Patent Publication Number: US-11649104-B2

Title: Connecting and container system

Description:
CROSS REFERENCE TO RELATED APPLICATION 
     This application is a continuation of commonly-owned, U.S. patent application Ser. No. 16/924,862 filed Jul. 9, 2020, issued as U.S. Pat. No. 11,046,499, which is a continuation of U.S. patent application Ser. No. 16/040,891 filed Jul. 20, 2018, issued as U.S. Pat. No. 10,737,868, which is a division of U.S. patent application Ser. No. 15/181,534, filed Jun. 14, 2016, issued as U.S. Pat. No. 10,053,277, which claims the benefit of priority to European Application No. 15 020 096.2 filed Jun. 16, 2015 and European Application No. 15 020 095.4 filed Jun. 16, 2015, the contents of which are incorporated herein by reference in their entirety. 
    
    
     BACKGROUND OF THE INVENTION 
     Field of the Invention 
     The present invention relates in principle to the provision of a fluidic connection. In particular, the present invention relates to a connecting system for providing a fluidic connection, preferably between containers, a method, a container system and a use. In addition, the present invention relates to a connecting arrangement, a connecting system, a container, a container system, a use and a method. 
     Description of Related Art 
     In the medical sphere it is regularly necessary to transfer substances from one container into another. For example, mixtures of medicaments or substances are produced in a mixing bottle, by transferring first the contents of one container and then of a second container into the mixing bottle, then sealing the mixing bottle, and producing a mixture by agitation. 
     In some cases, which are also a focus of the present invention, substances stored in different containers have to be mixed under sterile conditions or while preventing the ingress of foreign substances. The present invention thus also relates in particular to the provision of a sterile fluidic connection or a connection which prevents the ingress of foreign substances such as germs. 
     In this sector, International Patent Application WO 2013/104550 A, for example, discloses a kit for the production of a combined vaccine, wherein two bottles each have a septum and the kit comprises a double needle for piercing both septa and thereby providing a continuous fluidic connection between the bottles. However, it has been found that the provision of a fluidic connection by means of a double needle or the like leads to a relatively high flow resistance, which may make a transfer between the bottles a slow process. 
     SUMMARY OF THE INVENTION 
     The problem on which the present invention is based is therefore to indicate a connecting system, a method, a container system and a use, as well as a connecting arrangement, a connecting system, a container, a container system, a use and a method, by which the production of a mixture can be simplified or speeded up and/or a specific mixing ratio can be ensured. 
     This problem is solved by a connecting system, a method, a container system, a connecting arrangement, a connecting system, a container, a connection and a method as described herein. 
     In a first aspect the present invention relates to a connecting system for providing a (continuous) fluidic connection, preferably between containers, the connecting system comprising at least two connecting arrangements configured to provide the fluidic connection, namely a first connecting arrangement and a second connecting arrangement, which are fluidically sealed in an initial state, the first connecting arrangement comprising an, opening region, in particular being, film-shaped, brittle and/or unstable wherein the first connecting arrangement is deformable outside the opening region and is configured so that the deformation opens the first connecting arrangement in the opening region. 
     Advantageously, during opening by deformation a fluidic connection with a large cross-section can be produced rapidly. 
     In another aspect which may also be implemented independently, the present invention relates to a container system having at least two containers, preferably bottles, and the connecting system according to the above-mentioned aspect, wherein the containers each comprise at least one connecting arrangement of the connecting system for producing a fluidic connection between the containers. 
     In this way it is possible to obtain a fluidic connection having a reliably sufficient large cross-section for fast and total mixing of the container contents. 
     In another aspect which may also be implemented independently, the present invention relates to a use of a container system wherein a first container comprises a first substance, particularly a first vaccine against a first disease, while a second container comprises a second substance, particularly a second vaccine against a second disease different from the first, for the preparation of a mixture of substances, particularly for the preparation of a combined vaccine for simultaneous immunization against different diseases, wherein the containers are fluidically connected to one another by means of the connecting arrangement, so that the substances are mixed together, particularly to form the combined vaccine. 
     In this way, substances which are incompatible with one another, particularly vaccines, can be quickly and reliably mixed together, immediately before being used and administered jointly, thereby enabling saving time and reducing stress. 
     In another aspect which may also be implemented independently, the present invention relates to a connecting arrangement for producing a fluidic connection between containers, hereinafter referred to as the first connecting arrangement, wherein the first connecting arrangement has a preferably rigid closure device, particularly a closure plate, which is sealingly held on a holding portion of the connecting arrangement in an initial state by means of a frangible point/line, particularly a fragile thin point/line, the holding portion being movable relative to the closure device by deformation, as a result of which the first connecting arrangement can be opened by breaking, particularly tearing/cracking, the frangible point/line. 
     Opening by deformation in conjunction with the closure device by tearing the frangible point has the advantage that the opening process is particularly simple and effective and is particularly reliable thanks to the use of the closure device, as by using the closure device it is possible to generate high tensile and/or shear stresses in the frangible point/line which assist the opening process. 
     In another aspect which may also be implemented independently, the present invention relates to a connecting system with a first connecting arrangement according to the previous aspect, which may also be implemented independently, and a second connecting arrangement comprising a deforming device corresponding to the holding portion, formed in particular by a mouth-shaped portion, wherein the connecting arrangements can be sealingly inserted in one another and, when the connecting arrangements are rotated relative to one another, the first connecting arrangement can be opened, as a result of deformation of the holding portion by means of the deforming device, in order to produce the fluidic connection. 
     Because the holding portion corresponds to the deforming device, the holding portion can be effectively deformed such that opening in the manner described can be ensured. 
     In another aspect which may also be implemented independently, the present invention relates to a container, particularly a bottle, having a proposed first connecting arrangement, wherein the holding portion is movable relative to the connecting arrangement by deformation, as a result of which the first connecting arrangement can be opened by tearing of the frangible point/line, the container preferably comprising the connecting arrangement on a side remote from a removal opening. This results in corresponding advantages. 
     In another aspect which may also be implemented independently, the present invention relates to a container system having at least two containers, a first container comprising a connecting arrangement according to one of the preceding aspects and a second container comprising a second connecting arrangement according to one of the preceding aspects, the connecting arrangements corresponding to each other. The first connecting arrangement comprises a severing element, particularly a piercing and/or cutting edge, by means of which the second connecting arrangement can be opened. Alternatively or additionally, the second connecting arrangement comprises a deforming device for opening the first container by means of the first connecting arrangement by deforming the holding portion. Alternatively or additionally, the connecting arrangements are configured to produce the fluidic connection by mutual opening, the first connecting arrangement opening the second connecting arrangement and the second connecting arrangement opening the first connecting arrangement, thus producing the fluidic connection. 
     In another aspect which may also be implemented independently, the present invention relates to a use of the connecting arrangement, the connecting system, the container and/or the container system according to one of the preceding aspects, for preparing a mixture of substances, preferably a medicament, particularly a vaccine or combined vaccine, by creating the fluidic connection and mixing substances that have been stored separately. This mixing can be carried out particularly effectively and reliably in this manner, as the present invention makes it possible to produce a relatively large hydraulic cross-section between containers, thus enabling rapid and reliable mixing. A particular advantage is that even viscous, liquid substances, particularly vaccines, can be mixed quickly, efficiently and effectively. 
     In another aspect which may also be implemented independently, the present invention relates to a method for producing the connecting arrangement, the connecting system, the container and/or the container system according to one of the preceding aspects, by injection-molding the closure device, the frangible point and the holding portion in a common step, preferably starting from the closure device. 
     Injection molding of the connecting arrangement, in which the thermally liquefied plastics is injected into a mound corresponding to the closure device and is then forced through a mound representing the frangible point, has proved particularly reliable as a method for producing the thin and consequently fragile frangible point. This method also makes it possible to avoid leaks in the region of the delicate frangible point and therefore improves the yield. 
     The connecting system is preferably suitable and particularly advantageous for providing a fluidic connection between containers, but may alternatively or additionally also be used for some other fluidic connection or attachment, for example of a container to some other apparatus, or may be used quite independently of any containers. 
     The proposed connecting system preferably comprises at least or precisely two connecting arrangements. The connecting arrangements are preferably formed to be complementary and/or to correspond to one another. This has the advantage that the fluidic connection can only be produced with connecting arrangements that fit one another. The preferably complementary and/or corresponding configuration of the connecting arrangement also has the advantage that the connecting arrangements fit one another in such a way that the fluidic connection can be produced. 
     The connecting arrangements are preferably fluidically sealed in each case in an initial state. This makes it possible to produce a mixture as required or on the spot, and to use containers which each comprise the respective connecting arrangements, but also to use them separately or independently of one another. 
     It is provided that the connecting arrangements are configured for mutual opening, the continuous fluidic connection being produced by the mutual opening of the connecting arrangements. 
     Preferably the first connecting arrangement is configured for opening another, second connecting arrangement. It is also preferable that the second connecting arrangement should be configured for opening the first connecting arrangement. This enables mutual opening of the connecting arrangements. 
     According to another aspect of the present invention which may also be implemented independently, the proposed connecting system comprises a plurality of containers, each comprising both one of the connecting arrangements and also a withdrawal/removal opening. 
     According to another aspect of the present invention which may also be implemented independently, the fluidic connection can be produced by deformation of at least one of the connecting arrangements, preferably by destruction of an opening region of the connecting arrangements by deforming the connecting arrangement outside an opening region. 
     It is envisaged, in particular, that the connecting arrangements each serve as, comprise or are embodied as means for opening the respective other connecting arrangement. Such means are preferably secured or fixedly connected to or formed in one piece with the respective connecting arrangement. This advantageously makes it possible to produce the fluidic connection without the use of tools (apart from the connecting arrangements themselves) and particularly enables uncomplicated handling. Advantageously, in particular, there is no need for any separate tools that have to be moved or operated separately from the connecting arrangements, and for this reason the proposed connecting system has low complexity, is cheap to manufacture, as well as being reliable and robust. 
     Preferably, the fluidic connection and/or a mechanical connection of the connecting arrangements or containers is permanent and/or non-releasable, once produced. Advantageously this can effectively prevent even partial mixing and/or the ingress of foreign substances during or after the production of the fluidic connection. Thanks to the preferably permanent and/or non-releasable fluidic connection there is no need for the use of septa or the like, even when sterility is required, to produce the fluidic connection. Therefore, a relatively large opening or an opening with a large cross-section compared with a needle can be obtained, allowing faster transfer and mixing of the substances. 
     A connection is non-releasable in the sense of the present invention particularly when the connection can only be opened up again by damaging or destroying the structure, not manually and/or only using tools. A non-releasable connection is particularly a connection produced using snap-fit hooks. However, other solutions are also possible here. 
     Preferably, at least one, preferably both, of the connecting arrangements (each) comprises an opening region to be opened by another of the connecting arrangements. Particularly preferably, the opening region comprises or is formed with or by a film-shaped portion, a frangible point, a weakened area, a tapering of a wall, a film, particularly a sealing film, membrane, membrane-shaped portion and/or other construction of a part or portion of the connecting arrangement provided by constructive or mechanical or physical measures or arrangements, which enables an opening to be made by the action of another connecting arrangement, particularly by destruction, bursting, tearing and/or detachment of the opening region, without otherwise adversely affecting the function and structure of the connecting arrangement. In particular, the (film-shaped) opening region is a mechanically weak or weakened wall portion. An opening region may be breakable, fragile and/or brittle and/or may be, form or comprise a frangible point. The use of the opening region has the advantage that an opening with a relatively large cross-section of passage can be produced simply and quickly. This enables rapid mixing and a homogeneous mixing result, even when the containers are at least substantially filled with liquid and/or solid substances. 
     The connecting arrangement or arrangements is or are preferably designed for one-time and/or irreversible opening, particularly with or by means of the opening region or regions. An opening formed with or by means of or in the connecting system is thus preferably not reclosable. 
     An opening is non-reclosable or irreversibly opened in the sense of the present invention particularly when it can only be reclosed using special tools and/or by replacing defective parts or adding new parts. A destroyed sealing film as a preferred form of an opened opening region is preferably deemed to be non-reclosable or irreversibly opened in the sense of the present invention even when the destroyed sealing film could theoretically be replaced and re-instated using corresponding equipment. 
     The proposed connecting system is hereinafter explained in more detail by reference to two connecting arrangements, the first connecting arrangement and the second connecting arrangement. This does not necessarily imply an opening sequence but serves primarily to differentiate the connecting arrangements. It is thus particularly possible to produce the second connecting arrangement separately and independently from the first connecting arrangement. 
     The connecting arrangements are preferably different and/or are configured differently for opening the other respective connecting arrangement. Thus, preferably, different mechanisms are used for opening the different connecting arrangements, or the connecting arrangements are designed for this purpose. 
     The first connecting arrangement preferably comprises a first opening region. The second connecting arrangement preferably also comprises an opening region, hereinafter referred to as the second opening region. This serves to differentiate between them and preferably does not imply either a sequence or the possibility of producing the second opening region without the first. 
     The second connecting arrangement is preferably configured to open the first connecting arrangement by breaking, severing or destroying the first frangible point. Alternatively, or additionally the first connecting arrangement is configured to open the second connecting arrangement by breaking, severing or destroying the second opening region. The connecting arrangements can thus be opened mutually by one connecting arrangement breaking, severing and/or destroying the opening region of the other connecting arrangement. 
     In a particularly preferred aspect of the present invention which may also be implemented independently, the second opening region of the second connecting arrangement can be pierced by the first connecting arrangement. It is also preferable if the first opening region of the first connecting arrangement can be pierced by means of the second connecting arrangement. 
     Alternatively, or additionally, the first opening region of the first connecting arrangement can be opened by deformation of the first connecting arrangement by means of the second connecting arrangement, particularly a tension cracking, tearing, bursting and/or detachment of the first opening region caused by the deformation. 
     Preferably, the connecting system is configured in a first embodiment to initially open the opening region of the first connecting arrangement with the second connecting arrangement by means of a severing element and then to open the second opening region of the second connecting arrangement by piercing the second opening region with the first connecting arrangement. 
     Preferably, the connecting system is configured in a second embodiment to initially open the second opening region of the second connecting arrangement by piercing the second opening region with the first connecting arrangement and then to open the opening region of the first connecting arrangement by deforming the first connecting arrangement with the second connecting arrangement. 
     The embodiments may also be combined with one another, for example by first opening the opening region of the first connecting arrangement with the second connecting arrangement by means of a severing element, then opening the second opening region of the second connecting arrangement by piercing the second opening region with the first connecting arrangement and subsequently further opening the opening region of the first connecting arrangement with the second connecting arrangement by deforming the first connecting arrangement with the second connecting arrangement. 
     The connecting arrangement may also mutually pierce one another and/or one of the connecting arrangements may pierce the other connecting arrangement and the other connecting arrangement may open the one connecting arrangement by a deformation process. 
     The first and/or second connecting arrangement(s) preferably comprise (in each case) a mouth-shaped portion. The mouth-shaped portion may be formed in the shape of a neck and/or collar and/or a ring or as a tube section or the like. The mouth-shaped portion is particularly configured for conveying fluid after opening. 
     The mouth-shaped portion is preferably configured for producing, forming or surrounding the fluidic connection. For this purpose, the mouth-shaped portion may (in each case) be closed in an initial state. In particular, the (respective) mouth-shaped portion is closed off with the opening region, preferably so as to be openable once and/or irreversibly and/or in fluidtight manner. The mouth-shaped portion may have an open or outer edge on which the opening region is preferably sealingly fixed, arranged or formed. 
     The mouth-shaped portion preferably surrounds the (respective) opening region. In particular, a portion of the connecting arrangement comprising the opening region is connected to the mouth-shaped portion, for example as a result of a sealing film being sealed onto the open edge of the mouth-shaped portion. It is possible, but preferably not necessary, for the opening region to be located inside the mouth-shaped portion. The term “surrounds” in the sense of the present invention preferably means, in connection with the opening region, that the opening region or the portion of the (respective) connecting arrangement forming the opening region is (in an initial state) connected in fluidtight manner to the mouth-shaped portion circumferentially or in some other way on all sides. 
     Preferably, the second connecting arrangement comprises a mouth-shaped portion which surrounds the opening region thereof, while it is also preferable that the connecting arrangement is configured to pierce this opening region. In this way, the second connecting arrangement can be opened. 
     Preferably the opening region of the first connecting arrangement is pierced with a mouth-shaped portion and/or with a severing, perforating or piercing element of the second connecting arrangement. The mouth-shaped portion or the opening region of the second connecting arrangement may thus be configured as a means or tool for opening the first connecting arrangement. 
     Alternatively, or additionally the second connecting arrangement is configured for deforming the mouth-shaped portion of the first connecting arrangement, so that the deformation causes breakage, bursting, tearing and/or detachment of the opening region of the first connecting arrangement, particularly by rotating the connecting arrangements relative to one another. Alternatively, or additionally, the first connecting arrangement is configured for deforming the mouth-shaped portion of the second connecting arrangement, so that the deformation causes breakage of the opening region of the second connecting arrangement, particularly by rotation of the connecting arrangements relative to one another. 
     In the concept described, basically it is functionally possible to replace the first connecting arrangement with the second connecting arrangement. 
     Preferably, the mouth-shaped portion of one of the first and second connecting arrangements is configured to be in alignment in the mouth-shaped portion of the other one of the first and second connecting arrangements, preferably so that the opening region of the other one of the first and second connecting arrangements can be pierced and/or the other one of the first and second connecting arrangements can be opened. 
     In particular, the connecting arrangements are thus structures each having a mouth-shaped portion, which is also closed off in each case with a closure comprising an opening region, particularly a sealing film. In addition, the mouth-shaped portions are formed to be different and complementary, such that the mouth-shaped portion of one of the connecting arrangements is able to break the opening region of the other connecting arrangement. In this way, at least one of the connecting arrangements is opened. 
     The connecting system is preferably constructed such that, in order to produce the continuous fluidic connection, all that is required is to open the two connecting arrangements or to break through the two frangible points of the connecting arrangements. It is thus preferable if the continuous fluidic connection is provided for the first time by opening both connecting arrangements and if opening only one of the connecting arrangements or opening neither one nor the other connecting arrangement results in a fluidic blockade or fluidic shut-off. 
     A continuous fluidic connection in the sense of the present invention means, in particular, that a passage is formed through which a fluid can flow. Preferably, this passage is formed by the mutual opening of the connecting arrangements. 
     Particularly preferably, both connecting arrangements comprise mouth-shaped portions, which are non-round in cross-section and can be arranged one inside the other and are configured so that rotation of the mouth-shaped portions against one another leads to deformation of at least one of the mouth-shaped portions, so as to break an opening region surrounded by the deformed mouth-shaped portions or adjoining the deformed mouth-shaped portions, particularly at least one internal opening region or the one belonging to the internal mouth-shaped portion. 
     In particular, neck-shaped mouth-shaped portions may be configured such that, by pushing them inside one another and rotating them against one another, preferably about an, in particular, common central axis, an outer side of an inwardly arranged mouth-shaped portion comes into contact with the inner side of an outwardly arranged mouth-shaped portion, so that a force thus generated re-shapes or deforms one or both of the mouth-shaped portions. In particular, the mouth-shaped portions may each be oval in cross-section and/or may be pushed inside one another in a similar orientation, at least to begin with, in order to bring about (mutual) deformation or re-shaping as rotation takes place. In this way, a longitudinal dimension may be compressed and/or a transverse dimension may be extended, thus causing a tensile fracture, burst, tear and/or detachment of the opening means, preferably at least of the inner connecting arrangement, resulting in the opening. 
     Particularly preferably, the opening region is configured to be bent, pulled and/or stretched by the deformation. In particular, the opening region is formed as a film or sealing film which is configured to tear, when the mouth-shaped portion on which it is arranged or provided is deformed, thereby opening the connecting arrangement. 
     According to a further aspect of the present invention, by bringing the first connecting arrangement and the second connecting arrangement towards each other, first of all only one of the first and second opening regions is broken, particularly by piercing, and the continuous fluidic connection is only produced as the connecting arrangements are brought closer together, by fracture of the other one of the first and second opening regions. 
     There are preferably at least two different possible ways of breaking through the opening regions or frangible points of the different connecting arrangements and thereby carrying out mutual opening of the connecting arrangements. 
     In a first variant, first of all a connecting arrangement is pushed into the other connecting arrangement with its mouth-shaped portion, thereby breaking through the opening region of the other connecting arrangement and then deformation of the pushed-in connecting arrangement is carried out by rotating the connecting arrangements against one another, leading to fracture of their opening regions and as a result producing the continuous fluidic connection. 
     In a second variant a connecting arrangement comprises a severing element with which the opening region of the other connecting arrangement is first of all broken and thus the opening is carried out. Only after this is the mouth-shaped portion of the other connecting arrangement, the opening region of which has already been opened by the severing element, pushed into the mouth-shaped portion of one connecting arrangement, thereby causing fracture of the opening region of the one connecting arrangement. Also, the continuous fluidic connection is formed as a result, by the mutual opening. 
     What is common to both these variants is that a mouth-shaped portion of a connecting arrangement (hereinafter always referred to as the first connecting arrangement) is used to break through an opening region or to open an opening region of another connecting arrangement (hereinafter always referred to as the second connecting arrangement), preferably by pushing into the mouth-shaped portion of this other connecting arrangement. 
     According to another aspect of the present invention which may thus be implemented independently the connecting arrangements can be connected to one another, preferably non-releasably and/or by latching. Preferably the non-releasable connection of the connecting arrangement is made even before the opening of at least one of the first and second connecting arrangements. In particular, the connecting arrangements are configured so that a non-releasable connection first of all has to be made between the connecting arrangements before the continuous fluidic connection can be produced. 
     Preferably, the connecting arrangements have different connecting positions, particularly latching positions or locking stages, with one another. The connecting arrangements are preferably configured to open none or only one of the first and second connecting arrangements on reaching a first connecting position and to provide the continuous fluidic connection and/or the opening of the two connecting arrangements on reaching another, second connecting position. 
     Thus, there may be at least two connecting positions which are assumed one after the other when the connecting arrangements are pushed or fitted one inside the other. At a connecting position which is reached first in time and/or distance, a non-releasable connection is produced between the connecting arrangement and the continuous fluidic connection is only produced at the second connecting position. This advantageously prevents the connecting arrangements from being separated from one another again after one or both of the connecting arrangements have been opened. In this way, leaks and/or contamination can be prevented. 
     The connecting system is preferably self-sealing as a result of the formation of the fluidic connection. 
     Preferably, the formation of the fluidic connection with the proposed connecting system thus particularly provides a fluidic passage which is sealed off from the environment. 
     To form the seal, preferably at least one opening region acts as a seal as a result of or after the formation of the fluidic connection. In particular, it may be provided that the second connecting arrangement comprises an opening region which acts as a seal, sealing lip or the like at least at the edges when it has been pierced with the mouth-shaped portion of the first connecting arrangement. Alternatively or additionally, however, another seal, particularly a sealing ring or a sealing lip, may be provided. 
     In another aspect which may thus be implemented independently, the present invention relates to a container system having containers, particularly bottles, each with a removal opening, particularly a septum, which are additionally configured to provide a fluidic connection independently of the removal openings. For this purpose, a connecting arrangement is provided, in particular, preferably on the sides remote from the removal opening. For the fluidic connection of a container, in addition to a removal opening or removal device such as a septum, a rotary closure or some other, preferably resealable, closure, it has proved particularly advantageous to provide the connecting arrangement at another position, particularly, in the case of a bottle, on the opposite end from the neck of the bottle. This makes it possible to produce the continuous fluidic connection with the proposed connecting system, without affecting the function of the removal opening. The containers in this case advantageously remain suitable for use individually and separately from one another. 
     In another aspect which may thus be implemented independently, the present invention relates to a container system with the proposed connecting system, in which a first container comprises the first connecting arrangement and a second container comprises the second connecting arrangement of the proposed connecting system. It is particularly preferable that at least one of the containers comprises a removal opening and, at an end remote from or opposite to the removal opening, the connecting arrangement of the proposed connecting system. In this way, the containers can be fluidically connected by means of the proposed connecting system, particularly for mixing the substances, while a, for example standardized, removal opening is neither blocked nor otherwise affected. 
     The first and the second container preferably each comprise a removal opening and, at an end remote from or opposite to the removal opening, particularly on the respective base of the bottle, one of the proposed connecting arrangements. As a result, the containers can be fluidically connected to one another at the end remote from the removal opening by means of the proposed connecting system. 
     By the formation of the fluidic connection, a new combined container is preferably obtained with a combined capacity amounting to the capacities of both containers and/or with a total of two removal openings. This has the advantage that the containers can theoretically also be used separately from one another with the respective removal openings, but the contents of the containers may also be combined and mixed together by forming a continuous fluidic connection between the containers with the proposed connecting system. 
     The container system may also comprise at least one container which comprises the first connecting arrangement at a first end and the other, second connecting arrangement at a second, other, particularly opposite end. The two connecting arrangements are each configured to form a fluidic connection. The container may have, form and/or enclose a volume in which preferably a substance is or can be arranged. This advantageously makes it possible to join more than two containers together fluidically or to mix more than two different substances. For this purpose, the container comprises the two connecting arrangements, so that another container can be fluidically connected at both ends by means of the proposed connecting system. This container preferably forms an adapter between other containers of the container system, but may also be used with only one further container in order to provide a fluidic connection between them and/or may also be produced separately and/or form an independent aspect of the invention. 
     In another aspect which may thus be implemented independently, the present invention relates to the use of the proposed container system, wherein a first container comprises a first substance, particularly a first vaccine against a first disease, wherein a second container comprises a second substance, particularly a second vaccine against a second disease different from the first, wherein the containers in each case comprise a removal opening and in each case comprise, in addition to the respective removal opening, a connecting arrangement for providing a fluidic connection between the containers, for the preparation of a mixture of substances, particularly for the preparation of a combined vaccine for simultaneous immunization against different diseases, wherein the containers are fluidically connected to one another by means of the connecting arrangements, so that the substances are mixed together, and particularly form the combined vaccine. 
     The proposed container system is particularly preferably used for the combined administration of medicaments. In particular, it is possible to store vaccines which are not stable in the long term with one another in separate containers and to connect these containers fluidically by means of the proposed connecting system before use, thus enabling a rapid and efficient formation of a mixture, without affecting removal openings such as septa. Alternatively, the respective vaccines may also be used separately from one another through the removal openings, if no fluidic connection has been formed by means of the connecting system. 
     Containers or bottles and/or connecting arrangements in the sense of the present invention are preferably at least substantially dimensionally stable, rigid or semi-rigid and/or at least substantially formed from plastics material, or plastics material comprising, in particular, polyethylene, HD-PE, LD-PE or polypropylene. 
     A “bottle” in the sense of the present invention is preferably a closable container for transporting and storing fluids, particularly liquids, gases and pourable solids such as powders. A bottle in the sense of the present invention preferably has a diameter which is smaller than its height. A bottle in the sense of the present invention preferably has an at least substantially conically tapering end, also referred to as the neck of the bottle. The neck of the bottle preferably ends in an opening which is, in particular, round, closable and openable for the removal of its contents, also referred to as the removal opening. Bottles in the sense of the present invention are preferably narrow-necked bottles and/or vials. In narrow-necked bottles the diameter or the internal width of the removal opening is less than the average internal diameter of the storage space formed by the bottle, preferably less than 70%, particularly less than 50%. However, other solutions are also possible here. 
     A “connecting arrangement” in the sense of the present invention is preferably a device which is configured to provide the fluidic connection and, preferably, to provide a mechanical connection while forming the fluidic connection. In particular, it is a fluid coupling, a flange, a coupling member, an attachment member, a plug connection, a male and/or female connector, particularly a plug connector, or a part thereof. 
     A “connecting arrangement” in the sense of the present invention may be a portion/region of a container, particularly a bottle, or the connecting arrangement is (in each case) connected to a container, particularly by material, frictional and/or interlocking connection. Particularly preferably the connecting arrangement is at least partially formed by or in one piece with the container or the bottle. Alternatively or additionally the connecting arrangement adjoins a container or a bottle or is otherwise suitable for fluidically attaching or connecting the interior of the container or the bottle. 
     A connecting arrangement is preferably “fluidically sealed”, in the sense of the present invention, when the escape or passage of fluid, particularly liquid, is prevented or when a fluid or liquid barrier prevents the escape or passage of fluid, particularly liquid. 
     Connecting arrangements are “insertable in one another” in the sense of the present invention particularly when a part or portion of one of the connecting arrangements can be arranged inside the other connecting arrangement or a part or portion thereof. In particular, at least a portion of one of the connecting arrangements can be pushed, laid, inserted or otherwise introduced into the other or corresponding connecting arrangement. Connecting arrangements are inserted in one another particularly when they overlap radially at least partially, substantially or completely in relation to a (common) axis of symmetry and/or central axis, or an inner portion of the one connecting arrangement is (completely) surrounded or embraced (radially) by an outer portion of the other connecting arrangement. 
     An “axial movement” along a common axis in the sense of the present invention is preferably a movement which is non-helical, non-rotational, at least substantially or solely linear and/or solely axial and/or a movement which does not require a complete rotation or revolution. The connecting arrangements are preferably adapted to be fitted into one another, inserted in one another and/or fitted together in an at least substantially linear manner to produce the non-releasable and/or fluidic connection. 
     “Opening” in the sense of the present invention particularly denotes providing access to the interior of a container or a bottle or the volume contained by a container or bottle, by forming an opening, an orifice, a passage, a hole or the like, particularly so that a fluid, particularly a liquid, can enter and/or leave. 
     An “opening region” in the sense of the present invention is in particular a region which is configured for opening, i.e. is constructed so as to form an opening, an orifice, a passage, a hole or the like or fluidic access for the interior or for the volume contained by a container. The opening region is preferably fluidically closed and fluidically openable. It may be a closed off hole, a closed and openable wall orifice, a closed and openable passage, a closed and openable closure or the like. 
     A “film-shaped opening region” is preferably a portion which is particularly of thin-walled or flat construction to form an opening. A film-shaped opening region is preferably an opening/region which is sealed or closed off by a film-shaped, membrane-shaped, flat, thin, breakable and/or fragile structure. 
     “Pierceable” in the sense of the present invention is, in particular, a structure which can be broken through or perforated by means of an object, particularly a point, so that a connection can be made from one (flat) side to the opposite side. The piercing preferably produces an opening. In particular, a pierceable opening region is destroyed on piercing and permanently opened thereby. 
     “Sealing” in the sense of the present invention indicates in particular that the escape and/or ingress of substances is prevented by a barrier. 
     “Self-sealing” in the sense of the present invention denotes in particular that a sealing action is produced without separate aids, with intrinsic means and/or automatically, fully automatically, coincidentally or without the need for any separate steps. 
     “Sterile self-sealing” in the sense of the present invention denotes, in particular, self-sealing, thereby forming a barrier against the ingress of germs such as bacteria or viruses, so as to at least substantially prevent the ingress and/or escape of bacteria. In particular, the seal, the sealing clearance and/or contact pressure are designed so that any leaks that may potentially remain have a maximum cross section which blocks the passage of germs such as bacteria or viruses. 
     “Fluid-tight” in the sense of the present invention is in particular a seal which at least substantially prevents the entrance or exit of fluids, particularly liquids. 
     “Gas-tight” in the sense of the present invention is, in particular, a seal which at least substantially prevents the entrance or exit of gases. 
     A “material construction” in the sense of the present invention denotes in particular a composition and/or a structure and/or a morphology and/or an arrangement of different structures, different materials or the like. 
     A “laminar construction”, also a sandwich construction, multi-layered construction, particularly a composite construction, a composite material and/or a laminated compound material in the sense of the present invention denotes in particular a structure comprising different layers which are preferably joined together and/or adjoining one another, can be logically sub-divided or delimited from one another, are arranged with their flat sides facing one another or arranged against one another, comprising flat elements or portions which can be differentiated by their physical or chemical properties. 
     “At the edges” in the sense of the present invention or an “edge portion” in the sense of the present invention is in particular a region spaced from a center, middle or center of gravity, or a region which has an edge, a margin, an end or a boundary, adjoins the latter or faces the latter. In particular, it is a portion of a preferably flat structure at its circumferential edge, in particular of an encircling or annular shape or the like. 
     A “central portion” in the sense of the present invention is, in particular, a portion at a spacing from an end, edge and/or margin, and/or comprises, encompasses or extends around a center, a middle point or center of gravity. 
     “Destroying the opening region” in the sense of the present invention denotes in particular the irreversible changing of the opening region, thereby impacting its previous function as a seal, wall, sealing member and/or closure or so that the previous function is no longer performed, particularly as a result of machining, shaping, deformation, tearing, separation or by some other method. The opening region may be opened and/or the fluidic connection may be produced thereby. 
     “Cutting through the opening region” in the sense of the present invention denotes in particular severing the material of the opening region from one side to another, particularly an opposite side, and/or dividing them and/or severing them by cutting, shearing, piercing or some other method. 
     “Remaining intact” in the sense of the present invention denotes in particular the maintenance of a previously existing function. An intact opening region has and retains, in particular, the function or functions of closing off, sealing and/or forming a barrier against the ingress and/or escape of germs, fluids, liquids, gases or the like. 
     A fluid for the purposes of the present invention is preferably a flowable substance. A fluid is particularly flowable such that it is able to pass through a fluidic connection. In particular, a fluid for the purposes of the present invention is a liquid, a suspension, a flowable solid, such as a powdered or granulated material, and/or a gas in liquid or gaseous form. Particularly preferably, at least one of the substances is liquid, particularly both or at least two substances. 
     A “fluidic connection” in the sense of the present invention is preferably an arrangement configured for the passage of a fluid, particularly a liquid, a gas or a flowable solid. In particular it is a transit region, a passage or channel. 
     A “fluidic passage” in the sense of the present invention is in particular a means which is configured for the passage of a fluid, particularly a liquid, a gas or a flowable solid. In particular, it is a transit region, a connection or a channel which is preferably (tightly) sealed off from the environment or a side remote from the passage on a wall that forms the passage. 
     Preferably, an opening region in the sense of the present invention is “brittle” if, particularly on account of its composition and/or construction, it is suitable for and designed to tear close to its elastic limit without or with very little plastic deformation (brittle facture). In particular, the opening region has an elastic limit of less than 200 N/mm 2  and/or a tensile strength of less than 100 N/mm 2 , preferably less than 60 N/mm 2  and/or a quotient of elastic limit and tensile strength of less than 1, preferably less than 0.7 or 0.5. This can be achieved in particular by structuring and/or combining, joining or laminating different materials. The opening region may be formed by a laminate of several films, of which preferably one film contains aluminium or consists of aluminium or is metallic. Particularly preferably, the opening region is at least partly metallic. Preferably, the opening region is formed with or from a composite material which preferably has a preferably flat or film-shaped layer of aluminium. 
     An “unstable opening region” in the sense of the present invention is preferably a region which is mechanically less stable than the parts surrounding it and/or which can be destroyed manually or by the application of force, particularly in the manner of a frangible point. 
     “Outside the opening region” in the sense of the present invention means that this is a region or portion which is separate from the opening region but is preferably directly or indirectly adjacent to the opening region, particularly such that deformation in this region causes stretching of the opening region. 
     “Deformable” in the sense of the present invention is preferably elastic or plastic deformability. The connecting arrangement(s) or mouth-shaped portions are preferably elastically deformable, thus causing plastic/irreversible deformation of the opening region. The connecting arrangement(s) or mouth-shaped portions may, however, also be plastically deformed/deformable. 
     Parts or portions are said to “corresponding to one another” in the sense of the present invention particularly when they are of similar and/or complementary construction to one another, when they fit into one another, resemble one another, are arranged similarly, have similarly oriented structures of similar shape and/or are configured to interact with one another in order to produce a function or effect. 
     “Rotating relative to one another” in the sense of the present invention denotes in particular a rotary movement of a part, preferably a connecting arrangement or a container or a bottle with a connecting arrangement, relative to another part, preferably another connecting arrangement or another container or another bottle. 
     “Rotating against one another” in the sense of the present invention denotes in particular a rotary movement of two parts, preferably a connecting arrangement or a container or a bottle with a connecting arrangement, relative to another part, preferably another connecting arrangement or another container or another bottle, preferably in different or opposite directions of rotation. 
     A “mouth-shaped portion” in the sense of the present invention is in particular a portion or part which comprises or forms an opening, an opening edge, a mouth or a neck, preferably with an opening at its end, or some other tubular portion or a passage with a radially surrounding wall which terminates in an opening, which is preferably open at its end and/or forms an opening at least one end. 
     In the sense of the present invention the term “thin walled” denotes in particular a structure which is flat or planar in cross section with a wall thickness on average less than 2 mm, 1.5 mm, 1 mm and/or less than 0.5 mm or 0.3 mm, particularly preferably less than 200 μm, particularly less than 150 μm. 
     A “closure device” in the sense of the present invention is preferably a part of, or at least substantially forms, an opening region. The closure device here is, in particular, a flat or planar arrangement or closure plate. Thus, a closure device has, in particular, a material thickness that exceeds its longitudinal extent, preferably by a factor of at least 2, 3, 4 or 5. 
     The closure device is preferably formed in one piece, particularly in one piece with the frangible point, particularly the thin point. The closure device together with the frangible point may form an opening region or a part thereof. Preferably, the frangible point forms the film-shaped, brittle and/or unstable part of the opening region or renders the opening region film-shaped, brittle and/or unstable. For this reason, the frangible point is preferably sufficiently fragile to form an opening by tearing under mechanical load. 
     The connecting arrangement is preferably formed from plastics, particularly a thermoplastic material, particularly by injection molding. The opening region is preferably predominantly formed by the closure device, particularly over more than 70%, 80%, 90% or 95% of its area. Thus, compared with the surface area of the closure device, the frangible point takes up an area of less than 10%, particularly less than 5%. 
     The closure device may be S-shaped in cross-section longitudinally of the main dimension. The closure device may have ribs or other reinforcing elements to stiffen it. The closure device is preferably sufficiently stable or rigid that it cannot be deformed, or can only be deformed to an insignificant degree, by the frangible point. The result of this is that a force acting on the frangible point does not deform the closure device or deforms it only insignificantly, particularly by compression, thus ensuring that the frangible point breaks or tears more easily. 
     A “frangible point”, particularly a thin point, in the sense of the present invention is preferably a film-shaped, brittle and/or instable or fragile area or opening region or a film-shaped, brittle and/or unstable or fragile part of the opening region. The frangible point can be a predetermined breaking point. It is not limit to a point but can also be a frangible line, frangible area, predetermined breaking line and/or predetermined breaking area. 
     The frangible point is preferably embodied and designed to be broken or torn by mechanical stress in order to form an opening. In particular, the frangible point interacts with the closure device, while the frangible point can be tensioned relative to the closure device in such a way that the resulting tensions, shear forces and the like lead to breakage of the frangible point. The frangible point thus is or forms, in particular, a weakened point or a portion with a mechanically weakened structure compared with surrounding or adjacent areas. 
     The frangible point is preferably provided completely or partly circumferentially at or within the mouth-shaped portion or holding portion. The frangible point may be in the shape of a bead or web. In particular, the frangible point forms a connecting strip to the closure device, particularly from the holding portion or mouth-shaped portion. 
     A “chamber” in the sense of the present invention is preferably a structure or volume which is tightly sealed or sealable in all directions. The chamber may, however, be openable in principle, for example by a connecting arrangement or by opening a sealing arrangement or the like. 
     A “volume” or “volume formed” in the sense of the present invention preferably denotes a region or a (partial) chamber which is at least substantially or entirely surrounded. The term “volume” may thus be replaced by the term chamber or partial chamber, if required. Moreover, a distinction is made between an inner volume and an outer volume; preferably, this is functionally intended to convey that the inner volume can be reached by passing through the outer volume. Preferably, the outer volume surrounds the inner volume. However, this is not absolutely essential, as in other embodiments the outer volume may form an antechamber to the inner volume. Preferably, the outer volume forms an outwardly sealed antechamber, while the inner volume is adjacent to the outer volume and is sealed off from it, so that the outer volume shields the inner volume from the environment. 
     A “container blank” in the sense of the present invention is preferably a tubular structure with at least two openings, one opening being or forming a removal opening for later opening and/or closing or filling and/or removal. Another opening is of a temporary nature and is sealed off during the manufacturing process of the container, particularly preferably by the leaktight use or incorporation of a connecting arrangement. The connecting arrangement as such can then form part of the container and enable later opening of the container in the region. 
     A container blank in the sense of the present invention comprises the opening for the insertion or fitting of a connecting arrangement, preferably on a side which is opposite or remote from the removal opening. However, other solutions are also possible. In addition, a container blank may also comprise only one opening for insertion or fitting of the connecting arrangement. In this case, the container obtained after assembly has only one opening in the form of the opening region of the connecting arrangement. The container blank preferably comprises a bottle-shaped site which has an at least substantially conically tapering portion or shoulder region which transitions into a bottle neck. The bottle neck then preferably forms, or comprises, the removal opening. 
     A “sealing portion” in the sense of the present invention is preferably a region which is configured and/or arranged for sealing abutment. In particular, it is a sealing lip, a sealing strip or the like. A sealing portion may comprise a sealing surface which is formed by a surface region of the sealing portion and provides the direct sealing effect. In particular, a sealing effect is achieved by means of sealing surfaces bearing directly on one another. For this purpose, the sealing surfaces preferably bear on one another under tension or pressure, for example in the form of a press fit or the like. The sealing surfaces are preferably formed by the material of the sealing portion or the surface of the sealing portion. However, there are also other possibilities, for example, using seals in the region of the sealing portion. 
     A “support portion” in the sense of the present invention preferably interacts with an opening region or a frangible point such that opening of the opening region or breaking or tearing of the frangible point, by mixed-mechanical support, support from below, particularly acting as a bearing or counter-bearing, is avoided. In particular, this is thus a device which diverts or keeps mechanical stress away from fragile, unstable areas, so as to impede or prevent accidental opening. The support portion is particularly configured to relieve stress from the frangible point. 
     A “securing device” in the sense of the present invention is preferably a means for preventing movements, particularly relative movements of connecting arrangements and/or containers, or other actuations which would or could lead to the opening of an opening region. In particular, it is a securing ring or the like, for blocking a, preferably axial, movement of connecting arrangements to one another and to enable such movement during actuation or removal. The securing device preferably comprises a blocking part which, as a working part or working portion of the securing device, is directly responsible for a blockade, particularly of a movement, being implemented or removed. 
     A “guide device” in the sense of the present invention is preferably a mechanism or a part thereof which guides a relative movement of connecting arrangements to one another, particularly bayonet-shaped. This preferably enables a bayonet connection to be obtained. A bayonet connection, also known as a bayonet closure, preferably is a mechanical connection of two at least substantially cylindrical and/or rotationally symmetrical parts, particularly rotationally symmetrical with respect to a central axis or axis of symmetry. 
     The connection is produced by means of the guide devices by a pushing in and turning movement. Parts are inserted axially in one another and after being pushed in axially until they reach a stop they are rotated relative to one another, thus producing an interlockingly engaging blockade in the axial direction. This preferably produces the fluidic connection. 
     A first guide device for this purpose is preferably a slot, a groove or other guide device with an at least substantially right-angled configuration, beginning with a part that extends axially or parallel to the central axis or axis of symmetry, and an adjoining part which extends at least substantially at right-angles to the previous direction. The portion that follows the axially extending portion thus extends preferably at least substantially in a plane perpendicular to the central axis or axis of symmetry. Another or second guide device, and/or guide device corresponding to the first, is preferably a button, peg, strip or other part corresponding to the other guide device, thus corresponding particularly to the groove, slot or the like. Overall, the guide devices thus preferably form a sliding guide. 
     The containers are preferably produced separately from one another for the provision of the fluidic connection. This enables them to be universally applicable. 
     The aspects of the present invention mentioned above and described in the following specific description may also be implemented and advantageous individually and in various combinations. 
     Further details, advantages and properties of the present invention will become apparent from the following description of preferred embodiments in conjunction with the accompanying drawings. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG.  1    shows a longitudinal section through a container system with the proposed connecting system and with the fluidic connection made; 
         FIG.  2    shows a longitudinal section through the proposed connecting system in a first embodiment in a starting position; 
         FIG.  3    shows a longitudinal section through the proposed connecting system of the first embodiment in a first connecting position; 
         FIG.  4    shows a longitudinal section through a proposed connecting system of the first embodiment in a second connecting position; 
         FIG.  5    shows a longitudinal section through a proposed connecting system in a second embodiment in a starting position; 
         FIG.  6    shows a longitudinal section through the proposed connecting system in the second embodiment in a first connecting position; 
         FIG.  7    shows a longitudinal section through the proposed connecting system in the second embodiment in a second connecting position with the connecting arrangements oriented with one another; 
         FIG.  8    shows a longitudinal section through the proposed connecting system in the second embodiment in the second connecting position with the connecting arrangements rotated relative to one another about a common axis; 
         FIG.  9    shows a schematic plan view of a first container with a first connecting arrangement for the proposed connecting system of the second embodiment; 
         FIG.  10    shows a schematic plan view of a second container with a second connecting arrangement for the proposed connecting system of the second embodiment; 
         FIG.  11    shows a schematic cross-section through the proposed connecting system in the second embodiment along the section line XI-XI from  FIG.  7   ; 
         FIG.  12    shows a schematic cross-section through the proposed connecting system in the second embodiment after partial rotation of the connecting arrangements relative to one another; 
         FIG.  13    shows a schematic cross-section through the proposed connecting system in the second embodiment along the section line XIII-XIII from  FIG.  8   ; 
         FIG.  14    shows a schematic longitudinal section through a container with connecting arrangements according to the first embodiment on opposite sides; 
         FIG.  15    shows a perspective view of a container with a second connecting arrangement of the proposed connecting system in the first embodiment; 
         FIG.  16    shows a schematic longitudinal section through the proposed container system with the proposed connecting system according to the first embodiment in a transporting configuration; 
         FIG.  17    shows a schematic longitudinal section through a first container with a first connecting arrangement covered in sterile or sterilizable manner; 
         FIG.  18    shows a schematic longitudinal section through the first container according to  FIG.  17    with the cover device removed; 
         FIG.  19    shows a schematic longitudinal section through the first container held like a foot in the cover device according to  FIG.  17   ; 
         FIG.  20    shows a schematic longitudinal section through the second container with the closure partially removed; 
         FIG.  21    shows a schematic longitudinal section through the proposed container system, indicating the direction of movement for providing the fluidic connection with the proposed connecting system; 
         FIG.  22    shows a schematic longitudinal section through a container system according to a further embodiment in the connected state; 
         FIG.  23    shows a schematic longitudinal section through a container of the container system according to  FIG.  22    in the initial state; 
         FIG.  24    shows a magnified detail of the schematic longitudinal section through a container from  FIG.  23   ; 
         FIG.  25    shows a schematic longitudinal section through the container according to  FIG.  23    with the cover device removed; 
         FIG.  26    shows a perspective view of the container according to  FIG.  23    looking at the connecting arrangement thereof; 
         FIG.  27    shows a schematic longitudinal section through the other container of the container system according to  FIG.  22    in the initial state; 
         FIG.  28    shows a magnified detail of the schematic longitudinal section through a container from  FIG.  27   ; 
         FIG.  29    shows a schematic longitudinal section through the container according to  FIG.  27    with the cover device removed; 
         FIG.  30    shows a perspective view of the container according to  FIG.  27    looking at the connecting arrangement thereof; 
         FIG.  31    shows a schematic longitudinal section through a container system according to  FIG.  22    in the initial state; 
         FIG.  32    shows a detail of a schematic longitudinal section through the container system according to  FIG.  22    in a first connecting position; 
         FIG.  33    shows a detail of a schematic longitudinal section through the container system according to  FIG.  22    in a second connecting position; 
         FIG.  34    shows a detail of a schematic longitudinal section through the container system according to  FIG.  22    in a third connecting position; 
         FIG.  35    shows a schematic longitudinal section through a container system with a proposed securing device in an initial position; 
         FIG.  36    shows a detail of a schematic longitudinal section through the container system according to  FIG.  35    with the securing device actuated; 
         FIG.  37    shows a detail of a schematic longitudinal section through the container system according to  FIG.  35    in a connecting position; 
         FIG.  38    shows a perspective view of the securing device from the embodiment according to  FIG.  35    in the initial position; 
         FIG.  39    shows a schematic longitudinal section through a container system with a proposed securing device according to a second embodiment in an initial position; 
         FIG.  40    shows a detail of a schematic longitudinal section through the container system according to  FIG.  39    with the securing device actuated; 
         FIG.  41    shows a detail of a schematic longitudinal section through the container system according to  FIG.  39    in a connecting position; and 
         FIG.  42    shows a perspective view of the securing device from the embodiment according to  FIG.  39    in the initial position. 
     
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     In the following description of preferred embodiments by reference to the drawings, the same or corresponding reference numerals (with or without an apostrophe) have been used for the same or similar components or parts, where similar or identical advantages and properties may be achieved even if the associated description has not been repeated. 
       FIG.  1    shows in schematic section a proposed container system B with a first container B 1  and a second container B 2 . 
     The container system B preferably comprises a proposed connecting system  1 . The connecting system  1  is preferably configured to produce a fluidic connection  2 , preferably between the first container B 1  and the second container B 2  of the container system B. 
     The connecting system  1  preferably comprises a number of connecting arrangements  3 A,  3 B, particularly a first connecting arrangement  3 A which is associated with a first container B 1  of the container system B and/or a second connecting arrangement  3 B which is associated with the second container B 2  of the container system B. Preferably, the first container B 1  comprises the first connecting arrangement  3 A and the second container B 2  comprises the second connecting arrangement  3 B or vice-versa. 
     The containers B 1 , B 2  are preferably used for storing substances S 1 , S 2 , particularly for storing a first fluid and a second fluid and/or different vaccines. In particular, the containers B 1 , B 2  are wholly or partly filled with one or more different substances S 1 , S 2  or vaccines. Alternatively or additionally the container or containers B 1 , B 2  may also hold and/or store other substances S 1 , S 2 , preferably a solid. It is possible for only one substance S 1 , S 2  to be a fluid, particularly a liquid. The fluid substance S 1 , S 2  may be configured to form a solution or a suspension with the other substance S 1 , S 2 . 
     The proposed container system B is preferably used to prepare a medicament, particularly a combined medicament, combined vaccine or the like. However, there are other possible and advantageous applications for the proposed container system B. 
     Preferably, the first container B 1  comprises a removal opening E 1  and/or the second container B 2  comprises a removal opening E 2 . Particularly preferably, both or at least two containers B 1 , B 2  of the proposed container system B each comprise a removal opening E 1 , E 2 . 
     A removal opening E 1 , E 2  in the sense of the present invention is preferably configured to dispense or to make it possible to remove the contents of the respective container B 1 , B 2 . 
     At least one and preferably several or all of the removal openings E 1 , E 2  are preferably repeatedly useable, utilizable several times, re-sealable, re-usable and/or comprise a closure element V 1 , V 2  which preferably allows opening and closing for the purpose of stepwise removal. This may be achieved by means of a septum. 
     Preferably, the removal openings E 1 , E 2  are closed or closable and/or are primary means for removing substance S 1 , S 2  from the containers B 1 , B 2 . 
     In the embodiment shown, preferably at least one of the removal openings E 1 , E 2  and particularly both removal openings E 1 , E 2  are closed off by so-called septa. A septum is a device with a rubber-shaped closure element V 1 , V 2 , particularly a rubber stopper or injection stopper, which is suitable for piercing by means of an injection needle for removal of its contents, the septum automatically closing the (respective) removal opening E 1 , E 2  by elastic resilience after the injection needle has been removed. A septum, also referred to as a piercing membrane, preferably has a thin area, particularly in the center, this thin area being suitable for piercing in order to take up injection liquid using an injection needle. The injection stopper or the septum is preferably secured to the neck of the bottle or the removal opening E 1 , E 2  by means of a flanged cap, preferably made of aluminium. 
     Preferably, one, both or all the containers B 1 , B 2  are (each) injection ampoules or vials, for example, so-called multi-dose containers, particularly for vaccinating a number of animals with one dose each. 
     In the containers B 1 , B 2 , substances S 1 , S 2  in the form of powdered medicaments, solutions or suspensions or vaccines may be transferred in this form. 
     The containers B 1 , B 2  may (each) have a capacity of more than 10 ml, preferably more than 50 ml, 100 ml or 200 ml and/or less than 2 litres, preferably less than 1.5 litres or 1 litre, particularly less than 750 ml (each or after connection). 
     As shown in  FIG.  1   , the closure element V 1 , V 2  is preferably sealingly connected to the respective removal opening E 1 , E 2 , preferably pressed on, particularly by means of a pressing ring or compression ring or a flanged cap. However, other solutions are also possible here, for example an adhesive bond, welded joint, a connection produced by injection molding or the like. 
     It is certainly preferable that the containers B 1 , B 2  of the proposed container system B should each have a removal opening E 1 , E 2 , but not all the containers B 1 , B 2  of the container system B must have a removal opening E 1 , E 2 . 
     Advantageously, the use of removal openings E 1 , E 2  on a number of containers B 1 , B 2  makes it possible to use the respective substance S 1 , S 2  from the respective container B 1 , B 2  independently of the use of the connecting system Advantageously, the container system B therefore allows both separate use of the containers B 1 , B 2  and also their use in conjunction with the fluidic connection  2  provided by the connecting system  1 . 
     The containers B 1 , B 2  are preferably fluidically connectable to one another so that the fluidic connection  2  between the volumes formed or held by the containers B 1 , B 2  results in a joint interior being formed by the containers B 1 , B 2  connected by the connecting system  1 . The joint interior is particularly characterized in that the continuous fluidic connection  2  has a hydraulic cross section of more than 2 square millimetres, preferably more than 5 or 10 square millimetres, particularly more than 1, 2 or 3 square centimetres, or there is no constriction between the containers B 1 , B 2 , once the fluidic connection  2  has been made, which falls below such a hydraulic cross section or wherein the fluidic connection  2  has at least such a hydraulic cross section. 
     The container or containers B 1 , B 2  is or are preferably configured as bottles. Particularly preferably, the containers B 1 , B 2  (each) comprise a bottle neck F 1 , F 2  which forms the removal openings E 1 , E 2  or is adjacent thereto. A bottle neck F 1 , F 2  may, starting from a terminal edge or mouth of the removal opening E 1 , E 2 , encompass an enlargement of the (hydraulic) cross section by more than a factor 1.5, particularly by more than a factor 2 or 2.5. However, the removal openings E 1 , E 2  may also be differently constructed. 
     The containers B 1 , B 2  preferably comprise the removal opening E 1 , E 2  and the connecting arrangement  3 A,  3 B at different, opposite, diametrically opposed sides, ends, axial ends and/or in the neck region on the one hand and in the base region on the other hand. In particular, the removal opening E 1 , E 2  is formed by the bottle neck F 1 , F 2  and the connecting arrangement  3 A,  3 B is provided in the base region or at the opposite end from the bottle neck F 1 , F 2 . This has proved advantageous as it ensures that, when the connecting arrangements  3 A,  3 B are used, the removal opening(s) E 1 , E 2  remain(s) accessible and unaffected in its (their) function. 
     The connecting arrangements  3 A,  3 B are preferably not intended for removal but for a one-time or irreversible provision of a durable fluidic connection  2 , or are not reclosable. 
     The present invention is explained by means of the particularly preferred use for connecting to containers B 1 , B 2 , particularly bottles. However, it is possible and advantageous to use the proposed connecting system  1  in other areas as well, for example for fluidically connecting a container B 1 , B 2  to other systems, for example for the rapid removal of the substance S 1 , S 2 . 
       FIG.  2    shows in longitudinal section a proposed connecting system  1  according to the first embodiment in a starting position or in the unconnected state. 
       FIG.  3    shows in longitudinal section the proposed connecting system  1  according to the first embodiment in a first connecting position in which preferably the fluidic connection has not yet been made but one of the opening regions  4 A,  4 B has already been opened. 
       FIG.  4    shows in longitudinal section a proposed connecting system  1  according to the first embodiment in a second connection position in which a fluidic connection  2  is produced. This is the position which is also shown in  FIG.  1   . 
     The proposed connecting system  1  preferably comprises a plurality of connecting arrangements  3 A,  3 B, particularly preferably at least the first connecting arrangement  3 A and the second connecting arrangement  3 B, which are preferably configured to be at least partially complementary to one another or corresponding to one another. 
     The first connecting arrangement  3 A preferably comprises an opening region  4 A. The second connecting arrangement  3 B preferably comprises an opening region  4 B. 
     Preferably, the containers B 1 , B 2  comprise the opening regions  4 A,  4 B or the opening regions  4 A,  4 B form a part of the respective connecting arrangement  3 A,  3 B which is associated with the respective container B 1 , B 2  or forms a part thereof. 
     Preferably, one or both opening regions,  4 A,  4 B are regions or portions of the respective connecting arrangement  3 A,  3 B which are configured to produce the fluidic connection  2  (durably and/or irreversibly), particularly by (irreversible) destruction thereof. For this purpose the opening region or regions  4 A,  4 B may have a (mechanical) weakened area or frangible point or may be configured as a weakened area or frangible point. The opening regions  4 A,  4 B, may be identical, similar or different in construction, particularly with respect to the reduced material and/or the shape of the opening regions  4 A,  4 B. 
     In particular, the opening regions  4 A,  4 B are configured to be (mechanically) destroyed or pierced in order to provide the fluidic connection  2 . For this purpose an opening region  4 A,  4 B according to the present invention may be configured to be destroyed, perforated and/or torn open under mechanical load in order to enable or produce the fluidic connection  2 . 
     In the embodiment shown, the opening regions  4 A,  4 B are formed by film-shaped or membrane-shaped wall portions of the respective connecting arrangement  3 A,  3 B. In particular, one or more of the opening regions  4 A,  4 B is or are sealing films. In principle, the opening regions  4 A,  4 B may, however, be formed by weakening the material that forms the respective connecting arrangement  3 A,  3 B and/or may be formed in one piece with the respective connecting arrangement  3 A,  3 B. 
     The opening regions  4 A,  4 B are preferably configured as wall portions of the (respective) connecting arrangement  3 A,  3 B. The opening regions  4 A,  4 B are preferably regions of low wall thickness which have been weakened in some way by comparison with the adjacent regions. Preferably, the opening regions  4 A,  4 B have a material thickness which is less than a material thickness of the adjacent regions, particularly walls, of the (respective) connecting arrangement  3 A,  3 B. The (respective) opening regions  4 A,  4 B are thus preferably thinner, more film-shaped and/or membrane-shaped by comparison with the adjacent regions. 
     The opening region or regions  4 A,  4 B preferably comprise or comprises one or more frangible points, particularly indentations, thin areas, brittle regions or portions. In particular, the second connecting arrangement  3 B or its opening region  4 B comprises a frangible point corresponding to the mouth-shaped portion  5 A of the first connecting arrangement  3 A. This assists with or favors the destruction or piercing of the opening region  4 B of the second connecting arrangement  3 B, even if, by the use of the mouth-shaped portion  5 A for this purpose, a severing force acting on the opening region  4 B acts or is distributed over a larger area. 
     In the embodiment shown in  FIGS.  2  to  5   , the opening regions  4 A,  4 B are each formed by sealing films which are welded, adhesively bonded, sealed or in some other way tightly connected, particularly in water-tight manner, to the respective connecting arrangement  3 A,  3 B, preferably the mouth-shaped portion  5 A,  5 B thereof. 
     Particularly preferably, the opening regions  4 A,  4 B are formed by a multilayer or laminar material, particularly a plastics/metal film composite or sandwich material. The opening regions  4 A,  4 B, however, may also be embodied differently, for example by the use of several layers and/or a brittle or porous material, so as to have only a limited elasticity, so that even under slight mechanical stress the opening regions  4 A,  4 B are torn or otherwise destroyed. 
     The opening region or regions  4 A,  4 B are preferably configured to tear when mechanically stressed and thereby produce the fluidic connection  2 . Preferably, the opening regions  4 A,  4 B have a material with a modulus of elasticity of more than 2000 N/mm 2 , preferably more than 4000 N/mm 2 , particularly more than 6000 N/mm 2 . Alternatively or additionally, the opening regions  4 A,  4 B may have a tensile strength of less than 100 N/mm 2 , preferably less than 80 N/mm 2 , more particularly less than 60 N/mm 2 . The modulus of elasticity and the tensile strength may be determined according to EN ISO 6892-1, ISO 6892, ASTM E 8, ASTM E 21, DIN 50154, DIN 50125 and/or ISO 527, ASTM D 638. 
     It is also preferable that the opening region or regions should have a material thickness of less than 100 μm, preferably less than 70 μm, particularly less than 50 μm and/or more than 5 μm, particularly more than 10 μm. 
     The first connecting arrangement  3 A,  3 A′ preferably comprises the first, particularly film-shaped, opening regions  4 A,  4 A′ and/or the second connecting arrangement  3 B,  3 B′ preferably comprises a second, particularly film-shaped opening region  4 B,  4 B′. Advantageously, this simultaneously ensures secure closure  14  of the respective connecting arrangements  3 A,  3 A′,  3 B,  3 B′ and reliable and simple opening of the respective opening regions  4 A,  4 A′,  4 B,  4 B′. 
     The first connecting arrangement  3 A,  3 A′ is preferably configured to open the second connecting arrangement  3 B,  3 B′ by piercing or destroying the second opening region  4 B,  4 B′. Alternatively, or additionally the second connecting arrangement  3 B,  3 B′ is preferably configured to open the first connecting arrangement  3 A,  3 A′ by piercing or destroying the first opening region  4 A,  4 A′. Advantageously, the fluidic connection  2  may thus be produced manually or without the use of tools. The interiors of the containers B 1 , B 2 , B 3  are preferably connectable by means of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ without any further aids or tools. 
     Preferably, to produce the fluidic connection  2 , the opening region  4 A,  4 A′,  4 B,  4 B′ of the second connecting arrangement  4 B,  4 B′ may be pierced with the first connecting arrangement  4 A,  4 A′ and preferably the first opening region  4 A,  4 A′ of the first connecting arrangement  3 A,  3 A′ may be pierced with the second connecting arrangement  3 B,  3 B′, particularly a severing element  7  thereof. The fluidic connection  2  may thus be produced by mutual perforation or piercing. 
     The connecting arrangements  3 A,  3 A′,  3 B,  3 B′ preferably have mouth-shaped portions  5 A,  5 A′,  5 B,  5 B′, which are formed such that the mouth-shaped portion  5 A,  5 A′,  5 B,  5 B′ of one of the first and second connecting arrangements  3 A,  3 A′,  3 B,  3 B′ may be aligned with the mouth-shaped portion  5 A,  5 A′,  5 B,  5 B′ of the other one of the first and second connecting arrangements  3 A,  3 A′,  3 B,  3 B′, so that preferably the opening region  4 A,  4 A′,  4 B,  4 B′ of the other one of the first and second connecting arrangements  3 A,  3 A′,  3 B,  3 B′ can be pierced and/or the other one of the first and second connecting arrangements  3 A,  3 A′,  3 B,  3 B′ can be opened. 
     The opening region  4 A preferably comprises the mouth-shaped portion  5 A and/or the opening region  4 B comprises the mouth-shaped portion  5 B. The mouth-shaped portions  5 A,  5 B preferably delimit the opening regions  4 A,  4 B. The mouth-shaped portions  5 A,  5 B may be formed in one piece with and/or as a wall portion of the respective connecting arrangement  4 A,  4 B. Preferably, the mouth-shaped portions  5 A,  5 B have open edges or are formed in the shape of collars or necks, the respective opening region  4 A,  4 B preferably being surrounded or delimited by the respective mouth-shaped portions  5 A,  5 B. The mouth-shaped portions  5 A,  5 B or the open edges thereof preferably adjoin the opening regions  4 A,  4 B or delimit them, or vice-versa. Particularly preferably, an open edge of the respective mouth-shaped portion  5 A,  5 B forms a (circumferential) fixing portion for an opening region  4 A,  4 B which is more particularly film-shaped or formed by a film. 
     The container system B, in another aspect of the present invention which may also be implemented independently, comprises a cover device  6  which is configured to hold one of the containers B 1 , B 2 , particularly to act as a foot for it. Advantageously, the cover device  6  may alternatively or additionally serve for, particularly sterile, covering of one of the containers B 1 , B 2  and/or one of the connecting arrangements  3 A,  3 B. This aspect will be discussed in more detail hereinafter. 
     The connecting arrangement  3 A,  3 B and the method for producing the fluidic connection therewith is explained in more detail hereinafter in a first embodiment illustrated in  FIGS.  2  to  5   . 
     In the first embodiment the first connecting arrangement  3 A is configured for opening the opening region  4 B of the second connecting arrangement  3 B. It is particularly preferable that the mouth-shaped portion  5 A of the first connecting arrangement  3 A should be adapted to be inserted or pushed into the mouth-shaped portion  5 B of the connecting arrangement  3 B such that during the insertion or introduction the opening region  4 B of the second connecting arrangement  3 B is opened. 
     In the embodiment shown, the first connecting arrangement  3 A,  3 A′ or the first mouth-shaped portion  5 A,  5 A′ is a preferably male coupling element and/or the second connecting arrangement  3 B,  3 B′ or the second mouth-shaped portion  5 B,  5 B′ is a, preferably female, coupling element, particularly forming a fluid coupling. 
     In particular, it is provided that one end or an open edge of the mouth-shaped portion  5 A has an outer circumferential edge which can be arranged inside an inner circumferential edge of the mouth-shaped portion  5 B. 
     Preferably, the outer circumferential edge of the mouth-shaped portion  5 A of the first connecting arrangement  3 A corresponds to the inner circumferential edge of the mouth-shaped portion  5 B of the second connecting arrangement  3 B or resembles it, or vice versa. In particular, the mouth-shaped portion  5 A of the first connecting arrangement  3 A comprises, at least laterally or at a transition to the opening region  5 A, an external diameter which is less than an internal diameter of the mouth-shaped portion  5 B of the second connecting arrangement  3 B, preferably at least at a terminal edge or at a transition to the opening region  5 B. In the embodiment shown in  FIGS.  2  to  5   , the mouth-shaped portion  5 A,  5 B is preferably neck-shaped and/or at least substantially round in cross section. 
     Unless otherwise stated, the term cross-section in the sense of the present invention always refers to a section or a sectional representation at right angles to the longitudinal axis or axis of symmetry  9  of the respective container B 1 , B 2  and/or the respective connecting arrangement  3 A,  3 B. 
     The second connecting arrangement  3 B of the first embodiment preferably comprises a severing element  7  which is preferably configured to pierce, sever, cut or generally destroy the opening region  4 A of the first connecting arrangement  3 A. In particular, the severing element  7  comprises or is formed by a piercing device, a point, a blade, a wedge or generally a cutting and/or severing device. 
     The severing element  7  is preferably arranged and/or attached on the opening region  4 B of the second connecting arrangement, particularly directly. The severing element  7  is preferably arranged on an outer side of the second connecting arrangement  3 B or on a side or outer side remote from the interior of the container B 2 . The severing element  7  is preferably arranged so that by bringing the connecting arrangement  3 B of the severing element  7  close to the opening region  4 A of the first connecting arrangement the severing element  7  applies a force to the opening region  4 A which leads to the destruction and opening of the opening region  4 A, preferably without opening or destroying the opening region  4 B of the second connecting arrangement  3 B. 
     In particular, the severing element  7  is a device which concentrates a force acting on the opening region  4 A or distributes a counter-force acting on the second connecting arrangement  3 B or on the opening region  4 A such that the opening region  3 B of the second connecting arrangement  3 B remains intact when the opening region  4 A is opened by being destroyed by the severing element  7 . 
     In a variant (not shown) the severing element  7  is arranged on an inner side of the connecting arrangement, within or inside the interior of the container B 1  or (viewed from outside) arranged behind the opening region  3 B of the second connecting arrangement  3 B. Preferably, the opening region  4 A,  4 A′ of the first connecting arrangement  3 A is destroyed by the severing element  7  as the mouth-shaped portion  5 A is pushed into the mouth-shaped portion  5 B of the second connecting arrangement  3 B. For this purpose the severing element  7  is provided, particularly directly (on the inside or on the side remote from the first connecting arrangement  3 A) behind the opening region  4 B of the second connecting arrangement  3 B. 
     Preferably, the severing element  7  is immovably arranged or fixed on the second connecting arrangement  3 B, particularly (directly) on, in front of or behind the opening region  4 A. 
       FIG.  2    shows the proposed connecting system  1  in a starting position in which the opening regions  4 A,  4 B or the containers B 1 , B 2  are closed or sealed. In particular they are (in each case) bottles or bottle-shaped containers B 1 , B 2 , the bottom opening regions  4 A,  4 B of which are closed in the starting position. 
     As shown by the arrow  8  indicating movement, the first connecting arrangement  3 A and the second connecting arrangement  3 B may be moved towards one another or pushed into one another. For this purpose, the connecting arrangements  3 A,  3 B are preferably moved axially towards one another with respect to a central axis or axis of symmetry  9 . The central axis or axis of symmetry  9  is preferably a central axis or axis of symmetry  9  of the mouth-shaped portion or portions  5 A,  5 B and/or of the opening region or regions  4 A,  4 B and/or of the container or containers B 1 , B 2 . 
     The containers B 1 , B 2 , the connecting arrangements  3 A,  3 B, the opening regions  4 A,  4 B and/or the mouth-shaped portions  5 A,  5 B may thus be formed substantially symmetrically with respect to the central axis or axis of symmetry  9 . An axially symmetrical and/or rotationally symmetrical construction of the mouth-shaped portions  5 A,  5 B is preferred, as this enables the connecting arrangements  3 A,  3 B to be used independently of their rotary position. However, other solutions are also theoretically possible, particularly ones in which the mouth-shaped portions  5 A,  5 B are rotationally asymmetrical or non-round and preferably a guide is provided which is configured to define a rotary position of the connecting arrangements  3 A,  3 B relative to the central axis or axis of symmetry  9 . This will be discussed in more detail in connection with the second embodiment. 
     As can be seen in  FIG.  3   , as the connecting arrangements  3 A,  3 B come closer to one another the severing element  7  is applied to the opening region  4 A, preferably with a point  7 A and by further movement of the connecting arrangements  3 A,  3 B towards one another, pushed through the opening region  4 A. In this way the opening region  4 A is destroyed or the connecting arrangement  3 A and/or the container B 1  is opened. 
     The connecting arrangements  3 A,  3 A′,  3 B,  3 B′ are preferably designed to be separate and/or independent of one another in a starting position (cf. also  FIGS.  16  and  17   ). This advantageously enables common and also separate use of cavities or containers B 1 , B 2 , B 3  which are connected to or connectable with the connecting arrangements  3 A,  3 A′,  3 B,  3 B′. 
     In the starting position, the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ are preferably unconnected or fluidically separated from one another. As a result of the formation of the fluidic connection  2 , the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ move into a connecting position in which the fluidic connection  2  is made. 
     A fluidic connection  2  between the containers B 1 , B 2 , B 3  is preferably produced at least when the volumes or substances S 1 , S 2 , S 3  enclosed by the containers B 1 , B 2 , B 3  are able to be moved between the containers B 1 , B 2 , B 3 , by gravity and/or mixed with one another. 
     The fluidic connection  2  is, in particular, a channel or a passage through which fluid substances S 1 , S 2 , S 3 , particularly liquids, can flow. 
     The connecting arrangements  3 A,  3 A′,  3 B,  3 B′ are preferably usable only once and/or are irreversibly openable; the fluidic connection  2  is preferably permanent and/or irreversible. 
     The connecting system  1  is preferably configured for the provision of a non-releasable or non-separable connection, particularly with the non-separable connection taking place even before at least one of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ has been opened. This prevents substances from escaping and advantageously prevents a partial mixing process from taking place. 
     The connecting arrangements  3 A,  3 A′,  3 B,  3 B′ preferably comprise securing devices  10 A,  10 B for producing the non-releasable connection, which produce a non-releasable connection between the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ as a result of being fitted into one another and/or passed through one another by axial movement along their shared axis. In particular, the securing devices  10 A,  10 B comprise snap-fit hooks and/or are non-releasable or self-securing by means of snap-fit hooks or a snap-fit hook connection. In this way it is possible to ensure that the connection cannot be undone manually and/or without damage or destruction. 
     The connecting arrangements  3 A,  3 A′,  3 B,  3 B′ can preferably be connected to one another non-releasably or inseparably by interlocking and/or frictional engagement, particularly by latching. In particular, different connecting positions, particularly latching positions, can be achieved by fitting one inside the other and/or inserting one inside the other by axial movement along the common axis. 
     In particular, one of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ comprises a latching means, particularly one or more latching lugs, arranged on portions located axially behind one another. Preferably, the latching means of one of the connecting arrangements are arranged such that one or more complementary latching means of the other connecting arrangement  3 A,  3 A′,  3 B,  3 B′, particularly one or more grooves or undercuts, latch into one another to form an engagement by being fitted into one another and/or inserted in one another with axial movement along the common axis. This enables the non-releasable or inseparable connection or the connecting position to be achieved. 
     The connecting arrangements  3 A,  3 A′,  3 B,  3 B′ are preferably configured so that when a first connecting position is reached the non-releasable or inseparable connection is made and/or none or only one of the first and second connecting arrangements  3 A,  3 A′,  3 B,  3 B′ is or has been opened. The fluidic connection  2  is thus preferably not yet or not entirely formed in the first latching position. 
     When another, second connecting position is reached which is preferably after the first connecting position in location and/or time, the continuous fluidic connection  2  and/or the opening of the two connecting arrangements  3 A,  3 A′,  3 B,  3 B′ is preferably produced. 
     By bringing the first connecting arrangement  3 A,  3 A′ and the second connecting arrangement  3 B,  3 B′ towards one another, preferably first of all only one of the first and second opening regions  4 A,  4 A′,  4 B,  4 B′ is broken, particularly pierced, and only as the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ are brought closer together or subsequently rotated relative to one another or pushed into one another, is the continuous fluidic connection  2  produced by the breakage of the other one of the first and second opening regions  4 A,  4 A′,  4 B,  4 B′. 
     Preferably, the connecting system  1  has a first connecting position in which the connecting arrangements  3 A,  3 B are connected to one another non-releasably, preferably by latching. For this purpose the connecting arrangements  3 A,  3 B may have securing devices  10 A,  10 B corresponding to another which produce a non-releasable connection between the connecting arrangements  3 A,  3 B as the connecting arrangements  3 A,  3 B are brought close together. 
     In the embodiment shown, the securing devices  10 A,  10 B are formed by corresponding or complementary undercuts, latching lugs or the like. In particular, individual latching lugs are formed on one of the connecting arrangements  3 A,  3 B and, in particular, annular beads and/or undercuts are formed on the other of the connecting arrangements  3 A,  3 B, which by co-operating provide a latching connection between the connecting arrangements  3 A,  3 B. 
     Particularly preferably, the securing devices  10 A,  10 B are configured for connecting the connecting arrangement  3 A,  3 B non-releasably with one another in a first connecting position but allowing further movement of the connecting arrangement  3 A,  3 B towards one another. 
     Moreover, the securing devices  10 A,  10 B are preferably configured so as to support a further, second connecting position in which the connecting arrangements  3 A,  3 B are brought more closely together or pushed further into one another than in the first connecting position. Particularly preferably, a plurality of latching positions are provided, in which, in a first latching position, the connecting arrangements  3 A,  3 B are already non-releasably connected to one another. The proposed connecting system  1  is shown in this first connecting position in  FIG.  3   . 
     In the first connecting position, one of the connecting arrangements  3 A,  3 B may already have been opened. Alternatively or additionally, the first connecting position may also be characterized in that a non-releasable connection has indeed been made between the connecting arrangements  3 A,  3 B but none of the opening regions  4 A,  4 B has yet been opened or is being opened. 
     In the embodiment shown in  FIG.  3   , in the first connecting position, the first connecting arrangements  3 A are connected to the second connecting arrangement  3 B in non-releasable manner by latching and the first opening region  4 A has already been opened or destroyed by the severing element  7 . 
       FIG.  4    shows the proposed connecting system  1  in the second connection position, particularly a further latching position, in which the connecting arrangements  3 A,  3 B have been further brought together and/or pushed further inside one another, particularly at least substantially completely, compared with the first connecting position. In the second connecting position the first opening region  4 A of the first connecting arrangement  3 A has been opened by the second connecting arrangement  3 B and furthermore the opening region  4 B of the second connecting arrangement  3 B has been opened by the first connecting arrangement  3 A. 
     In order to open the second connecting arrangement  3 B with or by means of the first connecting arrangement  3 A, preferably the mouth-shaped portion  5 A of the first connecting arrangement  3 A is pushed through the opening region  4 B of the second connecting arrangement  3 B, thereby destroying said opening region  4 B. This is preferably done as the connecting arrangements  3 A,  3 B are moved from the first connecting position into the second connecting position. 
     The securing devices  10 A,  10 B are preferably configured to prevent (axial) movement of the connecting arrangements  3 A,  3 B away from one another, both in the first connecting position and in the second connecting position. Thus it is envisaged, in particular, that the connecting arrangements  3 A,  3 B are movable further into the second connecting position from the first connecting position but not in an opposite direction. It is also preferable that the connecting arrangements  3 A,  3 B in the second connecting position (cf.  FIG.  4   ) cannot be moved back into the first connecting position. 
     Preferably, the connecting arrangements  3 A,  3 B abut on one another, particularly sealingly, in the first connecting position. This prevents substances S 1 , S 2  from escaping. 
     According to an aspect of the present invention which can also be implemented independently, during or as a result of the opening of the opening region  4 B of the second connecting arrangement  3 B by the mouth-shaped portion  5 A of the first connecting arrangement  3 A, a seal is formed relative to the environment. In particular, the opening region  4 B of the second connecting arrangement  3 B forms a sealing system with the mouth-shaped portion  5 B of the second connecting arrangement  3 B. Alternatively or additionally, the mouth-shaped portions  5 A,  5 B may have a sealing action by bearing against one another, while the opening region  4 B acts sealingly or provides a seal, particularly at the edges and/or in the transitional area to the mouth-shaped portion  5 B. However, there are also other possible solutions, for example using an additional or separate rubber seal, sealing lip or the like. 
     The connecting arrangements  3 A,  3 B or the connecting system  1  is or are preferably formed without threads. It has been found that systems known from the prior art which use threads to move a cutting tool in order to open containers are more prone to defects and require greater expense in order to create an opening or fluidic connection. Advantageously, the connecting arrangements  3 A,  3 B of the present connecting system can be connected to one another by a simple linear or axial movement and/or by moving directly towards one another (without the need for any additional rotation through several revolutions relative to one another). This has proved advantageous for rapid and comfortable production of the fluidic connection  2 . 
     In this connection it is also advantageous that the proposed connecting system  1  comprises one or more connecting positions, particularly preferably in the form of latching positions. This has the particular advantage over interlocking threads that a non-releasable connection can be produced between the connecting arrangements  3 A,  3 B. On the other hand, with a threaded connection, dismantling and contamination are possible. 
     Theoretically, however, it is also possible to combine aspects of the present invention with connecting arrangements  3 A,  3 B which are connected or connectable by interlocking threads or in which the fluidic connection  2  can be produced by interlocking threads and a rotational movement relative to one another. 
       FIGS.  5  to  13    hereinafter illustrate a proposed connecting system  1  according to a second embodiment. Only the special features and differences from the embodiments described above will be discussed and therefore the foregoing remarks also apply in a supplementary manner to the second embodiment unless specifically stated to the contrary or obvious to the person of ordinary skill. 
       FIG.  5    shows in a starting position a first connecting arrangement  3 A′ and a second connecting arrangement  3 B′ according to the second embodiment. In the second embodiment, preferably none of the connecting arrangements  3 A′,  3 B′ has a severing element. In particular, the connecting system  1  according to the second embodiment is free from cutting tools, severing mechanisms and/or free from sharp edged projections or portions for opening. 
     In the second embodiment, mouth-shaped portions  5 A′ and  5 B′ of the connecting arrangement  3 A′,  3 B′ are preferably configured to be rotationally non-symmetrical or non-round, non-circular or oval with respect to the central axis or axis of symmetry  9 . Preferably, the mouth-shaped portions  5 A,  5 B are configured to correspond to one another and/or to be similar in relation to a circumferential line, so that they can be arranged one inside the other and/or one can be pushed into one another. Moreover, for supplementary information, reference may be made to the explanations of the mouth-shaped portions  5 A,  5 B in the first embodiment. 
       FIG.  6    shows the connecting arrangements  3 A′,  3 B′ in the first connecting position in which they are connected to one another, preferably non-releasably. For this, the securing devices  10 A,  10 B may be used as explained hereinbefore. 
     The connecting mean  3 A′,  3   b ′ preferably comprise opening regions  4 A′,  4 B′ which correspond to or resemble the opening region in  4 A,  4 B of the first embodiment. In the first connecting position according to  FIG.  6   , the opening regions  4 A′,  4 B′ abut on one another or are directly adjacent to one another. Alternatively, in the first connecting position, the opening region  4 B′ of the second connecting arrangement  3 B′ may, however, also already have been opened, as explained hereinafter in connection with  FIG.  7   . 
     For opening or penetrating the second opening region  4 B′, the mouth-shaped portion  5 A′ of the first connecting arrangement  3 A′ is pressed through the opening region  4 B′ of the second connecting arrangement  3 B′ as already explained in connection with the opening of the opening region  4 B of the first embodiment. Preferably, the opening region  4 B′, particularly a sealing film or a film-shaped portion of the second connecting arrangement  3 B′ is destroyed or opened, particularly by pushing part of the first connecting arrangement  3 A′ through the opening region  4 B′ so that the opening region  4 B′ is opened or the film or the film-shaped portion which forms the opening region  4 B′ is pierced or destroyed. The result is shown in  FIG.  7   , in which, as a result of reaching the second connecting position, the second connecting arrangement  3 B has been opened in the manner described. 
     By contrast with the first embodiment, the method for providing the fluidic connection  2  in the second embodiment begins with the step of opening the second connecting arrangement  3 B′ by means of the mouth-shaped portion  5 A′ or destroying the opening region  4 B′ of the second connecting arrangement  3 B′ using the mouth-shaped portion  5 A′. 
     It is also envisaged in the second embodiment that the connecting arrangements  3 A′,  3 B′ are rotatable relative to one another or about the (common) central axis or axis of symmetry  9  in their connected state, particularly in the second connecting position. As a result, preferably the other of the connecting arrangements  3 A′,  3   b ′, i.e. the first connecting arrangement  3 A′, in particular, is opened, as explained in detail hereinafter with reference to  FIGS.  8  to  13   . 
     In one aspect it is preferable that the first opening region  4 A,  4 A′,  4 B,  4 B′ of the first connecting arrangement  4 A,  4 A′ can be opened by deformation by means of the second connecting arrangement  4 B,  4 B′. The opening regions  4 A,  4 A′,  4 B,  4 B′ can also be mutually opened by mutual deformation. Opening by deformation preferably does not require any shearing edges or severing elements, which is advantageous in terms of a simple manufacturing process with reduced use of materials. 
     The second connecting arrangement  3 B,  3 B′ is preferably configured to open the first connecting arrangement  3 A,  3 A′, while the second connecting arrangement  3 B,  3 B′ is preferably configured to open the opening region  4 A,  4 A′,  4 B,  4 B′ of the first connecting arrangement  4 A,  4 A′ by deformation of the first connecting arrangement  3 A,  3 A′. 
     Particularly preferably, in this aspect, the deformation is initiated by rotating the connecting arrangements  3 A,  3 A′ relative to one another, particularly about the common axis  9 , and/or opening the opening regions  4 A,  4 A′  4 B,  4 B′ of the first connecting arrangement  3 A,  3 A′. 
     The connecting arrangements  3 A,  3 A′,  3 B,  3 B′ preferably have non-round, particularly oval or at least substantially elliptical portions corresponding to one another which can be inserted in one another and/or cause deformation and/or opening when rotated relative to one another. 
     The deformation preferably brings about a tensioning of the opening region  4 A,  4 A′, at least substantially radially or transversely with respect to a central axis or axis of symmetry  9  or along the opening region of the opening region  4 A,  4 A′, as a result of which the opening region  4 A,  4 A′ is torn, broken or detached and/or the opening region  4 A,  4 A′ is opened. 
     At the same time, the second connecting arrangement  3 B,  3 B′ may have an, in particular film-shaped, brittle and/or unstable opening region  4 B,  4 B′, preferably with the first connecting arrangement  3 A,  3 A′ being configured for opening the second connecting arrangement  3 B,  3 B′. In particular, the first connecting arrangement  3 A,  3 A′ is configured to open the second connecting arrangement  3 B,  3 B′ by breaking through the opening region  4 B,  4 B′ of the second connecting arrangement  3 B,  3 B′. 
     The first connecting arrangement  3 A,  3 A′ preferably comprises a mouth-shaped portion  5 A,  5 A′ which adjoins the opening region  4 A,  4 A′ or surrounds the opening region  4 A,  4 A′, the mouth-shaped portion  5 A,  5 A′ being deformable so that the opening region  4 A,  4 B can be opened by the deformation. 
     The mouth-shaped portion  5 A,  5 A′ is preferably in the form of a web, a neck, a wall, a thin wall, or it is elastic and/or flexible, and/or the mouth-shaped portion  5 A,  5 A′ is more elastic, more flexible and/or more stable than the opening region  4 A,  4 A′, which is preferably opened on deformation of the mouth-shaped portion  5 A,  5 A′ the opening region  4 A,  4 A′, particularly by tearing, breaking or detaching. 
     The second connecting arrangement  3 B,  3 B′ is preferably configured for deforming the mouth-shaped portion of the first connecting arrangement  3 A,  3 A′, so that the deformation causes the opening region  4 A,  4 A′ of the first connecting arrangement  3 A,  3 A′ to open. 
     The mouth-shaped portion  5 A,  5 A′,  5 B,  5 B′ is preferably non-round, particularly oval, at least essentially elliptically and/or polygonal in cross section, while the second connecting arrangement  3 B,  3 B′ has a corresponding cross section, so that rotating the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ relative to one another causes deformation and/or opening of the first connecting arrangement  3 A,  3 A′ in their opening region  4 A,  4 A′. 
     Both connecting arrangements  3 A,  3 A′  3 B,  3 B′ preferably have mouth-shaped portions  5 A,  5 A′,  5 B,  5 B′ which can be arranged in oriented manner inside one another or can be pushed into one another, while rotation of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ or of the mouth-shaped portions  5 A,  5 A′,  5 B,  5 B′ relative to one another brings about deformation of the first and, preferably, the second mouth-shaped portion  5 A,  5 A′,  5 B,  5 B′. 
     The connecting arrangements  3 A,  3 A′,  3 B,  3 B′ can be connected to one another by a bayonet-type connection or they may comprise connectors or guides  18 A,  18 B, which are configured to form a bayonet-type connection. For this purpose, the mouth-shaped portions  5 A,  5 A′,  5 B,  5 B′ may initially be pushed or capable of being pushed (only) in the axial direction into one another and only afterwards may they be rotated or rotatable relative to one another, while preferably the fluidic connection  2  is not formed until they are rotated relative to one another. The guides  18 A,  18 B may thus be designed for a bayonet-type connection. For this purpose a (purely) axially extending guide may be adjacent to a (purely) radial guide. 
     Preferably, by rotating the connecting arrangements  3 A′,  3 B′ relative to one another while the mouth-shaped portion  5 A′ of the first connecting arrangement  3 A′ is arranged in the mouth-shaped portion  5 B′ of the second connecting arrangement  3 B′, the opening region  4 A′ of the first connecting arrangement  3 A′ is mechanically stressed, particularly tensioned by the deformation of the mouth-shaped portion  5 A′ of the first connecting arrangement  3 A′ to such an extent that it tears. 
     To improve the understanding of the opening mechanism for opening the first opening region  4 A′ of the first connecting arrangement  3 A′ from the second embodiment,  FIGS.  9  and  10    each show a plan view of a connecting arrangement  3 A′  3 B′. The second connecting arrangement  3 B′ shown in  FIG.  9    preferably has a mouth-shaped portion  5 B′ which resembles the mouth-shaped portion  5 A′ of the first connecting arrangement  3 A′ shown in  FIG.  10    in shape and/or outline, but is larger in its dimensions, diameters, longitudinal extent and/or transverse extent (at right angles to the central axis or axis of symmetry  9 ). 
     In particular, the second connecting arrangement  3 B′ comprises an inner circumferential edge  15 —indicated by dashed lines in the plan view in  FIG.  9   —which resembles an outer circumferential edge  16  of the mouth-shaped portion  5 A′, corresponds thereto and/or is configured so that the outer circumferential edge  16  can be accommodated by the inner circumferential edge  15 . Preferably, a maximum diameter of the inner circumferential edge  15  is greater than a maximum diameter of the outer circumferential edge  16  and/or a minimum diameter of the inner circumferential edge  15  is greater than a minimum diameter of the outer circumferential edge  16 , preferably by more than 2% or 3% and/or less than 40%, preferably less than 30%, more particularly less than 20%, 15% or 10%. This enables the mouth-shaped portions  5 A′,  5  B′ to be simply pushed one inside the other while at the same time reliably opening the opening region  4 A′ of the first connecting arrangement  3 A′. 
     The mouth-shaped portions  5 A′,  5 B′ can preferably be arranged inside one another or pushed into one another with play. As a result of the arrangement of the mouth-shaped portions  5 A′,  5 B′ a gap  17  or a spacing is formed (at least partially) between the inner circumferential edge  15  and the outer circumferential edge  16 . 
     In the embodiment shown, which relates to a particularly preferred variant, the mouth-shaped portions  5 A′,  5 B′ are each oval in cross section, particularly at least substantially elliptical. Theoretically, however, other shapes are possible, for example at least substantially square or other polygonal shapes. In theory it is preferable that the extent of the cross section in the main axial direction or the maximum extent in the secondary axial direction (centrally and transversally or perpendicularly to the main axial direction) exceeds or the minimum extent of the cross section by a factor of more than 1.2, preferably 1.3, particularly 1.5, and/or at least or at least substantially by a factor root of 2. This allows sufficiently strong deformation during rotation of the connecting arrangements relative to one another so that the opening of the opening region  4 A′ of the first connecting arrangement  3 A′ can take place reliably. 
     In  FIGS.  11  to  13    the connecting arrangements  3 A′,  3 B′ are shown in different rotational positions relative to one another, preferably in the second connecting position. 
     Preferably, the connecting arrangements  3 A′,  3 B′ can be turned or rotated through more than 45° and/or less than 200°, particularly less than 135° and/or at least substantially through 90°, in their (non-releasably) connected state or with the mouth-shaped portions  5 A′,  5 B′ inserted in one another, about the (common) central axis or axis of symmetry  9 . This ensures deformation of one or both mouth-shaped portions  5 A′,  5 B′ and/or opening of an opening region  4 A′,  4 B′, particularly of the opening region  4 A′ of the first connecting arrangement  3 A′. 
     In the embodiment shown in  FIG.  8    the mouth-shaped portions  5 A′,  5 B′ are similar, particularly with reference to a circumferential line radially of the central axis or axis of symmetry  9 , particularly so that after the first mouth-shaped portion  5 A′ has been inserted or pushed into the second mouth-shaped portion  5 B′ they rest loosely or with play on one another or at least partially abut directly on one another particularly at least at two points which are opposite one another in respect of the central axis or axis of symmetry  9  and/or at least 20%, preferably at least 50% of the respective circumferential line. 
     Because of the rotationally asymmetrical or non-round form of the mouth-shaped portions  5 A,  5 B, the rotation indicated by the rotation arrows  11  results in force which has a deforming effect on the first connecting arrangement  3 A′, particularly the mouth-shaped portion  5 A′ thereof. In the embodiment shown, the mouth-shaped portions  5 A′,  5 B′ are oval in cross section. This has proved particularly advantageous as it ensures that during rotation the mouth-shaped portions  5 A′,  5 B′ slide past one another without snagging and ensures at least substantially continuous deformation of the mouth-shaped portion  5 B′ of the second connecting arrangement  3 B′ during the rotation of the connecting arrangements  3 A′,  3 B′ relative to one another. However, other rotationally asymmetrical or non-round cross sections are also possible, such as rectangles, polygons, triangles or the like. 
       FIG.  12    shows, in a schematic section through the connecting system  1 , particularly in the second connecting position, the mouth-shaped portions  5 A′,  5 B′ in a position rotated through about 45° to one another. The respective mouth-shaped portions  5 A′,  5 B′ generate forces on one another so as to produce deformation of the mouth-shaped portion  5 B′ of the second connecting arrangement  3 B′ and, preferably at the same time, a, particularly corresponding, deformation of the mouth-shaped portion  5 A′ of the first connecting arrangement  3 A′. As indicated by the broken lines  12 , the deformation of the mouth-shaped portion  5 B′ leads to tensile and/or pressure stresses on the opening region  4 B′ and, preferably, as a result, leads to fracture or opening. 
       FIG.  13    shows a schematic section through the connecting system  1  as proposed, in which the first connecting arrangement  3 A′ has been rotated through at least substantially 90° relative to the second connecting arrangement  3 B′. Compared with the rotation through about 45° as shown in  FIG.  12   , the increasing rotation of the connecting arrangements  3 A′,  3 B′ relative to one another increases the tension or pressure and/or tensile stress on the opening region  4 B′ such that the opening region  4 B′ tears, breaks, becomes detached (at the edges) or opens in some other way. 
     The connecting system  1  according to the second embodiment preferably comprises a guide  18 A,  18 B (cf.  FIGS.  9  and  10   ) for connecting the connecting arrangements  3 A′,  3 B′ in a rotationally oriented position or for determining a rotational position during the connection thereof. In particular, a sliding guide or the like is provided by means of which the connecting arrangements  4 A′,  4 B′ or the mouth-shaped portions  5 A′,  5 B′ can only be fitted, placed or pushed into one another in certain rotational positions (with respect to the central axis or axis of symmetry  9 ), preferably such that the mouth-shaped portions  5 A′,  5 B′ are similarly oriented. 
     The mouth-shaped portion  5 A′,  5 B′ are similarly oriented particularly when main axes, longitudinal axes, transverse axes, ends, corners and/or the like coincide with one another at least substantially, particularly such that the first mouth portion  5 A′ can be pushed into the second mouth portion  5 B′ at least substantially without any deformation of the mouth portions  5 A′,  5 B′. 
     The guide  18 A,  18 B is preferably configured such that in the (second) connecting position or after the attachment of the connecting arrangements  3 A′,  3 B′ or after the mouth-shaped portions  5 A′,  5 B′ have been inserted or pushed into one another, it is possible to rotate these relative to one another, particularly about the central axis or axis of symmetry  9 . In particular, the guide  18 A,  18 B comprises a slide or a portion which extends axially or parallel to the central axis or axis of symmetry  9  and, thereafter, has a radially extending portion, resulting in the rotational movement described above. However, other solutions are also possible. 
     The aspects of the first and second embodiment can also be combined with one another. Thus, it is additionally possible for the second connecting arrangement  3 B,  3 B′ to comprise a severing element  7  which at least partially opens the opening region  4 A,  4 A′ of the first connecting arrangement  3 A,  3 A′ when the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ are placed inside one another. The mouth-shaped portion  5 A,  5 A′ can then be used to open, particularly to pierce, the opening region  4 B′ of the second connecting arrangement  3 A,  3 B′. Rotation of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ relative to one another about the central axis or axis of symmetry  9  then leads to deformation of one or both mouth-shaped portions  5 A,  5 A′,  5 B,  5 B′. This leads to tensioning of the opening region or regions  4 A,  4 A′,  4 B,  4 B′. In this way, further breaking and/or tearing of the opening region or regions  4 A,  4 A′,  4 B,  4 B′ can advantageously be achieved, as a result of which the fluidic connection  2  can be improved or the hydraulic cross section of the fluidic connection  2  can be enlarged. 
     The connecting arrangements  4 A,  4 A′,  4 B,  4 B′ are preferably configured for mutual opening and/or to complement and/or correspond to one another, so that the continuous fluidic connection  2  can be produced. 
     The connecting arrangements  3 A,  3 A′,  3 B,  3 B′ are preferably configured in order to produce a hydraulic cross section of more than 0.5 cm 2 , preferably more than 1 cm 2  when producing the fluidic connection  2 . This permits rapid and total mixing. 
     The connecting arrangements  3 A,  3 A′,  3 B,  3 B′ are preferably adapted to be axially inserted in one another, fitted into one another and/or formed without threads. This allows rapid and simple production of the fluidic connection  2 . 
     By the production of the fluidic connection  2 , the fluidic connection  2  preferably forms a passage between the containers B 1 , B 2 , B 3  which is sealed off from the environment. This prevents the ingress of foreign substances or germs. 
     The second connecting arrangement  3 B,  3 B′ is preferably configured to open the first connecting arrangement  3 A,  3 A′ by breaking through the first opening region  4 A,  4 A′ and/or the first connecting arrangement  3 A,  3 A′ is configured to open the second connecting arrangement  3 B,  3 B′ by breaking through the second opening region  4 B,  4 B′. By mutual destruction of the opening regions  4 A,  4 A′,  4 B,  4 B′ it is advantageously possible to produce an irreversible fluidic connection  2  of large enough diameter to allow rapid mixing. 
     The connecting system  1  is preferably self-sealing, as a result of the production of the fluidic connection  2 , in particular with at least one of the opening regions  4 A,  4 A′,  4 B,  4 B′ having a sealing action as a result of or after the production of the fluidic connection  2 , so that the continuous fluidic connection  2  forms a passage sealed off from the environment. Preferably, the production of the fluidic connection  2  forms a fluidic passage which is sealed off from the environment, particularly in fluid-tight, germproof and/or gas-tight manner. 
     For this purpose, one of the opening regions  4 A,  4 A′,  4 B,  4 B′ or a device forming the respective opening region, after being perforated or otherwise destroyed as a sealing element, particularly a sealing lip, may extend between the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ and in this way seal the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ with one another or relative to one another. 
     The connecting system  1  is preferably self-sealing in sterile or sterilizable manner as a result of the production of the fluidic connection  2 . In particular, the production of the fluidic connection  2  produces a seal which prevents the ingress of germs. 
     Preferably, in order to seal the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ relative to one another, a seal, particularly a sealing ring or sealing lip, is provided. 
     Particularly preferably, in order to seal the fluidic connection  2 , preferably from the environment, or to seal off the fluidic passage, at least one opening region  4 A,  4 A′,  4 B,  4 B′, preferably the second opening region  4 B,  4 B′, acts as a seal, as a result of or after the formation of the fluidic connection  2 . 
     In particular, it is envisaged that the at least one opening region  4 A,  4 A′,  4 B,  4 B′, preferably the second opening region  4 B,  4 B′, has a sealing effect or acts as a seal at least at the edges or forms the sealing ring or the sealing lip when the fluidic connection  2  has been made. Alternatively, or additionally, it may be envisaged that the at least one opening region  4 A,  4 A′,  4 B,  4 B′, preferably the second opening region  4 B,  4 B′, sealingly abuts on a connecting arrangement  3 A,  3 A′,  3 B,  3 B′, preferably the first or a corresponding connecting arrangement, particularly the mouth-shaped portion  5 A,  5 A′,  5 B,  5 B′ thereof, when it has been pierced with the mouth-shaped portion  5 A,  5 A′,  5 B,  5 B′ in order to produce the fluidic connection  2 . 
     At least one opening region  4 A,  4 A′,  4 B,  4 B′, preferably the at least one opening region  4 A,  4 A′,  4 B,  4 B′, is preferably constructed to inhibit cracking around the edges and/or to form a seal and/or it has a material construction or layered structure in the edge region, which differs by comparison with a central portion, so that the edge region is more stable and/or acts as a seal after the edge region has been opened. 
     The containers B 1 , B 2 , B 3  of the proposed container system B in the initial state have preferably been produced separately from one another and can be used separately and/or fluidically separated from one another. The connecting arrangements  3 A,  3 A′,  3 B,  3 B′ are preferably each fluidic ally sealed independently of one another in the initial state. After the fluidic connection  2  has been formed between the containers B 1 , B 2 , B 3 , these containers are preferably inseparably or non-releasably connected. 
       FIG.  14    shows another container B 3 , which may also be or form part of the container system B. The container system B preferably comprises the container B 3 . This has two different, corresponding and/or complementary connecting arrangements  4 A,  4 A′,  4 B,  4 B′. As a result, this container B 3  may serve as an adaptor between two other containers B 1 , B 2  and/or may be connected to different containers B 1 , B 2  and/or may allow more than two substances S 1 , S 2 , S 3  to be mixed. 
     The container B 3  comprises both the first connecting arrangement  3 A and the second connecting arrangement  3 B on different, preferably opposite, sides. The container B 3  thus preferably comprises the first connecting arrangement  3 A,  3 A′, on a first side, and the second of the connecting arrangements  3 B,  3 B′ on a second side remote from the first side. This container is preferably free from removal openings E 1 , E 2 . 
     Moreover, the further container B 3  is configured to produce a fluidic connection  2  on both sides by means of the proposed connecting system  1 . The further container B 3  may comprise or encompass an additional, further substance S 3  different from the previous substances S 1 , S 2 , particularly a dry or freeze-dried substance (lyophilisate). 
     A plurality of containers B 3  may be joined to one another and/to the first and/or second container B 1 , B 2 . In this way, more than three substances S 1 , S 2 , S 3  may be mixed and/or a combination of more than 3 containers B 1 , B 2 , B 3  may be formed and/or more than three containers B 1 , B 2 , B 3  may be fluidically connected to one another. 
     As already explained in conjunction with  FIG.  1   , the proposed connecting system  1  is preferably used for fluidically connecting bottles or bottle-shaped containers B 1 , B 2 , particularly for the pharmaceutical sector. It is particularly preferable that the opening regions  4 A,  4 B,  4 A′  4 B′ should be adapted to be covered in sterile manner for transportation. 
       FIG.  15    shows a schematic perspective view of a first connecting arrangement  3 A with a severing element  7  arranged on the opening region  4 A. In the embodiment shown in  FIG.  15    the severing element  7  has four or (in dashed lines) three legs, but may also have more legs  19 . The legs  19  are preferably wedge-shaped at least partially or in areas or have cutting edges remote from the opening region  4 A. The severing element  7  preferably has a point  20  which is directed away from the opening region  4 A. The point  20  preferably adjoins the legs  19  or vice versa. By means of the point  20  and/or the legs  19 , shear forces can be increased and the destruction or perforation of the opening region  3 B can be facilitated. However, other alternative embodiments for the severing element  7  are theoretically possible. 
     In the embodiment shown, the severing element  7  comprises preferably foot-shaped connecting portions  21  with the opening region  4 B. These may be configured to derive or distribute a force exerted by the severing element  7 , particularly the point  20  or the legs  19 , onto the opening region  4 A. Alternatively or additionally, the connecting portions  21  may be provided and arranged so that when the connecting arrangements  3 A,  3 B are pushed inside one another the mouth-shaped portion  5 B comes to bear on the connecting portions  21  or in the vicinity thereof, as a result of which the shear forces acting on the opening region  4 B can be generated or increased. This assists with the opening of the opening region  4 A. 
     The severing element  7  is preferably arranged and/or configured for piercing, severing, cutting or destroying the opening region  4 A,  4 A′ of the first connecting arrangement  3 A,  3 A′. 
     The severing element  7  is preferably arranged and/or fastened on the opening region  4 B,  4 B′ of the second connecting arrangement  3 B,  3 B′, particularly directly. Alternatively, or additionally, the severing element  7  is configured to concentrate a force acting on the opening region  4 A,  4 A′ and/or to distribute a force or counter-force acting on the opening region  4 B,  4 B′ such that the opening region  3 B of the second connecting arrangement  3 B,  3 B′ remains intact when the opening region  4 A,  4 A′ is opened by destruction thereof by means of the severing element  7 . 
     In another aspect it is envisaged that the severing element  7  comprises one or more connecting portions  21  to which or with which the severing element  7  is connected, preferably by material engagement, with the opening region  4 A,  4 A′,  4 B,  4 B′. 
     The connecting portions  21  preferably form frangible points for the opening region  4 B,  4 B′ of the second connecting arrangement  3 B,  3 B′. Preferably, the connecting portions  21  are arranged to correspond to the first connecting arrangement  3 A,  3 A′, particularly the mouth-shaped portion  5 A,  5 A′ thereof. Moreover, the connecting portions  21  are preferably configured so that forces acting on the opening region  4 B,  4 B′ of the second connecting arrangement  3 B,  3 B′ are concentrated by the first connecting arrangement  3 A,  3 A′. This makes it easier to destroy and/or open the opening region  4 B,  4 B′ of the second connecting arrangement  3 B,  3 B′ by means of the first connecting arrangement  3 A,  3 A′, particularly the mouth-shaped portion  5 A,  5 A′ thereof. 
       FIG.  16    shows the proposed container system in a transporting position or orientation. The containers B 1 , B 2 , B 3  are preferably releasably connectable to one another for transporting as a result of a portion or bottle neck F 1 , F 2  of a container B 1 , B 2 , B 3  that forms the removal opening being adapted to be held by the holding device of the cap-shaped cover device  6 . 
     The first container B 1  is preferably provided with the cover device  6  or the first connecting arrangement  3 A,  3 A′ is covered by the cover device  6 . The second container B 2  is received and/or held by the cover device  6 , preferably in or by means of the region of its removal opening E 2  or its bottle neck F 2 . In this way or by some other means, the containers B 1 , B 2  of the container system may form a kit or a combination which associates the containers B 1 , B 2  with one another. This advantageously makes it possible to avoid unintended combinations of containers B 1 , B 2  or substances S 1 , S 2 . 
     The cover device  6  can preferably be held on the first container B 1  and is configured to hold both the region of the removal opening E 1 , E 2  or the bottle neck F 1 , F 2  of the first container B 1  and also of the second container B 2 . In this way the cover device  6  has a triple function, namely for providing a (sterile) cover, for forming a transport combination and as a support foot. The latter will be discussed further hereinafter. 
       FIG.  17    shows the first container B 1  in longitudinal section, the first connecting arrangement  3 A being covered, preferably in sterile manner, by the cover device  6 . The cover device  6  may be removably held on the container B 1  by means of or using one of the securing devices  10 A,  10 B or by some other means on the first container B 1 . 
     One or both opening regions  4 A,  4 A′,  4 B,  4 B′ are preferably covered in sterile or sterilizable manner One of the opening regions  4 A,  4 A′,  4 B,  4 B′ is preferably separated from the environment in sterile manner by the cap-shaped cover device  6 . An (another) opening region  4 A,  4 A′,  4 B,  4 B′ is preferably separated from the environment in sterile or sterilizable manner by a removable, detachable, tear-off and/or film-shaped closure  14 . 
     A double closure may be formed by the respective opening region  4 A,  4 A′,  4 B,  4 B′ and the respective sterile or sterilizable cover. In this way a sterile or sterilizable or sterile sealed region or space or cavity can be formed between the sterile or sterilizable cover and the respective connecting arrangement  3 A,  3 A,  3 B,  3 B′. 
     The sterile or sterilizable cover is preferably removable. This makes it possible to produce a (sufficiently) sterile fluidic connection  2  through the connecting system  1 , by removing the covers and using the opening regions  4 A,  4 A′,  4 B,  4 B′ arranged in the sterile area to form the fluidic connection  2 . 
     In the embodiment shown, the cap-shaped cover device  6  forms a sterile cover for the first opening regions  4 A,  4 A′ and/or the closure  14  forms a sterile cover for the second opening region  4 B,  4 B′ by means of a sealed or welded-on or otherwise tightly applied film. Theoretically, however, the sterile covering may also be provided by other means, for example by replacing the film with a cap or a (screw) closure, optionally with a seal or the like, and/or by constructing the cover device  6  without holding means or with a different holding device. 
     Sterile in the sense of the present invention denotes, in particular, at least substantially germ-free or aseptic. A sterile or sterilizable cover is preferably a device designed to prevent the penetration of germs, particularly by forming a germproof barrier. 
     From the construction point of view, a sterile or sterilizable cover is preferably tightly applied or connected to the respective connecting arrangement  3 A,  3 A′,  3 B,  3 B′ so as to form a germproof barrier. 
     A cover is sterilizable particularly when the cover uses materials, or the sterile or sterilizable cover comprises or is formed from materials, which are suitable for the use of at least one method of sterilization known in the prior art for destroying germs. For example, such materials may be sterilized by one of the known sterilization methods without being damaged thereby or losing their function as a barrier against the ingress of germs. The known sterilization methods include irradiation, particularly with gamma rays or an electron beam, gassing, treatment with hot air or autoclaving. Preferably, the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ are also sterile or sterilizable. 
     The opening regions  4 A,  4 A′,  4 B,  4 B′ are preferably produced independently of one another or separately from one another in an initial state and/or are covered in sterile or sterilizable manner separately from one another. This enables the containers B 1 , B 2 , B 3  to be used separately. 
     Between the opening region  4 A,  4 A′,  4 B,  4 B′ and the sterile or sterilizable cover or means for sterile covering, particularly the cover device  6  and/or the closure  14 , a space is preferably formed which is sterilized, sterilizable and/or sealed in sterile manner in an initial state or sealed off to be airtight and/or germproof. 
     According to another aspect of the present invention which can also be implemented independently, a substance, particularly an active substance, vaccine and/or adjuvant is arranged, attached and/or immobilized in the space. In particular, the substance is arranged in a lattice in the space and/or held by the severing element  7 . 
     In a preferred aspect the severing element  7  or another part of one of the connecting arrangements can be dissolved, solubilized and/or suspended within the space. In this way, after the fluidic connection  2  has been made, the substance from the space may form part of the mixture of substances S 1 , S 2 , S 3 . 
     The substance arranged in the space may be dissolved and/or solubilized and/or suspended on the connecting arrangement  3 A,  3 B,  3 A′,  3 B′ or on the opening region  4 A,  4 A′,  4 B,  4 B′ by means of one of the substances S 1 , S 2 , S 3 . 
     In a preferred aspect, a lyophilisate is dried onto or otherwise applied to the opening region. The lyophilisate as well as one or more of substances S 1 , S 2 , S 3  may contain vaccine, active substance, and/or adjuvant for preparing a vaccine or combined vaccine. In this way, after the production of the fluidic connection  2 , the substance arranged in the space may form a component of a substance mixture, particularly a combined vaccine. 
     The means for sterile covering, particularly the cover device  6  and/or the closure  14 , are preferably removable or detachable, particularly manually or without the use of tools, so that the opening regions  4 A,  4 A′,  4 B,  4 B′ are accessible for producing the fluidic connection  2 . 
     One of the containers B 1 , B 2 , B 3  preferably comprises, on a side remote from the removal opening E 1 , E 2 , the removable cap-shaped cover device  6  which in a starting position closes off the connecting arrangement  3 A,  3 A′,  3 B,  3 B′, preferably in sterile manner. 
     The cap-shaped cover device  6  preferably comprises a holding device for a removal opening E 1 , E 2  or a bottle neck F 1 , F 2 . A holding device, particularly the receptacle  13 , is preferably configured for holding a portion of a container B 1 , B 2 , B 3 , particularly the bottle neck F 1 , F 2 , forming the removal opening E 1 , E 2 , E 3 . 
     The cover device  6  preferably comprises a holding portion which is shaped like a shoulder and/or to correspond to or complement a shoulder region of the container B 1 , B 2  adjacent to the removal opening E 1 , E 2 . 
     In the embodiment shown the cover device  6  preferably comprises the receptacle  13  which is configured to receive and/or retain, preferably by interlocking or latching engagement, the bottle neck F 1 , F 2  of the container or containers B 1 , B 2 . 
     The cover device  6  is preferably embodied as a holder or stand for the container or containers B 1 , B 2 . For this purpose the removal opening E 1 , E 2  or the bottle neck F 1 , F 2  can preferably be inserted in the cover device  6 . In particular, the receptacle  13  is configured for clamping and/or latching and/or releasably holding the container or containers B 1 , B 2 , preferably in the region of the removal opening E 1 , E 2  and/or the bottle neck F 1 , F 2 . This advantageously allows reliable operation as a foot or stand and/or for holding or forming the kit or combination of containers B 1 , B 2 , particularly bottles, of the container system B. 
     The cover device  6  preferably serves as a base or standing surface for one of the containers B 1 , B 2 , particularly the first container B 1 , if its opening region  4 A is covered by the cover device  6 . It may be provided that the receptacle  13  is arranged at the bottom in a starting position and/or is accessible from outside. This has the additional advantage that the containers B 1 , B 2  can be stacked by placing the first container B 1  comprising the cover device  6  with the receptacle  13  onto the second container B 2  in such a way that its removal opening E 2  or bottle neck F 2  is pushed into the receptacle  13  and preferably held, particularly by latching and/or clamping. In this way a kit can be produced in which the containers B 1 , B 2  are releasably joined together, thus helping to prevent incorrect packing and erroneous mixing of substances using the connecting system  1 . 
     For using the proposed connecting system  1  it may be envisaged that first of all the cover device  6  is separated or removed from the first container B 1  (cf.  FIG.  18   ). 
     As shown in  FIG.  19   , by way of example, the first container B 1  (or alternatively the second container B 2 ) is then preferably inserted with the removal opening E 1 , E 2  or the bottle neck F 1 , F 2  or a part thereof in the receptacle  13  of the cover device  6 . For this purpose the cover device  6  may be used with the opening of the receptacle  13  directed upwards in the position of use, the removal opening E 1 , E 2  or the bottle neck F 1 , F 2  being pushed into the receptacle  13  at least partially from above in the position of use. Theoretically, however, it is also possible to insert the container B 1 , B 2  into the receptacle  13  in other positions. Preferably, the cover device  6  is then used as a holder or foot or at the bottom in the position of use. Thus the first connecting arrangement  3 A or its opening region  4 A is accessible from above in the position of use. 
     The cover device  6  can be used as a standing foot for the container B 1 , B 2 , B 3  if the container B 1 , B 2 , B 3  is held by the holding device or receptacle  13  with the portion forming the removal opening E 1 , E 2  or the bottle neck F 1 , F 2 . 
     The cover device  6  thus preferably forms a holder or foot for the container B 1 , B 2  which is held by the cover device  6 . The dual function of the cover device advantageously saves space and material and additionally using the cover device  6  as a holder or foot advantageously prevents contamination of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′. 
     The cover device  6  is preferably of cap-shaped formation and in a starting or transporting position it forms a tight seal with the connecting arrangement  3 A,  3 A′,  3 B,  3 B′, so as to produce a sterile or sterilizable closure. 
     The cover device  6  preferably comprises the receptacle  13  and a holding portion for holding onto the connecting arrangement  3 A,  3 A′,  3   b ,  3 B′ on different sides, particularly opposite sides. The holding portion may have a region which is releasably fixed or fixable to the connecting arrangement  3 A,  3 A′,  3   b ,  3 B′ by a clamping and/or latching action. For this purpose the cover device  6  in the holding portion and the connecting arrangement  3 A,  3 A′,  3   b ,  3 B′ may be of complementary or corresponding construction. 
     The cover device  6  is preferably made of plastics or contains plastics. The cover device  6  is preferably a thermoformed part or an injection molded part and/or a shaped part produced from a sheet material. The cover device  6  preferably has a wall thickness of more than 1 mm and/or less than 2 mm. However, other solutions are also possible here. 
     In the embodiment shown, the cover device  6  is essentially in the shape of a W or U in longitudinal section, with an indentation in the curve of the U which forms the receptacle  13 . In principle, however, the cover device  6  may also be formed differently for the dual function of a sterile closure on the one hand and a holding device on the other. 
       FIG.  20    shows the second container B 2  in which the opening region  4 B is closed off, particularly in sterile manner, by the closure  14 , particularly a removable cover, film, sealing film or the like. Preferably the closure  14  is removable, particularly by pulling off, in order to use the proposed connecting system  1 . The closure  14  may have a tab for this purpose. 
     At least one of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′, specifically the second connecting arrangement  3 B,  3 B′ in the embodiment shown, preferably has a receptacle for another one of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ which may preferably be formed by a collar-shaped portion  22  or alternatively or additionally by some other means. The collar-shaped portion  22  may assist with fitting the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ into one another, guide the required movement and/or protect the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ at the sides. It preferably comprises the securing devices  10 A,  10 B or parts thereof. 
     Preferably, one of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′, particularly the second connecting arrangement  3 B,  3 B′, is surrounded by the collar-shaped portion  22  in the (first and/or second) connecting position. 
     The collar-shaped portion  22  preferably serves to receive the (respectively) other connecting arrangement  3 A,  3 A′,  3 B,  3 B′ or to form a receptacle and/or guide, preferably a linear guide for this purpose, particularly in the direction of the central axis or axis of symmetry  9 . 
     In the embodiment shown the collar-shaped portion  22  is provided on or around the second connecting arrangement  4 B,  4 B′ or on the second container B 2 . Alternatively or additionally, however, the collar-shaped portion  23  may also be provided around the first connecting arrangement  4 A,  4 A′ or on the first container B 2 . 
     The collar-shaped portion  22  is preferably fixedly, rigidly and/or non-rotationally connected to a or the associated connecting arrangement  3 A,  3 A′,  3 B,  3 B′, preferably by interlocking engagement, particularly by latching, and/or by frictional engagement, particularly by clamping, and/or by material connection, particularly by adhesive bonding or injection molding, but alternatively also by being formed in one piece with one of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ or containers B 1 , B 2 . 
     The collar-shaped portion  22  preferably projects beyond the mouth-shaped portion  5 A,  5 B,  5 A′,  5 B′ and/or extends at least partially parallel thereto or in the same direction and preferably thereby forms the receptacle or linear guide for the other one of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′. 
     The collar-shaped portion  22  or the receptacle that may be formed by it preferably at least partially comprises the guide  18 A,  18 B, particularly the slide, a guide pin or the like. 
     An open edge of the collar-shaped portion  22  preferably forms a stop for those of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ which it does not surround in the separated state of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ and/or for the container B 1  connected thereto. Preferably in the second connecting position the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ abut on one another in the region of the stop. 
     The collar-shaped portion  22  is preferably closed off, particularly in sterile manner, at one end or on an open side by the closure  14 , particularly a film applied as a seal. 
       FIG.  21    shows by way of example how the containers B 1 , B 2  can be fluidically connected to one another by the proposed connecting system  1 . For this purpose the closure  14  is preferably removed from the second container B 2  and the second container B 2  is then placed with the second connecting arrangement  3 B,  3 B′ onto the first connecting arrangement  3 A,  3 A′ from above. In the embodiment shown the first connecting arrangement  3 A,  3 A′ extends into the receptacle formed by the collar-shaped portion  22 . 
     Then the opening regions  4 A,  4 A′,  4 B,  4 B′ are opened. By combining the connecting arrangements  3 A,  3 B, which form, in particular, base regions of the bottles or bottle-shaped containers B 1 , B 2 , the fluidic connection  2  can be produced, as already explained in relation to  FIGS.  2  to  8   .  FIG.  21    shows the first embodiment but the same also applies to the second embodiment and the combination of embodiments. 
     According to another aspect of the present invention which can also be implemented independently, the connecting system  1  or the connecting arrangements  3 A,  3 B,  3 A′,  3 B′ are specific to a particular size of container. 
     In particular, a proposed container system B comprises containers B 1 , B 2 , B 3  of different sizes, volumes and/or with specific quantities of substance S 1 , S 2 , S 3  for producing a desired mixing ratio. For this it is preferable for the connecting arrangements  3 A,  3 B,  3 A′,  3 B′ to be selectively configured (mechanically) such that containers B 1 , B 2 , B 3  with compatible contents can be connected and containers B 1 , B 2 , B 3  with incompatible contents, or containers B 1 , B 2 , B 3  which would lead to an undesirable or unsuitable mixing ratio if a fluidic connection  2  were produced, have connecting arrangements  3 A,  3 B,  3 A′,  3 B′ which are mechanically incompatible with one another. 
     Particularly preferably, the connecting arrangements  3 A,  3 B,  3 A′,  3 B′ may be constructed selectively with respect to one another, particularly according to the lock and key principle. This can be achieved using guides  18 A,  18 B, guiding slides, diameters or the like which are compatible or incompatible with one another, respectively. 
     The aspects of the present invention described in connection with  FIGS.  16  to  21    may be advantageous on their own and in various combinations, preferably wholly or partially or in certain details in the sequence of the explanations. In particular, the cover device  6  is preferably removed and used as a holder or foot before the second connecting arrangement  3 B is opened or unsealed, particularly by removal of the closure  14 . 
     Moreover,  FIGS.  16  to  21    show the connecting arrangements  3 A,  3 B of the first embodiment. Instead of these, however, it is also possible to use the connecting arrangements  3 A′,  3 B′ of the second embodiment or a combination of the first connecting arrangements  3 A,  3 A′ and the second connecting arrangements  3 B,  3 B′. The aspects explained then apply accordingly. 
     The fluidic connection  2  may thus alternatively or additionally be produced by deformation. In this case the severing element  7  is optional and the collar-shaped portions  22  are preferably non-round in cross section, so that when the connecting arrangements  3 A,  3 B,  3 A′,  3 B′ are rotated relative to one another the fluidic connection  2  is produced by shaping or deformation. In the interests of clarity, the corresponding procedure will not be repeated here. 
     Further aspects of the present invention which may be implemented separately and combined with one another and/or may be implemented with aspects and features of the present invention as explained hereinbefore and which are advantageous will be described in more detail hereinafter. 
     An aspect of the present invention which can be implemented independently, or in conjunction with one or more of the preceding aspects, relates to a connecting system  1  for producing a fluidic connection  2 , preferably between containers B 1 , B 2 , B 3 , wherein the connecting system  1  comprises at least two connecting arrangements  3 A,  3 A′,  3 B,  3 B′ configured to form the fluidic connection  2 , namely a first connecting arrangement  3 A,  3 A′ and a second connecting arrangement  3 B,  3 B′, which, in an initial state, are each fluidically sealed and are sealed independently of one another, the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ being capable of insertion in one another and/or being adapted to be inserted in one another by a preferably at least substantially linear and/or axial movement along a common axis, by means of which at least one of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ can be opened. 
     In particular, the fluidic connection  2  is formed by an insertion process. This is advantageously carried out, for example, by producing the fluidic connection  2  particularly quickly and reliably, in particular without the need for repeated rotation of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ by means of a helical line with a number of turns or by means of a thread. 
     The insertion of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ into one another also allows the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ to be brought together in a manner oriented with one another in relation to the position of rotation about the (common) axis of symmetry or central axis  9 , which is particularly advantageous if the mouth portions  5 A,  5 A′,  5 B,  5 B′ of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ are non-round in cross section or the opening of at least one of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ is produced by deformation and the resultant tensioning of an opening region  4 A,  4 A′,  4 B,  4 B′. 
     An aspect of the present invention which can also be implemented independently or in conjunction with one or more of the preceding aspects relates to a connecting system  1  for producing a fluidic connection  2 , preferably between containers B 1 , B 2 , B 3 , wherein the connecting system  1  comprises at least two connecting arrangements  3 A,  3 A′,  3 B,  3 B′ configured to produce the fluidic connection  2 , namely a first connecting arrangement  3 A,  3 A′ and a second connecting arrangement  3 B,  3 B′, which are fluidically sealed off in a starting state, the first connecting arrangement  3 A,  3 A′ having an in particular film-shaped, brittle and/or unstable opening region  4 A,  4 A′,  4 B,  4 B′, being deformable outside the opening region  4 A,  4 A′,  4 B,  4 B′ and being configured so that the deformation causes opening of the first connecting arrangement  3 A,  3 A′,  3 B,  3 B′ in the opening regions  4 A,  4 A′,  4 B,  4 B′. 
     An aspect of the present invention which can also be implemented independently, or in conjunction with one or more of the preceding aspects, relates to one or more containers B 1 , B 2 , B 3  or vessels which comprise connecting arrangements  3 A,  3 A′,  3 B,  3 B′ in each case. 
     An aspect of the present invention which can also be implemented independently or in conjunction with one or more of the preceding aspects relates to a connecting system  1  for producing a fluidic connection  2 , preferably between containers B 1 , B 2 , B 3 , the connecting system  1  having at least two connecting arrangements  3 A,  3 A′,  3 B,  3 B′ configured to produce the fluidic connection  2 , the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ each comprising an opening region  4 A,  4 A′,  4 B,  4 B′ which is fluidically closed in a starting state, particularly in the manner of a film, or is brittle, fragile and/or unstable, the opening regions  4 A,  4 A′,  4 B,  4 B′ each being covered in sterile or sterilizable manner. 
     In particular, the opening or formation of the fluidic connection  2  is thus achieved by the fact that the opening region  4 A,  4 A′ of the first connecting arrangement  3 A,  3 A′ is or forms a frangible point, so that deformation of the first connecting arrangement  3 A,  3 A′, particularly by tensioning, leads to tearing or breaking of the opening region  4 A,  4 A′. This has the particular advantage that no point or other severing element is required for this opening process. Severing elements  7  usually have to be sharp-edged and stabilized to allow the opening up of an opening region  4 A,  4 A′,  4 B,  4 B′. Consequently, by avoiding such a severing element, the manufacturing process can use gentler materials and/or be simpler. As already explained hereinbefore, however, a combination of the above aspects using a severing element  7  is also possible, while the present aspect is advantageous for enlarging or expanding an opening or the fluidic connection  2 . 
     The sterile or sterilizable covers of the opening regions  4 A,  4 A′,  4 B,  4 B′ advantageously make it possible to produce the fluidic connection  2  while excluding germs or other foreign substances, particularly in the pharmaceutical/medical sector. Alternatively or additionally, the sterile or sterilizable covering of the opening regions  4 A,  4 A′,  4 B,  4 B′ offers the possibility of using containers B 1 , B 2 , B 3  with the connecting arrangement  3 A,  3 A′,  3 B,  3 B′ separately from one another in this environment and optionally in combination with one another. 
     One aspect of the present invention which can also be implemented independently or in conjunction with one or more of the preceding aspects relates to a container system B with at least two containers B 1 , B 2 , B 3 , preferably bottles, and the connecting system  1 , wherein the containers B 1 , B 2 , B 3  for providing a fluidic connection  2  between the containers B 1 , B 2 , B 3  in each case comprise at least one connecting arrangement  3 A,  3 A′,  3 B,  3 B′ of the connecting system  1 . 
     In this connection, the use of the proposed connecting system  1  for connecting containers B 1 , B 2 , B 3  has proved advantageous particularly because it is possible to produce a non-releasable and/or irreversible fluidic connection  2  between the containers B 1 , B 2 , B 3 , thus ensuring complete mixing of the contents of the containers B 1 , B 2 , B 3 . 
     Another aspect of the present invention which can also be implemented independently or in conjunction with one or more of the preceding aspects relates to a container system B with at least two containers B 1 , B 2 , B 3 , preferably bottles, each of which comprises a removal opening E 1 , E 2 , preferably each closed off by a septum, while preferably the containers B 1 , B 2 , B 3  comprise, on a side remote from the respective removal opening E 1 , E 2 , particularly on the base of the respective bottle, a connecting arrangement  3 A,  3 A′,  3 B,  3 B′ for providing a fluidic connection  2  between the containers B 1 , B 2 , B 3  and/or are configured for providing a fluidic connection  2  between the containers B 1 , B 2 , B 3 . 
     The use of two containers B 1 , B 2 , B 3 , each of which comprises a removal opening E 1 , E 2  and a connecting arrangement  3 A,  3 A′,  3 B,  3 B′, is particularly advantageous because the containers B 1 , B 2 , B 3  can also be used separately from one another, but at the same time, in the event of joint use by means of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′, a fluidic connection with a relatively large cross-section is made possible for the rapid or accelerated mixing of the contents of the containers B 1 , B 2 , B 3 . 
     Another aspect of the present invention which can also be implemented independently or in conjunction with one or more of the preceding aspects relates to a method for providing a fluidic connection  2  between connecting arrangements  3 A,  3 A′,  3 B,  3 B′ and/or containers B 1 , B 2 , B 3  by means of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′, wherein in an initial state the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ are in each case fluidically sealed, wherein a first connecting arrangement  3 A,  3 A′ is opened by another, second connecting arrangement  3 B,  3 B′ and the second connecting arrangement  3 B,  3 B′ is opened by the [omission], thus producing a continuous fluidic connection  2  between the connecting arrangements  3 A,  3 A′,  3 B,  3 B′. 
     This results in corresponding advantages, i.e. in particular a rapid and reliable formation of the fluidic connection  2  or mixing of the substances S 1 , S 2 , S 3 . 
     Another aspect of the present invention which can also be implemented independently or in conjunction with one or more of the preceding aspects relates to a use of a container system B, wherein a first container B 1  holds a first substance S 1 , particularly a first vaccine against a first disease, while a second container B 2  holds a second substance S 2 , particularly a second vaccine against a second disease different from the first, for the preparation of a mixture of substances, particularly for the preparation of a combined vaccine for simultaneous immunization against different diseases, wherein the containers B 1 , B 2 , B 3  are fluidically connected to one another by means of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′, so that the substances are mixed together, particularly to form the combined vaccine. 
     The use of the proposed connecting system  1  or container system B for the preparation of combined vaccine is advantageous for example because the vaccines may be used individually or in combination, as desired. The proposed connecting system  1  or container system B offers the flexibility of deciding on the spot whether the substances S 1 , S 2 , S 3  or vaccines are to be administered individually or in combination. This advantageously avoids subjecting animals to stress by an unnecessarily large number of separate injections or unnecessarily always having to vaccinate them with a combined vaccine, even when there is no need for one of the vaccines to be given, because of an existing immunity. In this way, the present invention can save materials and costs. 
     Another aspect of the present invention which can also be implemented independently or in conjunction with one or more of the preceding aspects relates to a method for providing a fluidic connection  2  between connecting arrangements  3 A,  3 A′,  3 B,  3 B′ and/or containers B 1 , B 2 , B 3  by means of connecting arrangements  3 A,  3 A′,  3 B,  3 B′ of the connecting system  1 , wherein preferably the means for sterile covering, particularly the cover device and/or the closure  14 , is removed from the opening regions  4 A,  4 A′,  4 B,  4 B′ in each case and the still closed opening regions  4 A,  4 A′,  4 B,  4 B′ thus exposed are opened up to form the fluidic connection  2 . 
     Another aspect of the present invention which can also be implemented independently or in conjunction with one or more of the preceding aspects relates to a method for providing a fluidic connection  2  between connecting arrangements  3 A,  3 A′,  3 B,  3 B′ and/or containers B 1 , B 2 , B 3  by means of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′, wherein in an initial state the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ are in each case fluidically sealed, while a first connecting arrangement  3 A,  3 A′ is opened by another second connecting arrangement  3 B,  3 B′ and the second connecting arrangement  3 B,  3 B′ is opened by the first connecting arrangement  3 A,  3 A′, thus producing a continuous fluidic connection  2  between the connecting arrangements  3 A,  3 A′,  3 B,  3 B′. 
     In another aspect which may thus be implemented independently, the present invention relates to a kit with two proposed containers B 1 , B 2 , B 3  or with containers B 1 , B 2 , B 3 , which can be fluidically connected to one another by means of the connecting system  1 , so that a mixture of the substances S 1 , S 2 , S 3  contained in the containers B 1 , B 2 , B 3  can be formed. This prevents other, incompatible substances S 1 , S 2 , S 3  from being mixed. 
     A kit in the sense of the present invention is particularly a combination and/or system comprising the first container B 1  and the second container B 2 , which form the components of the kit. The kit may also comprise the third container B 3  and/or further containers or components. 
     The components of the kit are preferably marketed as a set, particularly in a joint pack or the like. However, it is also possible for the components to form a loose combination to be used together. A common or connecting component may be provided, for example a common set of instructions for use, handling recommendations, information in the text on one or more of the components of the kit or the like. 
     Preferably, the containers B 1 , B 2 , B 3  form a kit by being held together, particularly preferably by means of the cover device  6  or the receptacle  13 . 
     The containers B 1 , B 2 , B 3  are preferably designed for the preparation of a combined vaccine for simultaneous immunization against different diseases, preferably by making the containers B 1 , B 2 , B 3  capable of fluidic connection to one another by means of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′, so that substances S 1 , S 2 , S 3  located in the containers B 1 , B 2 , B 3  are mixed together to form the combined vaccine, while in particular the substances S 1 , S 2 , S 3  can be removed through the removal opening E 1 , E 2  separately from one another and then used, particularly before or without forming the fluidic connection  2 . 
     Preferably, at least one of the containers B 1 , B 2 , B 3  comprises a removal opening E 1 , E 2 , preferably closed off with a septum, while the container B 1 , B 2 , B 3  is preferably configured, on a side remote from the removal opening E 1 , E 2 , particularly on the bottom of the bottle, for providing a fluidic connection  2  between the containers B 1 , B 2 , B 3  and/or comprises the connecting arrangement  3 A,  3 A′,  3 B,  3 B′. 
     The containers B 1 , B 2 , B 3  are preferably fluidically connected to one another by means of the connecting arrangements  3 A,  3 A′,  3 B,  3 B′, so that the substances are mixed together, preferably forming a combined vaccine. 
     In another aspect which may thus be implemented independently, the present invention relates to the use of a connecting system  1 , kit or container system B as proposed, for the preparation or provision of medicaments for live animals, preferably mammals, and/or for medical uses. 
     In another aspect which may thus be implemented independently, the present invention relates to the use of a connecting system  1 , kit or container system B as proposed, for the preparation and/or provision of a vaccine, particularly for immunizing against the disease(s) Porcine Circovirus Disease “PCVD” and/or Enzootic Pneumonia “EP” or infections with Porcine Circovirus and/or infection with bacteria of the  Mycoplasma  strain, particularly  Mycoplasma hyopneumoniae , preferably for immunizing against the diseases Porcine Circovirus Disease “PCVD” and Enzootic Pneumonia “EP” or against infections with Porcine Circovirus and/or infection with bacteria of the  Mycoplasma  strain, particularly  Mycoplasma hyopneumoniae.    
     For this purpose a first proposed container B 1  contains as the first substance S 1  a first reactant and a second proposed container B 2  contains as the second substance S 2  a second reactant. The reactants may be vaccines against different diseases or the educts may contain vaccines against different diseases. 
     It is particularly preferable for the first reactant to contain only a first one of the components  Mycoplasma  vaccine or  Mycoplasma  antigen and Circovirus vaccine or Circovirus antigen (and optionally other substances). The first reactant may thus contain either  Mycoplasma  vaccine, or one or more  Mycoplasma  antigens or alternatively Circovirus vaccine or one or more Circovirus antigens. The first reactant is preferably stored separately from the second reactant, particularly if the reactants are not stable in the long term together. The second reactant preferably contains only the other one of the components  Mycoplasma  vaccine or one or more  Mycoplasma  antigens and Circovirus vaccine or one or more Circovirus antigens (and optionally other substances). If the first reactant thus contains  Mycoplasma  vaccine or one or more  Mycoplasma  antigens, the second reactant contains Circovirus vaccine or one or more Circovirus antigens, or vice versa. 
     The  Mycoplasma  vaccine may contain attenuated and/or inactivated bacteria, fragments of bacteria or recombinantly prepared parts of  Mycoplasma hyopneumoniae , but at least one or more  Mycoplasma hyopneumoniae  antigens. Preferably, the  Mycoplasma hyopneumoniae  antigen originates from the  Mycoplasma hyopneumoniae  J-strain or the inactivated  Mycoplasma hyopneumoniae  bacteria are those of the J-strain. Moreover, the  Mycoplasma  vaccine may be one of the following vaccines or the  Mycoplasma hyopneumoniae  antigen may be the antigen or antigens contains in one of the following vaccines: Ingelvac®MycoFlex (Boehringer Ingelheim Vetmedica Inc, St Joseph, Mo., USA), Porcilis M. hyo, Myco Silencer® BPM, Myco Silencer® BPME, Myco Silencer® ME, Myco Silencer® M, Myco Silencer® Once, Myco Silencer® MEH (all from Intervet Inc., Millsboro, USA) Stellamune  Mycoplasma  (Pfizer Inc., New York, N.Y., USA), Suvaxyn  Mycoplasma , Suvaxyn M. hyo, Suvaxyn MH-One (all formerly Fort Dodge Animal Health, Overland Park, Kans., USA (now Pfizer Animal Health). 
     The Circovirus vaccine may contain attenuated and/or inactivated porcine Circovirus, preferably type 2, particularly type 2 ORF2 protein. It is particularly preferable to use recombinantly expressed ORF2 protein of the Porcine Circovirus type 2, preferably expressed in and obtained from in vitro cell culture. Examples of ORF2 proteins of the Porcine Circovirus type 2 are described inter alia in International Patent Application WO2006-072065. These have proved particularly advantageous for effective vaccination. Moreover, the Circovirus vaccine may be one of the following vaccines, or the Circovirus antigen may be the antigen or antigens contained in one of the following vaccines: Ingelvac®CircoFLEX, (Boehringer Ingelheim Vetmedica Inc, St Joseph, Mo., USA), CircoVac® (Merial SAS, Lyon, France), CircoVent (Intervet Inc., Millsboro, Del., USA), or Suvaxyn PCV-2 One Dose® (Fort Dodge Animal Health, Kansas City, Kans., USA). 
     The Circovirus vaccine, if it contains the ORF2 protein, preferably contains between 2 μg and 150 μg, preferably between 2 μg and 60 μg, more preferably between 2 μg and 50 μg, more preferably between 2 μg and 40 μg, more preferably between 2 μg and 30 μg, more preferably between 2 μg and 25 μg, more preferably between 2 μg and 20 μg, more preferably between 4 μg and 20 μg, more preferably between 4 μg and 16 μg of ORF2 protein per dose to be administered. The Circovirus vaccine is preferably prepared or formulated so that 1 ml of the vaccine corresponds to a dose of 1. In particular, the Circovirus vaccine may contain ORF2 protein in amounts of more than 2 μg/ml, preferably more than 4 μg/ml and/or less than 150 μg/ml, preferably less than 60 μg/ml, 50 μg/ml, 40 μg/ml, 30 μg/ml or 25 μg/ml, particularly less than 20 μg/ml. This contributes to reliability of administration. 
     The  Mycoplasma  vaccine, if it contains inactivated  Mycoplasma  bacteria, preferably inactivated  Mycoplasma hyopneumoniae  bacteria, preferably contains between 10 3  and 10 9  colony forming units (CFU), preferably between 10 4  and 10 8  (CFU), more preferably between 10 5  and 10 6  (CFU) per dose to be administered, the corresponding CFU being adjusted before the inactivation of the bacteria. The  Mycoplasma  vaccine is preferably prepared or formulated so that 1 ml of the vaccine corresponds to a dose of 1. In particular, the  Mycoplasma  vaccine may contain more than 10 3  CFU/ml, preferably more than 10 4  CFU/ml, particularly more than 10 5  CFU/ml and/or less than 10 9  CFU/ml, preferably less than 10 8  CFU/ml, particularly less than 10 7  CFU/ml or 10 6  CFU/ml of inactivated  Mycoplasma  bacteria, preferably inactivated  Mycoplasma hyopneumoniae  bacteria, particularly before the inactivation of the bacteria. 
     At least one of the reactants and/or the vaccine or combined vaccine may contain an adjuvant, preferably a polymeric adjuvant, particularly carbomer. Preferably at least or precisely one of the two reactants, preferably both reactants, contain a quantity of adjuvant of 500 μg to 5 mg, preferably from 750 μg to 2.5 mg, more preferably about 1 mg of adjuvant per dose to be administered. The reactants are preferably prepared or formulated so that 1 ml of the respective reactant corresponds to a dose of 1. The use of an adjuvant, preferably a polymeric adjuvant, such as carbomer, for example, has proved advantageous in relation to the efficiency of immunization or the duration of the effect. However, the use of alternative and/or additional adjuvants is not ruled out. 
     According to another aspect of the present invention, the first and/or the second and/or the combination of the first and second container B 1 , B 2 , B 3  with the fluidic connection  2  provided may be configured for use in or with an injection device, and/or used therein. In particular, it is an injection device which can be reused repeatedly, for example an injection gun, a pressure injector and/or a self-filling syringe, of the kind used for vaccinating large herds of animals, for example. 
     The kit or container system B according to the invention may comprise such an injection device or may be associated with one. In particular, the removal opening E 1 , E 2  or another opening, a flange or other connecting or closing element of at least one of the containers B 1 , B 2  and/or of both containers B 1 , B 2  may be configured so as to allow direct use in or with the injection device. Moreover, the removal device, the opening, the flange or other connecting or closing element may be configured specifically for connection to a particular injection device. This can reduce the probability of incorrect use, particularly the wrong amounts of active substance or methods of administration. 
     An aspect of the present invention which may also be implemented independently further relates to an injection device with an inserted combination of at least two of the proposed containers B 1 , B 2 , B 3 , which are fluidically connected to one another with the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ according to the present invention. In particular, by means of the fluidic connection  2 , a mixture of the substances S 1 , S 2 , S 3  from the containers B 1 , B 2 , B 3  is formed and the injection device is set up for injecting the mixture of substances S 1 , S 2 , S 3 . 
     Further aspects of the present invention will be explained hereinafter with reference to another embodiment, detailing only the differences and special features compared with the embodiments described hereinbefore. The aspects can therefore be combined with the aspects described previously, and vice versa, unless this is specifically ruled out. Moreover, reference will be made to the previous explanations and definitions. 
     The embodiment described hereinafter with reference to  FIG.  22     ff . preferably relates to the variant described above in which the first connecting arrangement  3 A′ is deformable outside the opening region  4 A′ and is configured so that the deformation causes the first connecting arrangement  3 A′ to open in the opening region  4 A′. For further details, reference may be made to  FIGS.  5  to  13    and the related explanations. 
     According to an aspect of the present invention which can also be implemented independently, the first connecting arrangement  3 A′ comprises a preferably rigid, stiff and/or dimensionally stable closure device  23 , particularly a closure plate. The closure device  23  is preferably sealingly attached to a holding portion  25  by means of a fragile frangible point  24 , particularly a thin point. The opening region  4 A′ of the first connecting arrangement  3 A′ may thus be formed with or by the closure device  23  and/or frangible point  24 . 
     The aspects explained previously in connection with the fragility of the opening region  4 A′, particularly with regard to the material thickness and the like, can preferably be applied to or transferred to the frangible point  24 . The difference thus lies particularly in the fact that the opening region  4 A′ of the first connecting arrangement  3 A′ additionally comprises the closure device  23  which stabilizes or reinforces the opening region  4 A′ in a central portion or a portion surrounded by a film-shaped, brittle, unstable and/or fragile region in the form of the frangible point  24 . 
     The holding portion  25  preferably corresponds to the mouth-shaped portion  5 A′ of the first connecting arrangement  3 A′ and/or the mouth-shaped portion  5 A′ comprises the holding portion  25 . The related explanations in connection with the mouth-shaped portion  5 A′ may therefore be applied to the holding portion  25  as well, in an alternative or supplementary capacity. If necessary, the holding portion  25  can therefore also be designated a mouth-shaped portion  5  A′ or be wholly or partially formed thereby or vice versa. 
     Particularly preferably, the holding portion  25  is movable by deformation relative to the closure device  23 , so that the first connecting arrangement  3 A′ can be opened by tearing the frangible point  24 . It has advantageously been found that the use of a closure device  23  and the concomitant concentration of the force applied by the deformation on a fragile area (frangible point  24 ) surrounding the closure device  23  makes it possible to achieve a particularly reliable and simpler opening by means of deformation. 
       FIG.  22    shows an overview of the container system B, in which the containers B 1 , B 2  are fluidically connected to one another by means of the connecting arrangements  3 A′,  3 B′. For this purpose, the first connecting arrangement  3 A′ or its opening region  4 A′ and the second connecting arrangement  3 B′ or its opening region  4 B′ are shown open in each case. 
     For the following explanations, reference is additionally made to  FIGS.  23  to  26   , while  FIG.  23    shows a longitudinal section through the first container B 1  with the first connecting arrangement  3 A′ in an initial state with the opening region  4 A′ closed.  FIG.  24    shows a magnified detail of a partial region of the closure device  23  and of the holding portion  25  with the frangible point  24  between them. In the embodiment shown according to  FIG.  23    the opening region  4 A′ is covered by a preferably cap-shaped cover device  26 . The cover device  26  has been removed in the embodiment shown in  FIG.  25   .  FIG.  26    shows a perspective representation of the first connecting arrangement  3 A′ as part of the first container B 1  without the cover device  26 . 
     The closure device  23  is preferably configured and/or held by means of the frangible point  24  such that the closure device  23  is inclined as the holding portion  25  is deformed. 
     Preferably, the frangible point  24  or a surface or plane  27  formed or defined by the frangible point  24  is inclined relative to the central axes or axes of symmetry  9 . This enables or facilitates pushing, rotation and/or further inclination of the closure device  23  during the opening process or prevents blockade of the closure device  23  relative to the holding portion  25 . 
     During the opening process the closure device  23  may slide over the holding portion  25  as a result of the deformation of the holding portion  25 , particularly while being inclined or tilting. 
     The holding portion  25  preferably comprises a frame  28  or is of a frame-shaped construction. The closure device  23  is preferably inclined relative to the frame  28  in the initial state. As a result, the frame  28  and the closure device  23  are each partially offset from one another, with the result that an offset directly adjacent the frangible point  24  may form this or an offset region. The offset is preferably aligned in opposite directions on opposite sides. The advantage of the offset is that during deformation of the holding portion  25  the closure device  23  is able to slide along the frame  28  or tuck in behind it. This makes the opening process easier because blocking of the deformation of the holding portion  25  by the closure device  23  is prevented and as a result the opening of the opening region  4 A′ is made easier. 
     Preferably, particularly as a result of the step-shaped offset of the frame  28  relative to the edge of the closure device  23  adjacent the frangible point  24  and/or as a result of the inclination of the closure device  23  and/or the frangible point  24  relative to the central axis  9 , a shearing action of the closure device  23  relative to the frame  28  is made possible, or is achieved during deformation. Such a shearing action advantageously makes it possible to apply a strong mechanical stress to the frangible point  24 , in relation to the degree of deformation of the holding portion  25 , particularly by producing tensile and/or shear stresses, thus making the severing or tearing of the frangible point  24  easier. Overall, this provides a comfortable and reliable method of opening the opening region  4 A′ of the first connecting arrangement  3 A′. 
     According to a further aspect of the present invention the closure device  23  is formed in a ramp shape starting from the frangible point  24  provided on the edge thereof. This may be achieved by increasing the material thickness, preferably in relation to a surface or plane  27  defined by or extending through the frangible point  24 . Alternatively, or additionally the closure device  23  is formed in a ramp shape starting from the offset region. In this way it is possible to incline the closure device  23  increasingly as the deformation of the holding portion  25  progresses. The ramp-shaped portion of the closure device  23  can slide along the holding portion  25  and thereby produce an increasing inclination. 
     The closure device  23  itself preferably comprises a reinforcement  29 , in the embodiment shown in the form of ribs or some other added material or added thickness of material that will improve mechanical stability. This reinforcement  29  may be formed at the edge of the closure device  23  or may be configured like a ramp, starting from the frangible point  24  provided at the edge, particularly such that the closure device  23  is increasingly inclined as deformation progresses. 
     As may be seen for example in the perspective view in  FIG.  26   , the holding portion  25  is preferably non-round perpendicularly to the central axis or axis of symmetry  9 , particularly oval in shape, as explained previously in connection with  FIGS.  5  to  13   . The same also applies alternatively or additionally to the frangible point  24  and/or an encircling edge of the closure device  23  or such an edge adjoining the frangible point  24  and/or to the frame  28 . 
     The frangible point  24 , particularly the thin point, is preferably so fragile that deformation of the holding portion  25  can cause tearing of the frangible point  24  and hence opening of the connecting arrangement  3 A′. 
     In the embodiment shown the frangible point  24  is only ten microns thick, preferably less than 300 microns, more preferably less than 200 microns or less than 150 microns. The distance between the holding portion  25  and the closure device  23 , which is tightly bridged by means of the frangible point  24 , is preferably less than 3 mm, particularly preferably less than 2 or 1 mm, in the embodiment shown less than 0.5 mm. It is also preferable if the distance between the closure device  23  and holding portion  25  or the length of the frangible point  24  does not exceed, or only slightly exceeds, corresponding values in the entire area surrounding the closure device  23 . The frangible point  24  thus preferably has an at least substantially constant length and/or material thickness in its extent around the closure device  23 . The frangible point  24  thus preferably surrounds the closure device  23  at least substantially completely. 
     The holding portion  25  is preferably deformable by insertion in a deforming device  30  of at least a substantially complementary shape and subsequent rotation of the holding portion  25  relative to the deforming device  30  about the central axis and/or axis of symmetry  9 . In particular, the holding portion  25  is radially deformable in relation to and/or in the direction of the central axis and/or axis of symmetry  9 . 
       FIG.  27    shows a section through a second container B 2  with the second connecting arrangement  3 B′ and  FIG.  28    shows a magnified detail thereof.  FIG.  29    shows the second container B 2  with the cover device  6  removed and  FIG.  30    shows a perspective view of the second connecting arrangement  3 B′. 
     The deforming device  30  is particularly preferably formed by the second connecting arrangement  3 B′, particularly its mouth-shaped portion  5 B′. For this, reference is made to the corresponding explanation in connection with  FIGS.  5  to  13    and to the following explanations of the second connecting arrangement  3 B′ from the embodiment shown in  FIG.  22     ff.    
     The holding portion  25  of the first connecting arrangement  3 A′ is preferably in the shape of a neck, collar and/or tube with, and in particular by means of, a flexible deformable wall  31 . In the embodiment shown in  FIG.  22     ff . the wall  31  forms a preferably at least substantially conical shape converging towards the frame  28 , which may form the mouth-shaped portion  5 A′ in the present case. However, other solutions are also theoretically possible here. 
     It is also preferable that the holding portion  25 , particularly the frame  28 , has a piercing and/or cutting edge  32  or other severing element  7 . The piercing and/or cutting edge  32  is preferably attached to the frame  28 , formed by the frame  28 , particularly in one piece and/or by molding on. The piercing and/or cutting edge  32  is preferably formed by an at least substantially axially extending strip preferably forming a point. 
     The piercing and/or cutting edge  32  is preferably configured to open the second connecting arrangement  3 B′, particularly as a result of the opening region  4 B′ of the second connecting arrangement  3 B′ being perforated or pierced by means of the piercing and/or cutting edge  32 . Preferably, during an axial movement of the connecting arrangements  3 A′,  3 B′ to one another, the opening region  4 B of the second connecting arrangement  3 B′ is first of all pierced by the piercing and/or cutting edge  32  projecting axially outwards relative to the opening region  4 A′, particularly of the closure device  23 , and only afterwards can the opening region  4 A′ of the first connecting arrangement  3 A′ be opened by the rotation of the connecting arrangements  3 A′,  3 B′ relative to one another in the manner described. By comparison with the embodiment in  FIGS.  5  to  13   , however, in the present case the holding portion  25  or the mouth-shaped portion  5 A′ is configured to pierce the opening region  4 B′ of the second connecting arrangement  3 B′. In this respect, reference is made to the previous explanations for supplementary information. 
     In the present embodiment, by comparison with the previous embodiment, the piercing and/or cutting edge  32  is provided on the mouth-shaped portion  5 A′, as is also possible in the previous embodiment and advantageous for easier opening of the opening region  4 B′ of the second connecting arrangement  3 B′. 
     In the present embodiment, the opening region  4 B′ of the second connecting arrangement  3 B′ is closed off by an, in particular, at least substantially rigid, dimensionally stable and/or plate-shaped closure device  33 , particularly a closure plate or disc, which is preferably sealingly held on the mouth-shaped portion  5 B, particularly by means of a frangible point  34 . Other constructions are also theoretically possible here, for example as described in connection with  FIG.  7   . The use of the closure device  33 , in a similar manner to the closure of the first connecting arrangement  3 A′ with the closure device  23 , however, makes it easier to open the second connecting arrangement  3 B′ in the opening region  4 B′. 
     The piercing and/or cutting edge  32  preferably corresponds in its orientation and position to the frangible point  34  of the second connecting arrangement  3 B′, such that bringing the connecting arrangements  3 A′,  3 B′ together leads to the piercing and/or cutting edge  32  being applied to the frangible point  34 , as a result of which the frangible point  34  can be severed, starting at the initial point of application of the piercing and/or cutting edge  32 . Preferably, the connecting arrangements  3 A′,  3 B′ are correspondingly guided to one another. 
     The frame  28  and/or the piercing and/or cutting edge  32  preferably has a rounded and/or chamfered portion, so that when the piercing and/or cutting edge  32  acts on the frangible point  34  the frangible point  34  is partially spared, so that preferably an intact part of the frangible point  34  still holds the closure device  33  against the mouth-shaped portion  5 B′ after opening, particularly in the manner of a film hinge. This ensures that the closure device  33  is not detached and prevents blockage of one of the removal openings E 1 , E 2 . 
     In the embodiment shown, in the initial state, the closure device  33  is aligned with the mouth-shaped portion  5 B′ at least substantially perpendicular to the central axis or axis of symmetry  9 . It is certainly possible to have an inclined alignment, as with the closure device  23  of the first connecting arrangement  3 A′, but this is not absolutely necessary, as the second connecting arrangement  3 B′ is preferably opened primarily by the piercing and/or cutting edge  32  and not by deformation of the mouth-shaped portion  5 B′. 
     The mouth-shaped portion  5 B′ is preferably sufficiently stable in its construction and hold so that when the connecting arrangements  3 A′,  3 B′ are rotated after being inserted in one another, deformation takes place at least substantially or in any case predominantly in the region of the mouth-shaped portions  5 A′ or in the holding portion  25 . A certain deformation of the mouth-shaped portion  5 B′ and/or the deforming device  30 , of the second connecting arrangement  3 B′ is possible, however. 
     According to a further aspect of the present invention the container(s) B 1 , B 2  is or are (each) formed from a container blank BR 1 , BR 2  and the respective connecting arrangement  3 A′,  3 B′. The same may also apply to the previous embodiment. 
     In the embodiment shown the container blanks BR 1 , BR 2  are upper container or bottle parts, configured for connection to the respective connecting arrangement  3 A′,  3 B′ on a side or end remote from or opposite to the removal opening E 1 , E 2 . In particular, they are container blanks BR 1 , BR 2  without bases, the resulting open region being closed off during manufacture by means of the respective connecting arrangement  3 A′,  3 B′ to form the respective container B 1 , B 2 . 
     Container blanks BR 1 , BR 2  are thus particularly structures with a removal opening E 1 , E 2  and another open point which can be closed off by the respective connecting arrangement  3 A′,  3 B′. 
     Preferably, the respective connecting arrangement  3 A′,  3 B′ is tightly connected to a wall of the container blank BR 1 , BR 2  by material engagement, particularly preferably by welding, adhesive bonding, injection molding or by some other method. The connecting arrangements  3 A′,  3 B may consequently be used in all kinds of containers B 1 , B 2  or may also be used independently of containers B 1 , B 2 , for example in order to fluidically connect a container B 1 , B 2  to another structure such as a pipe, a connector or the like. However, the connection of containers B 1 , B 2 , B 3  to one another is particularly preferred. 
     Preferably, the (respective) connecting arrangement  3 A′,  3 B′ is configured to be connected to the container blank BR 1 , BR 2  so that a container B 1 , B 2  is formed. It is also preferable that the container blank BR 1 , BR 2  should have a wall  35 A′,  35 B′ with an open edge  36 A′,  36 B′, forming a receptacle for the connecting arrangement  3 A′,  3 B′, into which the respective connecting arrangement  3 A′,  3 B′ can be inserted and tightly connected to the container blank BR 1 , BR 2 . 
     In another aspect the present invention relates to a connecting system  1  with the first connecting arrangement  3 A′ comprising the holding portion  25  and the frangible point  24  and a second connecting arrangement  3 B′ comprising the deforming device  30  corresponding to the holding portion  25 , wherein the connecting arrangements  3 A′,  3 B′ can be inserted sealingly into one another and, as the connecting arrangements  3 A′,  3 B′ are rotated relative to one another, as a result of the deformation of the holding portion  25  by the deforming device  30 , the first connecting arrangement  3 A′ can be opened in order to produce the fluidic connection  2 . 
     In another aspect which may also be implemented independently, the present invention further relates to one or more containers B 1 , B 2 , B 3 , particularly bottles (each) having a connecting arrangement  3 A′,  3 B′ according to the present invention, preferably on a side or end remote from a container opening or removal opening E 1 , E 2 , another connecting arrangement  3 A′,  3 B′ or a base. 
     In another aspect which may also be implemented independently, the present invention further relates to a container system B with at least two containers B 1 , B 2 , B 3 , wherein a first container B 1  comprises the first connecting arrangement  3 A′ and a second container B 2 , B 3  comprises the second connecting arrangement  3 B′, which corresponds to the first connecting arrangement  3 A′. 
     The connecting arrangements  3 A′,  3 B′ are preferably configured as described hereinbefore. In particular, it is preferable for the first connecting arrangement  3 A′ to have the piercing and/or cutting edge  32  by means of which the second connecting arrangement  3 B′ can be opened. 
     Alternatively, or additionally the second connecting arrangement  3 B′ comprises the mouth-shaped portion  5 B′ or the deforming device  30 , for opening the first container B 1  by means of the first connecting arrangement  3 A′ by deformation of the holding portion  25  or of the mouth-shaped portion  5 A′. 
     It is also preferable that the connecting arrangements  3 A′,  3 B′ should enable the formation of the fluidic connection  2  by mutual opening, the first connecting arrangement  3 A′ opening the second connecting arrangement  3 B′ and the second connecting arrangement  3 B′ opening the first connecting arrangement  3 A′, thus forming the fluidic connection  2 . 
     In another aspect of the present invention which may also be implemented independently, the connecting arrangements  3 A′,  3 B′ are used to prepare a mixture of substances, preferably a medicament, particularly a vaccine or combined vaccine, to produce a fluidic connection  2  and/or to mix starting materials or substances S 1 , S 2  which have been stored separately. 
     The invention further relates to a method, which may also be implemented independently, for producing one of the connecting arrangements  3 A′,  3 B′ or the connecting system  1  and/or a container B 1 , B 2 , B 3 , in which the closure device  23 ,  33 , the frangible point  24 ,  34  and the holding portion  25  or the mouth-shaped portion  5 A′,  5 B′ are injection molded in a common step. This has proved advantageous in terms of reliable production of the frangible point  24 ,  34 . 
     In the method, it is also preferable if, in a container blank BR 1 , BR 2  having an open end, particularly a bottle blank with a removal opening E 1 , E 2  in addition to the open end, the open end is sealed off by the separately produced connecting arrangement  3 A′,  3 B′. 
     The connecting arrangement  3 A′,  3 B′ preferably comprises a collar-shaped and/or tubular portion  37 A′,  37 B′ which delimits the (respective) connecting arrangement  3 A′,  3 B′ radially outwards and corresponds to the wall  35 A′,  35 B′ of the respective container B 1 , B 2  or container blank BR 1 , BR 2 , in order to be inserted therein and connected to the container blank BR 1 , BR 2 . 
     Another aspect of the present invention which may also be implemented independently relates to the sealing concept, based on a combination of the connecting arrangements  3 A′,  3 B′ with one another, or of one of the connecting arrangements  3 A′,  3 B′ with a preferably cap-shaped cover device  6 ,  26 . 
     It is provided that a container B 1 , B 2 , B 3  is provided with a connecting arrangement  3 A′,  3 B′ for producing a fluidic connecting arrangement  2  of the container B 1 , B 2 , B 3  with another container B 1 , B 2 , B 3 . In an initial state the connecting arrangement  3 A′,  3 B′ may be fluidically sealed in an opening region  4 A′,  4 B′ and can be opened in order to form the fluidic connection  2 . The opening region  4 A′,  4 B′ is covered with a cap-shaped cover device  6 ,  26  and/or another connecting arrangement  3 A′,  3 B′. This aspect thus relates particularly to an individual container B 1 , B 2 , B 3  or a connecting arrangement therefor, of the container system B combined with the cap-shaped cover  6 ,  26  and/or the (corresponding) connecting arrangement  3 A′,  3 B′. 
     In another aspect which may also be implemented independently, it is envisaged that the cover device  6 ,  26  or the other connecting arrangement  3 A′,  3 B′ is sealingly held on the proposed container B 1 , B 2 , B 3 , thus forming a sealed chamber  38 A,  38 B,  38 C. Moreover, the proposed container B 1 , B 2 , B 3  comprises a sealing arrangement  39  surrounding the opening region  4 A′,  4 B′ thereof, which seals off a volume  40 A,  40 B,  40 C of the chamber  38 A,  38 B,  38 C in direct contact with the opening region  4 A,  4 B′. Particularly preferably, the sealing arrangement  39  seals off the inner volume  40 A,  49 B,  40 C from an outer volume  41 A,  41 B,  41 C of the chamber  38 A,  38 B,  38 C. This advantageously covers the opening region  4 A′,  4 B′, particularly by means of a double closure. This enhances the barrier preventing the ingress of substances, particularly germs. 
     It is provided, in particular, that foreign substances can only reach the inner volume  40 A,  40 B,  40 C by passing through the outer volume  41 A,  41 B,  41 C. The sealing arrangement  39  is preferably mechanically decoupled from the environment by an outer seal of the cover device  6 ,  26 , so that any force acting on the cover device  6 ,  26  may affect the tight seal of the outer volume  41 A,  41 B,  41 C, but the inner volume  40 A,  40 B,  40 C will remain sealed even in such a case, preferably in airtight manner, particularly in germproof or bacteria-proof manner. In this way it is possible to guarantee a sterile environment at the opening region  4 A′,  4 B′. 
     Alternatively, or additionally the sealing arrangement  39  seals off the inner volume  40 A,  40 B,  40 C surrounding the opening region  4 A′,  4 B′ by means of the cover device  6 ,  26  or the other connecting arrangement  3 A′,  3 B′ when there is uninterrupted movement of the cover device  6 ,  26  or the other connecting arrangement  3 A′,  3 B′ relative to the connecting arrangement  3 A′,  3 B′ of the proposed container B 1 , B 2 , B 3 . In this way, during the process of inserting the connecting arrangements  3 A′,  3 B′ into one another and/or during the assembly or removal of the cover device(s)  6 ,  26 , the opening region  4 A′,  4 B′ can be protected from the ingress of foreign substances, particularly germs. 
     It is particularly preferable to combine the two aspects, i.e. to form the chamber  38 A,  38 B,  38 C, which is divided by the sealing arrangement  39  into an inner volume  40 A,  40 B,  40 C and an outer volume  41 A,  41 B,  41 C, the sealing arrangement  39  being configured to prevent the ingress of foreign substances, particularly germs, into the inner volume  40 A,  40 B,  40 C, during, in particular, axial movement of the cover device  6 ,  26  or other connecting arrangements  3 A′,  3 B′. 
     The sealing arrangement  39  preferably comprises sealing portions  42 A,  42 B,  43 A,  43 B corresponding to one another, a first sealing portion  42 A,  42 B being associated with the connecting arrangement  3 A′,  3 B′ and a second sealing portion  42 A,  42 B,  43 A,  43 B being arranged on the cover device  6 ,  26  and/or on the other connecting arrangement  3 A′,  3 B′, particularly being formed in one piece therewith. 
     The sealing portions  42 A,  42 B,  43 A,  43 B preferably comprise sealing surfaces  44 A,  44 B,  45 A,  45 B corresponding to one another, which abut closely on one another when the cover device  6 ,  26  is placed on the connecting arrangement  3 A′,  3 B′ or the connecting arrangements  3 A′,  3 B′ are fitted into one another. 
     The sealing surfaces  44 A,  44 B,  45 A,  45 B preferably have a similar shape in cross-section (perpendicular to the central axis or axis of symmetry  9 ) and/or are round and/or rotationally symmetrical to the common axis of symmetry and/or central axis  9 . 
     Preferably, the sealing portions  44 A,  44 B,  45 A,  45 B are configured and/or correspond to one another such that it is possible to rotate the cover device  6 ,  26  and/or the other connecting arrangement  3 A′,  3 B′ relative to the container B 1 , B 2 , B 3 . 
     Preferably, one of the connecting arrangements  3 A′,  3 B′ comprises a sealing surface  44 A,  44 B, which corresponds to both the sealing surface  44 A,  44 B of the other connecting arrangement  3 A′,  3 B′ and to the sealing surface  45 A,  45 B of the cover device  6 ,  26  corresponding to the connecting arrangement  3 A′,  3 B′. The sealing arrangement  39  may thus be formed on the basis of a connecting arrangement  3 A′,  3 B′ both with the corresponding cover device  6 ,  26  and with the other connecting arrangement  3 A′,  3 B′. In this way it is possible to obtain a seal over the cover device  6 ,  26  during transporting and over the other connecting arrangement  3 A′,  3 B′ during use, using the same means or re-using the same means. 
     Another aspect of the present invention which may also be implemented independently relates to the connecting system  1  for producing the fluidic connection  2  between the containers B 1 , B 2 , B 3  and/or a container B 3 , the connecting system  1  or the container B 3  having at least two connecting arrangements  3 A′,  3 B′ configured to produce the fluidic connection  2 , namely a first connecting arrangement  3 A′ and a second connecting arrangement  3 B′, which are each fluidically sealed in an initial state or fluidically close off the container B 1 , B 2 , B 3  and can be opened in an opening region  4 A′,  4 B′ in order to produce the fluidic connection  2 . 
     In another aspect it is provided that the connecting arrangements  3 A′,  3 B′ form the sealed chamber  38 C and comprise the sealing arrangement  39 , while a volume  40 C in direct contact with the opening regions  4 A′,  4 B′ is sealed off from a volume  41 C of the chamber  38 C separated from the opening regions  4 A′,  4 B′ by means of the sealing arrangement  39 . 
     Alternatively or additionally the connecting system  1  comprises a sealing arrangement  39  which uninterruptedly seals off a volume  40 C in direct contact with the opening regions  4 A′,  4 B′ as the connecting arrangements  3 A′,  3 B′ are moved relative to one another. 
     It is also preferable if the connecting arrangement  3 A′,  3 B′ comprises at least two positions for connection to one another, which are occupied one after the other in terms of time and location when the connecting arrangements  3 A′,  3 B′ are pushed or fitted into one another. In the first connecting position a non-releasable connection is made between the connecting arrangements  3 A′,  3 B′ and the fluidic connection  2  is only produced, or able to be produced, in the second connecting position. For further details, reference may be made to the previous embodiments. 
     It is particularly preferable that the sealing arrangement  39  seals or closes off the inner volume  40 C without interruption in the first connecting position, in the second connecting position and between the first and second connecting positions and/or seals or separates the inner volume  40 C from the outer volume  41 C without interruption. 
     For further details of the connecting system  1  in connection with the sealing arrangement  39 , reference is made to the previous discussion in particular with regard to the sterile or sterilizable covering in connection with, e.g.,  FIGS.  16 ,  17  and  20    and/or in connection with the proposed container B 1 , B 2 , B 3  with the sealing arrangement  39 . 
     Another aspect of the present invention which may also be implemented independently relates to a connecting arrangement  3 A′,  3 B′ and/or a container B 1 , B 2 , B 3  having this connecting arrangement  3 A′,  3 B′, wherein the opening region  4 A′,  4 B′ of the connecting arrangement  3 A′,  3 B′ is fluidically closed in an initial state and can be opened to form the fluidic connection  2 . In this aspect the connecting arrangement  3 A′,  3 B′ comprises a cover device  6 ,  26 , which can preferably be latched to the container B 1 , B 2 , B 3  or the connecting arrangement  3 A′,  3 B′ and/or is in the form of a cap and/or is removable, and which covers the opening region  4 A′,  4 B′. 
     The cover device  6 ,  26  according to this aspect preferably comprises a support portion  46  which corresponds to the opening region  4 A′,  4 B′ and is directly or so closely adjacent to the opening region  4 A′,  4 B′ that a force FS acting on the opening region  4 A′,  4 B′ in the direction of the support portion  46  is absorbed by the contact of at least part of the opening region  4 A′,  4 B′ on the support portion  46  such that opening of the opening region  4 A′,  4 B′ is prevented. 
     In the embodiment according to  FIG.  23    the cover device  26  closes off the connecting arrangement  4 A′ in corresponding manner. The support portion  46 A here is arranged directly adjacent the closure device  23 . When a force FS acts on the closure device  23  from the interior of the container B 1 , for example when the container B 1  flies open in the region of the cover device  26  in the event of being overturned or the like, and thus, the substance S 1  present in the container suddenly exerts the force FS on the opening region  4 A′, particularly the closure device  23 , the closure device  23  can be supported by the support portion  46 A, while the force FS is in any case partially absorbed, caught and/or diverted by the support portion  46 A. In this way the opening region  4 A′ is protected from accidental opening, particularly by impact or overturning. 
     A corresponding mechanism of activity is preferred with reference to  FIG.  27    by means of the support portion  46 B of the cover device  6  combined with the opening region  4 B′ or the closure device  33 . In addition, the protection against opening provided by the support portion  46 A,  46 B as described can also be applied to the previous embodiments and aspects, by correspondingly replacing the cover device  6  or the closure  14  with cover devices  6 ,  26  which have a support portion  46 A,  46 B. 
     The support portion  46  is preferably at least substantially held, or capable of being held, on a wall of the container B 1 , B 2 , B 3  and/or on the connecting arrangement  3 A′,  3 B′. In this way it is possible to divert a force FS introduced into the support portion  46 A,  46 B. Particularly preferably, the support portion  46 A is at least substantially rigidly connected to the mouth-shaped portion  5 A′,  5 B′ or holding portion  25  by means of the connecting arrangement  3 A′,  3 B′ and/or the container B 1 , B 2 , B 3 , by virtue of its construction or by mechanical means. 
     The opening region  4 A′,  4 B′ is thus preferably held on the container B 1 , B 2 , B 3  or on the wall of the container B 1 , B 2 , B 3  via the mouth-shaped portion  5 A′ or the holding portion  25  and the support portion  46 A,  46 B is held at least substantially rigidly on the same container B 1 , B 2 , B 3  or on the same wall of the container B 1 , B 2 , B 3 . Thus, the force FS directed onto the opening region  4 A′,  4 B′ or the closure device  23 ,  33  in the direction of the support portion  46 A,  46 B or outwardly in relation to the container volume can be absorbed and diverted by the support portion  46 A,  46 B. As a result, the force FS does not have to be diverted through or via the frangible point  24 ,  34 , or not solely through or via the frangible point  24 ,  34 . By removing the load from the frangible point  24 ,  34  in the event of any forces FS being exerted, the respective connecting arrangement  3 A′,  3 B′ is prevented from accidental opening. 
     The support portion  46 A,  46 B preferably corresponds to the closure device of the respective opening region  4 A′,  4 B′, in particular to the respective closure device  23 ,  33 , and/or is arranged adjacent thereto. The support portion  46 A,  46 B may form a plateau which is configured and/or aligned to be at least substantially parallel and/or corresponding to a side of the closure device  23 ,  33  facing the support portion  46 A,  46 B. It is also preferable that a movement of the closure device  23 ,  33  towards the support portion  46 A,  46 B leads to flat contact and/or contact that counteracts an inclination of the closure device, particularly in connection with forces exerted on the closure device by impact or inversion. 
     The support portion  46 A,  46 B is preferably formed by the base of an indentation  47  or receptacle  13  of the cover device  6 ,  26 , which is accessible from outside when mounted on or connected to the container B 1 , B 2 , B 3  or the connecting arrangement  3 A′,  3 B′. With regard to the receptacle  13  reference is also made to the description of the previous embodiments, for supplementary information. In particular, it may be envisaged that the receptacle  6 , indentation  26  or recess corresponds to a removal opening E 1 , E 2  or a bottle neck F 1 , F 2  of the container B 1 , B 2 , B 3 , so that the latter can be accommodated in the receptacle  6 , the indentation  26  or the recess, particularly for transporting and/or as a support foot. 
     The cover device  6  preferably comprises rib-shaped reinforcing elements  48 , which preferably assist with the supporting of the support portion  46 B or stabilize the support portion  46 B. Alternatively or additionally the reinforcing elements  48  correspond to the bottle neck F 1 , F 2  so as to accommodate, hold and/or stabilize it. In principle, the cover device  26  may also comprise corresponding or similar reinforcing elements  48 , even though they are not provided in this embodiment. 
     The support portion  46 A,  46 B is preferably supported by a sloping or at least substantially conical strip  49  against movement or deformation in axial directions or directions along the central axis or parallel thereto and/or the axis of symmetry  9 . 
     It is also preferable that the cover device  6 ,  26  is sealed onto the container and/or the connecting arrangement  3 A′,  3 B′ by means of the sealing arrangement  39 . The sealing device  39  preferably closes off a side of the support portion  46 A,  46 B facing the opening region  4 A′,  4 B′. Alternatively or additionally the sealing arrangement  39  is provided on a wall of the container B 1 , B 2 , B 3  provided, in addition to the sealing and/or latching mounting of the cover device  6 ,  26 . In this way, a chamber  38 A,  38 B, the inner volume  40 A,  40 B and/or volumes  40 A,  40 B,  41 A,  41 B separated from one another may be formed within the cover device(s)  6 ,  26  that are, or may be, attached to the container B 1 , B 2 , B 3  or the connecting arrangement  3 A′,  3 B′. 
     In another aspect which may also be implemented independently, the present invention further relates to the cap-shaped cover device  6 ,  26  as such and/or a combination thereof with a connecting arrangement  3 A′,  3 B′ in order to form a fluidic connection  2 , particularly between containers B 1 , B 2 , B 3 , the cover device  6 ,  26  having a side wall  50 A,  50 B and a base MA, MB which adjoins the side wall  50 A,  50 B. 
     On the side wall  50 A,  50 B is provided a holding device for releasably holding the cover device  6 ,  26  by interlocking and/or frictional engagement. In particular, this is one or more regions configured to seal and/or otherwise attach by interlocking and/or frictional engagement one or more, preferably one, encircling connection to the container B 1 , B 2 , B 3 , particularly without interruption, in the form of a bead or by some other means. 
     Preferably, the base  50  comprises a receptacle  13 , indentation  47  or recess into which a bottleneck-shaped removal opening E 1 , E 2  of the container B 1 , B 2 , B 3  can be inserted. 
     Alternatively or additionally, a base region of the receptacle  13 , indentation  47  or recess directed to the opening of the cover device  6 ,  26  comprises a plateau-shaped support portion  46 A,  46 B for supporting an opening region  4 A′,  4 B′ of a connecting arrangement  3 A′,  3 B′, a container B 1 , B 2 , B 3  or a part thereof. 
     Alternatively or additionally the base  51 A,  51 B of the cover device  6 ,  26  comprises an encircling strip-shaped sealing portion  43 A,  43 B which is configured to form a plurality of closed-off volumes  40 A,  40 B,  40 C,  41 A,  41 B,  41 C and/or to subdivide a chamber  38 A,  38 B and/or to support the base  51 A,  51 B. 
     The support portion  46 A,  46 B is preferably supported or strengthened by, in particular, rib-shaped reinforcing elements  48 , preferably so that the cover device  6 ,  26  is stiffened for diverting a force FS acting on the support portion  46 A,  46 B into a wall of the container B 1 , B 2 , B 3 . 
     In another aspect which may also be implemented independently the invention relates to the use of the cap-shaped cover device  6 ,  26  comprising the support portion  46 A,  46 B, which is arranged immediately adjacent to or at such a small spacing from an opening region  4 A′,  4 B′ of a container B 1 , B 2 , B 3  that a force FS acting on the opening region  4 A′,  4 B′ in the direction of the support portion  46 A,  46 B is absorbed by the flat contact of at least part of the opening region  4 A′,  4 B′ with the support portion  46 A,  46 B, in order to protect against accidental opening under the effect of external forces, preferably forces of acceleration, particularly as a result of impact on or overturning of the container B 1 , B 2 , B 3  that is or may be connected to the cover device  6 ,  26 , and/or connecting arrangement  3 A′,  3 B′, which is provided for the container B 1 , B 2 , B 3  or forms a part thereof. 
     With reference to  FIGS.  31  to  34    it will be explained once again, in connection with the present embodiment, how the containers B 1 , B 2 , B 3  are connected to one another by means of the first and second connecting arrangements  3 A′,  3 B′ shown by way of example in  FIG.  26    and  FIG.  30    in order to form the fluidic connection  2 . The procedure corresponds at least substantially to the procedure already described in connection with  FIGS.  5  to  13    or vice versa. 
     Preferably, first of all the cover devices  6 ,  26  are taken off, thereby exposing the connecting arrangements  3 A′,  3 B′. A cover device  6  may act as a stand. 
     The connecting arrangements  3 A′,  3 B′ are then brought axially closer to one another and inserted in one another, as shown by way of example in  FIGS.  31  to  33   . 
     Optionally, a preliminary latching stage shown in  FIG.  32    is reached as the first connecting position, in which the connecting arrangements  3 A′,  3 B′ or their opening regions  4 A′,  4 B′ still are or remain closed, the connecting arrangements  3 A′,  3 B′ or containers B 1 , B 2 , B 3 , however, are already held on one another, particularly by interlocking engagement, particularly non-releasably. For details of this, reference may be made to corresponding explanations of the previous embodiments. 
       FIG.  33    shows how the first connecting arrangement  3 A opens the opening region  4 B′ of the second connecting arrangement  3 B′, in this case preferably with the piercing and/or cutting edge  32  or some other severing element  7 . For this, the piercing and/or cutting edge  32  is applied axially to the frangible point  34  which holds the closure device  33 . As movement continues, the frangible point  34  is severed, particularly cut by means of the piercing and/or cutting edge  32  or torn. This therefore initially opens the opening region  4 B′ of the second connecting arrangement  3 B′. 
     In the following step the connecting arrangements  3 A′,  3 B′ or containers B 1 , B 2 , B 3  are rotated relative to one another about the common central axis or axis of symmetry  9 , as a result of which the holding portion  25  or the mouth-shaped portion  5 A′ of the first connecting arrangement  4 A′ is deformed and consequently the opening region  4 A′ of the first connecting arrangement  3 A′ is also opened, as shown in  FIGS.  22  and  34    in a final opening position. 
     The connecting arrangements  3 A′,  3 B′ are preferably connectable to one another by a bayonet-type action, in which an at least substantially or purely axial movement along the central axis or axis of symmetry  9  after the connecting arrangements  3 A′,  3 B′ have been pushed one inside the other is supplemented by a rotational movement of the connecting arrangements  3 A′,  3 B′ to one another about the central axis or axis of symmetry  9 . 
     This bayonet-type movement is preferably guided by the connecting arrangements  3 A′,  3 B′. In particular, as can be seen for example in the perspective representations of the first connecting arrangement  3 A′ in  FIG.  26    and the second connecting arrangement  3 B′ in  FIG.  30   , corresponding guide devices or guides  18 A,  18 B are provided, which preferably guide the bayonet-type movement described above. In particular, the first connecting arrangement comprises a strip-shaped guide device or guide  18 A, which preferably extends at least substantially in or along a plane perpendicular to the central axis or axis of symmetry  9 . The guide device or guide  18  B of the second connecting arrangement  3 B′ is preferably of corresponding, preferably complementary construction. It may comprise a guide groove in which the corresponding guide device or guide  18 A can be guided. 
     The guide devices or guides  18 A,  18 B may also be configured to pre-define an alignment about the central axis or axis of symmetry  9  as the connecting arrangements  3 A′,  3 B′ are brought towards each other. This alignment is preferably selected so that the opening regions  4 A′,  4 B′, which are oval, for example, in the embodiments shown, correspond to one another or are located in a similar orientation to one another. 
     The guide means or guides  18 A,  18 B are preferably configured to prevent rotation of the connecting arrangements  3 A′,  3 B′ about the central axis or axis of symmetry  9  by interlocking engagement while the connecting arrangements  3 A′,  3 B′ are being moved towards one another. As soon as the connecting arrangements  3 A′,  3 B′ have been inserted in one another, particularly thereby opening the opening region  4 B′ of the second connecting arrangement  3 B′, the guide devices  57 A,  57 B enable rotary movement of the connecting arrangements  3 A′,  3 B′ relative to one another about the common central axis or axis of symmetry  9 . This rotation leads to the above-mentioned deformation of the mouth-shaped portion  5 A′ or holding portion  25  of the first connecting arrangement  3 A′ and consequently to the opening of the opening region  4 A of the first connecting arrangement  3 A, thus forming the fluidic connection  2 . 
     The guide devices or guides  18 A,  18 B are preferably also embodied to block the relative position of the connecting arrangements  3 A′,  3 B′ in the axial direction, i.e. in the direction of the central axis or axis of symmetry  9 , particularly by interlocking engagement, by or after rotation of the connecting arrangements  3 A′,  3 B′ relative to one another. 
     Alternatively or additionally, securing means may be provided which prevent reverse rotation. This ensures that after the fluidic connection  2  has been produced the connecting arrangements  3 A′,  3 B′ cannot be moved apart again, particularly in order to guarantee the sterility of the fluidic connection  2 . 
     In another aspect which may also be implemented independently the invention relates to a container system B with two containers B 1 , B 2 , B 3 , B 4  which are fluidically separated from one another in an initial state and are fluidically connectable to one another by a movement of the containers B 1 , B 2 , B 3 , B 4  relative to one another, while in an initial state a securing device  52  blocks the, in particular, partially and/or initially axial movement of the containers B 1 , B 2 , B 3 , B 4  or their connecting arrangements  3 A′,  3 B′ relative to one another. 
     In the embodiment shown in  FIG.  35    a first container B 1  is shown by way of example with a further container B 4  and a securing device  52 . The further container B 4  has only one possible access, in the embodiment shown, which is formed by the second opening device  4 B′. However, other solutions are also possible, for example using the containers B 2 , B 3  described hereinbefore. 
       FIG.  35    shows the securing device  52  in the initial state, in which the containers B 1 , B 4  are not connected to one another. In this initial state the securing device  52  prevents movement of the containers B 1 , B 4  relative to one another, as required for opening or production of the connection between the containers B 1 , B 4 . In the present instance, the securing device  52  braces the containers B 1 , B 4  against one another, thus preventing the containers from moving axially towards one another. 
       FIG.  36    shows a magnified detail from the embodiment according to  FIG.  35   , in which the securing device  52  is activated or actuated. In this state the containers B 1 , B 4  are free to move relative to one another so that the fluidic connection  2  can be formed. For this it is particularly preferable for the opening regions  4 A,  4 B,  4 A′,  4 B′ to be opened on the basis of the connecting arrangement  3 A,  3 A′,  3 B,  3 B′ described hereinbefore by an initially axial or transitory and then rotary movement of the containers B 1 , B 4  relative to one another. 
       FIG.  37    shows magnified detail from the embodiment according to  FIG.  35    in a state after the relative movement has taken place. 
       FIG.  38    shows the securing device  52  in perspective view. 
     For the present aspect it is preferable if the containers B 1 , B 4  can be connected to one another by means of the proposed connecting arrangements  3 A′,  3 B′. In principle, however, other connecting methods may also be considered. 
     The container system B preferably comprises a receptacle  53 , particularly a pocket, for the securing device  52 , into which the securing device  52  can be received, particularly by pushing it in, as a result of or during the relative movement. 
     In the embodiment shown, in order to open the second connecting arrangement  3 B′, in particular, the connecting arrangements  3 A′,  3 B′ are moved axially relative to one another. This relative axial movement is prevented by the securing device  52  in an initial state and can be permitted by the securing device  52 . 
     The receptacle  53  is preferably provided behind a wall  35 A′,  36 A′ of one of the containers B 1 , B 4  and/or behind a collar-shaped and/or tubular portion  37 A′,  37 B′ of one of the connecting arrangements  3 A′,  3 B′, viewed from the outside. In the embodiment shown this wall is a wall of the container B 1 , which preferably forms a tubular or collar-shaped extension of a wall of the container B 1  delimiting the inner chamber, more particularly is aligned therewith. 
     In the embodiment shown the receptacle  53  is formed between the wall  35 A′,  36 A′ or collar-shaped portion  37 A,  37 B and the mouth-shaped portion  5 A′,  5 B′ or opening region  4 A′,  4 B′ of the container B 1 . Alternatively, or additionally, however, this may also be the case with other containers B 2 , B 3 , B 4 . 
     The container system B is preferably configured so that, during or as a result of or after actuation, the securing device  52  can protrude into or be aligned with the receptacle  53  in the axial direction based on the central axis and/or axis of symmetry  9  of the container system B. 
     It is also preferable that the securing device  52  is arranged in the starting position between edges  36 A′,  36 B′ of the containers B 1 , B 2 , B 3 , B 4  or connecting arrangements  3 A′,  3 B′, that are, in particular, opposite one another or correspond to one another, such that the edges  36 A′,  36 B′ are supported on one another by means of the securing device  52 . 
     The securing device  52  is preferably at least partially deformable, as a result of which the relative movement can be allowed. In particular, it is provided that by actuation of the securing device  52  an interlocking engagement can be undone, so that the containers B 1 , B 2 , B 3 , B 4  are no longer supported on one another, thus allowing relative movement to take place. 
     In the embodiment shown the securing device  52  is ring-shaped or annular, particularly formed by a ring, particularly a securing ring, or comprises one such, which is at least partially deformable or deformable in certain areas to release the connection. However, this is not essential and can also be achieved by some other method, although the use of a ring has advantages from the point of view of manufacturing and assembly. 
     The securing device  52  preferably comprises at least one, preferably flap-shaped or wing-shaped, blocking member  54  or is formed thereby. In a starting position the blocking member  54  blocks the movement of the connecting arrangements  3 A′,  3 B′ relative to one another by interlocking engagement. Moreover, the blocking member  54  is preferably deformable and/or depressible, so as to release the blockade and permit the relative movement. 
     In the embodiment shown the blocking member  54  or the blocking members  54  comprise(s) an edge  55  that forms the interlocking engagement and is movable, preferably deformable, at least substantially in the radial direction (with respect to or in the direction of the central axis or axis of symmetry  9 ) in order to release the blockade. In particular, the blocking member  54  is molded on at one end, formed in one piece with the securing device  52  and/or of wing-shaped configuration. 
     The receptacle  53  preferably corresponds to the shape of the securing device  52  or vice versa, and may thus comprise, or be formed by, a cavity or a pouch, which is particularly also ring-shaped or annular, in complementary manner to the securing device  52 . This cavity or pouch preferably comprises an opening towards the securing device  52  or towards the connecting arrangement  3 A′,  3 B′ opposite the receptacle  53 . 
     The securing device  52  is preferably formed of plastics, particularly a thermoplastic material. The securing device  52  may thus be a plastics ring. The blocking members  54  are preferably elastically deformable. Alternatively, release may also be effected by plastic deformation of the blocking members  54 . 
     In the initial state the securing device  52  is preferably arranged between the containers B 1 , B 2 , B 3 , B 4  in such a way that relative movement in the axial direction in relation to the central axis and/or axis of symmetry  9  of the container system B is blocked and by partial deformation of the securing device  52  radially in the direction of the central axis and/or axis of symmetry  9  of the container system B the relative movement can be freed up. 
     The securing device  52  preferably cannot be taken off and/or removed. Instead, the securing device  52  is received in the receptacle  53  during or after actuation and advantageously therefore does not result in a separate part that has to be disposed of separately, thus improving the handling and operational reliability. 
     In the embodiment shown the securing device  52  is rotatable, particularly mounted to be rotatable about the central axis and/or axis of symmetry  9 . The securing device  52  is held on a tapered portion and/or by interlocking engagement on the container system B. 
     In another aspect which may also be implemented independently the invention relates to a method of preparing a mixture of substances, particularly a vaccine, in which starting substances in the form of a first substance S 1  and a second substance S 2  are provided separately from one another in two fluidically connectable containers B 1 , B 2 , B 3 , B 4  and the containers B 1 , B 2 , B 3 , B 4  are fluidically connectable by movement relative to one another, preferably an axial relative movement with respect to a central axis and/or axis of symmetry of the container system B. 
     Preferably, during the process, the receptacle  53  is provided and the securing device  52  is arranged or formed between the containers B 1 , B 2 , B 3 , B 4 , blocking the movement of the containers B 1 , B 2 , B 3 , B 4  relative to one another in the initial state. In the process the securing device  52  is actuated and the securing device  52  is pushed into the receptacle  53  as a result of the actuation and/or the relative movement. 
     In the embodiment shown the securing device  52  is arranged, by way of example, between the first container B 1  and the fourth container B 4 . However, these may theoretically also be replaced by other types of container, particularly as described hereinbefore. Thus, during the formation of the receptacle  53 , the securing device  52  can theoretically also be used in the first connecting position according to  FIG.  32    in the same way as in the embodiment according to  FIGS.  22  to  33   . 
       FIG.  37    shows a magnified detail in the region of the securing device  52  and the receptacle  53 , in which the relative movement has taken place. As a result, the securing device  52  or the blocking member  54  or the blocking members  54  have each been pushed partially or at least substantially into the receptacle  53 . In particular, the edge  55  has been pushed into the receptacle  53 . Preferably, this prevents the securing device  52  from entering into another interlocking engagement. In the embodiment shown the securing device  52  is arranged in the receptacle  53  between a tubular or apron-shaped extension of the wall  35 A′ of the first container B 1  and the first connecting arrangement  3 A′. 
       FIG.  38    shows a schematic perspective view of the proposed securing device  52  on its own. This Figure clearly shows the wing-shaped blocking members  54  which are formed in the manner of film hinges or are hinged to the securing device  52  by means of a film hinge-shaped connection. In the embodiment shown in  FIG.  39   , the pivot axis of the blocking member  54  is at least substantially in a plane formed by the securing device  52 . 
       FIG.  39    shows the schematic section through a container system B with a securing device  52  according to a second embodiment. The second embodiment functionally resembles the first embodiment and therefore reference is made to the foregoing description relating to  FIGS.  35  to  38    for further details. Therefore, only the differences from the previous embodiment will be explained hereinafter. 
       FIG.  39    shows the container system B or the securing device  52  in a starting or blocking position. In this position, the blocking member  54  acts between the containers B 1 , B 4 , so that they are supported on one another and in this way prevent the relative movement. 
       FIG.  40    shows the container system B with the securing device  52  actuated, while the relative movement is enabled. For this, the blocking member or members  54  are deformed or displaced such that they or the securing device  52  can be accommodated in the receptacle  53 , particularly by pushing them into it. 
       FIG.  41    shows the container system B during or after the relative movement or a part thereof, in the course of which, or as a result of which, the securing device  52  has been pushed into the receptacle  53 . 
       FIG.  42    shows the securing device  52  of the second embodiment in perspective view on its own. One or more blocking members  54  are of wing-shaped configuration. The blocking members  54  in the initial state project at least substantially tangentially along a circumferential line of the securing device  52  or container B 1 , B 4 . In other words the blocking member  54  can be bent about one or more axes extending at least substantially parallel to the central axis or axis of symmetry  9  and/or can be deformed by winding it into a shape which corresponds to the shape of the receptacle  53  or permits the relative movement. 
     The objective in both embodiments is to achieve unlocking by forming the blocking member  54  into a shape and/or bringing it into a position in which the securing device  52  corresponds to the receptacle  53  and in which relative movement is made possible, so that the securing device  52  can be pushed into the receptacle  53  as a result of or during the relative movement. 
     In the embodiments according to  FIGS.  35  to  42    the securing device  52  is realized as a distinct part separately from the connecting arrangements  3 A,  3 A′,  3 B,  3 B′ and/or containers B 1 , B 2 . Hereby, the securing device  52  can be arranged between the connecting arrangement  3 A,  3 A′,  3 B,  3 B′ or the containers B 1 , B 4  during assembly if required. 
     Alternatively, or additionally, it is possible that securing arrangement  52  is formed by the container B 1 , B 4  and/or by the connecting arrangement  3 A,  3 A′,  3 B,  3 B′ or is connected to it in a fixed and/or permanent manner. 
     In this case, the receptacle  53  and the securing device  52 , in particular the one or more blocking members  54 , are provided at different containers B 1 , B 4  or connecting arrangements  3 A,  3 A′,  3 B,  3 B′, preferably opposing one another. By this measure the securing device  52  and/or the one or more blocking elements  54  can be shifted into the receptacle  53  during or after activation of the securing device  52 . 
     The securing device  52 , in particular the one or more blocking members  54 , can be connected to the container B 1 , B 4  or the connecting arrangement  3 A,  3 A′,  3 B,  3 B′ by positive locking, frictional connection and/or bonding or can be formed integrally herewith. Particularly preferably the securing device  52  and/or the blocking members  54  are fitted, injected and/or formed in a common production step with the container B 1 , B 4  or the connecting arrangement  3 A,  3 A′,  3 B,  3 B′, in particular by injection molding. However, it is possible that the securing device  52  is hold by snap fitting or by other measures at the container B 1 , B 4  or the connecting arrangement  3 A,  3 A′,  3 B,  3 B′. 
     The blocking members  54  preferably are held at the container B 1 , B 4  and/or the connecting arrangement  3 A,  3 A′,  3 B,  3 B′ in a film hinge like manner. Alternatively, or additionally, the blocking members  54  can be configured and/or fixed deformably. This lunables operation of the blocking members  54  also without a separately realized securing device  52 . Here, the blocking members  54  can be configured like depicted in  FIGS.  38  and/or  42    or differently. 
     In another aspect which may also be implemented independently, the invention relates to the use of the connecting arrangements and/or containers for mixing viscous liquids, particularly vaccines, preferably with a dynamic viscosity at 23° C. and a shear rate of 1 s −1  (particularly measured in the Brookfield viscometer RVT with spindle no. 4) of more than 1.5 or 2 Pa·s, preferably more than 4 Pa·s, particularly more than 6 Pa·s or 10 Pa·s, and/or less than 100 Pa·s, particularly less than 70 Pa·s, preferably less than 50 Pa·s, and/or in the range from 1 Pa·s to 100 Pa·s, particularly from 2 Pa·s to 70 Pa·s, preferably from 5 Pa·s to 50 Pa·s. The viscosities specified above within the scope of the present invention may be determined in particular by the method according to EN ISO 2884-1:2006. Viscous liquids in particular benefit from the large hydraulic minimum cross-section of the connection compared with the known solutions. 
     The aspects of the present invention can be combined with one another. In particular, aspects of the embodiments from  FIGS.  1  to  20    may also be used accordingly in the embodiment according to  FIGS.  21  to  37    and vice versa. 
     For example, the aspects relating to the sealing arrangement  39  and/or the support portion  46 A,  46 B may also be present in the cover device  6  from the embodiments in  FIGS.  1  to  20   . The cover devices  6 ,  25  may make it possible to obtain an, in particular, repeated or multi-stage sterile and/or sterilizable closure, while the aspects explained in connection with  FIG.  17    can be combined with the aspects concerning the sealing arrangement  39 , which were described in connection with  FIGS.  22  to  34   . Alternatively or additionally, the aspects relating to the deformation-based opening as explained in connection with  FIGS.  6  to  15    can be combined with aspects relating to the closure device  33  or vice versa. These examples make it clear that there are numerous preferred combinations of aspects which may form the subject of the present invention even if the combination is not expressly described.