Patent Publication Number: US-10316017-B2

Title: COT modulators and methods of use thereof

Description:
CROSS REFERENCE TO RELATED APPLICATIONS 
     This application is a divisional application of U.S. patent application Ser. No. 15/199,779, filed on Jun. 30, 2016, which claims the benefit under 35 U.S.C. 119(e) to U.S. Provisional Application No. 62/189,155, filed Jul. 6, 2015, and U.S. Provisional Application No. 62/269,061, filed Dec. 17, 2015, where the contents of each is incorporated herein by reference in its entirety. 
    
    
     FIELD 
     The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof. 
     BACKGROUND 
     Cot (cancer Osaka thyroid) protein is a serine/threonine kinase that is a member of the MAP kinase kinase kinase (MAP3K) family. It is also known as “Tpl2” (tumor progression locus), “MAP3K8” (mitogen-activated protein kinase kinase kinase 8) or “EST” (Ewing sarcoma transformant). Cot was identified by its oncogenic transforming activity in cells and has been shown to regulate oncogenic and inflammatory pathways. 
     Cot is known to be upstream in the MEK-ERK pathway and is essential for LPS induced tumor necrosis factor-α (TNF-α) production. Cot has been shown to be involved in both production and signaling of TNFα. TNFα is a pro-inflammatory cytokine and plays an important role in inflammatory diseases, such as rheumatoid arthritis (RA), multiple sclerosis (MS), inflammatory bowel disease (IBD), diabetes, sepsis, psoriasis, misregulated TNFα expression and graft rejection. 
     In some embodiments, the disease or condition treated by the administration of a compound of composition described herein includes acute gout and ankylosing spondylitis, allergic disorders, Alzheimer&#39;s disease, Amyotrophic lateral sclerosis (ALS), Amyotrophic lateral sclerosis and multiple sclerosis, atherosclerosis, bacterial infections, bone cancer pain and pain due to endometriosis, BRAF resistant melanoma, brain stem glioma or pituitary adenomas, burns, bursitis, cancer of the anal region, cancer of the endocrine system, cancer of the kidney or ureter (e.g. renal cell carcinoma carcinoma of the renal pelvis), cancer of the penis, cancer of the small intestine, cancer of the thyroid, cancer of the urethra, cancers of the blood such as acute myeloid leukemia, cancers of the tongue, carcinoma of the cervix, carcinoma of the endometrium, carcinoma of the fallopian tubes, carcinoma of the renal pelvis, carcinoma of the vagina or carcinoma of the vulva, chronic mueloid leukemia, chronic or acute leukemia, chronic pain, classic Bartter syndrome, common cold conjunctivitis, coronary heart disease, cutaneous or intraocular melanoma, dermatitis, dysmenorrhea, eczema, endometriosis, familial adenomatous polyposis, fibromyalgia, fungal infections, gout, gynecologic tumors, uterine sarcomas, carcinoma of the fallopian tubes, headache, hemophilic arthropathy, Parkinson&#39;s disease, AIDS, herpes zoster, Hodgkin&#39;s disease, Huntington&#39;s, hyperprostaglandin E syndrome, influenza, iritis, juvenile arthritis, juvenile onset rheumatoid arthritis, juvenile rheumatoid arthritis, low back and neck pain, lymphocytic lymphomas, myofascial disorders, myositis, neuralgia, neurodegenerative disorders such as Alzheimer&#39;s disease, neuroinflammatory disorders, neuropathic pain, carcinoma of the vulva, Parkinson&#39;s disease, pediatric malignancy, pulmonary fibrosis rectal cancer, rhinitis, sarcoidosis, sarcomas of soft tissues, scleritis, skin cancer, solid tumors of childhood, spinal axis tumors, sprains and strains, stomach cancer, stroke, subacute and chronic musculoskeletal pain syndromes such as bursitis, surgical or dental procedures, symptoms associated with influenza or other viral infections, synovitis, toothache, ulcers, uterine cancer, uterine sarcomas, uveitis, vasculitis, viral infections, viral infections {e.g. influenza) and wound healing. 
     Agents and methods that modulate the expression or activity of Cot, therefore, may be useful for preventing or treating such diseases. 
     SUMMARY 
     The present disclosure provides compounds that modulate the expression or activity of Cot. The disclosure also provides compositions, including pharmaceutical compositions, kits that include the compounds, and methods of using (or administering) and making the compounds. The compounds provided herein are useful in treating diseases, disorders, or conditions that are mediated by Cot. The disclosure also provides compounds for use in therapy. The disclosure further provides compounds for use in a method of treating a disease, disorder, or condition that is mediated by Cot. Moreover, the disclosure provides uses of the compounds in the manufacture of a medicament for the treatment of a disease, disorder or condition that is mediated by (or meadiated, at least in part, by) Cot. 
     In one aspect, provided is a compound having the structure of Formula I: 
                         
wherein
 
R 1  is hydrogen, —O—R 7 , —N(R 8 )(R 9 ), —C(O)—R 7 , —S(O) 2 —R 7 , —C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl;
         wherein each C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, heterocyclyl, aryl, and heteroaryl may be optionally substituted with one to four Z 1 ;
 
R 2  is hydrogen, —C(O)—R 7 , —C(O)O—R 7 , —C(O)N(R 7 ) 2 , C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl;
   wherein each C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl may be optionally substituted with one to four Z 2 ;
 
or R 1  and R 2  together with the nitrogen to which they are attached to form a heterocyclyl or heteroaryl, wherein each heterocyclyl or heteroaryl is optionally substituted with one to four Z 2 ;
 
R 3  is heterocyclyl or heteroaryl, wherein each heterocyclyl or heteroaryl is optionally substituted with one to four Z 3 ;
 
R 4  is aryl, wherein said aryl is optionally substituted with one to four Z 4 ;
 
R 5  is hydrogen, halo, —CN, —NO 2 , —O—R 7 , —N(R 8 )(R 9 ), —S(O)—R 7 , —S(O) 2 R 7 , —S(O) 2 N(R 7 ) 2 , —C(O)R 7 , —OC(O)—R 7 , —C(O)O—R 7 , —OC(O)O—R 7 , —OC(O)N(R 10 )(R 11 ), —C(O)N(R 7 ) 2 , —N(R 7 )C(O)(R 7 ), C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-9  alkylthio, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl;
   wherein each C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-9  alkylthio, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl may be optionally substituted with one to four Z 5 ;
 
R 6  is hydrogen, —C(O)—R 7 , —C(O)O—R 7 , —C(O)N(R 7 ) 2 , C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl;
   wherein each C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl may be optionally substituted with one to four Z 6 ;
 
each R 7  is independently hydrogen, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl;
   wherein each C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl may be optionally substituted with one to four Z 7 ;
 
R 8  and R 9  at each occurrence are independently hydrogen, —S(O) 2 R 10 , —C(O)—R 10 , —C(O)O—R 10 , —C(O)N(R 10 )(R 11 ), C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl;
   wherein each C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl may be optionally substituted with one to four Z 8 ;
 
R 10  and R 11  at each occurrence are independently hydrogen, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl,
   wherein each C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl optionally is substituted with one to four Z 1b ;
 
each Z 1 , Z 2 , Z 3 , Z 4 , Z 5 , Z 6 , Z 7  and Z 8  is independently hydrogen, oxo, halo, —NO 2 , —N 3 , —CN, thioxo, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, —O—R 12 , —C(O)—R 12 , —C(O)O—R 12 , —C(O)—N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —N(R 12 )C(O)—R 12 , —N(R 12 )C(O)O—R 12 , —N(R 12 )C(O)N(R 13 )(R 14 ), —N(R 12 )S(O) 2 (R 12 ), —NR 12 S(O) 2 N(R 13 )(R 14 ), —NR 12 S(O) 2 O(R 12 ), —OC(O)R 12 , —OC(O)—N(R 13 )(R 14 ), —P(O)(OR 12 ) 2 , —OP(O)(OR 12 ) 2 , —CH 2 P(O)(OR 12 ) 2 , —OCH 2 P(O)(OR 12 ) 2 , —C(O)OCH 2 P(O)(OR 12 ) 2 , —P(O)(R 12 )(OR 12 ), —OP(O)(R 12 )(OR 12 ), —CH 2 P(O)(R 12 )(OR 12 ) OCH 2 P(O)(R 12 )(OR 12 ), —C(O)OCH 2 P(O)(R 12 )(OR 12 ), —P(O)(N(R 12 ) 2 ) 2 , —OP(O)(N(R 12 ) 2 ) 2 , —CH 2 P(O)(N(R 12 ) 2 ) 2 , —OCH 2 P(O)(N(R 12 ) 2 ) 2 , —C(O)OCH 2 P(O)(N(R 12 ) 2 ) 2 —P(O)(N(R 12 ) 2 )(OR 12 ), —OP(O)(N(R 12 ) 2 )(OR 12 ), —CH 2 P(O)(N(R 12 ) 2 )(OR 12 ), —OCH 2 P(O)(N(R 12 ) 2 )(OR 12 ), —C(O)OCH 2 P(O)(N(R 12 ) 2 )(OR 12 ), —P(O)(R 12 )(N(R 12 ) 2 ), —OP(O)(R 12 )(N(R 12 ) 2 ), —CH 2 P(O)(R 12 )(N(R 12 ) 2 ), —OCH 2 P(O)(R 12 )(N(R 12 ) 2 ), —C(O)OCH 2 P(O)(R 12 )(N(R 12 ) 2 ), —Si(R 12 ) 3 , —S—R 12 , —S(O)R 12 , —S(O)(NH)R 12 , —S(O) 2 R 12  or —S(O) 2 N(R 13 )(R 14 );
   wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1a  groups;
 
each Z 1a  is independently oxo, halo, thioxo, —NO 2 , —CN, —N 3 , C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, —O—R 12 , —C(O)R 12 , —C(O)O—R 12 , —C(O)N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —N(R 12 )—C(O)R 12 , —N(R 12 )C(O)O(R 12 ), —N(R 12 )C(O)N(R 13 )(R 14 ), —N(R 12 )S(O) 2 (R 12 ), —N(R 12 )S(O) 2 —N(R 13 )(R 14 ), —N(R 12 )S(O) 2 O(R 12 ), —OC(O)R 12 , —OC(O)OR 12 , —OC(O)—N(R 13 )(R 14 ), —Si(R 12 ) 3 , —S—R 12 , —S(O)R 12 , —S(O)(NH)R 12 , —S(O) 2 R 12  or —S(O) 2 N(R 13 )(R 14 );
   wherein any alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1b  groups;
 
each R 12  is independently hydrogen, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, aryl, heteroaryl or heterocyclyl,
   wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1b  groups;
 
R 13  and R 14  at each occurrence are each independently hydrogen, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, aryl, heteroaryl or heterocyclyl;
   wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1b  groups, or R 13  and R 14  together with the nitrogen to which they are attached form a heterocyclyl, wherein said heterocyclyl is optionally substituted with one to four Z 1b  groups;
 
each R 15  is independently halo, —CN, —NO 2 , —O—R 7 , —N(R 8 )(R 9 ), —S(O)—R 7 , —S(O) 2 R 7 , —S(O) 2 N(R 7 ) 2 , —C(O)R 7 , —OC(O)—R 7 , —C(O)O—R 7 , —OC(O)O—R 7 , —OC(O)N(R 10 )(R 11 ), —C(O)N(R 7 ) 2 , —N(R 7 )C(O)(R 7 ), C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-9  alkylthio, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl; and
 
each Z 1b  is independently oxo, thioxo, hydroxy, halo, —NO 2 , —N 3 , —CN, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, —O(C 1-9  alkyl), —O(C 2-6  alkenyl), —O(C 2-6  alkynyl), —O(C 3-15  cycloalkyl), —O(C 1-8  haloalkyl), —O(aryl), —O(heteroaryl), —O(heterocyclyl), —NH 2 , —NH(C 1-9  alkyl), —NH(C 2-6  alkenyl), —NH(C 2-6  alkynyl), —NH(C 3-15  cycloalkyl), —NH(C 1-8  haloalkyl), —NH(aryl), —NH(heteroaryl), —NH(heterocyclyl), —N(C 1-9  alkyl) 2 , —N(C 3-15  cycloalkyl) 2 , —N(C 2-6  alkenyl) 2 , —N(C 2-6  alkynyl) 2 , —N(C 3-15  cycloalkyl) 2 , —N(C 1-8  haloalkyl) 2 , —N(aryl) 2 , —N(heteroaryl) 2 , —N(heterocyclyl) 2 , —N(C 1-9  alkyl)(C 3-15  cycloalkyl), —N(C 1-9  alkyl)(C 2-6  alkenyl), —N(C 1-9  alkyl)(C 2-6  alkynyl), —N(C 1-9  alkyl)(C 3-15  cycloalkyl), —N(C 1-9  alkyl)(C 1-8  haloalkyl), —N(C 1-9  alkyl)(aryl), —N(C 1-9  alkyl)(heteroaryl), —N(C 1-9  alkyl)(heterocyclyl), —C(O)(C 1-9  alkyl), —C(O)(C 2-6  alkenyl), —C(O)(C 2-6  alkynyl), —C(O)(C 3-15  cycloalkyl), —C(O)(C 1-8  haloalkyl), —C(O)(aryl), —C(O)(heteroaryl), —C(O)(heterocyclyl), —C(O)O(C 1-9  alkyl), —C(O)O(C 2-6  alkenyl), —C(O)O(C 2-6  alkynyl), —C(O)O(C 3-15  cycloalkyl), —C(O)O(C 1-8  haloalkyl), —C(O)O(aryl), —C(O)O(heteroaryl), —C(O)O(heterocyclyl), —C(O)NH 2 , —C(O)NH(C 1-9  alkyl), —C(O)NH(C 2-6  alkenyl), —C(O)NH(C 2-6  alkynyl), —C(O)NH(C 3-15  cycloalkyl), —C(O)NH(C 1-8  haloalkyl), —C(O)NH(aryl), —C(O)NH(heteroaryl), —C(O)NH(heterocyclyl), —C(O)N(C 1-9  alkyl) 2 , —C(O)N(C 3-15  cycloalkyl) 2 , —C(O)N(C 2-6  alkenyl) 2 , —C(O)N(C 2-6  alkynyl) 2 , —C(O)N(C 3-15  cycloalkyl) 2 , —C(O)N(C 1-8  haloalkyl) 2 , —C(O)N(aryl) 2 , —C(O)N(heteroaryl) 2 , —C(O)N(heterocyclyl) 2 , —NHC(O)(C 1-9  alkyl), —NHC(O)(C 2-6  alkenyl), —NHC(O)(C 2-6  alkynyl), —NHC(O)(C 3-15  cycloalkyl), —NHC(O)(C 1-8  haloalkyl), —NHC(O)(aryl), —NHC(O)(heteroaryl), —NHC(O)(heterocyclyl), —NHC(O)O(C 1-9  alkyl), —NHC(O)O(C 2-6  alkenyl), —NHC(O)O(C 2-6  alkynyl), —NHC(O)O(C 3-15  cycloalkyl), —NHC(O)O(C 1-8  haloalkyl), —NHC(O)O(aryl), —NHC(O)O(heteroaryl), —NHC(O)O(heterocyclyl), —NHC(O)NH(C 1-9  alkyl), —NHC(O)NH(C 2-6  alkenyl), —NHC(O)NH(C 2-6  alkynyl), —NHC(O)NH(C 3-15  cycloalkyl), —NHC(O)NH(C 1-8  haloalkyl), —NHC(O)NH(aryl), —NHC(O)NH(heteroaryl), —NHC(O)NH(heterocyclyl), —SH, —S(C 1-9  alkyl), —S(C 2-6  alkenyl), —S(C 2-6  alkynyl), —S(C 3-15  cycloalkyl), —S(C 1-8  haloalkyl), —S(aryl), —S(heteroaryl), —S(heterocyclyl), —NHS(O)(C 1-9  alkyl), —N(C 1-9  alkyl)(S(O)(C 1-9  alkyl), —S(O)N(C 1-9  alkyl) 2 , —S(O)(C 1-9  alkyl), —S(O)(NH)(C 1-9  alkyl), —S(O)(C 2-6  alkenyl), —S(O)(C 2-6  alkynyl), —S(O)(C 3-15  cycloalkyl), —S(O)(C 1-8  haloalkyl), —S(O)(aryl), —S(O)(heteroaryl), —S(O)(heterocyclyl), —S(O) 2 (C 1-9  alkyl), —S(O) 2 (C 2-6  alkenyl), —S(O) 2 (C 2-6  alkynyl), —S(O) 2 (C 3-15  cycloalkyl), —S(O) 2 (C 1-8  haloalkyl), —S(O) 2 (aryl), —S(O) 2 (heteroaryl), —S(O) 2 (heterocyclyl), —S(O) 2 NH(C 1-9  alkyl), or —S(O) 2 N(C 1-9  alkyl) 2 ;
   wherein any alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with one to four halo, C 1-9  alkyl, C 1-8  haloalkyl, —OH, —NH 2 , —NH(C 1-9  alkyl), —NH(C 3-15  cycloalkyl), —NH(C 1-8  haloalkyl), —NH(aryl), —NH(heteroaryl), —NH(heterocyclyl), —N(C 1-9  alkyl) 2 , —N(C 3-15  cycloalkyl) 2 , —NHC(O)(C 3-15  cycloalkyl), —NHC(O)(C 1-8  haloalkyl), —NHC(O)(aryl), —NHC(O)(heteroaryl), —NHC(O)(heterocyclyl), —NHC(O)O(C 1-9  alkyl), —NHC(O)O(C 2-6  alkynyl), —NHC(O)O(C 3-15  cycloalkyl), —NHC(O)O(C 1-8  haloalkyl), —NHC(O)O(aryl), —NHC(O)O(heteroaryl), —NHC(O)O(heterocyclyl), —NHC(O)NH(C 1-9  alkyl), —S(O)(NH)(C 1-9  alkyl), —S(O) 2 (C 1-9  alkyl), —S(O) 2 (C 3-15  cycloalkyl), —S(O) 2 (C 1-8  haloalkyl), —S(O) 2 (aryl), —S(O) 2 (heteroaryl), —S(O) 2 (heterocyclyl), —S(O) 2 NH(C 1-9  alkyl), —S(O) 2 N(C 1-9  alkyl) 2 , —O(C 3-15  cycloalkyl), —O(C 1-8  haloalkyl), —O(aryl), —O(heteroaryl), —O(heterocyclyl), or —O(C 1-9  alkyl);
 
m is 0, 1, or 2;
 
or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof.
       

     Some embodiments provide a method of using (or administering) the compounds of Formula I, or additional Formula(s) described throughout, in the treatment of a disease or condition in a mammal, particularly a human, that is amenable to treatment by an Cot modulator. 
     In certain embodiments, the disclosure provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of the disclosure (e.g. a compound of Formula I or additional Formulas described throughout), and at least one pharmaceutically acceptable excipient. 
    
    
     DETAILED DESCRIPTION 
     Definitions and General Parameters 
     The following description sets forth exemplary methods, parameters and the like. It should be recognized, however, that such description is not intended as a limitation on the scope of the present disclosure but is instead provided as a description of exemplary embodiments. 
     As used in the present specification, the following words, phrases and symbols are generally intended to have the meanings as set forth below, except to the extent that the context in which they are used indicates otherwise. 
     A dash (“-”) that is not between two letters or symbols is used to indicate a point of attachment for a substituent. For example, —C(O)NH 2  is attached through the carbon atom. A dash at the front or end of a chemical group is a matter of convenience; chemical groups may be depicted with or without one or more dashes without losing their ordinary meaning. A wavy line drawn through a line in a structure indicates a point of attachment of a group. Unless chemically or structurally required, no directionality is indicated or implied by the order in which a chemical group is written or named. 
     The prefix “C u-v ” indicates that the following group has from u to v carbon atoms. For example, “C 1-6  alkyl” indicates that the alkyl group has from 1 to 6 carbon atoms. 
     Reference to “about” a value or parameter herein includes (and describes) embodiments that are directed to that value or parameter per se. In certain embodiments, the term “about” includes the indicated amount ±10%. In other embodiments, the term “about” includes the indicated amount ±5%. In certain other embodiments, the term “about” includes the indicated amount ±1%. Also, to the term “about X” includes description of “X”. Also, the singular forms “a” and “the” include plural references unless the context clearly dictates otherwise. Thus, e.g., reference to “the compound” includes a plurality of such compounds and reference to “the assay” includes reference to one or more assays and equivalents thereof known to those skilled in the art. 
     “Alkyl” refers to an unbranched or branched saturated hydrocarbon chain. As used herein, alkyl has 1 to 20 carbon atoms (i.e., C 1-20  alkyl), 1 to 8 carbon atoms (i.e., C 1-8  alkyl), 1 to 6 carbon atoms (i.e., C 1-6  alkyl), or 1 to 4 carbon atoms (i.e., C 1-4  alkyl). Examples of alkyl groups include methyl, ethyl, propyl, isopropyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, pentyl, 2-pentyl, isopentyl, neopentyl, hexyl, 2-hexyl, 3-hexyl, and 3-methylpentyl. When an alkyl residue having a specific number of carbons is named by chemical name or identified by molecular formula, all positional isomers having that number of carbons may be encompassed; thus, for example, “butyl” includes n-butyl (i.e. —((CH 2 ) 3 CH 3 ), sec-butyl (i.e. —CH(CH 3 )CH 2 CH 3 ), isobutyl (i.e. —CH 2 CH(CH 3 ) 2 ) and tert-butyl (i.e. —C(CH 3 ) 3 ); and “propyl” includes n-propyl (i.e. —(CH 2 ) 2 CH 3 ) and isopropyl (i.e. —CH(CH 3 ) 2 ). 
     “Alkenyl” refers to an alkyl group containing at least one carbon-carbon double bond and having from 2 to 20 carbon atoms (i.e., C 2-20  alkenyl), 2 to 8 carbon atoms (i.e., C 2-8  alkenyl), 2 to 6 carbon atoms (i.e., C 2-6  alkenyl), or 2 to 4 carbon atoms (i.e., C 2-4  alkenyl). Examples of alkenyl groups include ethenyl, propenyl, butadienyl (including 1,2-butadienyl and 1,3-butadienyl). 
     “Alkynyl” refers to an alkyl group containing at least one carbon-carbon triple bond and having from 2 to 20 carbon atoms (i.e., C 2-20  alkynyl), 2 to 8 carbon atoms (i.e., C 2-8  alkynyl), 2 to 6 carbon atoms (i.e., C 2-6  alkynyl), or 2 to 4 carbon atoms (i.e., C 2-4  alkynyl). The term “alkynyl” also includes those groups having one triple bond and one double bond. 
     “Alkoxy” refers to the group “alkyl-O—”. Examples of alkoxy groups include methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, tert-butoxy, sec-butoxy, n-pentoxy, n-hexoxy, and 1,2-dimethylbutoxy. 
     “Haloalkoxy” refers to an alkoxy group as defined above, wherein one or more hydrogen atoms are replaced by a halogen. 
     “Alkylthio” refers to the group “alkyl-S—”. 
     “Acyl” refers to a group —C(O)R, wherein R is hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroalkyl, or heteroaryl; each of which may be optionally substituted, as defined herein. Examples of acyl include formyl, acetyl, cyclohexylcarbonyl, cyclohexylmethyl-carbonyl, and benzoyl. 
     “Amido” refers to both a “C-amido” group which refers to the group —C(O)NR y R z  and an “N-amido” group which refers to the group —NR y C(O)R z , wherein R y  and R z  are independently selected from the group consisting of hydrogen, alkyl, aryl, haloalkyl, or heteroaryl; each of which may be optionally substituted. 
     “Amino” refers to the group —NR y R z  wherein R y  and R z  are independently selected from the group consisting of hydrogen, alkyl, haloalkyl, aryl, or heteroaryl; each of which may be optionally substituted. 
     “Amidino” refers to —C(NH)(NH 2 ). 
     “Aryl” refers to an aromatic carbocyclic group having a single ring (e.g. monocyclic) or multiple rings (e.g. bicyclic or tricyclic) including fused systems. As used herein, aryl has 6 to 20 ring carbon atoms (i.e., C 6-20  aryl), 6 to 12 carbon ring atoms (i.e., C 6-12  aryl), or 6 to 10 carbon ring atoms (i.e., C 6-10  aryl). Examples of aryl groups include phenyl, naphthyl, fluorenyl, and anthryl. Aryl, however, does not encompass or overlap in any way with heteroaryl defined below. If one or more aryl groups are fused with a heteroaryl, the resulting ring system is heteroaryl. If one or more aryl groups are fused with a heterocyclyl the resulting ring system is heterocyclyl. 
     “Azido” refers to —N 3 . 
     “Carbamoyl” refers to both an “O-carbamoyl” group which refers to the group —O—C(O)NR y R z  and an “N-carbamoyl” group which refers to the group —NR y C(O)OR z , wherein R y  and R z  are independently selected from the group consisting of hydrogen, alkyl, aryl, haloalkyl, or heteroaryl; each of which may be optionally substituted. 
     “Carboxyl” refers to —C(O)OH. 
     “Carboxyl ester” refers to both —OC(O)R and —C(O)OR, wherein R is hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroalkyl, or heteroaryl; each of which may be optionally substituted, as defined herein. 
     “Cyano” or “carbonitrile” refers to the group —CN. 
     “Cycloalkyl” refers to a saturated or partially unsaturated cyclic alkyl group having a single ring or multiple rings including fused, bridged, and spiro ring systems. The term “cycloalkyl” includes cycloalkenyl groups (i.e. the cyclic group having at least one double bond). As used herein, cycloalkyl has from 3 to 20 ring carbon atoms (i.e., C 3-20  cycloalkyl), 3 to 12 ring carbon atoms (i.e., C 3-12  cycloalkyl), 3 to 10 ring carbon atoms (i.e., C 3-10  cycloalkyl), 3 to 8 ring carbon atoms (i.e., C 3-8  cycloalkyl), or 3 to 6 ring carbon atoms (i.e., C 3-6  cycloalkyl). Examples of cycloalkyl groups include cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl. 
     “Guanidino” refers to —NHC(NH)(NH 2 ). 
     “Hydrazino” refers to —NHNH 2 . 
     “Imino” refers to a group —C(NR)R, wherein each R is alkyl, cycloalkyl, heterocyclyl, aryl, heteroalkyl, or heteroaryl; each of which may be optionally substituted, as defined herein. 
     “Halogen” or “halo” includes fluoro, chloro, bromo, and iodo. 
     “Haloalkyl” refers to an unbranched or branched alkyl group as defined above, wherein one or more hydrogen atoms are replaced by a halogen. For example, where a residue is substituted with more than one halogen, it may be referred to by using a prefix corresponding to the number of halogen moieties attached. Dihaloalkyl and trihaloalkyl refer to alkyl substituted with two (“di”) or three (“tri”) halo groups, which may be, but are not necessarily, the same halogen. Examples of haloalkyl include difluoromethyl (—CHF 2 ) and trifluoromethyl (—CF 3 ). 
     “Heteroalkyl” refers to an alkyl group in which one or more of the carbon atoms (and any associated hydrogen atoms) are each independently replaced with the same or different heteroatomic group. The term “heteroalkyl” includes unbranched or branched saturated chain having carbon and heteroatoms. By way of example, 1, 2 or 3 carbon atoms may be independently replaced with the same or different heteroatomic group. Heteroatomic groups include, but are not limited to, —NR—, —O—, —S—, —S(O)—, —S(O) 2 —, and the like, where R is H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted. Examples of heteroalkyl groups include —OCH 3 , —CH 2 OCH 3 , —SCH 3 , —CH 2 SCH 3 , —NRCH 3 , and —CH 2 NRCH 3 , where R is hydrogen, alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl, each of which may be optionally substituted. As used herein, heteroalkyl include 1 to 10 carbon atoms, 1 to 8 carbon atoms, or 1 to 4 carbon atoms; and 1 to 3 heteroatoms, 1 to 2 heteroatoms, or 1 heteroatom. 
     “Heteroaryl” refers to an aromatic group having a single ring, multiple rings, or multiple fused rings, with one or more ring heteroatoms independently selected from nitrogen, oxygen, and sulfur. As used herein, heteroaryl includes 1 to 20 ring carbon atoms (i.e., C 1-20  heteroaryl), 3 to 12 ring carbon atoms (i.e., C 3-12  heteroaryl), or 3 to 8 carbon ring atoms (i.e., C 3-8  heteroaryl); and 1 to 5 heteroatoms, 1 to 4 heteroatoms, 1 to 3 ring heteroatoms, 1 to 2 ring heteroatoms, or L ring heteroatom independently selected from nitrogen, oxygen, and sulfur. Examples of heteroaryl groups include pyrimidinyl, purinyl, pyridyl, pyridazinyl, benzothiazolyl, and pyrazolyl. Examples of the fused-heteroaryl rings include, but are not limited to, benzo[d]thiazolyl, quinolinyl, isoquinolinyl, benzo[b]thiophenyl, indazolyl, benzo[d]imidazolyl, pyrazolo[1,5-a]pyridinyl, and imidazo[1,5-a]pyridinyl, where the heteroaryl can be bound via either ring of the fused system. Any aromatic ring, having a single or multiple fused rings, containing at least one heteroatom, is considered a heteroaryl regardless of the attachment to the remainder of the molecule (i.e., through any one of the fused rings). Heteroaryl does not encompass or overlap with aryl as defined above. 
     “Heterocyclyl” refers to a saturated or unsaturated cyclic alkyl group, with one or more ring heteroatoms independently selected from nitrogen, oxygen and sulfur. The term “heterocyclyl” includes heterocycloalkenyl groups (i.e. the heterocyclyl group having at least one double bond), bridged-heterocyclyl groups, fused-heterocyclyl groups, and spiro-heterocyclyl groups. A heterocyclyl may be a single ring or multiple rings wherein the multiple rings may be fused, bridged, or spiro. Any non-aromatic ring containing at least one heteroatom is considered a heterocyclyl, regardless of the attachment (i.e., can be bound through a carbon atom or a heteroatom). Further, the term heterocyclyl is intended to encompass any non-aromatic ring containing at least one heteroatom, which ring may be fused to an aryl or heteroaryl ring, regardless of the attachment to the remainder of the molecule. As used herein, heterocyclyl has 2 to 20 ring carbon atoms (i.e., C 2-20  heterocyclyl), 2 to 12 ring carbon atoms (i.e., C 2-12  heterocyclyl), 2 to 10 ring carbon atoms (i.e., C 2-10  heterocyclyl), 2 to 8 ring carbon atoms (i.e., C 2-8  heterocyclyl), 3 to 12 ring carbon atoms (i.e., C 3-12  heterocyclyl), 3 to 8 ring carbon atoms (i.e., C 3-8  heterocyclyl), or 3 to 6 ring carbon atoms (i.e., C 3-6  heterocyclyl); having 1 to 5 ring heteroatoms, 1 to 4 ring heteroatoms, 1 to 3 ring heteroatoms, 1 to 2 ring heteroatoms, or 1 ring heteroatom independently selected from nitrogen, sulfur or oxygen. Examples of heterocyclyl groups include pyrrolidinyl, piperidinyl, piperazinyl, oxetanyl, dioxolanyl, azetidinyl, and morpholinyl. As used herein, the term “bridged-heterocyclyl” refers to a four- to ten-membered cyclic moiety connected at two non-adjacent atoms of the heterocyclyl with one or more (e.g. 1 or 2) four- to ten-membered cyclic moiety having at least one heteroatom where each heteroatom is independently selected from nitrogen, oxygen, and sulfur. As used herein, bridged-heterocyclyl includes bicyclic and tricyclic ring systems. Also used herein, the term “spiro-heterocyclyl” refers to a ring system in which a three- to ten-membered heterocyclyl has one or more additional ring, wherein the one or more additional ring is three- to ten-membered cycloalkyl or three- to ten-membered heterocyclyl, where a single atom of the one or more additional ring is also an atom of the three- to ten-membered heterocyclyl. Examples of the spiro-heterocyclyl rings include bicyclic and tricyclic ring systems, such as 2-oxa-7-azaspiro[3.5]nonanyl, 2-oxa-6-azaspiro[3.4]octanyl, and 6-oxa-1-azaspiro[3.3]heptanyl. Examples of the fused-heterocyclyl rings include, but are not limited to, 1,2,3,4-tetrahydroisoquinolinyl, 4,5,6,7-tetrahydrothieno[2,3-c]pyridinyl, indolinyl, and isoindolinyl, where the heterocyclyl can be bound via either ring of the fused system. 
     “Hydroxy” or “hydroxyl” refers to the group —OH. 
     “Oxo” refers to the group (═O) or (O). 
     “Nitro” refers to the group —NO 2 . 
     “Sulfonyl” refers to the group —S(O) 2 R, where R is alkyl, haloalkyl, heterocyclyl, cycloalkyl, heteroaryl, or aryl. Examples of sulfonyl are methylsulfonyl, ethylsulfonyl, phenylsulfonyl, and toluenesulfonyl. “Alkylsulfonyl” refers to the group —S(O) 2 R, where R is alkyl. 
     “Alkylsulfinyl” refers to the group —S(O)R, where R is alkyl. 
     “Thiocyanate”—SCN. 
     “Thiol” refers to the group —SR, where R is alkyl, haloalkyl, heterocyclyl, cycloalkyl, heteroaryl, or aryl. 
     “Thioxo” or “thione” refer to the group (═S) or (S). 
     Certain commonly used alternative chemical names may be used. For example, a divalent group such as a divalent “alkyl” group, a divalent “aryl” group, etc., may also be referred to as an “alkylene” group or an “alkylenyl” group, an “arylene” group or an “arylenyl” group, respectively. Also, unless indicated explicitly otherwise, where combinations of groups are referred to herein as one moiety, e.g. arylalkyl, the last mentioned group contains the atom by which the moiety is attached to the rest of the molecule. 
     The terms “optional” or “optionally” means that the subsequently described event or circumstance may or may not occur, and that the description includes instances where said event or circumstance occurs and instances in which it does not. Also, the term “optionally substituted” refers to any one or more hydrogen atoms on the designated atom or group may or may not be replaced by a moiety other than hydrogen. 
     Some of the compounds exist as tautomers. Tautomers isomers are in equilibrium with one another. For example, amide containing compounds may exist in equilibrium with imidic acid tautomers. Regardless of which tautomer is shown, and regardless of the nature of the equilibrium among tautomers, the compounds are understood by one of ordinary skill in the art to comprise both amide and imidic acid tautomers. Thus, the amide containing compounds are understood to include their imidic acid tautomers. Likewise, the imidic acid containing compounds are understood to include their amide tautomers. 
     Any formula or structure given herein, is also intended to represent unlabeled forms as well as isotopically labeled forms of the compounds. Isotopically labeled compounds have structures depicted by the formulas given herein except that one or more atoms are replaced by an atom having a selected atomic mass or mass number. Examples of isotopes that can be incorporated into compounds of the disclosure include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorous, fluorine and chlorine, such as, but not limited to  2 H (deuterium, D),  3 H (tritium),  11 C,  13 C,  14 C,  15 N,  18 F,  31 P,  32 P,  35 S,  36 Cl and  125 I. Various isotopically labeled compounds of the present disclosure, for example those into which radioactive isotopes such as  3 H,  13 C and  14 C are incorporated. Such isotopically labelled compounds may be useful in metabolic studies, reaction kinetic studies, detection or imaging techniques, such as positron emission tomography (PET) or single-photon emission computed tomography (SPECT) including drug or substrate tissue distribution assays or in radioactive treatment of patients. 
     The disclosure also includes “deuterated analogues” of compounds of Formula I in which from 1 to n hydrogens attached to a carbon atom is/are replaced by deuterium, in which n is the number of hydrogens in the molecule. Such compounds exhibit increased resistance to metabolism and are thus useful for increasing the half-life of any compound of Formula I when administered to a mammal, particularly a human. See, for example, Foster, “Deuterium Isotope Effects in Studies of Drug Metabolism,” Trends Pharmacol. Sci. 5(12):524-527 (1984). Such compounds are synthesized by means well known in the art, for example by employing starting materials in which one or more hydrogens have been replaced by deuterium. 
     Deuterium labelled or substituted therapeutic compounds of the disclosure may have improved DMPK (drug metabolism and pharmacokinetics) properties, relating to distribution, metabolism and excretion (ADME). Substitution with heavier isotopes such as deuterium may afford certain therapeutic advantages resulting from greater metabolic stability, for example increased in vivo half-life, reduced dosage requirements and/or an improvement in therapeutic index. An  18 F labeled compound may be useful for PET or SPECT studies. Isotopically labeled compounds of this disclosure and prodrugs thereof can generally be prepared by carrying out the procedures disclosed in the schemes or in the examples and preparations described below by substituting a readily available isotopically labeled reagent for a non-isotopically labeled reagent. It is understood that deuterium in this context is regarded as a substituent in the compound of Formula I. 
     The concentration of such a heavier isotope, specifically deuterium, may be defined by an isotopic enrichment factor. In the compounds of this disclosure any atom not specifically designated as a particular isotope is meant to represent any stable isotope of that atom. Unless otherwise stated, when a position is designated specifically as “H” or “hydrogen”, the position is understood to have hydrogen at its natural abundance isotopic composition. Accordingly, in the compounds of this disclosure any atom specifically designated as a deuterium (D) is meant to represent deuterium. 
     In many cases, the compounds of this disclosure are capable of forming acid and/or base salts by virtue of the presence of amino and/or carboxyl groups or groups similar thereto. 
     Provided are also pharmaceutically acceptable salts, hydrates, solvates, tautomeric forms, polymorphs, and prodrugs of the compounds described herein. “Pharmaceutically acceptable” or “physiologically acceptable” refer to compounds, salts, compositions, dosage forms and other materials which are useful in preparing a pharmaceutical composition that is suitable for veterinary or human pharmaceutical use. 
     The term “pharmaceutically acceptable salt” of a given compound refers to salts that retain the biological effectiveness and properties of the given compound, and which are not biologically or otherwise undesirable. “Pharmaceutically acceptable salts” or “physiologically acceptable salts” include, for example, salts with inorganic acids and salts with an organic acid. In addition, if the compounds described herein are obtained as an acid addition salt, the free base can be obtained by basifying a solution of the acid salt. Conversely, if the product is a free base, an addition salt, particularly a pharmaceutically acceptable addition salt, may be produced by dissolving the free base in a suitable organic solvent and treating the solution with an acid, in accordance with conventional procedures for preparing acid addition salts from base compounds. Those skilled in the art will recognize various synthetic methodologies that may be used to prepare nontoxic pharmaceutically acceptable addition salts. Pharmaceutically acceptable acid addition salts may be prepared from inorganic and organic acids. Salts derived from inorganic acids include hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like. Salts derived from organic acids include acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, malic acid, malonic acid, succinic acid, maleic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluene-sulfonic acid, salicylic acid, and the like. Likewise, pharmaceutically acceptable base addition salts can be prepared from inorganic and organic bases. Salts derived from inorganic bases include, by way of example only, sodium, potassium, lithium, ammonium, calcium and magnesium salts. Salts derived from organic bases include, but are not limited to, salts of primary, secondary and tertiary amines, such as alkyl amines (i.e., NH 2 (alkyl)), dialkyl amines (i.e., HN(alkyl) 2 ), trialkyl amines (i.e., N(alkyl) 3 ), substituted alkyl amines (i.e., NH 2  (substituted alkyl)), di(substituted alkyl) amines (i.e., HN(substituted alkyl) 2 ), tri(substituted alkyl) amines (i.e., N(substituted alkyl) 3 ), alkenyl amines (i.e., NH 2  (alkenyl)), dialkenyl amines (i.e., HN(alkenyl) 2 ), trialkenyl amines (i.e., N(alkenyl) 3 ), substituted alkenyl amines (i.e., NH 2  (substituted alkenyl)), di(substituted alkenyl) amines (i.e., HN(substituted alkenyl) 2 ), tri(substituted alkenyl) amines (i.e., N(substituted alkenyl) 3 , mono-, di- or tri-cycloalkyl amines (i.e., NH 2 (cycloalkyl), HN(cycloalkyl) 2 , N(cycloalkyl) 3 ), mono-, di- or tri-arylamines (i.e., NH 2 (aryl), HN(aryl) 2 , N(aryl) 3 ), or mixed amines, etc. Specific examples of suitable amines include, by way of example only, isopropylamine, trimethyl amine, diethyl amine, tri(iso-propyl) amine, tri(n-propyl) amine, ethanolamine, 2-dimethylaminoethanol, piperazine, piperidine, morpholine, N-ethylpiperidine, and the like. 
     The term “substituted” means that any one or more hydrogen atoms on the designated atom or group is replaced with one or more substituents other than hydrogen, provided that the designated atom&#39;s normal valence is not exceeded. The one or more substituents include, but are not limited to, alkyl, alkenyl, alkynyl, alkoxy, acyl, amino, amido, amidino, aryl, azido, carbamoyl, carboxyl, carboxyl ester, cyano, guanidino, halo, haloalkyl, haloalkoxy, heteroalkyl, heteroaryl, heterocyclyl, hydroxy, hydrazino, imino, oxo, nitro, alkylsulfinyl, sulfonic acid, alkylsulfonyl, thiocyanate, thiol, thione, or combinations thereof. Polymers or similar indefinite structures arrived at by defining substituents with further substituents appended ad infinitum (e.g., a substituted aryl having a substituted alkyl which is itself substituted with a substituted aryl group, which is further substituted by a substituted heteroalkyl group, etc.) are not intended for inclusion herein. Unless otherwise noted, the maximum number of serial substitutions in compounds described herein is three. For example, serial substitutions of substituted aryl groups with two other substituted aryl groups are limited to ((substituted aryl)substituted aryl) substituted aryl. Similarly, the above definitions are not intended to include impermissible substitution patterns (e.g., methyl substituted with 5 fluorines or heteroaryl groups having two adjacent oxygen ring atoms). Such impermissible substitution patterns are well known to the skilled artisan. When used to modify a chemical group, the term “substituted” may describe other chemical groups defined herein. Unless specified otherwise, where a group is described as optionally substituted, any substituents of the group are themselves unsubstituted. For example, in some embodiments, the term “substituted alkyl” refers to an alkyl group having one or more substituents including hydroxyl, halo, alkoxy, cycloalkyl, heterocyclyl, aryl, and heteroaryl. In other embodiments, the one or more substituents may be further substituted with halo, alkyl, haloalkyl, hydroxyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl, each of which is substituted. In other embodiments, the substituents may be further substituted with halo, alkyl, haloalkyl, alkoxy, hydroxyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, each of which is unsubstituted. 
     As used herein, “pharmaceutically acceptable carrier” or “pharmaceutically acceptable excipient” includes any and all solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents and the like. The use of such media and agents for pharmaceutically active substances is well known in the art. Except insofar as any conventional media or agent is incompatible with the active ingredient, its use in the therapeutic compositions is contemplated. Supplementary active ingredients can also be incorporated into the compositions. 
     A “solvate” is formed by the interaction of a solvent and a compound. Solvates of salts of the compounds described herein are also provided. Hydrates of the compounds described herein are also provided. 
                            List of Abbreviations and Acronyms                     Abbreviation   Meaning               ° C.   Degree Celsius       Ac   Acetyl       aq.   Aqueous       ATP   Adenosine triphosphate       BOC   tert-Butoxycarbonyl       br   Broad       BSA   Bovine serum albumin       Cbz   Carboxybenzyl       COD   Cyclooctadiene       COPD   Chronic obstructive pulmonary disease       Cot   Cancer Osaka Thyroid       Cp   Cyclopentadienyl       d   Doublet       DABCO   1,4-Diazabicyclo[2.2.2]octane       DBU   1,8-Diazabicyclo[5.4.0]undec-7-ene       DCE   Dichloroethene       DCM   Dichloromethane       dd   Doublet of doublets       DEF   N,N-Diethylformamide       DMF   Dimethylformamide       DMSO   Dimethylsulfoxide       dppf   1,1′-Bis(diphenylphosphino)ferrocene       dt   Doublet-triplet       DTT   Dithiothreitol       EC 50     The half maximal effective concentration       EGFR   Epidermal growth factor receptor       eq   Equivalents       ES/MS   Electrospray mass spectrometry       Et   Ethyl       FBS   Fetal bovine serum       g   Grams       HEPES   2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid       HPLC   High pressure liquid chromatography       hrs   Hours       Hz   Hertz       IBD   Inflammatory bowel disease       i-pr   Isopropyl       J   Coupling constant (MHz)       Kg/kg   Kilogram       LCMS   Liquid chromatography-mass spectrometry       LPS   Lipopolysaccharide       M   Molar       m   multiplet       M+   Mass peak       M + H+   Mass peak plus hydrogen       Me   Methyl       mg   Milligram       MHz   Megahertz       min   Minute       ml/mL   Milliliter       mM   Millimolar       mmol   Millimole       MOPS   3-Morpholinopropane-1-sulfonic acid       MS   Mass spectroscopy       Ms   Mesyl       nBu/Bu   Butyl       nL   Nanoliter       nm   Nanometer       NMR   Nuclear magnetic resonance       NP-40   Nonyl phenoxypolyethoxylethanol       Ns   Nosyl       Pd—C/Pd/C   Palladium on Carbon       pg   Pictogram       Ph   Phenyl       PPTS   Pyridinium p-toluenesulfonate       PS   Polystyrene       p-TSOH/pTSA   p-Toluenesulfonic acid       q   Quartet       q.s.   Quantity sufficient to achieve a stated function       RBF   Round bottom flask       RP   Reverse phase       RPMI   Roswell Park Memorial Institute medium       rt   Room temperature       s   Singlet       sat.   Saturated       t   Triplet       TBAF   Tetra-n-butylammonium fluoride       TBS   tert-Butyldimethylsilyl       t-Bu   tert-Butyl       TC   Thiophene-2-carboxylate       TEA   Triethanolamine       Tf   Trifluoromethanesulfonyl       TFA   Trifluoroacetic acid       THF   Tetrahydrofuran       Tpl2   Tumor Progression Locus 2       TR-FRET   Time-resolved fluorescence energy transfer       Ts   Tosyl       δ   Chemical shift (ppm)       μL/μl   Microliter       μM   Micromolar                    
Compounds
 
     Provided herein are compounds that function as modulators of Cot. In one aspect, provided is a compound having structure of Formula I: 
                         
wherein
 
R 1  is hydrogen, —O—R 7 , —N(R 8 )(R 9 ), —C(O)—R 7 , —S(O) 2 —R 7 , —C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl;
         wherein each C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, heterocyclyl, aryl, and heteroaryl may be optionally substituted with one to four Z 1 ;
 
R 2  is hydrogen, —C(O)—R 7 , —C(O)O—R 7 , —C(O)N(R 7 ) 2 , C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl;
   wherein each C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl may be optionally substituted with one to four Z 2 ;
 
or R 1  and R 2  together with the nitrogen to which they are attached to form a heterocyclyl or heteroaryl, wherein each heterocyclyl or heteroaryl is optionally substituted with one to four Z 2 ;
 
R 3  is heterocyclyl or heteroaryl, wherein each heterocyclyl or heteroaryl is optionally substituted with one to four Z 3 ;
 
R 4  is aryl, wherein said aryl is optionally substituted with one to four Z 4 ;
 
R 5  is hydrogen, halo, —CN, —NO 2 , —O—R 7 , —N(R 8 )(R 9 ), —S(O)—R 7 , —S(O) 2 R 7 , —S(O) 2 N(R 7 ) 2 , —C(O)R 7 , —OC(O)—R 7 , —C(O)O—R 7 , —OC(O)O—R 7 , —OC(O)N(R 1 )(R 11 ), —C(O)N(R 7 ) 2 , —N(R 7 )C(O)(R 7 ), C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-9  alkylthio, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl;
   wherein each C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-9  alkylthio, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl may be optionally substituted with one to four Z 5 ;
 
R 6  is hydrogen, —C(O)—R 7 , —C(O)O—R 7 , —C(O)N(R 7 ) 2 , C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl;
   wherein each C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl may be optionally substituted with one to four Z 6 ;
 
each R 7  is independently hydrogen, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl;
   wherein each C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl may be optionally substituted with one to four Z 7 ;
 
R 8  and R 9  at each occurrence are independently hydrogen, —S(O) 2 R 10 , —C(O)—R 10 , —C(O)O—R 10 , —C(O)N(R 10 )(R 11 ), C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl;
   wherein each C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl may be optionally substituted with one to four Z 8 ;
 
R 10  and R 11  at each occurrence are independently hydrogen, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl,
   wherein each C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl optionally is substituted with one to four Z 1b ;
 
each Z 1 , Z 2 , Z 3 , Z 4 , Z 5 , Z 6 , Z 7  and Z 8  is independently hydrogen, oxo, halo, —NO 2 , —N 3 , —CN, thioxo, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, —O—R 12 , —C(O)—R 12 , —C(O)O—R 12 , —C(O)—N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —N(R 12 )C(O)—R 12 , —N(R 12 )C(O)O—R 12 , —N(R 12 )C(O)N(R 13 )(R 14 ), —N(R 12 )S(O) 2 (R 12 ), —NR 12 S(O) 2 N(R 13 )(R 14 ), —NR 12 S(O) 2 O(R 12 ), —OC(O)R 12 , —OC(O)—N(R 13 )(R 14 ), —P(O)(OR 12 ) 2 , —OP(O)(OR 12 ) 2 , —CH 2 P(O)(OR 12 ) 2 , —OCH 2 P(O)(OR 12 ) 2 , —C(O)OCH_P(O)(OR 12 ) 2 , —P(O)(R 12 )(OR 12 ), —OP(O)(R 12 )(OR 12 ), —CH 2 P(O)(R 12 )(OR 12 ), —OCH 2 P(O)(R 12 )(OR 12 ), —C(O)OCH 2 P(O)(R 12 )(OR 12 ), —P(O)(N(R 12 ) 2 ) 2 , —OP(O)(N(R 12 ) 2 ) 2 , —CH 2 P(O)(N(R 12 ) 2 ) 2 , —OCH 2 P(O)(N(R 12 ) 2 ) 2 , —C(O)OCH 2 P(O)(N(R 12 ) 2 ) 2 , —P(O)(N(R 12 ) 2 )(OR 12 ), —OP(O)(N(R 12 ) 2 )(OR 12 ), —CH 2 P(O)(N(R 12 ) 2 )(OR 12 ), —OCH 2 P(O)(N(R 12 ) 2 )(OR 12 ), —C(O)OCH 2 P(O)(N(R 12 ) 2 )(OR 12 ), —P(O)(R 12 )(N(R 12 ) 2 ), —OP(O)(R 12 )(N(R 12 ) 2 ), —CH 2 P(O)(R 12 )(N(R 12 ) 2 ), —OCH 2 P(O)(R 12 )(N(R 12 ) 2 ), —C(O)OCH 2 P(O)(R 12 )(N(R 12 ) 2 ), —Si(R 12 ) 3 , —S—R 12 , —S(O)R 12 , —S(O)(NH)R 12 , —S(O) 2 R 12  or —S(O) 2 N(R 13 )(R 14 );
   wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1a  groups;
 
each Z 1a  is independently oxo, halo, thioxo, —NO 2 , —CN, —N 3 , C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, —O—R 12 , —C(O)R 12 , —C(O)O—R 12 , —C(O)N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —N(R 12 )—C(O)R 12 , —N(R 12 )C(O)O(R 12 ), —N(R 12 )C(O)N(R 13 )(R 14 ), —N(R 12 )S(O) 2 (R 12 ), —N(R 12 )S(O) 2 —N(R 13 )(R 14 ), —N(R 12 )S(O) 2 O(R 12 ), —OC(O)R 12 , —OC(O)OR 12 , —OC(O)—N(R 13 )(R 14 ), —Si(R 12 ) 3 , —S—R 12 , —S(O)R 12 , —S(O)(NH)R 12 , —S(O) 2 R 12  or —S(O) 2 N(R 13 )(R 14 );
   wherein any alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1b  groups;
 
each R 12  is independently hydrogen, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, aryl, heteroaryl or heterocyclyl,
   wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1b  groups;
 
R 13  and R 14  at each occurrence are each independently hydrogen, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, aryl, heteroaryl or heterocyclyl;
   wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1b  groups, or R 13  and R 14  together with the nitrogen to which they are attached form a heterocyclyl, wherein said heterocyclyl is optionally substituted with one to four Z 1b  groups;
 
each R 15  is independently halo, —CN, —NO 2 , —O—R 7 , —N(R 8 )(R 9 ), —S(O)—R 7 , —S(O) 2 R 7 , —S(O) 2 N(R 7 ) 2 , —C(O)R 7 , —OC(O)—R 7 , —C(O)O—R 7 , —OC(O)O—R 7 , —OC(O)N(R 10 )(R 11 ), —C(O)N(R 7 ) 2 , —N(R 7 )C(O)(R 7 ), C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-9  alkylthio, C 1-6  haloalkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl; and
 
each Z 1b  is independently oxo, thioxo, hydroxy, halo, —NO 2 , —N 3 , —CN, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, —O(C 1-9  alkyl), —O(C 2-6  alkenyl), —O(C 2-6  alkynyl), —O(C 3-15  cycloalkyl), —O(C 1-8  haloalkyl), —O(aryl), —O(heteroaryl), —O(heterocyclyl), —NH 2 , —NH(C 1-9  alkyl), —NH(C 2-6  alkenyl), —NH(C 2-6  alkynyl), —NH(C 3-15  cycloalkyl), —NH(C 1-8  haloalkyl), —NH(aryl), —NH(heteroaryl), —NH(heterocyclyl), —N(C 1-9  alkyl) 2 , —N(C 3-15  cycloalkyl) 2 , —N(C 2-6  alkenyl) 2 , —N(C 2-6  alkynyl) 2 , —N(C 3-15  cycloalkyl) 2 , —N(C 1-8  haloalkyl) 2 , —N(aryl) 2 , —N(heteroaryl) 2 , —N(heterocyclyl) 2 , —N(C 1-9  alkyl)(C 3-15  cycloalkyl), —N(C 1-9  alkyl)(C 2-6  alkenyl), —N(C 1-9  alkyl)(C 2-6  alkynyl), —N(C 1-9  alkyl)(C 3-15  cycloalkyl), —N(C 1-9  alkyl)(C 1-8  haloalkyl), —N(C 1-9  alkyl)(aryl), —N(C 1-9  alkyl)(heteroaryl), —N(C 1-9  alkyl)(heterocyclyl), —C(O)(C 1-9  alkyl), —C(O)(C 2-6  alkenyl), —C(O)(C 2-6  alkynyl), —C(O)(C 3-15  cycloalkyl), —C(O)(C 1-8  haloalkyl), —C(O)(aryl), —C(O)(heteroaryl), —C(O)(heterocyclyl), —C(O)O(C 1-9  alkyl), —C(O)O(C 2-6  alkenyl), —C(O)O(C 2-6  alkynyl), —C(O)O(C 3-15  cycloalkyl), —C(O)O(C 1-8  haloalkyl), —C(O)O(aryl), —C(O)O(heteroaryl), —C(O)O(heterocyclyl), —C(O)NH 2 , —C(O)NH(C 1-9  alkyl), —C(O)NH(C 2-6  alkenyl), —C(O)NH(C 2-6  alkynyl), —C(O)NH(C 3-15  cycloalkyl), —C(O)NH(C 1-8  haloalkyl), —C(O)NH(aryl), —C(O)NH(heteroaryl), —C(O)NH(heterocyclyl), —C(O)N(C 1-9  alkyl) 2 , —C(O)N(C 3-15  cycloalkyl) 2 , —C(O)N(C 2-6  alkenyl) 2 , —C(O)N(C 2-6  alkynyl) 2 , —C(O)N(C 3-15  cycloalkyl) 2 , —C(O)N(C 1-8  haloalkyl) 2 , —C(O)N(aryl) 2 , —C(O)N(heteroaryl) 2 , —C(O)N(heterocyclyl) 2 , —NHC(O)(C 1-9  alkyl), —NHC(O)(C 2-6  alkenyl), —NHC(O)(C 2-6  alkynyl), —NHC(O)(C 3-15  cycloalkyl), —NHC(O)(C 1-8  haloalkyl), —NHC(O)(aryl), —NHC(O)(heteroaryl), —NHC(O)(heterocyclyl), —NHC(O)O(C 1-9  alkyl), —NHC(O)O(C 2-6  alkenyl), —NHC(O)O(C 2-6  alkynyl), —NHC(O)O(C 3-15  cycloalkyl), —NHC(O)O(C 1-8  haloalkyl), —NHC(O)O(aryl), —NHC(O)O(heteroaryl), —NHC(O)O(heterocyclyl), —NHC(O)NH(C 1-9  alkyl), —NHC(O)NH(C 2-6  alkenyl), —NHC(O)NH(C 2-6  alkynyl), —NHC(O)NH(C 3-15  cycloalkyl), —NHC(O)NH(C 1-8  haloalkyl), —NHC(O)NH(aryl), —NHC(O)NH(heteroaryl), —NHC(O)NH(heterocyclyl), —SH, —S(C 1-9  alkyl), —S(C 2-6  alkenyl), —S(C 2-6  alkynyl), —S(C 3-15  cycloalkyl), —S(C 1-8  haloalkyl), —S(aryl), —S(heteroaryl), —S(heterocyclyl), —NHS(O)(C 1-9  alkyl), —N(C 1-9  alkyl)(S(O)(C 1-9  alkyl), —S(O)N(C 1-9  alkyl) 2 , —S(O)(C 1-9  alkyl), —S(O)(NH)(C 1-9  alkyl), —S(O)(C 2-6  alkenyl), —S(O)(C 2-6  alkynyl), —S(O)(C 3-15  cycloalkyl), —S(O)(C 1-8  haloalkyl), —S(O)(aryl), —S(O)(heteroaryl), —S(O)(heterocyclyl), —S(O) 2 (C 1-9  alkyl), —S(O) 2 (C 2-6  alkenyl), —S(O) 2 (C 2-6  alkynyl), —S(O) 2 (C 3-15  cycloalkyl), —S(O) 2 (C 1-8  haloalkyl), —S(O) 2 (aryl), —S(O) 2 (heteroaryl), —S(O) 2 (heterocyclyl), —S(O) 2 NH(C 1-9  alkyl), or —S(O) 2 N(C 1-9  alkyl) 2 ;
   wherein any alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with one to four halo, C 1-9  alkyl, C 1-8  haloalkyl, —OH, —NH 2 , —NH(C 1-9  alkyl), —NH(C 3-15  cycloalkyl), —NH(C 1-8  haloalkyl), —NH(aryl), —NH(heteroaryl), —NH(heterocyclyl), —N(C 1-9  alkyl) 2 , —N(C 3-15  cycloalkyl) 2 , —NHC(O)(C 3-15  cycloalkyl), —NHC(O)(C 1-8  haloalkyl), —NHC(O)(aryl), —NHC(O)(heteroaryl), —NHC(O)(heterocyclyl), —NHC(O)O(C 1-9  alkyl), —NHC(O)O(C 2-6  alkynyl), —NHC(O)O(C 3-15  cycloalkyl), —NHC(O)O(C 1-8  haloalkyl), —NHC(O)O(aryl), —NHC(O)O(heteroaryl), —NHC(O)O(heterocyclyl), —NHC(O)NH(C 1-9  alkyl), —S(O)(NH)(C 1-9  alkyl), S(O) 2 (C 1-9  alkyl), —S(O) 2 (C 3-15  cycloalkyl), —S(O) 2 (C 1-8  haloalkyl), —S(O) 2 (aryl), —S(O) 2 (heteroaryl), —S(O) 2 (heterocyclyl), —S(O) 2 NH(C 1-9  alkyl), —S(O) 2 N(C 1-9  alkyl) 2 , —O(C 3-15  cycloalkyl), —O(C 1-8  haloalkyl), —O(aryl), —O(heteroaryl), —O(heterocyclyl), or —O(C 1-9  alkyl);
 
m is 0, 1, or 2;
 
or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof.
       

     In certain embodiments, the compound of Formula I is represented by Formula IA: 
                         
wherein R 1 -R 6 , R 15  and m are as described herein.
 
     In certain embodiments, the compound of Formula I is represented by Formula IB: 
                         
wherein R 1 -R 6 , R 15  and m are as described herein.
 
     In certain embodiments, m is 0. In certain embodiments, R 2  is hydrogen. 
     In certain embodiments, provided is a compound of Formula II: 
                         
wherein R 1 , R 3 , R 4 , R 5  and R 6  are as defined herein.
 
     In certain embodiments, provided is a compound of Formula IIA: 
                         
wherein R 1 , R 3 , R 4 , R 5  and R 6  are as defined herein.
 
     In certain embodiments, the compound of Formula I is represented by Formula III: 
     
       
         
         
             
             
         
       
         
         
           
             wherein R 1 , R 4 , R 5  and R 6  are as defined herein,
 
W, X and Y are each independently N or C;
 
n is 1, 2, or 3;
 
each Z 3  is independently hydrogen, oxo, halo, —NO 2 , —N 3 , —CN, thioxo, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, —O—R 12 , —C(O)—R 12 , —C(O)O—R 12 , —C(O)—N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —N(R 12 )C(O)—R 12 , —N(R 12 )C(o)O—R 12 , —N(R 12 )C(O)N(R 13 )(R 14 ), —N(R 12 )S(O) 2 (R 12 ), —NR 12 S(O) 2 N(R 13 )(R 14 ), —NR 12 S(O) 20 (R 12 ), —OC(O)R 12 , —OC(O)—N(R 13 )(R 14 ), —P(O)(OR 12 ) 2 , —OP(O)(OR 12 ) 2 , —CH 2 (O)(OR 12 ) 2 , —OCH 2 P(O)(OR 12 ) 2 , —C(O)OCH 2 P(O)(OR 12 ) 2 , —P(O)(R 12 )(OR 12 ), —OP(O)(R 12 )(OR 12 ), —CH 2 P(O)(R 12 )(OR 12 ), —OCH 2 P(O)(R 12 )(OR 12 ), —C(O)OCH 2 P(O)(R 12 )(OR 12 ), —P(O)(N(R 12 ) 2 ) 2 , —OP(O)(N(R 12 ) 2 ) 2 , —CH 2 P(O)(N(R 12 ) 2 ) 2 , —OCH 2 P(O)(N(R 12 ) 2 ) 2 , —C(O)OCH 2 )P(O)(N(R 12 ) 2 ) 2 , —P(O)(N(R 12 ) 2 )(OR 12 ), —OP(O)(N(R 12 ) 2 )(OR 12 ), —CH 2 P(O)(N(R 12 ) 2 )(OR 12 ), —OCH 2 P(O)(N(R 12 ) 2 )(OR 12 ), —C(O)OCH 2 P(O)(N(R 12 ) 2 )(OR) 2 )(OR 12 ), —P(O)(R 12 )(N(R 12 ) 2 ), —OP(O)(R 12 )(N(R 12 ) 2 ), —CH 2 P(O)(R 12 )(N(R 12 ) 2 ), —OCH 2 P(O)(R 12 )(N(R 12 ) 2 ), —C(O)OCH 2 P(O)(R 12 )(N(R 12 ) 2 ), —Si(R 12 ) 3 , —S—R 12 , —S(O)R 12 , —S(O)(NH)R 12 , —S(O) 2 R 12  or —S(O) 2 N(R 13 )(R 14 );
 
             wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1a  groups;
 
each Z 1a  is independently oxo, halo, thioxo, —NO 2 , —CN, —N 3 , C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, —O—R 12 , —C(O)R 12 , —C(O)O—R 12 , —C(O)N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —N(R 12 )—C(O)R 12 , —N(R 12 )C(O)O(R 12 ), —N(R 12 )C(O)N(R 13 )(R 14 ), —N(R 12 )S(O) 2 (R 12 ), —N(R 12 )S(O) 2 —N(R 13 )(R 14 ), —N(R 12 )S(O) 2 O(R 12 ), —OC(O)R 12 , —OC(O)OR 12 , —OC(O)—N(R 13 )(R 14 ), —Si(R 12 ) 3 , —S—R 12 , —S(O)R 12 , —S(O)(NH)R 12 , —S(O) 2 R 12  or —S(O) 2 N(R 13 )(R 14 );
 
             wherein any alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1b  groups;
 
each R 12  is independently hydrogen, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, aryl, heteroaryl or heterocyclyl;
 
             wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1b  groups;
 
R 13  and R 14  at each occurrence are each independently hydrogen, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, aryl, heteroaryl or heterocyclyl;
 
             wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1b  groups, or R 13  and R 14  together with the nitrogen to which they are attached form a heterocyclyl, wherein said heterocyclyl is optionally substituted with one to four Z 1b  groups; and
 
each Z 1b  is independently oxo, thioxo, hydroxy, halo, —NO 2 , —N 3 , —CN, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, —O(C 1-9  alkyl), —O(C 2-6  alkenyl), —O(C 2-6  alkynyl), —O(C 3-15  cycloalkyl), —O(C 1-8  haloalkyl), —O(aryl), —O(heteroaryl), —O(heterocyclyl), —NH 2 , —NH(C 1-9  alkyl), —NH(C 2-6  alkenyl), —NH(C 2-6  alkynyl), —NH(C 3-15  cycloalkyl), —NH(C 1-8  haloalkyl), —NH(aryl), —NH(heteroaryl), —NH(heterocyclyl), —N(C 1-9  alkyl) 2 , —N(C 3-15  cycloalkyl) 2 , —N(C 2-6  alkenyl) 2 , —N(C 2-6  alkynyl) 2 , —N(C 3-15  cycloalkyl) 2 , —N(C 1-8  haloalkyl) 2 , —N(aryl) 2 , —N(heteroaryl) 2 , —N(heterocyclyl) 2 , —N(C 1-9  alkyl)(C 3-15  cycloalkyl), —N(C 1-9  alkyl)(C 2-6  alkenyl), —N(C 1-9  alkyl)(C 2-6  alkynyl), —N(C 1-9  alkyl)(C 3-15  cycloalkyl), —N(C 1-9  alkyl)(C 1-8  haloalkyl), —N(C 1-9  alkyl)(aryl), —N(C 1-9  alkyl)(heteroaryl), —N(C 1-9  alkyl)(heterocyclyl), —C(O)(C 1-9  alkyl), —C(O)(C 2-6  alkenyl), —C(O)(C 2-6  alkynyl), —C(O)(C 3-15  cycloalkyl), —C(O)(C 1-8  haloalkyl), —C(O)(aryl), —C(O)(heteroaryl), —C(O)(heterocyclyl), —C(O)O(C 1-9  alkyl), —C(O)O(C 2-6  alkenyl), —C(O)O(C 2-6  alkynyl), —C(O)O(C 3-15  cycloalkyl), —C(O)O(C 1-8  haloalkyl), —C(O)O(aryl), —C(O)O(heteroaryl), —C(O)O(heterocyclyl), —C(O)NH 2 , —C(O)NH(C 1-9  alkyl), —C(O)NH(C 2-6  alkenyl), —C(O)NH(C 2-6  alkynyl), —C(O)NH(C 3-15  cycloalkyl), —C(O)NH(C 1-8  haloalkyl), —C(O)NH(aryl), —C(O)NH(heteroaryl), —C(O)NH(heterocyclyl), —C(O)N(C 1-9  alkyl) 2 , —C(O)N(C 3-15  cycloalkyl) 2 , —C(O)N(C 2-6  alkenyl) 2 , —C(O)N(C 2-6  alkynyl) 2 , —C(O)N(C 3-15  cycloalkyl) 2 , —C(O)N(C 1-8  haloalkyl) 2 , —C(O)N(aryl) 2 , —C(O)N(heteroaryl) 2 , —C(O)N(heterocyclyl) 2 , —NHC(O)(C 1-9  alkyl), —NHC(O)(C 2-6  alkenyl), —NHC(O)(C 2-6  alkynyl), —NHC(O)(C 3-15  cycloalkyl), —NHC(O)(C 1-8  haloalkyl), —NHC(O)(aryl), —NHC(O)(heteroaryl), —NHC(O)(heterocyclyl), —NHC(O)O(C 1-9  alkyl), —NHC(O)O(C 2-6  alkenyl), —NHC(O)O(C 2-6  alkynyl), —NHC(O)O(C 3-15  cycloalkyl), —NHC(O)O(C 1-8  haloalkyl), —NHC(O)O(aryl), —NHC(O)O(heteroaryl), —NHC(O)O(heterocyclyl), —NHC(O)NH(C 1-9  alkyl), —NHC(O)NH(C 2-6  alkenyl), —NHC(O)NH(C 2-6  alkynyl), —NHC(O)NH(C 3-15  cycloalkyl), —NHC(O)NH(C 1-8  haloalkyl), —NHC(O)NH(aryl), —NHC(O)NH(heteroaryl), —NHC(O)NH(heterocyclyl), —SH, —S(C 1-9  alkyl), —S(C 2-6  alkenyl), —S(C 2-6  alkynyl), —S(C 3-15  cycloalkyl), —S(C 1-8  haloalkyl), —S(aryl), —S(heteroaryl), —S(heterocyclyl), —NHS(O)(C 1-9  alkyl), —N(C 1-9  alkyl)(S(O)(C 1-9  alkyl), —S(O)N(C 1-9  alkyl) 2 , —S(O)(C 1-9  alkyl), —S(O)(NH)(C 1-9  alkyl), —S(O)(C 2-6  alkenyl), —S(O)(C 2-6  alkynyl), —S(O)(C 3-15  cycloalkyl), —S(O)(C 1-8  haloalkyl), —S(O)(aryl), —S(O)(heteroaryl), —S(O)(heterocyclyl), —S(O) 2 (C 1-9  alkyl), —S(O) 2 (C 2-6  alkenyl), —S(O) 2 (C 2-6  alkynyl), —S(O) 2 (C 3-15  cycloalkyl), —S(O) 2 (C 1-8  haloalkyl), —S(O) 2 (aryl), —S(O) 2 (heteroaryl), —S(O) 2 (heterocyclyl), —S(O) 2 NH(C 1-9  alkyl), or —S(O) 2 N(C 1-9  alkyl) 2 ;
 
             wherein any alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with one to four halo, C 1-9  alkyl, C 1-8  haloalkyl, —OH, —NH 2 , —NH(C 1-9  alkyl), —NH(C 3-15  cycloalkyl), —NH(C 1-8  haloalkyl), —NH(aryl), —NH(heteroaryl), —NH(heterocyclyl), —N(C 1-9  alkyl) 2 , —N(C 3-15  cycloalkyl) 2 , —NHC(O)(C 3-15  cycloalkyl), —NHC(O)(C 1-8  haloalkyl), —NHC(O)(aryl), —NHC(O)(heteroaryl), —NHC(O)(heterocyclyl), —NHC(O)O(C 1-9  alkyl), —NHC(O)O(C 2-6  alkynyl), —NHC(O)O(C 3-15  cycloalkyl), —NHC(O)O(C 1-8  haloalkyl), —NHC(O)O(aryl), —NHC(O)O(heteroaryl), —NHC(O)O(heterocyclyl), —NHC(O)NH(C 1-9  alkyl), —S(O)(NH)(C 1-9  alkyl), S(O) 2 (C 1-9  alkyl), —S(O) 2 (C 3-15  cycloalkyl), —S(O) 2 (C 1-8  haloalkyl), —S(O) 2 (aryl), —S(O) 2 (heteroaryl), —S(O) 2 (heterocyclyl), —S(O) 2 NH(C 1-9  alkyl), —S(O) 2 N(C 1-9  alkyl) 2 , —O(C 3-15  cycloalkyl), —O(C 1-8  haloalkyl), —O(aryl), —O(heteroaryl), —O(heterocyclyl), or —O(C 1-9  alkyl);
 
or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof.
 
           
         
       
    
     In certain embodiments, the compound of Formula I is represented by Formula IIIA: 
     
       
         
         
             
             
         
       
         
         
           
             wherein R 1 , R 4 , R 5  and R 6  are as defined herein,
 
W, X and Y are each independently N or C;
 
n is 1, 2, or 3;
 
each Z 3  is independently hydrogen, oxo, halo, —NO 2 , —N 3 , —CN, thioxo, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, —O—R 12 , —C(O)—R 12 , —C(O)O—R 12 , —C(O)—N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —N(R 12 )C(O)—R 12 , —N(R 12 )C(O)O—R 12 , —N(R 12 )C(O)N(R 13 )(R 14 ), —N(R 12 )S(O) 2 (R 12 ), —NR 12 S(O) 2 N(R 13 )(R 14 ), —NR 12 S(O) 2 O(R 12 ), —OC(O)R 12 , —OC(O)—N(R 13 )(R 14 ), —P(O)(OR 12 ) 2 , —OP(O)(OR 12 ) 2 , —CH 2 P(O)(OR 12 ) 2 , —OCH 2 P(O)(OR 12 ) 2 , —C(O)OCH 2 P(O)(OR 12 ) 2 . —P(O)(R 12 )(OR 12 ), —OP(O)(R 12 )(OR 12 ), —CH 2 P(O)(R 12 )(OR 12 ), —OCH 2 P(O)(R 12 )(OR 12 ), —C(O)OCH 2 P(O)(R 12 )(OR 12 ), —P(O)(N(R 12 ) 2 ) 2 , —OP(O)(N(R 12 ) 2 ) 2 , —CH 2 P(O)(N(R 12 ) 2 ) 2 , —OCH 2 P(O)(N(R 12 ) 2 ) 2 , —C(O)OCH 2 P(O)(N(R 12 ) 2 ) 2 , —P(O)(N(R 12 ) 2 )(OR 12 ), —OP(O)(N(R 12 ) 2 )(OR 12 ), —CH 2 P(O)(N(R 12 ) 2 )(OR 12 ), —OCH 2 P(O)(N(R 12 ) 2 )(OR 12 ), —C(O)OCH 2 P(O)(N(R 12 ) 2 )(OR 12 ), —P(O)(R 12 )(N(R 12 ) 2 ), —OP(O)(R 12 )(N(R 12 ) 2 ), —CH 2 P(O)(R 12 )(N(R 12 ) 2 ), —OCH 2 P(O)(R 12 )(N(R 12 ) 2 ), —C(O)OC 2 P(O)(R 12 )(N(R 12 ) 2 ), —Si(R 12 ) 3 , —S—R 12 , —S(O)R 12 , —S(O)(NH)R 12 , —S(O) 2 R 12  or —S(O) 2 N(R 13 )(R 14 );
 
             wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1a  groups;
 
each Z 1a  is independently oxo, halo, thioxo, —NO 2 , —CN, —N 3 , C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, —O—R 12 , —C(O)R 12 , —C(O)O—R 12 , —C(O)N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —N(R 12 )—C(O)R 12 , —N(R 12 )C(O)O(R 12 ), —N(R 12 )C(O)N(R 13 )(R 14 ), —N(R 12 )S(O) 2 (R 12 ), —N(R 12 )S(O) 2 —N(R 13 )(R 14 ), —N(R 12 )S(O) 2 O(R 12 ), —OC(O)R 12 , —OC(O)OR 12 , —OC(O)—N(R 13 )(R 14 ), —Si(R 12 ) 3 , —S—R 12 , —S(O)R 12 , —S(O)(NH)R 12 , —S(O) 2 R 12  or —S(O) 2 N(R 13 )(R 14 );
 
             wherein any alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1b  groups;
 
each R 12  is independently hydrogen, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, aryl, heteroaryl or heterocyclyl;
 
             wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1b  groups;
 
R 13  and R 14  at each occurrence are each independently hydrogen, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, aryl, heteroaryl or heterocyclyl;
 
             wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1b  groups, or R 13  and R 14  together with the nitrogen to which they are attached form a heterocyclyl, wherein said heterocyclyl is optionally substituted with one to four Z 1b  groups; and
 
each Z 1b  is independently oxo, thioxo, hydroxy, halo, —NO 2 , —N 3 , —CN, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, —O(C 1-9  alkyl), —O(C 2-6  alkenyl), —O(C 2-6  alkynyl), —O(C 3-15  cycloalkyl), —O(C 1-8  haloalkyl), —O(aryl), —O(heteroaryl), —O(heterocyclyl), —NH 2 , —NH(C 1-9  alkyl), —NH(C 2-6  alkenyl), —NH(C 2-6  alkynyl), —NH(C 3-15  cycloalkyl), —NH(C 1-8  haloalkyl), —NH(aryl), —NH(heteroaryl), —NH(heterocyclyl), —N(C 1-9  alkyl) 2 , —N(C 3-15  cycloalkyl) 2 , —N(C 2-6  alkenyl) 2 , —N(C 2-6  alkynyl) 2 , —N(C 3-15  cycloalkyl) 2 , —N(C 1-8  haloalkyl) 2 , —N(aryl) 2 , —N(heteroaryl) 2 , —N(heterocyclyl) 2 , —N(C 1-9  alkyl)(C 3-15  cycloalkyl), —N(C 1-9  alkyl)(C 2-6  alkenyl), —N(C 1-9  alkyl)(C 2-6  alkynyl), —N(C 1-9  alkyl)(C 3-15  cycloalkyl), —N(C 1-9  alkyl)(C 1-8  haloalkyl), —N(C 1-9  alkyl)(aryl), —N(C 1-9  alkyl)(heteroaryl), —N(C 1-9  alkyl)(heterocyclyl), —C(O)(C 1-9  alkyl), —C(O)(C 2-6  alkenyl), —C(O)(C 2-6  alkynyl), —C(O)(C 3-15  cycloalkyl), —C(O)(C 1-8  haloalkyl), —C(O)(aryl), —C(O)(heteroaryl), —C(O)(heterocyclyl), —C(O)O(C 1-9  alkyl), —C(O)O(C 2-6  alkenyl), —C(O)O(C 2-6  alkynyl), —C(O)O(C 3-15  cycloalkyl), —C(O)O(C 1-8  haloalkyl), —C(O)O(aryl), —C(O)O(heteroaryl), —C(O)O(heterocyclyl), —C(O)NH 2 , —C(O)NH(C 1-9  alkyl), —C(O)NH(C 2-6  alkenyl), —C(O)NH(C 2-6  alkynyl), —C(O)NH(C 3-15  cycloalkyl), —C(O)NH(C 1-8  haloalkyl), —C(O)NH(aryl), —C(O)NH(heteroaryl), —C(O)NH(heterocyclyl), —C(O)N(C 1-9  alkyl) 2 , —C(O)N(C 3-15  cycloalkyl) 2 , —C(O)N(C 2-6  alkenyl) 2 , —C(O)N(C 2-6  alkynyl) 2 , —C(O)N(C 3-15  cycloalkyl) 2 , —C(O)N(C 1-8  haloalkyl) 2 , —C(O)N(aryl) 2 , —C(O)N(heteroaryl) 2 , —C(O)N(heterocyclyl) 2 , —NHC(O)(C 1-9  alkyl), —NHC(O)(C 2-6  alkenyl), —NHC(O)(C 2-6  alkynyl), —NHC(O)(C 3-15  cycloalkyl), —NHC(O)(C 1-8  haloalkyl), —NHC(O)(aryl), —NHC(O)(heteroaryl), —NHC(O)(heterocyclyl), —NHC(O)O(C 1-9  alkyl), —NHC(O)O(C 2-6  alkenyl), —NHC(O)O(C 2-6  alkynyl), —NHC(O)O(C 3-15  cycloalkyl), —NHC(O)O(C 1-8  haloalkyl), —NHC(O)O(aryl), —NHC(O)O(heteroaryl), —NHC(O)O(heterocyclyl), —NHC(O)NH(C 1-9  alkyl), —NHC(O)NH(C 2-6  alkenyl), —NHC(O)NH(C 2-6  alkynyl), —NHC(O)NH(C 3-15  cycloalkyl), —NHC(O)NH(C 1-8  haloalkyl), —NHC(O)NH(aryl), —NHC(O)NH(heteroaryl), —NHC(O)NH(heterocyclyl), —SH, —S(C 1-9  alkyl), —S(C 2-6  alkenyl), —S(C 2-6  alkynyl), —S(C 3-15  cycloalkyl), —S(C 1-8  haloalkyl), —S(aryl), —S(heteroaryl), —S(heterocyclyl), —NHS(O)(C 1-9  alkyl), —N(C 1-9  alkyl)(S(O)(C 1-9  alkyl), —S(O)N(C 1-9  alkyl) 2 , —S(O)(C 1-9  alkyl), —S(O)(NH)(C 1-9  alkyl), —S(O)(C 2-6  alkenyl), —S(O)(C 2-6  alkynyl), —S(O)(C 3-15  cycloalkyl), —S(O)(C 1-8  haloalkyl), —S(O)(aryl), —S(O)(heteroaryl), —S(O)(heterocyclyl), —S(O) 2 (C 1-9  alkyl), —S(O) 2 (C 2-6  alkenyl), —S(O) 2 (C 2-6  alkynyl), —S(O) 2 (C 3-15  cycloalkyl), —S(O) 2 (C 1-8  haloalkyl), —S(O) 2 (aryl), —S(O) 2 (heteroaryl), —S(O) 2 (heterocyclyl), —S(O) 2 NH(C 1-9  alkyl), or —S(O) 2 N(C 1-9  alkyl) 2 ;
 
             wherein any alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with one to four halo, C 1-9  alkyl, C 1-8  haloalkyl, —OH, —NH 2 , —NH(C 1-9  alkyl), —NH(C 3-15  cycloalkyl), —NH(C 1-8  haloalkyl), —NH(aryl), —NH(heteroaryl), —NH(heterocyclyl), —N(C 1-9  alkyl) 2 , —N(C 3-15  cycloalkyl) 2 , —NHC(O)(C 3-15  cycloalkyl), —NHC(O)(C 1-8  haloalkyl), —NHC(O)(aryl), —NHC(O)(heteroaryl), —NHC(O)(heterocyclyl), —NHC(O)O(C 1-9  alkyl), —NHC(O)O(C 2-6  alkynyl), —NHC(O)O(C 3-15  cycloalkyl), —NHC(O)O(C 1-8  haloalkyl), —NHC(O)O(aryl), —NHC(O)O(heteroaryl), —NHC(O)O(heterocyclyl), —NHC(O)NH(C 1-9  alkyl), —S(O)(NH)(C 1-9  alkyl), S(O) 2 (C 1-9  alkyl), —S(O) 2 (C 3-15  cycloalkyl), —S(O) 2 (C 1-8  haloalkyl), —S(O) 2 (aryl), —S(O) 2 (heteroaryl), —S(O) 2 (heterocyclyl), —S(O) 2 NH(C 1-9  alkyl), —S(O) 2 N(C 1-9  alkyl) 2 , —O(C 3-15  cycloalkyl), —O(C 1-8  haloalkyl), —O(aryl), —O(heteroaryl), —O(heterocyclyl), or —O(C 1-9  alkyl);
 
or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof.
 
           
         
       
    
     In certain embodiments, W is N, X is N—Z 3 , and Y is C—Z 3 . In certain embodiments, W is C—Z 3 , X is N—Z 3 , and Y is C—Z 3 . 
     In certain embodiments, the compound of Formula I is represented by Formula IV or V: 
     
       
         
         
             
             
         
       
         
         
           
             wherein Z 3 , R 1 , R 4 , R 5  and R 6  are as defined herein and Z 9  is hydrogen, halo, —CN, or —O—R 12 . 
           
         
       
    
     In certain embodiments, the compound of Formula I is represented by Formula IVA or VA: 
                         
wherein Z 3 , R 1 , R 4 , R 5  and R 6  are as defined herein and Z 9  is hydrogen, halo, —CN, or —O—R 12 .
 
     In certain embodiments, the compound of Formula I is represented by Formula VI or VII: 
     
       
         
         
             
             
         
       
         
         
           
             wherein Z 3 , R 1 , R 4 , R 5  and R 6  are as defined herein. 
           
         
       
    
     In certain embodiments, the compound of Formula I is represented by Formula VIA or VIIA: 
     
       
         
         
             
             
         
       
         
         
           
             wherein Z 3 , R 1 , R 4 , R 5  and R 6  are as defined herein. 
           
         
       
    
     In certain embodiments, R 6  is hydrogen. 
     In certain embodiments, Z 3  is hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl;
         wherein said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl, may be optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —OC(O)—R 12 , —C(O)O—R 12 , —C(O)—N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl; and
 
wherein said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, —O(C 1-9  alkyl), —C(O)N(C 1-9  alkyl) 2 , C 1-9  alkyl, and heterocyclyl.
       

     In certain embodiments, Z 3  is hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl;
         wherein said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl, may be optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —OC(O)—R 12 , —C(O)O—R 12 , —C(O)—N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl; and
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, hydroxyl, —O(C 1-9  alkyl), —C(O)N(C 1-9  alkyl) 2 , C 1-9  alkyl, and heterocyclyl.   
               

     In certain embodiments, Z 3  is hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl;
         wherein said C 1-9  alkyl, C 3-15  cycloalkyl, aryl, or heterocyclyl, may be optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —OC(O)—R 12 , —C(O)O—R 12 , —C(O)—N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl; and
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, —O(C 1-9  alkyl), —C(O)N(C 1-9  alkyl) 2 , C 1-9  alkyl, and heterocyclyl.   
               

     In certain embodiments, Z 3  is hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl;
         wherein said C 1-9  alkyl, C 3-15  cycloalkyl, aryl, or heterocyclyl, may be optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —OC(O)—R 12 , —C(O)O—R 12 , —C(O)—N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl; and
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, hydroxyl, —O(C 1-9  alkyl), —C(O)N(C 1-9  alkyl) 2 , C 1-9  alkyl, and heterocyclyl.   
               

     In certain embodiments, Z 3  is hydrogen or C 1-9  alkyl;
         wherein said C 1-9  alkyl may be optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —OC(O)—R 12 , —C(O)O—R 12 , —C(O)—N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl; and
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, —O(C 1-9  alkyl), —C(O)N(C 1-9 alkyl) 2 , C 1-9  alkyl, and heterocyclyl.   
               

     In certain embodiments, Z 3  is hydrogen or C 1-9  alkyl optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)O—R 12 , —OC(O)—R 12 , —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , C 1-9  alkyl, heterocyclyl, and heteroaryl. 
     In certain embodiments, Z 3  is C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl;
         wherein said C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl, may be optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —OC(O)—R 12 , —C(O)O—R 12 , —C(O)—N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl; and
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, —O(C 1-9  alkyl), —C(O)N(C 1-9  alkyl) 2 , C 1-9  alkyl, and heterocyclyl.   
               

     In certain embodiments, Z 3  is C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl;
         wherein said C 3-15  cycloalkyl, heterocyclyl, or aryl may be optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —OC(O)—R 12 , —C(O)O—R 12 , —C(O)—N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl; and
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, —O(C 1-9  alkyl), —C(O)N(C 1-9  alkyl) 2 , C 1-9  alkyl, and heterocyclyl.   
               

     In certain embodiments, Z 3  is C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl;
         wherein said C 3-15  cycloalkyl, heterocyclyl, or aryl may be optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —OC(O)—R 12 , —C(O)O—R 12 , —C(O)—N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl; and
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, —O(C 1-9  alkyl), —C(O)N(C 1-9  alkyl) 2 , C 1-9  alkyl, and heterocyclyl.   
               

     In certain embodiments, Z 3  is hydrogen or C 1-9  alkyl optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)O—R 12 , —OC(O)—R 12 , —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , C 1-9  alkyl, heterocyclyl, and heteroaryl. 
     In certain embodiments, Z 3  is C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl; and said C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl may be optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)O—R 12 , —OC(O)—R 12 , —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , C 1-9  alkyl, heterocyclyl, and heteroaryl. 
     In certain embodiments, Z 3  is hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl;
         wherein said C 1-9  alkyl, C 3-15  cycloalkyl, aryl, or heterocyclyl may be optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —OC(O)—R 12 , —C(O)O—R 12 , —C(O)—N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl;
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, —O(C 1-9  alkyl), —C(O)—N(C 1-9  alkyl) 2 , C 1-9  alkyl, and heterocyclyl;
 
R 1  is hydrogen, —O—R 7 , —N(R 8 )(R 9 ), —C(O)—R 7 , —S(O) 2 —R 7 , C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl;
   
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —N(R 13 )(R 14 ), —N(R 12 )C(O)O—R 12 , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, and heteroaryl;
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, aryl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —N(R 13 )(R 14 ), C 1-9  alkyl, C 3-15  cycloalkyl, and aryl;
 
R 4  is aryl;
   
           wherein said aryl is optionally substituted with one to three substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —C(O)O—R 12 , —S(O) 2 —R 12 , —N(R 12 )C(O)—R 12 , —N(R 12 )S(O) 2 R 12 , —C(O)N(R 13 )(R 14 ), —N(R 13 )(R 14 ), C 1-9  alkyl, heterocyclyl, aryl, and heteroaryl;
           wherein said C 1-9  alkyl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, —O—R 12 , —N(R 13 )(R 14 ), C 1-9  alkyl, and heterocyclyl;
 
R 5  is —CN, halo, —O—R 7 , —C(O)R 7 , —N(R 8 )C(O)(R 7 ), —C(O)N(R 8 )(R 9 ), C 1-9  alkyl, C 2-6  alkynyl, C 3-15  cycloalkyl, aryl, or heteroaryl;
   
           wherein said C 1-9  alkyl, aryl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, —O—R 12 , and C 1-9  alkyl;
 
each R 7  is independently hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl;
   wherein said C 1-9  alkyl, or heterocyclyl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, —O—R 12 , —N(R 13 )(R 14 ), C 1-9  alkyl, aryl, and heteroaryl;
 
each R 12  is independently hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl;
   wherein said C 1-9  alkyl, or heterocyclyl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, —O(C 1-9  alkyl), —N(C 1-9  alkyl) 2 , C 1-9  alkyl, aryl, and heteroaryl; and
 
each R 13  and R 14  are independently hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl;
   wherein said C 1-9  alkyl, or heterocyclyl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, —O(C 1-9  alkyl), —N(C 1-9  alkyl) 2 , C 1-9  alkyl, aryl, and heteroaryl;
 
or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof.
       

     In certain embodiments, Z 3  is hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl;
         wherein said C 1-9  alkyl, C 3-15  cycloalkyl, aryl, or heterocyclyl may be optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —OC(O)—R 12 , —C(O)O—R 12 , —C(O)—N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl;
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, —O(C 1-9  alkyl), —C(O)—N(C 1-9  alkyl) 2 , C 1-9  alkyl, and heterocyclyl;
 
R 1  is hydrogen, —O—R 7 , —N(R 8 )(R 9 ), —C(O)—R 7 , —S(O) 2 —R 7 , C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl;
   
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —N(R 13 )(R 14 ), —N(R 12 )C(O)O—R 12 , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, and heteroaryl;
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, aryl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —N(R 13 )(R 14 ), C 1-9  alkyl, C 3-15  cycloalkyl, and aryl;
 
R 4  is aryl;
   
           wherein said aryl is optionally substituted with one to three substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —C(O)O—R 12 , —S(O) 2 —R 12 , —N(R 12 )C(O)—R 12 , —N(R 12 )S(O) 2 R 12 , —C(O)N(R 13 )(R 14 ), —N(R 13 )(R 14 ), C 1-9  alkyl, heterocyclyl, aryl, and heteroaryl;
           wherein said C 1-9  alkyl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, —O—R 12 , —N(R 13 )(R 14 ), C 1-9  alkyl, and heterocyclyl;
 
R 5  is —CN, halo, —O—R 7 , —C(O)R 7 , —N(R 8 )C(O)(R 7 ), —C(O)N(R 8 )(R 9 ), —S(O) 2 R 7 , C 1-9  alkyl, C 2-6  alkynyl, C 3-15  cycloalkyl, aryl, or heteroaryl;
   
           wherein said C 1-9  alkyl, aryl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, —O—R 12 , and C 1-9  alkyl;
 
each R 7  is independently hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl;
   wherein said C 1-9  alkyl, or heterocyclyl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, —O—R 12 , —N(R 13 )(R 14 ), C 1-9  alkyl, aryl, and heteroaryl;
 
each R 12  is independently hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl;
   wherein said C 1-9  alkyl, or heterocyclyl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, —O(C 1-9  alkyl), —N(C 1-9  alkyl) 2 , C 1-9  alkyl, aryl, and heteroaryl; and
 
each R 13  and R 14  are independently hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl;
   wherein said C 1-9  alkyl, or heterocyclyl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, —O(C 1-9  alkyl), —N(C 1-9  alkyl) 2 , C 1-9  alkyl, aryl, and heteroaryl;
 
or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof.
       

     In certain embodiments, Z 3  is hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl;
         wherein said C 1-9  alkyl, C 3-15  cycloalkyl, aryl, or heterocyclyl may be optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —OC(O)—R 12 , —C(O)O—R 12 , —C(O)—N(R 13 )(R 14 ), —N(R 13 )(R 14 ), —N(R 13 ) 2 (R 14 ) + , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl;
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, —O(C 1-9  alkyl), —C(O)—N(C 1-9  alkyl) 2 , C 1-9  alkyl, and heterocyclyl;
 
R 1  is hydrogen, —O—R 7 , —N(R 8 )(R 9 ), —C(O)—R 7 , —S(O) 2 —R 7 , C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl;
   
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl may be optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —C(O)O—R 12 , —N(R 13 )(R 14 ), —N(R 12 )C(O)O—R 12 , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, and heteroaryl;
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, aryl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —N(R 13 )(R 14 ), C 1-9  alkyl, C 3-15  cycloalkyl, and aryl;
 
R 4  is aryl;
   
           wherein said aryl is optionally substituted with one to three substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —C(O)O—R 12 , —S(O) 2 —R 12 , —N(R 12 )C(O)—R 12 , —N(R 12 )S(O) 2 R 12 , —C(O)N(R 13 )(R 14 ), —N(R 13 )(R 14 ), C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, and heteroaryl;
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, —CN, —O—R 12 , —N(R 13 )(R 14 ), C 1-9  alkyl, and heterocyclyl;
 
R 5  is —CN, halo, —O—R 7 , —C(O)R 7 , —N(R 8 )C(O)(R 7 ), —C(O)N(R 8 )(R 9 ), —S(O) 2 R 7 , C 1-9  alkyl, C 2-6  alkynyl, C 3-15  cycloalkyl, aryl, or heteroaryl;
   
           wherein said C 1-9  alkyl, aryl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, —O—R 12 , and C 1-9  alkyl;
 
each R 7  is independently hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl;
   wherein said C 1-9  alkyl, or heterocyclyl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, —O—R 12 , —N(R 13 )(R 14 ), C 1-9  alkyl, aryl, and heteroaryl;
 
each R 12  is independently hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl;
   wherein said C 1-9  alkyl, or heterocyclyl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, —O(C 1-9  alkyl), —N(C 1-9  alkyl) 2 , C 1-9  alkyl, aryl, and heteroaryl; and
 
each R 13  and R 14  are independently hydrogen, C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, or aryl;
   wherein said C 1-9  alkyl, or heterocyclyl may be optionally substituted with one to three substituents independently selected from the group consisting of halo, hydroxy, —O(C 1-9  alkyl), —N(C 1-9  alkyl) 2 , C 1-9  alkyl, aryl, and heteroaryl;
 
or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof.
       

     In certain embodiments, R 1  is C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl; and said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl may be optionally substituted with one to four substituents independently selected the group consisting of halo, —CN, —O—R 12 , —C(O)—R 12 , —C(O)O—R 12 , C 1-9  alkyl, and aryl. In certain embodiments, R 1  is C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl; and said C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, or heteroaryl may be optionally substituted with one to four substituents independently selected the group consisting of halo, —CN, —O—R 12 , C 1-9  alkyl, and aryl. 
     In certain embodiments, R 1  is C 1-9  alkyl, optionally substituted with one to four substituents independently selected the group consisting of halo, —CN, —O—R 12 , —C(O)O—R 12 , C 1-9  alkyl, and aryl. In certain embodiments, R 1  is C 1-9  alkyl, optionally substituted with one to three substituents independently selected the group consisting of halo, —CN, —O—R 12 , C 1-9  alkyl, and aryl. 
     In certain embodiments, R 1  is C 3-15  cycloalkyl, heterocyclyl, or heteroaryl;
         wherein said C 3-15  cycloalkyl, heterocyclyl, or heteroaryl may be optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —N(R 13 )(R 14 ), —NH—C(O)O—R 12 , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, and heteroaryl; and
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, aryl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —N(R 13 )(R 14 ), C 1-9  alkyl, C 3-15  cycloalkyl, and aryl.   
               

     In certain embodiments, R 1  is C 3-15  cycloalkyl, heterocyclyl or heteroaryl, wherein said C 3-15  cycloalkyl, heterocyclyl or heteroaryl is optionally substituted with one to four substituents independently selected the group consisting of halo, —CN, —O—R 12 , C 1-9  alkyl, and aryl. 
     In certain embodiments, R 1  is aryl;
         wherein said aryl may be optionally substituted with one to four substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , —N(R 13 )(R 14 ), —NH—C(O)O—R 12 , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, and heteroaryl; and
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, aryl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —N(R 13 )(R 14 ), C 1-9  alkyl, C 3-15  cycloalkyl, and aryl.   
               

     In certain embodiments, R 1  is aryl;
         wherein said aryl may be optionally substituted with one to three substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —N(R 13 )(R 14 ), —NH—C(O)O—R 12 , —S(O) 2 —R 12 , —Si(R 12 ) 3 , C 1-9  alkyl, C 3-15  cycloalkyl, heterocyclyl, aryl, and heteroaryl; and
           wherein said C 1-9  alkyl, C 3-15  cycloalkyl, aryl, or heteroaryl may be optionally substituted with one to three substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —N(R 13 )(R 14 ), C 1-9  alkyl, C 3-15  cycloalkyl, and aryl.   
               

     In certain embodiments, R 1  is aryl, optionally substituted with one to four substituents independently selected the group consisting of halo, —CN, —O—R 12 , —C(O)—R 12 , C 1-9  alkyl, and aryl. In certain embodiments, R 1  is aryl, optionally substituted with one to three substituents independently selected the group consisting of halo, —CN, —O—R 12 , C 1-9  alkyl, and aryl. 
     In one embodiment, R 1  is ((1R,2R)-2-(hydroxymethyl)cyclohexyl, ((1R,2S)-2-(tert-butoxycarbonylamino)cyclohex-1-yl)amino, ((1S,2R)-2-(tert-butoxycarbonylamino)cyclohex-1-yl)amino, ((1S,2S)-2-(hydroxymethyl)cyclohexyl, (1-(difluoromethyl)cyclobutyl)methyl, (1-(difluoromethyl)cyclopropyl)methyl, (1-(trifluoromethyl)cyclopropyl)methyl, (1-cyclopropylcyclobutyl)methyl, (1-ethylcyclobutyl)methyl, (1-methyl-H-pyrazol-3-yl)methyl, (1-methyl-1H-pyrazol-4-yl)methyl, (1-methyl-1H-pyrazol-5-yl)ethyl, (1-methyl-1H-pyrazol-5-yl)methyl, (1-methylcyclobutyl)methyl, (1-methylcyclopropyl)methyl, (1R,2R)-2-(trifluoromethyl)cyclopropyl, (1R,2R)-2-ethylcyclopropyl, (1R,2S)-2-aminocyclohexyl, (1R,3R)-3-hydroxycyclohexyl, (1R,3R,6S,8S)-tricyclo[4.3.1.13,8]undecan-3-yl, (1R,3S)-3-hydroxycyclohexyl, (1r,4S)-4-hydroxycyclohexyl, (1R,5S)-3-oxabicyclo[3.1.0]hexan-6-yl, (1R,5S)-bicyclo[3.1.0]hexan-6-yl, (1R,5S)-bicyclo[3.3.1]nonan-3-yl, (1R,5S,6s)-bicyclo[3.1.0]hexan-6-yl, (1S,2R)-2-aminocyclohexyl, (1S,2S)-2-hydroxycyclohexyl, (1S,3R)-3-hydroxycyclohexyl, (1S,3S)-3-hydroxycyclohexyl, (1S,3S,5S,7S)-adamantan-2-yl, (1s,4s)-bicyclo[2.2.2]octan-2-yl, (2-(methylsulfonyl)-1-phenylethyl, (2-(trimethylsilyl)ethyl, (3-(trifluoromethyl)phenyl, (3,3-difluoro-1-methylcyclobutyl)methyl, (3-chloro-4-(pyridin-2-ylmethoxy)phenyl, (3-methyloxetan-3-yl)methyl, (3R,4R)-1-ethyl-3-hydroxypiperidin-4-yl, (3R,4R)-3-hydroxypiperidin-4-yl, (3R,5R,7R)-adamantan-1-yl, (4-((dimethylamino)methyl)phenyl, (4-fluorophenyl)methyl, (4-methyltetrahydro-2H-pyran-4-yl)methyl, (R)-((1R,2R)-2-cyanocyclopropyl)(phenyl)methyl, (R)-((1S,2S)-2-cyanocyclopropyl)(phenyl)methyl, (R)-1-(2-fluorophenyl)ethyl, (R)-1-(3-fluorophenyl)ethyl, (R)-1-(3-fluorophenyl)propyl, (R)-1-(4-fluorophenyl)ethyl, (R)-1-(m-tolyl)propyl, (R)-1-(o-tolyl)ethyl, (R)-1-(o-tolyl)propyl, (R)-1-(p-tolyl)propyl, (R)-1-(tetrahydro-2H-pyran-4-yl)ethyl, (R)-1,2,3,4-tetrahydronaphthalen-1-yl, (R)-1-cyano-3,3-dimethylbutan-2-yl, (R)-1-cyclohexylethyl, (R)-1-hydroxy-3,3-dimethylbutan-2-yl, (R)-1-methoxypropan-2-yl, (R)-1-phenyl-(piperidin-1-yl)propyl, (R)-1-phenyl-3-(pyrrolidin-1-yl)propyl, (R)-1-phenylbutyl, (R)-1-phenylethyl, (R)-1-phenylpropyl, (R)-2-(methylsulfonyl)-1-phenylethyl, (R)-2,2,2-trifluoro-1-phenylethyl, (R)-2,2-dimethylcyclohexyl, (R)-2,3-dihydro-1H-inden-1-yl, (R)-2-cyano-1-phenylethyl, (R)-2-cyano-1-phenylethyl, (R)-2-methyl-1-phenylpropyl, (R)-2-phenylpropyl, (R)-3,3-dimethylbutan-2-yl, (R)-3,3-dimethyltetrahydro-2H-pyran-4-yl, (R)-3-cyano-1-phenylpropyl, (R)-3-fluoro-1-phenylpropyl, (R)-3-hydroxy-1-phenylpropyl, (R)-3-morpholino-1-phenylpropyl, (R)-chroman-4-yl, (R)-cyclopropyl(phenyl)methyl, (R)-sec-butyl, (R)-tetrahydro-2H-pyran-3-yl, (S)-((1R,2R)-2-cyanocyclopropyl)(phenyl)methyl, (S)-((1S,2S)-2-cyanocyclopropyl)(phenyl)methyl, (S)-1-(tetrahydro-2H-pyran-4-yl)ethyl, (S)-1,2,3,4-tetrahydronaphthalen-1-yl, (S)-1-hydroxy-3,3-dimethylbutan-2-yl, (S)-1-methoxypropan-2-yl, (S)-1-phenylethyl, (S)-2-(methylsulfonyl)-1-phenylethyl, (S)-2,2,2-trifluoro-1-phenylethyl, (S)-2,2-dimethylcyclohexyl, (S)-2,3-dihydro-1H-inden-1-yl, (S)-2-cyano-1-phenylethyl, (S)-2-hydroxy-1-phenylethyl, (S)-2-methoxy-1-phenylethyl, (S)-2-phenylpropyl, (S)-3,3-dimethylbutan-2-yl, (S)-3,3-dimethyltetrahydro-2H-pyran-4-yl, (S)-3-cyano-1-phenylpropyl, (S)-3-hydroxy-1-phenylpropyl, (S)-chroman-4-yl, (S)-sec-butyl, (S)-tetrahydro-2H-pyran-3-yl, (tetrahydro-2H-pyran-2-yl)methyl, (tetrahydro-2H-pyran-3-yl)methyl, (tetrahydrofuran-3-yl)methyl, (trimethylsilyl)methyl, [1,1′-bi(cyclopropan)]-1-yl, 1-((3R,4R)-3-hydroxy-1-(oxetan-3-yl)piperidin-4-yl, 1-(2,2,2-trifluoroethyl)-1-pyrazol-3-yl, 1-(5,6-difluoropyridin-3-yl)propyl, 1-(pyridin-2-yl)ethyl, 1-(pyridin-3-yl)ethyl, 1-(tert-butyl)cyclopropyl, 1-(tert-butyl)piperidin-4-yl, 1-(tetrahydro-2H-pyran-4-yl)propyl, 1,1-dioxidothietan-3-yl, 1-benzyl-1H-indazol-5-yl, 1-cyanocyclopropyl, 1-ethylcyclobutyl, 1-ethylcyclopropyl, 1-hydroxy-2-methylpropan-2-yl, 1-methyl-1H-pyrazol-4-yl, 1-methyl-6-oxo-1,6-dihydropyridin-3-yl, 1-methylcyclobutyl, (1-methylcyclobutyl)methyl, 1-methylcycloheptyl, 1-methylcyclohexyl, 1-methylcyclopropyl, 1-methylcyclopropyl, 1-methylpiperidin-4-yl, 1-phenylbutan-2-yl, 1-phenylcyclopropyl, 2-(1H-imidazol-2-yl)ethyl, 2-(1-methyl-1H-imidazol-2-yl)ethyl, 2-(1-methyl-1H-pyrazol-3-yl)ethyl, 2-(pyridin-2-yl)ethyl, 2-(pyridin-3-yl)ethyl, 2-(thiazol-2-yl)ethyl, 2-(trifluoromethoxy)phenyl, 2,2,2-trichloroethyl, 2,2,2-trifluoroethyl, 2,2,3-trimethylbutyl, 2,2-difluoropropyl 2,2-dimethyl-1-phenylpropyl, 2,2-dimethylbutyl, 2,2-dimethylcyclopentyl, 2,2-dimethylcyclopropyl, 2,2-dimethylpropyl-1,1-d2,2,3,4-trifluorophenyl, 2,3-dichloro-4-fluorophenyl, 2,3-dichlorophenyl, 2,3-difluorobenzyl, 2,3-dimethylbutan-2-yl, 2,4,5-trifluorophenyl, 2,4,6-trifluorophenyl, 2,4-dichloro-5-methoxyphenyl, 2,4-difluorophenyl, 2,5-dichlorophenyl, 2,6-difluorophenyl, 2,6-dimethylcyclohexyl, 2,6-dimethyltetrahydro-2H-pyran-4-yl, 2-chlorobenzyl, 2-chlorothiophen-3-yl, 2-cyano-1-phenylethyl, 2-cyano-2-methylpropyl, 2-cyano-4-fluorophenyl, 2-cyanoethyl, 2-cyclopropylethyl, 2-fluoro-2-methylpropyl, 2-fluorobenzyl, 2-fluorophenyl, 2-fluoropyridin-3-yl, 2-hydroxy-2-methylpropyl, 2-methoxyl-2-methylpropyl, 2-methoxybenzyl, 2-methoxyethyl, 2-methoxyphenyl, 2-methoxypyridin-3-yl, 2-methyl-2-phenylpropyl, 2-methyl benzyl, 2-methylcyclohexyl, 2-morpholino-1-phenyl ethyl, 2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl, 3-(2H-1,2,3-triazol-2-yl)phenyl, 3-(difluoromethyl)phenyl, 3-(dimethylamino)propyl, 3,3,3-trifluoro-1-phenylpropyl, 3,3-difluoro-1-methylcyclobutyl, 3,3-difluorocyclobutyl, 3,3-dimethylbutyl, 3,3-dimethylcyclobutyl, 3,3-dimethyltetrahydro-2H-pyran-4-yl, 3,4-dichloro-2-fluorophenyl, 3,4-dichlorophenyl, 3,4-difluorophenyl, 3,5-dichlorophenyl, 3,5-difluorophenyl, 3-bromo-4-fluorophenyl, 3-bromophenyl, 3-chloro-2,2-dimethylpropyl, 3-chloro-2,4-difluorophenyl, 3-chloro-2,6-difluorophenyl, 3-chloro-2-cyclopropoxyphenyl, 3-chloro-2-fluorophenyl, 3-chloro-2-methoxyphenyl, 3-chloro-2-methylphenyl, 3-chloro-4,5-difluorophenyl, 3-chloro-4-cyanophenyl, 3-chloro-4-ethoxyphenyl, 3-chloro-4-fluorophenyl, 3-chloro-4-hydroxyphenyl, 3-chloro-5-fluorophenyl, 3-chlorophenyl, 3-cyano-1-phenylpropyl, 3-cyano-2,2-dimethylpropyl, 3-cyano-2,4-difluorophenyl, 3-cyanophenyl, 3-fluorophenyl, 3-hydroxy-2,2-dimethylpropyl, 3-hydroxycyclohexyl, 3-methoxy-2,2-dimethylpropyl, 3-methylbenzyl), 3-methyloxetan-3-yl, 3-phenylpropyl, 4-(benzoxy)-3-chlorophenyl, 4-(trifluoromethoxy)phenyl, 4,5-dichloro-2-fluorophenyl, 4-chloro-3-fluorophenyl, 4-chlorophenyl, 4-chlorothiophen-3-yl, 4-fluoro-3-(methylsulfonyl)phenyl, 4-fluoro-3-(trifluoromethoxy)phenyl, 4-fluoro-3-(trifluoromethyl)phenyl, 4-fluorophenyl, 4-hydroxybutan-2-yl, 4-methylbenzyl, 5,6-difluoropyridin-3-yl, 5-chloro-2,4-difluorophenyl, 5-chloro-2-fluorophenyl, 5-chloro-6-fluoropyridin-3-yl, 5-chloropyridin-3-yl, 5-chlorothiophen-3-yl, 5-fluoropyridin-3-yl, 6-(trifluoromethyl)pyridin-3-yl, 6-chloro-5-fluoropyridin-3-yl, 6-fluoro-5-methylpyridin-3-yl, 6-fluoropyridin-3-yl, 6-methoxypyridin-3-yl, azepan-1-yl, benzyl, bicyclo[1.1.1]pentan-1-yl, bicyclo[2.2.1]heptan-2-yl, bicyclo[3.1.0]hexan-2-yl, bicyclo[3.1.0]hexan-6-yl, bicyclo[4.1.0]heptan-2-yl, cyclobutyl, cyclobutylmethyl, cycloheptyl, cyclohexyl, cyclopentyl, cyclopropyl, cyclopropylmethyl, H, isobutyl, isopentyl, isopropyl, morpholino, m-tolyl, N-cyclohexylamino, neopentyl, N-ethyl-N-phenylamino, oxetan-3-yl, oxetan-3-ylmethyl, phenethyl, phenyl, phenylcarbonyl, phenylsulfonyl, piperidin-1-yl, p-tolyl, pyridin-3-yl, pyrrolidin-1-yl, quinuclidin-3-yl, spiro[2.5]octan-1-yl, tert-butoxy, tert-butyl, tert-butylamino, tert-butylcarbonyl, tert-pentyl, tetrahydro-2H-pyran-4-yl, tetrahydro-2H-pyran-4-yl)methyl, thiazol-2-ylmethyl, thiazol-4-ylmethyl, thiazol-5-ylmethyl, thiophen-2-ylmethyl, or thiophen-3-ylmethyl. 
     In one embodiment, R 1  is (1R,2R)-2-(hydroxymethyl)cyclohexyl, (1R,2S)-2-(tert-butoxycarbonylamino)cyclohex-1-yl)amino, (1S,2R)-2-(tert-butoxycarbonylamino)cyclohex-1-yl)amino, (1S,2S)-2-(hydroxymethyl)cyclohexyl, (1-(difluoromethyl)cyclobutyl)methyl, (1-(difluoromethyl)cyclopropyl)methyl, (1-(trifluoromethyl)cyclopropyl)methyl, (1-cyclopropylcyclobutyl)methyl, (1-ethylcyclobutyl)methyl, (1-methyl-1H-pyrazol-3-yl)methyl, (1-methyl-1H-pyrazol-4-yl)methyl, (1-methyl-1H-pyrazol-5-yl)ethyl, (1-methyl-1H-pyrazol-5-yl)methyl, (1-methylcyclobutyl)methyl, (1-methylcyclopropyl)methyl, (1R,2R)-2-(trifluoromethyl)cyclopropyl, (1R,2R)-2-ethylcyclopropyl, (1R,2S)-2-aminocyclohexyl, (1R,3R)-3-hydroxycyclohexyl, (1R,3R,6S,8S)-tricyclo[4.3.1.13,8]undecan-3-yl, (1R,3S)-3-hydroxycyclohexyl, (1r,4S)-4-hydroxycyclohexyl, (1R,5S)-3-oxabicyclo[3.1.0]hexan-6-yl, (1R,5S)-bicyclo[3.1.0]hexan-6-yl, (1R,5S)-bicyclo[3.3.1]nonan-3-yl, (1R,5S,6s)-bicyclo[3.1.0]hexan-6-yl, (1S,2R)-2-aminocyclohexyl, (1S,2S)-2-hydroxycyclohexyl, (1S,3R)-3-hydroxycyclohexyl, (1S,3S)-3-hydroxycyclohexyl, (1S,3S,5S,7S)-adamantan-2-yl, (1s, 4s)-bicyclo[2.2.2]octan-2-yl, (2-(methylsulfonyl)-1-phenylethyl, (2-(trimethylsilyl)ethyl, (3-(trifluoromethyl)phenyl, (3,3-difluoro-1-methylcyclobutyl)methyl, (3-chloro-4-(pyridin-2-ylmethoxy)phenyl, (3-methyloxetan-3-yl)methyl, (3R,4R)-1-ethyl-3-hydroxypiperidin-4-yl, (3R,4R)-3-hydroxypiperidin-4-yl, (3R,5R,7R)-adamantan-1-yl, (4-((dimethylamino)methyl)phenyl, (4-fluorophenyl)methyl, (4-methyltetrahydro-2H-pyran-4-yl)methyl, (R)-(1R,2R)-2-cyanocyclopropyl)(phenyl)methyl, (R)-(1S,2S)-2-cyanocyclopropyl)(phenyl)methyl, (R)-1-(2-fluorophenyl)ethyl, (R)-1-(3-fluorophenyl)ethyl, (R)-1-(3-fluorophenyl)propyl, (R)-1-(4-fluorophenyl)ethyl, (R)-1-(m-tolyl)propyl, (R)-1-(o-tolyl)ethyl, (R)-1-(o-(tolyl)propyl, (R)-1-(p-tolyl)propyl, (R)-1-(tetrahydro-2H-pyran-4-yl)ethyl, (R)-1,2,3,4-tetrahydronaphthalen-1-yl, (R)-1-cyano-3,3-dimethylbutan-2-yl, (R)-1-cyclohexylethyl, (R)-1-hydroxy-3,3-dimethylbutan-2-yl, (R)-1-methoxypropan-2-yl, (R)-1-phenyl-3-(piperidin-1-yl)propyl, (R)-1-phenyl-3-(pyrrolidin-1-yl)propyl, (R)-1-phenylbutyl, (R)-1-phenylethyl, (R)-1-phenylpropyl, (R)-2-(methylsulfonyl)-1-phenylethyl, (R)-2,2,2-trifluoro-1-phenylethyl, (R)-2,2-dimethylcyclohexyl, (R)-2,3-dihydro-1H-inden-1-yl, (R)-2-cyano-1-phenylethyl, (R)-2-cyano-1-phenylethyl, (R)-2-methyl-1-phenylpropyl, (R)-2-phenylpropyl, (R)-3,3-dimethylbutan-2-yl, (R)-3,3-dimethyltetrahydro-2H-pyran-4-yl, (R)-3-(methylsulfonyl)-1-phenylpropyl, (R)-3-carboxy-1-phenylpropyl, (R)-3-cyano-1-phenylpropyl, (R)-3-fluoro-1-phenylpropyl, (R)-3-hydroxy-1-phenylpropyl, (R)-3-methoxy-1-phenylpropyl, (R)-3-morpholino-1-phenylpropyl, (R)-chroman-4-yl, (R)-cyclopropyl, (phenyl)methyl, (R)-sec-butyl, (R)-tetrahydro-2H-pyran-3-yl, (S)-(1R,2R)-2-cyanocyclopropyl)(phenyl)methyl, (S)-(1S,2S)-2-cyanocyclopropyl)(phenyl)methyl, (S)-1-(tetrahydro-2H-pyran-4-yl)ethyl, (S)-1,2,3,4-tetrahydronaphthalen-1-yl, (S)-1-hydroxy-3,3-dimethylbutan-2-yl, (S)-1-methoxypropan-2-yl, (S)-1-phenylethyl, (S)-2-(methylsulfonyl)-1H-phenylethyl, (S)-2,2,2-trifluoro-1-phenylethyl, (S)-2,2-difluoro-3-hydroxy-1-phenylpropyl, (S)-2,2-dimethylcyclohexyl, (S)-2,3-dihydro-1H-inden-1-yl, (S)-2-cyano-1-phenylethyl, (S)-2-hydroxy-1-phenylethyl, (S)-2-methoxy-1-phenylethyl, (S)-2-phenylpropyl, (S)-3,3-dimethylbutan-2-yl, (S)-3,3-dimethyltetrahydro-2H-pyran-4-yl, (S)-3-cyano-1-phenylpropyl, (S)-3-hydroxy-1-phenylpropyl, (S)-chroman-4-yl, (S)-sec-butyl, (S)-tetrahydro-2H-pyran-3-yl, (tetrahydro-2H-pyran-2-yl)methyl, (tetrahydro-2H-pyran-3-yl)methyl, (tetrahydrofuran-3-yl)methyl, (trimethylsilyl)methyl, [1,1-bi(cyclopropan)]-1-yl, 1-((3R,4R)-3-hydroxy-1-(oxetan-3-yl)piperidin-4-yl, 1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl, 1-(5,6-difluoropyridin-3-yl)propyl, 1-(difluoromethyl)cyclopropyl, 1-(pyridin-2-yl)ethyl, 1-(pyridin-3-yl)ethyl, 1-(tert-butyl)cyclopropyl, 1-(tert-butyl)piperidin-4-yl, 1-(tetrahydro-2H-pyran-4-yl)propyl, 1,1-dioxidothietan-3-yl, 1-benzyl-1H-indazol-5-yl, 1-cyanocyclopropyl, 1-ethylcyclobutyl, 1-ethylcyclopropyl, 1-hydroxy-2-methylpropan-2-yl, 1-methyl-1H-pyrazol-4-yl, 1-methyl-6-oxo-1,6-dihydropyridin-3-yl, 1-methyl cyclobutyl, (1-methylcyclobutyl)methyl, 1-methylcycloheptyl, 1-methylcyclohexyl, 1-methylcyclopropyl, 1-methylcyclopropyl, 1-methylpiperidin-4-yl, 1-phenylbutan-2-yl, 1-phenylcyclopropyl, 2-(1-imidazol-2-yl)ethyl, 2-(1-methyl-1H-imidazol-2-yl)ethyl, 2-(1-methyl-1H-pyrazol-3-yl)ethyl, 2-(pyridin-2-yl)ethyl, 2-(pyridin-3-yl)ethyl, 2-(thiazol-2-yl)ethyl, 2-(trifluoromethoxy)phenyl, 2,2,2-trichloroethyl, 2,2,2-trifluoroethyl, 2,2,3-trimethylbutyl, 2,2-difluoropropyl, 2,2-dimethyl-1-phenylpropyl, 2,2-dimethylbutyl, 2,2-dimethylcyclopentyl, 2,2-dimethylcyclopropyl, 2,2-dimethylpropyl-1,1-d2, 2,3,4-trifluorophenyl, 2,3-dichloro-4-fluorophenyl, 2,3-dichlorophenyl, 2,3-difluorobenzyl, 2,3-dimethylbutan-2-yl, 2,4,5-trifluorophenyl, 2,4,6-trifluorophenyl, 2,4-dichloro-5-methoxyphenyl, 2,4-difluorophenyl, 2,5-dichlorophenyl, 2,6-difluorophenyl, 2,6-dimethylcyclohexyl, 2,6-dimethyltetrahydro-2H-pyran-4-yl, 2-acetyl-3-chlorophenyl, 2-chlorobenzyl, 2-chlorothiophen-3-yl, 2-cyano-1-phenylethyl, 2-cyano-2-methylpropyl, 2-cyano-4-fluorophenyl, 2-cyanoethyl, 2-cyclopropylethyl, 2-fluoro-2-methylpropyl, 2-fluorobenzyl, 2-fluorophenyl, 2-fluoropyridin-3-yl, 2-hydroxy-2-methylpropyl, 2-methoxyl-2-methylpropyl, 2-methoxybenzyl, 2-methoxyethyl, 2-methoxyphenyl, 2-methoxypyridin-3-yl, 2-methyl-2-phenylpropyl, 2-methylbenzyl, 2-methylcyclohexyl, 2-methyl-2-(pyridin-2-yl)propyl, 2-morpholino-1-phenylethyl, 2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl, 3-(2H-1,2,3-triazol-2-yl)phenyl, 3-(difluoromethyl)phenyl, 3-(dimethylamino)propyl, 3,3,3-trifluoro-1-phenylpropyl, 3,3-difluoro-1-methylcyclobutyl, 3,3-difluorocyclobutyl, 3,3-dimethylbutyl, 3,3-dimethyl cyclobutyl, 3,3-dimethyltetrahydro-2H-pyran-4-yl, 3,4-dichloro-2-fluorophenyl, 3,4-dichlorophenyl, 3,4-difluorophenyl, 3,5-dichlorophenyl, 3,5-difluorophenyl, 3-chloro-4-fluorophenyl, 3-bromophenyl, 3-chloro-2,2-dimethylpropyl, 3-chloro-2,4-difluorophenyl, 3-chloro-2,6-difluorophenyl, 3-chloro-2-cyclopropoxyphenyl, 3-chloro-2-fluorophenyl, 3-chloro-2-methoxyphenyl, 3-chloro-2-methylphenyl, 3-chloro-4,5-difluorophenyl, 3-chloro-2-cyanophenyl, 3-chloro-4-cyanophenyl, 3-chloro-4-ethoxyphenyl, 3-chloro-4-fluorophenyl, 3-chloro-4-hydroxyphenyl, 3-chloro-5-fluorophenyl, 3-chlorophenyl, 3-chloro-2-(methylsulfonyl)phenyl, 3-chloro-2-(trifluoromethoxy)phenyl, 3-cyano-1-phenylpropyl, 3-cyano-2,2-dimethylpropyl, 3-cyano-2,4-difluorophenyl, 3-cyanophenyl, 3-fluorophenyl, 3-hydroxy-2,2-dimethyl propyl, 3-hydroxycyclohexyl, 3-methoxy-2,2-dimethylpropyl, 3-methylbenzyl), 3-methyloxetan-3-yl, 3-phenylpropyl, 4-(benzyloxy)-3-chlorophenyl, 4-(trifluoromethoxy)phenyl, 4,5-dichloro-2-fluorophenyl, 4-chloro-3-fluorophenyl, 4-chlorophenyl, 4-chlorothiophen-3-yl, 4-cyano-1-phenylbutyl, 4-fluoro-3-(methylsulfonyl)phenyl, 4-fluoro-3-(trifluoromethoxy)phenyl, 4-fluoro-3-(trifluoromethyl)phenyl, 4-fluorophenyl, 4-hydroxybutan-2-yl, 4-methylbenzyl, 5,6-difluoropyridin-3-yl, 5-chloro-2,4-difluorophenyl, 5-chloro-2-fluorophenyl, 5-chloro-6-fluoropyridin-3-yl, 5-chloropyridin-3-yl, 5-chlorothiophen-3-yl, 5-fluoropyridin-3-yl, 6-(trifluoromethyl)pyridin-3-yl, 6-chloro-5-fluoropyridin-3-yl, 6-fluoro-5-methylpyridin-3-yl, 6-fluoropyridin-3-yl, 6-methoxypyridin-3-yl, azepan-1-yl, benzyl, bicyclo[1.1.1]pentan-1-yl, bicyclo[1.1.1]pentan-1-ylmethyl, bicyclo[2.2.1]heptan-2-yl, bicyclo[3.1.0]hexan-2-yl, bicyclo[3.1.0]hexan-6-yl, bicyclo[4.1.0]heptan-2-yl, cyclobutyl, cyclobutylmethyl, cycloheptyl, cyclohexyl, cyclopentyl, cyclopropyl, cyclopropylmethyl, H, isobutyl, isopentyl, isopropyl, morpholino, m-tolyl, naphthalen-1-yl, N-cyclohexylamino, neopentyl, N-ethyl-N-phenylamino, oxetan-3-yl, oxetan-3-ylmethyl, phenethyl, phenyl, phenylcarbonyl, phenylsulfonyl, piperidin-1-yl, p-tolyl, pyri din-3-yl, pyrrolidin-1-yl, quinuclidin-3-yl, spiro[2.5]octan-1-yl, tert-butoxy, tert-butyl, tert-butylamino, tert-butylcarbonyl, tert-pentyl, tetrahydro-2H-pyran-4-yl, tetrahydro-2H-pyran-4-yl)methyl, thiazol-2-ylmethyl, thiazol-4-ylmethyl, thiazol-5-ylmethyl, thiophen-2-ylmethyl, or thiophen-3-ylmethyl. 
     In certain embodiments, R 1  is (R)-1-phenylethyl, (R)-1-phenylpropyl, 3,4-dichloro-2-fluorophenyl, 3-chloro-4-fluorophenyl, 5,6-difluoropyridin-3-yl, or neopentyl. 
     In one embodiment, R 2  is hydrogen. In one embodiment, R 2  is C 1-6  alkyl. In one embodiment, R 2  is methyl. 
     In one embodiment, R 1  and R 2  together with the nitrogen atom to which they are attached form a heterocyclyl or heterocyclyl. In certain embodiments, R 1  and R 2  together with the nitrogen to which they are attached to form a heterocyclyl or heteroaryl, wherein said heterocyclyl may be optionally substituted with one to three C 1-9  alkyl. In certain embodiments, R 1  and R 2  together with the nitrogen atom to which they are attached form an optionally substituted pyrazolyl. In certain embodiments, R 1  and R 2  together with the nitrogen atom to which they are attached form 3,3-dimethylpiperidin-1-yl. 
     In one embodiment, R 3  is heterocyclyl or heteroaryl, wherein each heterocyclyl or heteroaryl is optionally substituted with one or more substituents (i.e., Z 3 ) selected from the group consisting of ((2-hydroxycarbonyl)-2,2-dimethyl)ethyl, ((R)-pyrrolidin-2-yl)methyl, ((S)-1-ethylpyrrolidin-3-yl, (1-(trifluoromethyl)cyclopropyl, (1-ethylazetidin-3-yl)methyl, (1-hydroxycyclopropyl)methyl, (1-methylcyclobutyl)methyl, (1-methylcyclopropyl)methyl, (1R,2S)-2-(trifluoromethyl)cyclopropyl, (1R,5S,6R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl, (1R,5S,6S)-3-azabicyclo[3.1.0]hexan-6-yl, (2R)-1-(dimethylaminocarbonyl)pyrrolidin-2-yl, (3-(pyrrolidin-1-yl)oxetan-3-yl)methyl, (3-fluorooxetan-3-yl)methyl, (3R)-1-(benzyloxycarbonyl)pyrrolidin-3-yl, (3R,4R)-1-ethyl-3-fluoropiperidin-4-yl, (3R,4R)-1-ethyl-3-hydroxypiperidin-4-yl, (3R,4R)-3-fluoropiperidin-4-yl, (3R,4R)-3-hydroxy-1-(oxetan-3-yl)piperidin-4-yl, (3R,4R)-3-hydroxypiperidin-4-yl, (3S)-1-(benzyloxycarbonyl)pyrrolidin-4-yl, (3S,4R)-3-fluoropiperidin-4-yl, (oxetan-3-yl)piperidin-4-yl, (R)-1,1,1-trifluoropropan-2-yl, (R)-1-ethylpyrrolidin-3-yl, (R)-2,2-dimethylpiperidin-4-yl, (R)-pyrrolidin-3-yl, (S)-1-ethylpyrrolidin-3-yl, (S)-1-fluoropropan-2-yl, (S)-pyrrolidin-3-yl, (trimethylsilyl)methyl, 1-(2,2,2-trifluoroethyl, 1-(2,2,2-trifluoroethyl)piperidin-4-yl, 1-(2,2-difluoroethyl)piperidin-4-yl, 1-(2-methoxyethyl)piperidin-4-yl, 1-(3,3-difluorocyclobutyl)piperidin-4-yl, 1-(benzyloxycarbonyl)2,2-dimethylpiperidin-4-yl, 1-(benzyloxycarbonyl)piperidin-4-yl, 1-(dimethylaminocarbonyl)methylpiperidin-4-yl, 1-(methylsulfonyl)piperidin-4-yl, 1-(oxetan-3-yl)piperidin-4-yl, 1-(tert-butyl)piperidin-4-yl, 1-(tert-butyloxycarbonyl)piperidin-4-yl, 1-(trifluoromethyl)cyclopropyl, 1,1-difluoro-2-hydroxyethyl, 1,1-difluoropropan-2-yl, 1,1-dioxidothietan-3-yl, 1-acetylpiperidin-4-yl, 1-cyanocyclopropyl, 1-cyclopropylpiperidin-4-yl, 1-ethyl-2,2-dimethylpiperidin-4-yl, 1-ethyl-5,5-difluoropiperidin-3-yl, 1-ethylazetidin-3-yl, 1-ethylpiperidin-4-yl, 1-isopropylpiperidin-4-yl, 1-methylcyclopropyl, 1-methylpiperidin-4-yl, 2-(2-methoxyethoxy)ethyl, 2-(diethyl(methyl)ammonio)ethyl, 2-(dimethylamino)ethyl, 2-(trifluoromethyl)phenyl, 2,2,2-trifluoroethyl, 2,2,6,6-tetramethylpiperidin-4-yl, 2,2-difluorocyclopropyl, 2,2-difluoroethyl, 2,2-dimethylpiperidin-4-yl, 2,6-difluorobenzyl, 2-aminoethyl, 2-azaspiro[3.3]heptan-6-yl, 2-ethyl-2-azaspiro[3.3]heptan-6-yl, 2-fluoroethyl, 2-hydroxy-2-methylpropyl, 2-hydroxyethyl, 2-methoxyethyl, 2-morpholino-2-oxoethyl, 2-morpholinoethyl, 3-(dimethylamino)propyl, 3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl, 3-(pyrrolidin-1-yl)propyl, 3,3,3-trifluoro-2-hydroxypropyl, 3,3-dimethylpiperidin-4-yl, 3-azabicyclo[3.1.0]hexan-6-yl, 3-ethyl-3-azabicyclo[3.1.0]hexan-6-yl, 3-fluorooxetan-3-yl)methyl, 3-fluoropropyl, 3-hydroxyoxetan-3-yl, 3-hydroxypropyl, 3-methyloxetan-3-yl, 4-fluorophenyl, 5,5-difluoro-1-methylpiperidin-3-yl, 5,5-difluoropiperidin-3-yl, 5-methyl-1H-1,2,3-triazol-4-yl, aminocarbonylmethyl, azetidin-3-yl, benzyl, bicyclo[1.1.1]pentan-1-yl, cyanomethyl, cyclopentyl, cyclopropyl, difluoromethyl, fluoromethyl, hydroxycarbonylmethyl, isopropyl, methyl, neopentyl, oxazol-2-yl, oxetan-2-ylmethyl, oxetan-3-yl, phenyl, piperidin-4-yl, pivalylmethyl, pyridin-2-ylmethyl, pyridin-3-yl, pyridin-4-yl, pyrimidin-2-yl, pyrrolidin-1-yl)ethyl, quinuclidin-3-yl, tert-butyl, and tetrahydro-2H-pyran-4-yl. 
     In one embodiment, R 3  is heterocyclyl or heteroaryl, wherein the heterocyclyl or heteroaryl is optionally substituted with one or more substituents (i.e., Z 3 ) selected from the group consisting of ((2-hydroxycarbonyl)-2,2-dimethyl)ethyl, ((R)-pyrrolidin-2-yl)methyl, (S)-1-ethylpyrrolidin-3-yl, (1-(trifluoromethyl)cyclopropyl, (1-ethylazetidin-3-yl)methyl, (1-hydroxycyclopropyl)methyl, (1-methylcyclobutyl)methyl, (1-methylcyclopropyl)methyl, (1R,2S)-2-(trifluoromethyl)cyclopropyl, (1R,5S,6R)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl, (1R,5S,6S)-3-azabicyclo[3.1.0]hexan-6-yl, (1R,5S,6s)-3-cyclopropyl-3-azabicyclo[3.1.0]hexan-6-yl, (2R)-1-(dimethylaminocarbonyl)pyrrolidin-2-yl, (3-(pyrrolidin-1-yl)oxetan-3-yl)methyl, (3-fluorooxetan-3-yl)methyl, (3R)-1-(benzyloxycarbonyl)pyrrolidin-3-yl, (3R,4R)-1-ethyl-3-fluoropiperidin-4-yl, (3R,4R)-1-ethyl-3-hydroxypiperidin-4-yl, (3R,4R)-3-fluoropiperidin-4-yl, (3R,4R)-3-hydroxy-1-(oxetan-3-yl)piperidin-4-yl, (3R,4R)-3-hydroxypiperidin-4-yl, (3S)-1-(benzyloxycarbonyl)pyrrolidin-4-yl, (3S,4R)-3-fluoropiperidin-4-yl, (oxetan-3-yl)piperidin-4-yl, (R)-1,1,1-trifluoropropan-2-yl, (R)-1-ethylpyrrolidin-3-yl, (R)-2,2-dimethylpiperidin-4-yl, (R)-pyrrolidin-3-yl, (S)-1-ethylpyrrolidin-3-yl, (S)-1-fluoropropan-2-yl, (S)-pyrrolidin-3-yl, (trimethylsilyl)methyl, [1,1′-bi(cyclopropan)]-1-yl, 1-(1-(trifluoromethyl)cyclopropyl)-1H-1,2,3-triazol-4-yl)methyl, 1-(1-methylcyclopropyl)-1H-1,2,3-triazol-4-yl)methyl, 1-(2,2,2-trifluoroethyl, 1-(2,2,2-trifluoroethyl)piperidin-4-yl, 1-(2,2-difluoroethyl)piperidin-4-yl, 1-(2-methoxyethyl)piperidin-4-yl, 1-(3-(hydroxymethyl)oxetan-3-yl, 1-(3,3-difluorocyclobutyl)piperidin-4-yl, 1-(benzyloxycarbonyl)2,2-dimethylpiperidin-4-yl, 1-(benzyloxycarbonyl)piperidin-4-yl, 1-(difluoromethyl)cyclopropyl, 1-(dimethylaminocarbonyl)methylpiperidin-4-yl, 1-(fluoromethyl)cyclopropyl, 1-(hydroxymethyl)cyclopropyl, 1-(methylsulfonyl)piperidin-4-yl, 1-(oxetan-3-yl)piperidin-4-yl, 1-(pyrazin-2-yl)cyclopropyl, 1-(pyridazin-3-yl)cyclopropyl, 1-(pyridin-2-yl)cyclopropyl, 1-(pyridin-3-yl)cyclopropyl, 1-(pyridin-4-yl)cyclopropyl, quinuclidin-4-yl, 1-(tert-butyl)aziridin-2-yl)ethyl, 1-(tert-butyl)piperidin-4-yl, 1-(tert-butyloxycarbonyl)piperidin-4-yl, 1-(trifluoromethyl)cyclobutyl, 1-(trifluoromethyl)cyclopropyl, 1,1-difluoro-2-hydroxyethyl, 1,1-difluoropropan-2-yl, 1,1-dioxidothietan-3-yl, 1-acetylpiperidin-4-yl, 1-carbamoylcyclobut-1-yl, 1-carbamoylcyclopent-1-yl, 1-cyanocyclobutyl, 1-cyanocyclopropyl, 1-cyclopropyl-1H-1,2,3-triazol-4-yl, 1-cyclopropylpiperidin-4-yl, 1-ethyl-2,2-dimethylpiperidin-4-yl, 1-ethyl-5,5-difluoropiperidin-3-yl, 1-ethylazetidin-3-yl, 1-ethylpiperidin-4-yl, 1-isopropylpiperidin-4-yl, 1-methylcyclopropyl, 1-methylpiperidin-4-yl, 2-(2-methoxyethoxy)ethyl, 2-(diethyl(methyl)ammonio)ethyl, 2-(dimethylamino)ethyl, 2-(trifluoromethyl)phenyl, 2,2,2-trifluoroethyl, 2,2,6,6-tetramethylpiperidin-4-yl, 2,2-difluorocyclopropyl, 2,2-difluoroethyl, 2,2-dimethylpiperidin-4-yl, 2,6-difluorobenzyl, 2-amino-1,1-difluoro-2-oxoeth-1-yl, 2-amino-1,1-dimethyl-2-oxoethyl, 2-amino-2-oxoeth-1-yl, 2-aminoethyl, 2-azaspiro[3.3]heptan-6-yl, 2-ethyl-2-azaspiro[3.3]heptan-6-yl, 2-fluoroethyl, 2-hydroxy-2-methylpropyl, 2-hydroxyethyl, 2-methoxyethyl, 2-morpholino-2-oxoethyl, 2-morpholinoethyl, 3-(dimethylamino)propyl, 3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl, 3-(pyrrolidin-1-yl)propyl, 3-(tert-butylamino)-2-hydroxypropyl, 3,3,3-trifluoro-2-hydroxypropyl, 3,3-dimethylpiperidin-4-yl, 3-azabicyclo[3.1.0]hexan-6-yl, 3-carbamoyltetrahydrofuran-3-yl, 3-ethyl-3-azabicyclo[3.1.0]hexan-6-yl, 3-fluorooxetan-3-yl)methyl, 3-fluoropropyl, 3-hydroxyoxetan-3-yl, 3-hydroxypropyl, 3-methyloxetan-3-yl, 4-carbamoyltetrahydropyran-4-yl, 4-fluorophenyl, 5,5-difluoro-1-methylpiperidin-3-yl, 5,5-difluoropiperidin-3-yl, 5-methyl-1H-1,2,3-triazol-4-yl, aminocarbonylmethyl, azetidin-3-yl, benzyl, bicyclo[1.1.1]pentan-1-yl, cyanomethyl, cyclopentyl, cyclopropyl, difluoromethyl, fluoromethyl, hydroxycarbonylmethyl isopropyl, methyl, neopentyl, oxazol-2-yl, oxetan-2-ylmethyl, oxetan-3-yl, phenyl, piperidin-4-yl, pivalylmethyl, pyridin-2-ylmethyl, pyridin-3-yl, pyridin-4-yl, pyrimidin-2-yl, pyrrolidin-1-yl)ethyl, quinuclidin-3-yl, tert-butyl, and tetrahydro-2H-pyran-4-yl. 
     In one embodiment, R 3  is triazolyl, pyrazolyl, isoxazolyl, isoxazolyl, oxazolyl, pyrazinyl, pyridinyl, pyrimidinyl, imidazolyl, thiadiazolyl, tetrazolyl, or oxadiazolyl, wherein each is optionally substituted by one or more Z 3  groups as described herein. In one embodiment, R 3  is optionally substituted triazolyl (e.g., 1H-1,2,3-triazolyl). 
     In certain embodiments, R 3  is triazolyl substituted with one or more substituents selected from the group consisting of 1-(benzyloxycarbonyl)piperidin-4-yl, 1-(tert-butyl)piperidin-4-yl, 1-ethylpiperidin-4-yl, cyclopropyl, isopropyl, methyl, and piperidin-4-yl. 
     In one embodiment, R 3  is 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In one embodiment, R 3  is 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In certain embodiments, R 4  is aryl optionally substituted with one to three substituents independently selected from the group consisting of —CN, halo, —O—R 12 , —C(O)—R 12 , C 1-9  alkyl, C 1-9  haloalkyl, and heterocyclyl. 
     (2-(difluoromethyl)phenyl, (2-(hydroxymethyl)phenyl, [1,1′-biphenyl]-2-yl, [1,1′-biphenyl]-3-yl, 1-methylphenyl, 2-((dimethylamino)methyl)phenyl, 2-(difluoromethyl)phenyl, 2-(hydroxycarbonyl)phenyl, 2-(hydroxymethyl)phenyl, 2-(morpholinomethyl)phenyl, 2-(trifluoromethoxy)phenyl, 2-(trifluoromethyl)phenyl, 2,3-dichlorophenyl, 2,3-difluorophenyl, 2,4,6-trifluorophenyl, 2,4-difluorophenyl, 2-chloro-3-cyanophenyl, 2-chloro-4-fluorophenyl, 2-chloro-5-cyanophenyl, 2-chloro-6-fluorophenyl, 2-chlorophenyl, 2-cyanophenyl, 2-fluorophenyl, 2-methylphenyl, 2-methyl-3-(1H-1,2,3-triazol-1-yl)phenyl, 2-methyl-3-(1H-1,2,4-triazol-1-yl)phenyl, 2-methyl-3-(1H-pyrazol-1-yl)phenyl, 2-methyl-3-(1H-tetrazol-1-yl)phenyl, 2-methyl-3-(2H-1,2,3-triazol-2-yl)phenyl, 2-methyl-3-(4H-1,2,4-triazol-4-yl)phenyl, 2-methyl-3-(oxazol-2-yl)phenyl, 3-(((2-(dimethylamino)ethyl)(methyl)amino)methyl)phenyl, 3-(((2-(dimethylamino)ethyl)amino)methyl)phenyl, 3-((2-(dimethylamino)ethoxy)methyl)phenyl, 3-((3,3-difluoroazetidin-1-yl)methyl)phenyl, 3-((dimethylamino)methyl)phenyl, 3-(1,1-dioxidoisothiazolidin-2-yl)phenyl, 3-(1,3-dioxolan-2-yl)phenyl, 3-(1H-1,2,4-triazol-1-yl)phenyl, 3-(1H-imidazol-1-yl)-2-methylphenyl, 3-(1H-imidazol-1-yl)phenyl, 3-(1H-pyrazol-1-yl)phenyl, 3-(1-hydroxy-2,2-dimethylpropyl)phenyl, 3-(1-hydroxyethyl)phenyl, 3-(1-methyl-1H-imidazol-2-yl)phenyl, 3-(2-hydroxypropan-2-yl)phenyl, 3-(2-methylazetidine-1-carbonyl)phenyl, 3-(2-oxoazetidin-1-yl)phenyl, 3-(2-oxopiperidin-1-yl)phenyl, 3-(2-oxopyrrolidin-1-yl)phenyl, 3-(3-(dimethylamino)azetidine-1-carbonyl)phenyl, 3-(3,3-difluoroazetidine-1-carbonyl)phenyl, 3-(3-fluoroazetidine-1-carbonyl)phenyl, 3-(3-hydroxyazetidine-1-carbonyl)phenyl, 3-(3-methoxyazetidine-1-carbonyl)phenyl, 3-(azetidine-1-carbonyl)phenyl, 3-(dimethylamino)phenyl, 3-(dimethylcarbamoyl)phenyl, 3-(ethyl(methyl)carbamoyl)phenyl, 3-(hydroxycarbonyl)phenyl, 3-(hydroxymethyl)phenyl, 3-(methoxycarbonyl)phenyl, 3-(methoxymethyl)phenyl, 3-(methylamino)phenyl, 3-(methylcarbamoyl)phenyl, 3-(methylsulfonamido)phenyl, 3-(methylsulfonyl)phenyl, 3-(morpholinomethyl)phenyl, 3-(N,N-dimethylaminosulfonyl)phenyl, 3-(N-methylacetamido)phenyl, 3-(N-methylmethylsulfonamido)phenyl, 3-(oxazol-2-yl)phenyl, 3-(piperidine-1-carbonyl)phenyl, 3-(pyrrolidin-1-ylmethyl)phenyl, 3-(pyrrolidine-1-carbonyl)phenyl, 3-(thiazol-2-yl)phenyl, 3-(trifluoromethyl)phenyl, 3,4,5-trifluorophenyl, 3,4-dichlorophenyl, 3,4-difluorophenyl, 3,5-bis(trifluoromethyl)phenyl, 3-acetamidophenyl, 3-acetylphenyl, 3-aminophenyl, 3-carbamoylphenyl, 3-chlorophenyl, 3-cyano-2-methylphenyl, 3-cyano-4-fluorophenyl, 3-cyanophenyl, 3-fluorophenyl, 3-formylphenyl, 3-iodophenyl, 3-methoxyphenyl, 3-tert-butylcarbonylphenyl, 4-((dimethylamino)methyl)phenyl, 4-(trifluoromethoxy)phenyl, 4-chlorophenyl, 4-cyanophenyl, 4-fluoro-2-methylphenyl, 4-fluorophenyl, 4-methylphenyl, naphthalen-1-yl, naphthalen-2-yl, N-methyl-3-carbamoylphenyl, or phenyl. 
     In one embodiment, R 4  is 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In one embodiment, R 4  is 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In one embodiment, R 4  is 2-chlorophenyl, 3-(dimethylcarbamoyl)phenyl, 3-cyanophenyl, 4-chlorophenyl, 4-fluorophenyl, or phenyl. 
     In certain embodiments, R 5  is hydrogen, halo, —CN, —S(O)—R 7 , —S(O) 2 R 7 , —SO 2 N(R 7 ) 2 , —C(O)R 7 , —C(O)N(R 7 ) 2 , C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, aryl, heterocyclyl, or heteroaryl; wherein each C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, aryl, heterocyclyl, and heteroaryl may be optionally substituted with one to four Z 5 . 
     In one embodiment, R 5  is hydrogen, halo, —CN, —C(O)R 7 , —S(O) 2 R 7 , or heteroaryl. In one embodiment, R 5  is hydrogen, halo, —CN, —C(O)R 7 , or heteroaryl. In another embodiment, R 5  is halo. 
     In certain embodiments, R 5  is 1H-pyrazol-4-yl, 1-hydroxyethyl, 1-methyl-1H-pyrazol-4-yl, 4-(acetylamino)phenyl, 6-fluoropyridin-3-yl, acetyl, bromo, chloro, cyano, cyclopropyl, dimethylaminocarbonyl, ethynyl, fluoro, iodo, methoxy, methyl, hydroxyl, phenyl, pyridin-3-yl, pyridin-4-yl, pyrimidin-5-yl, or trifluoromethyl. In one embodiment, R 5  is chloro. In certain embodiments, R 5  is 1H-pyrazol-4-yl, 1-hydroxyethyl, 1-methyl-1H-pyrazol-4-yl, 4-(acetylamino)phenyl, 6-fluoropyridin-3-yl, acetyl, bromo, chloro, cyano, cyclopropyl, dimethylaminocarbonyl, ethynyl, fluoro, iodo, methoxy, methyl, methylsulfonyl, hydroxyl, phenyl, pyridin-3-yl, pyridin-4-yl, pyrimidin-5-yl, or trifluoromethyl. In one embodiment, R 5  is chloro. 
     In one embodiment, m is 0. In another embodiment, m is 1. 
     In general, the specific compounds exemplified herein are named using ChemBioDraw Ultra. However, it is understood that other names may be used to identify compounds of the same structure. In particular, the compounds may also be named using other nomenclature systems and symbols that are commonly recognized in the art of chemistry including, for example, Chemical Abstract Service (CAS) and International Union of Pure and Applied Chemistry (IUPAC). Other compounds or radicals may be named with common names, or systematic or non-systematic names. 
     In certain embodiments, provided are optical isomers, racemates, or other mixtures thereof of the compounds described herein or pharmaceutically acceptable salts or a mixture thereof. In those situations, the single enantiomer or diastereomer, i.e., optically active form, can be obtained by asymmetric synthesis or by resolution. Resolution can be accomplished, for example, by conventional methods such as crystallization in the presence of a resolving agent, or chromatography, using for example, a chiral high pressure liquid chromatography (HPLC) column. 
     Compositions provided herein that include a compound described herein or pharmaceutically acceptable salts, isomer, or a mixture thereof may include racemic mixtures, or mixtures containing an enantiomeric excess of one enantiomer or single diastereomers or diastereomeric mixtures. All such isomeric forms of these compounds are expressly included herein as if each and every isomeric form were specifically and individually listed. 
     A composition comprising a mixture of enantiomers (or diastereomers) of a compound described herein or a pharmaceutically acceptable salt thereof, is also provided herein. In some embodiments, the composition comprises a single enantiomer of the compound and is substantially free of the other enantiomer. In certain embodiments, the compound of Formula I (or another Formula as described herein) contains one or more additional stereogenic atom(s) (e.g., at R 1  and/or R 3 ). In such instances, the composition may contain a mixture of diastereomers. In some embodiments, the composition comprises a single enantiomer of the compound and is substantially free (i.e., having less than or about 40%, 30%, 25%, 20%, 15%, 10%, 5%, 1%, 0.05%, or 0.01%) of one or more diastereomers. 
     In certain embodiments, provided is a composition comprising a mixture of Formula IA, or a pharmaceutically acceptable salt thereof, and Formula IB, or a pharmaceutically acceptable salt thereof. 
                         
wherein m, R 1 , R 2 , R 3 , R 4 , R 5 , R 6  and R 15  are as defined herein.
 
     The stereochemistry of the R 4  group depicted in Formula IA may be represented in an alternative way, provided that the configuration of the carbon atom to which it is attached is not altered. For example, compounds of Formula 1A may be depicted in any one of the equivalent representations of Formula IA shown below. 
     
       
         
         
             
             
         
       
     
     In one embodiment, the mixture is a racemic mixture. In other embodiments, the composition comprises a mixture of Formula IA, or a pharmaceutically acceptable salt thereof, and Formula IB, or a pharmaceutically acceptable salt thereof, wherein Formula IA is present in excess of over Formula IB, or a pharmaceutically acceptable salt thereof. In certain embodiments, provided is a composition substantially free of Formula IB, having less than or about 40%, 30%, 25%, 20%, 15%, 10%, 5%, 1%, 0.05%, or 0.01% of compounds of Formula IB. 
     In certain embodiments, provided here in is a composition comprising a mixture of stereoisomers of a compound of Formula I: 
                         
wherein the mixture comprises compounds of Formula IA and IB in a ratio of at least about 3:1:
 
                         
wherein m, R 1 , R 2 , R 3 , R 4 , R 5 , R 6  and R 15  are as defined herein.
 
     In other embodiments, the mixture comprises compounds of Formula IA and IB in a molar ratio of at least or about 3:1, at least or about 4:1, at least or about 5:1, at least or about 6:1, at least or about 7:1, at least or about 8:1, at least or about 9:1, at least or about 10:1, at least or about 11:1, at least or about 12:1, at least or about 20:1, at least or about 30:1, at least or about 40:1, at least or about 80:1, at least or about 160:1, or at least or about 320:1, respectively. 
     In certain embodiments, provided are also chelates, non-covalent complexes, and mixtures thereof, of the compounds described herein or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof. A “chelate” is formed by the coordination of a compound to a metal ion at two (or more) points. A “non-covalent complex” is formed by the interaction of a compound and another molecule wherein a covalent bond is not formed between the compound and the molecule. For example, complexation can occur through van der Waals interactions, hydrogen bonding, and electrostatic interactions (also called ionic bonding). 
     In certain embodiments, provided are prodrugs of the compounds described herein. “Prodrug” refers to any compound that when administered to a biological system generates the drug substance, or active ingredient, as a result of spontaneous chemical reaction(s), enzyme catalyzed chemical reaction(s), photolysis, and/or metabolic chemical reaction(s). A prodrug is thus a covalently modified analog or latent form of a therapeutically active compound. Non-limiting examples of prodrugs include ester moieties, quaternary ammonium moieties, glycol moieties, and the like. 
     In certain embodiments, provided is a compound of Formula I, IA, IB, II, IIA, III, IIIA, IV, IVA, V, VA, VI, VIA, VII, VIIA, VIII or VIIIA, wherein R 6  is 
                         
where each R 12  is independently hydrogen, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, aryl, heteroaryl or heterocyclyl;
         wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with one to four Z 1b  groups; and
 
each Z 1b  is independently oxo, thioxo, hydroxy, halo, —NO 2 , —N 3 , —CN, C 1-9  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-15  cycloalkyl, C 1-8  haloalkyl, aryl, heteroaryl, heterocyclyl, —O(C 1-9  alkyl), —O(C 2-6  alkenyl), —O(C 2-6  alkynyl), —O(C 3-15  cycloalkyl), —O(C 1-8  haloalkyl), —O(aryl), —O(heteroaryl), —O(heterocyclyl), —NH 2 , —NH(C 1-9  alkyl), —NH(C 2-6  alkenyl), —NH(C 2-6  alkynyl), —NH(C 3-15  cycloalkyl), —NH(C 1-8  haloalkyl), —NH(aryl), —NH(heteroaryl), —NH(heterocyclyl), —N(C 1-9  alkyl) 2 , —N(C 3-15  cycloalkyl) 2 , —N(C 2-6  alkenyl) 2 , —N(C 2-6  alkynyl) 2 , —N(C 3-15  cycloalkyl) 2 , —N(C 1-8  haloalkyl) 2 , —N(aryl) 2 , —N(heteroaryl) 2 , —N(heterocyclyl) 2 , —N(C 1-9  alkyl)(C 3-15  cycloalkyl), —N(C 1-9  alkyl)(C 2-6  alkenyl), —N(C 1-9  alkyl)(C 2-6  alkynyl), —N(C 1-9  alkyl)(C 3-15  cycloalkyl), —N(C 1-9  alkyl)(C 1-8  haloalkyl), —N(C 1-9  alkyl)(aryl), —N(C 1-9  alkyl)(heteroaryl), —N(C 1-9  alkyl)(heterocyclyl), —C(O)(C 1-9  alkyl), —C(O)(C 2-6  alkenyl), —C(O)(C 2-6  alkynyl), —C(O)(C 3-15  cycloalkyl), —C(O)(C 1-8  haloalkyl), —C(O)(aryl), —C(O)(heteroaryl), —C(O)(heterocyclyl), —C(O)O(C 1-9  alkyl), —C(O)O(C 2-6  alkenyl), —C(O)O(C 2-6  alkynyl), —C(O)O(C 3-15  cycloalkyl), —C(O)O(C 1-8  haloalkyl), —C(O)O(aryl), —C(O)O(heteroaryl), —C(O)O(heterocyclyl), —C(O)NH 2 , —C(O)NH(C 1-9  alkyl), —C(O)NH(C 2-6  alkenyl), —C(O)NH(C 2-6  alkynyl), —C(O)NH(C 3-15  cycloalkyl), —C(O)NH(C 1-8  haloalkyl), —C(O)NH(aryl), —C(O)NH(heteroaryl), —C(O)NH(heterocyclyl), —C(O)N(C 1-9  alkyl) 2 , —C(O)N(C 3-15  cycloalkyl) 2 , —C(O)N(C 2-6  alkenyl) 2 , —C(O)N(C 2-6  alkynyl) 2 , —C(O)N(C 3-15  cycloalkyl) 2 , —C(O)N(C 1-8  haloalkyl) 2 , —C(O)N(aryl) 2 , —C(O)N(heteroaryl) 2 , —C(O)N(heterocyclyl) 2 , —NHC(O)(C 1-9  alkyl), —NHC(O)(C 2-6  alkenyl), —NHC(O)(C 2-6  alkynyl), —NHC(O)(C 3-15  cycloalkyl), —NHC(O)(C 1-8  haloalkyl), —NHC(O)(aryl), —NHC(O)(heteroaryl), —NHC(O)(heterocyclyl), —NHC(O)O(C 1-9  alkyl), —NHC(O)O(C 2-6  alkenyl), —NHC(O)O(C 2-6  alkynyl), —NHC(O)O(C 3-15  cycloalkyl), —NHC(O)O(C 1-8  haloalkyl), —NHC(O)O(aryl), —NHC(O)O(heteroaryl), —NHC(O)O(heterocyclyl), —NHC(O)NH(C 1-9  alkyl), —NHC(O)NH(C 2-6  alkenyl), —NHC(O)NH(C 2-6  alkynyl), —NHC(O)NH(C 3-15  cycloalkyl), —NHC(O)NH(C 1-8  haloalkyl), —NHC(O)NH(aryl), —NHC(O)NH(heteroaryl), —NHC(O)NH(heterocyclyl), —SH, —S(C 1-9  alkyl), —S(C 2-6  alkenyl), —S(C 2-6  alkynyl), —S(C 3-15  cycloalkyl), —S(C 1-8  haloalkyl), —S(aryl), —S(heteroaryl), —S(heterocyclyl), —NHS(O)(C 1-9  alkyl), —N(C 1-9  alkyl)(S(O)(C 1-9  alkyl), —S(O)N(C 1-9  alkyl) 2 , —S(O)(C 1-9  alkyl), —S(O)(NH)(C 1-9  alkyl), —S(O)(C 2-6  alkenyl), —S(O)(C 2-6  alkynyl), —S(O)(C 3-15  cycloalkyl), —S(O)(C 1-8  haloalkyl), —S(O)(aryl), —S(O)(heteroaryl), —S(O)(heterocyclyl), —S(O) 2 (C 1-9  alkyl), —S(O) 2 (C 2-6  alkenyl), —S(O) 2 (C 2-6  alkynyl), —S(O) 2 (C 3-15  cycloalkyl), —S(O) 2 (C 1-8  haloalkyl), —S(O) 2 (aryl), —S(O) 2 (heteroaryl), —S(O) 2 (heterocyclyl), —S(O) 2 NH(C 1-9  alkyl), or —S(O) 2 N(C 1-9  alkyl) 2 ;
   wherein any alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with one to four halo, C 1-9  alkyl, C 1-8  haloalkyl, —OH, —NH 2 , —NH(C 1-9  alkyl), —NH(C 3-15  cycloalkyl), —NH(C 1-8  haloalkyl), —NH(aryl), —NH(heteroaryl), —NH(heterocyclyl), —N(C 1-9  alkyl) 2 , —N(C 3-15  cycloalkyl) 2 , —NHC(O)(C 3-15  cycloalkyl), —NHC(O)(C 1-8  haloalkyl), —NHC(O)(aryl), —NHC(O)(heteroaryl), —NHC(O)(heterocyclyl), —NHC(O)O(C 1-9  alkyl), —NHC(O)O(C 2-6  alkynyl), —NHC(O)O(C 3-15  cycloalkyl), —NHC(O)O(C 1-8  haloalkyl), —NHC(O)O(aryl), —NHC(O)O(heteroaryl), —NHC(O)O(heterocyclyl), —NHC(O)NH(C 1-9  alkyl), —S(O)(NH)(C 1-9  alkyl), S(O) 2 (C 1-9  alkyl), —S(O) 2 (C 3-15  cycloalkyl), —S(O) 2 (C 1-8  haloalkyl), —S(O) 2 (aryl), —S(O) 2 (heteroaryl), —S(O) 2 (heterocyclyl), —S(O) 2 NH(C 1-9  alkyl), —S(O) 2 N(C 1-9  alkyl) 2 , —O(C 3-15  cycloalkyl), —O(C 1-8  haloalkyl), —O(aryl), —O(heteroaryl), —O(heterocyclyl), or —O(C 1-9  alkyl).       

     In certain embodiments, R 6  is 
                         
and each R 12  is independently as defined herein.
 
     In certain embodiments, R 6  is 
     
       
         
         
             
             
         
       
     
     R 6  also includes all individual stereoisomers, and mixtures thereof, including but not limited to, chirality at the phosphorous atom such as in the exemplary moieties shown above. 
     Also provided herein are the in vivo metabolic products of the compounds described herein. Such products may result, for example, from the oxidation, reduction, hydrolysis, amidation, esterification, and the like, of the administered compound, primarily due to enzymatic processes. 
     Therapeutic Uses of the Compounds 
     “Treatment” or “treating” is an approach for obtaining beneficial or desired results including clinical results. Beneficial or desired clinical results may include one or more of the following: a) inhibiting the disease or condition (e.g., decreasing one or more symptoms resulting from the disease or condition, and/or diminishing the extent of the disease or condition); b) slowing or arresting the development of one or more clinical symptoms associated with the disease or condition (e.g., stabilizing the disease or condition, preventing or delaying the worsening or progression of the disease or condition, and/or preventing or delaying the spread (e.g., metastasis) of the disease or condition); and/or c) relieving the disease, that is, causing the regression of clinical symptoms (e.g., ameliorating the disease state, providing partial or total remission of the disease or condition, enhancing effect of another medication, delaying the progression of the disease, increasing the quality of life, and/or prolonging survival. 
     “Prevention” or “preventing” means any treatment of a disease or condition that causes the clinical symptoms of the disease or condition not to develop. Compounds may, in some embodiments, be administered to a subject (including a human) who is at risk or has a family history of the disease or condition. 
     “Subject” refers to an animal, such as a mammal (including a human), that has been or will be the object of treatment, observation or experiment. The methods described herein may be useful in human therapy and/or veterinary applications. In some embodiments, the subject is a mammal. In one embodiment, the subject is a human. 
     The term “therapeutically effective amount” or “effective amount” of a compound described herein or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof means an amount sufficient to effect treatment when administered to a subject, to provide a therapeutic benefit such as amelioration of symptoms or slowing of disease progression. For example, a therapeutically effective amount may be an amount sufficient to decrease a symptom of a disease or condition responsive to inhibition of Cot activity. The therapeutically effective amount may vary depending on the subject, and disease or condition being treated, the weight and age of the subject, the severity of the disease or condition, and the manner of administering, which can readily be determined by one or ordinary skill in the art. 
     The term “inhibition” indicates a decrease in the baseline activity of a biological activity or process. “Inhibition of activity of Cot” or variants thereof refers to a decrease in activity in Cot as a direct or indirect response to the presence of a compound of the present application relative to the activity Cot in the absence of the compound of the present application. “Inhibition of Cot” refers to a decrease in Cot activity as a direct or indirect response to the presence of a compound described herein relative to the activity of Cot in the absence of the compound described herein. In some embodiments, the inhibition of Cot activity may be compared in the same subject prior to treatment, or other subjects not receiving the treatment. 
     The methods described herein may be applied to cell populations in vivo or ex vivo. “In vivo” means within a living individual, as within an animal or human. In this context, the methods described herein may be used therapeutically in an individual. “Ex vivo” means outside of a living individual. Examples of ex vivo cell populations include in vitro cell cultures and biological samples including fluid or tissue samples obtained from individuals. Such samples may be obtained by methods well known in the art. Exemplary biological fluid samples include blood, cerebrospinal fluid, urine, and saliva. Exemplary tissue samples include tumors and biopsies thereof. In this context, the compounds and compositions described herein may be used for a variety of purposes, including therapeutic and experimental purposes. For example, the compounds and compositions described herein may be used ex vivo to determine the optimal schedule and/or dosing of administration of a Cot inhibitor for a given indication, cell type, individual, and other parameters. Information gleaned from such use may be used for experimental purposes or in the clinic to set protocols for in vivo treatment. Other ex vivo uses for which the compounds and compositions described herein may be suited are described below or will become apparent to those skilled in the art. The selected compounds may be further characterized to examine the safety or tolerance dosage in human or non-human subjects. Such properties may be examined using commonly known methods to those skilled in the art. 
     The compounds disclosed herein are useful for the treatment of diseases or conditions mediated by Cot. Non-limiting examples of diseases or conditions mediated by Cot include, without limitation, cancer, diabetes, and inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), inflammatory bowel disease (IBD), sepsis, psoriasis, misregulated TNF expression and graft rejection. 
     In further embodiments, the methods are provided for alleviating a symptom of a disease or disorder mediated by Cot. In some embodiments, the methods include identifying a mammal having a symptom of a disease or disorder mediated by Cot, and providing to the mammal an amount of a compound as described herein effective to ameliorate (i.e., lessen the severity of) the symptom. 
     In some embodiments, the disease or condition mediated by Cot is a solid tumor. In particular embodiments, the solid tumor is from pancreatic cancer, bladder cancer, colorectal cancer, breast cancer, prostate cancer, renal cancer, hepatocellular cancer, lung cancer, ovarian cancer, cervical cancer, gastric cancer, esophageal cancer, head and neck cancer, melanoma, neuroendocrine cancers, CNS cancers, brain tumors (e.g., glioma, anaplastic oligodendroglioma, adult glioblastoma multiforme, and adult anaplastic astrocytoma), bone cancer, or soft tissue sarcoma. In some embodiments, the solid tumor is from non-small cell lung cancer, small-cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer, or breast cancer. 
     In some embodiments, the disease or condition mediated by Cot is diabetes, which includes any metabolic disorder characterized by impaired insulin production and glucose tolerance. In some embodiments, diabetes includes type 1 and type 2 diabetes, gestational diabetes, prediabetes, insulin resistance, metabolic syndrome, impaired fasting glycaemia and impaired glucose tolerance. Type 1 diabetes is also known as Insulin Dependent Diabetes Mellitus (IDDM). Type 2 is also known as Non-Insulin-Dependent Diabetes Mellitus (NIDDM). 
     In some embodiments, the disease or condition mediated by Cot is an inflammatory disease or LPS induced endotoxin shock. In some embodiments, the disease is an autoimmune disease. In particular embodiments, the autoimmune disease is systemic lupus erythematosus (SLE), myasthenia gravis, rheumatoid arthritis (RA), acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiple sclerosis (MS), inflammatory bowel disease (IBD), sepsis, psoriasis, Sjoegren&#39;s syndrome, psoriasis, autoimmune hemolytic anemia, asthma, or chronic obstructive pulmonary disease (COPD). In other embodiments, the disease is inflammation. In yet other embodiments, the disease is excessive or destructive immune reactions, such as asthma, rheumatoid arthritis, multiple sclerosis, chronic obstructive pulmonary disease (COPD), and lupus. 
     In some embodiments, the disease or condition mediated by Cot is inflammatory bowel disease (IBD). The term “inflammatory bowel disease” or “IBD” as used herein is a collective term describing inflammatory disorders of the gastrointestinal tract, the most common forms of which are ulcerative colitis and Crohn&#39;s disease. Other forms of IBD that can be treated with the presently disclosed compounds, compositions and methods include diversion colitis, ischemic colitis, infectious colitis, chemical colitis, microscopic colitis (including collagenous colitis and lymphocytic colitis), atypical colitis, pseudomembranous colitis, fulminant colitis, autistic enterocolitis, indeterminate colitis, Behçet&#39;s disease, gastroduodenal CD, jejunoileitis, ileitis, ileocolitis, Crohn&#39;s (granulomatous) colitis, irritable bowel syndrome, mucositis, radiation induced enteritis, short bowel syndrome, celiac disease, stomach ulcers, diverticulitis, pouchitis, proctitis, and chronic diarrhea. 
     Treating or preventing IBD also includes ameliorating or reducing one or more symptoms of IBD. As used herein, the term “symptoms of IBD” refers to detected symptoms such as abdominal pain, diarrhea, rectal bleeding, weight loss, fever, loss of appetite, and other more serious complications, such as dehydration, anemia and malnutrition. A number of such symptoms are subject to quantitative analysis (e.g. weight loss, fever, anemia, etc.). Some symptoms are readily determined from a blood test (e.g. anemia) or a test that detects the presence of blood (e.g. rectal bleeding). The term “wherein said symptoms are reduced” refers to a qualitative or quantitative reduction in detectable symptoms, including but not limited to a detectable impact on the rate of recovery from disease (e.g. rate of weight gain). The diagnosis is typically determined by way of an endoscopic observation of the mucosa, and pathologic examination of endoscopic biopsy specimens. 
     The course of IBD varies, and is often associated with intermittent periods of disease remission and disease exacerbation. Various methods have been described for characterizing disease activity and severity of IBD as well as response to treatment in subjects having IBD. Treatment according to the present methods are generally applicable to a subject having IBD of any level or degree of disease activity. 
     Criteria useful for assessment of disease activity in subjects with ulcerative colitis can be found in, e.g., Truelove et al. (1955) Br Med J 2:1041-1048.) Using these criteria, disease activity can be characterized in a subject having IBD as mild disease activity or severe disease activity. Subjects who do not meet all the criteria for severe disease activity, and who exceed the criteria for mild disease activity are classified as having moderate disease activity. 
     The presently disclosed treatment methods can also be applied at any point in the course of the disease. In certain embodiments, the methods are applied to a subject having IBD during a time period of remission (i.e., inactive disease). In such embodiments, the present methods provide benefit by extending the time period of remission (e.g., extending the period of inactive disease) or by preventing, reducing, or delaying the onset of active disease. In other embodiments, methods may be applied to a subject having IBD during a period of active disease. Such methods provide benefit by reducing the duration of the period of active disease, reducing or ameliorating one or more symptoms of IBD, or treating IBD. 
     Measures for determining efficacy of treatment of IBD in clinical practice have been described and include, for example, the following: symptom control; fistula closure; extent of corticosteroid therapy required; and, improvement in quality of life. Heath-related quality of life (HRQL) can be assessed using the Inflammatory Bowel Disease Questionnaire (IBDQ), which is extensively used in clinical practice to assess quality of life in a subject with IBD. (See Guyatt et al. (1989) Gastroenterology 96:804-810.) Improvements in any of the foregoing response criteria are specifically provided by the methods of the present disclosure. 
     Combination Therapies 
     In one embodiment, the compounds disclosed herein may be used in combination with one or more additional therapeutic agent that are being used and/or developed to treat inflammatory disorders (e.g., IBD). The one or more additional therapeutic agent may be a α4β7 inhibitor, a steroid, a MMP-9 antibody, a S1P1 agonist, a TNF biologic, or any combination thereof. 
     In some embodiments, the one or more additional therapeutic agent may be a α4β7 integrin inhibitor, or an agent that inhibits the expression and/or activity of α4β7 integrin. The inhibitor can be small molecule or biologic. For example, the α4β7 integrin inhibitor can be natalizumab or vedolizumab. 
     In some embodiments, the one or more additional therapeutic agent may be a steroid, including but not limited to, corticosteroids. Corticosteroids may be administered by various routes, including intravenously (i.e., methylprednisolone, hydrocortisone), orally (i.e., prednisone, prednisolone, budesonide, dexamethasone), or topically (i.e., enema, suppository, or foam preparations). 
     In some embodiments, the one or more additional therapeutic agent may be an MMP9 inhibitor, or an agent that inhibits the expression and/or activity of MMP9. A representative protein sequence for MMP9 is GenBank Accession No. NP_004985. The inhibitor can be small molecule or biologic. For instance, Gu et al.,  The Journal of Neuroscience,  25(27): 6401-6408 (2005) discloses a specific MMP9 inhibitor, SB-3CT (CAS 292605-14-2). Further, siRNA, antisense RNA and antibodies have also been demonstrated to inhibit the expression or activity of MMP9 and are within the scope of the present disclosure. In one embodiment, an MMP9 inhibitor is a monoclonal anti-MMP9 antibody. In some embodiment, the one or more additional therapeutic agent includes an MMP9 inhibitor and a nucleoside analog such as gemcitabine. 
     In some embodiments, the one or more additional therapeutic agent may be a Sphingosine 1-Phosphate Receptor (S1P1) inhibitor, or an agent that inhibits the expression and/or activity of S1P1. The inhibitor can be small molecule or biologic. For example, the S1P1 inhibitor can be RPC1063. 
     In some embodiments, the one or more additional therapeutic agent may be a TNF inhibitor, or an agent that inhibits the expression and/or activity of TNF. The inhibitor can be small molecule or biologic. For example, the TNF inhibitor can be golimumab. 
     In some embodiments, the one or more additional therapeutic agent is being used and/or developed to treat ulcerative colitis (UC) and/or Crohn disease (CD). The agent can be a biologic or small molecule. In some embodiments, the agent is a modulator (e.g., agonist or antagonist) of S1P1, IL-6, CX3CL1, DHODH, α4, β7, JAK, TNF, CB, IL-12/IL-23, CCL20, TLR9, MAdCAM, CCR9, CXCL10, Smad7, PDE4, MC, VLA-1, GC, GATA-3, Eotaxin, FFA2, LIGHT, FMS, MMP9, CD40, Steroid, 5-ASA, Immunomod, STAT3, and/or EP4. 
     Non-limiting examples of agents being used and/or developed to treat ulcerative colitis (UC) include GSK3050002 (CCL20 modulator, by GSK), GS-5745 (MMP9 modulator, by Gilead), AVX-470 (TNF modulator, by Avaxia), Bertilimumab (Eotaxin modulator, bylmmune Pharma), Simponi (TNF modulator, by Johnson &amp; Johnson and Merck), RX-10001 (by Resolvyx), IBD-98 (5-ASA modulator, by Holy Stone), SP-333 (GC modulator, by Synergy), KAG-308 (EP4 modulator, by Kaken), SB012 (GATA-3 modulator, by Sterna), AJM300 (α4 modulator, by Ajinomoto), BL-7040 (TLR9 modulator, by BiolineRx), TAK-114 (SAT3 modulator, by Takeda), CyCol (by Sigmoid), GWP-42003 (CB modulator, by GW Pharma), ASP3291 (MC modulator, by Drais), GLPG0974 (FFA2 modulator, by Galapagos), Ozanimod (S1P1 modulator, by Receptos), ASP015K (JAK modulator, by Astellas), Apremilast (PDE4 modulator, by Celgene), Zoenasa (by Altheus), Kappaproct (TLR9 modulator, bylnDex), Phosphatidylcholine (by Dr Falk/Lipid Tx), Tofacitinib (JAk modulator, by Pfizer), Cortment (Steroid modulator, by Ferring), Uceris (Steroid modulator, by Salix), and 5-ASA modulators such as Delzicol (by Actavis), Canasa (by Aptalis), Asacol (by Actavis), Pentasa (by Shire/Ferring), Lialda (by Shire), Mezavant (by Shire), Apriso (by Salix), Colazal (by Salix), Giazo (by Salix), and Salofalk (by Dr Falk). Non-limiting examples of agents being used and/or developed to treat Crohn disease (CD) include FFP102 (CD40 modulator, by Fast Forward), E6011 (CX3CL1 modulator, by Eisai), PF-06480605 (by Pfizer), QBECO SSI (Immunomod modulator, by Qu Biologics), PDA-001 (by Celgene), BI 655066 (IL-12/IL-23 modulator, by Boehringer), TNFα kinoid (TNF modulator, by Neovacs), AMG 139/MEDI-2070 (IL-12/IL-23 modulator, by AstraZeneca), PF-04236921 (IL-6 modulator, by Pfizer), Tysabri (β7 modulator, marketed by Biogen Idec in the U.S.), Cimzia (marketed by UCB in the U.S.), JNJ-40346527 (FMS modulator, by J&amp;J), SGX-203 (Steroid modulator, by Solgenix), CyCron (by Sigmoid), CCX507 (CCR9 modulator, by ChemoCentryx), MT1303 (S1P1 modulator, by Mitsubishi), 6-MP (by Teva), ABT-494 (JAk modulator, by Abbvie), Tofacitinib (JAk modulator, by Pfizer), GLPG0634 (JAk modulator, by Galapagos), TRK-170 (β7 modulator, by Toray), Mongersen (Smad7 modulator, by Celgene), RHB-104 (by Redhill), Rifaxmin EIR (by Salix), Budenofalk (by Dr Falk), and Entocort (by AstraZeneca). 
     Non-limiting examples of agents being used and/or developed to treat ulcerative colitis (UC) and Crohn disease (CD) include PF-06410293 (by Pfizer), SAN-300 (VLA-1 modulator, by Salix), SAR252067 (LIGHT modualtor, by Sanofi), PF-00547659 (MAdCAM modualtor, by Pfizer), Eldelumab (Smad7 modulator, by BMS), AMG 181/MEDI-7183 (β7 modulator, by Amgen/AstraZeneca), Etrolizumab (β7 modulator, by Roche), Ustekinumab (IL-12/IL-23 modulator, by J&amp;J), Remicade (TNF modulator, by J&amp;J and Merck), Entyvio (β7 modulator, by Takeda), Humira (TNF modulator, by Abbvie), Infliximab (by Celtrion), PF-06651600 (by Pfizer), GSK2982772 (by GSK), GLPG1205 (FFA2 modulator, by Galapagos), AG014 (by Intrexon) and Vidofludimus (DHODH modulator, by 4SC). 
     In some embodiments, the one or more additional therapeutic agent may be a JAK inhibitor, particularly a JAK-1 selective inhibitor. The inhibitor can be small molecule or biologic. For example, the JAK inhibitor can be Filgotinib, GLPG0634 (JAK modulator, by Galápagos). 
     Kits 
     Provided herein are also kits that include a compound of Formula I, or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof, and suitable packaging. In one embodiment, a kit further includes instructions for use. In one aspect, a kit includes a compound of Formula I (or any other Formula described herein), or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof, and a label and/or instructions for use of the compounds in the treatment of the indications, including the diseases or conditions, described herein. 
     Provided herein are also articles of manufacture that include a compound described herein or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof in a suitable container. The container may be a vial, jar, ampoule, preloaded syringe, and intravenous bag. 
     Pharmaceutical Compositions and Modes of Administration 
     Compounds provided herein are usually administered in the form of pharmaceutical compositions. Thus, provided herein are also pharmaceutical compositions that contain one or more of the compounds described herein or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof and one or more pharmaceutically acceptable vehicles selected from carriers, adjuvants and excipients. Suitable pharmaceutically acceptable vehicles may include, for example, inert solid diluents and fillers, diluents, including sterile aqueous solution and various organic solvents, permeation enhancers, solubilizers and adjuvants. Such compositions are prepared in a manner well known in the pharmaceutical art. See, e.g., Remington&#39;s Pharmaceutical Sciences, Mace Publishing Co., Philadelphia, Pa. 17th Ed. (1985); and Modern Pharmaceutics, Marcel Dekker, Inc. 3rd Ed. (G. S. Banker &amp; C. T. Rhodes, Eds.). 
     The pharmaceutical compositions may be administered in either single or multiple doses. The pharmaceutical composition may be administered by various methods including, for example, rectal, buccal, intranasal and transdermal routes. In certain embodiments, the pharmaceutical composition may be administered by intra-arterial injection, intravenously, intraperitoneally, parenterally, intramuscularly, subcutaneously, orally, topically, or as an inhalant. 
     One mode for administration is parenteral, for example, by injection. The forms in which the pharmaceutical compositions described herein may be incorporated for administration by injection include, for example, aqueous or oil suspensions, or emulsions, with sesame oil, corn oil, cottonseed oil, or peanut oil, as well as elixirs, mannitol, dextrose, or a sterile aqueous solution, and similar pharmaceutical vehicles. 
     Oral administration may be another route for administration of the compounds described herein. Administration may be via, for example, capsule or enteric coated tablets. In making the pharmaceutical compositions that include at least one compound described herein or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof, the active ingredient is usually diluted by an excipient and/or enclosed within such a carrier that can be in the form of a capsule, sachet, paper or other container. When the excipient serves as a diluent, it can be in the form of a solid, semi-solid, or liquid material, which acts as a vehicle, carrier or medium for the active ingredient. Thus, the compositions can be in the form of tablets, pills, powders, lozenges, sachets, cachets, elixirs, suspensions, emulsions, solutions, syrups, aerosols (as a solid or in a liquid medium), ointments containing, for example, up to 10% by weight of the active compound, soft and hard gelatin capsules, sterile injectable solutions, and sterile packaged powders. 
     Some examples of suitable excipients include lactose, dextrose, sucrose, sorbitol, mannitol, starches, gum acacia, calcium phosphate, alginates, tragacanth, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, sterile water, syrup, and methyl cellulose. The formulations can additionally include lubricating agents such as talc, magnesium stearate, and mineral oil; wetting agents; emulsifying and suspending agents; preserving agents such as methyl and propylhydroxy-benzoates; sweetening agents; and flavoring agents. 
     The compositions that include at least one compound described herein or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof can be formulated so as to provide quick, sustained or delayed release of the active ingredient after administration to the subject by employing procedures known in the art. Controlled release drug delivery systems for oral administration include osmotic pump systems and dissolutional systems containing polymer-coated reservoirs or drug-polymer matrix formulations. Examples of controlled release systems are given in U.S. Pat. Nos. 3,845,770; 4,326,525; 4,902,514; and 5,616,345. Another formulation for use in the methods disclosed herein employ transdermal delivery devices (“patches”). Such transdermal patches may be used to provide continuous or discontinuous infusion of the compounds described herein in controlled amounts. The construction and use of transdermal patches for the delivery of pharmaceutical agents is well known in the art. See, e.g., U.S. Pat. Nos. 5,023,252, 4,992,445 and 5,001,139. Such patches may be constructed for continuous, pulsatile, or on demand delivery of pharmaceutical agents. 
     For preparing solid compositions such as tablets, the principal active ingredient may be mixed with a pharmaceutical excipient to form a solid preformulation composition containing a homogeneous mixture of a compound described herein or a pharmaceutically acceptable salt, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or deuterated analog thereof. When referring to these preformulation compositions as homogeneous, the active ingredient may be dispersed evenly throughout the composition so that the composition may be readily subdivided into equally effective unit dosage forms such as tablets, pills and capsules. 
     The tablets or pills of the compounds described herein may be coated or otherwise compounded to provide a dosage form affording the advantage of prolonged action, or to protect from the acid conditions of the stomach. For example, the tablet or pill can include an inner dosage and an outer dosage component, the latter being in the form of an envelope over the former. The two components can be separated by an enteric layer that serves to resist disintegration in the stomach and permit the inner component to pass intact into the duodenum or to be delayed in release. A variety of materials can be used for such enteric layers or coatings, such materials including a number of polymeric acids and mixtures of polymeric acids with such materials as shellac, cetyl alcohol, and cellulose acetate. 
     Compositions for inhalation or insufflation may include solutions and suspensions in pharmaceutically acceptable, aqueous or organic solvents, or mixtures thereof, and powders. The liquid or solid compositions may contain suitable pharmaceutically acceptable excipients as described herein. In some embodiments, the compositions are administered by the oral or nasal respiratory route for local or systemic effect. In other embodiments, compositions in pharmaceutically acceptable solvents may be nebulized by use of inert gases. Nebulized solutions may be inhaled directly from the nebulizing device or the nebulizing device may be attached to a facemask tent, or intermittent positive pressure breathing machine. Solution, suspension, or powder compositions may be administered, preferably orally or nasally, from devices that deliver the formulation in an appropriate manner. 
     Dosing 
     The specific dose level of a compound of the present application for any particular subject will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, sex, diet, time of administration, route of administration, and rate of excretion, drug combination and the severity of the particular disease in the subject undergoing therapy. For example, a dosage may be expressed as a number of milligrams of a compound described herein per kilogram of the subject&#39;s body weight (mg/kg). Dosages of between about 0.1 and 150 mg/kg may be appropriate. In some embodiments, about 0.1 and 100 mg/kg may be appropriate. In other embodiments a dosage of between 0.5 and 60 mg/kg may be appropriate. Normalizing according to the subject&#39;s body weight is particularly useful when adjusting dosages between subjects of widely disparate size, such as occurs when using the drug in both children and adult humans or when converting an effective dosage in a non-human subject such as dog to a dosage suitable for a human subject. 
     The daily dosage may also be described as a total amount of a compound described herein administered per dose or per day. Daily dosage of a compound of Formula I may be between about 1 mg and 4,000 mg, between about 2,000 to 4,000 mg/day, between about 1 to 2,000 mg/day, between about 1 to 1,000 mg/day, between about 10 to 500 mg/day, between about 20 to 500 mg/day, between about 50 to 300 mg/day, between about 75 to 200 mg/day, or between about 15 to 150 mg/day. 
     When administered orally, the total daily dosage for a human subject may be between 1 mg and 1,000 mg, between about 1,000-2,000 mg/day, between about 10-500 mg/day, between about 50-300 mg/day, between about 75-200 mg/day, or between about 100-150 mg/day. 
     The compounds of the present application or the compositions thereof may be administered once, twice, three, or four times daily, using any suitable mode described above. Also, administration or treatment with the compounds may be continued for a number of days; for example, commonly treatment would continue for at least 7 days, 14 days, or 28 days, for one cycle of treatment. Treatment cycles are well known in cancer chemotherapy, and are frequently alternated with resting periods of about 1 to 28 days, commonly about 7 days or about 14 days, between cycles. The treatment cycles, in other embodiments, may also be continuous. 
     In a particular embodiment, the method comprises administering to the subject an initial daily dose of about 1 to 800 mg of a compound described herein and increasing the dose by increments until clinical efficacy is achieved. Increments of about 5, 10, 25, 50, or 100 mg can be used to increase the dose. The dosage can be increased daily, every other day, twice per week, or once per week. 
     Synthesis of the Compounds of Formula I 
     The compounds may be prepared using the methods disclosed herein and routine modifications thereof, which will be apparent given the disclosure herein and methods well known in the art. Conventional and well-known synthetic methods may be used in addition to the teachings herein. The synthesis of typical compounds described herein may be accomplished as described in the following examples. If available, reagents may be purchased commercially, e.g., from Sigma Aldrich or other chemical suppliers. 
     General Synthesis 
     Typical embodiments of compounds described herein may be synthesized using the general reaction schemes described below. It will be apparent given the description herein that the general schemes may be altered by substitution of the starting materials with other materials having similar structures to result in products that are correspondingly different. Descriptions of syntheses follow to provide numerous examples of how the starting materials may vary to provide corresponding products. Given a desired product for which the substituent groups are defined, the necessary starting materials generally may be determined by inspection. Starting materials are typically obtained from commercial sources or synthesized using published methods. For synthesizing compounds which are embodiments described in the present disclosure, inspection of the structure of the compound to be synthesized will provide the identity of each substituent group. The identity of the final product will generally render apparent the identity of the necessary starting materials by a simple process of inspection, given the examples herein. In general, compounds described herein are typically stable and isolatable at room temperature and pressure. 
     Synthetic Reaction Parameters 
     The compounds of this disclosure can be prepared from readily available starting materials using, for example, the following general methods and procedures. It will be appreciated that where typical or preferred process conditions (i.e., reaction temperatures, times, mole ratios of reactants, solvents, pressures, etc.) are given, other process conditions can also be used unless otherwise stated. Optimum reaction conditions may vary with the particular reactants or solvent used, but such conditions can be determined by one skilled in the art by routine optimization procedures. 
     Additionally, as will be apparent to those skilled in the art, conventional protecting groups may be necessary to prevent certain functional groups from undergoing undesired reactions. Suitable protecting groups for various functional groups as well as suitable conditions for protecting and deprotecting particular functional groups are well known in the art. For example, numerous protecting groups are described in T. W. Greene and G. M. Wuts (1999) Protecting Groups in Organic Synthesis, 3rd Edition, Wiley, New York, and references cited therein. 
     Furthermore, the compounds of this disclosure may contain one or more chiral centers. Accordingly, if desired, such compounds can be prepared or isolated as pure stereoisomers, i.e., as individual enantiomers or diastereomers or as stereoisomer-enriched mixtures. All such stereoisomers (and enriched mixtures) are included within the scope of this disclosure, unless otherwise indicated. Pure stereoisomers (or enriched mixtures) may be prepared using, for example, optically active starting materials or stereoselective reagents well-known in the art. Alternatively, racemic mixtures of such compounds can be separated using, for example, chiral column chromatography, chiral resolving agents, and the like. 
     The starting materials for the following reactions are generally known compounds or can be prepared by known procedures or obvious modifications thereof. For example, many of the starting materials are available from commercial suppliers such as Aldrich Chemical Co. (Milwaukee, Wis., USA), Bachem (Torrance, Calif., USA), Emka-Chemce or Sigma (St. Louis, Mo., USA). Others may be prepared by procedures or obvious modifications thereof, described in standard reference texts such as Fieser and Fieser&#39;s Reagents for Organic Synthesis, Volumes 1-15 (John Wiley, and Sons, 1991), Rodd&#39;s Chemistry of Carbon Compounds, Volumes 1-5, and Supplementals (Elsevier Science Publishers, 1989) organic Reactions, Volumes 1-40 (John Wiley, and Sons, 1991), March&#39;s Advanced Organic Chemistry, (John Wiley, and Sons, 5th Edition, 2001), and Larock&#39;s Comprehensive Organic Transformations (VCH Publishers Inc., 1989). 
     The term “solvent” generally refers to a solvent inert under the conditions of the reaction being described in conjunction therewith (including, for example, benzene, toluene, acetonitrile, tetrahydrofuran (THF), dimethylformamide (DMF), chloroform, methylene chloride (or dichloromethane), diethyl ether, methanol, and the like). Unless specified to the contrary, the solvents used in the reactions are inert organic solvents, and the reactions may carried out under an inert gas, preferably argon or nitrogen. 
     The term “q.s.” means adding a quantity sufficient to achieve a stated function, e.g., to bring a solution to the desired volume (i.e., 100%). 
     The compounds of Formula I may prepared by first providing the substituted quinoline core, and optionally further modifying the core as desired to provide the substituents disclosed herein. Scheme 1 shows the preparation of the quinoline core to provide compounds of Formula 1-e, where m, R 5  and R 15  are as defined herein, or is a functional group that may be converted thereto using standard reaction conditions. 
     
       
         
         
             
             
         
       
     
     In Scheme 1, suitably substituted 1-a and 1-b are condensed in a suitable solvent (e.g., DMF, etc.) in the presence of catalyst (e.g., Cs 2 CO 3 , etc.) at an elevated temperature (e.g., about 40-50° C.) to provide 1-c. Compound 1-c is then converted to 1-d under thermal cyclization conditions (i.e., about 250° C.) or under microwave conditions. Chlorination of 1-d to provide 1-e is achieved using a suitable chlorinating agent (e.g., POCl 3 , SOCl 2 , etc.) at an elevated temperature (e.g., about 110-120° C.) in the presence of a base (e.g. pyridine, dimethylaniline, diethylaniline, etc.) or a catalyst (e.g., DMF, DEF, etc.) and in a suitable solvent (e.g. chlorobenzene, CH 3 CN, etc.) or solvent-free conditions (i.e., neat). 
     Scheme 2 shows the synthesis of compounds of Formula 2-c and 2-d where m, R 1 , R 2 , R 5  and R 15  are as defined herein. 
     
       
         
         
             
             
         
       
     
     In Scheme 2, 1-e is reacted with a suitable amine under standard nucleophilic aromatic substitution conditions in the presence of a base (e.g., NEt 3 , etc.) and at elevated temperature (e.g., 150° C.) to obtain 2-a. Compounds of Formula I where R 5  and/or R 15  is cyano are provided by reacting 2-a with a suitable cyanating agent (e.g., CuCN, Zn(CN) 2 , etc.) in the presence of a catalyst (e.g., palladium, nickel, copper, etc.). Compounds 2-c and 2-d are then provided via reduction of the nitro group of compounds 2-a or 2-b, respectively (using e.g., Fe, SnCl 2 , etc.). 
     Scheme 3 shows the synthesis of compounds 3-d and 3-e, where R 4  is as defined herein. 
     
       
         
         
             
             
         
       
     
     In Scheme 3, deuterated 3-c is provided by reducing suitably substituted aldehyde 3-a with a deuteride-containing reducing agent (e.g., NaBD 4 ), followed by oxidation of 3-b to the corresponding aldehyde 3-c under standard oxidizing conditions (e.g., MnO 2 , Fe 2 O 3 , NiO, CuO, ZnO, ZrO 2 , La 2 O 3 , Sm 2 O 3 , Eu 2 O 3 , Yb 2 O 3 , etc.). Compound 3-d is obtained in two steps by reaction of 3-c with ethynyl Grignard, followed by acylation of the resulting alcohol with acetic anhydride in the presence of a base (e.g., pyridine, TEA, etc.). Compound 3-e is provided in a similar two-step process by reacting suitably substituted aldehyde 3-a with ethynyl Grignard, followed by acylation of the resulting alcohol with acetic anhydride. 
     Scheme 4 shows the synthesis of suitably protected azide compounds of Formula 4-b, where Lg is a leaving group and Z 3  is as defined herein. 
     
       
         
         
             
             
         
       
     
     In Scheme 4, suitably substituted amine 4-a is treated with a diazo transfer agent (e.g., imidazole-1-sulfonyl azide hydrochloride) to afford corresponding 4-b. Alternatively, 4-b may be obtained in two steps from alcohol 4-c by conversion of the hydroxyl moiety to a suitable leaving group (Lg) (e.g., TsO—, MsO—, NsO—, TfO—, etc.) followed by nucleophilic displacement with azide. 
     Scheme 5 shows the synthesis of intermediate compounds of Formula 5-c, where R 50  is alkyl and Z 3  is as defined herein. 
     
       
         
         
             
             
         
       
     
     In Scheme 5, suitably substituted triazole 5-b is obtained by reaction of 4-b with 5-a using standard 1,3-dipolar cycloaddition conditions. Acetal 5-b is converted to the corresponding aldehyde 5-c under standard carbonyl deprotection conditions (e.g., aqueous acid). 
     Scheme 6 shows a general synthesis of exemplary compounds of Formula I, where Z 3 , m, R 1 , R 2 , R 4 , R 5  and R 15  and are as defined herein. 
     
       
         
         
             
             
         
       
     
     In Scheme 6, compounds of Formula 6-c can be provided via N-alkylation of amine 2-d with 3-d (or 3-e), followed by cyclization with azide 4-b under standard 1,3-dipolar cycloaddition conditions. Separation of the isomers of Formula 6-a to give compounds of Formula 6-b can be performed using standard chiral separation/resolution techniques (e.g., chiral chromatography, crystallization, etc.). Alternatively, compounds of Formula 6-b can be provided via enantioselective N-alkylation of 2-d with 3-d (or 3-e) using a chiral metal complex (e.g., [Cu(CH 3 CN) 4 ]PF 6 , CuOTf.benzene, Cu(OAc) 2 , or Cu(I)I, etc., with a chiral ligand). Suitable reaction conditions and exemplary chiral ligands/complexes can be found in the literature (see, e.g., Detz, et al. Angew. Chem. Int. Ed. 2008, 47, 3777-3780). Contacting compound 6-c with azide 4-b under standard 1,3-dipolar cycloaddition conditions provides compound 6-b. 6-c may or may not be isolated prior to the addition of compound 4-b. 
     Scheme 7 shows an alternate synthesis of compounds of Formula I via imine formation and subsequent nucleophilic addition, where Z 3 , m, R 1 , R 2 , R 3 , R 4 , R 5  and R 15  are as defined herein. 
     
       
         
         
             
             
         
       
     
     In Scheme 7, amine 2-d is reacted with aldehyde 7-a to afford the corresponding imine 7-b under standard imine-forming conditions. Compound 7-b is then reacted with Grignard reagent 7-c to provide Formula I. Alternatively, 2-d can be reacted with aldehyde 7-d to afford imine 7-e, which is then reacted with ethynyl Grignard to provide compound 7-f. Compound 7-f can then be converted to compound 7-g under standard 1,3-dipolar cycloaddition conditions with 4-b as shown in Scheme 6. Further, resolution of the isomers of Formula I or compound 7-g can be performed using standard chiral separation/resolution conditions (e.g., chiral chromatography, crystallization, etc.). 
     Scheme 8 shows another alternate general synthesis of compounds of Formula I, where m, R 1 , R 2 , R 3 , R 4 , R 5  and R 15  are as defined herein. 
     
       
         
         
             
             
         
       
     
     In Scheme 8, amine 2-d is reacted with appropriately substituted 8-a under nucleophilic substitution conditions, where Lg is a suitable leaving group, such as a halide (e.g., fluoro, chloro, bromo, iodo) or an activated alcohol (e.g., AcO—, TsO—, TfO—, MsO—, etc.) in the presence of a base, to provide compound of Formula I. Alternatively, amine 2-d is reacted with ketone 8-b to provide 8-c, which is subsequently reduced to provide compound of Formula I. Resolution of the isomers of Formula I can be performed using standard chiral separation/resolution conditions (e.g., chiral chromatography, crystallization, etc.). 
     EXAMPLES 
     The following examples are included to demonstrate specific embodiments of the disclosure. It should be appreciated by those of skill in the art that the techniques disclosed in the examples which follow represent techniques to function well in the practice of the disclosure, and thus can be considered to constitute specific modes for its practice. However, those of skill in the art should, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the disclosure. 
     Intermediate Preparation 
     Example Synthesis of a Cyanoquinoline Core: 
     
       
         
         
             
             
         
       
     
     A mixture of 2-chloro-4-nitroaniline (1 eq), (Z)-ethyl 2-cyano-3-ethoxyacrylate (1.3 eq) and Cs 2 CO 3  (1.3 eq) in DMF was heated at 45° C. overnight. After being cooled to room temperature, the mixture was poured into water. The formed solid was filtered, and washed with water and dried to give the title compound as a solid which was used for the next step without further purification. 
       1 H NMR (DMSO-d 6 , 300 MHz): δ 11.28 (d, J=12.9 Hz, 1H), 8.84 (d, J=12.9 Hz, 1H), 8.42 (d, J=2.4 Hz, 1H), 8.26-8.22 (m, 1H), 8.02 (d, J=9.3 Hz, 1H), 4.27 (q, J=7.2 Hz, 2H), 1.27 (t, J=7.2 Hz, 3H). 
     Synthesis of 8-Chloro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carbonitrile 
     
       
         
         
             
             
         
       
     
     A suspension of (Z)-ethyl 3-((2-chloro-4-nitrophenyl)amino)-2-cyanoacrylate in diphenyl ether under nitrogen was heated to reflux with a sand bath in a heating mantle for 24 hours. After cooling to room temperature, the reaction mixture was poured into hexane and stirred for 2 hours. The mixture was filtered and the filter cake was washed with hexane twice to give title compound as a brown solid. 
       1 H NMR (DMSO-d 6 , 300 MHz): δ 12.86 (br s, 1H), 8.73-8.71 (m, 3H). 
     Synthesis of 4,8-Dichloro-6-nitroquinoline-3-carbonitrile 
     
       
         
         
             
             
         
       
     
     A suspension of 8-chloro-6-nitro-4-oxo-1,4-dihydroquinoline-3-carbonitrile and five drops of DMF in POCl 3  was heated at 115° C. overnight. The brown clear solution was cooled down to room temperature and excess of POCl 3  was removed. The residue was dissolved in DCM, washed with sat. NaHCO 3 , brine and dried over Na 2 SO 4 . The solution was filtered and concentrated to give a crude product. The residue was triturated with hexane and EtOAc to afford the title compound as a brown solid. 
       1 H NMR (DMSO-d 6 , 300 MHz): δ 9.50 (s, 1H), 8.98 (d, J=2.4 Hz, 1H), 8.89 (d, J=2.4 Hz, 1H). 
     Example Synthesis of an Alkynylacetate 
     
       
         
         
             
             
         
       
     
     Methyl 3-(1-acetoxyprop-2-yn-1-yl)benzoate 
     methyl 3-formylbenzoate (1.00 g, 6.09 mmol) was dissolved in THF (30 mL) and brought to 0° C. Ethynylmagnesium bromide (0.5 M in THF, 12.8 mL, 6.40 mmol) was added slowly and the resulting solution allowed to stir for 30 minutes. Acetic anhydride (1.15 mL, 12.2 mmol) was then added, the cold bath removed, and the reaction mixture allowed to warm to room temperature over 2 hours. The reaction contents were quenched by the addition of saturated aqueous NH 4 Cl (10 mL), poured into water (10 mL), and extract with EtOAc (3×30 mL). The combined organic phase was washed with brine (15 mL), dried over MgSO 4  and concentrated. The crude residue was purified by flash chromatography (eluent: EtOAc/hexanes) to give the desired product. 
     Synthesis of Selected Aldehydes: 
     
       
         
         
             
             
         
       
     
     4-chlorobenzaldehyde-α-d 
     4-chlorobenzaldehyde (250 mg, 1.78 mmol) was dissolved in MeOH (8 mL) at room temperature. NaBD 4  (89 mg, 2.13 mmol) was then added as a single portion and the reaction mixture stirred for 20 minutes. The reaction mixture was carefully quenched with water (5 mL) and extracted with EtOAc (3×15 mL). The combined organic layers were washed with brine (5 mL), dried over MgSO 4  and concentrated to give crude alcohol which was carried forward without further purification. The crude alcohol was re-dissolved in DCM (10 mL) and manganese(IV) oxide (1.54 g, 17.8 mmol) was added at room temperature. After 2 hours the reaction mixture was filtered through a pad of celite rinsing with DCM and EtOAc. The filtrate was then concentrated to give the desired product with approximately 95% deuterium incorporation. Synthesis of the alkynyl acetate as outlined above. 
     3-(((tert-butyldimethylsilyl)oxy)methyl)benzaldehyde 
     
       
         
         
             
             
         
       
     
     (3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)methanol 
     1,3-phenylenedimethanol (3.00 g, 21.7 mmol) and imidazole (2.22 g, 32.6 mmol) were dissolved in DMF (40 mL) at room temperature. Tert-butyldimethylsilyl chloride (3.27 g, 21.7 mmol) was then added and the reaction stirred overnight. The DMF was removed under reduced pressure, the crude material partitioned between water (30 mL) and EtOAc (50 mL). The aqueous phase was extracted once more with EtOAc (50 mL). The organic layers were then combined, washed with brine (30 mL), dried over MgSO 4  and concentrated. The residue was subjected to flash chromatography (eluent: ethyl acetate/hexanes) to give (3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)methanol. 
     3-(((tert-butyldimethylsilyl)oxy)methyl)benzaldehyde 
     (3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)methanol (2.57 g, 10.2 mmol) was dissolved in DCM (50 mL) at room temperature. Manganese(IV) oxide (2.66 g, 30.6 mmol) was then added and the reaction stirred for 2 hours. Additional manganese(IV) oxide (2.66 g, 30.6 mmol) was then added and the reaction stirred overnight. The reaction mixture was filtered through a pad of celite and the filtrate then concentrated to give 3-(((tert-butyldimethylsilyl)oxy)methyl)benzaldehyde which was used without further purification. 
     
       
         
         
             
             
         
       
     
     3,6-dihydro-2H-pyran-4-carbaldehyde 
     Prepared as described in: Z. S. Han et al  Org. Lett.  2014, 16, 4142-4145. 
     N-(3-formylphenyl)-N-methylacetamide 
     
       
         
         
             
             
         
       
     
     N-(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)acetamide 
     N-(3-(hydroxymethyl)phenyl)acetamide (250 mg, 1.51 mmol) and imidazole (155 mg, 2.27 mmol) were dissolved in DMF (6 mL) at room temperature. Tert-butyldimethylsilyl chloride (240 mg, 1.59 mmol) was then added and the reaction stirred overnight. The DMF was removed under reduced pressure, the crude material partitioned between water (10 mL) and EtOAc (30 mL). The aqueous phase was extracted once more with EtOAc (20 mL). The organic layers were then combined, washed with brine (10 mL), dried over MgSO 4  and concentrated. The residue was subjected to flash chromatography (eluent: ethyl acetate/hexanes) to give (3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)methanol. 
     N-(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-N-methylacetamide 
     N-(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)acetamide (353 mg, 1.26 mmol) was dissolved in THF (10 mL) and brought to 0° C. NaH (60% dispersion in mineral oil, 152 mg, 3.79 mmol) was added and the reaction mixture allowed to stir for 20 minutes after which iodomethane (0.39 mL, 6.3 mmol) was added. The reaction mixture was allowed to warm to room temperature over 1 hour after which it was quenched by water (5 mL) and extracted with EtOAc (3×15 mL). The combined organic phases were washed with brine (10 mL), dried over MgSO 4 , and concentrated to give crude product which was carried forward without further purification. 
     N-(3-(hydroxymethyl)phenyl)-N-methylacetamide 
     N-(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-N-methylacetamide (370 mg, 1.26 mmol) was dissolved in THF (8 mL) and treated with tetrabutylammonium fluoride (1.0M in THF, 2.52 mL, 2.52 mmol) at room temperature for 30 minutes. The reaction contents were quenched by the addition of saturated aqueous NH 4 Cl (5 mL), poured into water (5 mL) and extracted with EtOAc (3×15 mL). The combined organic phases were washed with brine, dried over MgSO 4  and concentrated. The crude residue was purified by flash chromatography (eluent: MeOH/ethyl acetate/hexanes) to give the desired product. 
     N-(3-formylphenyl)-N-methylacetamide 
     N-(3-(hydroxymethyl)phenyl)-N-methylacetamide (159 mg, 0.89 mmol) was dissolved in DCM (8 mL) and manganese(IV) oxide (1.54 g, 17.7 mmol) was added and the resulting mixture stirred at room temperature. After 2 hours the reaction mixture was filtered through celite and the filtrate concentrated to give the desired aldehyde product which was used without further purification. 
     
       
         
         
             
             
         
       
     
     N-(3-formylphenyl)-N-methylmethanesulfonamide 
     N-(3-formylphenyl)methanesulfonamide (465 mg, 2.33 mmol) was dissolved in acetone (10 mL) at room temperature. Powdered K 2 CO 3  (968 mg, 7.00 mmol) and iodomethane (0.29 mL, 4.67 mmol) were then added and the reaction mixture allowed to stir overnight. The reaction mixture was poured into water (5 mL) and extracted with EtOAc (3×15 mL). The combined organic phases were washed with brine (5 mL), dried over MgSO 4  and concentrated to give crude product which was carried on without further purification. 
     3-(2-oxoazetidin-1-yl)benzaldehyde 
     
       
         
         
             
             
         
       
     
     1-(3-(hydroxymethyl)phenyl)azetidin-2-one 
     CuI (19 mg, 0.10 mmol) and K 3 PO 4  (849 mg, 4.00 mmol) were added to a vial which was purged with argon. N,N′-dimethylethylenediamine (0.022 mL, 0.2 mmol), 3-(iodophenyl)methanol (468 mg, 2.00 mmol) and 2-azetidinone (171 mg, 2.4 mmol) were then added followed by toluene (2 mL). The reaction mixture was heated to 80° C. for 90 minutes after which it was cooled to room temperature, passed through a short silica plug washing with EtOAc and MeOH, and concentrated. The crude residue was then purified by flash chromatography (eluent: MeOH/DCM) to give the desired product. 
     3-(2-oxoazetidin-1-yl)benzaldehyde 
     1-(3-(hydroxymethyl)phenyl)azetidin-2-one (350 mg, 1.98 mmol) was dissolved in DCM (8 mL) and manganese(IV) oxide (2.61 g, 30.0 mmol) was added and the resulting mixture stirred at room temperature. After 2 hours the reaction mixture was filtered through celite and the filtrate concentrated to give the desired aldehyde product which was used without further purification. 
     3-(oxazol-2-yl)benzaldehyde 
     
       
         
         
             
             
         
       
     
     (3-(oxazol-2-yl)phenyl)methanol 
     3-(iodophenyl)methanol (0.13 mL, 1.04 mmol), 2-(tri-n-butylstannyl)oxazole) (1.27 mL, 4.15 mmol), tetrakis(triphenylphosphine)palladium(O) (240 mg, 0.21 mmol), and lithium chloride (88 mg, 2.08 mmol) were all combined in DMF (5 mL) and purged with argon. The reaction mixture was then heated overnight at 90° C. after which it was passed through a silica-thiol plug, washing with MeOH and MeCN, and concentrated. The crude residue was purified by flash chromatography (eluent: EtOAc/hexanes) to give the desired product. 
     3-(oxazol-2-yl)benzaldehyde 
     (3-(oxazol-2-yl)phenyl)methanol (174 mg, 0.99 mmol) was dissolved in DCM (8 mL) and manganese(IV) oxide (1.30 g, 14.9 mmol) was added and the resulting mixture stirred at room temperature. After 2 hours the reaction mixture was filtered through celite and the filtrate concentrated to give the desired aldehyde product which was used without further purification. 
     
       
         
         
             
             
         
       
     
     2-methyl-3-(pyridin-4-yl)benzaldehyde 
     3-bromo-2-methylbenzyl alcohol (200 mg, 1.0 mmol), tetrakis(triphenylphosphine)palladium(O) (115 mg, 0.10 mmol) and 4-tributyltinpyradine (439 mg, 1.2 mmol) were combined in DMF (2.0 mL) and purged with argon. The reaction mixture was heated to 200° C. for 45 minutes in a microwave reactor. Solids were filtered and resulting filtrate was diluted with dichloromethane (10 mL). Manganese(IV) oxide (2.2 g, 25 mmol) was then added as a single portion under ambient atmosphere and stirred for 1 hour at 25° C. at which point an addition portion of manganese(IV) oxide (2.2 g, 25 mmol) was added. After 1 hour of additional stirring the manganese(IV) oxide was removed via filtration through a pad of celite. The filtrate was concentrated then purified by via silica gel chromatography (eluent: EtOAc/hexanes) to give the product aldehyde. 
     Note: This protocol was employed successfully for other heteroaryl stannane coupling partners. 
     Synthesis of Selected Amines 
     
       
         
         
             
             
         
       
     
     (2,2-dimethylpropyl-1,1-d2)amine HCl 
     LiAlD 4  (252 mg, 6.02 mmol) was suspended in Et 2 O (10 mL) at room temperature. Trimethylacetonitrile (0.67 mL, 6.02 mmol) was then added slowly as a solution in Et 2 O (6 mL) keeping the temperature below reflux. After 30 minutes the reaction mixture was quenched by careful, slow addition of water until gas evolution ceased. Saturated aqueous Rochelle&#39;s salt solution (50 mL) was then added and the resulting solution stirred vigorously for 2 hours. The phases were then separated and the aqueous extracted with Et 2 O (3×30 mL). The combined organic phases were washed with brine (15 mL), dried over MgSO 4  and filtered. To the product solution in ether was added HCl (1.0M in ether, 15 mL, 15 mmol) after which the newly formed HCl salt was collected by filtration. 
     (R)-1-phenylpropan-1-amine-d7 
     
       
         
         
             
             
         
       
     
     Ellman Auxiliary Condensation: 
     (S)-(−)-2-methyl-2-propanesulfinamide (862 mg, 7.12 mmol) was dissolved in DCM (15 mL). PPTS (81 mg, 0.32 mmol), MgSO 4  (3.89 g, 32.3 mmol), and benzaldehyde-d were then added and the resulting mixture allowed to stir at room temperature for 4 hours. The reaction mixture was filtered through celite rinsing with DCM, concentrated and purified by flash chromatography (eluent: EtOAc/hexanes) to give the desired product. 
     Grignard Formation and Addition to Sulfinimine: 
     Ethylbromide-d5 (1.00 g, 8.77 mmol) as a solution in dry THF (2 mL) was added to a suspension of magnesium turnings (426 mg, 17.5 mmol) in dry THF (7 mL) and stirred at room temperature for 2 hours. Heat generation and discoloration indicate successful Grignard reagent formation to give an approximately 1.0M solution of EtMgBr-d5 in THF. EtMgBr-d5 (1.0M in THF, 7.2 mL, 7.2 mmol) was added dropwise to a solution of sulfinimine (752 mg, 3.58 mmol) in DCM (10 mL) at −78° C. After stirring for 3 hours at −78° C., the reaction mixture was allowed to warm to room temperature overnight. The reaction contents were quenched by the addition of saturated aqueous NH 4 Cl (5 mL), poured into water (5 mL) and extracted with EtOAc (3×30 mL). The combined organic phases were washed with brine (15 mL), dried over MgSO 4  and concentrated. The crude residue was purified by flash chromatography (eluent: EtOAc/hexanes) to give the desired product. 
     Auxiliary Removal: 
     Starting material (451 mg, 1.84 mmol) was dissolved in MeOH (0.9 mL) at room temperature. HCl (4.0M in dioxane, 0.92 mL, 3.69 mmol) was added and the solution stirred for 30 minutes. Reaction mixture was diluted with Et 2 O (20 mL) and the resulting precipitate collected by filtration to give the desired product as an HCl salt. 
     (1R,2R)-2-((S)-amino(phenyl)methyl)cyclopropanecarbonitrile 
     
       
         
         
             
             
         
       
     
     2-benzoylcyclopropanecarbonitrile 
     Phenacyl chloride (10.0 g, 64.7 mmol) and DABCO (7.26 g, 64.7 mmol) were dissolved in THF (200 mL) and DMSO (50 mL) at room temperature and stirred for 30 minutes. Na 2 CO 3  (10.3 g, 97.0 mmol) and acrylonitrile (8.48 mL, 129.4 mmol) were then added and the resulting mixture heated to 90° C. overnight. The reaction contents were quenched by the addition of saturated aqueous NH 4 Cl (40 mL), poured into water (20 mL) and extracted with EtOAc (3×150 mL). The combined organic phases were washed with brine (40 mL), dried over MgSO 4  and concentrated. The crude residue was purified by flash chromatography (eluent: EtOAc/hexanes) to give trans-2-benzoylcyclopropanecarbonitrile and cis-2-benzoylcyclopropanecarbonitrile separately and both as racemic mixtures. 
     (R)—N-(((1S,2S)-2-cyanocyclopropyl)(phenyl)methylene)-2-methylpropane-2-sulfinamide and (R)—N-(((1R,2R)-2-cyanocyclopropyl)(phenyl)methylene)-2-methylpropane-2-sulfinamide 
     Racemic trans-2-benzoylcyclopropanecarbonitrile (1.00 g, 5.84 mmol), (R)-(+)-2-methyl-2-propanesulfinamide (2.12 g, 17.5 mmol) and titanium(IV) ethoxide (7.35 mL, 35.1 mmol) were combined and heated to 85° C. for 3 hours. The reaction mixture was cooled to room temperature, diluted with EtOAc (100 mL) followed by water (5 mL) and allowed to stir for 30 minutes. The white precipitate was removed via filtration and the filtrate was washed with brine and concentrated. The crude residue was purified by flash chromatography (eluent: EtOAc/hexanes) to give (R)—N-(((1R,2R)-2-cyanocyclopropyl)(phenyl)methylene)-2-methylpropane-2-sulfinamide and (R)—N-(((1S,2S)-2-cyanocyclopropyl)(phenyl)methylene)-2-methylpropane-2-sulfinamide as pure enantiomers. 
     (R)—N—((S)-((1R,2R)-2-cyanocyclopropyl)(phenyl)methyl)-2-methylpropane-2-sulfinamide 
     (R)—N-(((1R,2R)-2-cyanocyclopropyl)(phenyl)methylene)-2-methylpropane-2-sulfinamide (250 mg, 0.91 mmol) was dissolved in THF and brought to −78° C. NaBH 4  (70.0 mg, 1.85 mmol) was added as a single portion and the reaction mixture allowed to warm slowly to room temperature. Upon reaching room temperature the reaction contents were quenched with water (2 mL) and extracted with EtOAc (3×8 mL). The combined organic phases were washed with brine (5 mL), dried over MgSO 4  and concentrated. The crude residue was purified by flash chromatography (eluent: EtOAc/hexanes) to give (R)—N—((R)-((1R,2R)-2-cyanocyclopropyl)(phenyl)methyl)-2-methylpropane-2-sulfinamide and (R)—N—((S)-((1R,2R)-2-cyanocyclopropyl)(phenyl)methyl)-2-methylpropane-2-sulfinamide as pure enantiomers. 
     (1R,2R)-2-((S)-amino(phenyl)methyl)cyclopropanecarbonitrile 
     (R)—N—((S)-((1R,2R)-2-cyanocyclopropyl)(phenyl)methyl)-2-methylpropane-2-sulfinamide (143 mg, 0.52 mmol) was dissolved in MeOH (0.5 mL) at room temperature. HCl (4.0M in dioxane, 0.26 mL, 1.04 mmol) was added and the solution stirred for 30 minutes. Reaction mixture was diluted with Et 2 O (20 mL) and the resulting precipitate collected by filtration to give the desired product as an HCl salt. 
     3-chloro-2-cyclopropoxyaniline 
     
       
         
         
             
             
         
       
     
     1-chloro-2-cyclopropoxy-3-nitrobenzene 
     To a solution of NaH (60% dispersion in mineral oil, 319 mg, 7.98 mmol) in THF (10 mL) was slowly added cyclopropyl alcohol (0.35 mL, 5.58 mmol). After 15 minutes of stirring, 1-chloro-2-fluoro-3-nitrobenzene (700 mg, 3.99 mmol) was added and the resulting solution heated to 75° C. for 1 hour. The reaction mixture was cooled to room temperature, quenched with water (5 mL) and extracted with EtOAc (3×15 mL). The combined organic phases were washed with brine (5 mL), dried over MgSO 4  and concentrated. The crude residue was purified by flash chromatography (eluent: EtOAc/hexanes) to give the desired product. 
     3-chloro-2-cyclopropoxyaniline 
     1-chloro-2-cyclopropoxy-3-nitrobenzene (420 mg, 1.97 mmol) was dissolved in EtOH (8 mL) at room temperature. Iron (549 mg, 9.83 mmol), CaCl 2  (327 mg, 2.95 mmol) and water (1 mL) were then added and the resulting mixture heated to 75° C. for 3 hours. The solids were removed by filtration washing with MeOH and EtOAc, the filtrate concentrated, and then redissolved in EtOAc (100 mL). The organic phase was washed with saturated aqueous NaHCO 3  (2×20 mL), brine (20 mL), dried over MgSO 4  and concentrated to give the crude product which was used without further purification. 
     Diazotransfer Reaction and Generation of Azides 
     
       
         
         
             
             
         
       
     
     Glycinamide hydrochloride (50 mg, 0.45 mmol) was added to a suspension of 1H-imidazole-1-sulfonyl azide hydrochloride (118.5 mg, 0.56 mmol), potassium carbonate (125 mg, 0.90 mmol), and copper (II) sulfate pentahydrate (11.2 mg, 0.045 mmol) in methanol (1.0 mL). The blue mixture was stirred at room temperature for 16 hrs and was used without workup in the Click chemistry (Procedure 4). Reference: E. D. Goddard, et. al., Org. Lett., 2007, p. 3797. 
     Piperidine-Triazole Aldehyde 
     
       
         
         
             
             
         
       
     
     Benzyl 4-(tosyloxy)piperidine-1-carboxylate (2) 
     Benzyl 4-hydroxypiperidine-1-carboxylate (1) (17.2 g, 73.1 mmol) and p-toluenesulfonyl chloride (15.3 g, 80.4 mmol) were dissolved in pyridine (50 mL) and stirred at room temperature. After 23 hrs, the pyridine was removed under reduced pressure and the residue was dissolved in EtOAc (300 mL). The organic phase was washed with water (2×150 mL) and saturated ammonium chloride (100 mL), dried over sodium sulfate and the solvent was removed under reduced pressure. The residue was subjected to flash chromatography (eluent: ethyl acetate/hexanes). The fractions containing product were combined and the solvent was removed under reduced pressure, providing benzyl 4-(tosyloxy)piperidine-1-carboxylate (2). 
     Benzyl 4-azidopiperidine-1-carboxylate (3) 
     Sodium azide (2.48 g, 38.2 mmol) was added to a solution of benzyl 4-(tosyloxy)piperidine-1-carboxylate (2) (12.4 g, 31.8 mmol) in dimethylformamide (100 mL). The mixture was heated at 90° C. for 30 minutes. The mixture was cooled and diluted with ethyl acetate (250 mL) and washed with water (2×15 mL), 5% aqueous lithium chloride (10 mL) and brine (10 mL). The organic phase was dried over sodium sulfate and concentrated (not to dryness) providing the desired material. The yield was assumed to 100% and all material was used in the next step. 
     Benzyl 4-(4-(diethoxymethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate (4) 
     Copper powder (2.0 g, 31.5 mmol), was added to a solution of benzyl 4-azidopiperidine-1-carboxylate (3) (8.2 g, 31.5 mmol) 3,3-diethoxyprop-1-yne (4.44 g, 34.6 mmol) and saturated copper (II) sulfate (8 mL) in tetrahydrofuran (100 mL). After 17 hrs, the mixture was filtered through a pad of celite. The solvent was removed under reduced pressure and the residue was taken up in ethyl acetate (200 mL). The organic phase was washed with brine (3×100 mL), dried over sodium sulfate and concentrated. The residue was subjected to flash chromatography on silica gel (eluent: ethyl acetate/hexanes). The fractions containing product were combined and the solvent was removed under reduced pressure providing benzyl 4-(4-(diethoxymethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate (4). 
     Benzyl 4-(4-formyl-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate (5) 
     Aqueous hydrochloric acid (1 M, 2.2 mL, 2.2 mmol) was added to a solution of benzyl 4-(4-(diethoxymethyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate (4) (429 mg, 1.1 mmol) in tetrahydrofuran (4 mL) and water (2 mL). The organic solvent was removed under reduced pressure. The aqueous mixture was diluted with acetonitrile (2 mL) and subjected to lyophilization. The yield was assumed to be 100%. 
     COMPOUND EXAMPLES 
     Example 1 Procedure 1 
     
       
         
         
             
             
         
       
     
     8-chloro-4-(neopentylamino)-6-nitroquinoline-3-carbonitrile 
     4,8-dichloro-6-nitroquinoline-3-carbonitrile (615 mg, 2.29 mmol), neopentylamine (220 mg, 0.25 mmol) and triethylamine (278 mg, 2.75 mmol) in iso-propanol (4 mL) were heated under microwave conditions at 150° C. for 45 minutes. The reaction was cooled to room temperature. Water was added and the resulting precipitate was collected via filtration. The crude product was used in the next step without further purification. 
     ES/MS (M+H + ) 319.1. 
     Alternative Reaction Conditions for this Transformation: 
     4,8-dichloro-6-nitroquinoline-3-carbonitrile (3000 mg, 11.2 mmol), neopentylamine (1073 mg, 12.3 mmol) and triethylamine (1246 mg, 12.3 mmol) in iso-propanol (60 mL) were heated at 80° C. for 4 hrs. The reaction was cooled to room temperature. Removed the solvents and purified the crude reaction product via chromatography on silica gel (eluent: EtOAc/hexanes) yielding the product. 
     ES/MS (M+H + ) 319.1. 
     6-amino-8-chloro-4-(neopentylamino)quinoline-3-carbonitrile 
     8-chloro-4-(neopentylamino)-6-nitroquinoline-3-carbonitrile (699 mg, 2.2 mmol), calcium chloride (483.6 mg, 3.28 mmol), iron powder (612.3 mg, 10.96 mmol) were heated in ethanol (22 mL)/water (2.2 mL) at 60° C. for 1 hour. The reaction was cooled to room temperature and solids were removed via filtration. The solids were washed with EtOAc and the combined organic layers were washed with aqueous sodium bicarbonate solution, brine, and were dried over sodium sulfate. Filtration and evaporation of all volatiles yielded the product. 
     ES/MS 289.1 (M+H + ). 
     Alternative Reduction Conditions with Tin Chloride: 
     8-chloro-4-(neopentylamino)-6-nitroquinoline-3-carbonitrile (2,000 mg, 6.2 mmol) and tin chloride (7079 mg, 31.3 mmol) heated at 70° C. for 4 hrs at which point more tin chloride (2832 mg, 12.6 mmol) was added. After 5 hrs, the reaction was complete. The reaction was cooled to room temperature. Half of the ethanol was removed under reduced pressure. The mixture was added to NaHCO 3  (200 mL) and diluted with EtOAc (500 mL). The organic phase was washed with brine (200 mL) and dried over sodium sulfate. The solvent was removed under reduced pressure, providing the desired material crude. 
     1H NMR (400 MHz, DMSO-d6) δ 8.19 (s, 1H), 7.32 (d, J=2.1 Hz, 1H), 7.29 (t, J=7.3 Hz, 1H), 7.18 (d, J=2.3 Hz, 1H), 5.74 (s, 2H), 3.66 (d, J=6.6 Hz, 2H), 0.96 (s, 9H). 
     ES/MS 289.1 (M+H + ). 
     (S)-8-chloro-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)-methyl-d)amino)-4-(neopentylamino)quinoline-3-carbonitrile 
     6-amino-8-chloro-4-(neopentylamino)quinoline-3-carbonitrile (75 mg, 0.26 mmol), CuI (5 mg, 0.026 mmol) and 2,6-bis((4S,5R)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine [oxazoline ligand] (13.6 mg, 0.026 mmol) were sonicated in MeOH (3.5 mL) for about 1 minute. Alkynyl acetate (60.2 mg, 0.31 mmol) and di-isopropyl ethyl amine (40.3 mg, 0.31 mmol) were added and the reaction was stirred overnight. Cyclopropylazide (26 mg, 0.31 mmol) was added and the reaction was stirred or additional 2 hrs at room temperature. Solvents were removed in vacuo and the crude material was purified via silica gel chromatography (eluent: EtOAc/hexanes) and RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
     1H NMR (400 MHz, DMSO-d6) δ 8.34 (d, J=1.2 Hz, 1H), 8.01 (s, 1H), 7.72 (s, 1H), 7.59 (d, J=2.2 Hz, 1H), 7.52 (m, 2H), 7.40 (s, 1H), 7.12 (m, 4H), 3.96 (m, 2H), 3.46 (dd, J=13.9/5.5 Hz, 1H), 1.11 (m, 4H), 0.88 (s, 9H). ES/MS 505.3 (M+H + ). 
     Example 2 Procedure 2 
     
       
         
         
             
             
         
       
     
     (R)-8-chloro-6-nitro-4-((1-phenylpropyl)amino)quinoline-3-carbonitrile 
     4,8-dichloro-6-nitroquinoline-3-carbonitrile (200 mg, 0.75 mmol), (R)-ethyl benzylamine (121 mg, 0.895 mmol) in iso-propanol (3 mL) were heated under microwave conditions at 150° C. for 45 minutes. The reaction was cooled to room temperature. Water and EtOAc were added. The aqueous layer was extracted with EtOAc and the combined organic layers were dried over sodium sulfate. Filtration and evaporation of solvents yielded the crude product which was used in the next step without further purification. 
     ES/MS 367.1 (M+H + ). 
     6-amino-8-chloro-4-((1-phenylpropyl)amino)quinoline-3-carbonitrile 
     (R)-6-amino-8-chloro-4-((1-phenylpropyl)amino)quinoline-3-carbonitrile (287 mg, 0.78 mmol), calcium chloride (172.6 mg, 1.17 mmol), iron powder (218.5 mg, 3.91 mmol) were heated in ethanol (5 mL)/water (0.5 mL) at 60° C. for 1 hour. The reaction was cooled to room temperature and solids were removed via filtration. The solids were washed with EtOAc and the combined organic layers were washed with aqueous sodium bicarbonate solution, brine, and were dried over sodium sulfate. Filtration and evaporation of all volatiles yielded the product. 
     ES/MS 337.1 (M+H + ). 
     (S)-8-chloro-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)-methyl-d)amino)-4-((1-phenylpropyl)amino)quinoline-3-carbonitrile 
     ((R)-6-amino-8-chloro-4-((1-phenylpropyl)amino)quinoline-3-carbonitrile (55 mg, 0.16 mmol), CuI (3.1 mg, 0.016 mmol) and 2,6-bis((4S,5R)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine [oxazoline ligand] (8.5 mg, 0.016 mmol) were sonicated in MeOH (2.0 mL) for about 1 minute. Alkynyl acetate (34.1 mg, 0.18 mmol) and di-isopropyl ethyl amine (25.3 mg, 0.2 mmol) were added and the reaction was stirred overnight. Cyclopropylazide (17 mg, 0.2 mmol) in MeOH (1 mL) was added and the reaction was stirred for additional 24 hrs at room temperature. Solvents were removed in vacuo and the crude material was purified RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
       1 H NMR (400 MHz, DMSO-d 6 ) δ 8.26 (s, 1H), 8.03 (s, 1H), 7.62-7.51 (m, 3H), 7.45-7.29 (m, 3H), 7.29-7.20 (m, 4H), 7.20-7.12 (m, 2H), 5.52-5.36 (m, 1H), 4.00-3.94 (m, 1H), 2.19-2.09 (m, 1H), 1.98-1.89 (m, 1H), 1.19-1.12 (m, 2H), 1.13-1.06 (m, 2H), 0.99-0.88 (m, 3H). 
     ES/MS 553.2 (M+H + ). 
     Example 3 Procedure 3 
     
       
         
         
             
             
         
       
     
     (S)-8-chloro-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)-methyl)amino)-4-(neopentyl)quinoline-3-carbonitrile 
     CuI (2.0 mg, 0.01 mmol) and 2,6-bis((4S,5R)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine [oxazoline ligand] (6.5 mg, 0.012 mmol) were sonicated in MeOH (5.0 mL) for about 5 minutes. Alkynyl acetate (23.5 mg, 0.13 mmol) in MeOH (2 mL), 6-amino-8-chloro-4-(neopentylamino)quinoline-3-carbonitrile (30 mg, 0.104 mmol), and di-isopropyl ethyl amine (16.1 mg, 0.13 mmol) were added and the reaction was stirred for 1 hour. The crude reaction product was filtered over silica gel (eluent: EtOAc/hexanes) and this product was used in the next step. 
     ES/MS 417.3 (M+H + ). 
     The product from the N-alkylation was dissolved in THF (1 mL) at room temperature and copper (I) thiophene carboxylate (7.8 mg, 0.041 mmol) was added. Cyclopropylazide (8.5 mg, 0.014 mmol) in THF (1 mL) was added and the reaction was stirred for 30 minutes at room temperature. The reaction was partitioned between aqueous sodium bicarbonate solution and EtOAc. The aqueous layer was extracted with EtOAc and the combined layers were washed with brine and dried over sodium sulfate. Filtration and evaporation of solvents gives crude material. The crude material was purified RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
       1 H NMR (400 MHz, Methanol-d 4 ) δ 8.48 (s, 1H), 7.75 (s, 1H), 7.61 (s, 1H), 7.28-7.13 (m, 4H), 6.90 (s, 1H), 6.17 (s, 1H), 3.99 (d, J=13.8 Hz, 1H), 3.92-3.83 (m, 2H), 2.38 (s, 3H), 1.25-1.08 (m, 4H), 0.94 (s, 9H). 
     ES/MS 500.2 (M+H + ). 
     Example 4 Procedure 4 
     
       
         
         
             
             
         
       
     
     (S)-2-(4-(((8-chloro-3-cyano-4-(neopentylamino)quinolin-6-yl)amino)(2-chlorophenyl) methyl-d)-1H-1,2,3-triazol-1-yl)acetamide 
     2-Deutero (R)-8-chloro-6-((1-(2-chlorophenyl)prop-2-yn-1-yl)amino)-4-(neopentylamino)quinoline-3-carbonitrile (20 mg, 0.046 mmol), copper powder (15 mg, 0.23 mmol), acetic acid (108 μL, 1.8 mmol) and saturated aqueous copper (II) sulfate (0.1 mL) were added to the stock solution of 2-azidoacetamide (45 mg, 0.045 mmol). After 2 hrs, the reaction was complete. The solids were removed by filtration. The solution was diluted with ethyl acetate (15 mL) and washed with saturated sodium bicarbonate (8 mL), brine (8 mL), dried over Na 2 SO 4  and concentrated. The residue was taken up in water (1 mL) and MeOH (1 mL) with 2 drops of TFA and subjected to RP-HPLC (eluent: water/MeCN*0.1% TFA). The fractions containing the desired product were combined and subjected to lyophilization, providing the desired compound. 
       1 H NMR (400 MHz, Methanol-d4) δ 8.52 (s, 1H), 7.83 (s, 1H), 7.63 (t, J=1.5 Hz, 1H), 7.50 (d, J=7.3 Hz, 2H), 7.40-7.30 (m, 2H), 7.02 (d, J=2.3 Hz, 1H), 5.25-5.12 (m, 2H), 4.11 (d, J=13.8 Hz, 1H), 3.84 (d, J=13.8 Hz, 1H), 1.00 (s, 9H). 
     Example 5 Procedure 5 
     
       
         
         
             
             
         
       
     
     (R)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-((1-(4-fluorophenyl)prop-2-yn-1-yl)amino)quinoline-3-carbonitrile 
     CuI (27.0 mg, 0.144 mmol) and 2,6-bis((4S,5R)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine [oxazoline ligand] (90.1 mg, 3.46 mmol) were sonicated in MeOH (10 mL) for about 5 minutes. Additional MeOH (40 mL) was added. Alkynyl acetate (23.5 mg, 0.13 mmol) in MeOH (2 mL), 6-amino-8-chloro-4-((4-chloro-3-fluorophenyl)amino)quinoline-3-carbonitrile (1000 mg, 2.88 mmol), and di-isopropyl ethyl amine (484 mg, 3.75 mmol) were added and the reaction was stirred at −15° C. for 23 hour. The crude reaction product was purified via silica gel chromatography (eluent: EtOAc/hexanes) to yield the product. 
       1 H NMR (400 MHz, DMSO-d6) δ 9.42 (s, 1H), 8.42 (d, J=0.9 Hz, 1H), 7.65-7.56 (m, 4H), 7.53 (dt, J=6.6, 1.9 Hz, 1H), 7.48-7.39 (m, 3H), 7.32-7.26 (m, 2H), 7.26-7.20 (m, 3H), 7.18 (d, J=9.0 Hz, 1H), 5.64 (dd, J=9.1, 2.3 Hz, 1H), 3.49 (d, J=2.2 Hz, 1H). 
     ES/MS 479.2 (M+H + ). 
     (S)-benzyl 4-(4-(((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)(4-fluorophenyl)methyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate 
     (R)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-((1-(4-fluorophenyl)prop-2-yn-1-yl)amino)quinoline-3-carbonitrile (1000 mg, 2.086 mmol) and N-Cbz piperidine 4 azide (543 mg, 2.086 mmol) were dissolved in THF (20 mL). Copper metal (132 mg, 2.086 mmol) was added followed by saturated aqueous copper sulfate solution (1 mL). After 16 hrs, the reaction was complete. The solids were removed by filtration through a pad of celite. The volatiles were removed under reduced pressure and the residue was purified by chromatography on silica gel (eluent: EtOAc/hexanes). The fractions containing product were combined and the solvent was removed under reduced pressure, providing the product. 
     ES/MS 739.1 (M+H + ). 
     Alternatively, the cycloaddition can be performed with Cu(I)thiophenecarboxylate catalyst or using the Cu(I) present from the N-alkylation. 
     Increase of the ee via recrystallization: 1.08 g of (S)-benzyl 4-(4-(((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)(4-fluorophenyl)methyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate (83% ee) was dissolved in THF (15 mL). The solvent was removed under reduced pressure. The residue was stirred with EtOH (30 mL). A fine solid formed and was isolated by filtration. Repeated the cycle two more time, providing the title compound with &gt;95% ee. 
     (S)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-(((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl)amino)quinoline-3-carbonitrile 
     (S)-benzyl 4-(4-(((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)(4-fluorophenyl)methyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate (130 mg, 0.176 mmol) was dissolved in EtOAc (12 mL). Pd—C(37.3 mg; 10%) was added and the atmosphere was replaced with hydrogen. Acetaldehyde (77.4 mg, 1.75 mmol) was added and the reaction was stirred for 2.5 hrs at room temperature. The Pd/C was removed by filtration and the solvent was removed under reduced pressure. The residue was subjected to flash chromatography (eluent: (20% MeOH in EtOAc)/hexanes). The fractions containing product were combined and the solvent was removed under reduced pressure. The residue was taken up in DMF (0.4 ml) and MeOH (2 mL) with 2 drops of TFA and subjected to RP-HPLC (eluent: water/MeCN*0.1 TFA). The product fractions were combined and lyophilized, providing the product as trifluoro actetate salt. 
       1 H NMR (400 MHz, DMSO-d6) δ 9.40 (s, 1H), 9.31 (s, 1H), 8.40 (s, 1H), 8.11 (s, OH), 7.98 (s, 1H), 7.66 (d, J=2.2 Hz, 1H), 7.51-7.43 (m, 4H), 7.42-7.32 (m, 2H), 7.21 (qd, J=4.3, 2.7 Hz, 3H), 7.14 (t, J=8.8 Hz, 3H), 6.14-6.01 (m, 1H), 4.85 (d, J=7.6 Hz, 0H), 4.72 (ddd, J=11.8, 7.7, 4.1 Hz, 1H), 3.60 (d, J=13.7 Hz, 4H), 3.41 (m, OH), 3.25-3.10 (m, 3H), 3.06 (dt, J=13.3, 10.2 Hz, 1H), 2.41-2.25 (m, 2H), 2.24-2.07 (m, 2H), 1.22 (t, J=7.3 Hz, 3H). 
     ES/MS 633.1 (M+H + ). 
     Removal of the protecting group in the absence of a reaction partner yields the corresponding un-alkylated amine derivatives. 
     Example 6 Procedure 6 
     
       
         
         
             
             
         
       
     
     Benzyl 4-(4-(((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)(4-chlorophenyl)methyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate 
     A suspension of the 6-amino-8-chloro-4-((4-chloro-3-fluorophenyl)amino)quinoline-3-carbonitrile (204 mg, 0.65 mmol), aldehyde (225 mg, 0.65 mmol) and pTSA (12.4 mg, 0.065 mmol) in toluene (15 mL) was heated at reflux (50 mL RBF equipped with a Hickman still). After 4 hrs, the solvent was removed under reduced pressure. The solid was dissolved in methyl-THF and 4-Cl-phenylmagnesium bromide (2.6 mmol; 2.6 mL 1-M THF) was added dropwise at −10 C. After 30 min, the reaction was quenched with sat NH 4 Cl (3 mL). The layers were separated and the aqueous phase was extracted with EtOAc (15 mL). The combined organic layers were washed with brine (5 mL), dried over sodium sulfate and concentrated. The residue was subjected to flash chromatography on silica gel (eluent: EtOAc/hexanes). The fractions containing product were combined and the solvent was removed providing the product. 
     ES/MS 753.5 (M+H + ). 
     8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-(((4-chlorophenyl)(1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)amino)quinoline-3-carbonitrile 
     The starting material (94 mg, 0.124 mmol) and Pd—C(39 mg, 10%) in EtOH (3 mL)/EtOAc (2 mL) were stirred under an atmosphere of hydrogen. After 18 hrs, the reaction was filtered and the volatiles were removed in vacuo and the crude was purified via RP-HPLC (eluent: water/MeCN 0.1% TFA) to yield the product as trifluoro acetate salt. 
     1H NMR (400 MHz, DMSO-d6) δ 9.42-9.32 (m, 2H), 8.40 (s, 1H), 8.13 (s) &amp; 8.00 (s, 1H), 7.66 (d, J=2.2 Hz, 1H), 7.48-7.20 (m, 13H), 6.07 (m, 1H), 4.84 (m) &amp; 4.73 (m, 1H), 3.67-3.56 (m, 3H), 3.25-2.98 (m, 6H), 2.42-2.25 (m, 2H), 2.24-2.08 (m, 2H), 1.21 (t, J=7.3 Hz, 3H). 
     ES/MS 648. (M+H + ). 
     Removal of the protecting group in the absence of a reaction partner yields the corresponding un-alkylated amine derivatives. 
     Example 7 Procedure 7 
     
       
         
         
             
             
         
       
     
     8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-(((4-fluorophenyl)(isoxazol-3-yl)methyl)amino)quinoline-3-carbonitrile 
     To a suspension of the 6-amino-8-chloro-4-((4-chloro-3-fluorophenyl)amino)quinoline-3-carbonitrile (50 mg, 0.144 mmol) and (4-fluorophenyl)(isoxazol-3-yl)methanone (28 mg, 0.144 mmol) in DCM (2 mL) was added triethylamine (35 mg, 0144 mmol) followed by TiCl 4  in DCM (0.86 mmol/0.086 mL). The reaction was stirred overnight at room temperature. It was diluted with MeOH (2 mL) and sodium borohydride (16 mg, 0.43 mmol) was added. The reaction was stirred for 2 hours, then was diluted with water and treated with 1M NaOH until a pH of about 13 was reached. It was extracted with DCM three times, and the combined organic layers were dried over sodium sulfate, filtered, and concentrated. The product was purified by chromatography on silica gel (eluent: EtOAc/hexanes) to yield the material as an oil, which was lyophilized from MeCN/water to yield the product as a solid. 
     1H NMR (400 MHz, DMSO-d6) δ 9.44 (s, 1H), 8.89 (dd, J=1.7, 0.5 Hz, 1H), 8.42 (s, 1H), 7.69 (d, J=2.3 Hz, 1H), 7.58-7.41 (m, 5H), 7.34 (d, J=2.4 Hz, 1H), 7.27 (ddd, J=8.9, 4.2, 2.7 Hz, 1H), 7.25-7.17 (m, 2H), 6.62 (d, J=1.7 Hz, 1H), 6.21 (d, J=9.4 Hz, 1H). 
     ES/MS 522.1 (M+H + ). 
     Example 8 Procedure 8 
     
       
         
         
             
             
         
       
     
     (4-fluorophenyl)(1-methyl-1H-1,2,3-triazol-4-yl)methanol 
     1.0 M (THF) of (4-fluorophenyl)magnesium bromide (4.9 mL, 4.9 mmol) was added to a stirring solution of 1-methyl-1H-1,2,3-triazole-4-carbaldehyde (500 mg, 4.5 mmol) in THF (30 mL) at 0° C. The resulting solution was allowed to warm to room temperature then stirred for additional 16 hrs. The reaction mixture was quenched with satd. aqueous NH 4 Cl (30 mL) and the aqueous layer was extracted with EtOAc (3×30 mL). The combined organic layer was washed with brine, dried over Na 2 SO 4 , and concentrated to give crude alcohol. Chromatography afforded the title compound. ES/MS 208.0 (M+H + ). 
     4-(chloro(4-fluorophenyl)methyl)-1-methyl-1H-1,2,3-triazole 
     SOCl 2  (0.9 mL, 12 mmol) was added to a stirring solution of (4-fluorophenyl)(1-methyl-1H-1,2,3-triazol-4-yl)methanol (520 mg, 2.5 mmol) in DCM (50 mL). The reaction mixture was stirred for 16 hrs then concentrated to give crude chloride. The resulting compound was used in the next step with no further purification. 
     8-bromo-4-((3-chloro-4-fluorophenyl)amino)-6-(((4-fluorophenyl)(1-methyl-1H-1,2,3-triazol-4-yl)methyl)amino)quinoline-3-carbonitrile 
     4-(chloro(4-fluorophenyl)methyl)-1-methyl-1H-1,2,3-triazole (86 mg, 0.38 mmol) and di-isopropyl ethyl amine (0.2 mL, 1.28 mmol) were added to a stirring solution of 6-amino-8-bromo-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile (100 mg, 0.25 mmol) in ACN (10 mL). The reaction mixture was heated at 90° C. for 16 hrs. The solution was cooled to room temperature then concentrated to give crude product. RP-HPLC (eluent: water/MeCN*0.1% TFA) afforded the title compound. 
       1 H NMR (400 MHz, DMSO-d6) δ 9.85 (s, 1H), 9.42 (s, 1H), 8.38 (s, 1H), 7.88-7.81 (m, 2H), 7.57-7.31 (m, 5H), 7.28-7.06 (m, 3H), 6.05 (s, 1H), 3.97 (s, 3H). 
     ES/MS 580.1 (M+H + ). 
     Example 9 Procedure 9 
     
       
         
         
             
             
         
       
     
     (S)—N-(3-((1-cyclopropyl-1H-1,2,3-triazol-4-yl)((3,8-dicyano-4-(neopentylamino)quinolin-6-yl)amino)methyl)phenyl)-N-methylacetamide 
     DMF (2 mL) was added to (S)—N-(3-(((8-bromo-3-cyano-4-(neopentylamino)quinolin-6-yl)amino)(1-cyclopropyl-1H-1,2,3-triazol-4-yl)methyl)phenyl)-N-methylacetamide (92 mg, 0.15 mmol) and CuCN (41 mg, 0.46 mmol) in a microwave vial. The vial was heated to 200° C. for 15 minutes in a microwave and allowed to cool to room temperature. The reaction mixture was poured into water (4 mL) and extracted with EtOAc (3×8 mL). The combined organic phases were washed with brine (5 mL), dried over MgSO 4  and concentrated. The crude residue was purified by RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
     ES/MS 548.1 (M+H + ). 
     Alternative Access to the 8-Cyano Core 
     
       
         
         
             
             
         
       
     
     6-amino-4-(neopentylamino)quinoline-3,8-dicarbonitrile 
     Solid Zn(CN) 2  (211 mg, 1.8 mmol) and Pd(PPh) 4  (35 mg, 0.03 mmol) were added to a solution of 6-amino-8-bromo-4-(neopentylamino)quinoline-3-carbonitrile (500 mg, 1.5 mmol) in NMP (20 mL). The resulting mixture was degassed by bubbling argon gas through for 5 min. The reaction vessel was sealed then heated to 120° C. for 16 hrs. The reaction mixture was cooled then loaded directly to silica column to afford the pure nitrile. ES/MS 280.3 (M+H + ). 
     Further elaboration to the final compound can be performed according to procedures outlined herein. 
     Example 10 Procedure 10 
     
       
         
         
             
             
         
       
     
     8-chloro-4-((5-chloro-6-fluoropyridin-3-yl)amino)-6-nitroquinoline-3-carbonitrile 
     4,8-dichloro-6-nitroquinoline-3-carbonitrile (300 mg, 1.12 mmol), 5-chloro-6-fluoropyridin-3-amine (180 mg, 1.23 mmol) and pyridine hydrochloride (388 mg, 3.36 mmol) in iso-propanol (7 mL) was heated at 60° C. overnight. The reaction was cooled to room temperature. Water was added and the resulting precipitate was collected via filtration. The crude product was used in the next step without further purification. 
     ES/MS 377.9 (M+H + ). 
     6-amino-8-chloro-4-((5-chloro-6-fluoropyridin-3-yl)amino)quinoline-3-carbonitrile 
     8-chloro-4-((5-chloro-6-fluoropyridin-3-yl)amino)-6-nitroquinoline-3-carbonitrile (405 mg, 1.07 mmol), calcium chloride (178 mg, 1.61 mmol), iron powder (179 mg, 3.21 mmol) were heated in ethanol (10 mL)/water (1 mL) at 60° C. overnight. The reaction was cooled to room temperature and solids were removed via filtration. The solids were washed with EtOAc and the combined organic layers were washed with aqueous sodium bicarbonate solution, brine, and were dried over sodium sulfate. Filtration and evaporation of all volatiles yielded the crude product. ES/MS 348.0 (M+H + ). 
     (S)-6-(((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(phenyl)methyl)amino)-8-chloro-4-((5-chloro-6-fluoropyridin-3-yl)amino)quinoline-3-carbonitrile 
     6-amino-8-chloro-4-((5-chloro-6-fluoropyridin-3-yl)amino)quinoline-3-carbonitrile (242 mg, 0.69 mmol), CuI (13 mg, 0.07 mmol) and 2,6-bis((4S,5R)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine [oxazoline ligand] (36 mg, 0.07 mmol) were sonicated in MeOH (9 mL) for about 1 minute. Alkynyl acetate (145 mg, 0.83 mmol) and di-isopropyl ethyl amine (108 mg, 0.83 mmol) were added and the reaction was stirred overnight. 4-azido-1-(tert-butyl)piperidine (152 mg, 0.83 mmol) was added and the reaction was stirred for two days at room temperature. Solvents were removed in vacuo and the crude material was purified via silica gel chromatography (eluent: EtOAc/hexanes) and RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as the trifluoroacetate salt. 
       1 H NMR (400 MHz, DMSO-d 6 ) δ 9.61 (s, 1H), 9.22 (m, 1H), 8.46 (s, 1H), 8.18-8.09 (m, 2H), 7.99 (s, 1H), 7.72 (d, J=2.2 Hz, 1H), 7.53-7.42 (m, 3H), 7.38-7.19 (m, 4H), 6.12-6.04 (m, 1H), 4.87-4.73 (m, 1H), 3.65 (d, J=11.7 Hz, 2H), 3.12 (dt, J=13.1, 10.2 Hz, 2H), 2.43-2.17 (m, 4H), 1.36 (s, 9H). ES/MS 644.2 (M+H + ). 
     Example 11 Procedure 11 
     
       
         
         
             
             
         
       
     
     (S)-8-acetyl-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-4-(neopentylamino)quinoline-3-carbonitrile 
     To (S)-8-bromo-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-4-(neopentylamino)quinoline-3-carbonitrile (85 mg, 0.16 mmol) in DMF (1 mL) and water (0.1 mL) was added 4-(vinyloxy)butan-1-ol (72 mg, 0.62 mmol), palladium (II) acetate (1 mg, 0.005 mmol), 1,3-bis(diphenylphosphino)propane (3 mg, 0.009 mmol) and potassium carbonate (32 mg, 0.23 mmol). Reaction mixture was flushed with nitrogen and then heated at 100° C. overnight. After cooling to room temperature, 1N HCl (1 mL) was added and the mixture stirred for 10 hours. Reaction was diluted with water and extracted thrice with EtOAc. Combined organics were washed with water and brine and dried (Na 2 SO 4 ). Filtrate was concentrated to yield the crude title compound material which was purified by HPLC (eluent: water/MeCN*0.1% TFA). Product was obtained as a solid. 
     ES/MS 513.3 (M+H + ). 
     Example 12 Procedure 12 
     
       
         
         
             
             
         
       
     
     (S)-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-4-(neopentylamino)-8-(pyrimidin-5-yl)quinoline-3-carbonitrile 
     To (S)-8-bromo-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-4-(neopentylamino)quinoline-3-carbonitrile (35 mg, 0.06 mmol), pyrimidin-5-ylboronic acid (9 mg, 0.08 mmol) and [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane (2 mg, 0.003 mmol) was added dioxane (0.5 mL) and 1.5 M aqueous cesium carbonate (0.13 mL). Reaction mixture was flushed with nitrogen and heated at 80° C. overnight. Reaction was diluted with water and extracted twice with EtOAc. Combined organics were washed with water, brine, dried (Na 2 SO 4 ), filtered and concentrated. Crude material was purified by HPLC (eluent: water/MeCN*0.1% TFA) to yield the product. ES/MS 549.3 (M+H + ). 
     Example 13 Procedure 13 
     
       
         
         
             
             
         
       
     
     (S)-8-bromo-6-(((1-cyclopropyl-5-(methylthio)-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-4-(neopentylamino)quinoline-3-carbonitrile 
     To (S)-8-bromo-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-4-(neopentylamino)quinoline-3-carbonitrile (55 mg, 0.10 mmol) in THF (1 mL) at −78° C. was added, under nitrogen atmosphere, n-butyllithium (0.2 mL, 1.6 M). The mixture was stirred for 15 minutes after which a solution of dimethyldisulfide (11 mg, 0.12 mmol) in THF (0.5 mL) was added drop wise. The reaction mixture was allowed to warm to room temperature overnight and carefully quenched with water. Product was extracted with EtOAc and combined organics were washed with water, brine and dried (Na 2 SO 4 ). Filtration and removal of solvent in vacuo furnished the crude which was purified by HPLC (eluent: water/MeCN*0.1% TFA) to give the product as a solid. 
       1 H NMR (400 MHz, DMSO-d 6 ) δ 8.33 (s, 1H), 7.88 (d, J=2.1 Hz, 1H), 7.73 (s, 1H), 7.58-7.50 (m, 2H), 7.39 (s, 1H), 7.15-7.07 (m, 3H), 4.03 (dd, J=13.9, 8.1 Hz, 1H), 3.98-3.88 (m, 1H), 3.41 (dd, J=13.9, 5.3 Hz, 1H), 2.26 (d, J=0.5 Hz, 3H), 1.28-1.14 (m, 4H), 0.85 (s, 9H). 
     ES/MS 595.2 (M+H + ). 
     Example 14 Procedure 14 
     
       
         
         
             
             
         
       
     
     (S)-8-acetyl-6-(((2-chlorophenyl)(1-cyclopropyl-1H-1,2,3-triazol-4-yl)methyl-d)amino)-4-(neopentylamino)quinoline-3-carbonitrile 
     To (S)-8-bromo-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-4-(neopentylamino)quinoline-3-carbonitrile (65 mg, 0.12 mmol) and bis(triphenylphosphine)palladium(II) dichloride (8 mg, 0.01 mmol) in toluene (1 mL) was added tributyl(2-ethoxyallyl)stannane (47 mg, 0.13 mmol). The reaction mixture was flushed with nitrogen and heated at 100° C. overnight. After cooling to room temperature, 2N HCl (1 mL) was added and the mixture stirred for 2 hours. Reaction was diluted with water and extracted thrice with EtOAc. Combined organics were washed with water and brine and dried (Na 2 SO 4 ). Filtrate was concentrated to yield the crude material which was purified twice by HPLC (eluent: water/MeCN*0.1% TFA) to give the product. ES/MS 529.2 (M+H + ). 
     Example 15 Procedure 15 
     
       
         
         
             
             
         
       
     
     8-chloro-6-(((S)-(3-cyanophenyl)(1H-1,2,3-triazol-4-yl)methyl-d)amino)-4-(((R)-1-phenylpropyl)amino)quinoline-3-carbonitrile 
     Starting alkyne (133 mg, 0.28 mmol) was dissolved in THF (2 mL). Cu(I)-thiophene-2-carboxylate (11 mg, 0.084 mmol) and azidomethyloxy pivalate (0.056 mL, 0.36 mmol) were added and the resulting solution stirred at room temperature for 30 minutes. The reaction contents were poured into saturated aqueous NaHCO 3  solution (5 mL) and extracted with EtOAc (3×8 mL). The combined organic layers were washed with brine (5 mL), dried over MgSO 4  and concentrated. The resulting crude residue was then dissolved in MeOH (2 mL). NaOH (1.0M in water, 0.61 mL, 0.61 mmol) was added and the reaction allowed to stir at room temperature for 30 min. HCl (1.0M in water, 0.61 mL, 0.61 mmol) was then added, the resulting solution poured into water (5 mL) and extracted with EtOAc (3×15 mL). The combined organic layers were washed with brine (5 mL), dried over MgSO 4  and concentrated. The resulting crude residue was purified by RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
     ES/MS 520.0 (M+H + ). 
     Example 16 Procedure 16 
     
       
         
         
             
             
         
       
     
     N-(8-chloro-3-cyano-6-nitroquinolin-4-yl)benzamide 
     To 4,8-dichloro-6-nitroquinoline-3-carbonitrile (300 mg, 1.12 mmol), benzamide (163 mg, 1.34 mmol), tris(dibenzylideneacetone) dipalladium (51 mg, 0.06 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (65 mg, 0.11 mmol) and cesium carbonate (1.1 g, 3.36 mmol) was added dioxane and the reaction flushed with nitrogen. The mixture was then heated at 65° C. overnight. After cooling, solvent was removed in vacuo and the crude material purified by silica chromatography (MeOH/EtOAc) to yield a yellow solid. ES/MS 553.3 (M+H + ). 
     N-(6-amino-8-chloro-3-cyanoquinolin-4-yl)benzamide 
     N-(8-chloro-3-cyano-6-nitroquinolin-4-yl)benzamide (216 mg, 0.61 mmol), calcium chloride (102 mg, 0.92 mmol), iron powder (102 mg, 1.8 mmol) were heated in ethanol (10 mL) and water (1 mL) at 60° C. for 4 hours. The reaction was cooled to room temperature and solids were removed via filtration. The solids were washed with EtOAc and the combined organic layers were washed with water, brine, and dried (Na 2 SO 4 ). Filtration and evaporation of all volatiles yielded the crude product which was carried forward as is. ES/MS 323.05 (M+H + ). 
     (S)—N-(6-(((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl)amino)-8-chloro-3-cyanoquinolin-4-yl)benzamide 
     Starting with N-(6-amino-8-chloro-3-cyanoquinolin-4-yl)benzamide title compound was prepared following final steps of example 2. ES/MS 637.2 (M+H + ). 
     Example 17 Procedure 17 
     
       
         
         
             
             
         
       
     
     (S)-6-(((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(3-(hydroxymethyl)phenyl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile 
     (S)-6-(((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile (247 mg, 0.31 mmol) was dissolved in THF (10 mL) at room temperature. Tetrabutylammonium fluoride (1.0M in THF, 0.38 mL, 0.38 mmol) was added and the resulting solution stirred for 30 minutes. Saturated aqueous NH 4 Cl solution (3 mL) was added to the reaction mixture and the resulting solution extracted with EtOAc (3×15 mL). The organic phase was washed with brine (5 mL), dried over MgSO 4  and concentrated. The residue was purified by and RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
       1 H NMR (400 MHz, Methanol-d 4 ) δ 8.44 (s, 1H), 7.78 (s, 1H), 7.65 (d, J=2.4 Hz, 1H), 7.47 (d, J=4.8 Hz, 2H), 7.38-7.23 (m, 5H), 7.18 (d, J=2.4 Hz, 1H), 6.02 (s, 1H), 4.89-4.71 (m, 1H), 4.58 (s, 2H), 3.79 (d, J=12.8 Hz, 2H), 3.21 (t, J=13.0 Hz, 2H), 2.42 (d, J=25.2 Hz, 4H), 1.46 (s, 9H). ES/MS 673.1 (M+H + ). 
     Example 18 Procedure 18 
     
       
         
         
             
             
         
       
     
     (S)-6-(((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(3-((dimethylamino)methyl)phenyl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile 
     (S)-6-(((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(3-(hydroxymethyl)phenyl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile (30.0 mg, 0.045 mmol) was dissolved in DCM (2 mL) at room temperature. Thionyl chloride (0.13 mL, 1.78 mmol) was added and the resulting solution stirred for 10 minutes after it was concentrated to dryness. To the crude residue was added DCM (2 mL) followed by dimethylamine (40% aqueous solution, 1 mL). After 4 hours the solvents were removed and the crude residue was purified by RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
       1 H NMR (400 MHz, Methanol-d 4 ) δ 8.45 (s, 1H), 8.00 (s, 1H), 7.67 (d, J=2.4 Hz, 1H), 7.65 (s, 1H), 7.56 (d, J=7.8 Hz, 1H), 7.53-7.40 (m, 3H), 7.36-7.23 (m, 2H), 7.21 (d, J=2.3 Hz, 1H), 6.09 (s, 1H), 4.80 (d, J=5.1 Hz, 1H), 4.35-4.21 (m, 2H), 3.79 (d, J=12.7 Hz, 2H), 3.28-3.16 (m, 2H), 2.80 (s, 6H), 2.45 (m, 4H), 1.46 (s, 9H). 
     ES/MS 700.2 (M+H + ). 
     Example 19 Procedure 19 
     
       
         
         
             
             
         
       
     
     (S)-3-((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)methyl)benzoic acid 
     methyl (S)-3-((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)methyl)benzoate (50.0 mg, 0.071 mmol) was dissolved in MeOH (2 mL) and water (0.5 mL) after which solid NaOH (14.3 mg, 0.36 mmol) was added and the reaction mixture allowed to stir at room temperature overnight. The mixture was diluted with EtOAc (30 mL), dried over MgSO 4 , and concentrated. The crude residue was purified by and RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
     ES/MS 687.0 (M+H + ). 
     Example 20 Procedure 20 
     
       
         
         
             
             
         
       
     
     (S)-3-((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)methyl)-N,N-dimethylbenzamide 
     (S)-3-((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)methyl)benzoic acid (30.0 mg, 0.044 mmol) was dissolved in DMF (2 mL) at room temperature. Dimethylamine (2.0M in MeOH, 0.22 mL, 0.44 mmol), diisopropylethylamine (0.023 mL, 0.131 mmol) and HATU (25 mg, 0.065 mmol) were then added and the reaction mixture stirred for 12 hours. The reaction mixture was poured into water (3 mL) and extracted with EtOAc (3×8 mL). The organic phase was washed with brine (5 mL), dried over MgSO 4  and concentrated. The crude residue was then purified by RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
       1 H NMR (400 MHz, Methanol-d 4 ) δ 8.43 (s, 1H), 7.84 (s, 1H), 7.65 (d, J=2.3 Hz, 1H), 7.56 (d, J=7.8 Hz, 1H), 7.51 (s, 1H), 7.46 (t, J=7.7 Hz, 2H), 7.37 (d, J=7.6 Hz, 1H), 7.32 (t, J=8.8 Hz, 1H), 7.25 (d, J=2.9 Hz, 1H), 7.15 (d, J=2.4 Hz, 1H), 6.07 (s, 1H), 4.82-4.72 (m, 1H), 3.81 (d, J=13.0 Hz, 2H), 3.21 (d, J=12.3 Hz, 2H), 3.06 (s, 3H), 2.88 (s, 3H), 2.54-2.32 (m, 4H), 1.46 (s, 9H). ES/MS 714.0 (M+H + ). 
     Example 21 Procedure 21 
     
       
         
         
             
             
         
       
     
     (S)-6-(((3-acetylphenyl)(1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile 
     6-(((1S)-(1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(3-(1-hydroxyethyl)phenyl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile (41 mg, 0.060 mmol) was dissolved in DCM (2 mL) after which Dess-Martin periodinane (30.4 mg, 0.072 mmol) was added at room temperature. After 30 minutes the reaction contents were quenched by the addition of saturated aqueous Na 2 SO 3  (3 mL) and stirred vigorously for 5 minutes. The reaction mixture was then poured into saturated aqueous NaHCO 3  (5 mL) and extracted with EtOAc (2×15 mL). The combined organic phase was washed with brine (5 mL), dried over MgSO 4  and concentrated. The crude residue was purified by and RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
     Example 22 Procedure 22 
     
       
         
         
             
             
         
       
     
     6-(((1S)-(1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(3-(1-hydroxyethyl)phenyl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile 
     (S)-6-(((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(3-formylphenyl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile (78 mg, 0.12 mmol) was dissolved in THF (5 mL) and brought to 0° C. Methylmagnesium chloride (3.0M in THF, 0.077 mL, 0.23 mmol) was added dropwise. After 5 minutes the reaction contents were quenched by the addition of water and the aqueous phase extracted with EtOAc (3×8 mL). The organic phase was washed with brine (5 mL), dried over MgSO 4  and concentrated. The crude residue was then purified by and RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
       1 H NMR (400 MHz, Methanol-d 4 ) δ 8.47 (s, 1H), 7.81 (d, J=3.4 Hz, 1H), 7.68 (d, J=2.3 Hz, 1H), 7.53 (dd, J=11.1, 4.7 Hz, 2H), 7.41-7.24 (m, 6H), 6.06 (s, 1H), 4.80 (m, 2H), 3.79 (d, J=12.6 Hz, 2H), 3.23 (d, J=12.6 Hz, 2H), 2.43 (m, 4H), 1.46 (s, 9H), 1.37 (d, J=6.4 Hz, 3H). ES/MS 687.2 (M+H + ). 
     Example 23 Procedure 23 
     
       
         
         
             
             
         
       
     
     (S)-6-(((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(3-(oxazol-2-yl)phenyl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile 
     (S)-6-(((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(3-iodophenyl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile (93 mg, 0.26 mmol), tetrakis(triphenylphosphine)palladium(O) (15 mg, 0.013 mmol), 2-tributyltinoxazole (21 mg, 0.065 mmol) and lithium chloride (5.5 mg, 0.13 mmol) were combined in DMF (1.5 mL) and purged with argon. The reaction mixture was heated to 90° C. overnight. After passing the reaction mixture through a silica-thiol plug the solvents were removed and the crude residue purified by RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
     ES/MS 710.1 (M+H + ). 
     Example 24 Procedure 24 
     
       
         
         
             
             
         
       
     
     (S)-6-(((3-aminophenyl)(1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile 
     (S)—N-(3-((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)methyl)phenyl)acetamide (20.0 mg, 0.029 mmol) was dissolved in EtOH (5 mL) after which NaOH (3.0M aq, 2.5 mL, 7.5 mmol) was added and the resulting solution heated to 70° C. for 24 hours. The reaction contents were poured into water (5 mL) and extracted with EtOAc (3×15 mL). The combined organic phases were washed with brine (5 mL), dried over MgSO 4  and concentrated. The crude residue was purified by RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
     ES/MS 658.0 (M+H + ). 
     Example 25 Procedure 25 
     
       
         
         
             
             
         
       
     
     (S)—N-(3-((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)methyl)phenyl)methanesulfonamide 
     (S)—N-(3-((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)methyl)phenyl)-N-(methylsulfonyl)acetamide (47 mg, 0.061 mmol) was dissolved in MeOH (2 mL) at room temperature. NaOH (1.0M aq, 0.30 mL, 0.30 mmol) was added and the reaction stirred for 30 minutes. HCl ((1.0M aq, 0.30 mL, 0.30 mmol) was added after which the reaction mixture was poured into water (3 mL) and extracted with EtOAc (3×8 mL). The combined organic phases were washed with brine (5 mL), dried over MgSO 4  and concentrated. The crude residue was purified by RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
     ES/MS 736.0 (M+H + ). 
     Example 26 Procedure 26 GS-713242 
     (S) 8-chloro-6-(((2-chlorophenyl)(1-(1,1-difluoro-2-hydroxyethyl)-1H-1,2,3-triazol-4-yl)methyl-d)amino)-4-(neopentylamino)quinoline-3-carbonitrile 
     
       
         
         
             
             
         
       
     
     Ethyl 2-azido-2,2-difluoroacetate (11.2 mg, 0.068 mmol) was added to a solution of 8-chloro-6-((1-(2-chlorophenyl)prop-2-yn-1-yl-1-d)amino)-4-(neopentylamino)quinoline-3-carbonitrile (20 mg, 0.046 mmol) and Copper(I) thiophene-2-carboxylate (0.9 mg, 0.005 mmol) in THF (2 mL). After 45 minutes, the reaction was diluted with EtOAc (10 mL). The organic phase was washed with saturated sodium bicarbonate (5 mL) and brine (5 mL). The organic phase was dried over sodium sulfate and the solvent was removed under reduced pressure. The residue was taken up in MeOH (3 mL) and sodium borohydride (35 mg, 0.91 mmol). After 15 minutes the mixture was diluted with EtOAc (20 ml) and washed with saturated sodium bicarbonate (5 mL) and brine (5 mL). The organic phase was dried over sodium sulfate and the solvent was removed under reduced pressure. The residue was subjected to flash chromatography. The fractions containing product were combined and the solvent was removed under reduced pressure. The product was subjected to further purification via RP-HPLC. The fractions containing product were combined and subjected to lyophilization, providing (S) 8-chloro-6-(((2-chlorophenyl)(1-(1,1-difluoro-2-hydroxyethyl)-1H-1,2,3-triazol-4-yl)methyl-d)amino)-4-(neopentylamino)quinoline-3-carbonitrile. 
     ES/MS 561.1 (M+H + ). 
     Example 27 Procedure 27 
     8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-(((1-(1-ethylpiperidin-4-yl)-1H-imidazol-4-yl)(phenyl)methyl)amino)quinoline-3-carbonitrile 
     
       
         
         
             
             
         
       
     
     tert-butyl 4-(4-formyl-1H-imidazol-1-yl)piperidine-1-carboxylate 
     Sodium hydride (60% suspension in mineral oil) (458 mg, 11.5 mmol) was added in portions to a solution of 1H-imidazole-4-carbaldehyde (1 g, 10.4 mmol) in dimethylformamide (16 mL) at 0° C. After 30 min at 0° C. the mixture was allowed to warm to RT and tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate (2.9 g, 10.5 mmol) was added. The mixture was heated at 100° C. for 16 h. The reaction was cooled and diluted with ethyl acetate (75 mL). The organic phase was washed with water (2×25 mL) and brine (25 mL) and dried over sodium sulfate. The solvent was removed under reduced pressure and the residue was subjected to flash chromatography (0-100% ethyl acetate/hexane) to remove side products and undesired regioisomer. The solvent was removed under reduced pressure providing tert-butyl 4-(4-formyl-1H-imidazol-1-yl)piperidine-1-carboxylate. 
     tert-butyl 4-(4-(hydroxy(phenyl)methyl)-1H-imidazol-1-yl)piperidine-1-carboxylate 
     Phenyl magnesiumbromide (1M in tetrahydrofuran) (1.3 mL, 1.28 mmol) was added to a solution of tert-butyl 4-(4-formyl-1H-imidazol-1-yl)piperidine-1-carboxylate (325 mg, 1.16 mmol) in tetrahydrofuran (10 mL). After 2 h the reaction was quenched with saturated ammonium chloride (10 mL) and diluted with ethyl acetate (25 mL). The organic phase was washed with brine (10 mL) and dried over sodium sulfate. The solvent was removed under reduced pressure, providing tert-butyl 4-(4-(hydroxy(phenyl)methyl)-1H-imidazol-1-yl)piperidine-1-carboxylate. 
     tert-butyl 4-(4-benzoyl-1H-imidazol-1-yl)piperidine-1-carboxylate 
     A solution of tert-butyl 4-(4-(hydroxy(phenyl)methyl)-1H-imidazol-1-yl)piperidine-1-carboxylate (408 mg, 1.1 mmol) and Dess-Martin periodinane (515 mg, 1.4 mmol) in dichloromethane (10 mL was stirred at room temperature for 2 h. The solvent was removed under reduced pressure and the residue was taken up in ethyl acetate (25 mL). The organic phase was washed with saturated sodium bicarbonate (10 mL). A solid formed which was removed by filtration. The organic phase was washed again with saturated sodium bicarbonate (10 mL) and brine (10 mL). The organic phase was dried over sodium sulfate and the solvent was removed under reduced pressure. The residue was subjected to flash chromatography (0-100% ethyl acetate/hexanes). The fractions containing product were combined and the solvent was removed under reduced pressure providing tert-butyl 4-(4-benzoyl-1H-imidazol-1-yl)piperidine-1-carboxylate. 
     tert-butyl 4-(4-(((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)(phenyl)methyl)-1H-imidazol-1-yl)piperidine-1-carboxylate 
     A solution of 6-amino-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile (98 mg, 0.28 mmol) and tert-butyl 4-(4-benzoyl-1H-imidazol-1-yl)piperidine-1-carboxylate (100 mg, 0.28 mmol) in dichloromethane (2 mL) was cooled to 0° C. under Argon. Triethylamine (125 μL, 0.90 mmol) was added followed by titanium (IV) tetrachloride (0.21 mL, 0.21 mmol-1M in DCM). After 20 h the reaction was diluted with methanol (1 mL) and sodium borohydride (43 mg, 1.1 mmol) was added. After 40 h the reaction was quenched with saturated sodium bicarbonate (5 mL) and partitioned with ethyl acetate (15 mL). The organic phase was washed with saturated sodium bicarbonate (10 mL), brine (10 mL), and dried over sodium sulfate. The solvent was removed under reduced pressure and the residue was subjected to flash chromatography (0-100% ethyl acetate/hexanes). The fractions containing product were combined and the solvent was removed under reduced pressure, providing tert-butyl 4-(4-(((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)(phenyl)methyl)-1H-imidazol-1-yl)piperidine-1-carboxylate. 
     8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-((phenyl(1-(piperidin-4-yl)-1H-imidazol-4-yl)methyl)amino)quinoline-3-carbonitrile 
     Zinc bromide (105 mg, 0.47 mmol) was added to a solution of tert-butyl 4-(4-(((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)(phenyl)methyl)-1H-imidazol-1-yl)piperidine-1-carboxylate (64 mg, 0.094 mmol) in nitromethane (1 mL). After 3 h the solvent was removed under reduced pressure. The residue was partitioned between ethyl acetate (20 mL) and saturated sodium bicarbonate (10 mL). Solid formed which was removed by filtration. The organic phase was washed with saturated sodium bicarbonate (10 mL) and brine (10 mL). The organic phase was dried over sodium sulfate and the solvent was removed under reduced pressure, providing 8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-((phenyl(1-(piperidin-4-yl)-1H-imidazol-4-yl)methyl)amino)quinoline-3-carbonitrile. 
     ES/MS 585.9 (M+H + ). 
     8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-(((1-(1-ethylpiperidin-4-yl)-1H-imidazol-4-yl)(phenyl)methyl)amino)quinoline-3-carbonitrile 
     8-Chloro-4-((3-chloro-4-fluorophenyl)amino)-6-((phenyl(1-(piperidin-4-yl)-1H-imidazol-4-yl)methyl)amino)quinoline-3-carbonitrile (41 mg, 0.070 mmol), acetaldehyde (9.7 μL, 0.17 mmol) and sodium triacetoxyborohydride (59 mg, 0.28 mmol) were dissolved in tetrahydrofuran (1 mL) and 1,1-dichloroethane (1 mL) and stirred at room temperature for 30 minutes. The mixture was diluted with ethyl acetate (10 mL) and washed twice with saturated sodium bicarbonate (5 mL) and brine (5 mL). The organic phase was dried over sodium sulfate and the solvent was removed under reduced pressure. The residue was subjected to flash chromatography. The fractions containing product were combined and the solvent was removed under reduced pressure. The residue was taken up in methanol and water with two drops of trifluoroacetic acid and subjected to preparative HPLC. The cleaner fractions were combined and subjected to lyophilization, providing 8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-(((1-(1-ethylpiperidin-4-yl)-1H-imidazol-4-yl)(phenyl)methyl)amino)quinoline-3-carbonitrile. 
       1 H NMR D 2 O exchange (400 MHz, DMSO-d6) δ 9.05 (s, 1H), 8.97 (s, 1H), 8.42 (s, 1H), 7.64 (d, J=2.4 Hz, 1H), 7.55 (s, OH), 7.47-7.42 (m, 4H), 7.42-7.36 (m, 4H), 7.36-7.30 (m, 2H), 7.19 (qd, J=4.1, 2.8 Hz, 3H), 5.96 (s, 1H), 4.51-4.38 (m, 1H), 3.58 (d, J=13.0 Hz, 4H), 3.25 (d, J=12.2 Hz, 1H), 3.12 (q, J=7.3 Hz, 2H), 3.06-2.93 (m, 2H), 2.35-2.25 (m, 3H), 2.05-1.91 (m, 2H), 1.20 (t, J=7.3 Hz, 3H). 
     ES/MS 613.9 (M+H + ). 
     Example 28 Procedure 28 
     
       
         
         
             
             
         
       
     
     (S)-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-4-(neopentylamino)-8-(pyridin-2-yl)quinoline-3-carbonitrile 
     To (S)-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-8-iodo-4-(neopentylamino)quinoline-3-carbonitrile (55 mg, 0.09 mmol), 6-methyl-2-(pyridin-2-yl)-1,3,6,2-dioxazaborocane-4,8-dione (32 mg, 0.13 mmol), [1,1′-bis(diphenylphosphino)ferrocene] dichloropalladium(II), complex with dichloromethane (6 mg, 0.009 mmol), diethanolamine (10 mg, 0.09 mmol), cupric acetate (8 mg, 0.046 mmol) and potassium phosphate tribasic (98 mg, 0.46 mmol) was added DMF (1 mL) and the reaction mixture degassed with nitrogen. The reaction mixture was then heated at 85° C. overnight. After filtering the solids through a pad of celite, the crude filtrate was concentrated and purified by HPLC (eluent: water/MeCN*0.1% TFA) to give the title compound. ES/MS 548.2 (M+H + ). 
     Example 29 Procedure 29 
     
       
         
         
             
             
         
       
     
     6-(((S)-(1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-8-(1-hydroxyethyl)-4-(neopentylamino)quinoline-3-carbonitrile 
     Made by reduction of (S)-8-acetyl-6-(((2-chlorophenyl)(1-cyclopropyl-1H-1,2,3-triazol-4-yl)methyl-d)amino)-4-(neopentylamino)quinoline-3-carbonitrile with sodium triacetoxyborohydride. ES/MS 515.3 (M+H + ). 
     Example 30 Procedure 30 
     
       
         
         
             
             
         
       
     
     6-(((S)-(1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-8-ethynyl-4-(((R)-1-phenylpropyl)amino)quinoline-3-carbonitrile 
     To 8-bromo-6-(((S)-(1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-4-(((R)-1-phenylpropyl)amino)quinoline-3-carbonitrile (80 mg, 0.13 mmol) in DMF (0.5 mL) was added ethynyltrimethylsilane (40 mg, 0.4 mmol), bis(triphenylphosphine) palladium (II) dichloride (9 mg, 0.013 mmol), copper (I) iodide (3 mg, 0.013 mmol) and triethylamine (0.3 mL). The reaction mixture was flushed with nitrogen and heated at 95° C. for 3 hours. After removing most of the solvent in vacuo, the crude residue was purified by HPLC (eluent: water/MeCN*0.1% TFA) to give the title compound. 
     ES/MS 543.3 (M+H + ). 
     Example 31 Procedure 31 
     
       
         
         
             
             
         
       
     
     (S)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-(((4-fluorophenyl)(1-(piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)amino)quinoline-3-carbonitrile hydrochloride (30 mg, 0.05 mmol) was dissolved in 0.50 mL of 3:1 2-methyltetrahyrdofuran: acetic acid and treated with oxetanone (10 mg, 0.14 mmol) and PS—BH 3 CN (polystyrene supported cyanoborohydride, 22 mg, 2.17 mmol/g). The mixture was stirred overnight. The resin was filtered and the resulting filtrate was concentrated. Purification using RP-HPLC (eluent: water/MeCN*0.1% TFA) provided the product as trifluoroacetate salt. 
     ES/MS 661.1 (M+H + ) 
     Example 32 Procedure 32 
     8-chloro-6-(((S)-(1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl)amino)-4-(((R)-3-fluoro-1-phenylpropyl)amino)quinoline-3-carbonitrile 
     
       
         
         
             
             
         
       
     
     Step 1, (R)-8-chloro-4-((3-hydroxy-1-phenylpropyl)amino)-6-nitroquinoline-3-carbonitrile 
     4,8-dichloro-6-nitroquinoline-3-carbonitrile (400 mg, 1.49 mmol), (R)-3-amino-3-phenylpropan-1-ol (270.76 mg, 1.79 mmol) in iso-propanol (1.5 mL) were heated under microwave conditions at 150° C. for 45 minutes. The reaction was cooled to room temperature. Water and Et 2 O were added. The aqueous layer was extracted with Et 2 O and the combined organic layers were dried over sodium sulfate. Filtration and evaporation of solvents yielded the crude product which was used in the next step without further purification. 
     ES/MS 383.1 (M+H + ). 
     Step 2, (R)-8-chloro-4-((3-fluoro-1-phenylpropyl)amino)-6-nitroquinoline-3-carbonitrile 
     (R)-8-chloro-4-((3-hydroxy-1-phenylpropyl)amino)-6-nitroquinoline-3-carbonitrile (100 mg, 0.26 mmol) was treated with deoxofluor (0.6 mL) at room temperature for 16 hours. The reaction mixture was cooled in an ice bath and carefully quenched with saturated sodium bicarbonate solution, then extracted with ethyl acetate. The organic phase was dried over sodium sulfate, filtered and concentrated to give the crude product which was used without further purification. 
     ES/MS 385.1 (M+H + ). 
     Step 3, (R)-6-amino-8-chloro-4-((3-fluoro-1-phenylpropyl)amino)quinoline-3-carbonitrile 
     (R)-8-chloro-4-((3-fluoro-1-phenylpropyl)amino)-6-nitroquinoline-3-carbonitrile (115 mg, 0.3 mmol), Calcium chloride dihydrate (65.91 mg, 0.45 mmol), and iron powder (83.5 mg, 1.49 mmol) were heated in ethanol (3 mL)/water (0.3 mL) at 60° C. for 12 hours. The reaction was cooled to room temperature and solids were removed via filtration. The solids were washed with EtOAc and the combined organic layers were washed with aqueous sodium bicarbonate solution, brine, and were dried over sodium sulfate. Filtration and evaporation of all volatiles yielded the product. 
     ES/MS 355.0 (M+H + ). 
     Step 4. 8-chloro-6-(((S)-(1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl)amino)-4-(((R)-3-fluoro-1-phenylpropyl)amino)quinoline-3-carbonitrile 
     (R)-6-amino-8-chloro-4-((3-fluoro-1-phenylpropyl)amino)quinoline-3-carbonitrile (45 mg, 0.13 mmol), CuI (1.2 mg, 0.05 mmol) and 2,6-bis((4S,5R)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine [oxazoline ligand] (3.9 mg, 0.06 mmol) were sonicated in MeOH (2.0 mL) for about 1 minute. Alkynyl acetate (29 mg, 0.15 mmol) and di-isopropyl ethyl amine (19.7 mg, 0.15 mmol) were added and the reaction was stirred overnight. Cyclopropylazide (43 mg, 0.52 mmol) was added and the reaction was stirred for additional 16 hrs at room temperature. The material was partitioned between ethyl acetate and water and the organic phase was dried over sodium sulfate and filtered. Solvents were removed in vacuo and the crude material was purified by RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoroacetate salt. 
     1H NMR (400 MHz, Methanol-d4) δ 8.41 (s, 1H), 7.83 (m, 1H), 7.65 (m, 1H), 7.54-7.18 (m, 8H), 7.16-7.03 (m, 2H), 6.17-6.05 (m, 2H), 4.93-4.76 (m, 2H), 4.67-4.58 (m, 1H), 4.51 (m, 1H), 3.93-3.82 (m, 1H), 1.26-1.09 (m, 4H). 
     ES/MS 570.1 (M+H + ). 
     Example 33 Procedure 33 
     N-(8-chloro-3-cyano-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)quinolin-4-yl)pivalamide 
     
       
         
         
             
             
         
       
     
     Step 1. 4-amino-8-chloro-6-nitroquinoline-3-carbonitrile 
     (S)-8-chloro-4-((2-hydroxy-1-phenylethyl)amino)-6-nitroquinoline-3-carbonitrile (256 mg, 0.69 mmol) was treated with deoxofluor (0.6 mL) at room temperature for 16 hours. The reaction mixture was cooled in an ice bath and carefully quenched with saturated sodium bicarbonate solution, then extracted with ethyl acetate. The organic phase was dried over sodium sulfate, filtered and concentrated to give the crude product which was used without further purification. 
     ES/MS 249.1 (M+H + ). 
     Step 2. N-(8-chloro-3-cyano-6-nitroquinolin-4-yl)pivalamide 
     4-amino-8-chloro-6-nitroquinoline-3-carbonitrile (163 mg, 0.66 mmol), pivaloyl chloride (0.32 ml, 2.62 mmol), triethylamine, 99% (398.04 mg, 3.93 mmol), and DCM (6 ml) were combined and stirred for 2 days. The reaction mixture was concentrated, then taken up in ethyl acetate and washed with 1N HCl, saturated sodium bicarbonate and brine, then dried over sodium sulfate. Filtration and evaporation of all volatiles yielded the product. 
     ES/MS 333.0 (M+H + ). 
     Step 3. N-(6-amino-8-chloro-3-cyanoquinolin-4-yl)pivalamide 
     To a suspension of N-(8-chloro-3-cyano-6-nitroquinolin-4-yl)pivalamide (48 mg, 0.14 mmol) in EtOH (1.4 ml) was added stannous chloride, dihydrate (65.1 mg, 0.29 mmol). The resulting suspension was heated at 60° C. for 16 hours. The mixture was cooled to room temperature and quenched carefully with saturated sodium bicarbonate. Extraction with ethyl acetate, drying over anhydrous sodium sulfate, filtration and concentration gave the product. 
     ES/MS 303.2 (M+H + ). 
     Step 4. N-(8-chloro-3-cyano-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)quinolin-4-yl)pivalamide 
     CuI (1.3 mg, 0.007 mmol) and 2,6-bis((4S,5R)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine [oxazoline ligand] (4.1 mg, 0.06 mmol) were sonicated in MeOH (2.0 mL) for about 1 minute. Alkynyl acetate (29 mg, 0.15 mmol), N-(6-amino-8-chloro-3-cyanoquinolin-4-yl)pivalamide (40 mg, 0.13 mmol) and di-isopropyl ethyl amine (19.7 mg, 0.15 mmol) were added and the reaction was stirred for 1 hour. Cyclopropylazide (20 mg, 0.50 mmol) was added and the reaction was stirred at room temperature until complete. The crude reaction mixture was passed through a syringe filtered directly, and was purified by RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoroacetate salt. 
     1H NMR (400 MHz, Methanol-d4) δ 9.11 (s, 1H), 7.84 (s, 1H), 7.70 (m, 2H), 7.56 (m, 2H), 7.10 (m, 2H), 4.96-4.86 (m, 1H), 3.93-3.82 (m, 1H), 1.46 (s, 9H), 1.25-1.09 (m, 4H). 
     ES/MS 519.3 (M+H + ). 
     Example 34 Procedure 34 
     8-chloro-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-4-(((R)-3-morpholino-1-phenylpropyl)amino)quinoline-3-carbonitrile 
     
       
         
         
             
             
         
       
     
     (R)-3-((8-chloro-3-cyano-6-nitroquinolin-4-yl)amino)-3-phenylpropyl methanesulfonate 
     To a solution of (R)-8-chloro-4-((3-hydroxy-1-phenylpropyl)amino)-6-nitroquinoline-3-carbonitrile (1000 mg, 2.61 mmol) and triethylamine, 99% (0.62 ml, 4.44 mmol) in DCM (12 ml) was added methanesulfonyl chloride (0.3 ml, 3.92 mmol). After 1 hour, an additional portion of both methanesulfonyl chloride and triethylamine were added. After 15 minutes, ice was added and the product was extracted into ethyl acetate and washed with brine. Drying over sodium sulfate, filtration and concentration gave the crude product which was used without further purification. 
     ES/MS 461.0 (M+H + ). 
     (R)-8-chloro-4-((3-morpholino-1-phenylpropyl)amino)-6-nitroquinoline-3-carbonitrile 
     (R)-3-((8-chloro-3-cyano-6-nitroquinolin-4-yl)amino)-3-phenylpropyl methanesulfonate (100 mg, 0.22 mmol) and morpholine (0.19 ml, 2.17 mmol) were heated together at 70° C. for 1 hour. Water was added and the product was extracted into ethyl acetate, washed water and brine, and dried over sodium sulfate. Filtration and evaporation of all volatiles yielded the crude product. 
     ES/MS 452.1 (M+H + ). 
     (R)-6-amino-8-chloro-4-((3-morpholino-1-phenylpropyl)amino)quinoline-3-carbonitrile 
     To a suspension of (R)-8-chloro-4-((3-morpholino-1-phenylpropyl)amino)-6-nitroquinoline-3-carbonitrile (106 mg, 0.23 mmol) in EtOH (2.3 ml) was added stannous chloride dihydrate (89.0 mg, 0.47 mmol). The resulting suspension was heated at 70° C. for 16 hours. The mixture was cooled to room temperature and quenched carefully with saturated sodium bicarbonate. Extraction with ethyl acetate, drying over anhydrous sodium sulfate, filtration and concentration gave the crude product which was carried on to the next step without purification. 
     ES/MS 422.0 (M+H + ). 
     8-chloro-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-4-(((R)-3-morpholino-1-phenylpropyl)amino)quinoline-3-carbonitrile 
     CuI (1.3 mg, 0.007 mmol) and 2,6-bis((4S,5R)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine [oxazoline ligand] (4.1 mg, 0.06 mmol) were sonicated in MeOH (2.0 mL) for about 1 minute. Alkynyl acetate (45 mg, 0.24 mmol), (R)-6-amino-8-chloro-4-((3-morpholino-1-phenylpropyl)amino)quinoline-3-carbonitrile (50 mg, 0.12 mmol), and di-isopropyl ethyl amine (18.3 mg, 0.14 mmol) were added and the reaction was stirred for 16 hours. Cyclopropylazide (20 mg, 0.50 mmol) was added and the reaction was stirred at room temperature until complete. The crude reaction mixture was passed through a syringe filtered directly, and was purified by RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoroacetate salt. 
     ES/MS 638.0 (M+H + ) 
     Example 35 Procedure 35 
     (S)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-(((4-fluorophenyl)(1-(1-(2-methoxyethyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)amino)quinoline-3-carbonitrile 
     
       
         
         
             
             
         
       
     
     A solution of (S)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-(((4-fluorophenyl)(1-(piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)amino)quinoline-3-carbonitrile hydrochloride (30 mg, 0.05 mmol) in 0.5 mL of acetonitrile was treated with cesium carbonate (45.7 mg, 0.14 mmol) and 2-Bromoethyl methyl ether (0.005 ml, 0.05 mmol) and stirred overnight, then heated at 50° C. for 3 hours. A drop of 2-bromoethyl methyl ether was added and the reaction was continued at 50° C. for 12 hours. Purification by RP-HPLC (eluent: water/MeCN*0.1% TFA) gave the product. 
     ES/MS 663.3 (M+H + ) 
     Example 36 Procedure 36 
     8-chloro-6-(((3-cyanophenyl)(1-cyclopropyl-1H-1,2,3-triazol-4-yl)methyl-d)amino)-5-fluoro-4-(((R)-1-phenylpropyl)amino)quinoline-3-carbonitrile 
     
       
         
         
             
             
         
       
     
     To a solution of 8-chloro-6-(((S)-(3-cyanophenyl)(1-cyclopropyl-1H-1,2,3-triazol-4-yl)methyl-d)amino)-4-(((R)-1-phenylpropyl)amino)quinoline-3-carbonitrile (23.9 mg, 0.043 mmol) in acetonitrile (0.8 ml) was added Selectfluor® II reagent (16.38 mg, 0.05 mmol). The reaction was monitored by LCMS. Once complete, it was passed through a syringe filter and purified by RP-HPLC (eluent: water/MeCN*0.1% TFA) to give the product as trifluoroacetate salt. 
     Example 37 Procedure 37 
     8-chloro-6-(((S)-(3-cyanophenyl)(1-cyclopropyl-1H-1,2,3-triazol-5-yl)methyl-d)amino)-4-(((R)-1-phenylpropyl)amino)quinoline-3-carbonitrile 
     
       
         
         
             
             
         
       
     
     Cyclopropyl azide (15.6 mg, 0.068 mmol) was added to a solution of the 8-chloro-6-(((R)-1-(3-cyanophenyl)prop-2-yn-1-yl-1-d)amino)-4-(((R)-1-phenylpropyl)amino)quinoline-3-carbonitrile (25 mg, 0.052 mmol) and chloro(pentamethylcyclopentadienyl)(cyclooctadiene)ruthenium(II) (4.5 mg, 0.010 mmol) in toluene (degassed with Argon for 20 minutes) (2 mL) under an atmosphere of Argon in an oven dried vial. After stirring for 1 h at room temperature the solvent was removed under reduced pressure. The residue was subjected to flash chromatography (0-100% (20% methanol in ethyl acetate)/hexanes). The fractions containing product were combined and the solvent was removed under reduced pressure. The residue was taken up in water and methanol with 2 drops of trifluoroacetic acid and subjected to preparative HPLC. The clean fractions were combined and subjected to lyophilization, providing 8-chloro-6-(((S)-(3-cyanophenyl)(1-cyclopropyl-1H-1,2,3-triazol-5-yl)methyl-d)amino)-4-(((R)-1-phenylpropyl)amino)quinoline-3-carbonitril [catalyst: J. Am. Chem. Soc., 2008 p. 8923] 
     Example 38 Procedure 38 
     (S)-6-(((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(3-(methoxymethyl)phenyl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile 
     
       
         
         
             
             
         
       
     
     (S)-6-(((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(3-(hydroxymethyl)phenyl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile (20.0 mg, 0.030 mmol) was dissolved in DMF (2 mL) and brought to 0° C. NaH (60% dispersion in mineral oil, 1.5 mg, 0.060 mmol) was then added and the resulting mixture stirred for 30 minutes. Iodomethane (0.007 mL, 0.12 mmol) was then added, the cold bath removed, and the reaction mixture allowed to warm to room temperature over 1 hour. The reaction contents were quenched by the addition of water (3 mL) which was extracted with EtOAc (3×8 mL). The organic phase was washed with brine (5 mL), dried over MgSO 4 , and concentrated. The residue was purified by and RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
     Example 39 Procedure 39 
     (S)-methyl 3-((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)(methyl)amino)methyl)benzoate 
     
       
         
         
             
             
         
       
     
     (S)-3-((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)methyl)benzoic acid (30.0 mg, 0.044 mmol), potassium carbonate (60.3 mg, 0.44 mmol) and iodomethane (0.011 mL, 0.18 mmol) were combined in acetone (2 mL) and stirred at room temperature for 4 hours. The reaction mixture was poured into water (3 mL) and extracted with EtOAc (3×8 mL). The organic phase was washed with brine (5 mL), dried over MgSO 4 , and concentrated. The residue was purified by and RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
     Example 40 Procedure 40 
     (S)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-(((3-((2-(dimethylamino)ethoxy)methyl)phenyl)(1-isopropyl-1H-1,2,3-triazol-4-yl)methyl)amino)quinoline-3-carbonitrile 
     
       
         
         
             
             
         
       
     
     (S)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-(((3-(hydroxymethyl)phenyl)(1-isopropyl-1H-1,2,3-triazol-4-yl)methyl)amino)quinoline-3-carbonitrile (15.0 mg, 0.026 mmol) was dissolved in DCM (2 mL) at room temperature. Thionyl chloride (0.13 mL, 1.78 mmol) was added and the resulting solution stirred for 10 minutes after it was concentrated to dryness. In a separated flask, a solution of dimethylethanolamine (0.13 mL, 1.3 mmol) in DMF (2 mL) was treated with NaH (60% dispersion in mineral oil, 28 mg, 1.2 mmol) at 0° C. for 30 minutes. The newly formed chloride was taken up in DMF (1 mL) and added to the alkoxide solution at 0° C. after which the cold bath was removed and the reaction mixture allowed to warm to room temperature over 1 hour. The reaction contents were quenched by the addition of water and extracted with EtOAc (3×8 mL). The organic phase was washed with brine (5 mL), dried over MgSO 4  and concentrated. The crude residue was purified by RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
     Example 41 Procedure 41 
     
       
         
         
             
             
         
       
     
     (S)-3-(((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)(1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-N,N-dimethylbenzamide 
     (S)-tert-butyl 4-(4-(((8-chloro-4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)amino)(3-(dimethylcarbamoyl)phenyl)methyl)-1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate (123 mg, 0.12 mmol) was dissolved in DCM (4 mL) and TFA (1 mL) and stirred at room temperature for 30 minutes. The reaction mixture was then concentrated to dryness and dissolved in MeOH (4.5 mL) and AcOH (1.5 mL). Acetaldehyde (0.068 mL, 1.2 mmol) and PS—CNBH 3  (polystyrene supported cyanoborohydride, 480 mg, 2.17 mmol/g) were then added and the resulting mixture stirred at room temperature for 2 hours. The resin was filtered and the resulting filtrate concentrated and purified by RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
     Example 42 Procedure 42 
     (S)-6-(((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(3-formylphenyl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile 
     
       
         
         
             
             
         
       
     
     (S)-6-(((1-(1-(tert-butyl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)(3-(hydroxymethyl)phenyl)methyl)amino)-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile (15.0 mg, 0.022 mmol) was dissolved in DCM (2 mL) and manganese(IV) oxide (58 mg, 0.67 mmol) was added and the resulting mixture stirred at room temperature. After 12 hours the reaction mixture was filtered through celite and the filtrate concentrated. The residue was then purified by and RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. 
     Example 43 Procedure 43 
     (S)-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-8-hydroxy-4-(neopentylamino)quinoline-3-carbonitrile 
     
       
         
         
             
             
         
       
     
     The starting material (30 mg, 0.06 mmol) was dissolved in DBN (2 mL) and heated at 150° C. for 20 hrs and 170° C. for additional 20 hrs. The mixture was cooled to room temperature and partitioned between EtOAc and water. The organic layer was washed with brine and dried over Na 2 SO 4 . Filtration and evaporation of the solvent yielded the crude product. Purification via RP-HPLC (eluent: water/MeCN*0.1% TFA) yielded the product as a trifluoro acetate salt. 
     1H NMR (400 MHz, DMSO-d6) δ 8.35 (s, 1H), 7.97 (s, 1H), 7.49 (dd, J=8.6, 5.6 Hz, 2H), 7.10 (t, J=8.8 Hz, 2H), 6.91 (s, 1H), 6.70 (s, 1H), 6.05 (d, J=7.6 Hz, 1H), 4.08 (s, 1H), 4.00-3.86 (m, 1H), 3.51 (s, 1H), 1.16-1.00 (m, 4H), 0.89 (s, 9H). 
     Example 44 Procedure 44 
     
       
         
         
             
             
         
       
     
     (S)-8-chloro-4-((5,6-difluoropyridin-3-yl)amino)-6-((f(1-(fluoromethyl)-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)quinoline-3-carbonitrile 
     Solid K 2 CO 3  (145 mg, 1.05 mmol) was added to a string solution of (S)-8-chloro-4-((5,6-difluoropyridin-3-yl)amino)-6-(((4-fluorophenyl)(1H-1,2,3-triazol-4-yl)methyl-d)amino)quinoline-3-carbonitrile (133 mg, 0.26 mmol) in DMF (10 mL). The resulting suspension was heated to 120° C. then F 2 CHCl was bubbled through (10 bubbles/sec) for 15 min. The reaction mixture was cooled to rt then diluted with EtOAc (20 mL). The organic layer was washed with saturated NaHCO 3  (20 mL), brine (20 mL), dried over Na 2 SO 4 , and concentrated to give the crude product. HPLC afforded the title compound and regioisomers. 1H NMR (400 MHz, DMSO-d6) δ 9.56 (s, 1H), 8.44 (s, 1H), 8.25 (s, 1H), 8.04-7.94 (m, 2H), 7.70-7.60 (m, 1H), 7.55-7.42 (m, 3H), 7.25-7.11 (m, 3H), 6.51-6.39 (m, 1H), 6.32 (s, 1H). ES/MS 540.1 (M+H + ). 
     Example 45 Procedure 45 
     
       
         
         
             
             
         
       
     
     (S)-8-chloro-4-((5,6-difluoropyridin-3-yl)amino)-6-(((2-fluorophenyl)(1-methyl-1H-1,2,3-triazol-4-yl)methyl)amino)quinoline-3-carbonitrile 
     1.0 M TBAF in THF (0.15 mL, 0.15 mmol) was added to a stirring solution of (S)-8-chloro-4-((5,6-difluoropyridin-3-yl)amino)-6-(((2-fluorophenyl)(1-((trimethylsilyl)methyl)-1H-1,2,3-triazol-4-yl)methyl)amino)quinoline-3-carbonitrile (60 mg, 0.1 mmol, obtained per example 10) in THF (2 mL). The reaction mixture was stirred for 1 h then concentrated to give crude methyl triazole. HPLC purification afforded the title compound. 1H NMR (400 MHz, DMSO-d 6 ) δ 9.70 (s, 1H), 8.49 (s, 1H), 8.05-7.89 (m, 3H), 7.73 (d, J=2.2 Hz, 1H), 7.46 (td, J=7.9, 1.9 Hz, 1H), 7.41-7.28 (m, 2H), 7.24-7.11 (m, 3H), 6.25 (s, 1H), 4.00 (s, 3H). ES/MS 521.1 (M+H + ). 
     Example 46 Procedure 46 
     
       
         
         
             
             
         
       
     
     Oxone (1.5 g, 5.1 mmol) and acetone (3.7 mL, 51 mmol) were added to a stirring solution of 1-butene azide (0.1 g, 1 mmol) in DCM/NaHCO 3  (3 mL/5 mL) at 0° C. The resulting mixture was allowed to warm to rt and stirred for 1.5 hrs. The solution was extracted with DCM and the combined organic layers were dried and concentrated to give crude epoxide. The crude was redissolved in t-BuNH 2  (2.1 mL, 20 mmol). Lithium perchlorate (21 mg, 0.2 mmol) was added to the solution and stirred over night at rt. The resulting solution was used as is for the next step. 
     
       
         
         
             
             
         
       
     
     6-(((1S)-(1-(4-(tert-butylamino)-3-hydroxybutyl)-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-8-chloro-4-(((R)-1-phenylpropyl)amino)quinoline-3-carbonitrile 
     Synthesized according to example 2 with the azide synthesized in the previous step; 1H NMR (400 MHz, DMSO-d6) δ 8.30-8.18 (m, 2H), 8.00-7.94 (m, 1H), 7.63-7.53 (m, 3H), 7.44-7.12 (m, 10H), 5.52-5.31 (m, 1H), 4.84 (brs), 4.57-4.40 (m, 2H), 3.81-3.66 (m, 1H), 2.96 (t, J=11.0 Hz, 1H), 2.74 (d, J=11.4 Hz, 1H), 2.19-2.00 (m, 2H), 1.98-1.85 (m, 2H), 1.24 (s, 9H), 0.99-0.86 (m, 3H). ES/MS 656.3 (M+H + ). 
     Example 47 Procedure 47 
     
       
         
         
             
             
         
       
     
     The CuI (6.6 mg, 0.035 mmol) and ligand (22 mg, 0.042 mmol) were suspended in MeOH (5 mL) and sonicated under argon for 5 min. The acetate (72 mg, 0.42 mmol) was added followed by the amine (100 mg, 0.35 mmol) and DIPEA (54 mg, 0.42 mmol) in that order at room temperature. After 1 h the N-alkylation reactions was complete. Evaporation and purification on silica get (eluent: EtOAc in hexanes) yielded 96 mg of N-alkylated product. 48 mg of the material was taken into THF (2 mL). Azide stock (1 mL/1 eq.), Cu and CuSO4 were added. Stirring at room temperature for 30 min. Diluted with EtOAc, washed with water, brine and dried over magnesium sulfate. Filtration, evaporation, and purification via RP-HPLC (eluent: water/MeCN*0.1 TFA) yielded the product as TFA salt. 
       1 H NMR (400 MHz, Methanol-d4) δ 8.45 (s, 1H), 7.84 (s, 1H), 7.65 (d, J=2.3 Hz, 1H), 7.47 (d, J=7.2 Hz, 2H), 7.41-7.32 (m, 2H), 7.35-7.26 (m, 1H), 7.07 (d, J=2.3 Hz, 1H), 6.08 (s, 1H), 5.93 (t, J=54.7 Hz, 1H), 4.15 (d, J=13.9 Hz, 1H), 3.74 (d, J=14.0 Hz, 1H), 1.51 (s, 4H), 0.97 (s, 9H). 
     Example 48 Procedure 48 
     
       
         
         
             
             
         
       
     
     The starting material (43 mg, 0.08 mmol), Zn (0.7 mg, 0.01 mmol), PddppfCl 2  (1.2 mg, 0.002 mmol) and Zn(CN) 2  (11.4 mg, 0.097 mmol) were combined in dimethylacetamide (1 mL) and degassed for 2 min. The mixture was heated in a microwave reactor at 200° C. for 20 min. The mixture was filtered and purified via RP-HPLC. The product fractions were combined and subjected to lyophilization, providing the desired compound as TFA salt. (Note: in some cases partial conversion was observed. Addition of more catalyst and resubmission to the reaction conditions gave further conversion.) 
       1 H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 7.86 (s, 1H), 7.80 (d, J=2.5 Hz, 1H), 7.52-7.45 (m, 2H), 7.36 (dd, J=8.5, 6.6 Hz, 2H), 7.33-7.27 (m, 1H), 7.26 (d, J=2.5 Hz, 1H), 6.08 (s, 1H), 5.93 (t, J=54.7 Hz, 1H), 4.03 (d, J=13.8 Hz, 1H), 3.63 (d, J=13.9 Hz, 1H), 1.51 (s, 4H), 0.94 (s, 9H). 
     Example 49 Procedure 49 
     
       
         
         
             
             
         
       
     
     Bromide starting material (200 mg, 1.0 mmol), pyrazole (271 mg, 3.98 mmol), cuprous oxide (14.2 mg, 0.10 mmol), and sodium tert-butoxide (195 mg, 1.99 mmol) were combined in N-methyl pyrrolidinone (4 mL) and heated in a microwave reactor at 200° C. for 2 h. The reaction contents were diluted with EtOAc, washed with water, brine and dried over magnesium sulfate. After filtration and concentration the crude product was taken up in dichloromethane (10 mL) and Manganese (IV) oxide (2.16 g, 25 mmol) was added and the reaction stirred for 1 h at room temperature. The reaction contents were filtered through a pad of celite, concentrated, and was purified via silica gel chromatography (eluent: EtOAc/hexanes) to yield the product. 
     Example 50 Procedure 50 
     
       
         
         
             
             
         
       
     
     Aniline (1.5 g, 9.1 mmol) was dissolved in pyridine (45 mL) and diformylhydrazine (2.4 g, 27.2 mmol) was added as a single portion. Chlorotrimethylsilane (17.3 mL, 136.2 mmol) was added dropwise followed by triethylamine (8.9 mL, 63.6 mmol) dropwise. The reaction as heated overnight to 100° C. after which is was cooled to room temperature, diluted with EtOAc, washed with water, brine and dried over magnesium sulfate. Filtration and concentration was followed by silica gel chromatography (eluent: EtOAc/hexanes) to yield the product. 
     Ester (900 mg, 4.1 mmol) was dissolved in THF (15 mL) and brought to 0° C. after which lithium aluminum hydride (1.0M in Et 2 O, 4.1 mL, 4.1 mmol) was added dropwise. After 30 minutes the reaction contents were carefully quenched by the addition of water and extracted with EtOAc. The organic extract was washed with brine, dried over magnesium sulfate, filtered and concentrated. The newly formed alcohol was then taken up in DCM (20 mL) and manganese (IV) oxide (4.6 g, 53 mmol) was added and the reaction stirred for 1 h at room temperature. The reaction contents were filtered through a pad of celite and concentrated to yield the aldehyde product. 
     Example 51 Procedure 51 
     
       
         
         
             
             
         
       
     
     Dissolved aniline SM (1.0 g, 6.1 mmol) in 6N HCl solution (20 mL), brought to 0 deg in ice/water bath. Treated with aqueous solution of NaNO2 (418 mg, 6.1 mmol) in 1 mL water dropwise. Let stir 10 minutes at 0 deg then added NaN3 (472 mg, 7.3 mmol) as an aqueous solution in 2 mL water. The cold bath was removed and the reaction mixture allowed to warm to r.t. After 30 min full conversion observed. Reaction mixture was poured into water and extracted with EtOAct. The organic layer was dried over magnesium sulfate, filtered and concentrated to give crude azide product. 
     Newly formed azide (338 mg, 1.78 mmol), propiolic acid (186 mg, 2.65 mmol), cuprous iodide (67 mg, 0.35 mmol), sodium ascorbate (140 mg, 0.71 mmol), 1,8-Diazabicyclo[5.4.0]undec-7-ene 1,8-Diazabicyclo[5.4.0]undec-7-ene (0.13 mL, 0.88 mmol) were all combined in DMF (5 mL) and degassed with argon. The reaction mixture was heated to 100° C. for 15 h after which it was diluted with EtOAc, washed with water, brine and dried over magnesium sulfate. The crude product was purified via silica gel chromatography (eluent: EtOAc/hexanes) to yield the product. 
     Ester (79 mg, 0.36 mmol) was dissolved in THF (5 mL) and brought to 0° C. after which lithium aluminum hydride (1.0M in Et 2 O, 0.36 mL, 0.36 mmol) was added dropwise. After 30 minutes the reaction contents were carefully quenched by the addition of water and extracted with EtOAc. The organic extract was washed with brine, dried over magnesium sulfate, filtered and concentrated. The newly formed alcohol was then taken up in DCM (5 mL) and manganese (IV) oxide (790 mg, 9.1 mmol) was added and the reaction stirred for 1 h at room temperature. The reaction contents were filtered through a pad of celite and concentrated to yield the aldehyde product. 
     Example 52 Procedure 52 
     
       
         
         
             
             
         
       
     
     Aniline (500 mg, 3.03 mmol) and sodium azide (364 mg, 5.6 mmol) were dissolved in acetic acid (10 mL) followed by triethyl orthoformate (2.4 mL, 14.5 mmol). The reaction mixture was stirred at room temperature for 15 h then at 100° C. for 3 h. The reaction contents were concentrated directly and purified via silica gel chromatography (eluent: EtOAc/hexanes) to yield the product. 
     Ester (290 mg, 1.3 mmol) was dissolved in THF (10 mL) and brought to 0° C. after which lithium aluminum hydride (1.0M in Et 2 O, 1.3 mL, 1.3 mmol) was added dropwise. After 30 minutes the reaction contents were carefully quenched by the addition of water and extracted with EtOAc. The organic extract was washed with brine, dried over magnesium sulfate, filtered and concentrated. The newly formed alcohol was then taken up in DCM (10 mL) and DMF (2 mL) and manganese (IV) oxide (2.65 g, 30 mmol) was added and the reaction stirred for 1 h at room temperature. The reaction contents were filtered through a pad of celite and concentrated to yield the aldehyde product. 
     Example 53 Procedure 53 
     
       
         
         
             
             
         
       
     
     Bromide (300 mg, 1.5 mmol), stannane (0.46 mL, 1.5 mmol) and Pd(PPh 3 ) 4  were combined in DMF (4 mL) and heated to 160° C. for 15 minutes. The reaction contents were then diluted with EtOAc, washed with water, brine and dried over magnesium sulfate. The crude product was purified via silica gel chromatography (eluent: EtOAc/hexanes) to yield the desired aldehyde. 
     Example 54 Procedure 54 
     
       
         
         
             
             
         
       
     
     Starting material (30 mg, 0.06 mmol) was dissolved in DCM (1.5 mL) after which diisopropylethylamine (0.03 mL, 0.18 mmol) and chloromethyl chloroformate (9.2 mg, 0.07 mmol) were added and the resulting mixture stirred for 30 min. Chloromethyl chloroformate (154 mg, 1.2 mmol) was then added and the reaction mixture stirred for an additional 1 h. Upon completion the reaction was concentrated directly and purified via silica gel chromatography (eluent: EtOAc/hexanes) to yield the desired chloride. 
     The resulting chloride (34 mg, 0.057 mmol) was combined with ditert-butyl phosphate, potassium salt (28 mg, 0.11 mmol) and tetrabutylammonium iodide (2.0 mg, 0.006 mmol) and stirred at 60° C. for 12 h. The reaction contents were then diluted with EtOAc, washed with water, brine and dried over magnesium sulfate. The crude product was purified via silica gel chromatography (eluent: EtOAc/hexanes) to yield the desired product. 
     Starting material (28 mg, 0.036 mmol) was dissolved in acetic acid (0.5 mL), water (0.5 mL), acetonitrile (0.5 mL) and heated to 50° C. for 6 h. Upon completion the reaction mixture was directly purified via RP-HPLC. The product fractions were combined and subjected to lyophilization, providing the desired compound as TFA salt. 
     Example 55 Procedure 55 
     
       
         
         
             
             
         
       
     
     Boc amine (39 mg, 0.059 mmol) was taken up in DCM (1 mL) and trifluoroacetic acid (1 mL) and stirred for 2 h at room temperature. The reaction mixture was concentrated to dryness, taken up in THF (1 mL) and treated with sodium cyanoborohydride (37 mg, 0.59 mmol) and cyclopropyl mixed ketal (102 mg, 0.59 mmol) at room temperature overnight. The reaction contents were then diluted with EtOAc, washed with water, brine, dried over magnesium sulfate and purified by RP-HPLC. The product fractions were combined and subjected to lyophilization, providing the desired compound as TFA salt. 
     Example 56 Procedure 56 
     
       
         
         
             
             
         
       
     
     Iodide (50 mg, 0.074 mmol), stannane (269 mg, 0.74 mmol), and catalyst (27 mg, 0.037 mmol) were combined in DMF (1 mL), degassed with argon, and heated to 100° C. for 12 h. The reaction contents were then filtered through a pad of celite, rinsing with EtOAc, and concentrated. The crude product mixture was taken up in methanol (1 mL) and 1N HCl (1 mL) and stirred at room temperature for 15 h. The reaction contents were poured into saturated aqueous NaHCO 3  solution and extracted with EtOAc. The organic layers were dried over magnesium sulfate, filtered, concentrated and purified by RP-HPLC. The product fractions were combined and subjected to lyophilization, providing the desired ketone as TFA salt (4.9 mg, 11%) as well as the dehalogenated product. 
     Example 57 Procedure 57 
     
       
         
         
             
             
         
       
     
     A solution of (S)-6-(((4-fluorophenyl)(1-(1-(pyrazin-2-yl)cyclopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-8-iodo-4-(neopentylamino)quinoline-3-carbonitrile (26.9 mg, 0.040 mmol), copper (I) cyanide (10.7 mg, 0.12 mmol) in dimethylformamide (1 mL) was heated in a microwave reactor at 140 C for 15 min. The mixture was diluted with ethyl acetate (10 ml) and washed with 5% lithium chloride (2×5 mL) and brine (5 mL). The organic phase was dried over sodium sulfate and the solvent was removed under reduced pressure. The residue was taken up in water (0.5 ml) and MeOH (1 mL) with 2 drops of TFA and subjected to prep HPLC. The clean fractions combined and subjected to lyophilization, providing the desired material. 
     Example 58 Procedure 58 
     
       
         
         
             
             
         
       
     
     (S)-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-8-(methylsulfonyl)-4-(neopentylamino)quinoline-3-carbonitrile 
     To (S)-6-(((1-cyclopropyl-1H-1,2,3-triazol-4-yl)(4-fluorophenyl)methyl-d)amino)-8-iodo-4-(neopentylamino)quinoline-3-carbonitrile (50 mg, 0.084 mmol) was added L-proline (1.9 mg, 0.017 mmol), Cu(I) iodide (1.6 mg, 0.008 mmol), sodium methanesulfinate (10 mg, 0.101 mmol), cesium carbonate (27 mg, 0.084 mmol) and DMSO (0.5 mL). The reaction mixture was flushed with nitrogen and heated to 83° C. overnight. Reaction was then cooled to room temperature and diluted with water and EtOAc. Aqueous layer was extracted once more with EtOAc. Combined organics were washed with water, brine, dried (Na 2 SO 4 ) and concentrated to give the crude product which was purified by HPLC (eluent: water/MeCN*0.1% TFA) to yield the title product. ES/MS 549.43 (M+H + ). 
     Example 59 Procedure 59 
     
       
         
         
             
             
         
       
     
     (S)-8-chloro-6-(((2-chloro-6-fluorophenyl)(1-(1-methylcyclopropyl)-1H-1,2,3-triazol-4-yl-5-d)methyl-d)amino)-4-(neopentylamino)quinoline-3-carbonitrile 
     A solution of (R)-8-chloro-6-((1-(2-chloro-6-fluorophenyl)prop-2-yn-1-yl-1-d)amino)-4-(neopentylamino)quinoline-3-carbonitrile (55 mg, 0.121 mmol) in deuterated methanol (CD 3 OD, 2.5 mL) was treated with the azide (14 mg, 0.145 mmol) and copper(I)thiophenecarboxylate (0.7 mg, 0.006 mmol) at room temperature. After 12 hours, the reaction was diluted with EtOAc and filtered through celite. The crude was purified by silica gel chromatography (eluent: EtOAc:hexanes) followed by HPLC purification(eluent: water/MeCN*0.1% TFA) to yield the title product. ES/MS 554.32 (M+H + ). 
     Example 60 Procedure 60 
     
       
         
         
             
             
         
       
     
     (S)-8-chloro-6-(((2-chlorophenyl)(5-iodo-1-(1-methylcyclopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-4-(neopentylamino)quinoline-3-carbonitrile 
     To a solution of (S)-8-chloro-6-(((2-chlorophenyl)(5-methoxy-1-(1-methylcyclopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-4-(neopentylamino)quinoline-3-carbonitrile (430 mg, 0.98 mmol) in THF were added copper (I) iodide (37.4.5 mg, 0.906 mmol) and N-iodo morpholine hydroiodide (402 mg, 1.2 mmol). After 14 hrs, the reaction was diluted with EtOAc, washed with sodium bicarbonate solution and dried over sodium sulfate. Filtration and removal of volatiles yielded crude solid, which was used in the next step without further purification. To a solution of the starting material and copper iodide (20 mg, 0.1 mmol) in DMF (3 mL) was added cyclopropyl azide (97 mg 1.0 mmol), and triethylamine (101 mg, 1.0 mmol). After 16 h the reaction was diluted with ethyl acetate (5 mL). The product 190 mg) was isolated as a precipitate via filtration. 
     
       
         
         
             
             
         
       
     
     (S)-8-chloro-6-(((2-chlorophenyl)(5-fluoro-1-(1-methylcyclopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-4-(neopentylamino)quinoline-3-carbonitrile 
     Acetonitrile (4.0 mL) and water (4.0 mL) were added to (S)-8-chloro-6-(((2-chlorophenyl)(5-iodo-1-(1-methylcyclopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-4-(neopentylamino)quinoline-3-carbonitrile (190 mg, 0.288 mmol) and KHF 2  (157.3 mg, 2.014 mmol) in a microwave vial. The vial was sealed and the reaction was heated in a microwave reactor at 180° C. for 10 minutes. The reaction was diluted with ethyl acetate (10 mL) and washed with brine (5 mL). The organic phase was dried over sodium sulfate and the solvent was removed under reduced pressure. The residue was subjected to flash chromatography (0-100% ethyl acetate/hexanes). The fractions containing product were combined and the solvent was removed under reduced pressure. The residue was taken up in methanol and water and subjected to preparative HPLC. The clean fractions were combined and subjected to lyophilization, providing (S)-8-chloro-6-(((2-chlorophenyl)(5-fluoro-1-(1-methylcyclopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-4-(neopentylamino)quinoline-3-carbonitrile. 
     Example 61 Procedure 61 
     
       
         
         
             
             
         
       
     
     (S)-8-chloro-6-(((2-chlorophenyl)(5-methoxy-1-(1-methylcyclopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-4-(neopentylamino)quinoline-3-carbonitrile 
     Sodium methoxide (28 uL, 25% MeOH) was added to a solution of (S)-8-chloro-6-(((2-chlorophenyl)(5-fluoro-1-(1-methylcyclopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-4-(neopentylamino)quinoline-3-carbonitrile (72 mg, 0.13 mmol) in tetrahydrofuran (3.0 mL). The solution was heated at 90° C. for 3 hours and the reaction was quenched with 2 drops of acetic acid. The solution was diluted with ethyl acetate and washed with saturated sodium bicarbonate) and brine. The organic phase was dried over sodium sulfate and the solvent was removed under reduced pressure. The residue was subjected to flash chromatography (0-100% ethyl acetate/hexanes). The fractions containing product were combined and the solvent was removed under reduced pressure. The residue was taken up in methanol/water and was subjected to preparative HPLC. The clean fractions containing product were combined and subjected to lyophilization, providing (S)-8-chloro-6-(((2-chlorophenyl)(5-methoxy-1-(1-methylcyclopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-4-(neopentylamino)quinoline-3-carbonitrile. 
     Example 62 Procedure 62 
     
       
         
         
             
             
         
       
     
     (S)-8-chloro-6-(((2-methyl-3-(1H-pyrazol-4-yl)phenyl)(1-(1-(trifluoromethyl)cyclopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-4-(neopentylamino)quinoline-3-carbonitrile 
     (S)-6-(((3-bromo-2-methylphenyl)(1-(1-(trifluoromethyl)cyclopropyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-8-chloro-4-(neopentylamino)quinoline-3-carbonitrile (50 mg, 0.077 mmol), [1 1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (9.4 mg, 0.015 mmol), 1-Boc-pyrazole-4-boronic acid pinacol ester (27 mg, 0.093 mmol) and cesium carbonate (76 mg, 0.23 mmol) were combined in DMF (1.5 mL) and purged with argon. The reaction mixture was heated to 180° C. for 20 minutes in a microwave reactor. After passing the reaction mixture through a silica-thiol plug the solvents were removed and the crude residue purified by RP-HPLC (eluent: water/MeCN*0.1% TFA) to yield the product as trifluoro acetate salt. Note: This procedure can be carried out with an iodide in place of the bromide. 
     The following compounds were prepared according to the Examples and Procedures described herein (and indicated in Table 1 under Example/Procedure) using the appropriate starting material(s) and appropriate protecting group chemistry as needed. 
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 1 
               
               
                   
               
               
                   
                   
                   
                 Exam- 
                   
               
               
                   
                   
                   
                 ple/ 
                   
               
               
                   
                   
                   
                 Pro- 
                 ES/MS 
               
               
                 Compd 
                 Structure 
                 Name 
                 cedure 
                 m/z 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1- cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 505.1 (M + H+) 
               
               
                   
               
               
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1- cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-4-(((R)-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 2 
                 ES/MS 553.2 (M + H+) 
               
               
                   
               
               
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1- cyclopropyl- 1H-1,2,3-triazol-4-yl)(o- tolyl)methyl)amino)-4- (neopentylamino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 500.2 (M + H+) 
               
               
                   
               
               
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(4-(((8-chloro-3- cyano-4-(neopentylamino) quinolin-6- yl)amino)(2-chlorophenyl) methyl-d)-1H-1,2,3- triazol-1-yl)acetamide 
                 4 
                 ES/MS 538.2 (M + H+) 
               
               
                   
               
               
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3- chloro-4-fluorophenyl)amino)- 6-(((1-(1-ethylpiperidin-4- yl)-1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl) amino)quinoline- 3-carbonitrile 
                 5 
                 ES/MS 633.1 (M + H+) 
               
               
                   
               
               
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)- 6-(((4-chlorophenyl)(1- (1-ethylpiperidin- 4-yl)-1H-1,2,3-triazol-4- yl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                   
               
               
                   
               
               
                 7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(isoxazol-3- yl)methyl)amino)quinoline-3- carbonitrile 
                 7 
                 ES/MS 522.1 (M + H+) 
               
               
                   
               
               
                 8  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-bromo-4-((3-chloro- 4-fluorophenyl)amino)- 6-(((4-fluorophenyl) (1-methyl-1H-1,2,3- triazol-4- yl)methyl)amino) quinoline-3-carbonitrile 
                 8 
                 ES/MS 580.1 (M + H+) 
               
               
                   
               
               
                 9 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(3-((1-cyclopropyl- 1H-1,2,3- triazol-4-yl)((3,8- dicyano-4- (neopentylamino) quinolin-6- yl)amino)methyl)phenyl)- N-methylacetamide 
                 9a 
                 ES/MS 548.1 (M + H+) 
               
               
                   
               
               
                 10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin-4-yl)-1H-1,2,3- triazol-4-yl)(phenyl) methyl)amino)-8- chloro-4-((5-chloro-6- fluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 644.2 (M + H+) 
               
               
                   
               
               
                 11  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-acetyl-6-(((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4- (neopentylamino) quinoline-3-carbonitrile 
                 11 
                 ES/MS 513.3 (M + H+) 
               
               
                   
               
               
                 12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-4- (neopentylamino)- 8-(pyrimidin-5- yl)quinoline-3-carbonitrile 
                 12 
                 ES/MS 549.3 (M + H+) 
               
               
                   
               
               
                 13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-bromo-6-(((1- cyclopropyl-5- (methylthio)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4- (neopentylamino) quinoline-3-carbonitrile 
                 13 
                 ES/MS 595.2 (M + H+) 
               
               
                   
               
               
                 14  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-acetyl-6-(((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4-yl) methyl-d)amino)- 4-(neopentylamino) quinoline-3-carbonitrile 
                 14 
                 ES/MS 529.2 (M + H+) 
               
               
                   
               
               
                 15  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(3- cyanophenyl)(1H-1,2,3- triazol-4-yl)methyl-d) amino)-4-(((R)-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 520.0 (M + H+) 
               
               
                   
               
               
                 16  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(6-(((1-(1-(tert- butyl)piperidin-4-yl)- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl) amino)-8-chloro-3- cyanoquinolin-4- yl)benzamide 
                 16 
                 ES/MS 637.2 (M + H+) 
               
               
                   
               
               
                 17  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin-4-yl)-1H-1,2,3- triazol-4-yl)(3- (hydroxymethyl)phenyl) methyl)amino)-8-chloro- 4-((3-chloro-4- fluorophenyl)amino) quinoline-3-carbonitrile 
                 17 
                 ES/MS 673.1 (M + H+) 
               
               
                   
               
               
                 18  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin-4-yl)-1H-1,2,3- triazol-4-yl)(3- ((dimethylamino)methyl) phenyl)methyl)amino)-8- chloro-4-((3-chloro- 4-fluorophenyl)amino) quinoline-3-carbonitrile 
                 18 
                 ES/MS 700.2 (M + H+) 
               
               
                   
               
               
                 19  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-((1-(1-(tert-butyl) piperidin-4-yl)-1H-1,2,3- triazol-4-yl)((8- chloro-4-((3-chloro-4- fluorophenyl)amino)-3- cyanoquinolin-6- yl)amino)methyl)benzoic  acid 
                 19 
                 ES/MS 687.0 (M + H+) 
               
               
                   
               
               
                 20  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-((1-(1-(tert-butyl) piperidin-4-yl)-1H-1,2,3- triazol-4-yl)((8- chloro-4-((3-chloro-4- fluorophenyl)amino)-3- cyanoquinolin-6-yl) amino)methyl)- N,N-dimethylbenzamide 
                 20 
                 ES/MS 714.0 (M + H+) 
               
               
                   
               
               
                 21  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-acetylphenyl) (1-(1-(tert-butyl) piperidin-4-yl)-1H-1,2,3- triazol-4-yl)methyl) amino)-8-chloro-4-((3- chloro-4-fluorophenyl) amino)quinoline-3- carbonitrile 
                 21 
                 ES/MS 685.1 (M + H+) 
               
               
                   
               
               
                 22  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((1S)-(1-(1-(tert-butyl) piperidin-4-yl)-1H-1,2,3- triazol-4-yl)(3-(1- hydroxyethyl)phenyl)methyl) amino)-8-chloro-4-((3- chloro-4-fluorophenyl) amino)quinoline-3- carbonitrile 
                 22 
                 ES/MS 687.2 (M + H+) 
               
               
                   
               
               
                 23  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin-4-yl)-1H-1,2,3- triazol-4-yl)(3-(oxazol-2- yl)phenyl)methyl)amino)- 8-chloro-4-((3-chloro-4- fluorophenyl)amino) quinoline-3-carbonitrile 
                 23 
                 ES/MS 710.1 (M + H+) 
               
               
                   
               
               
                 24  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-aminophenyl) (1-(1-(tert- butyl)piperidin-4-yl)- 1H-1,2,3- triazol-4-yl)methyl) amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino) quinoline-3-carbonitrile 
                 24 
                 ES/MS 658.0 (M + H+) 
               
               
                   
               
               
                 25  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(3-((1-(1-(tert- butyl)piperidin-4-yl)- 1H-1,2,3- triazol-4-yl)((8-chloro- 4-((3-chloro- 4-fluorophenyl)amino)-3- cyanoquinolin-6- yl)amino)methyl)phenyl) methanesulfonamide 
                 25 
                 ES/MS 736.0 (M + H+) 
               
               
                   
               
               
                 26 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-(1,1-difluoro-2- hydroxyethyl)-1H- 1,2,3-triazol-4-yl) methyl-d)amino)- 4-(neopentylamino) quinoline-3-carbonitrile 
                 26 
                 ES/MS 561.1 (M + H+) 
               
               
                   
               
               
                 27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6- (((1-(1-ethylpiperidin- 4-yl)-1H-imidazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 27  
                 ES/MS 613.9 (M + H+) 
               
               
                   
               
               
                 28  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4- (neopentylamino)-8- (pyridin-2-yl) quinoline-3-carbonitrile 
                 28 
                 ES/MS 548.2 (M + H+) 
               
               
                   
               
               
                 29  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-8-(1-hydroxyethyl)-4- (neopentylamino) quinoline-3-carbonitrile 
                 29  
                 ES/MS 515.3 (M + H+) 
               
               
                   
               
               
                 30  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-8-ethynyl-4-(((R)-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 30 
                 ES/MS 543.3 (M + H+) 
               
               
                   
               
               
                 31  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3- chloro-4-fluorophenyl) amino)-6-(((4- fluorophenyl)(1-(1- (oxetan-3-yl)piperidin- 4-yl)-1H-1,2,3-triazol- 4-yl)methyl)amino) quinoline-3-carbonitrile 
                 31 
                 ES/MS 661.1 (M + H+) 
               
               
                   
               
               
                 32  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl) amino)-4-(((R)-3-fluoro-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 32 
                 ES/MS 570.1 (M + H+) 
               
               
                   
               
               
                 33     
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N-(8-chloro-3-cyano-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4- yl)(4-fluorophenyl) methyl-d)amino) quinolin-4-yl)pivalamide 
                 33 
                 ES/MS 519.3 (M + H+) 
               
               
                   
               
               
                 34  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4- (((R)-3-morpholino-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 34 
                 ES/MS 638.0 (M + H+) 
               
               
                   
               
               
                 35  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)- 6-(((4-fluorophenyl) (1-(1-(2-methoxyethyl) piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)methyl)amino) quinoline-3-carbonitrile 
                 35 
                 ES/MS 663.3 (M + H+) 
               
               
                   
               
               
                 36  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((3-cyanophenyl) (1-cyclopropyl-1H-1,2,3- triazol-4-yl)methyl- d)amino)-5-fluoro-4- (((R)-1-phenylpropyl) amino)quinoline-3- carbonitrile 
                 36 
                 ES/MS 578.0 (M + H+) 
               
               
                   
               
               
                 37  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(3- cyanophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-5-yl) methyl-d)amino)- 4-(((R)-1-phenylpropyl)amino) quinoline-3-carbonitrile 
                 37 
                 ES/MS 560.1 (M + H+) 
               
               
                   
               
               
                 38  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin-4-yl)- 1H-1,2,3-triazol-4-yl)(3- (methoxymethyl)phenyl) methyl)amino)- 8-chloro-4-((3-chloro-4- fluorophenyl)amino) quinoline-3-carbonitrile 
                 38 
                 ES/MS 687.2 (M + H+) 
               
               
                   
               
               
                 39  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 methyl (S)-3-((1-(1-(tert- butyl)piperidin-4-yl)-1H- 1,2,3-triazol-4-yl) ((8-chloro-4-((3-chloro- 4-fluorophenyl)amino)-3- cyanoquinolin-6- yl)(methyl)amino)methyl) benzoate 
                 39 
                 ES/MS 715.1 (M + H+) 
               
               
                   
               
               
                 40  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3- chloro-4-fluorophenyl) amino)-6-(((3-((2- (dimethylamino)ethoxy) methyl)phenyl) (1-isopropyl-1H-1,2,3- triazol-4-yl)methyl)amino) quinoline-3-carbonitrile 
                 40 
                 ES/MS 647.0 (M + H+) 
               
               
                   
               
               
                 41  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-(((8-chloro-4-((3- chloro-4- fluorophenyl)amino)-3- cyanoquinolin-6-yl) amino)(1-(1- ethylpiperidin-4-yl)- 1H-1,2,3-triazol-4-yl)methyl)- N,N-dimethylbenzamide 
                 41 
                 ES/MS 685.9 (M + H+) 
               
               
                   
               
               
                 42  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin-4-yl)- 1H-1,2,3-triazol-4-yl)(3- formylphenyl)methyl) amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino) quinoline-3-carbonitrile 
                 42 
                 ES/MS 671.4 (M + H+) 
               
               
                   
               
               
                 43  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-8-hydroxy-4- (neopentylamino) quinoline-3-carbonitrile 
                 43 
                   
               
               
                   
               
               
                 44  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl) amino)-6-(((1- (fluoromethyl)-1H- 1,2,3-triazol-4- yl)(4-fluorophenyl) methyl-d)amino) quinoline-3-carbonitrile 
                 44 
                 ES/MS 540.1 (M + H+) 
               
               
                   
               
               
                 45  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl) amino)-6-(((2- fluorophenyl)(1-methyl- 1H-1,2,3-triazol-4- yl)methyl)amino) quinoline-3-carbonitrile 
                 45 
                 ES/MS 521.1 (M + H+) 
               
               
                   
               
               
                 46  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((1S)-(1-(4-(tert- butylamino)-3- hydroxybutyl)-1H- 1,2,3-triazol-4-yl) (4-fluorophenyl)methyl- d)amino)-8-chloro-4- (((R)-1-phenylpropyl) amino)quinoline-3-carbonitrile 
                 46 
                 ES/MS 656.3 (M + H+) 
               
               
                   
               
               
                 47  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((R)-3- cyano-1-phenylpropyl) amino)-6-(((1-(1- cyanocyclopropyl)- 1H-1,2,3-triazol-4-yl)(3- cyanophenyl)methyl- d)amino)quinoline-3- carbonitrile 
                 4 
                 ES/MS 610.2 (M + H+) 
               
               
                   
               
               
                 48  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(4-((S)-((8-chloro- 3-cyano-4- (((R)-3-cyano-1- phenylpropyl)amino) quinolin-6- yl)amino)(phenyl) methyl)-1H- 1,2,3-triazol-1-yl)-2,2- difluoroacetic acid 
                 2 
                   
               
               
                   
               
               
                 49  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(2- chlorophenyl)(1-(1- cyanocyclopropyl)-1H- 1,2,3-triazol-4-yl) methyl)amino)-4-(((R)- 1-phenylpropyl)amino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 593.1 (M + H+) 
               
               
                   
               
               
                 50  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((1-(1- cyanocyclopropyl)- 1H-1,2,3- triazol-4-yl)(3- cyanophenyl)methyl- d)amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 537.2 (M + H+). 
               
               
                   
               
               
                 51  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((R)-3-cyano-1- phenylpropyl)amino)- 6-(((S)-(3-cyanophenyl) (1-(1,1-difluoro-2- hydroxyethyl)-1H- 1,2,3-triazol-4- yl)methyl-d)amino) quinoline-3-carbonitrile 
                 26 
                 625.2 
               
               
                   
               
               
                 52  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-bromo-6-(((1- cyclopropyl- 1H-1,2,3-triazol-4-yl) (3-(3-hydroxyazetidine-1- carbonyl)phenyl) methyl)amino)-4- (neopentylamino) quinoline-3-carbonitrile 
                 20  
                 ES/MS 629.2 (M + H+) 
               
               
                   
               
               
                 53  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-bromo-6-(((1- cyclopropyl- 1H-1,2,3-triazol-4- yl)(3-(3- fluoroazetidine-1- carbonyl)phenyl)methyl) amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 20 
                 ES/MS 631.2 (M + H+) 
               
               
                   
               
               
                 54  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-(((8-bromo-3- cyano-4-(neopentylamino) quinolin-6-yl)amino) (1-cyclopropyl-1H- 1,2,3-triazol-4-yl) methyl)benzamide 
                 20 
                 ES/MS 573.1 (M + H+) 
               
               
                   
               
               
                 55  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-((1-cyclopropyl- 1H-1,2,3-triazol-4-yl) ((3,8-dicyano-4- (neopentylamino) quinolin-6-yl) amino)methyl)-N- methylbenzamide 
                 20 
                 ES/MS 534.1 (M + H+) 
               
               
                   
               
               
                 56  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3-triazol- 4-yl)(3-(3,3- difluoroazetidine-1- carbonyl)phenyl)methyl) amino)-4-(neopentylamino) quinoline-3,8-dicarbonitrile 
                 20 
                 ES/MS 596.1 (M + H+) 
               
               
                   
               
               
                 57  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl) (3-(3-hydroxyazetidine- 1-carbonyl)phenyl) methyl)amino)- 4-(neopentylamino) quinoline-3,8-dicarbonitrile 
                 20 
                 ES/MS 576.0 (M + H+) 
               
               
                   
               
               
                 58  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3- triazol-4-yl)(3-(3- fluoroazetidine-1- carbonyl)phenyl)methyl) amino)-4-(neopentylamino) quinoline-3,8-dicarbonitrile 
                 20 
                 ES/MS 578.1 (M + H+) 
               
               
                   
               
               
                 59  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-((1-cyclopropyl- 1H-1,2,3-triazol-4-yl) ((3,8-dicyano-4- (neopentylamino) quinolin-6-yl)amino) methyl)benzamide 
                 20 
                 ES/MS 520.1 (M + H+) 
               
               
                   
               
               
                 60  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-(((8-bromo-3- cyano-4-(neopentylamino) quinolin-6-yl)amino) (1-cyclopropyl-1H- 1,2,3-triazol-4-yl) methyl)benzoic acid 
                 19 
                 ES/MS 574.6 (M + H+) 
               
               
                   
               
               
                 61  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-allyl-1H-1,2,3- triazol-4-yl) (3-cyanophenyl)methyl- d)amino)-8-chloro-4- (((R)-1-phenylpropyl) amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 560.2 (M + H+) 
               
               
                   
               
               
                 62  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-8- (2-methylpyrimidin-5- yl)-4-(neopentylamino) quinoline-3-carbonitrile 
                 12 
                 ES/MS 563.3 (M + H)+  
               
               
                   
               
               
                 63  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-4-(neopentylamino)- 8-(oxazol-5- yl)quinoline-3-carbonitrile 
                 12 
                 ES/MS 538.3 (M + H)+  
               
               
                   
               
               
                 64  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1- cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-4-((2,2- dimethyltetrahydro- 2H-pyran-4-yl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 547.2 (M + H)+  
               
               
                   
               
               
                 65  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(2- chlorophenyl)(1-(oxetan- 3-yl)-1H-3-triazol- 4-yl)methyl)amino)-4- (((R)-3-cyano-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 609.1 (M + H+) 
               
               
                   
               
               
                 66  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(2- chlorophenyl)(1- (cyanomethyl)- 1H-1,2,3-triazol-4- yl)methyl)amino)-4- (((R)-3-cyano- 1-phenylpropyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 592.1 (M + H+) 
               
               
                   
               
               
                 67  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(2- chlorophenyl)(1-(1,1- difluoro-2- hydroxyethyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (((R)-3-cyano- 1-phenylpropyl)amino) quinoline-3-carbonitrile 
                 26 
                 ES/MS 633.1 (M + H+) 
               
               
                   
               
               
                 68  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(3-((1-cyclopropyl- 1H-1,2,3-triazol-4- yl)((3,8-dicyano-4- (neopentylamino) quinolin-6-yl)amino)methyl) phenyl)methanesulfonamide 
                 25 
                 ES/MS 570.1 (M + H+) 
               
               
                   
               
               
                 69  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(3-((1-cyclopropyl- 1H-1,2,3-triazol-4- yl)((3,8-dicyano-4- (neopentylamino) quinolin-6-yl) amino)methyl)phenyl)-N- methylmethanesulfonamide 
                 9a 
                 ES/MS 584.1 (M + H+) 
               
               
                   
               
               
                 70     
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-1-(4-(((8-chloro-3- cyano-4-(neopentylamino) quinolin-6-yl)amino) (2-chlorophenyl)methyl)- 1H-1,2,3-triazol-1-yl) cyclopropane-1-carboxamide 
                 4 
                 ES/MS 564.2 (M + H+)  
               
               
                   
               
               
                 71  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(4-((S)-((8-chloro-3- cyano-4-(((R)-3-cyano-1- phenylpropyl)amino) quinolin-6-yl)amino) (2-chlorophenyl)methyl)- 1H-1,2,3-triazol-1-yl) acetamide 
                 4 
                 ES/MS 610.2 (M + H+) 
               
               
                   
               
               
                 72  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(2- chlorophenyl)(1-(1- methylcyclopropyl)- 1H-1,2,3-triazol-4- yl)methyl)amino)-4- (((R)-3-cyano-1-phenylpropyl) amino)quinoline-3-carbonitrile 
                 4 
                 ES/MS 607.2 (M + H+) 
               
               
                   
               
               
                 73  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(2- chlorophenyl)(1-(1- cyanocyclopropyl)- 1H-1,2,3- triazol-4-yl)methyl) amino)-4-(((R)- 3-cyano-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 618.1 (M + H+) 
               
               
                   
               
               
                 74  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- chlorophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4-yl) methyl-d)amino)- 4-(((R)-3-cyano-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 594.1 (M + H+) 
               
               
                   
               
               
                 75  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4- (neopentylamino)-8- (pyridazin-4-yl)quinoline-3- carbonitrile 
                 12 
                 ES/MS 549.5 (M + H+) 
               
               
                   
               
               
                 76  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(3-((1-cyclopropyl- 1H-1,2,3-triazol-4- yl)((3,8-dicyano-4- (neopentylamino) quinolin-6-yl)amino)methyl) phenyl)acetamide 
                 9a 
                 ES/MS 534.1 (M + H+) 
               
               
                   
               
               
                 77  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((4-chlorophenyl) (1-cyclopropyl- 1H-1,2,3-triazol-4- yl)methyl)amino)-4- (neopentylamino) quinoline-3,8-dicarbonitrile 
                 9a 
                 ES/MS 512.2 (M + H+) 
               
               
                   
               
               
                 78  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(3-(((8-bromo- 3-cyano-4-(neopentylamino) quinolin-6-yl)amino) (1-cyclopropyl- 1H-1,2,3-triazol- 4-yl)methyl)phenyl)-N- methylacetamide 
                 3 
                 ES/MS 601.1 (M + H+) 
               
               
                   
               
               
                 79  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(3-(((8-bromo- 3-cyano-4-(neopentylamino) quinolin-6-yl)amino) (1-cyclopropyl-1H- 1,2,3-triazol-4- yl)methyl)phenyl)acetamide 
                 3 
                 ES/MS 587.9 (M + H+) 
               
               
                   
               
               
                 80  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-bromo-6-(((4- chlorophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4-yl) methyl-d)amino)- 4-(neopentylamino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 565.3 (M + H+) 
               
               
                   
               
               
                 81  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4-(((R)-1- phenylpropyl)amino)-8- (pyrimidin-5-yl)quinoline- 3-carboitrile 
                 12 
                 ES/MS 597.3 (M + H+) 
               
               
                   
               
               
                 82  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3-triazol- 4-yl)(3-(oxazol-2- yl)phenyl)methyl) amino)-4-(neopentylamino) quinoline-3,8-dicarbonitrile 
                 9a 
                 ES/MS 544.1 (M + H+) 
               
               
                   
               
               
                 83  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-bromo-6-(((1- cyclopropyl- 1H-1,2,3-triazol-4-yl) (3-(oxazol-2- yl)phenyl)methyl) amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 597.2 (M + H+) 
               
               
                   
               
               
                 84  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl) (phenyl)methyl- d)amino)-4-(neopentylamino) quinoline-3,8-dicarbonitrile 
                 9a 
                 ES/MS 478.2 (M + H+) 
               
               
                   
               
               
                 85  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-acetyl-6-(((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4-yl) methyl-d)amino)- 4-((3-chlorophenyl) amino)quinoline-3-carbonitrile 
                 14 
                 ES/MS 569.2 (M + H+) 
               
               
                   
               
               
                 86 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(bicyclo[1.1.1] pentan-1-yl)-1H-1,2,3- triazol-4-yl)(2- chlorophenyl)methyl-d) amino)-8-chloro-4- (neopentylamino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 547.4 (M + H+) 
               
               
                   
               
               
                 87  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-cyclopropyl-1H-1,2,3- triazol-4-yl)methyl-d) amino)-4-((3-cyano-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 594.1 (M + H+) 
               
               
                   
               
               
                 88  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-cyclopropyl-1H-1,2,3- triazol-4- yl)methyl-d)amino)-4- ((3-cyano-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 594.1 (M + H+) 
               
               
                   
               
               
                 89  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-cyclopropyl-1H- 1,2,3-triazol-4- yl)methyl-d)amino)- 4-(((R)-3-cyano-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 594.2 (M + H+) 
               
               
                   
               
               
                 90  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-(oxetan-2-ylmethyl)- 1H-1,2,3-triazol-4-yl)methyl-d) amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 551.2 (M + H+) 
               
               
                   
               
               
                 91  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-(1-cyanocyclopropyl)- 1H-1,2,3-triazol-4-yl) methyl-d)amino)-4- (neopentylamino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 546.2 (M + H+) 
               
               
                   
               
               
                 92  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-(3,3,3-trifluoro-2- hydroxypropyl)- 1H-1,2,3-triazol- 4-yl)methyl-d)amino)-4- (neopentylamino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 593.2 (M + H+) 
               
               
                   
               
               
                 93  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-(2,2,2-trifluoroethyl)- 1H-1,2,3-triazol-4- yl)methyl-d)amino)-4- (neopentylamino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 563.2 (M + H+) 
               
               
                   
               
               
                 94  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-[1,1&#39;-biphenyl]- 3-yl(1-cyclopropyl- 1H-1,2,3-triazol-4- yl)methyl)amino)-8- chloro-4-(((R)- 1-phenylpropyl)amino) quinoline-3-carbonitrile 
                 2 
                 ES/MS 610.4 (M + H+) 
               
               
                   
               
               
                 95  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(([1,1&#39;-biphenyl]- 3-yl(1-cyclopropyl- 1H-1,2,3-triazol-4- yl)methyl)amino)-8- chloro-4-(neopentylamino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 562.4 (M + H+) 
               
               
                   
               
               
                 96  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)[1,1&#39;-biphenyl]- 2-yl(1-cyclopropyl- 1H-1,2,3-triazol-4- yl)methyl)amino)-8- chloro-4-(((R)- 1-phenylpropyl)amino) quinoline-3-carbonitrile 
                 2 
                 ES/MS 610.7 (M + H+) 
               
               
                   
               
               
                 97  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(([1,1&#39;-biphenyl]- 2-yl(1-cyclopropyl- 1H-1,2,3-triazol-4- yl)methyl)amino)-8- chloro-4-(neopentylamino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 562.3 (M + H+) 
               
               
                   
               
               
                 98  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-((1R,2S)-2-(trifluoromethyl) cyclopropyl)-1H-1,2,3-triazol- 4-yl)methyl-d)amino)- 4-(neopentylamino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 589.2 (M + H+) 
               
               
                   
               
               
                 99  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-(2,2-difluorocyclopropyl)- 1H-1,2,3-triazol-4-yl)methyl-d) amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 557.2 (M + H+) 
               
               
                   
               
               
                 100  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-((1R,5S,6r)-3-(oxetan- 3-yl)-3-azabicyclo[3.1.0] hexan-6-yl)-1H-1,2,3-triazol- 4-yl)methyl-d)amino)- 4-(neopentylamino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 618.3 (M + H+) 
               
               
                   
               
               
                 101  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2- chloro-6-fluorophenyl) (1-cyclopropyl-1H- 1,2,3-triazol-4-yl)methyl- d)amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 539.2 (M + H+) 
               
               
                   
               
               
                 102  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-8-iodo-4- (neopentylamino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 597.3 (M + H+) 
               
               
                   
               
               
                 103  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-((3-fluorooxetan-3- yl)methyl)-1H- 1,2,3-triazol-4-yl)methyl- d)amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 569.2 (M + H+) 
               
               
                   
               
               
                 104  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-((3-hydroxyoxetan- 3-yl)methyl)- 1H-1,2,3-triazol-4-yl) methyl-d)amino)-4- (neopentylamino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 567.2 (M + H+) 
               
               
                   
               
               
                 105  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-((S)-1-fluoropropan- 2-yl)-1H-1,2,3- triazol-4-yl)methyl-d) amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 541.2 (M + H+) 
               
               
                   
               
               
                 106  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-(1-(trifluoromethyl) cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl- d)amino)- 4-(neopentylamino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 589.2 (M + H+) 
               
               
                   
               
               
                 107  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2- chlorophenyl)(1-(1- methylcyclopropyl)-1H-1,2,3- triazol-4-yl)methyl- d)amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 535.2 (M + H+) 
               
               
                   
               
               
                 108  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-2-(4-(((8-chloro-3-cyano-4- (neopentylamino)quinolin-6- yl)amino)(2-chlorophenyl) methyl-d)-1H-1,2,3- triazol-1-yl)acetic acid 
                 1 
                 ES/MS 539.1 (M + H+) 
               
               
                   
               
               
                 109  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((1-(tert-butyl)-1H- 1,2,3-triazol-4-yl) (2-chlorophenyl)methyl- d)amino)-8-chloro-4- (neopentylamino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 537.2 (M + H+)  
               
               
                   
               
               
                 110  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-2- cyclopropoxyphenyl) amino)-6-(((1- cyclopropyl-1H-1,2,3- triazol-4-yl)(4-fluorophenyl) methyl-d)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 601.0 (M + H+) 
               
               
                   
               
               
                 111  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((R)-((1R,2R)-2- cyanocyclopropyl) (phenyl)methyl) amino)-6-(((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 590.2 (M + H+) 
               
               
                   
               
               
                 112  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((R)-((1S,2S)-2- cyanocyclopropyl) (phenyl)methyl) amino)-6-(((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 590.1 (M + H+) 
               
               
                   
               
               
                 113  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((1-(tert- butyl)cyclopropyl) amino)-8-chloro- 6-(((1-cyclopropyl- 1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 531.1 (M + H+) 
               
               
                   
               
               
                 114  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(2- (hydroxymethyl) phenyl)methyl) amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 17 
                 ES/MS 516.2 (M + H+) 
               
               
                   
               
               
                 115  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(4-((S)-((8-chloro- 3-cyano-4-(((R)-1- phenylpropyl)amino) quinolin-6- yl)amino)(4- fluorophenyl)methyl)- 1H-1,2,3-triazol-1-yl) acetic acid 
                 19 
                   
               
               
                   
               
               
                 116  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-2-(4-(((8-chloro- 4-((3-chloro-4- fluorophenyl)amino)-3- cyanoquinolin-6-yl) amino)(4- fluorophenyl)methyl- d)-1H-1,2,3- triazol-1-yl)acetic acid 
                 19 
                   
               
               
                   
               
               
                 117  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((1R,5S)-bicyclo[3.1.0] hexan-6-yl)amino)- 8-chloro-6-(((S)-(1- cyclopropyl-1H-1,2,3- triazol-4-yl) (4-fluorophenyl)methyl- d)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 515.2 (M + H+) 
               
               
                   
               
               
                 118  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2- chlorophenyl)(1- (oxetan-3-yl)-1H- 1,2,3-triazol-4-yl) methyl-d)amino)-4- (neopentylamino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 537.2 (M + H+) 
               
               
                   
               
               
                 119  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2- chlorophenyl)(1- (cyanomethyl)-1H- 1,2,3-triazol-4-yl) methyl-d)amino)-4- (neopentylamino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 520.2 (M + H+) 
               
               
                   
               
               
                 120  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4- yl)methyl-d)amino)- 4-((2,3-dimethylbutan-2- yl)amino)quinoline- 3-carbonitrile 
                 3 
                 ES/MS 535.0 (M + H+) 
               
               
                   
               
               
                 121  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4- yl)methyl-d)amino)- 4-(((1-methylcyclobutyl) methyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 533.2 (M + H+) 
               
               
                   
               
               
                 122  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(2- (trifluoromethoxy) phenyl)methyl)amino)-4- (neopentylamino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 570.4 (M + H+) 
               
               
                   
               
               
                 123  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2- chlorophenyl)(1- cyclopropyl-1H-1,2,3- triazol-4-yl)methyl-d) amino)-4-((1- methylcyclopropyl) amino)quinolin-3- carbonitrile 
                 3 
                 ES/MS 505.2 (M + H+) 
               
               
                   
               
               
                 124  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((1R,5S,6s)-bicyclo [3.1.0]hexan-6-yl) amino)-8-chloro-6-(((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4-yl) methyl-d)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 531.1 (M + H+) 
               
               
                   
               
               
                 125  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((R)-3- cyano-1-phenylpropyl) amino)-6-(((S)-(3- cyanophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4-yl) methyl-d)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 585.0 (M + H+) 
               
               
                   
               
               
                 126       
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1- cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-4- ((2-(trifluoromethoxy) phenyl) amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 595.1 (M + H+) 
               
               
                   
               
               
                 127  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2- chlorophenyl)(1- cyclopropyl-1H-1,2,3- triazol-4- yl)methyl-d)amino)-4- ((3-cyano-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 594.1 (M + H+) 
               
               
                   
               
               
                 128  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(2-chlorophenyl) (1-cyclopropyl-1H-1,2,3- triazol-4- yl)methyl-d)amino)-4- ((3,3- dimethyltetrahydro-2H- pyran-4- yl)amino)quinoline-3,8- dicarbonitrile 
                 1 
                 ES/MS 554.3 (M + H+) 
               
               
                   
               
               
                 129  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl) (1-(1-(trifluoromethyl) cyclopropyl)-1H- 1,2,3-triazol-4-yl) methyl-d)amino)- 4-(neopentylamino) quinoline-3,8- dicarbonitrile 
                 1 
                 ES/MS 580.2 (M + H+) 
               
               
                   
               
               
                 130  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((4-fluorophenyl) (1-(1-(trifluoromethyl) cyclopropyl)-1H- 1,2,3-triazol-4-yl) methyl-d)amino)- 4-(neopentylamino) quinoline-3,8- dicarbonitrile 
                 1 
                 ES/MS 564.2 (M + H+) 
               
               
                   
               
               
                 131  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(2-chlorophenyl) (1-(1-(trifluoromethyl) cyclopropyl)-1H-1,2,3- triazol-4-yl)methyl-d) amino)- 4-(((R)-1-phenylpropyl) amino)quinoline-3,8- dicarbonitrile 
                 1 
                 ES/MS 628.2 (M + H+) 
               
               
                   
               
               
                 132  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(4-fluorophenyl) (1-(1-(trifluoromethyl) cyclopropyl)- 1H-1,2,3-triazol-4-yl) methyl-d)amino)- 4-(((R)-1-phenylpropyl) amino)quinoline-3,8- dicarbonitrile 
                 1 
                 ES/MS 612.2 (M + H+) 
               
               
                   
               
               
                 133  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 471.1 (M + H+) 
               
               
                   
               
               
                 134  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3- cyano-2,2- dimethylpropyl) amino)-6-(((1- cyclopropyl-1H- 1,2,3-triazol-4- yl)(4-fluorophenyl) methyl-d)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 530.3 (M + H+) 
               
               
                   
               
               
                 135  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-([1,1&#39;- bi(cyclopropan)]-1- ylamino)-8-chloro- 6-(((1-cyclopropyl-1H- 1,2,3-triazol-4- yl)(4-fluorophenyl) methyl-d)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 515.3 (M + H+) 
               
               
                   
               
               
                 136  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((R)- 3-cyano-1- phenylpropyl) amino)-6-(((S)-(3-cyano-2- methylphenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4- yl)methyl-d)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 599.2 (M + H+) 
               
               
                   
               
               
                 137  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-8- (1-methyl-1H- pyrazol-4-yl)-4- (neopentylamino) quinoline-3-carbonitrile 
                 12 
                 ES/MS 551.4 (M + H+) 
               
               
                   
               
               
                 138  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-cyano-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl) (4-fluorophenyl)methyl- d)amino)-N,N-dimethyl-4- (neopentylamino) quinoline-8-carboxamide 
                 1 
                 ES/MS 542.2 (M + H+) 
               
               
                   
               
               
                 139 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-8- (6-fluoropyridin-3- yl)-4-(neopentylamino) quinoline-3-carbonitrile 
                 12 
                 ES/MS 566.2 (M + H+) 
               
               
                   
               
               
                 140  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4- (neopentylamino)- 8-(pyridin-4- yl)quinoline-3-carbonitrile 
                 12 
                 ES/MS 548.2 (M + H+) 
               
               
                   
               
               
                 141  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4-yl) methyl-d)amino)-4-((3,3- dimethyltetrahydro-2H- pyran-4-yl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 563.2 (M + H+) 
               
               
                   
               
               
                 142  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((1R,5S)-3- oxabicyclo[3.1.0]hexan-6- yl)amino)-8-chloro- 6-(((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 517.1 (M + H+) 
               
               
                   
               
               
                 143  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1- cyclopropyl- 1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)-4- (spiro[2.5]octan-1- ylamino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 543.2 (M + H+) 
               
               
                   
               
               
                 144  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((2-(1H- imidazol-2- yl)ethyl)amino)-8- chloro-6-(((1- cyclopropyl-1H- 1,2,3-triazol-4- yl)(4-fluorophenyl) methyl-d)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 529.2 (M + H+) 
               
               
                   
               
               
                 145  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)- (1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4-(((S)-3,3- dimethyltetrahydro-2H- pyran-4-yl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 547.2 (M + H+) 
               
               
                   
               
               
                 146  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)- (1-cyclopropyl- 1H-1,2,3-triazol- yl)(4-fluorophenyl) methyl-d)amino)-4- (((R)-3,3- dimethyltetrahydro-2H- pyran-4-yl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 547.3 (M + H+) 
               
               
                   
               
               
                 147  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4- ((2-(thiazol-2- yl)ethyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 546.3 (M + H+) 
               
               
                   
               
               
                 148  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol- 4-yl)(4- fluorophenyl)methyl- d)amino)-4- ((2-(1-methyl-1H- pyrazol-3-yl)ethyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 543.2 (M + H+) 
               
               
                   
               
               
                 149  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4-((2-(1-methyl- 1H-pyrazol-5- yl)ethyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 543.3 (M + H+) 
               
               
                   
               
               
                 150  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4-((2-(1-methyl-1H- imidazol-2- yl)ethyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 543.2 (M + H+) 
               
               
                   
               
               
                 151  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)- 2-fluoro-4- (neopentylamino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 489.2 (M + H+) 
               
               
                   
               
               
                 152  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl) (1-cyclopropyl-1H- 1,2,3-triazol-4- yl)methyl-d)amino)-4- (neopentylamino) quinoline-3,8- dicarbonitrile 
                 1 
                 ES/MS 512.2 (M + H+) 
               
               
                   
               
               
                 153  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-(bicyclo[1.1.1]pentan- 1-ylamino)-8- chloro-6-(((1- cyclopropyl- 1H-1,2,3-triazol-4- yl)(4-fluorophenyl) methyl-d)amino)quinoline- 3-carbonitrile 
                 3 
                 ES/MS 501.1 (M + H+) 
               
               
                   
               
               
                 154  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)- (1-cyclopropyl- 1H-1,2,3-triazol- 4-yl)(4-fluorophenyl) methyl-d)amino)- 4-(((1R,2R)-2- (trifluoromethyl) cyclopropyl) amino)quinoline- 3-carbonitrile 
                 3 
                 ES/MS 543.0 (M + H+) 
               
               
                   
               
               
                 155  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)- (1-cyclopropyl- 1H-1,2,3-triazol- 4-yl)(4-fluorophenyl) methyl-d)amino)- 4-(((1R,2R)-2- ethylcyclopropyl) amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 503.1 (M + H+) 
               
               
                   
               
               
                 156  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)- (1-cyclopropyl- 1H-1,2,3-triazol- 4-yl)(4-fluorophenyl) methyl-d)amino)- 4-((2,2- dimethylcyclopropyl) amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 503.2 (M + H+) 
               
               
                   
               
               
                 157  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((1-cyclopropyl- 1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-7-fluoro-8- methyl-4- (neopentylamino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 503.2 (M + H+) 
               
               
                   
               
               
                 158  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((1- cyclopropyl-1H- 1,2,3-triazol-4- yl)(4-fluorophenyl) methyl-d)amino)-4- (((S)-2- (methylsulfonyl)-1- phenylethyl)amino) quinoline-3-carbonitrile 
                 2 
                   
               
               
                   
               
               
                 159  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4- ((3-chloro-2- methylphenyl) amino)-6-(((1- cyclopropyl-1H- 1,2,3-triazol-4- yl)(4-fluorophenyl) methyl-d)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 559.2 (M + H+) 
               
               
                   
               
               
                 160  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1- cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)- 4-((2-methoxyphenyl) amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 541.2 (M + H+) 
               
               
                   
               
               
                 161  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((S)- ((1S,2S)-2- cyanocyclopropyl) (phenyl) methyl)amino)-6-(((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 590.2 (M + H+) 
               
               
                   
               
               
                 162  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((S)- ((1R,2R)-2- cyanocyclopropyl) (phenyl) methyl)amino)-6-(((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 590.1 (M + H+) 
               
               
                   
               
               
                 163  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4- ((3-chloro-2- methoxyphenyl) amino)-6-(((1- cyclopropyl-1H- 1,2,3-triazol-4- yl)(4-fluorophenyl) methyl-d)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 575.0 (M + H+) 
               
               
                   
               
               
                 164  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((R)-3-cyano-1- phenylpropyl) amino)-6-(((S)-(3-c yanophenyl)(1- cyclopropyl-1H-1,2,3- triazol-4-yl)methyl- d)amino)- 8-fluoroquinoline-3- carbonitrile 
                 1 
                 ES/MS 569.2 (M + H+) 
               
               
                   
               
               
                 165  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((S)-3-cyano-1- phenylpropyl) amino)-6-(((S)- (3-cyanophenyl) (1-cyclopropyl- 1H-1,2,3-triazol-4-yl) methyl-d)amino)-8- fluoroquinoline-3- carbonitrile 
                 1 
                 ES/MS 569.2 (M + H+) 
               
               
                   
               
               
                 166  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)- 4-(((R)-1-phenyl- 3-(piperidin-1-yl)propyl) amino)quinoline-3-carbonitrile 
                 34 
                 ES/MS 636.4 (M + H+) 
               
               
                   
               
               
                 167  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl) (4-fluorophenyl) methyl-d)amino)-4- (((R)-1-phenyl-3- (pyrrolidin-1- yl)propyl)amino) quinoline-3-carbonitrile 
                 34 
                 ES/MS 622.3 (M + H+) 
               
               
                   
               
               
                 168  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)- 4-(neopentylamino)- 8-(1H-pyrazol-4- yl)quinoline-3-carbonitrile 
                 12 
                 ES/MS 537.2 (M + H+) 
               
               
                   
               
               
                 169  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(4-(3-cyano-6-(((1- cyclopropyl-1H-1,2,3- triazol-4-yl)(4-fluorophenyl) methyl-d)amino)-4- (neopentylamino) quinolin-8- yl)phenyl)acetamide 
                 12 
                 ES/MS 604.3 (M + H+) 
               
               
                   
               
               
                 170  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4- (neopentylamino)-8-(pyridin-3- yl)quinoline-3-carbonitrile 
                 12 
                 ES/MS 548.2 (M + H+) 
               
               
                   
               
               
                 171 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)- 4-(neopentylamino)-8- phenylquinoline- 3-carbonitrile 
                 12 
                 ES/MS 547.2 (M + H+) 
               
               
                   
               
               
                 172 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)- 8-methoxy-4- (neopentylamino) quinoline-3-carbonitrile 
                 1 
                   
               
               
                   
               
               
                 173  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4- ((1-hydroxy-2- methylpropan-2- yl)amino)quinoline- 3-carbonitrile 
                 3 
                 ES/MS 507.0 (M + H+) 
               
               
                   
               
               
                 174  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)- (1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4- (4-hydroxybutan-2-yl) amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 507.2 (M + H+) 
               
               
                   
               
               
                 175  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)- (1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4- ((1-phenylbutan-2- yl)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 567.4 (M + H+) 
               
               
                   
               
               
                 176  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4- (trifluoromethyl) cyclopropyl) methyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 557.1 (M + H+) 
               
               
                   
               
               
                 177  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-(azepan-1- ylamino)-8-chloro- 6-(((1-cyclopropyl-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 532.2 (M + H+) 
               
               
                   
               
               
                 178  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4- (piperidin-1-ylamino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 518.3 (M + H+) 
               
               
                   
               
               
                 179  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4- (pyrrolidin-1- ylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 504.1 (M + H+) 
               
               
                   
               
               
                 180  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)- (1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4-((1-(5,6- difluoropyridin-3- yl)propyl)amino) quinoline-3-carbonitrile 
                 2 
                 ES/MS 590.2 (M + H+) 
               
               
                   
               
               
                 181  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)- 4-(((S)-2-methoxy-1- phenylethyl)amino) quinoline-3- carbonitrile 
                 2 
                 ES/MS 569.2 (M + H+) 
               
               
                   
               
               
                 182  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((3-chloro-4- fluorophenyl) amino)-6-(((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4- yl)methyl-d)amino) quinoline-3,8- dicarbonitrile 
                 1 
                 ES/MS 570.1 (M + H+) 
               
               
                   
               
               
                 183  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2- chlorophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4-yl) methyl-d)amino)- 4-((3,4-dichloro-2- fluorophenyl) amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 613.1 (M + H+) 
               
               
                   
               
               
                 184  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((4- fluorophenyl)(1- methyl-1H-tetrazol- 5-yl)methyl-d)amino)-4- (neopentylamino) quinoline-3-carbonitrile 
                 7 
                 ES/MS 480.2 (M + H+) 
               
               
                   
               
               
                 185  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((R)- cyclopropyl (phenyl)methyl)amino)- 6-(((S)-(1-cyclopropyl-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 565.2 (M + H+) 
               
               
                   
               
               
                 186  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)- (1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4- (((R)-1-hydroxy-3,3- dimethylbutan-2- yl)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 535.3 (M + H+) 
               
               
                   
               
               
                 187  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)- (1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4- (((S)-1-hydroxy-3,3- dimethylbutan- 2-yl)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 535.4 (M + H+) 
               
               
                   
               
               
                 188  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)- (1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4-(((R)-3,3- dimethylbutan-2- yl)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 519.2 (M + H+) 
               
               
                   
               
               
                 189  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)- (1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4- dimethylcyclopentyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 531.3 (M + H+) 
               
               
                   
               
               
                 190  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)- (1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4- ((3,3-dimethyltetrahydro- 2H-pyran- 4-yl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 547.5 (M + H+) 
               
               
                   
               
               
                 191  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4- ((2,2,2-trichloroethyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 565.3 (M + H+) 
               
               
                   
               
               
                 192  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4- ((3-chloro-2,2- dimethylpropyl) amino)-6-(((1- cyclopropyl-1H- 1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 539.3 (M + H+) 
               
               
                   
               
               
                 193  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4- ((2-(methylsulfonyl)- 1-phenylethyl)amino) quinoline-3-carbonitrile 
                 2 
                 ES/MS 617.0 (M + H+) 
               
               
                   
               
               
                 194  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-8-methyl-4- (neopentylamino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 485.3 (M + H+) 
               
               
                   
               
               
                 195  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-cyclopropyl- 1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4- (((R)-1-phenylpropyl) amino)-8- (trifluoromethyl) quinoline-3-carbonitrile 
                 2 
                 ES/MS 587.3 (M + H+) 
               
               
                   
               
               
                 196  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl- 1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl- d)amino)- 4-(neopentylamino)-8- (trifluoromethyl) quinoline-3-carbonitrile 
                 1 
                 ES/MS 539.2 (M + H+) 
               
               
                   
               
               
                 197  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((3-cyano-2-methylphenyl) (1-cyclopropyl- 1H-1,2,3-triazol- 4-yl)methyl-d)amino)-4- (neopentylamino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 526.4 (M + H+) 
               
               
                   
               
               
                 198  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4- (difluoromethyl) cyclobutyl)methyl) amino)quinoline- 3-carbonitrile 
                 3 
                 ES/MS 553.4 (M + H+) 
               
               
                   
               
               
                 199  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4- (((3,3-difluoro-1- methylcyclobutyl) methyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 553.3 (M + H+) 
               
               
                   
               
               
                 200  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4- ((1,1-dioxidothietan-3- yl)amino)quinoline- 3-carbonitrile 
                 3 
                 ES/MS 538.9 (M + H+) 
               
               
                   
               
               
                 201  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4- (oxetan-3-ylamino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 491.1 (M + H+) 
               
               
                   
               
               
                 202  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((R)-2-cyano-1- phenylethyl) amino)-6-(((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3,8- dicarbonitrile 
                 1 
                   
               
               
                   
               
               
                 203  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4- (((1-(difluoromethyl) cyclopropyl)methyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 539.3 (M + H+) 
               
               
                   
               
               
                 204  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4-((3,3- difluorocyclobutyl) amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 526.2 (M + H+) 
               
               
                   
               
               
                 205  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4- ((3,3-dimethylcyclobutyl) amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 517.3 (M + H+) 
               
               
                   
               
               
                 206  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)-4- ((2,3-dichlorophenyl) amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 579.3 (M + H+) 
               
               
                   
               
               
                 207  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((2-chloro-4-fluorophenyl) (1-cyclopropyl-1H- 1,2,3-triazol-4-yl) methyl)amino)- 4-(neopentylamino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 538.3 (M + H+) 
               
               
                   
               
               
                 208  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(4- fluorophenyl)(1-methyl- 1H-1,2,3-triazol- 4-yl)methyl-d)amino)-4- (((R)-1- phenylpropyl)amino) quinoline-3,8-dicarbonitrile 
                 45 
                 ES/MS 518.2 (M + H+) 
               
               
                   
               
               
                 209  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((4- fluorophenyl)(1- methyl-1H-1,2,3- triazol-4-yl)methyl-d) amino)-4-(neopentylamino) quinoline-3,8-dicarbonitrile 
                 45 
                 ES/MS 470.3 (M + H+) 
               
               
                   
               
               
                 210  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(2-chlorophenyl)(1- cyclopropyl-1H- 1,2,3-triazol-4- yl)methyl)amino)-4-(((R)-1- phenylpropyl)amino) quinoline-3,8-dicarbonitrile 
                 1 
                 ES/MS 559.2 (M + H+) 
               
               
                   
               
               
                 211  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(1- cyclopropyl- 1H-1,2,3-triazol-4- yl)methyl)amino)-4- (neopentylamino) quinoline-3,8-dicarbonitrile 
                 1 
                 ES/MS 511.2 (M + H+) 
               
               
                   
               
               
                 212  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-((3,3-difluoro-1- methylcyclobutyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 539.1 (M + H+) 
               
               
                   
               
               
                 213  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4- ((2,3-dimethylbutan-2- yl)amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 519.2 (M + H+) 
               
               
                   
               
               
                 214  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl) methyl-d)amino)-4- ((3-methyloxetan-3- yl)amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 505.2 (M + H+) 
               
               
                   
               
               
                 215  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-(cyclobutylamino)- 6-(((1-cyclopropyl-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 489.1 (M + H+) 
               
               
                   
               
               
                 216  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-((1-ethylcyclopropyl) amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 503.3 (M + H+) 
               
               
                   
               
               
                 217  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((1- cyanocyclopropyl)amino)-6-(((1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 500.1 (M + H+) 
               
               
                   
               
               
                 218  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-((1-ethylcyclobutyl) amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 517.2 (M + H+) 
               
               
                   
               
               
                 219  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-((1-methylcyclobutyl) amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 503.1 (M + H+) 
               
               
                   
               
               
                 220  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- (cyclopropylamino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 475.1 (M + H+) 
               
               
                   
               
               
                 221  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-cyclopropyl-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-8- methyl-4-(((R)-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 12 
                 ES/MS 533.2 (M + H+) 
               
               
                   
               
               
                 222  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- (2-ethyl-2- phenylhydrazinyl)quinoline-3- carbonitrile 
                 1 
                 ES/MS 554.1 (M + H+) 
               
               
                   
               
               
                 223  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-((2,2-dimethylbutyl) amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 519.3 (M + H+) 
               
               
                   
               
               
                 224  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-cyclopropyl-6-(((S)-(1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)-4-(((R)-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 12 
                 ES/MS 559.3 (M + H+) 
               
               
                   
               
               
                 225  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-((3-methoxy-2,2- dimethylpropyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 535.4 (M + H+) 
               
               
                   
               
               
                 226  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(((S)-2- phenylpropyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 553.0 (M + H+) 
               
               
                   
               
               
                 227 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(((R)-1- phenylethyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 539.2 (M + H+) 
               
               
                   
               
               
                 228  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((1R,2S)-2- aminocyclohexyl)amino)-8- chloro-6-(((S)-(1- cyclopropyl-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 532.2 (M + H+) 
               
               
                   
               
               
                 229  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 tert-butyl ((1S,2R)-2-((8- chloro-3-cyano-6-(((S)-(1- cyclopropyl-1H- 1,2,3-triazo1-4-yl)(4- fluorophenyl)methyl- d)amino)quinolin-4- yl)amino)cyclohexyl) carbamate 
                 1 
                 ES/MS 632.3 (M + H+) 
               
               
                   
               
               
                 230  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((1S,2R)-2- aminocyclohexyl)amino)-8- chloro-6-(((S)-(1- cyclopropyl-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 532.2 (M + H+) 
               
               
                   
               
               
                 231   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 tert-butyl ((1R,2S)-2- ((8-chloro-3-cyano-6- (((S)-(1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinolin-4- yl)amino)cyclohexyl)carbamate 
                 1 
                 ES/MS 632.3 (M + H+) 
               
               
                   
               
               
                 232  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-cyclopropyl-6-(((1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 12 
                 ES/MS 511.3 (M + H+) 
               
               
                   
               
               
                 233  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(tert-butyl)-1H-1,2,3- triazol-4-yl)(3-cyanophenyl) methyl-d)amino)-8-chloro-4- (neopentylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 528.2 (M + H+) 
               
               
                   
               
               
                 234  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(((1S,2S)-2-(hydroxymethyl) cyclohexyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 547.3 (M + H+) 
               
               
                   
               
               
                 235  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(((1R,2R)-2-(hydroxymethyl) cyclohexyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 547.3 (M + H+) 
               
               
                   
               
               
                 236  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(((1S,2S)-2- hydroxycyclohexyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 533.3 (M + H+) 
               
               
                   
               
               
                 237  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-((2- (trimethylsilyl)ethyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 535.2 (M + H+) 
               
               
                   
               
               
                 238  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(2- (difluoromethyl)phenyl)methyl- d)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 537.4 (M + H+) 
               
               
                   
               
               
                 239  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3- cyanophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)methyl- d)amino)-4-((2,2- dimethylpropyl-1,1- d2)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 514.4 (M + H+) 
               
               
                   
               
               
                 240  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-cyanophenyl)(1- cyclopropyl-1H-1,2,3-triazol- 4-yl)methyl-d)amino)-4- (neopentylamino)quinoline- 3,8-dicarbonitrile 
                 1 
                 ES/MS 503.2 (M + H+) 
               
               
                   
               
               
                 241  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-((1-methylcyclopropyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 489.3 (M + H+) 
               
               
                   
               
               
                 242  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(bicyclo[3.1.0]hexan-6- ylamino)-8-chloro-6-(((S)- (1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 515.2 (M + H+) 
               
               
                   
               
               
                 243  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(3-cyanophenyl)(1- cyclopropyl-1H-1,2,3-triazol-4- yl)methyl-d)amino)-4-(((R)-1- phenylpropyl)amino)quinoline- 3,8-dicarbonitrile 
                 1 
                 ES/MS 551.2 (M + H+) 
               
               
                   
               
               
                 244  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(((S)-3,3-dimethylbutan-2- yl)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 519.3 (M + H+) 
               
               
                   
               
               
                 245  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((3R,5R,7R)-adamantan-1- yl)amino)-8-chloro-6-(((S)-(1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 569.4 (M + H+) 
               
               
                   
               
               
                 246  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((1S,3S,5S,7S)-adamantan-2- yl)amino)-8-chloro-6-(((S)-(1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 569.2 (M + H+) 
               
               
                   
               
               
                 247  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((R)-1-cyano-3,3- dimethylbutan-2-yl)amino)-6- (((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 544.3 (M + H+) 
               
               
                   
               
               
                 248  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((S)-3-cyano-1- phenylpropyl)amino)-6-(((S)-(1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 578.3 (M + H+) 
               
               
                   
               
               
                 249  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((R)-3-cyano-1- phenylpropyl)amino)-6-(((S)-(1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 578.2 (M + H+) 
               
               
                   
               
               
                 250 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(bicyclo[4.1.0]heptan-2- ylamino)-8-chloro-6-(((S)-(1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 529.3 (M + H+) 
               
               
                   
               
               
                 251  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(bicyclo[3.1.0]hexan-2- ylamino)-8-chloro- 6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 515.3 (M + H+) 
               
               
                   
               
               
                 252  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(tert-butyl)-1H- 1,2,3-triazol-4-yl)(3- cyanophenyl)methyl-d)amino)- 8-chloro-4-(((R)-1- phenylpropyl)amino)quinoline- 3-carbonitrile 
                 2 
                 ES/MS 576.2 (M + H+) 
               
               
                   
               
               
                 253  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(tert-butyl)-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino- 8-chloro-4-(((R)-1- phenylpropyl)amino)quinoline- 3-carbonitrile 
                 2 
                 ES/MS 569.2 (M + H+) 
               
               
                   
               
               
                 254  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-((3-cyano-1- phenylpropyl)amino)-6- (((S)-(3-cyanophenyl) (1-cyclopropyl-1H- 1,2,3-triazo1-4-yl)methyl-d) amino)-8-fluoroquinoline- 3-carbonitrile 
                 1 
                 ES/MS 569.2 (M + H+) 
               
               
                   
               
               
                 255 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-((3-cyano-1- phenylpropyl)amino)-6- (((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)-8-fluoroquinoline-3- carbonitrile 
                 1 
                 ES/MS 562.2 (M + H+) 
               
               
                   
               
               
                 256  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-cyanophenyl)(1- cyclopropyl-1H-1,2,3-triazol-4- yl)methyl-d)amino)-8-fluoro-4- (neopentylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 496.2 (M + H+) 
               
               
                   
               
               
                 257  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(3-cyanophenyl)(1- cyclopropyl-1H-1,2,3-triazol-4- yl)methyl-d)amino)-8-fluoro-4- (((R)-1-phenylpropyl) amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 544.3 (M + H+) 
               
               
                   
               
               
                 258  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(2-chloro-5- cyanophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4-yl) methyl)amino)-4- (((R)-1-phenylpropyl) amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 593.3 (M + H+) 
               
               
                   
               
               
                 259  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((3-cyanophenyl)(1- cyclopropyl-1H-1,2,3-triazol-4- yl)methyl-d)amino)-4-(((R)-3- hydroxy-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 2 
                 ES/MS 576.1 (M + H+) 
               
               
                   
               
               
                 260  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- (((1-cyclopropylcyclobutyl) methyl)amino)quinoline- 3-carbonitrile 
                 3 
                 ES/MS 543.3 (M + H+) 
               
               
                   
               
               
                 261  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- (((1-ethylcyclobutyl) methyl)amino)quinoline- 3-carbonitrile 
                 3 
                 ES/MS 531.4 (M + H+) 
               
               
                   
               
               
                 262  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- (((trimethylsilyl)methyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 521.3 (M + H+) 
               
               
                   
               
               
                 263  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((4-fluorophenyl) (1-(4-methoxybenzyl)- 1H-tetrazol-5- yl)methyl-d)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 7 
                 ES/MS 586.2 (M + H+) 
               
               
                   
               
               
                 264  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(3- (trifluoromethyl)phenyl)methyl) amino)-4-((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 597.1 (M + H+) 
               
               
                   
               
               
                 265  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(3- fluorophenyl)methyl)amino)-4- ((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 547.1 (M + H+) 
               
               
                   
               
               
                 266  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3- chlorophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4-yl) methyl)amino)-4- ((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 563.1 (M + H+) 
               
               
                   
               
               
                 267  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((2-cyano-1- phenylethyl)amino)-6-(((S)-(4- fluorophenyl)(1-(pyridin-3-yl)- 1H-1,2,3-triazol-4-yl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 600.9 (M + H+) 
               
               
                   
               
               
                 268  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- (isopentylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 505.2 (M + H+) 
               
               
                   
               
               
                 269  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-((2-cyclopropylethyl) amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 503.4 (M + H+) 
               
               
                   
               
               
                 270  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-((2-(pyridin-2- yl)ethyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 540.3 (M + H+) 
               
               
                   
               
               
                 271  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- ((2-(pyridin-3- yl)ethyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 540.3 (M + H+) 
               
               
                   
               
               
                 272  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(3- fluorophenyl)methyl)amino)-4- (((R)-1-phenylpropyl) amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 552.2 (M + H+) 
               
               
                   
               
               
                 273  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(3- chlorophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)methyl) amino)-4-(((R)-1- phenylpropyl)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 568.2 (M + H+) 
               
               
                   
               
               
                 274  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3- chlorophenyl)amino)-6-(((3- cyanophenyl)(1-cyclopropyl-1H- 1,2,3-triazol-4-yl)methyl- d)amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 552.2 (M + H+) 
               
               
                   
               
               
                 275  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-2,6- difluorophenyl)amino)-6-(((3- cyanophenyl)(1-cyclopropyl-1H- 1,2,3-triazol-4-yl)methyl- d)amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 588.2 (M + H+) 
               
               
                   
               
               
                 276  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3- cyanophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4-yl) methyl-d)amino)- 4-(((1-methylcyclobutyl) methyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 524.3 (M + H+) 
               
               
                   
               
               
                 277  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((1s,4s)-bicyclo[2.2.2]octan-2- yl)amino)-8-chloro-6-(((S)-(1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 543.2 (M + H+) 
               
               
                   
               
               
                 278  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((1R,5S)-bicyclo[3.3.1] nonan-3- yl)amino)-8-chloro-6-(((S)-(1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 557.3 (M + H+) 
               
               
                   
               
               
                 279  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-amino-8-chloro-6-(((S)-(1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 435.0 (M + H+) 
               
               
                   
               
               
                 280  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-(tert-butoxyamino)-8- chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 507.2 (M + H+) 
               
               
                   
               
               
                 281  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(((R)-1-(m- tolyl)propyl)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 567.2 (M + H+) 
               
               
                   
               
               
                 282  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(tert-pentylamino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 505.2 (M + H+) 
               
               
                   
               
               
                 283  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-(tert-butylamino)-8- chloro-6-(((1- cyclopropyl-1H-1,2,3- triazol-4-yl)(4-fluorophenyl) methyl-d)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 491.2 (M + H+) 
               
               
                   
               
               
                 284  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-4-(neopentylamino) quinoline-3,8-dicarbonitrile 
                 9 
                 ES/MS 496.2 (M + H+) 
               
               
                   
               
               
                 285  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-4-(((R)-1- phenylpropyl)amino) quinoline-3,8-dicarbonitrile 
                 9 
                 ES/MS 544.3 (M + H+) 
               
               
                   
               
               
                 286  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-((2-cyano-1-phenylethyl) amino)-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 8-fluoroquinoline-3-carbonitrile 
                 1 
                 ES/MS 548.2 (M + H+) 
               
               
                   
               
               
                 287  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-bromo-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 549.2 (M + H+) 
               
               
                   
               
               
                 288  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-bromo-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(((R)-1- phenylpropyl)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 597.1 (M + H+) 
               
               
                   
               
               
                 289  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-chloro-3- cyanophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)methyl- d)amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 5 
                 ES/MS 546.2 (M + H+) 
               
               
                   
               
               
                 290  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((1-cyclopropyl-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-8- fluoro-4- (neopentylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 489.2 (M + H+) 
               
               
                   
               
               
                 291  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 8-fluoro-4-(((R)-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 537.2 (M + H+) 
               
               
                   
               
               
                 292  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(2-chloro-3- cyanophenyl)(1-cyclopropyl-1H- 1,2,3-triazol-4-yl)methyl-d) amino)-4-(((R)-1- phenylpropyl)amino)quinoline- 3-carbonitrile 
                 5 
                 ES/MS 594.1 (M + H+) 
               
               
                   
               
               
                 293  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(2,3- dichlorophenyl)methyl)amino)-4- ((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 597.1 (M + H+) 
               
               
                   
               
               
                 294  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(2,3- dichlorophenyl)methyl)amino)- 4-(((R)-1- phenylpropyl)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 602.1 (M + H+) 
               
               
                   
               
               
                 295  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((S)-2-cyano-1- phenylethyl)amino)-6-(((S)-(3- cyanophenyl)(1-cyclopropyl-1H- 1,2,3-triazol-4-yl)methyl- d)amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 571.3 (M + H+) 
               
               
                   
               
               
                 296  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((R)-2-cyano-1- phenylethyl)amino)-6-(((S)-(3- cyanophenyl)(1-cyclopropyl-1H- 1,2,3-triazol-4-yl)methyl- d)amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 571.4 (M + H+) 
               
               
                   
               
               
                 297  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-5-fluoro-6-(((S)-(4- fluorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino-4-(((R)-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 530.0 (M + H+) 
               
               
                   
               
               
                 298  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(2- chlorophenyl)(5-methyl-1H- 1,2,3-triazol-4-yl)methyl- d)amino)-4-(((R)-1- phenylpropyl)amino)quinoline- 3-carbonitrile 
                 7 
                   
               
               
                   
               
               
                 299  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((2-cyano-2- methylpropyl)amino)-6-(((1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 516.2 (M + H+) 
               
               
                   
               
               
                 300  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- (((R)-1-(3- fluorophenyl)propyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 571.2 (M + H+) 
               
               
                   
               
               
                 301  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-(2- cyclohexylhydrazinyl)-6-(((1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 532.2 (M + H+) 
               
               
                   
               
               
                 302  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-cyano-1- phenylpropyl)amino)-6-(((S)-(1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 578.2 (M + H+) 
               
               
                   
               
               
                 303  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5-chloro-6- fluoropyridin-3-yl)amino)-6-(((3- cyanophenyl)(1-cyclopropyl-1H- 1,2,3-triazol-4-yl)methyl- d)amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 571.1 (M + H+) 
               
               
                   
               
               
                 304 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((S)-2-cyano-1- phenylethyl)amino)-6-(((S)-(4- fluorophenyl)(1-isopropyl-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 565.2 (M + H+) 
               
               
                   
               
               
                 305  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((R)-2-cyano-1- phenylethyl)amino)-6-(((S)-(4- fluorophenyl)(1-isopropyl-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 565.2 (M + H+) 
               
               
                   
               
               
                 306  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-((2-fluoro-2-methylpropyl) amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 509.2 (M + H+) 
               
               
                   
               
               
                 307  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-((2,2-dimethyl-1- phenylpropyl)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 581.2 (M + H+) 
               
               
                   
               
               
                 308  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-((3-hydroxy-2,2- dimethylpropyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 521.2 (M + H+) 
               
               
                   
               
               
                 309  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((2- cyanoethyl)amino)-6-(((1- cyclopropyl-1H-1,2,3-triazol- 4-yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 488.2 (M + H+) 
               
               
                   
               
               
                 310  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-(2-(tert-butyl)hydrazinyl)- 8-chloro-6-(((1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 506.2 (M + H+) 
               
               
                   
               
               
                 311  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4- yl)(phenyl)methyl-d)amino)-4- (((R)-1-phenylpropyl) amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 535.1 (M + H+) 
               
               
                   
               
               
                 312  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4- yl)(phenyl)methyl-d)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 487.2 (M + H+) 
               
               
                   
               
               
                 313  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- (((1S,3S)-3- hydroxycyclohexyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 533.2 (M + H+) 
               
               
                   
               
               
                 314  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(((1R,3S)-3- hydroxycyclohexyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 533.2 (M + H+) 
               
               
                   
               
               
                 315  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- (((1S,3R)-3- hydroxycyclohexyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 533.2 (M + H+) 
               
               
                   
               
               
                 316  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(((1R,3R)-3- hydroxycyclohexyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 533.2 (M + H+) 
               
               
                   
               
               
                 317  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- (quinuclidin-3-ylamino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 544.2 (M + H+) 
               
               
                   
               
               
                 318  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(((R)-2,2- dimethylcyclohexyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 545.3 (M + H+) 
               
               
                   
               
               
                 319  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(((S)-2,2- dimethylcyclohexyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 545.3 (M + H+) 
               
               
                   
               
               
                 320  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-((2,6- dimethylcyclohexyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 545.2 (M + H+) 
               
               
                   
               
               
                 321 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-4-((2- methylcyclohexyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 531.2 (M + H+) 
               
               
                   
               
               
                 322  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)- 4-((2-morpholino-1- phenylethyl)amino)quinoline- 3-carbonitrile 
                 2 
                 ES/MS 623.2 (M + H+) 
               
               
                   
               
               
                 323  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)- 4-((2-fluoro-1- phenylethyl)amino)quinoline- 3-carbonitrile 
                 2 
                 ES/MS 556.0 (M + H+) 
               
               
                   
               
               
                 324  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3- cyanophenyl)(1H-1,2,3- triazol-4-yl)methyl-d) amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 472.2 (M + H+) 
               
               
                   
               
               
                 325  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2- cyanophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4-yl) methyl)amino)-4- ((5,6-difluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 554.0 (M + H+) 
               
               
                   
               
               
                 326 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (5-methyl-1H-1,2,3-triazol-4- yl)methyl-d)amino)-4-(((R)-1- phenylpropyl)amino)quinoline- 3-carbonitrile 
                 7 
                 ES/MS 543.1 (M + H+) 
               
               
                   
               
               
                 327  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3- cyanophenyl)(1-(pyridin- 3-yl)-1H-1,2,3-triazo1- 4-yl)methyl-d)amino)- 4-(neopentylamino)quinoline- 3-carbonitrile 
                 3 
                 ES/MS 549.2 (M + H+) 
               
               
                   
               
               
                 328  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2- cyanophenyl)(1H-1,2,3- triazol-4-yl)methyl) amino)-4-((5,6- difluoropyridin-3- yl)amino)quinoline- 3-carbonitrile 
                 15 
                 ES/MS 514.0 (M + H+) 
               
               
                   
               
               
                 329  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(2,6- difluorobenzyl)-1H-1,2,3- triazol-4-yl)(4-fluorophenyl) methyl-d)amino)-4-((5,6- difluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 534.1 (M + H+) 
               
               
                   
               
               
                 330  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((2-(fluoromethyl)- 2H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3- carbonitrile 
                 44 
                 ES/MS 540.1 (M + H+) 
               
               
                   
               
               
                 331  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((R)-2-cyano-1- phenylethyl)amino)-6-(((S)-(1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 564.1 (M + H+) 
               
               
                   
               
               
                 332   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1-(pyridin- 3-yl)-1H- 1,2,3-triazol-4-yl)methyl- d)amino)-4-(((4- methyltetrahydro-2H-pyran- 4-yl)methyl)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 584.2 (M + H+) 
               
               
                   
               
               
                 333  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(((4-methyltetrahydro- 2H-pyran-4-yl)methyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 547.1 (M + H+) 
               
               
                   
               
               
                 334  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((S)-2-cyano-1- phenylethyl)amino)-6-(((S)-(1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 564.3 (M + H+) 
               
               
                   
               
               
                 335  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1-(pyridin- 3-yl)-1H-1,2,3-triazol- 4-yl)methyl-d)amino)- 4-(neopentylamino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 542.1 (M + H+) 
               
               
                   
               
               
                 336  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((4-fluorophenyl)(1-(2- (trifluoromethyl)phenyl)-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 651.1 (M + H+) 
               
               
                   
               
               
                 337  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((4-fluorophenyl) (1-(2-fluorophenyl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 601.1 (M + H+) 
               
               
                   
               
               
                 338  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5-chloro-6- fluoropyridin-3-yl)amino)- 6-(((1-cyclopropyl- 1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 564.0 (M + H+) 
               
               
                   
               
               
                 339  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1-isopropyl-1H- 1,2,3-triazol-4-yl)methyl- d)amino)-4-((5-fluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 532.2 (M + H+) 
               
               
                   
               
               
                 340  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(3- cyanophenyl)(1-cyclopropyl- 1H-1,2,3-triazol- 4-yl)methyl-d)amino)- 4-(((R)-1-phenylpropyl) amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 560.1 (M + H+) 
               
               
                   
               
               
                 341  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3- cyanophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4- yl)methyl-d)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 512.3 (M + H+) 
               
               
                   
               
               
                 342  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-benzyl-1H- 1,2,3-triazol- 4-yl)(4-fluorophenyl)methyl- d)amino)-8-chloro-4-((5,6- difluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 598.1 (M + H+) 
               
               
                   
               
               
                 343  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2- chlorophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4- yl)methyl-d)amino)- 4-(neopentylamino) quinoline-3-carbonitrile 
                 5 
                 ES/MS 521.2 (M + H+) 
               
               
                   
               
               
                 344  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((1-cyclopropyl- 1H-imidazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(neopentylamino) quinoline-3-carbonitrile 
                 7 
                 ES/MS 504.2 (M + H+) 
               
               
                   
               
               
                 345  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)-4- (isobutylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 490.2 (M + H+) 
               
               
                   
               
               
                 346  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)-4- ((thiazol-5- ylmethyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 531.1 (M + H+) 
               
               
                   
               
               
                 347  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)-4- ((3,3,3-trifluoro-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 606.2 (M + H+) 
               
               
                   
               
               
                 348  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)-4- (((tetrahydro-2H-pyran-3- yl)methyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 532.2 (M + H+) 
               
               
                   
               
               
                 349  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)-4- ((2,2-difluoropropyl) amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 512.2 (M + H+) 
               
               
                   
               
               
                 350 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)- 4-((2-methyl-2- phenylpropyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 566.2 (M + H+) 
               
               
                   
               
               
                 351  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-4- ((5,6-difluoropyridin-3- yl)amino)quinoline-3,8- dicarbonitrile 
                 1 
                 ES/MS 539.2 (M + H+) 
               
               
                   
               
               
                 352  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((4-fluorophenyl) (1H-1,2,3-triazol-4- yl)methyl-d)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 508.0 (M + H+) 
               
               
                   
               
               
                 353  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1H-1,2,3- triazol-4- yl)methyl)amino)-4-((5- fluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 489.1 (M + H+) 
               
               
                   
               
               
                 354  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((1-cyclopropyl- 1H-imidazol-4-yl)(4- fluorophenyl)methyl-d) amino)-4-(((R)-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 7 
                 ES/MS 552.1 (M + H+) 
               
               
                   
               
               
                 355  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((1-cyclopropyl-1H- imidazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- ((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 7 
                 ES/MS 546.9 (M + H+) 
               
               
                   
               
               
                 356  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2- chlorophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4-yl) methyl-d)amino)- phenylcyclopropyl)amino quinoline-3-carbonitrile 
                 3 
                 ES/MS 567.2 (M + H+) 
               
               
                   
               
               
                 357  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(2- chlorophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4-yl) methyl-d)amino)- 4-(((R)-1-phenylpropyl)amino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 569.1 (M + H+) 
               
               
                   
               
               
                 358  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2- chlorophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4-yl) methyl-d)amino)- 4-((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 4 
                 ES/MS 564.1 (M + H+) 
               
               
                   
               
               
                 359  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((1-(1,1-dioxidothietan-3-yl)- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 4 
                 ES/MS 612.1 (M + H+) 
               
               
                   
               
               
                 360  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((5,6- difluoropyridin-3- yl)amino)-6-(((S)-(4- fluorophenyl)(1-((S)-1- fluoropropan-2-yl)-1H-1,2,3- triazol-4-yl)methyl- d)amino)quinoline-3-carbonitrile 
                 4 
                 ES/MS 568.1 (M + H+) 
               
               
                   
               
               
                 361  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(2,2- difluoroethyl)-1H-1,2,3- triazol-4- yl)(4-fluorophenyl)methyl- d)amino)-4-((5,6- difluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 4 
                 ES/MS 572.1 (M + H+) 
               
               
                   
               
               
                 362  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((2-cyano-1- phenylethyl)amino)-6-(((S)-(4- fluorophenyl)(1-isopropyl-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 565.2 (M + H+) 
               
               
                   
               
               
                 363  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1-isopropyl-1H- 1,2,3-triazol-4-yl)methyl) amino)-4-(((R)-2,2,2-trifluoro-1- phenylethyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 594.2 (M + H+) 
               
               
                   
               
               
                 364  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1-isopropyl-1H- 1,2,3-triazol-4-yl)methyl) amino)-4-(((S)-2,2,2-trifluoro-1- phenylethyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 594.2 (M + H+) 
               
               
                   
               
               
                 365  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1-isopropyl-1H- 1,2,3-triazol-4-yl)methyl) amino)-4-(((R)-1-(p- tolyl)propyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 568.2 (M + H+) 
               
               
                   
               
               
                 366  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1-isopropyl-1H- 1,2,3-triazol-4-yl)methyl) amino)-4-(((R)-1-(o- tolyl)propyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 568.2 (M + H+) 
               
               
                   
               
               
                 367  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((2,4- difluorophenyl)amino)-6-(((4- fluorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 506.1 (M + H+) 
               
               
                   
               
               
                 368  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3,4- difluorophenyl)amino)-6-(((4- fluorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 506.1 (M + H+) 
               
               
                   
               
               
                 369  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3- cyanophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)methyl- d)amino)- 4-((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 555.1 (M + H+) 
               
               
                   
               
               
                 370  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3- cyanophenyl)(1H-1,2,3-triazol-4- yl)methyl-d)amino)-4-((5,6- difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 15 
                 ES/MS 515.1 (M + H+) 
               
               
                   
               
               
                 371  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((4-fluorophenyl)(1-(1- (trifluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4-yl)methyl- d)amino)quinoline-3-carbonitrile 
                 4 
                 ES/MS 616.1 (M + H+) 
               
               
                   
               
               
                 372  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3-cyano-4- fluorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)-4-((5,6- difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 15 
                 ES/MS 532.1 (M + H+) 
               
               
                   
               
               
                 373  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1H-1,2,3-triazol- 4-yl)methyl)amino)-4-((2- fluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 15 
                 ES/MS 489.1 (M + H+) 
               
               
                   
               
               
                 374  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1H-1,2,3-triazol- 4-yl)methyl)amino)-4-((6- fluoropyridin-3-yl) amino)quinoline-3-carbonitrile 
                 15 
                 ES/MS 490.1 (M + H+) 
               
               
                   
               
               
                 375  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((6-fluoro-5- methylpyridin-3-yl)amino)-6- (((4-fluorophenyl)(1H-1,2,3- triazol-4-yl)methyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 503.1 (M + H+) 
               
               
                   
               
               
                 376  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2- chlorophenyl)(1H-1,2,3-triazol- 4-yl)methyl)amino)-4-((5,6- difluoropyridin-3-yl) amino)quinoline-3-carbonitrile 
                 15 
                 ES/MS 523.1 (M + H+) 
               
               
                   
               
               
                 377  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1- (difluoromethyl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino)- 4-((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 44 
                 ES/MS 557.1 (M + H+) 
               
               
                   
               
               
                 378  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2- (difluoromethyl)-2H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino)-4- ((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 44 
                 ES/MS 557.1 (M + H+) 
               
               
                   
               
               
                 379 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1-(1- (trifluoromethyl)cyclopropyl)- 1H-1,2,3-triazo1-4-yl)methyl) amino)-4-(((R)-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 620.2 (M + H+) 
               
               
                   
               
               
                 380  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((4-fluorophenyl) (1-(tetrahydro-2H- pyran-4-yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 591.1 (M + H+) 
               
               
                   
               
               
                 381  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(tert-butyl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-8- chloro-4-((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 564.0 (M + H+) 
               
               
                   
               
               
                 382  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- ((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 4 
                 ES/MS 548.0 (M + H+) 
               
               
                   
               
               
                 383  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-(((8-chloro-4-((3-chloro-4- fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(1- isopropyl-1H-1,2,3-triazol-4- yl)methyl)-N,N- dimethylbenzenesulfonamide 
                 3 
                 ES/MS 653.3 (M + H+) 
               
               
                   
               
               
                 384  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)-6- (((4-fluorophenyl)(1-((1- hydroxycyclopropyl) methyl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 4 
                 ES/MS 577.0 (M + H+) 
               
               
                   
               
               
                 385  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((1-isopropyl-1H- 1,2,3-triazol-4-yl)(3- (1-methyl-1H-imidazol-2- yl)phenyl)methyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 611.0 (M + H+) 
               
               
                   
               
               
                 386  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl) amino)-6-(((3- (1-methyl-1H-imidazol-2- yl)phenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 569.0 (M + H+) 
               
               
                   
               
               
                 387  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- chlorophenyl)(1H-1,2,3- triazol-4-yl)methyl-d)amino)- 4-((5,6-difluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 524.0 (M + H+) 
               
               
                   
               
               
                 388  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((4-fluorophenyl)(1-(pyridin- 4-yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 584.1 (M + H+) 
               
               
                   
               
               
                 389  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((4-fluorophenyl) (1-(pyridin-3-yl)-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 584.1 (M + H+) 
               
               
                   
               
               
                 390  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1-(pyridin-4- yl)-1H-1,2,3-triazol-4-yl) methyl)amino)-4-(((R)-1- phenylpropyl)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 589.2 (M + H+) 
               
               
                   
               
               
                 391  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1-(pyridin-3- yl)-1H-1,2,3-triazol- 4-yl)methyl)amino)-4- (((R)-1-phenylpropyl) amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 589.2 (M + H+) 
               
               
                   
               
               
                 392  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1-phenyl- 1H-1,2,3- triazol-4-yl)methyl)amino)- 4-(((R)-1-phenylpropyl) amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 588.2 (M + H+) 
               
               
                   
               
               
                 393  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1-(pyridin- 4-yl)-1H-1,2,3-triazol- 4-yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 541.2 (M + H+) 
               
               
                   
               
               
                 394  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1-(pyridin-3- yl)-1H-1,2,3-triazol- 4-yl)methyl)amino)-4- (neopentylamino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 541.2 (M + H+) 
               
               
                   
               
               
                 395  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1-phenyl-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 540.2 (M + H+) 
               
               
                   
               
               
                 396  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-((o-tolyl(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 503.0 (M + H+) 
               
               
                   
               
               
                 397  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)-4-((1-(2- fluorophenyl)propyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 530.1 (M + H+) 
               
               
                   
               
               
                 398  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1H-1,2,3-triazol- 4-yl)methyl)amino)-4-(((4- methyltetrahydro-2H-pyran-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 506.2 (M + H+) 
               
               
                   
               
               
                 399  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1H-1,2,3- triazol-4-yl)methyl) amino)-4-((2,2,3- trimethylbutyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 492.2 (M + H+) 
               
               
                   
               
               
                 400  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1H-1,2,3- triazol-4-yl)methyl) amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 464.2 (M + H+) 
               
               
                   
               
               
                 401  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1H-1,2,3- triazol-4-yl)methyl) amino)-4-((thiazol-4- ylmethyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 491.1 (M + H+) 
               
               
                   
               
               
                 402  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1H-1,2,3- triazol-4-yl)methyl) amino)-4-((thiazol-2- ylmethyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 491.1 (M + H+) 
               
               
                   
               
               
                 403  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((4-fluorophenyl) (1-(3-methyloxetan-3- yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 4 
                 ES/MS 577.1 (M + H+) 
               
               
                   
               
               
                 404  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2- (difluoromethyl)phenyl) (1H-1,2,3-triazol-4-yl) methyl)amino)-4-((5,6- difluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 539.0 (M + H+) 
               
               
                   
               
               
                 405  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((1-((3-fluorooxetan- 3-yl)methyl)-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 595.1 (M + H+) 
               
               
                   
               
               
                 406  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((5,6-difluoropyridin- 3-yl)amino)-6-(((S)-(4- fluorophenyl)(1-((R)-1,1,1- trifluoropropan-2-yl)-1H-1,2,3- triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 4 
                 ES/MS 603.1 (M + H+) 
               
               
                   
               
               
                 407  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((1S)-(1-(1,1- difluoropropan-2-yl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino)-4- ((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 4 
                 ES/MS 585.1 (M + H+) 
               
               
                   
               
               
                 408  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((4-fluorophenyl) (1-phenyl-1H-1,2,3- triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 583.0 (M + H+) 
               
               
                   
               
               
                 409  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(2,2- difluoroethyl)-1H-1,2,3- triazol-4-yl)(4-fluorophenyl) methyl)amino)- 4-((5,6-difluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 4 
                 ES/MS 571.1 (M + H+) 
               
               
                   
               
               
                 410  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1- (cyanomethyl)- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)-4- ((5,6-difluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 546.1 (M + H+) 
               
               
                   
               
               
                 411  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((4-fluorophenyl)(1- neopentyl-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 577.2 (M + H+) 
               
               
                   
               
               
                 412  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((4-fluorophenyl)(1-((1- methylcyclopropyl)methyl)-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 575.2 (M + H+) 
               
               
                   
               
               
                 413  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((4-fluorophenyl)(1-((1- methylcyclobutypmethyl)-1H- 1,2,3-triazol-4- yl)methyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 589.2 (M + H+) 
               
               
                   
               
               
                 414  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5-chloro-6- fluoropyridin-3-yl)amino)-6- (((1-cyclopropyl-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 563.1 (M + H+) 
               
               
                   
               
               
                 415  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1H-1,2,3-triazol-4- yl)methyl-d)amino)-4-(((R)-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 513.1 (M + H+) 
               
               
                   
               
               
                 416  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1-methyl- 1H-1,2,3-triazol-4-yl) methyl)amino)-4-(((R)- 1-phenylpropyl)amino) quinoline-3-carbonitrile 
                 45 
                 ES/MS 526.2 (M + H+) 
               
               
                   
               
               
                 417 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl) amino)-6-(((4- fluorophenyl)(1-(1- (trifluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 615.1 (M + H+) 
               
               
                   
               
               
                 418  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1H-1,2,3- triazol-4-yl)methyl) amino)-4-((thiophen-2- ylmethyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 490.1 (M + H+) 
               
               
                   
               
               
                 419  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1H-1,2,3- triazol-4-yl)methyl) amino)-4-((thiophen-3- ylmethyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 490.1 (M + H+) 
               
               
                   
               
               
                 420  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1H-1,2,3- triazol-4- yl)methyl)amino)-4- (((tetrahydrofuran-3- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 478.1 (M + H+) 
               
               
                   
               
               
                 421  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)-4-((oxetan-3- ylmethyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 464.1 (M + H+) 
               
               
                   
               
               
                 422  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-chloro-4- fluorophenyl)(1H-1,2,3- triazol-4- yl)methyl)amino)-4-((5,6- difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 15 
                 ES/MS 541.1 (M + H+) 
               
               
                   
               
               
                 423  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- cyanophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)-4-((5,6- difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 15 
                 ES/MS 514.1 (M + H+) 
               
               
                   
               
               
                 424  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3- cyanophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)-4-((5,6- difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 15 
                 ES/MS 514.1 (M + H+) 
               
               
                   
               
               
                 425  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5-chloro-6- fluoropyridin-3-yl)amino)-6-(((4- fluorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 523.0 (M + H+) 
               
               
                   
               
               
                 426  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(2- (difluoromethyl)-2H-1,2,3- triazol-4-yl)(2,3- difluorophenyl)methyl) amino)-4-(((R)-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 44 
                 ES/MS 580.1 (M + H+) 
               
               
                   
               
               
                 427  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1- (difluoromethyl)-1H-1,2,3- triazol-5-yl)(2,3- difluorophenyl)methyl) amino)-4-(((R)-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 44 
                 ES/MS 580.1 (M + H+) 
               
               
                   
               
               
                 428  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1- (difluoromethyl)-1H-1,2,3- triazol-4-yl)(2,3- difluorophenyl)methyl) amino)-4-(((R)-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 44 
                 ES/MS 580.1 (M + H+) 
               
               
                   
               
               
                 429  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(2- fluorophenyl)methyl)amino)-4- (((R)-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 552.1 (M + H+) 
               
               
                   
               
               
                 430  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(2- fluorophenyl)methyl)amino)-4- ((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 547.2 (M + H+) 
               
               
                   
               
               
                 431  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((2-fluorophenyl)(1- ((trimethylsilyl)methyl)-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 593.1 (M + H+) 
               
               
                   
               
               
                 432  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)-4-(((S)-3- hydroxy-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 528.1 (M + H+) 
               
               
                   
               
               
                 433  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)-4-(((S)-2- hydroxy-1-phenylethyl) amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 514.0 (M + H+) 
               
               
                   
               
               
                 434  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((4-fluorophenyl)(5- methoxy-1H-1,2,3-triazol-4- yl)methyl)amino)-4-(((R)-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 7 
                 ES/MS 542.1 (M + H+) 
               
               
                   
               
               
                 435  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((5,6- difluoropyridin-3- yl)amino)-6-(((4- fluorophenyl)(5-methoxy- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 7 
                 ES/MS 537.1 (M + H+) 
               
               
                   
               
               
                 436  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1H-1,2,3- triazol-4-yl)methyl) amino)-4-(((tetrahydro- 2H-pyran-2-yl)methyl) amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 492.2 (M + H+) 
               
               
                   
               
               
                 437  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl) piperidin-4-yl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino)- 8-chloro-4-(((tetrahydro- 2H-pyran-2-yl)methyl) amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 631.3 (M + H+) 
               
               
                   
               
               
                 438  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1H-1,2,3- triazol-4- yl)methyl)amino)-4-((3- hydroxycyclohexyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 492.1 (M + H+) 
               
               
                   
               
               
                 439  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1H-1,2,3- triazol-4- yl)methyl)amino)-4-((3- hydroxycyclohexyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 492.1 (M + H+) 
               
               
                   
               
               
                 440  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)-8- chloro-4-((3- hydroxycyclohexyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 631.3 (M + H+) 
               
               
                   
               
               
                 441  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)-8- chloro-4-((3- hydroxycyclohexyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 631.3 (M + H+) 
               
               
                   
               
               
                 442  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)-8- chloro-4-((2- methoxybenzyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 653.3 (M + H+) 
               
               
                   
               
               
                 443  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1H-1,2,3- triazol-4-yl)methyl) amino)-4-((2,2,2- trifluoroethyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 476.1 (M + H+) 
               
               
                   
               
               
                 444  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(2- fluorophenyl)(1H-1,2,3- triazol-4-yl)methyl) amino)-4-(((R)-1 phenylpropyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 512.2 (M + H+) 
               
               
                   
               
               
                 445  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(2,3- difluorophenyl)(1H-1,2,3- triazol-4-yl)methyl)amino)-4- (((R)-1-phenylpropyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 530.1 (M + H+) 
               
               
                   
               
               
                 446  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-(2- fluoroethyl)- 1H-1,2,3-triazol-4-yl)(2- fluorophenyl)methyl) amino)-4-(((R)-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 558.2 (M + H+) 
               
               
                   
               
               
                 447  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((2-fluorophenyl) (1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 507.1 (M + H+) 
               
               
                   
               
               
                 448  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2,3- difluorophenyl)(1H-1,2,3- triazol-4-yl)methyl) amino)-4-((5,6- difluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 525.1 (M + H+) 
               
               
                   
               
               
                 449  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3,4-dichloro-2- fluorophenyl)amino)-6-(((4- fluorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 556.0 (M + H+) 
               
               
                   
               
               
                 450  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(3- (oxazol-2-yl)phenyl) methyl)amino)-4-((5,6- difluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 595.9 (M + H+) 
               
               
                   
               
               
                 451  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin-4-yl)-1H-1,2,3- triazol-4-yl)(phenyl) methyl)amino)-8- chloro-4-42-methoxy-2- methylpropyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 601.3 (M + H+) 
               
               
                   
               
               
                 452  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((3-methyloxetan-3- yl)methyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 599.3 (M + H+) 
               
               
                   
               
               
                 453  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)- 8-chloro-4-(((1- methylcyclobutyl)methyl) amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 597.3 (M + H+) 
               
               
                   
               
               
                 454  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4- ((cyclobutylmethyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 538.3 (M + H+) 
               
               
                   
               
               
                 455  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((1- methylcyclopropyl)methyl) amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 583.3 (M + H+) 
               
               
                   
               
               
                 456  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)-4- ((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 547.1 (M + H+) 
               
               
                   
               
               
                 457  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(tert-butyl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino)-8- chloro-4-((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 563.1 (M + H+) 
               
               
                   
               
               
                 458  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((4-fluorophenyl)(1- isopropyl-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 549.1 (M + H+) 
               
               
                   
               
               
                 459  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl) amino)-6-(((4- fluorophenyl)(1-(3-pyrrolidin-1- yl)propyl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 618.2 (M + H+) 
               
               
                   
               
               
                 460  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2,4- difluorophenyl)(1H-1,2,3- triazol-4- yl)methyl)amino)-4-((5,6- difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 15 
                 ES/MS 525.1 (M + H+) 
               
               
                   
               
               
                 461  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)-6- ((phenyl(1H-1,2,3-triazol-4- yl)methyl-d)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 490.0 (M + H+) 
               
               
                   
               
               
                 462  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3,4-dichloro-2- fluorophenyl)amino)-6-(((3- (methylsulfonyl)phenyl) (1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 615.9 (M + H+) 
               
               
                   
               
               
                 463  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3,4-dichloro-2- fluorophenyl)amino)-6- ((phenyl(1H-1,2,3-triazol-4- yl)methyl-d)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 539.0 (M + H+) 
               
               
                   
               
               
                 464  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- cyanophenyl)(1H-1,2,3- triazol-4- yl)methyl)amino)-4-((3,4- dichloro- 2-fluorophenyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 562.9 (M + H+) 
               
               
                   
               
               
                 465  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3- cyanophenyl)(1H-1,2,3- triazol-4- yl)methyl)amino)-4-((3,4- dichloro- 2-fluorophenyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 562.9 (M + H+) 
               
               
                   
               
               
                 466  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3- cyanophenyl)(1-(oxetan- 3-yl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- ((3,4-dichloro-2- fluorophenyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 619.0 (M + H+) 
               
               
                   
               
               
                 467    
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2,4- difluorophenyl)(1-(oxetan- 3-yl)-1H-1,2,3-triazol-4- yl)methyl)amino)-4-((5,6- difluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 581.0 (M + H+) 
               
               
                   
               
               
                 468  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(tert-butyl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((6-methoxypyridin-3- yl)amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 539.1 (M + H+) 
               
               
                   
               
               
                 469  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-cyano-2,4- difluorophenyl)amino)-6- ((phenyl(1-(3-(pyrrolidin-1- yl)propyl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 624.2 (M + H+) 
               
               
                   
               
               
                 470  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((3-cyano-2,4- difluorophenyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 652.2 (M + H+) 
               
               
                   
               
               
                 471  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((2-cyano-4- fluorophenyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 634.2 (M + H+) 
               
               
                   
               
               
                 472  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-((phenyl(1-(3- (pyrrolidin-1-yl)propyl)- 1H-1,2,3- triazol-4-yl)methyl)amino)-4- ((2,4,6- trifluorophenyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 617.2 (M + H+) 
               
               
                   
               
               
                 473  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((2,4,6- trifluorophenyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 645.2 (M + H+) 
               
               
                   
               
               
                 474  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4 yl)(phenyl)methyl)amino)-8- chloro-4-((3,3- dimethylbutyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 599.3 (M + H+) 
               
               
                   
               
               
                 475  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((1-methyl-1H- pyrazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 609.3 (M + H+) 
               
               
                   
               
               
                 476  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((1-methyl-1H- pyrazol-3- yl)methyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 609.3 (M + H+) 
               
               
                   
               
               
                 477  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((1-methyl-1H- pyrazol-5- yl)methyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 609.3 (M + H+) 
               
               
                   
               
               
                 478  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((1-methyl-1H- pyrazol-4- yl)amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 595.3 (M + H+) 
               
               
                   
               
               
                 479  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((2-oxo-2,3- dihydro-1H-benzo[d]imidazol- 4-yl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 647.3 (M + H+) 
               
               
                   
               
               
                 480  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((2-methoxypyridin-3- yl)amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 622.3 (M + H+) 
               
               
                   
               
               
                 481  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(ethyl((S)- phenyl(1H- 1,2,3-triazol-4-yl) methyl)amino)-4-(((R)-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 522.2 (M + H+) 
               
               
                   
               
               
                 482  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((1-methyl- 6-oxo-1,6-dihydropyridin- 3-yl)amino)-6-((phenyl (1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 483.1 (M + H+) 
               
               
                   
               
               
                 483  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((1-methyl- 6-oxo- 1,6-dihydropyridin-3-yl) amino)-6-(((1-(oxetan-3- yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 3  
                 ES/MS 539.0 (M + H+) 
               
               
                   
               
               
                 484  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((1-methyl-6-oxo- 1,6-dihydropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 622.0 (M + H+) 
               
               
                   
               
               
                 485  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((R)-3,3- dimethylbutan-2-yl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 599.3 (M + H+) 
               
               
                   
               
               
                 486  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((S)-3,3- dimethylbutan-2- yl)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 599.3 (M + H+) 
               
               
                   
               
               
                 487 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)- 8-chloro-4-(((R)-1,2,3,4- tetrahydronaphthalen-1- yl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 645.3 (M + H+) 
               
               
                   
               
               
                 488  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)- 8-chloro-4-(((S)-1,2,3,4- tetrahydronaphthalen-1- yl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 645.3 (M + H+) 
               
               
                   
               
               
                 489  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)- 8-chloro-4- (((trimethylsilyl)methyl) amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 601.3 (M + H+) 
               
               
                   
               
               
                 490  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((6- methoxypyridin- 3-yl)amino)-6-((phenyl (1H-1,2,3-triazol-4- yl)methyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 483.0 (M + H+) 
               
               
                   
               
               
                 491  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((6- methoxypyridin- 3-yl)amino)-6-(((1- (oxetan-3-yl)- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 539.0 (M + H+) 
               
               
                   
               
               
                 492  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino)- 8-chloro-4-((6- methoxypyridin-3- yl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 622.0 (M + H+) 
               
               
                   
               
               
                 493  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((1-(2-fluoroethyl)- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 553.1 (M + H+) 
               
               
                   
               
               
                 494  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- chlorophenyl)(1-(oxetan- 3-yl)-1H-1,2,3-triazol- 4-yl)methyl)amino)-4- ((5,6-difluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 578.9 (M + H+) 
               
               
                   
               
               
                 495  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- chlorophenyl)(1H-1,2,3- triazol-4-yl)methyl) amino)-4-((5,6- difluoropyridin-3-yl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 523.1 (M + H+) 
               
               
                   
               
               
                 496  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(3-(((8-chloro-3- cyano-4- ((5,6-difluoropyridin-3- yl)amino)quinolin-6-yl) amino)(1H-1,2,3-triazol- 4-yl)methyl)phenyl)- N-methylacetamide 
                 15 
                 ES/MS 559.9 (M + H+) 
               
               
                   
               
               
                 497  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6- (((S)-(1-((3R,4R)- 3-hydroxy-1-(oxetan-3- yl)piperidin-4-yl)-1H-1,2,3- triazol-yl)(phenyl)methyl) amino)quinoline- 3-carbonitrile 
                 5 
                 ES/MS 659.0 (M + H+) 
               
               
                   
               
               
                 498  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((3-(oxazol-2-yl) phenyl)(1H-1,2,3- triazol-4-yl)methyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 555.9 (M + H+) 
               
               
                   
               
               
                 499  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl) amino)-6-(((3- (oxazol-2-yl)phenyl) (1-(oxetan-3- yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 611.9 (M + H+) 
               
               
                   
               
               
                 500  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl) amino)-6-(((1- (oxetan-3-yl)-1H-1,2,3- triazol-4-yl)(2,4,6- trifluorophenyl)methyl) amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 599.0 (M + H+) 
               
               
                   
               
               
                 501  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((1-(oxetan-3-yl)- 1H-1,2,3-triazol-4-yl)(2- (trifluoromethyl)phenyl)methyl) amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 613.0 (M + H+) 
               
               
                   
               
               
                 502  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1H-1,2,3-triazol- 4-yl)(2-(trifluoromethyl) phenyl)methyl) amino)-8-chloro-4-((5,6- difluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 557.0 (M + H+) 
               
               
                   
               
               
                 503  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1H-1,2,3-triazol-4- yl)(2,4,6- trifluorophenyl)methyl) amino)-8-chloro-4- ((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 15 
                 ES/MS 543.0 (M + H+) 
               
               
                   
               
               
                 504  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-amino-6-(((1-(1-(tert- butyl)piperidin-4-yl)-1H-1,2,3- triazol-4- yl)(phenyl)methyl)amino)-8- chloroquinoline-3-carbonitrile 
                 1 
                 ES/MS 515.2 (M + H+) 
               
               
                   
               
               
                 505  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((4-fluoro-3- (trifluoromethyl)phenyl) amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 677.2 (M + H+) 
               
               
                   
               
               
                 506  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)- 8-chloro-4-(((R)-chroman-4- yl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 647.3 (M + H+) 
               
               
                   
               
               
                 507  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((S)-chroman-4- yl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 647.3 (M + H+) 
               
               
                   
               
               
                 508  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((1-(tetrahydro- 2H-pyran-4-yl)propyl) amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 641.3 (M + H+) 
               
               
                   
               
               
                 509  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)- 8-chloro-4-((2,6- dimethyltetrahydro- 2H-pyran-4-yl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 627.3 (M + H+) 
               
               
                   
               
               
                 510  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(3-(((8-chloro-3- cyano-4- ((5,6-difluoropyridin-3- yl)amino)quinolin-6-yl) amino)(1-(2,2,2- trifluoroethyl)-1H-1,2,3- triazol-4-yl)methyl)phenyl)- N-methylacetamide 
                 3 
                 ES/MS 641.9 (M + H+) 
               
               
                   
               
               
                 511  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl) amino)-6-(((4- fluorophenyl)(1-(oxetan-3- yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 562.9 (M + H+) 
               
               
                   
               
               
                 512  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)- 6-(((4-fluorophenyl)(1-(2,2,2- trifluoroethyl)-1H-1,2,3- triazol-4-yl)methyl) amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 588.9 (M + H+) 
               
               
                   
               
               
                 513  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl) amino)-6-(((4- fluorophenyl)(1H-1,2,3- triazol-4-yl)methyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 507.0 (M + H+) 
               
               
                   
               
               
                 514  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6- (((S)-(1-((3R,4R)-1-ethyl- 3-hydroxypiperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 5 
                 ES/MS 631.0 (M + H+) 
               
               
                   
               
               
                 515  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6- (((S)-(1-((3R,4R)-3- hydroxypiperidin-4-yl)- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 5 
                 ES/MS 603.1 (M + H+) 
               
               
                   
               
               
                 516  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3- chlorophenyl)amino)-6- ((S)-(1-((3R,4R)-1-ethyl- 3-hydroxypiperidin-4-yl)- 1H-1,2,3-triazol-4-yl)(phenyl) methyl)amino)quinoline- 3-carbonitrile 
                 5 
                 ES/MS 613.1 (M + H+) 
               
               
                   
               
               
                 517  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3- chlorophenyl)amino)-6- (((S)-(1-((3R,4R)-3- hydroxy-1-(oxetan-3- yl)piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 5 
                 ES/MS 641.2 (M + H+) 
               
               
                   
               
               
                 518  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3,4- dichloro-2- fluorophenyl)amino)- 6-(((3-((3,3- difluoroazetidin-1- yl)methyl)phenyl)(1H- 1,2,3-triazol- 4-yl)methyl)amino) quinoline-3-carbonitrile 
                 18 
                 ES/MS 643.1 (M + H+) 
               
               
                   
               
               
                 519  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6- (((5-(morpholinomethyl)- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 7 
                 ES/MS 603.0 (M + H+) 
               
               
                   
               
               
                 520  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(6-(((1-(1-(tert- butyl)piperidin-4-yl)- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-3-cyanoquinolin-4- yl)benzenesulfonamide 
                 16 
                 ES/MS 655.2 (M + H+) 
               
               
                   
               
               
                 521  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino)- 8-chloro-4-((6-chloro-5- fluoropyridin-3- yl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 644.2 (M + H+) 
               
               
                   
               
               
                 522  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl) piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((S)-1-(tetrahydro- 2H-pyran-4-yl)ethyl) amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 627.3 (M + H+) 
               
               
                   
               
               
                 523  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl) piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino)- 8-chloro-4-(((R)-1- cyclohexylethyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 625.3 (M + H+) 
               
               
                   
               
               
                 524  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl) piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino)- 8-chloro-4-(((R)-1- (tetrahydro-2H- pyran-4-yl)ethyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 627.3 (M + H+) 
               
               
                   
               
               
                 525  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino)- 8-chloro-4-((4-fluoro-3- (trifluoromethoxy)phenyl) amino)quinoline-3-carbonitrile 
                 15 
                 ES/MS 693.2 (M + H+) 
               
               
                   
               
               
                 526  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)- 8-chloro-4-((2,3- dichlorophenyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 659.2 (M + H+) 
               
               
                   
               
               
                 527  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino)- 8-chloro-4-((2,5- dichlorophenyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 661.2 (M + H+) 
               
               
                   
               
               
                 528  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3,4-dichloro- 2-fluorophenyl)amino)-6-(((3- (1,1-dioxidoisothiazolidin-2- yl)phenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 657.0 (M + H+) 
               
               
                   
               
               
                 529  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-((1R,5S,6s)-3- azabicyclo[3.1.0]hexan- 6-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 585.1 (M + H+) 
               
               
                   
               
               
                 530  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-2-(4-(((8-chloro-3-cyano- 4-((3,4-dichloro-2- fluorophenyl)amino)quinolin- 6-yl)amino)(phenyl)methyl)- 1H-1,2,3-triazol-1-yl)-N,N- diethyl-N-methylethan-1- aminium 
                 1 
                   
               
               
                   
               
               
                 531  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3,4-dichloro-2- fluorophenyl)amino)-6-(((3-(2- oxopyrrolidin-1-yl)phenyl)(1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 620.9 (M + H+) 
               
               
                   
               
               
                 532  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((R)-(2- chlorophenyl)(1H-1,2,3- triazol-4-yl)methyl)amino)- 4-(((R)-1-phenylpropyl) amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 528.2 (M + H+) 
               
               
                   
               
               
                 533  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(2- chlorophenyl)(1H-1,2,3- triazol-4-yl)methyl) amino)-4-(((R)-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 528.1 (M + H+) 
               
               
                   
               
               
                 534  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopentyl- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)- 4-((3,4-dichloro-2- fluorophenyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 606.1 (M + H+) 
               
               
                   
               
               
                 535 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3- chlorophenyl)amino)- 6-(((S)-(1-((3R,4R)-3- hydroxypiperidin-4-yl)- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 5 
                 ES/MS 585.1 (M + H+) 
               
               
                   
               
               
                 536  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-phenyl (1-(3-(pyrrolidin-1-yl) propyl)-1H-1,2,3- triazol-4-yl)methyl)amino)- 4-(((R)-1-phenylpropyl) amino)quinoline-3- carbonitrile 
                 2 
                 ES/MS 605.2 (M + H+) 
               
               
                   
               
               
                 537  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- fluorophenyl)(1H-1,2,3- triazol-4-yl)methyl) amino)-4-(((R)-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 512.2 (M + H+) 
               
               
                   
               
               
                 538  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl) piperidin-4-yl)-1H-1,2,3- triazol-4-yl)(4-fluorophenyl) methyl)amino)-8- chloro-4-(((R)-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 651.3 (M + H+) 
               
               
                   
               
               
                 539  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl) piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((S)-tetrahydro-2H- pyran-3-yl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 599.3 (M + H+) 
               
               
                   
               
               
                 540  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl) piperidin-4-yl)-1H-1,2,3- triazol-4-yl)(phenyl) methyl)amino)-8-chloro- 4-(((R)-tetrahydro-2H- pyran-3-yl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 599.3 (M + H+) 
               
               
                   
               
               
                 541  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-isopropyl- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-4- ((1-methylpiperidin-4- yl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 515.2 (M + H+) 
               
               
                   
               
               
                 542  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3- (dimethylamino)propyl) amino)-6-(((1-isopropyl- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 503.2 (M + H+) 
               
               
                   
               
               
                 543  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin-4-yl)-1H-1,2,3- triazol-4-yl)(phenyl) methyl)amino)-8-chloro-4- (neopentylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 585.3 (M + H+) 
               
               
                   
               
               
                 544  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6- ((phenyl(1- (3-(pyrrolidin-1-yl)oxetan-3- yl)methyl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 4 
                 ES/MS 643.1 (M + H+) 
               
               
                   
               
               
                 545  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-((phenyl (1-(3-(pyrrolidin-1-yl)propyl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 4 
                 ES/MS 615.1 (M + H+) 
               
               
                   
               
               
                 546  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-((phenyl (1-(2-(pyrrolidin-1-yl)ethyl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 4 
                 ES/MS 601.1 (M + H+) 
               
               
                   
               
               
                 547  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1- isopropyl-1H-1,2,3-triazol-4-yl) (3-(2-oxopiperidin-1- yl)phenyl)methyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 642.9 (M + H+) 
               
               
                   
               
               
                 548  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3-(2- oxopiperidin-1- yl)phenyl)methyl)amino)-8-chloro- 4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 740.0 (M + H+) 
               
               
                   
               
               
                 549  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1- isopropyl-1H-1,2,3-triazol-4-yl) (3-(2-oxopyrrolidin-1- yl)phenyl)methyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 629.0 (M + H+) 
               
               
                   
               
               
                 550  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3-(2- oxopyrrolidin-1- yl)phenyl)methyl)amino)-8-chloro- 4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 726.0 (M + H+) 
               
               
                   
               
               
                 551  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1- isopropyl-1H-1,2,3-triazol-4-yl)(3- (2-oxoazetidin-1- yl)phenyl)methyl)amino)quinoline- 3-carbonitrile 
                 3 
                 ES/MS 615.0 (M + H+) 
               
               
                   
               
               
                 552  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3-(2- oxoazetidin-1- yl)phenyl)methyl)amino)-8-chloro- 4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 712.0 (M + H+) 
               
               
                   
               
               
                 553  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((R)-2-methyl-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 647.3 (M + H+) 
               
               
                   
               
               
                 554  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((2- methoxyethyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 573.3 (M + H+) 
               
               
                   
               
               
                 555  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((2-hydroxy-2- methylpropyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 587.3 (M + H+) 
               
               
                   
               
               
                 556  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((R)-1-methoxypropan- 2-yl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 587.3 (M + H+) 
               
               
                   
               
               
                 557  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((S)-1-methoxypropan-2- yl)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 587.3 (M + H+) 
               
               
                   
               
               
                 558  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((R)-1- phenylbutyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 647.3 (M + H+) 
               
               
                   
               
               
                 559  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(3-(3- methoxyazetidine-1- carbonyl)phenyl)(1H-1,2,3-triazol- 4-yl)methyl)amino)-4-(((R)-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 20 
                 ES/MS 607.0 (M + H+) 
               
               
                   
               
               
                 560  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(3-(3- hydroxyazetidine-1- carbonyl)phenyl)(1H-1,2,3-triazol- 4-yl)methyl)amino)-4-4(R)-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 20 
                 ES/MS 593.0 (M + H+) 
               
               
                   
               
               
                 561  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(3-(3,3- difluoroazetidine-1- carbonyl)phenyl)(1H-1,2,3-triazol- 4-yl)methyl)amino)-4-(((R)-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 20 
                 ES/MS 613.0 (M + H+) 
               
               
                   
               
               
                 562    
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(3-(3- fluoroazetidine-1- carbonyl)phenyl)(1H-1,2,3-triazol- 4-yl)methyl)amino)-4-(((R)-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 20 
                 ES/MS 595.0 (M + H+) 
               
               
                   
               
               
                 563  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N-(3-((S)-((8-chloro-3-cyano-4- (((R)-1- phenylpropyl)amino)quinolin-6- yl)amino)(1H-1,2,3-triazol-4- yl)methyl)phenyl)-N- methylacetamide 
                 15 
                 ES/MS 565.1 (M + H+) 
               
               
                   
               
               
                 564  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 N-(3-((S)-(1-(1-(tert- butyl)piperidin-4-yl)-1H-1,2,3- triazol-4-yl)((8-chloro-3-cyano-4 (((R)-1- phenylpropyl)amino)quinolin-6- yl)amino)methyl)phenyl)-N- methylacetamide 
                 3 
                 ES/MS 704.2 (M + H+) 
               
               
                   
               
               
                 565  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-((S)-((8-chloro-3-cyano-4-(((R)- 1-phenylpropyl)amino)quinolin-6- yl)amino)(1H-1,2,3-triazol-4- yl)methyl)benzoic acid 
                 19 
                 ES/MS 538.0 (M + H+) 
               
               
                   
               
               
                 566  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(3-(((8-chloro-4-((3-chloro- 4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(1- isopropyl-1H-1,2,3-triazol-4- yl)methyl)phenyl) methanesulfonamide 
                 25 
                 ES/MS 639.0 (M + H+) 
               
               
                   
               
               
                 567  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(3-(((8-chloro-4-((3-chloro- 4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(1- isopropyl-1H-1,2,3-triazol-4- yl)methyl)phenyl)-N- methylmethanesulfonamide 
                 3 
                 ES/MS 653.0 (M + H+) 
               
               
                   
               
               
                 568  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(3-((1-(1-(tert- butyl)piperidin-4-yl)-1H-1,2,3- triazol-4-yl)((8-chloro-4-((3- chloro-4-fluorophenyl)amino)- 3-cyanoquinolin-6- yl)amino)methyl)phenyl)-N- methylmethanesulfonamide 
                 3 
                 ES/MS 750.1 (M + H+) 
               
               
                   
               
               
                 569  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((R)-1- phenylethyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 619.3 (M + H+) 
               
               
                   
               
               
                 570  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1- isopropyl-1H-1,2,3-triazol-4-yl) (3-(pyrrolidin-1- ylmethyl)phenyl)methyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 629.0 (M + H+) 
               
               
                   
               
               
                 571  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)((8- chloro-3-cyano-4-(((R)-1- phenylethyl)amino)quinolin-6- yl)amino)methyl)-N,N- dimethylbenzamide 
                 3 
                 ES/MS 690.1 (M + H+) 
               
               
                   
               
               
                 572  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)((8- chloro-3-cyano-4-((3,4-dichloro- 2-fluorophenyl)amino)quinolin- 6-yl)amino)methyl)-N,N- dimethylbenzamide 
                 3 
                 ES/MS 748.1 (M + H+) 
               
               
                   
               
               
                 573  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-(((8-chloro-3-cyano-4- ((3,4-dichloro-2- fluorophenyl)amino)quinolin- 6-yl)amino)(1H-1,2,3-triazol- 4-yl)methyl)-N,N- dimethylbenzamide 
                 15 
                 ES/MS 609.1 (M + H+) 
               
               
                   
               
               
                 574  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1S)- (1-(3-(oxetan-3-yl)-3- azabicyclo[3.1.0]hexan-6-yl)- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 641.1 (M + H+) 
               
               
                   
               
               
                 575  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((3- (pyrrolidin-1-ylmethyl)phenyl) (1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 587.2 (M + H+) 
               
               
                   
               
               
                 576  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1S)- (1-(3-ethyl-3-azabicyclo[3.1.0] hexan-6-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 613.1 (M + H+) 
               
               
                   
               
               
                 577  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((1S)-(1-(3- azabicyclo[3.1.0]hexan-6-yl)- 1H-1,2,3-triazo1-4- yl)(phenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 4 
                 ES/MS 585.1 (M + H+) 
               
               
                   
               
               
                 578  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-((S)-((8-chloro-3-cyano-4- (((R)-1-phenylethyl) amino)quinolin-6-yl) amino)(1H-1,2,3-triazol-4- yl)methyl)-N,N- dimethylbenzamide 
                 15 
                 ES/MS 551.0 (M + H+) 
               
               
                   
               
               
                 579  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-((S)-((8-chloro-3-cyano-4- (((R)-1-phenylethyl) amino)quinolin-6- yl)amino)(1-isopropyl-1H- 1,2,3-triazol-4-yl)methyl)- N,N-dimethylbenzamide 
                 3 
                 ES/MS 593.1 (M + H+) 
               
               
                   
               
               
                 580  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4- (morpholinoamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 600.3 (M + H+) 
               
               
                   
               
               
                 581  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((S)-2,3-dihydro-1H- inden-1-yl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 631.3 (M + H+) 
               
               
                   
               
               
                 582  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5,6- difluoropyridin-3-yl)amino)-6- ((phenyl(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 489.1 (M + H+) 
               
               
                   
               
               
                 583  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((R)-2,3-dihydro-1H- inden-1-yl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 631.3 (M + H+) 
               
               
                   
               
               
                 584  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 628.2 (M + H+) 
               
               
                   
               
               
                 585  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((R)-1-(o- tolyl)ethyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 633.3 (M + H+) 
               
               
                   
               
               
                 586  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((S)-sec-butyl)amino)-8-chloro- 6-(((S)-(1-isopropyl-1H-1,2,3- triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 474.1 (M + H+) 
               
               
                   
               
               
                 587  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((S)-sec-butyl)amino)-6- (((S)-(1-(1-(tert-butyl) piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloroquinoline-3-carbonitrile 
                 1 
                 ES/MS 571.3 (M + H+) 
               
               
                   
               
               
                 588  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-isopropyl- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-4- (((R)-1-phenylethyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 522.2 (M + H+) 
               
               
                   
               
               
                 589  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((R)-sec-butyl)amino)-8- chloro-6-(((S)-(1- isopropyl-1H-1,2,3- triazol-4-yl)(phenyl) methyl)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 474.2 (M + H+) 
               
               
                   
               
               
                 590  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((R)-sec-butyl)amino)-6-(((S)- (1-(1-(tert-butyl)piperidin-4-yl)- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloroquinoline-3-carbonitrile 
                 1 
                 ES/MS 571.3 (M + H+) 
               
               
                   
               
               
                 591  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-2- fluorophenyl)amino)-6-(((1- isopropyl-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 546.1 (M + H+) 
               
               
                   
               
               
                 592  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-isopropyl- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-4- (((R)-1-phenylpropyl) amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 536.2 (M + H+) 
               
               
                   
               
               
                 593  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((1S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3-(2- methylazetidine-1- carbonyl)phenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 20 
                 ES/MS 740.5 (M + H+) 
               
               
                   
               
               
                 594  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3-(3- hydroxyazetidine-1- carbonyl)phenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 20 
                 ES/MS 742.2 (M + H+) 
               
               
                   
               
               
                 595  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3- (dimethylamino)phenyl)methyl) amino)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 686.1 (M + H+) 
               
               
                   
               
               
                 596  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(bicyclo[2.2.1]heptan-2- ylamino)-6-(((S)-(1-(1-(tert- butyl)piperidin-4-yl)-1H-1,2,3- triazol-4- yl)(phenyl)methyl)amino)-8- chloroquinoline-3-carbonitrile 
                 1 
                 ES/MS 609.3 (M + H+) 
               
               
                   
               
               
                 597  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((1r,4S)-4- hydroxycyclohexyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 613.3 (M + H+) 
               
               
                   
               
               
                 598  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-((S)-((8-chloro-3-cyano-4- (((R)-1-phenylpropyl) amino)quinolin-6- yl)amino)(1H-1,2,3-triazol-4- yl)methyl)-N,N- dimethylbenzamide 
                 15 
                 ES/MS 565.5.0 (M + H+) 
               
               
                   
               
               
                 599  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-((S)-((8-chloro-3-cyano-4- (((R)-1-phenylpropyl) amino)quinolin-6- yl)amino)(1-isopropyl-1H- 1,2,3-triazol-4-yl) methyl)-N,N- dimethylbenzamide 
                 3 
                 ES/MS 607.5 (M + H+) 
               
               
                   
               
               
                 600  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)((8- chloro-3-cyano-4-(((R)-1- phenylpropyl)amino)quinolin-6- yl)amino)methyl)-N,N- dimethylbenzamide 
                 3 
                 ES/MS 704.5 (M + H+) 
               
               
                   
               
               
                 601  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((tetrahydro-2H-pyran- 4-yl)methyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 613.3 (M + H+) 
               
               
                   
               
               
                 602  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-chloro-4- ((cyclohexylmethyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 611.3 (M + H+) 
               
               
                   
               
               
                 603  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(piperidin-1- ylamino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 598.3 (M + H+) 
               
               
                   
               
               
                 604  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-(azepan-1-ylamino)-6- (((1-(1-(tert-butyl) piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloroquinoline-3-carbonitrile 
                 1 
                 ES/MS 612.3 (M + H+) 
               
               
                   
               
               
                 605  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1S)- phenyl(1-(3,3,3-trifluoro-2- hydroxypropyl)-1H-1,2,3-triazol- 4-yl)methyl)amino)quinoline-3- carbonitrile 
                 4 
                 ES/MS 616.2 (M + H+) 
               
               
                   
               
               
                 606  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-(((8-chloro-4-((3-chloro-2- fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(1H- 1,2,3-triazol-4-yl)methyl)-N,N- dimethylbenzamide 
                 15 
                 ES/MS 575.3 (M + H+) 
               
               
                   
               
               
                 607  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-(((8-chloro-4-((3-chloro-2- fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(1- isopropyl-1H-1,2,3-triazol-4- yl)methyl)-N,N- dimethylbenzamide 
                 3 
                 ES/MS 617.9 (M + H+) 
               
               
                   
               
               
                 608  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3- triazol-4-yl)((8- chloro-4-((3-chloro-2- fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino) methyl)-N,N- dimethylbenzamide 
                 3 
                 ES/MS 714.3 (M + H+) 
               
               
                   
               
               
                 609  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1- cyclopropyl-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 544.0 (M + H+) 
               
               
                   
               
               
                 610  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(2- hydroxy-2-methylpropyl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 4 
                 ES/MS 576.1 (M + H+) 
               
               
                   
               
               
                 611  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((2-chlorothiophen-3- yl)amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 631.2 (M + H+) 
               
               
                   
               
               
                 612  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((4-chlorothiophen-3- yl)amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 631.2 (M + H+) 
               
               
                   
               
               
                 613  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-2- fluorophenyl)amino)-6- ((phenyl(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 504.1 (M + H+) 
               
               
                   
               
               
                 614  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- hydroxyphenyl)amino)-6-(((4- chlorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 536.0 (M + H+) 
               
               
                   
               
               
                 615  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-4- yl)(phenyl)methyl)amino)-8- chloro-4-((1- methylcycloheptyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 625.3 (M + H+) 
               
               
                   
               
               
                 616  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((2- chlorobenzyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 639.2 (M + H+) 
               
               
                   
               
               
                 617  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((2,3- difluorobenzyl)amino)quinoline- 3-carbonitrile 
                 1 
                 ES/MS 641.3 (M + H+) 
               
               
                   
               
               
                 618  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((2- fluorobenzyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 623.3 (M + H+) 
               
               
                   
               
               
                 619  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((R)-1-(2- fluorophenyl)ethyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 637.3 (M + H+) 
               
               
                   
               
               
                 620  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3- (methylamino)phenyl)methyl) amino)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 24 
                 ES/MS 672.0 (M + H+) 
               
               
                   
               
               
                 621  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3-(3- methoxyazetidine-1- carbonyl)phenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 20 
                 ES/MS 756.2 (M + H+) 
               
               
                   
               
               
                 622  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3-(3- (dimethylamino)azetidine-1- carbonyl)phenyl)methyl)amino)- 8-chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 20 
                 ES/MS 769.2 (M + H+) 
               
               
                   
               
               
                 623  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(3-((1-(1-(tert- butyl)piperidin-4-yl)-1H-1,2,3- triazol-4-yl)((8-chloro-4-((3- chloro-4-fluorophenyl)amino)- 3-cyanoquinolin-6- yl)amino)methyl)phenyl)-N- methylacetamide 
                 3 
                 ES/MS 714.3 (M + H+) 
               
               
                   
               
               
                 624  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-N-(3-((1-(1-(tert- butyl)piperidin-4-yl)-1H-1,2,3- triazol-4-yl)((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl) amino)methyl)phenyl)acetamide 
                 3 
                 ES/MS 700.2 (M + H+) 
               
               
                   
               
               
                 625  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3,4-dichloro-2- fluorophenyl)amino)-6-(((1-(1- (oxetan-3-yl)piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 31 
                 ES/MS 677.1 (M + H+) 
               
               
                   
               
               
                 626  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((R)-phenyl(1H- 1,2,3-triazol-4-yl) methyl)amino)-4-(((R)- 1-phenylpropyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 494.1 (M + H+) 
               
               
                   
               
               
                 627  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-phenyl(1H- 1,2,3-triazol-4-yl) methyl)amino)-4-(((R)- 1-phenylpropyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 494.1 (M + H+) 
               
               
                   
               
               
                 628  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((3-chloro-2- fluorophenyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 643.2 (M + H+) 
               
               
                   
               
               
                 629  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((R)-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 633.3 (M + H+) 
               
               
                   
               
               
                 630  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3-(1- methyl-1H-imidazol-2-yl) phenyl)methyl)amino)-8-chloro- 4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 23 
                 ES/MS 723.2 (M + H+) 
               
               
                   
               
               
                 631  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- chlorophenyl)(1H-1,2,3-triazol- 4-yl)methyl)amino)-4-((2,3,4- trifluorophenyl)amino)quinoline- 3-carbonitrile 
                 15 
                 ES/MS 540.0 (M + H+) 
               
               
                   
               
               
                 632  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3- (thiazol-2-yl) phenyl)methyl)amino)-8-chloro- 4-((3-chloro-4- fluorophenyl)amino)quinoline- 3-carbonitrile 
                 23 
                 ES/MS 726.0 (M + H+) 
               
               
                   
               
               
                 633  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((R)-1-(3- fluorophenyl)ethyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 637.3 (M + H+) 
               
               
                   
               
               
                 634  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((R)-1-(4- fluorophenyl)ethyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 637.3 (M + H+) 
               
               
                   
               
               
                 635  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((1S,3S,5S,7S)-adamantan-2- yl)amino)-6-(((S)-(1-(1-(tert- butyl)piperidin-4-yl)-1H-1,2,3- triazol-4- yl)(phenyl)methyl)amino)-8- chloroquinoline-3-carbonitrile 
                 1 
                 ES/MS 649.4 (M + H+) 
               
               
                   
               
               
                 636  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-(((1R,3r,6S,8S)- tricyclo[4.3.1.13,8]undecan-3- yl)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 663.4 (M + H+) 
               
               
                   
               
               
                 637  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((3R,5R,7R)-adamantan-1- yl)amino)-6-(((S)-(1-(1-(tert- butyl)piperidin-4-yl)-1H-1,2,3- triazol-4- yl)(phenyl)methyl)amino)-8- chloroquinoline-3-carbonitrile 
                 1 
                 ES/MS 649.3 (M + H+) 
               
               
                   
               
               
                 638  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((1-benzyl-1H-indazol-5- yl)amino)-8-chloro-6-(((4- chlorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 616.2 (M + H+) 
               
               
                   
               
               
                 639  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((5-chloro-2- fluorophenyl)amino)-6-(((4- chlorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 538.0 (M + H+) 
               
               
                   
               
               
                 640  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- chlorophenyl)(1H-1,2,3-triazol- 4-yl)methyl)amino)-4-((2,6- difluorophenyl)amino)quinoline- 3-carbonitrile 
                 15 
                 ES/MS 522.1 (M + H+) 
               
               
                   
               
               
                 641  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((5-chlorothiophen-3- yl)amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 631.2 (M + H+) 
               
               
                   
               
               
                 642  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-((phenyl (1-(piperidin-4-yl)-1H-imidazo- 4-yl)methyl)amino)quinoline-3- carbonitrile 
                 27 
                 ES/MS 585.9 (M + H+) 
               
               
                   
               
               
                 643  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3- iodophenyl)methyl)amino)-8- chloro-4-43-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 769.0 (M + H+) 
               
               
                   
               
               
                 644  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3,4-dichloro-2- fluorophenyl)amino)-6- ((phenyl(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                   
               
               
                   
               
               
                 645  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3- (3,3-difluoroazetidine-1- carbonyl)phenyl)methyl)amino)- 8-chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 20 
                 ES/MS 762.3 (M + H+) 
               
               
                   
               
               
                 646  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3-(3- fluoroazetidine-1-carbonyl) phenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 20 
                 ES/MS 744.0 (M + H+) 
               
               
                   
               
               
                 647  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- chlorophenyl)(1H-1,2,3-triazol- 4-yl)methyl)amino)-4-((2,4,5- trifluorophenyl)amino)quinoline- 3-carbonitrile 
                 15 
                 ES/MS 540.0 (M + H+) 
               
               
                   
               
               
                 648  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((4-(benzyloxy)-3- chlorophenyl)amino)-8-chloro-6- (((4-chlorophenyl)(1H-1,2,3- triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 626.1 (M + H+) 
               
               
                   
               
               
                 649  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- ethoxyphenyl)amino)-6-(((4- chlorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 564.1 (M + H+) 
               
               
                   
               
               
                 650  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((2,3,4- trifluorophenyl)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 679.3 (M + H+) 
               
               
                   
               
               
                 651  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((2,4,5- trifluorophenyl)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 679.2 (M + H+) 
               
               
                   
               
               
                 652  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((5-chloro-2- fluorophenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 677.3 (M + H+) 
               
               
                   
               
               
                 653  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((2,6- difluorophenyl)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 661.2 (M + H+) 
               
               
                   
               
               
                 654  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((4-(benzyloxy)-3- chlorophenyl)amino)-6-(((1-(1- (tert-butyl)piperidin-4-yl)-1H- 1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloroquinoline-3-carbonitrile 
                 10 
                 ES/MS 765.3 (M + H+) 
               
               
                   
               
               
                 655  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3-chloro-4- ethoxyphenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 703.2 (M + H+) 
               
               
                   
               
               
                 656  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-phenyl(1H- 1,2,3-triazol-4-yl) methyl)amino)-4-(((R)- 1-phenylethyl)amino) quinoline-3-carbonitrile 
                 15 
                 ES/MS 480.2 (M + H+) 
               
               
                   
               
               
                 657  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- chlorophenyl)(1H-1,2,3-triazol- 4-yl)methyl)amino)-4-(((R)-1- phenylethyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 514.1 (M + H+) 
               
               
                   
               
               
                 658  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-(((S)-2- phenylpropyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 667.3 (M + H+) 
               
               
                   
               
               
                 659  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-(((R)-2- phenylpropyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 667.3 (M + H+) 
               
               
                   
               
               
                 660  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((5,6-difluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 662.2 (M + H+) 
               
               
                   
               
               
                 661  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3-chloro-4,5- difluorophenyl)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 695.2 (M + H+) 
               
               
                   
               
               
                 662  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((tetrahydro-2H-pyran-4- yl)amino)quinoline-3-carbonitrile 
                 1 
                 ES/MS 633.2 (M + H+) 
               
               
                   
               
               
                 663  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((1- methylcyclohexyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 645.3 (M + H+) 
               
               
                   
               
               
                 664  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((4,5-dichloro-2- fluorophenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 711.2 (M + H+) 
               
               
                   
               
               
                 665  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((2,3-dichloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 711.1 (M + H+) 
               
               
                   
               
               
                 666  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(3- fluoropropyl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 564.1 (M + H+) 
               
               
                   
               
               
                 667  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6- ((phenyl(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 504.1 (M + H+) 
               
               
                   
               
               
                 668  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-(4-(((8-chloro-4-((3-chloro- 4-fluorophenyl)amino)-3- cyanoquinolin-6- yl)amino)(phenyl)methyl)-1H- 1,2,3-triazol-1-yl)methyl pivalate 
                 15 
                 ES/MS 618.9 (M + H+) 
               
               
                   
               
               
                 669  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(2,2- difluoroethyl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 568.1 (M + H+) 
               
               
                   
               
               
                 670  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(3- hydroxypropyl)-1H-1,2,3-triazol- 4-yl)(phenyl)methyl) amino)quinoline- 3-carbonitrile 
                 3 
                 ES/MS 562.1 (M + H+) 
               
               
                   
               
               
                 671  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3- pivaloylphenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 21 
                 ES/MS 727.1 (M + H+) 
               
               
                   
               
               
                 672  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((1S)-(1-(1-(tert-butyl) piperidin-4-yl)-1H-1,2,3- triazol-4-yl)(3-(1- hydroxy-2,2- dimethylpropyl)phenyl)methyl) amino)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 22 
                 ES/MS 729.3 (M + H+) 
               
               
                   
               
               
                 673  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)((8- chloro-4-((3-chloro-4- fluorophenyl)amino)-3- cyanoquinolin-6- yl)amino)methyl)benzamide 
                 20 
                 ES/MS 686.1 (M + H+) 
               
               
                   
               
               
                 674  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)((8- chloro-4-((3-chloro-4- fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino) methyl)-N-ethyl-N- methylbenzamide 
                 20 
                 ES/MS 728.1 (M + H+) 
               
               
                   
               
               
                 675  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-(azetidine-1- carbonyl)phenyl)(1-(1-(tert- butyl)piperidin-4-yl)-1H-1,2,3- triazol-4-yl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline- 3-carbonitrile 
                 20 
                 ES/MS 726.0 (M + H+) 
               
               
                   
               
               
                 676  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3- (piperidine-1- carbonyl)phenyl)methyl)amino)- 8-chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline- 3-carbonitrile 
                 20 
                 ES/MS 754.1 (M + H+) 
               
               
                   
               
               
                 677  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-(((R)-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 667.3 (M + H+) 
               
               
                   
               
               
                 678  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((4- methylbenzyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 653.3 
               
               
                   
               
               
                 679  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3- methylbenzyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 653.3 (M + H+) 
               
               
                   
               
               
                 680  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((2- methylbenzyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 653.3 (M + H+) 
               
               
                   
               
               
                 681  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3- phenylpropyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 667.3 (M + H+) 
               
               
                   
               
               
                 682  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4- (isopropylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 591.2 (M + H+) 
               
               
                   
               
               
                 683  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-4- (butylamino)-8-chloroquinoline-3- carbonitrile 
                 1 
                 ES/MS 605.3 (M + H+) 
               
               
                   
               
               
                 684  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((4- ((dimethylamino)methyl)phenyl) amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 682.3 (M + H+) 
               
               
                   
               
               
                 685  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((S)-(1- ((3S,4R)-3-fluoropiperidin-4-yl)- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 5 
                 ES /MS 605.1 (M + H+) 
               
               
                   
               
               
                 686  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((1-benzyl-1H-indazol-5- yl)amino)-6-(((1-(1-(tert- butyl)piperidin-4-yl)-1H-1,2,3- triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloroquinoline-3-carbonitrile 
                 10 
                 ES/MS 755.4 (M + H+) 
               
               
                   
               
               
                 687  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3-chloro-2- methylphenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 673.2 (M + H+) 
               
               
                   
               
               
                 688  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- chlorophenyl)(1H-1,2,3-triazol- 4-yl)methyl)amino)-4-((3,4- dichlorophenyl)amino)quinoline- 3-carbonitrile 
                 15 
                 ES/MS 554.0 (M + H+) 
               
               
                   
               
               
                 689  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-4- ((3-chloro-4- fluorophenyl)amino)quinoline- 3,8-dicarbonitrile 
                 9 
                 ES/MS 669.2 (M + H+) 
               
               
                   
               
               
                 690  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)((8- chloro-4-((3-chloro-4- fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino) methyl)-N-methylbenzamide 
                 20 
                 ES/MS 700.0 (M + H+) 
               
               
                   
               
               
                 691  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3- (pyrrolidine-1- carbonyl)phenyl)methyl)amino)- 8-chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 20 
                 ES/MS 740.0 (M + H+) 
               
               
                   
               
               
                 692  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((5-chloropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 660.2 (M + H+) 
               
               
                   
               
               
                 693  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((5-chloro-2,4- difluorophenyl)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 695.2 (M + H+) 
               
               
                   
               
               
                 694  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3-chloro-2,6- difluorophenyl)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 695.2 (M + H+) 
               
               
                   
               
               
                 695  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3-chloro-2,4- difluorophenyl)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 695.2 (M + H+) 
               
               
                   
               
               
                 696  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3-chloro-5- fluorophenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 677.2 (M + H+) 
               
               
                   
               
               
                 697 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((1-(pyridin-2- yl)ethyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 655.2 (M + H+) 
               
               
                   
               
               
                 698  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4- ((cyclopropylmethyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 603.2 (M + H+) 
               
               
                   
               
               
                 699  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((1-(pyridin-3- yl)ethyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 654.2 (M + H+) 
               
               
                   
               
               
                 700  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- hydroxyphenyl)amino)-6-(((4- chlorophenyl)(1-(1-(oxetan-3- yl)piperidin-4-yl)-1H-1,2,3- triazol-4-yl)methyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 675.1 (M + H+) 
               
               
                   
               
               
                 701  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3-chloro-4- hydroxyphenyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 675.2 (M + H+) 
               
               
                   
               
               
                 702  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4- (cyclobutylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 603.2 (M + H+) 
               
               
                   
               
               
                 703  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4- (phenethylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 653.3 (M + H+) 
               
               
                   
               
               
                 704  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-(((R)-1- phenylethyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 653.3 (M + H+) 
               
               
                   
               
               
                 705  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-(((S)-1- phenylethyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 653.3 (M + H+) 
               
               
                   
               
               
                 706  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-(benzylamino)-6-(((1-(1- (tert-butyl)piperidin-4-yl)- 1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloroquinoline-3-carbonitrile 
                 1 
                 ES/MS 639.3 (M + H+) 
               
               
                   
               
               
                 707  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-(2,2,6,6- tetramethylpiperidin-4-yl)-1H- 1,2,3-triazol-4-yl)methyl) amino)-8- fluoroquinoline-3-carbonitrile 
                 10 
                 ES/MS 661.2 (M + H+) 
               
               
                   
               
               
                 708  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-(1-(oxetan-3- yl)piperidin-4-yl)-1H-1,2,3- triazol-4-yl)methyl) amino)-8- fluoroquinoline-3-carbonitrile 
                 10 
                 ES/MS 661.1 (M + H+) 
               
               
                   
               
               
                 709  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-4- ((3-chloro-4- fluorophenyl)amino)-8- fluoroquinoline-3-carbonitrile 
                 10 
                 ES/MS 661.1 (M + H+) 
               
               
                   
               
               
                 710     
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((3-(((2- (dimethylamino)ethyl)(methyl) amino)methyl)phenyl) (1-isopropyl-1H-1,2,3-triazol- 4-yl)methyl)amino) quinoline-3-carbonitrile 
                 18 
                 ES/MS 660.0 (M + H+) 
               
               
                   
               
               
                 711  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((3-(((2- (dimethylamino)ethyl)amino) methyl)phenyl)(1-isopropyl- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 18 
                 ES/MS 646.0 (M + H+) 
               
               
                   
               
               
                 712  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((3- ((dimethylamino)methyl) phenyl)(1- isopropyl-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 18 
                 ES/MS 602.8 (M + H+) 
               
               
                   
               
               
                 713  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((3- (hydroxymethyl)phenyl)(1- isopropyl-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 17 
                 ES/MS 576.2 (M + H+) 
               
               
                   
               
               
                 714  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4- (cyclopentylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 617.3 (M + H+) 
               
               
                   
               
               
                 715  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4- (cyclohexylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 631.3 (M + H+) 
               
               
                   
               
               
                 716  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4- (cycloheptylamino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 645.3 (M + H+) 
               
               
                   
               
               
                 717  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(isoxazol-5- yl)methyl)amino)quinoline-3- carbonitrile 
                 7 
                 ES/MS 522.1 (M + H+) 
               
               
                   
               
               
                 718  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(5-methyl-1,2,3- thiadiazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 7 
                 ES/MS 553.0 (M + H+) 
               
               
                   
               
               
                 719  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(2- (morpholinomethyl)phenyl) methyl) amino)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 18 
                 ES/MS 742.2 (M + H+) 
               
               
                   
               
               
                 720 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(2- ((dimethylamino)methyl) phenyl)methyl) amino)-8-chloro-4-((3-chloro- 4-fluorophenyl)amino)quinoline- 3-carbonitrile 
                 18 
                 ES/MS 700.3 (M + H+) 
               
               
                   
               
               
                 721  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-((phenyl (1-(pyridin-3-yl)-1H-1,2,3-triazol- 4-yl)methyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 581.0 (M + H+) 
               
               
                   
               
               
                 722  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(2- (hydroxymethyl)phenyl)methyl) amino)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 17 
                 ES/MS 673.1 
               
               
                   
               
               
                 723  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- chlorophenyl)(1-(1-(oxetan-3- yl)piperidin-4-yl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- ((3,4-difluorophenyl) amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 661.2 (M + H+) 
               
               
                   
               
               
                 724  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- chlorophenyl)(1-(2-(2- methoxyethoxy)ethyl)-1H-1,2,3- triazol-4-yl)methyl)amino)- 4-((3,4- difluorophenyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 624.1 (M + H+) 
               
               
                   
               
               
                 725  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((1-(1-(tert-butyl)piperidin-4- yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)(1-(4- chlorophenyl)prop-2-yn-1- yl)amino)-8-chloro-4-((5- chloropyridin-3-yl) amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 808.2 (M + H+) 
               
               
                   
               
               
                 726  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin-4-yl)-1H- 1,2,3-triazol-4-yl)(3-(((2- (dimethylamino)ethyl) amino)methyl)phenyl)methyl) amino)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 18 
                 ES/MS 743.2 (M + H+) 
               
               
                   
               
               
                 727  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3-(2- hydroxypropan-2- yl)phenyl)methyl)amino)- 8-chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 22 
                 ES/MS 701.1 (M + H+) 
               
               
                   
               
               
                 728  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 methyl (S)-3-((1-(1-(tert- butyl)piperidin-4-yl)-1H-1,2,3- triazol-4-yl)((8-chloro-4-((3- chloro- 4-fluorophenyl)amino)-3- cyanoquinolin-6- yl)amino)methyl)benzoate 
                 3 
                 ES/MS 701.2 (M + H+) 
               
               
                   
               
               
                 729  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-((phenyl (1-(pyridin-2-ylmethyl)-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 595.0 (M + H+) 
               
               
                   
               
               
                 730  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((3-(1,3-dioxolan-2- yl)phenyl)(1-methyl-1H-1,2,3- triazol-4-yl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 590.1 (M + H+) 
               
               
                   
               
               
                 731  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3,4-dichloro-2- fluorophenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 711.1 (M + H+) 
               
               
                   
               
               
                 732  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3,4-difluorophenyl) amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 661.2 (M + H+) 
               
               
                   
               
               
                 733  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(3- (morpholinomethyl)phenyl) methyl)amino)-8-chloro-4- ((3-chloro-4- fluorophenyl)amino)quinoline- 3-carbonitrile 
                 18 
                 ES/MS 744.0 (M + H+) 
               
               
                   
               
               
                 734  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(5-methyl-1,3,4- oxadiazol-2- yl)methyl)amino)quinoline-3- carbonitrile 
                 7 
                 ES/MS 537.0 (M + H+) 
               
               
                   
               
               
                 735  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- ((dimethylamino)methyl)phenyl) methyl)amino)-8-chloro-4- ((3-chloro-4-fluorophenyl) amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 700.1 (M + H+) 
               
               
                   
               
               
                 736  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1S)- (1-(5,5-difluoro-1- methylpiperidin-3- yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 5 
                 ES/MS 637.1 (M + H+) 
               
               
                   
               
               
                 737  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(2- morpholinoethyl)-1H-1,2,3- triazol-4-yl)(phenyl) methyl)amino)quinoline- 3-carbonitrile 
                 3 
                 ES/MS 617.0 (M + H+). 
               
               
                   
               
               
                 738  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(2- hydroxyethyl)-1H-1,2,3-triazol- 4-yl)(phenyl)methyl) amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 548.1 (M + H+) 
               
               
                   
               
               
                 739  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3-chloro-2- fluorophenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 677.1 (M + H+) 
               
               
                   
               
               
                 740  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((4- chlorophenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 661.2 (M + H+) 
               
               
                   
               
               
                 741  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-(m-tolylamino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 639.2 (M + H+) 
               
               
                   
               
               
                 742  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-(p-tolylamino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 639.2 (M + H+) 
               
               
                   
               
               
                 743  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((S)-(1- ((3R,4R)-1-ethyl-3- fluoropiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(phenyl)methyl) amino)quinoline-3-carbonitrile 
                 5 
                 ES/MS 633.1 (M + H+) 
               
               
                   
               
               
                 744  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((S)- (1-((3R,4R)-3- fluoropiperidin-4-yl)- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 5 
                 ES/MS 605.0 (M + H+) 
               
               
                   
               
               
                 745  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1S)- (1-(1-ethyl-5,5- difluoropiperidin-3- yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 5 
                 ES/MS 651.0 (M + H+) 
               
               
                   
               
               
                 746  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(2- morpholino-2-oxoethyl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 631.1 (M + H+) 
               
               
                   
               
               
                 747  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-((1- ethylazetidin-3-yl)methyl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 5 
                 ES/MS 601.1 (M + H+) 
               
               
                   
               
               
                 748  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1S)-(1- (5,5-difluoropiperidin-3-yl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 5 
                   
               
               
                   
               
               
                 749  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)(methyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 691.2 (M + H+) 
               
               
                   
               
               
                 750  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((6- (trifluoromethyl)pyridin-3- yl)amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 694.2 (M + H+) 
               
               
                   
               
               
                 751  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((2,4-dichloro-5- methoxyphenyl)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 723.2 (M + H+) 
               
               
                   
               
               
                 752  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((1-(2,2,2-trifluoroethyl)- 1H-pyrazol-3-yl)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 697.2 (M + H+) 
               
               
                   
               
               
                 753  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3- cyanophenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 650.2 (M + H+) 
               
               
                   
               
               
                 754  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((4-fluoro-3- (methylsulfonyl)phenyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 721.2 (M + H+) 
               
               
                   
               
               
                 755  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl) piperidin-4-yl)-1H-1,2,3- triazol-4-yl)(4-chlorophenyl) methyl)amino)-8- chloro-4-((4-chloro-3- fluorophenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 677.1 (M + H+) 
               
               
                   
               
               
                 756  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3,5- dichlorophenyl)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 695.1 (M + H+) 
               
               
                   
               
               
                 757  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((3-bromophenyl)amino)-6- (((1-(1-(tert-butyl)piperidin-4-yl)- 1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloroquinoline-3-carbonitrile 
                 10 
                 ES/MS 705.1 (M + H+) 
               
               
                   
               
               
                 758  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((2- chlorophenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 661.2 (M + H+) 
               
               
                   
               
               
                 759  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((4- (trifluoromethoxy)phenyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 709.2 (M + H+) 
               
               
                   
               
               
                 760  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-2-amino-6-(((1-(1-(tert- butyl)piperidin-4-yl)-1H-1,2,3- triazol-4-yl)(4- chlorophenyl)methyl)amino)-4- ((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 658.2 (M + H+) 
               
               
                   
               
               
                 761  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3- (difluoromethyl)phenyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 675.2 (M + H+) 
               
               
                   
               
               
                 762  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3- (trifluoromethyl)phenyl)amino) quinoline-3-carbonitrile 
                 10 
                 ES/MS 693.2 (M + H+) 
               
               
                   
               
               
                 763  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((3-bromo-4- fluorophenyl)amino)-6-(((1-(1- (tert-butyl)piperidin-4-yl)-1H- 1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloroquinoline-3-carbonitrile 
                 10 
                 ES/MS 721.1 (M + H+) 
               
               
                   
               
               
                 764  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3,5- difluorophenyl)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 661.2 (M + H+) 
               
               
                   
               
               
                 765  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3,4- dichlorophenyl)amino)quino1ine- 3-carbonitrile 
                 10 
                 ES/MS 695.1 (M + H+) 
               
               
                   
               
               
                 766  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((4- fluorophenyl)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 643.2 (M + H+) 
               
               
                   
               
               
                 767  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)- 8-chloro-4-((3- fluorophenyl)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 643.2 (M + H+) 
               
               
                   
               
               
                 768  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((2- fluorophenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 643.2 (M + H+) 
               
               
                   
               
               
                 769  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-4- ((3-chloro-4- fluorophenyl)amino)-7- methoxyquinoline-3-carbonitrile 
                 8 
                 ES/MS 673.2 (M + H+) 
               
               
                   
               
               
                 770  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3-chloro-4- cyanophenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 684.1 (M + H+) 
               
               
                   
               
               
                 771  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((5-fluoropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 644.2 (M + H+) 
               
               
                   
               
               
                 772  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-(pyridin-3- ylamino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 626.3 (M + H+) 
               
               
                   
               
               
                 773  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-methyl-1H- 1,2,3-triazol-4-yl) methyl)amino)-7- methylquinoline-3-carbonitrile 
                 8 
                 ES/MS 516.1 (M + H+) 
               
               
                   
               
               
                 774  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(2- ethyl-2-azaspiro[3.31heptan-6- yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 5 
                 ES/MS 627.1 (M + H+) 
               
               
                   
               
               
                 775  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(2-azaspiro[3.3] heptan-6- yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 5 
                 ES/MS 599.1 (M + H+) 
               
               
                   
               
               
                 776  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3- chlorophenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 659.2 (M + H+) 
               
               
                   
               
               
                 777  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-(phenylamino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 625.3 (M + H+) 
               
               
                   
               
               
                 778  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-((phenyl (1-(piperidin-4-yl)-1H-1,2,3- triazol-4-yl)methyl)amino) quinoline-3-carbonitrile 
                 5 
                 ES/MS 587.15 (M + H+) 
               
               
                   
               
               
                 779  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1 ethylpiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(phenyl)methyl) amino)quinoline-3-carbonitrile 
                 5 
                 ES/MS 581.2 (M + H+) 
               
               
                   
               
               
                 780  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((5-chloropyridin-3- yl)amino)quinoline-3-carbonitrile 
                 10 
                 ES/MS 626.2 (M + H+) 
               
               
                   
               
               
                 781  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((3,4-dichloro-2- fluorophenyl)amino)quinoline-3- carbonitrile 
                 10 
                 ES/MS 677.2 (M + H+) 
               
               
                   
               
               
                 782  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(thiazol-2- yl)methyl)amino)quinoline-3- carbonitrile 
                 7 
                 ES/MS 538.0 (M + H+) 
               
               
                   
               
               
                 783  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(oxazol-2- yl)methyl)amino)quinoline-3- carbonitrile 
                 7 
                 ES/MS 522.1 (M + H+) 
               
               
                   
               
               
                 784  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1,2,3-thiadiazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 7 
                 ES/MS 539.0 (M + H+) 
               
               
                   
               
               
                 785  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((3-(2H-1,2,3-triazol-2- yl)phenyl)amino)-6-(((1-(1-(tert- butyl)piperidin-4-yl)-1H-1,2,3- triazol-4- yl)(phenyl)methyl)amino)-8- chloroquinoline-3-carbonitrile 
                 10 
                 ES/MS 658.3 (M + H+) 
               
               
                   
               
               
                 786  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((3-chloro-4-(pyridin-2- ylmethoxy)phenyl)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 732.3 (M + H+) 
               
               
                   
               
               
                 787  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((3,4- difluorophenyl)amino)quinoline- 3-carbonitrile 
                 10 
                 ES/MS 627.3 (M + H+) 
               
               
                   
               
               
                 788  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((R)-(1- ((R)-2,2-dimethylpiperidin-4-yl)- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                 ES/MS 615.1 (M + H+) 
               
               
                   
               
               
                 789  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((R)-(1- ((R)-2,2-dimethylpiperidin-4-yl)- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                   
               
               
                   
               
               
                 790  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1S)-(1- (2,2-dimethylpiperidin-4-yl)-1H- 1,2,3-triazo1-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                   
               
               
                   
               
               
                 791  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4- yl)(phenyl)methyl)amino)-8- fluoroquinoline-3-carbonitrile 
                 5 
                 ES/MS 599.0 (M + H+) 
               
               
                   
               
               
                 792  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(ethyl((1- (1-ethylpiperidin-4-yl)-1H-1,2,3- triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 5 
                 ES/MS 643.2 (M + H+) 
               
               
                   
               
               
                 793  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(2- (dimethylamino)ethyl)-1H-1,2,3- triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 575.1 (M + H+) 
               
               
                   
               
               
                 794  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((3-chloro-4- fluorophenyl)amino)-8-fluoro-6- ((phenyl(1-(piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 5 
                   
               
               
                   
               
               
                 795  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(2- methoxyethyl)-1H-1,2,3- triazol-4-yl)(phenyl)methyl) amino)quinoline-3-carbonitrile 
                 3 
                 ES/MS 562.0 (M + H+) 
               
               
                   
               
               
                 796  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(2-aminoethyl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 547.0 (M + H+) 
               
               
                   
               
               
                 797  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(3- (dimethylamino)propyl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 589.0 (M + H+) 
               
               
                   
               
               
                 798  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-methyl-1H- 1,2,3-triazol-4-yl) methyl)amino)-7- methoxyquinoline-3-carbonitrile 
                 8 
                 ES/MS 532.1 (M + H+) 
               
               
                   
               
               
                 799  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(pyrimidin-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 7 
                 ES/MS 533.1 (M + H+) 
               
               
                   
               
               
                 800  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(pyrimidin-2- yl)methyl)amino)quinoline-3- carbonitrile 
                 7  
                 ES/MS 533.0 (M + H+) 
               
               
                   
               
               
                 801  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(pyrazin-2- yl)methyl)amino)quinoline-3- carbonitrile 
                 7 
                 ES/MS 533.1 (M + H+) 
               
               
                   
               
               
                 802  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-(1-(oxetan-3- yl)piperidin-4-yl)-1H-1,2,3- triazol-4-yl)methyl) amino)quinoline-3-carbonitrile 
                 5 
                 ES/MS 678.9 (M + H+) 
               
               
                   
               
               
                 803  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 679.2 (M + H+)  
               
               
                   
               
               
                 804  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((4-((3-chloro-4- fluorophenyl)amino)-3-cyano-8- fluoroquinolin-6- yl)amino)(phenyl)methyl)-1H- 1,2,3-triazol-1-yl)piperidine-1- carboxylate 
                 6 
                   
               
               
                   
               
               
                 805  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(4-methyl-1,2,5- oxadiazol-3- yl)methyl)amino)quinoline-3- carbonitrile 
                 7 
                 ES/MS 537.1 (M + H+) 
               
               
                   
               
               
                 806  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(thiazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 7 
                 ES/MS 538.0 (M + H+) 
               
               
                   
               
               
                 807  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(oxazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 7 
                 ES/MS 522.0 (M + H+) 
               
               
                   
               
               
                 808  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-((3-methyloxetan- 3-yl)methyl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 606.1 (M + H+) 
               
               
                   
               
               
                 809  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 tert-butyl (S)-4-(4-(((8-chloro-4- ((3-chloro-4-fluorophenyl) amino)-3-cyanoquinolin-6- yl)amino)(phenyl)methyl)-1H- 1,2,3-triazol-1-yl)piperidine-1- carboxylate 
                 3 
                 ES/MS 687.2 (M + H)+ 
               
               
                   
               
               
                 810  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-(oxetan-3-yl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 578.0 (M + H+) 
               
               
                   
               
               
                 811  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(tert-butyl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 3 
                 ES/MS 578.1 (M + H+) 
               
               
                   
               
               
                 812  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-(4-(((8-chloro-4-((3-chloro- 4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(4- fluorophenyl)methyl)-1H-1,2,3- triazol-1-yl)-3-methylbutanoic  acid 
                 3 
                 ES/MS 622.1 (M + H+) 
               
               
                   
               
               
                 813  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-(1-ethylpiperidin- 4-yl)-1H-1,2,3-triazol-4- yl)methyl)amino)-8- fluoroquinoline-3-carbonitrile 
                 5 
                 ES/MS 633.9 (M + H+) 
               
               
                   
               
               
                 814  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-(piperidin-4-yl)- 1H-1,2,3-triazol-4- yl)methyl)amino)-8- fluoroquinoline-3-carbonitrile 
                 5 
                   
               
               
                   
               
               
                 815  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1- (cyanomethyl)-1H-1,2,3-triazol- 4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 3 
                 ES/MS 560.9 (M + H+) 
               
               
                   
               
               
                 816  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((4-((3-chloro-4- fluorophenyl)amino)-3-cyano-8- fluoroquinolin-6-yl)amino)(4- chlorophenyl)methyl)-1H-1,2,3- triazol-1-yl)piperidine-1- carboxylate 
                 6 
                   
               
               
                   
               
               
                 817  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-(((R)-pyrrolidin- 2-yl)methyl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 605.1 (M + H+) 
               
               
                   
               
               
                 818  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (2R)-2-((4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)- 3-cyanoquinolin-6-yl)amino)(4- fluorophenyl)methyl)-1H-1,2,3- triazol-1-yl)methyl)-N,N- dimethylpyrrolidine-1- carboxamide 
                 6 
                   
               
               
                   
               
               
                 819  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 522.1 (M + H+) 
               
               
                   
               
               
                 820  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(naphthalen-2- yl)methyl)amino)quinoline-3- carbonitrile 
                 5 
                 ES/MS 665.5 (M + H+) 
               
               
                   
               
               
                 821  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- cyclopropylpiperidin-4-yl)-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 1 
                 ES/MS 645.1 (M + H+) 
               
               
                   
               
               
                 822  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1- (1-(3,3- difluorocyclobutyl)piperidin- 4-yl)- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 31 
                 ES/MS 695.1 (M + H+) 
               
               
                   
               
               
                 823  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6- (((1-(1-(2,2- difluoroethyl)piperidin- 4-yl)-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 35 
                 ES/MS 669.0 (M + H+) 
               
               
                   
               
               
                 824  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-2-(4-(4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(4- fluorophenyl)methyl)-1H-1,2,3- triazol-1-yl)piperidin-1-yl)-N,N- dimethylacetamide 
                 35 
                 ES/MS 690.3 (M + H+) 
               
               
                   
               
               
                 825  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-(1- isopropylpiperidin-4-yl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 1 
                 647.6 
               
               
                   
               
               
                 826  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-(1- methylpiperidin-4-yl)-1H-1,2,3- triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 31 
                 ES/MS 619.2 (M + H+) 
               
               
                   
               
               
                 827  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 5 
                   
               
               
                   
               
               
                 828  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-(1-(2,2,2- trifluoroethyl)piperidin-4-yl)-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 35 
                 ES/MS 688.1 (M + H+) 
               
               
                   
               
               
                 829  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1S)-(4- fluorophenyl)(1-(quinuclidin-3- yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 5 
                 ES/MS 631.2 (M + H+) 
               
               
                   
               
               
                 830  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 tert-butyl (S)-4-(4-(((8-chloro-4- ((3-chloro-4-fluorophenyl)amino)- 3-cyanoquinolin-6-yl)amino)(4- fluorophenyl)methyl)-1H-1,2,3- triazol-1-yl)piperidine-1- carboxylate 
                 31 
                 ES/MS 705.6 (M + H+) 
               
               
                   
               
               
                 831  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 643.2 (M + H+) 
               
               
                   
               
               
                 832  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                   
               
               
                   
               
               
                 833  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-bromo-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                 ES/MS 677.2 (M + H+) 
               
               
                   
               
               
                 834  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((4-((3-chloro-4- fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(4- fluorophenyl)methyl)-1H-1,2,3- triazol-1-yl)piperidine-1- carboxylate 
                 6 
                 ES/MS 705.9 (M + H+) 
               
               
                   
               
               
                 835  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((8-bromo-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(4- fluorophenyl)methyl)-1H-1,2,3- triazol-1-yl)piperidine-1- carboxylate 
                 6 
                   
               
               
                   
               
               
                 836  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 1 
                 ES/MS 662.1 (M + H+) 
               
               
                   
               
               
                 837  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((8-bromo-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(4- fluorophenyl)methyl)-1H-1,2,3- triazol-1-yl)piperidine-1- carboxylate 
                 6 
                   
               
               
                   
               
               
                 838  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethyl-2,2-dimethylpiperidin-4-yl)- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                   
               
               
                   
               
               
                 839  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(2,2- dimethylpiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                   
               
               
                   
               
               
                 840  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(3,3- dimethylpiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                 ES/MS 633.0 (M + H+) 
               
               
                   
               
               
                 841  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1- methyl- 1H-1,2,3-triazol-4-yl)(3- (pyrrolidin-1- ylmethyl)phenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                 ES/MS 601.0 (M + H+) 
               
               
                   
               
               
                 842  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (R)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6- (((1-methyl- 1H-1,2,3-triazol-4-yl)(3- (pyrrolidin-1- ylmethyl)phenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                 ES/MS 601.0 (M + H+) 
               
               
                   
               
               
                 843  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-(tetrahydro-2H- pyran-4-yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                   
               
               
                   
               
               
                 844  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((1-(1-acetylpiperidin-4-yl)- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 647.1 (M + H+) 
               
               
                   
               
               
                 845  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-(1- (methylsulfonyl)piperidin-4-yl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 683.1 (M + H+) 
               
               
                   
               
               
                 846  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-methy-1-1H- pyrazol-3- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 535.0 (M + H+) 
               
               
                   
               
               
                 847  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-methyl-1H- imidazol-2- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 534.9 (M + H+) 
               
               
                   
               
               
                 848  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6- yl)amino)(phenyl)methyl)-1H- 1,2,3-triazol-1-yl)piperidine-1- carboxylate 
                 6 
                   
               
               
                   
               
               
                 849  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (R)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                 ES/MS 633.1 (M + H+) 
               
               
                   
               
               
                 850 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (R)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-(piperidin-4-yl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 605.1 (M + H+) 
               
               
                   
               
               
                 851  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-(piperidin-4-yl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 605.1 (M + H+) 
               
               
                   
               
               
                 852  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6- (((1-methyl- 1H-1,2,3-triazol-4-yl)(3- (pyrrolidin-1- ylmethyl)phenyl)methyl) amino)quinoline-3-carbonitrile 
                 6 
                 ES/MS 604.1 (M + H+) 
               
               
                   
               
               
                 853  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-methyl-1H- pyrazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 535.1 (M + H+) 
               
               
                   
               
               
                 854  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(4-methyl-4H- 1,2,4-triazol-3- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 536.1 (M + H+) 
               
               
                   
               
               
                 855  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(4- fluorophenyl)methyl)-1H-1,2,3- triazol-1-yl)piperidine-1- carboxylate 
                 6 
                 ES/MS 738.8 (M + H+) 
               
               
                   
               
               
                 856  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (R)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-(1-ethylpiperidin- 4-yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 649.0 (M + H+) 
               
               
                   
               
               
                 857  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (R)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-(piperidin-4-yl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 620.4 (M + H+) 
               
               
                   
               
               
                 858  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-(1-ethylpiperidin- 4-yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 651.1 (M + H+) 
               
               
                   
               
               
                 859  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-(piperidin-4-yl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 621.2 (M + H+) 
               
               
                   
               
               
                 860  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl (R)-4-(4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(4- chlorophenyl)methyl)-1H-1,2,3- triazol-1-yl)piperidine-1- carboxylate 
                 6 
                 ES/MS 755.0 (M + H+) 
               
               
                   
               
               
                 861  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl (S)-4-(4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(4- chlorophenyl)methyl)-1H-1,2,3- triazol-1-yl)piperidine-1- carboxylate 
                 6 
                 ES/MS 756.4 (M + H+) 
               
               
                   
               
               
                 862  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(pyridin-3- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 531.5 (M + H+) 
               
               
                   
               
               
                 863  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl (3R)-3-(4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(4- fluorophenyl)methyl)-1H-1,2,3- triazol-1-yl)pyrrolidine-1- carboxylate 
                 6 
                 ES/MS 725.6 (M + H+) 
               
               
                   
               
               
                 864  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-((R)-pyrrolidin-3- yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                   
               
               
                   
               
               
                 865  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6- (((1-((R)-1- ethylpyrrolidin-3-yl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                   
               
               
                   
               
               
                 866  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl (3R)-3-(4-(((8-chloro- 4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(4- chlorophenyl)methyl)-1H-1,2,3- triazol-1-yl)pyrrolidine-1- carboxylate 
                 6 
                 ES/MS 741.2 (M + H+) 
               
               
                   
               
               
                 867  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-((R)-pyrrolidin- 3-yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 607.2 (M + H+) 
               
               
                   
               
               
                 868  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-((R)-1- ethylpyrrolidin-3-yl)-1H-1,2,3- triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 634.5 (M + H+) 
               
               
                   
               
               
                 869  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((3,4- difluorophenyl)(1-methyl-1H- imidazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 553.2 (M + H+) 
               
               
                   
               
               
                 870  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylazetidin-3-yl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                 ES/MS 605.0 (M + H+) 
               
               
                   
               
               
                 871  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-(1-ethylazetidin- 3-yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 620.8 (M + H+) 
               
               
                   
               
               
                 872  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((1-(azetidin-3-yl)-1H-1,2,3- triazol-4-yl)(4- chlorophenyl)methyl)amino)-8- chloro-4-((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 594.0 (M + H+) 
               
               
                   
               
               
                 873  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-((S)-pyrrolidin-3- yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 591.0 (M + H+) 
               
               
                   
               
               
                 874  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((3,5- bis(trifluoromethyl)phenyl)(1- (piperidin-4-yl)-1H-1,2,3-triazo1- 4-yl)methyl)amino)-8-chloro-4- ((3-chloro-4- fluorophenyl)amino)quinoline-3- carbonitrile 
                 6 
                   
               
               
                   
               
               
                 875  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1- (piperidin-4-yl)-1H-1,2,3-triazol- 4-yl)(3,4,5- trifluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                   
               
               
                   
               
               
                 876  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl (3S)-3-(4-(((8-chloro-4- ((3-chloro-4-fluorophenyl) amino)-3-cyanoquinolin-6- yl)amino)(4-fluorophenyl) methyl)-1H-1,2,3- triazol-1-yl)pyrrolidine-1- carboxylate 
                 6 
                 ES/MS 724.7 (M + H+) 
               
               
                   
               
               
                 877  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1- ((S)-1-ethylpyrrolidin- 3-yl)-1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                 ES/MS 619.0 (M + H+) 
               
               
                   
               
               
                 878  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl (3S)-3-(4-(((8-chloro- 4-((3-chloro-4-fluorophenyl) amino)-3-cyanoquinolin-6-yl) amino)(4-chlorophenyl) methyl)-1H-1,2,3- triazol-1-yl)pyrrolidine-1- carboxylate 
                 6 
                 ES/MS 742.8 (M + H+) 
               
               
                   
               
               
                 879  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-((S)-1- ethylpyrrolidin-3-yl)-1H-1,2,3- triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 635.0 ES/MS (M + H+) 
               
               
                   
               
               
                 880  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-((S)-pyrrolidin- 3-yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 606.7 (M + H+) 
               
               
                   
               
               
                 881  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-methyl-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 553.6 (M + H+) 
               
               
                   
               
               
                 882  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-methyl-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 536.0 (M + H+) 
               
               
                   
               
               
                 883  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(4- fluoro-2-methylphenyl)methyl)- 1H-1,2,3-triazol-1-yl) piperidine-1-carboxylate 
                 6 
                   
               
               
                   
               
               
                 884  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluoro-2-methylphenyl) (1-(piperidin-4-yl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 619.1 (M + H+) 
               
               
                   
               
               
                 885  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(4-fluoro-2- methylphenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                   
               
               
                   
               
               
                 886  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-(piperidin-4- yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 607.3 (M + H+), 602.9 (M − H−) 
               
               
                   
               
               
                 887  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1-methyl-1H- imidazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 535.4 (M + H+) 
               
               
                   
               
               
                 888  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6- ((phenyl(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 504.0 (M + H+) 
               
               
                   
               
               
                 889  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(3,4,5- trifluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                   
               
               
                   
               
               
                 890  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(3,4,5- trifluorophenyl)methyl)-1H-1,2,3- triazol-1-yl)piperidine-1- carboxylate 
                 6 
                   
               
               
                   
               
               
                 891  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((3,4- difluorophenyl)(1-methyl-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 554.1 (M + H+) 
               
               
                   
               
               
                 892  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((3,4- dichlorophenyl)(1-methyl-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 588.1 (M + H+) 
               
               
                   
               
               
                 893  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- fluorophenyl)(1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 15 
                 ES/MS 522.0 (M + H+) 
               
               
                   
               
               
                 894  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-methyl-1H- imidazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 551.1 (M + H+) 
               
               
                   
               
               
                 895  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6- (((1-methyl- 1H-imidazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                 ES/MS 516.9 (M + H+) 
               
               
                   
               
               
                 896  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(4- (trifluoromethoxy)phenyl)methyl)- 1H-1,2,3-triazol-1-yl)piperidine-1- carboxylate 
                 6 
                   
               
               
                   
               
               
                 897  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1- (piperidin-4-yl)-1H-1,2,3- triazol-4-yl)(4- (trifluoromethoxy)phenyl) methyl)amino)quinoline-3- carbonitrile 
                 6 
                   
               
               
                   
               
               
                 898  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(4- (trifluoromethoxy)phenyl) methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 698.9 (M + H+) 
               
               
                   
               
               
                 899  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(3,4- difluorophenyl)methyl)-1H-1,2,3- triazol-1-yl)piperidine-1- carboxylate 
                 6 
                   
               
               
                   
               
               
                 900  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((3,4- difluorophenyl)(1-(piperidin-4- yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 620.9 (M + H+) 
               
               
                   
               
               
                 901  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((3,4- difluorophenyl)(1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                   
               
               
                   
               
               
                 902  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(3- methoxyphenyl)methyl)-1H-1,2,3- triazol-1-yl)piperidine-1- carboxylate 
                 6 
                   
               
               
                   
               
               
                 903  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((3- methoxyphenyl)(1-(piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                   
               
               
                   
               
               
                 904  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(3- methoxyphenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                   
               
               
                   
               
               
                 905  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(3- fluorophenyl)methyl)-1H-1,2,3- triazol-1-yl)piperidine-1- carboxylate 
                 6 
                 ES/MS 738.9 (M + H+) 
               
               
                   
               
               
                 906  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((3- fluorophenyl)(1-(piperidin-4-yl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                   
               
               
                   
               
               
                 907  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(3- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                   
               
               
                   
               
               
                 908  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                 ES/MS 635.2 (M + H+), 631.0 (M − H−) 
               
               
                   
               
               
                 909  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(3,4- dichlorophenyl)methyl)-1H-1,2,3- triazol-1-yl)piperidine-1- carboxylate 
                 6 
                   
               
               
                   
               
               
                 910  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((3,4- dichlorophenyl)(1-(piperidin- 4-yl)-1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 654.7 (M + H+) 
               
               
                   
               
               
                 911  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((3,4- dichlorophenyl)(1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                 ES/MS 683.0 (M + H+) 
               
               
                   
               
               
                 912  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(4-(((8-chloro-4-((3-chloro-4- fluorophenyl)amino)-3- cyanoquinolin-6- yl)amino)(phenyl)methyl)-1H- 1,2,3-triazol-1-yl)acetic acid 
                 6 
                 ES/MS 561.4 (M + H+) 
               
               
                   
               
               
                 913  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)amino)(4- chlorophenyl)methyl)-1H-1,2,3- triazol-1-yl)piperidine-1- carboxylate 
                 6 
                   
               
               
                   
               
               
                 914  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((4- chlorophenyl)(1-(piperidin-4-yl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                   
               
               
                   
               
               
                 915  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 benzyl 4-(4-(((8-chloro-4-((3- chloro-4-fluorophenyl)amino)-3- cyanoquinolin-6-yl)aminoXp- tolyl)methyl)-1H-1,2,3-triazol-1- yl)piperidine-1-carboxylate 
                 6 
                   
               
               
                   
               
               
                 916  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1- (piperidin-4-yl)-1H-1,2,3-triazol- 4-yl)(p-tolyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                 ES/MS 601.0 (M + H+) 
               
               
                   
               
               
                 917  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4-yl)(p- tolyl)methyl)amino)quinoline-3- carbonitrile 
                 6 
                   
               
               
                   
               
               
                 918  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (R)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                 ES/MS 615.2 (M + H+) 
               
               
                   
               
               
                 919  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                 ES/MS 614.7 (M + H+) 
               
               
                   
               
               
                 920  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6- (((1-methyl- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                 ES/MS 518.1 (M + H+) 
               
               
                   
               
               
                 921  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-((phenyl (1-(piperidin-4-yl)-1H- 1,2,3-triazol-4-yl)methyl) amino)quinoline-3-carbonitrile 
                 6 
                 ES/MS 584.7 (M − H−) 
               
               
                   
               
               
                 922  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((3-chloro-4- fluorophenyl)amino)-6-(((1-(1- ethylpiperidin-4-yl)-1H-1,2,3- triazol-4- yl)(phenyl)methyl)amino) quinoline-3-carbonitrile 
                 6 
                 ES/MS 615.4 (M + H+) 
               
               
                   
               
               
                 923  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (phosphonooxy)methyl (S)-(8- chloro-3-cyano-4- (neopentylamino)quinolin-6-yl) ((1-cyclopropyl-1H- 1,2,3-triazol-4-yl) (4-fluorophenyl)methyl- d)carbamate 
                   
                 ES/MS 659.0 (M + H+) 
               
               
                   
               
               
                 924  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (phosphonooxy)methyl (S)- (benzo[d]thiazol-7-yl(1-(1- (trifluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4- yl)methyl)(3,8-dicyano-4- (neopentylamino)quinolin-6- yl)carbamate 
                   
                   
               
               
                   
               
               
                 925  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(((R)-3-methoxy-1- phenylpropyl)amino)quinoline- 3-carbonitrile 
                 1 
                 583.37 
               
               
                   
               
               
                 926  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-((bicyclo[1.1.1]pentan-1- ylmethyl)amino)-8-chloro-6-(((3- cyanophenyl)(1-cyclopropyl-1H- 1,2,3-triazol-4-yl)methyl- d)amino)quinoline-3-carbonitrile 
                 10 
                 522.30 
               
               
                   
               
               
                 927  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((bicyclo[1.1.1]pentan-1- ylmethyl)amino)-8-chloro-6-(((1- cyclopropyl-1H-1,2,3-triazol-4- fluorophenyl)methyl)amino) quinoline-3-carbonitrile 
                 10 
                 514.40 
               
               
                   
               
               
                 928  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((bicyclo[1.1.1]pentan-1- ylmethyl)amino)-8-chloro-6-(((2- chlorophenyl)(1-cyclopropyl-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 10 
                 530.50 
               
               
                   
               
               
                 929  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-(tert-butyl)piperidin- 4-yl)-1H-1,2,3-triazol-4-yl)(4- chlorophenyl)methyl-d)amino)-8- chloro-4- (neopentylamino)quinoline-3- carbonitrile 
                 3 
                 620.20 
               
               
                   
               
               
                 930  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-bromo-6-(((S)-(2- chlorophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4-yl) methyl-d)amino)- 4-(((R)-3-cyano-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 2 
                 640.35 
               
               
                   
               
               
                 931  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 8-(methylsulfonyl)-4- (neopentylamino)quinoline-3- carbonitrile 
                 58 
                 549.43 
               
               
                   
               
               
                 932  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(((R)-3-(methylsulfonyl)-1- phenylpropyl)amino)quinoline- 3-carbonitrile 
                 1 
                 631.10 
               
               
                   
               
               
                 933 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(naphthalen-1-ylamino) quinoline-3-carbonitrile 
                 3 
                 561.30 
               
               
                   
               
               
                 934  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-2- cyanophenyl)amino)-6-(((1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 3 
                 570 
               
               
                   
               
               
                 935  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-2- (methylsulfonyl)phenyl) amino)-6-(((1-cyclopropyl- 1H-1,2,3-triazol- 4-yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 3 
                 623 
               
               
                   
               
               
                 936  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- chlorophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4- yl)methyl-d)amino)- 4-(neopentylamino) quinoline-3-carbonitrile 
                 3 
                 521.20 
               
               
                   
               
               
                 937  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-bromo-4-(((R)-3-cyano-1- phenylpropyl)amino)-6-(((S)-(1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 2 
                 622.09 
               
               
                   
               
               
                 938  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-(((R)-3-cyano-1- phenylpropyl)amino)-6-(((S)- (4-fluorophenyl)(1-(1- (trifluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4-yl)methyl- d)amino)quinoline-3-carbonitrile 
                 2 
                 646.20 
               
               
                   
               
               
                 939  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-acetyl-6-(((S)-(2- chlorophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4-yl) methyl-d)amino)- 4-(((R)-3-cyano-1- phenylpropyl)amino) quinoline-3-carbonitrile 
                 14 
                 602.33 
               
               
                   
               
               
                 940  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-bromo-6-(((S)-(1- cyclopropyl-1H-1,2,3-triazol- 4-yl)(3-(oxazol-2-yl) phenyl)methyl)amino)-4- (((R)-1-phenylpropyl)amino) quinoline-3-carbonitrile 
                 3 
                 647.10 
               
               
                   
               
               
                 941  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-cyclopropyl-1H- 1,2,3-triazol-4-yl) (3-(oxazol-2-yl)phenyl) methyl)amino)-4-(((R)-1- phenylpropyl)amino) quinoline-3,8-dicarbonitrile 
                 9 
                 592.10 
               
               
                   
               
               
                 942  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-((S)-(1-cyclopropyl-1H- 1,2,3-triazol-4-yl) ((3,8-dicyano-4-(((R)- 1-phenylpropyl)amino) quinolin-6-yl)amino) methyl)benzamide 
                 20 
                 568.10 
               
               
                   
               
               
                 943  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(3-(3,3- difluoroazetidine-1- carbonyl)phenyl)methyl) amino)-4-(((R)-1- phenylpropyl)amino)quinoline- 3,8-dicarbonitrile 
                 20 
                 644.10 
               
               
                   
               
               
                 944  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-((S)-((8-bromo-3-cyano- 4-(((R)-1-phenylpropyl) amino)quinolin-6-yl) amino)(1-cyc1opropyl-1H- 1,2,3-triazol-4-yl) methyl)benzamide 
                 20 
                 621.20 
               
               
                   
               
               
                 945  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(2-chlorophenyl)(1- cyclopropyl-1H-1,2,3-triazol-4- yl)methyl)amino)-4-(((R)-3- cyano-1-phenylpropyl) amino)quinoline- 3,8-dicarbonitrile 
                 9 
                 584.10 
               
               
                   
               
               
                 946  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((2-acetyl-3- chlorophenyl)amino)-8- chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl) (4-fluorophenyl)methyl- d)amino)quinoline-3- carbonitrile 
                 56 
                 587.40 
               
               
                   
               
               
                 947  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3- chlorophenyl)amino)-6- (((1-cyclopropyl- 1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl-d) amino)quinoline-3-carbonitrile 
                 56 
                 545.20 
               
               
                   
               
               
                 948  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-((S)-(1-cyclopropyl-1H- 1,2,3-triazol-4-yl) ((3,8-dicyano-4-(((R)- 1-phenylpropyl)amino) quinolin-6-yl)amino) methyl)-N-methylbenzamide 
                 20 
                 582.10 
               
               
                   
               
               
                 949  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((R)-3-cyano-1- phenylpropyl)amino)-6- (((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3,8-dicarbonitrile 
                 9 
                 550.2 
               
               
                   
               
               
                 950  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (R)-4-((3-cyano-6-(((S)-(1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)-8-(pyrimidin-5- yl)quinolin-4-yl)amino)-4- phenylbutanoic acid 
                 12 
                 641.16 
               
               
                   
               
               
                 951  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (R)-4-((6-(((S)-(2- chlorophenyl)(1-cyclopropyl- 1H-1,2,3-triazol-4- yl)methyl-d)amino)-3-cyano- 8-(pyrimidin-5-yl)quinolin- 4-yl)amino)-4-phenylbutanoic  acid 
                 12 
                 657.09 
               
               
                   
               
               
                 952  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(1-(1- cyanocyclobutyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 9 
                 550.20 
               
               
                   
               
               
                 953  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(1- cyclopropyl-1H-1,2,3-triazol-4- yl)methyl-d)amino)-8-iodo-4- (neopentylamino)quinoline-3- carbonitrile 
                 1 
                 613.07 
               
               
                   
               
               
                 954  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- chlorophenyl)(1-(1-ethylpiperidin- 4-yl)-1H-1,2,3-triazol-4- yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 20 
                 591.21 
               
               
                   
               
               
                 955  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- chlorophenyl)(1-(1-ethylpiperidin- 4-yl)-1H-1,2,3-triazol-4- yl)methyl)amino)-4-(((R)-3-cyano- 1-phenylpropyl)amino)quinoline- 3-carbonitrile 
                 20 
                 664.04 
               
               
                   
               
               
                 956  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(1-(1- cyanocyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 9 
                 536.30 
               
               
                   
               
               
                 957  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-1-(4-((2-chlorophenyl)((3,8- dicyano-4- (neopentylamino)quinolin-6- yl)amino)methyl)-1H-1,2,3-triazol- 1-yl)cyclopropane-1-carboxamide 
                 9 
                 554.40 
               
               
                   
               
               
                 958  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((1-([1,1&#39;-bi(cyclopropan)]-1-yl)- 1H-1,2,3-triazol-4-yl)(2- chlorophenyl)methyl-d)amino)-8- chloro-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 561.40 
               
               
                   
               
               
                 959  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl)(1-(1- (pyridin-2-yl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl-d)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 598.40 
               
               
                   
               
               
                 960  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl)(1-(1- (pyridin-3-yl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl-d)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 598.50 
               
               
                   
               
               
                 961  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-(((R)-3-cyano-1- phenylpropyl)amino)-6-(((S)- (1-(1-cyanocyclopropyl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino) quinoline-3,8-dicarbonitrile 
                 9 
                 575.2 
               
               
                   
               
               
                 962  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(1-(1- methylcyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 9 
                 525.30 
               
               
                   
               
               
                 963  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-2-(4-((2-chlorophenyl) ((3,8-dicyano-4- (neopentylamino)quinolin-6- yl)amino)methyl)-1H-1,2,3- triazol-1-yl)acetamide 
                 9 
                 528.20 
               
               
                   
               
               
                 964  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-(1-(hydroxymethyl) cyclopropyl)-1H-1,2,3- triazo1-4-yl)methyl-d)amino)- 4-(neopentylamino)quinoline- 3-carbonitrile 
                 4 
                 551.20 
               
               
                   
               
               
                 965  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((2-chlorophenyl) (1-(3-(hydroxymethyl) oxetan-3-yl)-1H- 1,2,3-triazol-4-yl)methyl-d) amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 4 
                 567.20 
               
               
                   
               
               
                 966  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-((3-chloro-2- (trifluoromethoxy)phenyl) amino)-6-(((1- cyclopropyl-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl- d)amino)quinoline-3- carbonitrile 
                 3 
                 629.30 
               
               
                   
               
               
                 967  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(difluoromethyl) cyclopropyl)amino) quinoline-3-carbonitrile 
                 3 
                 525.30 
               
               
                   
               
               
                 968  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((4-fluorophenyl)(1-(1- (pyridin-2-yl)cyclopropyl)-1H- 1,2,3-triazo1-4-yl)methyl)amino)- 4-(neopentylamino) quinoline-3,8-dicarbonitrile 
                 9 
                 572.20 
               
               
                   
               
               
                 969  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 1-(4-((3-cyanophenyl)((3,8- dicyano-4- (neopentylamino)quinolin-6- yl)amino)methyl-d)-1H-1,2,3- triazol-1-yl)cyclopropane-1- carboxamide 
                 9 
                 546.30 
               
               
                   
               
               
                 970  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-2-(4-(((8-chloro-3-cyano-4- (neopentylamino)quinolin-6- yl)amino)(phenyl)methyl)-1H- 1,2,3-triazol-1-yl)-2,2- difluoroacetamide 
                 1 
                 539.10 
               
               
                   
               
               
                 971  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-2-(4-(((8-chloro-3-cyano-4- (neopentylamino)quinolin-6- yl)amino)(3-cyanophenyl)methyl- d)-1H-1,2,3-triazol-1-yl)-2,2- difluoroacetamide 
                 3 
                 565.10 
               
               
                   
               
               
                 972  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2-(4-((S)-((8-chloro-3-cyano-4- (((R)-1-phenylpropyl) amino)quinolin-6-yl)amino) (2-chlorophenyl)methyl)- 1H-1,2,3-triazol-1-yl)-2,2- difluoroacetamide 
                 3 
                 621.10 
               
               
                   
               
               
                 973  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-([1,1&#39;-bi (cyclopropan)]-1-yl)-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)- 4-(neopentylamino) quinoline-3,8-dicarbonitrile 
                 9 
                 535.20 
               
               
                   
               
               
                 974  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((4-fluorophenyl)(1-(1- (pyridin-3-yl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino) quinoline-3,8-dicarbonitrile 
                 9 
                 572.20 
               
               
                   
               
               
                 , 
                   
                   
                   
                   
               
               
                   
               
               
                 975  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-1-(4-(((3,8-dicyano-4- (neopentylamino)quinolin-6- yl)amino)(phenyl)methyl)-1H- 1,2,3-triazol-1-yl)cyclopropane-1- carboxamide 
                 9 
                 520.20 
               
               
                   
               
               
                 976  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-cyanocyclopropyl)- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 9 
                 520.20 
               
               
                   
               
               
                 977  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-1-(4-(((3,8-dicyano-4- (neopentylamino)quinolin-6- yl)amino)(4-fluorophenyl) methyl)-1H-1,2,3-triazol- 1-yl)cyclopropane- 1-carboxamide 
                 9 
                 538.20 
               
               
                   
               
               
                 978  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((4-fluorophenyl)(1-(1- methylcyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 9 
                 509.30 
               
               
                   
               
               
                 979  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((4-fluorophenyl)(1-(1- (hydroxymethyl)cyclopropyl)- 1H-1,2,3-triazol-4-yl) methyl)amino)-4- (neopentylamino)quinoline- 3,8-dicarbonitrile 
                 9 
                 525.20 
               
               
                   
               
               
                 980  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(4- chlorophenyl)(1-((1R,5S,6s)-3- cyclopropyl-3-azabicyclo [3.1.0]hexan-6-yl)-1H- 1,2,3-triazol-4-yl)methyl-d) amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 55 
                 602.30 
               
               
                   
               
               
                 981  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-4-((4-cyna-1- phenylbutyl)amino)-6-(((1- cyclopropyl-1H-1,2,3-triazol-4- yl)(4-fluorophenyl)methyl- d)amino)quinoline-3-carbonitrile 
                 1 
                 593.22 
               
               
                   
               
               
                 982  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- chlorophenyl)(1-(1- cyclopropylpiperidin-4-yl)- 1H-1,2,3-triazol-4-yl) methyl-d)amino)- 4-(neopentylarnino) quinoline-3-carbonitrile 
                 4 
                 604.30 
               
               
                   
               
               
                 983  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((4-fluorophenyl)(1- (1-(pyridin-4-yl) cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl) amino)-4-(neopentylamino) quinoline-3,8-dicarbonitrile 
                 57 
                 572.3 
               
               
                   
               
               
                 984  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((4-fluorophenyl)(1- (1-(pyrazin-2-yl) cyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline- 3,8-dicarbonitrile 
                 57 
                 573.2 
               
               
                   
               
               
                 985  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-1-(4-(((3,8-dicyano-4- (neopentylamino)quinolin-6- yl)amino)(4-fluorophenyl) methyl)-1H-1,2,3-triazol-1- yl)cyclobutane-1-carboxamide 
                 57 
                 552.3 
               
               
                   
               
               
                 986  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-4- (((S)-2,2-difluoro-3-hydroxy-1- phenylpropyl)amino)quinoline- 3-carbonitrile 
                 2 
                 586.2 
               
               
                   
               
               
                 987  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((4-fluorophenyl)(1-(1- (pyridazin-3-yl)cyclopropyl)- 1H-1,2,3-triazol-4-yl) methyl)amino)-4- (neopentylamino)quinoline- 3,8-dicarbonitrile 
                 57 
                 573.2 
               
               
                   
               
               
                 988  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-bromo-6-(((1S)-(1-(3-(tert- butylamino)-2-hydroxypropyl)- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 46 
                 637.90 
               
               
                   
               
               
                 989  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(1- cyanocyclopropyl)-1H-1,2,3- triazol-4-yl)(4- fluorophenyl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 529.20 
               
               
                   
               
               
                 990  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1-(1- methylcyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 518.3 
               
               
                   
               
               
                 991  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1-(1-(pyridin-2- yl)cyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 581.2 
               
               
                   
               
               
                 992  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-1-(4-(((8-chloro-3-cyano- 4-(neopentylamino)quinolin- 6-yl)amino)(4-fluorophenyl) methyl)-1H-1,2,3-triazol-1-yl) cyclobutane-1-carboxamide 
                 4 
                 561.30 
               
               
                   
               
               
                 993  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((1S)-(1-(2-(1-(tert- butyl)aziridin-2-yl)ethyl)- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(neopentylamino) quinoline-3,8-dicarbonitrile 
                 9 
                 581.40 
               
               
                   
               
               
                 994  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((4-fluorophenyl)(1- (pyridin-3-yl)-1H-1,2,3- triazol-4-yl)methyl-d)amino)- 4-(neopentylamino) quinoline-3,8-dicarbonitrile 
                 9 
                 533.40 
               
               
                   
               
               
                 995  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-cyano-2- methylphenyl)(1-(1- (trifluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4-yl) methyl)amino)-4- (neopentylamino)quinoline- 3,8-dicarbonitrile 
                 9 
                 584.30 
               
               
                   
               
               
                 996  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-1-(4-(((8-chloro-3-cyano- 4-(neopentylamino)quinolin- 6-yl)amino)(4-fluorophenyl) methyl)-1H-1,2,3-triazol- 1-yl)cyclopropane-1- carboxamide 
                 4 
                 547.3 
               
               
                   
               
               
                 997  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1-(1-(pyridin- 3-yl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl) amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 4 
                 581.2 
               
               
                   
               
               
                 998  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- fluorophenyl)(1-(1- (trifluoromethyl)cyclobutyl)- 1H-1,2,3-triazol-4-yl) methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 586.2 
               
               
                   
               
               
                 999  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-1-(4-((2-chlorophenyl)((3- cyano-8-fluoro-4- (neopentylamino)quinolin-6- yl)amino)methyl)-1H-1,2,3- triazol-1-yl)cyclopropane- 1-carboxamide 
                 4 
                 547.2 
               
               
                   
               
               
                 1000  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(1-(1- cyanocyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-8- fluoro-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 529.2 
               
               
                   
               
               
                 1001  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-2-(4-((2-chlorophenyl)((3- cyano-8-fluoro-4- (neopentylamino)quinolin-6- yl)amino)methyl)-1H-1,2,3- triazol-1-yl)-2,2- difluoroacetamide 
                 1 
                 557.1 
               
               
                   
               
               
                 1002  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(2,2- difluoroethyl)-1H-1,2,3- triazol-4-yl) (4-fluorophenyl)methyl) amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 4 
                 528.2 
               
               
                   
               
               
                 1003  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(naphthalen- 1-yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 3 
                 536.4 
               
               
                   
               
               
                 1004  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(1- (pyridin-3-yl)-1H-1,2,3-triazol- 4-yl)methyl-d)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 9 
                 549.3 
               
               
                   
               
               
                 1005  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-cyanophenyl)(1- (pyridin-3-yl)-1H-1,2,3- triazol-4-yl)methyl-d)amino)- 4-(neopentylamino) quinoline-3,8-dicarbonitrile 
                 9 
                 540.3 
               
               
                   
               
               
                 1006  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1- (fluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-(neopentylamino)quinoline- 3,8-dicarbonitrile 
                 9 
                 528.3 
               
               
                   
               
               
                 1007  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-cyanophenyl)(1-(1- (fluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4-yl) methyl-d)amino)- 4-(neopentylamino)quinoline- 3,8-dicarbonitrile 
                 9 
                 535.3 
               
               
                   
               
               
                 1008  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-1-(4-(((8-chloro-3-cyano-4- (neopentylamino)quinolin-6- yl)amino)(3-cyano-2- methylphenyl)methyl)-1H-1,2,3- triazol-1-yl)cyclopropane-1- carboxamide 
                 4 
                 568.3 
               
               
                   
               
               
                 1009  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-1-(4-(((8-chloro-3-cyano-4- (neopentylamino)quinolin-6- yl)amino)(3-cyano-2- methylphenyl)methyl)-1H-1,2,3- triazol-1-yl)cyclobutane-1- carboxamide 
                 4 
                 582.3 
               
               
                   
               
               
                 1010  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- chlorophenyl)(1-(quinuclidin- 4-yl)-1H-1,2,3-triazol-4-yl) methyl-d)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 590.3 
               
               
                   
               
               
                 1011  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(1-(1- (pyridin-4-yl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl) amino)-4-(neopentylamino) quinoline-3,8-dicarbonitrile 
                 57 
                 588.3 
               
               
                   
               
               
                 1012  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3-cyano-2- methylphenyl)(1-(1- (difluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4-yl) methyl)amino)-4- (neopentylamino)quinoline- 3-carbonitrile 
                 4 
                 575.3 
               
               
                   
               
               
                 1013  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-cyano-2- methylphenyl)(1-(1- (difluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4-yl) methyl)amino)-4- (neopentylamino)quinoline- 3,8-dicarbonitrile 
                 57  
                 566.3 
               
               
                   
               
               
                 1014  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-1-(4-((2-chlorophenyl) ((3,8-dicyano-4- (neopentylamino)quinolin-6- yl)amino)methyl)-1H-1,2,3- triazol-1-yl)cyclobutane- 1-carboxamide 
                 57 
                 568.3 
               
               
                   
               
               
                 1015  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(1- cyclopropyl-1H-1,2,3-triazol-4- yl)methyl)amino)-8-fluoro-4- (neopentylamino)quinoline-3- carbonitrile 
                 1 
                 504.30 
               
               
                   
               
               
                 1016  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)- 4-((2-methyl-2-(pyridin-2- yl)propyl)amino)quinoline-3- carbonitrile 
                 1 
                 568.39 
               
               
                   
               
               
                 1017  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(1-(1- (trifluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4- yl)methyl)amino)-8-fluoro-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 572.2 
               
               
                   
               
               
                 1018  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-((2,2- dimethylcyclopentyl)amino)-6- (((S)-(4-fluorophenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl- d)amino)quinoline-3,8- dicarbonitrile 
                 9 
                 590.37 
               
               
                   
               
               
                 1019  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-((3-cyano-2,2- dimethylpropyl)amino)-6-(((4- fluorophenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl- d)amino)quinoline-3,8- dicarbonitrile 
                 57 
                 589.30 
               
               
                   
               
               
                 1020  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-1-(4-((2-chlorophenyl) ((3,8-dicyano-4- (neopentylamino)quinolin-6- yl)amino)methyl)-1H-1,2,3- triazol-1-yl)cyclopentane- 1-carboxamide 
                 57 
                 582.3 
               
               
                   
               
               
                 1021  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-2-(4-((2-chlorophenyl) ((3,8-dicyano-4- (neopentylamino)quinolin-6- yl)amino)methyl)-1H-1,2,3- triazol-1-yl)-2- methylpropanamide 
                 57 
                 556.3 
               
               
                   
               
               
                 1022  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3-(4-((S)-(2-chlorophenyl) ((3,8-dicyano-4- (neopentylamino)quinolin-6- yl)amino)methyl)-1H-1,2,3- triazol-1-yl)tetrahydrofuran-3- carboxamide 
                 57 
                 584.3 
               
               
                   
               
               
                 1023  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-(4-((2-chlorophenyl) ((3,8-dicyano-4- (neopentylamino)quinolin-6- yl)amino)methyl)-1H-1,2,3- triazol-1-yl)tetrahydro-2H- pyran-4-carboxamide 
                 57 
                 598.3 
               
               
                   
               
               
                 1024  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-cyanocyclopropyl)- 1H-1,2,3-triazol-4-yl)(o- tolyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 57 
                 516.3 
               
               
                   
               
               
                 1025  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-cyanocyclopropyl)- 1H-1,2,3-triazol-4-yl)(2- (difluoromethyl)phenyl)methyl) amino)-4- (neopentylamino)quinoline- 3,8-dicarbonitrile 
                 57 
                 552.2 
               
               
                   
               
               
                 1026  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1-cyanocyclopropyl)- 1H-1,2,3-triazol-4-yl)(2- (hydroxymethyl)phenyl)methyl) amino)-4- (neopentylamino)quinoline- 3,8-dicarbonitrile 
                 17 
                 532.2 
               
               
                   
               
               
                 1027  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chloro-3- cyanophenyl)(1-(1- cyanocyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 57 
                 562.2 
               
               
                   
               
               
                 1028  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- (((R)-1- phenylpropyl)amino)quinoline-3- carbonitrile 
                 2 
                 603.30 
               
               
                   
               
               
                 1029  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(tert-butyl)-1H-1,2,3- triazol-4-yl)(2- chlorophenyl)methyl-d)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 9 
                 528.3 
               
               
                   
               
               
                 1030  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((2-chlorophenyl)(1-(1- cyanocyclopropyl)-1H-1,2,3- triazol-4-yl)methyl-d)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 57 
                 537.1 
               
               
                   
               
               
                 1031  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-(1H-1,2,4-triazol-1- yl)phenyl)(1-cyclopropyl-1H- 1,2,3-triazol-4-yl)methyl) amino)-8-chloro-4- (neopentylamino)quinoline-3- carbonitrile 
                 3 
                 553.3 
               
               
                   
               
               
                 1032  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-(1H-imidazol-1- yl)phenyl)(1-cyclopropyl-1H- 1,2,3-triazol-4-yl) methyl)amino)-8-chloro-4- (neopentylamino)quinoline-3- carbonitrile 
                 3 
                 552.1 
               
               
                   
               
               
                 1033  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-(1H-pyrazol-1- yl)phenyl)(1-cyclopropyl-1H- 1,2,3-triazol-4-yl) methyl)amino)-8-chloro-4- (neopentylamino)quinoline-3- carbonitrile 
                 3 
                 552.1 
               
               
                   
               
               
                 1034  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d) amino)-4-((2,2- dimethylcyclopentyl)amino) quinoline-3,8-dicarbonitrile 
                 48 
                 522.32 
               
               
                   
               
               
                 1035 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(1-(1- methylcyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- ((3-hydroxy-2,2- dimethylpropyl)amino)quinoline- 3,8-dicarbonitrile 
                 57 
                 541.1 
               
               
                   
               
               
                 1036  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(1-(1- (fluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline- 3,8-dicarbonitrile 
                 9 
                 543.3 
               
               
                   
               
               
                 1037  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(1-(1- methylcyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)-8-(pyrimidin- 5-yl)quinoline-3-carbonitrile 
                 12 
                 578.19 
               
               
                   
               
               
                 1038  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3-(1H- pyrazol-1-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazo1-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 634.4 
               
               
                   
               
               
                 1039  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3-(2H- 1,2,3-triazol-2-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 635.3 
               
               
                   
               
               
                 1040  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3-(1H- 1,2,4-triazol-1-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 635.4 
               
               
                   
               
               
                 1041  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-(1H-imidazol-1-yl)-2- methylphenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 8-chloro-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 634.2 
               
               
                   
               
               
                 1042  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-(1H-imidazol-1-yl)-2- methylphenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 625.2 
               
               
                   
               
               
                 1043  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(1H-1,2,4- triazol-1-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 626.2 
               
               
                   
               
               
                 1044  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(2H-1,2,3- triazol-2-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 626.2 
               
               
                   
               
               
                 1045  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(1H-pyrazol-1- yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 625.1 
               
               
                   
               
               
                 1046  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-chloro-6- fluorophenyl)(1-(1- methylcyclopropyl)-1H-1,2,3- triazol-4-yl-5-d)methyl-d)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 59 
                 554.32 
               
               
                   
               
               
                 1047  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-chloro-6- fluorophenyl)(1-(1- methylcyclopropyl)-1H-1,2,3- triazol-4-yl)methyl-d)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 1 
                 553.31 
               
               
                   
               
               
                 1048  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chloro-6- fluorophenyl)(1-(1- methylcyclopropyl)-1H-1,2,3- triazol-4-yl-5-d)methyl-d)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 545.33 
               
               
                   
               
               
                 1049  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3-(1H- 1,2,4-triazol-1- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 617.3 
               
               
                   
               
               
                 1050  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3- (oxazol-2-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 635.4 
               
               
                   
               
               
                 1051  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3- (oxazol-2- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 617.2 
               
               
                   
               
               
                 1052  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-bromo-6-(((2- chlorophenyl)(1-(2,6- difluorobenzyl)-1H-1,2,3-triazol- 4-yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 1 
                 650.20 
               
               
                   
               
               
                 1053  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(1-(2,6- difluorobenzyl)-1H-1,2,3-triazol- 4-yl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 9 
                 597.30 
               
               
                   
               
               
                 1054  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3- (1H-1,2,4-triazol-1- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 608.1 
               
               
                   
               
               
                 1055  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(oxazol-2- yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazo1-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 626.2 
               
               
                   
               
               
                 1056  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3- (oxazol-2- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 608.2 
               
               
                   
               
               
                 1057  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3-(1H- tetrazol-1-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 636.2 
               
               
                   
               
               
                 1058  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazo1-4- yl)(phenyl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 536.3 
               
               
                   
               
               
                 1059  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-(neopentylamino)- 6-((phenyl(1-(1- (trifluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 4 
                 554.4 
               
               
                   
               
               
                 1060  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(o- tolyl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 550.3 
               
               
                   
               
               
                 1061  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-4-(neopentylamino)- 6-((o-tolyl(1-(1- (trifluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4- yl)methyl)amino)quinoline-3- carbonitrile 
                 4 
                 568.3 
               
               
                   
               
               
                 1062  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3- (1H-tetrazol-1 yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 618.6 
               
               
                   
               
               
                 1063  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3-(1H- 1,2,3-triazol-1-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 635.4 
               
               
                   
               
               
                 1064  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4- yl)(phenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 527.3 
               
               
                   
               
               
                 1065  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-(neopentylamino)-6- ((phenyl(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3,8- dicarbonitrile 
                 48 
                 545.3 
               
               
                   
               
               
                 1066  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(o- tolyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 541.3 
               
               
                   
               
               
                 1067  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-4-(neopentylamino)-6-((o- tolyl(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4- yl)methyl)amino)quinoline-3,8- dicarbonitrile 
                 48 
                 559.3 
               
               
                   
               
               
                 1068  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(1H-1,2,3- triazol-1-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 626.5 
               
               
                   
               
               
                 1069  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-(1H-imidazol-1-yl)-2- methylphenyl)(1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 8-chloro-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 616.4 
               
               
                   
               
               
                 1070  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3- (4H-1,2,4-triazol-4- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 617.3 
               
               
                   
               
               
                 1071  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3-(4H- 1,2,4-triazol-4-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 635.7 
               
               
                   
               
               
                 1072  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(4H-1,2,4- triazol-4-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 626.5 
               
               
                   
               
               
                 1073  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3-(4H- 1,2,4-triazol-4- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 608.3 
               
               
                   
               
               
                 1074  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-chloro-3- cyanophenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 614.2 
               
               
                   
               
               
                 1075  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-chloro-3- cyanophenyl)(1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 596.6 
               
               
                   
               
               
                 1076  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(4-fluoro-2- methylphenyl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 568.7 
               
               
                   
               
               
                 1077  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-(1H-imidazol-1-yl)-2- methylphenyl)(1-(1- (difluoromethypcyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 607.3 
               
               
                   
               
               
                 1078  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(2,6-difluorobenzyl)-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl-d)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 9 
                 582.3 
               
               
                   
               
               
                 1079  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chloro-3- cyanophenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 605.2 
               
               
                   
               
               
                 1080  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chloro-3- cyanophenyl)(1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 587.2 
               
               
                   
               
               
                 1081  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(1H-tetrazol-1- yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 57 
                 627.1 
               
               
                   
               
               
                 1082  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3-(1H- tetrazol-1- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 57 
                 609.3 
               
               
                   
               
               
                 1083  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(4-fluoro-2- methylphenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 559.3 
               
               
                   
               
               
                 1084  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4- cyanophenyl)(1-cyclopropyl-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 3 
                 511.3 
               
               
                   
               
               
                 1085  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3- (pyridin-4- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 3 
                 626 
               
               
                   
               
               
                 1086  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3-(1- methyl-1H-pyrazol-4- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 3 
                 629.10 
               
               
                   
               
               
                 1087  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 ethyl (S)-3-(((8-chloro-3-cyano-4- (neopentylamino)quinolin-6- yl)amino)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)-2- fluorobenzoate 
                 3 
                 644.13 
               
               
                   
               
               
                 1088  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 methyl (S)-5-(((8-chloro-3-cyano- 4-(neopentylamino)quinolin-6- yl)amino)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)-2- fluorobenzoate 
                 3 
                 630.05 
               
               
                   
               
               
                 1089  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3-cyano-2- methylphenyl)(1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-((3,3,3-trifluoro-2,2- dimethylpropyl)amino)quinoline- 3-carbonitrile 
                 4 
                 629.4 (M + H+) 
               
               
                   
               
               
                 1090  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3-fluoro-2- methylphenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 535.4 (M + H+) 
               
               
                   
               
               
                 1091  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3-(1- cyanocyclopropyl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 619.40 
               
               
                   
               
               
                 1092  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(bicyclo[1.1.1]pentan- 1-yl)-1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)-8- chloro-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 530.20 
               
               
                   
               
               
                 1093  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(bicyclo[1.1.1]pentan- 1-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-8- chloro-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 512.30 
               
               
                   
               
               
                 1094  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(bicyclo[1.1.1]pentan- 1-yl)-1H-1,2,3-triazol-4-yl)(3-(1- cyanocyclopropyl)phenyl)methyl) amino)-8-chloro-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 577.30 
               
               
                   
               
               
                 1095  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3 (pyridin-4-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 645.20 
               
               
                   
               
               
                 1096  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3- (pyridin-3-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 645.20 
               
               
                   
               
               
                 1097  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3-(1- methyl-1H-pyrazol-4-yl)phenyl) (1-(1-(trifluoromethyl) cyclopropyl)-1H-1,2,3-triazol- 4-yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 648.30 
               
               
                   
               
               
                 1098  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4-cyano-2- methylphenyl)(1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 575.40 
               
               
                   
               
               
                 1099  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((4-cyano-2- methylphenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 593.30 
               
               
                   
               
               
                 1100  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3-cyano-2- methylphenyl)(1-(1- (fluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 4 
                 557.30 
               
               
                   
               
               
                 1101  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3-cyano-2- methylphenyl)(1-(1- methylcyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 539.30 
               
               
                   
               
               
                 1102  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3-cyano-2- methylphenyl)(1-(1,3- difluoropropan-2-yl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 563.20 
               
               
                   
               
               
                 1103  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(3-cyano-2- methylphenyl)(1-((S)-1- fluoropropan-2-yl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 545.30 
               
               
                   
               
               
                 1104  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3-cyano-2- methylphenyl)(1-(1- methylcyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- ((3,3,3-trifluoro-2,2- dimethylpropyl)amino)quinoline- 3-carbonitrile 
                 4 
                 593.30 
               
               
                   
               
               
                 1105  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-([1,1&#39;-bi(cyclopropan)]- 1-yl)-1H-1,2,3-triazol-4-yl)(3- cyano-2- methylphenyl)methyl)amino)-8- chloro-4-((3,3,3-trifluoro-2,2- dimethylpropyl)amino)quinoline- 3-carbonitrile 
                 4 
                 619.40 
               
               
                   
               
               
                 1106  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8-chloro-6-(((S)-(3-cyano-2- methylphenyl)(1-((S)-1- fluoropropan-2-yl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- ((3,3,3-trifluoro-2,2- dimethylpropyl)amino) quinoline-3-carbonitrile 
                 4 
                 599.30 
               
               
                   
               
               
                 1107  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(bicyclo[1.1.1]pentan- 1-yl)-1H-1,2,3-triazol- 4-yl)(3-cyano-2-methylphenyl) methyl)amino)-8-chloro- 4-((3,3,3-trifluoro-2,2- dimethylpropyl)amino) quinoline-3-carbonitrile 
                 4 
                 605.30 
               
               
                   
               
               
                 1108  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(bicyclo[1.1.1] pentan-1-yl)-1H-1,2,3- triazol-4-yl)(3-cyano- 2-methylphenyl)methyl) amino)-8- chloro-4-(neopentylamino) quinoline-3-carbonitrile 
                 4 
                 551.40 
               
               
                   
               
               
                 1109  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-([1,1&#39;-bi(cyclopropan)]- 1-yl)-1H-1,2,3-triazol-4-yl)(3- cyano-2-methylphenyl)- methyl)amino)-8-chloro-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 565.40 
               
               
                   
               
               
                 1110  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2- chlorophenyl)(1-(1-(5-methyl- 1,3,4-oxadiazol-2-yl)cyclopropyl)- 1H-1,2,3-triazol-4- yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 4 
                 602.3 (M + H) 
               
               
                   
               
               
                 1111  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((2-chlorophenyl)(1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl-d) amino)-4-(neopentylamino)- quinoline-3,8-dicarbonitrile 
                 9 
                 562.30 
               
               
                   
               
               
                 1112  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-(((8-chloro-3-cyano-4- (neopentylamino)quinolin-6- yl)amino)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)-2- fluorobenzoic acid 
                 19 
                 616.16 
               
               
                   
               
               
                 1113  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-(((8-chloro-3-cyano-4- (neopentylamino)quinolin-6- yl)amino)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)-2- fluoro-N,N-dimethylbenzamide 
                 20 
                 643.23 
               
               
                   
               
               
                 1114  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-(((8-chloro-3-cyano-4- (neopentylamino)quinolin-6- yl)amino)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)-2- fluoro-N-methylbenzamide 
                 20 
                 629.26 
               
               
                   
               
               
                 1115  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-3-(((8-chloro-3-cyano-4- (neopentylamino)quinolin-6- yl)amino)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)-2- fluorobenzamide 
                 20 
                 615.34 
               
               
                   
               
               
                 1116  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-5-(((8-chloro-3-cyano-4- (neopentylamino)quinolin-6- yl)amino)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)-2- fluoro-N-methylbenzamide 
                 20 
                 629.19 
               
               
                   
               
               
                 1117  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-5-(((8-chloro-3-cyano-4- (neopentylamino)quinolin-6- yl)amino)(1-(1- (trifluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4-yl)methyl)- 2-fluorobenzamide 
                 20 
                 615.22 
               
               
                   
               
               
                 1118  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3- (pyridin-2-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 23 
                 645.10 
               
               
                   
               
               
                 1119  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3-(1- methyl-1H-imidazol-4- yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 23 
                 647.90 
               
               
                   
               
               
                 1120  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3-(1- methyl-1H-imidazol-5- yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 23 
                 648.30 
               
               
                   
               
               
                 1121  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3 (pyridazin-4-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3- carbonitrile 
                 23 
                 646.30 
               
               
                   
               
               
                 1122  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3-(1- methyl-1H-imidazol-5- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 23 
                 630.30 
               
               
                   
               
               
                 1123  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3- (pyridazin-4- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 23 
                 628.30 
               
               
                   
               
               
                 1124  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(bicyclo[1.1.1]pentan- 1-yl)-1H-1,2,3-triazol-4- yl)(phenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 24 
                 503.40 
               
               
                   
               
               
                 1125  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-cyano-2- methylphenyl)(1-(1- (difluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4-yl)methyl) amino)-4-((3,3,3-trifluoro-2,2- dimethylpropyl)amino)quinoline- 3,8-dicarbonitrile 
                 48 
                 620.2 (M + H+) 
               
               
                   
               
               
                 1126  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-cyano-2- methylphenyl)(1-(1- (difluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4-yl)methyl) amino)-4-((3,3,3-trifluoro-2,2- dimethylpropyl)amino)quinoline- 3,8-dicarbonitrile 
                 48 
                 620.15 (M + H+) 
               
               
                   
               
               
                 1127  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-fluoro-2- methylphenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 576.49 (M + H+) 
               
               
                   
               
               
                 1128  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-(1- cyanocyclopropyl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methy;)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 610.30 
               
               
                   
               
               
                 1129  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(bicyclo[1.1.1]pentan- 1-yl)-1H-1,2,3-triazol-4-yl)(3-(1- cyanocyclopropyl)phenyl)methyl) amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 568.40 
               
               
                   
               
               
                 1130  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(bicyclo[1.1.1]pentan- 1-yl)-1H-1,2,3-triazol-4-yl)(4- fluorophenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 521.40 
               
               
                   
               
               
                 1131  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(oxazol-5- yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 626.30 
               
               
                   
               
               
                 1132  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(1H-pyrazol- 3-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 625.30 
               
               
                   
               
               
                 1133  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(1H-pyrazol- 4-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 625.30 
               
               
                   
               
               
                 1134  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(pyridazin- 4-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 637.30 
               
               
                   
               
               
                 1135  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(1-methyl-1H- imidazol-5-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 639.30 
               
               
                   
               
               
                 1136  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(pyridin-3- yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 635.10 
               
               
                   
               
               
                 1137  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(pyridin-4- yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 635.10 
               
               
                   
               
               
                 1138  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(1-methyl- 1H-pyrazol-4-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 638 
               
               
                   
               
               
                 1139  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((4-cyano-2- methylphenyl)(1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 566.30 
               
               
                   
               
               
                 1140  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((4-cyano-2- methylphenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 584.30 
               
               
                   
               
               
                 1141  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3- (pyridin-4- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 617 
               
               
                   
               
               
                 1142  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3-(1- methyl-1H-pyrazol-4- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 620 
               
               
                   
               
               
                 1143  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(1-methyl- 1H-pyrazol-3-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 639.10 
               
               
                   
               
               
                 1144  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(pyridin-2- yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 636 
               
               
                   
               
               
                 1145  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-methyl-3-(1-methyl- 1H-imidazol-4-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl)amino)- 4-(neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 639 
               
               
                   
               
               
                 1146  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-cyano-2- methylphenyl)(1-(1- methylcyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- ((3,3,3-trifluoro-2,2- dimethylpropyl)amino)quinoline- 3,8-dicarbonitrile 
                 48 
                 584.20 
               
               
                   
               
               
                 1147  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-cyano-2- methylphenyl)(1-(1- (fluoromethyl)cyclopropyl)-1H- 1,2,3-triazo1-4-yl)methyl) amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 548.20 
               
               
                   
               
               
                 1148  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-cyano-2- methylphenyl)(1-(1- methylcyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 530.20 
               
               
                   
               
               
                 1149  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((3-cyano-2- methylphenyl)(1-(1,3- difluoropropan-2-yl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 554.30 
               
               
                   
               
               
                 1150  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 6-(((S)-(3-cyano-2- methylphenyl)(1-((S)-1- fluoropropan-2-yl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 536.30 
               
               
                   
               
               
                 1151  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(bicyclo[1.1.1]pentan- 1-yl)-1H-1,2,3-triazol- 4-yl)(3-cyano- 2-methylphenyl)methyl) amino)-4-((3,3,3-trifluoro-2,2- dimethylpropyl)amino) quinoline-3,8-dicarbonitrile 
                 48 
                 596.20 
               
               
                   
               
               
                 1152  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-([1,1&#39;-bi(cyclopropan)]- 1-yl)-1H-1,2,3-triazol-4-yl)(3- cyano-2- methylphenyl)methyl)amino)-4- ((3,3,3-trifluoro-2,2- dimethylpropyl)amino)quinoline- 3,8-dicarbonitrile 
                 48 
                 610.30 
               
               
                   
               
               
                 1153  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3- (1H-pyrazol-4- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 607.20 
               
               
                   
               
               
                 1154  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3-(1- methyl-1H-imidazol-5- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 621.20 
               
               
                   
               
               
                 1155  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3- (pyridazin-4- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 619.20 
               
               
                   
               
               
                 1156  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(bicyclo[1.1.1] pentan-1-yl)-1H-1,2,3- triazol-4-yl)(3-cyano- 2-methylphenyl)methyl)amino)- 4-(neopentylamino)quinoline- 3,8-dicarbonitrile 
                 48 
                 542.20 
               
               
                   
               
               
                 1157  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-([1,1&#39;-bi(cyclopropan)]- 1-yl)-1H-1,2,3-triazol-4-yl)(3- cyano-2- methylphenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 556.30 
               
               
                   
               
               
                 1158  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((1-(1- (difluoromethyl)cyclopropyl)-1H- 1,2,3-triazol-4-yl)(2-methyl-3- (oxazol-5- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 608.30 
               
               
                   
               
               
                 1159  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(5-fluoro- 1-(1-methylcyclopropyl)- 1H-1,2,3-triazol-4-yl) methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 543.10 
               
               
                   
               
               
                 1160  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(5- methoxy-1-(1- methylcyclopropyl)- 1H-1,2,3-triazol-4- yl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 555.20 
               
               
                   
               
               
                 1161  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-6-(((2-chlorophenyl)(1-(1- (5-methyl-1,3,4-oxadiazol-2- yl)cyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3,8- dicarbonitrile 
                 48 
                 593.30 
               
               
                   
               
               
                 1162  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3-(1- methyl-1H-pyrazol-3-yl)phenyl) (1-(1-(trifluoromethyl) cyclopropyl)- 1H-1,2,3-triazol-4- yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 62 
                 648.20 
               
               
                   
               
               
                 1163  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3- (1H-pyrazol-3-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4-yl) methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 62 
                 634.40 
               
               
                   
               
               
                 1164  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3- (1H-pyrazol-4-yl)phenyl) (1-(1-(trifluoromethyl) cyclopropyl)-1H- 1,2,3-triazol-4-yl)methyl) amino)-4-(neopentylamino) quinoline-3-carbonitrile 
                 62 
                 634.30 
               
               
                   
               
               
                 1165  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2-methyl-3 (oxazol-5-yl)phenyl)(1-(1- (trifluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4-yl) methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 62 
                 635.30 
               
               
                   
               
               
                 1166  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(1- (difluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4-yl) (2-methyl-3-(1H- pyrazol-4- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 62 
                 616.30 
               
               
                   
               
               
                 1167  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((1-(1- (difluoromethyl)cyclopropyl)- 1H-1,2,3-triazol-4-yl)(2- methyl-3-(oxazol-5- yl)phenyl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 62 
                 617.30 
               
               
                   
               
               
                 1168  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((3-cyano-2- methylphenyl)(1-(1- (difluoromethyl)cyclopropyl)-5- fluoro-1H-1,2,3-triazol-4- yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 60 
                 593.10 
               
               
                   
               
               
                 1169  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2- chlorophenyl)(5-fluoro-1-(1- methylcyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 60 
                 552.20 
               
               
                   
               
               
                 1170  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 (S)-8-chloro-6-(((2- chlorophenyl)(5-methoxy-1-(1- methylcyclopropyl)-1H-1,2,3- triazol-4-yl)methyl)amino)-4- (neopentylamino)quinoline-3- carbonitrile 
                 61 
                 564.20 
               
               
                   
               
            
           
         
       
     
     Proton NMR data for select compounds is shown below in Table 2. 
     
       
         
           
               
               
             
               
                 TABLE 2 
               
               
                   
               
               
                 Cmpd 
                 1H-NMR 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                 1 
                 1H NMR (400 MHz, DMSO-d6) δ 8.34 (d, J = 1.2 Hz, 1H), 8.01 (s, 1H), 7.72 (s, 1H), 
               
               
                   
                 7.59 (d, J = 2.2 Hz, 1H), 7.57-7.47 (m, 2H), 7.40 (s, 1H), 7.21-7.04 (m, 3H), 
               
               
                   
                 4.07-3.86 (m, 2H), 3.46 (dd, J = 13.9, 5.5 Hz, 1H), 1.23-1.00 (m, 4H), 0.88 (s, 9H) 
               
               
                 2 
                 1H NMR (400 MHz, DMSO-d6) δ 8.26 (s, 1H), 8.03 (s, 1H), 7.62-7.51 (m, 3H), 
               
               
                   
                 7.45-7.29 (m, 3H), 7.29-7.20 (m, 4H), 7.20-7.12 (m, 2H), 5.52-5.36 (m, 1H), 
               
               
                   
                 4.00-3.94 (m, 1H), 2.19-2.09 (m, 1H), 1.98-1.89 (m, 1H), 1.19-1.12 (m, 2H), 
               
               
                   
                 1.13-1.06 (m, 2H), 0.99-0.88 (m, 3H). 
               
               
                 4 
                 1H NMR (400 MHz, Methanol-d4) δ 8.52 (s, 1H), 7.83 (s, 1H), 7.63 (t, J = 1.5 Hz, 
               
               
                   
                 1H), 7.50 (d, J = 7.3 Hz, 2H), 7.40-7.30 (m, 2H), 7.02 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 5.25-5.12 (m, 2H), 4.11 (d, J = 13.8 Hz, 1H), 3.84 (d, J = 13.8 Hz, 1H), 1.00 (s, 9H). 
               
               
                 5 
                 1H NMR (400 MHz, DMSO-d6) δ 9.39 (s, 1H), 8.40 (s, 1H), 7.99 (s, 1H), 7.66 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.49-7.43 (m, 4H), 7.41 (t, J = 9.0 Hz, 2H), 7.36 (s, 1H), 7.25-7.18 (m, 
               
               
                   
                 3H), 7.18-7.11 (m, 2H), 6.06 (d, J = 7.4 Hz, 1H), 4.72 (ddd, J = 11.8, 7.7, 4.1 Hz, 
               
               
                   
                 1H), 3.60 (d, J = 12.3 Hz, 2H), 3.29-2.97 (m, 5H), 2.41-2.30 (m, 3H), 
               
               
                   
                 2.26-2.09 (m, 2H), 1.22 (t, J = 7.3 Hz, 3H). 
               
               
                 6 
                 1H NMR (400 MHz, DMSO-d6) δ 9.40 (m, 2H), 8.40 (s, 1H), 8.06 (s, 1H) 7.66 (m, 
               
               
                   
                 1H), 7.44-7.14 (m, 6H), 7.22 (m, 2H), 6.07 (m, 1H), 4.73 (m, 1H), 3.61 (m 2H), 
               
               
                   
                 3.21-3.05 (m, 4H), 2.32 (m, 2H), 2.17 (m, 2H), 1.21 (m, 3H). 
               
               
                 7 
                 1H NMR (400 MHz, DMSO-d6) δ 9.44 (s, 1H), 8.89 (dd, J = 1.7, 0.5 Hz, 1H), 8.42 (s, 
               
               
                   
                 1H), 7.69 (d, J = 2.3 Hz, 1H), 7.58-7.41 (m, 5H), 7.34 (d, J = 2.4 Hz, 1H), 7.27 (ddd, 
               
               
                   
                 J = 8.9, 4.2, 2.7 Hz, 1H), 7.25-7.17 (m, 2H), 6.62 (d, J = 1.7 Hz, 1H), 6.21 (d, J = 9.4 Hz, 
               
               
                   
                 1H). 
               
               
                 8 
                 1H NMR (400 MHz, DMSO-d6) δ 9.85 (s, 1H), 9.42 (s, 1H), 8.38 (s, 1H), 
               
               
                   
                 7.88-7.81 (m, 2H), 7.57-7.31 (m, 5H), 7.28-7.06 (m, 3H), 6.05 (s, 1H), 3.97 (s, 3H) 
               
               
                 10 
                 1H NMR (400 MHz, DMSO-d6) δ 9.61 (s, 1H), 9.22 (m, 1H), 8.46 (s, 1H), 
               
               
                   
                 8.18-8.09 (m, 2H), 7.99 (s, 1H), 7.72 (d, J = 2.2 Hz, 1H), 7.53-7.42 (m, 3H), 7.38-7.19 (m, 
               
               
                   
                 4H), 6.12-6.04 (m, 1H), 4.87-4.73 (m, 1H), 3.65 (d, J = 11.7 Hz, 2H), 3.12 (dt, J = 13.1, 
               
               
                   
                 10.2 Hz, 2H), 2.43-2.17 (m, 4H), 1.36 (s, 9H) 
               
               
                 13 
                 1H NMR (400 MHz, DMSO-d6) δ 8.33 (s, 1H), 7.88 (d, J = 2.1 Hz, 1H), 7.73 (s, 1H), 
               
               
                   
                 7.58-7.50 (m, 2H), 7.39 (s, 1H), 7.15-7.07 (m, 3H), 4.03 (dd, J = 13.9, 8.1 Hz, 1H), 
               
               
                   
                 3.98-3.88 (m, 1H), 3.41 (dd, J = 13.9, 5.3 Hz, 1H), 2.26 (d, J = 0.5 Hz, 3H), 
               
               
                   
                 1.28-1.14 (m, 4H), 0.85 (s, 9H). 
               
               
                 17 
                 1H NMR (400 MHz, Methanol-d4) δ 8.44 (s, 1H), 7.78 (s, 1H), 7.65 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.47 (d, J = 4.8 Hz, 2H), 7.38-7.23 (m, 5H), 7.18 (d, J = 2.4 Hz, 1H), 6.02 (s, 
               
               
                   
                 1H), 4.89-4.71 (m, 1H), 4.58 (s, 2H), 3.79 (d, J = 12.8 Hz, 2H), 3.21 (t, J = 13.0 Hz, 
               
               
                   
                 2H), 2.42 (d, J = 25.2 Hz, 4H), 1.46 (s, 9H) 
               
               
                 18 
                 1H NMR (400 MHz, Methanol-d4) δ 8.45 (s, 1H), 8.00 (s, 1H), 7.67 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.65 (s, 1H), 7.56 (d, J = 7.8 Hz, 1H), 7.53-7.40 (m, 3H), 7.36-7.23 (m, 2H), 
               
               
                   
                 7.21 (d, J = 2.3 Hz, 1H), 6.09 (s, 1H), 4.80 (d, J = 5.1 Hz, 1H), 4.35-4.21 (m, 2H), 
               
               
                   
                 3.79 (d, J = 12.7 Hz, 2H), 3.28-3.16 (m, 2H), 2.80 (s, 6H), 2.45 (m, 4H), 1.46 (s, 9H) 
               
               
                 20 
                 1H NMR (400 MHz, Methanol-d4) δ 8.43 (s, 1H), 7.84 (s, 1H), 7.65 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.56 (d, J = 7.8 Hz, 1H), 7.51 (s, 1H), 7.46 (t, J = 7.7 Hz, 2H), 7.37 (d, J = 7.6 Hz, 
               
               
                   
                 1H), 7.32 (t, J = 8.8 Hz, 1H), 7.25 (d, J = 2.9 Hz, 1H), 7.15 (d, J = 2.4 Hz, 1H), 6.07 (s, 
               
               
                   
                 1H), 4.82-4.72 (m, 1H), 3.81 (d, J = 13.0 Hz, 2H), 3.21 (d, J = 12.3 Hz, 2H), 3.06 (s, 
               
               
                   
                 3H), 2.88 (s, 3H), 2.54-2.32 (m, 4H), 1.46 (s, 9H) 
               
               
                 22 
                 1H NMR (400 MHz, Methanol-d4) δ 8.47 (s, 1H), 7.81 (d, J = 3.4 Hz, 1H), 7.68 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.53 (dd, J = 11.1, 4.7 Hz, 2H), 7.41-7.24 (m, 6H), 6.06 (s, 1H), 
               
               
                   
                 4.80 (m, 2H), 3.79 (d, J = 12.6 Hz, 2H), 3.23 (d, J = 12.6 Hz, 2H), 2.43 (m, 4H), 1.46 (s, 
               
               
                   
                 9H), 1.37 (d, J = 6.4 Hz, 3H) 
               
               
                 26 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) δ 8.55 (s, 1H), 8.40 (s, 1H), 7.64 (s, 
               
               
                   
                 1H), 7.52 (t, J = 7.9 Hz, 2H), 7.39 (d, J = 5.7 Hz, 2H), 7.11 (s, 1H), 4.36 (dd, J = 13.0, 
               
               
                   
                 10.4 Hz, 2H), 3.81 (d, J = 13.9 Hz, 1H), 3.66 (d, J = 13.8 Hz, 1H), 0.90 (s, 9H). 
               
               
                 27 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) δ 8.97 (s, 1H), 8.42 (s, 1H), 7.64 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.47-7.42 (m, 4H), 7.42-7.36 (m, 4H), 7.36-7.30 (m, 2H), 7.19 (qd, 
               
               
                   
                 J = 4.1, 2.8 Hz, 3H), 5.96 (s, 1H), 4.51-4.38 (m, 1H), 3.58 (d, J = 13.0 Hz, 4H), 
               
               
                   
                 3.25 (d, J = 12.2 Hz, 1H), 3.12 (q, J = 7.3 Hz, 2H), 3.06-2.93 (m, 2H), 2.35-2.25 (m, 3H), 
               
               
                   
                 2.05-1.91 (m, 2H), 1.20 (t, J = 7.3 Hz, 3H). 
               
               
                 32 
                 1H NMR (400 MHz, Methanol-d4) δ 8.41 (s, 1H), 7.83 (m, 1H), 7.65 (m, 1H), 
               
               
                   
                 7.54-7.18 (m, 8H), 7.16-7.03 (m, 2H), 6.17-6.05 (m, 2H), 4.93-4.76 (m, 2H), 
               
               
                   
                 4.67-4.58 (m, 1H), 4.51 (m, 1H), 3.93-3.82 (m, 1H), 1.26-1.09 (m, 4H). 
               
               
                 33 
                 1H NMR (400 MHz, Methanol-d4) δ 9.11 (s, 1H), 7.84 (s, 1H), 7.70 (m, 2H), 7.56 (m, 
               
               
                   
                 2H), 7.10 (m, 2H), 4.96-4.86 (m, 1H), 3.93-3.82 (m, 1H), 1.46 (s, 9H), 
               
               
                   
                 1.25-1.09 (m, 4H). 
               
               
                 37 
                 1H NMR (400 MHz, DMSO-d6) δ 8.25 (d, J = 5.6 Hz, 1H), 8.00 (d, J = 1.7 Hz, 1H), 
               
               
                   
                 7.86 (t, J = 7.3 Hz, 2H), 7.64 (t, J = 7.8 Hz, 1H), 7.56 (d, J = 2.2 Hz, 1H), 7.46 (s, 1H), 
               
               
                   
                 7.33 (d, J = 4.4 Hz, 1H), 7.30 (s, 1H), 7.27 (t, J = 4.3 Hz, 1H), 7.21 (d, J = 6.8 Hz, 4H), 
               
               
                   
                 7.10 (dd, J = 7.3, 2.1 Hz, 2H), 5.41 (q, J = 7.3 Hz, 1H), 3.78 (tt, J = 7.3, 3.8 Hz, 1H), 
               
               
                   
                 2.10 (dt, J = 14.1, 7.2 Hz, 1H), 1.91 (ddt, J = 20.8, 13.9, 7.1 Hz, 1H), 1.38-1.29 (m, 
               
               
                   
                 1H), 1.19-1.11 (m, 1H), 1.11-0.99 (m, 2H), 0.89 (t, J = 7.3 Hz, 3H), 0.81 (t, J = 7.2 Hz, 
               
               
                   
                 1H). 
               
               
                 38 
                 1H NMR (400 MHz, Methanol-d4) δ 8.43 (s, 1H), 7.78 (s, 1H), 7.65 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.45 (s, 2H), 7.40-7.20 (m, 5H), 7.16 (d, J = 1.7 Hz, 1H), 6.02 (s, 1H), 4.77 (s, 
               
               
                   
                 1H), 4.42 (s, 2H), 3.79 (d, J = 12.3 Hz, 2H), 3.32 (s, 3H), 3.23 (d, J = 12.3 Hz, 2H), 
               
               
                   
                 2.57-2.29 (m, 4H), 1.46 (s, 9H) 
               
               
                 40 
                 1H NMR (400 MHz, Methanol-d4) δ 8.43 (s, 1H), 7.84 (s, 1H), 7.63 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.47 (s, 1H), 7.44 (dd, J = 6.4, 2.6 Hz, 1H), 7.42-7.28 (m, 5H), 7.27-7.21 (m, 
               
               
                   
                 1H), 7.15 (d, J = 2.4 Hz, 1H), 6.00 (d, J = 0.9 Hz, 1H), 4.80 (m, 1H), 4.58 (s, 2H), 
               
               
                   
                 3.74-3.67 (m, 2H), 3.33-3.28 (m, 2H), 2.84 (s, 6H), 1.53 (d, J = 6.7 Hz, 6H) 
               
               
                 41 
                 1H NMR (400 MHz, Methanol-d4) δ 8.43 (s, 1H), 7.85 (s, 1H), 7.64 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.56 (d, J = 8.0 Hz, 1H), 7.51 (s, 1H), 7.48-7.43 (m, 2H), 7.36 (d, J = 7.7 Hz, 
               
               
                   
                 1H), 7.32 (t, J = 8.8 Hz, 1H), 7.26-7.22 (m, 1H), 7.15 (d, J = 2.5 Hz, 1H), 6.07 (s, 
               
               
                   
                 1H), 4.86-4.75 (m, 1H), 3.75 (d, J = 13.6 Hz, 2H), 3.24 (q, J = 7.2 Hz, 2H), 
               
               
                   
                 3.20-3.10 (m, 2H), 3.05 (s, 3H), 2.88 (s, 3H), 2.46 (d, J = 14.2 Hz, 2H), 2.36 (t, J = 13.0 Hz, 
               
               
                   
                 2H), 1.37 (t, J = 7.4 Hz, 3H) 
               
               
                 43 
                 1H NMR (400 MHz, DMSO-d6) δ 8.35 (s, 1H), 7.97 (s, 1H), 7.49 (dd, J = 8.6, 5.6 Hz, 
               
               
                   
                 2H), 7.10 (t, J = 8.8 Hz, 2H), 6.91 (s, 1H), 6.70 (s, 1H), 6.05 (d, J = 7.6 Hz, 1H), 
               
               
                   
                 4.08 (s, 1H), 4.00-3.86 (m, 1H), 3.51 (s, 1H), 1.16-1.00 (m, 4H), 0.89 (s, 9H). 
               
               
                 45 
                 1H NMR (400 MHz, DMSO-d6) δ 9.70 (s, 1H), 8.49 (s, 1H), 8.05-7.89 (m, 3H), 
               
               
                   
                 7.73 (d, J = 2.2 Hz, 1H), 7.46 (td, J = 7.9, 1.9 Hz, 1H), 7.41-7.28 (m, 2H), 7.24-7.11 (m, 
               
               
                   
                 3H), 6.25 (s, 1H), 4.00 (s, 3H) 
               
               
                 46 
                 1H NMR (400 MHz, DMSO-d6) δ 8.30-8.18 (m, 2H), 8.00-7.94 (m, 1H), 
               
               
                   
                 7.63-7.53 (m, 3H), 7.44-7.12 (m, 10H), 5.52-5.31 (m, 1H), 4.84 (brs), 4.57-4.40 (m, 
               
               
                   
                 2H), 3.81-3.66 (m, 1H), 2.96 (t, J = 11.0 Hz, 1H), 2.74 (d, J = 11.4 Hz, 1H), 
               
               
                   
                 2.19-2.00 (m, 2H), 1.98-1.85 (m, 2H), 1.24 (s, 9H), 0.99-0.86 (m, 3H). 
               
               
                 47 
                 1H NMR (400 MHz, Methanol-d4) δ 8.45 (s, 1H), 8.21 (s, 1H), 7.89 (d, J = 1.7 Hz, 
               
               
                   
                 1H), 7.82 (d, J = 7.9 Hz, 1H), 7.73 (dd, J = 7.7, 1.4 Hz, 1H), 7.67 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.58 (t, J = 7.8 Hz, 1H), 7.42 (dd, J = 9.4, 2.4 Hz, 1H), 7.35 (td, J = 4.9, 4.1, 2.4 Hz, 
               
               
                   
                 3H), 7.33-7.27 (m, 2H), 5.98 (dd, J = 8.6, 5.9 Hz, 1H), 2.66 (t, J = 7.1 Hz, 2H), 
               
               
                   
                 2.54 (dt, J = 22.5, 7.5 Hz, 1H), 2.40 (tt, J = 13.5, 7.1 Hz, 1H), 2.05-1.96 (m, 2H), 1.95 (d, J = 3.7 Hz, 
               
               
                   
                 2H). 
               
               
                 48 
                 1H NMR (400 MHz, DMSO-d6) δ 8.38 (d, J = 14.5 Hz, 1H), 8.23 (s, 1H), 
               
               
                   
                 7.66-7.43 (m, 3H), 7.42-7.13 (m, 9H), 6.37 (d, J = 6.4 Hz, 1H), 5.77-5.58 (m, 1H), 
               
               
                   
                 2.69-2.55 (m, 2H), 2.46-2.35 (m, 1H), 2.27-2.03 (m, 1H). 
               
               
                 49 
                 1H NMR (400 MHz, Methanol-d4) δ 8.44 (s, 1H), 8.17 (s, 1H), 7.63 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.48 (ddd, J = 9.6, 7.1, 2.3 Hz, 2H), 7.42-7.25 (m, 8H), 7.18 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 6.56 (s, 1H), 5.75 (t, J = 7.2 Hz, 1H), 2.20 (dt, J = 14.4, 7.3 Hz, 1H), 2.09 (dt, J = 14.1, 
               
               
                   
                 7.3 Hz, 1H), 2.04-1.97 (m, 2H), 1.97-1.91 (m, 2H), 1.01 (t, J = 7.3 Hz, 3H). 
               
               
                 50 
                 1H NMR (400 MHz, Methanol-d4) δ 8.52 (s, 1H), 8.19 (s, 1H), 7.86 (d, J = 1.7 Hz, 
               
               
                   
                 1H), 7.80 (dt, J = 7.9, 1.3 Hz, 1H), 7.73-7.67 (m, 2H), 7.56 (t, J = 7.8 Hz, 1H), 
               
               
                   
                 7.08 (d, J = 2.4 Hz, 1H), 4.24 (d, J = 14.0 Hz, 1H), 3.72 (d, J = 14.0 Hz, 1H), 
               
               
                   
                 2.05-1.96 (m, 2H), 1.96-1.90 (m, 2H), 0.97 (s, 9H). 
               
               
                 65 
                 1H NMR (400 MHz, Methanol-d4) δ 8.47 (s, 1H), 8.02 (s, 1H), 7.63 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.56-7.44 (m, 2H), 7.43-7.26 (m, 6H), 6.57 (s, 1H), 5.99 (dd, J = 8.2, 6.0 Hz, 
               
               
                   
                 1H), 5.79 (tt, J = 7.8, 6.0 Hz, 1H), 5.15-5.04 (m, 2H), 5.01 (t, J = 6.5 Hz, 2H), 2.63 (t, 
               
               
                   
                 J = 7.0 Hz, 2H), 2.55 (dt, J = 14.8, 6.4 Hz, 1H), 2.40 (dq, J = 13.8, 6.8 Hz, 1H). 
               
               
                 66 
                 1H NMR (400 MHz, Methanol-d4) δ 8.46 (s, 1H), 7.97 (d, J = 3.3 Hz, 1H), 7.63 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.55-7.46 (m, 2H), 7.46-7.30 (m, 6H), 7.28 (d, J = 2.3 Hz, 1H), 6.58 (s, 
               
               
                   
                 1H), 5.98 (dd, J = 8.2, 6.0 Hz, 1H), 5.62 (s, 2H), 2.62 (t, J = 7.1 Hz, 2H), 
               
               
                   
                 2.59-2.47 (m, 1H), 2.40 (dq, J = 13.7, 6.9 Hz, 1H). 
               
               
                 70 
                 1H NMR (400 MHz, DMSO-d6) δ 8.32 (s, 1H), 8.08 (s, 1H), 7.55-7.49 (m, 2H), 
               
               
                   
                 7.45-7.37 (m, 1H), 7.28 (dd, J = 5.9, 3.5 Hz, 2H), 7.00 (d, J = 2.4 Hz, 1H), 3.82 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 3.50 (d, J = 14.3 Hz, 1H), 1.67 (q, J = 5.1 Hz, 2H), 1.46 (q, J = 5.2 Hz, 
               
               
                   
                 2H), 0.85 (s, 9H). 
               
               
                 71 
                 1H NMR (400 MHz, DMSO-d6) δ 8.20 (s, 1H), 7.89 (s, 1H), 7.69 (s, 1H), 7.60 (d, J = 2.1 Hz, 
               
               
                   
                 1H), 7.55 (dd, J = 5.9, 3.6 Hz, 1H), 7.52-7.42 (m, 2H), 7.39-7.28 (m, 5H), 
               
               
                   
                 7.23 (s, 4H), 6.55 (d, J = 8.1 Hz, 1H), 5.62 (d, J = 5.9 Hz, 1H), 5.05 (s, 2H), 
               
               
                   
                 2.69-2.54 (m, 2H), 2.36 (s, 1H), 2.21-2.11 (m, 1H). 
               
               
                 72 
                 1H NMR (400 MHz, DMSO-d6) δ 8.22 (s, 1H), 8.06 (s, 1H), 7.57 (d, J = 2.1 Hz, 1H), 
               
               
                   
                 7.53 (dt, J = 7.4, 3.6 Hz, 1H), 7.46 (td, J = 8.0, 6.9, 3.9 Hz, 1H), 7.33 (td, J = 6.3, 3.0 Hz, 
               
               
                   
                 3H), 7.23 (dd, J = 10.2, 2.7 Hz, 5H), 6.50 (d, J = 6.7 Hz, 1H), 5.63 (q, J = 7.7 Hz, 
               
               
                   
                 1H), 2.71-2.53 (m, 2H), 2.32 (ddt, J = 20.3, 13.7, 7.6 Hz, 1H), 2.17 (dq, J = 13.6, 7.1 Hz, 
               
               
                   
                 1H), 1.61 (d, J = 2.9 Hz, 3H), 1.26 (t, J = 3.5 Hz, 2H), 1.06-0.98 (m, 2H). 
               
               
                 73 
                 1H NMR (400 MHz, DMSO-d6) δ 8.39 (s, 1H), 8.22 (s, 1H), 7.57 (d, J = 2.1 Hz, 1H), 
               
               
                   
                 7.55-7.43 (m, 2H), 7.43-7.30 (m, 3H), 7.24 (dd, J = 12.3, 2.6 Hz, 5H), 6.54 (d, J = 7.8 Hz, 
               
               
                   
                 1H), 5.63 (q, J = 7.9 Hz, 1H), 2.69-2.56 (m, 1H), 2.38-2.24 (m, 1H), 2.17 (q, 
               
               
                   
                 J = 6.5 Hz, 1H), 2.10-1.99 (m, 2H), 1.99-1.86 (m, 2H). 
               
               
                 74 
                 1H NMR (400 MHz, Methanol-d4) δ 8.42 (s, 1H), 7.81 (s, 1H), 7.64 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.51-7.43 (m, 2H), 7.44-7.26 (m, 7H), 7.25 (d, J = 2.3 Hz, 1H), 5.96 (dd, J = 8.2, 
               
               
                   
                 6.1 Hz, 1H), 3.88 (m, 1H), 2.64 (m, 2H), 2.58-2.44 (m, 1H), 2.38 (m, 1H), 
               
               
                   
                 1.26-1.09 (m, 4H) 
               
               
                 84 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 7.79 (d, J = 2.5 Hz, 1H), 7.75 (s, 
               
               
                   
                 1H), 7.51-7.43 (m, 2H), 7.41-7.32 (m, 2H), 7.34-7.25 (m, 1H), 7.23 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 3.97 (d, J = 13.9 Hz, 1H), 3.86 (m, 1H), 3.66 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 1.24-1.08 (m, 4H), 0.94 (s, 9H) 
               
               
                 90 
                 1H NMR (400 MHz, Methanol-d4) δ 8.44 (d, J = 1.5 Hz, 1H), 7.85 (s, 1H), 7.61 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.47 (dt, J = 6.1, 2.8 Hz, 2H), 7.33 (dt, J = 7.8, 5.6 Hz, 2H), 6.97 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 5.13 (s, 1H), 4.68 (dd, J = 14.6, 5.7 Hz, 1H), 4.62-4.45 (m, 2H), 4.19 (dt, 
               
               
                   
                 J = 9.4, 6.1 Hz, 1H), 4.01 (d, J = 13.9 Hz, 1H), 3.81 (d, J = 13.8 Hz, 1H), 2.71 (m, 1H), 
               
               
                   
                 2.43-2.25 (m, 1H), 0.97 (d, J = 2.2 Hz, 9H). 
               
               
                 91 
                 1H NMR (400 MHz, Methanol-d4) δ 8.45 (d, J = 0.9 Hz, 1H), 8.16 (d, J = 0.9 Hz, 1H), 
               
               
                   
                 7.60 (dd, J = 2.4, 0.9 Hz, 1H), 7.47 (td, J = 8.4, 8.0, 2.0 Hz, 2H), 7.39-7.27 (m, 2H), 
               
               
                   
                 6.95 (d, J = 2.3 Hz, 1H), 4.01 (d, J = 13.7 Hz, 1H), 3.79 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 2.02-1.96 (m, 2H), 1.96-1.88 (m, 2H), 1.02-0.93 (m, 9H). 
               
               
                 92 
                 1H NMR (400 MHz, Methanol-d4) δ 8.52 (s, 1H), 7.89 (d, J = 5.5 Hz, 1H), 7.66 (s, 
               
               
                   
                 1H), 7.50 (d, J = 8.0 Hz, 2H), 7.35 (p, J = 7.3 Hz, 2H), 7.04 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 4.76 (dd, J = 14.0, 3.2 Hz, 1H), 4.64-4.52 (m, 1H), 4.47 (s, 1H), 4.11 (dd, J = 13.8, 8.3 Hz, 
               
               
                   
                 1H), 3.84 (dd, J = 13.9, 9.4 Hz, 1H), 1.02 (s, 9H). 
               
               
                 93 
                 1H NMR (400 MHz, Methanol-d4) δ 8.53 (s, 1H), 7.96 (s, 1H), 7.66 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.54-7.49 (m, 1H), 7.49-7.44 (m, 1H), 7.37 (td, J = 8.2, 6.1 Hz, 2H), 7.04 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 5.39-5.25 (m, 2H), 4.11 (d, J = 13.9 Hz, 1H), 3.83 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 1.00 (s, 9H). 
               
               
                 98 
                 1H NMR (400 MHz, Methanol-d4) δ 8.51 (s, 1H), 7.98 (s, 1H), 7.64 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.49 (t, J = 8.1 Hz, 2H), 7.41-7.30 (m, 2H), 6.99 (d, J = 2.2 Hz, 1H), 4.41 (dd, J = 8.5, 
               
               
                   
                 4.3 Hz, 1H), 4.07 (d, J = 13.8 Hz, 1H), 3.84 (d, J = 13.8 Hz, 1H), 2.72 (d, J = 8.1 Hz, 
               
               
                   
                 1H), 1.86 (d, J = 14.6 Hz, 1H), 1.68 (q, J = 7.3 Hz, 1H), 1.00 (s, 9H). 
               
               
                 99 
                 1H NMR (400 MHz, Methanol-d4) δ 8.52 (s, 1H), 7.99 (s, 1H), 7.65 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.51 (d, J = 7.6 Hz, 1H), 7.46 (m, J = 7.1 Hz, 1H), 7.40-7.30 (m, 2H), 7.02 (t, J = 2.4 Hz, 
               
               
                   
                 1H), 4.64 (d, J = 8.7 Hz, 1H), 4.07 (dd, J = 13.7, 2.7 Hz, 1H), 3.89-3.81 (m, 
               
               
                   
                 1H), 2.53 (ddd, J = 15.1, 9.8, 5.3 Hz, 1H), 2.39 (t, J = 10.3 Hz, 1H), 1.00 (s, 9H). 
               
               
                 100 
                 1H NMR (400 MHz, Methanol-d4) δ 8.52 (s, 1H), 7.93 (s, 1H), 7.64 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.53-7.45 (m, 2H), 7.43-7.29 (m, 2H), 7.00 (d, J = 2.3 Hz, 1H), 4.87 (d, J = 7.3 Hz, 
               
               
                   
                 1H), 4.68 (dd, J = 7.9, 5.2 Hz, 2H), 4.34 (s, 1H), 4.17 (d, J = 2.9 Hz, 1H), 4.10 (d, 
               
               
                   
                 J = 13.8 Hz, 1H), 3.82 (d, J = 13.8 Hz, 1H), 3.71 (s, 2H), 3.50-3.37 (m, 2H), 2.70 (s, 
               
               
                   
                 2H), 1.00 (s, 9H). 
               
               
                 103 
                 1H NMR (400 MHz, DMSO-d6) δ 8.33 (s, 1H), 7.96 (s, 1H), 7.58 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.47-7.39 (m, 2H), 7.36 (s, 1H), 7.33-7.26 (m, 2H), 7.04 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 4.99 (dd, J = 21.6, 1.8 Hz, 2H), 4.77 (dd, J = 8.2, 4.4 Hz, 1H), 4.74-4.69 (m, 1H), 4.60 (dd, 
               
               
                   
                 J = 20.4, 8.3 Hz, 2H), 3.82 (dd, J = 13.7, 7.3 Hz, 1H), 3.50 (dd, J = 13.8, 5.2 Hz, 1H), 
               
               
                   
                 0.86 (s, 9H). 
               
               
                 104 
                 1H NMR (400 MHz, DMSO-d6) δ 8.33 (s, 1H), 7.85 (s, 1H), 7.59 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.51-7.45 (m, 1H), 7.45-7.39 (m, 1H), 7.37 (s, 1H), 7.33-7.26 (m, 2H), 7.05 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 4.72-4.59 (m, 2H), 4.48 (dd, J = 6.5, 5.1 Hz, 2H), 4.39 (t, J = 7.0 Hz, 
               
               
                   
                 2H), 3.84 (dd, J = 13.6, 7.4 Hz, 1H), 3.50 (dd, J = 13.7, 5.4 Hz, 1H), 0.87 (s, 9H). 
               
               
                 105 
                 1H NMR (400 MHz, DMSO-d6) δ 8.31 (s, 1H), 8.02 (s, 1H), 7.58 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.51 (s, 1H), 7.44 (ddd, J = 9.4, 4.5, 2.8 Hz, 2H), 7.35 (s, 1H), 7.33-7.26 (m, 2H), 
               
               
                   
                 7.03 (d, J = 2.4 Hz, 1H), 5.02 (dq, J = 18.1, 6.2 Hz, 1H), 4.76 (d, J = 5.6 Hz, 1H), 
               
               
                   
                 4.64 (d, J = 5.6 Hz, 1H), 3.80 (dd, J = 13.7, 7.3 Hz, 1H), 3.51 (dd, J = 13.7, 5.4 Hz, 1H), 
               
               
                   
                 1.45 (dd, J = 7.0, 1.4 Hz, 3H), 0.86 (s, 9H). 
               
               
                 106 
                 1H NMR (400 MHz, DMSO-d6) δ 8.31 (d, J = 1.1 Hz, 2H), 7.57 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.55-7.47 (m, 1H), 7.44 (ddd, J = 6.0, 3.5, 1.6 Hz, 2H), 7.34-7.26 (m, 3H), 7.03 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 3.75 (dd, J = 13.7, 7.3 Hz, 1H), 3.56 (dd, J = 13.7, 5.8 Hz, 1H), 
               
               
                   
                 1.77-1.69 (m, 2H), 1.66 (d, J = 6.0 Hz, 2H), 0.85 (s, 9H). 
               
               
                 107 
                 1H NMR (400 MHz, DMSO-d6) δ 8.29 (s, 1H), 8.03 (s, 1H), 7.55 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.49-7.38 (m, 2H), 7.32-7.24 (m, 2H), 6.97 (d, J = 2.4 Hz, 1H), 3.75 (dd, J = 13.7, 
               
               
                   
                 7.3 Hz, 1H), 3.54 (dd, J = 13.7, 5.7 Hz, 1H), 1.59 (s, 3H), 1.23 (t, J = 3.6 Hz, 2H), 
               
               
                   
                 1.01 (dd, J = 4.1, 2.9 Hz, 2H), 0.85 (s, 9H). 
               
               
                 109 
                 1H NMR (400 MHz, DMSO-d6) δ 8.28 (s, 1H), 8.01 (s, 1H), 7.58-7.54 (m, 1H), 
               
               
                   
                 7.52-7.45 (m, 1H), 7.45-7.37 (m, 1H), 7.35-7.23 (m, 3H), 6.98 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 3.76 (dd, J = 13.9, 7.3 Hz, 1H), 3.52 (dd, J = 13.8, 5.6 Hz, 1H), 1.56 (s, 8H), 0.86 (s, 9H). 
               
               
                 115 
                 1H NMR (400 MHz, DMSO-d6) δ 8.23 (s, 1H), 7.92 (d, J = 4.5 Hz, 1H), 
               
               
                   
                 7.67-7.51 (m, 3H), 7.49-7.09 (m, 8H), 6.35 (s, 1H), 5.48 (d, J = 7.6 Hz, 1H), 5.24 (s, 2H), 
               
               
                   
                 2.13 (dt, J = 14.2, 7.2 Hz, 1H), 1.91 (dt, J = 14.0, 7.1 Hz, 1H), 0.94 (t, J = 7.3 Hz, 3H). 
               
               
                 116 
                 1H NMR (400 MHz, DMSO-d6) δ 9.55 (s, 1H), 8.44 (s, 1H), 7.95 (d, J = 31.1 Hz, 3H), 
               
               
                   
                 7.70 (d, J = 2.2 Hz, 1H), 7.47 (dd, J = 8.5, 5.4 Hz, 3H), 7.23 (s, 1H), 7.14 (t, J = 8.7 Hz, 
               
               
                   
                 2H), 6.11 (s, 1H), 5.22 (s, 2H). 
               
               
                 117 
                 1H NMR (400 MHz, DMSO-d6) δ 8.72 (s, 1H), 8.36 (d, J = 1.5 Hz, 1H), 8.00 (d, J = 11.2 Hz, 
               
               
                   
                 4H), 7.56-7.47 (m, 3H), 7.46-7.37 (m, 3H), 7.35-7.21 (m, 1H), 
               
               
                   
                 7.21-7.09 (m, 7H), 3.99-3.86 (m, 3H), 2.80 (s, 1H), 2.17-2.02 (m, 2H), 1.77-1.47 (m, 5H), 
               
               
                   
                 1.18-1.00 (m, 13H) 
               
               
                 118 
                 1H NMR (400 MHz, DMSO-d6) δ 8.29 (s, 1H), 8.14 (s, 1H), 7.56 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.44 (ddd, J = 9.5, 6.4, 4.0 Hz, 2H), 7.30 (dd, J = 5.9, 3.4 Hz, 3H), 6.99 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 5.80 (p, J = 6.8 Hz, 1H), 4.96 (td, J = 7.3, 2.6 Hz, 2H), 4.87 (q, J = 6.5 Hz, 2H), 
               
               
                   
                 3.74 (dd, J = 13.7, 7.3 Hz, 1H), 3.58-3.49 (m, 1H), 0.84 (s, 9H). 
               
               
                 119 
                 1H NMR (400 MHz, DMSO-d6) δ 8.28 (s, 1H), 8.08 (s, 1H), 7.56 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.44 (td, J = 6.3, 3.4 Hz, 2H), 7.34-7.28 (m, 3H), 7.01 (s, 1H), 5.74 (d, J = 1.3 Hz, 
               
               
                   
                 2H), 3.75 (m, 1H), 3.51 (dd, J = 13.6, 5.7 Hz, 1H), 0.84 (s, 9H). 
               
               
                 120 
                 1H NMR (400 MHz, DMSO-d6) δ 8.39 (s, 1H), 7.99 (s, 1H), 7.58 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.52-7.40 (m, 2H), 7.36 (s, 1H), 7.33-7.22 (m, 2H), 6.75 (s, 1H), 5.92 (s, 1H), 
               
               
                   
                 3.95 (tt, J = 7.9, 4.3 Hz, 1H), 2.40-2.32 (m, 1H), 1.23 (s, 3H), 1.19 (s, 3H), 1.12 (q, J = 3.3 Hz, 
               
               
                   
                 2H), 1.07 (dd, J = 7.7, 5.2 Hz, 2H), 0.84 (d, J = 6.7 Hz, 3H), 0.76 (d, J = 6.7 Hz, 
               
               
                   
                 3H). 
               
               
                 121 
                 1H NMR (400 MHz, DMSO-d6) δ 8.30 (s, 1H), 8.00 (s, 1H), 7.68 (s, 1H), 7.55 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.47-7.40 (m, 2H), 7.32-7.25 (m, 2H), 7.03 (d, J = 2.4 Hz, 1H), 3.94 (tt, 
               
               
                   
                 J = 7.5, 4.0 Hz, 1H), 3.84 (dd, J = 14.1, 7.0 Hz, 1H), 3.65 (dd, J = 14.1, 5.7 Hz, 1H), 
               
               
                   
                 1.97-1.86 (m, 2H), 1.82 (dt, J = 11.4, 8.6 Hz, 1H), 1.68-1.52 (m, 3H), 1.12 (dq, J = 4.1, 
               
               
                   
                 2.4 Hz, 2H), 1.10-1.03 (m, 5H). 
               
               
                 123 
                 1H NMR (400 MHz, DMSO-d6) δ 8.56 (s, 1H), 8.40 (s, 1H), 8.01 (s, 1H), 7.52 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.48-7.43 (m, 1H), 7.43-7.39 (m, 1H), 7.35-7.28 (m, 2H), 7.19 (d, J = 2.4 Hz, 
               
               
                   
                 2H), 3.95 (tt, J = 7.5, 4.0 Hz, 1H), 1.55 (s, 3H), 1.17-1.10 (m, 2H), 
               
               
                   
                 1.10-1.04 (m, 2H), 1.01 (dd, J = 7.0, 2.9 Hz, 2H), 0.89 (t, J = 2.9 Hz, 2H). 
               
               
                 124 
                 1H NMR (400 MHz, DMSO-d6) δ 8.38 (s, 1H), 8.20 (s, 1H), 8.00 (s, 1H), 7.52 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.49-7.41 (m, 2H), 7.34-7.26 (m, 2H), 7.17 (d, J = 2.5 Hz, 2H), 3.95 (tt, 
               
               
                   
                 J = 7.5, 3.7 Hz, 1H), 2.80 (s, 1H), 2.08 (ddd, J = 12.9, 7.9, 5.3 Hz, 2H), 1.81-1.63 (m, 
               
               
                   
                 2H), 1.63-1.49 (m, 3H), 1.15-1.09 (m, 2H), 1.09-0.99 (m, 2H). 
               
               
                 125 
                 1H NMR (400 MHz, Methanol-d4) δ 8.47 (s, 1H), 7.92-7.84 (m, 2H), 7.82-7.77 (m, 
               
               
                   
                 1H), 7.72 (dt, J = 7.8, 1.4 Hz, 1H), 7.68 (d, J = 2.3 Hz, 1H), 7.57 (t, J = 7.8 Hz, 1H), 
               
               
                   
                 7.42-7.28 (m, 5H), 6.00 (dd, J = 8.5, 5.9 Hz, 1H), 3.89 (m, 1H), 2.66 (t, J = 7.1 Hz, 
               
               
                   
                 2H), 2.54 (m, 1H), 2.40 (m, 1H), 1.35-1.10 (m, 4H) 
               
               
                 128 
                 1H NMR (400 MHz, DMSO-d6) δ 8.36 (d, J = 10.8 Hz, 2H), 7.99 (d, J = 7.6 Hz, 2H), 
               
               
                   
                 7.88-7.82 (m, 1H), 7.75 (d, J = 2.4 Hz, 1H), 7.56-7.19 (m, 11H), 7.11 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.83 (d, J = 10.2 Hz, 1H), 6.62 (d, J = 10.1 Hz, 1H), 4.34-3.87 (m, 8H), 
               
               
                   
                 3.47-3.30 (m, 4H), 3.05 (dd, J = 14.8, 11.5 Hz, 2H), 1.93-1.75 (m, 3H), 1.19-1.01 (m, 
               
               
                   
                 7H), 0.91 (d, J = 6.0 Hz, 6H), 0.62 (s, 3H), 0.41 (s, 3H) 
               
               
                 129 
                 1H NMR (400 MHz, DMSO-d6) δ 8.33 (d, J = 7.4 Hz, 2H), 7.81 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 7.54-7.38 (m, 4H), 7.37-7.27 (m, 3H), 3.73 (dd, J = 13.8, 7.3 Hz, 1H), 3.57 (dd, J = 13.8, 
               
               
                   
                 5.9 Hz, 1H), 1.79-1.62 (m, 4H), 0.85 (s, 9H) 
               
               
                 130 
                 1H NMR (400 MHz, DMSO-d6) δ 8.32 (d, J = 4.2 Hz, 2H), 7.83 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.59-7.46 (m, 4H), 7.41 (d, J = 2.5 Hz, 1H), 7.20-7.09 (m, 2H), 3.91 (dd, J = 14.0, 
               
               
                   
                 7.8 Hz, 1H), 3.51-3.43 (m, 1H), 1.79-1.63 (m, 4H), 0.88 (s, 9H) 
               
               
                 131 
                 1H NMR (400 MHz, DMSO-d6) δ 8.36 (d, J = 3.4 Hz, 1H), 8.26 (d, J = 8.8 Hz, 1H), 
               
               
                   
                 7.84 (d, J = 2.4 Hz, 1H), 7.65-7.42 (m, 5H), 7.41-7.17 (m, 7H), 5.50-5.27 (m, 1H), 
               
               
                   
                 2.15-1.81 (m, 2H), 1.81-1.64 (m, 4H), 0.91 (td, J = 7.3, 1.6 Hz, 3H) 
               
               
                 132 
                 1H NMR (400 MHz, DMSO-d6) δ 8.38-8.23 (m, 2H), 7.84 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 7.68-7.47 (m, 5H), 7.43-7.12 (m, 7H), 5.53-5.33 (m, 1H), 2.12 (dt, J = 13.5, 7.3 Hz, 1H), 
               
               
                   
                 2.04-1.85 (m, 1H), 1.81-1.64 (m, 4H), 1.05-0.86 (m, 3H) 
               
               
                 134 
                 1H NMR (400 MHz, DMSO-d6) δ 8.36 (s, 1H), 7.99 (s, 1H), 7.69 (d, J = 8.0 Hz, 1H), 
               
               
                   
                 7.60 (d, J = 2.1 Hz, 1H), 7.54-7.47 (m, 2H), 7.40 (s, 1H), 7.21-7.08 (m, 2H), 
               
               
                   
                 7.06 (d, J = 2.4 Hz, 1H), 4.03 (dd, J = 14.2, 7.8 Hz, 1H), 3.98-3.89 (m, 1H), 3.59 (dd, J = 14.2, 
               
               
                   
                 5.3 Hz, 1H), 1.18-1.03 (m, 4H), 0.98 (s, 3H), 0.93 (s, 3H) 
               
               
                 136 
                 1H NMR (400 MHz, Methanol-d4) δ 8.45 (s, 1H), 7.85 (s, 1H), 7.69-7.64 (m, 1H), 
               
               
                   
                 7.60 (m, 2H), 7.44-7.31 (m, 6H), 7.15 (d, J = 2.3 Hz, 1H), 5.94 (m, 1H), 
               
               
                   
                 3.95-3.80 (m, 1H), 2.62 (m, 2H), 2.60 (s, 3H), 2.56-2.35 (m, 2H), 1.27-1.05 (m, 4H) 
               
               
                 141 
                 1H NMR (400 MHz, DMSO-d6) δ 8.34 (d, J = 10.8 Hz, 1H), 7.98 (d, J = 11.2 Hz, 1H), 
               
               
                   
                 7.65-7.16 (m, 5H), 6.86 (dd, J = 34.5, 2.4 Hz, 1H), 4.24 (dtd, J = 33.9, 10.5, 4.5 Hz, 
               
               
                   
                 1H), 3.95 (ddq, J = 14.6, 11.3, 3.8 Hz, 1H), 3.58-2.78 (m, 3H), 2.09-1.47 (m, 2H), 
               
               
                   
                 1.36-0.21 (m, 9H) 
               
               
                 142 
                 1H NMR (400 MHz, DMSO-d6) δ 8.35 (s, 1H), 8.08 (s, 1H), 7.99 (s, 1H), 
               
               
                   
                 7.59-7.41 (m, 3H), 7.41-7.22 (m, 1H), 7.22-7.00 (m, 3H), 4.11 (dd, J = 14.0, 8.5 Hz, 2H), 
               
               
                   
                 4.02-3.86 (m, 1H), 3.68 (ddd, J = 14.5, 8.4, 2.9 Hz, 2H), 2.89-2.75 (m, 1H), 
               
               
                   
                 2.12-1.88 (m, 2H), 1.21-1.00 (m, 4H) 
               
               
                 145 
                 1H NMR (400 MHz, DMSO-d6) δ 8.36 (s, 1H), 7.97 (d, J = 0.5 Hz, 1H), 7.62 (dd, J = 2.3, 
               
               
                   
                 0.6 Hz, 1H), 7.52-7.44 (m, 2H), 7.41 (s, 1H), 7.10 (ddd, J = 9.0, 7.7, 1.3 Hz, 2H), 
               
               
                   
                 6.95 (d, J = 2.4 Hz, 1H), 6.83 (d, J = 10.1 Hz, 1H), 4.32 (td, J = 11.0, 4.4 Hz, 1H), 
               
               
                   
                 4.07-3.89 (m, 2H), 3.50-3.28 (m, 2H), 3.05 (d, J = 11.5 Hz, 1H), 1.98 (qd, J = 12.1, 4.7 Hz, 
               
               
                   
                 1H), 1.87-1.71 (m, 1H), 1.24-1.01 (m, 4H), 0.91 (s, 3H), 0.45 (s, 3H) 
               
               
                 151 
                 1H NMR (400 MHz, DMSO-d6) δ 8.00 (s, 1H), 7.65-7.48 (m, 3H), 7.45-7.30 (m, 
               
               
                   
                 2H), 7.15-7.06 (m, 3H), 4.03-3.89 (m, 2H), 3.44 (dd, J = 13.9, 5.4 Hz, 1H), 
               
               
                   
                 1.18-1.02 (m, 4H), 0.89 (s, 10H) 
               
               
                 152 
                 1H NMR (400 MHz, DMSO-d6) δ 8.32 (s, 1H), 8.01 (s, 1H), 7.80 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.50-7.35 (m, 4H), 7.35-7.26 (m, 3H), 4.01-3.90 (m, 1H), 3.73 (dd, J = 13.7, 7.3 Hz, 
               
               
                   
                 1H), 3.54 (dd, J = 13.7, 5.8 Hz, 1H), 1.19-1.03 (m, 4H), 0.85 (s, 9H) 
               
               
                 158 
                 1H NMR (400 MHz, Methanol-d4) δ 8.15 (s, 1H), 7.90 (s, 1H), 7.59-7.46 (m, 3H), 
               
               
                   
                 7.39-7.26 (m, 5H), 7.12 m, 2H), 7.03 (s, 1H), 6.36 (m, 1H), 3.98 (m, 1H), 
               
               
                   
                 3.92-3.74 (m, 2H), 2.87 (s, 3H), 1.40-1.06 (m, 4H). 
               
               
                 164 
                 1H NMR (400 MHz, DMSO-d6) δ 8.17-8.11 (m, 2H), 8.01 (td, J = 1.7, 0.8 Hz, 1H), 
               
               
                   
                 7.95-7.87 (m, 1H), 7.80 (ddt, J = 7.6, 1.6, 0.8 Hz, 1H), 7.60 (t, J = 7.8 Hz, 1H), 
               
               
                   
                 7.42 (s, 1H), 7.35-7.12 (m, 8H), 5.72-5.61 (m, 1H), 4.03-3.93 (m, 1H), 2.72-2.58 (m, 
               
               
                   
                 2H), 2.53-2.36 (m, 1H), 2.26-2.15 (m, 1H), 1.22-1.05 (m, 4H) 
               
               
                 165 
                 1H NMR (400 MHz, DMSO-d6) δ 8.14 (d, J = 7.0 Hz, 2H), 7.96 (t, J = 1.7 Hz, 1H), 
               
               
                   
                 7.93-7.82 (m, 1H), 7.75 (dt, J = 7.7, 1.4 Hz, 1H), 7.58 (t, J = 7.7 Hz, 1H), 
               
               
                   
                 7.46-7.18 (m, 7H), 7.14 (d, J = 2.3 Hz, 1H), 5.63-5.52 (m, 1H), 4.03-3.93 (m, 1H), 
               
               
                   
                 2.57-2.51 (m, 2H), 2.38-2.24 (m, 2H), 1.26-1.00 (m, 5H) 
               
               
                 172 
                 1H NMR (400 MHz, DMSO-d6) δ 8.59 (s, 1H), 8.47 (s, 1H), 8.01 (s, 1H), 
               
               
                   
                 7.64-7.44 (m, 3H), 7.17-7.04 (m, 3H), 6.80 (d, J = 2.0 Hz, 1H), 4.13 (dd, J = 14.0, 8.0 Hz, 1H), 
               
               
                   
                 4.00-3.87 (m, 4H), 3.56 (dd, J = 14.0, 5.8 Hz, 1H), 1.22-0.99 (m, 4H), 0.89 (s, 9H). 
               
               
                 179 
                 1H NMR (400 MHz, DMSO-d6) δ 9.27 (s, 1H), 8.36 (s, 1H), 8.04 (s, 1H), 
               
               
                   
                 7.70-7.45 (m, 3H), 7.35 (s, 1H), 7.32-6.97 (m, 3H), 4.07-3.85 (m, 1H), 3.03 (m, 4H), 1.89 (s, 
               
               
                   
                 4H), 1.35-0.94 (m, 4H) 
               
               
                 182 
                 1H NMR (400 MHz, DMSO-d6) δ 9.65 (s, 1H), 8.51 (s, 1H), 8.01 (s, 1H), 7.90 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.52-7.28 (m, 8H), 7.22-7.13 (m, 1H), 4.00-3.90 (m, 1H), 
               
               
                   
                 1.17-1.01 (m, 4H) 
               
               
                 183 
                 1H NMR (400 MHz, DMSO-d6) δ 9.51 (s, 1H), 8.53 (s, 1H), 8.01 (s, 1H), 7.67 (s, 
               
               
                   
                 1H), 7.49-7.25 (m, 6H), 7.12 (t, J = 8.6 Hz, 1H), 6.99 (s, 1H), 4.00-3.90 (m, 1H), 
               
               
                   
                 1.17-1.01 (m, 4H) 
               
               
                 184 
                 1H NMR (400 MHz, DMSO-d6) δ 8.32 (s, 1H), 7.59 (d, J = 2.2 Hz, 1H), 7.57 (s, 1H), 
               
               
                   
                 7.55-7.48 (m, 2H), 7.35 (s, 1H), 7.20 (t, J = 8.8 Hz, 2H), 7.11 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 4.03 (s, 3H), 3.82 (dd, J = 13.9, 7.3 Hz, 1H), 3.59-3.49 (m, 1H), 0.85 (s, 9H). 
               
               
                 192 
                 1H NMR (400 MHz, DMSO-d6) δ 8.36 (s, 1H), 8.01 (s, 1H), 7.63-7.58 (m, 1H), 
               
               
                   
                 7.56-7.47 (m, 2H), 7.41 (s, 1H), 7.18-7.10 (m, 2H), 7.06 (d, J = 2.4 Hz, 1H), 4.09 (dd, J = 14.0, 
               
               
                   
                 8.0 Hz, 1H), 4.00-3.91 (m, 1H), 3.62 (dd, J = 14.1, 5.1 Hz, 1H), 3.55 (d, J = 11.0 Hz, 
               
               
                   
                 1H), 3.48 (d, J = 11.0 Hz, 1H), 1.23-1.03 (m, 4H), 0.94 (s, 3H), 0.92 (s, 3H) 
               
               
                 197 
                 1H NMR (400 MHz, Methanol-d4) δ 8.48 (s, 1H), 7.83 (s, 1H), 7.66 (dd, J = 7.8, 1.3 Hz, 
               
               
                   
                 1H), 7.63 (d, J = 2.2 Hz, 1H), 7.62-7.58 (m, 1H), 7.34 (t, J = 7.9 Hz, 1H), 
               
               
                   
                 6.80 (d, J = 2.3 Hz, 1H), 4.09 (d, J = 13.9 Hz, 1H), 3.89 (m, 1H), 3.73 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 2.57 (s, 3H), 1.26-1.09 (m, 4H), 0.92 (s, 9H) 
               
               
                 202 
                 1H NMR (400 MHz, DMSO-d6) δ 8.33 (d, J = 4.8 Hz, 1H), 8.06 (d, J = 6.2 Hz, 1H), 
               
               
                   
                 7.90-7.82 (m, 2H), 7.68-7.53 (m, 4H), 7.49-7.23 (m, 5H), 7.22-7.10 (m, 2H), 
               
               
                   
                 6.03-5.88 (m, 1H), 4.02-3.91 (m, 1H), 3.42-3.22 (m, 2H), 1.22-1.03 (m, 4H). 
               
               
                   
                 555.3 (M + H+). 
               
               
                 208 
                 1H NMR (400 MHz, DMSO-d6) δ 8.29-8.22 (m, 1H), 7.94-7.89 (m, 1H), 7.84 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.62-7.49 (m, 4H), 7.41-7.30 (m, 1H), 7.31-7.12 (m, 5H), 5.47 (q, J = 7.6 Hz, 
               
               
                   
                 1H), 4.02 (s, 3H), 2.18-2.04 (m, 1H), 2.06-1.83 (m, 2H), 0.98-0.85 (m, 
               
               
                   
                 4H) 
               
               
                 209 
                 1H NMR (400 MHz, DMSO-d6) δ 8.30 (s, 1H), 7.90 (s, 1H), 7.82 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.57-7.47 (m, 2H), 7.39 (d, J = 2.5 Hz, 1H), 7.19-7.09 (m, 1H), 4.00 (s, 3H), 
               
               
                   
                 3.94 (dd, J = 14.0, 7.9 Hz, 1H), 3.42 (dd, J = 13.9, 5.5 Hz, 1H), 3.20-3.11 (m, 1H), 1.56 (t, 
               
               
                   
                 J = 8.5 Hz, 1H), 1.30 (q, J = 7.4 Hz, 1H), 0.93 (t, J = 7.3 Hz, 1H), 0.87 (s, 9H) 
               
               
                 210 
                 1H NMR (400 MHz, DMSO-d6) δ 8.30-8.23 (m, 1H), 8.03 (s, 1H), 7.83 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.65-7.40 (m, 5H), 7.39-7.16 (m, 6H), 6.54 (s, 2H), 5.43 (td, J = 7.8, 6.2 Hz, 
               
               
                   
                 1H), 3.98 (tt, J = 7.5, 4.0 Hz, 1H), 2.14-1.81 (m, 2H), 1.22-1.02 (m, 4H), 
               
               
                   
                 0.95-0.83 (m, 3H) 
               
               
                 211 
                 1H NMR (400 MHz, DMSO-d6) δ 8.32 (s, 1H), 8.02 (s, 1H), 7.80 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.51-7.37 (m, 4H), 7.35-7.25 (m, 3H), 6.37 (d, J = 5.6 Hz, 1H), 4.01-3.90 (m, 1H), 
               
               
                   
                 3.73 (dd, J = 13.7, 7.3 Hz, 1H), 3.53 (dd, J = 13.7, 5.8 Hz, 1H), 1.18-1.02 (m, 4H), 
               
               
                   
                 0.84 (s, 9H) 
               
               
                 223 
                 1H NMR (400 MHz, DMSO-d6) δ 8.35 (d, J = 1.0 Hz, 1H), 8.01 (s, 1H), 7.61 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.56-7.48 (m, 2H), 7.43 (s, 1H), 7.20-7.10 (m, 2H), 7.07 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 4.07-3.88 (m, 2H), 3.52-3.41 (m, 1H), 1.23 (q, J = 7.4 Hz, 2H), 
               
               
                   
                 1.19-1.03 (m, 4H), 0.90-0.70 (m, 9H) 
               
               
                 239 
                 1H NMR (400 MHz, Methanol-d4) δ 8.47 (s, 1H), 7.86 (s, 1H), 7.84-7.82 (m, 1H), 
               
               
                   
                 7.78 (ddd, J = 7.9, 1.8, 1.2 Hz, 1H), 7.68 (dt, J = 7.7, 1.4 Hz, 1H), 7.66 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.55 (td, J = 7.8, 0.6 Hz, 1H), 7.02 (d, J = 2.3 Hz, 1H), 3.94-3.83 (m, 1H), 
               
               
                   
                 1.25-1.10 (m, 4H), 0.96 (s, 9H) 
               
               
                 240 
                 1H NMR (400 MHz, DMSO-d6) δ 8.32 (s, 1H), 8.11 (s, 1H), 7.91 (t, J = 1.7 Hz, 1H), 
               
               
                   
                 7.87-7.78 (m, 2H), 7.73 (dt, J = 7.7, 1.4 Hz, 1H), 7.54 (q, J = 8.4, 7.8 Hz, 2H), 
               
               
                   
                 7.33 (d, J = 2.5 Hz, 1H), 5.61 (s, 1H), 4.08-3.90 (m, 2H), 3.34 (dd, J = 14.0, 5.1 Hz, 1H), 
               
               
                   
                 1.20-1.04 (m, 4H), 0.84 (s, 9H) 
               
               
                 243 
                 1H NMR (400 MHz, DMSO-d6) δ 8.27 (d, J = 5.4 Hz, 1H), 8.14 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 8.03-7.95 (m, 1H), 7.93-7.71 (m, 3H), 7.63-7.47 (m, 4H), 7.43-7.32 (m, 1H), 
               
               
                   
                 7.31-7.08 (m, 4H), 5.47 (q, J = 7.4 Hz, 1H), 4.03-3.92 (m, 1H), 2.19-2.05 (m, 1H), 
               
               
                   
                 2.03-1.83 (m, 1H), 1.25-1.05 (m, 4H), 0.98-0.82 (m, 3H) 
               
               
                 249 
                 1H NMR (400 MHz, DMSO-d6) δ 8.26 (s, 1H), 8.01 (s, 1H), 7.69-7.48 (m, 4H), 
               
               
                   
                 7.37 (d, J = 5.4 Hz, 0H), 7.32-7.04 (m, 8H), 5.68 (td, J = 8.7, 5.5 Hz, 1H), 4.13-3.86 (m, 
               
               
                   
                 1H), 2.79-2.54 (m, 2H), 2.41 (dtd, J = 14.2, 8.2, 5.9 Hz, 1H), 2.31-2.07 (m, 1H), 
               
               
                   
                 1.29-0.92 (m, 4H). 
               
               
                 252 
                 1H NMR (400 MHz, DMSO-d6) δ 8.27 (s, 1H), 8.19 (s, 1H), 8.02 (dd, J = 2.0, 1.4 Hz, 
               
               
                   
                 1H), 7.91 (ddd, J = 7.9, 1.8, 1.2 Hz, 1H), 7.79 (dt, J = 7.7, 1.4 Hz, 1H), 7.62 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.61-7.55 (m, 1H), 7.52 (d, J = 9.9 Hz, 2H), 7.28 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.22 (qd, J = 3.7, 2.0 Hz, 3H), 7.14 (dd, J = 7.4, 2.1 Hz, 2H), 5.51 (d, J = 7.6 Hz, 1H), 
               
               
                   
                 2.14 (s, 1H), 1.93 (d, J = 7.0 Hz, 1H), 1.60 (d, J = 1.4 Hz, 9H), 0.95 (t, J = 7.3 Hz, 3H) 
               
               
                 254 
                 1H NMR (400 MHz, DMSO-d6) δ 8.31 (d, J = 5.4 Hz, 1H), 8.15 (d, J = 5.6 Hz, 1H), 
               
               
                   
                 8.03-7.69 (m, 3H), 7.59 (q, J = 7.7 Hz, 2H), 7.45-7.16 (m, 8H), 5.69 (dtd, J = 31.7, 
               
               
                   
                 8.7, 5.5 Hz, 1H), 4.03-3.91 (m, 1H), 2.74-2.17 (m, 4H), 1.25-1.02 (m, 4H) 
               
               
                 255 
                 1H NMR (400 MHz, DMSO-d6) δ 8.29 (d, J = 1.7 Hz, 1H), 8.04 (d, J = 4.8 Hz, 1H), 
               
               
                   
                 7.88 (d, J = 8.8 Hz, 1H), 7.63-7.51 (m, 3H), 7.44-7.13 (m, 9H), 5.78-5.57 (m, 1H), 
               
               
                   
                 4.03-3.93 (m, 1H), 2.72-2.51 (m, 2H), 2.49-2.31 (m, 2H), 1.21-1.04 (m, 4H) 
               
               
                 256 
                 1H NMR (400 MHz, DMSO-d6) δ 8.43 (s, 1H), 8.11 (s, 1H), 8.01 (s, 1H), 7.92 (dd, J = 1.9, 
               
               
                   
                 1.4 Hz, 1H), 7.83 (ddd, J = 7.9, 1.8, 1.2 Hz, 1H), 7.73 (dt, J = 7.7, 1.4 Hz, 1H), 
               
               
                   
                 7.65 (s, 1H), 7.57-7.48 (m, 1H), 7.31 (dd, J = 12.6, 2.0 Hz, 1H), 6.96 (d, J = 2.1 Hz, 
               
               
                   
                 1H), 4.13 (dd, J = 14.0, 8.4 Hz, 1H), 4.01-3.90 (m, 1H), 3.40 (dd, J = 14.0, 5.2 Hz, 
               
               
                   
                 1H), 1.20-1.04 (m, 4H), 0.87 (s, 9H) 
               
               
                 257 
                 1H NMR (400 MHz, DMSO-d6) δ 8.37 (s, 1H), 8.13 (s, 1H), 7.99 (t, J = 1.7 Hz, 1H), 
               
               
                   
                 7.93-7.69 (m, 3H), 7.65-7.52 (m, 2H), 7.45-7.17 (m, 7H), 5.57 (q, J = 7.6 Hz, 1H), 
               
               
                   
                 4.02-3.92 (m, 1H), 2.25-1.89 (m, 2H), 1.22-1.05 (m, 4H), 1.00-0.84 (m, 3H) 
               
               
                 259 
                 1H NMR (400 MHz, Methanol-d4) δ 8.24 (s, 1H), 7.87-7.71 (m, 3H), 7.68-7.45 (m, 
               
               
                   
                 3H), 7.33-7.16 (m, 4H), 7.13-7.06 (m, 2H), 6.92 (m, 1H), 6.05 (m, 1H), 
               
               
                   
                 4.83-4.66 (m, 3H), 3.86-3.70 (m, 2H), 1.18-1.02 (m, 4H). 
               
               
                 263 
                 1H NMR (400 MHz, DMSO-d6) δ 8.33 (s, 1H), 7.53 (s, 1H), 7.49 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.46 (ddd, J = 9.0, 5.4, 1.9 Hz, 2H), 7.35 (s, 1H), 7.18-7.07 (m, 3H), 7.03-6.95 (m, 
               
               
                   
                 2H), 6.76-6.69 (m, 2H), 5.74-5.55 (m, 2H), 3.84 (dd, J = 13.9, 7.4 Hz, 1H), 3.65 (s, 
               
               
                   
                 3H), 3.56 (dd, J = 13.9, 5.9 Hz, 1H), 2.06 (s, 2H), 0.87 (s, 9H). 
               
               
                 264 
                 1H NMR (400 MHz, DMSO-d6) δ 9.65 (s, 1H), 8.49 (s, 1H), 8.10 (s, 1H), 
               
               
                   
                 8.06-7.95 (m, 2H), 7.88 (t, J = 1.8 Hz, 1H), 7.85-7.65 (m, 2H), 7.65-7.52 (m, 3H), 7.22 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 6.15 (s, 1H), 4.02-3.91 (m, 1H), 1.20-1.03 (m, 4H) 
               
               
                 265 
                 1H NMR (400 MHz, DMSO-d6) δ 9.60 (s, 1H), 8.48 (s, 1H), 8.08-7.95 (m, 3H), 
               
               
                   
                 7.70 (d, J = 2.3 Hz, 1H), 7.46 (d, J = 8.2 Hz, 1H), 7.42-7.17 (m, 5H), 7.07 (tdd, J = 8.1, 
               
               
                   
                 2.7, 1.0 Hz, 1H), 6.06 (s, 1H), 4.00-3.90 (m, 1H), 1.19-1.02 (m, 4H) 
               
               
                 266 
                 1H NMR (400 MHz, DMSO-d6) δ 9.61 (s, 1H), 8.48 (s, 1H), 8.10-7.96 (m, 3H), 
               
               
                   
                 7.70 (d, J = 2.2 Hz, 1H), 7.52 (t, J = 1.8 Hz, 1H), 7.48-7.26 (m, 3H), 7.20 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 6.06 (s, 1H), 4.01-3.90 (m, 1H), 1.20-1.02 (m, 5H) 
               
               
                 268 
                 1H NMR (400 MHz, DMSO-d6) δ 8.37 (d, J = 4.8 Hz, 1H), 8.11 (s, 1H), 8.02 (d, J = 0.7 Hz, 
               
               
                   
                 1H), 7.58 (t, J = 2.2 Hz, 1H), 7.55-7.46 (m, 2H), 7.38 (s, 1H), 7.22-7.09 (m, 
               
               
                   
                 3H), 4.02-3.92 (m, 1H), 3.92-3.71 (m, 2H), 1.77-1.44 (m, 3H), 1.22-1.03 (m, 
               
               
                   
                 5H), 0.94 (d, J = 6.3 Hz, 3H), 0.90 (d, J = 6.3 Hz, 3H) 
               
               
                 272 
                 1H NMR (400 MHz, DMSO-d6) δ 8.26 (s, 1H), 8.08 (s, 1H), 7.64-7.51 (m, 2H), 
               
               
                   
                 7.44-7.07 (m, 11H), 6.34 (s, 1H), 5.50 (q, J = 7.4 Hz, 1H), 4.03-3.92 (m, 1H), 
               
               
                   
                 2.22-2.05 (m, 1H), 1.98-1.84 (m, 1H), 1.21-1.04 (m, 4H), 0.95 (t, J = 7.3 Hz, 3H) 
               
               
                 273 
                 1H NMR (400 MHz, DMSO-d6) δ 30.78 (s, 1H), 30.59 (s, 1H), 30.15-29.93 (m, 5H), 
               
               
                   
                 29.93-29.63 (m, 8H), 28.83 (s, 1H), 28.00 (q, J = 7.5 Hz, 1H), 26.53-26.43 (m, 1H), 
               
               
                   
                 24.73-24.57 (m, 1H), 24.54-24.35 (m, 1H), 23.72-23.54 (m, 4H), 23.45 (t, J = 7.2 Hz, 
               
               
                   
                 3H) 
               
               
                 284 
                 1H NMR (400 MHz, DMSO-d6) δ 8.31 (s, 1H), 8.02 (s, 1H), 7.81 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.59-7.44 (m, 4H), 7.37 (d, J = 2.5 Hz, 1H), 7.19-7.08 (m, 2H), 4.00-3.88 (m, 2H), 
               
               
                   
                 3.43 (dd, J = 13.9, 5.5 Hz, 1H), 1.18-1.03 (m, 4H), 0.86 (s, 9H) 
               
               
                 285 
                 1H NMR (400 MHz, DMSO-d6) δ 8.27 (s, 1H), 8.03 (s, 1H), 7.83 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.61-7.46 (m, 5H), 7.30-7.11 (m, 7H), 5.47 (q, J = 7.6 Hz, 1H), 4.02-3.92 (m, 1H), 
               
               
                   
                 2.18-2.04 (m, 1H), 1.99-1.85 (m, 1H), 1.20-1.04 (m, 4H), 0.94 (t, J = 7.3 Hz, 3H) 
               
               
                 286 
                 1H NMR (400 MHz, DMSO-d6) δ 8.75 (s, 1H), 8.38-8.11 (m, 2H), 8.05 (d, J = 7.9 Hz, 
               
               
                   
                 1H), 7.77-7.52 (m, 4H), 7.52-7.02 (m, 7H), 6.04-5.81 (m, 1H), 3.97 (dq, J = 11.4, 
               
               
                   
                 3.8 Hz, 1H), 3.39-3.22 (m, 2H), 1.33-0.93 (m, 4H) 
               
               
                 287 
                 1H NMR (400 MHz, DMSO-d6) δ 8.31 (s, 1H), 8.01 (s, 1H), 7.78 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.71 (s, 1H), 7.57-7.46 (m, 2H), 7.38 (s, 1H), 7.18-7.07 (m, 3H), 4.04-3.89 (m, 
               
               
                   
                 2H), 3.46 (dd, J = 13.9, 5.5 Hz, 1H), 1.19-1.03 (m, 4H), 0.87 (s, 9H) 
               
               
                 288 
                 1H NMR (400 MHz, DMSO-d6) δ 8.24 (s, 1H), 8.02 (s, 1H), 7.78 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.63-7.51 (m, 2H), 7.48 (d, J = 9.0 Hz, 1H), 7.41-7.31 (m, 1H), 7.31-7.10 (m, 8H), 
               
               
                   
                 5.54-5.43 (m, 1H), 4.02-3.92 (m, 1H), 2.21-2.05 (m, 1H), 2.02-1.84 (m, 1H), 
               
               
                   
                 1.20-1.04 (m, 4H), 0.95 (t, J = 7.3 Hz, 3H).) 
               
               
                 289 
                 1H NMR (400 MHz, DMSO-d6) δ 8.31 (s, 1H), 8.09 (s, 1H), 7.90 (dd, J = 7.7, 1.6 Hz, 
               
               
                   
                 1H), 7.74 (dd, J = 8.0, 1.6 Hz, 1H), 7.58 (d, J = 2.2 Hz, 1H), 7.50 (t, J = 7.8 Hz, 1H), 
               
               
                   
                 7.43 (s, 1H), 6.82 (d, J = 2.4 Hz, 1H), 3.99-3.92 (m, 1H), 3.85 (dd, J = 13.7, 8.1 Hz, 
               
               
                   
                 1H), 3.36 (dd, J = 13.7, 4.9 Hz, 1H), 1.18-1.11 (m, 2H), 1.11-1.06 (m, 2H), 0.78 (s, 
               
               
                   
                 9H). 
               
               
                 290 
                 1H NMR (400 MHz, DMSO-d6) δ 8.88 (d, J = 6.4 Hz, 1H), 8.47 (s, 1H), 
               
               
                   
                 8.27-8.19 (m, 1H), 8.03 (s, 1H), 7.61 (s, 1H), 7.58-7.49 (m, 2H), 7.44-7.26 (m, 1H), 
               
               
                   
                 7.21-7.08 (m, 1H), 7.08-7.02 (m, 1H), 4.06 (dd, J = 14.0, 7.9 Hz, 1H), 4.00-3.89 (m, 1H), 
               
               
                   
                 3.58-3.48 (m, 1H), 1.18-1.03 (m, 4H), 0.90 (s, 9H) 
               
               
                 291 
                 1H NMR (400 MHz, DMSO-d6) δ 8.36 (s, 1H), 8.03 (s, 1H), 7.88 (d, J = 8.7 Hz, 1H), 
               
               
                   
                 7.55 (ddt, J = 7.3, 5.4, 2.6 Hz, 2H), 7.43-7.10 (m, 10H), 5.56 (q, J = 7.7 Hz, 1H), 
               
               
                   
                 4.01-3.91 (m, 1H), 2.23-2.07 (m, 1H), 2.07-1.89 (m, 1H), 1.20-1.04 (m, 4H), 
               
               
                   
                 0.99-0.86 (m, 3H) 
               
               
                 293 
                 1H NMR (400 MHz, DMSO-d6) δ 9.64 (s, 1H), 8.55 (s, 1H), 8.05 (s, 1H), 
               
               
                   
                 7.87-7.73 (m, 2H), 7.68 (d, J = 2.3 Hz, 1H), 7.62-7.48 (m, 2H), 7.44 (dd, J = 7.9, 1.6 Hz, 1H), 
               
               
                   
                 7.35 (t, J = 7.9 Hz, 1H), 6.88 (d, J = 2.4 Hz, 1H), 6.17 (d, J = 6.8 Hz, 1H), 
               
               
                   
                 4.00-3.90 (m, 1H), 1.20-1.02 (m, 4H) 
               
               
                 294 
                 1H NMR (400 MHz, DMSO-d6) δ 8.26 (d, J = 2.6 Hz, 1H), 8.07 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 7.65-7.44 (m, 5H), 7.42-7.14 (m, 7H), 6.60-6.49 (m, 1H), 5.44 (q, J = 7.4 Hz, 1H), 
               
               
                   
                 4.04-3.93 (m, 1H), 2.16-2.00 (m, 1H), 2.01-1.80 (m, 1H), 1.23-1.04 (m, 4H), 
               
               
                   
                 0.94-0.82 (m, 3H).) 
               
               
                 296 
                 1H NMR (400 MHz, Methanol-d4) δ 8.20 (s, 1H), 7.90 (s, 1H), 7.87 (t, J = 1.7 Hz, 
               
               
                   
                 1H), 7.82 (dt, J = 7.9, 1.4 Hz, 1H), 7.72-7.61 (m, 1H), 7.58-7.49 (m, 2H), 
               
               
                   
                 7.37-7.23 (m, 5H), 7.12 (d, J = 2.4 Hz, 1H), 6.04 (t, J = 6.9 Hz, 1H), 3.88 (m, 1H), 3.22 (d, J = 6.9 Hz, 
               
               
                   
                 2H), 1.24-1.11 (m, 4H) 
               
               
                 300 
                 1H NMR (400 MHz, DMSO-d6) δ 8.26 (s, 1H), 8.03 (s, 1H), 7.63-7.42 (m, 4H), 
               
               
                   
                 7.42-7.22 (m, 3H), 7.22-7.01 (m, 5H), 5.48 (q, J = 7.6 Hz, 1H), 4.07-3.87 (m, 1H), 
               
               
                   
                 2.12 (dt, J = 14.4, 7.4 Hz, 1H), 1.95 (dt, J = 13.8, 6.8 Hz, 1H), 1.24-1.01 (m, 4H), 
               
               
                   
                 0.94 (t, J = 7.2 Hz, 3H) 
               
               
                 305 
                 1H NMR (400 MHz, DMSO-d6) δ 8.27 (s, 1H), 8.02 (s, 1H), 7.73-7.56 (m, 4H), 
               
               
                   
                 7.45 (d, J = 8.3 Hz, 1H), 7.34-7.22 (m, 6H), 7.17 (t, J = 8.9 Hz, 1H), 6.25 (d, J = 8.2 Hz, 
               
               
                   
                 1H), 6.02-5.92 (m, 1H), 4.81 (p, J = 6.7 Hz, 1H), 3.34 (m, 2H), 1.49 (d, J = 2.3 Hz, 
               
               
                   
                 3H), 1.47 (d, J = 2.3 Hz, 3H) 
               
               
                 329 
                 1H NMR (400 MHz, DMSO-d6) δ 9.68 (s, 1H), 8.48 (s, 1H), 8.08-7.97 (m, 3H), 
               
               
                   
                 7.68 (d, J = 2.3 Hz, 1H), 7.59-7.42 (m, 4H), 7.27-7.09 (m, 5H), 5.64 (d, J = 1.2 Hz, 2H) 
               
               
                 330 
                 1H NMR (400 MHz, DMSO-d6) δ 9.63 (s, 1H), 8.49 (s, 1H), 8.08-7.97 (m, 3H), 
               
               
                   
                 7.71 (d, J = 2.3 Hz, 1H), 7.60-7.45 (m, 3H), 7.28 (d, J = 2.4 Hz, 1H), 7.26-7.13 (m, 2H), 
               
               
                   
                 6.43 (s, 1H), 6.30 (s, 1H) 
               
               
                 331 
                 1H NMR (400 MHz, DMSO-d6) δ 8.28 (s, 1H), 8.04 (s, 1H), 7.71 (d, J = 8.6 Hz, 1H), 
               
               
                   
                 7.66-7.53 (m, 3H), 7.53-7.38 (m, 2H), 7.38-7.23 (m, 6H), 7.23-7.07 (m, 3H), 
               
               
                   
                 5.98 (td, J = 8.3, 5.8 Hz, 1H), 4.09-3.82 (m, 1H), 3.50-3.25 (m, 2H), 1.29-1.01 (m, 
               
               
                   
                 6H) 
               
               
                 333 
                 1H NMR (400 MHz, DMSO-d6) δ 8.35 (s, 1H), 8.01 (s, 1H), 7.73 (s, 1H), 7.60 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.57-7.47 (m, 2H), 7.42 (s, 1H), 7.26-7.00 (m, 3H), 4.08 (dd, J = 14.1, 
               
               
                   
                 8.0 Hz, 1H), 4.01-3.90 (m, 1H), 3.74-3.57 (m, 2H), 3.57-3.41 (m, 3H), 1.45 (ddd, 
               
               
                   
                 J = 16.3, 10.4, 5.1 Hz, 2H), 1.27-1.02 (m, 6H), 0.94 (s, 3H) 
               
               
                 340 
                 1H NMR (400 MHz, Methanol-d4) δ 8.29 (s, 1H), 7.78 (s, 1H), 7.76 (d, J = 2.1 Hz, 
               
               
                   
                 1H), 7.71-7.66 (m, 1H), 7.60 (dt, J = 7.8, 1.3 Hz, 1H), 7.55 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.45 (t, J = 7.6 Hz, 1H), 7.32-7.16 (m, 3H), 7.19-7.08 (m, 3H), 5.62 (t, J = 7.1 Hz, 1H), 
               
               
                   
                 3.80 (m, 1H), 2.10 (m, 1H), 2.04-1.89 (m, 1H), 1.17-1.01 (m, 4H), 0.92 (t, J = 7.3 Hz, 
               
               
                   
                 3H) 
               
               
                 341 
                 1H NMR (400 MHz, Methanol-d4) δ 8.48 (s, 1H), 7.88-7.80 (m, 2H), 7.78 (dt, J = 8.0, 
               
               
                   
                 1.3 Hz, 1H), 7.72-7.64 (m, 2H), 7.55 (t, J = 7.7 Hz, 1H), 7.02 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 4.20 (d, J = 14.0 Hz, 1H), 3.88 (m, 1H), 3.71 (d, J = 14.0 Hz, 1H), 1.24-1.10 (m, 4H), 
               
               
                   
                 0.96 (s, 9H) 
               
               
                 342 
                 1H NMR (400 MHz, DMSO-d6) δ 9.61 (s, 1H), 8.47 (s, 1H), 8.05-7.95 (m, 3H), 
               
               
                   
                 7.67 (d, J = 2.3 Hz, 1H), 7.53-7.41 (m, 3H), 7.39-7.09 (m, 9H), 5.56 (s, 2H) 
               
               
                 343 
                 1H NMR (400 MHz, DMSO-d6) δ 8.33 (s, 1H), 7.99 (s, 1H), 7.61 (s, 1H), 7.57 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.43 (dt, J = 5.9, 3.6 Hz, 2H), 7.29 (dp, J = 7.3, 4.2 Hz, 3H), 6.99 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 3.99-3.89 (m, 1H), 3.77 (dd, J = 13.7, 7.3 Hz, 1H), 3.56 (dd, J = 13.7, 
               
               
                   
                 5.8 Hz, 1H), 1.15-1.09 (m, 2H), 1.09-1.04 (m, 2H), 0.85 (s, 9H). 
               
               
                 344 
                 1H NMR (400 MHz, DMSO-d6) δ 9.03 (s, 1H), 8.29 (s, 1H), 7.56-7.47 (m, 3H), 
               
               
                   
                 7.40 (s, 2H), 7.26 (s, 1H), 7.24-7.16 (m, 2H), 7.07 (d, J = 2.4 Hz, 1H), 3.80 (dd, J = 14.0, 
               
               
                   
                 7.3 Hz, 1H), 3.67 (tt, J = 7.4, 4.2 Hz, 1H), 3.57 (dd, J = 14.0, 6.1 Hz, 1H), 
               
               
                   
                 1.12-1.04 (m, 2H), 1.04-0.96 (m, 2H), 0.85 (s, 9H). 
               
               
                 351 
                 1H NMR (400 MHz, DMSO-d6) δ 9.73 (s, 1H), 8.70 (s, 1H), 8.54-8.31 (m, 1H), 
               
               
                   
                 8.11-7.86 (m, 3H), 7.64-7.02 (m, 6H), 3.92 (s, 1H), 1.14-0.96 (m, 4H) 
               
               
                 355 
                 1H NMR (400 MHz, DMSO-d6) δ 9.55 (d, J = 8.0 Hz, 1H), 8.95 (s, 1H), 8.50 (s, 1H), 
               
               
                   
                 7.93 (d, J = 7.4 Hz, 2H), 7.65 (d, J = 2.3 Hz, 1H), 7.53-7.43 (m, 2H), 7.43-7.32 (m, 
               
               
                   
                 2H), 7.25-7.15 (m, 2H), 7.12 (d, J = 2.4 Hz, 1H), 1.09-0.95 (m, 4H). 
               
               
                 357 
                 1H NMR (400 MHz, DMSO-d6) δ 8.22 (s, 1H), 8.00 (s, 1H), 7.57 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.54-7.49 (m, 1H), 7.48-7.43 (m, 2H), 7.41 (s, 3H), 7.34-7.28 (m, 4H), 
               
               
                   
                 7.26-7.20 (m, 5H), 7.19 (d, J = 2.3 Hz, 2H), 5.42 (q, J = 7.5 Hz, 1H), 3.96 (tt, J = 7.4, 3.7 Hz, 
               
               
                   
                 1H), 2.05 (dq, J = 14.5, 7.2 Hz, 1H), 1.89 (dq, J = 13.7, 7.3, 6.8 Hz, 1H), 
               
               
                   
                 1.20-1.12 (m, 2H), 1.12-1.03 (m, 2H), 0.90 (t, J = 7.3 Hz, 3H). 
               
               
                 358 
                 1H NMR (400 MHz, DMSO-d6) δ 9.60 (s, 1H), 8.53 (s, 1H), 7.97 (s, 1H), 7.82 (t, J = 2.1 Hz, 
               
               
                   
                 1H), 7.73 (ddd, J = 10.9, 8.4, 2.4 Hz, 1H), 7.66 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 7.47-7.43 (m, 1H), 7.42 (d, J = 5.3 Hz, 1H), 7.38-7.35 (m, 1H), 7.33-7.25 (m, 2H), 6.88 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 3.97-3.89 (m, 1H), 1.16-1.07 (m, 2H), 1.07-1.00 (m, 2H). 
               
               
                 359 
                 1H NMR (400 MHz, DMSO-d6) δ 9.53 (s, 1H), 8.45 (s, 1H), 8.15 (s, 1H), 7.98 (s, 
               
               
                   
                 1H), 7.68 (d, J = 2.3 Hz, 1H), 7.52-7.45 (m, 2H), 7.45 (s, 1H), 7.20 (s, 1H), 
               
               
                   
                 7.18-7.11 (m, 2H), 5.56 (tt, J = 9.3, 4.8 Hz, 1H), 4.93-4.81 (m, 2H), 4.71 (m, 2H). 
               
               
                 360 
                 1H NMR (400 MHz, DMSO-d6) δ 9.53 (s, 1H), 8.45 (s, 1H), 8.01 (s, 1H), 7.96 (d, J = 12.8 Hz, 
               
               
                   
                 2H), 7.68 (d, J = 2.3 Hz, 1H), 7.47 (ddd, J = 11.6, 5.9, 3.1 Hz, 3H), 7.19 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.17-7.09 (m, 2H), 5.00 (dtt, J = 18.1, 7.0, 3.7 Hz, 1H), 4.78-4.71 (m, 
               
               
                   
                 1H), 4.67-4.57 (m, 1H), 1.48-1.40 (m, 3H). 
               
               
                 361 
                 1H NMR (400 MHz, DMSO-d6) δ 9.53 (s, 1H), 8.45 (s, 1H), 7.99 (d, J = 8.9 Hz, 2H), 
               
               
                   
                 7.96 (s, 1H), 7.72-7.66 (m, 1H), 7.46 (ddd, J = 8.6, 5.5, 2.6 Hz, 3H), 7.22 (s, 1H), 
               
               
                   
                 7.18-7.11 (m, 2H), 6.59-6.25 (m, 1H), 4.90 (td, J = 15.7, 3.3 Hz, 2H). 
               
               
                 371 
                 1H NMR (400 MHz, DMSO-d6) δ 9.54 (s, 1H), 8.46 (s, 1H), 8.28 (s, 1H), 
               
               
                   
                 8.02-7.90 (m, 2H), 7.68 (d, J = 2.3 Hz, 1H), 7.47 (ddd, J = 10.5, 6.3, 3.6 Hz, 3H), 7.19 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.17-7.07 (m, 2H), 1.79-1.61 (m, 4H). 
               
               
                 376 
                 1H NMR (400 MHz, DMSO-d6) δ 9.63 (s, 1H), 8.54 (s, 1H), 7.86 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 7.83-7.64 (m, 3H), 7.55-7.36 (m, 4H), 7.37-7.27 (m, 2H), 6.93 (s, 1H), 6.22 (d, J = 7.1 Hz, 
               
               
                   
                 1H) 
               
               
                 377 
                 1H NMR (400 MHz, DMSO-d6) δ 9.15 (d, J = 32.1 Hz, 1H), 9.01 (d, J = 3.3 Hz, 1H), 
               
               
                   
                 8.57-8.41 (m, 1H), 8.41-7.91 (m, 2H), 7.93-7.79 (m, 2H), 7.76-6.88 (m, 4H), 
               
               
                   
                 6.58-6.11 (m, 2H), 5.84 (d, J = 6.0 Hz, 1H) 
               
               
                 378 
                 1H NMR (400 MHz, DMSO-d6) δ 9.17 (d, J = 24.8 Hz, 1H), 9.02 (s, 1H), 
               
               
                   
                 8.33-7.77 (m, 4H), 7.77-6.88 (m, 6H), 6.51-6.33 (m, 1H), 5.92 (d, J = 6.5 Hz, 1H) 
               
               
                 379 
                 1H NMR (400 MHz, DMSO-d6) δ 8.34 (d, J = 7.0 Hz, 1H), 8.22 (d, J = 5.1 Hz, 1H), 
               
               
                   
                 7.62-7.55 (m, 3H), 7.43-7.31 (m, 3H), 7.30-7.11 (m, 5H), 6.39-6.31 (m, 1H), 
               
               
                   
                 5.48 (q, J = 7.5 Hz, 1H), 2.22-2.07 (m, 1H), 2.02-1.86 (m, 1H), 1.81-1.63 (m, 4H), 
               
               
                   
                 1.30-1.18 (m, 3H), 0.98-0.84 (m, 3H) 
               
               
                 381 
                 1H NMR (400 MHz, DMSO-d6) δ 9.53 (s, 1H), 8.45 (s, 1H), 8.02 (s, 1H), 7.97 (s, 
               
               
                   
                 2H), 7.68 (d, J = 2.3 Hz, 1H), 7.51-7.44 (m, 2H), 7.40 (s, 1H), 7.15 (d, J = 5.2 Hz, 
               
               
                   
                 1H), 7.14-7.08 (m, 2H), 1.54 (s, 9H). 
               
               
                 382 
                 1H NMR (400 MHz, DMSO-d6) δ 9.54 (s, 1H), 8.45 (s, 1H), 7.97 (s, 2H), 7.67 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.51-7.42 (m, 2H), 7.38 (s, 1H), 7.16 (d, J = 2.4 Hz, 1H), 3.97-3.87 (m, 
               
               
                   
                 1H), 1.10 (m, 2H), 1.08-1.02 (m, 2H). 
               
               
                 393 
                 1H NMR (400 MHz, DMSO-d6) δ 8.88 (s, 1H), 8.85-8.71 (m, 2H), 8.35 (d, J = 2.1 Hz, 
               
               
                   
                 1H), 8.08-7.98 (m, 2H), 7.73 (d, J = 9.7 Hz, 1H), 7.66-7.43 (m, 4H), 
               
               
                   
                 7.24-7.07 (m, 3H), 6.25 (s, 1H), 3.90 (dd, J = 13.8, 7.6 Hz, 1H), 3.53 (dd, J = 13.9, 5.8 Hz, 
               
               
                   
                 1H), 0.83 (s, 9H) 
               
               
                 403 
                 1H NMR (400 MHz, Methanol-d4) δ 8.52 (s, 1H), 8.01 (t, J = 2.1 Hz, 1H), 7.95 (d, J = 0.6 Hz, 
               
               
                   
                 1H), 7.85 (ddd, J = 9.8, 8.2, 2.4 Hz, 1H), 7.69 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 7.51-7.45 (m, 2H), 7.17 (dd, J = 2.4, 0.6 Hz, 1H), 7.15-7.04 (m, 2H), 6.06 (s, 1H), 5.09 (d, J = 6.8 Hz, 
               
               
                   
                 2H), 4.78-4.71 (m, 2H), 1.92 (s, 3H). 
               
               
                 405 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) δ 8.50 (d, J = 2.1 Hz, 1H), 
               
               
                   
                 8.07-7.93 (m, 3H), 7.73 (t, J = 2.2 Hz, 1H), 7.51 (dd, J = 8.1, 5.0 Hz, 2H), 7.27-7.12 (m, 3H), 
               
               
                   
                 6.10 (d, J = 3.5 Hz, 1H), 5.00 (dd, J = 21.8, 3.2 Hz, 2H), 4.82-4.70 (m, 2H), 4.63 (dd, 
               
               
                   
                 J = 20.3, 8.5 Hz, 2H). 
               
               
                 406 
                 1H NMR (400 MHz, DMSO-d6) δ 9.58 (d, J = 2.9 Hz, 1H), 8.51 (s, 1H), 
               
               
                   
                 8.24-8.16 (m, 1H), 8.00 (d, J = 12.9 Hz, 2H), 7.74 (s, 1H), 7.58-7.46 (m, 3H), 7.21 (qd, J = 9.4, 
               
               
                   
                 8.8, 2.2 Hz, 3H), 6.20-6.13 (m, 1H), 5.83 (p, J = 7.1 Hz, 1H), 1.77 (dd, J = 6.6, 1.8 Hz, 
               
               
                   
                 3H). 
               
               
                 407 
                 1H NMR (400 MHz, DMSO-d6) δ 9.61 (s, 1H), 8.51 (d, J = 2.1 Hz, 1H), 8.09 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 8.06-7.97 (m, 2H), 7.74 (d, J = 2.3 Hz, 1H), 7.61-7.45 (m, 3H), 7.26 (t, 
               
               
                   
                 J = 2.4 Hz, 1H), 7.20 (tt, J = 8.9, 2.5 Hz, 2H), 6.38 (td, J = 54.7, 3.4 Hz, 1H), 6.15 (s, 
               
               
                   
                 1H), 5.41-5.12 (m, 1H), 1.61 (dd, J = 7.3, 4.4 Hz, 3H). 
               
               
                 408 
                 1H NMR (400 MHz, DMSO-d6) δ 9.60 (s, 1H), 8.69 (d, J = 1.8 Hz, 1H), 
               
               
                   
                 8.55-8.46 (m, 1H), 8.01 (d, J = 14.9 Hz, 2H), 7.77 (s, 1H), 7.65-7.47 (m, 6H), 7.32-7.13 (m, 
               
               
                   
                 3H), 6.20 (d, J = 7.3 Hz, 1H). 
               
               
                 409 
                 1H NMR (400 MHz, DMSO-d6) δ 9.56 (s, 1H), 8.45 (s, 1H), 8.05-7.91 (m, 3H), 
               
               
                   
                 7.69 (d, J = 2.2 Hz, 1H), 7.47 (ddd, J = 8.7, 5.5, 2.8 Hz, 3H), 7.22 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 7.21-7.08 (m, 2H), 6.42 (tt, J = 54.3, 3.3 Hz, 1H), 6.11 (s, 1H), 4.90 (td, J = 15.7, 3.3 Hz, 
               
               
                   
                 2H). 
               
               
                 410 
                 1H NMR (400 MHz, DMSO-d6) δ 9.54 (s, 1H), 8.45 (s, 1H), 8.07 (s, 1H), 7.96 (d, J = 12.1 Hz, 
               
               
                   
                 2H), 7.68 (d, J = 2.2 Hz, 1H), 7.51-7.42 (m, 3H), 7.21 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 7.19-7.10 (m, 2H), 6.11 (d, J = 7.3 Hz, 1H), 5.74 (s, 2H). 
               
               
                 416 
                 1H NMR (400 MHz, DMSO-d6) δ 8.28 (s, 1H), 7.88 (s, 1H), 7.66-7.47 (m, 4H), 
               
               
                   
                 7.44-7.05 (m, 12H), 6.31 (s, 1H), 5.58-5.39 (m, 1H), 2.23-2.06 (m, 1H), 
               
               
                   
                 2.06-1.89 (m, 1H), 1.03-0.87 (m, 3H) 
               
               
                 417 
                 1H NMR (400 MHz, DMSO-d6) δ 9.45 (s, 1H), 8.47 (s, 1H), 8.25 (s, 1H), 
               
               
                   
                 7.97-7.85 (m, 2H), 7.71 (d, J = 2.3 Hz, 1H), 7.53-7.45 (m, 2H), 7.36 (d, J = 9.4 Hz, 1H), 
               
               
                   
                 7.22-7.08 (m, 3H), 6.08 (s, 1H), 1.82-1.62 (m, 4H) 
               
               
                 420 
                 1H NMR (400 MHz, DMSO-d6) δ 8.38 (s, 1H), 8.18 (s, 1H), 7.79 (s, 1H), 
               
               
                   
                 7.69-7.35 (m, 3H), 7.31-7.04 (m, 3H), 6.21 (s, 1H), 4.03-3.39 (m, 6H), 2.68 (d, J = 9.0 Hz, 
               
               
                   
                 1H), 2.09-1.85 (m, 1H), 1.59 (tq, J = 12.5, 6.8 Hz, 1H) 
               
               
                 426 
                 1H NMR (400 MHz, DMSO-d6) δ 8.70 (dd, J = 4.1, 0.6 Hz, 1H), 8.23-8.22 (m, 1H), 
               
               
                   
                 8.23 (t, J = 56 Hz, 1H), 7.61 (t, J = 2.1 Hz, 1H), 7.50-7.16 (m, 11H), 6.71-6.64 (m, 
               
               
                   
                 1H), 5.53-5.25 (m, 1H), 2.15-1.81 (m, 2H), 0.95-0.84 (m, 3H) 
               
               
                 427 
                 1H NMR (400 MHz, DMSO-d6) δ 8.27 (t, J = 57 Hz, 1H), 8.23 (s, 1H), 7.66 (dd, J = 5.2, 
               
               
                   
                 0.7 Hz, 1H), 7.55-7.38 (m, 3H), 7.35-7.08 (m, 9H), 6.67 (dd, J = 8.4, 4.2 Hz, 
               
               
                   
                 1H), 5.42-5.25 (m, 1H), 2.09-1.77 (m, 2H), 0.92-0.75 (m, 3H) 
               
               
                 428 
                 1H NMR (400 MHz, DMSO-d6) δ 8.30 (d, J = 5.6 Hz, 1H), 8.23 (d, J = 7.7 Hz, 1H), 
               
               
                   
                 8.15 (d, t = 56 Hz, 1H), 7.61 (t, J = 2.4 Hz, 1H), 7.51-7.17 (m, 11H), 6.70 (t, J = 8.8 Hz, 
               
               
                   
                 1H), 5.51-5.28 (m, 1H), 2.15-1.81 (m, 2H), 0.96-0.80 (m, 3H) 
               
               
                 430 
                 1H NMR (400 MHz, DMSO-d6) δ 9.67 (s, 1H), 8.49 (s, 1H), 8.04 (s, 1H), 
               
               
                   
                 8.01-7.90 (m, 2H), 7.71 (d, J = 2.3 Hz, 1H), 7.47 (td, J = 7.9, 1.9 Hz, 1H), 7.42-7.26 (m, 2H), 
               
               
                   
                 7.22-7.08 (m, 3H), 6.21 (s, 1H), 4.01-3.89 (m, 1H), 1.18-0.96 (m, 4H) 
               
               
                 431 
                 1H NMR (400 MHz, DMSO-d6) δ 9.68 (s, 1H), 8.48 (s, 1H), 8.04-7.92 (m, 2H), 
               
               
                   
                 7.77 (s, 1H), 7.73 (d, J = 2.3 Hz, 1H), 7.44 (td, J = 7.7, 1.8 Hz, 1H), 7.40-7.28 (m, 2H), 
               
               
                   
                 7.25-7.12 (m, 3H), 6.23 (s, 1H), 3.96 (s, 2H), −0.01 (s, 9H) 
               
               
                 435 
                 1H NMR (400 MHz, DMSO-d6) δ 9.58 (s, 1H), 8.45 (s, 1H), 8.03-7.89 (m, 2H), 
               
               
                   
                 7.73 (d, J = 2.2 Hz, 1H), 7.50-7.39 (m, 2H), 7.32 (s, 1H), 7.14-7.04 (m, 4H), 5.88 (s, 1H), 
               
               
                   
                 3.84 (s, 3H). 
               
               
                 444 
                 1H NMR (400 MHz, DMSO-d6) δ 8.31 (s, 1H), 7.89 (d, J = 8.6 Hz, 1H), 7.80 (d, J = 3.5 Hz, 
               
               
                   
                 1H), 7.68-7.61 (m, 1H), 7.53-7.42 (m, 1H), 7.41-7.09 (m, 11H), 6.54 (s, 
               
               
                   
                 1H), 5.54-5.34 (m, 1H), 2.16-2.00 (m, 1H), 2.04-1.84 (m, 1H), 0.94-0.83 (m, 
               
               
                   
                 3H) 
               
               
                 445 
                 1H NMR (400 MHz, DMSO-d6) δ 8.29 (s, 1H), 7.92-7.83 (m, 1H), 7.79 (d, J = 8.5 Hz, 
               
               
                   
                 1H), 7.68-7.60 (m, 1H), 7.49-7.09 (m, 11H), 6.63-6.55 (m, 1H), 
               
               
                   
                 5.58-5.44 (m, 1H), 2.16-1.82 (m, 2H), 0.95-0.81 (m, 3H) 
               
               
                 446 
                 1H NMR (400 MHz, DMSO-d6) δ 8.25 (d, J = 2.9 Hz, 1H), 8.03 (d, J = 2.1 Hz, 1H), 
               
               
                   
                 7.70 (d, J = 8.6 Hz, 1H), 7.66-7.59 (m, 1H), 7.56-7.46 (m, 1H), 7.44-7.10 (m, 
               
               
                   
                 11H), 6.57-6.46 (m, 1H), 5.47 (td, J = 7.9, 6.3 Hz, 1H), 4.89-4.81 (m, 1H), 
               
               
                   
                 4.77-4.62 (m, 3H), 2.16-1.81 (m, 2H), 0.94-0.83 (m, 3H) 
               
               
                 447 
                 1H NMR (400 MHz, DMSO-d6) δ 9.64 (s, 1H), 8.45 (s, 1H), 7.99-7.90 (m, 2H), 
               
               
                   
                 7.77-7.65 (m, 2H), 7.52-7.25 (m, 3H), 7.23-7.05 (m, 3H), 6.26 (d, J = 6.0 Hz, 1H), 
               
               
                   
                 4.85 (s, 2H) 
               
               
                 448 
                 1H NMR (400 MHz, DMSO-d6) δ 9.60 (s, 1H), 8.46 (s, 1H), 8.01-7.89 (m, 2H), 
               
               
                   
                 7.80 (s, 1H), 7.70 (d, J = 2.2 Hz, 1H), 7.42 (d, J = 8.5 Hz, 1H), 7.38-7.27 (m, 1H), 
               
               
                   
                 7.25 (dd, J = 7.8, 6.1 Hz, 1H), 7.21-7.09 (m, 2H), 6.29 (d, J = 8.1 Hz, 1H), 3.91 (s, 2H) 
               
               
                 469 
                 1H NMR (400 MHz, DMSO-d6) δ 9.59-9.51 (m, 2H), 8.79 (s, 1H), 8.53-8.32 (m, 
               
               
                   
                 1H), 7.99 (s, 1H), 7.94-7.83 (m, 1H), 7.71 (s, 1H), 7.61-7.42 (m, 3H), 
               
               
                   
                 7.42-7.23 (m, 5H), 7.18 (dd, J = 6.7, 2.9 Hz, 1H), 6.53 (d, J = 4.1 Hz, 1H), 6.12 (d, J = 7.6 Hz, 
               
               
                   
                 1H), 4.95 (s, 1H), 4.42 (t, J = 7.1 Hz, 2H), 3.69-3.41 (m, 2H), 3.23-3.06 (m, 2H), 
               
               
                   
                 2.96 (q, J = 10.7, 9.0 Hz, 2H), 2.30-2.09 (m, 2H), 2.07-1.90 (m, 2H), 1.90-1.74 (m, 
               
               
                   
                 1H). 
               
               
                 470 
                 1H NMR (400 MHz, DMSO-d6) δ 9.53 (s, 1H), 9.03 (s, 1H), 8.78 (s, 1H), 
               
               
                   
                 8.53-8.33 (m, 1H), 7.99 (s, 1H), 7.89 (s, 1H), 7.71 (s, 1H), 7.64-7.41 (m, 4H), 7.41-7.22 (m, 
               
               
                   
                 5H), 7.18 (dd, J = 6.5, 2.9 Hz, 1H), 6.52 (d, J = 4.1 Hz, 1H), 6.10 (d, J = 7.5 Hz, 1H), 
               
               
                   
                 4.80 (ddt, J = 11.8, 8.6, 4.4 Hz, 1H), 3.66 (d, J = 12.0 Hz, 2H), 3.12 (q, J = 11.7 Hz, 
               
               
                   
                 2H), 2.44-2.30 (m, 1H), 2.30-2.12 (m, 2H), 1.35 (s, 9H). 
               
               
                 471 
                 1H NMR (400 MHz, DMSO-d6) δ 9.65 (s, 1H), 9.01 (s, 2H), 8.78 (s, 1H), 
               
               
                   
                 8.50-8.32 (m, 1H), 8.01 (s, 1H), 7.67 (s, 2H), 7.58 (s, 1H), 7.55-7.45 (m, 2H), 7.45-7.22 (m, 
               
               
                   
                 5H), 7.18 (dd, J = 6.8, 3.0 Hz, 1H), 6.52 (d, J = 4.1 Hz, 0H), 6.10 (d, J = 7.9 Hz, 1H), 
               
               
                   
                 5.06-4.67 (m, 1H), 3.62 (dd, J = 27.7, 13.0 Hz, 3H), 3.21-3.05 (m, 1H), 
               
               
                   
                 2.45-2.30 (m, 1H), 2.25 (d, J = 23.7 Hz, 1H), 1.35 (s, 9H). 
               
               
                 472 
                 1H NMR (400 MHz, DMSO-d6) δ 9.53 (s, 1H), 9.21 (s, 1H), 8.44-8.30 (m, 1H), 
               
               
                   
                 8.01 (s, 1H), 7.70 (s, 1H), 7.58-7.43 (m, 3H), 7.43-7.23 (m, 6H), 7.18 (dd, J = 6.7, 3.0 Hz, 
               
               
                   
                 1H), 6.52 (d, J = 4.2 Hz, 1H), 6.17 (d, J = 8.6 Hz, 1H), 4.58-4.28 (m, 2H), 
               
               
                   
                 3.63-3.41 (m, 1H), 3.13 (dt, J = 10.3, 5.8 Hz, 2H), 2.95 (q, J = 11.7, 9.5 Hz, 3H), 
               
               
                   
                 2.26-2.08 (m, 2H), 1.99 (d, J = 6.8 Hz, 2H), 1.83 (dd, J = 7.5, 4.9 Hz, 1H). 
               
               
                 473 
                 1H NMR (400 MHz, DMSO-d6) δ 9.20 (s, 1H), 8.99 (d, J = 10.4 Hz, 1H), 8.77 (d, J = 5.4 Hz, 
               
               
                   
                 1H), 8.44-8.28 (m, 1H), 8.01 (s, 1H), 7.71 (s, 1H), 7.59-7.41 (m, 4H), 
               
               
                   
                 7.40-7.21 (m, 5H), 7.18 (dd, J = 6.7, 2.9 Hz, 1H), 6.52 (d, J = 4.1 Hz, 1H), 6.15 (d, J = 8.2 Hz, 
               
               
                   
                 1H), 5.02-4.69 (m, 1H), 3.66 (d, J = 12.1 Hz, 2H), 3.12 (d, J = 11.7 Hz, 2H), 
               
               
                   
                 2.43-2.31 (m, 2H), 2.23 (d, J = 12.7 Hz, 1H), 1.35 (s, 9H). 
               
               
                 489 
                 1H NMR (400 MHz, DMSO-d6) δ 9.27 (d, J = 10.7 Hz, 1H), 8.49 (s, 1H), 8.34 (s, 1H), 
               
               
                   
                 8.00 (s, 1H), 7.71-7.40 (m, 4H), 7.40-7.13 (m, 4H), 6.17 (d, J = 5.8 Hz, 1H), 
               
               
                   
                 4.96-4.71 (m, 1H), 3.85-3.56 (m, 3H), 3.42 (dd, J = 15.5, 6.2 Hz, 1H), 3.13 (dt, J = 12.9, 
               
               
                   
                 10.2 Hz, 2H), 2.45-2.14 (m, 4H), 1.36 (s, 9H), 0.09 (s, 9H) 
               
               
                 493 
                 1H NMR (400 MHz, DMSO-d6) δ 9.63 (s, 1H), 8.47 (s, 1H), 8.07-7.94 (m, 3H), 
               
               
                   
                 7.71 (d, J = 2.2 Hz, 1H), 7.57-7.41 (m, 3H), 7.26-7.10 (m, 3H), 6.11 (s, 1H), 4.85 (dd, J = 5.2, 
               
               
                   
                 4.1 Hz, 1H), 4.78-4.61 (m, 3H) 
               
               
                 514 
                 1H NMR (400 MHz, DMSO-d6) δ 9.45 (m, 2H), 8.39 (s, 1H), 7.92 (d, J = 8.0 Hz, 1H), 
               
               
                   
                 7.68 (t, J = 1.8 Hz, 1H), 7.53-7.14 (m, 11H), 6.17-5.99 (m, 1H), 5.88 (m, 1H), 
               
               
                   
                 4.49 (m, 1H), 4.06 (m, 1H), 3.19 (m, 2H), 3.04 (m, 1H), 2.87 (m, 1H), 2.36-2.17 (m, 2H), 
               
               
                   
                 1.23 (t, J = 7.3 Hz, 3H). 
               
               
                 515 
                 1H NMR (400 MHz, DMSO-d6) δ 9.43 (s, 1H), 8.91 (d, J = 11.2 Hz, 1H), 8.67 (s, 1H), 
               
               
                   
                 8.39 (s, 1H), 7.90 (d, J = 7.9 Hz, 1H), 7.68 (dd, J = 2.3, 1.2 Hz, 1H), 7.54-7.15 (m, 
               
               
                   
                 10H), 6.08 (s, 1H), 4.66-4.41 (m, 1H), 3.93 (m, 1H) 3.36 (d, J = 12.7 Hz, 2H), 
               
               
                   
                 3.01 (d, J = 11.7 Hz, 1H), 2.91-2.70 (m, 1H), 2.35-2.09 (m, 2H). 
               
               
                 516 
                 1H NMR (400 MHz, DMSO-d6) δ 9.59 (brs, 1H), 9.40 (s, 1H), 8.45 (s, 1H), 7.90 (d, J = 9.0 Hz, 
               
               
                   
                 1H), 7.77-7.62 (m, 1H), 7.49-7.14 (m, 10H), 7.09 (ddt, J = 8.2, 2.2, 1.1 Hz, 
               
               
                   
                 1H), 5.94 (m, 1H), 4.57-4.38 (m, 1H), 4.05 (m, 1H), 3.60-3.48 (m, 3H), 3.18 (m, 
               
               
                   
                 2H), 3.04 (m, 1H), 2.87 (m, 1H), 2.40-2.15 (m, 2H), 1.22 (t, J = 7.3 Hz, 3H). 
               
               
                 530 
                 1H NMR (400 MHz, DMSO-d6) δ 9.53 (s, 1H), 8.44 (s, 1H), 8.09 (d, J = 0.5 Hz, 1H), 
               
               
                   
                 7.71 (s, 1H), 7.56 (dd, J = 8.9, 1.7 Hz, 1H), 7.48-7.19 (m, 8H), 6.12 (d, J = 7.8 Hz, 
               
               
                   
                 1H), 5.07 (s, 0H), 4.87 (t, J = 6.9 Hz, 2H), 4.6 (brs, 1H), 3.75 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 3.37-3.26 (m, 4H), 2.95 (s, 3H), 1.12 (td, J = 7.2, 2.7 Hz, 6H) 
               
               
                 532 
                 1H NMR (400 MHz, DMSO-d6) δ 8.47-6.25 (m, 14H), 5.34 (d, J = 7.5 Hz, 1H), 
               
               
                   
                 4.04 (s, 3H), 2.11-1.68 (m, 2H), 0.90 (d, J = 9.7 Hz, 3H) 
               
               
                 533 
                 1H NMR (400 MHz, DMSO-d6) δ 8.26 (d, J = 3.8 Hz, 1H), 7.78 (s, 1H), 7.61 (d, J = 2.2 Hz, 
               
               
                   
                 2H), 7.56-7.38 (m, 4H), 7.38-7.16 (m, 8H), 6.57 (d, J = 7.0 Hz, 1H), 
               
               
                   
                 5.52-5.29 (m, 1H), 2.17-1.82 (m, 2H), 0.91 (td, J = 7.3, 2.3 Hz, 3H) 
               
               
                 534 
                 1H NMR (400 MHz, DMSO-d6) δ 9.70-9.44 (m, 1H), 8.44 (s, 1H), 7.98 (s, 1H), 
               
               
                   
                 7.70 (d, J = 2.2 Hz, 1H), 7.55 (dd, J = 8.9, 1.7 Hz, 1H), 7.50-7.43 (m, 2H), 7.43-7.19 (m, 
               
               
                   
                 5H), 6.06 (s, 1H), 5.58-4.51 (m, 2H), 2.20-2.04 (m, 2H), 1.95-1.80 (m, 2H), 
               
               
                   
                 1.80-1.54 (m, 4H) 
               
               
                 536 
                 1H NMR (400 MHz, DMSO-d6) δ 8.14 (s, 1H), 7.91 (s, 1H), 7.59-7.50 (m, 3H), 
               
               
                   
                 7.35-7.25 (m, 5H), 7.25-7.14 (m, 5H), 6.31 (d, J = 8.2 Hz, 1H), 5.41 (q, J = 7.6 Hz, 1H), 
               
               
                   
                 4.36 (t, J = 7.0 Hz, 2H), 3.39 (t, J = 6.7 Hz, 2H), 2.15-1.94 (m, 5H), 1.92-1.82 (m, 
               
               
                   
                 2H), 1.74 (d, J = 29.8 Hz, 6H), 0.91 (t, J = 7.3 Hz, 3H) 
               
               
                 538 
                 1H NMR (400 MHz, DMSO-d6) δ 9.03 (s, 1H), 8.22 (s, 1H), 8.00 (s, 1H), 
               
               
                   
                 7.69-7.52 (m, 3H), 7.36 (dd, J = 12.1, 6.5 Hz, 3H), 7.30-7.08 (m, 7H), 6.34 (d, J = 7.4 Hz, 1H), 
               
               
                   
                 5.46 (q, J = 7.5 Hz, 1H), 4.90-4.72 (m, 1H), 3.68 (d, J = 12.1 Hz, 2H), 3.13 (q, J = 11.7 Hz, 
               
               
                   
                 2H), 2.46-2.20 (m, 4H), 2.12 (dd, J = 14.1, 7.0 Hz, 1H), 2.03-1.83 (m, 
               
               
                   
                 1H), 1.36 (s, 9H), 0.94 (t, J = 7.3 Hz, 3H) 
               
               
                 543 
                 1H NMR (400 MHz, DMSO-d6) δ 9.13 (s, 1H), 8.30 (s, 1H), 7.98 (s, 1H), 7.61 (d, J = 2.2 Hz, 
               
               
                   
                 2H), 7.57-7.48 (m, 2H), 7.39 (s, 1H), 7.36-7.27 (m, 2H), 7.27-7.19 (m, 
               
               
                   
                 1H), 7.16 (d, J = 2.4 Hz, 1H), 6.17 (d, J = 5.0 Hz, 1H), 4.80 (tt, J = 11.6, 4.5 Hz, 1H), 
               
               
                   
                 3.95 (dd, J = 13.9, 7.8 Hz, 1H), 3.67 (d, J = 12.0 Hz, 2H), 3.48 (dd, J = 13.9, 5.6 Hz, 
               
               
                   
                 1H), 3.12 (q, J = 11.4 Hz, 2H), 2.46-2.17 (m, 4H), 1.36 (s, 9H), 0.89 (s, 9H) 
               
               
                 544 
                 1H NMR (400 MHz, DMSO-d6) δ 9.45 (s, 1H), 8.39 (s, 1H), 8.16 (s, 1H), 7.69 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.48-7.42 (m, H), 7.38-7.31 (m, 3H), 7.27 (dd, J = 6.6, 1.9 Hz, 2H), 
               
               
                   
                 7.25-7.19 (m, 1H), 6.16-6.06 (m, 1H), 4.97 (s, 2H), 4.70 (dd, J = 14.1, 8.7 Hz, 2H), 
               
               
                   
                 4.61 (d, J = 8.7 Hz, 1H), 4.54 (d, J = 8.7 Hz, 1H), 3.49-3.27 (m, 4H), 1.91 (s, 4H). 
               
               
                 545 
                 1H NMR (400 MHz, DMSO-d6) δ 9.55 (s, 1H), 9.42 (s, 1H), 8.40 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.95 (d, J = 2.2 Hz, 1H), 7.68 (t, J = 2.3 Hz, 1H), 7.51-7.38 (m, 4H), 7.32 (ddd, J = 8.7, 
               
               
                   
                 7.2, 2.1 Hz, 2H), 7.28-7.18 (m, 3H), 6.06 (d, J = 6.9 Hz, 1H), 4.45-4.36 (m, 2H), 
               
               
                   
                 3.52 (d, J = 11.2 Hz, 2H), 3.12 (q, J = 7.1 Hz, 2H), 2.94 (p, J = 7.6 Hz, 2H), 2.16 (qd, J = 8.1, 
               
               
                   
                 5.7 Hz, 2H), 1.96 (d, J = 7.6 Hz, 3H), 1.89-1.75 (m, 2H). 
               
               
                 546 
                 1H NMR (400 MHz, DMSO-d6) δ 9.75 (s, 1H), 9.43 (s, 1H), 8.40 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 8.00 (d, J = 2.2 Hz, 1H), 7.68 (t, J = 2.4 Hz, 1H), 7.49-7.39 (m, 4H), 7.34 (qd, J = 7.4, 
               
               
                   
                 3.8 Hz, 2H), 7.24 (tdd, J = 9.0, 6.7, 2.4 Hz, 3H), 6.18-6.00 (m, 1H), 4.71 (ddd, J = 7.8, 
               
               
                   
                 4.5, 1.9 Hz, 2H), 3.66 (dd, J = 7.9, 3.9 Hz, 2H), 3.45 (s, 2H), 2.98 (d, J = 10.4 Hz, 
               
               
                   
                 2H), 1.93 (d, J = 7.8 Hz, 2H), 1.81 (dd, J = 15.4, 8.6 Hz, 2H). 
               
               
                 548 
                 1H NMR (400 MHz, Methanol-d4) δ 8.46 (s, 1H), 7.83 (s, 1H), 7.67 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.59-7.51 (m, 1H), 7.48-7.28 (m, 5H), 7.27-7.18 (m, 2H), 6.03 (s, 1H), 
               
               
                   
                 4.81-4.73 (m, 1H), 3.80 (d, J = 12.6 Hz, 2H), 3.61 (m, 2H), 3.28-3.17 (m, 2H), 2.48 (m, 
               
               
                   
                 4H), 2.37 (m, 2H), 1.92 (m, 4H), 1.46 (s, 9H) 
               
               
                 555 
                 1H NMR (400 MHz, DMSO-d6) δ 9.08 (s, 1H), 8.31 (s, 1H), 8.00 (s, 1H), 7.59 (d, J = 2.1 Hz, 
               
               
                   
                 1H), 7.57-7.51 (m, 2H), 7.41 (s, 1H), 7.38-7.21 (m, 3H), 7.14 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 6.13 (d, J = 6.0 Hz, 1H), 4.80 (td, J = 11.7, 5.9 Hz, 1H), 3.90 (dd, J = 13.3, 
               
               
                   
                 6.6 Hz, 1H), 3.76-3.60 (m, 3H), 3.12 (q, J = 11.7, 11.1 Hz, 2H), 2.29 (dt, J = 36.9, 
               
               
                   
                 12.2 Hz, 4H), 1.36 (s, 10H), 1.15 (d, J = 3.8 Hz, 6H) 
               
               
                 564 
                 1H NMR (400 MHz, Methanol-d4) δ 8.40 (s, 1H), 7.95 (s, 1H), 7.64 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.55-7.46 (m, 1H), 7.40 (m, 2H), 7.31 (m, 7H), 6.28 (s, 1H), 5.74 (t, J = 7.2 Hz, 
               
               
                   
                 1H), 4.87-4.76 (m, 1H), 3.81 (d, J = 12.7 Hz, 2H), 3.23 (t, J = 11.6 Hz, 2H), 3.17 (s, 
               
               
                   
                 3H), 2.55-2.35 (m, 4H), 2.20 (m, 1H), 2.07 (m, 1H), 1.62 (s, 3H), 1.46 (s, 9H), 
               
               
                   
                 1.01 (t, J = 7.3 Hz, 3H) 
               
               
                 567 
                 1H NMR (400 MHz, Methanol-d4) δ 8.48 (s, 1H), 7.78 (s, 1H), 7.68 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.59-7.56 (m, 2H), 7.47-7.33 (m, 4H), 7.26 (d, J = 2.4 Hz, 1H), 6.06 (s, 1H), 
               
               
                   
                 4.84-4.76 (m, 1H), 3.27 (s, 3H), 2.82 (s, 3H), 1.53 (dd, J = 6.7, 1.6 Hz, 6H) 
               
               
                 569 
                 1H NMR (400 MHz, DMSO-d6) δ 9.23 (s, 1H), 8.23 (d, J = 4.9 Hz, 1H), 8.01 (d, J = 2.8 Hz, 
               
               
                   
                 1H), 7.68-7.52 (m, 4H), 7.45-7.14 (m, 11H), 6.32 (d, J = 3.4 Hz, 1H), 
               
               
                   
                 5.80-5.68 (m, 1H), 4.83 (tt, J = 11.7, 4.4 Hz, 1H), 3.13 (dt, J = 14.6, 10.7 Hz, 2H), 
               
               
                   
                 2.43-2.21 (m, 4H), 1.67 (d, J = 6.7, 3.7 Hz, 3H), 1.36 (s, 9H) 
               
               
                 570 
                 1H NMR (400 MHz, DMSO-d6) δ 9.69 (s, 1H), 9.39 (s, 1H), 8.40 (s, 1H), 7.99 (s, 
               
               
                   
                 1H), 7.68 (d, J = 2.2 Hz, 1H), 7.56 (t, J = 1.8 Hz, 1H), 7.48 (dt, J = 7.7, 1.6 Hz, 1H), 
               
               
                   
                 7.46-7.40 (m, 2H), 7.40 (m, 2H), 7.22-7.15 (m, 2H), 6.11-6.04 (m, 1H), 4.77 (p, J = 6.7 Hz, 
               
               
                   
                 1H), 4.29 (d, J = 5.6 Hz, 2H), 3.34-3.16 (m, 2H), 2.99 (ddt, J = 21.0, 15.3, 7.9 Hz, 
               
               
                   
                 2H), 1.90 (q, J = 5.0, 4.3 Hz, 2H), 1.72 (p, J = 8.5 Hz, 2H), 1.45 (d, J = 2.1 Hz, 
               
               
                   
                 3H), 1.43 (d, J = 2.1 Hz, 3H). 
               
               
                 572 
                 1H NMR (400 MHz, DMSO-d6) δ 9.47 (brs, 1H), 8.99 (brs, 1H), 8.39 (d, J = 27.5 Hz, 
               
               
                   
                 1H), 8.01 (s, 1H), 7.75-7.65 (m, 1H), 7.64-7.17 (m, 7H), 6.12 (d, J = 7.8 Hz, 1H), 
               
               
                   
                 4.79 (ddt, J = 11.5, 8.2, 4.3 Hz, 1H), 3.71-3.56 (m, 2H), 3.10 (q, J = 11.5 Hz, 2H), 
               
               
                   
                 2.90 (s, 3H), 2.73 (s, 3H), 2.42-2.30 (m, 2H), 2.23 (t, J = 12.9 Hz, 2H), 1.34 (s, 9H). 
               
               
                 574 
                 1H NMR (400 MHz, DMSO-d6) δ 9.43 (s, 1H), 8.40 (s, 1H), 8.02 (s, 1H), 7.67 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.47 (dd, J = 6.6, 2.7 Hz, 1H), 7.45-7.38 (m, 4H), 7.36-7.28 (m, 3H), 
               
               
                   
                 7.27-7.19 (m, 4H), 6.04 (d, J = 5.7 Hz, 1H), 4.73 (t, J = 7.5 Hz, 3H), 4.58 (dd, J = 8.0, 
               
               
                   
                 5.0 Hz, 3H), 4.38 (s, 1H), 4.11 (s, 1H), 3.80 (s, 1H), 3.28 (s, 2H), 2.63 (d, J = 15.7 Hz, 
               
               
                   
                 3H). 
               
               
                 575 
                 1H NMR (400 MHz, DMSO-d6) δ 9.74 (s, 1H), 9.43 (s, 1H), 8.40 (s, 1H), 7.75 (d, J = 3.0 Hz, 
               
               
                   
                 1H), 7.68 (d, J = 2.2 Hz, 1H), 7.54 (t, J = 1.7 Hz, 1H), 7.50-7.35 (m, 6H), 
               
               
                   
                 7.21 (qd, J = 5.1, 4.7, 2.7 Hz, 3H), 6.13 (d, J = 6.8 Hz, 1H), 4.29 (d, J = 5.7 Hz, 2H), 
               
               
                   
                 3.40-3.17 (m, 2H), 3.10-2.94 (m, 2H), 1.91 (tdd, J = 12.7, 9.0, 4.6 Hz, 2H), 
               
               
                   
                 1.84-1.65 (m, 2H). 
               
               
                 577 
                 1H NMR (400 MHz, DMSO-d6) δ 9.40 (s, 1H), 9.19 (s, 1H), 8.66 (s, 1H), 8.39 (s, 
               
               
                   
                 1H), 8.01 (s, 1H), 7.66 (d, J = 2.2 Hz, 1H), 7.46 (dd, J = 6.6, 2.7 Hz, 1H), 
               
               
                   
                 7.45-7.38 (m, 3H), 7.34-7.29 (m, 3H), 7.27-7.18 (m, 3H), 6.03 (d, J = 7.3 Hz, 1H), 3.90 (t, J = 2.5 Hz, 
               
               
                   
                 1H), 3.59-3.49 (m, 2H), 3.44 (q, J = 9.5, 8.5 Hz, 2H), 2.56 (q, J = 2.2 Hz, 
               
               
                   
                 2H). 
               
               
                 582 
                 1H NMR (400 MHz, DMSO-d6) δ 9.61 (s, 1H), 8.46 (s, 1H), 8.06-7.97 (m, 2H), 
               
               
                   
                 7.72 (d, J = 2.3 Hz, 2H), 7.50-7.40 (m, 4H), 7.32 (tt, J = 6.7, 0.8 Hz, 3H), 7.29-7.19 (m, 
               
               
                   
                 3H), 6.12 (s, 1H). 
               
               
                 586 
                 1H NMR (400 MHz, DMSO-d6) δ 8.83 (s, 1H), 8.45-8.34 (m, 1H), 8.00 (s, 1H), 
               
               
                   
                 7.68-7.48 (m, 4H), 7.44-7.13 (m, 5H), 6.22 (s, 1H), 4.86-4.70 (m, 1H), 4.50-4.38 (m, 
               
               
                   
                 1H), 1.91-1.29 (m, 10H), 0.93 (t, J = 7.4 Hz, 3H) 
               
               
                 587 
                 1H NMR (400 MHz, DMSO-d6) δ 9.15 (s, 1H), 8.33 (s, 1H), 7.99 (s, 1H), 
               
               
                   
                 7.61-7.49 (m, 3H), 7.39-7.17 (m, 6H), 6.23 (s, 1H), 4.87-4.73 (m, 1H), 4.44-4.31 (m, 1H), 
               
               
                   
                 3.12 (q, J = 11.1 Hz, 2H), 2.39-2.17 (m, 5H), 1.89-1.73 (m, 1H), 1.71-1.55 (m, 
               
               
                   
                 1H), 1.40-1.28 (m, 13H), 0.91 (t, J = 7.4 Hz, 3H) 
               
               
                 588 
                 1H NMR (400 MHz, DMSO-d6) δ 8.27 (s, 1H), 8.01 (s, 1H), 7.77 (d, J = 8.6 Hz, 1H), 
               
               
                   
                 7.67-7.52 (m, 3H), 7.44 (s, 1H), 7.43-7.14 (m, 10H), 6.29 (s, 1H), 5.77 (p, J = 6.9 Hz, 
               
               
                   
                 1H), 4.81 (p, J = 6.7 Hz, 1H), 1.69 (d, J = 6.7 Hz, 3H), 1.59-1.39 (m, 6H) 
               
               
                 589 
                 1H NMR (400 MHz, DMSO-d6) δ 8.38 (s, 1H), 8.02 (d, J = 16.9 Hz, 1H), 
               
               
                   
                 7.66-7.46 (m, 3H), 7.44-7.14 (m, 7H), 4.78 (dhept, J = 15.7, 6.7 Hz, 1H), 4.37 (qd, J = 8.0, 5.7 Hz, 
               
               
                   
                 1H), 3.24 (s, 1H), 1.85-1.59 (m, 2H), 1.59-1.29 (m, 11H) 
               
               
                 590 
                 1H NMR (400 MHz, DMSO-d6) δ 9.08-9.03 (m, 1H), 8.31 (s, 1H), 7.99 (s, 1H), 
               
               
                   
                 7.60-7.47 (m, 3H), 7.42-7.15 (m, 6H), 6.22 (d, J = 6.5 Hz, 1H), 4.88-4.74 (m, 1H), 
               
               
                   
                 4.32 (p, J = 7.2 Hz, 1H), 3.19-3.05 (m, 2H), 2.42-2.33 (m, 2H), 2.31-2.20 (m, 
               
               
                   
                 2H), 1.81-1.58 (m, 2H), 1.40-1.27 (m, 13H), 0.77 (t, J = 7.3 Hz, 3H) 
               
               
                 591 
                 1H NMR (400 MHz, DMSO-d6) δ 9.48 (s, 1H), 8.39 (d, J = 11.8 Hz, 1H), 7.98 (s, 1H), 
               
               
                   
                 7.70 (d, J = 2.2 Hz, 1H), 7.56-7.43 (m, 3H), 7.42-7.14 (m, 7H), 6.11-6.06 (m, 
               
               
                   
                 1H), 4.78 (hept, J = 6.7 Hz, 1H), 1.44 (dd, J = 6.7, 1.0 Hz, 6H).) 
               
               
                 592 
                 1H NMR (400 MHz, DMSO-d6) δ 8.27 (s, 1H), 7.99 (s, 1H), 7.68-7.52 (m, 4H), 
               
               
                   
                 7.48-7.14 (m, 11H), 6.32 (s, 1H), 5.51 (q, J = 7.6 Hz, 1H), 4.88-4.73 (m, 1H), 
               
               
                   
                 2.23-2.07 (m, 1H), 2.04-1.86 (m, 1H), 1.47 (dd, J = 6.6, 1.5 Hz, 6H), 0.99-0.87 (m, 3H) 
               
               
                 596 
                 1H NMR (400 MHz, DMSO-d6) δ 9.03 (d, J = 11.0 Hz, 1H), 8.29 (d, J = 4.4 Hz, 1H), 
               
               
                   
                 7.97 (d, J = 4.4 Hz, 1H), 7.62-7.43 (m, 2H), 7.41-7.12 (m, 5H), 6.97 (d, J = 6.5 Hz, 
               
               
                   
                 1H), 6.27 (dd, J = 13.8, 6.6 Hz, 1H), 4.88-4.64 (m, 1H), 4.52 (d, J = 8.5 Hz, 1H), 
               
               
                   
                 3.67 (d, J = 11.9 Hz, 2H), 3.13 (s, 2H), 2.43-2.05 (m, 5H), 1.61-1.42 (m, 1H), 
               
               
                   
                 1.41-1.29 (m, 9H), 1.25-1.12 (m, 2H) 
               
               
                 597 
                 1H NMR (400 MHz, DMSO-d6) δ 9.02 (d, J = 14.1 Hz, 1H), 8.34-8.23 (m, 1H), 
               
               
                   
                 7.99 (s, 1H), 7.98-7.91 (m, 1H), 7.67-7.46 (m, 2H), 7.42-7.30 (m, 1H), 7.30-7.17 (m, 
               
               
                   
                 2H), 6.23 (d, J = 7.2 Hz, 1H), 4.89-4.71 (m, 1H), 4.21 (d, J = 10.3 Hz, 1H), 3.88 (s, 
               
               
                   
                 1H), 3.67 (d, J = 12.2 Hz, 2H), 3.13 (q, J = 11.8 Hz, 2H), 2.46-2.16 (m, 3H), 
               
               
                   
                 2.07-1.86 (m, 1H), 1.86-1.70 (m, 2H), 1.70-1.45 (m, 2H), 1.36 (s, 9H) 
               
               
                 600 
                 1H NMR (400 MHz, Methanol-d4) δ 8.40 (d, J = 1.3 Hz, 1H), 7.90 (s, 1H), 
               
               
                   
                 7.68-7.59 (m, 2H), 7.53 (s, 1H), 7.46 (t, J = 7.4 Hz, 1H), 7.42-7.37 (m, 2H), 7.38-7.26 (m, 
               
               
                   
                 5H), 6.28 (s, 1H), 5.74 (t, J = 7.2 Hz, 1H), 4.85-4.78 (m, 1H), 3.81 (d, J = 12.5 Hz, 
               
               
                   
                 2H), 3.23 (t, J = 12.5 Hz, 2H), 3.04 (s, 3H), 2.82 (s, 3H), 2.57-2.32 (m, 4H), 
               
               
                   
                 2.27-2.01 (m, 2H), 1.46 (s, 9H), 1.01 (t, J = 7.4 Hz, 3H) 
               
               
                 608 
                 1H NMR (400 MHz, Methanol-d4) δ 8.45 (s, 1H), 7.86 (s, 1H), 7.67 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.57 (d, J = 7.6 Hz, 1H), 7.53-7.43 (m, 3H), 7.37 (d, J = 7.7 Hz, 1H), 
               
               
                   
                 7.34-7.28 (m, 1H), 7.24 (t, J = 8.0 Hz, 1H), 7.19 (d, J = 2.4 Hz, 1H), 6.09 (s, 1H), 
               
               
                   
                 4.83-4.72 (m, 1H), 3.80 (d, J = 12.5 Hz, 2H), 3.22 (t, J = 12.4 Hz, 2H), 3.05 (s, 3H), 2.87 (s, 
               
               
                   
                 3H), 2.52-2.31 (m, 4H), 1.46 (s, 9H) 
               
               
                 609 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) δ 8.40 (s, 1H), 7.93 (s, 1H), 7.65 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.49 (dd, J = 6.6, 2.7 Hz, 1H), 7.47-7.38 (m, 4H), 7.33-7.27 (m, 3H), 
               
               
                   
                 7.27-7.18 (m, 4H), 6.02 (s, 1H), 3.94-3.84 (m, 1H), 1.06 (m, 4H). 
               
               
                 610 
                 1H NMR (400 MHz, DMSO-d6) δ 9.54 (s, 1H), 8.41 (s, 1H), 7.80 (s, 1H), 7.69 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.50 (dd, J = 6.6, 2.6 Hz, 1H), 7.47-7.40 (m, 3H), 7.35-7.29 (m, 2H), 
               
               
                   
                 7.29 (d, J = 2.3 Hz, 1H), 7.27-7.21 (m, 2H), 6.09 (s, 1H), 4.22 (s, 2H), 1.01 (d, J = 1.6 Hz, 
               
               
                   
                 6H). 
               
               
                 613 
                 1H NMR (400 MHz, DMSO-d6) δ 9.55-9.47 (m, 1H), 8.42 (s, 1H), 7.78-7.68 (m, 
               
               
                   
                 2H), 7.57-7.20 (m, 11H), 6.15 (s, 1H) 
               
               
                 614 
                 1H NMR (400 MHz, DMSO-d6) δ 10.38 (s, 1H), 9.49 (s, 1H), 8.33 (s, 1H), 7.79 (s, 
               
               
                   
                 1H), 7.66 (d, J = 2.3 Hz, 1H), 7.56-7.29 (m, 5H), 7.13 (dd, J = 8.7, 2.6 Hz, 1H), 
               
               
                   
                 7.00 (d, J = 8.6 Hz, 1H), 6.20 (d, J = 6.9 Hz, 1H) 
               
               
                 623 
                 1H NMR (400 MHz, Methanol-d4) δ 8.44 (s, 1H), 7.92 (s, 1H), 7.65 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.50-7.42 (m, 3H), 7.39 (s, 1H), 7.32 (t, J = 8.8 Hz, 1H), 7.25 (d, J = 6.3 Hz, 
               
               
                   
                 2H), 7.18 (d, J = 2.4 Hz, 1H), 6.07 (s, 1H), 4.85-4.75 (m, 1H), 3.80 (d, J = 12.6 Hz, 
               
               
                   
                 2H), 3.22 (t, J = 12.4 Hz, 1H), 3.18 (s, 3H), 2.49-2.36 (m, 4H), 1.71 (s, 3H), 1.46 (s, 
               
               
                   
                 9H) 
               
               
                 626 
                 1H NMR (400 MHz, DMSO-d6) δ 8.26 (s, 1H), 7.59 (d, J = 2.0 Hz, 1H), 
               
               
                   
                 7.53-7.14 (m, 14H), 6.57 (s, 1H), 5.40-5.29 (m, 2H), 1.97-1.87 (m, 1H), 1.78 (s, 1H), 
               
               
                   
                 0.83-0.75 (m, 3H) 
               
               
                 627 
                 1H NMR (400 MHz, DMSO-d6) δ 8.30 (s, 1H), 7.76 (q, J = 8.3, 7.3 Hz, 2H), 7.64 (d, J = 2.1 Hz, 
               
               
                   
                 1H), 7.60-7.44 (m, 3H), 7.44-7.19 (m, 10H), 6.36 (s, 1H), 5.60-5.46 (m, 
               
               
                   
                 1H), 2.13 (tq, J = 14.0, 7.0 Hz, 1H), 1.95 (dp, J = 14.1, 7.6 Hz, 1H), 0.95 (t, J = 7.3 Hz, 
               
               
                   
                 3H) 
               
               
                 628 
                 1H NMR (400 MHz, DMSO-d6) δ 9.49 (s, 1H), 9.23-9.13 (m, 1H), 8.41 (d, J = 1.1 Hz, 
               
               
                   
                 1H), 7.99 (s, 1H), 7.73-7.68 (m, 1H), 7.56-7.21 (m, 8H), 6.11 (d, J = 4.0 Hz, 
               
               
                   
                 1H), 4.87-4.74 (m, 1H), 3.69-3.61 (m, 2H), 3.19-3.05 (m, 2H), 2.57-2.47 (m, 
               
               
                   
                 1H), 2.39-2.16 (m, 4H), 1.35 (s, 9H) 
               
               
                 629 
                 1H NMR (400 MHz, DMSO-d6) δ 9.22 (t, J = 9.9 Hz, 1H), 8.23 (s, 1H), 8.00 (s, 1H), 
               
               
                   
                 7.64-7.54 (m, 3H), 7.50-7.14 (m, 10H), 6.34 (d, J = 4.0 Hz, 1H), 5.48 (q, J = 7.4 Hz, 
               
               
                   
                 1H), 4.82 (tt, J = 11.9, 4.4 Hz, 1H), 3.67 (d, J = 12.0 Hz, 2H), 3.13 (dt, J = 14.5, 
               
               
                   
                 10.6 Hz, 2H), 2.42-2.20 (m, 4H), 2.21-2.06 (m, 1H), 2.02-1.84 (m, 1H), 1.36 (s, 
               
               
                   
                 9H), 1.02-0.87 (m, 3H) 
               
               
                 631 
                 1H NMR (400 MHz, DMSO-d6) δ 9.48 (s, 1H), 8.39 (d, J = 6.2 Hz, 1H), 7.80 (s, 1H), 
               
               
                   
                 7.69 (d, J = 2.1 Hz, 1H), 7.59-7.37 (m, 4H), 7.33 (q, J = 6.9 Hz, 2H), 6.18 (d, J = 7.4 Hz, 
               
               
                   
                 1H) 
               
               
                 638 
                 1H NMR (400 MHz, DMSO-d6) δ 9.68 (s, 1H), 8.32 (s, 1H), 8.15 (d, J = 0.9 Hz, 1H), 
               
               
                   
                 7.82-7.70 (m, 3H), 7.67 (d, J = 2.3 Hz, 1H), 7.49-7.38 (m, 5H), 7.35 (dd, J = 8.9, 2.0 Hz, 
               
               
                   
                 1H), 7.33-7.22 (m, 3H), 7.22-7.16 (m, 2H), 6.18 (d, J = 7.5 Hz, 1H), 5.72 (s, 
               
               
                   
                 3H) 
               
               
                 639 
                 1H NMR (400 MHz, DMSO-d6) δ 9.40 (s, 1H), 8.41 (d, J = 19.9 Hz, 1H), 7.79 (s, 1H), 
               
               
                   
                 7.69 (d, J = 2.2 Hz, 1H), 7.57-7.43 (m, 4H), 7.43-7.35 (m, 4H), 7.29 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 6.15 (d, J = 7.3 Hz, 1H) 
               
               
                 640 
                 1H NMR (400 MHz, DMSO-d6) δ 9.23 (s, 1H), 8.74 (s, 1H), 8.37 (d, J = 5.8 Hz, 1H), 
               
               
                   
                 7.81 (s, 1H), 7.69 (s, 1H), 7.55-7.44 (m, 2H), 7.45-7.34 (m, 3H), 7.34-7.22 (m, 
               
               
                   
                 2H), 7.21-7.14 (m, 1H), 6.20 (d, J = 8.0 Hz, 1H) 
               
               
                 644 
                 1H NMR (400 MHz, DMSO-d6) δ 8.42 (s, 1H), 7.78-7.63 (m, 2H), 7.53 (dd, J = 8.8, 
               
               
                   
                 1.7 Hz, 1H), 7.48-7.17 (m, 9H), 6.11 (s, 1H). 
               
               
                 645 
                 1H NMR (400 MHz, Methanol-d4) δ 8.44 (s, 1H), 7.87 (s, 1H), 7.78 (s, 1H), 
               
               
                   
                 7.69-7.58 (m, 3H), 7.50 (d, J = 7.8 Hz, 1H), 7.48-7.41 (m, 1H), 7.37-7.21 (m, 1H), 
               
               
                   
                 7.17 (d, J = 2.4 Hz, 1H), 6.11 (s, 1H), 4.83-4.75 (m, 1H), 4.52 (br s, 4H), 3.80 (d, J = 12.2 Hz, 
               
               
                   
                 2H), 3.22 (t, J = 11.8 Hz, 2H), 2.55-2.30 (m, 4H), 1.46 (s, 9H) 
               
               
                 646 
                 1H NMR (400 MHz, Methanol-d4) δ 8.43 (s, 1H), 7.85 (s, 1H), 7.74 (s, 1H), 7.66 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.63 (d, J = 7.8 Hz, 1H), 7.58 (d, J = 7.7 Hz, 1H), 7.52-7.41 (m, 2H), 
               
               
                   
                 7.31 (t, J = 8.8 Hz, 1H), 7.27-7.20 (m, 1H), 7.16 (d, J = 2.4 Hz, 1H), 6.10 (s, 1H), 
               
               
                   
                 5.31 (d, J = 57.3 Hz, 1H), 4.83-4.71 (m, 1H), 4.50-4.10 (m, 4H), 3.80 (d, J = 12.5 Hz, 
               
               
                   
                 2H), 3.21 (t, J = 12.9 Hz, 2H), 2.58-2.28 (m, 4H), 1.46 (s, 9H) 
               
               
                 647 
                 1H NMR (400 MHz, DMSO-d6) δ 9.38 (s, 1H), 8.39 (d, J = 4.8 Hz, 1H), 
               
               
                   
                 7.85-7.71 (m, 3H), 7.69 (d, J = 2.1 Hz, 1H), 7.52-7.43 (m, 2H), 7.43-7.37 (m, 2H), 7.33 (d, J = 4.2 Hz, 
               
               
                   
                 1H), 7.19 (d, J = 5.5 Hz, 1H), 6.19 (d, J = 7.7 Hz, 1H), 5.25 (s, 1H), 
               
               
                   
                 1.32-1.09 (m, 2H) 
               
               
                 648 
                 1H NMR (400 MHz, DMSO-d6) δ 9.42 (s, 1H), 8.73 (s, 1H), 8.35 (s, 1H), 7.78 (s, 
               
               
                   
                 1H), 7.66 (d, J = 2.2 Hz, 1H), 7.53-7.46 (m, 3H), 7.46-7.38 (m, 7H), 7.38-7.30 (m, 
               
               
                   
                 2H), 7.30-7.22 (m, 2H), 6.17 (d, J = 7.9 Hz, 1H), 5.24 (s, 2H) 
               
               
                 649 
                 1H NMR (400 MHz, DMSO-d6) δ 9.43 (s, 1H), 8.34 (s, 1H), 7.78 (s, 1H), 7.66 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.51-7.44 (m, 2H), 7.44-7.36 (m, 3H), 7.33 (s, 1H), 7.28-7.13 (m, 
               
               
                   
                 2H), 6.18 (d, J = 7.9 Hz, 1H), 4.15 (t, J = 7.0 Hz, 2H), 1.38 (t, J = 7.0 Hz, 3H) 
               
               
                 650 
                 1H NMR (400 MHz, DMSO-d6) δ 9.47 (s, 1H), 9.09 (s, 2H), 8.79 (d, J = 4.5 Hz, 1H), 
               
               
                   
                 8.43-8.35 (m, 1H), 8.03 (s, 1H), 7.69 (d, J = 1.9 Hz, 1H), 7.51 (d, J = 8.5 Hz, 2H), 
               
               
                   
                 7.47-7.37 (m, 2H), 7.37-7.27 (m, 1H), 7.22-7.14 (m, 1H), 6.53 (d, J = 4.1 Hz, 
               
               
                   
                 1H), 6.15 (d, J = 8.3 Hz, 1H), 4.95 (s, 1H), 4.80 (ddt, J = 11.7, 8.6, 4.3 Hz, 1H), 
               
               
                   
                 3.66 (d, J = 12.1 Hz, 2H), 3.19-3.06 (m, 2H), 2.36 (d, J = 13.5 Hz, 2H), 2.24 (q, J = 13.0 Hz, 
               
               
                   
                 2H), 1.36 (s, 9H), 1.31 (d, J = 11.0 Hz, 2H) 
               
               
                 651 
                 1H NMR (400 MHz, DMSO-d6) δ 9.36 (s, 1H), 8.99 (s, 1H), 8.39 (d, J = 7.7 Hz, 1H), 
               
               
                   
                 8.02 (s, 1H), 7.84-7.66 (m, 3H), 7.62 (d, J = 7.6 Hz, 1H), 7.55-7.38 (m, 4H), 
               
               
                   
                 7.38-7.28 (m, 1H), 7.18 (d, J = 4.3 Hz, 1H), 6.15 (d, J = 8.5 Hz, 1H), 4.95 (s, 1H), 
               
               
                   
                 4.86-4.75 (m, 1H), 3.66 (d, J = 12.2 Hz, 2H), 3.12 (q, J = 11.6 Hz, 2H), 2.36 (d, J = 13.8 Hz, 
               
               
                   
                 2H), 2.23 (q, J = 13.0 Hz, 2H), 1.35 (s, 9H) 
               
               
                 652 
                 1H NMR (400 MHz, DMSO-d6) δ 9.37 (s, 1H), 8.97 (s, 1H), 8.44 (s, 1H), 8.38 (d, J = 2.6 Hz, 
               
               
                   
                 0H), 8.15 (s, 1H), 8.01 (s, 1H), 7.69 (s, 1H), 7.58-7.44 (m, 3H), 
               
               
                   
                 7.45-7.33 (m, 4H), 7.33-7.22 (m, 1H), 7.18 (d, J = 4.1 Hz, 1H), 6.52 (d, J = 4.2 Hz, 1H), 
               
               
                   
                 6.11 (d, J = 8.3 Hz, 1H), 4.85-4.74 (m, 1H), 3.66 (d, J = 12.1 Hz, 2H), 3.12 (q, J = 11.4 Hz, 
               
               
                   
                 2H), 2.36 (d, J = 12.5 Hz, 2H), 2.23 (q, J = 12.8 Hz, 2H), 1.35 (s, 9H) 
               
               
                 653 
                 1H NMR (400 MHz, DMSO-d6) δ 9.22 (s, 1H), 9.01 (s, 1H), 8.38 (d, J = 4.7 Hz, 1H), 
               
               
                   
                 8.04 (s, 1H), 7.69 (s, 1H), 7.61-7.47 (m, 2H), 7.47-7.40 (m, 2H), 7.37 (d, J = 9.2 Hz, 
               
               
                   
                 1H), 7.34-7.22 (m, 2H), 6.16 (d, J = 8.5 Hz, 1H), 4.89-4.73 (m, 1H), 3.66 (d, J = 12.2 Hz, 
               
               
                   
                 2H), 3.13 (dd, J = 21.9, 10.6 Hz, 2H), 2.36 (d, J = 14.1 Hz, 2H), 2.24 (d, J = 13.0 Hz, 
               
               
                   
                 1H), 1.35 (s, 9H) 
               
               
                 654 
                 1H NMR (400 MHz, DMSO-d6) δ 9.33 (s, 1H), 8.96 (s, 1H), 8.35 (s, 1H), 8.01 (s, 
               
               
                   
                 1H), 7.65 (d, J = 2.2 Hz, 1H), 7.52-7.46 (m, 4H), 7.46-7.39 (m, 5H), 7.39-7.34 (m, 
               
               
                   
                 1H), 7.30-7.25 (m, 2H), 7.22 (dd, J = 8.8, 2.5 Hz, 1H), 6.12 (d, J = 8.6 Hz, 1H), 
               
               
                   
                 5.24 (s, 2H), 4.88-4.66 (m, 1H), 3.66 (d, J = 12.0 Hz, 2H), 3.12 (q, J = 11.4 Hz, 2H), 
               
               
                   
                 2.43-2.29 (m, 2H), 2.24 (t, J = 12.8 Hz, 2H), 1.35 (s, 9H) 
               
               
                 655 
                 1H NMR (400 MHz, DMSO-d6) δ 9.33 (s, 1H), 8.96 (s, 1H), 8.36 (d, J = 19.4 Hz, 1H), 
               
               
                   
                 8.01 (s, 1H), 7.65 (d, J = 2.2 Hz, 1H), 7.54-7.46 (m, 1H), 7.46-7.32 (m, 3H), 7.30 (d, 
               
               
                   
                 J = 2.5 Hz, 1H), 7.26-7.13 (m, 1H), 6.14 (d, J = 8.6 Hz, 1H), 4.86-4.70 (m, 1H), 
               
               
                   
                 4.14 (q, J = 6.9 Hz, 1H), 3.66 (d, J = 12.0 Hz, 1H), 3.16-3.05 (m, 1H), 2.36 (d, J = 13.1 Hz, 
               
               
                   
                 1H), 2.30-2.19 (m, 1H), 1.42-1.22 (m, 9H) 
               
               
                 664 
                 1H NMR (400 MHz, DMSO-d6) δ 9.42 (s, 1H), 8.99 (s, 1H), 8.77 (s, 1H), 8.47 (s, 
               
               
                   
                 1H), 8.41-8.35 (m, 0H), 8.02 (s, 1H), 7.88 (d, J = 10.4 Hz, 1H), 7.71 (d, J = 12.5 Hz, 
               
               
                   
                 2H), 7.66-7.52 (m, 1H), 7.52-7.45 (m, 3H), 7.45-7.39 (m, 2H), 7.37-7.29 (m, 1H), 
               
               
                   
                 7.25 (s, 1H), 7.22-7.15 (1, 0H), 6.52 (d, J = 4.0 Hz, 1H), 6.11 (d, J = 8.2 Hz, 1H), 
               
               
                   
                 4.85-4.74 (m, 1H), 3.65 (d, J = 12.0 Hz, 2H), 3.12 (q, J = 11.3 Hz, 2H), 2.35 (d, J = 12.7 Hz, 
               
               
                   
                 2H), 2.24 (t, J = 13.1 Hz, 2H), 1.35 (s, 9H) 
               
               
                 665 
                 1H NMR (400 MHz, DMSO-d6) δ 9.55 (s, 1H), 8.96 (s, 1H), 8.37 (d, J = 12.8 Hz, 1H), 
               
               
                   
                 8.03 (s, 1H), 7.68 (s, 1H), 7.54-7.47 (m, 2H), 7.48-7.37 (m, 2H), 7.33 (d, J = 4.0 Hz, 
               
               
                   
                 1H), 6.14 (d, J = 8.4 Hz, 1H), 4.89-4.71 (m, 1H), 3.67 (d, J = 12.2 Hz, 2H), 3.12 (q, J = 10.4, 
               
               
                   
                 9.5 Hz, 2H), 2.35 (t, J = 10.4 Hz, 2H), 2.25 (t, J = 12.8 Hz, 1H), 1.35 (s, 9H) 
               
               
                 666 
                 1H NMR (400 MHz, DMSO-d6) δ 9.47 (s, 1H), 8.40 (s, 1H), 7.94 (s, 1H), 7.67 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.48 (dd, J = 6.6, 2.6 Hz, 1H), 7.45-7.39 (m, 3H), 7.35-7.29 (m, 2H), 
               
               
                   
                 7.28-7.20 (m, 3H), 6.06 (s, 1H), 4.46 (t, J = 5.9 Hz, 1H), 4.42 (t, J = 7.1 Hz, 2H), 
               
               
                   
                 4.34 (t, J = 5.7 Hz, 1H), 2.23-2.15 (m, 1H), 2.15-2.08 (m, 1H). 
               
               
                 669 
                 1H NMR (400 MHz, DMSO-d6) δ 9.47 (s, 1H), 8.40 (s, 1H), 7.95 (s, 1H), 7.68 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.49 (dd, J = 6.6, 2.6 Hz, 1H), 7.47-7.38 (m, 4H), 7.37-7.30 (m, 3H), 
               
               
                   
                 7.28 (d, J = 2.4 Hz, 1H), 7.28-7.20 (m, 3H), 6.42 (tt, J = 54.4, 3.3 Hz, 1H), 6.11 (s, 
               
               
                   
                 1H), 4.91 (td, J = 15.7, 3.3 Hz, 2H). 
               
               
                 670 
                 1H NMR (400 MHz, DMSO-d6) δ 9.37 (s, 1H), 8.37 (s, 1H), 7.89 (s, 1H), 7.66 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.49-7.37 (m, 4H), 7.32 (td, J = 8.1, 6.8 Hz, 3H), 7.26-7.18 (m, 3H), 
               
               
                   
                 6.04 (d, J = 8.6 Hz, 1H), 4.60 (t, J = 5.1 Hz, 1H), 4.35 (dd, J = 7.5, 6.7 Hz, 2H), 
               
               
                   
                 3.34 (td, J = 6.1, 5.0 Hz, 2H), 1.94-1.83 (m, 2H). 
               
               
                 677 
                 1H NMR (400 MHz, DMSO-d6) δ 9.11 (s, 1H), 8.23 (d, J = 3.2 Hz, 1H), 8.03 (d, J = 6.1 Hz, 
               
               
                   
                 1H), 7.68-7.53 (m, 3H), 7.48-7.34 (m, 4H), 7.34-7.12 (m, 5H), 6.35 (d, J = 7.2 Hz, 
               
               
                   
                 1H), 5.47 (q, J = 7.5 Hz, 1H), 4.93-4.75 (m, 1H), 3.68 (d, J = 11.9 Hz, 2H), 
               
               
                   
                 3.14 (q, J = 11.1, 10.6 Hz, 2H), 2.47-2.20 (m, 4H), 2.14 (dt, J = 14.2, 7.3 Hz, 1H), 
               
               
                   
                 2.05-1.79 (m, 1H), 1.37 (s, 9H), 1.03-0.77 (m, 3H) 
               
               
                 683 
                 1H NMR (400 MHz, DMSO-d6) δ 9.10 (s, 1H), 8.32 (s, 1H), 8.03 (s, 1H), 
               
               
                   
                 7.67-7.48 (m, 3H), 7.48-7.30 (m, 2H), 7.18 (s, 1H), 6.20 (d, J = 7.7 Hz, 1H), 4.97-4.75 (m, 
               
               
                   
                 1H), 3.98-3.59 (m, 4H), 3.13 (q, J = 11.6 Hz, 2H), 2.44-2.16 (m, 4H), 1.66 (qd, J = 7.4, 
               
               
                   
                 2.6 Hz, 2H), 1.52-1.21 (m, 10H), 0.92 (t, J = 7.4 Hz, 3H) 
               
               
                 684 
                 1H NMR (400 MHz, DMSO-d6) δ 9.76 (s, 1H), 9.52 (s, 1H), 9.20 (s, 1H), 8.41 (s, 
               
               
                   
                 1H), 8.01 (s, 1H), 7.68 (d, J = 2.2 Hz, 1H), 7.53-7.43 (m, 4H), 7.43-7.36 (m, 2H), 
               
               
                   
                 7.34-7.26 (m, 2H), 7.13 (d, J = 8.5 Hz, 1H), 6.71 (d, J = 8.5 Hz, 1H), 6.11 (d, J = 8.3 Hz, 
               
               
                   
                 1H), 4.80 (dq, J = 11.6, 5.8, 4.6 Hz, 1H), 4.31 (d, J = 5.1 Hz, 2H), 3.66 (d, J = 11.9 Hz, 
               
               
                   
                 2H), 3.12 (q, J = 11.3 Hz, 2H), 2.76-2.70 (m, 5H), 2.65 (d, J = 4.9 Hz, 1H), 
               
               
                   
                 2.36 (d, J = 13.7 Hz, 2H), 2.25 (d, J = 12.7 Hz, 1H), 1.36 (s, 9H) 
               
               
                 686 
                 1H NMR (400 MHz, DMSO-d6) δ 9.56 (s, 1H), 9.04 (s, 1H), 8.31 (s, 1H), 8.15 (d, J = 0.9 Hz, 
               
               
                   
                 1H), 8.00 (s, 1H), 7.78 (dt, J = 9.0, 0.9 Hz, 1H), 7.68 (dd, J = 18.9, 2.1 Hz, 
               
               
                   
                 2H), 7.48 (d, J = 8.6 Hz, 2H), 7.44-7.39 (m, 2H), 7.36 (dd, J = 11.5, 2.2 Hz, 2H), 
               
               
                   
                 7.33-7.25 (m, 3H), 7.22-7.17 (m, 2H), 6.52 (d, J = 4.1 Hz, 0H), 6.13 (d, J = 8.1 Hz, 
               
               
                   
                 1H), 5.72 (s, 2H), 4.85-4.74 (m, 1H), 3.52 (s, 1H), 3.11 (q, J = 11.3 Hz, 2H), 2.36 (d, 
               
               
                   
                 J = 13.4 Hz, 2H), 2.24 (q, J = 12.9 Hz, 2H), 1.35 (s, 9H). 
               
               
                 687 
                 1H NMR (400 MHz, DMSO-d6) δ 9.37 (s, 1H), 8.97 (s, 1H), 8.30 (s, 1H), 8.03 (s, 
               
               
                   
                 1H), 7.66 (d, J = 2.2 Hz, 1H), 7.57-7.46 (m, 2H), 7.46-7.36 (m, 3H), 7.35-7.20 (m, 
               
               
                   
                 3H), 6.12 (d, J = 8.2 Hz, 1H), 4.87-4.72 (m, 1H), 3.67 (d, J = 12.0 Hz, 2H), 3.12 (d, J = 11.7 Hz, 
               
               
                   
                 1H), 2.36 (d, J = 13.6 Hz, 2H), 2.24 (d, J = 12.9 Hz, 1H), 2.16 (s, 3H), 
               
               
                   
                 1.36 (s, 9H) 
               
               
                 689 
                 1H NMR (400 MHz, DMSO-d6) δ 9.61 (s, 1H), 9.06 (s, 1H), 8.47 (s, 1H), 8.01 (s, 
               
               
                   
                 1H), 7.94 (d, J = 2.3 Hz, 1H), 7.66-7.37 (m, 6H), 7.34-7.25 (m, 1H), 6.13 (d, J = 8.3 Hz, 
               
               
                   
                 1H), 4.86-4.73 (m, 1H), 3.65 (d, J = 12.1 Hz, 2H), 3.11 (q, J = 11.4, 10.9 Hz, 
               
               
                   
                 2H), 2.39-2.16 (m, 4H), 1.35 (s, 9H) 
               
               
                 692 
                 1H NMR (400 MHz, DMSO-d6) δ 9.54 (s, 1H), 9.02 (s, 1H), 8.78 (s, 1H), 8.55 (s, 
               
               
                   
                 1H), 8.38 (dd, J = 10.6, 7.6 Hz, 2H), 7.99 (s, 1H), 7.72 (d, J = 2.3 Hz, 1H), 7.65 (t, J = 2.1 Hz, 
               
               
                   
                 1H), 7.52 (d, J = 8.2 Hz, 1H), 7.48-7.43 (m, 2H), 7.42-7.33 (m, 3H), 
               
               
                   
                 7.33-7.28 (m, 1H), 7.18 (dd, J = 6.8, 3.0 Hz, 1H), 7.10 (s, 1H), 6.52 (d, J = 4.1 Hz, 1H), 
               
               
                   
                 6.02 (d, J = 7.9 Hz, 1H), 4.95 (s, 1H), 4.84-4.73 (m, 1H), 3.65 (d, J = 11.8 Hz, 2H), 
               
               
                   
                 3.11 (q, J = 11.1, 10.6 Hz, 2H), 2.34 (d, J = 13.6 Hz, 2H), 2.22 (q, J = 13.2 Hz, 2H), 1.35 (s, 
               
               
                   
                 9H) 
               
               
                 693 
                 1H NMR (400 MHz, DMSO-d6) δ 9.37 (s, 1H), 9.00 (s, 1H), 8.39 (d, J = 7.4 Hz, 1H), 
               
               
                   
                 8.16 (s, 1H), 8.03 (s, 1H), 7.87-7.72 (m, 2H), 7.69 (s, 1H), 7.55-7.47 (m, 2H), 
               
               
                   
                 7.46-7.38 (m, 2H), 7.30 (s, 1H), 6.14 (d, J = 8.5 Hz, 1H), 4.86-4.75 (m, 1H), 3.66 (d, J = 12.2 Hz, 
               
               
                   
                 2H), 3.12 (q, J = 11.4 Hz, 2H), 2.36 (d, J = 13.8 Hz, 3H), 2.23 (q, J = 13.0 Hz, 
               
               
                   
                 2H), 1.35 (s, 9H), 1.30 (s, 1H) 
               
               
                 694 
                 1H NMR (400 MHz, DMSO-d6) δ 9.36 (s, 1H), 8.99 (s, 1H), 8.44-8.35 (m, 1H), 
               
               
                   
                 8.04 (s, 1H), 7.71 (s, 2H), 7.56-7.47 (m, 2H), 7.47-7.37 (m, 2H), 7.35 (s, 2H), 
               
               
                   
                 7.25-7.08 (m, 1H), 7.00-6.90 (m, 1H), 6.67 (ddd, J = 9.0, 7.9, 5.3 Hz, 1H), 6.52 (d, J = 4.1 Hz, 
               
               
                   
                 1H), 6.14 (d, J = 8.3 Hz, 1H), 4.95 (s, 1H), 4.86-4.75 (m, 1H), 3.66 (d, J = 12.1 Hz, 
               
               
                   
                 2H), 3.12 (q, J = 11.6 Hz, 2H), 2.36 (d, J = 13.4 Hz, 2H), 2.24 (q, J = 12.9, 12.4 Hz, 
               
               
                   
                 2H), 1.35 (s, 9H) 
               
               
                 695 
                 1H NMR (400 MHz, DMSO-d6) δ 9.45 (s, 1H), 9.02 (s, 1H), 8.39 (d, J = 4.6 Hz, 1H), 
               
               
                   
                 8.03 (s, 1H), 7.69 (s, 1H), 7.55-7.47 (m, 1H), 7.47-7.38 (m, 1H), 7.32 (d, J = 2.6 Hz, 
               
               
                   
                 1H), 6.14 (d, J = 8.5 Hz, 1H), 4.88-4.73 (m, 1H), 3.66 (d, J = 12.2 Hz, 2H), 3.12 (q, J = 11.5 Hz, 
               
               
                   
                 2H), 2.36 (d, J = 13.6 Hz, 2H), 2.25 (t, J = 12.8 Hz, 2H), 1.35 (s, 9H) 
               
               
                 696 
                 1H NMR (400 MHz, DMSO-d6) δ 9.49 (s, 1H), 8.96 (s, 1H), 8.59 (s, 1H), 7.98 (s, 
               
               
                   
                 1H), 7.73 (d, J = 2.3 Hz, 1H), 7.51 (d, J = 7.9 Hz, 1H), 7.47-7.28 (m, 4H), 7.08 (dt, J = 8.7, 
               
               
                   
                 2.1 Hz, 1H), 7.04-6.93 (m, 2H), 6.85 (dt, J = 10.5, 2.1 Hz, 1H), 5.97 (d, J = 7.6 Hz, 
               
               
                   
                 1H), 4.83-4.72 (m, 1H), 3.65 (d, J = 12.1 Hz, 2H), 3.15-3.04 (m, 2H), 2.35 (s, 
               
               
                   
                 1H), 2.23 (t, J = 13.0 Hz, 2H), 1.35 (s, 9H) 
               
               
                 700 
                 1H NMR (400 MHz, DMSO-d6) δ 10.36 (s, 1H), 9.30 (s, 1H), 8.30 (s, 1H), 8.04 (s, 
               
               
                   
                 1H), 7.64 (d, J = 2.2 Hz, 1H), 7.53-7.39 (m, 4H), 7.39-7.29 (m, 3H), 7.10 (dd, J = 8.7, 
               
               
                   
                 2.6 Hz, 1H), 6.99 (d, J = 8.6 Hz, 1H), 6.16 (d, J = 8.6 Hz, 1H), 4.74 (s, 6H), 
               
               
                   
                 3.54 (s, 2H), 3.00 (s, 2H), 2.36 (s, 2H), 2.19 (s, 2H) 
               
               
                 701 
                 1H NMR (400 MHz, DMSO-d6) δ 10.36 (s, 1H), 9.29 (s, 1H), 8.95 (s, 1H), 8.30 (s, 
               
               
                   
                 1H), 8.01 (s, 1H), 7.73-7.61 (m, 1H), 7.54-7.47 (m, 2H), 7.46-7.39 (m, 2H), 
               
               
                   
                 7.36 (d, J = 8.6 Hz, 1H), 7.31 (d, J = 2.7 Hz, 1H), 7.19 (s, 1H), 7.10 (dd, J = 8.6, 2.6 Hz, 
               
               
                   
                 1H), 7.00 (d, J = 8.6 Hz, 1H), 6.16 (d, J = 8.8 Hz, 1H), 4.83-4.74 (m, 1H), 3.97 (s, 
               
               
                   
                 1H), 3.66 (d, J = 12.1 Hz, 2H), 3.12 (d, J = 11.9 Hz, 1H), 2.36 (d, J = 13.5 Hz, 2H), 
               
               
                   
                 2.24 (t, J = 12.9 Hz, 2H), 1.35 (s, 9H) 
               
               
                 707 
                 1H NMR (400 MHz, DMSO-d6) δ 9.46 (s, 1H), 8.90 (d, J = 12.3 Hz, 1H), 8.36 (s, 1H), 
               
               
                   
                 7.97 (s, 2H), 7.80-7.55 (m, 1H), 7.58-7.35 (m, 7H), 7.35-7.14 (m, 2H), 7.10 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 6.10 (d, J = 8.0 Hz, 1H), 5.34-5.13 (m, 1H), 2.19 (t, J = 9.9 Hz, 2H), 
               
               
                   
                 2.03 (t, J = 12.9 Hz, 2H), 1.46 (s, 6H), 1.40 (s, 6H) 
               
               
                 708 
                 1H NMR (400 MHz, DMSO-d6) δ 10.65 (s, 1H), 9.48 (s, 1H), 8.37 (s, 1H), 8.03 (s, 
               
               
                   
                 1H), 7.55-7.34 (m, 6H), 7.36-7.22 (m, 2H), 7.10 (d, J = 2.2 Hz, 1H), 6.10 (d, J = 7.7 Hz, 
               
               
                   
                 1H), 4.75 (d, J = 6.8 Hz, 5H), 4.40 (s, 1H), 3.53 (s, 1H), 3.00 (s, 2H), 2.36 (s, 2H), 
               
               
                   
                 2.19 (d, J = 13.6 Hz, 2H) 
               
               
                 709 
                 1H NMR (400 MHz, DMSO-d6) δ 9.44 (s, 1H), 9.02 (d, J = 14.7 Hz, 1H), 8.36 (s, 1H), 
               
               
                   
                 8.00 (s, 1H), 7.54-7.37 (m, 6H), 7.35-7.21 (m, 2H), 7.09 (s, 1H), 6.09 (d, J = 8.1 Hz, 
               
               
                   
                 1H), 4.95-4.70 (m, 1H), 3.66 (d, J = 12.0 Hz, 2H), 3.12 (q, J = 11.7 Hz, 2H), 2.35 (d, 
               
               
                   
                 J = 12.8 Hz, 2H), 2.23 (q, J = 13.0 Hz, 2H), 1.35 (s, 9H) 
               
               
                 711 
                 1H NMR (400 MHz, Methanol-d4) δ 8.42 (s, 1H), 8.02 (s, 1H), 7.72 (s, 1H), 
               
               
                   
                 7.66-7.59 (m, 2H), 7.55 (t, J = 7.5 Hz, 1H), 7.51 (d, J = 7.7 Hz, 1H), 7.36 (dd, J = 6.4, 2.6 Hz, 
               
               
                   
                 1H), 7.27 (t, J = 8.8 Hz, 1H), 7.18 (m, 1H), 7.12 (d, J = 2.3 Hz, 1H), 6.07 (s, 1H), 
               
               
                   
                 4.85-4.77 (m, 1H), 4.61 (s, 2H), 3.65 (dd, J = 10.7, 5.4 Hz, 2H), 3.54 (dd, J = 10.2, 
               
               
                   
                 5.4 Hz, 2H), 3.10 (d, J = 6.5 Hz, 6H), 1.54 (d, J = 6.7 Hz, 6H) 
               
               
                 712 
                 1H NMR (400 MHz, Methanol-d4) δ 8.44 (s, 1H), 7.94 (s, 1H), 7.65 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.63 (s, 1H), 7.56 (d, J = 7.7 Hz, 1H), 7.50 (t, J = 7.6 Hz, 1H), 7.43 (m, 2H), 
               
               
                   
                 7.30 (t, J = 8.8 Hz, 1H), 7.23 (m, 1H), 7.16 (d, J = 2.4 Hz, 1H), 6.07 (s, 1H), 4.86-4.76 (m, 
               
               
                   
                 1H), 4.30 (d, J = 12.9 Hz, 1H), 4.26 (d, J = 12.9 Hz, 1H), 2.80 (s, 6H), 1.54 (d, J = 6.7 Hz, 
               
               
                   
                 6H) 
               
               
                 713 
                 1H NMR (400 MHz, Methanol-d4) δ 8.47 (s, 1H), 7.72 (s, 1H), 7.68 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.59-7.52 (m, 1H), 7.48 (s, 1H), 7.41-7.30 (m, 4H), 7.29 (d, J = 4.6 Hz, 1H), 
               
               
                   
                 7.24 (d, J = 2.3 Hz, 1H), 6.04 (s, 1H), 4.79 (p, J = 6.6 Hz, 1H), 4.58 (s, 2H), 1.52 (dd, J = 6.7, 
               
               
                   
                 1.7 Hz, 6H) 
               
               
                 719 
                 1H NMR (400 MHz, Methanol-d4) δ 8.47 (s, 1H), 8.29 (s, 1H), 7.68 (d, J = 2.6 Hz, 
               
               
                   
                 1H), 7.57-7.39 (m, 4H), 7.35 (dd, J = 6.4, 2.7 Hz, 1H), 7.27 (t, J = 8.8 Hz, 1H), 
               
               
                   
                 7.20 (d, J = 2.4 Hz, 1H), 7.19-7.12 (m, 1H), 6.38 (s, 1H), 4.90 (m, 1H), 4.79 (d, J = 13.5 Hz, 
               
               
                   
                 1H), 4.57 (d, J = 13.5 Hz, 1H), 3.94 (br s, 4H), 3.81 (d, J = 12.7 Hz, 2H), 3.22 (m, 
               
               
                   
                 2H), 2.46 (m, 4H), 1.47 (s, 9H) 
               
               
                 720 
                 1H NMR (400 MHz, Methanol-d4) δ 8.46 (s, 1H), 8.19 (s, 1H), 7.66 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.55 (d, J = 7.3 Hz, 1H), 7.52-7.42 (m, 3H), 7.37 (dd, J = 6.4, 2.6 Hz, 1H), 
               
               
                   
                 7.28 (t, J = 8.8 Hz, 1H), 7.22 (d, J = 2.4 Hz, 1H), 7.18 (m, 1H), 6.33 (s, 1H), 4.84-4.75 (m, 
               
               
                   
                 1H), 4.69 (d, J = 13.5 Hz, 1H), 4.55 (d, J = 13.6 Hz, 1H), 3.79 (d, J = 12.6 Hz, 2H), 
               
               
                   
                 3.22 (t, J = 12.7 Hz, 2H), 2.93 (s, 6H), 2.53-2.34 (m, 4H), 1.46 (s, 9H) 
               
               
                 721 
                 1H NMR (400 MHz, DMSO-d6) δ 9.59 (s, 1H), 9.17 (d, J = 2.5 Hz, 1H), 8.81 (d, J = 1.3 Hz, 
               
               
                   
                 1H), 8.72 (dt, J = 4.8, 1.3 Hz, 1H), 8.47 (d, J = 1.2 Hz, 1H), 8.36 (ddt, J = 8.4, 
               
               
                   
                 2.7, 1.4 Hz, 1H), 7.79-7.75 (m, 1H), 7.67 (dd, J = 8.3, 4.7 Hz, 1H), 7.60-7.51 (m, 
               
               
                   
                 3H), 7.47 (td, J = 9.0, 1.3 Hz, 1H), 7.43-7.37 (m, 2H), 7.32 (ddd, J = 12.6, 7.5, 3.9 Hz, 
               
               
                   
                 3H), 6.24 (d, J = 4.1 Hz, 1H). 
               
               
                 722 
                 1H NMR (400 MHz, Methanol-d4) δ 8.42 (s, 1H), 7.77 (s, 1H), 7.67 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.57-7.47 (m, 2H), 7.43-7.26 (m, 6H), 6.40 (s, 1H), 4.94 (d, J = 11.7 Hz, 1H), 
               
               
                   
                 4.85-4.72 (m, 1H), 4.59 (d, J = 11.8 Hz, 1H), 3.80 (d, J = 12.7 Hz, 2H), 3.22 (m, 2H), 
               
               
                   
                 2.43 (m, 4H), 1.46 (s, 9H) 
               
               
                 723 
                 1H NMR (400 MHz, DMSO-d6) δ 9.44 (s, 1H), 8.80 (s, 1H), 8.45-8.35 (m, 1H), 
               
               
                   
                 8.04 (s, 1H), 7.68 (d, J = 2.3 Hz, 1H), 7.53-7.26 (m, 7H), 7.27-7.03 (m, 2H), 6.53 (d, J = 4.1 Hz, 
               
               
                   
                 1H), 6.10 (d, J = 8.1 Hz, 1H), 4.95 (s, 1H), 4.75 (d, J = 6.7 Hz, 5H), 3.54 (s, 
               
               
                   
                 1H), 3.00 (s, 1H), 2.59-2.49 (m, 1H), 2.34 (d, J = 7.6 Hz, 2H), 2.20 (s, 2H) 
               
               
                 724 
                 1H NMR (400 MHz, DMSO-d6) δ 9.49 (s, 1H), 8.42 (s, 1H), 7.91 (d, J = 0.4 Hz, 1H), 
               
               
                   
                 7.69 (d, J = 2.2 Hz, 1H), 7.54-7.43 (m, 3H), 7.43-7.35 (m, 3H), 7.27 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.15-7.06 (m, 1H), 6.11 (d, J = 5.6 Hz, 1H), 4.53-4.46 (m, 2H), 3.77 (dd, J = 5.7, 
               
               
                   
                 4.8 Hz, 2H), 3.49-3.42 (m, 2H), 3.35-3.28 (m, 2H), 3.24-3.01 (m, 4H) 
               
               
                 726 
                 1H NMR (400 MHz, Methanol-d4) δ 8.41 (s, 1H), 8.07 (s, 1H), 7.75 (s, 1H), 
               
               
                   
                 7.66-7.49 (m, 4H), 7.37 (dd, J = 6.4, 2.7 Hz, 1H), 7.28 (t, J = 8.8 Hz, 1H), 7.22-7.14 (m, 
               
               
                   
                 2H), 6.12 (s, 1H), 4.82 (m, 1H), 4.63 (s, 2H), 3.80 (d, J = 12.6 Hz, 2H), 3.68 (dd, J = 10.4, 
               
               
                   
                 5.4 Hz, 2H), 3.56 (dd, J = 10.1, 5.5 Hz, 2H), 3.23 (t, J = 12.2 Hz, 2H), 3.10 (d, J = 7.3 Hz, 
               
               
                   
                 6H), 2.56-2.28 (m, 4H), 1.47 (s, 9H) 
               
               
                 727 
                 1H NMR (400 MHz, Methanol-d4) δ 8.39 (s, 1H), 7.79 (s, 1H), 7.67-7.59 (m, 2H), 
               
               
                   
                 7.41 (m, 2H), 7.37-7.18 (m, 4H), 7.14 (d, J = 2.4 Hz, 1H), 6.01 (s, 1H), 
               
               
                   
                 4.97-4.70 (m, 1H), 3.80 (d, J = 12.4 Hz, 2H), 3.29-3.16 (m, 2H), 2.56-2.26 (m, 4H), 1.46 (s, 
               
               
                   
                 6H), 1.46 (s, 9H) 
               
               
                 728 
                 1H NMR (400 MHz, Methanol-d4) δ 8.41 (s, 1H), 8.12 (s, 1H), 7.96 (d, J = 7.9 Hz, 
               
               
                   
                 1H), 7.83 (s, 1H), 7.69 (d, J = 7.7 Hz, 1H), 7.64 (d, J = 2.4 Hz, 1H), 7.49 (t, J = 7.8 Hz, 
               
               
                   
                 1H), 7.39 (dd, J = 6.4, 2.6 Hz, 1H), 7.28 (t, J = 8.8 Hz, 1H), 7.24-7.13 (m, 1H), 
               
               
                   
                 7.11 (d, J = 2.4 Hz, 1H), 6.08 (s, 1H), 4.79-4.71 (m, 1H), 3.86 (s, 3H), 3.80 (d, J = 12.9 Hz, 
               
               
                   
                 2H), 3.20 (m, 2H), 2.60-2.27 (m, 4H), 1.46 (s, 9H) 
               
               
                 729 
                 1H NMR (400 MHz, DMSO-d6) δ 9.53 (s, 1H), 8.55 (ddd, J = 4.9, 1.8, 0.9 Hz, 1H), 
               
               
                   
                 8.45 (s, 1H), 8.06 (s, 1H), 7.83 (td, J = 7.7, 1.8 Hz, 1H), 7.72 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.54 (dd, J = 6.6, 2.6 Hz, 1H), 7.52-7.45 (m, 3H), 7.41-7.34 (m, 3H), 7.33 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.32-7.25 (m, 3H), 6.15 (s, 1H), 5.72 (s, 2H). 
               
               
                 731 
                 1H NMR (400 MHz, DMSO-d6) δ 9.49 (s, 1H), 9.02 (s, 1H), 8.78 (s, 1H), 8.46 (s, 
               
               
                   
                 1H), 8.02 (s, 1H), 7.70 (s, 1H), 7.66-7.59 (m, 1H), 7.59-7.52 (m, 1H), 
               
               
                   
                 7.52-7.45 (m, 3H), 7.44-7.37 (m, 3H), 7.35 (d, J = 1.8 Hz, 1H), 7.33-7.29 (m, 1H), 7.27 (s, 
               
               
                   
                 1H), 7.18 (dd, J = 6.7, 2.9 Hz, 1H), 6.52 (d, J = 4.1 Hz, 1H), 6.11 (d, J = 8.1 Hz, 1H), 
               
               
                   
                 4.95 (s, 1H), 4.85-4.74 (m, 1H), 3.65 (d, J = 11.9 Hz, 2H), 3.12 (q, J = 11.3 Hz, 2H), 
               
               
                   
                 2.39-2.30 (m, 2H), 2.24 (t, J = 13.2 Hz, 2H), 1.35 (s, 9H), 1.29 (s, 1H) 
               
               
                 732 
                 1H NMR (400 MHz, DMSO-d6) δ 9.42 (s, 1H), 8.99 (s, 1H), 8.40 (d, J = 17.2 Hz, 1H), 
               
               
                   
                 8.00 (s, 1H), 7.68 (d, J = 2.2 Hz, 1H), 7.52-7.28 (m, 7H), 7.25-7.15 (m, 1H), 7.07 (d, 
               
               
                   
                 J = 8.8 Hz, 1H), 6.52 (d, J = 4.1 Hz, 1H), 6.09 (d, J = 8.2 Hz, 1H), 4.91 (s, 1H), 
               
               
                   
                 4.85-4.74 (m, 1H), 3.65 (d, J = 12.2 Hz, 2H), 3.12 (q, J = 11.4 Hz, 2H), 2.39-2.30 (m, 2H), 
               
               
                   
                 2.24 (t, J = 13.2 Hz, 2H), 1.35 (s, 9H) 
               
               
                 733 
                 1H NMR (400 MHz, Methanol-d4) δ 8.45 (s, 1H), 7.98 (s, 1H), 7.67 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.66 (s, 1H), 7.56 (d, J = 7.7 Hz, 1H), 7.49 (t, J = 7.6 Hz, 1H), 7.44 (dd, J = 6.6, 
               
               
                   
                 2.4 Hz, 2H), 7.32 (t, J = 8.8 Hz, 1H), 7.28-7.21 (m, 1H), 7.19 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 6.08 (s, 1H), 4.83-4.76 (m, 1H), 4.33 (q, J = 12.9 Hz, 2H), 3.93 (br s, 2H), 3.80 (d, J = 12.6 Hz, 
               
               
                   
                 2H), 3.64 (br s, 2H), 3.28-3.17 (m, 6H), 2.46 (m, 4H), 1.46 (s, 9H) 
               
               
                 735 
                 1H NMR (400 MHz, Methanol-d4) δ 8.42 (s, 1H), 7.97 (s, 1H), 7.64 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.59 (d, J = 8.0 Hz, 2H), 7.49 (d, J = 8.1 Hz, 2H), 7.42 (dd, J = 6.5, 2.6 Hz, 1H), 
               
               
                   
                 7.30 (t, J = 8.8 Hz, 1H), 7.23 (m, 1H), 7.17 (d, J = 2.4 Hz, 1H), 6.09 (s, 1H), 4.80 (m, 
               
               
                   
                 1H), 4.29 (s, 2H), 3.79 (d, J = 12.3 Hz, 2H), 3.27-3.16 (m, 2H), 2.82 (s, 6H), 2.45 (m, 
               
               
                   
                 4H), 1.46 (s, 9H) 
               
               
                 737 
                 1H NMR (400 MHz, DMSO-d6) δ 9.40 (s, 1H), 8.37 (s, 1H), 7.88 (s, 1H), 7.67 (s, 
               
               
                   
                 1H), 7.45 (d, J = 9.2 Hz, 1H), 7.44-7.39 (m, 2H), 7.36 (d, J = 8.8 Hz, 1H), 7.31 (t, J = 7.6 Hz, 
               
               
                   
                 2H), 7.27-7.19 (m, 3H), 6.06 (d, J = 8.7 Hz, 1H), 4.42 (t, J = 6.3 Hz, 2H), 
               
               
                   
                 3.42 (t, J = 4.6 Hz, 4H), 2.72-2.60 (m, 2H), 2.31 (dd, J = 6.1, 3.3 Hz, 4H). 
               
               
                 738 
                 1H NMR (400 MHz, DMSO-d6) δ 9.39 (s, 1H), 8.37 (s, 1H), 7.88 (s, 1H), 7.67 (s, 
               
               
                   
                 1H), 7.50-7.35 (m, 4H), 7.34-7.27 (m, 2H), 7.27-7.18 (m, 3H), 6.07 (d, J = 8.9 Hz, 
               
               
                   
                 1H), 4.99 (t, J = 5.2 Hz, 1H), 4.35 (t, J = 5.4 Hz, 2H), 3.72 (q, J = 5.3 Hz, 2H). 
               
               
                 746 
                 1H NMR (400 MHz, DMSO-d6) δ 9.54 (s, 1H), 8.40 (s, 1H), 7.80 (s, 1H), 7.70 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.52 (dd, J = 6.6, 2.6 Hz, 1H), 7.48-7.40 (m, 3H), 7.37-7.29 (m, 3H), 
               
               
                   
                 7.29-7.20 (m, 2H), 6.11 (s, 1H), 5.41 (d, J = 1.6 Hz, 2H), 3.57 (dt, J = 21.9, 4.6 Hz, 
               
               
                   
                 4H), 3.43 (dt, J = 22.7, 4.8 Hz, 4H). 
               
               
                 748 
                 1H NMR (400 MHz, DMSO-d6) δ 9.44 (s, 1H), 8.39 (s, 1H), 8.14 (m, 1H), 7.67 (m, 
               
               
                   
                 1H), 7.51-7.08 (m, 10H), 6.09 (m, 1H), 5.01 (m, 1H), 3.76 (m, 1H), 3.64 (m, 1H), 
               
               
                   
                 3.50 (m, 2H), 2.73 (m, 2H). 
               
               
                 749 
                 1H NMR (400 MHz, DMSO-d6) δ 8.98 (s, 1H), 8.86 (s, 1H), 7.95 (s, 1H), 7.80 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.66 (d, J = 6.5 Hz, 1H), 7.39-7.26 (m, 4H), 7.14 (t, J = 9.0 Hz, 1H), 
               
               
                   
                 6.82 (dd, J = 6.1, 3.0 Hz, 1H), 6.44 (dt, J = 9.1, 3.4 Hz, 1H), 6.38 (s, 1H), 5.79 (d, J = 6.3 Hz, 
               
               
                   
                 1H), 4.87 (s, 1H), 4.82-4.71 (m, 1H), 3.65 (d, J = 12.1 Hz, 2H), 3.40 (s, 1H), 
               
               
                   
                 3.24 (s, 3H), 3.11 (q, J = 11.5 Hz, 2H), 2.33 (d, J = 13.1 Hz, 2H), 2.21 (q, J = 12.5 Hz, 
               
               
                   
                 2H), 1.35 (s, 9H) 
               
               
                 750 
                 1H NMR (400 MHz, DMSO-d6) δ 9.74 (s, 1H), 8.98 (s, 1H), 8.63 (d, J = 19.1 Hz, 1H), 
               
               
                   
                 8.55 (d, J = 2.6 Hz, 1H), 8.39 (d, J = 2.7 Hz, 1H), 7.98 (s, 1H), 7.82-7.72 (m, 2H), 
               
               
                   
                 7.61-7.49 (m, 2H), 7.48-7.38 (m, 2H), 7.38-7.28 (m, 2H), 7.05 (s, 1H), 6.52 (d, J = 3.9 Hz, 
               
               
                   
                 1H), 6.30 (d, J = 8.1 Hz, 1H), 5.97 (d, J = 7.5 Hz, 1H), 4.83-4.72 (m, 1H), 
               
               
                   
                 3.64 (d, J = 11.7 Hz, 2H), 3.10 (d, J = 11.8 Hz, 2H), 2.31 (s, 3H), 2.21 (d, J = 12.8 Hz, 
               
               
                   
                 1H), 1.35 (s, 9H), 1.30 (s, 1H) 
               
               
                 751 
                 1H NMR (400 MHz, DMSO-d6) δ 9.47 (s, 1H), 9.00 (s, 1H), 8.77 (s, 1H), 
               
               
                   
                 8.41-8.33 (m, 1H), 8.03 (s, 1H), 7.76 (s, 1H), 7.67 (s, 1H), 7.55-7.47 (m, 2H), 7.47-7.28 (m, 
               
               
                   
                 8H), 7.18 (dd, J = 6.7, 2.9 Hz, 1H), 6.52 (d, J = 4.1 Hz, 1H), 6.17 (d, J = 8.7 Hz, 1H), 
               
               
                   
                 4.95 (s, 1H), 4.86-4.75 (m, 1H), 3.85 (s, 3H), 3.66 (d, J = 12.1 Hz, 2H), 3.12 (d, J = 11.8 Hz, 
               
               
                   
                 2H), 2.36 (d, J = 13.3 Hz, 3H), 2.26 (t, J = 12.2 Hz, 2H), 1.35 (s, 9H), 1.30 (s, 
               
               
                   
                 1H) 
               
               
                 752 
                 1H NMR (400 MHz, DMSO-d6) δ 9.44 (s, 1H), 9.03 (d, J = 7.7 Hz, 1H), 8.34 (s, 1H), 
               
               
                   
                 8.02 (s, 1H), 7.92 (d, J = 2.4 Hz, 1H), 7.67 (d, J = 2.2 Hz, 1H), 7.61-7.55 (m, 1H), 
               
               
                   
                 7.54-7.48 (m, 2H), 7.46-7.39 (m, 2H), 7.40-7.33 (m, 2H), 7.32 (d, J = 2.7 Hz, 1H), 
               
               
                   
                 7.18 (d, J = 6.0 Hz, 1H), 6.37 (d, J = 2.4 Hz, 1H), 6.19 (d, J = 8.5 Hz, 1H), 5.12 (q, J = 9.0 Hz, 
               
               
                   
                 2H), 4.86-4.75 (m, 1H), 3.66 (d, J = 12.2 Hz, 2H), 3.12 (q, J = 11.2 Hz, 2H), 
               
               
                   
                 2.37 (d, J = 14.1 Hz, 3H), 2.24 (q, J = 12.7 Hz, 2H), 1.35 (s, 9H), 1.28 (s, 1H) 
               
               
                 753 
                 1H NMR (400 MHz, DMSO-d6) δ 9.50 (s, 1H), 9.00 (s, 1H), 8.53 (s, 1H), 
               
               
                   
                 8.41-8.35 (m, 0H), 7.98 (s, 1H), 7.71 (d, J = 2.3 Hz, 1H), 7.59-7.51 (m, 2H), 7.47 (s, 1H), 
               
               
                   
                 7.47-7.41 (m, 3H), 7.40-7.34 (m, 2H), 7.33-7.29 (m, 1H), 7.24-7.15 (1, 0H), 7.10 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 6.52 (d, J = 4.0 Hz, 1H), 6.00 (d, J = 7.8 Hz, 1H), 4.95 (s, 1H), 4.90 (s, 
               
               
                   
                 1H), 4.83-4.73 (m, 1H), 3.65 (d, J = 11.8 Hz, 2H), 3.11 (q, J = 11.4 Hz, 2H), 2.33 (d, 
               
               
                   
                 J = 12.6 Hz, 2H), 2.23 (t, J = 12.6 Hz, 2H), 1.35 (s, 9H) 
               
               
                 759 
                 1H NMR (400 MHz, DMSO-d6) δ 9.41 (s, 1H), 8.96 (s, 1H), 8.44 (s, 1H), 7.99 (s, 
               
               
                   
                 1H), 7.68 (d, J = 2.2 Hz, 1H), 7.50-7.42 (m, 3H), 7.42-7.33 (m, 4H), 7.33-7.25 (m, 
               
               
                   
                 2H), 7.19 (d, J = 2.4 Hz, 1H), 6.03 (d, J = 8.1 Hz, 1H), 4.84-4.73 (m, 1H), 3.65 (d, J = 12.1 Hz, 
               
               
                   
                 2H), 3.11 (q, J = 11.4 Hz, 2H), 2.38-2.30 (m, 2H), 2.24 (t, J = 12.8 Hz, 2H), 
               
               
                   
                 1.35 (s, 9H) 
               
               
                 760 
                 1H NMR (400 MHz, DMSO-d6) δ 8.98 (s, 1H), 7.99 (s, 1H), 7.45-7.17 (m, 9H), 
               
               
                   
                 7.01 (dt, J = 7.9, 3.4 Hz, 1H), 6.92-6.87 (m, 1H), 6.64 (d, J = 8.1 Hz, 1H), 6.12-6.06 (m, 
               
               
                   
                 1H), 5.80 (d, J = 8.0 Hz, 1H), 4.37 (m, 1H), 3.10-2.99 (m, 2H), 2.88-2.78 (m, 1H), 
               
               
                   
                 2.18 (m, 2H), 2.04-1.91 (m, 2H), 1.85 (m, 2H), 1.02 (s, 9H) 
               
               
                 761 
                 1H NMR (400 MHz, DMSO-d6) δ 9.48 (s, 1H), 9.11 (s, 1H), 8.48 (s, 1H), 7.99 (s, 
               
               
                   
                 1H), 7.69 (d, J = 2.3 Hz, 1H), 7.55-7.27 (m, 9H), 7.18 (d, J = 2.6 Hz, 1H), 7.05 (s, 
               
               
                   
                 1H), 6.91 (s, 1H), 6.53 (d, J = 4.0 Hz, 1H), 6.01 (d, J = 7.3 Hz, 1H), 4.87-4.64 (m, 
               
               
                   
                 1H), 3.65 (d, J = 12.1 Hz, 2H), 3.11 (d, J = 11.9 Hz, 1H), 2.40-2.13 (m, 3H), 1.35 (s, 
               
               
                   
                 9H) 
               
               
                 762 
                 1H NMR (400 MHz, DMSO-d6) δ 9.53 (s, 1H), 9.00 (s, 1H), 8.51 (s, 1H), 7.99 (s, 
               
               
                   
                 1H), 7.71 (d, J = 2.2 Hz, 1H), 7.57 (td, J = 8.1, 0.8 Hz, 1H), 7.51-7.29 (m, 7H), 
               
               
                   
                 7.15 (d, J = 2.4 Hz, 1H), 6.01 (d, J = 7.8 Hz, 1H), 4.84-4.73 (m, 1H), 3.65 (d, J = 11.9 Hz, 
               
               
                   
                 2H), 3.11 (q, J = 11.3 Hz, 2H), 2.34 (d, J = 12.4 Hz, 2H), 2.22 (q, J = 12.9 Hz, 2H), 
               
               
                   
                 1.35 (s, 9H) 
               
               
                 766 
                 1H NMR (400 MHz, DMSO-d6) δ 9.41 (s, 1H), 9.10 (s, 1H), 8.37 (d, J = 13.0 Hz, 1H), 
               
               
                   
                 8.02 (s, 1H), 7.66 (d, J = 2.2 Hz, 1H), 7.54-7.45 (m, 2H), 7.45-7.36 (m, 2H), 
               
               
                   
                 7.36-7.20 (m, 4H), 6.13 (d, J = 8.1 Hz, 1H), 4.88-4.71 (m, 1H), 3.66 (d, J = 12.2 Hz, 2H), 
               
               
                   
                 3.13 (t, J = 11.5 Hz, 2H), 2.43-2.30 (m, 2H), 2.26 (t, J = 12.8 Hz, 2H), 1.36 (s, 9H) 
               
               
                 767 
                 1H NMR (400 MHz, DMSO-d6) δ 9.43 (s, 1H), 8.77 (d, J = 7.8 Hz, 1H), 8.48 (s, 1H), 
               
               
                   
                 8.38 (d, J = 0.9 Hz, 1H), 7.99 (s, 1H), 7.69 (d, J = 2.3 Hz, 1H), 7.49-7.27 (m, 6H), 
               
               
                   
                 7.22-7.12 (m, 1H), 7.05-6.90 (m, 2H), 6.52 (d, J = 4.1 Hz, 1H), 6.03 (d, J = 7.8 Hz, 
               
               
                   
                 1H), 4.95 (s, 1H), 4.87-4.70 (m, 1H), 3.65 (d, J = 12.2 Hz, 2H), 3.11 (q, J = 11.2 Hz, 
               
               
                   
                 2H), 2.34 (d, J = 11.0 Hz, 2H), 2.24 (t, J = 12.9 Hz, 1H), 1.41-1.27 (m, 9H) 
               
               
                 768 
                 1H NMR (400 MHz, DMSO-d6) δ 9.33 (s, 1H), 9.05 (d, J = 8.2 Hz, 1H), 8.79 (s, 1H), 
               
               
                   
                 8.43-8.34 (m, 1H), 8.02 (s, 1H), 7.67 (d, J = 2.2 Hz, 1H), 7.56-7.46 (m, 1H), 
               
               
                   
                 7.46-7.23 (m, 11H), 7.22-7.14 (m, 1H), 6.53 (d, J = 4.1 Hz, 0H), 6.15 (d, J = 8.5 Hz, 1H), 
               
               
                   
                 4.95 (s, 1H), 4.86-4.75 (m, 1H), 3.67 (s, 1H), 3.19-3.04 (m, 2H), 2.36 (d, J = 13.8 Hz, 
               
               
                   
                 2H), 2.24 (q, J = 12.2, 11.6 Hz, 1H), 1.35 (s, 9H) 
               
               
                 769 
                 1H NMR (400 MHz, DMSO-d6) δ 9.15 (s, 1H), 8.42 (s, 1H), 8.10 (s, 1H), 
               
               
                   
                 7.47-7.25 (m, 7H), 7.14-7.04 (m, 2H), 6.26 (d, J = 8.0 Hz, 1H), 5.99 (d, J = 7.9 Hz, 1H), 
               
               
                   
                 4.50-4.40 (m, 1H), 4.04 (s, 3H), 2.06 (m, 3H), 1.96-1.89 (m, 5H), 1.09 (s, 9H) 
               
               
                 773 
                 1H NMR (400 MHz, DMSO-d6) δ 10.72 (s, 1H), 8.87 (s, 1H), 7.93 (s, 1H), 7.82 (dd, J = 6.6, 
               
               
                   
                 2.5 Hz, 1H), 7.69 (s, 1H), 7.64-7.44 (m, 5H), 7.24-7.10 (m, 2H), 6.60 (d, J = 8.7 Hz, 
               
               
                   
                 1H), 6.33 (d, J = 8.2 Hz, 1H), 4.02 (s, 3H), 2.50 (s, 3H) 
               
               
                 774 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) δ 8.38 (d, J = 0.7 Hz, 1H), 7.97 (s, 
               
               
                   
                 1H), 7.64 (d, J = 2.3 Hz, 1H), 7.47-7.36 (m, 5H), 7.30 (t, J = 7.6 Hz, 3H), 
               
               
                   
                 7.26-7.17 (m, 4H), 6.02 (s, 1H), 5.01 (p, J = 8.2 Hz, 1H), 4.27-4.19 (m, 1H), 4.18-3.94 (m, 
               
               
                   
                 5H), 3.09 (q, J = 7.2 Hz, 3H), 2.85 (dt, J = 12.3, 6.1 Hz, 1H), 2.81-2.71 (m, 2H), 
               
               
                   
                 2.65 (ddt, J = 12.5, 8.2, 4.6 Hz, 2H), 1.01 (t, J = 7.2 Hz, 3H) 
               
               
                 775 
                 1H NMR (400 MHz, DMSO-d6) δ 9.40 (s, 1H), 8.57 (s, 2H), 8.39 (s, 1H), 7.99 (s, 
               
               
                   
                 1H), 7.66 (d, J = 2.2 Hz, 1H), 7.45 (dd, J = 6.6, 2.6 Hz, 1H), 7.44-7.37 (m, 3H), 
               
               
                   
                 7.31 (dd, J = 8.3, 6.8 Hz, 3H), 7.26-7.18 (m, 3H), 6.04 (d, J = 6.8 Hz, 1H), 5.00 (p, J = 8.2 Hz, 
               
               
                   
                 1H), 4.05 (t, J = 6.2 Hz, 2H), 3.95 (t, J = 6.2 Hz, 2H), 2.85-2.74 (m, 2H), 2.67 (tq, 
               
               
                   
                 J = 8.4, 5.0, 4.0 Hz, 2H). 
               
               
                 776 
                 1H NMR (400 MHz, DMSO-d6) δ 9.40 (s, 1H), 8.95 (s, 1H), 8.49 (s, 1H), 7.98 (s, 
               
               
                   
                 1H), 7.69 (d, J = 2.3 Hz, 1H), 7.49-7.32 (m, 7H), 7.24-7.16 (m, 2H), 7.14 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.11-7.06 (m, 1H), 6.01 (d, J = 7.9 Hz, 1H), 4.76 (d, J = 11.8 Hz, 1H), 
               
               
                   
                 3.65 (d, J = 12.2 Hz, 2H), 3.11 (q, J = 11.4 Hz, 2H), 2.34 (d, J = 12.4 Hz, 2H), 2.22 (d, J = 13.0 Hz, 
               
               
                   
                 2H), 1.35 (s, 9H) 
               
               
                 778 
                 1H NMR (400 MHz, DMSO-d6) δ 9.43 (s, 1H), 8.65 (s, 1H), 8.41 (s, 2H), 7.98 (s, 
               
               
                   
                 1H), 7.68 (d, J = 2.2 Hz, 1H), 7.54-7.13 (m, 9H), 6.07 (d, J = 7.9 Hz, 1H), 
               
               
                   
                 4.84-4.69 (m, 1H), 3.39 (d, J = 13.0 Hz, 2H), 3.06 (d, J = 11.7 Hz, 2H), 2.31-2.00 (m, 4H) 
               
               
                 780 
                 1H NMR (400 MHz, DMSO-d6) δ 9.55 (s, 1H), 8.98 (s, 1H), 8.77 (s, 1H), 8.53 (s, 
               
               
                   
                 1H), 8.43-8.35 (m, 2H), 7.96 (s, 1H), 7.76-7.65 (m, 2H), 7.51-7.10 (m, 7H), 
               
               
                   
                 5.99 (d, J = 7.7 Hz, 1H), 4.78 (t, J = 11.9 Hz, 1H), 3.64 (d, J = 11.7 Hz, 2H), 3.08 (dd, J = 23.6, 
               
               
                   
                 12.4 Hz, 2H), 2.33 (d, J = 13.2 Hz, 2H), 2.21 (d, J = 13.0 Hz, 3H), 1.35 (s, 9H) 
               
               
                 781 
                 1H NMR (400 MHz, DMSO-d6) δ 9.50 (s, 2H), 8.44 (s, 1H), 8.04 (s, 1H), 7.72 (d, J = 2.3 Hz, 
               
               
                   
                 2H), 7.55 (d, J = 8.4 Hz, 1H), 7.51-7.44 (m, 4H), 7.44-7.21 (m, 9H), 
               
               
                   
                 6.15-6.00 (m, 1H), 4.79 (s, 1H), 4.38 (s, 1H), 3.41-3.27 (m, 19H), 3.31-3.24 (m, 1H), 
               
               
                   
                 3.03 (s, 3H), 2.15 (s, 2H), 1.97 (s, 2H), 1.91 (s, 1H), 1.02 (s, 9H) 
               
               
                 785 
                 1H NMR (400 MHz, DMSO-d6) δ 9.57 (s, 1H), 8.97 (s, 1H), 8.78 (s, 1H), 8.51 (s, 
               
               
                   
                 1H), 8.42-8.35 (m, 1H), 8.21-8.02 (m, 2H), 7.95 (s, 1H), 7.85-7.77 (m, 2H), 
               
               
                   
                 7.72 (d, J = 2.3 Hz, 1H), 7.58-7.48 (m, 1H), 7.46-7.12 (m, 8H), 6.72 (s, 1H), 6.52 (d, J = 4.1 Hz, 
               
               
                   
                 1H), 5.98 (d, J = 7.4 Hz, 1H), 5.89 (s, 1H), 4.95 (s, 1H), 4.82-4.71 (m, 1H), 
               
               
                   
                 3.61 (d, J = 12.1 Hz, 2H), 3.08 (q, J = 12.0 Hz, 2H), 2.31 (d, J = 14.4 Hz, 2H), 2.21 (t, 
               
               
                   
                 J = 13.2 Hz, 2H), 1.34 (s, 9H) 
               
               
                 786 
                 1H NMR (400 MHz, DMSO-d6) δ 9.41 (s, 1H), 9.04 (s, 1H), 8.62 (d, J = 4.7 Hz, 1H), 
               
               
                   
                 8.35 (s, 1H), 7.98 (s, 1H), 7.90 (td, J = 7.7, 1.8 Hz, 1H), 7.72-7.57 (m, 2H), 
               
               
                   
                 7.55-7.18 (m, 8H), 6.12 (d, J = 7.0 Hz, 1H), 5.32 (s, 2H), 4.85-4.74 (m, 1H), 3.65 (d, J = 11.9 Hz, 
               
               
                   
                 2H), 3.11 (q, J = 10.0, 8.8 Hz, 1H), 2.54 (s, 1H), 2.39-2.30 (m, 2H), 2.23 (q, 
               
               
                   
                 J = 12.0, 11.1 Hz, 2H), 1.40-1.27 (m, 9H) 
               
               
                 787 
                 1H NMR (400 MHz, DMSO-d6) δ 9.45 (s, 1H), 8.99 (s, 1H), 8.42 (s, 1H), 7.97 (s, 
               
               
                   
                 1H), 7.69 (d, J = 2.2 Hz, 1H), 7.52-7.21 (m, 9H), 7.07 (d, J = 9.0 Hz, 1H), 6.08 (d, J = 7.8 Hz, 
               
               
                   
                 1H), 4.85-4.74 (m, 1H), 3.65 (d, J = 12.0 Hz, 2H), 3.52 (s, 1H), 3.11 (q, J = 11.7 Hz, 
               
               
                   
                 2H), 2.57-2.47 (m, 10H), 2.35 (d, J = 12.8 Hz, 2H), 2.22 (q, J = 13.4 Hz, 
               
               
                   
                 2H), 1.35 (s, 9H) 
               
               
                 789 
                 1H NMR (400 MHz, DMSO-d6) δ 9.39 (s, 1H), 8.77 (m, 1H), 8.48 (m, 1H), 8.39 (s, 
               
               
                   
                 1H), 7.93 (s, 1H), 7.66 (m, 1H) 7.49-7.15 (m, 9H), 6.04 (m, 1H), 4.92 (m, 1H), 
               
               
                   
                 3.24 (m, 2H), 2.17 (m, 2H), 2.01 (m, 2H), 1.34 (s, 3H), 1.32 (s, 3H). 
               
               
                 790 
                 1H NMR (400 MHz, DMSO-d6) δ 9.40 (s, 1H), 8.88 (m, 1H), 8.49 (m, 1H), 8.39 (s, 
               
               
                   
                 1H), 7.93 (s, 1H), 7.67 (s, 1H) 7.49-7.15 (m, 11H), 6.04 (m, 1H), 4.91 (m, 1H), 
               
               
                   
                 3.27 (m, 2H), 2.17 (m, 2H), 2.01 (m, 2H), 1.34 (s, 3H), 1.32 (s, 3H). 
               
               
                 791 
                 1H NMR (400 MHz, DMSO-d6) δ 9.48 (s, 1H), 9.42 (brs, 1H), 8.34 (s, 1H), 8.05 (s, 
               
               
                   
                 1H), 7.44-7.30 (m, 5H), 7.25-7.15 (m, 6H), 7.10 (s, 1H) 6.06 (s, 1H), 4.73 (m, 1H), 
               
               
                   
                 3.60 (d, J = 12.0 Hz, 2H), 3.24-3.04 (m, 4H), 2.32 (m, 2H), 2.17 (m, 2H), 1.20 (m, 
               
               
                   
                 3H). 
               
               
                 792 
                 1H NMR (400 MHz, DMSO-d6) δ 9.43-9.32 (m, 1H), 8.39 (s, 1H), 8.01 (s, 1H), 
               
               
                   
                 7.68 (d, J = 2.3 Hz, 1H), 7.50-7.16 (m, 8H), 6.03 (d, J = 8.5 Hz, 1H), 4.49-4.33 (m, 2H), 
               
               
                   
                 2.96-2.81 (m, 2H), 2.31-2.23 (m, 2H), 2.06-1.83 (m, 5H), 1.46-1.21 (m, 5H), 
               
               
                   
                 0.87 (t, J = 7.3 Hz, 3H) 
               
               
                 793 
                 1H NMR (400 MHz, DMSO-d6) δ 9.58 (s, 1H), 9.43 (s, 1H), 8.39 (s, 1H), 8.00 (s, 
               
               
                   
                 1H), 7.68 (d, J = 2.2 Hz, 1H), 7.48 (dd, J = 6.6, 2.6 Hz, 1H), 7.46-7.39 (m, 3H), 
               
               
                   
                 7.37 (d, J = 8.7 Hz, 1H), 7.33 (dd, J = 8.3, 6.8 Hz, 2H), 7.28-7.20 (m, 3H), 6.09 (d, J = 7.8 Hz, 
               
               
                   
                 1H), 4.74 (t, J = 6.5 Hz, 2H), 3.58 (q, J = 5.4 Hz, 2H), 2.78 (d, J = 3.7 Hz, 6H). 
               
               
                 794 
                 1H NMR (400 MHz, DMSO-d6) δ 9.42 (s, 1H), 8.64 (brs, 1H), 8.42 (brs, 1H), 8.32 (s, 
               
               
                   
                 1H), 7.97 (s, 1H), 7.49-7.15 (m, 11H), 7.08 (s, 1H) 6.05 (s, 1H), 4.75 (m, 1H), 
               
               
                   
                 3.38 (d, J = 12.0 Hz, 2H), 3.04 (m, 2H), 2.22 (m, 2H), 2.08 (m, 2H). 
               
               
                 795 
                 1H NMR (400 MHz, DMSO-d6) δ 9.50 (s, 1H), 8.40 (s, 1H), 7.87 (s, 1H), 7.68 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.50 (dd, J = 6.6, 2.6 Hz, 1H), 7.46-7.39 (m, 4H), 7.31 (t, J = 7.6 Hz, 
               
               
                   
                 2H), 7.28-7.20 (m, 3H), 6.08 (s, 1H), 4.48 (t, J = 5.2 Hz, 2H), 3.67 (dd, J = 5.6, 4.7 Hz, 
               
               
                   
                 2H), 3.17 (s, 3H). 
               
               
                 796 
                 1H NMR (400 MHz, DMSO-d6) δ 8.39 (s, 1H), 7.99 (s, 1H), 7.67 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 7.48 (dd, J = 6.6, 2.7 Hz, 1H), 7.46-7.39 (m, 3H), 7.31 (dd, J = 8.4, 6.8 Hz, 2H), 
               
               
                   
                 7.23 (ddt, J = 8.5, 4.5, 2.3 Hz, 3H), 6.08 (s, 1H), 4.54 (t, J = 6.2 Hz, 2H), 3.29 (t, J = 6.3 Hz, 
               
               
                   
                 2H). 
               
               
                 797 
                 1H NMR (400 MHz, DMSO-d6) δ 9.42 (s, 1H), 8.39 (s, 1H), 7.95 (s, 1H), 7.67 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.47 (dd, J = 6.6, 2.6 Hz, 1H), 7.45-7.39 (m, 3H), 7.38-7.29 (m, 3H), 
               
               
                   
                 7.27-7.19 (m, 3H), 6.06 (d, J = 7.2 Hz, 1H), 4.38 (t, J = 7.1 Hz, 2H), 3.10-3.00 (m, 
               
               
                   
                 2H), 2.74 (s, 3H), 2.73 (s, 3H), 2.21-2.10 (m, 2H). 
               
               
                 798 
                 1H NMR (400 MHz, DMSO-d6) δ 10.40 (s, 1H), 8.82 (s, 1H), 7.92 (s, 1H), 7.72 (dd, J = 6.6, 
               
               
                   
                 2.5 Hz, 1H), 7.57-7.34 (m, 5H), 7.29 (s, 1H), 7.21-7.08 (m, 2H), 6.73 (d, J = 9.0 Hz, 
               
               
                   
                 1H), 6.18 (d, J = 8.6 Hz, 1H), 4.05 (s, 3H), 3.98 (s, 3H) 
               
               
                 803 
                 1H NMR (400 MHz, DMSO-d6) δ 9.37 (s, 1H), 8.92 (s, 1H), 8.41 (s, 1H), 7.97 (s, 
               
               
                   
                 1H), 7.66 (d, J = 2.2 Hz, 1H), 7.48-7.42 (m, 3H), 7.39 (td, J = 5.9, 2.7 Hz, 4H), 
               
               
                   
                 7.24-7.20 (m, 1H), 7.19 (d, J = 2.5 Hz, 2H), 6.06 (d, J = 8.2 Hz, 1H), 4.77 (ddt, J = 11.7, 
               
               
                   
                 8.4, 4.6 Hz, 1H), 3.63 (d, J = 12.3 Hz, 3H), 3.10 (q, J = 11.6 Hz, 2H), 2.38-2.28 (m, 
               
               
                   
                 3H), 2.21 (d, J = 13.1 Hz, 2H), 1.33 (s, 9H). 
               
               
                 804 
                 1H NMR (400 MHz, DMSO-d6) δ 9.34 (s, 1H), 8.30 (s, 1H), 8.00 (s, 1H), 
               
               
                   
                 7.49-7.17 (m, 16 H), 7.05 (s, 1H), 6.02 (m, 1H), 5.07 (s, 2H), 4.69 (m, 1H), 4.06 (m 2H), 
               
               
                   
                 2.99 (m, 2H), 2.01 (m, 2H), 1.83 (m, 2H) 
               
               
                 808 
                 1H NMR (400 MHz, DMSO-d6) δ 9.41 (s, 1H), 8.39 (s, 1H), 7.93 (s, 1H), 7.66 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.52-7.39 (m, 5H), 7.34 (d, J = 9.8 Hz, 1H), 7.22 (tt, J = 6.3, 3.4 Hz, 
               
               
                   
                 2H), 7.19-7.12 (m, 2H), 6.06 (d, J = 4.0 Hz, 1H), 4.55 (s, 2H), 4.48 (dd, J = 6.0, 2.1 Hz, 
               
               
                   
                 2H), 4.17 (dd, J = 6.0, 2.1 Hz, 2H), 1.07 (s, 3H). 
               
               
                 810 
                 1H NMR (400 MHz, DMSO-d6) δ 9.36 (s, 1H), 8.38 (s, 1H), 8.14 (s, 1H), 7.65 (s, 
               
               
                   
                 1H), 7.47 (ddd, J = 9.1, 5.7, 2.9 Hz, 3H), 7.39 (q, J = 9.0 Hz, 2H), 7.21 (s, 2H), 
               
               
                   
                 7.18-7.10 (m, 2H), 6.09 (d, J = 8.6 Hz, 1H), 5.78 (tt, J = 7.5, 6.0 Hz, 1H), 5.00-4.92 (m, 
               
               
                   
                 2H), 4.84 (dt, J = 8.8, 6.6 Hz, 2H). 
               
               
                 812 
                 1H NMR (400 MHz, DMSO-d6) δ 9.45 (s, 1H), 8.40 (s, 1H), 8.04 (s, 1H), 7.67 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.51-7.39 (m, 4H), 7.36 (s, 1H), 7.24 (ddt, J = 8.9, 4.2, 2.1 Hz, 2H), 
               
               
                   
                 7.17-7.05 (m, 2H), 6.07 (s, 1H), 2.91 (s, 2H), 1.64 (d, J = 3.0 Hz, 6H). 
               
               
                 814 
                 1H NMR (400 MHz, DMSO-d6) δ 9.37 (s, 1H), 8.63 (brs, 1H), 8.35 (brs, 1H), 8.33 (s, 
               
               
                   
                 1H), 7.98 (s, 1H), 7.42 (m, 7H), 7.25 (m, 2H), 7.06 (m, 1H), 6.06 (m, 1H), 4.74 (m, 
               
               
                   
                 1H), 3.38 (m, 2H), 3.05 (m, 2H), 2.23 (m, 2H), 2.09 (m, 2H). 
               
               
                 815 
                 1H NMR (400 MHz, DMSO-d6) δ 9.47 (s, 1H), 8.41 (s, 1H), 8.08 (s, 1H), 7.66 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.51-7.45 (m, 4H), 7.42 (t, J = 9.0 Hz, 2H), 7.27 (d, J = 2.6 Hz, 1H), 
               
               
                   
                 7.26-7.22 (m, 1H), 7.20-7.12 (m, 2H), 6.13 (s, 1H), 5.74 (s, 2H). 
               
               
                 816 
                 1H NMR (400 MHz, DMSO-d6) δ 9.31 (s, 1H), 8.31 (s, 1H), 7.97 (s, 1H), 
               
               
                   
                 7.49-7.17 (m, 15 H), 7.03 (s, 1H), 6.03 (m, 1H), 5.07 (s, 2H), 4.69 (m, 1H), 4.06 (m 2H), 
               
               
                   
                 3.00 (m, 2H), 1.98 (m, 2H), 1.84 (m, 2H) 
               
               
                 818 
                 1H NMR (400 MHz, DMSO-d6) δ 9.41 (s, 1H), 8.39 (s, 1H), 7.66 (m, 2H), 7.45 (m, 
               
               
                   
                 5H), 7.19 (m, 4H), 6.07 (m, 1H), 4.30 (m, 3H), 3.09 (m, 1H), 2.92 (m, 1H), 2.60 (s, 
               
               
                   
                 6H), 1.80 (m, 1H), 1.53 (m, 2H), 1.38 (m, 1H). 
               
               
                 827 
                 1H NMR (400 MHz, DMSO-d6) δ 9.33 (brs, 1H), 8.59 (s, 1H), 8.05 (s, 1H), 7.74 (m, 
               
               
                   
                 1H), 7.50 (m, 5H), 7.31 (m, 2H), 7.15 (t, J = 8.0 Hz, 2H), 6.09 (s, 1H), 4.73 (m, 1H), 
               
               
                   
                 3.61 (m 2H), 3.15-3.02 (m, 4H), 2.33 (m, 2H), 2.15 (m, 2H), 1.20 (m, 3H). 
               
               
                 829 
                 1H NMR (400 MHz, DMSO-d6) δ 9.77 (s, 1H), 9.43-9.33 (m, 1H), 8.40 (s, 1H), 
               
               
                   
                 8.14 (s, 1H), 8.09 (s, 1H), 7.66 (t, J = 2.2 Hz, 1H), 7.50-7.44 (m, 3H), 7.41 (t, J = 9.0 Hz, 
               
               
                   
                 2H), 7.36 (d, J = 8.2 Hz, 2H), 7.23-7.19 (m, 3H), 7.16 (t, J = 8.9 Hz, 2H), 6.08 (d, J = 7.5 Hz, 
               
               
                   
                 1H), 5.11 (dd, J = 9.6, 4.6 Hz, 1H), 4.01 (dd, J = 13.5, 5.1 Hz, 1H), 3.84 (t, J = 12.1 Hz, 
               
               
                   
                 1H), 3.38 (s, 2H), 3.33-3.19 (m, 4H), 2.41-2.27 (m, 1H), 2.02-1.89 (m, 
               
               
                   
                 3H), 1.68 (s, 1H), 1.50 (s, 1H). 
               
               
                 832 
                 1H NMR (400 MHz, DMSO-d6) δ 8.68 (s, 1H), 7.95 (s, 1H), 7.74 (m, 1H), 7.66 (m, 
               
               
                   
                 1H), 7.52 (m, 4H), 7.39 (m, 2H), 7.14 (t, J = 8.0 Hz, 2H) 6.10 (s, 1H), 4.73 (m, 1H), 
               
               
                   
                 3.60 (m 2H), 3.18-3.04 (m, 4H), 2.32 (m, 2H), 2.14 (m, 2H), 1.20 (m, 3H). 
               
               
                 835 
                 1H NMR (400 MHz, DMSO-d6) δ 9.37 (s, 1H), 8.39 (s, 1H), 8.01 (s, 1H), 7.85 (m, 
               
               
                   
                 1H), 7.49-7.17 (m, 11 H), 7.17 (m, 4H), 6.03 (m, 1H), 5.07 (s, 2H), 4.69 (m, 1H), 
               
               
                   
                 4.07 (m 2H), 2.99 (m, 2H), 2.00 (m, 2H), 1.82 (m, 2H) 
               
               
                 838 
                 1H NMR (400 MHz, DMSO-d6) δ 9.39 (s, 1H), 9.02 (brs, 1H), 8.40 (s, 1H), 7.93 (m, 
               
               
                   
                 1H), 7.66 (m, 1H), 7.44 (m, 6H), 7.25-7.15 (m, 5H), 6.06 (m, 1H), 4.95 (m, 1H), 
               
               
                   
                 3.65 (m, 1H), 3.43 (m, 1H), 3.14 (m, 1H), 2.78 (m, 1H), 2.20 (m, 4H), 1.35 (s, 3H), 1.33 (s, 
               
               
                   
                 3H), 1.25 (t, J = 8 Hz, 3H). 
               
               
                 839 
                 1H NMR (400 MHz, DMSO-d6) δ 9.40 (s, 1H), 8.86 (m, 1H), 8.55 (m, 1H), 8.40 (s, 
               
               
                   
                 1H), 7.95 (s, 1H), 7.66 (m, 1H) 7.49-7.15 (m, 9H), 6.06 (m, 1H), 4.91 (m, 1H), 
               
               
                   
                 3.27 (m, 2H), 2.12 (m, 2H), 2.01 (m, 2H), 1.35 (s, 3H), 1.33 (s, 3H). 
               
               
                 840 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) δ 8.39 (d, J = 1.2 Hz, 1H), 7.94 (d, J = 7.2 Hz, 
               
               
                   
                 1H), 7.65 (d, J = 2.4 Hz, 1H), 7.50-7.37 (m, 4H), 7.23-7.12 (m, 4H), 6.04 (s, 
               
               
                   
                 1H), 4.64 (ddd, J = 11.8, 8.2, 3.8 Hz, 1H), 3.39-3.32 (m, 1H), 3.19-3.09 (m, 1H), 
               
               
                   
                 3.02 (td, J = 12.6, 3.7 Hz, 1H), 2.92 (dd, J = 12.9, 5.0 Hz, 1H), 2.44-2.35 (m, 1H), 
               
               
                   
                 2.05-1.94 (m, 1H), 0.76 (dd, J = 16.5, 11.0 Hz, 6H). 
               
               
                 843 
                 1H NMR (400 MHz, DMSO-d6) δ 9.45 (s, 1H), 8.41 (s, 1H), 8.01 (s, 1H), 7.66 (m, 
               
               
                   
                 1H), 7.44 (m, 5H), 7.25-7.15 (m, 3H), 6.05 (m, 1H), 4.69 (m, 1H), 3.91 (m, 2H), 
               
               
                   
                 3.43 (m, 2H), 1.94 (m, 4H). 
               
               
                 846 
                 1H NMR (400 MHz, DMSO-d6) δ 9.51 (s, 1H), 8.40 (s, 1H), 7.69 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.59 (d, J = 2.2 Hz, 1H), 7.48 (dd, J = 6.6, 2.6 Hz, 1H), 7.42 (ddd, J = 9.1, 7.4, 1.9 Hz, 
               
               
                   
                 3H), 7.26-7.22 (m, 1H), 7.20 (d, J = 2.4 Hz, 1H), 7.10 (t, J = 8.9 Hz, 2H), 6.14 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 5.91 (s, 1H), 3.76 (s, 3H). 
               
               
                 847 
                 1H NMR (400 MHz, DMSO-d6) δ 9.43 (s, 1H), 8.51 (s, 1H), 7.72 (d, J = 1.9 Hz, 1H), 
               
               
                   
                 7.65 (d, J = 2.3 Hz, 1H), 7.59 (d, J = 1.9 Hz, 1H), 7.49 (d, J = 7.2 Hz, 1H), 7.42 (dd, J = 8.7, 
               
               
                   
                 5.4 Hz, 2H), 7.39-7.35 (m, 2H), 7.30 (t, J = 8.8 Hz, 2H), 7.16 (ddd, J = 8.9, 4.1, 
               
               
                   
                 2.7 Hz, 1H), 7.07 (d, J = 2.4 Hz, 1H), 6.38 (d, J = 6.9 Hz, 1H), 3.67 (s, 3H). 
               
               
                 848 
                 1H NMR (400 MHz, DMSO-d6) δ 9.35 (s, 1H), 8.38 (s, 1H), 8.00 (s, 1H), 7.66 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.47-7.40 (m, 3H), 7.39-7.27 (m, 10H), 7.25-7.16 (m, 4H), 6.02 (d, J = 8.4 Hz, 
               
               
                   
                 1H), 5.14-5.04 (m, 3H), 4.68 (ddt, J = 11.4, 7.9, 4.1 Hz, 1H), 4.48 (td, J = 6.5, 
               
               
                   
                 4.5 Hz, 1H), 4.32 (t, J = 5.2 Hz, 1H), 4.08 (s, 1H), 4.04 (d, J = 4.1 Hz, 2H), 
               
               
                   
                 3.35 (td, J = 6.5, 5.2 Hz, 1H), 2.00 (d, J = 12.1 Hz, 2H), 1.83 (ddt, J = 12.2, 7.4, 3.7 Hz, 
               
               
                   
                 2H), 1.59 (ddd, J = 8.2, 6.3, 2.0 Hz, 1H), 1.46 (ddd, J = 13.3, 7.7, 6.3 Hz, 1H), 
               
               
                   
                 1.35 (ddt, J = 12.9, 8.7, 6.4 Hz, 1H). 
               
               
                 849 
                 1H NMR (400 MHz, DMSO-d6) δ 9.39 (s, 1H), 9.33 (s, 1H), 8.40 (s, 1H), 7.99 (s, 
               
               
                   
                 1H), 7.66 (d, J = 2.3 Hz, 1H), 7.51-7.44 (m, 4H), 7.41 (t, J = 9.0 Hz, 1H), 7.36 (s, 
               
               
                   
                 1H), 7.21 (qd, J = 4.5, 2.7 Hz, 3H), 7.18-7.11 (m, 2H), 6.06 (d, J = 7.3 Hz, 1H), 
               
               
                   
                 4.72 (tt, J = 11.9, 4.2 Hz, 1H), 3.60 (d, J = 12.3 Hz, 2H), 3.30-2.97 (m, 5H), 
               
               
                   
                 2.39-2.28 (m, 3H), 2.16 (ddd, J = 14.8, 8.6, 3.6 Hz, 2H), 1.22 (t, J = 7.3 Hz, 4H). 
               
               
                 850 
                 1H NMR (400 MHz, DMSO-d6) δ 9.37 (s, 1H), 8.62 (s, 1H), 8.40 (s, 1H), 7.97 (s, 
               
               
                   
                 1H), 7.65 (d, J = 2.2 Hz, 1H), 7.49-7.43 (m, 3H), 7.41 (t, J = 9.0 Hz, 1H), 7.36 (d, J = 8.6 Hz, 
               
               
                   
                 1H), 7.20 (dq, J = 6.7, 2.6 Hz, 2H), 7.14 (t, J = 8.9 Hz, 2H), 6.06 (d, J = 8.2 Hz, 
               
               
                   
                 1H), 4.74 (ddt, J = 10.9, 7.9, 4.1 Hz, 1H), 3.38 (d, J = 13.2 Hz, 3H), 3.06 (dd, J = 13.3, 
               
               
                   
                 10.3 Hz, 2H), 2.29-2.17 (m, 2H), 2.16-2.00 (m, 2H). 
               
               
                 851 
                 1H NMR (400 MHz, DMSO-d6) δ 9.38 (s, 1H), 8.64 (s, 1H), 8.40 (s, 1H), 7.97 (s, 
               
               
                   
                 1H), 7.65 (d, J = 2.2 Hz, 1H), 7.50-7.43 (m, 3H), 7.41 (t, J = 9.0 Hz, 1H), 
               
               
                   
                 7.38-7.34 (m, 1H), 7.25-7.18 (m, 2H), 7.14 (t, J = 8.8 Hz, 2H), 6.06 (d, J = 7.9 Hz, 1H), 4.75 (tt, 
               
               
                   
                 J = 11.0, 4.1 Hz, 1H), 3.38 (d, J = 12.8 Hz, 2H), 3.05 (q, J = 11.9 Hz, 2H), 
               
               
                   
                 2.30-2.18 (m, 2H), 2.16-1.98 (m, 2H). 
               
               
                 852 
                 1H NMR (400 MHz, DMSO-d6) δ 9.80 (s, 1H), 9.43 (s, 1H), 8.39 (s, 1H), 7.89 (s, 
               
               
                   
                 1H), 7.68 (d, J = 2.2 Hz, 1H), 7.55 (t, J = 1.7 Hz, 1H), 7.41 (ddt, J = 14.4, 11.9, 5.1 Hz, 
               
               
                   
                 6H), 7.24-7.19 (m, 2H), 6.09 (d, J = 5.2 Hz, 1H), 4.29 (d, J = 5.7 Hz, 2H), 3.99 (s, 
               
               
                   
                 3H), 3.35-3.19 (m, 2H), 3.12-2.92 (m, 2H), 1.91 (dt, J = 6.9, 3.8 Hz, 2H), 1.73 (p, J = 7.6, 
               
               
                   
                 7.1 Hz, 2H). 
               
               
                 853 
                 1H NMR (400 MHz, DMSO-d6) δ 9.32 (s, 1H), 8.38 (s, 1H), 7.60 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.45-7.36 (m, 7H), 7.27 (d, J = 0.8 Hz, 1H), 7.24-7.15 (m, 3H), 7.12 (t, J = 8.9 Hz, 
               
               
                   
                 2H), 7.08 (d, J = 2.4 Hz, 2H), 5.81-5.74 (m, 1H), 3.75 (s, 3H). 
               
               
                 854 
                 1H NMR (400 MHz, DMSO-d6) δ 9.43 (s, 1H), 8.45 (s, 1H), 7.87 (s, 1H), 7.73 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.50-7.43 (m, 4H), 7.40 (t, J = 9.0 Hz, 1H), 7.24 (d, J = 2.6 Hz, 2H), 
               
               
                   
                 7.23-7.20 (m, 1H), 7.17 (t, J = 8.9 Hz, 2H), 6.24-6.18 (m, 1H), 3.81 (s, 3H). 
               
               
                 856 
                 1H NMR (400 MHz, DMSO-d6) δ 9.36 (s, 1H), 9.21 (s, 1H), 8.40 (s, 1H), 8.00 (s, 
               
               
                   
                 1H), 7.66 (d, J = 2.2 Hz, 1H), 7.48-7.43 (m, 4H), 7.39 (td, J = 6.6, 3.1 Hz, 5H), 
               
               
                   
                 7.24-7.21 (m, 1H), 7.20 (d, J = 2.6 Hz, 2H), 6.06 (d, J = 8.2 Hz, 1H), 4.72 (ddt, J = 11.9, 
               
               
                   
                 7.9, 4.2 Hz, 1H), 3.60 (d, J = 12.6 Hz, 3H), 3.25-2.92 (m, 5H), 2.39-2.27 (m, 3H), 
               
               
                   
                 2.25-2.07 (m, 3H), 1.22 (t, J = 7.3 Hz, 3H). 
               
               
                 857 
                 1H NMR (400 MHz, DMSO-d6) δ 9.39 (s, 1H), 8.65 (s, 1H), 8.40 (s, 1H), 7.99 (s, 
               
               
                   
                 1H), 7.65 (d, J = 2.2 Hz, 1H), 7.48-7.42 (m, 3H), 7.42-7.35 (m, 4H), 7.24-7.21 (m, 
               
               
                   
                 1H), 6.07 (d, J = 7.8 Hz, 1H), 4.75 (tt, J = 11.0, 4.1 Hz, 1H), 3.45-3.33 (m, 2H), 
               
               
                   
                 3.05 (q, J = 11.7 Hz, 2H), 2.30-2.17 (m, 2H), 2.15-2.01 (m, 2H). 
               
               
                 858 
                 1H NMR (400 MHz, DMSO-d6) δ 9.37 (s, 1H), 9.25 (d, J = 9.6 Hz, 1H), 8.40 (s, 1H), 
               
               
                   
                 8.00 (s, 1H), 7.66 (d, J = 2.2 Hz, 1H), 7.49-7.42 (m, 5H), 7.42-7.36 (m, 5H), 
               
               
                   
                 7.26-7.21 (m, 1H), 6.07 (d, J = 8.1 Hz, 2H), 4.72 (tt, J = 12.0, 4.1 Hz, 1H), 3.27-2.97 (m, 
               
               
                   
                 6H), 2.39-2.28 (m, 3H), 2.14 (q, J = 12.7 Hz, 2H), 1.22 (t, J = 7.3 Hz, 3H). 
               
               
                 859 
                 1H NMR (400 MHz, DMSO-d6) δ 9.38 (s, 1H), 8.65 (s, 1H), 8.40 (s, 1H), 7.99 (s, 
               
               
                   
                 1H), 7.65 (d, J = 2.2 Hz, 1H), 7.49-7.42 (m, 3H), 7.42-7.35 (m, 4H), 7.24-7.21 (m, 
               
               
                   
                 1H), 7.20 (d, J = 2.6 Hz, 1H), 6.07 (d, J = 8.0 Hz, 1H), 4.75 (tt, J = 11.1, 4.1 Hz, 1H), 
               
               
                   
                 3.38 (d, J = 13.4 Hz, 3H), 3.05 (q, J = 11.7 Hz, 2H), 2.28-2.18 (m, 2H), 
               
               
                   
                 2.15-2.00 (m, 2H). 
               
               
                 862 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) δ 8.67 (d, J = 7.1 Hz, 2H), 8.20 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 8.16-8.09 (m, 2H), 7.55 (dd, J = 6.6, 2.6 Hz, 1H), 7.45 (t, J = 9.0 Hz, 
               
               
                   
                 1H), 7.42-7.36 (m, 2H), 7.31 (ddd, J = 8.8, 4.2, 2.6 Hz, 1H), 7.21-7.13 (m, 2H), 
               
               
                   
                 6.44 (d, J = 7.7 Hz, 1H), 5.67 (dd, J = 7.7, 5.5 Hz, 1H), 4.96 (d, J = 5.5 Hz, 1H). 
               
               
                 864 
                 1H NMR (400 MHz, DMSO-d6) δ 9.40 (s, 1H), 9.11 (brs, 1H), 8.40 (s, 1H), 8.09 (d, J = 8 Hz, 
               
               
                   
                 1H), 7.66 (m, 1H), 7.43 (m, 5H), 7.19 (m, 4H), 6.09 (m, 1H), 5.38 (m, 1H), 
               
               
                   
                 3.67 (m, 2H), 3.36 (m, 2H), 2.48 (m, 1H), 2.27 (m, 1H). 
               
               
                 865 
                 1H NMR (400 MHz, DMSO-d6) δ 10.1 (m, 1H), 9.41 (s, 1H), 8.40 (s, 1H), 8.10 (d, J = 8 Hz, 
               
               
                   
                 1H), 7.66 (m, 1H), 7.45 (m, 5H), 7.19 (m, 4H), 6.11 (m, 1H), 5.43 (m, 1H), 
               
               
                   
                 4.01 (m, 1H), 3.63 (m, 2H), 3.23 (m, 3H), 2.68 (m, 1H), 2.33 (m, 1H), 121 (t, J = 8 Hz, 3H). 
               
               
                 870 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) δ 8.39 (s, 1H), 8.08 (d, J = 8.9 Hz, 
               
               
                   
                 1H), 7.65 (d, J = 2.3 Hz, 1H), 7.51-7.43 (m, 3H), 7.41 (t, J = 9.1 Hz, 1H), 
               
               
                   
                 7.25-7.18 (m, 2H), 7.15 (t, J = 8.8 Hz, 2H), 6.10 (d, J = 4.9 Hz, 2H), 5.53 (t, J = 9.2 Hz, 1H), 
               
               
                   
                 4.64 (d, J = 11.5 Hz, 1H), 4.50 (d, J = 6.6 Hz, 2H), 4.43 (d, J = 10.5 Hz, 2H), 3.30 (dt, 
               
               
                   
                 J = 20.9, 7.3 Hz, 2H), 1.09 (q, J = 6.9 Hz, 3H). 
               
               
                 871 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) δ 8.39 (d, J = 0.8 Hz, 1H), 8.10 (d, J = 1.3 Hz, 
               
               
                   
                 1H), 8.09-8.05 (m, 1H), 7.65 (d, J = 2.3 Hz, 1H), 7.44 (dt, J = 7.3, 2.5 Hz, 
               
               
                   
                 4H), 7.39 (dd, J = 8.7, 6.7 Hz, 4H), 7.25-7.19 (m, 3H), 6.17-6.06 (m, 1H), 
               
               
                   
                 5.62-5.47 (m, 1H), 4.63 (s, 2H), 4.50 (d, J = 6.6 Hz, 2H), 4.42 (s, 2H), 3.37-3.19 (m, 2H), 
               
               
                   
                 1.09 (q, J = 6.8 Hz, 3H). 
               
               
                 872 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) δ 8.40 (d, J = 0.7 Hz, 1H), 8.07 (s, 
               
               
                   
                 1H), 7.65 (d, J = 2.3 Hz, 1H), 7.49-7.42 (m, 3H), 7.39 (t, J = 8.5 Hz, 3H), 7.22 (qd, J = 4.2, 
               
               
                   
                 2.7 Hz, 2H), 6.11 (s, 1H), 5.64-5.47 (m, 1H), 4.43 (dd, J = 11.5, 8.7 Hz, 2H), 
               
               
                   
                 4.35 (ddd, J = 11.5, 6.7, 3.4 Hz, 2H). 
               
               
                 873 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) δ 8.37 (s, 1H), 8.01 (d, J = 2.8 Hz, 
               
               
                   
                 1H), 7.63 (d, J = 2.3 Hz, 1H), 7.50-7.30 (m, 6H), 7.18 (dq, J = 5.4, 3.0, 2.5 Hz, 2H), 
               
               
                   
                 7.12 (t, J = 8.8 Hz, 2H), 7.08-7.00 (m, 1H), 6.04 (d, J = 4.7 Hz, 1H), 6.02-5.95 (m, 
               
               
                   
                 1H), 5.20 (tt, J = 7.7, 4.1 Hz, 1H), 3.42 (ddd, J = 12.4, 7.1, 3.4 Hz, 1H), 3.28-3.20 (m, 
               
               
                   
                 1H), 3.20-3.05 (m, 2H), 2.76 (dd, J = 13.9, 8.7 Hz, 1H), 2.34 (dq, J = 13.5, 7.9 Hz, 
               
               
                   
                 2H), 2.15-2.03 (m, 1H). 
               
               
                 874 
                 1H NMR (400 MHz, DMSO-d6) δ 9.34 (s, 1H), 8.42 (s, 1H), 8.23 (s, 1H), 8.18 (s, 
               
               
                   
                 1H), 8.02 (s, 1H), 7.64 (m, 2H), 7.42 (m, 3H), 7.21 (m, 2H), 6.29 (m, 1H), 4.77 (m, 
               
               
                   
                 1H), 3.39 (m, 2H), 3.07 (m, 2H), 2.27 (m, 2H), 2.09 (m, 2H). 
               
               
                 875 
                 1H NMR (400 MHz, DMSO-d6) δ 9.39 (s, 1H), 8.75 (brs, 1H), 8.45 (s, 1H), 8.07 (s, 
               
               
                   
                 1H), 7.66 (m, 1H), 7.37 (m, 5H), 7.16 (m, 2H), 6.06 (m, 1H), 4.75 (m, 1H), 3.39 (m, 
               
               
                   
                 2H), 3.06 (m, 2H), 2.24 (m, 2H), 2.10 (m, 2H). 
               
               
                 876 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) δ 8.40 (s, 1H), 8.00 (s, 1H), 7.64 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.45 (dd, J = 8.5, 5.7 Hz, 4H), 7.40 (t, J = 9.0 Hz, 2H), 7.30 (dd, J = 11.1, 
               
               
                   
                 5.9 Hz, 6H), 7.25-7.22 (m, 1H), 7.20 (t, J = 2.4 Hz, 2H), 7.12 (t, J = 8.8 Hz, 
               
               
                   
                 3H), 6.04 (d, J = 1.6 Hz, 1H), 5.20 (s, 1H), 5.12-4.94 (m, 3H), 3.83 (dt, J = 12.3, 6.1 Hz, 
               
               
                   
                 1H), 3.80-3.72 (m, 1H), 3.64 (d, J = 11.9 Hz, 1H), 2.40 (s, 2H), 2.29 (d, J = 14.8 Hz, 
               
               
                   
                 2H). 
               
               
                 878 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) δ 8.39 (s, 1H), 8.00 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.63 (d, J = 2.3 Hz, 1H), 7.49-7.25 (m, 12H), 7.25-7.20 (m, 1H), 7.19 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 6.04 (s, 1H), 5.20 (s, 1H), 5.13-4.94 (m, 2H), 3.84 (dd, J = 11.6, 6.5 Hz, 
               
               
                   
                 1H), 3.79-3.73 (m, 1H), 3.66 (s, 1H), 3.46 (d, J = 9.5 Hz, 1H), 2.40 (s, 2H), 2.31 (s, 
               
               
                   
                 2H). 
               
               
                 880 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) δ 8.40 (s, 1H), 8.07 (d, J = 8.0 Hz, 
               
               
                   
                 1H), 7.65 (dd, J = 2.4, 1.5 Hz, 1H), 7.45 (dt, J = 8.5, 3.0 Hz, 4H), 7.38 (t, J = 8.7 Hz, 
               
               
                   
                 4H), 7.21 (dq, J = 8.4, 2.9 Hz, 3H), 6.08 (s, 1H), 5.37 (qt, J = 6.5, 2.7 Hz, 2H), 
               
               
                   
                 3.74-3.64 (m, 1H), 3.59 (dd, J = 12.8, 3.8 Hz, 1H), 3.36 (ddd, J = 8.2, 6.4, 1.7 Hz, 3H), 
               
               
                   
                 2.47-2.38 (m, 1H), 2.26 (tdd, J = 10.0, 7.9, 5.2 Hz, 2H). 
               
               
                 881 
                 1H NMR (400 MHz, DMSO-d6) δ 9.36 (s, 1H), 8.38 (s, 1H), 7.87 (s, 1H), 7.65 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.47 (dd, J = 6.7, 2.6 Hz, 1H), 7.43 (d, J = 8.6 Hz, 2H), 7.41-7.35 (m, 
               
               
                   
                 4H), 7.22 (dd, J = 7.3, 2.1 Hz, 2H), 6.07 (d, J = 8.7 Hz, 1H), 3.98 (s, 3H). 
               
               
                 882 
                 1H NMR (400 MHz, DMSO-d6) δ 9.51 (s, 1H), 8.41 (s, 1H), 7.86 (s, 1H), 7.66 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.49 (dd, J = 6.6, 2.6 Hz, 1H), 7.48-7.39 (m, 4H), 7.29-7.20 (m, 3H), 
               
               
                   
                 7.19-7.10 (m, 3H), 6.07 (s, 1H), 3.98 (s, 3H). 
               
               
                 883 
                 1H NMR (400 MHz, DMSO-d6) δ 9.40 (s, 1H), 8.44 (s, 1H), 7.94 (s, 1H) 7.65 (m, 
               
               
                   
                 1H), 7.44-7.21 (m, 8H), 7.10 (m, 1H), 6.98 (m, 3H), 6.00 (m, 1H), 5.06 (s, 2H), 
               
               
                   
                 4.67 (m, 1H), 4.06 (m 2H), 2.98 (m, 2H), 2.25 (s, 3H), 1.98 (m, 2H), 1.82 (m, 2H). 
               
               
                 885 
                 1H NMR (400 MHz, DMSO-d6) δ 9.38 (m, 2H), 9.26 (brs, 1H), 8.45 (s, 1H), 7.97 (s, 
               
               
                   
                 1H) 7.65 (m, 1H), 7.34 (m, 2H), 7.24 (m, 2H), 7.09 (m, 1H), 6.99 (m, 3H), 6.03 (m, 
               
               
                   
                 1H), 4.70 (m, 1H), 3.59 (m 2H), 3.24-3.04 (m, 4H), 2.27 (m, 5H), 2.15 (m, 2H), 
               
               
                   
                 1.20 (m, 3H). 
               
               
                 886 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) 7.50-7.43 (m, 3H), 7.40 (t, J = 9.0 Hz, 
               
               
                   
                 1H), 7.23-7.20 (m, 1H), 7.19 (d, J = 2.5 Hz, 2H), 7.13 (t, J = 8.8 Hz, 2H), 6.05 (s, 
               
               
                   
                 1H), 4.74 (tt, J = 11.1, 4.1 Hz, 1H), 3.37 (dt, J = 13.1, 3.6 Hz, 2H), 3.04 (td, J = 12.9, 
               
               
                   
                 3.1 Hz, 2H), 2.29-2.15 (m, 2H), 2.08 (qd, J = 12.9, 12.5, 4.0 Hz, 2H). 
               
               
                 887 
                 1H NMR (400 MHz, DMSO-d6) δ 9.42 (s, 1H), 9.00 (s, 1H), 8.44 (s, 1H), 7.62 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.51-7.37 (m, 6H), 7.31-7.28 (m, 1H), 7.26-7.18 (m, 5H), 6.02 (d, J = 7.8 Hz, 
               
               
                   
                 1H), 3.76 (s, 3H). 
               
               
                 888 
                 1H NMR (400 MHz, DMSO-d6) δ 9.44 (s, 1H), 8.39 (s, 1H), 7.71 (s, 1H), 7.68 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.48 (dd, J = 6.6, 2.6 Hz, 1H), 7.45-7.37 (m, 4H), 7.34-7.28 (m, 3H), 
               
               
                   
                 7.28-7.20 (m, 4H), 6.10 (s, 1H). 
               
               
                 889 
                 1H NMR (400 MHz, DMSO-d6) δ 9.28 (m, 2H), 8.46 (s, 1H), 8.12 (s, 1H), 7.66 (m, 
               
               
                   
                 1H), 7.37 (m, 5H), 7.16 (m, 2H), 6.04 (m, 1H), 4.71 (m, 1H), 3.61 (m 2H), 
               
               
                   
                 3.21-3.05 (m, 4H), 2.33 (m, 2H), 2.14 (m, 2H), 1.20 (m, 3H). 
               
               
                 890 
                 1H NMR (400 MHz, DMSO-d6) δ 9.36 (s, 1H), 8.45 (s, 1H), 8.07 (s, 1H) 7.65 (m, 
               
               
                   
                 1H), 7.44-7.21 (m, 8H), 7.18 (m, 1H), 7.11 (m, 1H), 6.98 (m, 3H), 6.01 (m, 1H), 
               
               
                   
                 5.06 (s, 2H), 4.69 (m, 1H), 4.08 (m 2H), 3.00 (m, 2H), 2.02 (m, 2H), 1.83 (m, 2H). 
               
               
                 893 
                 1H NMR (400 MHz, DMSO-d6) δ 9.46 (s, 1H), 8.40 (s, 1H), 7.73 (s, 1H), 7.66 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.49 (dd, J = 6.6, 2.7 Hz, 1H), 7.47-7.38 (m, 4H), 7.28-7.19 (m, 3H), 
               
               
                   
                 7.19-7.09 (m, 3H), 6.11 (d, J = 4.8 Hz, 1H). 
               
               
                 894 
                 1H NMR D2O exchange (400 MHz, DMSO-d6) δ 9.00 (d, J = 2.1 Hz, 1H), 8.44 (s, 
               
               
                   
                 1H), 7.60 (d, J = 2.3 Hz, 1H), 7.45 (s, 5H), 7.44 (d, J = 2.8 Hz, 1H), 7.40 (t, J = 9.0 Hz, 
               
               
                   
                 1H), 7.29-7.27 (m, 1H), 7.23-7.18 (m, 2H), 6.01 (s, 1H), 3.76 (s, 3H). 
               
               
                 896 
                 1H NMR (400 MHz, DMSO-d6) δ 9.45 (s, 1H), 8.41 (s, 1H), 8.07 (s, 1H), 7.66 (m, 
               
               
                   
                 1H), 7.55 (m, 2H), 7.44-7.17 (m, 10 H), 6.10 (m, 1H), 5.07 (s, 2H), 4.70 (m, 1H), 
               
               
                   
                 4.07 (m 2H), 3.00 (m, 2H), 2.01 (m, 2H), 1.84 (m, 2H). 
               
               
                 897 
                 1H NMR (400 MHz, DMSO-d6) δ 9.38 (s, 1H), 8.40 (s, 1H), 8.03 (s, 1H), 7.66 (m, 
               
               
                   
                 1H), 7.56 (m, 2H), 7.43 (m, 3H), 7.32 (m, 2H), 7.21 (m, 2H), 6.11 (m, 1H), 4.75 (m, 
               
               
                   
                 1H), 3.38 (m, 2H), 3.05 (m, 2H), 2.23 (m, 2H), 2.10 (m, 2H). 
               
               
                 899 
                 1H NMR (400 MHz, DMSO-d6) δ 9.38 (s, 1H), 8.41 (s, 1H), 8.05 (s, 1H) 7.65 (m, 
               
               
                   
                 1H), 7.44-7.21 (m, 13H), 7.20 (m, 3H), 6.03 (m, 1H), 5.07 (s, 2H), 4.70 (m, 1H), 
               
               
                   
                 4.07 (m 2H), 3.00 (m, 2H), 2.01 (m, 2H), 1.82 (m, 2H). 
               
               
                 901 
                 1H NMR (400 MHz, DMSO-d6) δ 9.33 (m, 1H), 9.25 (brs, 1H), 8.42 (s, 1H), 8.03 (s, 
               
               
                   
                 1H) 7.66 (m, 1H), 7.44-7.14 (m, 6H), 7.20 (m, 2H) 6.06 (m, 1H), 4.71 (m, 1H), 
               
               
                   
                 3.61 (m 2H), 3.22-3.05 (m, 4H), 2.33 (m, 2H), 2.15 (m, 2H), 1.20 (m, 3H). 
               
               
                 902 
                 1H NMR (400 MHz, DMSO-d6) δ 9.46 (s, 1H), 8.40 (s, 1H), 8.01 (s, 1H) 7.66 (m, 
               
               
                   
                 1H), 7.44-7.21 (m, 11H), 7.04 (m, 2H), 6.78 (m, 1H) 5.99 (m, 1H), 4.69 (m, 1H), 
               
               
                   
                 4.07 (m 2H), 3.66 (s, 3H), 2.99 (m, 2H), 2.01 (m, 2H), 1.84 (m, 2H). 
               
               
                 903 
                 1H NMR (400 MHz, DMSO-d6) δ 9.43 (s, 1H), 8.69 (brs, 1H), 8.40 (s, 1H), 7.98 (s, 
               
               
                   
                 1H) 7.66 (m, 1H), 7.44 (m, 3H), 7.23 (m, 3H), 7.04 (m, 2H), 6.79 (m, 1H) 6.01 (m, 
               
               
                   
                 1H), 4.75 (m, 1H), 3.66 (s, 3H), 3.38 (m 2H), 3.05 (m, 2H), 2.23 (m, 2H), 2.10 (m, 
               
               
                   
                 2H). 
               
               
                 904 
                 1H NMR (400 MHz, DMSO-d6) δ 9.38 (s, 1H), 9.30 (brs, 1H), 8.40 (s, 1H), 8.12 (s, 
               
               
                   
                 1H), 7.98 (s, 1H) 7.66 (m, 1H), 7.44 (m, 2H), 7.23 (m, 3H), 7.04 (m, 2H), 6.80 (m, 1H) 
               
               
                   
                 6.01 (m, 1H), 4.73 (m, 1H), 3.67 (s, 3H), 3.60 (m 2H), 3.24-3.04 (m, 4H), 2.33 (m, 
               
               
                   
                 2H), 2.15 (m, 2H), 1.21 (m, 3H). 
               
               
                 906 
                 1H NMR (400 MHz, DMSO-d6) δ 9.41 (m, 2H), 8.69 (brs, 1H), 8.41 (s, 1H), 8.02 (s, 
               
               
                   
                 1H) 7.67 (m, 1H), 7.44-7.04 (m, 9H), 7.07 (m, 1H), 6.09 (m, 1H), 4.76 (m, 1H), 
               
               
                   
                 3.38 (m, 2H), 3.04 (m, 2H), 2.18 (m, 2H), 2.05 (m, 2H). 
               
               
                 907 
                 1H NMR (400 MHz, DMSO-d6) δ 9.40 (m, 2H), 8.41 (s, 1H), 8.16 (s, 1H), 8.03 (s, 
               
               
                   
                 1H) 7.67 (m, 1H), 7.44-7.04 (m, 9H), 7.07 (m, 1H) 6.09 (m, 1H), 4.73 (m, 1H), 
               
               
                   
                 3.61 (m 2H), 3.24-3.04 (m, 4H), 2.33 (m, 2H), 2.17 (m, 2H), 1.20 (m, 3H). 
               
               
                 908 
                 1H NMR (400 MHz, DMSO-d6) δ 9.36 (s, 1H), 9.14 (s, 1H), 8.40 (s, 1H), 7.98 (s, 
               
               
                   
                 1H), 7.66 (s, 1H), 7.49-7.34 (m, 7H), 6.05 (d, J = 8.3 Hz, 1H), 4.72 (s, 1H), 3.60 (d, J = 12.3 Hz, 
               
               
                   
                 2H), 3.26-2.99 (m, 3H), 2.34-2.26 (m, 2H), 2.23-2.06 (m, 1H), 1.22 (t, J = 7.4 Hz, 
               
               
                   
                 3H). 
               
               
                 909 
                 1H NMR (400 MHz, DMSO-d6) δ 9.42 (s, 1H), 8.42 (s, 1H), 8.09 (s, 1H) 7.67 (m, 
               
               
                   
                 2H), 7.58 (m, 1H), 7.44-7.21 (m, 11H), 7.20 (m, 3H), 6.05 (m, 1H), 5.07 (s, 2H), 
               
               
                   
                 4.70 (m, 1H), 4.08 (m 2H), 3.00 (m, 2H), 2.02 (m, 2H), 1.85 (m, 2H). 
               
               
                 912 
                 1H NMR (400 MHz, DMSO-d6) δ 9.44 (s, 1H), 8.38 (s, 1H), 7.89 (s, 1H), 7.69 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.49 (dd, J = 6.6, 2.6 Hz, 1H), 7.46-7.38 (m, 4H), 7.35-7.27 (m, 3H), 
               
               
                   
                 7.26-7.21 (m, 2H), 6.11 (d, J = 6.3 Hz, 1H), 5.22 (s, 2H). 
               
               
                 913 
                 1H NMR (400 MHz, DMSO-d6) δ 9.43 (s, 1H), 8.40 (s, 1H), 8.02 (s, 1H) 7.65 (m, 
               
               
                   
                 1H), 7.44-7.21 (m, 16H), 6.04 (m, 1H), 5.07 (s, 2H), 4.69 (m, 1H), 4.06 (m 2H), 
               
               
                   
                 3.00 (m, 2H), 2.01 (m, 2H), 1.84 (m, 2H). 
               
               
                 914 
                 1H NMR (400 MHz, DMSO-d6) δ 9.42 (s, 1H), 8.72 (brs, 1H), 8.40 (m, 2H), 8.00 (s, 
               
               
                   
                 1H), 7.66 (m, 1H), 7.43 (m, 7H), 7.22 (m, 2H), 6.07 (m, 1H), 4.76 (m, 1H), 3.38 (m, 
               
               
                   
                 2H), 3.07 (m, 2H), 2.24 (m, 2H), 2.10 (m, 2H). 
               
               
                 915 
                 1H NMR (400 MHz, DMSO-d6) δ 9.44 (s, 1H), 8.40 (s, 1H), 7.96 (s, 1H) 7.66 (m, 
               
               
                   
                 1H), 7.44-7.21 (m, 9H), 7.20 (m, 2H), 7.10 (m, 2H), 5.97 (m, 1H), 5.07 (s, 2H), 
               
               
                   
                 4.68 (m, 1H), 4.06 (m 2H), 2.97 (m, 2H), 2.22 (s, 3H), 1.99 (m, 2H), 1.83 (m, 2H). 
               
               
                 917 
                 1H NMR (400 MHz, DMSO-d6) δ 9.39 (m, 1H), 9.27 (brs, 1H), 8.39 (s, 1H), 8.00 (s, 
               
               
                   
                 1H), 7.66 (m, 1H), 7.42 (m, 2H) 7.31 (m, 3H), 7.17 (m, 4H), 5.99 (m, 1H), 4.71 (m, 
               
               
                   
                 1H), 3.60 (m 2H), 3.21-3.05 (m, 4H), 2.31 (m, 2H), 2.23 (s, 3H), 2.14 (m, 2H), 
               
               
                   
                 1.21 (m, 3H). 
               
               
                 920 
                 1H NMR (400 MHz, DMSO-d6) δ 9.49 (s, 1H), 8.39 (s, 1H), 7.85 (s, 1H), 7.67 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.49 (dd, J = 6.6, 2.6 Hz, 1H), 7.45-7.39 (m, 4H), 7.34-7.28 (m, 2H), 
               
               
                   
                 7.27-7.20 (m, 4H), 6.06 (s, 1H), 3.98 (s, 3H). 
               
               
                 925 
                 1H NMR (400 MHz, Methanol-d4) δ 8.43 (s, 1H), 7.84 (m, 2H), 7.66 (m, 1H), 
               
               
                   
                 7.50 (m, 2H), 7.45-7.02 (m, 7H), 6.11 (m, 1H), 3.87 (m, 2H), 3.48 (m, 2H), 
               
               
                   
                 3.36-3.27 (m, 3H), 2.39-2.25 (m, 1H), 1.24-1.08 (m, 4H). 
               
               
                 926 
                 1H NMR (400 MHz, Methanol-d4) δ 8.48 (s, 1H), 7.88 (s, 1H), 7.83 (s, 1H), 7.78 (m, 
               
               
                   
                 1H), 7.69 (m, 1H), 7.65 (m, 1H), 7.56 (t, J = 7.8 Hz, 1H), 7.13 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 4.22 (d, J = 15.0 Hz, 1H), 4.06 (d, J = 15.0 Hz, 1H), 3.89 (m, 1H), 2.52 (s, 1H), 1.82 (s, 
               
               
                   
                 6H), 1.26-1.18 (m, 2H), 1.18-1.10 (m, 2H).0 
               
               
                 927 
                 1H NMR (400 MHz, Methanol-d4) δ 8.46 (s, 1H), 7.80 (s, 1H), 7.62 (m, 1H), 
               
               
                   
                 7.52-7.42 (m, 2H), 7.16-7.04 (m, 3H), 6.06 (s, 1H), 4.19 (d, J = 15.1 Hz, 1H), 4.08 (d, J = 15.0 Hz, 
               
               
                   
                 1H), 3.87 (m, 1H), 2.52 (s, 1H), 1.82 (s, 6H), 1.18 (m, 2H), 1.17-1.11 (m, 
               
               
                   
                 2H). 
               
               
                 928 
                 1H NMR (400 MHz, Methanol-d4) δ 8.46 (s, 1H), 7.85 (s, 1H), 7.57 (m, 1H), 7.48 (m, 
               
               
                   
                 1H), 7.42 (m, 1H), 7.37-7.28 (m, 2H), 7.09 (d, J = 2.3 Hz, 1H), 6.40 (s, 1H), 
               
               
                   
                 4.19-4.04 (m, 2H), 3.89 (m, 1H), 2.52 (s, 1H), 1.82 (s, 6H), 1.20 (m, 2H), 1.16-1.14 (m, 
               
               
                   
                 2H). 
               
               
                 929 
                 1H NMR (400 MHz, Methanol-d4) δ 8.48 (s, 1H), 7.84 (s, 1H), 7.65 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.50-7.44 (m, 2H), 7.39-7.33 (m, 2H), 7.04 (d, J = 2.3 Hz, 1H), 4.83-4.75 (m, 
               
               
                   
                 1H), 4.21 (d, J = 13.9 Hz, 1H), 3.80 (d, J = 12.5 Hz, 2H), 3.69 (d, J = 14.0 Hz, 1H), 
               
               
                   
                 3.27-3.16 (m, 2H), 2.56-2.34 (m, 4H), 1.46 (s, 9H), 0.96 (s, 9H). 
               
               
                 930 
                 1H NMR (400 MHz, DMSO-d6) δ 8.23 (d, J = 6.8 Hz, 1H), 8.03 (d, J = 1.1 Hz, 1H), 
               
               
                   
                 7.79 (d, J = 2.2 Hz, 1H), 7.61-7.45 (m, 3H), 7.39-7.19 (m, 9H), 5.65 (td, J = 8.4, 5.1 Hz, 
               
               
                   
                 1H), 3.98 (dd, J = 7.5, 4.1 Hz, 1H), 2.71-2.53 (m, 2H), 2.42-2.12 (m, 2H), 
               
               
                   
                 1.23-1.07 (m, 4H). 
               
               
                 931 
                 1H NMR (400 MHz, DMSO-d6) δ 8.33 (s, 1H), 8.11 (d, J = 2.4 Hz, 1H), 8.04 (s, 1H), 
               
               
                   
                 7.65 (s, 1H), 7.58-7.50 (m, 3H), 7.35 (d, J = 2.6 Hz, 1H), 7.17-7.09 (m, 2H), 
               
               
                   
                 4.04-3.92 (m, 2H), 3.49 (s, 3H), 3.42 (dd, J = 13.9, 5.4 Hz, 1H), 1.19-1.04 (m, 4H), 
               
               
                   
                 0.88 (s, 9H). 
               
               
                 932 
                 1H NMR (400 MHz, Chloroform-d) δ 8.28 (s, 1H), 7.55 (m, 2H), 7.49-7.37 (m, 2H), 
               
               
                   
                 7.41-7.30 (m, 2H), 7.34-7.25 (m, 4H), 7.18 (m, 1H), 7.04 m, 3H), 5.93 (m, 1H), 
               
               
                   
                 3.73 (m, 2H), 3.01 (s, 3H), 1.68-1.57 (m, 1H), 1.28-1.19 (m, 4H), 1.23-1.10 (m, 
               
               
                   
                 2H). 
               
               
                 933 
                 1H NMR (400 MHz, Methanol-d4) δ 8.36 (s, 1H), 8.10-8.00 (m, 2H), 7.78 (s, 2H), 
               
               
                   
                 7.70 (d, J = 2.3 Hz, 1H), 7.66-7.52 (m, 4H), 7.50-7.30 (m, 3H), 7.08 (t, J = 8.7 Hz, 
               
               
                   
                 2H), 3.87 (tt, J = 7.5, 4.0 Hz, 1H), 1.24-1.09 (m, 4H). 
               
               
                 934 
                 1H NMR (400 MHz, Methanol-d4) δ 8.39 (s, 1H), 7.68 (s, 1H), 7.54 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.49 (t, J = 8.2 Hz, 1H), 7.37 (dd, J = 8.2, 1.0 Hz, 1H), 7.35-7.28 (m, 2H), 
               
               
                   
                 7.09-7.02 (m, 1H), 7.02-6.92 (m, 3H), 3.81-3.71 (m, 1H), 1.14-0.98 (m, 4H). 
               
               
                 935 
                 1H NMR (400 MHz, Methanol-d4) δ 8.45 (s, 1H), 7.70 (s, 1H), 7.57 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.34 (ddd, J = 8.7, 5.7, 3.0 Hz, 4H), 6.95 (t, J = 8.5 Hz, 3H), 6.82 (s, 1H), 3.76 (tt, 
               
               
                   
                 J = 7.4, 4.0 Hz, 1H), 3.32 (s, 3H), 1.11-1.00 (m, 4H). 
               
               
                 936 
                 1H NMR (400 MHz, Methanol-d4) δ 8.46 (s, 1H), 7.79 (s, 1H), 7.64 (d, J = 2.0 Hz, 
               
               
                   
                 1H), 7.44 (d, J = 8.5 Hz, 2H), 7.36 (d, J = 8.5 Hz, 2H), 7.00 (d, J = 2.1 Hz, 1H), 
               
               
                   
                 4.16 (d, J = 13.9 Hz, 1H), 3.87 (tt, J = 7.3, 3.6 Hz, 1H), 3.72 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 1.22-1.09 (m, 4H), 0.96 (s, 9H). 
               
               
                 937 
                 1H NMR (400 MHz, DMSO-d6) δ 8.22 (d, J = 5.5 Hz, 1H), 8.04 (d, J = 5.1 Hz, 1H), 
               
               
                   
                 7.80 (d, J = 2.2 Hz, 1H), 7.58 (ddd, J = 8.3, 5.3, 2.5 Hz, 2H), 7.43 (d, J = 8.6 Hz, 1H), 
               
               
                   
                 7.38 (d, J = 4.4 Hz, 1H), 7.31 (d, J = 2.3 Hz, 1H), 7.24 (q, J = 2.8 Hz, 2H), 7.19 (ddt, J = 8.2, 
               
               
                   
                 6.0, 3.7 Hz, 4H), 5.74-5.54 (m, 1H), 3.98 (tt, J = 7.5, 4.0 Hz, 1H), 
               
               
                   
                 2.73-2.53 (m, 2H), 2.48-2.15 (m, 2H), 1.23-1.05 (m, 4H). 
               
               
                 938 
                 1H NMR (400 MHz, DMSO-d6) δ 8.35 (d, J = 7.9 Hz, 1H), 8.24 (d, J = 5.0 Hz, 1H), 
               
               
                   
                 7.64-7.55 (m, 3H), 7.48-7.32 (m, 3H), 7.36-7.29 (m, 1H), 7.31-7.14 (m, 6H), 
               
               
                   
                 5.73-5.63 (m, 1H), 2.73-2.52 (m, 2H), 2.47-2.32 (m, 1H), 2.28-2.15 (m, 1H), 
               
               
                   
                 1.81-1.66 (m, 4H). 
               
               
                 939 
                 1H NMR (400 MHz, DMSO-d6) δ 8.28 (s, 1H), 8.03 (s, 1H), 7.61-7.41 (m, 4H), 
               
               
                   
                 7.39-7.31 (m, 4H), 7.28 (s, 4H), 5.71 (s, 1H), 4.05-3.93 (m, 1H), 2.66 (d, J = 5.3 Hz, 
               
               
                   
                 3H), 2.33 (s, 3H), 1.23-1.05 (m, 5H). 
               
               
                 940 
                 1H NMR (400 MHz, Methanol-d4) δ 8.25 (s, 1H), 8.08 (s, 1H), 8.01-7.97 (m, 1H), 
               
               
                   
                 7.92 (s, 1H), 7.85 (s, 1H), 7.75 (d, J = 2.4 Hz, 1H), 7.69 (d, J = 7.8 Hz, 1H), 7.54 (t, J = 7.8 Hz, 
               
               
                   
                 1H), 7.30 (d, J = 4.3 Hz, 1H), 7.25 (d, J = 0.9 Hz, 1H), 7.15-7.03 (m, 4H), 
               
               
                   
                 7.04-6.97 (m, 2H), 6.25 (s, 1H), 5.42 (t, J = 7.1 Hz, 1H), 3.89 (tt, J = 7.6, 4.0 Hz, 1H), 
               
               
                   
                 2.05 (dt, J = 14.1, 7.2 Hz, 1H), 1.80 (dq, J = 14.6, 7.3 Hz, 1H), 1.22-1.09 (m, 4H), 
               
               
                   
                 0.91 (t, J = 7.4 Hz, 3H). 
               
               
                 941 
                 1H NMR (400 MHz, Methanol-d4) δ 8.23 (d, J = 3.2 Hz, 2H), 8.00 (d, J = 7.9 Hz, 1H), 
               
               
                   
                 7.94 (d, J = 0.8 Hz, 1H), 7.86 (s, 1H), 7.82 (d, J = 2.4 Hz, 1H), 7.67 (d, J = 7.8 Hz, 
               
               
                   
                 1H), 7.54 (t, J = 7.8 Hz, 1H), 7.42 (d, J = 2.5 Hz, 1H), 7.36-7.28 (m, 1H), 7.26 (d, J = 0.9 Hz, 
               
               
                   
                 1H), 7.16-7.02 (m, 4H), 6.28 (s, 1H), 5.52 (t, J = 7.1 Hz, 1H), 3.94-3.83 (m, 
               
               
                   
                 1H), 2.10 (dt, J = 13.9, 7.2 Hz, 1H), 1.88 (dt, J = 14.4, 7.2 Hz, 1H), 1.24-1.12 (m, 
               
               
                   
                 4H), 0.94 (t, J = 7.3 Hz, 3H). 
               
               
                 942 
                 1H NMR (400 MHz, Methanol-d4) δ 8.26 (s, 1H), 8.06 (s, 1H), 7.84 (s, 1H), 7.82 (s, 
               
               
                   
                 1H), 7.80 (d, J = 2.5 Hz, 1H), 7.70 (d, J = 7.8 Hz, 1H), 7.47 (t, J = 7.8 Hz, 1H), 7.41 (d, 
               
               
                   
                 J = 2.6 Hz, 1H), 7.34 (d, J = 4.3 Hz, 1H), 7.30-7.18 (m, 2H), 7.17-7.08 (m, 2H), 
               
               
                   
                 6.24 (s, 1H), 5.55 (t, J = 7.2 Hz, 1H), 3.93-3.82 (m, 1H), 2.12 (dt, J = 14.4, 7.2 Hz, 1H), 
               
               
                   
                 1.95 (dt, J = 14.0, 7.1 Hz, 1H), 1.26-1.09 (m, 4H), 0.98 (t, J = 7.3 Hz, 3H). 
               
               
                 943 
                 1H NMR (400 MHz, Methanol-d4) δ 8.27 (s, 1H), 7.87 (s, 1H), 7.83 (s, 1H), 7.80 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.71 (d, J = 7.6 Hz, 1H), 7.64 (d, J = 7.6 Hz, 1H), 7.56-7.46 (m, 1H), 
               
               
                   
                 7.43 (d, J = 2.5 Hz, 1H), 7.34 (d, J = 4.4 Hz, 1H), 7.27-7.20 (m, 2H), 7.19-7.12 (m, 
               
               
                   
                 2H), 6.26 (s, 1H), 5.57 (t, J = 7.1 Hz, 1H), 4.47 (t, J = 11.7 Hz, 3H), 3.89 (tt, J = 7.3, 
               
               
                   
                 3.9 Hz, 1H), 2.12 (dq, J = 15.1, 7.5 Hz, 1H), 1.96 (dt, J = 13.8, 7.1 Hz, 1H), 
               
               
                   
                 1.26-1.10 (m, 4H), 0.99 (t, J = 7.3 Hz, 3H). 
               
               
                 944 
                 1H NMR (400 MHz, Methanol-d4) δ 8.37 (s, 1H), 8.03 (s, 1H), 7.87-7.80 (m, 2H), 
               
               
                   
                 7.66 (d, J = 7.7 Hz, 1H), 7.46 (t, J = 7.7 Hz, 1H), 7.38 (d, J = 4.2 Hz, 1H), 
               
               
                   
                 7.35-7.23 (m, 4H), 7.25-7.18 (m, 2H), 6.24 (s, 1H), 5.72 (t, J = 7.1 Hz, 1H), 3.94-3.81 (m, 1H), 
               
               
                   
                 2.19 (dt, J = 14.4, 7.3 Hz, 1H), 2.05 (dq, J = 14.0, 7.3 Hz, 1H), 1.26-1.11 (m, 4H), 
               
               
                   
                 1.00 (t, J = 7.3 Hz, 3H). 
               
               
                 945 
                 1H NMR (400 MHz, Methanol-d4) δ 8.26 (s, 1H), 7.86 (s, 1H), 7.74 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.53 (m, 1H), 7.51-7.46 (m, 1H), 7.38-7.32 (m, 3H), 7.29 (m, 3H), 
               
               
                   
                 7.26-7.21 (m, 2H), 6.52 (s, 1H), 5.75 (m, 1H), 3.92-3.88 (m, 1H), 2.60 (m, 2H), 2.44 (m, 1H), 
               
               
                   
                 2.31 (m, 1H), 1.29-1.15 (m, 4H). 
               
               
                 946 
                 1H NMR (400 MHz, Methanol-d4) δ 8.41 (s, 1H), 7.80 (s, 1H), 7.64 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.55 (dd, J = 8.1, 1.2 Hz, 1H), 7.52-7.41 (m, 3H), 7.34 (d, J = 7.5 Hz, 1H), 
               
               
                   
                 7.15-7.07 (m, 2H), 7.06 (d, J = 2.4 Hz, 1H), 3.88 (tt, J = 7.5, 3.9 Hz, 1H), 2.39 (s, 3H), 
               
               
                   
                 1.23-1.09 (m, 4H). 
               
               
                 947 
                 1H NMR (400 MHz, Methanol-d4) δ 8.47 (s, 1H), 7.75 (s, 1H), 7.64 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.46-7.37 (m, 3H), 7.33 (dd, J = 8.0, 1.4 Hz, 2H), 7.22-7.15 (m, 1H), 
               
               
                   
                 7.13-7.03 (m, 3H), 3.86 (tt, J = 7.6, 4.1 Hz, 1H), 1.19-1.11 (m, 4H). 
               
               
                 948 
                 1H NMR (400 MHz, Methanol-d4) δ 8.12 (s, 1H), 7.93 (s, 1H), 7.75 (s, 1H), 7.68 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.60 (d, J = 7.9 Hz, 1H), 7.38 (t, J = 7.7 Hz, 1H), 7.29 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.24 (d, J = 4.3 Hz, 1H), 7.21-7.07 (m, 3H), 7.02 (dd, J = 7.4, 2.3 Hz, 2H), 
               
               
                   
                 6.14 (s, 1H), 5.42 (t, J = 7.2 Hz, 1H), 3.79 (tt, J = 7.5, 4.0 Hz, 1H), 2.77 (s, 3H), 2.02 (dt, J = 14.4, 
               
               
                   
                 7.3 Hz, 1H), 1.83 (dt, J = 14.0, 7.1 Hz, 1H), 1.12-1.01 (m, 4H), 0.88 (t, J = 7.3 Hz, 
               
               
                   
                 3H). 
               
               
                 949 
                 1H NMR (400 MHz, DMSO-d6) δ 8.25 (s, 1H), 8.00 (s, 1H), 7.84 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.64-7.48 (m, 4H), 7.42-7.13 (m, 8H), 6.27 (s, 1H), 5.74-5.57 (m, 1H), 3.96 (dq, J = 7.7, 
               
               
                   
                 3.7 Hz, 1H), 2.61 (m, 2H), 2.44-2.32 (m, 1H), 2.25-2.15 (m, 1H), 
               
               
                   
                 1.23-1.00 (m, 4H). 
               
               
                 950 
                 1H NMR (400 MHz, DMSO-d6) δ 8.49 (s, 1H), 8.07 (s, 2H), 7.87-7.80 (m, 2H), 
               
               
                   
                 7.72-7.65 (m, 2H), 7.36-7.28 (m, 3H), 7.04 (t, J = 7.4 Hz, 1H), 6.93 (t, J = 7.6 Hz, 2H), 
               
               
                   
                 6.71 (d, J = 7.7 Hz, 2H), 6.56 (d, J = 2.4 Hz, 1H), 5.08 (dd, J = 9.3, 6.2 Hz, 1H), 
               
               
                   
                 3.95 (tt, J = 7.5, 3.8 Hz, 1H), 2.81-2.55 (m, 3H), 1.97 (t, J = 9.6 Hz, 1H), 1.24-1.02 (m, 
               
               
                   
                 5H). 
               
               
                 951 
                 1H NMR (400 MHz, DMSO-d6) δ 8.46 (s, 1H), 8.13 (s, 1H), 8.05 (s, 1H), 7.84 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.82-7.78 (m, 2H), 7.59-7.51 (m, 4H), 7.35 (td, J = 7.6, 1.6 Hz, 2H), 
               
               
                   
                 6.95 (t, J = 7.4 Hz, 1H), 6.77 (t, J = 7.6 Hz, 3H), 6.53 (d, J = 7.8 Hz, 3H), 6.47 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 5.06 (dd, J = 9.9, 5.9 Hz, 1H), 3.96 (tt, J = 7.5, 4.0 Hz, 1H), 2.58 (dd, J = 19.0, 
               
               
                   
                 10.0 Hz, 1H), 1.24-1.03 (m, 6H). 
               
               
                 952 
                 1H NMR (400 MHz, Methanol-d4) δ 8.36 (s, 1H), 8.15 (s, 1H), 7.77 (m, 1H), 
               
               
                   
                 7.53-7.44 (m, 2H), 7.36-7.28 (m, 2H), 7.14 (d, J = 2.5 Hz, 1H), 6.46 (s, 1H), 3.88 (d, J = 13.7 Hz, 
               
               
                   
                 1H), 3.70 (d, J = 13.7 Hz, 1H), 3.10-2.96 (m, 4H), 2.41-2.26 (m, 1H), 
               
               
                   
                 2.24-2.11 (m, 1H), 0.94 (s, 9H). 
               
               
                 953 
                 1H NMR (400 MHz, DMSO-d6) δ 8.22 (d, J = 0.6 Hz, 1H), 8.02 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 8.01 (d, J = 0.6 Hz, 1H), 7.50-7.42 (m, 2H), 7.33-7.28 (m, 2H), 7.16 (s, 1H), 7.12 (t, 
               
               
                   
                 J = 6.6 Hz, 1H), 7.00 (d, J = 2.4 Hz, 1H), 3.99-3.91 (m, 1H), 3.72 (dd, J = 13.7, 7.3 Hz, 
               
               
                   
                 1H), 3.51 (dd, J = 13.6, 5.7 Hz, 1H), 1.21-1.05 (m, 5H), 0.85 (s, 9H). 
               
               
                 954 
                 1H NMR (400 MHz, Methanol-d4) δ 8.46 (s, 1H), 7.85 (s, 1H), 7.65 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.47 (d, J = 8.4 Hz, 2H), 7.37 (d, J = 8.5 Hz, 2H), 7.02 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 6.08 (s, 1H), 4.94-4.87 (m, 6H), 4.20 (d, J = 14.0 Hz, 1H), 3.71 (dd, J = 32.8, 13.3 Hz, 
               
               
                   
                 3H), 3.55 (s, 2H), 3.29-3.14 (m, 3H), 2.43 (s, 4H), 2.37 (d, J = 12.9 Hz, 1H), 1.37 (t, 
               
               
                   
                 J = 7.3 Hz, 3H), 1.06 (d, J = 7.3 Hz, 2H), 0.95 (s, 9H). 
               
               
                 955 
                 1H NMR (400 MHz, Methanol-d4) δ 8.28 (s, 1H), 7.87 (s, 1H), 7.59 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.52 (d, J = 8.3 Hz, 2H), 7.41 (t, J = 7.8 Hz, 3H), 7.35-7.17 (m, 5H), 6.21 (s, 
               
               
                   
                 1H), 5.87-5.78 (m, 1H), 4.93 (d, J = 16.4 Hz, 6H), 4.80 (s, 1H), 3.76 (d, J = 13.0 Hz, 
               
               
                   
                 2H), 3.30-3.13 (m, 4H), 2.63 (t, J = 7.3 Hz, 2H), 2.48 (d, J = 8.8 Hz, 1H), 2.36 (d, J = 14.3 Hz, 
               
               
                   
                 3H), 1.38 (t, J = 7.3 Hz, 4H). 
               
               
                 956 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 8.16 (s, 1H), 7.75 (d, J = 2.6 Hz, 
               
               
                   
                 1H), 7.48 (m, 2H), 7.32 (m, 2H), 7.12 (d, J = 2.5 Hz, 1H), 6.43 (s, 1H), 3.88 (d, J = 13.7 Hz, 
               
               
                   
                 1H), 3.67 (d, J = 13.6 Hz, 1H), 1.99 (m, 2H), 1.95 (m, 1H), 0.94 (s, 9H). 
               
               
                 957 
                 1H NMR (400 MHz, Methanol-d4) δ 8.34 (s, 1H), 8.01 (s, 1H), 7.73 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.59-7.51 (m, 1H), 7.49-7.42 (m, 1H), 7.35-7.26 (m, 2H), 7.09 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.40 (s, 1H), 3.93 (d, J = 13.6 Hz, 1H), 3.61 (d, J = 13.6 Hz, 1H), 1.82 (m, 2H), 
               
               
                   
                 1.61 (m, 2H), 0.94 (s, 9H). 
               
               
                 958 
                 1H NMR (400 MHz, Methanol-d4) δ 8.49 (s, 1H), 7.92 (s, 1H), 7.62 (d, J = 2.3, 1H), 
               
               
                   
                 7.46 (m, 2H), 7.36-7.29 (m, 2H), 6.98 (m, 1H), 4.07 (d, J = 13.8 Hz, 1H), 3.82 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 1.54 (m, 1H), 1.22 (m, 2H), 1.02 (m, 2H), 0.98 (s, 9H), 0.57-0.48 (m, 
               
               
                   
                 2H), 0.33 (m, 2H). 
               
               
                 959 
                 1H NMR (400 MHz, Methanol-d4) δ 8.50 (s, 1H), 8.46 (m, 1H), 8.03 (s, 1H), 
               
               
                   
                 7.68-7.59 (m, 2H), 7.56-7.50 (m, 1H), 7.50-7.45 (m, 1H), 7.38-7.29 (m, 2H), 
               
               
                   
                 7.26-7.18 (m, 1H), 7.02 (d, J = 2.4 Hz, 1H), 6.55 (d, J = 8.0, 1H), 4.10 (d, J = 13.8 Hz, 1H), 
               
               
                   
                 3.79 (d, J = 13.8 Hz, 1H), 1.94 (m, 2H), 1.77 (m, 2H), 0.97 (s, 9H). 
               
               
                 960 
                 1H NMR (400 MHz, Methanol-d4) δ 8.52 (d, J = 5.3 Hz, 1H), 8.49 (s, 1H), 8.30 (s, 
               
               
                   
                 1H), 8.08 (s, 1H), 7.82-7.75 (m, 1H), 7.61 (d, J = 2.3 Hz, 1H), 7.53 (dd, J = 8.1, 5.0 Hz, 
               
               
                   
                 1H), 7.50-7.44 (m, 2H), 7.37-7.26 (m, 2H), 6.98 (m, 1H), 4.09 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 3.77 (d, J = 13.8 Hz, 1H), 1.87 (m, 2H), 1.76 (m, 2H), 0.95 (s, 9H). 
               
               
                 961 
                 1H NMR (400 MHz, Methanol-d4) δ 8.23 (d, J = 0.6 Hz, 1H), 8.09 (s, 1H), 7.78 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.61-7.49 (m, 2H), 7.47-7.31 (m, 4H), 7.31-7.22 (m, 3H), 
               
               
                   
                 7.22-7.12 (m, 2H), 6.22 (s, 1H), 5.74 (dd, J = 8.4, 5.9 Hz, 1H), 2.61 (t, J = 7.3 Hz, 2H), 2.41 (dd, 
               
               
                   
                 J = 14.4, 7.3 Hz, 1H), 2.26 (dt, J = 13.9, 6.8 Hz, 1H), 2.07-1.81 (m, 4H). 
               
               
                 962 
                 1H NMR (400 MHz, Methanol-d4) δ 8.37 (2, 1H), 7.88 (s, 1H), 7.76 (m, 1H), 7.46 (m, 
               
               
                   
                 2H), 7.36-7.27 (m, 2H), 7.12 (d, J = 2.5 Hz, 1H), 6.38 (s, 1H), 3.90 (d, J = 13.7 Hz, 
               
               
                   
                 1H), 3.72 (m, 1H), 1.65 (s, 3H), 1.34-1.28 (m, 2H), 1.09-1.03 (m, 2H), 0.94 (s, 9H). 
               
               
                 963 
                 1H NMR (400 MHz, Methanol-d4) δ 8.37 (s, 1H), 7.81 (s, 1H), 7.76 (m, 1H), 
               
               
                   
                 7.50-7.46 (m, 2H), 7.35-7.29 (m, 2H), 7.14 (d, J = 2.5 Hz, 1H), 6.41 (s, 1H), 5.15 (m, 2H), 
               
               
                   
                 3.92 (d, J = 13.7 Hz, 1H), 3.68 (d, J = 13.7 Hz, 1H), 0.95 (s, 9H). 
               
               
                 964 
                 1H NMR (400 MHz, Methanol-d4) δ 8.46 (s, 1H), 7.86 (s, 1H), 7.60 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.46 (m, 1H), 7.46 (m, 1H), 7.35-7.28 (m, 2H), 6.96 (d, J = 2.4 Hz, 1H), 4.05 (d, 
               
               
                   
                 J = 13.8 Hz, 1H), 3.81-3.77 (m, 3H), 1.32 (m, 2H), 1.20 (m, 2H), 0.98 (s, 9H). 
               
               
                 965 
                 1H NMR (400 MHz, Methanol-d4) δ 8.48 (s, 1H), 7.94 (s, 1H), 7.61 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.50 (m, 1H), 7.47 (m, 1H), 7.36-7.29 (m, 2H), 6.99 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 5.06 (dd, J = 9.6, 7.0 Hz, 2H), 4.83 (m, 2H), 4.13 (s, 2H), 4.05 (d, J = 13.8 Hz, 1H), 3.82 (d, 
               
               
                   
                 J = 13.8 Hz, 1H), 0.98 (s, 9H). 
               
               
                 966 
                 1H NMR (400 MHz, Methanol-d4) δ 8.49 (s, 1H), 7.78 (s, 1H), 7.69 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.62 (dd, J = 7.0, 2.7 Hz, 1H), 7.51-7.37 (m, 4H), 7.13 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.07 (t, J = 8.7 Hz, 2H), 3.86 (tt, J = 7.5, 4.0 Hz, 1H), 1.24-1.08 (m, 4H). 
               
               
                 967 
                 1H NMR (400 MHz, Methanol-d4) δ 8.54 (s, 1H), 7.79 (s, 1H), 7.62 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.51-7.42 (m, 2H), 7.24 (d, J = 2.3 Hz, 1H), 7.15-7.04 (m, 2H), 6.28 (t, J = 56.3 Hz, 
               
               
                   
                 1H), 3.92-3.82 (m, 1H), 1.56-1.47 (m, 2H), 1.47-1.33 (m, 2H), 1.24-1.09 (m, 
               
               
                   
                 4H). 
               
               
                 968 
                 1H NMR (400 MHz, Methanol-d4) δ 8.45 (m, 1H), 8.39 (m, 1H), 8.01 (s, 1H), 7.82 (d, 
               
               
                   
                 J = 2.6, 1H), 7.60 (m, 1H), 7.54 (dd, J = 8.6, 5.3 Hz, 2H), 7.28 (d, J = 2.5 Hz, 1H), 
               
               
                   
                 7.22 (m, 1H), 7.11 (t, J = 8.7 Hz, 2H), 6.52 (d, J = 8.0 Hz, 1H), 6.13 (s, 1H), 4.03 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 3.66 (d, J = 13.9 Hz, 1H), 1.92 (m, 2H), 1.77 (m, 2H), 0.94 (s, 9H). 
               
               
                 969 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (m, 1H), 8.02 (d, J = 0.8 Hz, 1H), 7.89 (s, 
               
               
                   
                 1H), 7.84 (d, J = 8.0 Hz, 1H), 7.79 (d, J = 2.5, 1H), 7.68 (m, 1H), 7.55 (m, 1H), 
               
               
                   
                 7.18 (m, 1H), 4.10 (d, J = 13.9 Hz, 1H), 3.51 (d, J = 13.9 Hz, 1H), 1.83 (m, 2H), 1.61 (m, 
               
               
                   
                 2H), 0.92 (s, J = 0.9 Hz, 9H). 
               
               
                 970 
                 1H NMR (400 MHz, DMSO-d6) δ 8.87 (s, 1H), 8.58 (d, J = 12.6 Hz, 2H), 8.30 (s, 1H), 
               
               
                   
                 7.68-7.48 (m, 3H), 7.43 (brs, 1H), 7.39-7.11 (m, 4H), 6.24 (d, J = 6.3 Hz, 1H), 
               
               
                   
                 3.89 (dd, J = 13.9, 7.2 Hz, 1H), 3.52 (dd, J = 13.9, 5.7 Hz, 1H), 0.87 (s, 9H). 
               
               
                 971 
                 1H NMR (400 MHz, DMSO-d6) δ 8.87 (s, 1H), 8.72 (s, 1H), 8.62 (s, 1H), 8.32 (s, 
               
               
                   
                 1H), 7.95 (d, J = 2.2 Hz, 1H), 7.84 (d, J = 7.9 Hz, 1H), 7.74 (d, J = 7.7 Hz, 1H), 
               
               
                   
                 7.66-7.47 (m, 3H), 7.10 (d, J = 2.4 Hz, 1H), 4.01 (dd, J = 14.1, 8.0 Hz, 1H), 3.40 (dd, J = 14.0, 
               
               
                   
                 5.2 Hz, 1H), 0.85 (s, 9H). 
               
               
                 972 
                 1H NMR (400 MHz, DMSO-d6) δ 8.89 (s, 1H), 8.61 (d, J = 7.8 Hz, 2H), 8.22 (d, J = 6.8 Hz, 
               
               
                   
                 1H), 7.63-7.27 (m, 7H), 7.28-7.11 (m, 5H), 6.62 (d, J = 7.9 Hz, 1H), 
               
               
                   
                 2.04 (dd, J = 14.2, 6.9 Hz, 1H), 1.88 (dt, J = 13.8, 7.0 Hz, 1H), 0.89 (t, J = 7.3 Hz, 3H). 
               
               
                 973 
                 1H NMR (400 MHz, Methanol-d4) δ 8.36 (s, 1H), 7.89 (s, 1H), 7.79 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.49 (dd, J = 8.7, 5.2 Hz, 2H), 7.22 (d, J = 2.5 Hz, 1H), 7.09 (t, J = 8.5 Hz, 2H), 
               
               
                   
                 6.05 (s, 1H), 4.01 (d, J = 14.0 Hz, 1H), 3.64 (d, J = 13.9 Hz, 1H), 1.53 (m, 1H), 
               
               
                   
                 1.21 (m 2H), 1.01 (m, 2H), 0.94 (s, 9H), 0.52 (m, 2H), 0.33 (m, 2H). 
               
               
                 974 
                 1H NMR (400 MHz, Methanol-d4) δ 8.59 (d, J = 5.1 Hz, 1H), 8.43 (s, 1H), 8.33 (s, 
               
               
                   
                 1H), 8.05 (s, 1H), 7.94 (m, 1H), 7.75 (dd, J = 2.4, 0.7 Hz, 1H), 7.66 (d, J = 8.2 Hz, 
               
               
                   
                 1H), 7.50 (dd, J = 8.6, 5.3 Hz, 2H), 7.21 (d, J = 2.5 Hz, 1H), 7.09 (t, J = 8.6 Hz, 2H), 
               
               
                   
                 6.08 (s, 1H), 3.99 (d, J = 13.8 Hz, 1H), 3.58 (d, J = 13.8 Hz, 1H), 1.89 (m, 2H), 
               
               
                   
                 1.79 (m, 2H), 0.92 (s, 9H). 
               
               
                 975 
                 1H NMR (400 MHz, Methanol-d4) δ 8.31 (d, J = 0.7 Hz, 1H), 7.89 (s, 1H), 7.76 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.53 (s, 1H), 7.51 (s, 1H), 7.36 (m, 2H), 7.29 (m, 1H), 7.21 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.06 (s, 1H), 4.03 (d, J = 13.8 Hz, 1H), 3.54 (d, J = 13.8 Hz, 1H), 1.81 (m, 2H), 
               
               
                   
                 1.60 (m, 2H), 0.93 (s, 9H). 
               
               
                 976 
                 1H 1.NMR (400 MHz, Methanol-d4) δ 8.28 (d, J = 0.7 Hz, 1H), 8.10 (d, J = 0.8 Hz, 
               
               
                   
                 1H), 7.75 (dd, J = 2.5, 0.7 Hz, 1H), 7.50 (dd, J = 8.7, 5.2 Hz, 2H), 7.18 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.10 (t, J = 8.7 Hz, 2H), 6.08 (s, 1H), 3.93 (d, J = 13.8 Hz, 1H), 3.58 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 2.02-1.95 (m, 2H), 1.95-1.88 (m, 2H), 0.96-0.86 (m, 9H). 
               
               
                 977 
                 1H NMR (400 MHz, Methanol-d4) δ 8.36 (s, 1H), 7.93 (s, 1H), 7.78 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.53 (dd, J = 8.7, 5.3 Hz, 2H), 7.21 (d, J = 2.5 Hz, 1H), 7.09 (t, J = 8.7 Hz, 2H), 
               
               
                   
                 6.07 (s, 1H), 4.08 (d, J = 13.9 Hz, 1H), 3.56 (d, J = 13.9 Hz, 1H), 1.85-1.76 (m, 2H), 
               
               
                   
                 1.60 (m, 2H), 0.94 (s, 9H). 
               
               
                 978 
                 1H NMR (400 MHz, Methanol-d4) δ 8.33 (d, J = 0.7 Hz, 1H), 7.84 (s, 1H), 7.77 (dd, J = 2.4, 
               
               
                   
                 0.7 Hz, 1H), 7.48 (dd, J = 8.6, 5.3 Hz, 2H), 7.19 (d, J = 2.5 Hz, 1H), 7.09 (t, J = 8.6 Hz, 
               
               
                   
                 2H), 6.03 (s, 1H), 3.97 (d, J = 13.9 Hz, 1H), 3.63 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 1.70-1.60 (s, 3H), 1.34-1.26 (m, 2H), 1.10-0.98 (m, 2H), 0.93 (s, 9H). 
               
               
                 979 
                 1H NMR (400 MHz, Methanol-d4) δ 8.33 (s, 1H), 7.83 (s, 1H), 7.77 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.50 (dd, J = 8.4, 5.4 Hz, 2H), 7.20 (d, J = 2.6 Hz, 1H), 7.09 (t, J = 8.6 Hz, 2H), 
               
               
                   
                 6.05 (s, 1H), 4.01 (d, J = 13.9 Hz, 1H), 3.76 (d, J = 2.0 Hz, 2H), 3.59 (s, 1H), 1.30 (m, 
               
               
                   
                 2H), 1.20 (m, 2H), 0.94 (d, 9H). 
               
               
                 980 
                 1H NMR (400 MHz, Methanol-d4) δ 8.44 (s, 1H), 7.85 (s, 1H), 7.62 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.45 (d, J = 8.5 Hz, 2H), 7.36 (d, J = 8.5 Hz, 2H), 6.99 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 4.15 (d, J = 13.9 Hz, 1H), 4.07 (s, 1H), 3.73 (s, 2H), 3.67 (d, J = 13.9 Hz, 1H), 2.82 (s, 1H), 
               
               
                   
                 2.72 (s, 2H), 0.95 (s, 13H). 
               
               
                 981 
                 1H NMR (400 MHz, Methanol-d4) δ 8.37 (d, J = 2.5 Hz, 1H), 8.31-8.21 (m, 1H), 
               
               
                   
                 7.99-7.88 (m, 1H), 7.85 (d, J = 7.2 Hz, 1H), 7.56 (m, 1H), 7.47-7.19 (m, 7H), 
               
               
                   
                 7.00 (m, 1H), 5.80 (m, 1H), 3.87-3.73 (m, 1H), 2.47 (m, 3H), 2.28-2.06 (m, 1H), 
               
               
                   
                 1.82-1.54 (m, 2H), 1.26-1.00 (m, 4H). 
               
               
                 982 
                 1H NMR (400 MHz, Methanol-d4) δ 8.45 (s, 1H), 7.86 (s, 1H), 7.63 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.47 (d, J = 8.5 Hz, 2H), 7.36 (d, J = 8.4 Hz, 2H), 7.01 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 4.87-4.83 (m, 1H), 4.19 (d, J = 13.9 Hz, 1H), 3.78 (s, 2H), 3.66 (d, J = 13.9 Hz, 1H), 3.42 (s, 
               
               
                   
                 2H), 2.87 (s, 1H), 2.41 (s, 4H), 1.05-0.96 (m, 4H), 0.95 (s, 9H). 
               
               
                 983 
                 1H NMR (400 MHz, Methanol-d4) δ 8.64 (m, 2H), 8.31 (s, 1H), 8.09 (s, 1H), 7.77 (m, 
               
               
                   
                 1H), 7.55 (m, 2H), 7.25 (m, 1H), 7.17 (m, 2H), 7.11 (t, J = 8.6 Hz, 2H), 6.14 (s, 1H), 
               
               
                   
                 3.98 (d, J = 13.8 Hz, 1H), 3.58 (d, J = 13.8 Hz, 1H), 2.16 (m, 2H), 2.03 (m, 2H), 
               
               
                   
                 0.93 (s, 9H). 
               
               
                 984 
                 1H NMR (400 MHz, Methanol-d4) δ 8.52 (m, 1H), 8.42 (d, J = 2.6 Hz, 1H), 8.38 (s, 
               
               
                   
                 1H), 8.08 (s, 1H), 7.84-7.79 (m, 1H), 7.63 (s, 1H), 7.55 (dd, J = 8.5, 5.3 Hz, 2H), 
               
               
                   
                 7.27 (d, J = 2.5 Hz, 1H), 7.11 (t, J = 8.6 Hz, 2H), 6.15 (s, 1H), 4.02 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 3.65 (d, J = 13.8 Hz, 1H), 1.98 (m, 1H), 1.86 (m, 1H), 0.97-0.89 (s, 9H). 
               
               
                 985 
                 1H NMR (400 MHz, Methanol-d4) δ 8.38 (s, 1H), 7.83 (s, 1H), 7.80 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.51 (dd, J = 8.5, 5.3 Hz, 2H), 7.23 (d, J = 2.5 Hz, 1H), 7.09 (t, J = 8.6 Hz, 2H), 
               
               
                   
                 6.09 (s, 1H), 4.05 (d, J = 13.9 Hz, 1H), 3.63 (d, J = 13.9 Hz, 1H), 2.98-2.88 (m, 2H), 
               
               
                   
                 2.88-2.76 (m, 2H), 2.18-1.97 (m, 2H), 0.99-0.88 (s, 9H). 
               
               
                 986 
                 1H NMR (400 MHz, DMSO-d6) δ 8.27 (s, 1H), 7.96 (s, 1H), 7.64 (d, J = 2.1 Hz, 1H), 
               
               
                   
                 7.53 (d, J = 7.2 Hz, 2H), 7.47-7.20 (m, 10H), 7.08 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 6.26-6.00 (m, 2H), 3.94 (tt, J = 7.5, 3.9 Hz, 1H), 3.85-3.57 (m, 2H), 1.22-0.99 (m, 4H). 
               
               
                 987 
                 1H NMR (400 MHz, Methanol-d4) δ 9.05 (d, J = 5.0 Hz, 1H), 8.36 (d, J = 0.7 Hz, 1H), 
               
               
                   
                 8.07 (s, 1H), 7.83-7.75 (m, 1H), 7.56 (m, 3H), 7.25 (d, J = 2.5 Hz, 1H), 7.11 (t, J = 8.5 Hz, 
               
               
                   
                 2H), 6.97-6.89 (m, 1H), 6.13 (s, 1H), 4.03 (d, J = 13.9 Hz, 1H), 3.61 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 2.13-2.03 (m, 2H), 1.94 (m, 2H), 0.99-0.88 (s, 9H). 
               
               
                 988 
                 1H NMR (400 MHz, DMSO-d6) δ 8.32 (s, 1H), 8.26 (s, 1H), 7.93 (s, 1H), 
               
               
                   
                 7.81-7.77 (m, 1H), 7.54 (dd, J = 8.5, 5.5 Hz, 2H), 7.36 (s, 1H), 7.29 (d, J = 19.4 Hz, 1H), 
               
               
                   
                 7.19-7.10 (m, 3H), 5.92 (s, 1H), 4.57-4.46 (m, 1H), 4.39 (dd, J = 14.0, 7.1 Hz, 1H), 
               
               
                   
                 4.13 (s, 1H), 4.01-3.90 (m, 1H), 3.42 (dd, J = 14.0, 5.3 Hz, 1H), 3.10-3.05 (m, 1H), 
               
               
                   
                 2.74-2.69 (m, 1H), 1.24 (s, 9H), 0.88 (s, 9H). 
               
               
                 989 
                 1H NMR (400 MHz, Methanol-d4) δ 8.49 (s, 1H), 8.09 (s, 1H), 7.66 (m, 1H), 7.49 (dd, 
               
               
                   
                 J = 8.6, 5.2 Hz, 2H), 7.11 (t, J = 8.7 Hz, 2H), 7.05 (d, J = 2.3 Hz, 1H), 6.09 (s, 1H), 
               
               
                   
                 4.17 (d, J = 14.0 Hz, 1H), 3.76 (d, J = 13.9 Hz, 1H), 2.04-1.86 (m, 4H), 0.98 (s, 9H). 
               
               
                 990 
                 1H NMR (400 MHz, Methanol-d4) δ 8.47 (s, 1H), 7.82 (s, 1H), 7.64 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.47 (dd, J = 8.5, 5.3 Hz, 2H), 7.09 (t, J = 8.6 Hz, 2H), 7.01 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 6.04 (s, 1H), 4.15 (d, J = 13.9 Hz, 1H), 3.75 (d, J = 14.0 Hz, 1H), 1.64 (s, 3H), 1.29 (m, 
               
               
                   
                 2H), 1.08-1.03 (m, 2H), 0.97 (s, 9H). 
               
               
                 991 
                 1H NMR (400 MHz, Methanol-d4) δ 8.50 (s, 1H), 8.48-8.43 (m, 1H), 7.98 (s, 1H), 
               
               
                   
                 7.67 (d, J = 2.3 Hz, 1H), 7.62 (m, 1H), 7.52 (dd, J = 8.5, 5.2 Hz, 2H), 7.25-7.19 (m, 
               
               
                   
                 1H), 7.16-7.06 (m, 3H), 6.55 (d, J = 8.0 Hz, 1H), 6.13 (s, 1H), 4.19 (d, J = 14.0 Hz, 
               
               
                   
                 1H), 3.75 (d, J = 14.0 Hz, 1H), 1.92 (m, 2H), 1.76 (m, 2H), 0.97 (s, 9H). 
               
               
                 992 
                 1H NMR (400 MHz, Methanol-d4) δ 8.47 (s, 1H), 7.81 (s, 1H), 7.66-7.62 (m, 1H), 
               
               
                   
                 7.50 (dd, J = 8.5, 5.2 Hz, 2H), 7.10 (t, J = 8.6 Hz, 2H), 7.03 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 6.09 (s, 1H), 4.18 (d, J = 13.9 Hz, 1H), 3.72 (d, J = 14.0 Hz, 1H), 2.99-2.88 (m, 2H), 
               
               
                   
                 2.83 (m, 2H), 2.17-1.97 (m, 2H), 0.97 (s, 9H). 
               
               
                 994 
                 1H NMR (400 MHz, DMSO-d6) δ 9.17-9.11 (m, 1H), 8.78 (d, J = 0.9 Hz, 1H), 
               
               
                   
                 8.73-8.66 (m, 1H), 8.37-8.29 (m, 2H), 7.85 (dd, J = 2.5, 0.9 Hz, 1H), 7.69-7.55 (m, 
               
               
                   
                 3H), 7.59-7.51 (m, 2H), 7.41 (d, J = 2.3 Hz, 1H), 7.23-7.14 (m, 2H), 3.86 (dd, J = 14.0, 
               
               
                   
                 7.5 Hz, 1H), 3.50 (dd, J = 14.0, 5.8 Hz, 1H), 0.82 (s, 9H). 
               
               
                 995 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 8.14 (s, 1H), 7.79 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.66 (dd, J = 7.8, 1.3 Hz, 1H), 7.62 (d, J = 8.0 Hz, 1H), 7.35 (t, J = 7.8 Hz, 1H), 
               
               
                   
                 7.01 (d, J = 2.5 Hz, 1H), 6.30 (s, 1H), 3.95 (d, J = 13.8 Hz, 1H), 3.60 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 2.58 (s, 3H), 1.84-1.60 (m, 4H), 0.88 (s, 9H). 
               
               
                 996 
                 1H NMR (400 MHz, Methanol-d4) δ 8.41 (s, 1H), 7.92 (s, 1H), 7.60 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.52 (dd, J = 8.4, 5.2 Hz, 2H), 7.09 (t, J = 8.7 Hz, 2H), 6.97 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 6.06 (s, 1H), 4.17 (d, J = 13.9 Hz, 1H), 3.63 (d, J = 13.8 Hz, 1H), 1.82 (m, 2H), 
               
               
                   
                 1.62-1.57 (m, 2H), 0.96 (s, 9H). 
               
               
                 997 
                 1H NMR (400 MHz, Methanol-d4) δ 8.53-8.45 (m, 2H), 8.28 (s, 1H), 8.01 (s, 1H), 
               
               
                   
                 7.73 (d, J = 8.2 Hz, 1H), 7.67-7.61 (m, 1H), 7.47 (m, 3H), 7.09 (t, J = 8.6 Hz, 2H), 
               
               
                   
                 7.03 (d, J = 2.3 Hz, 1H), 6.08 (s, 1H), 4.17 (d, J = 14.0 Hz, 1H), 3.72 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 1.84 (m, 2H), 1.74 (m, 2H), 0.95 (s, 9H). 
               
               
                 998 
                 1H NMR (400 MHz, Methanol-d4) δ 8.44 (s, 1H), 7.95 (s, 1H), 7.64 (m, 1H), 7.50 (m, 
               
               
                   
                 2H), 7.11 (t, J = 8.6 Hz, 2H), 7.04 (m, 1H), 6.11 (s, 1H), 4.12 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 3.75 (d, J = 13.9 Hz, 1H), 2.93 (t, J = 8.0 Hz, 4H), 2.25-2.02 (m, 2H), 0.97 (s, 9H). 
               
               
                 999 
                 1H NMR (400 MHz, DMSO-d6) δ 8.37 (s, 1H), 8.10 (s, 1H), 7.73 (s, 1H), 7.53 (dd, J = 5.9, 
               
               
                   
                 3.6 Hz, 1H), 7.48-7.15 (m, 5H), 6.90 (s, 1H), 6.59 (s, 1H), 6.33 (d, J = 6.4 Hz, 
               
               
                   
                 1H), 3.83 (dd, J = 13.7, 7.4 Hz, 1H), 3.55 (dd, J = 13.7, 5.7 Hz, 1H), 1.75-1.61 (m, 
               
               
                   
                 2H), 1.47 (q, J = 5.1 Hz, 2H), 0.87 (s, 9H). 
               
               
                 1000 
                 1H NMR (400 MHz, DMSO-d6) δ 8.37 (s, 1H), 8.32 (s, 1H), 7.50-7.15 (m, 5H), 
               
               
                   
                 6.87 (s, 1H), 6.37 (d, J = 7.2 Hz, 1H), 3.65 (m, 4H), 2.02 (d, J = 3.2 Hz, 2H), 
               
               
                   
                 1.95-1.81 (m, 2H), 0.85 (s, 9H). 
               
               
                 1001 
                 1H NMR (400 MHz, DMSO-d6) δ 8.87 (s, 1H), 8.59 (s, 1H), 8.27 (s, 1H), 
               
               
                   
                 7.53-7.28 (m, 4H), 7.20 (d, J = 12.7 Hz, 1H), 6.90 (s, 1H), 6.45 (d, J = 7.6 Hz, 1H), 3.73 (dd, J = 13.7, 
               
               
                   
                 7.2 Hz, 1H), 3.58 (dd, J = 13.8, 5.9 Hz, 1H), 0.85 (s, 9H). 
               
               
                 1002 
                 1H NMR (400 MHz, Methanol-d4) δ 8.48 (s, 1H), 7.78 (s, 1H), 7.69-7.64 (m, 1H), 
               
               
                   
                 7.49 (dd, J = 8.6, 5.3 Hz, 2H), 7.10 (t, J = 8.7 Hz, 1H), 7.07 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 6.41-6.11 (m, 1H), 6.10 (s, 1H), 4.89-4.80 (m, 2H), 4.17 (d, J = 14.0 Hz, 1H), 3.75 (d, J = 14.0 Hz, 
               
               
                   
                 1H), 0.97 (s, 9H). 
               
               
                 1003 
                 1H NMR (400 MHz, Methanol-d4) δ 8.48 (s, 1H), 8.11-8.04 (m, 1H), 7.99-7.90 (m, 
               
               
                   
                 1H), 7.87 (d, J = 8.3 Hz, 1H), 7.69 (s, 1H), 7.66 (d, J = 2.3 Hz, 1H), 7.57-7.47 (m, 
               
               
                   
                 3H), 7.48-7.39 (m, 1H), 6.91 (d, J = 2.3 Hz, 1H), 6.80 (s, 1H), 3.96 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 3.88-3.78 (m, 1H), 3.68 (d, J = 13.9 Hz, 1H), 1.19-1.05 (m, 4H), 0.70 (s, 9H). 
               
               
                 1004 
                 1H NMR (400 MHz, DMSO-d6) δ 9.14 (d, J = 2.5 Hz, 1H), 8.81 (d, J = 0.5 Hz, 1H), 
               
               
                   
                 8.68 (dd, J = 4.8, 1.4 Hz, 1H), 8.38-8.28 (m, 1H), 8.32 (s, 1H), 7.84 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.68-7.60 (m, 1H), 7.55-7.43 (m, 3H), 7.41-7.31 (m, 3H), 4.67 (s, 1H), 
               
               
                   
                 3.69-3.55 (m, 2H), 0.76 (s, 9H) 
               
               
                 1005 
                 1H NMR (400 MHz, DMSO-d6) δ 8.84 (d, J = 0.6 Hz, 1H), 8.70 (dd, J = 4.7, 1.5 Hz, 
               
               
                   
                 1H), 8.37-8.29 (m, 2H), 7.99 (t, J = 1.7 Hz, 1H), 7.93-7.84 (m, 2H), 7.81-7.74 (m, 
               
               
                   
                 1H), 7.73-7.61 (m, 2H), 7.62-7.52 (m, 2H), 7.39 (d, J = 2.5 Hz, 1H), 3.98 (dd, J = 14.0, 
               
               
                   
                 8.1 Hz, 1H), 3.39 (dd, J = 14.0, 5.2 Hz, 1H), 1.23 (s, 2H), 0.82 (s, 9H) 
               
               
                 1006 
                 1H NMR (400 MHz, DMSO-d6) δ 8.30 (d, J = 0.9 Hz, 1H), 8.10 (d, J = 1.0 Hz, 1H), 
               
               
                   
                 7.82 (dd, J = 2.5, 1.0 Hz, 1H), 7.58-7.46 (m, 4H), 7.39 (d, J = 2.5 Hz, 1H), 7.13 (td, J = 8.9, 
               
               
                   
                 1.0 Hz, 2H), 4.74 (s, 1H), 4.61 (s, 1H), 3.95 (dd, J = 14.0, 7.9 Hz, 1H), 3.42 (dd, 
               
               
                   
                 J = 13.9, 5.4 Hz, 1H), 1.40 (t, J = 6.8 Hz, 2H), 1.33 (s, 2H), 0.90-0.85 (m, 9H) 
               
               
                 1007 
                 1H NMR (400 MHz, DMSO-d6) δ 8.32 (d, J = 0.9 Hz, 1H), 8.21 (s, 1H), 7.94 (t, J = 1.7 Hz, 
               
               
                   
                 1H), 7.87-7.80 (m, 2H), 7.73 (dd, J = 7.5, 1.3 Hz, 1H), 7.61 (s, 1H), 7.53 (t, J = 7.7 Hz, 
               
               
                   
                 2H), 7.35 (d, J = 2.5 Hz, 1H), 4.75 (s, 1H), 4.63 (s, 1H), 4.04 (dd, J = 14.0, 
               
               
                   
                 8.3 Hz, 1H), 3.34 (dd, J = 14.0, 5.1 Hz, 1H), 1.46-1.39 (m, 2H), 1.36-1.31 (m, 2H), 
               
               
                   
                 0.85 (s, 9H) 
               
               
                 1008 
                 1H NMR (400 MHz, Methanol-d4) δ 8.51 (s, 1H), 7.98 (s, 1H), 7.67 (t, J = 8.2 Hz, 
               
               
                   
                 2H), 7.63 (d, J = 2.3 Hz, 1H), 7.34 (t, J = 7.8 Hz, 1H), 6.79 (d, J = 2.3 Hz, 1H), 6.26 (s, 
               
               
                   
                 1H), 4.20 (d, J = 13.9 Hz, 1H), 3.65 (d, J = 13.8 Hz, 1H), 2.59 (s, 3H), 1.87-1.77 (m, 
               
               
                   
                 2H), 1.68-1.58 (m, 2H), 0.92 (s, 9H). 
               
               
                 1009 
                 1H NMR (400 MHz, Methanol-d4) δ 8.50 (s, 1H), 7.87 (s, 1H), 7.70-7.61 (m, 3H), 
               
               
                   
                 7.34 (t, J = 7.8 Hz, 1H), 6.82 (d, J = 2.3 Hz, 1H), 6.27 (s, 1H), 4.15 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 3.70 (d, J = 13.9 Hz, 1H), 2.97-2.79 (m, 4H), 2.58 (s, 3H), 2.17-2.00 (m, 2H), 
               
               
                   
                 0.92 (s, 9H). 
               
               
                 1010 
                 1H NMR (400 MHz, Methanol-d4) δ 8.46 (s, 1H), 7.96 (s, 1H), 7.64 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.47 (d, J = 8.5 Hz, 2H), 7.36 (d, J = 8.5 Hz, 2H), 7.02 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 4.20 (d, J = 13.9 Hz, 1H), 3.83-3.73 (m, 6H), 3.67 (d, J = 14.0 Hz, 1H), 2.72-2.58 (m, 
               
               
                   
                 6H), 0.96 (s, 9H). 
               
               
                 1011 
                 1H NMR (400 MHz, Methanol-d4) δ 8.62 (d, J = 6.1 Hz, 2H), 8.32 (s, 1H), 8.13 (s, 
               
               
                   
                 1H), 7.75 (d, J = 2.5 Hz, 1H), 7.61-7.56 (m, 1H), 7.50-7.43 (m, 1H), 
               
               
                   
                 7.37-7.29 (m, 2H), 7.17 (d, J = 6.0 Hz, 2H), 7.11 (d, J = 2.5 Hz, 1H), 6.46 (s, 1H), 3.89 (d, J = 13.6 Hz, 
               
               
                   
                 1H), 3.58 (d, J = 13.5 Hz, 1H), 2.18-2.11 (m, 2H), 2.04 (m, 2H), 0.93 (s, 
               
               
                   
                 9H). 
               
               
                 1012 
                 1H NMR (400 MHz, Methanol-d4) δ 8.47 (s, 1H), 7.97 (s, 1H), 7.67 (d, J = 7.6 Hz, 
               
               
                   
                 1H), 7.64 (d, J = 2.3 Hz, 1H), 7.61 (d, J = 8.0 Hz, 1H), 7.35 (t, J = 7.8 Hz, 1H), 6.82 (d, 
               
               
                   
                 J = 2.3 Hz, 1H), 6.28 (s, 1H), 5.94 (t, J = 54.6 Hz, 1H), 4.09 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 3.72 (d, J = 13.9 Hz, 1H), 2.57 (s, 3H), 1.53 (s, 4H), 0.92 (s, 9H). 
               
               
                 1013 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 7.98 (s, 1H), 7.79 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.64 (dd, J = 11.6, 7.8 Hz, 2H), 7.34 (t, J = 7.9 Hz, 1H), 6.99 (d, J = 2.6 Hz, 1H), 
               
               
                   
                 6.28 (s, 1H), 5.95 (t, J = 54.7 Hz, 1H), 3.94 (d, J = 13.7 Hz, 1H), 3.59 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 2.58 (s, 3H), 1.53 (s, 4H), 0.88 (s, 9H). 
               
               
                 1014 
                 1H NMR (400 MHz, Methanol-d4) δ 8.33 (s, 1H), 7.88 (s, 1H), 7.76-7.72 (m, 1H), 
               
               
                   
                 7.54-7.49 (m, 1H), 7.47 (d, J = 8.1 Hz, 1H), 7.32 (dd, J = 6.8, 3.3 Hz, 2H), 7.11 (s, 
               
               
                   
                 1H), 6.42 (s, 1H), 3.89 (d, J = 13.6 Hz, 1H), 3.64 (d, J = 13.6 Hz, 1H), 2.93 (s, 2H), 
               
               
                   
                 2.84 (m, 2H), 2.17-1.98 (m, 2H), 0.94 (s, 9H). 
               
               
                 1015 
                 1H NMR (400 MHz, DMSO-d6) δ 8.42 (s, 1H), 7.99 (s, 1H), 7.43 (dt, J = 5.7, 2.7 Hz, 
               
               
                   
                 3H), 7.35-7.19 (m, 3H), 6.89 (s, 1H), 6.32 (d, J = 5.7 Hz, 1H), 3.99-3.89 (m, 1H), 
               
               
                   
                 3.81 (dd, J = 13.7, 7.3 Hz, 1H), 3.61 (dd, J = 13.7, 5.8 Hz, 1H), 1.21-0.99 (m, 4H), 
               
               
                   
                 0.86 (s, 9H). 
               
               
                 1016 
                 1H NMR (400 MHz, DMSO-d6) δ 8.58 (t, J = 4.5 Hz, 1H), 8.34 (d, J = 4.6 Hz, 1H), 
               
               
                   
                 8.23 (s, 1H), 8.05-8.01 (m, 1H), 7.79-7.72 (m, 1H), 7.64 (q, J = 2.3 Hz, 1H), 
               
               
                   
                 7.48 (dq, J = 8.8, 3.3, 2.2 Hz, 2H), 7.41-7.27 (m, 2H), 7.22-7.12 (m, 2H), 6.96 (d, J = 3.1 Hz, 
               
               
                   
                 1H), 4.31 (d, J = 14.6 Hz, 1H), 4.02-3.88 (m, 2H), 1.35 (t, J = 5.1 Hz, 6H), 
               
               
                   
                 1.20-1.05 (m, 4H). 
               
               
                 1017 
                 1H NMR (400 MHz, Methanol-d4) δ 8.52 (s, 1H), 8.10 (s, 1H), 7.55-7.41 (m, 2H), 
               
               
                   
                 7.41-7.24 (m, 3H), 6.88 (s, 1H), 6.44 (s, 1H), 4.05 (d, J = 13.8 Hz, 1H), 3.82 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 1.71 (d, J = 33.6 Hz, 4H), 0.98 (s, 9H). 
               
               
                 1018 
                 1H NMR (400 MHz, DMSO-d6) δ 8.37-8.27 (m, 2H), 7.84 (dd, J = 16.5, 2.3 Hz, 
               
               
                   
                 1H), 7.59-7.47 (m, 2H), 7.44 (d, J = 2.4 Hz, 1H), 7.34 (d, J = 2.6 Hz, 1H), 7.23 (t, J = 8.6 Hz, 
               
               
                   
                 1H), 7.14 (t, J = 8.7 Hz, 1H), 6.73 (dd, J = 47.4, 10.1 Hz, 1H), 4.59-4.47 (m, 
               
               
                   
                 1H), 1.83-1.55 (m, 10H), 0.93 (d, J = 24.4 Hz, 3H), 0.80 (d, J = 43.1 Hz, 3H). 
               
               
                 1020 
                 1H NMR (400 MHz, Methanol-d4) δ 8.34 (s, 1H), 7.91 (s, 1H), 7.75 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.54-7.48 (m, 1H), 7.48-7.44 (m, 1H), 7.35-7.28 (m, 2H), 7.11 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.40 (s, 1H), 3.90 (d, J = 13.7 Hz, 1H), 3.65 (d, J = 13.7 Hz, 1H), 2.67 (m, 
               
               
                   
                 2H), 2.54-2.42 (m, 1H), 1.90 (m, 2H), 1.62 (m, 2H), 0.94 (s, 9H). 
               
               
                 1021 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 7.94 (s, 1H), 7.75 (s, 1H), 7.50 (m, 
               
               
                   
                 1H), 7.48-7.43 (m, 1H), 7.35-7.27 (m, 2H), 7.12 (s, 1H), 6.41 (s, 1H), 3.91 (d, J = 13.6 Hz, 
               
               
                   
                 1H), 3.67 (d, J = 13.6 Hz, 1H), 1.90 (s, 6H), 0.95 (s, 9H). 
               
               
                 1022 
                 1H NMR (400 MHz, Methanol-d4) δ 8.36 (s, 1H), 8.03 (s, 1H), 7.75 (s, 1H), 7.51 (m, 
               
               
                   
                 1H), 7.47 (m, 1H), 7.32 (m, 2H), 7.13 (s, 1H), 6.42 (s, 1H), 4.52 (dd, J = 10.0, 6.8 Hz, 
               
               
                   
                 1H), 4.36 (dd, J = 10.0, 3.5 Hz, 1H), 4.10 (td, J = 8.7, 4.6 Hz, 1H), 3.97-3.86 (m, 
               
               
                   
                 2H), 3.65 (d, J = 13.6 Hz, 1H), 3.09-2.97 (m, 1H), 2.86 (m, 1H), 0.95 (s, 9H). 
               
               
                 1023 
                 1H NMR (400 MHz, Methanol-d4) δ 8.37 (s, 1H), 7.99 (s, 1H), 7.77 (s, 1H), 7.48 (m, 
               
               
                   
                 2H), 7.38-7.27 (m, 2H), 7.14 (s, 1H), 6.43 (s, 1H), 3.93 (d, J = 13.6 Hz, 1H), 3.81 (m, 
               
               
                   
                 2H), 3.67 (d, J = 13.7 Hz, 1H), 3.47 (m, 2H), 2.56 (m, 4H), 0.95 (s, 9H). 
               
               
                 1024 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 8.06 (s, 1H), 7.76 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.30-7.13 (m, 4H), 7.08 (d, J = 2.5 Hz, 1H), 6.22 (s, 1H), 3.82 (d, J = 13.7 Hz, 
               
               
                   
                 1H), 3.73 (d, J = 13.7 Hz, 1H), 2.40 (s, 3H), 2.02-1.86 (m, 4H), 0.91 (s, 9H). 
               
               
                 1025 
                 1H NMR (400 MHz, Methanol-d4) δ 8.34 (s, 1H), 8.11 (s, 1H), 7.75 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.68 (d, J = 7.6 Hz, 1H), 7.59 (d, J = 7.8 Hz, 1H), 7.56-7.42 (m, 2H), 7.16 (t, J = 56.0 Hz, 
               
               
                   
                 1H), 7.15 (s, 1H), 6.41 (s, 1H), 3.81 (d, J = 13.8 Hz, 1H), 3.76 (d, J = 13.7 Hz, 
               
               
                   
                 1H), 2.05-1.79 (m, 4H), 0.94 (s, 9H). 
               
               
                 1026 
                 1H NMR (400 MHz, Methanol-d4) δ 8.32 (s, 1H), 8.05 (d, J = 0.6 Hz, 1H), 7.79 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.60 (d, J = 8.1 Hz, 1H), 7.53 (d, J = 2.6 Hz, 1H), 7.42-7.22 (m, 3H), 
               
               
                   
                 6.44 (s, 1H), 5.03 (d, J = 11.5 Hz, 1H), 4.62 (d, J = 11.5 Hz, 1H), 4.14 (d, J = 14.1 Hz, 
               
               
                   
                 1H), 3.51 (d, J = 14.1 Hz, 1H), 2.06-1.79 (m, 4H), 0.93 (s, 9H). 
               
               
                 1027 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 8.28 (s, 1H), 7.81 (d, J = 7.8 Hz, 
               
               
                   
                 2H), 7.78 (d, J = 2.5 Hz, 1H), 7.49 (t, J = 7.8 Hz, 1H), 7.04 (d, J = 2.6 Hz, 1H), 3.94 (d, 
               
               
                   
                 J = 13.7 Hz, 1H), 3.57 (d, J = 13.6 Hz, 1H), 2.06-1.87 (m, 4H), 0.92 (s, 9H). 
               
               
                 1028 
                 1H NMR (400 MHz, DMSO-d6) δ 8.23 (d, J = 4.3 Hz, 1H), 8.16 (d, J = 7.9 Hz, 1H), 
               
               
                   
                 7.63-7.54 (m, 3H), 7.46-7.31 (m, 3H), 7.31-7.11 (m, 7H), 6.13 (t, J = 54.0 Hz, 
               
               
                   
                 1H), 5.49 (q, J = 7.5 Hz, 1H), 2.14 (dt, J = 14.2, 7.2 Hz, 1H), 1.92 (dt, J = 13.9, 7.0 Hz, 
               
               
                   
                 1H), 1.51 (s, 4H), 1.00-0.86 (m, 3H). 
               
               
                 1029 
                 1H NMR (400 MHz, DMSO-d6) δ 8.31 (d, J = 0.7 Hz, 1H), 8.04 (d, J = 0.8 Hz, 1H), 
               
               
                   
                 7.81 (d, J = 2.4 Hz, 1H), 7.51-7.38 (m, 3H), 7.35-7.26 (m, 3H), 5.34 (s, 1H), 
               
               
                   
                 3.75 (dd, J = 13.7, 7.4 Hz, 1H), 3.53 (dd, J = 13.7, 5.7 Hz, 1H), 1.58 (d, J = 0.7 Hz, 9H), 
               
               
                   
                 0.86 (s, 9H). 
               
               
                 1030 
                 1H NMR (400 MHz, DMSO-d6) δ 8.37 (s, 1H), 8.30 (s, 1H), 7.78 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 7.49-7.42 (m, 2H), 7.40 (m, 2H), 7.36-7.27 (m, 3H), 3.69 (dd, J = 13.8, 7.2 Hz, 
               
               
                   
                 1H), 3.56 (dd, J = 14.1, 6.2 Hz, 1H), 2.07-1.99 (m, 2H), 1.94-1.86 (m, 2H), 0.83 (s, 
               
               
                   
                 9H). 
               
               
                 1031 
                 1H NMR (400 MHz, Methanol-d4) δ 9.08 (s, 1H), 8.47 (s, 1H), 8.15 (s, 1H), 7.96 (d, J = 1.8 Hz, 
               
               
                   
                 1H), 7.86 (s, 1H), 7.83-7.71 (m, 1H), 7.68 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.60-7.52 (m, 2H), 7.06 (d, J = 2.3 Hz, 1H), 6.16 (s, 1H), 4.18 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 3.93-3.83 (m, 1H), 3.68 (d, J = 13.9 Hz, 1H), 1.25-1.09 (m, 4H), 0.89 (s, 9H). 
               
               
                 1032 
                 1H NMR (400 MHz, Methanol-d4) δ 9.30 (s, 1H), 8.39 (s, 1H), 8.00 (s, 1H), 7.97 (s, 
               
               
                   
                 1H), 7.85 (s, 1H), 7.74-7.59 (m, 5H), 7.06 (d, J = 2.3 Hz, 1H), 6.18 (s, 1H), 4.07 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 3.94-3.84 (m, 1H), 3.69 (d, J = 13.9 Hz, 1H), 1.25-1.11 (m, 4H), 
               
               
                   
                 0.92 (s, 9H). 
               
               
                 1033 
                 1H NMR (400 MHz, Methanol-d4) δ 8.45 (s, 1H), 8.21 (d, J = 2.5 Hz, 1H), 7.89 (s, 
               
               
                   
                 1H), 7.83 (s, 1H), 7.71 (d, J = 1.8 Hz, 1H), 7.67 (d, J = 2.3 Hz, 2H), 7.48 (t, J = 7.8 Hz, 
               
               
                   
                 1H), 7.43 (d, J = 7.7 Hz, 1H), 7.04 (d, J = 2.2 Hz, 1H), 6.52 (dd, J = 2.6, 1.8 Hz, 1H), 
               
               
                   
                 6.12 (s, 1H), 4.16 (d, J = 13.9 Hz, 1H), 3.92-3.83 (m, 1H), 3.65 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 1.23-1.09 (m, 4H), 0.88 (s, 9H). 
               
               
                 1034 
                 1H NMR (400 MHz, DMSO-d6) δ 8.34 (d, J = 8.2 Hz, 1H), 8.01-7.96 (m, 1H), 
               
               
                   
                 7.82 (dd, J = 10.5, 2.5 Hz, 1H), 7.53-7.45 (m, 2H), 7.34 (dd, J = 32.2, 2.5 Hz, 1H), 
               
               
                   
                 7.25-7.17 (m, 1H), 7.16-7.07 (m, 1H), 6.70 (dd, J = 59.0, 10.0 Hz, 1H), 4.58-4.43 (m, 
               
               
                   
                 1H), 4.02-3.88 (m, 1H), 2.20 (dd, J = 9.8, 6.4 Hz, 1H), 1.97-1.40 (m, 4H), 
               
               
                   
                 1.22-1.01 (m, 4H), 1.00-0.67 (m, 6H). 
               
               
                 1035 
                 1H NMR (400 MHz, Methanol-d4) δ 8.40 (s, 1H), 7.91 (s, 1H), 7.75 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.50-7.46 (m, 1H), 7.44 (m, 1H), 7.37-7.27 (m, 2H), 7.01 (d, J = 2.5 Hz, 1H), 
               
               
                   
                 6.29 (s, 1H), 3.95 (d, J = 13.2 Hz, 1H), 3.88 (d, J = 13.1 Hz, 1H), 3.53 (s, 2H), 1.66 (s, 
               
               
                   
                 3H), 1.36-1.29 (m, 2H), 1.09-1.03 (m, 2H), 0.99 (s, 3H), 0.98 (s, 3H) 
               
               
                 1036 
                 1H NMR (400 MHz, DMSO-d6) δ 8.32 (s, 1H), 8.09 (s, 1H), 7.81 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 7.50-7.38 (m, 4H), 7.31 (dd, J = 5.9, 3.5 Hz, 3H), 6.40 (d, J = 7.5 Hz, 1H), 4.74 (s, 
               
               
                   
                 1H), 4.62 (s, 1H), 3.76 (dd, J = 13.8, 7.5 Hz, 1H), 3.52 (dd, J = 13.7, 5.7 Hz, 1H), 
               
               
                   
                 1.45-1.29 (m, 4H), 0.86 (s, 9H). 
               
               
                 1037 
                 1H NMR (400 MHz, DMSO-d6) δ 9.22 (s, 1H), 8.94 (s, 2H), 8.30 (s, 1H), 8.07 (d, J = 0.5 Hz, 
               
               
                   
                 1H), 7.56-7.51 (m, 1H), 7.48 (d, J = 2.3 Hz, 1H), 7.47-7.43 (m, 1H), 
               
               
                   
                 7.35-7.28 (m, 2H), 7.15 (d, J = 2.4 Hz, 1H), 6.42 (s, 1H), 3.83 (dd, J = 13.7, 7.3 Hz, 1H), 
               
               
                   
                 3.59 (dd, J = 13.7, 5.7 Hz, 1H), 1.62 (d, J = 0.6 Hz, 3H), 1.29-1.22 (m, 2H), 
               
               
                   
                 1.09-0.99 (m, 2H), 0.90 (s, 9H). 
               
               
                 1038 
                 1H NMR (400 MHz, Methanol-d4) δ 8.51 (s, 1H), 8.12 (s, 1H), 7.80 (dd, J = 2.4, 0.6 Hz, 
               
               
                   
                 1H), 7.74 (dd, J = 1.9, 0.6 Hz, 1H), 7.65 (d, J = 2.3 Hz, 1H), 7.44 (dd, J = 6.1, 3.1 Hz, 
               
               
                   
                 1H), 7.39-7.30 (m, 2H), 7.05 (d, J = 2.3 Hz, 1H), 6.54 (t, J = 2.2 Hz, 1H), 6.33 (s, 
               
               
                   
                 1H), 3.99 (d, J = 14.0 Hz, 1H), 3.93 (d, J = 13.9 Hz, 1H), 2.11 (s, 3H), 1.80-1.66 (m, 
               
               
                   
                 4H), 0.96 (s, 9H). 
               
               
                 1039 
                 1H NMR (400 MHz, Methanol-d4) δ 8.50 (s, 1H), 8.11 (s, 1H), 7.97 (s, 2H), 7.67 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.46 (dd, J = 11.1, 8.1 Hz, 2H), 7.37 (t, J = 7.8 Hz, 1H), 6.98 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 6.36 (s, 1H), 4.02 (d, J = 13.9 Hz, 1H), 3.83 (d, J = 13.9 Hz, 1H), 2.17 (s, 
               
               
                   
                 3H), 1.80-1.66 (m, 4H), 0.92 (s, 9H). 
               
               
                 1040 
                 1H NMR (400 MHz, Methanol-d4) δ 8.69 (s, 1H), 8.52 (s, 1H), 8.22 (s, 1H), 8.15 (s, 
               
               
                   
                 1H), 7.66 (d, J = 2.3 Hz, 1H), 7.50 (q, J = 4.4 Hz, 1H), 7.39 (dd, J = 4.6, 0.7 Hz, 2H), 
               
               
                   
                 7.05 (d, J = 2.3 Hz, 1H), 6.36 (s, 1H), 4.01 (d, J = 14.0 Hz, 1H), 3.91 (d, J = 14.0 Hz, 
               
               
                   
                 1H), 2.15 (s, 3H), 1.83-1.60 (m, 4H), 0.95 (s, 9H). 
               
               
                 1041 
                 1H NMR (400 MHz, Methanol-d4) δ 8.99 (s, 1H), 8.29 (s, 1H), 8.15 (s, 1H), 7.66 (s, 
               
               
                   
                 2H), 7.48 (dd, J = 6.8, 2.5 Hz, 1H), 7.46 (d, J = 2.3 Hz, 1H), 7.42-7.32 (m, 2H), 
               
               
                   
                 6.97 (d, J = 2.4 Hz, 1H), 6.29 (s, 1H), 3.85-3.71 (m, 2H), 2.14 (s, 3H), 1.82-1.42 (m, 
               
               
                   
                 4H), 0.86 (s, 9H). 
               
               
                 1042 
                 1H NMR (400 MHz, Methanol-d4) δ 9.20 (t, J = 1.5 Hz, 1H), 8.30 (s, 1H), 8.25 (s, 
               
               
                   
                 1H), 7.80 (d, J = 1.4 Hz, 2H), 7.69 (d, J = 2.5 Hz, 1H), 7.61 (dd, J = 6.9, 2.5 Hz, 1H), 
               
               
                   
                 7.52-7.42 (m, 2H), 7.31 (d, J = 2.5 Hz, 1H), 6.39 (s, 1H), 3.76 (q, 2H), 2.25 (s, 3H), 
               
               
                   
                 1.82-1.59 (m, 4H), 0.94 (s, 9H). 
               
               
                 1043 
                 1H NMR (400 MHz, Methanol-d4) δ 8.69 (s, 1H), 8.37 (s, 1H), 8.22 (s, 1H), 8.14 (s, 
               
               
                   
                 1H), 7.79 (d, J = 2.5 Hz, 1H), 7.56-7.48 (m, 1H), 7.44-7.36 (m, 2H), 7.22 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.36 (s, 1H), 3.85 (d, J = 13.9 Hz, 1H), 3.78 (d, J = 13.9 Hz, 1H), 2.16 (s, 
               
               
                   
                 3H), 1.81-1.64 (m, 4H), 0.92 (s, 9H). 
               
               
                 1044 
                 1H NMR (400 MHz, Methanol-d4) δ 8.37 (s, 1H), 8.10 (s, 1H), 7.96 (s, 2H), 7.81 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.55-7.47 (m, 1H), 7.47-7.41 (m, 1H), 7.37 (t, J = 7.8 Hz, 1H), 
               
               
                   
                 7.16 (d, J = 2.5 Hz, 1H), 6.36 (s, 1H), 3.84 (d, J = 13.8 Hz, 1H), 3.72 (d, J = 13.8 Hz, 1H), 
               
               
                   
                 2.18 (s, 3H), 1.79-1.65 (m, 4H), 0.89 (s, 9H). 
               
               
                 1045 
                 1H NMR (400 MHz, Methanol-d4) δ 8.37 (s, 1H), 8.12 (s, 1H), 7.84-7.76 (m, 2H), 
               
               
                   
                 7.74 (dd, J = 1.9, 0.7 Hz, 1H), 7.45 (dd, J = 6.8, 2.6 Hz, 1H), 7.39-7.28 (m, 2H), 
               
               
                   
                 7.23 (d, J = 2.6 Hz, 1H), 6.57-6.51 (m, 1H), 6.33 (s, 1H), 3.84 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 3.79 (d, J = 13.9 Hz, 1H), 2.12 (s, 3H), 1.79-1.63 (m, 4H), 0.92 (s, 9H). 
               
               
                 1046 
                 1H NMR (400 MHz, DMSO-d6) δ 8.32 (s, 1H), 7.64 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.42-7.30 (m, 2H), 7.24-7.17 (m, 2H), 7.07 (s, 1H), 3.82 (dd, J = 13.7, 7.2 Hz, 1H), 3.58 (dd, J = 13.8, 
               
               
                   
                 6.0 Hz, 1H), 1.62 (d, J = 0.6 Hz, 3H), 1.27-1.18 (m, 2H), 1.07-0.98 (m, 2H), 
               
               
                   
                 0.94 (s, 9H). 
               
               
                 1047 
                 1H NMR (400 MHz, DMSO-d6) δ 8.34 (s, 1H), 8.15 (s, 1H), 7.65 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.43-7.31 (m, 2H), 7.25-7.17 (m, 2H), 7.11 (s, 1H), 3.83 (dd, J = 13.8, 7.3 Hz, 1H), 
               
               
                   
                 3.59 (dd, J = 13.8, 6.1 Hz, 1H), 1.62 (d, J = 0.6 Hz, 3H), 1.28-1.19 (m, 2H), 
               
               
                   
                 1.07-1.00 (m, 2H), 0.94 (s, 9H). 
               
               
                 1048 
                 1H NMR (400 MHz, DMSO-d6) δ 8.33 (s, 1H), 7.87 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 7.55-7.49 (m, 2H), 7.43-7.32 (m, 2H), 7.24-7.18 (m, 1H), 7.17 (s, 1H), 3.83-3.76 (m, 1H), 
               
               
                   
                 3.59 (dd, J = 13.9, 6.2 Hz, 1H), 1.61 (s, 3H), 1.23 (t, J = 3.7 Hz, 2H), 1.07-0.98 (m, 
               
               
                   
                 2H), 0.93 (s, 9H). 
               
               
                 1049 
                 1H NMR (400 MHz, Methanol-d4) δ 8.68 (s, 1H), 8.51 (s, 1H), 8.22 (s, 1H), 8.00 (s, 
               
               
                   
                 1H), 7.65 (d, J = 2.3 Hz, 1H), 7.51 (q, J = 4.1 Hz, 1H), 7.44-7.36 (m, 2H), 7.04 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 6.34 (s, 1H), 5.94 (t, J = 54.7 Hz, 1H), 4.01 (d, J = 14.0 Hz, 1H), 
               
               
                   
                 3.90 (d, J = 14.0 Hz, 1H), 2.15 (s, 3H), 1.54 (s, 4H), 0.96 (s, 9H). 
               
               
                 1050 
                 1H NMR (400 MHz, Methanol-d4) δ 8.48 (s, 1H), 8.09-8.01 (m, 2H), 7.83-7.76 (m, 
               
               
                   
                 1H), 7.65 (d, J = 2.2 Hz, 1H), 7.49-7.42 (m, 1H), 7.35 (d, J = 0.9 Hz, 1H), 7.32 (t, J = 7.8 Hz, 
               
               
                   
                 1H), 6.91 (d, J = 2.3 Hz, 1H), 6.37 (s, 1H), 4.03 (d, J = 13.9 Hz, 1H), 3.78 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 2.60 (s, 3H), 1.79-1.65 (m, 4H), 0.87 (s, 9H). 
               
               
                 1051 
                 1H NMR (400 MHz, Methanol-d4) δ 8.49 (s, 1H), 8.04 (d, J = 0.9 Hz, 1H), 7.91 (s, 
               
               
                   
                 1H), 7.83-7.76 (m, 1H), 7.66 (d, J = 2.2 Hz, 1H), 7.46 (d, J = 7.8 Hz, 1H), 7.35 (d, J = 0.9 Hz, 
               
               
                   
                 1H), 7.32 (t, J = 7.8 Hz, 1H), 6.92 (d, J = 2.3 Hz, 1H), 6.36 (s, 1H), 5.94 (t, J = 54.8 Hz, 
               
               
                   
                 1H), 4.04 (d, J = 13.8 Hz, 1H), 3.78 (d, J = 13.9 Hz, 1H), 2.59 (s, 3H), 
               
               
                   
                 1.53 (s, 4H), 0.88 (s, 9H). 
               
               
                 1052 
                 1H NMR (400 MHz, DMSO-d6) δ 8.27 (s, 1H), 7.98 (s, 1H), 7.75 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.56-7.39 (m, 4H), 7.35-7.25 (m, 3H), 7.23-7.12 (m, 2H), 7.03 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 6.37 (d, J = 7.3 Hz, 1H), 5.64 (s, 2H), 3.77 (dd, J = 13.7, 7.5 Hz, 1H), 3.48 (dd, J = 13.6, 
               
               
                   
                 5.6 Hz, 1H), 0.84 (s, 9H).; 1H NMR (400 MHz, DMSO-d6) δ 8.31 (s, 1H), 
               
               
                   
                 7.99 (s, 1H), 7.79 (d, J = 2.4 Hz, 1H), 7.57-7.38 (m, 4H), 7.37-7.26 (m, 4H), 
               
               
                   
                 7.22-7.12 (m, 2H), 6.41 (d, J = 7.0 Hz, 1H), 5.64 (s, 2H), 3.77 (dd, J = 13.7, 7.5 Hz, 1H), 
               
               
                   
                 3.49 (dd, J = 13.7, 5.6 Hz, 1H), 0.84 (s, 9H). 
               
               
                 1053 
                 1H NMR (400 MHz, DMSO-d6) δ 8.27 (s, 1H), 7.98 (s, 1H), 7.75 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 7.56-7.39 (m, 4H), 7.35-7.25 (m, 3H), 7.23-7.12 (m, 2H), 7.03 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 6.37 (d, J = 7.3 Hz, 1H), 5.64 (s, 2H), 3.77 (dd, J = 13.7, 7.5 Hz, 1H), 3.48 (dd, J = 13.6, 
               
               
                   
                 5.6 Hz, 1H), 0.84 (s, 9H).; 1H NMR (400 MHz, DMSO-d6) δ 8.31 (s, 1H), 
               
               
                   
                 7.99 (s, 1H), 7.79 (d, J = 2.4 Hz, 1H), 7.57-7.38 (m, 4H), 7.37-7.26 (m, 4H), 
               
               
                   
                 7.22-7.12 (m, 2H), 6.41 (d, J = 7.0 Hz, 1H), 5.64 (s, 2H), 3.77 (dd, J = 13.7, 7.5 Hz, 1H), 
               
               
                   
                 3.49 (dd, J = 13.7, 5.6 Hz, 1H), 0.84 (s, 9H). 
               
               
                 1054 
                 1H NMR (400 MHz, Methanol-d4) δ 8.69 (s, 1H), 8.35 (s, 1H), 8.22 (s, 1H), 8.00 (s, 
               
               
                   
                 1H), 7.78 (d, J = 2.5 Hz, 1H), 7.57-7.50 (m, 1H), 7.44-7.34 (m, 2H), 7.20 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.34 (s, 1H), 5.95 (t, J = 54.8 Hz, 1H), 3.84 (d, J = 13.8 Hz, 1H), 3.75 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 2.16 (s, 3H), 1.53 (s, 4H), 0.92 (s, 9H). 
               
               
                 1055 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 8.06 (s, 1H), 8.03 (d, J = 0.9 Hz, 
               
               
                   
                 1H), 7.82-7.76 (m, 2H), 7.47 (d, J = 7.5 Hz, 1H), 7.37-7.27 (m, 2H), 7.07 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.37 (s, 1H), 3.85 (d, J = 13.7 Hz, 1H), 3.64 (d, J = 13.7 Hz, 1H), 2.61 (s, 
               
               
                   
                 3H), 1.79-1.64 (m, 4H), 0.83 (s, 9H). 
               
               
                 1056 
                 1H NMR (400 MHz, Methanol-d4) δ 8.33 (s, 1H), 8.03 (d, J = 0.9 Hz, 1H), 7.91 (s, 
               
               
                   
                 1H), 7.84-7.70 (m, 2H), 7.48 (d, J = 7.8 Hz, 1H), 7.34 (d, J = 0.9 Hz, 1H), 7.32 (t, J = 7.8 Hz, 
               
               
                   
                 1H), 7.06 (d, J = 2.5 Hz, 1H), 6.35 (s, 1H), 5.95 (t, J = 54.8 Hz, 1H), 3.85 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 3.62 (d, J = 13.7 Hz, 1H), 2.61 (s, 3H), 1.52 (s, 4H), 0.83 (s, 9H). 
               
               
                 1057 
                 1H NMR (400 MHz, Methanol-d4) δ 9.45 (s, 1H), 8.47 (s, 1H), 8.19 (s, 1H), 7.65 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.61-7.56 (m, 1H), 7.48-7.41 (m, 2H), 6.99 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 6.38 (s, 1H), 4.00 (d, J = 13.9 Hz, 1H), 3.83 (d, J = 13.9 Hz, 1H), 2.12 (s, 3H), 
               
               
                   
                 1.81-1.66 (m, 4H), 0.94 (s, 9H). 
               
               
                 1058 
                 1H NMR (400 MHz, Methanol-d4) δ 8.45 (s, 1H), 7.84 (s, 1H), 7.65 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.47 (d, J = 7.2 Hz, 2H), 7.41-7.32 (m, 2H), 7.35-7.26 (m, 1H), 7.07 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 6.08 (s, 1H), 5.93 (t, J = 54.7 Hz, 1H), 4.15 (d, J = 13.9 Hz, 1H), 3.74 (d, J = 14.0 Hz, 
               
               
                   
                 1H), 1.51 (s, 4H), 0.97 (s, 9H). 
               
               
                 1059 
                 1H NMR (400 MHz, Methanol-d4) δ 8.47 (s, 1H), 7.98 (s, 1H), 7.66 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.51-7.44 (m, 2H), 7.42-7.33 (m, 2H), 7.36-7.27 (m, 1H), 7.09 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 6.10 (s, 1H), 4.16 (d, J = 13.9 Hz, 1H), 3.76 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 1.78-1.59 (m, 4H), 0.97 (s, 9H). 
               
               
                 1060 
                 1H NMR (400 MHz, Methanol-d4) δ 8.46 (s, 1H), 7.82 (s, 1H), 7.61 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.28-7.19 (m, 3H), 7.16 (t, J = 7.0 Hz, 1H), 6.91 (d, J = 2.3 Hz, 1H), 6.21 (s, 
               
               
                   
                 1H), 5.92 (t, J = 54.7 Hz, 1H), 3.99 (d, J = 13.8 Hz, 1H), 3.84 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 2.38 (s, 3H), 1.51 (s, 4H), 0.94 (s, 9H). 
               
               
                 1061 
                 1H NMR (400 MHz, Methanol-d4) δ 8.47 (s, 1H), 7.98 (s, 1H), 7.62 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.28-7.19 (m, 3H), 7.19-7.13 (m, 1H), 6.93 (d, J = 2.3 Hz, 1H), 6.23 (s, 1H), 
               
               
                   
                 4.00 (d, J = 13.8 Hz, 1H), 3.86 (d, J = 13.9 Hz, 1H), 2.38 (s, 3H), 1.78-1.59 (m, 4H), 
               
               
                   
                 0.94 (s, 9H). 
               
               
                 1062 
                 1H NMR (400 MHz, Methanol-d4) δ 9.45 (s, 1H), 8.50 (s, 1H), 8.04 (s, 1H), 7.66 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.59 (dd, J = 5.9, 3.3 Hz, 1H), 7.45 (d, J = 2.7 Hz, 1H), 7.43 (s, 1H), 
               
               
                   
                 7.00 (d, J = 2.4 Hz, 1H), 6.36 (s, 1H), 5.94 (t, J = 54.6 Hz, 1H), 4.03 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 3.84 (d, J = 14.0 Hz, 1H), 2.11 (s, 3H), 1.54 (s, 4H), 0.95 (s, 9H). 
               
               
                 1063 
                 1H NMR (400 MHz, Methanol-d4) δ 8.49 (s, 1H), 8.19 (d, J = 1.1 Hz, 1H), 8.17 (s, 
               
               
                   
                 1H), 7.94 (d, J = 1.1 Hz, 1H), 7.66 (d, J = 2.3 Hz, 1H), 7.54 (dd, J = 7.0, 2.1 Hz, 1H), 
               
               
                   
                 7.46-7.35 (m, 2H), 7.01 (d, J = 2.2 Hz, 1H), 6.37 (s, 1H), 4.00 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 3.86 (d, J = 13.9 Hz, 1H), 2.10 (s, 3H), 1.81-1.66 (m, 4H), 0.94 (s, 9H). 
               
               
                 1064 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 7.86 (s, 1H), 7.80 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.52-7.45 (m, 2H), 7.36 (dd, J = 8.5, 6.6 Hz, 2H), 7.33-7.27 (m, 1H), 7.26 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.08 (s, 1H), 5.93 (t, J = 54.7 Hz, 1H), 4.03 (d, J = 13.8 Hz, 1H), 
               
               
                   
                 3.63 (d, J = 13.9 Hz, 1H), 1.51 (s, 4H), 0.94 (s, 9H). 
               
               
                 1065 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 8.00 (s, 1H), 7.80 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.52-7.45 (m, 2H), 7.37 (dd, J = 8.2, 6.5 Hz, 2H), 7.30 (t, J = 7.3 Hz, 1H), 
               
               
                   
                 7.26 (d, J = 2.5 Hz, 1H), 6.10 (s, 1H), 4.01 (d, J = 13.9 Hz, 1H), 3.64 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 1.78-1.62 (m, 4H), 0.94 (s, 9H). 
               
               
                 1066 
                 1H NMR (400 MHz, Methanol-d4) δ 8.37 (s, 1H), 7.85 (s, 1H), 7.77 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.29-7.19 (m, 3H), 7.19-7.13 (m, 1H), 7.10 (d, J = 2.5 Hz, 1H), 6.22 (s, 1H), 
               
               
                   
                 5.93 (t, J = 54.7 Hz, 1H), 3.87 (d, J = 13.8 Hz, 1H), 3.74 (d, J = 13.8 Hz, 1H), 2.38 (s, 
               
               
                   
                 3H), 1.51 (s, 4H), 0.90 (s, 9H). 
               
               
                 1067 
                 1H NMR (400 MHz, Methanol-d4) δ 8.36 (s, 1H), 8.00 (s, 1H), 7.77 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.28-7.19 (m, 3H), 7.19-7.13 (m, 1H), 7.11 (d, J = 2.5 Hz, 1H), 6.23 (s, 1H), 
               
               
                   
                 3.86 (d, J = 13.8 Hz, 1H), 3.74 (d, J = 13.8 Hz, 1H), 2.39 (s, 3H), 1.78-1.62 (m, 4H), 
               
               
                   
                 0.90 (s, 9H). 
               
               
                 1068 
                 1H NMR (400 MHz, Methanol-d4) δ 8.38 (s, 1H), 8.19 (d, J = 1.1 Hz, 1H), 8.17 (s, 
               
               
                   
                 1H), 7.94 (d, J = 1.1 Hz, 1H), 7.81 (d, J = 2.5 Hz, 1H), 7.54 (dd, J = 7.3, 2.0 Hz, 1H), 
               
               
                   
                 7.46-7.35 (m, 2H), 7.20 (d, J = 2.5 Hz, 1H), 6.37 (s, 1H), 3.86 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 3.75 (d, J = 13.8 Hz, 1H), 2.11 (s, 3H), 1.80-1.66 (m, 4H), 0.91 (s, 9H). 
               
               
                 1069 
                 1H NMR (400 MHz, Methanol-d4) δ 9.16 (s, 1H), 8.47 (s, 1H), 8.10 (s, 1H), 7.78 (s, 
               
               
                   
                 2H), 7.59 (dd, J = 5.2, 2.1 Hz, 2H), 7.52-7.41 (m, 2H), 7.13 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 6.38 (s, 1H), 5.94 (t, J = 54.7 Hz, 1H), 3.97 (d, J = 13.9 Hz, 1H), 3.91 (d, J = 14.0 Hz, 1H), 
               
               
                   
                 2.23 (s, 3H), 1.55 (s, 4H), 0.98 (s, 9H). 
               
               
                 1070 
                 1H NMR (400 MHz, Methanol-d4) δ 8.73 (s, 2H), 8.52 (s, 1H), 8.04 (s, 1H), 7.64 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.55-7.48 (m, 1H), 7.46-7.36 (m, 2H), 7.08 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 6.35 (s, 1H), 5.94 (t, J = 54.6 Hz, 1H), 4.00 (d, J = 13.9 Hz, 1H), 3.95 (d, J = 14.0 Hz, 1H), 
               
               
                   
                 2.16 (s, 3H), 1.54 (s, 4H), 0.97 (s, 9H). 
               
               
                 1071 
                 1H NMR (400 MHz, Methanol-d4) δ 8.72 (s, 2H), 8.51 (s, 1H), 8.19 (s, 1H), 7.64 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.51 (d, J = 6.5 Hz, 1H), 7.44-7.38 (m, 2H), 7.08 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 6.36 (s, 1H), 3.97 (d, J = 1.3 Hz, 2H), 2.16 (s, 3H), 1.88-1.55 (m, 4H), 0.97 (s, 9H). 
               
               
                 1072 
                 1H NMR (400 MHz, Methanol-d4) δ 8.79 (s, 2H), 8.35 (s, 1H), 8.19 (s, 1H), 7.76 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.54 (dd, J = 7.2, 1.9 Hz, 1H), 7.47-7.36 (m, 2H), 7.26 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.37 (s, 1H), 3.81 (d, J = 1.3 Hz, 2H), 2.18 (s, 3H), 1.89-1.55 (m, 4H), 0.93 (s, 
               
               
                   
                 9H). 
               
               
                 1073 
                 1H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 2H), 8.33 (s, 1H), 8.05 (s, 1H), 7.75 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.55 (d, J = 7.2 Hz, 1H), 7.46-7.35 (m, 2H), 7.24 (d, J = 2.5 Hz, 1H), 
               
               
                   
                 6.35 (s, 1H), 5.95 (t, J = 54.7 Hz, 1H), 3.83 (d, J = 13.9 Hz, 1H), 3.77 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 2.17 (s, 3H), 1.54 (s, 4H), 0.93 (s, 9H). 
               
               
                 1074 
                 1H NMR (400 MHz, Methanol-d4) δ 8.52 (s, 1H), 8.27 (s, 1H), 7.82 (dd, J = 7.7, 1.6 Hz, 
               
               
                   
                 1H), 7.77 (dd, J = 8.0, 1.6 Hz, 1H), 7.66 (d, J = 2.3 Hz, 1H), 7.49 (t, J = 7.9 Hz, 
               
               
                   
                 1H), 6.92 (d, J = 2.4 Hz, 1H), 4.14 (d, J = 13.9 Hz, 1H), 3.73 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 1.85-1.62 (m, 4H), 0.96 (s, 9H). 
               
               
                 1075 
                 1H NMR (400 MHz, Methanol-d4) δ 8.51 (s, 1H), 8.11 (s, 1H), 7.82 (dd, J = 7.7, 1.6 Hz, 
               
               
                   
                 1H), 7.77 (dd, J = 8.0, 1.6 Hz, 1H), 7.65 (d, J = 2.3 Hz, 1H), 7.49 (t, J = 7.9 Hz, 
               
               
                   
                 1H), 6.92 (d, J = 2.3 Hz, 1H), 5.95 (t, J = 54.7 Hz, 1H), 4.14 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 3.73 (d, J = 13.9 Hz, 1H), 1.54 (s, 4H), 0.96 (s, 9H). 
               
               
                 1076 
                 1H NMR (400 MHz, Methanol-d4) δ 8.51 (s, 1H), 7.90 (s, 1H), 7.63 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.23 (dd, J = 8.6, 5.8 Hz, 1H), 7.02 (dd, J = 9.6, 2.6 Hz, 1H), 6.95-6.84 (m, 2H), 
               
               
                   
                 6.19 (s, 1H), 5.92 (t, J = 54.6 Hz, 1H), 4.04 (d, J = 13.9 Hz, 1H), 3.86 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 2.37 (s, 3H), 1.52 (s, 4H), 0.94 (s, 9H). 
               
               
                 1077 
                 1H NMR (400 MHz, Methanol-d4) δ 9.22 (t, J = 1.4 Hz, 1H), 8.31 (s, 1H), 8.12 (s, 
               
               
                   
                 1H), 7.81 (d, J = 1.5 Hz, 2H), 7.70 (d, J = 2.5 Hz, 1H), 7.61 (dd, J = 7.0, 2.3 Hz, 1H), 
               
               
                   
                 7.53-7.42 (m, 2H), 7.30 (d, J = 2.5 Hz, 1H), 6.38 (s, 1H), 5.94 (t, J = 54.6 Hz, 1H), 
               
               
                   
                 3.86-3.73 (m, 2H), 2.24 (s, 3H), 1.57-1.50 (m, 4H), 0.94 (s, 9H). 
               
               
                 1078 
                 1H NMR (400 MHz, DMSO-d6) δ 8.30 (s, 1H), 8.00 (s, 1H), 7.79 (d, J = 2.4 Hz, 1H), 
               
               
                   
                 7.57-7.45 (m, 4H), 7.39 (d, J = 2.5 Hz, 1H), 7.23-7.08 (m, 4H), 5.66-5.61 (m, 
               
               
                   
                 2H), 4.47 (s, 1H), 3.94 (dd, J = 14.0, 8.0 Hz, 1H), 3.41 (dd, J = 13.9, 5.5 Hz, 1H), 
               
               
                   
                 0.86 (s, 9H). 
               
               
                 1079 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 8.26 (s, 1H), 7.85-7.76 (m, 3H), 
               
               
                   
                 7.49 (t, J = 7.8 Hz, 1H), 7.05 (d, J = 2.5 Hz, 1H), 3.95 (d, J = 13.7 Hz, 1H), 3.57 (d, J = 13.7 Hz, 
               
               
                   
                 1H), 1.81-1.66 (m, 4H), 0.92 (s, 9H). 
               
               
                 1080 
                 1H NMR (400 MHz, Methanol-d4) δ 8.34 (s, 1H), 8.11 (s, 1H), 7.85-7.75 (m, 3H), 
               
               
                   
                 7.48 (t, J = 7.8 Hz, 1H), 7.03 (d, J = 2.5 Hz, 1H), 5.96 (t, J = 54.7 Hz, 1H), 3.94 (d, J = 13.7 Hz, 
               
               
                   
                 1H), 3.56 (d, J = 13.6 Hz, 1H), 1.54 (s, 4H), 0.92 (s, 9H). 
               
               
                 1081 
                 1H NMR (400 MHz, Methanol-d4) δ 9.45 (s, 1H), 8.30 (s, 1H), 8.18 (s, 1H), 7.76 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.61 (dd, J = 7.1, 2.2 Hz, 1H), 7.49-7.36 (m, 2H), 7.16 (d, J = 2.6 Hz, 
               
               
                   
                 1H), 6.38 (s, 1H), 3.80 (d, J = 13.8 Hz, 1H), 3.68 (d, J = 13.8 Hz, 1H), 2.13 (s, 3H), 
               
               
                   
                 1.80-1.65 (m, 4H), 0.90 (s, 9H). 
               
               
                 1082 
                 1H NMR (400 MHz, Methanol-d4) δ 9.45 (s, 1H), 8.33 (s, 1H), 8.04 (s, 1H), 7.78 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.61 (d, J = 7.0 Hz, 1H), 7.49-7.39 (m, 2H), 7.17 (d, J = 2.5 Hz, 1H), 
               
               
                   
                 6.37 (s, 1H), 5.95 (t, J = 54.8 Hz, 1H), 3.84 (d, J = 13.8 Hz, 1H), 3.69 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 2.13 (s, 3H), 1.54 (s, 4H), 0.91 (s, 9H). 
               
               
                 1083 
                 1H NMR (400 MHz, Methanol-d4) δ 8.33 (s, 1H), 7.90 (s, 1H), 7.75 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.26 (dd, J = 8.7, 5.8 Hz, 1H), 7.06 (d, J = 2.5 Hz, 1H), 7.01 (dd, J = 9.8, 2.6 Hz, 
               
               
                   
                 1H), 6.93-6.85 (m, 1H), 6.18 (s, 1H), 5.94 (t, J = 54.7 Hz, 1H), 3.84 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 3.70 (d, J = 13.8 Hz, 1H), 2.39 (s, 3H), 1.52 (s, 4H), 0.90 (s, 9H). 
               
               
                 1084 
                 1H NMR (400 MHz, Methanol-d4) δ 8.49 (s, 1H), 7.86 (s, 1H), 7.73 (d, J = 8.3 Hz, 
               
               
                   
                 2H), 7.69-7.61 (m, 3H), 6.99 (d, J = 2.2 Hz, 1H), 6.13 (s, 1H), 4.53 (s, 8H), 4.20 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 3.88 (ddd, J = 11.4, 7.3, 4.1 Hz, 1H), 3.69 (d, J = 14.0 Hz, 1H), 
               
               
                   
                 1.24-1.07 (m, 4H), 0.94 (s, 9H). 
               
               
                 1085 
                 1H NMR (400 MHz, Methanol-d4) δ 8.85 (br s, 2H), 8.49 (s, 1H), 8.04 (s, 1H), 
               
               
                   
                 7.94 (br s, 2H), 7.63 (d, J = 1.9 Hz, 1H), 7.46 (d, J = 8.0 Hz, 1H), 7.43-7.31 (m, 2H), 
               
               
                   
                 7.05 (s, 1H), 6.36 (s, 1H), 5.94 (t, J = 54.6 Hz, 1H), 3.95 (d, J = 4.7 Hz, 2H), 2.35 (s, 3H), 
               
               
                   
                 1.54 (s, 4H), 0.95 (s, 9H). 
               
               
                 1086 
                 1H NMR (400 MHz, Methanol-d4) δ 8.49 (s, 1H), 7.88 (s, 1H), 7.71 (s, 1H), 7.64 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.55 (s, 1H), 7.30 (dd, J = 6.9, 2.1 Hz, 1H), 7.24-7.13 (m, 2H), 6.96 (s, 
               
               
                   
                 1H), 6.30 (s, 1H), 5.93 (t, J = 54.7 Hz, 1H), 4.01 (d, J = 13.9 Hz, 1H), 3.94 (s, 3H), 
               
               
                   
                 3.84 (d, J = 13.9 Hz, 1H), 2.38 (s, 3H), 1.53 (s, 4H), 0.91 (s, 9H). 
               
               
                 1087 
                 1H NMR (400 MHz, Chloroform-d) δ 8.24 (s, 1H), 7.91-7.82 (m, 2H), 7.78 (s, 1H), 
               
               
                   
                 7.41 (s, 1H), 7.22-7.15 (m, 2H), 6.52-6.45 (m, 1H), 4.38 (q, 2H), 3.99-3.90 (m, 1H), 
               
               
                   
                 3.73-3.63 (m, 1H), 1.70-1.61 (m, 4H), 1.38 (t, 3H), 0.94 (s, 9H). 
               
               
                 1088 
                 1H NMR (400 MHz, Methanol-d4) δ 8.43 (s, 1H), 8.10 (s, 1H), 8.04 (dd, 1H), 
               
               
                   
                 7.75-7.68 (m, 1H), 7.65 (d, 1H), 7.27-7.16 (m, 2H), 7.00 (d, 1H), 6.15 (s, 1H), 4.14 (d, 
               
               
                   
                 1H), 3.87 (s, 3H), 3.70-3.65 (m, 1H), 1.78-1.59 (m, 4H), 0.93 (s, 9H). 
               
               
                 1089 
                 1H NMR (400 MHz, Methanol-d4) δ 8.51 (d, J = 1.3 Hz, 1H), 7.98 (s, 1H), 
               
               
                   
                 7.73-7.64 (m, 2H), 7.58 (d, J = 7.9 Hz, 1H), 7.34 (t, J = 7.8 Hz, 1H), 6.78 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 6.26 (s, 1H), 5.94 (t, J = 54.6 Hz, 1H), 4.42 (d, J = 14.9 Hz, 1H), 4.09 (d, J = 14.9 Hz, 
               
               
                   
                 1H), 2.57 (s, 3H), 1.53 (s, 4H), 1.13 (d, J = 6.4 Hz, 6H). 
               
               
                 1090 
                 1H NMR (400 MHz, Methanol-d4) δ 8.47 (s, 1H), 8.04 (s, 1H), 7.63 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.25-6.98 (m, 3H), 6.89 (d, J = 2.3 Hz, 1H), 6.24 (s, 1H), 4.04 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 3.78 (d, J = 13.9 Hz, 1H), 2.26 (d, J = 2.0 Hz, 3H), 1.83-1.60 (m, 4H), 0.93 (s, 
               
               
                   
                 9H). 
               
               
                 1091 
                 1H NMR (400 MHz, Methanol-d4) δ 8.47 (s, 1H), 8.06 (s, 1H), 7.67 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.48 (d, J = 2.0 Hz, 1H), 7.43-7.36 (m, 2H), 7.26-7.19 (m, 1H), 7.08 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 6.14 (s, 1H), 4.13 (d, J = 14.0 Hz, 1H), 3.77 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 1.77-1.73 (m, 2H), 1.73-1.69 (m, 2H), 1.69-1.61 (m, 2H), 1.49-1.44 (m, 1H), 
               
               
                   
                 1.44-1.37 (m, 1H), 0.97 (s, 9H). 
               
               
                 1092 
                 1H NMR (400 MHz, Methanol-d4) δ 8.47 (s, 1H), 7.76 (s, 1H), 7.64 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.47 (dd, J = 8.6, 5.2 Hz, 2H), 7.09 (t, J = 8.7 Hz, 2H), 7.02 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 6.05 (s, 1H), 4.14 (d, J = 13.9 Hz, 1H), 3.76 (d, J = 13.9 Hz, 1H), 2.68 (s, 1H), 2.36 (s, 
               
               
                   
                 6H), 0.96 (s, 9H). 
               
               
                 1093 
                 1H NMR (400 MHz, Methanol-d4) δ 8.44 (s, 1H), 7.71 (s, 1H), 7.64 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.46 (d, J = 7.5 Hz, 2H), 7.36 (t, J = 7.5 Hz, 2H), 7.31 (d, J = 7.2 Hz, 1H), 7.03 (d, 
               
               
                   
                 J = 2.3 Hz, 1H), 6.05 (s, 1H), 4.11 (d, J = 13.9 Hz, 1H), 3.75 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 2.68 (s, 1H), 2.36 (s, 6H), 0.96 (s, 9H). 
               
               
                 1094 
                 1H NMR (400 MHz, Methanol-d4) δ 8.49 (s, 1H), 7.78 (s, 1H), 7.67 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.48 (s, 1H), 7.41-7.35 (m, 2H), 7.22 (td, J = 4.7, 2.0 Hz, 1H), 7.04 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 6.10 (s, 1H), 4.13 (d, J = 14.0 Hz, 1H), 3.78 (d, J = 13.9 Hz, 1H), 2.68 (s, 
               
               
                   
                 1H), 2.37 (s, 6H), 1.75-1.64 (m, 2H), 1.53-1.36 (m, 2H), 0.96 (s, 9H). 
               
               
                 1095 
                 1H NMR (400 MHz, Methanol-d4) δ 8.84 (s, 1H), 8.49 (s, 1H), 8.19 (s, 1H), 7.91 (d, J = 5.7 Hz, 
               
               
                   
                 2H), 7.63 (d, J = 2.3 Hz, 1H), 7.45 (d, J = 7.5 Hz, 1H), 7.40 (d, J = 7.6 Hz, 
               
               
                   
                 1H), 7.38-7.32 (m, 2H), 7.07 (d, J = 2.3 Hz, 1H), 6.38 (s, 1H), 3.95 (s, 2H), 2.35 (s, 
               
               
                   
                 3H), 1.84-1.57 (m, 4H), 0.95 (s, 9H). 
               
               
                 1096 
                 1H NMR (400 MHz, Methanol-d4) δ 8.70 (d, J = 19.0 Hz, 1H), 8.49 (s, 1H), 8.19 (d, J = 8.0 Hz, 
               
               
                   
                 1H), 8.15 (s, 1H), 7.94-7.78 (m, 1H), 7.64 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 7.41-7.38 (m, 1H), 7.35 (t, J = 7.6 Hz, 2H), 7.32-7.28 (m, 1H), 7.06 (d, J = 2.3 Hz, 1H), 6.37 (s, 
               
               
                   
                 1H), 4.05-3.83 (m, 2H), 2.29 (s, 3H), 1.85-1.61 (m, 4H), 0.95 (s, 9H). 
               
               
                 1097 
                 1H NMR (400 MHz, Methanol-d4) δ 8.50 (s, 1H), 8.03 (s, 1H), 7.71 (s, 1H), 7.65 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.54 (s, 1H), 7.34-7.25 (m, 1H), 7.20 (s, 1H), 7.18 (d, J = 3.6 Hz, 1H), 
               
               
                   
                 6.98 (d, J = 2.2 Hz, 1H), 6.33 (s, 1H), 4.02 (d, J = 13.9 Hz, 1H), 3.94 (s, 3H), 3.86 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 2.38 (s, 3H), 1.78-1.72 (m, 2H), 1.67 (s, 2H), 0.91 (s, 9H). 
               
               
                 1098 
                 1H NMR (400 MHz, Methanol-d4) δ 8.49 (s, 1H), 7.98 (s, 1H), 7.63 (d, J = 1.9 Hz, 
               
               
                   
                 2H), 7.54 (d, J = 8.2 Hz, 1H), 7.49 (d, J = 8.1 Hz, 1H), 6.86 (s, 1H), 6.26 (s, 1H), 
               
               
                   
                 5.93 (t, J = 54.7 Hz, 1H), 4.08 (d, J = 13.9 Hz, 1H), 3.75 (d, J = 13.9 Hz, 1H), 2.41 (s, 3H), 
               
               
                   
                 1.53 (s, 4H), 0.92 (s, 9H). 
               
               
                 1099 
                 1H NMR (400 MHz, Methanol-d4) δ 8.48 (s, 1H), 8.12 (s, 1H), 7.63 (d, J = 2.3 Hz, 
               
               
                   
                 2H), 7.55 (d, J = 8.4 Hz, 1H), 7.48 (d, J = 8.0 Hz, 1H), 6.88-6.83 (m, 1H), 6.27 (s, 
               
               
                   
                 1H), 4.07 (d, J = 13.9 Hz, 1H), 3.75 (d, J = 13.9 Hz, 1H), 2.41 (s, 3H), 1.86-1.56 (m, 
               
               
                   
                 4H), 0.92 (s, 9H). 
               
               
                 1100 
                 1H NMR (400 MHz, Methanol-d4) δ 8.48 (d, J = 1.4 Hz, 1H), 7.93 (s, 1H), 7.67 (d, J = 7.7 Hz, 
               
               
                   
                 1H), 7.64 (d, J = 2.1 Hz, 1H), 7.61 (d, J = 8.0 Hz, 1H), 7.34 (t, J = 7.8 Hz, 1H), 
               
               
                   
                 6.80 (d, J = 2.1 Hz, 1H), 6.26 (s, 1H), 4.61 (d, J = 48.4 Hz, 2H), 4.11 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 3.71 (d, J = 13.8 Hz, 1H), 2.57 (s, 3H), 1.55-1.44 (m, 2H), 1.38-1.31 (m, 2H), 
               
               
                   
                 0.91 (d, J = 1.3 Hz, 9H). 
               
               
                 1101 
                 1H NMR (400 MHz, Methanol-d4) δ 8.48 (s, 1H), 7.90 (s, 1H), 7.66 (d, J = 7.8 Hz, 
               
               
                   
                 1H), 7.63 (d, J = 2.1 Hz, 1H), 7.60 (d, J = 8.2 Hz, 1H), 7.34 (t, J = 7.8 Hz, 1H), 6.78 (d, 
               
               
                   
                 J = 2.1 Hz, 1H), 6.23 (s, 1H), 4.10 (d, J = 13.8 Hz, 1H), 3.70 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 2.56 (s, 3H), 1.66 (s, 3H), 1.36-1.27 (m, 2H), 1.10-1.02 (m, 2H), 0.90 (d, J = 1.3 Hz, 
               
               
                   
                 9H). 
               
               
                 1102 
                 1H NMR (400 MHz, Methanol-d4) δ 8.52 (s, 1H), 7.95 (s, 1H), 7.74-7.65 (m, 2H), 
               
               
                   
                 7.61 (d, J = 7.7 Hz, 1H), 7.35 (t, J = 7.8 Hz, 1H), 6.84 (d, J = 2.2 Hz, 1H), 6.30 (s, 1H), 
               
               
                   
                 5.42-5.11 (m, 1H), 5.03-4.77 (m, 4H), 4.14 (d, J = 14.0 Hz, 1H), 3.73 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 2.57 (s, 3H), 0.92 (s, 9H). 
               
               
                 1103 
                 1H NMR (400 MHz, Methanol-d4) δ 8.49 (d, J = 1.3 Hz, 1H), 7.87 (s, 1H), 7.67 (d, J = 7.7 Hz, 
               
               
                   
                 1H), 7.65 (d, J = 2.1 Hz, 1H), 7.61 (d, J = 8.0 Hz, 1H), 7.35 (t, J = 7.8 Hz, 1H), 
               
               
                   
                 6.81 (d, J = 2.2 Hz, 1H), 6.27 (s, 1H), 5.06-4.94 (m, 1H), 4.70 (d, J = 46.8 Hz, 1H), 
               
               
                   
                 4.68 (d, J = 47.3 Hz, 1H), 4.12 (d, J = 13.8 Hz, 1H), 3.71 (d, J = 13.9 Hz, 1H), 2.56 (s, 
               
               
                   
                 3H), 1.56 (dd, J = 7.1, 1.3 Hz, 3H), 0.91 (s, 9H). 
               
               
                 1104 
                 1H NMR (400 MHz, Methanol-d4) δ 8.48 (s, 1H), 7.88 (s, 1H), 7.69-7.63 (m, 1H), 
               
               
                   
                 7.62 (d, J = 2.3 Hz, 1H), 7.60-7.54 (m, 1H), 7.34 (t, J = 7.8 Hz, 1H), 6.74 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 6.21 (s, 1H), 4.38 (d, J = 15.0 Hz, 1H), 4.09 (d, J = 15.0 Hz, 1H), 2.56 (s, 
               
               
                   
                 3H), 1.65 (s, 3H), 1.40-1.25 (m, 2H), 1.13 (s, 3H), 1.11 (s, 3H), 1.09-0.97 (m, 2H). 
               
               
                 1105 
                 1H NMR (400 MHz, Methanol-d4) δ 9.86 (s, 1H), 9.30 (s, 1H), 9.07-8.98 (m, 2H), 
               
               
                   
                 8.95 (d, J = 8.0 Hz, 1H), 8.70 (t, J = 7.8 Hz, 1H), 8.12 (s, 1H), 7.59 (s, 1H), 5.79 (d, J = 14.9 Hz, 
               
               
                   
                 1H), 5.43 (d, J = 15.1 Hz, 1H), 3.93 (s, 3H), 2.93-2.88 (m, 1H), 2.59 (s, 2H), 
               
               
                   
                 2.49 (d, J = 6.7 Hz, 6H), 2.37 (s, 2H), 1.89 (d, J = 7.8 Hz, 2H), 1.69 (d, J = 5.2 Hz, 
               
               
                   
                 2H). 
               
               
                 1106 
                 1H NMR (400 MHz, Methanol-d4) δ 9.82 (s, 1H), 9.21 (s, 1H), 9.02 (d, J = 7.8 Hz, 
               
               
                   
                 1H), 8.99 (s, 1H), 8.95 (d, J = 8.0 Hz, 1H), 8.70 (t, J = 8.0 Hz, 1H), 8.10 (s, 1H), 
               
               
                   
                 7.61 (s, 1H), 6.40-6.31 (m, 1H), 6.05 (d, J = 46.9 Hz, 1H), 6.04 (d, J = 46.9 Hz, 1H), 
               
               
                   
                 5.75 (d, J = 14.8 Hz, 1H), 5.41 (d, J = 15.1 Hz, 1H), 4.66 (d, J = 7.2 Hz, 5H), 3.92 (s, 3H), 
               
               
                   
                 2.92 (d, J = 7.1 Hz, 3H), 2.47 (d, J = 6.2 Hz, 6H). 
               
               
                 1107 
                 1H NMR (400 MHz, Methanol-d4) δ 9.86 (s, 1H), 9.18 (s, 1H), 9.05-8.96 (m, 2H), 
               
               
                   
                 8.91 (d, J = 7.7 Hz, 1H), 8.76-8.58 (m, 1H), 8.10 (s, 1H), 7.58 (s, 1H), 5.73 (d, J = 14.8 Hz, 
               
               
                   
                 1H), 5.47 (d, J = 15.0 Hz, 1H), 4.04 (s, 1H), 3.92 (s, 3H), 3.72 (s, 6H), 
               
               
                   
                 2.48 (s, 3H), 2.47 (s, 3H). 
               
               
                 1108 
                 1H NMR (400 MHz, Methanol-d4) δ 8.52 (s, 1H), 7.85 (s, 1H), 7.67 (dd, J = 7.8, 1.3 Hz, 
               
               
                   
                 1H), 7.65 (d, J = 2.2 Hz, 1H), 7.59 (dd, J = 8.0, 1.3 Hz, 1H), 7.34 (t, J = 7.8 Hz, 
               
               
                   
                 1H), 6.82 (d, J = 2.3 Hz, 1H), 6.26 (s, 1H), 4.12 (d, J = 13.9 Hz, 1H), 3.75 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 2.69 (s, 1H), 2.57 (s, 3H), 2.37 (s, 6H), 0.91 (s, 9H). 
               
               
                 1109 
                 1H NMR (400 MHz, Methanol-d4) δ 8.18 (s, 1H), 7.63 (s, 1H), 7.37-7.31 (m, 2H), 
               
               
                   
                 7.28 (dd, J = 8.0, 1.3 Hz, 1H), 7.02 (t, J = 7.8 Hz, 1H), 6.49 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 5.92 (s, 1H), 3.82 (d, J = 13.9 Hz, 1H), 3.39 (d, J = 13.9 Hz, 1H), 2.23 (s, 3H), 
               
               
                   
                 1.28-1.16 (m, 1H), 0.94-0.86 (m, 2H), 0.77-0.65 (m, 2H), 0.59 (s, 9H), 0.25-0.13 (m, 2H), 
               
               
                   
                 0.09-−0.08 (m, 2H). 
               
               
                 1110 
                 1H NMR (400 MHz, Methanol-d4) δ 8.48 (s, 1H), 8.13 (s, 1H), 7.60 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.54-7.43 (m, 2H), 7.33 (m, 2H), 6.99 (d, J = 2.1 Hz, 1H), 6.44 (s, 1H), 4.09 (d, 
               
               
                   
                 J = 13.8 Hz, 1H), 3.77 (d, J = 13.8 Hz, 1H), 2.46 (s, 3H), 2.00 (m, 4H), 0.97 (s, 9H). 
               
               
                 1111 
                 1H NMR (400 MHz, Methanol-d4) δ 8.36 (s, 1H), 7.96 (s, 1H), 7.76 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.51-7.44 (m, 2H), 7.38-7.29 (m, 2H), 7.14 (d, J = 2.5 Hz, 1H), 5.95 (t, J = 54.8 Hz, 
               
               
                   
                 1H), 3.90 (d, J = 13.6 Hz, 1H), 3.68 (d, J = 13.7 Hz, 1H), 1.59-1.48 (m, 4H), 
               
               
                   
                 0.95 (s, 9H). 
               
               
                 1112 
                 1H NMR (400 MHz, DMSO-d6) δ 8.41 (s, 1H), 8.26 (s, 1H), 7.80-7.71 (m, 1H), 
               
               
                   
                 7.71-7.63 (m, 1H), 7.62-7.59 (m, 1H), 7.42 (s, 1H), 7.34-7.27 (m, 1H), 7.21 (t, 1H), 
               
               
                   
                 7.03 (s, 1H), 6.41 (d, 1H), 3.94-3.81 (m, 1H), 3.43-3.34 (m, 1H), 1.78-1.71 (m, 2H), 
               
               
                   
                 1.71-1.64 (m, 2H), 0.78 (s, 9H). 
               
               
                 1113 
                 1H NMR (400 MHz, Chloroform-d) δ 8.20 (s, 1H), 7.92-7.86 (m, 1H), 7.76-7.65 (m, 
               
               
                   
                 1H), 7.52-7.48 (m, 1H), 7.38-7.28 (m, 3H), 7.23-7.14 (m, 1H), 6.45-6.35 (m, 1H), 
               
               
                   
                 4.03-3.90 (m, 1H), 3.88-3.74 (m, 1H), 3.14 (s, 3H), 2.90 (s, 3H), 1.75-1.62 (m, 
               
               
                   
                 4H), 0.99 (s, 9H). 
               
               
                 1114 
                 1H NMR (400 MHz, Chloroform-d) δ 8.00-7.89 (m, 2H), 7.77 (s, 1H), 7.67-7.58 (m, 
               
               
                   
                 1H), 7.44 (s, 1H), 7.24-7.14 (m, 3H), 6.92 (s, 1H), 6.98-6.86 (m, 1H), 6.43-6.32 (m, 
               
               
                   
                 1H), 4.06 (d, 1H), 3.55 (d, 1H), 3.03 (d, 3H), 1.76-1.62 (m, 4H), 0.85 (d, 9H). 
               
               
                 1115 
                 1H NMR (400 MHz, Chloroform-d) δ 9.18-9.06 (m, 1H), 8.06-7.94 (m, 2H), 7.82 (s, 
               
               
                   
                 1H), 7.76-7.62 (m, 1H), 7.49-7.41 (m, 1H), 7.24-7.23 (m, 1H), 6.98-6.86 (m, 1H), 
               
               
                   
                 6.57-6.45 (m, 1H), 6.39 (s, 1H), 4.02 (d, 1H), 3.60 (d, 1H), 1.79-1.71 (m, 2H), 
               
               
                   
                 1.70-1.60 (m, 2H), 0.86 (s, 9H). 
               
               
                 1116 
                 1H NMR (400 MHz, Chloroform-d) δ8.85-8.71 (m, 1H), 8.21 (d, 1H), 8.13 (s, 1H), 
               
               
                   
                 7.83-7.73 (m, 1H), 7.63 (s, 1H), 7.37 (s, 1H), 7.18 (s, 1H), 7.10 (dd, 1H), 
               
               
                   
                 6.83-6.76 (m, 1H), 6.29-6.08 (m, 1H), 4.10 (d, 1H), 3.56 (d, 1H), 2.99 (d, 3H), 1.76-1.56 (m, 
               
               
                   
                 4H), 0.91 (s, 9H). 
               
               
                 1117 
                 1H NMR (400 MHz, Chloroform-d) δ8.94-8.75 (m, 1H), 8.30 (d, 1H), 8.15 (s, 1H), 
               
               
                   
                 7.88-7.79 (m, 1H), 7.64 (s, 1H), 7.39 (s, 1H), 7.22 (s, 1H), 7.13 (dd, 1H), 
               
               
                   
                 6.80-6.71 (m, 1H), 6.33-6.24 (m, 1H), 6.23-6.10 (m, 1H), 4.10 (s, 1H), 3.57 (d, 1H), 
               
               
                   
                 1.75-1.55 (m, 4H), 0.92 (s, 9H). 
               
               
                 1118 
                 1H NMR (400 MHz, Methanol-d4) δ 8.69 (d, J = 5.1 Hz, 1H), 8.47 (s, 1H), 
               
               
                   
                 8.18-8.09 (m, 2H), 7.67-7.56 (m, 2H), 7.44 (dd, J = 6.5, 2.8 Hz, 1H), 7.39-7.32 (m, 2H), 
               
               
                   
                 7.04 (d, J = 2.3 Hz, 1H), 6.35 (s, 1H), 3.94 (s, 2H), 2.28 (s, 3H), 1.82-1.63 (m, 4H), 
               
               
                   
                 0.96 (s, 9H). 
               
               
                 1119 
                 1H NMR (400 MHz, Methanol-d4) δ 8.95 (s, 1H), 8.40 (s, 1H), 8.17 (s, 1H), 7.66 (d, J = 1.4 Hz, 
               
               
                   
                 1H), 7.55 (d, J = 2.3 Hz, 1H), 7.49-7.40 (m, 2H), 7.36 (t, J = 7.6 Hz, 1H), 
               
               
                   
                 7.01 (d, J = 2.3 Hz, 1H), 6.37 (s, 1H), 4.00 (s, 3H), 3.90 (d, J = 13.9 Hz, 1H), 3.85 (d, J = 14.0 Hz, 
               
               
                   
                 1H), 2.44 (s, 3H), 1.82-1.73 (m, 2H), 1.67 (s, 2H), 0.93 (s, 9H). 
               
               
                 1120 
                 1H NMR (400 MHz, Methanol-d4) δ 9.03 (s, 1H), 8.49 (s, 1H), 8.22 (s, 1H), 7.60 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.57 (s, 1H), 7.48 (dd, J = 6.9, 2.2 Hz, 1H), 7.44-7.34 (m, 2H), 
               
               
                   
                 7.13 (d, J = 2.3 Hz, 1H), 6.38 (s, 1H), 4.02 (d, J = 14.0 Hz, 1H), 3.89 (d, J = 14.0 Hz, 1H), 
               
               
                   
                 3.63 (s, 3H), 2.25 (s, 3H), 1.82-1.66 (m, 4H), 0.97 (s, 9H). 
               
               
                 1121 
                 1H NMR (400 MHz, Methanol-d4) δ 9.28 (d, J = 5.3 Hz, 1H), 9.22 (s, 1H), 8.51 (s, 
               
               
                   
                 1H), 8.16 (s, 1H), 7.75 (dd, J = 5.4, 2.3 Hz, 1H), 7.66 (d, J = 2.2 Hz, 1H), 7.43 (d, J = 7.0 Hz, 
               
               
                   
                 1H), 7.37 (t, J = 7.6 Hz, 1H), 7.33 (d, J = 7.2 Hz, 1H), 7.03 (d, J = 2.2 Hz, 1H), 
               
               
                   
                 6.36 (s, 1H), 4.01 (d, J = 13.8 Hz, 1H), 3.90 (d, J = 13.9 Hz, 1H), 2.31 (s, 3H), 
               
               
                   
                 1.82-1.62 (m, 4H), 0.94 (s, 9H). 
               
               
                 1122 
                 1H NMR (400 MHz, Methanol-d4) δ 9.02 (d, J = 0.9 Hz, 1H), 8.47 (s, 1H), 8.04 (s, 
               
               
                   
                 1H), 7.59 (d, J = 2.3 Hz, 1H), 7.56 (d, J = 1.6 Hz, 1H), 7.49 (dd, J = 7.3, 2.0 Hz, 1H), 
               
               
                   
                 7.44-7.33 (m, 2H), 7.09 (d, J = 2.2 Hz, 1H), 6.35 (s, 1H), 5.92 (t, J = 54.6 Hz, 1H), 
               
               
                   
                 3.98 (d, J = 14.0 Hz, 1H), 3.89 (d, J = 13.9 Hz, 1H), 3.62 (s, 3H), 2.25 (s, 3H), 
               
               
                   
                 1.62-1.48 (m, 4H), 0.96 (s, 9H). 
               
               
                 1123 
                 1H NMR (400 MHz, Methanol-d4) δ 9.29 (s, 1H), 9.23 (s, 1H), 8.51 (s, 1H), 8.00 (s, 
               
               
                   
                 1H), 7.76 (d, J = 4.8 Hz, 1H), 7.65 (d, J = 2.3 Hz, 1H), 7.44 (dd, J = 7.6, 1.6 Hz, 1H), 
               
               
                   
                 7.37 (t, J = 7.6 Hz, 1H), 7.32 (dd, J = 7.7, 1.7 Hz, 1H), 7.02 (d, J = 2.3 Hz, 1H), 
               
               
                   
                 6.35 (s, 1H), 5.94 (t, J = 54.6 Hz, 1H), 4.02 (d, J = 13.9 Hz, 1H), 3.89 (d, J = 14.0 Hz, 1H), 
               
               
                   
                 2.31 (s, 3H), 1.54 (s, 4H), 0.94 (s, 9H). 
               
               
                 1124 
                 1H NMR (400 MHz, Methanol-d4) δ 8.32 (s, 1H), 7.77 (d, J = 2.5 Hz, 1H), 7.73 (s, 
               
               
                   
                 1H), 7.47 (d, J = 7.5 Hz, 2H), 7.41-7.33 (m, 2H), 7.33-7.26 (m, 1H), 7.20 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.04 (s, 1H), 3.93 (d, J = 13.8 Hz, 1H), 3.64 (d, J = 13.8 Hz, 1H), 2.68 (s, 
               
               
                   
                 1H), 2.36 (s, 6H), 0.92 (s, 9H). 
               
               
                 1125 
                 1H NMR (400 MHz, Methanol-d4) δ 8.36 (s, 1H), 7.96 (s, 1H), 7.79 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.66 (dd, J = 7.8, 1.3 Hz, 1H), 7.59 (d, J = 7.8 Hz, 1H), 7.34 (t, J = 7.8 Hz, 1H), 
               
               
                   
                 6.96 (d, J = 2.5 Hz, 1H), 6.26 (s, 1H), 5.94 (t, J = 54.8 Hz, 1H), 4.27 (d, J = 14.9 Hz, 
               
               
                   
                 1H), 3.97 (d, J = 14.8 Hz, 1H), 2.57 (s, 3H), 1.52 (s, 4H), 1.08 (d, J = 5.7 Hz, 6H). 
               
               
                 1126 
                 1H NMR (400 MHz, Methanol-d4) δ 8.36 (s, 1H), 7.97 (s, 1H), 7.79 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.72-7.64 (m, 1H), 7.60 (dd, J = 7.9, 1.2 Hz, 1H), 7.34 (t, J = 7.8 Hz, 1H), 
               
               
                   
                 6.96 (d, J = 2.5 Hz, 1H), 6.26 (s, 1H), 5.95 (t, J = 54.8 Hz, 1H), 4.26 (d, J = 14.8 Hz, 1H), 
               
               
                   
                 3.97 (d, J = 14.9 Hz, 1H), 2.58 (s, 3H), 1.53 (s, 4H), 1.08 (d, J = 5.7 Hz, 6H). 
               
               
                 1127 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 8.04 (s, 1H), 7.78 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.25-6.95 (m, 4H), 6.24 (s, 1H), 3.89 (d, J = 13.7 Hz, 1H), 3.66 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 2.27 (d, J = 1.9 Hz, 3H), 1.82-1.57 (m, 4H), 0.89 (s, 9H). 
               
               
                 1128 
                 1H NMR (400 MHz, Methanol-d4) δ 8.33 (s, 1H), 8.07 (s, 1H), 7.79 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.49-7.44 (m, 1H), 7.44-7.35 (m, 2H), 7.28-7.21 (m, 2H), 6.13 (s, 1H), 
               
               
                   
                 3.95 (d, J = 13.9 Hz, 1H), 3.64 (d, J = 13.8 Hz, 1H), 1.74 (m, 2H), 1.70 (m, 2H), 1.66 (m, 
               
               
                   
                 2H), 1.50-1.37 (m, 2H), 0.93 (s, 9H). 
               
               
                 1129 
                 1H NMR (400 MHz, Methanol-d4) δ 8.36 (s, 1H), 7.83-7.76 (m, 2H), 7.47 (d, J = 1.9 Hz, 
               
               
                   
                 1H), 7.42-7.34 (m, 2H), 7.26-7.19 (m, 2H), 6.09 (s, 1H), 3.96 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 3.67 (d, J = 13.9 Hz, 1H), 2.68 (s, 1H), 2.37 (s, 6H), 1.75-1.64 (m, 2H), 
               
               
                   
                 1.52-1.43 (m, 1H), 1.43-1.36 (m, 1H), 0.93 (s, 9H). 
               
               
                 1130 
                 1H NMR (400 MHz, Methanol-d4) δ 8.31 (s, 1H), 7.78 (s, 1H), 7.76 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.48 (dd, J = 8.6, 5.3 Hz, 2H), 7.17 (d, J = 2.5 Hz, 1H), 7.09 (t, J = 8.7 Hz, 2H), 
               
               
                   
                 6.04 (s, 1H), 3.93 (d, J = 13.9 Hz, 1H), 3.63 (d, J = 13.8 Hz, 1H), 2.68 (s, 1H), 2.36 (s, 
               
               
                   
                 6H), 0.92 (s, 9H). 
               
               
                 1131 
                 1H NMR (400 MHz, Methanol-d4) δ 8.23 (s, 1H), 8.22 (s, 1H), 7.98 (s, 1H), 7.68 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.52 (d, J = 7.8 Hz, 1H), 7.29 (d, J = 7.6 Hz, 1H), 7.24 (s, 1H), 7.20 (t, J = 7.8 Hz, 
               
               
                   
                 1H), 6.97 (d, J = 2.6 Hz, 1H), 6.27 (s, 1H), 3.74 (d, J = 13.8 Hz, 1H), 3.53 (d, 
               
               
                   
                 J = 13.8 Hz, 1H), 2.36 (s, 3H), 1.69-1.54 (m, 4H), 0.73 (s, 9H). 
               
               
                 1132 
                 1H NMR (400 MHz, Methanol-d4) δ 8.26 (s, 1H), 7.97 (s, 1H), 7.69 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.63 (d, J = 2.1 Hz, 1H), 7.29 (d, J = 7.1 Hz, 1H), 7.23 (d, J = 7.3 Hz, 1H), 7.15 (t, 
               
               
                   
                 J = 7.7 Hz, 1H), 7.07 (d, J = 2.4 Hz, 1H), 6.33 (d, J = 2.2 Hz, 1H), 6.24 (s, 1H), 
               
               
                   
                 3.73 (d, J = 13.8 Hz, 1H), 3.66 (d, J = 14.3 Hz, 1H), 2.30 (s, 3H), 1.70-1.55 (m, 4H), 
               
               
                   
                 0.79 (s, 9H). 
               
               
                 1133 
                 1H NMR (400 MHz, Methanol-d4) δ 8.36 (s, 1H), 8.05 (s, 1H), 7.79 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.73 (s, 2H), 7.32 (dd, J = 7.0, 2.1 Hz, 1H), 7.26-7.15 (m, 2H), 7.14 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.33 (s, 1H), 3.86 (d, J = 13.8 Hz, 1H), 3.72 (d, J = 13.8 Hz, 1H), 2.39 (s, 
               
               
                   
                 3H), 1.80-1.60 (m, 4H), 0.87 (s, 9H). 
               
               
                 1134 
                 1H NMR (400 MHz, Methanol-d4) δ 9.33 (d, J = 5.5 Hz, 1H), 9.28 (s, 1H), 8.38 (s, 
               
               
                   
                 1H), 8.18 (s, 1H), 7.86 (dd, J = 5.4, 2.3 Hz, 1H), 7.80 (d, J = 2.5 Hz, 1H), 
               
               
                   
                 7.49-7.42 (m, 1H), 7.38 (t, J = 7.6 Hz, 1H), 7.36-7.32 (m, 1H), 7.23 (d, J = 2.5 Hz, 1H), 6.37 (s, 
               
               
                   
                 1H), 3.86 (d, J = 14.0 Hz, 1H), 3.79 (d, J = 14.0 Hz, 1H), 2.34 (s, 3H), 1.81-1.60 (m, 
               
               
                   
                 4H), 0.91 (s, 9H). 
               
               
                 1135 
                 1H NMR (400 MHz, Methanol-d4) δ 9.02 (d, J = 1.4 Hz, 1H), 8.29 (s, 1H), 8.22 (s, 
               
               
                   
                 1H), 7.68 (d, J = 2.5 Hz, 1H), 7.57 (d, J = 1.5 Hz, 1H), 7.50 (dd, J = 7.8, 1.7 Hz, 1H), 
               
               
                   
                 7.44-7.33 (m, 2H), 7.28 (d, J = 2.5 Hz, 1H), 6.37 (s, 1H), 3.83 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 3.72 (d, J = 13.9 Hz, 1H), 3.63 (s, 3H), 2.27 (s, 3H), 1.82-1.60 (m, 4H), 0.93 (s, 9H). 
               
               
                 1136 
                 1H NMR (400 MHz, Methanol-d4) δ 8.85-8.74 (m, 2H), 8.43 (dt, J = 8.0, 1.8 Hz, 
               
               
                   
                 1H), 8.31 (s, 1H), 8.19 (s, 1H), 8.02 (dd, J = 8.1, 5.6 Hz, 1H), 7.73 (d, J = 2.5 Hz, 1H), 
               
               
                   
                 7.49-7.41 (m, 1H), 7.37 (t, J = 7.7 Hz, 1H), 7.32 (dd, J = 7.6, 1.5 Hz, 1H), 7.23 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.37 (s, 1H), 3.78 (s, 2H), 2.33 (s, 3H), 1.84-1.55 (m, 4H), 0.92 (s, 
               
               
                   
                 9H). 
               
               
                 1137 
                 1H NMR (400 MHz, Methanol-d4) δ 8.85 (d, J = 6.0 Hz, 2H), 8.30 (s, 1H), 8.19 (s, 
               
               
                   
                 1H), 7.97 (d, J = 6.3 Hz, 2H), 7.72 (d, J = 2.5 Hz, 1H), 7.48 (d, J = 7.7 Hz, 1H), 7.40 (t, 
               
               
                   
                 J = 7.6 Hz, 1H), 7.35 (d, J = 7.6 Hz, 1H), 7.21 (d, J = 2.5 Hz, 1H), 6.37 (s, 1H), 3.76 (s, 
               
               
                   
                 2H), 2.37 (s, 3H), 1.86-1.58 (m, 4H), 0.91 (s, 9H). 
               
               
                 1138 
                 1H NMR (400 MHz, Methanol-d4) δ 8.37 (s, 1H), 8.04 (s, 1H), 7.79 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.71 (s, 1H), 7.55 (s, 1H), 7.34-7.26 (m, 1H), 7.23-7.15 (m, 2H), 7.14 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.32 (s, 1H), 3.94 (s, 3H), 3.84 (d, J = 13.8 Hz, 1H), 3.73 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 2.39 (s, 3H), 1.84-1.59 (m, 4H), 0.88 (s, 9H). 
               
               
                 1139 
                 1H NMR (400 MHz, Methanol-d4) δ 8.33 (s, 1H), 7.99 (s, 1H), 7.76 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.62 (d, J = 1.4 Hz, 1H), 7.57-7.44 (m, 2H), 7.00 (d, J = 2.5 Hz, 1H), 6.25 (s, 
               
               
                   
                 1H), 5.94 (t, J = 54.7 Hz, 1H), 3.90 (d, J = 13.8 Hz, 1H), 3.58 (d, J = 13.7 Hz, 1H), 
               
               
                   
                 2.42 (s, 3H), 1.53 (s, 4H), 0.87 (s, 9H). 
               
               
                 1140 
                 1H NMR (400 MHz, Methanol-d4) δ 8.34 (s, 1H), 8.14 (s, 1H), 7.76 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.63 (d, J = 1.5 Hz, 1H), 7.58-7.52 (m, 1H), 7.50 (d, J = 8.0 Hz, 1H), 7.02 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.27 (s, 1H), 3.90 (d, J = 13.8 Hz, 1H), 3.60 (d, J = 13.8 Hz, 1H), 
               
               
                   
                 2.42 (s, 3H), 1.81-1.61 (m, 4H), 0.87 (s, 9H). 
               
               
                 1141 
                 1H NMR (400 MHz, Methanol-d4) δ 8.86 (d, J = 6.4 Hz, 2H), 8.30 (s, 1H), 8.06 (s, 
               
               
                   
                 1H), 7.99 (d, J = 6.5 Hz, 2H), 7.73 (d, J = 2.5 Hz, 1H), 7.49 (d, J = 8.4 Hz, 1H), 7.40 (t, 
               
               
                   
                 J = 7.6 Hz, 1H), 7.37-7.32 (m, 1H), 7.20 (d, J = 2.5 Hz, 1H), 6.36 (s, 1H), 5.95 (t, J = 54.6 Hz, 
               
               
                   
                 1H), 3.83-3.69 (m, 2H), 2.37 (s, 3H), 1.54 (d, J = 6.3 Hz, 4H), 0.90 (s, 9H). 
               
               
                 1142 
                 1H NMR (400 MHz, Methanol-d4) δ 8.39 (s, 1H), 7.90 (s, 1H), 7.80 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.72 (s, 1H), 7.56 (s, 1H), 7.30 (dd, J = 7.1, 2.0 Hz, 1H), 7.23-7.15 (m, 2H), 
               
               
                   
                 7.14 (d, J = 2.5 Hz, 1H), 6.31 (s, 1H), 5.94 (t, J = 54.7 Hz, 1H), 3.95 (s, 3H), 3.89 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 3.73 (d, J = 13.9 Hz, 1H), 3.33-3.27 (m, 7H), 2.38 (s, 3H), 1.52 (s, 
               
               
                   
                 4H), 0.87 (s, 9H). 
               
               
                 1143 
                 1H NMR (400 MHz, Methanol-d4) δ 8.33 (s, 1H), 8.03 (s, 1H), 7.76 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.65 (d, J = 2.2 Hz, 1H), 7.38 (d, J = 7.5 Hz, 1H), 7.29 (d, J = 7.4 Hz, 1H), 7.22 (t, 
               
               
                   
                 J = 7.7 Hz, 1H), 7.15 (d, J = 2.5 Hz, 1H), 6.35 (d, J = 2.2 Hz, 1H), 6.32 (s, 1H), 3.94 (s, 
               
               
                   
                 3H), 3.79 (d, J = 13.8 Hz, 1H), 3.73 (d, J = 13.8 Hz, 1H), 2.40 (s, 3H), 1.82-1.58 (m, 
               
               
                   
                 4H), 0.88 (s, 9H). 
               
               
                 1144 
                 1H NMR (400 MHz, Methanol-d4) δ 8.80-8.72 (m, 1H), 8.36 (t, J = 7.9 Hz, 1H), 
               
               
                   
                 8.30 (s, 1H), 8.18 (s, 1H), 7.81 (dd, J = 15.7, 7.6 Hz, 2H), 7.72 (d, J = 2.5 Hz, 1H), 
               
               
                   
                 7.56-7.47 (m, 1H), 7.44-7.34 (m, 2H), 7.25 (d, J = 2.5 Hz, 1H), 6.38 (s, 1H), 
               
               
                   
                 3.86-3.68 (m, 2H), 2.33 (s, 3H), 1.85-1.61 (m, 4H), 0.92 (s, 9H). 
               
               
                 1145 
                 1H NMR (400 MHz, Methanol-d4) δ 8.98 (s, 1H), 8.28 (s, 1H), 8.19 (s, 1H), 7.68 (d, J = 2.0 Hz, 
               
               
                   
                 2H), 7.47 (d, J = 7.6 Hz, 1H), 7.42 (d, J = 7.0 Hz, 1H), 7.36 (t, J = 7.7 Hz, 
               
               
                   
                 1H), 7.22 (d, J = 2.5 Hz, 1H), 6.38 (s, 1H), 4.01 (s, 3H), 3.82-3.65 (m, 2H), 2.45 (s, 
               
               
                   
                 3H), 1.86-1.59 (m, 4H), 0.90 (s, 9H). 
               
               
                 1146 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 7.88 (s, 1H), 7.77 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.65 (d, J = 7.8 Hz, 1H), 7.59 (d, J = 7.7 Hz, 1H), 7.33 (t, J = 7.8 Hz, 1H), 6.92 (d, 
               
               
                   
                 J = 2.5 Hz, 1H), 6.21 (s, 1H), 4.25 (d, J = 14.9 Hz, 1H), 3.97 (d, J = 14.9 Hz, 1H), 
               
               
                   
                 2.57 (s, 3H), 1.65 (s, 3H), 1.35-1.28 (m, 2H), 1.08 (s, 3H), 1.07 (s, 3H), 1.05-1.02 (m, 
               
               
                   
                 2H). 
               
               
                 1147 
                 1H NMR (400 MHz, Methanol-d4) δ 8.37 (d, J = 1.1 Hz, 1H), 7.94 (s, 1H), 7.80 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.66 (d, J = 7.7 Hz, 1H), 7.62 (d, J = 7.8 Hz, 1H), 7.34 (t, J = 7.9 Hz, 1H), 
               
               
                   
                 6.99 (d, J = 2.4 Hz, 1H), 6.27 (s, 1H), 4.61 (d, J = 48.6 Hz, 2H), 3.97 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 3.60 (d, J = 13.8 Hz, 1H), 2.57 (s, 3H), 1.53-1.43 (m, 2H), 1.39-1.29 (m, 2H), 
               
               
                   
                 0.88 (s, 9H). 
               
               
                 1148 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 7.91 (s, 1H), 7.78 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.65 (d, J = 7.7 Hz, 1H), 7.61 (d, J = 8.0 Hz, 1H), 7.34 (t, J = 7.9 Hz, 1H), 6.96 (d, 
               
               
                   
                 J = 2.4 Hz, 1H), 6.23 (s, 1H), 3.94 (d, J = 13.8 Hz, 1H), 3.59 (d, J = 13.8 Hz, 1H), 
               
               
                   
                 2.57 (s, 3H), 1.66 (s, 3H), 1.39-1.22 (m, 2H), 1.14-0.98 (m, 2H), 0.87 (s, 9H). 
               
               
                 1149 
                 1H NMR (400 MHz, Methanol-d4) δ 8.38 (d, J = 1.1 Hz, 1H), 7.95 (s, 1H), 7.81 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.66 (d, J = 7.9 Hz, 1H), 7.63 (d, J = 8.0 Hz, 1H), 7.35 (t, J = 7.8 Hz, 1H), 
               
               
                   
                 7.02 (d, J = 2.4 Hz, 1H), 6.30 (s, 1H), 5.45-5.16 (m, 1H), 5.03-4.91 (m, 2H), 
               
               
                   
                 4.90-4.76 (m, 2H), 3.98 (d, J = 13.9 Hz, 1H), 3.60 (d, J = 13.8 Hz, 1H), 2.57 (s, 3H), 0.88 (s, 
               
               
                   
                 9H). 
               
               
                 1150 
                 1H NMR (400 MHz, Methanol-d4) δ 8.37 (s, 1H), 7.88 (s, 1H), 7.80 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 7.66 (d, J = 7.7 Hz, 1H), 7.62 (d, J = 7.7 Hz, 1H), 7.34 (t, J = 7.8 Hz, 1H), 7.00 (d, 
               
               
                   
                 J = 2.4 Hz, 1H), 6.28 (s, 1H), 5.08-4.92 (m, 1H), 4.70 (d, J = 46.9 Hz, 1H), 4.68 (d, J = 47.2 Hz, 
               
               
                   
                 1H), 3.97 (d, J = 13.8 Hz, 1H), 3.59 (d, J = 13.8 Hz, 1H), 2.57 (s, 3H), 
               
               
                   
                 1.56 (dd, J = 7.0, 1.3 Hz, 3H), 0.87 (d, J = 1.3 Hz, 9H). 
               
               
                 1151 
                 1H NMR (400 MHz, Methanol-d4) δ 8.37 (s, 1H), 7.83 (s, 1H), 7.78 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.69-7.62 (m, 1H), 7.57 (d, J = 7.9 Hz, 1H), 7.34 (t, J = 7.9 Hz, 1H), 6.94 (d, J = 2.4 Hz, 
               
               
                   
                 1H), 6.23 (s, 1H), 4.24 (d, J = 14.8 Hz, 1H), 4.01 (d, J = 14.9 Hz, 1H), 2.68 (s, 
               
               
                   
                 1H), 2.58 (s, 3H), 2.37 (s, 6H), 1.09 (s, 3H), 1.07 (s, 3H). 
               
               
                 1152 
                 1H NMR (400 MHz, Methanol-d4) δ 8.36 (s, 1H), 7.93 (s, 1H), 7.78 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.65 (d, J = 8.0 Hz, 1H), 7.60 (d, J = 7.6 Hz, 1H), 7.34 (t, J = 7.9 Hz, 1H), 6.94 (d, 
               
               
                   
                 J = 2.5 Hz, 1H), 6.23 (s, 1H), 4.28 (d, J = 14.8 Hz, 1H), 3.96 (d, J = 14.8 Hz, 1H), 
               
               
                   
                 2.57 (s, 3H), 1.60-1.48 (m, 1H), 1.26-1.18 (m, 2H), 1.09 (s, 3H), 1.07 (s, 3H), 1.01 (d, J = 1.9 Hz, 
               
               
                   
                 2H), 0.59-0.46 (m, 2H), 0.36-0.29 (m, 2H). 
               
               
                 1153 
                 1H NMR (400 MHz, Methanol-d4) δ 8.34 (s, 1H), 7.89 (s, 1H), 7.78 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.72 (s, 2H), 7.31 (dd, J = 7.3, 1.5 Hz, 1H), 7.27-7.15 (m, 2H), 7.11 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.30 (s, 1H), 5.94 (t, J = 54.7 Hz, 1H), 3.84 (d, J = 13.8 Hz, 1H), 3.69 (d, J = 13.8 Hz, 
               
               
                   
                 1H), 2.39 (s, 3H), 1.52 (s, 4H), 0.87 (s, 9H). 
               
               
                 1154 
                 1H NMR (400 MHz, Methanol-d4) δ 9.04-8.99 (m, 1H), 8.29 (s, 1H), 8.05 (s, 1H), 
               
               
                   
                 7.67 (d, J = 2.5 Hz, 1H), 7.57 (d, J = 1.6 Hz, 1H), 7.54-7.48 (m, 1H), 7.40 (t, J = 7.6 Hz, 
               
               
                   
                 1H), 7.35 (dd, J = 7.7, 1.7 Hz, 1H), 7.26 (d, J = 2.5 Hz, 1H), 6.34 (s, 1H), 5.93 (t, J = 54.6 Hz, 
               
               
                   
                 1H), 3.80 (d, J = 13.9 Hz, 1H), 3.73 (d, J = 13.8 Hz, 1H), 3.63 (d, J = 0.6 Hz, 
               
               
                   
                 3H), 2.26 (s, 3H), 1.53 (q, J = 8.2, 6.7 Hz, 4H), 0.93 (s, 9H). 
               
               
                 1155 
                 1H NMR (400 MHz, Methanol-d4) δ 9.30 (d, J = 5.4 Hz, 1H), 9.26 (s, 1H), 8.36 (s, 
               
               
                   
                 1H), 8.01 (s, 1H), 7.82 (dd, J = 5.4, 2.3 Hz, 1H), 7.78 (d, J = 2.5 Hz, 1H), 7.46 (d, J = 6.7 Hz, 
               
               
                   
                 1H), 7.38 (t, J = 7.7 Hz, 1H), 7.35-7.28 (m, 1H), 7.20 (d, J = 2.6 Hz, 1H), 
               
               
                   
                 6.35 (s, 1H), 5.95 (t, J = 54.7 Hz, 1H), 3.85 (d, J = 13.9 Hz, 1H), 3.75 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 2.33 (s, 3H), 1.54 (s, 4H), 0.91 (s, 9H). 
               
               
                 1156 
                 1H NMR (400 MHz, Methanol-d4) δ 8.33 (s, 1H), 7.85 (s, 1H), 7.76 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.66 (d, J = 7.8 Hz, 1H), 7.61 (d, J = 7.8 Hz, 1H), 7.34 (t, J = 7.8 Hz, 1H), 6.95 (d, 
               
               
                   
                 J = 2.5 Hz, 1H), 6.25 (s, 1H), 3.90 (d, J = 13.8 Hz, 1H), 3.58 (d, J = 13.8 Hz, 1H), 
               
               
                   
                 2.69 (s, 1H), 2.58 (s, 3H), 2.37 (d, J = 0.9 Hz, 6H), 0.86 (s, 9H). 
               
               
                 1157 
                 1H NMR (400 MHz, Methanol-d4) δ 8.01 (s, 1H), 7.63 (s, 1H), 7.45 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.36-7.27 (m, 2H), 7.02 (t, J = 7.8 Hz, 1H), 6.64 (d, J = 2.5 Hz, 1H), 5.92 (s, 
               
               
                   
                 1H), 3.62 (d, J = 13.8 Hz, 1H), 3.24 (d, J = 13.8 Hz, 1H), 2.25 (s, 3H), 1.28-1.16 (m, 
               
               
                   
                 1H), 0.94-0.85 (m, 2H), 0.72-0.65 (m, 2H), 0.54 (s, 9H), 0.23-0.16 (m, 2H), 
               
               
                   
                 0.06-−0.09 (m, 2H). 
               
               
                 1158 
                 1H NMR (400 MHz, Methanol-d4) δ 8.36-8.30 (m, 2H), 7.93 (s, 1H), 7.79 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.61 (d, J = 7.5 Hz, 1H), 7.39 (d, J = 7.7 Hz, 1H), 7.33 (s, 1H), 7.30 (t, J = 7.8 Hz, 
               
               
                   
                 1H), 7.07 (d, J = 2.5 Hz, 1H), 6.35 (s, 1H), 5.94 (t, J = 54.7 Hz, 1H), 3.87 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 3.62 (d, J = 13.8 Hz, 1H), 2.45 (s, 3H), 1.52 (s, 4H), 0.83 (s, 9H). 
               
               
                 1159 
                 1H NMR (400 MHz, Methanol-d4) δ 8.32 (s, 1H), 7.74 (d, J = 2.5 Hz, 1H), 
               
               
                   
                 7.58-7.40 (m, 2H), 7.36-7.25 (m, 2H), 7.07 (d, J = 2.5 Hz, 1H), 6.32 (s, 1H), 3.90 (d, J = 13.6 Hz, 
               
               
                   
                 1H), 3.58 (d, J = 13.6 Hz, 1H), 1.60 (s, 3H), 1.32 (s, 2H), 1.10 (s, 2H), 0.91 (s, 
               
               
                   
                 9H). 
               
               
                 1160 
                 1H NMR (400 MHz, Methanol-d4) δ 8.35 (s, 1H), 7.76 (d, J = 2.5 Hz, 1H), 7.53 (dd, J = 6.9, 
               
               
                   
                 2.5 Hz, 1H), 7.48-7.38 (m, 1H), 7.29 (ddd, J = 6.5, 3.9, 2.0 Hz, 2H), 7.03 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 6.33 (s, 1H), 3.98 (m, 4H), 3.54 (d, J = 13.6 Hz, 1H), 1.59 (s, 3H), 
               
               
                   
                 1.30 (s, 2H), 1.12-0.98 (m, 2H), 0.90 (s, 9H). 
               
               
                 1161 
                 1H NMR (400 MHz, Methanol-d4) δ 8.39 (s, 1H), 8.14 (s, 1H), 7.77 (d, J = 2.5 Hz, 
               
               
                   
                 1H), 7.58-7.41 (m, 2H), 7.39-7.24 (m, 2H), 7.17 (d, J = 2.5 Hz, 1H), 6.44 (s, 1H), 
               
               
                   
                 3.95 (d, J = 13.7 Hz, 1H), 3.68 (d, J = 13.7 Hz, 1H), 2.46 (s, 3H), 2.08-1.92 (m, 4H), 
               
               
                   
                 0.95 (s, 9H). 
               
               
                 1162 
                 1H NMR (400 MHz, Methanol-d4) δ 8.49 (s, 1H), 8.02 (s, 1H), 7.64 (t, J = 2.4 Hz, 
               
               
                   
                 2H), 7.39 (d, J = 6.9 Hz, 1H), 7.28 (d, J = 7.4 Hz, 1H), 7.22 (t, J = 7.7 Hz, 1H), 6.99 (d, 
               
               
                   
                 J = 2.3 Hz, 1H), 6.34 (d, J = 2.3 Hz, 1H), 6.32 (s, 1H), 3.99 (d, J = 13.9 Hz, 1H), 
               
               
                   
                 3.94 (s, 3H), 3.89 (d, J = 13.8 Hz, 1H), 2.39 (s, 3H), 1.82-1.62 (m, 4H), 0.93 (s, 9H). 
               
               
                 1163 
                 1H NMR (400 MHz, Methanol-d4) δ 8.49 (s, 1H), 8.04 (s, 1H), 7.71 (s, 1H), 7.65 (s, 
               
               
                   
                 1H), 7.39 (d, J = 7.5 Hz, 1H), 7.30 (d, J = 7.7 Hz, 1H), 7.24 (t, J = 7.4 Hz, 1H), 6.99 (s, 
               
               
                   
                 1H), 6.40 (s, 1H), 6.33 (s, 1H), 3.99 (d, J = 13.9 Hz, 1H), 3.88 (d, J = 14.0 Hz, 1H), 
               
               
                   
                 2.38 (s, 3H), 1.71 (d, J = 29.2 Hz, 4H), 0.92 (s, 9H). 
               
               
                 1164 
                 1H NMR (400 MHz, Methanol-d4) δ 8.48 (s, 1H), 8.04 (s, 1H), 7.71 (s, 2H), 7.64 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.32 (dd, J = 6.4, 2.6 Hz, 1H), 7.20 (d, J = 6.7 Hz, 2H), 6.94 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 6.32 (s, 1H), 4.01 (d, J = 13.8 Hz, 1H), 3.82 (d, J = 13.9 Hz, 1H), 2.38 (s, 
               
               
                   
                 3H), 1.71 (d, J = 30.2 Hz, 4H), 0.90 (s, 9H). 
               
               
                 1165 
                 1H NMR (400 MHz, Methanol-d4) δ 8.50 (s, 1H), 8.33 (s, 1H), 8.08 (s, 1H), 7.66 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.62 (d, J = 7.5 Hz, 1H), 7.40-7.35 (m, 1H), 7.34 (s, 1H), 7.30 (t, J = 7.8 Hz, 
               
               
                   
                 1H), 6.92 (d, J = 2.3 Hz, 1H), 6.37 (s, 1H), 4.06 (d, J = 13.9 Hz, 1H), 3.78 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 2.44 (s, 3H), 1.81-1.58 (m, 4H), 0.88 (s, 9H). 
               
               
                 1166 
                 1H NMR (400 MHz, Methanol-d4) δ 8.50 (s, 1H), 7.88 (s, 1H), 7.71 (s, 2H), 7.65 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 7.32 (dd, J = 6.9, 2.1 Hz, 1H), 7.25-7.14 (m, 2H), 6.95 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 6.31 (s, 1H), 5.94 (t, J = 54.7 Hz, 1H), 4.04 (d, J = 13.9 Hz, 1H), 3.83 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 2.38 (s, 3H), 1.53 (s, 4H), 0.91 (s, 9H). 
               
               
                 1167 
                 1H NMR (400 MHz, Methanol-d4) δ 8.49 (s, 1H), 8.33 (s, 1H), 7.92 (s, 1H), 7.65 (d, J = 2.2 Hz, 
               
               
                   
                 1H), 7.62 (d, J = 6.9 Hz, 1H), 7.37 (d, J = 7.7 Hz, 1H), 7.33 (s, 1H), 7.30 (t, J = 7.8 Hz, 
               
               
                   
                 1H), 6.91 (d, J = 2.3 Hz, 1H), 6.36 (s, 1H), 5.94 (t, J = 54.7 Hz, 1H), 4.05 (d, 
               
               
                   
                 J = 13.9 Hz, 1H), 3.76 (d, J = 13.9 Hz, 1H), 3.30 (q, J = 1.6 Hz, 7H), 2.43 (s, 3H), 
               
               
                   
                 1.53 (s, 4H), 0.88 (s, 9H). 
               
               
                 1168 
                 1H NMR (400 MHz, Methanol-d4) δ 8.52 (s, 1H), 7.70-7.63 (m, 3H), 7.35 (t, J = 7.8 Hz, 
               
               
                   
                 1H), 6.88 (d, J = 2.3 Hz, 1H), 6.27 (s, 1H), 5.89 (t, J = 54.1 Hz, 1H), 4.15 (d, J = 13.9 Hz, 
               
               
                   
                 1H), 3.73 (d, J = 13.9 Hz, 1H), 2.57 (s, 3H), 1.58 (s, 4H), 0.93 (s, 9H). 
               
               
                 1169 
                 1H NMR (400 MHz, Methanol-d4) δ 8.46 (s, 1H), 7.61 (m, 1H), 7.48 (m, 2H), 
               
               
                   
                 7.38-7.23 (m, 2H), 6.92 (d, J = 2.3 Hz, 1H), 6.33 (s, 1H), 4.07 (d, J = 13.8 Hz, 1H), 3.72 (d, 
               
               
                   
                 J = 13.8 Hz, 1H), 1.60 (s, 3H), 1.32 (s, 2H), 1.10 (s, 2H), 0.95 (s, 9H). 
               
               
                 1170 
                 1H NMR (400 MHz, Methanol-d4) δ 8.44 (s, 1H), 7.60 (d, J = 2.3 Hz, 1H), 7.51 (dd, J = 7.1, 
               
               
                   
                 2.3 Hz, 1H), 7.44 (dd, J = 7.5, 1.8 Hz, 1H), 7.30 (m, 2H), 6.84 (d, J = 2.3 Hz, 
               
               
                   
                 1H), 6.32 (s, 1H), 4.09 (d, J = 13.7 Hz, 1H), 3.98 (s, 3H), 3.65 (d, J = 13.7 Hz, 1H), 
               
               
                   
                 1.59 (s, 3H), 1.29 (m, 2H), 1.06 (m, 2H), 0.93 (s, 9H). 
               
               
                   
               
            
           
         
       
     
     Biological Assays 
     The following examples, from Examples 60 to 62, describe biological assays for measuring certain test compounds&#39; activity against TNFα, Cot (also known as Tpl2), and EGFR. As summarized in Table 3, the test compounds are effective inhibitors of Cot. 
     Example 60: Cot Monocyte TNFα Cell Based Assay 
     Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with Glutamax (10 mM HEPES, 1× Pen-Strep, 55 μM β-mercaptoethanol, 1 mM Sodium pyruvate) media containing 10% FBS to 0.125×10^6 cells/ml and recovered at 37° C. for 2 hours. The cell suspension was then plated at a density of 5,000 cells/well onto black 384 well Greiner clear bottom plates. Plates were pre-spotted with test compounds and serially diluted in DMSO where 200 nL/well were delivered using the Echo 550 acoustic liquid dispenser (Labcyte®) for a final DMSO concentration of 0.5%. Plated cells were treated with compound for 1 hour at 37° C. Cells were then stimulated with 50 pg/ml of LPS (Sigma) excluding outside columns of plate used for unstimulated cell control wells. Cells were incubated for an additional 4 hours at 37° C. Cells were then spun out of the media and 5 ul of sample were taken and analyzed for total TNFα content using the TR-FRET Human TNFα detection system (CisBio). This system utilizes two labeled antibodies (cryptate and XL665) that bind to two different epitopes of the TNFα molecule and produce FRET signal proportional to the concentration of TNFα in the sample. Detection antibodies are mixed 50:50 and 5 μL were dispensed into each well. Plates were covered with clear seals and incubated at room temp overnight. The following morning plates were read using an Envision 2103 Multilabeled reader (PerkinElmer) with excitation/emission/FRET emission at 340 nm/615 nm/665 nm, respectively. Fluorescence intensities at 615 nm and 665 nm emission wavelengths were expressed as a ratio (665 nm/615 nm). Percent of control was calculated as follows:
 
% Control=100×(Ratio Sample −Ratio 0% stimulation )/(Ratio 100% Stimulation −Ratio 0% Stimulation )
 
where unstimulated cells (0% stimulation) were the negative control and stimulated cells (100% stimulation) were used as the positive control.
 
     Example 61: High Throughput Cot Biochemical Assay 
     Human Cot enzyme activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Cot-catalyzes the phosphorylation of a XL665-labeled peptide substrate. Europium conjugated phospho-tyrosine specific antibody binds the resulting phosphorylated peptide. Formation of phosphorylated peptide is quantified by TR-FRET with Europium as the donor and XL665 the acceptor in a 2-step endpoint assay. Purified recombinant human Cot catalytic domain (30-397 amino acids) was purchased from Cama Biosciences. In brief, test compounds serially diluted in DMSO were delivered into Proxy white, low volume, 384 well plates using the Echo 550 acoustic liquid dispenser (Labcyte®). Cot enzyme and substrates were dispensed into assay plates using a Multi-Flo (Bio-Tek Instruments). The standard 5 μL reaction mixture contained 400 μM ATP, 1 μM STK3 peptide, 5 nM of Cot in reaction buffer (10 mM MOPS, pH 7.0, 0.02% NaN 3 , 0.5 mg/mL BSA, 10 mM MgOAc, 1 mM DTT, 0.025% NP-40, 1.5% glycerol) and 0.1% DMSO. After 2.5 hrs of incubation at room temperature, 5 μL of Stop and Detect Solution (1:200 Europium Cryptate labeled anti-phosphorylated peptide antibody solution and 125 nM strepavidin-XL665 Tracer in a 50 mM Hepes pH 7.0 detection buffer containing sufficient EDTA) was added. The plate was then further incubated for 120 minutes at room temperature and read using an Envision 2103 Multilabeled reader (PerkinElmer) with excitation/emission/FRET emission at 340 nm/615 nm/665 nm, respectively. Fluorescence intensities at 615 nm and 665 nm emission wavelengths were expressed as a ratio (665 nm/615 nm). Percent inhibition was calculated as follows:
 
% Inhibition=100×(Ratio Sample −Ratio 0% Inhibition )/(Ratio 100% Inhibition −Ratio 0% Inhibition )
 
where 0.1% DMSO (0% inhibition) was the negative control and 100 μM Comparative Example 1 (100% inhibition) was used as the positive control.
 
     Example 62: High Throughput EGFR Biochemical Assay 
     EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-catalyzes the phosphorylation of a universal Tyrosine kinase peptide substrate labeled with XL665. Europium conjugated phosphor-tyrosine specific antibody binds the resulting phosphorylated peptide. Formation of phosphorylated peptide is quantified by TR-FRET with Europium as the donor and XL665 the acceptor. The assay was performed in two main steps. The first step is the kinase reaction step and the second step is the detection step with TR-FRET reagents. In brief, test compounds 1:3 serially diluted in DMSO were delivered into Corning white, low volume, non-binding 384 well plates using the Echo 550 acoustic liquid dispenser (Labcyte®). EGFR enzyme (Human EGFR, cytoplasmic domain [669-1210] from Cama Biosciences Cat. No. 08-115) and substrates TK substrate-biotin (included in Cisbio HTRF KinEASE-TK kit Cat. No. 62TK0PEJ) were dispensed into assay plates using a Multi-Flo (Bio-Tek Instruments). The standard 10 μL reaction mixture contained 6 μM ATP (1×Km) or 12 μM ATP (2×Km), 1 μM biotinylated peptide, 0.3 nM EGFR (for 1×Km ATP) or 0.1 nM EGFR (for 2×Km ATP) in reaction buffer (10 mM MOPs, pH 7.0, 1.5% Glycerol, 0.5 mg/ml BSA, 10 mM Mg-Acetate, 1 mM DTT, 0.025% NP-40). After 60 min of incubation at room temperature, 10 μL of Stop and Detect Solution (1:400 Europium Cryptate labeled anti-phosphorylated peptide antibody solution and 125 nM strepavidin-XL665 Tracer in a 50 mM Hepes pH 7.0 detection buffer containing sufficient EDTA) was added. The plate was then further incubated for over 60 minutes at room temperature and read using an Envision 2103 Multilabeled reader (PerkinElmer) with excitation/emission/FRET emission at 340 nm/615 nm/665 nm, respectively. Fluorescence intensities at 615 nm and 665 nm emission wavelengths were expressed as a ratio (665 nm/615 nm). Percent inhibition was calculated as follows:
 
% Inhibition=100×(Ratio Sample −Ratio 0% Inhibition )/(Ratio 100% Inhibition −Ratio 0% Inhibition )
 
where 0.05% DMSO (0% inhibition) was the negative control and 100 μM Staurosporine and Gefitinib (100% inhibition) was used as the positive control.
 
     As shown in Table 3, the compounds of Formula I are inhibitors of Cot (cancer Osaka thyroid). 
     
       
         
           
               
               
               
             
               
                 TABLE 3 
               
               
                   
               
               
                   
                 IC 50  HTRF 
                 EC 50  TNF 
               
               
                 Compound 
                 (nM) 
                 (nM) 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 1 
                 6 
                 143 
               
               
                 2 
                 6 
                 151 
               
               
                 3 
                 7 
                 246 
               
               
                 4 
                 6 
                 280 
               
               
                 5 
                 2 
                 153 
               
               
                 7 
                 187 
                 1517 
               
               
                 8 
                 33 
                 571 
               
               
                 9 
                 2 
                 172 
               
               
                 10 
                 4 
                 71 
               
               
                 11 
                 5 
                 98 
               
               
                 12 
                 20 
                 205 
               
               
                 13 
                 71 
                 221 
               
               
                 14 
                 13 
                 298 
               
               
                 15 
                 4 
                 134 
               
               
                 16 
                 1405 
                 &gt;10000 
               
               
                 17 
                 4 
                 260 
               
               
                 18 
                 7 
                 1219 
               
               
                 19 
                 5 
                 18017 
               
               
                 20 
                 1 
                 41 
               
               
                 21 
                 5 
                 234 
               
               
                 22 
                 2 
                 158 
               
               
                 23 
                 2 
                 95 
               
               
                 24 
                 6 
                 120 
               
               
                 25 
                 4 
                 975 
               
               
                 26 
                 13 
                 380 
               
               
                 27 
                 11 
                 232 
               
               
                 28 
                 2005 
                 &gt;1000 
               
               
                 29 
                 217 
                 &gt;1000 
               
               
                 30 
                 7213 
                 &gt;10000 
               
               
                 32 
                 5 
                 78 
               
               
                 33 
                 1625 
                 &gt;10000 
               
               
                 34 
                 13 
                 192 
               
               
                 35 
                 15 
                 229 
               
               
                 36 
                 &gt;10000 
                 &gt;10000 
               
               
                 37 
                 810 
                 &gt;1000 
               
               
                 40 
                 25 
                 1258 
               
               
                 41 
                 1 
                 74 
               
               
                 42 
                 5 
                 138 
               
               
                 43 
                 1936 
                 &gt;10000 
               
               
                 44 
                 53 
                 902 
               
               
                 45 
                 10 
                 877 
               
               
                 49 
                 26 
                 330 
               
               
                 50 
                 2 
                 54 
               
               
                 51 
                 1 
                 57 
               
               
                 52 
                 4 
                 &gt;1000 
               
               
                 53 
                 5 
                 163 
               
               
                 54 
                 2 
                 267 
               
               
                 55 
                 2 
                 414 
               
               
                 56 
                 3 
                 184 
               
               
                 57 
                 3 
                 &gt;1000 
               
               
                 58 
                 3 
                 269 
               
               
                 59 
                 1 
                 612 
               
               
                 60 
                 17 
                 &gt;1000 
               
               
                 61 
                 3 
                 75 
               
               
                 62 
                 29 
                 447 
               
               
                 63 
                 213 
                 &gt;1000 
               
               
                 64 
                 106 
                 &gt;1000 
               
               
                 65 
                 3 
                 95 
               
               
                 66 
                 5 
                 96 
               
               
                 67 
                 2 
                 41 
               
               
                 68 
                 3 
                 &gt;1000 
               
               
                 69 
                 3 
                 124 
               
               
                 70 
                 9 
                 124 
               
               
                 71 
                 4 
                 657 
               
               
                 72 
                 2 
                 66 
               
               
                 73 
                 2 
                 34 
               
               
                 74 
                 3 
                 30 
               
               
                 75 
                 199 
                 &gt;1000 
               
               
                 76 
                 2 
                 462 
               
               
                 77 
                 9 
                 108 
               
               
                 78 
                 5 
                 436 
               
               
                 79 
                 8 
                 278 
               
               
                 80 
                 31 
                 395 
               
               
                 81 
                 20 
                 316 
               
               
                 82 
                 1 
                 183 
               
               
                 83 
                 2 
                 165 
               
               
                 84 
                 2 
                 47 
               
               
                 85 
                 42 
                 862 
               
               
                 86 
                 22 
                 244 
               
               
                 87 
                 &gt;10000 
                 &gt;1000 
               
               
                 88 
                 190 
                 &gt;1000 
               
               
                 89 
                 2 
                 38 
               
               
                 90 
                 26 
                 287 
               
               
                 91 
                 16 
                 127 
               
               
                 92 
                 50 
                 495 
               
               
                 93 
                 59 
                 832 
               
               
                 94 
                 12 
                 &gt;1000 
               
               
                 95 
                 24 
                 &gt;1000 
               
               
                 96 
                 778 
                 &gt;1000 
               
               
                 97 
                 985 
                 &gt;1000 
               
               
                 98 
                 128 
                 &gt;1000 
               
               
                 99 
                 19 
                 454 
               
               
                 100 
                 16 
                 337 
               
               
                 101 
                 83 
                 &gt;1000 
               
               
                 102 
                 58 
                 &gt;1000 
               
               
                 103 
                 50 
                 522 
               
               
                 104 
                 23 
                 584 
               
               
                 105 
                 19 
                 345 
               
               
                 106 
                 58 
                 826 
               
               
                 107 
                 14 
                 272 
               
               
                 108 
                 48 
                 &gt;1000 
               
               
                 109 
                 17 
                 210 
               
               
                 110 
                 16 
                 133 
               
               
                 111 
                 72 
                 960 
               
               
                 112 
                 6 
                 125 
               
               
                 113 
                 373 
                 1609 
               
               
                 114 
                 6 
                 190 
               
               
                 115 
                 3 
                 &gt;10000 
               
               
                 116 
                 14 
                 &gt;10000 
               
               
                 117 
                 16 
                 377 
               
               
                 118 
                 11 
                 279 
               
               
                 119 
                 26 
                 166 
               
               
                 120 
                 &gt;10000 
                 1568 
               
               
                 121 
                 28 
                 469 
               
               
                 122 
                 19 
                 201 
               
               
                 123 
                 431 
                 4388 
               
               
                 124 
                 14 
                 218 
               
               
                 125 
                 1 
                 13 
               
               
                 126 
                 397 
                 &gt;10000 
               
               
                 127 
                 4 
                 86 
               
               
                 128 
                 2 
                 54 
               
               
                 129 
                 20 
                 344 
               
               
                 130 
                 23 
                 195 
               
               
                 131 
                 26 
                 435 
               
               
                 132 
                 14 
                 140 
               
               
                 133 
                 21 
                 313 
               
               
                 134 
                 6 
                 142 
               
               
                 135 
                 962 
                 7504 
               
               
                 136 
                 1 
                 20 
               
               
                 137 
                 606 
                 4374 
               
               
                 138 
                 139 
                 1358 
               
               
                 139 
                 33 
                 276 
               
               
                 140 
                 1496 
                 &gt;10000 
               
               
                 141 
                 5 
                 72 
               
               
                 142 
                 8 
                 77 
               
               
                 143 
                 99 
                 1166 
               
               
                 144 
                 3242 
                 &gt;10000 
               
               
                 145 
                 2 
                 43 
               
               
                 146 
                 95 
                 895 
               
               
                 147 
                 254 
                 3607 
               
               
                 148 
                 2139 
                 8667 
               
               
                 149 
                 162 
                 2111 
               
               
                 151 
                 &gt;10000 
                 5870 
               
               
                 152 
                 7 
                 213 
               
               
                 153 
                 196 
                 892 
               
               
                 154 
                 39 
                 576 
               
               
                 155 
                 36 
                 348 
               
               
                 156 
                 30 
                 477 
               
               
                 157 
                 3737 
                 &gt;10000 
               
               
                 158 
                 20 
                 360 
               
               
                 159 
                 114 
                 1338 
               
               
                 160 
                 496 
                 3256 
               
               
                 161 
                 941 
                 &gt;10000 
               
               
                 162 
                 7887 
                 &gt;10000 
               
               
                 163 
                 3 
                 170 
               
               
                 164 
                 1 
                 15 
               
               
                 165 
                 2087 
                 6266 
               
               
                 166 
                 61 
                 979 
               
               
                 167 
                 171 
                 &gt;10000 
               
               
                 168 
                 2065 
                 9570 
               
               
                 169 
                 543 
                 2910 
               
               
                 170 
                 48 
                 562 
               
               
                 171 
                 9533 
                 &gt;10000 
               
               
                 172 
                 139 
                 1640 
               
               
                 173 
                 140 
                 1853 
               
               
                 174 
                 837 
                 &gt;10000 
               
               
                 175 
                 280 
                 5915 
               
               
                 176 
                 83 
                 809 
               
               
                 177 
                 370 
                 2455 
               
               
                 178 
                 110 
                 674 
               
               
                 179 
                 193 
                 2306 
               
               
                 180 
                 194 
                 3590 
               
               
                 181 
                 28 
                 348 
               
               
                 182 
                 4 
                 136 
               
               
                 183 
                 89 
                 1408 
               
               
                 184 
                 154 
                 4377 
               
               
                 185 
                 11 
                 199 
               
               
                 186 
                 &gt;10000 
                 &gt;10000 
               
               
                 187 
                 85 
                 793 
               
               
                 188 
                 16 
                 203 
               
               
                 189 
                 10 
                 157 
               
               
                 190 
                 3 
                 55 
               
               
                 191 
                 56 
                 487 
               
               
                 192 
                 3 
                 107 
               
               
                 193 
                 57 
                 833 
               
               
                 194 
                 286 
                 2417 
               
               
                 195 
                 160 
                 1192 
               
               
                 196 
                 267 
                 1514 
               
               
                 197 
                 2 
                 38 
               
               
                 198 
                 12 
                 229 
               
               
                 199 
                 21 
                 395 
               
               
                 200 
                 244 
                 7584 
               
               
                 201 
                 251 
                 2542 
               
               
                 202 
                 2 
                 44 
               
               
                 203 
                 38 
                 608 
               
               
                 204 
                 97 
                 1057 
               
               
                 205 
                 38 
                 873 
               
               
                 206 
                 52 
                 547 
               
               
                 207 
                 17 
                 305 
               
               
                 208 
                 3 
                 83 
               
               
                 209 
                 3 
                 83 
               
               
                 210 
                 6 
                 243 
               
               
                 211 
                 6 
                 173 
               
               
                 212 
                 169 
                 2184 
               
               
                 213 
                 24 
                 407 
               
               
                 214 
                 151 
                 4216 
               
               
                 215 
                 119 
                 2885 
               
               
                 216 
                 492 
                 5724 
               
               
                 217 
                 327 
                 3584 
               
               
                 218 
                 432 
                 5388 
               
               
                 219 
                 534 
                 4928 
               
               
                 220 
                 296 
                 1624 
               
               
                 221 
                 244 
                 2519 
               
               
                 222 
                 8200 
                 &gt;10000 
               
               
                 223 
                 5 
                 157 
               
               
                 224 
                 28 
                 397 
               
               
                 225 
                 38 
                 800 
               
               
                 226 
                 16 
                 606 
               
               
                 227 
                 11 
                 426 
               
               
                 228 
                 807 
                 &gt;10000 
               
               
                 229 
                 2608 
                 &gt;10000 
               
               
                 230 
                 337 
                 &gt;10000 
               
               
                 231 
                 &gt;10000 
                 &gt;10000 
               
               
                 232 
                 215 
                 2435 
               
               
                 233 
                 5 
                 259 
               
               
                 234 
                 523 
                 5629 
               
               
                 235 
                 605 
                 10000 
               
               
                 236 
                 294 
                 6634 
               
               
                 237 
                 231 
                 5121 
               
               
                 238 
                 12 
                 162 
               
               
                 239 
                 2 
                 55 
               
               
                 240 
                 1 
                 71 
               
               
                 241 
                 951 
                 5084 
               
               
                 242 
                 8 
                 270 
               
               
                 243 
                 2 
                 41 
               
               
                 244 
                 576 
                 5692 
               
               
                 245 
                 46 
                 557 
               
               
                 246 
                 19 
                 490 
               
               
                 247 
                 28 
                 635 
               
               
                 248 
                 3198 
                 &gt;10000 
               
               
                 249 
                 1 
                 21 
               
               
                 250 
                 147 
                 993 
               
               
                 251 
                 105 
                 1280 
               
               
                 252 
                 5 
                 80 
               
               
                 253 
                 16 
                 214 
               
               
                 254 
                 3 
                 42 
               
               
                 255 
                 5 
                 62 
               
               
                 256 
                 3 
                 121 
               
               
                 257 
                 3 
                 93 
               
               
                 258 
                 44 
                 651 
               
               
                 259 
                 5 
                 87 
               
               
                 260 
                 33 
                 584 
               
               
                 261 
                 25 
                 504 
               
               
                 262 
                 10 
                 259 
               
               
                 263 
                 733 
                 &gt;10000 
               
               
                 264 
                 45 
                 567 
               
               
                 265 
                 12 
                 471 
               
               
                 266 
                 16 
                 424 
               
               
                 267 
                 7 
                 194 
               
               
                 268 
                 166 
                 2894 
               
               
                 269 
                 253 
                 4524 
               
               
                 270 
                 96 
                 2282 
               
               
                 271 
                 434 
                 4558 
               
               
                 272 
                 12 
                 215 
               
               
                 273 
                 13 
                 178 
               
               
                 274 
                 5 
                 254 
               
               
                 275 
                 23 
                 246 
               
               
                 276 
                 3 
                 166 
               
               
                 277 
                 32 
                 858 
               
               
                 278 
                 222 
                 &gt;10000 
               
               
                 279 
                 3046 
                 8201 
               
               
                 280 
                 228 
                 1472 
               
               
                 281 
                 68 
                 1044 
               
               
                 282 
                 39 
                 525 
               
               
                 283 
                 90 
                 764 
               
               
                 284 
                 4 
                 52 
               
               
                 285 
                 3 
                 45 
               
               
                 286 
                 7 
                 127 
               
               
                 287 
                 10 
                 140 
               
               
                 288 
                 6 
                 130 
               
               
                 289 
                 4 
                 116 
               
               
                 290 
                 8 
                 117 
               
               
                 291 
                 8 
                 173 
               
               
                 292 
                 13 
                 237 
               
               
                 293 
                 24 
                 469 
               
               
                 294 
                 92 
                 1877 
               
               
                 295 
                 389 
                 &gt;10000 
               
               
                 296 
                 2 
                 44 
               
               
                 297 
                 &gt;10000 
                 4250 
               
               
                 298 
                 121 
                 1468 
               
               
                 299 
                 12 
                 309 
               
               
                 300 
                 4 
                 126 
               
               
                 301 
                 &gt;10000 
                 1242 
               
               
                 302 
                 3 
                 74 
               
               
                 303 
                 4 
                 174 
               
               
                 304 
                 864 
                 &gt;10000 
               
               
                 305 
                 4 
                 78 
               
               
                 306 
                 52 
                 536 
               
               
                 307 
                 116 
                 950 
               
               
                 308 
                 26 
                 361 
               
               
                 309 
                 476 
                 4156 
               
               
                 310 
                 &gt;10000 
                 2355 
               
               
                 311 
                 5 
                 158 
               
               
                 312 
                 5 
                 177 
               
               
                 313 
                 39 
                 527 
               
               
                 314 
                 1328 
                 6386 
               
               
                 315 
                 134 
                 1012 
               
               
                 316 
                 1822 
                 3641 
               
               
                 317 
                 1000 
                 8260 
               
               
                 318 
                 34 
                 451 
               
               
                 319 
                 372 
                 4476 
               
               
                 320 
                 1151 
                 6432 
               
               
                 321 
                 159 
                 391 
               
               
                 322 
                 140 
                 959 
               
               
                 323 
                 82 
                 1605 
               
               
                 324 
                 4 
                 450 
               
               
                 325 
                 8 
                 356 
               
               
                 326 
                 199 
                 1965 
               
               
                 327 
                 4 
                 166 
               
               
                 328 
                 24 
                 1241 
               
               
                 329 
                 32 
                 808 
               
               
                 330 
                 1419 
                 &gt;10000 
               
               
                 331 
                 4 
                 75 
               
               
                 332 
                 25 
                 426 
               
               
                 333 
                 9 
                 260 
               
               
                 334 
                 258 
                 &gt;10000 
               
               
                 335 
                 40 
                 204 
               
               
                 336 
                 71 
                 619 
               
               
                 337 
                 49 
                 674 
               
               
                 338 
                 8 
                 183 
               
               
                 339 
                 55 
                 1167 
               
               
                 340 
                 2 
                 57 
               
               
                 341 
                 1 
                 71 
               
               
                 342 
                 64 
                 1227 
               
               
                 343 
                 13 
                 151 
               
               
                 344 
                 89 
                 2225 
               
               
                 345 
                 57 
                 976 
               
               
                 346 
                 338 
                 6097 
               
               
                 347 
                 24 
                 773 
               
               
                 348 
                 44 
                 1197 
               
               
                 349 
                 131 
                 687 
               
               
                 350 
                 9 
                 387 
               
               
                 351 
                 6 
                 206 
               
               
                 352 
                 21 
                 1293 
               
               
                 353 
                 104 
                 3177 
               
               
                 354 
                 86 
                 689 
               
               
                 355 
                 121 
                 4660 
               
               
                 356 
                 550 
                 6664 
               
               
                 357 
                 20 
                 522 
               
               
                 358 
                 12 
                 673 
               
               
                 359 
                 53 
                 2256 
               
               
                 360 
                 21 
                 423 
               
               
                 361 
                 35 
                 653 
               
               
                 362 
                 5 
                 83 
               
               
                 363 
                 874 
                 &gt;10000 
               
               
                 364 
                 48 
                 631 
               
               
                 365 
                 868 
                 9333 
               
               
                 366 
                 110 
                 1302 
               
               
                 367 
                 297 
                 3849 
               
               
                 368 
                 50 
                 1128 
               
               
                 369 
                 4 
                 93 
               
               
                 370 
                 5 
                 417 
               
               
                 371 
                 154 
                 877 
               
               
                 372 
                 11 
                 771 
               
               
                 373 
                 3011 
                 7515 
               
               
                 374 
                 161 
                 3838 
               
               
                 375 
                 48 
                 1256 
               
               
                 376 
                 47 
                 1608 
               
               
                 377 
                 495 
                 &gt;10000 
               
               
                 378 
                 &gt;10000 
                 &gt;10000 
               
               
                 379 
                 30 
                 191 
               
               
                 380 
                 78 
                 1285 
               
               
                 381 
                 44 
                 644 
               
               
                 382 
                 8 
                 323 
               
               
                 383 
                 11 
                 148 
               
               
                 384 
                 8 
                 832 
               
               
                 385 
                 4 
                 692 
               
               
                 386 
                 5 
                 1441 
               
               
                 387 
                 50 
                 809 
               
               
                 388 
                 83 
                 1258 
               
               
                 389 
                 37 
                 817 
               
               
                 390 
                 30 
                 318 
               
               
                 391 
                 17 
                 214 
               
               
                 392 
                 35 
                 308 
               
               
                 393 
                 179 
                 333 
               
               
                 394 
                 36 
                 160 
               
               
                 395 
                 47 
                 273 
               
               
                 396 
                 25 
                 1234 
               
               
                 397 
                 125 
                 726 
               
               
                 398 
                 28 
                 1050 
               
               
                 399 
                 38 
                 891 
               
               
                 400 
                 47 
                 1232 
               
               
                 401 
                 758 
                 4794 
               
               
                 402 
                 353 
                 3651 
               
               
                 403 
                 15 
                 532 
               
               
                 404 
                 34 
                 570 
               
               
                 405 
                 69 
                 2305 
               
               
                 406 
                 212 
                 4432 
               
               
                 407 
                 47 
                 1529 
               
               
                 408 
                 41 
                 779 
               
               
                 409 
                 23 
                 776 
               
               
                 410 
                 30 
                 723 
               
               
                 411 
                 111 
                 3406 
               
               
                 412 
                 50 
                 2225 
               
               
                 413 
                 93 
                 2746 
               
               
                 414 
                 4 
                 140 
               
               
                 415 
                 9 
                 409 
               
               
                 416 
                 6 
                 209 
               
               
                 417 
                 74 
                 1929 
               
               
                 418 
                 361 
                 4172 
               
               
                 419 
                 392 
                 4305 
               
               
                 420 
                 191 
                 5158 
               
               
                 421 
                 1492 
                 &gt;10000 
               
               
                 422 
                 48 
                 1346 
               
               
                 423 
                 17 
                 1256 
               
               
                 424 
                 6 
                 415 
               
               
                 425 
                 10 
                 438 
               
               
                 426 
                 3154 
                 &gt;10000 
               
               
                 427 
                 316 
                 8879 
               
               
                 428 
                 87 
                 1830 
               
               
                 429 
                 9 
                 257 
               
               
                 430 
                 7 
                 679 
               
               
                 431 
                 96 
                 3279 
               
               
                 432 
                 624 
                 3926 
               
               
                 433 
                 31 
                 1379 
               
               
                 434 
                 2761 
                 2382 
               
               
                 435 
                 7927 
                 &gt;10000 
               
               
                 436 
                 1363 
                 3034 
               
               
                 437 
                 448 
                 3911 
               
               
                 438 
                 135 
                 5130 
               
               
                 439 
                 2963 
                 &gt;10000 
               
               
                 440 
                 46 
                 371 
               
               
                 441 
                 804 
                 5824 
               
               
                 442 
                 193 
                 4898 
               
               
                 443 
                 2698 
                 &gt;10000 
               
               
                 444 
                 28 
                 855 
               
               
                 445 
                 46 
                 1273 
               
               
                 446 
                 11 
                 338 
               
               
                 447 
                 23 
                 1930 
               
               
                 448 
                 26 
                 1860 
               
               
                 449 
                 161 
                 830 
               
               
                 450 
                 3 
                 305 
               
               
                 451 
                 68 
                 266 
               
               
                 452 
                 98 
                 420 
               
               
                 453 
                 11 
                 231 
               
               
                 454 
                 49 
                 1773 
               
               
                 455 
                 48 
                 171 
               
               
                 456 
                 7 
                 305 
               
               
                 457 
                 43 
                 616 
               
               
                 458 
                 17 
                 598 
               
               
                 459 
                 9 
                 454 
               
               
                 460 
                 23 
                 1256 
               
               
                 461 
                 20 
                 1532 
               
               
                 462 
                 17 
                 787 
               
               
                 463 
                 144 
                 1412 
               
               
                 464 
                 61 
                 694 
               
               
                 465 
                 41 
                 821 
               
               
                 466 
                 53 
                 1397 
               
               
                 467 
                 13 
                 978 
               
               
                 468 
                 173 
                 3146 
               
               
                 469 
                 14 
                 315 
               
               
                 470 
                 13 
                 608 
               
               
                 471 
                 333 
                 8642 
               
               
                 472 
                 96 
                 2356 
               
               
                 473 
                 59 
                 784 
               
               
                 474 
                 68 
                 1567 
               
               
                 475 
                 459 
                 &gt;10000 
               
               
                 476 
                 1738 
                 &gt;10000 
               
               
                 477 
                 243 
                 6652 
               
               
                 478 
                 1051 
                 5530 
               
               
                 479 
                 5276 
                 &gt;10000 
               
               
                 480 
                 1223 
                 8513 
               
               
                 481 
                 298 
                 8800 
               
               
                 482 
                 332 
                 &gt;10000 
               
               
                 483 
                 387 
                 &gt;10000 
               
               
                 484 
                 371 
                 &gt;10000 
               
               
                 485 
                 306 
                 7243 
               
               
                 486 
                 24 
                 637 
               
               
                 487 
                 2253 
                 6783 
               
               
                 488 
                 1305 
                 9013 
               
               
                 489 
                 10 
                 184 
               
               
                 490 
                 172 
                 3186 
               
               
                 491 
                 123 
                 3837 
               
               
                 492 
                 65 
                 966 
               
               
                 493 
                 18 
                 1215 
               
               
                 494 
                 47 
                 585 
               
               
                 495 
                 32 
                 641 
               
               
                 496 
                 4 
                 1836 
               
               
                 497 
                 26 
                 985 
               
               
                 498 
                 8 
                 520 
               
               
                 499 
                 6 
                 985 
               
               
                 500 
                 92 
                 2155 
               
               
                 501 
                 94 
                 2136 
               
               
                 502 
                 160 
                 1952 
               
               
                 503 
                 98 
                 1690 
               
               
                 504 
                 1780 
                 8508 
               
               
                 505 
                 240 
                 2620 
               
               
                 506 
                 1687 
                 5286 
               
               
                 507 
                 741 
                 8513 
               
               
                 508 
                 5347 
                 &gt;10000 
               
               
                 509 
                 206 
                 2990 
               
               
                 510 
                 5 
                 321 
               
               
                 511 
                 17 
                 701 
               
               
                 512 
                 85 
                 1103 
               
               
                 513 
                 22 
                 1335 
               
               
                 514 
                 2 
                 62 
               
               
                 515 
                 1 
                 324 
               
               
                 516 
                 4 
                 92 
               
               
                 517 
                 10 
                 255 
               
               
                 518 
                 52 
                 570 
               
               
                 519 
                 301 
                 3149 
               
               
                 520 
                 &gt;10000 
                 &gt;10000 
               
               
                 521 
                 41 
                 934 
               
               
                 522 
                 786 
                 9719 
               
               
                 523 
                 300 
                 4882 
               
               
                 524 
                 787 
                 &gt;10000 
               
               
                 525 
                 726 
                 4257 
               
               
                 526 
                 24 
                 503 
               
               
                 527 
                 52 
                 1365 
               
               
                 528 
                 54 
                 830 
               
               
                 529 
                 2 
                 71 
               
               
                 530 
                 198 
                 &gt;10000 
               
               
                 531 
                 16 
                 491 
               
               
                 532 
                 &gt;10000 
                 &gt;10000 
               
               
                 533 
                 73 
                 660 
               
               
                 534 
                 57 
                 3147 
               
               
                 535 
                 4 
                 500 
               
               
                 536 
                 3 
                 84 
               
               
                 537 
                 17 
                 458 
               
               
                 538 
                 3 
                 58 
               
               
                 539 
                 337 
                 3069 
               
               
                 540 
                 404 
                 5148 
               
               
                 541 
                 7306 
                 &gt;10000 
               
               
                 542 
                 &gt;10000 
                 &gt;10000 
               
               
                 543 
                 7 
                 51 
               
               
                 544 
                 94 
                 1190 
               
               
                 545 
                 3 
                 88 
               
               
                 546 
                 8 
                 200 
               
               
                 547 
                 2 
                 508 
               
               
                 548 
                 1 
                 40 
               
               
                 549 
                 3 
                 650 
               
               
                 550 
                 1 
                 115 
               
               
                 551 
                 5 
                 475 
               
               
                 552 
                 5 
                 135 
               
               
                 553 
                 10 
                 423 
               
               
                 554 
                 1301 
                 8250 
               
               
                 555 
                 183 
                 537 
               
               
                 556 
                 725 
                 &gt;10000 
               
               
                 557 
                 999 
                 &gt;10000 
               
               
                 558 
                 11 
                 199 
               
               
                 559 
                 14 
                 6046 
               
               
                 560 
                 3 
                 8831 
               
               
                 561 
                 6 
                 1153 
               
               
                 562 
                 4 
                 848 
               
               
                 563 
                 2 
                 280 
               
               
                 564 
                 1 
                 68 
               
               
                 565 
                 24 
                 &gt;10000 
               
               
                 566 
                 5 
                 353 
               
               
                 567 
                 3 
                 76 
               
               
                 568 
                 2 
                 143 
               
               
                 569 
                 7 
                 721 
               
               
                 570 
                 13 
                 207 
               
               
                 571 
                 6 
                 382 
               
               
                 572 
                 2 
                 111 
               
               
                 573 
                 10 
                 462 
               
               
                 574 
                 42 
                 161 
               
               
                 575 
                 10 
                 429 
               
               
                 576 
                 2 
                 72 
               
               
                 577 
                 3 
                 38 
               
               
                 578 
                 13 
                 2150 
               
               
                 579 
                 8 
                 713 
               
               
                 580 
                 287 
                 1593 
               
               
                 581 
                 333 
                 4220 
               
               
                 582 
                 25 
                 734 
               
               
                 583 
                 1001 
                 4359 
               
               
                 584 
                 10 
                 403 
               
               
                 585 
                 16 
                 427 
               
               
                 586 
                 892 
                 8557 
               
               
                 587 
                 144 
                 3897 
               
               
                 588 
                 17 
                 1020 
               
               
                 589 
                 480 
                 8440 
               
               
                 590 
                 131 
                 3515 
               
               
                 591 
                 27 
                 713 
               
               
                 592 
                 7 
                 352 
               
               
                 593 
                 1 
                 147 
               
               
                 594 
                 1 
                 1716 
               
               
                 595 
                 8 
                 305 
               
               
                 596 
                 33 
                 3049 
               
               
                 597 
                 189 
                 3177 
               
               
                 598 
                 4 
                 418 
               
               
                 599 
                 3 
                 134 
               
               
                 600 
                 2 
                 78 
               
               
                 601 
                 64 
                 2063 
               
               
                 602 
                 77 
                 3053 
               
               
                 603 
                 61 
                 561 
               
               
                 604 
                 156 
                 3038 
               
               
                 605 
                 41 
                 375 
               
               
                 606 
                 2 
                 348 
               
               
                 607 
                 2 
                 198 
               
               
                 608 
                 1 
                 41 
               
               
                 609 
                 7 
                 384 
               
               
                 610 
                 14 
                 337 
               
               
                 611 
                 51 
                 369 
               
               
                 612 
                 84 
                 2015 
               
               
                 613 
                 41 
                 708 
               
               
                 614 
                 123 
                 1113 
               
               
                 615 
                 141 
                 719 
               
               
                 616 
                 40 
                 2182 
               
               
                 617 
                 43 
                 12252 
               
               
                 618 
                 53 
                 1700 
               
               
                 619 
                 16 
                 826 
               
               
                 620 
                 6 
                 96 
               
               
                 621 
                 2 
                 112 
               
               
                 622 
                 5 
                 851 
               
               
                 623 
                 1 
                 90 
               
               
                 624 
                 3 
                 266 
               
               
                 625 
                 116 
                 1161 
               
               
                 626 
                 784 
                 &gt;50000 
               
               
                 627 
                 16 
                 456 
               
               
                 628 
                 7 
                 109 
               
               
                 629 
                 3 
                 72 
               
               
                 630 
                 3 
                 1634 
               
               
                 631 
                 166 
                 1083 
               
               
                 632 
                 3 
                 163 
               
               
                 633 
                 10 
                 1576 
               
               
                 634 
                 30 
                 3088 
               
               
                 635 
                 13 
                 1084 
               
               
                 636 
                 143 
                 2391 
               
               
                 637 
                 36 
                 1277 
               
               
                 638 
                 &gt;10000 
                 2647 
               
               
                 639 
                 664 
                 1713 
               
               
                 640 
                 2335 
                 2841 
               
               
                 641 
                 35 
                 1531 
               
               
                 642 
                 17 
                 383 
               
               
                 643 
                 7 
                 151 
               
               
                 644 
                 132 
                 1098 
               
               
                 645 
                 2 
                 41 
               
               
                 646 
                 1 
                 49 
               
               
                 647 
                 377 
                 3240 
               
               
                 648 
                 &gt;10000 
                 4430 
               
               
                 649 
                 1462 
                 2744 
               
               
                 650 
                 32 
                 661 
               
               
                 651 
                 52 
                 10609 
               
               
                 652 
                 61 
                 7656 
               
               
                 653 
                 160 
                 9285 
               
               
                 654 
                 2040 
                 &gt;50000 
               
               
                 655 
                 324 
                 10497 
               
               
                 656 
                 39 
                 1824 
               
               
                 657 
                 143 
                 2494 
               
               
                 658 
                 27 
                 12197 
               
               
                 659 
                 95 
                 5354 
               
               
                 660 
                 14 
                 807 
               
               
                 661 
                 25 
                 1087 
               
               
                 662 
                 70 
                 1270 
               
               
                 663 
                 72 
                 4738 
               
               
                 664 
                 379 
                 8153 
               
               
                 665 
                 25 
                 1971 
               
               
                 666 
                 14 
                 458 
               
               
                 667 
                 28 
                 887 
               
               
                 668 
                 97 
                 1610 
               
               
                 669 
                 39 
                 1093 
               
               
                 671 
                 10 
                 682 
               
               
                 672 
                 32 
                 889 
               
               
                 673 
                 2 
                 1547 
               
               
                 674 
                 3 
                 318 
               
               
                 675 
                 1 
                 81 
               
               
                 676 
                 6 
                 434 
               
               
                 677 
                 10 
                 809 
               
               
                 678 
                 1432 
                 5686 
               
               
                 679 
                 355 
                 12454 
               
               
                 680 
                 44 
                 6752 
               
               
                 681 
                 434 
                 12822 
               
               
                 682 
                 599 
                 15714 
               
               
                 683 
                 165 
                 7249 
               
               
                 684 
                 7351 
                 6041 
               
               
                 685 
                 16 
                 359 
               
               
                 686 
                 7243 
                 5898 
               
               
                 687 
                 40 
                 2832 
               
               
                 688 
                 621 
                 1252 
               
               
                 689 
                 11 
                 343 
               
               
                 690 
                 2 
                 317 
               
               
                 691 
                 2 
                 90 
               
               
                 692 
                 51 
                 797 
               
               
                 693 
                 46 
                 1543 
               
               
                 694 
                 20 
                 843 
               
               
                 695 
                 19 
                 434 
               
               
                 696 
                 85 
                 3288 
               
               
                 697 
                 &gt;10000 
                 17149 
               
               
                 698 
                 317 
                 16083 
               
               
                 699 
                 379 
                 10554 
               
               
                 700 
                 444 
                 2236 
               
               
                 701 
                 48 
                 795 
               
               
                 702 
                 314 
                 17597 
               
               
                 703 
                 95 
                 11965 
               
               
                 704 
                 37 
                 3513 
               
               
                 705 
                 2825 
                 12188 
               
               
                 706 
                 95 
                 12761 
               
               
                 707 
                 134 
                 3012 
               
               
                 708 
                 103 
                 533 
               
               
                 709 
                 18 
                 307 
               
               
                 710 
                 20 
                 352 
               
               
                 711 
                 46 
                 &gt;10000 
               
               
                 712 
                 14 
                 498 
               
               
                 713 
                 17 
                 358 
               
               
                 714 
                 131 
                 1696 
               
               
                 715 
                 62 
                 2076 
               
               
                 716 
                 60 
                 847 
               
               
                 719 
                 41 
                 2585 
               
               
                 720 
                 72 
                 3990 
               
               
                 721 
                 21 
                 470 
               
               
                 722 
                 4 
                 76 
               
               
                 723 
                 217 
                 1295 
               
               
                 724 
                 87 
                 1402 
               
               
                 727 
                 3 
                 178 
               
               
                 728 
                 3 
                 124 
               
               
                 729 
                 32 
                 532 
               
               
                 731 
                 78 
                 4451 
               
               
                 733 
                 6 
                 884 
               
               
                 734 
                 151 
                 3897 
               
               
                 736 
                 41 
                 376 
               
               
                 737 
                 21 
                 411 
               
               
                 738 
                 7 
                 274 
               
               
                 739 
                 22 
                 1097 
               
               
                 740 
                 244 
                 5547 
               
               
                 741 
                 122 
                 1243 
               
               
                 742 
                 315 
                 1773 
               
               
                 743 
                 29 
                 575 
               
               
                 744 
                 13 
                 363 
               
               
                 745 
                 70 
                 615 
               
               
                 746 
                 29 
                 349 
               
               
                 747 
                 4 
                 110 
               
               
                 748 
                 60 
                 610 
               
               
                 750 
                 1894 
                 4721 
               
               
                 753 
                 88 
                 1677 
               
               
                 755 
                 201 
                 3195 
               
               
                 756 
                 108 
                 2985 
               
               
                 757 
                 41 
                 738 
               
               
                 758 
                 97 
                 1312 
               
               
                 759 
                 2140 
                 2749 
               
               
                 764 
                 38 
                 3270 
               
               
                 765 
                 70 
                 1290 
               
               
                 766 
                 41 
                 1769 
               
               
                 767 
                 48 
                 1270 
               
               
                 768 
                 83 
                 2504 
               
               
                 774 
                 3 
                 127 
               
               
                 776 
                 25 
                 1242 
               
               
                 777 
                 72 
                 6968 
               
               
                 778 
                 2 
                 305 
               
               
                 779 
                 4 
                 196 
               
               
                 780 
                 20 
                 865 
               
               
                 781 
                 11 
                 597 
               
               
                 784 
                 249 
                 1986 
               
               
                 786 
                 173 
                 6626 
               
               
                 787 
                 11 
                 362 
               
               
                 790 
                 4 
                 305 
               
               
                 791 
                 3 
                 50 
               
               
                 792 
                 5 
                 91 
               
               
                 793 
                 7 
                 209 
               
               
                 794 
                 4 
                 441 
               
               
                 795 
                 13 
                 314 
               
               
                 796 
                 2 
                 200 
               
               
                 797 
                 3 
                 107 
               
               
                 802 
                 78 
                 963 
               
               
                 803 
                 7 
                 206 
               
               
                 805 
                 588 
                 &gt;1000 
               
               
                 806 
                 850 
                 &gt;50000 
               
               
                 808 
                 26 
                 434 
               
               
                 813 
                 6 
                 116 
               
               
                 814 
                 10 
                 704 
               
               
                 815 
                 25 
                 311 
               
               
                 819 
                 22 
                 426 
               
               
                 824 
                 58 
                 450 
               
               
                 825 
                 4 
                 150 
               
               
                 828 
                 297 
                 1154 
               
               
                 831 
                 10 
                 381 
               
               
                 836 
                 8 
                 241 
               
               
                 841 
                 8 
                 141 
               
               
                 842 
                 998 
                 22096 
               
               
                 847 
                 366 
                 7862 
               
               
                 849 
                 687 
                 6276 
               
               
                 853 
                 6301 
                 &gt;1000 
               
               
                 854 
                 469 
                 &gt;10000 
               
               
                 858 
                 8 
                 99 
               
               
                 859 
                 12 
                 533 
               
               
                 869 
                 125 
                 2757 
               
               
                 872 
                 41 
                 1306 
               
               
                 881 
                 39 
                 673 
               
               
                 882 
                 20 
                 321 
               
               
                 884 
                 11 
                 466 
               
               
                 885 
                 9 
                 287 
               
               
                 887 
                 70 
                 1894 
               
               
                 889 
                 32 
                 362 
               
               
                 894 
                 168 
                 1747 
               
               
                 895 
                 56 
                 1003 
               
               
                 907 
                 5 
                 128 
               
               
                 918 
                 194 
                 8578 
               
               
                 919 
                 2 
                 62 
               
               
                 920 
                 10 
                 215 
               
               
                 6 
                 13 
               
               
                 31 
                 19 
               
               
                 38 
                 2 
               
               
                 39 
                 1992 
               
               
                 717 
                 1580 
               
               
                 718 
                 3465 
               
               
                 725 
                 338 
               
               
                 726 
                 39 
               
               
                 730 
                 12 
               
               
                 732 
                 30 
               
               
                 735 
                 105 
               
               
                 749 
                 3212 
               
               
                 751 
                 &gt;10000 
               
               
                 752 
                 &gt;10000 
               
               
                 754 
                 2534 
               
               
                 760 
                 2337 
               
               
                 761 
                 484 
               
               
                 762 
                 513 
               
               
                 763 
                 23 
               
               
                 769 
                 &gt;10000 
               
               
                 770 
                 60 
               
               
                 771 
                 93 
               
               
                 772 
                 324 
               
               
                 773 
                 1861 
               
               
                 775 
                 5 
               
               
                 782 
                 444 
               
               
                 783 
                 291 
               
               
                 785 
                 782 
               
               
                 788 
                 1009 
               
               
                 789 
                 657 
               
               
                 798 
                 7915 
               
               
                 799 
                 1479 
               
               
                 800 
                 &gt;10000 
               
               
                 801 
                 1066 
               
               
                 807 
                 437 
               
               
                 810 
                 12 
               
               
                 811 
                 34 
               
               
                 812 
                 794 
               
               
                 817 
                 7 
               
               
                 818 
                 447 
               
               
                 820 
                 23 
               
               
                 821 
                 21 
               
               
                 822 
                 90 
               
               
                 823 
                 97 
               
               
                 826 
                 6 
               
               
                 827 
                 34 
               
               
                 829 
                 6 
               
               
                 830 
                 363 
               
               
                 832 
                 9 
               
               
                 833 
                 7 
               
               
                 834 
                 756 
               
               
                 838 
                 32 
               
               
                 839 
                 24 
               
               
                 840 
                 84 
               
               
                 843 
                 58 
               
               
                 844 
                 48 
               
               
                 845 
                 99 
               
               
                 846 
                 &gt;10000 
               
               
                 850 
                 926 
               
               
                 851 
                 7 
               
               
                 852 
                 22 
               
               
                 855 
                 2396 
               
               
                 856 
                 860 
               
               
                 857 
                 1343 
               
               
                 862 
                 3962 
               
               
                 863 
                 364 
               
               
                 864 
                 22 
               
               
                 865 
                 46 
               
               
                 866 
                 2098 
               
               
                 867 
                 46 
               
               
                 868 
                 119 
               
               
                 870 
                 27 
               
               
                 871 
                 90 
               
               
                 873 
                 21 
               
               
                 874 
                 97 
               
               
                 875 
                 66 
               
               
                 876 
                 385 
               
               
                 877 
                 47 
               
               
                 878 
                 7695 
               
               
                 879 
                 101 
               
               
                 880 
                 68 
               
               
                 883 
                 6684 
               
               
                 886 
                 11 
               
               
                 888 
                 50 
               
               
                 890 
                 &gt;10000 
               
               
                 891 
                 30 
               
               
                 892 
                 78 
               
               
                 893 
                 39 
               
               
                 896 
                 &gt;10000 
               
               
                 897 
                 59 
               
               
                 898 
                 40 
               
               
                 899 
                 &gt;1000 
               
               
                 900 
                 14 
               
               
                 901 
                 11 
               
               
                 902 
                 &gt;1000 
               
               
                 903 
                 7 
               
               
                 904 
                 5 
               
               
                 905 
                 &gt;1000 
               
               
                 906 
                 8 
               
               
                 908 
                 5 
               
               
                 909 
                 &gt;1000 
               
               
                 910 
                 52 
               
               
                 911 
                 36 
               
               
                 912 
                 60 
               
               
                 913 
                 &gt;1000 
               
               
                 914 
                 23 
               
               
                 915 
                 &gt;1000 
               
               
                 916 
                 48 
               
               
                 917 
                 23 
               
               
                 921 
                 8 
               
               
                 922 
                 4 
               
               
                 925 
                 10 
                 187 
               
               
                 926 
                 7 
                 346 
               
               
                 927 
                 34 
                 576 
               
               
                 928 
                 68 
                 443 
               
               
                 929 
                 7 
                 98 
               
               
                 930 
                 5 
                 66 
               
               
                 931 
                 27 
                 447 
               
               
                 932 
                 25 
                 505 
               
               
                 933 
                 314 
                 1000 
               
               
                 934 
                 371 
                 1000 
               
               
                 935 
                 10000 
                 1000 
               
               
                 936 
                 12 
                 222 
               
               
                 937 
                 3 
                 35 
               
               
                 938 
                 6 
                 71 
               
               
                 939 
                 4 
                 92 
               
               
                 940 
                 4 
                 144 
               
               
                 941 
                 1 
                 52 
               
               
                 942 
                 1 
                 141 
               
               
                 943 
                 4 
                 93 
               
               
                 944 
                 1 
                 51 
               
               
                 945 
                 2 
                 29 
               
               
                 946 
                 745 
                 1000 
               
               
                 947 
                 14 
                 282 
               
               
                 948 
                 1 
                 78 
               
               
                 949 
                 1 
                 19 
               
               
                 950 
                 10000 
                 1000 
               
               
                 951 
                 10000 
                 1000 
               
               
                 952 
                 8 
                 134 
               
               
                 953 
                 111 
                 1000 
               
               
                 954 
                 5 
                 130 
               
               
                 955 
                 2 
                 31 
               
               
                 956 
                 5 
                 61 
               
               
                 957 
                 3 
                 170 
               
               
                 958 
                 31 
                 460 
               
               
                 959 
                 25 
                 84 
               
               
                 960 
                 12 
                 86 
               
               
                 961 
                 1 
                 21 
               
               
                 962 
                 7 
                 116 
               
               
                 963 
                 3 
                 777 
               
               
                 964 
                 12 
                 254 
               
               
                 965 
                 14 
                 286 
               
               
                 966 
                 86 
                 1000 
               
               
                 967 
                 714 
                 1000 
               
               
                 968 
                 17 
                 110 
               
               
                 969 
                 1 
                 1000 
               
               
                 970 
                 8 
                 202 
               
               
                 971 
                 4 
                 270 
               
               
                 972 
                 27 
                 636 
               
               
                 973 
                 9 
                 67 
               
               
                 974 
                 46 
                 46 
               
               
                 975 
                 3 
                 321 
               
               
                 976 
                 6 
                 58 
               
               
                 977 
                 6 
                 285 
               
               
                 978 
                 5 
                 65 
               
               
                 979 
                 4 
                 103 
               
               
                 980 
                 80 
                 1000 
               
               
                 981 
                 22 
                 318 
               
               
                 982 
                 23 
                 540 
               
               
                 983 
                 11 
                 39 
               
               
                 984 
                 125 
                 93 
               
               
                 985 
                 4 
                 119 
               
               
                 986 
                 13 
                 222 
               
               
                 987 
                 32 
                 69 
               
               
                 988 
                 14 
                 334 
               
               
                 989 
                 12 
                 111 
               
               
                 990 
                 12 
                 76 
               
               
                 991 
                 34 
                 136 
               
               
                 992 
                 5 
                 76 
               
               
                 993 
                 32 
                 3612 
               
               
                 994 
                 33 
                 103 
               
               
                 995 
                 3 
                 49 
               
               
                 996 
                 6 
                 109 
               
               
                 997 
                 48 
                 61 
               
               
                 998 
                 53 
                 250 
               
               
                 999 
                 63 
                 306 
               
               
                 1000 
                 58 
                 177 
               
               
                 1001 
                 22 
                 344 
               
               
                 1002 
                 14 
                 202 
               
               
                 1003 
                 19 
                 227 
               
               
                 1004 
                 33 
                 1000 
               
               
                 1005 
                 10000 
                 1000 
               
               
                 1006 
                 9 
                 72 
               
               
                 1007 
                 2 
                 66 
               
               
                 1008 
                 1 
                 123 
               
               
                 1009 
                 1 
                 67 
               
               
                 1010 
                 69 
                 928 
               
               
                 1011 
                 3 
                 22 
               
               
                 1012 
                 3 
                 36 
               
               
                 1013 
                 2 
                 23 
               
               
                 1014 
                 3 
                 106 
               
               
                 1015 
                 14 
                 462 
               
               
                 1016 
                 28 
                 1000 
               
               
                 1017 
                 85 
                 1000 
               
               
                 1018 
                 22 
                 326 
               
               
                 1020 
                 6 
                 161 
               
               
                 1021 
                 4 
                 234 
               
               
                 1022 
                 7 
                 503 
               
               
                 1023 
                 21 
                 1000 
               
               
                 1024 
                 5 
                 54 
               
               
                 1025 
                 10 
                 131 
               
               
                 1026 
                 7 
                 371 
               
               
                 1027 
                 4 
                 141 
               
               
                 1028 
                 17 
                 259 
               
               
                 1029 
                 14 
                 225 
               
               
                 1030 
                 5 
                 82 
               
               
                 1031 
                 1 
                 118 
               
               
                 1032 
                 1 
                 161 
               
               
                 1033 
                 2 
                 456 
               
               
                 1034 
                 4 
                 93 
               
               
                 1035 
                 19 
                 316 
               
               
                 1036 
                 9 
                 195 
               
               
                 1037 
                 102 
                 1000 
               
               
                 1038 
                 10 
                 566 
               
               
                 1039 
                 19 
                 496 
               
               
                 1040 
                 4 
                 87 
               
               
                 1041 
                 4 
                 86 
               
               
                 1042 
                 2 
                 105 
               
               
                 1043 
                 3 
                 110 
               
               
                 1044 
                 8 
                 214 
               
               
                 1045 
                 5 
                 268 
               
               
                 1046 
                 142 
                 1000 
               
               
                 1047 
                 101 
                 1000 
               
               
                 1048 
                 33 
                 637 
               
               
                 1049 
                 2 
                 35 
               
               
                 1050 
                 7 
                 202 
               
               
                 1051 
                 4 
                 163 
               
               
                 1052 
                 189 
                 1000 
               
               
                 1053 
                 26 
                 200 
               
               
                 1054 
                 1 
                 81 
               
               
                 1055 
                 3 
                 100 
               
               
                 1056 
                 2 
                 63 
               
               
                 1057 
                 4 
                 73 
               
               
                 1058 
                 35 
                 314 
               
               
                 1059 
                 75 
                 553 
               
               
                 1060 
                 33 
                 311 
               
               
                 1061 
                 85 
                 620 
               
               
                 1062 
                 3 
                 70 
               
               
                 1063 
                 6 
                 73 
               
               
                 1064 
                 12 
                 103 
               
               
                 1065 
                 22 
                 237 
               
               
                 1066 
                 10 
                 85 
               
               
                 1067 
                 17 
                 213 
               
               
                 1068 
                 3 
                 58 
               
               
                 1069 
                 2 
                 54 
               
               
                 1070 
                 2 
                 272 
               
               
                 1071 
                 3 
                 215 
               
               
                 1072 
                 3 
                 1000 
               
               
                 1073 
                 1 
                 1000 
               
               
                 1074 
                 48 
                 435 
               
               
                 1075 
                 23 
                 185 
               
               
                 1076 
                 37 
                 182 
               
               
                 1077 
                 2 
                 77 
               
               
                 1078 
                 12 
                 175 
               
               
                 1079 
                 19 
                 220 
               
               
                 1080 
                 7 
                 148 
               
               
                 1081 
                 3 
                 219 
               
               
                 1082 
                 2 
                 262 
               
               
                 1083 
                 13 
                 63 
               
               
                 1084 
                 7 
                 73 
               
               
                 1085 
                 5 
                 205 
               
               
                 1086 
                 4 
                 76 
               
               
                 1087 
                 22 
                 375 
               
               
                 1088 
                 22 
                 934 
               
               
                 1089 
                 7 
                 23 
               
               
                 1090 
                 75 
                 614 
               
               
                 1091 
                 28 
                 1000 
               
               
                 1092 
                 20 
                 395 
               
               
                 1093 
                 17 
                 424 
               
               
                 1094 
                 10 
                 407 
               
               
                 1095 
                 12 
                 226 
               
               
                 1096 
                 10 
                 262 
               
               
                 1097 
                 9 
                 166 
               
               
                 1098 
                 23 
                 73 
               
               
                 1099 
                 35 
                 188 
               
               
                 1100 
                 4 
                 45 
               
               
                 1101 
                 3 
                 27 
               
               
                 1102 
                 8 
                 63 
               
               
                 1103 
                 5 
                 26 
               
               
                 1104 
                 3 
                 53 
               
               
                 1105 
                 5 
                 90 
               
               
                 1106 
                 5 
                 76 
               
               
                 1107 
                 3 
                 65 
               
               
                 1108 
                 4 
                 31 
               
               
                 1109 
                 5 
                 57 
               
               
                 1110 
                 26 
                 79 
               
               
                 1111 
                 13 
                 98 
               
               
                 1112 
                 76 
                 1000 
               
               
                 1113 
                 22 
                 444 
               
               
                 1114 
                 5 
                 408 
               
               
                 1115 
                 6 
                 176 
               
               
                 1116 
                 38 
                 1000 
               
               
                 1117 
                 29 
                 561 
               
               
                 1118 
                 28 
                 921 
               
               
                 1119 
                 11 
                 351 
               
               
                 1120 
                 6 
                 88 
               
               
                 1121 
                 2 
                 59 
               
               
                 1122 
                 2 
                 47 
               
               
                 1123 
                 2 
                 42 
               
               
                 1124 
                 4 
                 138 
               
               
                 1125 
                 4 
                 51 
               
               
                 1126 
                 5 
                 66 
               
               
                 1127 
                 13 
                 221 
               
               
                 1128 
                 9 
                 307 
               
               
                 1129 
                 5 
                 148 
               
               
                 1130 
                 10 
                 103 
               
               
                 1131 
                 3 
                 38 
               
               
                 1132 
                 8 
                 175 
               
               
                 1133 
                 4 
                 27 
               
               
                 1134 
                 2 
                 57 
               
               
                 1135 
                 2 
                 44 
               
               
                 1136 
                 4 
                 128 
               
               
                 1137 
                 5 
                 70 
               
               
                 1138 
                 4 
                 61 
               
               
                 1139 
                 13 
                 82 
               
               
                 1140 
                 22 
                 119 
               
               
                 1141 
                 2 
                 69 
               
               
                 1142 
                 2 
                 31 
               
               
                 1143 
                 7 
                 239 
               
               
                 1144 
                 11 
                 379 
               
               
                 1145 
                 5 
                 99 
               
               
                 1146 
                 2 
                 33 
               
               
                 1147 
                 2 
                 15 
               
               
                 1148 
                 2 
                 20 
               
               
                 1149 
                 4 
                 45 
               
               
                 1150 
                 2 
                 27 
               
               
                 1151 
                 2 
                 36 
               
               
                 1152 
                 3 
                 49 
               
               
                 1153 
                 2 
                 42 
               
               
                 1154 
                 2 
                 45 
               
               
                 1155 
                 1 
                 60 
               
               
                 1156 
                 1 
                 13 
               
               
                 1157 
                 3 
                 15 
               
               
                 1158 
                 2 
                 26 
               
               
                 1159 
                 50 
                 421 
               
               
                 1160 
                 71 
                 930 
               
               
                 1161 
                 14 
                 45 
               
               
                 1162 
                 16 
                 477 
               
               
                 1163 
                 19 
                 463 
               
               
                 1164 
                 13 
                 66 
               
               
                 1165 
                 9 
                 102 
               
               
                 1166 
                 5 
                 47 
               
               
                 1167 
                 5 
                 62 
               
               
                 1168 
                 4 
                 75 
               
               
                 1169 
                 234 
                 1000 
               
               
                 1170 
                 217 
                 1000 
               
               
                   
               
            
           
         
       
     
     The data in Table 4 and Table 5 shows that the compounds disclosed herein are effective inhibitors of cancer Osaka thyroid (Cot). In addition, the claimed compounds are not significant EGFR ligands. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 4 
               
               
                   
               
               
                   
                   
                   
                 EGFR 
               
               
                   
                   
                 IC 50 /EC 50   
                 (IC 50 ) 
               
               
                 Compound 
                 Compound Structure 
                 [nM] 
                 [nM] 
               
               
                   
               
             
            
               
                 Comparative Example 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                  4/310 
                  357 
               
               
                   
               
               
                 Comparative Example 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62/Na 
                 Na 
               
               
                   
               
               
                 919 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                  2/62 
                 2291 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                 TABLE 5 
               
               
                   
               
               
                   
                   
                   
                 EGFR 
               
               
                   
                   
                 IC 50 /EC 50   
                 (IC 50 ) 
               
               
                 Compound 
                 Compound Structure 
                 [nM] 
                 [nM] 
               
               
                   
               
             
            
               
                 Comparative Example 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   67/&gt;10000 
                 &gt;10000 
               
               
                   
               
               
                 Comparative Example 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 &gt;10000/Na   
                 &gt;10000 
               
               
                   
               
               
                 920 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 10/215 
                 &gt;10000