Patent Publication Number: US-6670464-B1

Title: Nucleic acids containing single nucleotide polymorphisms and methods of use thereof

Description:
RELATED APPLICATIONS 
     This application claims the benefit of the U.S. Provisional Application No. 60/109,024, filed Nov. 17, 1998 which is incorporated herein by reference in its entirety. 
    
    
     BACKGROUND OF THE INVENTION 
     Sequence polymorphism-based analysis of nucleic acid sequences has lead to novel approaches for determining the identity and relatedness of individuals. The approach is generally based on alterations in nucleic acid sequences between related individuals. This analysis has been widely used in a variety of genetic, diagnostic, and forensic applications. For example, polymorphism analyses are used in identity and paternity analysis, and in genetic mapping studies. 
     Several different types of polymorphisms in nucleic acid have been described. One such type of variation is a restriction fragment length polymorphism (RFLP). RFLPS can create or delete a recognition sequence for a restriction endonuclease in one nucleic acid relative to a second nucleic acid. The result of the variation is in an alteration the relative length of restriction enzyme generated DNA fragments in the two nucleic acids. 
     Other polymorphisms take the form of short tandem repeats (STR) sequences, which are also referred to as variable numbers of tandem repeat (VNTR) sequences. STR sequences typically that include tandem repeats of 2, 3, or 4 nucleotide sequences that are present in a nucleic acid from one individual but absent from a second, related individual at the corresponding genomic location. 
     Other polymorphisms take the form of single nucleotide variations, termed single nucleotide polymorphisms (SNPs), between individuals. A SNP can, in some instances, be referred to as a “cSNP” to denote that the nucleotide sequence containing the SNP originates as a cDNA. 
     SNPs can arise in several ways. A single nucleotide polymorphism may arise due to a substitution of one nucleotide for another at the polymorphic site. Substitutions can be transitions or transversions. A transition is the replacement of one purine nucleotide by another purine nucleotide, or one pyrimidine by another pyrimidine. A transversion is the replacement of a purine by a pyrimidine, or the converse. 
     Single nucleotide polymorphisms can also arise from a deletion of a nucleotide or an insertion of a nucleotide relative to a reference allele. Thus, the polymorphic site is a site at which one allele bears a gap with respect to a single nucleotide in another allele. Some SNPs occur within, or near genes. One such class includes SNPs falling within regions of genes encoding for a polypeptide product. These SNPs may result in an alteration of the amino acid sequence of the polypeptide product and give rise to the expression of a defective or other variant protein. Such variant products can, in some cases result in a pathological condition, e.g., genetic disease. Examples of genes in which a polymorphism within a coding sequence gives rise to genetic disease include sickle cell anemia and cystic fibrosis. Other SNPs do not result in alteration of the polypeptide product. Of course, SNPs can also occur in noncoding regions of genes. 
     SNPs tend to occur with great frequency and are spaced uniformly throughout the genome. The frequency and uniformity of SNPs means that there is a greater probability that such a polymorphism will be found in close proximity to a genetic locus of interest. 
     SUMMARY OF THE INVENTION 
     The invention is based in part on the discovery of novel single nucleotide polymorphisms (SNPs) in regions of human DNA. 
     Accordingly, in one aspect, the invention provides an isolated polynucleotide which includes one or more of the SNPs described herein. The polynucleotide can be, e.g., a nucleotide sequence which includes one or more of the polymorphic sequences shown in Table 1 (SEQ ID NOS: 1-1192) and which includes a polymorphic sequence, or a fragment of the polymorphic sequence, as long as it includes the polymorphic site. The polynucleotide may alternatively contain a nucleotide sequence which includes a sequence complementary to one or more of the sequences (SEQ ID NOS: 1-1192), or a fragment of the complementary nucleotide sequence, provided that the fragment includes a polymorphic site in the polymorphic sequence. 
     The polynucleotide can be, e.g., DNA or RNA, and can be between about 10 and about 100 nucleotides, e.g, 10-90, 10-75, 10-51, 10-40, or 10-30, nucleotides in length. 
     In some embodiments, the polymorphic site in the polymorphic sequence includes a nucleotide other than the nucleotide listed in Table 1, column 5 for the polymorphic sequence, e.g., the polymorphic site includes the nucleotide listed in Table 1, column 6 for the polymorphic sequence. 
     In other embodiments, the complement of the polymorphic site includes a nucleotide other than the complement of the nucleotide listed in Table 1, column 5 for the complement of the polymorphic sequence, e.g., the complement of the nucleotide listed in Table 1, column 6 for the polymorphic sequence. 
     In some embodiments, the polymorphic sequence is associated with a polypeptide related to one of the protein families disclosed herein. For example, the nucleic acid may be associated with a polypeptide related to angiopoietin, 4-hydroxybutyrate dehydrogenase, or any of the other proteins identified in Table 1, column 10. 
     In another aspect, the invention provides an isolated allele-specific oligonucleotide that hybridizes to a first polynucleotide containing a polymorphic site. The first polynucleotide can be, e.g., a nucleotide sequence comprising one or more polymorphic sequences (SEQ ID NOS:1-1192), provided that the polymorphic sequence includes a nucleotide other than the nucleotide recited in Table 1, column 5 for the polymorphic sequence. Alternatively, the first polynucleotide can be a nucleotide sequence that is a fragment of the polymorphic sequence, provided that the fragment includes a polymorphic site in the polymorphic sequence, or a complementary nucleotide sequence which includes a sequence complementary to one or more polymorphic sequences (SEQ ID NOS:1-1192), provided that the complementary nucleotide sequence includes a nucleotide other than the complement of the nucleotide recited in Table 1, column 5. The first polynucleotide may in addition include a nucleotide sequence that is a fragment of the complementary sequence, provided that the fragment includes a polymorphic site in the polymorphic sequence. 
     In some embodiments, the oligonucleotide does not hybridize under stringent conditions to a second polynucleotide. The second polynucleotide can be, e.g., (a) a nucleotide sequence comprising one or more polymorphic sequences (SEQ ID NOS:1-1192), wherein the polymorphic sequence includes the nucleotide listed in Table 1, column 5 for the polymorphic sequence; (b) a nucleotide sequence that is a fragment of any of the polymorphic sequences; (c) a complementary nucleotide sequence including a sequence complementary to one or more polymorphic sequences (SEQ ID NOS:1-1192), wherein the polymorphic sequence includes the complement of the nucleotide listed in Table 1, column 5; and (d) a nucleotide sequence that is a fragment of the complementary sequence, provided that the fragment includes a polymorphic site in the polymorphic sequence. 
     The oligonucleotide can be, e.g., between about 10 and about 100 bases in length. In some embodiments, the oligonucleotide is between about 10 and 75 bases, 10 and 51 bases, 10 and about 40 bases, or about 15 and 30 bases in length. 
     The invention also provides a method of detecting a polymorphic site in a nucleic acid. The method includes contacting the nucleic acid with an oligonucleotide that hybridizes to a polymorphic sequence selected from the group consisting of SEQ ID NOS: 1-1192, or its complement, provided that the polymorphic sequence includes a nucleotide other than the nucleotide recited in Table 1, column 5 for the polymorphic sequence, or the complement includes a nucleotide other than the complement of the nucleotide recited in Table 1, column 5. The method also includes determining whether the nucleic acid and the oligonucleotide hybridize. Hybridization of the oligonucleotide to the nucleic acid sequence indicates the presence of the polymorphic site in the nucleic acid. 
     In preferred embodiments, the oligonucleotide does not hybridize to the polymorphic sequence when the polymorphic sequence includes the nucleotide recited in Table 1, column 5 for the polymorphic sequence, or when the complement of the polymorphic sequence includes the complement of the nucleotide recited in Table 1, column 5 for the polymorphic sequence. 
     The oligonucleotide can be, e.g., between about 10 and about 100 bases in length. In some embodiments, the oligonucleotide is between about 10 and 75 bases, 10 and 51 bases, 10 and about 40 bases, or about 15 and 30 bases in length. 
     In some embodiments, the polymorphic sequence identified by the oligonucleotide is associated with a nucleic acid encoding polypeptide related to one of the protein families disclosed herein, the polymorphic sequence is associated with a polypeptide related to one of the protein families disclosed herein. For example, the nucleic acid may be associated with a polypeptide related to angiopoietin, 4-hydroxybutyrate dehydrogenase, or any of the other proteins identified in Table 1, column 10. 
     In a further aspect, the invention provides a method of determining the relatedness of a first and second nucleic acid. The method includes providing a first nucleic acid and a second nucleic acid and contacting the first nucleic acid and the second nucleic acid with an oligonucleotide that hybridizes to a polymorphic sequence selected from the group consisting of SEQ ID NOS: 1-1192, or its complement, provided that the polymorphic sequence includes a nucleotide other than the nucleotide recited in Table 1, column 5 for the polymorphic sequence, or the complement includes a nucleotide other than the complement of the nucleotide recited in Table 1, column 5. The method also includes determining whether the first nucleic acid and the second nucleic acid hybridize to the oligonucleotide, and comparing hybridization of the first and second nucleic acids to the oligonucleotide. Hybridization of first and second nucleic acids to the nucleic acid indicates the first and second subjects are related. 
     In preferred embodiments, the oligonucleotide does not hybridize to the polymorphic sequence when the polymorphic sequence includes the nucleotide recited in Table 1, column 5 for the polymorphic sequence, or when the complement of the polymorphic sequence includes the complement of the nucleotide recited in Table 1, column 5 for the polymorphic sequence. 
     The oligonucleotide can be, e.g., between about 10 and about 100 bases in length. In some embodiments, the oligonucleotide is between about 10 and 75 bases, 10 and 51 bases, 10 and about 40 bases, or about 15 and 30 bases in length. 
     The method can be used in a variety of applications. For example, the first nucleic acid may be isolated from physical evidence gathered at a crime scene, and the second nucleic acid may be obtained is a person suspected of having committed the crime. Matching the two nucleic acids using the method can establishing whether the physical evidence originated from the person. 
     In another example, the first sample may be from a human male suspected of being the father of a child and the second sample may be from a child. Establishing a match using the described method can establishing whether the male is the father of the child. 
     In another aspect, the method includes determining if a sequence polymorphism is the present in a subject, such as a human. The method includes providing a nucleic acid from the subject and contacting the nucleic acid with an oligonucleotide that hybridizes to a polymorphic sequence selected from the group consisting of SEQ ID NOS: 1-1192, or its complement, provided that the polymorphic sequence includes a nucleotide other than the nucleotide recited in Table 1, column 5 for said polymorphic sequence, or the complement includes a nucleotide other than the complement of the nucleotide recited in Table 1, column 5. Hybridization between the nucleic acid and the oligonucleotide is then determined. Hybridization of the oligonucleotide to the nucleic acid sequence indicates the presence of the polymorphism in said subject. 
     In another aspect, the invention provides an isolated polypeptide comprising a polymorphic site at one or more amino acid residues, and wherein the protein is encoded by a polynucleotide including one of the polymorphic sequences SEQ ID NOS:1-1192, or their complement, provided that the polymorphic sequence includes a nucleotide other than the nucleotide recited in Table 1, column 5 for the polymorphic sequence, or the complement includes a nucleotide other than the complement of the nucleotide recited in Table 1, column 5. 
     The polypeptide can be, e.g., related to one of the protein families disclosed herein. For example, polypeptide can be related to angiopoietin, 4-hydroxybutyrate dehydrogenase, ATP-dependent RNA helicase, MHC Class I histocompatibility antigen, or phosphoglycerate kinase. 
     In some embodiments, the polypeptide is translated in the same open reading frame as is a wild type protein whose amino acid sequence is identical to the amino acid sequence of the polymorphic protein except at the site of the polymorphism. 
     In some embodiments, the polypeptide encoded by the polymorphic sequence, or its complement, includes the nucleotide listed in Table 1, column 6 for the polymorphic sequence, or the complement includes the complement of the nucleotide listed in Table 1, column 6. 
     The invention also provides an antibody that binds specifically to a polypeptide encoded by a polynucleotide comprising a nucleotide sequence encoded by a polynucleotide selected from the group consisting of polymorphic sequences SEQ ID NOS:1-1192, or its complement. The polymorphic sequence includes a nucleotide other than the nucleotide recited in Table 1, column 5 for the polymorphic sequence, or the complement includes a nucleotide other than the complement of the nucleotide recited in Table 1, column 5. 
     In some embodiments, the antibody binds specifically to a polypeptide encoded by a polymorphic sequence which includes the nucleotide listed in Table 1, column 6 for the polymorphic sequence. 
     Preferably, the antibody does not bind specifically to a polypeptide encoded by a polymorphic sequence which includes the nucleotide listed in Table 1, column 5 for the polymorphic sequence. 
     The invention further provides a method of detecting the presence of a polypeptide having one or more amino acid residue polymorphisms in a subject. The method includes providing a protein sample from the subject and contacting the sample with the above-described antibody under conditions that allow for the formation of antibody-antigen complexes. The antibody-antigen complexes are then detected. The presence of the complexes indicates the presence of the polypeptide. 
     The invention also provides a method of treating a subject suffering from, at risk for, or suspected of, suffering from a pathology ascribed to the presence of a sequence polymorphism in a subject, e.g., a human, non-human primate, cat, dog, rat, mouse, cow, pig, goat, or rabbit. The method includes providing a subject suffering from a pathology associated with aberrant expression of a first nucleic acid comprising a polymorphic sequence selected from the group consisting of SEQ ID NOS:1-1192, or its complement, and treating the subject by administering to the subject an effective dose of a therapeutic agent. Aberrant expression can include qualitative alterations in expression of a gene, e.g., expression of a gene encoding a polypeptide having an altered amino acid sequence with respect to its wild-type counterpart. Qualitatively different polypeptides can include, shorter, longer, or altered polypeptides relative to the amino acid sequence of the wild-type polypeptide. Aberrant expression can also include quantitative alterations in expression of a gene. Examples of quantitative alterations in gene expression include lower or higher levels of expression of the gene relative to its wild-type counterpart, or alterations in the temporal or tissue-specific expression pattern of a gene. Finally, aberrant expression may also include a combination of qualitative and quantitative alterations in gene expression. 
     The therapeutic agent can include, e.g., second nucleic acid comprising the polymorphic sequence, provided that the second nucleic acid comprises the nucleotide present in the wild type allele. In some embodiments, the second nucleic acid sequence comprises a polymorphic sequence which includes nucleotide listed in Table 1, column 5 for the polymorphic sequence. 
     Alternatively, the therapeutic agent can be a polypeptide encoded by a polynucleotide comprising polymorphic sequence selected from the group consisting of SEQ ID NOS:1-1192, or by a polynucleotide comprising a nucleotide sequence that is complementary to any one of polymorphic sequences SEQ ID NOS:1-1192, provided that the polymorphic sequence includes the nucleotide listed in Table 1, column 6 for the polymorphic sequence. 
     The therapeutic agent may further include an antibody as herein described, or an oligonucleotide comprising a polymorphic sequence selected from the group consisting of SEQ ID NOS:1-1192, or by a polynucleotide comprising a nucleotide sequence that is complementary to any one of polymorphic sequences SEQ ID NOS:1-1192, provided that the polymorphic sequence includes the nucleotide listed in Table 1, column 5 or Table 1, column 6 for the polymorphic sequence, 
     In another aspect, the invention provides an oligonucleotide array comprising one or more oligonucleotides hybridizing to a first polynucleotide at a polymorphic site encompassed therein. The first polynucleotide can be, e.g., a nucleotide sequence comprising one or more polymorphic sequences (SEQ ID NOS:1-1192); a nucleotide sequence that is a fragment of any of the nucleotide sequence, provided that the fragment includes a polymorphic site in the polymorphic sequence; a complementary nucleotide sequence comprising a sequence complementary to one or more polymorphic sequences (SEQ ID NOS:1-1192); or a nucleotide sequence that is a fragment of the complementary sequence, provided that the fragment includes a polymorphic site in the polymorphic sequence. 
     In preferred embodiments, the he array comprises 10; 100; 1,000; 10,000; 100,000 or more oligonucleotides. 
     The invention also provides a kit comprising one or more of the herein-described nucleic acids. The kit can include, e.g., polynucleotide which includes one or more of the SNPs described herein. The polynucleotide can be, e.g., a nucleotide sequence which includes one or more of the polymorphic sequences shown in Table 1 (SEQ ID NOS: 1-1192) and which includes a polymorphic sequence, or a fragment of the polymorphic sequence, as long as it includes the polymorphic site. The polynucleotide may alternatively contain a nucleotide sequence which includes a sequence complementary to one or more of the sequences (SEQ ID NOS:1-1192), or a fragment of the complementary nucleotide sequence, provided that the fragment includes a polymorphic site in the polymorphic sequence. Alternatively, or in addition, the kit can include the invention provides an isolated allele-specific oligonucleotide that hybridizes to a first polynucleotide containing a polymorphic site. The first polynucleotide can be, e.g., a nucleotide sequence comprising one or more polymorphic sequences (SEQ ID NOS:1-1192), provided that the polymorphic sequence includes a nucleotide other than the nucleotide recited in Table 1, column 5 for the polymorphic sequence. Alternatively, the first polynucleotide can be a nucleotide sequence that is a fragment of the polymorphic sequence, provided that the fragment includes a polymorphic site in the polymorphic sequence, or a complementary nucleotide sequence which includes a sequence complementary to one or more polymorphic sequences (SEQ ID NOS:1-1192), provided that the complementary nucleotide sequence includes a nucleotide other than the complement of the nucleotide recited in Table 1, column 5. The first polynucleotide may in addition include a nucleotide sequence that is a fragment of the complementary sequence, provided that the fragment includes a polymorphic site in the polymorphic sequence. 
     Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In the case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and not intended to be limiting. 
     Other features and advantages of the invention will be apparent from the following detailed description and claims. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     The invention provides human SNPs in sequences which are transcribed, i.e., are cSNPs, and which have not been previously described. As is explained in more detail below, many SNPs have been identified in genes related to polypeptides of known function. If desired, SNPs associated with various polypeptides can be used together. For example, SNPs can be grouped according to whether they are derived from a nucleic acid encoding a polypeptide related to particular protein family or involved in a particular function. Thus, SNPs related to ATPase associated protein may be used together, as may SNPs associated with cadherin, or ephrin (EPH), or any of the other proteins recited in Table 1, column 10. Similarly, SNPs can be grouped according to the functions played by their gene products. Such functions include, structural proteins, proteins from which associated with metabolic pathways fatty acid metabolism, glycolysis, intermediary metabolism, calcium metabolism, proteases, and amino acid metabolism, etc. 
     The SNPs are shown in Table 1. Table 1 provides a summary of the polymorphic sequences disclosed herein. In the Table, a “SNP” is a polymorphic site embedded in a polymorphic sequence. The polymorphic site is occupied by a single nucleotide, which is the position of nucleotide variation between the wild type and polymorphic allelic sequences. The site is usually preceded by and followed by relatively highly conserved sequences of the allele (e.g., sequences that vary in less than 1/100 or 1/1000 members of the populations). Thus, a polymorphic sequence can include one or more of the following sequences: (1) a sequence having the nucleotide denoted in Table 1, column 5 at the polymorphic site in the polymorphic sequence: and (2) a sequence having a nucleotide other than the nucleotide denoted in Table 1, column 5 at the polymorphic site in the polymorphic sequence. An example of the latter sequence is a polymorphic sequence having the nucleotide denoted in Table 1, column 6 at the polymorphic site in the polymorphic sequence. 
     Nucleotide sequences for a referenced-polymorphic pair are presented in Table 1. The choice of designating one sequence of the cognate pair as a “reference” sequence and the second cognate of the pair as a “polymorphic” sequence is arbitrary. Each cSNP entry provides information concerning both the reference nucleotide sequence as well as the cognate polymorphic sequence occurring at a given polymorphic site. Each row of the Table provides this information for a given reference-polymorphism cognate pair. A reference to the sequence identifier number providing the sequences of both alleles is also provided. In addition, references to the SEQ ID NOS: giving the translated amino acid sequences are also given if appropriate. 
     Table 1 includes thirteen columns that provide descriptive information for each cSNP, each of which occupies one row in the Table. The column headings, and an explanation for each, are given below. 
     “SEQ ID” provides the cross-references to the two nucleotide SEQ ID NOS: for the cognate pair, which are numbered consecutively, and, as explained below, amino acid SEQ ID NOS: as well, in the Sequence Listing of the application. Conversely, each sequence entry in the Sequence Listing also includes a cross-reference to the CuraGen sequence ID, under the label “Accession number”. The first pair of SEQ ID NOS: given in the first column of each row of the Table is the SEQ ID NO: identifying the nucleic acid sequence for the polymorphism. If a polymorphism carries an entry for the amino acid portion of the row, a third SEQ ID NO: appears in parentheses in the column “Amino acid before” (see below) for the reference amino acid sequence, and a fourth SEQ ID NO: appears in parentheses in the column “Amino acid after” (see below) for the polymorphic amino acid sequence. The latter SEQ ID NOS: refer to amino acid sequences giving the cognate reference and polymorphic amino acid sequences that are the translation of the nucleotide polymorphism. If a polymorphism carries no entry for the protein portion of the row, only one pair SEQ ID NOS: is provided, in the first column. 
     “CuraGen sequence ID” provides CuraGen Corporation&#39;s accession number. 
     “Base pos. of SNP” gives the numerical position of the nucleotide in the nucleic acid at which the cSNP is found, as identified in this invention. 
     “Polymorphic sequence” provides a 51-base sequence with the polymorphic site at the 26 th  base in the sequence, as well as 25 bases from the reference sequence on the 5′ side and the 3′ side of the polymorphic site. The designation at the polymorphic site is enclosed in square brackets, and provides first, the reference nucleotide; second, a “slash (/)”; and third, the polymorphic nucleotide. In certain cases the polymorphism is an insertion or a deletion. In that case, the position that is “unfilled” (i.e., the reference or the polymorphic position) is indicated by the word “gap”. 
     “Base before” provides the nucleotide present in the reference sequence at the position at which the polymorphism is found. 
     “Base after” provides the altered nucleotide at the position of the polymorphism. “Amino acid before” provides the amino acid in the reference protein, if the polymorphism occurs in a coding region. This column also includes the SEQ ID NO: in parentheses for the translated reference amino acid sequence if the polymorphism occurs in a coding region. 
     “Amino acid after” provides the amino acid in the polymorphic protein, if the polymorphism occurs in a coding region. This column also includes the SEQ ID NO: in parentheses for the translated polymorphic amino acid sequence if the polymorphism occurs in a coding region. 
     “Type of change” provides information on the nature of the polymorphism. “SILENT-NONCODING” is used if the polymorphism occurs in a noncoding region of a nucleic acid. “SILENT-CODING” is used if the polymorphism occurs in a coding region of a nucleic acid of a nucleic acid and results in no change of amino acid in the translated polymorphic protein. “CONSERVATIVE” is used if the polymorphism occurs in a coding region of a nucleic acid and provides a change in which the altered amino acid falls in the same class as the reference amino acid. The classes are: 1) Aliphatic: Gly, Ala, Val, Leu, Ile; 2) Aromatic: Phe, Tyr, Trp; 3) Sulfur-containing: Cys, Met; 4) Aliphatic OH: Ser, Thr; 5) Basic: Lys, Arg, His; 6) Acidic: Asp, Glu, Asn, Gln; 7) Pro falls in none of the other classes; and 8) End defines a termination codon. 
     “NONCONSERVATIVE” is used if the polymorphism occurs in a coding region of a nucleic acid and provides a change in which the altered amino acid falls in a different class than the reference amino acid. 
     “FRAMESHIFT” relates to an insertion or a deletion. If the frameshift occurs in a coding region, the Table provides the translation of the frameshifted codons 3′ to the polymorphic site. 
     “Protein classification of CuraGen gene” provides a generic class into which the protein is classified. Approximately multiple classes of proteins were identified. The classes include the following: 
     Examples of possible disease correlations between the claimed SNPs with members of the genes of each classification are listed below for representative protein families. 
     Amylases 
     Amylase is responsible for endohydrolysis of 1,4-alpha-glucosidic linkages in oligosaccharides and polysaccharides. Variations in amylase gene may be indicative of delayed maturation and of various amylase producing neoplasms and carcinomas. 
     Amyloid 
     The serum amyloid A (SAA) proteins comprise a family of vertebrate proteins that associate predominantly with high-density lipoproteins (HDL). The synthesis of certain members of the family is greatly increased in inflammation. Prolonged elevation of plasma SAA levels, as in chronic inflammation, 15 results in a pathological condition, called amyloidosis, which affects the liver, kidney and spleen and which is characterized by the highly insoluble accumulation of SAA in these tissues. Amyloid selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Deposition of fibrillar amyloid proteins intraneuronally, as neurofibrillary tangles, extracellularly, as plaques and in blood vessels, is characteristic of both Alzheimer&#39;s disease and aged Down&#39;s syndrome. Amyloid deposition is also associated with type II diabetes mellitus. 
     Angiopoeitin 
     Members of the angiopoeitin/fibrinogen family have been shown to stimulate the generation of new blood vessels, inhibit the generation of new blood vessels, and perform several roles in blood clotting. This generation of new blood vessels, called angiogenesis, is also an essential step in tumor growth in order for the tumor to get the blood supply that it needs to expand. Variation in these genes may be predictive of any form of heart disease, numerous blood clotting disorders, stroke, hypertension and predisposition to tumor formation and metastasis. In particular, these variants may be predictive of the response to various antihypertensive drugs and chemotherapeutic and anti-tumor agents. 
     Apoptosis-Related Proteins 
     Active cell suicide (apoptosis) is induced by events such as growth factor withdrawal and toxins. It is controlled by regulators, which have either an inhibitory effect on programmed cell death (anti-apoptotic) or block the protective effect of inhibitors (pro-apoptotic). Many viruses have found a way of countering defensive apoptosis by encoding their own anti-apoptosis genes preventing their target-cells from dying too soon. Variants of apoptosis related genes may be useful in formulation of anti-aging drugs. 
     Cadherin, Cyclin, Polymerase, Oncogenes, Histones, Kinases 
     Members of the cell division/cell cycle pathways such as cyclins, many transcription factors and kinases, DNA polymerases, histones, helicases and other oncogenes play a critical role in carcinogenesis where the uncontrolled proliferation of cells leads to tumor formation and eventually metastasis. Variation in these genes may be predictive of predisposition to any form of cancer, from increased risk of tumor formation to increased rate of metastasis. In particular, these variants may be predictive of the response to various chemotherapeutic and anti-tumor agents. 
     Colony-Stimulating Factor-Related Proteins 
     Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. 
     Complement-Related Proteins 
     Complement proteins are immune associated cytotoxic agents, acting in a chain reaction to exterminate target cells to that were opsonized (primed) with antibodies, by forming a membrane attack complex (MAC). The mechanism of killing is by opening pores in the target cell membrane. Variations in 20 complement genes or their inhibitors are associated with many autoimmune disorders. Modified serum levels of complement products cause edemas of various tissues, lupus (SLE), vasculitis, glomerulonephritis, renal failure, hemolytic anemia, thrombocytopenia, and arthritis. They interfere with mechanisms of ADCC (antibody dependent cell cytotoxicity), severely impair immune competence and reduce phagocytic ability. Variants of complement genes may also be indicative of type I diabetes mellitus, meningitis neurological disorders such as Nemaline myopathy, Neonatal hypotonia, muscular disorders such as congenital myopathy and other diseases. 
     Cytochrome 
     The respiratory chain is a key biochemical pathway which is essential to all aerobic cells. There are five different cytochromes involved in the chain. These are heme bound proteins which serve as electron carriers. Modifications in these genes may be predictive of ataxia areflexia, dementia and myopathic and neuropathic changes in muscles. Also, association with various types of solid tumors. 
     Kinesins 
     Kinesins are tubulin molecular motors that function to transport organelles within cells and to move chromosomes along microtubules during cell division. Modifications of these genes may be indicative of neurological disorders such as Pick disease of the brain, tuberous sclerosis. 
     Cytokines, Interferon, Interleukin 
     Members of the cytokine families are known for their potent ability to stimulate cell growth and division even at low concentrations. Cytokines such as erythropoietin are cell-specific in their growth stimulation; erythropoietin is useful for the stimulation of the proliferation of erythroblasts. Variants in cytokines may be predictive for a wide variety of diseases, including cancer predisposition. 
     G-protein Coupled Receptors 
     G-protein coupled receptors (also called R7G) are an extensive group of hormones, neurotransmitters, odorants and light receptors which transduce extracellular signals by interaction with guanine nucleotide-binding (G) proteins. Alterations in genes coding for G-coupled proteins may be involved in and indicative of a vast number of physiological conditions. These include blood pressure regulation, renal dysfunctions, male infertility, dopamine associated cognitive, emotional, and endocrine functions, hypercalcemia, chondrodysplasia and osteoporosis, pseudohypoparathyroidism, growth retardation and dwarfism. 
     Thioesterases 
     Eukaryotic thiol proteases are a family of proteolytic enzymes which contain an active site cysteine. Catalysis proceeds through a thioester intermediate and is facilitated by a nearby histidine side chain; an asparagine completes the essential catalytic triad. Variants of thioester associated genes may be predictive of neuronal disorders and mental illnesses such as Ceroid Lipoffiscinosis, Neuronal 1, Infantile, Santavuori disease and more. 
     “Name of protein identified following a BLASTX analysis of the CuraGen sequence” provides the database reference for the protein found to resemble the novel reference-polymorphism cognate pair most closely. 
     “Similarity (pvalue) following a BLASTX analysis” provides the pvalue, a statistical measure from the BLASTX analysis that the polymorphic sequence is similar to, and therefore an allele of, the reference, or wild-type, sequence. In the present application, a cutoff of pvalue &gt;1×10 −50  (entered, for example, as 1.0E-50 in the Table) is used to establish that the reference-polymorphic cognate pairs are novel. A pvalue &lt;1×10 −50  defines proteins considered to be already known. 
     “Map location” provides any information available at the time of filing related to localization of a gene on a chromosome. 
     The polymorphisms are arranged in Table 1 in the following order: 
     SEQ ID NOS: 1 to 1112, in consecutive pairs, are SNPs that are silent; 
     SEQ ID NOS: 1113-1128, in consecutive pairs, are SNPs that lead to conservative amino acid changes; 
     SEQ ID NOS: 1129-1186, in consecutive pairs, are SNPs that lead to nonconservative amino acid changes; and 
     SEQ ID NOS: 1187-1192, in consecutive pairs, are SNPs that involve a gap. 
     With respect to the reference or wild-type sequence at the position of the polymorphism, the allelic cSNP introduces an additional nucleotide (an insertion) or deletes a nucleotide (a deletion). A SNP that involves a gap generates a frame shift. 
     Also presented in the sequence listing filed herewith are predicted amino acid sequences encoded by the polymorphic sequences shown in Table 1. SEQ ID NOS: 1193-1208, in consecutive pairs, are the amino acid sequences centered at the polymorphic amino acid residue for the protein products provided by SNPs that lead to conservative amino acid changes between the reference and the polymorphic sequences. 7 or 8 amino acids on either side of the polymorphic site are shown. The order in which these sequences appear mirrors the order of presentation of the cognate nucleotide sequences, and is set forth in Table 1. 
     SEQ ID NOS: 1209-1266, in consecutive pairs, are the amino acid sequences centered at the polymorphic amino acid residue for the protein products provided by SNPs that lead to nonconservative amino acid changes between the reference and the polymorphic sequences. 7 or 8 amino acids on either side of the polymorphic site are shown. The order in which these sequences appear mirrors the order of presentation of the cognate nucleotide sequences, and is set forth in the Table. 
     SEQ ID NOS: 1267-1272, in consecutive pairs, are the amino acid sequences centered at the polymorphic amino acid residue for the protein products provided by SNPs that lead to frameshift-induced amino acid changes between the reference and the polymorphic sequences. 7 or 8 amino acids on either side of the polymorphic site are shown. The order in which these sequences appear mirrors the order of presentation of the cognate nucleotide sequences, and is set forth in Table 1. 
     Provided herein are compositions which include, or are capable of detecting, nucleic acid sequences having these polymorphisms, as well as methods of using nucleic acids. 
     Identification of Individuals Carrying SNPs 
     Individuals carrying polymorphic alleles of the invention may be detected at either the DNA, the RNA, or the protein level using a variety of techniques that are well known in the art. Strategies for identification and detection are described in e.g., EP 730,663, EP 717,113, and PCT US97/02102. The present methods usually employ pre-characterized polymorphisms. That is, the genotyping location and nature of polymorphic forms present at a site have already been determined. The availability of this information allows sets of probes to be designed for specific identification of the known polymorphic forms. 
     Many of the methods described below require amplification of DNA from target samples. This can be accomplished by e.g., PCR. (1989), B. for detecting polymorphisms. See generally PCR Technology: Principles and Applications for DNA Amplification (ed. H. A. Erlich, Freeman Press, NY, N.Y., 1992); PCR Protocols: A Guide to Methods and Applications (eds. Innis, et al., Academic Press, San Diego, Calif., 1990); Mattila et al., Nucleic Acids Res. 19, 4967 (1991); Eckert et al., PCR Methods and Applications 1, 17 (1991); PCR (eds. McPherson et al., IRL Press, Oxford); and U.S. Pat. No. 4,683,202. 
     The phrase “recombinant protein” or “recombinantly produced protein” refers to a peptide or protein produced using non-native cells that do not have an endogenous copy of DNA able to express the protein. In particular, as used herein, a recombinantly produced protein relates to the gene product of a polymorphic allele, i.e., a “polymorphic protein” containing an altered amino acid at the site of translation of the nucleotide polymorphism. The cells produce the protein because they have been genetically altered by the introduction of the appropriate nucleic acid sequence. The recombinant protein will not be found in association with proteins and other subcellular components normally associated with the cells producing the protein. The terms “protein” and “polypeptide” are used interchangeably herein. 
     The phrase “substantially purified” or “isolated” when referring to a nucleic acid, peptide or protein, means that the chemical composition is in a milieu containing fewer, or preferably, essentially none, of other cellular components with which it is naturally associated. Thus, the phrase “isolated” or “substantially pure” refers to nucleic acid preparations that lack at least one protein or nucleic acid normally associated with the nucleic acid in a host cell. It is preferably in a homogeneous state although it can be in either a dry or aqueous solution. Purity and homogeneity are typically determined using analytical chemistry techniques such as gel electrophoresis or high performance liquid chromatography. Generally, a substantially purified or isolated nucleic acid or protein will comprise more than 80% of all macromolecular species present in the preparation. Preferably, the nucleic acid or protein is purified to represent greater than 90% of all macromolecular species present. More preferably the nucleic acid or protein is purified to greater than 95%, and most preferably the nucleic acid or protein is purified to essential homogeneity, wherein other macromolecular species are not detected by conventional analytical procedures. 
     The genomic DNA used for the diagnosis may be obtained from any nucleated cells of the body, such as those present in peripheral blood, urine, saliva, buccal samples, surgical specimen, and autopsy specimens. The DNA may be used directly or may be amplified enzymatically in vitro through use of PCR (Saiki et al.  Science  239:487-491 (1988)) or other in vitro amplification methods such as the ligase chain reaction (LCR) (Wu and Wallace  Genomics  4:560-569 (1989)), strand displacement amplification (SDA) (Walker et al.  Proc. Natl. Acad. Sci. U.S.A , 89:392-396 (1992)), self-sustained sequence replication (3SR) (Fahy et al. PCR Methods P&amp;J&amp; 1:25-33 (1992)), prior to mutation analysis. 
     The method for preparing nucleic acids in a form that is suitable for mutation detection is well known in the art. A “nucleic acid” is a deoxyribonucleotide or ribonucleotide polymer in either single-or double-stranded form, including known analogs of natural nucleotides unless otherwise indicated. The term “nucleic acids”, as used herein, refers to either DNA or RNA. “Nucleic acid sequence” or “polynucleotide sequence” refers to a single-stranded sequence of deoxyribonucleotide or ribonucleotide bases read from the 5′ end to the 3′ end. The direction of 5′ to 3′ addition of nascent RNA transcripts is referred to as the transcription direction; sequence regions on the DNA strand having the same sequence as the RNA and which are beyond the 5′ end of the RNA transcript in the 5′ direction are referred to as “upstream sequences”; sequence regions on the DNA strand having the same sequence as the RNA and which are beyond the 3′ end of the RNA transcript in the 3′ direction are referred to as “downstream sequences”. The term includes both self-replicating plasmids, infectious polymers of DNA or RNA and nonfunctional DNA or RNA. The complement of any nucleic acid sequence of the invention is understood to be included in the definition of that sequence. “Nucleic acid probes” may be DNA or RNA fragments. 
     The detection of polymorphisms in specific DNA sequences, can be accomplished by a variety of methods including, but not limited to, restriction-fragment-length-polymorphism detection based on allele-specific restriction-endonuclease cleavage (Kan and Dozy  Lancet  ii:910-912 (1978)), hybridization with allele-specific oligonucleotide probes (Wallace et al. Nucl. Acids Res. 6:3543-3557 (1978)), including immobilized oligonucleotides (Saiki et al.  Proc. Natl. Acad. SCI. USA , 86:6230-6234 (1969)) or oligonucleotide arrays (Maskos and Southern  Nucl. Acids Res  21:2269-2270 (1993)), allele-specific PCR (Newton et al.  Nucl Acids Res  17:2503-2516 (1989)), mismatch-repair detection (MRD) (Faham and Cox  Genome Res  5:474-482 (1995)), binding of MutS protein (Wagner et al.  Nucl Acids Res  23:3944-3948 (1995), denaturing-gradient gel electrophoresis (DGGE) (Fisher and Lerman et al.  Proc. Natl. Acad. Sci. U.S.A . 80:1579-1583 (1983)), single-strand-confirmation-polymorphism detection (Orita et al. Genomics 5:874-879 (1983)), RNAase cleavage at mismatched base-pairs (Myers et al.  Science  230:1242 (1985)), chemical (Cotton et al. Proc. Natl. w Sci. U.S.A, 8Z4397-4401 (1988)) or enzymatic (Youil et al. Proc. Natl. Acad. Sci. U.S.A. 92:87-91 (1995)) cleavage of heteroduplex DNA, methods based on allele specific primer extension (Syvanen et al.  Genomics  8:684-692 (1990)), genetic bit analysis (GBA) (Nikiforov et al. &amp;&amp;I  Acids  22:4167-4175 (1994)), the oligonucleotide-ligation assay (OLA) (Landegren et al. Science 241:1077 (1988)), the allele-specific ligation chain reaction (LCR) (Barrany Proc. Natl. Acad. Sci. U.S.A. 88:189-193 (1991)), gap-LCR (Abravaya et al.  Nucl Acids Res  23:675-682 (1995)), radioactive and/or fluorescent DNA sequencing using standard procedures well known in the art, and peptide nucleic acid (PNA) assays (Orum et al., Nucl. Acids Res, 21:5332-5356 (1993); Thiede et al.,  Nucl. Acids Res . 24:983-984 (1996)). 
     “Specific hybridization” or “selective hybridization” refers to the binding, or duplexing, of a nucleic acid molecule only to a second particular nucleotide sequence to which the nucleic acid is complementary, under suitably stringent conditions when that sequence is present in a complex mixture (e.g., total cellular DNA or RNA). “Stringent conditions” are conditions under which a probe will hybridize to its target subsequence, but to no other sequences. Stringent conditions are sequence-dependent and are different in different circumstances. Longer sequences hybridize specifically at higher temperatures than shorter ones. Generally, stringent conditions are selected such that the temperature is about 5° C. lower than the thermal melting point (Tm) for the specific sequence to which hybridization is intended to occur at a defined ionic strength and pH. The Tm is the temperature (under defined ionic strength, pH, and nucleic acid concentration) at which 50% of the target sequence hybridizes to the complementary probe at equilibrium. Typically, stringent conditions include a salt concentration of at least about 0.01 to about 1.0 M Na ion concentration (or other salts), at pH 7.0 to 8.3. The temperature is at least about 30° C. for short probes (e.g., 10 to 50 nucleotides). Stringent conditions can also be achieved with the addition of destabilizing agents such as formamide. For example, conditions of 5× SSPE (750 mM NaCl, 50 mM NaPhosphate, 5 mM EDTA, pH 7.4) and a temperature of 25-30° C. are suitable for allele-specific probe hybridizations. 
     “Complementary” or “target” nucleic acid sequences refer to those nucleic acid sequences which selectively hybridize to a nucleic acid probe. Proper annealing conditions depend, for example, upon a probe&#39;s length, base composition, and the number of mismatches and their position on the probe, and must often be determined empirically. For discussions of nucleic acid probe design and annealing conditions, see, for example, Sambrook et al., or  Current Protocols in Molecular Biology , F. Ausubel et al., ed., Greene Publishing and Wiley-Interscience, New York (1987). 
     A perfectly matched probe has a sequence perfectly complementary to a particular target sequence. The test probe is typically perfectly complementary to a portion of the target sequence. A “polymorphic” marker or site is the locus at which a sequence difference occurs with respect to a reference sequence. Polymorphic markers include restriction fragment length polymorphisms, variable number of tandem repeats (VNTR&#39;s), hypervariable regions, minisatellites, dinucleotide repeats, trinucleotide repeats, tetranucleotide repeats, simple sequence repeats, and insertion elements such as Alu. The reference allelic form may be, for example, the most abundant form in a population, or the first allelic form to be identified, and other allelic forms are designated as alternative, variant or polymorphic alleles. The allelic form occurring most frequently in a selected population is sometimes referred to as the “wild type” form, and herein may also be referred to as the “reference” form. Diploid organisms may be homozygous or heterozygous for allelic forms. A diallelic polymorphism has two distinguishable forms (i.e., base sequences), and a triallelic polymorphism has three such forms. 
     As use herein an “oligonucleotide” is a single-stranded nucleic acid ranging in length from 2 to about 60 bases. Oligonucleotides are often synthetic but can also be produced from naturally occurring polynucleotides. A probe is an oligonucleotide capable of binding to a target nucleic acid of complementary sequence through one or more types of chemical bonds, usually through complementary base pairing via hydrogen bond formation. Oligonucleotides probes are often between 5 and 60 bases, and, in specific embodiments, may be between 10-40, or 15-30 bases long. An oligonucleotide probe may include natural (i.e. A, G, C, or T) or modified bases (7-deazaguanosine, inosine, etc.). In addition, the bases in an oligonucleotide probe may be joined by a linkage other than a phosphodiester bond, such as a phosphoramidite linkage or a phosphorothioate linkage, or they may be peptide nucleic acids in which the constituent bases are joined by peptide bonds rather than by phosphodiester bonds, so long as it does not interfere with hybridization. 
     As used herein, the term “primer” refers to a single-stranded oligonucleotide which acts as a point of initiation of template-directed DNA synthesis under appropriate conditions (e.g., in the presence of four different nucleoside triphosphates and a polymerization agent, such as DNA polymerase, RNA polymerase or reverse transcriptase) in an appropriate buffer and at a suitable temperature. The appropriate length of a primer depends on the intended use of the primer, but typically ranges from 15 to 30 nucleotides. Short primer molecules generally require cooler temperatures to form sufficiently stable hybrid complexes with the template. A primer need not be perfectly complementary to the exact sequence of the template, but should be sufficiently complementary to hybridize with it. The term “primer site” refers to the sequence of the target DNA to which a primer hybridizes. The term “primer pair” refers to a set of primers including a 5′ (upstream) primer that hybridizes with the 5′ end of the DNA sequence to be amplified and a 3′ (downstream) primer that hybridizes with the complement of the 3′ end of the sequence to be amplified. 
     DNA fragments can be prepared, for example, by digesting plasmid DNA, or by use of PCR. Oligonucleotides for use as primers or probes are chemically synthesized by methods known in the field of the chemical synthesis of polynucleotides, including by way of non-limiting example the phosphoramidite method described by Beaucage and Carruthers,  Tetrahedron Lett  22:1859-1862 (1981) and the triester method provided by Matteucci, et al.,  J. Am. Chem. Soc ., 103:3185 (1981) both incorporated herein by reference. These syntheses may employ an automated synthesizer, as described in Needham-VanDevanter, D. R., et al.,  Nucleic Acids Res . 12:61596168 (1984). Purification of oligonucleotides may be carried out by either native acrylamide gel electrophoresis or by anion-exchange HPLC as described in Pearson, J. D. and Regnier, F. E., ,J. Chrom, 255:137-149 (1983). A double stranded fragment may then be obtained, if desired, by annealing appropriate complementary single strands together under suitable conditions or by synthesizing the complementary strand using a DNA polymerase with an appropriate primer sequence. Where a specific sequence for a nucleic acid probe is given, it is understood that the complementary strand is also identified and included. The complementary strand will work equally well in situations where the target is a double-stranded nucleic acid. 
     The sequence of the synthetic oligonucleotide or of any nucleic acid fragment can be can be obtained using either the dideoxy chain termination method or the Maxam-Gilbert method (see Sambrook et al.  Molecular Cloning—a Laboratory Manual  (2nd Ed.), Vols. 1-3, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., (1989), which is incorporated herein by reference. This manual is hereinafter referred to as “Sambrook et al.”; Zyskind et al., (1988)). Recombinant DNA Laboratory Manual, (Acad. Press, New York). Oligonucleotides useful in diagnostic assays are typically at least 8 consecutive nucleotides in length, and may range upwards of 18 nucleotides in length to greater than 100 or more consecutive nucleotides. 
     Another aspect of the invention pertains to isolated antisense nucleic acid molecules that are hybridizable to or complementary to the nucleic acid molecule comprising the SNP-containing nucleotide sequences of the invention, or fragments, analogs or derivatives thereof. An “antisense” nucleic acid comprises a nucleotide sequence that is complementary to a “sense” nucleic acid encoding a protein, e.g., complementary to the coding strand of a double-stranded cDNA molecule or complementary to an mRNA sequence. In specific aspects, antisense nucleic acid molecules are provided that comprise a sequence complementary to at least about 10, about 25, about 50, or about 60 nucleotides or an entire SNP coding strand, or to only a portion thereof. 
     In one embodiment, an antisense nucleic acid molecule is antisense to a “coding region” of the coding strand of a polymorphic nucleotide sequence of the invention. The term “coding region” refers to the region of the nucleotide sequence comprising codons which are translated into amino acid. In another embodiment, the antisense nucleic acid molecule is antisense to a “noncoding region” of the coding strand of a nucleotide sequence of the invention. The term “noncoding region” refers to 5′ and 3′ sequences which flank the coding region that are not translated into amino acids (i.e., also referred to as 5′ and 3′ untranslated regions). 
     Given the coding strand sequences disclosed herein, antisense nucleic acids of the invention can be designed according to the rules of Watson and Crick or Hoogsteen base pairing. For example, the antisense nucleic acid molecule can generally be complementary to the entire coding region of an mRNA, but more preferably as embodied herein, it is an oligonucleotide that is antisense to only a portion of the coding or noncoding region of the mRNA. An antisense oligonucleotide can range in length between about 5 and about 60 nucleotides, preferably between about 10 and about 45 nucleotides, more preferably between about 15 and 40 nucleotides, and still more preferably between about 15 and 30 in length. An antisense nucleic acid of the invention can be constructed using chemical synthesis or enzymatic ligation reactions using procedures known in the art. For example, an antisense nucleic acid (e.g., an antisense oligonucleotide) can be chemically synthesized using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used. 
     Examples of modified nucleotides that can be used to generate the antisense nucleic acid include: 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5′-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N6-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl) uracil, (acp3)w, and 2,6-diaminopurine. Alternatively, the antisense nucleic acid can be produced biologically using an expression vector into which a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following subsection). 
     The antisense nucleic acid molecules of the invention are typically administered to a subject or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding a polymorphic protein to thereby inhibit expression of the protein, e.g., by inhibiting transcription and/or translation. The hybridization can be by conventional nucleotide complementary to form a stable duplex, or, for example, in the case of an antisense nucleic acid molecule that binds to DNA duplexes, through specific interactions in the major groove of the double helix. An example of a route of administration of anti sense nucleic acid molecules of the invention includes direct injection at a tissue site. Alternatively, antisense nucleic acid molecules can be modified to target selected cells and then administered systemically. For example, for systemic administration, antisense molecules can be modified such that they specifically bind to receptors or antigens expressed on a selected cell surface, e.g., by linking the antisense nucleic acid molecules to peptides or antibodies that bind to cell surface receptors or antigens. The antisense nucleic acid molecules can also be delivered to cells using the vectors described herein. To achieve sufficient intracellular concentrations of antisense molecules, vector constructs in which the antisense nucleic acid molecule is placed under the control of a strong pol II or pol III promoter are preferred. 
     In yet another embodiment, the antisense nucleic acid molecule of the invention is an α-anomeric nucleic acid molecule. An α-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual units, the strands run parallel to each other (Gaultier et al. (1987)  Nucleic Acids Res  15: 6625-6641). The antisense nucleic acid molecule can also comprise a 2′-o-methylribonucleotide (Inoue et al. (1987)  Nucleic Acids Res  15: 6131-6148) or a chimeric RNA -DNA analogue (Inoue et al. (1987)  FEBS Lett  215: 327-330). 
     The following terms are used to describe the sequence relationships between two or more nucleic acids or polynucleotides: “reference sequence”, “comparison window”, “sequence identity”, “percentage of sequence identity”, and “substantial identity”. A “reference sequence” is a defined sequence used as a basis for a sequence comparison; a reference sequence may be a subset of a larger sequence, for example, as a segment of a full-length cDNA or gene sequence given in a sequence listing, or may comprise a complete cDNA or gene sequence. Optimal alignment of sequences for aligning a comparison window may, for example, be conducted by the local homology algorithm of Smith and Waterman  Adv. Appl. Math . 2482 (1981), by the homology alignment algorithm of Needleman and Wunsch  J. Mol. Biol . 48:443 (1970), by the search for similarity method of Pearson and Lipman  Proc. Natl. Acad. Sci. U.S.A . 852444 (1988), or by computerized implementations of these algorithms (for example, GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package Release 7.0, Genetics Computer Group, 575 Science Dr., Madison, Wis.). 
     Techniques for nucleic acid manipulation of the nucleic acid sequences harboring the cSNP&#39;s of the invention, such as subcloning nucleic acid sequences encoding polypeptides into expression vectors, labeling probes, DNA hybridization, and the like, are described generally in Sambrook et al., The phrase “nucleic acid sequence encoding” refers to a nucleic acid which directs the expression of a specific protein, peptide or amino acid sequence. The nucleic acid sequences include both the DNA strand sequence that is transcribed into RNA and the RNA sequence that is translated into protein, peptide or amino acid sequence. The nucleic acid sequences include both the full length nucleic acid sequences disclosed herein as well as non-full length sequences derived from the full length protein. It being further understood that the sequence includes the degenerate codons of the native sequence or sequences which may be introduced to provide codon preference in a specific host cell. Consequently, the principles of probe selection and array design can readily be extended to analyze more complex polymorphisms (see EP 730,663). For example, to characterize a triallelic SNP polymorphism, three groups of probes can be designed tiled on the three polymorphic forms as described above. As a further example, to analyze a diallelic polymorphism involving a deletion of a nucleotide, one can tile a first group of probes based on the undeleted polymorphic form as the reference sequence and a second group of probes based on the deleted form as the reference sequence. 
     For assay of genomic DNA, virtually any biological convenient tissue samples include whole blood, semen, saliva, tears, urine, fecal material, sweat, buccal, skin and hair can be used. Genomic DNA is typically amplified before analysis. Amplification is usually effected by PCR using primers flanking a suitable fragment e.g., of 50-500 nucleotides containing the locus of the polymorphism to be analyzed. Target is usually labeled in the course of amplification. The amplification product can be RNA or DNA, single stranded or double stranded. If double stranded, the amplification product is typically denatured before application to an array. If genomic DNA is analyzed without amplification, it may be desirable to remove RNA from the sample before applying it to the array. Such can be accomplished by digestion with DNase-free RNAase. 
     Detection of Polymorphisms in a Nucleic Acid Sample 
     The SNPs disclosed herein can be used to determine which forms of a characterized polymorphism are present in individuals under analysis. 
     The design and use of allele-specific probes for analyzing polymorphisms is described by e.g., Saiki et al., Nature 324, 163-166 (1986); Dattagupta, EP 235,726, Saiki, WO 89/11548. Allele-specific probes can be designed that hybridize to a segment of target DNA from one individual but do not hybridize to the corresponding segment from another individual due to the presence of different polymorphic forms in the respective segments from the two individuals. Hybridization conditions should be sufficiently stringent that there is a significant difference in hybridization intensity between alleles, and preferably an essentially binary response, whereby a probe hybridizes to only one of the alleles. Some probes are designed to hybridize to a segment of target DNA such that the polymorphic site aligns with a central position (e.g., in a 15-mer at the 7 position; in a 16-mer, at either the 7, 8 or 9 position) of the probe. This design of probe achieves good discrimination in hybridization between different allelic forms. 
     Allele-specific probes are often used in pairs, one member of a pair showing a perfect match to a reference form of a target sequence and the other member showing a perfect match to a variant form. Several pairs of probes can then be immobilized on the same support for simultaneous analysis of multiple polymorphisms within the same target sequence. 
     The polymorphisms can also be identified by hybridization to nucleic acid arrays, some examples of which are described in oublished PCT application WO 95/11995. WO 95/11995 also describes subarrays that are optimized for detection of a variant form of a precharacterized polymorphism. Such a subarray contains probes designed to be complementary to a second reference sequence, which is an allelic variant of the first reference sequence. The second group of probes is designed by the same principles, except that the probes exhibit complementarity to the second reference sequence. The inclusion of a second group (or further groups) can be particularly useful for analyzing short subsequences of the primary reference sequence in which multiple mutations are expected to occur within a short distance commensurate with the length of the probes (e.g., two or more mutations within 9 to 21 bases). 
     An allele-specific primer hybridizes to a site on target DNA overlapping a polymorphism and only primes amplification of an allelic form to which the primer exhibits perfect complementarity. See Gibbs, Nucleic Acid Res. 17 2427-2448 (1989). This primer is used in conjunction with a second primer which hybridizes at a distal site. Amplification proceeds from the two-primers, resulting in a detectable product which indicates the particular allelic form is present. A control is usually performed with a second pair of primers, one of which shows a single base mismatch at the polymorphic site and the other of which exhibits perfect complementarity to a distal site. The single-base mismatch prevents amplification and no detectable product is formed. The method works best when the mismatch is included in the 3′-most position of the oligonucleotide aligned with the polymorphism because this position is most destabilizing to elongation from the primer (see, e.g., WO 93/22456). 
     Amplification products generated using the polymerase chain reaction can be analyzed by the use of denaturing gradient gel electrophoresis. Different alleles can be identified based on the different sequence-dependent melting properties and electrophoretic migration of DNA in solution. Erlich, ed., PCR Technology, Principles and Applications for DNA Amplification, (W. H. Freeman and Co New York, 1992, Chapter 7). 
     Alleles of target sequences can be differentiated using single-strand conformation polymorphism analysis, which identifies base differences by alteration in electrophoretic migration of single stranded PCR products, as described in Orita et al., Proc. Nat. Acad. Sci. 86, 2766-2770 (1989). Amplified PCR products can be generated and heated or otherwise denatured, to form single stranded amplification products. Single-stranded nucleic acids may refold or form secondary structures which are partially dependent on the base sequence. The different electrophoretic mobilities of single-stranded amplification products can be related to base-sequence differences between alleles of target sequences. 
     The genotype of an individual with respect to a pathology suspected of being caused by a genetic polymorphism may be assessed by association analysis. Phenotypic traits suitable for association analysis include diseases that have known but hitherto unmapped genetic components (e.g., agammaglobulinemia, diabetes insipidus, Lesch-Nyhan syndrome, muscular dystrophy, Wiskott-Aldrich syndrome, Fabry&#39;s disease, familial hypercholesterolemia, polycystic kidney disease, hereditary spherocytosis, von Willebrand&#39;s disease, tuberous sclerosis, hereditary hemorrhagic telangiectasia, familial colonic polyposis, Ehlers-Danlos syndrome, osteogenesis imperfecta, and acute intermittent porphyria). 
     Phenotypic traits also include symptoms of, or susceptibility to, multifactorial diseases of which a component is or may be genetic, such as autoimmune diseases, inflammation, cancer, system, diseases of the nervous and infection by pathogenic microorganisms. Some examples of autoimmune diseases include rheumatoid arthritis, multiple sclerosis, diabetes (insulin-dependent and non-independent), systemic lupus erythematosus and Graves disease. Some examples of cancers include cancers of the bladder, brain, breast, colon, esophagus, kidney, oral cavity, ovary, pancreas, prostate, skin, stomach, leukemia, liver, lung, and uterus. Phenotypic traits also include characteristics such as longevity, appearance (e.g., baldness, obesity), strength, speed, endurance, fertility, and susceptibility or receptivity to particular drugs or therapeutic treatments. 
     Such correlations can be exploited in several ways. In the case of a strong correlation between a polymorphic form and a disease for which treatment is available, detection of the polymorphic form set in a human or animal patient may justify immediate administration of treatment, or at least the institution of regular monitoring of the patient. Detection of a polymorphic form correlated with serious disease in a couple contemplating a family may also be valuable to the couple in their reproductive decisions. For example, the female partner might elect to undergo in vitro fertilization to avoid the possibility of transmitting such a polymorphism from her husband to her offspring. In the case of a weaker, but still statistically significant correlation between a polymorphic set and human disease, immediate therapeutic intervention or monitoring may not be justified. Nevertheless, the patient can be motivated to begin simple life-style changes (e.g., diet, exercise) that can be accomplished at little cost to the patient but confer potential benefits in reducing the risk of conditions to which the patient may have increased susceptibility by virtue of variant alleles. After determining polymorphic form(s) present in an individual at one or more polymorphic sites, this information can be used in a number of methods. 
     Determination of which polymorphic forms occupy a set of polymorphic sites in an individual identifies a set of polymorphic forms that distinguishes the individual. See generally National Research Council,  The Evaluation of Forensic DNA Evidence  (Eds. Pollard et al., National Academy Press, DC, 1996). Since the polymorphic sites are within a 50,000 bp region in the human genome, the probability of recombination between these polymorphic sites is low. That low probability means the haplotype (the set of all 10 polymorphic sites) set forth in this application should be inherited without change for at least several generations. The more sites that are analyzed the lower the probability that the set of polymorphic forms in one individual is the same as that in an unrelated individual. Preferably, if multiple sites are analyzed, the sites are unlinked. Thus, polymorphisms of the invention are often used in conjunction with polymorphisms in distal genes. Preferred polymorphisms for use in forensics are diallelic because the population frequencies of two polymorphic forms can usually be determined with greater accuracy than those of multiple polymorphic forms at multi-allelic loci. 
     The capacity to identify a distinguishing or unique set of forensic markers in an individual is useful for forensic analysis. For example, one can determine whether a blood sample from a suspect matches a blood or other tissue sample from a crime scene by determining whether the set of polymorphic forms occupying selected polymorphic sites is the same in the suspect and the sample. If the set of polymorphic markers does not match between a suspect and a sample, it can be concluded (barring experimental error) that the suspect was not the source of the sample. If the set of markers does match, one can conclude that the DNA from the suspect is consistent with that found at the crime scene. If frequencies of the polymorphic forms at the loci tested have been determined (e.g., by analysis of a suitable population of individuals), one can perform a statistical analysis to determine the probability that a match of suspect and crime scene sample would occur by chance. 
     p(ID) is the probability that two random individuals have the same polymorphic or allelic form at a given polymorphic site. In diallelic loci, four genotypes are possible: AA, AB, BA, and BB. If alleles A and B occur in a haploid genome of the organism with frequencies x and y, the probability of each genotype in a diploid organism are (see WO 95/12607): 
     
       
         Homozygote:  p ( AA )= x   2   
       
     
     
       
         Homozygote:  p ( BB )= y   2 =(1 −x ) 2   
       
     
     
       
         Single Heterozygote:  p ( AB )= p ( BA )= xy=x (1 −x ) 
       
     
     
       
         Both Heterozygotes:  p ( AB+BA )=2 xy =2 x (1 −x ) 
       
     
     The probability of identity at one locus (i.e, the probability that two individuals, picked at random from a population will have identical polymorphic forms at a given locus) is given by the equation: 
     
       
           p ( ID )=( x   2 ) 2+ (2 xy ) 2+ ( y   2 ) 2 . 
       
     
     These calculations can be extended for any number of polymorphic forms at a given locus. For example, the probability of identity p(ID) for a 3-allele system where the alleles have the frequencies in the population of x, y and z, respectively, is equal to the sum of the squares of the genotype frequencies: 
     
       
           p ( ID )= x   4+ (2 xy ) 2+ (2 yz ) 2+ (2 xz ) 2+   z   4+   y   4   
       
     
     In a locus of n alleles, the appropriate binomial expansion is used to calculate p(ID) and p(exc). 
     The cumulative probability of identity (cum p(ID)) for each of multiple unlinked loci is determined by multiplying the probabilities provided by each locus: 
     
       
           cum p ( ID )= p ( ID 1) p ( ID 2) p ( ID 3) . . .  p ( IDn ) 
       
     
     The cumulative probability of non-identity for n loci (i.e. the probability that two random individuals will be different at 1 or more loci) is given by the equation: 
     
       
           cum p ( nonID )=1 −cum p ( ID ). 
       
     
     If several polymorphic loci are tested, the cumulative probability of non-identity for random individuals becomes very high (e.g., one billion to one). Such probabilities can be taken into account together with other evidence in determining the guilt or innocence of the suspect. 
     The object of paternity testing is usually to determine whether a male is the father of a child. In most cases, the mother of the child is known and thus, the mother&#39;s contribution to the child&#39;s genotype can be traced. Paternity testing investigates whether the part of the child&#39;s genotype not attributable to the mother is consistent with that of the putative father. Paternity testing can be performed by analyzing sets of polymorphisms in the putative father and the child. 
     If the set of polymorphisms in the child attributable to the father does not match the putative father, it can be concluded, barring experimental error, that the putative father is not the real father. If the set of polymorphisms in the child attributable to the father does match the set of polymorphisms of the putative father, a statistical calculation can be performed to determine the probability of coincidental match. 
     The probability of parentage exclusion (representing the probability that a random male will have a polymorphic form at a given polymorphic site that makes him incompatible as the father) is given by the equation (see WO 95/12607): 
     
       
           p ( exc )= xy (1 −xy ) 
       
     
     where x and y are the population frequencies of alleles A and B of a diallelic polymorphic site. (At a triallelic site p(exc)=xy(1−xy)+yz(1−yz)+xz(1−xz)+3xyz(1−xyz))), where x, y and z and the respective population frequencies of alleles A, B and C). The probability of non-exclusion is: 
     
       
           p ( non - exc )=1 −p ( exc ) 
       
     
     The cumulative probability of non-exclusion (representing the value obtained when n loci are used) is thus: 
     
       
           cum p ( non - exc )= p ( non - exc 1) p ( non - exc 2) p ( non - exc 3) . . .  p ( non - excn ) 
       
     
     The cumulative probability of exclusion for n loci (representing the probability that a random male will be excluded) is: 
     
       
           cum p ( exc )=1 −cum p ( non - exc ). 
       
     
     If several polymorphic loci are included in the analysis, the cumulative probability of exclusion of a random male is very high. This probability can be taken into account in assessing the liability of a putative father whose polymorphic marker set matches the child&#39;s polymorphic marker set attributable to his/her father. 
     The polymorphisms of the invention may contribute to the phenotype of an organism in different ways. Some polymorphisms occur within a protein coding sequence and contribute to phenotype by affecting protein structure. The effect may be neutral, beneficial or detrimental, or both beneficial and detrimental, depending on the circumstances. For example, a heterozygous sickle cell mutation confers resistance to malaria, but a homozygous sickle cell mutation is usually lethal. Other polymorphisms occur in noncoding regions but may exert phenotypic effects indirectly via influence on replication, transcription, and translation. A single polymorphism may affect more than one phenotypic trait. Likewise, a single phenotypic trait may be affected by polymorphisms in different genes. Further, some polymorphisms predispose an individual to a distinct mutation that is causally related to a certain phenotype. 
     Phenotypic traits include diseases that have known but hitherto unmapped genetic components. Phenotypic traits also include symptoms of, or susceptibility to, multifactorial diseases of which a component is or may be genetic, such as autoimmune diseases, inflammation, cancer, diseases of the nervous system, and infection by pathogenic microorganisms. Some examples of autoimmune diseases include rheumatoid arthritis, multiple sclerosis, diabetes (insulin-dependent and non-independent), systemic lupus erythematosus and Graves disease. Some examples of cancers include cancers of the bladder, brain, breast, colon, esophagus, kidney, leukemia, liver, lung, oral cavity, ovary, pancreas, prostate, skin, stomach and uterus. Phenotypic traits also include characteristics such as longevity, appearance (e.g., baldness, obesity), strength, speed, endurance, fertility, and susceptibility or receptivity to particular drugs or therapeutic treatments. 
     Correlation is performed for a population of individuals who have been tested for the presence or absence of a phenotypic trait of interest and for polymorphic markers sets. To perform such analysis, the presence or absence of a set of polymorphisms (i.e. a polymorphic set) is determined for a set of the individuals, some of whom exhibit a particular trait, and some of which exhibit lack of the trait. The alleles of each polymorphism of the set are then reviewed to determine whether the presence or absence of a particular allele is associated with the trait of interest. Correlation can be performed by standard statistical methods such as a κ-squared test and statistically significant correlations between polymorphic form(s) and phenotypic characteristics are noted. For example, it might be found that the presence of allele A1 at polymorphism A correlates with heart disease. As a further example, it might be found that the combined presence of allele A1 at polymorphism A and allele B1 at polymorphism B correlates with increased milk production of a farm animal. 
     Such correlations can be exploited in several ways. In the case of a strong correlation between a set of one or more polymorphic forms and a disease for which treatment is available, detection of the polymorphic form set in a human or animal patient may justify immediate administration of treatment, or at least the institution of regular monitoring of the patient. Detection of a polymorphic form correlated with serious disease in a couple contemplating a family may also be valuable to the couple in their reproductive decisions. For example, the female partner might elect to undergo in vitro fertilization to avoid the possibility of transmitting such a polymorphism from her husband to her offspring. In the case of a weaker, but still statistically significant correlation between a polymorphic set and human disease, immediate therapeutic intervention or monitoring may not be justified. Nevertheless, the patient can be motivated to begin simple life-style changes (e.g., diet, exercise) that can be accomplished at little cost to the patient but confer potential benefits in reducing the risk of conditions to which the patient may have increased susceptibility by virtue of variant alleles. Identification of a polymorphic set in a patient correlated with enhanced receptiveness to one of several treatment regimes for a disease indicates that this treatment regime should be followed. 
     For animals and plants, correlations between characteristics and phenotype are useful for breeding for desired characteristics. For example, Beitz et al., U.S. Pat. No. 5,292,639 discuss use of bovine mitochondrial polymorphisms in a breeding program to improve milk production in cows. To evaluate the effect of mtDNA D-loop sequence polymorphism on milk production, each cow was assigned a value of 1 if variant or 0 if wild type with respect to a prototypical mitochondrial DNA sequence at each of 17 locations considered. 
     The previous section concerns identifying correlations between phenotypic traits and polymorphisms that directly or indirectly contribute to those traits. The present section describes identification of a physical linkage between a genetic locus associated with a trait of interest and polymorphic markers that are not associated with the trait, but are in physical proximity with the genetic locus responsible for the trait and co-segregate with it. Such analysis is useful for mapping a genetic locus associated with a phenotypic trait to a chromosomal position, and thereby cloning gene(s) responsible for the trait. See Lander et al.,  Proc. Natl. Acad. Sci . ( USA ) 83, 7353-7357 (1986); Lander et al.,  Proc. Natl. Acad. Sci . ( USA ) 84, 2363-2367 (1987); Donis-Keller et al.,  Cell  51, 319-337 (1987); Lander et al.,  Genetics  121, 185-199 (1989)). Genes localized by linkage can be cloned by a process known as directional cloning. See Wainwright,  Med. J. Australia  159, 170-174 (1993); Collins,  Nature Genetics  1, 3-6 (1992) (each of which is incorporated by reference in its entirety for all purposes). 
     Linkage studies are typically performed on members of a family. Available members of the family are characterized for the presence or absence of a phenotypic trait and for a set of polymorphic markers. The distribution of polymorphic markers in an informative meiosis is then analyzed to determine which polymorphic markers co-segregate with a phenotypic trait. See, e.g., Kerem et al.,  Science  245, 1073-1080 (1989); Monaco et al.,  Nature  316, 842 (1985); Yamoka et al.,  Neurology  40, 222-226 (1990); Rossiter et al.,  FASEB Journal  5, 21-27 (1991). 
     Linkage is analyzed by calculation of LOD (log of the odds) values. A lod value is the relative likelihood of obtaining observed segregation data for a marker and a genetic locus when the two are located at a recombination fraction , versus the situation in which the two are not linked, and thus segregating independently (Thompson &amp; Thompson,  Genetics in Medicine  (5th ed, W. B. Saunders Company, Philadelphia, 1991); Strachan, “Mapping the human genome” in  The Human Genome  (BIOS Scientific Publishers Ltd, Oxford), Chapter 4). A series of likelihood ratios are calculated at various recombination fractions (), ranging from =0.0 (coincident loci) to =0.50 (unlinked). Thus, the likelihood at a given value of  is: probability of data if loci linked at  to probability of data if loci unlinked. The computed likelihood is usually expressed as the log 10  of this ratio (i.e., a lod score). For example, a lod score of 3 indicates 1000:1 odds against an apparent observed linkage being a coincidence. The use of logarithms allows data collected from different families to be combined by simple addition. Computer programs are available for the calculation of lod scores for differing values of  (e.g., LIPED, MLINK (Lathrop,  Proc. Nat. Acad Sci . (USA) 81, 3443-3446 (1984)). For any particular lod score, a recombination fraction may be determined from mathematical tables. See Smith et al.,  Mathematical tables for research workers in human genetics  (Churchill, London, 1961); Smith,  Ann. Hum. Genet.  32, 127-150 (1968). The value of  at which the lod score is the highest is considered to be the best estimate of the recombination fraction. 
     Positive lod score values suggest that the two loci are linked, whereas negative values suggest that linkage is less likely (at that value of ) than the possibility that the two loci are unlinked. By convention, a combined lod score of +3 or greater (equivalent to greater than 1000:1 odds in favor of linkage) is considered definitive evidence that two loci are linked. Similarly, by convention, a negative lod score of −2 or less is taken as definitive evidence against linkage of the two loci being compared. Negative linkage data are useful in excluding a chromosome or a segment thereof from consideration. The search focuses on the remaining non-excluded chromosomal locations. 
     The invention further provides transgenic nonhuman animals capable of expressing an exogenous variant gene and/or having one or both alleles of an endogenous variant gene inactivated. Expression of an exogenous variant gene is usually achieved by operably linking the gene to a promoter and optionally an enhancer, and microinjecting the construct into a zygote. See Hogan et al., “Manipulating the Mouse Embryo, A Laboratory Manual,” Cold Spring Harbor Laboratory. (1989). Inactivation of endogenous variant genes can be achieved by forming a transgene in which a cloned variant gene is inactivated by insertion of a positive selection marker. See Capecchi, Science 244, 1288-1292 The transgene is then introduced into an embryonic stem cell, where it undergoes homologous recombination with an endogenous variant gene. Mice and other rodents are preferred animals. Such animals provide useful drug screening systems. 
     The invention further provides methods for assessing the pharmacogenomic susceptibility of a subject harboring a single nucleotide polymorphism to a particular pharmaceutical compound, or to a class of such compounds. Genetic polymorphism in drug-metabolizing enzymes, drug transporters, receptors for pharmaceutical agents, and other drug targets have been correlated with individual differences based on distinction in the efficacy and toxicity of the pharmaceutical agent administered to a subject. Pharmocogenomic characterization of a subjects susceptibility to a drug enhances the ability to tailor a dosing regimen to the particular genetic constitution of the subject, thereby enhancing and optimizing the therapeutic effectiveness of the therapy. 
     In cases in which a cSNP leads to a polymorphic protein that is ascribed to be the cause of a pathological condition, method of treating such a condition includes administering to a subject experiencing the pathology the wild type cognate of the polymorphic protein. Once administered in an effective dosing regimen, the wild type cognate provides complementation or remediation of the defect due to the polymorphic protein. The subject&#39;s condition is ameliorated by this protein therapy. 
     A subject suspected of suffering from a pathology ascribable to a polymorphic protein that arises from a cSNP is to be diagnosed using any of a variety of diagnostic methods capable of identifying the presence of the cSNP in the nucleic acid, or of the cognate polymorphic protein, in a suitable clinical sample taken from the subject. Once the presence of the cSNP has been ascertained, and the pathology is correctable by administering a normal or wild-type gene, the subject is treated with a pharmaceutical composition that includes a nucleic acid that harbors the correcting wild-type gene, or a fragment containing a correcting sequence of the wild-type gene. Non-limiting examples of ways in which such a nucleic acid may be administered include incorporating the wild-type gene in a viral vector, such as an adenovirus or adeno associated virus, and administration of a naked DNA in a pharmaceutical composition that promotes intracellular uptake of the administered nucleic acid. Once the nucleic acid that includes the gene coding for the wild-type allele of the polymorphism is incorporated within a cell of the subject, it will initiate de novo biosynthesis of the wild-type gene product. If the nucleic acid is further incorporated into the genome of the subject, the treatment will have long-term effects, providing de novo synthesis of the wild-type protein for a prolonged duration. The synthesis of the wild-type protein in the cells of the subject will contribute to a therapeutic enhancement of the clinical condition of the subject. 
     A subject suffering from a pathology ascribed to a SNP may be treated so as to correct the genetic defect. (See Kren et al., Proc. Natl. Acad. Sci. USA 96:10349-10354 (1999)). Such a subject is identified by any method that can detect the polymorphism in a sample drawn from the subject. Such a genetic defect may be permanently corrected by administering to such a subject a nucleic acid fragment incorporating a repair sequence that supplies the wild-type nucleotide at the position of the SNP. This site-specific repair sequence encompasses an RNA/DNA oligonucleotide which operates to promote endogenous repair of a subject&#39;s genomic DNA. Upon administration in an appropriate vehicle, such as a complex with polyethylenimine or encapsulated in anionic liposomes, a genetic defect leading to an inborn pathology may be overcome, as the chimeric oligonucleotides induces incorporation of the wild-type sequence into the subject&#39;s genome. Upon incorporation, the wild-type gene product is expressed, and the replacement is propagated, thereby engendering a permanent repair. 
     The invention further provides kits comprising at least one allele-specific oligonucleotide as described above. Often, the kits contain one or more pairs of allele-specific oligonucleotides hybridizing to different forms of a polymorphism. In some kits, the allele-specific oligonucleotides are provided immobilized to a substrate. For example, the same substrate can comprise allele-specific oligonucleotide probes for detecting at least 10, 100, 1000 or all of the polymorphisms shown in the Table. Optional additional components of the kit include, for example, restriction enzymes, reverse-transcriptase or polymerase, the substrate nucleoside triphosphates, means used to label (for example, an avidin-enzyme conjugate and enzyme substrate and chromogen if the label is biotin), and the appropriate buffers for reverse transcription, PCR, or hybridization reactions. Usually, the kit also contains instructions for carrying out the hybridizing methods. 
     Several aspects of the present invention rely on having available the polymorphic proteins encoded by the nucleic acids comprising a SNP of the inventions. There are various methods of isolating these nucleic acid sequences. For example, DNA is isolated from a genomic or cDNA library using labeled oligonucleotide probes having sequences complementary to the sequences disclosed herein. 
     Such probes can be used directly in hybridization assays. Alternatively probes can be designed for use in amplification techniques such as PCR. 
     To prepare a cDNA library, mRNA is isolated from tissue such as heart or pancreas, preferably a tissue wherein expression of the gene or gene family is likely to occur. cDNA is prepared from the mRNA and ligated into a recombinant vector. The vector is transfected into a recombinant host for propagation, screening and cloning. Methods for making and screening cDNA libraries are well known, See Gubler, U. and Hoffman, B. J. Gene 25:263-269 (1983) and Sambrook et al. 
     For a genomic library, for example, the DNA is extracted from tissue and either mechanically sheared or enzymatically digested to yield fragments of about 12-20 kb. The fragments are then separated by gradient centrifugation from undesired sizes and are constructed in bacteriophage lambda vectors. These vectors and phage are packaged in vitro, as described in Sambrook, et al. Recombinant phage are analyzed by plaque hybridization as described in Benton and Davis,  Science  196:180-182 (1977). Colony hybridization is carried out as generally described in M. Grunstein et al. Proc. Natl. Acad. Sci. USA. 72:3961-3965 (1975). DNA of interest is identified in either cDNA or genomic libraries by its ability to hybridize with nucleic acid probes, for example on Southern blots, and these DNA regions are isolated by standard methods familiar to those of skill in the art. See Sambrook, et al. 
     In PCR techniques, oligonucleotide primers complementary to the two 3′ borders of the DNA region to be amplified are synthesized. The polymerase chain reaction is then carried out using the two primers. See PCR Protocols: a Guide to Methods and Applications (Innis, M, Gelfand, D., Sninsky, J. and White, T., eds.), Academic Press, San Diego (1990). Primers can be selected to amplify the entire regions encoding a full-length sequence of interest or to amplify smaller DNA. segments as desired. PCR can be used in a variety of protocols to isolate cDNA&#39;s encoding a sequence of interest. In these protocols, appropriate primers and probes for amplifying DNA encoding a sequence of interest are generated from analysis of the DNA sequences listed herein. Once such regions are PCR-amplified, they can be sequenced and oligonucleotide probes can be prepared from the sequence. 
     Once DNA encoding a sequence comprising a cSNP is isolated and cloned, one can express the encoded polymorphic proteins in a variety of recombinantly engineered cells. It is expected that those of skill in the art are knowledgeable in the numerous expression systems available for expression of DNA encoding a sequence of interest. No attempt to describe in detail the various methods known for the expression of proteins in prokaryotes or eukaryotes is made here. 
     In brief summary, the expression of natural or synthetic nucleic acids encoding a sequence of interest will typically be achieved by operably linking the DNA or cDNA to a promoter (which is either constitutive or inducible), followed by incorporation into an expression vector. The vectors can be suitable for replication and integration in either prokaryotes or eukaryotes. Typical expression vectors contain, initiation sequences, transcription and translation terminators, and promoters useful for regulation of the expression of a polynucleotide sequence of interest. To obtain high level expression of a cloned gene, it is desirable to construct expression plasmids which contain, at the minimum, a strong promoter to direct transcription, a ribosome binding site for translational initiation, and a transcription/translation terminator. The expression vectors may also comprise generic expression cassettes containing at least one independent terminator sequence, sequences permitting replication of the plasmid in both eukaryotes and prokaryotes, i.e., shuttle vectors, and selection markers for both prokaryotic and eukaryotic systems. See Sambrook et al. 
     A variety of prokaryotic expression systems may be used to express the polymorphic proteins of the invention. Examples include  E. coli , Bacillus, Streptomyces, and the like. 
     It is preferred to construct expression plasmids which contain, at the minimum, a strong promoter to direct transcription, a ribosome binding site for translational initiation, and a transcription/translation terminator. Examples of regulatory regions suitable for this purpose in  E. coli  are the promoter and operator region of the  E. coli  tryptophan biosynthetic pathway as described by Yanofsky, C., J. Bacterial. 158:1018-1024 (1984) and the leftward promoter of phage lambda (P) as described by A, I. and Hagen, D.,  Ann. Rev. Genet . 14:399-445 (1980). The inclusion of selection markers in DNA vectors transformed in  E. coli  is also useful. Examples of such markers include genes specifying resistance to ampicillin, tetracycline, or chloramphenicol. See Sambrook et al. for details concerning selection markers for use in  E. coli.    
     To enhance proper folding of the expressed recombinant protein, during purification from  E. coli , the expressed protein may first be denatured and then renatured. This can be accomplished by solubilizing the bacterially produced proteins in a chaotropic agent such as guanidine HCI and reducing all the cysteine residues with a reducing agent such as beta-mercaptoethanol. The protein is then renatured, either by slow dialysis or by gel filtration. See U.S. Pat. No. 4,511,503. Detection of the expressed antigen is achieved by methods known in the art as radioimmunoassay, or Western blotting techniques or immunoprecipitation. Purification from  E. coli  can be achieved following procedures such as those described in U.S. Pat. No. 4,511,503. 
     Any of a variety of eukaryotic expression systems such as yeast, insect cell lines, bird, fish, and mammalian cells, may also be used to express a polymorphic protein of the invention. As explained briefly below, a nucleotide sequence harboring a cSNP may be expressed in these eukaryotic systems. Synthesis of heterologous proteins in yeast is well known.  Methods in Yeast Genetics , Sherman, F., et al., Cold Spring Harbor Laboratory, (1982) is a well recognized work describing the various methods available to produce the protein in yeast. Suitable vectors usually have expression control sequences, such as promoters, including 3-phosphogtycerate kinase or other glycolytic enzymes, and an origin of replication, termination sequences and the like as desired. For instance, suitable vectors are described in the literature (Botstein, et al., Gene 8:17-24 (1979); Broach, et al., Gene 8:121-133 (1979)). 
     Two procedures are used in transforming yeast cells. In one case, yeast cells are first converted into protoplasts using zymolyase, lyticase or glusulase, followed by addition of DNA and polyethylene glycol (PEG). The PEG-treated protoplasts are then regenerated in a 3% agar medium under selective conditions. Details of this procedure are given in the papers by J. D. Beggs, Nature (London) 275:104-109 (1978); and Hinnen, A., et al., Proc. Natl. Acad. Sci. USA, 75:1929-1933 (1978). The second procedure does not involve removal of the cell wall. Instead the cells are treated with lithium chloride or acetate and PEG and put on selective plates (Ito, H., et al., J. Bact, 153163-168 (1983)). cells and applying standard protein isolation techniques to the lysates:. 
     The purification process can be monitored by using Western blot techniques or radioimmunoassay or other standard techniques. The sequences encoding the proteins of the invention can also be ligated to various immunoassay expression vectors for use in transforming cell cultures of, for instance, mammalian, insect, bird or fish origin. Illustrative of cell cultures useful for the production of the polypeptides are mammalian cells. Mammalian cell systems often will be in the form of monolayers of cells although mammalian cell suspensions may also be used. A number of suitable host cell lines capable of expressing intact proteins have been developed in the art, and include the HEK293, BHK21, and CHO cell lines, and various human cells such as COS cell lines, HeLa cells, myeloma cell lines, Jurkat cells, etc. Expression vectors for these cells can include expression control sequences, such as an origin of replication, a promoter (e.g., the CMV promoter, a HSV tk promoter or pgk (phosphoglycerate kinase) promoter), an enhancer (Queen et al.  Immunol. Rev , 89:49 (1986)) and necessary processing information sites, such as ribosome binding sites, RNA splice sites, polyadenylation sites (e.g., an SV40 large T Ag poly A addition site), and transcriptional terminator sequences. 
     Other animal cells are available, for instance, from the American Type Culture Collection Catalogue of Cell Lines and Hybridomas (7th edition, (1992)). Appropriate vectors for expressing the proteins of the invention in insect cells are usually derived from baculovirus. Insect cell lines include mosquito larvae, silkworm, armyworm, moth and Drosophila cell lines such as a Schneider cell line (See Schneider J. Embryol. Exp. Morphol., 27:353-365 (1987). As indicated above, the vector, e.g., a plasmid, which is used to transform the host cell, preferably contains DNA sequences to initiate transcription and sequences to control the translation of the protein. These sequences are referred to as expression control sequences. As with yeast, when higher animal host cells are employed, polyadenylation or transcription terminator sequences from known mammalian genes need to be incorporated into the vector. An example of a terminator sequence is the polyadenylation sequence from the bovine growth hormone gene. Sequences for accurate splicing of the transcript may also be included. An example of a splicing sequence is the VP1 intron from SV40 (Sprague, J. et a/., J. Virol. 45: 773-781 (1983)). Additionally, gene sequences to control replication in the host cell may be Saveria-Campo, M., 1985, “Bovine Papilloma virus DNA a Eukaryotic Cloning Vector” in DNA Cloning Vol. II a Practical Approach Ed. D. M. Glover, IRL Press, Arlington, Va. pp. 213-238. The host cells are competent or rendered competent for transformation by various means. There are several well-known methods of introducing DNA into animal cells. These include: calcium phosphate precipitation, fusion of the recipient cells with bacterial protoplasts containing the DNA, treatment of the recipient cells with liposomes containing the DNA, DEAE dextran, electroporation and micro-injection of the DNA directly into the cells. 
     The transformed cells are cultured by means well known in the art (Biochemical Methods in Cell Culture and Virology, Kuchler, R. J., Dowden, Hutchinson and Ross, Inc., (1977)). The expressed polypeptides are isolated from cells grown as suspensions or as monolayers. The latter are recovered by well known mechanical, chemical or enzymatic means. 
     General methods of expressing recombinant proteins are also known and are exemplified in R. Kaufman, Methods in Enzymology 185, 537-566 (1990). As defined herein “operably linked” refers to linkage of a promoter upstream from a DNA sequence such that the promoter mediates transcription of the DNA sequence. Specifically, “operably linked” means that the isolated polynucleotide of the invention and an expression control sequence are situated within a vector or cell in such a way that the gene encoding the protein is expressed by a host cell which has been transformed (transfected) with the ligated polynucleotide/expression sequence. The term “vector”, refers to viral expression systems, autonomous self-replicating circular DNA (plasmids), and includes both expression and nonexpression plasmids. 
     The term “gene” as used herein is intended to refer to a nucleic acid sequence which encodes a polypeptide. This definition includes various sequence polymorphisms, mutations, and/or sequence variants wherein such alterations do not affect the function of the gene product. The term “gene” is intended to include not only coding sequences but also regulatory regions such as promoters, enhancers, termination regions and similar untranslated nucleotide sequences. The term further includes all introns and other DNA sequences spliced from the mRNA transcript, along with variants resulting from alternative splice sites. 
     A number of types of cells may act as suitable host cells for expression of the protein. Mammalian host cells include, for example, monkey COS cells, Chinese Hamster Ovary (CHO) cells, human kidney 293 cells, human epidermal A43 1 cells, human Co10205 cells, 3T3 cells, CV-1 cells, other transformed primate cell lines, normal diploid cells, cell strains derived from in vitro culture of primary tissue, primary explants, HeLa cells, mouse L cells, BHK, HL-60, U937, HaK or Jurkat cells. Alternatively, it may be possible to produce the protein in lower eukaryotes such as yeast or in prokaryotes such as bacteria. Potentially suitable yeast strains include  Saccharomyces cerevisiae, Schizosaccharomyces pombe , Kluyveromyces strains, Candida or any yeast strain capable of expressing heterologous proteins. Potentially suitable bacterial strains include  Escherichia coli, Bacillus subtilis, Salmonella typhimurium , or any bacterial strain capable of expressing heterologous proteins. If the protein is made in yeast or bacteria, it may be necessary to modify the protein produced therein, for example by phosphorylation or glycosylation of the appropriate sites, in order to obtain the functional protein. 
     The protein may also be produced by operably linking the isolated polynucleotide of the invention to suitable control sequences in one or more insect expression vectors, and employing an insect expression system. Materials and methods for baculovirus/insect cell expression systems are commercially available in kit form from, e.g., Invitrogen, San Diego, Calif., U.S.A. (the MaxBac© kit), and such methods are well known in the art, as described in Summers and Smith, Texas Agricultural Experiment Station Bulletin No. 1555 (1987), incorporated herein by reference. As used herein, an insect cell capable of expressing a polynucleotide of the present invention is “transformed.” The protein of the invention may be prepared by culturing transformed host cells under culture conditions suitable to express the recombinant protein. 
     The polymorphic protein of the invention may also be expressed as a product of transgenic animals, e.g., as a component of the milk of transgenic cows, goats, pigs, or sheep which are characterized by somatic or germ cells containing a nucleotide sequence encoding the protein. The protein may also be produced by known conventional chemical synthesis. Methods for constructing the proteins of the present invention by synthetic means are known to those skilled in the art. 
     The polymorphic proteins produced by recombinant DNA technology may be purified by techniques commonly employed to isolate or purify recombinant proteins. Recombinantly produced proteins can be directly expressed or expressed as a fusion protein. The protein is then purified by a combination of cell lysis (e.g., sonication) and affinity chromatography. For fusion products, subsequent digestion of the fusion protein with an appropriate proteolytic enzyme releases the desired polypeptide. The polypeptides of this invention may be purified to substantial purity by standard techniques well known in the art, including selective precipitation with such substances as ammonium sulfate, column chromatography, immunopurification methods, and others. See, for instance, R. Scopes, Protein Purification: Principles and Practice, Springer-Verlag: New York (1982), incorporated herein by reference. For example, in an embodiment, antibodies may be raised to the proteins of the invention as described herein. Cell membranes are isolated from a cell line expressing the recombinant protein, the protein is extracted from the membranes and immunoprecipitated. The proteins may then be further purified by standard protein chemistry techniques as described above. 
     The resulting expressed protein may then be purified from such culture (i.e., from culture medium or cell extracts) using known purification processes, such as gel filtration and ion exchange chromatography. The purification of the protein may also include an affinity column containing agents which will bind to the protein; one or more column steps over such affinity resins as concanavalin A-agarose, heparin-Toyopearl@ or Cibacrom blue 3GA Sepharose B; one or more steps involving hydrophobic interaction chromatography using such resins as phenyl ether, butyl ether, or propyl ether; or immunoaffinity chromatography. Alternatively, the protein of the invention may also be expressed in a form which will facilitate purification. For example, it may be expressed as a fusion protein, such as those of maltose binding protein (MBP), glutathione-S-transferase (GST) or thioredoxin (TRX). Kits for expression and purification of such fusion proteins are commercially available from New England BioLab (Beverly, Mass.), Pharmacia (Piscataway, N.J.) and In Vitrogen, respectively. The protein can also be tagged with an epitope and subsequently purified by using a specific antibody directed to such epitope. One such epitope (“Flag”) is commercially available from Kodak (New Haven, Conn.). Finally, one or more reverse-phase high performance liquid chromatography (RP-HPLC) steps employing hydrophobic RP-HPLC media, e.g., silica gel having pendant methyl or other aliphatic groups, can be employed to further purify the protein. Some or all of the foregoing purification steps, in various combinations, can also be employed to provide a substantially homogeneous isolated recombinant protein. The protein thus purified is substantially free of other mammalian proteins and is defined in accordance with the present invention as an “isolated protein.” 
     The term “antibody” as used herein refers to immunoglobulin molecules and immunologically active portions of immunoglobulin molecules, i.e., molecules that contain an antigen binding site that specifically binds (immunoreacts with) an antigen, such as polymorphic. Such antibodies include, but are not limited to, polyclonal, monoclonal, chimeric, single chain, F ab  and F (ab′)2  fragments, and an F ab  expression library. In a specific embodiment, antibodies to human polymorphic proteins are disclosed. 
     The phrase “specifically binds to”, “immunospecifically binds to” or is “specifically immunoreactive with”, an antibody when referring to a protein or peptide, refers to a binding reaction which is determinative of the presence of the protein in the presence of a heterogeneous population of proteins and other biological materials. Thus, for example, under designated immunoassay conditions, the specified antibodies bind to a particular protein and do not bind in a significant amount to other proteins present in the sample. Specific binding to an antibody under such conditions may require an antibody that is selected for its specificity for a particular protein. Of particular interest in the present invention is an antibody that binds immunospecifically to a polymorphic protein but not to its cognate wild type allelic protein, or vice versa. A variety of immunoassay formats may be used to select antibodies specifically immunoreactive with a particular protein. For example, solid-phase ELISA immunoassays are routinely used to select monoclonal antibodies specifically immunoreactive with a protein. See Harlow and Lane (1988) Antibodies, a Laboratory Manual, Cold Spring Harbor Publications, New York, for a description of immunoassay formats and conditions that can be used to determine specific immunoreactivity. 
     Polyclonal and/or monoclonal antibodies that immunospecifically bind to polymorphic gene products but not to the corresponding prototypical or “wild-type” gene products are also provided. Antibodies can be made by injecting mice or other animals with the variant gene product or synthetic peptide. Monoclonal antibodies are screened as are described, for example, in Harlow &amp; Lane, Antibodies, A Laboratory Manual, Cold Spring Harbor Press, New York (1988); Goding, Monoclonal antibodies, Principles and Practice (2d ed.) Academic Press, New York (1986). Monoclonal antibodies are tested for specific immunoreactivity with a variant gene product and lack of immunoreactivity to the corresponding prototypical gene product. 
     An isolated polymorphic protein, or a portion or fragment thereof, can be used as an immunogen to generate the antibody that bind the polymorphic protein using standard techniques for polyclonal and monoclonal antibody preparation. The full-length polymorphic protein can be used or, alternatively, the invention provides antigenic peptide fragments of polymorphic for use as immunogens. The antigenic peptide of a polymorphic protein of the invention comprises at least 8 amino acid residues of the amino acid sequence encompassing the polymorphic amino acid and encompasses an epitope of the polymorphic protein such that an antibody raised against the peptide forms a specific immune complex with the polymorphic protein. Preferably, the antigenic peptide comprises at least 10 amino acid residues, more preferably at least 15 amino acid residues, even more preferably at least 20 amino acid residues, and most preferably at least 30 amino acid residues. Preferred epitopes encompassed by the antigenic peptide are regions of polymorphic that are located on the surface of the protein, e.g., hydrophilic regions. 
     For the production of polyclonal antibodies, various suitable host animals (e.g., rabbit, goat, mouse or other mammal) may be immunized by injection with the polymorphic protein. An appropriate immunogenic preparation can contain, for example, recombinantly expressed polymorphic protein or a chemically synthesized polymorphic polypeptide. The preparation can further include an adjuvant. Various adjuvants used to increase the immunological response include, but are not limited to, Freund&#39;s (complete and incomplete), mineral gels (e.g., aluminum hydroxide), surface active substances (e.g, lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, dinitrophenol, etc.), human adjuvants such as Bacille Calmette-Guerin and  Corynebacterium parvum , or similar immunostimulatory agents. If desired, the antibody molecules directed against polymorphic proteins can be isolated from the mammal (e.g., from the blood) and further purified by well known techniques, such as protein A chromatography, to obtain the IgG fraction. 
     The term “monoclonal antibody” or “monoclonal antibody composition”, as used herein, refers to a population of antibody molecules that originates from the clone of a singly hybridoma cell, and that contains only one type of antigen binding site capable of immunoreacting with a particular epitope of a polymorphic protein. A monoclonal antibody composition thus typically displays a single binding affinity for a particular polymorphic protein with which it immunoreacts. For preparation of monoclonal antibodies directed towards a particular polymorphic protein, or derivatives, fragments, analogs or homologs thereof, any technique that provides for the production of antibody molecules by continuous cell line culture may be utilized. Such techniques include, but are not limited to, the hybridoma technique (see Kohler &amp; Milstein, 1975  Nature  256: 495-497); the trioma technique; the human B-cell hybridoma technique (see Kozbor, et al., 1983  Immunol Today  4: 72) and the EBV hybridoma technique to produce human monoclonal antibodies (see Cole, et al., 1985 In: Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, Inc., pp. 77-96). Human monoclonal antibodies may be utilized in the practice of the present invention and may be produced by using human hybridomas (see Cote, et al., 1983 . Proc Natl Acad Sci USA  80: 2026-2030) or by transforming human B-cells with Epstein Barr Virus in vitro (see Cole, et al., 1985 In: Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, Inc., pp. 77-96). 
     According to the invention, techniques can be adapted for the production of single-chain antibodies specific to a polymorphic protein (see e.g., U.S. Pat. No. 4,946,778). In addition, methodologies can be adapted for the construction of F ab  expression libraries (see e.g., Huse, et al., 1989  Science  246: 1275-1281) to allow rapid and effective identification of monoclonal F ab  fragments with the desired specificity for a polymorphic protein or derivatives, fragments, analogs or homologs thereof. Non-human antibodies can be “humanized” by techniques well known in the art. See e.g., U.S. Pat. No. 5,225,539. Antibody fragments that contain the idiotypes to a polymorphic protein may be produced by techniques known in the art including, but not limited to: (i) an F (ab′)2  fragment produced by pepsin digestion of an antibody molecule; (ii) an F ab  fragment generated by reducing the disulfide bridges of an F (ab′)2  fragment; (iii) an F ab  fragment generated by the treatment of the antibody molecule with papain and a reducing agent and (iv) F v  fragments. 
     Additionally, recombinant anti-polymorphic protein antibodies, such as chimeric and humanized monoclonal antibodies, comprising both human and non-human portions, which can be made using standard recombinant DNA techniques, are within the scope of the invention. Such chimeric and humanized monoclonal antibodies can be produced by recombinant DNA techniques known in the art, for example using methods described in PCT International Application No. PCT/US86/02269; European Patent Application No. 184,187; European Patent Application No. 171,496; European Patent Application No. 173,494; PCT International Publication No. WO 86/01533; U.S. Pat. No. 4,816,567; European Patent Application No. 125,023; Better et al. (1988)  Science  240:1041-1043; Liu et al. (1987)  PNAS  84:3439-3443; Liu et al. (1987)  J Immunol . 139:3521-3526; Sun et al. (1987)  PNAS  84:214-218; Nishimura et al. (1987)  Cancer Res  47:999-1005; Wood et al. (1985)  Nature  314:446-449; Shaw et al. (1988)  J Natl Cancer Inst  80:1553-1559); Morrison(1985)  Science  229:1202-1207; Oi et al. (1986)  Bio Techniques  4:214; U.S. Pat. No. 5,225,539; Jones et al. (1986)  Nature  321:552-525; Verhoeyan et al. (1988)  Science  239:1534; and Beidler et al. (1988)  J Immunol  141:4053-4060. 
     In one embodiment, methodologies for the screening of antibodies that possess the desired specificity include, but are not limited to, enzyme-linked immunosorbent assay (ELISA) and other immunologically-mediated techniques known within the art. 
     Anti-polymorphic protein antibodies may be used in methods known within the art relating to the detection, quantitation and/or cellular or tissue localization of a polymorphic protein (e.g., for use in measuring levels of the polymorphic protein within appropriate physiological samples, for use in diagnostic methods, for use in imaging the protein, and the like). In a given embodiment, antibodies for polymorphic proteins, or derivatives, fragments, analogs or homologs thereof, that contain the antibody-derived CDR, are utilized as pharmacologically-active compounds in therapeutic applications intended to treat a pathology in a subject that arises from the presence of the cSNP allele in the subject. 
     An anti-polymorphic protein antibody (e.g., monoclonal antibody) can be used to isolate polymorphic proteins by a variety of immunochemical techniques, such as immunoaffinity chromatography or immunoprecipitation. An anti-polymorphic protein antibody can facilitate the purification of natural polymorphic protein from cells and of recombinantly produced polymorphic proteins expressed in host cells. Moreover, an anti-polymorphic protein antibody can be used to detect polymorphic protein (e.g., in a cellular lysate or cell supernatant) in order to evaluate the abundance and pattern of expression of the polymorphic protein. Anti-polymorphic antibodies can be used diagnostically to monitor protein levels in tissue as part of a clinical testing procedure, e.g., to, for example, determine the efficacy of a given treatment regimen. Detection can be facilitated by coupling (i.e., physically linking) the antibody to a detectable substance. Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, -galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials includes umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include  125 I,  131 I,  35 S or  3 H. 
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1 
               
               
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 Protein 
                   
                 Similarity (pValue) 
                   
               
               
                   
                 CuraGen 
                 Base pos. 
                 Polymorphic 
                 Base 
                 base 
                 Amino acid 
                 Amino acid 
                   
                 classification of 
                 Name of protein identified following a 
                 following a 
                 Map 
               
               
                 Seq ID 
                 sequence ID 
                 of SNP 
                 sequence 
                 before 
                 after 
                 before 
                 after 
                 Type of change 
                 BLASTX analysis of the CuraGen sequence 
                 BLASTX analysis 
                 location 
               
               
                   
               
             
            
               
                 1-2 
                 cg34158766 
                  254 
                 TCGGGCTCGT 
                 G 
                 A 
                   
                   
                 SILENT- 
                 angiopoietin 
                 Human Gene Similar to SPTREMBL-ID: O08538 
                 6.00E−34 
                  4 
               
               
                   
                   
                   
                 CCAGCCAAAG 
                   
                   
                 NONCODING 
                   
                 ANGIOPOIETIN-1 -  MUS MUSCULUS  (MOUSE), 
               
               
                   
                   
                   
                 CAGCT[G/A]CC 
                   
                   
                   
                   
                 498 aa. 
               
               
                   
                   
                   
                 ACTCAAAAGAA 
               
               
                   
                   
                   
                 AGTAGAAAGAA 
               
               
                   
                   
                   
                 A 
               
               
                 3-4 
                 cg43299481 
                  218 
                 GTCCCGGTCA 
                 G 
                 gap 
                 SILENT- 
                 dehydrogenase 
                 Human Gene Similar to SPTREMBL-ID: Q44020 
                 9.30E−33 
               
               
                   
                   
                   
                 GGGTGGGCTG 
                   
                   
                 NONCODING 
                   
                 4-HYDROXYBUTYRATE DEHYDROGENASE 
               
               
                   
                   
                   
                 CGGGA[G/gap]C 
                   
                   
                   
                 (GBD), ORF 2 AND 4-10 GENES, COMPLETE 
               
               
                   
                   
                   
                 CTCAGGCCAC 
                   
                   
                 CDS, AND ORF3 AND 11, 3′ END - 
               
               
                   
                   
                   
                 GGGGAAGTAG 
                   
                   
                   ALCALIGENES EUTROPHUS , 173 aa. 
               
               
                   
                   
                   
                 TGGG 
               
               
                 5-6 
                 cg43933536 
                 1628 
                 ACACCGGGGG 
                 C 
                 T 
                 SILENT- 
                 eph 
                 Human Gene Similar to TREMBLNEW-ID: 
                 7.70E−37 
                  3 
               
               
                   
                   
                   
                 GGCGCGGGGG 
                   
                   
                 NONCODING 
                   
                 G2735762 HEAT SHOCK PROTEIN DNAJ - 
               
               
                   
                   
                   
                 TCTCC[C/T]TGG 
                   
                   
                   
                   
                 
                   LEPTOSPIRA INTERROGANS, 369 aa. 
                 
               
               
                   
                   
                   
                 TCCGCAGAGA 
               
               
                   
                   
                   
                 CAGCTAGCTAG 
               
               
                   
                   
                   
                 C 
               
               
                 7-8 
                 cg44021557 
                  391 
                 TGATATCCAGG 
                 T 
                 C 
                 Leu 
                 Leu 
                 SILENT- 
                 helicase 
                 Human Gene Similar to SWISSPROT-ID: Q11039 
                 1.50E−42 
                  2 
               
               
                   
                   
                   
                 CTGAATCTATC 
                   
                   
                   
                   
                 CODING 
                   
                 ATP-DEPENDENT RNA HELICASE DEAD 
               
               
                   
                   
                   
                 CCA[T/C]TGATC 
                   
                   
                   
                   
                   
                   
                 HOMOLOG -  MYCOBACTERIUM   
               
               
                   
                   
                   
                 TTAGGAGGAG 
                   
                   
                   
                   
                   
                   
                   TUBERCULOSIS , 563 aa. 
               
               
                   
                   
                   
                 GTGATGTACT 
               
               
                 9-10 
                 cg44021557 
                  516 
                 GAAAGACCAAC 
                 gap 
                 A 
                   
                   
                 SILENT- 
                 helicase 
                 Human Gene Similar to SWISSPROT-ID: Q11039 
                 1.50E−42 
                  2 
               
               
                   
                   
                   
                 AGGAAGGCAA 
                   
                   
                   
                   
                 NONCODING 
                   
                 ATP-DEPENDENT RNA HELICASE DEAD 
               
               
                   
                   
                   
                 AAAA[gap/A]GG 
                   
                   
                   
                   
                   
                   
                 HOMOLOG -  MYCOBACTERIUM   
               
               
                   
                   
                   
                 AAAAACAACAA 
                   
                   
                   
                   
                   
                   
                   TUBERCULOSIS , 563 aa. 
               
               
                   
                   
                   
                 TTAAAACTGGT 
               
               
                   
                   
                   
                 G 
               
               
                 11-12 
                 cg43305492 
                  323 
                 TCACCATCACC 
                 A 
                 G 
                 Lys 
                 Lys 
                 SILENT- 
                 immunoglob 
                 Human Gene Similar to TREMBLNEW-ID: 
                 740E−49 
               
               
                   
                   
                   
                 AAGGACACCTC 
                   
                   
                   
                   
                 CODING 
                   
                 G2734101 IMMUNOGLOBULIN HEAVY CHAIN, 
               
               
                   
                   
                   
                 CAA[A/G]AACC 
                   
                   
                   
                   
                   
                   
                 VD(5)J(4) LIKE GENE PRODUCT -  HOMO   
               
               
                   
                   
                   
                 AGGTGGTCCTT 
                   
                   
                   
                   
                   
                   
                   SAPIENS  (HUMAN), 151 aa. 
               
               
                   
                   
                   
                 ACAATGACCA 
               
               
                 13-14 
                 cg43941918 
                  896 
                 GATTAGAACCC 
                 C 
                 T 
                 Gln 
                 Gln 
                 SILENT- 
                 immunoglob 
                 Human Gene Similar to TREMBLNEW-ID: 
                 2.80E−42 
               
               
                   
                   
                   
                 AAATAGATCAG 
                   
                   
                   
                   
                 CODING 
                   
                 G240581 IMMUNOGLOBULIN G2B VARIABLE 
               
               
                   
                   
                   
                 GAG[C/T]TGTG 
                   
                   
                   
                   
                   
                   
                 REGION LIGHT CHAIN, AUTOANTOBODY 
               
               
                   
                   
                   
                 GAGACTGCCCT 
                   
                   
                   
                   
                   
                   
                 BV04-01 VARIABLE REGION LIGHT CHAIN - 
               
               
                   
                   
                   
                 GGCTTCTGCA 
                   
                   
                   
                   
                   
                   
                 MUSSP, 113 aa. 
               
               
                 15-16 
                 cg42312510 
                  235 
                 CTACTTTGGAA 
                 A 
                 G 
                 Ser 
                 Ser 
                 SILENT- 
                 immunoglob 
                 Human Gene Similar to TREMBLNEW-ID: 
                 1.20E−39 
               
               
                   
                   
                   
                 AGTGGGGTCC 
                   
                   
                   
                   
                 CODING 
                   
                 G300839 IMMUNOGLOBULIN LIGHT CHAIN 
               
               
                   
                   
                   
                 CATC[A/G]AGAT 
                   
                   
                   
                   
                   
                   
                 VARIABLE REGION {CLONE ALPHA FOG1- 
               
               
                   
                   
                   
                 TCAGCGGCAG 
                   
                   
                   
                   
                   
                   
                 A4} -  HOMO SAPIENS , 107 aa. 
               
               
                   
                   
                   
                 TGGATCTGGGA 
               
               
                 17-18 
                 cg43147217 
                 2161 
                 TAACCTATTTAT 
                 A 
                 T 
                   
                   
                 SILENT- 
                 interleukin 
                 Human Gene Similar to SWISSPROT-ID: P10145 
                 8.30E−48 
                  4 
               
               
                   
                   
                   
                 TATTTATGTATT 
                   
                   
                   
                   
                 NONCODING 
                   
                 INTERLEUKIN-8 PRECURSOR (IL-8) 
                   
                 (4q12) 
               
               
                   
                   
                   
                 T[A/T]TTTAAGC 
                   
                   
                   
                   
                   
                   
                 (MONOCYTE-DERIVED NEUTROPHIL 
               
               
                   
                   
                   
                 ATCAAATATTT 
                   
                   
                   
                   
                   
                   
                 CHEMOTACTIC FACTOR) (MDNCF) (T-CELL 
               
               
                   
                   
                   
                 GTGCAAG 
                   
                   
                   
                   
                   
                   
                 CHEMOTACTIC FACTOR) (NEUTROPHIL- 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTIVATING PROTEIN 1) (NAP-1) 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (LYMPHOCYTE-DERIVED NEUTROPHIL- 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTIVATING FACTOR) (LYNAP) (PROTEIN 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 3-10C) (NEUTROPHIL-ACTIVATING FACTOR) 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (NAF) (GRANULOCYTE CHEMOTACTIC 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 PROTEIN 1) (GCP-1) (EMOCTAKIN) -  HOMO   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 
                   SAPIENS 
                 
               
               
                 19-20 
                 cg20725546 
                  402 
                 AGGCCGCTGA 
                 T 
                 C 
                 Gly 
                 Gly 
                 SILENT- 
                 kinase 
                 Human Gene Similar to SWISSPROT-ID: O06821 
                 9.40E−42 
               
               
                   
                   
                   
                 CACTCTCGTTA 
                   
                   
                   
                   
                 CODING 
                   
                 PHOSPHOGLYCERATE KINASE (EC 2.7.2.3) - 
               
               
                   
                   
                   
                 TTGG[T/C]GGC 
                   
                   
                   
                   
                   
                   
                   MYCOBACTERIUM TUBERCULOSIS , 412 aa. 
               
               
                   
                   
                   
                 GGTATGGCGTA 
               
               
                   
                   
                   
                 CACCTTCCTCA 
               
               
                 21-22 
                 cg32160481 
                  218 
                 GGGAAATGGC 
                 C 
                 T 
                   
                   
                 SILENT- 
                 MHC 
                 Human Gene Similar to SWISSPROT-ID: P30508 
                 5.60E−37 
               
               
                   
                   
                   
                 CTCTGTGGGG 
                   
                   
                   
                   
                 NONCODING 
                   
                 HLA CLASS HISTOCOMPATIBILITY 
               
               
                   
                   
                   
                 AGGAG[C/T]GA 
                   
                   
                   
                   
                   
                   
                 ANTIGEN, CW*1201 ALPHA CHAIN PRE- 
               
               
                   
                   
                   
                 GGGGCCCGCC 
                   
                   
                   
                   
                   
                   
                 CURSOR (HLA-CX52) -  HOMO SAPIENS   
               
               
                   
                   
                   
                 CGGCGGGGGC 
                   
                   
                   
                   
                   
                   
                 (HUMAN), 366 aa. 
               
               
                   
                   
                   
                 GCA 
               
               
                 23-24 
                 cg29691725 
                  109 
                 CTCGATGTCGC 
                 T 
                 C 
                   
                   
                 SILENT- 
                 nuclease 
                 Human Gene Similar to TREMBLNEW-ID: 
                 1.90E−34 
               
               
                   
                   
                   
                 CCGAGACATG 
                   
                   
                   
                   
                 NONCODING 
                   
                 E1264534 ENDONUCLEASE III - 
               
               
                   
                   
                   
                 GAGA[T/C]CGT 
                   
                   
                   
                   
                   
                   
                   MYCOBACTERIUM TUBERCULOSIS , 226 aa. 
               
               
                   
                   
                   
                 CGGCCCCTCG 
               
               
                   
                   
                   
                 CCAAGGCATTG 
               
               
                   
                   
                   
                 C 
               
               
                 25-26 
                 cg29691725 
                  122 
                 GAGACATGGA 
                 G 
                 A 
                   
                   
                 SILENT- 
                 nuclease 
                 Human Gene Similar to TREMBLNEW-ID: 
                 1.90E−34 
               
               
                   
                   
                   
                 GATCGTCGGC 
                   
                   
                   
                   
                 NONCODING 
                   
                 E1264534 ENDONUCLEASE III - 
               
               
                   
                   
                   
                 CCCTC[G/A]CC 
                   
                   
                   
                   
                   
                   
                   MYCOBACTERIUM TUBERCULOSIS , 226 aa. 
               
               
                   
                   
                   
                 AAGGCATTGCA 
               
               
                   
                   
                   
                 AGCCGTGATC 
               
               
                   
                   
                   
                 GG 
               
               
                 27-28 
                 cg29691725 
                  146 
                 CGCCAAGGCA 
                 G 
                 A 
                   
                   
                 SILENT- 
                 nuclease 
                 Human Gene Similar to TREMBLNEW-ID: 
                 1.90E−34 
               
               
                   
                   
                   
                 TTGCAAGCCGT 
                   
                   
                   
                   
                 NONCODING 
                   
                 E1264534 ENDONUCLEASE III - 
               
               
                   
                   
                   
                 GATC[G/A]GGC 
                   
                   
                   
                   
                   
                   
                   MYCOBACTERIUM TUBERCULOSIS , 226 aa. 
               
               
                   
                   
                   
                 ATGGGCCGGC 
               
               
                   
                   
                   
                 CCTCTGTGGC 
               
               
                   
                   
                   
                 GT 
               
               
                 29-30 
                 cg29691725 
                  169 
                 CGGGCATGGG 
                 gap 
                 C 
                   
                   
                 SILENT- 
                 nuclease 
                 Human Gene Similar to TREMBLNEW-ID: 
                 1.90E−34 
               
               
                   
                   
                   
                 CCGGCCCTCT 
                   
                   
                   
                   
                 NONCODING 
                   
                 E1264534 ENDONUCLEASE III - 
               
               
                   
                   
                   
                 GTGGC[gap/C]G 
                   
                   
                   
                   
                   
                   
                   MYCOBACTERIUM TUBERCULOSIS , 226 aa. 
               
               
                   
                   
                   
                 TCCCGGAACTT 
               
               
                   
                   
                   
                 TTCGCAATCGG 
               
               
                   
                   
                   
                 CC 
               
               
                 31-32 
                 cg29691725 
                  204 
                 CTTTTCGCAAT 
                 A 
                 G 
                   
                   
                 SILENT- 
                 nuclease 
                 Human Gene Similar to TREMBLNEW-ID: 
                 1.90E−34 
               
               
                   
                   
                   
                 CGGCCCCGAC 
                   
                   
                   
                   
                 NONCODING 
                   
                 E1264534 ENDONUCLEASE III - 
               
               
                   
                   
                   
                 GGCA[A/G]ATG 
                   
                   
                   
                   
                   
                   
                   MYCOBACTERIUM TUBERCULOSIS , 226 aa. 
               
               
                   
                   
                   
                 CGAGCACCCC 
               
               
                   
                   
                   
                 GGTATTCCGGC 
               
               
                   
                   
                   
                 A 
               
               
                 33-34 
                 cg29691725 
                  231 
                 TGCGAGCACC 
                 T 
                 C 
                   
                   
                 SILENT- 
                 nuclease 
                 Human Gene Similar to TREMBLNEW-ID: 
                 1.90E−34 
               
               
                   
                   
                   
                 CCGGTATTCCG 
                   
                   
                   
                   
                 NONCODING 
                   
                 E1264534 ENDONUCLEASE III - 
               
               
                   
                   
                   
                 GCAT[T/C]TTCA 
                   
                   
                   
                   
                   
                   
                   MYCOBACTERIUM TUBERCULOSIS , 226 aa. 
               
               
                   
                   
                   
                 CGCTGATGAG 
               
               
                   
                   
                   
                 CTATGCCCGCA 
               
               
                 35-36 
                 cg29691725 
                  232 
                 GCGAGCACCC 
                 T 
                 C 
                   
                   
                 SILENT- 
                 nuclease 
                 Human Gene Similar to TREMBLNEW-ID: 
                 1.90E−34 
               
               
                   
                   
                   
                 CGGTATTCCGG 
                   
                   
                   
                   
                 NONCODING 
                   
                 E1264534 ENDONUCLEASE III - 
               
               
                   
                   
                   
                 CATT[T/C]TCAC 
                   
                   
                   
                   
                   
                   
                   MYCOBACTERIUM TUBERCULOSIS , 226 aa. 
               
               
                   
                   
                   
                 GCTGATGAGCT 
               
               
                   
                   
                   
                 ATGCCCGCAT 
               
               
                 37-38 
                 cg29691725 
                  247 
                 TTCCGGCATTT 
                 T 
                 C 
                   
                   
                 SILENT- 
                 nuclease 
                 Human Gene Similar to TREMBLNEW-ID: 
                 1.90E−34 
               
               
                   
                   
                   
                 TCACGCTGATG 
                   
                   
                   
                   
                 NONCODING 
                   
                 E1264534 ENDONUCLEASE III - 
               
               
                   
                   
                   
                 AGC[T/C]ATGC 
                   
                   
                   
                   
                   
                   
                   MYCOBACTERIUM TUBERCULOSIS , 226 aa. 
               
               
                   
                   
                   
                 CCGCATCTCCC 
               
               
                   
                   
                   
                 CCGCAGCCAG 
               
               
                 39-40 
                 cg29691725 
                  300 
                 AACATCAAGGC 
                 C 
                 T 
                   
                   
                 SILENT- 
                 nuclease 
                 Human Gene Similar to TREMBLNEW-ID: 
                 1.90E−34 
               
               
                   
                   
                   
                 GGCCATCACC 
                   
                   
                   
                   
                 NONCODING 
                   
                 E1264534 ENDONUCLEASE III - 
               
               
                   
                   
                   
                 GCGC[C/T]GAA 
                   
                   
                   
                   
                   
                   
                   MYCOBACTERIUM TUBERCULOSIS , 226 aa. 
               
               
                   
                   
                   
                 AACGTTCATCC 
               
               
                   
                   
                   
                 CCCTCATCGAC 
               
               
                 41-42 
                 cg29691725 
                   
                  80 
                 ACGCCCAGATC 
                 G 
                 A 
                   
                   
                 SILENT- 
                 nuclease 
                 Human Gene Similar to TREMBLNEW-ID: 
                 1.90E−34 
               
               
                   
                   
                   
                 GTCACGACGG 
                   
                   
                   
                   
                 NONCODING 
                   
                 E1264534 ENDONUCLEASE III - 
               
               
                   
                   
                   
                 TCAC[G/A]CCC 
                   
                   
                   
                   
                   
                   
                   MYCOBACTERIUM TUBERCULOSIS , 226 aa. 
               
               
                   
                   
                   
                 CTCGATGTCGC 
               
               
                   
                   
                   
                 CCGAGACATG 
               
               
                   
                   
                   
                 G 
               
               
                 43-44 
                 cg29691725 
                  89 
                 TCGTCACGACG 
                 T 
                 C 
                   
                   
                 SILENT- 
                 nuclease 
                 Human Gene Similar to TREMBLNEW-ID: 
                 1.90E−34 
               
               
                   
                   
                   
                 GTCACGCCCCT 
                   
                   
                   
                   
                 NONCODING 
                   
                 E1264534 ENDONUCLEASE III - 
               
               
                   
                   
                   
                 CGA[T/C]GTCG 
                   
                   
                   
                   
                   
                   
                   MYCOBACTERIUM TUBERCULOSIS , 226 aa. 
               
               
                   
                   
                   
                 CCCGAGACAT 
               
               
                   
                   
                   
                 GGAGATCGTC 
               
               
                   
                   
                   
                 G 
               
               
                 45-46 
                 cg43986329 
                 1496 
                 GGGTTTCCCAT 
                 C 
                 T 
                   
                   
                 SILENT- 
                 protease 
                 Human Gene Similar to SWISSNEW-ID: P55032 
                 2.20E-48 
                 20 
               
               
                   
                   
                   
                 CAGCATTGCCG 
                   
                   
                   
                   
                 NONCODING 
                   
                 MATRILYSIN PRECURSOR (EC 3.4.24.23) 
                   
                 (16q13) 
               
               
                   
                   
                   
                 TCC[C/T]GGGT 
                   
                   
                   
                   
                   
                   
                 (PUMP 1 PROTEASE) (UTERINE METALLO- 
               
               
                   
                   
                   
                 GTAGAGTCTCT 
                   
                   
                   
                   
                   
                   
                 PROTEINASE) (MATRIX METALLO- 
               
               
                   
                   
                   
                 CGCTGGGGCA 
                   
                   
                   
                   
                   
                   
                 PROTEINASE-7) (MMP-7) (MATRIN) -  FELIS   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   SILVESTRIS CATUS  (CAT), 262 aa (fragment).| 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 pcls: SWISSPROT-ID: P55032 MATRILYSIN 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 PRECURSOR (EC 3.4.24.23) (PUMP 1 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 PROTEASE) (UTERINE METALLOPRO- 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TEINASE) (MATRIX METALLOPROTEINASE-7) 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (MMP-7) (MATRIN) -  FELIS SILVESTRIS CATUS   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (CAT), 262 aa (fragment). 
               
               
                 47-48 
                 cg20438082 
                  137 
                 CTTCAACTGCT 
                 A 
                 T 
                 Thr 
                 Thr 
                 SILENT- 
                 ribosomalprot 
                 Human Gene Similar to SWISSPROT-ID: P04447 
                 2.80E−40 
               
               
                   
                   
                   
                 TTAGCAACATC 
                   
                   
                   
                   
                 CODING 
                   
                 50S RIBOSOMAL PROTEIN L1 -  BACILLUS   
               
               
                   
                   
                   
                 CAT[A/T]GTTAC 
                   
                   
                   
                   
                   
                   
                   STEAROTHERMOPHILUS , 232 aa. 
               
               
                   
                   
                   
                 AGTACCAGTTT 
               
               
                   
                   
                   
                 TAGGGTTTG 
               
               
                 49-50 
                 cg20438082 
                  206 
                 CAAGGACACGT 
                 A 
                 T 
                 Leu 
                 Leu 
                 SILENT- 
                 ribosomalprot 
                 Human Gene Similar to SWISSPROT-ID:P04447 
                 2.80E−40 
               
               
                   
                   
                   
                 CCAAGACGTCC 
                   
                   
                   
                   
                 CODING 
                   
                 50S RIBOSOMAL PROTEIN L1 -  BACILLUS   
               
               
                   
                   
                   
                 AAC[A/T]AGAGC 
                   
                   
                   
                   
                   
                   
                   STEAROTHERMOPHILUS , 232 aa. 
               
               
                   
                   
                   
                 CATCATATCAG 
               
               
                   
                   
                   
                 GTGTAGCGA 
               
               
                 51-52 
                 cg39547655 
                  545 
                 GCTGGATCCAC 
                 A 
                 G 
                 Gly 
                 Gly 
                 SILENT- 
                 ribosomalprot 
                 Human Gene Similar to SWISSPROT-ID: P94977 
                 2.30E−38 
               
               
                   
                   
                   
                 AGCGAGCGGA 
                   
                   
                   
                   
                 CODING 
                   
                 50S RIBOSOMAL PROTEIN L20 - 
               
               
                   
                   
                   
                 AGTC[A/G]CCC 
                   
                   
                   
                   
                   
                   
                   MYCOBACTERIUM TUBERCULOSIS , 129 aa.| 
               
               
                   
                   
                   
                 TTCTTAGCACG 
                   
                   
                   
                   
                   
                   
                 pcls: SPTREMBL-ID: P94977 50S RIBOSOMAL 
               
               
                   
                   
                   
                 ACGGTCACGG 
                   
                   
                   
                   
                   
                   
                 PROTEIN L20 - MYCOBACTERIUM 
               
               
                   
                   
                   
                 A 
               
               
                 53-54 
                 cg29358731 
                  181 
                 TCTCGCCTAGG 
                 G 
                 T 
                 Arg 
                 Arg 
                 SILENT- 
                 struct 
                 Human Gene Similar to SWISSPROT-ID: P93087 
                 2.90E−47 
               
               
                   
                   
                   
                 TTGGTCATGAC 
                   
                   
                   
                   
                 CODING 
                   
                 CALMODULIN -  CAPSICUM ANNUUM  (BELL 
               
               
                   
                   
                   
                 ATG[G/T]CGAA 
                   
                   
                   
                   
                   
                   
                 PEPPER), 148 aa. 
               
               
                   
                   
                   
                 GCTCAGCAGC 
               
               
                   
                   
                   
                 GGAGATGAAG 
               
               
                   
                   
                   
                 C 
               
               
                 55-56 
                 cg29358731 
                  196 
                 TCATGACATGG 
                 G 
                 A 
                 Ser 
                 Ser 
                 SILENT- 
                 struct 
                 Human Gene Similar to SWISSPROT-ID: P93087 
                 2.90E−47 
               
               
                   
                   
                   
                 CGAAGCTCAG 
                   
                   
                   
                   
                 CODING 
                   
                 CALMODULIN -  CAPSICUM ANNUUM  (BELL 
               
               
                   
                   
                   
                 CAGC[G/A]GAG 
                   
                   
                   
                   
                   
                   
                 PEPPER), 148 aa. 
               
               
                   
                   
                   
                 ATGAAGCCGTT 
               
               
                   
                   
                   
                 CTGGTCCTTGT 
               
               
                 57-58 
                 cg29358731 
                  229 
                 AGCCGTTCTGG 
                 A 
                 G 
                 Arg 
                 Arg 
                 SILENT- 
                 struct 
                 Human Gene Similar to SWISSPROT-ID: P93087 
                 2.90E−47 
               
               
                   
                   
                   
                 TCCTTGTCGAA 
                   
                   
                   
                   
                 CODING 
                   
                 CALMODULIN -  CAPSICUM ANNUUM  (BELL 
               
               
                   
                   
                   
                 CAC[A/G]CGGA 
                   
                   
                   
                   
                   
                   
                 PEPPER), 148 aa. 
               
               
                   
                   
                   
                 AGGCCTCCTTG 
               
               
                   
                   
                   
                 AGCTCCTCCT 
               
               
                 59-60 
                 cg29358731 
                  301 
                 TGCGTGCCATC 
                 A 
                 G 
                 Pro 
                 Pro 
                 SILENT- 
                 struct 
                 Human Gene Similar to SWISSPROT-ID: P93087 
                 2.90E−47 
               
               
                   
                   
                   
                 AGGTTGAGAAA 
                   
                   
                   
                   
                 CODING 
                   
                 CALMODULIN -  CAPSICUM ANNUUM  (BELL 
               
               
                   
                   
                   
                 CTC[A/G]GGAA 
                   
                   
                   
                   
                   
                   
                 PEPPER), 148 aa. 
               
               
                   
                   
                   
                 AGTCGATGGTT 
               
               
                   
                   
                   
                 CCATTGCCAT 
               
               
                 61-62 
                 cg29358731 
                  304 
                 GTGCCATCAG 
                 A 
                 G 
                 Phe 
                 Phe 
                 SILENT- 
                 struct 
                 Human Gene Similar to SWISSPROT-ID: P93087 
                 2.90E−47 
               
               
                   
                   
                   
                 GTTGAGAAACT 
                   
                   
                   
                   
                 CODING 
                   
                 CALMODULIN -  CAPSICUM ANNUUM  (BELL 
               
               
                   
                   
                   
                 CAGG[A/G]AAG 
                   
                   
                   
                   
                   
                   
                 PEPPER), 148 aa. 
               
               
                   
                   
                   
                 TCGATGGTTCC 
               
               
                   
                   
                   
                 ATTGCCATCAG 
               
               
                 63-64 
                 cg44127439 
                  554 
                 TGCTGCGAAGA 
                 C 
                 T 
                 Glu 
                 Glu 
                 SILENT- 
                 synthase 
                 Human Gene Similar to SWISSPROT-ID: P19206 
                 7.90E−45 
               
               
                   
                   
                   
                 ATCTCGAGGG 
                   
                   
                   
                   
                 CODING 
                   
                 BIOTIN SYNTHASE (EC 2.8.1.6) (BIOTIN 
               
               
                   
                   
                   
                 CCTC[C/T]TCGC 
                   
                   
                   
                   
                   
                   
                 SYNTHETASE) -  BACILLUS SPHAERICUS , 
               
               
                   
                   
                   
                 GGGTAATGGA 
                   
                   
                   
                   
                   
                   
                 332 aa. 
               
               
                   
                   
                   
                 CTCCCCCCTCA 
               
               
                 65-66 
                 cg44127439 
                  704 
                 AGTCCATGAGG 
                 A 
                 G 
                   
                   
                 SILENT- 
                 synthase 
                 Human Gene Similar to SWISSPROT-ID: P19206 
                 7.90E−45 
               
               
                   
                   
                   
                 CAGCACCAATG 
                   
                   
                   
                   
                 NONCODING 
                   
                 BIOTIN SYNTHASE (EC 2.8.1.6) (BIOTIN 
               
               
                   
                   
                   
                 TGG[A/G]CTAC 
                   
                   
                   
                   
                   
                   
                 SYNTHETASE) -  BACILLUS SPHAERICUS , 
               
               
                   
                   
                   
                 CCCCGGAAAT 
                   
                   
                   
                   
                   
                   
                 332 aa. 
               
               
                   
                   
                   
                 GGTGTCGTCGT 
               
               
                 67-68 
                 cg25321479 
                  101 
                 AGAAAGTGTTG 
                 G 
                 A 
                 Ile 
                 Ile 
                 SILENT- 
                 transport 
                 Human Gene Similar to TREMBLNEW-ID: 
                 9.80E−47 
               
               
                   
                   
                   
                 GCTCCCAGGG 
                   
                   
                   
                   
                 CODING 
                   
                 E1245760 PUATIVE COBALT TRANSPORT 
               
               
                   
                   
                   
                 TGGA[G/A]ATTC 
                   
                   
                   
                   
                   
                   
                 PROTEIN -  STREPTOMYCES COELICOLOR , 
               
               
                   
                   
                   
                 CCCCGTGAGC 
                   
                   
                   
                   
                   
                   
                 257 aa. 
               
               
                   
                   
                   
                 CAGGAGCAGG 
               
               
                   
                   
                   
                 G 
               
               
                 69-70 
                 cg25321479 
                  113 
                 CTCCCAGGGT 
                 A 
                 G 
                 Ala 
                 Ala 
                 SILENT- 
                 transport 
                 Human Gene Similar to TREMBLNEW-ID: 
                 9.80E−47 
               
               
                   
                   
                   
                 GGAGATTCCCC 
                   
                   
                   
                   
                 CODING 
                   
                 E1245760 PUATIVE COBALT TRANSPORT 
               
               
                   
                   
                   
                 CGTG[A/G]GCC 
                   
                   
                   
                   
                   
                   
                 PROTEIN -  STREPTOMYCES COELICOLOR , 
               
               
                   
                   
                   
                 AGGAGCAGGG 
                   
                   
                   
                   
                   
                   
                 257 aa. 
               
               
                   
                   
                   
                 CCTGGAAGATG 
               
               
                   
                   
                   
                 A 
               
               
                 71-72 
                 cg25321479 
                  197 
                 GTTTGAACAGT 
                 C 
                 T 
                 Thr 
                 Thr 
                 SILENT- 
                 transport 
                 Human Gene Similar to TREMBLNEW-ID: 
                 9.80E−47 
               
               
                   
                   
                   
                 GCCGCCCCAA 
                   
                   
                   
                   
                 CODING 
                   
                 E1245760 PUATIVE COBALT TRANSPORT 
               
               
                   
                   
                   
                 CTCC[C/T]GTTC 
                   
                   
                   
                   
                   
                   
                 PROTEIN -  STREPTOMYCES COELICOLOR , 
               
               
                   
                   
                   
                 CGGTGGGGTG 
                   
                   
                   
                   
                   
                   
                 257 aa. 
               
               
                   
                   
                   
                 CGAGGACGAT 
               
               
                   
                   
                   
                 C 
               
               
                 73-74 
                 cg25321479 
                  245 
                 ATCCCGTAACG 
                 G 
                 A 
                 Ala 
                 Ala 
                 SILENT- 
                 transport 
                 Human Gene Similar to TREMBLNEW-ID: 
                 9.80E−47 
               
               
                   
                   
                   
                 CTGGGCAGTTT 
                   
                   
                   
                   
                 CODING 
                   
                 E1245760 PUATIVE COBALT TRANSPORT 
               
               
                   
                   
                   
                 GAT[G/A]GCCG 
                   
                   
                   
                   
                   
                   
                 PROTEIN -  STREPTOMYCES COELICOLOR , 
               
               
                   
                   
                   
                 AGAGCACAAAG 
                   
                   
                   
                   
                   
                   
                 257 aa. 
               
               
                   
                   
                   
                 GTGAAAGCGC 
               
               
                 75-76 
                 cg25321479 
                  35 
                 GCCCACGTAGT 
                 A 
                 G 
                 Tyr 
                 Tyr 
                 SILENT- 
                 transport 
                 Human Gene Similar to TREMBLNEW-ID: 
                 9.80E−47 
               
               
                   
                   
                   
                 TTCTTGGTGAG 
                   
                   
                   
                   
                 CODING 
                   
                 E1245760 PUATIVE COBALT TRANSPORT 
               
               
                   
                   
                   
                 CTT[A/G]TAAAA 
                   
                   
                   
                   
                   
                   
                 PROTEIN -  STREPTOMYCES COELICOLOR , 
               
               
                   
                   
                   
                 GGCGTACCCA 
                   
                   
                   
                   
                   
                   
                 257 aa. 
               
               
                   
                   
                   
                 GCCCACGGTC 
               
               
                 77-78 
                 cg25321479 
                  38 
                 CACGTAGTTTC 
                 A 
                 G 
                 Phe 
                 Phe 
                 SILENT- 
                 transport 
                 Human Gene Similar to TREMBLNEW-ID: 
                 9.80E−47 
               
               
                   
                   
                   
                 TTGGTGAGCTT 
                   
                   
                   
                   
                 CODING 
                   
                 E1245760 PUATIVE COBALT TRANSPORT 
               
               
                   
                   
                   
                 ATA[A/G]AAGG 
                   
                   
                   
                   
                   
                   
                 PROTEIN -  STREPTOMYCES COELICOLOR , 
               
               
                   
                   
                   
                 CGTACCCAGC 
                   
                   
                   
                   
                   
                   
                 257 aa. 
               
               
                   
                   
                   
                 CCACGGTCCC 
               
               
                   
                   
                   
                 G 
               
               
                 79-80 
                 cg25321479 
                  83 
                 GTCCCGCGATA 
                 G 
                 A 
                 Asn 
                 Asn 
                 SILENT- 
                 transport 
                 Human Gene Similar to TREMBLNEW-ID: 
                 9.80E−47 
               
               
                   
                   
                   
                 GCCATCGAGAA 
                   
                   
                   
                   
                 CODING 
                   
                 E1245760 PUATIVE COBALT TRANSPORT 
               
               
                   
                   
                   
                 AGT[G/A]TTGG 
                   
                   
                   
                   
                   
                   
                 PROTEIN -  STREPTOMYCES COELICOLOR , 
               
               
                   
                   
                   
                 CTCCCAGGGT 
                   
                   
                   
                   
                   
                   
                 257 aa. 
               
               
                   
                   
                   
                 GGAGATTCCCC 
               
               
                 81-82 
                 cg25321479 
                  14 
                 ACGCGTCAGG 
                 A 
                 G 
                   
                   
                 SILENT- 
                 transport 
                 Human Gene Similar to TREMBLNEW-ID: 
                 9.80E−47 
               
               
                   
                   
                   
                 CCC[A/G]CGTA 
                   
                   
                   
                   
                 NONCODING 
                   
                 E1245760 PUATIVE COBALT TRANSPORT 
               
               
                   
                   
                   
                 GTTTCTTGGTG 
                   
                   
                   
                   
                   
                   
                 PROTEIN -  STREPTOMYCES COELICOLOR , 
               
               
                   
                   
                   
                 AGCTTATAAA 
                   
                   
                   
                   
                   
                   
                 257 aa. 
               
               
                 83-84 
                 cg25321479 
                  17 
                 ACGCGTCAGG 
                 T 
                 A 
                   
                   
                 SILENT- 
                 transport 
                 Human Gene Similar to TREMBLNEW-ID: 
                 9.80E−47 
               
               
                   
                   
                   
                 CCCACG[T/A]A 
                   
                   
                   
                   
                 NONCODING 
                   
                 E1245760 PUATIVE COBALT TRANSPORT 
               
               
                   
                   
                   
                 GTTTCTTGGTG 
                   
                   
                   
                   
                   
                   
                 PROTEIN -  STREPTOMYCES COELICOLOR , 
               
               
                   
                   
                   
                 AGCTTATAAAA 
                   
                   
                   
                   
                   
                   
                 257 aa. 
               
               
                   
                   
                   
                 GG 
               
               
                 85-86 
                 cg39548335 
                  298 
                 CTTCTGTATTC 
                 G 
                 A 
                 Ala 
                 Ala 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: P43618 
                 2.90E−48 
               
               
                   
                   
                   
                 TCGTTGTTACC 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 HYPOTHETICAL 41.3 KD PROTEIN IN SAP155- 
               
               
                   
                   
                   
                 GGC[G/A]GCCT 
                   
                   
                   
                   
                   
                   
                 YMR31 INTERGENIC REGION -  Saccharomyces   
               
               
                   
                   
                   
                 TCCTGGGAGT 
                   
                   
                   
                   
                   
                   
                   cerevisiae  (Baker&#39;s yeast), 361 aa. 
               
               
                   
                   
                   
                 GCTCATTATTC 
               
               
                 87-88 
                 cg43335190 
                  341 
                 GTAGTTCATAT 
                 C 
                 T 
                   
                   
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSNEW-ACC: P32803 
                 7.60E−48 
               
               
                   
                   
                   
                 CTATTTACTTTT 
                   
                   
                   
                   
                 NONCODING 
                 FIED 
                 ENDOSOMAL P24B PROTEIN PRECURSOR 
               
               
                   
                   
                   
                 GC[C/T]TACATA 
                   
                   
                   
                   
                   
                   
                 (24 KD ENDOMEMBRANE PROTEIN) (BASIC 
               
               
                   
                   
                   
                 CGATTACATAC 
                   
                   
                   
                   
                   
                   
                 24 KD LATE ENDOCYTIC INTERMEDIATE 
               
               
                   
                   
                   
                 ACGATTGG 
                   
                   
                   
                   
                   
                   
                 COMPONENT) -  Saccharomyces cerevisiae   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (Baker&#39;s yeast), 203 aa. 
               
               
                 89-90 
                 cg43335190 
                  411 
                 AATTCTCGGTT 
                 T 
                 C 
                   
                   
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSNEW-ACC: P32803 
                 7.60E−48 
               
               
                   
                   
                   
                 TCATACTTTTTA 
                   
                   
                   
                   
                 NONCODING 
                 FIED 
                 ENDOSOMAL P24B PROTEIN PRECURSOR 
               
               
                   
                   
                   
                 CC[T/C]TGATCC 
                   
                   
                   
                   
                   
                   
                 (24 KD ENDOMEMBRANE PROTEIN) (BASIC 
               
               
                   
                   
                   
                 TTCCACTGTTT 
                   
                   
                   
                   
                   
                   
                 24 KD LATE ENDOCYTIC INTERMEDIATE 
               
               
                   
                   
                   
                 TTCCCTGT 
                   
                   
                   
                   
                   
                   
                 COMPONENT) -  Saccharomyces cerevisiae   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (Baker&#39;s yeast), 203 aa. 
               
               
                 91-92 
                 cg43298420 
                  625 
                 GGTGACCGTG 
                 G 
                 T 
                 Pro 
                 Pro 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to TREMBLNEW-ACC: 
                 5.30E−47 
               
               
                   
                   
                   
                 GTCTGAAAGAA 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 MD27784 PTD001 -  HOMO SAPIENS  (HUMAN), 
               
               
                   
                   
                   
                 GGCT[G/T]GGT 
                   
                   
                   
                   
                   
                   
                 218 aa. 
               
               
                   
                   
                   
                 TGAACTGGTAC 
               
               
                   
                   
                   
                 AGCTTCAGGAC 
               
               
                 93-94 
                 cg44928880 
                  161 
                 ACTGAGGTTGG 
                 C 
                 T 
                   
                   
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SPTREMBL-ACC: O17549 
                 5.30E−47 
               
               
                   
                   
                   
                 GTTTCAGACCA 
                   
                   
                   
                   
                 NONCODING 
                 FIED 
                 M18.8 PROTEIN -  CAENORHABDITIS ELEGANS , 
               
               
                   
                   
                   
                 AGA[C/T]ACTG 
                   
                   
                   
                   
                   
                   
                 447 aa. 
               
               
                   
                   
                   
                 GATTCTCCTAG 
               
               
                   
                   
                   
                 TTAAGATAAA 
               
               
                 95-96 
                 cg39410689 
                  99 
                 ATCACCACCAC 
                 C 
                 T 
                 His 
                 His 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: P43638 
                 5.50E−46 
               
               
                   
                   
                   
                 CGCCACCACC 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 MAP-HOMOLOGOUS PROTEIN 1 - 
               
               
                   
                   
                   
                 ATCA[C/T]ACGG 
                   
                   
                   
                   
                   
                   
                   Saccharomyces cerevisiae  (Baker&#39;s yeast), 1398 aa. 
               
               
                   
                   
                   
                 AAGATGCTCCT 
               
               
                   
                   
                   
                 GCACCTAAGA 
               
               
                 97-98 
                 cg20297086 
                  176 
                 TGCACGACAAG 
                 T 
                 C 
                 Asn 
                 Asn 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SPTREMBL-ACC: P95543 
                 9.00E−45 
               
               
                   
                   
                   
                 TACCCGGAGCT 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 ELONGATION FACTOR TU1 -  PLANOBISPORA   
               
               
                   
                   
                   
                 GAA[T/C]GAGG 
                   
                   
                   
                   
                   
                   
                   ROSEA , 397 aa. 
               
               
                   
                   
                   
                 AGTCGCCGTTC 
               
               
                   
                   
                   
                 GACCAGATCG 
               
               
                 99-100 
                 cg20297086 
                  239 
                 AGGAGCGTCA 
                 C 
                 T 
                 Ile 
                 Ile 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SPTREMBL-ACC: P95543 
                 9.00E−45 
               
               
                   
                   
                   
                 GCGCGGCATC 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 ELONGATION FACTOR TU1 -  PLANOBISPORA   
               
               
                   
                   
                   
                 ACCAT[C/T]CG 
                   
                   
                   
                   
                   
                   
                   ROSEA , 397 aa. 
               
               
                   
                   
                   
                 ATCGCCCACAT 
               
               
                   
                   
                   
                 CGAGTACCAGA 
               
               
                 101-102 
                 cg20297086 
                  248 
                 AGCGCGGCAT 
                 C 
                 T 
                 Ala 
                 Ala 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SPTREMBL-ACC: P95543 
                 9.00E−45 
               
               
                   
                   
                   
                 CACCATCTCGA 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 ELONGATION FACTOR TU1 -  PLANOBISPORA   
               
               
                   
                   
                   
                 TCGC[C/T]CACA 
                   
                   
                   
                   
                   
                   
                   ROSEA , 397 aa. 
               
               
                   
                   
                   
                 TCGAGTACCAG 
               
               
                   
                   
                   
                 ACCGAGAAGC 
               
               
                 103-104 
                 cg39386301 
                 1177 
                 TATGTTAATGG 
                 T 
                 C 
                   
                   
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: P32612 
                 1.00E−43 
               
               
                   
                   
                   
                 TGAAGAAATTC 
                   
                   
                   
                   
                 NONCODING 
                 FIED 
                 PAU2 PROTEIN -  Saccharomyces cerevisiae   
               
               
                   
                   
                   
                 ACC[T/C]CCGA 
                   
                   
                   
                   
                   
                   
                 (Baker&#39;s yeast), 120 aa. 
               
               
                   
                   
                   
                 CCGTGGTATGT 
               
               
                   
                   
                   
                 CAATGTGAGA 
               
               
                 105-106 
                 cg39386301 
                  958 
                 ATAATGATAAA 
                 T 
                 C 
                   
                   
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: P32612 
                 1.00E−43 
               
               
                   
                   
                   
                 ATAGTTCGTTC 
                   
                   
                   
                   
                 NONCODING 
                 FIED 
                 PAU2 PROTEIN -  Saccharomyces cerevisiae   
               
               
                   
                   
                   
                 ATA[T/C]ACTCC 
                   
                   
                   
                   
                   
                   
                 (Baker&#39;s yeast), 120 aa. 
               
               
                   
                   
                   
                 GGTGGGATCAT 
               
               
                   
                   
                   
                 TGCAGAAAT 
               
               
                 107-108 
                 cg39515238 
                  192 
                 TCAAGATCTAT 
                 C 
                 A 
                   
                   
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: P53845 
                 3.60E−40 
               
               
                   
                   
                   
                 ATTGCACACCA 
                   
                   
                   
                   
                 NONCODING 
                 FIED 
                 HYPOTHETICAL 35.5 KD PROTEIN IN PIK1- 
               
               
                   
                   
                   
                 GAG[C/A]TGTT 
                   
                   
                   
                   
                   
                   
                 POL2 INTERGENIC REGION -  Saccharomyces   
               
               
                   
                   
                   
                 GTTTTATACTA 
                   
                   
                   
                   
                   
                   
                   cerevisiae  (Baker&#39;s yeast), 314 aa. 
               
               
                   
                   
                   
                 CAACTCATCT 
               
               
                 109-110 
                 cg29693502 
                  181 
                 CAGCGGGGTA 
                 G 
                 A 
                 Tyr 
                 Tyr 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 3.00E−39 
               
               
                   
                   
                   
                 GCGCACCTGAT 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 O10379 PROBABLE GLUTAMATE-AMMONIA- 
               
               
                   
                   
                   
                 CGAC[G/A]TATT 
                   
                   
                   
                   
                   
                   
                 LIGASE ADENYLYLTRANSFERASE 
               
               
                   
                   
                   
                 CCAACAGCTCA 
                   
                   
                   
                   
                   
                   
                 (EC 2.7.7.42) (GLUTAMINE-SYNTHETASE 
               
               
                   
                   
                   
                 TTCGTCAACT 
                   
                   
                   
                   
                   
                   
                 ADENYLYLTRANSFERASE) (ATASE) - 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 Mycobacterium 
               
               
                 111-112 
                 cg29693502 
                  226 
                 TCAACTCCCGG 
                 A 
                 G 
                 Ser 
                 Ser 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 3.00E−39 
               
               
                   
                   
                   
                 TCGCCGGCAC 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 Q10379 PROBABLE GLUTAMATE-AMMONIA- 
               
               
                   
                   
                   
                 CGTG[A/G]CTA 
                   
                   
                   
                   
                   
                   
                 LIGASE ADENYLYLTRANSFERASE 
               
               
                   
                   
                   
                 GCCCGCAGCA 
                   
                   
                   
                   
                   
                   
                 (EC 2.7.7.42) (GLUTAMINE-SYNTHETASE 
               
               
                   
                   
                   
                 GGGCCTGGGA 
                   
                   
                   
                   
                   
                   
                 ADENYLYLTRANSFERASE) (ATASE) - 
               
               
                   
                   
                   
                 TT 
                   
                   
                   
                   
                   
                   
                 Mycobacterium 
               
               
                 113-114 
                 cg29693502 
                  319 
                 CCAGGCTCCG 
                 T 
                 C 
                 Arg 
                 Arg 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 3.00E−39 
               
               
                   
                   
                   
                 TACCATCGGAC 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 Q10379 PROBABLE GLUTAMATE-AMMONIA- 
               
               
                   
                   
                   
                 CGGA[T/C]CGG 
                   
                   
                   
                   
                   
                   
                 LIGASE ADENYLYLTRANSFERASE 
               
               
                   
                   
                   
                 CCTTCCGGGC 
                   
                   
                   
                   
                   
                   
                 (EC 2.7.7.42) (GLUTAMINE-SYNTHETASE 
               
               
                   
                   
                   
                 GCAGATCGGC 
                   
                   
                   
                   
                   
                   
                 ADENYLYLTRANSFERASE) (ATASE) - 
               
               
                   
                   
                   
                 AT 
                   
                   
                   
                   
                   
                   
                 Mycobacterium 
               
               
                 115-116 
                 cg29693502 
                  385 
                 GGTCCGCGCC 
                 G 
                 A 
                 Asn 
                 Asn 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 3.00E−39 
               
               
                   
                   
                   
                 GTGTTTGCCGA 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 Q10379 PROBABLE GLUTAMATE-AMMONIA- 
               
               
                   
                   
                   
                 GCAG[G/A]TTG 
                   
                   
                   
                   
                   
                   
                 LIGASE ADENYLYLTRANSFERASE 
               
               
                   
                   
                   
                 CGTAGCTTAGT 
                   
                   
                   
                   
                   
                   
                 (EC 2.7.7.42) (GLUTAMINE-SYNTHETASE 
               
               
                   
                   
                   
                 GACGATTTTCA 
                   
                   
                   
                   
                   
                   
                 ADENYLYLTRANSFERASE) (ATASE) - 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 Mycobacterium 
               
               
                 117-118 
                 cg29693502 
                  388 
                 CCGCGCCGTG 
                 G 
                 A 
                 Arg 
                 Arg 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 3.00E−39 
               
               
                   
                   
                   
                 TTTGCCGAGCA 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 Q10379 PROBABLE GLUTAMATE-AMMONIA- 
               
               
                   
                   
                   
                 GGTT[G/A]CGT 
                   
                   
                   
                   
                   
                   
                 LIGASE ADENYLYLTRANSFERASE 
               
               
                   
                   
                   
                 AGCTTAGTGAC 
                   
                   
                   
                   
                   
                   
                 (EC 2.7.7.42) (GLUTAMINE-SYNTHETASE 
               
               
                   
                   
                   
                 GATTTTCAGCG 
                   
                   
                   
                   
                   
                   
                 ADENYLYLTRANSFERASE) (ATASE) - 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 Mycobacterium 
               
               
                 119-120 
                 cg29693502 
                  397 
                 GTTTGCCGAGC 
                 A 
                 G 
                 Thr 
                 Thr 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 3.00E−39 
               
               
                   
                   
                   
                 AGGTTGCGTAG 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 Q10379 PROBABLE GLUTAMATE-AMMONIA- 
               
               
                   
                   
                   
                 CTT[A/G]GTGAC 
                   
                   
                   
                   
                   
                   
                 LIGASE ADENYLYLTRANSFERASE 
               
               
                   
                   
                   
                 GATTTTCAGCG 
                   
                   
                   
                   
                   
                   
                 (EC 2.7.7.42) (GLUTAMINE-SYNTHETASE 
               
               
                   
                   
                   
                 CCTTCTCCC 
                   
                   
                   
                   
                   
                   
                 ADENYLYLTRANSFERASE) (ATASE) - 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 Mycobacterium 
               
               
                 121-122 
                 cg29693502 
                  403 
                 CGAGCAGGTT 
                 G 
                 A 
                 Ile 
                 Ile 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 3.00E−39 
               
               
                   
                   
                   
                 GCGTAGCTTAG 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 Q10379 PROBABLE GLUTAMATE-AMMONIA- 
               
               
                   
                   
                   
                 TGAC[G/A]ATTT 
                   
                   
                   
                   
                   
                   
                 LIGASE ADENYLYLTRANSFERASE 
               
               
                   
                   
                   
                 TCAGCGCCTTC 
                   
                   
                   
                   
                   
                   
                 (EC 2.7.7.42) (GLUTAMINE-SYNTHETASE 
               
               
                   
                   
                   
                 TCCCCGACTC 
                   
                   
                   
                   
                   
                   
                 ADENYLYLTRANSFERASE) (ATASE) - 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 Mycobacterium 
               
               
                 123-124 
                 cg43935044 
                  511 
                 GAGTCTGGGG 
                 G 
                 T 
                   
                   
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SPTREMBL-ACC: P70429 
                 3.50E−39 
               
               
                   
                   
                   
                 CTGGCTGGGC 
                   
                   
                   
                   
                 NONCODING 
                 FIED 
                 ENA-VASODILATOR STIMULATED PHOSPHO- 
               
               
                   
                   
                   
                 TTCTG[G/T]CTG 
                   
                   
                   
                   
                   
                   
                 PROTEIN (ENA-VASP LIKE PROTEIN) -  MUS   
               
               
                   
                   
                   
                 TCCTCTGTCGC 
                   
                   
                   
                   
                   
                   
                   MUSCULUS  (MOUSE), 393 aa. 
               
               
                   
                   
                   
                 CGGATGGGCT 
               
               
                   
                   
                   
                 C 
               
               
                 125-126 
                 cg27850036 
                  116 
                 TGAATGGTGGC 
                 G 
                 A 
                 Asp 
                 Asp 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSNEW-ACC: P11653 
                 1.00E−38 
               
               
                   
                   
                   
                 AGACCGGCGT 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 METHYLMALONYL-COA MUTASE ALPHA- 
               
               
                   
                   
                   
                 AGGT[G/A]TCTA 
                   
                   
                   
                   
                   
                   
                 SUBUNIT (EC 5.4.99.2) (MCM-ALPHA) -  
               
               
                   
                   
                   
                 GCCAGTCCATG 
                   
                   
                   
                   
                   
                   
                 
                   Propionibacterium freudenreichii 
                 
               
               
                   
                   
                   
                 TCACCGTAGA 
                   
                   
                   
                   
                   
                   
                   shermanii , 727 aa. 
               
               
                 127-128 
                 cg27850036 
                  14 
                 ACGCGTTGGA 
                 T 
                 C 
                 Lys 
                 Lys 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSNEW-ACC: P11653 
                 1.00E−38 
               
               
                   
                   
                   
                 CTC[T/C]TTAGC 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 METHYLMALONYL-COA MUTASE ALPHA- 
               
               
                   
                   
                   
                 GGTGGAGAAT 
                   
                   
                   
                   
                   
                   
                 SUBUNIT (EC 5.4.99.2) (MCM-ALPHA) - 
               
               
                   
                   
                   
                 CCGGCGTACT 
                   
                   
                   
                   
                   
                   
                   Propionibacterium freudenreichii shermanii , 727 aa. 
               
               
                 129-130 
                 cg27850036 
                  41 
                 TAGCGGTGGA 
                 G 
                 A 
                 Arg 
                 Arg 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSNEW-ACC: P11653 
                 1.00E−38 
               
               
                   
                   
                   
                 GAATCCGGCG 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 METHYLMALONYL-COA MUTASE ALPHA- 
               
               
                   
                   
                   
                 TACTG[G/A]CG 
                   
                   
                   
                   
                   
                   
                 SUBUNIT (EC 5.4.99.2) (MCM-ALPHA) - 
               
               
                   
                   
                   
                 AATCGTCCACG 
                   
                   
                   
                   
                   
                   
                   Propionibacterium freudenreichii shermanii , 727 aa. 
               
               
                   
                   
                   
                 GCCGGAAGGC 
               
               
                   
                   
                   
                 AT 
               
               
                 131-132 
                 cg42331882 
                  466 
                 TGTGCGTAGG 
                 G 
                 A 
                   
                   
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SPTREMBL-ACC: Q15407 
                 1.10E−37 
                 18 
               
               
                   
                   
                   
                 GAAAGTCAGTG 
                   
                   
                   
                   
                 NONCODING 
                 FIED 
                 RTSBETA -  HOMO SAPIENS  (HUMAN), 416 aa. 
               
               
                   
                   
                   
                 TCGT[G/A]CAG 
               
               
                   
                   
                   
                 CTCCCAGGAG 
               
               
                   
                   
                   
                 CCTCCTGAGC 
               
               
                   
                   
                   
                 GT 
               
               
                 133-134 
                 cg43945926 
                  203 
                 ACAACGCGAG 
                 A 
                 G 
                   
                   
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 1.10E−37 
               
               
                   
                   
                   
                 CCAGGAGTACT 
                   
                   
                   
                   
                 NONCODING 
                 FIED 
                 Q06003 GOLIATH PROTEIN (G1 PROTEIN) - 
               
               
                   
                   
                   
                 ACAC[A/G]GCG 
                   
                   
                   
                   
                   
                   
                   Drosophila melanogaster  (Fruit fly), 284 aa. 
               
               
                   
                   
                   
                 CTCATCAACGT 
               
               
                   
                   
                   
                 GACGGTGCAG 
               
               
                   
                   
                   
                 G 
               
               
                 135-136 
                 cg39575634 
                  12 
                 AGATCTGGGAC 
                 A 
                 G 
                 Thr 
                 Thr 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SPTREMBL-ACC: Q63965 
                 3.00E−37 
               
               
                   
                   
                   
                 [A/G]ATGTCTG 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 TRICARBOXYLATE CARRIER -  RATTUS   
               
               
                   
                   
                   
                 GGGAAGTGCC 
                   
                   
                   
                   
                   
                   
                   NORVEGICUS  (RAT), 357 aa (fragment). 
               
               
                   
                   
                   
                 ACCCAACA 
               
               
                 137-138 
                 cg39575634 
                  120 
                 TCTTCACGGTT 
                 C 
                 T 
                 Asn 
                 Asn 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SPTREMBL-ACC: Q63965 
                 3.00E−37 
               
               
                   
                   
                   
                 ACTGATCCCAG 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 TRICARBOXYLATE CARRIER -  RATTUS   
               
               
                   
                   
                   
                 AAA[C/T]ATCCT 
                   
                   
                   
                   
                   
                   
                   NORVEGICUS  (RAT), 357 aa (fragment). 
               
               
                   
                   
                   
                 TTTAACGAACG 
               
               
                   
                   
                   
                 AACAGCTAG 
               
               
                 139-140 
                 cg39575634 
                  165 
                 AGCTAGAGAAT 
                 A 
                 G 
                 Val 
                 Val 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SPTREMBL-ACC: Q63965 
                 3.00E−37 
               
               
                   
                   
                   
                 GCGAGGAAAG 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 TRICARBOXYLATE CARRIER -  RATTUS   
               
               
                   
                   
                   
                 TGGT[A/G]CAC 
                   
                   
                   
                   
                   
                   
                   NORVEGICUS  (RAT), 357 aa (fragment). 
               
               
                   
                   
                   
                 GATTACAGGCA 
               
               
                   
                   
                   
                 AGGAATCGTTC 
               
               
                 141-142 
                 cg39575634 
                  214 
                 TCCTGCCGGC 
                 T 
                 C 
                 Leu 
                 Leu 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SPTREMBL-ACC: Q63965 
                 3.00E−37 
               
               
                   
                   
                   
                 CTCACGGAAAA 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 TRICARBOXYLATE CARRIER -  RATTUS   
               
               
                   
                   
                   
                 TGAG[T/C]TATG 
                   
                   
                   
                   
                   
                   
                   NORVEGICUS  (RAT), 357 aa (fragment). 
               
               
                   
                   
                   
                 GAGAGCGAAG 
               
               
                   
                   
                   
                 TACGCGT 
               
               
                 143-144 
                 cg27826036 
                  118 
                 GTAGGGCGAC 
                 C 
                 T 
                 Glu 
                 Glu 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 3.40E−36 
               
               
                   
                   
                   
                 GGCGTATTTAT 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 Q10776 PUTATIVE LONG-CHAIN-FATTY- 
               
               
                   
                   
                   
                 GTCC[C/T]TCG 
                   
                   
                   
                   
                   
                   
                 ACID--COA LIGASE (EC 6.2.1.3) (LONG-CHAIN 
               
               
                   
                   
                   
                 CCAAGCACGA 
                   
                   
                   
                   
                   
                   
                 ACYLCOA SYNTHETASE) (LACS) - 
               
               
                   
                   
                   
                 CAGCGTTAGAC 
               
               
                   
                   
                   
                 A 
               
               
                 145-146 
                 cg27826036 
                  163 
                 TAGACAGGTAC 
                 G 
                 C 
                 Leu 
                 Leu 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 3.40E−36 
               
               
                   
                   
                   
                 GGGCAGTTGG 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 Q10776 PUTATIVE LONG-CHAIN-FATTY- 
               
               
                   
                   
                   
                 CCAT[G/C]AGA 
                   
                   
                   
                   
                   
                   
                 ACID--COA LIGASE (EC 6.2.1.3) (LONG-CHAIN 
               
               
                   
                   
                   
                 GTGGCCTCGA 
                   
                   
                   
                   
                   
                   
                 ACYLCOA SYNTHETASE) (LACS) - 
               
               
                   
                   
                   
                 CCTTCTGTGGG 
               
               
                   
                   
                   
                 G 
               
               
                 147-148 
                 cg42538578 
                  207 
                 AGAGACATTGC 
                 G 
                 A 
                 Cys 
                 Cys 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 7.40E−34 
                  8 
               
               
                   
                   
                   
                 CCTCCACTGCT 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 Q09753 BETA-DEFENSIN 1 PRECURSOR 
               
               
                   
                   
                   
                 GAC[G/A]CAATT 
                   
                   
                   
                   
                   
                   
                 (HBD-1) (DEFENSIN, BETA 1) -  Homo sapiens   
               
               
                   
                   
                   
                 GTAATGATCAG 
                   
                   
                   
                   
                   
                   
                 (Human), 68 aa. 
               
               
                   
                   
                   
                 ATCTGTGGC 
               
               
                 149-150 
                 cg42538578 
                  365 
                 GGATTTCAGGA 
                 G 
                 A 
                   
                   
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 7.40E−34 
                  8 
               
               
                   
                   
                   
                 ACTGGGGAGA 
                   
                   
                   
                   
                 NONCODING 
                 FIED 
                 Q09753 BETA-DEFENSIN 1 PRECURSOR 
               
               
                   
                   
                   
                 GGCT[G/A]GCT 
                   
                   
                   
                   
                   
                   
                 (HBD-1) (DEFENSIN, BETA 1) -  Homo sapiens   
               
               
                   
                   
                   
                 CCTTTGGAGGC 
                   
                   
                   
                   
                   
                   
                 (Human), 68 aa. 
               
               
                   
                   
                   
                 TGAGCTGACAG 
               
               
                 151-152 
                 cg44002673 
                 1167 
                 AGCAAGCTCTT 
                 A 
                 G 
                   
                   
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: P32740 
                 7.40E−34 
                 13 
               
               
                   
                   
                   
                 TGAAACCTGAG 
                   
                   
                   
                   
                 NONCODING 
                 FIED 
                 HYPOTHETICAL 31.0 KD PROTEIN R107.2 IN 
               
               
                   
                   
                   
                 CCC[A/G]CGCA 
                   
                   
                   
                   
                   
                   
                 CHROMOSOME III -  Caenorhabditis elegans , 
               
               
                   
                   
                   
                 GACCAGAAGTA 
                   
                   
                   
                   
                   
                   
                 285 aa. 
               
               
                   
                   
                   
                 AACAGGCACC 
               
               
                 153-154 
                 cg39710199 
                  535 
                 AGCCGGTGCG 
                 C 
                 T 
                   
                   
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to TREMBLNEW-ACC: 
                 1.20E−33 
               
               
                   
                   
                   
                 GCCTGAGGTG 
                   
                   
                   
                   
                 NONCODING 
                 FIED 
                 CAB50754 PUTATIVE INTEGRAL MEMBRANE 
               
               
                   
                   
                   
                 CGGGG[C/T]GG 
                   
                   
                   
                   
                   
                   
                 TRANSPORT PROTEIN -  STREPTOMYCES   
               
               
                   
                   
                   
                 AGATCGAGTGT 
                   
                   
                   
                   
                   
                   
                   COELICOLOR , 269 aa. 
               
               
                   
                   
                   
                 CGTCATGTCAA 
               
               
                   
                   
                   
                 T 
               
               
                 155-156 
                 cg39710199 
                  736 
                 TGTGGGTAGTG 
                 C 
                 A 
                   
                   
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to TREMBLNEW-ACC: 
                 1.20E−33 
               
               
                   
                   
                   
                 AGCACGACGG 
                   
                   
                   
                   
                 NONCODING 
                 FIED 
                 CAB50754 PUTATIVE INTEGRAL MEMBRANE 
               
               
                   
                   
                   
                 AGAC[C/A]CCG 
                   
                   
                   
                   
                   
                   
                 TRANSPORT PROTEIN -  STREPTOMYCES   
               
               
                   
                   
                   
                 TCATGACGCAT 
                   
                   
                   
                   
                   
                   
                   COELICOLOR , 269 aa. 
               
               
                   
                   
                   
                 TTGCTCAACGA 
               
               
                 157-158 
                 cg38821538 
                  155 
                 ATCACCTGAGG 
                 T 
                 C 
                 Asp 
                 Asp 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: P39195 
                 3.50E−33 
               
               
                   
                   
                   
                 TCCGGAGTTCA 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 !!!! ALU SUBFAMILY SX WARNING ENTRY - 
               
               
                   
                   
                   
                 AGA[T/C]CAGC 
                   
                   
                   
                   
                   
                   
                   Homo sapiens  (Human), 591 aa. 
               
               
                   
                   
                   
                 CTGGCCAACAT 
               
               
                   
                   
                   
                 GATGAAACCC 
               
               
                 159-160 
                 cg21632104 
                  261 
                 CGTCGCAGTAC 
                 A 
                 G 
                 Leu 
                 Leu 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to TREMBLNEW-ACC: 
                 3.00E−32 
               
               
                   
                   
                   
                 GTTCTGGCCTG 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 CAB38487 PUTATIVE HELICASE - 
               
               
                   
                   
                   
                 TCA[A/G]CGTTT 
                   
                   
                   
                   
                   
                   
                   STREPTOMYCES COELICOLOR , 815 aa. 
               
               
                   
                   
                   
                 TGCATATCCCG 
               
               
                   
                   
                   
                 GCAAAGGCC 
               
               
                 161-162 
                 cg20370177 
                  370 
                 CCCAAGCCAAT 
                 A 
                 C 
                 Val 
                 Val 
                 SILENT- 
                 UNCLASSI- 
                 Human Gene Similar to TREMBLNEW-ACC: 
                 1.50E−31 
               
               
                   
                   
                   
                 ACCAAGATGAT 
                   
                   
                   
                   
                 CODING 
                 FIED 
                 CAB49211 HYPOTHETICAL 57.7 KD PROTEIN - 
               
               
                   
                   
                   
                 CGC[A/C]ACTG 
                   
                   
                   
                   
                   
                   
                   PYROCOCCUS ABYSSI , 533 aa. 
               
               
                   
                   
                   
                 GCATCATGTCT 
               
               
                   
                   
                   
                 CCCATGCCTT 
               
               
                 163-164 
                 cg14810223 
                  103 
                 CGAGCAGCCC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCAGGACTCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGCT[A/G]CTG 
               
               
                   
                   
                   
                 GAGATGGGCG 
               
               
                   
                   
                   
                 CCCGGCTATC 
               
               
                   
                   
                   
                 GC 
               
               
                 165-166 
                 cg19882105 
                  125 
                 GAGATCAGTGT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GATGATGCACA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGA[C/T]GGAT 
               
               
                   
                   
                   
                 GCGGGAATCC 
               
               
                   
                   
                   
                 CAGCTCTTCAT 
               
               
                 167-168 
                 cg19882105 
                  131 
                 AGTGTGATGAT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCACAGGACG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GATG[C/T]GGG 
               
               
                   
                   
                   
                 AATCCCAGCTC 
               
               
                   
                   
                   
                 TTCATATGGCT 
               
               
                 169-170 
                 cg19885950 
                  67 
                 TCCTCAAGTCT 
                 G 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TTGTTCAAATAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CA[G/T]CTTTTC 
               
               
                   
                   
                   
                 AGCAAGACCTT 
               
               
                   
                   
                   
                 CATTAACT 
               
               
                 171-172 
                 cg20452710 
                  118 
                 TGGCCTGGAG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGAGGCGGGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGGAC[A/G]CT 
               
               
                   
                   
                   
                 GGCCTGGAGA 
               
               
                   
                   
                   
                 GAGGCGGGAG 
               
               
                   
                   
                   
                 GGA 
               
               
                 173-174 
                 cg20452710 
                  64 
                 GACAGGGGAG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGAGGCGGGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGGAC[A/G]CT 
               
               
                   
                   
                   
                 GGCCTGGAGA 
               
               
                   
                   
                   
                 GAGGCGGGAG 
               
               
                   
                   
                   
                 GGA 
               
               
                 175-176 
                 cg20454325 
                  152 
                 ACATCCCTGCA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTGTCACCAGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCG[A/G]CCCC 
               
               
                   
                   
                   
                 TTGTACCATGG 
               
               
                   
                   
                   
                 CAGGGTTGGG 
               
               
                 177-178 
                 cg20454325 
                  159 
                 TGCACTGTCAC 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CAGCCCGACC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCTT[G/A]TACC 
               
               
                   
                   
                   
                 ATGGCAGGGTT 
               
               
                   
                   
                   
                 GGGCTGACTG 
               
               
                 179-180 
                 cg20595730 
                  225 
                 CTCCAAAGACT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGATTCCAAGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAC[A/G]TCTGT 
               
               
                   
                   
                   
                 GAAATTCACTA 
               
               
                   
                   
                   
                 AGTTTAAGA 
               
               
                 181-182 
                 cg20595730 
                  247 
                 AACATCTGTGA 
                 A 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AATTCACTAAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTT[A/C]AGATA 
               
               
                   
                   
                   
                 TGAAGAGACAG 
               
               
                   
                   
                   
                 ACTAGTTAT 
               
               
                 183-184 
                 cg20610793 
                  156 
                 GGGCCGACCC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GAGCAGATGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTCGT[C/T]ATC 
               
               
                   
                   
                   
                 GAGGACTCCG 
               
               
                   
                   
                   
                 CTTTCGGATTG 
               
               
                   
                   
                   
                 C 
               
               
                 185-186 
                 cg20610793 
                  165 
                 CGAGCAGATGT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTCGTCATCGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGA[C/T]TCCG 
               
               
                   
                   
                   
                 CTTTCGGATTG 
               
               
                   
                   
                   
                 CGTGCCGGAC 
               
               
                 187-188 
                 cg20610793 
                  198 
                 TCGGATTGCGT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCGGACGGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTGC[C/T]GGA 
               
               
                   
                   
                   
                 GCGTGGGTTCT 
               
               
                   
                   
                   
                 CACGGTCGGA 
               
               
                   
                   
                   
                 C 
               
               
                 189-190 
                 cg20610793 
                  228 
                 CGTGGGTTCTC 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACGGTCGGAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCAG[G/A]CTC 
               
               
                   
                   
                   
                 AAGGGCCAGG 
               
               
                   
                   
                   
                 GGGACATGTG 
               
               
                   
                   
                   
                 GG 
               
               
                 191-192 
                 cg20610793 
                  237 
                 TCACGGTCGG 
                 C 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACGCAGGCTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAGGG[C/A]CA 
               
               
                   
                   
                   
                 GGGGGACATG 
               
               
                   
                   
                   
                 TGGGTTCCCG 
               
               
                   
                   
                   
                 GGC 
               
               
                 193-194 
                 cg20610793 
                  267 
                 GGGACATGTG 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGTTCCCGGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTGGA]T/C]GAT 
               
               
                   
                   
                   
                 GAGCGGGTGA 
               
               
                   
                   
                   
                 CCTTCTGGGAA 
               
               
                   
                   
                   
                 C 
               
               
                 195-196 
                 cg20610793 
                  284 
                 GGGCTGGATG 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATGAGCGGGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GACCT[T/C]CTG 
               
               
                   
                   
                   
                 GGAACCCCATC 
               
               
                   
                   
                   
                 GATGAGGGCG 
               
               
                   
                   
                   
                 T 
               
               
                 197-198 
                 cg20610793 
                  296 
                 GAGCGGGTGA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCTTCTGGGAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCCC[A/G]TCG 
               
               
                   
                   
                   
                 ATGAGGGCGT 
               
               
                   
                   
                   
                 GCGAGCTGAC 
               
               
                   
                   
                   
                 AC 
               
               
                 199-200 
                 cg20610793 
                  43 
                 CGGATTGGCCT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CACAAGGCTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCTG[A/G]AAC 
               
               
                   
                   
                   
                 TGTTCGACACC 
               
               
                   
                   
                   
                 GTCCTTGGGGT 
               
               
                 201-202 
                 cg20711459 
                  261 
                 CCCGACTGAA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCACGGATG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGTTC[A/G]CC 
               
               
                   
                   
                   
                 GATCCCATATT 
               
               
                   
                   
                   
                 TGGAGTGGAG 
               
               
                   
                   
                   
                 AG 
               
               
                 203-204 
                 cg20723460 
                  148 
                 TTCCCCGGCG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AAGAAAAAGGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTCG[C/T]CCAT 
               
               
                   
                   
                   
                 TCCTCTTCCAA 
               
               
                   
                   
                   
                 AACGCTACAA 
               
               
                 205-206 
                 cg20723460 
                  193 
                 CTACAACAAAA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACCACCACGCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCC[C/T]TTCCT 
               
               
                   
                   
                   
                 TCTTCCTTGCC 
               
               
                   
                   
                   
                 CCTTTCCCT 
               
               
                 207-208 
                 cg20724182 
                  184 
                 GATCATTGTAG 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCTATTTCAAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACC[G/A]CCAA 
               
               
                   
                   
                   
                 ACAAGCCATGA 
               
               
                   
                   
                   
                 ACGCAGCAAA 
               
               
                 209-210 
                 cg20724182 
                  197 
                 TATTTCAAAAC 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CGCCAAACAAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCA[T/C]GAAC 
               
               
                   
                   
                   
                 GCAGCAAAACA 
               
               
                   
                   
                   
                 ATTCCACTGG 
               
               
                 211-212 
                 cg20724182 
                  95 
                 TGCTGGGGGC 
                 T 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCTTCACAGAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AACA[A/A]CAAA 
               
               
                   
                   
                   
                 TACGCTGTAGC 
               
               
                   
                   
                   
                 TGCCCAATAT 
               
               
                 213-214 
                 cg20724182 
                  99 
                 GGGGGCGCTT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CACAGACAACA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCAA[A/G]TACG 
               
               
                   
                   
                   
                 CTGTAGCTGCC 
               
               
                   
                   
                   
                 CAATATTGGA 
               
               
                 215-216 
                 cg20724478 
                  247 
                 ACTATCTGGGA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTTGGGGCCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGCA[C/T]GGC 
               
               
                   
                   
                   
                 ACTGGAACCAA 
               
               
                   
                   
                   
                 ACCTGAGGCT 
               
               
                   
                   
                   
                 G 
               
               
                 217-218 
                 cg20724478 
                  250 
                 ATCTGGGAGTT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGGGCCCTGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACGG[C/T]ACT 
               
               
                   
                   
                   
                 GGAACCAAACC 
               
               
                   
                   
                   
                 TGAGGCTGGG 
               
               
                   
                   
                   
                 G 
               
               
                 219-220 
                 cg20724478 
                  298 
                 GGGAGCTCGG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCTGGCTGGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATACG[C/T]GAT 
               
               
                   
                   
                   
                 GTCGTCAACGC 
               
               
                   
                   
                   
                 CAGCCCGTGG 
               
               
                   
                   
                   
                 C 
               
               
                 221-222 
                 cg20724478 
                  90 
                 GTTGCCGAAAT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGGGGCCGAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGTG[C/T]CCA 
               
               
                   
                   
                   
                 TGTTGGGCAGT 
               
               
                   
                   
                   
                 CTGACATGCCG 
               
               
                 223-224 
                 cg20726641 
                  101 
                 TCAAGAAATTT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCATTCTTGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCA[C/T]GACCT 
               
               
                   
                   
                   
                 GACCGAGGATT 
               
               
                   
                   
                   
                 CTCACTCAG 
               
               
                 225-226 
                 cg20726641 
                  119 
                 TTGACCACGAC 
                 T 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTGACCGAGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATTC[T/A]CACT 
               
               
                   
                   
                   
                 CAGTGACGAC 
               
               
                   
                   
                   
                 CAGTCTCAAGG 
               
               
                 227-228 
                 cg20726641 
                  224 
                 CTGACGAAAAC 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GATCAACCGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCGC[T/C]TCA 
               
               
                   
                   
                   
                 AAGGGAAGCG 
               
               
                   
                   
                   
                 ACGCTTCATGA 
               
               
                   
                   
                   
                 C 
               
               
                 229-230 
                 cg20726641 
                  280 
                 CTGTCGTCGTC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GATATTCCACT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCG[C/T]TGGT 
               
               
                   
                   
                   
                 CCGATATGGAT 
               
               
                   
                   
                   
                 GCGCAGGGAC 
               
               
                 231-232 
                 cg20726641 
                  307 
                 GGTCCGATATG 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GATGCGCAGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GACA[T/C]GTTA 
               
               
                   
                   
                   
                 ATAACGTTCGT 
               
               
                   
                   
                   
                 ATTAGCGAGC 
               
               
                 233-234 
                 cg20726641 
                  310 
                 CCGATATGGAT 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCGCAGGGAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATGT[T/C]AATA 
               
               
                   
                   
                   
                 ACGTTCGTATT 
               
               
                   
                   
                   
                 AGCGAGCTCG 
               
               
                 235-236 
                 cg20726641 
                  316 
                 TGGATGCGCA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGGACATGTTA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATAA[C/T]GTTC 
               
               
                   
                   
                   
                 GTATTAGCGAG 
               
               
                   
                   
                   
                 CTCGAACA 
               
               
                 237-238 
                 cg20728487 
                  53 
                 GGAAACTCATC 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCAATATCGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGC[T/C]GCTTG 
               
               
                   
                   
                   
                 GGAGACTGGC 
               
               
                   
                   
                   
                 TTCATGCTGG 
               
               
                 239-240 
                 cg20730743 
                  23 
                 ACGCGTACTG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCGGATCTCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GT[A/G]CGATAA 
               
               
                   
                   
                   
                 CCCACCAGATT 
               
               
                   
                   
                   
                 GCCGGTGA 
               
               
                 241-242 
                 cg20730743 
                  26 
                 ACGCGTACTG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCGGATCTCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTACG[A/G]TAA 
               
               
                   
                   
                   
                 CCCACCAGATT 
               
               
                   
                   
                   
                 GCCGGTGAAC 
               
               
                   
                   
                   
                 T 
               
               
                 243-244 
                 cg20730743 
                  95 
                 GCTGTCCGGC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCCACCGGCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGTTT[A/G]TCG 
               
               
                   
                   
                   
                 AGCTGGGAGG 
               
               
                   
                   
                   
                 GATCGATTTTC 
               
               
                   
                   
                   
                 C 
               
               
                 245-246 
                 cg20744814 
                  84 
                 GGCACCCGGG 
                 C 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGCTGCTGGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CATGG[C/gap]C 
               
               
                   
                   
                   
                 ACCCACGAAG 
               
               
                   
                   
                   
                 CTCTCCCTGCC 
               
               
                   
                   
                   
                 CCC 
               
               
                 247-248 
                 cg21147609 
                  219 
                 GTTCCATGCCT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TTCTAGACCCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGG[C/T]CCTTT 
               
               
                   
                   
                   
                 CCTGCATGATT 
               
               
                   
                   
                   
                 TTATCAGCA 
               
               
                 249-250 
                 cg21147791 
                  282 
                 AATAAAGTGTT 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TCCTTGAGTCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGT[G/A]AGTTG 
               
               
                   
                   
                   
                 CTCTAGCAAAT 
               
               
                   
                   
                   
                 TTATCAATC 
               
               
                 251-252 
                 cg21148047 
                  203 
                 ATGGTGATTCC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TCAAGAAATTA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAA[A/G]CAGA 
               
               
                   
                   
                   
                 ATTACCCTATG 
               
               
                   
                   
                   
                 ATCCAGCATT 
               
               
                 253-254 
                 cg21148203 
                  236 
                 TATGTTTGCTG 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGGGAGTGGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGGG[T/C]TGC 
               
               
                   
                   
                   
                 AGAACTTAAGA 
               
               
                   
                   
                   
                 CCAGGACAATT 
               
               
                 255-256 
                 cg21150589 
                  135 
                 CCTTTGAAATT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CGATTTCCTTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCC[A/G]GGTG 
               
               
                   
                   
                   
                 AAAGAGGAGAA 
               
               
                   
                   
                   
                 CAGATTCTAC 
               
               
                 257-258 
                 cg21395558 
                  63 
                 ATTGACAGAGT 
                 G 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GACATTTGGGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAC[G/T]CGTG 
               
               
                   
                   
                   
                 AAGGAAGTGG 
               
               
                   
                   
                   
                 GTGGAGGAGG 
               
               
                   
                   
                   
                 T 
               
               
                 259-260 
                 cg21395558 
                  65 
                 TGACAGAGTGA 
                 G 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CATTTGGGCAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGC[G/T]TGAA 
               
               
                   
                   
                   
                 GGAAGTGGGT 
               
               
                   
                   
                   
                 GGAGGAGGTG 
               
               
                   
                   
                   
                 G 
               
               
                 261-262 
                 cg21395558 
                  72 
                 GTGACATTTGG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCAACGCGTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAGG[A/G]AGT 
               
               
                   
                   
                   
                 GGGTGGAGGA 
               
               
                   
                   
                   
                 GGTGGCAGCC 
               
               
                   
                   
                   
                 AG 
               
               
                 263-264 
                 cg21415668 
                  138 
                 AGGACTGGTCA 
                 C 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGGAGGAGTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGGG[C/G]AGG 
               
               
                   
                   
                   
                 AGGACTGGTCA 
               
               
                   
                   
                   
                 GGGAGGAGTT 
               
               
                   
                   
                   
                 A 
               
               
                 265-266 
                 cg21417734 
                  43 
                 CAACGGGTTAC 
                 C 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCCGGCGCAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTGG[C/G]TTT 
               
               
                   
                   
                   
                 GCCCGATCACA 
               
               
                   
                   
                   
                 GCGGCACGCA 
               
               
                   
                   
                   
                 T 
               
               
                 267-268 
                 cg21428517 
                  142 
                 CCATGCCCATC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCGGTGCCGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGAA[A/G]AAG 
               
               
                   
                   
                   
                 ATTCCTCGATC 
               
               
                   
                   
                   
                 GGCTTTTCCGT 
               
               
                 269-270 
                 cg21428762 
                  113 
                 TGGTCGTGGTC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TCATCAGAGGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAA[A/G]ACGA 
               
               
                   
                   
                   
                 TGAGCGGGGT 
               
               
                   
                   
                   
                 GCTCGGACGC 
               
               
                   
                   
                   
                 A 
               
               
                 271-272 
                 cg21428762 
                  149 
                 GGGTGCTCGG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACGCAGACGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCGAT[A/G]CG 
               
               
                   
                   
                   
                 ACGGGCGGTG 
               
               
                   
                   
                   
                 TCACCGGACTT 
               
               
                   
                   
                   
                 GG 
               
               
                 273-274 
                 cg21428762 
                  65 
                 ACACCGGGGT 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AACGACGGCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGAGC[G/A]CC 
               
               
                   
                   
                   
                 CCAGACCCAG 
               
               
                   
                   
                   
                 GCGAGGGTCT 
               
               
                   
                   
                   
                 TGG 
               
               
                 275-276 
                 cg21429119 
                  356 
                 TTGGTAGGCCA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGGCAGGACG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACCA[C/T]TTGA 
               
               
                   
                   
                   
                 GCCTGGGAATT 
               
               
                   
                   
                   
                 TGAAACCAGC 
               
               
                 277-278 
                 cg21429119 
                  393 
                 AATTTGAAACC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGCCTGGGCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACAT[A/G]GTGA 
               
               
                   
                   
                   
                 GTCTTTGTTTC 
               
               
                   
                   
                   
                 TACAAGAAAT 
               
               
                 279-280 
                 cg21429119 
                  408 
                 TGGGCAACATA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTGAGTCTTTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTT[C/T]TACAA 
               
               
                   
                   
                   
                 GAAATTTAAAA 
               
               
                   
                   
                   
                 AAAAAATTA 
               
               
                 281-282 
                 cg21429803 
                  373 
                 TGCACCCGGC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTGCCCTGAAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CACA[C/T]GCG 
               
               
                   
                   
                   
                 TGTGCCCCGAA 
               
               
                   
                   
                   
                 ATACCTGCATT 
               
               
                 283-284 
                 cg21433543 
                  205 
                 GGTGGATCTG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTCGGGATCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTGAC[C/T]ACT 
               
               
                   
                   
                   
                 CTGGTCATCGT 
               
               
                   
                   
                   
                 CGATTATGCGA 
               
               
                 285-286 
                 cg21433543 
                  239 
                 CATCGTCGATT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATGCGACGAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTTC[C/T]TACC 
               
               
                   
                   
                   
                 ACTGAAGTTAT 
               
               
                   
                   
                   
                 GGCGTCGCTG 
               
               
                 287-288 
                 cg21433543 
                  269 
                 ACTGAAGTTAT 
                 G 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCGTCGCTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGTA[G/gap]CC 
               
               
                   
                   
                   
                 GAGGCTGGGG 
               
               
                   
                   
                   
                 TAGCGCTCCTG 
               
               
                   
                   
                   
                 GG 
               
               
                 289-290 
                 cg21433543 
                  293 
                 AGCCGAGGCT 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGGGTAGCGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCCTG]G/A]GC 
               
               
                   
                   
                   
                 GGAATCGTCCT 
               
               
                   
                   
                   
                 GACGCGGCCG 
               
               
                   
                   
                   
                 CC 
               
               
                 291-292 
                 cg21435199 
                  96 
                 AAATTTAATAAAA 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TAAATTATAAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GA[G/A]CTCCT 
               
               
                   
                   
                   
                 CTTACCTAGAA 
               
               
                   
                   
                   
                 ATAATTATT 
               
               
                 293-294 
                 cg21637172 
                  37 
                 CGGTTGGCCA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGCCTGGCACT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CAAA[C/T]GTCC 
               
               
                   
                   
                   
                 GCCTAACCTGG 
               
               
                   
                   
                   
                 GGTCTTTATT 
               
               
                 295-296 
                 cg21643872 
                  325 
                 GGTTGAGTGG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GACGCCTTCTA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGAG[A/G]AGC 
               
               
                   
                   
                   
                 ACCCTGAGCTT 
               
               
                   
                   
                   
                 GACCTGGAAA 
               
               
                   
                   
                   
                 G 
               
               
                 297-298 
                 cg21657573 
                  102 
                 AAAAAGGTTAA 
                 G 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGATCAGACAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACA[G/C]CTGA 
               
               
                   
                   
                   
                 CCTTACTGCCC 
               
               
                   
                   
                   
                 TCAATGGCCA 
               
               
                 299-300 
                 cg21657879 
                  270 
                 CCAGGGAAAG 
                 C 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCAGTCCCCCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCCC[C/G]ACA 
               
               
                   
                   
                   
                 GCAGTCACGAA 
               
               
                   
                   
                   
                 CCTCAGAAGCC 
               
               
                 301-302 
                 cg21659205 
                  482 
                 CCAAACAATCC 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGCTTGCTCCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTC[G/A]ACCA 
               
               
                   
                   
                   
                 CTCAGAACAAA 
               
               
                   
                   
                   
                 CGCCCTAAGT 
               
               
                 303-304 
                 cg21660634 
                  198 
                 CCACGTGACG 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACCGGAACATC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACTG[T/C]GAC 
               
               
                   
                   
                   
                 GCTTCACTCGG 
               
               
                   
                   
                   
                 GCAACCGGTC 
               
               
                   
                   
                   
                 G 
               
               
                 305-306 
                 cg21660634 
                  92 
                 GCCACGGCTC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGTGAATCCGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTCG[C/T]GGG 
               
               
                   
                   
                   
                 GCCAACACAAC 
               
               
                   
                   
                   
                 GGCCTCACCC 
               
               
                   
                   
                   
                 A 
               
               
                 307-308 
                 cg21661814 
                  164 
                 CGCCGAAATC 
                 C 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGTGACGATG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCCTT[C/G]GC 
               
               
                   
                   
                   
                 GTGGCCAATGT 
               
               
                   
                   
                   
                 GGAGGTAGCC 
               
               
                   
                   
                   
                 GT 
               
               
                 309-310 
                 cg21661814 
                  239 
                 GGACGCGCCC 
                 T 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCGTAGGTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCCTG[T/G]TG 
               
               
                   
                   
                   
                 GATGTCCGCG 
               
               
                   
                   
                   
                 CGMCAACCTG 
               
               
                   
                   
                   
                 AT 
               
               
                 311-312 
                 cg21661814 
                  29 
                 CGTGGACAAC 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTGGGCCGGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAGTA[G/A]CC 
               
               
                   
                   
                   
                 TAACCACTCAA 
               
               
                   
                   
                   
                 TGTCTGCAATG 
               
               
                   
                   
                   
                 A 
               
               
                 313-314 
                 c921661814 
                  52 
                 TAGCCTAACCA 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTCAATGTCTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CAA[T/C]GATCG 
               
               
                   
                   
                   
                 ACTCGACATAC 
               
               
                   
                   
                   
                 TCGGTTTCC 
               
               
                 315-316 
                 cg21661814 
                  98 
                 TTTCCTCGGTG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCTGGATTAGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATC[A/G]TCAAG 
               
               
                   
                   
                   
                 TCTCAGGTTGC 
               
               
                   
                   
                   
                 AGGTGCCGC 
               
               
                 317-318 
                 cg24113982 
                  145 
                 GCTCGGCTGC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGCAGAAGTCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCTT[C/T]CCTC 
               
               
                   
                   
                   
                 CTTTGTGGCTG 
               
               
                   
                   
                   
                 GTATATAGAA 
               
               
                 319-320 
                 cg25268133 
                  209 
                 GGCCGTCATC 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCGGTCACGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTCCC[G/A]TG 
               
               
                   
                   
                   
                 ATCACCATGAT 
               
               
                   
                   
                   
                 CGTGGGCATG 
               
               
                   
                   
                   
                 AC 
               
               
                 321-322 
                 cg25309388 
                  332 
                 TGAGAGGGTAA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGTGCCAGTCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTG[C/T]TAAAA 
               
               
                   
                   
                   
                 GAACGTGAAAA 
               
               
                   
                   
                   
                 GGAAACCTA 
               
               
                 323-324 
                 cg25339094 
                  215 
                 TTGCCCAGACC 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AATGCGATGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTCG[T/C]CTC 
               
               
                   
                   
                   
                 CGCCACCATC 
               
               
                   
                   
                   
                 GAGAAACGAG 
               
               
                   
                   
                   
                 AA 
               
               
                 325-326 
                 cg25339094 
                  345 
                 TGCGAGCCTG 
                 C 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CACACCAACAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCCC[C/A]AGA 
               
               
                   
                   
                   
                 TCGGCGAGTC 
               
               
                   
                   
                   
                 GACCTCTCATC 
               
               
                   
                   
                   
                 G 
               
               
                 327-328 
                 cg25339094 
                  351 
                 CCTGCACACCA 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACAACCCCCAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATC[G/A]GCGA 
               
               
                   
                   
                   
                 GTCGACCTCTC 
               
               
                   
                   
                   
                 ATCGTGCCAG 
               
               
                 329-330 
                 cg27778388 
                  118 
                 GTCCCAGGGT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GACGCGAGGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGGGG[A/G]CT 
               
               
                   
                   
                   
                 GAGCAACCAG 
               
               
                   
                   
                   
                 GAATAGACCTT 
               
               
                   
                   
                   
                 CA 
               
               
                 331-332 
                 cg27802892 
                  239 
                 ATCTAACCGGT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TCTAGACAGCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TAA[A/G]CAAAC 
               
               
                   
                   
                   
                 AGATACAGTGC 
               
               
                   
                   
                   
                 CCTTTTCTC 
               
               
                 333-334 
                 cg27802892 
                  241 
                 CTAACCGGTTC 
                 A 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TAGACAGCTTA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAC[A/C]AACA 
               
               
                   
                   
                   
                 GATACAGTGCC 
               
               
                   
                   
                   
                 CTTTTCTCAG 
               
               
                 335-336 
                 cg27805688 
                  354 
                 AATCCCGTTGC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGTCGTGATGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAA[A/G]CCAG 
               
               
                   
                   
                   
                 CACCAGTTCTG 
               
               
                   
                   
                   
                 CTGGCCACGC 
               
               
                 337-338 
                 cg27825173 
                  254 
                 GGCCACCGCG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCACCGCAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGACA[C/T]CC 
               
               
                   
                   
                   
                 CGACACACGA 
               
               
                   
                   
                   
                 GCACCCACAC 
               
               
                   
                   
                   
                 CCC 
               
               
                 339-340 
                 cg27827050 
                  71 
                 CCGATGGCAA 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTGGGACAGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTGGA[G/A]GG 
               
               
                   
                   
                   
                 CTTGCTCACCT 
               
               
                   
                   
                   
                 GCGAGCCCGG 
               
               
                   
                   
                   
                 CC 
               
               
                 341-342 
                 cg27828294 
                  111 
                 GTACAAAAACT 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGTAGATGTGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAA[T/C]GCAAT 
               
               
                   
                   
                   
                 AAAAGTGCTCA 
               
               
                   
                   
                   
                 GAAACACAC 
               
               
                 343-344 
                 cg27845127 
                  25 
                 ACGCGTCCTGA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGCCGCCGAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCG[A/G]CGAG 
               
               
                   
                   
                   
                 AACAGCAGGC 
               
               
                   
                   
                   
                 CAGCAGCTCG 
               
               
                   
                   
                   
                 A 
               
               
                 345-346 
                 cg27845127 
                  78 
                 TCAGTGGCAGA 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TAGCCAGCGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGAC[T/C]GAG 
               
               
                   
                   
                   
                 CGTGCGCCAT 
               
               
                   
                   
                   
                 GATGCCGCGA 
               
               
                   
                   
                   
                 CT 
               
               
                 347-348 
                 cg27845127 
                  95 
                 GCGGCGACTG 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGCGTGCGCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATGAT[G/A]CC 
               
               
                   
                   
                   
                 GCGACTGACA 
               
               
                   
                   
                   
                 CCACCTGCGG 
               
               
                   
                   
                   
                 TCC 
               
               
                 349-350 
                 cg27922064 
                  325 
                 CAAAAATGCTC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATTTAGTTTTCCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CA[A/G]CACCC 
               
               
                   
                   
                   
                 CCAGACTGACC 
               
               
                   
                   
                   
                 TTCAAAACT 
               
               
                 351-352 
                 cg27928117 
                  11 
                 GCTAGCAGCT 
                 C 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 [C/G]TGGCCCTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CAGCTGAGCA 
               
               
                   
                   
                   
                 CAGGCCA 
               
               
                 353-354 
                 cg27928117 
                  160 
                 TATTCAGTAGG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GAAAAGGGCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGGA[C/T]CTG 
               
               
                   
                   
                   
                 AAAAAAGTGTA 
               
               
                   
                   
                   
                 TTAAGAATCGT 
               
               
                 355-356 
                 cg27929704 
                  206 
                 GTCACTGGGC 
                 G 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTGATGCCACC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGAG[G/gap]CT 
               
               
                   
                   
                   
                 GAGCTACTGG 
               
               
                   
                   
                   
                 GCACCTTCGG 
               
               
                   
                   
                   
                 CCA 
               
               
                 357-358 
                 cg27956615 
                  73 
                 TTCTCCATGCT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCTAGATGGAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAC[A/G]CAGT 
               
               
                   
                   
                   
                 CATTCTGATCA 
               
               
                   
                   
                   
                 CTTTCTCTCT 
               
               
                 359-360 
                 cg27957329 
                  105 
                 GGAGCTATGGT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TTTCGCCAAGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CAA[C/T]TCACT 
               
               
                   
                   
                   
                 GATTGTGGGAC 
               
               
                   
                   
                   
                 GGGTGGTGG 
               
               
                 361-362 
                 cg27962799 
                  121 
                 TGCTCCTCCCG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CGTGCTTCCGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGC[C/T]GGTG 
               
               
                   
                   
                   
                 GCTTGGACCC 
               
               
                   
                   
                   
                 GTCGGGGCTG 
               
               
                   
                   
                   
                 G 
               
               
                 363-364 
                 cg28315794 
                  188 
                 GGTTTAGGAAT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCTAGCTTTTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAA[C/T]TTCAT 
               
               
                   
                   
                   
                 TCAAAATGTCT 
               
               
                   
                   
                   
                 TTGAAGCCA 
               
               
                 365-366 
                 cg28389525 
                  109 
                 TCGTGTTAGAA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AACTTTCGACC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGG[A/G]GTCA 
               
               
                   
                   
                   
                 CGAAGCGTTTG 
               
               
                   
                   
                   
                 GGAGTGGATG 
               
               
                 367-368 
                 cg28389525 
                  145 
                 GTTTGGGAGTG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GATGCGGAAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTGT[A/G]CATA 
               
               
                   
                   
                   
                 AAACCAATCCG 
               
               
                   
                   
                   
                 CGAATAATAT 
               
               
                 369-370 
                 cg28389525 
                  187 
                 GAATAATATAC 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCAGCATTTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGG[T/C]TTCG 
               
               
                   
                   
                   
                 GTCAAGAGGG 
               
               
                   
                   
                   
                 GCCGTTCCGAA 
               
               
                 371-372 
                 cg28389525 
                  91 
                 TCGTTGAGCAT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCAGACGTCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGTT[A/G]GAAA 
               
               
                   
                   
                   
                 ACTTTCGACCT 
               
               
                   
                   
                   
                 GGAGTCACGA 
               
               
                 373-374 
                 cg28397602 
                  82 
                 CCTCTCTGCAC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCTGTGTGTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGC[A/G]TGTC 
               
               
                   
                   
                   
                 CATGCCTGTCC 
               
               
                   
                   
                   
                 AGGTCAGGAC 
               
               
                 375-376 
                 cg28459036 
                  106 
                 GCGACGAGGG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TACGACCGTCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTAG[C/T]CGT 
               
               
                   
                   
                   
                 GTAGATCATAC 
               
               
                   
                   
                   
                 GTCGGGGCCG 
               
               
                   
                   
                   
                 G 
               
               
                 377-378 
                 cg28459036 
                  142 
                 ATACGTCGGG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCGGGTGAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCGCC[A/G]GA 
               
               
                   
                   
                   
                 GGGCTTGCTGT 
               
               
                   
                   
                   
                 TCGGTGGCGG 
               
               
                   
                   
                   
                 TC 
               
               
                 379-380 
                 cg28459036 
                  266 
                 ATCCCGATCCA 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AATCCAGCTAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACC[G/A]ACCAT 
               
               
                   
                   
                   
                 AATCGTCAATG 
               
               
                   
                   
                   
                 CGATCACCA 
               
               
                 381-382 
                 cg28459036 
                  80 
                 AGGCGGCCAA 
                 C 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTCAGCGCAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAGGC[C/G]GC 
               
               
                   
                   
                   
                 GACGAGGGTA 
               
               
                   
                   
                   
                 CGACCGTCGG 
               
               
                   
                   
                   
                 TAG 
               
               
                 383-384 
                 cg28473092 
                  278 
                 CACCCTCGAG 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CATCGTCACCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGAT[G/A]CTAA 
               
               
                   
                   
                   
                 TTAGAGCCATG 
               
               
                   
                   
                   
                 TGCCGATGAG 
               
               
                 385-386 
                 cg28473092 
                  376 
                 GGGGTGCGCC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATACCAACTCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGAC[A/G]CAG 
               
               
                   
                   
                   
                 GACACCCTCG 
               
               
                   
                   
                   
                 CGGAAGTCGAT 
               
               
                   
                   
                   
                 C 
               
               
                 387-388 
                 cg28486260 
                  209 
                 TATTATTTGCTA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TTACCCAAGCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GT[A/G]GGGGC 
               
               
                   
                   
                   
                 TGTCCATTTTTA 
               
               
                   
                   
                   
                 TGCGAAGT 
               
               
                 389-390 
                 cg29195033 
                  109 
                 GTGCAGGCTAA 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TCCACGACATG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TAT[T/C]GACTT 
               
               
                   
                   
                   
                 CCGTCGCGGA 
               
               
                   
                   
                   
                 TCTTGCCGCC 
               
               
                 391-392 
                 cg29195033 
                  333 
                 CAAGCCATTCA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TCGCCGTGCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GACC[A/G]TAG 
               
               
                   
                   
                   
                 TAACCGACCGC 
               
               
                   
                   
                   
                 CGAACCATTGA 
               
               
                 393-394 
                 cg29195033 
                  339 
                 ATTCATCGCCG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGCGGACCATA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTA[A/G]CCGA 
               
               
                   
                   
                   
                 CCGCCGAACC 
               
               
                   
                   
                   
                 ATTGAGGAAGA 
               
               
                 395-396 
                 cg29195033 
                  348 
                 CGTGCGGACC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATAGTAACCGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCGC[C/T]GAA 
               
               
                   
                   
                   
                 CCATTGAGGAA 
               
               
                   
                   
                   
                 GATCCTGCAGC 
               
               
                 397-398 
                 cg29195033 
                  368 
                 ACCGCCGAAC 
                 T 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CATTGAGGAAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATCC[T/G]GCA 
               
               
                   
                   
                   
                 GCGCGGCGAG 
               
               
                   
                   
                   
                 GATGCTAAGGC 
               
               
                   
                   
                   
                 G 
               
               
                 399-400 
                 cg29195033 
                  44 
                 ACGAGGTTCAC 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CGGCCCGCTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATAG[T/C]GTCG 
               
               
                   
                   
                   
                 TCAGTCAGAAT 
               
               
                   
                   
                   
                 CTTCATCATT 
               
               
                 401-402 
                 cg29195033 
                  72 
                 CGTCAGTCAGA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATCTTCATCATT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GC[C/T]GATAC 
               
               
                   
                   
                   
                 GTGATCGTGCA 
               
               
                   
                   
                   
                 GGCTAATCC 
               
               
                 403-404 
                 cg29204207 
                  203 
                 GACACTCCCCT 
                 G 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 14 
               
               
                   
                   
                   
                 CGACGCAGCC 
                   
                   
                   
                   
                 NONCODING 
                   
                   
                   
                 (14q22) 
               
               
                   
                   
                   
                 TCCG[G/T]AGC 
               
               
                   
                   
                   
                 GGCGCGCACT 
               
               
                   
                   
                   
                 CTCCAGAGGC 
               
               
                   
                   
                   
                 CA 
               
               
                 405-406 
                 cg29207528 
                  213 
                 CGGGCCCGCC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTAGCCCTCCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGAT[C/T]CAG 
               
               
                   
                   
                   
                 CGTGGGGACG 
               
               
                   
                   
                   
                 CCAGATCCACG 
               
               
                   
                   
                   
                 T 
               
               
                 407-408 
                 cg29207528 
                  245 
                 GGGGACGCCA 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GATCCACGTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAGAC[G/A]AC 
               
               
                   
                   
                   
                 AGGGTGCCCC 
               
               
                   
                   
                   
                 AGCGCCGTGG 
               
               
                   
                   
                   
                 TCT 
               
               
                 409-410 
                 cg29207528 
                  254 
                 AGATCCACGTG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GAGACGACAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGTG[C/T]CCC 
               
               
                   
                   
                   
                 AGCGCCGTGG 
               
               
                   
                   
                   
                 TCTGGAATCCA 
               
               
                   
                   
                   
                 C 
               
               
                 411-412 
                 cg29207528 
                  260 
                 ACGTGGAGAC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GACAGGGTGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCCAG[C/T]GC 
               
               
                   
                   
                   
                 CGTGGTCTGG 
               
               
                   
                   
                   
                 AATCCACGCTC 
               
               
                   
                   
                   
                 CT 
               
               
                 413-414 
                 cg29207528 
                  413 
                 GCGACCTCAC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CATGTCCACAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGAT[C/T]AGC 
               
               
                   
                   
                   
                 GTCGAAACGTT 
               
               
                   
                   
                   
                 GTGATCGCTGC 
               
               
                 415-416 
                 cg29214234 
                  79 
                 GACGCGTACCT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCATCAGGAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCT[C/T]GTTTG 
               
               
                   
                   
                   
                 TTTCTGAAGCA 
               
               
                   
                   
                   
                 ACCCCCTTC 
               
               
                 417-418 
                 cg29216983 
                  91 
                 CCGTTGGGCC 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATACCCGTCTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTGA[T/C]CGA 
               
               
                   
                   
                   
                 GGAAGGCTCA 
               
               
                   
                   
                   
                 ACGGAATGCAT 
               
               
                   
                   
                   
                 T 
               
               
                 419-420 
                 cg29234854 
                  193 
                 GACGCTGTGC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CGTGGGATTTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTCA[A/G]CGA 
               
               
                   
                   
                   
                 GGCTCAAGAG 
               
               
                   
                   
                   
                 AGGCACGCGT 
               
               
                   
                   
                   
                 CG 
               
               
                 421-422 
                 cg29235319 
                  75 
                 CACACACACAC 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACACACACACA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CAC[G/A]CACG 
               
               
                   
                   
                   
                 CACGCACGCA 
               
               
                   
                   
                   
                 CGCACGCAAT 
               
               
                   
                   
                   
                 G 
               
               
                 423-424 
                 cg29242513 
                  250 
                 TAACGGTTGAG 
                 A 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TAACACATCAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAC[A/C]CCGTT 
               
               
                   
                   
                   
                 CGAGGTCAAG 
               
               
                   
                   
                   
                 CCTGGCGTGT 
               
               
                 425-426 
                 cg29254804 
                  134 
                 TACTTCATTTTT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TTTCCTATTTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CA[A/G]CAACCT 
               
               
                   
                   
                   
                 GTAATGAGTAA 
               
               
                   
                   
                   
                 CTGTATTA 
               
               
                 427-428 
                 cg29345947 
                  298 
                 TAGTGACAGGC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCAATGCACAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGA[A/G]CGGG 
               
               
                   
                   
                   
                 CGCCAACAGA 
               
               
                   
                   
                   
                 GCAGCCACGC 
               
               
                   
                   
                   
                 T 
               
               
                 429-430 
                 cg29352964 
                  401 
                 CGTCTTGCCCA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TATTGACGCCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGA[C/T]GCTG 
               
               
                   
                   
                   
                 CTGTCGGTGTG 
               
               
                   
                   
                   
                 GGGGAGTGAC 
               
               
                 431-432 
                 cg29357657 
                  392 
                 CATGTGAGGA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCCGGCCAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAGGT[C/T]GT 
               
               
                   
                   
                   
                 CGTGCTGGAC 
               
               
                   
                   
                   
                 GACCTATCCGC 
               
               
                   
                   
                   
                 GG 
               
               
                 433-434 
                 cg29360558 
                  158 
                 CGTTTATTTAT 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCTTTTGGTTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTT[T/C]TCCTT 
               
               
                   
                   
                   
                 TGATAAATGCG 
               
               
                   
                   
                   
                 GCCCTTGCT 
               
               
                 435-436 
                 cg29522548 
                  137 
                 CCATAATCATT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TCCAACTCTTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CAA[A/G]GTTTT 
               
               
                   
                   
                   
                 TTTAAATTTCAG 
               
               
                   
                   
                   
                 CTCAAAAT 
               
               
                 437-438 
                 cg30177683 
                  471 
                 GGCTCTATATC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATTGAAAACGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATT[C/T]TCCAC 
               
               
                   
                   
                   
                 GCAAAACCCAC 
               
               
                   
                   
                   
                 TTCACACCA 
               
               
                 439-440 
                 cg30377599 
                  144 
                 TGAGGCATCTA 
                 G 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AATTTTCACAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCT[G/T]CCTGT 
               
               
                   
                   
                   
                 GGAGCAGCAA 
               
               
                   
                   
                   
                 GCTGAAGAAA 
               
               
                 441-442 
                 cg30790712 
                  273 
                 CAGCACCGTG 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGGTCCAGGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCCAC[T/C]GTC 
               
               
                   
                   
                   
                 CACCAGGACCT 
               
               
                   
                   
                   
                 ACTGCGTGGG 
               
               
                   
                   
                   
                 G 
               
               
                 443-444 
                 cg32119538 
                  286 
                 TTCCCTAAATC 
                 A 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CAAAGCGAGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAAC[A/C]GGA 
               
               
                   
                   
                   
                 GAGAGAAACC 
               
               
                   
                   
                   
                 CTGAAAATGGG 
               
               
                   
                   
                   
                 C 
               
               
                 445-446 
                 cg32120712 
                  608 
                 CTCAACAGGTG 
                 G 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTGCACTGGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACCG[G/gap]CA 
               
               
                   
                   
                   
                 GCCGCCCGGG 
               
               
                   
                   
                   
                 GTCCCGCACG 
               
               
                   
                   
                   
                 ACC 
               
               
                 447-448 
                 cg32128189 
                  81 
                 TCAGCTTTATT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATAATCTTATG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGA[C/T]CATCA 
               
               
                   
                   
                   
                 TCATGTATGTG 
               
               
                   
                   
                   
                 GTCCACTGG 
               
               
                 449-450 
                 cg32153241 
                  106 
                 CGGTGCGGCA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCATTCCACCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGAT[C/T]GAC 
               
               
                   
                   
                   
                 CCGGCTCCGG 
               
               
                   
                   
                   
                 TCCCGAGGTC 
               
               
                   
                   
                   
                 CC 
               
               
                 451-452 
                 cg32153241 
                  121 
                 CCACCGCGAT 
                 C 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CGACCCGGCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCGGT[C/A]CC 
               
               
                   
                   
                   
                 GAGGTCCCAC 
               
               
                   
                   
                   
                 AGCAGTTGACC 
               
               
                   
                   
                   
                 AG 
               
               
                 453-454 
                 cg32153241 
                  175 
                 TGGGCCGCAG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCTGCCAGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCGAC[A/G]GC 
               
               
                   
                   
                   
                 TCGTACCGCGT 
               
               
                   
                   
                   
                 GCTTGGTGATA 
               
               
                   
                   
                   
                 A 
               
               
                 455-456 
                 cg32153241 
                  348 
                 AACGCGGGGT 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGGGGAGCCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAGCC[T/C]GT 
               
               
                   
                   
                   
                 GTGACACAATC 
               
               
                   
                   
                   
                 AAGGGGACTC 
               
               
                   
                   
                   
                 GC 
               
               
                 457-458 
                 cg32153241 
                  44 
                 GGTACGTGCG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TTGGCGGCCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCTCA[A/G]CC 
               
               
                   
                   
                   
                 TTGCGTTCTAG 
               
               
                   
                   
                   
                 CCCGATCGCC 
               
               
                   
                   
                   
                 CG 
               
               
                 459-460 
                 cg32153241 
                  55 
                 TGGCGGCCCG 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTCAACCTTGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTTC[T/C]AGCC 
               
               
                   
                   
                   
                 CGATCGCCCG 
               
               
                   
                   
                   
                 ACAGGTCGGG 
               
               
                   
                   
                   
                 T 
               
               
                 461-462 
                 cg32153241 
                  76 
                 GTTCTAGCCCG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATCGCCCGACA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGT[C/T]GGGT 
               
               
                   
                   
                   
                 CGGTGCGGCA 
               
               
                   
                   
                   
                 CCATTCCACCG 
               
               
                 463-464 
                 cg32153241 
                  82 
                 GCCCGATCGC 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCGACAGGTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGGTC[G/A]GT 
               
               
                   
                   
                   
                 GCGGCACCATT 
               
               
                   
                   
                   
                 CCACCGCGAT 
               
               
                   
                   
                   
                 CG 
               
               
                 465-466 
                 cg32168828 
                  367 
                 TAGGGCAACG 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCAAGTTCGAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GACG[T/C]CCC 
               
               
                   
                   
                   
                 CCTGTGCTTTT 
               
               
                   
                   
                   
                 CCGCCTCACTC 
               
               
                 467-468 
                 cg32177197 
                  596 
                 TGACGAGAGTC 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCCTGGGACG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGGG[G/A]AAG 
               
               
                   
                   
                   
                 GAATGGAAAGC 
               
               
                   
                   
                   
                 GGTGGGGTCG 
               
               
                   
                   
                   
                 T 
               
               
                 469-470 
                 cg32177197 
                  716 
                 ATGTACCGTCC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTCCCCTTCCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CAT[A/G]ATCTG 
               
               
                   
                   
                   
                 GAGGCCGTAC 
               
               
                   
                   
                   
                 CAATCGGGTG 
               
               
                 471-472 
                 cg32180618 
                  404 
                 TGTGTGTGAAA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATCAGCACGGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCG[C/T]GTGA 
               
               
                   
                   
                   
                 GGGGCGGGCG 
               
               
                   
                   
                   
                 CGCTTCTCACA 
               
               
                 473-474 
                 cg33206207 
                  74 
                 CAGGGATGAC 
                 G 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCGCCATGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTTGG[G/T]TG 
               
               
                   
                   
                   
                 ACGTGGGCCT 
               
               
                   
                   
                   
                 GCCGACTGTCT 
               
               
                   
                   
                   
                 CC 
               
               
                 475-476 
                 cg34715517 
                  291 
                 TGATGCCTCAG 
                 A 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CAAAAAATTGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCT[A/gap]AAA 
               
               
                   
                   
                   
                 AAAAAAACTGG 
               
               
                   
                   
                   
                 AAGAAAAGTAC 
               
               
                 477-478 
                 cg35050153 
                  456 
                 CGACTTGTTCA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCACCAGGAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAGG[C/T]GCT 
               
               
                   
                   
                   
                 GGCTGCTGTCA 
               
               
                   
                   
                   
                 CTGGGGCTCT 
               
               
                   
                   
                   
                 G 
               
               
                 479-480 
                 cg35066497 
                  449 
                 TGTCGATCTGA 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TCGGAGAACTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCC[G/A]CCGG 
               
               
                   
                   
                   
                 TCTTGTCGTCG 
               
               
                   
                   
                   
                 ACAGTGTTGC 
               
               
                 481-482 
                 cg35066497 
                  469 
                 TTGCCGCCGG 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TCTTGTCGTCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACAG[T/C]GTTG 
               
               
                   
                   
                   
                 CCAGCCTTGTC 
               
               
                   
                   
                   
                 GATGCCCTGC 
               
               
                 483-484 
                 cg35068462 
                  289 
                 GAGGACTCGG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCTGACGACG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTCAC[C/T]GTC 
               
               
                   
                   
                   
                 ATTCATGACCT 
               
               
                   
                   
                   
                 CGACTTGGCTG 
               
               
                 485-486 
                 cg35341776 
                  413 
                 TCAATTGCTTTT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGTCCGACATC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TC[A/G]GACACT 
               
               
                   
                   
                   
                 CTCTTCACCAT 
               
               
                   
                   
                   
                 GACTCAGT 
               
               
                 487-488 
                 cg36508718 
                  517 
                 TGGAGCCCGG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CGACAACCTTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACAT[C/T]ACCG 
               
               
                   
                   
                   
                 TGCATAGCGCC 
               
               
                   
                   
                   
                 CTCAACGATG 
               
               
                 489-490 
                 cg36517624 
                  234 
                 GAACTGGCCC 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGCCAAACTCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCAA[G/A]CTGC 
               
               
                   
                   
                   
                 TGCCTAAAGCC 
               
               
                   
                   
                   
                 TGGGTTGGGG 
               
               
                 491-492 
                 cg36517624 
                  307 
                 TGATGGCTTCA 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGCACGTCCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCCA[G/A]CCT 
               
               
                   
                   
                   
                 AGCCCCGTCA 
               
               
                   
                   
                   
                 CAGTCATCACA 
               
               
                   
                   
                   
                 T 
               
               
                 493-494 
                 cg36517624 
                  453 
                 CATTCTTTGAA 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTGCTTTTTGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGG[G/A]TACCT 
               
               
                   
                   
                   
                 CAGGGGTATCA 
               
               
                   
                   
                   
                 GCGACCGGG 
               
               
                 495-496 
                 cg36517624 
                  475 
                 TGGGTACCTCA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGGGTATCAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGAC[C/T]GGG 
               
               
                   
                   
                   
                 ATGCGAAGGTA 
               
               
                   
                   
                   
                 GGTGATATCCT 
               
               
                 497-498 
                 cg36618790 
                  360 
                 GGCGAAGCAC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTGAGGTCAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAGTT[C/T]GA 
               
               
                   
                   
                   
                 GACCAGCCTG 
               
               
                   
                   
                   
                 GCCAACATGAC 
               
               
                   
                   
                   
                 AA 
               
               
                 499-500 
                 cg37003369 
                  306 
                 TCAGTTGATTT 
                 gap 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AAGGAATAAAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAA[gap/A]GAC 
               
               
                   
                   
                   
                 CATTTTGCTAA 
               
               
                   
                   
                   
                 ACACTATTAAA 
               
               
                 501-502 
                 cg37003369 
                  404 
                 TGTGACCTGTG 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TTCATAGCTAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CAT[G/A]AGCTC 
               
               
                   
                   
                   
                 TGACCTCCCTA 
               
               
                   
                   
                   
                 CGCCGGGCG 
               
               
                 503-504 
                 cg37026709 
                  344 
                 GGCCGTGTGC 
                 C 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGGTACCAGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GATAC[C/G]CA 
               
               
                   
                   
                   
                 GGAGCTCAGC 
               
               
                   
                   
                   
                 AGATTTTGGCC 
               
               
                   
                   
                   
                 TC 
               
               
                 505-506 
                 cg38206730 
                  335 
                 AGGCGTACAC 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTGCAGGTGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTTAC[G/A]TGT 
               
               
                   
                   
                   
                 TCATTTTCGGC 
               
               
                   
                   
                   
                 TCAAGGCGTAC 
               
               
                 507-508 
                 cg38278821 
                  212 
                 CGACGGTACT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGTTGCTCCTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTAT[A/G]GAAA 
               
               
                   
                   
                   
                 GCGGTGAATG 
               
               
                   
                   
                   
                 CGAATGCAATG 
               
               
                 509-510 
                 cg38403377 
                 1024 
                 CGACGATCTCC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCGCGGTGTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTCC[A/G]TAG 
               
               
                   
                   
                   
                 GCGATACCGC 
               
               
                   
                   
                   
                 GAGCATTGACG 
               
               
                   
                   
                   
                 A 
               
               
                 511-512 
                 cg38403377 
                 1084 
                 TCCCCGAACC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTTGACGCCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGAAG[A/G]AC 
               
               
                   
                   
                   
                 ATTGTTGTTGT 
               
               
                   
                   
                   
                 AAATCTTCTTG 
               
               
                   
                   
                   
                 A 
               
               
                 513-514 
                 cg38403377 
                 1171 
                 TCGTTGCGTGC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CGTGAGCGAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCGG[A/G]CGT 
               
               
                   
                   
                   
                 TGCACCGGGT 
               
               
                   
                   
                   
                 CATCCTGCGGT 
               
               
                   
                   
                   
                 G 
               
               
                 515-516 
                 cg38403377 
                  934 
                 CCTCGGTGTGA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTGGCGTTCGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TAG[C/T]AGTGA 
               
               
                   
                   
                   
                 TGCGATGGCG 
               
               
                   
                   
                   
                 GTCGTGCGAT 
               
               
                 517-518 
                 cg38446357 
                  292 
                 TTTCCTCGCTG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGTATCTCCGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAC[C/T]CCTC 
               
               
                   
                   
                   
                 GGGCCCGTAG 
               
               
                   
                   
                   
                 ACCGTCCTCGA 
               
               
                 519-520 
                 cg38446677 
                  312 
                 CACCTCCCATC 
                 G 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGAATGACGTA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGT[G/C]GTCA 
               
               
                   
                   
                   
                 GAGACGATCC 
               
               
                   
                   
                   
                 GACCGTCGTG 
               
               
                   
                   
                   
                 C 
               
               
                 521-522 
                 cg38446677 
                  439 
                 TCGTCGCCGAA 
                 G 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGCAGAATGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCAT[G/C]ACTT 
               
               
                   
                   
                   
                 CGACGGCGGT 
               
               
                   
                   
                   
                 GGCCGAGTCG 
               
               
                   
                   
                   
                 A 
               
               
                 523-524 
                 cg38446677 
                  447 
                 GAAAGCAGAAT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCCATGACTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGA[C/T]GGCG 
               
               
                   
                   
                   
                 GTGGCCGAGT 
               
               
                   
                   
                   
                 CGAGGGCTCC 
               
               
                   
                   
                   
                 G 
               
               
                 525-526 
                 cg38869031 
                  345 
                 ACATTGATTGT 
                 gap 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TCACATTTTTTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TT[gap/T]CTCTT 
               
               
                   
                   
                   
                 CTCAATTTCCC 
               
               
                   
                   
                   
                 TTGATTATA 
               
               
                 527-528 
                 cg38925867 
                  196 
                 GCAACGGAGA 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGACTCACAAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTCG[T/C]TACG 
               
               
                   
                   
                   
                 AGGCGGTAAG 
               
               
                   
                   
                   
                 GCTCACCCGC 
               
               
                   
                   
                   
                 G 
               
               
                 529-530 
                 cg38925867 
                  306 
                 AAGGCCAGTA 
                 G 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCACTCGTGCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTTG[G/C]GAC 
               
               
                   
                   
                   
                 GATGAGACGTT 
               
               
                   
                   
                   
                 GGCCTCGCGG 
               
               
                   
                   
                   
                 C 
               
               
                 531-532 
                 cg39373569 
                  271 
                 AACATCTTGAA 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AATACACAAGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGT[G/A]CAAA 
               
               
                   
                   
                   
                 GATGTGTCACG 
               
               
                   
                   
                   
                 TTCTGGACCT 
               
               
                 533-534 
                 cg39380084 
                  120 
                 CCTCGTTGCCT 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TATCTCCAGAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCC[T/C]CAATT 
               
               
                   
                   
                   
                 TCTGTGAAACG 
               
               
                   
                   
                   
                 TAAACATTA 
               
               
                 535-536 
                 cg39380084 
                  130 
                 TTATCTCCAGA 
                 T 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TTCCTCAATTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTG[T/G]GAAA 
               
               
                   
                   
                   
                 CGTAAACATTA 
               
               
                   
                   
                   
                 TGGGAATAGT 
               
               
                 537-538 
                 cg39402442 
                  172 
                 TTCTTCTCTGC 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CATTCCTGGAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATT[T/C]TGAAA 
               
               
                   
                   
                   
                 AGAGTTGGTAA 
               
               
                   
                   
                   
                 TGTGTTTCA 
               
               
                 539-540 
                 cg39404391 
                  113 
                 TTAGCCCAACA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCTGGCACA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAGG[A/G]CAA 
               
               
                   
                   
                   
                 CAATGAGGAGA 
               
               
                   
                   
                   
                 GGAAAGGGGA 
               
               
                   
                   
                   
                 G 
               
               
                 541-542 
                 cg39404391 
                  48 
                 GATTCCTACAC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TATCCCCAAAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGG[C/T]AGAG 
               
               
                   
                   
                   
                 CTGGGCTCTCC 
               
               
                   
                   
                   
                 CTGCAGTGGC 
               
               
                 543-544 
                 cg39435025 
                  186 
                 AAACTTTAACG 
                 A 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGTTATATCATT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CA[A/T]GGCGT 
               
               
                   
                   
                   
                 AACTTATACGC 
               
               
                   
                   
                   
                 GCGGGGTAC 
               
               
                 545-546 
                 cg39485034 
                  346 
                 CCGCCCAGGA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATTCGTGAGTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCCA[A/G]GTTG 
               
               
                   
                   
                   
                 CTGAGCCATTG 
               
               
                   
                   
                   
                 CCCGGATTCC 
               
               
                 547-548 
                 cg39485034 
                  400 
                 AGTACAGGCG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATCGCTGCCAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGTT[A/G]GAC 
               
               
                   
                   
                   
                 CATGGGAGCA 
               
               
                   
                   
                   
                 GGTAGGACCC 
               
               
                   
                   
                   
                 GC 
               
               
                 549-550 
                 cg39485034 
                  406 
                 GGCGATCGCT 
                 T 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCACCGTTAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACCAT[T/G]GGG 
               
               
                   
                   
                   
                 AGCAGGTAGG 
               
               
                   
                   
                   
                 ACCCGCCTTCC 
               
               
                   
                   
                   
                 T 
               
               
                 551-552 
                 cg39485034 
                  508 
                 GACCCGAGAT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGACTTCTTCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACGA[A/G]GTT 
               
               
                   
                   
                   
                 GCCACGGCTC 
               
               
                   
                   
                   
                 CGTTAGCGAAA 
               
               
                   
                   
                   
                 G 
               
               
                 553-554 
                 cg39485034 
                  519 
                 GACTTCTTCGA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CGAAGTTGCCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGG[C/T]TCCG 
               
               
                   
                   
                   
                 TTAGCGAAAGC 
               
               
                   
                   
                   
                 GATACGGCCG 
               
               
                 555-556 
                 cg39515553 
                  205 
                 CGCACTAAACC 
                 G 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TTAAAAATGCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGA[G/gap]CGC 
               
               
                   
                   
                   
                 ATGCACGGCG 
               
               
                   
                   
                   
                 GACGTCGTGG 
               
               
                   
                   
                   
                 AA 
               
               
                 557-558 
                 cg39515553 
                  88 
                 TGTGTCCGGA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GAAACCTCGTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGGA[A/G]AAC 
               
               
                   
                   
                   
                 AGCGCAAACC 
               
               
                   
                   
                   
                 GCAAAAACCCC 
               
               
                   
                   
                   
                 G 
               
               
                 559-560 
                 cg39516001 
                  168 
                 CGAAATGGAAA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATCGTCAATGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGA[A/G]CCGA 
               
               
                   
                   
                   
                 AATACGATGCT 
               
               
                   
                   
                   
                 AAAGTTATTC 
               
               
                 561-562 
                 cg39517070 
                  164 
                 GCCGCCCAAA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CAACGCTCACC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTTA[C/T]ACGC 
               
               
                   
                   
                   
                 CGCAATCGAG 
               
               
                   
                   
                   
                 GCGTCTCAACC 
               
               
                 563-564 
                 cg39517070 
                  293 
                 TGTTTGCGCTC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CACAGGGGAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGCA[C/T]CGC 
               
               
                   
                   
                   
                 CACTCCATCCA 
               
               
                   
                   
                   
                 CAGCGCAAACA 
               
               
                 565-566 
                 cg39517875 
                  406 
                 GCTGACGGAT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GAACGTCTCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GACAC[A/G]GC 
               
               
                   
                   
                   
                 GGACACCTCA 
               
               
                   
                   
                   
                 GTGAATCTCCC 
               
               
                   
                   
                   
                 TT 
               
               
                 567-568 
                 cg39517875 
                  426 
                 GACACAGCGG 
                 T 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACACCTCAGTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AATC[T/G]CCCT 
               
               
                   
                   
                   
                 TTGAGTAGATA 
               
               
                   
                   
                   
                 CTGGACGAGA 
               
               
                 569-570 
                 cg39523703 
                  182 
                 GCACAGGAGA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCGGCCGAGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCGGG[C/T]GC 
               
               
                   
                   
                   
                 AGCCCCTCCG 
               
               
                   
                   
                   
                 ACATCATGCGC 
               
               
                   
                   
                   
                 AC 
               
               
                 571-572 
                 cg39524728 
                  343 
                 ATATGCATATG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TATGCACTCAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACA[C/T]TCATA 
               
               
                   
                   
                   
                 CATATGTGCCC 
               
               
                   
                   
                   
                 CCTCAGAGA 
               
               
                 573-574 
                 cg39527111 
                  101 
                 GGCGACATGG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCGTCCCCAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGCCC[C/T]GG 
               
               
                   
                   
                   
                 AGGCCGGCAG 
               
               
                   
                   
                   
                 CTGGCGCTGG 
               
               
                   
                   
                   
                 GGA 
               
               
                 575-576 
                 cg39530245 
                  307 
                 GACATTCTCAT 
                 T 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TCAGAGCGGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAAA[T/A]TTCA 
               
               
                   
                   
                   
                 GCAGATTTCAA 
               
               
                   
                   
                   
                 GGAGCCGCCA 
               
               
                 577-578 
                 cg39530249 
                  729 
                 ACAAGCCTTCA 
                 C 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTTTCTTTTCTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TT[C/gap]TTTTT 
               
               
                   
                   
                   
                 TTTTTATCTAAC 
               
               
                   
                   
                   
                 AACTGAAG 
               
               
                 579-580 
                 cg39535150 
                  137 
                 CGGCTCTCCTG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GATGTGCCCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGCA[A/G]CAA 
               
               
                   
                   
                   
                 TGCCAGGTAAG 
               
               
                   
                   
                   
                 CCTTGGTCACG 
               
               
                 581-582 
                 cg39536028 
                  735 
                 CTGGCACACA 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTATCCCAACC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATGG[G/A]TTTA 
               
               
                   
                   
                   
                 GTGTCCACCAG 
               
               
                   
                   
                   
                 ACTTAAAGGA 
               
               
                 583-584 
                 cg39543172 
                  580 
                 ATGTGTCTCCC 
                 A 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACACTGGCCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTGC[A/T]CAAG 
               
               
                   
                   
                   
                 CTGAGAAGCTG 
               
               
                   
                   
                   
                 GGACGGCCCG 
               
               
                 585-586 
                 cg39545648 
                  532 
                 GCAATTTTACT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTACAGCTGAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACA[C/T]TGCCA 
               
               
                   
                   
                   
                 AAGAGTCCAGA 
               
               
                   
                   
                   
                 ATTGTGAAG 
               
               
                 587-588 
                 cg39547799 
                  846 
                 AAAGTTGGAGA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AACAGAAACCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGG[C/T]GAGG 
               
               
                   
                   
                   
                 TGGTCCTTGGT 
               
               
                   
                   
                   
                 TAAGTCTGCA 
               
               
                 589-590 
                 cg39550340 
                  579 
                 TTTTTTTAAATA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACATCGTTGAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TA[A/G]AACAAT 
               
               
                   
                   
                   
                 CCTATTCACTG 
               
               
                   
                   
                   
                 CAGTCACA 
               
               
                 591-592 
                 cg39568672 
                  164 
                 GCTGGGTGGC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGACCAGCGCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTGG[C/T]CAGT 
               
               
                   
                   
                   
                 CAGGGGTTCG 
               
               
                   
                   
                   
                 GTGGAATGTTC 
               
               
                 593-594 
                 cg39568672 
                  248 
                 TACCACGGCAT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CATGGTCGCTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCG[C/T]GCTC 
               
               
                   
                   
                   
                 GTTGGGTACG 
               
               
                   
                   
                   
                 GATGGCTTGC 
               
               
                   
                   
                   
                 G 
               
               
                 595-596 
                 cg39568672 
                  398 
                 TCGGGTATCAG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCGTTGACAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGC[A/G]CCCG 
               
               
                   
                   
                   
                 CTTGTTATCGA 
               
               
                   
                   
                   
                 TTCTCTCATC 
               
               
                 597-598 
                 cg39570661 
                  415 
                 ACGAGGGGAG 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CAAGCACGAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCGGG[G/A]AG 
               
               
                   
                   
                   
                 AGAGCTCTGC 
               
               
                   
                   
                   
                 GCTCGCACAC 
               
               
                   
                   
                   
                 GGG 
               
               
                 599-600 
                 cg39575840 
                  320 
                 CCCATGGTCCT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCCCATGTAAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAG[C/T]TCTG 
               
               
                   
                   
                   
                 GCCAATCAACA 
               
               
                   
                   
                   
                 AGGAGTGGAC 
               
               
                 601-602 
                 cg39575840 
                  361 
                 AGGAGTGGAC 
                 C 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGCTCATACAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGAC[C/G]ACC 
               
               
                   
                   
                   
                 AAGTGGCCAAC 
               
               
                   
                   
                   
                 AAACATAAAGC 
               
               
                 603-604 
                 cg39602316 
                  178 
                 TAGCAGGAGG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AAGCTGATGAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTGA[A/G]GTCC 
               
               
                   
                   
                   
                 GATATAGGCAG 
               
               
                   
                   
                   
                 TTTGTGCTCC 
               
               
                 605-606 
                 cg39704218 
                  348 
                 CAAACTCCTGG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCTCAAGCGAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCT[C/T]CAACC 
               
               
                   
                   
                   
                 CCGGCCTCCC 
               
               
                   
                   
                   
                 AAAGTGCTGG 
               
               
                 607-608 
                 cg41085637 
                  479 
                 AAGACGGCCAT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GAGGAGGCGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGGA[A/G]ACG 
               
               
                   
                   
                   
                 GAGGCCAGCA 
               
               
                   
                   
                   
                 CATCAGGGGA 
               
               
                   
                   
                   
                 GG 
               
               
                 609-610 
                 cg41591473 
                  190 
                 AAATTGACATT 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TAAGTGGACCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCC[G/A]TATTT 
               
               
                   
                   
                   
                 GTATTTGCTAA 
               
               
                   
                   
                   
                 ATCTGGCCA 
               
               
                 611-612 
                 cg41592212 
                  65 
                 ACGCGTGAGC 
                 G 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CACCATGCCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GACGT[G/T]AA 
               
               
                   
                   
                   
                 GACAGGAATTT 
               
               
                   
                   
                   
                 ATACCCATGGA 
               
               
                   
                   
                   
                 G 
               
               
                 613-614 
                 cg41618657 
                  555 
                 CAATTGGCTGT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCTATTTACAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTA[C/T]GTGTC 
               
               
                   
                   
                   
                 ATGTTAAAATA 
               
               
                   
                   
                   
                 ATCATTTCT 
               
               
                 615-616 
                 cg42267484 
                  619 
                 GAACATCCCAT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCAAAAGACTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTC[A/G]AAGG 
               
               
                   
                   
                   
                 GAAGGGCCTG 
               
               
                   
                   
                   
                 GTTTGAGAATG 
               
               
                 617-618 
                 cg42312996 
                  675 
                 TCACCTCCTTC 
                 T 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCTTTATTCTA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCG[T/G]CCCA 
               
               
                   
                   
                   
                 AGGGCCTGAG 
               
               
                   
                   
                   
                 ATTGGGCGACT 
               
               
                 619-620 
                 cg42322469 
                  385 
                 TCCTAAAACCA 
                 A 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TTAGTATCTAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TAA[A/T]TTGAC 
               
               
                   
                   
                   
                 GCTGAAATTTT 
               
               
                   
                   
                   
                 GTATTTTTG 
               
               
                 621-622 
                 cg42327033 
                  94 
                 GGCTTCTCAGG 
                 G 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGTCAGGTGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATTT[G/T]GGCA 
               
               
                   
                   
                   
                 GATGCGCTTGA 
               
               
                   
                   
                   
                 GTGGGGGGGC 
               
               
                 623-624 
                 cg42462046 
                  142 
                 GGCCACAGCG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCCTGCCCCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAGAA[C/T]GG 
               
               
                   
                   
                   
                 CGGGTGGGCT 
               
               
                   
                   
                   
                 GGGTCCGGCT 
               
               
                   
                   
                   
                 GCG 
               
               
                 625-626 
                 cg42462046 
                  98 
                 CCTGCCGCGC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCGGCGGGGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCCTC[C/T]TCG 
               
               
                   
                   
                   
                 CTGTGGGAAAA 
               
               
                   
                   
                   
                 GTGGGGCCAC 
               
               
                   
                   
                   
                 A 
               
               
                 627-628 
                 cg42468895 
                  296 
                 GCCTGGGCAA 
                 G 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CAGAGCAGCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGACT[G/gap]T 
               
               
                   
                   
                   
                 CTTTACACTCG 
               
               
                   
                   
                   
                 GGGTGAGTAG 
               
               
                   
                   
                   
                 TCG 
               
               
                 629-630 
                 cg42518152 
                  110 
                 GACACACATGC 
                 C 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACACGGTTTCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCA[C/G]CACG 
               
               
                   
                   
                   
                 GCTTCTCTCCA 
               
               
                   
                   
                   
                 GCCTTCTCTT 
               
               
                 631-632 
                 cg42534385 
                  391 
                 GCCGCCTACC 
                 G 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACAAGTCGGTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGGC[G/gap]GG 
               
               
                   
                   
                   
                 GGGTGGAGGC 
               
               
                   
                   
                   
                 CAAGCTGCACC 
               
               
                   
                   
                   
                 TG 
               
               
                 633-634 
                 cg42534385 
                  396 
                 TACCACAAGTC 
                 gap 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGTGTGGCGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGGG[gap/G]TG 
               
               
                   
                   
                   
                 GAGGCCAAGC 
               
               
                   
                   
                   
                 TGCACCTGCG 
               
               
                   
                   
                   
                 CCG 
               
               
                 635-636 
                 cg42560726 
                  616 
                 CGCCTGTAATC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TCAGCACTCTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGA[A/G]GTCA 
               
               
                   
                   
                   
                 AGGCAGGTGG 
               
               
                   
                   
                   
                 ATCACTTGAGC 
               
               
                 637-638 
                 cg42656733 
                  325 
                 GGGACCACGA 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGGACTGAGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CAGCT[T/C]TGC 
               
               
                   
                   
                   
                 CCGCCCGCCC 
               
               
                   
                   
                   
                 CCGCGCCCAG 
               
               
                   
                   
                   
                 GG 
               
               
                 639-640 
                 cg42658258 
                  510 
                 GGCCTGCAGA 
                 C 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTCCGGGCCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGGGC[C/gap]A 
               
               
                   
                   
                   
                 CCGGCCTCTC 
               
               
                   
                   
                   
                 CTACCTGCTCC 
               
               
                   
                   
                   
                 TGC 
               
               
                 641-642 
                 cg42673467 
                  656 
                 ATAGACCAACA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATCATGTATCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGC[C/T]ACTTG 
               
               
                   
                   
                   
                 GGATGCCAGC 
               
               
                   
                   
                   
                 ACCCATGCCA 
               
               
                 643-644 
                 cg42691712 
                  697 
                 CCGAGCAGTG 
                 C 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCGCGTGCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGAGT[C/A]CA 
               
               
                   
                   
                   
                 GAGTGGAGCC 
               
               
                   
                   
                   
                 GTGACTCACAA 
               
               
                   
                   
                   
                 TT 
               
               
                 645-646 
                 cg42705180 
                  89 
                 CTTTGGCAAAT 
                 G 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGGGGACTGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGAC[G/T]GGA 
               
               
                   
                   
                   
                 AGGGTGGAGA 
               
               
                   
                   
                   
                 GTAGGCGGAA 
               
               
                   
                   
                   
                 CC 
               
               
                 647-648 
                 cg42705180 
                  96 
                 AAATTGGGGAC 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGAAGACGGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAGG[G/A]TGG 
               
               
                   
                   
                   
                 AGAGTAGGCG 
               
               
                   
                   
                   
                 GAACCAGGTG 
               
               
                   
                   
                   
                 GT 
               
               
                 649-650 
                 cg42718789 
                  107 
                 GAATTCAACAA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CACTATAGAGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CAA[A/G]AGGA 
               
               
                   
                   
                   
                 AACGAGTCGA 
               
               
                   
                   
                   
                 GTGAAACCAGT 
               
               
                 651-652 
                 cg42719781 
                  228 
                 GATTCTGATTT 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TAGTGATGATG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAC[G/A]CTGT 
               
               
                   
                   
                   
                 GGAGAATCCA 
               
               
                   
                   
                   
                 GCAAAAGGAAA 
               
               
                 653-654 
                 cg42848362 
                  34 
                 CATGCAGGCG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CGCCTGTAGTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCAG[C/T]TACT 
               
               
                   
                   
                   
                 CGGGAGGCTG 
               
               
                   
                   
                   
                 ACGCAGGAGA 
               
               
                   
                   
                   
                 A 
               
               
                 655-656 
                 cg42848627 
                  156 
                 TCCTCCATCAC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CAGGCTGTCTA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACG[A/G]GGCT 
               
               
                   
                   
                   
                 GAAGAAGTACC 
               
               
                   
                   
                   
                 ATCCATGAGT 
               
               
                 657-658 
                 cg42895723 
                  781 
                 CAGGGTGCCA 
                 T 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCACTTCTTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AATG[T/G]GTTC 
               
               
                   
                   
                   
                 TTTCTTTATGTG 
               
               
                   
                   
                   
                 ATTATTTGA 
               
               
                 659-660 
                 cg42910590 
                  365 
                 GCCCGGGACG 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGGGAGAATCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCAG[T/C]AGC 
               
               
                   
                   
                   
                 TGAGGACCCC 
               
               
                   
                   
                   
                 ACATGGGGTG 
               
               
                   
                   
                   
                 AG 
               
               
                 661-662 
                 cg42913480 
                  419 
                 ATGTGGGGAAA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGCAAGAGAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATCA[A/G]ATTG 
               
               
                   
                   
                   
                 TTACTGTGTCT 
               
               
                   
                   
                   
                 GTGTAGAAAG 
               
               
                 663-664 
                 cg42919036 
                 1141 
                 GAGGCAGATG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATTCCCAAGAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AACT[C/T]ACCA 
               
               
                   
                   
                   
                 AATCAAGACAA 
               
               
                   
                   
                   
                 ATGTCCTAGA 
               
               
                 665-666 
                 cg42919304 
                  313 
                 GAGGAAGGCA 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AACAGAAAGGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAGG[G/A]CAG 
               
               
                   
                   
                   
                 CAAACCTTTAA 
               
               
                   
                   
                   
                 TGCCTACCTCC 
               
               
                 667-668 
                 cg42922781 
                  404 
                 GAGGCGGGTT 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                  9 
               
               
                   
                   
                   
                 AGTGCCCATG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GATCC[G/A]GT 
               
               
                   
                   
                   
                 GTCTGGGAAG 
               
               
                   
                   
                   
                 GGGCCCACAG 
               
               
                   
                   
                   
                 AAG 
               
               
                 669-670 
                 cg42924993 
                  364 
                 TTTTAGGCCAG 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTGCAGTGGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCAC[A/G]CCCT 
               
               
                   
                   
                   
                 TAATCCCAGCA 
               
               
                   
                   
                   
                 CTTTGGGAGG 
               
               
                 671-672 
                 cg42924993 
                  450 
                 AGACCAGCCT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCCAACATG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTGAA[A/G]CC 
               
               
                   
                   
                   
                 CCGTCTCTACT 
               
               
                   
                   
                   
                 AAAAATACAAA 
               
               
                   
                   
                   
                 A 
               
               
                 673-674 
                 cg42925336 
                  402 
                 TCATGAGGAAG 
                 G 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCAGGACAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTGT[G/T]GCA 
               
               
                   
                   
                   
                 GAGCGGCTTA 
               
               
                   
                   
                   
                 CCCCCATGGC 
               
               
                   
                   
                   
                 AC 
               
               
                 675-676 
                 cg42943021 
                  16 
                 GCGCGCCAGG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACGCC[C/T]GG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTGTTTTGTATT 
               
               
                   
                   
                   
                 TTTAGTAGAGA 
               
               
                 677-678 
                 cg42943021 
                  23 
                 GCGCGCCAGG 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACGCCCGGCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GT[T/C]TTGTAT 
               
               
                   
                   
                   
                 TTTTAGTAGAG 
               
               
                   
                   
                   
                 ACAGGGTT 
               
               
                 679-680 
                 cg42943021 
                  27 
                 CGCGCCAGGA 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CGCCCGGCTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTTTG[T/C]ATT 
               
               
                   
                   
                   
                 TTTAGTAGAGA 
               
               
                   
                   
                   
                 CAGGGTTTTGA 
               
               
                 681-682 
                 cg42943021 
                  68 
                 AGGGTTTTGAG 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGATCTGTCCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCT[T/C]AGCCT 
               
               
                   
                   
                   
                 CCCAAAGTGCT 
               
               
                   
                   
                   
                 GGGATTACA 
               
               
                 683-684 
                 cg42943021 
                  90 
                 CCTTAGCCTCC 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CAAAGTGCTGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAT[T/C]ACAG 
               
               
                   
                   
                   
                 GCATGAGCCA 
               
               
                   
                   
                   
                 CTGTGCCCCG 
               
               
                   
                   
                   
                 C 
               
               
                 685-686 
                 cg43008177 
                  233 
                 ACATCAAATTA 
                 C 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCAATTACCAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGA[C/A]ATGTA 
               
               
                   
                   
                   
                 TTTCATTGAATA 
               
               
                   
                   
                   
                 AATAGCTT 
               
               
                 687-688 
                 cg43008177 
                  280 
                 CTTTTGTTTGTT 
                 gap 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGTTTGTTTGTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 T[gap/G]CAGGG 
               
               
                   
                   
                   
                 AAATTTAGAAC 
               
               
                   
                   
                   
                 AATTATTAG 
               
               
                 689-690 
                 cg43008177 
                  313 
                 ATTTAGAACAA 
                 A 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TTATTAGATGTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AT[A/T]GTGCCT 
               
               
                   
                   
                   
                 CTTCTCGTGTT 
               
               
                   
                   
                   
                 GATACGTG 
               
               
                 691-692 
                 cg43040173 
                  591 
                 GGGAAACCCC 
                 C 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGGGGAGGCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAGGC[C/gap]A 
               
               
                   
                   
                   
                 GCGGGGATTT 
               
               
                   
                   
                   
                 CTGAAGCCAAG 
               
               
                   
                   
                   
                 TGG 
               
               
                 693-694 
                 cg43054295 
                  281 
                 GAGGCTGGCG 
                 C 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 X 
               
               
                   
                   
                   
                 GGCTAGGGCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAGTG[C/G]AG 
               
               
                   
                   
                   
                 CGCCTGCTTAG 
               
               
                   
                   
                   
                 AGACCTTCGG 
               
               
                   
                   
                   
                 GA 
               
               
                 695-696 
                 cg43054295 
                  317 
                 TAGAGACCTTC 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 X 
               
               
                   
                   
                   
                 GGGAGAACTTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGC[C/T]GGAA 
               
               
                   
                   
                   
                 CCCCGACGGC 
               
               
                   
                   
                   
                 TCAGAGGCGC 
               
               
                   
                   
                   
                 C 
               
               
                 697-698 
                 cg43054295 
                  355 
                 GCTCAGAGGC 
                 A 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                 X 
               
               
                   
                   
                   
                 GCCCTGGTGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTCAC[A/C]CTG 
               
               
                   
                   
                   
                 CGGCCCGGCA 
               
               
                   
                   
                   
                 CGCGCGTGGG 
               
               
                   
                   
                   
                 CT 
               
               
                 699-700 
                 cg43060167 
                  673 
                 TTGCCCCCCG 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                  4 
               
               
                   
                   
                   
                 CCAACCTACTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AACC[C/T]CTTC 
               
               
                   
                   
                   
                 CAGATAAAGAC 
               
               
                   
                   
                   
                 AGTGGGCACT 
               
               
                 701-702 
                 cg43076634 
                  27 
                 GCGCGCCTAC 
                 T 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CACGTCAAGCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AATT[T/G]TTTG 
               
               
                   
                   
                   
                 TATTTTAGTAG 
               
               
                   
                   
                   
                 AGGTGGGGTT 
               
               
                 703-704 
                 cg43089031 
                  202 
                 AAATGGGCCA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCGCGGTGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTCAC[A/G]CCT 
               
               
                   
                   
                   
                 ATAATCCCAGC 
               
               
                   
                   
                   
                 ACTTTGGGAGG 
               
               
                 705-706 
                 cg43089031 
                  244 
                 TTTGGGAGGC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CGAGGAGGGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGATC[A/G]CC 
               
               
                   
                   
                   
                 TGAGGTCAGG 
               
               
                   
                   
                   
                 AATTCCAGACC 
               
               
                   
                   
                   
                 AG 
               
               
                 707-708 
                 cg43149120 
                  317 
                 CCAAGAAGAC 
                 T 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 GCTGGAGGGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGCTG[T/C]TA 
               
               
                   
                   
                   
                 GGAGGGACTC 
               
               
                   
                   
                   
                 TGAGCTTCACA 
               
               
                   
                   
                   
                 CC 
               
               
                 709-710 
                 cg43256880 
                  128 
                 GGGAATCTTCT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTTTGACGTAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGG[A/G]AGCC 
               
               
                   
                   
                   
                 TCAGAAAGACA 
               
               
                   
                   
                   
                 TTTTCCTAAT 
               
               
                 711-712 
                 cg43256880 
                  191 
                 GAATGGCCCTA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGATGTTTCCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCG[A/G]AACT 
               
               
                   
                   
                   
                 GGTACTGCTCA 
               
               
                   
                   
                   
                 GCCCTGATCA 
               
               
                 713-714 
                 cg43261262 
                  805 
                 GTGTTTGGATT 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                 16 
               
               
                   
                   
                   
                 TGATCATGGAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTA[G/A]CATAC 
               
               
                   
                   
                   
                 ACCAAAATCCA 
               
               
                   
                   
                   
                 CCGAGACCT 
               
               
                 715-716 
                 cg43276309 
                 1051 
                 TTGGCTTGGGG 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 19 
               
               
                   
                   
                   
                 GGTCCACAGT 
                   
                   
                   
                   
                 NONCODING 
                   
                   
                   
                 (19q13.3) 
               
               
                   
                   
                   
                 GAGG[C/T]AGA 
               
               
                   
                   
                   
                 TGCTGGGCGT 
               
               
                   
                   
                   
                 GAAGAATCTGC 
               
               
                   
                   
                   
                 T 
               
               
                 717-718 
                 cg43276309 
                 1149 
                 GGCCTGGAGG 
                 G 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 19 
               
               
                   
                   
                   
                 GGCCACCAAG 
                   
                   
                   
                   
                 NONCODING 
                   
                   
                   
                 (19q13.3) 
               
               
                   
                   
                   
                 ATGCA[G/T]GA 
               
               
                   
                   
                   
                 GCTGGGCCTG 
               
               
                   
                   
                   
                 GAGAGGCTGC 
               
               
                   
                   
                   
                 AAA 
               
               
                 719-720 
                 cg43276380 
                  686 
                 GTCCACTGTGA 
                 G 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCAGAGGCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGGC[G/C]TGA 
               
               
                   
                   
                   
                 AGAATCTGCTG 
               
               
                   
                   
                   
                 TGAGGCAGAT 
               
               
                   
                   
                   
                 G 
               
               
                 721-722 
                 cg43304080 
                  347 
                 GCCGGGCAGA 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTGGAGCAGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTGGG[G/A]CC 
               
               
                   
                   
                   
                 GTGCCCAGGG 
               
               
                   
                   
                   
                 CGGTGGCTGT 
               
               
                   
                   
                   
                 GAG 
               
               
                 723-724 
                 cg43323676 
                  303 
                 GGTGTGGTGT 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGATTGTAGCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCCC[G/A]AAAC 
               
               
                   
                   
                   
                 TCATGGCGCCT 
               
               
                   
                   
                   
                 CCCCTCGGAC 
               
               
                 725-726 
                 cg43326623 
                  188 
                 GGATAACCAGA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATTATCACAGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACC[C/T]TCTCA 
               
               
                   
                   
                   
                 TTCCCAGCGC 
               
               
                   
                   
                   
                 GTCCTTCTGA 
               
               
                 727-728 
                 cg43328092 
                  168 
                 TTGCTGTGTAA 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                  8 
               
               
                   
                   
                   
                 GAATAGGTCCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCA[A/G]CATGA 
               
               
                   
                   
                   
                 AGATGTGTCTG 
               
               
                   
                   
                   
                 CGTCTGAGC 
               
               
                 729-730 
                 cg43328259 
                  499 
                 AGCCTTCAGG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GAGCGTGGAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACAGG[C/T]TTT 
               
               
                   
                   
                   
                 GAAGACAAGAT 
               
               
                   
                   
                   
                 TCCCAAAAGGA 
               
               
                 731-732 
                 cg43328259 
                  771 
                 ACGGCCATGG 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGACTGCAATT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCAT[T/C]CAGA 
               
               
                   
                   
                   
                 TCACGTTTCTT 
               
               
                   
                   
                   
                 CAATCTGAAG 
               
               
                 733-734 
                 cg43336005 
                  591 
                 GATGTTTGGCT 
                 T 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 22 
               
               
                   
                   
                   
                 GCACGCGAGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCAC[T/G]CGG 
               
               
                   
                   
                   
                 GACAGACCCAA 
               
               
                   
                   
                   
                 GAACACGAATT 
               
               
                 735-736 
                 cg43916688 
                 3263 
                 GCGGCGAGAG 
                 G 
                 gap 
                   
                   
                 SILENT 
                   
                   
                   
                 11 
               
               
                   
                   
                   
                 CGGCTCCTCTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGCA[G/gap]CC 
               
               
                   
                   
                   
                 GGCGCCGGCT 
               
               
                   
                   
                   
                 CCGCTTCCCCT 
               
               
                   
                   
                   
                 TC 
               
               
                 737-738 
                 cg43917746 
                  251 
                 TGGATAGAAGT 
                 T 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                 20 
               
               
                   
                   
                   
                 GCTTCACTAAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGC[T/C]TTATT 
               
               
                   
                   
                   
                 TAAGCATACAA 
               
               
                   
                   
                   
                 GAAAAAAAG 
               
               
                 739-740 
                 cg43917746 
                  471 
                 CAAGCATGGC 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 20 
               
               
                   
                   
                   
                 CCAGCCAGCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCACC[A/G]CC 
               
               
                   
                   
                   
                 CCCAAAACGAA 
               
               
                   
                   
                   
                 CAAAACAAGAG 
               
               
                   
                   
                   
                 A 
               
               
                 741-742 
                 cg43918370 
                  648 
                 TCACCAGGAAA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCTGCCTCCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCG[A/G]GGAC 
               
               
                   
                   
                   
                 CTGCCCGCCT 
               
               
                   
                   
                   
                 CCGGGAGCAG 
               
               
                   
                   
                   
                 C 
               
               
                 743-744 
                 cg43919788 
                 1419 
                 AGGGACATAGA 
                 C 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACCAAGCCCCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGG[C/G]TGCC 
               
               
                   
                   
                   
                 CAGCTACACGA 
               
               
                   
                   
                   
                 CCGCCGCTGG 
               
               
                 745-746 
                 cg43919798 
                  780 
                 ACTCACCTTAT 
                 C 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TCTTCATTTCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCT[C/G]GTGA 
               
               
                   
                   
                   
                 ATCCTCCAGGC 
               
               
                   
                   
                   
                 CTTTCTCTAC 
               
               
                 747-748 
                 cg43921083 
                  318 
                 CAGGCCGGTG 
                 T 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 ACCCCCCATG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAGCC[T/C]CA 
               
               
                   
                   
                   
                 CATGGCGAAG 
               
               
                   
                   
                   
                 AGGATGAGGA 
               
               
                   
                   
                   
                 AGG 
               
               
                 749-750 
                 cg43921103 
                  471 
                 CAGGGAGACG 
                 gap 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCAGCATTAAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAAA[gap/A]GA 
               
               
                   
                   
                   
                 GAGATGTGTTT 
               
               
                   
                   
                   
                 ATTCCATGATC 
               
               
                   
                   
                   
                 A 
               
               
                 751-752 
                 cg43921107 
                  386 
                 GGGTGCTGGC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTTCCTGGCCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGGC[C/T]TTCT 
               
               
                   
                   
                   
                 TCTTGGTGGTC 
               
               
                   
                   
                   
                 GACGCGTATT 
               
               
                 753-754 
                 cg43921619 
                  466 
                 AGAGCTGGAG 
                 G 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 GAGGTATTTGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAAG[G/T]AGC 
               
               
                   
                   
                   
                 AGGGAGAAGA 
               
               
                   
                   
                   
                 GGAGCTGCTG 
               
               
                   
                   
                   
                 AG 
               
               
                 755-756 
                 cg43925523 
                  173 
                 GGATTCTTGGC 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGAAGAATTCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCT[G/A]GAAAT 
               
               
                   
                   
                   
                 ATTTCCCAGGC 
               
               
                   
                   
                   
                 CAAAGGTGG 
               
               
                 757-758 
                 cg43926586 
                  75 
                 ACACCATGCTG 
                 G 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCGTGGTGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAAA[G/gap]CC 
               
               
                   
                   
                   
                 TCCCGAGTCCA 
               
               
                   
                   
                   
                 TACAGATACCA 
               
               
                   
                   
                   
                 C 
               
               
                 759-760 
                 cg43926872 
                  697 
                 TTCTGCGGCC 
                 T 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 19 
               
               
                   
                   
                   
                 GCATCCTGAGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATGG[T/G]GAA 
               
               
                   
                   
                   
                 CACAGATGATG 
               
               
                   
                   
                   
                 TCAACGCCATC 
               
               
                 761-762 
                 cg43927587 
                 4712 
                 GCGGGATGTTT 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                  2 
               
               
                   
                   
                   
                 CTTGGGGGCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCTC[G/A]GGT 
               
               
                   
                   
                   
                 GGAGACACGA 
               
               
                   
                   
                   
                 CACTTTCTACT 
               
               
                   
                   
                   
                 G 
               
               
                 763-764 
                 cg43927587 
                 4793 
                 CTTCCTCCAGC 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                  2 
               
               
                   
                   
                   
                 GGCACAGGGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATTG[C/T]AGAT 
               
               
                   
                   
                   
                 GGGTCACCAG 
               
               
                   
                   
                   
                 CCCCATGTTTT 
               
               
                 765-766 
                 cg43927733 
                  274 
                 CTACACAGGAA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCTGGAAAGAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAC[A/G]AGAT 
               
               
                   
                   
                   
                 GAATGGTTTTG 
               
               
                   
                   
                   
                 GAAGACTTGA 
               
               
                 767-768 
                 cg43927893 
                 1071 
                 AGCATTGGTGC 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCTCATGGCTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATG[T/C]GGAC 
               
               
                   
                   
                   
                 GCAGTAATCCG 
               
               
                   
                   
                   
                 CCACTGTGCA 
               
               
                 769-770 
                 cg43927893 
                 1329 
                 GCCAACATCGA 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCACTCTTTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACC[G/A]GTTG 
               
               
                   
                   
                   
                 CTCATTTTCTG 
               
               
                   
                   
                   
                 GTCTGACCGG 
               
               
                 771-772 
                 cg43929036 
                  299 
                 TGGGCAGCCG 
                 G 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACCCCTTGCAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGCT[G/gap]GC 
               
               
                   
                   
                   
                 CAGCGGCCGC 
               
               
                   
                   
                   
                 CACCACCACAC 
               
               
                   
                   
                   
                 CG 
               
               
                 773-774 
                 cg43929036 
                  300 
                 GGGCAGCCGA 
                 G 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCCCTTGCAGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCTG[G/gap]CC 
               
               
                   
                   
                   
                 AGCGGCCGCC 
               
               
                   
                   
                   
                 ACCACCACACC 
               
               
                   
                   
                   
                 GC 
               
               
                 775-776 
                 cg43929139 
                 2789 
                 TAATCTGTTCA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACCCGAGGTCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTG[A/G]AAACG 
               
               
                   
                   
                   
                 AAGATCAAAAC 
               
               
                   
                   
                   
                 AATAATGAA 
               
               
                 777-778 
                 cg43929139 
                 2828 
                 AACAATAATGA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACCAGAGAGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAAT[C/T]TTGG 
               
               
                   
                   
                   
                 GATGATTTCTA 
               
               
                   
                   
                   
                 TCATTGCACA 
               
               
                 779-780 
                 cg43929139 
                 2834 
                 AATGAACCAGA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GAGCGAATCTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGG[A/G]TGAT 
               
               
                   
                   
                   
                 TTCTATCATTG 
               
               
                   
                   
                   
                 CACATACAAA 
               
               
                 781-782 
                 cg43929139 
                 2861 
                 GATTTCTATCA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TTGCACATACA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAT[A/G]ATGG 
               
               
                   
                   
                   
                 GAATTTTAGTA 
               
               
                   
                   
                   
                 TGTTTTATCA 
               
               
                 783-784 
                 cg43929652 
                  984 
                 CACTTGTTAGG 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 CTCTTGTCAGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATT[G/A]ATAAC 
               
               
                   
                   
                   
                 TGGCATGTTTT 
               
               
                   
                   
                   
                 ATTGCAGCC 
               
               
                 785-786 
                 cg43929990 
                 1931 
                 GTGTTAACTTG 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 10 
               
               
                   
                   
                   
                 AAGAGATTCAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTT[C/T]TTCTT 
               
               
                   
                   
                   
                 TGACTGGTACT 
               
               
                   
                   
                   
                 TCCGCCCTA 
               
               
                 787-788 
                 cg43931352 
                  111 
                 GCGTCGTTCCT 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCGGTCCATCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGC[T/C]CATG 
               
               
                   
                   
                   
                 CTCAGGGCGG 
               
               
                   
                   
                   
                 TGGCAAAGGG 
               
               
                   
                   
                   
                 G 
               
               
                 789-790 
                 cg43931759 
                 2018 
                 AGCTGGGATGT 
                 G 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                  6 
               
               
                   
                   
                   
                 ACCTGGAGAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATAG[G/C]GGG 
               
               
                   
                   
                   
                 TAGTTCTCCCT 
               
               
                   
                   
                   
                 ACTGCCCAGG 
               
               
                   
                   
                   
                 C 
               
               
                 791-792 
                 cg43931795 
                 1456 
                 AGAATGGCAG 
                 G 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                  7 
               
               
                   
                   
                   
                 GCGGACCGTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCGAA[G/gap]G 
               
               
                   
                   
                   
                 CTCTGCCCTGG 
               
               
                   
                   
                   
                 TTGAACATTTC 
               
               
                   
                   
                   
                 TG 
               
               
                 793-794 
                 cg43933469 
                  689 
                 TGTGCCAGGT 
                 C 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCCGTCTGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCTGG[C/A]TC 
               
               
                   
                   
                   
                 CATCATGACGC 
               
               
                   
                   
                   
                 GTCACTTTGTC 
               
               
                   
                   
                   
                 C 
               
               
                 795-796 
                 cg43934707 
                  651 
                 CGGTGGGACC 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGCGCCATCAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTCC[G/A]TAC 
               
               
                   
                   
                   
                 GGATGTTCTCC 
               
               
                   
                   
                   
                 CTCCGGAAGC 
               
               
                   
                   
                   
                 C 
               
               
                 797-798 
                 cg43934839 
                 1383 
                 CCAACCATGCA 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 13 
               
               
                   
                   
                   
                 TTAAGTTTAAC 
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CAA[A/G]AGCT 
               
               
                   
                   
                   
                 GCAATATTCCA 
               
               
                   
                   
                   
                 GATTCTTAAA 
               
               
                 799-800 
                 cg43934839 
                 1547 
                 GGTGCCTGTTT 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 13 
               
               
                   
                   
                   
                 ACTTCTGGTCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCG[C/T]GGGC 
               
               
                   
                   
                   
                 TCAGGTTTCAA 
               
               
                   
                   
                   
                 AGAGCTTGCT 
               
               
                 801-802 
                 cg43934938 
                 4214 
                 TGAGGAAACCT 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 16 
               
               
                   
                   
                   
                 AGGAAATCTCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTG[C/T]ACTAG 
               
               
                   
                   
                   
                 GAAGTGAATCC 
               
               
                   
                   
                   
                 CGCAGGACA 
               
               
                 803-804 
                 cg43934938 
                 4231 
                 TCTCGGTGCAC 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 16 
               
               
                   
                   
                   
                 TAGGAAGTGAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCC[C/T]GCAG 
               
               
                   
                   
                   
                 GACAGCTGCA 
               
               
                   
                   
                   
                 CTCAGGGATAC 
               
               
                 805-806 
                 cg43934938 
                 4351 
                 GATTGTCTTTC 
                 A 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 16 
               
               
                   
                   
                   
                 TGCCACAGAAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGC[A/T]GCAG 
               
               
                   
                   
                   
                 ACGTGTCGGG 
               
               
                   
                   
                   
                 AGGTTAGCTGC 
               
               
                 807-808 
                 cg43934938 
                 4391 
                 AGGTTAGCTGC 
                 A 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                 16 
               
               
                   
                   
                   
                 GGAAAGAAATC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGG[A/C]TGCC 
               
               
                   
                   
                   
                 GCGGAGCACA 
               
               
                   
                   
                   
                 GAGTGATTTGG 
               
               
                 809-810 
                 cg43934938 
                 4395 
                 TAGCTGCGGAA 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 16 
               
               
                   
                   
                   
                 AGAAATCGGGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGC[C/T]GCGG 
               
               
                   
                   
                   
                 AGCACAGAGT 
               
               
                   
                   
                   
                 GATTTGGAACT 
               
               
                 811-812 
                 cg43935748 
                 1437 
                 ATGCTATGGGT 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 14 
               
               
                   
                   
                   
                 ATCTGTTTCAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAG[C/T]TCTGT 
               
               
                   
                   
                   
                 TGGTATCTTGT 
               
               
                   
                   
                   
                 GGTGTCTGC 
               
               
                 813-814 
                 cg43935826 
                  266 
                 TCATTACGGTC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACAATGACGAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTC[A/G]GAAA 
               
               
                   
                   
                   
                 CCATGCAATGA 
               
               
                   
                   
                   
                 AACCAATAAA 
               
               
                 815-816 
                 cg43936051 
                  705 
                 TCAGAAAAAAA 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                  4 
               
               
                   
                   
                   
                 GCTATCCAGCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTT[C/T]GTGGA 
               
               
                   
                   
                   
                 ATCTGGTGAAG 
               
               
                   
                   
                   
                 TTTACACTT 
               
               
                 817-818 
                 cg43939976 
                 1317 
                 CCGTCGGTCCT 
                 C 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                  6 
               
               
                   
                   
                   
                 GGCGTAGCGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTCC[C/gap]GT 
               
               
                   
                   
                   
                 GTCCGGGGTA 
               
               
                   
                   
                   
                 GATCTTGTACC 
               
               
                   
                   
                   
                 CG 
               
               
                 819-820 
                 cg43941070 
                 1254 
                 ATGTTCCCCGG 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 CCTGCGACCAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAC[G/A]CTTTT 
               
               
                   
                   
                   
                 TCCTGACTACT 
               
               
                   
                   
                   
                 TCTTCAACT 
               
               
                 821-822 
                 cg43941070 
                 1278 
                 CGCTTTTTCCT 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 GACTACTTCTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CM[C/T]TCTGA 
               
               
                   
                   
                   
                 CATAGGTTTTG 
               
               
                   
                   
                   
                 CTGATATAA 
               
               
                 823-824 
                 cg43941070 
                 1284 
                 TTCCTGACTAC 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 TTCTTCAACTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGA[C/T]ATAGG 
               
               
                   
                   
                   
                 TTTTGCTGATA 
               
               
                   
                   
                   
                 TAAACGCAA 
               
               
                 825-826 
                 cg43941070 
                 1305 
                 CTGACATAGGT 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 TTTGCTGATAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAA[C/T]GCAAA 
               
               
                   
                   
                   
                 CCCGGCTCTAT 
               
               
                   
                   
                   
                 ACCTACCAA 
               
               
                 827-828 
                 cg43942215 
                 5435 
                 AGCCAATATAG 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 12 
               
               
                   
                   
                   
                 GGCCTCGTCTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACT[C/T]AGGTG 
               
               
                   
                   
                   
                 TCAGTGCTGCA 
               
               
                   
                   
                   
                 GTATGGAAG 
               
               
                 829-830 
                 cg43942920 
                 1632 
                 TGCGTGGTGA 
                 T 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 X 
               
               
                   
                   
                   
                 CGGGCAGTGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGACA[T/G]GT 
               
               
                   
                   
                   
                 GCGTGCACTTC 
               
               
                   
                   
                   
                 TTTTGATGTGGA 
               
               
                   
                   
                   
                 G 
               
               
                 831-832 
                 cg43942990 
                  826 
                 GGCTGTAGAAT 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                  1 
               
               
                   
                   
                   
                 ACCTTCTCCTT 
                   
                   
                   
                   
                 NONCODING 
                   
                   
                   
                 (1p11) 
               
               
                   
                   
                   
                 GAC[G/A]GGGT 
               
               
                   
                   
                   
                 ACAGCAGCTCC 
               
               
                   
                   
                   
                 ACATCCCTCT 
               
               
                 833-834 
                 cg43943163 
                  881 
                 CTGAGCTATAA 
                 T 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                  1 
               
               
                   
                   
                   
                 ACTTGTCATAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATT[T/C]GCTGT 
               
               
                   
                   
                   
                 GTCATCGCAG 
               
               
                   
                   
                   
                 GCTGCAACTG 
               
               
                 835-836 
                 cg43944408 
                 1076 
                 AGGAGGCAAT 
                 gap 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 GAGATGATGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGTGA[gap/G]G 
               
               
                   
                   
                   
                 GAAACATGAAA 
               
               
                   
                   
                   
                 GTAACACTTGA 
               
               
                   
                   
                   
                 TT 
               
               
                 837-838 
                 cg43944446 
                  906 
                 ACTCTGATCGG 
                 T 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                 16 
               
               
                   
                   
                   
                 TTATTATCCCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCA]T/gap]TTTT 
               
               
                   
                   
                   
                 TGTAGGAAATA 
               
               
                   
                   
                   
                 AGTTTGCTTG 
               
               
                 839-840 
                 cg43946473 
                  880 
                 CACAGAAAAGA 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 11 
               
               
                   
                   
                   
                 CAACAGATGTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTT[C/T]TAAGG 
               
               
                   
                   
                   
                 CACGATTTACA 
               
               
                   
                   
                   
                 TACTAAATT 
               
               
                 841-842 
                 cg43946992 
                  136 
                 ACATCTGGGTT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GACCAGGAGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CACA[A/G]AAGT 
               
               
                   
                   
                   
                 TCCCATCATGA 
               
               
                   
                   
                   
                 GAAAGGGGGC 
               
               
                 843-844 
                 cg43947759 
                  876 
                 TCAACTTCTGT 
                 gap 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 22 
               
               
                   
                   
                   
                 AAGATGGGGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGGG[gap/G]A 
               
               
                   
                   
                   
                 CAAAAAGAGAA 
               
               
                   
                   
                   
                 GTAAAGTTAAG 
               
               
                   
                   
                   
                 AA 
               
               
                 845-846 
                 cg43948617 
                 1024 
                 AGAGGTTATCA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGGACATTTAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGA[A/G]TCCT 
               
               
                   
                   
                   
                 GATCCTCAGAA 
               
               
                   
                   
                   
                 CTTCTCTGGG 
               
               
                 847-848 
                 cg43949585 
                 1172 
                 GTAATGTTAAA 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                  8 
               
               
                   
                   
                   
                 ACTAAATACAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATG[A/G]TAATA 
               
               
                   
                   
                   
                 ATTGCTATTTC 
               
               
                   
                   
                   
                 ACAGTGATG 
               
               
                 849-850 
                 cg43949806 
                  460 
                 TTACCAACCCT 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 16 
               
               
                   
                   
                   
                 GGGGCTTTATA 
                   
                   
                   
                   
                 NONCODING 
                   
                   
                   
                 (16p13.1) 
               
               
                   
                   
                   
                 CTC[C/T]CTCTC 
               
               
                   
                   
                   
                 CACCAATCCCT 
               
               
                   
                   
                   
                 GATGACCCC 
               
               
                 851-852 
                 cg43950348 
                 1308 
                 GGCATTGCAG 
                 A 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                  9 
               
               
                   
                   
                   
                 CGGCTCGGGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCCAA[A/C]GC 
               
               
                   
                   
                   
                 CTCACTACCAG 
               
               
                   
                   
                   
                 TCTGGGTCCG 
               
               
                   
                   
                   
                 GC 
               
               
                 853-854 
                 cg43950620 
                  262 
                 AGCAAGGAATG 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                  8 
               
               
                   
                   
                   
                 TTCTTATTCTTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GT[A/G]GGAGC 
               
               
                   
                   
                   
                 TCCTTCTTTAC 
               
               
                   
                   
                   
                 ACTGTCAGG 
               
               
                 855-856 
                 cg43951104 
                  679 
                 TAGTGAAAACC 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 AAGTGACAAAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACA[C/T]TCCTC 
               
               
                   
                   
                   
                 GACCCCAAGTT 
               
               
                   
                   
                   
                 CTTCCACAT 
               
               
                 857-858 
                 cg43951505 
                  603 
                 AAAGGTGGAAA 
                 A 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATGAGGTTGAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGC[A/C]GCAT 
               
               
                   
                   
                   
                 TCAGAAAGTGT 
               
               
                   
                   
                   
                 ATAAGACCTA 
               
               
                 859-860 
                 cg43952456 
                  394 
                 AATGCTAAACT 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCTTTCATGCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAT[T/C]TTCTG 
               
               
                   
                   
                   
                 ACTGTTTACTT 
               
               
                   
                   
                   
                 ACCGGGTAA 
               
               
                 861-862 
                 cg43952456 
                  401 
                 AACTGCTTTCA 
                 C 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGCTAATTTTCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GA[C/A]TGTTTA 
               
               
                   
                   
                   
                 CTTACCGGGTA 
               
               
                   
                   
                   
                 AGAGCGAT 
               
               
                 863-864 
                 cg43952456 
                  416 
                 AATTTTCTGAC 
                 G 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGTTTACTTAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGG[G/C]TAAG 
               
               
                   
                   
                   
                 AGCGATGGGA 
               
               
                   
                   
                   
                 CTGTTTTCATT 
               
               
                 865-866 
                 cg43953844 
                 1867 
                 CTCAACCTGCC 
                 T 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                  7 
               
               
                   
                   
                   
                 TTAGCTGCACT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTC[T/C]TACCT 
               
               
                   
                   
                   
                 ACAGCTGGACA 
               
               
                   
                   
                   
                 GTACCTGTC 
               
               
                 867-868 
                 cg43955665 
                  184 
                 CTGCCAGCTGA 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                 16 
               
               
                   
                   
                   
                 CAGGATCTTTT 
                   
                   
                   
                   
                 NONCODING 
                   
                   
                   
                 (16q22) 
               
               
                   
                   
                   
                 GCT[G/A]GGCC 
               
               
                   
                   
                   
                 CCCTTCTCTGT 
               
               
                   
                   
                   
                 GCTGAGTGGA 
               
               
                 869-870 
                 cg43955829 
                  593 
                 ATAAGGCCATT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CAGCGAGGGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCAT[C/T]AAGT 
               
               
                   
                   
                   
                 GCAACTTTGCG 
               
               
                   
                   
                   
                 GGGGTTGCCT 
               
               
                 871-872 
                 cg43955863 
                  290 
                 AGGACACCAA 
                 T 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                  7 
               
               
                   
                   
                   
                 GGTACCCAATG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCTG[G/C]TTAT 
               
               
                   
                   
                   
                 TCACCATCAAC 
               
               
                   
                   
                   
                 AAAGAAGACC 
               
               
                 873-874 
                 cg43955871 
                 1011 
                 AGCGCTCCTCC 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                  7 
               
               
                   
                   
                   
                 AGCAGGGACA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCTC[A/G]CTG 
               
               
                   
                   
                   
                 ATGAGGTCGGT 
               
               
                   
                   
                   
                 GATGGCGTTG 
               
               
                   
                   
                   
                 G 
               
               
                 875-876 
                 cg43957194 
                  591 
                 CCATTTTTAGC 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                 — 
               
               
                   
                   
                   
                 ATCAGAAACAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAG]G/A]AAATA 
               
               
                   
                   
                   
                 AAATTCGTGGT 
               
               
                   
                   
                   
                 TAGATTGAT 
               
               
                 877-878 
                 c943957205 
                  782 
                 ATACCTGAGGT 
                 T 
                 C 
                   
                   
                 SILENT- 
                 13 
                 j 
               
               
                   
                   
                   
                 TTCATGTCTTTA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GT[T/C]GCCTTA 
               
               
                   
                   
                   
                 TCATAATCCCA 
               
               
                   
                   
                   
                 AATATACA 
               
               
                 879-880 
                 cg43958108 
                  777 
                 CAGCAAACCTG 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                  5 
               
               
                   
                   
                   
                 AATGGCACAAT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGA[A/G]CACA 
               
               
                   
                   
                   
                 GACTTAAAAGA 
               
               
                   
                   
                   
                 TGCTTCAGTG 
               
               
                 881-882 
                 cg43959150 
                  709 
                 ACTTCCACGCG 
                 C 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                 22 
               
               
                   
                   
                   
                 GTGAACGTGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGCA[C/gap]CC 
               
               
                   
                   
                   
                 GTTCGCTTCAG 
               
               
                   
                   
                   
                 CAGTTTCCTAG 
               
               
                   
                   
                   
                 G 
               
               
                 883-884 
                 cg43959363 
                  614 
                 CTTCATTTCTTT 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 GGTTTCTTGGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TA[G/A]TGGGC 
               
               
                   
                   
                   
                 GCCGGAACAG 
               
               
                   
                   
                   
                 CAAGATGTGA 
               
               
                 885-886 
                 cg43960242 
                  16 
                 ACTGCAACGC 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 19 
               
               
                   
                   
                   
                 GGAGG[A/G]GC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGGATGGAGAT 
               
               
                   
                   
                   
                 CCCTGTGCCTG 
               
               
                   
                   
                   
                 T 
               
               
                 887-888 
                 cg43960953 
                 2143 
                 AACAGTGGGC 
                 C 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATGTCTTCTCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGGT[C/A]GAT 
               
               
                   
                   
                   
                 CGGTTTCTCTG 
               
               
                   
                   
                   
                 GCTCCTTCTTA 
               
               
                 889-890 
                 cg43962392 
                  910 
                 AAAGAAGGTAG 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                  1 
               
               
                   
                   
                   
                 AGGAACTTGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAGA[C/T]TGA 
               
               
                   
                   
                   
                 GGGAAAGATA 
               
               
                   
                   
                   
                 GGAGAGAGGA 
               
               
                   
                   
                   
                 AG 
               
               
                 891-892 
                 cg43964611 
                  319 
                 GCTGGGCTTC 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCCGAGCTGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGAGC[G/A]GG 
               
               
                   
                   
                   
                 GAGGACCAGC 
               
               
                   
                   
                   
                 CCTTCTCCAGG 
               
               
                   
                   
                   
                 CT 
               
               
                 893-894 
                 cg43965993 
                 2007 
                 GTCGTTTTCTC 
                 T 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                  4 
               
               
                   
                   
                   
                 AAAAAAATATC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTA[T/C]AAGTG 
               
               
                   
                   
                   
                 ACTCATCCTGT 
               
               
                   
                   
                   
                 CTGCTAACT 
               
               
                 895-896 
                 cg43966536 
                  659 
                 CCCAGTATGTA 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                  7 
               
               
                   
                   
                   
                 CCACCCCGTTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTC[G/A]TAAAT 
               
               
                   
                   
                   
                 GAAGGCAGCA 
               
               
                   
                   
                   
                 GCTCCAGCCA 
               
               
                 897-898 
                 cg43967276 
                  314 
                 CACGTGCGTG 
                 T 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                  9 
               
               
                   
                   
                   
                 GGGTGTTGGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATTCT[T/C]GTT 
               
               
                   
                   
                   
                 ATTTAACACGG 
               
               
                   
                   
                   
                 GAAGGAGGTG 
               
               
                   
                   
                   
                 A 
               
               
                 899-900 
                 cg43967511 
                  276 
                 TAGTCCTGTTG 
                 G 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                 12 
               
               
                   
                   
                   
                 ACCTGGAAATG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTG[G/C]CAGG 
               
               
                   
                   
                   
                 TGAAGTCTCTC 
               
               
                   
                   
                   
                 CACAGCATGC 
               
               
                 901-902 
                 cg43968814 
                 3546 
                 GCCAGAGCTTC 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 CGCGCCCTCG 
                   
                   
                   
                   
                 NONCODING 
                   
                   
                   
                 (17q22) 
               
               
                   
                   
                   
                 CCTG[C/T]CCA 
               
               
                   
                   
                   
                 GGTGTCCTGCT 
               
               
                   
                   
                   
                 CGCCTCCATCT 
               
               
                 903-904 
                 cg43969044 
                  734 
                 CCTCTGATGTT 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                  5 
               
               
                   
                   
                   
                 CAGTGAAGAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GACC[A/G]GAA 
               
               
                   
                   
                   
                 AAGTCTGCTAG 
               
               
                   
                   
                   
                 AGCAGTACCAT 
               
               
                 905-906 
                 cg43970408 
                  949 
                 CTCTTTGGCTT 
                 G 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 GTTTTGGCGCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGC[G/gap]CTG 
               
               
                   
                   
                   
                 GCAGAGGCTG 
               
               
                   
                   
                   
                 AGACACGGCG 
               
               
                   
                   
                   
                 AG 
               
               
                 907-908 
                 cg43970722 
                  769 
                 CCACCATCTCC 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTTGTTTCTGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAG[C/T]ACCCT 
               
               
                   
                   
                   
                 CCAGGCAGGC 
               
               
                   
                   
                   
                 CAGCCAGCAT 
               
               
                 909-910 
                 cg43971702 
                  705 
                 CTCAGCTCCTC 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 20 
               
               
                   
                   
                   
                 CAAATGGTTGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCA[C/T]CCCA 
               
               
                   
                   
                   
                 GACGACTGGG 
               
               
                   
                   
                   
                 GGGTTGGTGG 
               
               
                   
                   
                   
                 A 
               
               
                 911-912 
                 cg43971764 
                 4293 
                 CCTCAGCCTCC 
                 T 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                 15 
               
               
                   
                   
                   
                 CAAAGTGCTGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAT[T/C]ACAG 
               
               
                   
                   
                   
                 GCATGAGCCA 
               
               
                   
                   
                   
                 CCACGCCCGG 
               
               
                   
                   
                   
                 C 
               
               
                 913-914 
                 cg43972482 
                  412 
                 TTAGTAGAGAC 
                 T 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                  8 
               
               
                   
                   
                   
                 GGGGTTTCACC 
                 NONCODING 
               
               
                   
                   
                   
                 ATG[T/C]TGGTC 
               
               
                   
                   
                   
                 AGGCTGGTCTC 
               
               
                   
                   
                   
                 GAACTCCTG 
               
               
                 915-916 
                 cg43973408 
                  205 
                 ACCGAGGAGC 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 19 
               
               
                   
                   
                   
                 AGGAATATGAG 
                   
                   
                   
                   
                 NONCODING 
                   
                   
                   
                 (19q13.4) 
               
               
                   
                   
                   
                 GAGG[A/G]GCA 
               
               
                   
                   
                   
                 GCCGGAAGAG 
               
               
                   
                   
                   
                 GAGGCTGCGG 
               
               
                   
                   
                   
                 AG 
               
               
                 917-918 
                 cg43974489 
                  666 
                 GGCTAGCCCA 
                 T 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                  1 
               
               
                   
                   
                   
                 CCTGCCATGGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGCC[T/C]TTCT 
               
               
                   
                   
                   
                 GCTTGGGGAT 
               
               
                   
                   
                   
                 GCCCTGTCT 
               
               
                   
                   
                   
                 G 
               
               
                 919-920 
                 cg43974987 
                 1386 
                 CATCCTCAGAG 
                 C 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                 22 
               
               
                   
                   
                   
                 TCTGAGCGGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACCG[C/gap]AG 
               
               
                   
                   
                   
                 ACCTTCTTTTTC 
               
               
                   
                   
                   
                 AAGTTCACTAA 
               
               
                 921-922 
                 cg43977577 
                  590 
                 CGTAGTGTAAA 
                 G 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GAACGTAAATT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAA[G/gap]GCC 
               
               
                   
                   
                   
                 CCGGGCCAATT 
               
               
                   
                   
                   
                 CTGGGAAGA 
               
               
                   
                   
                   
                 G 
               
               
                 923-924 
                 cg43977577 
                  591 
                 GTAGTGTAAAG 
                 G 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AACGTAAATTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAG[G/gap]CCC 
               
               
                   
                   
                   
                 CGGGCCAATTC 
               
               
                   
                   
                   
                 TGGGAAGAGG 
               
               
                   
                   
                   
                 A 
               
               
                 925-926 
                 cg43977954 
                 2556 
                 TGTGAACGGC 
                 T 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCGGAGAGAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTGGG[T/A]GG 
               
               
                   
                   
                   
                 TGTATGGGGTG 
               
               
                   
                   
                   
                 ACCTCCTGGG 
               
               
                   
                   
                   
                 GG 
               
               
                 927-928 
                 cg43979039 
                  674 
                 CGCCCCTCACA 
                 C 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                  2 
               
               
                   
                   
                   
                 GTGAAGAATCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGA[C/G]AGCC 
               
               
                   
                   
                   
                 ACTCTCTGGTT 
               
               
                   
                   
                   
                 TTCTCACAAC 
               
               
                 929-930 
                 cg43979039 
                  769 
                 GTCCTGGTCCC 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                  2 
               
               
                   
                   
                   
                 ACACAGAGAGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGA[A/G]GCGC 
               
               
                   
                   
                   
                 CACAACCCACT 
               
               
                   
                   
                   
                 CTGCCAACCT 
               
               
                 931-932 
                 cg43980463 
                  970 
                 AGAAGCTGGCT 
                 G 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                 16 
               
               
                   
                   
                   
                 GGTAGGACCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCAG[G/gap]GA 
               
               
                   
                   
                   
                 CCAGCTGACCA 
               
               
                   
                   
                   
                 GGCTTGTGCTC 
               
               
                   
                   
                   
                 A 
               
               
                 933-934 
                 cg43980508 
                  349 
                 TTCTTGCAATT 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                  5 
               
               
                   
                   
                   
                 ATCCAGGCAG 
                   
                   
                   
                   
                 NONCODING 
                   
                   
                   
                 (5q13.3) 
               
               
                   
                   
                   
                 GTGA[C/T]GAC 
               
               
                   
                   
                   
                 AACTTGATGCA 
               
               
                   
                   
                   
                 GGAAATCAACC 
               
               
                 935-936 
                 cg43980653 
                 1001 
                 CCCCCTCAGC 
                 C 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                 18 
               
               
                   
                   
                   
                 CATTGCCCATG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGGG[C/gap]CT 
               
               
                   
                   
                   
                 CCACGTTGTCT 
               
               
                   
                   
                   
                 GATGGTCGCT 
               
               
                   
                   
                   
                 GG 
               
               
                 937-938 
                 cg43981661 
                  577 
                 TCATGAGCCCG 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 CTGACCCGGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGGC[C/T]GAG 
               
               
                   
                   
                   
                 GGCAGGTAGG 
               
               
                   
                   
                   
                 GAGACTTCCTC 
               
               
                   
                   
                   
                 G 
               
               
                 939-940 
                 cg43982025 
                  488 
                 TGGGAAGGCG 
                 G 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                 19 
               
               
                   
                   
                   
                 CATATCCTGGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGCA[G/gap]CA 
               
               
                   
                   
                   
                 GCACGTGGCA 
               
               
                   
                   
                   
                 CCAGGTGCCA 
               
               
                   
                   
                   
                 GGC 
               
               
                 941-942 
                 cg43982782 
                 1142 
                 GGTCCCTGCC 
                 G 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                  4 
               
               
                   
                   
                   
                 ACAGCCGTGG 
                   
                   
                   
                   
                 NONCODING 
                   
                   
                   
                 (4p16.3) 
               
               
                   
                   
                   
                 AGGGC[G/C]GA 
               
               
                   
                   
                   
                 CGTGACCTACG 
               
               
                   
                   
                   
                 CGGCCATGGT 
               
               
                   
                   
                   
                 GG 
               
               
                 943-944 
                 cg43983035 
                 1104 
                 CAGGCGGACC 
                 T 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                  5 
               
               
                   
                   
                   
                 TGGAGGTGTCA 
                   
                   
                   
                   
                 NONCODING 
                   
                   
                   
                 (5q31.3) 
               
               
                   
                   
                   
                 GCCA[T/C]GGC 
               
               
                   
                   
                   
                 CCTGACCACTT 
               
               
                   
                   
                   
                 CAGAAGCCAAC 
               
               
                 945-946 
                 cg43983194 
                  196 
                 GGCCAACCAT 
                 T 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 GAGGAGTGCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAGGG[T/C]GG 
               
               
                   
                   
                   
                 CACCGGCCAG 
               
               
                   
                   
                   
                 TGCCCCTGGA 
               
               
                   
                   
                   
                 CAC 
               
               
                 947-948 
                 cg43983194 
                  451 
                 GCAGCCATGC 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 GCACCTCCAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCACG[G/A]CC 
               
               
                   
                   
                   
                 GAGCTCAACCC 
               
               
                   
                   
                   
                 GAAGACCACG 
               
               
                   
                   
                   
                 CG 
               
               
                 949-950 
                 cg43983314 
                  730 
                 CAAATGGCAAC 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATAATGAAATC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACT[T/C]TCTGC 
               
               
                   
                   
                   
                 ATCCAGAATTA 
               
               
                   
                   
                   
                 CACCCCCAA 
               
               
                 951-952 
                 cg43983314 
                  733 
                 ATGGCAACATA 
                 T 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATGAAATCACT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTC[T/A]GCATC 
               
               
                   
                   
                   
                 CAGAATTACAC 
               
               
                   
                   
                   
                 CCCCAAGGT 
               
               
                 953-954 
                 cg43983314 
                  856 
                 CCGCGAGGTG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCCTATGCCTA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CATC[C/T]GTGA 
               
               
                   
                   
                   
                 GGGCCATGAG 
               
               
                   
                   
                   
                 AAGCAGGCCG 
               
               
                   
                   
                   
                 A 
               
               
                 955-956 
                 cg43984242 
                  307 
                 AGCTCATCCAG 
                 C 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTGGACCAGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGAA[C/gap]CC 
               
               
                   
                   
                   
                 CTGGCCGCTG 
               
               
                   
                   
                   
                 TGCTGAAGGA 
               
               
                   
                   
                   
                 GGT 
               
               
                 957-958 
                 cg43986540 
                 1009 
                 GACACCGCCT 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCCTGGTGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCCAG[G/A]GG 
               
               
                   
                   
                   
                 TGAAGCAGGC 
               
               
                   
                   
                   
                 CAGAATCCTGG 
               
               
                   
                   
                   
                 GG 
               
               
                 959-960 
                 cg43987682 
                 1309 
                 AGCCCTTCTCC 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 AGCACCTTGGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAA[A/G]ATGTC 
               
               
                   
                   
                   
                 CGTCAGCACCT 
               
               
                   
                   
                   
                 CTTTGATGG 
               
               
                 961-962 
                 cg43991793 
                  915 
                 CCCCTGTGCCA 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                  9 
               
               
                   
                   
                   
                 TCATTTGGGCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCC[C/T]AGAC 
               
               
                   
                   
                   
                 ACTGGAGGAC 
               
               
                   
                   
                   
                 AGCGTGAGATA 
               
               
                 963-964 
                 cg43991835 
                  194 
                 AAAAGCGGCG 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 19 
               
               
                   
                   
                   
                 AGGAACGCTTG 
                   
                   
                   
                   
                 NONCODING 
                   
                   
                   
                 (19q13.1) 
               
               
                   
                   
                   
                 AAGG[A/G]AAT 
               
               
                   
                   
                   
                 GGAGGCGGAG 
               
               
                   
                   
                   
                 ATGGCCCTGTT 
               
               
                   
                   
                   
                 T 
               
               
                 965-966 
                 cg43994222 
                  230 
                 CACAGAGATTT 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                 18 
               
               
                   
                   
                   
                 TACATCACCTT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCA[G/A]AACG 
               
               
                   
                   
                   
                 CAACAGGGTC 
               
               
                   
                   
                   
                 CGGGACAGGG 
               
               
                   
                   
                   
                 A 
               
               
                 967-968 
                 cg43995297 
                  288 
                 AGGATCCCTG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCTCGCGTCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCAAC[C/T]GG 
               
               
                   
                   
                   
                 TTCCGTGTCTC 
               
               
                   
                   
                   
                 ACCTGGGTCCT 
               
               
                   
                   
                   
                 G 
               
               
                 969-970 
                 cg43995517 
                  460 
                 TGGCCGTAGG 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 12 
               
               
                   
                   
                   
                 AGAAAATACAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCCT[A/G]CCC 
               
               
                   
                   
                   
                 GGAACAGCAAT 
               
               
                   
                   
                   
                 AGCTCCCGCC 
               
               
                   
                   
                   
                 A 
               
               
                 971-972 
                 cg43995517 
                  516 
                 TTACCTTGGAA 
                 C 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 12 
               
               
                   
                   
                   
                 CCCAGCCCTAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGC[C/G]CGAG 
               
               
                   
                   
                   
                 CAGCTGTCCCT 
               
               
                   
                   
                   
                 CTGCCTCCCC 
               
               
                 973-974 
                 cg43995517 
                  532 
                 CCCTACAGCCC 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 12 
               
               
                   
                   
                   
                 GAGCAGCTGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCCT[C/T]TGCC 
               
               
                   
                   
                   
                 TCCCCGGGCC 
               
               
                   
                   
                   
                 CGCCCTGGCC 
               
               
                   
                   
                   
                 G 
               
               
                 975-976 
                 cg43997174 
                  735 
                 GGTCATCACAC 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                  1 
               
               
                   
                   
                   
                 ACAAGTGGACC 
                   
                   
                   
                   
                 NONCODING 
                   
                   
                   
                 (1p13.1) 
               
               
                   
                   
                   
                 ACC[A/G]GCCT 
               
               
                   
                   
                   
                 GAGTGCAAAAT 
               
               
                   
                   
                   
                 TCAAGTGCAC 
               
               
                 977-978 
                 cg43997490 
                  511 
                 AACATGAGGAC 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                  1 
               
               
                   
                   
                   
                 CCTCTGGATTA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATC[G/A]AATTA 
               
               
                   
                   
                   
                 CAGCTGCTAGC 
               
               
                   
                   
                   
                 CAGGAACAT 
               
               
                 979-980 
                 cg43997710 
                  242 
                 ATGTGAGGTGT 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GACCTCACGAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAA[G/A]CAAAT 
               
               
                   
                   
                   
                 TTAATATTATAA 
               
               
                   
                   
                   
                 TGGGAAGC 
               
               
                 981-982 
                 cg43997768 
                  261 
                 AGATCCCAAAG 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                  8 
               
               
                   
                   
                   
                 CCCAGTACACA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGT[A/G]TCTAC 
               
               
                   
                   
                   
                 GGAGCCCTCA 
               
               
                   
                   
                   
                 AGAAAATCAT 
               
               
                 983-984 
                 cg43999766 
                  367 
                 CATGTGAAGAG 
                 gap 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 ACCCAGCCTCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCA[gap/T]AGG 
               
               
                   
                   
                   
                 GTATCCAAGAT 
               
               
                   
                   
                   
                 AAACTTCCGTT 
               
               
                 985-986 
                 cg44000102 
                  879 
                 CTTATTCTTCTT 
                 T 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                 X 
               
               
                   
                   
                   
                 TGAATACAATG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AC[T/gap]TCTG 
               
               
                   
                   
                   
                 GCACTGATCG 
               
               
                   
                   
                   
                 GGTCAGTTTCT 
               
               
                 987-988 
                 cg44000102 
                  880 
                 TTATTCTTCTTT 
                 T 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                 X 
               
               
                   
                   
                   
                 GAATACAATGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CT[T/gap]CTGG 
               
               
                   
                   
                   
                 CACTGATCGG 
               
               
                   
                   
                   
                 GTCAGTTTCTT 
               
               
                 989-990 
                 cg44000102 
                  882 
                 ATTCTTCTTTGA 
                 T 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                 X 
               
               
                   
                   
                   
                 ATACAATGACT 
                 NONCODING 
               
               
                   
                   
                   
                 TC[T/gap]GGCA 
               
               
                   
                   
                   
                 CTGATCGGGTC 
               
               
                   
                   
                   
                 AGTTTCTTCC 
               
               
                 991-992 
                 cg44000241 
                  412 
                 CTCCCTCACGG 
                 gap 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGCCAGCGGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGGG[gap/T]AA 
               
               
                   
                   
                   
                 TGCAGACATCA 
               
               
                   
                   
                   
                 GAACGTGAGG 
               
               
                   
                   
                   
                 GG 
               
               
                 993-994 
                 cg44001933 
                  566 
                 CTCCGCGCAC 
                 C 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGTGGTGGCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACCGC[C/G]AC 
               
               
                   
                   
                   
                 TGGTGCTGAAG 
               
               
                   
                   
                   
                 TGTCGGCGTGT 
               
               
                 995-996 
                 cg44002491 
                  17 
                 GCGCGCCCTT 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTTCCC[T/C]TA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTGCGAGGAG 
               
               
                   
                   
                   
                 CCACCGCCTCT 
               
               
                   
                   
                   
                 TT 
               
               
                 997-998 
                 cg44003839 
                  280 
                 CCCCATCACCA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCGGTTCTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCCG[A/G]TCT 
               
               
                   
                   
                   
                 CCAGCGACAG 
               
               
                   
                   
                   
                 CCCCAGGGCT 
               
               
                   
                   
                   
                 CC 
               
               
                 999-1000 
                 cg44003987 
                 1374 
                 CACACGCACAC 
                 A 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTACATTCACT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACA[A/C]ACGT 
               
               
                   
                   
                   
                 GCAGCCTCCT 
               
               
                   
                   
                   
                 GCACACGTGC 
               
               
                   
                   
                   
                 A 
               
               
                 1001-1002 
                 cg44005542 
                  627 
                 TCCTAATCCCA 
                 G 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGCCAGAACC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAAG[G/gap]CT 
               
               
                   
                   
                   
                 AATGGCCACAT 
               
               
                   
                   
                   
                 TCTTCTTTTAAA 
               
               
                 1003-1004 
                 cg44007769 
                 1257 
                 GGGTCTGCTG 
                 A 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGTTGGAGGA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTGCA[A/T]TGT 
               
               
                   
                   
                   
                 CGCCCTGGGA 
               
               
                   
                   
                   
                 GCCCTCCTGG 
               
               
                   
                   
                   
                 AG 
               
               
                 1005-1006 
                 cg44009153 
                  928 
                 AGCCATGGGTT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGGGTAATAAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAG[A/G]GAGA 
               
               
                   
                   
                   
                 GCATTTGGGGT 
               
               
                   
                   
                   
                 TCAAGAGAGG 
               
               
                 1007-1008 
                 cg44009645 
                 5337 
                 CTTTTCCATGT 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCTCAATATC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAC[T/C]TTTCC 
               
               
                   
                   
                   
                 CGTCTAATGAT 
               
               
                   
                   
                   
                 GACAAATCT 
               
               
                 1009-1010 
                 cg44012500 
                  579 
                 GGCATCTCATC 
                 G 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                 19 
               
               
                   
                   
                   
                 TTGCTGGGGCT 
                   
                   
                   
                   
                 NONCODING 
                   
                   
                   
                 (19q13.2) 
               
               
                   
                   
                   
                 GTT[G/gap]GGT 
               
               
                   
                   
                   
                 CCCCTGGACCT 
               
               
                   
                   
                   
                 CAAATCCCAAT 
               
               
                 1011-1012 
                 cg44014720 
                  482 
                 CAGAGCCCTGT 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CGTGGCCCTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCCA[T/C]CTCC 
               
               
                   
                   
                   
                 TGCGCCAGGA 
               
               
                   
                   
                   
                 AACACAGGTTC 
               
               
                 1013-1014 
                 cg44020161 
                  854 
                 CTCCAAGAGTT 
                 G 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                 17 
               
               
                   
                   
                   
                 CTGGTCTCCCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGA[G/gap]GG 
               
               
                   
                   
                   
                 GCGGAGTTCC 
               
               
                   
                   
                   
                 CTCCCCAGTCC 
               
               
                   
                   
                   
                 CG 
               
               
                 1015-1016 
                 cg44021014 
                  561 
                 GAGGCACACA 
                 G 
                 A 
                   
                   
                 SILENT 
               
               
                   
                   
                   
                 GACAGATGATG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGCA[G/A]CTCT 
               
               
                   
                   
                   
                 TCTCCTTAAAG 
               
               
                   
                   
                   
                 AAGTCTGTGT 
               
               
                 1017-1018 
                 cg44024536 
                 1149 
                 AGGGTGTGTGT 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                  9 
               
               
                   
                   
                   
                 GTGTGTGTGTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGT[G/A]TGTGT 
               
               
                   
                   
                   
                 GTGTGTGTGCG 
               
               
                   
                   
                   
                 TGTGCG 
               
               
                 1019-1020 
                 cg44024536 
                 1153 
                 TGTGTGTGTGT 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                  9 
               
               
                   
                   
                   
                 GTGTGTGTGTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TGT[G/A]TGTGT 
               
               
                   
                   
                   
                 GTGTGCGTGTG 
               
               
                   
                   
                   
                 CG 
               
               
                 1021-1022 
                 cg44026832 
                  299 
                 TGGCTGCAGA 
                 G 
                 A 
                   
                   
                 SILENT 
                   
                   
                   
                 X 
               
               
                   
                   
                   
                 GGTTGAGCCTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTGA[G/A]CCC 
               
               
                   
                   
                   
                 CTGCTTGGTGA 
               
               
                   
                   
                   
                 CAAGGGACCT 
               
               
                   
                   
                   
                 G 
               
               
                 1023-1024 
                 cg44026832 
                  446 
                 CTTCTGGGCTG 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 X 
               
               
                   
                   
                   
                 TGGCCCTGCTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTG[C/T]TGGCT 
               
               
                   
                   
                   
                 ACTCTCATGGA 
               
               
                   
                   
                   
                 GCAGGGCTT 
               
               
                 1025-1026 
                 cg44029982 
                 1149 
                 GGCTGTAGGG 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GATGTTGGTCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCTG[G/A]AAAA 
               
               
                   
                   
                   
                 AGGCGCTGAG 
               
               
                   
                   
                   
                 GGCTGTCTCGA 
               
               
                 1027-1028 
                 cg44030164 
                  245 
                 GGGTGTAGAC 
                 G 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 14 
               
               
                   
                   
                   
                 GCTGCTGGCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGCCC[G/T]CC 
               
               
                   
                   
                   
                 GCAGCCGAGG 
               
               
                   
                   
                   
                 TTCTCGGCACC 
               
               
                   
                   
                   
                 GC 
               
               
                 1029-1030 
                 cg44031677 
                  249 
                 CAGACCCGAG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GTGCCCAGGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CATTC[C/T]GGA 
               
               
                   
                   
                   
                 GGCAGCCGAG 
               
               
                   
                   
                   
                 GGCAGCAGCT 
               
               
                   
                   
                   
                 CC 
               
               
                 1031-1032 
                 cg44031863 
                  401 
                 GGACTTCTGCT 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                  1 
               
               
                   
                   
                   
                 GCGTCTTCGG 
                 NONCODING 
               
               
                   
                   
                   
                 CCAC[C/T]TCTC 
               
               
                   
                   
                   
                 CTCTTGCCTTT 
               
               
                   
                   
                   
                 TGGTGGACCC 
               
               
                 1033-1034 
                 cg44033624 
                 1409 
                 GAAAAGGGATA 
                 G 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                 10 
               
               
                   
                   
                   
                 CTTTGATAATTA 
                   
                   
                   
                   
                 NONCODING 
                   
                   
                   
                 (7q31) 
               
               
                   
                   
                   
                 AG[G/gap]CCAG 
               
               
                   
                   
                   
                 AGGCCCATTAG 
               
               
                   
                   
                   
                 TTGAGAAAGT 
               
               
                 1035-1036 
                 cg44033878 
                 1552 
                 AAGGAGGGAT 
                 T 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                  1 
               
               
                   
                   
                   
                 ATGTTCCACGT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AACT[T/G]GCTG 
               
               
                   
                   
                   
                 GGACTGTACCC 
               
               
                   
                   
                   
                 AAGAATTAAA 
               
               
                 1037-1038 
                 cg44034830 
                  701 
                 GCAGGAGCCT 
                 G 
                 A 
                   
                   
                 SILENT- 
                   
                   
                   
                  5 
               
               
                   
                   
                   
                 GCAGGAGGCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGAAA[G/A]TC 
               
               
                   
                   
                   
                 AGGCTAGGGA 
               
               
                   
                   
                   
                 TATAGCAGGGA 
               
               
                   
                   
                   
                 TG 
               
               
                 1039-1040 
                 cg44127556 
                  521 
                 TGGCGACGAC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TCTGGAGTGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGGAT[A/G]CG 
               
               
                   
                   
                   
                 GGGGAGGCGG 
               
               
                   
                   
                   
                 ATGTCCCTGGG 
               
               
                   
                   
                   
                 TC 
               
               
                 1041-1042 
                 cg44128344 
                  137 
                 CCCCAGGATTC 
                 T 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                 19 
               
               
                   
                   
                   
                 TGGCCTGCTTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACC[T/C]CTGG 
               
               
                   
                   
                   
                 AGCACCAGGC 
               
               
                   
                   
                   
                 CAGGCGGTGT 
               
               
                   
                   
                   
                 C 
               
               
                 1043-1044 
                 cg44131644 
                  894 
                 TGGCCCCCGA 
                 G 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                 21 
               
               
                   
                   
                   
                 CGAGCTGTACA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGCC[G/C]CAC 
               
               
                   
                   
                   
                 AGCTGGCTGCT 
               
               
                   
                   
                   
                 CCGCGTGGTAT 
               
               
                 1045-1046 
                 cg44911913 
                  967 
                 AGGGCGGCTG 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                 15 
               
               
                   
                   
                   
                 CGGGGCTGCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CCTGG[C/T]CC 
               
               
                   
                   
                   
                 CCCGGCCCCT 
               
               
                   
                   
                   
                 CCTGGGCGCC 
               
               
                   
                   
                   
                 CTC 
               
               
                 1047-1048 
                 cg44911913 
                  992 
                 CCCCCCGGCC 
                 C 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 15 
               
               
                   
                   
                   
                 CCTCCTGGGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCCCT[C/G]GT 
               
               
                   
                   
                   
                 CCCGCTCCTG 
               
               
                   
                   
                   
                 GCCCTGCTCC 
               
               
                   
                   
                   
                 CTG 
               
               
                 1049-1050 
                 cg44912347 
                  853 
                 TCTTTACATTA 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 11 
               
               
                   
                   
                   
                 GAGCCAATTTA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AGA[A/G]GGCG 
               
               
                   
                   
                   
                 CTGGTATGTAT 
               
               
                   
                   
                   
                 GAGCTTTTTG 
               
               
                 1051-1052 
                 cg44913333 
                  159 
                 CTCCCCAGAAT 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 12 
               
               
                   
                   
                   
                 TCCTAGACTGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GTT[A/G]ATAGG 
               
               
                   
                   
                   
                 GTCATATTGTG 
               
               
                   
                   
                   
                 AATGTCTCA 
               
               
                 1053-1054 
                 cg44914547 
                  175 
                 GGTCCCCCTG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTTCTTCCCTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CAGA[C/T]ATG 
               
               
                   
                   
                   
                 GTGGAGCTGC 
               
               
                   
                   
                   
                 TGCTGCTGCAG 
               
               
                   
                   
                   
                 A 
               
               
                 1055-1056 
                 cg44914547 
                  86 
                 GGACCTGCAC 
                 G 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGTGTACAGAC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACAC[G/C]TGTT 
               
               
                   
                   
                   
                 CTCTGGTCCTA 
               
               
                   
                   
                   
                 TAATGCTCTA 
               
               
                 1057-1058 
                 cg44914864 
                  641 
                 GCTCCGATGC 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCGATGCATTC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ATAG[T/C]GTCG 
               
               
                   
                   
                   
                 CCTTTCAGGAA 
               
               
                   
                   
                   
                 AGTTCGGTGT 
               
               
                 1059-1060 
                 cg44915149 
                  857 
                 GGGTCATCGA 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CCCCATTGATG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCAC[C/T]AAG 
               
               
                   
                   
                   
                 AACTTCGTGCA 
               
               
                   
                   
                   
                 CGGGTCTGTTG 
               
               
                 1061-1062 
                 cg44916019 
                  445 
                 CCCCTACCTGG 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                 22 
               
               
                   
                   
                   
                 CCTGGCTGGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CTTC[A/G]CGA 
               
               
                   
                   
                   
                 CCACACTCAAC 
               
               
                   
                   
                   
                 TACTGCGTATG 
               
               
                 1063-1064 
                 cg44916367 
                  200 
                 GGTGCCACCA 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GGCTCTTTTTA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 ACAA[A/G]CAGT 
               
               
                   
                   
                   
                 TCTCACAGAAA 
               
               
                   
                   
                   
                 CTAATCAAGT 
               
               
                 1065-1066 
                 cg44916367 
                  248 
                 AGTGAGAACTC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACTTGTTACCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CAA[A/G]GATG 
               
               
                   
                   
                   
                 GCACCAGGCT 
               
               
                   
                   
                   
                 ATTCATGAAGG 
               
               
                 1067-1068 
                 cg44919480 
                  413 
                 GCCACGAAGT 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GATTGTGTCTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CAGC[A/G]TGT 
               
               
                   
                   
                   
                 GGGCGGAACC 
               
               
                   
                   
                   
                 ACACCTTGGCC 
               
               
                   
                   
                   
                 T 
               
               
                 1069-1070 
                 cg44919480 
                  504 
                 GATGGGGCAG 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CTGGGCCTTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCAAC[C/T]AG 
               
               
                   
                   
                   
                 ACAGACGCTGT 
               
               
                   
                   
                   
                 TCCCAGCCCC 
               
               
                   
                   
                   
                 GC 
               
               
                 1071-1072 
                 cg44919623 
                  302 
                 GCCCGCTGCG 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ATATGTCGTCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTTG[G/A]GAAC 
               
               
                   
                   
                   
                 CTCAGCAGCCA 
               
               
                   
                   
                   
                 GCCGTAAGTC 
               
               
                 1073-1074 
                 cg44919623 
                  307 
                 CTGCGATATGT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CGTCCTTTGGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 AAC[C/T]TCAGC 
               
               
                   
                   
                   
                 AGCCAGCCGT 
               
               
                   
                   
                   
                 AAGTCCTCAC 
               
               
                 1075-1076 
                 cg44920877 
                  23 
                 ACGCGTTCTGC 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GAGGCCATGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 G[G/A]GTCTAT 
               
               
                   
                   
                   
                 GCCCCGCGGC 
               
               
                   
                   
                   
                 CGTTGGCCT 
               
               
                 1077-1078 
                 cg44920877 
                  27 
                 CGCGTTCTGC 
                 T 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GAGGCCATGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGGTC[T/C]AT 
               
               
                   
                   
                   
                 GCCCCGCGGC 
               
               
                   
                   
                   
                 CGTTGGCCTC 
               
               
                   
                   
                   
                 GCC 
               
               
                 1079-1080 
                 cg44920877 
                  45 
                 GCGGGTCTAT 
                 G 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCCCGCGGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CGTTG[G/A]CC 
               
               
                   
                   
                   
                 TCGCCCACACC 
               
               
                   
                   
                   
                 CCCGGCCCCA 
               
               
                   
                   
                   
                 CT 
               
               
                 1081-1082 
                 cg44920877 
                  58 
                 CCGCGGCCGT 
                 C 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 TGGCCTCGCC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CACAC[C/T]CC 
               
               
                   
                   
                   
                 CGGCCCCACT 
               
               
                   
                   
                   
                 GCGGGTGGAG 
               
               
                   
                   
                   
                 AGA 
               
               
                 1083-1084 
                 cg44920877 
                  68 
                 TGGCCTCGCC 
                 A 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CACACCCCCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCCCC[A/G]CT 
               
               
                   
                   
                   
                 GCGGGTGGAG 
               
               
                   
                   
                   
                 AGACGTCGGG 
               
               
                   
                   
                   
                 CCC 
               
               
                 1085-1086 
                 cg44923068 
                  71 
                 CGGACACCCG 
                 G 
                 gap 
                   
                   
                 SILENT- 
                   
                   
                   
                  1 
               
               
                   
                   
                   
                 GCGGGAGCTG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCGGA[G/gap]C 
               
               
                   
                   
                   
                 TCGTGAAGCG 
               
               
                   
                   
                   
                 GAAGCAGGAG 
               
               
                   
                   
                   
                 CTGG 
               
               
                 1087-1088 
                 cg44928274 
                  452 
                 AGCAAGGGGA 
                 G 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 AGATCATCAGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGCA[G/gap]CA 
               
               
                   
                   
                   
                 GCGGCAGCCT 
               
               
                   
                   
                   
                 GCTGTCTTCAG 
               
               
                   
                   
                   
                 GT 
               
               
                 1089-1090 
                 cg44928732 
                  299 
                 GTGTACCAGC 
                 T 
                 G 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 GCCTGATCCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGACA[T/G]TC 
               
               
                   
                   
                   
                 CCTGCCGCAC 
               
               
                   
                   
                   
                 GGTCACGCCT 
               
               
                   
                   
                   
                 GAC 
               
               
                 1091-1092 
                 cg44932136 
                  964 
                 ACAGACGCGC 
                 gap 
                 C 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACACACACGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCACA[gap/C]G 
               
               
                   
                   
                   
                 ACGCACACACA 
               
               
                   
                   
                   
                 GACGCACACA 
               
               
                   
                   
                   
                 CGC 
               
               
                 1093-1094 
                 cg44932136 
                  976 
                 ACACACGCGC 
                 gap 
                 A 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 ACAGACGCACA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CACA[gap/A]GA 
               
               
                   
                   
                   
                 CGCACACACG 
               
               
                   
                   
                   
                 CACAGACACAC 
               
               
                   
                   
                   
                 AC 
               
               
                 1095-1096 
                 cg44932184 
                  644 
                 TGGGCACGAG 
                 G 
                 gap 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CGTGGCTTCG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCGGA[G/gap]C 
               
               
                   
                   
                   
                 AGGATGAACTG 
               
               
                   
                   
                   
                 TCTCAGAGACT 
               
               
                   
                   
                   
                 GG 
               
               
                 1097-1098 
                 cg44938456 
                 2706 
                 TGACCTTGACC 
                 C 
                 T 
                   
                   
                 SILENT- 
                   
                   
                   
                  2 
               
               
                   
                   
                   
                 AGTTTGATCAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTA[C/T]TGCCC 
               
               
                   
                   
                   
                 ACGCTGGAGA 
               
               
                   
                   
                   
                 AGGCAGCACA 
               
               
                 1099-1100 
                 cg44938456 
                 2729 
                 TACTGCCCACG 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                  2 
               
               
                   
                   
                   
                 CTGGAGAAGG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 CAGC[A/G]CAG 
               
               
                   
                   
                   
                 TTGCCAGGCTT 
               
               
                   
                   
                   
                 ATGTGAGACAG 
               
               
                 1101-1102 
                 cg44938456 
                 2738 
                 CGCTGGAGAA 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                  2 
               
               
                   
                   
                   
                 GGCAGCACAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TTGCC[A/G]GG 
               
               
                   
                   
                   
                 CTTATGTGAGA 
               
               
                   
                   
                   
                 CAGACAGGAT 
               
               
                   
                   
                   
                 GG 
               
               
                 1103-1104 
                 cg44938456 
                 2744 
                 AGAAGGCAGC 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                  2 
               
               
                   
                   
                   
                 ACAGTTGCCAG 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCTT[A/G]TGTG 
               
               
                   
                   
                   
                 AGACAGACAG 
               
               
                   
                   
                   
                 GATGGATGGT 
               
               
                 1105-1106 
                 cg44938456 
                 2775 
                 GACAGACAGG 
                 A 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                  2 
               
               
                   
                   
                   
                 ATGGATGGTGC 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GGTC[A/C]CCA 
               
               
                   
                   
                   
                 GTGTAACCATC 
               
               
                   
                   
                   
                 AAATCGGAGAT 
               
               
                 1107-1108 
                 cg44938456 
                 2792 
                 GTGCGGTCAC 
                 A 
                 G 
                   
                   
                 SILENT- 
                   
                   
                   
                  2 
               
               
                   
                   
                   
                 CAGTGTAACCA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 TCAA[A/G]TCG 
               
               
                   
                   
                   
                 GAGATCCTGCC 
               
               
                   
                   
                   
                 AGCTTCACTTC 
               
               
                 1109-1110 
                 cg44938456 
                 2807 
                 TAACCATCAAA 
                 A 
                 C 
                   
                   
                 SILENT- 
                   
                   
                   
                  2 
               
               
                   
                   
                   
                 TCGGAGATCCT 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GCC[A/C]GCTT 
               
               
                   
                   
                   
                 CACTTCAGTCC 
               
               
                   
                   
                   
                 GCCACTGCCA 
               
               
                 1111-1112 
                 cg5633308 
                  186 
                 ACAAGGGGAA 
                 A 
                 T 
                   
                   
                 SILENT- 
               
               
                   
                   
                   
                 CATCAACACAA 
                   
                   
                   
                   
                 NONCODING 
               
               
                   
                   
                   
                 GAGA[A/T]GCC 
               
               
                   
                   
                   
                 TACAAAGGGC 
               
               
                   
                   
                   
                 GAGCGTGCAA 
               
               
                   
                   
                   
                 GC 
               
               
                 1113-1114 
                 cg32160481 
                  124 
                 GAGATGGGGG 
                 C 
                 G 
                 Thr 
                 Ser 
                 CONSERVA- 
                 MHC 
                 Human Gene Similar to SWISSPROT-ID: P30508 
                 5.60E−37 
               
               
                   
                   
                   
                 TCATGGCGCC 
                   
                   
                 (1193) 
                 (1194) 
                 TIVE 
                   
                 HLA CLASS 1 HISTOCOMPATIBILITY 
               
               
                   
                   
                   
                 CCGAA[C/G]CC 
                   
                   
                   
                   
                   
                   
                 ANTIGEN, CW*1201 ALPHA CHAIN 
               
               
                   
                   
                   
                 TCCTCCTGCTG 
                   
                   
                   
                   
                   
                   
                 PRECURSOR (HLA-CX52) -  HOMO SAPIENS   
               
               
                   
                   
                   
                 CTCTCAGGGG 
                   
                   
                   
                   
                   
                   
                 (HUMAN), 366 aa. 
               
               
                   
                   
                   
                 CC 
               
               
                 1115-1116 
                 cg32160481 
                  164 
                 TCTCAGGGGC 
                 G 
                 T 
                 Glu 
                 Asp 
                 CONSERVA- 
                 MHC 
                 Human Gene Similar to SWISSPROT-ID: P30508 
                 5.60E−37 
               
               
                   
                   
                   
                 CCTGGCCCTG 
                   
                   
                 (1195) 
                 (1196) 
                 TIVE 
                   
                 HLA CLASS 1 HISTOCOMPATIBILITY 
               
               
                   
                   
                   
                 ACCGA[G/T]AC 
                   
                   
                   
                   
                   
                   
                 ANTIGEN, CW*1201 ALPHA CHAIN 
               
               
                   
                   
                   
                 CTGGGCGGGT 
                   
                   
                   
                   
                   
                   
                 PRECURSOR (HLA-CX52) -  HOMO SAPIENS   
               
               
                   
                   
                   
                 GAGTGCGGGG 
                   
                   
                   
                   
                   
                   
                 (HUMAN), 366 aa. 
               
               
                   
                   
                   
                 TCG 
               
               
                 1117-1118 
                 cg27790564 
                  65 
                 AGCTTGAGCAG 
                 A 
                 G 
                 Val 
                 Ala 
                 CONSERVA- 
                 protease 
                 Human Gene Similar to SWISSNEW-ID: P53616 
                 9.70E−31 
               
               
                   
                   
                   
                 AGCCTTGACCT 
                   
                   
                 (1197) 
                 (1198) 
                 TIVE 
                   
                 PROTEASOME COMPONENT SUN4 - 
               
               
                   
                   
                   
                 TCT[A/G]CACAC 
                   
                   
                   
                   
                   
                   
                 
                   SACCHAROMYCES CEREVISIAE 
                 
               
               
                   
                   
                   
                 AAACTGTTAGT 
                   
                   
                   
                   
                   
                   
                 (BAKER&#39;S YEAST), 420 aa.| 
               
               
                   
                   
                   
                 GTCGGTGTT 
                   
                   
                   
                   
                   
                   
                 pcls: SWISSPROT-ID: P53616 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 PROTEASOME COMPONENT SUN4 - 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 
                   SACCHAROMYCES CEREVISIAE 
                 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (BAKER&#39;S YEAST), 420 aa. 
               
               
                 1119-1120 
                 cg43967452 
                  418 
                 GCGTTACCGG 
                 G 
                 A 
                 Asp 
                 Asn 
                 CONSERVA- 
                 ribosomalprotrot 
                 Human Gene Similar to SWISSPROT-ID: P32899 
                 2.80E−49 
                 15 
               
               
                   
                   
                   
                 CTGCAGCGGC 
                   
                   
                 (1199) 
                 (1200) 
                 TIVE 
                   
                 PUTATIVE 40S RIBOSOMAL PROTEIN 
               
               
                   
                   
                   
                 GGGAG[G/A]AC 
                   
                   
                   
                   
                   
                   
                 YHR148W -  SACCHAROMYCES CEREVISIAE   
               
               
                   
                   
                   
                 TACACGCGCTA 
                   
                   
                   
                   
                   
                   
                 (BAKER&#39;S YEAST), 183 aa. 
               
               
                   
                   
                   
                 CAACCAGCTGA 
               
               
                 1121-1122 
                 cg39548335 
                  302 
                 TGTATTCTCGT 
                 T 
                 C 
                 Lys 
                 Arg 
                 CONSERVA- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 2.90E−48 
               
               
                   
                   
                   
                 TGTTACCGGCG 
                   
                   
                 (1201) 
                 (1202) 
                 TIVE 
                 FIED 
                   
                 P43618 HYPOTHETICAL 41.3 KD PROTEIN 
               
               
                   
                   
                   
                 GCC[T/C]TCCT 
                   
                   
                   
                   
                   
                   
                   
                 IN SAP155-YMR31 INTERGENIC REGION - 
               
               
                   
                   
                   
                 GGGAGTGCTC 
                   
                   
                   
                   
                   
                   
                   
                   Saccharomyces cerevisiae  (Baker&#39;s yeast), 361 aa. 
               
               
                   
                   
                   
                 ATTATTCATTT 
               
               
                 1123-1124 
                 cg38435145 
                  132 
                 TGCTGGAGAAT 
                 C 
                 T 
                 Ala 
                 Val 
                 CONSERVA- 
                 UNCLASSI- 
                 Human Gene Similar to TREMBLNEW-ACC: 
                 4.10E−46 
               
               
                   
                   
                   
                 TTGGCCACAAA 
                   
                   
                 (1203) 
                 (1204) 
                 TIVE 
                 FIED 
                 BM74914 KIAA0891 PROTEIN -  HOMO SAPIENS   
               
               
                   
                   
                   
                 GAG[C/T]TGCC 
                   
                   
                   
                   
                   
                   
                 (HUMAN), 1371 aa (fragment). 
               
               
                   
                   
                   
                 AAGATAGCTGG 
               
               
                   
                   
                   
                 GCCAGGAAGA 
               
               
                 1125-1126 
                 cg42894694 
                 1008 
                 TTTTGTATTTTT 
                 T 
                 C 
                 Val 
                 Ala 
                 CONSERVA- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 8.30E−34 
               
               
                   
                   
                   
                 AGTAGAGACG 
                   
                   
                 (1205) 
                 (1206) 
                 TIVE 
                 FIED 
                 P39194 !!!! ALU SUBFAMILY SQ WARNING 
               
               
                   
                   
                   
                 GGG[T/C]TTCA 
                   
                   
                   
                   
                   
                   
                 ENTRY -  Homo sapiens  (Human), 593 aa. 
               
               
                   
                   
                   
                 CCATGTTGGCC 
               
               
                   
                   
                   
                 AGGCTGGTCT 
               
               
                 1127-1128 
                 cg27847601 
                  281 
                 TGAGGTGGGA 
                 A 
                 G 
                 Lys 
                 Arg 
                 CONSERVA- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 1.00E−31 
               
               
                   
                   
                   
                 GGACTGCCTG 
                   
                   
                 (1207) 
                 (1208) 
                 TIVE 
                 FIED 
                 P39191 !!!! ALU SUBFAMILY SB2 WARNING 
               
               
                   
                   
                   
                 AACCA[A/G]GG 
                   
                   
                   
                   
                   
                   
                 ENTRY -  Homo sapiens  (Human), 603 aa. 
               
               
                   
                   
                   
                 AGGTGGAGGC 
               
               
                   
                   
                   
                 TGCAGTGAGC 
               
               
                   
                   
                   
                 CAA 
               
               
                 1129-1130 
                 cg43976973 
                 1025 
                 GTGAGCATCAT 
                 C 
                 G 
                 Lys 
                 Asn 
                 NON- 
                 ATPase_asso- 
                 Human Gene Similar to TREMBLNEW-ID: 
                 3.50E−33 
               
               
                   
                   
                   
                 GATGCTGCTGT 
                   
                   
                 (1209) 
                 (1210) 
                 CONSERVA- 
                 ciated 
                 G263099 TAT BINDING PROTEIN 7, TBP- 
               
               
                   
                   
                   
                 CGG[C/G]TTCG 
                   
                   
                   
                   
                 TIVE 
                   
                 7 = TRANSCRIPTIONAL ACTIVATOR - 
               
               
                   
                   
                   
                 GGGGGCAGCA 
                   
                   
                   
                   
                   
                   
                   HOMO SAPIENS , 458 aa. 
               
               
                   
                   
                   
                 CGTCCACCAGT 
               
               
                 1131-1132 
                 cg43925450 
                  848 
                 GCAACTGGTG 
                 G 
                 T 
                 Arg 
                 Leu 
                 NON- 
                 glycoprotein 
                 Human Gene Similar to TREMBLNEW-ID: 
                 3.80E−37 
                 17 
               
               
                   
                   
                   
                 CTCCAGGCCG 
                   
                   
                 (1211) 
                 (1212) 
                 CONSERVA- 
                   
                 E1249608 MEMBRANE-BOUND SMALL GTP- 
               
               
                   
                   
                   
                 AAACC[G/T]AG 
                   
                   
                   
                   
                 TIVE 
                   
                 BINDING - LIKE PROTEIN -  ARABIDOPSIS   
               
               
                   
                   
                   
                 GTGTGGACCTC 
                   
                   
                   
                   
                   
                   
                 THALIANA (MOUSE-EAR CRESS), 217 aa. 
               
               
                   
                   
                   
                 CAGGAGAACAA 
               
               
                   
                   
                   
                 C 
               
               
                 1133-1134 
                 cg43305492 
                  342 
                 CTCCAAAAACC 
                 A 
                 C 
                 Met 
                 Leu 
                 NON- 
                 immunoglob 
                 Human Gene Similar to TREMBLNEW-ID: 
                 7.40E−49 
               
               
                   
                   
                   
                 AGGTGGTCCTT 
                   
                   
                 (1213) 
                 (1214) 
                 CONSERVA- 
                   
                 G2734101 IMMUNOGLOBULIN HEAVY CHAIN, 
               
               
                   
                   
                   
                 ACA[A/C]TGACC 
                   
                   
                   
                   
                 TIVE 
                   
                 VD(5)J(4) LIKE GENE PRODUCT -  HOMO   
               
               
                   
                   
                   
                 AACATGGACCC 
                   
                   
                   
                   
                   
                   
                 SAPIENS (HUMAN), 151 aa. 
               
               
                   
                   
                   
                 TGTGGACAC 
               
               
                 1135-1136 
                 cg34758710 
                  463 
                 GGGCATCATTG 
                 C 
                 T 
                 Leu 
                 Phe 
                 NON- 
                 MHC 
                 Human Gene Similar to SPTREMBL-ID: Q30916 
                 2.20E−39 
               
               
                   
                   
                   
                 CTGGCCTGGTT 
                   
                   
                 (1215) 
                 (1216) 
                 CONSERVA- 
                   
                 MHC CLASS A -  PAN TROGLODYTES   
               
               
                   
                   
                   
                 GTC[C/T]TTGCA 
                   
                   
                   
                   
                 TIVE 
                   
                 (CHIMPANZEE), 357 aa (fragment). 
               
               
                   
                   
                   
                 GCTGTAGTCAC 
               
               
                   
                   
                   
                 TGGAGCTGC 
               
               
                 1137-1138 
                 cg43923640 
                  511 
                 TCCGCTGAGG 
                 T 
                 C 
                 Phe 
                 Leu 
                 NON- 
                 oncogene 
                 Human Gene Similar to SWISSPROT-ID: P24407 
                 1.30E−34 
                  1 
               
               
                   
                   
                   
                 AAATTCAAGCT 
                   
                   
                 (1217) 
                 (1218) 
                 CONSERVA 
                   
                 RAS-RELATED PROTEIN RAB-8 (ONCOGENE 
               
               
                   
                   
                   
                 GGTG[T/C]TCCT 
                   
                   
                   
                   
                 TIVE 
                   
                 C-MEL) -  HOMO SAPIENS  (HUMAN), AND 
               
               
                   
                   
                   
                 GGGGGAGCAA 
                   
                   
                   
                   
                   
                   
                   CANIS FAMILIARIS  (DOG), 207 aa. 
               
               
                   
                   
                   
                 AGCGTTGGAAA 
               
               
                 1139-1140 
                 cg27790564 
                  15 
                 GGTACCACAGA 
                 C 
                 T 
                 Ala 
                 Thr 
                 NON- 
                 protease 
                 Human Gene Similar to SWISSNEW-ID: P53616 
                 9.70E−31 
               
               
                   
                   
                   
                 TAG[C/T]AATGG 
                   
                   
                 (1219) 
                 (1220) 
                 CONSERVA- 
                   
                 PROTEASOME COMPONENT SUN4 - 
               
               
                   
                   
                   
                 AGCCGGAGAC 
                   
                   
                   
                   
                 TIVE 
                   
                   SACCHAROMYCES CEREVISIAE  (BAKER&#39;S 
               
               
                   
                   
                   
                 CTTGTTAACA 
                   
                   
                   
                   
                   
                   
                 YEAST), 420 aa.|pcls: SWISSPROT-ID: P53616 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 PROTEASOME COMPONENT SUN4 - 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   SACCHAROMYCES CEREVISIAE  (BAKER&#39;S 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 YEAST), 420 aa. 
               
               
                 1141-1142 
                 cg39517733 
                  241 
                 CCCTCATCAAA 
                 G 
                 A 
                 Pro 
                 Ser 
                 NON- 
                 struct 
                 Human Gene Similar to SPTREMBL- 
                 3.90E−36 
               
               
                   
                   
                   
                 GATGGGGGCT 
                   
                   
                 (1221) 
                 (1222) 
                 CONSERVA- 
                   
                 ID: Q14425 GASTRIC MUCIN -  HOMO SAPIENS   
               
               
                   
                   
                   
                 GTTG[G/A]TGG 
                   
                   
                   
                   
                 TIVE 
                   
                 (HUMAN), 850 aa (fragment). 
               
               
                   
                   
                   
                 GCACTTGGGG 
               
               
                   
                   
                   
                 TAGCAGCCTTC 
               
               
                   
                   
                   
                 C 
               
               
                 1144-1143 
                 cg39517733 
                  88 
                 CCAGCATCAT 
                 T 
                 C 
                 Ser 
                 Gly 
                 NON- 
                 struct 
                 Human Gene Similar to SPTREMBL-ID: Q14425 
                 3.9E−36 
               
               
                   
                   
                   
                 GGGTACAGTT 
                   
                   
                 (1223) 
                 (1224) 
                 CONSERVA- 
                   
                 GASTRIC MUCIN -  HOMO SAPIENS  (HUMAN), 
               
               
                   
                   
                   
                 CACAC[T/C]A 
                   
                   
                   
                   
                 TIVE 
                   
                 850 aa (fragment). 
               
               
                   
                   
                   
                 CTCTCCGTAC 
               
               
                   
                   
                   
                 AAACGCAGG 
               
               
                   
                   
                   
                 AATAA 
               
               
                 1145-1146 
                 cg39565684 
                  240 
                 TTCTGGGATAA 
                 C 
                 T 
                 Arg 
                 Gln 
                 NON- 
                 synthase 
                 Human Gene Similar to SWISSNEW-ID: P53167 
                 1.40E−33 
               
               
                   
                   
                   
                 GGTATTGGTAC 
                   
                   
                 (1225) 
                 (1226) 
                 CONSERVA- 
                   
                 PSEUDOURIDYLATE SYNTHASE 2 
               
               
                   
                   
                   
                 CAT[C/T]GGGA 
                   
                   
                   
                   
                 TIVE 
                   
                 (EC 4.2.1.70) (PSEUDOURIDINE SYNTHASE 2) - 
               
               
                   
                   
                   
                 ATCGCACGCG 
                   
                   
                   
                   
                   
                   
                   SACCHAROMYCES CEREVISIAE  (BAKER&#39;S 
               
               
                   
                   
                   
                 GATCTAGCATT 
                   
                   
                   
                   
                   
                   
                 YEAST), 370 aa.″pcls: SWISSPROT-ID: P53167 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 PSEUDOURIDYLATE SYNTHASE 2 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (EC 4.2.1.70) (PSEUDOURIDINE SYNTHASE 2) - 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   SACCHAROMYCES CEREVISIAE  (BAKER&#39;S 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 YEAST), 370 aa.|pcls: SPTREMBL-ID: Q06713 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 PSEUDOURIDINE SYNTHASE 2 - 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   SACCHAROMYCES CEREVISIAE  (BAKER&#39;S 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 YEAST), 370 aa. 
               
               
                 1147-1148 
                 cg32152874 
                  143 
                 CAAGGTGTACG 
                 A 
                 C 
                 Met 
                 Leu 
                 NON- 
                 transcriptfactor 
                 Human Gene Similar to SPTREMBL-ID: Q24140 
                 1.50E−39 
               
               
                   
                   
                   
                 TGTCCATGCCG 
                   
                   
                 (1227) 
                 (1228) 
                 CONSERVA- 
                   
                 NEURON SPECIFIC ZINC FINGER TRANSCRIP- 
               
               
                   
                   
                   
                 GCC[A/C]TGGC 
                   
                   
                   
                   
                 TIVE 
                   
                 TION FACTOR -  DROSOPHILA   
               
               
                   
                   
                   
                 CATGCACCTGC 
                   
                   
                   
                   
                   
                   
                 
                   MELANOGASTER (FRUIT FLY), 664 aa. 
                 
               
               
                   
                   
                   
                 TCACGCACGA 
                   
                   
                   
                   
                   
                   
                   
               
               
                 1149-1150 
                 cg43025141 
                  686 
                 CTACGCCAAGC 
                 G 
                 A 
                 Ala 
                 Thr 
                 NON- 
                 transferase 
                 Human Gene Similar to SPTREMBL-ID: O08832 
                 1.10E−49 
               
               
                   
                   
                   
                 GCAACGCCCT 
                   
                   
                 (1229) 
                 (1230) 
                 CONSERVA- 
                   
                 POLYPEPTIDE GALNAC TRANSFERASE-T4 - 
               
               
                   
                   
                   
                 GCGC[G/A]CCG 
                   
                   
                   
                   
                 TIVE 
                   
                   MUS MUSCULUS  (MOUSE), 578 aa. 
               
               
                   
                   
                   
                 CCGAGGTGTG 
               
               
                   
                   
                   
                 GATGGATGACT 
               
               
                   
                   
                   
                 T 
               
               
                 1151-1152 
                 cg44028935 
                  80 
                 GGCAGGATGA 
                 T 
                 A 
                 Leu 
                 Gln 
                 NON- 
                 ubiquitin 
                 Human Gene Similar to SWISSPROT-ID: P52491 
                 3.00E−36 
               
               
                   
                   
                   
                 TCAAGCTGTTC 
                   
                   
                 (1231) 
                 (1232) 
                 CONSERVA- 
                   
                 UBIQUITIN-CONJUGATING ENZYME E2-21.2 
               
               
                   
                   
                   
                 TCGC[T/A]GAA 
                   
                   
                   
                   
                 TIVE 
                   
                 KD (EC 6.3.2.19) (UBIQUITIN-PROTEIN 
               
               
                   
                   
                   
                 GCAGCAGAAG 
                   
                   
                   
                   
                   
                   
                 LIGASE) (UBIQUITIN CARRIER PROTEIN) - 
               
               
                   
                   
                   
                 AAGGAGGAGG 
                   
                   
                   
                   
                   
                   
                   SACCHAROMYCES CEREVISIAE  (BAKER&#39;S 
               
               
                   
                   
                   
                 AG 
                   
                   
                   
                   
                   
                   
                 YEAST), 188 aa. 
               
               
                 1153-1154 
                 cg44028935 
                  82 
                 CAGGATGATCA 
                 A 
                 C 
                 Lys 
                 Gln 
                 NON- 
                 ubiquitin 
                 Human Gene Similar to SWISSPROT-ID: P52491 
                 3.00E−36 
                  8 
               
               
                   
                   
                   
                 AGCTGTTCTCG 
                   
                   
                 (1233) 
                 (1234) 
                 CONSERVA- 
                   
                 UBIQUITIN-CONJUGATING ENZYME E2-21.2 
               
               
                   
                   
                   
                 CTG[A/C]AGCA 
                   
                   
                   
                   
                 TIVE 
                   
                 KD (EC 6.3.2.19) (UBIQUITIN-PROTEIN 
               
               
                   
                   
                   
                 GCAGAAGAAG 
                   
                   
                   
                   
                   
                   
                 LIGASE) (UBIQUITIN CARRIER PROTEIN) - 
               
               
                   
                   
                   
                 GAGGAGGAGT 
                   
                   
                   
                   
                   
                   
                   SACCHAROMYCES CEREVISIAE  (BAKER&#39;S 
               
               
                   
                   
                   
                 C 
                   
                   
                   
                   
                   
                   
                 YEAST), 188 aa. 
               
               
                 1155-1156 
                 cg44028935 
                  83 
                 AGGATGATCAA 
                 A 
                 T 
                 Lys 
                 Met 
                 NON- 
                 ubiquitin 
                 Human Gene Similar to SWISSPROT-ID: P52491 
                 3.00E−36 
                  8 
               
               
                   
                   
                   
                 GCTGTTCTCGC 
                   
                   
                 (1235) 
                 (1236) 
                 CONSERVA- 
                   
                 UBIQUITIN-CONJUGATING ENZYME E2-21.2 
               
               
                   
                   
                   
                 TGA[A/T]GCAG 
                   
                   
                   
                   
                 TIVE 
                   
                 KD (EC 6.3.2.19) (UBIQUITIN-PROTEIN 
               
               
                   
                   
                   
                 CAGAAGAAGG 
                   
                   
                   
                   
                   
                   
                 LIGASE) (UBIQUITIN CARRIER PROTEIN) - 
               
               
                   
                   
                   
                 AGGAGGAGTC 
                   
                   
                   
                   
                   
                   
                   SACCHAROMYCES CEREVISIAE  (BAKER&#39;S 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 YEAST), 188 aa. 
               
               
                 1157-1158 
                 cg44028935 
                  86 
                 ATGATCAAGCT 
                 A 
                 G 
                 Gln 
                 Arg 
                 NON- 
                 ubiquitin 
                 Human Gene Similar to SWISSPROT-ID: P52491 
                 3.00E−36 
                  8 
               
               
                   
                   
                   
                 GTTCTCGCTGA 
                   
                   
                 (1237) 
                 (1238) 
                 CONSERVA- 
                   
                 UBIQUITIN-CONJUGATING ENZYME E2-21.2 
               
               
                   
                   
                   
                 AGC[A/G]GCAG 
                   
                   
                   
                   
                 TIVE 
                   
                 KD (EC 6.3.2.19) (UBIQUITIN-PROTEIN 
               
               
                   
                   
                   
                 AAGAAGGAGG 
                   
                   
                   
                   
                   
                   
                 LIGASE) (UBIQUITIN CARRIER PROTEIN) - 
               
               
                   
                   
                   
                 AGGAGTCGGC 
                   
                   
                   
                   
                   
                   
                   SACCHAROMYCES CEREVISIAE  (BAKER&#39;S 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 YEAST), 188 aa. 
               
               
                 1159-1160 
                 cg39548335 
                  228 
                 ATCAGTACCTC 
                 G 
                 A 
                 Gln 
                 End 
                 NON- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: P43618 
                 2.90E−48 
               
               
                   
                   
                   
                 ATCCTTGAGAC 
                   
                   
                 (1239) 
                 (1240) 
                 CONSERVA- 
                 FIED 
                 HYPOTHETICAL 41.3 KD PROTEIN IN SAP155- 
               
               
                   
                   
                   
                 GTT[G/A]TTCTT 
                   
                   
                   
                   
                 TIVE 
                   
                 YMR31 INTERGENIC REGION -  Saccharomyces   
               
               
                   
                   
                   
                 CAAGGGCTCTC 
                   
                   
                   
                   
                   
                   
                   cerevisiae  (Baker&#39;s yeast), 361 aa. 
               
               
                   
                   
                   
                 TCCCGAAAG 
               
               
                 1161-1162 
                 cg39548335 
                  48 
                 TCATCTATTAG 
                 T 
                 C 
                 Thr 
                 Ala 
                 NON- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: P43618 
                 2.90E−48 
               
               
                   
                   
                   
                 ATTCCGTGCTT 
                   
                   
                 (1241) 
                 (1242) 
                 CONSERVA- 
                 FIED 
                 HYPOTHETICAL 41.3 KD PROTEIN IN SAP155- 
               
               
                   
                   
                   
                 GAG[T/C]TTTAT 
                   
                   
                   
                   
                 TIVE 
                   
                 YMR31 INTERGENIC REGION -  Saccharomyces   
               
               
                   
                   
                   
                 TAGTAGTTGTA 
                   
                   
                   
                   
                   
                   
                   cerevisiae  (Baker&#39;s yeast), 361 aa. 
               
               
                   
                   
                   
                 TCGTTGCCT 
               
               
                 1163-1164 
                 cg39510144 
                  109 
                 ATTGGGTTGTA 
                 C 
                 T 
                 Pro 
                 Leu 
                 NON- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 2.00E−47 
               
               
                   
                   
                   
                 TGCAGAACTCT 
                   
                   
                 (1243) 
                 (1244) 
                 CONSERVA- 
                 FIED 
                 Q12284 ERV2 PROTEIN PRECURSOR - 
               
               
                   
                   
                   
                 ATC[C/T]ATGCG 
                   
                   
                   
                   
                 TIVE 
                   
                   Saccharomyces cerevisiae  (Baker&#39;s yeast), 196 aa. 
               
               
                   
                   
                   
                 GGGAATGTTCA 
               
               
                   
                   
                   
                 TATCACTTT 
               
               
                 1165-1166 
                 cg39565075 
                  28 
                 CGGAGAAGAG 
                 T 
                 G 
                 Phe 
                 Val 
                 NON- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: P36121 
                 1.40E−46 
               
               
                   
                   
                   
                 GAGTCACTGCA 
                   
                   
                 (1245) 
                 (1246) 
                 CONSERVA- 
                 FIED 
                 HYPOTHETICAL 32.1 KD PROTEIN IN DBP7- 
               
               
                   
                   
                   
                 CGTG[T/G]TTCA 
                   
                   
                   
                   
                 TIVE 
                   
                 GCN3 INTERGENIC REGION -  Saccharomyces   
               
               
                   
                   
                   
                 GTATGCTAATA 
                   
                   
                   
                   
                   
                   
                 
                   cerevisiae (Baker&#39;s yeast), 282 aa. 
                 
               
               
                   
                   
                   
                 GACCAAGGCT 
               
               
                 1167-1168 
                 cg21427396 
                  193 
                 TCAAACCCATG 
                 C 
                 T 
                 Arg 
                 Cys 
                 NON- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: P30870 
                 7.60E−44 
               
               
                   
                   
                   
                 GTCGAGAGTG 
                   
                   
                 (1247) 
                 (1248) 
                 CONSERVA- 
                 FIED 
                 GLUTAMATE-AMMONIA-LIGASE ADENYLYL- 
               
               
                   
                   
                   
                 GGAG[C/T]GTT 
                   
                   
                   
                   
                 TIVE 
                   
                 TRANSFERASE (EC 2.7.7.42) (GLUTAMINE- 
               
               
                   
                   
                   
                 ATGCCATGGTT 
                   
                   
                   
                   
                   
                   
                 SYNTHETASE ADENYLYLTRANSFERASE) 
               
               
                   
                   
                   
                 AAAGCCCGTGT 
                   
                   
                   
                   
                   
                   
                 (ATASE) -  Escherichia coli , 946 aa. 
               
               
                 1169-1170 
                 cg34394308 
                  431 
                 GTTGATGCTGC 
                 G 
                 A 
                 Gly 
                 Asp 
                 NON- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: P50442 
                 1.50E−42 
               
               
                   
                   
                   
                 TCAGCCGGCG 
                   
                   
                 (1249) 
                 (1250) 
                 CONSERVA- 
                 FIED 
                 GLYCINE AMIDINOTRANSFERASE PRE- 
               
               
                   
                   
                   
                 CACG[G/A]CAC 
                   
                   
                   
                   
                 TIVE 
                   
                 CURSOR (EC 2.1.4.1) (L-ARGININE:GLYCINE 
               
               
                   
                   
                   
                 GCCTCCAGAAT 
                   
                   
                   
                   
                   
                   
                 AMIDINOTRANSFERASE) (TRANSAMIDINASE) 
               
               
                   
                   
                   
                 TGTGCTACTCG 
                   
                   
                   
                   
                   
                   
                 (AT) -  Rattus norvegicus  (Rat), 423 aa. 
               
               
                 1171-1172 
                 cg43129081 
                  415 
                 CCTCGATCTCC 
                 G 
                 A 
                 Ala 
                 Thr 
                 NON- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 3.70E−41 
               
               
                   
                   
                   
                 TGACCTCGTGA 
                   
                   
                 (1251) 
                 (1252) 
                 CONSERVA- 
                 FIED 
                 P39189 !!!! ALU SUBFAMILY SB WARNING 
               
               
                   
                   
                   
                 TCC[G/A]CCCA 
                   
                   
                   
                   
                 TIVE 
                   
                 ENTRY -  Homo sapiens  (Human), 587 aa. 
               
               
                   
                   
                   
                 CCTTGGCCTCC 
               
               
                   
                   
                   
                 CAAAGTGCTG 
               
               
                 1173-1174 
                 cg29693502 
                  197 
                 CTGATCGACGT 
                 T 
                 G 
                 Asn 
                 Thr 
                 NON- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 3.00E−39 
               
               
                   
                   
                   
                 ATTCCAACAGC 
                   
                   
                 (1253) 
                 (1254) 
                 CONSERVA- 
                 FIED 
                 Q10379 PROBABLE GLUTAMATE-AMMONIA- 
               
               
                   
                   
                   
                 TCA]T/G]TCGTC 
                   
                   
                   
                   
                 TIVE 
                   
                 LIGASE ADENYLYLTRANSFERASE 
               
               
                   
                   
                   
                 AACTCCCGGTC 
                   
                   
                   
                   
                   
                   
                 (EC 2.7.7.42) (GLUTAMINE-SYNTHETASE 
               
               
                   
                   
                   
                 GCCGGCACC 
                   
                   
                   
                   
                   
                   
                 ADENYLYLTRANSFERASE) (ATASE) - 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 Mycobacterium 
               
               
                 1175-1176 
                 cg27850036 
                  136 
                 TAGGTGTCTAG 
                 C 
                 T 
                 Gly 
                 Ser 
                 NON- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSNEW-ACC: P11653 
                 1.00E−38 
               
               
                   
                   
                   
                 CCAGTCCATGT 
                   
                   
                 (1255) 
                 (1256) 
                 CONSERVA- 
                 FIED 
                 METHYLMALONYL COA MUTASE ALPHA- 
               
               
                   
                   
                   
                 CAC[C/T]GTAGA 
                   
                   
                   
                   
                 TIVE 
                   
                 SUBUNIT (EC 5.4.99.2) (MCM-ALPHA) - 
               
               
                   
                   
                   
                 CGTCCTCGGA 
                   
                   
                   
                   
                   
                   
                   Propionibacterium freudenreichii shermanii , 727 aa. 
               
               
                   
                   
                   
                 GTAGAGGTGA 
               
               
                 1177-1178 
                 cg43936560 
                 1406 
                 TTGGGCAGCTT 
                 G 
                 C 
                 Ala 
                 Pro 
                 NON- 
                 UNCLASSI- 
                 Human Gene Similar to SPTREMBL-ACC: Q69566 
                 4.70E−36 
               
               
                   
                   
                   
                 ATCTGTGTGCC 
                   
                   
                 (1257) 
                 (1258) 
                 CONSERVA- 
                 FIED 
                 (HHV-6) U1102, VARIANT A DNA, COMPLETE 
               
               
                   
                   
                   
                 CAG[G/C]CGGC 
                   
                   
                   
                   
                 TIVE 
                   
                 VIRION GENOME - HUMAN HERPESVIRUS-6, 
               
               
                   
                   
                   
                 ATATCTGTGCA 
                   
                   
                   
                   
                   
                   
                 413 aa. 
               
               
                   
                   
                   
                 TGTGCGTGTG 
               
               
                 1179-1180 
                 cg42538578 
                  142 
                 GCAGCACTTG 
                 C 
                 T 
                 Cys 
                 Tyr 
                 NON- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 7.40E−34 
                  8 
               
               
                   
                   
                   
                 GCCTTCCCTCT 
                   
                   
                 (1259) 
                 (1260) 
                 CONSERVA- 
                 FIED 
                 Q09753 BETA-DEFENSIN 1 PRECURSOR 
               
               
                   
                   
                   
                 GTAA[C/T]AGGT 
                   
                   
                   
                   
                 TIVE 
                   
                 (HBD-1) (DEFENSIN, BETA 1) -  Homo sapiens   
               
               
                   
                   
                   
                 GCCTTGAATTT 
                   
                   
                   
                   
                   
                   
                 (Human), 68 aa. 
               
               
                   
                   
                   
                 TGGTAAAGAT 
               
               
                 1181-1182 
                 cg42475469 
                  376 
                 CTGACCTCAAG 
                 C 
                 T 
                 Glu 
                 Lys 
                 NON- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 5.70E−32 
               
               
                   
                   
                   
                 TGATCCACCTG 
                   
                   
                 (1261) 
                 (1262) 
                 CONSERVA- 
                 FIED 
                 P39194 !!!! ALU SUBFAMILY SQ WARNING 
               
               
                   
                   
                   
                 CCT[C/T]AGCCT 
                   
                   
                   
                   
                 TIVE 
                   
                 ENTRY -  Homo sapiens  (Human), 593 aa. 
               
               
                   
                   
                   
                 CCCAAAGTGCT 
               
               
                   
                   
                   
                 GGGATTACA 
               
               
                 1183-1184 
                 cg27847601 
                  280 
                 CTGAGGTGGG 
                 A 
                 G 
                 Lys 
                 Glu 
                 NON- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 1.00E−31 
               
               
                   
                   
                   
                 AGGACTGCCT 
                   
                   
                 (1263) 
                 (1264) 
                 CONSERVA- 
                 FIED 
                 P39191 !!!! ALU SUBFAMILY SB2 WARNING 
               
               
                   
                   
                   
                 GAACC[A/G]AG 
                   
                   
                   
                   
                 TIVE 
                   
                 ENTRY -  Homo sapiens  (Human), 603 aa. 
               
               
                   
                   
                   
                 GAGGTGGAGG 
               
               
                   
                   
                   
                 CTGCAGTGAG 
               
               
                   
                   
                   
                 CCA 
               
               
                 1185-1186 
                 cg27847601 
                  298 
                 CTGAACCAAGG 
                 G 
                 A 
                 Val 
                 Met 
                 NON- 
                 UNCLASSI- 
                 Human Gene Similar to SWISSPROT-ACC: 
                 1.00E−31 
               
               
                   
                   
                   
                 AGGTGGAGGC 
                   
                   
                 (1265) 
                 (1266) 
                 CONSERVA- 
                 FIED 
                 P39191 !!!! ALU SUBFAMILY SB2 WARNING 
               
               
                   
                   
                   
                 TGCA[G/A]TGA 
                   
                   
                   
                   
                 TIVE 
                   
                 ENTRY -  Homo sapiens  (Human), 603 aa. 
               
               
                   
                   
                   
                 GCCAAGATCAC 
               
               
                   
                   
                   
                 AGCACTATGCT 
               
               
                 1187-1188 
                 cg44931270 
                 1970 
                 CGGCGCCGGG 
                 C 
                 gap 
                 Gln 
                 His 
                 FRAMESHIFT 
                 collagen 
                 Human Gene Similar to SPTREMBL-ID: Q28396 
                 2.10E−37 
               
               
                   
                   
                   
                 AGGCTGTGGG 
                   
                 (1267) 
                 (1268) 
                   
                   
                   
                 TYPE II COLLAGEN -  EQUUS CABALLUS   
               
               
                   
                   
                   
                 TCTGG[C/gap]T 
                   
                   
                   
                   
                   
                   
                 (HORSE), 1418 aa. 
               
               
                   
                   
                   
                 GCGCACGGTC 
               
               
                   
                   
                   
                 TCGGTCAGCA 
               
               
                   
                   
                   
                 GAGC 
               
               
                 1189-1190 
                 cg43925450 
                  333 
                 GATCTGTCAAT 
                 gap 
                 T 
                 Leu 
                 Ser 
                 FRAMESHIFT 
                 glycoprotein 
                 Human Gene Similar to TREMBLNEW-ID: 
                 3.80E−37 
                 17 
               
               
                   
                   
                   
                 TTAAGCTGGTT 
                   
                   
                 (1269) 
                 (1270) 
                   
                   
                 E1249608 MEMBRANE-BOUND SMALL GTP- 
               
               
                   
                   
                   
                 CTG[gap/T]CTG 
                   
                   
                   
                   
                   
                   
                 BINDING - LIKE PROTEIN -  ARABIDOPSIS   
               
               
                   
                   
                   
                 GGGGAGTCTG 
                   
                   
                   
                   
                   
                   
                   THALIANA  (MOUSE-EAR CRESS), 217 aa. 
               
               
                   
                   
                   
                 CGGTAGGCAA 
               
               
                   
                   
                   
                 AT 
               
               
                 1191-1192 
                 cg43941918 
                  724 
                 CAGCCACAGTT 
                 gap 
                 T 
                 Val 
                 Ser 
                 FRAMESHIFT 
                 immunoglob 
                 Human Gene Similar to TREMBLNEW-ID: 
                 2.80E−42 
               
               
                   
                   
                   
                 CGTTTGATCTC 
                   
                   
                 (1271) 
                 (1272) 
                   
                   
                 G240581 IMMUNOGLOBULIN G2B VARIABLE 
               
               
                   
                   
                   
                 CAC[gap/T]CTT 
                   
                   
                   
                   
                   
                   
                 REGION LIGHT CHAIN, AUTOANTOBODY 
               
               
                   
                   
                   
                 GGTCCCTTGG 
                   
                   
                   
                   
                   
                   
                 BV04-01 VARIABLE REGION LIGHT CHAIN - 
               
               
                   
                   
                   
                 CCGAAAGTGC 
                   
                   
                   
                   
                   
                   
                 MUSSP, 113 aa. 
               
               
                   
                   
                   
                 GC 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
            
               
                   
               
               
                 SEQUENCE LISTING 
               
            
           
           
               
            
               
                 The patent contains a lengthy “Sequence Listing” section. A copy of the “Sequence Listing” is available in electronic form from the USPTO 
               
               
                 web site (http://seqdata.uspto.gov/sequence.html?DocID=06670464B1). An electronic copy of the “Sequence Listing” will also be available from the 
               
               
                 USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).