.0 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.0 
                 0.4 
               
               
                   
                 NK Cells IL-2 rest 
                 2.2 
                 1.8 
               
               
                   
                 Two Way MLR 3 day 
                 0.4 
                 0.5 
               
               
                   
                 Two Way MLR 5 day 
                 0.1 
                 0.1 
               
               
                   
                 Two Way MLR 7 day 
                 0.1 
                 0.0 
               
               
                   
                 PBMC rest 
                 0.4 
                 0.6 
               
               
                   
                 PBMC PWM 
                 0.4 
                 0.0 
               
               
                   
                 PBMC PHA-L 
                 0.1 
                 0.1 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 0.1 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
                 0.0 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 0.0 
                 0.0 
               
               
                   
                 Dendritic cells LPS 
                 0.0 
                 0.0 
               
               
                   
                 Dendritic cells anti-CD40 
                 0.0 
                 0.0 
               
               
                   
                 Monocytes rest 
                 0.0 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 0.0 
                 0.0 
               
               
                   
                 Macrophages rest 
                 0.0 
                 0.1 
               
               
                   
                 Macrophages LPS 
                 0.0 
                 0.0 
               
               
                   
                 HUVEC none 
                 22.8 
                 30.4 
               
               
                   
                 HUVEC starved 
                 97.9 
                 88.9 
               
               
                   
                 HUVEC IL-1 beta 
                 17.8 
                 8.5 
               
               
                   
                 HUVEC IFN gamma 
                 100.0 
                 100.0 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 18.2 
                 16.2 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 5.4 
                 4.2 
               
               
                   
                 HUVEC IL-11 
                 31.4 
                 35.1 
               
               
                   
                 Lung Microvascular EC none 
                 50.3 
                 50.7 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL- 
                 9.0 
                 6.8 
               
               
                   
                 1beta 
               
               
                   
                 Microvascular Dermal EC none 
                 71.7 
                 83.5 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL- 
                 16.2 
                 14.1 
               
               
                   
                 1beta 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 6.7 
                 5.6 
               
               
                   
                 Small airway epithelium none 
                 2.0 
                 2.1 
               
               
                   
                 Small airway epithelium TNFalpha + IL- 
                 12.9 
                 8.8 
               
               
                   
                 1beta 
               
               
                   
                 Coronery artery SMC rest 
                 5.4 
                 4.8 
               
               
                   
                 Coronery artery SMC TNFalpha + IL- 
                 2.2 
                 2.6 
               
               
                   
                 1beta 
               
               
                   
                 Astrocytes rest 
                 5.1 
                 8.9 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 5.8 
                 5.8 
               
               
                   
                 KU-812 (Basophil) rest 
                 1.2 
                 0.7 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 6.7 
                 4.7 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 2.0 
                 4.4 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL- 
                 1.1 
                 0.7 
               
               
                   
                 1beta 
               
               
                   
                 Liver cirrhosis 
                 4.8 
                 4.9 
               
               
                   
                 Lupus kidney 
                 1.9 
                 4.7 
               
               
                   
                 NCI-H292 none 
                 2.1 
                 1.5 
               
               
                   
                 NCI-H292 IL-4 
                 3.1 
                 2.3 
               
               
                   
                 NCI-H292 IL-9 
                 3.7 
                 3.1 
               
               
                   
                 NCI-H292 IL-13 
                 1.5 
                 1.7 
               
               
                   
                 NCI-H292 IFN gamma 
                 3.6 
                 1.6 
               
               
                   
                 HPAEC none 
                 29.3 
                 40.1 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 4.5 
                 5.3 
               
               
                   
                 Lung fibroblast none 
                 12.7 
                 19.1 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 10.0 
                 15.3 
               
               
                   
                 Lung fibroblast IL-4 
                 16.4 
                 20.2 
               
               
                   
                 Lung fibroblast IL-9 
                 19.1 
                 21.5 
               
               
                   
                 Lung fibroblast IL-13 
                 7.5 
                 14.5 
               
               
                   
                 Lung fibroblast IFN gamma 
                 17.2 
                 19.6 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 30.6 
                 27.0 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 8.4 
                 10.1 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 6.5 
                 8.5 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 7.0 
                 11.0 
               
               
                   
                 Dermal fibroblast IL-4 
                 17.6 
                 15.7 
               
               
                   
                 IBD Colitis 2 
                 0.5 
                 2.2 
               
               
                   
                 IBD Crohn&#39;s 
                 1.8 
                 3.0 
               
               
                   
                 Colon 
                 14.6 
                 15.6 
               
               
                   
                 Lung 
                 17.9 
                 21.0 
               
               
                   
                 Thymus 
                 22.1 
                 22.2 
               
               
                   
                 Kidney 
                 6.7 
                 5.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1515, Run 163478545    
               
               
                   
                   Column B - Rel. Exp. (%) Ag3085, Run 164682194    
               
            
           
         
       
     
      General_screening_panel_v1.4 Summary: Ag1413/Ag3819 Highest expression of this gene was seen in a lung cancer cell line NCI-H23 sample (CT=26-28). High to moderate levels of expression of this gene were also seen in a cluster of CNS cancer, renal cancer, lung cancer, breast cancer, ovarian cancer and melanoma cell lines. Therefore, therapeutic modulation of the activity of this gene or its protein product, through the use of small molecule drugs, protein therapeutics or antibodies, is beneficial in the treatment of lung cancer or ovarian cancer. This gene encodes a cadherin-related tumor suppressor precursor. E-cadherin, a related protein is used as a prognostic marker for breast cancer detection (Barshack I, J Clin Pathol 54(9):684-8). Expression of this gene is useful as a diagnostic marker in the above mentioned cancers.  
      Among tissues with metabolic or endocrine function, this gene was expressed at high to moderate levels in pancreas, adipose, adrenal gland, thyroid, pituitary gland, skeletal muscle, heart, liver and the gastrointestinal tract. Therapeutic modulation of the activity of this gene is useful in the treatment of endocrine/metabolically related diseases, such as obesity and diabetes. In addition, E cadherin, a related protein is shown to be reduced in small intestinal mucosa of coeliac sprue disease (Barshak et. al), a sample not used in this panel. Therapeutic modulation of the activity or function of this gene or gene product is useful in the treatment of coelic sprue disease.  
      In addition, this gene was expressed at low to moderate levels in all regions of the central nervous system examined, including amygdala, hippocampus, substantia nigra, thalamus, cerebellum, cerebral cortex, and spinal cord. This gene product is a transmembrane glycoproteins belonging to the cadherin superfamily of molecules, which are involved in many biological processes such as cell adhesion, cytoskeletal organization and morphogenesis. Cadherins can act as axon guidance and cell adhesion proteins, specifically during development and in the response to injury (Ranscht B. Int. J. Dev. Neurosci. 18: 643-651.). Therefore, manipulation of levels of this protein are of use in inducing a compensatory synaptogenic response to neuronal death in Alzheimer&#39;s disease, Parkinson&#39;s disease, Huntington&#39;s disease, spinocerebellar ataxia, progressive supranuclear palsy, ALS, head trauma, stroke, or any other disease/condition associated with neuronal loss.  
      Panel 2D Summary: Ag1413/Ag740 Highest expression of this gene wass detected in samples from normal kidney and colon (CTs=29-30), with significant expression of this gene in both normal and cancer tissues. Expression of this gene was higher in control margin samples of colon (ODO3920), liver (OD04310), and ovary (OD04768-08) as compared to their corresponding cancer tissue. Please see Panel 1.4 for a discussion of the potential utility of this gene.  
      Panel 4.1D Summary: Ag1413/Ag3819/Ag740 Highest expression of this gene was detected in IFN gamma treated HUVEC cells (CTs=25-27). High to moderate expression of this gene was seen in treated and untreated HUVEC, lung microvascular EC, microvascular dermal EC, Bronchial epithelium, small airway epithelium, NCI-H292, HPAEC, lung fibroblasts, and dermal fibroblasts. The expression of this gene in cells derived from or within the lung shows that this gene is involved in normal conditions as well as pathological and inflammatory lung disorders that include chronic obstructive pulmonary disease, asthma, allergy and emphysema.  
      In addition, high expression of thisgene was also detected in normal tissues represented by colon, lung, thymus and kidney. Therapeutic modulation of the activity of the protein encoded by this gene is useful in the treatment of inflammatory disease affecting these tissues such as inflammatory bowel disease, chronic obstructive pulmonary disease, asthma, allergy, emphysema, lupus and glomerulonephritis.  
      Panel 4D Summary: Ag1515/Ag3085 Highest expression of this gene was detected in IFN gamma treated HUVEC cells (CT=25-27). In addition, high to moderate expression of this gene was seen in treated and untreated HVEC, lung microvascular EC, microvascular dermal EC, Bronchial epithelium, small airway epithelium, NCI-H292, HPAEC, lung fibroblasts, and dermal fibroblasts. The expression of this gene in cells derived from or within the lung shows that this gene is involved in normal conditions as well as pathological and inflammatory lung disorders that include chronic obstructive pulmonary disease, asthma, allergy and emphysema.  
      Expression of this gene was higher in untreated HPAEC (CTs=27-28) as compared to TNF alpha+IL-1 beta treated cells (CTs=30-31). Thus, expression of this gene is useful as a marker to distinguish the treated from untreated HIPAEC samples.  
      In addition, high levels of expression of this gene were also detected in normal tissues represented by colon, lung, thymus and kidney. Expression of this gene is lower in colon samples from patients with IBD colitis and Crohn&#39;s disease relative CTs=31-33) to normal colon (CTs=28-29). Therefore, therapeutic modulation of the activity or function of this gene or the protein encoded by this gene is useful in the treatment of inflammatory bowel disease.  
      BG. CG93387-05: Fibropellin I Precursor  
      Expression of gene CG93387-05 was assessed using the primer-probe sets Agl 143, Ag1921, and Ag3082, described in Tables BGA, BGB, and BGC. Results of the RTQ-PCR runs are shown in Tables BGD, BGE, and BGF.  
               TABLE BGA                          Probe Name Ag1143                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No                                             Forward   5′-gagatggatgtggacgactg-3′   20   964   1573                   Probe   TET-5′-cctgaatggaggctcttgtgttgacc-3′-   26   999   1574           TAMRA               Reverse   5′-acaagcaggtgtaattcccc-3′   20   1029   1575                  
 
     
       
         
           
               
             
               
                 TABLE BGB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag1921 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-acacattccagactgtgctcat-3′ 
                 22 
                 317 
                 1576 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-acggcaagctctccttcaccatctt-3′- 
                 25 
                 344 
                 1577 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-tccacacgatggactcatagtt-3′ 
                 22 
                 370 
                 1578 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BGC 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag3082 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-cagacgcagaggtagctcc-3′ 
                 19 
                 1385 
                 1579 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-catctgggcactgtgtgttcatgttg-3′- 
                 26 
                 1335 
                 1580 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-atttgaaatcacagccatgc-3′ 
                 20 
                 1311 
                 1581 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BGD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 31.2 
               
               
                   
                 Pancreas 
                 2.5 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.2 
               
               
                   
                 Adrenal gland 
                 12.3 
               
               
                   
                 Thyroid 
                 19.5 
               
               
                   
                 Salivary gland 
                 2.3 
               
               
                   
                 Pituitary gland 
                 10.2 
               
               
                   
                 Brain (fetal) 
                 2.1 
               
               
                   
                 Brain (whole) 
                 10.8 
               
               
                   
                 Brain (amygdala) 
                 12.3 
               
               
                   
                 Brain (cerebellum) 
                 21.0 
               
               
                   
                 Brain (hippocampus) 
                 21.8 
               
               
                   
                 Brain (substantia nigra) 
                 3.9 
               
               
                   
                 Brain (thalamus) 
                 8.7 
               
               
                   
                 Cerebral Cortex 
                 8.7 
               
               
                   
                 Spinal cord 
                 12.8 
               
               
                   
                 glio/astro U87-MG 
                 3.0 
               
               
                   
                 glio/astro U-118-MG 
                 100.0 
               
               
                   
                 astrocytoma SW1783 
                 6.9 
               
               
                   
                 neuro*; met SK-N-AS 
                 3.1 
               
               
                   
                 astrocytoma SF-539 
                 12.6 
               
               
                   
                 astrocytoma SNB-75 
                 25.9 
               
               
                   
                 glioma SNB-19 
                 8.9 
               
               
                   
                 glioma U251 
                 4.9 
               
               
                   
                 glioma SF-295 
                 33.7 
               
               
                   
                 Heart (Fetal) 
                 1.6 
               
               
                   
                 Heart 
                 5.8 
               
               
                   
                 Skeletal muscle (Fetal) 
                 5.8 
               
               
                   
                 Skeletal muscle 
                 14.3 
               
               
                   
                 Bone marrow 
                 1.0 
               
               
                   
                 Thymus 
                 5.1 
               
               
                   
                 Spleen 
                 22.5 
               
               
                   
                 Lymph node 
                 28.5 
               
               
                   
                 Colorectal 
                 3.6 
               
               
                   
                 Stomach 
                 11.8 
               
               
                   
                 Small intestine 
                 14.5 
               
               
                   
                 Colon ca. SW480 
                 0.8 
               
               
                   
                 Colon ca.* SW620 (SW480 met) 
                 0.3 
               
               
                   
                 Colon ca. HT29 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 1.1 
               
               
                   
                 Colon ca. CaCo-2 
                 0.0 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 3.1 
               
               
                   
                 Colon ca. HCC-2998 
                 0.4 
               
               
                   
                 Gastric ca. (liver met) NCI-N87 
                 3.5 
               
               
                   
                 Bladder 
                 8.8 
               
               
                   
                 Trachea 
                 7.5 
               
               
                   
                 Kidney 
                 3.5 
               
               
                   
                 Kidney (fetal) 
                 3.4 
               
               
                   
                 Renal ca. 786-0 
                 0.2 
               
               
                   
                 Renal ca. A498 
                 12.4 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.2 
               
               
                   
                 Renal ca. TK-10 
                 0.1 
               
               
                   
                 Liver 
                 2.4 
               
               
                   
                 Liver (fetal) 
                 1.6 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.0 
               
               
                   
                 Lung 
                 9.0 
               
               
                   
                 Lung (fetal) 
                 6.4 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 2.9 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.3 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 4.0 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 4.4 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 1.3 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 2.9 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 2.7 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 6.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.8 
               
               
                   
                 Mammary gland 
                 12.5 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.3 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 1.7 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 1.0 
               
               
                   
                 Breast ca. BT-549 
                 15.1 
               
               
                   
                 Breast ca. MDA-N 
                 0.5 
               
               
                   
                 Ovary 
                 13.4 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 1.1 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 12.2 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.5 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 7.2 
               
               
                   
                 Uterus 
                 32.8 
               
               
                   
                 Placenta 
                 1.1 
               
               
                   
                 Prostate 
                 12.4 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
               
               
                   
                 Testis 
                 8.1 
               
               
                   
                 Melanoma Hs688(A).T 
                 2.6 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.9 
               
               
                   
                 Melanoma UACC-62 
                 4.8 
               
               
                   
                 Melanoma M14 
                 17.8 
               
               
                   
                 Melanoma LOX IMVI 
                 0.2 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.2 
               
               
                   
                 Adipose 
                 17.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3082, Run 165673172    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BGE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2.2 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 20.3 
               
               
                   
                 Colon cancer (OD06064) 
                 8.5 
               
               
                   
                 Colon Margin (OD06064) 
                 6.4 
               
               
                   
                 Colon cancer (OD06159) 
                 1.4 
               
               
                   
                 Colon Margin (OD06159) 
                 9.6 
               
               
                   
                 Colon cancer (OD06297-04) 
                 1.1 
               
               
                   
                 Colon Margin (OD06297-05) 
                 5.7 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 5.9 
               
               
                   
                 CC Margin (ODO3921) 
                 2.9 
               
               
                   
                 Colon cancer metastasis (OD06104) 
                 1.3 
               
               
                   
                 Lung Margin (OD06104) 
                 0.8 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 17.3 
               
               
                   
                 Lung Margin (OD04451-02) 
                 17.2 
               
               
                   
                 Normal Prostate 
                 20.3 
               
               
                   
                 Prostate Cancer (OD04410) 
                 13.1 
               
               
                   
                 Prostate Margin (OD04410) 
                 10.1 
               
               
                   
                 Normal Ovary 
                 52.5 
               
               
                   
                 Ovarian cancer (OD06283-03) 
                 8.6 
               
               
                   
                 Ovarian Margin (OD06283-07) 
                 13.1 
               
               
                   
                 Ovarian Cancer 
                 23.2 
               
               
                   
                 Ovarian cancer (OD06145) 
                 6.4 
               
               
                   
                 Ovarian Margin (OD06145) 
                 52.5 
               
               
                   
                 Ovarian cancer (OD06455-03) 
                 13.6 
               
               
                   
                 Ovarian Margin (OD06455-07) 
                 33.2 
               
               
                   
                 Normal Lung 
                 19.6 
               
               
                   
                 Invasive poor diff. lung adeno (ODO4945-01 
                 7.7 
               
               
                   
                 Lung Margin (ODO4945-03) 
                 48.3 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 11.0 
               
               
                   
                 Lung Margin (OD03126) 
                 6.5 
               
               
                   
                 Lung Cancer (OD05014A) 
                 11.8 
               
               
                   
                 Lung Margin (OD05014B) 
                 49.0 
               
               
                   
                 Lung cancer (OD06081) 
                 17.6 
               
               
                   
                 Lung Margin (OD06081) 
                 37.9 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 1.2 
               
               
                   
                 Lung Margin (OD04237-02) 
                 23.7 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 44.1 
               
               
                   
                 Liver Margin (ODO4310) 
                 14.9 
               
               
                   
                 Melanoma Metastasis 
                 0.0 
               
               
                   
                 Lung Margin (OD04321) 
                 16.3 
               
               
                   
                 Normal Kidney 
                 9.8 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 26.6 
               
               
                   
                 Kidney Margin (OD04338) 
                 1.6 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 20.2 
               
               
                   
                 Kidney Margin (OD04339) 
                 10.2 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 20.9 
               
               
                   
                 Kidney Margin (OD04340) 
                 13.3 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 4.4 
               
               
                   
                 Kidney Margin (OD04348) 
                 54.0 
               
               
                   
                 Kidney malignant cancer (OD06204B) 
                 0.6 
               
               
                   
                 Kidney normal adjacent tissue (OD06204E) 
                 8.5 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 0.5 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 16.4 
               
               
                   
                 Kidney Cancer 8120613 
                 0.0 
               
               
                   
                 Kidney Margin 8120614 
                 11.0 
               
               
                   
                 Kidney Cancer 9010320 
                 1.5 
               
               
                   
                 Kidney Margin 9010321 
                 7.1 
               
               
                   
                 Kidney Cancer 8120607 
                 6.3 
               
               
                   
                 Kidney Margin 8120608 
                 5.9 
               
               
                   
                 Normal Uterus 
                 52.1 
               
               
                   
                 Uterine Cancer 064011 
                 37.6 
               
               
                   
                 Normal Thyroid 
                 10.2 
               
               
                   
                 Thyroid Cancer 
                 4.0 
               
               
                   
                 Thyroid Cancer A302152 
                 21.0 
               
               
                   
                 Thyroid Margin A302153 
                 29.5 
               
               
                   
                 Normal Breast 
                 52.1 
               
               
                   
                 Breast Cancer 
                 2.7 
               
               
                   
                 Breast Cancer 
                 43.5 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 59.5 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 35.4 
               
               
                   
                 Breast Cancer Metastasis 
                 44.1 
               
               
                   
                 Breast Cancer 
                 17.9 
               
               
                   
                 Breast Cancer 9100266 
                 16.6 
               
               
                   
                 Breast Margin 9100265 
                 26.1 
               
               
                   
                 Breast Cancer A209073 
                 9.8 
               
               
                   
                 Breast Margin A209073 
                 28.3 
               
               
                   
                 Breast cancer (OD06083) 
                 63.7 
               
               
                   
                 Breast cancer node metastasis (OD06083) 
                 100.0 
               
               
                   
                 Normal Liver 
                 39.8 
               
               
                   
                 Liver Cancer 1026 
                 17.2 
               
               
                   
                 Liver Cancer 1025 
                 40.3 
               
               
                   
                 Liver Cancer 6004-T 
                 33.7 
               
               
                   
                 Liver Tissue 6004-N 
                 2.2 
               
               
                   
                 Liver Cancer 6005-T 
                 42.3 
               
               
                   
                 Liver Tissue 6005-N 
                 44.8 
               
               
                   
                 Liver Cancer 
                 4.2 
               
               
                   
                 Normal Bladder 
                 17.6 
               
               
                   
                 Bladder Cancer 
                 8.4 
               
               
                   
                 Bladder Cancer 
                 3.2 
               
               
                   
                 Normal Stomach 
                 25.2 
               
               
                   
                 Gastric Cancer 9060397 
                 0.7 
               
               
                   
                 Stomach Margin 9060396 
                 4.7 
               
               
                   
                 Gastric Cancer 9060395 
                 8.1 
               
               
                   
                 Stomach Margin 9060394 
                 12.2 
               
               
                   
                 Gastric Cancer 064005 
                 7.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3082, Run 174284798    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BGF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
                 C 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Secondary Th1 act 
                 1.3 
                 0.0 
                 1.4 
               
               
                   
                 Secondary Th2 act 
                 6.3 
                 0.5 
                 5.8 
               
               
                   
                 Secondary Tr1 act 
                 5.5 
                 0.7 
                 3.8 
               
               
                   
                 Secondary Th1 rest 
                 6.3 
                 1.9 
                 12.8 
               
               
                   
                 Secondary Th2 rest 
                 17.0 
                 2.0 
                 19.2 
               
               
                   
                 Secondary Tr1 rest 
                 12.9 
                 0.8 
                 18.8 
               
               
                   
                 Primary Th1 act 
                 0.9 
                 0.0 
                 0.8 
               
               
                   
                 Primary Th2 act 
                 0.7 
                 0.0 
                 2.3 
               
               
                   
                 Primary Tr1 act 
                 1.5 
                 0.1 
                 2.3 
               
               
                   
                 Primary Th1 rest 
                 21.0 
                 5.8 
                 50.7 
               
               
                   
                 Primary Th2 rest 
                 32.5 
                 7.5 
                 0.0 
               
               
                   
                 Primary Tr1 rest 
                 2.3 
                 0.3 
                 6.3 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 2.5 
                 1.4 
                 2.3 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 2.7 
                 1.1 
                 1.8 
               
               
                   
                 CD8 lymphocyte act 
                 2.1 
                 0.6 
                 2.9 
               
               
                   
                 Secondary CD8 
                 2.9 
                 0.5 
                 4.2 
               
               
                   
                 lymphocyte rest 
               
               
                   
                 Secondary CD8 
                 5.4 
                 0.0 
                 3.1 
               
               
                   
                 lymphocyte act 
               
               
                   
                 CD4 lymphocyte none 
                 11.7 
                 3.7 
                 10.8 
               
               
                   
                 2ry Th1/Th2/Tr1 anti- 
                 27.5 
                 1.3 
                 27.0 
               
               
                   
                 CD95 CH11 
               
               
                   
                 LAK cells rest 
                 4.5 
                 1.1 
                 4.4 
               
               
                   
                 LAK cells IL-2 
                 6.8 
                 3.7 
                 11.3 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 1.8 
                 0.3 
                 2.8 
               
               
                   
                 LAK cells IL-2 + IFN 
                 3.2 
                 1.1 
                 6.4 
               
               
                   
                 gamma 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 1.7 
                 0.5 
                 7.6 
               
               
                   
                 LAK cells PMA/ionomycin 
                 1.6 
                 0.1 
                 1.1 
               
               
                   
                 NK Cells IL-2 rest 
                 2.2 
                 0.8 
                 3.2 
               
               
                   
                 Two Way MLR 3 day 
                 5.6 
                 2.3 
                 6.0 
               
               
                   
                 Two Way MLR 5 day 
                 1.1 
                 0.4 
                 1.4 
               
               
                   
                 Two Way MLR 7 day 
                 0.9 
                 0.5 
                 1.4 
               
               
                   
                 PBMC rest 
                 7.1 
                 1.7 
                 4.6 
               
               
                   
                 PBMC PWM 
                 0.9 
                 1.0 
                 3.8 
               
               
                   
                 PBMC PHA-L 
                 3.0 
                 0.4 
                 2.6 
               
               
                   
                 Ramos (B cell) none 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.0 
                 0.0 
                 0.2 
               
               
                   
                 B lymphocytes PWM 
                 5.3 
                 2.0 
                 22.8 
               
               
                   
                 B lymphocytes CD40L 
                 18.0 
                 3.6 
                 57.8 
               
               
                   
                 and IL-4 
               
               
                   
                 EOL-1 dbcAMP 
                 0.0 
                 0.1 
                 0.2 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 Dendritic cells none 
                 3.3 
                 4.2 
                 5.1 
               
               
                   
                 Dendritic cells LPS 
                 0.8 
                 1.5 
                 1.3 
               
               
                   
                 Dendritic cells anti-CD40 
                 4.3 
                 4.6 
                 5.4 
               
               
                   
                 Monocytes rest 
                 2.4 
                 8.6 
                 6.3 
               
               
                   
                 Monocytes LPS 
                 0.0 
                 0.2 
                 1.0 
               
               
                   
                 Macrophages rest 
                 1.8 
                 2.9 
                 1.7 
               
               
                   
                 Macrophages LPS 
                 0.7 
                 0.5 
                 0.5 
               
               
                   
                 HUVEC none 
                 6.2 
                 12.1 
                 10.4 
               
               
                   
                 HUVEC starved 
                 4.4 
                 11.9 
                 12.9 
               
               
                   
                 HUVEC IL-1beta 
                 0.9 
                 1.6 
                 3.3 
               
               
                   
                 HUVEC IFN gamma 
                 23.0 
                 13.6 
                 13.6 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 2.1 
                 3.5 
                 7.5 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 6.2 
                 4.2 
                 3.2 
               
               
                   
                 HUVEC IL-11 
                 12.1 
                 8.7 
                 8.1 
               
               
                   
                 Lung Microvascular EC none 
                 27.7 
                 24.3 
                 21.5 
               
               
                   
                 Lung Microvascular EC TNFalpha + 
                 8.7 
                 14.5 
                 16.6 
               
               
                   
                 IL-1beta 
               
               
                   
                 Microvascular Dermal EC none 
                 19.5 
                 19.3 
                 20.3 
               
               
                   
                 Microsvasular Dermal EC 
                 10.1 
                 11.3 
                 10.3 
               
               
                   
                 TNFalpha + IL-1beta 
               
               
                   
                 Bronchial epithelium TNFalpha + 
                 0.3 
                 0.4 
                 1.0 
               
               
                   
                 IL1beta 
               
               
                   
                 Small airway epithelium none 
                 2.0 
                 4.9 
                 2.6 
               
               
                   
                 Small airway epithelium TNFalpha + 
                 0.7 
                 0.2 
                 2.1 
               
               
                   
                 IL-1beta 
               
               
                   
                 Coronery artery SMC rest 
                 0.7 
                 3.6 
                 2.9 
               
               
                   
                 Coronery artery SMC TNFalpha + 
                 6.7 
                 1.4 
                 3.7 
               
               
                   
                 IL-1beta 
               
               
                   
                 Astrocytes rest 
                 3.7 
                 3.0 
                 3.7 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 3.7 
                 3.4 
                 4.0 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.0 
                 0.0 
                 0.0 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.0 
                 0.1 
                 0.1 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
                 0.0 
                 0.1 
               
               
                   
                 93580 CCD1106 (Keratinocytes) 
                 0.0 
                 0.0 
                 0.2 
               
               
                   
                 TNFa and IFNg 
               
               
                   
                 Liver cirrhosis 
                 3.5 
                 4.5 
                 5.9 
               
               
                   
                 Lupus kidney 
                 15.0 
                 6.1 
                 10.2 
               
               
                   
                 NCI-H292 none 
                 0.4 
                 1.6 
                 3.5 
               
               
                   
                 NCI-H292 IL-4 
                 0.6 
                 1.3 
                 3.4 
               
               
                   
                 NCI-H292 IL-9 
                 1.0 
                 2.2 
                 3.0 
               
               
                   
                 NCI-H292 IL-13 
                 3.5 
                 0.4 
                 0.8 
               
               
                   
                 NCI-H292 IFN gamma 
                 2.3 
                 1.0 
                 1.3 
               
               
                   
                 HPAEC none 
                 58.6 
                 32.5 
                 32.1 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 18.6 
                 16.8 
                 22.4 
               
               
                   
                 Lung fibroblast none 
                 78.5 
                 79.6 
                 90.1 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 
                 20.0 
                 18.0 
                 24.0 
               
               
                   
                 beta 
               
               
                   
                 Lung fibroblast IL-4 
                 48.3 
                 100.0 
                 100.0 
               
               
                   
                 Lung fibroblast IL-9 
                 35.4 
                 56.6 
                 49.7 
               
               
                   
                 Lung fibroblast IL-13 
                 100.0 
                 64.2 
                 77.4 
               
               
                   
                 Lung fibroblast IFN gamma 
                 56.6 
                 96.6 
                 82.4 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 5.7 
                 9.3 
                 17.2 
               
               
                   
                 Dermal fibroblast CCD1070 TNF 
                 11.3 
                 6.0 
                 25.5 
               
               
                   
                 alpha 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 
                 20.3 
                 4.0 
                 6.5 
               
               
                   
                 beta 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 30.8 
                 9.2 
                 18.7 
               
               
                   
                 Dermal fibroblast IL-4 
                 35.1 
                 17.8 
                 26.4 
               
               
                   
                 IBD Colitis 2 
                 4.1 
                 2.8 
                 5.5 
               
               
                   
                 IBD Crohn&#39;s 
                 1.7 
                 1.4 
                 2.2 
               
               
                   
                 Colon 
                 6.2 
                 7.4 
                 8.5 
               
               
                   
                 Lung 
                 13.9 
                 19.1 
                 20.3 
               
               
                   
                 Thymus 
                 25.2 
                 16.4 
                 14.7 
               
               
                   
                 Kidney 
                 13.8 
                 8.6 
                 31.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1143, Run 139943479    
               
               
                   
                   Column B - Rel. Exp. (%) Ag1921, Run 164629443    
               
               
                   
                   Column C - Rel. Exp. (%) Ag3082, Run 164681898    
               
            
           
         
       
     
      Panel 1.3D Summary: Ag3082 Highest expression of this gene was seen in a brain cancer cell line (CT=27.3). Significant levels of expression were also seen in a cluster of samples derived from ovarian, breast, melanoma and brain cancer cell lines. Thus, expression of this gene is useful as a marker to differentiate between the brain cancer samples and other samples on this panel and as a marker to detect the presence of these cancers. This gene encodes a protein that is homologous to an epidermal growth factor related protein (fibropellin like). Fibropellins are a family of extracellular sea urchin matrix proteins that have been implicated in cell adhestion. Therefore, therapeutic modulation of the expression or function of this gene is useful in the treatment of ovarian, breast, melanoma and brain cancers.  
      Among tissues with metabolic function, this gene was expressed at moderate to low levels in pituitary, adipose, adrenal gland, pancreas, thyroid, and adult and fetal skeletal muscle, heart, and liver. This widespread expression among these tissues shows that this gene product plays a role in normal neuroendocrine and metabolic and that disregulated expression of this gene contributes to neuroendocrine disorders or metabolic diseases, such as obesity and diabetes.  
      Moderate to low levels of expression were also seen in all regions of the CNS examined, including pituitary, amygdala, thalamus, substantia nigra, cerebral cortex, and hippocampus. Therefore, therapeutic modulation of the expression or function of this gene is useful in the treatment of neurologic disorders, such as Alzheimer&#39;s disease, Parkinson&#39;s disease, schizophrenia, multiple sclerosis, stroke and epilepsy.  
      Panel 2.2 Summary: Ag3082 Highest expression of this gene was seen in a breast cancer metastasis (CT=28.3). Significant levels of expression were also seen in a cluster of breast cancer samples. Conversely, expression was higher in normal ovary and lung tissue when compared to expression in the normal adjacent tissue. Thus, therapeutic modulation of the expression or function of this gene is effective in the treatment of breast, ovarian and lung cancers.  
      Panel 4D Summary: Agl 143/Ag1921/Ag3082 Highest expression of this gene was detected in treated lung fibroblasts (CTs=27-29). Moderate levels of expression were also seen in treated dermal fibroblasts, and lung and dermal microvasculature, and HUVECs. Thus, expression of this gene is useful as a marker of fibroblasts or vasculature. The protein encoded by the transcript plays an important role in the normal homeostasis of these tissues. Therefore, therapeutics designed with this gene or gene product are important for maintaining or restoring normal function to these organs during inflammation associated with asthma, psoriasis, and emphysema.  
      BH. CG93871-01 and CG93871-05: Weakly Similar to Fibulin-1  
      Expression of gene CG93871-05 and variant CG93871-01 was assessed using the primer-probe sets Ag1294b, Ag746, and Ag4726, described in Tables BHA, BHB, and BHC. Results of the RTQ-PCR runs are shown in Tables BHD, BHE, BHF, BHG, and BHH. Please note that the probe and primer set Ag4726 is specific to the CG93871-05 variant only.  
               TABLE BHA                          Probe Name Ag1294b                                                     SEQ                       Start   ID       Primers   Sequences   Length   Position   No               Forward   5′-cattggcagctacaagtgttc-3′   21   532   1582                   Probe   TET-5′-ctgtcgaactggcttccaccttcat-3′-   25   553   1583           TAMRA               Reverse   5′-cctccgacactcgtttacatc-3′   21   599   1584                  
 
     
       
         
           
               
             
               
                 TABLE BHB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag746 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-gcattggcagctacaagtgt-3′ 
                 20 
                 531 
                 1585 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-ctgtcgaactggcttccaccttcat-3′- 
                 25 
                 553 
                 1586 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-cctccgacactcgtttacatc-3′ 
                 21 
                 599 
                 1587 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BHC 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag4726 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-gtgtctgtctggctggaaac-3′ 
                 20 
                 1338 
                 1588 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-tgcatctctcctgagtgtccttctgg-3′- 
                 26 
                 1364 
                 1589 
               
               
                   
                 TAMRA 
               
               
                   
               
               
                 Reverse 
                 5′-acaagtacagcaatccgtctgt-3′ 
                 22 
                 1408 
                 1590 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BHD 
               
             
            
               
                   
               
               
                   
               
               
                 AI_comprehensive panel_v1.0 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 110967 COPD-F 
                 6.6 
               
               
                   
                 110980 COPD-F 
                 16.6 
               
               
                   
                 110968 COPD-M 
                 3.9 
               
               
                   
                 110977 COPD-M 
                 31.6 
               
               
                   
                 110989 Emphysema-F 
                 45.1 
               
               
                   
                 110992 Emphysema-F 
                 7.2 
               
               
                   
                 110993 Emphysema-F 
                 5.8 
               
               
                   
                 110994 Emphysema-F 
                 3.3 
               
               
                   
                 110995 Emphysema-F 
                 2.0 
               
               
                   
                 110996 Emphysema-F 
                 3.1 
               
               
                   
                 110997 Asthma-M 
                 3.7 
               
               
                   
                 111001 Asthma-F 
                 2.8 
               
               
                   
                 111002 Asthma-F 
                 5.3 
               
               
                   
                 111003 Atopic Asthma-F 
                 6.1 
               
               
                   
                 111004 Atopic Asthma-F 
                 3.4 
               
               
                   
                 111005 Atopic Asthma-F 
                 3.9 
               
               
                   
                 111006 Atopic Asthma-F 
                 2.4 
               
               
                   
                 111417 Allergy-M 
                 6.6 
               
               
                   
                 112347 Allergy-M 
                 3.3 
               
               
                   
                 112349 Normal Lung-F 
                 3.2 
               
               
                   
                 112357 Normal Lung-F 
                 100.0 
               
               
                   
                 112354 Normal Lung-M 
                 58.6 
               
               
                   
                 112374 Crohns-F 
                 7.5 
               
               
                   
                 112389 Match Control Crohns-F 
                 3.5 
               
               
                   
                 112375 Crohns-F 
                 5.1 
               
               
                   
                 112732 Match Control Crohns-F 
                 0.5 
               
               
                   
                 112725 Crohns-M 
                 10.6 
               
               
                   
                 112387 Match Control Crohns-M 
                 3.5 
               
               
                   
                 112378 Crohns-M 
                 1.7 
               
               
                   
                 112390 Match Control Crohns-M 
                 55.5 
               
               
                   
                 112726 Crohns-M 
                 3.6 
               
               
                   
                 112731 Match Control Crohns-M 
                 13.9 
               
               
                   
                 112380 Ulcer Col-F 
                 13.7 
               
               
                   
                 112734 Match Control Ulcer Col-F 
                 5.6 
               
               
                   
                 112384 Ulcer Col-F 
                 3.9 
               
               
                   
                 112737 Match Control Ulcer Col-F 
                 3.3 
               
               
                   
                 112386 Ulcer Col-F 
                 0.0 
               
               
                   
                 112738 Match Control Ulcer Col-F 
                 0.0 
               
               
                   
                 112381 Ulcer Col-M 
                 4.2 
               
               
                   
                 112735 Match Control Ulcer Col-M 
                 18.2 
               
               
                   
                 112382 Ulcer Col-M 
                 4.2 
               
               
                   
                 112394 Match Control Ulcer Col-M 
                 0.0 
               
               
                   
                 112383 Ulcer Col-M 
                 12.2 
               
               
                   
                 112736 Match Control Ulcer Col-M 
                 2.0 
               
               
                   
                 112423 Psoriasis-F 
                 3.9 
               
               
                   
                 112427 Match Control Psoriasis-F 
                 30.8 
               
               
                   
                 112418 Psoriasis-M 
                 4.6 
               
               
                   
                 112723 Match Control Psoriasis-M 
                 23.8 
               
               
                   
                 112419 Psoriasis-M 
                 2.7 
               
               
                   
                 112424 Match Control Psoriasis-M 
                 1.9 
               
               
                   
                 112420 Psoriasis-M 
                 4.9 
               
               
                   
                 112425 Match Control Psoriasis-M 
                 25.9 
               
               
                   
                 104689 (MF) OA Bone-Backus 
                 12.9 
               
               
                   
                 104690 (MF) Adj “Normal” Bone-Backus 
                 3.7 
               
               
                   
                 104691 (MF) OA Synovium-Backus 
                 6.9 
               
               
                   
                 104692 (BA) OA Cartilage-Backus 
                 21.3 
               
               
                   
                 104694 (BA) OA Bone-Backus 
                 6.6 
               
               
                   
                 104695 (BA) Adj “Normal” Bone-Backus 
                 2.3 
               
               
                   
                 104696 (BA) OA Synovium-Backus 
                 5.7 
               
               
                   
                 104700 (SS) OA Bone-Backus 
                 6.2 
               
               
                   
                 104701 (SS) Adj “Normal” Bone-Backus 
                 3.8 
               
               
                   
                 104702 (SS) OA Synovium-Backus 
                 15.4 
               
               
                   
                 117093 OA Cartilage Rep7 
                 18.0 
               
               
                   
                 112672 OA Bone5 
                 90.1 
               
               
                   
                 112673 OA Synovium5 
                 63.7 
               
               
                   
                 112674 OA Synovial Fluid cells5 
                 32.3 
               
               
                   
                 117100 OA Cartilage Rep14 
                 3.3 
               
               
                   
                 112756 OA Bone9 
                 7.0 
               
               
                   
                 112757 OA Synovium9 
                 12.2 
               
               
                   
                 112758 OA Synovial Fluid Cells9 
                 3.9 
               
               
                   
                 117125 RA Cartilage Rep2 
                 4.6 
               
               
                   
                 113492 Bone2 RA 
                 2.4 
               
               
                   
                 113493 Synovium2 RA 
                 1.1 
               
               
                   
                 113494 Syn Fluid Cells RA 
                 1.4 
               
               
                   
                 113499 Cartilage4 RA 
                 1.4 
               
               
                   
                 113500 Bone4 RA 
                 0.5 
               
               
                   
                 113501 Synovium4 RA 
                 1.7 
               
               
                   
                 113502 Syn Fluid Cells4 RA 
                 1.8 
               
               
                   
                 113495 Cartilage3 RA 
                 1.6 
               
               
                   
                 113496 Bone3 RA 
                 1.1 
               
               
                   
                 113497 Synovium3 RA 
                 0.0 
               
               
                   
                 113498 Syn Fluid Cells3 RA 
                 0.6 
               
               
                   
                 117106 Normal Cartilage Rep20 
                 4.5 
               
               
                   
                 113663 Bone3 Normal 
                 6.7 
               
               
                   
                 113664 Synovium3 Normal 
                 1.2 
               
               
                   
                 113665 Syn Fluid Cells3 Normal 
                 0.9 
               
               
                   
                 117107 Normal Cartilage Rep22 
                 1.3 
               
               
                   
                 113667 Bone4 Normal 
                 11.8 
               
               
                   
                 113668 Synovium4 Normal 
                 12.0 
               
               
                   
                 113669 Syn Fluid Cells4 Normal 
                 10.7 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1294b, Run 249007981    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BHE 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Adipose 
                 3.3 
               
               
                   
                 Melanoma* Hs688(A).T 
                 2.7 
               
               
                   
                 Melanoma* Hs688(B).T 
                 2.7 
               
               
                   
                 Melanoma* M14 
                 4.8 
               
               
                   
                 Melanoma* LOXIMVI 
                 0.1 
               
               
                   
                 Melanoma* SK-MEL-5 
                 0.4 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 0.2 
               
               
                   
                 Testis Pool 
                 4.3 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 1.6 
               
               
                   
                 Prostate Pool 
                 0.5 
               
               
                   
                 Placenta 
                 7.7 
               
               
                   
                 Uterus Pool 
                 0.1 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.7 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 0.6 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.3 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 1.1 
               
               
                   
                 Ovarian ca. IGROV-1 
                 1.4 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.7 
               
               
                   
                 Ovary 
                 5.0 
               
               
                   
                 Breast ca. MCF-7 
                 0.4 
               
               
                   
                 Breast ca. MDA-MB-231 
                 0.5 
               
               
                   
                 Breast ca. BT 549 
                 0.7 
               
               
                   
                 Breast ca. T47D 
                 4.2 
               
               
                   
                 Breast ca. MDA-N 
                 0.2 
               
               
                   
                 Breast Pool 
                 0.8 
               
               
                   
                 Trachea 
                 1.3 
               
               
                   
                 Lung 
                 5.5 
               
               
                   
                 Fetal Lung 
                 1.8 
               
               
                   
                 Lung ca. NCI-N417 
                 3.6 
               
               
                   
                 Lung ca. LX-1 
                 0.7 
               
               
                   
                 Lung ca. NCI-H146 
                 0.8 
               
               
                   
                 Lung ca. SHP-77 
                 0.3 
               
               
                   
                 Lung ca. A549 
                 0.8 
               
               
                   
                 Lung ca. NCI-H526 
                 2.1 
               
               
                   
                 Lung ca. NCI-H23 
                 0.8 
               
               
                   
                 Lung ca. NCI-H460 
                 1.2 
               
               
                   
                 Lung ca. HOP-62 
                 0.5 
               
               
                   
                 Lung ca. NCI-H522 
                 20.2 
               
               
                   
                 Liver 
                 11.6 
               
               
                   
                 Fetal Liver 
                 61.1 
               
               
                   
                 Liver ca. HepG2 
                 100.0 
               
               
                   
                 Kidney Pool 
                 6.7 
               
               
                   
                 Fetal Kidney 
                 2.0 
               
               
                   
                 Renal ca. 786-0 
                 1.7 
               
               
                   
                 Renal ca. A498 
                 1.3 
               
               
                   
                 Renal ca. ACHN 
                 2.5 
               
               
                   
                 Renal ca. UO-31 
                 10.6 
               
               
                   
                 Renal ca. TK-10 
                 41.8 
               
               
                   
                 Bladder 
                 1.8 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 2.0 
               
               
                   
                 Gastric ca. KATO III 
                 0.6 
               
               
                   
                 Colon ca. SW-948 
                 0.6 
               
               
                   
                 Colon ca. SW480 
                 0.7 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 12.8 
               
               
                   
                 Colon ca. HT29 
                 0.1 
               
               
                   
                 Colon ca. HCT-116 
                 3.7 
               
               
                   
                 Colon ca. CaCo-2 
                 31.9 
               
               
                   
                 Colon cancer tissue 
                 7.9 
               
               
                   
                 Colon ca. SW1116 
                 1.0 
               
               
                   
                 Colon ca. Colo-205 
                 0.0 
               
               
                   
                 Colon ca. SW-48 
                 0.0 
               
               
                   
                 Colon Pool 
                 1.0 
               
               
                   
                 Small Intestine Pool 
                 4.9 
               
               
                   
                 Stomach Pool 
                 3.4 
               
               
                   
                 Bone Marrow Pool 
                 0.0 
               
               
                   
                 Fetal Heart 
                 0.7 
               
               
                   
                 Heart Pool 
                 0.7 
               
               
                   
                 Lymph Node Pool 
                 2.6 
               
               
                   
                 Fetal Skeletal Muscle 
                 1.6 
               
               
                   
                 Skeletal Muscle Pool 
                 1.0 
               
               
                   
                 Spleen Pool 
                 0.4 
               
               
                   
                 Thymus Pool 
                 7.9 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 6.4 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 1.6 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 4.4 
               
               
                   
                 CNS cancer (astro) SF-539 
                 0.2 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 4.4 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 1.1 
               
               
                   
                 CNS cancer (glio) SF-295 
                 5.1 
               
               
                   
                 Brain (Amygdala) Pool 
                 2.5 
               
               
                   
                 Brain (cerebellum) 
                 7.3 
               
               
                   
                 Brain (fetal) 
                 12.2 
               
               
                   
                 Brain (Hippocampus) Pool 
                 1.9 
               
               
                   
                 Cerebral Cortex Pool 
                 2.6 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 2.1 
               
               
                   
                 Brain (Thalamus) Pool 
                 3.9 
               
               
                   
                 Brain (whole) 
                 8.5 
               
               
                   
                 Spinal Cord Pool 
                 1.9 
               
               
                   
                 Adrenal Gland 
                 2.6 
               
               
                   
                 Pituitary gland Pool 
                 0.6 
               
               
                   
                 Salivary Gland 
                 0.9 
               
               
                   
                 Thyroid (female) 
                 1.8 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 0.0 
               
               
                   
                 Pancreas Pool 
                 1.1 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag4726, Run 222842378    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BHF 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.2 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Endothelial cells 
                 12.3 
                 5.9 
               
               
                   
                 Heart (Fetal) 
                 0.0 
                 0.0 
               
               
                   
                 Pancreas 
                 0.0 
                 0.0 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 0.0 
                 0.0 
               
               
                   
                 Adrenal gland 
                 0.0 
                 0.2 
               
               
                   
                 Thyroid 
                 0.1 
                 0.0 
               
               
                   
                 Salivary gland 
                 0.0 
                 0.0 
               
               
                   
                 Pituitary gland 
                 0.2 
                 0.1 
               
               
                   
                 Brain (fetal) 
                 2.4 
                 16.0 
               
               
                   
                 Brain (whole) 
                 0.0 
                 0.3 
               
               
                   
                 Brain (amygdala) 
                 0.0 
                 0.0 
               
               
                   
                 Brain (cerebellum) 
                 0.0 
                 0.0 
               
               
                   
                 Brain (hippocampus) 
                 0.0 
                 0.0 
               
               
                   
                 Brain (thalamus) 
                 0.0 
                 0.0 
               
               
                   
                 Cerebral Cortex 
                 0.0 
                 0.0 
               
               
                   
                 Spinal cord 
                 0.0 
                 0.0 
               
               
                   
                 glio/astro U87-MG 
                 0.0 
                 0.0 
               
               
                   
                 glio/astro U-118-MG 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SW1783 
                 0.0 
                 0.0 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.0 
                 0.2 
               
               
                   
                 astrocytoma SF-539 
                 0.0 
                 0.0 
               
               
                   
                 astrocytoma SNB-75 
                 0.0 
                 0.0 
               
               
                   
                 glioma SNB-19 
                 0.0 
                 0.0 
               
               
                   
                 glioma U251 
                 0.0 
                 0.0 
               
               
                   
                 glioma SF-295 
                 0.0 
                 0.0 
               
               
                   
                 Heart 
                 0.0 
                 0.0 
               
               
                   
                 Skeletal muscle 
                 0.0 
                 0.0 
               
               
                   
                 Bone marrow 
                 0.0 
                 0.0 
               
               
                   
                 Thymus 
                 1.2 
                 2.8 
               
               
                   
                 Spleen 
                 0.0 
                 0.0 
               
               
                   
                 Lymph node 
                 0.0 
                 0.0 
               
               
                   
                 Colorectal 
                 0.0 
                 0.0 
               
               
                   
                 Stomach 
                 0.0 
                 0.0 
               
               
                   
                 Small intestine 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. SW480 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca.* SW620 (SW480 met) 
                 1.1 
                 1.9 
               
               
                   
                 Colon ca. HT29 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HCT-116 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. CaCo-2 
                 46.3 
                 56.6 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 0.0 
                 0.0 
               
               
                   
                 Colon ca. HCC-2998 
                 0.0 
                 0.0 
               
               
                   
                 Gastric ca. (liver met) NCI-N87 
                 0.0 
                 0.0 
               
               
                   
                 Bladder 
                 0.0 
                 0.0 
               
               
                   
                 Trachea 
                 0.0 
                 0.0 
               
               
                   
                 Kidney 
                 0.0 
                 0.0 
               
               
                   
                 Kidney (fetal) 
                 0.1 
                 0.9 
               
               
                   
                 Renal ca. 786-0 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. A498 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. RXF 393 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. ACHN 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. UO-31 
                 0.0 
                 0.0 
               
               
                   
                 Renal ca. TK-10 
                 0.0 
                 0.0 
               
               
                   
                 Liver 
                 32.8 
                 53.2 
               
               
                   
                 Liver (fetal) 
                 72.7 
                 100.0 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 100.0 
                 94.0 
               
               
                   
                 Lung 
                 0.0 
                 0.0 
               
               
                   
                 Lung (fetal) 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (large cell) NCI-H460 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 63.7 
                 90.1 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.0 
                 0.0 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 0.0 
                 0.0 
               
               
                   
                 Mammary gland 
                 0.7 
                 3.6 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. BT-549 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca. MDA-N 
                 0.0 
                 0.0 
               
               
                   
                 Ovary 
                 0.5 
                 11.7 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.0 
                 0.0 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 0.0 
                 0.0 
               
               
                   
                 Uterus 
                 0.0 
                 0.0 
               
               
                   
                 Placenta 
                 34.4 
                 39.5 
               
               
                   
                 Prostate 
                 0.0 
                 0.0 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 0.0 
                 0.0 
               
               
                   
                 Testis 
                 1.0 
                 3.5 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma UACC-62 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma M14 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma LOX IMVI 
                 0.0 
                 0.0 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 0.0 
                 0.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag746, Run 115163442    
               
               
                   
                   Column B - Rel. Exp. (%) Ag746, Run 119442272    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BHG 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Normal Colon 
                 18.3 
                 21.8 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 16.5 
                 23.7 
               
               
                   
                 CC Margin (ODO3866) 
                 3.1 
                 0.0 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 0.0 
                 0.8 
               
               
                   
                 CC Margin (ODO3868) 
                 0.5 
                 2.0 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 1.2 
                 2.3 
               
               
                   
                 CC Margin (ODO3920) 
                 1.3 
                 2.6 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 3.4 
                 4.4 
               
               
                   
                 CC Margin (ODO3921) 
                 1.3 
                 0.0 
               
               
                   
                 CC from Partial Hepatectomy 
                 8.4 
                 1.9 
               
               
                   
                 (ODO4309) Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 49.7 
                 41.5 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 0.3 
                 5.3 
               
               
                   
                 Lung Margin (OD04451-02) 
                 0.0 
                 1.8 
               
               
                   
                 Normal Prostate 6546-1 
                 9.1 
                 12.1 
               
               
                   
                 Prostate Cancer (OD04410) 
                 2.0 
                 9.7 
               
               
                   
                 Prostate Margin (OD04410) 
                 16.8 
                 20.3 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 13.5 
                 14.4 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 14.0 
                 22.4 
               
               
                   
                 Normal Lung 
                 6.8 
                 11.7 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 1.8 
                 0.7 
               
               
                   
                 Muscle Margin (ODO4286) 
                 11.5 
                 13.1 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 1.5 
                 6.0 
               
               
                   
                 Lung Margin (OD03126) 
                 4.8 
                 2.4 
               
               
                   
                 Lung Cancer (OD04404) 
                 4.2 
                 2.3 
               
               
                   
                 Lung Margin (OD04404) 
                 9.0 
                 10.4 
               
               
                   
                 Lung Cancer (OD04565) 
                 0.3 
                 0.0 
               
               
                   
                 Lung Margin (OD04565) 
                 0.4 
                 0.3 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 10.7 
                 11.1 
               
               
                   
                 Lung Margin (OD04237-02) 
                 4.9 
                 5.4 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 10.5 
                 11.9 
               
               
                   
                 Liver Margin (ODO4310) 
                 22.4 
                 32.8 
               
               
                   
                 Melanoma Metastasis 
                 0.0 
                 0.0 
               
               
                   
                 Lung Margin (OD04321) 
                 0.6 
                 0.0 
               
               
                   
                 Normal Kidney 
                 5.3 
                 5.3 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 39.8 
                 43.8 
               
               
                   
                 Kidney Margin (OD04338) 
                 4.8 
                 6.4 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 
                 3.0 
                 0.3 
               
               
                   
                 (OD04339) 
               
               
                   
                 Kidney Margin (OD04339) 
                 5.4 
                 10.0 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 18.2 
                 19.2 
               
               
                   
                 Kidney Margin (OD04340) 
                 9.0 
                 10.4 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 5.2 
                 8.3 
               
               
                   
                 Kidney Margin (OD04348) 
                 6.9 
                 4.7 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 41.8 
                 45.4 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 1.9 
                 1.4 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 9.2 
                 6.2 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 10.2 
                 9.0 
               
               
                   
                 Kidney Cancer 8120607 
                 2.2 
                 1.7 
               
               
                   
                 Kidney Margin 8120608 
                 6.5 
                 6.4 
               
               
                   
                 Kidney Cancer 8120613 
                 2.2 
                 0.7 
               
               
                   
                 Kidney Margin 8120614 
                 6.3 
                 3.0 
               
               
                   
                 Kidney Cancer 9010320 
                 10.9 
                 16.5 
               
               
                   
                 Kidney Margin 9010321 
                 9.0 
                 11.3 
               
               
                   
                 Normal Uterus 
                 4.3 
                 6.3 
               
               
                   
                 Uterine Cancer 064011 
                 13.4 
                 17.7 
               
               
                   
                 Normal Thyroid 
                 9.1 
                 14.9 
               
               
                   
                 Thyroid Cancer 
                 6.4 
                 5.9 
               
               
                   
                 Thyroid Cancer A302152 
                 4.4 
                 5.1 
               
               
                   
                 Thyroid Margin A302153 
                 12.0 
                 22.1 
               
               
                   
                 Normal Breast 
                 9.9 
                 14.3 
               
               
                   
                 Breast Cancer 
                 0.4 
                 0.2 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 5.3 
                 3.9 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 4.0 
                 10.4 
               
               
                   
                 Breast Cancer Metastasis 
                 7.2 
                 4.4 
               
               
                   
                 Breast Cancer 
                 5.2 
                 3.3 
               
               
                   
                 Breast Cancer 
                 12.1 
                 18.6 
               
               
                   
                 Breast Cancer 9100266 
                 2.7 
                 5.3 
               
               
                   
                 Breast Margin 9100265 
                 5.0 
                 5.8 
               
               
                   
                 Breast Cancer A209073 
                 0.5 
                 1.8 
               
               
                   
                 Breast Margin A209073 
                 1.7 
                 0.4 
               
               
                   
                 Normal Liver 
                 39.5 
                 47.0 
               
               
                   
                 Liver Cancer 
                 4.2 
                 0.6 
               
               
                   
                 Liver Cancer 1025 
                 66.4 
                 74.2 
               
               
                   
                 Liver Cancer 1026 
                 36.1 
                 42.6 
               
               
                   
                 Liver Cancer 6004-T 
                 100.0 
                 100.0 
               
               
                   
                 Liver Tissue 6004-N 
                 22.8 
                 34.4 
               
               
                   
                 Liver Cancer 6005-T 
                 39.2 
                 35.4 
               
               
                   
                 Liver Tissue 6005-N 
                 33.2 
                 38.2 
               
               
                   
                 Normal Bladder 
                 6.6 
                 4.9 
               
               
                   
                 Bladder Cancer 
                 1.0 
                 4.8 
               
               
                   
                 Bladder Cancer 
                 2.6 
                 0.7 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 0.0 
                 0.7 
               
               
                   
                 Bladder Normal Adjacent 
                 3.5 
                 14.4 
               
               
                   
                 (OD04718-03) 
               
               
                   
                 Normal Ovary 
                 50.7 
                 47.3 
               
               
                   
                 Ovarian Cancer 
                 10.2 
                 7.4 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 73.7 
                 80.7 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 2.6 
                 0.8 
               
               
                   
                 Normal Stomach 
                 2.9 
                 2.9 
               
               
                   
                 Gastric Cancer 9060358 
                 0.0 
                 1.1 
               
               
                   
                 Stomach Margin 9060359 
                 2.4 
                 0.3 
               
               
                   
                 Gastric Cancer 9060395 
                 0.5 
                 1.1 
               
               
                   
                 Stomach Margin 9060394 
                 5.2 
                 2.0 
               
               
                   
                 Gastric Cancer 9060397 
                 3.4 
                 7.0 
               
               
                   
                 Stomach Margin 9060396 
                 1.4 
                 0.0 
               
               
                   
                 Gastric Cancer 064005 
                 1.3 
                 6.0 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag746, Run 147127131    
               
               
                   
                   Column B - Rel. Exp. (%) Ag746, Run 148019631    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BHH 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Secondary Th1 act 
                 10.9 
                 7.7 
               
               
                   
                 Secondary Th2 act 
                 6.4 
                 8.0 
               
               
                   
                 Secondary Tr1 act 
                 11.3 
                 9.3 
               
               
                   
                 Secondary Th1 rest 
                 3.4 
                 2.7 
               
               
                   
                 Secondary Th2 rest 
                 1.5 
                 2.5 
               
               
                   
                 Secondary Tr1 rest 
                 1.4 
                 2.0 
               
               
                   
                 Primary Th1 act 
                 48.0 
                 46.0 
               
               
                   
                 Primary Th2 act 
                 38.7 
                 27.7 
               
               
                   
                 Primary Tr1 act 
                 72.2 
                 55.5 
               
               
                   
                 Primary Th1 rest 
                 3.1 
                 2.3 
               
               
                   
                 Primary Th2 rest 
                 1.0 
                 0.8 
               
               
                   
                 Primary Tr1 rest 
                 1.1 
                 0.5 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 2.9 
                 1.8 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 18.6 
                 12.2 
               
               
                   
                 CD8 lymphocyte act 
                 17.8 
                 6.8 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 6.8 
                 6.0 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 5.5 
                 4.1 
               
               
                   
                 CD4 lymphocyte none 
                 0.0 
                 0.2 
               
               
                   
                 2ry Th1/Th2/Tr1 anti-CD95 
                 2.9 
                 3.1 
               
               
                   
                 CH11 
               
               
                   
                 LAK cells rest 
                 1.4 
                 0.3 
               
               
                   
                 LAK cells IL-2 
                 3.8 
                 2.2 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 3.0 
                 0.8 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 2.0 
                 1.7 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 0.5 
                 0.2 
               
               
                   
                 LAK cells PMA/ionomycin 
                 0.7 
                 1.3 
               
               
                   
                 NK Cells IL-2 rest 
                 0.7 
                 0.7 
               
               
                   
                 Two Way MLR 3 day 
                 1.1 
                 2.5 
               
               
                   
                 Two Way MLR 5 day 
                 2.5 
                 2.8 
               
               
                   
                 Two Way MLR 7 day 
                 4.5 
                 5.0 
               
               
                   
                 PBMC rest 
                 0.0 
                 0.0 
               
               
                   
                 PBMC PWM 
                 41.8 
                 29.1 
               
               
                   
                 PBMC PHA-L 
                 34.4 
                 21.8 
               
               
                   
                 Ramos (B cell) none 
                 4.7 
                 2.4 
               
               
                   
                 Ramos (B cell) ionomycin 
                 9.2 
                 5.8 
               
               
                   
                 B lymphocytes PWM 
                 51.8 
                 51.4 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 10.2 
                 12.3 
               
               
                   
                 EOL-1 dbcAMP 
                 0.3 
                 0.2 
               
               
                   
                 EOL-1 dbcAMP 
                 0.4 
                 1.8 
               
               
                   
                 PMA/ionomycin 
               
               
                   
                 Dendritic cells none 
                 6.7 
                 3.8 
               
               
                   
                 Dendritic cells LPS 
                 4.7 
                 3.1 
               
               
                   
                 Dendritic cells anti-CD40 
                 6.0 
                 5.6 
               
               
                   
                 Monocytes rest 
                 0.0 
                 0.0 
               
               
                   
                 Monocytes LPS 
                 0.7 
                 0.8 
               
               
                   
                 Macrophages rest 
                 19.8 
                 9.9 
               
               
                   
                 Macrophages LPS 
                 0.7 
                 0.5 
               
               
                   
                 HUVEC none 
                 9.3 
                 10.2 
               
               
                   
                 HUVEC starved 
                 19.2 
                 13.1 
               
               
                   
                 HUVEC IL-1beta 
                 4.1 
                 1.7 
               
               
                   
                 HUVEC IFN gamma 
                 21.0 
                 13.7 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 2.8 
                 0.6 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 30.8 
                 25.7 
               
               
                   
                 HUVEC IL-11 
                 11.6 
                 7.3 
               
               
                   
                 Lung Microvascular EC none 
                 24.1 
                 20.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL- 
                 8.0 
                 12.2 
               
               
                   
                 1beta 
               
               
                   
                 Microvascular Dermal EC none 
                 64.6 
                 45.7 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL- 
                 18.4 
                 11.7 
               
               
                   
                 1beta 
               
               
                   
                 Bronchial epithelium 
                 5.2 
                 5.4 
               
               
                   
                 TNFalpha + IL1beta 
               
               
                   
                 Small airway epithelium none 
                 4.0 
                 3.2 
               
               
                   
                 Small airway epithelium TNFalpha + IL- 
                 8.2 
                 4.5 
               
               
                   
                 1beta 
               
               
                   
                 Coronery artery SMC rest 
                 5.8 
                 6.3 
               
               
                   
                 Coronery artery SMC 
                 4.5 
                 5.1 
               
               
                   
                 TNFalpha + IL-1beta 
               
               
                   
                 Astrocytes rest 
                 0.8 
                 0.5 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 3.6 
                 1.9 
               
               
                   
                 KU-812 (Basophil) rest 
                 16.0 
                 11.1 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 12.3 
                 9.5 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.0 
                 0.5 
               
               
                   
                 93580 CCD1106 (Keratinocytes) TNFa and 
                 0.7 
                 0.4 
               
               
                   
                 IFNg 
               
               
                   
                 Liver cirrhosis 
                 8.4 
                 3.8 
               
               
                   
                 Lupus kidney 
                 2.0 
                 3.2 
               
               
                   
                 NCI-H292 none 
                 21.9 
                 25.7 
               
               
                   
                 NCI-H292 IL-4 
                 15.7 
                 12.3 
               
               
                   
                 NCI-H292 IL-9 
                 20.6 
                 14.7 
               
               
                   
                 NCI-H292 IL-13 
                 8.3 
                 5.7 
               
               
                   
                 NCI-H292 IFN gamma 
                 5.1 
                 8.2 
               
               
                   
                 HPAEC none 
                 18.7 
                 23.8 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 11.9 
                 12.9 
               
               
                   
                 Lung fibroblast none 
                 15.7 
                 13.5 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 6.9 
                 4.7 
               
               
                   
                 Lung fibroblast IL-4 
                 25.0 
                 16.6 
               
               
                   
                 Lung fibroblast IL-9 
                 14.7 
                 15.8 
               
               
                   
                 Lung fibroblast IL-13 
                 40.3 
                 32.5 
               
               
                   
                 Lung fibroblast IFN gamma 
                 15.4 
                 17.4 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 0.5 
                 0.9 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 0.9 
                 0.8 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 0.6 
                 0.6 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 32.1 
                 18.4 
               
               
                   
                 Dermal fibroblast IL-4 
                 100.0 
                 100.0 
               
               
                   
                 IBD Colitis 2 
                 0.0 
                 0.0 
               
               
                   
                 IBD Crohn&#39;s 
                 0.3 
                 0.8 
               
               
                   
                 Colon 
                 1.4 
                 0.5 
               
               
                   
                 Lung 
                 0.5 
                 0.8 
               
               
                   
                 Thymus 
                 2.9 
                 4.3 
               
               
                   
                 Kidney 
                 65.5 
                 47.3 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag1294b, Run 138944262    
               
               
                   
                   Column B - Rel. Exp. (%) Ag1294b, Run 139408252    
               
            
           
         
       
     
      AI_comprehensive panel_v1.0 Summary: Ag1294b Expression of this gene in this panel confirmed expression of this gene in cells involved in the immune response. Highest expression of this gene was seen in normal lung (CT=30.5). Please see Panel 4D for discussion of utility of this gene in inflammation.  
      General_screeningpanel_v1.4 Summary: Ag4726 Highest expression of this gene was seen in a liver cancer cell line (CTs=30), with moderate levels of expression seen in fetal and adult liver, and cell lines derived from colon, renal and lung cancers. Thus, expression of this gene is useful as a marker to differentiate liver derived tissue from other samples on this panel.  
      Panel 1.2 Summary: Ag746 Highest expression of this gene was detected in a liver cancer cell line (CTs=27). High levels of expression were also seen in fetal and adult liver tissue, a colon cancer cell line and a lung cancer cell line. Thus, expression of this gene is useful as a marker to differentiate liver derived samples, the colon cancer cell line and the lung cancer cell line from other samples on this panel. Expression of this gene is also useful as a diagnostic marker to detect the presence of colon and lung cancers.  
      Moderate expression was also seen in the fetal brain, placenta, and endothelial cells.  
      Panel 2D Summary: Ag746 Highest expression of this gene was detected in a liver cancer sample (CTs=31). The prominent expression in liver derived tissue was consistent with the results in Panel 1.2. Moderate levels of expression were also evident in samples from ovarian cancer and kidney cancer. Expression of this gene was higher in these cancers than in the normal adjacent tissue. Thus, expression of this gene is useful as a marker to differentiate between liver derived samples and other samples on this panel and as a marker to detect the presence of liver, kidney, and ovarian cancer. Therapeutic modulation of the expression or function of this gene or its protein product is useful in the treatment of liver, kidney, and ovarian cancers.  
      Panel 4D Summary: Ag1294b Highest expression of this gene was detected in IL-4 treated dermal fibroblasts (CTs=30). In addition, this gene was expressed at moderate levels in IFN gamma stimulated dermal fibroblasts, activated lung fibroblasts, HPAECs, lung and dermal microvasculature, activated small airway and bronchial epithelium, activated NCI-H292 cells, acutely activated T cells, and activated B cells.  
      Based on these levels of expression in T cells, activated B cells and cells in lung and skin, therapeutics that block the function of this gene product are useful as therapeutics that reduce or eliminate the symptoms in patients with autoimmune and inflammatory diseases in which activated B cells present antigens in the generation of the aberrant immune response and in treating T-cell mediated diseases, including Crohn&#39;s disease, ulcerative colitis, multiple sclerosis, chronic obstructive pulmonary disease, asthma, allergy, emphysema, rheumatoid arthritis, or psoriasis.  
      BE. CG94946-01: Agrin Precursor  
      Expression of gene CG94946-01 was assessed using the primer-probe sets Ag3605 and Ag3974, described in Tables BIA and BIB. Results of the RTQ-PCR runs are shown in Tables BIC, BID, BIE and BIF.  
               TABLE BIA                          Probe Name Ag36O5                                         +HL,6           SEQ                       Start   ID       Primers   Sequences   Length   Position   No                                             Forward   5′-gaccccaagtcagaactgttc-3′   21   3514   1591                   Probe   TET-5′-attgagagcaccctggacgacctctt-3′-   26   3553   1592           TAMRA               Reverse   5′-gaaatccttcttgacgtctgaa-3′   22   3585   1593                  
 
     
       
         
           
               
             
               
                 TABLE BIB 
               
             
            
               
                   
               
               
                   
               
               
                 Probe Name Ag3974 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 +HL,6 
                   
                   
                 SEQ 
                   
               
               
                   
                   
                   
                 Start 
                 ID 
               
               
                 Primers 
                 Sequences 
                 Length 
                 Position 
                 No 
               
               
                   
               
               
                 Forward 
                 5′-gacaccaggatcttctttgtga-3′ 
                 22 
                 379 
                 1594 
                   
               
               
                   
               
               
                 Probe 
                 TET-5′-catacctgtggccagcccacaag-3′-TAMRA 
                 23 
                 413 
                 1595 
               
               
                   
               
               
                 Reverse 
                 5′-gagttgagcatcagctcgtt-3′ 
                 20 
                 436 
                 1596 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BIC 
               
             
            
               
                   
               
               
                   
               
               
                 General_screening_panel_v1.4 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Adipose 
                 1.4 
                 1.5 
               
               
                   
                 Melanoma* Hs688(A).T 
                 2.6 
                 3.2 
               
               
                   
                 Melanoma* Hs688(B).T 
                 4.6 
                 4.2 
               
               
                   
                 Melanoma* M14 
                 6.7 
                 6.4 
               
               
                   
                 Melanoma* LOXIMVI 
                 4.8 
                 4.0 
               
               
                   
                 Melanoma* SK-MEL-5 
                 2.6 
                 4.2 
               
               
                   
                 Squamous cell carcinoma SCC-4 
                 9.0 
                 8.4 
               
               
                   
                 Testis Pool 
                 1.3 
                 1.1 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 21.0 
                 24.8 
               
               
                   
                 Prostate Pool 
                 0.9 
                 0.8 
               
               
                   
                 Placenta 
                 0.9 
                 1.3 
               
               
                   
                 Uterus Pool 
                 0.4 
                 0.4 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 77.4 
                 66.9 
               
               
                   
                 Ovarian ca. SK-OV-3 
                 42.0 
                 36.3 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 9.5 
                 12.7 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 39.2 
                 44.4 
               
               
                   
                 Ovarian ca. IGROV-1 
                 22.1 
                 27.7 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 18.0 
                 14.9 
               
               
                   
                 Ovary 
                 1.5 
                 1.9 
               
               
                   
                 Breast ca. MCF-7 
                 7.7 
                 9.7 
               
               
                   
                 Breast ca. MDA-MB-231 
                 22.7 
                 31.2 
               
               
                   
                 Breast ca. BT 549 
                 13.2 
                 10.1 
               
               
                   
                 Breast ca. T47D 
                 100.0 
                 100.0 
               
               
                   
                 Breast ca. MDA-N 
                 4.8 
                 4.2 
               
               
                   
                 Breast Pool 
                 1.6 
                 1.6 
               
               
                   
                 Trachea 
                 2.8 
                 2.6 
               
               
                   
                 Lung 
                 0.2 
                 0.1 
               
               
                   
                 Fetal Lung 
                 11.4 
                 8.3 
               
               
                   
                 Lung ca. NCI-N417 
                 1.4 
                 0.7 
               
               
                   
                 Lung ca. LX-1 
                 10.5 
                 11.0 
               
               
                   
                 Lung ca. NCI-H146 
                 0.1 
                 0.1 
               
               
                   
                 Lung ca. SHP-77 
                 1.1 
                 0.8 
               
               
                   
                 Lung ca. A549 
                 15.6 
                 10.4 
               
               
                   
                 Lung ca. NCI-H526 
                 5.4 
                 1.6 
               
               
                   
                 Lung ca. NCI-H23 
                 18.9 
                 20.6 
               
               
                   
                 Lung ca. NCI-H460 
                 11.5 
                 9.3 
               
               
                   
                 Lung ca. HOP-62 
                 23.7 
                 23.0 
               
               
                   
                 Lung ca. NCI-H522 
                 1.8 
                 2.3 
               
               
                   
                 Liver 
                 0.5 
                 0.6 
               
               
                   
                 Fetal Liver 
                 0.8 
                 1.4 
               
               
                   
                 Liver ca. HepG2 
                 15.5 
                 12.6 
               
               
                   
                 Kidney Pool 
                 1.5 
                 2.5 
               
               
                   
                 Fetal Kidney 
                 5.8 
                 4.6 
               
               
                   
                 Renal ca. 786-0 
                 46.3 
                 39.5 
               
               
                   
                 Renal ca. A498 
                 13.8 
                 7.9 
               
               
                   
                 Renal ca. ACHN 
                 14.3 
                 15.9 
               
               
                   
                 Renal ca. UO-31 
                 41.5 
                 38.7 
               
               
                   
                 Renal ca. TK-10 
                 19.3 
                 16.4 
               
               
                   
                 Bladder 
                 8.4 
                 9.0 
               
               
                   
                 Gastric ca. (liver met.) NCI-N87 
                 87.7 
                 80.7 
               
               
                   
                 Gastric ca. KATO III 
                 17.8 
                 17.7 
               
               
                   
                 Colon ca. SW-948 
                 9.2 
                 7.8 
               
               
                   
                 Colon ca. SW480 
                 25.0 
                 32.3 
               
               
                   
                 Colon ca.* (SW480 met) SW620 
                 5.0 
                 4.6 
               
               
                   
                 Colon ca. HT29 
                 26.8 
                 30.6 
               
               
                   
                 Colon ca. HCT-116 
                 4.9 
                 5.8 
               
               
                   
                 Colon ca. CaCo-2 
                 13.6 
                 10.4 
               
               
                   
                 Colon cancer tissue 
                 10.2 
                 10.0 
               
               
                   
                 Colon ca. SW1116 
                 5.1 
                 3.6 
               
               
                   
                 Colon ca. Colo-205 
                 1.8 
                 1.5 
               
               
                   
                 Colon ca. SW-48 
                 1.2 
                 0.7 
               
               
                   
                 Colon Pool 
                 1.9 
                 1.3 
               
               
                   
                 Small Intestine Pool 
                 0.6 
                 1.0 
               
               
                   
                 Stomach Pool 
                 1.5 
                 1.2 
               
               
                   
                 Bone Marrow Pool 
                 0.6 
                 0.5 
               
               
                   
                 Fetal Heart 
                 1.4 
                 1.0 
               
               
                   
                 Heart Pool 
                 0.7 
                 0.8 
               
               
                   
                 Lymph Node Pool 
                 2.1 
                 2.0 
               
               
                   
                 Fetal Skeletal Muscle 
                 0.9 
                 0.5 
               
               
                   
                 Skeletal Muscle Pool 
                 0.4 
                 0.5 
               
               
                   
                 Spleen Pool 
                 0.7 
                 0.7 
               
               
                   
                 Thymus Pool 
                 1.8 
                 2.2 
               
               
                   
                 CNS cancer (glio/astro) U87-MG 
                 5.9 
                 6.0 
               
               
                   
                 CNS cancer (glio/astro) U-118-MG 
                 11.7 
                 11.2 
               
               
                   
                 CNS cancer (neuro; met) SK-N-AS 
                 1.2 
                 0.9 
               
               
                   
                 CNS cancer (astro) SF-539 
                 6.7 
                 5.0 
               
               
                   
                 CNS cancer (astro) SNB-75 
                 22.8 
                 32.3 
               
               
                   
                 CNS cancer (glio) SNB-19 
                 25.0 
                 20.2 
               
               
                   
                 CNS cancer (glio) SF-295 
                 35.1 
                 38.2 
               
               
                   
                 Brain (Amygdala) Pool 
                 1.7 
                 1.3 
               
               
                   
                 Brain (cerebellum) 
                 1.4 
                 1.0 
               
               
                   
                 Brain (fetal) 
                 7.0 
                 2.8 
               
               
                   
                 Brain (Hippocampus) Pool 
                 1.6 
                 0.9 
               
               
                   
                 Cerebral Cortex Pool 
                 1.9 
                 0.9 
               
               
                   
                 Brain (Substantia nigra) Pool 
                 2.8 
                 1.7 
               
               
                   
                 Brain (Thalamus) Pool 
                 2.7 
                 1.6 
               
               
                   
                 Brain (whole) 
                 3.4 
                 1.1 
               
               
                   
                 Spinal Cord Pool 
                 1.8 
                 1.4 
               
               
                   
                 Adrenal Gland 
                 0.2 
                 0.4 
               
               
                   
                 Pituitary gland Pool 
                 0.3 
                 0.2 
               
               
                   
                 Salivary Gland 
                 1.1 
                 1.3 
               
               
                   
                 Thyroid (female) 
                 3.3 
                 3.7 
               
               
                   
                 Pancreatic ca. CAPAN2 
                 23.7 
                 27.7 
               
               
                   
                 Pancreas Pool 
                 3.0 
                 4.1 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3605, Run 213406184    
               
               
                   
                   Column B - Rel. Exp. (%) Ag3974, Run 217508632    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BID 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2.2 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Normal Colon 
                 4.7 
               
               
                   
                 Colon cancer (OD06064) 
                 6.3 
               
               
                   
                 Colon Margin (OD06064) 
                 2.3 
               
               
                   
                 Colon cancer (OD06159) 
                 2.1 
               
               
                   
                 Colon Margin (OD06159) 
                 1.8 
               
               
                   
                 Colon cancer (OD06297-04) 
                 2.0 
               
               
                   
                 Colon Margin (OD06297-05) 
                 3.0 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 3.6 
               
               
                   
                 CC Margin (ODO3921) 
                 1.3 
               
               
                   
                 Colon cancer metastasis (OD06104) 
                 1.1 
               
               
                   
                 Lung Margin (OD06104) 
                 1.0 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 4.5 
               
               
                   
                 Lung Margin (OD04451-02) 
                 6.7 
               
               
                   
                 Normal Prostate 
                 2.1 
               
               
                   
                 Prostate Cancer (OD04410) 
                 3.9 
               
               
                   
                 Prostate Margin (OD04410) 
                 3.4 
               
               
                   
                 Normal Ovary 
                 7.6 
               
               
                   
                 Ovarian cancer (OD06283-03) 
                 27.9 
               
               
                   
                 Ovarian Margin (OD06283-07) 
                 2.0 
               
               
                   
                 Ovarian Cancer 
                 16.0 
               
               
                   
                 Ovarian cancer (OD06145) 
                 10.1 
               
               
                   
                 Ovarian Margin (OD06145) 
                 8.2 
               
               
                   
                 Ovarian cancer (OD06455-03) 
                 28.9 
               
               
                   
                 Ovarian Margin (OD06455-07) 
                 1.9 
               
               
                   
                 Normal Lung 
                 2.9 
               
               
                   
                 Invasive poor diff. lung adeno (ODO4945-01 
                 9.4 
               
               
                   
                 Lung Margin (ODO4945-03) 
                 7.9 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 7.5 
               
               
                   
                 Lung Margin (OD03126) 
                 7.0 
               
               
                   
                 Lung Cancer (OD05014A) 
                 17.0 
               
               
                   
                 Lung Margin (OD05014B) 
                 11.7 
               
               
                   
                 Lung cancer (OD06081) 
                 12.2 
               
               
                   
                 Lung Margin (OD06081) 
                 2.4 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 1.8 
               
               
                   
                 Lung Margin (OD04237-02) 
                 16.2 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 8.4 
               
               
                   
                 Liver Margin (ODO4310) 
                 2.9 
               
               
                   
                 Melanoma Metastasis 
                 4.0 
               
               
                   
                 Lung Margin (OD04321) 
                 3.8 
               
               
                   
                 Normal Kidney 
                 10.9 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 35.4 
               
               
                   
                 Kidney Margin (OD04338) 
                 20.4 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 52.9 
               
               
                   
                 Kidney Margin (OD04339) 
                 16.6 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 16.6 
               
               
                   
                 Kidney Margin (OD04340) 
                 7.4 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 11.2 
               
               
                   
                 Kidney Margin (OD04348) 
                 100.0 
               
               
                   
                 Kidney malignant cancer (OD06204B) 
                 21.6 
               
               
                   
                 Kidney normal adjacent tissue (OD06204E) 
                 23.2 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 53.2 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 21.3 
               
               
                   
                 Kidney Cancer 8120613 
                 1.1 
               
               
                   
                 Kidney Margin 8120614 
                 14.1 
               
               
                   
                 Kidney Cancer 9010320 
                 20.3 
               
               
                   
                 Kidney Margin 9010321 
                 15.0 
               
               
                   
                 Kidney Cancer 8120607 
                 71.7 
               
               
                   
                 Kidney Margin 8120608 
                 12.2 
               
               
                   
                 Normal Uterus 
                 7.3 
               
               
                   
                 Uterine Cancer 064011 
                 6.9 
               
               
                   
                 Normal Thyroid 
                 4.3 
               
               
                   
                 Thyroid Cancer 
                 27.0 
               
               
                   
                 Thyroid Cancer A302152 
                 19.1 
               
               
                   
                 Thyroid Margin A302153 
                 8.1 
               
               
                   
                 Normal Breast 
                 14.0 
               
               
                   
                 Breast Cancer 
                 13.4 
               
               
                   
                 Breast Cancer 
                 35.1 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 31.6 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 8.7 
               
               
                   
                 Breast Cancer Metastasis 
                 13.3 
               
               
                   
                 Breast Cancer 
                 21.5 
               
               
                   
                 Breast Cancer 9100266 
                 17.7 
               
               
                   
                 Breast Margin 9100265 
                 16.5 
               
               
                   
                 Breast Cancer A209073 
                 13.2 
               
               
                   
                 Breast Margin A209073 
                 35.4 
               
               
                   
                 Breast cancer (OD06083) 
                 24.5 
               
               
                   
                 Breast cancer node metastasis (OD06083) 
                 21.5 
               
               
                   
                 Normal Liver 
                 5.0 
               
               
                   
                 Liver Cancer 1026 
                 15.5 
               
               
                   
                 Liver Cancer 1025 
                 12.2 
               
               
                   
                 Liver Cancer 6004-T 
                 7.8 
               
               
                   
                 Liver Tissue 6004-N 
                 6.1 
               
               
                   
                 Liver Cancer 6005-T 
                 25.0 
               
               
                   
                 Liver Tissue 6005-N 
                 12.4 
               
               
                   
                 Liver Cancer 
                 12.9 
               
               
                   
                 Normal Bladder 
                 14.2 
               
               
                   
                 Bladder Cancer 
                 9.5 
               
               
                   
                 Bladder Cancer 
                 12.2 
               
               
                   
                 Normal Stomach 
                 8.7 
               
               
                   
                 Gastric Cancer 9060397 
                 8.9 
               
               
                   
                 Stomach Margin 9060396 
                 7.4 
               
               
                   
                 Gastric Cancer 9060395 
                 7.0 
               
               
                   
                 Stomach Margin 9060394 
                 7.5 
               
               
                   
                 Gastric Cancer 064005 
                 6.9 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3605, Run 173764229    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BIE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Secondary Th1 act 
                 1.0 
                 1.2 
               
               
                   
                 Secondary Th2 act 
                 5.1 
                 8.0 
               
               
                   
                 Secondary Tr1 act 
                 2.5 
                 3.5 
               
               
                   
                 Secondary Th1 rest 
                 0.0 
                 0.7 
               
               
                   
                 Secondary Th2 rest 
                 0.4 
                 0.2 
               
               
                   
                 Secondary Tr1 rest 
                 0.4 
                 1.2 
               
               
                   
                 Primary Th1 act 
                 3.6 
                 3.2 
               
               
                   
                 Primary Th2 act 
                 1.1 
                 2.0 
               
               
                   
                 Primary Tr1 act 
                 3.4 
                 2.9 
               
               
                   
                 Primary Th1 rest 
                 0.9 
                 0.4 
               
               
                   
                 Primary Th2 rest 
                 0.5 
                 0.2 
               
               
                   
                 Primary Tr1 rest 
                 0.2 
                 0.3 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 43.5 
                 22.7 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 5.0 
                 5.5 
               
               
                   
                 CD8 lymphocyte act 
                 3.9 
                 3.3 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 3.7 
                 3.3 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 3.3 
                 3.5 
               
               
                   
                 CD4 lymphocyte none 
                 0.3 
                 0.1 
               
               
                   
                 2ry Th1/Th2/Tr1 anti-CD95 CH11 
                 0.3 
                 0.4 
               
               
                   
                 LAK cells rest 
                 5.0 
                 6.4 
               
               
                   
                 LAK cells IL-2 
                 2.8 
                 1.7 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 1.4 
                 1.8 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 2.3 
                 1.1 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 2.9 
                 1.6 
               
               
                   
                 LAK cells PMA/ionomycin 
                 6.8 
                 4.6 
               
               
                   
                 NK Cells IL-2 rest 
                 1.6 
                 1.9 
               
               
                   
                 Two Way MLR 3 day 
                 10.7 
                 12.4 
               
               
                   
                 Two Way MLR 5 day 
                 6.5 
                 5.3 
               
               
                   
                 Two Way MLR 7 day 
                 4.3 
                 4.0 
               
               
                   
                 PBMC rest 
                 0.0 
                 0.6 
               
               
                   
                 PBMC PWM 
                 5.0 
                 4.9 
               
               
                   
                 PBMC PHA-L 
                 5.5 
                 3.4 
               
               
                   
                 Ramos (B cell) none 
                 0.4 
                 0.4 
               
               
                   
                 Ramos (B cell) ionomycin 
                 0.2 
                 0.2 
               
               
                   
                 B lymphocytes PWM 
                 2.4 
                 3.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 1.5 
                 3.7 
               
               
                   
                 EOL-1 dbcAMP 
                 3.4 
                 3.1 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 18.3 
                 8.0 
               
               
                   
                 Dendritic cells none 
                 14.8 
                 9.0 
               
               
                   
                 Dendritic cells LPS 
                 48.3 
                 32.8 
               
               
                   
                 Dendritic cells anti-CD40 
                 9.7 
                 8.8 
               
               
                   
                 Monocytes rest 
                 0.9 
                 1.4 
               
               
                   
                 Monocytes LPS 
                 66.4 
                 81.2 
               
               
                   
                 Macrophages rest 
                 16.2 
                 9.7 
               
               
                   
                 Macrophages LPS 
                 54.7 
                 43.8 
               
               
                   
                 HUVEC none 
                 9.3 
                 12.6 
               
               
                   
                 HUVEC starved 
                 14.4 
                 25.2 
               
               
                   
                 HUVEC IL-1beta 
                 15.6 
                 18.9 
               
               
                   
                 HUVEC IFN gamma 
                 12.9 
                 16.7 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 37.6 
                 34.9 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 31.4 
                 31.4 
               
               
                   
                 HUVEC IL-11 
                 14.9 
                 13.9 
               
               
                   
                 Lung Microvascular EC none 
                 79.0 
                 100.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL- 
                 100.0 
                 97.9 
               
               
                   
                 1beta 
               
               
                   
                 Microvascular Dermal EC none 
                 49.7 
                 48.3 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL- 
                 56.6 
                 47.0 
               
               
                   
                 1beta 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 78.5 
                 90.1 
               
               
                   
                 Small airway epithelium none 
                 31.0 
                 32.5 
               
               
                   
                 Small airway epithelium TNFalpha + IL- 
                 81.8 
                 93.3 
               
               
                   
                 1beta 
               
               
                   
                 Coronery artery SMC rest 
                 17.2 
                 28.5 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 22.2 
                 28.7 
               
               
                   
                 Astrocytes rest 
                 80.1 
                 55.1 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 82.9 
                 66.4 
               
               
                   
                 KU-812 (Basophil) rest 
                 2.6 
                 1.9 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 0.6 
                 2.8 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 70.7 
                 82.4 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL- 
                 77.4 
                 72.7 
               
               
                   
                 1beta 
               
               
                   
                 Liver cirrhosis 
                 13.2 
                 14.4 
               
               
                   
                 NCI-H292 none 
                 57.8 
                 54.0 
               
               
                   
                 NCI-H292 IL-4 
                 62.4 
                 78.5 
               
               
                   
                 NCI-H292 IL-9 
                 61.6 
                 79.6 
               
               
                   
                 NCI-H292 IL-13 
                 53.6 
                 59.9 
               
               
                   
                 NCI-H292 IFN gamma 
                 67.4 
                 71.7 
               
               
                   
                 HPAEC none 
                 21.5 
                 21.3 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 37.6 
                 45.4 
               
               
                   
                 Lung fibroblast none 
                 22.4 
                 29.3 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 71.2 
                 87.7 
               
               
                   
                 Lung fibroblast IL-4 
                 16.2 
                 23.3 
               
               
                   
                 Lung fibroblast IL-9 
                 31.9 
                 30.4 
               
               
                   
                 Lung fibroblast IL-13 
                 18.7 
                 36.6 
               
               
                   
                 Lung fibroblast IFN gamma 
                 23.0 
                 29.7 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 15.9 
                 27.2 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 15.9 
                 20.6 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 17.2 
                 22.4 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 7.2 
                 10.3 
               
               
                   
                 Dermal fibroblast IL-4 
                 7.2 
                 8.0 
               
               
                   
                 Dermal Fibroblasts rest 
                 4.3 
                 6.3 
               
               
                   
                 Neutrophils TNFa + LPS 
                 0.0 
                 0.9 
               
               
                   
                 Neutrophils rest 
                 0.2 
                 1.0 
               
               
                   
                 Colon 
                 7.0 
                 5.8 
               
               
                   
                 Lung 
                 23.3 
                 23.3 
               
               
                   
                 Thymus 
                 5.8 
                 7.3 
               
               
                   
                 Kidney 
                 23.2 
                 33.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3605, Run 169943454    
               
               
                   
                   Column B - Rel. Exp. (%) Ag3974, Run 170739806    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BIF 
               
             
            
               
                   
               
               
                   
               
               
                 general oncology screening panel_v_2.4 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Colon cancer 1 
                 11.6 
               
               
                   
                 CC Margin (ODO3921) 
                 5.3 
               
               
                   
                 Colon cancer 2 
                 18.6 
               
               
                   
                 Colon NAT 2 
                 3.2 
               
               
                   
                 Colon cancer 3 
                 22.2 
               
               
                   
                 Colon NAT 3 
                 7.7 
               
               
                   
                 Colon malignant cancer 4 
                 23.5 
               
               
                   
                 Colon NAT 4 
                 2.0 
               
               
                   
                 Lung cancer 1 
                 57.0 
               
               
                   
                 Lung NAT 1 
                 3.1 
               
               
                   
                 Lung cancer 2 
                 100.0 
               
               
                   
                 Lung NAT 2 
                 3.9 
               
               
                   
                 Squamous cell carcinoma 3 
                 41.2 
               
               
                   
                 Lung NAT 3 
                 1.7 
               
               
                   
                 Metastatic melanoma 1 
                 5.4 
               
               
                   
                 Melanoma 2 
                 3.2 
               
               
                   
                 Melanoma 3 
                 3.7 
               
               
                   
                 Metastatic melanoma 4 
                 12.5 
               
               
                   
                 Metastatic melanoma 5 
                 7.9 
               
               
                   
                 Bladder cancer 1 
                 0.5 
               
               
                   
                 Bladder NAT 1 
                 0.0 
               
               
                   
                 Bladder cancer 2 
                 6.0 
               
               
                   
                 Bladder NAT 2 
                 0.2 
               
               
                   
                 Bladder NAT 3 
                 1.7 
               
               
                   
                 Bladder NAT 4 
                 1.8 
               
               
                   
                 Prostate adenocarcinoma 1 
                 2.4 
               
               
                   
                 Prostate adenocarcinoma 2 
                 2.6 
               
               
                   
                 Prostate adenocarcinoma 3 
                 5.2 
               
               
                   
                 Prostate adenocarcinoma 4 
                 21.9 
               
               
                   
                 Prostate NAT 5 
                 5.4 
               
               
                   
                 Prostate adenocarcinoma 6 
                 4.4 
               
               
                   
                 Prostate adenocarcinoma 7 
                 3.8 
               
               
                   
                 Prostate adenocarcinoma 8 
                 1.8 
               
               
                   
                 Prostate adenocarcinoma 9 
                 10.7 
               
               
                   
                 Prostate NAT 10 
                 0.7 
               
               
                   
                 Kidney cancer 1 
                 38.7 
               
               
                   
                 Kidney NAT 1 
                 20.6 
               
               
                   
                 Kidney cancer 2 
                 66.4 
               
               
                   
                 Kidney NAT 2 
                 39.8 
               
               
                   
                 Kidney cancer 3 
                 64.6 
               
               
                   
                 Kidney NAT 3 
                 19.6 
               
               
                   
                 Kidney cancer 4 
                 16.4 
               
               
                   
                 Kidney NAT 4 
                 15.6 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag3605, Run 260268655    
               
            
           
         
       
     
      General_screening_panel_v1.4 Summary: Ag3605/Ag3974 The expression of this gene was highest in a sample derived from a breast cancer cell line (T47D) (CTs=22.5-25.3). In addition, there was substantial expression in other samples derived from breast cancer cell lines, ovarian cancer cell lines, kidney cancer cell lines, lung cancer cell lines, colon cancer cell lines and brain cancer cell lines. Thus, the expression of this gene is useful as a marker to distinguish T47D cells from other samples in the panel. Therapeutic modulation of this gene or its protein product through the use of small molecule drugs, protein therapeutics, or antibodies is of benefit in the treatment of breast, ovarian, kidney, lung, colon or brain cancer.  
      Among metabolic tissues, this gene had low-to-moderate levels of expression in adrenal, pituitary, adult and fetal heart, adult and fetal liver, adult and fetal skeletal muscle, and adipose. This gene product had high levels of expression (CT values=27) in pancreas and thyroid. Thus, this gene product is important for the pathogenesis, diagnosis, and/or treatment of metabolic and endocrine diseases, including obesity, Types 1 and 2 diabetes and thyroidopathies. Decreased glomerular expression of agrin has been observed in diabetic nephropathy and supports this use of this gene or gene product. (Yard B A, Exp Nephrol 2001;9(3):214-22 ).  
      In addition, this gene was expressed at moderate levels in all regions of the central nervous system examined, including amygdala, hippocampus, substantia nigra, thalamus, cerebellum, cerebral cortex, and spinal cord. This gene encodes a protein with homology to agrin, a neuronal aggregating factor that induces the aggregation of acetylcholine receptors and other postsynaptic proteins on muscle fibers and is crucial for the formation of the neuromuscular junction. Agrin also plays an important role in defining neuronal responses to excitatory neurotransmitters both in vitro and in vivo (Hilgenberg L G, Mol Cell Neurosci 2002 January; 19(1):97-110 and Bixby J L, J Neurobiol 2002 February 5;50(2):164-79). The gene expression in the central nervous system is consistent the use of the protein and its function as an agrin. This gene plays a role in central nervous system disorders such as Alzheimer&#39;s disease, Parkinson&#39;s disease, epilepsy, multiple sclerosis, schizophrenia and depression.  
      Agrin has also been implicated in the formation of senile plaques in Alzheimer&#39;s disease and in the acetylcholine synapse/neuromuscular junction (van Horssen J, Acta Neuropathol (Berl) 2001 December;102(6):604-14). In addition, an agrin minigene rescued dystrophic symptoms in a mouse model of muscular dystrophy (Moll J, Nature. 2001 September 20;413(6853):302-7). Therefore, this gene or gene product is useful as a treatment or cure for congenital muscular dystrophies. Furthermore, this gene product is also an excellent drug target in AD or in any disease involving the neuromuscular junction or the acetylcholine system.  
      Panel 2.2 Summary: Ag3605 Expression of this gene was highest in a sample of normal kidney (CT=27.4). In addition, expression of this gene was upregulated in a number of ovarian and renal cancers when compared to the matched control margins.  
      Thus, expression of this gene is useful as a marker for ovarian and renal carcinoma. Furthermore, therapeutic modulation of the activity of this gene or its protein product, using small molecule drugs, antibodies or protein therapeutics, is of benefit in the treatment of renal and ovarian cancer.  
      Panel 4.1D Summary: Ag3605/Ag3974 Highest expression of this gene was highest in lung microvascular endothelial cells (CTs=27.3-28.5), microvascular dermal endothelial cells, mucoepidermoid cell line NCI-H292, astrocytes, and keratinocytes.  
      This gene encodes a protein with homology to agrin. Agrin, an aggregating protein crucial for formation of the neuromuscular junction, is important for T cell signaling in the immune system (Khan AA, Science 2001 June 1;292(5522):1681-6). In addition, agrin has been identified as a potential disease target for autoimmune disorders at the neuromuscularjunction, including multiple sclerosis (Liyanage Y, Muscle Nerve 2002 January;25(1):4-16). Therefore, small molecule drug, antibody or protein therapeutics that target this gene or the protein encoded by the gene is useful for the reduction or inhibition of inflammation in asthma, emphysema, allergy, psoriasis, muscular dystrophy and multiple sclerosis.  
      general oncology screening panel_V — 2.4 Summary: Ag3605 Highest expression of this gene was seen in a lung cancer sample (CT=26.8). In addition, higher levels of expression were seen in lung and kidney cancers when compared to expression in normal adjacent tissue. Thus, expression of this gene is useful as a marker of lung and kidney cancers. Therapeutic modulation of the expression or function of this gene or gene product is useful in the treatment of lung and kidney cancers.  
      BJ. CG9638401: Novel Plasma Membrane Protein  
      Expression of gene CG96384-01 was assessed using the primer-probe set Ag4093, described in Table BJA. Results of the RTQ-PCR run are shown in Table BJB.  
               TABLE BJA                          Probe Name Ag4093                                         +HL,6           SEQ                       Start   ID       Primers   Sequences   Length   Position   No                                             Forward   5′-agctggagcacaggagagat-3′   20   158   1597                   Probe   TET-5′-ggaagctctcctttgacactcgttcc-3′-   26   197   1598           TAMRA               Reverse   5′-acccatggtcttccagaaag-3′   20   231   1599                  
 
     
       
         
           
               
             
               
                 TABLE BJB 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4.1D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 55.1 
               
               
                   
                 Secondary Th2 act 
                 87.7 
               
               
                   
                 Secondary Tr1 act 
                 82.9 
               
               
                   
                 Secondary Th1 rest 
                 30.4 
               
               
                   
                 Secondary Th2 rest 
                 43.2 
               
               
                   
                 Secondary Tr1 rest 
                 38.7 
               
               
                   
                 Primary Th1 act 
                 57.4 
               
               
                   
                 Primary Th2 act 
                 100.0 
               
               
                   
                 Primary Tr1 act 
                 62.0 
               
               
                   
                 Primary Th1 rest 
                 28.3 
               
               
                   
                 Primary Th2 rest 
                 21.5 
               
               
                   
                 Primary Tr1 rest 
                 42.0 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 40.9 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 84.1 
               
               
                   
                 CD8 lymphocyte act 
                 70.2 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 56.6 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 26.6 
               
               
                   
                 CD4 lymphocyte none 
                 36.1 
               
               
                   
                 2ry Th1/Th2/Tr1 anti-CD95 CH11 
                 67.4 
               
               
                   
                 LAK cells rest 
                 38.2 
               
               
                   
                 LAK cells IL-2 
                 46.0 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 42.3 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 25.7 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 35.4 
               
               
                   
                 LAK cells PMA/ionomycin 
                 47.0 
               
               
                   
                 NK Cells IL-2 rest 
                 74.7 
               
               
                   
                 Two Way MLR 3 day 
                 36.3 
               
               
                   
                 Two Way MLR 5 day 
                 19.6 
               
               
                   
                 Two Way MLR 7 day 
                 58.6 
               
               
                   
                 PBMC rest 
                 26.1 
               
               
                   
                 PBMC PWM 
                 10.9 
               
               
                   
                 PBMC PHA-L 
                 42.9 
               
               
                   
                 Ramos (B cell) none 
                 18.9 
               
               
                   
                 Ramos (B cell) ionomycin 
                 6.1 
               
               
                   
                 B lymphocytes PWM 
                 27.7 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 48.0 
               
               
                   
                 EOL-1 dbcAMP 
                 21.2 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 31.4 
               
               
                   
                 Dendritic cells none 
                 17.4 
               
               
                   
                 Dendritic cells LPS 
                 10.7 
               
               
                   
                 Dendritic cells anti-CD40 
                 16.7 
               
               
                   
                 Monocytes rest 
                 29.5 
               
               
                   
                 Monocytes LPS 
                 28.3 
               
               
                   
                 Macrophages rest 
                 13.9 
               
               
                   
                 Macrophages LPS 
                 7.6 
               
               
                   
                 HUVEC none 
                 14.8 
               
               
                   
                 HUVEC starved 
                 36.6 
               
               
                   
                 HUVEC IL-1beta 
                 18.8 
               
               
                   
                 HUVEC IFN gamma 
                 23.3 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 11.3 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 20.7 
               
               
                   
                 HUVEC IL-11 
                 12.2 
               
               
                   
                 Lung Microvascular EC none 
                 21.0 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 15.3 
               
               
                   
                 Microvascular Dermal EC none 
                 12.6 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 15.8 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 16.8 
               
               
                   
                 Small airway epithelium none 
                 9.3 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 14.2 
               
               
                   
                 Coronery artery SMC rest 
                 8.9 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1 beta 
                 7.3 
               
               
                   
                 Astrocytes rest 
                 9.8 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 8.2 
               
               
                   
                 KU-812 (Basophil) rest 
                 11.4 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 18.3 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 13.2 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 17.3 
               
               
                   
                 Liver cirrhosis 
                 9.7 
               
               
                   
                 NCI-H292 none 
                 15.8 
               
               
                   
                 NCI-H292 IL-4 
                 32.5 
               
               
                   
                 NCI-H292 IL-9 
                 33.2 
               
               
                   
                 NCI-H292 IL-13 
                 45.1 
               
               
                   
                 NCI-H292 IFN gamma 
                 12.8 
               
               
                   
                 HPAEC none 
                 24.3 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 36.6 
               
               
                   
                 Lung fibroblast none 
                 18.7 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 2.9 
               
               
                   
                 Lung fibroblast IL-4 
                 6.4 
               
               
                   
                 Lung fibroblast IL-9 
                 17.4 
               
               
                   
                 Lung fibroblast IL-13 
                 15.5 
               
               
                   
                 Lung fibroblast IFN gamma 
                 14.9 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 17.9 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 67.8 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 15.2 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 9.7 
               
               
                   
                 Dermal fibroblast IL-4 
                 44.1 
               
               
                   
                 Dermal Fibroblasts rest 
                 16.6 
               
               
                   
                 Neutrophils TNFa + LPS 
                 2.4 
               
               
                   
                 Neutrophils rest 
                 19.6 
               
               
                   
                 Colon 
                 8.1 
               
               
                   
                 Lung 
                 8.7 
               
               
                   
                 Thymus 
                 84.1 
               
               
                   
                 Kidney 
                 55.9 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag4093, Run 172383903    
               
            
           
         
       
     
      Panel 4.1D Summary: Ag4093 This gene was widely expressed in this panel, with highest expression in primary activated Th2 cells (CT=32.7). This gene was also expressed. at high to moderate levels in a wide range of cell types of significance in the immune response in health and disease. These cells include members of the T-cell, B-cell, endothelial cell, monocyte, and peripheral blood mononuclear cell families, as well as dermal fibroblasts and normal tissues represented from thymus and kidney. This pattern of expression shows that this gene product is involved in homeostatic processes for these and other cell types and tissues. Therefore, modulation of the gene or gene product with a functional therapeutic is useful in the alteration of functions associated with these cell types and in the treatment of the symptoms of patients suffering from autoimmune and inflammatory diseases such as asthma, allergies, inflammatory bowel disease, lupus erythematosus, psoriasis, rheumatoid arthritis, and osteoarthritis.  
      BK. CG98011-01: Insulin-like Growth Factor Binding Protein  
      Expression of gene CG9801 1-01 was assessed using the primer-probe set Ag2120, described in Table BKA. Results of the RTQ-PCR runs are shown in Tables BKB, BKC, BKD and BKE.  
               TABLE BKA                          Probe Name Ag2120                                         +HL,6           SEQ                       Start   ID       Primers   Sequences   Length   Position   No                                             Forward   5′-gctgattgcaagaagatgtttc-3′   22   103   1600                   Probe   TET-5′-ttttgtcagccctgatttcttcgaca-3′-   26   140   1601               Reverse   5′-ccgatatgtcagaatctgcatt-3′   22   166   1602                  
 
     
       
         
           
               
             
               
                 TABLE BKB 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 1.3D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Liver adenocarcinoma 
                 0.5 
                 0.1 
               
               
                   
                 Pancreas 
                 0.3 
                 0.2 
               
               
                   
                 Pancreatic ca. CAPAN 2 
                 1.0 
                 1.1 
               
               
                   
                 Adrenal gland 
                 12.8 
                 10.8 
               
               
                   
                 Thyroid 
                 2.1 
                 1.3 
               
               
                   
                 Salivary gland 
                 0.6 
                 1.1 
               
               
                   
                 Pituitary gland 
                 0.6 
                 0.3 
               
               
                   
                 Brain (fetal) 
                 7.9 
                 8.8 
               
               
                   
                 Brain (whole) 
                 26.8 
                 23.8 
               
               
                   
                 Brain (amygdala) 
                 27.5 
                 17.8 
               
               
                   
                 Brain (cerebellum) 
                 17.4 
                 19.2 
               
               
                   
                 Brain (hippocampus) 
                 64.6 
                 58.6 
               
               
                   
                 Brain (substantia nigra) 
                 2.2 
                 3.5 
               
               
                   
                 Brain (thalamus) 
                 3.6 
                 3.0 
               
               
                   
                 Cerebral Cortex 
                 100.0 
                 100.0 
               
               
                   
                 Spinal cord 
                 0.5 
                 1.2 
               
               
                   
                 glio/astro U87-MG 
                 0.8 
                 0.5 
               
               
                   
                 glio/astro U-118-MG 
                 3.2 
                 4.7 
               
               
                   
                 astrocytoma SW1783 
                 0.7 
                 0.8 
               
               
                   
                 neuro*; met SK-N-AS 
                 0.4 
                 0.2 
               
               
                   
                 astrocytoma SF-539 
                 0.4 
                 0.3 
               
               
                   
                 astrocytoma SNB-75 
                 0.5 
                 0.2 
               
               
                   
                 glioma SNB-19 
                 0.4 
                 1.2 
               
               
                   
                 glioma U251 
                 1.6 
                 1.3 
               
               
                   
                 glioma SF-295 
                 1.9 
                 0.8 
               
               
                   
                 Heart (Fetal) 
                 3.3 
                 2.2 
               
               
                   
                 Heart 
                 0.3 
                 0.6 
               
               
                   
                 Skeletal muscle (Fetal) 
                 6.8 
                 9.3 
               
               
                   
                 Skeletal muscle 
                 3.4 
                 4.0 
               
               
                   
                 Bone marrow 
                 0.9 
                 1.6 
               
               
                   
                 Thymus 
                 0.9 
                 0.5 
               
               
                   
                 Spleen 
                 0.4 
                 0.1 
               
               
                   
                 Lymph node 
                 1.2 
                 0.6 
               
               
                   
                 Colorectal 
                 1.6 
                 1.1 
               
               
                   
                 Stomach 
                 1.0 
                 0.2 
               
               
                   
                 Small intestine 
                 0.2 
                 2.0 
               
               
                   
                 Colon ca. SW480 
                 0.8 
                 1.6 
               
               
                   
                 Colon ca.* SW620 (SW480 met) 
                 0.0 
                 1.4 
               
               
                   
                 Colon ca. HT29 
                 0.2 
                 0.5 
               
               
                   
                 Colon ca. HCT-116 
                 0.3 
                 0.2 
               
               
                   
                 Colon ca. CaCo-2 
                 0.6 
                 0.0 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 1.5 
                 0.5 
               
               
                   
                 Colon ca. HCC-2998 
                 0.6 
                 0.3 
               
               
                   
                 Gastric ca. (liver met) NCI-N87 
                 0.5 
                 1.2 
               
               
                   
                 Bladder 
                 1.8 
                 1.0 
               
               
                   
                 Trachea 
                 0.6 
                 1.3 
               
               
                   
                 Kidney 
                 1.3 
                 2.5 
               
               
                   
                 Kidney (fetal) 
                 1.7 
                 4.0 
               
               
                   
                 Renal ca. 786-0 
                 3.8 
                 3.7 
               
               
                   
                 Renal ca. A498 
                 2.6 
                 3.0 
               
               
                   
                 Renal ca. RXF 393 
                 2.2 
                 2.3 
               
               
                   
                 Renal ca. ACHN 
                 1.1 
                 0.8 
               
               
                   
                 Renal ca. UO-31 
                 0.5 
                 1.2 
               
               
                   
                 Renal ca. TK-10 
                 3.7 
                 3.6 
               
               
                   
                 Liver 
                 0.8 
                 0.0 
               
               
                   
                 Liver (fetal) 
                 0.2 
                 0.1 
               
               
                   
                 Liver ca. (hepatoblast) HepG2 
                 0.7 
                 0.8 
               
               
                   
                 Lung 
                 0.2 
                 0.7 
               
               
                   
                 Lung (fetal) 
                 0.4 
                 0.6 
               
               
                   
                 Lung ca. (small cell) LX-1 
                 1.2 
                 0.1 
               
               
                   
                 Lung ca. (small cell) NCI-H69 
                 44.8 
                 40.9 
               
               
                   
                 Lung ca. (s. cell var.) SHP-77 
                 5.6 
                 5.2 
               
               
                   
                 Lung ca. (large cell)NCI-H460 
                 54.3 
                 74.2 
               
               
                   
                 Lung ca. (non-sm. cell) A549 
                 0.5 
                 0.0 
               
               
                   
                 Lung ca. (non-s. cell) NCI-H23 
                 1.5 
                 2.0 
               
               
                   
                 Lung ca. (non-s. cell) HOP-62 
                 7.0 
                 5.3 
               
               
                   
                 Lung ca. (non-s. cl) NCI-H522 
                 1.1 
                 0.0 
               
               
                   
                 Lung ca. (squam.) SW 900 
                 0.3 
                 0.8 
               
               
                   
                 Lung ca. (squam.) NCI-H596 
                 8.4 
                 11.1 
               
               
                   
                 Mammary gland 
                 2.4 
                 2.0 
               
               
                   
                 Breast ca.* (pl. ef) MCF-7 
                 1.0 
                 0.7 
               
               
                   
                 Breast ca.* (pl. ef) MDA-MB-231 
                 0.0 
                 0.0 
               
               
                   
                 Breast ca.* (pl. ef) T47D 
                 17.3 
                 18.7 
               
               
                   
                 Breast ca. BT-549 
                 4.2 
                 4.7 
               
               
                   
                 Breast ca. MDA-N 
                 9.3 
                 9.9 
               
               
                   
                 Ovary 
                 12.4 
                 9.9 
               
               
                   
                 Ovarian ca. OVCAR-3 
                 0.1 
                 0.0 
               
               
                   
                 Ovarian ca. OVCAR-4 
                 0.5 
                 2.7 
               
               
                   
                 Ovarian ca. OVCAR-5 
                 0.9 
                 0.9 
               
               
                   
                 Ovarian ca. OVCAR-8 
                 2.1 
                 4.0 
               
               
                   
                 Ovarian ca. IGROV-1 
                 0.4 
                 0.3 
               
               
                   
                 Ovarian ca. (ascites) SK-OV-3 
                 0.8 
                 0.1 
               
               
                   
                 Uterus 
                 1.2 
                 0.7 
               
               
                   
                 Placenta 
                 1.8 
                 0.1 
               
               
                   
                 Prostate 
                 0.5 
                 0.6 
               
               
                   
                 Prostate ca.* (bone met) PC-3 
                 3.1 
                 2.2 
               
               
                   
                 Testis 
                 1.2 
                 1.3 
               
               
                   
                 Melanoma Hs688(A).T 
                 0.8 
                 0.9 
               
               
                   
                 Melanoma* (met) Hs688(B).T 
                 1.2 
                 2.7 
               
               
                   
                 Melanoma UACC-62 
                 0.7 
                 0.7 
               
               
                   
                 Melanoma M14 
                 4.0 
                 5.5 
               
               
                   
                 Melanoma LOX IMVI 
                 1.6 
                 0.3 
               
               
                   
                 Melanoma* (met) SK-MEL-5 
                 4.2 
                 3.7 
               
               
                   
                 Adipose 
                 3.1 
                 1.9 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2120, Run 149975625    
               
               
                   
                   Column B - Rel. Exp. (%) Ag2120, Run 150253839    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BKC 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 2D 
               
            
           
           
               
               
               
               
            
               
                   
                 Tissue Name 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Normal Colon 
                 7.3 
                 7.4 
               
               
                   
                 CC Well to Mod Diff (ODO3866) 
                 4.3 
                 7.9 
               
               
                   
                 CC Margin (ODO3866) 
                 1.7 
                 2.9 
               
               
                   
                 CC Gr.2 rectosigmoid (ODO3868) 
                 2.3 
                 1.5 
               
               
                   
                 CC Margin (ODO3868) 
                 1.7 
                 3.8 
               
               
                   
                 CC Mod Diff (ODO3920) 
                 0.2 
                 0.9 
               
               
                   
                 CC Margin (ODO3920) 
                 0.1 
                 2.5 
               
               
                   
                 CC Gr.2 ascend colon (ODO3921) 
                 0.5 
                 0.4 
               
               
                   
                 CC Margin (ODO3921) 
                 5.8 
                 6.4 
               
               
                   
                 CC from Partial Hepatectomy 
                 6.1 
                 8.7 
               
               
                   
                 (ODO4309) Mets 
               
               
                   
                 Liver Margin (ODO4309) 
                 4.0 
                 2.2 
               
               
                   
                 Colon mets to lung (OD04451-01) 
                 0.0 
                 0.3 
               
               
                   
                 Lung Margin (OD04451-02) 
                 2.9 
                 3.9 
               
               
                   
                 Normal Prostate 6546-1 
                 3.0 
                 7.8 
               
               
                   
                 Prostate Cancer (OD04410) 
                 8.5 
                 9.0 
               
               
                   
                 Prostate Margin (OD04410) 
                 23.5 
                 21.5 
               
               
                   
                 Prostate Cancer (OD04720-01) 
                 7.3 
                 7.1 
               
               
                   
                 Prostate Margin (OD04720-02) 
                 1.7 
                 11.3 
               
               
                   
                 Normal Lung 
                 9.2 
                 7.2 
               
               
                   
                 Lung Met to Muscle (ODO4286) 
                 0.7 
                 0.7 
               
               
                   
                 Muscle Margin (ODO4286) 
                 11.3 
                 12.5 
               
               
                   
                 Lung Malignant Cancer (OD03126) 
                 7.9 
                 4.7 
               
               
                   
                 Lung Margin (OD03126) 
                 6.4 
                 7.5 
               
               
                   
                 Lung Cancer (OD04404) 
                 3.0 
                 3.8 
               
               
                   
                 Lung Margin (OD04404) 
                 2.6 
                 2.8 
               
               
                   
                 Lung Cancer (OD04565) 
                 1.8 
                 3.4 
               
               
                   
                 Lung Margin (OD04565) 
                 3.6 
                 2.8 
               
               
                   
                 Lung Cancer (OD04237-01) 
                 22.5 
                 17.3 
               
               
                   
                 Lung Margin (OD04237-02) 
                 3.5 
                 4.5 
               
               
                   
                 Ocular Mel Met to Liver (ODO4310) 
                 2.1 
                 4.1 
               
               
                   
                 Liver Margin (ODO4310) 
                 1.2 
                 1.2 
               
               
                   
                 Melanoma Metastasis 
                 2.5 
                 1.7 
               
               
                   
                 Lung Margin (OD04321) 
                 5.3 
                 3.3 
               
               
                   
                 Normal Kidney 
                 93.3 
                 100.0 
               
               
                   
                 Kidney Ca, Nuclear grade 2 (OD04338) 
                 55.9 
                 92.7 
               
               
                   
                 Kidney Margin (OD04338) 
                 37.9 
                 36.6 
               
               
                   
                 Kidney Ca Nuclear grade 1/2 (OD04339) 
                 67.4 
                 76.3 
               
               
                   
                 Kidney Margin (OD04339) 
                 25.3 
                 33.2 
               
               
                   
                 Kidney Ca, Clear cell type (OD04340) 
                 52.5 
                 43.5 
               
               
                   
                 Kidney Margin (OD04340) 
                 0.0 
                 35.6 
               
               
                   
                 Kidney Ca, Nuclear grade 3 (OD04348) 
                 5.0 
                 7.6 
               
               
                   
                 Kidney Margin (OD04348) 
                 20.7 
                 26.6 
               
               
                   
                 Kidney Cancer (OD04622-01) 
                 9.3 
                 7.3 
               
               
                   
                 Kidney Margin (OD04622-03) 
                 7.1 
                 10.2 
               
               
                   
                 Kidney Cancer (OD04450-01) 
                 27.0 
                 29.3 
               
               
                   
                 Kidney Margin (OD04450-03) 
                 34.2 
                 33.7 
               
               
                   
                 Kidney Cancer 8120607 
                 4.1 
                 3.3 
               
               
                   
                 Kidney Margin 8120608 
                 9.2 
                 12.8 
               
               
                   
                 Kidney Cancer 8120613 
                 2.2 
                 3.3 
               
               
                   
                 Kidney Margin 8120614 
                 7.3 
                 14.9 
               
               
                   
                 Kidney Cancer 9010320 
                 22.4 
                 26.4 
               
               
                   
                 Kidney Margin 9010321 
                 18.3 
                 26.8 
               
               
                   
                 Normal Uterus 
                 9.6 
                 8.6 
               
               
                   
                 Uterine Cancer 064011 
                 2.7 
                 2.6 
               
               
                   
                 Normal Thyroid 
                 5.1 
                 5.3 
               
               
                   
                 Thyroid Cancer 
                 39.2 
                 44.1 
               
               
                   
                 Thyroid Cancer A302152 
                 30.8 
                 24.5 
               
               
                   
                 Thyroid Margin A302153 
                 3.3 
                 3.6 
               
               
                   
                 Normal Breast 
                 5.0 
                 4.5 
               
               
                   
                 Breast Cancer 
                 0.8 
                 1.7 
               
               
                   
                 Breast Cancer (OD04590-01) 
                 9.7 
                 7.6 
               
               
                   
                 Breast Cancer Mets (OD04590-03) 
                 26.1 
                 33.4 
               
               
                   
                 Breast Cancer Metastasis 
                 3.4 
                 4.1 
               
               
                   
                 Breast Cancer 
                 3.3 
                 4.4 
               
               
                   
                 Breast Cancer 
                 7.2 
                 8.3 
               
               
                   
                 Breast Cancer 9100266 
                 3.1 
                 3.7 
               
               
                   
                 Breast Margin 9100265 
                 3.3 
                 3.9 
               
               
                   
                 Breast Cancer A209073 
                 8.2 
                 8.9 
               
               
                   
                 Breast Margin A209073 
                 16.2 
                 11.6 
               
               
                   
                 Normal Liver 
                 1.4 
                 0.9 
               
               
                   
                 Liver Cancer 
                 1.8 
                 5.1 
               
               
                   
                 Liver Cancer 1025 
                 1.3 
                 2.0 
               
               
                   
                 Liver Cancer 1026 
                 3.4 
                 2.4 
               
               
                   
                 Liver Cancer 6004-T 
                 1.6 
                 0.4 
               
               
                   
                 Liver Tissue 6004-N 
                 1.3 
                 1.0 
               
               
                   
                 Liver Cancer 6005-T 
                 0.0 
                 6.5 
               
               
                   
                 Liver Tissue 6005-N 
                 1.6 
                 0.3 
               
               
                   
                 Normal Bladder 
                 3.4 
                 9.5 
               
               
                   
                 Bladder Cancer 
                 10.7 
                 6.5 
               
               
                   
                 Bladder Cancer 
                 1.8 
                 2.1 
               
               
                   
                 Bladder Cancer (OD04718-01) 
                 1.7 
                 5.2 
               
               
                   
                 Bladder Normal Adjacent (OD04718-03) 
                 4.2 
                 6.3 
               
               
                   
                 Normal Ovary 
                 9.5 
                 7.4 
               
               
                   
                 Ovarian Cancer 
                 100.0 
                 95.3 
               
               
                   
                 Ovarian Cancer (OD04768-07) 
                 4.6 
                 7.6 
               
               
                   
                 Ovary Margin (OD04768-08) 
                 7.3 
                 5.7 
               
               
                   
                 Normal Stomach 
                 1.7 
                 3.8 
               
               
                   
                 Gastric Cancer 9060358 
                 2.1 
                 0.5 
               
               
                   
                 Stomach Margin 9060359 
                 1.6 
                 3.1 
               
               
                   
                 Gastric Cancer 9060395 
                 3.3 
                 3.1 
               
               
                   
                 Stomach Margin 9060394 
                 2.2 
                 3.3 
               
               
                   
                 Gastric Cancer 9060397 
                 11.0 
                 14.5 
               
               
                   
                 Stomach Margin 9060396 
                 2.8 
                 4.3 
               
               
                   
                 Gastric Cancer 064005 
                 2.2 
                 6.5 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2120, Run 149975659    
               
               
                   
                   Column B - Rel. Exp. (%) Ag2120, Run 150010138    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BKD 
               
             
            
               
                   
               
               
                   
               
               
                 Panel 4D 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Secondary Th1 act 
                 0.4 
               
               
                   
                 Secondary Th2 act 
                 0.8 
               
               
                   
                 Secondary Tr1 act 
                 3.1 
               
               
                   
                 Secondary Th1 rest 
                 3.4 
               
               
                   
                 Secondary Th2 rest 
                 1.5 
               
               
                   
                 Secondary Tr1 rest 
                 1.5 
               
               
                   
                 Primary Th1 act 
                 0.3 
               
               
                   
                 Primary Th2 act 
                 0.8 
               
               
                   
                 Primary Tr1 act 
                 0.4 
               
               
                   
                 Primary Th1 rest 
                 3.1 
               
               
                   
                 Primary Th2 rest 
                 5.5 
               
               
                   
                 Primary Tr1 rest 
                 0.6 
               
               
                   
                 CD45RA CD4 lymphocyte act 
                 1.3 
               
               
                   
                 CD45RO CD4 lymphocyte act 
                 2.4 
               
               
                   
                 CD8 lymphocyte act 
                 2.2 
               
               
                   
                 Secondary CD8 lymphocyte rest 
                 4.8 
               
               
                   
                 Secondary CD8 lymphocyte act 
                 2.4 
               
               
                   
                 CD4 lymphocyte none 
                 0.9 
               
               
                   
                 2ry Th1/Th2/Tr1 anti-CD95 CH11 
                 0.7 
               
               
                   
                 LAK cells rest 
                 7.2 
               
               
                   
                 LAK cells IL-2 
                 0.4 
               
               
                   
                 LAK cells IL-2 + IL-12 
                 2.8 
               
               
                   
                 LAK cells IL-2 + IFN gamma 
                 7.7 
               
               
                   
                 LAK cells IL-2 + IL-18 
                 4.1 
               
               
                   
                 LAK cells PMA/ionomycin 
                 3.2 
               
               
                   
                 NK Cells IL-2 rest 
                 2.3 
               
               
                   
                 Two Way MLR 3 day 
                 2.7 
               
               
                   
                 Two Way MLR 5 day 
                 4.0 
               
               
                   
                 Two Way MLR 7 day 
                 5.2 
               
               
                   
                 PBMC rest 
                 6.4 
               
               
                   
                 PBMC PWM 
                 5.2 
               
               
                   
                 PBMC PHA-L 
                 1.8 
               
               
                   
                 Ramos (B cell) none 
                 3.9 
               
               
                   
                 Ramos (B cell) ionomycin 
                 1.6 
               
               
                   
                 B lymphocytes PWM 
                 0.0 
               
               
                   
                 B lymphocytes CD40L and IL-4 
                 3.2 
               
               
                   
                 EOL-1 dbcAMP 
                 67.4 
               
               
                   
                 EOL-1 dbcAMP PMA/ionomycin 
                 56.6 
               
               
                   
                 Dendritic cells none 
                 6.0 
               
               
                   
                 Dendritic cells LPS 
                 15.5 
               
               
                   
                 Dendritic cells anti-CD40 
                 13.5 
               
               
                   
                 Monocytes rest 
                 46.0 
               
               
                   
                 Monocytes LPS 
                 4.9 
               
               
                   
                 Macrophages rest 
                 47.3 
               
               
                   
                 Macrophages LPS 
                 24.8 
               
               
                   
                 HUVEC none 
                 10.2 
               
               
                   
                 HUVEC starved 
                 23.8 
               
               
                   
                 HUVEC IL-1beta 
                 11.2 
               
               
                   
                 HUVEC IFN gamma 
                 10.1 
               
               
                   
                 HUVEC TNF alpha + IFN gamma 
                 4.1 
               
               
                   
                 HUVEC TNF alpha + IL4 
                 13.2 
               
               
                   
                 HUVEC IL-11 
                 8.1 
               
               
                   
                 Lung Microvascular EC none 
                 3.2 
               
               
                   
                 Lung Microvascular EC TNFalpha + IL-1beta 
                 2.4 
               
               
                   
                 Microvascular Dermal EC none 
                 0.0 
               
               
                   
                 Microsvasular Dermal EC TNFalpha + IL-1beta 
                 0.0 
               
               
                   
                 Bronchial epithelium TNFalpha + IL1beta 
                 3.1 
               
               
                   
                 Small airway epithelium none 
                 5.4 
               
               
                   
                 Small airway epithelium TNFalpha + IL-1beta 
                 3.0 
               
               
                   
                 Coronery artery SMC rest 
                 35.6 
               
               
                   
                 Coronery artery SMC TNFalpha + IL-1beta 
                 39.0 
               
               
                   
                 Astrocytes rest 
                 1.1 
               
               
                   
                 Astrocytes TNFalpha + IL-1beta 
                 0.9 
               
               
                   
                 KU-812 (Basophil) rest 
                 0.5 
               
               
                   
                 KU-812 (Basophil) PMA/ionomycin 
                 2.0 
               
               
                   
                 CCD1106 (Keratinocytes) none 
                 0.9 
               
               
                   
                 CCD1106 (Keratinocytes) TNFalpha + IL-1beta 
                 2.6 
               
               
                   
                 Liver cirrhosis 
                 5.5 
               
               
                   
                 Lupus kidney 
                 9.3 
               
               
                   
                 NCI-H292 none 
                 2.0 
               
               
                   
                 NCI-H292 IL-4 
                 5.3 
               
               
                   
                 NCI-H292 IL-9 
                 3.8 
               
               
                   
                 NCI-H292 IL-13 
                 1.3 
               
               
                   
                 NCI-H292 IFN gamma 
                 3.4 
               
               
                   
                 HPAEC none 
                 9.0 
               
               
                   
                 HPAEC TNF alpha + IL-1 beta 
                 15.4 
               
               
                   
                 Lung fibroblast none 
                 1.7 
               
               
                   
                 Lung fibroblast TNF alpha + IL-1 beta 
                 0.0 
               
               
                   
                 Lung fibroblast IL-4 
                 2.8 
               
               
                   
                 Lung fibroblast IL-9 
                 1.6 
               
               
                   
                 Lung fibroblast IL-13 
                 1.0 
               
               
                   
                 Lung fibroblast IFN gamma 
                 1.4 
               
               
                   
                 Dermal fibroblast CCD1070 rest 
                 0.6 
               
               
                   
                 Dermal fibroblast CCD1070 TNF alpha 
                 2.3 
               
               
                   
                 Dermal fibroblast CCD1070 IL-1 beta 
                 5.4 
               
               
                   
                 Dermal fibroblast IFN gamma 
                 0.5 
               
               
                   
                 Dermal fibroblast IL-4 
                 3.0 
               
               
                   
                 IBD Colitis 2 
                 5.8 
               
               
                   
                 IBD Crohn&#39;s 
                 4.2 
               
               
                   
                 Colon 
                 5.8 
               
               
                   
                 Lung 
                 7.0 
               
               
                   
                 Thymus 
                 100.0 
               
               
                   
                 Kidney 
                 18.2 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2120, Run 149975626    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE BKE 
               
             
            
               
                   
               
               
                   
               
               
                 Panel CNS_1 
               
            
           
           
               
               
               
            
               
                   
                 Tissue Name 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 BA4 Control 
                 46.3 
               
               
                   
                 BA4 Control2 
                 42.9 
               
               
                   
                 BA4 Alzheimer&#39;s2 
                 5.1 
               
               
                   
                 BA4 Parkinson&#39;s 
                 38.4 
               
               
                   
                 BA4 Parkinson&#39;s2 
                 100.0 
               
               
                   
                 BA4 Huntington&#39;s 
                 53.6 
               
               
                   
                 BA4 Huntington&#39;s2 
                 4.3 
               
               
                   
                 BA4 PSP 
                 4.5 
               
               
                   
                 BA4 PSP2 
                 14.1 
               
               
                   
                 BA4 Depression 
                 11.8 
               
               
                   
                 BA4 Depression2 
                 3.5 
               
               
                   
                 BA7 Control 
                 45.4 
               
               
                   
                 BA7 Control2 
                 37.9 
               
               
                   
                 BA7 Alzheimer&#39;s2 
                 8.5 
               
               
                   
                 BA7 Parkinson&#39;s 
                 11.7 
               
               
                   
                 BA7 Parkinson&#39;s2 
                 54.3 
               
               
                   
                 BA7 Huntington&#39;s 
                 41.2 
               
               
                   
                 BA7 Huntington&#39;s2 
                 34.2 
               
               
                   
                 BA7 PSP 
                 36.1 
               
               
                   
                 BA7 PSP2 
                 21.2 
               
               
                   
                 BA7 Depression 
                 4.5 
               
               
                   
                 BA9 Control 
                 18.0 
               
               
                   
                 BA9 Control2 
                 76.3 
               
               
                   
                 BA9 Alzheimer&#39;s 
                 8.0 
               
               
                   
                 BA9 Alzheimer&#39;s2 
                 4.6 
               
               
                   
                 BA9 Parkinson&#39;s 
                 28.7 
               
               
                   
                 BA9 Parkinson&#39;s2 
                 55.5 
               
               
                   
                 BA9 Huntington&#39;s 
                 34.2 
               
               
                   
                 BA9 Huntington&#39;s2 
                 4.7 
               
               
                   
                 BA9 PSP 
                 11.6 
               
               
                   
                 BA9 PSP2 
                 3.8 
               
               
                   
                 BA9 Depression 
                 5.0 
               
               
                   
                 BA9 Depression2 
                 3.2 
               
               
                   
                 BA17 Control 
                 36.9 
               
               
                   
                 BA17 Control2 
                 62.0 
               
               
                   
                 BA17 Alzheimer&#39;s2 
                 2.9 
               
               
                   
                 BA17 Parkinson&#39;s 
                 13.4 
               
               
                   
                 BA17 Parkinson&#39;s2 
                 61.1 
               
               
                   
                 BA17 Huntington&#39;s 
                 27.9 
               
               
                   
                 BA17 Huntington&#39;s2 
                 8.4 
               
               
                   
                 BA17 Depression 
                 2.3 
               
               
                   
                 BA17 Depression2 
                 10.1 
               
               
                   
                 BA17 PSP 
                 20.0 
               
               
                   
                 BA17 PSP2 
                 10.5 
               
               
                   
                 Sub Nigra Control 
                 10.6 
               
               
                   
                 Sub Nigra Control2 
                 29.1 
               
               
                   
                 Sub Nigra Alzheimer&#39;s2 
                 5.8 
               
               
                   
                 Sub Nigra Parkinson&#39;s2 
                 20.6 
               
               
                   
                 Sub Nigra Huntington&#39;s 
                 21.5 
               
               
                   
                 Sub Nigra Huntington&#39;s2 
                 14.7 
               
               
                   
                 Sub Nigra PSP2 
                 3.6 
               
               
                   
                 Sub Nigra Depression 
                 3.2 
               
               
                   
                 Sub Nigra Depression2 
                 2.4 
               
               
                   
                 Glob Palladus Control 
                 1.8 
               
               
                   
                 Glob Palladus Control2 
                 7.8 
               
               
                   
                 Glob Palladus Alzheimer&#39;s 
                 6.4 
               
               
                   
                 Glob Palladus Alzheimer&#39;s2 
                 2.5 
               
               
                   
                 Glob Palladus Parkinson&#39;s 
                 34.4 
               
               
                   
                 Glob Palladus Parkinson&#39;s2 
                 3.1 
               
               
                   
                 Glob Palladus PSP 
                 5.2 
               
               
                   
                 Glob Palladus PSP2 
                 0.0 
               
               
                   
                 Glob Palladus Depression 
                 3.7 
               
               
                   
                 Temp Pole Control 
                 11.0 
               
               
                   
                 Temp Pole Control2 
                 40.1 
               
               
                   
                 Temp Pole Alzheimer&#39;s 
                 2.7 
               
               
                   
                 Temp Pole Alzheimer&#39;s2 
                 3.4 
               
               
                   
                 Temp Pole Parkinson&#39;s 
                 13.9 
               
               
                   
                 Temp Pole Parkinson&#39;s2 
                 20.7 
               
               
                   
                 Temp Pole Huntington&#39;s 
                 27.5 
               
               
                   
                 Temp Pole PSP 
                 2.5 
               
               
                   
                 Temp Pole PSP2 
                 3.7 
               
               
                   
                 Temp Pole Depression2 
                 1.8 
               
               
                   
                 Cing Gyr Control 
                 70.7 
               
               
                   
                 Cing Gyr Control2 
                 23.8 
               
               
                   
                 Cing Gyr Alzheimer&#39;s 
                 13.8 
               
               
                   
                 Cing Gyr Alzheimer&#39;s2 
                 7.7 
               
               
                   
                 Cing Gyr Parkinson&#39;s 
                 13.2 
               
               
                   
                 Cing Gyr Parkinson&#39;s2 
                 23.0 
               
               
                   
                 Cing Gyr Huntington&#39;s 
                 40.3 
               
               
                   
                 Cing Gyr Huntington&#39;s2 
                 12.9 
               
               
                   
                 Cing Gyr PSP 
                 7.6 
               
               
                   
                 Cing Gyr PSP2 
                 5.6 
               
               
                   
                 Cing Gyr Depression 
                 4.1 
               
               
                   
                 Cing Gyr Depression2 
                 4.6 
               
               
                   
                   
               
               
                   
                   Column A - Rel. Exp. (%) Ag2120, Run 171649389    
               
            
           
         
       
     
      Panel 1.3D Summary: Ag2120 Expression of this gene was highest in the cerebral cortex (CT value=29). Moderate expression was detected in all other regions of the brain except thalamus and substantia nigra, demonstrating that this gene is associated with normal brain homeostasis. This protein showed a brain-preferential expression, see write-up on Panel CNS.01 for discussion of utility. In addition, expression of this gene was down-regulated in CNS cancer cell lines. Over-expression of this gene was also detected in several lung cancer cell lines relative to normal control. Therefore, this gene is useful for the detection or treatment of CNS and lung cancers.  
      Panel 2D Summary: Ag2120 Expression of this gene in panel 2D revealed an association of expression in thyroid, breast and kidney cancers when compared to their respective normal adjacent tissues. Thus, therapeutic modulation of this gene with inhibitory monoclonal antibodies and/or small molecule therapeutics is useful in treatment of these diseases. In addition, the SC98428706_EXT gene might be useful as a marker for thyroid, breast and kidney cancers.  
      Panel 4D Summary: Ag 2120 This gene showed highest expression levels in the thymus. (CT value=31). The transcript was also expressed in eosinophils, monocytes, macrophages and coronary artery. It was down regulated in LPS-treated monocytes and to a lesser degree in LPS treated macrophages. Therefore, protein therapeutics (agonists or antagonists) designed against the protein encoded for by this transcript are useful for reducing the inflammatory process observed in asthma, emphysema, osteoarthritis and sepsis.  
      Panel CNS — 1 Summary: Ag2120 Insulin and insulin-like growth factors belong to a family of polypeptides essential for proper regulation of physiologic processes such as energy metabolism, cell proliferation, development, and differentiation. The insulin-like growth factors bind to IGF with high affinity and compete with the IGF receptor for IGF binding. Transgenic mice over expressing insulin-like growth factor binding proteins (IGFBPs) tend to show brain developmental abnormalities, suggesting a role for these proteins in neurodevelopment. Furthermore, treatment with glycosaminoglycans (which increases muscle re-innervation after motor neuron death) upregulates serum levels of both IGF and IGFBP. Thus, the novel IGFBP encoded by this gene is useful in the treatment of diseases such as ALS, multiple sclerosis, and peripheral nerve injury on the basis of its homology to other established IGFBPS. The expression profile of this gene shows that it is expressed preferentially in the brain, with highest levels in the cerebral cortex and hippocampus, two regions that are known to degenerate in Alzheimer&#39;s disease. Examination of the expression profile on Panel CNS.01 showed that most regions of both control and diseased brains express this protein; however the levels were decreased in the motor cortex in progressive supranuclear palsy and depression. Thus, this protein is of use in the treatment of Alzheimer&#39;s disease, progressive supranuclear palsy, and depression.  
     Example D  
     CG56008, NOV53  
     DETAILED DESCRIPTION  
      The present invention is based in part on the discovery that reducing the amount of LIV-1 mRNA present in tumor derived cells results in strongly reduced cell growth. The expression of this gene in tumor-derived cells was first defined using RTQPCR analysis.  
      The RTQPCR analysis of panel 1.3d reveals that this gene has a restricted high expression in 5 breast cancer cell lines, with the highest expression in MCF-7 breast cancer cells. This gene is present in normal tissues at low levels ( FIG. 1 ). The specific high expression in breast cancer cell lines indicates a role in breast cancer progression. This is further supported by the analysis of panel 2d that reveals how LIV-1 is upregulated specifically in breast cancers, comparing to the normal adjacent tissues ( FIG. 2 ). Based upon its profile, the expression of this gene could be of use as a marker for the presence of breast cancer in a subject, specifically in a subject blood. In addition, down-regulation of the activity of this gene, through the use of antibodies or antisense oligonucleotide, might be of use in the treatment of breast cancer.  
      The expression profiles of this gene on our RTQPCR panels indicate that this gene may be involved in regulating cancer cell proliferation and oncogenesis. To confirm whether LIV-1 expression is required for cell growth, we used antisense technology to examine the effect of decreasing LIV-1 gene expression on breast cancer cell proliferation. This technology has been used to asses the biological/therapeutic effect of reducing (knockdown) the expression of a gene (see Tamm et al., Lancet 2001 August 11;358(9280):489-97 for a review of the current use of this technology in the biomedical field)  
      As shown in  FIG. 4 , transfection of LIV-1 antisense oligonucleotide AS4 at 400 nM concentration inhibited T47D breast carcinoma cell growth more than 50% (P=0.000189), whereas transfection of scramble antisense control had little effect on cell growth. We observed less inhibitory effect with LIV-1 antisense oligo AS4 transfection in Ovcar4 cells in which the expression of LIV-1 is much lower (P=0.138366) ( FIG. 5 ). Knockdown of LIV-1 transcripts by antisense oligonucleotides was validated by RTQPCR. As shown in  FIG. 6 , transfection of antisense oligo AS4 resulted in 50% knockdown of LWV-1 expression at the mRNA level.  
      Therefore, our results suggested that LIV-1 expression is involved in cell proliferation. The inhibition of the activity of this gene through the use of antibodies or antisense oligonucleotides, mnight be of use in the treatment of breast cancer.  
     Example D1  
     Expression Analysis of LIV-1 in Various Tissues  
      RTOPCR Probe/Primer Information for LIV-1  
      RTQPCR Probe/Primers Set Ag2169  
                          (SEQ ID NO: 1603)                         Ag 2169 (F):           5′-CCCGAAAAGGCTTTATGTATTC-3′                         (SEQ ID NO: 1604)                     Ag 2169 (R):           5′-TGTCAGTAGCTTTGATGCATTG-3′                         (SEQ ID NO: 1605)                     Ag 2169 (P):           FAM-5′-CAGAAACACAAATGAAAATCCTCAGGA-3′-TAMRA          
 
     
       
         
           
               
             
               
                 TABLE D1 
               
             
            
               
                   
               
               
                   
               
               
                 RTQPCR results for Panel 1.3d. 
               
            
           
           
               
               
               
            
               
                   
                 Rel. Expr., % 
                 Rel. Expr., % 
               
               
                   
                 1.3dtm3016f —   
                 1.3Dtm3183f —   
               
               
                 Tissue Name 
                 ag2169 
                 ag2169 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Liver adenocarcinoma 
                 1.8 
                 2 
               
               
                 Pancreas 
                 1 
                 0.4 
               
               
                 Pancreatic ca. CAPAN 2 
                 1 
                 1 
               
               
                 Adrenal gland 
                 0.8 
                 0.6 
               
               
                 Thyroid 
                 2 
                 0.9 
               
               
                 Salivary gland 
                 1.2 
                 0.8 
               
               
                 Pituitary gland 
                 3.1 
                 2.2 
               
               
                 Brain (fetal) 
                 2.2 
                 1.7 
               
               
                 Brain (whole) 
                 2.6 
                 2.1 
               
               
                 Brain (amygdala) 
                 2 
                 1.1 
               
               
                 Brain (cerebellum) 
                 1.4 
                 0.9 
               
               
                 Brain (hippocampus) 
                 6.1 
                 4.4 
               
               
                 Brain (substantia nigra) 
                 0.5 
                 0.8 
               
               
                 Brain (thalamus) 
                 2.5 
                 2 
               
               
                 Cerebral Cortex 
                 2.8 
                 3.1 
               
               
                 Spinal cord 
                 1.6 
                 1.4 
               
               
                 glio/astro U87-MG 
                 1.2 
                 0.8 
               
               
                 glio/astro U-118-MG 
                 12 
                 9.3 
               
               
                 astro SW1783 
                 2.8 
                 3 
               
               
                 neuro; met SK-N-AS 
                 10.7 
                 6.7 
               
               
                 astro SF-539 
                 1.7 
                 1.5 
               
               
                 astro SNB-75 
                 2.8 
                 3.8 
               
               
                 glio SNB-19 
                 1 
                 0.9 
               
               
                 glio U251 
                 0.8 
                 0.8 
               
               
                 glio SF-295 
                 3.4 
                 3 
               
               
                 Heart (fetal) 
                 0.4 
                 0.5 
               
               
                 Heart 
                 0.2 
                 0.1 
               
               
                 Fetal Skeletal 
                 1.2 
                 1.4 
               
               
                 Skeletal muscle 
                 0.2 
                 0.2 
               
               
                 Bone marrow 
                 0.4 
                 0.2 
               
               
                 Thymus 
                 0.3 
                 0.3 
               
               
                 Spleen 
                 1.1 
                 0.8 
               
               
                 Lymph node 
                 0.8 
                 0.5 
               
               
                 Colorectal 
                 0.3 
                 0.2 
               
               
                 Stomach 
                 1.5 
                 0.8 
               
               
                 Small intestine 
                 0.9 
                 0.5 
               
               
                 Colon SW480 
                 1.6 
                 1.2 
               
               
                 Colon SW620(SW480 met) 
                 0.7 
                 0.5 
               
               
                 Colon HT29 
                 0.8 
                 0.6 
               
               
                 Colon HCT-116 
                 4.2 
                 3.1 
               
               
                 Colon CaCo-2 
                 0.9 
                 1.1 
               
               
                 Colon Ca tissue(ODO3866) 
                 1.3 
                 1.2 
               
               
                 Colon HCC-2998 
                 2.1 
                 1.6 
               
               
                 Gastric(liver met) NCI-N87 
                 2 
                 1.6 
               
               
                 Bladder 
                 1 
                 0.6 
               
               
                 Trachea 
                 1.6 
                 1.6 
               
               
                 Kidney 
                 0.5 
                 0.5 
               
               
                 Kidney (fetal) 
                 1.1 
                 0.8 
               
               
                 Renal 786-0 
                 2.6 
                 1.7 
               
               
                 Renal A498 
                 4.2 
                 3.2 
               
               
                 Renal RXF 393 
                 1.2 
                 0.8 
               
               
                 Renal ACHN 
                 2.6 
                 2.7 
               
               
                 Renal UO-31 
                 3.3 
                 2.4 
               
               
                 Renal TK-10 
                 2 
                 1.5 
               
               
                 Liver 
                 0.1 
                 0 
               
               
                 Liver (fetal) 
                 0.5 
                 0.3 
               
               
                 Liver (hepatoblast) HepG2 
                 1.5 
                 1.3 
               
               
                 Lung 
                 0.8 
                 0.6 
               
               
                 Lung (fetal) 
                 1.5 
                 1.5 
               
               
                 Lung (small cell) LX-1 
                 1 
                 0.7 
               
               
                 Lung (small cell) NCI-H69 
                 10 
                 6.3 
               
               
                 Lung (s. cell var.) SHP-77 
                 3.9 
                 4.9 
               
               
                 Lung (large cell)NCI-H460 
                 1.3 
                 1.2 
               
               
                 Lung (non-sm. cell) A549 
                 0.9 
                 0.6 
               
               
                 Lung (non-s. cell) NCI-H23 
                 5.4 
                 0 
               
               
                 Lung (non-s. cell) HOP-62 
                 1.8 
                 2 
               
               
                 Lung (non-s. cl) NCI-H522 
                 1.8 
                 1.2 
               
               
                 Lung (squam.) SW 900 
                 1.2 
                 0.8 
               
               
                 Lung (squam.) NCI-H596 
                 3.1 
                 3 
               
               
                 Mammary gland 
                 11.7 
                 10.4 
               
               
                 Breast (pl. ef) MCF-7 
                 100 
                 100 
               
               
                 Breast (pl.ef) MDA-MB-231 
                 2.5 
                 2.1 
               
               
                 Breast (pl.ef) T47D 
                 5.7 
                 3.3 
               
               
                 Breast BT-549 
                 4.5 
                 3.6 
               
               
                 Breast MDA-N 
                 2.6 
                 2.8 
               
               
                 Ovary 
                 2 
                 1.3 
               
               
                 Ovarian OVCAR-3 
                 2.2 
                 2 
               
               
                 Ovarian OVCAR-4 
                 0.3 
                 0.2 
               
               
                 Ovarian OVCAR-5 
                 0.6 
                 0.5 
               
               
                 Ovarian OVCAR-8 
                 1.6 
                 0.9 
               
               
                 Ovarian IGROV-1 
                 0.8 
                 0.5 
               
               
                 Ovarian (ascites) SK-OV-3 
                 4 
                 3.2 
               
               
                 Uterus 
                 1.1 
                 0.8 
               
               
                 Plancenta 
                 3.4 
                 2.1 
               
               
                 Prostate 
                 5.5 
                 4.6 
               
               
                 Prostate (bone met)PC-3 
                 2 
                 1.3 
               
               
                 Testis 
                 1.9 
                 1.6 
               
               
                 Melanoma Hs688(A).T 
                 4.8 
                 4.8 
               
               
                 Melanoma (met) Hs688(B).T 
                 6.2 
                 5.2 
               
               
                 Melanoma UACC-62 
                 0.3 
                 0.3 
               
               
                 Melanoma M14 
                 2.8 
                 2.6 
               
               
                 Melanoma LOX IMVI 
                 0.6 
                 0.4 
               
               
                 Melanoma (met) SK-MEL-5 
                 7.1 
                 5.1 
               
               
                 Adipose 
                 1.2 
                 0.8 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE D2 
               
             
            
               
                   
               
               
                   
               
               
                 RTQPCR results for Panel 2d. 
               
            
           
           
               
               
               
            
               
                   
                 Rel. Expr., % 
                 Rel. Expr., % 
               
               
                 Tissue Name 
                 2Dtm2969f_ag2169 
                 2dtm3017f_ag2169 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Normal Colon 
                 3.2 
                 3.1 
               
               
                 CCa 1 
                 0.6 
                 0.5 
               
               
                 CCa 1 Margin 
                 0.2 
                 0.4 
               
               
                 CCa 2 
                 0.1 
                 0.2 
               
               
                 CCa 2 Margin 
                 0.2 
                 0.1 
               
               
                 CCa 3 
                 0.2 
                 0.2 
               
               
                 CCa 3 Margin 
                 0.3 
                 0.2 
               
               
                 CCa 4 
                 1 
                 1.1 
               
               
                 CCa 4 Margin 
                 0.3 
                 0.4 
               
               
                 CCa 5 Metastasis 
                 1.6 
                 1.8 
               
               
                 CCa 5 Margin (Liver) 
                 0.5 
                 0.4 
               
               
                 CCa 6 Metastatsis 
                 0.2 
                 0.2 
               
               
                 CCa 6 Margin (Lung) 
                 0.4 
                 0.3 
               
               
                 Normal Prostate 
                 7.7 
                 7.9 
               
               
                 PCa 1 
                 15.1 
                 18.7 
               
               
                 PCa 1 Margin 
                 7.4 
                 7.9 
               
               
                 PCa 2 
                 3.4 
                 4 
               
               
                 PCa 2 Margin 
                 6.7 
                 7.3 
               
               
                 Normal Lung 
                 1.4 
                 1.6 
               
               
                 LCa 1 Metastasis 
                 1.4 
                 1.5 
               
               
                 LCa 1 Margin (muscle) 
                 0.7 
                 0.7 
               
               
                 LCa 2 
                 1.7 
                 2 
               
               
                 LCa 2 Margin 
                 1.1 
                 1.3 
               
               
                 LCa 3 
                 2 
                 2.6 
               
               
                 LCa 3 Margin 
                 1 
                 1.2 
               
               
                 LCa 4 
                 1 
                 1.1 
               
               
                 LCa 4 Margin 
                 0.5 
                 0.5 
               
               
                 LCa 5 
                 3.1 
                 3.4 
               
               
                 LCa 5 Margin 
                 0.9 
                 1 
               
               
                 Ocular Melanoma Metastasis 
                 3.7 
                 4.1 
               
               
                 Liver Margin 
                 0.2 
                 0.4 
               
               
                 Melanoma Metastasis 
                 3.5 
                 4 
               
               
                 Lung Margin 
                 0.9 
                 1.4 
               
               
                 Normal Kidney 
                 2.5 
                 3.1 
               
               
                 RCC 1 
                 2.8 
                 2.8 
               
               
                 RCC 1 Margin 
                 1.8 
                 1.9 
               
               
                 RCC 2 
                 0.7 
                 0.6 
               
               
                 RCC 2 Margin 
                 1.4 
                 1.4 
               
               
                 RCC 3 
                 2.5 
                 3.1 
               
               
                 RCC 3 Margin 
                 1.8 
                 1.9 
               
               
                 RCC 4 
                 1 
                 0.9 
               
               
                 RCC 4 Margin 
                 1.5 
                 1.7 
               
               
                 RCC 5 
                 0.9 
                 0.9 
               
               
                 RCC 5 Margin 
                 0.2 
                 0.1 
               
               
                 RCC 6 
                 1.1 
                 1 
               
               
                 RCC 6 Margin 
                 1.4 
                 1.5 
               
               
                 RCC 7 
                 0.5 
                 0.4 
               
               
                 RCC 7 Margin 
                 0.3 
                 0.2 
               
               
                 RCC 8 
                 0.4 
                 0.4 
               
               
                 RCC 8 Margin 
                 0.2 
                 0.2 
               
               
                 RCC 9 
                 0.8 
                 0.9 
               
               
                 RCC 9 Margin 
                 0.5 
                 0.6 
               
               
                 Normal Uterus 
                 0 
                 0.4 
               
               
                 UtCa 
                 1.8 
                 1.9 
               
               
                 Normal Thyroid 
                 1.4 
                 1.8 
               
               
                 ThyCa 1 
                 1.7 
                 1.9 
               
               
                 ThyCa 2 
                 0.9 
                 0.9 
               
               
                 ThyCa 2 Margin 
                 1.5 
                 1.5 
               
               
                 Normal Breast 
                 3.9 
                 4.9 
               
               
                 BCa 1 
                 19.8 
                 26.2 
               
               
                 BCa 2 
                 46.7 
                 45.7 
               
               
                 BCa 3 Metastasis 
                 43.2 
                 57.8 
               
               
                 BCa 4 Metastasis 
                 100 
                 100 
               
               
                 BCa 5 
                 2.4 
                 2.7 
               
               
                 BCa 6 
                 2.5 
                 2.3 
               
               
                 BCa 7 
                 41.2 
                 45.7 
               
               
                 BCa 7 Margin 
                 5 
                 5.7 
               
               
                 BCa 8 
                 4 
                 5.4 
               
               
                 BCa 8 Margin 
                 4.1 
                 6.8 
               
               
                 Normal Liver 
                 0.2 
                 0.3 
               
               
                 HCC 1 
                 0.2 
                 0.2 
               
               
                 HCC 2 
                 0.2 
                 0.1 
               
               
                 HCC 3 
                 0.3 
                 0.2 
               
               
                 HCC 4 
                 0.2 
                 0.2 
               
               
                 HCC 4 Margin 
                 0.5 
                 0.5 
               
               
                 HCC 5 
                 0.2 
                 0.2 
               
               
                 HCC 5 Margin 
                 0 
                 0 
               
               
                 Normal Bladder 
                 1.5 
                 1.4 
               
               
                 TCC 1 
                 0.3 
                 0.2 
               
               
                 TCC 2 
                 1.7 
                 1.8 
               
               
                 TCC 3 
                 3 
                 3.3 
               
               
                 TCC 3 Margin 
                 2.9 
                 1.4 
               
               
                 Normal Ovary 
                 0.3 
                 0.3 
               
               
                 OVCa 1 
                 3.3 
                 3 
               
               
                 OVCa 2 
                 3.1 
                 3.1 
               
               
                 OVCa 2 Margin 
                 0.4 
                 0.5 
               
               
                 Normal Stomach 
                 0.5 
                 0.5 
               
               
                 GaCa 1 
                 0.2 
                 0.2 
               
               
                 GaCa 1 Margin 
                 0.4 
                 0.4 
               
               
                 GaCa 2 
                 0.8 
                 0.7 
               
               
                 GaCa 2 Margin 
                 0.5 
                 0.5 
               
               
                 GaCa 3 
                 1 
                 0.9 
               
               
                 GaCa 3 Margin 
                 0.1 
                 0.1 
               
               
                 GaCa 4 
                 1 
                 0.8 
               
               
                   
               
            
           
         
       
     
     Example D2  
     Antisense knockdown of LIV-1 mRNA in High-expressing and Low-expressing Tumor-derived Cell Lines  
      Five oligonucleotides were designed and synthesized as mixed-backbone oligonucleotides containing modified phosphorothioate segments at 5′ and 3′ ends and 2′-O-methyl RNA oligoribonucleotide segments located in the middle. The purity of the oligonucleotides was confirmed by Masspectrophometry. The oligonucleotide sequences for LIV-1 are: ASI: 5′ GATCCAGGCTCTGTCACTCAC 3′ (SEQ ID NO: 1606) (complementary to the sequence located in 5′ UTR of LIV-1). AS2: 5′ ATTATGGGATCAGCGTTC 3′ (SEQ ID NO: 1607) (complementary to the sequence surrounding ATG start codon). AS3: 5′ AGGCTTAAGATGACCACTRG 3′ (complementary to the sequence 3′ next to AS2). AS4: 5′ GTGGTGCTCGTIFCGAACAGT 3′ (SEQ ID NO: 1608) (complementary to the sequence in the middle of SLPI ORF). AS5: 5° CTGGGTCTTAGTCCGTGGCA 3′ (SEQ ID NO: 1609) (complementary to the sequence flanking the 3′ stop codon). 10,000 cells were seeded in each well of 96 well plate in compelete medium 24 hr before transfection to reach 50% confluency on the day of transfection. Oligonucleotides were diluted with Optimen to 100 and 400 nM, and mixed with Oligofectamine (Invitrogen) according to manufecture&#39;s instructions. Cells were washed with serum-free medium. The oligo and lipisome mixture were then added to cells. After 4 hr incubation period, serum were added back to cells. Readout assays were performed 24 and 48 hr after transfection. CellTiter 96Aqueous Non-Radioactive Cell Porliferation Assay Kit from Promega was used to determine the number of viable cells in proliferation assay. Briefly, 20 μl of combined MTS/PMS solution were diluted with 100 μl complete medium, and added to each well of the 96 well plate. After 1 hr incubation at 37° C., the absorbance at 490 nm was recorded using an ELISA plate reader.  
       FIG. 2 . Antisense Knockdown of LIV-1 Inhibits T47D Cell Growth.  
      Breast cancer cell line T47D were transfected with 5 LIV-1 antisense oligonucleotides either individually or in the combinations as indicated. 72 hr after transfection, MTS assay was performed. The experiment was repeated twice with similar results. The representative data is shown. Asterisk indicates statistically significant difference on Student&#39;s 2-samples t test assuming unequal variances. P value for knockdown with AS4 comparing to scramble control at 400 nM is 0.000189.  
       FIG. 3 . Antisense Knockdown of LIV-1 Onhibits Ovcar-4 Cell Growth.  
      Ovarian cancer cell line Ovcar4 were transfected with LWV-1 antisense oligonucleotides either individually or in the combinations as indicated. 72 hr after transfection, MTS assay was performed. Asterisk indicates statistically significant difference on Student&#39;s 2-samples t test assuming unequal variances. P value for knockdown with AS4 comparing to scramble control at 400 nM is 0.138366.  
       FIG. 4 . RTOPCR Validation of Knockdown of LIV-1 Expression at mRNA Level in T47D Breast Cancer Cell Line.  
      T47D cells were transfected with LIV-1 antisense oligonucleotides in the combinations as indicated. 24 hr after transfection, cells were lysed in cell lysis buffer, and total RNA was isolated using RNAeasy kit from Qiagen. After DNAse digestion, cDNA was synthesized using Superscript II reverse transcriptase (BRL). RTQ-PCR analysis was performed according to the standard RTQPCR operation procedures.  
     Other Embodiments  
      Although particular embodiments are disclosed herein in detail, this is done by way of example for purposes of illustration only, and is not intended to be limiting with respect to the scope of the appended claims, which follow. In particular, it is contemplated by the inventors that various substitutions, alterations, and modifications will be made to the invention without departing from the spirit and scope of the invention as defined by the claims. The choice of nucleic acid starting material, clone of interest, or library type is believed to be a matter of routine for a person of ordinary skill in the art with knowledge of the embodiments described herein. Other aspects, advantages, and modifications considered to be within the scope of the following claims. The claims presented are representative of the inventions disclosed herein. Other, unclaimed inventions are also contemplated. Applicants reserve the right to pursue such inventions in later claims.